cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
An intensive virtual reality program improves balance and functional mobility of adolescents with cerebral palsy
Creators: name: Brien, Marie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Health Sciences, Recreation.

description: This study examined the effect of an intensive virtual reality (VR) intervention on balance and functional mobility in four adolescent males (mean age 16 years, range 13 years 9 months to 18 years 9 months) with cerebral palsy (CP) in a Gross Motor Classification System (GMFCS) level I. A single-subject multiple baseline experimental design (ABA) was used. Outcome measures were the Community Balance and Mobility Scale (CB&M), the Six-minute Walk Test (6MWT), the Timed Up and Down Stairs Test (TUDS) and the Gross Motor Function Measure (GMFM)-Dimension E. The participants were evaluated between three and six times in the baseline phase, five times in the intervention phase, and four times in the follow-up phase. The intervention consisted of an intensive 90-minute virtual reality-based balance training program for five consecutive days. Analysis consisted of visual and statistical analyses of graphed data as well as analyses of clinical significance. All adolescents demonstrated statistically significant improvements on the CB&M and the 6MWT during the intervention phase and these improvements were maintained the week following the intervention as well as at one month follow-up. Statistically significant improvements on TUDS scores were present in one adolescent at intervention and follow-up. One adolescent showed statistically significant improvements on the GMFM-dimension E and reached a ceiling effect on the GMFM-Dimension E at intervention and follow-up. For the CB&M, reliable changes in mean scores were recorded in three out of four adolescents in the intervention phase and in all adolescents in the follow-up phase. For the 6MWT, one adolescent reached the minimal detectable change (MDC) value in the intervention phase that demonstrates significance for the mean distance walked. Three adolescents reached the MDC value in the follow-phase. This study supports two major findings in adolescents with CP in GMFCS Level I. First, our data suggest that functional balance and mobility of these 13 to 18 year old adolescents with CP can improve with an intense, short duration VR intervention. Second, our data indicate that changes are maintained for at least one month following the VR training. For all participants, a causal relationship was established between the VR intervention and the significant improvements on the CB&M and the 6MWT. This relationship was maintained in the follow-up phase. The study provides evidence that balance and functional mobility are modifiable in ambulatory adolescents with CP in GMFCS Level I and that these adolescents have the potential to enhance their repertoire of complex movement strategies.
Genocide denial on the Internet: The cases of Armenia and Rwanda
Creators: name: Butera, Johny-Angel
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Sociology, Criminology and Penology.
subject: Mass Communications.

description: The regimes of truth within society, or those types of discourse accepted and made to function as true by truth-generating apparatuses, determine which events are classified as genocide and the types of evidence that are accepted as proof that a genocide has occurred. Genocide denial can be seen as an attempt to resist a regime of truth by putting forth an alternative analysis of a particular situation. Genocide deniers promote their discourse of denial as legitimate, scholarly efforts at historical revision with the intention of having another version of the truth exposed. Most research on genocide denial has focused primarily on the Holocaust, international debates to legislate genocide denial and the motivations and arguments used to deny genocide. This thesis qualitatively and thematically analyzes sixteen websites and twenty-eight documents to investigate the use of the Internet to produce and circulate discourses questioning the Armenian and Rwandan genocides. It argues that the Internet formulates a space and community in which genocide denial discourse is created, legitimized and disseminated. Then, through a vocabulary of motives framework, this thesis analyzes the logic of denial discourse to identify them as discursive strategies of truth production and to identify the ideological roots of denial. It is found that in Turkey's case, denial is rooted in a sense of collective victimization and nationalism and its presence on the Internet demonstrates the existence of a regime of truth denying the Armenian genocide. For Rwanda, denial is call for the recognition of victim suffering and for justice in revealing an alternative discourse that has been subjugated to the accepted history of the genocide.
Ly49 Receptors and MHC-I Interactions, and their Implications in Cancer Immunosurveillance
Creators: name: Tu, Megan Mai
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: subject: Cancer
subject: Immunology
subject: FOS: Clinical medicine

description: Natural killer cells are part of the innate immune response, and get their name ‘natural killer’ due to their unique ability to recognize and kill aberrant cells without prior sensitization. The Ly49 receptors on NK cells are involved in both their education process and mediating their ability to recognize aberrant cells. Virally-infected and tumor cells have been shown to exhibit decreased levels of MHC-I on their cell surface. As MHC-I is expressed on all nucleated cells, the Ly49 receptors on NK cells recognize this loss of MHC-I on the surface as a kill signal, leading to direct cytotoxicity through the release of perforin and granzymes. This recognition process by NK cells is termed “missing-self.” The interactions between MHC-I and Ly49 receptors are integral to NK cell function. The response of the NK cell to cells which it encounters is dependent on a balance of activating and inhibitory receptors. This signal in turn is dependent on the engagement and interactions of various ligands, such as MHC-I, by the activating and inhibitory Ly49s on the NK cells. In this compilation of my three main research projects, the interactions and binding capacity between the different MHC-I molecules and different members of the Ly49 receptor family are explored. In addition, the importance of the Ly49 receptors in NK cell-mediated cancer immunosurveillance is studied.
title: Síndrome de abalonamiento transitorio del ventrículo izquierdo: Nueva variante y aportaciones de la RM
Creators: name: Badillo Rodríguez-Portugal, Silvia
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Cardiac
subject: MR
subject: Education
subject: Oedema
subject: Acute
subject: Inflammation

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Losobjetivos de esta presentación son: -Identificar la presentación clínica de la miocardiopatía de estrés. -Conocer el fenómeno fisiopatológico primario,así como los principales desencadenantes de esta miocardiopatía. -Conocer las...
Deliverable D1.3_Data Management Plan (SOIL O-LIVE_HORIZON EUROPE ID 101091255)
Creators: name: Manzaneda Avila, Antonio Jose
Publisher: name: Zenodo
Year: 2025
Subjects: soil o-live
D1.3
DMP

description: D1.3: Elaboration of Data management plan for the project. (T.1.4)(T1.6) To ensure an effective contribution to the EUSO, the consortium will identify in the DMPs which knowledge and specific datasets might be of relevance to the EUSO and appoint a contact person to participate in discussions on data management with the JRC’s EUSO.
Supplementary document for Mapping the free-space propagation of light to inhomogeneous non-Hermitian media - 4580456.pdf
Creators: name: Makris, Konstantinos
name: Kresic, Ivor
name: Brandstötter, Andre
name: Rotter, Stefan
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized
Optical Physics not elsewhere classified

description: Supplemental document
La critique identitaire, la liberté d'expression, ou, La pensée juridique à l'ère de l'angoisse : un essai critique d'épistémologie de la pensée juridique.
Creators: name: Gaudreault-DesBiens, Jean-Francois.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Law.

description: Comme jamais auparavant, on assiste dans les societes nord-americaines a une juridicisation du phenomene identitaire. Dans cette foulee, plusieurs mouvements critiques d'origine americaine, regroupes dans cette these sous l'appellation de critique juridique identitaire, s'en prennent a la saisie juridique moderne des identites et a ses presupposes intellectuels, comme l'objectivisme ou le rationalisme, qui, disent-ils, ont permis d'occulter l'existence de plusieurs groupes historiquement desavantages ou les ont relegues a la marge de la societe. Des juristes issus de ces groupes se sont donc donne pour mission de transformer la saisie juridique des identite en insistant sur la necessite de faire une plus grande place aux subjectivites identitaires, individuelles et collectives. Leurs propositions n'ont pas manque de susciter de vifs debats dans la communaute juridique americaine, au point d'ebranler l'edifice de l'epistemologie juridique positiviste. Mais, trop souvent, les juristes qui participent a ces debats tombent dans le manicheisme ou fondent leur argumentation sur des presupposes essentialistes, qui bloquent les debats plutot que de les faire progresser. Aussi, abordant sous l'angle de l'epistemologie de la pensee juridique les discours qui, surtout aux Etats-Unis, s'affrontent dans le cadre de cette juridicisation de l'identitaire, cette these entend en premier lieu contribuer a la reflexion sur la problematique "droit et identite" en proposant des parametres theoriques en vue de favoriser une saisie juridique complexe des phenomenes identitaires. Les effets de cette saisie juridique deficiente de l'identite se font sentir jusque dans l'interpretation des droits constitutionnels fondamentaux, notamment au moment de concilier la liberte d'expression et l'egalite. Cette these s'interesse donc specifiquement aux idees avancees par les tenants de la critique juridique identitaire au sujet du rapport qui devrait etre etabli entre ces deux droits dans l'optique d'une meilleure apprehension de l'expression antiegalitaire. La problematique que pose la saisie juridique de cette forme d'expression s'avere particulierement interessante en ce qu'elle se situe a l'interface des preoccupations contemporaines concernant l'avenir du constitutionnalisme dans les societes multiculturelles, les processus de transformation du droit constitutionnel a l'ere postmoderne, et, enfin, la saisie juridique du phenomene identitaire. En ce sens, le second objectif de cette these est de determiner dans quelle mesure et a quelles conditions les proposition de reforme avancees par les tenants de la critique juridique identitaire s'averent cooptables dans le champ du droit. (Abstract shortened by UMI.)
Krytyczna analiza "Krytycznej analizy tezy o przydatności idei metafory konceptualnej w wykładni prawa" Roberta Piszki (Archiwum Filozofii Prawa i Filozofii Społecznej 2024/2)
Creators: name: Wojtczak, Sylwia
Publisher: name: Zenodo
Year: 2024
Subjects: subject: Law
subject: FOS: Law
subject: cognitive linguistics
subject: metaphor
subject: legal interpretation

description: Critical analysis of Robert Piszka's ‘Critical analysis of the thesis on the usefulness of the idea of conceptual metaphor in the interpretation of law’ (Archiwum Filozofii Prawa i Filozofii Społecznej 2024/2) - Polemic
Development of new QSAR models for water, sediment, and soil half-life
Creators: name: Arning, Jürgen
name: Lombardo, Anna
name: Manganaro, Alberto
Publisher: name: My University
Year: 2022
Subjects: Persistenz
QSAR-Modell
REACH-System

description: Checking the persistence of a chemical in the environment is extremely important. Regulations like REACH, the European one on chemicals, require the measurements or estimates of the half-life of the chemical in water, sediment, and soil. The use of non-testing methods, like quantitative structure-activity relationship (QSAR) models, is encouraged because it reduces costs and time. To our knowledge, there are very few freely available models for these properties and some are for specific chemical classes. Here, we present three new semi-quantitative models, one for each of the required environmental compartments (water, sediment, and soil). Using literature and REACH registration data, we developed three new counter-propagation artificial neural network models using the CPANNatNIC tool. We calculated the VEGA descriptors, and selected the relevant ones using an internal method in R based on the forward selection technique. The best model for each compartment was implemented in two open-source stand-alone tools, the VEGA platform, and the JANUS tool (https://www.vegahub.eu/). These models were also used by ECHA to build their PBT profiler available in the OECD QSAR toolbox (https://qsartoolbox.org/). Screening and prioritization are also our main target. The models perform well, with R2 always above 0.8 in training and validation. The only exception is the validation set of the soil compartment, with R2 0.68, that is above 0.8 only for compounds inside the applicability domain (automatically calculated by the system). The root mean square error (RMSE) is good, 0.34 or less in log units (again, for soil validation it is higher but it reaches 0.21 when considering only the compounds in the applicability domain). Compared with one of the most widely used tools, BIOWIN3, the proposed models give better results in terms of R2 and RMSE. For the classification, the performance is better for water and soil, and comparable or lower for sediment. © 2022 Elsevier
Water Stewardship: Attributes of Collaborative Partnerships between Mining Companies and Communities
Creators: name: Fraser, Jocelyn
name: Kunz, Nadja C.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: With many of the world’s largest mines operating in jurisdictions of water scarcity, competition for water has become a frequent source of tension between mining companies and other water users. Water stewardship is, therefore, becoming an important strategy for the mining sector to address stakeholder concerns and earn social acceptance. Collaborative partnerships between mining and other water users are a necessary component of advancing water stewardship, but the attributes needed to implement a successful water stewardship strategy are understudied. This paper addresses this gap by examining two exploratory case studies in Peru and Mongolia, where collaboration has been used as a strategy for promoting more sustainable outcomes in water-scarce regions. The findings suggest that while questions remain about who is best suited to lead collaborative partnerships, trust in the entity responsible for leading collaborative partnerships (especially in situations of high conflict) and a willingness to allow each partner to play to their strengths are critical attributes of success. We conclude that the outcome of collective action between mining companies and other water users offers the potential to deliver both business and social value, and to advance more sustainable water management.
title: Estudio por RM de la degeneración del manguito rotador después de una fractura de húmero proximal tratada de forma conservadora
Creators: name: Alcantara da Silva, Rodrigo
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Musculoskeletal bone
subject: Musculoskeletal soft tissue
subject: MR

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
Analizar los cambios degenerativos presentes en el manguito rotador después de una fractura proximal de húmero tratada de forma conservadora. Valorar mediante cuestionarios validados y análisis estadístico la forma como dichos cambios...
Supplementary document for Mapping the free-space propagation of light to inhomogeneous non-Hermitian media - 4580456.pdf
Creators: name: Makris, Konstantinos
name: Kresic, Ivor
name: Brandstötter, Andre
name: Rotter, Stefan
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Uncategorized
Optical Physics not elsewhere classified

description: Supplemental document
title: Estudio de la malformación adenomatoidea pulmonar congénita mediante RM fetal.
Creators: name: Couto Rodriguez, Iria
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Obstetrics (Pregnancy / birth / postnatal period)
subject: Thorax
subject: Paediatric
subject: MR
subject: Intrauterine diagnosis
subject: Foetus

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
El conocimiento del comportamiento de la MAPc en resonancia magnética (RM) fetal es importante a la hora de enfrentarnos a una sospecha ecográfica de esta entidad,
ya que su diagnóstico implica un cambio en el manejo tanto de la paciente...
Galaxy and Mass Assembly (GAMA): A "no Smoking" Zone for Giant Elliptical Galaxies?
Creators: name: Khosroshahi, Habib G.
name: Raouf, Mojtaba
name: Miraghaei, Halime
name: Brough, Sarah
name: Croton, Darren
name: Driver, Simon
name: Graham, Alister
name: Baldry, Ivan
name: Brown, Michael
name: Prescott, Matt
name: Wang, Lingyu
Publisher: name: Swinburne
Year: 2024

description: We study the radio emission of the most massive galaxies in a sample of dynamically relaxed and unrelaxed galaxy groups from the Galaxy and Mass Assembly survey. The dynamical state of the group is defined by the stellar dominance of the brightest group galaxy (BGG), e.g., the luminosity gap between the two most luminous members, and the offset between the position of the BGG and the luminosity centroid of the group. We find that the radio luminosity of the largest galaxy in the group strongly depends on its environment, such that the BGGs in dynamically young (evolving) groups are an order of magnitude more luminous in the radio than those with a similar stellar mass but residing in dynamically old (relaxed) groups. This observation has been successfully reproduced by a newly developed semi-analytic model that allows us to explore the various causes of these findings. We find that the fraction of radio-loud BGGs in the observed dynamically young groups is ∼2 times that of the dynamically old groups. We discuss the implications of this observational constraint on the central galaxy properties in the context of galaxy mergers and the super massive black hole accretion rate.
Signaling pathways linking behavior to neurogenesis in healthy brain and disease
Creators: name: Klempin, Friederike
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: serotonin
subject: neurogenesis
subject: physical exercise
subject: Pax6
subject: BDNF
subject: ACE2
subject: Bradykinin
subject: ECT
subject: 600 Technology, Medicine, Applied sciences::610 Medical sciences; Medicine::610 Medical sciences; Medicine

description: Self-repair of the adult brain is limited – most diseases lack effective therapy. In order to better understand how a regenerative response can be achieved, studying mechanisms shaping the neurogenic niche, from environmental factors to intrinsic signaling, is of significance. My work highlights the enormous plasticity of the CNS and the crucial role of serotonin in affecting the behavior of neural stem/progenitor cells. It allows important insights into antidepressant strategies that involve physical activity, adult neurogenesis, BDNF, and signals of the vascular niche. Future research will have to elucidate the systemic cues and targets that regulate neuroplasticity and how they become deregulated in disease. It remains to be seen how they will contribute to the development of novel therapies and biomarkers for cognitive disorders.
Australian Criminal Law Regulators, Disruptors and the Need for Cyber-Systemics
Creators: name: Walker-Munro, Brendan
Publisher: name: Swinburne
Year: 2024

description: This thesis presents a consolidated approach to regulation that bridges the principles of cybernetics and systemic design. This approach is benchmarked against studies around organised crime, as well as two specific case studies on existing regulatory practice in Australia (encrypted messaging and financial crime). This thesis also presents an opportunity to engage in design discussions around how regulation should be approached in the new century. My approach ought to encourage debate, critique and discussion in an area of law and practice that is sorely needed as we evolve as a people and as a society.
ENHANCING AVIAN HEALTH: ASSESSING THE EFFECTS OF BORIC ACID SUPPLEMENTATION ON SERUM ALBUMIN IN QUAIL DIETS
Creators: name: Maria, Russo
name: Antonio, Pereira
Publisher: name: continental journal
Year: 2024
Subjects: Boric acid, medical applications, antioxidant effects, physiological processes, oxidative stress

description: Boric acid, a versatile inorganic acid known for its applications in pest control, fungistatic properties, ceramics, and cosmetics, has recently garnered attention for its potential medical uses. Studies have revealed its involvement in various physiological processes, including immune responses, endocrine regulation, mineral metabolism, and lipid homeostasis. Additionally, boric acid exhibits antioxidant properties, although the underlying mechanisms remain partially elucidated. Research suggests that boric acid treatment can mitigate oxidative metabolism inhibition resulting from mitochondrial degeneration. However, excessive boric acid usage may induce oxidative stress in the reproductive system. This abstract provides an overview of boric acid's multifaceted roles and underscores the need for further exploration of its medical applications and antioxidant mechanisms.
title: Women's reasons for participation in a clinical trial for menstrual pain
title: a qualitative study
titleType: Subtitle
Creators: name: Bloedt, Susanne
name: Witt, Claudia M.
name: Holmberg, Christine
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Objectives: The aim of the study was to explore women's motivations for participating in a clinical trial and to evaluate how financial compensation impacts women's explanations for participation. Design, setting and participants: Semistructured interviews were conducted face to face or by telephone with 25 of 220 women who participated in a pragmatic randomised trial for app-administered self-care acupressure for dysmenorrhoea (AKUD). Of these 25 women, 10 had entered AKUD knowing they would receive a financial compensation of €30. A purposive sampling strategy was used. Results: Women had a long history of seeking help and were unsatisfied with the options available, namely painkillers and oral contraceptives. While interviewees were open to painkillers, they were uneasy about taking them on a monthly basis. The AKUD trial offered the possibility to find an alternative solution. A second reason for participation was the desire to add a new treatment to routine medical care, for which the interviewees considered randomised trials a prerequisite. The financial incentive was a subsidiary motivation in the interviewees' narratives. Conclusions: Our results contribute to the ongoing discussion of the impact of financial compensation on research participants' assessment of risk. The interviewed women considered all research participants able to make their own choices regarding trial participation, even in the face of financial compensation or payment of study participants. Furthermore, the importance of clinical trials providing new treatments that could change medical practice might be an overlooked reason for trial participation and could be used in future recruitment strategies.
Supplementary document for Single-molecule orientation localization microscopy for resolving structural heterogeneities within amyloid fibrils - 4582708.pdf
Creators: name: Ding, Tianben
name: Wu, Tingting
name: Mazidi, Hesam
name: Zhang, Oumeng
name: Lew, Matthew
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Biophysics
Nanoscale Characterisation

description: Supplement 1
Heavy Space Industries: A Vision for Sustainable Industrialization Beyond Earth
Creators: name: Billions, Ava
name: Knight, Chris
Publisher: name: Zenodo
Year: 2024

description: Abstract:

The 21st century is a time of extraordinary technological progress, yet humanity faces the urgent challenge of a warming planet and dwindling resources. "Heavy Space Industries" emerges as a bold solution, proposing the relocation of energy-intensive and polluting industries off-Earth, with the potential to reduce global CO2 emissions by up to 46%. It explores the design and capabilities of the Heavy Space Industries LEO (Low Earth Orbit) Ships, forming a network of orbital "hubs" along a proposed Earth-Mars "Space Highway." By leveraging existing technologies and embracing the potential of artificial intelligence (AI), robotics, and human collaboration, this concept envisions a future where space becomes a frontier for sustainable industrialization, resource utilization, and human expansion.
Grenzüberscheitende Abfallverbringung und die neuen Kunststoffeinträge
Creators: name: Gerke, Gilian
name: Janousch, Erik
name: Tegtmeier, Lars
Publisher: name: Umweltbundesamt
Year: 2023
Subjects: subject: Abfallexport
subject: Basler Übereinkommen
subject: Grenzüberschreitende Abfallverbringung
subject: Kunststoffabfälle
subject: Vollzug und Kontrollen
subject: Abfallverbringungsverordnung
subject: Abfall | Ressourcen

description: Vor dem Hintergrund der neuen Einträge für Kunststoffeinträge die seit dem 1.1.2021 in EU-Recht umgesetzt worden sind, richtet sich diese Umsetzungshilfe an alle Unternehmen bzw. Einrichtungen, die sich im Umgang mit Kunststoffabfällen grenzüberschreitend befassen. Dazu gehören insbesondere Abfallerzeuger, Abfallbehandler wie z.B. Sortierer und Verwerter, Transporteure sowie Behörden im Vollzug und bei der Kontrolle. Damit dient sie als Hilfestellung zur richtigen Einordnung der neuen Kunststoffeinträge nach der Abfallverbringungsverordnung und dem Umgang in der Praxis mit den in den Anlaufstellen-Leitlinien Nr. 12 näher erläuterten Begriffsregelungen. Quelle: www.umweltbundesamt.de
description: Vor dem Hintergrund der neuen Einträge für Kunststoffeinträge die seit dem 1.1.2021 in EU-Recht umgesetzt worden sind, richtet sich diese Umsetzungshilfe an alle Unternehmen bzw. Einrichtungen, die sich im Umgang mit Kunststoffabfällen grenzüberschreitend befassen. Dazu gehören insbesondere Abfallerzeuger, Abfallbehandler wie z.B. Sortierer und Verwerter, Transporteure sowie Behörden im Vollzug und bei der Kontrolle. Damit dient sie als Hilfestellung zur richtigen Einordnung der neuen Kunststoffeinträge nach der Abfallverbringungsverordnung und dem Umgang in der Praxis mit den in den Anlaufstellen-Leitlinien Nr. 12 näher erläuterten Begriffsregelungen.
E-RIHS IP D2.5 Guidelines for the E-RIHS Central Hub Management Practices
Creators: name: STRIOVA, JANA
name: Benassi, Laura
name: Manconi, Silvia
name: Chaban, Antonina
name: Buti, David
name: Doherty, Brenda
name: Petitcol, Rémi
name: Cano, Emilio
name: Ramírez Barat, Blanca
name: Molina, Teresa
name: Virgili, Vania
name: Van't Hoff, Jan
name: Mims, Andrews
name: Grau-Bove, Josep
name: Strlič, Matija
Publisher: name: Zenodo
Year: 2024
Subjects: Helpdesk
User
Central Hub
ERIC
Management

description: The document titled E-RIHS IP D2.5 Guidelines for the E-RIHS Central Hub Management Practices outlines the management practices for the E-RIHS ERIC Central Hub, located in Florence, Italy. The E-RIHS ERIC Central Hub hosts the legal seat and serves as the headquarters of the ERIC. It is regulated by the Article 19 of the E-RIHS ERIC Statutes and is managed by the Director General. It plays a crucial role in supporting the coordinated operations of E-RIHS ERIC by providing assistance to ensure its implementation. Its staff assists the Director General in the scientific, administrative, and financial coordination of the ERIC and the other governance bodies of E-RIHS ERIC, such as the General Assembly, the Committee of National Nodes, and the Scientific and Ethics Advisory Board. The guidelines described in this document are tailored to ensure efficient and coordinated operation of the distributed research infrastructure, in accordance with the legal requirements applicable to the operation of an ERIC. They cover some of the Central Hub’s key operational practices, including service provision, training, communication, event organization, KPI monitoring, and Risk Management. The document also includes comparative analyses to benchmark the E-RIHS Central Hub’s practices against other research infrastructures, offering elements for reflection and further adaptation. This deliverable is conceived as a living document, to be regularly updated and revised.
Supplementary document for Single-molecule orientation localization microscopy for resolving structural heterogeneities within amyloid fibrils - 4582708.pdf
Creators: name: Ding, Tianben
name: Wu, Tingting
name: Mazidi, Hesam
name: Zhang, Oumeng
name: Lew, Matthew
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Biophysics
Nanoscale Characterisation

description: Supplement 1
Development and psychometric evaluation of an instrument assessing barriers to growth hormone treatment (BAR-GHT)
Creators: name: De Zwaan, Martina
name: Fischer-Jacobs, Josefine
name: Wabitsch, Martin
name: Reinehr, Thomas
name: Meckes-Ferber, Stefanie
name: Crosby, Ross D.
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: growth hormone therapy
subject: barriers
subject: patient reported outcome measure
subject: adherence
subject: DDC 610 / Medicine & health
subject: Human growth hormone; Therapeutic use
subject: Treatment outcome
subject: Factor analysis, Statistical
subject: Somatotropin
subject: Wachstum
subject: Therapietreue
subject: Faktorenanalyse

description: Purpose: This paper presents development and validation of a new patient reported outcome measure (PRO), the Barriers to Growth Hormone Therapy (BAR-GHT) in a patient (child/adolescent) and a parent version. The BAR-GHT was developed to measure problems and potential barriers to GHT. Methods: The development and validation of the BAR-GHT was conducted according to the Food and Drug Administration (FDA) Guidance on the development of PROs. Concept elicitation included a literature review and open-ended interviews with young patients, parents, and clinical experts. Qualitative data were analyzed based on grounded theory principles and draft items were rated in terms of their importance and clarity. The instruments underwent psychometric validation in a German clinic-based patient population of children and adolescents who inject themselves and in a parent sample who inject their child. The statistical analysis plan included exploratory factor analysis, reliability, and validity. Results: 29 patients, 22 parents, and 4 clinical experts participated in the concept elicitation, 156 children and adolescents aged 8–18 years and 146 parents completed the validation study. Exploratory factor analysis resulted in six domains: Fear, Public Embarrassment, Annoyance, Daily Routine, Supplies, and Travel. Internal consistencies and test-retest reliabilities of the total score of both the patient version and the parent version were >0.8. Convergent and discriminant validity was demonstrated. Conclusions: The final 19-item BAR-GHT for patients aged 8–18 years and the 16-item version for parents can be considered reliable and valid PROs of barriers to GHT. Clinical Trial Registration: www.ClinicalTrials.gov, identifier: NCT03672617. Universal Trial Number (UTN) of the International Clinical Trials Registry Platform (ICTRP, www.who.int): U1111-1210-1036.
Heterogeneity of lymphokine-activated killer cells: Role of interleukin-2 and interleukin-4.
Creators: name: Alvi, Azra Johanna.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Biology, Cell.

description: Our main objective was to determine if the Lymphokine Activated Killer cells (LAK) activity is restricted to Natural Killer (NK) cells or if it is also detectable in T cell subsets, especially in CD3+ T cells that are also negative for CD4 and CD8 cell surface markers. We were able to obtain highly purified subsets of NK cells, helper/inducer (CD3+4+8$-$), suppressor/cytotoxic (CD3+4$-$8+) and double negative (CD3+4$-$8$-$) T cells. The double negative T cells are now known to be a subset of $\gamma\delta$-T cells. Highly purified subsets were obtained using antibody (sheep anti-mouse IgG) coated magnetic particles and monoclonal antibodies. The purified subsets were tested for LAK activity against a standard target cell (K562), a NK resistant/LAK sensitive target cell (HTB 38), and a NK/LAK resistant target cell. We found NK cells develop LAK activity after IL-2 stimulation and that two T cell subsets (cytotoxic/suppressor and double negative) consistently showed LAK activity (3 experiments). The helper/inducer subset showed LAK activity in 2 of 3 experiments. Interleukin 4 had an inhibitory effect on the proliferative activity of IL-2 stimulated T cells and was not used in the LAK experiments. In conclusion we have found that the LAK function is a property of an heterogeneous group of lymphocyte subsets that includes NK cells and T cell subsets. (Abstract shortened by UMI.)
Oxyfuel – Verbrennung (Factsheet)
Creators: name: NEFI New Energy for Industry
Publisher: name: NEFI
Year: 2024
Subjects: NEFI
Innovationsnetzwerk
Energie
Industrie
New Energy for Industry
Klima- und Energiefonds
Vorzeigeregion
Verbrennung
Hochtemperaturprozesse
Brennstoffeinsparungen
Kosteneinsparungen
Betrieb

description: Die Oxyfuel-Technologie verwendet reinen Sauerstoff anstelle von Luft für die Verbrennung, was zu höheren Flammentemperaturen führt. Dies wiederum führt zu einer effizienteren Verbrennung mit geringerem Brennstoffverbrauch und reduzierten CO₂-Emissionen. Zusätzlich unterstützt dieser Prozess die Abscheidung und Nutzung von CO₂.

Die Anwendung von Oxyfuel ist grundsätzlich in allen Verbrennungsprozessen möglich. Besonders vielversprechend sieht NEFI das Potenzial in der Stahlindustrie, in Verbindung mit Elektrolichtbogenöfen, sowie in der Zementbranche.
Efficient Privacy Preservation in Smart Grid
Creators: name: Ul Hassan, Muneeb
Publisher: name: Swinburne
Year: 2024

description: Due to bidirectional flow of energy and information, modern energy systems generate a vast amount of data. This data indeed provides various benefits, but it also raises a large number of privacy concerns for the participating users. For example, real-time energy usage information of a home can lead to identification of daily routine of the residents. Therefore, in this thesis, I work on overcoming these privacy issues in order to provide smart grid users a safe and secure environment in which they will be able to utilize the benefits of modern smart grid without the risk of losing their privacy.
Probe influence on integrated antenna measurements at frequencies above 100 GHz
Creators: name: Böhm, Linus
name: Hitzler, Martin
name: Roos, Fabian
name: Waldschmidt, Christian
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: Antenna measurements
subject: Integrated antenna
subject: Wafer probe
subject: DDC 620 / Engineering & allied operations
subject: Antennas (Electronics)
subject: Probes (Electronic instruments)
subject: Antennenmesstechnik
subject: Antenne
subject: Wafer

description: When measuring integrated antennas the signal has to be fed to the antennas with wafer probes. Wafer probes are commonly used to contact integrated circuits for on-chip measurements. As integrated radar and communication chips with radiating elements are a fairly recent development, the wafer probes were not optimized for size and reflective properties (characteristics which are important for antenna measurements), but rather for their return loss, insertion loss, and mechanical stability. This resulted in metal probes that are relatively large compared to the wavelength. In this paper, two probes are compared with regard to their performance in integrated antenna measurements. The first probe is a standard commercially available probe. The second one is a modified probe with an extended coaxial probe tip to increase the distance between probe and antenna, which decreases the distortion and reflection caused by the probe significantly.
Corporate sustainability of Japanese multinational enterprises in ASEAN
Creators: name: Ike, Masayoshi
Publisher: name: Swinburne
Year: 2024

description: This thesis investigates how Japanese manufacturing multinational enterprises operating in the Association of Southeast Asian Nations, meet the challenges of sustainability. The research was carried out through semi-structured interviews with 58 representatives from 16 Japanese multinational enterprises operating in the Philippines, Indonesia, Vietnam, and Thailand. This thesis provides unique insights into how management understand sustainability, and the prioritisation processes for engaging with sustainability. Alongside these insights, the thesis presents a practical assessment tool for assessing the sustainability performance of multinational enterprises against the Sustainable Development Goals, and how sustainability reporting can be better targeted towards achieving local legitimacy.
The effect of renal denervation on plasma adipokine profile in patients with treatment resistant hypertension
Creators: name: Eikelis, Nina
name: Hering, Dagmara
name: Marusic, Petra
name: Duval, Jacqueline
name: Hammond, Louise J.
name: Walton, Antony S.
name: Lambert, Elisabeth
name: Esler, Murray D.
name: Lambert, Gavin
name: Schlaich, Markus P.
Publisher: name: Swinburne
Year: 2024

description: Background: We previously demonstrated the effectiveness of renal denervation (RDN) to lower blood pressure (BP) at least partially via the reduction of sympathetic stimulation to the kidney. A number of adipocyte-derived factors are implicated in BP control in obesity. Aim: The aim of this study was to examine whether RDN may have salutary effects on the adipokine profile in patients with resistant hypertension (RH). Methods: Fifty seven patients with RH undergoing RDN program have been included in this study (65% males, age 60.8 ± 1.5 years, BMI 32.6 ± 0.7 kg/m2, mean ± SEM). Throughout the study, the patients were on an average of 4.5 ± 2.7 antihypertensive drugs. Automated seated office BP measurements and plasma concentrations of leptin, insulin, non-esterified fatty acids (NEFA), adiponectin and resistin were assessed at baseline and the 3 months after RDN. Results: There was a significant reduction in mean office systolic (168.75 ± 2.57 vs. 155.23 ± 3.17 mmHg, p < 0.001) and diastolic (90.68 ± 2.31 vs. 83.74 ± 2.36 mmHg, p < 0.001) BP 3 months after RDN. Body weight, plasma leptin and resistin levels and heart rate remained unchanged. Fasting insulin concentration significantly increased 3 months after the procedure (20.05 ± 1.46 vs. 29.70 ± 2.51 uU/ml, p = 0.002). There was a significant drop in circulating NEFA at follow up (1.01 ± 0.07 vs. 0.47 ± 0.04 mEq/l, p < 0.001). Adiponectin concentration was significantly higher after RDN (5,654 ± 800 vs. 6,644 ± 967 ng/ml, p = 0.024). Conclusions: This is the first study to demonstrate that RDN is associated with potentially beneficial effects on aspects of the adipokine profile. Increased adiponectin and reduced NEFA production may contribute to BP reduction via an effect on metabolic pathways.
title: Leitfaden Tieffrequente Geräusche im Wohnumfeld
title: Tieffrequente Geräusche im Wohnumfeld
titleType: AlternativeTitle
Creators: name: Möhler, Ulrich
name: Eulitz, Christian
Publisher: name: My University
Year: 2017
Subjects: subject: Tieffrequentes Geräusch
subject: Wohnumfeld
subject: Lärmbelästigung
subject: Brummton
subject: Belastungen im Wohnumfeld
subject: Lärm

description: Die Beeinträchtigungen durch tieffrequente Geräusche oder sogenannte „Brummton“-Phänomene im Wohnumfeld haben in den letzten Jahren deutlich zugenommen. Genaue Ursachen für das erhöhte Belästigungsempfinden sind nicht bekannt. Sicher ist jedoch, dass sich die akustische Landschaft des Wohnumfeldes wahrnehmbar verändert. Einerseits nehmen die Siedlungsdichte und der Verkehr zu, Wohngebäude werden schalldichter gebaut und technische Geräte – vom Heimnetzwerk über ⁠Klima⁠- und Lüftungsanlagen bis hin zum Staubsaugroboter – sollen den Komfort verbessern. Die Entwicklung dieser höheren Wohnstandards führt allerdings auch dazu, dass tieffrequente Geräusche stärker als bisher im Wohnumfeld auftreten. Auf der anderen Seite hat ebenso die Sensibilität der Bevölkerung gegenüber Umwelteinflüssen, speziell der Lärmbelastung, in den letzten Jahren zugenommen.
Comparison of logistic regression with machine learning methods for the prediction of fetal growth abnormalities: a retrospective cohort study
Creators: name: Kuhle, Stefan
name: Maguire, Bryan
name: Zhang, Hongqun
name: Hamilton, David
name: Allen, Alexander C.
name: Joseph, K. S.
name: Allen, Victoria M.
Publisher: name: BioMed Central
Year: 2018

description: Background: While there is increasing interest in identifying pregnancies at risk for adverse outcome, existing prediction models have not adequately assessed population-based risks, and have been based on conventional regression methods. The objective of the current study was to identify predictors of fetal growth abnormalities using logistic regression and machine learning methods, and compare diagnostic properties in a population-based sample of infants. Methods: Data for 30,705 singleton infants born between 2009 and 2014 to mothers resident in Nova Scotia, Canada was obtained from the Nova Scotia Atlee Perinatal Database. Primary outcomes were small (SGA) and large for gestational age (LGA). Maternal characteristics pre-pregnancy and at 26 weeks were studied as predictors. Logistic regression and select machine learning methods were used to build the models, stratified by parity. Area under the curve was used to compare the models; relative importance of predictors was compared qualitatively. Results: 7.9% and 13.5% of infants were SGA and LGA, respectively; 48.6% of births were to primiparous women and 51.4% were to multiparous women. Prediction of SGA and LGA was poor to fair (area under the curve 60–75%) and improved with increasing parity and pregnancy information. Smoking, previous low birthweight infant, and gestational weight gain were important predictors for SGA; pre-pregnancy body mass index, gestational weight gain, and previous macrosomic infant were the strongest predictors for LGA. Conclusions: The machine learning methods used in this study did not offer any advantage over logistic regression in the prediction of fetal growth abnormalities. Prediction accuracy for SGA and LGA based on maternal information is poor for primiparous women and fair for multiparous women.
title: Patient motives behind low-acuity visits to the emergency department in Germany
title: a qualitative study comparing urban and rural sites
titleType: Subtitle
Creators: name: Schmiedhofer, Martina
name: Moeckel, Martin
name: Slagman, Anna
name: Frick, Johann
name: Ruhla, Stephan
name: Searle, Julia
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Objectives: The increasing number of low-acuity visits to emergency departments (ED) is an important issue in Germany, despite the fact that all costs of inpatient and outpatient treatment are covered by mandatory health insurance. We aimed to explore the motives of patients categorised with low- acuity conditions for visiting an ED. Methods: We conducted a qualitative study in two urban and one rural ED. We recruited a purposive sample of adults, who were assigned to the lowest two categories in the Manchester triage system. One-to-one interviews took place in the ED during patients' waiting time for treatment. Interview transcripts were analysed using the qualitative data management software MAXQDA. A qualitative content analysis approach was taken to identify motives and to compare the rural with the urban sites. Results: A total of 86 patients were asked to participate; of these, n=15 declined participation and n=7 were excluded because they were admitted as inpatients, leaving a final sample of 40 female and 24 male patients. We identified three pathways leading to an ED visit: (1) without primary care contact, (2) after unsuccessful attempts to see a resident specialist or general practitioner (GP) and (3) recommendation to visit the ED by an outpatient provider. The two essential motives were (1) convenience and (2) health anxiety, triggered by time constraints and focused usage of multidisciplinary medical care in a highly equipped setting. All participants from the rural region were connected to a GP, whom they saw more or less regularly, while more interviewees from the urban site did not have a permanent GP. Still, motives to visit the ED were in general the same. Conclusions: We conclude that the ED plays a pivotal role in ambulatory acute care which needs to be recognised for adequate resource allocation. Trial registration number: DRK S00006053
In Vitro Comparison of Raypex 6 and Endopilot Using a Novel, Computer-Aided Measurement System, for Determining the Working Length
Creators: name: Christofzik, David
name: Schwendicke, Falk
name: Flörke, Christian
name: Härtl, Alexander
name: Dörfer, Christof
name: Größner-Schreiber, Birte
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Introduction Experimental evaluation of endometric devices usually relies on visual, subjective detection of the apical constriction to determine the accuracy of measurements. The aim of the present study was to analyze the accuracy of measurements of Raypex 6 and EndoPilot using a novel, objective image-analysis system. Methods Onehundred and twenty teeth were randomized and allocated to three groups: After coronal flaring, either Raypex 6 or EndoPilot were used to determine the endodontic working length during instrumentation using manual files (RPM and EPM group respectively). In addition, EndoPilot was used for continuous, automatic measurement during rotating instrumentation (EPA group). If the working length had been reached according to endometric results, the files were fixed in place. Tooth and file were then embedded and prepared for analysis. Subsequently, the distance between the tip of the file and the apical constriction (DAC) or the apical foramen (DAF) was calculated using trigonometric analysis and the position of the file relative to AC and AF was analyzed. Results Both inter- and intra-examiner-reliability of the trigonometric analysis were nearly perfect (ICC = 0.999, p<0.001). DAC was not significantly different between groups (p>0.05, t-test). DAF was significantly decreased when EPA had been used compared to EPM (p<0.05, Exact-test). EPA resulted in files being positioned beyond AF significantly more often than the other two methods (p<0.01). Conclusions All methods allowed reliable detection of AC. However, EPA significantly increased the risk of overpreparation. Objective, digital assessment based on image analysis was suitable to compare the accuracy of different endometric devices.