cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
sj-pdf-1-lup-10.1177_09612033211033979 - Supplemental material for Increased burden of rare variants in genes of the endosomal Toll-like receptor pathway in patients with systemic lupus erythematosus
Creators: name: Lea-Henry, Tom N
name: Chuah, Aaron
name: Stanley, Maurice
name: Athanasopoulos, Vicki
name: Starkey, Malcolm R
name: Christiadi, Daniel
name: Kitching, A Richard
name: Cook, Matthew C
name: Andrews, Thomas D
name: Vinuesa, Carola G
name: Walters, Giles D
name: Jiang, Simon H
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111702 Aged Health Care
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-1-lup-10.1177_09612033211033979 for Increased burden of rare variants in genes of the endosomal Toll-like receptor pathway in patients with systemic lupus erythematosus by Tom N Lea-Henry, Aaron Chuah, Maurice Stanley, Vicki Athanasopoulos, Malcolm R Starkey, Daniel Christiadi, A Richard Kitching, Matthew C Cook, Thomas D Andrews, Carola G Vinuesa, Giles D Walters and Simon H Jiang in Lupus
The safety analysis of lurasidone based on the real-world data of FAERS database
Creators: name: Luo, Ziyi
name: Zhang, Mengting
name: Liang, Weijian
name: Hu, Mianda
name: Jiang, Yunze
name: Lei, Xi
name: Wang, Zhenjie
name: Zhu, Jinfeng
name: Du, Yikuan
name: Liu, Yi
name: Yang, Chun
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Mental Health

description: To assess lurasidone’s real-world safety via retrospective analysis of post-marketing adverse reactions. Signal mining was carried out by retrieving the adverse events (AEs) associated with lurasidone from the FDA Adverse Event Reporting System (FAERS) database spanning from the first quarter of 2011 to the fourth quarter of 2023. Disproportionality analyses including Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), and empirical Bayesian geometric mean (EBGM) were used to assess the presence of significant associations between lurasidone and AEs. From the 10,176,406 reports collected in the FAERS database, a total of 12,451 reports of lurasidone-related AEs were identified, which focused on Psychiatric disorders (n = 8950), notably, akathisia and parkinsonian rest tremor are strongly associated with lurasidone; Breast engorgement, galactorrhea, breast discharge, and umbilical cord around neck and new ocular AEs including oculogyric crisis, excessive eye blinking, and blepharospasm, have not been mentioned in the specification. The most common and most severe PT reported was off-label use, followed by suicidal ideation. This study reveals known and unexpected AEs about lurasidone, related to the eye, lactating women and life-threatening threats, and underscores the need for ongoing post-marketing surveillance of lurasidone.
sj-pdf-1-inq-10.1177_00469580211030217 – Supplemental material for Designing a Pragmatic Intervention to Help Improve the Bladder Cancer Patient Experience
Creators: name: Bessa, Agustina
name: Bosco, Cecilia
name: Cahill, Fidelma
name: Russell, Beth
name: Fox, Louis
name: Moss, Charlotte
name: Wylie, Harriet
name: Haire, Anna
name: Green, Saran
name: Enting, Deborah
name: Khan, Shamim
name: Nair, Rajesh
name: Thurairaja, Ramesh
name: Chatterton, Kathryn
name: Amery, Suzanne
name: Peat, Nicola
name: Smith, Sue
name: Spear, Stuart
name: Bryan, Richard T
name: Frodsham, Leila
name: Burke, Danny
name: Rigby, Jeannie
name: Makaroff, Lydia
name: Kelly, Phil
name: Costin, Melanie
name: Häggström, Christel
name: Van Hemelrijck, Mieke
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-1-inq-10.1177_00469580211030217 for Designing a Pragmatic Intervention to Help Improve the Bladder Cancer Patient Experience by Agustina Bessa, Cecilia Bosco, Fidelma Cahill, Beth Russell, Louis Fox, Charlotte Moss, Harriet Wylie, Anna Haire, Saran Green, Deborah Enting, Shamim Khan, Rajesh Nair, Ramesh Thurairaja, Kathryn Chatterton, Suzanne Amery, Nicola Peat, Sue Smith, Stuart Spear, Richard T Bryan, Leila Frodsham, Danny Burke, Jeannie Rigby, Lydia Makaroff, Phil Kelly, Melanie Costin, Christel Häggström and Mieke Van Hemelrijck in INQUIRY: The Journal of Health Care Organization, Provision, and Financing
INFLUENCE OF TEAM FORMATION ON TEAM MEMBER PERCEPTION OF SATISFACTION AND PARTICIPATION
Creators: name: Claypool, Mallory
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Other engineering not elsewhere classified

description: Background: Purdue Polytechnic’s Tech12000, Design Thinking in Technology, course incorporates many instances of team work. Over the last 8 years, there have been varied methods of how to create the teams for the projects.
Purpose: This study compares two methods of team formation, software generated and instructor/student-selected, to determine which, if any, method generates increased perception of team member satisfaction and increased team member contribution.
Methodology: The subjects for this study were students enrolled in a design course at a Purdue Polytechnic, divided into a comparison group with instructor/student-selected teams, and a treatment group with software-generated teams. These students were predominately first year students enrolled in their first semester of college.
Findings/conclusions: The researcher discovered that the computer software-generated teams produced teams that had slightly larger mean scores on satisfaction and contribution versus the instructor/student-selected teams, although not at a statistically significant level.
Implications: The findings of this study provide another tool for educators, with possible implications for industry, to generate teams in the classroom.
Additional file 2 of Molecular and clinicopathologic characteristics of CNS embryonal tumors with BRD4::LEUTX fusion
Creators: name: Andreiuolo, Felipe
name: Ferrone, Christina K.
name: Rajan, Sharika
name: Perry, Arie
name: Guney, Ekin
name: Cham, Elaine
name: Giannini, Caterina
name: Toland, Angus
name: Willard, Nicholas
name: de Souza, Andrea Silveira
name: Dazelle, Karen
name: Chung, Hye-Jung
name: Singh, Omkar
name: Conway, Kyle
name: Coley, Nicholas
name: Dampier, Christopher
name: Abdullaev, Zied
name: Pratt, Drew
name: Cimino, Patrick J.
name: Quezado, Martha
name: Aldape, Kenneth
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Additional file 2: Fig. S1. CNV profiles. A. Case #1; unremarkable. B. Case #2; alterations include gain of 1q21.1q44, loss of 14q23.3q32.33 (including DICER1 and AKT1), and gain of chromosome 19 with a focal loss of 19q13.33q13.43 (including PPP2R1A, CACNG6, C19MC and TTYH1). C. Case #3; unremarkable. D. Case #4; unremarkable.
sj-docx-1-gpi-10.1177_13684302211015303 – Supplemental material for Preserving prosociality in the face of inequality: A role for multiple group memberships and superordinate group identification
Creators: name: Dare, Michael
name: Jetten, Jolanda
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, sj-docx-1-gpi-10.1177_13684302211015303 for Preserving prosociality in the face of inequality: A role for multiple group memberships and superordinate group identification by Michael Dare and Jolanda Jetten in Group Processes & Intergroup Relations
Ophthalmotoxicity induced by antibody-drug conjugates: a pharmacovigilance study of the FDA adverse event reporting system (FAERS)
Creators: name: Zhao, Wenxia
name: Feng, Xin
name: Yang, Shan
name: Yuan, Guosen
name: Huang, Min
name: Ding, LinXiaoxiao
name: He, Zhichao
name: Wu, Junyan
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Biochemistry
Space Science
Medicine
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Science Policy
Mental Health

description: Antibody-drug conjugates (ADCs) have demonstrated remarkable therapeutic efficacy in refractory cancers, however, ophthalmotoxicity remains a serious concern. This study aimed to investigate the association between ADCs and ophthalmotoxicity. A retrospective pharmacovigilance study was conducted utilizing data extracted from the U.S. Food and Drug Administration Adverse Events Reporting System (FAERS) from 2004 to 2023. Disproportionality analyses were performed using the reporting odds ratio (ROR) and information component (IC), with sensitivity analyses and subgroup evaluations by age and sex. A total of 1992 cases of ophthalmotoxicity linked to ADCs were identified, with a median latency of 40 days. The correlation between ophthalmotoxicity and ADCs was higher than with other medications (IC = 0.67, 95% CI:0.64–0.70). Signal detection revealed 36 adverse events unreported in product labeling. Sensitivity analyses confirmed the robustness of our results on the association between ADCs and ocular toxicity, with higher reporting in females compared to males (OR = 1.25, 95% CI: 1.11–1.40). ADCs had different profiles of ophthalmotoxicity. Our pharmacovigilance study suggested increased reporting of ophthalmotoxicity associated with ADCs.
sj-pdf-1-aph-10.1177_10105395211034073 – Supplemental material for Syndemic of Tuberculosis and COVID-19 in Bangladesh
Creators: name: Hasan, Mohammad Jahid
name: Akther, Ayesha
name: Fardous, Jannatul
name: Khan, Md. Abdullah Saeed
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-1-aph-10.1177_10105395211034073 for Syndemic of Tuberculosis and COVID-19 in Bangladesh by Mohammad Jahid Hasan, Ayesha Akther, Jannatul Fardous and Md. Abdullah Saeed Khan in Asia Pacific Journal of Public Health
Robert Henryson: From Morall Fabillis of Esope the Phrygian
Creators: HC User
Publisher: name: Humanities Commons
Year: 2018
Subjects: subject: Scottish literature
subject: Rhetoric
subject: Middle Ages
subject: Printing--Social aspects
subject: Teaching
subject: Translating and interpreting
subject: Poetics

description: This is the pre-publication version of my edition of the selected fables of Robert Henryson. It is now published in an online supplement to The Broadview Anthology of British Literature. Volume 1: The Medieval Period. Ed. Joseph Black, et al. 3rd edition. Toronto: Broadview Press, 2015; revised and expanded, 2018. http://sites.broadviewpress.com/bablonline/sample-page/vol-1-the-medieval-period/.
Adverse event of ruxolitinib cream: a real-world analysis based on FDA Adverse Event Reporting System from 2021 to 2024
Creators: name: Zhou, Shu
name: Lei, Li
name: Jiang, Ling
name: Fu, Chuhan
name: Huang, Jiangfeng
name: Zhang, Keyi
name: Wen, Yaqing
name: Chen, Jing
name: Zeng, Qinghai
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Mental Health

description: Ruxolitinib cream, a topical Janus kinase (JAK) inhibitor, is a widely used treatment for various dermatological diseases. This study employs the FDA Adverse Event Reporting System (FAERS) database to examine adverse events (AEs) associated with ruxolitinib cream. This study employed disproportionate analysis methods, including reported odds ratio and proportional reporting ratio, to collate AEs reported from the fourth quarter of 2021 to the first quarter of 2024. After data processing, 803 reports involving ruxolitinib cream were analyzed. Statistically significant signals were identified for 4 system organ classes (SOCs) and 29 preferred terms (PTs). The most notable signal observed in the SOCs was associated with skin and subcutaneous tissue disorders. For PTs, the AEs observed included clinical symptoms such as pruritus, skin irritation, and burning sensations, as well as signs such as rash, scratching, erythema, and dry skin. Additionally, other observed AEs included diseases such as acne, drug hypersensitivity, and herpes zoster. This study offers insights into the safety of ruxolitinib cream, improving understanding of its AEs and guiding safer clinical practices. However, the FAERS database lacks data on AE severity and the ability to establish causality, requiring further research to clarify mechanisms behind certain AEs.
Storage Returns of Indiana Corn and Soybeans
Creators: name: Edwards, Aaron Jonathan
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Farm management, rural management and agribusiness

description: Most of Indiana corn and soybeans are placed into storage at harvest time to be delivered to market at a later date. Indiana farmers have many options regarding how and when to sell this grain. The present research addresses the issue of how to maximize the expected net returns to storage. The three central questions are: (i) which crop produces better returns? (ii) should the grain be stored unpriced or hedged using futures? and (iii) how long should grain be stored? Expected net returns for corn were maximized by storing unpriced until spring. However, unpriced corn storage provided positive returns less frequently than storage hedging. Unpriced soybean storage was better on average, and also produced positive returns more frequently than storage hedging. Returns were higher for soybeans than corn.
Robert Henryson: From Morall Fabillis of Esope the Phrygian
Creators: name: Mueller, Alex
Publisher: name: Broadview Press
Year: 2018
Subjects: subject: Scottish literature
subject: Middle Ages
subject: Translating and interpreting
subject: Rhetoric
subject: Poetics
subject: Printing--Social aspects
subject: Teaching

description: This is the pre-publication version of my edition of the selected fables of Robert Henryson. It is now published in an online supplement to The Broadview Anthology of British Literature. Volume 1: The Medieval Period. Ed. Joseph Black, et al. 3rd edition. Toronto: Broadview Press, 2015; revised and expanded, 2018. http://sites.broadviewpress.com/bablonline/sample-page/vol-1-the-medieval-period/.
Additional file 1 of Temporary slip speed increases during short-term slow slip events with durations of one to three hours
Creators: name: Katsumata, Akio
name: Miyaoka, Kazuki
name: Tsuyuki, Takahiro
name: Itaba, Satoshi
name: Tanaka, Masayuki
name: Ito, Takeo
name: Takamori, Akiteru
name: Araya, Akito
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Physical Sciences not elsewhere classified
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Additional file 1: Figure S1. Station map with station codes. The blue triangles and rectangles show the borehole and laser strainmeter locations, respectively. Epicenters of the tectonic tremors from 2016 to 2022 estimated by the method of Imanishi et al. (2011) (red circles) and S-SSE source areas from 2021 to 2022 (e.g. Japan Meteorological Agency, 2021) (black rectangles) are also shown. The black dots show the assumed fault center locations used in the stacking method.
Adverse event of ruxolitinib cream: a real-world analysis based on FDA adverse event reporting system from 2021 to 2024
Creators: name: Zhou, Shu
name: Lei, Li
name: Jiang, Ling
name: Fu, Chuhan
name: Huang, Jiangfeng
name: Zhang, Keyi
name: Wen, Yaqing
name: Chen, Jing
name: Zeng, Qinghai
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Mental Health

description: Ruxolitinib cream, a topical Janus kinase (JAK) inhibitor, is a widely used treatment for various dermatological diseases. This study employs the FDA Adverse Event Reporting System (FAERS) database to examine adverse events (AEs) associated with ruxolitinib cream. This study employed disproportionate analysis methods, including reported odds ratio and proportional reporting ratio, to collate AEs reported from the fourth quarter of 2021 to the first quarter of 2024. After data processing, 803 reports involving ruxolitinib cream were analyzed. Statistically significant signals were identified for 4 system organ classes (SOCs) and 29 preferred terms (PTs). The most notable signal observed in the SOCs was associated with skin and subcutaneous tissue disorders. For PTs, the AEs observed included clinical symptoms such as pruritus, skin irritation, and burning sensations, as well as signs such as rash, scratching, erythema, and dry skin. Additionally, other observed AEs included diseases such as acne, drug hypersensitivity, and herpes zoster. This study offers insights into the safety of ruxolitinib cream, improving understanding of its AEs and guiding safer clinical practices. However, the FAERS database lacks data on AE severity and the ability to establish causality, requiring further research to clarify mechanisms behind certain AEs.
Design of a Closed Loop System for Glaucoma Treatment including Measurement of Intraocular Pressure and Therapeutic Stimulation of the Eye
Creators: name: Swenson, Rachael
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Biomedical instrumentation

description: Glaucoma is the leading cause of irreversible blindness worldwide effecting more than 2.7 million people in the U.S alone. Treatments exist in the form of both pharmaceutical and surgical options, but often do not provide the desired efficacy. For example, the failure rate of a trabeculectomy procedure is 39% within 5 years. Additionally, none of the current glaucoma treatments allow for closed loop monitoring of pressure, therefore requiring more frequent doctor visits. Glaucoma management can be improved through the use of a closed loop application of electroceutical treatment. The goal is to develop an implantable device that will be inserted into the eye to monitor intraocular pressure (IOP) and provide responsive therapeutic stimulation to the eye. I designed a discrete pressure monitoring system that interacts with a bare die piezoresistive pressure sensor. The system is based on a Wheatstone bridge design which translates the input resistances of the pressure sensor into a voltage output. This system has an average accuracy of 0.53 mmHg and draws 295 µW of power. I then combined this pressure system with data processing code and Howland current pump stimulation circuitry. This simulation system can output up to 1.05 mA of current for electroceutical intraocular stimulation to lower IOP. Future work will involve miniaturizing the circuitries in the form of an ASIC and packaging the entire system into an ocular implant. This implant can wirelessly monitor IOP and provide therapeutic stimulation to lower IOP. A reliable, closed loop method of lowering IOP would greatly benefit the ever-growing population affected by glaucoma.
Additional file 2 of Temporary slip speed increases during short-term slow slip events with durations of one to three hours
Creators: name: Katsumata, Akio
name: Miyaoka, Kazuki
name: Tsuyuki, Takahiro
name: Itaba, Satoshi
name: Tanaka, Masayuki
name: Ito, Takeo
name: Takamori, Akiteru
name: Araya, Akito
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Physical Sciences not elsewhere classified
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Additional file 2: Figure S2. Strain change at each sensor from 21 Jan. 2019 to 19 Feb. 2019.
A real-world pharmacovigilance study of sacubitril\valsartan in older people: data mining of the FDA adverse event reporting system
Creators: name: Kuai, Zheng
name: Li, Quan
name: Zhang, Xiaoyi
name: Tang, Guowen
name: Ye, Yangli
name: Hu, Yu
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Mental Health

description: Sacubitril\valsartan is widely used in the clinical management of heart failure with reduced ejection fraction and hypertension. This study aims to systematically investigate and quantify the safety signals and potential risks associated with sacubitril\valsartan in individuals aged 65 and older, leveraging data from the FAERS database to provide insights into its real-world safety profile. Disproportionality analyses, including the reporting odds ratio (ROR), the proportional reporting ratio (PRR), the Bayesian confidence propagation neural network (BCPNN), and the multi-item gamma Poisson shrinker (MGPS) algorithms, were employed to quantify the signals of Sacubitril\valsartan-associated AEs in elderly. The search retrieved 94,210 sacubitril\valsartan-associated cases within the reporting period; 86 PTs with significant disproportionality were retained in 65 + . Reports emerged for several cognitive-related AEs and several fragility acceleration AEs, which were rare. Unexpected safety signals such as ‘Injury, poisoning, and procedural complications’ were only detected in 65 + . Most of the cases occurred within the first month after sacubitril\valsartan initiation, and this was consistent across age groups. Our study found potential new AEs signals and might provide important support for clinical monitoring and risk identification of Sacubitril\valsartan in elderly.
Additional file 3 of Temporary slip speed increases during short-term slow slip events with durations of one to three hours
Creators: name: Katsumata, Akio
name: Miyaoka, Kazuki
name: Tsuyuki, Takahiro
name: Itaba, Satoshi
name: Tanaka, Masayuki
name: Ito, Takeo
name: Takamori, Akiteru
name: Araya, Akito
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Physical Sciences not elsewhere classified
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Additional file 3: Figure S3. Stacked strain data and detection of strain steps. Every two pages show various graphs for assumed source locations shown in Fig. 1. (a) Stacked strain made from the strain data shown in Fig. S2. The assumed source location is shown at the top of the graph. Strain steps were searched for in the interval from 31 Jan. to 9 Feb. 2019 in this stacked strain time series. (b) Time series of correlation coefficients between stacked strain shown in (a) with a ramp function of 1 h rise time. (c) The same as (b) for 2 h rise time. (d) The same as (b) for 4 h rise time. (e) Detrended stacked strain of a 10-day interval. (f) Detrended accumulated number of tectonic tremors. The gray filled area in (e) and (f) indicates the interval with a high correlation between stacked strain and the ramp function of 1 or 2 h rise time (CCsr > 0.88).
A real-world pharmacovigilance study of Sacubitril\valsartan in older people: data mining of the FDA adverse event reporting system
Creators: name: Kuai, Zheng
name: Li, Quan
name: Zhang, Xiaoyi
name: Tang, Guowen
name: Ye, Yangli
name: Hu, Yu
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Mental Health

description: Sacubitril\valsartan is widely used in the clinical management of heart failure with reduced ejection fraction and hypertension. This study aims to systematically investigate and quantify the safety signals and potential risks associated with sacubitril\valsartan in individuals aged 65 and older, leveraging data from the FAERS database to provide insights into its real-world safety profile. Disproportionality analyses, including the reporting odds ratio (ROR), the proportional reporting ratio (PRR), the Bayesian confidence propagation neural network (BCPNN), and the multi-item gamma Poisson shrinker (MGPS) algorithms, were employed to quantify the signals of Sacubitril\valsartan-associated AEs in elderly. The search retrieved 94,210 sacubitril\valsartan-associated cases within the reporting period; 86 PTs with significant disproportionality were retained in 65 + . Reports emerged for several cognitive-related AEs and several fragility acceleration AEs, which were rare. Unexpected safety signals such as ‘Injury, poisoning, and procedural complications’ were only detected in 65 + . Most of the cases occurred within the first month after sacubitril\valsartan initiation, and this was consistent across age groups. Our study found potential new AEs signals and might provide important support for clinical monitoring and risk identification of Sacubitril\valsartan in elderly.
Additional file 4 of Temporary slip speed increases during short-term slow slip events with durations of one to three hours
Creators: name: Katsumata, Akio
name: Miyaoka, Kazuki
name: Tsuyuki, Takahiro
name: Itaba, Satoshi
name: Tanaka, Masayuki
name: Ito, Takeo
name: Takamori, Akiteru
name: Araya, Akito
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Physical Sciences not elsewhere classified
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Additional file 4: Figure S4. Estimation of various parameters of strain steps with CCsr > 0.88. Five or six panels are shown for each strain step. Upper left, time series of stacked strain. The vertical gray lines show the duration of the strain step. Upper center, relationship between CC $$_{\rm{sr2}}$$ sr 2 and the assumed rise time of the ramp function. The horizontal line indicates the value of $$\frac{1}{2} \log \frac{1+r}{1-r}=\frac{1}{2} \log \frac{1+r_p}{1-r_p}-\sqrt{\frac{1}{n-3}}$$ 1 2 log 1 + r 1 - r = 1 2 log 1 + r p 1 - r p - 1 n - 3 , where $$r$$ r correlation coefficient, $$r_p$$ r p peak value of $$r$$ r , and $$n$$ n number of data. The line was drawn to indicate $$r_p-$$ r p - (standard deviation of $$r$$ r ). Upper right, distribution of $$r^2$$ r 2 , where $$r^2$$ r 2 is a coefficient of determination between calculated and observed strains for the assumed source location. The ellipsoid on the map indicates a Gaussian distribution fitted to $$r^2$$ r 2 distribution. The rectangle on each map shows a fault model assumed in the strain step detection; the red line segment on the rectangle indicates the upper edge of the fault, and the green arrow indicates the slip direction. Black circles with arrows indicate the locations of strainmeters used for the analysis, and the direction of each arrow indicates the strain-sensing direction. Open circles denote the epicenters of tectonic tremors occurring during the strain step. The red dot is the average location of the plotted tremors. Lower left, relationship between calculated and observed strains at an assumed source location with the highest $$r^2$$ r 2 in the upper right map. The line denotes the result of the regression analysis. Lower center, accumulated number of tectonic tremors during the time interval shown in the upper left panel. Lower right, time series of stacked strain for the source location based on the $$r^2$$ r 2 distribution. Fault length and width were assumed to be the average of the short and long diameters of the ellipsoid in the map of the upper right panel.
Development of a Coupled Orbit-Attitude Propagator for Spacecraft of Arbitrary Geometry
Creators: name: Tamrazian, Sebastian
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Other physical sciences not elsewhere classified
High energy astrophysics and galactic cosmic rays
Astroparticle physics and particle cosmology
Aerospace engineering not elsewhere classified

description: The successful prediction of spacecraft motion is often heavily based upon assumptions used to simplify the problem without compromising solution accuracy. For many analyses, a primary assumption used is the decoupling of trajectory and attitude dynamics when calculating trajectories. In cases where spacecraft or objects have high area to mass ratios, non-conservative effects such as atmospheric drag and solar radiation pressure can greatly perturb spacecraft translational motion based on rotational state. A modular, six degree of freedom (6DOF) simulation with coupled orbit and attitude dynamics has been developed to model spacecraft and orbits of arbitrary geometries. First, the basis for the modular rotational and translational equations of motion are introduced. Next, formulations are provided for the gravity gradient torque, solar radiation pressure, aerodynamic, and non-spherical gravity potential sources of perturbations, and the Marshall Engineering Thermosphere atmospheric model used is described. A first test case is performed using the 6DOF simulation to simulate the deorbit of the spacecraft Lightsail 1, which flew in 2015. Next, predictive cases are demonstrated using the simulation for a theoretical sail-boom-rocket combination representative of a debris removal scenario, and for the Aerodynamic Deorbit Experiement, which will demonstrate a passively stable drag sail technology and characterize its effectiveness on orbit. All simulation cases have had aerodynamic perturbation formulations compared against high fidelity Direct Simulation Monte Carlo runs, and suggestions have been made for the future development of the simulation tool.
Supplemental Material, sj-docx-1-cpa-10.1177_07067437211027321 - Socioeconomic and Geographic Disparities in Emergency Department Visits due to Alcohol in Ontario: A Retrospective Population-level Study from 2003 to 2017: Disparités Socio-Économiques et Géographiques Dans les Visites au Service D’urgence en raison de L’alcool en Ontario: Une étude Rétrospective Dans la Population, de 2003 à 2017
Creators: name: Myran, Daniel
name: Hsu, Amy
name: Kunkel, Elizabeth
name: Rhodes, Emily
name: Imsirovic, Haris
name: Tanuseputro, Peter
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine

description: Supplemental Material, sj-docx-1-cpa-10.1177_07067437211027321 for Socioeconomic and Geographic Disparities in Emergency Department Visits due to Alcohol in Ontario: A Retrospective Population-level Study from 2003 to 2017: Disparités Socio-Économiques et Géographiques Dans les Visites au Service D’urgence en raison de L’alcool en Ontario: Une étude Rétrospective Dans la Population, de 2003 à 2017 by Daniel Myran, Amy Hsu, Elizabeth Kunkel, Emily Rhodes, Haris Imsirovic and Peter Tanuseputro in The Canadian Journal of Psychiatry
Thinking with Austen: Literature, Philosophy, and Anne Elliot's Inner World
Creators: name: Ostas, Magdalena
Publisher: name: Modern Language Association
Year: 2021
Subjects: subject: Fiction
subject: Austen, Jane, 1775-1817
subject: Literature--Philosophy
subject: Ethics
subject: Literature--Study and teaching

description: This essay discusses pedagogical approaches to teaching Austen's Persuasion as a novel situated at the intersection of literature and philosophy. It focuses on how Persuasion takes up, talks back to, and helps illuminate classic philosophical questions about personhood, sociality, ethics, consciousness, and the space of inner life. It discusses classroom strategies, assignments, and exercises that connect Austen's ideas about "knowledge" or "subjectivity" to more than fictions: What kinds of rhetorical and stylistic decisions does Austen make? How can we connect those decisions with her sense of what is important, knowable, and significant in the world?

No character in Austen's novels is as silently intelligent and quietly reflective as Anne Elliot, and the emphasis in my approach pivots on the class's patiently staying with her character. I show how students come to see that staging Anne's slow emergence out of the quiet discontent of her own inner world is Persuasion's central concern. As Anne comes to find forms of expression (linguistic, social, emotional, bodily) that capture the impulses of her rich inner life, she also takes on the dimensions of a heroine. Our classroom inquiry centers on what Austen wants to suggest about personhood, subjectivity, acknowledgment, and love through this unveiling of a character.
sj-pdf-2-cjk-10.1177_20543581211030396 – Supplemental material for Re-Envisioning the Canadian Nephrology Trials Network: A Can-SOLVE-CKD Stakeholder Meeting of Patient Partners and Researchers
Creators: name: Murdoch, Alicia
name: Tennankore, Karthik K.
name: Bohm, Clara
name: Clase, Catherine M.
name: Levin, Adeera
name: Vorster, Hans
name: Suri, Rita S.
Publisher: name: SAGE Journals
Year: 2021
Subjects: Medicine

description: Supplemental material, sj-pdf-2-cjk-10.1177_20543581211030396 for Re-Envisioning the Canadian Nephrology Trials Network: A Can-SOLVE-CKD Stakeholder Meeting of Patient Partners and Researchers by Alicia Murdoch, Karthik K. Tennankore, Clara Bohm, Catherine M. Clase, Adeera Levin, Hans Vorster and Rita S. Suri in Canadian Journal of Kidney Health and Disease
Post-marketing safety of pimavanserin: a real-world pharmacovigilance study based on the FDA adverse event reporting system (FAERS)
Creators: name: Liu, Dong
name: Zhang, Xueni
name: Xu, Haiyan
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Mental Health

description: Pimavanserin is a new non-dopamine neurotransmitter antipsychotic drug. This study aimed to conduct a post-marketing pharmacovigilance study of pimavanserin, through data mining technology using the FDA Adverse Event Reporting System (FAERS) database. We analyzed adverse event reports for patients using pimavanserin. Data were classified using systematic organ classification (SOC) and preferred term (PT) of the Medical Dictionary for Regular Activities (MedDRA). Four signal algorithms [reporting odds ratio (ROR), proportional reporting ratio (PRR), multi-item gamma poisson shrinker (MGPS), and bayesian confidence propagation neural network (BCPNN)] were used to detect positive signals, and the median time-to-onset was determined. Adverse drug events (ADEs) related to pimavanserin (n = 31,852) were analyzed, exhibiting an annual linear upward trend (p = 0.027). The ADEs involved 27 SOCs, but only ‘Psychiatric disorders’ simultaneously satisfied four algorithms. Overall, 153 PTs simultaneously satisfied four algorithms. Subgroup analysis of differences in the top 30 signal intensity PTs according to sex yielded significant results for seven PTs (p < 0.05). The median time-to-onset was 97 days, the highest proportion occurred within the first 30 days (31.79%). Some new PT signals not listed in the label were identified, and some PT signals showed differences according to sex.
sj-pdf-1-mav-10.1177_17568293211016817 - Supplemental material for A new nonlinear lifting line method for aerodynamic analysis and deep learning modeling of small unmanned aerial vehicles
Creators: name: Karali, Hasan
name: Inalhan, Gokhan
name: Umut Demirezen, M
name: Adil Yukselen, M
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies

description: Supplemental material, sj-pdf-1-mav-10.1177_17568293211016817 for A new nonlinear lifting line method for aerodynamic analysis and deep learning modeling of small unmanned aerial vehicles by Hasan Karali, Gokhan Inalhan, M Umut Demirezen and M Adil Yukselen in International Journal of Micro Air Vehicles
Zukünftiger Qualifikationsbedarf in der Pflege
Creators: name: Schüler, G.
name: Klaes, Lothar
name: Rommel, Alexander
name: Schröder, H.
name: Köhler, T.
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2013
Subjects: subject: Pflegepersonal
subject: Häusliche Pflege
subject: Delegation
subject: Ausbildung
subject: Krankenpflege
subject: Delphi-Technik
subject: Nursing staff
subject: Home care services
subject: Nursing education
subject: Delphi technique
subject: 610 Medizin

description: Demografischer Wandel, medizinischer Fortschritt und Versorgungsinnovationen verändern auch in der Pflege die beruflichen Qualifikationserfordernisse. Deren künftige Trends frühzeitig zu ermitteln war Ziel einer Delphi-Studie im Rahmen der FreQueNz – Initiative des BMBF. Qualitativen Experteninterviews folgte eine dreistufige Erhebung mit 243 Befragten in der zentralen zweiten Delphi-Welle. Aus Expertensicht wird in der ambulanten Versorgung Älterer eine Ausdifferenzierung der Unterstützungs- und Beratungsangebote sowie der Palliativversorgung erfolgen, die in beträchtlichem Umfang den Ausbau spezieller Qualifikationen (z. B. Intensivpflege) erfordern. Daneben steigt der Bedarf an interprofessionell, intersektoral und interkulturell ausgerichteten Koordinations- und Kommunikationskompetenzen. In der ambulanten und stationären Versorgung werden sich – unter anderem durch Übertragung ärztlicher Tätigkeiten – neue Aufgaben für Fachkräfte ergeben, z. B. in den Bereichen Assessment, Diagnostik, Therapie und Patientenschulung. Diese erfordern verstärkt Qualifikationsanpassungen wie auch die Fähigkeit zu Evidenzbasierung und Leitlinienorientierung. Folglich wird sich das System pflegerischer Berufe durch Fort-, Weiterbildung und Akademisierung weiter ausdifferenzieren.
description: Demographic change, advances in medicine, and innovative health care services are leading to changes in the professional qualification requirements for nursing and care staff. Detecting future trends in relation to these requirements was the focus of a Delphi study developed as part of the BMBF FreQueNz initiative. After qualitative expert interviews, data collection was organized in three consecutive steps, with 243 interviews realized in the second wave. It was found that home care will further diversify in the fields of supporting and counseling services as well as in palliative care, resulting in the necessary expansion of specific qualifications (e.g., intensive care). Moreover, there will be an increased need for interprofessional, intersectoral, and intercultural coordination and communication skills. As a consequence of the delegation of medical tasks, new duties for nonmedical professions in inpatient and outpatient care will also arise. For instance, qualifications need to be tailored to the new demands of assessment, diagnostics, therapy, and patient education and they should take into account evidence-based knowledge as well as clinical practice guidelines. Consequently, the system of care professionals will further diversify through advanced training programs and the continued academization of nursing.
Leishmania spp. proteome data sets: a comprehensive resource for vaccine development to target visceral leishmaniasis
Creators: name: Aebischer, Toni
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2014
Subjects: subject: proteome
subject: T cell antigen receptor
subject: vaccine
subject: kinetoplastida
subject: major histocompatibility complex antigens
subject: 610 Medizin

description: Visceral leishmaniasis is a neglected infectious disease caused primarily by Leishmania donovani and Leishmania infantum protozoan parasites. A significant number of infections take a fatal course. Drug therapy is available but still costly and parasites resistant to first line drugs are observed. Despite many years of trial no commercial vaccine is available to date. However, development of a cost effective, needle-independent vaccine remains a high priority. Reverse vaccinology has attracted much attention since the term has been coined and the approach tested by Rappuoli and colleagues. This in silico selection of antigens from genomic and proteomic data sets was also adapted to aim at developing an anti-Leishmania vaccine. Here, an analysis of the efforts is attempted and the challenges to be overcome by these endeavors are discussed. Strategies that led to successful identification of antigens will be illustrated. Furthermore, these efforts are viewed in the context of anticipated modes of action of effective anti-Leishmania immune responses to highlight possible advantages and shortcomings.
Free Digital Resources for Online Language Teaching, Learning and Course Management
Creators: name: Fees, Joseph
Publisher: name: Humanities Commons
Year: 2021
Subjects: subject: Language and languages--Study and teaching
subject: Technology

description: This guide gives a comprehensive list of free and affordable apps and websites for online language teaching.  The following digital resources are recommended websites and apps that are user-friendly programs for both students and instructors.  These tools can aid in better language learning in an online format and this guide gives some best practices for how to employ these programs strategically in an online classroom.  Instructors can utilize these resources to build more interactive assignments, develop low-stakes activities or add more presence and flare to an online student-centered language course.
Survey of pediatricians in Germany reveals important challenges for possible implementation of meningococcal B vaccination
Creators: name: Takla, Anja
name: Wichmann, Ole
name: Koch, Judith
name: Terhardt, Martin
name: Hellenbrand, Wiebke
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2014
Subjects: subject: Practice
subject: Germany
subject: Humans
subject: Female
subject: Male
subject: Cross-Sectional Studies
subject: Middle Aged
subject: Immunization Schedule
subject: Health Knowledge Attitudes
subject: Meningococcal Infections/prevention & control
subject: Meningococcal Vaccines/administration & dosage
subject: Physicians/psychology
subject: Practice Patterns Physicians
subject: Vaccination/psychology
subject: 610 Medizin

description: Incidence of invasive meningococcal disease is low in Germany at 0.5 cases/100,000 inhabitants. Serogroup B (MenB) is most common, causing 70% of cases, with highest incidence in infants (5.9/100,000). In 2013, a MenB vaccine was licensed in Europe. To assess pediatricians’ attitudes towards MenB vaccination and its potential use in Germany we conducted a nationwide cross-sectional survey among 5677 pediatricians. Of 3107 participants (response: 55%), 79.1% would recommend a MenB vaccination to parents, with 66.7% favoring a schedule at 6, 8 and 12 months over 2, 3, 4 and 12 months (13.4%). Administration separately from other vaccines was preferred (63.2%); 38.5% feared that a recommendation would lead to refusal of other recommended vaccinations. In conclusion, pediatricians showed distinct preferences regarding possible integration of MenB vaccination into the existent immunization schedule. As physicians play a crucial role in the implementation, findings will be useful in decision-making regarding potential introduction.
Supplemental Material, sj-pdf-1-tva-10.1177_15248380211029398 - Understanding the Components and Determinants of Police Attitudes Toward Intervention in Intimate Partner Violence Against Women: A Systematic Review
Creators: name: Serrano-Montilla, Celia
name: Lozano, Luis M.
name: Alonso-Ferres, María
name: Valor-Segura, Inmaculada
name: Padilla, Jose-Luis
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law

description: Supplemental Material, sj-pdf-1-tva-10.1177_15248380211029398 for Understanding the Components and Determinants of Police Attitudes Toward Intervention in Intimate Partner Violence Against Women: A Systematic Review by Celia Serrano-Montilla, Luis M. Lozano, María Alonso-Ferres, Inmaculada Valor-Segura and Jose-Luis Padilla in Trauma, Violence, & Abuse
Virulence from vesicles: Novel mechanisms of host cell injury by Escherichia coli O104:H4 outbreak strain
Creators: name: Kunsmann, Lisa
name: Rüter, Christian
name: Bauwens, Andreas
name: Greune, Lilo
name: Glüder, Malte
name: Kemper, Björn
name: Fruth, Angelika
name: Wai, Sun Nyunt
name: He, Xiaohua
name: Lloubes, Roland
name: Schmidt, M. Alexander
name: Dobrindt, Ulrich
name: Mellmann, Alexander
name: Karch, Helge
name: Bielaszewska, Martina
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2015
Subjects: subject: Humans
subject: Escherichia coli Infections/microbiology
subject: Species Specificity
subject: Disease Outbreaks
subject: Cells Cultured
subject: Escherichia coli/classification
subject: Caco-2 Cells
subject: Virulence Factors/metabolism
subject: Bacterial Outer Membrane Proteins
subject: Escherichia coli/physiology
subject: Extracellular Vesicles
subject: HT29 Cells
subject: Intestinal Mucosa/microbiology
subject: Intestinal Mucosa/pathology
subject: Shiga Toxin/metabolism
subject: 610 Medizin

description: The highly virulent Escherichia coli O104:H4 that caused the large 2011 outbreak of diarrhoea and haemolytic uraemic syndrome secretes blended virulence factors of enterohaemorrhagic and enteroaggregative E. coli, but their secretion pathways are unknown. We demonstrate that the outbreak strain releases a cocktail of virulence factors via outer membrane vesicles (OMVs) shed during growth. The OMVs contain Shiga toxin (Stx) 2a, the major virulence factor of the strain, Shigella enterotoxin 1, H4 flagellin, and O104 lipopolysaccharide. The OMVs bind to and are internalised by human intestinal epithelial cells via dynamin-dependent and Stx2a-independent endocytosis, deliver the OMV-associated virulence factors intracellularly and induce caspase-9-mediated apoptosis and interleukin-8 secretion. Stx2a is the key OMV component responsible for the cytotoxicity, whereas flagellin and lipopolysaccharide are the major interleukin-8 inducers. The OMVs represent novel ways for the E. coli O104:H4 outbreak strain to deliver pathogenic cargoes and injure host cells.