cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Curculigosides J–K and curcorchidihydrobenzofuran A, a dihydrobenzofuran with anti-proliferative properties from Curculigo orchioides
Creators: name: Saentao, Phornnapa
name: Schevenels, Florian T.
name: Yahuafai, Jantana
name: Joompang, Anupong
name: Suebrasri, Thanapat
name: Boonlue, Sophon
name: Tontapha, Sarawut
name: Lekphrom, Ratsami
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Phytochemical investigation of the rhizomes and the leaves of Curculigo orchioides led to the isolation of fourteen compounds. They consist of one undescribed dihydrobenzofuran, curcorchidihydrobenzofuran A (1), two undescribed benzyl benzoate glycosides, curculigoside J (2) and K (3), and eleven known compounds (4–14). The structures of the isolated compounds were elucidated by thorough analysis of spectroscopic (IR, NMR and ECD) and spectrometric (MS) data. Compound 1 displayed significant anti-proliferative activities against cervical cancer cells (HelaS3, IC50 = 3.6 µM) and breast cancer cells (MCF-7, IC50 = 13.9 µM) while showing moderate activities against lung cancer cells (A549, IC50 = 29.8 µM). Importantly, it was non-toxic to Vero cells. Compound 1 also inhibited the tyrosinase enzyme in a moderate manner (IC50 = 120.8 µM). Eventually, its permethylated synthetic analog 1a showed a significant suppression of lipopolysaccharide (LPS)-induced NO production in murine macrophage RAW 264.7 (IC50 = 23.4 µM).
Neufeld Karl Heinz: Probleme und Perspektiven dogmatischer Theologie. Bearbeiter und Herausgeber der dt. Ausgabe Lothar Ulrich. Düsseldorf: Patmos, 1986
Creators: name: Schütz, G.
Publisher: name: Münchener Theologische Zeitschrift
Year: 2016

description: Münchener Theologische Zeitschrift, Bd. 39, Nr. 2 (1988)
Pfeiffer, Ehrenfried: Die Fruchtbarkeit der Erde. Dornach, Rudolf Geering-Verlag 1969. 332 Seiten, Fr. 26.50.
Creators: name: Poppelbaum, Hermann
Publisher: name: Naturwissenschaftliche Sektion am Goetheanum, Elemente der
 Naturwissenschaft
Year: 1970

description: Elemente der Naturwissenschaft 12, p. 44-44.
description:
Die Naturwissenschaftliche Sektion am Goetheanum gibt dieses Buch in nunmehr fünfter, neu durchgesehener und um ein Nachwort (von Prof. Dr. Herbert Köpf) erweiterter Auflage heraus. Es ist ein Vermächtnis Dr. h. c. Ehrenfried Pfeiffers, des 1961 verstorbenen unermüdlichen Pioniers der biologisch-dynamischen Wirtschaftsweise. Das Buch ist trotz des wachsenden Abstandes der Jahre seit Seinem ersten Erscheinen (1938) immer gleich aktuell geblieben. Es hat die bezeichnende Prägung von seinem Verfasser erhalten, in dem der Landwirt und der Forscher eins gewesen sind. Alle, die ihn kannten, wissen auch, dass ihn Wissen und Tun bis in die Fingerspitzen durchdrang. [...]

description:
Die Naturwissenschaftliche Sektion am Goetheanum gibt dieses Buch in nunmehr fünfter, neu durchgesehener und um ein Nachwort (von Prof. Dr. Herbert Köpf) erweiterter Auflage heraus. Es ist ein Vermächtnis Dr. h. c. Ehrenfried Pfeiffers, des 1961 verstorbenen unermüdlichen Pioniers der biologisch-dynamischen Wirtschaftsweise. Das Buch ist trotz des wachsenden Abstandes der Jahre seit Seinem ersten Erscheinen (1938) immer gleich aktuell geblieben. Es hat die bezeichnende Prägung von seinem Verfasser erhalten, in dem der Landwirt und der Forscher eins gewesen sind. Alle, die ihn kannten, wissen auch, dass ihn Wissen und Tun bis in die Fingerspitzen durchdrang. [...]
Thymic epithelial cell responses to the friedelin triterpene in vitro
Creators: name: Porto, Felipe Lima
name: Lins, Marvin Paulo
name: Smaniotto, Salete
name: dos Santos Reis, Maria Danielma
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Hematology

description: Thymic epithelial cells (TECs) dysfunction can lead to disorders in the adaptive immune response, resulting in immunodeficiency or autoimmune diseases. Therefore, the investigation of new drugs with immunomodulatory capacity can contribute to the development of strategies to improve thymic functions. In this context, this study aimed to investigate the in vitro effects of the pentacyclic triterpene friedelin (FD) on TEC biology. For this, murine 2BH4 cells were treated with 0.1 and 1 μM FD for 24 h. After treatment, fibronectin and laminin production was increased (16% and 37% respectively) by TECs, however it did not alter the expression of CXCL12 chemokine. The interaction between TEC and thymocytes was also evaluated, in which a greater adhesion (45%) and survival (228%) of thymocytes to treated-TECs was observed. MHC molecules were up-regulated by FD treatment plus thymocyte coculture. Based on these results it was possible to attest that FD has an important and promissory role in the physiology of murine TECs.
Witt, P. N., Reed, C. F. and Peakall, D. B.: A Spider’s Web. Problems in Regulatory Biology. Berlin - Heidelberg - New York, Springer-Verlag 1968. With 47 figures. VIII, 107 pages. Cloth DM 36,-.
Creators: name: Bockemühl, Jochen
Publisher: name: Naturwissenschaftliche Sektion am Goetheanum, Elemente der
 Naturwissenschaft
Year: 1970

description: Elemente der Naturwissenschaft 12, p. 44-44.
description:
Das Buch handelt von Netzformen der Spinnen und ihren anatomischen und physiologischen Grundlagen. Schon in der geschichtlichen Einleitung wird die merkwürdige Erscheinung vorangestellt, dass sich die typische Netzgestalt in charakteristischer Weise verändert, wenn den Spinnen Drogen eingegeben werden. Diese Erscheinung steht auch im Zentrum der Untersuchungen.

Es handelt sich ursprünglich um eine Zufallsentdeckung. Als sich Prof. Hans Peters 1948 in Tübingen unter gestaltpsychologischen Aspekten mit den Spinnen beschäftigte, beabsichtigte er mit den Drogengaben nur eine zeitliche Verschiebung des Netzbaues, um diesen bequemer beobachten zu können. Anstatt dessen traten aber Gestaltveränderungen auf.

Die Autoren des vorliegenden Buches bringen eine Erweiterung der Arbeiten von Peters in systematischer und kausalanalytischer Hinsicht. Leider wurde der Blick auf die gestaltpsychologischen Probleme und auf den Aussagewert der Formen aufgegeben. Trotzdem kann der Leser bemerken, dass hier Ansätze für eine neue Art «Bildschaffender Methoden» gegeben sind.

description:
Das Buch handelt von Netzformen der Spinnen und ihren anatomischen und physiologischen Grundlagen. Schon in der geschichtlichen Einleitung wird die merkwürdige Erscheinung vorangestellt, dass sich die typische Netzgestalt in charakteristischer Weise verändert, wenn den Spinnen Drogen eingegeben werden. Diese Erscheinung steht auch im Zentrum der Untersuchungen.

Es handelt sich ursprünglich um eine Zufallsentdeckung. Als sich Prof. Hans Peters 1948 in Tübingen unter gestaltpsychologischen Aspekten mit den Spinnen beschäftigte, beabsichtigte er mit den Drogengaben nur eine zeitliche Verschiebung des Netzbaues, um diesen bequemer beobachten zu können. Anstatt dessen traten aber Gestaltveränderungen auf.

Die Autoren des vorliegenden Buches bringen eine Erweiterung der Arbeiten von Peters in systematischer und kausalanalytischer Hinsicht. Leider wurde der Blick auf die gestaltpsychologischen Probleme und auf den Aussagewert der Formen aufgegeben. Trotzdem kann der Leser bemerken, dass hier Ansätze für eine neue Art «Bildschaffender Methoden» gegeben sind.
Locher-Ernst, Louis: Geometrische Metamorphosen.. Dornach, Philosophisch-Anthroposophischer Verlag am Goetheanum 1970. 112 Seiten, 78 Figuren, Lwd. Fr. 26.50.
Creators: name: Howald-Haller, Mario
Publisher: name: Naturwissenschaftliche Sektion am Goetheanum, Elemente der
 Naturwissenschaft
Year: 1971

description: Elemente der Naturwissenschaft 14, p. 62-62.
description:
Die vorliegende nützliche Sammlung von Aufsätzen Louis Lochers ist der Initiative von Ernst Schuberth zu verdanken. Sie umfasst neben einer Bearbeitung einer lückenhaften Vortragsnachschrift acht Aufsätze, die andernorts bereits veröffentlicht worden waren und eine Liste von Buch- und Fachaufsatztiteln aus dem schriftlichen Werk Louis Lochers. [...]

description:
Die vorliegende nützliche Sammlung von Aufsätzen Louis Lochers ist der Initiative von Ernst Schuberth zu verdanken. Sie umfasst neben einer Bearbeitung einer lückenhaften Vortragsnachschrift acht Aufsätze, die andernorts bereits veröffentlicht worden waren und eine Liste von Buch- und Fachaufsatztiteln aus dem schriftlichen Werk Louis Lochers. [...]
Effects of Transcranial Direct Current Stimulation (t-DCS) of the Cerebellum on Pain Perception and Endogenous Pain Modulation: a Randomized, Monocentric, Double-Blind, Sham-Controlled Crossover Study
Creators: name: Stacheneder, Regina
name: Alt, Laura
name: Straube, Andreas
name: Ruscheweyh, Ruth
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Cerebellum
subject: Neuromodulation
subject: t-DCS
subject: Pain
subject: Offset analgesia
subject: Non-invasive brain stimulation
subject: DDC 610 / Medicine & health

description: Abstract Accumulating evidence demonstrates a role of the cerebellum in nociception. Some studies suggest that this is mediated via endogenous pain modulation. Here, we used t-DCS to test the effects of modulation of cerebellar function on nociception and endogenous pain modulation. Anodal, cathodal, and sham cerebellar t-DCS were investigated in a cross-over design in 21 healthy subjects. The nociceptive flexor (RIII) reflex, conditioning pain modulation (CPM), and offset analgesia (OA) paradigms were used to assess endogenous pain modulation. Somatosensory evoked potentials (SEPs) and pain ratings were used to assess supraspinal nociception and pain perception, respectively. No significant t-DCS effects were detected when including all t-DCS types and time points (baseline, 0, 30, 60 min post t-DCS) in the analysis. Exploratory analysis revealed an increased RIII reflex size immediately after cathodal t-DCS (compared to sham, P = 0.046, η2p = 0.184), in parallel with a trend for a decrease in electrical pain thresholds (P = 0.094, η2p = 0.134), and increased N120 SEP amplitudes 30 min after cathodal compared to anodal t-DCS (P = 0.007, η2p = 0.374). OA was increased after anodal compared to sham stimulation (P = 0.023, η2p = 0.232). Exploratory results suggested that cathodal (inhibitory) cerebellar t-DCS increased pain perception and reduced endogenous pain inhibition while anodal (excitatory) t-DCS increased endogenous pain inhibition. Results are principally compatible with activation of endogenous pain inhibition by cerebellar excitation. However, maybe due to limited t-DCS skull penetration, effects were small and unlikely to be clinically significant.
Зерно расторопши в кормлении сухостойных коров
Creators: name: Милушев Р. К.
name: Шулаев Г. М.
name: Жариков В. С.
Publisher: name: Эффективное животноводство
Year: 2025
Subjects: расторопша
гепатоз
сухостойные коровы
обмен веществ
молочная продуктивность
milk thistle
hepatosis
dry cows
metabolism
milk productivity

description: Предложена кормовая добавка на основе зерна расторопши. Состав, в %: зерно расторопши – 92,76; пробиотик «профорт» – 6,00; бетаин гидрохлорид (97%) – 1,20; витамин Е (50%) – 0,04. Ее эффективность изучена на двух группах сухостойных коров-аналогов черно – пестрой породы. Контроль получал рацион хозяйства, опытная-добавку в количестве 0,4 кг в сутки на голову в течение 58 дней сухостойного периода. Использование добавки вызвало улучшение состояния печени. Подтверждением этого служил более оптимальный коэффициент Де Ритиса. У опытных животных по сравнению с контрольными, сократилось на 2,4 часа время отделения последа. Коровы, получавшие добавку, были осеменены через 44 дня после отела, а из контрольной – на 35 дней позднее. Молочная продуктивность коров, получавших добавку, была на 4,3% выше.
description: A feed additive based on milk thistle grain has been developed. Its efficiency when used in dry cows’ diets has been studied. The composition of the additive, in %: thistle grain – 92,76; probiotic “profort” – 6,00; betaine hydrochloride (97%) – 1,20; vitamin E (50%) – 0,04. The studies were conducted on two groups of dry cows-analogues of black and mottled breed. The control received farm ration, the experimental group received feed additive in the amount of 0.4 kg per day per head during 58 days of drying period. The use of the supplement caused good state of the liver. This was confirmed by a more optimal De Ritis coefficient. Compared to control animals the time of separation of the afterbirth was reduced by 2.4 hours. The animals receiving the supplement were inseminated 44 days after calving. From control animals – 35 days later. Milk productivity of cows receiving the supplement was 4.3% higher
Lamellobates (Lamellobates) molecula Berlese 1916
Creators: name: Revelo-Tobar, Harol
name: Ojeda, Margarita
name: García-Ayala, Leonardo J.
name: Palacios-Vargas, José G.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Sarcoptiformes
Oribatellidae
Lamellobates
Lamellobates molecula

description: Lamellobates (Lamellobates) molecula Berlese, 1916
 Distribution: Tropical.
 Records in Mexico: Quintana Roo.
 Biogeographic province: Yucatan Peninsula.
 Habitat: Leaf litter under trees and bushes in a secondary semi-evergreen tropical forest.
 References: Ermilov & Yurtaev (2023b): 390.
description: Published as part of Revelo-Tobar, Harol, Ojeda, Margarita, García-Ayala, Leonardo J. & Palacios-Vargas, José G., 2024, Checklist Of Oribatid Mites (Acari: Oribatida) From Mexico, pp. 1-178 in Zootaxa 5465 (1) on page 128, DOI: 10.11646/zootaxa.5465.1.1, http://zenodo.org/record/11613709
Lyttleton, R. A.: Mysteries of the Solar System. Oxford, Clarendon Press 1968, 17 Abbildungen, 10 Tafeln, 21 Tabellen, X, 261 Seiten, geb. Fr. 22.20
Creators: name: Howald-Haller, Mario
Publisher: name: Naturwissenschaftliche Sektion am Goetheanum, Elemente der
 Naturwissenschaft
Year: 1971

description: Elemente der Naturwissenschaft 14, p. 62-63.
description:
Der Verfasser hat den Titel «Mysteries of the Solar System» gewählt, um dem Leser in Erinnerung zu rufen, wie wenig wir sicher über die nächste Umgebung im Universum, nämlich unser Sonnensystem, wissen. Denn, so sagt Lyttleton «je klarer wir die Reichweite und [62] die Grenzen unseres Wissens erkennen, desto leichter können wir entscheiden, in welchem Bereich weiter zu forschen und auf welchen Wegen zu untersuchen ist» (VI).

Das Buch enthält sieben Essays, die auf einer Vorlesungsreihe beruhen: The origin of the solar system - The interior of the earth - The constitution of the terrestrial planets - The nature of comets - The origin of comets - Tektites - The discovery of Neptune. [...]

description:
Der Verfasser hat den Titel «Mysteries of the Solar System» gewählt, um dem Leser in Erinnerung zu rufen, wie wenig wir sicher über die nächste Umgebung im Universum, nämlich unser Sonnensystem, wissen. Denn, so sagt Lyttleton «je klarer wir die Reichweite und [62] die Grenzen unseres Wissens erkennen, desto leichter können wir entscheiden, in welchem Bereich weiter zu forschen und auf welchen Wegen zu untersuchen ist» (VI).

Das Buch enthält sieben Essays, die auf einer Vorlesungsreihe beruhen: The origin of the solar system - The interior of the earth - The constitution of the terrestrial planets - The nature of comets - The origin of comets - Tektites - The discovery of Neptune. [...]
A miniature artificial kidney for peritoneal dialysis
Creators: name: Wagemans, Martijn E.H.M.
name: Simonis, Frank
name: Diënty H. M.  Hazenbrink
name: Joles, Jaap A.
name: Gerritsen, Karin G. F.
Publisher: name: F1000Research
Year: 2016

description: Objectives

We are developing a miniature artificial kidney for peritoneal dialysis, based on the wearable artificial kidney developed within NEPHRON+ (EU FP7). By continuously regenerating dialysate, the device will maintain a large plasma–dialysate concentration gradient, thereby enhancing blood purification while reducing the number of exchanges. Application is envisaged at night as a bedside device. We studied efficacy of potassium, phosphate, urea and creatinine removal from peritoneal dialysate as influenced by dialysate flow and number of sorption/electro-oxidation (EO) units. In addition, we explored whether equilibration at physiological calcium, magnesium and bicarbonate concentration and at hypotonic saline concentration could prevent calcium, magnesium and bicarbonate adsorption and net sodium release, respectively.

Conclusions

Clinically relevant removal of potassium, phosphate, urea and creatinine from peritoneal dialysate (without calcium, magnesium and bicarbonate adsorption or sodium release) by the miniature artificial kidney was shown in vitro, suggesting that application of the device for peritoneal dialysate regeneration may be worth further exploring. Altering the dialysate flow did not influence removal. Applying 3 instead of 1 sorption/EO unit(s) resulted in a 2-3-fold increase in removal. Some glucose was also removed necessitating glucose infusion. Chlorine release complied with AAMI standards. Unfortunately, ammonia/-um was generated due to hydrolysis of urea, albeit at a low amount. Research aimed at increasing efficiency, preventing ammonia/-um release and biocompatibility testing is warranted.
Religion in Samuha during the Hittite period
Creators: name: Leonard, Timothy
Publisher: name: Database of Religious History (DRH)
Year: 2021

description: Šamuḫa was an ancient cultic center and regional capital in the Hittite state. Thanks to recently excavated texts, Šamuḫa can be securely identified with an archaeological site near the village of Kayalıpınar on the Kızılırmak river, in Yıldızeli district, Sivas province, Turkey. Šamuḫa was occupied since at least the early Middle Bronze Age, and it was an important site in the Assyrian trade network. Šamuḫa was an administrative center in the border region during the reign of Telipinu (ca. 1500 BCE), and served as the de facto capital of the Hittite state during the reign of Tudḫaliya III (ca. 1370 BCE). Unfortunately, we have very little information about religion in Šamuḫa prior to the Hittite period. Our knowledge of the local religious practices has increased dramatically since excavations began in Kayalıpınar in 2005. As throughout the Hittite state, their religion was polytheistic and pluralistic. Hittite texts frequently record multiple variants or local hypostases of an archetypal deity (e.g. the Storm-god of the city of Nerik). The Hittites revered anthropomorphic gods as well as natural features (such as rivers and mountains), and sometimes even divinized artificial objects. Deities worshipped in Šamuḫa came from Anatolian, Hurrian, Syrian and Mesopotamian cultural backgrounds, including divinities of local importance, major deities of the Hittite state (such as the Sun-goddess of Arinna), and gods adopted from foreign cultures. The most important figures in the local pantheon of Šamuḫa were female deities. The original patron deity of the city was a goddess named Abara. During the Hittite Empire period (ca. 1350-1200 BCE) Abara was superseded in importance by the goddess Ištar, who was most often referred to by the Hurrian divine name Šawoška. One hypostasis of Ištar called the Goddess of the Night was brought to Šamuḫa from the region of Kizzuwatna (classical Cilicia), most likely during the reign of Tudḫaliya I (ca. 1400 BCE). The Goddess of the Night was closely associated with the Elamite goddess Pirinkir. Another important goddess in the city was Ištar of the Field of Šamuḫa. Ištar of Šamuḫa was the patron deity of the late Empire period king Ḫattušili III (ca. 1280 BCE). The pantheon of Šamuḫa also included multiple hypostases of the Storm-god, such as Teššob of Šamuḫa, the Storm-god of Lightning, and Teššob of Aleppo, along with his consort Ḫebat of Aleppo. The recently discovered cultic inventory text KpT 1.36 mentions a previously unknown deity named the Glorious Sun-deity of the Field.
PowerSensor3 hardware
Creators: name: Schoonderbeek, Gijs
name: van der Vlugt, Steven
name: Romein, John
name: Oostrum, Leon
Publisher: name: ASTRON
Year: 2025
Subjects: power measurement
powersensor
hpc

description: PowerSensor3 is a hardware platform to monitor the power consumption (voltage and current) of different processing platforms.

The project excists of:

BaseBoard a PCB board on which up to 4 Sensor Modules can be plugged, a WeACT STM32F401 microprocessor module and a SPI TFT 0.96" LCD Display module.

Several Sensor Modules designed for different ranges and connections.

All footprints used in the project are stored in the Local_Library More information about the boards can be found in the Docs directory of each module.

Also refer to the PowerSensor3 documentation page for an explanation on how to set-up and use the hardware https://powersensor3.readthedocs.io/en/latest/
Additional file 1 of Acupressure in patients with seasonal allergic rhinitis: a randomized controlled exploratory trial
Creators: name: Israel, Lukas
name: Rotter, Gabriele
name: Förster-Ruhrmann, Ulrike
name: Hummelsberger, Josef
name: Nögel, Rainer
name: Michalsen, Andreas
name: Tissen-Diabaté, Tatjana
name: Binting, Sylvia
name: Reinhold, Thomas
name: Ortiz, Miriam
name: Brinkhaus, Benno
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. Study design and data assessment schedule.
Oribatella dechambrieri Mahunka 1983
Creators: name: Revelo-Tobar, Harol
name: Ojeda, Margarita
name: García-Ayala, Leonardo J.
name: Palacios-Vargas, José G.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Sarcoptiformes
Oribatellidae
Oribatella
Oribatella dechambrieri

description: Oribatella dechambrieri Mahunka, 1983
 Distribution: Neotropical
 Records in Mexico: Chiapas.
 Biogeographic province: Chiapas Highlands.
 Habitat: Soil
 References: Mahunka (1983): 294–295; Balogh & Balogh (1990): 126; Hoffmann & López-Campos (2000): 162; Hoffmann & López-Campos (2002): 276.
description: Published as part of Revelo-Tobar, Harol, Ojeda, Margarita, García-Ayala, Leonardo J. & Palacios-Vargas, José G., 2024, Checklist Of Oribatid Mites (Acari: Oribatida) From Mexico, pp. 1-178 in Zootaxa 5465 (1) on page 129, DOI: 10.11646/zootaxa.5465.1.1, http://zenodo.org/record/11613709
Incidence of subsequent malignancies after total body irradiation-based allogeneic HSCT in children with ALL – long-term follow-up from the prospective ALL-SCT 2003 trial
Creators: name: Eichinger, Anna
name: Poetschger, Ulrike
name: Glogova, Evgenia
name: Bader, Peter
name: Basu, Oliver
name: Beier, Rita
name: Burkhardt, Birgit
name: Classen, Carl-Friedrich
name: Claviez, Alexander
name: Corbacioglu, Selim
name: Deubzer, Hedwig E.
name: Greil, Johann
name: Gruhn, Bernd
name: Güngör, Tayfun
name: Kafa, Kinan
name: Kühl, Jörn-Sven
name: Lang, Peter
name: Lange, Bjoern Soenke
name: Meisel, Roland
name: Müller, Ingo
name: Sauer, Martin G.
name: Schlegel, Paul-Gerhardt
name: Schulz, Ansgar
name: Stachel, Daniel
name: Strahm, Brigitte
name: Wawer, Angela
name: Peters, Christina
name: Albert, Michael H.
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Acute lymphocytic leukaemia
subject: Medical research
subject: DDC 610 / Medicine & health

description: Abstract Total body irradiation (TBI)-based conditioning is associated with superior leukemia-free survival in children with ALL undergoing HSCT. However, the risk for subsequent malignant neoplasms (SMN) remains a significant concern. We analyzed 705 pediatric patients enrolled in the prospective ALL-SCT-BFM-2003 trial and its subsequent registry. Patients >2 years received conditioning with TBI 12 Gy/etoposide ( n  = 558) and children ≤2 years of age or with contraindications for TBI received busulfan/cyclophosphamide/etoposide ( n  = 110). The 5- and 10-year cumulative incidence of SMN was 0.02 ± 0.01 and 0.13 ± 0.03, respectively. In total, 39 SMN (34 solid tumors, 5 MDS/AML) were diagnosed in 33 patients at a median of 5.8 years (1.7–13.4), exclusively in the TBI group. Of 33 affected patients, 21 (64%) are alive at a median follow-up of 5.1 years (0–9.9) after diagnosis of their first SMN. In univariate analysis, neither age at HSCT, donor type, acute GVHD, chronic GVHD, nor CMV constituted a significant risk factor for SMN. The only significant risk factor was TBI versus non-TBI based conditioning. This analysis confirms and quantifies the increased risk of SMN in children with ALL after conditioning with TBI. Future strategies to avoid TBI will need careful tailoring within prospective, controlled studies to prevent unfavorable outcomes.
Ten patients, one ventilator: how to best allocate critical care resources during mass disaster
Creators: name: Acton, Claire
name: M McGowan
name: C Ziegler
name: Gray, Sara
Publisher: name: F1000Research
Year: 2016

description: Introduction. Any large-scale disaster may place a hospital system in a precarious position. Planning is fundamental to facilitate an equitable process for allocating scarce critical care resources, yet there is a paucity of literature guiding protocol development. We performed a scoping review of the available literature, and used this data to develop a hospital-wide policy to guide critical care resource allocation as part of the hospital emergency management planning process.

Discussion. Effective planning, prior to a disaster, is critical to saving as many lives as possible.  Based on our scoping review, we have developed a hospital-wide protocol that incorporates ethical principles and clear inclusion and exclusion criteria, to help avoid inequity and promote transparent decision-making.    Next steps include a public consultation process and review, prior to implementation testing and educational roll-out.
mAkE Taining of Trainers Report
Creators: name: Mboa Nkoudou, Thomas Hervé
name: Nkolo Ateba, Marthe Francine
name: Fadanka, Stephane
name: Nana Diapa, Yanick
name: Jafsia, Elisée
name: Dodji, Honou
name: Moboula Mokoty, Bertrand Gildas
name: Boadu Duah, Samuel
Publisher: name: Zenodo
Year: 2024

description: This is a documentation of the Train-of-Trainer events that were implemented in the context of the mAkE project in various makerspaces and fablabs in Africa and Europe. 

The Train-of-Trainer events are specialized workshops designed to equip participants with the skills and knowledge needed to effectively train others in using the Open Makerspace Toolkit (OMT). These events offer training on the toolkit’s features and functionalities, along with methodologies for delivering engaging and effective training sessions. Participants learn to understand and use the key features of the OMT, develop interactive training sessions and evaluate their training practices.
Blood transcriptomics mirror regulatory mechanisms during hibernation—a comparative analysis of the Djungarian hamster with other mammalian species
Creators: name: Cuyutupa, Valeria Rojas
name: Moser, Dominique
name: Diedrich, Victoria
name: Cheng, Yiming
name: Billaud, Jean-Noël
name: Haugg, Elena
name: Singer, Dominique
name: Bereiter-Hahn, Jürgen
name: Herwig, Annika
name: Choukér, Alexander
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: Hibernation
subject: Torpor
subject: Transcriptomics
subject: Ingenuity pathway analysis
subject: DDC 570 / Life sciences

description: AbstractHibernation enables many species of the mammalian kingdom to overcome periods of harsh environmental conditions. During this physically inactive state metabolic rate and body temperature are drastically downregulated, thereby reducing energy requirements (torpor) also over shorter time periods. Since blood cells reflect the organism´s current condition, it was suggested that transcriptomic alterations in blood cells mirror the torpor-associated physiological state. Transcriptomics on blood cells of torpid and non-torpid Djungarian hamsters and QIAGEN Ingenuity Pathway Analysis (IPA) revealed key target molecules (TMIPA), which were subjected to a comparative literature analysis on transcriptomic alterations during torpor/hibernation in other mammals. Gene expression similarities were identified in 148 TMIPA during torpor nadir among various organs and phylogenetically different mammalian species. Based on TMIPA, IPA network analyses corresponded with described inhibitions of basic cellular mechanisms and immune system-associated processes in torpid mammals. Moreover, protection against damage to the heart, kidney, and liver was deduced from this gene expression pattern in blood cells. This study shows that blood cell transcriptomics can reflect the general physiological state during torpor nadir. Furthermore, the understanding of molecular processes for torpor initiation and organ preservation may have beneficial implications for humans in extremely challenging environments, such as in medical intensive care units and in space.
Oribatella monospicus Wharton 1938
Creators: name: Revelo-Tobar, Harol
name: Ojeda, Margarita
name: García-Ayala, Leonardo J.
name: Palacios-Vargas, José G.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Sarcoptiformes
Oribatellidae
Oribatella
Oribatella monospicus

description: Oribatella monospicus Wharton, 1938
 Distribution: Mexico.
 Records in Mexico: Yucatan.
 Biogeographic province: Yucatan Peninsula.
 Habitat: Cenote. Soil.
 References: Wharton (1938): 148–149; Pearse (1945): 39; Palacios-Vargas et al. (1998): 947; Hoffmann & López-Campos (2000): 162; Hoffmann & López-Campos (2002): 276; Hoffmann et al. (2004): 259–260.
 Remarks: The description is insufficient, its validity is questionable.
description: Published as part of Revelo-Tobar, Harol, Ojeda, Margarita, García-Ayala, Leonardo J. & Palacios-Vargas, José G., 2024, Checklist Of Oribatid Mites (Acari: Oribatida) From Mexico, pp. 1-178 in Zootaxa 5465 (1) on page 129, DOI: 10.11646/zootaxa.5465.1.1, http://zenodo.org/record/11613709
Redesigning an upper-level developmental biology lab course to incorporate zebrafish and morphometric analysis
Creators: name: Lenkowski, Jenny
Publisher: name: F1000Research
Year: 2016

description: After a traditional approach to an upper-level developmental biology course did not engage the students, the course was reimagined with an ecological developmental biology (eco-devo) perspective. The goal with this shift was to foster more critical thinking in the class and allow students to apply the course material to their own interests, be it human medicine, environmental issues, or merely a desire to learn about a new area of biology. To complement the lecture portion of the course, half of the semester made use of the zebrafish research colony on campus for experiments that required the students to address eco-devo questions. To first introduce zebrafish and the methods students would be expected to apply in independent projects, the class generated a developmental time course of exposure to a chemical by having lab groups expose different stage embryos to the same chemical. Then student pairs developed and performed independent experiments that addressed an eco-devo question using morphometrics to quantify their observations. Students were provided a list of available fish lines and potential protocols that could be performed easily within a teaching lab schedule. These included a gfap:GFP transgenic line, alcian blue staining, endogenous alkaline phosphatase staining, neutral red staining, or gelatin zymography. Students were expected to use basic imaging, ImageJ, and a spreadsheet program to collect and analyze their data, all skills that are incorporated into the biology curriculum at earlier stages and were re-emphasized through this experiment as valuable skills students can use in future work. Students generally used only those resources that were provided as options rather than exploring other resources that could have worked, and the student-designed experiments were all directly related to material from the course.
Proliferation and apoptosis after whole-body irradiation: longitudinal PET study in a mouse model
Creators: name: Meindl, Maria
name: Bläske, Alexandra
name: Steiger, Katja
name: Lindner, Simon
name: Lindheimer, Felix
name: Lauber, Kirsten
name: Brix, Nikko
name: Von Ungern-Sternberg, Barbara
name: Oos, Rosel
name: Palumbo, Giovanna
name: Böning, Guido
name: Schüle, Simone
name: Majewski, Matthäus
name: Port, Matthias
name: Ziegler, Sibylle
name: Bartenstein, Peter
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: Apoptosis
subject: Proliferation
subject: PET
subject: Irradiation
subject: Medical and Health Sciences
subject: DDC 610 / Medicine & health

description: Abstract Purpose A reliable method for regional in vivo imaging of radiation-induced cellular damage would be of great importance for the detection of therapy-induced injury to healthy tissue and the choice of adequate treatment of radiation emergency patients in both civilian and military events. This study aimed to investigate in a mouse model if positron emission tomography (PET) imaging with proliferation and apoptosis markers is potentially suitable for this purpose. Methods Four groups, including twenty mice (wild-type C57BL/6) each, were whole-body irradiated with 0 Gy, 0.5 Gy, 1 Gy, and 3 Gy and examined by PET over a six-month period at defined time points. 3'-[ 18 F]fluoro-3'-deoxythymidine ([ 18 F]FLT) and 2-(5-[ 18 F]fluoropentyl)-2-methyl malonic acid ([ 18 F]ML-10) were used to visualise proliferation and apoptosis. Regional standard uptake values were compared with respect to irradiation dose over time. Histologic data and peripheral blood cell values were correlated with the PET results. Results The hematopoietic bone marrow showed a significantly increased [ 18 F]FLT signal at early time points after radiation exposure (day 3 and day 7). This correlated with blood parameters, especially leukocytes, and histological data. A significantly increased [ 18 F]FLT signal also occurred in the gastrointestinal tract and thymus at early time points. An increased [ 18 F]ML-10 signal related to irradiation doses was observed in the bone marrow on day 8, but there was a high variability of standard uptake values and no correlation with histological data. Conclusion [ 18 F]FLT showed potential to visualise the extent, regional distribution and recovery from radiation-induced cellular damage in the bone marrow, gastrointestinal tract and thymus. The potential of [ 18 F]FLT imaging to assess the extent of bone marrow affected by irradiation might be especially useful to predict the subsequent severity of hematopoietic impairment and to adapt the therapy of the bone marrow reserve. [ 18 F]ML-10 PET proved to be not sensitive enough for the reliable detection of radiation induced apoptosis.
Oribatella neonominata Subias 2004
Creators: name: Revelo-Tobar, Harol
name: Ojeda, Margarita
name: García-Ayala, Leonardo J.
name: Palacios-Vargas, José G.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Sarcoptiformes
Oribatellidae
Oribatella
Oribatella neonominata

description: Oribatella neonominata Subías, 2004
 Distribution: Neotropical and Iran.
 References: Subías (2004, 2022).
 Remarks: The record listed for Mexico by Subías (2004, 2022) is not explained.
description: Published as part of Revelo-Tobar, Harol, Ojeda, Margarita, García-Ayala, Leonardo J. & Palacios-Vargas, José G., 2024, Checklist Of Oribatid Mites (Acari: Oribatida) From Mexico, pp. 1-178 in Zootaxa 5465 (1) on page 129, DOI: 10.11646/zootaxa.5465.1.1, http://zenodo.org/record/11613709
Illies, Joachim: Zoologie des Menschen. Entwurf einer Anthropologie.. München, Piper Paperback 1971, 227 S. DM 12,80.
Creators: name: Bockemühl, Jochen
Publisher: name: Naturwissenschaftliche Sektion am Goetheanum, Elemente der
 Naturwissenschaft
Year: 1972

description: Elemente der Naturwissenschaft 16, p. 54-55.
description:
Der Verfasser, Professor der Zoologie und Ökologie in Giessen, entwirft das Bild einer neuen Anthropologie, welches sich aus einer Überschau der Resultate der vergleichenden Verhaltensforschung und der Psychologie im Blick auf seine Sonderstellung im Naturzusammenhang ergeben kann. [...]

description:
Der Verfasser, Professor der Zoologie und Ökologie in Giessen, entwirft das Bild einer neuen Anthropologie, welches sich aus einer Überschau der Resultate der vergleichenden Verhaltensforschung und der Psychologie im Blick auf seine Sonderstellung im Naturzusammenhang ergeben kann. [...]
Mende
Creators: name: Pitek, Emily
Publisher: name: Database of Religious History (DRH)
Year: 2023

description: The Mende have historically lived in Western Africa; this entry focuses on the Mende living in the vicinity of the town of Bo, Sierra Leone around the time of 1945. At this time, a section was the basic political unit and consisted of several towns and villages. A section chief held political leadership of each section, and a paramount chief led the chiefdom as a whole. Secret societies, namely the Poro and Sande, served crucial roles in transmitting social norms, rules of conduct, and performance of ritual activity. The secret societies held a close connection with certain spirits and rituals, and embodied supernatural power. The chief, although a secular figure, “acted as general patron of the more important secret societies, such as the Poro and the Sande, and was expected to sponsor the various ceremonies called for in connection with the ancestral cult and related forms of worship and propitiation” (Little, 1951:182). Supernatural beings, in addition to ancestral spirits, included non-human spirits, and a supreme high god who created the world but is said to not have an active role in the day-to-day life of humans. Because religion permeated almost all aspects of life and culture, this entry considers the religious group to be coterminous with society itself.
Измельченный экстракт даурской лиственницы улучшает продуктивные качества телят
Creators: name: Бетин А. Н.
name: Кузнецова В. А.
Publisher: name: Эффективное животноводство
Year: 2025
Subjects: даурская лиственница
телята
продуктивность
кровь
экономическая эффективность
Daurian larch
calves
productivity
blood
economic efficiency

description: В сохранении продовольственной независимости России одно из ведущих мест занимает высокая продуктивность животных, сохранность молодняка и получение чистой, в экологическом аспекте, животноводческой продукции. Однако, сдерживающим фактором в этом направлении являются различные болезни, нарушения обмена веществ, которые проявляются в результате ухудшения кормления и содержания. В последние годы наблюдаются различные внутренние незаразные болезни и, в первую очередь, патология органов желудочно-кишечного тракта, дыхания, особенно у новорожденного молодняка телят. В отдельных хозяйствах и аграрных комплексах болеют от 64 до 100% новорожденных животных и, несмотря на проводимое лечение, погибают от 25 до 50% молодняка телят и поросят.
description: In preserving food independence of Russia, one of the leading places is occupied by high productivity of animals, safety of young animals and obtaining clean, in the ecological aspect, livestock products. However, a restraining factor in this direction are various diseases, metabolic disorders, which appear as a result of deterioration of feeding and maintenance. In recent years, various internal non-communicable diseases have been observed and, first of all, pathology of the gastrointestinal tract, respiration, especially in newborn young calves. In some farms and agricultural complexes, from 64 to 100% of newborn animals are ill and, despite the treatment, from 25 to 50% of young calves and piglets die.
Briejèr, Cornelis Jan: «Silberne Schleier. Gefahren chemischer Bekämpfungsmittel.» und Graham jr., Frank: «Seit dem Stummen Frühling»
Creators: name: Bockemühl, Jochen
Publisher: name: Naturwissenschaftliche Sektion am Goetheanum, Elemente der
 Naturwissenschaft
Year: 1972

description: Elemente der Naturwissenschaft 16, p. 54-54.
description:
Briejèr: München, Biederstein Verlag 1970, XII, 274 S. Lwd. DM 19,80.

Graham jr.: München, Biederstein Verlag 1971, XVI, 317 S. Lwd. DM 24,-.

Beide Bücher beschäftigen sich mit den Folgen, die Rachel Carsons Aufruf in ihrem Buch «Der stumme Frühling» auslöste.

Briejèr als holländischer Entomologe arbeitet vor allem die Probleme, welche mit der Insektenbekämpfung mit chemischen Mitteln im Zusammenhang stehen, heraus: Gefahr der Insektenschädlinge-Resistenzbildung durch die Bekämpfung und dadurch Verstärkung dieser Gefahren, weil die Mittel wirkungslos geworden sind - Gefahr der Giftrückstände. [...]

Während Briejèr auch europäische Verhältnisse berücksichtigt, schildert Frank Graham jr. ausschliesslich die Fortsetzung der Arbeit Rachel Carsons und die Ausbreitung ihres Impulses in Amerika. Er informiert sehr gut über die menschlichen und wirtschaftlichen Schwierigkeiten, die einem durch Rachel Carsons Aufruf angeregtem Wirken entgegenstehen und zeigt an vielen typischen Beispielen, von woher dem Menschen Gefahren als Rückwirkungen auf sein eigenes Handeln drohen. [...]

description:
Briejèr: München, Biederstein Verlag 1970, XII, 274 S. Lwd. DM 19,80.

Graham jr.: München, Biederstein Verlag 1971, XVI, 317 S. Lwd. DM 24,-.

Beide Bücher beschäftigen sich mit den Folgen, die Rachel Carsons Aufruf in ihrem Buch «Der stumme Frühling» auslöste.

Briejèr als holländischer Entomologe arbeitet vor allem die Probleme, welche mit der Insektenbekämpfung mit chemischen Mitteln im Zusammenhang stehen, heraus: Gefahr der Insektenschädlinge-Resistenzbildung durch die Bekämpfung und dadurch Verstärkung dieser Gefahren, weil die Mittel wirkungslos geworden sind - Gefahr der Giftrückstände. [...]

Während Briejèr auch europäische Verhältnisse berücksichtigt, schildert Frank Graham jr. ausschliesslich die Fortsetzung der Arbeit Rachel Carsons und die Ausbreitung ihres Impulses in Amerika. Er informiert sehr gut über die menschlichen und wirtschaftlichen Schwierigkeiten, die einem durch Rachel Carsons Aufruf angeregtem Wirken entgegenstehen und zeigt an vielen typischen Beispielen, von woher dem Menschen Gefahren als Rückwirkungen auf sein eigenes Handeln drohen. [...]
Der Himmel über dem Menschen der Steinzeit. Astronomie und Mathematik in den Bauten der Megalithkulturen. Verständliche Wissenschaft, Band 106.
Creators: name: Bockemühl, Jochen
Publisher: name: Naturwissenschaftliche Sektion am Goetheanum, Elemente der
 Naturwissenschaft
Year: 1972

description: Elemente der Naturwissenschaft 16, p. 55-55.
description:
Berlin-Heidelberg-New York, Springer-Verlag 1970. 79 Abb. VIII, 153 S. Kt. DM 7,80.

Es freut mich, auf dieses Büchlein aufmerksam machen zu können, welches eine handliche Zusammenstellung der in den verschiedenen frühgeschichtlichen Steinsetzungen aufgefundenen astronomischen Ordnungsprinzipien bringt. Es wird jedem, der dem Tun der alten Priesterastronomen nachzuspüren versucht, eine grosse Hilfe sein.

Beim Lesen kommt man leicht in die Gefahr, den Geist, welcher in der Gegenwart die erstaunlichen mathematisch-astronomischen Gesetzmässigkeiten entdecken half, mit den Intentionen der Erbauer alter Steinsetzungen zu verwechseln. Macht man sich dies aber klar, so lässt sich leicht durchschauen, wie auch die Art der Resultate von den Denkformen des gegenwärtigen Forschers abhängt. Das bedeutet jedoch, dass die hier vorgeführten Resultate noch ein weites Feld ganz anderer Entdeckungen an den Resten der Steinsetzungen offen lassen, die um so reichhaltiger und sachgemässer sein werden, je mehr es gelingt, sich in die Bewusstseinshaltung der frühgeschichtlichen Menschen einzuleben. Wer schon einmal die Schwierigkeiten erlebt hat, einen solchen Weg im Anblick der anscheinend nur roh geordneten Reste derartiger Denkmäler zu finden, wird durch das Büchlein angeregt werden, auch in anderen Richtungen weiter danach zu suchen.

description:
Berlin-Heidelberg-New York, Springer-Verlag 1970. 79 Abb. VIII, 153 S. Kt. DM 7,80.

Es freut mich, auf dieses Büchlein aufmerksam machen zu können, welches eine handliche Zusammenstellung der in den verschiedenen frühgeschichtlichen Steinsetzungen aufgefundenen astronomischen Ordnungsprinzipien bringt. Es wird jedem, der dem Tun der alten Priesterastronomen nachzuspüren versucht, eine grosse Hilfe sein.

Beim Lesen kommt man leicht in die Gefahr, den Geist, welcher in der Gegenwart die erstaunlichen mathematisch-astronomischen Gesetzmässigkeiten entdecken half, mit den Intentionen der Erbauer alter Steinsetzungen zu verwechseln. Macht man sich dies aber klar, so lässt sich leicht durchschauen, wie auch die Art der Resultate von den Denkformen des gegenwärtigen Forschers abhängt. Das bedeutet jedoch, dass die hier vorgeführten Resultate noch ein weites Feld ganz anderer Entdeckungen an den Resten der Steinsetzungen offen lassen, die um so reichhaltiger und sachgemässer sein werden, je mehr es gelingt, sich in die Bewusstseinshaltung der frühgeschichtlichen Menschen einzuleben. Wer schon einmal die Schwierigkeiten erlebt hat, einen solchen Weg im Anblick der anscheinend nur roh geordneten Reste derartiger Denkmäler zu finden, wird durch das Büchlein angeregt werden, auch in anderen Richtungen weiter danach zu suchen.
Engquist, Magda: Gestaltkräfte des Lebendigen.. Die Kupferchlorid-Kristallisation. eine Methode zur Erfassung biologischer Veränderungen pflanzlicher Substanzen.
Creators: name: Koopmans, Ate
Publisher: name: Naturwissenschaftliche Sektion am Goetheanum, Elemente der
 Naturwissenschaft
Year: 1972

description: Elemente der Naturwissenschaft 16, p. 55-56.
description:
Frankfurt, Vittorio Klostermann-Verlag 1970. 214 Abb. auf 31 Tafeln. Lwd. DM 42,50.

Durch die vorliegende Veröffentlichung gibt die Verfasserin einen umfassenden Einblick in ihre Arbeiten mit der Kupferchlorid-Kristallisationsmethode. Das Prinzip dieser Methode dürfte den Lesern dieser Zeitschrift bekannt sein. Magda Engquist baut ihre Versuchsbedingungen auf eine sorgfältig ausgearbeitete Grundlage von Konzentrationsreihen auf, bei denen einerseits die Menge des Kupferchlorids, andererseits die Menge der Zusatzsubstanz bei gleichbleibender Salzmenge studiert wird. Es finden sich dann optimale Konzentrationen, bei welchen das Kristallisationsbild des reinen Kupferchlorids am stärksten «überprägt» wird. [...]

description:
Frankfurt, Vittorio Klostermann-Verlag 1970. 214 Abb. auf 31 Tafeln. Lwd. DM 42,50.

Durch die vorliegende Veröffentlichung gibt die Verfasserin einen umfassenden Einblick in ihre Arbeiten mit der Kupferchlorid-Kristallisationsmethode. Das Prinzip dieser Methode dürfte den Lesern dieser Zeitschrift bekannt sein. Magda Engquist baut ihre Versuchsbedingungen auf eine sorgfältig ausgearbeitete Grundlage von Konzentrationsreihen auf, bei denen einerseits die Menge des Kupferchlorids, andererseits die Menge der Zusatzsubstanz bei gleichbleibender Salzmenge studiert wird. Es finden sich dann optimale Konzentrationen, bei welchen das Kristallisationsbild des reinen Kupferchlorids am stärksten «überprägt» wird. [...]