cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
HPV vaccination in Africa in the COVID-19 era: a cross-sectional survey of healthcare providers’ knowledge, training, and recommendation practices
Creators: name: Fokom Domgue, Joel
name: Gnangnon, Freddy
name: Pande, Mala
name: Plante, Marie
name: Fazazi, Hicham El
name: Yu, Robert
name: Dille, Issimouha
name: Mbatani, Nomonde
name: Shete, Sanjay
name: Lecuru, Fabrice
name: Adewole, Isaac
name: Chinula, Lameck
name: Kapambwe, Sharon
name: Diomande, Mohenou Isidore
name: Tebeu, Pierre-Marie
name: Sidibe, Fatoumata
name: Diop, Mamadou
name: Kamgno, Joseph
name: Basu, Partha
name: Traore, Bangaly
name: Murenzi, Gad
name: Dangou, Jean-Marie
Publisher: name: Frontiers Media SA
Year: 2024

description: Introduction Although the burden of cervical cancer in Africa is highest, HPV vaccination coverage remains alarmingly low in this region. Providers’ knowledge and recommendation are key drivers of HPV vaccination uptake. Yet, evidence about providers’ knowledge and recommendation practices about the HPV vaccine against a backdrop of emerging vaccine hesitancy fueled by the COVID-19 pandemic is lacking in Africa. Methods A cross-sectional study was conducted in 2021–2022 among healthcare providers involved in cervical cancer prevention activities in Africa. They were invited to report prior training, the availability of the HPV vaccine in their practice, whether they recommended the HPV vaccine, and, if not, the reasons for not recommending it. Their knowledge about the HPV vaccine was assessed through self-reporting (perceived knowledge) and with three pre-tested knowledge questions (measured knowledge). Results Of the 153 providers from 23 African countries who responded to the survey (mean age: 38.5 years, SD: 10.1), 75 (54.0%) were female and 97 (63.4%) were based In countries with national HPV immunization programs. Overall, 57 (43.8%) reported having received prior training on HPV vaccine education/counseling, and 40 (37.4%) indicated that the HPV vaccine was available at the facility where they work. Most respondents (109, 83.2%) reported recommending the HPV vaccine in their practice. Vaccine unavailability (57.1%), lack of effective communication tools and informational material (28.6%), and need for adequate training (28.6%) were the most commonly reported reasons for not recommending the HPV vaccine. While 63 providers (52.9%) reported that their knowledge about HPV vaccination was adequate for their practice, only 9.9% responded correctly to the 3 knowledge questions. Conclusion To increase HPV vaccination coverage and counter misinformation about this vaccine in Africa, adequate training of providers and culturally appropriate educational materials are needed to improve their knowledge of the HPV vaccine and to facilitate effective communication with their patients and the community.
title: Ground freezing and frost heaving
Creators: name: Penner, E.
Publisher: name: National Research Council of Canada. Division of Building Research
Year: 1962
Subjects: subject: Basements and foundations
valueUri: urn:ircsubjects:IRC0320
subject: Sous-sol et fondations
valueUri: urn:ircsubjects:IRC0320
subject: frost heaving
subject: foisonnement par le gel
subject: frost penetration
subject: pénétration du gel
subject: foundation walls
subject: murs de fondation
subject: footings
subject: semelle de fondation
subject: driveways
subject: entrée (accès)

description: This Digest contains a brief description of the physical processes involved in ground freezing and frost heaving and some suggestions on ways to prevent or diminish frost damage to various structures.
The Future of Medicine is Targeted
Creators: name: Ntina, Georgia
name: Mavromanolaki, Eirini
name: Moreira, Rosa
name: Pinto, Maria
name: Herrera-Restrepo, Ramon Santiago
name: Stivaktakis, Polychronis
name: Thrapsanioti, Lydia-Nefeli
name: Landers, Fabian
name: Vliora, Maria
Publisher: name: Zenodo
Year: 2024
Subjects: healthcare
nanomedicine
innovation
targeted drud delivery

description: The Future of Medicine is Targeted! Targeted drug delivery can change the healthcare system, with huge benefits for society and the economy, plus a wave of new market opportunities.
ÉTUDE BIOMÉTRIQUE DE LA CROISSANCE RELATIVE DES PTËRYGOPODES CHEZ LA ROUSSETTE SCYUORHINUS CANICULA (L.)
Creators: name: COLLENOT, Germaine
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1969

description: For this study the claspers length has been plotted on logarithmic coordinates. In the first place during all the period of time of development, the claspers length from 834 individuals has been mesured and plotted against the total length of the animals, and on the other hand against the testis weight of hundred individuals measuring over forty centimeters of total length. The resulting points are arranged along three lines connected by discontinuities. These connections give an account of some critical periods taking place during the physiological evolution of these animals. The relative increase of claspers length includes four periods. The embryonic stage, the juvenile stage which displays from its beginning (i.e. just after hatching) the first acceleration of the growth rate of claspers in the 10 cm long animals, and the so-called maturation stage or third stage which is a discontinuity and takes place in the 30 to 40 cm long animals. During this stage a strong rise in the growth rate of claspers is to be observed and is closely related to an important increase of the testis weight. Finally after the 58 cm length is attained the animals are mature and adult and few variations can be noted in their testis and in the claspers length.
Monte Carlo Simulations of Lattice Models for Single Polymer Systems
Creators: name: Hsu, Hsiao-Ping
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Single linear polymer chains in dilute solutions under good solvent conditions are studied by Monte Carlo simulations with the pruned-enriched Rosenbluth method up to the chain length $N \sim {\cal O}(10^4)$. Based on the standard simple cubic lattice model (SCLM) with fixed bond length and the bond fluctuation model (BFM) with bond lengths in a range between $2$ and $\sqrt{10}$, we investigate the conformations of polymer chains described by self-avoiding walks (SAWs) on the simple cubic lattice, and by random walks (RWs) and non-reversible random walks (NRRWs) in the absence of excluded volume (EV) interactions. In addition to flexible chains, we also extend our study to semiflexible chains for different stiffness controlled by a bending potential. The persistence lengths of chains extracted from the orientational correlations are estimated for all cases. We show that chains based on the BFM are more flexible than those based on the SCLM for a fixed bending energy. The microscopic differences between these two lattice models are discussed and the theoretical predictions of scaling laws given in the literature are checked and verified. Our simulations clarify that a different mapping ratio between the coarse-grained models and the atomistically realistic description of polymers is required in a coarse-graining approach due to the different crossovers to the asymptotic behavior.
description: 17 pages, 16 figures
FOUR NEW SPECIES OF MEDITERRANEAN DEMOSPONGIAE AND NEW DATA ON CALLITES LACAZII SCHMIDT
Creators: name: TSURNAMAL, M.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1969

description: A description is given of five species of Demospongiae from shallow waters along the Mediterranean coast of Israel. Of these, four are new species: Didiscus styliferus, Hymerhabdia pori, Hymerhabdia reichi and Mycale sanguinea. The aberrant sponge, Callites lacazii O. Schmidt, has been encountered anew in dark underwater caves and new data are provided on its structure and habitat.
(3928) Archibald Robinson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(3929) Catherine MacLachlan
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
On the establishment of the non-native false limpet Siphonaria pectinata in Tunisia: distribution, population structure and environmental relationships
Creators: name: BOUKHICHA, Jihen
name: BEN HASSINE, Oum Kalthoum
name: TLIG-ZOUARI, Sabiha
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2015

description: The aim of this study was to supply new information on the status of the non-native Siphonaria pectinata, recently identified in the Tunisian coasts. Field surveys conducted between 2010 and 2013 across the whole Tunisian coastline (≈ 1350 km) reveled that among the 25 surveyed stations, S. pectinata has colonized 15 stations covering the entire northern coast from Tabarka to Kelibia (≈ 300 km). This continuous distribution suggests that its introduction is due to a natural progression from the West, enhanced by the current global warming. Population density and size structure seem to be clearly related to local habitat conditions. The spatial variation of the average density, ranging between 0.10 and 5.34 ind.m-2, was statistically significant. Higher densities were observed at sites marked by strong hydrodynamics and irregular substrate surface. The analysis of the size structure showed that in most stations, limpets rarely exceed 20 mm but reach 28 to 29 mm at sites characterized by moderate wave action, high pollution level and lower densities of potentially competing Patella limpets. The seasonal monitoring of the Tunisian population indicated that recruitment occurs during autumn and winter. Recruits are assumed to have hatched during spring and summer. The similarity between the breeding season of the native Spanish and non-native Tunisian S. pectinata substantiates the western Mediterranean origin of the latter. This study is a first overview of the eco-biology of S. pectinata outside of its original range of distribution. It might serve as a starting point for future monitoring of its interaction with native species and its impact on the functioning of colonized ecosystems.
Additional file 1 of Portrait of an artist at work: exploring Max Ernst’s surrealist techniques
Creators: name: Zuena, Martina
name: Pensabene Buemi, Luciano
name: Nodari, Luca
name: Subelytė, Grazina
name: Stringari, Lena
name: Campanella, Beatrice
name: Lorenzetti, Giulia
name: Palleschi, Vincenzo
name: Tomasin, Patrizia
name: Legnaioli, Stefano
Publisher: name: figshare
Year: 2022
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Additional file 1: Figure S1. Points analysed on the Kiss by the different techniques. Figure S2. Points analysed on the Garden airplane trap by the different techniques. Figure S3. Points analysed on the Entire city by the different techniques. Figure S4. Points analysed on the Zoomorphic couple by the different techniques. Figure S5. Points analysed on the Attirement of the bride by the different techniques. Figure S6. Points analysed on the Antipope by the different techniques. Figure S7.Chroma DI (1050-650, 650-550, 550-450 nm) of the Entire city: the red arrow points at the moon circle, not visible in the RGB image (yellow square). Figure S8. Spectral features of Prussian blue recognized in The Kiss: (a) in-situ Raman spectrum and (b) ER-FTIR spectrum, the absorption at 512 cm-1 is to refer to ν(ZnO). Figure S9. ER-FTIR spectra of three yellow tones in The Kiss which show the presence of silicates. Figure S10. In-situ Raman analysis of the Kiss identifying chrome yellow orange. Figure S11. In-situ Raman analysis of the Zoomorphic couple identifying iron oxide (green peaks) and lead white (blue peak). Figure S12. ER-FTIR reflection spectra showing the presence of alteration products in AP (green lines), KI (black line) ZC (red for the spectrum collected in dark tones, cyan for the one collected on light tones), VS (magenta line), GA (blue line) and EC (orange line). Zinc oxalate (magenta dashed line) was identified by the typical inverted doublet at ≈1364 and ≈1320 cm-1, attributable to the νs(CO) and by the derivative ν(OH) at ≈3400 cm-1 [1]. Instead, Zn metal soaps, probably zinc stearate (dark cyan dashed line), were rec-ognized by the sharp inverted bands at ≈1540 and ≈1395 cm-1 which can be reasonably attributed to the asymmetric and symmetric stretching of the carboxylate group in zinc stearate [2, 3, 4, 5].
Hybrid of Graphitic Carbon Nitride and Palladated Magnetic Carbon Dot: An Efficient Catalyst for Coupling Reaction
Creators: name: Heravi, Majid Mommahed
name: Mohammadi, Leila
name: Samahe Sadjadi
name: Malmir, Masoumeh
Publisher: name: figshare
Year: 2020
Subjects: subject: 30502 Natural Products Chemistry
subject: FOS: Chemical sciences
subject: 30302 Nanochemistry and Supramolecular Chemistry
subject: 30205 Non-metal Chemistry
subject: 30303 Optical Properties of Materials
subject: 30503 Organic Chemical Synthesis
subject: Organic Chemistry
subject: 30599 Organic Chemistry not elsewhere classified
subject: 30504 Organic Green Chemistry
subject: 39904 Organometallic Chemistry

description: To take advantage of the properties of graphitic carbon nitrides and carbon quantum dots, a novel hybrid system was designed based on the synthesis and palladating of magnetic carbon quantum dots followed by hydrothermal treatment with graphitic carbon nitrides. The resulting hybrid, g‐C3N4‐Pd/CQDs@Fe, was then utilized as an efficient catalyst for promoting ligand and co‐catalyst‐free Sonogashira coupling reaction under mild reaction condition in aqueous media. Not only the catalyst could catalyze the reaction of broad range of the substrates, but also it showed good recyclability and could be easily recovered by using an external magnet and reused for several times. The study of the catalytic activities of palladated graphitic carbon nitride and magnetic carbon quantum dots confirmed that the hybrid system was more efficient catalyst compared to each component.
Experimental evidence of the effects of an antimitotic agent, Colchicine, on a nematode community through a microcosm approach
Creators: name: BOUFAHJA, Fehmi
name: ISMAÏLY, Salma
name: BEYREM, Hamouda
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2015

description: An experiment was conducted to make out if an antimitotic agent, the Colchicine, may have negative effects on a nematode community from the "Rimel" beach (Bizerte bay, NE Tunisia). Three sedimentary doses of Colchicine (in Dry Weight) (1.5428 ppm, 15.428 ppm and 154.28 ppm) were tested during 30 days of exposure. Univariate analyses showed a clear decrease in terms of quantity and quality of nematodes present in Colchicine treatments compared to the control. Multivariate analyses revealed a discernible reorganization of the community evidently due to the different species sensitivities against Colchicine. The nematode species Ptycholaimellus ponticus, Theristus modicus and Kraspedonema reflectans were identified as Colchicine-sensitive, due to population reduction after treatment. The Colchicine seems acting on these species by direct epidermic contact, by internalization through cuticular pores or by ingestion of contaminated sediment particles. Our results appeared rejecting the eutely for cells of the cuticular epidermis and those of the digestive tube of Ptycholaimellus ponticus, Theristus modicus and Kraspedonema reflectans.
Twin vector fields and independence of spectra for quadratic vector fields
Creators: name: Ramirez, Valente
Publisher: name: arXiv
Year: 2015
Subjects: subject: Complex Variables (math.CV)
subject: FOS: Mathematics
subject: Primary: 37F75, Secondary: 32M25, 32S65

description: The object of this paper is to address the following question: When is a polynomial vector field on $\mathbb{C}^2$ completely determined (up to affine equivalence) by the spectra of its singularities? We will see that for quadratic vector fields this is not the case: given a generic quadratic vector field there is, up to affine equivalence, exactly one other vector field which has the same spectra of singularities. Moreover, we will see that we can always assume that both vector fields have the same singular locus and at each singularity both vector fields have the same spectrum. Let us say that two vector fields are twin vector fields if they have the same singular locus and the same spectrum at each singularity. To formalize the above claim we shall prove the following: any two generic quadratic vector fields with the same spectra of singularities (yet possibly different singular locus) can be transformed by suitable affine maps to be either the same vector field or a pair of twin vector fields. We then analyze the case of quadratic Hamiltonian vector fields in more detail and find necessary and sufficient conditions for a collection of non-zero complex numbers to arise as the spectra of singularities of a quadratic Hamiltonian vector field. Lastly, we show that a generic quadratic vector field is completely determined (up to affine equivalence) by the spectra of its singularities together with the characteristic numbers of its singular points at infinity.
description: 9 pages
Angiopoietin-like Protein 4 Inhibition of Lipoprotein Lipase: EVIDENCE FOR REVERSIBLE COMPLEX FORMATION
Creators: name: Bradford, Kira C.
name: Erie, Dorothy A.
name: Neher, Saskia B.
name: Lafferty, Michael J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Elevated triglycerides are associated with an increased risk of cardiovascular disease, and lipoprotein lipase (LPL) is the rate-limiting enzyme for the hydrolysis of triglycerides from circulating lipoproteins. The N-terminal domain of angiopoietin-like protein 4 (ANGPTL4) inhibits LPL activity. ANGPTL4 was previously described as an unfolding molecular chaperone of LPL that catalytically converts active LPL dimers into inactive monomers. Our studies show that ANGPTL4 is more accurately described as a reversible, noncompetitive inhibitor of LPL. We find that inhibited LPL is in a complex with ANGPTL4, and upon dissociation, LPL regains lipase activity. Furthermore, we have generated a variant of ANGPTL4 that is dependent on divalent cations for its ability to inhibit LPL. We show that LPL inactivation by this regulatable variant of ANGPTL4 is fully reversible after treatment with a chelator.
Tunable room-temperature ferromagnet using an iron-oxide and graphene oxide nanocomposite
Creators: name: Lin, Aigu L.
name: Rodrigues, J. N. B.
name: Su, Chenliang
name: Milletari, M.
name: Loh, Kian Ping
name: Wu, Tom
name: Chen, Wei
name: Neto, A. H. Castro
name: Adam, Shaffique
name: Wee, Andrew T. S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Magnetic materials have found wide application ranging from electronics and memories to medicine. Essential to these advances is the control of the magnetic order. To date, most room-temperature applications have a fixed magnetic moment whose orientation is manipulated for functionality. Here we demonstrate an iron-oxide and graphene oxide nanocomposite based device that acts as a tunable ferromagnet at room temperature. Not only can we tune its transition temperature in a wide range of temperatures around room temperature, but the magnetization can also be tuned from zero to 0.011 A.m$^2$/kg through an initialization process with two readily accessible knobs (magnetic field and electric current), after which the system retains its magnetic properties semi-permanently until the next initialization process. We construct a theoretical model to illustrate that this tunability originates from an indirect exchange interaction mediated by spin-imbalanced electrons inside the nanocomposite.
description: 13 pages (4 figures) of main text; 28 pages (5 figures) of supplementary information
The Evidence for Slow Migration of Neptune from the Inclination Distribution of Kuiper Belt Objects
Creators: name: Nesvorny, David
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Much of the dynamical structure of the Kuiper belt can be explained if Neptune migrated over several AU, and/or if Neptune was scattered to an eccentric orbit during planetary instability. An outstanding problem with the existing formation models is that the distribution of orbital inclinations they predicted is narrower than the one inferred from observations. Here we perform numerical simulations of Kuiper belt formation starting from an initial state with Neptune at 20 < a_{N,0} < 30 AU and a dynamically cold outer disk extending from beyond a_{N,0} to 30 AU. Neptune's orbit is migrated into the disk on an e-folding timescale 1 <= tau <= 100 Myr. A small fraction (~10^{-3}) of the disk planetesimals become implanted into the Kuiper belt in the simulations. By analyzing the orbital distribution of the implanted bodies in different cases we find that the inclination constraint implies that tau >= 10 Myr and a_{N,0} <= 25 AU. The models with tau < 10 Myr do not satisfy the inclination constraint, because there is not enough time for various dynamical processes to raise inclinations. The slow migration of Neptune is consistent with other Kuiper belt constraints, and with recently developed models of planetary instability/migration. Neptune's eccentricity and inclination are never large in these models (e_N<0.1, i_N<2 deg), as required to avoid excessive orbital excitation in the >40 AU region, where the Cold Classicals presumably formed.
description: Astronomical Journal
TWO NEW SPECIES OF PSEUDONCHUS COBB (NEMATODA, CHOANOLAIMIDAE) FROM THE BRITISH COAST
Creators: name: WARWICK, Richard M.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1969

description: Description of Pseudonchus deconincki sp. nov. and northumbriensis sp. nov. Key to the species of Pseudonchus. A new name, P. gerlachi, is proposed for P. rotundicephalus Gerlach, 1952. Cheilopseudonchus Murphy, 1964, is shown to be a synonym of Pseudonchus.
Chemotype-selective Modes of Action of κ-Opioid Receptor Agonists
Creators: name: Aubé, Jeffrey
name: Westkaemper, Richard B.
name: Vardy, Eyal
name: Roth, Bryan L.
name: Katritch, Vsevolod
name: Wu, Huixian
name: Frankowski, Kevin J.
name: Stevens, Raymond C.
name: Mosier, Philip D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The crystal structures of opioid receptors provide a novel platform for inquiry into opioid receptor function. The molecular determinants for activation of the κ-opioid receptor (KOR) were studied using a combination of agonist docking, functional assays, and site-directed mutagenesis. Eighteen positions in the putative agonist binding site of KOR were selected and evaluated for their effects on receptor binding and activation by ligands representing four distinct chemotypes: the peptide dynorphin A(1–17), the arylacetamide U-69593, and the non-charged ligands salvinorin A and the octahydroisoquinolinone carboxamide 1xx. Minimally biased docking of the tested ligands into the antagonist-bound KOR structure generated distinct binding modes, which were then evaluated biochemically and pharmacologically. Our analysis identified two types of mutations: those that affect receptor function primarily via ligand binding and those that primarily affect function. The shared and differential mechanisms of agonist binding and activation in KOR are further discussed. Usually, mutations affecting function more than binding were located at the periphery of the binding site and did not interact strongly with the various ligands. Analysis of the crystal structure along with the present results provide fundamental insights into the activation mechanism of the KOR and suggest that “functional” residues, along with water molecules detected in the crystal structure, may be directly involved in transduction of the agonist binding event into structural changes at the conserved rotamer switches, thus leading to receptor activation.
INFLUENCE DES MODIFICATIONS HYDROLOGIQUES SUR LE PEUPLEMENT DE SPHAEROMA DANS L'ÉTANG DE BERRE
Creators: name: KERAMBRUN, P.
name: SZEKIELDA, K.-H.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1969

description: The hydrographical conditions in the “Etang de Berre” have been modified intensively by the inflow of the river Durance. The most important changings are a decrease in salinity and an increase of particulate matter. The produced environment controls the distribution of Sphaeroma serratum and its instability is propitious to the establishment of numerous populations of Sphaeroma hookeri.
title: Window air leakage
Creators: name: Sasaki, J. R.
name: Wilson, A. G.
Publisher: name: National Research Council of Canada. Division of Building Research
Year: 1962
Subjects: subject: Windows
valueUri: urn:ircsubjects:IRC0390
subject: Fenêtres
valueUri: urn:ircsubjects:IRC0390
subject: air leakages
subject: fuites d'air
subject: windows
subject: fenêtre
subject: weatherstrips
subject: bourrelet d'étanchéité
subject: air tightness
subject: étanchéité à l'air
subject: ventilation

description: It is the purpose of this Digest to discuss the implications of window air leakage, its characteristics and criteria. Much that is said may be applied to air leakage around closed doors.
Two new free-living marine nematode species of Enchelidiidae from China Sea
Creators: name: JIANG, Weijun
name: WANG, Haixia
name: HUANG, Yong
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2015

description: Two new free-living marine nematode species of family Enchelidiidae: Abelbolla major sp. nov. and Polygastrophora novenbulba sp. nov. from the Yellow Sea and the East China Sea are described, respectively. Abelbolla major sp. nov. is characterized by large body with relatively shorter tail, pharynx expands gradually and evenly and not modified into bulb, spicules curved, proximal ends broad and tapered towards distal end, gubernaculum with a triangle dorsal apophysis, presence of a precloacal seta, two well developed winged precloacal supplements very large. Polygastrophora novenbulba sp. nov. is characterized by body with long and narrow cervical portion, buccal cavity divided into four chambers, pharynx with nine distinct posterior bulbs, spicules long and narrow, hooked distal end, gubernaculum simple and rodlike, six small papillar precloacal supplements in further apart. Key to the known Abelbolla species and Polygastrophora species with male are given.
(3930) Thomas Aitken Dollar
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Differences in the Regulation of K-Ras and H-Ras Isoforms by Monoubiquitination
Creators: name: Wilkerson, Emily M.
name: Dohlman, Henrik G.
name: Campbell, Sharon L.
name: Isom, Daniel G.
name: Baker, Rachael
name: Sumita, Kazutaka
name: Sasaki, Atsuo T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Ras GTPases are signaling switches that control critical cellular processes including gene expression, differentiation, and apoptosis. The major Ras isoforms (K, H, and N) contain a conserved core GTPase domain, but have distinct biological functions. Among the three Ras isoforms there are clear differences in post-translational regulation, which contribute to differences in localization and signaling output. Modification by ubiquitination was recently reported to activate Ras signaling in cells, but the mechanisms of activation are not well understood. Here, we show that H-Ras is activated by monoubiquitination and that ubiquitination at Lys-117 accelerates intrinsic nucleotide exchange, thereby promoting GTP loading. This mechanism of Ras activation is distinct from K-Ras monoubiquitination at Lys-147, which leads to impaired regulator-mediated GTP hydrolysis. These findings reveal that different Ras isoforms are monoubiquitinated at distinct sites, with distinct mechanisms of action, but with a common ability to chronically activate the protein in the absence of a receptor signal or oncogenic mutation.
Integrals for functions with values in a partially ordered vector space
Creators: name: van Rooij, Arnoud
name: van Zuijlen, Willem
Publisher: name: arXiv
Year: 2015
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics

description: We consider integration of functions with values in a partially ordered vector space, and two notions of extension of the space of integrable functions. Applying both extensions to the space of real valued simple functions on a measure space leads to the classical space of integrable functions.
LE DÉVELOPPEMENT LARVAIRE DE LILYOPSIS ROSEA (Chun, 1885) SIPHONOPHORE CALYCOPHORE, PRAYIDAE
Creators: name: CARRÉ, Claude
name: CARRÉ, Daniele
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1969

description: The main stages of the larval development of Lilyopsis rosea, Siphonophora, Prayidae, are described. During the planula stage, a caducai appendage appears, which has never been noticed in the development of the Siphonophora.
The process of formation of the exombrella and somatocyst of the larval nectophore and the différenciation of the gastrozoïd are particular.
Fluctuation Theory of Rashba Fermi Gases
Creators: name: Vyasanakere, Jayantha P.
name: Shenoy, Vijay B.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Fermi gases with generalized Rashba spin orbit coupling inducedby a synthetic gauge field have the potential of realizing many interesting states such as rashbon condensates and topological phases. Here we develop a fluctuation theory of such systems and demonstrate that beyond-Gaussian effects are essential to capture the physics of such systems. We obtain their phase diagram by constructing an approximate non-Gaussian theory. We conclusively establish that spin-orbit coupling can enhance the exponentially small transition temperature ($T_c$) of a weakly attracting superfluid to the order of Fermi temperature, paving a pathway towards high $T_c$ superfluids.
description: 6 pages, 5 figures
(3931) Christina Major
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Direct Role for the Replication Protein Treslin (Ticrr) in the ATR Kinase-mediated Checkpoint Response
Creators: name: Hassan, Bachar H.
name: Sancar, Aziz
name: Kemp, Michael G.
name: Lindsey-Boltz, Laura A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: TopBP1 (topoisomerase IIβ-binding protein 1) is a dual replication/checkpoint protein. Treslin/Ticrr, an essential replication protein, was discovered as a binding partner for TopBP1 and also in a genetic screen for checkpoint regulators in zebrafish. Treslin is phosphorylated by CDK2/cyclin E in a cell cycle-dependent manner, and its phosphorylation state dictates its interaction with TopBP1. The role of Treslin in the initiation of DNA replication has been partially elucidated; however, its role in the checkpoint response remained elusive. In this study, we show that Treslin stimulates ATR phosphorylation of Chk1 both in vitro and in vivo in a TopBP1-dependent manner. Moreover, we show that the phosphorylation state of Treslin at Ser-1000 is important for its checkpoint activity. Overall, our results indicate that, like TopBP1, Treslin is a dual replication/checkpoint protein that directly participates in ATR-mediated checkpoint signaling.
Implications of cross-axis flow for larval dispersal along mid-ocean ridges
Creators: name: MULLINEAUX, Lauren S.
name: SPEER, Kevin G.
name: THURNHERR, Andreas M.
name: MALTRUD, Matthew E.
name: VANGRIESHEIM, Annick
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2002

Abstract
Dynamic Ubiquitination of the Mitogen-activated Protein Kinase Kinase (MAPKK) Ste7 Determines Mitogen-activated Protein Kinase (MAPK) Specificity
Creators: name: Hurst, Jillian H.
name: Dohlman, Henrik G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Ubiquitination is a post-translational modification that tags proteins for proteasomal degradation. In addition, there is a growing appreciation that ubiquitination can influence protein activity and localization. Ste7 is a prototype MAPKK in yeast that participates in both the pheromone signaling and nutrient deprivation/invasive growth pathways. We have shown previously that Ste7 is ubiquitinated upon pheromone stimulation. Here, we show that the Skp1/Cullin/F-box ubiquitin ligase SCFCdc4 and the ubiquitin protease Ubp3 regulate Ste7 ubiquitination and signal specificity. Using purified components, we demonstrate that SCFCdc4 ubiquitinates Ste7 directly. Using gene deletion mutants, we show that SCFCdc4 and Ubp3 have opposing effects on Ste7 ubiquitination. Although SCFCdc4 is necessary for proper activation of the pheromone MAPK Fus3, Ubp3 is needed to limit activation of the invasive growth MAPK Kss1. Finally, we show that Fus3 phosphorylates Ubp3 directly and that phosphorylation of Ubp3 is necessary to limit Kss1 activation. These results reveal a feedback loop wherein one MAPK limits the ubiquitination of an upstream MAPKK and thereby prevents spurious activation of a second competing MAPK.
FePd$_{3}$ as a material for thermally active artificial spin ice
Creators: name: Drisko, Jasper
name: Daunheimer, Stephen
name: Cumings, John
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We introduce FePd$_{3}$ as a new material for studying thermally active artificial spin ice (ASI) systems and use it to investigate both the square and kagome ice geometries. We readily achieve perfect ground state ordering in the square lattice and demonstrate the highest yet degree of monopole charge-ordering in the kagome lattice. We find that smaller lattice constants in the kagome system generally produce larger domains of charge order. Monte Carlo simulations show excellent agreement with our data when a small amount of disorder is included in the simulation.
description: 16 pages, 6 figures
Long-term safety, tolerability, and efficacy of efgartigimod (ADAPT+): interim results from a phase 3 open-label extension study in participants with generalized myasthenia gravis
Creators: name: Vu, Tuan
name: Murai, Hiroyuki
name: Steeland, Sophie
name: Mantegazza, Renato
name: Bril, Vera
name: De Bleecker, Jan L.
name: Pasnoor, Mamatha
name: Van Hoorick, Benjamin
name: Howard, James F.
name: Peric, Stojan
name: Beydoun, Said R.
name: Guglietta, Antonio
name: Utsugisawa, Kimiaki
name: Karam, Chafic
name: The ADAPT+ Study Group
name: Meisel, Andreas
name: Verschuuren, Jan
name: T’joen, Caroline
Publisher: name: Frontiers Media SA
Year: 2024

description: Objective ADAPT+ assessed the long-term safety, tolerability, and efficacy of efgartigimod in adult participants with generalized myasthenia gravis (gMG). Methods ADAPT+ was an open-label, single-arm, multicenter, up to 3-year extension of the pivotal phase 3 ADAPT study. Efgartigimod was administered in treatment cycles of 4 intravenous infusions (one 10 mg/kg infusion per week). Initiation of subsequent treatment cycles was individualized based on clinical evaluation. Safety endpoints included incidence and severity of adverse events. Efficacy endpoints assessed disease severity using Myasthenia Gravis-Activities of Daily Living (MG-ADL) and Quantitative Myasthenia Gravis (QMG) scores. Results As of January 2022, 151 participants had rolled over to ADAPT+ and 145 had received ≥1 dose of efgartigimod, of whom, 111 (76.6%) were AChR-Ab+ and 34 (23.4%) were AChR-Ab−. Mean study duration (treatment plus follow-up) was 548 days, and participants received up to 17 treatment cycles, corresponding to 217.6 participant-years of exposure. In the overall population, 123 (84.8%) participants reported ≥1 treatment-emergent adverse event; most frequent were headache (36 [24.8%]), COVID-19 (22 [15.2%]), and nasopharyngitis (20 [13.8%]). Clinically meaningful improvement (CMI) in mean MG-ADL and QMG scores was seen as early as 1 week following the first infusion across multiple cycles in AChR-Ab+ and AChR-Ab− participants. Maximal MG-ADL and QMG improvements aligned with onset and magnitude of total IgG and AChR-Ab reductions. For AChR-Ab+ participants at any time point in each of the first 10 treatment cycles, more than 90% had a maximum reduction of ≥2 points (CMI) in MG-ADL total score; across the 7 cycles in which QMG was measured, 69.4% to 91.3% of participants demonstrated a maximum reduction of ≥3 points (CMI) in QMG total score. Many participants demonstrated improvements well beyond CMI thresholds. In AChR-Ab+ participants with ≥1 year of combined follow-up between ADAPT and ADAPT+, mean number of annualized cycles was 4.7 per year (median [range] 5.0 [0.5–7.6]). Conclusion Results of ADAPT+ corroborate the substantial clinical improvements seen with efgartigimod in ADAPT and support its long-term safety, tolerability, and efficacy, as well as an individualized dosing regimen for treatment of gMG. Clinical trial registrationhttps://classic.clinicaltrials.gov/ct2/show/NCT03770403, NCT03770403.
Depletion of essential isoprenoids and ER stress induction following acute liver-specific deletion of HMG-CoA reductase
Creators: name: De Giorgi, Marco
name: Jarrett, Kelsey
name: Burton, Jason
name: Doerfler, Alexandria
name: Hurley, Ayrea
name: Li, Ang
name: Hsu, Rachel
name: Furgurson, Mia N.
name: Patel, Kalyani
name: Han, Jun
name: Borchers, Christoph H.
name: R. Lagor, William
Publisher: name: Health Research Alliance
Year: 2023
Subjects: Cell metabolism

description: HMG-CoA reductase (Hmgcr) is the rate-limiting enzyme in the mevalonate pathway and is inhibited by statins. In addition to cholesterol, Hmgcr activity is also required for synthesizing nonsterol isoprenoids, such as dolichol, ubiquinone, and farnesylated and geranylgeranylated proteins. Here, we investigated the effects of Hmgcr inhibition on nonsterol isoprenoids in the liver. We have generated new genetic models to acutely delete genes in the mevalonate pathway in the liver using AAV-mediated delivery of Cre-recombinase (AAV-Cre) or CRISPR/Cas9 (AAVCRISPR). The genetic deletion of Hmgcr by AAV-Cre resulted in extensive hepatocyte apoptosis and compensatory liver regeneration. At the biochemical level, we observed decreased levels of sterols and depletion of the nonsterol isoprenoids, dolichol and ubiquinone. At the cellular level, Hmgcr-null hepatocytes showed ER stress and impaired N-glycosylation. We further hypothesized that the depletion of dolichol, essential for N-glycosylation, could be responsible for ER stress. Using AAV-CRISPR, we somatically disrupted dehydrodolichyl diphosphate synthase subunit (Dhdds), encoding a branch point enzyme required for dolichol biosynthesis. Dhdds-null livers showed ER stress and impaired N-glycosylation, along with apoptosis and regeneration. Finally, the combined deletion of Hmgcr and Dhdds synergistically exacerbated hepatocyte ER stress. Our data show a critical role for mevalonate-derived dolichol in the liver and suggest that dolichol depletion is at least partially responsible for ER stress and apoptosis upon potent Hmgcr inhibition.
(3924) Robert Love
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
In Vivo Gene Editing in Lipid and Atherosclerosis Research
Creators: name: De Giorgi, Marco
name: Jarrett, Kelsey
name: Vallim, Thomas
name: R. Lagor, William
Publisher: name: Health Research Alliance
Year: 2023
Subjects: Gene and molecular therapy

description: The low-density lipoprotein receptor (Ldlr) and apolipoprotein E (Apoe) germline knockout (KO) models have provided fundamental insights in lipid and atherosclerosis research for decades. However, testing new candidate genes in these models requires extensive breeding, which is highly time and resource consuming. In this chapter, we provide methods for rapidly modeling hypercholesterolemia and atherosclerosis as well as testing new genes in adult mice through somatic gene editing. Adeno-associated viral (AAV) vectors are exploited to deliver the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 genome editing system (AAV-CRISPR) to the liver. This tool enables rapid and efficient editing of lipidand atherosclerosis-related genes in the liver.
Size at maturity of female red king crab, Paralithodes camtschaticus, from the costal zone of Kola Peninsula (southern Barents Sea)
Creators: name: DVORETSKY, Alexander G.
name: DVORETSKY, Vladimir G.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2015

description: The red king crab, Paralithodes camtschaticus (Tilesius, 1815), is a large commercial species introduced in the Barents Sea. The aim of this study was to estimate the size at maturity (SM50) in female red king crab sampled at three costal sites of the Russian parts in the Barents Sea. Females were defined as sexually mature based on the observed presence of eggs or past presence of eggs (egg remains). In Sayda Bay, the SM50 was 104.0 mm carapace length (CL), this value was similar to the SM50 of females collected in Dolgaya Bay (104.2 mm CL). The highest SM50 (110.2 mm CL) was found for female crabs collected in Dalnezelenetskaya Bay. These differences in general reflect a well known pattern of inverse correlation between SM50 and water temperature which is about 1ºC lower in Dalnezelenetskaya Bay compared to other sites. Other temperature related factors as well as fishing pressure could also affect variations of SM50 observed in our study. Our SM50 levels were lower or comparable to those found in Norwegian fjords of the Barents Sea. Female red king crab appears to mature at a larger size in the Barents Sea than those found in the North Pacific Ocean.
Z2 topological liquid of hard-core bosons on a kagome lattice at 1/3 filling
Creators: name: Roychowdhury, Krishanu
name: Bhattacharjee, Subhro
name: Pollmann, Frank
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We consider hard-core bosons on the kagome lattice in the presence of short range repulsive interactions and focus particularly on the filling factor 1/3. In the strongly interacting limit, the low energy excitations can be described by the quantum fully packed loop coverings on the triangular lattice. Using a combination of tensor-product state based methods and exact diagonalization techniques, we show that the system has an extended Z2 topological liquid phase as well as a lattice nematic phase. The latter breaks lattice rotational symmetry. By tuning appropriate parameters in the model, we study the quantum phase transition between the topological and the symmetry broken phases. We construct the critical theory for this transition using a mapping to an Ising gauge theory that predicts the transition to belong to the O(3) universality class.
description: 12 pages, 10 figures
Recent advances in imaging deep-sea hydrothermal vents
Creators: name: LUTZ, Richard
name: SHANK, Timothy
name: RONA, Peter
name: REED, Andrew
name: ALLEN, Cathy
name: LANGE, W.
name: LOW, Stephen
name: KRISTOF, Emory
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2002

Abstract