cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Quasi normal modes and the area spectrum of a near extremal de Sitter black hole with conformally coupled scalar field
Creators: name: Fernando, Sharmanthie
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this paper we have studied a black hole in de Sitter space which has a conformally coupled scalar field in the background. This black hole is also known as the $MTZ$ black hole. We have obtained exact values for the quasi normal mode frequencies under massless scalar field perturbations. We have demonstrated that when the black hole is near-extremal, that the wave equation for the massless scalar field simplifies to a Schr$\ddot{o}$dinger type equation with the well known P$\ddot{o}$shler-Teller potential. We have also used 6th order WKB approximation to compute quasinormal mode frequencies to compare with exact values obtained via the P$\ddot{o}$shler-Tell method for comparison. As an application, we have obtained the area spectrum using modified Hods approach and show that it is equally spaced.
description: 12 pages
Nomadic Subjects
Creators: name: Hope, Cat
Publisher: name: Monash University
Year: 2020
Subjects: subject: 190406 Music Composition
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: These are the materials for a composition by Cat Hope entitled 'Nomadic Subjects', written for a telematic performance at Ars Electronica in 2020.You can play from the video or a .dsz score on coordinated iPads.

Designed for 6 players, 2 vision mixers, movement and audio file for 'treatment'

Nomadic Subjects” is the title of a 2011 book by Rosi Braidotti. There is a line in there, which I relate to music representation: “points of transition across the multiple geographical, ethnic, and linguistic dividing lines: they never sit still, but rather shift with incredible violence”(p31)

The piece can be performed on networked iPads over the Internet, and a max patch is provided to enable the flashing and audio file playback. Otherwise, all performers can read from a 'movie' version of the score. A set of instructions is provided to assist with reading the score.
(100722) Ethel Marie Beck
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Validity of Stokes-Einstein Relation in Soft Colloids up to the Glass Transition
Creators: name: Gupta, Sudipta
name: Stellbrink, Jörg
name: Zaccarelli, Emanuela
name: Likos, Christos N.
name: Camargo, Manuel
name: Holmqvist, Peter
name: Allgaier, Jürgen
name: Willner, Lutz
name: Richter, Dieter
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We investigate the dynamics of kinetically frozen block copolymer micelles of different softness across a wide range of particle concentrations, from the fluid to the onset of glassy behavior, through a combination of rheology, dynamic light scattering and pulsed field gradient NMR spectroscopy. We additionally perform Brownian dynamics simulations based on an ultrasoft coarse-grained potential, which are found to be in quantitative agreement with experiments, capturing even the very details of dynamic structure factors S(Q, t) on approaching the glass transition. We provide evidence that for these systems the Stokes-Einstein relation holds up to the glass transition; given that it is violated for dense suspensions of hard colloids, our findings suggest that its validity is an intriguing signature of ultrasoft interactions.
description: 5 pages, 4 figures, Supplementary Information, Accepted to Physical Review Letters (PRL) (2015)
(100724) Henry James Lethbridge Beck
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Gefangen im Labyrinth des neoliberalen Arbeitsrechts. Brüche und Kontinuitäten in Chiles Arbeitsgesetzgebung (1924–2022)
Creators: name: Fechner, Heiner
Publisher: name: Universität Bremen
Year: 2023
Subjects: subject: Chilenisches Arbeitsrecht
subject: Arbeitsrecht Chile
subject: Neoliberales Arbeitsrecht
subject: Chilenische Geschichte
subject: 980

description: Der Artikel skizziert wesentliche Entwicklungsschritte des chilenischen Arbeitsrechts von seinen Anfängen in den 1920er Jahren bis heute. Analysiert werden neben den früh angelegten Grundstrukturen wesentliche Reformen bis 1973, der neoliberale Umbruch während der Pinochet-Diktatur sowie neue Impulse nach der Diktatur, um abschließend eine Einordnung der arbeitsrechtlichen Debatten und Richtungsentscheidungen im Rahmen der Debatten um eine neue Verfassung vorzunehmen. Dabei steht die Analyse von Pfadabhängigkeiten und Brüchen mit Entwicklungspfaden der Organisation und Regulierung abhängiger Beschäftigung in Chile im Mittelpunkt.
User Manual: QualiAnon – Tool for the anonymization of text data (v1.3)
Creators: name: Nicolai, Tom
name: Mozygemba, Kati
Publisher: name: Universität Bremen
Year: 2023
Subjects: subject: anonymization
subject: pseudonymization
subject: qualitative data
subject: qualitative research
subject: Tool
subject: Qualiservice
subject: QualiAnon
subject: 300

description: The manual provides information on the development and the functions of QualiAnon - the Qualiservice-tool for the anonymization of text data.
Non-relativistic stellar structure in higher-curvature gravity: systematic construction of solutions to the modified Lane-Emden equations
Creators: name: Tonosaki, Shinpei
name: Tachinami, Tomoya
name: Sendouda, Yuuiti
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the structure of static spherical stars made up of a non-relativistic polytropic fluid in linearized higher-curvature theories of gravity (HCG). We first formulate the modified Lane-Emden (LE) equation for the stellar profile function in a gauge-invariant manner, finding it boils down to a sixth order differential equation in the generic case of HCG, while it reduces to a fourth order equation in two special cases, reflecting the number of additional massive gravitons arising in each theory. Moreover, the existence of massive gravitons renders the nature of the boundary-value problem unlike the standard LE: some of the boundary conditions can no longer be formulated in terms of physical conditions at the stellar center alone, but some demands at the stellar surface necessarily come into play. We present a practical scheme for constructing solutions to such a problem and demonstrate how it works in the cases of the polytropic index n = 0 and 1, where analytical solutions to the modified LE equations exist. As physical outcomes, we clarify how the stellar radius, mass, and Yukawa charges depend on the theory parameters and how these observables are mutually related. Reasonable upper bounds on the Weyl-squared correction are obtained.
description: 27 pages, 17 figures
Classification methods for Hilbert data based on surrogate density
Creators: name: Bongiorno, Enea G.
name: Goia, Aldo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Methodology (stat.ME)
subject: Applications (stat.AP)
subject: Computation (stat.CO)
subject: FOS: Computer and information sciences
subject: 62G99

description: An unsupervised and a supervised classification approaches for Hilbert random curves are studied. Both rest on the use of a surrogate of the probability density which is defined, in a distribution-free mixture context, from an asymptotic factorization of the small-ball probability. That surrogate density is estimated by a kernel approach from the principal components of the data. The focus is on the illustration of the classification algorithms and the computational implications, with particular attention to the tuning of the parameters involved. Some asymptotic results are sketched. Applications on simulated and real datasets show how the proposed methods work.
description: 33 pages, 11 figures, 6 tables
Atrapados en el laberinto del derecho laboral neoliberal. Rupturas y continuidades en la legislación chilena (1924–2022)
Creators: name: Fechner, Heiner
Publisher: name: Universität Bremen
Year: 2023
Subjects: subject: Derecho laboral chileno
subject: Historia del derecho laboral chileno
subject: Derecho del trabajo neoliberal
subject: Derecho laboral neoliberal
subject: 980

description: El artículo esboza las principales etapas de la evolución del derecho laboral chileno moderno desde sus inicios en la década de 1920 hasta la actualidad. Además de las primeras estructuras básicas, se analizan las reformas esenciales hasta 1973, el cambio radical neoliberal durante la dictadura de Pinochet y los nuevos impulsos después de la dictadura, para concluir con una clasificación de los debates sobre el derecho del trabajo y las decisiones de orientación en el contexto de los debates sobre una nueva constitución en 2021/22. La atención de este trabajo se centra en el análisis de las dependencias de camino y los cambios profundos en su desarrollo, incluyendo las rupturas con los paradigmas convencionales de la organización y regulación del empleo dependiente en Chile.
ASPECTS OF DATA STRUCTURE IN MACHINE LEARNING
Creators: name: ERBA, VITTORIO
Publisher: name: Universit� degli Studi di Milano
Year: 2021

description: It is widely believed that understanding data structure is a crucial ingredient to push forward our comprehension on how (and why) modern machine learning works. Still, most of the theoretical results we have are obtained under very simplifying assumptions on the structure of the training data. In this Thesis, I review some novel results on the problem of characterizing the geometric structure of datasets and the consequences that this structure has on learning algorithms. I also provide pedagogical introductions to manifold learning, random geometric graphs theory and supervised binary classification. I focus on three different aspects of the problem. First, I spend some time reviewing techniques to characterize the intrinsic dimensionality of datasets: this is the first "experimental" step towards proper theoretical modelling of data. Then, I focus on the problem of finding null models of data in high-dimension: does Euclidean structure survive when the dimensionality of data becomes larger and larger? Finally, I study how geometric data structure alters the expressive potential of simple classifiers.
On integrability of certain rank 2 sub-Riemannian structures
Creators: name: Kruglikov, Boris
name: Vollmer, Andreas
name: Lukes-Gerakopoulos, Georgios
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: Dynamical Systems (math.DS)
subject: Optimization and Control (math.OC)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We discuss the integrability of rank 2 sub-Riemannian structures on low-dimensional manifolds, and then prove that some structures of that type in dimension 6, 7 and 8 have a lot of symmetry but no integrals polynomial in momenta of low degrees, except for those coming from the Killing fields and the Hamiltonian, thus indicating non-integrability of the corresponding geodesic flows.
description: In the second version we restructured the material, improved non-existence result in dimension 7 (to degree 6 using the modular approach), and updated references. We also refined the algorithm, and we attach the corresponding commented Maple file (together with PDF outputs of its work for several cases) as the supplement
Linkage analyses of stimulant dependence, craving, and heavy use in American Indians
Creators: name: Gizer, Ian R.
name: Wilhelmsen, Kirk C.
name: Ehlers, Cindy L.
name: Gilder, David A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Amphetamine-type substances are the second most widely used illicit drugs in the United States. There is evidence to suggest that stimulant use (cocaine and methamphetamine) has a heritable component, yet the areas of the genome underlying these use disorders are yet to be identified. This study’s aims were to map loci linked to stimulant dependence, heavy use, and craving in an American Indian community at high risk for substance dependence. DSM diagnosis of stimulant dependence, as well as indices of stimulant “craving” and “heavy use”, were obtained using the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA). Genotypes were determined for a panel of 791 micro-satellite polymorphisms in 381 members of multiplex families using SOLAR. Stimulant dependence, stimulant “craving” and “heavy stimulant use”, were all found to be heritable. Analyses of multipoint variance component LOD scores, failed to yield evidence of linkage for stimulant dependence. For the stimulant “craving” phenotype, linkage analysis revealed a locus that had a LOD score of 3.02 on chromosome 15q25.3-26.1 near the nicotinic receptor gene cluster. A LOD score of 2.05 was found at this same site for “heavy stimulant use”. Additional loci with LOD scores above 2.00 were found for stimulant “craving” on chromosomes 12p13.33-13.32 and 18q22.3. These results corroborate the importance of “craving” as an important phenotype that is associated with regions on chromosome 12, 15 and 18, that have been highlighted in prior segregation studies in this and other populations for substance dependence-related phenotypes.
ESSAY ON GENDER AND FIRM PERFORMANCE
Creators: name: FIREW, BANCHAYEHU GIRMA
Publisher: name: Universit� degli Studi di Milano
Year: 2020

description: Women account for about half of the world?s population, and they generally face several barriers to participation in the labor force, run their business, and reach the higher echelon of their careers. Culture, religious views, and gender-related stereotypes are among the major identified constraints (Comi et al., 2019). A burgeoning literature in economics seeks to understand the effect of top managers? or board of directors? gender on firm performance. However, prior studies have focused on the cases of developed countries such as Italy, Norway, among others. (Comi et al., 2019; Ferreira, 2009; Flabbi et al., 2016; Kenneth and Amy, 2012). This thesis attempts to contribute to the research gap by examining the relationship between the gender of the owners or the board directors and the firm performance in two developing countries?Brazil and Malaysia. In the first chapter, I specifically focus on the role of gender in firm performance and access to credit in the case of Brazil. In the second chapter, instead, I explore the impact of gender diversification of the board of directors on firm performance in the case of Malaysia. In contrast to some studies that focus on the difference in firm performance based on the gender of owners or board directors, this study investigates multiple dimensions of firm performance. This thesis uses various firm performance metrics based on the available information in each dataset. The number of employees, total revenue, sales growth, employee growth, labor productivity, value-added per worker, and export propensity is considered for the study in case of Brazil; while total revenue, asset, profit margin, Return on Equity (ROE), and Tobin?s Q are used for the study in case of Malaysia. This thesis, therefore, provides a well-rounded and compressive analysis of the role of gender of owners or board of directors in firm performance. Further, it addresses the impact of gender diversification among the board of directors on firm performance. The majority of prior studies use cross-sectional data, making it difficult to identify causal links (Hillman et al., 2007; Julizaerma and Mohamad, 2012; Post and Byron, 2014). It also considers the influence of other factors such as age, education, and experience of board directors and investigates the existence of heterogeneous effect of gender diversification among the board of directors based on the firm size, sectors, and the status of competitiveness of the firm. Furthermore, it explores an important point that never explored in connection with gender diversification, which is the relationship between the share of directors having family relationships and firm performance. It also investigates the impact of gender diversification requirement in the Malaysian board of directors on the share of directors who have family relations.
Mutations in the TSGA14 gene in families with autism spectrum disorders
Creators: name: Korvatska, O.
name: Kohen, R.
name: Bekris, L. M.
name: Schellenberg, G. D.
name: Raskind, W. H.
name: Dawson, G.
name: Munson, J.
name: Estes, A.
name: Yu, C. E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Linkage to 7q has been the most robust genetic finding in familial autism. A previous scan of multiplex families with autism spectrum disorders found a linkage signal of genome-wide significance at D7S530 on 7q32. We searched a candidate imprinted region at this location for genetic variants in families with positive linkage scores. Using exon resequencing, we identified three rare potentially pathogenic variants in the TSGA14 gene, which encodes a centrosomal protein. Two variants were missense mutations (c.664C>G; p.P206A and c.766T>G; p.C240G) that changed conserved residues in the same protein domain; the third variant (c.192+5G>A) altered splicing, which resulted in a protein with an internal deletion of 16 residues and a G33D substitution. These rare TSGA14 variants are enriched in the affected subjects (6/348 patients versus 2/670 controls, Fisher's exact two tailed p= 0.022). This is the first report of a possible link of a gene with a centrosomal function with familial autism.
Inside a Life-Threatening Crowd: Analysis of the Love Parade Disaster from the Perspective of Eyewitnesses
Creators: name: Sieben, Anna
name: Seyfried, Armin
Publisher: name: arXiv
Year: 2023
Subjects: subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences

description: During the Love Parade disaster in 2011 in Duisburg, Germany, twenty one visitors were killed and more than five hundred injured in a very dense crowd on the route to and from the festival area. Approximately nine hundred visitors who had been among this crowd were subsequently interviewed by police officers as eyewitnesses. This paper content analyses a random sample of 136 of these witness statements, focusing on how those present perceived the crowd, how they behaved, how they experienced the event emotionally, what happened to their bodies, and which collective dynamics they described. This approach provides a perspective from within crowd dynamics which are usually observed from a top-view perspective. Almost all the attendees became strongly focused on the staircase and the pole the only visible ways out of the crowd. In some cases, they tried to reach these destinations by all means and at the expense of others. But at the same time, helping behavior is the behavior most frequently mentioned. Although witnesses described feelings of intense fear, they reject the idea of mass panic. As the most dangerous dynamics, a combination of falls (often after people had fainted) and transversal waves (which made people fall on top of each other) could be reconstructed. When people fall in a tightly packed crowd, a hole can form which pulls in more people due to the pressure on those standing around the edge of the hole, thus creating a pile of wedged bodies.
description: 29 pages, 2 figures, 1 table, content analysis of 136 witness statements, version after review process
Footprints in the sand: What can globular clusters tell us about NGC 4753 past?
Creators: name: Caso, Juan Pablo
name: Bassino, Lilia P.
name: Gómez, Matías
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: NGC 4753 is a bright (M_V approx -22.3) lenticular galaxy. It is a very interesting target to test different theories of formation of lenticular galaxies, due to its low-density environment and complex structure. We perform the first comprehensive study of NGC 4753 globular cluster system (GCS), using Gemini/GMOS and CTIO/MosaicII images. Our results indicate a rather poor GCS of approx 1000 members. Its azimuthal distribution follows the shape of the galaxy bulge. The GC colour distribution is peculiar, presenting an intermediate subpopulation in addition to blue and red ones. This intermediate subgroup can be explained by a single stellar population with an age of 1.5-3 Gyr and 0.5-1 Z_o. The GC specific frequency S_N = 1.3+/-0.15 is surprisingly low for a galaxy of its class. The GC luminosity function (GCLF) is also peculiar, with an excess of bright GCs compared to the expected gaussian distribution. The underlying galaxy body has significant substructure, with remnants of spiral arms, dust filaments, and isophote twisting. This, and the fact that NGC 4753 hosted two type Ia SNe, support the possibility that the intermediate GC subpopulation may have originated during a recent merger, 1-3 Gyr ago.
description: 10 pages, 10 figures, accepted on MNRAS
Defining genetically meaningful language and personality traits in relatives of individuals with fragile X syndrome and relatives of individuals with autism
Creators: name: Klusek, Jessica
name: Piven, Joseph
name: Parlier, Morgan
name: Sideris, John
name: Martin, Gary E.
name: Losh, Molly
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Substantial phenotypic overlap exists between fragile X syndrome (FXS) and autism, suggesting that FMR1 (the gene causing FXS) poses a significant risk for autism. Cross-population comparisons of FXS and autism therefore offer a potentially valuable method for refining the range of phenotypes associated with variation in FMR1. This study adopted a broader phenotype approach, focusing on parents who are at increased genetic liability for autism or FXS. Women who were carriers of FMR1 in its premutation state were compared with mothers of individuals with autism, and controls in an attempt to determine whether subtle features of the broad autism phenotype may express at elevated rates among FMR1 premutation carriers.
title: 100 Jahre Helmholtz-Fonds e. V. und 40 Jahre Helmholtz-Preis
title: 100 Jahre Helmholtz-Fonds e. V.
titleType: Subtitle
title: Zur heutigen Bedeutung des Helmholtz-Fonds
titleType: Subtitle
title: Helmholtz-Preis - Für herausragende Arbeiten in der Metrologie
titleType: Subtitle
Creators: name: Göbel, Ernst O.
name: Scharf, Rainer
Publisher: name: Physikalisch-Technische Bundesanstalt (PTB)
Year: 2014

description: PTB-Mitteilungen. Band 123 (2013), Heft 4, Seite 1 - 43. ISSN 0030-834X
Evidence for involvement of GNB1L in autism
Creators: name: Shellenberg, Gerard D.
name: Wijsman, Ellen M.
name: Tsuang, Ming T.
name: Matsushita, Mark
name: Sul, Youngmee
name: Estes, Annette
name: Chen, Ying Zhang
name: Raskind, Wendy H.
name: Eichler, Evan E.
name: Girirajan, Santhosh
name: Rieder, Mark J.
name: Lisowski, Mark
name: Dawson, Geraldine
name: Sun, Elizabeth
name: Nickerson, Deborah A.
name: Tsuang, Debby W.
name: Bernier, Raphael
name: Minshew, Nancy
name: Brkanac, Zoran
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Structural variations in the chromosome 22q11.2 region mediated by nonallelic homologous recombination result in 22q11.2 deletion (del22q11.2) and 22q11.2 duplication (dup22q11.2) syndromes. The majority of del22q11.2 cases have facial and cardiac malformations, immunologic impairments, specific cognitive profile and increased risk for schizophrenia and autism spectrum disorders (ASDs). The phenotype of dup22q11.2 is frequently without physical features but includes the spectrum of neurocognitive abnormalities. Although there is substantial evidence that haploinsufficiency for TBX1 plays a role in the physical features of del22q11.2, it is not known which gene(s) in the critical 1.5 Mb region are responsible for the observed spectrum of behavioral phenotypes. We identified an individual with a balanced translocation 46,XY,t(1;22)(p36.1;q11.2) and a behavioral phenotype characterized by cognitive impairment, autism, and schizophrenia in the absence of congenital malformations. Using somatic cell hybrids and comparative genomic hybridization (CGH) we mapped the chromosome-22 breakpoint within intron 7 of the GNB1L gene. Copy number evaluations and direct DNA sequencing of GNB1L in 271 schizophrenia and 513 autism cases revealed dup22q11.2 in two families with autism and private GNB1L missense variants in conserved residues in three families (P = 0.036). The identified missense variants affect residues in the WD40 repeat domains and are predicted to have deleterious effects on the protein. Prior studies provided evidence that GNB1L may have a role in schizophrenia. Our findings support involvement of GNB1L in ASDs as well. © 2011 Wiley Periodicals, Inc.
Tagungsbericht: „Ressourcen der Rechtskritik: Methodische Reflexion und kritische Praxis“
Creators: name: Ramson, Lasse
Publisher: name: Universität Bremen
Year: 2020
Subjects: subject: Kritische Theorie
subject: 340

description: Ein Tagungsbericht über die Tagung „Ressourcen der Rechtskritik: Methodische Reflexion und kritische Praxis“, die am 26.08.2020 online stattgefunden hat. Es wird berichtet über die Beiträge von Robin Celikates, Ino Augsberg, Tatjana Sheplyakova, Tim Wihl, Sabine Müller-Mall, Alexander Stark, Hannah Birkenkötter, Pauline Weller/Boris Burghardt und Bernard Harcourt.
DEVELOPMENT OF ALLOSTERIC PFKFB3 PHOSPHATASE MODULATORS
Creators: name: MACUT, HELENA
Publisher: name: Universit� degli Studi di Milano
Year: 2019

description: Cardiovascular disease is a severe health problem, especially in the Western world. Its primary cause is atherosclerosis, which is characterized by the arterial wall thickening. Modern therapeutic strategies have restricted efficacy and the mortality still remains high. Current research has supported the idea of targeting dysregulated endothelial cell (EC) metabolism as a novel therapeutic strategy. In the scope of this PhD research work, we aim to further explore the possibilities for an improved treatment of this life threatening disease. EC glycolytic flux is up-regulated during angiogenesis and it is controlled by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3), which is hence an innovative target for atherosclerosis therapy. PFKFB3 is a homodimeric bifunctional enzyme that has a very high kinase to phosphatase activity ratio. Its activity is controlled by the N-terminus autoregulatory domain in the kinase region. The main task of this research work was to explore the alternatives for PFKFB3 modulation apart from potentially problematic ATP kinase inhibition. Virtual screening was performed on the targeted allosteric binding site and here we present the synthesis and biological evaluation of the selected libraries of PFKFB3 allosteric phosphatase modulators deriving from two design strategies. In vitro activity measurement and binding assays were performed on the isolated recombinant enzyme. A phosphatase activity measurement method was developed in-house using LC-MS and the binding assay was performed using microscale thermophoresis. Three peptides (HM 20-22) were found to be able to bind PFKFB3 with a micromolar affinity. HM 21 and 22 were able modulate the PFKFB3 phosphatase activity and interestingly showed the same overall effect on the enzyme kinetics as in the case of a very potent ATP competitive inhibitor. The outcome of the research work presented here suggests that it is possible to use an alternative approach in blocking PFKFB3 activity without inhibiting the kinase. This intriguing discovery could have a significant impact on further research about this important metabolic target and the possibility of its use in atherosclerosis therapy.
Classification of finite metric spaces and combinatorics of convex polytopes
Creators: name: Vershik, A. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Metric Geometry (math.MG)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 52B05, 52B11

description: We describe the canonical correspondence between set of all finite metric spaces and set of special symmetric convex polytopes, and formulate the problem about classification of the metric spaces in terms of combinatorial structure of those polytopes.
description: 5 pp, Ref 5, 2 pictures
Genetic predictors of risk and resilience in psychiatric disorders: A cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia
Creators: name: Robinson, Elise B.
name: Duncan, Laramie E.
name: Smoller, Jordan W.
name: Mcgrath, Lauren M.
name: Lee, Phil H.
name: Gerber, Gloria
name: Perlis, Roy H.
name: Huang, Jie
name: Barnett, Jennifer H.
name: Sklar, Pamela
name: Sullivan, Patrick
name: Cornelis, Marilyn C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Functional impairment is one of the most enduring, intractable consequences of psychiatric disorders and is both familial and heritable. Previous studies have suggested that variation in functional impairment can be independent of symptom severity. Here we report the first genome-wide association study (GWAS) of functional impairment in the context of major mental illness. Participants of European-American descent (N=2,246) were included from three large treatment studies of bipolar disorder (STEP-BD) (N=765), major depressive disorder (STAR*D) (N=1091), and schizophrenia (CATIE) (N=390). At study entry, participants completed the SF-12, a widely-used measure of health-related quality of life. We performed a GWAS and pathway analysis of the mental and physical components of health-related quality of life across diagnosis (~1.6 million single nucleotide polymorphisms), adjusting for psychiatric symptom severity. Psychiatric symptom severity was a significant predictor of functional impairment, but it accounted for less than one-third of the variance across disorders. After controlling for diagnostic category and symptom severity, the strongest evidence of genetic association was between variants in ADAMTS16 and physical functioning (p=5.87 × 10−8). Pathway analysis did not indicate significant enrichment after correction for gene clustering and multiple testing. This study illustrates a phenotypic framework for examining genetic contributions to functional impairment across psychiatric disorders.
Selecting Horndeski theories without apparent symmetries and their black hole solutions
Creators: name: Babichev, Eugeny
name: Charmousis, Christos
name: Hassaine, Mokhtar
name: Lecoeur, Nicolas
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Starting from a generalised Kaluza-Klein action including arbitrary Horndeski potentials, we establish integrability and compatibility conditions that solve the generic field equations for spherical symmetry. The resulting theories can be identified as general Horndeski theories having no apparent symmetries in four dimensions or as effective string theory actions with an IR logarithmic running for the dilaton, higher order corrections and generalised Liouville type potentials. For such actions, we then find black holes with secondary hair parameterized by two coupling constants essentially characterising the theories at hand. One is related to an action which is conformally coupled in five dimensions while the second is related to a Kaluza-Klein reduction of Lovelock theory. We show that the full action can also be interpreted as a sum of conformally coupled actions in differing dimensions. Known solutions are mapped within the general chart of the found theories and novel general black holes are discussed, focusing on their important properties and some of their observational constraints.
Use of Electronic Documentation for Quality Improvement in Hospice
Creators: name: Durham, Danielle
name: Hanson, Laura C.
name: Cagle, John G.
name: Schenck, Anna P.
name: Spence, Carol
name: Rokoske, Franziska S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Little evidence exists on the use of electronic documentation in hospice and its relationship to quality improvement practices. The purposes of this study were to: (1) estimate the prevalence of electronic documentation use in hospice; (2) identify organizational characteristics associated with use of electronic documentation; and (3) determine whether quality measurement practices differed based on documentation format (electronic vs. nonelectronic). Surveys concerning the use of electronic documentation for quality improvement practices and the monitoring of quality-related care and outcomes were collected from 653 hospices. Users of electronic documentation were able to monitor a wider range of quality-related data than users of nonelectronic documentation. Quality components such as advanced care planning, cultural needs, experience during care of the actively dying, and the number/types of care being delivered were more likely to be documented by users of electronic documentation. Use of electronic documentation may help hospices to monitor quality and compliance.
LE 'AZIONI PER IL PUBBLICO INTERESSE' IN CINA
Creators: name: NOVARETTI, SIMONA
Publisher: name: Universit� degli Studi di Milano
Year: 2011

description: There are growing signs of the emergence of a new Chinese civil society which stems from a heightened consciousness of the Chinese people to their rights and displays a greater willingness to face challenges in order to defend such rights by means of litigation. Evidence of such a shift can be detected in the intensification of what has been defined, in Chinese, as gongyi susong (literally: public intrest litigation). Although this kind of litigation constitutes a rather recent development in China, recourse to such a device has seen an exponential growth in recent years and has become one of the fundamental topics of debate and investigation in fields which extend well beyond scholarship and case law. The Chinese definition itself discloses an indebtment to American conceptions of public interest litigation, and a growing number of NGOs, law firms, lawyers (and, at times, individuals) file such cases almost on a daily basis, reminding government authorities of their duties and obligations under the law. This has, in some instances, led to outright confrontation with the regime in the name of public interest. What is meant, concretely, in China, by ?public interest litigation?? What tools can Chinese citizens and their lawyers use to defend the public interest? Moreover, what is the public interest which ?gongyi susong? claims seek to safeguard? The present thesis addresses and provides some insight on the foregoing questions, through the lens of a series of interviews carried out by the author in 2009 with Chinese lawyers based in Beijing.
(100726) Francis Bennett
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
DEVELOP CREATIVITY IN STUDENTS THEORETICAL AND METHODOLOGICAL BASIS
Creators: name: Ismoilova, N.S.
Publisher: name: Zenodo
Year: 2023

description: The article describes the theoretical-methodological foundations of the development of creativity in students, including the level of scientific-theoretical study of the problem, pedagogical ways of developing creativity, criteria of pedagogue's creativity, existing theoretical and practical models of creativity development, and methods of improving the system of developing a creative person.
Correlates of Dietary Intake Among Men Involved in the MAN for Health Study
Creators: name: Ornelas, India
name: Horton, Earl
name: Montano, Jaime
name: Ayala, Guadalupe X.
name: Eng, Eugenia
name: Armstrong-Brown, Janelle
name: Dodds, Janice M.
name: Mebane, Elvira
name: Amell, James W.
name: Rhodes, Scott D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The clustering of diet and other lifestyle behaviors and their psychosocial correlates were examined among 455 Latino and African American men in the U.S. Southeast. Men were recruited by male community health workers and surveys were self-administered in a group format. Latino men were younger, less educated, and more likely to be employed than African American men and reported a lower household income and larger household size. Fruit and vegetable consumption was associated with physical activity (p ≤ .001). A more positive attitude toward health was associated with meeting vegetable dietary guidelines (p ≤ .05) and consuming fast food less frequently (p ≤ .01). Active coping was associated with meeting fruit and vegetable dietary guidelines (p ≤ .01 and p ≤ .001, respectively), and avoidant coping was associated with greater fast-food consumption (p ≤ .001). Latino fast-food consumption was associated with binge drinking (p ≤ .001). This research provides evidence for tailoring dietary intervention for men of color.
(100721) Lancelot John Thorne Beck
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Nematicity, magnetic fluctuation and ferro-spin-orbital ordering in BaFe$_2$As$_2$ family
Creators: name: Sen, Smritijit
name: Ghosh, Haranath
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Through detailed electronic structure simulations we show that the electronic orbital ordering (between d$_{yz}$ and d$_{xz}$ bands) takes place due to local breaking of in-plane symmetry that generates two non-equivalent $a$, $b$ directions in 122 family of Fe-based superconductors. Orbital ordering is strongly anisotropic and the temperature dependence of the corner zone orbital order maps to that of the orthorhombicity parameter. Orbital anisotropy results in two distinct spin density wave nesting wave vectors and causes inter-orbital charge and spin fluctuations. Temperature dependence of the orbital order is proportional to the nematic order and it sets in at a temperature where magnetic fluctuation starts building. Magnetic fluctuations in the orthorhombic phase is characterized through evolution of Stoner factor which reproduces experimentalfindings very accurately. Orbital ordering becomes strongly spin dependent in presence of magnetic interaction. Occupation probabilities of all the Fe-d-orbitals exhibit temperature dependence indicating their possible contribution in orbital fluctuation. This need to be contrasted with the usual definition of nematic order parameter (n$_{d_{xz}}$-n$_{d_{yz}}$). Relationship among orbital fluctuations, magnetic fluctuations and nematicity are established.
description: 22 pages, 8 figures ; http://authors.elsevier.com/a/1Sni33IWkbm~By. Journal of Alloys and Compounds (2016)
Assessing and Promoting Physical Activity in African American Barbershops: Results of the FITStop Pilot Study
Creators: name: Linnan, Laura A.
name: Reiter, Paul L.
name: Duffy, Courtney
name: Viera, Anthony J.
name: Ward, Dianne S.
name: Hales, Derek
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: This study assessed the feasibility of recruiting African American men in barbershops, assessing their physical activity, conducting physical measurements, and gauging their interest in barbershop-based health research. The authors recruited African American shop owners (n = 4), barbers (n = 6), and customers (n = 90) from four barbershops in Raleigh and Durham, North Carolina, during 2009. The participation levels were high among owners (100%), barbers (67%), and customers (81%). In addition to completing a self-administered survey, 57% (51/90) of the customers completed physical measurements. According to self-reported data, 34% (30/88) of the customers met national physical activity recommendations within the last week. Customers expressed moderately high interest in learning more about health at barbershops and joining a barbershop-based physical activity contest. The estimated recruiting cost per customer was $105.92. Barbershops offer an effective setting for recruiting African American men and conducting physical measurements as well as an interesting possible location for conducting future interventions.
Renato Dionisi. L'opera attraverso lo studio critico delle fonti
Creators: name: De Salvo, Salvatore
name: S., Rossi
name: M.
Publisher: name: Universit� degli studi di Trento Dipartimento di Filosofia, Storia e Beni Culturali
Year: 2011

description: Il volume raccoglie gli atti della Giornata di Studi dedicata alla figura e all?opera del compositore e didatta Renato Dionisi, tenutasi all?Universit� di Trento il 19 novembre 2010 nell?ambito delle celebrazioni per il centenario della nascita e il decennale della morte. Il progetto di valorizzazione del prezioso lascito culturale, perseguito attraverso una sistematica indagine critica e musicologica, comprende l?edizione on line del catalogo delle opere di Renato Dionisi: http://musiclab.lett.unitn.it
Energy Dissipation by Metamorphic Micro-Robots in Viscous Fluids
Creators: name: Hogg, Tad
Publisher: name: arXiv
Year: 2015
Subjects: subject: Robotics (cs.RO)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: Microscopic robots could perform tasks with high spatial precision, such as acting on precisely-targeted cells in biological tissues. Some tasks may benefit from robots that change shape, such as elongating to improve chemical gradient sensing or contracting to squeeze through narrow channels. This paper evaluates the energy dissipation for shape-changing (i.e., metamorphic) robots whose size is comparable to bacteria. Unlike larger robots, surface forces dominate the dissipation. Theoretical estimates indicate that the power likely to be available to the robots, as determined by previous studies, is sufficient to change shape fairly rapidly even in highly-viscous biological fluids. Achieving this performance will require significant improvements in manufacturing and material properties compared to current micromachines. Furthermore, optimally varying the speed of shape change only slightly reduces energy use compared to uniform speed, thereby simplifying robot controllers.
description: corrected typos
HPV Vaccine Acceptability in Heterosexual, Gay, and Bisexual Men
Creators: name: Reiter, Paul L.
name: Ng, Terence W.
name: Gilbert, Paul
name: Brewer, Noel T.
name: Smith, Jennifer S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: We know little about men’s beliefs about human papillomavirus (HPV) vaccine and willingness to receive it. In January 2009, the authors recruited 296 heterosexual men and 312 gay and bisexual men from a national panel of U.S. households to complete an online survey about HPV and HPV vaccine. The authors analyzed data using logistic regression, controlling for age, education, number of lifetime sexual partners, and urban residence. More gay and bisexual men than heterosexual men were willing to receive HPV vaccine (73% vs. 37%; adjusted odds ratio = 4.99; 95% confidence interval = 3.36, 7.49). Gay and bisexual men reported greater awareness of HPV vaccine, perceived worry about HPV-related diseases, perceived effectiveness of HPV vaccine, and anticipated regret if they declined vaccination and later developed HPV-related disease compared with heterosexual men (all ps < .05). The lower acceptability and different beliefs among heterosexual men suggest that novel interventions for this group may be needed.