cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Synthesis of Benzylisoquinoline Alkaloids as Antimitotic Agents for Cancer Therapy
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The isoquinoline alkaloids are naturally-occurring small molecules that suppress the proliferation of lung, breast, and leukemia cancer cell lines, including those that express mutant-p53. Their antiproliferative and proapoptosis functions are believed to arise from mechanisms of action that interfere with microtubule networks and p53 proteins. Thus, this proposal seeks to develop novel therapeutic leads to combat cancer. Inspired by the antimitotic function of scoulerine and berberine, we will synthesize structurally-related natural products within this family that have never been subjected to bioevaluation so that a thorough understanding of their antiproliferative effects can be advanced. Computational modeling will be employed to gain insight on substrate-protein interactions. It is our intention to use this knowledge to design and synthesize a series of non-natural analogs with improved potency and investigate structure-activity relationships through cytotoxicity screening and proliferation/viability assays. The goal of these studies is to develop novel lead candidates for cancer therapy.
ELUCIDATING HETEROGENEITY IN THE MICROENVIRONMENT OF COLORECTAL CANCER AT SINGLE-NUCLEUS RESOLUTION
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Metastatic colorectal cancer (mCRC) is common, yet therapies are limited, and the 5-year survival rate is dismal. Bulk gene expression profiling has enabled classification of localized CRC into molecular subtypes predictive of clinical behavior. However, the prognostic value of subtyping in metastatic CRC is less clear. Since it is metastases that kill most patients, the need to characterize mCRC is compelling. Further, many genes associated with poor-prognosis subtypes are expressed by stromal rather than neoplastic elements such as cancer-associated fibroblasts (CAFs). Since cellular diversity within a tumor is poorly captured by bulk transcriptomics, we propose that single-nucleus gene expression analyses of mCRC tumors can identify stromal cell types associated with clinical outcome.

 My group has generated a unique biorepository of cryopreserved hepatic metastases from >200 patients undergoing resection for mCRC and has established the feasibility of single-nucleus RNA sequencing (snRNA-seq) on snap-frozen liver metastases. Preliminary findings support the hypothesis that stromal cell populations, particularly CAFs, comprise a biologically important component of mCRC tumors. While the high cost of snRNA-seq has limited its applicability to large patient studies, our co-investigator at UCSF, Dr. Zev Gartner (Pharmacological Chemistry) has developed a method for multiplexing samples for massively parallel single-nucleus transcriptional analyses, with a marked cost savings.

 We will profile the transcriptional state of tumor and stromal cells in mCRC liver metastases from 50 patients and characterize chemotherapy-induced changes in the stromal and tumor transcriptome by comparing tumors from chemo-naïve and -treated patients. We expect this to reveal insights into the mechanisms of sensitivity or resistance to first line chemotherapy in patients. Since KRAS mutations are strongly associated with poor outcome in mCRC, we will investigate impact of RAS mutations on the potential interplay between cancer cells and stromal cells in mCRC through transcriptomic analysis of patient tumors. Our goal is to elucidate how tumor and stromal cells interact to define the phenotype of mCRC, forming the foundation for an NIH proposal, in which stromal cells will be added to tumor organoids to engineer a more predictive in vitro model of patient-specific drug responses.
Physalis peruviana Linnaeus
Creators: name: Jeanmonod, Daniel
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Solanales
Solanaceae
Physalis
Physalis peruviana

description: Physalis peruviana L.
− Golfe d’Ajaccio, au bas du barrage de l’ancien pénitencier de Coti-Chiavari, dans un fossé ensablé au bord du chemin longeant le petit ruisseau de Formicolosa [41°47’25’’N 8°46’16’’E], plusieurs pieds groupés en un ensemble dense de 1,2 m de long sur 0,8 m de large, 170 m, 1.10.201 0, Paradis, G. & C. Piazza s.n. (Hb. privé Paradis); Santa Lucia di Portivechju au niveau de la D 468 lieu-dit Costa-Baca, terrains exposés sud [41°39’40’’N 9°21’43’’E], 60-100 m, plusieurs plantes sur éboulis rocheux en plein soleil ou en ombre légère, 1.10.201 3, Deleuze, J. observation.
Cette espèce subspontanée n’était connue en Corse qu’en quatre stations (Biguglia, Corte, Rondinara et Porto-Vecchio), et souvent avec un seul pied (voir TISON & DELAGE, Candollea 67: 320, 2012). Contrairement à ce qui est indiqué par ces derniers auteurs, elle est normalement pérenne (comme mentionné dans Fl. Corsica (ed. 2), JEANMONOD & GAMISANS: 696, 2013), mais comme c’est une plante gélive (-1/-2°C), elle se comporte en annuelle qui ne risque donc pas de se multiplier sauf dans des endroits très particuliers sans gel. Les semis naturels se développent en avril-mai et, en l’absence d’eau estivale, la plante meurt souvent mais elle peut aussi survivre et rester en latence comme par exemple dans la station mentionnée ci-dessus sur éboulis rocheux en plein soleil, où une partie des branches sèchent mais la plante repart et peut subsister au moins 3 ans comme certains pieds. Aux pluies automnales, la fructification a alors lieu durant les mois d’hiver à moins que le gel ait fait son effet. C’est pourquoi son invasion ne peut être que très limitée aux endroits sans gel ou près de ruisseaux. Cette plante est cultivée depuis des dizaines d’années dans les jardins du Cap et en Castagniccia sans poser de problème d’invasion. Dans la 1ère station, la plante atteint 1,2 m de hauteur; ses tiges aériennes, un peu sarmenteuses, sont très ramifiées et des rameaux, insérés à la base, juste au-dessus du sol, sont plagiotropes et s’enracinent à une vingtaine de cm, ce qui correspond à un marcottage. Ces nouvelles stations montrent qu’elle mérite un statut R (rare) plutôt que RR (très rare).
description: Published as part of Jeanmonod, Daniel, 2015, Notes à la flore de Corse, XXV, pp. 109-140 in Candollea 70 (1) on page 138, DOI: 10.15553/c2015v701a10, http://zenodo.org/record/5720895
Brachycarcharias Cappetta & Nolf 2005
Creators: name: Ebersole, Jun A.
name: Cicimurri, David J.
name: Stringer, Gary L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Elasmobranchii
Lamniformes
Odontaspididae
Brachycarcharias

description: Genus Brachycarcharias Cappetta & Nolf, 2005
Type species
Otodus vincenti Winkler, 1876, Eocene, Belgium.
description: Published as part of Ebersole, Jun A., Cicimurri, David J. & Stringer, Gary L., 2019, Taxonomy and biostratigraphy of the elasmobranchs and bony fishes (Chondrichthyes and Osteichthyes) of the lower-to-middle Eocene (Ypresian to Bartonian) Claiborne Group in Alabama, USA, including an analysis of otoliths, pp. 1-274 in European Journal of Taxonomy 585 on page 37, DOI: 10.5852/ejt.2019.585, http://zenodo.org/record/3660259
The Brief Social Media Fatigue Scale (BSMFS): A New Short Version Through Exploratory Structural Equation Modeling and Associations with Trait Anxiety, Fear of Missing Out, Boredom Proneness, and Problematic Use
Creators: name: Faraci, Palmira
name: Nasonte, Giuliana
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Cell Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy
subject: Mental Health

description: This study examines the psychological impact of social media use through the psychometric validation of the Social Media Fatigue Scale (SMFS). Using a sample of 329 Italian social media users, the dimensionality of the scale was assessed using Exploratory Factor Analysis, subsequently corroborated by comparing Confirmatory Factor Analysis and Exploratory Structural Equation Modeling (ESEM). The refined brief scale comprised three factors within the ESEM framework (RMSEA = .046, p = .54; CFI = .984; TLI = .967, and SRMR = .033) and showed good reliability (ωF1=.75; ωF2=.89; ωF3=.73). The research further explores the associations between social media fatigue (SMF) and trait anxiety through path analyses, examining the mediating role of the fear of missing out (FoMO) and the influence of boredom proneness on SMF, with problematic social media use serving as a moderator. The results, supporting the hypothesized roles of FoMO and problematic social media use, are discussed in relation to the relevant literature.
Solanum bonariense Linnaeus
Creators: name: Jeanmonod, Daniel
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Solanales
Solanaceae
Solanum
Solanum bonariense

description: Solanum bonariense L.
− Ajaccio, quartier Pietralba, de nombreux pieds dans un terrain vague voué à la construction en bordure de la route du Mont Thabor ainsi que dans un vallon avec des oliviers au SE de cette route, entre Pietralba et Saint Joseph, 11.11.201 2, Paradis, G. & E. Texier s.n. (Hb privé Paradis, photos).
Cette espèce subspontanée, originaire d’Amérique du Sud et très rare en Corse, avait été observée à Ajaccio au quartier du Casone en 1939 par Malcuit, mais ce botaniste ne l’avait pas retrouvée en 1945 (in BRIQUET & LITARDIERE, Prodr. Fl. Corse 3/2: 251, 1955) et depuis, elle ne semble pas avoir été signalée à Ajaccio ou dans ses environs. Les deux localisations du quartier Pietralba sont proches l’une de l’autre. Les nombreux individus se sont vraisemblablement échappés à partir d’une introduction comme espèce ornementale dans un jardin. Ailleurs à Ajaccio, S. bonariense a été plantée en haie, près du lotissement «les Aloès». Ailleurs en Corse, elle a été signalée à Bastia sur la rive gauche du Fango et entre Lupino et l’Arenella (CONRAD, Etudes Corses, n.s. 27-28: 64-68, 1960) ainsi qu’à l’île Rousse (ALPHAND, Candollea 44: 623, 1989).
description: Published as part of Jeanmonod, Daniel, 2015, Notes à la flore de Corse, XXV, pp. 109-140 in Candollea 70 (1) on page 139, DOI: 10.15553/c2015v701a10, http://zenodo.org/record/5720895
Solanum mauritianum Scop.
Creators: name: Jeanmonod, Daniel
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Solanales
Solanaceae
Solanum
Solanum mauritianum

description: Solanum mauritianum Scop.
− Talasani: route de Vallelongue près de son intersection avec la RN198 (42°25’13.6’’N 9°31’42.0’’E), bord d’une ptéridaie mésohygrophile dégradée envahie par Convolvulus sepium L. et Rubus ulmifolius Schott, 4 touffes dispersées sur 30 m environ, 17.7.201 4, Tison, J.-M. s.n. (Hb. privé).
Xénophyte nouvelle pour la Corse, d’origine néotropicale. Le «bringellier marron» est connu depuis longtemps comme espèce invasive préoccupante en climat tropical (données compilées par exemple sur la Global Invasive Species Database: http://www.issg.org/database/welcome/). Probablement à la faveur des changements climatiques, il fait aujourd’hui ses premiers pas en Europe en commençant par les régions les plus chaudes et les plus humides: Açores (SILVA ex archives EPPO: https://www.eppo.int/), Madère et Tenerife (F. Verloove comm. pers.), puis Portugal (DOMINGUES DE ALMEIDA, Anales Soc. Bot. Madrid 57: 422, 2000). En France, l’espèce a été citée comme invasive potentielle sans précisions par ABOUCAYA (Biocosme Mésogéen 15: 169-174, 1998) suite à une observation dans une propriété privée de Saint-Jean-Cap-Ferrat (AlpesMaritimes) où elle était plantée et avait tendance à proliférer (G. Alziar comm. pers.), mais on ne peut pas la considérer comme autonome dans ce cas, le désherbage et surtout l’arrosage favorisant largement son expansion. La population corse semble en revanche indépendante; elle comprenait en juillet 2014 un individu fleuri et fructifié dépassant déjà 2 m; les trois autres, encore stériles et hauts de 1 à 1,5 m, étaient très probablement issus de semis de la plante adulte. Nous n’avons pas vu le bringellier dans les quelques jardins environnants et son origine reste à préciser; c’est une plante ornithochore, facilement dispersée à longue distance. Tout comme Sesbania punicea (Cav.) Benth., il est gélif et quelque peu hygrophile et ne peut donc se maintenir en Corse que dans les zones humides du littoral, mais il constitue une menace potentielle pour ces biotopes. Selon J. Deleuze (in litt.), cette plante aurait été introduite dans les années 85/90 de la Réunion dans la région de San Nicolao où elle y a trouvé un climat favorable à sa propagation. Son éradication dans les lieux frais semble difficile car, comme il est dit, l’ornithochorie facilite sa dispersion et sa fructification est continuelle. Un plan d’éradication dans le lieu-dit Leccie-Bordéo avait été tenté dans les années 90/95 sans grand succès. Son éradication a aussi été tentée dans la propriété privée de Saint-Jean-Cap-Ferrat toujours sans succès jusqu’à cette année et quelques pieds apparaissent çà et là jusqu’à Menton.
description: Published as part of Jeanmonod, Daniel, 2015, Notes à la flore de Corse, XXV, pp. 109-140 in Candollea 70 (1) on page 139, DOI: 10.15553/c2015v701a10, http://zenodo.org/record/5720895
Role of a novel RNA endonuclease EndoU in squamous cell carcinomas
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Squamous cell carcinomas (SCCs) are the most common solid tumors, imposing an enormous mortality burden worldwide. This group includes lung, esophagus, oral cavity, skin, cervical and vaginal tumor types. All such carcinomas originate from the unchecked proliferation of stratified epithelial cells, and share common mechanisms of development and progression. We have identified the EndoU gene to be implicated in SCC as a novel potential tumor suppressor. EndoU is strongly downregulated in cervical, esophageal and oral squamous carcinomas, and its expression correlates with favorable prognosis in the squamous-epithelial head and neck cancers, as well as colorectal tumors, underscoring the significance of this factor in important developmental and disease processes. These observations are consistent with a known role for EndoU in promoting cell death during B cell development; however, its function in SCCs is entirely unknown. The EndoU protein is an RNA endonuclease that may post-transcriptionally regulate gene expression programs relevant to proliferation and cell death. Cervical cancer provides an attractive system to investigate the role of EndoU because of its high expression in the cervix lining, strong negative association with tumor development, and the availability of new transgenic mouse models. In this proposal, we aim to determine the tumor-suppressive role of EndoU in cervical cancer using existing mouse models for EndoU KO and cervical cancer establishment, as well as and cell line models to investigate the expression and contribution of EndoU to cell proliferation and death. Successful completion of this proposal is very likely to shed light on the broader role of EndoU in other squamous cell carcinomas. Specifically, the results would support the investigation of EndoU in esophageal cancer (where robust transgenic mouse models are not available), as well as in oral cavity, lung, and vaginal squamous cell carcinomas. In addition, despite the absence of stratified epithelia in the colon, the strong prognostic power of EndoU in colorectal cancers may prompt its investigation in this prevalent cancer type.
Antileukemic organoarsenicals as safe and effective alternatives to arsenic trioxide
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Arsenic trioxide (ATO) is an FDA-approved frontline therapy for acute promyelocytic leukemia (APL). Past mechanistic studies have shown that ATO functions by crosslinking aberrant PML-RARα fusion proteins that are characteristic of APL. The activity of these fusion proteins prevents the differentiation of the mutant promyelocytes, which ultimately leads to the disease phenotype. As(III) centers derived from ATO crosslink the proteins through cysteine thiolates, leading to protein aggregation and promyelocyte differentiation. Unfortunately, however, the As(III) released by ATO indiscriminately binds to cysteine thiolates throughout the cell and the organism at large, which contributes to significant off-target toxicity. The proposed research project involves the design, synthesis, and testing of arylarsonic acids, which have the general formula RAsO(OH)2. Organoarsenic species are less toxic than inorganic arsenic compounds, like ATO, and the structure of the R group can be systematically tuned to increase cell uptake and specificity for binding to PML-RARα. Moreover, arsonic acids feature arsenic in the less reactive and less toxic 5+ oxidation state, as opposed to the 3+ state found in ATO. These prodrugs can then be reduced in the intracellular environment to achieve the reactive 3+ oxidation state. Our laboratory has experience in the synthesis, characterization, and testing of medicinal inorganic compounds, but the proposed project is at the fundamental conception stage and funds are requested to cover the costs of chemicals, cell culture supplies, instrument recharge, and trainees. This funding would allow us to generate the preliminary results needed prepare a competitive application for a major federal operating grant.
MEDICAL AND PERFORMANCE TRENDS IN REPEAT IRONMAN-DISTANCE TRIATHLON COMPETITORS AT THE IRONMAN WORLD TRIATHLON CHAMPIONSHIPS
Creators: name: Cho, Stephanie P
Publisher: name: Washington State University
Year: 2022
Subjects: Ironman
Triathlon

description: Ironman-distance triathlon events are rigorous three-sport ultra-endurance competitions and often result in various adverse medical incidents among competitors. The overall purpose this thesis is to examine medical and performance trends for ironman-distance triathlon competitors over three decades. Standardized data sheets developed by race medical personnel were completed by registered nurses and physicians upon athlete check-in to the medical tent at the event between the years of 1989-2019. Medical trends were investigated for a repeat competitor population and competitors (n=427) were included for analysis within the current investigation if admitted to the tent for at least three competitions within a fifteen-year span. The performance trends investigation included all competitors (n=9446) that received medical attention at the Ironman World Championships from 1989-2019. For medical trends among repeat competitors, significant associations were found between several adverse medical incidents for competitors’ first visit and for all 3+ year competitor visits. Additionally, repeat athletes experiencing hyponatremia, nausea, and muscle cramps during their first year had a significantly higher risk of returning with the same medical problem in subsequent years. Contrarily, participants that experienced vomiting during their initial visit were less likely to return for the same problem in subsequent years. For performance trends, significant differences were found between the category of an athletes’ primary medical issue and finisher status. Athletes that experienced GI distress, dehydration, hyponatremia, and dizziness as a primary issue had significantly lower odds of finishing the race when compared to those with primary medical issues in other categories. Furthermore, we found that seeking medical attention for hyponatremia significantly decreased performance for the total sample, males, and females as well as the 18 and 30-49 age groups when compared to non-hyponatremic athletes. However, seeking medical attention for muscle cramps significantly increased performance for the total sample, females and the 30-49 age group.
Intron Retention in Nutrient Response and Cellular Quiescence
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: There are a number of well-characterized changes in cell behavior that are hallmarks of cancer. These include changes in cellular metabolism and bypass of signals that usually suppress cell growth. An important step in understanding cancer is understanding the molecular basis of these events.

 In order to address this challenge, we are leveraging the model eukaryote Saccharomyces cerevisiae as an experimental system. With its streamlined genome and powerful molecular genetic tools, yeast cells lend themselves well to detailed molecular analyses. Not surprisingly, there is a long history of cancer-relevant molecular mechanisms that have been elucidated from yeast studies.

 In yeast, as with other eukaryotic organisms, more core crucial processes are regulated by messenger RNA splicing, the removal of non-coding sequences, introns, from protein coding genes. Intron removal is a critical step in producing an RNA that is a viable substrate for protein synthesis. Mis-regulation of splicing is a significant contributor to tumorigenesis. However, under a variety of conditions—both in normally functioning cells and in disease states, introns are “retained.” The fate and function of these retained introns are poorly understood.

 We have recently found that the ability of yeast cells to adjust their metabolism in response to glucose availability is dependent upon regulation of intron retention. In fact, both glucose metabolism and cellular quiescence are regulated by intron retention. Surprisingly, some intron-retained transcripts contain signals within the intron that allow the production of a functional protein product. The following aims explore the nature of these signals and their effect on cell growth and glucose metabolism.

 Aim 1: Determine what pre-mRNA features affect intron retention in response to glucose availability.
 Aim 2: Determine what intronic features contribute to recognition of intronic translation signals.
 Aim 3: Characterize proteins that facilitate recognition of intronic translation signals.

 In light of the abundance of introns, the prevalence of their retention in mammalian cells, and the conservation of proteins involved in both splicing and translation, these studies will address fundamental mechanisms of gene expression that affect cellular function and dysfunction, including important hallmarks of cancer.
A new look at disk winds and external photoevaporation in the σ-Orionis cluster appendix
Creators: name: Maucó, Karina
Publisher: name: Zenodo
Year: 2024
Subjects: subject: Stellar astronomy
subject: Planetary sciences

description: Appendix for the A&A accepted paper entitled "A new look at disk winds and external photoevaporation in the σ-Orionis cluster" by Maucó et al. 2024.
Molecular basis of force-sensing by keratin network
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Physical integrity of epithelial tissue is established and maintained by the cytoskeletal network that integrates neighboring cells and extracellular matrix. In particular, keratin intermediate filament proteins expressed in all epithelial tissues are thought to be responsible for structural integrity of epithelial tissues and recently emerged as a driver of collective cell migration. Yet, unlike actin, understanding of keratin mechano-biology is still very limited. In this proposal, we demonstrate that keratin network responds to externally applied physical forces by recruiting cten, a protein known to act as both a tumor suppressor and promotor in a tissue specific manner. We hypothesize that force-dependent interactions surrounding cten are responsible for opposing functions of cten in various cancer cells. Therefore, our goal is to determine the differences in force-dependent protein interactome surrounding cten in various cancer cell lines. To identify force-sensitive protein-protein interactions surrounding cten, the protein interactions are detected by in situ proximal biotin labeling while cells are being physically stimulated. By fusing cten to a promiscuous biotin ligase, any proximal proteins are biotinylated. The biotinylated proteins are identified by proteomic screening using mass spectrometry analysis and the degree of biotinylation in the presence or absence of external force will be used to classify force-sensitive protein interactions. Newly identified force-sensitive protein candidates will be tested to verify their force-dependent co-localization with cten and keratin filaments in various cancer cells. This approach will reveal the comprehensive list of cten associated proteins in the presence or absence of external forces in cancer cell lines and may explain opposing functions of cten in various cancers.
Vitis rupestris Scheele
Creators: name: Jeanmonod, Daniel
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Vitales
Vitaceae
Vitis
Vitis rupestris

description: Vitis rupestris Scheele
− Belgodère: maquis dégradés le long de la RN197 à l’ouest de Lozari, 3.9.201 2, Tison, J.-M. s.n. (Hb. privé); Santa-Maria-Poggio: bord de la RN198 au sud de Moriani-plage près du restaurant Cinderella, 3.9.201 2, Tison, J.-M. s.n. (Hb. privé); Canale-diVerde: bord d’une vigne abandonnée sur le CD17 à l’est de l’embranchement du CD42, 3.9.201 2, Tison, J.-M. s.n. (Hb. privé); Porto-Vecchio: murets bordant la RN198 près du panneau d’entrée nord de la ville, 1.9.201 2, Tison, J.-M. s.n. (Hb. privé); Bonifacio: murets bordant la RN198 en lisière de chênaie verte au sud du Cavallo-Morto, 2.9.201 2, Tison, J.-M. s.n. (Hb. privé).
Ces pointages s’ajoutent à ceux de Bastia, de Lupino, de Ponte-Leccia, de Saint-Florent et de l’estuaire de la Solenzara cités par LAMBINON (Candollea 61: 93-134, 2006). Comme pour l’hybride V. riparia × V. rupestris, les stations sont en fait beaucoup plus nombreuses que ces quelques récoltes, mais ici elles restent généralement ponctuelles (J.-M. Tison obs. pers., août-septembre 2012). Contrairement aux V. rupestris du Midi, qui appartiennent essentiellement au clone mâle ‘du Lot’, ceux de Corse comprennent des individus femelles capables de fructifier. Pourtant, tout comme dans le Midi, la plante ne semble pas réellement naturalisée: il s’agit d’individus isolés ou peu nombreux dans des biotopes à faible biodiversité, probablement des porte-greffes survivant sur l’emplacement d’anciennes vignes aujourd’hui envahies par le maquis. Ces nouvelles stations la font passer du statut de rare (R) à celui de «peu fréquent» (PF).
description: Published as part of Jeanmonod, Daniel, 2015, Notes à la flore de Corse, XXV, pp. 109-140 in Candollea 70 (1) on page 140, DOI: 10.15553/c2015v701a10, http://zenodo.org/record/5720895
title: Cinderella: Disney’s foremost plastic and postfeminine icon
Creators: name: Hurley, Melanie P.
Publisher: name: Memorial University of Newfoundland
publisherIdentifier: https://ror.org/04haebc03
publisherIdentifierScheme: ROR
Year: 2025

description: Cinderella: Disney’s Foremost Plastic and Postfeminine Icon provides a feminist analysis of Disney’s Cinderella, one of the company’s thirteen official princesses. It understands Cinderella as an icon, plastic because she is adaptable to many contexts and because her significations are extremely flexible, and postfeminine because these significations are contradictory. The dissertation uses postfeminist critique and aesthetic theories of glamour to analyze how this icon has gained her many significations through her presence in a variety of historical and media contexts. To get a multifaceted understanding of the icon, it closely examines Disney’s animated Cinderella, originally released in 1950, and several Disney Princess picture-book treasuries, sticker books, and calendars. Additionally, to understand how the cultural contexts of these Disney products influence the icon’s significations, it uses a series of intertexts, such as the post-war films Sabrina, Gigi, Breakfast at Tiffany’s, and My Fair Lady; Britney Spears’s early songs and music videos; Home Box Office’s sitcom Sex and the City; and multiple products from Mattel’s Barbie brand. It argues that Cinderella’s significations include women’s discontentment with domestic labour and female empowerment through performative labour; class struggle and socioeconomic aspiration; romantic love and its interrogation; cultural pressure for women to embody conventional standards of attractiveness; the culture’s objectification of women; rabid consumerism; and stereotypical female passivity and helplessness. It concludes that Cinderella has feminist potential, but that Disney—especially the Disney Princess brand—limits that potential and instead maintains rigid definitions of girlhood and womanhood, using this icon to foster little girls’ interest in dress, personal grooming, and consumer goods, and to prompt their desire for social status and material wealth.
Label free, high throughout detection and separation of individual breast cancer stem cells
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cancer stem cells (CSCs) are a rare cellular subset within a tumor (1-5% but in some tumors only up to ~0.01% of the total tissue) that are believed to be responsible for the metastatic progression of cancer, as well as resistance to chemotherapy and radiation therapies, and disease relapse. As such, the successful isolation of viable CSCs with minimal perturbation and manipulation, would enable further understanding of CSC biology, which is necessary for the development of novel therapeutics directly targeting this rare subset of aggressive cells. This is especially relevant to breast cancer where 100% of mortality is due to metastasis. The goal of the proposal is to design a microfluidic platform capable of label-free isolation of viable CSCs breast cancer cells from blood and tissue.

 CSCs will be separated based on their unique mechanical properties. Identifying the cells using physical and mechanical properties rather than chemical markers makes the platform independent of an a priori knowledge of cells’ surface characteristics, which is often unknown. The microfluidic channel we designed contains a cavity flanked by two narrower regions; at all positions along the channel, the channel width is larger than or comparable to the cells’ size. The inhomogeneous pressure gradients and shear stress in such a channel cause multiple deformations of the cell in both directions. The new platform will provide characterization of individual cells and allow finding one-to-one correspondence between a given cell’s mechanical properties and the same cell’s biological function. Hundreds of cells will be analyzed per second, and 5 mL of cells suspension will be analyzed within 15 minutes.

 In Aim 1, the cells (MCF-7 and MDA-MB-231) will be characterized by combined optical and electrical signals analyzed by advanced machine learning approaches. Machine learning algorithms will be applied to find direct correspondence between the optical and electric signals, enabling one to characterize cells’ deformation based on electrical recordings only.
 In Aim 2 we will develop a platform to isolate individual CSCs that can be subjected to further biochemical analysis.

 This work will lay the foundation toward the understanding of CSCs, the cancer stem cell model, and the development of potential CSC-specific drug therapies for the treatment of metastatic cancer.
In-cylinder turbulence and cycle variations in an optical compression-ignition engine
Creators: name: Knight, Tristan
Publisher: name: Loughborough University
Year: 2025
Subjects: classificationCode: 401799
subject: Mechanical engineering not elsewhere classified

description: Increasingly stringent emissions regulations have created the need for ever increasing improvements to be made to the reduction of compression ignition engine emissions. Understanding and predicting the possible in-cylinder flow structures that occur within compression-ignition (CI) engines is vital if further optimisation of combustion systems is to be achieved. To enable this prediction, fully validated computational models of the complex in-cylinder flows from intake through to the combustion process are needed. However, generating, analysing and interpreting experimental data to achieve this validation remains a complex challenge due to the variability that occurs from cycle to cycle.The flow-velocity data gathered in this thesis over a vast range of spatial locations and test condition, obtained from a single-cylinder CI engine with optical access using high-speed PIV, demonstrates that significantly different structures are generated over different cycles. This results in the mean flow failing to adequately reflect the typical flow produced in-cylinder. Additionally, this high level of variability is shown by the work to impact the assessment of turbulence throughout the cycle, influencing the values often used to validate mathematical models. The analysis approach presented uses proper orthogonal decomposition (POD) and spatial filtering to interpret the progression of the flow structures and energy throughout compression, giving an understanding of the actual flow structures that are most likely to be produced in the engine. This analysis is applied to flows produced from two different cylinder heads; a high swirl head and a low swirl head. It was shown that the strongly organised flow induced from the high swirl head decays at a lower rate resulting in the flow energy dissipating to turbulence at the end of compression.The work goes on to investigate the high pressure fuel spray structure in the single cylinder engine using high speed images to determine the information needed for model validation. This data provided quantitative validation to CFD results on the levels of variations which could occur. Finally, the combustion flame is captured to quantify the variations in the structure and timing of the combustion event. This data showed that the higher engine speed experiences less variations in the combustion, which can be related to the trend of higher turbulence and less variations in the air flow for higher speeds.The differences in air flow, fuel spray from a mean condition have been shown to result in changes in the combustion which will influence the production of emissions. Therefore, it is important that the variations quantified in this thesis are considered in simulations.
Hypotodus Jaekel 1895
Creators: name: Ebersole, Jun A.
name: Cicimurri, David J.
name: Stringer, Gary L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Elasmobranchii
Lamniformes
Odontaspididae
Hypotodus

description: Genus Hypotodus Jaekel, 1895
Type species
Lamna verticalis Agassiz, 1843, Ypresian, United Kingdom.
description: Published as part of Ebersole, Jun A., Cicimurri, David J. & Stringer, Gary L., 2019, Taxonomy and biostratigraphy of the elasmobranchs and bony fishes (Chondrichthyes and Osteichthyes) of the lower-to-middle Eocene (Ypresian to Bartonian) Claiborne Group in Alabama, USA, including an analysis of otoliths, pp. 1-274 in European Journal of Taxonomy 585 on page 45, DOI: 10.5852/ejt.2019.585, http://zenodo.org/record/3660259
Vitis vinifera subsp. vinifera
Creators: name: Jeanmonod, Daniel
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Vitales
Vitaceae
Vitis
Vitis vinifera
Vitis vinifera subsp. vinifera

description: Vitis vinifera subsp. vinifera
− Santa-Lucia-di-Moriani: lambeau de ripisylve rudéralisée sur la RN198 en face de l’embranchement du CD109, 3.9.201 2, Tison, J.-M. s.n. (Hb. privé); SantaMaria-Poggio: bord de la RN198 au sud de Morianiplage près du restaurant Cinderella, 3.9.201 2, Tison, J.-M. s.n. (Hb. privé); Porto-Vecchio: broussailles le long de la route littorale près de Marina di Fiori, 1.9.201 2, Tison, J.-M. s.n. (Hb. privé); Bonifacio: murets bordant la RN198 en lisière de chênaie verte au sud du Cavallo-Morto, 2.9.201 2, Tison, J.-M. s.n. (Hb. privé).
Les récoltes citées correspondent à des plantes trouvées hors cultures, distinctes des nombreuses variations de la subsp. sylvestris par leurs feuilles rapidement glabrescentes à la face inférieure et/ou à sinus basal fermé, souvent bien plus grandes sur l’ensemble de la plante, et, lorsqu’elles sont fructifiées, par les pépins à bec long. Elles sont par ailleurs très différentes entre elles, mais cette variabilité reste compatible avec celle connue chez la subsp. vinifera (cf. GALET, Précis d’ampélographie pratique, 6e éd., Paul Déhan, Montpellier, 1991) et il n’y a pas de marqueurs évidents d’influence d’autres espèces. Ces individus semblent dans la même situation de survie que V. rupestris, à ceci près que leurs longues tiges leur permettent de coloniser jusqu’à plusieurs ares; les marqueurs moléculaires montrent que V. vinifera subsp. vinifera ne se naturalise pas vraiment en Sardaigne (ZECCA et al., Plant Biol. 2009: 2-6, 2009) et on peut présumer qu’il en va de même en Corse.
description: Published as part of Jeanmonod, Daniel, 2015, Notes à la flore de Corse, XXV, pp. 109-140 in Candollea 70 (1) on page 140, DOI: 10.15553/c2015v701a10, http://zenodo.org/record/5720895
Histamine H1 (HRH1): A novel therapeutic target for pancreatic ductal adenocarcinoma?
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: In 2020, it is estimated that ~57,000 people will be diagnosed (and ~47,000 will die) with pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer. PDAC has a 5-year survival of ~9%. Within the next few years PDAC is predicted to be the second leading cause of cancer death. Progress in the treatment of PDAC has thus lagged behind that of many other cancers. My laboratory has an unconventional idea to address this important unmet, medical need. We have asked: Might it be possible to target certain cell surface binding sites, termed receptors, in particular G-protein-coupled receptors (GPCRs, the largest class of targets for approved drugs) by re-purposing FDA-approved GPCR-targeted drugs to aid in the treatment of PDAC?. This project will test whether a particular GPCR, one that binds histamine (known as HRH1), which we have discovered is highly expressed in PDAC, influences PDAC cell function and if its actions can be blocked by FDA-approved HRH1 inhibitors (antihistamines). If so, such antihistamines could potentially be re-purposed as an effective (and likely safe) way to treat PDAC patients.

 Our preliminary studies, using 1) analyses of data for PDAC tumors in The Cancer Genome Atlas (TCGA) and for normal human pancreas in another database and 2) studies with human PDAC cell lines and PDAC cells have identified GPCRs with much higher expression in PDAC. HRH1, among the highest such GPCRs, has many FDA-approved inhibitors (antihistamines, typically used to treat allergic conditions). We hypothesize that HRH1 antihistamines may be candidates for drug re-purposing to treat PDAC. Our Specific Aims will ask: Aim 1) Does histamine, which activates HRH1, alter the function of human and mouse PDAC cells and if so, do FDA-approved antihistamines block such effects? Aim 2) Do FDA-approved HRH1 antihistamines improve the action of agents approved for the treatment of PDAC. These latter studies will test whether FDA-approved antihistamines will enhance the killing of PDAC cells by drugs currently approved and used to treat patients with PDAC. Success in the proposed studies could help set the stage for the rapid initiation of clinical trials with one or more antihistamines in combination therapy as a new approach for the treatment of PDAC and that might improve its currently dismal outcome for PDAC patients.
title: OUTCOMES FOLLOWING DROPLET IMPACT ON A HYDROPHILIC SUBSTRATE
title: SPREADING, JETTING, AND PARTIAL REBOUND
titleType: Subtitle
Creators: name: Asai, Brooklyn
Publisher: name: Washington State University
Year: 2022
Subjects: jetting
maximum spreading
micropatterned surface
multiphase flows
partial rebound
Microfluidics

description: Droplet impact on a solid surface, while ubiquitous, still has many facets to be explored. One of these is the influence of surface characteristics, which we have analyzed through the examination of a novel substrate that is both hydrophilic and microstructured with arrays of pillars. The ability to predict the outcomes following droplet impact such as maximum spreading, jetting, breakup, and partial rebound are crucial in the practical applications of this surface or similar instances. Impacts and the events thereafter were studied for this substrate by impinging water-glycerol solutions of varying viscosity and release height. From our work we have found that the maximum spreading factor, βmax = Dmax/Di, is largely unaffected by the consideration of viscous effects due to the micropillars. Spreading of the droplet can therefore be characterized by a simple scaling of βmax ~ We1/4 found by energy conservations methods. For jetting, we have found that surface wettability and the velocity profile across the jet greatly affect the evolution of the jet dimensions over time, with the jet tip radius and height straying from the typical scaling factor of 2/3 and maintaining average values of 1/5 and 1, respectively. Analyzing partial rebound for our substrate, we have found that this outcome exhibits a near constant volume ratio when comparing the rebounded portion to the original droplet. We find evidence this is likely due to the maximum retraction height before breakup, which is at least two times greater than the capillary length of the fluid. Partial rebound is also found to possess a threshold energy at maximum retraction of 0.5 µW, above which partial rebound is the most likely outcome. For all outcomes, we derive a scaling that infers breakup time is only dependent upon impact conditions, such as impact velocity and fluid properties, and is unrelated to the outcome of the droplet itself. Utilizing these latest outcome characteristics, we are able to further parameterize impact on hydrophilic and micropillared substrates and expand our understanding of the underlying dynamics of spreading, jetting, and partial rebound for this surface.
Leveraging the Human Gut Microbiome to Predict Efficacy of Tamoxifen in Breast Cancer Treatment
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Despite tamoxifen being one of the most commonly prescribed drugs used to prevent cancer from recurring in breast cancer patients, only 50% of patients are effectively treated with this drug. Accurate prediction of which patients will receive the beneficial effects of tamoxifen is not currently possible. The key to unlocking this mystery may be found in the human gut microbiome, which is composed of trillions of bacteria that reside in the gastrointestinal tract.

 Tamoxifen, in addition to being a powerful anti-cancer drug, is also a potent antibiotic that can kill beneficial bacteria in the gut microbiome. Breast cancer patients are treated with tamoxifen for 5–10 years, so injury to the gut microbiome may be severe and long-lasting. As the composition of bacteria in the gut microbiome is linked to numerous diseases, ranging from Parkinson’s disease to breast cancer, clarifying the impact of tamoxifen on the gut microbiome is critical for understanding this treatment’s impact on the overall health of patients. Towards this end, we will perform the first investigation of how communities of gut bacteria may be changed by tamoxifen.

 When bacteria are exposed to antibiotics, a common means of avoiding death is breaking down the drug. In the case of tamoxifen, this would likely prevent the drug from being effective at treating breast cancer. If a breast cancer patient were to harbor tamoxifen-degrading gut bacteria, tamoxifen may not treat their cancer. Because gut microbiome composition differs significantly between people, variable presence of tamoxifen-degrading bacteria in patients’ gut microbiomes may explain why some patients do not receive the beneficial effects of tamoxifen. We will perform the first in-depth investigation to identify how gut bacteria resist being killed by tamoxifen, whether tamoxifen is inactivated in this process, and what chemical features of the drug lead to its antibiotic effects.

 The research we propose is significant because it is expected to show that the gut microbiome is a missing key to accurately predicting which patients will receive the beneficial effects of tamoxifen. Ultimately, the results of this research may provide new opportunities to achieve personalized and more effective treatment of breast cancer by accounting for the uniqueness of each patient’s gut microbiome.
Dysoxylum Blume ex Raspail 1827
Creators: name: Holzmeyer, Laura
name: Hauenschild, Frank
name: Mabberley, David J.
name: Muellner-Riehl, Alexandra N.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Sapindales
Meliaceae
Dysoxylum

description: * Dysoxylum Blume ex Raspail in Bull. Sci. Nat. Géol. 11: 68. 1827
≡ Dysoxylum sect. Cyrtochiton Miq. in Ann. Mus. Bot. Lugduno-Batavi 4: 9, 23. 1868 – Type (designated here for Dysoxylum by D.J. Mabberley): Dysoxylum macrocarpum (Spreng.) Blume ex G.Don.
– “ Dysoxylum Blume”, Bijdr. Fl. Ned. Ind.: 172. 1825, nom. non rite publ. (sine descr.), p.p.
See Mabberley (1995b: 116) for further synonymy.
Blume’ s (1825) “ Dysoxylum ” species and his other species lately referred to Dysoxylum (see Mabberley, 1995b, 2007, 2013a,b for further synonymy, full descriptions, typifications, distributions, uses and further information) can now be assigned as follows:
description: Published as part of Holzmeyer, Laura, Hauenschild, Frank, Mabberley, David J. & Muellner-Riehl, Alexandra N., 2021, Confirmed polyphyly, generic recircumscription and typification of Dysoxylum (Meliaceae), with revised disposition of currently accepted species, pp. 1248-1272 in TAXON 70 (6) on page 1257, DOI: 10.1002/tax.12591, http://zenodo.org/record/14047415