title: ÐÐ½Ð°Ð»Ð¸Ð· Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð½ÐµÐ¹ÑÐ¾Ð½Ð¾Ð² Ð´Ð¾ÑÑÐ°Ð»ÑÐ½Ð¾Ð³Ð¾ Ð³Ð¸Ð¿Ð¿Ð¾ÐºÐ°Ð¼Ð¿Ð° Ð²Ð¾ Ð²ÑÐµÐ¼Ñ Ð¿Ð¾Ð²ÐµÐ´ÐµÐ½ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐµÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð¼ÐµÑÐ¾Ð´Ð° ÑÐ»ÑÐ¾ÑÐµÑÑÐµÐ½ÑÐ½Ð¾Ð¹ Ð¼Ð¸ÐºÑÐ¾ÑÐºÐ¾Ð¿Ð¸Ð¸ in vivo
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Analysis of the neuronal activity of the dorsal hippocampus neurons during behavioral testing using the method of fluorescence microscopy in vivo
Creators: name: ÐÑÐ¸ÑÐ¸Ð½Ð°, ÐÐ»Ð¸Ð·Ð°Ð²ÐµÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2023
Subjects: Ð½ÐµÐ¹ÑÐ¾Ð½Ð½Ð°Ñ ÑÐµÑÑ
Ð³Ð¸Ð¿Ð¿Ð¾ÐºÐ°Ð¼Ð¿
Ca2+ Ð½ÐµÐ¹ÑÐ¾Ð½Ð°Ð»ÑÐ½Ð°Ñ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ
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ÑÐ²Ð¾Ð±Ð¾Ð´Ð½Ð¾Ðµ Ð¿Ð¾Ð²ÐµÐ´ÐµÐ½Ð¸Ðµ
ÑÐµÑÑ Ð½Ð° ÑÑÐ»Ð¾Ð²Ð½Ð¾-ÑÐµÑÐ»ÐµÐºÑÐ¾ÑÐ½Ð¾Ðµ Ð·Ð°Ð¼Ð¸ÑÐ°Ð½Ð¸Ðµ
neural network
hippocampus
Ð¡a2+ neuronal activity
miniature fluorescent microscope
free behavior
fear conditioning

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description: The neurons of the CA1 region of the hippocampus are the central object of modern research, since this structure is important for processing many types of information, memory consolidation and decision-making, and its dysfunction is crucial in the manifestation and development of neurodegenerative diseases. Combination of methods such as miniature fluorescence microscopy and behavioral tests made it possible to analyze the calcium neuronal activity of the CA1 region of the dorsal hippocampus of wild-type mice in free behavior and in a fear conditioning test. As a result, it was shown that the neural network of an animal under constant conditions is characterized by stability and connectivity. In the behavioral paradigm of fear, animals have developed a conditioned reflex in response to the conditioned stimulus presentation (sound). The analysis of the functioning of the neural network indicates qualitative and quantitative changes in the work of cellular ensembles of the hippocampus, both during the initial presentation of conditional irritability, and during testing of conditional long-term memory of fear. The results are important for understanding the morphofunctional organization of the neural network of the CA1 region of the hippocampus.