cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Injectable, Ribbon-Like Microconfetti Biopolymer Platform for Vaccine Applications
Creators: name: Ainslie, Kristy M.
name: Stiepel, Rebeca T.
name: Batty, Cole J.
name: Bachelder, Eric M.
name: Genito, Christopher J.
name: Moore, Kathryn M.
Publisher: name: American Chemical Society (ACS)
Year: 2020

description: Previously, high-aspect- ratio ribbon-like microconfetti (MC) composed of acetalated dextran (Ace-DEX) have been shown to form a subcutaneous depot for sustained drug release. In this study, MC were explored as an injectable vaccine platform. Production of MC by electrospinning followed by high-shear homogenization allowed for precise control over MC fabrication. Three distinct sizes of MC, small (0.67 x 10.2 μm2), medium (1.28 x 20.7 μm2), and large (5.67 x 90.2 μm2), were fabricated and loaded with the adjuvant, resiquimod. Steady release rates of resiquimod were observed from MC, indicating their ability to create an immunostimulatory depot in vivo. Resiquimod-loaded MC stimulated inflammatory cytokine production in bone marrow-derived dendritic cells without incurring additional cytotoxicity in vitro. Interestingly, even medium and large MC were able to be internalized by antigen-presenting cells and facilitate antigen presentation when ovalbumin was adsorbed onto their surface. After subcutaneous injection in vivo with adsorbed ovalbumin, blank MC of all sizes were found to stimulate a humoral response. Adjuvant activity of resiquimod was enhanced by loading it into MC and small- and medium-sized MC effectively induced a Th1-skewed immune response. Antigen co-delivered with adjuvant-loaded MC of various sizes illustrates a new potential vaccine platform.
COMPARISON OF LABORATORY CONTAMINATION THROUGH OPEN AND CLOSED DOORS IN A MODEL SYSTEM
Creators: name: Galvin, Michael L.
Publisher: name: Maryland Shared Open Access Repository
Year: 1984

description: The results of this research demonstrate that with corridors at a higher air pressure than adjoining rooms, rooms with open doors receive greater contamination than rooms with closed doors. Examination of the data by an analysis of variance (ANOVA), employing a significance level of 0.05, yielded a P value of 4.9 x 10­­­­­¯¹² for the effect of door condition. The average contamination level for test rooms with open doors was four times greater than that for test rooms with closed doors. Diffusion and local air turbulence in the corridor are probably responsible for the greater contamination of rooms with open doors. With doors closed, increasing the pressure differential significantly increased test room contamination. The closed door P value for the effect of pressure differential was 7.3 x 10­­­­­¯⁹. When room doors were closed, increasing the pressure differential from 0.005 to 0.02 inches of water doubled the average test room contamination. With doors open, the pressure differential had much less significance than with doors closed. The open door P value for the effect of pressure differential was 0.046. Location of test rooms, relative to source room, affected their contamination levels in both open and closed door experiments. This occurred because the swing of the source room door resulted in a directional distribution of tracer which affected the rooms differently.
exceptional influx and successful breeding of Pantala flavescens on the Island of Malta (Maltese Archipelago) (Odonata: Libellulidae)
Creators: name: GAUCI, Charles
Publisher: name: Fragmenta entomologica
Year: 2022

description: Pantala flavescens (Fabricius 1798) appeared in unprecedented numbers in summer and autumn 2020 on the island of Malta. Several males were observed holding territory over largely bare, small bodies of water, mostly at Chadwick Lakes and Fiddien. Breeding activity was witnessed several times and 128 exuviae were found of which 124 were collected.
description: Fragmenta entomologica, Vol. 54 No. 2 (2022)
APPLICATION OF ELECTRIC FIELDS TO CONTROL POPULATION GROWTH OF Dunaliella tertiolecta IN VITRO
Creators: name: Garcia, Patricia
Publisher: name: Maryland Shared Open Access Repository
Year: 2008

description: Algae blooms are naturally occurring phenomena that exist worldwide. Harmful blooms can create a noxious kill zone capable of suffocating fish and poisoning people. This paper explores the application of electrical fields as a way to control growth in an in vitro population of the green algae Dunaliella tertiolecta. Previous studies have shown pulses of electricity effective in the induction of programmed cell death in mammalian cells. Our results demonstrate that from the different currents applied, 40mA appears to be the lowest current at which we found significant difference between the mean number of cells in sample and control wells. The number of pulses applied was also important to obtain inactivation. Results show that by applying direct current to a population of Dunaliella tertiolecta in vitro we can affect motility and division of cells.
Lemay_Online_Appendix – Supplemental material for Common Ingroup Identity, Perceived Similarity, and Communal Interracial Relationships
Creators: name: Lemay, Edward P.
name: Ryan, Joshua E.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, Lemay_Online_Appendix for Common Ingroup Identity, Perceived Similarity, and Communal Interracial Relationships by Edward P. Lemay and Joshua E. Ryan in Personality and Social Psychology Bulletin
"ҲУДУД УЛ-ОЛАМ" АСАРИДА ЎРТА ОСИЁНИНГ ДЕНГИЗ ВА ДАРЁЛАРИ ҲАҚИДАГИ МАЪЛУМОТЛАР
Creators: name: Бобораҳимов, Зикирё
Publisher: name: Zenodo
Year: 2024

description: Ўрта Осиёнинг ижтимоий-иқтисодий тараққиёти суғориш тизими билан боғлиқлиги маълум. Суғориш тизими ҳозирги кунда ҳам иқтисодиётнинг энг муҳим тармоқларидан бири ҳисобланади. “Орол фожеаси” ва Ўрта Осиёда сувга бўлган талабнинг табора кенгайиб бораётганлиги сув масаласини ҳам янада муҳим масала эканлигини эслатмоқда, дейиш мумкин.  Шунинг учун ҳам ўрта асрларда Ўрта Осиёнинг сув манбаларини қандай бўлганлигини ўрганиб бориш ҳозирги кунда ҳам қизиқарлидир. Биз ўрганаётган “Ҳудуд ул-олам” асарида ҳам бу борада кўплаб фикрлар учрайди.
sj-pdf-1-std-10.1177_0956462420915388 - Supplemental material for Estimating prevalence and incidence of sexually transmitted infections among South African women: Implications of combined impacts of risk factors
Creators: name: Wand, Handan
name: Tarylee Reddy
name: Reshmi Dassaye
name: Jothi Moodley
name: Naidoo, Sarita
name: Ramjee, Gita
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-1-std-10.1177_0956462420915388 for Estimating prevalence and incidence of sexually transmitted infections among South African women: Implications of combined impacts of risk factors by Handan Wand, Tarylee Reddy, Reshmi Dassaye, Jothi Moodley, Sarita Naidoo and Gita Ramjee in International Journal of STD & AIDS
THE EFFECT OF FISH HATCHERY EFFLUENT ON PERIPHYTON IN FISHING CREEK, FREDERICK COUNTY, MARYLAND
Creators: name: Gardetto, Edward C.
Publisher: name: Maryland Shared Open Access Repository
Year: 1996

description: An assessment was performed on a second order stream in Frederick County, Maryland, to determine the effect of aquaculture ponds on the periphyton community. Artificial substrate periphyton samplers were placed in the stream at locations above and below the aquaculture facilities for a 26 day period. Variables affecting periphyton growth (light intensity, stream velocity, and stream depth) were monitored for each location. Water chemistry analysis was performed to determine chemical changes caused by the aquaculture. A generic taxonomic analysis of algae was performed at sites above and below the aquaculture facilities. Published methodology for periphyton and chemical analysis were adapted and used for this study. Chlorophyll-a (mass meter­­­­­¯²) and Ash-Free Dry Weight (mass meter­­­­­¯²) were found to be statistically higher downstream of the aquaculture facilities when controlling for stream velocity. The Autotrophic Index was found not to be impacted by the aquaculture but was related to stream velocity. Problems with the extraction efficiency of chlorophyll-a may have caused an under reporting of chlorophyll-a mass and therefore an over reporting of Autotrophic Index numbers. Chemical analysis of the stream showed little impact from the aquaculture facilities. Although the aquaculture facilities appear to cause an impact on the periphyton community, the level of impact appears small.
The Possible Use of Untreated Municipal Mass Burn Residues in Highway Subbase Construction
Creators: name: Gardner, Timothy Nevill
Publisher: name: Maryland Shared Open Access Repository
Year: 1984

description: Four samples of mass burn residues were collected from four different municipal facilities and examined to determine their structural suitability for highway subbase construction. One sample was bottom ash only, and the other three were mixtures of fly and bottom ash. Laboratory procedures were used to determine the following; water content, particle size distribution, physical description, moisture-density relationships, loss on ignition, presence of organic impurities, and classification of each sample. A literature search was used to explore the environmental implications of residue use in subbase construction. Two of the samples appeared to be structurally acceptable for subbase material. One sample lacked an acceptable particle size distribution and had a very high loss on ignition value. The fourth sample had a high loss on ignition value and a high amount of organic impurity. Sound engineering practices during construction of a highway subbase can offer an acceptable degree of residue encapsulation, and use as subbase material could be a viable option for residue disposal or use.
Crystal structure analyses of some biologically active compounds
Creators: name: Sindt Josem, Anne Christine
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 300304
subject: Animal protection (incl. pests and pathogens)
classificationCode: 310101
subject: Analytical biochemistry
classificationCode: 340202
subject: Crystallography
classificationCode: 510501
subject: Biological physics

description: Submission note: A thesis submitted for the degree of Doctor of Philosophy to the Department of Physical Chemistry, School of Physical Sciences, La Trobe University.File attached "Observed and Calculated Structure Amplitudes" is Appendix C, originally included on microfiche.
Agromyza apfelbecki Strobl 1902
Creators: name: Ebejer, Martin J.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Agromyzidae
Agromyza
Agromyza apfelbecki

description: Agromyza apfelbecki Strobl, 1902
 Material examined: one of the most frequently encountered species in this study. A common and predominantly Mediterranean species. First recorded from Malta by Spencer (1973a).
description: Published as part of Ebejer, Martin J., 2021, The leaf-mining flies of the family Agromyzidae of the Maltese Islands are revisited and updated with new data and records (Diptera: Brachycera, Acalyptrata), pp. 93-104 in Fragmenta entomologica 53 (1) on page 94, DOI: 10.13133/2284-4880/487, http://zenodo.org/record/12762234
THE TISSUE-SPECIFICITY OF MOUSE Ets-1 REGULATORY REGION IN A TRANSGENIC MODEL
Creators: name: Garrett, Lisa J.
Publisher: name: Maryland Shared Open Access Repository
Year: 1994

description: Cellular differentiation is the result of the selective expression of gene products that determine cellular phenotype. To identify the cis - acting control elements of developmentally-regulated genes, it is necessary to be able to identify genetic regions that direct tissue- specific expression in a developmental system. Transgenic analysis involves the introduction of cloned genes into mice by pronuclear injection of fertilized eggs. This method allows for a comprehensive analysis of the temporal and tissue-specific expression of a developmentally-regulated gene. Recently, Ets-1, a developmentally-regulated protooncogene, was determined by in situ analysis to be expressed in various tissues during mouse development and at high levels in the lymphoid and vascular structures. The Ets-1 gene product is a DNA-binding protein that may function in the regulation of many genes through interactions with specific nucleotide sequences in gene promoters. To better understand the regulation of Ets-1, further analysis is required to identify tissue-specificity and control regions that regulate expression. In this thesis, 2.4 kb of the 5' flanking region of the Ets-1 promoter was fused to the lacZ gene and microinjected into mouse pronuclei. Transgenic mice expressed the Ets-1/lacZ fusion gene aberrantly in the central nervous system. No detectable lymphoid or vascular expression was observed. However, certain transgenic expression showed positive correlation with the in situ analysis. These results indicate that the "functional" promoter of Ets-1 previously described by several labs (Jorcyk et al., 1991, and Marjeus et al., 1992) is not sufficient to facilitate tissue-specific expression. Therefore, lymphoid and vascular-specific enhancers must still be identified in the molecular organization of Ets-1. Furthermore, negative regulatory elements may be present in Ets-1 that suppress neuronal expression.
Insula Dynorphin and Kappa Opioid Receptor Systems Regulate Alcohol Drinking in a Sex-Specific Manner in Mice.
Creators: name: D'Ambrosio, Shannon
name: Stanhope, Christina M
name: Kash, Thomas L
name: Mahoney, Alexandra A
name: Pina, Melanie M
name: Taxier, Lisa R
name: Navarro, Montserrat
name: Pati, Dipanwita
name: Neira, Sofia
Publisher: name: Society for Neuroscience
Year: 2023

description: Alcohol use disorder is complex and multifaceted, involving the coordination of multiple signaling systems across numerous brain regions. Previous work has indicated that both the insular cortex and dynorphin (DYN)/kappa opioid receptor (KOR) systems contribute to excessive alcohol use. More recently, we identified a microcircuit in the medial aspect of the insular cortex that signals through DYN/KOR. Here, we explored the role of insula DYN/KOR circuit components on alcohol intake in a long-term intermittent access (IA) procedure. Using a combination of conditional knock-out strategies and site-directed pharmacology, we discovered distinct and sex-specific roles for insula DYN and KOR in alcohol drinking and related behavior. Our findings show that insula DYN deletion blocked escalated consumption and decreased the overall intake of and preference for alcohol in male and female mice. This effect was specific to alcohol in male mice, as DYN deletion did not impact sucrose intake. Further, insula KOR antagonism reduced alcohol intake and preference during the early phase of IA in male mice only. Alcohol consumption was not affected by insula KOR knockout in either sex. In addition, we found that long-term IA decreased the intrinsic excitability of DYN and deep layer pyramidal neurons (DLPNs) in the insula of male mice. Excitatory synaptic transmission was also impacted by IA, as it drove an increase in excitatory synaptic drive in both DYN neurons and DLPNs. Combined, our findings suggest there is a dynamic interplay between excessive alcohol consumption and insula DYN/KOR microcircuitry.SIGNIFICANCE STATEMENT The insular cortex is a complex region that serves as an integratory hub for sensory inputs. In our previous work, we identified a microcircuit in the insula that signals through the kappa opioid receptor (KOR) and its endogenous ligand dynorphin (DYN). Both the insula and DYN/KOR systems have been implicated in excessive alcohol use and alcohol use disorder (AUD). Here, we use converging approaches to determine how insula DYN/KOR microcircuit components contribute to escalated alcohol consumption. Our findings show that insula DYN/KOR systems regulate distinct phases of alcohol consumption in a sex-specific manner, which may contribute to the progression to AUD.
Supplementary_Table_S1 – Supplemental material for Effect of Dexmedetomidine on Delirium in Elderly Surgical Patients: A Meta-analysis of Randomized Controlled Trials
Creators: name: Chunmei Lin
name: Hankun Tu
name: Zhixuan Jie
name: Xinkai Zhou
name: Chaoyang Li
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine

description: Supplemental material, Supplementary_Table_S1 for Effect of Dexmedetomidine on Delirium in Elderly Surgical Patients: A Meta-analysis of Randomized Controlled Trials by Chunmei Lin, Hankun Tu, Zhixuan Jie, Xinkai Zhou and Chaoyang Li in Annals of Pharmacotherapy
Agromyza frontella
Creators: name: Ebejer, Martin J.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Agromyzidae
Agromyza
Agromyza frontella

description: Agromyza frontella (Rondani, 1875)
 Material examined: 1♂, Malta: Buskett, 22 Apr 1992; 3♂♂, 4♀♀, Gozo: Ramla dunes, 5 Apr 1999.
 A common and widespread Holarctic species. A pest of alfalfa. New record for the Maltese Islands.
description: Published as part of Ebejer, Martin J., 2021, The leaf-mining flies of the family Agromyzidae of the Maltese Islands are revisited and updated with new data and records (Diptera: Brachycera, Acalyptrata), pp. 93-104 in Fragmenta entomologica 53 (1) on page 94, DOI: 10.13133/2284-4880/487, http://zenodo.org/record/12762234
Development of the Medaka Liver: An Ultrastructural and Morphometric Analysis.
Creators: name: Geisbert, Thomas W.
Publisher: name: Maryland Shared Open Access Repository
Year: 1988

description: The ultrastructure of the liver of medaka (Oryzias latipes) was analyzed at particular stages of development to establish a base-line for investigations concerning carcinogenicity of hepatic tissue. Specifically, hepatic cell types were characterized during the first, sixth, and thirteenth weeks of development. Ten fish from each stage were randomly selected and sacrificed; seven were processed for transmission electron microscopy and three for light microscopy. Cell types observed in medaka liver included hepatocytes, sinusoidal endothelial lining cells, fat storing cells of Ito, bile preductular lining cells, and columnar epithelial cells lining bile ducts. Ultrastructural changes associated with normal liver development were evident in hepatocytes. Increases in lipid content, cytoskeletal components, organelles asociated with secretion, and large decreases in glycogen became evident as liver development progressed. Sinusoidal lining cells were characterized by fenestrated cytoplasmic extensions at all stages of development. Bile preductular lining cells contributed few microvilli to bile ductules and displayed significant increases in the concentration of microfilaments with age. Microvilli were present on the luminal surfaces of columnar epithelial cells of the bile duct. Ito cells, in most instances, were laden with lipid droplets and microfilaments regardless of age. Statistical analysis of morphometric data indicated no significant difference in nuclear to cytoplasm ratios of hepatocytes during development. The number of bile preductular lining cells progressively increased as the liver developed. The volume of lipid droplets increased significantly with age.
Agromyza graminicola Hendel 1931
Creators: name: Ebejer, Martin J.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Agromyzidae
Agromyza
Agromyza graminicola

description: Agromyza graminicola Hendel, 1931
 Material examined: 5♂♂, 1♀, Malta: Salina, 11 Apr 1994; 2♂♂, 2♀♀, Salina, 22 Apr 1994, JCD leg. & det. (NMWC, 1♂, MJE coll.); 4♂♂, 1♀, Fiddien, 20 May 1995, B. Merz; 2♂♂, 2♀♀, Salina, 7 May 2002.
 An uncommon species though widespread in Europe. The host plant is Phragmites. New record for the Maltese Islands.
description: Published as part of Ebejer, Martin J., 2021, The leaf-mining flies of the family Agromyzidae of the Maltese Islands are revisited and updated with new data and records (Diptera: Brachycera, Acalyptrata), pp. 93-104 in Fragmenta entomologica 53 (1) on page 94, DOI: 10.13133/2284-4880/487, http://zenodo.org/record/12762234
sj-pdf-2-gcq-10.1177_0016986220932533 - Supplemental material for Similarities and Differences Between Intellectually Gifted and Average-Ability Students in School Performance, Motivation, and Subjective Well-Being
Creators: name: Bergold, Sebastian
name: Wirthwein, Linda
name: Steinmayr, Ricarda
Publisher: name: SAGE Journals
Year: 2020
Subjects: Education

description: Supplemental material, sj-pdf-2-gcq-10.1177_0016986220932533 for Similarities and Differences Between Intellectually Gifted and Average-Ability Students in School Performance, Motivation, and Subjective Well-Being by Sebastian Bergold, Linda Wirthwein and Ricarda Steinmayr in Gifted Child Quarterly
Supplementary document for Integrated chirped photonic-crystal cavities in gallium phosphide for broadband soliton generation - 7177486.pdf
Creators: name: Nardi, Alberto
name: Davydova, Alisa
name: Kuznetsov, Nikolai
name: Anderson, Miles
name: Möhl, Charles
name: Riemensberger, Johann
name: Kippenberg, Tobias
name: Seidler, Paul
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary Information
sj-pdf-1-hsm-10.1177_0951484820948647 - Supplemental material for The effects of hospital-physician financial integration on adverse incident rate: An agency theory perspective
Creators: name: Upadhyay, Soumya
name: Weech-Maldonado, Robert
name: Opoku-Agyeman, William
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified

description: Supplemental material, sj-pdf-1-hsm-10.1177_0951484820948647 for The effects of hospital-physician financial integration on adverse incident rate: An agency theory perspective by Soumya Upadhyay, Robert Weech-Maldonado and William Opoku-Agyeman in Health Services Management Research
Agromyza hiemalis Becker 1908
Creators: name: Ebejer, Martin J.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Agromyzidae
Agromyza
Agromyza hiemalis

description: Agromyza hiemalis Becker, 1908
 Material examined: 1♀, Malta: Balzan, 28 Mar 1977; 1♀, Balzan, 9 Mar 1992; 1♂, Buskett, 27 Mar 1997; 1♂, Salina, 10 Jan 1999; 2♂♂, Qormi, Ghemmieri, 11 Dec 1999.
 A Mediterranean species first recorded from Malta by Spencer (1973a) from mines on Urtica urens.
description: Published as part of Ebejer, Martin J., 2021, The leaf-mining flies of the family Agromyzidae of the Maltese Islands are revisited and updated with new data and records (Diptera: Brachycera, Acalyptrata), pp. 93-104 in Fragmenta entomologica 53 (1) on page 94, DOI: 10.13133/2284-4880/487, http://zenodo.org/record/12762234
Integrating Objective and Subjective Social Class to Advance Our Understanding of Externalizing Problem Behavior in Children and Adolescents: A Conceptual Review and Model
Creators: name: Jones, Deborah J.
name: Highlander, April R.
Publisher: name: Springer Nature
Year: 2021

description: Extant research has identified both objective measures of socioeconomic status (SES) and subjective social class (SSC) as important predictors of psychosocial outcomes in childhood and adolescence, particularly with regard to externalizing symptoms. Given the importance of the associations with SES and SSC, a more nuanced and integrated conceptual understanding of early pathways of vulnerability implicated in the development and maintenance of youth externalizing problems is warranted. Thus, this review will: (1) operationalize both SES and SSC and their current standards of measurement; (2) examine current literature describing their respective associations with a range of externalizing symptoms in both children and adolescents; (3) review current theoretical models connecting SES and SSC and youth development and the strengths and limitations of those approaches; (4) propose a new conceptual socioecological model situating the impact of SES and SSC on youth externalizing problems in the context of parents and peers as a framework to further integrate existing research and guide future work; and (5) discuss potential clinical implications at the intersection of this work.
COMPARING THE COMPREHENSION OF PARENTAL INFORMED CONSENT AND THE CORRESPONDING MINOR ASSENT DOCUMENT
Creators: name: Giambarresi, Leah
Publisher: name: Maryland Shared Open Access Repository
Year: 2010

description: The informed consent process has had a long history which led to the development of explicit requirements regarding the information disclosed to adult subjects in clinical trials. There are very few similar requirements for the information that is disclosed to a minor who participates in the same research. This study aims to examine the difference in the understanding of an adult consent document as compared to its respective child assent document from the same trial. Two document pairs were selected based upon the presence of the 14 required and additional elements of informed consent as described in 21 CFR 50.25. In the first pair ("consistent"), there was very little difference in the number of these elements presented; the second pair ("inconsistent") had a far greater difference. A total of 131 volunteers each read one of the documents and answered a series of written questions designed to analyze their understanding of the trial and their feelings about participation. Results were tabulated, and the difference in understanding between each consent and its respective assent was calculated. Then, the differences in understanding between the two pairs were compared. Analysis showed an approximate 20% difference in understanding between the pairs. Data was also analyzed to determine how the lack of elements in the assent documents would affect the volunteer s willingness to participate. Close to 40% of the individuals in both assent groups who declined to participate in the described trial attributed this decision to the lack of at least one element. This diminished understanding and difference in participation suggest that a reevaluation of the assent process may be useful in order to respect the autonomy of the minor clinical trial participant.
Integrative radiomics expression predicts molecular subtypes of primary clear cell renal cell carcinoma
Creators: name: Wang, L.
name: Lin, W.
name: Woods, M.E.
name: Khandani, A.H.
name: Yin, Q.
name: Hung, S.-C.
name: Rathmell, W.K.
name: Brooks, S.A.
name: Shen, L.
name: Milowsky, M.I.
name: Shen, D.
name: Wallen, E.M.
name: Fielding, J.R.
Publisher: name: Elsevier
Year: 2018

description: AIM: To identify combined positron-emission tomography (PET)/magnetic resonance imaging (MRI)-based radiomics as a surrogate biomarker of intratumour disease risk for molecular subtype ccA and ccB in patients with primary clear cell renal cell carcinoma (ccRCC). MATERIALS AND METHODS: PET/MRI data were analysed retrospectively from eight patients. One hundred and sixty-eight radiomics features for each tumour sampling based on the regionally sampled tumours with 23 specimens were extracted. Sparse partial least squares discriminant analysis (SPLS-DA) was applied to feature screening on high-throughput radiomics features and project the selected features to low-dimensional intrinsic latent components as radiomics signatures. In addition, multilevel omics datasets were leveraged to explore the complementing information and elevate the discriminative ability. RESULTS: The correct classification rate (CCR) for molecular subtype classification by SPLS-DA using only radiomics features was 86.96% with permutation test p=7x10-4. When multi-omics datasets including mRNA, microvascular density, and clinical parameters from each specimen were combined with radiomics features to refine the model of SPLS-DA, the best CCR was 95.65% with permutation test, p<10-4; however, even in the case of generating the classification based on transcription features, which is the reference standard, there is roughly 10% classification ambiguity. Thus, this classification level (86.96-95.65%) of the proposed method represents the discriminating level that is consistent with reality. CONCLUSION: Featured with high accuracy, an integrated multi-omics model of PET/MRI-based radiomics could be the first non-invasive investigation for disease risk stratification and guidance of treatment in patients with primary ccRCC.
Interleaved 3D-CNNs for joint segmentation of small-volume structures in head and neck CT images
Creators: name: Shao, Yeqin
name: Zhang, Huan
name: Shen, Dinggang
name: Ren, Xuhua
name: Wang, Qian
name: Xiang, Lei
name: Nie, Dong
Publisher: name: Wiley
Year: 2018

description: PURPOSE: Accurate 3D image segmentation is a crucial step in radiation therapy planning of head and neck tumors. These segmentation results are currently obtained by manual outlining of tissues, which is a tedious and time-consuming procedure. Automatic segmentation provides an alternative solution, which, however, is often difficult for small tissues (i.e., chiasm and optic nerves in head and neck CT images) because of their small volumes and highly diverse appearance/shape information. In this work, we propose to interleave multiple 3D Convolutional Neural Networks (3D-CNNs) to attain automatic segmentation of small tissues in head and neck CT images. METHOD: A 3D-CNN was designed to segment each structure of interest. To make full use of the image appearance information, multiscale patches are extracted to describe the center voxel under consideration and then input to the CNN architecture. Next, as neighboring tissues are often highly related in the physiological and anatomical perspectives, we interleave the CNNs designated for the individual tissues. In this way, the tentative segmentation result of a specific tissue can contribute to refine the segmentations of other neighboring tissues. Finally, as more CNNs are interleaved and cascaded, a complex network of CNNs can be derived, such that all tissues can be jointly segmented and iteratively refined. RESULT: Our method was validated on a set of 48 CT images, obtained from the Medical Image Computing and Computer Assisted Intervention (MICCAI) Challenge 2015. The Dice coefficient (DC) and the 95% Hausdorff Distance (95HD) are computed to measure the accuracy of the segmentation results. The proposed method achieves higher segmentation accuracy (with the average DC: 0.58 ± 0.17 for optic chiasm, and 0.71 ± 0.08 for optic nerve; 95HD: 2.81 ± 1.56 mm for optic chiasm, and 2.23 ± 0.90 mm for optic nerve) than the MICCAI challenge winner (with the average DC: 0.38 for optic chiasm, and 0.68 for optic nerve; 95HD: 3.48 for optic chiasm, and 2.48 for optic nerve). CONCLUSION: An accurate and automatic segmentation method has been proposed for small tissues in head and neck CT images, which is important for the planning of radiotherapy.
DEVELOPMENT OF A METHOD TO IDENTIFY CANCER STEM CELLS IN SOLID TUMORS
Creators: name: Gignac, Michelle
Publisher: name: Maryland Shared Open Access Repository
Year: 2007

description: Recently, there has been an abundance of research on the presences of stem cells in solid tumors. Cancer stem cells are characterized as those cells capable of regenerating a tumor (1-3). Not all tumor cells have this ability. These cancer stem cells make up only a small fraction of the tumor, but are resistant to chemotherapies and radiation treatments (2). These cells may also lead to metastases to other locations (3). We propose to develop a method to identify the cancer stem cells in solid tumor biopsies. This will enable researchers to study the arrangement of the stem cells within the tumor and their interactions with the surrounding cells. If this method is adapted to the clinical arena, knowing the number of stem cells in a solid tumor could lead to better treatment selections and higher patient survival rates.
Agromyza nana Meigen 1830
Creators: name: Ebejer, Martin J.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Agromyzidae
Agromyza
Agromyza nana

description: Agromyza nana Meigen, 1830
 Material examined: 1♀, Malta: Fawwara, 18 Mar 1992; 1♂, 1♀, Ghadira, 9 Apr 1993, leg. and coll. PG.
 A common species in the Mediterranean and first recorded from Malta by Spencer (1973a) from leaf mines on Medicago.
description: Published as part of Ebejer, Martin J., 2021, The leaf-mining flies of the family Agromyzidae of the Maltese Islands are revisited and updated with new data and records (Diptera: Brachycera, Acalyptrata), pp. 93-104 in Fragmenta entomologica 53 (1) on page 94, DOI: 10.13133/2284-4880/487, http://zenodo.org/record/12762234
Supplementary document for Ultrafast filtered back-projection for photoacoustic computed tomography - 7177505.pdf
Creators: name: Liu, Songde
name: Tan, Zhijian
name: Shao, Pengfei
name: Wang, Sheng
name: Tian, Chao
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement 1
Gruber_Supplemental_Material_Table_S1 – Supplemental material for The Future of Women in Psychological Science
Creators: name: Gruber, June
name: Mendle, Jane
name: Lindquist, Kristen A.
name: Schmader, Toni
name: Clark, Lee Anna
name: Bliss-Moreau, Eliza
name: Modupe Akinola
name: Atlas, Lauren
name: Barch, Deanna M.
name: Barrett, Lisa Feldman
name: Borelli, Jessica L.
name: Brannon, Tiffany N.
name: Bunge, Silvia A.
name: Campos, Belinda
name: Cantlon, Jessica
name: Carter, Rona
name: Carter-Sowell, Adrienne R.
name: Chen, Serena
name: Craske, Michelle G.
name: Cuddy, Amy J. C.
name: Crum, Alia
name: Davachi, Lila
name: Duckworth, Angela L.
name: Dutra, Sunny J.
name: Eisenberger, Naomi I.
name: Ferguson, Melissa
name: Ford, Brett Q.
name: Fredrickson, Barbara L.
name: Goodman, Sherryl H.
name: Gopnik, Alison
name: Greenaway, Valerie Purdie
name: Harkness, Kate L.
name: Mikki Hebl
name: Heller, Wendy
name: Hooley, Jill
name: Jampol, Lily
name: Johnson, Sheri L.
name: Joormann, Jutta
name: Kinzler, Katherine D.
name: Kober, Hedy
name: Kring, Ann M.
name: Paluck, Elizabeth Levy
name: Lombrozo, Tania
name: Lourenco, Stella F.
name: Kateri McRae
name: Monin, Joan K.
name: Moskowitz, Judith T.
name: Natsuaki, Misaki N.
name: Oettingen, Gabriele
name: Pfeifer, Jennifer H.
name: Prause, Nicole
name: Saxbe, Darby
name: Smith, Pamela K.
name: Spellman, Barbara A.
name: Sturm, Virginia
name: Teachman, Bethany A.
name: Thompson, Renee J.
name: Weinstock, Lauren M.
name: Williams, Lisa A.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: Neuroscience

description: Supplemental material, Gruber_Supplemental_Material_Table_S1 for The Future of Women in Psychological Science by June Gruber, Jane Mendle, Kristen A. Lindquist, Toni Schmader, Lee Anna Clark, Eliza Bliss-Moreau, Modupe Akinola, Lauren Atlas, Deanna M. Barch, Lisa Feldman Barrett, Jessica L. Borelli, Tiffany Brannon, Silvia A. Bunge, Belinda Campos, Jessica Cantlon, Rona Carter, Adrienne R. Carter-Sowell, Serena Chen, Michelle G. Craske, Amy J. C. Cuddy, Alia Crum, Lila Davachi, Angela L. Duckworth, Sunny J. Dutra, Naomi I. Eisenberger, Melissa Ferguson, Brett Q. Ford, Barbara L. Fredrickson, Sherryl H. Goodman, Alison Gopnik, Valerie Purdie Greenaway, Kate L. Harkness, Mikki Hebl, Wendy Heller, Jill Hooley, Lily Jampol, Sheri L. Johnson, Jutta Joormann, Katherine D. Kinzler, Hedy Kober, Ann M. Kring, Elizabeth Levy Paluck, Tania Lombrozo, Stella F. Lourenco, Kateri McRae, Joan K. Monin, Judith T. Moskowitz, Misaki N. Natsuaki, Gabriele Oettingen, Jennifer H. Pfeifer, Nicole Prause, Darby Saxbe, Pamela K. Smith, Barbara A. Spellman, Virginia Sturm, Bethany A. Teachman, Renee J. Thompson, Lauren M. Weinstock and Lisa A. Williams in Perspectives on Psychological Science
Intercalation of Layered Materials from Bulk to 2D
Creators: name: Martens, Sean J.
name: Kuntz, Kaci L.
name: Warren, Scott C.
name: Stark, Madeline S.
Publisher: name: Wiley
Year: 2019

description: Intercalation in few-layer (2D) materials is a rapidly growing area of research to develop next-generation energy-storage and optoelectronic devices, including batteries, sensors, transistors, and electrically tunable displays. Identifying fundamental differences between intercalation in bulk and 2D materials will play a key role in developing functional devices. Herein, advances in few-layer intercalation are addressed in the historical context of bulk intercalation. First, synthesis methods and structural properties are discussed, emphasizing electrochemical techniques, the mechanism of intercalation, and the formation of a solid-electrolyte interphase. To address fundamental differences between bulk and 2D materials, scaling relationships describe how intercalation kinetics, structure, and electronic and optical properties depend on material thickness and lateral dimension. Here, diffusion rates, pseudocapacity, limits of staging, and electronic structure are compared for bulk and 2D materials. Next, the optoelectronic properties are summarized, focusing on charge transfer, conductivity, and electronic structure. For energy devices, opportunities also emerge to design van der Waals heterostructures with high capacities and excellent cycling performance. Initial studies of heterostructured electrodes are compared to state-of-the-art battery materials. Finally, challenges and opportunities are presented for 2D materials in energy and optoelectronic applications, along with promising research directions in synthesis and characterization to engineer 2D materials for superior devices.
Interoception and alcohol: Mechanisms, networks, and implications
Creators: name: Besheer, Joyce
name: Tyler, Ryan E
name: Lovelock, Dennis F
Publisher: name: Elsevier
Year: 2021

description: Interoception refers to the perception of the internal state of the body and is increasingly being recognized as an important factor in mental health disorders. Drugs of abuse produce powerful interoceptive states that are upstream of behaviors that drive and influence drug intake, and addiction pathology is impacted by interoceptive processes. The goal of the present review is to discuss interoceptive processes related to alcohol. We will cover physiological responses to alcohol, how interoceptive states can impact drinking, and the recruitment of brain networks as informed by clinical research. We also review the molecular and brain circuitry mechanisms of alcohol interoceptive effects as informed by preclinical studies. Finally, we will discuss emerging treatments with consideration of interoception processes. As our understanding of the role of interoception in drug and alcohol use grows, we suggest that the convergence of information provided by clinical and preclinical studies will be increasingly important. Given the complexity of interoceptive processing and the multitude of brain regions involved, an overarching network-based framework can provide context for how focused manipulations modulate interoceptive processing as a whole. In turn, preclinical studies can systematically determine the roles of individual nodes and their molecular underpinnings in a given network, potentially suggesting new therapeutic targets and directions. As interoceptive processing drives and influences motivation, emotion, and subsequent behavior, consideration of interoception is important for our understanding of processes that drive ongoing drinking and relapse.
A PLATFORM FOR THE SCREENING OF BREAST CANCER-ASSOCIATED POLYMORPHISIMS USING A PRIMER EXTENSION MICROARRAY
Creators: name: Gilbert, Joseph T.
Publisher: name: Maryland Shared Open Access Repository
Year: 2007

description: It is of great societal and scientific importance to be able to identify low penetrance polymorphic loci and the combinations of allelic variation that give the greatest risk to an individual for the development of breast cancer. Understanding about this variation will be beneficial both for diagnosis, prevention and in the development of drug targets for breast cancer. To this end I propose the creation of a diagnostic platform that will help to identify the risk factors associated with known or suspected polymorphic markers that may influence the progression of breast cancer. The platform that I propose would entail the creation of an oligonucleotide microarray consisting of oligonucleotide detection primers that would anneal to genomic DNA from a donor and detect polymorphic mutations among known and suspected breast cancer-associated alleles. Genomic DNA would be taken from a patient and then amplified. The loci of interest would be copied out of the genomic material by using a multiplexing PCR primer set. The amplified polymorphic loci would then be cleaned up and combined to create a hybridization probe for the microarray. Once the probe is hybridized to the microarray, a polymerase will then be added along with fluorescent-labeled dNTPs and the detection primer would be extended using the labeled dNTPs. This extension would only occur when there is a complete nucleotide match between the sample DNA from the patient and the detection primer's 3' end. A microarray scanner should be able to detect the presence of incorporated labeled nucleotides. The data from large scale studies using this platform coupled with the monitoring of an individual's medical history that has been genotyped using this method, could provide both scientists and clinicians with data available to make a better judgment regarding future risk and prevention of this disease.
title: MIKROBIELLE SYNERGIEN NUTZEN
title: VERWENDUNG VON LEITFÄHIGEN MATERIALIEN ZUR OPTIMIERUNG DES PROZESSES DER BIOGASPRODUKTION
titleType: AlternativeTitle
Creators: name: Principi, Pamela
name: Perego, Camilla
Publisher: name: My University
Year: 2025
Subjects: subject: sustainableDevelopmentGoal.goal7

description: In den anaeroben Fermentern von Biogasanlagen arbeitet eine Vielzahl unterschiedlicher Mikroorganismen zusammen, um Methan zu produzieren. Wie funktioniert dieses Zusammenspiel? Das empfindliche Gleichgewicht basiert auf einem komplexen Netz verschiedener chemischer Reaktionen. Eine wichtige Rolle spielt dabei die Wasserstoffkonzentration. Die Zugabe von leitfähigen Materialien beeinflusst die mikrobiellen Interaktionen, indem diese den Elektronentransfer ankurbeln, was wiederum die Biogasproduktion erhöht – eine innovative Strategie für eine verbesserte mikrobielle Leistung.
Melanagromyza siciliensis Spencer 1966
Creators: name: Ebejer, Martin J.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Agromyzidae
Melanagromyza
Melanagromyza siciliensis

description: Melanagromyza siciliensis Spencer, 1966
 Material examined: 2♂♂, Malta: Fiddien, 5 May 2002, B. Merz (NMWC); 1♂, 2♀♀, Gozo: Dwejra, 5 Apr 1999. This species appears to have a distribution limited to a few areas in central Europe and the Mediterranean. New record for the Maltese Islands.
description: Published as part of Ebejer, Martin J., 2021, The leaf-mining flies of the family Agromyzidae of the Maltese Islands are revisited and updated with new data and records (Diptera: Brachycera, Acalyptrata), pp. 93-104 in Fragmenta entomologica 53 (1) on page 95, DOI: 10.13133/2284-4880/487, http://zenodo.org/record/12762234
OVEREXPRESSION OF HUMAN P21­­ʷᵃᶠ¹⸍ᶜⁱᵖ¹ ARRESTS THE GROWTH OF CHICKEN EMBRYO FIBROBLASTS TRANSFORMED BY INDIVIDUAL ONCOGENES
Creators: name: Givol, Iris
Publisher: name: Maryland Shared Open Access Repository
Year: 1998

description: In normal cells, cell growth and division are controlled by the interplay between proto-oncogenes and tumor suppressor genes. Cancer cells usually have both activated an oncogene and lost a functional tumor suppressor gene. This study addresses the interrelationship between these positive and negative growth regulators. The main focus is on p21­­ʷᵃᶠ¹⸍ᶜⁱᵖ¹, a cyclin/cdk inhibitor whose expression is regulated by p53. High level expression of the p53 tumor suppressor can block the growth of cancer cells. Wafl/cipl is transactivated by p53 and the p21ʷᵃᶠ¹⸍ᶜⁱᵖ¹ protein is itself a suppressor of cell growth. To test the growth suppression effect of p21ʷᵃᶠ¹⸍ᶜⁱᵖ¹ or p53 on the growth of normal cells and cells transformed by individual oncogenes, we used replication-competent retroviral vectors to induce high level expression of p53 and p21ʷᵃᶠ¹⸍ᶜⁱᵖ¹ in chicken embryo fibroblasts (CEF). These are primary cells and by using them we avoid the complications that arise when such experiments are done with established cell lines. This study shows that overexpression of p21ʷᵃᶠ¹⸍ᶜⁱᵖ¹ or p53 arrests the growth of CEF at the G 1 phase of the cell cycle by inhibiting DNA synthesis. We next asked whether the growth inhibition induced by p21ʷᵃᶠ¹⸍ᶜⁱᵖ¹ could be overcome by mitogenic signals delivered by a variety of oncogenes. We show that the growth of CEF transformed by v-Src, tf-Ras, c-Mos and c-Myc is inhibited by overexpression of p21ʷᵃᶠ¹⸍ᶜⁱᵖ¹. This suggests that p21ʷᵃᶠ¹⸍ᶜⁱᵖ¹ functions downstream of these oncogenes, suggesting that mitogenic signals converge at the cyclin/cdk complex. To address the interplay between positive and negative signals within the cell cycle machinery, we used this system to test the effects of overexpressing both p21ʷᵃᶠ¹⸍ᶜⁱᵖ¹ and E2F1, a subunit of the E2F transcription factor, on the growth of CEF. The E2F transcription factors are released from binding to hypophosphorylated pRb when pRb is phosphorylated by cyclin/cdks. This allows for transcription of S phase genes and progression from G₁ to S phase in the cell cycle. In this system very high levels of E2F1 overexpression cause considerable apoptosis, however the surviving cells still overexpress E2F1. These cells are transformed and their growth is blocked by overexpression of p21ʷᵃᶠ¹⸍ᶜⁱᵖ¹. These data suggest that p21ʷᵃᶠ¹⸍ᶜⁱᵖ¹ might be useful for gene therapy for human cancer. We also show that the apoptosis induced by high levels of E2F1 can be blocked by Bc1-2, an inhibitor of apoptosis.
LA COMUNICAZIONE VISIVA NELLA DIVULGAZIONE MICROBIOLOGICA
Creators: name: Fonseca, Max
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2024

description: Inserendosi nell’ambito della comunicazione scientifica, il presente progetto di tesi mira ad esplorare e sviluppare strategie visive atte a divulgare le conoscenze microbiologiche alla società. Contestualizzando lo sviluppo progettuale all’interno della mostra scientifica relativa alle ricerche biologiche sul Lago di Cadagno e la Val Piora, il progetto “La comunicazione visiva nella divulgazione microbiologica” si rivolge ad un pubblico molto ampio formato dai potenziali visitatori del contesto espositivo. Attraverso un marcato coinvolgimento dell’utente sia dal punto di vista emotivo che da quello interattivo, l’obiettivo generale è quello di stupire ed informare il pubblico sulle scienze microbiologiche, al fine di accrescere la consapevolezza collettiva sull’importanza dei microrganismi per la salute dell’ecosistema globale.
sj-pdf-1-ome-10.1177_0030222820947224 - Supplemental material for Assessment of the Psychometric Properties of the Persian Version of the Cardiac Self-Blame Attribution (CSBA-P) Scale in Patients With Cardiovascular Disease
Creators: name: Goudarzian, Amir Hossein
name: Sharif Nia, Hamid
name: Harry, Kadie M.
name: Jannati, Yadollah
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, sj-pdf-1-ome-10.1177_0030222820947224 for Assessment of the Psychometric Properties of the Persian Version of the Cardiac Self-Blame Attribution (CSBA-P) Scale in Patients With Cardiovascular Disease by Amir Hossein Goudarzian, Hamid Sharif Nia, Kadie M. Harry and Yadollah Jannati in OMEGA-Journal of Death and Dying