cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Dynamic Phase Transitions in Cell Spreading
Creators: name: Doebereiner, H. -G.
name: Dubin-Thaler, B. J.
name: Giannone, G.
name: Xenias, H. S.
name: Sheetz, M. P.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Cell Behavior (q-bio.CB)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: We monitored isotropic spreading of mouse embryonic fibroblasts on fibronectin-coated substrates. Cell adhesion area versus time was measured via total internal reflection fluorescence microscopy. Spreading proceeds in well-defined phases. We found a power-law area growth with distinct exponents a_i in three sequential phases, which we denote basal (a_1=0.4+-0.2), continous (a_2=1.6+-0.9) and contractile (a_3=0.3+-0.2) spreading. High resolution differential interference contrast microscopy was used to characterize local membrane dynamics at the spreading front. Fourier power spectra of membrane velocity reveal the sudden development of periodic membrane retractions at the transition from continous to contractile spreading. We propose that the classification of cell spreading into phases with distinct functional characteristics and protein activity patterns serves as a paradigm for a general program of a phase classification of cellular phenotype. Biological variability is drastically reduced when only the corresponding phases are used for comparison across species/different cell lines.
description: 4 pages, 5 figures
Destination Prediction Based on Partial Trajectory Data - Hyperparameters
Creators: name: Ebel, Patrick
Publisher: name: figshare
Year: 2020
Subjects: subject: 170203 Knowledge Representation and Machine Learning
subject: FOS: Psychology

description: This table presents the hyperparameters retrieved after hyperparamter optimization and used to test the final models in "Destination Prediction Based on Partial Trajectory Data"
II. Meşrutiyet'ten I. Dünya Savaşı'na Osmanlı Bahriyesine Dair Notlar
Creators: name: Özel, Sabahattin
name: Kocatürk, Önder
Publisher: name: figshare
Year: 2020
Subjects: History

description: Tarih Dergisi (ISSN: 1015-1818) (46), 205-271 (Date: June 2009)
Measurement of the permanent electric dipole moment of the neutron
Creators: name: Abel, C.
name: Afach, S.
name: Ayres, N. J.
name: Baker, C. A.
name: Ban, G.
name: Bison, G.
name: Bodek, K.
name: Bondar, V.
name: Burghoff, M.
name: Chanel, E.
name: Chowdhuri, Z.
name: Chiu, P. -J.
name: Clement, B.
name: Crawford, C. B.
name: Daum, M.
name: Emmenegger, S.
name: Ferraris-Bouchez, L.
name: Fertl, M.
name: Flaux, P.
name: Franke, B.
name: Fratangelo, A.
name: Geltenbort, P.
name: Green, K.
name: Griffith, W. C.
name: van der Grinten, M.
name: Grujić, Z. D.
name: Harris, P. G.
name: Hayen, L.
name: Heil, W.
name: Henneck, R.
name: Hélaine, V.
name: Hild, N.
name: Hodge, Z.
name: Horras, M.
name: Iaydjiev, P.
name: Ivanov, S. N.
name: Kasprzak, M.
name: Kermaidic, Y.
name: Kirch, K.
name: Knecht, A.
name: Knowles, P.
name: Koch, H. -C.
name: Koss, P. A.
name: Komposch, S.
name: Kozela, A.
name: Kraft, A.
name: Krempel, J.
name: Kuźniak, M.
name: Lauss, B.
name: Lefort, T.
name: Lemière, Y.
name: Leredde, A.
name: Mohanmurthy, P.
name: Mtchedlishvili, A.
name: Musgrave, M.
name: Naviliat-Cuncic, O.
name: Pais, D.
name: Piegsa, F. M.
name: Pierre, E.
name: Pignol, G.
name: Plonka-Spehr, C.
name: Prashanth, P. N.
name: Quéméner, G.
name: Rawlik, M.
name: Rebreyend, D.
name: Rienäcker, I.
name: Ries, D.
name: Roccia, S.
name: Rogel, G.
name: Rozpedzik, D.
name: Schnabel, A.
name: Schmidt-Wellenburg, P.
name: Severijns, N.
name: Shiers, D.
name: Dinani, R. Tavakoli
name: Thorne, J. A.
name: Virot, R.
name: Voigt, J.
name: Weis, A.
name: Wursten, E.
name: Wyszynski, G.
name: Zejma, J.
name: Zenner, J.
name: Zsigmond, G.
Publisher: name: arXiv
Year: 2020
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Experiment (nucl-ex)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: We present the result of an experiment to measure the electric dipole moment (EDM) of the neutron at the Paul Scherrer Institute using Ramsey's method of separated oscillating magnetic fields with ultracold neutrons (UCN). Our measurement stands in the long history of EDM experiments probing physics violating time reversal invariance. The salient features of this experiment were the use of a Hg-199 co-magnetometer and an array of optically pumped cesium vapor magnetometers to cancel and correct for magnetic field changes. The statistical analysis was performed on blinded datasets by two separate groups while the estimation of systematic effects profited from an unprecedented knowledge of the magnetic field. The measured value of the neutron EDM is $d_{\rm n} = (0.0\pm1.1_{\rm stat}\pm0.2_{\rm sys})\times10^{-26}e\,{\rm cm}$.
description: 5 pages, 4 figures, submitted to PRL on 18.12.2019
Non-Gaussianities in models with a varying inflaton decay rate
Creators: name: Zaldarriaga, Matias
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We consider the expected level of primordial non-Gaussianities in models in which density perturbations are produced by spatial fluctuations in the decay rate of the inflaton. We consider both the non-Gaussianities resulting from the self-couplings of the field that controls the decay rate as well as from the non-linear relation between field and curvature perturbations. We show that in these scenario non-Gaussianities are of the "local" form, that is well described be the ansatz R =Rg + f_{NL} (Rg^2 - ). This is a consequence of the fact that they were created when modes were already outside the horizon. We show that f_{NL} is naturally of order a few in these models, much larger than what is expected in the standard one field models of inflation (f_{NL}\sim 10^{-2}) and possibly accessible to observations.
Tinna Dohrn 1859
Creators: name: Fent, Meral
name: Dursun, Ahmet
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Reduviidae
Tinna

description: Genus Tinna Dohrn, 1859
 Type species: Emesa gracilis Stål, 1855, by monotypy.
description: Published as part of Fent, Meral & Dursun, Ahmet, 2021, A new species of Tinna (Hemiptera: Heteroptera: Reduviidae) from Nigeria, pp. 193-199 in Zootaxa 5004 (1) on page 193, DOI: 10.11646/zootaxa.5004.1.9, http://zenodo.org/record/5120574
title: Does Guaranteed Income Build Assets for Black Women? Evidence from the In Her Hands Program
Creators: name: Roll, Stephen
name: Elliott, Desha
name: Smith, Simone
name: Quick, Aaron
name: Brugger, Laura
name: Davis, Shadonna
name: Hamilton, Leah
Publisher: name: University of Michigan
Year: 2024
Subjects: subject: Guaranteed Income
subject: Unconditional Cash Transfers
subject: Poverty
subject: Social Work
subject: FOS: Sociology
subject: Social Sciences

description: The goal of the Financial Independence policy conference held on September 16 and 17, 2024 in Washington, D.C. was to bring together experts from the asset and income fields to share theory, evidence, and best practices. The conference was divided into four sessions. The first two sessions were on Children’s Savings Accounts and Baby Bonds, the asset arm of the conference. The third session focused on the income arm. More specifically, it focused on Unconditional Cash Transfers, the Child Tax Credit, and Child Allowances. The final session focused on why solving poverty requires both asset and income proponents to come together. This policy brief is part of the coming together session.
description: This study provides evidence that guaranteed income programs like In Her Hands—which focuses on women living in majority-Black and high-poverty Georgia neighborhoods—are providing families with a diverse array of financial benefits, which may be attributable in part to the agency and flexibility offered through cash support. Families are using the payments to catch up on their bills, improve their debt situations, build their short-term savings, and even start saving for long-term goals that are important factors in emerging from intergenerational cycles of poverty, such as paying for higher education for themselves or their children.
On the Status of Highly Entropic Objects
Creators: name: Marolf, Donald
name: Sorkin, Rafael
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: It has been proposed that the entropy of any object must satisfy fundamental (holographic or Bekenstein) bounds set by the object's size and perhaps its energy. However, most discussions of these bounds have ignored the possibility that objects violating the putative bounds could themselves become important components of Hawking radiation. We show that this possibility cannot a priori be neglected in existing derivations of the bounds. Thus this effect could potentially invalidate these derivations; but it might also lead to observational evidence for the bounds themselves.
description: 6 pages, RevTex, a few editorial changes
Additional file 1 of Application of associating liver partition and portal vein ligation for staged hepatectomy for initially unresectable hepatocellular carcinoma
Creators: name: Chen, Haoqi
name: Wang, Xiaowen
name: Zhu, Wenfeng
name: Li, Yang
name: Yu, Zhenyu
name: Li, Hua
name: Yang, Yang
name: Zhu, Shuguang
name: Chen, Xiaolong
name: Wang, Genshu
Publisher: name: figshare
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1. Supplementary Figure.
Strong Universality in Forced and Decaying Turbulence
Creators: name: L'vov, Victor S.
name: Pasmanter, Ruben
name: Pomyalov, Anna
name: Procaccia, Itamar
Publisher: name: arXiv
Year: 2003
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: The weak version of universality in turbulence refers to the independence of the scaling exponents of the $n$th order strcuture functions from the statistics of the forcing. The strong version includes universality of the coefficients of the structure functions in the isotropic sector, once normalized by the mean energy flux. We demonstrate that shell models of turbulence exhibit strong universality for both forced and decaying turbulence. The exponents {\em and} the normalized coefficients are time independent in decaying turbulence, forcing independent in forced turbulence, and equal for decaying and forced turbulence. We conjecture that this is also the case for Navier-Stokes turbulence.
description: RevTex 4, 10 pages, 5 Figures (included), 1 Table; PRE, submitted
QCD spin physics: status, and prospects for RHIC
Creators: name: Vogelsang, Werner
Publisher: name: arXiv
Year: 2004
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We review some of the recent developments in QCD spin physics and highlight the spin program now underway at RHIC.
description: 16 pages LaTeX, 14 figures. Invited talk presented at the ``Workshop on High Energy Physics Phenomenology (WHEPP-8)'', Indian Institute of Technology, Mumbai, January 5-16, 2004
Wie wir Kindern den Krieg erklären : implizite Logiken in Erklärvideos für Kinder aus erziehungswissenschaftlicher Sicht
Creators: name: Bauer, Angela
name: Stoeck, Janine
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 370

description: Erklärvideos für Kinder und Jugendliche werden in den letzten Jahren zunehmend relevanter. Im Zuge von Mediatisierung und Digitalisierung verbreiterte sich das Angebot an Erklärvideos für spezifische Adressat:innengruppen. Erklärvideos nahmen in diesem Zuge auch im Rahmen von Bildungs- und Aneignungsprozessen in der (schulischen) Lebenswelt von Kindern und Jugendlichen einen festen Platz ein (MPFS 2022, 36f.). Bislang ist noch offen, welcher Logik diese Angebote folgen und wie sie sich als Forschungsgegenstand konstituieren. Der vorliegende Beitrag knüpft hier an und widmet sich aus einer erziehungswissenschaftlichen Perspektive den pädagogischen Implikationen. Entlang der Analyse erster Befunde einer explorativ-empirischen Studie zu krisenbezogenen Erklärvideos zum Ukraine-Krieg, in der ausgewählte Text- und Bildelemente exemplarisch nach der Objektiven Hermeneutik interpretiert wurden, wird vorgestellt, was in diesen Videos implizit zum Ausdruck gebracht wird. Mit Blick auf den Bedeutungszusammenhang für die Rezipient:innen lässt sich überlegen, welchen Spielraum die herausgestellten Inszenierungen von Erklärungen für die Selbsterprobung und Weltdeutung (Bildung eines Selbst- und Weltverhältnisses) von Kindern bereitstellen und welche Antwort sie auf Krisenphänomene geben.
A study of the appearance of tau neutrinos from a gamma ray burst by detecting their horizontal electromagnetic showers
Creators: name: Gupta, Nayantara
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We explore the possibilty of detecting horizontal electromagnetic showers of tau neutrinos from individual gamma ray bursts, in large scale detectors like HiRes and Telescope Array. We study the role of the parameters of a gamma ray burst in determining the expected number of tau events from that burst. The horizontal beam of tau leptons produce visible signals in the atmosphere. We find that there is a slim chance of observing tau lepton appearances from GRBs with Telescope Array. The number of signals is strongly dependent on the Lorentz factor $Γ$, redshift $z$ of a GRB, energy emitted in muon neutrinos and antineutrinos $E_{ν,HE}$ and also on some other parameters of a GRB. It is possible to understand neutrino oscillations in astrophysical neutrinos and the mechanism or model of neutrino production inside a GRB by detection or non detection of tau lepton signals from it.
description: 22 pages, 7 figures, minor changes made in the text
Neopetrosia sulcata Santos, Sandes, Cabral & Pinheiro 2016
Creators: name: Rocha, Lívia
name: Moraes, Fernando
name: Salani, Sula
name: Hajdu, Eduardo
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Porifera
Demospongiae
Haplosclerida
Petrosiidae
Neopetrosia
Neopetrosia sulcata

description: Neopetrosia sulcata Santos, Sandes, Cabral & Pinheiro, 2016
 Holotype (not examined). Brazil, Rio Grande do Norte State, UFPEPOR 17, Potiguar Basin (4.62547º S, 36.76686º W), 70–101 m depth, leg. Petrobras, 2003.5.4.
 Diagnosis. Irregularly cylindrical fragments. Surface punctiform or furrowed, rugose to the touch, with scattered circular oscules (1.5–10 mm diam.), always flush with the surface. Consistency hard, slightly brittle. Ectosome formed by tangential multispicular tracts (50–250 μm diam.), with rounded meshes (150–300 μm diam.), and the apical brushes of oxeas from longitudinal choanosomal spicule tracts. Choanosomal skeleton isotropic, with a superimposed anisotropic orientation of multispicular tracts and single spicules strewn in confusion. Oxeas smooth, relatively robust, usually curved, with fairly high percentage of variations at the ends (mucronate, stepped, hastate, asymmetrical, or blunt), 119–193 x 2.8– 9.6 μm [adapted from Santos et al. 2016].
 Description. Refer to Santos et al. (2016).
 Distribution. Tropical Atlantic. Brazil: Maranhão State (Campos et al. 2005, as N. proxima); Potiguar Basin, Rio Grande do Norte State (Santos et al. 2016).
description: Published as part of Rocha, Lívia, Moraes, Fernando, Salani, Sula & Hajdu, Eduardo, 2021, Taxonomy of Petrosiidae Van Soest, 1980 (Haplosclerida, Porifera) from Brazil, pp. 251-287 in Zootaxa 5004 (2) on page 262, DOI: 10.11646/zootaxa.5004.2.2, http://zenodo.org/record/5677189
Solitary Wave Dynamics in an External Potential
Creators: name: Frohlich, J.
name: Gustafson, S.
name: Jonsson, B. L. G.
name: Sigal, I. M.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Mathematical Physics (math-ph)
subject: Analysis of PDEs (math.AP)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 35Q55;37K40;37K05;70K40

description: We study the behavior of solitary-wave solutions of some generalized nonlinear Schrödinger equations with an external potential. The equations have the feature that in the absence of the external potential, they have solutions describing inertial motions of stable solitary waves. We construct solutions of the equations with a non-vanishing external potential corresponding to initial conditions close to one of these solitary wave solutions and show that, over a large interval of time, they describe a solitary wave whose center of mass motion is a solution of Newton's equations of motion for a point particle in the given external potential, up to small corrections corresponding to radiation damping.
description: latex2e, 41 pages, 1 figure
Optimal Controller Synthesis and Dynamic Quantizer Switching for Linear-Quadratic-Gaussian Systems
Creators: name: Maity, Dipankar
name: Tsiotras, Panagiotis
Publisher: name: arXiv
Year: 2020
Subjects: subject: Systems and Control (eess.SY)
subject: Dynamical Systems (math.DS)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Mathematics

description: In networked control systems, often the sensory signals are quantized before being transmitted to the controller. Consequently, performance is affected by the coarseness of this quantization process. Modern communication technologies allow users to obtain resolution-varying quantized measurements based on the prices paid. In this paper, we consider optimal controller synthesis of a Quantized-Feedback Linear-Quadratic-Gaussian (QF-LQG) system where the measurements are to be quantized before being transmitted to the controller. The system is presented with several choices of quantizers, along with the cost of operating each quantizer. The objective is to jointly select the quantizers and the controller that would maintain an optimal balance between control performance and quantization cost. Under certain assumptions, this problem can be decoupled into two optimization problems: one for optimal controller synthesis and the other for optimal quantizer selection. We show that, similarly to the classical LQG problem, the optimal controller synthesis subproblem is characterized by Riccati equations. On the other hand, the optimal quantizer selection policy is found by solving a certain Markov-Decision-Process (MDP).
title: Endangered Species Act Section 7(a)(2) Biological Opinion and Magnuson-Stevens Fishery Conservation and Management Act Essential Fish Habitat Response for the Jelly’s Ferry Bridge Replacement Project Reinitiation 2020.
Creators: name: United States. National Marine Fisheries Service. West Coast Region
Publisher: name: United States. National Marine Fisheries Service. West Coast Region
Year: 2021

description: ESA Section 7 Consultation ; WCRO-2020-01879
Assessing the potential cost-effectiveness of a gene therapy for the treatment of hemophilia A
Creators: name: Keziah Cook
name: Forbes, Shaun P.
name: Adamski, Kelly
name: Ma, Janice J.
name: Chawla, Anita
name: Garrison, Louis P.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Ecology
subject: Science Policy

description: Aim: Hemophilia A is a genetic, chronic disorder classified by deficient or defective coagulation factor VIII (FVIII) that puts those affected at risk for spontaneous bleeding episodes, which lead to joint damage and chronic pain over time. Currently, most severe hemophilia A patients are treated with prophylactic FVIII, which requires costly and frequent infusions and life-long adherence to medication. A gene therapy (valoctocogene roxaparvovec) is currently in development for the treatment of severe hemophilia A. This model assessed the potential cost-effectiveness of treating patients with valoctocogene roxaparvovec rather than prophylactic therapy. Materials and methods: We developed an individual-based, state-transition microsimulation model for assessing the likely cost-effectiveness of valoctocogene roxaparvovec compared to prophylactic FVIII. Men aged 30 with severe hemophilia A were modeled over a lifetime horizon, and costs were reported from the perspective of the United States health care system. Through microsimulation, patient-level heterogeneity was captured in starting weight, starting Pettersson score (PS), durability of valoctocogene roxaparvovec, and annual bleed rate (ABR). Results: The model projects that treatment with single-administration valoctocogene roxaparvovec would be cost-saving to people with hemophilia A at a price point comparable to other currently available gene therapy products due to its potential to reduce FVIII utilization, direct medical costs, lifetime bleeds, and accumulated joint damage. Limitations: The model relies upon evidence-based assumptions for clinical inputs due to limited data availability. Such uncertainty was mitigated by modeling heterogeneity across the population, specifically with regards to long-term gene therapy durability, lifetime bleed rates, and joint damage progression. Conclusion: Valoctocogene roxaparvovec was found to be cost-saving—on average by about $6.8 million per patient—and more effective than prophylactic therapy for treatment of hemophilia A. The comparative benefit of gene therapy was observed across a broad range of simulated patients that were representative of the real-world severe hemophilia A population.
Changes in reproduction mediate the effects of climate change and grassland management on plant population dynamics
Creators: name: Andrzejak, Martin
name: Knight, Tiffany M.
name: Plos, Carolin
name: Korell, Lotte
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2025
Subjects: subject: 580

description: Climate change is one of the largest threats to grassland plant species, which can be modified by land management. Although climate change and land management are expected to separately and interactively influence plant demography, this has been rarely considered in climate change experiments. We used a large-scale experiment in central Germany to quantify the effects of grassland management, climate change, and their joint effect on the demography and population growth rate of 11 plant species all native to this temperate grassland ecosystem. We parameterized integral projection models with five years of demographic data to project population growth rate. We hypothesized that plant populations perform better in the ambient than in the future climate treatment that creates hotter and drier summer conditions. Further, we hypothesized that plant performance interactively responds to climate and land management in a species-specific manner based on the drought, mowing, and grazing tolerances as well as the flowering phenology of each species. Due to extreme drought events, over half of our study species went quasi extinct, which highlights how extreme climate events can influence long-term experimental results. We found no consistent support for our expectation that plants perform better in ambient compared with future climate conditions. However, several species showed interactive responses to the treatments, indicating that optimal management strategies for plant performance are expected to shift with climate change. Changes in population growth rates of these species across treatments were mostly due to changes in plant reproduction. Experiments combined with measuring plant demographic responses provide a way to isolate the effects of different drivers on the long-term persistence of species and to identify the demographic vital rates that are critical to manage in the future. Our study suggests that it will become increasingly difficult to maintain species with preferences for moister soil conditions, and that climate and land use can interactively alter demographic responses of the remaining grassland species.
Assessing the potential cost-effectiveness of a gene therapy for the treatment of hemophilia A
Creators: name: Keziah Cook
name: Forbes, Shaun P.
name: Adamski, Kelly
name: Ma, Janice J.
name: Chawla, Anita
name: Garrison, Louis P.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Ecology
subject: Science Policy

description: Aims: Hemophilia A is a genetic, chronic disorder classified by deficient or defective coagulation factor VIII (FVIII) that puts those affected at risk for spontaneous bleeding episodes, which lead to joint damage and chronic pain over time. Currently, most severe hemophilia A patients are treated with prophylactic FVIII, which requires costly and frequent infusions and life-long adherence to medication. A gene therapy (valoctocogene roxaparvovec) is currently in development for the treatment of severe hemophilia A. This model assessed the potential cost-effectiveness of treating patients with valoctocogene roxaparvovec rather than prophylactic therapy. Materials and methods: We developed an individual-based, state-transition microsimulation model for assessing the likely cost-effectiveness of valoctocogene roxaparvovec compared to prophylactic FVIII. Men aged 30 with severe hemophilia A were modeled over a lifetime horizon, and costs were reported from the perspective of the United States health care system. Through microsimulation, patient-level heterogeneity was captured in starting weight, starting Pettersson score (PS), durability of valoctocogene roxaparvovec, and annual bleed rate (ABR). Results: The model projects that treatment with single-administration valoctocogene roxaparvovec would be cost-saving to people with hemophilia A at a price point comparable to other currently available gene therapy products due to its potential to reduce FVIII utilization, direct medical costs, lifetime bleeds, and accumulated joint damage. Limitations: The model relies upon evidence-based assumptions for clinical inputs due to limited data availability. Such uncertainty was mitigated by modeling heterogeneity across the population, specifically with regard to long-term gene therapy durability, lifetime bleed rates, and joint damage progression. Conclusions: Valoctocogene roxaparvovec was found to be cost-saving—on average by about $6.8 million per patient—and more effective than prophylactic therapy for treatment of hemophilia A. The comparative benefit of gene therapy was observed across a broad range of simulated patients that were representative of the real-world severe hemophilia A population.
Additional file 1 of Randomized phase II study of daily and alternate-day administration of S-1 for adjuvant chemotherapy in completely-resected stage I non-small cell lung cancer: results of the Setouchi Lung Cancer Group Study 1301
Creators: name: Okumura, Norihito
name: Soh, Junichi
name: Suzuki, Hiroyuki
name: Nakata, Masao
name: Fujiwara, Toshiya
name: Hiroshige Nakamura
name: Sonobe, Makoto
name: Fujinaga, Takuji
name: Kataoka, Kazuhiko
name: Gemba, Kenichi
name: Kataoka, Masafumi
name: Hotta, Katsuyuki
name: Hiroshige Yoshioka
name: Keitaro Matsuo
name: Sakamoto, Junichi
name: Date, Hiroshi
name: Toyooka, Shinichi
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: Additional file 1. Online Resource 1. The exclusion criteria.
Drug-dependent inhibitory effects on corneal epithelium structure, cell viability, and corneal wound healing by local anesthetics
Creators: name: Foja, Sabine
name: Heinzelmann, Joana
name: Hünniger, Susanne
name: Viestenz, Anja
name: Rüger, Christiane
name: Viestenz, Arne
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 610

description: Local anesthetics are commonly used in ophthalmic surgery. However, their use can affect the healing process. This study aimed to investigate the potential impact of anesthetic substances at clinically relevant concentrations and incubation times (3 min), specifically oxybuprocaine (OBPC, 0.4%), lidocaine (LIDO, 2%), and bupivacaine (BUPI, 0.5%), either alone or supplemented with hylase (HYLA, 30 I.E.), on corneal epithelium structure, cell viability, and wound healing. To assess the potential cytotoxicity of these anesthetic substances, viability and colony-forming efficiency (CFE) assays were conducted using the human telomerase-immortalized corneal epithelial (hTCEpi) cell line. Additionally, the toxicity of these substances was evaluated using a 3D human tissue-specific corneal epithelial construct as well as a porcine corneal culture model. The results indicate that OBPC (Novesine® 0.4%) exhibited significant cytotoxicity in 2D and 3D corneal epithelial cell culture models and delayed wound healing in the ex vivo porcine corneal organ culture model. In contrast, LIDO, BUPI, and HYLA were less cytotoxic to corneal cells, with no observed impact on wound healing in the porcine corneal organ culture model. In summary, local anesthetics commonly used in eye surgery are generally considered safe. However, the application of OBPC (Novesine® 0.4%) may delay wound healing.
Non-local Interaction Effects on Pattern Formation in Population Dynamics
Creators: name: Fuentes, M. A.
name: Kuperman, M. N.
name: Kenkre, V. M.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Pattern Formation and Solitons (nlin.PS)
subject: Quantitative Biology (q-bio)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: We consider a model for population dynamics such as for the evolution of bacterial colonies which is of the Fisher type but where the competitive interaction among individuals is non-local, and show that spatial structures with interesting features emerge. These features depend on the nature of the competitive interaction as well as on its range, specifically on the presence or absence of tails in, and the central curvature of, the influence function of the interaction.
description: 4 Pages, 6 Figures included
title: Endangered Species Act (ESA) Section 7(a)(2) Biological Opinion and Magnuson-Stevens Fishery Conservation and Management Act Essential Fish Habitat Response Agency Approval of and Participation in the Port of Tacoma Clear Creek Multi-Resource Mitigation Bank
Creators: name: United States. National Marine Fisheries Service. West Coast Region
Publisher: name: United States. National Marine Fisheries Service. West Coast Region
Year: 2020

description: ESA Section 7 Consultation ; WCRO-2020-00550
The MASSIVE Survey -- XV. A Stellar Dynamical Mass Measurement of the Supermassive Black Hole in Massive Elliptical Galaxy NGC 1453
Creators: name: Liepold, Christopher M.
name: Quenneville, Matthew E.
name: Ma, Chung-Pei
name: Walsh, Jonelle L.
name: McConnell, Nicholas J.
name: Greene, Jenny E.
name: Blakeslee, John P.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present a new stellar dynamical mass measurement ($M_\mathrm{BH}$) of the supermassive black hole (SMBH) in NGC 1453, a fast-rotating massive elliptical galaxy in the MASSIVE survey. We measure stellar kinematics in 135 spatial bins in the central 1.5 kpc by 2 kpc region of the galaxy using high signal-to-noise ($S/N \sim 130$) spectra from the Gemini-North GMOS integral-field spectrograph (IFS). Combining with wide-field IFS kinematics out to $\sim 3$ effective radii and stellar light distributions from Hubble Space Telescope (HST) WFC3 images, we perform Schwarzschild orbit-based mass modeling in the axisymmetric limit to constrain the mass components in NGC 1453. The best-fit black hole mass is $M_\mathrm{BH} =(2.9 \pm 0.4) 10^9 M_\odot$; the mass models without a central black hole are excluded at the $8.7σ$ level. The NGC 1453 black hole lies within the intrinsic scatter of the SMBH and galaxy scaling relations, unlike three other galaxies hosting $\gtrsim 10^{10} M_\odot$ SMBHs in the MASSIVE sample. The high-$S/N$ GMOS spectra enable us to determine 8 moments of the Gauss-Hermite expansion of the line-of-sight velocity distributions (LOSVDs), which are used as constraints in the orbit modeling. The stellar orbits in the mass models are further constrained to produce negligible $h_9$ through $h_{12}$ to minimize spurious behavior in the LOSVDs. We show that truncating the series at $h_4$, as was often done in prior work, leads to a much weaker constraint on the inferred $M_\mathrm{BH}$ for NGC 1453. Furthermore, we discuss precautions and modifications that are needed to achieve axisymmetry in triaxial orbit codes that use the Schwarzschild method to sample the start space of stellar orbits in triaxial gravitational potentials.
description: Accepted for publication in The Astrophysical Journal. 22 pages, 12 figures; References updated
Effects of J-gate potential and interfaces on donor exchange coupling in the Kane quantum computer architecture
Creators: name: Kettle, L. M.
name: Goan, H. -S.
name: Smith, Sean C.
name: Hollenberg, L. C. L.
name: Wellard, C. J.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We calculate the electron exchange coupling for a phosphorus donor pair in silicon perturbed by a J-gate potential and the boundary effects of the silicon host geometry. In addition to the electron-electron exchange interaction we also calculate the contact hyperfine interaction between the donor nucleus and electron as a function of the varying experimental conditions. Donor separation, depth of the P nuclei below the silicon oxide layer and J-gate voltage become decisive factors in determining the strength of both the exchange coupling and the hyperfine interaction - both crucial components for qubit operations in the Kane quantum computer. These calculations were performed using an anisotropic effective-mass Hamiltonian approach. The behaviour of the donor exchange coupling as a function of the device parameters varied provides relevant information for the experimental design of these devices.
description: 15 pages, 15 figures. Accepted for Journal of Physics: Condensed Matter
Pseudanisakis Layman & Borovkova 1926
Creators: name: Arai, Hisao P.
name: Smith, John W.
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Nematoda
Chromadorea
Spirurida
Anisakidae
Pseudanisakis

description: Pseudanisakis Layman & Borovkova, 1926
Synonyms: Eustoma van Beneden, 1871; Anacanthocheilus Wülker, 1930; Pseudanisakis Yamaguti, 1941; Metanisakis Mozgovoi, 1950
Generic diagnosis (after Gibson 1973). Acanthocheilidae. One dorsal lip and two subventral lips (Fig. 72 A), each with two papillae. Interlabia absent. Amphid present on subventral lips. Oesophagus long and narrow. Ventriculus oval or oblong, not round (Fig. 72 B). Ventricular appendix and intestinal caecum absent. Excretory pore just posterior to nerve ring. Anal glands absent. Male tail conical; normally six to nine pre-cloacal papillae on each side with five ad-cloacal or post-cloacal pairs of papillae. Spicules equal. Ejaculatory duct distinct and glandular; gubernaculum absent (Fig. 72 C). Male P. tricupola from Amblyraja radiata 5.9–57.0 long. Female tail tapers to sharp point (Fig. 72 D). Vulva situated in anterior half of body posterior to the ventriculus. Female P. tricupola from A. radiata are 5.9–34.5 long. Parasites of rays.
description: Published as part of Arai, Hisao P. & Smith, John W., 2016, Guide to the Parasites of Fishes of Canada Part V: Nematoda, pp. 1-274 in Zootaxa 4185 (1) on page 119, DOI: 10.11646/zootaxa.4185.1.1, http://zenodo.org/record/165530
Spontaneous Rotational Symmetry Breaking in a Kramers Two-Level System
Creators: name: Silveirinha, Mario G.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Optics (physics.optics)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Here, I develop a model for a two-level system that respects the time-reversal symmetry of the atom Hamiltonian and the Kramers theorem. The two-level system is formed by two Kramers pairs of excited and ground states. It is shown that due to the spin-orbit interaction it is in general impossible to find a basis of atomic states for which the crossed transition dipole moment vanishes. The parametric electric polarizability of the Kramers two-level system for a definite ground-state is generically nonreciprocal. I apply the developed formalism to study Casimir-Polder forces and torques when the two-level system is placed nearby either a reciprocal or a nonreciprocal substrate. In particular, I investigate the stable equilibrium orientation of the two-level system when both the atom and the reciprocal substrate have symmetry of revolution about some axis. Surprisingly, it is found that when chiral-type dipole transitions are dominant the stable ground state is not the one in which the symmetry axes of the atom and substrate are aligned. The reason is that the rotational symmetry may be spontaneously broken by the quantum vacuum fluctuations, so that the ground state has less symmetry than the system itself.
description: to appear in Phys. Rev. B (in press)
Supplemental Material.S4.pdf
Creators: name: Land, Stephen
name: Booth, David
Publisher: name: figshare
Year: 2020
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: 119999 Medical and Health Sciences not elsewhere classified
subject: FOS: Other medical sciences

description: Data table and list of references used for the meta-analysis
X-ray Modeling of Very Young Early Type Stars in the Orion Trapezium: Signatures of Magnetically Confined Plasmas and Evolutionary Implications
Creators: name: Schulz, Norbert S.
name: Canizares, Claude R.
name: Huenemoerder, Dave P.
name: Tibbetts, Kevin J.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We analyzed high resolution X-ray spectra in the wavelength range of 1.5 -- 25 A of three of its X-ray brightest members obtained with the High Energy Transmission Grating Spectrometer (HETGS) on-board the Chandra X-ray Observatory. The DEM derived from over 80 emission lines in the spectrum of Theta Ori C indicates three peaks located at 7.9 MK, 25 MK, and 66 MK. The emission measure varies over the 15.4 day wind period of the star. For the two phases observed, the low temperature emission remains stable, while the high temperature emission shows significant differences. The line widths seem to show a similar bifurcation, where we resolve some of the soft X-ray lines with velocities up to 850 km/s, whereas the bulk of the lines remain unresolved. None of the lines are resolved for Theta Ori A and E. The high temperature emissivity contributes to most of the total X-ray flux in all stars. The bulk of the X-ray emission cannot be produced by shock instabilities in a radiation driven wind and are likely the result of magnetic confinement in all three stars. The fact that all stars appear to be magnetic and are near zero age on the main sequence also raises the issue whether the Orion stars are simply different or whether young massive stars enter the main sequence carrying significant magnetic fields.
description: 18 pages, 11 figures, accepted by ApJ
title: Endangered Species Act Section 7(a)(2) Biological Opinion, and Magnuson–Fishery Conservation and Management Act Essential Fish Habitat Response for the FEMA Clearwater Complex Post-Fire Mitigation Project, Idaho County, ID, HUC17060306
Creators: name: United States. National Marine Fisheries Service. West Coast Region
Publisher: name: United States. National Marine Fisheries Service. West Coast Region
Year: 2021

description: ESA Section 7 Consultation ; WCRO-2020-00523
Anemia in myelofibrosis : a focus on proactive management and the role of momelotinib
Creators: name: Al-Ali, Haifa Kathrin
name: Kuykendall, Andrew T.
name: Ellis, Catherine E.
name: Sampath, Janardhan
name: Mesa, Ruben A.
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 610

description: Background: Anemia is a common and progressive clinical manifestation of myelofibrosis that may occur as part of the disease pathogenesis as well as due to the myelosuppressive effects of some treatments, with a substantial impact on quality of life, prognosis, and healthcare resource utilization. Despite these burdens, anemia management has traditionally been a secondary priority to spleen and symptom control, due in part to the limitations of available therapeutic approaches. With the initial regulatory approvals of momelotinib, a Janus kinase 1 (JAK1), JAK2, and activin A receptor type 1 inhibitor that provides anemia-related benefits in addition to addressing splenomegaly and symptoms, re-evaluation of anemia as an early and prominent treatment consideration is warranted. Methods: In this review, we discuss the journey of patients with myelofibrosis and anemia across various severities and clinical scenarios. Results: Summarized are traditional approaches to anemia management and the clinical trial efficacy and safety data that support momelotinib as an option in each setting from mild to severe anemia, including in the context of co-occurring thrombocytopenia. Conclusions: With the availability of momelotinib and other emerging therapies directed at anemia control, early treatment of anemia to avoid progression and support improvement in eligible patients with myelofibrosis should be a primary consideration.
Closed dressing chains of D=1 and D=2 Toda lattice
Creators: name: Yurov, A. V.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences

description: We apply the method of dressing chains to reproduction of Toda lattice in the case of D=1 and D=2. On the example of modified equations $m_0TL$ and $m_1TL$ it is shown that combination of the Darboux and Schlesinger transformations results in closed dressing chains.
description: 15 pages
title: Endangered Species Act section 7(a)(2) Biological Opinion and Magnuson-Stevens Fishery Conservation and Management Act Essential Fish Habitat (EFH) Response Placer County Conservation Program Habitat Conservation Plan
Creators: name: United States. National Marine Fisheries Service. West Coast Region
Publisher: name: United States. National Marine Fisheries Service. West Coast Region
Year: 2021

description: ESA Section 7 Consultation ; WCRO-2020-03651
Electric field control of interfacial Dzyaloshinskii-Moriya interaction in Pt/Co/AlO$_x$ thin films
Creators: name: Schott, Marine
name: Ranno, Laurent
name: Béa, Hélène
name: Baraduc, Claire
name: Auffret, Stéphane
name: Bernand-Mantel, Anne
Publisher: name: arXiv
Year: 2020
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We studied electric field modification of magnetic properties in a Pt/Co/AlO$_x$ trilayer via magneto-optical Kerr microscopy. We observed the spontaneous formation of labyrinthine magnetic domain structure due to thermally activated domain nucleation and propagation under zero applied magnetic field. A variation of the period of the labyrinthine structure under electric field is observed as well as saturation magnetization and magnetic anisotropy variations. Using an analytical formula of the stripe equilibrium width we estimate the variation of the interfacial Dzyaloshinskii-Moriya interaction under electric field as function of the exchange stiffness constant.
title: Endangered Species Act Section 7(a)(2) Biological Opinion and Magnuson-Stevens Fishery Conservation and Management Act Essential Fish Habitat Response for the Tehama County Boat Ramps Project
Creators: name: United States. National Marine Fisheries Service. West Coast Region
Publisher: name: United States. National Marine Fisheries Service. West Coast Region
Year: 2021

description: ESA Section 7 Consultation ; WCRO-2020-02677
title: Endangered Species Act Section 7(a)(2) Biological Opinion for the Issuance of an ESA Section 10(a)(1)(A) Enhancement Permit to the United States Fish and Wildlife Service for Implementation of two Hatchery and Genetic Management Plans at Livingston Stone National Fish Hatchery
Creators: name: United States. National Marine Fisheries Service. West Coast Region
Publisher: name: United States. National Marine Fisheries Service. West Coast Region
Year: 2017

description: ESA Section 7 Consultation ; WCRO-2016-00302
Semantic integration demands modulate large-scale network interactions in the brain
Creators: name: Nieberlein, Laura
name: Martin, Sandra
name: Williams, Kathleen Anne
name: Gussew, Alexander
name: Cyriaks, Sophia D.
name: Scheer, Maximilian
name: Rampp, Stefan
name: Prell, Julian Konrad Theodor
name: Hartwigsen, Gesa
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 610

description: The ability to integrate semantic information into the context of a sentence is essential for human communication. Several studies have shown that the predictability of a final keyword based on the sentence context influences semantic integration on the behavioral, neurophysiological, and neural level. However, the architecture of the underlying network interactions for semantic integration across the lifespan remains unclear. In this study, 32 healthy participants (30–75 years) performed an auditory cloze probability task during functional magnetic resonance imaging (fMRI), requiring lexical decisions on the sentence's final words. Semantic integration demands were implicitly modulated by presenting sentences with expected, unexpected, anomalous, or pseudoword endings. To elucidate network interactions supporting semantic integration, we combined univariate task-based fMRI analyses with seed-based connectivity and between-network connectivity analyses. Behavioral data revealed typical semantic integration effects, with increased integration demands being associated with longer response latencies and reduced accuracy. Univariate results demonstrated increased left frontal and temporal brain activity for sentences with higher integration demands. Between-network interactions highlighted the role of task-positive and default mode networks for sentence processing with increased semantic integration demands. Furthermore, increasing integration demands led to a higher number of behaviorally relevant network interactions, suggesting that the increased between-network coupling becomes more relevant for successful task performance as integration demands increase. Our findings elucidate the complex network interactions underlying semantic integration across the aging continuum. Stronger interactions between various task-positive and default mode networks correlated with more efficient processing of sentences with increased semantic integration demands. These results may inform future studies with healthy old and clinical populations.
Symmetry Induced Heteroclinic Cycles in a CO2 Laser
Creators: name: Lopez-Ruiz, Ricardo
name: Boccaletti, Stefano
Publisher: name: arXiv
Year: 2003
Subjects: subject: Pattern Formation and Solitons (nlin.PS)
subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: FOS: Physical sciences

description: The conditions for the existence of heteroclinic connections between the transverse modes of a CO2 laser whose setup has a perfect cylindrical symmetry are discussed by symmetry arguments for the cases of three, four and five interacting modes. Explicit conditions for the parameters are derived, which can guide observation of such phenomena.
description: 15 pages, 0 figures