cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Loss of receptor activity-modifying protein 3 exacerbates cardiac hypertrophy and transition to heart failure in a sex-dependent manner
Creators: name: Caron, Kathleen M.
name: Dackor, Ryan T.
name: Lenhart, Patricia M.
name: Barrick, Cordelia J.
name: Nagle, Elizabeth
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Sex differences exist in the hypertrophic response, cardiac remodeling, and transition to heart failure of hypertensive patients, and while some of these differences are likely influenced by estrogen, the genetic pathways downstream of estrogen that impact on cardioprotection have yet to be fully elucidated. We have previously shown that the cardioprotective effects of adrenomedullin (AM), an emerging clinical biomarker for cardiovascular disease severity, vary with sex in mouse models. AM signaling during cardiovascular stress is strongly modulated by receptor activity-modifying protein 3 (RAMP3) via its interaction with the G protein-coupled receptor calcitonin receptor-like receptor (CLR). Like AM, RAMP3 expression is potently regulated by estrogen, and so we sought to determine the consequences of genetic Ramp3 loss on cardiac adaptation to chronic hypertension, with a particular focus on characterizing potential sex differences. We generated and bred RAMP3−/− mice to RenTgMK mice that consistently display severe angiotensin II-mediated CV disease and compared CV disease progression in RenTgMK to that of RenTgMK:RAMP3−/− offspring. As expected, RAMP3 gene expression was higher in cardiovascular tissues of RenTgMK mice and more strongly up-regulated in female RenTgMK mice relative to wildtype controls. RAMP3 loss did not affect the development of hypertension or the presence and severity of perivascular and interstitial fibrosis in the left ventricle (LV). However, echocardiography revealed that while RenTgMK mice developed concentric cardiac hypertrophy with sustained systolic function, male RenTgMK:RAMP3−/− mice showed evidence of LV chamber dilatation and depressed systolic function, suggestive of cardiac decompensation. Consistent with these measures of heart failure, male RenTgMK:RAMP3−/− mice had increased cardiac apoptosis and elevated activation of Akt. These phenotypes were not present in female RenTgMK:RAMP3−/− mice. Collectively, these data demonstrate a sex-dependant, cardioprotective role of RAMP3 in the setting of chronic hypertension.
title: Stellungnahme zur Institutionellen Reakkreditierung der Internationalen Hochschule SDI München
Creators: name: German Science And Humanities Council
Publisher: name: German Science and Humanities Council
Year: 2022
Subjects: Akkreditierung
Private Hochschulen
Qualitätssicherung
Hochschule SDI München
Hochschulförmigkeit
Reakkreditierung
Akkreditierungszeitraum 3 Jahre

description: Die Internationale Hochschule SDI München wird vom Wissenschaftsrat unter Auflagen für die Dauer von drei Jahren reakkreditiert. Sie ist eine Hochschule für angewandte Wissenschaften mit Bachelor- und Masterstudienangeboten in den Bereichen Übersetzen und Dolmetschen, interkulturelle Kommunikation, Wirtschaft, digitale Medien sowie Sprachdidaktik. Im Wintersemester 2021/2022 waren an der Hochschule hauptberufliche Professorinnen und Professoren im Umfang von rd. 14 Vollzeitäquivalenten (VZÄ) beschäftigt und rd. 300 Studierende eingeschrieben.
title: The brain in your belly....Neurological manifestations and spectrum of changes in the brain parenchyma in patients with liver cirrhosis
Creators: name: Laroia, Shalini
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Abdomen
subject: CNS
subject: Liver
subject: CT
subject: MR
subject: Imaging sequences
subject: Diagnostic procedure
subject: Metabolic disorders
subject: Toxicity

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To correlate the clinical neurological deficits in patients with chronic liver disease with their imaging findings To study the imaging spectrum and prevalence of neurological manifestations in this group of...
Role of the inflammasome in lung cancer Inflammasome is involved in lung carcinogenesis
Creators: name: Terlizzi, Michela
Publisher: name: Universita degli studi di Salerno
Year: 2017
Subjects: subject: BIO/14 FARMACOLOGIA
subject: Inflammosoma
subject: Carcinoma polmonare

description: 2014 - 2015
description: Lung cancer is recognized as one of the most devastating tumor worldwide due to the low rate survival over 5 years from the time of diagnosis. Inflammation has been widely recognized as the seventh hallmark of cancer as it facilitates the establishment/development and progression of lung cancer. In this context, recent evidence highlighted the role of the inflammasome during carcinogenesis. However, little is still known. The inflammasome is a multiprotein complex that leads to caspase-1 activation which role in lung cancer is still under investigated. In this context, the aim of my PhD project was to understand the role of the inflammasome in lung cancer in a mouse model of carcinogen-induced lung cancer and in human non-small cell lung cancer (NSCLC). We found that both caspase-1-dependent, the canonical pathway, and caspase-8/caspase-11-dependent, the non-canonical pathway, inflammasome were involved during lung cancer establishment and progression in both mice and humans. Our data showed that the pharmacological inhibition of both caspase-1 and caspase-8 significantly reduced lung tumor outgrowth associated to lower pro-inflammatory response and to a reduced lung recruitment of immunesuppressive cells and that caspase-8 was upstream caspase-1 activation during lung carcinogenesis. Furthermore, we showed that caspase-11 was the primary/main orchestrator of the inflammasome-dependent lung cancer progression and that the enzyme could be upstream of caspase-1 to induce the amplification of the occurring inflammatory process associated to lung cancer development. Finally, we identified a novel mechanism by which lung tumor-associated macrophages could favor lung tumorigenesis via the activation of caspase-11-dependent inflammasome and the consequent release of the pro-tumorigenic IL-1α. [edited by author]
Cardiac fibroblast in development and wound healing
Creators: name: Ubil, Eric
name: Deb, Arjun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Cardiac fibroblasts are the most abundant cell type in the mammalian heart and comprise approximately two-thirds of the total number of cardiac cell types. During development, epicardial cells undergo epithelial-mesenchymal-transition to generate cardiac fibroblasts that subsequently migrate into the developing myocardium to become resident cardiac fibroblasts. Fibroblasts form a structural scaffold for the attachment of cardiac cell types during development, express growth factors and cytokines and regulate proliferation of embryonic cardiomyocytes. In post natal life, cardiac fibroblasts play a critical role in orchestrating an injury response. Fibroblast activation and proliferation early after cardiac injury are critical for maintaining cardiac integrity and function, while the persistence of fibroblasts long after injury leads to chronic scarring and adverse ventricular remodeling. In this review, we discuss the physiologic function of the fibroblast during cardiac development and wound healing, molecular mediators of activation that could be possible targets for drug development for fibrosis and finally the use of reprogramming technologies for reversing scar. This article is part of a Special Issue entitled "Myocyte-Fibroblast Signalling in Myocardium."
title: The role of Magnetic Resonance Imaging and Diffusion-Weighted imaging in the detection of vascular involvement in Endometrial Stromal Sarcoma
Creators: name: Landolfi, Federica
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Multidisciplinary cancer care
subject: Imaging sequences
subject: MR
subject: Oncology
subject: Genital / Reproductive system female

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Describe the typical Magnetic Resonance Imaging (MRI) features of Endometrial Stromal Sarcoma with emphasis on the role of Diffusion- Weighted Imaging (DWI) as useful tool for the detection of vascular...
Constraining Extended Gravity Models by S2 star orbits around the Galactic Centre
Creators: name: Capozziello, S.
name: Borka, D.
name: Jovanović, P.
name: Jovanović, V. Borka
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We investigate the possibility to explain theoretically the observed deviations of S2 star orbit around the Galactic Centre using gravitational potentials derived from modified gravity models in absence of dark matter. To this aim, an analytic fourth-order theory of gravity, non-minimally coupled with a massive scalar field is considered. Specifically, the interaction term is given by analytic functions $f(R)$ and $f(R,ϕ)$ where $R$ is the Ricci scalar and $ϕ$ is a scalar field whose meaning can be related to further gravitational degrees of freedom. We simulate the orbit of S2 star around the Galactic Centre in $f(R)$ (Yukawa-like) and $f(R,ϕ)$ (Sanders-like) gravity potentials and compare it with NTT/VLT observations. Our simulations result in strong constraints on the range of gravity interaction. In the case of analytic functions $f(R)$, we are not able to obtain reliable constraints on the derivative constants $f_1$ and $f_2$, because the current observations of S2 star indicated that they may be highly mutually correlated. In the case of analytic functions $f(R,ϕ)$, we are able to obtain reliable constraints on the derivative constants $f_0$, $f_R$, $f_{RR}$, $f_ϕ$, $f_{ϕϕ}$ and $f_{ϕR}$. The approach we are proposing seems to be sufficiently reliable to constrain the modified gravity models from stellar orbits around Galactic Centre.
description: 9 pages, 6 figure to appear in Phys. Rev. D
Generation of anomalous flows near the bow shock by its interaction with interplanetary discontinuities
Creators: name: Lin, Y
Publisher: name: Auburn University
Year: 1997

description: Two-dimensional hybrid simulations using a curvilinear coordinate system are carried out to study the interaction of the Earth's bow shock (BS) with an interplanetary directional discontinuity. In particular, plasma flow patterns are examined. In the interaction of the bow shock with an interplanetary tangential discontinuity (TD), a bulge of magnetic field and plasma may be present near the intersection between the fronts of the BS and the TD. The bulge expands to the upstream and is embedded in the solar wind. High magnetic field and ion density are present in the boundary regions of the bulge, and the temperature in the bulge is significantly higher than that in the ambient solar wind. A core of low density and sometimes low field is present inside the bulge. The flow speed changes from supersonic in the solar wind to subsonic throughout the bulge. A strong sunward deflection in flow velocity is present both in the bulge and in the magnetosheath behind the bulge. The presence of such hot anomalous flows depends on the direction and symmetry condition of the upstream motional electric field. The formation of the bulge and the associated anomalous flows is found to be mainly due to (1) the reflected ions which are focused to TD under the proper electric field conditions, (2) the unbalanced pressure associated with the geometry change and reformation of the BS which causes the expansion of downstream and the sunward motion of ions, or (3) the occurrence of magnetic reconnection in the current sheet. In the interaction of the BS with an interplanetary rotational discontinuity (RD), the flow may be deflected sunward by the magnetic tension force associated with the resulting rotational discontinuities and slow shocks in the magnetosheath. It is suggested that the observed anomalous flow events upstream of the bow shock may be due to the BS/TD interaction, and both BS/RD and BS/TD interactions may generate strong sunward flow deflections in the magnetosheath.
title: Stellungnahme zur Institutionellen Akkreditierung der Fachhochschule Clara Hoffbauer Potsdam
Creators: name: German Science And Humanities Council
Publisher: name: German Science and Humanities Council
Year: 2022
Subjects: Akkreditierung
Private Hochschulen
Qualitätssicherung
interdisziplinäre Studienangebote
Hochschulförmigkeit
Fachhochschule Clara Hoffbauer Potsdam
Akkreditierungszeitraum 5 Jahre

description: Die Fachhochschule Clara Hoffbauer Potsdam wird vom Wissenschaftsrat unter Auflagen für die Dauer von fünf Jahren akkreditiert. Sie ist eine Hochschule für angewandte Wissenschaften mit dualen Bachelorstudienangeboten in den Bereichen  Soziale Arbeit und Pädagogik mit einem künstlerisch-ästhetischen Profil. Im Wintersemester 2021/2022 waren an der Hochschule  hauptberufliche Professorinnen und Professoren mit einem Stellenumfang von 8,65 Vollzeitäquivalenten (VZÄ) einschließlich Hochschulleitung beschäftigt und knapp 300 Studierende eingeschrieben.
Sequencing of 18S DNA from Xiaojiang plankton
Creators: name: Li, XueRong
name: He, Yun Rui
name: Yang, XiaoJun
name: Wang, JiShan
name: Wang, Mo
Publisher: name: figshare
Year: 2023
Subjects: Freshwater ecology

description: The total DNA of the plankton was extracted using the Water DNA Kit (Omega, USA) and following the manufacturer's the instructions. The total DNA of the plankton was extr MiSeq platform (Illumina) was used for computer sequencing after a qualified library check.
Environmental Politics in Authoritarian Regimes: Waste Management in Russian Regions – Appendix
Creators: name: Masyutina, Olga
name: Paustyan, Ekaterina
name: Yakovlev, Grigory
Publisher: name: Brill Online
Year: 2023
Subjects: classificationCode: 439999
subject: Other history, heritage and archaeology not elsewhere classified
classificationCode: 470202
subject: Asian cultural studies
classificationCode: 470206
subject: Cultural studies of nation and region
classificationCode: 440805
subject: Environmental politics
classificationCode: 440807
subject: Government and politics of Asia and the Pacific

description: Russian regions exhibit significant variation in their waste management efforts, despite the urgency of the problem and the importance of waste management for all regional governments. To examine this variation, we apply the concept of authoritarian environmentalism, which suggests that authoritarian governments have distinctive capabilities for tackling certain environmental challenges. Analysis of a regional panel data set for the period 2012-2019 shows that our measure of the degree of authoritarianism – the share of votes for the ruling party United Russia in parliamentary elections – has a strong positive effect on the share of recycled waste in the Russian regions. This result indicates that more authoritarian regions tend to recycle more household waste than less authoritarian regions. However, it could also be the case that more authoritarian governments are simply more likely to manipulate their environmental statistics to show better environmental performance.
CXCR4 blockade induces atherosclerosis by affecting neutrophil function
Creators: name: Kramp, Birgit
name: Gullestad, Lars
name: van Santbrink, Peter J.
name: Westra, Marijke M.
name: Su, Lishan
name: Koenen, Rory R.
name: Bot, Ilze
name: Halvorsen, Bente
name: Daissormont, Isabelle T.M.N.
name: Manca, Marco
name: Bot, Martine
name: Biessen, Erik A.L.
name: Zernecke, Alma
name: Weber, Christian
name: Sluimer, Judith C.
name: Kuiper, Johan
name: de Jager, Saskia C.A.
name: Aukrust, Paul
name: Hérias, Veronica
name: Skjelland, Mona
name: van Puijvelde, Gijs H.M.
name: van Berkel, Theo J.C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The SDF-1α/CXCR4 dyad was previously shown by us and others to be instrumental in intimal hyperplasia as well as early stage atherosclerosis. We here sought to investigate its impact on clinically relevant stages of atherosclerosis in mouse and man.
Lærernes Arbejdstidsanvendelse
Creators: Styrelsen for IT og Læring
Styrelsen for Undervisning og Kvalitet
Publisher: name: Rigsarkivet
Year: 2025

description: Understøttelse af behov for at kunne følge udviklingen i andelen af lærernes arbejdstid, der blev brugt på elevsamvær og med direkte læringsformål.
Global hybrid simulation of the dayside reconnection layer and associated field-aligned currents
Creators: name: Lin, Y
Publisher: name: Auburn University
Year: 2001

description: A two-dimensional global hybrid simulation is carried out to study the structure of the magnetopause boundary layer in the noon-midnight meridian plane associated with the dayside reconnection. In the simulation the bow shock, magnetosheath, and magnetopause are formed self-consistently by supersonic solar wind passing the geomagnetic field. The dayside reconnection is triggered by imposing a current-dependent resistivity at the subsolar magnetopause. A large-amplitude rotational discontinuity is formed in the quasi-steady reconnection layer in the northern and southern hemispheres. The rotational discontinuity possesses an electron sense, or right-hand polarization in the magnetic field as the discontinuity is formed from the X line, and the magnetic structures in the magnetopause northward and southward of the X line are asymmetric in the cases with a nonzero B-y component of the interplanetary magnetic field (IMF). However, later the rotational discontinuity tends to evolve to a structure with a smallest field rotational angle and thus may reverse its sense of the field rotation. The Walen relation is tested for electron and ion flows in the magnetopause rotational discontinuities with left-hand and right-hand polarizations. Field-aligned currents are generated in the magnetopause rotational discontinuity during the reconnection, and nearly 5% of the magnetopause currents propagate with Alfven waves along the field lines into the polar ionosphere. In addition, a weak secondary rotational discontinuity or Alfven wave pulse propagates from the reconnection site into the magnetosphere. The sense of the field-aligned currents is investigated for various values of the IMF B-y. The Hall effects on the structure of the magnetopause boundary layer and the field-aligned currents are discussed.
title: Radiological evaluation of spinopelvic alignment in patients suffering from hip-spine syndrome and clinical correlation
Creators: name: Drago, Angelica
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Musculoskeletal spine
subject: Digital radiography
subject: Diagnostic procedure
subject: Arthritides

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To assess the relationship between spinopelvic parameters changes and low back pain (LBP) improvement in patients with severe unilateral primary hip osteoarthritis (HOA), before and after total hip replacement...
title: Empfehlungen für eine zukunftsfähige Ausgestaltung von Studium und Lehre
Creators: name: German Science And Humanities Council
Publisher: name: German Science and Humanities Council
Year: 2022
Subjects: Bewertung und Steuerung
Governance
Qualität Studium
Hochschulbildung
Hochschulen
Wissenschaft
Gesellschaft

description: In seinen Empfehlungen für eine zukunftsfähige Ausgestaltung von Studium und Lehre entwirft der Wissenschaftsrat ein Bild des Hochschulstudiums als ganzheitlichen Bildungsprozess, in dem Studierende als gestaltende Akteure mitwirken. Denn Hochschulabsolventinnen und  -absolventen werden in den kommenden Jahrzehnten wesentlich zur Bewältigung der gesellschaftlichen und politischen, technologischen und ökologischen Umbrüche beitragen. Dafür müssen sie mit dynamischen, komplexen Problemen umgehen können, stetig dazulernen, kooperieren, vernetzt denken und auch ungewohnte Wege gehen. Aus Sicht des Wissenschaftsrats ist dazu ein grundlegendes Umdenken aller Akteure erforderlich.
Two-dimensional hybrid simulation of the dayside reconnection layer and associated ion transport
Creators: name: Xie, H
name: Lin, Y
Publisher: name: Auburn University
Year: 2000

description: The structure of the reconnection layer at the dayside magnetopause is studied by using a two-dimensional (2-D) hybrid code. The simulation domain is a rectangle in the at plane around an X line at the magnetopause. In our previous study the guide magnetic field B-y was assumed to be zero. In the present simulation the effects of a finite B-y on the reconnection layer are studied. In addition, the influence of shear flows on the magnetic reconnection is also investigated. In the cases with a shear flow speed DeltaV = 0, as near the subsolar region, a large-amplitude rotational discontinuity is present on the magnetosheath side of the reconnection layer, across which the magnetic field changes direction from the magnetosheath to the magnetosphere. A high-speed accelerated flow is present on the magnetospheric side of the rotational discontinuity. For a higher-latitude reconnection in the Northern Hemisphere, where a shear flow is present across the magnetopause, the structure of the reconnection layer northward of the X line is very different from that southward. Northward of the X line, the rotational discontinuity with a larger field rotational angle exists on the magnetospheric side if the shear flow speed DeltaV > 0.33(V-Am - V-As), where V-Am and V-As are the Alfven speeds in the magnetosphere and the magnetosheath, respectively. Below the X line, a thin, strong rotational discontinuity is always present on the magnetosheath side. By tracing the orbits of individual ion particles, we have performed a detailed analysis of ion transmission and reflection at the magnetopause. The average transmission (reflection) rate of the magnetosheath ions is found to be similar to 85% (15%). The reflection of the magnetosheath ions occurs mainly in the inner boundary layer.
Scattering of two photons on a quantum emitter in a one-dimensional waveguide: Exact dynamics and induced correlations
Creators: name: Nysteen, Anders
name: Kristensen, Philip Trøst
name: McCutcheon, Dara P. S.
name: Kaer, Per
name: Mørk, Jesper
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We develop a wavefunction approach to describe the scattering of two photons on a quantum emitter embedded in a one-dimensional waveguide. Our method allows us to calculate the exact dynamics of the complete system at all times, as well as the transmission properties of the emitter. We show that the non-linearity of the emitter with respect to incoming photons depends strongly on the emitter excitation and the spectral shape of the incoming pulses, resulting in transmission of the photons which depends crucially on their separation and width. In addition, for counter-propagating pulses, we analyze the induced level of quantum correlations in the scattered state, and we show that the emitter behaves as a non-linear beam-splitter when the spectral width of the photon pulses is similar to the emitter decay rate.
description: 15 pages, 7 figures
title: Acute gynecological pathology in the pediatric age
Creators: name: Barba Arce, Ana Belén
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Paediatric
subject: Genital / Reproductive system female
subject: Ultrasound
subject: MR
subject: Surgery
subject: Acute
subject: Cysts
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To review the most common urgent gynecological pathology that we can find in girls between 0 and 16 years old. To analyze the pathological findings on ultrasound and if it is needed to complete the study later with MR or CT. To know the differential...
Epoxyeicosatrienoic acids and cardioprotection: The road to translation
Creators: name: Seubert, John M.
name: Lee, Craig R.
name: Oni-Orisan, Akinyemi
name: Alsaleh, Nasser
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: AbstractCardiovascular disease, including acute myocardial infarction (AMI), is the leading cause of morbidity and mortality globally, despite well-established treatments. The discovery and development of novel therapeutics that prevent the progression of devastating consequences following AMI are thus important in reducing the global burden of this devastating disease. Scientific evidence for the protective effects of epoxyeicosatrienoic acids (EETs) in the cardiovascular system is rapidly emerging and suggests that promoting the effects of these cytochrome P450-derived epoxyeicosanoids is a potentially viable clinical therapeutic strategy. Through a translational lens, this review will provide insight into the potential clinical utility of this therapeutic strategy for AMI by 1) outlining the known cardioprotective effects of EETs and underlying mechanisms demonstrated in preclinical models of AMI with a particular focus on myocardial ischemia–reperfusion injury, 2) describing studies in human cohorts that demonstrate a relationship between EETs and associated pathways with coronary artery disease risk, and 3) discussing preclinical and clinical areas that require further investigation in order to increase the probability of successfully translating this rapidly emerging body of evidence into a clinically applicable therapeutic strategy for AMI.
title: Stellungnahme zur Institutionellen Reakkreditierung der BSP Business & Law School – Hochschule für Management und Recht, Berlin
Creators: name: German Science And Humanities Council
Publisher: name: German Science and Humanities Council
Year: 2022
Subjects: Akkreditierung
Hochschulen
Qualitätssicherung
Hochschulförmigkeit
private Hochschulen
Akkreditierungszeitraum 5 Jahre
Internationalität

description: Die BSP Business and Law School wird vom Wissenschaftsrat unter Auflagen für die Dauer von fünf Jahren reakkreditiert. Die BSP versteht sich als eine Hochschule für Management und Recht, für die ein wissenschaftlich fundiertes und zugleich anwendungsorientiertes Managementstudium mit hohem Praxisanteil kennzeichnend ist. Sie bietet ihren rund 1.500 Studierenden sieben Bachelor- und sechs Masterstudiengänge in den Bereichen Wirtschaftswissenschaften bzw. Management, Psychologie und Mode an.
Understanding the growth rate patterns of ion Bernstein instabilities driven by ring-like proton velocity distributions
Creators: name: Min, Kyungguk
name: Liu, Kaijun
Publisher: name: Auburn University
Year: 2016

description: Fast magnetosonic waves in Earth's inner magnetosphere, which have as their source ion Bernstein instabilities, are driven by hot proton velocity distributions (f(p)) with partial derivative f(p)(v(perpendicular to))/partial derivative v(perpendicular to) > 0. Two typical types of distributions with such features are ring and shell velocity distributions. Both have been used in studies of ion Bernstein instabilities and fast magnetosonic waves, but the differences between instabilities driven by the two types of distributions have not been thoroughly addressed. The present study uses linear kinetic theory to examine and understand these differences. It is found that the growth rate pattern is primarily determined by the cyclotron resonance condition and the structure of the velocity distribution in gyroaveraged velocity space. For ring-driven Bernstein instabilities, as the parallel wave number (k(parallel to)) increases, the discrete unstable modes approximately follow the corresponding proton cyclotron harmonic frequencies while they become broader in frequency space. At sufficiently large k(parallel to), the neighboring discrete modes merge into a continuum. In contrast, for shell-driven Bernstein instabilities, the curved geometry of the shell velocity distribution in gyroaveraged velocity space results in a complex alternating pattern of growth and damping rates in frequency and wave number space and confines the unstable Bernstein modes to relatively small k(parallel to) In addition, when k(parallel to) increases, the unstable modes are no longer limited to the proton cyclotron harmonic frequencies. The local growth rate peak near an exact harmonic at small k(parallel to) bifurcates into two local peaks on both sides of the harmonic when k(parallel to) becomes large.
Focal adhesion kinase antagonizes doxorubicin cardiotoxicity via p21Cip1
Creators: name: Cheng, Zhaokang
name: DiMichele, Laura A.
name: Taylor, Joan M.
name: Vaziri, Cyrus
name: Mack, Christopher P.
name: Rojas, Mauricio
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Clinical application of potent anthracycline anticancer drugs, especially doxorubicin (DOX), is limited by a toxic cardiac side effect that is not fully understood and preventive strategies are yet to be established. Studies in genetically modified mice have demonstrated that focal adhesion kinase (FAK) plays a key role in regulating adaptive responses of the adult myocardium to pathological stimuli through activation of intracellular signaling cascades that facilitate cardiomyocyte growth and survival. The objective of this study was to determine if targeted myocardial FAK activation could protect the heart from DOX-induced de-compensation and to characterize the underlying mechanisms. To this end, mice with myocyte-restricted FAK knock-out (MFKO) or myocyte-specific expression of an active FAK variant (termed SuperFAK) were subjected to DOX treatment. FAK depletion enhanced susceptibility to DOX-induced myocyte apoptosis and cardiac dysfunction, while elevated FAK activity provided remarkable cardioprotection. Our mechanistic studies reveal a heretofore unappreciated role for the protective cyclin-dependent kinase inhibitor p21 in the repression of the pro-apoptotic BH3-only protein Bim and the maintenance of mitochondrial integrity and myocyte survival. DOX treatment induced proteasomal degradation of p21, which exacerbated mitochondrial dysfunction and cardiomyocyte apoptosis. FAK was both necessary and sufficient for maintaining p21 levels following DOX treatment and depletion of p21 compromised FAK-dependent protection from DOX. These findings identify p21 as a key determinant of DOX resistance downstream of FAK in cardiomyocytes and indicate that cardiac-restricted enhancement of the FAK/p21 signaling axis might be an effective strategy to preserve myocardial function in patients receiving anthracycline chemotherapy.
title: Initial study of dose reduction and image quality in abdominal CT: a comparison between prospective and post adaptive statistical iterative reconstruction-V technique
Creators: name: Wei, Jin
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Radioprotection / Radiation dose
subject: Radiation physics
subject: CT
subject: Image manipulation / Reconstruction
subject: Technical aspects
subject: Technology assessment
subject: Physiological studies

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The purpose of this initial research is to evaluate the dose reduction and image quality with the application of prospective and post adaptive statistical iterative reconstruction-V (ASiR-V) in the abdominal CT scan on GE Revolution...
title: Stellungnahme zur Institutionellen Reakkreditierung der Hochschule für angewandte Pädagogik, Berlin
Creators: name: German Science And Humanities Council
Publisher: name: German Science and Humanities Council
Year: 2022
Subjects: Akkreditierung
Soziale Arbeit
Akkademisierung sozialer Berufe
Kindheitspädagogik
private Hochschulen
Fachhochschulen
Professionalisierung

description: Die Hochschule für angewandte Pädagogik (HSAP) wird vom Wissenschaftsrat unter einer Auflage für die Dauer von fünf Jahren reakkreditiert. Die Hochschule wurde für im Jahr 2013 gegründet und befristet staatlich anerkannt. Im Jahr 2019 erfolgte die Institutionelle Akkreditierung für einen Zeitraum von drei Jahren. Die HSAP bietet ihren rund 390 Studierenden vier duale bzw. berufsbegleitende Bachelorstudiengänge in den Bereichen Soziale Arbeit und Kindheitspädagogik an.
title: ТРАНСФОРМАЦИЯ БИЗНЕСА В УСЛОВИЯХ РАЗВИТИЯ ТЕХНОЛОГИЙ ИНТЕРНЕТА ВЕЩЕЙ
Creators: name: Башмаков, Данил
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: Статья посвящена актуальной проблеме современного развития интернета вещей (Internet of Things, IoT) и его последствиям для бизнес-организаций. Как сквозная технология IoT оказывает пронизывающее влияние на всю цепочку создания потребительской ценности, преобразуя взаимодействия всех ее участников. Изменения в структуре рыночных отношений требуют трансформации используемых бизнес-моделей и бизнес-систем. Выявление новых рыночных условий, вызванных доступностью и популярностью технологии IoT, а также соответствующих им направлений трансформации бизнеса является целью данной работы. В статье дано определение интернета вещей, показано разнообразие его использования, выделены необходимые для функционирования технологии подсистемы, а также описан процесс ее внедрения в бизнес-систему организации.
Dissipative quantum dynamics of fermions in optical lattices: a slave-spin approach
Creators: name: Bernier, Jean-Sebastien
name: Poletti, Dario
name: Kollath, Corinna
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We investigate the influence of a Markovian environment on the dynamics of interacting spinful fermionic atoms in a lattice. In order to explore the physical phenomena occurring at short times, we develop a method based on a slave-spin representation of fermions which is amenable to the investigation of the dynamics of dissipative systems. We apply this approach to two different dissipative couplings which can occur in current experiments: a coupling via the local density and a coupling via the local double occupancy. We complement our study based on this novel method with results obtained using the adiabatic elimination technique and with an exact study of a two-site model. We uncover that the decoherence is slowed down by increasing either the interaction strength or the dissipative coupling (the Zeno effect). We also find, for the coupling to the local double occupancy, that the final steady state can sustain single-particle coherence.
description: 16 pages, 10 figures
MMI-0100 inhibits cardiac fibrosis in myocardial infarction by direct actions on cardiomyocytes and fibroblasts via MK2 inhibition
Creators: name: Willis, Monte
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The cell-permeant peptide inhibitor of MAPKAP kinase 2 (MK2), MMI-0100, inhibits MK2 and downstream fibrosis and inflammation. Recent studies have demonstrated that MMI-0100 reduces intimal hyperplasia in a mouse vein graft model, pulmonary fibrosis in a murine bleomycin-induced model and development of adhesions in conjunction with abdominal surgery. MK2 is critical to the pathogenesis of ischemic heart injury as MK2 −/− mice are resistant to ischemic remodeling. Therefore, we tested the hypothesis that inhibiting MK2 with MMI-0100 would protect the heart after acute myocardial infarction (AMI) in vivo. AMI was induced by placing a permanent LAD coronary ligation. When MMI-0100 peptide was given 30 minutes after permanent LAD coronary artery ligation, the resulting fibrosis was reduced/prevented ~50% at a 2 week time point, with a corresponding improvement in cardiac function and decrease in left ventricular dilation. In cultured cardiomyocytes and fibroblasts, MMI-0100 inhibited MK2 to reduce cardiomyocyte caspase 3/7 activity, while enhancing primary cardiac fibroblast caspase 3/7 activity, which may explain MMI-0100’s salvage of cardiac function and anti-fibrotic effects in vivo. These findings suggest that therapeutic inhibition of MK2 after acute MI, using rationally-designed cell-permeant peptides, inhibits cardiac fibrosis and maintains cardiac function by mechanisms that involve inhibiting cardiomyocyte apoptosis, while enhancing primary cardiac fibroblast cell death.
title: Chest CT Findings on Pleural Tuberculosis
Creators: name: Cruz, João
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Infection
subject: Diagnostic procedure
subject: CT
subject: Thorax

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Pleural tuberculosis (TB) is the second most common presentation of extrapulmonary tuberculosis (after lymph node tuberculosis), accounting for 20% of the extrapulmonarycases and is the most common cause of pleural effusion worldwide.[1] This form...
title: Stellungnahme zur Institutionellen Reakkreditierung der Brand University of Applied Sciences, Hamburg
Creators: name: German Science And Humanities Council
Publisher: name: German Science and Humanities Council
Year: 2022
Subjects: Akkreditierung
Akkreditierungszeitraum 5 Jahre
Qualitätssicherung
Hochschulförmigkeit
private Hochschulen
Hochschulen
Internationalität

description: Die Brand University wird vom Wissenschaftsrat unter vier Auflagen für die Dauer von fünf Jahren reakkreditiert. Die Brand University of Applied Sciences (kurz Brand University) wurde im Jahr 2010 gegründet und befristet staatlich anerkannt. Die Institutionelle Erstakkreditierung erfolgte im Jahr 2017 für die Dauer von drei Jahren bzw. fünf Jahren nach Erfüllung von Auflagen. Die Hochschule bietet ihren derzeit rund 350 Studierenden zwei Bachelorstudiengänge und einen Masterstudiengang in den Bereichen Führung, Management, Gestaltung und Kommunikation von Marken an.
Børnepasningsstatistik
Creators: Danmarks Statistik
Publisher: name: Rigsarkivet
Year: 2025

description: Formålet med statistikken Børnepasning før skolestart i de kommunale og selvejende institutioner samt institutionslignende puljeordninger er at belyse omfanget af og ressourceforbruget til børnepasning i dagtilbud for børn under skolealderen til brug for sammenligning mellem kommunerne.
Global-scale hybrid simulation of dayside magnetic reconnection under southward IMF: Structure and evolution of reconnection
Creators: name: Tan, B
name: Lin, Y
name: Perez, J
name: Wang, X
Publisher: name: Auburn University
Year: 2011

description: Magnetopause reconnection is investigated with our 3-D self-consistent global hybrid simulation model. The magnetic configuration and evolution of Flux Transfer Events (FTEs) and the associated ion density and ion velocity distribution at various locations on the magnetopause are investigated. The results reveal the following. (1) Multiple X lines are formed during the magnetopause reconnection, which lead to both FTEs and quasi-steady-type reconnection under a steady solar wind condition. The resulting bipolar signature of local normal magnetic field of FTEs is consistent with satellite observations. (2) A greater-than-20% plasma temperature rise is seen at the center of a FTE, compared to that of the upstream plasma in the magnetosheath. The temperature enhancement is mainly in the direction parallel to the magnetic field because of the mixing of ion beams. (3) Flux ropes that lead to FTEs form between X lines of finite lengths and evolve relatively independently. The ion density is enhanced within FTE flux ropes because of the trapped particles, leading to a filamentary global density. (4) Different from the previous understanding based on the asymmetric density across the magnetopause, a quadrupole magnetic field signature associated with the Hall effects is found to be present around FTEs. (5) A combination of patchy reconnection and multiple X line reconnection leads to the formation of reconnected field lines from the magnetosphere to IMF, as well as the closed field lines from the magnetosphere to the magnetosphere in the magnetopause boundary layer.
Organisk støv i væksthusgartnerier
Creators: Det Nationale Forskningscenter for Arbejdsmiljø
Anne Mette Madsen
Publisher: name: Rigsarkivet
Year: 2025

description: At kvantificere eksponeringen for organisk støv og udvalgte komponenter i støvet under veldefinerede arbejdsprocesser i agurke-, tomat- og blomstergartnerier.
At identificere de arbejdsprocesser og aktiviteter i arbejdsprocesserne, der fører til høj eksponering.
title: MR-characteristics of the neurovascular relationship as a probable predictor of trigeminal neuralgia
Creators: name: Mershina, Elena
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Seizure disorders
subject: Image verification
subject: Statistics
subject: FOS: Mathematics
subject: Normal variants
subject: Diagnostic procedure
subject: MR-Angiography
subject: MR
subject: Neuroradiology peripheral nerve
subject: CNS
subject: Anatomy

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To validate MR-criteria used for diagnosis of trigeminal neuralgia...
The role of ubiquitin ligases in cardiac disease
Creators: name: Patterson, Cam
name: Willis, Monte S.
name: Tannu, Manasi
name: Pulinilkunnil, Thomas
name: Kienesberger, Petra
name: Bevilacqua, Ariana
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Rigorous surveillance of protein quality control is essential for the maintenance of normal cardiac function, while the dysregulation of protein turnover is present in a diverse array of common cardiac diseases. Central to the protein quality control found in all cells is the ubiquitin proteasome system (UPS). The UPS plays a critical role in protein trafficking, cellular signaling, and most prominently, protein degradation. As ubiquitin ligases (E3s) control the specificity of the UPS, their description in the cardiomyocyte has highlighted how ubiquitin ligases are critical to the turnover and function of the sarcomere complex, responsible for the heart’s required continuous contraction. In this review, we provide an overview of the UPS, highlighting a comprehensive overview of the cardiac ubiquitin ligases identified to date. We then focus on recent studies of new cardiac ubiquitin ligases outlining their novel roles in protein turnover, cellular signaling, and the regulation of mitochondrial dynamics and receptor turnover in the pathophysiology of cardiac hypertrophy, cardiac atrophy, myocardial infarction, and heart failure.
Anomalous scaling of passive scalar fields advected by the Navier-Stokes velocity ensemble: Effects of strong compressibility and large-scale anisotropy
Creators: name: Antonov, N. V.
name: Kostenko, M. M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences
subject: 76F30

description: The field theoretic renormalization group and the operator product expansion are applied to two models of passive scalar quantities (the density and the tracer fields) advected by a random turbulent velocity field. The latter is governed by the Navier--Stokes equation for compressible fluid, subject to external random force with the covariance $\propto δ(t-t') k^{4-d-y}$, where $d$ is the dimension of space and $y$ is an arbitrary exponent. The original stochastic problems are reformulated as multiplicatively renormalizable field theoretic models; the corresponding renormalization group equations possess infrared attractive fixed points. It is shown that various correlation functions of the scalar field, its powers and gradients, demonstrate anomalous scaling behavior in the inertial-convective range already for small values of $y$. The corresponding anomalous exponents, identified with scaling (critical) dimensions of certain composite fields ("operators" in the quantum-field terminology), can be systematically calculated as series in $y$. The practical calculation is performed in the leading one-loop approximation, including exponents in anisotropic contributions. It should be emphasized that, in contrast to Gaussian ensembles with finite correlation time, the model and the perturbation theory presented here are manifestly Galilean covariant. The validity of the one-loop approximation and comparison with Gaussian models are briefly discussed.
description: 25 pages, LaTeX source with two PDF figures
Amphibian Speciation Rates Support a General Role of Mountains as Biodiversity Pumps
Creators: name: García-Rodríguez, Adrián
name: Martínez, Pablo
name: Oliveira, Brunno
name: Velasco, Julián
name: Pyron, Alexander
name: Costa, Gabriel
Publisher: name: University of Chicago Press
Year: 2021
Subjects: amphibians
macroecology
macroevolution
FiSSE
HiSSE
topographic complexity

description: Continental mountain areas cover <15% of global land surface, yet these regions concentrate >80% of global terrestrial diversity. One prominent hypothesis to explain this pattern proposes that high mountain diversities could be explained by higher diversification rates in regions of high topographic complexity (HTC). While high speciation in mountains has been detected for particular clades and regions, the global extent to which lineages experience faster speciation in mountains remains unknown. Here we addressed this issue using amphibians as a model system (>7,000 species), and we found that families showing high speciation rates contain a high proportion of species distributed in mountains. Moreover, we found that lineages inhabiting areas of HTC speciate faster than lineages occupying areas that are topographically less complex. When comparing across regions, we identified the same pattern in five biogeographical realms where higher speciation rates are associated with higher levels of complex topography. Low-magnitude differences in speciation rates between some low and high complex topographies suggest that high mountain diversity is also affected by low extinction and/or high colonization rates. Nevertheless, our results bolster the importance of mountains as engines of speciation at different geographical scales and highlight their importance for the conservation of global biodiversity.
title: Leitfaden der Institutionellen Akkreditierung nichtstaatlicher Hochschulen
Creators: name: German Science And Humanities Council
Publisher: name: German Science and Humanities Council
Year: 2022
Subjects: institutionelle Akkreditierung
private Hochschulen
Qualitätssicherung nichtstaatlicher Hochschulen
Leitfaden Hochschulförmigkeit
Hochschulen
Konzeptprüfung
staatliche Anerkennung

description: Konzeptprüfung und Institutionelle Akkreditierung dienen den Ländern als Gutachten zur Erweiterung ihrer Entscheidungsgrundlage für die staatliche Anerkennungspraxis. In grundlegend überarbeiteter Fassung wurden auf den Sommersitzungen des Wissenschaftsrats in Magdeburg der „Leitfaden der Institutionellen Akkreditierung nichtstaatlicher Hochschulen“ sowie der „Leitfaden der Konzeptprüfung nichtstaatlicher Hochschulen in Gründung“ verabschiedet. Die Revision beider Leitfäden berücksichtigt insbesondere neue gesetzliche Regelungen der staatlichen Anerkennung nichtstaatlicher Hochschulen sowie der Institutionellen Akkreditierung. Anträge nach den bisherigen Leitfäden sind letztmalig zum 1. Dezember 2022 (Institutionelle Akkreditierung) bzw. dem 15. Januar 2023 (Konzeptprüfung) möglich.