Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk
Creators: name: Liu, Jingjing
name: Prager - Van Der Smissen, Wendy J. C.
name: Collée, J. Margriet
name: Bolla, Manjeet K.
name: Wang, Qin
name: Michailidou, Kyriaki
name: Dennis, Joe
name: Ahearn, Thomas U.
name: Aittomäki, Kristiina
name: Ambrosone, Christine B.
name: Andrulis, Irene L.
name: Anton-Culver, Hoda
name: Antonenkova, Natalia N.
name: Arndt, Volker
name: Arnold, Norbert
name: Aronson, Kristan J.
name: Augustinsson, Annelie
name: Auvinen, Päivi
name: Becher, Heiko
name: Beckmann, Matthias W.
name: Behrens, Sabine
name: Bermisheva, Marina
name: Bernstein, Leslie
name: Bogdanova, Natalia V.
name: Bogdanova-Markov, Nadja
name: Bojesen, Stig E.
name: Brauch, Hiltrud
name: Brenner, Hermann
name: Briceno, Ignacio
name: Brucker, Sara Y.
name: Brüning, Thomas
name: Burwinkel, Barbara
name: Cai, Qiuyin
name: Cai, Hui
name: Campa, Daniele
name: Canzian, Federico
name: Castelao, Jose E.
name: Chang-Claude, Jenny
name: Chanock, Stephen J.
name: Choi, Ji-Yeob
name: Christiaens, Melissa
name: Clarke, Christine L.
name: Couch, Fergus J.
name: Czene, Kamila
name: Daly, Mary B.
name: Devilee, Peter
name: Dos-Santos-Silva, Isabel
name: Dwek, Miriam
name: Eccles, Diana M.
name: Eliassen, A. Heather
name: Fasching, Peter A.
name: Figueroa, Jonine
name: Flyger, Henrik
name: Fritschi, Lin
name: Gago-Dominguez, Manuela
name: Gapstur, Susan M.
name: García-Closas, Montserrat
name: García-Sáenz, José A.
name: Gaudet, Mia M.
name: Giles, Graham G.
name: Goldberg, Mark S.
name: Goldgar, David E.
name: Guénel, Pascal
name: Haiman, Christopher A.
name: Håkansson, Niclas
name: Hall, Per
name: Harrington, Patricia A.
name: Hart, Steven N.
name: Hartman, Mikael
name: Hillemanns, Peter
name: Hopper, John L.
name: Hou, Ming-Feng
name: Hunter, David J.
name: Huo, Dezheng
name: Ito, Hidemi
name: Iwasaki, Motoki
name: Jakimovska, Milena
name: Jakubowska, Anna
name: John, Esther M.
name: Kaaks, Rudolf
name: Kang, Daehee
name: Keeman, Renske
name: Khusnutdinova, Elza
name: Kim, Sung-Won
name: Kraft, Peter
name: Kristensen, Vessela N.
name: Kurian, Allison W.
name: Le Marchand, Loic
name: Li, Jingmei
name: Lindblom, Annika
name: Lophatananon, Artitaya
name: Luben, Robert N.
name: Lubiński, Jan
name: Mannermaa, Arto
name: Manoochehri, Mehdi
name: Manoukian, Siranoush
name: Margolin, Sara
name: Mariapun, Shivaani
name: Matsuo, Keitaro
name: Maurer, Tabea
name: Mavroudis, Dimitrios
name: Meindl, Alfons
name: Menon, Usha
name: Milne, Roger L.
name: Muir, Kenneth
name: Mulligan, Anna Marie
name: Neuhausen, Susan L.
name: Nevanlinna, Heli
name: Offit, Kenneth
name: Olopade, Olufunmilayo I.
name: Olson, Janet E.
name: Olsson, Håkan
name: Orr, Nick
name: Park, Sue K.
name: Peterlongo, Paolo
name: Peto, Julian
name: Plaseska-Karanfilska, Dijana
name: Presneau, Nadege
name: Rack, Brigitte
name: Rau-Murthy, Rohini
name: Rennert, Gad
name: Rennert, Hedy S.
name: Rhenius, Valerie
name: Romero, Atocha
name: Ruebner, Matthias
name: Saloustros, Emmanouil
name: Schmutzler, Rita K.
name: Schneeweiss, Andreas
name: Scott, Christopher
name: Shah, Mitul
name: Shen, Chen-Yang
name: Shu, Xiao-Ou
name: Simard, Jacques
name: Sohn, Christof
name: Southey, Melissa C.
name: Spinelli, John J.
name: Tamimi, Rulla M.
name: Tapper, William J.
name: Teo, Soo H.
name: Terry, Mary Beth
name: Torres, Diana
name: Truong, Thérèse
name: Untch, Michael
name: Vachon, Celine M.
name: Van Asperen, Christi J.
name: Wolk, Alicja
name: Yamaji, Taiki
name: Zheng, Wei
name: Ziogas, Argyrios
name: Ziv, Elad
name: Torres-Mejía, Gabriela
name: Dörk, Thilo
name: Swerdlow, Anthony J.
name: Hamann, Ute
name: Schmidt, Marjanka K.
name: Dunning, Alison M.
name: Pharoah, Paul D. P.
name: Easton, Douglas F.
name: Hooning, Maartje J.
name: Martens, John W. M.
name: Hollestelle, Antoinette
name: Sahlberg, Kristine K.
name: Børresen-Dale, Anne-Lise
name: Ottestad, Lars
name: Kåresen, Rolf
name: Schlichting, Ellen
name: Holmen, Marit Muri
name: Sauer, Toril
name: Haakensen, Vilde
name: Engebråten, Olav
name: Naume, Bjørn
name: Fosså, Alexander
name: Kiserud, Cecile E.
name: Reinertsen, Kristin V.
name: Helland, Åslaug
name: Riis, Margit
name: Geisler, Jürgen
name: Alnæs, Grethe I. Grenaker
name: Bathen, Tone F.
name: Borgen, Elin
name: Fritzman, Britt
name: Garred, Øystein
name: Geitvik, Gry Aarum
name: Hofvind, Solveig
name: Langerød, Anita
name: Lingjærde, Ole Christian
name: Mælandsmo, Gunhild Mari
name: Russnes, Hege G
name: Skjerven, Helle Kristine
name: Sørlie, Therese
name: Clarke, Christine
name: Marsh, Deborah
name: Scott, Rodney
name: Baxter, Robert
name: Yip, Desmond
name: Carpenter, Jane
name: Davis, Alison
name: Pathmanathan, Nirmala
name: Simpson, Peter
name: Graham, Dinny
name: Sachchithananthan, Mythily
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Article
/631/67
/631/208
/692/4028
/692/499
article

description: Abstract: In breast cancer, high levels of homeobox protein Hox-B13 (HOXB13) have been associated with disease progression of ER-positive breast cancer patients and resistance to tamoxifen treatment. Since HOXB13 p.G84E is a prostate cancer risk allele, we evaluated the association between HOXB13 germline mutations and breast cancer risk in a previous study consisting of 3,270 familial non-BRCA1/2 breast cancer cases and 2,327 controls from the Netherlands. Although both recurrent HOXB13 mutations p.G84E and p.R217C were not associated with breast cancer risk, the risk estimation for p.R217C was not very precise. To provide more conclusive evidence regarding the role of HOXB13 in breast cancer susceptibility, we here evaluated the association between HOXB13 mutations and increased breast cancer risk within 81 studies of the international Breast Cancer Association Consortium containing 68,521 invasive breast cancer patients and 54,865 controls. Both HOXB13 p.G84E and p.R217C did not associate with the development of breast cancer in European women, neither in the overall analysis (OR = 1.035, 95% CI = 0.859–1.246, P = 0.718 and OR = 0.798, 95% CI = 0.482–1.322, P = 0.381 respectively), nor in specific high-risk subgroups or breast cancer subtypes. Thus, although involved in breast cancer progression, HOXB13 is not a material breast cancer susceptibility gene.