cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Evaluating Versal AI Engines for option price discovery in market risk analysis
Creators: name: Klaisoongnoen, Mark
name: Brown, Nick
name: Dykes, Tim
name: Jones, Jessica R.
name: Haus, Utz-Uwe
Publisher: name: arXiv
Year: 2024
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Computer and information sciences

description: Whilst Field-Programmable Gate Arrays (FPGAs) have been popular in accelerating high-frequency financial workload for many years, their application in quantitative finance, the utilisation of mathematical models to analyse financial markets and securities, is less mature. Nevertheless, recent work has demonstrated the benefits that FPGAs can deliver to quantitative workloads, and in this paper, we study whether the Versal ACAP and its AI Engines (AIEs) can also deliver improved performance. We focus specifically on the industry standard Strategic Technology Analysis Center's (STAC) derivatives risk analysis benchmark STAC-A2. Porting a purely FPGA-based accelerator STAC-A2 inspired market risk (SIMR) benchmark to the Versal ACAP device by combining Programmable Logic (PL) and AIEs, we explore the development approach and techniques, before comparing performance across PL and AIEs. Ultimately, we found that our AIE approach is slower than a highly optimised existing PL-only version due to limits on both the AIE and PL that we explore and describe.
description: Author accepted version of paper accepted to the 32nd ACM/SIGDA International Symposium on Field-Programmable Gate Arrays
Sturnus luteolus Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Passeriformes
Sturnidae
Sturnus
Sturnus luteolus

description: Sturnus luteolus [spec. nov.]
S. luteus, capite fusco, pectore maculato, alis fuscoluteis.
Sturnus luteus benghalensis. Edw. av. 186. t. 186.
Pica maderaspatana sturni ad instar maculata. Raj. av. 195. n. 7. t. 1. f. 7.
Habitat in India.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 167, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
title: ADCO, Cartulaire de Cîteaux pour la grange et seigneurie d'Ouges (XVe siècle), Cart. 173 (11 H 939), 226 folios, f. 0429
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2015
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire de Cîteaux pour la grange et seigneurie d'Ouges (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 173 (11 H 939), 226 folios, f. 0429, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour la grange et seigneurie d'Ouges (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 173 (11 H 939), 226 folios, f. 0429, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
This most uncertain of all sciences.odt
Creators: name: Wilkin, Stanley
Publisher: name: figshare
Year: 2018
Subjects: subject: 111502 Clinical Pharmacology and Therapeutics
subject: FOS: Clinical medicine
subject: 111710 Health Counselling
subject: FOS: Health sciences
subject: Health Care
subject: 111712 Health Promotion
subject: 111708 Health and Community Services
subject: 111602 Human Biophysics
subject: FOS: Basic medicine
subject: 111005 Mental Health Nursing

description: This paper explores the veracity of psychiatric ideas and practices through consideration of psychiatric ideas and thinking as expressed through three psychiatric papers addressed principally to the monoamine hypothesis. It will consider the validity of extrapolating ideas on human mental functions from research on animals, and the dangers involved. The methods used are an examination of the scientific propositions of the three papers, chosen at random but reflecting different time periods and psychiatric thinking, an examination of alternative perspectives and textual examination of language used. Opposing views and in-depth examination of attitudes and ideas will be highlighted. The observed effects of psychotropic drugs on clients will complete this examination.
Does a distinct quasi many-body localized phase exist? A numerical study of a translationally invariant system in the thermodynamic limit
Creators: name: Sirker, J.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We consider a quench in an infinite spin ladder describing a system with two species of bosons in the limit of strong interactions. If the heavy bosonic species has infinite mass the model becomes a spin chain with quenched binary disorder which shows true Anderson localization (AL) or many-body localization (MBL). For finite hopping amplitude $J'$ of the heavy particles, on the other hand, we find an exponential polarization decay with a relaxation rate which depends monotonically on $J'$. Furthermore, the entanglement entropy changes from a constant (AL) or logarithmic (MBL) scaling in time $t$ for $J'=0$ to a sub-ballistic power-law, $S_{\textrm{ent}}\sim t^α$ with $α< 1$, for finite $J'$. We do not find a distinct regime in time where the dynamics for $J'\neq 0$ shows the characteristics of an MBL phase. Instead, we discover a time regime with distinct dephasing and entanglement times, different both from a localized and a fully ergodic phase.
description: Extensive exact diagonalization data added showing that for $1/J'> vt is essential
Nucleate boiling: Microlayer formation, depletion, and contribution to bubble growth
Creators: name: Hänsch, Susann
Publisher: name: Imperial College London
Year: 2018

description: The growth of a vapour bubble at a heated surface involves various fluid mechanics, heat transfer and phase change phenomena. An understanding of the fundamentals of these phenomena on the scale of single bubbles is interesting in its own right from a scientific point of view, and is helpful for the further improvement of macroscopic boiling models. Vapour generation during nucleate boiling at atmospheric pressure conditions is known to occur not only from the curved surface of the bubble, but also from a very thin film of liquid forming between the heated wall and the underside of the bubble, the so-called ‘microlayer’. Microlayers are widely observed in experiments, but theoretical understanding of their formation, behaviour and significance to bubble growth is limited. This thesis presents various studies of the formation, depletion, and contribution to bubble growth of these microlayers. Mechanistic hydrodynamic-only CFD simulations of the formation of such microlayers during the early bubble growth stages, tracking the vapour-liquid interface, are performed. These computational models demonstrate that the balance between inertial and surface tension forces, and the resulting bubble shape, determine the presence and overall extent of microlayers underneath steam bubbles. Their thickness is strongly influenced by viscous effects in the near-wall region. Having identified the underlying physical mechanism behind the formation of microlayers, the thesis then presents CFD simulations of their formation and simultaneous, physically self- consistent evaporative extinction, including the conjugate heat transfer into the solid substrate. Identification of the classes of conditions under which microlayers are likely to be formed is presented, along with an assessment of their relative contribution of vapour to the overall bubble growth.
Natural convection and pool boiling studies of nanofluids
Creators: name: Kouloulias, Konstantinos
Publisher: name: Imperial College London
Year: 2017

description: The present PhD thesis sheds light on the physical mechanisms behind nanofluids, by investigating experimentally the heat and mass transfer behaviour of nanofluids under natural convection and pool boiling heat transfer. Nanofluids represent a new class of heat transfer fluids, engineered by dispersing and stably suspending nanoparticles in traditional heat transfer fluids. Nanoparticles have the potential to considerably enhance the heat transfer performance of the base fluids, in concentrations starting from as low as 0.0001 vol.%, with theoretically limited drawbacks compared to milli- or micron-sized particles. Despite the reported promising characteristics of nanofluids, the physics of the underlying processes have not yet thoroughly been established and a controversy exists concerning their capability and applicability in engineering applications. With respect to natural convection heat transfer in a Rayleigh-Bénard cell, it was found that the presence of Al2O3 nanoparticles in deionised water, decreases the heat transfer coefficient of the base fluid, due to the sedimentation of nanoparticles, as a consequence of poor nanofluid stability. Meanwhile, it was shown that when nanofluids that exhibit acidic behaviour are used, the attained stability is superior, and the heat transfer deterioration is minimal. By using a laser-based velocimetry technique, it was found that the presence of a minute amount of Al2O3 nanoparticles in deionised water significantly alters its mass transfer behaviour in the bulk region of turbulent Rayleigh-Bénard convection. The spatially and temporally averaged absolute velocity of nanofluids was higher than that of water alone, while the spatially and temporally averaged turbulent intensity was lower, as measured in the field of view. Regarding subcooled pool boiling heat transfer, it was observed that the suspended Al2O3 nanoparticles in deionised water notably modify the bubble dynamics and nucleation site activity at the heating surface, due to nanoparticle deposition. The combination of traditional heat transfer experiments, novel laser-based velocimetry measurements and a visualisation study revealed the contribution of nanoparticles on the heat and mass transport mechanisms of conventional heat transfer fluids, in a comprehensive manner. The outcome of this thesis is a step towards the evaluation of the applicability of nanofluids in demanding cooling applications, where mixed heat transfer modes are involved, such as those employed in the current generation of experimental fusion reactors and future fusion power plants.
Brownian oscillator with time-dependent strength: a delta function protocol
Creators: name: Plyukhin, Alex V.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We consider a classical Brownian oscillator of mass $m$ driven from an arbitrary initial state by varying the stiffness $k(t)$ of the harmonic potential according to the protocol $k(t)=k_0+a\,δ(t)$, involving the Dirac delta function. The microscopic work performed on the oscillator is shown to be $W=(a^2/2m)\,q^2-a q v$, where $q$ and $v$ are the coordinate and velocity in the initial state. If the initial distribution of $q$ and $v$ is the equilibrium one with temperature $T$, the average work is $\langle W \rangle=a^2T/(2m\,k_0)$ and the distribution $f(W)$ has the form of the product of exponential and modified Bessel functions. The distribution is asymmetric and diverges as $W\to 0$. The system's response for $t>0$ is evaluated for specific models.
description: 14 pages, 4 figures
Sturnus contra Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Passeriformes
Sturnidae
Sturnus
Sturnus contra

description: Sturnus contra [spec. nov.]
S. fuscus, macula oculari fascia alari abdomineque albis.
Sturnus ex albo & fusco varius benghalensis. Edw. av. 187. Alb. av. 3. p, 20. t. 21.
Habitat in India.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 167, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Kinematics of nearby subdwarfs
Creators: name: Fuchs, B.
name: Jahreiss, H.
name: Wielen, R.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: A sample of subdwarfs with accurate space velocities and standarized metallicities is presented. This was constructed by combining Hipparcos parallaxes ond proper motions with radial velocities and metallicities from Carney et al. (1994; CLLA). The accurate Hipparcos parallaxes lead to an - upward - correction factor of 11% of the photometric distance scale of CLLA. The kinematical behaviour of the subdwarfs is discussed in particular in relation to their metallicities. Most of the stars turn out to be thick disk stars, but the sample contains also many genuine halo stars. While the extreme metal poor halo does not rotate, a population of subdwarfs with metallicities in the range -1.6 < [Fe/H] < -1.0 dex appears to rotate around the galactic center with a mean rotation speed of about 100 km/s.
description: Latex, 4 pages, 6 figures. To appear in the proceedings of the `Galaxy Evolution' conference held in Meudon, September, 21 - 25, 1998
Discovery of novel inhibitors for Pseudomonas aeruginosa lipase enzyme from in silico and in vitro studies
Creators: name: Gholami, Asma
name: Minai-Tehrani, Dariush
name: Farewell, Anne
name: Eriksson, Leif A.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Pseudomonas aeruginosa is an opportunistic pathogen prone to developing drug-resistance and is a major cause of infection for burn patients and patients suffering from cystic fibrosis or are hospitalized in intensive care units. One of the virulence factors of this bacterium is the lipase enzyme that degrades the extracellular matrix of the host tissue and promotes invasion. Bromhexine is a mucolytic drug and has recently been reported to function as a competitive inhibitor of lipase with an IC50 value of 49 µM. In the present study, an attempt was made to identify stronger inhibitors from the ChEMBL database of bioactive compounds, as compared to the reference compound Bromhexine. Following docking and MD simulations, four hit compounds (N1-N4) were selected that showed promising binding modes and low RMSD values indicative of stable protein-ligand complexes. From subsequent binding pose metadynamics (BPMD) simulations, two of these (N2 and N4) stood out as more potent than Bromhexine, displaying stable interactions with residues in the catalytic site of the enzyme. Biological investigations were performed for all four compounds. Among them, the same two hit compounds were found to be the most effective binders with IC50 values of 22.1 and 27.5 µM, respectively; i.e. roughly twice as efficient as the reference Bromhexine. Taken together, our results show that these hits can be promising new candidates to use as leads for the development of drugs targeting the P. aeruginosa lipase enzyme. Communicated by Ramaswamy H. Sarma
Synthetic turbulent inflow generator using machine learning
Creators: name: Fukami, Kai
name: Nabae, Yusuke
name: Kawai, Ken
name: Fukagata, Koji
Publisher: name: arXiv
Year: 2018
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We propose a methodology for generating time-dependent turbulent inflow data with the aid of machine learning (ML), which has a possibility to replace conventional driver simulations or synthetic turbulent inflow generators. As for the ML model, we use an auto-encoder type convolutional neural network (CNN) with a multi-layer perceptron (MLP). For the test case, we study a fully-developed turbulent channel flow at the friction Reynolds number of ${\rm Re}_τ = 180$ for easiness of assessment. The ML models are trained using a time series of instantaneous velocity fields in a single cross-section obtained by direct numerical simulation (DNS) so as to output the cross-sectional velocity field at a specified future time instant. From the a priori test in which the output from the trained ML model are recycled to the input, the spatio-temporal evolution of cross-sectional structure is found to be reasonably well reproduced by the proposed method. The turbulence statistics obtained in the a priori test are also, in general, in reasonable agreement with the DNS data, although some deviation in the flow rate was found. It is also found that the present machine-learned inflow generator is free from the spurious periodicity, unlike the conventional driver DNS in a periodic domain. As an a posteriori test, we perform DNS of inflow-outflow turbulent channel flow with the trained ML model used as a machine-learned turbulent inflow generator (MLTG) at the inlet. It is shown that the present MLTG can maintain the turbulent channel flow for a long time period sufficient to accumulate turbulent statistics, with much lower computational cost than the corresponding driver simulation. It is also demonstrated that we can obtain accurate turbulent statistics by properly correcting the deviation in the flow rate.
description: 26 pages, 11 figures
Herodotus, the Old Sappho and the Newest Sappho
Creators: name: Donelli, Giulia
Publisher: name: Fondazione Università Ca’ Foscari Venezia, Italia
Year: 2021

description:

This paper focuses on Herodotus’ mention of Sappho in the Histories (2.134-5). Through the analysis of some of the extant sources on the involvement of her brother Charaxus with the hetaira Doricha/Rhodopis, it advances an interpretation of Sappho’s fr. 55 V as relevant to the affair. It then draws attention to Herodotus’ description of courtesans, in the same context, with the poetic term ἀοίδιμος. The adjective occurs only once in Homer, in the self-deprecating words that Helen speaks to Hector (Il. 6.354-8). Such Homeric echo might be understood as triggering an allusion to Sappho’s own treatment of Helen in fr. 16 V: Helen’s behaviour in that poem in fact closely matches no one other’s than Charaxus’ own. The possibility that Herodotus might be engaging with more than one Sapphic poem in this context finds a parallel in his engagement with Pindar’s poetry in 3.38, where, it has been argued, he ‘contaminates’ two distinct Pindaric intertexts (frr. 169a and 215 S.-M.). The contamination of thematically linked poems might in turn suggest, in both cases, sympotic reperformances as possible contexts for Herodotus’ reception of Greek lyric poetry.

description: Lexis
The Silent Prophet of the Muses: Text and Scene in Aesch. fr. 60 R.
Creators: name: Berardi, Pietro
Publisher: name: Fondazione Università Ca’ Foscari Venezia, Italia
Year: 2021

description:

Among the fragmentary plays of Aeschylus, the Lycurgeia has received particular attention from scholars in all periods, since it has been unanimously recognized as the literary archetype of the Dionysian tetralogy that inspired Euripides’ Bacchae. Handling the extant fragments nonetheless requires considerable effort, due to problems related to the citation technique employed by the testimonia as well as corruptions in the manuscript tradition over the course of the centuries. In this respect, one fragment (Aesch. fr. 60 R., test. schol. vet. Tr. Aristoph. Av. 276 a-b, II 3, 49 Holwerda + Suda μ1301 Adler) of Edonians, the first play of the tetralogy, is particularly difficult as a result of the apparently incurable corruption that afflicts it. Beginning from the textual assessment of Radt (TrGF III 181), the main purpose of this paper will be to shed new light on the editorial issues affecting this fragment, by offering both a fresh collation of the variant readings in the manuscripts of Aristophanes and a meticulous examination of the most significant conjectures by editors of Aeschylus. I offer a fresh critical text of the fragment, in an attempt to demonstrate how a more accurate evaluation of the manuscript tradition might help restore part of the (allegedly) genuine Aeschylean text. In addition, I undertake a broad examination of the most salient exegetical issues, along with a hypothetical reconstruction of the performance context of the fragment.

description: Lexis
Turdus Linnaeus, 1758, gen. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Passeriformes
Turdidae
Turdus

description: Turdus [gen. nov.]
Rostrum tereti-cultratum, maxilla superiore apice deflexo.
Nares nudae, superne membranula semitectae.
Lingua lacero-emarginata.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 168, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
A giant, periodic flare from the soft gamma repeater SGR1900+14
Creators: name: Hurley, K.
name: Cline, T.
name: Mazets, E.
name: Barthelmy, S.
name: Butterworth, P.
name: Marshall, F.
name: Palmer, D.
name: Aptekar, R.
name: Golenetskii, S.
name: Il'Inskii, V.
name: Frederiks, D.
name: McTiernan, J.
name: Gold, R.
name: Trombka, J.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Soft gamma repeaters are high-energy transient sources associated with neutron stars in young supernova remnants. They emit sporadic, short (~ 0.1 s) bursts with soft energy spectra during periods of intense activity. The event of March 5, 1979 was the most intense and the only clearly periodic one to date. Here we report on an even more intense burst on August 27, 1998, from a different soft gamma repeater, which displayed a hard energy spectrum at its peak, and was followed by a ~300 s long tail with a soft energy spectrum and a dramatic 5.16 s period. Its peak and time integrated energy fluxes at Earth are the largest yet observed from any cosmic source. This event was probably initiated by a massive disruption of the neutron star crust, followed by an outflow of energetic particles rotating with the period of the star. Comparison of these two bursts supports the idea that magnetic energy plays an important role, and that such giant flares, while rare, are not unique, and may occur at any time in the neutron star's activity cycle.
description: Accepted for publication in Nature
Dependence in Propositional Logic: Formula-Formula Dependence and Formula Forgetting -- Application to Belief Update and Conservative Extension
Creators: name: Fang, Liangda
name: Wan, Hai
name: Liu, Xianqiao
name: Fang, Biqing
name: Lai, Zhaorong
Publisher: name: arXiv
Year: 2018
Subjects: subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Dependence is an important concept for many tasks in artificial intelligence. A task can be executed more efficiently by discarding something independent from the task. In this paper, we propose two novel notions of dependence in propositional logic: formula-formula dependence and formula forgetting. The first is a relation between formulas capturing whether a formula depends on another one, while the second is an operation that returns the strongest consequence independent of a formula. We also apply these two notions in two well-known issues: belief update and conservative extension. Firstly, we define a new update operator based on formula-formula dependence. Furthermore, we reduce conservative extension to formula forgetting.
description: We find a mistake in this version and we need a period of time to fix it
The Fragments of Pherecrates’ Agathoi, or the Limits of Reconstruction
Creators: name: Napolitano, Michele
Publisher: name: Fondazione Università Ca’ Foscari Venezia, Italia
Year: 2021

description:

Although only four fragments of Pherecrates’ Agathoi survive, it is still possible, albeit with caution, to imagine that the play was aimed at degenerate aristocrats, to whom the title of the play would refer. To try to prove this, I propose a new, detailed exegesis of three of the four surviving fragments of the play.

description: Lexis
Unveiling MurE ligase potential inhibitors for treating multi-drug resistant Acinetobacter baumannii
Creators: name: Altharawi, Ali
name: Alqahatani, Safar M.
name: Alanazi, Mohammed M.
name: Qamar, Muhammad Tahir ul
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Acinetobacter baumannii is an opportunistic pathogen with ability to cause serious infection such as bacteremia, ventilator associated pneumonia, and wound infections. As strains of A. baumannii are resistant to almost all clinically used antibiotics and with the emergence of carbapenems resistant phenotypes warrants the search for novel antibiotics. Considering this, herein, a series of computer aided drug designing approach was utilized to search novel chemical scaffolds that bind stronger to MurE ligase enzyme of A. baumannii, which is involved peptidoglycan synthesis. The work identified LAS_22461675, LAS_34000090 and LAS_51177972 compounds as promising binding molecules with MurE enzyme having binding energy score of −10.5 kcal/mol, −9.3 kcal/mol and −8.6 kcal/mol, respectively. The compounds were found to achieve docked inside the MurE substrate binding pocket and established close distance chemical interactions. The interaction energies were dominated by van der Waals and less contributions were seen from hydrogen bonding energy. The dynamic simulation assay predicted the complexes stable with no major global and local changes noticed. The docked stability was also validated by MM/PBSA and MM/GBSA binding free energy methods. The net MM/GBSA binding free energy of LAS_22461675 complex, LAS_34000090 complex and LAS_51177972 complex is −26.25 kcal/mol, −27.23 kcal/mol and −29.64 kcal/mol, respectively. Similarly in case of MM-PBSA, the net energy value was in following order; LAS_22461675 complex (−27.67 kcal/mol), LAS_34000090 complex (−29.94 kcal/mol) and LAS_51177972 complex (−27.32 kcal/mol). The AMBER entropy and WaterSwap methods also confirmed stable complexes formation. Further, molecular features of the compounds were determined that predicted compounds to have good druglike properties and pharmacokinetic favorable. The study concluded the compounds to good candidates to be tested by in vivo and in vitro experimental assays. Communicated by Ramaswamy H. Sarma
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VIII, Cart. 192 (11 H 77), 295 folios, f. 0070v
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VIII, Archives départementales de la Côte-d'Or, Cart. 192 (11 H 77), 295 folios, f. 0070v, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VIII, Archives départementales de la Côte-d'Or, Cart. 192 (11 H 77), 295 folios, f. 0070v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Position paper to facilitate patient access to radiopharmaceuticals: considerations for a suitable pharmaceutical regulatory framework
Creators: name: Korde, A
name: Patt, M
name: Selivanova, SV
name: Scott, Andrew
name: Hesselmann, R
name: Kiss, O
name: Ramamoorthy, N
name: Todde, S
name: Rubow, SM
name: Gwaza, L
name: Lyashchenko, S
name: Andersson, J
name: Hockley, B
name: Kaslival, R
name: Decristoforo, C
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 3202
subject: Clinical sciences
classificationCode: 4003
subject: Biomedical engineering

description: Background: Nuclear medicine has made enormous progress in the past decades. However, there are still significant inequalities in patient access among different countries, which could be mitigated by improving access to and availability of radiopharmaceuticals. Main body: This paper summarises major considerations for a suitable pharmaceutical regulatory framework to facilitate patient access to radiopharmaceuticals. These include the distinct characteristics of radiopharmaceuticals which require dedicated regulations, considering the impact of the variable complexity of radiopharmaceutical preparation, personnel requirements, manufacturing practices and quality assurance, regulatory authority interfaces, communication and training, as well as marketing authorisation procedures to ensure availability of radiopharmaceuticals. Finally, domestic and regional supply to ensure patient access via alternative regulatory pathways, including in-house production of radiopharmaceuticals, is described, and an outlook on regulatory challenges faced by new developments, such as the use of alpha emitters, is provided. Conclusions: All these considerations are an outcome of a dedicated Technical Meeting organised by the IAEA in 2023 and represent the views and opinions of experts in the field, not those of any regulatory authorities.
Cognitive, Neuroanatomical, and Genetic Predictors of Executive Function in Healthy Children and Adolescents
Creators: name: Pan, Jessica
name: Sawyer, Kayle
name: EmilyKate McDonough
name: Slotpole, Laura
name: Gansler, David
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Neuroscience
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 111714 Mental Health
subject: FOS: Health sciences

description: The Dimensional Change Card Sort (DCCS) is a measure of cognitive flexibility for children, which requires rule-use and shifting. Demographic, cognitive, regional cortical thickness, and genetic variables, including those related to language and executive function, were used to build predictive models of DCCS scores in 556 healthy pediatric participants. Gender, age, frontal, and temporal lobe regions of interest, and measures of sustained attention, inhibition, and word reading were selected as the best predictors of DCCS performance. Results indicated that DCCS performance is related to a broad range of cognitive functions and anatomic regions associated with various levels of cognitive function.
Cosmological Parameters from Statistics of Strongly Lensed Radio Sources
Creators: name: Cooray, Asantha R.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We calculate the expected number of strongly lensed radio sources in a sample of 6500 sources observed with the Very Large Array as part of the Cosmic Lens All Sky Survey (CLASS) during the first two sessions of its observations. A comparison between the predicted and the observed number of lensed radio sources allows a determination of the current value of Omega-Lambda. If there are six strongly lensed sources in this sample, our 95% confidence upper limit on Lambda in a flat universe is 0.79. Instead of considering a simple cosmological constant, we also consider the possibility of a quintessence scalar field responsible for the additional energy density of the universe. We present our constraints on the Omega_x-w plane. We discuss the region allowed by combined gravitational lensing statistics, high redshift Type Ia supernovae distances, and globular cluster ages. Instead of a cosmological model, we can constrain the redshift distribution of faint radio sources based on the observed gravitational lensing rate and an assumed cosmological model. If there are six strongly lensed sources, the 68% confidence upper limit on the average redshift of radio sources with flux densities less than 150 mJy at 8.4 GHz is < 1.4 + (Omega-Lambda) \pm 0.1. In order to obtain a much tighter estimate on the cosmological parameters, it is essential that the redshift distribution for radio sources at the faint flux density levels be observationally determined. We strongly recommend that statistically complete optical spectroscopic programs be carried out to obtain redshifts for a representative subsample of faint background radio sources.
description: 14 pages, 5 figures, A&A in press
Computational study of inclusion complexes of V-type nerve agents (VE, VG, VM, VR and VX) with β-cyclodextrin
Creators: name: Mahmoudi, Fatemeh
name: Shahraki, Mehdi
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Computational Biology

description: The effective detoxification of organophosphate (OP) nerve agents (OPNAs) is a challenging issue for scientists. The host–guest inclusion complexes of five V-type nerve agents (VE, VG, VM, VR and VX) with β-cyclodextrin (β-CD) have been studied by combining quantum mechanical (QM) calculations and molecular dynamics (MD) simulations. The frontier molecular orbital (FMO) and molecular electrostatic potential (MEP) have been analyzed to describe the reactivity parameters and electronic properties. The obtained results clearly reveal that stable complexes were formed in both vacuum and water media, and the complexation process occurred spontaneously. To understand non-covalent interactions, natural bond orbital (NBO) and quantum theory of atoms in molecules (QTAIM) have been used. IR and Raman spectra have been calculated to confirm the formation of complexes and also thermodynamic parameters have been investigated. It was demonstrated that in addition to van der Waals interactions, the presence of intermolecular hydrogen bonds enhances the stability of these complexes. Furthermore, MD simulations were carried out to get a better insight into the inclusion process of the above complexes. From MD simulations, all simulated systems reached full equilibration at 1000 ps and the V-agent molecules consistently remained in the β-CD cavity and only had vibrational motion inside the cavity. More importantly, MD simulations support the findings of QM calculations and indicate that hydrogen bonding can help the leaving groups of V-agents to be released and them to be hydrolyzed. All results have shown that the VR agent formed the most stable complex with β-CD molecule than that of other agents. Communicated by Ramaswamy H. Sarma
Characterising and modelling fracture in functional pet foods
Creators: name: Skamniotis, Christos
Publisher: name: Imperial College London
Year: 2017

description: The underlying basis of this research is that food oral breakdown heavily depends on the mechanical properties of the material being masticated. So far, researchers have been measuring mechanical properties to establish sensory panels which are useful towards designing food. Although this methodology has proven industrially popular, it displays weakness in addressing complex product development and optimisation tasks. Specifically, mastication involves varying parameters across consumers, such as speed, teeth geometry, bite force, jaw motion, as well as friction. Therefore, this study considers more advanced techniques to help predict how the food will perform during oral processing. A Finite Element (FE) model was developed, where the first bite on a starch based food was simulated, based on digital pet teeth geometry. The food material model was constructed from uniaxial compression and tension data as well as fracture toughness values through the essential work of fracture (EWF) and cutting tests. The main focus is on the development of suitable material constitutive laws including damage, in order to predict deformations and crack patterns in the food item, as experienced during chewing. Emphasis is also given to determining the true material fracture toughness by assessing the validity of the EWF and cutting methods on highly dissipative materials, which leads to the development of a new, more accurate and convenient test method. The composition effect on the mechanical response was also studied by comparing four starch based recipes. The FE jaw force versus displacement results match the experimental data obtained by a physical replicate of the bite model, lending weight to the approach as a powerful tool in understanding food breakdown and in establishing relations between the mechanical properties and sensory attributes. The study also reflects industry needs for time and cost efficient techniques towards product development and optimisation.
Turdus viscivorus Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Passeriformes
Turdidae
Turdus
Turdus viscivorus

description: Turdus viscivorus [spec. nov.]
T. dorso fusco, collo maculis albis, rostro flavescente.
Turdus viscivorus major. Raj. av. 64. n. 1. Will. orn. 137. Aldr. orn. l. 16. c. 1.
Habitat in Europa.
Sibimet ipsi malum cacat disseminator Visci, Ilicisque.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 168, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
ABA+: Assumption-based argumentation with preferences
Creators: name: Cyras, Kristijonas
Publisher: name: Imperial College London
Year: 2017

description: This thesis focuses on using (computational) argumentation theory to model common-sense reasoning with preferences. Common-sense reasoning entails dealing with incomplete, uncertain and conflicting information. Argumentation as a branch of Artificial Intelligence (AI) provides means to reason with such information in a formal way. An important aspect of commonsense reasoning is reasoning with preference information. As such, dealing with preferences is an important phenomenon in argumentation. Through our research, we aim to contribute to the understanding of preference information treatment in argumentation and common-sense reasoning, as well as AI at large. Our objective is to equip a well established structured argumentation formalism - Assumption-Based Argumentation (ABA) - with a new preference handling mechanism. To this end, we propose an extension of ABA, called ABA+, where preferences are accounted for by reversing attacks. This yields a novel way of dealing with preference information in structured argumentation. We also advance a new property concerning contraposition of rules, called Weak Contraposition, applicable to ABA+, and, potentially, to generic approaches to rule-based reasoning with preferences. We argue that ABA+ (with and without Weak Contraposition) exhibits various desirable formal properties concerning argumentation and/or preference handling. We analyse ABA+ in the context of other formalisms of argumentation with preferences and contend advantages of ABA+.
1996/1997 low luminosity state and state transitions of GRS1915+105: RXTE observations
Creators: name: Trudolyubov, S.
name: Churazov, E.
name: Gilfanov, M.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The results of X-ray observations of Galactic superluminal jet source GRS 1915+105 during its low luminosity state and state transitions in October, 1996 - April, 1997 with PCA and HEXTE instruments aboard Rossi X-ray Timing Explorer (RXTE) are reported. Except some peculiarities, the major spectral and temporal properties of the source during this period were similar to that of the Galactic black hole candidates in the intermediate state (corresponding to the transition between the canonical high and low states). The power law component of the spectrum gradually hardens with decrease of the source flux in the 3 - 150 keV energy band. The 2 - 10 Hz QPOs were found to be a generic feature of the power density spectrum in this state. The changes of the QPO centroid frequency are strongly correlated with the changes of spectral and timing parameters (in particular parameters of the soft spectral component). This type of correlation holds on the wide range of time scales (from seconds to months). Overall trend of the spectral and temporal properties suggests that with further drop of the source flux (below the values observed during the reported period) they would match the canonical values for a low state of the Galactic black hole candidates.
description: 34 pages, 14 figures. Submitted to Astronomy Letters
Thermal Radiation at the Nanoscale and Applications
Creators: name: Chapuis, Pierre-Olivier
name: Lee, Bong Jae
name: Rodriguez, Alejandro
Publisher: name: arXiv
Year: 2024
Subjects: subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: There has been a paradigm shift from the well-known laws of thermal radiation derived over a century ago, valid only when the length scales involved are much larger than the thermal wavelength (around 10 $μ$m at room temperature), to a general framework known as fluctuational electrodynamics that allows calculations of radiative heat transfer for arbitrary sizes and length scales. Near-field radiative heat transfer and thermal emission in systems of sub-wavelength size can exhibit super-Planckian behaviour, i.e. flux rates several orders of magnitude larger than that predicted by the Stefan-Boltzmann (or blackbody) limit. These effects can be combined with novel materials, e.g. low-dimensional or topological systems, to yield even larger modifications and spectral and/or directional selectivity. We introduce briefly the context and the main steps that have led to the current boom of ideas and applications. We then discuss the original and impactful works gathered in the associated Special Topic collection, which provides an overview of the flourishing field of nanoscale thermal radiation.
THE CONNECTION OF LEGAL PROTECTION OF GEOGRAPHICAL INDICATIONS AND STATE'S ECONOMIC GROWTH
Creators: name: Almosova, Shahnoza
Publisher: name: Zenodo
Year: 2024

description: Strengthening the connection between territories, their inhabitants and the agricultural and food outputs produced by them is an important in terms of sustainable rural development. This connection arises when products created using local resources can gain special value in the global market due to their continued attachment to their place of origin. Over a time period such products assimilate a certain reputation, associated with their distinctive quality characteristics that are inextricably linked to the place of their production. Science suggests they be called a geographical indication (GI) – as an indicator of a certain geographical territory in all, while legal sciences see it as one of the means of identification of products.
Dictionary Learning for Adaptive GPR Landmine Classification
Creators: name: Giovanneschi, Fabio
name: Mishra, Kumar Vijay
name: Gonzalez-Huici, Maria Antonia
name: Eldar, Yonina C.
name: Ender, Joachim H. G.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Ground penetrating radar (GPR) target detection and classification is a challenging task. Here, we consider online dictionary learning (DL) methods to obtain sparse representations (SR) of the GPR data to enhance feature extraction for target classification via support vector machines. Online methods are preferred because traditional batch DL like K-SVD is not scalable to high-dimensional training sets and infeasible for real-time operation. We also develop Drop-Off MINi-batch Online Dictionary Learning (DOMINODL) which exploits the fact that a lot of the training data may be correlated. The DOMINODL algorithm iteratively considers elements of the training set in small batches and drops off samples which become less relevant. For the case of abandoned anti-personnel landmines classification, we compare the performance of K-SVD with three online algorithms: classical Online Dictionary Learning, its correlation-based variant, and DOMINODL. Our experiments with real data from L-band GPR show that online DL methods reduce learning time by 36-93% and increase mine detection by 4-28% over K-SVD. Our DOMINODL is the fastest and retains similar classification performance as the other two online DL approaches. We use a Kolmogorov-Smirnoff test distance and the Dvoretzky-Kiefer-Wolfowitz inequality for the selection of DL input parameters leading to enhanced classification results. To further compare with state-of-the-art classification approaches, we evaluate a convolutional neural network (CNN) classifier which performs worse than the proposed approach. Moreover, when the acquired samples are randomly reduced by 25%, 50% and 75%, sparse decomposition based classification with DL remains robust while the CNN accuracy is drastically compromised.
description: 16 pages, 11 figures, 10 tables