cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Searching the SETI Ellipsoid with Gaia and TESS
Creators: name: Davenport, James
Publisher: name: Zenodo
Year: 2022

description: Abstract: The SETI Ellipsoid is a geometric method for prioritizing technosignature observations, based on a strategy of receiving signals synchronized to conspicuous astronomical events. Precise distances to nearby stars from Gaia makes constraining Ellipsoid crossing times possible. We use the Gaia Catalog of Nearby Stars to identify targets intersecting the SN 1987A SETI Ellipsoid, as well the Ellipsoids defined by 278 classical novae. Less than 8% of stars within the 100 pc sample are inside the SN 1987A SETI Ellipsoid, meaning the vast majority of nearby stars are still viable targets to monitor for coordinated signals! We find an average of 734 stars per year within the 100 pc volume will intersect the Ellipsoid from SN 1987A, with ~10% of those having distance uncertainties from Gaia better than 0.1 lyr. Finally I will discuss how this framework can be implemented with surveys like TESS and eventually LSST.
The relationship between human capital and environmental destruction: the case of European countries
Creators: name: Yildiz, Tuba
name: Arslan, Ünal
name: Çeliköz, Yıldız Sağlam
name: Yildiz, Tuba
name: Arslan, Ünal
name: Çeliköz, Yıldız Sağlam
Publisher: name: Unknown
Year: 2022
Subjects: subject: Environmental Economics and Policy
subject: Labor and Human Capital
subject: ecological footprint
subject: environment
subject: human capital
subject: economic growth
subject: European countries

description: Purpose. This study aims to examine the relationship between human capital and environmental destruction. Methodology / approach. The analysis includes 56 years between 1961 and 2017 for 14 selected European countries. In the model established for the variables, the ecological footprint is used as the dependent variable, human capital and real national income per capita are used as independent variables. To select the appropriate test method in the analysis, we used the CADF panel unit root test, which considers the cross-sectional dependence. The Pooled Mean Group was used for model estimation. Results. In the study, it is emphasized that human capital has an important contribution to reducing the ecological footprint as an indicator of environmental pollution. According to the results of the PMG co-integration analysis, the increase in human capital reduces the ecological footprint in European countries. Since the European countries are developed ones, the availability of a good educational infrastructure is an important factor. It increases human capital. In addition, the high level of education and welfare in European countries is effective in increasing the number of environmentally sensitive individuals. This increases the environmental quality and therefore is an important factor in reducing the ecological footprint. Originality / scientific novelty. There are no studies in the literature examining the relationship between human capital and the ecological footprint of European countries. Therefore, this study closes a gap in the literature and takes its originality from the relationship between human capital and ecological footprint in European countries. Practical value / implications. The practical value of the results is that human capital reduces the ecological footprint by protecting natural resources, exhibiting a more environmentally friendly behavior, and realizing production that will minimize the damage to the environment.
Association of Simulated COVID-19 Vaccination and Nonpharmaceutical Interventions With Infections, Hospitalizations, and Mortality
Creators: name: Swann, Julie L.
name: Rosenstrom, Erik
name: Boyce, Ross M.
name: Hassmiller Lich, Kristen
name: Keskinocak, Pinar
name: Ivy, Julie S.
name: Johnson, Karl T.
name: Mayorga, Maria E.
name: Delamater, Paul L.
name: Smith, Raymond L.
name: Patel, Mehul D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: IMPORTANCE Vaccination against SARS-CoV-2 has the potential to significantly reduce transmission and COVID-19 morbidity and mortality. The relative importance of vaccination strategies and nonpharmaceutical interventions (NPIs) is not well understood. OBJECTIVE To assess the association of simulated COVID-19 vaccine efficacy and coverage scenarios with and without NPIs with infections, hospitalizations, and deaths. DESIGN, SETTING, AND PARTICIPANTS An established agent-based decision analytical model was used to simulate COVID-19 transmission and progression from March 24, 2020, to September 23, 2021. The model simulated COVID-19 spread in North Carolina, a US state of 10.5 million people. A network of 1 017 720 agents was constructed from US Census data to represent the statewide population. EXPOSURES Scenarios of vaccine efficacy (50% and 90%), vaccine coverage (25%, 50%, and 75% at the end of a 6-month distribution period), and NPIs (reduced mobility, school closings, and use of face masks) maintained and removed during vaccine distribution. MAIN OUTCOMES AND MEASURES Risks of infection from the start of vaccine distribution and risk differences comparing scenarios. Outcome means and SDs were calculated across replications. RESULTS In the worst-case vaccination scenario (50% efficacy, 25%coverage), a mean (SD) of 2 231 134 (117 867) new infections occurred after vaccination began with NPIs removed, and a mean (SD) of 799 949 (60 279) new infections occurred with NPIs maintained during 11 months. In contrast, in the best-case scenario (90% efficacy, 75%coverage), a mean (SD) of 527 409 (40 637) new infections occurred with NPIs removed and a mean (SD) of 450 575 (32 716) new infections occurred with NPIs maintained. With NPIs removed, lower efficacy (50%) and higher coverage (75%) reduced infection risk by a greater magnitude than higher efficacy (90%) and lower coverage (25%) compared with theworst-case scenario (mean [SD] absolute risk reduction, 13%[1%] and 8%[1%], respectively). CONCLUSIONS AND RELEVANCE Simulation outcomes suggest that removing NPIs while vaccines are distributed may result in substantial increases in infections, hospitalizations, and deaths. Furthermore, as NPIs are removed, higher vaccination coverage with less efficacious vaccines can contribute to a larger reduction in risk of SARS-CoV-2 infection compared with more efficacious vaccines at lower coverage. These findings highlight the need for well-resourced and coordinated efforts to achieve high vaccine coverage and continued adherence to NPIs before many prepandemic activities can be resumed.
Structural instability of the rutile compounds and its relevance to the metal-insulator transition of VO2
Creators: name: Hiroi, Zenji
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The metal-insulator transition (MIT) of VO2 is discussed with particular emphasis on the structural instability of the rutile compounds toward dimerization. Ti substitution experiments reveal that the MIT is robust up to 20% Ti substitutions and occurs even in extremely thin V-rich lamellas in spinodally decomposed TiO2-VO2 composites, indicating that the MIT is insensitive to hole doping and essentially takes on a local character. These observations suggest that either electron correlation in the Mott-Hubbard sense or Peierls (Fermi-surface) instability plays a minor role on the MIT. Through a broad perspective of crystal chemistry on the rutile-related compounds, it is noted that VO2 and another MIT compound NbO2 in the family eventually lie just near the borderline between the two structural groups with the regular rutile structure and the distorted structures characterized by the formation of dimers with direct metal-metal bonding. The MITs of VO2 and NbO2 are natural consequences of structural transitions between the two groups, as all the d electrons are trapped in the bonding molecular orbitals of dimers at low temperatures. Such dimer crystals are ubiquitously found in early transition metal compounds having chain-like structures, such as MoBr3, NbCl4, Ti4O7, and V4O7, the latter two of which also exhibit MITs probably of the same origin. In a broader sense, the dimer crystal is a kind of molecular orbital crystals in which virtual molecules made of transition metal atoms with partially-filled t2g shells, such as dimers, trimers or larger ones, are generated by metal-metal bonding and are embedded into edge- or face-sharing octahedron networks of various kinds. The molecular orbital crystallization opens a natural route to stabilization of unpaired t2g electrons in crystals.
description: 29 pages, 23 figures, 5 tables
(3678) Lucy Goodchild
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(3674) Edward Searle
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Quantum Coherence: Reciprocity and Distribution
Creators: name: Kumar, Asutosh
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum coherence is the outcome of the superposition principle. Recently, it has been theorized as a quantum resource, and is the premise of quantum correlations in multipartite systems. It is therefore interesting to study the coherence content and its distribution in a multipartite quantum system. In this work, we show analytically as well as numerically the reciprocity between coherence and mixedness of a quantum state. We find that this trade-off is a general feature in the sense that it is true for large spectra of measures of coherence and of mixedness. We also study the distribution of coherence in multipartite systems by looking at monogamy-type relation--which we refer to as additivity relation--between coherences of different parts of the system. We show that for the Dicke states, while the normalized measures of coherence violate the additivity relation, the unnormalized ones satisfy the same.
description: 8 pages, 3 figures, 1 table, published version
(3676) Peter Stanhope Baines
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 1 of Non-adherence to inhaled medications among adult asthmatic patients in Ethiopia: a systematic review and meta-analysis
Creators: name: Woldu Aberhe
name: Abrha Hailay
name: Kidane Zereabruk
name: Guesh Mebrahtom
name: Teklehaimanot Haile
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1.
Verbatim MME methods from studies cited in the CDC pain Guideline
Creators: name: Dasgupta, Nabarun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: Verbatim extracts of methods used in the evidence base cited in the 2016 CDC Guideline for chronic non-cancer pain with opioids. 

Source documentation:
Ranapurwala SI, Naumann RB, Austin AE, Dasgupta N, Marshall SW. Methodologic limitations of prescription opioid safety research and recommendations for improving the evidence base. Pharmacoepidemiol Drug Saf. 2019 Jan;28(1):4-12. doi: 10.1002/pds.4564. Epub 2018 Jun 3. PMID: 29862602.
(3671) Thomas Russell Maltby
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Overlooking: Experimenting with Collaboration for Justice-Driven Journalistic Practice
Creators: name: Rea, Andie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020
Subjects: Journalism--Objectivity
Social justice

description: For the project, I will explore two different reporting processes to see if and how sharing editorial agency and control with sources changes journalistic practice. I will analyze the power-dynamic inherent in the dichotomy between “reporter” and “reported” and seek to answer how I will choose to practice the ethic of journalistic independence, especially as a person of privilege. I will apply two different reporting approaches to create two video stories. These different approaches will examine the ways shared editorial power with the people at the center of a story alters the gathering, documenting, and reporting of a story. 

I will then contrast these processes, their resulting video products, and the impact on those whose stories are shared. I will use what I have learned to construct a personal storytelling ethic that centralizes telling important true stories and getting people to pay attention to them—while acknowledging the limits and risks inherent in sharing a story that is not my own.
Heegner divisors in generalized Jacobians and traces of singular moduli
Creators: name: Bruinier, Jan Hendrik
name: Li, Yingkun
Publisher: name: arXiv
Year: 2015
Subjects: subject: Number Theory (math.NT)
subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14G35, 14H40, 11F27, 11F30

description: We prove an abstract modularity result for classes of Heegner divisors in the generalized Jacobian of a modular curve associated to a cuspidal modulus. Extending the Gross-Kohnen-Zagier theorem, we prove that the generating series of these classes is a weakly holomorphic modular form of weight 3/2. Moreover, we show that any harmonic Maass forms of weight 0 defines a functional on the generalized Jacobian. Combining these results, we obtain a unifying framework and new proofs for the Gross-Kohnen-Zagier theorem and Zagier's modularity of traces of singular moduli, together with new geometric interpretations of the traces with non-positive index.
description: 21 pages
(3672) Alan Guy Fishwick Leather
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(3675) Deborah Kellaway
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Physics of Giant ElectroMagnetic Pulse generation in short pulse laser experiments
Creators: name: Poyé, Alexandre
name: Hulin, Sébastien
name: Bailly-Grandvaux, Mathieu
name: Dubois, Jean-Luc
name: Ribolzi, Jérôme
name: Raffestin, Didier
name: Bardon, Matthieu
name: Lubrano-Lavaderci, Frédéric
name: D'Humières, Emmanuel
name: Santos, Joao Jorge
name: Nicolaï, Philippe
name: Tikhonchuk, Vladimir
Publisher: name: arXiv
Year: 2015
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: In this paper we describe the physical processes that lead to the generation of Giant Electro- Magnetic Pulses (GEMP) on powerful laser facilities. Our study is based on experimental mea- surements of both the charging of a solid target irradiated by an ultra-short, ultra-intense laser and the detection of the electromagnetic emission in the GHz domain. An unambiguous correlation between the neutralisation current in the target holder and the electromagnetic emission shows that the source of the GEMP is the remaining positive charge inside the target after the escape of fast electrons accelerated by the ultra-intense laser. A simple model for calculating this charge in the thick target case is presented. From this model and knowing the geometry of the target holder, it becomes possible to estimate the intensity and the dominant frequencies of the GEMP on any facility.
Increased burden of ultra-rare structural variants localizing to boundaries of topologically associated domains in schizophrenia
Creators: name: Halvorsen, M.
name: Ameur, A.
name: Li, Y.
name: Hultman, C.M.
name: Giusti-Rodriguez, P.
name: Wen, J.
name: Crowley, J.J.
name: Huh, R.
name: Bryois, J.
name: Farrell, M.
name: Karlsson, R.
name: Szatkiewicz, J.P.
name: Gyllensten, U.
name: Ancalade, N.E.,
name: Netotea, S.
name: Oskolkov, N.
name: Nystedt, B.
name: Magnusson, P.K.E.
name: Sullivan, P.F.
name: Kähler, A.K.
Publisher: name: Nature Research
Year: 2020

description: Despite considerable progress in schizophrenia genetics, most findings have been for large rare structural variants and common variants in well-imputed regions with few genes implicated from exome sequencing. Whole genome sequencing (WGS) can potentially provide a more complete enumeration of etiological genetic variation apart from the exome and regions of high linkage disequilibrium. We analyze high-coverage WGS data from 1162 Swedish schizophrenia cases and 936 ancestry-matched population controls. Our main objective is to evaluate the contribution to schizophrenia etiology from a variety of genetic variants accessible to WGS but not by previous technologies. Our results suggest that ultra-rare structural variants that affect the boundaries of topologically associated domains (TADs) increase risk for schizophrenia. Alterations in TAD boundaries may lead to dysregulation of gene expression. Future mechanistic studies will be needed to determine the precise functional effects of these variants on biology.
Antipsychotic behavioral phenotypes in the mouse collaborative cross recombinant inbred inter-crosses (RIX)
Creators: name: Quackenbush, C.R.
name: de Villena, F.P.M.
name: Xenakis, J.G.
name: Nonneman, R.J.
name: Giusti-Rodríguez, P.
name: Ryan, A.
name: Zou, F.
name: Crowley, J.J.
name: Shaw, G.D.
name: Zhabotynsky, V.
name: Sullivan, P.F.
name: Miller, D.R.
name: DeCristo, D.M.
Publisher: name: Genetics Society of America
Year: 2020

description: Schizophrenia is an idiopathic disorder that affects approximately 1% of the human population, and presents with persistent delusions, hallucinations, and disorganized behaviors. Antipsychotics are the standard pharmacological treatment for schizophrenia, but are frequently discontinued by patients due to inefficacy and/or side effects. Chronic treatment with the typical antipsychotic haloperidol causes tardive dyskinesia (TD), which manifests as involuntary and often irreversible orofacial movements in around 30% of patients. Mice treated with haloperidol develop many of the features of TD, including jaw tremors, tongue protrusions, and vacuous chewing movements (VCMs). In this study, we used genetically diverse Collaborative Cross (CC) recombinant inbred inter-cross (RIX) mice to elucidate the genetic basis of antipsychotic-induced adverse drug reactions (ADRs). We performed a battery of behavioral tests in 840 mice from 73 RIX lines (derived from 62 CC strains) treated with haloperidol or placebo in order to monitor the development of ADRs. We used linear mixed models to test for strain and treatment effects. We observed highly significant strain effects for almost all behavioral measurements investigated (P≺ 0.001). Further, we observed strong strain-by-treatment interactions for most phenotypes, particularly for changes in distance traveled, vertical activity, and extrapyramidal symptoms (EPS). Estimates of overall heritability ranged from 0.21 (change in body weight) to 0.4 (VCMs and change in distance traveled) while the portion attributable to the interactions of treatment and strain ranged from 0.01 (for change in body weight) to 0.15 (for change in EPS). Interestingly, close to 30% of RIX mice exhibited VCMs, a sensitivity to haloperidol exposure, approximately similar to the rate of TD in humans chronically exposed to haloperidol. Understanding the genetic basis for the susceptibility to antipsychotic ADRs may be possible in mouse, and extrapolation to humans could lead to safer therapeutic approaches for schizophrenia.
Robust Hi-C Maps of Enhancer-Promoter Interactions Reveal the Function of Non-coding Genome in Neural Development and Diseases
Creators: name: Rong, Z.
name: Giusti-Rodríguez, P.
name: Kawaguchi, R.
name: Sullivan, P.F.
name: Zhang, S.
name: Cui, J.
name: Wen, Z.
name: Song, H.
name: Xu, Z.
name: Ma, S.
name: Liu, X.
name: Jin, F.
name: Xu, W.
name: Lu, L.
name: Li, Y.
name: Scacheri, P.C.
name: Ming, G.-L.
name: Huang, W.-K.
name: Li, Y.
name: Bartels, C.F.
name: Hu, M.
name: Rosen, J.D.
Publisher: name: Cell Press
Year: 2020

description: Genome-wide mapping of chromatin interactions at high resolution remains experimentally and computationally challenging. Here we used a low-input “easy Hi-C” protocol to map the 3D genome architecture in human neurogenesis and brain tissues and also demonstrated that a rigorous Hi-C bias-correction pipeline (HiCorr) can significantly improve the sensitivity and robustness of Hi-C loop identification at sub-TAD level, especially the enhancer-promoter (E-P) interactions. We used HiCorr to compare the high-resolution maps of chromatin interactions from 10 tissue or cell types with a focus on neurogenesis and brain tissues. We found that dynamic chromatin loops are better hallmarks for cellular differentiation than compartment switching. HiCorr allowed direct observation of cell-type- and differentiation-specific E-P aggregates spanning large neighborhoods, suggesting a mechanism that stabilizes enhancer contacts during development. Interestingly, we concluded that Hi-C loop outperforms eQTL in explaining neurological GWAS results, revealing a unique value of high-resolution 3D genome maps in elucidating the disease etiology.
How Might Technologically Advanced Civilization Spread Through the Galaxy
Creators: name: Carroll-Nellenback, Jonathan
Publisher: name: Zenodo
Year: 2022

description: Abstract: We model the settlement of the galaxy by space-faring civilizations of varying levels of technological sophistication in order to understand how the local density of habitable worlds (as well as mean civilization lifetimes) might effect the level of technological sophistication in various regions of the galaxy. We model the technological development of a civilization to be an Ornstein-Uhlenbeck (OU) process and tie the level of technology to the range of interstellar travel. We find that the level of technological sophistication tends to evolve (when possible) to one necessary to maintain modest levels of settlement. We interpret this as a balance of selection pressure and the tendency of the technology to revert to the mean. This might indicate more advanced civilizations to likely exist near the periphery of the galaxy where advanced technology is needed to colonize neighboring systems.
Additional file 3 of States with fewer criminalizing immigrant policies have smaller health care inequities between citizens and noncitizens
Creators: name: Young, Maria-Elena De Trinidad
name: Hiram Beltrán-Sánchez
name: Wallace, Steven P.
Publisher: name: figshare
Year: 2020
Subjects: subject: Sociology
subject: FOS: Sociology

description: Additional file 3. Predicted probability of having a usual source of care across levels of criminalization
(3673) Charles William Kellaway
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 1 of Low concentration effects and different outcome in repeated reproduction tests with silver nanoparticles, silver nitrate and Folsomia candida (Collembola)
Creators: name: Zhang, Xin
name: Filser, Juliane
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Neuroscience
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Tables S1–S6.
Non-coding variability at the APOE locus contributes to the Alzheimer’s risk
Creators: name: Fu, A.K.Y.
name: Kwok, T.C.Y.
name: Mok, V.C.T.
name: Ip, F.C.
name: Sullivan, P.F.
name: Mullapudi, N.
name: Hardy, J.
name: Chen, Y.
name: Giusti-Rodríguez, P.
name: Chen, Y.
name: Alzheimer's Disease Neuroimaging Initiative
name: Li, Y.
name: Mok, K.Y.
name: Ip, N.Y.
name: Zhou, X.
name: Guo, Q.
Publisher: name: Nature Publishing Group
Year: 2019

description: Alzheimer’s disease (AD) is a leading cause of mortality in the elderly. While the coding change of APOE-ε4 is a key risk factor for late-onset AD and has been believed to be the only risk factor in the APOE locus, it does not fully explain the risk effect conferred by the locus. Here, we report the identification of AD causal variants in PVRL2 and APOC1 regions in proximity to APOE and define common risk haplotypes independent of APOE-ε4 coding change. These risk haplotypes are associated with changes of AD-related endophenotypes including cognitive performance, and altered expression of APOE and its nearby genes in the human brain and blood. High-throughput genome-wide chromosome conformation capture analysis further supports the roles of these risk haplotypes in modulating chromatin states and gene expression in the brain. Our findings provide compelling evidence for additional risk factors in the APOE locus that contribute to AD pathogenesis.
Comment on Article by Berger, Bernardo, and Sun
Creators: name: Mendoza, Manuel
name: Gutiérrez-Peña, Eduardo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics

description: Discussion of Overall Objective Priors by James O. Berger, Jose M. Bernardo, Dongchu Sun [arXiv:1504.02689].
description: Published at http://dx.doi.org/10.1214/14-BA936 in the Bayesian Analysis (http://projecteuclid.org/euclid.ba) by the International Society of Bayesian Analysis (http://bayesian.org/)
Helium signature in red giant oscillation patterns observed by Kepler
Creators: name: Vrard, M.
name: Mosser, B.
name: Barban, C.
name: Belkacem, K.
name: Elsworth, Y.
name: Kallinger, T.
name: Hekker, S.
name: Samadi, R.
name: Beck, P. G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The space-borne missions CoRoT and Kepler have provided a large amount of precise photometric data. Among the stars observed, red giants show a rich oscillation pattern that allows their precise characterization. Long-duration observations allow for investigating the fine structure of this oscillation pattern. A common pattern of oscillation frequency was observed in red giant stars, which corresponds to the second-order development of the asymptotic theory. This pattern, called the universal red giant oscillation pattern, describes the frequencies of stellar acoustic modes. We aim to investigate the deviations observed from this universal pattern, thereby characterizing them in terms of the location of the second ionization zone of helium. We also show how this seismic signature depends on stellar evolution. We measured the frequencies of radial modes with a maximum likelihood estimator method, then we identified a modulation corresponding to the departure from the universal oscillation pattern. We identify the modulation component of the radial mode frequency spacings in more than five hundred red giants. The variation in the modulation that we observe at different evolutionary states brings new constraints on the interior models for these stars. We also derive an updated form of the universal pattern that accounts for the modulation and provides highly precise radial frequencies.
description: 10 pages, 9 figures, accepted by A&A. AA/2014/25064
Scribability problems for polytopes
Creators: name: Chen, Hao
name: Padrol, Arnau
Publisher: name: arXiv
Year: 2015
Subjects: subject: Metric Geometry (math.MG)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: In this paper we study various scribability problems for polytopes. We begin with the classical $k$-scribability problem proposed by Steiner and generalized by Schulte, which asks about the existence of $d$-polytopes that cannot be realized with all $k$-faces tangent to a sphere. We answer this problem for stacked and cyclic polytopes for all values of $d$ and $k$. We then continue with the weak scribability problem proposed by Grünbaum and Shephard, for which we complete the work of Schulte by presenting non weakly circumscribable $3$-polytopes. Finally, we propose new $(i,j)$-scribability problems, in a strong and a weak version, which generalize the classical ones. They ask about the existence of $d$-polytopes that can not be realized with all their $i$-faces "avoiding" the sphere and all their $j$-faces "cutting" the sphere. We provide such examples for all the cases where $j-i \le d-3$.
description: 25 pages, 11 figures. v2: minor changes
Detecting intraday financial market states using temporal clustering
Creators: name: Hendricks, Dieter
name: Gebbie, Tim
name: Wilcox, Diane
Publisher: name: arXiv
Year: 2015
Subjects: subject: Trading and Market Microstructure (q-fin.TR)
subject: Computational Finance (q-fin.CP)
subject: FOS: Economics and business

description: We propose the application of a high-speed maximum likelihood clustering algorithm to detect temporal financial market states, using correlation matrices estimated from intraday market microstructure features. We first determine the ex-ante intraday temporal cluster configurations to identify market states, and then study the identified temporal state features to extract state signature vectors which enable online state detection. The state signature vectors serve as low-dimensional state descriptors which can be used in learning algorithms for optimal planning in the high-frequency trading domain. We present a feasible scheme for real-time intraday state detection from streaming market data feeds. This study identifies an interesting hierarchy of system behaviour which motivates the need for time-scale-specific state space reduction for participating agents.
description: 30 pages, 16 figures, 8 tables, published in Quantitative Finance
RNA-seq data and ChIP-seq data
Creators: name: 王丹丹(Dandan Wang)
Publisher: name: CNGB
Year: 2022
Subjects: Raw sequence reads
Other
Chinese Bama pig tissues
Agricultural

description: RNA-seq data of five tissues, including muscle, lung, spleen, lymph and tonsil tissues. 2. ChIP-seq data of Chinese Bama pig liver and muscle using anti-ZBED6 antibody.
Spacelike and Timelike Admissible Smarandache Curves in Pseudo-Galilean Space
Creators: name: Saad, M. Khalifa
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 53A35, 53B30

description: In this paper, space and timelike admissible Smarandache curves in the pseudo- Galilean 3-space are investigated. Also, Smarandache curves of the position vector of space and timelike arbitrary curve and some of its special curves in the pseudo- Galilean 3-space are obtained. To confirm our main results, some examples are given and illustrated.
description: 19 pages, 20 figures
Codes on Binocular Rivalry Impact on Error Concealment for S3D Video
Creators: name: Hasan, Md Mehedi
Publisher: name: figshare
Year: 2022
Subjects: subject: Computer Engineering
subject: 80104 Computer Vision
subject: FOS: Computer and information sciences

description: Experimental Codes for Simulating transmission error, error propagation and analysis of the macroblock losses in the video frames. The codes are organized ab below: 1. Frame Extraction 2. Create Video 3. Simuloss 4. ChannelError Simulation 5. Concealment_CAD 6. Concealment_VC 7. SubjMeasure_MRF 8. SubjMeasure_QAM 9. Figure_Chart 10.Other Loss Experiments
Common-variant associations with fragile X syndrome
Creators: name: Stockmeier, C.A.
name: Carr, J.L.
name: Giusti-Rodriguez, P.
name: Sullivan, P.F.
name: Crawford, G.E.
name: Taylor, A.K.
name: Booker, J.K.
name: Crowley, J.J.
name: Piven, J.
name: Ancalade, N.E.
name: Losh, M.
name: Kähler, A.K.
name: Szatkiewicz, J.
Publisher: name: Nature Publishing Group
Year: 2019

description: Fragile X syndrome is rare but a prominent cause of intellectual disability. It is usually caused by a de novo mutation that occurs on multiple haplotypes and thus would not be expected to be detectible using genome-wide association (GWA). We conducted GWA in 89 male FXS cases and 266 male controls, and detected multiple genome-wide significant signals near FMR1 (odds ratio = 8.10, P = 2.5 × 10 −10 ). These findings withstood robust attempts at falsification. Fine-mapping yielded a minimum P = 1.13 × 10 −14 , but did not narrow the interval. Comprehensive functional genomic integration did not provide a mechanistic hypothesis. Controls carrying a risk haplotype had significantly longer FMR1 CGG repeats than controls with the protective haplotype (P = 4.75 × 10 −5 ), which may predispose toward increases in CGG number to the premutation range over many generations. This is a salutary reminder of the complexity of even “simple” monogenetic disorders.
(3667) Sylvia Wynn Tennant
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Integrative functional genomic analysis of human brain development and neuropsychiatric risks
Creators: name: Lorente-Galdos, B.
name: Kang, H.J.
name: Sestan, N.
name: Geschwind, D.H.
name: Evgrafov, O.V.
name: Xu, X.
name: Gulden, F.O.
name: Giusti-Rodríguez, P.
name: Zhu, Y.
name: Gerstein, M.B.
name: Werling, D.M.
name: Sunkin, S.M.
name: Pochareddy, S.
name: De Leeuw, C.A.
name: Jin, F.
name: Pletikos, M.
name: Santpere, G.
name: Muchnik, S.
name: Knowles, J.A.
name: Kawasawa, Y.I.
name: Walters, J.T.R.
name: Posthuma, D.
name: Li, Y.
name: Owen, M.J.
name: Li, M.
name: Weinberger, D.R.
name: Won, H.
name: Choi, J.
name: Levitt, P.
name: BrainSpan Consortium
name: PsychENCODE Consortium
name: PsychENCODE Developmental Subgroup
name: Hu, M.
name: Sanders, S.J.
name: Hyde, T.M.
name: Lein, E.S.
name: State, M.W.
name: Shin, Y.
name: Sousa, A.M.M.
name: Liu, S.
name: Li, Z.
name: Kleinman, J.E.
name: Hawrylycz, M.J.
name: Wang, D.
name: Pardiñas, A.F.
name: Kitchen, R.R.
name: Sullivan, P.F.
name: O'Donovan, M.C.
Publisher: name: American Association for the Advancement of Science
Year: 2018

description: To broaden our understanding of human neurodevelopment, we profiled transcriptomic and epigenomic landscapes across brain regions and/or cell types for the entire span of prenatal and postnatal development. Integrative analysis revealed temporal, regional, sex, and cell type-specific dynamics.We observed a global transcriptomic cup-shaped pattern, characterized by a late fetal transition associated with sharply decreased regional differences and changes in cellular composition and maturation, followed by a reversal in childhood-adolescence, and accompanied by epigenomic reorganizations. Analysis of gene coexpression modules revealed relationships with epigenomic regulation and neurodevelopmental processes. Genes with genetic associations to brain-based traits and neuropsychiatric disorders (including MEF2C, SATB2, SOX5, TCF4, and TSHZ3) converged in a small number of modules and distinct cell types, revealing insights into neurodevelopment and the genomic basis of neuropsychiatric risks.
(3668) Robert Tennant (jun)
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Network heterogeneity and node capacity lead to heterogeneous scaling of fluctuations in random walks on graphs
Creators: name: Kosmidis, Kosmas
name: Beber, Moritz
name: Hütt, Marc-Thorsten
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Random walks are one of the best investigated dynamical processes on graphs. A particularly fascinating phenomenon is the scaling relationship of fluctuations $σ$ with the average flux $\langle f \rangle $. Here we analyze how network topology and nodes with finite capacity lead to deviations from a simple scaling law $σ\sim \langle f \rangle ^α$. Sources of randomness are the random walk itself (internal noise) and the fluctuation of the number of walkers (external noise). We obtained exact results for the extreme case of a star network which are indicative of the behavior of large scale systems with a broad degree distribution.The latter are subsequently studied using Monte Carlo simulations. We find that the network heterogeneity amplifies the effects of external noise. By computing the `effective' scaling of each node we show that multiple scaling relationships can coexist in a graph with a heterogeneous degree distribution at an intermediate level of external noise. Finally, we analyze the effect of a finite capacity of nodes for random walkers and find that this also can lead to a heterogeneous scaling of fluctuations.
description: 12 pages, 11 figures
Short-period X-ray oscillations in super-soft novae and persistent SSS
Creators: name: Ness, J. -U.
name: Beardmore, A. P.
name: Osborne, J. P.
name: Kuulkers, E.
name: Henze, M.
name: Piro, A. L.
name: Drake, J. J.
name: Dobrotka, A.
name: Schwarz, G.
name: Starrfield, S.
name: Kretschmar, P.
name: Hirsch, M.
name: Wilms, J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Transient short-period <100s oscillations have been found in the X-ray light curves of three novae during their SSS phase and in one persistent SSS. We pursue an observational approach to determine possible driving mechanisms and relations to fundamental system parameters such as the white dwarf mass. We performed a systematic search for short-period oscillations in all available XMM-Newton and Chandra X-ray light curves of persistent SSS and novae during their SSS phase. To study time evolution, we divided each light curve into short time segments and computed power spectra. We then constructed dynamic power spectra from which we identified transient periodic signals even when only present for a short time. From all time segments of each system, we computed fractions of time when periodic signals were detected. In addition to the previously known systems with short-period oscillations, RS Oph (35s), KT Eri (35s), V339 Del (54s), and Cal 83 (67s), we found one additional system, LMC 2009a (33s), and also confirm the 35s period from Chandra data of KT Eri. The amplitudes of oscillations are of order <15% of the respective count rates and vary without any clear dependence on the X-ray count rate. The fractions of the time when the respective periods were detected at 2-sigma significance (duty cycle) are 11.3%, 38.8%, 16.9%, 49.2%, and 18.7% for LMC 2009a, RS Oph, KT Eri, V339 Del, and Cal 83, respectively. The respective highest duty cycles found in a single observation are 38.1%, 74.5%, 61.4%, 67.8%, and 61.8%.
description: accepted for publication in A&A
Evaluation of chromatin accessibility in prefrontal cortex of individuals with schizophrenia
Creators: name: Safi, A.
name: Buil, A.
name: Giusti-Rodriguez, P.
name: Shieh, A.W.
name: Wray, G.A.
name: Akbarian, S.
name: Sullivan, P.F.
name: Garrett, M.E.
name: Haroutunian, V.
name: Sklar, P.
name: Johnson, G.D.
name: Reddy, T.E.
name: Ashley-Koch, A.
name: Liu, C.
name: Bryois, J.
name: Roussos, P.
name: Stockmeier, C.A.
name: Song, L.
name: Crawford, G.E.
name: Fullard, J.F.
name: White, K.P.
Publisher: name: Nature Publishing Group
Year: 2018

description: Schizophrenia genome-wide association studies have identified >150 regions of the genome associated with disease risk, yet there is little evidence that coding mutations contribute to this disorder. To explore the mechanism of non-coding regulatory elements in schizophrenia, we performed ATAC-seq on adult prefrontal cortex brain samples from 135 individuals with schizophrenia and 137 controls, and identified 118,152 ATAC-seq peaks. These accessible chromatin regions in the brain are highly enriched for schizophrenia SNP heritability. Accessible chromatin regions that overlap evolutionarily conserved regions exhibit an even higher heritability enrichment, indicating that sequence conservation can further refine functional risk variants. We identify few differences in chromatin accessibility between cases and controls, in contrast to thousands of age-related differential accessible chromatin regions. Altogether, we characterize chromatin accessibility in the human prefrontal cortex, the effect of schizophrenia and age on chromatin accessibility, and provide evidence that our dataset will allow for fine mapping of risk variants.