cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
(400870) William Byers Neave
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
c-Jun N-terminal kinase 2 prevents luminal cell commitment in normal mammary glands and tumors by inhibiting p53/Notch1 and breast cancer gene 1 expression
Creators: name: Pfefferle, Adam D.
name: Van Den Berg, Carla Lynn
name: Ebelt, Nancy D.
name: Perou, Charles M.
name: Cantrell, Michael A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Breast cancer is a heterogeneous disease with several subtypes carrying unique prognoses. Patients with differentiated luminal tumors experience better outcomes, while effective treatments are unavailable for poorly differentiated tumors, including the basal-like subtype. Mechanisms governing mammary tumor subtype generation could prove critical to developing better treatments. C-Jun N-terminal kinase 2 (JNK2) is important in mammary tumorigenesis and tumor progression. Using a variety of mouse models, human breast cancer cell lines and tumor expression data, studies herein support that JNK2 inhibits cell differentiation in normal and cancer-derived mammary cells. JNK2 prevents precocious pubertal mammary development and inhibits Notch-dependent expansion of luminal cell populations. Likewise, JNK2 suppresses luminal populations in a p53-competent Polyoma Middle T-antigen tumor model where jnk2 knockout causes p53-dependent upregulation of Notch1 transcription. In a p53 knockout model, JNK2 restricts luminal populations independently of Notch1, by suppressing Brca1 expression and promoting epithelial to mesenchymal transition. JNK2 also inhibits estrogen receptor (ER) expression and confers resistance to fulvestrant, an ER inhibitor, while stimulating tumor progression. These data suggest that therapies inhibiting JNK2 in breast cancer may promote tumor differentiation, improve endocrine therapy response, and inhibit metastasis.
Technology, experimentation, and use of resources: rehabilitation of Modern architectural projects
Creators: name: Ascione, Paola
Publisher: name: TECHNE - Journal of Technology for Architecture and Environment
Year: 2017

description: Experiences in energy upgrading for Modern heritage demonstrate that the simple reapplication of general practice risks losing an overall conception of the built work, including in cases where the original project drew on resource-optimisation criteria similar to the current requirements for environmental sustainability. The present study examines this context, drawing on two programs of applied research: the first concerning materials and Modern architectural design under Italian “autarchy”; the second concerning more general problems of sustainable rehabilitation for 20th century heritage properties. The two programs share a research methodology in which the knowledge-building stage extends to interpretation of the construction, in terms of the “technological culture” of the original architectural planning.
description: TECHNE - Journal of Technology for Architecture and Environment, TECHNE 13 (2017): Theories Practice Design
D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth
Creators: name: Li, Tingting
name: Xia, Yukun
name: Deng, Wanglong
name: Gu, Zhong Kai
name: Ma, Shenghong
name: Wu, Fei Zhen
name: Yang, Hui
name: Xiong, Yue
name: Ye, Dan
name: Jiang, Bowen
name: Guan, Kun Liang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Cancer-associated isocitrate dehydrogenase (IDH) 1 and 2 mutations gain a new activity of reducing α-KG to produce D-2-hydroxyglutarate (D-2-HG), which is proposed to function as an oncometabolite by inhibiting α-KG dependent dioxygenases. We investigated the function of D-2-HG in tumorigenesis using IDH1 and IDH2 mutant cancer cell lines. Inhibition of D-2-HG production either by specific deletion of the mutant IDH1-R132C allele or overexpression of D-2-hydroxyglutarate dehydrogenase (D2HGDH) increases α-KG and related metabolites, restores the activity of some α-KG-dependent dioxygenases, and selectively alters gene expression. Ablation of D-2-HG production has no significant effect on cell proliferation and migration, but strongly inhibits anchorage independent growth in vitro and tumor growth in xenografted mouse models. Our study identifies a new activity of oncometabolite D-2-HG in promoting tumorigenesis.
Molecular identification of the tropical seagrass Halophila stipulacea from Turkey
Creators: name: VARELA-ÁLVAREZ, Elena
name: RINDI, Fabio
name: CAVAS, Levent
name: SERRÃO, Ester A.
name: DUARTE, Carlos M.
name: MARBÁ, Nuria
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2011

description: Halophila stipulacea (Forsskål) Ascherson, a tropical seagrass, is thought to be a Lessepsian immigrant that entered the Mediterranean Sea from the Red Sea after the opening of the Suez Canal (1869). Up to date, no genetic studies of H. stipulacea from Turkey are available. In order to verify the molecular identity of Turkish isolates of H. stipulacea, a part of the rDNA ITS region was sequenced. Comparisons of the genetic polymorphism of this region between isolates from the Turkish coasts of the Aegean Sea and individuals from putative native (Red Sea) and introduced (Mediterranean) populations deposited previously in GenBank were performed. No intra-individual variability was found in the region considered among the isolates from Turkey.
A new genus and two new species of Cavibelonia (Mollusca: Solenogastres) from the Abyssal Angola Basin
Creators: name: GIL-MANSILLA, Esther
name: GARCÍA-ÁLVAREZ, Oscar
name: URGORRI, Victoriano
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2011

description: During the expedition Me48/1 DIVA 1 in the Abyssal Angola Basin, a small collection of Solenogastres was collected. In this article, a new genus and two new species, Lophomenia dorsocaeca sp. nov. and Abyssoherpia ctenata gen et sp. nov., collected at depths of 5390-5415 m, which present some characters that complete the diagnoses of several supra- generic taxa, are described.
Monitoring the subtidal macroalgae percentage cover in an assessment of the human impact on diving sites in Brittany (France): direct estimation versus photography
Creators: name: CARPENTIER, Alexandre
name: ARTERO, Céline
name: OUISSE, Vincent
name: PERRIN, Bertrand
name: YSNEL, Frédéric
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2011

description: The fluctuation in macroalgae percentage cover was used as a bioindicator parameter to evaluate the potential impact of SCUBA divers around mooring buoys. The technical aim of the survey was to try out standardised, rapid and easily reproducible methods to assess measures for surveyors potentially unskilled in algal taxonomy, especially in subtidal areas. In this context, we put forward two methods to test macroalgae % cover estimation via, i) direct estimation from a drawing of sampling quadrats with a standardized drawing board and ii) computer treatment of digital pictures. In order to compare the two methods, six algal morphotypes were surveyed by three divers who were novice phycologists. No methodological effect or diver effect was found, indicating that error from direct estimation from drawings was negligible, and that our rapid, cost effective method was highly reproducible.
Supporting information from Linking dynamical complexities from activation signals to transcription responses
Creators: name: Genghong Lin
name: Jiao, Feng
name: Qiwen Sun
name: Moxun Tang
name: Jianshe Yu
name: Zhou, Zhan
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: 60114 Systems Biology
subject: FOS: Biological sciences
subject: Computational Biology
subject: 10202 Biological Mathematics
subject: FOS: Mathematics

description: This file includes the derivations of mathematical equations and complete proofs of Theorem 1 and Theorem 2.
(400869) Thomas Neave
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Feeding habits of the red scorpionfish, Scorpaena scrofa (Osteichthyes: Scorpaenidae) from the eastern central Adriatic Sea
Creators: name: ŠANTIĆ, Mate
name: PALLAORO, Armin
name: STAGLIČIĆ, Nika
name: MARKOV-PODVINSKI, Martina
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2011

description: The diet of the red scorpionfish, Scorpaena scrofa, from the central Adriatic Sea, was investigated with respect to fish size and seasons. Stomach contents of 684 specimens, 9.1 to 44.0 cm total length (TL), collected by trammel bot- tom nets from January 2006 to December 2008 were analysed. The prey species identified in the stomachs belonged to five major groups: Cephalopoda, Isopoda, Amphipoda, Decapoda (Natantia and Reptantia) and Teleostei. Teleosts were the most important ingested preys (IRI% = 80.4), especially in fish larger than 20 cm TL. Small preys like amphipods, isopods and natantia decapods constituted the main preys in the diet of fish smaller than 15 cm TL. Two teleosts, Chromis chromis and Spicara smaris were the most frequent preys. The mean weight of stomach contents increased significantly for fish larger than 25 cm TL, while the mean number of prey items did not differ significantly among length classes. Diet composition showed little seasonal variation; teleosts were the most important preys in all seasons especially during the winter. The percentage of empty stomachs showed seasonal variation, with maximal occurrence in winter (34.3%) and summer (21.5 %) and minimal in spring (6.9%). The lowest feeding frequency is probably related with lower sea temperature during the winter and with spawning period throughout the summer. The stomach contents of the red scorpionfish indicate that this species could be a generalist predator.
Disrupting LIN28 in atypical teratoid rhabdoid tumors reveals the importance of the mitogen activated protein kinase pathway as a therapeutic target
Creators: name: Maynard, Rachael
name: Mao, Xing gang
name: Orr, Brent A.
name: Weingart, Melanie F.
name: Busse, Tracy M.
name: Price, Antoinette
name: Kuwahara, Yasumichi
name: Rubens, Jeffrey
name: Kaur, Harpreet
name: Xu, Jingying
name: Eberhart, Charles G.
name: Roth, Jacquelyn J.
name: Erdreich-Epstein, Anat
name: Raabe, Eric H.
name: Biegel, Jaclyn A.
name: Taylor, Isabella
name: Weissman, Bernard E.
name: Hutt-Cabezas, Marianne
name: Allen, Sariah J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Atypical teratoid rhabdoid tumor (AT/RT) is among the most fatal of all pediatric brain tumors. Aside from loss of function mutations in the SMARCB1 (BAF47/INI1/SNF5) chromatin remodeling gene, little is known of other molecular drivers of AT/RT. LIN28A and LIN28B are stem cell factors that regulate thousands of RNAs and are expressed in aggressive cancers. We identified high-levels of LIN28A and LIN28B in AT/RT primary tumors and cell lines, with corresponding low levels of the LIN28-regulated microRNAs of the let-7 family. Knockdown of LIN28A by lentiviral shRNA in the AT/RT cell lines CHLA-06-ATRT and BT37 inhibited growth, cell proliferation and colony formation and induced apoptosis. Suppression of LIN28A in orthotopic xenograft models led to a more than doubling of median survival compared to empty vector controls (48 vs 115 days). LIN28A knockdown led to increased expression of let-7b and let-7g microRNAs and a down-regulation of KRAS mRNA. AT/RT primary tumors expressed increased mitogen activated protein (MAP) kinase pathway activity, and the MEK inhibitor selumetinib (AZD6244) decreased AT/RT growth and increased apoptosis. These data implicate LIN28/RAS/MAP kinase as key drivers of AT/RT tumorigenesis and indicate that targeting this pathway may be a therapeutic option in this aggressive pediatric malignancy.
Dynamic 1H-MRS assessment of brain tumors: A novel approach for differential diagnosis of glioma
Creators: name: Zhu, Jianming
name: Tong, Tong
name: Yao, Zhenwei
name: Chen, John W.
name: Yang, Zhong
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: PurposeTo determine whether the changes of [Cho/NAA] ratio in patients with glioma, measured by dynamic 1H-MRS can be used to differentiate between high-grade and low-grade gliomas.Materials and MethodsThis prospective study was approved by the institutional ethics committee. Written informed consent was obtained. Forty-nine patients with biopsy-proven glioma and 20 normal control subjects were recruited in this study. The maximum [Cho/NAA] ratios, acquired at 0 min, and at 6 min, were calculated and assessed from volume of interests (VOI) in the tumor areas and in the surrounding normal tissue for each patient. Absolute difference in the [Cho/NAA] ratios, from MRS acquired at 0 and 6 min, in high-grade glioma, low-grade glioma, and control subjects were compared.ResultsThe maximum [Cho/NAA] ratio acquired from the tumor area at the 0 min is 6.08 ± 2.02, which was significantly different (p = .017) from that acquired after 6 min, 4.87 ± 2.13. The [Cho/NAA] ratio from the surrounding normal tissue area did not change significantly from spectra acquired at different times (0 min, 6 min). Absolute difference in [Cho/NAA] ratios acquired at 0 and 6 min time points were significantly higher (P < 0.001) in high-grade glioma (= 3.86 ± 3.31) than in low-grade glioma (= 0.81 ± 0.90), and control subjects (0.061 ± 0.026, P = 0.000), while there was no significantly difference in low-grade glioma and control subjects.ConclusionsDynamic 1H-MRS can be useful for differential diagnosis between high-grade and low-grade gliomas as well as insight into the heterogeneity within the tumor.
(400868) David Chalmers Neave
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(400867) John Spink Neave
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Dysregulated CXCR4 expression promotes lymphoma cell survival and independently predicts disease progression in germinal center B-cell-like diffuse large B-cell lymphoma
Creators: name: Zu, Youli
name: Chiu, April
name: Pham, Lan
name: Hsi, Eric D.
name: Ponzoni, Maurilio
name: Young, Ken H.
name: Bhagat, Govind
name: Orazi, Attilio
name: Piris, Miguel A.
name: Møller, Michael B.
name: Han van Krieken, J.
name: Choi, William W.L.
name: Deng, Lijuan
name: Winter, Jane N.
name: Yin, Lihui
name: Dybkaer, Karen
name: Xu-Monette, Zijun Y.
name: Visco, Carlo
name: Tzankov, Alexandar
name: Montes-Moreno, Santiago
name: Ferreri, Andrés J.M.
name: Zhao, Xiaoying
name: Manyam, Ganiraju C.
name: Richards, Kristy L.
name: Huh, Jooryung
name: Chen, Jiayu
name: Farnen, John P.
name: Shen, Qi
name: Martinez-Lopez, Azahara
name: Zhang, Li
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Abnormal expression of the chemokine receptor CXCR4 plays an essential role in tumor cell dissemination and disease progression. However, the significance of CXCR4 overexpression in de novo diffuse large B cell lymphoma (DLBCL) is unknown. In 743 patients with de novo diffuse large B cell lymphoma (DLBCL) who received standard Rituximab-CHOP immunochemotherapy, we assessed the expression of CXCR4 and dissected its prognostic significance in various DLBCL subsets. Our results showed that CXCR4+ patients was associated with male, bulky tumor, high Ki-67 index, activated B-cell-like (ABC) subtype, and Myc, Bcl-2 or p53 overexpression. Moreover, CXCR4+ was an independent factor predicting poorer progression-free survival in germinal-center B-cell-like (GCB)-DLBCL, but not in ABC-DLBCL; and in patients with an IPI of ≤2, but not in those with an IPI>2. The lack of prognostic significance of CXCR4 in ABC-DLBCL was likely due to the activation of p53 tumor suppressor attenuating CXCR4 signaling. Furthermore, concurrent CXCR4+ and BCL2 translocation showed dismal outcomes resembling but independent of MYC/BCL2 double-hit DLBCL. Gene expression profiling suggested that alterations in the tumor microenvironment and immune responses, increased tumor proliferation and survival, and the dissemination of CXCR4+ tumor cells to distant organs or tissues were underlying molecular mechanisms responsible for the CXCR4+ associated poor prognosis.
Supporting Information from The evolution of life-history theory: a bibliometric analysis of an interdisciplinary research area.
Creators: name: Nettle, Daniel
name: Frankenhuis, Willem E.
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 60801 Animal Behaviour

description: Additional analyses and data
STEREOSELECTIVE SYNTHESIS OF A-AMINO ACIDS B-SUBSTITUTED WITH A 4,5-DIHYDROISOXAZOLE NUCLEUS AND OF TERTIARY AND QUATERNARY ALLYLSILANES
Creators: name: GALLANTI, MADDALENA
Publisher: name: Universit� degli Studi di Milano
Year: 2012

description: In the section A of the thesis is presented a stereoselective synthesis of b-hydroxy-a -amino acids b-substituted with a 4,5 dihydroisoxazole nucleus through an aldol type reaction between Schollkopf reagent and isoxazolynil aldehydes and ketones. In the section B is presented the preparation of allyl- or crotylsilane in high dr and er via the lithiation-borylation reaction of alkylcarbamates with silaboronates.The synthesis of quaternary allylsilane through a related strategy is also presented.
The dimension of knowledge on built environment interventions. The evolution of performance analysis models between theories and practice
Creators: name: Fianchini, Maria
Publisher: name: TECHNE - Journal of Technology for Architecture and Environment
Year: 2017

description: This paper deals with the building performance evaluation, as a methodological approach to the analysis of existing building systems, aimed at supporting the decision-making process for rehabilitation and / or adaptive reuse. It presents a critical review of national and international studies and enlightens the different conditions and ways of application, in the case of empty buildings compared to those in use. In conclusion, it introduces some limits of such methodologies with respect to appropriate knowledge objectives when applied to buildings with particular or magnificent characters, as well as some possible research lines to be explored so to overcome them.
description: TECHNE - Journal of Technology for Architecture and Environment, TECHNE 13 (2017): Theories Practice Design
(400866) Jean [Jane] Spink
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Temperature dependence of scintillation properties of SrMoO4
Creators: name: Mikhailik, V. B.
name: Elyashevskyi, Yu.
name: Kraus, H.
name: Kim, H. J.
name: Kapustianyk, V.
name: Panasyuk, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Studies of the X-ray luminescence and scintillation properties of a SrMoO4 crystal as function of temperature down to T=10 K have been carried out. The luminescence in SrMoO4 is quenched at room temperature, but below T<200 K the crystal exhibits a broad emission band with a maximum at a wavelength of 520 nm. The emission is attributed to the radiative decay of self-trapped excitons and defects acting as traps for the exactions at low temperatures. Such complex character of radiative decay is reflected in the kinetics which contains several components plus a contribution from delayed recombination at low temperatures. The temperature dependence of scintillation light output of SrMoO4 was studied. Comparing with a reference ZnWO4 crystal measured under the same experimental conditions it was found that the light output of SrMoO4 is 15+-5%. It is suggested, therefore, that there is scope for optimisation of strontium molybdate for application as scintillator in cryogenic rare event searches
Supporting Information from The evolution of life-history theory: a bibliometric analysis of an interdisciplinary research area
Creators: name: Nettle, Daniel
name: Frankenhuis, Willem E.
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 60801 Animal Behaviour

description: Additional analyses and data
Efficacy of a Mer and Flt3 tyrosine kinase small molecule inhibitor, UNC1666, in acute myeloid leukemia
Creators: name: Wang, Xiaodong
name: Hill, Amanda A.
name: Zhang, Dehui
name: Jordan, Craig T.
name: Shelton Earp, H.
name: Rinella, Sean
name: Stashko, Michael A.
name: Wei, Qi
name: Frye, Stephen
name: Page, Lauren S.
name: Zhang, Weihe
name: Kirkpatrick, Gregory
name: Lee-Sherick, Alisa B.
name: Liu, Jing
name: Menachof, Kelly K.
name: DeRyckere, Deborah
name: Graham, Douglas K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Mer and Flt3 receptor tyrosine kinases have been implicated as therapeutic targets in acute myeloid leukemia (AML). In this manuscript we describe UNC1666, a novel ATP-competitive small molecule tyrosine kinase inhibitor, which potently diminishes Mer and Flt3 phosphorylation in AML. Treatment with UNC1666 mediated biochemical and functional effects in AML cell lines expressing Mer or Flt3 internal tandem duplication (ITD), including decreased phosphorylation of Mer, Flt3 and downstream effectors Stat, Akt and Erk, induction of apoptosis in up to 98% of cells, and reduction of colony formation by greater than 90%, compared to treatment with vehicle. These effects were dose-dependent, with inhibition of downstream signaling and functional effects correlating with the degree of Mer or Flt3 kinase inhibition. Treatment of primary AML patient samples expressing Mer and/or Flt3-ITD with UNC1666 also inhibited Mer and Flt3 intracellular signaling, induced apoptosis, and inhibited colony formation. In summary, UNC1666 is a novel potent small molecule tyrosine kinase inhibitor that decreases oncogenic signaling and myeloblast survival, thereby validating dual Mer/Flt3 inhibition as an attractive treatment strategy for AML.
(400865) Thomas Chalmers Neave
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
eIF4E binding protein 1 expression is associated with clinical survival outcomes in colorectal cancer
Creators: name: Chao, Min Wu
name: Teng, Che Ming
name: Lai, Chin Yu
name: Lee, Kuo Hsiung
name: Cheng, Ya Wen
name: Wang, Li Ting
name: Yang, Xiao Ming
name: Pan, Shiow Lin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: eIF4E binding protein 1 (4E-BP1), is critical for cap-dependent and cap-independent translation. This study is the first to demonstrate that 4E-BP1 expression correlates with colorectal cancer (CRC) progression. Compared to its expression in normal colon epithelial cells, 4E-BP1 was upregulated in CRC cell lines and was detected in patient tumor tissues. Furthermore, high 4E-BP1 expression was statistically associated with poor prognosis. Hypoxia has been considered as an obstacle for cancer therapeutics. Our previous data showed that YXM110, a cryptopleurine derivative, exhibited anticancer activity via 4E-BP1 depletion. Here, we investigated whether YXM110 could inhibit protein synthesis under hypoxia. 4E-BP1 expression was notably decreased by YXM110 under hypoxic conditions, implying that cap-independent translation could be suppressed by YXM110. Moreover, YXM110 repressed hypoxia-inducible factor 1α (HIF-1α) expression, which resulted in decreased downstream vascular endothelial growth factor (VEGF) expression. These observations highlight 4E-BP1 as a useful biomarker and therapeutic target, indicating that YXM110 could be a potent CRC therapeutic drug.
First record of a rare carangid species, the Almaco Jack, Seriola rivoliana (Osteichthyes: Carangidae) in Tunisian marine waters (central Mediterranean)
Creators: name: MANSOUR, Sonia
name: AZZOUZ, Karima
name: BOUMAÏZA, Moncef
name: BEN AMOR, Mohamed Mourad
name: CAPAPÉ, Christian
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2011

description: Investigations conducted off the northern Tunisian coast (central Mediterranean) allow the authors to collect a juvenile female of the Almaco Jack, Seriola rivolianaValenciennes, 1833. The specimen is described in this note, including morphometric measurements and meristic counts. It is the first record of S. rivoliana in Tunisian marine waters and the third for the Mediterranean Sea.
Energy gaps in high-transition temperature cuprate superconductors
Creators: name: Hashimoto, Makoto
name: Vishik, Inna M.
name: He, Rui-Hua
name: Devereaux, Thomas P.
name: Shen, Zhi-Xun
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The spectral energy gap is an important signature that defines states of quantum matter: insulators, density waves, and superconductors have very different gap structures. The momentum resolved nature of angle-resolved photoemission spectroscopy (ARPES) makes it a powerful tool to characterize spectral gaps. ARPES has been instrumental in establishing the anisotropic d-wave structure of the superconducting gap in high-transition temperature (Tc) cuprates, which is different from the conventional isotropic s-wave superconducting gap. Shortly afterwards, ARPES demonstrated that an anomalous gap above Tc, often termed the pseudogap, follows a similar anisotropy. The nature of this poorly understood pseudogap and its relationship with superconductivity has since become the focal point of research in the field. To address this issue, the momentum, temperature, doping, and materials dependence of spectral gaps have been extensively examined with significantly improved instrumentation and carefully matched experiments in recent years. This article overviews the current understanding and unresolved issues of the basic phenomenology of gap hierarchy. We show how ARPES has been sensitive to phase transitions, has distinguished between orders having distinct broken electronic symmetries, and has uncovered rich momentum and temperature dependent fingerprints reflecting an intertwined & competing relationship between the ordered states and superconductivity that results in multiple phenomenologically-distinct ground states inside the superconducting dome. These results provide us with microscopic insights into the cuprate phase diagram.
description: A review article for ARPES studies on high-Tc cuprates. 6 figures
Age and growth pattern of the round sardinella Sardinella aurita Valenciennes, 1847 (Clupeidae) in the eastern central Adriatic Sea
Creators: name: MUSTAĆ, Bosiljka
name: SINOVČIĆ, Gorenka
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2011

description: A total of 2,033 round sardinella specimens were analysed from November 2007 to January 2009. A monthly random sampling of purse seine catches in the eastern central Adriatic Sea was used. The total length of males (N = 983) varied from 11.5 to 28.0 cm (mean ± SD = 21.8 ± 3.21 cm). It ranged from 11.0 to 32.5 cm (mean ± SD = 22.5 ± 3.67 cm) for females (N = 1021) and from 10.0 to 16.5 cm (mean ± SD = 12.6 ± 1.27 cm) for undetermined specimens (N = 29). A significant difference between the mean length of males and females was observed (t = 4.349, P < 0.001). Sex ratio was F/M = 1.04, with females slightly dominating over males. The age of round sardinella ranged from 0 to 5+ ages based on the otolith age reading method. The prevailing age in both sexes was 2+ and 3+ (79.44%). Growth parameters for all specimens were: L∞ = 34.21 cm, W∞ = 400.39 g, K = 0.362, t0 = -0.943. The length-weight relationship indicated a posi- tive allometric growth, TW=0.0036TL3.2266.
A Two-Step Linear Programming Model for Energy-Efficient Timetables in Metro Railway Networks
Creators: name: Gupta, Shuvomoy Das
name: Tobin, J. Kevin
name: Pavel, Lacra
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics

description: In this paper we propose a novel two-step linear optimization model to calculate energy-efficient timetables in metro railway networks. The resultant timetable minimizes the total energy consumed by all trains and maximizes the utilization of regenerative energy produced by braking trains, subject to the constraints in the railway network. In contrast to other existing models, which are NP-hard, our model is computationally the most tractable one being a linear program. We apply our optimization model to different instances of service PES2-SFM2 of line 8 of Shanghai Metro network spanning a full service period of one day (18 hours) with thousands of active trains. For every instance, our model finds an optimal timetable very quickly (largest runtime being less than 13s) with significant reduction in effective energy consumption (the worst case being 19.27%). Code based on the model has been integrated with Thales Timetable Compiler - the industrial timetable compiler of Thales Inc that has the largest installed base of communication-based train control systems worldwide.
description: 25 pages, 7 figures
Erratum: Clinical and biological significance of de novo CD5+ diffuse large B-cell lymphoma in Western countries
Creators: name: Medeiros, L. Jeffrey
name: Zu, Youli
name: Winter, Jane N.
name: Tzankov, Alexandar
name: Tu, Meifeng
name: Nagarajan, Lalitha
name: Orazi, Attilio
name: Farnen, John P.
name: Ferreri, Andrés J.M.
name: Dybkaer, Karen
name: Choi, William W.L.
name: Zhao, Xiaoying
name: Jabbar, Kausar J.
name: van Krieken, J. Han
name: Ponzoni, Maurilio
name: Montes-Moreno, Santiago
name: Huh, Jooryung
name: Piris, Miguel A.
name: An, Yuji
name: Visco, Carlo
name: Xu-Monette, Zijun Y.
name: Cao, Xin
name: Young, Ken H.
name: Chiu, April
name: Miranda, Roberto N.
name: Hsi, Eric D.
name: Cai, Qinging
name: Møller, Michael B.
name: Bhagat, Govind
name: Richards, Kristy L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: CD5 is a pan-T-cell surface marker and is rarely expressed in diffuse large B-cell lymphoma (DLBCL). Large-scale studies of de novo CD5+ DLBCL are lacking in Western countries. In this study by the DLBCL Rituximab-CHOP Consortium, CD5 was expressed in 5.5% of 879 DLBCL patients from Western countries. CD5+ DLBCL was associated with higher frequencies of >1 ECOG performance status, bone marrow involvement, central nervous system relapse, activated B-cell–like subtype, Bcl-2 overexpression, and STAT3 and NF-κB activation, whereas rarely expressed single-stranded DNA-binding protein 2 (SSBP2), CD30 or had MYC mutations. With standard R-CHOP chemotherapy, CD5+ DLBCL patients had significantly worse overall survival (median, 25.3 months vs. not reached, P< .0001) and progression-free survival (median, 21.3 vs. 85.8 months, P< .0001) than CD5− DLBCL patients, which was independent of Bcl-2, STAT3, NF-κB and the International Prognostic Index. Interestingly, SSBP2 expression abolished the prognostic significance of CD5 expression, suggesting a tumor-suppressor role of SSBP2 for CD5 signaling. Gene-expression profiling demonstrated that B-cell receptor signaling dysfunction and microenvironment alterations are the important mechanisms underlying the clinical impact of CD5 expression. This study shows the distinctive clinical and biological features of CD5+ DLBCL patients in Western countries and underscores important pathways with therapeutic implications.
Expression profile of innate immune receptors, NLRs and AIM2, in human colorectal cancer: correlation with cancer stages and inflammasome components
Creators: name: Song, Chaojun
name: Liu, Rongrong
name: Chen, Lihua
name: Truax, Agnieszka D.
name: Ting, Jenny Pan Yun
name: Chen, Jun
name: Li, Zengshan
name: Chen, Liang
name: Hu, Peizhen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: NLRs (nucleotide-binding domain leucine-rich repeat proteins or NOD-like receptors) are regulators of inflammation and immunity. A subgroup of NLRs and the innate immune receptor, AIM2 (absent-in-melanoma 2), can induce the assembly of a large caspase-1 activating complex called the inflammasome. Other NLRs regulate key signaling pathways such as NF-kB and MAPK. Since inflammation is a central component of colorectal cancer (CRC), this work was undertaken to analyze NLR and AIM2 expression in human CRC by combining bioinformatics analysis and experimental verification using clinical tissue samples. Additional experiments analyzed the association of (i) gene expression and cancer staging, and (ii) gene expression among inflammasome components.
Factors associated with COVID-19 vaccine uptake in people with kidney disease: an OpenSAFELY cohort study
Creators: name: Collaborative, The OpenSAFELY
name: Parker, Edward PK
name: Tazare, John
name: Hulme, William J
name: Bates, Christopher
name: Carr, Edward J
name: Cockburn, Jonathan
name: Curtis, Helen J
name: Fisher, Louis
name: Green, Amelia CA
name: Harper, Sam
name: Hester, Frank
name: Horne, Elsie MF
name: Loud, Fiona
name: Lyon, Susan
name: Mahalingasivam, Viyaasan
name: Mehrkar, Amir
name: Nab, Linda
name: Parry, John
name: Santhakumaran, Shalini
name: Steenkamp, Retha
name: Sterne, Jonathan AC
name: Walker, Alex J
name: Williamson, Elizabeth J
name: Willicombe, Michelle
name: Zheng, Bang
name: Goldacre, Ben
name: Nitsch, Dorothea
name: Tomlinson, Laurie A
Publisher: name: The Francis Crick Institute
Year: 2023
Subjects: subject: Infectious Disease
subject: Immunology
subject: FOS: Clinical medicine
subject: Cell Biology

description: Objective To characterise factors associated with COVID-19 vaccine uptake among people with kidney disease in England. Design Retrospective cohort study using the OpenSAFELY-TPP platform, performed with the approval of NHS England. Setting Individual-level routine clinical data from 24 million people across GPs in England using TPP software. Primary care data were linked directly with COVID-19 vaccine records up to 31 August 2022 and with renal replacement therapy (RRT) status via the UK Renal Registry (UKRR). Participants A cohort of adults with stage 3–5 chronic kidney disease (CKD) or receiving RRT at the start of the COVID-19 vaccine roll-out was identified based on evidence of reduced estimated glomerular filtration rate (eGFR) or inclusion in the UKRR. Main outcome measures Dose-specific vaccine coverage over time was determined from 1 December 2020 to 31 August 2022. Individual-level factors associated with receipt of a 3-dose or 4-dose vaccine series were explored via Cox proportional hazards models. Results 992 205 people with stage 3–5 CKD or receiving RRT were included. Cumulative vaccine coverage as of 31 August 2022 was 97.5%, 97.0% and 93.9% for doses 1, 2 and 3, respectively, and 81.9% for dose 4 among individuals with one or more indications for eligibility. Delayed 3-dose vaccine uptake was associated with younger age, minority ethnicity, social deprivation and severe mental illness—associations that were consistent across CKD severity subgroups, dialysis patients and kidney transplant recipients. Similar associations were observed for 4-dose uptake. Conclusion Although high primary vaccine and booster dose coverage has been achieved among people with kidney disease in England, key disparities in vaccine uptake remain across clinical and demographic groups and 4-dose coverage is suboptimal. Targeted interventions are needed to identify barriers to vaccine uptake among under-vaccinated subgroups identified in the present study.
Supplementary Information from Nocturnal flight-calling behaviour predicts vulnerability to artificial light in migratory birds.
Creators: name: Winger, Benjamin M.
name: Weeks, Brian C.
name: Farnsworth, Andrew
name: Jones, Andrew W.
name: Hennen, Mary
name: Willard, David E.
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 60801 Animal Behaviour

description: Supplementary explanation of methodology; supplementary results (Tables S1-S3, Figures S1-S8)
First study in the Mediterranean of gametogenesis of the Oyster Ostrea stentina (Payraudeau, 1826) in the gulf of Hammamet
Creators: name: EL GHARSALLI, Refka
name: ALOUI-BEJAOUI, Nejla
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2011

description: The gametogenic cycle of the dwarf oyster Ostrea stentina has not been studied so far so that there was a lack of information about its reproduction in Tunisia and in the Mediterranean region. The abundance of Ostreidae in the port of Yasmine Hammamet made it possible to monitor the gonadal development for a 1-year period from September 2005 to August 2006; quantitative and qualitative histology made it possible to characterize the sexual cycle of the species and to see if there was a correlation between the temperature of the water and gametogenic activity. The oyster O. stentina showed a successive hermaphroditism with a consecutive rhythmic sexuality on the basis of histological observation. Reproduction occurs continuously throughout the year with two reproductive cycles for each sex. This species showed an asynchronism between the sexes both in terms of the spawning period during the first female and male gametogenic cycle, except in April. The second cycle begins immediately after the spawning period. The spawned males during the July-November period and the spawned females during the July–December period for the second cycle indicate that July to November can be considered the best time for fertilization. No resting period was observed between the first and the second gametogenic cycle. The mature stage occurred at a sea surface temperature above 20°C and the spawning stage when the temperature rose to approx. 28°C. An analysis of the oocytes' diametres was made according to the stages of oogenesis and the minimum diametres coincided with the developing stage, and the maximum diametres coincided with the mature and spawned stage.
Recent Brachiopoda of the Marine Protected Area "Secche di Tor Paterno", Central Tyrrhenian Sea
Creators: name: EVANGELISTI, Francesca
name: ALBANO, Paolo G.
name: SABELLI, Bruno
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2011

description: The Brachiopoda of the infralittoral substrates of the Marine Protected Area "Secche di Tor Paterno", Central Tyrrhenian Sea, are described and illustrated. Four species are reported: Novocrania anomala, Megathiris detruncata, Argyrotheca cuneata and Joania cordata. The diversity is lower than the potential infralittoral Mediterranean brachiopod fauna, but further explorations of the reefs may increase the number of species. Most specimens were found as empty shells in the sediments. A. cuneata and J. cordata are the most abundant species (96.6% of the total examined material) thus indicating that the reef is a suitable environment for both species. A few live specimens of both species were found in the coralligenous and in the Posidonia rhizomes (only J. cordata). The occurrence of brachiopods in the Posidonia rhizomes is poorly documented in literature. Moreover, in this habitat, one specimen of J. cordata was found attached to a live Muricopsis aradasii (Gastropoda, Muricidae), thus representing an interesting case of phoresis.
Supplementary Information from Nocturnal flight-calling behaviour predicts vulnerability to artificial light in migratory birds
Creators: name: Winger, Benjamin M.
name: Weeks, Brian C.
name: Farnsworth, Andrew
name: Jones, Andrew W.
name: Hennen, Mary
name: Willard, David E.
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 60801 Animal Behaviour

description: Supplementary explanation of methodology; supplementary results (Tables S1-S3, Figures S1-S8)
Histone modifications change with age, dietary restriction and rapamycin treatment in mouse brain
Creators: name: Qian, Hong
name: Ertl, Robin
name: Wang, Gang G.
name: Astle, Clinton M.
name: Xu, Xiangru
name: Harrison, David E.
name: Gong, Huan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The risk of developing neurodegenerative disorders such as Alzheimer's disease (AD) increases dramatically with age. Understanding the underlying mechanisms of brain aging is crucial for developing preventative and/or therapeutic approaches for age-associated neurological diseases. Recently, it has been suggested that epigenetic factors, such as histone modifications, maybe be involved in brain aging and age-related neurodegenerations. In this study, we investigated 14 histone modifications in brains of a cohort of young (3 months), old (22 months), and old age-matched dietary restricted (DR) and rapamycin treated BALB/c mice. Results showed that 7 out of all measured histone markers were changed drastically with age. Intriguingly, histone methylations in brain tissues, including H3K27me3, H3R2me2, H3K79me3 and H4K20me2 tend to disappear with age but can be partially restored by both DR and rapamycin treatment. However, both DR and rapamycin treatment also have a significant impact on several other histone modifications such as H3K27ac, H4K16ac, H4R3me2, and H3K56ac, which do not change as animal ages. This study provides the first evidence that a broad spectrum of histone modifications may be involved in brain aging. Besides, this study suggests that both DR and rapamycin may slow aging process in mouse brain via these underlying epigenetic mechanisms.
$a_{0}(980)$ revisited
Creators: name: Wolkanowski, Thomas
name: Giacosa, Francesco
name: Rischke, Dirk H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Light scalar hadrons can be understood as dynamically generated resonances. These arise as `companion poles' in the propagators of quark-antiquark seed states when accounting for meson-loop contributions to the self-energies of the latter. Along this line, we extend previous calculations of Törnqvist and Roos and of Boglione and Pennington, where the resonance $a_{0}(980)$ appears as companion pole in the propagator of $a_{0}(1450)$ which is predominantly a quark-antiquark state. We also construct an effective Lagrangian where $a_{0}(1450)$ couples to pseudoscalar mesons with both non-derivative and derivative interactions. Computing the one-loop self-energy, we demonstrate that the propagator has two poles: a companion pole corresponding to $a_{0}(980)$ and a pole of the seed state $a_{0}(1450)$. The positions of these poles are in quantitative agreement with experimental data.
description: 14 pages, 2 figures, 1 table
title: Zur Kenntnis der Azulene, IX. Azulen-π-Komplexe
Creators: name: Hafner, Klaus
name: Moritz, Karl-Ludwig
Publisher: name: Wiley-VCH
Year: 2023

description: Es werden Darstellung und Eigenschaften einiger kristallisierter Azulen-Tetracyanäthylen-Komplexe und deren Umwandlung in 1- bzw. 3-Tricyanvinyl-azulene beschrieben.
(400864) James Myles
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.