cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: ADCO, Sixième cartulaire de Saint-Étienne de Dijon (1662), Cart. 30 (G 133), 441 folios, f. 796
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Sixième cartulaire de Saint-Étienne de Dijon (1662), Archives départementales de la Côte-d'Or, Cart. 30 (G 133), 441 folios, f. 796, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Sixième cartulaire de Saint-Étienne de Dijon (1662), Archives départementales de la Côte-d'Or, Cart. 30 (G 133), 441 folios, f. 796, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
The Inverse Grating Problem: Efficient Design of Anomalous Flexural Wave Reflectors and Refractors
Creators: name: Packo, Pawel
name: Norris, Andrew N.
name: Torrent, Daniel
Publisher: name: arXiv
Year: 2018
Subjects: subject: Applied Physics (physics.app-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We present an extensive formulation of the inverse grating problem for exural waves, in which the energy of each diffracted mode is selected and the grating configuration is then obtained by solving a linear system of equations. The grating is designed as a lineal periodic repetition of a unit cell comprising a cluster of resonators attached at points whose physical properties are directly derived by inversion of a given matrix. Although both active and passive attachments can be required in the most general case, it is possible to find configurations with only passive, i.e. damped, solutions. This inverse design approach presents an alternative to the design of metasurfaces for exural waves overcoming the limitations of gradient phase metasurfaces, which require a continuous variation of the surface's impedance. When the grating is designed in such a way that all the energy is channeled to a single diffracted mode, it behaves as an anomalous refractor or re ector. The negative refractor is analyzed in depth, and it is shown that with only three scatterers per unit cell is it possible to build such a device with unitary efficiency.
Positron-neutrino correlations in 32Ar and 33Ar Decays: Probes of Scalar weak currents and nuclear isospin mixing
Creators: name: Garcia, A.
name: Adelberger, E. G.
name: Ortiz, C.
name: Swanson, H. E.
name: Beck, M.
name: Tengblad, O.
name: Borge, M. J. G.
name: Martel, I.
name: Bichsel, H.
name: Collaboration, the Isolde
Publisher: name: arXiv
Year: 1999
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The positron-neutrino correlation in the 0^+ \to 0^+ βdecay of ^{32}Ar was measured at ISOLDE by analyzing the effect of lepton recoil on the shape of the narrow proton group following the superallowed decay. Our result is consistent with the Standard Model prediction; for vanishing Fierz interference we find a=0.9989 \pm 0.0052 \pm 0.0036. Our result leads to improved constraints on scalar weak interactions. The positron-neutrino correlation in ^{33}Ar decay was measured in the same experiment; for vanishing Fierz interference we find a=0.944 \pm 0.002 \pm 0.003. The ^{32}Ar and ^{33}Ar correlations, in combination with precision measurements of the half-lives, superallowed branching ratios and beta endpoint energies, will determine the isospin impurities of the superallowed transitions. These will provide useful tests of isospin-violation corrections used in deducing |V_{\rm ud}| which currently indicates non-unitarity of the KM matrix.
description: 15 pages, 6 figures
Curculio hispidus Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Curculio
Curculio hispidus

description: Curculio hispidus [spec. nov.]
C. longirostris, femoribus dentatis, corpore sulcato adsperso squamis erectis.
Habitat in Europa.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 383, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Capsulactone: a new 4-hydroxy-α-pyrone derivative from an endophytic fungus Penicillium capsulatum and its antimicrobial activity
Creators: name: Xian, Peng-Jie
name: Chen, Heng-Ye
name: Feng, Zhang
name: Zhao, Wei
name: Yang, Xiao-Long
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences

description: A new 4-hydroxy-α-pyrone, namely capsulactone (1), was isolated from an endophytic fungus Penicillium capsulatum XL027 obtained from the leaves of Panax notoginseng. The structure and absolute configuration of 1 were elucidated through a combination of spectroscopic data and computed methods, as well as by comparison with literature data. Compound 1 exhibited weak activity against methicinllin-resistant Staphylococcus aureus with an MIC value of 100 μg/ml.
Some multidimensional integrals in number theory and connections with the Painlevé V equation
Creators: name: Basor, Estelle
name: Ge, Fan
name: Rubinstein, Michael O.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: We study piecewise polynomial functions $γ_k(c)$ that appear in the asymptotics of averages of the divisor sum in short intervals. Specifically, we express these polynomials as the inverse Fourier transform of a Hankel determinant that satisfies a Painlevé V equation. We prove that $γ_k(c)$ is very smooth at its transition points, and also determine the asymptotics of $γ_k(c)$ in a large neighbourhood of $k=c/2$. Finally, we consider the coefficients that appear in the asymptotics of elliptic Aliquot cycles.
Development of Novel Low Biofouling Membranes for Use in Water Filtration Applications
Creators: name: Najjar, Ahmad
Publisher: name: Manara - Qatar Research Repository
Year: 2025
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences

description: Water scarcity is fast becoming a pressing issue around the world, in particular Qatar which is particularly vulnerable to future water shortages due to low precipitation levels and a rapidly booming human population. The reliance on desalination and ground water extraction pose challenges and may prove unsustainable in the future. In order to circumvent this issue, Qatar has set out a government mandate as part of its 2030 Vision to reuse at least 50% of all treated sewage effluent (TSE) it produces. In this work, locally obtained TSE had its bacterial community identified and alignment results indicated the presence of several pathogenic bacterial species, which brought the safety of using TSE in urbanized areas into question. Owing to the fact that the TSE produced in Qatar is treated to tertiary level at best, the need for advanced treatment to further polish the produced TSE has recently gained traction. Membrane filtration systems offer one such option; however, since membranes are heavily prone to biofouling processes, the need for low biofouling membranes remains a priority. To that end, a selection of low biofouling polymeric membranes were fabricated. Polysulfone (PS) membranes incorporating arabic gum (AG), polyethersulfone (PES) membranes incorporating in-house synthesized graphene oxide (GO) with AG and PES membranes with oxidized multiwalled carbon nanotubes (OMWCNT) with AG were extensively characterized by means of chemical and physical testing. The composite membranes showed superior surface hydrophilicity and increased surface charge with smoother surfaces compared to their respective neat membranes. These hallmark features of low biofouling membranes were implicated in conferring resistance to bacterial colonization. The novel composite membranes filtered bacterial suspensions and real TSE over prolonged periods without experiencing a notable decline in flux and were effective in the complete removal of bacteria from the permeates produced. These novel low biofouling membranes provide a promising solution to the "Achilles heel" of membrane technology, where their application in water filtration processes can be realized.
Optical transmission of an atomic vapor in the mesoscopic regime
Creators: name: Peyrot, T.
name: Sortais, Y. R. P.
name: Greffet, J. -J.
name: Browaeys, A.
name: Sargsyan, A.
name: Keaveney, J.
name: Hughes, I. G.
name: Adams, C. S.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: By measuring the transmission of near-resonant light through an atomic vapor confined in a nano-cell we demonstrate a mesoscopic optical response arising from the non-locality induced by the motion of atoms with a phase coherence length larger than the cell thickness. Whereas conventional dispersion theory -- where the local atomic response is simply convolved by the Maxwell-Boltzmann velocity distribution -- is unable to reproduce the measured spectra, a model including a non-local, size-dependent susceptibility is found to be in excellent agreement with the measurements. This result improves our understanding of light-matter interaction in the mesoscopic regime and has implications for applications where mesoscopic effects may degrade or enhance the performance of miniaturized atomic sensors.
description: 5 pages, 3 figures; Supplemental material : 9 pages, 4 figures
Curculio rectirostris Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Curculio
Curculio rectirostris

description: Curculio rectirostris [spec. nov.]
C. longirostris, femoribus dentatis, rostro rubro, elytris obsolete fasciatis.
Habitat in Europa.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 383, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Associations between chronic hepatitis B infection and inflammatory bowel diseases in East Asian populations
Creators: name: Ye, Haiyan
name: Wei, Deqin
name: Huang, Yike
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy

description: This study aims to investigate the effect of chronic hepatitis B (CHB) infection on inflammatory bowel disease (IBD) in East Asian populations. This study utilized summary statistics from genome-wide association studies (GWAS) on CHB infection, IBD, and its subtypes, including ulcerative colitis (UC) and Crohn’s disease (CD), in East Asian populations. A two-sample bidirectional Mendelian randomization (MR) analysis was conducted using various methods, including MR-Egger, weighted median, inverse-variance weighted (IVW), simple mode, and weighted mode. Sensitivity analyses were also performed to evaluate the robustness of the results. Forward MR analysis indicated that genetic susceptibility to CHB is a risk factor for total IBD (OR = 1.66, 95% CI = 1.48–1.87, p < 0.001) and its subtype CD (OR = 2.25, 95% CI = 1.84–2.74, p < 0.001) after Bonferroni correction. Genetic susceptibility to total IBD, UC or CD were not associated with CHB in the reverse MR analysis. Sensitivity analyses confirmed the robustness of the bidirectional MR results. This study suggests that genetic susceptibility to CHB infection is significantly associated with total IBD, particularly CD, in East Asian populations. This highlights the need for further investigation into the pathogenic mechanisms underlying this association.
Localization of eigenvector centrality in networks with a cut vertex
Creators: name: Sharkey, Kieran J.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Spectral Theory (math.SP)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We show that eigenvector centrality exhibits localization phenomena on networks that can be easily partitioned by the removal of a vertex cut set, the most extreme example being networks with a cut vertex. Three distinct types of localization are identified in these structures. One is related to the well-established hub node localization phenomenon and the other two are introduced and characterized here. We gain insights into these problems by deriving the relationship between eigenvector centrality and Katz centrality. This leads to an interpretation of the principal eigenvector as an approximation to more robust centrality measures which exist in the full span of an eigenbasis of the adjacency matrix.
Graves’ orbitopathy occurs sex-independently in an autoimmune hyperthyroid mouse model
Creators: name: Schlüter, Anke
name: Flögel, Ulrich
name: Diaz-Cano, Salvador J.
name: Gina-Eva Görtz
name: Stähr, Kerstin
name: Oeverhaus, Michael
name: Plöhn, Svenja
name: Mattheis, Stefan
name: Moeller, Lars C.
name: Lang, Stephan
name: Bechrakis, Nikolaos E.
name: J. Paul Banga
name: Eckstein, Anja
name: Berchner-Pfannschmidt, Utta
Publisher: name: figshare
Year: 2018
Subjects: subject: 110703 Autoimmunity
subject: FOS: Clinical medicine
subject: 110704 Cellular Immunology
subject: 110306 Endocrinology
subject: 110799 Immunology not elsewhere classified
subject: 110707 Innate Immunity
subject: 111301 Ophthalmology
subject: Pathogenesis
subject: 110316 Pathology (excl. Oral Pathology)
subject: 110320 Radiology and Organ Imaging

description: Graves’ orbitopathy (GO) is the most common extrathyroidal complication of Graves’ disease (GD) and occurs predominantly in women but more severe in men. The reason for this effect of gender on GO is unknown. Herein we studied the manifestation of GO in both sexes of an induced mouse model in the absence of additional risk factors present in patients like advanced age, genetic variabilities or smoking. Male and female mice were immunized with human TSHR A-subunit encoding plasmid. Both sexes comparably developed autoimmune hyperthyroidism characterized by TSHR stimulating autoantibodies, elevated T4 values, hyperplastic thyroids, and hearts. Autoimmune mice developed inflammatory eye symptoms and proptosis, although males earlier than females. Serial in vivo 1H/19F-magnetic resonance imaging revealed elevated inflammatory infiltration, increased fat volume and glycosaminoglycan deposition in orbits of both sexes but most significantly in female mice. Histologically, infiltration of T-cells, the extension of brown fat and overall collagen deposition were characteristics of GO in male mice. In contrast, female mice developed predominately macrophage infiltration in muscle and connective tissue and muscle hypertrophy. Apart from sex-dependent variabilities in pathogenesis, disease classification revealed minor sex- differences in incidence and total outcome. In conclusion, sex did not predispose to autoimmune hyperthyroidism and associated GO.
Self-organizing maps as a method for detecting phase transitions and phase identification
Creators: name: Shirinyan, Albert A.
name: Kozin, Valerii K.
name: Hellsvik, Johan
name: Pereiro, Manuel
name: Eriksson, Olle
name: Yudin, Dmitry
Publisher: name: arXiv
Year: 2018
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Originating from image recognition, methods of machine learning allow for effective feature extraction and dimensionality reduction in multidimensional datasets, thereby providing an extraordinary tool to deal with classical and quantum models in many-body physics. In this study, we employ a specific unsupervised machine learning technique -- self-organizing maps -- to create a low-dimensional representation of microscopic states, relevant for macroscopic phase identification and detecting phase transitions. We explore the properties of spin Hamiltonians of two archetype model system: a two-dimensional Heisenberg ferromagnet and a three-dimensional crystal, Fe in the body centered cubic structure. The method of self-organizing maps, that is known to conserve connectivity of the initial dataset, is compared to the cumulant method theory and is shown to be as accurate while being computationally more efficient in determining a phase transition temperature. We argue that the method proposed here can be applied to explore a broad class of second-order phase transition systems, not only magnetic systems but also, for example, order-disorder transitions in alloys.
description: 5 pages, 2 figures, Supplemental Material
Spironolactone as an adjuvant treatment for COVID-19: a systematic review and meta-analysis
Creators: name: Shafiee, Arman
name: Amini, Mohammad Javad
name: Rafiei, Mohammad Ali
name: Akhondi, Amirhossein
name: Jafarabady, Kyana
name: Molaverdi, Ghazale
name: Mozhgani, Sayed-Hamidreza
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: A systematic review and meta-analysis have been conducted to evaluate the efficacy of spironolactone as an adjuvant treatment for COVID-19 patients based on current evidence. We searched MEDLINE (PubMed), medRvix, Web of Science, Cochrane Library, Google Scholar, Clinicaltrials.gov, Collabovid, Research Square, ScienceDirect, and Oxford University Press for studies evaluating the efficacy of spironolactone as an adjuvant therapy for COVID-19 patients up to 30 April 2023. Based on the PRISMA 2020 statement criteria a systematic review and meta-analysis of studies were performed. The results of our meta-analysis showed a significant reduction in primary composite outcome (combined rate of mortality or severe disease occurrence) (OR = 0.28, 95% CI: 0.18 to 0.44), mortality (OR = 0.24, 95% CI: 0.12 to 0.47), and progression to severe disease (OR = 0.44, 95% CI: 0.26 to 0.75) in the spironolactone group compared to controls. Spironolactone therapy did not significantly improve the time to recovery (MD = -1.09, 95% CI: −2.63 to 1.46; I2 = 98%). Spironolactone can be an efficient and safe adjuvant treatment for COVID-19 patients alongside concomitant medications. Future randomized controlled trials are needed to strengthen the available evidence. What is this study about? This study looks at whether spironolactone, a commonly used medication, can help people with COVID-19 when added to their usual treatments. Spironolactone has properties that may reduce inflammation and prevent severe illness. What did we do? We reviewed and analyzed studies from various research databases to see how effective spironolactone is for treating COVID-19. The studies included information about spironolactone’s ability to reduce death rates, prevent severe illness, and improve recovery time. What did we find? The results showed that spironolactone significantly reduced the risk of death and the chances of developing severe COVID-19. Patients who received spironolactone were 72% less likely to experience death or severe illness compared to those who didn’t. However, spironolactone did not significantly speed up recovery times. Why is this important? This research suggests that spironolactone may be a safe and effective additional treatment for COVID-19, especially in preventing severe cases. However, more studies are needed to confirm these findings and to better understand its role in treatment.
Development of a Gd Loaded Liquid Scintillator for Electron Anti-Neutrino Spectroscopy
Creators: name: Piepke, Andreas G.
name: Moser, S. Wayne
name: Novikov, Vladimir M.
Publisher: name: arXiv
Year: 1999
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We report on the development and deployment of 11.3 tons of 0.1% Gd loaded liquid scintillator used in the Palo Verde reactor neutrino oscillation experiment. We discuss the chemical composition, properties, and stability of the scintillator elaborating on the details of the scintillator preparation crucial for obtaining a good scintillator quality and stability.
description: 9 pages, 4 figures, submitted to NIM A
Excavations on the Site of St. Mildred's Church, Bread Street, London, 1973-74
Creators: name: P Marsden, Peter
name: T Dyson, Tony
name: M Rhodes, Michael
name: J Hammerson, Michael
Publisher: name: Archaeology Data Service
Year: 2021

description: Transactions of the London and Middlesex Archaeological Society, 2.26, 171-208
Associations between of chronic hepatitis B infection and inflammatory bowel diseases in East Asian populations
Creators: name: Ye, Haiyan
name: Wei, Deqin
name: Huang, Yike
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy

description: This study aims to investigate the effect of chronic hepatitis B (CHB) infection on inflammatory bowel disease (IBD) in East Asian populations. This study utilized summary statistics from genome-wide association studies (GWAS) on CHB infection, IBD, and its subtypes, including ulcerative colitis (UC) and Crohn’s disease (CD), in East Asian populations. A two-sample bidirectional Mendelian randomization (MR) analysis was conducted using various methods, including MR-Egger, weighted median, inverse-variance weighted (IVW), simple mode, and weighted mode. Sensitivity analyses were also performed to evaluate the robustness of the results. Forward MR analysis indicated that genetic susceptibility to CHB is a risk factor for total IBD (OR = 1.66, 95% CI = 1.48–1.87, p < 0.001) and its subtype CD (OR = 2.25, 95% CI = 1.84–2.74, p < 0.001) after Bonferroni correction. Genetic susceptibility to total IBD, UC or CD were not associated with CHB in the reverse MR analysis. Sensitivity analyses confirmed the robustness of the bidirectional MR results. This study suggests that genetic susceptibility to CHB infection is significantly associated with total IBD, particularly CD, in East Asian populations. This highlights the need for further investigation into the pathogenic mechanisms underlying this association.
High-accuracy mass, spin, and recoil predictions of generic black-hole merger remnants
Creators: name: Varma, Vijay
name: Gerosa, Davide
name: Stein, Leo C.
name: Hébert, François
name: Zhang, Hao
Publisher: name: arXiv
Year: 2018
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present accurate fits for the remnant properties of generically precessing binary black holes, trained on large banks of numerical-relativity simulations. We use Gaussian process regression to interpolate the remnant mass, spin, and recoil velocity in the 7-dimensional parameter space of precessing black-hole binaries with mass ratios $q\leq2$, and spin magnitudes $χ_1,χ_2\leq0.8$. For precessing systems, our errors in estimating the remnant mass, spin magnitude, and kick magnitude are lower than those of existing fitting formulae by at least an order of magnitude (improvement is also reported in the extrapolated region at high mass ratios and spins). In addition, we also model the remnant spin and kick directions. Being trained directly on precessing simulations, our fits are free from ambiguities regarding the initial frequency at which precessing quantities are defined. We also construct a model for remnant properties of aligned-spin systems with mass ratios $q\leq8$, and spin magnitudes $χ_1,χ_2\leq0.8$. As a byproduct, we also provide error estimates for all fitted quantities, which can be consistently incorporated into current and future gravitational-wave parameter-estimation analyses. Our model(s) are made publicly available through a fast and easy-to-use Python module called surfinBH.
description: 6+5 pages. Matches PRL version. Python implementation available at https://pypi.org/project/surfinBH/
Gut Microbiome in BALB/c and C57BL/6J Mice Undergoing Experimental Thyroid Autoimmunity Associate with Differences in Immunological Responses and Thyroid Function
Creators: name: Sajad Moshkelgosha
name: Masetti, Giulia
name: Berchner-Pfannschmidt, Utta
name: Verhasselt, Hedda Luise
name: Horstmann, Mareike
name: Diaz-Cano, Salvador J.
name: Noble, Alistair
name: Edelman, Barbel
name: Covelli, Danila
name: Plummer, Sue
name: Marchesi, Julian R.
name: Ludgate, Marian
name: Biscarini, Filippo
name: Eckstein, Anja
name: J. Paul Banga
Publisher: name: figshare
Year: 2018
Subjects: subject: 110703 Autoimmunity
subject: FOS: Clinical medicine
subject: 110303 Clinical Microbiology
subject: 110306 Endocrinology
subject: 110799 Immunology not elsewhere classified
subject: 110707 Innate Immunity
subject: 110316 Pathology (excl. Oral Pathology)

description: Experimental models of hyperthyroid Graves’ disease (GD) and Graves’ orbitopathy (GO) are efficiently developed by genetic immunisation by electroporation with human thyrotropin hormone receptor (hTSHR) A-subunit plasmid in female BALB/c (H-2d) mice. We investigated susceptibility in C57BL/6 J (H-2b) animals to allow studies on disease mechanisms in transgenic and immune response gene knock-out mice. Higher numbers of female C57BL/6 J were positive for pathogenic thyroid stimulating antibodies, but induced hyperthyroidism remained at a low frequency compared to BALB/c animals. Assessment of hTSHR specific T cells showed reduced proliferation in C57BL/6 J animals accompanied with anti-inflammatory IL-10, with less pro-inflammatory IFN-γ compared to BALB/c. Whilst the orbital tissue from immune BALB/c mice showed inflammation and adipogenesis, in contrast C57BL/6 J animals showed normal pathology. We characterised the gut microbiota using 16 S ribosomal RNA gene sequencing to explore its possible pathogenic role in the model. Despite being housed under identical conditions, we observed significantly different organisation of the microbiota (beta-diversity) in the two strains. Taxonomic differences were also noted, with C57BL/6 J showing an enrichment of Operational Taxonomic Units (OTUs) belonging to the Paludibacter and Allobaculum, followed by Limibacter, Anaerophaga and Ureaplasma genera. A higher number of genera significantly correlating with clinical features was observed in C57BL/6 J compared to BALB/c; for example, Limibacter OTUs correlated negatively with thyroid-stimulating antibodies in C57BL/6 J mice. Thus, our data suggest gut microbiota may play a pivotal immunomodulatory role that differentiates the thyroid function and orbital pathology outcome in these two inbred strains undergoing experimental GO.
Remixing the graph
Creators: name: Taraborelli, Dario
Publisher: name: figshare
Year: 2018
Subjects: subject: 80609 Information Systems Management
subject: FOS: Computer and information sciences
subject: Library and Information Studies
subject: FOS: Media and communications

description: "Remixing the graph" Slides from my invited talk at the Workshop on Open Citations, Bologna, September 3-5, 2018.
How Well Can Cosmological Parameters Be Estimated from CMB Observations?
Creators: name: Bond, J. Richard
name: Davis, Richard L.
name: Steinhardt, Paul J.
Publisher: name: arXiv
Year: 1994
Subjects: subject: Astrophysics (astro-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The CMB anisotropy depends sensitively upon the slope and amplitude of primordial density and gravitational wave fluctuations, the baryon density, the Hubble constant, the cosmological constant, the ionization history, {\it etc.} We report on recent work showing how well multi-scale measurements of the anisotropy power spectrum can resolve these factors. We identify a hypersurface in cosmic parameter space that can be accurately localized by observations, but along which the likelihood will hardly vary. Other cosmic observations will be needed to break this degeneracy.
description: 9 pages, Penn Preprint UPR-0604T
Curculio pedicularius Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Curculio
Curculio pedicularius

description: Curculio pedicularius [spec. nov.]
C. longirostris, femoribus dontatis, corpore rubro, elytris albido-subfasciatis.
Habitat in Europa.
* * * * Brevirostres femoribus dentatis.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on pages 383-384, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Fission Hindrance in hot 216Th: Evaporation Residue Measurements
Creators: name: Back, B. B.
name: Blumenthal, D. J.
name: Davids, C. N.
name: Henderson, D. J.
name: Hermann, R.
name: Hofman, D. J.
name: Jiang, C. L.
name: Penttila, H. T.
name: Wuosmaa, A. H.
Publisher: name: arXiv
Year: 1999
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The fusion evaporation-residue cross section for 32S+184W has been measured at beam energies of E_beam = 165, 174, 185, 196, 205, 215, 225, 236, 246,and 257 MeV using the ATLAS Fragment Mass Analyzer. The data are compared with Statistical Model calculations and it is found that a nuclear dissipation strength, which increases with excitation energy, is required to reproduce the excitation function. A comparison with previously published data show that the dissipation strength depends strongly on the shell structure of the nuclear system.
description: 15 pages 9 figures
General Solutions for Tunneling of Scalar Fields with Quartic Potentials in de Sitter Space
Creators: name: Sasaki, Misao
name: Stewart, Ewan D.
name: Tanaka, Takahiro
Publisher: name: arXiv
Year: 1994
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The tunneling rates for scalar fields with quartic potentials in de Sitter space in the limit of no gravitational back reaction are calculated numerically and the results are fitted by analytic formulae.
description: (Contours in Figure 1 corrected, two-dimensional fitting coefficient corrected, references added.), 16 pages, KUNS 1245
Synthesis, crystal structure, and DFT study of a new pyrido[2,3-d]pyrimidine compound 1-(4-((6-bromopyrido[2,3-d]pyrimidin-4-yl)oxy) phenyl)-3-(2,4-difluorophenyl)urea
Creators: name: Sun, Hong
name: Wang, Zhongyuan
name: Deng, Liyuan
name: Hu, Weiyin
name: Liao, Tianhui
name: Zhao, Xin
name: Zhou, Zhixu
name: Chai, Huifang
name: Zhao, Chunshen
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: In this study, 1-(4-((6-bromopyrido[2,3-d]pyrimidin-4-yl)oxy)phenyl)-3- (2,4-difluorophenyl) urea was synthesized. The structure of the compound was determined by mass spectrometry and 1H NMR, 13C NMR and FT-IR spectroscopy. The solid-state structure of the title compound was determined using single-crystal X-ray diffraction and the optimized molecular structure was determined using density functional theory calculations. The conformation of the most stable isomer that was calculated at room temperature was consistent with the conformation derived from X-ray diffraction. Hirshfeld surface analysis and 2D fingerprints were used to quantitatively analyze the intermolecular interactions and contacts in the crystal structure.
The mechanisms of human lymphoid chromosomal translocations and their medical relevance
Creators: name: Liu, Di
name: Lieber, Michael R.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: The most common human lymphoid chromosomal translocations involve concurrent failures of the recombination activating gene (RAG) complex and Activation-Induced Deaminase (AID). These are two enzymes that are normally expressed for purposes of the two site-specific DNA recombination processes: V(D)J recombination and class switch recombination (CSR). First, though it is rare, a low level of expression of AID can introduce long-lived T:G mismatch lesions at 20–600 bp fragile zones. Second, the V(D)J recombination process can occasionally fail to rejoin coding ends, and this failure may permit an opportunity for Artemis:DNA-dependent kinase catalytic subunit (DNA-PKcs) to convert the T:G mismatch sites at the fragile zones into double-strand breaks. The 20–600 bp fragile zones must be, at least transiently, in a single-stranded DNA (ssDNA) state for the first step to occur, because AID only acts on ssDNA. Here we discuss the key DNA sequence features that lead to AID action at a fragile zone, which are (a) the proximity and density of strings of cytosine nucleotides (C-strings) that cause a B/A-intermediate DNA conformation; (b) overlapping AID hotspots that contain a methyl CpG (WRCG), which AID converts to a long-lived T:G mismatch; and (c) transcription, which, though not essential, favors increased ssDNA in the fragile zone. We also summarize chromosomal features of the focal fragile zones in lymphoid malignancies and discuss the clinical relevance of understanding the translocation mechanisms. Many of the key principles covered here are also relevant to chromosomal translocations in non-lymphoid somatic cells as well.
Where Did Parshurama's Arrow Fall ?
Creators: name: RODRIGUES, TENSING CARLOS
Publisher: name: figshare
Year: 2018
Subjects: History

description: The question that I want to explore today is : what was the extent of the west coast that was uplifted ? We have said earlier that the uplifting of the Konkan coast could have happened between 10,000 and 2,000 BCE. What we are interested in is, what was exactly the extent of the land to the west of the Sahyādrī before the uplifting happened ?This question has arisen in the context of the data thrown up by the Kaṁgāvai well. As we have seen, the well lies in what was once a fresh water lake hosting a myristica swamp. And it is dated about 44,000 BCE. Kaṁgāvai is just about 15 km from the shoreline. This clearly implies that the palaeolake existed before the coast was uplifted. In fact the myristica swamp and the surrounding tropical wet evergreen forest were probably much older; they could have been there even before India parted company with Madagascar to join China ! Some expertsare of the opinion that they could be even older; that these are the vestiges of the forests that covered southern India when it was in the Equatorial zone ! [Prasad, 2009 : Evidence Of Late Palaeocene-Early Eocene Equatorial Rain Forest … , in Journal of Biosciences, 34(5)] It is difficult to arrive at any consistent conclusion. We have to wait for further geological or paleontological data to lead us.
On the Space-Time Difference of Proton and Composite Particle Emission in Central Heavy-Ion Reactions at 400 AMeV
Creators: name: Kotte, R.
name: Barz, H. W.
name: Plettner, C.
name: Neubert, W.
name: Wohlfarth, D.
name: collaboration, the FOPI
Publisher: name: arXiv
Year: 1999
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Small-angle correlations of pairs of nonidentical light charged particles produced in central collisions of heavy ions in the A=100 mass region at a beam energy of 400 AMeV are investigated with the FOPI detector system at GSI Darmstadt. The difference of longitudinal correlation functions with the relative velocity parallel and anti-parallel to the center-of-mass velocity of the pair in the central source frame is studied. This method allows extracting the apparent space-time differences of the emission of the charged particles. Comparing the correlations with results of a final-state interaction model delivers quantitative estimates of these asymmetries. Time delays as short as 1 fm/c or - alternatively - source radius differences of a few tenth fm are resolved. The strong collective expansion of the participant zone introduces not only an apparent reduction of the source radius but also a modification of the emission times. After correcting for both effects a complete sequence of space-time emission points of p, d, t, 3He, alpha particles is presented for the first time.
description: 11 pages, 12 included figures, accepted by Eur. Phys. Journ. A
Glueballs and deconfinement temperature in AdS/QCD
Creators: name: Afonin, S. S.
name: Katanaeva, A. D.
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We put forward an alternative way to estimate the deconfinement temperature in bottom-up holographic models. The deconfinement in AdS/QCD is related to the Hawking-Page phase transition, in which the critical Hawking temperature is identified with the deconfinement one in the gauge theory. The numeric estimation of the latter is only possible when the parameters of a $5D$ dual model are previously determined from consistency with other physical aspects, standardly, providing a description of the QCD resonances. The traditional way to fix parameters in the simplest AdS/QCD models is to reproduce the mass of the $ρ$ meson or the slope of the approximate radial Regge trajectory of the $ρ$ excitations. Motivated by a general idea that the slope value originates in gluodynamics, we propose calculating the deconfinement temperature using the trajectory of scalar glueballs. We consider several holographic models and use the recent idea of isospectral potentials to make an additional check of the relevance of our approach. It is demonstrated that different models from an isospectral family (i.e. the models leading to identical predictions for spectrum of hadrons with fixed quantum numbers) result in different predictions for the deconfinement temperature. This difference is found to be quite small in the scalar glueball channel but very large in the vector meson channel. The observed stability in the former case clearly favours the choice of the glueball channel for thermodynamic predictions in AdS/QCD models. For a balanced approach, we argue that either assuming $f_0(1500)$ to have a dominating component of $0^{++}$ glueball or accepting the idea of the universality in the radial Regge trajectories of light non-strange vector mesons one can reproduce the results for the deconfinement temperature obtained before in the lattice simulations in the background of non-dynamical quarks.
description: 20 pages, 3 figures. v2: matching the published version
MOESM1 of Hydrogenation of CO2 at ambient pressure catalyzed by a highly active thermostable biocatalyst
Creators: name: Schwarz, Fabian
name: Schuchmann, Kai
name: MĂźller, Volker
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 60506 Virology

description: Additional file 1: Table S1. Putative HDCR gene clusters found in bacterial genomes. Table S2. Comparison of purified enzymes catalysing the direct hydrogenation of CO2 as well as formate oxidation. Figure S1. Substrate tolerance of the HDCR from T. kivui. Figure S2. Stability of the HDCR from T. kivui.
Measuring general relativistic dragging effects in the Earth's gravitational field with ELXIS: a proposal
Creators: name: Iorio, Lorenzo
Publisher: name: arXiv
Year: 2018
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: In a geocentric kinematically rotating ecliptical coordinate system in geodesic motion through the deformed spacetime of the Sun, both the longitude of the ascending node $Ω$ and the inclination $I$ of an artificial satellite of the spinning Earth are affected by the post-Newtonian gravitoelectric De Sitter and gravitomagnetic Lense-Thirring effects. By choosing a circular orbit with $I = Ω= 90°$ for a potential new spacecraft, which we propose to name ELXIS, it would be possible to measure each of the gravitomagnetic precessions separately at a percent level, or, perhaps, even better depending on the level of accuracy of the current and future global ocean tide models since the competing classical long-term perturbations on $I,~Ω$ due to the even and odd zonal harmonics $J_\ell,~\ell=2,~3,~4,\ldots$ of the geopotential vanish. Moreover, a suitable linear combination of $I,~Ω$ would be able to cancel out the solid and ocean tidal perturbations induced by the $K_1$ tide and, at the same time, enforce the geodetic precessions yielding a secular trend of $-8.3~\textrm{milliarcseconds~per~year}$, thus strengthening the goal of a $\simeq 10^{-5}$ test of the De Sitter effect recently proposed in the literature in the case of an equatorial coordinate system. Relatively mild departures $ΔI = ΔΩ\simeq 0.01-0.1°$ from the ideal orbital configuration with $I = Ω= 90°$ are allowed. [Abridged]
description: LaTex2e, 40 pages, 2 tables, 11 figures. Two figures and one table added. Typo corrected (0 deg -> 90 deg) at pag. 3 of this draft and pag. 2 of the published version. Definition of the Sun's ecliptic longitude added in Appendix A
Field Redefinitions in String Theory as a Solution Generating Technique
Creators: name: Kaloper, Nemanja
Publisher: name: arXiv
Year: 1994
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The purpose of this work is to show that there exists an additional invariance of the $β$-function equations of string theory on $d+1$-dimensional targets with $d$ toroidal isometries. It corresponds to a shift of the dilaton field and a scaling of the lapse function, and is reminiscent of string field redefinitions. While it preserves the form of the $β$-function equations, it changes the effective action and the solutions. Thus it can be used as a solution generating technique. It is particularly interesting to note that there are field redefinitions which map solutions with non-zero string cosmological constant to those with zero cosmological constant. Several simple examples involving two- and three-dimensional black holes and black strings are provided to illustrate the role of such field redefinitions.
description: LaTeX file, 15 pages, U. of Alberta report Alberta Thy-8-94. (Revisions consist of rewording the comment on the relationship of semiclassical and exact 2d black holes, including 2 references and expanding acknowledgement)
Curculio ligustici Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Curculio
Curculio ligustici

description: Curculio ligustici [spec. nov.]
C. brevirostris, femoribus subdentatis, abdomine subovato murino.
Habitat in Ligustico Levistico.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 384, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Binary Decay of Light Nuclear Systems
Creators: name: Sanders, S. J.
name: de Toledo, A. Szanto
name: Beck, C.
Publisher: name: arXiv
Year: 1999
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: A review of the characteristic features found in fully energy-damped, binarydecay yields from light heavy-ion reactions with $20\leq A_{target} + A_{projectile}\leq 80$ is presented. The different aspects of these yields that have been used to support models of compound-nucleus (CN) fission and deep-inelastic dinucleus orbiting are highlighted. Cross section calculations based on the statistical phase space at different stages of the reaction are presented and compared to the experimental results. Although the statistical models are found to reproduce most of the observed experimental behaviors, an additional reaction component corresponding to a heavy-ion resonance or orbiting mechanism is also evident in certain systems. The system dependence of this second component is discussed. The extent to which the binary yields in very light systems $(A_{CN} \leq 32)$ can be viewed as resulting from a fusion-fission mechanism is explored. A number of unresolved questions, such as whether the different observed behaviors reflect characteristically different reaction times, are discussed.
description: 79 pages REVTeX file, 39 ps Figures included - to be publihed in Physics Report -