cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Scanning Laser Optical Tomography Resolves Structural Plasticity during Regeneration in an Insect Brain
Creators: name: Eickhoff, Rene
name: Lorbeer, Raoul-Amadeus
name: Scheiblich, Hannah
name: Heisterkamp, Alexander
name: Meyer, Heiko
name: Stern, Michael
name: Bicker, Gerd
Publisher: name: San Francisco : Public Library Science
Year: 2012
Subjects: subject: projection tomography
subject: schistocerca-gregaria
subject: gene-expression
subject: mushroom bodies
subject: axonal regeneration
subject: locusta-migratoria
subject: tympanal nerve
subject: desert locust
subject: antennal lobe
subject: microscopy
subject: Dewey Decimal Classification::600 | Technik::610 | Medizin, Gesundheit
subject: Dewey Decimal Classification::500 | Naturwissenschaften::570 | Biowissenschaften, Biologie
subject: Dewey Decimal Classification::500 | Naturwissenschaften::510 | Mathematik
subject: Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik

description: Background: Optical Projection Tomography (OPT) is a microscopic technique that generates three dimensional images from whole mount samples the size of which exceeds the maximum focal depth of confocal laser scanning microscopes. As an advancement of conventional emission-OPT, Scanning Laser Optical Tomography (SLOTy) allows simultaneous detection of fluorescence and absorbance with high sensitivity. In the present study, we employ SLOTy in a paradigm of brain plasticity in an insect model system. Methodology: We visualize and quantify volumetric changes in sensory information procession centers in the adult locust, Locusta migratoria. Olfactory receptor neurons, which project from the antenna into the brain, are axotomized by crushing the antennal nerve or ablating the entire antenna. We follow the resulting degeneration and regeneration in the olfactory centers (antennal lobes and mushroom bodies) by measuring their size in reconstructed SLOTy images with respect to the untreated control side. Within three weeks post treatment antennal lobes with ablated antennae lose as much as 60% of their initial volume. In contrast, antennal lobes with crushed antennal nerves initially shrink as well, but regain size back to normal within three weeks. The combined application of transmission-and fluorescence projections of Neurobiotin labeled axotomized fibers confirms that recovery of normal size is restored by regenerated afferents. Remarkably, SLOTy images reveal that degeneration of olfactory receptor axons has a trans-synaptic effect on second order brain centers and leads to size reduction of the mushroom body calyx. Conclusions: This study demonstrates that SLOTy is a suitable method for rapid screening of volumetric plasticity in insect brains and suggests its application also to vertebrate preparations.
Better Together: Technical Services & Public Services
Creators: name: Renner, Barbara Rochen
name: Richardson, Lee M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: Public services and cataloging/metadata can work together in creative ways, contributing unique skill sets to improve projects and services. This presentation shares a collaboration between a health sciences library liaison and a cataloger/metadata librarian to improve three public services projects and one long-term project involving several library departments and campus partners.
Ventilation and air quality in city blocks using large-eddy simulation-urban planning perspective
Creators: name: Kurppa, Mona
name: Hellsten, Antti
name: Auvinen, Mikko
name: Raasch, Siegfried
name: Vesala, Timo
name: Järvi, Leena
Publisher: name: Basel : MDPI AG
Year: 2018
Subjects: subject: Air quality
subject: Dispersion
subject: LES
subject: Urban planning
subject: Ventilation
subject: Atmospheric movements
subject: Dispersion (waves)
subject: Forestry
subject: Large eddy simulation
subject: Pollution
subject: Surface roughness
subject: Urban transportation
subject: Atmospheric stability
subject: Atmospheric stratification
subject: Concentration levels
subject: High resolution simulations
subject: Mean concentrations
subject: Meteorological condition
subject: Pollutant transport
subject: Traffic-related emissions
subject: Air pollution
subject: air quality
subject: atmospheric pollution
subject: comparative study
subject: diffusion
subject: emission control
subject: large eddy simulation
subject: traffic emission
subject: urban planning
subject: ventilation
subject: Dewey Decimal Classification::500 | Naturwissenschaften::550 | Geowissenschaften

description: Buildings and vegetation alter the wind and pollutant transport in urban environments. This comparative study investigates the role of orientation and shape of perimeter blocks on the dispersion and ventilation of traffic-related air pollutants, and the street-level concentrations along a planned city boulevard. A large-eddy simulation (LES) model PALM is employed over a highly detailed representation of the urban domain including street trees and forested areas. Air pollutants are represented by massless and passive particles (non-reactive gases), which are released with traffic-related emission rates. High-resolution simulations for four different city-block-structures are conducted over a 8.2 km2 domain under two contrasting inflow conditions with neutral and stable atmospheric stratification corresponding the general and wintry meteorological conditions. Variation in building height together with multiple cross streets along the boulevard improves ventilation, resulting in 7-9% lower mean concentrations at pedestrian level. The impact of smaller scale variability in building shape was negligible. Street trees further complicate the flow and dispersion. Notwithstanding the surface roughness, atmospheric stability controls the concentration levels with higher values under stably stratified inflow. Little traffic emissions are transported to courtyards. The results provide urban planners direct information to reduce air pollution by proper structural layout of perimeter blocks. © 2018 by the authors.
Tidal evolution of close-in exoplanets in co-orbital configurations
Creators: name: Rodríguez, Adrián
name: Giuppone, Cristian A.
name: Michtchenko, Tatiana A.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: In this paper, we study the behavior of a pair of co-orbital planets, both orbiting a central star on the same plane and undergoing tidal interactions. Our goal is to investigate final orbital configurations of the planets, initially involved in the 1/1 mean-motion resonance (MMR), after long-lasting tidal evolution. The study is done in the form of purely numerical simulations of the exact equations of motions accounting for gravitational and tidal forces. The results obtained show that, at least for equal mass planets, the combined effects of the resonant and tidal interactions provoke the orbital instability of the system, often resulting in collision between the planets. We first discuss the case of two hot-super-Earth planets, whose orbital dynamics can be easily understood in the frame of our semi-analytical model of the 1/1 MMR. Systems consisting of two hot-Saturn planets are also briefly discussed.
description: 18 pages, 8 figures. Accepted for publication in Celestial Mechanics and Dynamical Astronomy
The D(D-3)-anyon chain: integrable boundary conditions and excitation spectra
Creators: name: Finch, Peter E.
name: Frahm, Holger
Publisher: name: Bristol : IOP Publishing Ltd.
Year: 2013
Subjects: subject: invariant partition-functions
subject: non-abelian anyons
subject: operator content
subject: finite-size
subject: conformal-invariance
subject: quantum computation
subject: critical exponents
subject: critical systems
subject: dynkin diagrams
subject: lattice models
subject: Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik

description: Chains of interacting non-Abelian anyons with local interactions invariant under the action of the Drinfeld double of the dihedral group D-3 are constructed. Formulated as a spin chain the Hamiltonians are generated from commuting transfer matrices of an integrable vertex model for periodic and braided as well as open boundaries. A different anyonic model with the same local Hamiltonian is obtained within the fusion path formulation. This model is shown to be related to an integrable fusion interaction round the face model. Bulk and surface properties of the anyon chain are computed from the Bethe equations for the spin chain. The low-energy effective theories and operator content of the models (in both the spin chain and fusion path formulation) are identified from analytical and numerical studies of the finite-size spectra. For all boundary conditions considered the continuum theory is found to be a product of two conformal field theories. Depending on the coupling constants the factors can be a Z(4) parafermion or a M-(5,M-6) minimal model.
A 10-year retrospective of research in health mass media campaigns: Where do we go from here?
Creators: name: Noar, Seth M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Mass media campaigns have long been a tool for promoting public health. How effective are such campaigns in changing health-related attitudes and behaviors, however, and how has the literature in this area progressed over the past decade? The purpose of the current article is threefold. First, I discuss the importance of health mass media campaigns and raise the question of whether they are capable of effectively impacting public health. Second, I review the literature and discuss what we have learned about the effectiveness of campaigns over the past 10 years. Finally, I conclude with a discussion of possible avenues for the health campaign literature over the next 10 years. The overriding conclusion is the following: The literature is beginning to amass evidence that targeted, well-executed health mass media campaigns can have small-to-moderate effects not only on health knowledge, beliefs, and attitudes, but on behaviors as well, which can translate into major public health impact given the wide reach of mass media. Such impact can only be achieved, however, if principles of effective campaign design are carefully followed.
Anomalous dimensions of the double parton fragmentation functions
Creators: name: Fleming, Sean
name: Leibovich, Adam K.
name: Mehen, Thomas
name: Rothstein, Ira Z.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Double parton fragmentation is a process in which a pair of partons produced in the short-distance process hadronize into the final state hadron. This process is important for quarkonium production when the transverse momentum is much greater than the quark mass. Resummation of logarithms of the ratio of these two scales requires the evolution equations for double parton fragmentation functions (DPFF). In this paper we complete the one-loop evaluation of the anomalous dimensions for the DPFF. We also consider possible mixing between the DPFF and single parton power suppressed gluon fragmentation and show that such effects are sub-leading.
description: 10 pages
A human rights approach to the health implications of food and nutrition insecurity
Creators: name: Meier, Ben
Publisher: name: BioMed Central
Year: 2017

description: Abstract Food and nutrition insecurity continues to pose a serious global challenge, reflecting government shortcomings in meeting international obligations to ensure the availability, accessibility, and quality of food and to ensure the highest attainable standard of health of their peoples. With global drivers like climate change, urbanization, greater armed conflict, and the globalization of unhealthy diet, particularly in under-resourced countries, food insecurity is rapidly becoming an even greater challenge for those living in poverty. International human rights law can serve a critical role in guiding governments that are struggling to protect the health of their populations, particularly among the most susceptible groups, in responding to food and nutrition insecurity. This article explores and advocates for a human rights approach to food and nutrition security, specifically identifying legal mechanisms to “domesticate” relevant international human rights standards through national policy. Recognizing nutrition security as a determinant of public health, this article recognizes the important links between the four main elements of food security (i.e., availability, stability, utilization, and access) and the normative attributes of the right to health and the right to food (i.e., availability, accessibility, affordability, and quality). In drawing from the evolution of international human rights instruments, official documents issued by international human rights treaty bodies, as well as past scholarship at the intersection of the right to health and right to food, this article interprets and articulates the intersectional rights-based obligations of national governments in the face of food and nutrition insecurity.
Gauge Mediation Models with Vectorlike Matters at the LHC
Creators: name: Endo, Motoi
name: Hamaguchi, Koichi
name: Ishikawa, Kazuya
name: Iwamoto, Sho
name: Yokozaki, Norimi
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Gauge mediation model with vectorlike matters (V-GMSB) is one of the few viable SUSY models that explains the 126 GeV Higgs boson mass and the muon anomalous magnetic moment simultaneously. We explore exclusion bounds on V-GMSB model from latest LHC SUSY searches.
description: 21 pages, 8 figures
Position-dependent diffusion of light in disordered waveguides
Creators: name: Yamilov, Alexey G.
name: Sarma, Raktim
name: Redding, Brandon
name: Payne, Ben
name: Noh, Heeso
name: Cao, Hui
Publisher: name: arXiv
Year: 2013
Subjects: subject: Optics (physics.optics)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: Diffusion has been widely used to describe a random walk of particles or waves, and it requires only one parameter -- the diffusion constant. For waves, however, diffusion is an approximation that disregards the possibility of interference. Anderson localization, which manifests itself through a vanishing diffusion coefficient in an infinite system, originates from constructive interference of waves traveling in loop trajectories -- pairs of time-reversed paths returning to the same point. In an open system of finite size, the return probability through such paths is reduced, particularly near the boundary where waves may escape. Based on this argument, the self-consistent theory of localization and the supersymmetric field theory predict that the diffusion coefficient varies spatially inside the system. A direct experimental observation of this effect is a challenge because it requires monitoring wave transport inside the system. Here, we fabricate two-dimensional photonic random media and probe position-dependent diffusion inside the sample from the third dimension. By varying the geometry of the system or the dissipation which also limits the size of loop trajectories, we are able to control the renormalization of the diffusion coefficient. This work shows the possibility of manipulating diffusion via the interplay of localization and dissipation.
description: 24 pages, 6 figures
Aria
Creators: name: Becherer
Publisher: name: Zenodo
Year: 1956
Subjects: Biodiversity
Taxonomy

description: S. Aria X Chamaemespilus Cat. 142. l: Ob Salvan (Coquoz). - 2: Saille-Bougnonneob Saillon (P.); ob Ayent (P.). - 3-3a: Simplonplateau, bei den Galerien und um das Hospiz (Melly).
description: Published as part of Becherer, 1956, Florae Vallesiacae Supplementum, pp. 1-556 in Denkschriften der Schweizerischen Naturforschenden Gesellschaft 71 on pages 1-556
Testing the organizational theory of innovation implementation effectiveness in a community pharmacy medication management program: a hurdle regression analysis
Creators: name: Turner, Kea
name: Weinberger, Morris
name: Shea, Christopher
name: Stover, Angela M
name: Patti, Michael
name: Farley, Joel
name: Renfro, Chelsea
name: Ferreri, Stefanie
name: Trogdon, Justin G
name: Ray, Neepa
Publisher: name: BioMed Central
Year: 2018

description: Abstract
                Background
                Many state Medicaid programs are implementing pharmacist-led medication management programs to improve outcomes for high-risk beneficiaries. There are a limited number of studies examining implementation of these programs, making it difficult to assess why program outcomes might vary across organizations. To address this, we tested the applicability of the organizational theory of innovation implementation effectiveness to examine implementation of a community pharmacy Medicaid medication management program.
                Methods
                We used a hurdle regression model to examine whether organizational determinants, such as implementation climate and innovation-values fit, were associated with effective implementation. We defined effective implementation in two ways: implementation versus non-implementation and program reach (i.e., the proportion of the target population that received the intervention). Data sources included an implementation survey administered to participating community pharmacies and administrative data.
                Results
                The findings suggest that implementation climate is positively and significantly associated with implementation versus non-implementation (AME = 2.65, p < 0.001) and with program reach (AME = 5.05, p = 0.001). Similarly, the results suggest that innovation-values fit is positively and significantly associated with implementation (AME = 2.17, p = 0.037) and program reach (AME = 11.79, p < 0.001). Some structural characteristics, such as having a clinical pharmacist on staff, were significant predictors of implementation and program reach whereas other characteristics, such as pharmacy type or prescription volume, were not.
                Conclusions
                Our study supported the use of the organizational theory of innovation implementation effectiveness to identify organizational determinants that are associated with effective implementation (e.g., implementation climate and innovation-values fit). Unlike broader environmental factors or structural characteristics (e.g., pharmacy type), implementation climate and innovation-values fit are modifiable factors and can be targeted through intervention—a finding that is important for community pharmacy practice. Additional research is needed to determine what implementation strategies can be used by community pharmacy leaders and practitioners to develop a positive implementation climate and innovation-values fit for medication management programs.
Long transient dynamics in the Anderson-Holstein model out of equilibrium
Creators: name: Albrecht, Klaus Ferdinand
name: Martin-Rodero, Alvaro
name: Monreal, Rosa Carmina
name: Mühlbacher, Lothar
name: Yeyati, Alfredo Levy
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We calculate the time dependent nonequilibrium current through a single level quantum dot strongly coupled to a vibrational mode. The nonequilibrium real time dynamics caused by an instantaneous coupling of the leads to the quantum dot is discussed using an approximate method. The approach, which is specially designed for the strong polaronic regime, is based on the so-called polaron tunneling approximation. Considering different initial dot occupations, we show that a common steady state is reached after times much larger than the typical electron tunneling times due to a polaron blocking effect in the dot charge. A direct comparison is made with numerically exact data, showing good agreement for the time scales accessible by the diagrammatic Monte Carlo simulation method.
A proteomic analysis of chondrogenic, osteogenic and tenogenic constructs from ageing mesenchymal stem cells
Creators: name: Collins, John
name: Proctor, Carole
name: Loughlin, John
name: Peffers, Mandy J.
name: Clegg, Peter D.
Publisher: name: BioMed Central
Year: 2016

description: Abstract Background Mesenchymal stem cells (MSCs) have prospective applications in regenerative medicine and tissue engineering but to what extent phenotype and differentiation capacity alter with ageing is uncertain. Consequently, any loss in functionality with age would have profound consequences for the maintenance of tissue viability and the quality of tissues. Proteomics enables the set of proteins responsible for a particular cell phenotype to be identified, as well as enabling insights into mechanisms responsible for age-related alterations in musculoskeletal tissues. Few proteomic studies have been undertaken regarding age-related effects on tissue engineered into cartilage and bone, and none for tendon. This study provides a proteome inventory for chondrogenic, osteogenic and tenogenic constructs synthesised from human MSCs, and elucidates proteomic alterations as a consequence of donor age. Methods Human bone-marrow derived MSCs from young (n = 4, 21.8 years ± 2.4SD) and old (n = 4, 65.5 years ± 8.3SD) donors were used to make chondrogenic, osteogenic and tenogenic tissue-engineered constructs. We utilised an analytical method relying on extracted peptide intensities as a label-free approach for peptide quantitation by liquid chromatography–mass spectrometry. Results were validated using western blotting. Results We identified proteins that were differentially expressed with ageing; 128 proteins in chondrogenic constructs, 207 in tenogenic constructs and four in osteogenic constructs. Differentially regulated proteins were subjected to bioinformatic analysis to ascertain their molecular functions and the signalling pathways. For all construct types, age-affected proteins were involved in altered cell survival and death, and antioxidant and cytoskeletal changes. Energy and protein metabolism were the principle pathways affected in tenogenic constructs, whereas lipid metabolism was strongly affected in chondrogenic constructs and mitochondrial dysfunction in osteogenic constructs. Conclusions Our results imply that further work on MSC-based therapeutics for the older population needs to focus on oxidative stress protection. The differentially regulated proteome characterised by this study can potentially guide translational research specifically aimed at effective clinical interventions.
The acute effect of exercise and nutrition on respiratory exchange ratio in women
Creators: name: Trexler, Eric
name: Wingfield, Hailee L
name: Smith-Ryan, Abbie
name: Roelofs, Erica J
name: Melvin, Malia N
Publisher: name: BioMed Central
Year: 2014

description: Few studies exist evaluating metabolic responses to exercise and nutrition in women. Understanding sex-specific fuel differences may improve exercise prescription. PURPOSE: To examine the effect of exercise modality and pre-exercise carbohydrate (CHO) or protein (PRO) ingestion on respiratory exchange ratio (RER) in women.
Infrared Parallaxes of Young Field Brown Dwarfs and Connections to Directly Imaged Gas-Giant Exoplanets
Creators: name: Liu, Michael C.
name: Dupuy, Trent J.
name: Allers, Katelyn N.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We have measured high-precision parallaxes for a large sample of candidate young (~10-100 Myr) and intermediate-age (~100-600 Myr) ultracool dwarfs, with spectral types ranging from M8 to T2.5. These objects are compelling benchmarks for substellar evolution and ultracool atmospheres at lower surface gravities (i.e., masses) than most of the field population. We find that the absolute magnitudes of our young sample can be systematically offset from ordinary (older) field dwarfs, with the young late-M objects being brighter and the young/dusty mid-L (L3-L6.5) objects being fainter, especially at J band. Thus, we conclude the "underluminosity" of the young planetary-mass companions HR 8799b and 2MASS J1207-39b compared to field dwarfs is also manifested in young free-floating brown dwarfs, though the effect is not as extreme. At the same time, some young objects over the full spectral type range of our sample are similar to field objects, and thus a simple correspondence between youth and magnitude offset relative to the field population appears to be lacking. Comparing the kinematics of our sample to nearby stellar associations and moving groups, we identify several new moving group members, including the first free-floating L dwarf in the AB Dor moving group, 2MASS J0355+11. Altogether, the effects of surface gravity (age) and dust content on the magnitudes and colors of substellar objects appear to be degenerate.
description: Proceedings of Cool Stars 17
Lactobacillus GG in inducing and maintaining remission of Crohn's disease
Creators: name: Sartor, Balfour
Publisher: name: BioMed Central Ltd
Year: 2004

description: Abstract Background Experimental studies have shown that luminal antigens are involved in chronic intestinal inflammatory disorders such as Crohn's disease and ulcerative colitis. Alteration of the intestinal microflora by antibiotic or probiotic therapy may induce and maintain remission. The aim of this randomized, placebo-controlled trial was to determine the effect of oral Lactobacillus GG (L. GG) to induce or maintain medically induced remission. Methods Eleven patients with moderate to active Crohn's disease were enrolled in this trial to receive either L. GG (2 × 109 CFU/day) or placebo for six months. All patients were started on a tapering steroid regime and received antibiotics for the week before the probiotic/placebo medication was initiated. The primary end point was sustained remission, defined as freedom from relapse at the 6 months follow-up visit. Relapse was defined as an increase in CDAI of >100 points. Results 5/11 patients finished the study, with 2 patients in each group in sustained remission. The median time to relapse was 16 ± 4 weeks in the L. GG group and 12 ± 4.3 weeks in the placebo group (p = 0.5). Conclusion In this study we could not demonstrate a benefit of L. GG in inducing or maintaining medically induced remission in CD.
title: Bilderglosse 2: Hüte-Bilder (alte und neuere)
Creators: name: Hinz, Berthold
Publisher: name: University Library Heidelberg
Year: 2016

description: kritische berichte - Zeitschrift für Kunst- und Kulturwissenschaften, Bd. 6, Nr. 6 (1978): kritische berichte, Beginn und Erscheinungsfrequenz: Ausgaben pro Band: 4
Students Working in the Cataloging Department
Creators: name: Gunther, Wanda
name: Richardson, Lee M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: Cataloging departments don’t often consider hiring students outside of library science due to the amount of training and oversight required for much of the work done in cataloging. However, there are many tasks in a cataloging department a student can do without a big investment in training. This poster will share experiences of two academic library cataloging departments and give concrete examples of work successfully done by undergraduate students without a background in libraries.
Aria
Creators: name: Becherer
Publisher: name: Zenodo
Year: 1956
Subjects: Biodiversity
Taxonomy

description: S. Aria X Chamaemespilus X Mougeotii - 2: Bei Ayent (P., det. M. Moreillon).
description: Published as part of Becherer, 1956, Florae Vallesiacae Supplementum, pp. 1-556 in Denkschriften der Schweizerischen Naturforschenden Gesellschaft 71 on pages 1-556
UTILIZATION OF ADDITIVE MANUFACTURING IN THE DEVELOPMENT OF STATIONARY DIFFUSION SYSTEMS FOR AEROENGINE CENTRIFUGAL COMPRESSORS
Creators: name: Coon, Adam Thomas
Publisher: name: Purdue University Graduate School
Year: 2023
Subjects: Aerodynamics (excl. hypersonic aerodynamics)

description: Rising costs and volatility in aviation fuel and increased regulations resulting from climate change concerns have driven gas turbine engine manufacturers to focus on reducing fuel consumption. Implementing centrifugal compressors as the last stage in an axial engine architecture allows for reduced core diameters and higher fuel efficiencies. However, a centrifugal compressor's performance relies heavily on its stationary diffusion system. Furthermore, the highly unsteady and turbulent flow field exhibited in the diffusion system often causes CFD models to fall short of reality. Therefore, rapid validation is required to match the speed at which engineers can simulate different diffuser designs utilizing CFD. One avenue for this is through the use of additive manufacturing in centrifugal compressor experimental research. This study focused on implementing a new generation of the Centrifugal Stage for Aerodynamic Research (CSTAR) at the Purdue Compressor Research Lab that utilizes an entirely additively manufactured diffusion system. In addition, the new configuration was used to showcase the benefits of additive manufacturing (AM) in evaluating diffusion components. Two diffusion systems were manufactured and assessed. The Build 2 diffusion system introduced significant modifications to the diffusion system compared to the Build 1 design. The modifications included changes to the diffuser vane geometry, endwall divergence, and increased deswirl pinch and vane geometries. The Build 2 diffusion system showed performance reductions in total and static pressure rise, flow range, and efficiencies. These results were primarily attributed to the changes made to the Build 2 diffuser. The end wall divergence resulted in end wall separation that caused increased losses. The changes to the diffuser vane resulted in increased throat blockage and lower pressure rise and mass flow rate. In addition to the experimental portion of this study, a computational study was conducted to study the design changes made to the Build 2 diffusion system. A speedline at 100% corrected rotational speed was solved, and the results were compared to experimental data. The simulated data matched the overall stage and diffusion system performance relatively well, but the internal flow fields of the diffusion components, namely the diffuser, were not well predicted. This was attributed to 16 using the SST turbulence model over BSL EARSM. The BSL EARSM model more accurately predicted the diffuser flow field to the SST model.
Portfolio Management Approach in Trade Credit Decision Making
Creators: name: Michalski, Grzegorz
Publisher: name: arXiv
Year: 2013
Subjects: subject: Portfolio Management (q-fin.PM)
subject: General Finance (q-fin.GN)
subject: Risk Management (q-fin.RM)
subject: FOS: Economics and business
subject: 91G50

description: The basic financial purpose of an enterprise is maximization of its value. Trade credit management should also contribute to realization of this fundamental aim. Many of the current asset management models that are found in financial management literature assume book profit maximization as the basic financial purpose. These book profitbased models could be lacking in what relates to another aim (i.e., maximization of enterprise value). The enterprise value maximization strategy is executed with a focus on risk and uncertainty. This article presents the consequences that can result from operating risk that is related to purchasers using payment postponement for goods and/or services. The present article offers a method that uses portfolio management theory to determine the level of accounts receivable in a firm. An increase in the level of accounts receivables in a firm increases both net working capital and the costs of holding and managing accounts receivables. Both of these decrease the value of the firm, but a liberal policy in accounts receivable coupled with the portfolio management approach could increase the value. Efforts to assign ways to manage these risks were also undertaken; among them, special attention was paid to adapting assumptions from portfolio theory as well as gauging the potential effect on the firm value.
description: no coments
Treatment of pancreatic ductal adenocarcinoma with tumor antigen specific-targeted delivery of paclitaxel loaded PLGA nanoparticles
Creators: name: Grover, Kajal R
name: Fowler, Anthony J
name: Yazdanifar, Mahboubeh
name: Zhou, Ru
name: Mukherjee, Pinku
name: Williams, Chandra D
name: Wu, Shu-ta
name: Fessler, Adam B
name: Ogle, Joshua D
name: Allen, Bailey C
name: Garmon, Corey B
name: Ogle, Craig A
Publisher: name: BioMed Central
Year: 2018

description: Abstract Background Pancreatic ductal adenocarcinoma (PDA) remains the most aggressive cancers with a 5-year survival below 10%. Systemic delivery of chemotherapy drugs has severe side effects in patients with PDA and does not significantly improve overall survival rate. It is highly desirable to advance the therapeutic efficacy of chemotherapeutic drugs by targeting their delivery and increasing accumulation at the tumor site. MUC1 is a membrane-tethered glycoprotein that is aberrantly overexpressed in > 80% of PDA thus making it an attractive antigenic target. Methods Poly lactic-co-glycolic acid nanoparticles (PLGA NPs) conjugated to a tumor specific MUC1 antibody, TAB004, was used as a nanocarrier for targeted delivery into human PDA cell lines in vitro and in PDA tumors in vivo. The PLGA NPs were loaded with fluorescent imaging agents, fluorescein diacetate (FDA) and Nile Red (NR) or isocyanine green (ICG) for in vitro and in vivo imaging respectively or with a chemotherapeutic drug, paclitaxel (PTX) for in vitro cytotoxicity assays. Confocal microscopy was used to visualize internalization of the nanocarrier in vitro in PDA cells with high and low MUC1 expression. The in vivo imaging system (IVIS) was used to visualize in vivo tumor targeting of the nanocarrier. MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) assay was used to determine in vitro cell survival of cells treated with PTX-loaded nanocarrier. One-sided t-test comparing treatment groups at each concentration and two-way ANOVAs comparing internalization of antibody and PLGA nanoparticles. Results In vitro, TAB004-conjugated ICG-nanocarriers were significantly better at internalizing in PDA cells than its non-conjugated counterpart. Similarly, TAB004-conjugated PTX-nanocarriers were significantly more cytotoxic in vitro against PDA cells than its non-conjugated counterpart. In vivo, TAB004-conjugated ICG-nanocarriers showed increased accumulation in the PDA tumor compared to the non-conjugated nanocarrier while sparing normal organs. Conclusions The study provides promising data for future development of a novel MUC1-targeted nanocarrier for direct delivery of imaging agents or drugs into the tumor microenvironment.
Effect of calories-only vs physical activity calorie expenditure labeling on lunch calories purchased in worksite cafeterias
Creators: name: Gras-Najjar, Julie
name: Olsson, Emily
name: Hales, Derek
name: Gizlice, Ziya
name: Viera, Anthony J
name: Noar, Seth M
name: Tuttle, Laura
name: Linnan, Laura
name: Lin, Feng-Chang
name: Ammerman, Alice
Publisher: name: BioMed Central
Year: 2019

description: Abstract
                Background
                Calorie labeling on restaurant menus is a public health strategy to guide consumer ordering behaviors, but effects on calories purchased have been minimal. Displaying labels communicating the physical activity required to burn calories may be a more effective approach, but real-world comparisons are needed.
                Methods
                In a quasi-experimental study, we examined the effect of physical activity calorie expenditure (PACE) food labels compared to calorie-only labels on point-of-decision food purchasing in three worksite cafeterias in North Carolina. After a year of quarterly baseline data collection, one cafeteria prominently displayed PACE labels, and two cafeterias prominently displayed calorie-only labels. Calories from foods purchased in the cafeteria during lunch were assessed over 2 weeks every 3 months for 2 years by photographs of meals. We compared differences in purchased calorie estimates before and after the labeling intervention was introduced using longitudinal generalized linear mixed model regressions that included a random intercept for each participant.
                Results
                In unadjusted models comparing average meal calories after vs before labeling, participants exposed to PACE labels purchased 40.4 fewer calories (P = 0.002), and participants exposed to calorie-only labels purchased 38.2 fewer calories (P = 0.0002). The small difference of 2 fewer calories purchased among participants exposed to PACE labeling vs calorie-only labeling was not significant (P = 0.90). Models adjusting for age, sex, race, occupation, numeracy level, and health literacy level did not change estimates appreciably.
                Conclusion
                In this workplace cafeteria setting, PACE labeling was no more effective than calorie-only labeling in reducing lunchtime calories purchased.
TNFA deletion alters apoptosis as well as caspase 3 and 4 expression during otitis media
Creators: name: Hernandez, Michelle
name: Ebmeyer, Joerg
name: Leichtle, Anke
name: Wasserman, Stephen I
name: Broide, David
name: Ryan, Allen F
name: Ebmeyer, Umay
name: Sudhoff, Holger
name: Husseman, Jacob
name: Pak, Kwang
Publisher: name: BioMed Central Ltd
Year: 2011

description: Abstract Background Tumor necrosis factor (TNFA) is the canonical member of the TNF superfamily, which plays a major role in both inflammation and apoptosis. To evaluate the role of TNFs in otitis media (OM), the most common disease of childhood, we evaluated middle ear (ME) expression of genes encoding the TNF and TNF receptor superfamilies during bacterial OM in the mouse, characterized OM in TNFA-deficient mice, and assessed apoptosis during OM in normal versus TNF-deficient MEs. Results TNFs and TNF receptors were broadly regulated during OM, with TNFA showing the highest level of up-regulation. TNF deficient mice exhibited mucosal hyperplasia even in the absence of infection and exuberant growth of the mucosa during OM, including the formation of mucosal polyps. Mucosal recovery during OM was also delayed, in parallel with a delay in mucosal apoptosis and reduced caspase gene expression. Conclusions The TNF and TNF receptor superfamilies mediate both inflammation and apoptosis during OM. TNF appears to be critical for the maintenance of mucosal architecture in both the normal and infected ME, since excessive accumulation of mucosal tissue is seen in TNFA-/- MEs both before and after bacterial inoculation of the ME. TNFA is also required for appropriate regulation of caspase genes.
Flow Motifs Reveal Limitations of the Static Framework to Represent Human interactions
Creators: name: Rocha, Luis Enrique Correa
name: Blondel, Vincent D
Publisher: name: arXiv
Year: 2013
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Social and Information Networks (cs.SI)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: Quantitative Methods (q-bio.QM)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences
subject: FOS: Biological sciences

description: Networks are commonly used to define underlying interaction structures where infections, information, or other quantities may spread. Although the standard approach has been to aggregate all links into a static structure, some studies suggest that the time order in which the links are established may alter the dynamics of spreading. In this paper, we study the impact of the time ordering in the limits of flow on various empirical temporal networks. By using a random walk dynamics, we estimate the flow on links and convert the original undirected network (temporal and static) into a directed flow network. We then introduce the concept of flow motifs and quantify the divergence in the representativity of motifs when using the temporal and static frameworks. We find that the regularity of contacts and persistence of vertices (common in email communication and face-to-face interactions) result on little differences in the limits of flow for both frameworks. On the other hand, in the case of communication within a dating site (and of a sexual network), the flow between vertices changes significantly in the temporal framework such that the static approximation poorly represents the structure of contacts. We have also observed that cliques with 3 and 4 vertices con- taining only low-flow links are more represented than the same cliques with all high-flow links. The representativity of these low-flow cliques is higher in the temporal framework. Our results suggest that the flow between vertices connected in cliques depend on the topological context in which they are placed and in the time sequence in which the links are established. The structure of the clique alone does not completely characterize the potential of flow between the vertices.
Biological insights from 108 schizophrenia-associated genetic loci
Creators: name: Perkins, Diana
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.
Molecular portraits of human breast tumours
Creators: name: Williams, Cheryl
name: Johnsen, Hilde
name: Akslen, Lars A.
name: Eisen, Michael B.
name: Brown, Patrick O.
name: Rees, Christian A.
name: Ross, Douglas T.
name: Sorlie, Therese
name: Jeffrey, Stefanie S.
name: van de Rijn, Matt
name: Pollack, Jonathan R.
name: Perou, Charles M.
name: Botstein, David
name: Borresen-Dale, Anne-Lise
name: Zhu, Shirley X.
name: Pergamenschikov, Alexander
name: Lonning, Per E.
name: Fluge, Oystein
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: Human breast tumours are diverse in their natural history and in
their responsiveness to treatments1. Variation in transcriptional
programs accounts for much of the biological diversity of human
cells and tumours. In each cell, signal transduction and regulatory
systems transduce information from the cell's identity to its
environmental status, thereby controlling the level of expression
of every gene in the genome. Here we have characterized variation
in gene expression patterns in a set of 65 surgical specimens of
human breast tumours from 42 different individuals, using
complementary DNA microarrays representing 8,102 human
genes. These patterns provided a distinctive molecular portrait
of each tumour. Twenty of the tumours were sampled twice,
before and after a 16-week course of doxorubicin chemotherapy,
and two tumours were paired with a lymph node metastasis from
the same patient. Gene expression patterns in two tumour
samples from the same individual were almost always more
similar to each other than either was to any other sample. Sets
of co-expressed genes were identi®ed for which variation in
messenger RNA levels could be related to speci®c features of
physiological variation. The tumours could be classi®ed into
subtypes distinguished by pervasive differences in their gene
expression patterns.
Discovery, Timing, and Multiwavelength Observations of the Black Widow Millisecond Pulsar PSR J1555-2908
Creators: name: Ray, Paul S.
name: Nieder, Lars
name: Clark, Colin J.
name: Ransom, Scott M.
name: Cromartie, H. Thankful
name: Frail, Dale A.
name: Mooley, Kunal P.
name: Intema, Huib
name: Jagannathan, Preshanth
name: Demorest, Paul
name: Stovall, Kevin
name: Halpern, Jules P.
name: Deneva, Julia
name: Guillot, Sebastien
name: Kerr, Matthew
name: Swihart, Samuel J.
name: Bruel, Philippe
name: Stappers, Ben W.
name: Lyne, Andrew
name: Mickaliger, Mitch
name: Camilo, Fernando
name: Ferrara, Elizabeth C.
name: Wolff, Michael T.
name: Michelson, P.F.
Publisher: name: London : Institute of Physics Publ.
Year: 2022
Subjects: subject: Large-Area Telescope
subject: Gravitational-Waves
subject: Ray;Searches
subject: Binaries
subject: Software
subject: Sky
subject: Dewey Decimal Classification::500 | Naturwissenschaften::520 | Astronomie, Kartographie

description: We report the discovery of PSR J1555-2908, a 1.79 ms radio and gamma-ray pulsar in a 5.6 hr binary system with a minimum companion mass of 0.052 M ⊙. This fast and energetic ( Ė=3×1035 erg s-1) millisecond pulsar was first detected as a gamma-ray point source in Fermi Large Area Telescope (LAT) sky survey observations. Guided by a steep-spectrum radio point source in the Fermi error region, we performed a search at 820 MHz with the Green Bank Telescope that first discovered the pulsations. The initial radio pulse timing observations provided enough information to seed a search for gamma-ray pulsations in the LAT data, from which we derive a timing solution valid for the full Fermi mission. In addition to the discovery and timing of radio and gamma-ray pulsations, we searched for X-ray pulsations using NICER but no significant pulsations were detected. We also obtained time-series r-band photometry that indicates strong heating of the companion star by the pulsar wind. Material blown off the heated companion eclipses the 820 MHz radio pulse during inferior conjunction of the companion for ≈10% of the orbit, which is twice the angle subtended by its Roche lobe in an edge-on system. © 2022. The Author(s). Published by the American Astronomical Society.