cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Epigenetic Mechanisms of Atherosclerosis Etiopathogenesis
Creators: name: R.N. Mustafin
Publisher: name: Opera Medica et Physiologica
Year: 2024
Subjects: atherosclerosis
epigenetic factors
long noncoding RNAs
microRNA
retroelements

description: Epigenetic regulation of spatiotemporal gene expression in ontogenesis is determined by programmed spe-cies-specific activations of retroelements in successive cell divisions. Evolutionary selection of this genome control mechanism is aimed at achieving a mature state, after which unprogrammed activation of retroelements occurs, which expression products stimulate interferon response, aseptic inflammation and aging-associated diseases development, such as atherosclerosis. Interferon in atherosclerosis stimulates pro-inflammatory macrophage phenotype, which con-tributes to pathological immune response, foam cell formation and atherosclerosis progression. Activation of retroele-ments occurs under the influence of viral infections, which role in atherosclerosis development has been proven, which confirms my hypothesis. Dysfunctional foam macrophages produce HERV-K102, which stimulates innate immunity, HERV-K HML2 expression correlates with macrophage immune activation and interferon response. Data were obtained on association with atherosclerosis of microRNAs derived from retroelements, which are involved in the disease path-ogenesis due to their influence on cholesterol metabolism (miR-498, -520d), immune processes (miR-1257, -28, -2909), activation of DNMT1 (miR-1264) and EZH2 (miR-630), gene expression in endothelial cells (10 specific miRNAs), vascular smooth muscle cells (14 specific miRNAs) and macrophages (miR-320b, -326, -378, -384), contributing to pathological phenotype of these cells. In atherosclerosis microRNAs derived from retroelements interact with circular RNAs (miR-495, -576, -579, -630, -633, -637, -942) and long non-coding RNAs (miR-326, -4731, -495, 616, -641, -664a) the key sources of which are retroelements. Role of ANRIL, NEAT1, PAPIA, MAARS, VINAS, H19, AK136714, MIAT, and interaction of Alu elements with ANRIL and NEAT1, identified in atherosclerosis development. The data obtained can become the basis for targeted effect on retroelements activation in atherosclerosis using mi-croRNAs.
Double Asymptotic Scaling '96
Creators: name: Forte, Stefano
name: Ball, Richard D.
Publisher: name: arXiv
Year: 1996
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We review recent HERA data on the structure function F_2 at small x and large Q^2. We show that the salient features of the data are revealed by comparing them to the double asymptotic scaling behaviour which F_2 is predicted to satisfy in perturbative QCD.
description: 5 pages, LaTeX with espcrc2.sty (included), 11 figures included by epsfig
Kinematic Cartography for Locomotion at Low Reynolds Numbers
Creators: name: Hatton, Ross L.
name: Choset, Howie
Publisher: name: Carnegie Mellon University
Year: 2011
Subjects: subject: 80101 Adaptive Agents and Intelligent Robotics
subject: FOS: Computer and information sciences

description: Kinematic motion planning often requires a notion of distance between configurations. Euclidean distances on a parameter space are easy to compute, but can drastically distort the effort required to change configuration. Here, we present a framework for characterizing this distortion, based on principles adopted from the cartographic community, and a method for transforming configuration coordinates to better represent actuation costs. As a demonstration of this approach, we derive a true configuration distance metric for an important class of locomoting systems: low Reynolds number swimmers. Applying our cartographic coordinate transformation to these systems both provides intuition for previous numerical results, and allows direct geometric comparison between systems with heterogeneous morphology.
Extracts of Daedaleopsis Confragosa F-1368 Inhibit In Vitro and In Vivo the Proliferation of Human Cancer Cells
Creators: name: O.I. Solovieva
name: I.A. Razumov
name: T.V. Teplyakova
name: E.L. Zavjalov
Publisher: name: Opera Medica et Physiologica
Year: 2024
Subjects: antitumor activity
anticancer activity
Daedaleopsis confragosa
F-1368
mycotherapy
U-87 MG
glioblastoma.

description: The aim of this study was to evaluate the effects of two variants of the Daedaleopsis confragosa fungus extract, F-1368 strain, differing in polysaccharide concentration, on five human cancer cell lines (U-87 MG, C-33 A, SK-Mel-28, MDA-MB-231, SW620) in vitro. Standard cytotoxicity assessment methods, including MTT-assay and clonogenic assay, were employed. Additionally, an experiment was conducted on laboratory SCID mice with heterotopic xenografts of human glioblastoma U-87 MG, where the test preparations were administered subcutaneously into the tumor area. Tumor sizes were measured using a caliper, and upon euthanasia, xenografts were histologically examined with hematoxylin-eosin staining under a light microscope. Results from MTT and clonogenic assays demonstrated that F-1368 extracts reduced the viability, mitochondrial function, and proliferative activity of tumor cells in vitro. However, a threefold increase in polysaccharide concentration in one of the extracts did not significantly enhance its cytotoxicity against tumor cells in vitro. Furthermore, one extract was tested on U-87 MG cell xenografts, revealing a reduction in tumor growth in SCID mice. The maximum tumor growth inhibition index for U-87 MG cells reached 50.7% at 21 days post-commencement of extract injections. These findings suggest that the D. confragosa F-1368 strain holds promise for investigating both in vitro and in vivo models of antitumor activity and identifying potential bioactive molecules or compounds.
title: La fille séquestrée
title: Lo han-nuu ma mi hanminu
titleType: AlternativeTitle
Creators: name: Leguy, Cécile
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: subject: Boomu
subject: bmq

description: Chanté, Accompagnement : musical à la harpe-luth à 8 cordes (’uanni) avec un accompagnateur qui frappe sur la caisse de résonnance de l’instrument, mais ne dit rien. Le conteur alterne des passages chantés et des passages dits, mais toujours accompagnés de la harpe-luth et du rythme frappé sur la caisse de l’instrument
description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
Recueil des édits, déclarations, lettres patentes, arrêts et règlements du roi registrés en la Cour du Parlement de Normandie, depuis l’année 1643 jusqu’en 1683, Rouen, Lallemand, 1774
Creators: name: N.R.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2017

description: Source: Bibliothèque universitaire du Tertiaire de Rouen, Faculté de droit.BB3274-1
description: Relation: vignette : https://www.nakala.fr/data/11280/b7fe69a6
Iron Gradients in Cooling Flow Galaxies and Groups
Creators: name: Buote, David A.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Previous studies of the Fe abundances in the hot gas of galaxies and groups have reported conflicting results with most studies finding very sub-solar Fe abundances that disagree with standard theory. To investigate the possible role of Fe abundance gradients on these measurements we present deprojection analysis of the ROSAT PSPC data of 10 of the brightest cooling flow galaxies and groups. The PSPC allows for spatially resolved spectral analysis on a half-arcminute scale, and interesting constraints on both the temperatures and Fe abundances are possible because the ~1 keV temperatures of these systems are well matched to the bandpass of the PSPC. In 9 out of 10 systems we find clear evidence that the Fe abundance decreases with increasing radius: Z_Fe ~1 solar - (several) solar within the central radial bin (r < ~10 kpc) which decreases to Z_Fe ~0.5 solar at the largest radii examined (r ~50-100 kpc). The Fe abundances (and temperatures) are consistent with the average values for these systems that we obtained in our previous analyses of the ASCA data using multitemperature models which confirms that previous inferences of very sub-solar Fe abundances from ASCA arise from the incorrect assumption of isothermal gas and not the presence of Fe abundance gradients. We discuss why this ``Fe Bias'' affects much more seriously the measurements of Z_Fe from ASCA data than from ROSAT data. We show that the Fe abundance profiles for these galaxies and groups are consistent with a gas-dynamical model where the gas is enriched by stellar ejecta and supernovae in the ``solar supernova proportion'', the stars formed with a Galactic IMF, and the gas is diluted by mixing with primordial gas at large radii.
description: 16 pages (7 figures), Accepted for publication in ApJ. Added a new section which discusses the relative importance of the Fe Bias and Fe gradients. Also included are results from a new gas-dynamical metal enrichment model
Gene Therapy Using Plasmid DNA Encoding Bone Morphogenetic Protein 2 and Vascular Endothelial Growth Factor 164 Genes for the Treatment of Equine Proximal Suspensory Desmitis: Case Reports
Creators: name: M. Kovac
name: I.V. Berestov
name: A.M. Aimaletdinov
name: C.S. Rutland
name: A.A. Rizvanov
name: E.Yu. Zakirova
Publisher: name: Opera Medica et Physiologica
Year: 2024
Subjects: proximal suspensory desmitis
plasmid DNA
bone morphogenetic protein 2
vascular endothelial growth factor.

description: Injury to the proximal part of the equine suspensory ligament (SL), called proximal suspensory desmitis (PSD), commonly causes lameness in horses. PSD is extremely difficult to manage and treat, with present methods often unable to achieve full recovery, especially in chronic cases. The present study was the first to use gene therapy to restore moderate and severe injuries of the proximal suspensory ligament in horses. Plasmid DNA encoding species specific bone morphogenetic protein 2 (bmp2) and vascular endothelial growth factor (vegf164) was injected into the site of proximal suspensory ligament injury, followed by box rest and a controlled exercise program. Clinical observations and ultrasound imaging were used to evaluate effectiveness over a period of 12 months. No negative side effects were observed. Clinical improvements were observed, especially in the forelimb affected horses, by day 30. In horses with chronic hindlimb PSD, few clinical improvements were reported. Echogenicity and the fiber alignment scoring improved but no concomitant changes to cross section area, dorsopalmar thickness or lateromedial width of the proximal suspensory ligament were observed. The transfer of bmp2 and vegf164 genes into the equine PSL exhibited beneficial effects in horses with acute or subacute forms of lesions, primarily in the forelimb.
K-groups : tractable group detection on large link data sets
Creators: name: Kubica, Jeremy
name: Moore, Andrew W.
name: Schneider, Jeff
Publisher: name: Carnegie Mellon University
Year: 2003
Subjects: subject: 80101 Adaptive Agents and Intelligent Robotics
subject: FOS: Computer and information sciences

description: Abstract: "Discovering underlying structure from co-occurrence data is an important task in many fields, including: insurance, intelligence, criminal investigation, epidemiology, human resources, and marketing. For example a store may wish to identify underlying sets of items purchased together or a human resources department may wish to identify groups of employees that collaborate with each other. Previously Kubica et. al. presented the group detection algorithm (GDA) -- an algorithm for finding underlying groupings of entities from co-occurrence data. This algorithm is based on a probabilistic generative model and produces coherent groups that are consistent with prior knowledge. Unfortunately, the optimization used in GDA is slow, making it potentially infeasible [sic] for many real world data sets. For example, in the co-publication domain the MEDLINE database of medical publications alone contains over 2 million papers published within just a 5 year period, 1995-1999 [14]. To this end, we present k-groups -- an algorithm that uses an approach similar to that of k-means (hard clustering and localized updates) to significantly accelerate the discovery of the underlying groups while retaining GDA's probabilistic model. In addition, we show that k-groups is guaranteed to converge to a local minimum. We also compare the performance of GDA and k-groups on several real world and artificial data sets, showing the k-groups' sacrifice in solution quality is significantly offset by its increase in speed. This trade-off makes group detection tractable on significantly larger data sets."
Subspace Preserving Quantum Convolutional Neural Network Architectures
Creators: name: Monbroussou, Léo
name: Landman, Jonas
name: Wang, Letao
name: Grilo, Alex B.
name: Kashefi, Elham
Publisher: name: arXiv
Year: 2024
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Subspace preserving quantum circuits are a class of quantum algorithms that, relying on some symmetries in the computation, can offer theoretical guarantees for their training. Those algorithms have gained extensive interest as they can offer polynomial speed-up and can be used to mimic classical machine learning algorithms. In this work, we propose a novel convolutional neural network architecture model based on Hamming weight preserving quantum circuits. In particular, we introduce convolutional layers, and measurement based pooling layers that preserve the symmetries of the quantum states while realizing non-linearity using gates that are not subspace preserving. Our proposal offers significant polynomial running time advantages over classical deep-learning architecture. We provide an open source simulation library for Hamming weight preserving quantum circuits that can simulate our techniques more efficiently with GPU-oriented libraries. Using this code, we provide examples of architectures that highlight great performances on complex image classification tasks with a limited number of qubits, and with fewer parameters than classical deep-learning architectures.
CREEP MODELLING FOR REFRACTORY MATERIALS USED IN FURNACE LININGS
Creators: name: SOARES Thais
name: AZENHA Miguel
name: LOURENCO Paulo
Publisher: name: Zenodo
Year: 2019
Subjects: Creep
Mechanical Properties
Elevated loads
High Temperature
Refractories

description: Creep modelling for refractory materiaLs used in furnace linings
Macrolide resistance of H.pylori due to ermB gene during H. pylori infection in real practice
Creators: name: K.M. Perfilova
name: T.Yu. Butina
name: N.V. Neumoina
name: I.V. Shutova
name: I.A. Kuznetsova
name: T.A. Troshina
name: T.V. Shmakova
name: S.N. Levina
Publisher: name: Opera Medica et Physiologica
Year: 2024
Subjects: Helicobacter pylori
macrolide resistance
ulcer disease
clarithromycin
eradication

description: The aim was to study macrolide resistance of erm B-positive H.pylori in patients with newly diagnosed and recurrent helicobacteriosis in Nizhny Novgorod. Materials and methods: PCR detection of H.pylori DNA in gastric juice and biotopes of the mucous membrane of the gastric antrum was performed in 3450 patients with gastroenterological diseases. To identify the ermB gene associated with macrolide resistance, domestic commercial PCR test systems were used. Results: from 2005 to 2023 there was a progressive reduction in visits for gastric and duodenal ulcers. The dynamics of primary and secondary genetic H.pylori macrolide resistance increased continuously from 2011 to 2014 and stabilized thereafter. From 2014 to 2023, the proportion of patients with ermB gene positive H.pylori infection increased approximately 2-fold (to 17.0% in 2018). In patients with a history of eradication therapy, the minimum detection rate of the ermB gene was established in 2011. Since 2012, there has been an increasing detection rate of secondary H.pylori macrolide resistance to 35.4% in 2022. Conclusions: during the observation period, a progressive reduction in the proportion of patients with gastric and duodenal ulcers among patients with gastroenterological diseases was revealed. The study of primary and secondary H.pylori macrolide resistance showed an increase in the detection rate of resistant isolates in Nizhny Novgorod. The study of genetic H.pylori macrolide resistance is necessary when reidentifying in patients with a history of eradication therapy and in patients who took clarithromycin for other reasons for the optimal selection of drugs included in the re-treatment regimen of infection.
Kernel Conjugate Gradient for Fast Kernel Machines
Creators: name: Ratliff, Nathan D.
name: J. Andrew  Bagnell
Publisher: name: Carnegie Mellon University
Year: 2007
Subjects: subject: 80101 Adaptive Agents and Intelligent Robotics
subject: FOS: Computer and information sciences

description: We propose a novel variant of the conjugate gradi- ent algorithm, Kernel Conjugate Gradient (KCG), designed to speed up learning for kernel machines with differentiable loss functions. This approach leads to a better conditioned optimization problem during learning. We establish an upper bound on the number of iterations for KCG that indicates it should require less than the square root of the number of iterations that standard conjugate gradient requires. In practice, for various differentiable ker- nel learning problems, we ﬁnd KCG consistently, and signiﬁcantly, outperforms existing techniques. The algorithm is simple to implement, requires no more computation per iteration than standard ap- proaches, and is well motivated by Reproducing Kernel Hilbert Space (RKHS) theory. We further show that data-structure techniques recently used to speed up kernel machine approaches are well matched to the algorithm by reducing the dominant costs of training: function evaluation and RKHS in- ner product computation.
Supersymmetry and Identical Bands
Creators: name: von Brentano, P.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Supersymmetry as applied to identical bands is discussed. A review of the work of the Koeln-Dubna group on this topic is given and examples in 171,172Yb, 173,174Hf, and 195,194Pt are discussed. The role of pseudo-spin in the supersymmetry is investigated. A recent precision lifetime measurement for identical bands in 171,172Yb is discussed.
description: 14 pages, 5 figures, Erice conference 2003
Late Effects of Subchronic Cadmium Exposure on Metallothionein Gene Expression in Rat Kidneys
Creators: name: Ya.V. Valova
name: A.A. Gisatullina
name: D.A. Smolyankin
name: E.N. Usmanova
name: A.S. Fazlyeva
name: G.F. Mukhammadiva
name: D.O. Karimov
name: N.Yu. Khusnutdinova
name: E.F. Repina
Publisher: name: Opera Medica et Physiologica
Year: 2024
Subjects: heavy metals
subchronic cadmium intoxication
cadmium
metallothioneins
renal toxicity

description: Heavy metals, due to their ability to bioaccumulate and are highly toxic even in low concentrations, are the most dangerous environmental pollutants, especially in industrialized countries. The purpose of the study was to evaluate the degree of cadmium accumulation, as well as the expression of the Mt1a and Mt2a genes, in the kidneys of rats using two experimental models of subchronic intoxication with cadmium chloride. A total of 80 adult white outbred rats of both sexes were equally distributed into four groups: a control group (negative control), group 1 (0.001 mg/kg/day CdCl2), group 2 (0.01 mg/kg/day CdCl2), 3rd group (0.1 mg/kg/day CdCl2). After three months of exposure, 10 animals (5 males and 5 females) were randomly selected from each group and euthanized, followed by kidney samples for cadmium analysis and gene expression assessment. The remaining animals (n = 40) were left for an additional 30 days without treatment, before being sacrificed to collect tissue. The results showed that 1 month after cadmium withdrawal, the processes of redistribution of the metal in the body are still ongoing, which is expressed in a greater accumulation of cadmium in the kidneys. We also recorded an increase in the Mt1a gene expression and a decrease in the Mt2a gene expression in the kidneys of animals that went through the remission stage compared to animals without it. These data suggest that even after Cd withdrawal, there may be long-term negative effects on the kidneys.
'Abram the Warlord' , in The Visual Commentary Of Scripture
Creators: name: Vescovi, Michele
Publisher: name: University of Lincoln
Year: 2024
Subjects: V641 - The Bible & Christian texts
V100 - History by period
V300 - History by topic

description: Michele Luigi Vescovi. 2018. 'Abram the Warlord' , in The Visual Commentary Of Scripture ed. by Ben Quash. (London: The Visual Commentary on Scripture Foundation). [Accessed 21.2.2024]

https://thevcs.org/abram-warlord
$π\to lνγ$ Form Factors at Two-loop
Creators: name: Bijnens, J.
name: Talavera, P.
Publisher: name: arXiv
Year: 1996
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Within Chiral Perturbation Theory (CHPT) we compute the form factors A, V and $γ= A/V$ in the $π\to νl γ$ decay to $O(p^6)$. A and $γ$ obtain corrections of order 25%.
description: Added cut-off dependence discusion, misprints corrected
Crossing Boundaries. Understanding complex scribal practices in Ancient Egypt
Creators: name: Gabler, Kathrin
name: Greco, Christian
name: Loprieno, Antonio
name: Müller, Matthias
name: Polis, Stéphane
name: Sojic, Nathalie
name: Töpfer, Susanne
name: Unter, Stephan
Publisher: name: Zenodo
Year: 2019
Subjects: papyrus
hieratic
Egypt
Deir el-Medina
Machine learning
scribal practices

description: Crossing the epistemological and methodological boundaries between traditional disciplines in Egyptology and beyond, the present project sets out to understand the life of a particular category of complex documents: the ‘heterogeneous’ papyri which bear several texts belonging to various genres (such as, for instance, accounts, poems, hymns and letters). They are of primary importance for the study of the wide competence and the performance of ancient scribes at work. In this project, we target the rich papyrological material that stems from the village of Deir el-Medina, which housed the families of the workmen who built the royal tombs in the Valley of the Kings during the New Kingdom (c. 1350–1000 BCE). This highly literate community produced an unparalleled quantity of texts and inscriptions. Building on existing collaborations between the partners (the university of Basel, the university of Liège, and the Museo Egizio of Turin), the five main goals of our research project are (1) to document the fragments of heterogeneous papyri in the Turin collection; (2) to reconstruct the original documents digitally; (3) to study the variety of texts attested on each papyrus, to assess the numbers of scribes (hands), and ultimately to suggest individual scenarios and generalisations concerning the history of these documents; (4) to enrich the results with data coming from other ancient Egyptian archives from Deir el- Medina; and (5) to broaden the perspective by comparing, both quantitatively and qualitatively, the data from Deir el-Medina with complex scribal practices of other periods and places in ancient Egypt.
title: L’homme prétentieux et ses quatre fils
title: Lo ba-nuu ma mi za nii-na
titleType: AlternativeTitle
Creators: name: Leguy, Cécile
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: subject: Boomu
subject: bmq

description: Accompagnement : musical à la harpe-luth à huit cordes (’uanni) avec un accompagnateur qui frappe sur la caisse de résonnance de l’instrument. Le conteur alterne des passages chantés et des passages dits, mais toujours accompagnés de la harpe-luth et du rythme frappé sur la caisse de l’instrument.
description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
title: L’orpheline
title: Lo himizo
titleType: AlternativeTitle
Creators: name: Leguy, Cécile
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: subject: Boomu
subject: bmq

description: Chanté, Accompagnement : musical à la harpe-luth à 8 cordes (’uanni) avec un accompagnateur qui frappe sur la caisse de résonnance de l’instrument, mais ne dit rien. Le conteur alterne des passages chantés et des passages dits, mais toujours accompagnés de la harpe-luth et du rythme frappé sur la caisse de l’instrument.
description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
title: ADCO, Cartulaire de Cîteaux pour les possessions de Tontenant (c. 1504), Cart. 184 (11 H 987), 105 folios, f. 0014
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2015
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Cartulaire de Cîteaux pour les possessions de Tontenant (c. 1504), Archives départementales de la Côte-d'Or, Cart. 184 (11 H 987), 105 folios, f. 0014, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les possessions de Tontenant (c. 1504), Archives départementales de la Côte-d'Or, Cart. 184 (11 H 987), 105 folios, f. 0014, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
MicroRNA miR-152 Methylation in Patients With Ovarian Cancer: Prognostic Potential Analysis
Creators: name: Yu.Yu. Fedorova
name: A.V. Sagitova
name: E.T. Mingazheva
name: R.R. Faishanova
name: I.R. Zagitov
name: E.A. Andreeva
name: A.Kh. Nurgalieva
name: E.K. Khusnutdinova
name: M. Darvish
name: D.S. Prokofyeva
Publisher: name: Opera Medica et Physiologica
Year: 2024
Subjects: ovarian cancer
microRNA
methylation
miR-152
metastasis.

description: MicroRNAs play a crucial role in the regulation of biological processes variety associated with neoplasm development and progression, such as cell proliferation and differentiation, apoptosis, angiogenesis, inflammation, migration, invasion and metastasis, epithelial-mesenchymal transition and others. The purpose of this work was to investigate the DNA methylation level of miR-152 in 25 paired tissue samples from patients with an established diagnosis of ovarian cancer and various histological and clinical characteristics by the MS-HRM method. Our results indicate a higher frequency of the miR-152 methylation in ovarian tumor tissues (51.5% ± 5.4) compared to normal tissues (43.9% ± 7.2), however, the differences did not reach the statistical level significance, p = 0.5. There was no relationship between the metastatic process in the tumor depending on the level of methylation (46.5% ± 11.9 in patients with metastases vs 45.2% ± 7.8 in cases without metastases). One patient with the highest methylation level of all samples researched – 89.91%, despite a good response to primary therapy, had a relapse of the disease after 7 years. In addition, there is a tendency for a lower level of miR-152 methylation in patients with a complete response to therapy, in contrast to women with a partial response or the tumor process stabilization. Thus, our research provides evidence in favor of the suppressor function of the miR-152 in tumor, and its possible role in sensitivity to polychemotherapy, however, the results did not reach a statistical level of significance and additional studies on larger material are required.
Nonlinear mechanics of thin frames
Creators: name: Moshe, Michael
name: Esposito, Edward
name: Shankar, Suraj
name: Bircan, Baris
name: Cohen, Itai
name: Nelson, David R.
name: Bowick, Mark J.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: The dramatic effect kirigami, such as hole cutting, has on the elastic properties of thin sheets invites a study of the mechanics of thin elastic frames under an external load. Such frames can be thought of as modular elements needed to build any kirigami pattern. Here we develop the technique of elastic charges to address a variety of elastic problems involving thin sheets with perforations, focusing on frames with sharp corners. We find that holes generate elastic defects (partial disclinations) which act as sources of geometric incompatibility. Numerical and analytic studies are made of three different aspects of loaded frames - the deformed configuration itself, the effective mechanical properties in the form of force-extension curves and the buckling transition triggered by defects. This allows us to understand generic kirigami mechanics in terms of a set of force-dependent elastic charges with long-range interactions.
description: 13 pages, 13 figures
Kernel Conjugate Gradient
Creators: name: Ratliff, Nathan
name: J. Andrew  Bagnell
Publisher: name: Carnegie Mellon University
Year: 2005
Subjects: subject: 80101 Adaptive Agents and Intelligent Robotics
subject: FOS: Computer and information sciences

description: We propose a novel variant of conjugate gradient based on the Reproducing Kernel Hilbert Space (RKHS) inner product. An analysis of the algorithm suggests it enjoys better performance properties than standard iterative methods when applied to learning kernel machines. Experimental results for both classiﬁcation and regression bear out the theoretical implications. We further address the dominant cost of the algorithm by reducing the complexity of RKHS function evaluations and inner products through the use of space-partitioning tree data-structures.
ROSAT Evidence for Intrinsic Oxygen Absorption in Cooling Flow Galaxies and Groups
Creators: name: Buote, David A.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Using spatially resolved, deprojected ROSAT PSPC spectra of 10 of the brightest cooling flow galaxies and groups with low Galactic column densities we have detected intrinsic absorption over energies ~0.4-0.8 keV in half of the sample. Since no intrinsic absorption is indicated for energies below ~0.4 keV, the most reasonable model for the absorber is collisionally ionized gas at temperatures T=10^{5-6} K with most of the absorption arising from ionized states of oxygen but with a significant contribution from carbon and nitrogen. The soft X-ray emission of this warm gas can explain the sub-Galactic column densities of cold gas inferred within the central regions of most of the systems. Attributing the absorption to ionized gas reconciles the large columns of cold H and He inferred from EINSTEIN and ASCA with the lack of such columns inferred from ROSAT. Within the central ~10-20 kpc, where the constraints are most secure, the estimated mass of the ionized absorber is consistent with most (perhaps all) of the matter deposited by a cooling flow over the lifetime of the flow. Since the warm absorber produces no significant H or He absorption the large absorber masses are consistent with the negligible atomic and molecular H inferred from HI and CO observations of cooling flows. It is also found that if T > ~2x10^5 K then the optical and UV emission implied by the warm gas does not violate published constraints. Finally, we discuss how the prediction of warm ionized gas as the product of mass drop-out in these and other cooling flows can be verified with new CHANDRA and XMM observations. (Abridged)
description: 17 pages (5 figures), Accepted for publication in ApJ, expanded discussion of multiphase spectral models, theoretical implications of warm gas in cooling flows, and the statistical significance of the oxygen absorption
Possible Etiological Role of IL-10, IL-17 Levels, CD4+ and CD68 in the Pathogenesis of Herniated Disc in Iraqi Patients
Creators: name: D.M. Al-Muathen
name: S.A.H. Al-Sharqi
name: S.A. Brakhas
name: A.A. Taha
Publisher: name: Opera Medica et Physiologica
Year: 2024
Subjects: herniated disc
cytokines
immunohistochemical analysis
CD4+
CD68

description: Herniated (prolapsed) discs HD is a multifactor disease that afflicts around 9% of the global population and occurs when the nucleus pulposus NP bulges and pushes on the ruptured annulus fibrosus AF, releasing substances that may irritate the surrounding nerves and cause inflammation that leads to extensive histopathological and immunological changes. The aim of this study is to demonstrate the etiological role of IL-10, IL-17 levels, CD4+, and CD68 in the pathogenesis of herniated disc in Iraqi patients. The immunohistochemical analysis was performed on 30 excised HD specimens taken during endoscopic discectomy, and stored in the fixative solution (formalin 10%). Cytokines (IL-10 and IL-17) were measured by using their Enzyme-Linked Immunosorbent Assay ELISA kits, in sera of 40 patients who were diagnosed with HDs as a case group, in addition to 20 healthy as a control group. The results revealed that the CD4+ expression was negative in 70% of the HD samples, while only 8 HD samples were negative for CD68 expression. On the other hand, results of ELISA analysis recorded high levels of IL-10 with low levels of IL-17 in HD patients sera compared with control sera. According to the above it can concluded that immunohistochemical analysis of HD tissues showed infiltration of CD4+ and CD68. Also compared to controls high levels of IL-10 in HD samples combined with low levels of IL-17.
Design principles for data quality tools
Creators: name: Altendeitering, Marcel
Publisher: name: TU Dortmund
Year: 2023
Subjects: subject: Data quality
subject: Data quality tools
subject: Data management
subject: Data engineering
subject: Design principles
subject: Design science
subject: 004
subject: Datenqualität
subject: Datenmanagement
subject: Designwissenschaft

description: Data quality is an essential aspect of organizational data management and can facilitate accurate decision-making and building competitive advantages. Nu-merous data quality tools aim to support data quality work by offering automa-tion for different activities, such as data profiling or validation. However, de-spite a long history of tools and research, a lack of data quality remains an issue for many organizations. Data quality tools face changes in the organizational (e.g., evolving data architectures) and technical (e.g., big data) environment. Established tools cannot fully comprehend these changes, and limited prescrip-tive design knowledge on creating adequate tools is available. In this cumula-tive dissertation, we summarize the findings of nine individual studies on the objectives and design of data quality tools. Most importantly, we conducted four case studies on implementing data quality tools in real-world scenarios. In each case, we designed and implemented a separate data quality tool and abstracted the essential design elements. A subsequent cross-case analysis helped us accu-mulate the available design knowledge, resulting in the proposal of 13 general-ized design principles. With the proposal of empirically grounded design knowledge, the dissertation contributes to the managerial and scientific commu-nities. Managers can use our results to create customized data quality tools and assess offerings at the market. Scientifically, we address the lack of prescriptive design knowledge for data quality tools and offer many opportunities to extend our research in multiple directions. The continuous work on data quality tools will help them become more successful in ensuring data fulfills high-quality standards for the benefit of businesses and society.
Evaluating the Constructionist Approach in Entrepreneurship Education
Creators: name: Löbler, H.
name: Maier, M.
name: Markgraf, D.
Publisher: name: The School of Education and Communities, University of East London
Year: 2021

description: In trying to apply a ‘new’ approach in education, we used Löbler’s (2006) ten principles for entrepreneurship education. After two years of fine-tuning and improving the programme, we were interested in evaluating it and comparing it to other learning approaches mentioned in the literature and used in practice. The goal is twofold: Firstly, we wanted to find out whether the ‘constructionist’ learning environment does support autonomy in thinking and doing. Secondly, we were interested in figuring out if the students learned more and kept working harder while being more motivated on their projects compared to the other learning environments. The results show that this kind of ‘constructionist’ coursework is superior with regard to many criteria and preferred by the students compared to the other learning approaches. The students also reported that they worked with much more enthusiasm and delight. Our analysis shows that the ten principles are working in practice and could be an advantage for students and teachers.
The Impact of Global DNA Methylation and Hypoxia-Inducible Factor 1 Alpha Levels in the Progression of Breast Cancer
Creators: name: B.R. Sahar
name: R.M.Kh. Al-Jumaily
Publisher: name: Opera Medica et Physiologica
Year: 2024
Subjects: DNA methylation
HIF-1α
breast cancer
benign breast tumor

description: Breast cancer (BC) is one of the most common causes of death among women in the world. This study investigated the role of global DNA methylation (5mC) and hypoxia-inducible factor 1 alpha (HIF-1α) levels in BC disease progression. Blood samples were collected from 40 patients with benign breast tumors, 40 patients with malig-nant breast tumors, and 40 healthy subjects. Patients with malignant breast tumors were divided into two groups: women in stage II (low-level), and patients in stages III and IV (high-level). Genomic DNA was isolated from whole blood samples from the subjects and used for global DNA methylation. Furthermore, the levels of HIF-1α expression were measured. The results showed that the levels of 5mC in patients with BC and benign breast tumors were considerably lower (0.538 ± 0.03 and 0.432 ± 0.04%, respectively), compared to the control (0.619 ± 0.05%). Furthermore, there was a significant (p ≤ 0.05) decrease in levels of 5mC in BC patients at stages III and IV compared to control. However, there were no significant differences between low-level and high-level stages. The HIF-1α levels of patients in both the benign breast tumors and BC were insignificant (923.35 ± 72.42 and 1386.03 ± 102.01pg/ml, respectively), compared to the control (825.5 ± 62.36 pg/ml). Although, BC patients at low levels showed no significant difference in HIF-1α levels compared with patients at high levels. The findings indicated that variations in 5mC levels across different stages and types of breast tumors may serve as a prognostic indicator for the development of BC and also implicated HIF-1α in the development of BC.
Kalman filter-based algorithms for estimating depth from image sequences
Creators: name: Matthies, Larry
name: Szeliski
name: Kanade, Takeo
Publisher: name: Carnegie Mellon University
Year: 1988
Subjects: subject: 80101 Adaptive Agents and Intelligent Robotics
subject: FOS: Computer and information sciences

description: Robotics Institute
title: Promoting and financing industrial diversification in resource-dependent developing countries
Creators: name: Altowaim, Sultan
Publisher: name: University of Glasgow
Year: 2018
Subjects: subject: Economic development, Industrial policy, financing economic development, economic diversification.

description: This thesis studies the promotion and financing of industrial diversification in natural resource-dependent countries. It tries to contribute to the existing literature by addressing three research questions in three main chapters. Chapter 2 attempts to answer the following question: Does financial development induce the diversification and complexity of exports in natural resource-dependent countries? Financial development and deregulation are standard recommendations in order to achieve greater industrial and economic development in these countries. However, using standard panel data econometrics, this chapter shows that financial development has no positive impact on export diversification or complexity. It argues that a general financial development policy recommendation is not expected to be a key for industrial and export diversification in these countries. This result provides an essential motivation for the following chapters. Chapter 3 looks at the financing of industrial diversification in two specific countries, namely Chile and Malaysia, which were both natural resource-dependent, but managed to successfully diversify their respective economies. The two countries have followed different strategies. In Chile, diversification has been towards niche natural resource-based industries, while in Malaysia the strategy has been to defy comparative advantages, resulting in specialization in sophisticated and high value added products. This chapter examines the role of the state and the financial system in financing the industrial diversification. The main finding is that in both countries the state has always played a key role in directing finance to strategic sectors and in contributing to the emergence of new industrial activities. Diversification in Chile and Malaysia has not occurred through free market operations and liberalized financial systems settings. Chapter 4 concentrates on promoting industrial diversification in oil dependent countries using Saudi Arabia as the case study. It starts by reviewing various strategies of economic diversification in the context of resource-dependent countries. In particular, it reviews the literature on resource-based industrialization (e.g. Perez, 2015), the literature on the Growth Identification and Facilitation Framework (i.e. Lin 2011) and the literature on the product space theory (i.e. Hidalgo and Hausmann 2009). This chapter, then, uses these frameworks to suggest possible diversification strategies in Saudi Arabia and to assess the government’s recently promoted diversification plan (Vision 2030). Furthermore, the potential role of the Saudi financial system is fully examined.
Development of a tool for Bayesian data analysis and its application in Monte Carlo tuning
Creators: name: La Cagnina, Salvatore
Publisher: name: TU Dortmund
Year: 2023
Subjects: subject: Bayesian analysis
subject: Monte Carlo tuning
subject: Data analysis
subject: Statistical methods
subject: Particle physics
subject: Numerical methods
subject: 530
subject: Bayes-Verfahren
subject: Monte-Carlo-Simulation
subject: Elementarteilchenphysik

description: In this thesis, a novel approach to Monte Carlo event generator tuning, grounded in Bayesian reasoning, is presented. The Bayesian Analysis Toolkit (BAT.jl) is introduced as a modern tool for performing Bayesian inference. A numerical test suite that verifies the validity and performance of the BAT.jl package is developed. The test suite is used to evaluate the performance of the Markov chain Monte Carlo (MCMC) sampling algorithms implemented in BAT.jl, utilizing a selection of test functions and different metrics to quantify the quality of the samples. The results show that the MCMC algorithms are able to sample the posterior distributions of the test functions accurately. Utilizing the BAT.jl toolkit, two hadronization models within the Herwig Monte Carlo event generator (MCEG) are successfully tuned to data from the LEP experiments. Several aspects of the tuning procedure are investigated, such as parameter and observable selection and parametrization quality. Samples generated using the tuned parameters, obtained from the global mode of the posterior, are compared to data through a χ2 test. The resulting p-values for the tuned simulations significantly outperform those from the nominal MCEG samples, indicating a successful tune and an improved description of the data. The posterior is also used to present a method for propagating the parameter uncertainties to the realm of the observables, providing a measure for the tuning uncertainty. Studies on the impact of assigning weights to the observables and the impact of correlations between measurements on the tuning are also presented. These show that weights can alter the tuning results, especially in cases with multiple modes in the posterior. However, their influence on the quality of the tune is minimal in this case. The correlation of measurements has less of an impact on the position of the global mode but substantially affects the associated parameter uncertainties estimates. Finally, a comparison of the two tuned hadronization models is presented, which indicates that the Lund string model describes the data slightly better than the cluster hadronization model for this set of observables.
title: L’homme qui voulait prendre la femme de son fils
title: Lo ba-nuu ma mi nii
titleType: AlternativeTitle
Creators: name: Leguy, Cécile
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: subject: Boomu
subject: bmq

description: Chanté, Accompagnement : musical à la harpe-luth à 8 cordes (’uanni) avec un accompagnateur qui frappe sur la caisse de résonnance de l’instrument, mais ne dit rien. Le conteur alterne des passages chantés et des passages dits, mais toujours accompagnés de la harpe-luth et du rythme frappé sur la caisse de l’instrument.
description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
The Role of the Polymorphism rs28362491 of the NFKB1 Gene in the Gastric Cancer Development
Creators: name: A.Kh. Nurgalieva
name: S.A. Mustafin
name: S.G. Petrova
name: N.V. Ekomasova
name: D.D. Sakaeva
name: Y.Y. Fedorova
name: G.R. Abdeeva
name: M.A. Dzhaubermezov
name: R.R. Abdeev
name: R.R. Rakhimov
name: E.K. Khusnutdinova
name: D.S. Prokofyeva
Publisher: name: Opera Medica et Physiologica
Year: 2024
Subjects: polymorphism
association
NFKB1 gene
gastric cancer

description: Gastric cancer (GC) is one of the most common cancer types in the world with a high mortality rate. It is assumed that polymorphisms of the NFKB1 gene that disrupt its expression predispose to the development of epithelial cancer, including GC. The aim of this study is to explore the association of polymorphism rs28362491 of NFKB1 gene with the risk of GC development for individuals from the Volga-Ural region of Russia. The samples for the study were the DNA of 374 patients with GC and 365 healthy donors of various ethnicities (Russians, Tatars, Bashkirs). It was shown that in all studied groups the most common heterozygous genotype ID of the polymorphic locus rs28362491 of the NFKB1 gene, alleles I and D occur with similar frequencies. Also, it has been established that for Tatars, allele D of the rs28362491 polymorphic locus of the NFKB1 gene is a marker of an increased risk of developing GC, and allele I and genotype II are markers of a reduced risk of developing GC. Meta-analysis showed statistically significant differences in the distribution of allele frequencies of the polymorphic locus rs28362491 of the NFKB1 gene between patients with cancer and controls when combining samples of Tatars and Bashkirs. We hypothesize that polymorphism rs28362491 of the NFKB1 gene may contribute to the genetic structure of susceptibility to GC.