cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Targeting Robo4-Dependent Slit Signaling to Survive the Cytokine Storm in Sepsis and Influenza
Creators: name: London, Jr
Publisher: name: University of Utah
Year: 2014

description: The mature capillary network, comprised of a quiescent endothelial cell monolayer, utilizes tight cell-cell interactions to maintain vascular stability and limit vascular leak. An essential component of these intercellular contacts is the adherens junction protein vascular endothelial cadherin (VE-cadherin). In multiple disease settings such as macular degeneration, sepsis, and pandemic influenza, the endothelium is activated and destabilized by cytokines such as vascular endothelial growth factor (VEGF), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α). While an innate immune response is necessary to combat infection, an exuberant cytokine release can paradoxically injure the host endothelium, resulting in vascular damage, tissue edema, and death. In this dissertation we demonstrate that an endogenous, endothelial-specific Roundabout (Robo), Robo4, maintains vascular stability and quiescence. Administration of Slit, an endogenous activator of Robo receptors, strengthens endothelial barrier function and limits vascular leak in a Robo4-dependent manner. Furthermore, Slit treatment enhanced survival during sepsis and avian flu infection, diseases both characterized by hypercytokinemia. We also discovered that Slit strengthens the vascular barrier by increasing VE-cadherin localization at the cell surface. Slit also increases p120-catenin localization at the cell surface and enhances the interaction of p120-catenin with VE-cadherin, preventing the internalization of VE-cadherin. Furthermore, Robo4 activation leads to the recruitment of a paxillin-GIT1 signaling module that inactivates Arf6. Arf6 plays a known role in regulating endocytic recycling, thus perhaps defining Robo4-dependent Slit signaling as a paxillin-GIT1-Arf6-p120-catenin-VE-cadherin stabilization pathway. Our studies fundamentally demonstrate that by specifically blunting the vascular response to hypercytokinemia, mortality can be reduced during severe experimental infections. Activation of a vascular stabilizing pathway such as Robo4 may therefore provide a platform for treating multiple infectious threats characterized by an exuberant cytokine response.
Genetics of sex chromosomes and sex-linked molecular markers in papaya (Carica papaya L.)
Creators: name: Vashistha, Priyanka
name: Yadav, Anurag
name: Nath Dwivedi, Upendra
name: Yadav, Kusum
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Papaya (Carica papaya L.) is an edible tropical fruit crop which has several medicinal and nutritional benefits. Sex type determination is more complicated in trioecious papaya at early seedling stage. Many hypothesis and research have been done to understand the genetics of sex determination. Various methods based on morphological, cytological traits and isozyme based markers have been utilized for sex identification, but none of these were efficient to solve the problem of sex dentification in papaya at early seedling stage. Hence, sex-linked molecular markers including RAPDs, ISSRs and AFLPs have been developed in papaya and some advanced molecular markers like SSRs and SNPs have been developed in other plant species for sex identification, which indicated that these markers could also be utilized to differentiate male, female and hermaphrodite plants at early seedling stages in papaya.
Sonnenfleckenzeichnung Nr. 22562.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 21.07.1967, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
A new furanochromone from the leaves of Mimosa pigra
Creators: name: Nguyen, Loan Ngoc Phuong
name: Huu, Duc Minh Nguyen
name: Dang, Huu Phuc
name: Huynh, Ngoc Vinh
name: Dang, Phu Hoang
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Plant Biology

description: Phytochemical study on the EtOAc-soluble extract of the leaves of Mimosa pigra led to the isolation of a new furanochromone, 6,8-dihydroxy-2-methyl-9H-furo[3,2-b]chromen-9-one (1), along with four known compounds (2–5). Their structures were elucidated based on the basis of the spectral interpretation. The plausible biosynthesis pathway for the formation of the new furanochromone was proposed. At a concentration of 100 µM, compound 1 showed no cytotoxicity against human MCF-7 breast cancer cell with a cell viability >50%.
Sonnenfleckenzeichnung Nr. 22574.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 03.08.1967, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
The influence of novel orthographic information on second language word learning: the case of native English speakers learning Arabic
Creators: name: Showalter, Catherine E.
Publisher: name: University of Utah
Year: 2012
Subjects: Arabic as a second language
Orthography
Word learning

description: Recent research indicates that knowledge of words' spellings can influence memory of phonological forms of second language (L2) words. For example, L2 learners whose first language uses the Roman alphabet remember newly-learned words more accurately when provided spelled forms in Roman orthography than when spelled forms are unavailable. Research also indicates that learners exposed to novel suprasegmental tone marks are more likely to remember tones associated with novel words and create tone-tone mark correspondences than learners not exposed to tone marks. However, while learners can use familiar letters and novel suprasegmental marks to make inferences about phonological forms, it is unknown whether learners can use entirely unfamiliar orthographic symbols. I therefore asked: Can learners use their knowledge of the alphabetic principle to infer phonological forms of new words when presented an unfamiliar L2 orthography? (Experiment 1). Did learners create graphemephoneme correspondences given orthographic representations? (Experiment 2). Native English speakers (no Arabic experience) were randomly assigned to Orthography or Control word learning groups. Six nonword minimal pairs contrasting Arabic velar-uvular contrasts (i.e., [k] and [q]) were randomly assigned picture "meanings". During a word learning phase, subjects saw pictures and spelled forms (either the word spelled in Arabic script-Orthography condition, or a meaningless sequence of Arabic letters-Control condition), and heard auditory forms. In Experiment 1, subjects determined whether a picture associated with, e.g., [kaʃu], matched an auditory form [qaʃu]. There was a significant effect of item type (p
Anomiopus lacordairei
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Anomiopus
Anomiopus lacordairei

description: Anomiopus lacordairei (Waterhouse, 1891)
Onthocharis lacordairei Waterhouse 1891a: 354 (French Guiana)
Distribution. Suriname: Larsen 2011: 97. French Guiana: Waterhouse 1891a: 354 (as Onthocharis lacordairei); Gillet 1911b: 51 (as Onthocharis lacordairei); Blackwelder 1944: 204 (as Onthocharis lacordairei); Canhedo 2006: 375.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 59, DOI: 10.5281/zenodo.3678492
Optimization and Visualization Tools for Situational Awareness in Highly Renewable Power Systems
Creators: name: Cuffe, Paul
Publisher: name: figshare
Year: 2020
Subjects: subject: 120307 Visual Communication Design (incl. Graphic Design)
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: As presented at 2020 IEEE International Energy Conference (ENERGYCON)

Manuscript and presentation video uploaded here.

Abstract:

This paper proposes new tools for predicting and visualising the plausible near term shifts in branch loading that may arise due to output fluctuations from renewable generators. These tools are proposed to enhance situational awareness for control room operators, by providing early warnings of where bottlenecks may manifest in a transmission system. For predicting plausible branch loading shifts, a linear optimal power flow formulation is presented which uses a novel objective function to characterise the maximum loading a branch could be exposed to in the short term. This analysis therefore identifies which branches could become overloaded due to shifts in output from volatile generators. Equivalently, these branches can be seen as congestion bottlenecks which may cause curtailment of renewable generation. To allow the system operator to maintain awareness of such potentialities, these congestable branches are highlighted on a system diagram which is drawn to explicitly portray the electrical distance between components in the network.
Sonnenfleckenzeichnung Nr. 22466.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 08.04.1967, erstellt von Johann Dürst
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Engraftment of hematopoietic stem cell and progenitor cell populations
Creators: name: Pohlmann, Suzanne Jean
Publisher: name: University of Utah
Year: 2012
Subjects: Hematopoietic Stem Cells

description: Bone marrow transplantation has revolutionized human medicine by extending the life span, and even curing, individuals afflicted with cancer and other pathological hematologic conditions. However, the mechanisms that mediate the engraftment of hematopoietic stem cells (HSCs) after transplantation remain largely obscure. A more comprehensive understanding of the factors that positively and negatively effect engraftment of stem cell and progenitor cell populations is needed to achieve greater success in performing bone marrow and stem cell transplants by preventing the occasional transplant failure. Evaluating the ability of several defined stem cell and progenitor cell populations to contribute to WBC recovery following transplantation into irradiated mice, we found the Rholow subset of stem cells to be solely responsible for bone marrow reconstitution at long periods of time posttransplant. In addition, we identified a lymphoid progenitor cell population that possessed a phenotype very similar to stem cells cells (Sca-1+ c-kit+ Lineageneg Thyneg) and that mediated lymphoid reconstitution of the bone marrow and blood at very early times posttransplant. The results of these studies also demonstrated that the use of different selection protocols for isolating the Thyneg population could drastically diminish the early reconstitutive properties of these cells. Specifically, the c-kit allophycocyanin conjugate derived from the 2B8 clone, but not the c-kit biotin conjugate derived from the ACK4 clone, suppressed the early lymphoid recovery demonstrated by this cell population.   Lastly, we devised a new murine model for performing bone marrow transplants that involved transplanting two bone marrow grafts separated by a time interval of several days. Subsequent serial transplantation of bone marrow from reconstituted recipients resulted in significantly greater peripheral blood reconstitution by the second graft in tertiary recipients. However, this was only found to be true when the second graft was administered to primary recipients 3 or 5 days after the first graft. We subsequently revealed there was a 4-fold increase in HSC numbers in primary recipients that received the second graft after a 5-day delay. This supports the idea that HSCs may lose their self-renewal and proliferative properties following transplantation. Therefore, this modified transplant regime may prove useful in preventing graft failure after very long periods of time posttransplant.
Identification of knowledge gaps in adolescent with sickle cell disease
Creators: name: Hall, Jennifer
Publisher: name: No Publisher Supplied
Year: 2020

description: Purpose of Project: The purpose of this project was to assess the current disease knowledge of adolescents with sickle cell disease (SCD) aged 12-17 years in an outpatient hematology clinic and identify gaps in specific knowledge domains. This information was then used to develop an age-appropriate educational intervention which targets the identified common knowledge gaps. Methodology: Participants completed an online anonymous survey about SCD knowledge which measured knowledge in six domains: genetics, disease pathophysiology, symptoms/management, triggers/prevention, complications, and treatment. The knowledge gaps were identified by the lowest mean scores and an age-appropriate educational intervention was developed to address the domains with the lowest scores. Results: Knowledge gaps were found in the domains of disease complications and treatment with average scores of 49% and 55%, respectively. Education in these domains was provided in the form a storyboard that will be used with adolescents in the transition process.Implications for Practice: The results of this survey were used to guide the development of an educational intervention to address the shortcomings in SCD knowledge with the intent of enhancing the transition process. This project may also encourage other programs to consider ways to evaluate and address the needs of adolescent with SCD in their own practice.
Adequacy of capillary lead specimens
Creators: name: Johnson, Nathan H.
Publisher: name: University of Utah
Year: 2012
Subjects: Toxicity

description: In response to the increased demand for reliable alternatives to venous lead testing, the Centers for Disease Control has called for increased research into using capillary methodologies.  In the past, there have been problems with this procedure, primarily because of external lead contamination falsely elevating values.  A three tiered approach was developed to assess the adequacy of capillary lead specimens.  The first approach involved examination of a large database of capillary and venous samples for obvious differences.  The second, approach involved analysis of elevated lead follow-ups for indications of gross contamination.  The last approach involved experimentation to determine if hand washing eliminates gross contamination.  Obvious differences were found between the venous and capillary databases.  Gross contamination was rare, but the data suggest variables minor contamination.  The analysis of elevated lead follow-ups demonstrated that gross contamination is sometimes present, but more likely to decrease in follow up results is due to day to day fluctuations in lead levels and decreases in minor contamination.  Experimentation demonstrated that hand washings greatly reduces the amount of external lead contamination.  Capillary lead testing should be considered a viable alternative to venous testing, provided that the patient and collector are meticulous in detail.
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 08.04.1967, erstellt vermutlich von Dendis am Skalnate Pleso Observatorium
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage am Skalnate Pleso Observatorium. Es sind zudem statistische Angaben für die Bestimmung der Fleckenrelativzahl notiert. Instrument: unbekannt, Sonnenbild D = 25 cm
Perception Towards E-Payment System : Impact and Considerations
Creators: name: Srivastava, Mukesh
name: Sinha, Dr. Sandhya
Publisher: name: figshare
Year: 2022
Subjects: subject: 150501 Consumer-Oriented Product or Service Development
subject: FOS: Economics and business
subject: 150503 Marketing Management (incl. Strategy and Customer Relations)
subject: 150502 Marketing Communications
subject: 150309 Logistics and Supply Chain Management

description: E-commerce provides the capability of buying and selling products, information and services on the Internet and other online environments. In an e-commerce environment, payments take the form of money exchange in an electronic form, and are therefore called Electronic Payment. E-Payment system is secure there should be no threat to the user credit card number, smart card or other personal detail, payment can be carried out without involvement of third party, It makes E payment at any time through the internet directly to the transfer settlement and form E-business environment. Studied have been carried out on E-Payment system .E-Payment system an integral part of electronic commerce. An efficient payments system reduces the cost of exchanging goods and services, and is indispensable to the functioning of the interbank, money, and capital markets. Questions are related to E-Payment system in which given options are Agree, Disagree, Strongly disagree, Strongly agree, Neutral. After analysis and comparison of various modes of electronic payment systems, it is revealed that it is quite difficult, if not impossible, to suggest that which payment system is best. Some systems are quite similar, and differ only in some minor details. Thus there are number of factors which affect the usage of e-commerce payment systems. Among all these user base is most important success of e-commerce payment systems also depends on consumer preferences, ease of use, cost, industry agreement, authorization, security, authentication, non-refutability, accessibility and reliability and anonymity and public policy.
Sonnenfleckenzeichnung Nr. 22483.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 28.04.1967, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Anomiopus laetus
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Anomiopus
Anomiopus laetus

description: § Anomiopus laetus (Waterhouse, 1891)
Onthocharis laeta Waterhouse 1891a: 351 (Brazil - LECTOTYPE)
Distribution. Brazil (NA): Waterhouse 1891a: 351 (as Onthocharis laeta); Blackwelder 1944: 204 (as Onthocharis laeta); Vaz-de-Mello 2000: 190; Canhedo 2006: 447 (designation LECTOTYPE Onthocharis laeta) (NA). “Amazon Basin”: Gillet 1911b: 51 (as Onthocharis laeta).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 59, DOI: 10.5281/zenodo.3678492
Philip II and the construction of Macedonian state
Creators: name: Phillips, Cynthia Kimball
Publisher: name: University of Utah
Year: 2012
Subjects: Ancient macedonia
Macedonian army
Macedonian monarchy
Macedonian state
Philip II
State construction

description: The accomplishments of Philip II of Macedonia have long been overshadowed by those of his son, Alexander the Great, due to the spectacular nature of Alexander's achievements and to the survival of ancient sources, though written later, that have documented Alexander's reign. Little remains of the histories or writings of Philip's contemporaries, and those that do remain are hostile to Philip and almost exclusively pro-Athenian. Ancient sources focus on Philip's diplomacy, imperialism, and character flaws-all from the view of outsiders watching Philip's actions against their Greek states. These ancient literary sources have necessarily focused the modern discussion of Greece in the 4th century BC on those same subjects and away from a survey of Philip's policies, systems, and successes within Macedonia. This thesis reviews the ancient literary, epigraphic, numismatic, and archaeological evidence in an effort to investigate Philip's initiatives and actions within Macedonia and to suggest the ideology related to these plans and strategies. Based on a review of this evidence, this thesis argues that Philip created a Macedonian state based on traditional Macedonian institutions, as well as new practices, that served Philip's purpose of uniting his disparate territories and peoples into one nation; and that Philip's reformed army provided the mechanism for Philip's achievement of his political, economic, and social goals, and importantly, for defining a national culture.
Guiding principles on the education and practice of theranostics
Creators: name: Pascual, Thomas NB
name: Paez, D
name: Iagaru, A
name: Gnanasegaran, G
name: Lee, Sze
name: Sathekge, M
name: Buatti, JM
name: Giammarile, F
name: Al-Ibraheem, A
name: Pardo, MA
name: Baum, RP
name: De Bari, B
name: Ben-Haim, S
name: Blay, JY
name: Brink, A
name: Estrada-Lobato, E
name: Fanti, S
name: Golubic, AT
name: Hatazawa, J
name: Israel, O
name: Kiess, A
name: Knoll, P
name: Louw, L
name: Mariani, G
name: Mirzaei, S
name: Orellana, P
name: Prior, JO
name: Urbain, JL
name: Vichare, S
name: Vinjamuri, S
name: Virgolini, I
name: Scott, Andrew
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 4003
subject: Biomedical engineering

description: Purpose: The recent development and approval of new diagnostic imaging and therapy approaches in the field of theranostics have revolutionised nuclear medicine practice. To ensure the provision of these new imaging and therapy approaches in a safe and high-quality manner, training of nuclear medicine physicians and qualified specialists is paramount. This is required for trainees who are learning theranostics practice, and for ensuring minimum standards for knowledge and competency in existing practising specialists. Methods: To address the need for a training curriculum in theranostics that would be utilised at a global level, a Consultancy Meeting was held at the IAEA in May 2023, with participation by experts in radiopharmaceutical therapy and theranostics including representatives of major international organisations relevant to theranostics practice. Results: Through extensive discussions and review of existing curriculum and guidelines, a harmonised training program for theranostics was developed, which aims to ensure safe and high quality theranostics practice in all countries. Conclusion: The guiding principles for theranostics training outlined in this paper have immediate relevance for the safe and effective practice of theranostics.
Senegalin, a new phenylpropanoid and other secondary metabolites from the stem bark of Ekebergia senegalensis A. Juss. (Meliaceae)
Creators: name: Kemayou, Guy Paulin M.
name: Happi, Gervais M.
name: Ngandjui, Yvan Anderson T.
name: Tchouankeu, Jean Claude
name: Sewald, Norbert
name: Ali, Muhammad S.
name: Kouam, Simeon F.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified

description: Senegalin (1), a new phenylpropanoid has been isolated from the stem bark of Ekebergia senegalensis A. Juss. along with twelve known secondary metabolites including coumarins 2–5, 4-hydroxy-3,5-methylbenzoic acid (6), pentacyclic triterpenoids 7–9, acyclic triterpenoids 10 and 11 and steroids 12 and 13, respectively. Their structures were elucidated with the help of spectroscopic techniques including 1 D- and 2 D-NMR. The antibacterial activity of the major compounds (2, 9–11) was evaluated on five bacterial strains. However, only compounds 2 and 11 showed a weak inhibition against Bacillus subtilis and Pseudomonas agarici. Furthermore, the chemotaxonomic significance of these compounds has also been elaborated.
Application of genetic algorithms to determine the best combination of main and booster fans
Creators: name: Shriwas, Mahesh Kumar
Publisher: name: University of Utah
Year: 2015
Subjects: Fan
Genetic alogrithms
Mine
Recirculation
Risk
Ventilation

description: One major challenge in mine ventilation is to determine the best combination of main and booster fan pressures to satisfy the airflow requirements and minimize the overall power consumption. This study presents a genetic algorithm-based program to solve mine ventilation network problems. The program, written in C++ language, combines genetic algorithms (GAs, developed by MIT) and a ventilation simulator (xyz.c, developed by MVS Engineering). The program also known as GVENT is used to determine the best combination of main and booster fan pressures for a sample and a coal mine ventilation network. For a sample network, the program generated the power requirement for two alternatives: 1. Single-fan system, 2. Two-fan systems. A comparison of the results shows that the second alternative reduces main fan pressure and leakages and consequently results in net savings of 487 kW (19%). For the coal mine ventilation network, the program generated the power requirements for two alternatives: 1. three surface fan system and 2. three surface and two booster fan system. A comparison of the results shows that the second alternative (three surface and two booster fans) results in a net savings of 209 kW. The results generated by this program were compared with those generated by a ventilation simulator, VnetPC, and found that these were within the 0.5% accuracy. Using this new approach, the results were generated faster and with less human intervention than those generated by the simulator. In addition to the GA-based program, two separate programs were developed to evaluate the network results for flow recirculation. These programs, based on search routines, were used to test the results of the sample network problem described previously. In each case, the outcomes were positive-no recirculation paths were found. The program identified the recirculation paths successfully. In summary, this research study presents a GA-based fan selection program that can be used by mine operators to determine the best combination of fan pressures (surface and underground booster fans) that satisfies the mine flow requirements, reduces leakage, and minimizes the total power consumption.
Xunzi and trust in moral testimony
Creators: name: Liu, Yang
Publisher: name: University of Utah
Year: 2014
Subjects: Moral expertise
Moral testimony
Social institutions
Trust
Xunzi

description: Relying on moral testimony has been widely considered to be problematic in a way that relying on testimony about nonmoral matters is not. One explanation for this difference is the problem associated with identifying trustworthy sources of moral testimony. Moral knowledge involves knowledge of appropriate ends; as such, those who do not have moral expertise have no way of checking on the results of the testimony of purported moral experts in order to verify their expertise. As a result of this problem, the "credentials problem," those who would benefit most from moral testimony (i.e., non-experts) have no way of identifying reliable testifiers. I argue that a view of moral knowledge and cultivation like that found in the Xunzi is a plausible alternative that has advantages over the view that informs the modern discussion of moral testimony. In particular, Xunzi's system of "politically sanctioned moral expertise" provides a way for those without moral expertise to recognize appropriate sources of moral testimony on the basis of their sanctioned authority; trust in the institution which accredits and sanctions moral experts functions as a shortcut to identifying reliable sources of moral testimony. I conclude that, despite the potential problems for such a system, having an institution which accredits moral experts, functioning much like the scientific and medical institutions we already rely on, is better than the alternative of distrusting moral testimony and depending on individual effort to acquire moral understanding or to identify trustworthy sources of moral guidance.
Sonnenfleckenzeichnung Nr. 22467.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 09.04.1967, erstellt von Johann Dürst
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Examining factors influencing how individuals decide whether or not a behavior counts as "having sex"
Creators: name: Sewell, Kelsey K.
Publisher: name: University of Utah
Year: 2013
Subjects: definition
having sex
intimate behaviors
orgasm
sex

description: This study examined how people define having sex as a function of the specific behaviors (e.g., penetrative vs. nonpenetrative acts; whether or not orgasm occurs) and the context in which the behaviors occur (i.e., engaged in by self vs. other). Utilizing a more complex and sensitive research design than in previous studies in this area, 267 men and 367 women rated their degree of confidence that each of 21 physically intimate behaviors (e.g., penile-vaginal intercourse) counted as sex. Separate ratings were made for each behavior when engaged in by (1) the respondent and (2) his/her partner with someone else.Results showed that, for both sexes, some behaviors (e.g., penile vaginal intercourse) were far more confidently rated as having sex than were others (e.g., oralgenital stimulation). Further, both men and women were significantly more certain that a behavior counted as "having sex" when engaged in by their partner (with someone else) than when they engaged in the behavior. Finally, the order in which the two scenarios (i.e., self vs. partner) was presented significantly affected participants' ratings (e.g., partner's behaviors were more confidently rated as "having sex" when these rating were made before rather than after rating one's own behaviors). These findings are discussed in the context of participants' qualitative explanations for their ratings. The methodological and sexual health implications of the results are explored.
Detection of minimal residual disease in breast cancer patients undergoing high-dose chemotherapy and stem cell rescue
Creators: name: Bills, Ada Caroline
Publisher: name: University of Utah
Year: 2012

description: High-dose chemotherapy with autologous stem cell rescue has become a standard treatment modality for women with breast cancer. An important, unresolved issue whether the stem cell product used for transplantation is contaminated with residual tumor cells that are capable of giving rise to disease when reinfused. Detection of residual breast tumor cells in stem cell products is complicated by their low frequency and lack of a suitable assay. The goal of this study was to develop a sensitive assay for detection of rare tumor cells and to determine the significance of tumor cell contamination on clinical outcome. Two assays, immonuhistochemistry (IHC) and flow cytometry (FCM), were developed using antibodies to cytokeratin (CK) proteins in cells of epithelial origin. The patient cohort included 45 stage IV and five stage II/III breast cancer patients, 13 nonepithelial cell cancer patients and three normal stem cell donors. CK-positive cells were detected by both assays in breast cancer patients with a median incidence of 2.17 (IHC) or 1.34 (FCM) per 10 (5) mononuclear cells (MNC). CK-positive cells were also detected in aptients with nonepithelial cell tumors in in normal donors, albeit at a lower frequency [0.38 (IHC) / 0.48 (FCM) and 0.45 (IHC) / 0.7 (FCM), respectively]. A treshold of _> 3 CK-positive cells wer 10(5) MNC was established as a positive result for tumor contamination. Based upon these criteria, 17 of 45 (38%) stage IV and 1 of 5 (20%) stage II/III patients were considered positive for tumor. No significant survival advantage was observed regardless of the CK status in this patient cohort. These results demonstrate that  sensitive assay for the detection of CK-positive cells was successfully developed to evaluate tumor burden in patients with breast cancer. The lack of correlation between the incidence of CK-positive cells and survival in stage IV patients most likely results from unresolved tumor in vivo following treatment. Future studies will focus on evaluation of a cohort of patients (stage II/III) with less advanced disease and the addition of more specific tumor markers.
Tracking and verification of tropical cyclone development in global ensemble prediction systems: evaluations during recent field programs
Creators: name: Snyder, Andrew David
Publisher: name: University of Utah
Year: 2012
Subjects: Cyclones
Tropics
NCEP
NRL

description: This study evaluated two global ensemble forecast systems from the National  Centers for Environmental Prediction (NCEP) and the Naval Research Laboratory (NRL)  in their performance of predicting the genesis and evolution of tropical cyclones. The  skill of the ensembles was assessed using cases studies from recent field programs. For  each model, the case studies consisted of five named tropical cyclones and two unnamed  nondeveloping tropical systems. The overall skill of ensemble forecasts, ensemble means  and spreads, and probabilities were verified.  Various tracking methods with different variables and vertical levels were compared  for effectiveness. A manual tracking method with three variables (vorticity maxima,  geopotential height and circulation) at the 850 hPa level was adopted to track tropical  cyclones in ensemble forecasts for both their pregenesis and postgenesis phases.  In the NCEP ensemble forecasts, the overall forecast skill of ensemble tracks and  intensity in the storm's pregenesis phase was relatively low. The forecast uncertainty  generally decreased with the reduction of forecast lead time, while the short-range  forecasts tended to be more accurate. In contrast, the skill of ensemble track forecasts  significantly improved for matured storms, possibly because of the implementation of the  NCEP storm relocation scheme. Although the high resolution deterministic GFS forecasts  were equal or better than the ensemble forecasts in almost half of the cases, the ensemble forecasts added value in predicting the probability of the tropical cyclone genesis. For  example, the ensemble spread could be a good indication of the forecast track errors.  Two versions of the NOG APS ensemble are compared: with and without the  addition of stochastic convection. The forecast skill of tropical cyclone tracks and  development from the NOG APS ensemble without stochastic convection was relatively  low, although it provided additional information over the deterministic control. Ensemble  track spreads were small and underdispersive in the control ensemble. Including  stochastic convection enlarged the ensemble track spread and enhanced genesis  predictability. The ensemble spread also showed a better correlation to the forecast track  errors, especially in the postgenesis phase. However, further evaluation showed that  weaker tropical systems could be over-intensified in the ensemble with stochastic  convection.
A new phenylheptanoid from the leaves of Gnetum gnemon L.
Creators: name: Le, Tho Huu
name: Van Do, Truong Nhat
name: Nguyen, Hai Xuan
name: Dang, Phu Hoang
name: Nguyen, Nhan Trung
name: Nguyen, Mai Thanh Thi
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Phytochemical study on the EtOAC-soluble extract of the leaves of Gnetum gnemon furnished the isolation of a new phenylheptanoid, gnetumal (1), along with five known compounds (2–6). Their isolation was carried out by using the column chromatography and their structures were elucidated based on the basis of the spectral interpretation. Bioactivity assay of these compounds indicated that gnetumal (1) and p-coumaric acid (5) possessed more potent tyrosinase inhibitory activity, with IC50 values of 31.6 and 2.3 µM, respectively, than that of a positive control kojic acid (IC50; 44.6 µM).
Design, validation, and implementation of a capnogram waveform simulator
Creators: name: Long, Christina Marie
Publisher: name: University of Utah
Year: 2012
Subjects: Anesthesia
Anesthesiology
Capnogram
Capnometer
Simulator

description: Current testing methods of capnometers do not test for a capnometer's ability to accurately calculate clinical parameters such as respiratory rate (RR) and end-tidal CO2 (ETCO2). Ideal standards should test capnometers with changing flow rates and frequencies of respiration, as well as with capnograms with complex shapes and trends. Simulators have been used in recent years as a solution for standardizing the testing of medical devices and dynamically evaluating their performance.  A CO2 waveform simulator was designed that continuously changes the flow rate of CO2 being injected into a constant flow of 02, in order to create varying CO2 partial pressures over time that mimic capnograms. The CO2 flow rate is computer-controlled through a variable orifice solenoid valve that outputs higher flow rates for higher input currents. Once the CO2 in injected into the O2 stream, the mixed gas is diverted to the reference capnometer, which is used to calibrate the CO2 valve and measure the simulator's performance.  Clinically recorded capnograms were used to validate the performance of the simulator by measuring how well the simulator reproduced the waveforms.
Mechanism of fatigue during maximal cycling exercise
Creators: name: Tomas, Aleksandar
Publisher: name: University of Utah
Year: 2012
Subjects: Bicycling
Kinetics

description: Numerous research models have been designed to investigate potential  mechanisms leading to fatigue during short-term maximal exercise. However, the  neuromuscular mechanisms responsible for fatigue are still a matter of debate and  interest, particularly in a human exercising model. Two likely mechanisms include  excitation/relaxation and force-velocity kinetics. In this study short cycle cranks (120  mm) were used to accentuate fatigue associated with muscle excitation/relaxation and  long cranks (220 mm) were used to emphasize contractile (force-velocity) origins of  fatigue. Fatigue index (peak power - min power / peak power) was used to quantify  fatigue. Ten competitive cyclists (7 male, 3 female) cycled maximally for 30 seconds on  crank lengths of 120 mm at 136 rpm and 220 mm at 110 rpm using an isokinetic cycling  protocol. Power data (averaged over a complete revolution of the cranks) were recorded  at 10 Hz with a power meter. Peak power did not differ between cranks (901 ± 309 W for  120 mm, and 898 ± 3 1 1 W for 220 mm,/? = 0.873). Fatigue index differed significantly  between cranks (57.5 ± 8.4% for 120 and 51.1 ± 11.3% for 220, p < 0.01). Work  performed also differed significantly between cranks (18.0 ± 5.5 kJ for 120 and, 19.2 ±  5.9 kJ for 220 p < 0.01). These results suggest that fatigue during a maximal short-term  exercise stems mainly from kinetics of excitation and relaxation of the sarcomere.  Improving fatigue resistance during maximal exercise may require improvements in the  processes of excitation and relaxation.
Composite treatment of ectomycorrhizal fungus Scleroderma bovista with two mycorrhiza helper bacteria augmented banj Oak (Quercus leucotrichophora A. Camus) growth
Creators: name: Yadav, Anurag
name: Dubey, R. C.
name: Yadav, Kusum
Publisher: name: figshare
Year: 2022
Subjects: subject: 60503 Microbial Genetics
subject: FOS: Biological sciences

description: Effect of composite inoculation of ectomycorrhizal fungi Scleroderma bovista along with two mycorrhizosphere bacterial inoculants was studied on banj oak (Quercus leucotrichophora A. Camus) plant growth in nursery glasshouse experiment. Seven treatments comprising of uninoculated control, two bacterial controls, one ectomycorrhizal (ECM) fungal control, two combinations of mycorrhizosphere bacteria and ECM fungus along with one composite inoculation of two bacteria with ECM fungus were used in the study. Dual treatment of S. bovita with Pseudomonas fluorescens MB9 yielded maximum shoot length (15.26 cm) and collar diameter (0.320 cm) of the plant. Triple inoculation of S. bovista with the two bacteria yielded maximum root length (36.86 cm), lateral roots (24.8), short roots (351.6), dry weight (6.746 g) and ectomycorrhizal colonization (39.2%). The study suggests the use of composite inoculation of native mycorrhizosphere bacteria like Bacillus subtilis, P fluorescens and others with Scleroderma bovista for the better growth of Q. leucotrichophora, which is a slow growing plant.
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 09.04.1967,erstellt vermutlich von Dendis am Skalnate Pleso Observatorium
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1967

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage am Skalnate Pleso Observatorium. Es sind zudem statistische Angaben für die Bestimmung der Fleckenrelativzahl notiert. Instrument: unbekannt, Sonnenbild D = 25 cm