cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
On the origin of cluster strengthening in aluminum alloys
Creators: name: De Vaucorbeil, Alban
Publisher: name: University of British Columbia
Year: 2015

description: Understanding the influence of atomic clusters formed during natural aging in aluminum alloys is a key problem to control more effectively the strength of alloys both during their processing and life. The yield strength of these alloys is controlled by the interaction between dislocations and solute atoms, and clusters. An empirical scaling law relating the dislocation-obstacle interaction force with the size of clusters has been developed and successfully used to predict the yield stress of a cluster strengthened AA6111 industrial aluminum alloy.It is proposed that the strengthening effect captured by the scaling law could come from the geometrical rearrangement of solute atoms from a random distribution to a clustered distribution, and/or from the change in strength of individual obstacles.A modified areal glide model was employed to investigate the statistical problem of a dislocation moving through a set of clustered point obstacles in the glide plane. The results of these simulations suggest that the degree of clustering of solute atoms does not influence the critical resolved shear stress. Then, molecular statics simulations were used to investigate the origin of the change in strength of individual clusters, in the simple case of Al-Mg alloys. A model based on elastic interaction between the solute atoms/clusters and an edge dislocation was developed and demonstrated to give good predictions for the maximum pinning force of single solutes, dimers and trimers. Using a detailed analysis of the model and the molecular statics simulations, it was shown that the strength of clusters principally comes from the elastic interaction between dislocations and solute atoms forming the clusters. Further, the change of topology of clusters was found to not significantly affect their strength at least in the case of Mg clusters in aluminum. Finally, this model was employed to determine the strengthening contribution of distributions of single solutes, dimers and trimers in binary Al-Mg alloys. The strength was found to roughly depend linearly on the size of clusters, however, its slope is lower than in the case of the AA6111 alloy which predominately contains a combination of Mg-Mg and Mg-Si clusters. The possible reasons for this discrepancy are discussed.
A novel optimization platform and its applications to the TRIUMF energy recovery linac
Creators: name: Gong, Chris
Publisher: name: University of British Columbia
Year: 2015

description: A novel software platform for global optimization was developed to create a baseline design for the TRIUMF Energy Recovery Linac (ERL). The platform is parallel capable, scalable, and allows flexible combinations of various accelerator tracking tools such as Madx and Free Electron Laser (FEL) tools such as Genesis. The TRIUMF machine includes simultaneously a two-pass ERL and a rare isotope line. Many parameters are coupled, including RF and the separator system which are shared for all three linac passes. The global optimization platform can study dynamic relationships between different processes, a practice not easily performed with piecewise optimization. The FEL induced energy spread, which grows by an order of magnitude after deceleration and increases the difficulty of beam disposal, creates a tradeoff, or Pareto front, between the gain and the dump energy spread. Another front forms between energy recovery and final energy spread due to RF settings. The Pareto fronts give insights on how objectives are related and the repercussions of design decisions. Pareto relationships are presented, along with potential lattice solutions found by the optimization platform.
A restauração do tomismo em Portugal no século XIX: as Instituições Christãs e a Academia de S. Tomás de Aquino em Coimbra(1880-1893)
Creators: name: Estevão, Nuno
Publisher: name: Lusitania Sacra
Year: 2004

description: Com o presente artigo, problematiza-se a restauração do tomismo em Portugal a partir das iniciativas desenvolvidas em Coimbra por D. Manuel Correia de Bastos Pina. Começando a funcionar em 1880, a Academia de S. Tomás de Aquino constitui o elemento de articulação das diferentes acções desencadeadas. O seu principal factor de visibilidade reside nas Instituições Christãs, publicação periódica iniciada em 1883 e que, até 1893, possui uma assinalável regularidade. A restauração do tomismo é um dos vectores da estratégia de Bastos Pina no governo da diocese. O horizonte é a contraposição à crítica das ciências modernas à religião católica e ao lugar da Igreja na sociedade. O ralliement é o outro elemento estruturador da estratégia que Bastos Pina projecta e aplica. A Academia e a revista são compreendidas como os principais instrumentos para proceder à recuperação do tomismo. Percorrendo as suas principais etapas, procura-se explicar como a génese e a estabilização destas iniciativas contribuem para a divulgação da doutrina em Coimbra, enquanto a acção de Tiago Sinibaldi, com o recurso a outros meios, permite alargar o âmbito de intervenção.
description: Lusitania Sacra, n. 16 (2004): Mutações Religiosas na Época Contemporânea: Figuras e Pensamento
Topological parameters in gravity
Creators: name: Kaul, Romesh K.
name: Sengupta, Sandipan
Publisher: name: arXiv
Year: 2011
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We present the Hamiltonian analysis of the theory of gravity based on a Lagrangian density containing Hilbert-Palatini term along with three topological densities, Nieh-Yan, Pontryagin and Euler. The addition of these topological terms modifies the symplectic structure non-trivially. The resulting canonical theory develops a dependence on three parameters which are coefficients of these terms. In the time gauge, we obtain a real SU (2) gauge theoretic description with a set of seven first class constraints corresponding to three SU (2) rotations, three spatial diffeomorphism and one to evolution in a timelike direction. Inverse of the coefficient of Nieh-Yan term, identified as Barbero-Immirzi parameter, acts as the coupling constant of the gauge theory.
description: references added
Additional file 1 of Comparison of 3-factor versus 4-factor prothrombin complex concentrate for emergent warfarin reversal: a systematic review and meta-analysis
Creators: name: Margraf, David J.
name: Brown, Sarah J.
name: Blue, Heather L.
name: Bezdicek, Tamara L.
name: Wolfson, Julian
name: Chapman, Scott A.
Publisher: name: figshare
Year: 2022
Subjects: Medicine
Biotechnology
Science Policy
Hematology

description: Additional file 1.
Il vescovo Giovanni si è fermato a Montebelluna
Creators: name: Salvador, Silvano
Publisher: name: Knowledge Commons
Year: 2025
Subjects: subject: Cartography

description: Quando presi in esame il saggio "Berua, raeticum oppidum dei Beruenses" di Franco Luciani (in "Geographia antiqua", anno 2016, pp. 99-127) mi venne voglia di escogitare qualunque cosa mi passasse per la testa pur di giustificare l'assunto dello studioso trevigiano, che identifica lo scomparso municipium romano di Berua con Montebelluna...
Science for Peace in the Benefit of Humankind. The Hippocratic Oath for Scientists concept
Creators: name: Lemarchand, Guillermo A.
Publisher: name: arXiv
Year: 2010
Subjects: subject: History and Philosophy of Physics (physics.hist-ph)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences

description: This article shows the importance that has had the scientific research, the technological development and the innovation processes in increasing the lethality of the available weapons during the last century. A set of initiatives promoted by the scientific community to stop the nuclear arms race that threatened the continuation of life on the planet is described. At this point, a thorough survey of the texts and proposals of Hippocratic Oaths for Scientists presented at different epochs is made. It is observed that the interest in linking ethical aspects with science and technology issues shows an exponential growth behavior since the Second World War. It is shown how the several proposals of oaths and ethical commitments for scientists, engineers and technologists are disseminated following a logistic growth behavior, in the same manner as a disembodied technology in a particular niche. The data analysis shows that there is a coincidence between the maximum rate of proposals and the historical moment at which the world had deployed the largest number of nuclear warheads (70,586) as well as the largest world military expenditures in history (USD 1,485,000,000,000). Subsequently, the origin of the Hippocratic Oath for Scientists used for more than two decades in graduation ceremonies at the Faculty of Exact and Natural Sciences of the University of Buenos Aires is analyzed and linked with the historical circumstances of its birth.
description: in Spanish, 71 pages, 6 figures, 8 photos/facsimil, 4 tables, 1 annex with references and texts of 90 Hippocratic Oaths for Scientists, UNESCO Conference Proceedings
Il vescovo Giovanni si è fermato a Montebelluna
Creators: name: Salvador, Silvano
Publisher: name: Knowledge Commons
Year: 2025
Subjects: subject: Cartography

description: Quando decisi di esaminare il saggio "Berua, raeticum oppidum dei Beruenses" di Franco Luciani (in "Geographia antiqua", anno 2016, pp. 99-127) provai ad escogitare qualunque cosa mi passasse per la testa pur di giustificare l'assunto dello studioso trevigiano, che identifica lo scomparso municipium romano di Berua con Montebelluna...
Additional file 1 of Intravenous vitamin C administration to patients with septic shock: a pilot randomised controlled trial
Creators: name: Rosengrave, Patrice
name: Spencer, Emma
name: Williman, Jonathan
name: Mehrtens, Jan
name: Morgan, Stacey
name: Doyle, Tara
name: Van Der Heyden, Kymbalee
name: Morris, Anna
name: Shaw, Geoff
name: Carr, Anitra C.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Computational Biology

description: Additional file 1. Supplemental material: Figure S1–S5.
title: 'All that associates, saves': Hawthorne biography and twentieth-century American cultural criticism
Creators: name: Groth-Seary, Angela Groth-Seary
Publisher: name: University of Kent
Year: 2021

description: This study gives an account of the roles that biographies of Nathaniel Hawthorne, a nineteenth-century American writer, have come to play within the twentieth-century discourses concerned with American literature as a national literature and as a field of academic inquiry. While attempting to outline the general development of Hawthorne biography in this context, it concentrates mainly on three Hawthorne biographies and on the historical, intellectual and political contexts within which they were produced: Newton Arvin's Hawthorne, published in 1929, Randall Stewart's Nathaniel Hawthorne: A Biography (1948), and Walter Herbert's Dearest Beloved: The Hawthornes and the Making of the Middle-class Family (1993). Each of these lives has been a benchmark in Hawthorne biography; they have introduced new theories and methods and have been embraced by some contemporary critics but contested by others. The first chapter of this thesis outlines debates about biographical practice in a specifically American context. Chapter 2 reads the Hawthorne biographies of the 1920s in the context of Van Wyck Brooks's call to 'create a usable past'. Chapter 3 examines the Hawthorne biographies of the late 1940s, paying particular attention to the ways in which politically conservative or liberal values are inscribed in them and situating them in relation to the attitudes towards biography on the part of practitioners of the New Criticism on one hand and of historical scholarship on the other. Chapter 4 explores new developments in Hawthorne biography since the early 1980s and specifically analyses Herbert's 'new historicist' study of the nuclear Hawthorne family in the light of David Reynolds's notion of 'cultural biography'. The thesis ends with a conclusion which considers the forms in which Hawthorne biography might continue in the twenty-first century.
Rough peace : understanding the avoidance of armed conflict in Bolivia
Creators: name: Prest, Stewart
Publisher: name: University of British Columbia
Year: 2015

description: Why and how does peace persist in some contentious political contexts, but not others? I argue that certain forms of locally embedded governance institutions can play an important role in mitigating the likelihood of armed violence. Specifically, I find that inclusive communities equipped with governance institutions capable of resolving collective action problems—which I refer to as “Ostromian communities”—are, under a range of conditions, less likely to engage in armed conflict with other communities or the state. The research employs a method of process tracing on the basis of 70 participant and expert interviews, primary document collection and analysis and other archival research in the primary case of contestation over coca eradication in the Chapare region of Bolivia from 1982 until 2004. First, I illustrate how the coca growers’ federations constituted an Ostromian community. Second, I show how the federations’ inclusive political institutions encouraged and enabled high levels of coordinated and contentious non-violent political activity, but stopped short of armed resistance. This outcome resulted despite a repressive state presence in the region and regular instances of violence directed against the community occurring over a period of more than two decades. The dissertation makes several contributions to the civil conflict literature. It provides a novel explanation for why and how some countries at risk of civil conflict—such as those with unconsolidated political regimes or limited state capacities—tend to persist indefinitely in a state of rough, yet durable peace, while others experience conflict.
The impact of obesity and uncontrolled asthma during pregnancy on metabolic and inflammatory pathways
Creators: name: Bhaumik, Sreeparna
name: Lockett, Jack
name: Saif, Zarqa
name: Lai, Andrew
name: Salomon, Carlos
name: Whitehead, Jonathan P.
name: Clifton, Vicki L.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Asthma and obesity are both inflammatory complications of pregnancy and when combined contribute to an increased risk of uncontrolled asthma during pregnancy and poor perinatal outcomes. Our previous work has identified the presence of maternal asthma is associated with a proinflammatory milieu in the placenta and reduced fetal growth. The current study was designed to determine the relationships between immunomodulatory metabolic pathways and inflammation and establish whether these pathways are associated with uncontrolled asthma in obese pregnant women. Fifty-three obese (BMI >30) pregnant women were recruited prospectively. Participants were classified as having no asthma, controlled asthma, and uncontrolled asthma based on a doctor diagnosis and assessment using the Asthma Control Questionnaire (ACQ). Circulating plasma concentrations of metabolic hormones leptin, adiponectin, insulin, glucose, and extracellular vesicle (EVs) associated cytokines were measured at 18- and 36-weeks gestation. Concentrations of metabolic and inflammatory markers among obese participants with or without asthma were not significantly different throughout gestation. However total adiponectin concentrations increased as gestation progressed in obese, non-asthmatic women but did not increase in women with asthma. Plasma adiponectin and leptin levels in women with uncontrolled asthma were positively correlated with EV inflammatory markers including GM-CSF, IL-6, TNFα and IFNγ protein. This study demonstrated that most metabolic markers remain unchanged with the presence and severity of asthma in obese pregnant women. However, differences in the associations between metabolic and inflammatory pathways were observed in women with asthma and may be one of the mechanisms contributing to uncontrolled asthma in obese pregnant women.
On Small deviations of Gaussian processes using majorizing measures
Creators: name: Weber, Michel
Publisher: name: arXiv
Year: 2010
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: Primary: 60F15, 60G50, Secondary: 60F05

description: We give two examples of periodic Gaussian processes, having entropy numbers of exactly same order but radically different small deviations. Our construction is based on classical Knopp's result yielding of existence of continuous nowhere differentiable functions, and more precisely on Loud's functions. We also obtain a general lower bound for small deviations using the majorizing measure method. We show on examples that our bound is sharp. We also apply it to Gaussian independent sequences and to the generic class of ultrametric Gaussian processes. 60F15, 60G50 ; Secondary: 60F05
Extinção das Ordens Religiosas e dinâmicas sócio-culturais: frades residentes no Alto-Minho no Século XIX
Creators: name: Rodrigues, Henrique
Publisher: name: Lusitania Sacra
Year: 2004

description: Com a publicação do decreto de 28 de Maio de 1834, frades, cenobitas e outros religiosos sentiram os efeitos do regalismo liberal. Depois de espoliados de todos os haveres, para usufruírem da prestação concedida pelo Estado, deviam candidatar-se a uma prestação, requerendo esse mesmo subsídio. Com este estudo, é possível saber quem eram os egressos “prestacionistas” residentes na região do Alto-Minho, que nome civil tinham e qual a identificação conventual, a idade, as condições físicas, psicológicas, intelectuais e, acima de tudo, descobrimos o perfil de competências para o desempenho de qualquer actividade profissional e as habilitações académicas destes monges. Ao estudarmos os níveis etários, naturalidade, ordem e convento de proveniência, locais de fixação, preparação académica e outros elementos, conseguimos perceber o impacto sócio-cultural dos Frades fixados nas paróquias deste distrito administrativo, verdadeiros agentes da alfabetização do Alto-Minho no século XIX, leccionando em escolas públicas, privadas e ministrando o ensino doméstico.
description: Lusitania Sacra, n. 16 (2004): Mutações Religiosas na Época Contemporânea: Figuras e Pensamento
Additional file 1 of Developing a simulation safety policy for translational simulation programs in healthcare
Creators: name: Brazil, Victoria
name: Scott, Clare
name: Matulich, Jack
name: Shanahan, Brenton
Publisher: name: figshare
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Neuroscience
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer

description: Additional file1. Infographic simulation safety policy.
Logarithmic intertwining operators and the space of conformal blocks over the projective line
Creators: name: Arike, Yusuke
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Algebra (math.QA)
subject: FOS: Mathematics
subject: 17B69, 81T40

description: We show that the space of logarithmic intertwining operators among logarithmic modules for a vertex operator algebra is isomorphic to the space of 3-point conformal blocks over the projective line. This is considered as a generalization of Zhu's result for ordinary intertwining operators among ordinary modules.
description: 15 pages
Supplemental material.docx
Creators: name: Demin Gao
name: Haiyang Feng
name: Hailu Cao
name: Beibei Chong
name: Liu, Li
name: Fan, Ya
name: Yingying Zhang
Publisher: name: figshare
Year: 2020
Subjects: subject: 60701 Phycology (incl. Marine Grasses)
subject: FOS: Biological sciences

description: 各种火鹤属植物的叶子已被证明具有抗菌和消炎的特性，并已广泛用于中药中。但是，很少有研究调查了吡咯虫属植物的活性成分。在这项研究中，使用超高效液相色谱-四极杆-活性轨道阱质谱（UPLC-MS / MS）分离和鉴定了四种火鹤草的类黄酮和酚酸。使用1,1-二苯基-2-吡啶并肼基（DPPH），还原能力测定，羟基自由基清除测定，磷钼抗氧化剂活性和体内抗氧化剂活性评价抗氧化剂的性能。UPLC-MS / MS显示总共鉴定出19种黄酮类化合物，其中 首次从吡咯菌属中分离出雌雄七醇-7-O-葡糖苷（8）和山奈酚-3-O-芸香苷（12）。芹菜素（16），genkwanin（18）和熊果酸（19）也是首次从灰熊火棘中分离出来。这项研究是第一个确定吡咯菌提取物总黄酮和酚类化合物含量并确认其高抗氧化性能的研究。
Achieving zero asthma-related hospitalisations in the world´s first SABA-free Asthma Center in Argentina
Creators: name: Nannini, Luis J.
name: Brandan, Nadia
name: Fernandez, Octavio M.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Achieving zero asthma-related hospitalisations in the world´s first SABA-free Asthma Center in Argentina
Particle trajectories beneath small amplitude shallow water waves in constant vorticity flows
Creators: name: Ionescu-Kruse, Delia
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mathematical Physics (math-ph)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences
subject: 76B15, 76F10, 37N10

description: We investigate the particle trajectories in a constant vorticity shallow water flow over a flat bed as periodic waves propagate on the water's free surface. Within the framework of small amplitude waves, we find the solutions of the nonlinear differential equations system which describes the particle motion in the considered case, and we describe the possible particle trajectories. Depending on the relation between the initial data and the constant vorticity, some particle trajectories are undulating curves to the right, or to the left, others are loops with forward drift, or with backward drift, others can follow some peculiar shapes.
Comparing the effectiveness of a traditional versus an alternative outpatient cardiac rehabilitation model
Creators: name: Gabelhouse, Jacqueline Brigitte Monique
Publisher: name: University of British Columbia
Year: 2015

description: It has been demonstrated that participation in cardiac rehabilitation (CR) elicits improvements in health related quality of life (HRQOL), exercise tolerance, cardiac risk factors, and all-cause mortality rates in patients with cardiovascular disease (CVD). Despite the aforementioned benefits associated with CR, enrollment and participation rates remain low (30%) due to a number of barriers including accesibility, financial constraints, time conflicts, the referral process, and participant interests. Due to the sub-optimal enrollment of CR programs, alternative CR models have been developed to provide greater flexibility for patients in terms of accessibility, interests, affordability and preferences. However, little is known about the effectiveness of this alternative model, or more specifically, whether these alternative models result in similar positive benefits associated with traditional cardic rehabilitation models (TM). Thus, the purpose of this study was to compare the effectiveness of a traditional model (TM) to an alternative, hybrid model (HYM) for CR in terms of health related quality of life and secondary outcome measures (i.e., physical activity, resting blood pressure, cholesterol profile, blood sugars, metabolic equivalents, smoking status, fruit and vegetable intake, depressive symptoms, and anthropometrics). This study was a prospective, two-armed non-randomized intervention consisting of 125 cardiac patients from the Central Okanagan. Participants choose to enroll in a TM (n=72) or an alternative HYM (n=53) CR program. Of 125 participants, 88% completed the programs. Mean age of the participants was 67.1±10.6 years and 70.4% were male. The results of the two way-analysis of variance (ANOVA) showed no significant interaction between models. However, statistically significant improvements were observed over time in HRQOL (p<.001). The secondary outcome measures found statistically significant improvements over time for physical activity (p<.001), systolic blood pressure (p<.001), total cholesterol (p<.001), low density lipoprotein (p<.001), METs (p<.001), reductions in smoking status (p=.043), dietary behaviors (p<.001), depressive symptoms (p<.001), and waist circumference (p<.001). Study results indicate that an 8 week HYM in a CR setting may be as effective as a TM for changing health promoting behaviours specific to those with CVD.
Primary antibody deficiencies represent an underestimated comorbidity in asthma patients: efficacy of immunoglobulin replacement therapy in asthma control
Creators: name: Vivarelli, Emanuele
name: Matucci, Andrea
name: Parronchi, Paola
name: Liotta, Francesco
name: Cosmi, Lorenzo
name: Rossi, Oliviero
name: Cavigli, Edoardo
name: Vultaggio, Alessandra
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Primary antibody deficiencies (PAD) are an underestimated comorbidity in asthma and its treatment could improve disease control. a retrospective cohort of asthmatics, affected by IgG subclass deficiency or unclassified antibody deficiency and treated with low-dose intravenous immunoglobulin replacement therapy (IRT) was recruited. Demographic and clinical data, chest CT scan, blood eosinophils, atopy, chronic oral corticosteroid (OCS) therapy were evaluated at baseline. Asthma exacerbations, lower respiratory tract infections (LRTI), upper respiratory tract infections (URTI) and asthma-related hospitalizations were assessed after one and two years of IRT. 57 moderate-to-severe asthmatics were enrolled, mostly affected by T2 low asthma (39/57, 68.4%). After one year, IRT was effective in improving, irrespective of bronchiectasis, atopy, eosinophils and PAD type: 1) trough IgG (826.9 ± 221.3 vs 942.2 ± 195.1 mg/dl; p < 0.0001) and IgG subclasses (IgG1 355.4 ± 88.4 vs 466.7 ± 122.3, p < 0.0001; IgG2 300.1 ± 130.1 vs 347.6 ± 117.3, p < 0.0005) serum levels. 2) asthma exacerbations (6.4 ± 4.1 vs 2.4 ± 1.9, p < 0.0001), LRTI (4.3 ± 3.9 vs 1.3 ± 1.5, p < 0.0001) and hospitalization rate (0.26 ± 0.7 vs 0.05 ± 0.2, p < 0.01). These results persisted after 2 years of therapy. Estimated mean cumulative OCS exposure was reduced by 4500 mg over the 2-year period. low-dose IRT is effective in improving asthma control and lessening OCS burden in asthmatics affected by PAD.
Dealing with uncertainty in health economic decision modeling. Applying statistical and data science methods
Creators: name: Scholz, Stefan
Publisher: name: Universität Bielefeld
Year: 2021
Subjects: subject: 330

description: Health economic decision modeling is a widely used method to support decision makers in the health care sector choosing cost-effective interventions. Modeling allows to combine evidence from various sources and to compare different treatment strategies that exceed the feasible number of comparators in clinical trials. New, increasingly complex health technologies need to be reflected by more complex models and need to be informed by more data. Additionally, more detailed models come with more and new types of uncertainties surrounding model input, model structure and methodological choices.
 The aim of the present dissertation thesis is twofold: First, statistical and data science methods are explored to deal with the increased data demand of more complex models and to be applied for the classical forms of uncertainty. The second goal is the exploration of a new source of uncertainty originating from the heuristic nature of new model types like agent-based modeling – namely uncertainty associated with the algorithms used to simulate agent behavior.
 The thesis is comprised of eight articles published in international, peer-reviewed journals. The first six articles are dedicated to the application of statistical and data science methods to model uncertainties regarding parameters, methodological and structural choices. The publications show how new methods, for example web-scraping, can be used to inform behavioral, epidemiological as well as health economic input parameters of models. They also present how uncertainties can be explored and communicated to decision makers. The last two articles explore the influence of algorithmic uncertainty in agent-based models used in infectious disease modeling. The results show the extent in which matching algorithms influence the spread of a sexually transmitted infection.
 The thesis demonstrates that new statistical and data science methods allow the use of more detailed, complex models to answer very specific research questions. This allows decision makers to find tailored, cost-effective interventions. However, these new model types also come with new uncertainties that must be communicated to the decision makers to fully account for the uncertainty surrounding the model results.
First results of site testing program at Mt. Shatdzhatmaz in 2007 - 2009
Creators: name: Kornilov, V.
name: Shatsky, N.
name: Voziakova, O.
name: Safonov, B.
name: Potanin, S.
name: Kornilov, M.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: We present the first results of the site testing performed at Mt.~Shatdzhatmaz at Northern Caucasus, where the new Sternberg astronomical institute 2.5-m telescope will be installed. An automatic site monitor instrumentation and functionality are described together with the methods of measurement of the basic astroclimate and weather parameters. The clear night sky time derived on the basis of 2006 -- 2009 data amounts to 1340 hours per year. Principle attention is given to the measurement of the optical turbulence altitude distribution which is the most important characteristic affecting optical telescopes performance. For the period from November 2007 to October 2009 more than 85\,000 turbulence profiles were collected using the combined MASS/DIMM instrument. The statistical properties of turbulent atmosphere above the summit are derived and the median values for seeing $β_0 = 0.93$~arcsec and free-atmosphere seeing $β_{free} = 0.51$~arcsec are determined. Together with the estimations of isoplanatic angle $θ_0 = 2.07$~arcsec and time constant $τ_0 = 2.58 \mbox{ ms}$, these are the first representative results obtained for Russian sites which are necessary for development of modern astronomical observation techniques like adaptive optics.
description: Accepted for publication in MNRAS, 17 pages, 15 figures
Additional file 1 of Strategies for the implementation of clinical practice guidelines in public health: an overview of systematic reviews
Creators: name: Pereira, Viviane C.
name: Silva, Sarah N.
name: Carvalho, Viviane K. S.
name: Zanghelini, Fernando
name: Barreto, Jorge O. M.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Literature search.
Perfectionism literacy among teachers and trainee teachers: Evaluating the use of a short educational video
Creators: name: Etherson, Marianne E.
name: Hill, Andrew P.
Publisher: name: PsychArchives
Year: 2025
Subjects: subject: Perfectionism
subject: mental health
subject: literacy
subject: teachers
subject: 150

description: Perfectionism is related to mental health and wellbeing issues in teachers and students. One way of helping prevent harmful perfectionism related issues arising is to increase perfectionism literacy among teachers. That is, what teachers know about perfectionism, its features, risks, and where support can be found if needed. This knowledge may help prevent problems for themselves and also help them support their students. In support of this possibility, a recent measure of perfectionism literacy has been developed, termed the Perfectionism Literacy Questionnaire, which assesses knowledge of multidimensional trait perfectionism (Etherson et al., 2025). In support of its use, evidence was found among community adults that it is distinct from perfectionism (i.e., being perfectionistic is not the same as knowing about perfectionism) and perfectionism literacy is related to help-seeking behaviours, generally. In addition, some initial evidence was provided that perfectionism literacy can be increased using a cheap, scalable intervention - a short educational video. In the current study, we build on this initial research by examining the effectiveness of the same educational video on perfectionism literacy levels in teachers and trainee teachers.
Single-cell analysis of hematopoietic stem cell identity and behaviour
Creators: name: Knapp, David Jorg Hans Fraser
Publisher: name: University of British Columbia
Year: 2015

description: The concept of stem cell self-renewal was developed from clonal tracking of hematopoietic stem cell (HSC) divisions in vivo 50 years ago. However, protocols to expand these cells in vitro without loss of their stem cell properties have remained elusive. A number of factors contribute to this inability. Key among these is a lack of knowledge of the critical molecular characteristics that distinguish HSCs from hematopoietic progenitors as well as how the control of the fundamental biological programs of survival, division and differentiation are integrated in HSCs. Using a combination of single-cell tracking, transcriptomics, and in vivo readouts applied to highly enriched mouse HSCs, we now show that their survival, proliferation, and maintenance of stem cell properties are mechanistically dissociable. Discovery of a protocol that allows input numbers of functionally intact human HSC numbers to be maintained for 3 weeks in vitro using defined growth factors, was then leveraged to design single human HSC cell tracking and functional analyses. The results of these showed that for human HSC, as in the mouse model, survival, proliferation, and maintenance of stem cell status are mechanistically dissociable, and controlled in a combinatorial manner. We then developed a panel of mass cytometry detectors to enable >40 surface and intracellular proteins to be simultaneously measured at single cell resolution. Using this panel, we identified some of the signaling intermediates activated by growth factors that differentially control human HSC biological responses assessed in high-throughput assays. Correlation of the molecular properties, surface phenotypes and functional activities of CD34+ subsets have further revealed a surprising degree both of heterogeneity within each phenotype and overlap between phenotypes. In some cases, the results suggest a given phenotype contains distinct subsets and a broader scheme of differentiation pathways than suggested by current models of human hematopoietic cell differentiation. Finally, we identify CD33+ as a novel marker which demarcates the most potent human HSC within the current best phenotypic enrichment strategy. These results lay a foundation on which future HSC expansion strategies can be constructed, and have implications for the development of leukemia.
ความรู้ ความเข้าใจ และพฤติกรรมการป้องกัน การติดเชื้อเอชไอวี และโรคติดต่อทางเพศสัมพันธ์ ในกลุ่มชายที่มีเพศสัมพันธ์กับชาย จังหวัดสงขลา
Creators: name: ภูโมกข์ อัมพวา
Publisher: name: Division of AIDS&STIs
Year: 2019
Subjects: เอชไอวี
โรคติดต่อทางเพศสัมพันธ์
ชายรักชาย
การติดเชื้อเอชไอวี

description: Thai AIDS Journal, 31, 1, 21-31
Ergodicity from Nonergodicity in Quantum Correlations of Low-dimensional Spin Systems
Creators: name: Prabhu, R.
name: De, Aditi Sen
name: Sen, Ujjwal
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Correlations between the parts of a many-body system, and its time dynamics, lie at the heart of sciences, and they can be classical as well as quantum. Quantum correlations are traditionally viewed as constituted out of classical correlations and magnetizations. While that of course remains so, we show that quantum correlations can have statistical mechanical properties like ergodicity, which is not inherited from the corresponding classical correlations and magnetizations, for the transverse anisotropic quantum XY model in one-, two-, and quasi two-dimension, for suitably chosen transverse fields and temperatures. The results have the potential for applications in decoherence effects in realizable quantum computers.
description: 8 pages, 6 figures, RevTeX 4.1
TOJAL, Alexandre Arménio; PINTO, Paulo Campos – Bandeiras das Misericórdias. Coord. de Natália Correia Guedes. Lisboa: Comissão para as Comemorações dos 500Anos das Misericórdias, 2002. 166 p.
Creators: name: Soalheiro, João
Publisher: name: Lusitania Sacra
Year: 2003

description: Lusitania Sacra, n. 15 (2003): Poder, Sociedade e Religião na Época Moderna
The true nature of Terzan 5: the most efficient "furnace" of MSPs in the Galaxy
Creators: name: Ferraro, Francesco R.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Terzan5 is the globular cluster (GC)-like stellar system harboring the largest known population of MSPs. Using the Multi-Conjugate Adaptive Optics demonstrator MAD at the ESO - VLT, we recently obtained a superb (K, J - K) color-magnitude diagram, which has revealed the existence of two horizontal branches (HBs) well separated in magnitude and colour (Ferraro et al. 2009, Nature,462, 483). A prompt spectroscopic follow-up with NIRSPEC@Keck has shown that the two populations have (1) significantly different iron content ([Fe/H]= -0.2 and +0.3 for the faint and the bright HB, respectively), (2) distinct [alpha/Fe] abundance patterns and (3) no evidence of the Al-O anti-correlation commonly observed in GCs. All these properties suggest that Ter 5 is far from being a genuine globular. Instead it has experienced the explosion of a huge number of supernovae (SNe), thus accounting for its high metal content and it should have been much more massive in the past than today, thus to retain the SN ejecta within its potential well. The many type II SNe should have also produced a large number of neutron stars (NSs), which could finally explain its exceptionally large population of MSPs.
description: Contributed Talk at the conference "Radio Pulsars: a key to unlock the secrets of the Universe", Baia Chia, Sardinia, Italy, 11-15 Oct. 2010, 4 pages, 2 figures
Additional file 2 of Strategies for the implementation of clinical practice guidelines in public health: an overview of systematic reviews
Creators: name: Pereira, Viviane C.
name: Silva, Sarah N.
name: Carvalho, Viviane K. S.
name: Zanghelini, Fernando
name: Barreto, Jorge O. M.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2. Excluded studies.
Understanding decision-making and educational need in the management of pediatric patients with moderate-to-severe asthma: analysis of a US-based clinician survey
Creators: name: Salinas, Gregory D.
name: Wiley, Shereta
name: Stacy, Sylvie
name: Gall, Rebecca
name: Wright-Bello, Lakiea
name: Mandarakas, Anthia
name: Ruiz-Cordell, Karyn
name: Gilbride, Joseph
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Background: Asthma creates a substantial burden on the pediatric healthcare system, particularly by those with moderate-to-severe disease. As few studies have been published specific to clinician evaluation and management of this population, this analysis serves to begin to identify educational needs and potential clinical impact.Methods: We conducted a case-based survey of US general pediatric (n = 227), allergy (n = 158), and pediatric pulmonology (n = 70) clinicians to understand the current approach to management of pediatric patients with moderate-to-severe asthma.Results: Results show inconsistencies in guideline adherence, identification of disease severity and control, referral practices, and knowledge of phenotypes, which may impact clinical decision making. While most clinicians refer to guidelines when managing pediatric patients with moderate-to-severe asthma, there is no preferred set, and they find the guidelines to be moderately useful. General pediatricians are more likely than specialists to have difficulty distinguishing control and severity and may not be familiar with the concept of asthma phenotype. Most surveyed pediatricians indicated they refer patients to a specialist, but did not always do so in the cases. Clinicians have little consensus on the best approach to manage patients with uncontrolled symptoms after optimized therapy. Many clinicians may have uncertainty about how elevated eosinophils or FeNO could affect patient management. Further, there may be gaps in incorporating parents and pediatric patients into shared decision-making in their care.Conclusions: Understanding the needs of those managing patients with moderate-to-severe asthma is critical to developing effective continuing education activities to improve patient outcomes.
Regulation of raw264.7 macrophage polarization on smooth and rough topographies by galectin-3
Creators: name: Kianoush, Fariba
Publisher: name: University of British Columbia
Year: 2015

description: Surface topography can modulate cytokine gene expression and protein secretion in macrophages. Although phosphoinositide 3-kinase (PI3K) has been found to have a key role in the induction of the alternatively activated phenotype (M2) by interleukin 4 (IL-4), the pathways involved in topographic modulation of phenotype are largely unknown. This study examined the effect of polished (PO) and three rough surfaces, SLA (Sandblasted Large-grit Acid-etched surface which is a well-documented and widely used implant surface) and two novel grooved topographies G1 and G2 produced by anisotropic etching of Si <110> for their effects on RAW 264.7 macrophage gene expression and morphology using real time quantitative polymerase chain reaction (RT-qPCR). We hypothesized that the galectin-3/ CD98/ integrin β1 complex was involved in phenotype regulation. The hypothesis was tested by blocking attachment of galectin- 3 (gal-3) to CD98 by lactose. The G1 and G2 surfaces caused the macrophages to adopt an elongated M2-like morphology. In the presence of lactose the M2 markers were downregulated but the M1 marker was upregulated on smooth and rough surfaces. Thus the inhibition of gal-3 binding to integrin skewed macrophages phenotype towards the M1 phenotype and the effects of topography were thus abrogated. To test if PI3K is involved in regulation of macrophage phenotype on rough and smooth topographies (without any exogenously added IL-4/IL-13), we studied the effects of the PI3K inhibitor, LY294002, on phenotype markers. As expected from the results with IL-4 induced polarization, an M2 marker (the mannose receptor) was downregulated on both PO and G1 surfaces. Our data suggest that galectin-3 dependent CD98 interaction with integrin β1 skewed RAW264.7 cells toward an M2-like phenotype on both smooth and rough surface topographies through CD98-activated PI3K. Furthermore, we report that rough surface topography plays a substantive role in directing macrophages towards the M2 phenotype. This was reflected in both M2 marker expression and cellular morphology.
Exact solutions for small-amplitude capillary-gravity water waves
Creators: name: Ionescu-Kruse, Delia
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mathematical Physics (math-ph)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We present explicit solutions for the ordinary differential equations system describing the motion of the particles beneath small-amplitude capillary-gravity waves which propagate on the surface of an irrotational water flow with a flat bottom. The required computations involve elliptic integrals of first kind, the Legendre normal form and a solvable Abel differential equation of the second kind.
A IGREJA no mundo operário: contributos para a história da Liga Operária Católica e da Liga Operária Católica Feminina (1936-1974). Coimbra: Gráfica de Coimbra, 2002. 308 p.
Creators: name: Fontes, Paulo
Publisher: name: Lusitania Sacra
Year: 2003

description: Lusitania Sacra, n. 15 (2003): Poder, Sociedade e Religião na Época Moderna
Examining the French and English language proficiency of grade 11 French immersion students in British Columbia
Creators: name: Rustom, Anahita Afrin
Publisher: name: University of British Columbia
Year: 2015

description: The primary objective of the present study was to compare the French and English language proficiency of Early French Immersion (EFI) and Late French Immersion (LFI) students nearing the time of high-school graduation. This research was undertaken as a means of exploring the effect of age on second language proficiency, in the context of French immersion. Four indicators of language proficiency were examined: receptive vocabulary knowledge, grammar knowledge, listening comprehension, and pronunciation. Participants were evaluated in French and English. Results demonstrated no significant differences between EFI and LFI groups on the French language measures, suggesting evidence against the notion of a sensitive period for language learning in the context of French immersion. Subsequent analyses were conducted in which the sample was divided by home-language into bilinguals (participants who spoke only English at home) and multilinguals (participants who spoke a language other than English at home). These analyses revealed that multilinguals performed as well as, and on some measures better than bilinguals in both languages, with the exception of English pronunciation. Higher language aptitude and motivation to learn a foreign language observed in the multilingual group were factors that could explain these results. Due to the better performance of multilinguals and the uneven distribution of multilinguals across EFI and LFI groups, it is unclear whether this study provides evidence against age effects in formal language education. The results emphasize the success of multilinguals in EFI and LFI, but also highlight the need to account for the changing demographics of students in French immersion programs in future studies.