cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Pudicitia: The Construction and Application of Female Morality in the Roman Republic and Early Empire
Creators: name: Joseph, Kathryn
Publisher: name: Brandeis University
Year: 2018
Subjects: Pudicitia
Roman Women

description: In the Roman Republic and early Empire, pudicitia, a woman’s sexual modesty, was an important part of the traditional concept of female morality. This thesis strives to explain how traditional Roman morals, derived from the foundational myths in Livy’s History of Rome, were applied to women and how women functioned within these moral constructs. The traditional constructs could be manipulated under the right circumstances and for the right reasons, allowing women to act outside of traditional gender roles. By examining literary examples of women who were able to step outside of traditional gender roles, it becomes possible to understand the difference between projected male ideas on ideal female morality, primarily pudicitia, and actuality.
Influence of relative NK–DC abundance on placentation and its relation to epigenetic programming in the offspring
Creators: name: Freitag, N.
name: Zwier, M. V.
name: Barrientos, G.
name: Tirado-González, I.
name: Conrad, M. L.
name: Rose, M.
name: Scherjon, S. A.
name: Plösch, T.
name: Blois, S. M.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::619 Gynäkologie, Pädiatrie, Geriatrie

description: Normal placentation relies on an efficient maternal adaptation to pregnancy. Within the decidua, natural killer (NK) cells and dendritic cells (DC) have a critical role in modulating angiogenesis and decidualization associated with pregnancy. However, the contribution of these immune cells to the placentation process and subsequently fetal development remains largely elusive. Using two different mouse models, we here show that optimal placentation and fetal development is sensitive to disturbances in NK cell relative abundance at the fetal–maternal interface. Depletion of NK cells during early gestation compromises the placentation process by causing alteration in placental function and structure. Embryos derived from NK-depleted dams suffer from intrauterine growth restriction (IUGR), a phenomenon that continued to be evident in the offspring on post-natal day 4. Further, we demonstrate that IUGR was accompanied by an overall reduction of global DNA methylation levels and epigenetic changes in the methylation of specific hepatic gene promoters. Thus, temporary changes within the NK cell pool during early gestation influence placental development and function, subsequently affecting hepatic gene methylation and fetal metabolism.
Specificity of Stress Signaling Phosphatases in Bacillus subtilis
Creators: name: Penix, Suhaily
Publisher: name: Brandeis University
Year: 2024
Subjects: Bacillus
flap
PPM phosphatases
Specificity
Substrate specificity
switch

description: Both PPM phosphatases and their opposing kinases regulate key cellular events in both eukaryotes and prokaryotes. While kinases have a deep active site groove where their substrates dock, this is not the case for phosphatases. The mechanism behind how PPM phosphatases achieve specificity for their substrates is unknown. Bacillus subtilis only has five PPM phosphatases, making it an ideal system to explore how these phosphatases achieve specificity. RsbU and SpoIIE, are paralogous phosphatases that regulate the general stress response and sporulation in Bacillus subtilis, respectively. They dephosphorylate two structurally similar substrates, RsbV and SpoIIAA, with exquisite specificity. It is critical for these two pathways to avoid crosstalk as activation of σF during vegetative growth is toxic to the cells, and activation of B will halt sporulation. By combining the power of genetics, biochemical approaches, and AlphaFold2 structure predictions, we identified three variable loops at the substrate docking interface on the surface of the PPM phosphatase that recognizes the substrate's three-dimensional structure. These three variable loops are conserved elements that contain non-conserved amino acids that either allow accommodation of the cognate substrate or disfavor accommodation of the non-cognate substrate. When the substrate engages these three variable loops in the phosphatase domain, it docks against the switch, positioning the substrate to organize the catalytic center.
La création de normes en matière de contrôle de l'usage du tabac.
Creators: name: Lorant, Marie-Frédérique.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Health Sciences, Public Health.

description: A ce stade de notre travail, sans revenir en profondeur sur ce qui a deja ete dit, un bref rappel de notre cheminement merite d'etre fait. A l'aide de notre cadre conceptuel nous avons interroge le processus de creation et de modification des arretes municipaux de la ville d'Ottawa portant restriction sur l'usage du tabac dans le lieu de travail et les lieux publics. La question fondamentale qui traverse l'ensemble de ce travail etait de comprendre comment les acteurs sociaux particuliers s'y sont pris pour elaborer les deux By-laws. Nous avons ainsi pu mettre en lumiere la maniere dont le probleme du tabagisme avait ete defini en terme de sante publique, de morale et de facon plus globale en terme d'externalite negative. Dans la solution au probleme, nous nous sommes enquis de savoir comment l'autorite, a partir de la question du non-fumeur, en est venue a legitimer l'appropriation de la gestion du tabagisme par l'Etat. L'analyse du processus decisionnel des appelants a la cause a permis de montrer que la rationalite politique n'avait pas ete absolue mais qu'elle s'etait dotee d'emblee de solutions privilegiees empruntees dans son entourage institutionnel. (Abstract shortened by UMI.)
Late 19th Century German-Jewish Korperkultur and its Philosophical and Aesthetic Sources
Creators: name: Silbert, Ariel
Publisher: name: Brandeis University
Year: 2009
Subjects: 19th Century German Anti-Semitism
19th Century Continental Philosophy
German-Jewish
Korperkultur

description: This thesis examines the philosophical and aesthetic sources informing the emergence of late 19th century German-Jewish Körperkultur, specifically as it was iterated through the gymnastics movement. Our emphasis is upon ideas and iconography relating to the mind and the body, and their socio-political significances. An analysis of 19th century identity, both German and German-Jewish, we examine how the German-Jewish gymnastics movement responded to fin-de-siècle German anti-Semitism. \\tChapter One offers an overview of the key philosophical and aesthetic elements informing the development of a modern German, and German-Jewish, identity. Starting in late 18th century, this chapter considers the impact of Enlightement and post-Enlightenment thought upon German cultural perceptions of Jews and Judaism. We examine the role of Bildung in the formation of a modern German-Jewish iv identity, and consider the impact of a developing German art-historical discourse upon aesthetic perceptions of Jews and Judaism. \\tChapter Two examines how Richard Wagner radicalized, and aestheticized, the anti-Judaic elements present within Enlightenment and post-Enlightenment German thought. We analyze Wagner’s Gesamtkunstwerk, and how Wagner’s notion of performative art in the service of national regeneration informed 19th century völkisch nationalism. Finally, we examine selected works by E. M. Lilien, the first and most famous artist to explicitly tie his artwork to Zionism. These images are analyzed through prism of Wagnerism, in order to determine its relative impact upon Lilien’s vision of Zionism. \\tFinally, Chapter Three will consider the German-Jewish gymnastics movement itself. Specific attention will be paid to the ways in which, during its brief existence, the movement itself struggled with the very issues it sought to resolve. We will also examine how notions of performance and display in the service of nationalism were expressed through athletics. Our discussion will be contextualized through an analysis of fin-de-siècle German anti-Semitism, and how the intersecting discourses of science, medicine and aesthetics reinforced notions of immutable Jewish difference and inferiority vis-à-vis the German. Finally, we will see how these notions impacted German-Jewish gymnasts, and how these socio-cultural developments contributed to the fracturing of the Jüdische Turnerschaft between those committed to remaining German nationalists, and those who chose to embrace Zionism.
UC3a - EMSO-Azores Marine Species Detection Service
Creators: name: Tosello, Vanessa
name: Borremans, Catherine
Publisher: name: Zenodo
Year: 2025
Subjects: EMSO
Buccinidae
Deep Sea Spy
Deep See Species Detection

description: Presentation about the EMSO Azores Service delivered as part of the iMagine webinar series (30/04/2025)
Mutation Detection in Patients with Retinal Dystrophies Using Targeted Next Generation Sequencing
Creators: name: Weisschuh, Nicole
name: Mayer, Anja K.
name: Strom, Tim M.
name: Kohl, Susanne
name: Glöckle, Nicola
name: Schubach, Max
name: Andreasson, Sten
name: Bernd, Antje
name: Birch, David G.
name: Hamel, Christian P.
name: Heckenlively, John R.
name: Jacobson, Samuel G.
name: Kamme, Christina
name: Kellner, Ulrich
name: Kunstmann, Erdmute
name: Maffei, Pietro
name: Reiff, Charlotte M.
name: Rohrschneider, Klaus
name: Rosenberg, Thomas
name: Rudolph, Günther
name: Vámos, Rita
name: Varsányi, Balázs
name: Weleber, Richard G.
name: Wissinger, Bernd
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Retinal dystrophies (RD) constitute a group of blinding diseases that are characterized by clinical variability and pronounced genetic heterogeneity. The different nonsyndromic and syndromic forms of RD can be attributed to mutations in more than 200 genes. Consequently, next generation sequencing (NGS) technologies are among the most promising approaches to identify mutations in RD. We screened a large cohort of patients comprising 89 independent cases and families with various subforms of RD applying different NGS platforms. While mutation screening in 50 cases was performed using a RD gene capture panel, 47 cases were analyzed using whole exome sequencing. One family was analyzed using whole genome sequencing. A detection rate of 61% was achieved including mutations in 34 known and two novel RD genes. A total of 69 distinct mutations were identified, including 39 novel mutations. Notably, genetic findings in several families were not consistent with the initial clinical diagnosis. Clinical reassessment resulted in refinement of the clinical diagnosis in some of these families and confirmed the broad clinical spectrum associated with mutations in RD genes.
Accounting for gender: analysis of Australian bank annual reporting on gender equity at home and in offshore Indonesian subsidiaries
Creators: name: Deakin, Kathrine Colleen
Publisher: name: Swinburne
Year: 2024

description: This study explores how corporate communication supports or detracts from achieving gender equity. Focusing on two Australian banks, Australia and New Zealand Banking Group and the Commonwealth Bank of Australia, as well as their offshore Indonesian subsidiaries, the study analyses the presence, extent and representation of gender equity disclosures over a decade of annual reporting and through a sample of other communication channels such as websites and sustainability reports. The study captures how these banks communicated gender equity as relevant to their operations, variations over time/ between countries, and highlights opportunities to further support gender equity through corporate communication.
title: Supervision & Facilitator Support
Creators: name: Sultan, Mainus
Publisher: name: University of Massachusetts Amherst
Year: 1996
Subjects: subject: International and Comparative Education

description: These manuals were made possible through support from the University Development Linkages Project, Global Bureau, Human Capacity Development Center, U.S. Agency for International Development under the terms of Cooperative Agreement No. DAN-5063-A-00-1108-00.
description: A manual designed for organizations which employ facilitators in different sites and who need to provide them with ongoing supervision and support. The manual provides information and activities which are based on the author’s experience organizing and supervising literacy programs in Bangladesh. The focus of this manual is to help you understand and implement an effective approach towards supervision and facilitator support. The manual provides a framework for exploring the principles of supervision and a series of activities to use in your program. Each activity is a step-by-step guide to help you collect information to design effective in-service training and support systems for the facilitators in your program. By the time you complete the manual, you will have developed a new support system tailored for your program. This manual is intended for literacy and nonformal education practitioners who are responsible for organizing classes and supervising facilitators. the activities can be used to start a new program or improve an existing program. Read the manual and think about how it applies to your work situation. Use the seven activities to create or improve an existing support system for the facilitators with whom you work. At the end of each activity there is a written assignment that asks you to reflect on your experience and write a brief paper. You may also be asked to compile and organize the information you have gathered in lists or charts. These assignments are important because they are part of your personal learning process and will help you develop a deeper understanding of your work in literacy education.
Functional effects of mutations in mumps virus polymerase protein
Creators: name: Nasheri, Neda
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Biology, Microbiology.
subject: Biology, Virology.

description: The Urabe AM9 mumps vaccine was removed from use in many countries due to an unacceptable incidence of post-vaccination disease. The vaccine was found to be a mixture of closely related viruses, presumably with differing degrees of attenuation. One virus isolated from the vaccine has been shown to be fully attenuated in a rodent model. This virus, Gw7, is characterized by growth in Vero cells (titers 2x106 pfu/ml) but extremely limited growth in human cell lines (<104 pfu/ml), while a virulent Urabe virus, 1004, from a patient with post-vaccination meningitis, grows well (>2x107 pfu/ml) in all the cell lines tested to date. Initial sequencing of the genome of the two viruses has identified genetic differences in 6 of the 7 genes, including the two proteins of the replication complex, the polymerase, L (Large protein), and in the P protein (phosphoprotein). The hypothesis was that the amino acid differences observed in L and P play a role in the differences in attenuation in vivo and growth differences in tissue culture cells. The first objective was to confirm the sequence differences in the L and P genes of the viruses and the sequencing results confirmed all the reported differences in the L gene between 1004 and Gw7 plus identified another sequence difference in the L gene which had not been reported in the original sequencing; it also showed that there was no sequence difference in the P gene of the two viruses. The next objective was to compare the polymerase activity of the two viruses. Two methods have been employed to measure the polymerase activity of the viruses; In vivo incorporation of 3H UTP in the presence of Actinomycin D, and transcription of luciferase reporter gene from the Urabe mini-genome construct. For the first assay, the polymerase activity was examined under two different conditions; and in one case, a higher polymerase activity was observed for 1004, but this was not confirmed in the second set of experiments. To compare the polymerase activities of the two viruses with the help of a mini-genome system, the Urabe mini-genome was constructed and the polymerase activity was determined in two ways; using the polymerase complex (L, P and NP proteins) of each virus or the whole viral particles to drive the luciferase expression from the mini-genome. In either case, a significant difference in the polymerase activity of the two viruses was not detected. Thus, it can be concluded that no inherent difference in the polymerase activity between 1004 and Gw7 was observed by the performed experiments in this study.
title: Les Orchidées de La Côte, le 4 juin 2022
title: La Bressonne et la Mérine et leurs falaises de molasse, le 20 juin 2020
titleType: Subtitle
title: Les Orchidées de La Côte, le 4 juin 2022
titleType: AlternativeTitle
Creators: name: Veya, Patrick
Publisher: name: Unknown
Year: 2023

description: C’est sous un soleil radieux et avec une température estivale pour ce début du mois de juin, que 16 personnes se retrouvent au parking de Martinet à 9h30, à proximité de la gare de Nyon pour une excursion dédiée aux orchidées sauvages de La Côte et du Pied du Jura. La floraison ayant au moins deux semaines d’avance par rapport à une année normale, il a fallu composer avec les espèces printanières en fin de floraison ou déjà fanées et les espèces estivales en début de floraison.
DNA dependent RNA polymerase activity of rat heart nuclei during experimentally induced hypertrophy.
Creators: name: Varnai, Katalin.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1970
Subjects: subject: Biology, Molecular.

description: Nuclei from groups of twelve pooled left ventricles of rats were isolated and DNA, RNA and protein contents of the nuclear suspension were determined. RNA polymerase activity was assayed in the presence of either Mg++ or Mn++ and (NH4)2SO4. Electronmicroscopic examination of normal nuclear preparations revealed undamaged nuclei with very little contamination. Cardiac enlargement was produced by constricting the abdominal aorta in experimental animals. The operated animals were sacrificed at different intervals after operation between 4 hours and two weeks The "pure" nuclear suspensions of the myocardium of these animals was isolated for examination. Sham operated animals were used as control up till the third day, after this time normal animal served as control, since the difference between sham operated and normal animal did not persist beyond 3 days. An increase in RNA, DNA and protein content of the nuclear preparation was observed in aortic constricted animals. DNA showed a delayed increase compared to the time course of changes in RNA and protein. RNA polymerase activity showed a biphasic increase following constriction in both Mg ++ and Mn++-(NH4)2SO4 activated systems. In rats killed soon after constriction (4 hours in this study) the Mn++-(NH4)2SO4 system showed the greater percentage increase and on the 3rd-4th day after aortic constriction the increase was considerably greater in the Mg ++ activated system. An increase in RNA polymerase activity as early as 4 hours after aortic constriction was demonstrated in this study, among other findings. This early increase suggests that the stimulation of RNA synthesis - one of the first biochemical events in hypertrophy may play a role in translating the mechanical stress caused by increased outflow resistance into tissue growth.
The association between surrogate marker response measures and the development of opportunistic illnesses in HIV-infected persons enrolled in a large randomized clinical trial.
Creators: name: Kravcik, Stephen.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Health Sciences, Medicine and Surgery.

description: Introduction. Surrogate marker responses are imperfect indicators of response to antiretroviral therapy in HIV. It is proposed that the area under the curve of surrogate marker response will be superior to peak response, or to that measured after a period of therapy. Methods. The database from a study of ritonavir in advanced HIV was used. Using logistic regression, the specificity of the surrogate marker level at baseline, change between baseline and at time points to week 16, peak response, and area under the curve of the response to week 16 and week 40 were determined. The predictive values, likelihood ratios and receiver operating characteristic curves were determined for those of highest specificity. Results. Specificities increased from baseline to week 16. Peak responses were inferior to time period surrogate marker changes, whereas the areas under the curve were comparable or better than the time period surrogate marker changes. The highest specificity at any time point was for the CD4 change at week 8 (55.90%), whereas the highest overall specificity was for the 16 week AUC for the CD4% (69.63%). However, the PPV, NPV, likelihood ratios and ROC curves demonstrated poor performance overall for these surrogate markers. Too few subjects had viral load testing for this marker to be assessed. Discussion. Within the limits of this study, it was demonstrated that the CD4 and CD4% were the surrogate markers most associated with clinical outcome, with the CD4% AUC to 16 weeks having the highest overall specificity and the week 8 CD4 having the greatest specificity for clinical use. However, all surrogate markers had specificities below 70%.
Effets et compatibilité de la combinaison champignons endomycorhiziens et fertilisants chez deux graminées de gazon : Poa pratensis L. cv. Park et Agrostis stolonifera L. cv. Penncross.
Creators: name: Podeszfinski, Catherine Maryse.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Biology, Ecology.

description: The general objective of this thesis was to study the interactions between AM fungi and turfgrass species in the presence of natural or chemical fertilizers. We had hypothesized that this symbiosis is possible, functional and compatible in the presence of fertilizers. To test this hypothesis, we have set three objectives: (i) estimate colonization rate for three AM fungi: Glomus intraradices, G. mosseae and G. aggregatum on two turfgrass species Poa pratensis L. cv Park and Agrostis stolonifera L. cv Penncross; (ii) evaluate the compatibility between natural and chemical fertilizers and AM fungi, and (iii) compare the effects of AM colonization on different physiological parameters in turfgrass. This study was performed over a period of 17 months between June 1996 and October 1997 on two different sites, Clarence Creek and the Central Experimental Farm (Ottawa), respectively low (46ppm) and high (270ppm) in soil phosphorus status. In total, 96 plots were randomly distributed on each sites. To investigate the dynamic of turfgrass community, we performed a greenhouse experiment following the same experimental design as in the field. (Abstract shortened by UMI.)
Community health indicators for Ontario public health units: An evaluation of the Ontario Community Health Profile.
Creators: name: Taylor, Stuart James.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Health Sciences, Public Health.

description: Thee Ontario Community Health Profile was developed in the early 1990s in response to a need for better measurement of community health in the province. This thesis conceptually and empirically evaluates the profile's relevance, representativeness and practicality for measuring community health in Ontario public health units. Based on a review of the literature and various models of community health is defined as more than simply the absence of disease or disability among a collection of individuals. Health must encompass both disabling and enabling characteristics---defined here as measures of negative or positive health---that are related to coping ability. Moreover, community health indicators should encompass levels of measurement that are global and environmental (representing health 'of' the community) as well as aggregate measures (representing health 'in' the community). This paper develops a community health framework---with axes representing the definition of health and the level of community---in order to evaluate indicators according to these two important dimensions. Empirical analyses used data from the HEaLth Planning System (HELPS) data set for Eastern Ontario. (Abstract shortened by UMI.)
In search of indigenous participation in education sector studies in Sub-Saharan Africa.
Creators: name: Meier, Werner G.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Education, Sociology of.

description: In the 1980's, education sector studies emerged as a predominant approach to policy analysis by most donor agencies involved in the identification and design of policy measures for education sector adjustment programs in Sub-Saharan African countries. International donor agencies often used a "technocratic approach" in the conduct of these studies, exercising excessive control and allowing for little indigenous participation in the policy analysis process. Limited indigenous participation in and appropriation of education sector studies became identified as an obstacle to improved education policy implementation. The "participatory approach" to development was soon adopted by some donor agencies as a means to build educational research and policy analysis capacity in Sub-Saharan African countries. This study examined a set of ten donor supported education sector studies undertaken between 1990 and 1994 in Sub-Saharan African countries, determined the extent of indigenous participation and identified the conditionalisites that explain its presence or absence. In general, the research findings indicated that the practice of education sector analysis fell far short of the rhetoric which had embraced the need for increased indigenous participation. Constraints within donor agencies were traced to the administrative procedures and incentives related to project funding and disbursement pressures, while those in Sub-Saharan countries were linked to nascent democratic values and systems of governance, lack of political leadership and a public service life with inter-ministerial conflict and self-interest.
Using scaffolded critiquing tasks to analyze how inorganic chemistry students reason with and about chemical bonding models
Creators: name: Bapu Ramesh, Vinay
Publisher: name: University of Iowa
Year: 2025
Subjects: subject: Chemical Bonding
subject: Chemical Education
subject: Critiquing tasks
subject: Metamodeling
subject: public abstract
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Knowledge of chemical bonds and bonding interactions are key to understanding a myriad of phenomena in chemistry. It is also recognized as a core idea as it acts as an anchor to a wide range of chemical concepts. Most undergraduate curricula present the ideas of bonding through various theories or models such as valence bond theory, molecular orbital theory, crystal field theory, etc. This poses challenges to students as they not only need to have conceptual understanding of these models but also epistemic understanding in order to appropriately use them in various contexts. Prior research has largely focused on documenting students’ misconceptions in chemical bonding. In this study, we focused on how conceptual and epistemic knowledge resources work together as inorganic chemistry students use bonding models to predict and explain chemical behavior. We used semi-structured interviews with scaffolded critiquing tasks to gain insights into students’ thought processes. In order to elicit a range of ideas, participants were sampled from across the chemistry department: (1) undergraduate students in an inorganic chemistry course; (2) undergraduate and graduate students in an advanced inorganic chemistry course; (3) graduate students from the inorganic chemistry division. The knowledge-in-pieces framework acts as our theoretical lens, emphasizing that students’ ideas related to bonding are not large stable, units but are knowledge elements which are sensitive to context and mediated by epistemic resources. We discuss the key findings related to how students reasoned with and about bonding models, focusing on the implications to further research and teaching.
Sumtiem Soon: Temporal Reasoning in the Browser
Creators: name: Shaw, Ryan
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 460807
subject: Information visualisation
classificationCode: 460206
subject: Knowledge representation and reasoning
classificationCode: 430306
subject: Digital history

description: Sumtiem is a browser-based tool for interactively modeling, visualizing and reasoning about relative, partially known, approximate or uncertain temporal extents. It is intended for use with small-to-medium-sized RDF datasets that include descriptions of relations among time intervals.
Tang Xuanzong’s Obsession in Daoism and Yang Guifei’s role in Influencing the Tang Court
Creators: name: Zhuo, Jiajia
Publisher: name: Brandeis University
Year: 2024

description: By looking at and comparing literature reviews and historic records, these narratives overlooked the deep influence that Daoism brought to Tang Xuanzong in Tang Legitimacy, and how Yang Guifei played an important role to in this legitimacy.
D4.4 Open Data Portal
Creators: name: Gonzalez, Esteban
name: Corcho, Oscar
Publisher: name: Zenodo
Year: 2020
Subjects: Data management
data portal
citizen science

description: This deliverable describes the first version of the Data Portal of our project. Our Data Portal not only will be a data repository, it will be a place where we publish all the outputs of our project, including the outputs of our pilots.
 The solution adopted is based on Zenodo and a website developed over Zenodo to access our resources.
Les glissements rétrogressifs de fonte de la rivière Willow, Territoires du Nord-Ouest, Canada: Caractéristiques sédimentologiques, distribution spatiale et temporelle
Creators: name: Bjornson, Jean
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Physical Geography.
subject: Geology.
subject: Environmental Sciences.

description: The Willow River (Richardson Mountains, N.W.T.) drainage basin is located at the western limit reached by the Laurentide ice-sheet during the Last Glacial Maximum (LGM). The icesheet covered the eastern fringe of the Mountains and deposited a lodgment till. The textural maturity and the lithology of the erratics indicate a distant origin to the till. During deglaciation, the retreating ice-sheet provided a supply of melt water to the aggrading permafrost. The resulting ice rich permafrost has been the host to two periods of thermokarst activity. The first, synchronous with the early Holocene warm period, led to an increase in active layer thickness and slope instability. The second, more recent, dates to the Little Ice Age and may have resulted from an increase in either fire frequency or intensity, or in modifications to the vegetation cover. Today, numerous active and inactive retrogressive thaw slumps can be seen throughout the drainage basin, but their distribution is restricted to the LGM. The slumps are polycyclic in nature and their headwall typically expose 2 units: the lodgment till (unit 1) overlain by a diamicton (unit 2) separated by a thaw unconformity. The latter is not associated to the paleo-active layer observed elsewhere in the Canadian northwest. Air photographs show an increase in thermokarst activity during the two last decades.
Synthesis of low-valency neoglycoconjugates using transition metal-catalyzed reactions and synthesis of phenylethanoid glycosides.
Creators: name: Nahra, Joe.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Chemistry, Organic.

description: In the first part of this thesis, a series of rigid glycodimers were synthesized from sugar alkenes and alkynes, using transition metal catalyzed reactions. The synthesis of these dimers depended on the formation of a new carbon-carbon bond between their monomeric units. Sugars containing terminal alkenes were homodimerized using the olefin metathesis reaction, catalyzed by Grubbs' ruthenium catalyst. Terminal alkene carbohydrate derivatives were also coupled with aryl halide carbohydrates by the Heck coupling reaction, using Pd (0) catalyst, to form homo- and hetero-carbohydrate dimers selectively. Glycodimers were also obtained from sugar alkynes, using the Sonogashira coupling reaction. The dimerization of aryl halide carbohydrate derivatives using Pd (0) catalyst, and the cyclotrimerization of alkyne carbohydrates, using Grubbs' catalyst, were also attempted but were not successful. In the second part of this thesis, phenylethanoid glycosides were synthesized by glycosidation reactions. This family of compounds was shown to have numerous biological activities. A multi-step synthesis of Echinacoside, a phenylethanoid glycoside, was attempted.
Seismic responses comparison of RC building in consideration of plastic hinge models and properties
Creators: name: Teruna, D. R.
name: Wijaya, H.
Publisher: name: Swinburne
Year: 2024

description: Assessment of reinforced concrete building capacity under seismic excitation has been recognized to be highly important for the past decades especially in Indonesia. Previous studies showed failures of RC building occurred in columns with bad confinement. The confinement in RC column has significant role in providing ductility and shear capacity for seismic loads. For this aim, a five-story RC building having different confinement on column members are investigated under seismic excitation. Three set of ground motions are selected and matched with target response spectrum of Indonesian code. Nonlinear analysis is performed by utilizing OpenSEES finite element software. To account the inelastic behaviour of beam and column elements, two types of plastic hinge are applied for both elements, namely finite length plastic hinges (plastic zone) and distributed hinges along the length of elements. The results show that there is a noticeable difference in seismic responses in correlation with the building model.
Cultural communication and miscommunication: Chinese MBA students in a Canadian academic and sociocultural context.
Creators: name: Zhang, Senquan.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Education, Bilingual and Multicultural.

description: This doctoral study deals with communication issues of MBA students from China at Eastern Canada University (pseudonym). The author investigates how Chinese cultural presuppositions can lead to miscommunication and misunderstanding in the Canadian academic and social context. The main research questions are: What is the nature of Chinese/Canadian cross-cultural miscommunication and misunderstanding? What are the reasons for such miscommunication and misunderstanding? What are the consequences of such miscommunication and misunderstanding? What are the strategies for dealing/coping with miscommunication and misunderstanding? In examining communication issues in non-instructional, real-life settings, the emphasis of the present study is on communicative competence (Hymes, 1971, 1972) and language socialization (Lazaraton, 1995). Firth & Wagner (1997) lament that although second and foreign language interactions in non-instructional settings are everyday occurrences, such as in the workplace, they have not yet attracted the attention of second language acquisition researchers. The present study addresses this gap. Johnson (1992) encourages ethnographic research, by saying that we can gain new insights by employing ethnographic approaches to understanding second and foreign language learners in schools and varied adult educational and workplace settings. The present study is a naturalistic inquiry employing ethnographic methods; data are collected through (1) observation of the participants, (2) in-depth interviews with key informants, (3) interviews with background informants, and (4) a questionnaire. Data analysis and interpretation follow the qualitative paradigms of phenomenology and hermeneutics (Tesch, 1990). Further, Spindler's (1997) concept of transcultural sensitization has inspired the present study towards a better understanding of the phenomena and concepts involved in learning an additional language and culture. Through its ethnographic approach, the present study shows that cultural factors significantly influenced the Chinese MBA students' sojourn in Canada and played a crucial role in various aspects of their academic work, their off-campus social interaction, their on-campus study-related interaction, and their relationships with Canadians. The present study is expected to contribute to a better understanding of language socialization in cross-cultural contexts and facilitate efficient language and professional training programs. With its emphasis on cross-cultural understanding on the conceptual level, it is further expected to contribute to the theory of language learning and language use in international settings.
Brain, Body, and Behavior in Audiovisual Interaction
Creators: name: Sun, Yile
Publisher: name: Brandeis University
Year: 2021
Subjects: sensory integration
audiovisual

description: Our brain has incredible ability to receive sensory information from multiple modalities, integrate it, and use it to construct a best guess about what's going on around us. However, not every integration is beneficial. Discrepancy in the information carried by different senses may offset or cancel the multisensory benefit. I set out to investigate the costs and benefits of audio-visual integration with a video game platform. In the game, the visual signal is the rhythmic size oscillation of the game target whereas the auditory signal is an amplitude modulated sound that accompanies the oscillation in size. In the game, two species of fish were identical in appearance but differed in the rate at which their size fluctuates.The game requires players to discriminate between the two species of fish. The first study manipulated the coherence of temporal dynamics between the visual and auditory signals and examined the role of temporal coherence on multisensory integration. Study 1 showed a performance advantage rather than a cost associated with temporally matched visual and auditory signals. Study 2 Phase One identified the behavioral and EEG signatures of multisensory integration and found low alpha power and high theta power linked to the audio-visual incongruent condition. The changes seen in alpha and theta power reflects how the brain registers a mismatch between auditory and visual signals. In Study 2 Phase Two, game was modified to incorporate a mild stressor caused by increasingly reduced inter-fish interval, with the maximum allowed response time held constant. In addition to compromised task performance, the negative impact of reducing inter-trial interval was indexed by pulse rate and pulse rate variability. The result suggests perception of time pressure adversely affect the efficacy of cognitive decision making and the ability to adapt to changes. In summary, our brain and body are sensitive to pick up the discrepancies in the signals from different sensory channels. There will be a cost of cognitive flexibility with even the idea of time limitation.
Characterizing African-1-ene Synthase, a Sesquiterpene Synthase
Creators: name: Knotts, Matthew Hunter
Publisher: name: Brandeis University
Year: 2022
Subjects: African-1-ene
African-1-ene Synthase
Sesquiterpene
Sesquiterpene Synthase
Terpene
Terpene Synthase
Natural Products

description: In the world of natural products, terpenes reign as the most diverse category. The natural world has employed terpenes as signaling molecules, antifungals, and pigments while humans have found use for terpenes as biofuels, fragrances, and medicines. Due to the wide-spread prevalence of terpenes, it is useful to understand the enzymes that catalyze their formation, terpene synthases and cyclases. Most interesting about these enzymes are their strategy for carbocation formation and their ability to exhibit promiscuity. A subclass of these enzymes is sesquiterpene synthases, which catalyze the formation of 15-carbon terpene and terpenoid products. Pentalenene Synthase (PS) is a sesquiterpene synthase that makes pentalenene through an anti-Markovnikov mechanism, where it employs residue F76 to stabilize the resulting secondary carbocation on C9 through a π-cation interaction. African-1-ene Synthase (Af-1S) is a novel sesquiterpene synthase that catalyzes the formation of African-1-ene, also likely through an anti-Markovnikov mechanism that forms a secondary carbocation on C9. Unlike PS, however, Af-1S has an alanine rather than a phenylalanine residue at position 76. This calls into question how this enzyme stabilizes its high energy intermediate. Here we develop an effective expression and purification method, assay the protein with FPP, and use AlphaFold2 to infer the structure of the active site of Af-1S. We found that Af-1S makes several sesquiterpene products, suggesting enzymatic promiscuity. We also performed a large-scale assay of Af-1S and FPP to characterize each product with NMR. Finally, when the inferred structure of Af-1S was aligned with PS bound to an inactive substrate analog, we found that Af-1S has no aromatic residues spatially close to C9 of the inactive substrate analog, suggesting that Af-1S must employ some other unidentified stabilizing mechanism.
Classical Education: Origins, Development, and Inadequacies
Creators: name: Arendash, Mary Elizabeth
Publisher: name: Brandeis University
Year: 2023
Subjects: classical education
educational theory
educational tradition
History

description: Classical education, advertised as an alternative to modern public school education, is steadily increasing in popularity across the United States. Its supporters claim that an education in the classical style returns to ancient Greek and Roman theories and traditions. There are, however, numerous problems in the way this educational model is implemented in public charter schools and in private schools, and the connections to historical educational systems are tenuous. In the absence of a clear point in time or a model of ideal ancient education offered by proponents against which to compare, evaluating the accuracy of their claims necessitates an examination of the educational traditions begun in Greece and Rome, their development towards formalized educational systems, and their progression through time and across cultures in Europe and North America. Tracing educational traditions and the eventual origins of the movement indicates that the misappropriation of history and misuse of tradition necessitate significant, fundamental changes to classical education if it is to serve the ultimate goal of providing benefit to students.
International Criminal Justice*: A Global Dream Realized & Paralyzed
Creators: name: Schwartz, Zachary
Publisher: name: Brandeis University
Year: 2019
Subjects: international law
international criminal law
international criminal court
icc
united nations
sixth committee
international institutions
us
ussr
impunity
chapter vii referrals

description: The International Criminal Court (ICC) is designed to be a pivotal international judicial instrument to stem impunity. It has, though, been largely constrained in its ability to accomplish its goals. This study investigated the shortcomings of and complaints against the ICC and the wider field of international criminal justice through historical, data-driven, and theoretical lenses to understand the trends and international power dynamics underlying them. Analysis was separated into three distinct time periods (Eras I, II, and a prospective III), roughly spanning between the end of World War II and the present day. Historical analysis of post-war discussions on the development of permanent instruments for international criminal law and of post-Cold War occurrences in the field reveal a pervasive aversion of major powers to this concept. A data-driven analysis of modern Libya and Syria further evidences such aversion, particularly when the major powers’ interests are threatened. This thesis further argues a change in international power dynamics currently taking place, which further complicates the application of international criminal law. The conclusion points to pervasive trends throughout history and, barring further changes to the extant international order, a bleak future for countering impunity through instruments of international criminal justice.
The effect of non-demineralized dentin matrix components and induced inflammation on dental pulp stem cells
Creators: name: Hogden, Christopher T
Publisher: name: University of Iowa
Year: 2024
Subjects: public abstract

description: Introduction: During the caries process, the secretion of acid metabolites by the microbiome of carious lesions results in the demineralization of dentin. This process liberates dentin matrix components that influence the inflammatory and reparative processes of the dental pulp in response to caries.
description: Methods: Dentin matrix components were extracted from sound, non-carious permanent third molars, purified, and concentrated. Undigested components and components digested by a cocktail of matrix metalloproteinases were used to stimulate third passage dental pulp stem cells alone and in multiple combinations with and without lipopolysaccharide and/or lipoteichoic acid for 24 hours. Cytokine production and gene expression changes were evaluated using LEGENDplex and RNA-sequencing, respectively. Parametric and nonparametric statistical analysis was performed as appropriate to compare differences among multiple groups (α = 0.05).
description: Results: The cytokines CXCL10 (IP-10), CCL2 (MCP-1), IL-6, and CXCL8 (IL-8) were produced by dental pulp stem cells. No differentially expressed genes were detected in pairwise comparisons not involving a bacterial byproduct or matrix metalloproteinases. Variation between dental pulp stem cell donors was significant for differential gene expression.
description: Conclusion: Dental pulp stem cells respond to induced inflammation, matrix metalloproteinases, and dentin matrix components by modifying cytokine production and gene expression. Differences between individuals are a significant factor for variations in gene expression. The modulation of matrix metalloproteinase activity may be valuable for repair of the pulp-dentin complex.