cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
SGLT-2 inhibitors associated euglycemic and hyperglycemic DKA in a multicentric cohort
Creators: name: Ata, Fateen
name: Yousaf, Zohaib
name: Khan, Adeel Ahmad
name: Razok, Almurtada
name: Akram, Jaweria
name: Ali, Elrazi Awadelkarim Hamid
name: Abdalhadi, Ahmed
name: Ibrahim, Diaeldin Abdelgalil
name: Al Mohanadi, Dabia Hamad S. H.
name: Danjuma, Mohammed I.
Publisher: name: Manara - Qatar Research Repository
Year: 2022
Subjects: Medical microbiology

description: Euglycemic diabetic ketoacidosis (EuDKA) secondary to Sodium-glucose co-transporter-2 inhibitors (SGLT2i) in type 2 diabetes mellitus (T2D) is a rare but increasingly reported phenomenon. Not much is known about the burden of EuDKA in patients on SGLT2i or the associated factors. This retrospective cohort study tries to delineate the differences in factors associated with the development of EuDKA as compared to hyperglycemic DKA. We conducted a multicentre, retrospective study across three tertiary care centers under Weill Cornell affiliated-Hamad Medical Corporation, Qatar. The cohort comprised of T2D patients on SGLT2i who developed DKA between January 2015 to December 2020. The differences between the subjects who developed EuDKA or hyperglycaemic DKA (hDKA) were analyzed. A total of 9940 T2D patients were on SGLT2i during 2015–2020, out of which 43 developed DKA (0.43%). 25 developed EuKDA, whereas 18 had hDKA. The point prevalence of EuDKA in our cohort was 58.1%. EuDKA was most common in patients using canagliflozin, followed by empagliflozin and Dapagliflozin (100%, 77%, and 48.3%, respectively). Overall, infection (32.6%) was the most common trigger for DKA, followed by insulin non-compliance (13.7%). Infection was the only risk factor with a significant point estimate between the two groups, being more common in hDKA patients (p-value 0.006, RR 2.53, 95% CI 1.07–5.98). Canagliflozin had the strongest association with the development of EuDKA and was associated with the highest medical intensive care unit (MICU) admission rates (66.6%). In T2D patients on SGLT2i, infection is probably associated with an increased risk of developing EuDKA. The differential role of individual SGLT2i analogs is less clear and will need exploration by more extensive prospective studies.Other Information Published in: Scientific Reports
 License: https://creativecommons.org/licenses/by/4.0
See article on publisher's website: http://dx.doi.org/10.1038/s41598-021-89752-w
Beauvericin potentiates the activity of pesticides by neutralizing the ATP-binding cassette transporters in arthropods
Creators: name: Al Khoury, Charbel
name: Nemer, Nabil
name: Nemer, Georges
Publisher: name: Manara - Qatar Research Repository
Year: 2022
Subjects: subject: Zoology
subject: FOS: Biological sciences

description: Multi-drug resistance is posing major challenges in suppressing the population of pests. Many herbivores develop resistance, causing a prolonged survival after exposure to a previously effective pesticide. Consequently, resistant pests reduce the yield of agricultural production, causing significant economic losses and reducing food security. Therefore, overpowering resistance acquisition of crop pests is a must. The ATP binding cassette transporters (ABC transporters) are considered as the main participants to the pesticide efflux and their neutralization will greatly contribute to potentiate failed treatments. Real-Time PCR analysis of 19 ABC transporter genes belonging to the ABCB, ABCC, ABCG, and ABCH revealed that a broad range of efflux pumps is activated in response to the exposure to pesticides. In this study, we used beauvericin (BEA), a known ABC transporters modulator, to resensitize different strains of Tetranychus urticae after artificial selection for resistance to cyflumetofen, bifenazate, and abamectin. Our results showed that the combinatorial treatment of pesticide (manufacturer’s recommended doses) + BEA (sublethal doses: 0.15 mg/L) significantly suppressed the resistant populations of T. urticae when compared to single-drug treatments. Moreover, after selective pressure for 40 generations, the LC50 values were significantly reduced from 36.5, 44.7, and 94.5 (pesticide) to 8.3, 12.5, and 23.4 (pesticide + BEA) for cyflumetofen, bifenazate, and abamectin, respectively. While the downstream targets for BEA are still elusive, we demonstrated hereby that it synergizes with sub-lethal doses of different pesticides and increases their effect by inhibiting ABC transporters. This is the first report to document such combinatorial activity of BEA against higher invertebrates paving the way for its usage in treating refractory cases of resistance to pesticides. Moreover, we demonstrated, for the first time, using in silico techniques, the higher affinity of BEA to ABC transformers subfamilies when compared to xenobiotics; thus, elucidating the pathway of the mycotoxin.Other Information Published in: Scientific Reports
 License: https://creativecommons.org/licenses/by/4.0
See article on publisher's website: http://dx.doi.org/10.1038/s41598-021-89622-5
Development of Methods for Reducing the Red-Zone in the Top Region of mc-Silicon Ingots
Creators: name: Bähr, T.
name: Ghosh, M.
name: Kranert, C.
name: Reimann, C.
name: Morche, C.
Publisher: name: WIP
Year: 2018
Subjects: Silicon Cells
Feedstock, Crystallisation, Wafering, Defect Engineering

description: 35th European Photovoltaic Solar Energy Conference and Exhibition; 488-492
description: In order to increase the high lifetime volume fraction in multicrystalline-silicon ingots for photovoltaic application by reducing the red-zone at their top, we tested three methods for melt removal from the top of the growing ingot: (1) Absorption by a porous medium, immersed into the melt, (2) vacuum suction of melt via pipes, and (3) pouring of melt by tilting the crucible. The experiments in our G1 lab furnace allowed to compare the different techniques and to identify their specific challenges. However, the final goal could not be reached yet. We hypothesize that an additional contamination via gas phase may be overlaying the positive effect of melt removal.
Joint Computing, Pushing, and Caching Optimization for Mobile Edge Computing Networks via Soft Actor-Critic Learning
Creators: name: Gao, Xiangyu
name: Sun, Yaping
name: Chen, Hao
name: Xu, Xiaodong
name: Cui, Shuguang
Publisher: name: arXiv
Year: 2023
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: Mobile edge computing (MEC) networks bring computing and storage capabilities closer to edge devices, which reduces latency and improves network performance. However, to further reduce transmission and computation costs while satisfying user-perceived quality of experience, a joint optimization in computing, pushing, and caching is needed. In this paper, we formulate the joint-design problem in MEC networks as an infinite-horizon discounted-cost Markov decision process and solve it using a deep reinforcement learning (DRL)-based framework that enables the dynamic orchestration of computing, pushing, and caching. Through the deep networks embedded in the DRL structure, our framework can implicitly predict user future requests and push or cache the appropriate content to effectively enhance system performance. One issue we encountered when considering three functions collectively is the curse of dimensionality for the action space. To address it, we relaxed the discrete action space into a continuous space and then adopted soft actor-critic learning to solve the optimization problem, followed by utilizing a vector quantization method to obtain the desired discrete action. Additionally, an action correction method was proposed to compress the action space further and accelerate the convergence. Our simulations under the setting of a general single-user, single-server MEC network with dynamic transmission link quality demonstrate that the proposed framework effectively decreases transmission bandwidth and computing cost by proactively pushing data on future demand to users and jointly optimizing the three functions. We also conduct extensive parameter tuning analysis, which shows that our approach outperforms the baselines under various parameter settings.
description: 13 pages. arXiv admin note: text overlap with arXiv:2305.12099
From Stoner to Local Moment Magnetism in Atomically Thin Cr2Te3
Creators: name: Zhong, Yong
name: Peng, Cheng
name: Huang, Haili
name: Guan, Dandan
name: Hwang, Jinwoong
name: Hsu, Kuan H.
name: Hu, Yi
name: Jia, Chunjing
name: Moritz, Brian
name: Lu, Donghui
name: Lee, Jun-Sik
name: Jia, Jin-Feng
name: Devereaux, Thomas P.
name: Mo, Sung-Kwan
name: Shen, Zhi-Xun
Publisher: name: arXiv
Year: 2023
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The field of two-dimensional (2D) ferromagnetism has been proliferating over the past few years, with ongoing interests in basic science and potential applications in spintronic technology. However, a high-resolution spectroscopic study of the 2D ferromagnet is still lacking due to the small size and air sensitivity of the exfoliated nanoflakes. Here, we report a thickness-dependent ferromagnetism in epitaxially grown Cr2Te3 thin films and investigate the evolution of the underlying electronic structure by synergistic angle-resolved photoemission spectroscopy, scanning tunneling microscopy, x-ray absorption spectroscopy, and first-principle calculations. A conspicuous ferromagnetic transition from Stoner to Heisenberg-type is directly observed in the atomically thin limit, indicating that dimensionality is a powerful tuning knob to manipulate the novel properties of 2D magnetism. Monolayer Cr2Te3 retains robust ferromagnetism, but with a suppressed Curie temperature, due to the drastic drop in the density of states near the Fermi level. Our results establish atomically thin Cr2Te3 as an excellent platform to explore the dual nature of localized and itinerant ferromagnetism in 2D magnets.
description: 32 pages, 4 + 10 figures
The Impact of Wafer Thickness (210 and 140 Μμm) for Photovoltaic Use on the Fracture Strength
Creators: name: Sekhar, H.
name: Fukuda, T.
name: Tanahashi, K.
name: Takato, H.
Publisher: name: WIP
Year: 2018
Subjects: Silicon Cells
Feedstock, Crystallisation, Wafering, Defect Engineering

description: 35th European Photovoltaic Solar Energy Conference and Exhibition; 503-506
description: We developed a diamond wire characterized by the core steel-wire diameter of 80 μm and the size of diamond abrasives ranging from 6 to 12 μm (labelled as 80d-M6/12). The diamond particles on the wire are designed to have lower density and less agglomeration than those on conventional wires. As-developed diamond wire is introduced into multi wire saw to cut monocrystalline silicon bricks into wafers with a thickness of 210 and 140 μm. The above wire allows us to reduce the silicon dust or kerf to 100 μm per wafer. After as-sawn wafers are separated from fresh and worn-out wire sides of bricks and labelled as fresh and worn-out wire side wafers. In three-line bending test, a variable load is applied in perpendicular direction to wire saw marks on the wafer surface. The fracture strength distributions are evaluated on fresh and worn-out wire side wafers. In thick wafers, the fracture stress distributions are approximately the same on both sides. On the other hand, in thin wafers, the fracture strength is extremely lower than that of thick wafers. And particularly, the strength of fresh wire side wafers is lower compared to that of worn-out wire side wafers. In thin wafers, a small variation in the surface and subsurface damage is a crucial factor to decide their fracture strength of both-side wafers. In case of thick wafers, a small variation in the surface and subsurface damage may not have strong influence on their fracture strength of both-side wafers.
Salt tolerance of selected halophytes at the two initial growth stages for future management options
Creators: name: Alhaddad, Fedae A.
name: Abu-Dieyeh, Mohammed H.
name: ElAzazi, El-Sayed Mohamed
name: Ahmed, Talaat A.
Publisher: name: Manara - Qatar Research Repository
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Scarcity of water and the small area of the agricultural land are considered as the crucial environmental issues challenged the Arabian Gulf countries. In this study, experiments were conducted to identify the salt tolerance during the germination and the seedling stages of some native halophytes in the State of Qatar. Seeds of eight native species (Salsola setifera, Halopeplis perfoliata, Caroxylon imbricatum, Suaeda aegyptiaca, Acacia tortilis, Limonium axillare, Tetraena qatarensis and Aeluropus lagopoides) were investigated. Except for Tetraena qatarensis, Acacia tortilis and Suaeda aegyptiaca, all achieved ≥ 30% of seed germination at a concentration of 200 mM NaCl. Around 30% of Salsola setifera seeds were able to germinate in a salt concentration of 400 mM. Germination recovery of seeds that have been treated with 800 mM NaCl for 3 weeks was the greatest for Halopeplis perfoliata (94%) and the lowest for Aeluropus lagopoides (22%). Five halophytes were investigated for seedling growth under saline irrigation ranged from 0 to 600 mM NaCl. No significant differences obtained in growth biomass of seedlings of each of Caroxylon imbricatum, Suaeda aegyptiaca and Tetraena qatarensis between saline and non-saline treatments.Other Information Published in: Scientific Reports
 License: https://creativecommons.org/licenses/by/4.0
See article on publisher's website: http://dx.doi.org/10.1038/s41598-021-89462-3
Extended Magnetic Exchange Interactions in the High-Temperature Ferromagnet MnBi
Creators: name: Williams, T. J.
name: Taylor, A. E.
name: Christianson, A. D.
name: Hahn, S. E.
name: Fishman, R. S.
name: Parker, D. S.
name: McGuire, M. A.
name: Sales, B. C.
name: Lumsden, M. D.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The high-temperature ferromagnet MnBi continues to receive attention as a candidate to replace rare-earth-containing permanent magnets in applications above room temperature. This is due to a high Curie temperature, large magnetic moments, and a coercivity that increases with temperature. The synthesis of MnBi also allows for crystals that are free of interstitial Mn, enabling more direct access to the key interactions underlying the physical properties of binary Mn-based ferromagnets. In this work, we use inelastic neutron scattering to measure the spin waves of MnBi in order to characterize the magnetic exchange at low temperature. Consistent with the spin reorientation that occurs below 140 K, we do not observe a spin gap in this system above our experimental resolution. A Heisenberg model was fit to the spin wave data in order to characterize the long-range nature of the exchange. It was found that interactions up to sixth nearest neighbor are required to fully parameterize the spin waves. Surprisingly, the nearest-neighbor term is antiferromagnetic, and the realization of a ferromagnetic ground state relies on the more numerous ferromagnetic terms beyond nearest neighbor, suggesting that the ferromagnetic ground state arises as a consequence of the long-ranged interactions in the system.
description: 5 pages, 2 figures, 2 tables; Supplemental Information has 2 pages, 1 figure
Analysis of Infrared Light Trapping on Bifacial Silicon Heterojunction Solar Cells
Creators: name: Gérenton, F.
name: Harrison, S.
name: Carroy, P.
name: Valla, A.
name: Danel, A.
name: Muñoz, D.
Publisher: name: WIP
Year: 2018
Subjects: Silicon Cells
Heterojunction Solar Cells

description: 35th European Photovoltaic Solar Energy Conference and Exhibition; 460-464
description: In silicon heterojunction (SHJ) solar cells, the transparent conductive oxide (TCO) layers used are designed to balance resistive losses and parasitic light absorption. This paper aims to determine the rear TCO optimization that can be made in the case of bifacial SHJ cells, taking into account both optical and electrical aspects. First, internal reflectance in bifacial cells is simulated and characterized for more or less transparent TCO layers, and compared to monofacial cells, in order to establish if the use of a more transparent TCO layer stays beneficial for bifacial cells as well. Then, the internal reflectance is further optimized by tuning the TCO thickness. In this work, we thus show that using a more transparent ITO layer remains an important path of improvement for the internal reflectance in bifacial cells, and that TCO thickness should be optimized differently than for monofacial cells. These results have been confirmed at cell level with a gain in short-circuit current without significant resistive losses observed, resulting in a final efficiency gain. Moreover, this optimization is proved to be also beneficial for the cell’s bifaciality behavior.
A human infertility-associated KASH5 variant promotes mitochondrial localization
Creators: name: Bentebbal, Sana A.
name: Meqbel, Bakhita R.
name: Salter, Anna
name: Allan, Victoria
name: Burke, Brian
name: Horn, Henning F.
Publisher: name: Manara - Qatar Research Repository
Year: 2022
Subjects: Reproductive medicine

description: KASH5 is the most recently identified member of the KASH domain family of tail anchored, outer nuclear membrane (ONM) and endoplasmic reticulum (ER) proteins. During meiosis prophase I, KASH5 and SUN1 form a complex that spans the nuclear envelope and which links the telomeres of meiotic chromosomes to cytoplasmic dynein. This connection is essential for homologous chromosome dynamics and pairing. A recent study identified a variant in human KASH5 (L535Q) that correlated with male infertility associated with azoospermia. However, no molecular mechanism was described. Here, we report that this amino acid substitution, within the KASH5 transmembrane domain (TMD) has no predicted effects on secondary structure. However, the overall hydrophobicity of the L535Q TMD, is calculated to be lower than the wild-type KASH5, based on the GES (Goldman–Engelman–Steitz) amino acid hydrophobicity scale. This change in hydrophobicity profoundly affects the subcellular localization of KASH5. Through a series of amino acid substitution studies, we show that the L535Q substitution perturbs KASH5 localization to the ER and ONM and instead results in mistargeting to the mitochondria membrane. We suggest that this mislocalization accounts for the infertility and azoospermia phenotype in patients.Other Information Published in: Scientific Reports
 License: https://creativecommons.org/licenses/by/4.0
See article on publisher's website: http://dx.doi.org/10.1038/s41598-021-89439-2
Submicrometric Films of Surface-Attached Polymer Network with Temperature-Responsive Properties
Creators: name: Li, Mengxing
name: Bresson, Bruno
name: Cousin, F
name: Fretigny, Christian
name: Tran, Yvette
Publisher: name: arXiv
Year: 2016
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Temperature-responsive properties of surface-attached poly(N-isopropylacrylamide) (PNIPAM) network films with well-controlled chemistry are investigated. The synthesis consists of cross-linking and grafting preformed ene-reactive polymer chains through thiol--ene click chemistry. The formation of surface-attached and cross-linked polymer films has the advantage of being wellcontrolled without any caution of no-oxygen atmosphere or addition of initiators. PNIPAM hydrogel films with same cross-link density are synthesized on a wide range of thickness, from nanometers to micrometers. The swelling-collapse transition with temperature is studied by using ellipsometry, neutron reflectivity, and atomic force microscopy as complementary surface-probing techniques. Sharp and high amplitude temperature-induced phase transition is observed for all submicrometric PNIPAM hydrogel films. For temperature above LCST, surface-attached PNIPAM hydrogels collapse similarly but without complete expulsion of water. For temperature below LCST, the swelling of PNIPAM hydrogels depends on the film thickness. It is shown that the swelling is strongly affected by the surface attachment for ultrathin films below $\sim$150 nm. For thicker films above 150 nm (to micrometers), surface-attached polymer networks with the same cross-link density swell equally. The density profile of the hydrogel films in the direction normal to the substrate is confronted with in-plane topography of the free surface. It results that the free interface width is much larger than the roughness of the hydrogel film, suggesting pendant chains at the free surface.
description: in Langmuir, American Chemical Society, 2015, LANGMUIR, 31 (42), pp.11516-11524
Experimental Signatures and Observational Tests of Universal Mass Evaporation Models
Creators: name: Brown, Benjamin Reed
name: Anthropic AI Assistant
Publisher: name: Zenodo
Year: 2023
Subjects: Astrophysics
Physics
Quantum Mechanics

description: This study proposes and analyzes a range of decisive empirical signatures that could robustly test theoretical models of intrinsic universal exponential quantum gravitational mass evaporation over cosmological timescales as an alternative framework for explaining cosmic expansion.
Additional file 1 of In-between duty and hope for recognition, the experience of physiotherapists working in a university hospital during the COVID-19 first wave in Switzerland: a qualitative study based on focus groups
Creators: name: Pichonnaz, Claude
name: Foley, Rose-Anna
Publisher: name: figshare
Year: 2023
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1.
Effects of Magnesium-Doping on Silicon Leaching for Solar Grade Feedstock Production
Creators: name: Zhu, M.
name: Murgau, A.
name: Safarian, J.
Publisher: name: WIP
Year: 2018
Subjects: Silicon Cells
Feedstock, Crystallisation, Wafering, Defect Engineering

description: 35th European Photovoltaic Solar Energy Conference and Exhibition; 465-468
description: The rapid growth of photovoltaic industry has led to large demands of solar grade silicon (SoG-Si) feedstock production in recent years. Acid leaching as a low-cost and important part of the only available commercial process by the metallurgical route of SoG-Si feedstock production, has accordingly received significant attention. In this work, pure Mg2Si is doped into a commercial metallurgical grade silicon (MG-Si) in molten state, solidified under controlled conditions, and leached by 10% HCl. The effect of Mg doping on the removal of impurities in leaching is studied at different conditions, at 60 ˚C and 80˚C for different leaching durations from 5 minutes up to 1 hour. The results indicate high temperature and long leaching time are in favor of impurities removal. The eutectic Mg2Si phase which contains the silicides of the impurities in association such as Al, Fe, Ca, Ti on the grain boundaries is leached. This causes the purification of silicon and it is shown that P and metallic impurities can be removed in large extents.
Cost Effective Growth of Silicon Mono Ingots by the Application of the Multipulling Technique Combined with Active Crystal Cooling
Creators: name: Mosel, F.
name: Denisov, A.V.
name: Klipp, B.
name: Sennova, N.
name: Herms, M.
name: Kunert, R.
name: Dold, P.
Publisher: name: WIP
Year: 2018
Subjects: Silicon Cells
Feedstock, Crystallisation, Wafering, Defect Engineering

description: 35th European Photovoltaic Solar Energy Conference and Exhibition; 476-482
description: The permanent demand for the improvement of solar cell efficiency and reduction of production costs
has placed much focus on the multiple Cz-pulling techniques from a single crucible. PVA Crystal Growing Systems
GmbH has developed a mobile recharge system for Czochralski pullers, the SiCharger MRS. This system can operate
several Cz-pullers with in a consecutive mode and is characterized by low investment costs, reduced silicon
consumption and higher output per crucible. This system and its potential were presented in detail at the 33rd EU
PVSEC [1]. Another way to save costs due to an increased productivity is a higher pull rate. In order to enable a
higher pull speed under stable crystal growth conditions, the hot zone was investigated and optimized by simulating
the entire crystal growth arrangement with the commercial program package CGSim [2]. As a result, the pull rate
could be increased significantly. In a next approach, an active crystal cooling system was implemented. This cooling
device itself consists of a water cooled container, which is placed above the phase boundary of the growing crystal, in
order to increase the axial temperature gradient in the growing crystal close to its solidification interface. This system
is described in detail in [3]. With this arrangement the heat transport through the crystal is improved so that crystals
with 8 inch diameter were grown with a pull rate of 1.8 mm/min resulting in an appreciable saving of process costs.
Additional file 1 of Effects of changes in trunk inclination on ventilatory efficiency in ARDS patients: quasi-experimental study
Creators: name: Benites, Martín H.
name: Torres, David
name: Poblete, Fabian
name: Labbe, Francisco
name: Bachmann, María C.
name: Regueira, Tomas E.
name: Soto, Leonardo
name: Ferre, Andrés
name: Dreyse, Jorge
name: Retamal, Jaime
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1. The TIDieR reporting guidelines. Methods. Volumetric capnography. Electrical impedance tomography. Security procedure. Figure S1. Enghoff`s index gas exchange. Figure S2. Airway dead space. Figure S3. The slope of phase III (SIII). Table S1. Volumetric capnography. Table S2. Tidal variation of impedance. Figure S4. Ventral and dorsal VTI. Table S3. End-Expiratory lung impedance. Figure S5. Ventral and dorsal EELI. Table S4. Quadrant-based right and left lung analyses using. Figure S6. A Dorsal region of the right lung. B Dorsal region of the left lung. Table S5. Global Inhomogeneity index (GI) analysis.
Short term survival of critically ill COVID-19 Egyptian patients on assisted ventilation treated by either Dexamethasone or Tocilizumab
Creators: name: Rashad, Alaa
name: Mousa, Sherif
name: Nafady-Hego, Hanaa
name: Nafady, Asmaa
name: Elgendy, Hamed
Publisher: name: Manara - Qatar Research Repository
Year: 2022
Subjects: Medical microbiology

description: Tocilizumab (TCZ) and Dexamethasone are used for the treatment of critically ill COVID-19 patients. We compared the short-term survival of critically ill COVID-19 patients treated with either TCZ or Dexamethasone. 109 critically ill COVID-19 patients randomly assigned to either TCZ therapy (46 patients) or pulse Dexamethasone therapy (63 patients). Age, sex, neutrophil/ lymphocyte ratio, D-dimer, ferritin level, and CT chest pattern were comparable between groups. Kaplan–Meier survival analysis showed better survival in Dexamethasone group compared with TCZ (P = 0.002), patients didn’t need vasopressor at admission (P < 0.0001), patients on non-invasive ventilation compared to patients on mechanical ventilation (P<0.0001 ), and in patients with ground glass pattern in CT chest (P<0.0001 ) compared with those who have consolidation. Cox regression analysis showed that, TCZ therapy (HR = 2.162, 95% CI, 1.144–4.087, P <0.0001) compared with Dexamethasone group, higher neutrophil/Lymphocyte ratio (HR = 2.40, CI, 1.351–4.185, P = 0.003), lower PaO2/FiO2, 2 days after treatment, (HR = 1.147, 95% CI, 1.002–1.624, P < 0.0001) independently predicted higher probability of mortality. Dexamethasone showed better survival in severe COVID-19 compared to TCZ. Considering the risk factors mentioned here is crucial when dealing with severe COVID-19 cases. Clinical trial registration No clinicalTrials.gov: Nal protocol approved by Hospital Authorities, for data collection and for participation in CT04519385 (19/08/2020).Other Information Published in: Scientific Reports
 License: https://creativecommons.org/licenses/by/4.0
See article on publisher's website: http://dx.doi.org/10.1038/s41598-021-88086-x
Incommensurate crystal supercell and polarization-flop observed in the magnetoelectric ilmenite, MnTiO3
Creators: name: Silverstein, Harlyn J.
name: Skoropata, Elizabeth
name: Sarte, Paul M.
name: Mauws, Cole
name: Aczel, Adam A.
name: Choi, Eun Sang
name: van Lierop, Johan
name: Wiebe, Christopher R.
name: Zhou, Haidong
Publisher: name: arXiv
Year: 2016
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: MnTiO3 has been studied for many decades, but it was only in the last few years that its strong magnetoelectric behavior had been observed. Here, we use neutron scattering on two separately grown single crystals and two powder samples to show the presence of a supercell that breaks R-3 symmetry. We also present the temperature and field dependence of the dielectric constant and pyroelectric current, and show evidence of non-zero off-diagonal magnetoelectric tensor elements (forbidden by R-3 symmetry) followed by a polarization flop accompanying the spin flop transition at μ0HSF = 6.5 T. Mössbauer spectroscopy on MnTiO3 gently doped with 57Fe was used to help shed light on the impact of the supercell on the observed behavior. Although the full supercell structure could not be solved at this time due to a lack of visible reflections, the full-scope of the results presented here suggest that the role of local spin-lattice coupling in the magnetoelectric properties of MnTiO3 is likely more important than previously thought.
description: 20 pages, 5 figures, accepted for publication in Physical Review B
Phosphorus Removal from Al-Doped Silicon by Vacuum Refining
Creators: name: Hoseinpur, A.
name: Safarian, J.
Publisher: name: WIP
Year: 2018
Subjects: Silicon Cells
Feedstock, Crystallisation, Wafering, Defect Engineering

description: 35th European Photovoltaic Solar Energy Conference and Exhibition; 469-472
description: In production of solar grade silicon (SoG-Si), it is necessary to remove phosphorus (P) from Si to make the solar cells with proper efficiency. However, P is one of the most problematic elements to be removed from Si and cannot be removed by directional solidification because of its high segregation coefficient. Vacuum refining can be used as an effective method to remove P from Si due to the much higher vapor pressure of P than Si. In this research, the effect of Al addition on the P removal from a commercial Si is studied under controlled vacuum pressures. After refining process, the alloy is characterized by ICP-MS technique. Results show that P is removed from Si with higher rates when Al is added to the melt. In addition, it is seen that Al was removed from the Si considerably in the vacuum refining process.
Schmidt, Margarethe (unter Mitarbeit von Monika Heffels): Warum ein Apfel, Eva?
Creators: name: Junker, Thomas
Publisher: name: Lutherische Beiträge
Year: 1970

description: Lutherische Beiträge, Bd. 7 Nr. 2 (2002): Lutherische Beiträge, Band 7, Heft 2
Spectral evolution of flaring blazars from numerical simulations
Creators: name: Fromm, C. M.
name: Perucho, M.
name: Mimica, P.
name: Ros, E.
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: High resolution Very Long Baseline Interferometry (VLBI) observations of Active Galactic Nuclei (AGN) revealed traveling and stationary or quasi-stationary radio-components in several blazar jets. The traveling ones are in general interpreted as shock waves generated by pressure perturbations injected at the jet nozzle. The stationary features can be interpreted as recollimation shocks in non-pressure matched jets if they show a quasi-symmetric bump in the spectral index distribution. In some jets there may be interactions between the two kinds of shocks. These shock--shock interactions are observable with VLBI techniques, and their signature should also be imprinted on the single--dish light curves. We performed relativistic hydrodynamic (RHD) simulations of over-pressured and pressure-matched jets. To simulate the shock interaction we injected a perturbation at the jet nozzle once a steady-state was reached. We computed the non-thermal emission (including adiabatic and synchotron losses) resulting from the simulation. We show that the injection of perturbations in a jet can produce a bump in emission at GHz frequencies previous to the main flare, which is produced when the perturbation fills the jet in the observer's frame. The detailed analysis of our simulations and the non-thermal emission calculations show that interaction between a recollimation shock and traveling shock produce a typical and clear signature in both the single--dish light curves and in the VLBI observations: the flaring peaks are higher and delayed with respect to the evolution of a perturbation through a conical jet. This fact can allow to detect such interactions for stationary components lying outside of the region in where the losses are dominated by inverse Compton scattering.
description: 15 pages, 17 figures
SIRT1 promotes lipid metabolism and mitochondrial biogenesis in adipocytes and coordinates adipogenesis by targeting key enzymatic pathways
Creators: name: Majeed, Yasser
name: Halabi, Najeeb
name: Madani, Aisha Y.
name: Engelke, Rudolf
name: Bhagwat, Aditya M.
name: Abdesselem, Houari
name: Agha, Maha V.
name: Vakayil, Muneera
name: Courjaret, Raphael
name: Goswami, Neha
name: Hamidane, Hisham Ben
name: Elrayess, Mohamed A.
name: Rafii, Arash
name: Graumann, Johannes
name: Schmidt, Frank
name: Mazloum, Nayef A.
Publisher: name: Manara - Qatar Research Repository
Year: 2022
Subjects: Medical microbiology

description: The NAD+-dependent deacetylase SIRT1 controls key metabolic functions by deacetylating target proteins and strategies that promote SIRT1 function such as SIRT1 overexpression or NAD+ boosters alleviate metabolic complications. We previously reported that SIRT1-depletion in 3T3-L1 preadipocytes led to C-Myc activation, adipocyte hyperplasia, and dysregulated adipocyte metabolism. Here, we characterized SIRT1-depleted adipocytes by quantitative mass spectrometry-based proteomics, gene-expression and biochemical analyses, and mitochondrial studies. We found that SIRT1 promoted mitochondrial biogenesis and respiration in adipocytes and expression of molecules like leptin, adiponectin, matrix metalloproteinases, lipocalin 2, and thyroid responsive protein was SIRT1-dependent. Independent validation of the proteomics dataset uncovered SIRT1-dependence of SREBF1c and PPARα signaling in adipocytes. SIRT1 promoted nicotinamide mononucleotide acetyltransferase 2 (NMNAT2) expression during 3T3-L1 differentiation and constitutively repressed NMNAT1 and 3 levels. Supplementing preadipocytes with the NAD+ booster nicotinamide mononucleotide (NMN) during differentiation increased expression levels of leptin, SIRT1, and PGC-1α and its transcriptional targets, and reduced levels of pro-fibrotic collagens (Col6A1 and Col6A3) in a SIRT1-dependent manner. Investigating the metabolic impact of the functional interaction of SIRT1 with SREBF1c and PPARα and insights into how NAD+ metabolism modulates adipocyte function could potentially lead to new avenues in developing therapeutics for obesity complications.Other Information Published in: Scientific Reports
 License: https://creativecommons.org/licenses/by/4.0
See article on publisher's website: http://dx.doi.org/10.1038/s41598-021-87759-x
On sector magnets or transverse electromagnetic fields in cylindrical coordinates
Creators: name: Zolkin, Timofey
Publisher: name: arXiv
Year: 2016
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: The Laplace's equations for the scalar and vector potentials describing electric or magnetic fields in cylindrical coordinates with translational invariance along azimuthal coordinate are considered. The series of special functions which, when expanded in power series in radial and vertical coordinates, in lowest order replicate the harmonic homogeneous polynomials of two variables are found. These functions are based on radial harmonics found by Edwin~M.~McMillan in his more-than-40-years "forgotten" article, which will be discussed. In addition to McMillan's harmonics, second family of adjoint radial harmonics is introduced, in order to provide symmetric description between electric and magnetic fields and to describe fields and potentials in terms of same special functions. Formulas to relate any transverse fields specified by the coefficients in the power series expansion in radial or vertical planes in cylindrical coordinates with the set of new functions are provided. This result is no doubt important for potential theory while also critical for theoretical studies, design and proper modeling of sector dipoles, combined function dipoles and any general sector element for accelerator physics. All results are presented in connection with these problems.
General lepton textures and their implications
Creators: name: Ahuja, Gulsheen
name: Sharma, Samandeep
name: Fakay, Priyanka
name: Gupta, Manmohan
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The present work attempts to provide an overview of texture specific lepton mass matrices. In particular, we summarize the findings of some recent analyses carried out within non flavor basis, wherein a parallel texture structure for the lepton and neutrino mass matrices is considered.
description: 9 pages
Clinical utility of ANA-ELISA vs ANA-immunofluorescence in connective tissue diseases
Creators: name: Alsaed, Omar Suhail
name: Alamlih, Laith Ishaq
name: Al-Radideh, Omar
name: Chandra, Prem
name: Alemadi, Samar
name: Al-Allaf, Abdul-Wahab
Publisher: name: Manara - Qatar Research Repository
Year: 2022
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: We investigated the performance of ANA-ELISA for CTDs screening and diagnosis and comparing it to the conventional ANA-IIF. ANA-ELISA is a solid-phase immune assay includes 17 ANA-targeted recombinant antigens; dsDNA, Sm-D, Rib-P, PCNA, U1-RNP (70, A, C), SS-A/Ro (52 and 60), SS-B/La, Centromere B, Scl-70, Fibrillarin, RNA Polymerase III, Jo-1, Mi-2, and PM-Scl. During the period between March till December 2016 all requests for ANA from primary, secondary, and tertiary care centers were processed with both techniques; ANA-IIF and ANA-ELISA. The electronic medical record of these patients was reviewed looking for CTD diagnosis documented by the Senior rheumatologist. SPSS 22 is used for analysis. Between March and December 2016, a total of 12,439 ANA tests were requested. 1457 patients were assessed by the rheumatologist and included in the analysis. At a cut-off ratio ≥ 1.0 for ANA-ELISA and a dilutional titre ≥ 1:80 for ANA-IIF, the sensitivity of ANA-IIF and ANA-ELISA for all CTDs were 63.3% vs 74.8% respectively. For the SLE it was 64.3% vs 76.9%, Sjogren’s Syndrome was 50% vs 76.9% respectively. The overall specificity of ANA-ELISA was 89.05%, which was slightly better than ANA-IIF 86.72%. The clinical performance of ANA-ELISA for CTDs screening showed better sensitivity and specificity as compared to the conventional ANA-IIF in our cohort.Other Information Published in: Scientific Reports
 License: https://creativecommons.org/licenses/by/4.0
See article on publisher's website: http://dx.doi.org/10.1038/s41598-021-87366-w
Mathematical Modeling of Electromagnetic Stirring of Silicon Melt
Creators: name: Karabanov, S.M.
name: Suvorov, D.V.
name: Tarabrin, D.Y.
name: Karabanov, A.S.
name: Slivkin, E.V.
name: Trubitzin, A.A.
name: Belyakov, O.A.
Publisher: name: WIP
Year: 2018
Subjects: Silicon Cells
Feedstock, Crystallisation, Wafering, Defect Engineering

description: 35th European Photovoltaic Solar Energy Conference and Exhibition; 483-487
description: The purpose of the work is the mathematical modeling of electromagnetic stirring of silicon melt using
COMSOL Multiphysics software. In the calculations, the silicon stirring under the action of a traveling magnetic field
are considered for 2D and 3D models. Using the model, distributions of the Lorentz force in silicon melt and the
velocity fields of the melt movement under various conditions of electromagnetic stirring are obtained. The
interrelation between electromagnetic stirring parameters and the rate of surface mass transfer is established.
Mechanical Bounds to Transcriptional Noise
Creators: name: Sevier, Stuart A.
name: Kessler, David A.
name: Levine, Herbert
Publisher: name: arXiv
Year: 2016
Subjects: subject: Subcellular Processes (q-bio.SC)
subject: FOS: Biological sciences

description: Over the last several decades it has been increasingly recognized that stochastic processes play a central role in transcription. Though many stochastic effects have been explained, the source of transcriptional bursting (one of the most well-known sources of stochasticity) has continued to evade understanding. Recent results have pointed to mechanical feedback as the source of transcriptional bursting but a reconciliation of this perspective with preexisting views of transcriptional regulation is lacking. In this letter we present a simple phenomenological model which is able to incorporate the traditional view of gene expression within a framework with mechanical limits to transcription. Our model explains the emergence of universal properties of gene expression, wherein the lower limit of intrinsic noise necessarily rises with mean expression level.
Performance of Modules and Solar Cells Made of 100% Solar Silicon Purified by Direct Route
Creators: name: Forniés, E.
name: Souto, A.
name: Vlasenko, T.
name: Pérez Vázquez, A.
name: Tojeiro, M.
name: Anoshenko, M.
name: Varela, G.
Publisher: name: WIP
Year: 2018
Subjects: Silicon Cells
Feedstock, Crystallisation, Wafering, Defect Engineering

description: 35th European Photovoltaic Solar Energy Conference and Exhibition; 473-475
description: After several years of research, FerroSolar has designed a novel but mature process that is able to purify the metallurgical grade silicon (MeG-Si) from 2 nines up to 6 nines of purity. An important step forward has been the capability of the process to reduce the phosphorous and boron concentration down to a level where compensation is enough to obtain a resistivity within the standard parameters of solar cell producers ( = 1-3 Ω·cm). This resistivity has been achieved with furnace charges of 100% solar silicon (or UMG). This paper describes the process followed by the solar silicon along the whole value chain, showing the outcomes in each step. MeG silicon has been purified in a multi-step process that involves, the usage of slags and vacuum purification, obtaining the solar grade silicon. Then multi-crystalline ingots were grown by high performance multi process (HPM). The wafers were sent to a solar cell and module producer where underwent through and standard process of manufacturing according to Al-BSF technology. Solar cells of up to 18.84% efficiency and modules of up to 333 W were obtained. This performance is particularly high, considering that no high efficiency technologies have been applied to the cell manufacturing.
Synthesis and characterization of Mg–Zn ferrite based flexible microwave composites and its application as SNG metamaterial
Creators: name: Rahman, Md Atiqur
name: Islam, Mohammad Tariqul
name: Singh, Mandeep Singh Jit
name: Samsuzzaman, Md
name: Chowdhury, Muhammad E. H.
Publisher: name: Manara - Qatar Research Repository
Year: 2022
Subjects: subject: Materials engineering
subject: FOS: Materials engineering

description: In this article, we propose SNG (single negative) metamaterial fabricated on Mg–Zn ferrite-based flexible microwave composites. Firstly, the flexible composites are synthesized by the sol-gel method having four different molecular compositions of MgxZn(1−x)Fe2O4, which are denoted as Mg20, Mg40, Mg60, and Mg80. The structural, morphological, and microwave properties of the synthesized flexible composites are analyzed using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and conventional dielectric assessment kit (DAK) to justify their possible application as dielectric substrate at microwave frequency regime. Thus the average grain size is found from 20 to 24 nm, and the dielectric constants are 6.01, 5.10, 4.19, and 3.28, as well as loss tangents, are 0.002, 0.004, 0.006, and 0.008 for the prepared Mg–Zn ferrites, i.e., Mg20, Mg40, Mg60, and Mg80 respectively. Besides, the prepared low-cost Mg–Zn ferrite composites exhibit high flexibility and lightweight, which makes them a potential candidate as a metamaterial substrate. Furthermore, a single negative (SNG) metamaterial unit cell is fabricated on the prepared, flexible microwave composites, and their essential electromagnetic behaviors are observed. Very good effective medium ratios (EMR) vales are obtained from 14.65 to 18.47, which ensure the compactness of the fabricated prototypes with a physical dimension of 8 × 6.5 mm2. Also, the proposed materials have shown better performances comparing with conventional FR4 and RO4533 materials, and they have covered S-, C-, X-, Ku-, and K-band of microwave frequency region. Thus, the prepared, flexible SNG metamaterials on MgxZn(1−x)Fe2O4 composites are suitable for microwave and flexible technologies.Other Information Published in: Scientific Reports
 License: https://creativecommons.org/licenses/by/4.0
See article on publisher's website: http://dx.doi.org/10.1038/s41598-021-87100-6
Resonant capture of multiple planet systems under dissipation and stable orbital configurations
Creators: name: Voyatzis, George
Publisher: name: arXiv
Year: 2016
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Migration of planetary systems caused by the action of dissipative forces may lead the planets to be trapped in a resonance. In this work we study the conditions and the dynamics of such resonant trapping. Particularly, we are interested in finding out whether resonant capture ends up in a long-term stable planetary configuration. For two planet systems we associate the evolution of migration with the existence of families of periodic orbits in the phase space of the three-body problem. The family of circular periodic orbits exhibits a gap at the 2:1 resonance and an instability and bifurcation at the 3:1 resonance. These properties explain the high probability of 2:1 and 3:1 resonant capture at low eccentricities. Furthermore, we study the resonant capture of three-planet systems. We show that such a resonant capture is possible and can occur under particular conditions. Then, from the migration path of the system, stable three-planet configurations, either symmetric or asymmetric, can be determined.
description: 10 ages, 13 figures, 5th Ph.D. School on Mathematical Modeling for Complex Systems