cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Professional practicum: Conceptions of an effective early childhood environment
Creators: name: Zielke, Karen
Publisher: name: CQUniversity
Year: 2022
Subjects: subject: 130102 Early Childhood Education (excl. Maori)
subject: FOS: Educational sciences
subject: 130399 Specialist Studies in Education not elsewhere classified

description: Within the last decade, there have been significant changes to the field of early childhood care and education, both in the perceived role of early childhood programs and in the types of services that are available to young children and their families. For many service users and providers, the ideal or most effective environment for young children may vary considerably. This study was conducted in order to attempt to reach a clearer understanding of the phenomenon of an effective early childhood environment. More specifically, this study centres around gathering service users' conceptions of what constitutes an effective early childhood environment for young children. A phenomenographic approach was utilised, with several service users being interviewed during this study, in order to identify and characterise the different ways in which they conceptualise the phenomenon of an effective early childhood environment. This work provided a valuable learning experience in the use of phenomenoeraphic methodology.
Musher_et_al_Tityrinae_Elect_supp_material.pdf from Why is Amazonia a ‘source’ of biodiversity? Climate-mediated dispersal and synchronous speciation across the Andes in an avian group (Tityrinae).
Creators: name: Musher, Lukas J.
name: Ferreira, Mateus
name: Auerbach, Anya L.
name: McKay, Jessica
name: Cracraft, Joel
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Molecular Biology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60301 Animal Systematics and Taxonomy
subject: 60310 Plant Systematics and Taxonomy

description: Here we present our supplementary methods for genetic locus filtering, scoring of taxa for ancestral ecological analyses, some phylogenomic methods, macroevolutionary analyses, and additional discussion of biogeographic history.
(400863) Catherine Ramsay
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Graphene-Silicon Layered Structures on Single-crystalline Ir(111) Thin Films
Creators: name: Que, Yande
name: Zhang, Yong
name: Wang, Yeliang
name: Huang, Li
name: Xu, Wenyan
name: Tao, Jing
name: Wu, Lijun
name: Zhu, Yimei
name: Kim, Kisslinger
name: Weinl, Michael
name: Schreck, Matthias
name: Shen, Chengmin
name: Du, Shixuan
name: Liu, Yunqi
name: Gao, H. -J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Single-crystalline transition metal films are ideal playing fields for the epitaxial growth of graphene and graphene-base materials. Graphene-silicon layered structures were successfully constructed on Ir(111) thin film on Si substrate with an yttria-stabilized zirconia buffer layer via intercalation approach. Such hetero-layered structures are compatible with current Si-based microelectronic technique, showing high promise for applications in future micro- and nano-electronic devices.
description: 14 pages, 6 figures
Infraciliature et morphométrie de cinq espèces de ciliés mésopsammiques méditerranéens
Creators: name: DRAGESCO, Jean
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1996

description: Infraciliation and morphometry of five species of mesopsammic mediteranean ciliates. Five species of interstitial ciliates, collected on the beaches of fine sand in the Sète area, France, have been studied thanks to an improvement of the fixation and protargol impregnation technics, in order to specify their morphology and to detail their infraciliature with the aid of morphometric methods. These species are: Trachelolophos setensis n. sp., third species of a new genus, described in 1996, Paraclathrostoma gigas n. sp., second species of the genus, Condylostoma longicaudata n. sp., compared to the others species provided with a caudal tip, Metopus contortus redescribed with more details and Blepharisma parasalinarum n. sp. which is compared with various morphotypes of Anigstenia salinarum.
JQ1 suppresses tumor growth through downregulating LDHA  in ovarian cancer
Creators: name: Qiu, Haifeng
name: Bae-Jump, Victoria L.
name: Jackson, Amanda L.
name: Zhou, Chunxiao
name: Zhong, Yan
name: Chan, Leo Li Ying
name: Kilgore, Joshua E.
name: Gehrig, Paola A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Amplification and overexpression of c-Myc is commonly seen in human ovarian cancers, and this could be a potentially novel therapeutic target for this disease. JQ1, a selective small-molecule BET bromodomain (BRDs) inhibitor, has been found to suppress tumor progression in several cancer cell types. Using ovarian cancer cell lines, a transgenic mouse model, and primary cell cultures from human ovarian cancer tissues, we demonstrated that JQ1 significantly suppressed cellular proliferation and induced cell cycle arrest and apoptosis in ovarian cancer cells and mouse model via targeting c-Myc. In addition, JQ1 had multiple influences on cancer metabolism, particularly in the aerobic glycolysis pathway. JQ1 reduced both the activity and phosphorylation of LDHA, inhibited lactate production, and decreased the energy supply to ovarian cancer cell lines and tumors. Taken together, our findings suggest that JQ1 is an efficacious anti-tumor agent in ovarian cancer that is associated with cell cycle arrest, induction of apoptosis and alterations of metabolism.
Population structure of the traditionally exploited holothurian Holothuria tubulosa in the south Aegean Sea
Creators: name: ANTONIADOU, Chryssanthi
name: VAFIDIS, Dimitris
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2011

description: Population structure of the traditionally exploited holothurian, Holothuria tubulosa, was studied in the south Aegean Sea for two consecutive years. Conspicuous populations of the species were detected at four of the eight surveyed islands, with a mean abundance, estimated through fishing effort, at 75 ± 101 ind.h-1 dive. Size-frequency distributions were unimodal at each surveyed island that hosted conspicuous populations. Holothurians mean size and gonad index had smaller values at Pserimos Island, while the relevant temporal differences were not significant. The oligotrophic status of the Dodecanese complex combined with the effect of uncontrolled fishery may explain the observed results.
(400862) Robert Myles
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Musher_et_al_Tityrinae_Elect_supp_material.pdf from Why is Amazonia a ‘source’ of biodiversity? Climate-mediated dispersal and synchronous speciation across the Andes in an avian group (Tityrinae)
Creators: name: Musher, Lukas J.
name: Ferreira, Mateus
name: Auerbach, Anya L.
name: McKay, Jessica
name: Cracraft, Joel
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Molecular Biology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60301 Animal Systematics and Taxonomy
subject: 60310 Plant Systematics and Taxonomy

description: Here we present our supplementary methods for genetic locus filtering, scoring of taxa for ancestral ecological analyses, some phylogenomic methods, macroevolutionary analyses, and additional discussion of biogeographic history.
Lowered circulating aspartate is a metabolic feature of human breast cancer
Creators: name: Qiu, Yunping
name: Zhou, Bingsen
name: Jia, Wei
name: Yu, Herbert
name: Yen, Yun
name: Zhao, Xueqing
name: Garmire, Lana
name: Zhao, Aihua
name: Shvetsov, Yurii B.
name: Xie, Guoxiang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Distinct metabolic transformation is essential for cancer cells to sustain a high rate of proliferation and resist cell death signals. Such a metabolic transformation results in unique cellular metabolic phenotypes that are often reflected by distinct metabolite signatures in tumor tissues as well as circulating blood. Using a metabolomics platform, we find that breast cancer is associated with significantly (p = 6.27E-13) lowered plasma aspartate levels in a training group comprising 35 breast cancer patients and 35 controls. The result was validated with 103 plasma samples and 183 serum samples of two groups of primary breast cancer patients. Such a lowered aspartate level is specific to breast cancer as it has shown 0% sensitivity in serum from gastric (n = 114) and colorectal (n = 101) cancer patients. There was a significantly higher level of aspartate in breast cancer tissues (n = 20) than in adjacent non-tumor tissues, and in MCF-7 breast cancer cell line than in MCF-10A cell lines, suggesting that the depleted level of aspartate in blood of breast cancer patients is due to increased tumor aspartate utilization. Together, these findings suggest that lowed circulating aspartate is a key metabolic feature of human breast cancer.
BioClocks UK Newsletter 2nd Edition
Creators: name: BioClocks UK
name: Dodd, Antony
name: Foster, Russell
name: Rzechorzek, Nina
name: Stevenson, Tyler
name: Jones, Matt
name: Bafna, Akanksha
name: Ronald, James
name: Jabbur, Luísa
name: Rees, Hannah
name: Wilcockson, David
name: Rosen, Lorena
Publisher: name: Zenodo
Year: 2024

description: BioClocksUK Newsletter 1st Edition

Edited by Prof. Antony Dodd

Compiled by Ms. Lorena Rosen

BioClocksUK graphics by Dr. Nina Rzechorzek

Authors: Prof. Antony Dodd, Prof. Russell Foster, Prof. Tyler Stevenson, Dr. Matt Jones, Dr. Akanksha Bafna, Dr. James Ronald, Dr. Luísa Jabbur, Dr. Hannah Rees, Dr. David Wilcockson, Dr. Nina Rzechorzek and Ms. Lorena Rosen.

Special acknowledgment to all contributors and to the BioClocksUK volunteers.

Funders: The Royal Society of Edinburgh and The Biotechnology and Biological Sciences Research Council
Path-space variational inference for non-equilibrium coarse-grained systems
Creators: name: Harmandaris, Vagelis
name: Kalligiannaki, Evangelia
name: Katsoulakis, Markos A.
name: Plecháč, Petr
Publisher: name: arXiv
Year: 2015
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 65C05, 65C20, 82C22, 82C20

description: In this paper, we discuss information-theoretic tools for obtaining optimized coarse-grained molecular models for both equilibrium and non-equilibrium molecular dynamics. The latter are ubiquitous in physicochemical and biological applications, where they are typically associated with coupling mechanisms, multi-physics and/or boundary conditions. In general the non-equilibrium steady states are not known explicitly as they do not necessarily have a Gibbs structure. The presented approach can compare microscopic behavior of molecular systems to parametric and non-parametric coarse-grained one using the relative entropy between distributions on the path space and setting up a corresponding path space variational inference problem. The methods can become entirely data-driven when the microscopic dynamics are replaced with corresponding correlated data in the form of time series. Furthermore, we present connections and generalizations of force matching methods in coarse-graining with path-space information methods, as well as demonstrate the enhanced transferability of information-based parameterizations to general observables due to information inequalities. We further discuss methodological connections between information-based coarse-graining of molecular systems and variational inference methods primarily developed in the machine learning community. However, we note that the work presented here addresses variational inference for correlated time series due to the focus on dynamics. The applicability of the proposed methods is demonstrated on high-dimensional stochastic processes given by Langevin, overdamped and driven Langevin dynamics of interacting particles.
title: Spontaneous spinal epidural hematoma in a 34-weeks primigravida
Creators: name: PANDA, SOURAV
Publisher: name: EURORAD
Year: 2023
Subjects: subject: Neuroradiology
subject: CNS
subject: MR
subject: CNS
subject: Obstetrics
subject: Clinical Cases

description: Clinical History: A 25-year-old lady with 34 weeks of gestation (G1P0A0L0) presented to our hospital with a history of neck pain for 3 days and sudden onset weakness in all four limbs. On neurological examination, she had quadriplegia with sensory loss below the neck along with loss of bowel and bladder control. She had no history of any constitutional symptoms.

description: 25 years, female
Reproductive cycle and life history traits of the grass goby, Zosterisessor ophiocephalus (Gobiidae), in the Gulf of Gabes (Central Mediterranean)
Creators: name: HAJJI, Ferid
name: OUANNES-GHORBEL, Amira
name: GHORBEL, Mohamed
name: JARBOUI, Othman
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2011

description: The grass goby, Zosterisessor ophiocephalus (Pallas, 1811), in the Gulf of Gabes (southeast of Tunisia) is a gonochoric species that belongs to the Gobiidae family. Z. ophiocephalus was sampled monthly between September 2006 and August 2007 involving 1096 specimens. Length distribution varied between 7.5 and 17.5 cm standard length. Over the entire population, the sex ratio was unbalanced, with females dominated among smaller individuals (standard length SL < 11 cm) and males were predominant in larger size-classes (SL > 11 cm). Monthly changes of the Gonad-Somatic Index (GSI) showed that reproduction period occurs from January to May, with a maximum in March and April and spawning occurs in (April-May). The variation of the GSI for Z. ophiocephalus males in the Gulf of Gabes show a lower values of the GSI and during the reproductive season, small males showing an important GSI value. Concerning females the GSI
 distribution is perfectly independent of the size. To get ready for reproduction and to develop its gonads Z. ophiocephalus saves lipid reserves in muscles as well as in liver. Monthly changes of the Seminal Vesicle Somatic Index (SVSI) showed that during the pre-spawning period they have a proliferation phase, followed by a regressive phase during the post-spawning period. Concerning the first sexual maturity it was noted that the main size related to 50% of matured individuals
 were for males: 11.25 ± 0.12 cm and for females: 10.21 ± 0.24 cm of the standard length (SL).
Competitive interfacial charge transfer to graphene from the electrode contacts and surface adsorbates
Creators: name: Nouchi, Ryo
name: Tanigaki, Katsumi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Charge transfer (CT) at metal-graphene contacts induces a potential variation from the contact edges that extends to ~1 micrometer. Potential variations with a similar length should be observed around charge-transferring surface adsorbates. Thus, it is expected that a competition exists between these two CT sources when one source is within ~1 micrometer from the other. In this letter, weakly-coupled Ni contacts and 7,7,8,8-tetracyanoquinodimethan molecules are employed as the CT sources to investigate their possible competition. The CT from the molecules adsorbed only in the channel region change the charge density of the graphene in the under-contact regions. The extent of the CT effect in the under-contact region is as long as ~4 micrometers. The considerably long CT is ascribed to the high effective dielectric constant of the graphene under the contacts, resulting from a thin interfacial NiOx layer containing carbon impurities acquired from the graphene.
description: 13 pages, 4 figures
Suprabenthic community of the Cananeia lagoon estuarine region, Southeastern Brazil
Creators: name: TARARAM, Airton Santo
name: WAKABARA, Yoko
name: FLYNN, Maurea Nicoletti
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1996

description: The temporal and spatial distribution of the suprabenthos in the marine sector of the Cananeia estuarine lagoon in the State of São Paulo, Brazil, is described. The studied area is a lower intertidal mud-flat with a scattered Spartina alter- niflora cover. In relation to the total density, Metamysidopsis elongata atlantica dominated the suprabenthos. In relation to the total biomass, fish was the dominant group, followed by M. elongata atlantica and juveniles of Penaeus schimitti. In this suprabenthic community there was a sequential appearance, with high abundance, then disappearance of temporary supra- benthic species, besides strong temporal fluctuations of permanent species. Temporal variations of community diversity were greatly influenced by the local population dynamics, showing a clear seasonal pattern, negatively linked to peaks of density of dominant species and positively with evenness values. The density displayed a distinct pattern of seasonal changes, with high values in spring months, due to the abundance peak of M. elongata atlantica, followed by a marked decline in summer. In short, the suprabenthic community analysed is characterized by a low species richness, low diversity values, and strong temporal fluctuations in species density.
Cubas et al_S1_S2_S3_S4_S5_S6_ESM ;Cubas et al_dataset from Endemic plant species are more palatable to introduced herbivores than non-endemics.
Creators: name: Jonay Cubas
name: Irl, Severin D. H.
name: Villafuerte, Rafael
name: Bello-Rodríguez, Víctor
name: Rodríguez-Luengo, Juan Luis
name: Arco, Marcelino Del
name: Martín-Esquivel, José Luís
name: González-Mancebo, Juana María
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: S1. Graph showing climate space of Tenerife. S2. Table of ecosystems on Tenerife. S3. Correction function applied to rabbit density estimation. S4. Conceptual path diagram for the structrual equation model. S5. Table of the standardized effects of structural equation model output. S6. Generalized limear mixed effects model; S7. Dataset of all abiotic and biotic data used in this study
Oleoylethanolamide, an endogenous PPAR-α ligand, attenuates liver fibrosis targeting hepatic stellate cells
Creators: name: Chen, Junde
name: Li, Long
name: Ren, Jie
name: Li, Lei
name: Qiu, Yan
name: Chen, Ling
name: Zheng, Zihan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Oleoylethanolamide (OEA), an endocannabinoid-like molecule, was revealed to modulate lipid metabolism through a peroxisome proliferator-activated receptor-α (PPAR-α) mediated mechanism. In present study, we further investigated the activities and mechanisms of OEA in ameliorating hepatic fibrosis in Sv/129 mice induced by a methionine choline-deficient (MCD) diet or thioacetamide (TAA) treatment. Liver fibrosis development was assessed by Hematoxylin-eosin and Sirius red staining. Treatment with OEA (5 mg/kg/day, intraperitoneal injection, i.p.) significantly attenuated the progress of liver fibrosis in both two experimental animal models by blocking the activation of hepatic stellate cells (HSCs). Gene expression analysis of hepatic tissues indicated that OEA inhibited the expression of α-smooth muscle action (α-SMA) and collagen matrix, fibrosis markers, and genes involved in inflammation and extracellular matrix remodeling. In vitro studies showed that OEA inhibited transforming growth factor β1-stimulated HSCs activation through suppressing Smad2/3 phosphorylation, α-SMA expression and myofibroblast transformation. These improvements could not be observed in PPAR-α knockout mice models with OEA administration, which suggested all the anti-fibrotic effects of OEA in vivo and in vitro were mediated by PPAR-α activation. Collectively, our results suggested that OEA exerted a pharmacological effect on modulating hepatic fibrosis development through the inhibition of HSCs activation in liver and therefore may be a potential therapeutic agent for liver fibrosis.
(400861) William Myles
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Prognostic impact of c-Rel nuclear expression and REL amplification and crosstalk between c-Rel and the p53 pathway in diffuse large B-cell lymphoma
Creators: name: Young, Ken H.
name: Piris, Miguel A.
name: Ferreri, Andrés J.M.
name: van Krieken, J. Han
name: Huh, Jooryung
name: Ponzoni, Maurilio
name: Xu-Monette, Zijun Y.
name: Zu, Youli
name: Hsi, Eric D.
name: Richards, Kristy L.
name: Jeffrey Medeiros, L.
name: Møller, Michael B.
name: Ok, Chi Young
name: Montes-Moreno, Santiago
name: Manyam, Ganiraju C.
name: Chiu, April
name: Dybkaer, Karen
name: Tzankov, Alexandar
name: Wang, Jinfen
name: Parsons, Ben M.
name: Visco, Carlo
name: Choi, William W.L.
name: Winter, Jane N.
name: Li, Ling
name: Pham, Lan V.
name: Zhang, Mingzhi
name: Sun, Ruifang
name: Orazi, Attilio
name: Bhagat, Govind
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Dysregulated NF-κB signaling is critical for lymphomagenesis. The regulation, function, and clinical relevance of c-Rel/NF-κB activation in diffuse large B-cell lymphoma (DLBCL) have not been well studied. In this study we analyzed the prognostic significance and gene-expression signature of c-Rel nuclear expression as surrogate of c-Rel activation in 460 patients with de novo DLBCL. Nuclear c-Rel expression, observed in 137 (26.3%) DLBCL patients frequently associated with extranoal origin, did not show significantly prognostic impact in the overall- or germinal center B-like-DLBCL cohort, likely due to decreased pAKT and Myc levels, up-regulation of FOXP3, FOXO3, MEG3 and other tumor suppressors coincided with c-Rel nuclear expression, as well as the complicated relationships between NF-κB members and their overlapping function. However, c-Rel nuclear expression correlated with significantly poorer survival in p63+ and BCL-2− activated B-cell-like-DLBCL, and in DLBCL patients with TP53 mutations. Multivariate analysis indicated that after adjusting clinical parameters, c-Rel positivity was a significantly adverse prognostic factor in DLBCL patients with wild type TP53. Gene expression profiling suggested dysregulations of cell cycle, metabolism, adhesion, and migration associated with c-Rel activation. In contrast, REL amplification did not correlate with c-Rel nuclear expression and patient survival, likely due to co-amplification of genes that negatively regulate NF-κB activation. These insights into the expression, prognostic impact, regulation and function of c-Rel as well as its crosstalk with the p53 pathway underscore the importance of c-Rel and have significant therapeutic implications.
Cubas et al_S1_S2_S3_S4_S5_S6_ESM ;Cubas et al_dataset from Endemic plant species are more palatable to introduced herbivores than non-endemics
Creators: name: Jonay Cubas
name: Irl, Severin D. H.
name: Villafuerte, Rafael
name: Bello-Rodríguez, Víctor
name: Rodríguez-Luengo, Juan Luis
name: Arco, Marcelino Del
name: Martín-Esquivel, José Luís
name: González-Mancebo, Juana María
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: S1. Graph showing climate space of Tenerife. S2. Table of ecosystems on Tenerife. S3. Correction function applied to rabbit density estimation. S4. Conceptual path diagram for the structrual equation model. S5. Table of the standardized effects of structural equation model output. S6. Generalized limear mixed effects model;S7. Dataset of all abiotic and biotic data used in this study
Three species of the genus Plesionika Bate, 1888 (Caridea: Pandalidae) reported for the first time in the southwestern Atlantic
Creators: name: CARDOSO, Irene A.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2011

description: The genus Plesionika Bate, 1888 comprises numerous species occurring in all oceans, except in high latitudes. The Program REVIZEE sampled at Brazilian central coast (between 11°S and 22°S) in depths between 200 and 2000 m. Three Plesionika species were sampled and recorded for the first time in the southwestern Atlantic: Plesionika gigliolii (Senna, 1903), P. longipes (A. Milne Edwards, 1881) and P. macropoda Chace, 1939.
Stat3 orchestrates interaction between endothelial and tumor cells and inhibition of Stat3 suppresses brain metastasis of breast cancer cells
Creators: name: Sawaya, Raymond
name: Priebe, Waldemar
name: Conrad, Charles A.
name: Zhou, Aidong
name: Lee, Hsueh Te
name: Huang, Suyun
name: Yang, Phillip
name: Patterson, Cam
name: Aldape, Kenneth D.
name: Xie, Keping
name: Xue, Jianfei
name: Chou, Ping Chieh
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Brain metastasis is a major cause of morbidity and mortality in patients with breast cancer. Our previous studies indicated that Stat3 plays an important role in brain metastasis. Here, we present evidence that Stat3 functions at the level of the microenvironment of brain metastases. Stat3 controlled constitutive and inducible VEGFR2 expression in tumor-associated brain endothelial cells. Furthermore, inhibition of Stat3 by WP1066 decreased the incidence of brain metastases and increased survival in a preclinical model of breast cancer brain metastasis. WP1066 inhibited Stat3 activation in tumor-associated endothelial cells, reducing their infiltration and angiogenesis. WP1066 also inhibited breast cancer cell invasion. Our results indicate that WP1066 can inhibit tumor angiogenesis and brain metastasis mediated by Stat3 in endothelial and tumor cells.
Alien marine bivalve species reported from Turkish seas
Creators: name: ALBAYRAK, Serhat
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2011

description: Literature review revealed a total of 31 valid alien bivalve species reported from the seas surrounding Turkey. In this study, these species were documented and their distributions in Turkish coasts were explained. Introducing pathways and rates of alien bivalves were discussed.
(400860) Betty Baxter
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Description, distribution and microhabitats of a new species of Tisbe (Copepoda: Harpacticoida: Tisbidae) from a deep-sea hydrothermal vent field at the Mid-Atlantic Ridge (37°N, Lucky Strike)
Creators: name: IVANENKO, Viatcheslav N.
name: FERRARI, Frank D.
name: DEFAYE, Danielle
name: SARRADIN, Pierre-Marie
name: SARRAZIN, Jozée
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2011

description: A new species, Tisbe dahmsi sp. nov. (Crustacea, Copepoda: Harpacticoida: Tisbidae) is described from the Eiffel Tower edifice located in the Lucky Strike vent field (37°N) (Mid-Atlantic Ridge MAR, 1698 m). The samples were collected in colonization experiments (SMAC arrays) that were deployed in 1997 during the MARVEL cruise and recovered in 1998 during the PICO cruise. Other specimens were collected during the MoMARETO cruise during which a physico-chemical characterization of copepod microhabitats was done. The new species belongs to the T. gracilis group based on similarities of the spine-like inner seta on the proximal endopodal segment of the male second swimming leg, which is terminally bifurcate. Re-examination of the closest relative and shallow-water species T. gracilis revealed a number of distinctions, including differences in shape and ornamentation of this terminally bifurcate seta. Tisbe dahmsi sp. nov. is found abundantly in the in situ colonization experiments (SMAC arrays) deployed on Bathymodiolus azoricus mussel assemblages at the Eiffel Tower edifice, together with the cyclopoid copepod Hepterina confusa Ivanenko & Defaye, 2004 (Cyclopoida: Cyclopinidae), the harpacticoid copepod Smacigastes micheli Ivanenko & Defaye, 2004 (Harpacticoida: Tegastidae) and the dirivultid copepod Aphotopontius atlanteus Humes, 1996 (Siphonostomatoida: Dirivultidae). Another colonization experiment, deployed near a black smoker, exhibits a different pattern with dominance
 of the harpacticoid families Ameiridae and Argestidae of the Ectinosomatidae family. These colonization experiments revealed that copepods of the genus Tisbe were substantially more abundant in the trays deployed on mussel assemblages than to those in the vicinity of black smokers. Nevertheless, no clear response regarding the effect of organic enrichment on copepod abundance was observed. The type of environment where the arrays were deployed appears to have a stronger influence on copepod abundances and composition than the treatment applie
Two new free-living marine nematode species of the genus Vasostoma (Comesomatidae) from the China Sea
Creators: name: HUANG, Yong
name: WU, Xiuqin
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2011

description: Two new species of free-living marine nematodes Vasostoma brevispicula sp. nov. from the Yellow Sea and Vasostoma longicaudata sp. nov. from the South China Sea are described. Vasostoma brevispicula sp. nov. is characterized by its thin and long body, amphideal fovea with two and a half turns, tubular buccal cavity with three small tooth-like projections, long pyriform pharyngeal bulb, curved spicules with central lamella. Vasostoma longicaudata sp. nov. is characterized by its long filiform portion of tail and without terminal setae, long tubular buccal cavity with three teeth, curved spicules with ventral alae.
(400858) Mary Meffan
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Supplementary Information from Processing bias: extending sensory drive to include efficacy and efficiency in information processing.
Creators: name: Renoult, Julien P.
name: Mendelson, Tamra C.
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Neuroscience
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 10202 Biological Mathematics
subject: FOS: Mathematics

description: Box S1 (How animals process information); Box S2 (Testing processing bias); Box S3 (Estimating processing efficiency in visual communication)
title: Zur Kenntnis der Azulene, XIII. Elektrophile Substitutionen des Azulens in 2- und 5- bzw. 7-Stellung
Creators: name: Hafner, Klaus
name: Moritz, Karl-Ludwig
Publisher: name: Wiley-VCH
Year: 2023

description: 1.3-Disubstituierte Azulene reagieren mit elektrophilen Agenzien unter Substitution in 5- und/oder 7- sowie in 2-Stellung. Dabei wird die Substitution von elektrophilen Verdrängungsreaktionen in 1- und/oder 3-Stellung begleitet.
(400350) George (JNR) Dicksen
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
SWI/SNF complexes are required for full activation of the DNA-damage response
Creators: name: Chastain, Paul D.
name: Nakamura, Jun
name: Ridpath, John R.
name: Kaufman, David G.
name: Rosson, Gary B.
name: Kaufmann, William K.
name: Holley, Darcy
name: Bultman, Scott J.
name: Smith-Roe, Stephanie L.
name: Simpson, Dennis A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: SWI/SNF complexes utilize BRG1 (also known as SMARCA4) or BRM (also known as SMARCA2) as alternative catalytic subunits with ATPase activity to remodel chromatin. These chromatin-remodeling complexes are required for mammalian development and are mutated in ~20% of all human primary tumors. Yet our knowledge of their tumor-suppressor mechanism is limited. To investigate the role of SWI/SNF complexes in the DNA-damage response (DDR), we used shRNAs to deplete BRG1 and BRM and then exposed these cells to a panel of 6 genotoxic agents. Compared to controls, the shRNA knockdown cells were hypersensitive to certain genotoxic agents that cause double-strand breaks (DSBs) associated with stalled/collapsed replication forks but not to ionizing radiation-induced DSBs that arise independently of DNA replication. These findings were supported by our analysis of DDR kinases, which demonstrated a more prominent role for SWI/SNF in the activation of the ATR-Chk1 pathway than the ATM-Chk2 pathway. Surprisingly, γH2AX induction was attenuated in shRNA knockdown cells exposed to a topoisomerase II inhibitor (etoposide) but not to other genotoxic agents including IR. However, this finding is compatible with recent studies linking SWI/SNF with TOP2A and TOP2BP1. Depletion of BRG1 and BRM did not result in genomic instability in a tumor-derived cell line but did result in nucleoplasmic bridges in normal human fibroblasts. Taken together, these results suggest that SWI/SNF tumor-suppressor activity involves a role in the DDR to attenuate replicative stress and genomic instability. These results may also help to inform the selection of chemotherapeutics for tumors deficient for SWI/SNF function.
A new record of Periclimenes pholeter Holthuis, 1973 (Crustacea: Decapoda: Pontoniinae) from the Red Sea
Creators: name: BRUCE, Alexander J.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2011

description: The pontoniine shrimp, Periclimenes pholeter Holthuis, 1973, is reported from 2148 m in the Red Sea, the first time a pontoniine shrimp has been recorded from over 2000 m.
Photodesorption of H2O, HDO, and D2O ice and its impact on fractionation
Creators: name: Arasa, Carina
name: Koning, Jesper
name: Kroes, Geert-Jan
name: Walsh, Catherine
name: van Dishoeck, Ewine F.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The HDO/H2O ratio in interstellar gas is often used to draw conclusions on the origin of water in star-forming regions and on Earth. In cold cores and in the outer regions of protoplanetary disks, gas-phase water comes from photodesorption of water ice. We present fitting formulae for implementation in astrochemical models using photodesorption efficiencies for all water ice isotopologues obtained using classical molecular dynamics simulations. We investigate if the gas-phase HDO/H2O ratio reflects that present in the ice or whether fractionation can occur during photodesorption. Probabilities for the top four monolayers are presented for photodesorption of X (X=H,D) atoms, OX radicals, and X2O and HDO molecules following photodissociation of H2O, D2O, and HDO in H2O amorphous ice at temperatures from 10-100 K. Isotope effects are found for all products: (1) H atom photodesorption probabilities from H2O ice are larger than those for D atom photodesorption from D2O ice by a factor of 1.1; the ratio of H and D photodesorbed upon HDO photodissociation is a factor of 2. This process will enrich the ice in deuterium atoms over time; (2) the OD/OH photodesorption ratio upon D2O and H2O photodissociation is on average a factor of 2, but the ratio upon HDO photodissociation is almost constant at unity for all temperatures; (3) D atoms are more effective in kicking out neighbouring water molecules than H atoms. However, the ratio of the photodesorbed HDO and H2O molecules is equal to the HDO/H2O ratio in the ice, therefore, there is no isotope fractionation upon HDO and H2O photodesorption. Nevertheless, the enrichment of the ice in D atoms due to photodesorption can over time lead to an enhanced HDO/H2O ratio in the ice, and, when photodesorbed, also in the gas. The extent to which the ortho/para ratio of H2O can be modified by the photodesorption process is also discussed. (Abridged)
description: 12 pages, 3 figures, accepted for publication in Astronomy & Astrophysics
(400347) Ann Drysdale
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The gain-of-function GLI1 transcription factor TGLI1 enhances expression of VEGF-C and TEM7 to promote glioblastoma angiogenesis
Creators: name: Sirkisoon, Sherona
name: Watabe, Kounosuke
name: Paw, Ivy
name: Zhu, Hu
name: Xing, Fei
name: Debinski, Waldemar
name: Lo, Hui Wen
name: Carpenter, Richard L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: We recently discovered that truncated glioma-associated oncogene homolog 1 (TGLI1) is highly expressed in glioblastoma (GBM) and linked to increased GBM vascularity. The mechanisms underlying TGLI1-mediated angiogenesis are unclear. In this study, we compared TGLI1- with GLI1-expressing GBM xenografts for the expression profile of 84 angiogenesis-associated genes. The results showed that expression of six genes were upregulated and five were down-regulated in TGLI1-carrying tumors compared to those with GLI1. Vascular endothelial growth factor-C (VEGF-C) and tumor endothelial marker 7 (TEM7) were selected for further investigations because of their significant correlations with high vascularity in 135 patient GBMs. TGLI1 bound to both VEGF-C and TEM7 gene promoters. Conditioned medium from TGLI1-expressing GBM cells strongly induced tubule formation of brain microvascular endothelial cells, and the induction was prevented by VEGF-C/TEM7 knockdown. Immunohistochemical analysis of 122 gliomas showed that TGLI1 expression was positively correlated with VEGF-C, TEM7 and microvessel density. Analysis of NCBI Gene Expression Omnibus datasets with 161 malignant gliomas showed an inverse relationship between tumoral VEGF-C, TEM7 or microvessel density and patient survival. Together, our findings support an important role that TGLI1 plays in GBM angiogenesis and identify VEGF-C and TEM7 as novel TGLI1 target genes of importance to GBM vascularity.
Cyclaspis giveni sp. nov. (Crustacea: Cumacea) from Bahia de Todos Santos, Baja California, Mexico
Creators: name: DONATH-HERNANDEZ, Francisco E.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2011

description: The order Cumacea (Crustacea, Peracarida), of the Mexican coast is poorly known. Previous descriptions of new species have been limited to the Gulf of California. With the description of Cyclaspis giveni sp. nov. from Bahia de Todos Santos, four species of the genus Cyclaspis, are now known to occur in the coast of Baja California: Cyclaspis nubila Zimmer, 1936, C. concepcionensis Donath-Hernández, 1988 and C. bituberculata Donath-Hernández, 1988.
Transcriptome-wide identification and study of cancer-specific splicing events across multiple tumors
Creators: name: Gomez, Shawn M.
name: Wang, Zefeng
name: Tsai, Yihsuan S.
name: Dominguez, Daniel
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Dysregulation of alternative splicing (AS) is one of the molecular hallmarks of cancer, with splicing alteration of numerous genes in cancer patients. However, studying splicing mis-regulation in cancer is complicated by the large noise generated from tissue-specific splicing. To obtain a global picture of cancer-specific splicing, we analyzed transcriptome sequencing data from 1149 patients in The Cancer Genome Atlas project, producing a core set of AS events significantly altered across multiple cancer types. These cancer-specific AS events are highly conserved, are more likely to maintain protein reading frame, and mainly function in cell cycle, cell adhesion/migration, and insulin signaling pathways. Furthermore, these events can serve as new molecular biomarkers to distinguish cancer from normal tissues, to separate cancer subtypes, and to predict patient survival. We also found that most genes whose expression is closely associated with cancer-specific splicing are key regulators of the cell cycle. This study uncovers a common set of cancer-specific AS events altered across multiple cancers, providing mechanistic insight into how splicing is mis-regulated in cancers.
Supplementary Information from Processing bias: extending sensory drive to include efficacy and efficiency in information processing
Creators: name: Renoult, Julien P.
name: Mendelson, Tamra C.
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Neuroscience
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 10202 Biological Mathematics
subject: FOS: Mathematics

description: Box S1 (How animals process information); Box S2 (Testing processing bias); Box S3 (Estimating processing efficiency in visual communication)
Heterotrimeric G protein signalling in the plant kingdom
Creators: name: Urano, Daisuke
name: Chen, Jin Gui
name: Botella, José Ramón
name: Jones, Alan M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: In animals, heterotrimeric G proteins, comprising α-, β-and γ-subunits, perceive extracellular stimuli through cell surface receptors, and transmit signals to ion channels, enzymes and other effector proteins to affect numerous cellular behaviours. In plants, G proteins have structural similarities to the corresponding molecules in animals but transmit signals by atypical mechanisms and effector proteins to control growth, cell proliferation, defence, stomate movements, channel regulation, sugar sensing and some hormonal responses. In this review, we summarize the current knowledge on the molecular regulation of plant G proteins, their effectors and the physiological functions studied mainly in two model organisms: Arabidopsis thaliana and rice (Oryza sativa). We also look at recent progress on structural analyses, systems biology and evolutionary studies.
Stephen Hawking - Bibliography from Stephen William Hawking CH CBE. 8 January 1942 — 14 March 2018.
Creators: name: Carr, Bernard J.
name: Ellis, George F. R.
name: Gibbons, Gary W.
name: Hartle, James B.
name: Hertog, Thomas
name: Penrose, Roger
name: Perry, Malcolm J.
name: Thorne, Kip S.
name: Longair, Malcolm
Publisher: name: The Royal Society
Year: 2019
Subjects: Astrophysics

description: Stephen Hawking's contributions to the understanding of gravity, black holes and cosmology were truly immense. They began with the singularity theorems in the 1960s followed by his discovery that black holes have an entropy and consequently a finite temperature. Black holes were predicted to emit thermal radiation, what is now called Hawking radiation. He pioneered the study of primordial black holes and their potential role in cosmology. His organization of and contributions to the Nuffield Workshop in 1982 consolidated the picture that the large-scale structure of the universe originated as quantum fluctuations during the inflationary era. Work on the interplay between quantum mechanics and general relativity resulted in his formulation of the concept of the wavefunction of the universe. The tension between quantum mechanics and general relativity led to his struggles with the information paradox concerning deep connections between these fundamental areas of physics.These achievements were all accomplished following the diagnosis during the early years of Stephen's studies as a post-graduate student in Cambridge that he had incurable motor neuron disease—he was given two years to live. Against all the odds, he lived a further 55 years. The distinction of his work led to many honours and he became a major public figure, promoting with passion the needs of disabled people. His popular best-selling book, A brief history of time, made cosmology and his own work known to the general public world-wide. He became an icon for science and an inspiration to all.