cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Role of boundary conditions, topology and disorder in the chiral magnetic effect in Weyl semimetals
Creators: name: Alavirad, Yahya
name: Sau, Jay D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Quantum field theory predicts Weyl semimetals to possess a peculiar response of the longitudinal current density to the application of a DC magnetic field. Such a response function has been shown to be at odds with a general result showing the vanishing of the bulk current in an equilibrium system on any real material with a lattice in an external magnetic field. Here we resolve this apparent contradiction by introducing a model where a current flows in response to a magnetic field even without Weyl nodes. We point out that the previous derivation of a vanishing CME in the limit of vanishing real frequency is a consequence of the assumption of periodic boundary conditions of the system. A more realistic system with open boundary conditions is not subject to these constraints and can have a non-vanishing CME. Consistent with recent work, we found the finite frequency CME to be non-vanishing in general when there was a non-vanishing Berry curvature on the Fermi surface. This does not necessitate having a topological Berry flux as in the case of a Weyl node. Finally, we study how the perturbation theory in magnetic field might be more stable in the presence of disorder. Using the standard diagrammatic treatment of disorder within the Born approximation, we have found that in a realistic disordered system, the chiral magnetic response is really a dynamical phenomena and vanishes in the DC limit.
description: 8 pages, 3 figures, 2 pages of appendix; Revised and expanded, title updated
Political Leader Preferences during the COVID-19 Pandemic
Creators: name: Tucciarelli, Raffaele
name: Tsakiris, Manos
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences
subject: COVID19
subject: Political decisions

description: How do people take political decisions during prolematic period, as during the COVID19 crisis? This project is part of a collaborative initernational project on COVID10 (COVID Many Labs 2020)
Germline Analysis from Tumor–Germline Sequencing Dyads to Identify Clinically Actionable Secondary Findings
Creators: name: Earp, H. Shelton
name: Marron, Andrew
name: Wilhelmsen, Kirk C.
name: Evans, James P.
name: Seifert, Bryce A.
name: Patel, Nirali M.
name: Hoyle, Alan P.
name: Parker, Joel S.
name: Hayward, Michele C.
name: Berg, Jonathan S.
name: Bizon, Christopher
name: Sharpless, Norman E.
name: Mose, Lisle E.
name: O'Daniel, Julianne M.
name: Amin, Krunal
name: Hayes, D. Neil
name: Marchuk, Daniel S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: To evaluate germline variants in hereditary cancer susceptibility genes among unselected cancer patients undergoing tumor-germline sequencing.
Impact of Hypothermic Temperature Control on Plasma and Soft Tissue Pharmacokinetics of Penicillin/Beta-Lactamase Inhibitor Combinations in Patients Resuscitated After Cardiac Arrest
Creators: name: Stommel, Alexandra-Maria
name: Matzneller, Peter
name: al Jalali, Valentin
name: Wulkersdorfer, Beatrix
name: Lackner, Edith
name: Mueller, Matthias
name: Dorn, Christoph
name: Holzer, Michael
name: Zeitlinger, Markus
Publisher: name: Universität Regensburg
Year: 2025
Subjects: subject: 615 Pharmazie

description: Background and objectives: Penicillin/beta-lactamase inhibitors are often used to treat aspiration pneumonia in patients resuscitated after cardiac arrest (CA). The impact of hypothermic temperature control on the pharmacokinetics of amoxicillin/clavulanate (AMO/CLAV) and ampicillin/sulbactam (AMP/SULB) has not been studied. Our objective was to evaluate the effects of hypothermic temperature control on the plasma and soft tissue pharmacokinetics of AMO/CLAV and AMP/SULB, including pulmonary concentrations of AMP/SULB, in patients resuscitated after CA.

Methods: This prospective clinical study involved ten adult patients after CA receiving either AMO/CLAV 2 g/0.2 g or AMP/SULB 2 g/1 g intravenously every 8 h. Patients underwent hypothermic temperature control (33 ± 1 °C) for 24 h, followed by normothermia. Plasma, urine, muscle, and subcutaneous pharmacokinetics were measured and plasma protein-binding assessed for each subject. Microdialysis determined unbound drug concentrations in soft tissues. The pulmonary concentration of AMP/SULB was analyzed in the epithelial lining fluid.

Results: No significant differences in plasma pharmacokinetics or renal excretion of AMO/CLAV and AMP/SULB were observed between the two temperature conditions. Soft tissue concentrations showed no consistent trend. Pharmacokinetic/pharmacodynamic targets (time that the unbound plasma concentrations were above the minimal inhibitory concentration [MIC] for MIC up to 8 mg/L) were met but not for 16 mg/L. Pulmonary concentrations of AMP/SULB in the epithelial lining fluid showed no clear trend.

Conclusion: This study indicates that hypothermic temperature control does not significantly affect plasma concentrations, soft tissue concentrations, or renal excretion of AMO/CLAV and AMP/SULB in patients resuscitated after CA. However, pulmonary concentrations of AMP/SULB exhibited interindividual variability.
A discerning gravitational property for gravitational equation in higher dimensions
Creators: name: Dadhich, Naresh
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: It is well-known that Einstein gravity is kinematic (no non-trivial vacuum solution;i.e. Riemann vanishes whenever Ricci does so) in $3$ dimension because Riemann is entirely given in terms of Ricci. Could this property be universalized for all odd dimensions in a generalized theory? The answer is yes, and this property uniquely singles out pure Lovelock (it has only one $N$th order term in action) gravity for which $N$th order Lovelock Riemann tensor is indeed given in terms of corresponding Ricci for all odd $d=2N+1$ dimensions. This feature of gravity is realized only in higher dimensions and it uniquely picks out pure Lovelock gravity from all other generalizations of Einstein gravity. It serves as a good discerning and guiding criterion for gravitational equation in higher dimensions.
Exploring the internationalization of extreme right public spheres
Creators: name: Kerschbaum, Alisa
name: Veilleux-Lepage, Yannick
name: Lokmanoglu, Ayse
name: Pruden, Meredith
name: Goodwin, Carissa
name: Walter, Dror
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Communication
subject: Social Influence and Political Communication
subject: Social Media
subject: Organizational Communication
subject: Political Science
subject: FOS: Political science
subject: International Relations
subject: Interpersonal and Small Group Communication
subject: Social and Behavioral Sciences
subject: Communication Technology and New Media

description: This research project aims at exploring the extreme right in the English-speaking world in the context of the Internet and internationalization, including the degree and form of political mobilization, communication across organizations, recurrent issues, and audience targets. For this purpose, the research combines social movement analysis, a novel machine learning method, and a manual content analysis.
Beyond Minimal Lepton Flavored Dark Matter
Creators: name: Chen, Mu-Chun
name: Huang, Jinrui
name: Takhistov, Volodymyr
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We consider a class of flavored dark matter (DM) theories where dark matter interacts with the Standard Model lepton fields at the renormalizable level. We allow for a general coupling matrix between the dark matter and leptons whose structure is beyond the one permitted by the minimal flavor violation (MFV) assumption. It is assumed that this is the only new source of flavor violation in addition to the Standard Model (SM) Yukawa interactions. The setup can be described by augmenting the SM flavor symmetry by an additional $\mathrm{SU}(3)_χ$, under which the dark matter $χ$ transforms. This framework is especially phenomenologically rich, due to possible novel flavor-changing interactions which are not present within the more restrictive MFV framework. As a representative case study of this setting, which we call "beyond MFV" (BMFV), we consider Dirac fermion dark matter which transforms as a singlet under the SM gauge group and a triplet under $\mathrm{SU}(3)_χ$. The DM fermion couples to the SM lepton sector through a scalar mediator $ϕ$. Unlike the case of quark-flavored DM, we show that there is no $\mathbb{Z}_3$ symmetry within either the MFV or BMFV settings which automatically stabilizes the lepton-flavored DM. We discuss constraints on this setup from flavor-changing processes, DM relic abundance as well as direct and indirect detections. We find that relatively large flavor-changing couplings are possible, while the dark matter mass is still within the phenomenologically interesting region below the TeV scale. Collider signatures which can be potentially searched for at the lepton and hadron colliders are discussed. Finally, we discuss the implications for decaying dark matter, which can appear if an additional stabilizing symmetry is not imposed.
description: 30 pages, 12 figures; minor corrections, added references and discussion on decaying dark matter, matches published version
Scoping review protocol: Sensory processing changes in dementia
Creators: name: Rizzo, Isabella
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: Mental and Social Health

description: This registration describes the protocol for a scoping review that aims to explore the available evidence concerning sensory processing changes in care home residents with dementia, with specific focus placed on scoping the existing research investigating the impact of such symptoms on quality of care and challenging behaviours in dementia.
title: Dose reduction in Cardiac CT using iterative reconstruction
Creators: name: Van Beek, Edwin
Publisher: name: ESR EuroSafe Imaging
Year: 2016
Subjects: subject: Action 4 - Quality of radiological equipment
subject: Action 3 - Optimisation, diagnostic reference levels, image quality
subject: Action 2 - Clinical audit
subject: Action 6 - Clinical audit tool for imaging
subject: Action 2 - Clinical diagnostic reference levels (DRLs)
subject: Action 3 - Image quality assessment based on clinical indications

description: Background/Introduction Description of activity and work performed Conclusion and Recommendations Personal/Organisational information References
description: Background/Introduction: Radiation dose is an important concern in cardiovascular imaging. Repeated testing and traditionally high radiation dose examinations means that cardiac imaging is responsible for a major proportion of radiation exposure due to medical...
title: The role of the Medical Physics Expert in Diagnostic and Interventional Radiology
Creators: name: Damilakis, John
Publisher: name: ESR EuroSafe Imaging
Year: 2016
Subjects: subject: Action 10 - Improved communication and collaboration of health professionals in radiation protection
subject: Action 4 - Quality of radiological equipment
subject: Action 3 - Optimisation, diagnostic reference levels, image quality
subject: Action 2 - Clinical diagnostic reference levels (DRLs)
subject: Action 3 - Image quality assessment based on clinical indications
subject: Action 13 - Stakeholder engagement and collaboration

description: Background/Introduction Description of activity and work performed Conclusion and Recommendations Personal/Organisational information References
description: Background/Introduction: The new European Union (EU) Basic Safety Standards (BSS) Directive (1) defines the ‘medical physics expert’ as ‘an individual or, if provided for in national legislation, a group of individuals, having the knowledge, training and experience to...
High Intratumoral Stromal Content Defines Reactive Breast Cancer as a Low-risk Breast Cancer Subtype
Creators: name: Dennison, Jennifer B.
name: Ju, Zhenlin
name: Shahmoradgoli, Maria
name: Sahin, Aysegul A.
name: Liu, Wenbin
name: Sikora, Matthew J.
name: Brown, Robert E.
name: Mills, Gordon B.
name: Oesterreich, Steffi
name: Meric-Bernstam, Funda
name: Welm, Alana
name: Perou, Charles M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The current study evaluated associative effects of breast cancer cells with the tumor microenvironment and its influence on tumor behavior.
Semi-Permanent Restorations Just Temporary or Long-Lasting Use?: A Review of The Literatures
Creators: name: Pattarika Angkasith
Publisher: name: Faculty of Dentistry, Chiang Mai University
Year: 2023
Subjects: acrylic resin
cementation
composite resin
permanent restoration
provisional restoration

description: Chiang Mai Dental Journal, 44, 1, 13-21
title: Assessment of students and residents' awareness of radiation protection in a teaching hospital
Creators: name: Caramella, Davide
Publisher: name: ESR EuroSafe Imaging
Year: 2016
Subjects: subject: Action 9 - Development of criteria for safe imaging procedures
subject: Action 7 - Medical radiation protection research: MELODI, EURAMED
subject: Action 6 - Education and training in medical radiation protection
subject: Action 8 - Radiation protection training and learning material
subject: Action 9 - Facilitation of research in advanced topics of radiation protection
subject: Action 5 - Performance indicators for radiation protection management

description: Background/Introduction Description of activity and work performed Conclusion and Recommendations Personal/Organisational information References
description: Background/Introduction: Several radiological examinations may expose patients to significant amounts of ionizing radiation [1-3]. Furthermore, recent evolution of some radiological modalities has increased the number of performed examinations, rising concerns in the...
Spectral Motion Synchronization in SE(3)
Creators: name: Arrigoni, Federica
name: Fusiello, Andrea
name: Rossi, Beatrice
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: This paper addresses the problem of motion synchronization (or averaging) and describes a simple, closed-form solution based on a spectral decomposition, which does not consider rotation and translation separately but works straight in SE(3), the manifold of rigid motions. Besides its theoretical interest, being the first closed form solution in SE(3), experimental results show that it compares favourably with the state of the art both in terms of precision and speed.
Molecular Pathways: Interleukin-35 in Autoimmunity and Cancer
Creators: name: Pylayeva-Gupta, Yuliya
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Immunosuppressive functions conferred by regulatory cytokines are important for maintaining homeostasis in immune responses. IL-35 has recently emerged as a novel regulator of immune responses. Once thought to be specifically expressed by T regulatory cells, induction of IL-35 expression has now been detected in multiple cell types in a variety of diseases, prompting research into regulation of its expression, signaling specificity, target cell populations and functional outputs. Recent studies have revealed that by directing de novo generation of regulatory T and B cells and inhibiting T effector responses, IL-35 plays an important role in development of autoimmune diseases and cancer. IL-35 is overexpressed in a variety of cancers and may exert its function both on anti-tumor immune responses as well as directly on tumor cells. As such, IL-35 is rapidly emerging as a promising biomarker and an attractive cancer therapy target.
The environment of barred galaxies revisited
Creators: name: Sodi, Bernardo Cervantes
name: Li, Cheng
name: Park, Changbom
name: Wang, Lixin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present a study of the environment of barred galaxies using galaxies drawn from the SDSS. We use several different statistics to quantify the environment: the projected two-point cross-correlation function, the background-subtracted number count of neighbor galaxies, the overdensity of the local environment, the membership of our galaxies to galaxy groups to segregate central and satellite systems, and for central galaxies we estimate the stellar to halo mass ratio (M$_{\mathrm{*}}/$M$_{\mathrm{h}}$) . When we split our sample into early- and late-type galaxies, we see a weak but significant trend for early-type galaxies with a bar to be more strongly clustered on scales from a few 100 kpc to 1 Mpc when compared to unbarred early-type galaxies. This indicates that the presence of a bar in early-type galaxies depends on the location within their host dark matter halos. This is confirmed by the group catalog in the sense that for early-types, the fraction of central galaxies is smaller if they have a bar. For late-type galaxies, we find fewer neighbors within $\sim50$ kpc around the barred galaxies when compared to unbarred galaxies from the control sample, suggesting that tidal forces from close companions suppress the formation/growth of bars. For central late-type galaxies, bars are more common on galaxies with high M$_{\mathrm{*}}/$M$_{\mathrm{h}}$ values, as expected from early theoretical works which showed that systems with massive dark matter halos are more stable against bar instabilities. Finally, we find no obvious correlation between overdensity and the bars in our sample, showing that galactic bars are not obviously linked to the large-scale structure of the universe.
description: 4 pages, 3 figures, Refereed Proceeding of the "The Universe of Digital Sky Surveys" conference held at the INAF - Observatory of Capodimonte, Naples, on 25th-28th november 2014, to be published on Astrophysics and Space Science Proceedings, edited by Longo, Napolitano, Marconi, Paolillo, Iodice
title: Belgian Medical Imaging Platform - Promoting the rational use of medical imaging
Creators: name: Reynders-Frederix, Nils
Publisher: name: ESR EuroSafe Imaging
Year: 2016
Subjects: subject: Action 10 - Improved communication and collaboration of health professionals in radiation protection
subject: Action 2 - Clinical audit
subject: Action 1 - Clinical decision support, clinical imaging guidelines
subject: Action 1 - Guidelines, implementation policies, and Clinical Decision Support (ESR iGuide)
subject: Action 6 - Clinical audit tool for imaging
subject: Action 13 - Stakeholder engagement and collaboration

description: Background/Introduction Description of activity and work performed Conclusion and Recommendations Personal/Organisational information References
description: Background/Introduction: Objectives of BELMIP Avoid unnecessary irradiation prevent side-effects Improve clinical practice Improve allocation of means personnel, equipment &...
The Musician Advantage for Speech-in-Noise Perception and Its Neural Correlates: A Systematic Review
Creators: name: Sim, Angela
name: Whiteford, Kelly
name: Riegelman, Amy
name: Oxenham, Andrew
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences
subject: Musicianship
subject: speech-in-noise
subject: speech perception

description: Musical training is widespread among the population, but the question of whether the effects of such training generalize to other perceptual or communication skills, or are reflected in early transient and ongoing auditory responses to sound periodicity, remains unclear. This review will include studies that examine the relationship between musical training and either speech-in-noise perception or early (subcortical) and/or periodic neural responses to sound, or both.
Bell-type Inequalities for Arbitrary Non-Cyclic Networks
Creators: name: Tavakoli, Armin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Bell inequalities bound the strength of classical correlations between observers measuring on a shared physical system. However, studies of physical correlations can be considered beyond the standard Bell scenario by networks of observers sharing some configuration of many independent physical systems. Here, we show how to construct Bell-type inequalities for correlations arising in any tree-structured network i.e. networks without cycles. This is achieved by an iteration procedure that in each step allows one to add a branch to the tree-structured network and construct a corresponding Bell-type inequality. We explore our inequalities in several examples, in all of which we demonstrate strong violations from quantum theory.
description: Updated version
Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy
Creators: name: Kelley, Michael J.
name: Nakamura, Yusuke
name: Morris, Michael J.
name: Small, Eric J.
name: Furukawa, Yoichi
name: Dorsey, Susan G.
name: Krens, Stefanie D.
name: Wheeler, Heather E.
name: Lessans, Sherrie
name: McLeod, Howard L.
name: Owzar, Kouros
name: Mulkey, Flora
name: Febbo, Phillip G.
name: Wing, Claudia
name: Watson, Dorothy
name: Lassiter, Cameron
name: Sibley, Alexander B.
name: Friedman, Paula N.
name: Ratain, Mark J.
name: Carducci, Michael A.
name: Jiang, Chen
name: Kubo, Michiaki
name: Halabi, Susan
name: Mahoney, John F.
name: Shterev, Ivo
name: Renn, Cynthia L.
name: Dolan, M. Eileen
name: Weisman, Lois
name: Kelly, William Kevin
name: Patel, Jai
name: Kroetz, Deanna L.
name: Hertz, Daniel L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Discovery of single nucleotide polymorphisms (SNPs) that predict a patient's risk of docetaxel-induced neuropathy would enable treatment individualization to maximize efficacy and avoid unnecessary toxicity. The objectives of this analysis were to discover SNPs associated with docetaxel-induced neuropathy and mechanistically validate these associations in preclinical models of drug-induced neuropathy.
Modelling dust extinction in the Magellanic Clouds
Creators: name: Zonca, Alberto
name: Casu, Silvia
name: Mulas, Giacomo
name: Aresu, Giambattista
name: Cecchi-Pestellini, Cesare
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We model the extinction profiles observed in the Small and Large Magellanic clouds with a synthetic population of dust grains consisting by core-mantle particles and a collection of free-flying polycyclic aromatic hydrocarbons. All different flavors of the extinction curves observed in the Magellanic Clouds can be described by the present model, that has been previously (successfully) applied to a large sample of diffuse and translucent lines of sight in the Milky Way. We find that in the Magellanic Clouds the extinction produced by classic grains is generally larger than absorption by polycyclic aromatic hydrocarbons. Within this model, the non-linear far-UV rise is accounted for by polycyclic aromatic hydrocarbons, whose presence in turn is always associated to a gap in the size distribution of classical particles. This hints either a physical connection between (e.g., a common cause for) polycyclic aromatic hydrocarbons and the absence of middle-sized dust particles, or the need for an additional component in the model, that can account for the non-linear far-UV rise without contributing to the UV bump at $\sim$217 nm, e.g., nanodiamonds.
Taselisib (GDC-0032), a Potent  -Sparing Small Molecule Inhibitor of PI3K, Radiosensitizes Head and Neck Squamous Carcinomas Containing Activating PIK3CA Alterations
Creators: name: Gupta, Gaorav
name: Shiao, Stephan L.
name: Chung, Christine H.
name: Krigsfeld, Gabriel
name: Scaltriti, Maurizio
name: Ganly, Ian
name: Morse, Natasha
name: Baselga, José
name: Morris, Luc
name: Lee, Nancy Y.
name: Zumsteg, Zachary S.
name: Higginson, Daniel S.
name: Powell, Simon N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Activating PIK3CA genomic alterations are frequent in head and neck squamous cell carcinoma (HNSCC), and there is an association between phosphoinositide 3-kinase (PI3K) signaling and radioresistance. Hence, we investigated the therapeutic efficacy of inhibiting PI3K with GDC-0032, a PI3K inhibitor with potent activity against p110α, in combination with radiation in HNSCC.
title: Implementation of a multi country CT Dose Management system
Creators: name: Katsari, Katia
Publisher: name: ESR EuroSafe Imaging
Year: 2016
Subjects: subject: Action 12 - Cooperation with international radiation protection initiatives and other stakeholders including IAEA, WHO, ICRP, HERCA, European Commission
subject: Action 10 - Improved communication and collaboration of health professionals in radiation protection
subject: Action 3 - Optimisation, diagnostic reference levels, image quality
subject: Action 2 - Clinical diagnostic reference levels (DRLs)
subject: Action 13 - Stakeholder engagement and collaboration

description: Background/Introduction Description of activity and work performed Conclusion and Recommendations Personal/Organisational information References
description: Background/Introduction: Introduction Computed Tomography (CT) was first introduced in the early 1970s. It quickly became an essential tool for the diagnosis of many medical conditions and the evaluation of treatment progress. Improved technology and the development of...
Counterdiabatic driving in spin squeezing and Dicke state preparation
Creators: name: Opatrný, Tomáš
name: Saberi, Hamed
name: Brion, Etienne
name: Mølmer, Klaus
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: A method is presented to transfer a system of two-level atoms from a spin coherent state to a maximally spin squeezed Dicke state, relevant for quantum metrology and quantum information processing. The initial state is the ground state of an initial linear Hamiltonian which is gradually turned into a final quadratic Hamiltonian whose ground state is the selected Dicke state. We use compensating operators to suppress diabatic transitions to unwanted states that would occur if the change were not slow. We discuss the possibilities of constructing the compensating operators by sequential application of quadratic Hamiltonians available in experiments.
description: 10 pages, 10 figures. Replaced with published version
Modeling the Storm Surge and Compound Flooding from Hurricane Florence Using ADCIRC
Creators: name: Ratcliff, John
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: How to best model a storm with slow forward speed and record landfall using ADCIRC. Some new opportunities presented with this case for study with ADCIRC are:
• Landfalling East Coast storm with perpendicular approach for ADCIRC skill assessment
• Opportunity to identify/model compound flooding
• Contribute to ‘national’ parameter set for ADCIRC users
• Normalize forecast meteorological product (GAHM) with reanalysis products (OWI)
• Examine datum adjustment (MSL to NAVD88)
title: Radiation Protection Pavilion at CIRSE 2015
Creators: name: CIRSE Radiation Protection Subcommittee,
Publisher: name: ESR EuroSafe Imaging
Year: 2016
Subjects: subject: Action 10 - Improved communication and collaboration of health professionals in radiation protection
subject: Action 5 - Exchange and collaboration with medical industry
subject: Action 4 - Quality of radiological equipment
subject: Action 3 - Image quality assessment based on clinical indications
subject: Action 11 - Dialogue with industry
subject: Action 13 - Stakeholder engagement and collaboration

description: Background/Introduction Description of activity and work performed Conclusion and Recommendations Personal/Organisational information References
description: Background/Introduction: While patient safety is quite rightly a key concern for all diagnostic and interventional radiologists (IRs), occupational radiation protection awareness is often a lower priority. All too frequently, this important topic is given scant attention by...
Bulk and Boundary Invariants for Complex Topological Insulators: From K-Theory to Physics
Creators: name: Prodan, Emil
name: Schulz-Baldes, Hermann
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: This monograph offers an overview on the topological invariants in fermionic topological insulators from the complex classes. Tools from K-theory and non-commutative geometry are used to define bulk and boundary invariants, to establish the bulk-boundary correspondence and to link the invariants to physical observables.
description: Monograph in Springer Series in Mathematical Physics Studies, see ISBN below. Correction of a few remaining typos. ISBN 978-3-319-29350-9, eBook ISBN 978-3-319-29351-6, (Springer, 2016)
title: Dose optimisation in Paediatric Computed Tomography
Creators: name: Saez, Fermin
Publisher: name: ESR EuroSafe Imaging
Year: 2016
Subjects: subject: Action 3 - Optimisation, diagnostic reference levels, image quality
subject: Action 2 - Clinical diagnostic reference levels (DRLs)

description: Background/Introduction Description of activity and work performed Conclusion and Recommendations Personal/Organisational information References
description: Background/Introduction: It isestimated that more than 62 million CT scans are performed each year in the US. Approximately 8-10% of CT examinations are performed in children. The growth in CT utilization is higher in the pediatric than adult population, particularly in...
Factors affecting “entrepreneurial thinking”: the mediating role of interest area
Creators: name: Verma, Vishal
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Business
subject: Social and Behavioral Sciences

description: In this study, the three constructs are selected as entrepreneurial quality, entrepreneurial thinking, and interest area. The entrepreneurial quality is an independent latent variable, the entrepreneurial thinking is a dependent latent variable and interest area is a mediating latent variable
Raman induced soliton self-frequency shift in microresonator Kerr frequency combs
Creators: name: Karpov, Maxim
name: Guo, Hairun
name: Kordts, Arne
name: Brasch, Victor
name: Pfeiffer, Martin
name: Zervas, Michail
name: Geiselmann, Michael
name: Kippenberg, Tobias J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The formation of temporal dissipative solitons in continuous wave laser driven microresonators enables the generation of coherent, broadband and spectrally smooth optical frequency combs as well as femtosecond pulses with compact form factor. Here we report for the first time on the observation of a Raman-induced soliton self-frequency shift for a microresonator soliton. The Raman effect manifests itself in amorphous SiN microresonator based single soliton states by a spectrum that is hyperbolic secant in shape, but whose center is spectrally red-shifted (i.e. offset) from the continuous wave pump laser. The Raman induced spectral red-shift is found to be tunable via the pump laser detuning and grows linearly with peak power. The shift is theoretically described by the first order shock term of the material's Raman response, and we infer a Raman shock time of 20 fs for amorphous SiN. Moreover, we observe that the Raman induced frequency shift can lead to a cancellation or overcompensation of the soliton recoil caused by the formation of a (coherent) dispersive wave. The observations are in excellent agreement with numerical simulations based on the Lugiato-Lefever equation (LLE) with a Raman shock term. Our results contribute to the understanding of Kerr frequency combs in the soliton regime, enable to substantially improve the accuracy of modeling and are relevant to the fundamental timing jitter of microresonator solitons.
A Theory of Equivalent Expectation Measures for Expected Prices of Contingent Claims
Creators: name: Nawalkha, Sanjay
name: Zhuo, Xiaoyang
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Business
subject: EEM Theory
subject: Equivalent Expectation Measures.
subject: Expected future prices of contingent claims
subject: Expected returns of contingent claims

description: This paper introduces a theory of equivalent expectation measures, such as the R-measure and the RT1-measure, generalizing the martingale pricing theory of Harrison and Kreps (1979) for deriving analytical solutions of expected prices—both the expected current price and the expected future price—of contingent claims. We also present new R-transforms which extend the Q-transforms of Bakshi and Madan (2000) and Duffie et al. (2000), for computing the expected prices of a variety of standard and exotic claims under a broad range of stochastic processes. Finally, as a generalization of Breeden and Litzenberger (1978), we propose a new concept of the expected future state price density which allows the estimation of the expected future prices of complex European contingent claims as well as the physical density of the underlying asset’s future price, using the current prices and only the first return moment of standard European OTM call and put options.
title: Eur O’Safe: Ireland’s approach to dose reference levels and preparation for EU Directive 2013/59
Creators: name: Kavanagh, Richard
Publisher: name: ESR EuroSafe Imaging
Year: 2016
Subjects: subject: Action 6 - Education and training in medical radiation protection
subject: Action 3 - Optimisation, diagnostic reference levels, image quality
subject: Action 2 - Clinical audit
subject: Action 6 - Clinical audit tool for imaging
subject: Action 2 - Clinical diagnostic reference levels (DRLs)
subject: Action 8 - Radiation protection training and learning material

description: Background/Introduction Description of activity and work performed Conclusion and Recommendations Personal/Organisational information References
description: Background/Introduction: Ireland held thePresidency of the Council of the European Union from January to July 2013 and during this presidency, it was announced that the text that would ultimately form the European Council Directive 2013/59/Euratom (hereafter referred to as...
A PAM50-Based Chemoendocrine Score for Hormone Receptor–Positive Breast Cancer with an Intermediate Risk of Relapse
Creators: name: Sánchez-Rovira, Pedro
name: Prat, Aleix
name: Arcusa, Angels
name: Chacón, José Ignacio
name: Dunbier, Anita K.
name: Jimenez, Begoña
name: Bin Aiderus, Abdul Aziz
name: Lluch, Ana
name: Caballero, Rosalía
name: Calvo, Lourdes
name: De La Haba-Rodríguez, Juan
name: Paré, Laia
name: Perou, Charles M.
name: Carrasco, Eva
name: Muñoz, Montserrat
name: Dixon, J. Michael
name: Alba, Emilio
name: Dowsett, Mitch
name: Parker, Joel S.
name: Albanell, Joan
name: Adamo, Barbara
name: Plazaola, Arrate
name: Turnbull, Arran K.
name: Ribelles, Nuria
name: Martín, Miguel
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Purpose: Hormone receptor-positive (HR + ) breast cancer is clinically and biologically heterogeneous, and subgroups with different prognostic and treatment sensitivities need to be identified. Experimental Design: Research-based PAM50 subtyping and expression of additional genes was performed on 63 patients with HR + /HER2 - disease randomly assigned to neoadjuvant multiagent chemotherapy versus endocrine therapy in a phase II trial. The biology associated with treatment response was used to derive a PAM50-based chemoendocrine score (CES). CES's predictive ability was evaluated in 4 independent neoadjuvant data sets ( n = 675) and 4 adjuvant data sets ( n = 1,505). The association of CES, intrinsic biology, and PAM50 risk of relapse (ROR) was explored across 6,007 tumors. Results: Most genes associated with endocrine sensitivity were also found associated with chemotherapy resistance. In the chemotherapy test/validation data sets, CES was independently associated with pathologic complete response (pCR), even after adjusting for intrinsic subtype. pCR rates of the CES endocrine-sensitive (CES-E), uncertain (CES-U), and chemotherapy-sensitive (CES-C) groups in both data sets combined were 25%, 11%, and 2%, respectively. In the endocrine test/validation data sets, CES was independently associated with response. Compared with ROR, >90% of ROR-low and ROR-high tumors were identified as CES-E and CES-C, respectively; however, each CES group represented >25% of ROR-intermediate disease. In terms of survival outcome, CES-C was associated with poor relapse-free survival in patients with ROR-intermediate disease treated with either adjuvant endocrine therapy only or no adjuvant systemic therapy, but not in patients treated with (neo)adjuvant chemotherapy. Conclusions: CES is a genomic signature capable of estimating chemoendocrine sensitivity in HR + breast cancer beyond intrinsic subtype and risk of relapse. Clin Cancer Res; 23(12); 3035-44. ©2016 AACR .
A Phase 2/3 Multicenter, Randomized, Open-Label Study to Compare the Efficacy and Safety of Lenalidomide Versus Investigator's Choice in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma
Creators: name: Eberhard, David A.
name: Yang, Yandan
name: Witzig, Thomas E.
name: Hagner, Patrick
name: Slack, Graham W.
name: Lih, Chih-Jian
name: Rule, Simon
name: Brousset, Pierre
name: Song, Dale
name: Williams, P. Mickey
name: Trněný, Marek
name: Linton, Kim M.
name: Zinzani, Pier Luigi
name: Hernandez-Ilizaliturri, Francisco J.
name: Wright, George W.
name: Thakurta, Anjan
name: Salles, Gilles
name: Gascoyne, Randy D.
name: Russo, Jacqueline
name: Lewis, Ian D.
name: Davies, Andrew
name: Wagner-Johnston, Nina
name: Fustier, Pierre
name: Czuczman, Myron S.
name: Staudt, Louis M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Purpose: Randomized, multicenter, open-label, phase 2/3 trial investigating lenalidomide versus investigator's choice (IC) in relapsed/refractory diffuse large B-cell lymphoma (DLBCL).Experimental Design: Patients with DLBCL who received ≥2 prior therapies were stratified by DLBCL subtype [germinal center B-cell (GCB) vs. non-GCB; determined by immunohistochemistry (IHC)] and then randomized 1:1 to lenalidomide (25 mg/day, 21 days of 28-day cycle) or IC (gemcitabine, rituximab, etoposide, or oxaliplatin). Crossover to lenalidomide was permitted for IC-treated patients with radiologically confirmed progressive disease. The primary endpoint was overall response rate (ORR). Progression-free survival (PFS), overall survival, and subtype analysis [GCB vs. activated B-cell (ABC)] using gene expression profiling (GEP) were exploratory endpoints.Results: Stage 1: 102 DLBCL patients (by IHC: non-GCB, n = 54; GCB, n = 48) received ≥1 dose of lenalidomide or IC. Hematologic treatment-emergent adverse events with lenalidomide versus IC included neutropenia (42.6%; 36.4%), anemia (33.3%; 47.3%), thrombocytopenia (24.1%; 43.6%), and leukopenia (5.6%; 12.7%), respectively. Overall, lenalidomide-treated patients had an ORR of 27.5% versus 11.8% in IC (ORRs were similar regardless of IHC-defined DLBCL subtype). Median PFS was increased in patients receiving lenalidomide (13.6 weeks) versus IC (7.9 weeks; P = 0.041), with greater improvements in non-GCB patients (15.1 vs. 7.1 weeks, respectively; P = 0.021) compared with GCB (10.1 vs. 9.0 weeks, respectively; P = 0.550).Conclusions: The clinical benefit of lenalidomide monotherapy in DLBCL patients was more evident in the non-GCB subtype. Exploratory analyses suggest that this preferential benefit was more pronounced in the GEP-defined ABC population, demonstrating a need for additional studies of lenalidomide in DLBCL using GEP subtyping. Clin Cancer Res; 1-11. ©2017 AACR.
title: Real-Time Mammography Dose Monitoring and Optimisation using Big Data
Creators: name: Tromans, Christopher
Publisher: name: ESR EuroSafe Imaging
Year: 2016
Subjects: subject: Action 8 - EuroSafe Imaging Stars network and data collection
subject: Action 3 - Optimisation, diagnostic reference levels, image quality
subject: Action 2 - Clinical audit
subject: Action 6 - Clinical audit tool for imaging
subject: Action 2 - Clinical diagnostic reference levels (DRLs)
subject: Action 10 - EuroSafe Imaging Stars

description: Background/Introduction Description of activity and work performed Conclusion and Recommendations Personal/Organisational information References
description: Background/Introduction: X-ray mammography is the primary tool for screening the female population for breast cancer. Since the vast majority of participants are completely healthy, the ALARA principal, "As Low As Reasonably Achievable", is of paramount importance....
Evolution of an Early Titan Atmosphere: Comment
Creators: name: Johnson, Robert E
name: Tucker, Orenthal J.
name: Volkov, Alexey N.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Escape of an early atmosphere from Titan, during which time NH3 could be converted by photolysis into the present N2 dominated atmosphere, is an important problem in planetary science. Recently Gilliam and Lerman (2014) estimated escape driven by the surface temperature and pressure, which we show gave loss rates that are orders of magnitude too large. Their model, related to Jeans escape from an isothermal atmosphere, was used to show that escape driven only by surface heating would deplete the atmospheric inventory of N for a suggested Titan accretion temperature of ~355 K. Therefore, they concluded that the accretion temperature must be lower in order to retain the present Titan atmosphere. Here we show that the near surface atmospheric temperature is essentially irrelevant for determining the atmospheric loss rate from Titan and that escape is predominantly driven by solar heating of the upper atmosphere. We also give a rough estimate of the escape rate in the early solar system (~10^4 kg/s) consistent with an inventory of nitrogen being available over the time period suggested by Atreya et al. (1978) for conversion of NH3 into N2.
description: 6 pages
title: Dose of ionising radiation for patients during transarterial chemoembolisation (TACE)
Creators: name: Feldbergs, Davis
name: Radzina, Maija
Publisher: name: ESR EuroSafe Imaging
Year: 2016
Subjects: subject: Action 10 - Improved communication and collaboration of health professionals in radiation protection
subject: Action 8 - EuroSafe Imaging Stars network and data collection
subject: Action 3 - Optimisation, diagnostic reference levels, image quality
subject: Action 2 - Clinical diagnostic reference levels (DRLs)
subject: Action 10 - EuroSafe Imaging Stars
subject: Action 13 - Stakeholder engagement and collaboration

description: Background/Introduction Description of activity and work performed Conclusion and Recommendations Personal/Organisational information References
description: Background/Introduction: Transarterial chemoembolisation (TACE) is a minimally invasive procedure performed in interventional radiology to restrict a tumor’s blood supply. This type of treatment affects cancer in two ways: first - the chemical substance is delivered in...
A Phase I, Dose Escalation Study of Oral ASP8273 in Patients with Non–small Cell Lung Cancers with Epidermal Growth Factor Receptor Mutations
Creators: name: Desai, Bhardwaj
name: Spira, Alexander
name: Moran, Diarmuid
name: Keating, Anne
name: Weiss, Jared
name: Evans, Tracey
name: Kelly, Ronan J.
name: Jie, Fei
name: Aoyama, Kouji
name: West, Howard
name: Yu, Helena A.
name: Poondru, Srinivasu
name: Oxnard, Geoffrey R.
name: Giaccone, Giuseppe
name: Horn, Leora
name: Krivoshik, Andrew
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Purpose: Acquired EGFR T790M mutations are the most frequently identified resistance mechanism to EGFR tyrosine kinase inhibitors (TKI) in patients with EGFR-mutant lung cancers. ASP8273 is a third-generation EGFR TKI with antitumor activity in preclinical models of EGFR-mutant lung cancer that targets mutant EGFR, including EGFR T790M.Experimental Design: In this multicohort, phase I study (NCT02113813), escalating doses of ASP8273 (25-500 mg) were administered once daily to non-small cell lung cancer (NSCLC) patients with disease progression after prior treatment with an EGFR TKI. EGFR T790M was required for all cohorts, except the dose escalation cohort. Primary endpoints were safety/tolerability; secondary endpoints were determination of the RP2D, pharmacokinetic profile, and preliminary antitumor activity of ASP8273. Evaluation of the use of EGFR mutations in circulating free DNA (cfDNA) as a biomarker of ASP8273 treatment effects was an exploratory endpoint.Results: A total of 110 patients were treated with ASP8273 across dose escalation (n = 36), response-expansion (n = 36), RP2D (300 mg; n = 19) and food-effect (n = 19) cohorts. The most common treatment-emergent adverse events included diarrhea, nausea, fatigue, constipation, vomiting, and hyponatremia. Across all doses, in patients with EGFR T790M, the response rate was 30.7% (n = 27/88; 95% CI, 19.5%-44.5%), and median progression-free survival was 6.8 months (95% CI, 5.5-10.1 months). EGFR mutations in cfDNA, both the activating mutation and EGFR T790M, became undetectable in most patients in the setting of clinical response and reemerged upon disease progression.Conclusions: ASP8273 was well tolerated and promoted antitumor activity in patients with EGFR-mutant lung cancer with disease progression on prior EGFR TKI therapy. Clin Cancer Res; 23(24); 7467-73. ©2017 AACR.
Study Protocol: ChatGPT-generated versus expert-written answers to frequently asked questions about diabetes - an e-survey among all employees of a Danish diabetes center
Creators: name: Hulman, Adam
name: Dollerup, Ole Lindgård
name: Mortensen, Jesper Friis
name: Norman, Kasper
name: Støvring, Henrik
name: Hansen, Troels Krarup
Publisher: name: figshare
Year: 2023
Subjects: Endocrinology
Artificial intelligence not elsewhere classified

description: The aim of the study was to investigate ChatGPT’s knowledge in the diabetes domain, more specifically in response to potential questions asked by patients about the disease, medication, diet and physical activity. We hypothesized that participants (employees at a regional diabetes center: Steno Diabetes Center Aarhus), who have at least some and up to expert knowledge about diabetes, will not be able to distinguish between answers written by humans and generated by AI in response to diabetes-related questions. Our secondary hypothesis is that people with contact to patients as caregivers and those who previously tried ChatGPT might be better at identifying answers generated by AI. The survey was developed in Danish. The document is a study protocol including details according to the CHERRIES checklist for e-surveys.