cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Surveillance for neuraminidase inhibitor resistance among human influenza A and B viruses circulating worldwide from 2004 to 2008
Creators: name: Garten, R.J.
name: Klimov, A.I.
name: Butler, E.N.
name: Gubareva, L.V.
name: Okomo-Adhiambo, M.
name: Bright, R.A.
name: Deyde, V.M.
name: Wallis, T.R.
name: Xu, X.
name: Sheu, T.G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The surveillance of seasonal influenza virus susceptibility to neuraminidase (NA) inhibitors was conducted using an NA inhibition assay. The 50% inhibitory concentration values (IC50S) of 4,570 viruses collected globally from October 2004 to March 2008 were determined. Based on mean IC50S, A(H3N2) viruses (0.44 nM) were more sensitive to oseltamivir than A(H1N1) viruses (0.91 nM). The opposite trend was observed with zanamivir: 1.06 nM for A(H1N1) and 2.54 nM for A(H3N2). Influenza B viruses exhibited the least susceptibility to oseltamivir (3.42 nM) and to zanamivir (3.87 nM). To identify potentially resistant viruses (outliers), a threshold of a mean IC50 value + 3 standard deviations was defined for type/subtype and drug. Sequence analysis of outliers was performed to identify NA changes that might be associated with reduced susceptibility. Molecular markers of oseltamivir resistance were found in six A(H1N1) viruses (H274Y) and one A(H3N2) virus (E119V) collected between 2004 and 2007. Some outliers contained previously reported mutations (e.g., I222T in the B viruses), while other mutations [e.g., R371K and H274Y in B viruses and H274N in A(H3N2) viruses) were novel. The R371K B virus outlier exhibited high levels of resistance to both inhibitors (>100 nM). A substantial variance at residue D151 was observed among A(H3N2) zanamivir-resistant outliers. The clinical relevance of newly identified NA mutations is unknown. A rise in the incidence of oseltamivir resistance in A(H1N1) viruses carrying the H274Y mutation was detected in the United States and in other countries in the ongoing 2007 to 2008 season. As of March 2008, the frequency of resistance among A(H1N1) viruses in the United States was 8.6% (50/579 isolates). The recent increase in oseltamivir resistance among A(H1N1) viruses isolated from untreated patients raises public health concerns and necessitates close monitoring of resistance to NA inhibitors.
Floquet interface states in illuminated three-dimensional topological insulators
Creators: name: Calvo, H. L.
name: Torres, L. E. F. Foa
name: Perez-Piskunow, P. M.
name: Balseiro, C. A.
name: Usaj, Gonzalo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Recent experiments showed that the surface of a three dimensional topological insulator develops gaps in the Floquet-Bloch band spectrum when illuminated with a circularly polarized laser. These Floquet-Bloch bands are characterized by non-trivial Chern numbers which only depend on the helicity of the polarization of the radiation field. Here we propose a setup consisting of a pair of counter-rotating lasers, and show that one-dimensional chiral states emerge at the interface between the two lasers. These interface states turn out to be spin-polarized and may trigger interesting applications in the field of optoelectronics and spintronics.
description: 5 pages with 3 figures + supplemental material
Risk-adjusted models for adverse obstetric outcomes and variation in risk-adjusted outcomes across hospitals
Creators: name: Saade, George
name: Grobman, William A.
name: Thorp, John M.
name: Tolosa, Jorge E.
name: Sorokin, Yoram
name: Caritis, Steve N.
name: Shubert, Phillip J.
name: Rice, Madeline Murguia
name: Blackwell, Sean C.
name: Spong, Catherine Y.
name: Wapner, Ronald J.
name: Bailit, Jennifer L.
name: Leveno, Kenneth J.
name: Tita, Alan T.
name: Varner, Michael W.
name: Van Dorsten, J. Peter
name: Rouse, Dwight J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Regulatory bodies and insurers evaluate hospital quality using obstetrical outcomes, however meaningful comparisons should take pre-existing patient characteristics into account. Furthermore, if risk-adjusted outcomes are consistent within a hospital, fewer measures and resources would be needed to assess obstetrical quality. Our objective was to establish risk-adjusted models for five obstetric outcomes and assess hospital performance across these outcomes.
Additional file 2: of Comparison of the source and prognostic utility of cfDNA in trauma and sepsis
Creators: name: Chornenki, Nicholas Jackson
name: Coke, Robert
name: Kwong, Andrew
name: Dhruva Dwivedi
name: Xu, Michael
name: McDonald, Ellen
name: Marshall, John
name: Fox-Robichaud, Alison
name: Charbonney, Emmanuel
name: Liaw, Patricia
Publisher: name: Figshare
Year: 2019
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Marine Biology

description: Table S2. Comparison of methods of cfDNA quantification. (DOCX 17 kb)
Hyper-Kähler with Torsion, T-duality, and Defect (p,q) Five-branes
Creators: name: Kimura, Tetsuji
name: Sasaki, Shin
name: Yata, Masaya
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We investigate a five-branes interpretation of hyper-Kähler geometry with torsion (HKT). This geometry is obtained by conformal transformation of the Taub-NUT space which represents a Kaluza-Klein five-brane. This HKT would represent an NS5-brane on the Taub-NUT space. In order to explore the HKT further, we compactify one transverse direction, and study the $O(2,2;{\mathbb Z}) = SL(2,{\mathbb Z}) \times SL(2,{\mathbb Z})$ monodromy structure associated with two-torus. Performing the conjugate transformation, we obtain a new solution whose physical interpretation is a defect $(p,q)$ five-brane on the ALG space. Throughout this analysis, we understand that the HKT represents a coexistent state of two kinds of five-branes. This situation is different from composite states such as $(p,q)$ five-branes or $(p,q)$ seven-branes in type IIB theory. We also study the T-dualized system of the HKT. We again find a new solution which also indicates another defect $(p,q)$ five-brane on the ALG space.
description: 21 pages, version published in JHEP
Rückführung von Gewindemessgrößen : Expertenbericht DKD-E 4-1
Creators: name: Fachausschuss Länge Des DKD
Publisher: name: Physikalisch-Technische Bundesanstalt (PTB)
Year: 2022
Subjects: DKD-Expertenbericht
Gewindemessgrößen
Flankendurchmesser
Paarungsflankendurchmesser
Außendurchmesser
Kerndurchmesser
Teilung
Steigung
Gewindeprofilwinkel
Gewindeflankenwinkel

description: In der Qualitätssicherung der Gewindeproduktion spielt die Messtechnik eine wesentliche Rolle. Während die Prüfung von Werkstückgewinden typischerweise durch Lehren erfolgt, müssen die verwendeten Lehrdorne und -ringe zuvor mit geeigneten Messverfahren kalibriert werden. Derzeit sind in Deutschland 47 Kalibrierlaboratorien für Gewindemessgrößen durch die DAkkS akkreditiert. Die Kalibrierung von Gewindelehren durch diese Laboratorien ist über die PTB oder ein anderes Nationales Metrologieinstitut auf das Internationale Einheitensystem (SI) metrologisch rückgeführt. Die seitens der Industrie stets wachsende Forderung nach genauerer Messtechnik zur Sicherstellung einer steigenden Produktionsqualität mit immer kleineren Fertigungstoleranzen hat auch in der Gewindemesstechnik in den vergangenen Dekaden zur Entwicklung innovativer Messverfahren geführt. So werden etablierte Methoden wie das Dreidraht- und Zweikugelverfahren mittlerweile vielerorts durch Tastschnittverfahren und Koordinatenmessungen ergänzt. Darüber hinaus existieren Ansätze auf der Grundlage optischer oder anderer berührungsloser Sensoren. Die Vielfalt der verfügbaren Messverfahren verlangt dabei in besonderer Weise nach Harmonisierung, weil sichergestellt werden muss, dass verschiedene Methoden vergleichbare Messergebnisse liefern. Dabei stellt sich heraus, dass die Schwierigkeiten bereits bei der Definition von Bestimmungsgrößen anfangen, die für alle Messverfahren gleichermaßen eindeutig und zugänglich sein müssen. Die messtechnischen Grundlagen und Prüfanweisungen für zylindrische Gewindedorne und ringe sind in den Richtlinien VDI/VDE/DGQ 2618 Blatt 4.8 und 4.9: 2006-04 beschrieben. Eine ausführliche Darstellung der Vorgehensweise zur Bestimmung des Flankendurchmessers mit der Dreidraht- und Zweikugelmethode nach Berndt sowie Kochsiek und Lerch findet sich in EURAMET cg-10:2012-12. Die genannten Richtlinien sind in ihrer Anwendung explizit auf zylindrische Gewinde beschränkt. Außerdem enthalten sie eher technische Details zur Messung und Berechnung der Bestimmungsgrößen als grundsätzliche Aussagen zur Realisierung einer zuverlässigen und aufgabenspezifischen Rückführung. Dieser Bericht gilt für ein- und mehrgängige zylindrische und kegelige Gewindedorne und ringe mit geradlinigen Flanken und positiven Flankenwinkeln. Er soll einen vertiefenden Überblick über die Anforderungen geben, die an verlässliche und metrologisch rückgeführte Gewindemessungen gestellt werden müssen, um die Vergleichbarkeit sowohl zwischen verschiedenen Laboratorien als auch bei Verwendung unterschiedlicher Messverfahren sicherzustellen.
Sling revision/removal for mesh erosion and urinary retention: long-term risk and predictors
Creators: name: Siddiqui, Nazema Y.
name: Wu, Jennifer M.
name: Jonsson Funk, Michele
name: Pate, Virginia
name: Amundsen, Cindy L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: To estimate the long-term risk of sling revision/removal after an initial sling and to assess indications (mesh erosion and urinary retention) and predictors of sling revision/removal.
Maternal periconceptional alcohol consumption and gastroschisis in the National Birth Defects Prevention Study, 1997–2011
Creators: name: Romitti, P.A.
name: Fisher, S.C.
name: Howley, M.M.
name: Browne, M.L.
name: Desrosiers, T.A.
name: Jabs, E.W.
name: National Birth Defects Prevention Study
Publisher: name: John Wiley and Sons Inc
Year: 2022

description: Background: Gastroschisis is particularly prevalent among offspring of young women and has increased over recent decades. Although previous studies suggest that maternal alcohol consumption is associated with increased gastroschisis risk, none have explored whether maternal age modifies that association. Objective: The objective of the study was to evaluate associations between self-reported maternal periconceptional alcohol consumption (1 month prior through the third month after conception) and risk of gastroschisis among offspring, by maternal age. Methods: We used data from the National Birth Defects Prevention Study (NBDPS), a multi-site population-based case-control study. The analysis included 1450 gastroschisis cases and 11,829 unaffected liveborn controls delivered during 1997–2011 in ten US states. We estimated adjusted odds ratios (aOR) and 95% confidence intervals (CI) for the individual and joint effects of alcohol consumption and young maternal age at delivery (<25 years vs ≥25 years) on gastroschisis risk. We estimated the relative excess risk due to interaction (RERI) to quantify additive interaction. Results: Periconceptional alcohol consumption was common regardless of maternal age (women <25 years: cases 38.8%, controls 29.3%; women ≥25: cases 43.5%, controls 39.5%). Compared with women ≥25 years who did not consume alcohol, we observed increased risk of gastroschisis among women <25 years, with higher estimates among those who consumed alcohol (women <25 years who did not consume alcohol. aOR 5.90, 95% CI 4.89, 7.11; women <25 years who did consume alcohol: aOR 8.21, 95% CI 6.69, 10.07). Alcohol consumption among women ≥25 years was not associated with gastroschisis (aOR 1.12, 95% CI 0.88, 1.42). This suggests super-additive interaction between alcohol consumption and maternal age (RERI −2.19, 95% CI 1.02, 3.36). Conclusions: Periconceptional alcohol consumption may disproportionately increase risk of gastroschisis among young mothers. Our findings support public health recommendations to abstain from alcohol consumption during pregnancy.
The association of cerebral palsy and death with small-for-gestational-age birthweight in preterm neonates by individualized and population-based percentiles
Creators: name: Spong, Catherine Y.
name: Malone, Fergal D.
name: Leveno, Kenneth J.
name: Lai, Yinglei
name: Thorp, John M.
name: Iams, Jay D.
name: Ramin, Susan M.
name: Hankins, Gary D.V.
name: Sorokin, Yoram
name: Mercer, Brian M.
name: Caritis, Steve N.
name: Rouse, Dwight J.
name: O'Sullivan, Mary J.
name: Grobman, William A.
name: Wapner, Ronald J.
name: Varner, Michael W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: To determine whether an individualized growth standard (IS) improves identification of preterm small-for-gestational-age (SGA) neonates at risk of developing moderate/severe cerebral palsy (CP) or death.
Evaluating Teacher Access to Online Professional Development: Establishing Access Patterns from User and Server Analytics
Creators: name: Leung, Javier
Publisher: name: figshare
Year: 2022
Subjects: subject: 170103 Educational Psychology
subject: FOS: Psychology
subject: 130306 Educational Technology and Computing
subject: FOS: Educational sciences
subject: 130108 Technical, Further and Workplace Education

description: The COVID-19 pandemic has forced K-12 schools to seek professional development with online resources that address their professional needs while keeping health and safety in mind. In Missouri, approximately 250 school districts in the Network for Educator Effectiveness (NEE) have 24/7 access to the EdHub Library that provides more than 500 online self-paced professional development resources (Network for Educator Effectiveness, n.d.-a). Due to the pandemic, the EdHub Library has seen increased web traffic; this study identifies the most accessed resources by analyzing user and server web analytics to improve resource access. This study also identifies resource access patterns using the Apriori algorithm for association rule mining. The results pointed out that approximately 40% of the web traffic occurred among the EdHub Library homepage, Dyslexia activities, and resource page for Teaching Standard 1 (i.e., Content Knowledge and Appropriate Instruction). Along with the findings, recommendations for resource optimization by the Word Wide Web Consortium (W3C) are explored. The visualizations can be found on Tableau Public (Leung, n.d.).
Basalt fiber composites for the robotic fabrication of a lunar habitat
Creators: name: Cheibas, Ina
name: Arnhof, Marlies
name: Riches, Belinda
Publisher: name: figshare
Year: 2022
Subjects: subject: 100605 Performance Evaluation; Testing and Simulation of Reliability
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: 120403 Engineering Design Methods
subject: FOS: Other engineering and technologies

description: This study investigates the mechanical properties of a novel composite for a lunar space habitat. The research aims to identify high-mechanical strength materials for a robotically fabricated habitat with in-situ resources. Several basalt fiber types and cementitious matrices were investigated for building a fiber-reinforced composite. The effect of the basalt fiber type - chopped, spooled, and long; and fiber percentage - 1 wt. %, 5 wt. %, and 10 wt. %; was investigated. The samples were initially exposed to a maximum lunar environmental temperature of 117°C and a medium vacuum of 0.01 atm for 24 hours. Then, these samples were tested after curing for flexural and compressive strengths until failure and cracking occurred. The 10% chopped basalt fiber and the 5% long basalt fiber composite proved the most promising combination for a high-mechanical strength composite. These composites demonstrated an improved compressive and flexural strength for the cement slurry. Moreover, this study enables the robotic fabrication potential of a mechanically resilient lunar habitat.
Use of antihistamine medications during early pregnancy and selected birth defects: The National Birth Defects Prevention Study, 1997–2011
Creators: name: Strickland, M.J.
name: Gilboa, S.M.
name: Wisniewski, K.
name: Werler, M.M.
name: Desrosiers, T.
name: Hansen, C.
Publisher: name: John Wiley and Sons Inc
Year: 2020

description: Background: It is estimated that approximately 10–15% of pregnant women report antihistamine use during pregnancy. Although antihistamines are generally considered safe during pregnancy, results from published studies are inconsistent. Methods: Using a case–control study design we analyzed 41,148 pregnancies (30,091 cases and 11,057 controls) from the National Birth Defects Prevention Study (1997–2011). Logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals for 64 birth defect groupings in relation to early pregnancy exposure to 14 distinct antihistamines. Models were adjusted for maternal age, race, parity, education level, prenatal care, folic acid use, smoking and alcohol use, and study site. Results: Approximately 13% of cases and controls were exposed to an antihistamine during early pregnancy. Analyses were restricted to those defects where more than five cases were exposed to the antihistamine of interest, generating 340 analyses which yielded 20 (5.9%) significant positive associations (adjusted ORs ranging from 1.21 to 4.34). Conclusions: Only a few of our findings were consistent with previous studies. There is a lack of strong evidence to conclude that birth defects are associated with exposure to antihistamines during early pregnancy.
The impact of uterine leiomyomas: a national survey of affected women
Creators: name: Stewart, Elizabeth A.
name: Bradley, Linda
name: Borah, Bijan J.
name: Nicholson, Wanda K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: To characterize the impact of uterine leiomyomas (fibroids) in a racially diverse sample of women in the United States.
Trends in use of surgical mesh for pelvic organ prolapse
Creators: name: Pate, Virginia
name: Visco, Anthony G.
name: Edenfield, Autumn L.
name: Weidner, Alison C.
name: Jonsson Funk, Michele
name: Wu, Jennifer M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Limited data exist on the rates of pelvic organ prolapse procedures utilizing mesh. The objective of this study was to examine trends in vaginal mesh prolapse procedures (VM), abdominal sacrocolpopexy (ASC) and minimally-invasive sacrocolpopexy (MISC) from 2005–2010.
Is residential proximity to polluted sites during pregnancy associated with preterm birth or low birth weight? Results from an integrated exposure database in North Carolina (2003–2015)
Creators: name: Luben, T.J.
name: Forestieri, N.
name: Desrosiers, T.A.
name: Keeler, C.
name: Olshan, A.F.
Publisher: name: Springer Nature
Year: 2023

description: Background: Preterm birth (PTB) and term low birth weight (LBW) have been associated with pollution and other environmental exposures, but the relationship between these adverse outcomes and specific characteristics of polluted sites is not well studied. Objectives: We conducted a retrospective cohort study to examine relationships between residential proximity to polluted sites in North Carolina (NC) and PTB and LBW. We further stratified exposure to polluted sites by route of contaminant emissions and specific contaminants released at each site. Methods: We created an integrated exposure geodatabase of polluted sites in NC from 2002 to 2015 including all landfills, Superfund sites, and industrial sites. Using birth certificates, we assembled a cohort of 1,494,651 singleton births in NC from 2003 to 2015. We geocoded the gestational parent residential address on the birth certificate, and defined exposure to polluted sites as residence within one mile of a site. We used log-binomial regression models to estimate adjusted risk ratios (aRR) and 95% confidence intervals (CI). Binomial models were used to estimate adjusted risk differences (aRD) per 10,000 births and 95% CIs for associations between exposure to polluted sites and PTB or LBW. Results: We observed weak associations between residential proximity to polluted sites and PTB [aRR(95% CI): 1.07(1.06,1.09); aRD(95% CI): 61(48,74)] and LBW [aRR(95% CI): 1.09(1.06,1.12); aRD(95% CI): 24(17,31)]. Secondary analyses showed increased risk of both PTB and LBW among births exposed to sites characterized by water emissions, air emissions, and land impoundment. In analyses of specific contaminants, increased risk of PTB was associated with proximity to sites containing arsenic, benzene, cadmium, lead, mercury, and polycyclic aromatic hydrocarbons. LBW was associated with exposure to arsenic, benzene, cadmium, lead, and mercury. Significance: This study provides evidence for potential reproductive health effects of polluted sites, and underscores the importance of accounting for heterogeneity between polluted sites when considering these exposures. Impact statement: We documented an overall increased risk of both PTB and LBW in births with gestational exposure to polluted sites using a harmonized geodatabase of three site types, and further examined exposures stratified by site characteristics (route of emission, specific contaminants present). We observed increased risk of both PTB and LBW among births exposed to sites with water emissions or air emissions, across site types. Increased risk of PTB was associated with gestational proximity to sites containing arsenic, benzene, cadmium, lead, mercury, and polycyclic aromatic hydrocarbons; increased risk of LBW was associated with exposure to arsenic, benzene, cadmium, lead, and mercury.
Is maternal employment site a source of exposure misclassification in studies of environmental exposures and birth outcomes? A simulation-based bias analysis of haloacetic acids in tap water and hypospadias
Creators: name: Reefhuis, J.
name: Engel, L.S.
name: Keil, A.P.
name: Langlois, P.H.
name: Zaganjor, I.
name: Michalski, A.M.
name: Olshan, A.F.
name: The National Birth Defects Prevention Study
name: Luben, T.J.
name: Desrosiers, T.A.
Publisher: name: Wolters Kluwer Health
Year: 2022

description: Background: In population research, exposure to environmental contaminants is often indirectly assessed by linking residence to geocoded databases of environmental exposures. We explored the potential for misclassification of residence-based environmental exposure as a result of not accounting for the workplace environments of employed pregnant women using data from a National Birth Defects Prevention Study (NBDPS) analysis of drinking water haloacetic acids and hypospadias. Methods: The original analysis used NBDPS data from women with haloacetic acid exposure information in eight states who delivered an infant with second- or third-degree hypospadias (cases) or a male infant without a birth defect (controls) between 2000 and 2005. In this bias analysis, we used a uniform distribution to randomly select 11%-14% of employed women that were assumed to change municipal water systems between home and work and imputed new contaminant exposures for tap water beverages consumed at work among the selected women using resampled values from the control population. Multivariable logistic regression was used to estimate the association between hypospadias and haloacetic acid ingestion with the same covariates and exposure cut-points as the original study. We repeated this process across 10,000 iterations and then completed a sensitivity analysis of an additional 10,000 iterations where we expanded the uniform distribution (i.e., 0%, 28%). Results: In both simulations, the average results of the 10,000 iterations were nearly identical to those of the initial study. Conclusions: Our results suggest that household estimates may be sufficient proxies for worksite exposures to haloacetic acids in tap water.
Oxygen emission in remnants of thermonuclear supernovae as a probe for their progenitor system
Creators: name: Kosenko, D.
name: Hillebrandt, W.
name: Kromer, M.
name: Blinnikov, S. I.
name: Pakmor, R.
name: Kaastra, J. S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Recent progress in numerical simulations of thermonuclear supernova explosions brings up a unique opportunity in studying the progenitors of Type Ia supernovae. Coupling state-of-the-art explosion models with detailed hydrodynamical simulations of the supernova remnant evolution and the most up-to-date atomic data for X-ray emission calculations makes it possible to create realistic synthetic X-ray spectra for the supernova remnant phase. Comparing such spectra with high quality observations of supernova remnants could allow to constrain the explosion mechanism and the progenitor of the supernova. The present study focuses in particular on the oxygen emission line properties in young supernova remnants, since different explosion scenarios predict a different amount and distribution of this element. Analysis of the soft X-ray spectra from supernova remnants in the Large Magellanic Cloud and confrontation with remnant models for different explosion scenarios suggests that SNR 0509-67.5 could originate from a delayed detonation explosion and SNR 0519-69.0 from an oxygen-rich merger.
description: 8 pages, 4 figures, MNRAS accepted
Association of cord blood digitalis-like factor and necrotizing enterocolitis
Creators: name: Ramin, Susan M.
name: O'Sullivan, Mary J.
name: Rouse, Dwight J.
name: Leveno, Kenneth J.
name: Iams, Jay D.
name: Hankins, Gary D.V.
name: Graves, Steven W.
name: Sorokin, Yoram
name: Wapner, Ronald J.
name: Peaceman, Alan M.
name: Dudley, Donald J.
name: Mercer, Brian M.
name: Malone, Fergal D.
name: Thorp, John M.
name: McGee, Paula
name: Caritis, Steven N.
name: Esplin, Michael S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Endogenous digoxin-like factor (EDLF) has been linked to vasoconstriction, altered membrane transport and apoptosis. Our objective was to determine whether increased EDLF in the cord sera of preterm infants was associated with an increased incidence of necrotizing enterocolitis (NEC).
Advantages and challenges in coupling an ideal gas to atomistic models in adaptive resolution simulations
Creators: name: Kreis, Karsten
name: Fogarty, Aoife C.
name: Kremer, Kurt
name: Potestio, Raffaello
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: In adaptive resolution simulations, molecular fluids are modeled employing different levels of resolution in different subregions of the system. When traveling from one region to the other, particles change their resolution on the fly. One of the main advantages of such approaches is the computational efficiency gained in the coarse-grained region. In this respect the best coarse-grained system to employ in the low resolution region would be the ideal gas, making intermolecular force calculations in the coarse-grained subdomain redundant. In this case, however, a smooth coupling is challenging due to the high energetic imbalance between typical liquids and a system of non-interacting particles. In the present work, we investigate this approach, using as a test case the most biologically relevant fluid, water. We demonstrate that a successful coupling of water to the ideal gas can be achieved with current adaptive resolution methods, and discuss the issues that remain to be addressed.
Can differences in obstetric outcomes be explained by differences in the care provided? The MFMU Network APEX study
Creators: name: Rouse, Dwight J.
name: Bailit, Jennifer L.
name: Saade, George
name: Iams, Jay D.
name: Van Dorsten, J. Peter
name: Leveno, Kenneth J.
name: Tolosa, Jorge E.
name: Grobman, William A.
name: Sorokin, Yoram
name: Tita, Alan T.
name: Wapner, Ronald J.
name: Thorp, John M.
name: Varner, Michael W.
name: Caritis, Steve N.
name: Rice, Madeline Murguia
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: To determine whether hospital differences in the frequency of adverse obstetric outcomes are related to differences in care.
Recharge saisonnière de sondes géothermiques
Creators: name: Pahud Daniel
name: Emile, Martin
name: Jobard Xavier
name: Dami Josquin
Publisher: name: Zenodo
Year: 2022
Subjects: Borehole heat exchanger
borehole field
active thermal recharge
seasonal heat storage
heat pump
aero-convector

description: Analysis of a monitored geothermal heat pump coupled to a field of borehole heat exchangers recharged with an outdoor aero-convector. The project dealt with 2 years of detailed system monitoring, system optimisation, system simulation and calibration. Extensive system simulations lead to thermal characterisation and design guidelines of active recharge solutions based on aero-convectors or solar absorbers. Comparisons based on thermal performances and economic data were made.
Dark matter and dark energy from Bose-Einstein condensate
Creators: name: Das, Saurya
name: Bhaduri, Rajat K.
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We show that Dark Matter consisting of bosons of mass of about 1eV or less has critical temperature exceeding the temperature of the universe at all times, and hence would have formed a Bose-Einstein condensate at very early epochs. We also show that the wavefunction of this condensate, via the quantum potential it produces, gives rise to a cosmological constant which may account for the correct dark energy content of our universe. We argue that massive gravitons or axions are viable candidates for these constituents. In the far future this condensate is all that remains of our universe.
description: 4 pages, 1 figure. References added and updated. Note added. Version to appear in Classical and Quantum Gravity
Delivery timing and cesarean delivery risk in women with mild gestational diabetes mellitus
Creators: name: Sciscione, Anthony
name: Varner, Michael W.
name: Mele, Lisa
name: Caritis, Steve N.
name: Saade, George
name: Grobman, William A.
name: Catalano, Patrick
name: Sutton, Amelia L.
name: Harper, Margaret
name: Thorp, John M.
name: Ramin, Susan M.
name: Sorokin, Yoram
name: Landon, Mark B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: To evaluate the relationship between gestational age (GA) and induction of labor (IOL) and the rate of cesarean delivery (CD) in women with mild gestational diabetes (GDM).
Link homology and equivariant gauge theory
Creators: name: Poudel, Prayat
name: Saveliev, Nikolai
Publisher: name: arXiv
Year: 2015
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 57M27 57R58

description: The singular instanton Floer homology was defined by Kronheimer and Mrowka in connection with their proof that the Khovanov homology is an unknot detector. We study this theory for knots and two-component links using equivariant gauge theory on their double branched covers. We show that the special generator in the singular instanton Floer homology of a knot is graded by the knot signature mod 4, thereby providing a purely topological way of fixing the absolute grading in the theory. Our approach also results in explicit computations of the generators and gradings of the singular instanton Floer chain complex for several classes of knots with simple double branched covers, such as two-bridge knots, torus knots, and Montesinos knots, as well as for several families of two-components links.
description: 59 pages. Corrected a grading error in Lemma 2.5, which affected calculations for some of the knots
Cancer diagnostic profile in children with structural birth defects: An assessment in 15,000 childhood cancer cases
Creators: name: Plon, S.E.
name: Schraw, J.M.
name: Desrosiers, T.
name: Nembhard, W.N.
name: Langlois, P.H.
name: Spector, L.G.
name: Meyer, R.E.
name: Canfield, M.A.
name: Lupo, P.J.
name: Rasmussen, S.A.
name: Chambers, T.M.
Publisher: name: John Wiley and Sons Inc.
Year: 2020

description: Background: Birth defects are established risk factors for childhood cancer. Nonetheless, cancer epidemiology in children with birth defects is not well characterized. Methods: Using data from population-based registries in 4 US states, this study compared children with cancer but no birth defects (n = 13,111) with children with cancer and 1 or more nonsyndromic birth defects (n = 1616). The objective was to evaluate cancer diagnostic characteristics, including tumor type, age at diagnosis, and stage at diagnosis. Results: Compared with the general population of children with cancer, children with birth defects were diagnosed with more embryonal tumors (26.6% vs 18.7%; q < 0.001), including neuroblastoma (12.5% vs 8.2%; q < 0.001) and hepatoblastoma (5.0% vs 1.3%; q < 0.001), but fewer hematologic malignancies, including acute lymphoblastic leukemia (12.4% vs 24.4%; q < 0.001). In age-stratified analyses, differences in tumor type were evident among children younger than 1 year and children 1 to 4 years old, but they were attenuated among children 5 years of age or older. The age at diagnosis was younger in children with birth defects for most cancers, including leukemia, lymphoma, astrocytoma, medulloblastoma, ependymoma, embryonal tumors, and germ cell tumors (all q < 0.05). Conclusions: The results indicate possible etiologic heterogeneity in children with birth defects, have implications for future surveillance efforts, and raise the possibility of differential cancer ascertainment in children with birth defects. Lay Summary: Scientific studies suggest that children with birth defects are at increased risk for cancer. However, these studies have not been able to determine whether important tumor characteristics, such as the type of tumor diagnosed, the age at which the tumor is diagnosed, and the degree to which the tumor has spread at the time of diagnosis, are different for children with birth defects and children without birth defects. This study attempts to answer these important questions. By doing so, it may help scientists and physicians to understand the causes of cancer in children with birth defects and diagnose cancer at earlier stages when it is more treatable.
Dalitz plot analyses of $B^0 \to D^- D^0 K^+$ and $B^+ \to \overline{D}^0 D^0 K^+$ decays
Creators: name: The BABAR Collaboration
name: Lees, J. P.
name: Others
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We present Dalitz plot analyses for the decays of $B$ mesons to $D^- D^0 K^+$ and $\overline{D}^0 D^0 K^+$. We report the observation of the $D^{*}_{s1}(2700)^+$ resonance in these two channels and obtain measurements of the mass $M(D^{*}_{s1}(2700)^+) = 2699 {}^{+14}_{-7} \, \mathrm{MeV}/c^2$ and of the width $Γ(D^{*}_{s1}(2700)^+) = 127 {}^{+24}_{-19} \, \mathrm{MeV}$, including statistical and systematic uncertainties. In addition, we observe an enhancement in the $D^0K^+$ invariant mass around 2350--2500 MeV/$c^2$ in both decays $B^0 \to D^- D^0 K^+$ and $B^+ \to \overline{D}^0 D^0 K^+$, which we are not able to interpret. The results are based on $429~\mathrm{fb}^{-1}$ of data containing $471\times10^6\, B\overline{B}$ pairs collected at the $Υ{(4S)}$ resonance with the BaBar detector at the SLAC National Accelerator Laboratory.
description: 15 pages, 4 figures, published version
Additional file 1: of A single-cell transcriptomic atlas of the developing chicken limb
Creators: name: Feregrino, Christian
name: Sacher, Fabio
name: Parnas, Oren
name: Tschopp, Patrick
Publisher: name: Figshare
Year: 2019
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Computational Biology

description: Figure S1. Sample compositions and data statistics. (a) Cellular composition of the samples and datasets, color code corresponds to Fig. 2a-c. (b) UMI count distributions across the samples. (c) Gene count distributions across the samples. Figure S2. Expression patterns of marker genes. Related to Fig. 1. Normalized expression patterns of selected genes to identify the different cell populations in our broad clustering, plotted on the tSNEs from sample (a) HH25, (b) HH29 and (c) HH31. Figure S3. Co-expression modules expression patterns. Related to Fig. 3. Average expression of each WGCNA co-expression module on the tSNE of sample HH29. (PDF 4613 kb)
Final Report on European Strategy
Creators: name: ARIES WP1 Members
Publisher: name: Zenodo
Year: 2021

description: Research and innovation in particle accelerator science and technology is key to the progress of strategic scientific fields where Europe holds a leadership position. Moreover, accelerators are increasingly being used in health care and industry, where the availability of new accelerator technologies can improve our life quality and generate economic growth. After several decades of European prominence, in the present critical moment for the evolution of particle accelerators the increasing pressure from Asia and new far-sighted US initiatives are putting at risk the European role in this crucial scientific and technological field. After giving an overview of its main challenges and of the present instruments to coordinate and support particle accelerator research and innovation in Europe, this report presents some conclusions from the Working Groups active within the ARIES project on how to enhance industry involvement, showing as a successful example the preparation of the new I.FAST project.
 Finally, the report presents some guidelines and a roadmap identified within ARIES towards creating a sustainable ecosystem for particle accelerator research and innovation in Europe, capable of preserving the European leading position in accelerator-based scientific fields and its related advantages for high-technology European industry and for the whole European society.
description: {"references": ["ARIES Del1.1"]}
Electronic structure of Ce2RhIn8 2D heavy Fermion system studied by angle resolved photoemission spectroscopy
Creators: name: Jiang, Rui
name: Mou, Daixiang
name: Liu, Chang
name: Zhao, Xin
name: Yao, Yongxin
name: Ryu, Hyejin
name: Petrovic, C.
name: Ho, Kai-Ming
name: Kaminski, Adam
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We use angle-resolved photoemission spectroscopy to study heavy fermion superconductor Ce2RhIn8. The Fermi surface is rather complicated and consists of several hole and electron pock- ets. We do not observe kz dispersion of Fermi sheets, which is consistent with 2D character of the electronic structure. Comparison of the ARPES data and band structure calculations points to a localized picture of f electrons. Our findings pave the way for understanding the transport and thermodynamical properties of this material.
Effect of lactation on maternal postpartum cardiac function and adiposity: a murine model
Creators: name: Saade, George R.
name: Olson, Gayle L.
name: Vincent, Kathleen L.
name: Bytautiene, Egle
name: Patrikeev, Igor
name: Poole, Aaron T.
name: Stuebe, Alison
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Lactation is associated with reduction in maternal metabolic disease and hypertension later in life; however, findings in humans may be confounded by socioeconomic factors. We sought to determine the independent contribution of lactation on cardiovascular parameters and adiposity in a murine model.
Exploring the Characteristics of Instructional Design Professional Knowledge from a Facebook Community of Practice (CoP)
Creators: name: Leung, Javier
Publisher: name: figshare
Year: 2022
Subjects: subject: 130306 Educational Technology and Computing
subject: FOS: Educational sciences
subject: 130304 Educational Administration, Management and Leadership
subject: 170103 Educational Psychology
subject: FOS: Psychology

description: Online communities of practice (CoPs) in Instructional Design play an important role in creating and transferring professional knowledge (tacit knowledge). This study examines the characteristics of professional knowledge from 4,717 anonymized users’ posts available in the Instructional Designer Facebook group from August 3rd, 2017 to September 9th, 2020. This group is the largest public group on Facebook with 17,640 members as of September 29th, 2021 (About Us CrowdTangle, n.d.). Natural language processing approaches, including n-grams, sentiment analysis, visualization of named entities, and topic modeling, were implemented to extract tacit knowledge from written forms of communication. Three topic models, including bag-of-words, TF-IDF, and sentence embeddings, showed topics related to corporate training, online training, authoring e-learning tools, resource downloads, virtual reality, mobile learning, and outsourcing e-learning development. In the visualization of relationships between named entities, this particular CoP is characterized by (1) the recognition of members’ contribution and request for feedback, (2) the use of hashtags related to e-learning development and trends, and (3) the request for career advice related to the Instructional Design profession. The study has implications for developing practitioners’ pedagogical proficiencies and establishing community knowledge management and curation practices.
Higher-order massive neutrino perturbations in large-scale structure
Creators: name: Führer, Florian
name: Wong, Yvonne Y. Y.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We develop a higher-order perturbation theory for large-scale structure formation involving a free-streaming hot or warm dark matter species. We focus on the case of mixed cold dark matter and massive neutrinos, although our approach is applicable also to a single warm dark matter species. In order to capture the suppressed growth of neutrino density perturbations on small scales, we account for the full momentum dependence of the phase space distribution using the Vlaslov equation, and derive from it a formal closed-form nonlinear equation for the neutrino density. Using a systematic perturbative expansion of this equation we compute high-order corrections to the neutrino density contrast without the explicit need to track the perturbed neutrino momentum distribution. We calculate the leading-order total matter bispectrum for several neutrino masses. Using our result as a benchmark, we test the accuracy of the fluid approximation and a linear approximation used in perturbative and N-body analyses, as well as a new hybrid approach that combines the exact linear evolution with the nonlinear structure of the fluid equations. Aiming at $\lesssim1%$ accuracy, we find that the total matter bispectrum with a low neutrino mass m=0.046 eV can be reproduced by all but the fluid approximation, while for larger neutrino masses m=0.46-0.93 eV only the hybrid approach has the desired accuracy on a large range of scales. This result serves as a cautionary note that approximate nonlinear models of neutrino clustering that reproduce the gross features of some observables may not suffice for precision calculations, nor are they guaranteed to apply to other observables. All of the approximation schemes fail to reproduce the bispectrum of the neutrino density perturbations at better than 20% accuracy across all scales, indicating that an exact treatment of nonlinear neutrino perturbations is necessary.
description: v1: 42 pages, 6 figures v2: 44 pages, 8 figures, minor modifications, version accepted by JCAP
Genetic epidemiology of pelvic organ prolapse: a systematic review
Creators: name: Jerome, Rebecca N.
name: Ward, Renée M.
name: Giri, Ayush
name: Wu, Jennifer M.
name: Velez Edwards, Digna R.
name: Edwards, Todd
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Given current evidence supporting a genetic predisposition for pelvic organ prolapse (POP), we conducted a systematic review of published literature on the genetic epidemiology of POP. Inclusion criteria were linkage studies, candidate gene association and genome-wide association studies (GWAS) in adult women published in English and indexed in PubMed through December 2012, with no limit on date of publication. Methodology adhered to the PRISMA guidelines. Data were systematically extracted by two reviewers and graded by the Venice criteria for studies of genetic associations. A meta-analysis was performed on all single nucleotide polymorphisms (SNPs) evaluated by two or more studies with similar methodology. The meta-analysis suggests that collagen type 3 alpha 1 (COL3A1) rs1800255 genotype AA is associated with POP, OR 4.79 (95% CI 1.91 to 11.98, p= 0.001) compared to the reference genotype GG in populations of Asian and Dutch women. There was little evidence of heterogeneity for rs1800255 (p-value for heterogeneity= 0.94; proportion of variance due to heterogeneity, I2= 0.00%). There was insufficient evidence to determine whether other SNPs evaluated by two or more papers were associated with POP. An association with POP was seen in individual studies for estrogen receptor alpha (ER-α) rs2228480 GA, COL3A1 exon 31, chromosome 9q21 (HLOD score 3.41) as well as six SNPs identified by a GWAS. Overall, individual studies were of small sample size and often of poor quality. Future studies would benefit from more rigorous study design as outlined in the Venice recommendations.
Inadequate weight gain in overweight and obese pregnant women: what is the effect on fetal growth?
Creators: name: Wapner, Ronald J.
name: Landon, Mark B.
name: Mele, Lisa
name: Casey, Brian
name: Thorp, John M.
name: Rouse, Dwight J.
name: Catalano, Patrick M.
name: Saade, George
name: Varner, Michael W.
name: Sorokin, Yoram
name: Reddy, Uma M.
name: Peaceman, Alan M.
name: Tolosa, Jorge E.
name: Ramin, Susan M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: To evaluate inadequate gestational weight gain and fetal growth among overweight and obese women (O/O).