cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Cyclorhipidion bodoanum
Creators: name: Mandelshtam, Mikhail Yu.
name: Sergeev, Maksim E.
name: Korznikov, Kirill A.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Cyclorhipidion
Cyclorhipidion bodoanum

description: Cyclorhipidion bodoanum (Reitter, 1913)
МатериаΛ:. 4 экз.: 22.05.2022; 1 экз.: 28.05.2022
description: Published as part of Mandelshtam, Mikhail Yu., Sergeev, Maksim E. & Korznikov, Kirill A., 2023, Bark and ambrosia beetles (Coleoptera: Curculionidae: Scolytinae) from Botanical Garden-Institute of FEB RAS, Vladivostok, pp. 15-21 in Amurian Zoological Journal XV (1) on page 17, DOI: 10.33910/2686-9519-2023-15-1-15-21, http://zenodo.org/record/11089032
The Role of Estrogen Receptor in Endocrine Resistance
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The estrogen receptor (ER) is a key regulator of proliferation and survival in breast cancer cells. Anti-estrogens that block ER activity can effectively inhibit tumor growth. Aromatase inhibitors are also effective inhibitors of tumor growth, but they function differently by blocking the synthesis of estrogen. Both anti-estrogens and aromatase inhibitors show significant survival benefits for breast cancer patients, however, most patients would eventually develop resistance to these drugs. Results from our lab shows that ER still plays a critical role in the resistant cells, but the mechanism is not yet completely understood. Characterization of the changes in ER signaling will confer a better understanding of how resistance arises.

 The genome-wide profiling of ER binding sites in hormone responsive cells has been published, but this approach has not been used to study endocrine resistant cells. We hypothesize that the ER binding site profile in resistant cells is different from that in the hormone responsive cells. We will identify these differences in ER binding which will reveal the changes in ER signaling that are important for the resistant phenotype.

 To compare genome-wide profiles of ER binding sites in the hormone-responsive and resistant lines, we will characterize the ER binding profiles in breast cancer cell lines show resistance to: (1) estrogen deprivation, or (2) tamoxifen, letrozole, anastrozole, or exemestane treatment. Next, we will identify and characterize the functional significance of ER signaling changes in the hormone-responsive and resistant cell lines. The binding site profiles in combination with gene expression array data previously generated in our lab will provide further insights into the role of ER in endocrine resistance. Our methods include chromatin immunoprecipitation (ChIP) followed by massively parallel Illumina instrument-based DNA sequencing (ChIP-seq). Bioinformatics analyses of the binding site locations and organizations will unravel differences in ER binding properties and co-regulator involvement among different types of resistant lines. Correlation of the ChIP-seq data with gene expression array data will allow us to explain the functional significance of the binding events.

 The detailed elucidation of ER functions in the drug-resistant cells is a key step to understanding the mechanism of endocrine resistance, which is crucial for the design of novel strategies to overcome this widespread problem.
Mecometopus wappesi Santos-Silva & Galileo 2016
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Mecometopus
Mecometopus wappesi

description: 4. Mecometopus wappesi Santos-Silva & Galileo, 2016: 138, figs. 10–13 Holotype, male
Type locality. Brazil, Amazonas: 60 km N Manaus (Fazenda Esteio, ZF –3, km 23), 06.XII.1984, B.C. Klein
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 348, DOI: 10.5281/zenodo.250291
Hylesinus cholodkovskyi Berger 1917
Creators: name: Mandelshtam, Mikhail Yu.
name: Sergeev, Maksim E.
name: Korznikov, Kirill A.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Hylesinus
Hylesinus cholodkovskyi

description: Hylesinus cholodkovskyi Berger, 1917
МатериаΛ: 1 экз.: 29.05.2022.
description: Published as part of Mandelshtam, Mikhail Yu., Sergeev, Maksim E. & Korznikov, Kirill A., 2023, Bark and ambrosia beetles (Coleoptera: Curculionidae: Scolytinae) from Botanical Garden-Institute of FEB RAS, Vladivostok, pp. 15-21 in Amurian Zoological Journal XV (1) on page 17, DOI: 10.33910/2686-9519-2023-15-1-15-21, http://zenodo.org/record/11089032
The development of complex meaning
Creators: name: Isacoff, Nora M.
Publisher: name: No Publisher Supplied
Year: 2014

description: This dissertation explores the development of words and categories with the intention of better understanding the organization of the lexicon. Study I investigates lexical organization, lexical access, and categorization in adults. In particular, I contrast the way adults access lexical items with the way they explicitly categorize these items. By testing speakers of two different languages—English and Mandarin—I also explore which aspects of lexical organization are universal and which are linguistically relative. Study II investigates the nature of lexical representation, access, and categorization in two- through nine-year-old typically-developing children. Additionally, I investigate the way developments in categorization do and do not coincide with development of the ability to articulate these categories, with the acquisition of relevant declarative knowledge, and with developments in other cognitive abilities. The results of the first two studies suggest that lexical organization and access are qualitatively different in young children than in adults. Study III investigates the nature of the lexicon and categories in children with autism. I find that although autistic children have many cognitive deficits, they seem to follow typical patterns of category development. Together, these studies improve our understanding of the nature and development of lexical organization, lexical access, and categorization.
Olexandrella rafaeli Galileo & Martins 2011
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Olexandrella
Olexandrella rafaeli

description: 5. Olexandrella rafaeli Galileo & Martins, 2011c: 577, fig. 2 Holotype, female
Type locality. Brazil, Rondônia: Vilhena, (12°65'55"S, 60°22'21"W), 25.IV.2004, José Albertino Rafael & F.F. Xavier Filho
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 348, DOI: 10.5281/zenodo.250291
Non-contiguous spectrum access and small cell network design
Creators: name: Islam, Muhammad Nazmul
Publisher: name: No Publisher Supplied
Year: 2014

description: The explosive demand for high data rate wireless services cannot be  sustained through improvements in PHY layer technologies alone.  Opportunistic use of additional bandwidth through dynamic spectrum access  and densification of wireless networks are necessary to meet this  increasing demand, and this dissertation covers both these aspects.    The first part of the thesis focuses on a cooperative spectrum access  scenario where nodes exchange non-contiguous spectrum chunks as incentives  for cooperative forwarding. An autonomous network is considered where each  node gets an initial amount of bandwidth, and uses this bandwidth as a  flexible incentive for two hop relaying. This dissertation proposes an  incentivized forwarding based resource allocation algorithm which  maximizes the global utility of the network while preserving the initial  utility of each cooperative node.  The second part of the thesis studies  power optimal non-contiguous spectrum access. Non-Contiguous Orthogonal  Frequency Division Multiple Access (NC-OFDMA), a popular technique in  software defined radio research, accesses non-contiguous spectrum chunks  by nulling intermediate spectrum. However, nulling subcarriers increases  the sampling rate (spectrum span) which, in turn, increases the power  consumption of radio front ends. This dissertation characterizes this  trade-off from a cross-layer perspective, specifically by showing how the  slope of ADC/DAC's power consumption versus sampling rate curve influences  scheduling decisions in a multi-hop network.    The final part of the thesis focuses on two aspects of small cell network  design: (i) a prototype wireless channel measurement system that allows network  operators to measure path loss and multipath fading characteristics  between multiple candidate small cell locations and their potential users;  and (ii) joint cost optimal aggregator node placement, power allocation,  channel scheduling and routing for wireless backhaul network of small  cells.
Beraba cauera Galileo & Martins, 1999 in Martins 1999
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Beraba
Beraba cauera

description: 6. Beraba cauera Galileo & Martins, 1999 in Martins, 1999: 194, fig. 121 (Figure 11) Holotype, male
Type locality. Brazil, Amazonas: Manaus (Reserva Ducke, 26 km NE), 27.V.1955, J.G.C. Hurtado
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 349, DOI: 10.5281/zenodo.250291
Supplementary materials for the Journal of the European Mosquite Control Association: Total microbiome of an African filarial and arbovirus vector, Culex quinquefasciatus: insights into composition and prevalence of human pathogenic microbes
Creators: name: Munjita, S.M.
name: Abu, Y.E.
name: Mubemba, B.
Publisher: name: Brill Online
Year: 2025
Subjects: classificationCode: 320704
subject: Medical parasitology
classificationCode: 300909
subject: Veterinary parasitology
classificationCode: 310399
subject: Ecology not elsewhere classified

description: Culex quinquefasciatus mosquitoes are important vectors for zoonotic pathogens like West Nile virus, dengue fever virus, and Rift Valley fever virus. Despite their role in pathogen transmission, comprehensive microbiome studies of these mosquitoes in Africa are limited, with most research elsewhere focusing on their midgut microbiome. This study addresses this gap by analysing the total microbiome of African Cx. quinquefasciatus from Zambia using metagenomic next-generation sequencing (mNGS). The study generated 71,817 and 29,908 reads specific to Cx. quinquefasciatus and microbes, respectively, identifying 146 distinct microbes. Bacteria were the most prevalent, accounting for 85.6% (125/146) of all microbes, followed by viruses (8.2%, 12/146), fungi (4.8%, 7/146), and other eukaryotic organisms (1.4%, 2/146). Frequently detected genera included Rickettsia sp., Wolbachia sp., Erwinia sp., Enterococcus sp., Pantoea sp., and Providencia sp. Providencia rettgeri, Wolbachia endosymbiont of Cx. quinquefasciatus, and Rickettsia endosymbiont of Bemisia tabaci were among the most abundant species. Notably, about 7.4% of the identified microbes are known human pathogens. This study provides an overview of the microbiome of Cx. quinquefasciatus, highlighting symbiotic, commensal, and pathogenic microbes, some of which could be useful for microbial manipulation strategies to control mosquitoes and mosquito-borne pathogens.
Hylesinus eos Spessivtsev 1919
Creators: name: Mandelshtam, Mikhail Yu.
name: Sergeev, Maksim E.
name: Korznikov, Kirill A.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Hylesinus
Hylesinus eos

description: Hylesinus eos Spessivtsev, 1919
МатериаΛ: 16 экз.: 20.08.2000, поΑ корой ветроваΛьного ясеня Fraxinus sp., МЮМ; 1 экз.: 13– 28.07.2021; 2 экз.: 11.05.2022; 1 экз.: 17.05.2022.
description: Published as part of Mandelshtam, Mikhail Yu., Sergeev, Maksim E. & Korznikov, Kirill A., 2023, Bark and ambrosia beetles (Coleoptera: Curculionidae: Scolytinae) from Botanical Garden-Institute of FEB RAS, Vladivostok, pp. 15-21 in Amurian Zoological Journal XV (1) on page 17, DOI: 10.33910/2686-9519-2023-15-1-15-21, http://zenodo.org/record/11089032
Mechanisms of HSP90 inhibitor action in Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Aromatase is the enzyme that produces estrogen, the key hormone that is most associated with breast cancer. Estrogen activity results in abnormal, uncontrollable growth in cancer cells. Approximately 70% of breast cancers are estrogen-dependent. Current therapies include Tamoxifen (Tam) and aromatase inhibitors (AI), which prevent the action of estrogen and production of estrogen, respectively. These therapies are often initially effective in the clinic, but after a few years of use, breast cancer cells can develop resistance and the disease recurs. HSP90 inhibitors such as 17-DMAG, are new therapies that were developed and have already been shown to treat various types of cancers, including breast cancer. HSP90 (heat shock protein 90) is a molecular chaperone (involved in correct protein folding) and is one of the most abundant proteins in cells. In tumor cells HSP90 can act as a "buffer" for mutated proteins as a result of inactivated DNA damage repair pathways. In addition, studies on HSP90 inhibitors, such as the 17-AAG and 17-DMAG geldanamycin derivatives, have demonstrated these agents to be effective in inhibiting the proliferation of various types of cancers through the induction of apoptosis and arrest of the cell cycle. However, the detailed mechanism of how they act is still unclear.

 Our objectives are to:

 -Compare the efficacy of 17-DMAG on AI- and Tam-resistant cells.

 -Determine the mechanism of 17-DMAG mediated inhibition of cell proliferation through known cell cycle and apoptosis pathways.

 -Identify tyrosine phosphorylated proteins involved in 17-DMAG mediated inhibition of breast cancer cell proliferation and characterize the action of HSP90 involving these proteins.

 For these studies we will, first, perform proliferation assays using various anti-estrogen (Tam) and AI-resistant cell lines treated with 17-DMAG. Next, we will analyze the cell cycle and apoptosis mechanisms through FACS (cell sorting) analysis, gene and protein expression studies, and TUNEL assays (apoptosis). Finally, we plan to use mass spectrometry analysis and Western blots to study the gene and protein expression regulation in AI- and Tam-resistant cells treated with 17-DMAG.

 Elucidating the mechanism of how 17-DMAG can inhibit the proliferation of drug-resistant breast cancers will be beneficial for the development of the next generation of therapies to target endocrine-resistant breast cancer.
Hypselodoris carnea
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Hypselodoris
Hypselodoris carnea

description: Hypselodoris carnea (Bergh, 1889)
(Figures 7 I –J)
Material examined. Twelve specimens. MB28-004477, ZWH, 0 8 Feb. 2012, 18 m, 25mm, collected by S. Bruck; MB28-004478, ZWH, 0 8 Feb. 2012, 16 m, 26mm, collected by S. Bruck; MB28-004487, ZGWN, 23 Feb. 2012, 25 m, 22mm, collected by S. Bruck; MB28-004516, ZDD, 23 Feb. 2012, 1 m, 31mm; MHN-YT358, ZSC, 14 May 2012, 22, 10mm; MB28-004570, ZSC, 0 8 Jun. 2012, 22 m, 15mm; ZMBN117029, ZWH, 13 Jun. 2012, 17 m, 8mm; MHN-YT471, ZWH, 17 Jun. 2012, 18 m, 32mm; ZMBN117032, ZAR, 22 Aug. 2012, 30 m, 32mm, collected by J. Bergman; ZMBN117039, ZJS, 13 Jun. 2013, 8 m, 10mm; MB28-004688, ZM, 13 Jun. 2013, 8 m, 16mm; MB28- 0 0 4865, POB, 12 May 2014, 15m, 23mm.
Habitats. Subtropical tidal reef and rocky reef.
Occurrences. Ponta do Ouro and Zavora.
Geographic distribution. Indian Ocean. Arabian Sea (Debelius 1996), Yemen, Oman, Réunion Island (Gosliner et al. 2008), Mauritius, South Africa (Gosliner 1987) and Mozambique.
Remarks. This species shows a gradual variation in colour from light-creamy with several red spots to darkbrown with fewer spots (Figs. 7 I –J). H. carnea is externally similar to H. capensis (Barnard 1927), but H. capensis seems to be restricted to the temperate waters of South Africa (Gosliner & Johnson 1999).
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on page 33, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Size and shape-based separation using deterministic lateral displacement microfludic systems
Creators: name: Jiang, Mingliang
Publisher: name: No Publisher Supplied
Year: 2014

description: Continuous separation of particles of different sizes and shapes is important in both clinical diagnostics and industrial applications and a number of methods have been developed for such separations. In microfluidic systems, deterministic lateral displacement has proved its great potential in achieving the goal of high throughput and efficient separation. Although it was originally based on transporting the suspension in a convective flow, particles can be also driven with external force fields, thus force-driven DLD (f-DLD) devices were demonstrated. This thesis demonstrates the separation of suspended particles by shape and size using scaled-up macroscopic f-DLD devices, using gravity force and a centrifuge, respectively. In the first set of experiments and for the first time, we demonstrate the potential of gravity-driven DLD devices for the separation of particles of different shapes. Our results show that each type of particle moves in different directions within the array of obstacles in DLD systems, depending on the forcing direction. Interestingly, we show that the migration of the particles can be predicted by the diameter of the inscribed sphere, independent of shape. In the second set of experiments and also for the first time, we combined DLD devices with centrifugal force as the driving field. We show that spherical particles of different sizes are driven to different outlets. We show that at some specific angles this setup provides high separation resolution, but the resolution decreases as the concentration of particles increases.
Hylurgops spessiwzeffi Eggers 1914
Creators: name: Mandelshtam, Mikhail Yu.
name: Sergeev, Maksim E.
name: Korznikov, Kirill A.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Hylurgops
Hylurgops spessiwzeffi

description: Hylurgops spessiwzeffi Eggers, 1914
МатериаΛ: 1 экз.: 2.06.2021.
description: Published as part of Mandelshtam, Mikhail Yu., Sergeev, Maksim E. & Korznikov, Kirill A., 2023, Bark and ambrosia beetles (Coleoptera: Curculionidae: Scolytinae) from Botanical Garden-Institute of FEB RAS, Vladivostok, pp. 15-21 in Amurian Zoological Journal XV (1) on page 18, DOI: 10.33910/2686-9519-2023-15-1-15-21, http://zenodo.org/record/11089032
Medicare Part D:Implementation, Impact and HIV/AIDS Policy
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: For Californians living with HIV/AIDS, the implementation of the Medicare prescription drug plan in 2006 is the biggest change in access to care and treatment, since the advent of the state’s AIDS Drug Assistance Program (ADAP) in 1987. Known as Part D, the program updates Medicare coverage for millions of senior citizens and people with disabilities, including HIV/AIDS, with coverage for prescription drugs. For people living with HIV/AIDS (PLWHA) whose survival depends on drug treatment, little is more important. Because Part D intersects with and may supplant existing program like Medi-Cal and ADAP, whether Part D results in an expansion or a contraction of coverage for PLWHA remains to be seen. This is the question that AIDS Project Los Angeles (APLA) and California State University at Dominguez Hills (CSUDH) will try to answer. Over the next two years, collaborating research teams will interview and survey 250 APLA clients about their experience with Part D. All clients will be dually eligible for Medicare and Medi-Cal. As such, they will be disabled and low-income. The collaborators will ask about perceived as well as actual problems with Part D -- from the initial enrollment period, to whether drugs are now cost them more than before, to whether Part D has affected their access and adherence to care and treatment. Once the data is compiled, the research team will analyze and interpret the information. The collaborators will also conduct interviews with health policy experts, HIV/AIDS service providers (benefits counselors and case managers), pharmacy and clinic staff, and state and federal health department administrators likely to be familiar with Part D and its impact on PLWHA. Finally, the collaborators will convene some of these individuals, along with participating PLWHA and the policy advisors, for a one day think tank to craft policy recommendations for both state and federal programs. These recommendations will then be published and circulated in a policy report on Medicare Part D.
Anelaphus robi Hrabovsky 1987
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Anelaphus
Anelaphus robi

description: 7. Anelaphus robi Hrabovsky, 1987: 135, fig. 1 (Figure 12) Holotype, male
Type locality. Brazil, Amazonas: AM 0 10, km 246
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 349, DOI: 10.5281/zenodo.250291
Genetic and environmental modulation of necrosis and health span in Caenorhabditis elegans
Creators: name: Kamat, Shaunak
Publisher: name: No Publisher Supplied
Year: 2014

description: Living systems rely on tightly regulated gene expression networks in order to maintain a stable internal milieu, a process known as homeostasis, and to interact with their environment. The study of regulatory networks involved in key processes such as energy metabolism and cellular responses to hostile environmental conditions has immense therapeutic potential and is the focus of a large and growing body of research. This dissertation describes two processes – neuronal necrosis, and the metabolic effects of the phytoecdysteroid 20-hydroxyecdysone in the invertebrate model system C. elegans, with a focus on the underlying molecular mechanisms and their potential therapeutic value.     The first part of this dissertation deals with the cellular response to necrosis, a catastrophic event caused by extreme departure from homeostatic conditions due to exposure to toxic chemicals, extreme temperature or mechanical trauma. Using genetically encoded hyperactive DEG/ENaC ion channels as inducers of necrosis, I describe the role of ER chaperone NRA-2 in the modulation of necrosis caused by calcium excitotoxicity and suggest a broader role for ER chaperones in the regulation of channel expression, with potential therapeutic value in the treatment of disease pathology caused by malformed DEG/ENaC channels. The second part of this dissertation deals with the effects of the plant-derived steroid hormone 20-hydroxyecdysone (20HE) that extends C. elegans health span and modulates energy metabolism. I describe the effects of this compound on conserved metabolic pathways and suggest a potential mechanism of action. This study highlights the conservation of gene networks governing nutrient metabolism and the importance of C. elegans as a model system in identifying therapeutic targets for the treatment of metabolic syndrome.     In sum, the dissertation describes two unrelated processes in C. elegans with the common theme being a conserved genetically encoded regulatory network and its interaction with a specific environmental cue.
Additional file 5: Figure S6. of Chloroplast PetD protein: evidence for SRP/Alb3-dependent insertion into the thylakoid membrane
Creators: name: Jarosław Króliczewski
name: Rafał Bartoszewski
name: Bożena Króliczewska
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences

description: Analyses of thylakoid membrane fractions and stroma after insertion of PetB or PsbW protein by spontaneous pathway. (PDF 121 kb)
Hylurgops transbaicalicus Eggers 1941
Creators: name: Mandelshtam, Mikhail Yu.
name: Sergeev, Maksim E.
name: Korznikov, Kirill A.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Hylurgops
Hylurgops transbaicalicus

description: Hylurgops transbaicalicus Eggers, 1941
МатериаΛ: 2 экз.: 13.07.2021, ветроваΛьный кеΑр, МЕС.
description: Published as part of Mandelshtam, Mikhail Yu., Sergeev, Maksim E. & Korznikov, Kirill A., 2023, Bark and ambrosia beetles (Coleoptera: Curculionidae: Scolytinae) from Botanical Garden-Institute of FEB RAS, Vladivostok, pp. 15-21 in Amurian Zoological Journal XV (1) on page 18, DOI: 10.33910/2686-9519-2023-15-1-15-21, http://zenodo.org/record/11089032
Protein Markers in Nipple Aspirates for Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: This study is aimed at developing a diagnostic tool for early detection of breast cancer where conventional technology has not been very effective. Screening mammography has been shown to save lives by early detection of cancer masses. However, it has not been very effective in younger women and others who have dense breasts. An adjunct diagnostic tool for better detection is urgently needed. We hypothesized that unique protein biomarkers of breast cancer exist locally in mammal secretions. When secreted into nipple aspirates, these proteins can be used to distinguish breast cancer from its normal counterpart. Studies on nipple aspirates in the past have shown that the evidence of abnormal cells in the fluid correlates positively with the risk of breast cancer. While nipple aspirates can be elicited in a majority of the women, particularly in the young, the amount of fluid that is available for screening is minute. As a result, informative cytology may not be feasible for clinical decision making.

 Conventional biochemical/immunological assays have not been successful in screening a large number of known protein molecules. Recently, the Surface-Enhanced Laser Desorption/Ionization (SELDI) mass spectrometry with protein chip is shown to be able to screen proteins over a wide range of molecular weights. We propose to employ SELDI assay with the protein technology to compare the protein profiled in the nipple aspirates of cancerous and normal breasts. It is our goal that the proposed study will help identify candidate biomarkers of breast cancer. The expected discovery will be conducive to further development of diagnostic tools for early detection of breast cancer.
Mephritus apicepullus Galileo& Martins 2011
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Mephritus
Mephritus apicepullus

description: 8. Mephritus apicepullus Galileo& Martins, 2011c: 578, fig. 4 Holotype, male
Type locality. Brazil, Amazonas: Fonte Boa (02°32'27"S, 66°04'08"W), 27.IX.2006, F.F. Xavier Filho
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 349, DOI: 10.5281/zenodo.250291
Heteroborips seriatus
Creators: name: Mandelshtam, Mikhail Yu.
name: Sergeev, Maksim E.
name: Korznikov, Kirill A.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Heteroborips
Heteroborips seriatus

description: Heteroborips seriatus (Blandford, 1894)
МатериаΛ: 3 экз.: 22.05.2022.
description: Published as part of Mandelshtam, Mikhail Yu., Sergeev, Maksim E. & Korznikov, Kirill A., 2023, Bark and ambrosia beetles (Coleoptera: Curculionidae: Scolytinae) from Botanical Garden-Institute of FEB RAS, Vladivostok, pp. 15-21 in Amurian Zoological Journal XV (1) on page 17, DOI: 10.33910/2686-9519-2023-15-1-15-21, http://zenodo.org/record/11089032
Internal and forced variability of the Equatorial Pacific on millenial and centennial time scales
Creators: name: Kalansky, Julie
Publisher: name: No Publisher Supplied
Year: 2014

description: Although the equatorial Pacific (EP) is important to climate on interannual and decadal time scales relatively little is known about its variability and its role in the climate system on longer time scales. The main objectives of this thesis are to examine the centennial and millennial temperature variability of different regions in the EP, to determine the cause of this variability and to understand the impact of this variability on the climate system. The primary temperature proxy used is Mg/Ca from Neogloboquadrina dutertrei, a planktonic foraminifera that lives between &5-150 m. Other proxies include alkenone Uk’3& ratios to reconstruct sea surface temperature (SST) and Mg/Ca from benthic foraminifera to reconstruct bottom water temperature. Additionally, δ18O is used as a temperature and salinity proxy and δ13C is used as a water mass tracer. Reconstructions are from the eastern equatorial Pacific (EEP) in chapter 2 and 3, and the reconstruction in chapter 4 is from the Indonesian Throughflow (ITF). The second chapter focuses on the entire Holocene and the third and fourth chapters focus on the Common Era.  The primary results from both locations and all timescales suggest the millennial and centennial dynamics are distinct from interannual and decadal dynamics. Prior to 8  ii  kyr B.P. EEP thermostad temperatures are warm which is arguably caused by the Southern Westerly Winds being located farther South. After 8 kyr, thermostad temperatures show millennial and centennial variability, implying that in absence of a strong climate signal from the southern high latitudes, centennial variability in the EEP thermodstad is dominated by intrinsic variability. Intrinsic variability also affects SSTs in the EEP for the last 2,500 as SSTs are not responding solar variability or Northern Hemisphere temperatures. In the ITF, thermocline temperatures vary due to modulations in the regional monsoon. Neither data from the EEP nor ITF indicate that ENSO modulations are influencing centennial variability. The results from both regions caution against using ENSO to explain centennial variability and suggest the role of the EP in the climate system on centennial and longer time scales is more moderate than on interannual to decadal time scales.
Hylesinus laticollis Blandford 1894
Creators: name: Mandelshtam, Mikhail Yu.
name: Sergeev, Maksim E.
name: Korznikov, Kirill A.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Hylesinus
Hylesinus laticollis

description: Hylesinus laticollis Blandford, 1894
МатериаΛ: 12 экз.: 20.08.2000, поΑ корой ветроваΛьного ясеня Fraxinus sp., МЮМ; 1 экз.: 29.05.2022.
description: Published as part of Mandelshtam, Mikhail Yu., Sergeev, Maksim E. & Korznikov, Kirill A., 2023, Bark and ambrosia beetles (Coleoptera: Curculionidae: Scolytinae) from Botanical Garden-Institute of FEB RAS, Vladivostok, pp. 15-21 in Amurian Zoological Journal XV (1) on page 18, DOI: 10.33910/2686-9519-2023-15-1-15-21, http://zenodo.org/record/11089032
Additional file 6: Table S1. of Chloroplast PetD protein: evidence for SRP/Alb3-dependent insertion into the thylakoid membrane
Creators: name: Jarosław Króliczewski
name: Rafał Bartoszewski
name: Bożena Króliczewska
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Developmental Biology
subject: Marine Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences

description: Analysis of proteins co-immunoprecipitated with PetD after in vitro translation followed by posttranslational insertion into thylakoid membrane. (PDF 119 kb)
Hypselodoris emma Rudman 1977
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Hypselodoris
Hypselodoris emma

description: Hypselodoris emma Rudman, 1977
(Figure 7 K)
Material examined. Three specimens. MB28-004548, ZRP, 20 May 2012, 1m, 30mm; MHN-YT747, ZWH, 0 8 Mar. 2013, 16m, 28mm; MB28-004989, ZRP, 0 5 May 2015, 0.3m, 24mm.
Habitats. Subtropical tidal reefs and rocky reefs.
Occurrences. Zavora.
Geographic distribution. Indo-west Pacific. Japan, Papua New Guinea, Australia, Philippines (Gosliner et al. 2008), Indonesia, Maldives, Vietnam (Debelius 1996), India (Remakrishna et al. 2010), Comoros Islands, Madagascar (Gosliner et al. 2008), Kenya Tanzania (Rudman 1977) and Mozambique.
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on page 33, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Mephritus estoni Galileo & Martins 2011
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Mephritus
Mephritus estoni

description: 9. Mephritus estoni Galileo & Martins, 2011c: 580, fig. 6 Holotype, male
Type locality. Brazil, Amazonas: Manaus (Estrada ZF 2), 1.X.2005, José Albertino Rafael, F.F. Xavier Filho, R. Machado, A.A. Agudelo & Y.K. Dantas
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 349, DOI: 10.5281/zenodo.250291
НОВЕЙШИЕ ТЕХНОЛОГИИ В СФЕРЕ ЭКОНОМИКИ И БИЗНЕСА
Creators: name: Саминжонов, Нуриллохон
Publisher: name: Zenodo
Year: 2025

description: В данной статье мы рассмотрим новейшие технологии, которые трансформируют экономику и бизнес, и их влияние на различные аспекты, от производства до маркетинга. Функционирование экономической сферы и последовательное развитие отрасли происходят непрерывно, создавая необходимость глубокого изучения доступных целей, практических методов работы, возможностей улучшить существующие процессы и увеличить общую эффективность экономики страны.
title: I cardini della modernità penale dai codici Rocco alle stagioni dell’Italia repubblicana
Creators: name: Garlati, Loredana
name: N. Miletti, Marco
name: Donini, Massimo
name: Orlandi, Renzo
Publisher: name: Roma Tre University
publisherIdentifier: https://ror.org/05vf0dg29
publisherIdentifierScheme: ROR
Year: 2024

description:

Il volume raccoglie i risultati di una riflessione interdisciplinare intorno al diritto penale e processuale penale. Penalisti e processual-penalisti si sono confrontati con storici del diritto e del processo penale per analizzare i risultati cui sono giunte le discipline penalistiche negli ultimi centocinquant’anni, per discutere dei problemi vecchi e nuovi della giustizia penale e per valutarne le attuali e future prospettive. Le pagine qui contenute confermano ancora una volta quanto la materia penalistica sia ineludibilmente e profondamente radicata nella dimensione sociale e in quella storica. Sono qui riprese le grandi questioni della penalistica come la ‘funzione’ della pena e la sua ‘certezza’ o i modelli processuali da preferire per meglio rispondere alle differenti esigenze di accertare le responsabilità, garantire gli imputati, ma anche – se non soprattutto – assicurare l’ordine pubblico e la tranquillità dei cittadini. Per rispondere a tali questioni lo studio attento dei problemi deve essere accompagnato dalla volontà di immaginare e proporre delle soluzioni che siano socialmente praticabili e sostenibili.
Automatic quantification of cell viability in hippocampal organotypic cultures
Creators: name: Kannan, Aparna
Publisher: name: No Publisher Supplied
Year: 2014

description: Traumatic Brain Injury (TBI) is a leading cause of disability with many different types of forces. Because the brain is made of up interconnected nerve cells, injury from one area of brain can easily spread throughout the rest of the brain. In order to study this effect in this paper, we use hippocampal organotypic cell cultures. To analyze how secondary and further injury is spread in the brain due to TBI, specific regions of interest are outlined using bright-field microscopy images and analyzed for cell death through fluorescent images. Because of the bias in segmenting these specific regions, and the darkening of bright-field images from necrosis, there is a need for the development of an automatic cell viability analysis method. We first create silhouette masks identifying the area of the hippocampus within the bright-field images. Then, we align these masks of these images between two time points – one before experimentation and another 24 hours after lab experimentation - using Mattes Mutual Information registration to help analyze corresponding regions between time points. We also use relative intensity gradients and contrast enhancement to help isolate the specific regions of interest within the hippocampus, and then aligned the regions of interest between time points using the transformation discovered through the registration process. Finally, we look within these extracted regions for cell viability in fluorescent images taken after experimentation and calculate the ratio between the area of the fluorescent region extracted and the area of the segmented region. Comparing the results from this method with manual segmentation by experienced users, we discover an average of 12% error in segmentation and 2% error in registration. The overall method took an average of & minutes per image, which compared to the time it takes complete manually, allows users to conserve time and prevent user-to-user bias in segmentation.
Taming the jabberwocky
Creators: name: Kharkwal, Gaurav
Publisher: name: No Publisher Supplied
Year: 2014

description: Previous research suggests people are remarkably good at processing sentences that contain novel words.  For example, although we do not know what cratomize means, we know that the sentence The man cratomized the boy is grammatical (unlike The man cratomize the boy), and we can answer questions about it (e.g., who did the man cratomize?).  This dissertation investigates the role of syntactic and morphological information in human sentence processing using relative clause sentences containing nonsense words, such as The actor who cratomized the critic impressed the director and The actor who the cratomer humiliated impressed the director.      Experiments 1 and 2 reveal that human sentence processing is an automatic reflex which is unaffected by task requirements or presence of novel words.  Subsequent experiments further examine processing of such sentences. Experiment 3 reveals that the impact of syntactic context is so great that, for certain syntactic positions, processing novel words bears no additional cost.  Experiments 4-6 investigate how syntactic and morphological information interact.  These experiments reveal that syntactic information plays a dominant role with morphology playing a very minor role, with incongruence between syntactic and morphological information always being resolved in favor of syntax.      In addition to these behavioral studies, we propose two extensions of existing computational models of sentence processing that enable the models to process sentences with novel words.  Our evaluations suggest that the integration of sentence processing models with models of word recognition is a promising future avenue of research. Furthermore, our analyses of English corpora reveal that derivational and inflectional suffixes tend to be infrequently and unreliably used in English, which may (partially) explain why morphological information plays such a minor role in English sentence processing.    In the last section of the dissertation, we conduct cross-linguistic analyses that reveal an inverse relation between morphological and syntactic information.  Specifically, languages with freer word-order constraints tend to be morphologically richer than languages with strict syntactic constraints, such as English. This hints at a possibility that morphology might play a greater role during sentence processing in languages that have richer morphology than English.
Ips acuminatus
Creators: name: Mandelshtam, Mikhail Yu.
name: Sergeev, Maksim E.
name: Korznikov, Kirill A.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Ips
Ips acuminatus

description: Ips acuminatus (Gyllenhal, 1827)
МатериаΛ: 14 экз.: 2.06.2021; 36 экз.: 13.07.2021, ветроваΛьный кеΑр, МЕС; 18 экз.: 13– 28.07.2021; 53 экз.: 10.05.2022, массовый Λет на свежих ветроваΛах, МЕС; 3 экз.: 11.05.2022.
description: Published as part of Mandelshtam, Mikhail Yu., Sergeev, Maksim E. & Korznikov, Kirill A., 2023, Bark and ambrosia beetles (Coleoptera: Curculionidae: Scolytinae) from Botanical Garden-Institute of FEB RAS, Vladivostok, pp. 15-21 in Amurian Zoological Journal XV (1) on page 18, DOI: 10.33910/2686-9519-2023-15-1-15-21, http://zenodo.org/record/11089032
Mephritus vescus Galileo & Martins 2011
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Mephritus
Mephritus vescus

description: 10. Mephritus vescus Galileo & Martins, 2011c: 578, fig. 5
Holotype, male
Type locality. Brazil, Amazonas: Manaus (Reserva Biológica de Cuieiras, base de apoio da ZF/2 [02°35'21"S, 60°06'55"W], 24.X.2007, José Albertino Rafael, F.S.P. Godoi, R.J.P. Machado, A. Filho & R.R. Caviccioli
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 349, DOI: 10.5281/zenodo.250291
Compsibidion manauara Martins & Galileo 2012
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Compsibidion
Compsibidion manauara

description: 11. Compsibidion manauara Martins & Galileo, 2012: 206, fig. 11 Holotype, female
Type locality. Brazil, Amazonas: 60 km North of Manaus, Reserva PDBFF (Projeto Diversidade Biológica em Fragmento Florestal, Reserva 1112), 21.VIII.1984, B. Klein
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 349, DOI: 10.5281/zenodo.250291
Hylurgops interstitialis
Creators: name: Mandelshtam, Mikhail Yu.
name: Sergeev, Maksim E.
name: Korznikov, Kirill A.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Hylurgops
Hylurgops interstitialis

description: Hylurgops interstitialis (Chapuis, 1875)
МатериаΛ: 25 экз.: 2.06.2021; 1 экз.: 13.07.2021, ветроваΛьный кеΑр, МЕС; 1 экз.: 13– 28.07.2021; 10 экз.: 5.08.2021, ствоΛы ветроваΛьных кеΑров Αиаметром 30–40 см, МЕС; 3 экз.: 5.05.2022, поΑ корой ветроваΛьного кеΑра, МЕС.
description: Published as part of Mandelshtam, Mikhail Yu., Sergeev, Maksim E. & Korznikov, Kirill A., 2023, Bark and ambrosia beetles (Coleoptera: Curculionidae: Scolytinae) from Botanical Garden-Institute of FEB RAS, Vladivostok, pp. 15-21 in Amurian Zoological Journal XV (1) on page 18, DOI: 10.33910/2686-9519-2023-15-1-15-21, http://zenodo.org/record/11089032