cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Atmospheric dynamics and the variable transit of KELT-9 b
Creators: name: Cauley, P. Wilson
name: Shkolnik, Evgenya L.
name: Ilyin, Ilya
name: Strassmeier, Klauss G.
name: Redfield, Seth
name: Jensen, Adam G.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present a spectrally and temporally resolved detection of the optical Mg I triplet at 7.8$σ$ in the extended atmosphere of the ultra-hot Jupiter KELT-9 b, adding to the list of detected metal species in the hottest gas giant currently known. Constraints are placed on the density and radial extent of the excited hydrogen envelope using simultaneous observations of H$α$ and H$β$ under the assumption of a spherically symmetric atmosphere. We find that planetary rotational broadening of $v_\text{rot} = 8.2^{+0.6}_{-0.7}$ km s$^{-1}$ is necessary to reproduce the Balmer line transmission profile shapes, where the model including rotation is strongly preferred over the non-rotating model using a Bayesian information criterion comparison. The time-series of both metal line and hydrogen absorption show remarkable structure, suggesting that the atmosphere observed during this transit is dynamic rather than static. We detect a relative emission feature near the end of the transit which exhibits a P-Cygni-like shape, evidence of material moving at $\approx 50-100$ km s$^{-1}$ away from the planet. We hypothesize that the in-transit variability and subsequent P-Cygni-like profiles are due to a flaring event that caused the atmosphere to expand, resulting in unbound material being accelerated to high speeds by stellar radiation pressure. Further spectroscopic transit observations will help establish the frequency of such events.
description: Accepted to AJ on 12/06/18. 24 pages, 12 main text figures, 6 appendix figures
Additional file 6: of Autologous stem cell therapy for peripheral arterial disease: a systematic review and meta-analysis of randomized controlled trials
Creators: name: Gao, Wei
name: Chen, Dawei
name: Liu, Guanjian
name: Ran, Xingwu
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Cell Biology
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Figure S4. Funnel plot of ulcer healing rate. (DOCX 22 kb)
Final-State Interactions in e^+e^- -> t\bar{t} -> b l^+ ν\bar{b} W^- Near Top Quark Threshold
Creators: name: Peter, M.
name: Sumino, Y.
Publisher: name: arXiv
Year: 1997
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We calculate final-state interaction corrections to the energy-angular distribution of l^+ in semi-leptonic top quark decay, where the parent top quark is produced via e^+e^- -> t\bar{t} near threshold. These are the corrections due to gluon exchange between t and \bar{b} (\bar{t} and b) and between b and \bar{b}. Combining with previously known other corrections, we explicitly write down the l^+ energy-angular distribution including the full O(alpha_s)=O(beta) corrections near t\bar{t} threshold. Numerical analyses of the final-state interaction corrections are given. We find that they deform the l^+ distribution typically at the 10% level. We also find that all qualitative features of the numerical results can be understood from intuitive pictures. The mechanisms of various effects of the final-state interactions are elucidated. Finally we define an observable which is proper to the decay process of the top quark (dependent only on dΓ_{t -> b l^+ ν}/ dE_l dΩ_l of a free polarized top quark) near t\bar{t} threshold. Such a quantity will be useful in extracting the decay property of the top quark using the highly polarized top quark samples.
description: Section 6 is enlarged substantially and a paragraph is added to Section 8 correspondingly. Reference list is also improved. (27 pages including figures, LaTeX)
Spontaneous emission of phonons by coupled quantum dots
Creators: name: Brandes, Tobias
name: Kramer, Bernhard
Publisher: name: arXiv
Year: 1999
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We find an interference effect for electron-phonon interactions in coupled semiconductor quantum dots that can dominate the nonlinear transport properties even for temperatures close to zero. The intradot electron tunnel process leads to a `shake up' of the phonon system and is dominated by a double-slit-like interference effect of spontaneously emitted phonons. The effect is closely related to subradiance of photons (Dicke effect) in a laser-trapped two-ion system and explains the oscillations in the nonlinear current-voltage characteristics of coupled dots observed recently.
description: to appear in PRL
title: Muckle-Wells-Syndrom: Wenn Taube wieder hören können
Creators: name: Griesinger, Andreas
name: Hansmann, Sandra
name: Hospach, Anton
name: Samba, Samuel
name: Kümmerle-Deschner, Jasmin B.
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die Krankengeschichte des vorgestellten Falles begann bereits im Alter von 6 Monaten mit seither bestehenden ausgeprägten Hauteffloreszenzen im Sinne einer chronischen Urtikaria im Gesicht und an den Extremitäten. Mit drei Jahren traten Diarrhoe, Bauch- und Hüftgelenksschmerzen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 47. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 33. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 29. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Theory of continuum percolation I. General formalism
Creators: name: Drory, Alon
Publisher: name: arXiv
Year: 1996
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: The theoretical basis of continuum percolation has changed greatly since its beginning as little more than an analogy with lattice systems. Nevertheless, there is yet no comprehensive theory of this field. A basis for such a theory is provided here with the introduction of the Potts fluid, a system of interacting $s$-state spins which are free to move in the continuum. In the $s \to 1$ limit, the Potts magnetization, susceptibility and correlation functions are directly related to the percolation probability, the mean cluster size and the pair-connectedness, respectively. Through the Hamiltonian formulation of the Potts fluid, the standard methods of statistical mechanics can therefore be used in the continuum percolation problem.
description: 26 pages, Latex
The Master Field for QCD and $q$-Deformed Quantum Field Theory
Creators: name: Aref'eva, I. Ya.
name: Volovich, I. V.
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Quantum Algebra (math.QA)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: The master fields for the large $N$ limit of matrix models and gauge theory are constructed. The master fields satisfy to standard equations of relativistic field theory but fields are quantized according to a new rule. To define the master field we use the Yang-Feldman equation with a free field quantized in the Boltzmannian Fock space. The master field for gauge theory does not take values in a finite-dimensional Lie algebra however there is a non-Abelian gauge symmetry. For the construction of the master field it is essential to work in Minkowski space-time and to use the Wightman correlation functions. The BRST quantization of the master field for gauge theory and a loop equation are considered.
description: More comments about a new gauge theory and more references are added, 14 pages, latex
Evoplex: A platform for agent-based modeling on networks
Creators: name: Cardinot, Marcos
name: O'Riordan, Colm
name: Griffith, Josephine
name: Perc, Matjaž
Publisher: name: arXiv
Year: 2018
Subjects: subject: Multiagent Systems (cs.MA)
subject: Neural and Evolutionary Computing (cs.NE)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: Agent-based modeling and network science have been used extensively to advance our understanding of emergent collective behavior in systems that are composed of a large number of simple interacting individuals or agents. With the increasing availability of high computational power in affordable personal computers, dedicated efforts to develop multi-threaded, scalable and easy-to-use software for agent-based simulations are needed more than ever. Evoplex meets this need by providing a fast, robust and extensible platform for developing agent-based models and multi-agent systems on networks. Each agent is represented as a node and interacts with its neighbors, as defined by the network structure. Evoplex is ideal for modeling complex systems, for example in evolutionary game theory and computational social science. In Evoplex, the models are not coupled to the execution parameters or the visualization tools, and there is a user-friendly graphical interface which makes it easy for all users, ranging from newcomers to experienced, to create, analyze, replicate and reproduce the experiments.
description: 6 pages, 5 figures; accepted for publication in SoftwareX [software available at https://evoplex.org]
Additional file 7: of Autologous stem cell therapy for peripheral arterial disease: a systematic review and meta-analysis of randomized controlled trials
Creators: name: Gao, Wei
name: Chen, Dawei
name: Liu, Guanjian
name: Ran, Xingwu
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Figure S5. Funnel plot of ABI. (DOCX 21 kb)
title: Eine multizentrische, offene Studie zur Beurteilung der Sicherheit und Wirksamkeit eines elektromechanischen Injektionsgeräts zur Selbstinjektion von Certolizumab Pegol
Creators: name: Wiegratz, Susanne
name: Tatla, Daljit
name: Mountian, Irina
name: Szegvari, Boglarka
name: VanLunen, Brenda
name: Schiff, Michael
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Certolizumab Pegol (CZP) ist ein Fc-freier, PEGylierter Antikörper gegen TNF-α, zugelassen für rheumatoide Arthritis (RA), Psoriasisarthritis (PsA), Plaque-Psoriasis und axiale Spondylarthritis (axSpA). In Europa wurde ava®, ein wiederverwendbares elektromechanisches[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 47. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 33. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 29. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Weak ferromagnetism and field-induced spin reorientation in K2V3O8
Creators: name: Lumsden, M. D.
name: Sales, B. C.
name: Mandrus, D.
name: Nagler, S. E.
name: Thompson, J. R.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Magnetization and neutron diffraction measurements indicate long-range antiferromagnetic ordering below TN=4 K in the 2D, S=1/2 Heisenberg antiferromagnet K2V3O8. The ordered state exhibits ``weak ferromagnetism'' and novel, field-induced spin reorientations. These experimental observations are well described by a classical, two-spin Heisenberg model incorporating Dzyaloshinskii-Moriya interactions and an additional c-axis anisotropy. This additional anisotropy can be accounted for by inclusion of the symmetric anisotropy term recently described by Kaplan, Shekhtman, Entin-Wohlman, and Aharony. This suggests that K2V3O8 may be a very unique system where the qualitative behavior relies on the presence of this symmetric anisotropy.
description: 5 pages, 4 ps figures, REVTEX, submitted to PRL
Linear response theory for quantum Gaussian processes
Creators: name: Mehboudi, Mohammad
name: Parrondo, Juan. M. R.
name: Acin, Antonio
Publisher: name: arXiv
Year: 2019
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Fluctuation dissipation theorems connect the linear response of a physical system to a perturbation to the steady-state correlation functions. Until now, most of these theorems have been derived for finite-dimensional systems. However, many relevant physical processes are described by systems of infinite dimension in the Gaussian regime. In this work, we find a linear response theory for quantum Gaussian systems subject to time dependent Gaussian channels. In particular, we establish a fluctuation dissipation theorem for the covariance matrix that connects its linear response at any time to the steady state two-time correlations. The theorem covers non-equilibrium scenarios as it does not require the steady state to be at thermal equilibrium. We further show how our results simplify the study of Gaussian systems subject to a time dependent Lindbladian master equation. Finally, we illustrate the usage of our new scheme through some examples. Due to broad generality of the Gaussian formalism, we expect our results to find an application in many physical platforms, such as opto-mechanical systems in the presence of external noise or driven quantum heat devices.
description: Close to the published version
Higher Twist Distribution Amplitudes of Vector Mesons in QCD: Formalism and Twist Three Distributions
Creators: name: Ball, Patricia
name: Braun, V. M.
name: Koike, Y.
name: Tanaka, K.
Publisher: name: arXiv
Year: 1998
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present a systematic study of twist three light-cone distribution amplitudes of vector mesons in QCD, which is based on conformal expansion and takes into account meson and quark mass corrections. A complete set of distribution amplitudes is constructed for rho, omega, K* and phi mesons, which satisfies all (exact) equations of motion and constraints from conformal expansion. Nonperturbative input parameters are calculated from QCD sum rules, including an update of SU(3) breaking corrections in the leading twist distributions.
description: 60 pages, Latex, 3 figures; some misprints corrected and a reference added, To appear in Nucl. Phys. B
Theory of continuum percolation II. Mean field theory
Creators: name: Drory, Alon
Publisher: name: arXiv
Year: 1996
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: I use a previously introduced mapping between the continuum percolation model and the Potts fluid to derive a mean field theory of continuum percolation systems. This is done by introducing a new variational principle, the basis of which has to be taken, for now, as heuristic. The critical exponents obtained are $β= 1$, $γ= 1$ and $ν= 0.5$, which are identical with the mean field exponents of lattice percolation. The critical density in this approximation is $ρ_c = 1/\ve$ where $\ve = \int d \x \, p(\x) \{ \exp [- v(\x)/kT] - 1 \}$. $p(\x)$ is the binding probability of two particles separated by $\x$ and $v(\x)$ is their interaction potential.
description: 25 pages, Latex
Modelo de capacitación educativo-preventivo para profesores generales integrales de la secundaria básica Enrique Galarraga Rodríguez
Creators: name: Martínez Ibarra, Oriniel
Publisher: name: figshare
Year: 2021
Subjects: subject: Education
subject: 130106 Secondary Education
subject: FOS: Educational sciences

description: La presente investigación propone un modelo de capacitación educativo – preventivo que pretende contribuir al desarrollo profesional del profesor general integral de la Secundaria Básica “Enrique Galarraga Rodríguez”, enclavada en el Consejo Popular “Jesús María” del municipio La Habana Vieja. Este modelo va dirigido a estos docentes por su desempeño en condiciones socioeducativas difíciles o desfavorecedoras. El modelo de capacitación educativo – preventivo prepara a estos educadores en la prevención de problemas derivados de la situación social de los escolares, logra que el profesor general integral ponga en práctica formas de actuación, para trabajar con el adolescente y su familia y puedan enfrentar determinados problemas grupales. A partir de esta perspectiva educativa - preventiva pretendemos que el profesor general integral eduque a las y los adolescentes en relaciones de equidad, colaboración, flexibilidad, solidaridad, ayuda mutua y respeto a la diferencia, garantizando un modelo más humano, solidario y tolerante que propicie mejor comunicación y relaciones interpersonales entre profesor, adolescentes y padres. En los anexos que se incluyen, no solo el profesor general integral de la secundaria básica contará con materiales potencialmente significativos, que integran toda la información que se requiere para desarrollar su labor educativa - preventiva, sino también que están al alcance de cualquier educador de otro tipo de enseñanza. El lector encontrará el empleo del término alumno/a y menor, estos el autor lo utiliza para referirse a las y los adolescentes comprendidos entre los 12 y 14 años.
Doping-dependent magnetization plateaux in p-merized Hubbard chains
Creators: name: Cabra, D. C.
name: De Martino, A.
name: Honecker, A.
name: Pujol, P.
name: Simon, P.
Publisher: name: arXiv
Year: 1999
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We study zero-temperature Hubbard chains with periodically modulated hopping at arbitrary filling n and magnetization m. We show that the magnetization curves have plateaux at certain values of m which depend on the periodicity p and the filling. At commensurate filling n a charge gap opens and then magnetization plateaux correspond to fully gapped situations. However, plateaux also arise in the magnetization curves at fixed n between the commensurate values and then the plateau-value of of m depends continuously on n and can thus also become irrational. In particular for the case of dimerized hopping (p=2) and fixed doping we find that a plateau appears at m=1-n. In this case, there is still a gapless mode on the plateau leading to thermodynamic behavior which is different from a completely gapped situation.
description: 9 pages REVTeX, 3 PostScript figures included using psfig.sty; this is the final version to appear in Phys. Lett. A; substantial changes: Lanczos part removed to gain space for further explanations (refer to original version for details on the numerics)
Unlocking Business Potential through Digital Transformation: Leveraging AI and Design for Enhanced Performance
Creators: name: Ubaid, Muhammad
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 330305
subject: Design management
classificationCode: 330310
subject: Interaction and experience design
classificationCode: 460201
subject: Artificial life and complex adaptive systems
classificationCode: 350303
subject: Business information systems
classificationCode: 350302
subject: Business information management (incl. records, knowledge and intelligence)
classificationCode: 350304
subject: Business systems in context

description: Abstract  This study explores the relationship between artificial intelligence, design thinking, and business performance in the context of digital transformation. The population studied consisted of hundred respondents, who were selected using a convenience sampling technique. Primary data were collected through a comprehensive questionnaire distributed via Google Forms and physical surveys. The questionnaire was designed using validated scales adapted from prior studies to ensure the robustness of the data. Cronbach's alpha was utilized to test the reliability and confirmed the internal consistency of the scales. Hypotheses were tested using the Hayes Process Macro installed and run in SPSS, allowing a more rigorous examination of direct, indirect, and moderating effects. This study uses a quantitative research design with a cross-sectional approach to assess the relationships between AI, design thinking, and business performance. The results show that AI can significantly automate business processes, facilitate decision-making, and improve operations. Analogous to this, design thinking came out as the mediator for innovation and aligning technology solutions with customer needs. Altogether, these aspects ensure better business outcomes through improved revenue, customer satisfaction, and innovation capacity. It's evident from the findings of this study that strategic operations in business can incorporate AI and design thinking with enormous transformative potential. In such a manner, valuable knowledge for practitioners and researchers in the domain of digital transformation can be derived from it.
title: Malignancy and hospitalised infections in patients with RA treated with abatacept and other DMARDs: results from a 10-year international post-approval study
Creators: name: Simon, Teresa A.
name: Suissa, Samy
name: Skovron, Mary Lou
name: Frisell, Thomas
name: Askling, Johan
name: Michaud, Kaleb
name: Pedro, Sofia
name: Strangfeld, Anja
name: Meissner, Yvette
name: Boers, M.
name: Lacaille, Diane
name: Hochberg, Marc
name: Hoffman, Veena
name: Gomez, Andres
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Background: The global post-marketing epidemiology programme for abatacept consists of observational studies based on registries and healthcare claims databases to assess malignancy and infection risks associated with abatacept treatment vs conventional synthetic (cs)DMARDs and other biologic (b) or[for full text, please go to the a.m. URL]
description: 47. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 33. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 29. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Towards a Computational Workflow for Studying the Effects of Climate Change on Wind Loads on High-Rise Buildings in Urban Areas
Creators: name: Teran, Alfonso S.
name: Agrawal, Shreya
name: Naderian, Hamidreza
name: Wong, Jack K.
name: Song, Jie
name: Mercan, Oya
name: Kushner, Paul J.
name: Mardukhi, Jamil
name: Zhang, Xuebin
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Structures in the built environment that are serviceable under current climate conditions may experience problems in the coming decades as wind loads respond to anthropogenic climate change. Given the great uncertainty in the ability of current climate models to represent winds in the atmospheric boundary layer and the consequent uncertainty in the projection of future wind conditions, there is a need to formulate flexible adaptation strategies that mitigate the effects of climate change in urban regions. The present work thus proposes a multi-disciplinary workflow to investigate climate change-associated wind load effects on the built environment. As an application, projected, statistically downscaled surface wind information from global climate models is used to estimate future design wind speed for Toronto and Vancouver. CFD simulations are then performed on a building in downtown Toronto, under different projected wind scenarios. Wind loads on the building under different projected wind conditions are quantified and compared with the load associated with the National Building Code of Canada (NBCC) design wind speed. Using the proposed workflow, it was found that some climate models suggest reduced wind loads in the future (2071–2100) for buildings in Toronto, while others suggest the opposite. This cross-disciplinary workflow seeks to translate the range of projected effects of climate change into actionable knowledge useful for building design. This will deliver sustainability and resiliency-focused design, as well as retrofit recommendations for decision-makers.
title: Power doppler ultrasound in predicting the radiographic damage in patients with rheumatoid arthritis
Creators: name: Alekseeva, Olga
name: Smirnov, Aleksandr
name: Volkov, Aleksandr
name: Glukhova, Svetlana
name: Nasonov, Eugene
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Background: Ultrasound (US) changes in early RA are considered as one of the ways of predicting disease outcomes. Objective: To detect power doppler (PD) contribution in evaluation of radiographic RA progression in long term. Methods: 85 RA pts, mean age 53,0 [44,0; 61,0] yrs, mean[for full text, please go to the a.m. URL]
description: 47. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 33. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 29. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Additional file 4: of Tracking of epigenetic changes during hematopoietic differentiation of induced pluripotent stem cells
Creators: name: Cypris, Olivia
name: Frobel, Joana
name: Shivam Rai
name: Franzen, Julia
name: Sontag, Stephanie
name: Goetzke, Roman
name: Toledo, Marcelo Szymanski De
name: Zenke, Martin
name: Wagner, Wolfgang
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Figure S3. Comparison of differentially methylated CpG sites across different cell types. Heatmap of DNAm levels at promoter-associated CpG sites that are either at least 50% hypo- or hypermethylated in (a) iHPCs versus iPSCs (corresponding to Fig. 1c) or in (b) iHPCs versus cord blood-derived CD34+ cells (corresponding to Fig. 2a). DNAm levels are compared between MSCs, iPSCs, iHPCs d20, and cord blood-derived CD34+ cells. The heatmaps were sorted by the mean DNAm levels in MSCs. (PDF 126 kb)
BioExcel Webinar #85: Modelling antibodies in the post-Alphafold era: where are we now? (2025-4-8)
Creators: name: Giulini, Marco
Publisher: name: Zenodo
Year: 2025
Subjects: webinar

description: Antibodies are specialized proteins used by the immune system to eliminate unrecognized, potentially harmful molecules (antigens). Their ability to bind antigens with high specificity makes them an ideal molecule to work with in pharmaceutical research and drug development. However modelling antibodies offers endless challenges from a structural perspective, which have been only partially addressed by the recent developments in machine learning-based structure prediction (e.g. AlphaFold21, AlphaFold32). These algorithms tend to rely on coevolutionary information, which is missing in both the antibody’s Complementarity-Determining Regions (CDRs) and between the antibody and antigen sequences.

In this talk I will discuss when and how it is possible to obtain accurate structural predictions of these proteins and their complexes. I will demonstrate how integrating experimental data with AI-driven modeling within the BioExcel flagship software HADDOCK3-4  improves prediction accuracy5. Such models can then be used as a starting point for improving the binding properties of the complexes through antibody design.

I will showcase real-world examples of antibody structural prediction challenges, focusing on cases where pure machine learning-based prediction is unsuccessful.

References

Highly accurate protein structure prediction with AlphaFold J Jumper et al Nature 596 (7873), 583-589

Accurate structure prediction of biomolecular interactions with AlphaFold 3. J Abramson et al Nature 630.8016 (2024): 493-500

HADDOCK: a protein-protein docking approach based on biochemical or biophysical information C Dominguez, R Boelens, AMJJ Bonvin Journal of the American Chemical Society 125 (7), 1731-1737

The HADDOCK2.4 Web Server: A Leap Forward in Integrative Modelling of Biomolecular Complexes. Honorato, R. V. et al. Nature protocols 19 (11), 3219-3241

Towards the accurate modelling of antibody-antigen complexes from sequence using machine learning and information-driven docking M Giulini et al Bioinformatics 40 (10), btae583
Gromov-Witten Invariants via Algebraic Geometry
Creators: name: Katz, Sheldon
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Algebraic Geometry (math.AG)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: Calculations of the number of curves on a Calabi-Yau manifold via an instanton expansion do not always agree with what one would expect naively. It is explained how to account for continuous families of instantons via deformation theory and excess intersection theory. The essential role played by degenerate instantons is also explained. This paper is a slightly expanded version of the author's talk at the June 1995 Trieste Conference on S-Duality and Mirror Symmetry.
description: 15 pages, LaTeX (references added to revised version)
title: Aboriginal and Torres Strait Islander Stolen Generations aged 50 and over: updated analyses for 2018–19
titleType: Subtitle
Creators: name:  Australian Institute of Health and Welfare
Publisher: name: Australian Institute of Health and Welfare
Year: 2021

description: This report provides estimates of and analysis of comparative differences for the Stolen Generations survivors who were aged 50 and over in a 2018–19 survey. They were more likely to be worse off than other Indigenous Australians of the same age on a range of health and socioeconomic outcomes. The findings in the report will be useful to assess the needs of the Stolen Generations and their families.
Lesen und Leseunterricht in der Berufsfachschule: Empirische Untersuchung zur Perspektive von Berufsfachschullehrpersonen auf Lesefähigkeiten von Berufslernenden aus dem Berufsfeld «Gesundheit und Soziales»
Creators: name: Sterel, Saskia
Publisher: name: Zenodo
Year: 2021
Subjects: Lesefähigkeit
Lesekompetenz
Berufsfachschule
Dissertation

description: Die Studie untersuchte, wie Berufsfachschullehrpersonen aus dem Berufsfeld «Gesundheit und Soziales», die Lesefähigkeiten von Lernenden einschätzen und fördern. Damit verbunden ist die übergeordnete Frage, über welchen Begriff von «Lesekompetenz» die Befragten verfügen. In zwei Erhebungen wurde die Perspektive auf die Lesefähigkeiten qualitativ erfasst. Das Mehrebenenmodell des Lesens von Rosebrock & Nix (2020) bildete dafür die Grundlage. Dazwischen wurden die Befragten in das Jugend-Diagnose-Tools JuDiT® eingeführt. Damit können die Lesefähigkeiten von Berufslernenden diagnostizieren werden. Es zeigte sich, dass die Lehrpersonen sich bei der Einschätzung der Lesefähigkeiten und bei der Leseförderung vor allen auf die kognitiven Anforderungen des Leseaktes stützen. Die Beteiligung der Lesesubjekte und vor allem die Kommunikation im Anschluss an Texte spielt dabei eine untergeordnete Rolle. Als die Herausforderung hat sich die individuelle Leseförderung herausgestellt. (English version) The study investigated how vocational school teachers who teach students in the vocational field of «health and social work» assess and promote the reading skills of learners. Linked to this is the overarching question of what concept of «reading competence» the respondents have. In two surveys, the perspective on reading skills was surveyed by means of qualitative methods, with the multi-level model of reading by Rosebrock & Nix (2020) serving as the basis. Between the two suveys, the respondents were introduced to the JuDiT® youth diagnostic tool which can be used to diagnose the reading skills of vocational learners. It was found that teachers who assess reading skills and promote reading primarily fo-cus on the cognitive demands of the reading act. The participation of the reading subjects and especially the communication following the reading of texts play a minor role. Individual reading promotion has turned out to be the challenge.
description: +repphzhbib2021A
title: Voraussage der Schubrate mittels Multi-Biomarker Disease Activity Score und Autoantikörperstatus in RA-Patienten unter DMARD-Dosisreduktion – ein Update der RETRO-Studie
Creators: name: Hagen, Melanie
name: Tascilar, Koray
name: Reiser, Michaela
name: Valor Mendez, Larissa
name: Kleyer, Arnd
name: Hueber, Axel
name: Manger, Bernhard
name: Rech, Jürgen
name: Schett, Georg
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Klinische Remission stellt das wichtigste Therapieziel bei Patienten mit rheumatoider Arthritis (RA) dar. Durch die Entwicklung und den ubiquitären Einsatz hochpotenter disease modifying anti-rheumatic drugs (DMARD), erreicht inzwischen etwa die Hälfte aller behandelten RA-Patienten[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 47. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 33. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 29. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Additional file 2: of Tracking of epigenetic changes during hematopoietic differentiation of induced pluripotent stem cells
Creators: name: Cypris, Olivia
name: Frobel, Joana
name: Shivam Rai
name: Franzen, Julia
name: Sontag, Stephanie
name: Goetzke, Roman
name: Toledo, Marcelo Szymanski De
name: Zenke, Martin
name: Wagner, Wolfgang
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Figure S2. Enrichment of hyper- and hypomethylated CpG sites in iPSC-derived HPCs. Changes in DNA methylation (delta mean β value > 0.5 or
Transfer matrix eigenvalues of the anisotropic multiparametric U model
Creators: name: Links, J.
name: Foerster, A.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: A multiparametric extension of the anisotropic U model is discussed which maintains integrability. The R-matrix solving the Yang-Baxter equation is obtained through a twisting construction applied to the underlying Uq(sl(2|1)) superalgebraic structure which introduces the additional free parameters that arise in the model. Three forms of Bethe ansatz solution for the transfer matrix eigenvalues are given which we show to be equivalent.
description: 26 pages, no figures, LaTeX
Sitio Web para el trabajo educativo-preventivo en la Enseñanza Secundaria Básica
Creators: name: Martínez Ibarra, Oriniel
Publisher: name: figshare
Year: 2021
Subjects: subject: Education
subject: 130106 Secondary Education
subject: FOS: Educational sciences

description: En la Enseñanza Secundaria Básica el adolescente se convierte en el centro de todo el proceso que se realiza en la escuela; donde la efectividad del trabajo educativo-preventivo constituye un elemento primordial para lograr una formación integral en estos individuos. Sin embargo, se constató por el autor que los profesores generales integrales no han logrado ser efectivos en este tipo de trabajo. Ello se corrobora mediante los resultados obtenidos con el empleo de diferentes métodos e instrumentos investigativos aplicados a los docentes que atienden el séptimo y noveno grado de la Secundaria Básica Enrique Galarraga del municipio La Habana Vieja, tomando como muestra a estos docentes. Esto motivó el presente trabajo, en el que se elaboró un Sitio Web para contribuir a la efectividad del trabajo educativo-preventivo en la Enseñanza Secundaria Básica. Pretende ofrecer al profesor general integral herramientas para este tipo de trabajo, desde una concepción educativa que tiene como elemento la relación de ayuda al estudiante, tan necesaria, y para la que, paradójicamente, se encuentran poco entrenados. Según su funcionalidad y el interés educativo, el sitio responde a las Webs temáticos. Su navegación es fácil y atractiva, teniendo en cuenta las potencialidades que brindan las tecnologías informáticas.
Additional file 1: of Genetics of heart rate in heart failure patients (GenHRate)
Creators: name: Evans, Kaleigh
name: Wirtz, Heidi
name: Li, Jia
name: She, Ruicong
name: Maya, Juan
name: Gui, Hongsheng
name: Hamer, Andrew
name: Depre, Christophe
name: Lanfear, David
Publisher: name: figshare
Year: 2019
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Mental Health

description: Table S1. Loci from of other GWAS studies tested in HFrEF patients. Table S2. Additional GWAS results of potential interest (P < 10− 5) from model 1 (n = 1043; AA = 520, white = 523). Table S3. Association of genes with heart rate in EF patients (from gene-wise analysis). Table S4. Classification of genes of interest from gene-wise analysis. Table S5. Sensitivity analysis of HR an ordinal variable, n = 1043 (AA 520, EA 523). Table S6. Top 20 SNPs from 520 AA patients: model 1 (SNP + race + kinship). Table S7. Top 20 SNPs from 523 EA patients: model 1 (SNP + race + kinship) (DOCX 59 kb)
Pseudopodosira calyciflos Kanaya 1963
Creators: name: Williams, David M.
name: Sims, Pat A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Chromista
Ochrophyta
Bacillariophyceae
Melosirales
Pseudopodosiraceae
Pseudopodosira
Pseudopodosira calyciflos

description: Pseudopodosira calyciflos (Tempère & Brun in Brun & Tempère) Kanaya 1963: 24
 TYPE LOCALITY:— Limestone clay from Yedo (Tokyo), Japan (holotype: Brun & Tempère 1889: pl. 4, fig. 11b – specimen in pl. 4, fig. 11a “was included as pertaining to a material found alive in the Sandwich Islands (Hawaiian Islands)” (Sar et al. 2017: 250).
 Basionym: Porodiscus calyciflos Tempère & Brun in Brun & Tempère 1889: 50, pl. 4, fig. 11b
 Synonym: Pyrgodiscus calyciflos (Tempère & Brun in Brun & Tempère) De Toni 1894: 1011
 TYPE:— JAPAN, “Yedo [Tokyo] (Miocene)”, holotype: illustration in Brun & Tempère (1889: pl. 4, fig. 11b, see Sar et al. 2017: 247, 250).
MATERIAL EXAMINED:
 HAWAII, BM 60030! (“Sandwich Is. | Pyrgodiscus calyciflos | Wynne Baxter 6941”, Tempère slide), BM Adams F1043! (“Sandwich | J. Tempère) JAPAN, BM 62150! (“Fossil Marin | Senday, Japan | E. Thum ex Baker”);
description: Published as part of Williams, David M. & Sims, Pat A., 2023, Notes on the diatom collection of the Natural History Museum, London (BM) VII: An account of some original specimens of Pyrgodiscus (Bacillariophyta) with notes on Stephanogonia (Bacillariophyta), pp. 213-229 in Phytotaxa 589 (3) on page 222, DOI: 10.11646/phytotaxa.589.3.1, http://zenodo.org/record/7776942
La atención a la diversidad educativa en el proceso de enseñanza-aprendizaje durante la práctica laboral-investigativa de los estudiantes de carreras pedagógicas en la secundaria básica
Creators: name: Martínez Ibarra, Oriniel
Publisher: name: figshare
Year: 2021
Subjects: subject: Education
subject: 130106 Secondary Education
subject: FOS: Educational sciences

description: La investigación tiene como objetivo diseñar un modelo didáctico para la atención a la diversidad educativa en el proceso de enseñanza-aprendizaje durante la práctica laboral-investigativa de los estudiantes de carreras pedagógicas en la escuela secundaria básica, a partir de uno de los principios de la educación cubana: la vinculación del estudio con el trabajo, principio que se sostiene en la teoría del conocimiento marxista-leninista. Se sistematizan los fundamentos teórico y metodológico para la atención a la diversidad educativa como problema profesional en el proceso de enseñanza-aprendizaje, que los estudiantes-practicantes deberán aprender a resolver en la práctica laboral-investigativa que realizan en las escuelas. El resultado teórico-práctico de la investigación consiste en la determinación e integración de los componentes estructurales del modelo didáctico, que permiten la atención a la diversidad educativa en el proceso de enseñanza-aprendizaje, las recomendaciones para su implementación, el programa de entrenamiento para el desarrollo de habilidades profesionales pedagógicas en la atención a la diversidad educativa y un sitio web como recurso didáctico integrador. Estos resultados integrados, contribuyen a la atención individual en el colectivo como parte de la práctica y sus implicaciones desde la Pedagogía y la Didáctica en la formación profesional pedagógica, en correspondencia con las exigencias del modelo general del egresado de las carreras pedagógica
title: Phagozytose-Aktivität und IL-1ß-Produktion von Monozyten und Makrophagen nach Stimulation mit Porphiromonas gingivalis bei Patienten mit rheumatoider Arthritis
Creators: name: Radushev, Veselina
name: Seifert, Olga
name: Rossol, Manuela
name: Wagner, Ulf
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die rheumatoide Arthritis (RA) ist die häufigste entzündliche Gelenkerkrankung, die ca. 1-2% der Weltbevölkerung betrifft und mit Entstehung von Antikörper gegen cyclische citrullinierte Peptide (ACPA) assoziiert ist. Porphiromonas gingivalis ist ein obligat anaerobes,[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 47. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 33. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 29. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Optical optimization of a multi-slit extreme ultraviolet spectrograph for global solar corona diagnostics
Creators: name: Feng, Yufei
name: Bai, Xianyong
name: Guo, Sifan
name: Tian, Hui
name: Chan, Lami
name: Deng, Yuanyong
name: Yang, Qi
name: Duan, Wei
name: Zhu, Xiaoming
name: Yang, Xiao
name: Feng, Zhiwei
name: Zhang, Zhiyong
Publisher: name: arXiv
Year: 2024
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The spatial-temporal evolution of coronal plasma parameters of the solar outer atmosphere at global scales, derived from solar full-disk imaging spectroscopic observation in the extreme-ultraviolet band, is critical for understanding and forecasting solar eruptions. We propose a multi-slits extreme ultraviolet imaging spectrograph for global coronal diagnostics with high cadence and present the preliminary instrument designs for the wavelength range from 18.3 to 19.8 nm. The instrument takes a comprehensive approach to obtain global coronal spatial and spectral information, improve the detected cadence and avoid overlapping. We first describe the relationship between optical properties and structural parameters, especially the relationship between the overlapping and the number of slits, and give a general multi-slits extreme-ultraviolet imaging spectrograph design process. Themultilayer structure is optimized to enhance the effective areas in the observation band. Five distantly-separated slits are set to divide the entire solar field of view, which increase the cadence for raster scanning the solar disk by 5 times relative to a single slit. The spectral resolving power of the optical system with an aperture diameter of 150 mm are optimized to be greater than 1461. The spatial resolution along the slits direction and the scanning direction are about 4.4''and 6.86'', respectively. The Al/Mo/B4C multilayer structure is optimized and the peak effective area is about 1.60 cm2 at 19.3 nm with a full width at half maximum of about 1.3 nm. The cadence to finish full-disk raster scan is about 5 minutes. Finally, the instrument performance is evaluated by an end-to-end calculation of the system photon budget and a simulation of the observational image and spectra. Our investigation shows that this approach is promising for global coronal plasma diagnostics.
description: This version of the article has been accepted for publication, after peer review (when applicable) but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s10686-024-09961-9
Absence of non-trivial asymptotic scaling in the Kashchiev model of polynuclear growth
Creators: name: Newman, T. J.
name: Volmer, A.
Publisher: name: arXiv
Year: 1996
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: In this brief comment we show that, contrary to previous claims [Bartelt M C and Evans J W 1993 {\it J.\ Phys.\ A} ${\bf 26}$ 2743], the asymptotic behaviour of the Kashchiev model of polynuclear growth is trivial in all spatial dimensions, and therefore lies outside the Kardar-Parisi-Zhang universality class.
description: 3 pages, 4 postscript figures, uses epsf
title: Computer-basierte Analyse der Fingergelenkspaltweite bei Patienten mit einer rheumatoiden Arthritis unter der Therapie mit Certolizumab pegol
Creators: name: Pfeil, Alexander
name: Nussbaum, Anica
name: Renz, Diane
name: Malich, Ansgar
name: Böttcher, Joachim
name: Wolf, Gunter
name: Oelzner, Peter
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die Therapie mit dem TNF-α Blocker Certolizumab Pegol ist eine effektive Therapie in der Behandlung von Patienten mit einer rheumatoiden Arthritis (RA) dar. Eine Beurteilung des radiographischen Schweregrades erfolgt insbesondere anhand der Erfassung der Erosionen und Fingergelenkspaltweise[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 47. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 33. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 29. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
title: ADCO, Ordre cistercien et abbaye de Cîteaux : comptes pour l'ordre (1337-1347), comptes du boursier (1377-1402) (11 H 1160), f. 00276
Creators: name: de la Côte-d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2017
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: comptes

description: Ordre cistercien et abbaye de Cîteaux : comptes pour l'ordre (1337-1347), comptes du boursier (1377-1402), Archives départementales de la Côte-d'Or, (11 H 1160). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Ordre cistercien et abbaye de Cîteaux : comptes pour l'ordre (1337-1347), comptes du boursier (1377-1402), Archives départementales de la Côte-d'Or, (11 H 1160), f. 00276, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: abbaye de Cîteaux