cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Disentangling the impact of cerebrospinal fluid formation and neuronal activity on solute clearance from the brain
Creators: name: Segeroth, Martin
name: Wachsmuth, Lydia
name: Gagel, Mathias
name: Albers, Franziska
name: Hess, Andreas
name: Faber, Cornelius
Publisher: name: University of Muenster, Institutional Repository MIAMI
Year: 2025
Subjects: subject: 610 Medicine and health

description: Background: Despite recent attention, pathways and mechanisms of fluid transposition in the brain are still a matter of intense discussion and driving forces underlying waste clearance in the brain remain elusive. Consensus exists that net solute transport is a prerequisite for efficient clearance. The individual impact of neuronal activity and cerebrospinal fluid (CSF) formation, which both vary with brain state and anesthesia, remain unclear. Methods: To separate conditions with high and low neuronal activity and high and low CSF formation, different anesthetic regimens in naive rat were established, using Isoflurane (ISO), Medetomidine (MED), acetazolamide or combinations thereof. With dynamic contrast-enhanced MRI, after application of low molecular weight contrast agent (CA) Gadobutrol to cisterna magna, tracer distribution was monitored as surrogate for solute clearance. Simultaneous fiber-based Ca2+-recordings informed about the state of neuronal activity under different anesthetic regimen. T2-weighted MRI and diffusion-weighted MRI (DWI) provided size of subarachnoidal space and aqueductal flow as surrogates for CSF formation. Finally, a pathway and mechanism-independent two-compartment model was introduced to provide a measure of efficiency for solute clearance from the brain. Results: Anatomical imaging, DWI and Ca2+-recordings confirmed that conditions with distinct levels of neuronal activity and CSF formation were achieved. A sleep-resembling condition, with reduced neuronal activity and enhanced CSF formation was achieved using ISO+MED and an awake-like condition with high neuronal activity using MED alone. CA distribution in the brain correlated with the rate of CSF formation. The cortical brain state had major influence on tracer diffusion. Under conditions with low neuronal activity, higher diffusivity suggested enlargement of extracellular space, facilitating a deeper permeation of solutes into brain parenchyma. Under conditions with high neuronal activity, diffusion of solutes into parenchyma was hindered and clearance along paravascular pathways facilitated. Exclusively based on the measured time signal curves, the two-compartment model provided net exchange ratios, which were significantly larger for the sleep-resembling condition than for the awake-like condition. Conclusions: Efficiency of solute clearance in brain changes with alterations in both state of neuronal activity and CSF formation. Our clearance pathway and mechanism agnostic kinetic model informs about net solute transport, solely based on the measured time signal curves. This rather simplifying approach largely accords with preclinical and clinical findings.
description: Finanziert über die DEAL-Vereinbarung mit Wiley, Springer oder Elsevier 2019–2023.
Tenthredo (Tenthredella) stigma
Creators: name: Lee, Jong-Wook
name: Park, Jin-Kyung Choi and Bia
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Tenthredinidae
Tenthredo
Tenthredo stigma

description: 379. Tenthredo (Tenthredella) stigma (Forsius, 1918)
 ĢḣƞDzḇ (NK: ḎêĦƞDzḇ)
 Tenthredella stigma Forsius, 1918: 149-150.
 Tenthredo amplicapitata Zombori, 1974: 456-458.
 Korean records. Zombori, 1974; Kim et al., 1994; Lee and Ryu, 1996a; Lee et al., 2000; Choi and Ko, 2006; Paek et al., 2010; Ahn et al., 2013; Lyu et al., 2014.
 Host plant. Unknown.
 Distribution. Korea (South, North), China, Russia.
description: Published as part of Lee, Jong-Wook & Park, Jin-Kyung Choi and Bia, 2019, Synoptic list of Symphyta (Hymenoptera) in Korea, pp. 1-96 in Journal of Species Research 8 (1) on page 66, DOI: 10.12651/JSR.2019.8.1.001, http://zenodo.org/record/13137712
Additional file 3 of Analysis of the obstetrician's posture and movements during a simulated forceps delivery
Creators: name: Sorel, Manon
name: Gachon, Bertrand
name: Coste-Mazeau, Perrine
name: Aubard, Yves
name: Pierre, Fabrice
name: Fradet, Laetitia
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified

description: Supplementary Material 3.
Linking the LASLA corpus to the LiLa Knowledge Base of Interoperable Resources for Latin
Creators: name: Fantoli, Margherita
name: Passarotti, Marco
name: Ruffolo, Paolo
name: Longrée, Dominique
Publisher: name: Zenodo
Year: 2022
Subjects: Latin
Linguistic Linked Open Data

description: Slides of the presentation at the 21st International Colloquium on Latin Linguistics. Universidad de Santiago de Compostela. 30th May - 3rd June 2022
Sztuczna inteligencja na wolności?
Creators: name: Kubalica, Tomasz
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 500312
subject: Philosophy of cognition
classificationCode: 460299
subject: Artificial intelligence not elsewhere classified

description: Już niedługo sztuczna inteligencja będzie mogła zastąpić nas w zarezerwowanych dotąd dla ludzi zajęciach takich jak myślenie i decydowanie. Temat budzi wiele kontrowersji i skłania do refleksji oraz pytań na temat sensu korzystania z tak zaawansowanej technologii. Jednym z takich palących zagadnień jest pytanie, czy przyznać sztucznej inteligencji praktyczną autonomię.
Tenthredo (Tenthredina) smithii W. F. Kirby 1882
Creators: name: Lee, Jong-Wook
name: Park, Jin-Kyung Choi and Bia
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Tenthredinidae
Tenthredo
Tenthredo smithii

description: 382. Tenthredo (Tenthredina) smithii W.F. Kirby, 1882
 ọŖDzḇ
 Tenthredo smithii W.F. Kirby, 1882: 320.
 Tenthredo flavida Marlatt, 1898: 500. Primary homonym of Tenthredo flavida Christ, 1791.
 Tenthredella flavicaria Enslin, 1912a: 105. Name for Tenthredo flavida Marlatt, 1898.
 Korean records. Lee et al., 2000; Shinohara, 2002b; Paek et al., 2010; Lyu et al., 2014.
 Host plants. Cardiocrinum cordatum (Thunb.) Makino, Lilium japonicum Thunb., Smilax china L., Smilax sieboldii Miq., Smilax sp., Tricyrtis macropoda Miq.
 Distribution. Korea (South), China, Japan.
description: Published as part of Lee, Jong-Wook & Park, Jin-Kyung Choi and Bia, 2019, Synoptic list of Symphyta (Hymenoptera) in Korea, pp. 1-96 in Journal of Species Research 8 (1) on page 67, DOI: 10.12651/JSR.2019.8.1.001, http://zenodo.org/record/13137712
Tenthredo longipennis
Creators: name: Lee, Jong-Wook
name: Park, Jin-Kyung Choi and Bia
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Tenthredinidae
Tenthredo
Tenthredo longipennis

description: 392. Tenthredo longipennis (Matsumura, 1912)
 ű꼬ƞDzḇ
 Allantus longipennis Matsumura, 1912: 224-225. Tenthredo grandiceps Malaise, 1938: 93-94.
 Korean records. Kim, 1970; Kim, 1980; Kim et al., 1994; Lee and Ryu, 1996a; Lee et al., 2000; Paek et al., 2010; Lyu et al., 2014.
 Host plant. Unknown.
 Distribution. Korea (South), Japan, Russia.
description: Published as part of Lee, Jong-Wook & Park, Jin-Kyung Choi and Bia, 2019, Synoptic list of Symphyta (Hymenoptera) in Korea, pp. 1-96 in Journal of Species Research 8 (1) on page 68, DOI: 10.12651/JSR.2019.8.1.001, http://zenodo.org/record/13137712
Exploiting the (Meta)Data. The LiLa Knowledge Base of Linguistic Resources for Latin Supporting Research in Latin Linguistics
Creators: name: Passarotti, Marco
name: Cecchini, Flavio Massimiliano
name: Franzini, Greta
name: Litta, Eleonora
name: Mambrini, Francesco
name: Moretti, Giovanni
name: Ruffolo, Paolo
name: Sprugnoli, Rachele
name: Testori, Marinella
Publisher: name: Zenodo
Year: 2022
Subjects: Latin
Linguistic Linked Open Data

description: Slides of the presentation at the 21st International Colloquium on Latin Linguistics. Universidad de Santiago de Compostela. 30th May - 3rd June 2022
Additional file 4 of Analysis of the obstetrician's posture and movements during a simulated forceps delivery
Creators: name: Sorel, Manon
name: Gachon, Bertrand
name: Coste-Mazeau, Perrine
name: Aubard, Yves
name: Pierre, Fabrice
name: Fradet, Laetitia
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified

description: Supplementary Material 4.
title: Bougainville revisited : understanding the crisis and U-Vistract through an ethnography of everyday life in Nagovisi
Creators: name: Kenema, Simon
Publisher: name: University of St Andrews
publisherIdentifier: https://ror.org/02wn5qz54
publisherIdentifierScheme: ROR
Year: 2015

description: This thesis offers an ethnographic study of everyday life in Nagovisi of Southwest Bougainville. The study focuses on aspects of how the Nagovisi construe social relations with a specific focus on vernacular categories and ideologies. The thesis deals with ideas about land, perceptions about the fluid nature of Nagovisi sociality, movement, and U-Vistract. The study is primarily based on thirteen months of field research I conducted in the Nagovisi between September 2011 and November of 2012. Through the exploration of the various thematic issues in the individual chapters the thesis offers a comparative scope for a tangential re-evaluation of the mine related crisis on the island. The focus on Noah Musinku and the Kingdom of Papala further illustrates this comparative scope by drawing an analogy between Panguna and U-Vistract and the complex entanglements and interrelationships between ideas relating to land, history, myth, relatedness, social unpredictability, and notions about wealth. It deals with the question of how persons, land and knowledge are mutually constitutive, and how each can affect the other as a result of history, and movement in time and space. By focusing on Nagovisi notions of the unpredictability of talk, knowledge, and the implication this bears on the nature of how people relate to each other and different places the thesis deals with what has long been proven a recalcitrant problem in PNG anthropological literature in which local life worlds are characterised by a fluidity of social forms.
sj-docx-1-tej-10.1177_20417314221132093 – Supplemental material for A new cell-free therapeutic strategy for liver regeneration: Human placental mesenchymal stem cell-derived extracellular vesicles
Creators: name: Li, Ting
name: Fu, Yu
name: Guo, Zeyi
name: Zhu, Honglei
name: Liao, Hangyu
name: Niu, Xiaoge
name: Zhou, Lin
name: Fu, Shunjun
name: Li, Yang
name: Li, Shao
name: Wang, Lujia
name: Zheng, Yizhou
name: Feng, Lei
name: Gao, Yi
name: He, Guolin
Publisher: name: SAGE Journals
Year: 2022
Subjects: Dentistry not elsewhere classified
Biological Sciences not elsewhere classified

description: Supplemental material, sj-docx-1-tej-10.1177_20417314221132093 for A new cell-free therapeutic strategy for liver regeneration: Human placental mesenchymal stem cell-derived extracellular vesicles by Ting Li, Yu Fu, Zeyi Guo, Honglei Zhu, Hangyu Liao, Xiaoge Niu, Lin Zhou, Shunjun Fu, Yang Li, Shao Li, Lujia Wang, Yizhou Zheng, Lei Feng, Yi Gao and Guolin He in Journal of Tissue Engineering
sj-docx-2-hpp-10.1177_15248399231221160 – Supplemental material for Parents’ and Caregivers’ Support for in-School COVID-19 Mitigation Strategies: A Socioecological Perspective
Creators: name: Prichett, Laura
name: Berry, Andrea A.
name: Calderon, Gabriela
name: Wang, June
name: Hager, Erin R.
name: Klein, Lauren M.
name: Edwards, Lorece V.
name: Liu, Yisi
name: Johnson, Sara B.
Publisher: name: SAGE Journals
Year: 2024
Subjects: subject: Health and Community Services
subject: Public Health and Health Services not elsewhere classified
subject: Sociology
subject: FOS: Sociology

description: Supplemental material, sj-docx-2-hpp-10.1177_15248399231221160 for Parents’ and Caregivers’ Support for in-School COVID-19 Mitigation Strategies: A Socioecological Perspective by Laura Prichett, Andrea A. Berry, Gabriela Calderon, June Wang, Erin R. Hager, Lauren M. Klein, Lorece V. Edwards, Yisi Liu and Sara B. Johnson in Health Promotion Practice
Tenthredo melanotarsus Cameron 1876
Creators: name: Lee, Jong-Wook
name: Park, Jin-Kyung Choi and Bia
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Tenthredinidae
Tenthredo
Tenthredo melanotarsus

description: 393. Tenthredo melanotarsus Cameron, 1876 ºflDzḇ
 Tenthredo melanotarsus Cameron, 1876: 467.
 Tenthredo melanotarsis Konow, 1898d: 89. Name for Tenthredo melanotarsus Cameron, 1876.
 Korean records. Zombori, 1974; Kim et al., 1994; Lee and Ryu, 1996a; Lee et al., 2000; Paek et al., 2010; Lyu et al., 2014.
 Host plant. Unknown.
 Distribution. Korea (North), Bhutan, China, India.
description: Published as part of Lee, Jong-Wook & Park, Jin-Kyung Choi and Bia, 2019, Synoptic list of Symphyta (Hymenoptera) in Korea, pp. 1-96 in Journal of Species Research 8 (1) on page 68, DOI: 10.12651/JSR.2019.8.1.001, http://zenodo.org/record/13137712
Additional file 5 of Analysis of the obstetrician's posture and movements during a simulated forceps delivery
Creators: name: Sorel, Manon
name: Gachon, Bertrand
name: Coste-Mazeau, Perrine
name: Aubard, Yves
name: Pierre, Fabrice
name: Fradet, Laetitia
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified

description: Supplementary Material 5.
Machina Callida. Corpus-based Latin Language Acquisition and Research
Creators: name: Schulz, Konstantin
name: Beyer, Andrea
Publisher: name: Zenodo
Year: 2022
Subjects: language learning
vocabulary acquisition
Latin language
computer-assisted language learning

description: Slides for a talk at Sunoikis Digital Classics Summer 2022: https://github.com/SunoikisisDC/SunoikisisDC-2021-2022/wiki/SunoikisisDC-Summer-2022-Session-6
description: Funded by the German Research Foundation (DFG), project number 316618374
sj-docx-1-isp-10.1177_00207640231214979 – Supplemental material for Similar and different? A cross-cultural comparison of the prevalence, course of and factors associated with suicidal thoughts and behaviors in first-episode psychosis in Chennai, India and Montreal, Canada
Creators: name: Sicotte, Roxanne
name: Abdel-Baki, Amal
name: Mohan, Greeshma
name: Rabouin, Daniel
name: Malla, Ashok
name: Padmavati, Ramachandran
name: Moro, Laura
name: Joober, Ridha
name: Rangaswamy, Thara
name: Iyer, Srividya N.
Publisher: name: SAGE Journals
Year: 2024
Subjects: Psychology not elsewhere classified
Psychiatry (incl. Psychotherapy)

description: Supplemental material, sj-docx-1-isp-10.1177_00207640231214979 for Similar and different? A cross-cultural comparison of the prevalence, course of and factors associated with suicidal thoughts and behaviors in first-episode psychosis in Chennai, India and Montreal, Canada by Roxanne Sicotte, Amal Abdel-Baki, Greeshma Mohan, Daniel Rabouin, Ashok Malla, Ramachandran Padmavati, Laura Moro, Ridha Joober, Thara Rangaswamy and Srividya N. Iyer in International Journal of Social Psychiatry
sj-docx-2-isp-10.1177_00207640231217173 – Supplemental material for Outcomes of psychosocial interventions for homeless individuals with mental illness: A systematic review
Creators: name: Roy, Roniyamol
name: Raman, K Janaki
name: Raj, E Aravind
name: Varambally, Shivarama
Publisher: name: SAGE Journals
Year: 2024
Subjects: Psychology not elsewhere classified
Psychiatry (incl. Psychotherapy)

description: Supplemental material, sj-docx-2-isp-10.1177_00207640231217173 for Outcomes of psychosocial interventions for homeless individuals with mental illness: A systematic review by Roniyamol Roy, K Janaki Raman, E Aravind Raj and Shivarama Varambally in International Journal of Social Psychiatry
Additional file 6 of Analysis of the obstetrician's posture and movements during a simulated forceps delivery
Creators: name: Sorel, Manon
name: Gachon, Bertrand
name: Coste-Mazeau, Perrine
name: Aubard, Yves
name: Pierre, Fabrice
name: Fradet, Laetitia
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified

description: Supplementary Material 6.
sj-doc-1-psp-10.1177_01461672231218746 – Supplemental material for Effort Expenditure Increases Risk-Taking for Improbable Rewards
Creators: name: Jiang, Huiping
name: Zheng, Ya
Publisher: name: SAGE Journals
Year: 2024
Subjects: Psychology not elsewhere classified

description: Supplemental material, sj-doc-1-psp-10.1177_01461672231218746 for Effort Expenditure Increases Risk-Taking for Improbable Rewards by Huiping Jiang and Ya Zheng in Personality and Social Psychology Bulletin
sj-pdf-2-tar-10.1177_17534666231221750 – Supplemental material for Referral rates and barriers to lung transplantation based on pulmonary function criteria in interstitial lung diseases: a retrospective cohort study
Creators: name: Deri, Ofir
name: Ovadia, David
name: Huszti, Ella
name: Peled, Michael
name: Saute, Milton
name: Hod, Tammy
name: Onn, Amir
name: Seluk, Lior
name: Furie, Nadav
name: Shafran, Inbal
name: Mass, Ronen
name: Chatterji, Sumit
name: Levy, Liran
Publisher: name: SAGE Journals
Year: 2024
Subjects: Aged Health Care
Pharmacology and Pharmaceutical Sciences not elsewhere classified
Respiratory Diseases

description: Supplemental material, sj-pdf-2-tar-10.1177_17534666231221750 for Referral rates and barriers to lung transplantation based on pulmonary function criteria in interstitial lung diseases: a retrospective cohort study by Ofir Deri, David Ovadia, Ella Huszti, Michael Peled, Milton Saute, Tammy Hod, Amir Onn, Lior Seluk, Nadav Furie, Inbal Shafran, Ronen Mass, Sumit Chatterji and Liran Levy in Therapeutic Advances in Respiratory Disease
Tenthredo mortivaga Marlatt 1898
Creators: name: Lee, Jong-Wook
name: Park, Jin-Kyung Choi and Bia
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Tenthredinidae
Tenthredo
Tenthredo mortivaga

description: 394. Tenthredo mortivaga Marlatt, 1898 ḒĀƞệDzḇ
 Tenthredo mortivaga Marlatt, 1898: 501-502. Tenthredopsis basalis Matsumura, 1912: 46-47.
 Korean records. Lee et al., 1995b; Lee and Ryu, 1996a; Lee et al., 2000; Paek et al., 2010; Lyu et al., 2014.
 Host plants. Cerastium caespitosum var. ianthes F.N. Williams, Stellaria aquatica (L.) Scop., Stellaria media (L.) Vill.
 Distribution. Korea (South), China, Japan.
description: Published as part of Lee, Jong-Wook & Park, Jin-Kyung Choi and Bia, 2019, Synoptic list of Symphyta (Hymenoptera) in Korea, pp. 1-96 in Journal of Species Research 8 (1) on page 68, DOI: 10.12651/JSR.2019.8.1.001, http://zenodo.org/record/13137712
Additional file 7 of Analysis of the obstetrician's posture and movements during a simulated forceps delivery
Creators: name: Sorel, Manon
name: Gachon, Bertrand
name: Coste-Mazeau, Perrine
name: Aubard, Yves
name: Pierre, Fabrice
name: Fradet, Laetitia
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified

description: Supplementary Material 7.
Discovery of novel inhibitor via molecular dynamics simulations against D-alanyl-D-alanine carboxypeptidase of Enterobacter cloacae
Creators: name: Ahmad, Faisal
name: Ismail, Saba
name: Azam, Syed Sikander
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Antibiotics resistance by bacterial pathogens is a major concern to public health worldwide resulting in high health care costs and rising mortality. Subtractive proteomics prioritized D-alanyl-D-alanine carboxypeptidas (DacB) enzyme from Enterobacter cloacae ATCC 13047 as a potential candidate for drugs designing to block pathogen cell wall biosynthesis. Virtual screening of an antibacterial library against the target unraveled a hit compound (2-[(1-methylsulfonylpiperidin-3-yl)methyl]-6-(1H-pyrazol-4-yl) pyrazine) showing high affinity and stability with the target. The N-methyl-N-propyl-methanesulfonamide of the compound is seen as a closed affinity towards domain involving strong hydrogen bonds with Ser41, Lys44, Ser285, and Asn287. The 4-methyl-1H-pyrazole is posed towards the open cavity of domain I and II and formed hydrophobic and hydrophilic contacts. The system is highly stable with average carbon-alpha deviations of 1.69 Å over trajectories of 400-ns. Three vital residues projected: Arg437, Arg438 and Leu400 from enzyme pocket via Radial distribution function (RDF) assay, which actively engaged the inhibitor. Further confirmation is done by estimating binding free energies, which confirms the very low delta energy of −7.24 kcal/mol in Generalized Born (GB) method and −7.4363 kcal/mol in Poisson-Boltzmann (PB) method. WaterSwap calculations were performed that revealed the energies highly converged, an agreement on good system stability. Lastly, three DacB mutants were created to investigate the role of functional active residues and a decline in binding affinity of the residues was noticed. These computational results provide a gateway for experimentalists to further confirm their efficacy both in-vitro and in-vivo.
sj-docx-1-jmh-10.1177_15579883231215153 – Supplemental material for “In My Mind, It Was Just Temporary”: A Qualitative Study of the Impacts of Cancer on Men and Their Strategies to Cope
Creators: name: Montiel, Corentin
name: Bedrossian, Nathalie
name: Myre, André
name: Kramer, Asher
name: Piché, Alexia
name: Mcdonough, Meghan H.
name: Sabiston, Catherine M.
name: Petrella, Anika
name: Gauvin, Lise
name: Doré, Isabelle
Publisher: name: SAGE Journals
Year: 2024
Subjects: Health and Community Services
Nursing not elsewhere classified
Public Health and Health Services not elsewhere classified

description: Supplemental material, sj-docx-1-jmh-10.1177_15579883231215153 for “In My Mind, It Was Just Temporary”: A Qualitative Study of the Impacts of Cancer on Men and Their Strategies to Cope by Corentin Montiel, Nathalie Bedrossian, André Myre, Asher Kramer, Alexia Piché, Meghan H. Mcdonough, Catherine M. Sabiston, Anika Petrella, Lise Gauvin and Isabelle Doré in American Journal of Men's Health
Additional file 8 of Analysis of the obstetrician's posture and movements during a simulated forceps delivery
Creators: name: Sorel, Manon
name: Gachon, Bertrand
name: Coste-Mazeau, Perrine
name: Aubard, Yves
name: Pierre, Fabrice
name: Fradet, Laetitia
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified

description: Supplementary Material 8.
Tenthredo providens F. Smith 1874
Creators: name: Lee, Jong-Wook
name: Park, Jin-Kyung Choi and Bia
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Tenthredinidae
Tenthredo
Tenthredo providens

description: 395. Tenthredo providens F. Smith, 1874 날fflŖLjDzḇ
 Tenthredo providens F. Smith, 1874: 382.
 Tenthredo providentia Enslin, 1920: 65-66, 90.
 Korean records. Cho, 1961; Kim, 1963; Zool. Soc. Kor., 1968; Kim, 1970; Kim, 1980; Kim et al., 1994; Lee et al., 1996; Lee and Ryu, 1996a; Lee et al., 2000; Paek et al., 2010; Lyu et al., 2014.
 Host plants. Angelica decursiva (Miq.) Franch. and Sav., Angelica polyclada Franch., Angelica sp., Cryptotaenia canadensis (L.) DC., Cryptotaenia sp., Oenanthe javanica (Blume) DC., Oenanthe sp., Peucedanum sp., Pternopetalum tanakae (Franch. and Sav.) Hand. -Mazz.
 Distribution. Korea (South), Japan.
description: Published as part of Lee, Jong-Wook & Park, Jin-Kyung Choi and Bia, 2019, Synoptic list of Symphyta (Hymenoptera) in Korea, pp. 1-96 in Journal of Species Research 8 (1) on page 68, DOI: 10.12651/JSR.2019.8.1.001, http://zenodo.org/record/13137712
CpG oligodeoxynucleotides and pan-serotype inhibitors control neurotropic Dengue infection in novel immune competent neonatal mouse model
Creators: name: Mendoza, Mirian
name: Ireland, Derek D.C.
name: Lee, Ha-Na
name: Kelly-Baker, Logan
name: Chowdhury, Monica
name: Verthelyi, Daniela
name: Manangeeswaran, Mohanraj
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Dengue virus (DENV) is a growing global public health threat. The lack of symptomatic immune competent animal models for Dengue has hindered the screening and development of effective therapeutics that can be used to control dengue virus replication and thereby control the progression to severe dengue disease. To address this, we established an infection model in neonatal C57BL/6 mice and showed that a systemic Dengue challenge leads to ataxia, seizures, paralysis, and death within 15 days. The virus was found predominantly in the eye and brain where DENV infects neurons but not astrocytes and causes extensive infiltration of macrophages and microglia activation. The response to infection included upregulation of multiple genes linked to interferons (Ifna, Ifnb, Ifng, Irf7, Irf8, Mx1, Stat1 and Bst2), inflammation (Il6,Tnfa), complement (Cfb,C1ra,C2, C3), cytolysis (Gzma, Gzmb, Prf1) consistent with antiviral responses and inflammation together with neuroprotective regulatory signals (Il27, Il10, and stat2). The increased proinflammatory signature was associated downregulation neurodevelopmental genes (Calb2, Pvalb, Olig1 and Olig2). We tested the utility of this mouse model by assessing the protection conferred by direct antivirals JNJ-A07 and ST-148 and host-directed antiviral immunomodulatory CpG oligodeoxynucleotide (ODN), alone or in combination against lethal dengue viral infection. The data showed that immunomodulatory CpG ODN and antiviral JNJ-A07 improved survival of neonatal mice, and protection from lethal neurotropic infection was optimal when treatments were combined. This study suggests that combination of an effective dengue antiviral along with a host directed therapeutic may be a useful strategy to protect against Dengue virus infections.
Discovery of anticancer compound possessing potential to bind γ-secretase catalytic subunit and inhibit notch promoter activity
Creators: name: Singh, Atul Kumar
name: Prajapati, Kumari Sunita
name: Kumar, Shashank
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Gamma secretase (GS) is an important therapeutic target in anticancer drug discovery. Increased GS activity activates notch signaling pathway which is associated with cancer stemness and drug resistance in cancer cells. A total of 69,075 natural and their derivative compounds were screened to identify the lead compound on the basis of in silico GS catalytic domain binding potential and in vitro selective anticancer efficacy. STOCK1N-23234 showed higher dock score (−11.82) compared to DAPT (−9.2) in molecular docking experiment and formed hydrogen bond with the key amino acid (Asp385) involve in catalysis process. Molecular dynamics (MD) simulation parameters (RMSD, RMSF, Rg, SASA and hydrogen bond formation) revealed that the STOTCK1N-23234 formed structurally and energetically stable complex with the GS catalytic domain with lower binding energy (−22.79 kcal/mol) compared to DAPT (−16.22 kcal/mol). STOCK1N-23234 showed better toxicity (up to 60%) against colon and breast cancer cells (HCT-116 and MDA-MB-453) at 1–70 µM concentration. Interestingly, STOCK1N-23234 did not showed cytotoxicity against human normal breast cells (MCF-10A). STOCK1N-23234 treatment significantly decreased sphere formation, notch promoter activity, and transcription of notch target genes (Hes-1 and Hey-1) in HCT-116 cells derived colonosphere. Confocal microscopy revealed that STOTCK1N-23234 treatment at test concentration induced apoptosis related morphological changes, reduced mitochondria membrane potential and increased reactive oxygen species production in HCT-116 cells compared to non-treated cells. In conclusion, STOCK1N-23234 is a novel lead natural anticancer compound which requires in depth validation in cancer preclinical models.
Tenthredo pseudolivacea subsp. omega
Creators: name: Lee, Jong-Wook
name: Park, Jin-Kyung Choi and Bia
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Tenthredinidae
Tenthredo
Tenthredo pseudolivacea
Tenthredo pseudolivacea omega (takeuchi, 1936)

description: 396. Tenthredo pseudolivacea omega (Takeuchi, 1936)
 어ƞẳƞÊDzḇ
 Tenthredella pseudolivacea var. omega Takeuchi, 1936a: 76.
 Korean records. Kim, 1963; Zool. Soc. Kor., 1968; Kim, 1970; Kim et al., 1994; Lee and Ryu, 1996a; Lee et al., 2000; Paek et al., 2010; Lyu et al., 2014.
 Host plant. Unknown.
 Distribution. Korea (South), Japan, Russia.
description: Published as part of Lee, Jong-Wook & Park, Jin-Kyung Choi and Bia, 2019, Synoptic list of Symphyta (Hymenoptera) in Korea, pp. 1-96 in Journal of Species Research 8 (1) on pages 68-69, DOI: 10.12651/JSR.2019.8.1.001, http://zenodo.org/record/13137712
Molecular dynamics simulation as a promising approach for computational study of liquid crystal-based aptasensors
Creators: name: Zahraee, Hamed
name: Arab, Seyed Shahriar
name: Khoshbin, Zahra
name: Taghdisi, Seyed Mohammad
name: Abnous, Khalil
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biophysics
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Computational Biology

description: As a potent computational methodology, molecular dynamics (MD) simulation provides advantageous knowledge about biological compounds from the molecular viewpoint. In particular, MD simulation gives exact information about aptamer strands, such as the short synthetic oligomers, their orientation, binding sites, folding-unfolding state, and conformational re-arrangement. Also, the effect of the different chemicals and biochemicals as the components of aptamer-based sensors (aptasensors) on the aptamer-target interaction can be investigated by MD simulation. Liquid crystals (LCs) as soft substances with characteristics of both solid anisotropy and liquid fluidity are new candidates for designing label-free aptasensors. To now, diverse aptasensors have been developed experimentally based on the optical anisotropy, fluidity, and long-range orientational order of LCs. Here, we represent a computational model of an LC-based aptasensor through a detailed MD simulation study. The different parameters are defined and studied to achieve a comprehensive understanding of the computational design of the LC-based aptasensor, including the density of LCs, their orientation angle, and lognormal distribution in the absence and presence of aptamer strands, both aptamer and target molecules with various concentrations, and interfering substance. As a case study, the tobramycin antibiotic is considered the target molecule for the computational model of the LC-based aptasensor.
Tenthredo pseudolivacea subsp. pseudolivacea Malaise
Creators: name: Lee, Jong-Wook
name: Park, Jin-Kyung Choi and Bia
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Tenthredinidae
Tenthredo
Tenthredo pseudolivacea
Tenthredo pseudolivacea pseudolivacea malaise

description: 397. Tenthredo pseudolivacea pseudolivacea Malaise,
 1931 ẳƞÊDzḇ (NK: 나ŖDzḇ)
 Tenthredo pseudolivacea Malaise, 1931b: 104-105.
 Korean records. Doi, 1938; Chu, 1969; Lee et al., 2000; Paek et al., 2010; Ahn et al., 2013; Lyu et al., 2014.
 Host plant. Unknown.
 Distribution. Korea (South, North), China, Japan, Russia.
description: Published as part of Lee, Jong-Wook & Park, Jin-Kyung Choi and Bia, 2019, Synoptic list of Symphyta (Hymenoptera) in Korea, pp. 1-96 in Journal of Species Research 8 (1) on page 69, DOI: 10.12651/JSR.2019.8.1.001, http://zenodo.org/record/13137712
Tuning the Computational Effort: An Adaptive Accuracy-aware Approach Across System Layers
Creators: name: Bromberger, Michael
Publisher: name: Karlsruhe
Year: 2018
Subjects: Approximate Computing
Accuracy-aware Computing
System Tuning
Energy efficiency

description: This thesis introduces a novel methodology to realize accuracy-aware systems, which will help designers integrate accuracy awareness into their systems. It proposes an adaptive accuracy-aware approach across system layers that addresses current challenges in that domain, combining and tuning accuracy-aware methods on different system layers. To widen the scope of accuracy-aware computing including approximate computing for other domains, this thesis presents innovative accuracy-aware methods and techniques for different system layers.
The required tuning of the accuracy-aware methods is integrated into a configuration layer that tunes the available knobs of the accuracy-aware methods integrated into a system.
Tenthredopsis Costa 1859
Creators: name: Lee, Jong-Wook
name: Park, Jin-Kyung Choi and Bia
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Tenthredinidae
Tenthredopsis

description: Genus Tenthredopsis Costa, 1859 ẙNjDzḇṩ
 Tenthredopsis Costa, 1859: 98. Type species: Tenthredo tessellata Klug, 1817.
 Ebolia Costa, 1859: 105. Type species: Ebolia floricola Costa, 1859.
 Thomsonia Konow, 1884a: 327. Type species: Perineura thomsonia Konow, 1884.
 Eutenthredopsis Enslin, 1913: 99. Type species: Tenthredo litterata Geoffroy, 1785.
description: Published as part of Lee, Jong-Wook & Park, Jin-Kyung Choi and Bia, 2019, Synoptic list of Symphyta (Hymenoptera) in Korea, pp. 1-96 in Journal of Species Research 8 (1) on page 69, DOI: 10.12651/JSR.2019.8.1.001, http://zenodo.org/record/13137712
Additional file 1 of Plasmodium falciparum genetic diversity and multiplicity of infection based on msp-1, msp-2, glurp and microsatellite genetic markers in sub-Saharan Africa: a systematic review and meta-analysis
Creators: name: Mwesigwa, Alex
name: Ocan, Moses
name: Musinguzi, Benson
name: Nante, Rachel Wangi
name: Nankabirwa, Joaniter I.
name: Kiwuwa, Steven M.
name: Kinengyere, Alison Annet
name: Castelnuovo, Barbara
name: Karamagi, Charles
name: Obuku, Ekwaro A.
name: Nsobya, Samuel L.
name: Mbulaiteye, Sam M.
name: Byakika-Kibwika, Pauline
Publisher: name: figshare
Year: 2024
Subjects: subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1. Search strategy.
Impact of transcutaneous auricular vagus nerve stimulation on postoperative pain in patients undergoing perianal surgery: a randomized trial
Creators: name: Yin, Zhi-Yu
name: Wang, Jing
name: Wei, Pan
name: Gao, Hao
name: Sun, Long
name: Song, Jian-Gang
name: Tang, Wei
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy
subject: Mental Health

description: This study aims to evaluate the effectiveness of transcutaneous auricular vagus nerve stimulation (taVNS) on postoperative pain in patients following perianal surgery. 96 patients were randomly assigned to either the taVNS group or the sham stimulation group. Patients received stimulation once 30 min before the operation and once more 24 h after the operation, with each session lasting 30 min. The VAS scores were recorded at 2, 6, 24, 48, and 72 h, as well as 7 days postoperatively. Data were collected on the first change of dressing, the first defecation, the frequency of supplementary analgesia, and the occurrence of adverse reactions. Patient satisfaction was assessed at the time of hospital discharge. The VAS scores of patients in the taVNS group were significantly lower than those in the sham stimulation group at 2, 6, 24, 48, and 72 h postoperatively, at the time of the first dressing change, and at the time of the first defecation (p < 0.05). The rate of postoperative supplementary analgesic use was significantly higher in the sham stimulation group compared to the taVNS group (p < 0.05). The incidence of urinary retention was lower in the taVNS group (p < 0.05). No adverse reactions like hypotension or bradycardia were observed in either group. Patient satisfaction was higher in the taVNS group (p < 0.05). taVNS effectively alleviates postoperative pain in patients undergoing perianal surgery without increasing the risk of complications.
การเปรียบเทียบวิธีวิเคราะห์ข้อมูลคุณภาพอากาศ: กรณีศึกษาพลังงานทางเลือกก๊าซชีวภาพในจังหวัดสุพรรณบุรี
Creators: name: พิมพ์พรรณ อำพันธ์ทอง
Publisher: name: สถาบันวิจัยและพัฒนา มหาวิทยาลัยเทคโนโลยีราชมงคลธัญบุรี
Year: 2022
Subjects: วิธีบ็อกซ์-เจนกินส์
การพยากรณ์
ก๊าซชีวภาพ
คุณภาพอากาศ

description: Journal of Applied Research on Science and Technology (JARST), 21, 1, 44-54
Additional file 3 of Plasmodium falciparum genetic diversity and multiplicity of infection based on msp-1, msp-2, glurp and microsatellite genetic markers in sub-Saharan Africa: a systematic review and meta-analysis
Creators: name: Mwesigwa, Alex
name: Ocan, Moses
name: Musinguzi, Benson
name: Nante, Rachel Wangi
name: Nankabirwa, Joaniter I.
name: Kiwuwa, Steven M.
name: Kinengyere, Alison Annet
name: Castelnuovo, Barbara
name: Karamagi, Charles
name: Obuku, Ekwaro A.
name: Nsobya, Samuel L.
name: Mbulaiteye, Sam M.
name: Byakika-Kibwika, Pauline
Publisher: name: figshare
Year: 2024
Subjects: subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 3. Subgroup and Heterogeneity analysis.
Development of color learning protocol based on music-color association for people with visual impairment
Creators: name: Park, Hye Young
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: This research developed and confirmed the feasibility of a color-learning mobile application for people with visual impairment based on the hypothesis that the music-color association may be synaesthetically induced through emotion. In total, 120 participants with visual impairment, comprising 60 congenital and 60 adventitious cases, were recruited. They underwent sequential procedures: Procedure 1 involved selecting color-music associations and designing tasks; Procedure 2 focused on application development with accessibility features; and Procedure 3 verified usability and effectiveness. Significant improvements were observed in hue, luminance, and saturation scores following the use of the music-color association application among participants with both congenital and adventitious visual impairment. The effectiveness of the application in facilitating color learning is evident, suggesting its potential utility in enhancing color perception in this population. This research introduces a novel framework for color learning among visually impaired individuals using a music-based synesthetic approach. The developed mobile application offers a promising avenue for efficiently improving color perception and learning, thereby addressing the critical need for accessibility and education for this population. Further research should explore the long-term effects and broader applications of synesthetic-induced learning in diverse contexts.
Tenthredopsis carinata subsp. carinata Malaise 1931
Creators: name: Lee, Jong-Wook
name: Park, Jin-Kyung Choi and Bia
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Tenthredinidae
Tenthredopsis
Tenthredopsis carinata
Tenthredopsis carinata carinata malaise, 1931

description: 401. Tenthredopsis carinata carinata Malaise, 1931
 ûȓẙNjDzḇ
 Tenthredopsis carinatus [sic!] Malaise, 1931a: 9-10.
 Korean records. Lee and Ryu, 1996a; Lee et al., 2000; Paek et al., 2010; Lyu et al., 2014.
 Host plant. Unknown.
 Distribution. Korea (South), China, Japan, Latvia, Russia.
description: Published as part of Lee, Jong-Wook & Park, Jin-Kyung Choi and Bia, 2019, Synoptic list of Symphyta (Hymenoptera) in Korea, pp. 1-96 in Journal of Species Research 8 (1) on page 69, DOI: 10.12651/JSR.2019.8.1.001, http://zenodo.org/record/13137712
Additional file 4 of Plasmodium falciparum genetic diversity and multiplicity of infection based on msp-1, msp-2, glurp and microsatellite genetic markers in sub-Saharan Africa: a systematic review and meta-analysis
Creators: name: Mwesigwa, Alex
name: Ocan, Moses
name: Musinguzi, Benson
name: Nante, Rachel Wangi
name: Nankabirwa, Joaniter I.
name: Kiwuwa, Steven M.
name: Kinengyere, Alison Annet
name: Castelnuovo, Barbara
name: Karamagi, Charles
name: Obuku, Ekwaro A.
name: Nsobya, Samuel L.
name: Mbulaiteye, Sam M.
name: Byakika-Kibwika, Pauline
Publisher: name: figshare
Year: 2024
Subjects: subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 4. RoB assessment.
Reversed dynamics to uncover basins of attraction of asynchronous logical models
Creators: name: Fueyo, Sébastien
name: Monteiro, Pedro T.
name: Naldi, Aurélien
name: Dorier, Julien
name: Remy, Elisabeth
name: Chaouiya, Claudine
Publisher: name: F1000Research
Year: 2017

description: Logical models permit to assess most salient dynamical properties of large regulatory and signalling networks. Of particular relevance are model attractors that are often associated to cellular phenotypes. While methods have been proposed to identify these attractors, the question of their basins of attraction has not been much considered. Non deterministic, asynchronous dynamics are rather intricate, and distinct attractors may be reachable from the same states, while irreversible commitments are made in some other states.

Considering an asynchronous setting, for any Boolean model, we define the reverse model whose dynamics is the reversed dynamics of the original model. It is then clear that exploring this reverse dynamics provides the reachable states from each attractor, i.e., its (weak) basin of attraction. We are then able to compute the strong basin of an attractor, which encompasses the states that lead only to that attractor, as well as the set of states that are entry points for this basin. Our method is illustrated on the basins of attraction of a published model of cell fate decision upon activation of death receptors. Finally, we discuss the implications of the (a)synchronous updating scheme.
Probing the interaction behavior of Nano-Resveratrol with α-lactalbumin in the presence of β-lactoglobulin and β-casein: spectroscopy and molecular simulation studies
Creators: name: Ghadamgahi, Zahra
name: Motavalizadehkakhky, Alireza
name: Mehrzad, Jamshid
name: Amiri-Tehranizadeh, Zeinab
name: Chamani, Jamshidkhan
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biophysics
Biochemistry
Physical Sciences not elsewhere classified
Molecular Biology
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Cancer

description: The main purpose of this research was to evaluate the role of α-lactalbumin (α-LA), β-lactoglobulin (β-LG), and β-Caseins (β-CN) in the binding interaction between Nano Resveratrol (Nano Res), as binary and ternary systems. This investigation was fulfilled through the application of multi-spectroscopic, transmission electron microscopy (TEM), field emission scanning electron microscope (FE-SEM), conductometry, isothermal titration calorimetry (ITC), and molecular dynamics (MD) simulation techniques. Fluorescence spectroscopy observations illustrated the effectiveness of Nano Res throughout the quenching of α-LA, (α-LA-β-LG), and (α-LA-β-CN) complexes, confirming the occurrence of interaction through the combination of static and dynamic mechanisms. An enhancement in the temperature of all three complexes caused a decrease in their Ksv and Kb values, which indicates the static and dynamic behavior of their interactions. The obtained thermodynamic parameters proved the dominance of electrostatic interaction as the binding force of both binary and ternary systems. The observed properties of Tyr or Trp residues in proteins through the data of synchronous spectroscopy at Δλ = 15 and 60 nm, respectively, demonstrated the closer positioning of (α-LA-β-CN) complex to the proximity of Trp residues when compared to the two other cases. According to the resonance light scattering (RLS) measurements, the detection of a much greater RLS intensity in (α-LA-β-CN) Nano Res complex suggested the production of a larger complex. Furthermore, the conductometry outcomes displayed an increase in molar conductivity and therefore approved the occurrence of interaction between Nano Res and proteins in both binary and ternary systems. The spherical shape of Nano Res was confirmed through the results of FE-SEM and TEM analyses. The conformational changes of proteins throughout the binding of Nano Res was evaluated by circular dichroism (CD) technique, while molecular docking and MD simulations affirmed the binding of Nano Res to α-LA, (α-LA-β-LG), and (α-LA-β-CN) complexes as binary and ternary systems. These In Silico study data confirm the results of in vitro assessments. The occurrence of changes in the secondary structure of β-galactosidase was implied through the increased enzyme catalytic activity induced by the interaction of different lactose concentrations.