cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Data-Driven Convex Approach to Off-road Navigation via Linear Transfer Operators
Creators: name: Moyalan, Joseph
name: Chen, Yongxin
name: Vaidya, Umesh
Publisher: name: arXiv
Year: 2022
Subjects: subject: Systems and Control (eess.SY)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: We consider the problem of optimal navigation control design for navigation on off-road terrain. We use traversability measure to characterize the degree of difficulty of navigation on the off-road terrain. The traversability measure captures the property of terrain essential for navigation, such as elevation map, terrain roughness, slope, and terrain texture. The terrain with the presence or absence of obstacles becomes a particular case of the proposed traversability measure. We provide a convex formulation to the off-road navigation problem by lifting the problem to the density space using the linear Perron-Frobenius (P-F) operator. The convex formulation leads to an infinite-dimensional optimal navigation problem for control synthesis. The finite-dimensional approximation of the infinite-dimensional convex problem is constructed using data. We use a computational framework involving the Koopman operator and the duality between the Koopman and P-F operator for the data-driven approximation. This makes our proposed approach data-driven and can be applied in cases where an explicit system model is unavailable. Finally, we demonstrate the application of the developed framework for the navigation of vehicle dynamics with Dubin's car model.
Interference and Bandwidth Adjusted (ETX) in Wireless Multi-hop Networks
Creators: name: Javaid, Nadeem
name: Bibi, Ayesha
name: Djouani, Karim
Publisher: name: arXiv
Year: 2010
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: In this paper, we propose a new quality link metric, interference and bandwidth adjusted ETX (IBETX) for wireless multi-hop networks. As MAC layer affects the link performance and consequently the route quality, the metric therefore, tackles the issue by achieving twofold MAC-awareness. Firstly, interference is calculated using cross-layered approach by sending probes to MAC layer. Secondly, the nominal bit rate information is provided to all nodes in the same contention domain by considering the bandwidth sharing mechanism of 802.11. Like ETX, our metric also calculates link delivery ratios that directly affect throughput and selects those routes that bypass dense regions in the network. Simulation results by NS-2 show that IBETX gives 19% higher throughput than ETX and 10% higher than Expected Throughput (ETP). Our metric also succeeds to reduce average end-to-end delay up to 16% less than Expected Link Performance (ELP) and 24% less than ETX.
Exploiting the rationale behind substrate recognition by promiscuous thermophilic NDP-sugar pyrophosphorylase for expanding glycorandomization: an in silico study
Creators: name: Gogoi, Prerana
name: Mordina, Prerana
name: Kanaujia, Shankar Prasad
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: The fundamental substrates for protein glycosylation are provided by a group of enzymes known as NDP-sugar pyrophosphorylases (NSPases) which utilize nucleotide triphosphate (NTP) and sugar 1-phosphate to catalyze the formation of nucleotide diphospho-sugar (NDP-sugar). The promiscuous nature of NSPases is often exploited during chemoenzymatic glycorandomization in the pursuit of novel therapeutics. However, till date, the number of inherently promiscuous NSPases reported and the rationale behind their promiscuity is meager. In this study, we have identified a set of NSPases from a hyperthermophilic archaeon Pyrococcus horikoshii OT3 to identify probable candidates for glycorandomization. We identified a set of NSPases that include both substrate-specific and substrate-promiscuous NSPases with a visible predominance of the latter group. The rationale behind the promiscuity (or specificity) vividly lies in the repertoire of amino acid residues that assemble the active site for recognition of the substrate moiety. Furthermore, the absence of a function-specific auxiliary domain promotes substrate promiscuity in NSPases. This study, thus, provides a novel set of thermophilic NSPases that can be employed for chemoenzymatic glycorandomization. More importantly, identification of the residues that render substrate promiscuity (or specificity) would assist in sequence-based rational engineering of NSPases for enhanced glycorandomization. Communicated by Ramaswamy H. Sarma
Course-Prerequisite Networks for Analyzing and Understanding Academic Curricula
Creators: name: Stavrinides, Pavlos
name: Zuev, Konstantin
Publisher: name: arXiv
Year: 2022
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Social and Information Networks (cs.SI)
subject: Applications (stat.AP)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Understanding a complex system of relationships between courses is of great importance for the university's educational mission. This paper is dedicated to the study of course-prerequisite networks (CPNs), where nodes represent courses and directed links represent the formal prerequisite relationships between them. The main goal of CPNs is to model interactions between courses, represent the flow of knowledge in academic curricula, and serve as a key tool for visualizing, analyzing, and optimizing complex curricula. First, we consider several classical centrality measures, discuss their meaning in the context of CPNs, and use them for the identification of important courses. Next, we describe the hierarchical structure of a CPN using the topological stratification of the network. Finally, we perform the interdependence analysis, which allows to quantify the strength of knowledge flow between university divisions and helps to identify the most intradependent, influential, and interdisciplinary areas of study. We discuss how course-prerequisite networks can be used by students, faculty, and administrators for detecting important courses, improving existing and creating new courses, navigating complex curricula, allocating teaching resources, increasing interdisciplinary interactions between departments, revamping curricula, and enhancing the overall students' learning experience. The proposed methodology can be used for the analysis of any CPN, and it is illustrated with a network of courses taught at the California Institute of Technology. The network data analyzed in this paper is publicly available in the GitHub repository.
description: 25 pages, 20 figures, 10 Tables
Boosting Asymmetric Charged DM via Thermalization
Creators: name: Geller, Michael
name: Heller-Algazi, Zamir
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We consider a dark sector scenario with two dark matter species with opposite dark $U(1)$ charges and an asymmetric population comprising some fraction of the dark matter abundance. A new mechanism for boosting dark matter is introduced, arising from the large mass hierarchy between the two particles. In the galaxy, the two species thermalize efficiently through dark Rutherford scattering greatly boosting the lighter dark matter particle, far above the virial and escape velocities in the galaxy, while the dark charge prevents it from escaping. We study the consequences of this scenario for direct-detection experiments, assuming a kinetic mixing between the dark photon and the photon. If the charged dark sector makes up 5% of the total DM mass in our galaxy and the mass ratio is between $10^3-10^4$, we find that current and future experiments may probe the boosted light dark matter for masses down to 100 keV, in a hitherto unexplored parameter range.
description: 26 pages, 8 figures
Identity Representations of Turkey and Europe in Foreign Media: Regional and Global Perspectives on EU-Turkey Relations
Creators: name: Louis, Justine
name: Magued, Shaimaa
name: Mzhavanadze, Nino
Publisher: name: Zenodo
Year: 2018
Subjects: European Union; Turkey; EU-Turkey Relations; Identity Politics; Identity Representation; Foreign Media; Regional and Global Perspectives; Culture; Critical Discourse Analysis; Significant Other; Georgia; Egypt; US; Russia; Newspaper; Conflict

description: FEUTURE Online Paper No. 14

This FEUTURE paper examines global (Russian and US press) and regional (Egyptian and Georgian press) perspectives on EU-Turkey relations since 1999 with respect to identity and culture. Using the Critical Discourse Analysis methodology, the research traces the evolution of Turkey and Europe’s identity representations in foreign media, therefore providing an outlook of the way significant Others make sense of the EU-Turkey relationship in the context of Turkey’s EU bid. While the more dynamic (and positive) Egyptian and American press coverage initially contrasted with Georgian and Russian newspapers’ static portrayal of Europe and Turkey’s respective identities as antithetical, the prominence of certain identity markers in recent drivers contributed to shifts in identity representations supporting the degradation of EU-Turkey relations toward conflict.
description: This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 692976. This publication reflects the views only of the authors, and the Commission cannot be held responsible for any use which may be made of the information contained therein.
Causality in classical electrodynamics
Creators: name: Savage, C. M.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Physics Education (physics.ed-ph)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences

description: Causality in electrodynamics is a subject of some confusion, especially regarding the application of Faraday's law and the Ampere-Maxwell law. This has led to the suggestion that we should not teach students that electric and magnetic fields can cause each other, but rather focus on charges and currents as the causal agents. In this paper I argue that fields have equal status as casual agents, and that we should teach this. Following a discussion of causality in classical physics I will use a numerical solution of Maxwell's equations to inform a field based causal explanation in electrodynamics.
description: Comments welcome
Identification of the naphthoquinone derivative inhibitors binding site in heat shock protein 90: an induced-fit docking, molecular dynamics and 3D-QSAR study
Creators: name: Godoy-Castillo, Claudio
name: Bravo-Acuña, Nicolas
name: Arriagada, Gloria
name: Faunes, Fernando
name: León, Roberto
name: Soto-Delgado, Jorge
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: The combination of molecular modeling methods to identify the putative binding site of inhibitors constitutes an important tool in drug discovery. In this work, we used these analyses to understand the potent inhibitory effect of naphthoquinone derivatives on heat shock protein 90 (Hsp90), one of the proteins involved in many types of cancer. Molecular docking results indicated that some favorable interactions of key amino acid residues at the binding site of Hsp90 with these quinones would be responsible for the inhibition of Hsp90 activity. Molecular docking and molecular dynamics simulation were carried out to further understand the binding modes and the interactions between the protein and these inhibitors. The main residues of the internal cavity were Val136, Phe138, Tyr139, Val150, Trp162 and Val186. The high concordance between the docking results and 3D-QSAR contour maps gives us helpful information about the environment of the binding site. Our results provide the bases for a rational modification of new molecules based in quinone scaffold, in order to design more potent Hsp90 inhibitors, which would exhibit highly potent antitumor activity. Communicated by Ramaswamy H. Sarma
Three-dimensional molecular line transfer: A simulated star-forming region
Creators: name: Rundle, David
name: Harries, Tim J.
name: Acreman, David M.
name: Bate, Matthew R.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present the first non-LTE, co-moving frame molecular line calculations of a star-forming cluster simulated using smoothed particle hydrodynamics (SPH), from which we derive high-resolution synthetic observations. We have resampled a particle representation onto an adaptive mesh and self-consistently solved the equations of statistical equilibrium in the co-moving frame, using TORUS, a three-dimensional adaptive mesh refined (AMR) radiative transfer (RT) code. We verified the applicability of the code to the conditions of the SPH simulation by testing its output against other codes. We find that the level populations obtained for optically thick and thin scenarios closely match the ensemble average of the other codes. We have used the code to obtain non-LTE level populations of multiple molecular species throughout the cluster and have created three-dimensional velocity-resolved spatial maps of the emergent intensity. Line profiles of cores traced by N2H+ (1-0) are compared to probes of low density gas, 13CO (1-0) and C18O (1-0), surrounding the cores along the line of sight. The relative differences of the line-centre velocities are shown to be small compared to the velocity dispersion, matching recent observations. We conclude that one cannot reject competitive accretion as a viable theory of star formation based on observed velocity profiles.
description: 19 pages, 17 figures, 3 tables
31814: Lockdown for newcomers to Oxford
Creators: name: Project, Lockdown2020 and Beyond
Publisher: name: University of Oxford
Year: 2023
Subjects: classificationCode: 479999
subject: Other language, communication and culture not elsewhere classified

description: My husband and I have recently moved from Australia to the UK and are both working at the University from home. When social isolation began, we set up a small workstation at home when he could no longer go to his lab. Since then I have begun working as well... and squeezed my workstation into the space too. Our mornings have mainly stayed the same. Instead of brewing supermarket coffee, we pay to have our friends deliver their roasted beans directly to our flat. While it's nice to have beautiful coffee at home for a change, we spend a lot of time worrying about loved ones back home who run small businesses in hospitality and events.During the weekdays, since it's just us, we listen to music while working unless one of us is in a meeting. That's pretty standard since we've worked remotely before, and have been living and socialised online since a young age. But it's really odd to be both working remotely the University at the same time, since it's only 10 minutes away. While the majority of my colleagues live quite locally, a portion of my husband's young team left Oxford to be with their families overseas or in London. They also cannot run most of their usual experiments at the moment. We both notice it's harder than it would have been to gauge how people at work are coping with social isolation, and lots of conscious effort goes into checking in and asking how people are. In the evenings and on the weekend we usually would have met with our new friends at a restaurant or pub. Instead, we've been playing online games with everyone. Having older family members join Zoom meetings at the same time from across the world is new... we don't think they would have coordinated digitally like that before unless it was a special occasion. As newcomers to the UK, it was a historical highlight to get a letter from the Prime Minister Borris Johnson telling us to stay home. Luckily for us, we're situated very near woodland trails and parks and can walk there for exercise. It's been magical to witness our first English spring as it happens.
pMSSM Dark Matter Searches on Ice
Creators: name: Cotta, R. C.
name: Howe, K. T. K.
name: Hewett, J. L.
name: Rizzo, T. G.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We explore the capability of the IceCube/Deepcore array to discover signal neutrinos resulting from the annihilations of Supersymmetric WIMPS that may be captured in the solar core. In this analysis, we use a previously generated set of /sim 70k model points in the 19-dimensional parameter space of the pMSSM which satisfy existing experimental and theoretical constraints. Our calculations employ a realistic estimate of the IceCube/DeepCore effective area that has been modeled by the IceCube collaboration. We find that a large fraction of the pMSSM models are shown to have significant signal rates in the anticipated IceCube/DeepCore 1825 day dataset, including some prospects for an early discovery. Many models where the LSP only constitutes a small fraction of the total dark matter relic density are found to have observable rates. We investigate in detail the dependence of the signal neutrino fluxes on the LSP mass, weak eigenstate composition, annihilation products and thermal relic density, as well as on the spin-independent and spin-dependent scattering cross sections. Lastly, We compare the model coverage of IceCube/DeepCore to that obtainable in near-future direct detection experiments and to pMSSM searches at the 7 TeV LHC.
description: 37 pages, 17 figures
In-Silico approach for identification of effective and stable inhibitors for COVID-19 main protease (Mpro) from flavonoid based phytochemical constituents of Calendula officinalis
Creators: name: Das, Pratik
name: Majumder, Ranabir
name: Mandal, Mahitosh
name: Basak, Piyali
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Computational Biology

description: The recent outbreak of the coronavirus disease COVID-19 is putting the world towards a great threat. A recent study revealed COVID-19 main protease (Mpro) is responsible for the proteolytic mutation of this virus and is essential for its life cycle. Thus inhibition of this protease will eventually lead to the destruction of this virus. In-Silico Molecular docking was performed with the Native ligand and the 15 flavonoid based phytochemicals of Calendula officinals to check their binding affinity towards the COVID-19 main protease. Finally, the top 3 compounds with the highest affinity have been chosen for molecular dynamics simulation to analyses their dynamic properties and conformational flexibility or stability. In-Silico Docking showed that major phytochemicals of Calendula officinals i.e. rutin, isorhamnetin-3-O-β-D, calendoflaside, narcissin, calendulaglycoside B, calenduloside, calendoflavoside have better binding energy than the native ligand (inhibitor N3). MD simulation of 100 ns revealed that all the protease-ligand docked complexes are overall stable as compare to Mpro-native ligand (inhibitor N3) complex. Overall, rutin and caledoflaside showed better stability, compactness, and flexibility. Our in silico (Virtual molecular docking and Molecular dynamics simulation) studies pointed out that flavonoid based phytochemicals of calendula (rutin, isorhamnetin-3-O-β-D, calendoflaside) may be highly effective for inhibiting Mpro which is the main protease for SARS-CoV-2 causing the deadly disease COVID-19. Rutin is already used as a drug and the other two compounds can be made available for future use. Thus the study points a way to combat COVID-19 by the use of major flavonoid based phytochemicals of Calendula officinals. Communicated by Ramaswamy H. Sarma
Investigation of the magnetic field effects on the electron mobility in tri-(8-hydroxyquinoline)-aluminum based light-emitting devices
Creators: name: Peng, Qiming
name: Sun, Jixiang
name: Li, Xianjie
name: Li, Mingliang
name: Li, Feng
Publisher: name: arXiv
Year: 2011
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We investigated the mganetic field effects (MFEs) on electron mobility in tri-(8-hydroxyquinoline)-aluminum based light-emitting devices by transient-electroluminescence method upon application of various offset voltages. It is found the rising edges of EL pulses are well overlapped and the falling edges of EL pulses are separated for the magnetic field on and off when Voffset=0 V and Voffset>Vturnon of the devices. The results suggest the bipolaron model and the triplet-polaron interaction model related to the carriers mobilities are not the dominant mechanisms to explain the MFEs under our experimental conditions, and the magnetic field affects the carriers recombination process is confirmed.
description: 14 pages, 4 figures
31820: Abandoned Oxford
Creators: name: Project, Lockdown2020 and Beyond
Publisher: name: University of Oxford
Year: 2023
Subjects: classificationCode: 479999
subject: Other language, communication and culture not elsewhere classified

description: A cycle ride is often the way I choose to take my daily exercise and the centre of Oxford has taken on an air of tranquillity and desertion. The lack of cars, students and tourists makes it nearly unrecognisable in comparison with my pre-lockdown daily commute, also on bike. Improved air quality is noticeable and I have found the tow paths and parks now busier so bizarrely a trip into town brings me into contact with fewer people.
Infrared effects in inflationary correlation functions
Creators: name: Seery, David
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this article, I briefly review the status of infrared effects which occur when using inflationary models to calculate initial conditions for a subsequent hot, dense plasma phase. Three types of divergence have been identified in the literature: secular, "time-dependent" logarithms, which grow with time spent outside the horizon; "box-cutoff" logarithms, which encode a dependence on the infrared cutoff when calculating in a finite-sized box; and "quantum" logarithms, which depend on the ratio of a scale characterizing new physics to the scale of whatever process is under consideration, and whose interpretation is the same as conventional field theory. I review the calculations in which these divergences appear, and discuss the methods which have been developed to deal with them.
description: Invited review for focus section of Classical & Quantum Gravity on nonlinear and nongaussian perturbation theory. Some improvements compared to version which will appear in CQG, especially in Sec. 2.3. 30 pages + references.
Ο Σερβικός Στρατός στην Κέρκυρα κατά τον Α΄ΠΠ: πτυχές ελληνοσερβικών σχέσεων 1916-1918
Creators: name: Πέτσος, Θεόδωρος Χρήστου
Publisher: name: Aristotle University of Thessaloniki
Year: 2024
Subjects: Σερβικός στρατός
Κέρκυρα
Αλβανικός Γολγοθάς
Serbian Army
Corfu
Albanian Golgotha

description: Σκοπός της διατριβής ήταν η μελέτη των συνθηκών υπό της οποίες ο Σερβικός Στρατός υποχώρησε από τη Σερβία κατά τη διάρκεια του Α’ Παγκοσμίου Πολέμου πιεζόμενος από τις εχθρικές δυνάμεις. Παρουσιαστήκαν οι διαμορφωθείσες συνθήκες, περιγράφονται τα διλλήματα και οι αποφάσεις της σερβικής ηγεσίας οι οποίες εν τέλει οδήγησαν τον Σερβικό Στρατό στην έξοδο από την χώρα του και αναζήτηση καταφυγίου στο νησί της Κέρκυρας, η γενικότερη διαμονή των Σέρβων και οι προσπάθειες για την ανασύνταξη του Σερβικού Στρατού .Στη συνέχεια παρουσιάστηκε η επιχείρηση μεταφοράς των Σέρβων στο Μέτωπο της Θεσσαλονίκης όπου έλαβαν μέρος σε πολεμικές επιχειρήσεις στο πλευρό των δυνάμεων της ΑΝΤΑΝΤ. Δόθηκε ιδιαίτερη έμφαση στο ρόλο που διαδραμάτισαν οι δυο πολιτικοί ηγέτες Ελλάδος και Σερβίας, Ελευθέριος Βενιζέλος και Νίκολα Πάσιτς στην προσπάθεια διάσωσης του σερβικού στρατού αλλά και στη διατήρηση των φιλικών σχέσεων μεταξύ των δυο λαών . δίδεται η μεγαλύτερη έμφαση καθώς το γεγονός της παραμονής του Σερβικού Στρατού στην Κέρκυρα και ανάδειξη πτυχών και δραστηριοτήτων των Σέρβων, αποτελούν τον βασικό στόχο της μεταπτυχιακής διατριβής. Περιγράφονται οι συνθήκες παραμονής του Σερβικού Στρατού στην Κέρκυρα, η ανταπόκριση των ντόπιων κατοίκων, αλλά και η συνύπαρξη με τους Σέρβους ενώ δίδεται γενική και ειδική εικόνα των Σέρβων στρατιωτών στο ξένο έδαφος όσον αφορά την εν γένει στάση των Σέρβων, αλλά και για την ανάπτυξη δραστηριοτήτων. Επίσης, περιγράφεται η θρησκευτική ζωή των Σέρβων στην Κέρκυρα και τα μνημεία που αναγέρθηκαν τα οποία θυμίζουν τη σερβική παρουσία στο νησί.
description: Τhe purpose of the thesis was to study the conditions under which the Serbian Army retreated from Serbia during World War I under pressure from enemy forces. The conditions that led to a retreat to the island of Corfu were presented, the general residence of the Serbs and the efforts for the regrouping of the Serbian Army. Then the operation of transporting the Serbs to the Front of Thessaloniki where they took part in war events was presented on the side of the Entente forces. Particular emphasis was placed on the role played by the two political leaders of Greece and Serbia, Eleftherios Venizelos and Nikola Pašić, in the effort to save the Serbian army and in maintaining friendly relations between the two nations .
Elastic buildings: Calibrated district-scale simulation of occupant-flexible campus operation for hybrid work optimization
Creators: name: Mosteiro-Romero, Martín
name: Miller, Clayton
name: Chong, Adrian
name: Stouffs, Rudi
Publisher: name: arXiv
Year: 2022
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Multiagent Systems (cs.MA)
subject: Systems and Control (eess.SY)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Before 2020, the way occupants utilized the built environment had been changing slowly towards scenarios in which occupants have more choice and flexibility in where and how they work. The global COVID-19 pandemic accelerated this phenomenon rapidly through lockdowns and hybrid work arrangements. Many occupants and employers are considering keeping some of these flexibility-based strategies due to their benefits and cost impacts. This paper simulates various scenarios related to the operational technologies and policies of a real-world campus using a district-scale City Energy Analyst (CEA) model that is calibrated with measured energy and occupancy profiles extracted from WiFi data. These scenarios demonstrate the energy impact of ramping building operations up and down more rapidly and effectively to the flex-based work strategies that may solidify. The scenarios show a 4-12% decrease in space cooling demand due to occupant absenteeism if centralized building system operation is in place, but as high as 21-68% if occupancy-driven building controls are implemented. The paper discusses technologies and strategies that are important in this paradigm shift of operations.
description: Building and Environment post-print
Tracing the Peculiar Dark Matter Structure in the Galaxy Cluster CL 0024+17 with Intracluster Stars and Gas
Creators: name: Jee, M. J.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: ICL is believed to originate from the stars stripped from cluster galaxies. They are no longer gravitationally bound to individual galaxies, but to the cluster, and their smooth distribution potentially makes them serve as much denser tracers of the cluster dark matter than the sparsely distributed cluster galaxies. We present our study of the ICL in Cl 0024+17 using both ACS and Subaru data, where we previously reported discovery of a ringlike dark matter structure with gravitational lensing. The ACS images provide much lower sky levels than ground data, and enable us to measure relative variation of surface brightness reliably. This analysis is repeated with the Subaru images to examine if consistent features are recovered despite different reduction scheme and instrumental characteristics. We find that the ICL profile clearly resembles the peculiar mass profile, which stops decreasing at r~50" (~265 kpc) and slowly increases until it turns over at r~75" (~397 kpc). This feature is seen in both ACS and Subaru images for nearly all available passband images while the features are stronger in red filters. The consistency across different filters and instruments strongly rules out the possibility that the feature might come from any residual, uncorrected calibration errors. In addition, our re-analysis of the cluster X-ray data shows that the peculiar mass structure is also indicated by a non-negligible bump in the intracluster gas profile when the geometric center of the dark matter ring, not the peak of the X-ray emission, is chosen as the center of the radial bin. The location of the gas ring is closer to the center by ~15" (~80 kpc), raising an interesting possibility that the ring-like structure is expanding and the gas ring is lagging behind perhaps because of the ram pressure if both features in mass and gas share the same dynamical origin.
description: Accepted to ApJ for publication
The Coming of Age of Nucleic Acid Vaccines during COVID-19
Creators: name: Rando, Halie M.
name: Lordan, Ronan
name: Kolla, Likhitha
name: Sell, Elizabeth
name: Lee, Alexandra J.
name: Wellhausen, Nils
name: Naik, Amruta
name: Kamil, Jeremy P.
name: Consortium, COVID-19 Review
name: Gitter, Anthony
name: Greene, Casey S.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Biomolecules (q-bio.BM)
subject: FOS: Biological sciences

description: In the 21st century, several emergent viruses have posed a global threat. Each pathogen has emphasized the value of rapid and scalable vaccine development programs. The ongoing SARS-CoV-2 pandemic has made the importance of such efforts especially clear. New biotechnological advances in vaccinology allow for recent advances that provide only the nucleic acid building blocks of an antigen, eliminating many safety concerns. During the COVID-19 pandemic, these DNA and RNA vaccines have facilitated the development and deployment of vaccines at an unprecedented pace. This success was attributable at least in part to broader shifts in scientific research relative to prior epidemics; the genome of SARS-CoV-2 was available as early as January 2020, facilitating global efforts in the development of DNA and RNA vaccines within two weeks of the international community becoming aware of the new viral threat. Additionally, these technologies that were previously only theoretical are not only safe but also highly efficacious. Although historically a slow process, the rapid development of vaccines during the COVID-19 crisis reveals a major shift in vaccine technologies. Here, we provide historical context for the emergence of these paradigm-shifting vaccines. We describe several DNA and RNA vaccines and in terms of their efficacy, safety, and approval status. We also discuss patterns in worldwide distribution. The advances made since early 2020 provide an exceptional illustration of how rapidly vaccine development technology has advanced in the last two decades in particular and suggest a new era in vaccines against emerging pathogens.
title: Occupational noise exposures in aquaculture: assessment and mitigation strategy
Creators: name: Stone, Jonathan
Publisher: name: Memorial University of Newfoundland
Year: 2020

description: Noise-induced hearing loss has become an increasing concern for employees in the aquaculture industry. Deafness, hearing loss and hearing impairment have all been identified as some of the most common injury claims from aquaculture labourers. Despite this information, noise levels and associated noise exposures in facilities have been highly undocumented. This research aims to document information on noise exposure in aquaculture and identify short- and long-term solutions to high exposures experienced by employees. Data was collected at four aquaculture facilities in Canada. Noise sources were identified and analyzed in narrowband frequency. Noise exposures were also measured and compared with the recommendations outlined by the Canadian Standards Association. Exposures were observed to be highest during tasks within the vicinity of machinery and other mechanical equipment. Short-term solutions were identified through the selection of appropriate hearing protection. Engineering design solutions were then applied to assess the feasibility of long-term solutions to reduce exposures in facilities. Numerical acoustic simulations were performed on a facility model where the Design of Experiments methodology was applied to validate its acoustical properties. The simulations showed that design solutions could be applied to reduce noise transmission and lower exposure levels throughout the facility.
Anthocyanin derivatives as potent inhibitors of SARS-CoV-2 main protease: An in-silico perspective of therapeutic targets against COVID-19 pandemic
Creators: name: Fakhar, Zeynab
name: Faramarzi, Bahar
name: Pacifico, Severina
name: Faramarzi, Shadab
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: A new pathogen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide and become pandemic with thousands new deaths and infected cases globally. To treat the patients with coronavirus disease (COVID-19), currently no effective drug or vaccine is available. This necessity motivated us to explore potential lead compounds based natural products targeting main protease (Mpro) enzyme of SARS-CoV-2. The Mpro enzyme plays a key role in mediating viral replication and transcription and thus being considered as an attractive drug target. Herein, comprehensive computational investigations were performed to identify new lead compounds against main protease enzyme. In this study, the candidate anthocyanin-derived compounds from PubChem database were filtered considering antiviral characteristics of anthocyanins. The structure-based pharmacophore modeling was developed based on the co-crystallized structure of the enzyme with its biological active inhibitor. The generated hypotheses were applied for virtual screening-based PHASE Screen Score. Docking based virtual screening work flow was used to generate hit compounds using HTVS, SP and XP based Glide Gscore. The obtained hit compounds were filtered using ADMET pharmacological and physicochemical properties screening. Molecular dynamics simulations were performed to explore the binding affinities of the considered compounds. Our study identified six best anthocyanin-derived natural compounds which could be used as promising lead compounds against main protease SARS-CoV-2 virus. Communicated by Ramaswamy H. Sarma
Exact g-function flows from the staircase model
Creators: name: Dorey, Patrick
name: Tateo, Roberto
name: Wilbourne, Ruth
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: Equations are found for exact g-functions corresponding to integrable bulk and boundary flows between successive unitary c<1 minimal conformal field theories in two dimensions, confirming and extending previous perturbative results. These equations are obtained via an embedding of the flows into a boundary version of Al. Zamolodchikov's staircase model.
description: 27 pages, 12 figures
Tunable Vibrational Band Gaps in One-Dimensional Diatomic Granular Crystals with Three-Particle Unit Cells
Creators: name: Boechler, N.
name: Yang, J.
name: Theocharis, G.
name: Kevrekidis, P. G.
name: Daraio, C.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: We investigate the tunable vibration filtering properties of one-dimensional diatomic granular crystals composed of arrays of stainless steel spheres and cylinders interacting via Hertzian contact. The arrays consist of periodically repeated three-particle unit cells (steel-cylinder-sphere) in which the length of the cylinder is varied systematically. We apply static compression to linearize the dynamic response of the crystals and characterize their linear frequency spectrum. We find good agreement between theoretical dispersion relation analysis (for infinite systems), state-space analysis (for finite systems), and experiments. We report the observation of up to three distinct pass bands and two finite band gaps and show their tunability for variations in cylinder length and static compression.
Attribute Inference Attacks in Online Multiplayer Video Games: a Case Study on Dota2
Creators: name: Tricomi, Pier Paolo
name: Facciolo, Lisa
name: Apruzzese, Giovanni
name: Conti, Mauro
Publisher: name: arXiv
Year: 2022
Subjects: subject: Cryptography and Security (cs.CR)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Did you know that over 70 million of Dota2 players have their in-game data freely accessible? What if such data is used in malicious ways? This paper is the first to investigate such a problem. Motivated by the widespread popularity of video games, we propose the first threat model for Attribute Inference Attacks (AIA) in the Dota2 context. We explain how (and why) attackers can exploit the abundant public data in the Dota2 ecosystem to infer private information about its players. Due to lack of concrete evidence on the efficacy of our AIA, we empirically prove and assess their impact in reality. By conducting an extensive survey on $\sim$500 Dota2 players spanning over 26k matches, we verify whether a correlation exists between a player's Dota2 activity and their real-life. Then, after finding such a link ($p$ < 0.01 and $ρ$ > 0.3), we ethically perform diverse AIA. We leverage the capabilities of machine learning to infer real-life attributes of the respondents of our survey by using their publicly available in-game data. Our results show that, by applyingdomain expertise, some AIA can reach up to 98% precision and over 90% accuracy. This paper hence raises the alarm on a subtle, but concrete threat that can potentially affect the entire competitive gaming landscape. We alerted the developers of Dota2.
Mechanisms influencing the polar distribution of cell wall components in seed coat epidermal cells of Arabidopsis
Creators: name: Lee, Yi-Chen
Publisher: name: University of British Columbia
Year: 2020

description: Compositions of plant cell walls are important for morphogenesis and cellular function. Cell wall components are often distributed asymmetrically in the cell wall, but the mechanism for the polar distribution remains unknown. In my research, I used Arabidopsis seed coat epidermal cells as a model system because they deposit large amounts of pectin-rich mucilage in a polar manner to the outer periclinal side of the cell forming a large apoplastic pocket. MUM2 is a β-galactosidase modifying pectin in the mucilage. Using an engineered version of MUM2 fused to a Citrine fluorescent protein (Citrine), distribution pattern of MUM2 in the epidermal cell was determined. MUM2-Citrine is found to preferentially accumulate in the mucilage pocket concomitantly with pectin deposition. The amino acid sequence of MUM2 is not required for the secretion to the pocket. Rather, the polar distribution of MUM2-Citrine is caused by a rearrangement of the secretory pathway that appears to target all secretion to the outer periclinal side of the cell. At the end of mucilage synthesis, the fluorescence of MUM2-Citrine rapidly disappears from the mucilage pocket. The results of western blot analyses shows that the amount of MUM2-Citrine decreases, suggesting that the disappearance of MUM2-Citrine signal is due to protein degradation. Loss-of-function mutations in the genes encoding ASPG1 and RD21A, two proteases that have been detected in mucilage from mature seeds, resulted in a delay of MUM2-Citrine degradation. Also, RD21A, tagged with red fluorescent protein (RFP), accumulated in the vacuole during MUM2 secretion and was translocated to the mucilage pocket at the end of secretion. Taken together, these data suggest that ASPG1 and RD21A are responsible for MUM2 degradation. Mucilage properties were changed in the protease mutants, suggesting that the regulation of distribution of cell wall-modifying enzymes by proteases plays an important role in determining cell wall properties. It has been found that PER36, a peroxidase required for mucilage extrusion, was deposited in a pattern distinct from other mucilage proteins in seed coats. I showed the amino acid sequences of PER36 was required for the unique distribution pattern, suggesting that an unknown distribution mechanism may be involved.
title: Changing ideas about corporate social responsibility CSR and development in Context: The case of Mauritius
Creators: name: Pillay, Renginee G.
Publisher: name: University of Kent
Year: 2022

description: The idea of corporate social responsibility (CSR) has risen to prominence with remarkable rapidity in recent years. Although the literature on contemporary CSR has concentrated almost exclusively on advanced capitalist countries, CSR is increasingly being promoted in a developing country context as an important mechanism for furthering economic and social development goals. Yet, there is currently very limited research about whether contemporary CSR can in fact assist in development. This thesis seeks to contribute to the body of knowledge in this area. The first, theoretical, part of the thesis explores changing ideas about the nature of CSR, and argues that contemporary ideas of CSR are ameliorative in nature, marking a fundamental shift from the original, transformative, idea of the `socially responsible corporation', which emerged in the 1920s and 30s. The thesis also argues that with their emphasis on self-regulation and voluntarism, contemporary ideas about CSR are very much part and parcel of contemporary neo-liberal ideas about economic and social organisation. The second, empirical, part of the thesis seeks to investigate whether the model of CSR being deployed in the developing world is indeed a conservative one and, if so, whether this conservatism is likely to render it ineffectual. It explores how CSR is understood by its practitioners - company executives and other key players - in Mauritius, focusing on the impact of the concept on executive opinion by examining their rhetorical commitment to CSR as well as what that entailed in practice. The research suggests that executives in Mauritius tend to equate CSR with corporate philanthropy, which casts doubt on its ability to make a significant contribution to development. In light of the arguments developed in the thesis, one of its main conclusions is that a return to the earlier, more radical, conception of CSR is needed if CSR is really to make an important contribution to development.
31838: Meeting on-line
Creators: name: Project, Lockdown2020 and Beyond
Publisher: name: University of Oxford
Year: 2023
Subjects: classificationCode: 479999
subject: Other language, communication and culture not elsewhere classified

description: The introduction of Nexus 365 at the university over the last year has meant we're now used to Teams calls, but in nowhere near the quantity we have now. Briefings, project meetings, team catch-ups, one-to-ones and even Knitters United are now all Teams video calls. The normal meeting buzzwords replaced with "can you hear me?" or "I think you're on mute". We play with virtual backgrounds but really enjoy seeing inside other's homes, nosying around home offices, kitchens, dining rooms, lofts and bedrooms. Pets, partners and children make guest appearances. Some people dress for the office, others stay casual. None of us wear shoes, but hopefully everyone wears pants. Then in the evening we do it all again, this time on Zoom with virtual pubs, quizzes and chats with everyone from my octogenarian in-laws to mum's two year old great-great nephew. We celebrate my niece's 21st and my father-in-law's 80th as best we can together, knowing we have a lot of real-life parties to be had when we can be with each other again.
Applications of integral equation theory to biological systems - Electronic supplementary material
Creators: name: Alber, Yannic
Publisher: name: Zenodo
Year: 2022
Subjects: Reference interation site model
3D RISM
Machine learning
Localized free energy
LFE
Free energy derivative
FED

description: Electronic supplementary material of the dissertation with the title "Applications of integral equation theory to biological systems" The dissertation can be found under: http://dx.doi.org/10.17877/DE290R-22534