cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Quality metrics in software engineering
Creators: name: A. Masoud, F.
Publisher: name: University of Liverpool Repository
Year: 2023

description: In the first part of this study software metrics are classified into three categories: primitive, abstract and structured. A comparative and analytical study of metrics from these categories was performed to provide software developers, users and management with a correct and consistent evaluation of a representative sample of the software metrics available in the literature. This analysis and comparison was performed in an attempt to: assist the software developers, users and management in selecting suitable quality metric(s) for their specific software quality requirements and to examine various definitions used to calculate these metrics. In the second part of this study an approach towards attaining software quality is developed. This approach is intended to help all the people concerned with the evaluation of software quality in the earlier stages of software systems development. The approach developed is intended to be uniform, consistent, unambiguous and comprehensive and one which makes the concept of software quality more meaningful and visible. It will help the developers both to understand the concepts of software quality and to apply and control it according to the expectations of users, management, customers etc.. The clear definitions provided for the software quality terms should help to prevent misinterpretation, and the definitions will also serve as a touchstone against which new ideas can be tested.
New Periodic Solutions for Newtonian $n$-Body Problems with Dihedral Group Symmetry and Topological Constraints
Creators: name: Wang, Zhiqiang
name: Zhang, Shiqing
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: In this paper, we prove the existence of a family of new non-collision periodic solutions for the classical Newtonian $n$-body problems. In our assumption, the $n=2l\geq4$ particles are invariant under the dihedral rotation group $D_l$ in $\mathbb{R}^3$ such that, at each instant, the $n$ particles form two twisted $l$-regular polygons. Our approach is variational minimizing method and we show that the minimizers are collision-free by level estimates and local deformations.
The trace reconstruction problem for spider graphs
Creators: name: Sun, Alec
name: Yue, William
Publisher: name: arXiv
Year: 2022
Subjects: subject: Data Structures and Algorithms (cs.DS)
subject: FOS: Computer and information sciences

description: We study the trace reconstruction problem for spider graphs. Let $n$ be the number of nodes of a spider and $d$ be the length of each leg, and suppose that we are given independent traces of the spider from a deletion channel in which each non-root node is deleted with probability $q$. This is a natural generalization of the string trace reconstruction problem in theoretical computer science, which corresponds to the special case where the spider has one leg. In the regime where $d\ge \log_{1/q}(n)$, the problem can be reduced to the vanilla string trace reconstruction problem. We thus study the more interesting regime $d\le \log_{1/q}(n)$, in which entire legs of the spider are deleted with non-negligible probability. We describe an algorithm that reconstructs spiders with high probability using $\exp\left(\mathcal{O}\left(\frac{(nq^d)^{1/3}}{d^{1/3}}(\log n)^{2/3}\right)\right)$ traces. Our algorithm works for all deletion probabilities $q\in(0,1)$.
description: 17 pages, 3 figures
High-Resolution Genome-Wide Analysis of Irradiated (UV and  -Rays) Diploid Yeast Cells Reveals a High Frequency of Genomic Loss of Heterozygosity (LOH) Events
Creators: name: Greenwell, P. W.
name: St. Charles, J.
name: Andersen, S. L.
name: Hazkani-Covo, E.
name: Mieczkowski, P.
name: Malc, E.
name: Yin, Y.
name: Petes, T. D.
name: Dietrich, F. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: In diploid eukaryotes, repair of double-stranded DNA breaks by homologous recombination often leads to loss of heterozygosity (LOH). Most previous studies of mitotic recombination in Saccharomyces cerevisiae have focused on a single chromosome or a single region of one chromosome at which LOH events can be selected. In this study, we used two techniques (single-nucleotide polymorphism microarrays and high-throughput DNA sequencing) to examine genome-wide LOH in a diploid yeast strain at a resolution averaging 1 kb. We examined both selected LOH events on chromosome V and unselected events throughout the genome in untreated cells and in cells treated with either γ-radiation or ultraviolet (UV) radiation. Our analysis shows the following: (1) spontaneous and damage-induced mitotic gene conversion tracts are more than three times larger than meiotic conversion tracts, and conversion tracts associated with crossovers are usually longer and more complex than those unassociated with crossovers; (2) most of the crossovers and conversions reflect the repair of two sister chromatids broken at the same position; and (3) both UV and γ-radiation efficiently induce LOH at doses of radiation that cause no significant loss of viability. Using high-throughput DNA sequencing, we also detected new mutations induced by γ-rays and UV. To our knowledge, our study represents the first high-resolution genome-wide analysis of DNA damage-induced LOH events performed in any eukaryote.
К ВОПРОСУ БЕЗОПАСНОСТИ УЧАСТНИКОВ В УГОЛОВНОМ СУДОПРОИЗВОДСТВЕ
Creators: name: Раджабов Р.О.
Publisher: name: Право и управление
Year: 2022
Subjects: уголовное судопроизводство
уголовный процесс
близкие лица
близкие родственники
государственная защита
посткриминальное воздействие.

description: Статья посвящена проблемам обеспечения безопасности лиц, задействованных в уголовном судопроизводстве. Отмечается, что практика оказания неправомерного воздействия на участников уголовного судопроизводства деструктивно воздействует на правовую систему государства и существенно подрывает авторитет институтов правопорядка и правосудия. Рассмотрена нормативная база по соответствующему сегменту правового массива. Выявлено, что основополагающим актом в исследуемой нами области правоотношений выступает Федеральный закон о государственной защите; закон фиксирует меры государственной защиты и упорядочивает процедуры их применения. Закон, помимо прочего, разграничивает категории государственная защита и меры безопасности. Рассмотрены авторские определения категорий процессуальная безопасность, посткриминальное воздействие и пр. Представлен обзор процессуальных и непроцессуальных мер, применяемых для обеспечения безопасности участников уголовного судопроизводства. Идентифицированы проблемные и дискуссионные аспекты сферы уголовного судопроизводства.
Imputation of Single-Nucleotide Polymorphisms in Inbred Mice Using Local Phylogeny
Creators: name: Cheverud, James M.
name: Churchill, Gary A.
name: de Villena, Fernando Pardo-Manuel
name: Lawson, Heather A.
name: Wang, Jeremy R.
name: McMillan, Leonard
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: We present full-genome genotype imputations for 100 classical laboratory mouse strains, using a novel method. Using genotypes at 549,683 SNP loci obtained with the Mouse Diversity Array, we partitioned the genome of 100 mouse strains into 40,647 intervals that exhibit no evidence of historical recombination. For each of these intervals we inferred a local phylogenetic tree. We combined these data with 12 million loci with sequence variations recently discovered by whole-genome sequencing in a common subset of 12 classical laboratory strains. For each phylogenetic tree we identified strains sharing a leaf node with one or more of the sequenced strains. We then imputed high- and medium-confidence genotypes for each of 88 nonsequenced genomes. Among inbred strains, we imputed 92% of SNPs genome-wide, with 71% in high-confidence regions. Our method produced 977 million new genotypes with an estimated per-SNP error rate of 0.083% in high-confidence regions and 0.37% genome-wide. Our analysis identified which of the 88 nonsequenced strains would be the most informative for improving full-genome imputation, as well as which additional strain sequences will reveal more new genetic variants. Imputed sequences and quality scores can be downloaded and visualized online.
Mitotic Spindle Form and Function
Creators: name: Bloom, K.
name: Winey, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The Saccharomyces cerevisiae mitotic spindle in budding yeast is exemplified by its simplicity and elegance. Microtubules are nucleated from a crystalline array of proteins organized in the nuclear envelope, known as the spindle pole body in yeast (analogous to the centrosome in larger eukaryotes). The spindle has two classes of nuclear microtubules: kinetochore microtubules and interpolar microtubules. One kinetochore microtubule attaches to a single centromere on each chromosome, while approximately four interpolar microtubules emanate from each pole and interdigitate with interpolar microtubules from the opposite spindle to provide stability to the bipolar spindle. On the cytoplasmic face, two to three microtubules extend from the spindle pole toward the cell cortex. Processes requiring microtubule function are limited to spindles in mitosis and to spindle orientation and nuclear positioning in the cytoplasm. Microtubule function is regulated in large part via products of the 6 kinesin gene family and the 1 cytoplasmic dynein gene. A single bipolar kinesin (Cin8, class Kin-5), together with a depolymerase (Kip3, class Kin-8) or minus-end-directed kinesin (Kar3, class Kin-14), can support spindle function and cell viability. The remarkable feature of yeast cells is that they can survive with microtubules and genes for just two motor proteins, thus providing an unparalleled system to dissect microtubule and motor function within the spindle machine.
К ВОПРОСУ О НЕОБХОДИМОСТИ ЗАКОНОДАТЕЛЬНОГО УРЕГУЛИРОВАНИЯ ВОПРОСА СЕМЕЙНО-БЫТОВОГО НАСИЛИЯ В РОССИЙСКОЙ ФЕДЕРАЦИИ. ОПЫТ ЗАРУБЕЖНОГО ЗАКОНОДАТЕЛЬСТВА
Creators: name: Эртнова М.И.
Publisher: name: Право и управление
Year: 2022
Subjects: Семейно-бытовое насилие
закон о профилактике семейно-бытового насилия.

description: Во многих иностранных государствах существует специальный закон, который защищает жертв семейно-бытового насилия. В Российской Федерации существует проект такого закона, но сам закон еще не принят. Споры относительно необходимости принятия законопроекта «О профилактике семейно-бытового насилия в Российской Федерации» ведутся до сих пор. В статье предпринята попытка рассмотреть основные способы защиты жертв семейно-бытового насилия в разных странах и выделить точку зрения о необходимости законодательного урегулирования вопроса защиты жертв семейно-бытового насилия.
Imaging the electron charge density in monolayer MoS2 at the Ångstrom scale
Creators: name: Martis, Joel
name: Susarla, Sandhya
name: Rayabharam, Archith
name: Su, Cong
name: Paule, Timothy
name: Pelz, Philipp
name: Huff, Cassandra
name: Xu, Xintong
name: Li, Hao-Kun
name: Jaikissoon, Marc
name: Chen, Victoria
name: Pop, Eric
name: Saraswat, Krishna
name: Zettl, Alex
name: Aluru, Narayana R.
name: Ramesh, Ramamoorthy
name: Ercius, Peter
name: Majumdar, Arun
Publisher: name: arXiv
Year: 2022
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: Four-dimensional scanning transmission electron microscopy (4D-STEM) has recently gained widespread attention for its ability to image atomic electric fields with sub-Ångstrom spatial resolution. These electric field maps represent the integrated effect of the nucleus, core electrons and valence electrons, and separating their contributions is non-trivial. In this paper, we utilized simultaneously acquired 4D-STEM center of mass (CoM) images and annular dark field (ADF) images to determine the electron charge density in monolayer MoS2. We find that both the core electrons and the valence electrons contribute to the derived electron charge density. However, due to blurring by the probe shape, the valence electron contribution forms a nearly featureless background while most of the spatial modulation comes from the core electrons. Our findings highlight the importance of probe shape in interpreting charge densities derived from 4D STEM.
Implementing a seamless data transfer mechanism between different Research institutions
Creators: name: Tonello, Nadia
name: Wilson, James A J
name: Zarrabi, Narges
Publisher: name: Zenodo
Year: 2023
Subjects: data
OpenScience
ResearchDataManagement
citizenscience
DataInfrastructure
EOSCinPractice
cross-disciplinary

description: The main challenge addressed by the federated B2SAFE service is the lack of a seamless data transfer mechanism between different institutions, which has hindered collaboration and research progress. The ability to share data sets across borders and institutions is essential for researchers to build on each other's work, ultimately leading to more impactful and innovative research. Besides the technical solution that we put in place, there are still challenges from legal and governance perspectives that need to be addressed for sharing data such as having risk assessments and data-sharing agreements between centres.
К ВОПРОСУ О СПОСОБАХ ЗАЩИТЫ ПРАВ СУБЪЕКТОВ ПРЕДПРИНИМАТЕЛЬСКОЙ ДЕЯТЕЛЬНОСТИ В РОССИЙСКОЙ ПРАВОПРИМЕНИТЕЛЬНОЙ ПРАКТИКЕ
Creators: name: Курочкина О.А.
Publisher: name: Право и управление
Year: 2022
Subjects: Защита прав и законных интересов предпринимателя
правовой режим
бизнес
правовая помощь
механизм защиты.

description: Автор в статье рассматривает проблемы защиты прав и законных интересов субъектов предпринимательской деятельности. Категория обороны прав и легитимных интересов коммерсантов владеет двоякой природой. С одной стороны, защита выступает как одно из ведущих субъективных прав соответственного лица, а с другой – осуществление сего права приобретает опосредованный, подчинённый характер. Автор описал проблемы и предложил пути решения.
On the number of maximal intersecting k-uniform families and further applications of Tuza's set pair method
Creators: name: Nagy, Zoltán Lóránt
name: Patkós, Balázs
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05D05, 05A16

description: We study the function $M(n,k)$ which denotes the number of maximal $k$-uniform intersecting families $F\subseteq \binom{[n]}{k}$. Improving a bound of Balogh at al. on $M(n,k)$, we determine the order of magnitude of $\log M(n,k)$ by proving that for any fixed $k$, $M(n,k) =n^{Θ(\binom{2k}{k})}$ holds. Our proof is based on Tuza's set pair approach. The main idea is to bound the size of the largest possible point set of a cross-intersecting system. We also introduce and investigate some related functions and parameters.
description: 11 pages
How does a flexible chain of active particles swell?
Creators: name: Kaiser, Andreas
name: Babel, Sonja
name: Hagen, Borge ten
name: von Ferber, Christian
name: Löwen, Hartmut
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We study the swelling of a flexible linear chain composed of active particles by analytical theory and computer simulation. Three different situations are considered: a free chain, a chain confined to an external harmonic trap, and a chain dragged at one end. First we consider an ideal chain with harmonic springs and no excluded volume between the monomers. The Rouse model of polymers is generalized to the case of self-propelled monomers and solved analytically. The swelling, as characterized by the spatial extension of the chain, scales with the monomer number defining a Flory exponent $ν$ which is $ν=1/2, 0, 1$ in the three different situations. As a result, we find that activity does not change the Flory exponent but affects the prefactor of the scaling law. This can be quantitatively understood by mapping the system onto an equilibrium chain with a higher effective temperature such that the chain swells under an increase of the self-propulsion strength. We then use computer simulations to study the effect of self-avoidance on active polymer swelling. In the three different situations, the Flory exponent is now $ν= 3/4, 1/4, 1$ and again unchanged under self-propulsion. However, the chain extension behaves non-monotonic in the self-propulsion strength.
description: (9 pages, 5 figures)
К ВОПРОСУ ОЦЕНКИ ТЕНДЕНЦИЙ ПРИМЕНЕНИЯ НАСИЛИЯ ПРИ СОВЕРШЕНИИ ПРЕСТУПЛЕНИЙ
Creators: name: Тищенко Ю.Ю.
Publisher: name: Право и управление
Year: 2022
Subjects: насилие
агрессия
жестокость
преступление
принуждение
социум
мораль
нравственность
предупреждение.

description: В статье рассматриваются основные тенденции применения насилия при совершении преступлений против личности, а также отражается значение вышеуказанных тенденций для общества и его нравственного развития. Приводятся выводы о том, что насильственная преступность подчинена контролю и влиянию на нее социального воздействия, что позволяет ее минимизировать путем применения превентивных мер. В заключении сделан вывод, что применение мер превентивного воздействия на проявления насилия на регулярной основе реализуются в нашей стране и оказывают позитивное влияние на его предупреждение. В целом, данные меры больше направлены на сдерживание граждан от совершения насильственных преступлений на определенном социально терпимом уровне, что стало возможным благодаря целенаправленному профилактическому и уголовно-правовому воздействию.
title: An Exploratory Study of Gender and the Process of Negotiating Academic Contracts Among Sociologists
Creators: name: Newton, Miriam M.
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 1996

description: Ample evidence supports the existence of the gender wage gap. One explanation for the gender wage gap in academia may be men's and women's different experiences of the process of negotiating academic contracts. Past literature on gender differences in negotiation suggests that males are more likely to initiate negotiations and are more successful in negotiations than women. This study investigates the process of negotiating academic contracts through a survey of recent PhD graduates in sociology. The research is guided by two questions: (1) What are the experiences of new faculty regarding the process of negotiating academic contracts; and (2) What differences, if any, exist in the negotiating experiences of women and men?
Rapid and Robust Resampling-Based Multiple-Testing Correction with Application in a Genome-Wide Expression Quantitative Trait Loci Study
Creators: name: Huang, S.
name: Sun, W.
name: Wang, W.
name: Zhang, X.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Genome-wide expression quantitative trait loci (eQTL) studies have emerged as a powerful tool to understand the genetic basis of gene expression and complex traits. In a typical eQTL study, the huge number of genetic markers and expression traits and their complicated correlations present a challenging multiple-testing correction problem. The resampling-based test using permutation or bootstrap procedures is a standard approach to address the multiple-testing problem in eQTL studies. A brute force application of the resampling-based test to large-scale eQTL data sets is often computationally infeasible. Several computationally efficient methods have been proposed to calculate approximate resampling-based P-values. However, these methods rely on certain assumptions about the correlation structure of the genetic markers, which may not be valid for certain studies. We propose a novel algorithm, rapid and exact multiple testing correction by resampling (REM), to address this challenge. REM calculates the exact resampling-based P-values in a computationally efficient manner. The computational advantage of REM lies in its strategy of pruning the search space by skipping genetic markers whose upper bounds on test statistics are small. REM does not rely on any assumption about the correlation structure of the genetic markers. It can be applied to a variety of resampling-based multiple-testing correction methods including permutation and bootstrap methods. We evaluate REM on three eQTL data sets (yeast, inbred mouse, and human rare variants) and show that it achieves accurate resampling-based P-value estimation with much less computational cost than existing methods. The software is available at http://csbio.unc.edu/eQTL.
Heisenberg-limited metrology with a squeezed vacuum state, three-mode mixing, and information recycling
Creators: name: Tonekaboni, Behnam
name: Haine, Simon A.
name: Szigeti, Stuart S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We have previously shown that quantum-enhanced atom interferometry can be achieved by mapping the quantum state of squeezed optical vacuum to one of the atomic inputs via a beamsplitter-like process [Phys.~Rev.~A \textbf{90}, 063630 (2014)]. Here we ask the question: is a better phase sensitivity possible if the quantum state transfer (QST) is described by a three-mode-mixing model, rather than a beamsplitter? The answer is yes, but only if the portion of the optical state not transferred to the atoms is incorporated via information recycling. Surprisingly, our scheme gives a better sensitivity for lower QST efficiencies and with a sufficiently large degree of squeezing can attain near-Heisenberg-limited sensitivities for arbitrarily small QST efficiencies. Furthermore, we use the quantum Fisher information to demonstrate the near optimality of our scheme.
description: 10 pages, 6 figures
The Genome Architecture of the Collaborative Cross Mouse Genetic Reference Population
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The Collaborative Cross Consortium reports here on the development of a unique genetic resource population. The Collaborative Cross (CC) is a multiparental recombinant inbred panel derived from eight laboratory mouse inbred strains. Breeding of the CC lines was initiated at multiple international sites using mice from The Jackson Laboratory. Currently, this innovative project is breeding independent CC lines at the University of North Carolina (UNC), at Tel Aviv University (TAU), and at Geniad in Western Australia (GND). These institutions aim to make publicly available the completed CC lines and their genotypes and sequence information. We genotyped, and report here, results from 458 extant lines from UNC, TAU, and GND using a custom genotyping array with 7500 SNPs designed to be maximally informative in the CC and used a novel algorithm to infer inherited haplotypes directly from hybridization intensity patterns. We identified lines with breeding errors and cousin lines generated by splitting incipient lines into two or more cousin lines at early generations of inbreeding. We then characterized the genome architecture of 350 genetically independent CC lines. Results showed that founder haplotypes are inherited at the expected frequency, although we also consistently observed highly significant transmission ratio distortion at specific loci across all three populations. On chromosome 2, there is significant overrepresentation of WSB/EiJ alleles, and on chromosome X, there is a large deficit of CC lines with CAST/EiJ alleles. Linkage disequilibrium decays as expected and we saw no evidence of gametic disequilibrium in the CC population as a whole or in random subsets of the population. Gametic equilibrium in the CC population is in marked contrast to the gametic disequilibrium present in a large panel of classical inbred strains. Finally, we discuss access to the CC population and to the associated raw data describing the genetic structure of individual lines. Integration of rich phenotypic and genomic data over time and across a wide variety of fields will be vital to delivering on one of the key attributes of the CC, a common genetic reference platform for identifying causative variants and genetic networks determining traits in mammals.
Ultraconserved Elements in the Human Genome: Association and Transmission Analyses of Highly Constrained Single-Nucleotide Polymorphisms
Creators: name: Wilson, J. G.
name: North, K. E.
name: Keating, B. J.
name: Lettre, G.
name: Cupples, L. A.
name: Boerwinkle, E.
name: Demerath, E. W.
name: Nock, N. L.
name: Chiang, C. W. K.
name: Reiner, A. P.
name: Liu, C.-T.
name: Hirschhorn, J. N.
name: Franceschini, N.
name: Vedantam, S.
name: Rotter, J. I.
name: Jorgensen, N. W.
name: Papanicolaou, G. J.
name: Murabito, J. M.
name: Lange, L. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Ultraconserved elements in the human genome likely harbor important biological functions as they are dosage sensitive and are able to direct tissue-specific expression. Because they are under purifying selection, variants in these elements may have a lower frequency in the population but a higher likelihood of association with complex traits. We tested a set of highly constrained SNPs (hcSNPs) distributed genome-wide among ultraconserved and nearly ultraconserved elements for association with seven traits related to reproductive (age at natural menopause, number of children, age at first child, and age at last child) and overall [longevity, body mass index (BMI), and height] fitness. Using up to 24,047 European-American samples from the National Heart, Lung, and Blood Institute Candidate Gene Association Resource (CARe), we observed an excess of associations with BMI and height. In an independent replication panel the most strongly associated SNPs showed an 8.4-fold enrichment of associations at the nominal level, including three variants in previously identified loci and one in a locus (DENND1A) previously shown to be associated with polycystic ovary syndrome. Finally, using 1430 family trios, we showed that the transmissions from heterozygous parents to offspring of the derived alleles of rare (frequency ≤0.5%) hcSNPs are not biased, particularly after adjusting for the rates of genotype missingness and error in the data. The lack of transmission bias ruled out an immediately and strongly deleterious effect due to the rare derived alleles, consistent with the observation that mice homozygous for the deletion of ultraconserved elements showed no overt phenotype. Our study also illustrated the importance of carefully modeling potential technical confounders when analyzing genotype data of rare variants.
SDSS J013127.34-032100.1: a candidate blazar with a 11 billion solar mass black hole at $z$=5.18
Creators: name: Ghisellini, G.
name: Tagliaferri, G.
name: Sbarrato, T.
name: Gehrels, N.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The radio-loud quasar SDSS J013127.34-032100.1at a redshift z=5.18 is one of the most distant radio-loud objects. The radio to optical flux ratio (i.e. the radio-loudness) of the source is large, making it a promising blazar candidate. Its overall spectral energy distribution, completed by the X-ray flux and spectral slope derived through Target of Opportunity Swift/XRT observations, is interpreted by a non-thermal jet plus an accretion disc and molecular torus model. We estimate that its black hole mass is (1.1+-0.2)1e10 Msun. for an accretion efficiency eta=0.08, scaling roughly linearly with eta. Although there is a factor ~2 of systematic uncertainty, this black hole mass is the largest found at these redshifts in a radio loud object. We derive a viewing angle between 3 and 5 degrees. This implies that there must be other (hundreds) sources with the same black hole mass of SDSS J013127.34-032100.1, but whose jets are pointing away from Earth. We discuss the problems posed by the existence of such large black hole masses at such redshifts, especially in jetted quasars. In fact, if they are associated to rapidly spinning black holes, the accretion efficiency is high, implying a slower pace of black hole growth with respect to radio-quiet quasars.
description: Acceptedd for publication as a Letter in MNRAS, in press. 5 pages, 1 table, 4 figures
Varying Coefficient Models for Mapping Quantitative Trait Loci Using Recombinant Inbred Intercrosses
Creators: name: Zou, Fei
name: Gong, Yi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: There has been a great deal of interest in the development of methodologies to map quantitative trait loci (QTL) using experimental crosses in the last 2 decades. Experimental crosses in animal and plant sciences provide important data sources for mapping QTL through linkage analysis. The Collaborative Cross (CC) is a renewable mouse resource that is generated from eight genetically diverse founder strains to mimic the genetic diversity in humans. The recombinant inbred intercrosses (RIX) generated from CC recombinant inbred (RI) lines share similar genetic structures of F2 individuals but with up to eight alleles segregating at any one locus. In contrast to F2 mice, genotypes of RIX can be inferred from the genotypes of their RI parents and can be produced repeatedly. Also, RIX mice typically do not share the same degree of relatedness. This unbalanced genetic relatedness requires careful statistical modeling to avoid false-positive findings. Many quantitative traits are inherently complex with genetic effects varying with other covariates, such as age. For such complex traits, if phenotype data can be collected over a wide range of ages across study subjects, their dynamic genetic patterns can be investigated. Parametric functions, such as sigmoidal or logistic functions, have been used for such purpose. In this article, we propose a flexible nonparametric time-varying coefficient QTL mapping method for RIX data. Our method allows the QTL effects to evolve with time and naturally extends classical parametric QTL mapping methods. We model the varying genetic effects nonparametrically with the B-spline bases. Our model investigates gene-by-time interactions for RIX data in a very flexible nonparametric fashion. Simulation results indicate that the varying coefficient QTL mapping has higher power and mapping precision compared to parametric models when the assumption of constant genetic effects fails. We also apply a modified permutation procedure to control overall significance level.
A Locus in Drosophila sechellia Affecting Tolerance of a Host Plant Toxin
Creators: name: Moran, Jennifer R.
name: Turissini, David A.
name: Earley, Eric J.
name: Jones, Corbin D.
name: Wu, Chung-I
name: Wu, Mao-Lien
name: Ting, Chau-Ti
name: Hungate, Eric A.
name: Boussy, Ian A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Many insects feed on only one or a few types of host. These host specialists often evolve a preference for chemical cues emanating from their host and develop mechanisms for circumventing their host’s defenses. Adaptations like these are central to evolutionary biology, yet our understanding of their genetics remains incomplete. Drosophila sechellia, an emerging model for the genetics of host specialization, is an island endemic that has adapted to chemical toxins present in the fruit of its host plant, Morinda citrifolia. Its sibling species, D. simulans, and many other Drosophila species do not tolerate these toxins and avoid the fruit. Earlier work found a region with a strong effect on tolerance to the major toxin, octanoic acid, on chromosome arm 3R. Using a novel assay, we narrowed this region to a small span near the centromere containing 18 genes, including three odorant binding proteins. It has been hypothesized that the evolution of host specialization is facilitated by genetic linkage between alleles contributing to host preference and alleles contributing to host usage, such as tolerance to secondary compounds. We tested this hypothesis by measuring the effect of this tolerance locus on host preference behavior. Our data were inconsistent with the linkage hypothesis, as flies bearing this tolerance region showed no increase in preference for media containing M. citrifolia toxins, which D. sechellia prefers. Thus, in contrast to some models for host preference, preference and tolerance are not tightly linked at this locus nor is increased tolerance per se sufficient to change preference. Our data are consistent with the previously proposed model that the evolution of D. sechellia as a M. citrifolia specialist occurred through a stepwise loss of aversion and gain of tolerance to M. citrifolia’s toxins.
A Novel Intronic Single Nucleotide Polymorphism in the Myosin heavy polypeptide 4 Gene Is Responsible for the Mini-Muscle Phenotype Characterized by Major Reduction in Hind-Limb Muscle Mass in Mice
Creators: name: Selitsky, S. R.
name: Weinstock, G. M.
name: Kelly, S. A.
name: Buus, R. J.
name: Hua, K.
name: Bell, T. A.
name: Pardo-Manuel de Villena, F.
name: Pomp, D.
name: Garland, T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Replicated artificial selection for high levels of voluntary wheel running in an outbred strain of mice favored an autosomal recessive allele whose primary phenotypic effect is a 50% reduction in hind-limb muscle mass. Within the High Runner (HR) lines of mice, the numerous pleiotropic effects (e.g., larger hearts, reduced total body mass and fat mass, longer hind-limb bones) of this hypothesized adaptive allele include functional characteristics that facilitate high levels of voluntary wheel running (e.g., doubling of mass-specific muscle aerobic capacity, increased fatigue resistance of isolated muscles, longer hind-limb bones). Previously, we created a backcross population suitable for mapping the responsible locus. We phenotypically characterized the population and mapped the Minimsc locus to a 2.6-Mb interval on MMU11, a region containing ∼100 known or predicted genes. Here, we present a novel strategy to identify the genetic variant causing the mini-muscle phenotype. Using high-density genotyping and whole-genome sequencing of key backcross individuals and HR mice with and without the mini-muscle mutation, from both recent and historical generations of the HR lines, we show that a SNP representing a C-to-T transition located in a 709-bp intron between exons 11 and 12 of the Myosin heavy polypeptide 4 (Myh4) skeletal muscle gene (position 67,244,850 on MMU11; assembly, December 2011, GRCm38/mm10; ENSMUSG00000057003) is responsible for the mini-muscle phenotype, Myh4Minimsc. Using next-generation sequencing, our approach can be extended to identify causative mutations arising in mouse inbred lines and thus offers a great avenue to overcome one of the most challenging steps in quantitative genetics.
Gene Copy-Number Variation in Haploid and Diploid Strains of the Yeast Saccharomyces cerevisiae
Creators: name: Song, W.
name: Malc, E.
name: Petes, T. D.
name: Greenwell, P. W.
name: Zhang, H.
name: Puccia, C. M.
name: Zeidler, A. F. B.
name: Mieczkowski, P. A.
name: Argueso, J. L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The increasing ability to sequence and compare multiple individual genomes within a species has highlighted the fact that copy-number variation (CNV) is a substantial and underappreciated source of genetic diversity. Chromosome-scale mutations occur at rates orders of magnitude higher than base substitutions, yet our understanding of the mechanisms leading to CNVs has been lagging. We examined CNV in a region of chromosome 5 (chr5) in haploid and diploid strains of Saccharomyces cerevisiae. We optimized a CNV detection assay based on a reporter cassette containing the SFA1 and CUP1 genes that confer gene dosage-dependent tolerance to formaldehyde and copper, respectively. This optimized reporter allowed the selection of low-order gene amplification events, going from one copy to two copies in haploids and from two to three copies in diploids. In haploid strains, most events involved tandem segmental duplications mediated by nonallelic homologous recombination between flanking direct repeats, primarily Ty1 elements. In diploids, most events involved the formation of a recurrent nonreciprocal translocation between a chr5 Ty1 element and another Ty1 repeat on chr13. In addition to amplification events, a subset of clones displaying elevated resistance to formaldehyde had point mutations within the SFA1 coding sequence. These mutations were all dominant and are proposed to result in hyperactive forms of the formaldehyde dehydrogenase enzyme.
Exact results for itinerant ferromagnetism in a $t_{2g}$ orbital system on cubic and square lattices
Creators: name: Li, Yi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We study itinerant ferromagnetism in a $t_{2g}$ multi-orbital Hubbard system in the cubic lattice, which consists of three planar oriented orbital bands of $d_{xy}$, $d_{yz}$, and $d_{zx}$. Electrons in each orbital band can only move within a two-dimensional plane in the three-dimensional lattice parallel to the corresponding orbital orientation. Electrons of different orbitals interact through the on-site multi-orbital interactions including Hund's coupling. The strong coupling limit is considered in which there are no doubly occupied orbitals but multiple on-site occupations are allowed. We show that, in the case in which there is one and only one hole for each orbital band in each layer parallel to the orbital orientation, the ground state is a fully spin-polarized itinerant ferromagnetic state, which is unique apart from the trivial spin degeneracy. When the lattice is reduced into a single two-dimensional layer, the $d_{zx}$ and $d_{yz}$ bands become quasi-one-dimensional while the $d_{xy}$ band remains two-dimensional. The ground state ferromagnetism also appears in the strong-coupling limit as a generalization of the double exchange mechanism. Possible applications to the systems of SrRuO$_3$ and LaAlO$_3$/SrTiO$_3$ interface are discussed.
НЕКОТОРЫЕ ВОПРОСЫ РАСКРЫТИЯ И РАССЛЕДОВАНИЯ ПРЕСТУПЛЕНИЙ «ПО ГОРЯЧИМ СЛЕДАМ»
Creators: name: Прокуденкова Т.М.
name: Старичков М.В.
Publisher: name: Право и управление
Year: 2022
Subjects: «по горячим следам»
раскрытие преступления
первоначальный этап расследования
следователь
следственно-оперативная группа
криминалистические учеты
технико-криминалистические средства
получение информации о соединениях между абонентами и (или) абонентскими устройствами
абонентское устройство
геолокация.

description: Правильно организованное расследование преступлений «по горячим следам» может обеспечить высокую вероятность его раскрытия. В статье рассматриваются факторы, которые непосредственно определяют сам факт необходимости такого расследования и факторы, которые опосредуют его эффективность. Отмечается большая роль современного технико-криминалистического оснащения для экспресс-диагностики следов преступления, а также использование криминалистических учетов для получения информации, значимой для расследования «по горячим следам». Особое внимание уделяется вопросу получения информации о соединениях между абонентскими устройствами и их геолокации.
Crystalline Quantum Circuits
Creators: name: Sommers, Grace M.
name: Huse, David A.
name: Gullans, Michael J.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Random quantum circuits continue to inspire a wide range of applications in quantum information science and many-body quantum physics, while remaining analytically tractable through probabilistic methods. Motivated by an interest in deterministic circuits with similar applications, we construct classes of \textit{nonrandom} unitary Clifford circuits by imposing translation invariance in both time and space. Further imposing dual-unitarity, our circuits effectively become crystalline spacetime lattices whose vertices are SWAP or iSWAP two-qubit gates and whose edges may contain one-qubit gates. One can then require invariance under (subgroups of) the crystal's point group. Working on the square and kagome lattices, we use the formalism of Clifford quantum cellular automata to describe operator spreading, entanglement generation, and recurrence times of these circuits. A full classification on the square lattice reveals, of particular interest, a "nonfractal good scrambling class" with dense operator spreading that generates codes with linear contiguous code distance and high performance under erasure errors at the end of the circuit. We also break unitarity by adding spacetime-translation-invariant measurements and find a class of such circuits with fractal dynamics.
description: 28 pages, 23 figures + 6 pages, 5 figures in 3 appendices. v2: Added two appendices, revised and added references. v3: Improved presentation based on referee comments, close to published version. See also https://errorcorrectionzoo.org/c/crystalline_dynamic_gen
НЕКОТОРЫЕ АСПЕКТЫ ЗАЩИТЫ ПРАВ ОСУЖДЕННЫХ ПРИ ПРИВАТИЗАЦИИ ЖИЛЫХ ПОМЕЩЕНИЙ
Creators: name: Шелепина Е.А.
Publisher: name: Право и управление
Year: 2022
Subjects: приватизация
жилые помещения
осужденные
защита
гражданское право
собственность.

description: Статья посвящена вопросам гражданско-правовой защиты прав лиц, находящихся в местах принудительного содержания, при приватизации жилых помещений. Проблемные вопросы у данной категории граждан возникают как в связи с невозможностью приватизации жилья в силу различных юридических или фактических препятствий, так и в силу недобросовестных действий третьих лиц, в том числе членов их семьи. Автор анализирует общие принципы приватизации жилых помещений, особенности участия в данных правоотношениях лиц, находящихся в местах принудительного содержания, правоприменительную практику по оспариванию договоров приватизации жилых помещений. По итогам исследования сделан вывод о юридически значимых обстоятельствах при рассмотрении судом споров о защите прав данной категории лиц при приватизации жилья.
Meiotic and Mitotic Recombination in Meiosis
Creators: name: Sekelsky, J.
name: Kohl, K. P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Meiotic crossovers facilitate the segregation of homologous chromosomes and increase genetic diversity. The formation of meiotic crossovers was previously posited to occur via two pathways, with the relative use of each pathway varying between organisms; however, this paradigm could not explain all crossovers, and many of the key proteins involved were unidentified. Recent studies that identify some of these proteins reinforce and expand the model of two meiotic crossover pathways. The results provide novel insights into the evolutionary origins of the pathways, suggesting that one is similar to a mitotic DNA repair pathway and the other evolved to incorporate special features unique to meiosis.
Modeling Neighborhood Change to Mitigate Gentrification: A Case Study of Fairfax County, Virginia
Publisher: name: University of Virginia
Year: 2021
Subjects: American Community Survey
Housing policy
Vulnerability
Socio-demographic change

description: Gentrification describes the transformation of working-class or vacant areas into middle-class residential or commercial zones through an influx of affluent persons and businesses displacing long-term, vulnerable populations. Local governments often lack resources to detect gentrification emergence and mitigate its negative impacts. We demonstrate how studying gentrification at granular geographies using publicly available data can provide actionable insights to stakeholders seeking to preserve neighborhood diversity and protect at-risk residents. We examine neighborhood change in Fairfax County, VA using US Census Bureau American Community Survey 5-year estimates (2008/12-2014/18). Using three multifactor dimensions to measure gentrification, we classify census tracts into those not vulnerable to gentrification at baseline; vulnerable but not gentrified, and vulnerable and gentrified over time. We employ a spatial generalized linear mixed model to examine property and population factors associated with gentrification and test the effects of a hypothetical housing policy intervention. Results suggest that 61% of Fairfax County tracts were not vulnerable and 39% were vulnerable to gentrification at baseline. Of those vulnerable, 49% did not gentrify over time. The remaining 51% experienced significant socioeconomic and investment change, gentrifying during the period. Median property values, college-educated population, and white population shares were associated with increased gentrification likelihood. Finally, we show that a 10% median property value reduction intervention would result in 26% fewer vulnerable and 50% fewer gentrified areas. We conclude with policy recommendations mitigating gentrification and highlight how public data and modeling could assist local governments with decision-making, maximizing the impact of county resources, and improving neighborhood outcomes.
Nonrandom Distribution of Interhomolog Recombination Events Induced by Breakage of a Dicentric Chromosome in Saccharomyces cerevisiae
Creators: name: Greenwell, P. W.
name: Petes, T. D.
name: Gawel, M.
name: Dominska, M.
name: Hazkani-Covo, E.
name: Bloom, K.
name: Song, W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Dicentric chromosomes undergo breakage in mitosis, resulting in chromosome deletions, duplications, and translocations. In this study, we map chromosome break sites of dicentrics in Saccharomyces cerevisiae by a mitotic recombination assay. The assay uses a diploid strain in which one homolog has a conditional centromere in addition to a wild-type centromere, and the other homolog has only the wild-type centromere; the conditional centromere is inactive when cells are grown in galactose and is activated when the cells are switched to glucose. In addition, the two homologs are distinguishable by multiple single-nucleotide polymorphisms (SNPs). Under conditions in which the conditional centromere is activated, the functionally dicentric chromosome undergoes double-stranded DNA breaks (DSBs) that can be repaired by mitotic recombination with the homolog. Such recombination events often lead to loss of heterozygosity (LOH) of SNPs that are centromere distal to the crossover. Using a PCR-based assay, we determined the position of LOH in multiple independent recombination events to a resolution of ∼4 kb. This analysis shows that dicentric chromosomes have recombination breakpoints that are broadly distributed between the two centromeres, although there is a clustering of breakpoints within 10 kb of the conditional centromere.