cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Differential Roles of Arabidopsis Heterotrimeric G-Protein Subunits in Modulating Cell Division in Roots
Creators: name: Chen, J.-G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Signaling through heterotrimeric G proteins is conserved in diverse eukaryotes. Compared to vertebrates, the simpler repertoire of G-protein complex and accessory components in Arabidopsis (Arabidopsis thaliana) offers a unique advantage over all other multicellular, genetic-model systems for dissecting the mechanism of G-protein signal transduction. One of several biological processes that the G-protein complex regulates in Arabidopsis is cell division. We determined cell production rate in the primary root and the formation of lateral roots in Arabidopsis to define individually the types of modulatory roles of the respective G-protein α- and β-subunits, as well as the heterotrimer in cell division. The growth rate of the root is in part a consequence of cell cycle maintenance in the root apical meristem (RAM), while lateral root production requires meristem formation by founder pericycle cells. Thus, a comparison of these two parameters in various genetic backgrounds enabled dissection of the role of the G-protein subunits in modulation of cell division, both in maintenance and initiation. Cell production rates were determined for the RAM and lateral root formation in gpa1 (Arabidopsis G-protein α-subunit) and agb1 (Arabidopsis G-protein β-subunit) single and double mutants, and in transgenic lines overexpressing GPA1 or AGB1 in agb1 or gpa1 mutant backgrounds, respectively. We found in the RAM that the heterotrimeric complex acts as an attenuator of cell proliferation, whereas the GTP-bound form of the Gα-subunit's role is a positive modulator. In contrast, for the formation of lateral roots, the Gβγ-dimer acts largely independently of the Gα-subunit to attenuate cell division. These results suggest that Arabidopsis heterotrimeric G-protein subunits have differential and opposing roles in the modulation of cell division in roots.
Trends in the Number and Type of Tobacco Product Retailers, United States, 2000-2017
Creators: name: Delamater, P.L.
name: Golden, S.D.
name: Baggett, C.D.
name: Ribisl, K.M.
name: Kong, A.Y.
name: Tao, V.Q.
name: Kuo, T.-M.
Publisher: name: Oxford University Press
Year: 2022

description: Introduction: Tobacco product retailers provide access to tobacco products and exposure to tobacco marketing. Without a national tobacco retailer licensing system in the United States, there are no estimates of national trends in tobacco retailer numbers and store type over time. Methods: We developed a protocol to identify likely tobacco retailers across the United States between 2000 and 2017 using industry codes and retailer names in the annual National Establishment Time Series (NETS) database. We calculated annual counts of tobacco retailers in seven store-type categories and annual numbers of tobacco retailers that opened and closed. Results: We estimate that there were 317 492 tobacco product retailers in 2000; the number grew to 412 536 in 2009 before falling to 356 074 in 2017, for a net 12% increase overall. Gas/convenience stores and grocery stores accounted for more than two thirds of all retailers. On average, new openings accounted for 8.0% of the total retailers, whereas 7.3% of retailers closed or stopped selling tobacco each year, with stronger market volatility following the Great Recession. Since 2011, there was a disproportionate reduction in tobacco-selling pharmacies and an increase in both tobacco-specialty shops and tobacco-selling discount stores. Conclusions: During two decades when smoking declined, tobacco retailer availability increased in the United States. The economic climate, corporate and public policies, and new tobacco products may all contribute to trends in tobacco retailer availability. State and local jurisdictions considering tobacco retailer policies may find retailer trend information useful for forecasting or evaluating potential policy impacts. Implications: This study provides historic data tracking tobacco retailers in the United States between 2000 and 2017, documenting trends that unfolded as the general economic market contracted and grew, with greater regulation of the tobacco retailer environment. These data provide a context for better understanding future changes in the tobacco retailer market. In addition, the protocol established in this study could be applied in any US-based location without tobacco retailer licensing to allow identification of stores and tracking of trends.
Non-separability of the Lipschitz distance
Creators: name: Suzuki, Kohei
name: Yamazaki, Yohei
Publisher: name: arXiv
Year: 2014
Subjects: subject: Metric Geometry (math.MG)
subject: FOS: Mathematics
subject: Primary 53C23, Secondary 53C20

description: Let $X$ be a compact metric space and $\mathcal M_X$ be the set of isometry classes of compact metric spaces $Y$ such that the Lipschitz distance $d_L(X,Y)$ is finite. We show that $(\mathcal M_X, d_L)$ is not separable when $X$ is a closed interval, or an infinite union of shrinking closed intervals.
description: 17 pages, 2 figures
Validity of breast cancer surgery treatment information in a state-based cancer registry
Creators: name: Wheeler, S.B.
name: Robinson, W.R.
name: Baggett, C.D.
name: Reeder-Hayes, K.E.
name: Olshan, A.F.
name: Roberson, M.L.
name: Nichols, H.B.
Publisher: name: Springer Science and Business Media Deutschland GmbH
Year: 2022

description: Purpose: Surgery is an important part of early stage breast cancer treatment that affects overall survival. Many studies of surgical treatment of breast cancer rely on data sources that condition on continuous insurance coverage or treatment at specified facilities and thus under-sample populations especially affected by cancer care inequities including the uninsured and rural populations. Statewide cancer registries contain data on first course of cancer treatment for all patients diagnosed with cancer but the accuracy of these data are uncertain. Methods: Patients diagnosed with stage I–III breast cancer between 2003 and 2016 were identified using the North Carolina Central Cancer Registry and linked to Medicaid, Medicare, and private insurance claims. We calculated the sensitivity, specificity, positive predictive value, negative predictive value, and Kappa statistics for receipt of surgery and type of surgery (breast conserving surgery or mastectomy) using the insurance claims as the presumed gold standard. Analyses were stratified by race, insurance type, and rurality. Results: Of 26,819 patients who met eligibility criteria, 23,125 were identified as having surgery in both the claims and registry for a sensitivity of 97.9% (95% CI 97.8%, 98.1%). There was also strong agreement for surgery type between the cancer registry and the insurance claims (Kappa: 0.91). Registry treatment data validity was lower for Medicaid insured patients than for Medicare and commercially insured patients. Conclusions: Cancer registry treatment data reliably identified receipt and type of breast cancer surgery. Cancer registries are an important source of data for understanding cancer care in underrepresented populations.
Meissner Effect of Dirac Electrons in Superconducting State due to Inter-band Effect
Creators: name: Mizoguchi, Tomonari
name: Ogata, Masao
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Dirac electrons in solids show characteristic physical properties due to their linear dispersion relation and two-band nature. Although the transport phenomena of Dirac electrons in a normal state have intensively been studied, the transport phenomena in a superconducting state have not been fully understood. In particular, it is not clear whether Dirac electrons in a superconducting state show Meissner effect (ME), since a diamagnetic term of a current operator is absent as a result of the linear dispersion. We investigate the ME of three dimensional massive Dirac electrons in a superconducting state on the basis of Kubo formula, and clarify that Meissner kernel becomes finite by use of the inter-band contribution. This mechanism of the ME for Dirac electrons is completely different from that for the electrons in usual metals. Our result shows that the Meissner kernel remains finite even when the superconducting gap vanishes. This is an unavoidable problem in the Dirac electron system as reported in the previous works. Thus, we use a prescription in which we subtract the normal state contribution. In order to justify this prescription, we develop a specific model where the Meissner kernel is obtained by the prescription. We also derive the result for the electron gas by taking the non-relativistic limit of Dirac Hamiltonian, and clarify that the diamagnetic term of the Meissner kernel can be regarded as the inter-band contribution between electrons and positrons in terms of the Dirac model.
description: 7 pages, 5 figures. To be published in J. Phys. Soc. Jpn
Differential-geometrical approach to the dynamics of dissipationless incompressible Hall magnetohydrodynamics I: Lagrangian mechanics on semidirect product of two volume preserving diffeomorphisms and conservation laws
Creators: name: Araki, Keisuke
Publisher: name: arXiv
Year: 2014
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: The dynamics of a dissipationless incompressible Hall magnetohydrodynamic (HMHD) medium is formulated using Lagrangian mechanics on a semidirect product of two volume preserving diffeomorphism groups. In the case of $\mathbb{T}^3$ or $E^3$, the generalized Elsasser variables introduced by Galtier (S. Galtier 2006 J. Plasma Phys. 72 721-769) yield remarkably simple expressions of basic formulas and equations such as the structure constants of Lie algebra, the equation of motion, and the conservation laws. Four constants of motion, where three of the four are independent, are naturally derived from the generalized Elsasser variables representation of the equation of motion for the HMHD system: total plasma energy, magnetic helicity, hybrid helicity, and the modified cross helicity.
description: In this version, some errors, typos, and some dropped references in the previous version are corrected
G-Protein Complex Mutants Are Hypersensitive to Abscisic Acid Regulation of Germination and Postgermination Development
Creators: name: Pandey, S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Abscisic acid (ABA) plays regulatory roles in a host of physiological processes throughout plant growth and development. Seed germination, early seedling development, stomatal guard cell functions, and acclimation to adverse environmental conditions are key processes regulated by ABA. Recent evidence suggests that signaling processes in both seeds and guard cells involve heterotrimeric G proteins. To assess new roles for the Arabidopsis (Arabidopsis thaliana) Gα subunit (GPA1), the Gβ subunit (AGB1), and the candidate G-protein-coupled receptor (GCR1) in ABA signaling during germination and early seedling development, we utilized knockout mutants lacking one or more of these components. Our data show that GPA1, AGB1, and GCR1 each negatively regulates ABA signaling in seed germination and early seedling development. Plants lacking AGB1 have greater ABA hypersensitivity than plants lacking GPA1, suggesting that AGB1 is the predominant regulator of ABA signaling and that GPA1 affects the efficacy of AGB1 execution. GCR1 acts upstream of GPA1 and AGB1 for ABA signaling pathways during germination and early seedling development: gcr1 gpa1 double mutants exhibit a gpa1 phenotype and agb1 gcr1 and agb1 gcr1 gpa1 mutants exhibit an agb1 phenotype. Contrary to the scenario in guard cells, where GCR1 and GPA1 have opposite effects on ABA signaling during stomatal opening, GCR1 acts in concert with GPA1 and AGB1 in ABA signaling during germination and early seedling development. Thus, cell- and tissue-specific functional interaction in response to a given signal such as ABA may determine the distinct pathways regulated by the individual members of the G-protein complex.
Remnant Symmetry, Propagation and Evolution in f(T) Gravity
Creators: name: Chen, Pisin
name: Izumi, Keisuke
name: Nester, James M.
name: Ong, Yen Chin
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: It was recently argued that f(T) gravity could inherit "remnant symmetry" from the full Lorentz group, despite the fact that the theory is not locally Lorentz invariant. Confusion has arisen regarding the implication of this result for the previous works, which established that f(T) gravity is pathological due to superluminal propagation, local acausality, and non-unique time evolution. We clarify that the existence of the "remnant group" does not rid the theory of these various problems, but instead strongly supports it.
description: Fixed typo. Version accepted by PRD
Metadaten zu Open-Access-Büchern in BASE
Creators: name: Pieper, Dirk
Publisher: name: Kolloquium Wissensinfrastruktur
Year: 2022

description: BASE (Bielefeld Academic Search Engine) ist mit Nachweisen zu über 310 Millionen Dokumenten eine der weltweit größten Suchmaschinen für wissenschaftliche Dokumente im Netz. Systemübergreifende Metadatenkommunikation und -Standardisierung sind dabei grundlegende Voraussetzungen für die Entwicklung von BASE und vergleichbaren Informationssystemen. Der Vortrag legt den Fokus auf die Metadaten zu Open-Access-Büchern und Buchkapiteln in BASE, deren Anteil am Gesamtindex in den letzten Jahren deutlich gestiegen ist, und verdeutlicht die Herausforderung der weiteren Dissemination von Metadaten zu Open-Access-Büchern. Mit dieser Expertise beteiligt sich die UB Bielefeld zudem an dem im kommenden Jahr startenden EU-Projekt „PALOMERA“, über dessen Zielsetzung der Vortrag ebenfalls informiert.
description: Kolloquium Wissensinfrastruktur, Wintersemester 2022/23
Vacuum condensate, geometric phase, Unruh effect and temperature measurement
Creators: name: Capolupo, A.
name: Vitiello, G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In our previous work it has been shown the possibility to use the Aharonov-Anandan invariant as a tool in the analysis of disparate systems, including Hawking and Unruh effects, as well as graphene physics and thermal states. We show that the vacuum condensation, characterizing such systems, is also related with geometric phases and we analyze the properties of the geometric phase of systems represented by mixed state and undergoing a nonunitary evolution. In particular, we consider two level atoms accelerated by an external potential and interacting with a thermal state. We propose the realization of Mach-Zehnder interferometers which can prove the existence of the Unruh effect and can allow very precise measurements of temperature.
description: 8 pages, 2 figures
Nomenclature for two-component signaling elements of rice [1]
Creators: name: Mizuno, T.
name: Pareek, A.
name: Kieber, J. J.
name: Hwang, I.
name: Kurata, N.
name: Khurana, J. P.
name: Shiu, S.-H.
name: Wu, P.
name: Schaller, G. E.
name: Doi, K.
name: Yip, W. K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Plants make use of two-component systems for signal transduction, and these are involved in vital cellular processes such as the responses to cytokinins, ethylene, red/far-red light, and osmosensing ([Schaller et al., 2002][1]). Two-component systems were originally identified in bacteria, and in
RCN1-Regulated Phosphatase Activity and EIN2 Modulate Hypocotyl Gravitropism by a Mechanism That Does Not Require Ethylene Signaling
Creators: name: Muday, G. K.
name: DeLong, A.
name: Kieber, J. J.
name: Brady, S. R.
name: Deruere, J.
name: Argueso, C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: The roots curl in naphthylphthalamic acid1 (rcn1) mutant of Arabidopsis (Arabidopsis thaliana) has altered auxin transport, gravitropism, and ethylene response, providing an opportunity to analyze the interplay between ethylene and auxin in control of seedling growth. Roots of rcn1 seedlings were previously shown to have altered auxin transport, growth, and gravitropism, while rcn1 hypocotyl elongation exhibited enhanced ethylene response. We have characterized auxin transport and gravitropism phenotypes of rcn1 hypocotyls and have explored the roles of auxin and ethylene in controlling these phenotypes. As in roots, auxin transport is increased in etiolated rcn1 hypocotyls. Hypocotyl gravity response is accelerated, although overall elongation is reduced, in etiolated rcn1 hypocotyls. Etiolated, but not light grown, rcn1 seedlings also overproduce ethylene, and mutations conferring ethylene insensitivity restore normal hypocotyl elongation to rcn1. Auxin transport is unaffected by treatment with the ethylene precursor 1-aminocyclopropane carboxylic acid in etiolated hypocotyls of wild-type and rcn1 seedlings. Surprisingly, the ethylene insensitive2-1 (ein2-1) and ein2-5 mutations dramatically reduce gravitropic bending in hypocotyls. However, the ethylene resistant1-3 (etr1-3) mutation does not significantly affect hypocotyl gravity response. Furthermore, neither the etr1 nor the ein2 mutation abrogates the accelerated gravitropism observed in rcn1 hypocotyls, indicating that both wild-type gravity response and enhanced gravity response in rcn1 do not require an intact ethylene-signaling pathway. We therefore conclude that the RCN1 protein affects overall hypocotyl elongation via negative regulation of ethylene synthesis in etiolated seedlings, and that RCN1 and EIN2 modulate hypocotyl gravitropism and ethylene responses through independent pathways.
Patterns and Predictors of Oral Anticancer Agent Use in Diverse Patients with Metastatic Renal Cell Carcinoma
Creators: name: Greiner, M.A.
name: Dinan, M.A.
name: Pritchard, J.E.
name: Wilson, L.E.
name: Scales, C.D., Jr.
name: Zhang, T.
name: Jackson, B.E.
name: Wheeler, S.B.
name: Baggett, C.D.
name: Spees, L.P.
name: George, D.
name: Kaye, D.R.
Publisher: name: American Society of Clinical Oncology
Year: 2021

description: PURPOSE Availability of targeted oral anticancer agents (OAAs) has transformed care for patients with metastatic renal cell carcinoma (mRCC). Our objective was to identify patterns and predictors of OAA use within 12 months after mRCC was detected to understand real-world adoption of OAAs. METHODS We used a novel, North Carolina cancer registry–linked multipayer claims data resource to examine patterns of use of five oral therapies among patients with mRCC diagnosed in 2006-2015, with claims through 2016. Patients were required to have 12 months of continuous enrollment before metastatic index date. Log-Poisson models estimated unadjusted and adjusted risk ratios (RRs) for associations between patient characteristics and OAA use. In sensitivity analyses, we used a competing risk framework to estimate adjusted risk differences in OAA use. RESULTS Our population-based study of 713 patients demonstrated low (37%) OAA use during the first year after metastatic index date among both publicly and privately insured patients, with shifting patterns of use consistent with regulatory approvals over time. Compared with patients age 18-49 years, patients age 70-74 years were half likely to use OAAs (95% confidence limit [CL], 0.34 to 0.78) and patients age 801 years were 71% less likely to use OAAs (95% CL, 0.17 to 0.50). Patients with two comorbidities (RR, 0.73; 95% CL, 0.55 to 0.98) and those with 31 comorbidities (RR, 0.68; 95% CL, 0.50 to 0.91) were less likely to receive OAA than those without comorbidities. Patients with higher frailty also had lower OAA utilization (RR, 0.67; 95% CL, 0.52 to 0.85). CONCLUSION These findings suggest a need to better understand the system-level and provider-level drivers of OAA underuse, as well as OAA adherence and associated survival.
Reactive Oxygen Species Signaling in Response to Pathogens
Creators: name: Torres, M. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: The production of reactive oxygen species (ROS), via consumption of oxygen in a so-called oxidative burst, is one of the earliest cellular responses following successful pathogen recognition. Apoplastic generation of superoxide (O2−), or its dismutation product hydrogen peroxide (H2O2), has been
Separation of Arabidopsis Pollen Tetrads Is Regulated by QUARTET1, a Pectin Methylesterase Gene
Creators: name: Francis, K. E.
name: Copenhaver, G. P.
name: Lam, S. Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Arabidopsis (Arabidopsis thaliana) QUARTET (QRT) genes are required for pollen separation during normal floral development. In qrt mutants, the four products of microsporogenesis remain fused and pollen grains are released as tetrads. In Arabidopsis, tetrad analysis in qrt mutants has been used to map all five centromeres, easily distinguish sporophytic from gametophytic mutations, and accurately assess crossover interference. Using a combination of forward and reverse genetics, we have identified the gene responsible for the qrt1 phenotype. Annotation predicts that QRT1 encodes a pectin methylesterase (PME), and enzymatic assays of QRT1 expressed in Escherichia coli indicate that QRT1 has PME activity. Promoter and transcription analysis demonstrate QRT1 is expressed in anther tissues shortly after meiosis is complete. Unexpectedly, the QRT1 promoter is also active in a variety of developmentally unrelated tissues, including developing guard cells, the hypocotyl-root transition zone, areas of lateral root emergence, and floral nectaries. PMEs constitute a large gene family in Arabidopsis, are involved in cell wall loosening, and have been implicated in various aspects of floral development and pollen tube elongation. The identification of QRT1 as a PME contributes to our understanding of pollen development and may help to provide valuable genetic tools in other plant species.
«Ich bin auf das ‹Wohlwollen› der Schule angewiesen…» Eine Einzelfallanalyse mit dem Schwerpunkt «Inklusion von Kindern mit Trisomie 21 in der Schweizer Regelschule»
Creators: name: Pachlatko, Beat
Publisher: name: Zenodo
Year: 2023
Subjects: Sonderpädagogik
Masterarbeit
Trisomie 21
Regelschule

description: In dieser Arbeit wird mittels einer qualitativen Inhaltsanalyse ein Einzelfall untersucht, in welchem die Integration eines Kindes mit Trisomie 21 in der Schweizer Regelschule im Zentrum steht. In der durchgeführten qualitativen Einzelfallanalyse wird nach fördernden und hemmenden Faktoren innerhalb des Settings gesucht. Die Ergebnisse zeigen, dass die Haltung der Lehrperson, tradierte Strukturen und Vorstellungen von Schule sowie fehlende Ressourcen zentrale Bestandteile für ein Gelingen oder Scheitern von Inklusion in der Schule darstellen. Die Erkenntnisse werden in den Kontext der aktuellen Inklusionssituation der Schweiz gestellt und diskutiert. Aus der vorgelegten Arbeit lässt sich ableiten, dass in der Schweiz noch einige Herausforderungen hin zu einem inklusiven Bildungssystem zu bewältigen sind.
Additional file 2: of Itâ  s more than low BMI: prevalence of cachexia and associated mortality in COPD
Creators: name: Merry-Lynn McDonald
name: Wouters, Emiel
name: Rutten, Erica
name: Casaburi, Richard
name: Rennard, Stephen
name: Lomas, David
name: Bamman, Marcas
name: Bartolome Celli
name: Agusti, Alvar
name: Tal-Singer, Ruth
name: Hersh, Craig
name: Dransfield, Mark
name: Silverman, Edwin
Publisher: name: Figshare
Year: 2019
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: Computational Biology

description: Figure S2. Relationship between percent emphysema at baseline and Year 1 with cachexia and weight-loss. (PDF 5 kb)
Ein Zeuge Christi in der Kirche: Hans Urs von Balthasar
Creators: name: Lubac, Henri De
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 4 Nr. 5 (1975): Internationale katholische Zeitschrift Communio, Band 4, Heft 5
The impact of cosmic variance on simulating weak lensing surveys
Creators: name: Kannawadi, Arun
name: Mandelbaum, Rachel
name: Lackner, Claire
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Upcoming weak lensing surveys will survey large cosmological volumes to measure the growth of cosmological structure with time and thereby constrain dark energy. One major systematic uncertainty in this process is the calibration of the weak lensing shape distortions, or shears. Most upcoming surveys plan to test several aspects of their shear estimation algorithms using sophisticated image simulations that include realistic galaxy populations based on high-resolution data from the Hubble Space Telescope (HST). However, existing datasets from the (HST) cover very small cosmological volumes, so cosmic variance could cause the galaxy populations in them to be atypical. A narrow redshift slice from such surveys could be dominated by a single large overdensity or underdensity. In that case, the morphology-density relation could alter the local galaxy populations and yield an incorrect calibration of shear estimates as a function of redshift. We directly test this scenario using the COSMOS survey, the largest-area (HST) survey to date, and show how the statistical distributions of galaxy shapes and morphological parameters (e.g., Sérsic $n$) are influenced by redshift-dependent cosmic variance. The typical variation in RMS ellipticity due to environmental effects is 5 per cent (absolute, not relative) for redshift bins of width $Δz=0.05$, which could result in uncertain shear calibration at the 1 per cent level. We conclude that the cosmic variance effects are large enough to exceed the systematic error budget of future surveys, but can be mitigated with careful choice of training dataset and sufficiently large redshift binning.
description: 18 pages, 16 figures, 3 tables. v2 matches the accepted version for MNRAS
Position-dependent spin-orbit coupling for ultracold atoms
Creators: name: Su, S. -W.
name: Gou, S. -C.
name: Liu, I. -K.
name: Spielman, I. B.
name: Santos, L.
name: Acus, A.
name: Mekys, A.
name: Ruseckas, J.
name: Juzeliūnas, G.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Atomic Physics (physics.atom-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We theoretically explore atomic Bose-Einstein condensates (BECs) subject to position-dependent spin-orbit coupling (SOC). This SOC can be produced by cyclically laser coupling four internal atomic ground (or metastable) states in an environment where the detuning from resonance depends on position. The resulting spin-orbit coupled BEC phase-separates into domains, each of which contain density modulations - stripes - aligned either along the x or y direction. In each domain, the stripe orientation is determined by the sign of the local detuning. When these stripes have mismatched spatial periods along domain boundaries, non-trivial topological spin textures form at the interface, including skyrmions-like spin vortices and anti-vortices. In contrast to vortices present in conventional rotating BECs, these spin-vortices are stable topological defects that are not present in the corresponding homogenous stripe-phase spin-orbit coupled BECs.
Synergid Cell Death in Arabidopsis Is Triggered following Direct Interaction with the Pollen Tube
Creators: name: Drews, G. N.
name: Sandaklie-Nikolova, L.
name: Palanivelu, R.
name: Copenhaver, G. P.
name: King, E. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: During angiosperm reproduction, one of the two synergid cells within the female gametophyte undergoes cell death prior to fertilization. The pollen tube enters the female gametophyte by growing into the synergid cell that undergoes cell death and releases its two sperm cells within the degenerating synergid cytoplasm to effect double fertilization. In Arabidopsis (Arabidopsis thaliana) and many other species, synergid cell death is dependent upon pollination. However, the mechanism by which the pollen tube causes synergid cell death is not understood. As a first step toward understanding this mechanism, we defined the temporal relationship between pollen tube arrival at the female gametophyte and synergid cell death in Arabidopsis. Using confocal laser scanning microscopy, light microscopy, transmission electron microscopy, and real-time observation of these two events in vitro, we demonstrate that synergid cell death initiates after the pollen tube arrives at the female gametophyte but before pollen tube discharge. Our results support a model in which a signaling cascade triggered by pollen tube-synergid cell contact induces synergid cell death in Arabidopsis.
Evidence for non-universal scaling in dimension four Ising spin glasses
Creators: name: Lundow, P. H.
name: Campbell, I. A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: The critical behavior of the Binder cumulant for Ising spin glasses in dimension four are studied through simulation measurements. Data for the bimodal interaction model are compared with those for the Laplacian interaction model. Special attention is paid to scaling corrections. The limiting infinite size value at criticality for this dimensionless variable is a parameter characteristic of a universality class. This critical limit is estimated to be equal to $0.523(3)$ in the bimodal model and to $0.473(3)$ in the Laplacian model.
description: 4 pages, 4 figures
Correlations between light and heavy flavors near the chiral crossover
Creators: name: Sasaki, Chihiro
name: Redlich, Krzysztof
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Thermal fluctuations and correlations between the light and heavy-light mesons are explored within a chiral effective theory implementing heavy quark symmetry. We show, that various heavy-light flavor correlations indicate a remnant of the chiral criticality in a narrow range of temperature where the chiral susceptibility exhibits a peak structure. The onset of the chiral crossover, in the heavy-light flavor correlations, is therefore independent from the light flavors. This indicates that the fluctuations carried by strange charmed mesons can also be used to identify the chiral crossover, which is dominated by the non-strange light quark dynamics.
description: 6 pages, 4 figures; v2) references added, discussions expanded though the main statement unchanged
Real-World Utilization of Oral Anticancer Agents and Related Costs in Older Adults with Metastatic Renal Cell Carcinoma in the United States
Creators: name: Baggett, C.D.
name: George, D.
name: Zhang, T.
name: Greiner, M.A.
name: Pritchard, J.
name: Dinan, M.A.
name: Scales, C.D.
name: Wheeler, S.B.
name: Kaye, D.R.
name: Spees, L.P.
name: Wilson, L.E.
Publisher: name: IOS Press BV
Year: 2021

description: BACKGROUND: Substantial racial and socioeconomic disparities in metastatic RCC (mRCC) have persisted following the introduction of targeted oral anticancer agents (OAAs). The relationship between patient characteristics and OAA access and costs that may underlie persistent disparities in mRCC outcomes have not been examined in a nationally representative patient population. METHODS: Retrospective SEER-Medicare analysis of patients diagnosed with mRCC between 2007-2015 over age 65 with Medicare part D prescription drug coverage. Associations between patient characteristics, OAA receipt, and associated costs were analyzed in the 12 months following mRCC diagnosis and adjusted to 2015 dollars. RESULTS: 2,792 patients met inclusion criteria, of which 32.4%received an OAA. Most patients received sunitinib (57%) or pazopanib (28%) as their first oral therapy. Receipt of OAA did not differ by race/ethnicity or socioeconomic indicators. Patients of advanced age (>80 years), unmarried patients, and patients residing in the Southern US were less likely to receive OAAs. The mean inflation-adjusted 30-day cost to Medicare of a patient's first OAA prescription nearly doubled from $3864 in 2007 to $7482 in 2015, while patient out-of-pocket cost decreased from $2409 to $1477. CONCLUSION: Race, ethnicity, and socioeconomic status were not associated with decreased OAA receipt in patients with mRCC; however, residing in the Southern United States was, as was marital status. Surprisingly, the cost to Medicare of an initial OAA prescription nearly doubled from 2007 to 2015, while patient out-of-pocket costs decreased substantially. Shifts in OAA costs may have significant economic implications in the era of personalized medicine.
Bayesian analysis of the dynamic cosmic web in the SDSS galaxy survey
Creators: name: Leclercq, Florent
name: Jasche, Jens
name: Wandelt, Benjamin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Recent application of the Bayesian algorithm BORG to the Sloan Digital Sky Survey (SDSS) main sample galaxies resulted in the physical inference of the formation history of the observed large-scale structure from its origin to the present epoch. In this work, we use these inferences as inputs for a detailed probabilistic cosmic web-type analysis. To do so, we generate a large set of data-constrained realizations of the large-scale structure using a fast, fully non-linear gravitational model. We then perform a dynamic classification of the cosmic web into four distinct components (voids, sheets, filaments, and clusters) on the basis of the tidal field. Our inference framework automatically and self-consistently propagates typical observational uncertainties to web-type classification. As a result, this study produces accurate cosmographic classification of large-scale structure elements in the SDSS volume. By also providing the history of these structure maps, the approach allows an analysis of the origin and growth of the early traces of the cosmic web present in the initial density field and of the evolution of global quantities such as the volume and mass filling fractions of different structures. For the problem of web-type classification, the results described in this work constitute the first connection between theory and observations at non-linear scales including a physical model of structure formation and the demonstrated capability of uncertainty quantification. A connection between cosmology and information theory using real data also naturally emerges from our probabilistic approach. Our results constitute quantitative chrono-cosmography of the complex web-like patterns underlying the observed galaxy distribution.
description: 19 pages, 9 figures, 7 tables, matches JCAP published version
Die 32. Generalversammlung des Jesuitenordens
Creators: name: Haeffner, Gerd
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 4 Nr. 4 (1975): Internationale katholische Zeitschrift Communio, Band 4, Heft 4
Additional file 1: of Neurologic toxicity associated with immune checkpoint inhibitors: a pharmacovigilance study
Creators: name: Johnson, Douglas
name: Manouchehri, Ali
name: Haugh, Alexandra
name: Quach, Henry
name: Balko, Justin
name: Lebrun-Vignes, Benedicte
name: Mammen, Andrew
name: Moslehi, Javid
name: Joe-Elie Salem
Publisher: name: Figshare
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology

description: Table S1. Neuro-psychiatric adverse events grouping as a function of Medical Dictionary for Regulatory Activities (MedDRA) Classification Version 21.0. Table S2. Example of calculating reporting odds ratio (ROR) in Vigibase. Table S3. Clinical characteristics of patients with ICI-associated cerebral vasculitis collected from VigiBase. Table S4. Clinical characteristics of patients with ICI-associated myasthenia gravis collected from VigiBase. Table S5. Clinical characteristics of patients with ICI-associated encephalitis/myelitis collected from VigiBase. Table S6. Clinical characteristics of patients with ICI-associated Guillain-Barre Syndrome collected from VigiBase. Table S7. Clinical characteristics of patients with ICI-associated non-infectious meningitis collected from VigiBase. (DOCX 38 kb)
Tissue-Specific Expression Patterns of Arabidopsis NF-Y Transcription Factors Suggest Potential for Extensive Combinatorial Complexity
Creators: name: Tayrose, G.
name: Siefers, N.
name: Kumimoto, R. W.
name: Holt, B. F.
name: Bynum, W. E.
name: Dang, K. K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: All aspects of plant and animal development are controlled by complex networks of transcription factors. Transcription factors are essential for converting signaling inputs, such as changes in daylength, into complex gene regulatory outputs. While some transcription factors control gene expression by binding to cis-regulatory elements as individual subunits, others function in a combinatorial fashion. How individual subunits of combinatorial transcription factors are spatially and temporally deployed (e.g. expression-level, posttranslational modifications and subcellular localization) has profound effects on their control of gene expression. In the model plant Arabidopsis (Arabidopsis thaliana), we have identified 36 Nuclear Factor Y (NF-Y) transcription factor subunits (10 NF-YA, 13 NF-YB, and 13 NF-YC subunits) that can theoretically combine to form 1,690 unique complexes. Individual plant subunits have functions in flowering time, embryo maturation, and meristem development, but how they combine to control these processes is unknown. To assist in the process of defining unique NF-Y complexes, we have created promoter:β-glucuronidase fusion lines for all 36 Arabidopsis genes. Here, we show NF-Y expression patterns inferred from these promoter:β-glucuronidase lines for roots, light- versus dark-grown seedlings, rosettes, and flowers. Additionally, we review the phylogenetic relationships and examine protein alignments for each NF-Y subunit family. The results are discussed with a special emphasis on potential roles for NF-Y subunits in photoperiod-controlled flowering time.
The ULF wave foreshock boundary: Cluster observations
Creators: name: Andres, Nahuel
name: Meziane, Karim
name: Mazelle, Christian
name: Bertucci, Cesar
name: Gomez, Daniel
Publisher: name: arXiv
Year: 2014
Subjects: subject: Space Physics (physics.space-ph)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The interaction of backstreaming ions with the incoming solar wind in the upstream region of the bow shock gives rise to a number of plasma instabilities from which ultra-low frequency (ULF) waves can grow. Because of their finite growth rate, the ULF waves are spatially localized in the foreshock region. Previous studies have reported observational evidences of the existence of a ULF wave foreshock boundary, which geometrical characteristics are very sensitive to the interplanetary magnetic field (IMF) cone angle. The statistical properties of the ULF wave foreshock boundary is examined in detail using Cluster data. A new identification of the ULF wave foreshock boundary is presented using specific and accurate criterion for a precises determination of boundary crossings. The criterion is based on the degree of IMF rotation as Cluster crosses the boundary. The obtained ULF wave foreshock boundary is compared with previous results reported in the literature as well as with theoretical predictions. Also, we examined the possible connexion between the foreshock boundary properties and the ion emission mechanisms at the bow shock.
AMALIY PRAGMATIKA: MUAMMO VA YECHIMLAR
Creators: name: Sattorova, Feruza
Publisher: name: Zenodo
Year: 2023

description: Ushbu maqola chet tili o'qitish ta'limida hozirgi paytdagi dolzarb muammolardan biri bo'lgan o'zga tilda samarali muloqot olib borishdagi mavjud muammolar va ularga amaliy pragmatika doirasida muallif tomonidan taklif qilingan ayrim mulohazalarga bag'ishlangan. Shuni ta'kidlash joizki, kommunikativ qobilyatda lisoniy bilimlardan tashqari pragmatik, sotsiopragmatik va strategik qobilyatni shakllantiruvchi bilimlar ahamiyatlidir.
An analogue of a theorem of Kurzweil
Creators: name: Simmons, David
Publisher: name: arXiv
Year: 2014
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: A theorem of Kurzweil ('55) on inhomogeneous Diophantine approximation states that if $θ$ is an irrational number, then the following are equivalent: (A) for every decreasing positive function $ψ$ such that $\sum_{q = 1}^\infty ψ(q) = \infty$, and for almost every $s\in\mathbb R$, there exist infinitely many $q\in\mathbb N$ such that $\|qθ- s\| < ψ(q)$, and (B) $θ$ is badly approximable. This theorem is not true if one adds to condition (A) the hypothesis that the function $q\mapsto qψ(q)$ is decreasing. In this paper we find a condition on the continued fraction expansion of $θ$ which is equivalent to the modified version of condition (A). This expands on a recent paper of D. H. Kim ('14).
Hexagonal Projected Symmetries
Creators: name: Oliveira, Juliane F.
name: Castro, Sofia S. B. S. D.
name: Labouriau, Isabel S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Group Theory (math.GR)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics

description: In the study of pattern formation in symmetric physical systems a 3-dimensional structure in thin domains is often modelled as 2-dimensional one. We are concerned with functions in $R^3$ that are invariant under the action of a crystallographic group and the symmetries of their projections into a function defined on a plane. We obtain a list of the crystallographic groups for which the projected functions have a hexagonal lattice of periods. The proof is constructive and the result may be used in the study of observed patterns in thin domains, whose symmetries are not expected in 2-dimensional models, like the black-eye pattern.
description: corrected initials of second author
Additional file 1: of Rationale and protocol of the ENGAGE study: a double-blind randomized controlled preference trial using a comprehensive cohort design to measure the effect of a cognitive and leisure-based intervention in older adults with a memory complaint
Creators: name: S. Belleville
name: A. Moussard
name: A. Ansaldo
name: P. Belchior
name: L. Bherer
name: N. Bier
name: V. Bohbot
name: M.-A. Bruneau
name: L. Cuddy
name: B. Gilbert
name: R. Jokel
name: K. Mahalingam
name: K. McGilton
name: K. Murphy
name: G. Naglie
name: E. Rochon
name: A. Troyer
name: N. Anderson
Publisher: name: Figshare
Year: 2019
Subjects: subject: Neuroscience
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: SPIRIT 2013 checklist: recommended items to address in a clinical trial protocol and related documents. (DOC 122 kb)
Abscisic Acid Receptors
Creators: name: Kline, K. G.
name: Sussman, M. R.
name: Jones, A. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Abscisic acid (ABA), a sesquiterpenoid phytohormone, was first discovered in the 1960s, and has since been found to be a key regulator of such diverse processes as dormancy, germination, seed development, and responses to biotic and abiotic stress ([Cutler et al., 2010][1]). Since the discovery of
Rapid Auxin-Induced Cell Expansion and Gene Expression: A Four-Decade-Old Question Revisited
Creators: name: Jones, A.
name: Luthen, H.
name: Schenck, D.
name: Christian, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The classical effect of the plant hormone auxin is very rapid stimulation of cell expansion followed by sustained growth over a longer time period. However, auxins are also important in other responses, such as cell division and differentiation. Recently, the TRANSPORT INHIBITOR RESPONSE1/AUXIN-
Associations of tobacco retailer availability with chronic obstructive pulmonary disease related hospital outcomes, United States, 2014
Creators: name: Baggett, C.D.
name: Gottfredson, N.C.
name: Golden, S.D.
name: Kong, A.Y.
name: Ribisl, K.M.
name: Delamater, P.L.
Publisher: name: Elsevier Ltd
Year: 2021

description: There are associations between tobacco retailer density and smoking behaviors, but little is known about whether places with more tobacco retailers have more smoking-related health problems. Using cross-sectional data from 2014, we investigated the relationships between tobacco retailer density and chronic obstructive pulmonary disease (COPD) related outcomes in a sample of 1510 counties across the United States. Higher retailer density was associated with a 19% (IRR, 1.19; 95% CI, 1.12–1.27) higher COPD-related hospital discharge rate and 30% (IRR, 1.30; 95% CI 1.21–1.39) higher total COPD-related hospital costs per population. The tobacco retailer environment may be an important target for reducing smoking-related health burdens and costs.
The Perception of Cytokinin: A Story 50 Years in the Making
Creators: name: Kieber, J. J.
name: Schaller, G. E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: In 1913, Gottlieb Haberlandt found that phloem exudates from various plant species had the ability to stimulate cell division in wounded potato ( Solanum tuberosum ) tubers ([Haberlandt, 1913][1]). These studies implied the existence of a soluble factor(s) that could promote cell division in plant
Nonsingular Decaying Vacuum Cosmology and Entropy Production
Creators: name: Lima, J. A. S.
name: Basilakos, S.
name: Solà, Joan
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The thermodynamic behavior of a decaying vacuum cosmology describing the entire cosmological history evolving between two extreme (early and late time) de Sitter eras is investigated. The thermal evolution from the early de Sitter to the radiation phase is discussed in detail. The temperature evolution law and the increasing entropy function are analytically determined. The entropy of the effectively massless particles is initially zero but evolves continuously to the present day maximum value within the current Hubble radius, $S_0 \sim 10^{88}$ in natural units. By using the Gibbons-Hawking temperature relation for the de Sitter spacetime, it is found that the ratio between the primeval and the late time vacuum energy densities is $ρ_{vI}/ρ_{v0} \sim 10^{123}$, as required by some naive estimates from quantum field theory.
description: 12 pages in free style (some discussion added in the conclusions), 2 figures, accepted for publication in General Relativity and Gravitation