cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of An exploration of registered dietitian accreditation system development in China
Creators: name: Yajie, Zhang
name: Xiaoli, Wang
name: Ya, Liu
name: Xiuhua, Shen
name: Rong, Xiao
name: Huilian, Zhu
name: Guo, Zeng
name: Wei, Cai
name: Aiguo, Ma
name: Yuexin, Yang
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Science Policy

description: Supplementary Material 1
Burgen- und Fremdenverkehr
Creators: name: Günther, Erich
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2017

description: -
description: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 1, Nr. 1 (1960): Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
A general multiparameter version of Gnedenko's transfer theorem
Creators: name: Kern, Peter
Publisher: name: arXiv
Year: 2012
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60F05, 60B10 (Primary) 60B12, 60B15, 60G60 (Secondary)

description: Limit theorems for a random number of independent random variables are frequently called transfer theorems. Investigations into this direction for sums of random variables with independent random sample size have been originated by Gnedenko. We present a widely applicable transfer theorem for random variables on a general metric space with random multiparameters instead of random sample sizes. This summarizes an intrinsic principle behind the transfer type results known from the literature.
Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis.
Creators: name: Kearney, Alison L
name: Norris, Dougall M
name: Ghomlaghi, Milad
name: Kin Lok Wong, Martin
name: Humphrey, Sean J
name: Carroll, Luke
name: Yang, Guang
name: Cooke, Kristen C
name: Yang, Pengyi
name: Geddes, Thomas A
name: Shin, Sungyoung
name: Fazakerley, Daniel J
name: Nguyen, Lan K
name: James, David E
name: Burchfield, James G
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Human
Insulin
Cell biology
Phosphorylation
Signal transduction
Mouse
Plasma membrane
systems biology
computational biology
PI3K
AKT

description: The phosphoinositide 3-kinase (PI3K)-Akt network is tightly controlled by feedback mechanisms that regulate signal flow and ensure signal fidelity. A rapid overshoot in insulin-stimulated recruitment of Akt to the plasma membrane has previously been reported, which is indicative of negative feedback operating on acute timescales. Here, we show that Akt itself engages this negative feedback by phosphorylating insulin receptor substrate (IRS) 1 and 2 on a number of residues. Phosphorylation results in the depletion of plasma membrane-localised IRS1/2, reducing the pool available for interaction with the insulin receptor. Together these events limit plasma membrane-associated PI3K and phosphatidylinositol (3,4,5)-trisphosphate (PIP3) synthesis. We identified two Akt-dependent phosphorylation sites in IRS2 at S306 (S303 in mouse) and S577 (S573 in mouse) that are key drivers of this negative feedback. These findings establish a novel mechanism by which the kinase Akt acutely controls PIP3 abundance, through post-translational modification of the IRS scaffold.
Melting of hexagonal Skyrmion states in chiral magnets
Creators: name: Ambrose, Matthew
name: Stamps, Robert
Publisher: name: arXiv
Year: 2012
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Skyrmions are spiral structures observed in thin films of certain magnetic materials (10.1126/science.1120639). Of the phases allowed by the crystalline symmetries of these materials(10.1103/PhysRevB.80.054416) only the hexagonally packed phases (SC_h) has been observed. Here the melting of the $SC_h$ phase is investigated using Monte Carlo simulations. In addition to the usual measure of Skyrmion density chiral charge, a morphological measure is considered. In doing so it is shown that the low temperature reduction in chiral charge is associated with a change in Skyrmion profiles rather than Skyrmion destruction. At higher temperatures the loss of six fold symmetry is associated with the appearance of elongated Skyrmions that disrupt the hexagonal packing.
description: 15 pages, 10 figures
Neuentdeckte Fresken auf Burg Lichtenberg
Creators: name: Schmidt, Richard
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2017

description: -
description: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 1, Nr. 2 (1960): Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
Material processing conditions effect on the thermokinetics of end of life tyres
Creators: name: Al-Salem, Sultan Majed
name: Karam, Hajar Jawad
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: In this work, end of life tyres (ELTs) samples were subjected to pyrolysis in a dynamic thermogravimetry set-up under various heating rates between 5°C and 25°C min−1. The experimental design involved dried and non-dried sample results in an isothermal step within the heating program, to be able to compare the data against non-dried samples, to further investigate the effect of drying on the results obtained. The drying of the samples resulted in an increase in the onset temperature by some 30°C. However, cryomilling the ELTs samples showed a great effect in reducing the onset of the degradation curve by about 10°C amongst the same set of experiments. The type of sample, in terms of size and processing/milling condition, had a significant impact on the heat flow properties and calorimetry reported. The exothermic region for the original shavings resulted in an enthalpy of −48 J g−1, whilst the cutting mill samples exhibited an enthalpy increase to −184 J g−1. However, the cryomilled samples showed an enthalpy increase estimated at 139 J g−1.
Patterns of within-host genetic diversity in SARS-CoV-2
Creators: name: Tonkin-Hill, Gerry
name: Martincorena, Inigo
name: Amato, Roberto
name: Lawson, Andrew RJ
name: Gerstrung, Moritz
name: Johnston, Ian
name: Jackson, David K
name: Park, Naomi
name: Lensing, Stefanie V
name: Quail, Michael A
name: Gonçalves, Sonia
name: Ariani, Cristina
name: Spencer Chapman, Michael
name: Hamilton, William L
name: Meredith, Luke W
name: Hall, Grant
name: Jahun, Aminu S
name: Chaudhry, Yasmin
name: Hosmillo, Myra
name: Pinckert, Malte L
name: Georgana, Iliana
name: Yakovleva, Anna
name: Caller, Laura G
name: Caddy, Sarah L
name: Feltwell, Theresa
name: Khokhar, Fahad A
name: Houldcroft, Charlotte J
name: Curran, Martin D
name: Parmar, Surendra
name: The COVID-19 Genomics UK (COG-UK) Consortium
name: Alderton, Alex
name: Nelson, Rachel
name: Harrison, Ewan M
name: Sillitoe, John
name: Bentley, Stephen D
name: Barrett, Jeffrey C
name: Torok, M Estee
name: Goodfellow, Ian G
name: Langford, Cordelia
name: Kwiatowski, Dominic P
name: Wellcome Sanger Institute COVID-19 Surveillance Team
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Research Article
Epidemiology and Global Health
Genetics and Genomics
SARS-CoV-2
within-host
mutational spectrum
transmission
Other

description: Funder: COG-UK
description: Funder: Medical Research Council; FundRef: http://dx.doi.org/10.13039/501100000265
description: Funder: NIHR; FundRef: http://dx.doi.org/10.13039/501100000272
description: Funder: Wellcome; FundRef: http://dx.doi.org/10.13039/100004440
description: Monitoring the spread of SARS-CoV-2 and reconstructing transmission chains has become a major public health focus for many governments around the world. The modest mutation rate and rapid transmission of SARS-CoV-2 prevents the reconstruction of transmission chains from consensus genome sequences, but within-host genetic diversity could theoretically help identify close contacts. Here we describe the patterns of within-host diversity in 1181 SARS-CoV-2 samples sequenced to high depth in duplicate. 95.1% of samples show within-host mutations at detectable allele frequencies. Analyses of the mutational spectra revealed strong strand asymmetries suggestive of damage or RNA editing of the plus strand, rather than replication errors, dominating the accumulation of mutations during the SARS-CoV-2 pandemic. Within- and between-host diversity show strong purifying selection, particularly against nonsense mutations. Recurrent within-host mutations, many of which coincide with known phylogenetic homoplasies, display a spectrum and patterns of purifying selection more suggestive of mutational hotspots than recombination or convergent evolution. While allele frequencies suggest that most samples result from infection by a single lineage, we identify multiple putative examples of co-infection. Integrating these results into an epidemiological inference framework, we find that while sharing of within-host variants between samples could help the reconstruction of transmission chains, mutational hotspots and rare cases of superinfection can confound these analyses.
Romanische Mauerwerkstechnik auf fränkischen Burgen
Creators: name: Leistikow, Dankwart
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2017

description: -
description: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 1, Nr. 2 (1960): Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
Diversity and Paleodemography of the Addax ( Addax nasomaculatus ), a Saharan Antelope on the Verge of Extinction
Creators: name: Hempel, Elisabeth
name: Westbury, Michael V.
name: Grau, José H.
name: Trinks, Alexandra
name: Paijmans, Johanna L. A.
name: Kliver, Sergei
name: Barlow, Axel
name: Mayer, Frieder
name: Müller, Johannes
name: Chen, Lei
name: Koepfli, Klaus-Peter
name: Hofreiter, Michael
name: Bibi, Faysal
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Addax nasomaculatus
antelope
archival DNA
bovid
conservation
critically endangered
genome assembly
museum collections
PSMC

description: Since the 19th century, the addax (Addax nasomaculatus) has lost approximately 99% of its former range. Along with its close relatives, the blue antelope (Hippotragus leucophaeus) and the scimitar-horned oryx (Oryx dammah), the addax may be the third large African mammal species to go extinct in the wild in recent times. Despite this, the evolutionary history of this critically endangered species remains virtually unknown. To gain insight into the population history of the addax, we used hybridization capture to generate ten complete mitochondrial genomes from historical samples and assembled a nuclear genome. We found that both mitochondrial and nuclear diversity are low compared to other African bovids. Analysis of mitochondrial genomes revealed a most recent common ancestor ~32 kya (95% CI 11–58 kya) and weak phylogeographic structure, indicating that the addax likely existed as a highly mobile, panmictic population across its Sahelo–Saharan range in the past. PSMC analysis revealed a continuous decline in effective population size since ~2 Ma, with short intermediate increases at ~500 and ~44 kya. Our results suggest that the addax went through a major bottleneck in the Late Pleistocene, remaining at low population size prior to the human disturbances of the last few centuries.
Effect of butanol additive with mango seed biodiesel and diesel ternary blends on performance and emission characteristics of diesel engine
Creators: name: Ahmad, Khurshid
name: Saini, Prashant
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Current research investigates performance and emission characteristics of single cylinder 4-S diesel engine powered by different ternary fuel blends of diesel, mango seed (potential renewable feedstock of energy generation) biodiesel (MSB) and butanol (promising, sustainable, renewable and eco-friendly) oxygenated additive at different loading conditions experimentally. For the purpose, oil is extracted from discarded mango seeds through Soxhlet apparatus and biodiesel is prepared through transesterification process. Different blending mixture of MSB (fixed in 20%), diesel (80%, 75%, 70%, and 65%) and butanol (0%, 5%, 10%, and 15%) additive on their volume basis are prepared through magnetic stirring. These blends are named as MSB20B0, MSB20B5, MSB20B10, and MSB20B15, respectively. Experiment reveals that MSB20B5 lowers the BSFC by 25.79% and increases the BTE by 8.46% in comparison to MSB20B0 at maximum loading and approaching diesel fuel. In addition, MSB20B5 blend reduces the exhaust pollutants such as HC, NOx, CO2, and CO by 9.16%, 17.74%, 9.92%, and 13.33%, respectively, compared to MSB20B0 biodiesel blend at maximum loading. Overall, MSB20B5 ternary blend improves engine performance and reduce emissions hence recommended for diesels.
Decreased Fatty Acid Transporter FABP1 and Increased Isoprostanes and Neuroprostanes in the Human Term Placenta: Implications for Inflammation and Birth Weight in Maternal Pre-Gestational Obesity
Creators: name: Belcastro, Livia
name: Ferreira, Carolina S.
name: Saraiva, Marcelle A.
name: Mucci, Daniela B.
name: Murgia, Antonio
name: Lai, Carla
name: Vigor, Claire
name: Oger, Camille
name: Galano, Jean-Marie
name: Pinto, Gabriela D. A.
name: Griffin, Julian L.
name: Torres, Alexandre G.
name: Durand, Thierry
name: Burton, Graham J.
name: Sardinha, Fátima L. C.
name: El-Bacha, Tatiana
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: maternal pre-gestational obesity
placenta
lipid metabolism
fatty acid transporter proteins
isoprostanoids
neuroprostanes
isoprostanes
docosahexaenoic acid
arachidonic acid

description: The rise in prevalence of obesity in women of reproductive age in developed and developing countries might propagate intergenerational cycles of detrimental effects on metabolic health. Placental lipid metabolism is disrupted by maternal obesity, which possibly affects the life-long health of the offspring. Here, we investigated placental lipid metabolism in women with pre-gestational obesity as a sole pregnancy complication and compared it to placental responses of lean women. Open profile and targeted lipidomics were used to assess placental lipids and oxidised products of docosahexaenoic (DHA) and arachidonic acid (AA), respectively, neuroprostanes and isoprostanes. Despite no overall signs of lipid accumulation, DHA and AA levels in placentas from obese women were, respectively, 2.2 and 2.5 times higher than those from lean women. Additionally, a 2-fold increase in DHA-derived neuroprostanes and a 1.7-fold increase in AA-derived isoprostanes were seen in the obese group. These changes correlated with a 70% decrease in placental FABP1 protein. Multivariate analyses suggested that neuroprostanes and isoprostanes are associated with maternal and placental inflammation and with birth weight. These results might shed light on the molecular mechanisms associated with altered placental fatty acid metabolism in maternal pre-gestational obesity, placing these oxidised fatty acids as novel mediators of placental function.
Accurate eigenvalue decomposition of arrowhead matrices and applications
Creators: name: Stor, Nevena Jakovcevic
name: Slapnicar, Ivan
name: Barlow, Jesse L.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 65F15

description: We present a new algorithm for solving an eigenvalue problem for a real symmetric arrowhead matrix. The algorithm computes all eigenvalues and all components of the corresponding eigenvectors with high relative accuracy in $O(n^{2})$ operations. The algorithm is based on a shift-and-invert approach. Double precision is eventually needed to compute only one element of the inverse of the shifted matrix. Each eigenvalue and the corresponding eigenvector can be computed separately, which makes the algorithm adaptable for parallel computing. Our results extend to Hermitian arrowhead matrices, real symmetric diagonal-plus-rank-one matrices and singular value decomposition of real triangular arrowhead matrices.
Additional file 1 of Mitochondria-targeted nanoplatforms for enhanced photodynamic therapy against hypoxia tumor
Creators: name: Wen, Jiexin
name: Luo, Yong
name: Gao, Hui
name: Zhang, Liang
name: Wang, Xiang
name: Huang, Ju
name: Shang, Tingting
name: Zhou, Di
name: Wang, Dong
name: Wang, Zhigang
name: Li, Pan
name: Wang, Zhaoxia
Publisher: name: figshare
Year: 2021
Subjects: Biochemistry
Space Science
Medicine
Cell Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Cancer

description: Additional file 1: Fig. S1. Characterizations of 3BP@PLGA. Fig. S2. (a) UV–vis-NIR absorbance spectra of IR780 at elevated concentrations. (b) The relative absorbance of IR780 in the UV–vis spectrum at 789 nm. Fig. S3. (a) UV–vis-NIR absorbance spectra of 3BP at elevated concentrations. (b) The relative absorbance of 3BP in the UV–vis spectrum at 326 nm. Fig. S4. UV–vis-NIR absorbance spectra of 3BP@PLGA-IR780 and 3BP@PLGA. Fig. S5. Photo-stability study of 3BP@PLGA-IR780. Fig. S6. CLSM images of intracellular uptake of 3BP@PLGA-IR780 and 3BP@PLGA for MCF-7 and MBA-MD-231 cells. Fig. S7. (a) ATP standard curve and (b) ATP concentrations after different treatments. Fig. S8. Pharmacokinetics Study of 3BP@PLGA-IR780. Fig. S9. Ex vivo fluorescence imaging pictures of isolated tumors at 1, 3, 5, 7 and 10 days after intravenous injection of 3BP@PLGA-IR780. Fig. S10. PA signal changes of 3BP@PLGA-IR780 with PA laser excitation wavelengths ranging from 680 to 970 nm. Fig. S11. Representative tumor temperature change curve when receiving PDT (1.0 W cm−2, on 40 s, off to room temperature, 15 cycles). Fig. S12. Body-weight curves of six groups after various treatments. Fig. S13. H&E staining of the major organs of 4T1 tumor-bearing mice after different treatments. Fig. S14. (a) Hematological and blood biochemistry analysis of healthy mice after intravenous injection of 3BP@PLGA-IR780. (b) H&E staining of major organs of mice post injection of 3BP@PLGA-IR780.
Significance of the Gut Microbiome for Viral Diarrheal and Extra-Intestinal Diseases
Creators: name: Desselberger, Ulrich
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: gut microbiome
microbiome–host relationship
antiviral immune responses
gut disease
noninfectious disease
microbial metabolites
microbiome transplantation
probiotics
prebiotics
diet

description: The composition of the mammalian gut microbiome is very important for the health and disease of the host. Significant correlations of particular gut microbiota with host immune responsiveness and various infectious and noninfectious host conditions, such as chronic enteric infections, type 2 diabetes, obesity, asthma, and neurological diseases, have been uncovered. Recently, research has moved on to exploring the causalities of such relationships. The metabolites of gut microbiota and those of the host are considered in a ‘holobiontic’ way. It turns out that the host’s diet is a major determinant of the composition of the gut microbiome and its metabolites. Animal models of bacterial and viral intestinal infections have been developed to explore the interrelationships of diet, gut microbiome, and health/disease phenotypes of the host. Dietary fibers can act as prebiotics, and certain bacterial species support the host’s wellbeing as probiotics. In cases of Clostridioides difficile-associated antibiotic-resistant chronic diarrhea, transplantation of fecal microbiomes has sometimes cured the disease. Future research will concentrate on the definition of microbial/host/diet interrelationships which will inform rationales for improving host conditions, in particular in relation to optimization of immune responses to childhood vaccines.
Arndt Hartung - Walter Hartung Pfälzer Klosterbrevier
Creators: name: Avenarius, Wilhelm
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2017

description: Rezension zu: Arndt Hartung — Walter Hartung. Pfälzer Klosterbrevier
Aufbaustudien von Architekt Arndt Hartung mit einer geschichtlichen Skizze von Dr. Ing. Walter Hartung. Ludwigshafen 1984 (zu beziehen durch Dr. Walter Hartung, Parkstr. 56, 6700 Ludwigshafen), 79 Seiten, zahlreiche Abbildungen, eine Karte
description: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 26, Nr. 2 (1985): Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
Inhalt des Heftes 1987/I
Creators: name: Redaktion, Die
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2017

description: -
description: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 28, Nr. 1 (1987): Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Structure and Thermodynamical Properties of Zirconium hydrides from first-principle
Creators: name: Blomqvist, Jakob
name: Olofsson, Johan
name: Alvarez, Anna-Maria
name: Bjerkén, Christina
Publisher: name: arXiv
Year: 2012
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Zirconium alloys are used as nuclear fuel cladding material due to their mechanical and corrosion resistant properties together with their favorable cross-section for neutron scattering. At running conditions, however, there will be an increase of hydrogen in the vicinity of the cladding surface at the water side of the fuel. The hydrogen will diffuse into the cladding material and at certain conditions, such as lower temperatures and external load, hydrides will precipitate out in the material and cause well known embrittlement, blistering and other unwanted effects. Using phase-field methods it is now possible to model precipitation build-up in metals, for example as a function of hydrogen concentration, temperature and external load, but the technique relies on input of parameters, such as the formation energy of the hydrides and matrix. To that end, we have computed, using the density functional theory (DFT) code GPAW, the latent heat of fusion as well as solved the crystal structure for three zirconium hydride polymorphs: δ-ZrH1.6, γ-ZrH, and ε-ZrH2.
description: 9 pages, 9 figures, 15th Int. Conf. Environmental Degradation of Materials in Nuclear Power Systems-water reactors Uses graficx, subfigure, threeparttable (2012)
Merians Insektenbuch. Zum Umdruckexemplar der Bibliothek des Germanischen Nationalmuseums
Creators: name: Pommeranz, Johannes
Publisher: name: KulturGut : aus der Forschung des Germanischen Nationalmuseums
Year: 2017

description: KulturGut : aus der Forschung des Germanischen Nationalmuseums, Nr. 55 (2017): KulturGut: aus der Forschung des Germanischen Nationalmuseums
Fully automated closed-loop glucose control compared with standard insulin therapy in adults with type 2 diabetes requiring dialysis: an open-label, randomized crossover trial
Creators: name: Boughton, Charlotte K.
name: Tripyla, Afroditi
name: Hartnell, Sara
name: Daly, Aideen
name: Herzig, David
name: Wilinska, Malgorzata E.
name: Czerlau, Cecilia
name: Fry, Andrew
name: Bally, Lia
name: Hovorka, Roman
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Article
/692/163/2743/137/773
/692/699/1585/104/1586
article

description: Funder: CB was supported by a grant from The Novo Nordisk UK Research Foundation
description: Funder: LB was supported by a grant of the Swiss Society for Endocrinology and a grant of the Diabetes and Swiss Kidney Foundation.
description: Funder: Supported by National Institute for Health Research Cambridge Biomedical Research Centre.
description: Abstract: We evaluated the safety and efficacy of fully closed-loop insulin therapy compared with standard insulin therapy in adults with type 2 diabetes requiring dialysis. In an open-label, multinational, two-center, randomized crossover trial, 26 adults with type 2 diabetes requiring dialysis (17 men, 9 women, average age 68 ± 11 years (mean ± s.d.), diabetes duration of 20 ± 10 years) underwent two 20-day periods of unrestricted living, comparing the Cambridge fully closed-loop system using faster insulin aspart (‘closed-loop’) with standard insulin therapy and a masked continuous glucose monitor (‘control’) in random order. The primary endpoint was time in target glucose range (5.6–10.0 mmol l−1). Thirteen participants received closed-loop first and thirteen received control therapy first. The proportion of time in target glucose range (5.6–10.0 mmol l−1; primary endpoint) was 52.8 ± 12.5% with closed-loop versus 37.7 ± 20.5% with control; mean difference, 15.1 percentage points (95% CI 8.0–22.2; P < 0.001). Mean glucose was lower with closed-loop than control (10.1 ± 1.3 versus 11.6 ± 2.8 mmol l−1; P = 0.003). Time in hypoglycemia (<3.9 mmol l−1) was reduced with closed-loop versus control (median (IQR) 0.1 (0.0–0.4%) versus 0.2 (0.0–0.9%); P = 0.040). No severe hypoglycemia events occurred during the control period, whereas one severe hypoglycemic event occurred during the closed-loop period, but not during closed-loop operation. Fully closed-loop improved glucose control and reduced hypoglycemia compared with standard insulin therapy in adult outpatients with type 2 diabetes requiring dialysis. The trial registration number is NCT04025775.
Additional file 1 of Quantifying implementation strategy and dissemination channel preferences and experiences for pain management in primary care: a novel implementer-reported outcome
Creators: name: Ashcraft, Laura Ellen
name: Moon, Deborah J.
name: Merlin, Jessica S.
name: Eack, Shaun M.
name: Rogal, Shari S.
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1.
Additional file 2 of Quantifying implementation strategy and dissemination channel preferences and experiences for pain management in primary care: a novel implementer-reported outcome
Creators: name: Ashcraft, Laura Ellen
name: Moon, Deborah J.
name: Merlin, Jessica S.
name: Eack, Shaun M.
name: Rogal, Shari S.
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2.
title: Attitudes towards Megan's Law and juvenile sex offenders
Creators: name: Cochrane, Debra Lee
Publisher: name: University of Nevada, Las Vegas
Year: 2010

description: Sex offender registration laws are very controversial. All fifty states require adult sex offenders to register. Twenty-eight states have extended registration and community notification requirements to juveniles (Hiller, 1998). These states seem to have failed to look at the uniqueness of juvenile sex offending. Juveniles have a very low recidivism rate and complex issues of culpability from age-of-consent laws. Applying Megan's Law to juveniles could have considerable negative consequences for juveniles' social development, particularly because one of the main stipulations of the law requires the juvenile to notify their school. Rehabilitation is a key factor of the juvenile justice system and by applying Megan's Law to juveniles it requires them to notify their school upon arrival, which adds to the juveniles' reputation, causes social isolation, and labels offenders as a sexual predator (Lowe, 1997). School is and important part of a child's development as they experience social interaction as well as basic learning skills. Therefore this type of notification is damaging the juveniles' chance to rehabilitate. This research study focused on general knowledge of and attitudes toward Megan's Law and its application to juvenile sex offenders among students currently attending the University of Nevada, Las Vegas. Participants' attitudes were compared to the underlying tenets conveyed in current legislation known as Megan's Law and recently enacted Adam Walsh Act of 2006.
On the quasi-isometric classification of locally compact groups
Creators: name: Cornulier, Yves
Publisher: name: arXiv
Year: 2012
Subjects: subject: Group Theory (math.GR)
subject: Geometric Topology (math.GT)
subject: Metric Geometry (math.MG)
subject: FOS: Mathematics
subject: Primary 20F67, Secondary 05C63, 20E08, 22D05, 43A07, 53C30, 53C35, 57S30

description: This (quasi-)survey addresses the quasi-isometry classification of locally compact groups, with an emphasis on amenable hyperbolic locally compact groups. This encompasses the problem of quasi-isometry classification of homogeneous negatively curved manifolds. A main conjecture provides a general description; an extended discussion reduces this conjecture to more specific statements. In the course of the paper, we provide statements of quasi-isometric rigidity for general symmetric spaces of noncompact type and also discuss accessibility issues in the realm of compactly generated locally compact groups.
description: 51 pages, 2 figures. v1->v2: significantly expanded version. The title has been changed; v2->v3: added Sections 4I and 5B [now 19.4.9 and 19.5.2]; v3->v4: renumbering of sections and theorems so as to fit with published version
The nature of the near-infrared interline sky background using fibre Bragg grating OH suppression
Creators: name: Trinh, Christopher Q.
name: Ellis, Simon C.
name: Bland-Hawthorn, Joss
name: Horton, Anthony J.
name: Lawrence, Jon S.
name: Leon-Saval, Sergio G.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: We analyse the near-infrared interline sky background, OH and O2 emission in 19 hours of H band observations with the GNOSIS OH suppression unit and the IRIS2 spectrograph at the 3.9-m AAT. We find that the temporal behaviour of OH emission is best described by a gradual decrease during the first half of the night followed by a gradual increase during the second half of the night following the behaviour of the solar elevation angle. We measure the interline background at 1.520 microns where the instrumental thermal background is very low and study its variation with zenith distance, time after sunset, ecliptic latitude, lunar zenith angle and lunar distance to determine the presence of non-thermal atmospheric emission, zodiacal scattered light and scattered moonlight. Zodiacal scattered light is too faint to be detected in the summed observations. Scattered moonlight due to Mie scattering by atmospheric aerosols is seen at small lunar distances (< 11 deg), but is otherwise too faint to detect. Except at very small lunar distances the interline background at a resolving power of R~2400 when using OH suppression fibres is dominated by a non-thermal atmospheric source with a temporal behaviour that resembles atmospheric OH emission suggesting that the interline background contains instrumentally-scattered OH. However, the interline background dims more rapidly than OH early in the night suggesting contributions from rapid dimming molecules. The absolute interline background is 560 +/- 120 photons s^-1 m^-2 micron^-1 arcsec^-2 under dark conditions. This value is similar to previous measurements without OH suppression suggesting that non-suppressed atmospheric emission is responsible for the interline background. Future OH suppression fibre designs may address this by the suppression of more sky lines using more accurate sky line measurements taken from high resolution spectra.
description: 17 pages, 12 figures, submitted to MNRAS
THE DETERMINANTS OF ORGANIZATIONAL PERFORMANCE: A CONCEPTUAL FRAMEWORK BASED ON THE BUSINESS INTELLIGENCE (STUDY OF JORDANIAN UNIVERSITIES)
Creators: name: AUDEH ALLEIMOUN
name: MOHAMAD ROSNI OTHMAN
name: MOHAMAD SAIFUL IZWAAN
Publisher: name: Zenodo
Year: 2023
Subjects: Entrepreneurial Orientation, Business Intelligence, Organizational Performance, Universities.

description: Abstract
In today's hypercompetitive business environment, to be competitive in continuously and rapidly changing markets, organizations must maximize their flexibility and capabilities. In order for organizations to survive and thrive in today's markets, they must embrace effective methods and practices Recreating their markets and identifying new opportunities is key to their success. This research contributes to the growing body of literature on Identifying crucial factors determining organizational performance. In this study, key research findings are synthesized in business intelligence, entrepreneurial orientation, a conceptual model is proposed that depicts Organizational performance can be enhanced by focusing on these factors in today's turbulent business environment. It attempts to in order to gain a better understanding of the potential mediating role of the aforementioned fields; we need to synthesize the knowledge of the aforementioned fields Learning within an organization.
Bergfried - Berchfrit. Wort und Begriff
Creators: name: Freier, Walter
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2017

description: -
description: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 1, Nr. 1 (1960): Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
The vector BPS baby Skyrme model
Creators: name: Adam, C.
name: Naya, C.
name: Sanchez-Guillen, J.
name: Wereszczynski, A.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We investigate the relation between the BPS baby Skyrme model and its vector meson formulation, where the baby Skyrme term is replaced by a coupling between the topological current $B_μ$ and the vector meson field $ω_μ$. The vector model still possesses infinitely many symmetries leading to infinitely many conserved currents which stand behind its solvability. It turns out that the similarities and differences of the two models depend strongly on the specific form of the potential. We find, for instance, that compactons (which exist in the BPS baby Skyrme model) disappear from the spectrum of solutions of the vector counterpart. Specifically, for the vector model with the old baby Skyrme potential we find that it has compacton solutions only provided that a delta function source term effectively screening the topological charge is inserted at the compacton boundary. For the old baby Skyrme potential squared we find that the vector model supports exponentially localized solitons, like the BPS baby Skyrme model. These solitons, however, saturate a BPS bound which is a nonlinear function of the topological charge and, as a consequence, higher solitons are unstable w.r.t. decay into smaller ones, which is at variance with the more conventional situation (a linear BPS bound and stable solitons) in the BPS baby Skyrme model.
description: 20 pages, 4 figures
Spectroscopy and excitation dynamicis of LiYF4:Pr3+ nanocrystals
Creators: name: Spelthann, Simon
Publisher: name: Hannover : Institutionelles Repositorium der Gottfried Wilhelm Leibniz Unviersität Hannover
Year: 2023
Subjects: subject: Lanthanides
subject: Nanocrystals
subject: Spectroscopy
subject: Monte Carlo Simulations
subject: Lanthanide
subject: Nanokristalle
subject: Spektroskopie
subject: Monte Carlo Simulationen
subject: Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik

description: Downsizing lanthanide-doped crystals to the nanoscale allows for new applications in a variety of forms as photonic composites. The dipole-forbidden 4f transitions in trivalent lanthanide ions promise high excited state lifetimes and quantum yields that are required for a plethora of applications, e.g., in lasers, phosphors, and quantum memories. However, nanocrystals undergo excitation quenching which takes mostly place at the nanocrystal surface and severely reduces the lifetime and quantum yield. So far, optimizing lanthanide nanocrystals required resource-consuming experimental procedures covering multiple syntheses, complex morphological characterization and extensive spectroscopy. In this thesis, LiYF4:Pr3+ was chosen as a model system because it is frequently used as bulk laser crystal whose spectroscopic properties are well investigated. A concentration series consisting of four samples (∼10nm, 0.7 − 1.47 at%) and a size series consisting of five samples (∼5 at%, 12−21nm) was spectroscopically characterized. As the main result of this investigation, an unexpected yet intense emission was observed that in bulk crystals is only exploitable through excitation of a different, subjacent energy level. Considering the spectroscopic results, a numerical model based on a Monte Carlo approach was implemented that takes the relevant energy exchange and quenching mechanisms into account. As main result of the present thesis, the numerical simulations were able to predict the excited state lifetimes and quantum yields of the nanocrystals with a maximum uncertainty of 12.6% for the lifetimes. To demonstrate the potential of this numerical approach, an undoped shell was added around the core particles in the model which extends the lifetime by up to 44%. Furthermore, spatiotemporal analysis of single nanocrystals points towards a new type of energy trapping in lanthanide nanocrystals. The numerical approach presented in this thesis constitutes an enormous potential for nanocrystal research, since it can be employed in any material system such as upconversion or avalanching nanocrystals. In the future, the considered approach allows for numerical optimization of the LiYF4:Pr3+ nanocrystals for application as quantum memories, lanthanide-based ratiometric nanothermometers, or efficient fused silica fiber lasers operating in the visible spectrum.
Toward a global and reproducible science for brain imaging in neurotrauma: the ENIGMA adult moderate/severe traumatic brain injury working group
Creators: name: Olsen, Alexander
name: Babikian, Talin
name: Bigler, Erin D.
name: Caeyenberghs, Karen
name: Conde, Virginia
name: Dams-O’Connor, Kristen
name: Dobryakova, Ekaterina
name: Genova, Helen
name: Grafman, Jordan
name: Håberg, Asta K.
name: Heggland, Ingrid
name: Hellstrøm, Torgeir
name: Hodges, Cooper B.
name: Irimia, Andrei
name: Jha, Ruchira M.
name: Johnson, Paula K.
name: Koliatsos, Vassilis E.
name: Levin, Harvey
name: Li, Lucia M.
name: Lindsey, Hannah M.
name: Livny, Abigail
name: Løvstad, Marianne
name: Medaglia, John
name: Menon, David K.
name: Mondello, Stefania
name: Monti, Martin M.
name: Newcombe, Virginia F.J.
name: Petroni, Agustin
name: Ponsford, Jennie
name: Sharp, David
name: Spitz, Gershon
name: Westlye, Lars T.
name: Thompson, Paul M.
name: Dennis, Emily L.
name: Tate, David F.
name: Wilde, Elisabeth A.
name: Hillary, Frank G.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Si: Enigma Tbi
Brain injury
Radiology
Open Science
Neurodegeneration
Rehabilitation
ENIGMA

description: Abstract: The global burden of mortality and morbidity caused by traumatic brain injury (TBI) is significant, and the heterogeneity of TBI patients and the relatively small sample sizes of most current neuroimaging studies is a major challenge for scientific advances and clinical translation. The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Adult moderate/severe TBI (AMS-TBI) working group aims to be a driving force for new discoveries in AMS-TBI by providing researchers world-wide with an effective framework and platform for large-scale cross-border collaboration and data sharing. Based on the principles of transparency, rigor, reproducibility and collaboration, we will facilitate the development and dissemination of multiscale and big data analysis pipelines for harmonized analyses in AMS-TBI using structural and functional neuroimaging in combination with non-imaging biomarkers, genetics, as well as clinical and behavioral measures. Ultimately, we will offer investigators an unprecedented opportunity to test important hypotheses about recovery and morbidity in AMS-TBI by taking advantage of our robust methods for large-scale neuroimaging data analysis. In this consensus statement we outline the working group’s short-term, intermediate, and long-term goals.
title: Adjustment to correctional confinement: Investigating the correlates of violence and disorder in a jail environment
Creators: name: Meyer III, Fred W.
Publisher: name: University of Nevada, Las Vegas
Year: 2010

description: This study examines the individual- and institutional-level variables that are correlated with violence and disorder within a jail facility. Previous research indicates that deviant behavior is one of the main challenges that negatively impacts the safe and effective management of correctional facilities. While many studies have been conducted on prison populations, few studies have focused upon jail populations. Using official institutional data, this study explores the factors associated with general infractions and violent misconduct among a stratified random sample of inmates (n=447) incarcerated during a one year period in a large county jail facility. The logistic regression and conjunctive analyses revealed that several variables were significantly correlated with institutional violence and disorder.  These variables had both individual and conjunctive or combined effects on the nature of institutional misconduct.  The results of this study are then discussed in terms of their implications for future research and practical policy for controlling disorder within correctional institutions.
Classical-Field Renormalization Flow of One-Dimensional Disordered Bosons
Creators: name: Pollet, L.
name: Prokof'ev, N. V.
name: Svistunov, B. V.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We show that in the regime when strong disorder is more relevant than field quantization the superfluid--to--Bose-glass criticality of one-dimensional bosons is preceded by the prolonged logarithmically slow classical-field renormalization flow of the superfluid stiffness at mesoscopic scales. With the system compressibility remaining constant, the quantum nature of the system manifests itself only in the renormalization of dilute weak links. On the insulating side, the flow ultimately reaches a value of the Luttinger parameter at which the instanton--anti-instanton pairs start to proliferate, in accordance with the universal quantum scenario. This happens first at astronomic system sizes because of the suppressed instanton fugacity. We illustrate our result by first-principles simulations.
description: 11 pages, 14 figures + references
Additional file 1 of The developing landscape of combinatorial therapies of immune checkpoint blockade with DNA damage repair inhibitors for the treatment of breast and ovarian cancers
Creators: name: Zhu, Lingling
name: Liu, Jiewei
name: Chen, Jiang
name: Zhou, Qinghua
Publisher: name: figshare
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Virology

description: Additional file 1. Table S1: Summary of Clinical Studies Combining Inhibitors Targeting DDR and ICB in Solid Cancer (ClinicalTrials.gov).
Additional file 1 of Lecanemab in patients with early Alzheimer’s disease: detailed results on biomarker, cognitive, and clinical effects from the randomized and open-label extension of the phase 2 proof-of-concept study
Creators: name: McDade, Eric
name: Cummings, Jeffrey L.
name: Dhadda, Shobha
name: Swanson, Chad J.
name: Reyderman, Larisa
name: Kanekiyo, Michio
name: Koyama, Akihiko
name: Irizarry, Michael
name: Kramer, Lynn D.
name: Bateman, Randall J.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Additional file 1.
Untersuchungen zur Chemie von [n.n]Ferrocenophanen
Creators: name: Tsang, Wing-Yin
Publisher: name: Hannover : Institutionelles Repositorium der Gottfried Wilhelm Leibniz Unviersität Hannover
Year: 2023
Subjects: subject: [1.1]ferrocenophane derivatives
subject: One-electron oxidation
subject: Lewis acid-induced Knoevenagel condensation
subject: McMurry coupling
subject: Bis[1.1]ferrocenophane
subject: [1.1]Ferrocenophan-Derivate
subject: Ein-Elektronen-Oxidation
subject: Lewis-Säuren induzierte Knoevenagel-Kondensation
subject: McMurry Kupplung
subject: Dewey Decimal Classification::500 | Naturwissenschaften::540 | Chemie

description: Im Rahmen dieses Forschungsprojektes wurden ausgehend von [1.1]Ferrocenophan-1,12-dion über eine Lewis-Säure induzierte Knoevenagel-Kondensation neue [1.1]Ferrocenophan-Derivate synthetisiert. Mit der Durchführung einer McMurry-Kupplung am [1.1]Ferrocenophan-1,12-dion konnte neben der Bildung des [1.1]Ferrocenophan-1-ons auch die Bildung eines Bis[1.1]ferrocenophans beobachtet werden, das an den verbrückenden Kohlenstoffatomen zwischen der jeweiligen [1.1]Ferrocenophan-Einheit eine gesättigte C–C-Bindung aufweist. Die Identität dieser Verbindung konnte durch Kristallstrukturanalyse bestätigt werden.
Das Purchstal
Creators: name: Grabherr, Norbert
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2017

description: -
description: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 1, Nr. 2 (1960): Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege