cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Calorie Restriction-induced SIRT6 Activation Delays Aging by Suppressing NF-κB Signaling
Creators: name: Zhang, Nannan
name: Li, Zhongchi
name: Mu, Wei
name: Li, Liyuan
name: Liang, Yaru
name: Lu, Maoyang
name: Wang, Zhuoran
name: Qiu, Ying
name: Wang, Zhao
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: Calorie restriction (CR) extends lifespan from yeast to mammals. SIRT6 is a member of the sirtuin family of NAD+-dependent histone deacetylases, which is responsible for mediating the effects of CR. The transcription factor NF-κB, which is involved in inflammation and aging, has been shown to be regulated by SIRT6. Here we describe the crucial role of SIRT6 in aging and inflammation. We show that CR had improved renal insufficiency and enhanced SIRT6 expression after 6-month treatment in aged mice. Culture cells in low glucose (LG) conditions also showed resistance to cell senescence and enhanced SIRT6 expression compared to normal glucose (NG) group, showing beneficial effects of the CR-mimic cultural conditions. Moreover, SIRT6 overexpression is sufficient to delay the replicative senescence of WI38 by attenuating NF-κB signaling, while SIRT6 knockdown results in accelerated cell senescence and overactive NF-κB signaling. These findings confirm the key status of CR and disclose the critical role of SIRT6 on aging and inflammation.
SmartAgroBiz: ML-Powered Farming and E-Commerce Solution
Creators: name: Subha S, Al Mohammad Khaleel-Ur-Rahmaan N, Arun Karthick N, Ashwin Suryaa G V, Giridhar Vignesh C
Publisher: name: Zenodo
Year: 2025

description: The farming industry encounters serious challenges that include market inefficiencies,volatility in prices, and climactic risks. SmartAgroBiz is a technology-driven mobile-enabledplatform that eliminates these problems through the filling of the gap that exists between farms andmarkets so that stable returns are realized at the same time as reducing wastage and eradication ofintermediaries. Advanced machine learning algorithms like Random Forest and ARIMA are utilizedthrough the platform for predictive analytics covering crop production, market dynamics, and climaticconditions. By incorporating real-time demand information and a safe digital payment platform,SmartAgroBiz increases transparency and efficiency in farm trade. Not only does the platformempower farmers with technology-enabled decision-making capabilities, but it also supports globalsustainability efforts like the United Nations Sustainable Development Goals (SDGs). This paperdiscusses the architecture of the system, machine learning integration, and its effects on sustainableagriculture, economic development, and food security. In addition, it addresses the difficulty ofapplying such a solution and provides future enhancements, such as AI-powered supply chainoptimization and blockchain traceability. SmartAgroBiz is a substantial advancement toward aneffective, profitable, and sustainable agricultural system.
РОЛЬ СЕМЬИ В КОРРЕКЦИОННОЙ РАБОТЕ С ДЕТЬМИ, ИМЕЮЩИМИ НАРУШЕНИЯ В РЕЧИ
Creators: name: Шорахимова, Лайло
Publisher: name: Zenodo
Year: 2025

description: Проблема речевых нарушений у детей представляет собой значимый вызов для современного общества, поскольку полноценное развитие речи является основой для успешной социализации, обучения и личностного становления. Речь, будучи сложной психической функцией, отражает уровень когнитивного развития, способности к коммуникации и адаптации в окружающем мире. Нарушения в речевом развитии могут проявляться в различных формах, от незначительных дефектов произношения до комплексных расстройств, затрагивающих все аспекты речи – фонетику, лексику, грамматику и связность. В этой связи, коррекционная работа с детьми, имеющими нарушения в речи, приобретает особую актуальность и требует комплексного подхода, в котором центральную роль играет семья.
T cell proliferation and adaptive immune responses are critically regulated by protein phosphatase 4
Creators: name: Liao, Fang-Hsuean
name: Hsiao, Wan-Yi
name: Lin, Yu-Chun
name: Chan, Yi-Chiao
name: Huang, Ching-Yu
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: The clonal expansion of activated T cells is pivotal for the induction of protective immunity. Protein phosphatase 4 (PP4) is a ubiquitously expressed serine/threonine phosphatase with reported functions in thymocyte development and DNA damage responses. However, the role of PP4 in T cell immunity has not been thoroughly investigated. In this report, our data showed that T cell-specific ablation of PP4 resulted in defective adaptive immunity, impaired T cell homeostatic expansion, and inefficient T cell proliferation. This hypo-proliferation was associated with a partial G1-S cell cycle arrest, enhanced transcriptions of CDK inhibitors and elevated activation of AMPK. In addition, resveratrol, a known AMPK activator, induced similar G1-S arrests, while lentivirally-transduced WT or constitutively-active AMPKα1 retarded the proliferation of WT T cells. Further investigations showed that PP4 co-immunoprecipitated with AMPKα1, and the over-expression of PP4 inhibited AMPK phosphorylation, thereby implicating PP4 for the negative regulation of AMPK. In summary, our results indicate that PP4 is an essential modulator for T cell proliferation and immune responses; they further suggest a potential link between PP4 functions, AMPK activation and G1-S arrest in activated T cells.
Comportement sismique des maçonneries non armées : de la campagne expérimentale à la modélisation numérique
Creators: name: Mordant, Christophe
name: Denoël, Vincent
name: Degée, Hervé
Publisher: name: Academic Journal of Civil Engineering
Year: 2020

description: La présente contribution décrit trois campagnes expérimentales visant à améliorer la compréhension du comportement des maçonneries portantes non armées sous action sismique. Au cours de ces campagnes, des essais cycliques et sur table à secousses ont été réalisés sur des murs simples ou présentant un détail constructif particulier (ouverture, mur perpendiculaire ou présence de joints en caoutchouc en pied et tête de mur pour des raisons acoustiques). Les murs testés, leur instrumentation et le déroulement des essais sont tout d’abord décrits. Ensuite, les principaux résultats expérimentaux sont fournis. Seuls les résultats utiles pour la modélisation numérique des murs étudiés sont repris ici. Parmi ces derniers, les propriétés mécaniques (modules d’élasticité et de cisaillement) et les courbes « force-déplacement » sont de première importance. Enfin, les murs sont modélisés à l’aide du logiciel TREMURI et les prédictions numériques obtenues sont comparées aux résultats expérimentaux. Cette comparaison montre qu’une modélisation de la maçonnerie à l’échelle « macro » prédit correctement le mode de ruine permet de reproduire le comportement global des murs de manière satisfaisante.
description: Academic Journal of Civil Engineering, Vol 34 No 1 (2016): Special Issue - RUGC 2016 Liège
Die Wahrnehmung von Anforderungen zur Planung von Unterricht und ihre Bezüge zu den beruflichen Entwicklungsaufgaben: Ein Vergleich deutscher und schweizerischer Lehrpersonen am Ende ihrer Ausbildung und in der Berufseinstiegsphase
Creators: name: Keller-Schneider, Manuela
name: Arslan, Elif
name: Maas, Jasper
name: Hericks, Uwe
Publisher: name: Zenodo
Year: 2017
Subjects: Ein- und zweiphasige Lehrerbildung
Ausbildung
Berufseinstieg
Planung von Unterricht
berufliche Entwicklungsaufgaben
subjektive Wahrnehmung

description: Eine Ausbildung legt Grundlagen, um auf den Einstieg in die eigenverantwortliche Berufsarbeit vorzubereiten. Dabei kann konzeptionell verschieden vorgegangen werden, wie Lehrer/innenbildungsmodelle in der Schweiz und in Deutschland zeigen. Im folgenden Beitrag wird untersucht, ob und inwiefern schweizerische und deutsche Lehrpersonen nach Abschluss ihrer ein- oder zweiphasigen Ausbildung berufliche Anforderungen different wahrnehmen. Mittels Fragebogen wurden schweizerische und deutsche Primarlehrpersonen am Ende ihrer Ausbildung und nach zwei Jahren eigenverantwortlicher Berufstätigkeit zu ihren Wahrnehmungen von umfassenden Berufsanforderungen (Entwicklungsaufgaben) und von Planungsanforderungen befragt. Ergebnisse zeigen, dass sich deutsche und schweizerische Ausbildungsabgänger/innen sowohl in der Wahrnehmung von Planungsanforderungen, als auch in der Positionierung dieser Anforderungen im Feld der beruflichen Entwicklungsaufgaben unterscheiden, Berufseinsteigende nach zwei Jahren eigenverantwortlicher Berufstätigkeit jedoch nicht. Die Auseinandersetzung mit den situierten Herausforderungen der eigenverantwortlichen Berufsarbeit und die damit einhergehende Professionalisierung scheinen ausbildungsmodellspezifische Schwerpunktsetzungen auszugleichen.
description: +repphzhbib2017A
Sample size determination for fold-increase endpoints defined by paired interval-censored data
Creators: name: Xu, Ying
name: F. Lam, K.
name: Bun Cheung, Yin
Publisher: name: Taylor & Francis
Year: 2016
Subjects: Medicine
Biotechnology
Mathematical Sciences not elsewhere classified
Cancer
Computational Biology

description: Medical studies often define binary end-points by comparing the ratio of a pair of measurements at baseline and end-of-study to a clinically meaningful cut-off. For example, vaccine trials may define a response as at least a four-fold increase in antibody titers from baseline to end-of-study. Accordingly, sample size is determined based on comparisons of proportions. Since the pair of measurements is quantitative, modeling the bivariate cumulative distribution function to estimate the proportion gives more precise results than using dichotomization of data. This is known as the distributional approach to the analysis of proportions. However, this can be complicated by interval-censoring. For example, due to the nature of some laboratory measurement methods, antibody titers are interval-censored. We derive a sample size formula based on the distributional approach for paired interval-censored data. We compare the sample size requirement in detecting an intervention effect using the distributional approach to a conventional approach of dichotomization. Some practical guidance on applying the sample size formula is given.
Screening of some vegetables for the biotransformation of bicyclo[3.3.1]nonane-2,6-diol diacetate
Creators: name: Celitan, Enrika
name: Zilinskas, Albinas
name: Sereikaite, Jolanta
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: Plant Biology

description: Vegetables as biocatalysts were screened for the stereoselective biotransformation of racemic bicyclo[3.3.1]nonane-2,6-diol diacetate. The best results were obtained using the roots of carrot (Daucus carota) and parsnip (Pastinaca sativa) and the rootstocks of ginger (Zingiber officinale). During the biotransformation of racemic bicyclo[3.3.1]nonane-2,6-diol diacetate the enzymatic hydrolysis took place. Under different reaction conditions, i.e. the reaction temperature and time, and using different plant material as biocatalyst, (1R,2R,5R,6R)-(+)-bicyclo[3.3.1]nonane-2,6-diol monoacetate or (1S,2S,5S,6S)-(-)-bicyclo[3.3.1]nonane-2,6-diol monoacetate were obtained as reaction products. (–)- Enantiomer with the optical purity of 29.3% was obtained at 25°C using parsnip as biocatalyst for 2 days and (+)- enantiomer with the optical purity of 44.1% was obtained at 30°C using carrot for 3 days.
Exploring effects of remote ischemic preconditioning in a pig model of hypothermic circulatory arrest
Creators: name: Herajärvi, Johanna
name: Anttila, Tuomas
name: Elitsa Y. Dimova
name: Laukka, Tuomas
name: Myllymäki, Mikko
name: Haapanen, Henri
name: Olenchock, Benjamin A.
name: Tuominen, Hannu
name: Puistola, Ulla
name: Karihtala, Peeter
name: Kiviluoma, Kai
name: Koivunen, Peppi
name: Anttila, Vesa
name: Juvonen, Tatu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy

description: Objectives. During aortic and cardiac surgery, risks for mortality and morbidity are inevitable. Surgical setups involving deep hypothermic circulatory arrest (DHCA) are effective to achieve organ protection against ischemic injury. The aim of this study was to identify humoural factors mediating additive protective effects of remote ischemic preconditioning (RIPC) in a porcine model of DHCA. Design. Twenty-two pigs were randomized into the RIPC group (n = 11) and the control group (n = 11). The RIPC group underwent four 5-minute hind limb ischemia-reperfusion cycles prior to cardiopulmonary bypass and DHCA. All animals underwent identical surgical procedures including 60 min DHCA at 18 °C. Blood samples were collected from vena cava and sagittal sinus at several time points. After the 8-hour follow-up period, the brain, heart, and kidney tissue samples were collected for tissue analyses. Results. Serum levels of brain damage marker S100B recovered faster in the RIPC group, after 4 hours of the arrest, (p Conclusions. The faster recovery of S100B, lower systemic lactate levels and favourable regional antioxidant response suggest possible neuronal cellular and mitochondrial protection by RIPC, whereas better cardiac index underlines functional effects of RIPC. The exact humoural factor remains unclear.
Continuous production of aqueous suspensions of ultra-fine particles of curcumin using ultrasonically driven mixing device
Creators: name: Komal Pandey
name: Amruta Chatte
name: Dalvi, Sameer
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Developing drug formulations for poorly water-soluble drugs is a major challenge for pharmaceutical industries as the poor water solubility limits bioavailability of these drugs. Production of nanoparticles/microparticles of these drugs is one of the ways to improve dissolution rates by increasing interfacial area for dissolution. Curcumin, a compound obtained from the rhizome of curcuma longa (turmeric roots), is a pharmaceutically viable molecule. However, poor aqueous solubility limits its therapeutic use. In this work, we report studies conducted to continuously produce aqueous suspensions of curcumin nano/micro particles. Influence of process parameters such as ultrasound, additives, and solvent to antisolvent ratio on polymorphic outcome and morphology of precipitated particles has been investigated. Ultrasound was found to greatly influence the polymorphic form and the morphology of precipitated particles. Nucleation rates, mixing time, and solid–liquid interfacial energies were also estimated to understand the effect of various processing parameters on the precipitation process.
Ultrafast removal of methylene blue from water by Fenton-like pretreated peanut hull as biosorbent
Creators: name: Lv, Dongcan
name: Jiang, Guangce
name: Li, Chengpeng
name: Zhu, Qianchen
name: Wang, Zhimin
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology
subject: Inorganic Chemistry

description: Modified biomass is a green and renewable sorbent to remove organic pollutants in water. In this study, an efficient bio-based adsorbent was obtained by Fenton-like pretreatment of peanut hull with FeOCl, which can be used to efficiently remove methylene blue from water. The adsorption experiment showed that under the conditions of 25°C, pH 6.0, MB concentration of 100 mg·L−1 and adsorbent dosage of 1.0 g·L−1, the adsorption equilibrium could be achieved within 6 min, with MB removal rate of 85.1% and maximum adsorption capacity of 132 mg·g−1, which was much higher than that of untreated peanut hull (64 mg·g−1). Material characterization showed that Fenton-like pretreatment resulted in the surface morphology change and pore structure formation of peanut hull, and the specific surface area increased significantly, which was an important reason for rapid adsorption. The adsorption mechanism showed that the adsorption of methylene blue followed pseudo second-order models, and conformed to Redlich-Peterson and Langmuir models. According to the thermodynamic analysis results, it is concluded that the adsorption process is endothermic and spontaneous. Adsorption mechanism includes hydrogen bonding, static electricity and van der Waals force.
Evaluation of in vitro cytotoxicity, biocompatibility, and changes in the expression of apoptosis regulatory proteins induced by cerium oxide nanocrystals
Creators: name: Shahanavaj Khan
name: Anees A. Ansari
name: Rolfo, Christian
name: Coelho, Andreia
name: Abdulla, Maha
name: Al-Khayal, Khayal
name: Ahmad, Rehan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Hematology

description: Cerium oxide nanocrystals (CeO2-NCs) exhibit superoxide dismutase and catalase mimetic activities. Based on these catalytic activities, CeO2-NCs have been suggested to have the potential to treat various diseases. The crystalline size of these materials is an important factor that influences the performance of CeO2-NCs. Previous reports have shown that several metal-based nanocrystals, including CeO2-NCs, can induce cytotoxicity in cancer cells. However, the underlying mechanisms have remained unclear. To characterize the anticancer activities of CeO2-NCs, several assays related to the mechanism of cytotoxicity and induction of apoptosis has been performed. Here, we have carried out a systematic study to characterize CeO2-NCs phase purity (X-ray diffraction), morphology (electron microscopy), and optical features (optical absorption, Raman scattering, and photoluminescence) to better establish their potential as anticancer drugs. Our study revealed anticancer effects of CeO2-NCs in HT29 and SW620 colorectal cancer cell lines with half-maximal inhibitory concentration (IC50) values of 2.26 and 121.18 μg ml–1, respectively. Reductions in cell viability indicated the cytotoxic potential of CeO2-NCs in HT29 cells based on inverted and florescence microscopy assessments. The mechanism of cytotoxicity confirmed by estimating possible changes in the expression levels of Bcl2, BclxL, Bax, PARP, cytochrome c, and β-actin (control) proteins in HT29 cells. Down-regulation of Bcl2 and BclxL and up-regulation of Bax, PARP, and cytochrome c proteins suggested the significant involvement of CeO2-NCs exposure in the induction of apoptosis. Furthermore, biocompatibility assay showed minimum effect of CeO2-NCs on human red blood cells.
Prediction of successful dose reduction or discontinuation of adalimumab, etanercept, or infliximab in rheumatoid arthritis patients using serum drug levels and antidrug antibody measurement
Creators: name: CAM Bouman
name: N Van Herwaarden
name: FHJ Van Den Hoogen
name: A Van Der Maas
name: BJF Van Den Bemt
name: AA Den Broeder
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Background: To evaluate if TNF inhibitor serum drug levels (DL) or anti-drug antibodies (ADAb) can predict successful dose reduction (in patients with high DL) or discontinuation (in patients with no/low DL or ADAb) in rheumatoid arthritis (RA) patients. Research design and methods: RA patients that were using adalimumab (n = 42), etanercept (n = 76) or infliximab (n = 51) and were doing well, were tapered until discontinuation or flare (1–1.5 year follow up). Random timed DL for adalimumab and etanercept and trough DL for infliximab were measured before dose reduction: Receiver-Operator-Curves (ROC) analyses with optimal cut-off DL were determined. Results: No predictive value of adalimumab and infliximab DL for all outcomes were found, except for an inverse association of lower etanercept DL and higher chance for successful dose reduction (Area Under the Curve (AUC) 0.36, 95% CI 0.23–0.49; cut-off <2.6 mg/l). In sub analyses, higher adalimumab trough DL predicted successful dose reduction (AUC 0.86, 0.58–1.00; cut-off >7.8). ADAb were infrequent and not predictive of successful discontinuation. Conclusions: No predictive value of baseline adalimumab, etanercept and infliximab DL or ADAb for successful dose reduction or discontinuation in RA was found in this context, with the possible exception of high adalimumab trough levels for successful dose reduction.
A commentary and correction on the article “Pansharpening by exploiting sharpness of the spatial structure”
Creators: name: Rong, Kaixuan
name: Wang, Shuang
name: Yang, Shuyuan
name: Jiao, Licheng
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Ecology
subject: FOS: Biological sciences

description: This study clarifies the implicit potential deficiency caused by the sparse cardinality parameter k in Rong et al. (2014). In addition, k = β × W × M × N (0.9 ≤ β < 1) is suggested to avert this potential deficiency, where β is a ratio controlling the amount of sparse cardinality, W is the number of multispectral bands and M × N is the size of panchromatic image. With the choice of k suggested in this study, the low rank matrix L and sparse matrix S obtained by Go Decomposition (Zhou and Tao 2011) can be iteratively optimized and solved. Thus, instead of choosing k as W × M × N in Rong et al. (2014), the potential deficiency that L is directly obtained as an analytic solution can be averted.
Binding modes of phosphotriesterase-like lactonase complexed with δ-nonanoic lactone and paraoxon using molecular dynamics simulations
Creators: name: Guan, Shanshan
name: Zhao, Li
name: Jin, Hanyong
name: Shan, Ning
name: Han, Weiwei
name: Wang, Song
name: Shan, Yaming
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: Phosphotriesterase-like lactonases (PLLs) have received much attention because of their physical and chemical properties. They may have widespread applications in various fields. For example, they show potential for quorum-sensing signaling pathways and organophosphorus (OP) detoxification in agricultural science. However, the mechanism by which PLLs hydrolyze, which involves OP compounds and lactones and a variety of distinct catalytic efficiencies, has only rarely been explored. In the present study, molecular dynamics (MD) simulations were performed to characterize and contrast the structural dynamics of DrPLL, a member of the PLL superfamily in Deinococcus radiodurans, bound to two substrates, δ-nonanoic lactone and paraoxon. It has been observed that there is a 16-fold increase in the catalytic efficiency of the two mutant strains of DrPLL (F26G/C72I) vs. the wild-type enzyme toward the hydrolysis of paraoxon, but an explanation for this behavior is currently lacking. The analysis of the molecular trajectories of DrPLL bound to δ-nonanoic lactone indicated that lactone-induced conformational changes take place in loop 8, which is near the active site. Binding to paraoxon may lead to conformational displacement of loop 1 residues, which could lead to the deformation of the active site and so trigger the entry of the paraoxon into the active site. The efficiency of the F26G/C72I mutant was increased by decreasing the displacement of loop 1 residues and increasing the flexibility of loop 8 residues. These results provide a molecular-level explanation for the experimental behavior.
Effect of physicochemical factors on extracellular fungal pigment-mediated biofabrication of silver nanoparticles
Creators: name: Bhatnagar, Sharad
name: Ogbonna, Christiana N.
name: Ogbonna, James C.
name: Aoyagi, Hideki
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: The extracellular pigment produced by Talaromyces purpurogenus was used as a reducing agent in the production of silver nanoparticles (AgNPs), and the effect of physicochemical parameters (pH and light) on the synthesis were examined. To evaluate the effect of pigment constituents on AgNP synthesis, fractions were obtained by thin layer chromatography. Ultraviolet–visible spectroscopy, transmission electron microscopy, dynamic light scattering (DLS), and Fourier transform infrared spectroscopy were used to characterize the biofabricated AgNPs. The synthesis of AgNPs was enhanced under alkaline conditions, emphasizing the role of sodium hydroxide (NaOH) as an accelerator, and the effect of light on yield could be clearly perceived up to pH 10. As the pH value was increased further, the light dependency of the reaction decreased, although the DLS data suggested variation in the size of AgNPs obtained in the presence and absence of light. The AgNPs produced at optimum pH in the presence of light were nearly spherical with a size distribution of 5–40 nm. The AgNP production process was pH-dependent and light-mediated, indicating that AgNPs with different properties could be generated by controlling these physicochemical factors.
Sustainable synthesis, in silico evaluation of potential toxicity and environmental fate, antioxidant and UV-filtering/photostability activity of phenolic-based thiobarbituric derivatives
Creators: name: Rioux, Benjamin
name: Mention, Matthieu M.
name: Alarcan, Jimmy
name: Abiola, Temitope T.
name: Peyrot, Cédric
name: Brunissen, Fanny
name: Braeuning, Albert
name: Stavros, Vasilios G.
name: Allais, Florent
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: The recent ban of some organic UV-filters – such as oxybenzone or octinoxate – considered toxic for coral reef, has heightened the need for eco-friendly alternatives, especially those synthesized using green approaches that reduce the carbon footprint. In this context, several thiobarbituric acid derivatives were synthetized from bio-based p-hydroxybenzaldehydes (e.g. vanillin, syringaldehyde) through a high-yielding sustainable Knoevenagel condensation, and their UV-filtering activity, stability and antiradical properties were investigated. The results showed promising UVA and blue light coverage over time, as well as competitive EC50 values in comparison to commercial antioxidants (i.e. BHA and BHT). In order to evaluate the potential of these molecules as substitutes to current petroleum-based UV-filters, the potential toxicity and fate in environment of these new compounds were evaluated in silico. This screening did not show a critical potential for toxicity, making them promising candidates for further in vitro and in vivo assessment.
Duvelisib: a phosphoinositide-3 kinase δ/γ inhibitor for chronic lymphocytic leukemia
Creators: name: Hima V. Vangapandu
name: Nitin Jain
name: Gandhi, Varsha
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: 110309 Infectious Diseases

description: Introduction: Frontline chemotherapy is successful against chronic lymphocytic leukemia (CLL), but results in untoward toxicity. Further, prognostic factors, cytogenetic anomalies, and compensatory cellular signaling lead to therapy resistance or disease relapse. Therefore, for the past few years, development of targeted therapies is on the rise. PI3K is a major player in the B-cell receptor (BCR) signaling axis, which is critical for the survival and maintenance of B cells. Duvelisib, a PI3K δ/γ dual isoform specific inhibitor that induces apoptosis and reduces cytokine and chemokine levels in vitro, holds promise for CLL. Areas covered: Herein, we review PI3K isoforms and their inhibitors in general, and duvelisib in particular; examine literature on preclinical investigations, pharmacokinetics and clinical studies of duvelisib either as single agent or in combination, for patients with CLL and other lymphoid malignancies. Expert opinion: Duvelisib targets the PI3K δ isoform, which is necessary for cell proliferation and survival, and γ isoform, which is critical for cytokine signaling and pro-inflammatory responses from the microenvironment. In phase I clinical trials, duvelisib as a single agent showed promise for CLL and other lymphoid malignancies. Phase II and III trials of duvelisib alone or in combination with other agents are ongoing.
Three new triterpenoid saponins from the roots of Ardisia crenata and their cytotoxic activities
Creators: name: Liu, Dai-Lin
name: Zhang, Xue
name: Zhao, Yanmin
name: Wang, Nai-Li
name: Yao, Xin-Sheng
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Three new triterpenoid saponins, ardisicrenoside O (1), ardisicrenoside P (2) and ardisicrenoside Q (3) together with three known compounds, 3β,16α-dihydroxy-30-methoxy-28, 30-epoxy-olean-12-en, cyclamiretin A 3-O-β-d-glucopyranosyl-(1→2) -α-l-arabinopyranoside and cyclamiretin A 3-O-β-d-glucopyranosyl-(1→4) -α-l-arabinopyranoside were isolated from the roots of Ardisia crenata Sims. Their structures were determined by one- and two-dimensional NMR techniques, including HSQC, HMBC and TOCSY experiments, as well as acid hydrolysis and GC analysis. All isolates were evaluated for the cytotoxic activities on two human cancer cell lines and compounds 3, 5 and 6 showed significant cytotoxicity.
Flexible Tweedie regression models for continuous data
Creators: name: Bonat, Wagner Hugo
name: Kokonendji, Célestin C.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Tweedie regression models (TRMs) provide a flexible family of distributions to deal with non-negative right-skewed data and can handle continuous data with probability mass at zero. Estimation and inference of TRMs based on the maximum likelihood (ML) method are challenged by the presence of an infinity sum in the probability function and non-trivial restrictions on the power parameter space. In this paper, we propose two approaches for fitting TRMs, namely quasi-likelihood (QML) and pseudo-likelihood (PML). We discuss their asymptotic properties and perform simulation studies to compare our methods with the ML method. We show that the QML method provides asymptotically efficient estimation for regression parameters. Simulation studies showed that the QML and PML approaches present estimates, standard errors and coverage rates similar to the ML method. Furthermore, the second-moment assumptions required by the QML and PML methods enable us to extend the TRMs to the class of quasi-TRMs in Wedderburn's style. It allows to eliminate the non-trivial restriction on the power parameter space, and thus provides a flexible regression model to deal with continuous data. We provide an R implementation and illustrate the application of TRMs using three data sets.
Clubiona norvegica Strand 1900
Creators: name: Esyunin, S. L.
name: Kazantsev, D. K
Publisher: name: Zenodo
Year: 2007
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Clubionidae
Clubiona
Clubiona norvegica

description: Clubiona norvegica Strand, 1900 MATERIAL. 1 ♀ (PSU- 4377), 4, multiherbaceous Betula forest, 19.VII.2007, Kolesnikova À.À. REMARKS. The record of C. norvegica from the vicinity of Perm by Esyunin & Efimik [1995] is actually referred to C. stagnatilis Kulczynski, 1897. Thus, the known southern border of the C. norvegica range in the Urals passes across the North Urals [Pakhorukov, 1977; present data].
description: Published as part of Esyunin, S. L. & Kazantsev, D. K, 2007, On the spider (Aranei) fauna of the Pechoro - Ilychskiy Reserve (North Urals), with the description of a new Agroeca species (Liocranidae), pp. 245-250 in Arthropoda Selecta 16 (4) on page 246, DOI: 10.5281/zenodo.584085
description: {"references": ["Pakhorukov N. M. 1977. [Materials on the spider fauna of the eastern slope of the North Urals]. Perm. 26 p. (Deposited in VINITI, No 4208 - 77) [in Russian]."]}
Bathyphantes eumenis L. Koch 1879
Creators: name: Esyunin, S. L.
name: Kazantsev, D. K
Publisher: name: Zenodo
Year: 2007
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Linyphiidae
Bathyphantes
Bathyphantes eumenis

description: Bathyphantes eumenis (L. Koch, 1879) B. eumenis: Pakhorukov & Utochkin, 1977b, p. 907, fig. 1 (♀). Bathyphantes eumenis: Wozny & Szajka, 1985, p. 575, figs 1— 5 (♂ ♀) MATERIAL. 5 ♀♀ (PSU- 4639), I, creek of Malaya Garevka River, bottomland Picea forest with high-herbage, 30.VI— 02.VII.2007, DK. REMARKS. This species has been recorded from the Pechoro-Ilychskiy Reserve and also figured by Pakhorukov [Pakhorukov & Utochkin, 1977b; Pakhorukov, 1980]. In 1985, Wożny & Czajka [1985] showed that Bathyphantes simillimus (L. Koch, 1879) should be a synonym of B. eumenis. Contrary, Eskov [1994] did not support the opinion on the identity of these species and considered Pakhorukov̕s records as B. simillimus. We and our colleagues [Tanasevitch and Marusik, personal comm.] are in favour of Wozny & Szajka̕s viewpoint, and have therefore identified our specimens as the Holarctic boreal species, B. eumenis.
description: Published as part of Esyunin, S. L. & Kazantsev, D. K, 2007, On the spider (Aranei) fauna of the Pechoro - Ilychskiy Reserve (North Urals), with the description of a new Agroeca species (Liocranidae), pp. 245-250 in Arthropoda Selecta 16 (4) on page 246, DOI: 10.5281/zenodo.584085
description: {"references": ["Pakhorukov N. M., Utochkin A. S. 1977 b. [Spider species of the family Linyphiidae (Aranei) from the northern Urals, littleknown and new to the fauna of the USSR] // Entomol. obozr. Vol. 56. No. 4. P. 907 - 911 [in Russian].", "Wozny M., Czajka M. 1985. Bathyphantes eumenis (L. Koch, 1879) (Aranei, Linyphiidae) in Poland, and its synonyms // Polskie Pismo Ent. Vol. 55. P. 575 - 582.", "Pakhorukov N. M. 1980 a. [Spiders of the Yaksha profile] // Vzaimosvyazi komponentov lesnykh i bolotnykh ekosystem sredney taigi Priuraliya. Leningrad: Nauka. P. 160 - 171 [in Russian]."]}
Embolisation of pulmonary radio frequency pathway – a randomised trial
Creators: name: Izaaryene, Jean
name: Mancini, Julien
name: Louis, Guillaume
name: Chaumoitre, Kathia
name: Jean-Michel Bartoli
name: Vidal, Vincent
name: Jean-Yves Gaubert
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Purpose: Pneumothorax is the most common complication following a pulmonary percutaneous radiofrequency ablation (RFA), and thoracic drainages are the most frequent causes of an extended hospital stay. Our main objective was to show that the use of gelatin torpedoes may significantly decrease the number of chest tube placement. Materials and methods: Seventy-three patients were prospectively included in this study and then randomised into two groups: 34 with embolisation and without 39 without embolisation. Each group was comparable for different pneumothorax risk factors. Results: There were 16 (47%) pneumothorax in Group A (“with embolisation”), which was significantly lower (p p = .02) was significantly lower in Group A (22.7% average, standard deviation 15.6%) than in Group B (average 34.1%, standard deviation 17.1%). The number of drainages was significantly smaller in those with embolisation (3 drainages or 8%) than those without embolisation (25 drainages or 64%) (p Conclusion: When using absorbable gelatin torpedoes, pulmonary RFA pathways embolisation significantly decreased the number of pneumothorax and thoracic drainages to the advantage of therapeutic abstention and exsufflation, non-invasive and functional operational techniques.
A simple dual-channel sensor for detecting cyanide in water with high selectivity and sensitivity
Creators: name: Wei, Tai-Bao
name: Cheng, Xiao-Bin
name: Li, Hui
name: Lin, Qi
name: Yao, Hong
name: Zhang, You-Ming
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Plant Biology

description: Taking advantage of the special nucleophilicity of cyanide, a new simple colorimetric chemosensor has been synthesised. This allows a deprotonation reaction to monitoring the cyanide. With the addition of CN− to the chemosensor aqueous solution, which could induce a change in the solution colour from yellowish to deep yellow, while no colour change could be observed in the presence of other hackneyed anions, by which CN− can be distinguished from other anions immediate with the naked eye. At the same time, a fluorescence quenching was implemented upon adding cyanide into the chemosensor aqueous solution. The absorption spectra detection limits of the chemosensor for cyanide was 5.35 × 10−8 M and the fluorescence spectra detection limit was 2.63 × 10−8 M. The cyanide test strips based on the chemosensor could serve as a convenient cyanide test kits. Furthermore, the chemosensor was successfully applied to detect cyanide in sprouting potatoes. A novel chemosensor FC is demonstrated to sense CN− in aqueous media based on the mechanism of deprotonation reactions and electric charge transferring. This work provides a novel approach for the selective recognition of CN− anions.
Duvelisib: a phosphoinositide-3 kinase δ/γ inhibitor for chronic lymphocytic leukemia
Creators: name: Hima V. Vangapandu
name: Nitin Jain
name: Gandhi, Varsha
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: 110309 Infectious Diseases

description: Introduction: Frontline chemotherapy is successful against chronic lymphocytic leukemia (CLL), but results in untoward toxicity. Further, prognostic factors, cytogenetic anomalies, and compensatory cellular signaling lead to therapy resistance or disease relapse. Therefore, for the past few years, development of targeted therapies is on the rise. PI3K is a major player in the B-cell receptor (BCR) signaling axis, which is critical for the survival and maintenance of B cells. Duvelisib, a PI3K δ/γ dual isoform specific inhibitor that induces apoptosis and reduces cytokine and chemokine levels in vitro, holds promise for CLL. Areas covered: Herein, we review PI3K isoforms and their inhibitors in general, and duvelisib in particular; examine literature on preclinical investigations, pharmacokinetics and clinical studies of duvelisib either as single agent or in combination, for patients with CLL and other lymphoid malignancies. Expert opinion: Duvelisib targets the PI3K δ isoform, which is necessary for cell proliferation and survival, and γ isoform, which is critical for cytokine signaling and pro-inflammatory responses from the microenvironment. In phase I clinical trials, duvelisib as a single agent showed promise for CLL and other lymphoid malignancies. Phase II and III trials of duvelisib alone or in combination with other agents are ongoing.
A New Vision for University Governance, Pedagogies and Student Engagement
Creators: name: Popenici, Stefan
Publisher: name: figshare
Year: 2017
Subjects: subject: Education
subject: 130103 Higher Education
subject: FOS: Educational sciences

description: p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 10.0px Times} Drawing on recent empirical and theoretical studies, this chapter critically examines the role of social, culture and economic factors in shaping and opening possibilities for educational transformations of universities and student engagement. Considering the impact on higher education of rising inequality, unemployment, underemployment and youth marginalization, this study explores risks and opportunities for change of teaching, research and student participation in higher education. Underlining the need to explore alternative designs for a sustainable future, this paper investigates trends and challenges for policy makers and education providers alike. Exploring the vision about what an engaged student could be like in an alternative scenario for higher education this study suggests a common set of general policy goals and pedagogical directions for the future.
Oedothorax agrestis Blackwall 1853
Creators: name: Esyunin, S. L.
name: Kazantsev, D. K
Publisher: name: Zenodo
Year: 2007
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Linyphiidae
Oedothorax
Oedothorax agrestis

description: Oedothorax agrestis (Blackwall, 1853) MATERIAL. 6 ♂♂, 50 ♀♀ (PSU- 3264), I, beach bank of river, 23.IX.2003, O.L. Makarova.
description: Published as part of Esyunin, S. L. & Kazantsev, D. K, 2007, On the spider (Aranei) fauna of the Pechoro - Ilychskiy Reserve (North Urals), with the description of a new Agroeca species (Liocranidae), pp. 245-250 in Arthropoda Selecta 16 (4) on page 247, DOI: 10.5281/zenodo.584085
Proteomic insights into the functional basis for the response regulator DrRRA of Deinococcus radiodurans
Creators: name: Wang, Liangyan
name: Hu, Jing
name: Liu, Mengjia
name: Yang, Su
name: Zhao, Ye
name: Cheng, Kaiying
name: Xu, Guangzhi
name: Li, Mingfeng
name: Tian, Bing
name: Hua, Yuejin
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Mental Health

description: Purpose To investigate the function basis of the recently discovered response regulator, drRRA (DNA damage response regulator A) in Deinococcus radiodurans, we compared the proteomic profile of the radiation-sensitive drRRA mutant with that of wild-type strain under both non-stress and gamma radiation treatment. Materials and methods Total proteins of D. radiodurans cells were subjected to two-dimension electrophoresis. Protein spots in 2-Dimension gels were silver stained and scanned. Spots that changed significantly in expression levels were selected for mass spectrometry analysis. Seven genes encoding representative proteins were knocked out for stress resistance analysis. Results A total of 52 proteins displayed significant expression level changes at least 1.5-fold in the mutant relative to wild-type strain under non-stress conditions, with 31 repressed and 21 induced proteins, which might affect the cell response of D. radiodurans to gamma radiation. The proteins were distributed into functional groups including stress response, metabolism, and function unknown. Disruptions of several altered proteins including DRA0259 (Catalase E) and DR1538 (Osmotically inducible protein C), reduced the antioxidant activity of D. radiodurans. Conclusion Combined with our previous result of transcriptional profile, we further confirmed that inactivation of DrRRA affects the expression of various stress response systems.
Trichopterna thorelli Westring 1861
Creators: name: Esyunin, S. L.
name: Kazantsev, D. K
Publisher: name: Zenodo
Year: 2007
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Linyphiidae
Trichopterna
Trichopterna thorelli

description: Trichopterna thorelli (Westring, 1861) * MATERIAL. 2 ♂♂ (PSU- 4301), 2, grassy bog with dwarf Betula, VI.2007, DK.
description: Published as part of Esyunin, S. L. & Kazantsev, D. K, 2007, On the spider (Aranei) fauna of the Pechoro - Ilychskiy Reserve (North Urals), with the description of a new Agroeca species (Liocranidae), pp. 245-250 in Arthropoda Selecta 16 (4) on page 247, DOI: 10.5281/zenodo.584085