cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
An ultrafast optical parametric laser for driving high energy density science
Creators: name: Mecseki, Katalin
Publisher: name: Imperial College London
Year: 2013

description: This thesis describes the development of a multi-mJ, few-cycle, absolute-phase controlled laser system based on optical parametric chirped pulse amplification (OPCPA) operating at a kHz repetition rate. A laser system with these specifications will provide a table-top platform to enable a broad range of experiments in demanding research areas, including laser electron acceleration and the creation of exotic highenergy density plasmas from solid targets. The approach of the work is a combination of both experimental effort and numerical simulations used to guide and aid interpretation of laboratory studies. The non-collinear parametric gain stages of the laser have been optimised using detailed numerical simulations. A comparison is given on phase matching conditions in BBO and LBO crystals along with a novel nonlinear material BiBO. The production of 600 μJ pulses with a bandwidth that supports a transform limited temporal duration of 8.5 fs is presented in a three stage BBO based design. An all optical, low-jitter synchronisation scheme for the OPCPA pump and signal pulses has been designed and implemented by use of solitonic wavelength shifting in a photonic crystal fiber (PCF). Commercially available fibers with various core sizes have been assessed. The propagation of few-cycle pulses in the PCF has been studied by numerically solving the generalised Schr¨odinger equation with the splitstep Fourier method. An OPA pump laser with excellent spatial and temporal qualities has been developed. Amplification of the PCF output at 1053 nm is achieved in a regenerative diode pumped Nd:YLF amplifier and a multipass power amplifier. Self-phase modulation and gain narrowing is greatly reduced using a customised 500 μm low-finesse etalon in the regenerative amplifier cavity. Spectral modulation was found to increase both frequency doubling and parametric amplification efficiency and stability. The construction of an alternative 10 Hz, high-energy pump beam line is also presented.
Fermion-Fermion and Boson-Boson Amplitudes: Surprising Similarities
Creators: name: Dvoeglazov, Valeri V.
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Amplitudes for boson-boson and fermion-boson interactions are calculated in the second order of perturbation theory in the Lobachevsky space. An essential ingredient of the used model is the Weinberg's $2(2j+1)$ component formalism for describing a particle of spin $j$, recently developed substantially. The boson-boson amplitude is then compared with the two-fermion amplitude obtained by Skachkov long ago on the ground of the hamiltonian formulation of quantum field theory on the mass hyperboloid, $p_0^2 -{\vec p}^{2}=M^2$, proposed by Kadyshevsky. The parametrization of the amplitudes by means of the momentum transfer in the Lobachevsky space leads to same spin structures in the expressions of $T$ matrices for the fermion and the boson cases. However, certain differences are found. Possible physical applications are discussed.
description: LaTeX file (sprocl.sty), 4pp. Presented at the IV Wigner Symp
Assessing effects of behavioral intervention on treatment outcomes among patients initiating HIV care: Rationale and design of iENGAGE intervention trial
Creators: name: Westfall, A.O
name: Moore, R
name: Crane, H.M
name: Bryan, L
name: Knudson, A
name: Willig, J
name: Zinski, A
name: Napravnik, S
name: Amico, K.R
name: Modi, R
name: Quinlivan, E.B
name: Golin, C
name: Keruly, J
name: Mugavero, M.J
name: Saag, M.S
Publisher: name: Elsevier Inc.
Year: 2018

description: During the initial year of HIV diagnosis, while patients are often overwhelmed adjusting to this life changing diagnosis, they must develop self-care behaviors for attending regular medical care visits and antiretroviral therapy (ART) adherence to achieve and sustain viral suppression (VS). Maintaining “HIV adherence” and integrating it into one's daily life is required to sustain VS over time. The HIV care continuum or “treatment cascade,” an epidemiological snapshot of the national epidemic in the United States (US), indicates that a minority of persons living with HIV (PLWH) have achieved VS. Little evidence exists regarding the effects of interventions focusing on PLWH newly initiating outpatient HIV care. An intervention that focuses on both retention in care and ART adherence skills delivered during the pivotal first year of HIV care is lacking. To address this, we developed a theory-based intervention evaluated in the Integrating Engagement and Adherence Goals upon Entry (iENGAGE) study, a National Institute of Allergy and Infectious Diseases (NIAID) funded randomized behavioral intervention trial. Here we present the study objectives, design and rationale, as well as the intervention components, targeting rapid and sustained VS through retention in HIV care and ART adherence during participants' first year of HIV care. The primary outcome of the study is 48-week VS (<200 c/mL). The secondary outcomes are retention in care, including HIV visit adherence and visit constancy, as well as ART adherence.
Generalized pseudo-coefficients of discrete series of $p$-adic groups
Creators: name: Choiy, Kwangho
Publisher: name: arXiv
Year: 2018
Subjects: subject: Representation Theory (math.RT)
subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 22E50 (Primary), 22E35 (Secondary)

description: Let $G$ be a connected reductive group over a $p$-adic field $F$ of characteristic 0 and let $M$ be an $F$-Levi subgroup of $G.$ Given a discrete series representation $σ$ of $M(F),$ we prove that there exists a locally constant and compactly supported function on $M(F),$ which generalizes a pseudo-coefficient of $σ.$ This function satisfies similar properties to the pseudo-coefficient, and its lifting to $G(F)$ is applied to the Plancherel formula.
Resilience and HIV: a review of the definition and study of resilience
Creators: name: Fava, J.L
name: Howe, C.J
name: Earnshaw, V.A
name: Mugavero, M.J
name: Dulin, A.J
name: Napravnik, S
name: Carey, M.P
name: Hogan, J.W
name: Dale, S.K
Publisher: name: Routledge
Year: 2018

description: We use a socioecological model of health to define resilience, review the definition and study of resilience among persons living with human immunodeficiency virus (PLWH) in the existing peer-reviewed literature, and discuss the strengths and limitations of how resilience is defined and studied in HIV research. We conducted a review of resilience research for HIV-related behaviors/outcomes of antiretroviral therapy (ART) adherence, clinic attendance, CD4 cell count, viral load, viral suppression, and/or immune functioning among PLWH. We performed searches using PubMed, PsycINFO and Google Scholar databases. The initial search generated 14,296 articles across the three databases, but based on our screening of these articles and inclusion criteria, n = 54 articles were included for review. The majority of HIV resilience research defines resilience only at the individual (i.e., psychological) level or studies individual and limited interpersonal resilience (e.g., social support). Furthermore, the preponderance of HIV resilience research uses general measures of resilience; these measures have not been developed with or tailored to the needs of PLWH. Our review suggests that a socioecological model of health approach can more fully represent the construct of resilience. Furthermore, measures specific to PLWH that capture individual, interpersonal, and neighborhood resilience are needed.
title: ADCO, Cartulaire de Cîteaux pour la grange et seigneurie d'Ouges (XVe siècle), Cart. 173 (11 H 939), 226 folios, f. 0421
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2015
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire de Cîteaux pour la grange et seigneurie d'Ouges (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 173 (11 H 939), 226 folios, f. 0421, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour la grange et seigneurie d'Ouges (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 173 (11 H 939), 226 folios, f. 0421, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Oral history interview with Leo Castelli 1977
Publisher: name: Columbia University
Year: 2019
Subjects: Art dealers
Art, Modern--20th century
Art--Collectors and collecting
Art galleries, Commercial

description: Early life and family; career in insurance and banking; Galerie Drouin, Paris, 1939; escape from occupied France to United States, 1941; years in U.S. Army; first experiences with collecting; studies in economic history, Columbia University; origins of New York gallery.
Exact Wavefunctions in a Noncommutative Field Theory
Creators: name: Bak, Dongsu
name: Kim, Sung Ku
name: Soh, Kwang-Sup
name: Yee, Jae Hyung
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider the nonrelativistic field theory with a quartic interaction on a noncommutative plane. We compute the four point scattering amplitude within perturbative analysis to all orders and identify the beta function and the running of the coupling constant. Since the theory admits an equivalent description via the N particle Schrodinger equation, we regain the scattering amplitude by finding an exact scattering wavefunction of the two body equation. The wave function for the bound state is also identified. These wave functions unusually have two center positions in the relative coordinates. The separation of the centers is in the transverse direction of the total momentum and grows linearly with the noncommutativity scale and the total momentum, exhibiting the stringy nature of the noncommutative field theory.
description: Typos corrected. 7 pages
Predictors of Longitudinal Trajectories of Alcohol Consumption in People with HIV
Creators: name: Cropsey, K.L
name: Napravnik, S
name: Saag, M.S
name: Geng, E
name: Hutton, H
name: Chander, G
name: Crane, H.M
name: Mathews, W.C
name: McCaul, M.E
name: Mayer, K.H
name: Bilal, U
name: Lau, B
name: Mugavero, M.J
Publisher: name: Blackwell Publishing Ltd
Year: 2018

description: Background: Our aim was to describe alcohol consumption trajectories in a cohort of people living with HIV and determine clinical and sociodemographic predictors of each trajectory. Methods: This is a prospective cohort study of 7,906 patients in the 7 Centers for AIDS Research Network of Integrated Clinical Systems sites. Alcohol consumption was categorized as none, moderate, and alcohol misuse. Predictors included age, race/ethnicity, depressive or anxiety symptoms, illicit drug use (opioids, methamphetamines, cocaine/crack), marijuana use, hepatitis C virus (HCV) infection, HIV transmission risk factor, and HIV disease progression. We estimated sex-stratified alcohol consumption trajectories and their predictors. Results: We found 7 trajectories of alcohol consumption in men: stable nondrinking and increased drinking (71% and 29% of initial nondrinking); stable moderate, reduced drinking, and increased alcohol misuse (59%, 21%, and 21% of initial moderate alcohol use); and stable alcohol misuse and reduced alcohol misuse (75% and 25% of initial alcohol misuse). Categories were similar in women, except lack of an increase to alcohol misuse trajectory among women that begin with moderate use. Older men and women were more likely to have stable nondrinking, while younger men were more likely to increase to or remain in alcohol misuse. Minorities, people with depressive or anxiety symptoms, HCV-infected individuals, and people who injected drugs were more likely to reduce use. Illicit drug use was associated with a reduction in overall drinking, while marijuana use was associated with stable moderate drinking or misuse. Conclusions: Longitudinal trajectories of increasing alcohol use and stable misuse highlight the need to integrate routine screening and alcohol misuse interventions into HIV primary care.
The molecular basis of flowering time regulation
Creators: name: Charles, David
Publisher: name: Imperial College London
Year: 2013

description: Flowering is controlled by a series of signals integrated to regulate gene expression and coordinate development. The flowering hormone FLOWERING LOCUS T (FT) positively regulates flowering while the highly homologous TERMINAL FLOWERING 1 (TFL1) negatively regulates flowering. FT is recruited to the promoter in a complex with FD, a transcription factor belonging to the bZIP family, and 14-3-3. This complex is called flowering activating complex (FAC). Here TFL1 is shown to form a complex with 14-3-3 proteins and FD that has striking similarity to the FAC. By probing the extended loop of TFL1 a small region was identified towards the N-terminus of the loop that is involved in mediating the interaction with 14-3-3. This TFL1–14-3-3 platform can interact with the C-terminus of FD, and moreover this interaction occurs between FD and 14-3-3 rather than directly between FD and TFL1 as had been previously speculated. Results indicate that the TFL1–14-3-3 complex, but not FT–14-3-3, can interact with the AP1 promoter from Arabidopsis and that FD is not required for this interaction. In addition, we have located a region of three residues near the C-terminal portion of the loop that when mutated can convert FT from an activator of flowering into a strong repressor of flowering in vivo. Overall, the results suggest that TFL1 can associate with DNA and recruit FD to specific regulatory sites via 14-3-3 proteins, while FT is recruited via FD to a different region within the AP1 promoter region. The data thus provide the basis for a mechanistic model for the antagonistic functions of FT and TFL1 in regulating flowering.
Discovery processes & the organization of innovation
Creators: name: Kandasamy, Gajendran
Publisher: name: Imperial College London
Year: 2011

description: The thesis comprises four key papers, which provide fresh perspectives pertaining to the key factors in the management of innovation: new ideas, people, transactions and institutions. First, a model of discovery is proposed, highlighting the importance of problem reshaping and shifting in addition to usual problem solving approach. To illustrate how they can be incorporated within existing models, the conventional NK model is adapted in a novel way that not necessarily constrains agents to local optima nearby. The extended model is then used to study effects of curiosity and conditions under which analogy, recombination or local search would be effective. Building on this model, we show how satisficing behaviour of agents can be described by using cognitive constructs such as attention and stimulus, which moderate the gap between local (agent) and non-local (real-world) information. Second, Innovation entails the interfacing of communities with different traditions and aspirations, in particular, the science and business domains. Through a quasi-experimental design, we explore the micro-foundations of the contact and conflict which define the science-business divide, strategies for mitigating discordance and exploit synergies are discussed. Third, the attempt to understand innovation as intra-firm or inter-firm process from a consistent perspective within the existing theories of the firm has provoked a reconceptualization of the 'firm'. A reductionist approach at the level of actions and assets of the firm is found to achieve this reconciliation and also helps introduce the concepts of quasi-boundary to appreciate interaction of firms with the market and the institutions. Third, the innovation process occasionally faces institutional impediments. One of the preeminent changes has been the involvement of the universities in innovation system, where its full commercial potential was realized over a century. The historical observation of how multiple institutions were reformed provides new insights into the mechanism of institutional entrepreneurship. Finally, consolidation of each of the factors requires acknowledgment that the innovation process exists in the context of each other, and are subject to evolution and extraneous influences. The conclusion is an attempt at synthesizing the four factors towards understanding the overarching dynamics in the innovation ecosystem. To leverage on the independent developments at each level, a proposal to build a consistent multi-level coherent framework for innovation is suggested.
MCG+00-32-16: An Irregular Galaxy Close to the Lowest Redshift Absorber on the 3C 273 Line of Sight
Creators: name: Hoffman, G. L.
name: Lu, N. Y.
name: Salpeter, E. E.
name: Connell, B. M.
name: Fromhold-Treu, R.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: MCG+00-32-16 is the galaxy closest in position-velocity space to the lowest redshift Ly$α$ absorber along the line-of-sight to the quasar 3C 273. Its projected separation is 204 (d/19 Mpc) kpc, where d is the distance from the Milky Way to the galaxy, and the redshift difference is only 94 km/s; HI 1225+01 is slightly closer in projected separation to the absorber, but has a greater redshift difference. We present HI synthesis array mapping and CCD photometry in B and R for MCG+00-32-16. The HI disk is rotating in such a way that the side of the galaxy closer to the sight-line to the quasar has the larger velocity difference from the absorber. The absorber may be a ``failed dwarf'' member of a poor galaxy group of which MCG+00-32-16 and HI 1225+01 are the only members to have formed stars.
description: 14 pages, 9 figures, accepted by Astrophysical Journal
On the $W$-algebra in the Calegero-Sutherland model using the Exchange operators
Creators: name: Narayanan, V.
name: Sivakumar, M.
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the $W_\infty$ algebra in the Calegero-Sutherland model using the exchange operators. The presence of all the sub-algebras of $W_\infty$ is shown in this model. A simplified proof for this algebra, in the symmetric ordered basics, is given. It is pointed out that the algebra contains in general, nonlinear terms. Possible connection to the nonlinear $W_\infty$ is discussed.
description: Plain Tex, no figures, 13 pages
Evaluating the cost-effectiveness of secukinumab in moderate-to-severe psoriasis: a Japanese perspective
Creators: name: Atsuyuki Igarashi
name: Igarashi, Ataru
name: Graham, Christopher N.
name: Gilloteau, Isabelle
name: Tani, Yumiko
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Aim: To evaluate the cost-effectiveness of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, compared to other clinically used biologics (adalimumab, infliximab, and ustekinumab) in Japan for the treatment of moderate-to-severe psoriasis from the healthcare system (total costs) and patient co-payment (using different frequencies of drug purchase) perspectives. Methods: A decision-tree (first year)/Markov model (subsequent years), with an annual cycle, was developed. The model adopted a 5-year time horizon. Efficacy inputs were obtained from a mixed-treatment comparison analysis, and other model inputs were collected from published literature and local Japanese sources. Model outcomes included quality-adjusted life years (QALYs) and an incremental cost-effectiveness ratio (ICER) in terms of cost per QALY gained. The annual discounting rate of 2% was applied to both costs and outcomes. Results: Results for the healthcare system perspective showed that secukinumab had the highest number of quality-adjusted life years (QALYs) (4.07) vs other biologics, dominated ustekinumab and infliximab, and the ICER of secukinumab compared to adalimumab was ¥8,418,222/QALY gained. In the patient co-payment perspective with the monthly purchase of drugs, ustekinumab had the lowest co-payment cost, followed by infliximab, adalimumab, and secukinumab. In the patient co-payment perspective with a once every 3 months purchase of secukinumab and adalimumab, the co-payment costs of secukinumab, adalimumab, and ustekinumab became comparable, and infliximab had the highest co-payment cost. Limitations: Only short-term efficacy data was modeled, as there was a lack of data on long-term outcomes. Treatment sequencing was restricted to first-line biologic treatment. Drop-out rates for comparators were assumed to be equivalent to secukinumab in the absence of available data. Conclusions: Secukinumab is a cost-efficient treatment for moderate-to-severe psoriasis, providing greater health outcomes to patients at lower total costs compared to infliximab and ustekinumab, as well as comparable patient co-payment relative to other biologic treatments.
Histology of Sculpin spp. in East Greenland. II. Histopathology and trace element concentrations
Creators: name: Kaarsholm, Henrik M.
name: Verland, Ninna
name: Nørregaard, Rasmus D.
name: Bach, Lis
name: Søndergaard, Jens
name: Rigét, Frank F.
name: Dietz, Rune
name: Hansen, Martin
name: Eulaers, Igor
name: Desforges, Jean-Pierre
name: Leifsson, Pall S.
name: Dang, Mai
name: Nowak, Barbara
name: Sonne, Christian
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: For many years, the sculpin has been utilized as a sentinel monitoring species for anthropogenic impacts on the marine environment. To further develop its potential as a screening model body burdens of several trace elements, including cadmium (Cd), copper (Cu), mercury (Hg), lead (Pb) and selenium (Se), were investigated. In addition, histopathology in shorthorn sculpins (Myoxocephalus scorpius; n = 20) and fourhorn sculpins (Myoxocephalus quadricornis; n = 10) were examined at three sites around the Scoresby Sound settlement in Central East Greenland. Fourhorn sculpins caught at the most distant site from the settlement, contained significantly higher hepatic Cu and Cd concentrations as well as significantly elevated gill Pb levels compared to the shorthorn sculpins collected at two other sites closer to the settlement. Histological examinations showed that fish with significantly higher concentrations of hepatic Cd and Se exhibited greater nuclear alterations, interstitial hyperplasia/hypertrophy, interstitial mononuclear infiltrations and granulomas. Further, fish with higher Cd and Cu gill tissue levels displayed a significantly higher number of cytoplasmic alterations and lamellar epithelium lifting, hypertrophic and hyperplastic epithelium along with mucus cell hyperplasia. While the presence of liver lesions were not species or sex-specific, the presence of gill lesions decreased in the order female fourhorn sculpins > female shorthorn sculpins > male fourhorn sculpins > male shorthorn sculpins. Hepatic Hg concentrations exceeded known Lowest Observable Effect Doses (LOED) for fish (0.1-0.5 μg g−1 ww) in 27% of fish, while liver Cd residues in 80% exceeded LOED (0.42-1.8 μg g−1 ww). Based upon these results, data suggest that using the sculpin as a valuable sentinel fish species histopathology may serve as a reliable tool for assessing marine ecosystem exposure to trace metals. However, confounding physiological and ecological factors also need to be considered.
Experimental measurement of nonlinear entanglement witness by hyper-entangling two-qubit states
Creators: name: Trávníček, Vojtěch
name: Bartkiewicz, Karol
name: Černoch, Antonín
name: Lemr, Karel
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We demonstrate that non-linear entanglement witnesses can be made particularly useful for entanglement detection in hyper-entangled or multilevel states. We test this idea experimentally on the platform of linear optics using a hyper-entangled state of two photons. Instead of several simultaneous copies of two-photon entangled states, one can directly measure the witness on single copy of a hyper-entangled state. Our results indicate that hyper-entanglement can be used for quick entanglement detection and it provides a practical testbed for experiments with non-linear entanglement witnesses.
description: 6 pages, 5 figures
The trace anomaly of the (2,0) tensor multiplet in background gauge fields
Creators: name: Manvelyan, R.
name: Petkou, A. C.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the trace anomaly of the (2,0) tensor multiplet in d=6 in the presence of a background SO(5) vector field acting as a source for the R-current. Using both a free-field theory calculation and AdS_7/CFT_6 correspondence, we find that only one of the two possible anomaly structures is non-zero and that its coefficient at strong-coupling differs by the well-known overall factor 4N^3 from the corresponding weak coupling result. We also discuss the relevance of our result to studies of the R-current anomaly in the (2,0) multiplet.
description: 12 pages, LaTeX
Additional file 1 of Association between VTE and antibiotic prophylaxis guideline compliance and patient-reported outcomes after total hip and knee arthroplasty: an observational study
Creators: name: Badge, Helen
name: Churches, Tim
name: Naylor, Justine M.
name: Xuan, Wei
name: Armstrong, Elizabeth
name: Gray, Leeanne
name: Fletcher, John
name: Gosbell, Iain
name: Christine Lin, Chung-Wei
name: Harris, Ian A.
Publisher: name: figshare
Year: 2022
Subjects: Medicine
Neuroscience
Biotechnology
Environmental Sciences not elsewhere classified
Cancer
Mental Health
Hematology

description: Additional file 1. Supplementary Table 1: Criteria for compliance with NHMRC VTE prevention clinical guidelines [26] and Therapeutic Guidelines Antibiotic [27]. Supplementary Table 2: Factors that met criteria for inclusion in regression modelling with Oxford score at 90 days. Supplementary Table 3: Factors that met criteria for inclusion in regression modelling with Oxford score at 365 days. Supplementary Table 4: Factors that met criteria for inclusion in regression modelling with EQ-56D Index scores at 365 days. Supplementary Table 5: Factors that met criteria for inclusion in regression modelling with EQ-56D Index scores at 365 days.
title: Larval development and morphology of six Neotropical poison-dart frogs of the genus Ranitomeya (Anura: Dendrobatidae) based on captive-raised specimens
Creators: name: Klein, Benjamin
name: Regnet, Ruth Anastasia
name: Krings, Markus
name: Rödder, Dennis
Publisher: name: Zoological Research Museum Alexander Koenig
Year: 2020

description: Larval development is a crucial step during the ontogeny of amphibians, concomitantly it is the most sensitive life phase in this group. Due to the complex morphological, physiological and anatomical changes, in addition to their susceptibility to the environment changes, this phase is known as one of the most critical period of development as well as an obstacle in ex-situ breeding programs. Tadpole growth rates can be used to predict the effects of biotic interactions, as well as to predict the survival rate on environmental changes. The assessment of the mortality rate during this phase can be performed using a non-invasive image-based tool, programmed on the open source statistical platform R, SAISAQ (semi-automatic quantification of image-based surface area). It allows analyzing semi-automatically a sequence of stan-dardized image files in order to quantify growth rates. However, the current literature lacks estimates of the larval growth rates for the most species of amphibians, which is also true for species of the genus Ranitomeya Bauer, 1986. Herein, we present the data of the complete larval development of Ranitomeya amazonica (Schulte, 1999), R. benedicta Brown, Twomey, Pepper Sanchez-Rodriguez, 2008, R. imitator (Schulte, 1986), R. reticulata (Boulenger, 1884), R. sirensis (Aichinger, 1991) and R. vanzolinii (Myers, 1982), assisted by photographs, drawings and tables with detailed information about the metamorphosis. In addition, we provide a new larval description for R. benedicta. The results presented here also provide new data of the larval development and morphology for the target species, based on a sample series for each species. With this information, we want to contribute to a better understanding of the group and provide important data to help solve the systematic relationships puzzle. Providing also a baseline to improve further research on captive breeding, our results may have important implications for conservation breeding programs.
title: Affiche de la conférence du projet amorce Fil d'Ariane, ATRI 5
Creators: name: LabexMed
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2017

description: Affiche de la conférence Les territoires de l'absence du projet amorce Fil d'Ariane, ATRI 5, du 27 novembre 2015
description: Relation: http://labexmed.hypotheses.org/1674
$β$-Decay Spectrum, Response Function and Statistical Model for Neutrino Mass Measurements with the KATRIN Experiment
Creators: name: Kleesiek, M.
name: Behrens, J.
name: Drexlin, G.
name: Eitel, K.
name: Erhard, M.
name: Formaggio, J. A.
name: Glück, F.
name: Groh, S.
name: Hötzel, M.
name: Mertens, S.
name: Poon, A. W. P.
name: Weinheimer, C.
name: Valerius, K.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences

description: The objective of the Karlsruhe Tritium Neutrino (KATRIN) experiment is to determine the effective electron neutrino mass $m(ν_\text{e})$ with an unprecedented sensitivity of $0.2\,\text{eV}$ (90\% C.L.) by precision electron spectroscopy close to the endpoint of the $β$ decay of tritium. We present a consistent theoretical description of the $β$ electron energy spectrum in the endpoint region, an accurate model of the apparatus response function, and the statistical approaches suited to interpret and analyze tritium $β$ decay data observed with KATRIN with the envisaged precision. In addition to providing detailed analytical expressions for all formulae used in the presented model framework with the necessary detail of derivation, we discuss and quantify the impact of theoretical and experimental corrections on the measured $m(ν_\text{e})$. Finally, we outline the statistical methods for parameter inference and the construction of confidence intervals that are appropriate for a neutrino mass measurement with KATRIN. In this context, we briefly discuss the choice of the $β$ energy analysis interval and the distribution of measuring time within that range.
description: 27 pages, 22 figures, 2 tables
Oral shedding of herpesviruses in HIV-infected patients with varying degrees of immune status
Creators: name: Chen, H
name: Tamburro, K
name: Sanders, M.K
name: Wade, T.A
name: Napravnik, S
name: Shiboski, C.H
name: Lee, A
name: Webster-Cyriaque, J
name: Aberg, J.A
name: Ghannoum, M
name: Dittmer, D.P
Publisher: name: Lippincott Williams and Wilkins
Year: 2017

description: Objective: Herpesvirus shedding in the oral cavity was analyzed to determine if presence in the oral compartment correlates with systemic changes in HIV-associated immune deficiency as measured by CD4 + cell counts, plasma HIV viral load and presence of AIDS-defining events. Design: A5254 is a multicenter, cross-sectional, single-visit study to evaluate oral complications of HIV/AIDS and determine the association between clinical appearance, herpesvirus shedding, and immune status as ascertained by CD4 + cell count and HIV viral load. In total, 307 HIV-infected individuals were evaluated and throat wash collected. Methods: Fisher's exact test and Kruskal-Wallis test were used to assess the association between presence of herpesviruses and the state of immunodeficiency as stratified by a combination of CD4 + cell count and HIV viral load. Relationship between pathogens and HIV viral load in plasma was modeled by logistic regression. Results: The presence of cytomegalovirus (CMV) and herpes simplex virus-1 in throat wash was associated with decreased CD4 + cell counts. By contrast, Kaposi sarcoma-associated herpesvirus and Epstein-Barr virus were similarly detectable across all levels of CD4 + cell counts. One unit increase in log 10 (HIV viral load) was associated with 1.31 times higher odds of detecting CMV in throat wash when controlling for oral candidiasis, CD4 + cell count, and sites (95% confidence interval 1.04-1.65, P=0.02). Conclusion: Oral CMV shedding was significantly higher in highly immunocompromised HIV + participants. Our finding supports the recommendations to start antiretroviral therapy independent of CD4 + cell count as this may have the added benefit to lower the risk of herpesvirus transmission among persons infected with HIV and their partners.
Signatures of long-range spin-spin interactions in an (In,Ga)As quantum dot ensemble
Creators: name: Fischer, Andreas
name: Evers, Eiko
name: Varwig, Steffen
name: Greilich, Alex
name: Bayer, Manfred
name: Anders, Frithjof B.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We present an investigation of the electron spin dynamics in an ensemble of singly-charged quantum dots subject to an external magnetic field and laser pumping with circularly polarized light. The spectral laser width is tailored such that different groups of quantum dots are coherently pumped. Surprisingly, the dephasing time $T^*$ of the electron spin polarization depends only weakly on the laser spectral width. These findings can be consistently explained by a cluster theory of coupled quantum dots with a long range electronic spin-spin interaction. We present a numerical simulation of the spin dynamics based on the central spin model that includes a quantum mechanical description of the laser pulses as well as a time-independent Heisenberg interaction between each pair of electron spins. We discuss the individual dephasing contributions stemming from the Overhauser field, the distribution of the electron $g$-factors and the electronic spin-spin interaction as well as the spectral width of the laser pulse. This analysis reveals the counterbalancing effect of the total dephasing time when increasing the spectral laser width. On one hand, the deviations of the electron $g$-factors increase. On the other hand, an increasing number of coherently pumped electron spins synchronize due to the spin-spin interaction. We find an excellent agreement between the experimental data and the dephasing time in the simulation using an exponential distribution of Heisenberg couplings with a mean value $\overline{J}\approx 0.26\,\mathrm{μeV}$.
Timing of antiretroviral treatment, immunovirologic status, and TB risk: Implications for testing and treatment
Creators: name: Dowdy, D
name: Jenkins, C
name: Shepherd, B.E
name: Mendes, A
name: Moore, R
name: Freeman, A
name: Pettit, A.C
name: Sterling, T.R
name: Napravnik, S
name: Gill, J
name: Rachlis, A
Publisher: name: Lippincott Williams and Wilkins
Year: 2016

description: Background: Tuberculosis (TB) risk and mortality increase in the 6 months after highly active antiretroviral therapy (HAART) initiation. This short-term risk may be a consequence of HAART initiation and immune reconstitution. Alternatively, it may be due to confounding by low CD4+ counts and high HIV viral loads (VLs). We assessed the TB risk before and after HAART initiation while appropriately controlling for time-updated laboratory values and HAART exposure. Methods: We conducted an observational cohort study among persons enrolled in the North American AIDS Cohort Collaboration on Research and Design from 1998 through 2011. A marginal structural model was constructed to estimate the association of HAART initiation and TB risk. Inverse probability weights for the probability of HAART initiation were incorporated. Results: Among 26,342 patients, 94 cases of TB were diagnosed during 147,557 person-years (p-y) of follow-up. The unadjusted TB rates were 93/100,000 p-y [95% confidence interval (CI): 63 to 132] before HAART initiation, 203/100,000 p-y (95% CI: 126 to 311) ≤6 months after HAART initiation, and 40/100,000 p-y (95% CI: 29 to 55) >6 months on HAART. After controlling for time-updated laboratory values, the adjusted odds of TB ≤6 months after HAART initiation and >6 months was 0.65 (95% CI: 0.28 to 1.51) and 0.29 (95% CI: 0.16 to 0.53), respectively. Conclusions: TB risk in the first 6 months after HAART initiation is not higher than that before HAART initiation after adjusting for CD4+ count and VLs. These findings suggest that short-term TB risk may be related to low CD4+ counts and high VLs near HAART initiation and support early HAART initiation to decrease TB risk.
AGEING@WORK Data Management Plan v.2
Creators: name: Stamos Angelos
name: Claassen Ginger
name: Dubielzig Markus
name: Juan, Bautista Montalvá
name: Zacharaki Evangelia, I.
name: Mockałło Zofia
name: Balla Christina
name: Paliokas Ioannis
name: Wissemann Ann Kathrin
name: Patrick, Serafin
Publisher: name: Zenodo
Year: 2020

description: This deliverable is the second version of the Data Management Plan (DMP) of the Ageing@Work project in accordance with the EC Open Research Data Pilot (ORDP) regulations of the Horizon 2020 programme (H2020) as a living document it will be updated throughout the project. Ageing@Work has received funding from the EU Horizon 2020 Framework Programme for Research and Innovation under Grant Agreement No 826299
Non-Trivial Directions for Scalar Fields
Creators: name: Halpern, Ken
name: Huang, Kerson
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the eigenvectors of the renormalization-group matrix for scalar fields at the Gaussian fixed point, and find that that there exist ``relevant'' directions in parameter space. They correspond to theories with exponential potentials that are nontrivial and asymptotically free. All other potentials, including polynomial potentials, are ``irrelevant,'' and lead to trivial theories. Away from the Gaussian fixed point, renormalization does not induce derivative couplings, but it generates non-local interactions.
description: UUencoded LaTex, 15 pages + 3 postscript figures
A Framework for Decentralised Vehicular Services
Creators: name: Ball, Rudi
Publisher: name: Imperial College London
Year: 2011

description: Traffic management is an old and growing problem within cities with inefficient road use resulting in significant economic costs. Existing traffic management solutions are typically large centralised systems which rely on central authorities for control. Furthermore, these systems are costly to setup, deploy and maintain. Within the near future it is expected that Vehicle-to-X (V2X) technologies will become integrated into both vehicles and transportation infrastructures. V2X technologies allow vehicles and road-side infrastructure to communicate with one another using ad-hoc wireless communications. In this thesis we present a unique vehicular framework for the development and prototyping of decentralised vehicular services which exploit available V2X technologies. The framework uses discrete event simulation to evaluate the operation of a decentralised vehicular service. The decentralised services presented within the thesis are unique as they require a combination of scaled ad-hoc inter-vehicle messaging, mobility data and cooperation to enable communities of road vehicles to provide services to one another. Vehicles manage themselves in their local space to approximate the outcomes of centralised services. As vehicular services are decentralised they reduce the costs associated with deploying and supporting traffic services. Using the framework we prototype two novel decentralised traffic control protocols which evaluate the problems of travel time estimation and intersection control. Each protocol is evaluated in a scaled scenario which emphasises the usage and requirement of fine grained geographic mobility traces which mimic real city road maps. We show that decentralised approaches provide a feasible means of providing vehicular services to users. We evaluate the trade-offs and performance issues resulting from their use.
The Color-Magnitude Relation in CL 1358+62 at z=0.33: Evidence for Significant Evolution in the S0 Population
Creators: name: van Dokkum, Pieter G.
name: Franx, Marijn
name: Kelson, Daniel D.
name: Illingworth, Garth D.
name: Fisher, David
name: Fabricant, Daniel
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We use a large mosaic of HST WFPC2 images to measure the colors and morphologies of 194 spectroscopically confirmed members of the rich galaxy cluster CL1358+62 at z=0.33. We study the color-magnitude (CM) relation as a function of radius in the cluster. The intrinsic scatter in the restframe B-V CM relation of the elliptical galaxies is very small: ~0.022 magnitudes. The CM relation of the ellipticals does not depend significantly on the distance from the cluster center. In contrast, the CM relation for the S0 galaxies does depend on radius: the S0s in the core follow a CM relation similar to the ellipticals, but at large radii (R>0.7Mpc) the S0s are systematically bluer and the scatter in the CM relation approximately doubles to ~0.043 magnitudes. The blueing of the S0s is significant at the 95% confidence level. These results imply that the S0 galaxies in the outer parts of the cluster have formed stars more recently than the S0s in the inner parts. A likely explanation is that clusters at z=0.33 continue to accrete galaxies and groups from the field and that infall extinguishes star formation. The apparent homogeneity of the elliptical galaxy population implies that star formation in recently accreted ellipticals was terminated well before accretion occurred. We have constructed models to explore the constraints that these observations place on the star formation history of cluster galaxies. We conclude that the population of S0s in clusters is likely to evolve as star forming galaxies are converted into passively evolving galaxies. Assuming a constant accretion rate after z=0.33, we estimate ~15% of the present day early-type galaxy population in rich clusters was accreted between z=0.33 and z=0. The ellipticals (and the brightest S0s) are probably a more stable population, at least since z=0.6.
description: Accepted for publication in the ApJ. 20 pages, 12 figures. Full version and plates available at http://www.astro.rug.nl/~dokkum/papers.html
title: Transcriptions Cisterciens et Ressources #76
Creators: name: Arribet-Deroin, Danielle
name: Arribet-Deroin, Danielle
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021
Subjects: subject: carrière
subject: bois
subject: écluse
subject: four
subject: minière
subject: moulin
subject: étang
subject: vivier
subject: LaMOP
subject: jardin
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: verger
subject: moulin foulon
subject: moulin battant

description: Amédée, évêque de Besançon, confirme une longue liste de donations, parmi lesquelles celles du seigneur Guy de la Roche.
description: Source: A. Vesoul, Arch. dép. de la Haute-Saône, H 183 liasses
description: Source: B. Vesoul, Arch. dép. de la Haute-Saône, H 47/3 (copie 1645)
description: Source: C. Vesoul, Arch. dép. de la Haute-Saône, H 185 (copie partielle insérée dans le procès-verbal de 1647)
description: Source: a. Benoît Chauvin, « Documents franc-comtois (1186-1349) pour servir à l’histoire de la sidérurgie cistercienne au Moyen Âge », dans Mélanges à la mémoire du père Anselme Dimier, t. II, vol. 3, Pupillin, 1984, p. 63-71, aux p. 67-68.
description: Relation: https://cisterciensetressources.lamop.fr/
description: Bibliographic citation: Transcription CIS#76, Danielle Arribet-Deroin, in Projet Cisterciens et Ressources [Ressource en ligne], https://cisterciensetressources.lamop.fr/
description: Transcription Cisterciens et Ressources #76
Evaluating the cost-effectiveness of secukinumab in moderate to severe psoriasis: a Japanese perspective
Creators: name: Atsuyuki Igarashi
name: Igarashi, Ataru
name: Graham, Christopher N.
name: Gilloteau, Isabelle
name: Tani, Yumiko
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Aim: To evaluate the cost-effectiveness of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, compared to other clinically used biologics (adalimumab, infliximab, and ustekinumab) in Japan for the treatment of moderate to severe psoriasis from the healthcare system (total costs) and patient co-payment (using different frequencies of drug purchase) perspectives. Methods: A decision-tree (first year)/Markov model (subsequent years), with an annual cycle, was developed. The model adopted a 5-year time horizon. Efficacy inputs were obtained from a mixed-treatment comparison analysis and other model inputs were collected from published literature and local Japanese sources. Model outcomes included quality-adjusted life years (QALYs) and incremental cost-effectiveness ratio (ICER) in terms of cost per QALY gained. The annual discounting rate of 2% was applied to both costs and outcomes. Results: Results for the healthcare system perspective showed that secukinumab had the highest number of quality-adjusted life years (QALYs) (4.07) versus other biologics, dominated ustekinumab and infliximab, and the ICER of secukinumab compared to adalimumab was ¥8,418,222/QALY gained. In the patient co-payment perspective with the monthly purchase of drugs, ustekinumab had the lowest co-payment cost, followed by infliximab, adalimumab, and secukinumab. In the patient co-payment perspective with once every three months purchase of secukinumab and adalimumab, the co-payment costs of secukinumab, adalimumab, and ustekinumab became comparable, and infliximab had highest co-payment cost. Limitations: Only short-term efficacy data was modeled, as there was a lack of data on long-term outcomes. Treatment sequencing was restricted to first-line biologic treatment. Drop-out rates for comparators were assumed to be equivalent to secukinumab in the absence of available data. Conclusions: Secukinumab is a cost-efficient treatment for moderate to severe psoriasis, providing greater health outcomes to patients at lower total costs compared to infliximab and ustekinumab, as well as comparable patient co-payment relative to other biologic treatments.