cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Water Networks In Drug Design
Creators: name: Frye, Leah
Publisher: name: Zenodo
Year: 2015

description: Water plays a key role in the binding of small molecules to proteins and thus, for drug design, it is critical to have a clear understanding of active site water networks. Molecular dynamics simulations coupled with clustering and statistical thermodynamics allow for the prediction of the enthalpy, entropy and free energy of binding site waters. The energetics of these waters provide information on the druggability of the site and the locations of 'hot spots' which can be targeted in virtual screening and lead optimization. Using the enthalpic and entropic terms, it is possible to determine which waters should be displaced with a hydrophobic group, replaced with a water mimetic, or avoided to improve potency providing a 3D roadmap for the design of ligands with improved potency and selectivity. Once compounds have been designed, free energy perturbation methods can be used to prioritize compounds for synthesis. This talk will provide examples, both retrospective and prospective, of the successful use of binding site water energetics to evaluate druggability, identify 'hot spots', assess opportunities for use of bridging waters, and facilitate the design of compounds with improved potency and selectivity. The discussion will include details on the use of these approaches in a program involving identification of lead compounds viavirtual screening followed by rapid optimization to a development candidate that has progressed into clinical trials.
The new Cold Neutron Chopper Spectrometer at the Spallation Neutron Source - Design and Performance
Creators: name: Ehlers, G.
name: Podlesnyak, A.
name: Niedziela, J. L.
name: Iverson, E. B.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: The design and performance of the new Cold Neutron Chopper Spectrometer (CNCS) at the Spallation Neutron Source in Oak Ridge are described. CNCS is a direct geometry inelastic time-of-flight spectrometer, designed to cover essentially the same energy and momentum transfer ranges as IN5 at ILL, LET at ISIS, DCS at NIST, TOFTOF at FRM2, AMATERAS at J-PARC, PHAROS at LANSCE and NEAT at HZB, at similar energy resolution. Measured values of key figures such as neutron flux at sample position and energy resolution are compared between measurements and ray tracing Monte Carlo simulations, and good agreement (better than 20% of absolute numbers) has been achieved. The instrument performs very well in the cold and thermal neutron energy ranges, and promises to become a workhorse for the neutron scattering community for quasielastic and inelastic scattering experiments.
Additional file 1 of Low-intensity pulsed ultrasound promotes mesenchymal stem cell transplantation-based articular cartilage regeneration via inhibiting the TNF signaling pathway
Creators: name: Chen, Yiming
name: Yang, Huiyi
name: Wang, Zhaojie
name: Zhu, Rongrong
name: Cheng, Liming
name: Cheng, Qian
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1 Table S1: Lists of hUC-MSCs qPCR primers. Table S2: Lists of C28/I2 qPCR primers
Collaborative Drug Discovery At The European Lead Factory
Creators: name: Pannifer, Andrew
Publisher: name: Zenodo
Year: 2015

description: The European Lead Factory (ELF) is a public-private consortium aimed at delivering high quality hit compounds against novel biological targets proposed by academic labs or SMEs across Europe. The ELF has built an HTS library (the JECL), initially with 327,000 compounds contributed by the seven pharma companies in the consortium and will expand to around 500,000 compounds. Screening and characterisation are carried out at the ELF's HTS labs and the results are triaged using a suite of cheminformatic and management tools (the HDB) that enable accurate compound selection while safeguarding the IP of all the partners.
I will describe two key aspects that were essential for the consortium:
(1) The construction of the JECL HTS library using subsets contributed by multiple pharma companies, without requiring the companies to divulge compound structures.
(2) the HDB; a new triage system that regulates access to compound structures while providing all the tools and information required for a high quality HTS triage and management of the project.
Mareike von Müller: Schwarze Komik
Creators: name: Rippl, Coralie
Publisher: name: Das Mittelalter. Perspektiven mediävistischer Forschung
Year: 2022

description: Mareike von Müller, Schwarze Komik. Narrative Sinnirritationen zwischen Märe und Schwank (Studien zur historischen Poetik 24). Winter, Heidelberg 2017. 381 S.
description: Das Mittelalter. Perspektiven mediävistischer Forschung, Bd. 27 Nr. 2 (2022): Die Materialität von Kredit. Sachüberlieferungen mittelalterlicher Schuld- und Kreditbeziehungen
The Acetogenin Based Bis-Tetrahydropyran 1,4-Triazole, Jm425, Is Trypoanocidal Through Inhibition Of Mitochondrial Complex V
Creators: name: Tulloch, Lindsay
Publisher: name: Zenodo
Year: 2015

description: The acetogenin family of polyketides produced by annonaceacous plants has broad anti-microbial activity through its potent inhibition of mitochondrial complex I. We recently reported the trypanocidal activity of a series of novel synthetic bis-tetrahydropyran 1,4-triazole analogues based on the framework of the acetogenin chamuvarinin. These compounds are active against both bloodstream and procyclic (insect) forms ofTrypanosoma brucei, the parasite responsible for African sleeping sickness, also known as Human African Trypanosomiasis (HAT). However the bloodstream form lacks mitochondrial complex I activity so we undertook a series of biological analyses to identify the target of our bis-tetrahydropyran 1,4-triazoles in T. brucei. Using a luciferase-based ATP quantitation assay we show that our lead compound, JM425, reduces cellular ATP production from proline metabolism in the procyclic form. JM425 ablates oxidative phosphorylation in isolated procyclic form mitochondria, but has little effect on substrate-level ATP production, indicating JM425 specifically inhibits one of mitochondrial respiration complexes III-V. Imaging with MitoTracker dye revealed that JM425 elevates the mitochondrial membrane potential in the procyclic form, consistent with inhibition of mitochondrial complex V, the F0F1-ATP synthase. For final confirmation, dual inhibitor studies using JM425 and other inhibitors of oxidative phosphorylation reveal that JM425 works synergistically with the complex III inhibitor antimycin A, but additively with complex V inhibitor oligomycin A. Complex V is essential for both bloodstream and procyclic T. brucei and is an attractive drug target. With the target of our bis-tetrahydropyran 1,4-triazoles identified as mitochondrial complex V a structure-based approach can be used to optimize inhibitor potency and specificity.
Black holes dual to helical current phases
Creators: name: Donos, Aristomenis
name: Gauntlett, Jerome P.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider the class of d=4 CFTs at finite temperature and chemical potential that are holographically described within D=5 Einstein-Maxwell theory with a Chern-Simons term. The high temperature phase, which is spatially homogeneous and isotropic, is dual to the AdS-Reissner-Nordstrom black brane solution. For sufficiently large Chern-Simons coupling, we construct new electrically charged AdS black hole solutions that are dual to the low temperature, spatially modulated phase. In this phase the current, associated with the abelian global symmetry, spontaneously acquires a helical order. The new black holes are stationary and also have Bianchi VII$_0$ symmetry.
description: 23 pages, 10 figures
Chemoproteomic Approaches For Epigenetic Drug Targets
Creators: name: G?Rard Joberty
Publisher: name: Zenodo
Year: 2015

description: Chemoproteomics has been successfully developed in the recent years as an alternative drug discovery tool to more traditional approaches using often isolated recombinant drug targets. It combines affinity-based capturing of compound targets and proteomics analysis in close-to-physiological conditions aiming at preserving protein complexes and post-translational modifications (PTMs). These features are particularly of importance when studying epigenetic drug targets that are most often part of large protein complexes which composition and function are regulated by the presence of a variety of PTMs.
This presentation is aiming at presenting different complementary chemoproteomic strategies that have been used in epigenetic programs. In the first example, we report how the discovery of BET inhibitors has paved the way to demonstrate that members of the family of BROMO domain containing proteins are genuine drug targets. In a second example, taken this time from the HDAC family of deacetylases, we take advantage of chemoproteomics to show that some HDAC inhibitors display target and protein complex selectivity. In the case of slow-binding inhibitors, this selectivity is dependent on duration and dosing.
Novel Bet Bromodomain Inhibitors For Cardiovascular And Inflammatory Disease
Creators: name: Kempen, Herman
Publisher: name: Zenodo
Year: 2015

description: Cardiovascular diseases are still the major cause of morbidity and mortality in developed countries, and are strongly on the increase in developing countries. Major cause of cardiovascular diseases is atherosclerosis in the arteries supplying blood to heart, brain and legs. BET bromodomain proteins are key players in epigenetic regulation of gene expression,and are emerging as promising drug targets for multiple indications. Dybly is working on small molecules able to potently upregulate hepatic apoA-I production, increasing reverse cholesterol and so able to reduce atherosclerotic plaque burden. Our molecules recently emanated to be selective BET bromodomain inhibitors. We then started a medchem effort to obtain more potent derivatives, and succeeded in gaining a 100-fold increase in potency in apoA-I upregulation. Their broader anti-inflammatory potential was demonstrated by promising reductions of IL-6 release by cultured macrophages and reduction of tissue swelling after LPS administration in vivo. This opens the opportunity to develop these compounds for diseases like rheumatoid arthritis, inflammatory bowel diseases, asthma, or atopic dermatitis.
Katharina Preißler: Fromme Lieder – Heilige Bilder
Creators: name: Schmidt, Andreas
Publisher: name: Das Mittelalter. Perspektiven mediävistischer Forschung
Year: 2022

description: Katharina Preißler, Fromme Lieder – Heilige Bilder. Intermediale Perspektiven auf die skandinavische Ballade und die spätmittelalterliche Bildkunst Schwedens und Dänemarks (Münchner Nordistische Studien 36). München, utzverlag 2019. 452 S. 37 Abb.
description: Das Mittelalter. Perspektiven mediävistischer Forschung, Bd. 27 Nr. 2 (2022): Die Materialität von Kredit. Sachüberlieferungen mittelalterlicher Schuld- und Kreditbeziehungen
Ilka Mestemacher: Marmor, Gold und Edelsteine
Creators: name: Rombach, Ursula
Publisher: name: Das Mittelalter. Perspektiven mediävistischer Forschung
Year: 2022

description: Ilka Mestemacher, Marmor, Gold und Edelsteine. Materialimitation in der karolingischen Buchmalerei (Naturbilder. Images of Nature 11). Berlin, Boston, De Gruyter 2021. 392 S. 167 Abb.
description: Das Mittelalter. Perspektiven mediävistischer Forschung, Bd. 27 Nr. 2 (2022): Die Materialität von Kredit. Sachüberlieferungen mittelalterlicher Schuld- und Kreditbeziehungen
Additional file 2 of Low-intensity pulsed ultrasound promotes mesenchymal stem cell transplantation-based articular cartilage regeneration via inhibiting the TNF signaling pathway
Creators: name: Chen, Yiming
name: Yang, Huiyi
name: Wang, Zhaojie
name: Zhu, Rongrong
name: Cheng, Liming
name: Cheng, Qian
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2 Figure S1: Representative Alcian blue staining images for the chondrocyte spheres in suspension culture for LIPUS stimulation and adhered for staining. Figure S2: Western blot data of chondrogenic proteins (COL-II, ACAN, and SOX-9) and actin after different parameters of LIPUS stimulation
Stefan Matter: Tagzeitentexte des Mittelalters
Creators: name: Ubl, Linus
Publisher: name: Das Mittelalter. Perspektiven mediävistischer Forschung
Year: 2022

description: Stefan Matter, Tagzeitentexte des Mittelalters. Untersuchungen und Texte zur deutschen Gebetbuchliteratur (Liturgie und Volkssprache 4). Berlin, Boston, De Gruyter 2021. X, 356 S. 22 Abb.
description: Das Mittelalter. Perspektiven mediävistischer Forschung, Bd. 27 Nr. 2 (2022): Die Materialität von Kredit. Sachüberlieferungen mittelalterlicher Schuld- und Kreditbeziehungen
Wolfgang Lenzen: Abaelards Logik
Creators: name: Rode, Christian
Publisher: name: Das Mittelalter. Perspektiven mediävistischer Forschung
Year: 2022

description: Wolfgang Lenzen, Abaelards Logik. Leiden, Paderborn, Brill/mentis 2021. XIV, 206 S. 7 Abb. 18 Tab.
description: Das Mittelalter. Perspektiven mediävistischer Forschung, Bd. 27 Nr. 2 (2022): Die Materialität von Kredit. Sachüberlieferungen mittelalterlicher Schuld- und Kreditbeziehungen
Multi-color observations of short GRB afterglows: 20 events observed between 2007 and 2010
Creators: name: Guelbenzu, A. Nicuesa
name: Klose, S.
name: Greiner, J.
name: Kann, D. A.
name: Kruehler, T.
name: Rossi, A.
name: Schulze, S.
name: Afonso, P. M. J.
name: Elliott, J.
name: Filgas, R.
name: Hartmann, D. H.
name: Yoldas, A. Kuepcue
name: McBreen, S.
name: Nardini, M.
name: E., F. Olivares
name: Rau, A.
name: Schmidl, S.
name: Schady, P.
name: Sudilovsky, V.
name: Updike, A. C.
name: Yoldas, A.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We report on follow-up observations of 20 short-duration gamma-ray bursts performed in g'r'i'z'JHKs with the seven-channel imager GROND between mid-2007 and the end of 2010. This is one of the most comprehensive data sets on GRB afterglow observations of short bursts published so far. In three cases GROND was on target within less than 10 min after the trigger, leading to the discovery of the afterglow of GRB 081226A and its faint underlying host galaxy. In addition, GROND was able to image the optical afterglow and follow the light-curve evolution in further five cases, GRBs 090305, 090426, 090510, 090927, and 100117A. In all other cases optical/NIR upper limits can be provided on the afterglow magnitudes.
description: 19 pages, 17 figures, submitted to Astronomy & Astrophysics
Beate Kellner, Susanne Reichlin u. Alexander Rudolph (Hgg.): Handbuch Minnesang
Creators: name: Emmerling, Sonja
Publisher: name: Das Mittelalter. Perspektiven mediävistischer Forschung
Year: 2022

description: Beate Kellner, Susanne Reichlin u. Alexander Rudolph (Hgg.), Handbuch Minnesang. Berlin, Boston, De Gruyter 2021. 845 S. 24 Abb.
description: Das Mittelalter. Perspektiven mediävistischer Forschung, Bd. 27 Nr. 2 (2022): Die Materialität von Kredit. Sachüberlieferungen mittelalterlicher Schuld- und Kreditbeziehungen
Spaces of measurable functions
Creators: name: Niemiec, Piotr
Publisher: name: arXiv
Year: 2011
Subjects: subject: General Topology (math.GN)
subject: FOS: Mathematics
subject: 54C35, 54C55, 54H05, 57N20, 58D15

description: For a metrizable space $X$ and a finite measure space $(Ω,\mathfrak{M},μ)$ let $M_μ(X)$ and $M^f_μ(X)$ be the spaces of all equivalence classes (under the relation of equality almost everywhere mod $μ$) of $mathfrak{M}$-measurable functions from $Ω$ to $X$ whose images are separable and finite, respectively, equipped with the topology of convergence in measure. The main aim of the paper is to prove the following result: if $μ$ is (nonzero and) nonatomic and $X$ has more than one point, then the space $M_μ(X)$ is a noncompact absolute retract and $M^f_μ(A)$ is homotopy dense in $M_μ(X)$ for each dense subset $A$ of $X$. In particular, if $X$ is completely metrizable, then $M_μ(X)$ is homeomorphic to an infinite-dimensional Hilbert space.
description: 22 pages
Additional file 3 of Low-intensity pulsed ultrasound promotes mesenchymal stem cell transplantation-based articular cartilage regeneration via inhibiting the TNF signaling pathway
Creators: name: Chen, Yiming
name: Yang, Huiyi
name: Wang, Zhaojie
name: Zhu, Rongrong
name: Cheng, Liming
name: Cheng, Qian
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3 Full-length blots of the data shown in Figure S2.
Hauke Horn u. Matthias Müller (Hgg.): Gotische Architektur am Mittelrhein
Creators: name: Waschbüsch, Andreas
Publisher: name: Das Mittelalter. Perspektiven mediävistischer Forschung
Year: 2022

description: Hauke Horn u. Matthias Müller (Hgg.), Gotische Architektur am Mittelrhein. Regionale Vernetzung und überregionaler Anspruch (Phoenix. Mainzer Kunstwissenschaftliche Bibliothek 5). Berlin, Boston, De Gruyter 2020. 371 S. 312 s/w-Abb., 48 farb. Abb.
description: Das Mittelalter. Perspektiven mediävistischer Forschung, Bd. 27 Nr. 2 (2022): Die Materialität von Kredit. Sachüberlieferungen mittelalterlicher Schuld- und Kreditbeziehungen
Thomas Honegger: Introducing the Medieval Dragon
Creators: name: Wackers, Paul
Publisher: name: Das Mittelalter. Perspektiven mediävistischer Forschung
Year: 2022

description: Thomas Honegger, Introducing the Medieval Dragon. Cardiff, University of Wales Press 2019. 169 S. 15 Abb.
description: Das Mittelalter. Perspektiven mediävistischer Forschung, Bd. 27 Nr. 2 (2022): Die Materialität von Kredit. Sachüberlieferungen mittelalterlicher Schuld- und Kreditbeziehungen
Joachim Heinzle: Wolfram von Eschenbach
Creators: name: Schöller, Robert
Publisher: name: Das Mittelalter. Perspektiven mediävistischer Forschung
Year: 2022

description: Joachim Heinzle, Wolfram von Eschenbach. Dichter der ritterlichen Welt. Leben, Werke, Nachruhm. Basel, Schwabe 2019. 334 S. 32 Abb.
description: Das Mittelalter. Perspektiven mediävistischer Forschung, Bd. 27 Nr. 2 (2022): Die Materialität von Kredit. Sachüberlieferungen mittelalterlicher Schuld- und Kreditbeziehungen
RCW 86: A Type Ia Supernova in a Wind-Blown Bubble
Creators: name: Williams, Brian J.
name: Blair, William P.
name: Blondin, John M.
name: Borkowski, Kazimierz J.
name: Ghavamian, Parviz
name: Long, Knox S.
name: Raymond, John C.
name: Reynolds, Stephen P.
name: Rho, Jeonghee
name: Winkler, P. Frank
Publisher: name: arXiv
Year: 2011
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We report results from a multi-wavelength analysis of the Galactic SNR RCW 86, the proposed remnant of the supernova of 185 A.D. We report new infrared observations from {\it Spitzer} and {\it WISE}, where the entire shell is detected at 24 and 22 $μ$m. We fit the infrared flux ratios with models of collisionally heated ambient dust, finding post-shock gas densities in the non-radiative shocks of 2.4 and 2.0 cm$^{-3}$ in the SW and NW portions of the remnant, respectively. The Balmer-dominated shocks around the periphery of the shell, large amount of iron in the X-ray emitting ejecta, and lack of a compact remnant support a Type Ia origin for this remnant. From hydrodynamic simulations, the observed characteristics of RCW 86 are successfully reproduced by an off-center explosion in a low-density cavity carved by the progenitor system. This would make RCW 86 the first known case of a Type Ia supernova in a wind-blown bubble. The fast shocks ($> 3000$ km s$^{-1}$) observed in the NE are propagating in the low-density bubble, where the shock is just beginning to encounter the shell, while the slower shocks elsewhere have already encountered the bubble wall. The diffuse nature of the synchrotron emission in the SW and NW is due to electrons that were accelerated early in the lifetime of the remnant, when the shock was still in the bubble. Electrons in a bubble could produce gamma-rays by inverse-Compton scattering. The wind-blown bubble scenario requires a single-degenerate progenitor, which should leave behind a companion star.
description: Accepted for publication in ApJ. 50 pages, 9 figures
Additional file 1 of Unlocking the potential of TIPS placement as a bridge to elective and emergency surgery in cirrhotic patients: a meta-analysis and future directions for endovascular resuscitation in acute care surgery
Creators: name: Manzano-Nunez, Ramiro
name: Jimenez-Masip, Alba
name: Chica-Yanten, Julian
name: Ibn-Abdelouahab, Abdelaziz
name: Sartelli, Massimo
name: de’Angelis, Nicola
name: Moore, Ernest E.
name: García, Alberto F.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1. Supplementary File.
Jeffrey F. Hamburger: Color in Cusanus
Creators: name: Mandrella, Isabelle
Publisher: name: Das Mittelalter. Perspektiven mediävistischer Forschung
Year: 2022

description: Jeffrey F. Hamburger, Color in Cusanus. Stuttgart, Hiersemann 2021. 199 S. 42 Abb.
description: Das Mittelalter. Perspektiven mediävistischer Forschung, Bd. 27 Nr. 2 (2022): Die Materialität von Kredit. Sachüberlieferungen mittelalterlicher Schuld- und Kreditbeziehungen
Yasemin Gökpinar: Der „ṭarab" der Sängersklavinnen
Creators: name: Kollatz, Anna
Publisher: name: Das Mittelalter. Perspektiven mediävistischer Forschung
Year: 2022

description: Yasemin Gökpinar, Der ṭarab der Sängersklavinnen. Masālik al-abṣār fī mamālik al-amṣār von Ibn Faḍlallāh al-ʿUmarī (gest. 749/1349). Textkritische Edition des 10. Kapitels Ahl ʿilm al-mūsīqī mit kommentierter Übersetzung (Bibliotheca Academia Orientalistik 33). Baden-Baden, Ergon 2021. 350 S.
description: Das Mittelalter. Perspektiven mediävistischer Forschung, Bd. 27 Nr. 2 (2022): Die Materialität von Kredit. Sachüberlieferungen mittelalterlicher Schuld- und Kreditbeziehungen
Special 6j and 9j symbols for a single-j shell
Creators: name: Pain, Jean-Christophe
Publisher: name: arXiv
Year: 2011
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: In this Brief Report, we propose general expressions for 6j and 9j coefficients arising in the study of the J-pairing interaction of identical fermions in a single-j shell. In the literature such coefficients are available only for a number of given angular momenta.
description: submitted to "Phys. Rev. C"
Irradiation Enhanced paramagnetism on graphene nanoflakes
Creators: name: Ney, Andreas
name: Papakonstantinou, Pagona
name: Kumar, Ajay
name: Shang, Nai-Gui
name: Peng, Nianhua
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We have studied the magnetization of vertically aligned graphene nanoflakes irradiated with nitrogen ions of 100 KeV energy and doses in the range 10^11- 10^17 ions/cm2. The non-irradiated graphene nanoflakes show a paramagnetic contribution, which is increased progressively by ion irradiation at low doses up to 10^15 /cm^2. However, further increase on implantation dose reduces the magnetic moment which coincides with the onset of amorphization as verified by both Raman and X-ray photoelectron spectroscopic data. Overall, our results demonstrate the absence of ferromagnetism on either implanted or unimplanted samples from room temperature down to a temperature of 5K
description: Corresponding authors: p.papakonstantinou@ulster.ac.uk; andreas.ney@uni-due.de
Additional file 1 of T-RHEX-RNAseq – a tagmentation-based, rRNA blocked, random hexamer primed RNAseq method for generating stranded RNAseq libraries directly from very low numbers of lysed cells
Creators: name: Gustafsson, Charlotte
name: Hauenstein, Julia
name: Frengen, Nicolai
name: Krstic, Aleksandra
name: Luc, Sidinh
name: Månsson, Robert
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Figure S1. Schematic overview of the T-RHEX-RNAseq protocol outlining adapters, adapter introduction and primers used to amplify the library. In brief, double stranded cDNA reverse transcription with dUTP incorporated during the second strand synthesis is subjected to tagmentation with Tn5 loaded with i5 adapters. The i7 adapters are introduced by annealing an i7 oligo to the covalently attached part of the i5 adapter. Subsequently, gap fill in combination with ligation is used to covalently attach the i7 adapter. As Phusion is unable to utilize the dUTP containing strand as a template, stranded libraries are then generated by amplification using Pr2 in combination with the i5 completion primer. Figure S2. Strand-specificity of Tn-RNAseq and Directional Tn-RNAseq libraries. (A). Percentage of reads in exons: localized in a matched or mismatched orientation to transcript; or alternatively being localized in regions with overlapping antiparallel transcripts (undetermined). The data from Gertz et al., [1] was downloaded and processed using nf-core and strand-specificity evaluated using RSeq QC. Figure S3. Tracks and duplication rates of T-RHEX-RNAseq libraries from primary hematopoietic stem- and progenitor cells. (A) Tracks showing plus and minus strand reads in the Neat1, Kit, Hspd1 and Hspe1 genomic regions in primary mouse hematopoietic stem cells (HSCs) and lymphoid primed multipotent progenitors (LMPPs). Arrows below the gene names indicate the 5’-3’ direction of the transcript. RNAseq libraries were prepared directly from the indicated numbers of cells lysed in Single cell lysis solution (SCLS). The use of rRNA blocking reagents and dilution of the blocking reagent is indicated in parenthesis. (B) Reoccurrence (duplication rates) of reads in the indicated libraries. Figure S4. T-RHEX-RNAseq provides highly reproducible data. Spearman correlation between rlog of gene expression in samples generated from the indicated population. The use of rRNA blocking reagents and dilution of the blocking reagent is indicated in parenthesis. Hematopoietic stem cell (HSC with or without CD49b expression); Multipotent progenitor (MPP with no or low CD150 expression), lymphoid primed multipotent progenitors (LMPPs); granulocyte/monocyte progenitors (GMP); and antigen specific CD4 T cells (T, from wild-type or Bhlhe40 knockout mice). Data is from proof-of-principle experiments (HSC and LMPP; 250 and 500 cells respectively) or the subsequently generated T-RHEX-RNAseq data from antigen specific CD4 T cells (1000 cells) [1] and hematopoietic stem/progenitor cells (HSPCs; 250-500 cells) [2]. Table S1. Sample metrics and QC. Supplemental working protocol.
title: "Trapezoforo, sezione", arte romana, inv. CCXXVIa (ITA/EN)
title: Scheda catalogo digitale Borghese
titleType: AlternativeTitle
Creators: name: Clementi, Jessica
name: Galleria Borghese
Publisher: name: Galleria Borghese
Year: 2024

description: Pubblicazione delle schede delle opere conservate nel museo ed estratte dal catalogo digitale di

Galleria Borghese, nelle due versioni esistenti online, in italiano e inglese.

Collegamento al catalogo digitale:

ITA: https://www.collezionegalleriaborghese.it/

EN: https://www.collezionegalleriaborghese.it/en
Analyzing flow anisotropies with excursion sets in relativistic heavy-ion collisions
Creators: name: Mohapatra, Ranjita K.
name: Saumia, P. S.
name: Srivastava, Ajit M.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We show that flow anisotropies in relativistic heavy-ion collisions can be analyzed using a certain technique of shape analysis of excursion sets recently proposed by us for CMBR fluctuations to investigate anisotropic expansion history of the universe. The technique analyzes shapes (sizes) of patches above (below) certain threshold value for transverse energy/particle number (the excursion sets) as a function of the azimuthal angle and rapidity. Modeling flow by imparting extra anisotropic momentum to the momentum distribution of particles from HIJING, we compare the resulting distributions for excursion sets at two different azimuthal angles. Angles with maximum difference in the two distributions identify the event plane, and the magnitude of difference in the two distributions relates to the magnitude of momentum anisotropy, i.e. elliptic flow.
description: 5 pages, 4 figures
Additional file 1 of Efficacy and safety of Lenzumestrocel (Neuronata-R® inj.) in patients with amyotrophic lateral sclerosis (ALSUMMIT study): study protocol for a multicentre, randomized, double-blind, parallel-group, sham procedure-controlled, phase III trial
Creators: name: Nam, Jae-Yong
name: Lee, Tae Yong
name: Kim, Kwijoo
name: Chun, Sehwan
name: Kim, Min Sung
name: Shin, Jin-Hong
name: Sung, Jung-Joon
name: Kim, Byoung Joon
name: Kim, Byung-Jo
name: Oh, Ki-Wook
name: Kim, Kyung Suk
name: Kim, Seung Hyun
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1.
title: Camelia :
title: Directrices para la ejecución del examen de la distinción, la homogeneidad y la estabilidad.
titleType: Subtitle
Creators: name: International Union For The Protection Of New Varieties Of Plants,
Publisher: name: International Union for the Protection of New Varieties of Plants,
Year: 0
Subjects: Plants
New Varieties of Plants
Camellia

description: La finalidad de estas directrices (“directrices de examen”) es elaborar los principios que figuran en la Introducción General (documento TG/1/3) y sus documentos TGP conexos, con objeto de que sirvan de orientación práctica y detallada para el examen armonizado de la distinción, homogeneidad y estabilidad (DHE) y en particular, para identificar los caracteres apropiados para el examen DHE y producir descripciones armonizadas de variedades.
Gesine Güldemund: Das Erbrecht der Buch’schen Glosse
Creators: name: Hirscher, Constanze
Publisher: name: Das Mittelalter. Perspektiven mediävistischer Forschung
Year: 2022

description: Gesine Güldemund, Das Erbrecht der Buch’schen Glosse (Forschungen zur Deutschen Rechtsgeschichte 35). Köln, Böhlau 2021. 693 S. 6 Abb. 19 Graphiken.
description: Das Mittelalter. Perspektiven mediävistischer Forschung, Bd. 27 Nr. 2 (2022): Die Materialität von Kredit. Sachüberlieferungen mittelalterlicher Schuld- und Kreditbeziehungen
Additional file 1 of Progestins in the symptomatic management of endometriosis: a meta-analysis on their effectiveness and safety
Creators: name: Mitchell, Jon-Benay
name: Chetty, Sarentha
name: Kathrada, Fatima
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy

description: Additional file 1. PRISMA Checklist Tool.
Single-Cell Resolution Of Emergent Clones In The Myelodysplastic Syndromes During Therapy And Disease Progression
Creators: name: Vijay, Priyanka
Publisher: name: Zenodo
Year: 2015

description: The myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis and increased risk of progression to acute myeloid leukemia. The DNA methyltransferase inhibitor, decitabine, elicits initial responses in 40-50% of patients through poorly understand mechanisms, but ultimately all patients progress. We previously showed that hematopoietic stem cells (HSCs) are the disease-initiating cells in MDS, and therefore hypothesized that HSC heterogeneity can explain the variable clinical outcomes and therapy resistance in MDS patients. To characterize the heterogeneity of MDS HSCs, we performed single-cell RNA sequencing of HSCs from paired pre-/ post-decitabine samples as well as samples from untreated MDS patients and age-matched normal controls. The sequencing data was of high quality, with an average of 80% mapped reads. Our analysis reveals that principal components analysis (PCA) and hierarchical clustering of MDS HSC single cell transcriptomes perfectly separate patients. We also observed several hundred transcripts to be heterogeneously expressed within a sample. In addition, comparison of paired pre-/post-decitabine MDS HSCs identified hundreds of differentially expressed genes (FDR< 0.01) in decitabine responders that comprised Gene Ontology categories of ?nuclear-transcribed mRNA catabolic process, nonsense mediated decay? (P=7e-7), and ?positive regulation of hemopoiesis? (P=3.15e-6); non-responders showed little transcriptional variation pre-/post-treatment. Unexpectedly, our data included a high load of intronic reads, which may reflect the biology of MDS HSCs, as spliceosome factors are frequently mutated in MDS; thus, differential splice isoform usage will be characterized in our future analyses. As we expand our data set to additional patients, we expect to identify transcriptional changes underlying pathways that mediate therapeutic response and resistance. We have also developed pipelines and packages specifically for computational single cell RNAseq analysis, which we will discuss and make publicly available.
Non-Gaussian quantum discord for Gaussian states
Creators: name: Giorda, Paolo
name: Allegra, Michele
name: Paris, Matteo G. A.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In recent years the paradigm based on entanglement as the unique measure of quantum correlations has been challenged by the rise of new correlation concepts, such as quantum discord, able to reveal quantum correlations that are present in separable states. It is in general difficult to compute quantum discord, because it involves a minimization over all possible local measurements in a bipartition. In the realm of continuous variable (CV) systems, a Gaussian version of quantum discord has been put forward upon restricting to Gaussian measurements. It is natural to ask whether non-Gaussian measurements can lead to a stronger minimization than Gaussian ones. Here we focus on two relevant classes of two-mode Gaussian states: squeezed thermal states (STS) and mixed thermal states (MTS), and allow for a range of experimentally feasible non-Gaussian measurements, comparing the results with the case of Gaussian measurements. We provide evidence that Gaussian measurements are optimal for Gaussian states.
description: 12 pages, 9 figures (3 appendices)
Psychosocial Stress Induces Inflammation, Altered Expression Of Neuron And Glia Transcriptomes And Cns Connectivity, And Disrupted Emotionality In Adult Mice
Creators: name: Pryce, Christopher
Publisher: name: Zenodo
Year: 2015

description: Psychosocial stress is a major short- and long-term risk factor for psychiatric and neurodegenerative disorders. One potential mechanism is that stress induces chronic low-level inflammation which in turn leads to excitotoxic and oxidative-stress changes in the CNS. Animal models are essential to demonstrate and understand such aetio-pathophysiological pathways. Adult mice exposed to chronic social stress developed immune-inflammation responses including increases in: splenic inflammatory monocytes and T helper cells, plasma cytokines and kynurenines, CNS region-specific kynurenines and microglia. RNA sequencing identified down-regulated expression of genes characteristic of specific cell types in amygdala and prefrontal cortex, including: myelination genes in oligodendroyctes, parvalbumin gene in GABA interneurons, monoamine receptor and signalling-pathway genes in medium spiny neurons. Resting state fMRI identified increased connectivity within corticolimbic regions e.g. ACC, insula. Behaviourally, psychosocial stress led to reduced motivation to obtain rewarding stimuli and to control aversive stimuli, increased emotional responding to aversive stimuli, and decreased cognitive flexibility. Antidepressant drugs and anti-inflammatory compounds exhibit behavioural efficacy in the model, and novel targets are under investigation.
Targeting Fak Using Inhibitors Of Protein-Protein Interactions
Creators: name: Rond?, Philippe
Publisher: name: Zenodo
Year: 2015

description: The Focal Adhesion Kinase (FAK) is involved in many aspects of the metastatic process including adhesion, migration, and invasion. Indeed, overexpression, hyperphosphorylation and/or elevated activity of FAK have been described in a variety of human cancers. Thus, the development of FAK antagonists as anti-cancer therapy, led to several small inhibitors of FAK kinase function that are currently undergoing clinical trials. FAK is a ubiquitously expressed non-receptor cytoplasmic tyrosine kinase composed of an N-terminal FERM (band 4.1, ezrin, radixin, moesin homology) domain, a central kinase domain, several proline-rich domains and a C-terminal focal adhesion targeting (FAT) domain. Besides its kinase function, FAK posses also scaffolding functions that are highly relevant in cancer signalling. Indeed, according to the Biological General Repository for Interaction Datasets (BioGRID), FAK is involved in none less than 100 unique interactions. FAK localisation at focal adhesions (FAs) is essential for FAK signalling. Structural studies have revealed that FAK targeting to FAs is mediated via FAK-paxillin interactions. Paxillin bind to the FAT (Focal Adhesion Targeting) domain of FAK via two surface exposed hydrophobic patches located in two opposite faces of the FAT four helix bundle. Based on the structure of the FAT domain, we recently used a mutagenesis approach to alter the targeting domain of FAK. Consequently, we generated a FAK mutant that fails to bind paxillin. This mutated form of FAK alters the phosphorylation states of FAK and FAK downstream substrates such as paxillin and p130Cas and consequently disrupt cell adhesion and migration and impaired cell invasion in Src-transformed cells. This proof-of concept study led us to develop several small inhibitory peptides targeting the scaffolding functions of FAK. We are currently evaluated these peptides in different in-vitro cancer models.
Synthesis, crystal structure and magnetism of beta-Fe1.00(2)Se1.00(3) single crystals
Creators: name: Hu, Rongwei
name: Lei, Hechang
name: Abeykoon, Milinda
name: Bozin, Emil S.
name: Billinge, Simon J. L.
name: Warren, J. B.
name: Siegrist, Theo
name: Petrovic, C.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Understanding iron based superconductors requires high quality impurity free single crystals. So far they have been elusive for beta-FeSe and extraction of intrinsic materials properties has been compromised by several magnetic impurity phases. Herein we report synchrotron - clean beta-FeSe superconducting single crystals grown via LiCl/CsCl flux method. Phase purity yields evidence for a defect induced weak ferromagnetism that coexists with superconductivity below Tc. In contrast to Fe1+yTe - based superconductors, our results reveal that the interstitial Fe(2) site is not occupied and that all contribution to density of states at the Fermi level must come from in-plane Fe(1).
description: 8 pages, 11 figures
Peter Glasner: Narrheit und Ästhetik
Creators: name: Rupp, Michael
Publisher: name: Das Mittelalter. Perspektiven mediävistischer Forschung
Year: 2022

description: Peter Glasner, Narrheit und Ästhetik. Erzählen von intriganten Narren im Mittelalter (Kölner Germanistische Studien 14). Köln, Böhlau Verlag 2021. 347 S. 2 s/w-Abb.
description: Das Mittelalter. Perspektiven mediävistischer Forschung, Bd. 27 Nr. 2 (2022): Die Materialität von Kredit. Sachüberlieferungen mittelalterlicher Schuld- und Kreditbeziehungen
Sediment fluxes dominate glacial-interglacial changes in ocean carbon inventory: results from factorial simulations over the past 780,000 years
Creators: name: Adloff, Markus
name: Jeltsch-Thömmes, Aurich
name: Pöppelmeier, Frerk
name: Stocker, Thomas F.
name: Joos, Fortunat
Publisher: name: University of Bern
publisherIdentifier: https://ror.org/02k7v4d05
publisherIdentifierScheme: ROR
Year: 2024

description: Atmospheric CO2 concentrations changed over ice age cycles due to net exchange fluxes between land, ocean, ocean sediments, atmosphere, and the lithosphere. Marine sediment and ice cores preserved biogeochemical evidence of these carbon transfers, which resulted from sensitivities of the various carbon reservoirs to climate forcing, many of which remain poorly understood. Numerical studies proved the potential of several physical and biogeochemical processes to impact atmospheric CO2 under steady-state glacial conditions. Yet, it is unclear how much they affected carbon cycling during transient changes of repeated glacial cycles, and what role burial and release of sedimentary organic and inorganic carbon and nutrients played. Addressing this uncertainty, we produced a simulation ensemble of various physical and biogeochemical carbon cycle forcings over the repeated glacial inceptions and terminations of the last 780 kyr with the Bern3D Earth system model of intermediate complexity including dynamic marine sediments. This ensemble allows for assessing transient carbon cycle changes due to these different forcings and gaining a process-based understanding of the associated carbon fluxes and isotopic shifts in a continuously perturbed Earth system. We present results of the simulated Earth system dynamics in the non-equilibrium glacial cycles and a comparison with multiple proxy time series. In our simulations the ocean inventory changed by 200–1400 GtC and the atmospheric inventory by 1–150 GtC over the last deglaciation. DIC changes differ by a factor of up to 28 between simulations with and without interactive sediments, while CO2 changes in the atmosphere are at most four times larger when interactive sediments are simulated. Simulations with interactive sediments show no clear correlations between DIC or nutrient concentrations and atmospheric CO2 change, highlighting the likely need for multi-proxy analyses to understand global carbon cycle changes during glacial cycles in practice. Starting transient simulations with an interglacial geologic carbon cycle balance causes isotopic drifts that require several 100 kyr to overcome, and needs to be considered when designing spin-up strategies.
Thomas Ertl: Bauern und Banker
Creators: name: Kehnel, Annette
Publisher: name: Das Mittelalter. Perspektiven mediävistischer Forschung
Year: 2022

description: Thomas Ertl, Bauern und Banker. Wirtschaft im Mittelalter. Darmstadt, Wissenschaftliche Buchgesellschaft 2021. 300 S.
description: Das Mittelalter. Perspektiven mediävistischer Forschung, Bd. 27 Nr. 2 (2022): Die Materialität von Kredit. Sachüberlieferungen mittelalterlicher Schuld- und Kreditbeziehungen
Associations between subclinical thyroid dysfunction and cardiovascular 2 risk factors according to age and sex [supplemental material].
Creators: name: Baretella, Oliver
name: Blum, Manuel
name: Abolhassani, Nazanin
name: Alwan, Heba
name: Åsvold Bjørn Olav
name: Del Giovane, Cinzia
name: Tal, Kali
name: Moutzouri, Elisavet
name: Cappola, Anne R.
name: Gussekloo, Jacobijn
name: Iacoviello, Massimo
name: Iervasi, Giorgio
name: Imaizumi, Misa
name: Weiler, Stefan
name: Razvi, Salman
name: Sgarbi, Jose
name: Wildisen, Lea
name: Völzke, Henry
name: Brown, Suzanne J.
name: Walsh, John
name: Vaes, Bert
name: Yeap, Bu
name: Dullaart, Robin PF
name: Bakker, Stephan JL
name: Kavousi, Maryam
name: Ceresini, Graziano
name: Ferrucci, Luigi
name: Aujesky, Drahomir
name: Peeters, Robin P.
name: Bauer, Douglas C.
name: Feller, Martin
name: Rodondi, Nicolas
Publisher: name: University of Bern
publisherIdentifier: https://ror.org/02k7v4d05
publisherIdentifierScheme: ROR
Year: 2024

description: Baretella and Blum contributed equally to this work (shared first authorship). Feller and Rodondi contributed equally to this work (shared last authorship).
title: Διερεύνηση της δυνατότητας εφαρμογής εργαλείων στατιστικού ελέγχου ποιότητας και διεργασιών στην παραγωγή δευτερογενούς αλουμινίου
Creators: name: Ντουρντουρεκα Αγγελικη
Publisher: name: Technical University of Crete
Year: 2023

description: Σε σύγκριση με άλλα ευρέως χρησιμοποιούμενα μέταλλα όπως ο χαλκός, ο μόλυβδος, το μαγνήσιο και ο χάλυβας, η παραγωγή αλουμινίου έχει μία από τις μεγαλύτερες ενεργειακές διαφορές μεταξύ πρωτογενούς και δευτερογενούς παραγωγής. Με χρήση της σύγχρονης τεχνολογίας, η διαδικασία ανακύκλωσης αλουμινίου απαιτεί πολύ λιγότερη κατανάλωση ενέργειας από την πρωτογενή παραγωγή του. Αυτό βοηθά στην εξοικονόμηση ενέργειας και πρώτων υλών, ενώ παράλληλα μειώνει τις απαιτήσεις για χώρους υγειονομικής ταφής για την τελική διάθεση των απορριμμάτων, καθιστώντας το παράδειγμα κυκλικής οικονομίας.
Ο χαρακτηρισμός (προσδιορισμός της χημικής σύστασης) του scrap αλουμινίου διαδραματίζει κρίσιμο ρόλο στην ανακύκλωσή του. Οι φορητοί αναλυτές φθορισμού ακτίνων Χ (hand-held XRF analyser) αποτελούν σήμερα το πιο διαδεδομένο όργανο για επιτόπιες μετρήσεις σε scrap μετάλλων. Στην εργασία αυτή αξιολογείται η αποτελεσματικότητα ενός φορητού αναλυτή XRF για τον χαρακτηρισμό scrap αλουμινίου χρησιμοποιώντας τεχνικές στατιστικού ελέγχου ποιότητας. Συγκεκριμένα χρησιμοποιείται η μέθοδος crossed Gage R&R για την εκτίμηση της αξιοπιστίας της μετρητικής διάταξης, ενώ τα στοιχεία που μετρήθηκαν ήταν: Si, Fe, Cu, Mn, Mg, Cr, Ni, Zn, Pb και Zr. Χρησιμοποιήθηκε ένας αριθμός δειγμάτων αλουμινίου με γνωστή σύνθεση (πρότυπα) και ελήφθησαν πολλαπλές μετρήσεις σε κάθε δείγμα από διαφορετικούς χειριστές για να αξιολογηθεί η επαναληψιμότητα και η αναπαραγωγιμότητα του οργάνου. Επιπλέον, η ακρίβεια του αναλυτή XRF αξιολογήθηκε συγκρίνοντας τη μετρούμενη τιμή με την τιμή του προτύπου. Τα αποτελέσματα της ανάλυσης ANOVA έδειξαν ότι ο φορητός αναλυτής XRF έχει καλή επαναληψιμότητα και αναπαραγωγιμότητα, για την πλειονότητα των στοιχείων που μετρήθηκαν. Επίσης υπάρχει και ισχυρή συσχέτιση μεταξύ των μετρήσεων και των τιμών αναφοράς, για την πλειονότητα των στοιχείων. Με βάση τα αποτελέσματα αυτά φαίνεται ότι η χρήση φορητών αναλυτών XRF για επιτόπια ανάλυση scrap αλουμινίου, αποτελεί μια καλή επιλογή διευκολύνοντας την ταχεία λήψη αποφάσεων και τον ποιοτικό έλεγχο.
Babett Edelmann-Singer u. Susanne Ehrich (Hgg.): Sprechende Objekte
Creators: name: Kraus, Thomas J.
Publisher: name: Das Mittelalter. Perspektiven mediävistischer Forschung
Year: 2022

description: Babett Edelmann-Singer u. Susanne Ehrich (Hgg.), Sprechende Objekte. Materielle Kultur und Stadt zwischen Antike und Früher Neuzeit (Forum Mittelalter Studien 17). Regensburg, Schnell & Steiner 2021. 287 S. 75 Abb.
description: Das Mittelalter. Perspektiven mediävistischer Forschung, Bd. 27 Nr. 2 (2022): Die Materialität von Kredit. Sachüberlieferungen mittelalterlicher Schuld- und Kreditbeziehungen