cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Correlation between serum complement component 4 levels and tubular atrophy in patients with lupus nephritis
Creators: name: Chang, Zheyi
name: Hu, Haofei
name: Cheng, Yuan
name: Xu, Ricong
name: Wan, Qijun
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy

description: The aim of this study is to examine the relationship between serum complement component 4 (C4) levels and tubular atrophy in patients with lupus nephritis (LN). Patients diagnosed with LN through renal biopsy were retrospectively analyzed and categorized into two groups: the tubular atrophy group (TA group) and the non-tubular atrophy group (non-TA group). Demographic data, clinical characteristics, and pathological findings were compared between the groups. Logistic regression and spline smoothing plot analysis, utilizing the generalized additive mixed model, were employed to investigate the relationship between serum C4 levels and the occurrence of tubular atrophy. A total of 129 patients were included in the study, with 57 (44.2%) identified as having tubular atrophy (TA group), while the remaining 72 patients did not present with tubular atrophy (non-TA group). Patients in the TA group exhibited higher serum C4 levels (p = 0.008) and lower eGFR (p = 0.001) compared to those in the non-TA group. Pathological findings revealed that the TA group had a higher incidence of mesangial hypercellularity (p = 0.041), endocapillary hypercellularity (85.96% vs. 68.06%, p = 0.018), interstitial inflammation (p < 0.018), karyorrhexis (78.95% vs. 59.72%, p = 0.02), and arteriole hypertrophy (66.67% vs. 38.89%, p = 0.02). Multivariate logistic regression analysis revealed that elevated serum C4 levels were associated with tubular atrophy in patients with LN (OR = 1.069, 95% CI 1.001 − 1.141, p = 0.048). Furthermore, spline smoothing analysis using the generalized additive mixed model indicated a linear relationship between serum C4 levels and the occurrence of tubular atrophy events. This linear relationship remained consistent across various stratifications, including age, hypertension, leukocyte count, hemoglobin levels, and estimated glomerular filtration rate (eGFR). Serum C4 levels demonstrate a significant correlation with the presence of tubular atrophy in patients diagnosed with LN.
Additional file 1 of Risk indicators for oral ulcers among people living with HIV during the first wave of the pandemic: a cross sectional study
Creators: name: Folayan, Morenike Oluwatoyin
name: Zuñiga, Roberto Ariel Abeldaño
name: Virtanen, Jorma I.
name: Aly, Nourhan M.
name: Ezechi, Oliver C
name: Lusher, Joanne
name: El Tantawi, Maha
name: Nguyen, Annie L
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Supplementary Material 1
Replicator dynamics on heterogeneous networks
Creators: name: Li, Junjie
name: Wang, Xiaomin
name: Li, Cong
name: Zhang, Boyu
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 490102
subject: Biological mathematics

description: Networked evolutionary game theory is a well-established framework for modelling the evolution of social behavior in structured populations. Most of existing studies in this field focused on 2-strategy games on heterogenous networks or n-strategy games on regular networks. In this paper, we consider n-strategy games on arbitrary networks under the pairwise comparison updating rule. We show that in the limit of weak selection, the short-run behavior of the stochastic evolutionary process can be approximated by replicator equations with a transformed payoff matrix that involves both the average value and the variance of the degree distribution. In particular, strongly heterogeneous networks can facilitate the evolution of the payoff dominant strategy. We then apply our results to analyze the evolutionarily stable strategies in an n-strategy minimum-effort game and two variants of the Prisoner's Dilemma game. We show that the cooperative equilibrium becomes evolutionarily stable when the average degree of the network is low and the variance of the degree distribution is high. Agent-based simulations on quasi-regular, exponential, and scale-free networks confirm that the dynamic behaviors of the stochastic evolutionary process could be well approximated by the trajectories of the replicator equations.
Mello, Heitor de
Creators: name: Ficher, Sylvia
name: P. Palazzo, Pedro
Publisher: name: Oxford University Press
Year: 2019
Subjects: subject: Brazil--Rio de Janeiro
subject: Architecture
subject: FOS: Civil engineering
subject: History

description: Brazilian architect. He was an influential eclectic architect highly active in Rio de Janeiro and a professor at the Escola Nacional de Belas Artes (ENBA). Soon after graduating from the ENBA, he established his firm in 1898. The son of Custódio José de Mello, a republican admiral and cabinet minister, Mello benefited from his family's connections to garner major commissions early in his career. Thanks to the large-scale building campaigns then occurring in Rio—as the enlargement of the harbor and the opening of Avenida Central (now Avenida Rio Branco)—his office became one of the earliest large planning and construction firms in the Federal Capital.
Mello, Heitor de
Creators: name: Ficher, Sylvia
name: P. Palazzo, Pedro
Publisher: name: Humanities Commons
Year: 2019
Subjects: subject: Architecture
subject: FOS: Civil engineering
subject: History
subject: Brazil--Rio de Janeiro

description: Brazilian architect. He was an influential eclectic architect highly active in Rio de Janeiro and a professor at the Escola Nacional de Belas Artes (ENBA). Soon after graduating from the ENBA, he established his firm in 1898. The son of Custódio José de Mello, a republican admiral and cabinet minister, Mello benefited from his family’s connections to garner major commissions early in his career. Thanks to the large-scale building campaigns then occurring in Rio—as the enlargement of the harbor and the opening of Avenida Central (now Avenida Rio Branco)—his office became one of the earliest large planning and construction firms in the Federal Capital.
I Like What I See: Exploring the Role of Media Format on Benefits of Allyship Among Black Women
Creators: name: Rhodes, Virginia L
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Industrial and organisational psychology (incl. human factors)

description: Science, technology, engineering, and math (STEM) researchers and organizations recognize that a large gender and racial disparity exists in these fields. However, individuals with intersectional identities (i.e., Black women) have unique experiences of bias that preclude them from entering STEM careers and feeling a sense of belonging. As such, featuring an employee that demonstrates allyship for Black women on an organization’s website can be a useful identity-safe cue to signal that a Black woman’s identity will be valued and promote the recruitment of Black women in STEM organizations. Yet, research indicates that Black women who are high in stigma consciousness (i.e., sensitive to potential discrimination based on their identity) do not trust or believe a White woman ally presented in a written profile cares about helping Black women. The current study found that presenting an ally in a video profile mitigated these negative effects of stigma consciousness, and increased Black women’s anticipated belonging and trust in a fictional STEM organization via higher perceptions of allyship. Theoretical implications for research, practical implications for organizations, and future research avenues to explore are discussed.
ENGINEERING FLUORESCENT PROTEIN BIOSENSORS FOR INTERROGATING BIOLOGICALLY RELEVANT CHEMICAL SPECIES
Creators: name: Trull, Keelan J
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Biochemistry and cell biology not elsewhere classified

description: Fluorescent proteins and the biosensors created with them have been used extensively to monitor chemical species inside and outside of the cell. They have been used to increase our knowledge of cellular function in normal and diseased states. Fluorescent biosensors are advantageous because they can be genetically encoded, do not require exogenous reagents, and can be quantitative. Fluorescent biosensors are also able to measure analytes with high spatial and temporal resolutions, enabling measurements at the scale of physiological events. In this thesis efforts have made to increase the available fluorescent biosensor tools for imaging cellular events. This work includes creation of new sensors for two molecules not yet detectable via fluorescent protein biosensor, acetylcholine and adenosine diphosphate. Efforts were also made to improve the current available biosensors for adenosine triphosphate and cellular redox, to make them more compatible with multiplex and deep tissue imaging. Here I present my work to design, characterize and utilize these fluorescent biosensors.
sj-pdf-2-jef-10.1177_15589250211032324 – Supplemental material for Flexural behavior analysis of composites with triaxial woven fabric as reinforcement
Creators: name: Rao, Yunfei
name: Zhang, Chen
name: Li, Zhe
name: Li, Qianqian
name: Zhang, Honghua
name: Li, Wei
Publisher: name: SAGE Journals
Year: 2021
Subjects: Materials Engineering not elsewhere classified

description: Supplemental material, sj-pdf-2-jef-10.1177_15589250211032324 for Flexural behavior analysis of composites with triaxial woven fabric as reinforcement by Yunfei Rao, Chen Zhang, Zhe Li, Qianqian Li, Honghua Zhang and Wei Li in Journal of Engineered Fibers and Fabrics
Additional file 1 of A rapid review to inform the policy and practice for the implementation of chronic disease prevention and management programs for Aboriginal and Torres Strait Islander people in primary care
Creators: name: Yadav, Uday Narayan
name: Davis, Jasmine Meredith
name: Bennett-Brook, Keziah
name: Coombes, Julieann
name: Wyber, Rosemary
name: Pearson, Odette
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Study characteristics.
Mediated roles of oxidative stress and kidney function to leukocyte telomere length and prognosis in chronic kidney disease
Creators: name: Yi, Jiahong
name: Jiang, Chang
name: Xia, Liangping
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Medicine
Cell Biology
Molecular Biology
Biological Sciences not elsewhere classified
Marine Biology
Cancer
Science Policy

description: Few studies have focused on the correlation between leukocyte telomere length (LTL) and cancer-related mortality or identified potential factors that mediate the relationship between LTL and mortality among chronic kidney disease (CKD) patients. Our study aimed to explore the associations between LTL and all-cause and cause-specific mortality and to identify the underlying mediators. CKD patients were obtained from the National Health and Nutrition Examination Survey (NHANES) 1999–2002. Cox regression analysis and restricted cubic spline analysis were used to explore the associations between LTL and all-cause or specific-cause mortality and their nonlinear connections. Stratified analyses were executed to assess the relationships among the different subgroups. The latent mediated factors were confirmed using mediation analysis. Sensitivity analyses were used to evaluate the robustness of our findings. Longer LTL associated with the lower risk of all-cause mortality, cardiovascular disease (CVD) and cancer-related mortality, and U-shaped relationships were detected. Patients younger than 65 years with greater LTL or who had hypertension had better prognoses. Age and history of hypertension were associated with LTL and overall mortality. In addition, estimated glomerular filtration rate (eGFR), albumin, and total bilirubin mediated the association, and the proportions of indirect effects were 7.81%, 3.77%, and 2.50%, respectively. Six sensitivity analyses confirmed the robustness of our findings. This study revealed that LTL was a protective factor for survival among patients with CKD and emphasized the mediating roles of oxidative stress and kidney function.
sj-pdf-3-tam-10.1177_17588359211018018 – Supplemental material for Is there any room for PD-1 inhibitors in combination with platinum-based chemotherapy as frontline treatment of extensive-stage small cell lung cancer? A systematic review and meta-analysis with indirect comparisons among subgroups and landmark survival analyses
Creators: name: Gristina, Valerio
name: Galvano, Antonio
name: Castellana, Luisa
name: Insalaco, Lavinia
name: Cusenza, Stefania
name: Graceffa, Giuseppa
name: Iacono, Federica
name: Barraco, Nadia
name: Castiglia, Marta
name: Perez, Alessandro
name: Rizzo, Sergio
name: Russo, Antonio
name: Bazan, Viviana
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 110203 Respiratory Diseases

description: Supplemental material, sj-pdf-3-tam-10.1177_17588359211018018 for Is there any room for PD-1 inhibitors in combination with platinum-based chemotherapy as frontline treatment of extensive-stage small cell lung cancer? A systematic review and meta-analysis with indirect comparisons among subgroups and landmark survival analyses by Valerio Gristina, Antonio Galvano, Luisa Castellana, Lavinia Insalaco, Stefania Cusenza, Giuseppa Graceffa, Federica Iacono, Nadia Barraco, Marta Castiglia, Alessandro Perez, Sergio Rizzo, Antonio Russo and Viviana Bazan in Therapeutic Advances in Medical Oncology
sj-docx-1-jhi-10.1177_14604582211033014 – Supplemental material for Real-world data-based adverse drug reactions detection from the Korea Adverse Event Reporting System databases with electronic health records-based detection algorithm
Creators: name: Shin, Hyunah
name: Cha, Jaehun
name: Lee, Youngho
name: Kim, Jong-Yeup
name: Lee, Suehyun
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 89999 Information and Computing Sciences not elsewhere classified
subject: FOS: Computer and information sciences

description: Supplemental material, sj-docx-1-jhi-10.1177_14604582211033014 for Real-world data-based adverse drug reactions detection from the Korea Adverse Event Reporting System databases with electronic health records-based detection algorithm by Hyunah Shin, Jaehun Cha, Youngho Lee, Jong-Yeup Kim and Suehyun Lee in Health Informatics Journal
Gender Bias in Teaching Evaluations
Creators: name: Kim, Kaylyn
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Community psychology
Social psychology

description: End-of-the-semester teaching evaluations hold consequential weight in professors’ career outcomes, which can be problematic if these evaluations are affected by gender bias. This research sought to examine gender bias in evaluations of professors through two experimental studies (via a 15-minute online lecture and a university-sanctioned online course), offering two ecologically valid manipulations of professor gender. Student gender and field of study were examined as moderators of this gender bias, as effects may be more pronounced among male raters compared to female raters, or among raters in majors that underrepresent women compared to raters in other majors. Findings revealed an effect of professor’s gender in the opposite direction: On average, students rated female professors more positively than they did male professors. Student gender and field of study did not affect professor ratings, nor did they moderate the effect of professor gender.
Structural and Mechanistic Insights into Regulation of RGS17 and PLCepsilon
Creators: name: Sieng, Monita
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Biochemistry and cell biology not elsewhere classified

description: Recent advances in structural biology and biochemistry have identified proteins downstream of G protein-coupled receptors (GPCRs) as promising drug targets. These proteins are highly regulated to ensure proper physiological responses from extracellular stimuli. Dysregulation of these signaling enzymes can have detrimental consequences, including cardiovascular disease and cancer. Understanding how these proteins are regulated from a structural and biochemical standpoint can therefore be exploited to develop new therapeutics. In this work, the molecular mechanism of regulation of two different proteins downstream of GPCRs is investigated. The first protein, Regulator of G Protein Signaling 17 (RGS17), is involved in numerous processes throughout the body, including the development and progression of lung cancer. This work presents the crystal structure of RGS17 bound to Ca2+. Ca2+ was found to bind to the same site as the predicted Ga binding surface and increases interactions between RGS17 and Gao. Therefore, Ca2+ positively regulates RGS17, supporting a mechanism in which Ca2+ increases the GTPase activating function of the RZ-family of RGS proteins to ultimately downregulate Ca2+ signaling. The second protein, phospholipase Ce (PLCe), has been implicated in cardiac hypertrophy through its production of second messengers. This process is regulated by the small GTPase Rap1A. This work presents insight into the molecular mechanism of Rap1A-dependent activation of PLCe, in which four conserved, hydrophobic residues on the surface of the RA2 domain of PLCe play an essential role. Furthermore, small angle X-ray scattering studies show that binding of Rap1A induces conformational changes in PLCe, resulting in a more compact activated complex. This supports a mechanism in which Rap1A is an allosteric activator of PLCe, inducing conformational changes in PLCe that increase lipid hydrolysis by relieving autoinhibitory interactions and/or by promoting interactions with the cell membrane.
Additional file 2 of A rapid review to inform the policy and practice for the implementation of chronic disease prevention and management programs for Aboriginal and Torres Strait Islander people in primary care
Creators: name: Yadav, Uday Narayan
name: Davis, Jasmine Meredith
name: Bennett-Brook, Keziah
name: Coombes, Julieann
name: Wyber, Rosemary
name: Pearson, Odette
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2. Meta aggregated study findings.
Fragmento e todo: duas imagens urbanas entre oriente e ocidente, c. 1600
Creators: name: P. Palazzo, Pedro
Publisher: name: Humanities Commons
Year: 2018
Subjects: subject: Art, Japanese
subject: Printing--Social aspects
subject: World history

description: This article analyzes representations of cities in two pictures created around 1600: Theodor de Bry’s engraving of Macao, and the views of Kyoto attributed to Iwasa Katsumochi Matabei. The relationship between fragmented and total forms of repre- sentation is studied in both pictures. The European engraving depicts urban space as a whole, while the Japanese painting portrays a number of fragmentary scenes separated by golden clouds. However, the global picture in the European print is fragmented by the multiplication of simultaneous perspectives, while the Japanese screen displays underlying global order due to its cavalier projection. In both cases there is interaction between fragmentary views and a global outlook that relate in diverse ways.
sj-pdf-6-jva-10.1177_11297298211031339 – Supplemental material for Trendelenburg position for internal jugular vein catheterization: A systematic review and meta-analysis
Creators: name: Garcia-Leal, Mariana
name: Guzman-Lopez, Santos
name: Verdines-Perez, Adrian Manuel
name: de Leon-Gutierrez, Humberto
name: Fernandez-Rodarte, Bernardo Alfonso
name: Alvarez-Villalobos, Neri Alejandro
name: Martinez-Garza, Javier Humberto
name: Quiroga-Garza, Alejandro
name: Elizondo-Omaña, Rodrigo Enrique
Publisher: name: SAGE Journals
Year: 2021
Subjects: Cardiology

description: Supplemental material, sj-pdf-6-jva-10.1177_11297298211031339 for Trendelenburg position for internal jugular vein catheterization: A systematic review and meta-analysis by Mariana Garcia-Leal, Santos Guzman-Lopez, Adrian Manuel Verdines-Perez, Humberto de Leon-Gutierrez, Bernardo Alfonso Fernandez-Rodarte, Neri Alejandro Alvarez-Villalobos, Javier Humberto Martinez-Garza, Alejandro Quiroga-Garza and Rodrigo Enrique Elizondo-Omaña in The Journal of Vascular Access
sj-pdf-3-han-10.1177_15589447211028925 – Supplemental material for Versatility of the Posterior Interosseous Artery Flap: Emphasis on Powering Up the Toe Transfer
Creators: name: Lee, GiJun
name: Kim, BumSik
name: Jeon, Neunghan
name: Yoon, JungSoo
name: Hong, Ki Yong
name: Lim, SooA
name: Eo, SuRak
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Medicine
subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-3-han-10.1177_15589447211028925 for Versatility of the Posterior Interosseous Artery Flap: Emphasis on Powering Up the Toe Transfer by GiJun Lee, BumSik Kim, Neunghan Jeon, JungSoo Yoon, Ki Yong Hong, SooA Lim and SuRak Eo in HAND
sj-pdf-4-han-10.1177_15589447211028925 – Supplemental material for Versatility of the Posterior Interosseous Artery Flap: Emphasis on Powering Up the Toe Transfer
Creators: name: Lee, GiJun
name: Kim, BumSik
name: Jeon, Neunghan
name: Yoon, JungSoo
name: Hong, Ki Yong
name: Lim, SooA
name: Eo, SuRak
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Medicine
subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-4-han-10.1177_15589447211028925 for Versatility of the Posterior Interosseous Artery Flap: Emphasis on Powering Up the Toe Transfer by GiJun Lee, BumSik Kim, Neunghan Jeon, JungSoo Yoon, Ki Yong Hong, SooA Lim and SuRak Eo in HAND
STRUCTURE-FUNCTION OF MEMBRANE PROTEIN COMPLEXES INVOLVED IN OXYGENIC PHOTOSYNTHESIS
Creators: name: Bhaduri, Satarupa
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Animal physiology - biophysics
Human biophysics
Structural biology (incl. macromolecular modelling)

description: Three aspects of the electron transport chain have been investigated in the present studies: (i) structure-function studies of the central proton-electron conducting cytochrome b6fcomplex, focusing on the effect of lipids in structural stabilization and electron transfer function; (ii) transmembrane electron transfer pathways in the cytochrome b6fand mitochondrial cytochrome bc1complexes, determined by heterogeneity in the internal polarity of the membrane protein complexes; and (iii) purification and characterization of a novel ~1 MDa supercomplex, dominated by the presence of photosystem I (PSI), ATP-synthase and ferredoxin-NADP+reductase (FNR) from higher plant system Spinacea.
Wireless body area network: Development of a physiological sensor suite
Creators: name: Jaiswal, Amit
Publisher: name: Zenodo
Year: 2012
Subjects: Wireless sensor network
Physiological signals
Wireless health monitoring
Arduino

description: The aim of this study was to develop a light, wearable physiological sensor suite integrated with many electronic biosensors on a single acquisition board to take most of the biosignals and then transmit these signals wirelessly to the base station located many kilometers away from them for the study and monitoring of the physiological status of army 'jawans in real time.In this task, the lightweight, small-size, low-cost, low-power, open-source, and multichannel acquisition board Arduino Mega 2560 rev3 is used as the node platform. All the sensors are as lightweight as possible and handmade to reduce the cost and system weight.Here, temperature, heart rate/pulse rate, galvanic skin response, and electromyogram sensing are done up to real hardware implementation, and ECG & EEG sensing is done only up to virtual hardware due to much noisy response, and the concept for this sensing is studied completely.The wireless transmission of bio-signals (temperature, HR, GSR, EMG) to a PC is done for a short range of 2 meters via Bluetooth. The wireless sensor networking part is done conceptually but unable to be implemented on real hardware due to single node availability.These results signify that it is possible to implement all the sensors in a single suite, but noise is the main problem for acquiring the actual response, mainly in ECG and EEG. So now we are able to develop it further for EEG and ECG, also with better noise removal logic and a long range.
The role of the estimated glomerular filtration rate and body roundness index in the risk assessment of uric acid-lowering therapy-resistant gout in U.S. adults: evidence from the National Health and Nutrition Examination Survey (2007–2018)
Creators: name: Zhu, Mengyuan
name: Wang, Xingqiang
name: Peng, Zining
name: Yan, Weitian
name: Deng, Qian
name: Li, Meihui
name: Liu, Nian
name: Zhang, Ling
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Marine Biology
subject: Science Policy

description: To explore the risk factors for uric acid-lowering therapy-resistant gout (UALT-RG) and its relationships with the estimated glomerular filtration rate (eGFR), body roundness index (BRI), and visceral adiposity index (VAI) via 2007–2018 National Health and Nutrition Examination Survey (NHANES) data. We calculated the BRI using waist circumference and standing height; the VAI using triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C), and body mass index (BMI); and the eGFR from serum creatinine levels. We also collected gout data. We explored the relationships of the eGFR, BRI, and VAI with UALT-RG risk via univariable and multivariable weighted logistic regression, trend analysis, and restricted cubic splines. Among the 1,811 patients with gout, ∼9.08% had UALT-RG; these patients were more likely to have obesity, comorbid diabetes (36% [27–47%] vs. 25% [22–28%]) or impaired kidney function (eGFR < 60 mL/min/1.73 m2, 34.5% [27–43%] vs. 22.5% [20–26%]); be former smokers; and take colchicine (10% [5.6–19%] vs. 4.3% [2.8–6.7%]). Logistic regression and trend analysis suggested that an elevated BRI and decreased eGFR were independent risk factors and potential screening indicators for UALT-RG. Restricted cubic spline analysis revealed a negative linear trend between the eGFR and UALT-RG risk (p-overall < 0.0001) and a significant positive correlation between the BRI and UALT-RG risk (p-overall < 0.0001). An increased BRI and decreased eGFR may be independent risk factors and assessment indicators for UALT-RG in U.S. adults. It is necessary to monitor serum urate levels more closely and conduct early multidisciplinary comanagement when gout is comorbid with visceral obesity and chronic kidney disease stages 3–5.
Insights into the Role of the Membrane on Phospholipase C Beta and G Alpha Q-Mediated Activation
Creators: name: Hudson, Brianna N
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Biochemistry and cell biology not elsewhere classified

description: Phospholipase Cβ (PLCβ) cleaves phosphatidylinositol-4,5-bisphosphate (PIP2) into the second messengers inositol-1,4,5-triphosphate (IP3) and diacylglycerol (DAG). IP3 increases intracellular Ca2+, while DAG remains in the membrane, and together with increased Ca2+, activates protein kinase C (PKC). PLCβ has low basal activity but is activated following stimulation of Gi- and Gq-coupled receptors through direct interactions with Gαq and Gβγ. PLCβ is essential for normal cardiomyocyte and vascular smooth muscle function and regulates cell proliferation, survival, migration, and differentiation. However, increased PLCβ activity and expression results in arrhythmias, hypertrophy, and heart failure. PLCβ must interact with the cell membrane for its activity. While heterotrimeric G proteins stimulate PLCβ, they are insufficient for full activation, suggesting the membrane itself contributes to increased lipid hydrolysis, potentially via interfacial activation. However, how the composition of the membrane and its resulting properties, such as surface charge, contribute to adsorption and interfacial activation is not well-established. Furthermore, whether or how interfacial activation also impacts other regulatory elements in PLCβ and Gαq-dependent activation is unknown. Using an innovative combination of atomic force microscopy on compressed lipid monolayers and biochemical assays, we are beginning to understand how the membrane itself, PLCβ autoinhibitory elements and Gαq regulate PLCβ activation. These studies provide the first structure-based approach to understanding how the cell membrane regulates the activity of this essential effector enzyme.
Right ventricular-pulmonary arterial coupling and pulmonary hypertension in hemodialysis: insights into structural cardiac changes and clinical implications
Creators: name: Salajova, Kristina Buryskova
name: Malik, Jan
name: Kaiserova, Lucie
name: Hladinova, Zuzana
name: Hruskova, Zdenka
name: Janakova, Simona
name: Tesar, Vladimir
name: Pesickova, Satu Sinikka
name: Michalickova, Kristyna
name: Rocinova, Katarina
name: Szonowska, Barbora
name: Valerianova, Anna
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer
subject: Science Policy
subject: Mental Health

description: This cross-sectional analysis from the CZecking Heart Failure in patients with advanced Chronic Kidney Disease trial (ISRCTN18275480) examined pulmonary hypertension and right ventricular-pulmonary arterial coupling in patients on chronic hemodialysis. The aims of this analysis were: 1. To analyze relations between pulmonary hypertension and right ventricular-pulmonary arterial coupling with dialysis access flow and current hydration; 2. To analyze structural heart changes associated with right ventricular-pulmonary arterial uncoupling; 3. To reveal the prevalence, etiology and severity of pulmonary hypertension in the Czech hemodialysis population. We performed expert echocardiography, vascular access flow measurements, bioimpedance analysis, and laboratory testing in 336 hemodialysis patients. Pulmonary hypertension was present in 34% (114/336) patients and right ventricular-pulmonary arterial uncoupling was present in 25% of patients with pulmonary hypertension. Only weak associations between the flow of the dialysis arteriovenous access and estimated pulmonary arterial systolic pressure and right ventricular-pulmonary arterial coupling was proved. There was a strong association between hydration status assessed by estimated central venous pressure with pulmonary arterial systolic pressure (Rho 0.6, p < 0.0001) and right ventricular-pulmonary arterial coupling (Rho −0.52, p < 0.0001) and association between overhydration to extracellular water ratio with pulmonary arterial systolic pressure (Rho 0.31, p = 0.0001) and right ventricular-pulmonary arterial coupling (Rho −0.29, p = 0.002). The prevalence of heart failure was significantly higher in patients with right ventricular-pulmonary arterial uncoupling (88% vs. 52%, p = 0.0003). These findings suggest that optimizing volume status and treating heart failure should be prioritized in hemodialysis patients to prevent pulmonary hypertension progression and right ventricular-pulmonary arterial uncoupling.
sj-docx-1-smo-10.1177_20503121211034384 – Supplemental material for Knowledge, attitude, and utilization of drugs toward COVID-19 pandemic among Bale Zone residents, Southeast Ethiopia
Creators: name: Mamo, Ayele
name: Hassen, Mesud M
name: Adem, Ahmednur
name: Teferu, Zinash
name: Kumbi, Musa
name: Husen, Abduljewad
name: Solomon, Damtew
name: Lette, Abate
name: Hailu, Sintayew
name: Sinba, Edao
name: Abduletif, Abdushakur M
name: Kassim, Jeylan
name: Walle, Gashaw
name: Atlaw, Daniel
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: Cardiology
subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine
subject: 110305 Emergency Medicine
subject: 110306 Endocrinology
subject: 110308 Geriatrics and Gerontology
subject: 110904 Neurology and Neuromuscular Diseases
subject: 111099 Nursing not elsewhere classified
subject: 111199 Nutrition and Dietetics not elsewhere classified
subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: 110314 Orthopaedics
subject: 110604 Sports Medicine
subject: 110315 Otorhinolaryngology
subject: 111702 Aged Health Care
subject: 111403 Paediatrics
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 110203 Respiratory Diseases
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology
subject: 110323 Surgery
subject: 70706 Veterinary Medicine
subject: FOS: Veterinary sciences

description: Supplemental material, sj-docx-1-smo-10.1177_20503121211034384 for Knowledge, attitude, and utilization of drugs toward COVID-19 pandemic among Bale Zone residents, Southeast Ethiopia by Ayele Mamo, Mesud M Hassen, Ahmednur Adem, Zinash Teferu, Musa Kumbi, Abduljewad Husen, Damtew Solomon, Abate Lette, Sintayew Hailu, Edao Sinba, Abdushakur M Abduletif, Jeylan Kassim, Gashaw Walle and Daniel Atlaw in SAGE Open Medicine
sj-docx-1-cnr-10.1177_10547738211030640 – Supplemental material for Comparative Analysis of Health Domains for Neuropathic Pain Patients
Creators: name: Bader, Christine
name: Flynn, Diane
name: Buckenmaier, Chester
name: McDonald, Catherine
name: Meghani, Salimah
name: Calilung, Christian
name: Polomano, Rosemary
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, sj-docx-1-cnr-10.1177_10547738211030640 for Comparative Analysis of Health Domains for Neuropathic Pain Patients by Christine Bader, Diane Flynn, Chester Buckenmaier, Catherine McDonald, Salimah Meghani, Christian Calilung and Rosemary Polomano in Clinical Nursing Research
title: ICOS Ecosystem Instructions for Plant Species Reporting
Creators: name: Pellis, Guido
name: Papale, Dario
Publisher: name: ICOS Ecosystem Thematic Centre
Year: 2017
Subjects: ecosystem protocols
plant spacies

description: This Instruction document describes the procedure to report plant species present in the ICOS stations to the ETC. The species classification (to be done in the field or in the lab) is not discussed here because it is a standard procedure that must be done by experts in the station team. The reference nomenclature has to follow the approach of The Plant List database (http://www.theplantlist.org), where multiple taxonomic data sources were merged taking into consideration internationally accepted names and synonymy relationships, and adding additional names and synonymy relationships from regional and national floristic datasets. Further details on the database are available on the original website. The Plant List is a work in progress and, therefore, it may undergo updates; for this reason the website is the reference to be used.
title: ICOS Ecosystem Instructions for Foliar Samples Collection and LMA Ratio Determination
Creators: name: Loustau, Denis
name: Aluome, Christelle
name: Papale, Dario
Publisher: name: ICOS Ecosystem Thematic Centre
Year: 2017
Subjects: ecosystem protocols
LMA ratio
foliar and vegetation sampling

description: The nutritional status of the canopy foliage in terms of macronutrients (C, N, P, K, Ca, Mg, Fe, Cu,
Mn, Zn) has a strong influence on the carbon cycle and energy balance of terrestrial ecosystems and
therefore on the energy, water and greenhouse gas fluxes between terrestrial ecosystems and the
atmosphere. The leaf mass to area ratio, LMA, is also a widely used leaf functional trait the spatial
and temporal variations of which are essential for interpreting canopy exchanges of energy, and
CO2. Foliage macronutrient contents and LMA will be assessed at ICOS Ecosystem stations from
nutrient analyses and mass/area measurements on periodically collected foliar samples. This
document describes how the foliar samples must be selected and taken up and how LMA must be
measured at ICOS Ecosystem stations. It also describes how to prepare and ship samples to ETC’s
analytical lab, where the nutrient analyses are carried out.
The document is structured in different sections with the aim to facilitate the use and application:
- Sampling collection and measurements: the general strategy used for the sampling is shortly
described. The tools and method used to take the leaves or needles composing the samples
together with the collection of metadata requested are presented in order to practically
complete the foliage sampling and LMA determination.
- Maintenance: in this section the possible maintenance activities are reported.
- Submission: it is the section related to the data preparation and submission to the ETC,
including the foliar samples. It includes the list of parameters and the way to submit them
to the database. It is linked to the BADM system.
- Processing: this section describes first how leaf nutrient will be determined by the ETC
laboratory and second how the LMA will be calculated.
It is important to remind that the exact application of the protocol at station level must be also
discussed with ETC in order to reach agreed solutions for specific cases. If a specific part is relevant
only for a specific ecosystem or site Class this is also reported in the document.
Relações de escala na superquadra de Brasília: paradigma ou mistificação?
Creators: name: Gabriel Ernesto Moura, Solórzano
name: P. Palazzo, Pedro
Publisher: name: Humanities Commons
Year: 2020
Subjects: subject: Modernism (Literature)
subject: Latin America
subject: Brazil

description: The superblocks that characterize Brasilia’s urban fabric are defined by Lucio Costa, a posteriori, as the “residential scale” of the city: a play on words that obscures a proper understanding of how the housing mass of the Brazilian capital is structured. In order to perceive more clearly the relations of scale — in its conventional, that is, geometric, sense — in the superblock, we begin by addressing the contradictions inherent in the spatial and discursive abstraction of modernism. From there, we analyze the scale relationships in Brasilia’s residential area according to three successive scopes: the scale articulations around its neighborhood unit, the elements of spatial composition in the superblock, and the role buildings play in actualizing the scales and spatial relations peculiar to this city’s urbanism. At each step, we note how the interpretive categories put forward by several scholars of Brasilia and of modern architecture come together, in their clarifications as well as contradictions, with the abstraction and spatial ambiguity of the superblock. The complex, thus made indivisible, of spaces and discourses upholds the paradigm of modern dwelling, yet this comes at the price of erecting a system of conceptual deceptions.
Additional file 1 of Elective nodal irradiation versus involved-field irradiation for stage II–IV cervical esophageal squamous cell carcinoma patients undergoing definitive concurrent chemoradiotherapy: a retrospective propensity study with 8-year survival outcomes
Creators: name: Wang, Jianing
name: Wu, Yajing
name: Zhang, Wei
name: Chen, Yujia
name: Liu, Qing
name: Jing, Shaowu
name: Zhang, Jiandong
name: Wu, Fengpeng
name: Wang, Jun
name: Qiao, Xueying
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: Additional file 1: Fig. A.1. Overall survival for patients with different clinical T stage (cT) in ENI versus IFI group after propensity score-matched analysis. Fig. A.2. Overall survival for patients with different clinical N stage (cN) in ENI versus IFI group after propensity score-matched analysis. Fig. A.3. Overall survival for patients with clinical TNM stage (cTNM) in ENI versus IFI group after propensity score-matched analysis. Fig. A.4. Overall survival for patients receiving different radiation doses in ENI versus IFI group after propensity score-matched analysis. Fig. A.5. Overall survival for patients with hypopharyngeal invasion or not in ENI versus IFI group after propensity score-matched analysis. Table A.1. Acute toxicity of patients with CESCC receiving dCCRT.
The Impact of the Verb Tense of Tone Words on Price Discovery in Conference Calls
Creators: name: Angelo, Benjamin W
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Accounting, auditing and accountability not elsewhere classified

description: Prior empirical research has shown that forward-looking statements can be particularly informative to investors (Li 2010; Muslu et al. 2014). However, the inherent uncertainty surrounding forward-looking statements may contribute to a delayed price reaction. This paper examines the market reaction to backward-looking statements and to forward-looking statements across a 60 trading-day horizon. I did not find evidence suggesting the inherent uncertainty of forward-looking statements contributes to a delayed price reaction. However, backward-looking statements are associated with a delayed price response. This result is consistent with Bernard and Thomas’s (1990) suggestion that post-earnings announcement drift is caused by investors not fully understanding how current earnings map into future earnings. I also provide evidence that, for the prepared remarks, investors have a stronger price reaction to net backward-looking tone than to net forward-looking tone. However, for the question-and-answer session, the opposite is true. Investors have a stronger price reaction to net forward-looking tone than to net backward-looking tone. This result suggests that managers should focus their prepared remarks on the prior performance of the firm and focus their responses during the question-and-answer session on the future performance of the firm.
The atherogenic index of plasma increases the risk of incident kidney stones: a nested case–control study in Chinese adults
Creators: name: Wang, Dawei
name: Shi, Feng
name: Zhang, Dingguo
name: Wang, Hui
name: Zhu, Yu
name: Wang, Jun
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: To investigate the association between atherogenic index of plasma (AIP) and risk of incident kidney stones. A nested case-control study was conducted using data from the Shanghai Kidney Stone Cohort from December 2018 to February 2023. Kidney stones were ascertained by ultrasound. Propensity score matching selected 2,550 patients with incident kidney stones and 5,100 controls from a total of 64,121 adults. Baseline fasting plasma samples were collected to measure the AIP, defined as the logarithm of the ratio triglycerides to high-density lipoprotein cholesterol. A multivariable conditional logistic regression model and restricted cubic spline were applied to examine the association between the AIP and the risk of incident kidney stones. The baseline AIP values of the incident kidney stone patients and controls were 0.98 (0.67) and 0.91 (0.65), respectively. Patients with incident kidney stones had much higher baseline AIP levels than controls (p < 0.001). Participants in the highest AIP quartile had a 29% greater risk of developing kidney stones. Moreover, each increase in the standard deviation of the AIP was associated with a 10% greater risk of nephrolithiasis. A restricted cubic spline showed a significant positive and linear correlation between the AIP and the risk of developing kidney stones (P-overall = 0.040, P-nonlinear = 0.923). These findings remained robust in sensitivity analyses. A higher AIP is associated with a greater risk of incident kidney stones. A higher atherogenic index of plasma (AIP) significantly increases the risk of kidney stones.Each standard deviation increase in AIP is associated with a 10% higher risk of nephrolithiasis.The study suggests incorporating AIP assessment into management strategies for kidney stone prevention. A higher atherogenic index of plasma (AIP) significantly increases the risk of kidney stones. Each standard deviation increase in AIP is associated with a 10% higher risk of nephrolithiasis. The study suggests incorporating AIP assessment into management strategies for kidney stone prevention.
sj-pdf-6-han-10.1177_15589447211028925 – Supplemental material for Versatility of the Posterior Interosseous Artery Flap: Emphasis on Powering Up the Toe Transfer
Creators: name: Lee, GiJun
name: Kim, BumSik
name: Jeon, Neunghan
name: Yoon, JungSoo
name: Hong, Ki Yong
name: Lim, SooA
name: Eo, SuRak
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Medicine
subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-6-han-10.1177_15589447211028925 for Versatility of the Posterior Interosseous Artery Flap: Emphasis on Powering Up the Toe Transfer by GiJun Lee, BumSik Kim, Neunghan Jeon, JungSoo Yoon, Ki Yong Hong, SooA Lim and SuRak Eo in HAND