cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Lack of effect of opioid peptides, morphine and naloxone on superoxide formation in human neutrophils and HL-60 leukemic cells
Creators: name: Seifert, Roland
name: Burde, R.
name: Schultz, Günter
Publisher: name: Universität Regensburg
Year: 1989
Subjects: subject: 610 Medizin
subject: 615 Pharmazie
subject: Adenosine Triphosphate/pharmacology
subject: Alprostadil/pharmacology
subject: Biotransformation/drug effects
subject: Endorphins/pharmacology
subject: Enkephalin, Methionine/pharmacology
subject: Humans
subject: Leukemia, Experimental/metabolism
subject: Morphine/pharmacology
subject: N-Formylmethionine Leucyl-Phenylalanine/pharmacology
subject: Naloxone/pharmacology
subject: Neutrophils/metabolism
subject: Oxygen Consumption/drug effects
subject: Platelet Activating Factor/pharmacology
subject: Superoxides/metabolism
subject: Tumor Cells, Cultured/drug effects

description: There are controversial reports in the literature concerning the effects of opioids on superoxide (O2-) formation in phagocytes, these agents being either inhibitory or stimulatory. We re-examined this issue and compared the effects of the chemotactic peptide, N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMet-Leu-Phe), phorbol myristate acetate (PMA), ATP, platelet activating factor (PAF), cytochalasin B (CB) and prostaglandin E1 (PGE1) with those of various opioids on O2- formation in human neutrophils and HL-60 leukemic cells under defined experimental conditions. In the presence of CB, fMet-Leu-Phe and PAF concentration-dependently activated O2- formation in neutrophils with EC50 values of 20 nM and 100 nM, respectively. In the absence of CB, fMet-Leu-Phe and PAF were much less effective. PAF synergistically enhanced O2- formation induced by fMet-Leu-Phe. ATP at a concentration of 100 microM and the opioids, methionine enkephalin, beta-endorphin, dynorphin, [D-Ala2, N-Me-Phe4, Gly5-ol]-enkephalin, [D-Ala2-D-Leu5]-enkephalin and morphine at concentrations between 10 pM to 1 microM did not activate O2- formation. ATP but not beta-endorphin potentiated fMet-Leu-Phe-induced O2- formation. O2- formation induced by a maximally stimulatory concentration of PMA (100 ng/ml) was enhanced by fMet-Leu-Phe but was unaffected by methionine enkephalin or PGE1. PMA at a non-stimulatory concentration (2 ng/ml) potentiated the effect of fMet-Leu-Phe but did not induce responsiveness to PAF, ATP or beta-endorphin. PGE1 strongly inhibited fMet-Leu-Phe-induced O2- formation, whereas morphine, methionine enkephalin and the opioid antagonist, naloxone, were without effect.(ABSTRACT TRUNCATED AT 250 WORDS)
A PMU Scheduling Scheme for Transmission of Synchrophasor Data in Electric Power Systems
Creators: name: Nagananda, K. G.
name: Kishore, Shalinee
name: Blum, Rick S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: With the proposition to install a large number of phasor measurement units (PMUs) in the future power grid, it is essential to provide robust communications infrastructure for phasor data across the network. We make progress in this direction by devising a simple time division multiplexing scheme for transmitting phasor data from the PMUs to a central server: Time is divided into frames and the PMUs take turns to transmit to the control center within the time frame. The main contribution of this work is a scheduling policy based on which PMU transmissions are ordered during a time frame. The scheduling scheme is independent of the approach taken to solve the PMU placement problem, and unlike strategies devised for conventional communications, it is intended for the power network since it is fully governed by the measure of electrical connectedness between buses in the grid. To quantify the performance of the scheduling scheme, we couple it with a fault detection algorithm used to detect changes in the susceptance parameters in the grid. Results demonstrate that scheduling the PMU transmissions leads to an improved performance of the fault detection scheme compared to PMUs transmitting at random.
description: 9 pages, 6 figures; an extra figure included in the published version. appears in IEEE Transactions on Smart Grid, Special Issue on Cyber Physical Systems and Security for Smart Grid, 2015
DEFORMATIONAL BEHAVIOR OF FIBER REINFORCED CEMENT BASED MATERIALS UNDER REPEATED LOADING
Creators: name: Zede
Publisher: name: Zede Journal of Ethiopian Engineers and Architects
Year: 2024

description: Bond degradation of the constitutematerials of the structure causes an increase in residual deflection and total surface crack width which reduces overall performance of structures. Advanced construction materials such as ultra-high strength fiber-reinforced concrete,commonly known as engineered cementitious composite (ECC) and fiber reinforced strain-hardening cement-based composites (SHCC)are designed to offer superior mechanical properties with multiple fine cracks and deformability than conventional concrete materials because of the bridging effect of embedded fibers. In general, both ECC and SHCC can be suitable for applications involving repeated loadings. However, the performance depends on magnitude, type of loads, etc. In this study, deformational behavior of fiber reinforced cement-based materials, ECC and SHCC, under repeated loading (low cycle fatigue) is investigated. Test results showed that, ECC is bendable, the deformation can be easily detected and has high impact resistance. On the other hand, SHCC has the potential for multiple cracking and strain-hardening behavior. ECC and SHCC can thus be used for strengthening and retrofitting of structural  lements in addition to their benefits for new construction works.
description: Zede Journal of Ethiopian Engineers and Architects, Vol. 42 (2024): Zede Journal of Ethiopian Engineers and Architects
Observation of spin-polarized surface states in a nodal line semimetal SnTaS$_{2}$
Creators: name: Song, Chunyao
name: Liu, Lulu
name: Cui, Shengtao
name: Gao, Jingjing
name: Song, Pengbo
name: Jin, Lei
name: Zhao, Wenjuan
name: Sun, Zhe
name: Zhang, Xiaoming
name: Zhao, Lin
name: Luo, Xuan
name: Sun, Yuping
name: Shi, Youguo
name: Zhang, Haijun
name: Liu, Guodong
name: Zhou, X. J.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The superconductor SnTaS$_{2}$ is theoretically predicted to be an intriguing topological nodal line semimetal without consideration of spin-orbit coupling. By carrying out angle-resolved photoemission (ARPES) and spin-resolved ARPES measurements combined with band structure calculations, we have provided a complete picture of the electronic structure and spin polarization property for the prominent surface states of SnTaS$_{2}$. The low-energy electronic states are dominated by surface states; two of them are from the S-terminated surface, while four of them are from the Sn-terminated surface. These give rise to interesting Fermi surface topology of SnTaS$_{2}$: three pockets located at $\barΓ$, $\bar{M}$ and $\bar{K}$ for the S-terminated surface and two pockets surrounding $\barΓ$ and $\bar{K}$ for the Sn-terminated surface. We further reveal that two surface states that cross the Fermi level are spin-polarized. Since SnTaS$_{2}$ is also a superconductor, our observations indicate that it may provide a new platform to explore topological superconductivity and other exotic properties.
If there were water: prehistoric settlement patterns in the Victorian Mallee
Creators: name: Ross, Anne
Publisher: name: Zenodo
Year: 1984
Subjects: Sahul
Archaeology
Radiocarbon
SahulArch
OCTOPUS database

description: What the Thunder said: 'If there were water' the Thunder said, there are a number of things we could do, particularly 'stop and drink'. Without water 'one cannot stop or think ... one can neither stand nor lie nor sit'. With aridity there is sterility - 'thunder without rain' no life. The Thunder in T. S. Eliot's poem from The Waste Land (1922) was making a number of assumptions about human responses to plenty and drought. Many anthropologists and archaeologists studying hunter­ gatherer settlement patterns have made, and still make, very similar assumptions. Their arguments, like the Thunder's, rely on the premise that where people will 'stop' in the landscape, and leave archaeological remains, depends largely upon ecological parameters, particularly the presence of water. In this thesis this fundamental assumption will be tested by a consideration of the prehistoric settlement patterns of the Aborigines of north western Victoria. ...
description: A thesis submitted to Macquarie University in fulfilment of the requirements for the degree of Doctor of Philosophy. 1984.
G-protein alpha-subunits in cytosolic and membranous fractions of human neutrophils
Creators: name: Rudolph, U.
name: Koesling, D.
name: Hinsch, K. D.
name: Seifert, Roland
name: Bigalke, M.
name: Schultz, Günter
name: Rosenthal, W.
Publisher: name: Universität Regensburg
Year: 1989
Subjects: subject: 610 Medizin
subject: 615 Pharmazie
subject: Cell Membrane/ultrastructure
subject: Centrifugation, Density Gradient
subject: Cytosol/analysis
subject: Electrophoresis, Polyacrylamide Gel
subject: GTP-Binding Proteins/analysis
subject: Humans
subject: Immunoblotting
subject: Neutrophils/ultrastructure

description: In plasma membranes of human neutrophils, we identified two major pertussis toxin substrates of 40 kDa Mr with pI values of 5.30 and 5.37. Only the acidic of the two substrates was also present in neutrophil cytosol. Two-dimensional tryptic peptide maps revealed a high degree of homology of cytosolic and particulate substrates. Purified G-protein beta gamma-complex stimulated pertussis toxin-catalyzed [32P]ADP-ribosylation of membranous and cytosolic substrates of neutrophils less than 2-fold and 6-fold, respectively. Hydrodynamic properties of the cytosolic substrate strongly suggested that it exists as a monomer. Purified G-protein beta gamma-complex increased the s20,w value of the cytosolic substrate from 3.3 S to 4.0 S. The GTP analogue, guanosine 5'-O-(3-thiotriphosphate), promoted the release of pertussis toxin substrates from plasma membranes. An antiserum raised against a sequence specific for the Gi2 alpha-subunit reacted with 39-40 kDa proteins in plasma membranes and with an apparently single 40 kDa protein in cytosol. We conclude that neutrophil cytosol contains monomeric Gi2 alpha-subunits which--by interacting with hydrophobic beta gamma-complexes--may reversibly bind to the plasma membrane.
Manifest causality in quantum field theory with sources and detectors
Creators: name: Dickinson, Robert
name: Forshaw, Jeff
name: Millington, Peter
name: Cox, Brian
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We introduce a way to compute scattering amplitudes in quantum field theory including the effects of particle production and detection. Our amplitudes are manifestly causal, by which we mean that the source and detector are always linked by a connected chain of retarded propagators. We show how these amplitudes can be derived from a path integral, using the Schwinger-Keldysh "in-in" formalism. Focussing on phi-cubed theory, we confirm that our approach agrees with the standard S-matrix approach in the case of positive energy plane-wave scattering.
description: 24 pages; 6 figures; version accepted for publication in JHEP
RELIABILITY-BASED NUMERICAL MODELING FOR INVESTIGATION OF THE IMPACT OF PRINTING PARAMETERS ON BUILDABILITY OF 3D PRINTED CONCRETE STRUCTURES
Creators: name: Zede
Publisher: name: Zede Journal of Ethiopian Engineers and Architects
Year: 2024

description: The significance of 3D concrete printing (3DCP) as an additive manufacturing technology has increased over the past few years. Both academic research studies and large-scale industrial realizations of 3DCP have shown that it represents a viable alternative to traditional concrete mold casting. The key reason for this rapid development is that urgent challenges of the construction sector, in particular sustainability and productivity, are addressed. However, previous studies on technological progress have mainly been experimentally driven. The introduction of appropriate numerical modeling techniques would, therefore, further foster the success of 3DCP by providing insight into the structural behavior, which is beyond experimental possibilities. The present study introduces a numerical modeling technique for the analysis of 3DCP wall structures using a time-dependent reliability analysis. Uncertainties occurring throughout the printing process and time dependent properties of printable concreteare considered. In addition, sensitivity analysis of random variables is done, which could be used as indicative preference for future process optimizations.The results yield valuable insight into the influence of printing process parameters on the failure of 3D printed concrete structures. The numerical model predicts build ability of a 3D printed concrete wall structure as it is in very good agreement with experimental results of similar studies.
description: Zede Journal of Ethiopian Engineers and Architects, Vol. 42 (2024): Zede Journal of Ethiopian Engineers and Architects
Spectroscopic Evidence for Dirac Nodal Surfaces and Nodal Rings in Superconductor NaAlSi
Creators: name: Song, Chunyao
name: Jin, Lei
name: Song, Pengbo
name: Rong, Hongtao
name: Zhu, Wenpei
name: Liang, Bo
name: Cui, Shengtao
name: Sun, Zhe
name: Zhao, Lin
name: Shi, Youguo
name: Zhang, Xiaoming
name: Liu, Guodong
name: Zhou, X. J.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: The discovery of the topological states has become a key topic in condensed matter physics with the focus evolving from the Dirac or Weyl points to high-dimension topological states of the nodal lines and nodal surfaces. For a topological material to manifest its quantum properties and become useful in applications, the topological states need to be genuine and clean so that they lie close to the Fermi level without other trivial bands existing at the Fermi level. While a number of high-dimension topological materials are predicted, only a few of them have been synthesized and confirmed and the genuine and clean ones are especially scarce. Here we report the realization of the genuine clean multiple high-dimension topological states in NaAlSi. By performing high-resolution angle-resolved photoemission measurements and band structure calculations, we have observed two sets of nodal surfaces and the formation of two homocentric nodal ring states in NaAlSi. The observed nodal rings are distinct in that the inner one is a type-{\uppercase\expandafter{\romannumeral1}} nodal ring while the outer one is a type-{\uppercase\expandafter{\romannumeral1}} nodal ring embedded with four type-{\uppercase\expandafter{\romannumeral3}} nodal points. All the bands involved in the nodal rings lie very close to the Fermi level with no other trivial bands coexisting at the Fermi level. These observations make NaAlSi a desirable topological material to explore for novel quantum states and exotic properties.
Cosmological observables in multi-field inflation with a non-flat field space
Creators: name: Gao, Xin
name: Li, Tianjun
name: Shukla, Pramod
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Using $δN$ formalism, in the context of a generic multi-field inflation driven on a non-flat field space background, we revisit the analytic expressions of the various cosmological observables such as scalar/tensor power spectra, scalar/tensor spectral tilts, non-Gaussianity parameters, tensor-to-scalar ratio, and the various runnings of these observables. In our backward formalism approach, the subsequent expressions of observables automatically include terms beyond the leading order slow-roll expansion correcting many of the expression at subleading order. To connect our analysis properly with the earlier results, we rederive the (well) known (single field) expressions in the limiting cases of our generic formulae. Further, in the light of PLANCK results, we examine for the compatibility of the consistency relations within the slow-roll regime of a two-field roulette poly-instanton inflation realized in the context of large volume scenarios.
description: version 2, 32 pages, 1 table and 12 figures, major revision as per referee's suggestions, to appear in JCAP
EVALUATION OF PUBLIC BUS STOPS LOCATION AND SPACING (THE CASE OF SELECTED ROUTES OF ANBESSA CITY BUS SERVICE ENTERPRISE)
Creators: name: Zede
Publisher: name: Zede Journal of Ethiopian Engineers and Architects
Year: 2024

description: Currently, the primary challenges in Addis Ababa include traffic accidents, comfort issues,
travel delays, and productivity problems for travelers. To address these issues, it is recommended to enhance public services by incorporating suitable geometric features,
particularly for bus stops. This study focused on evaluating existing bus stop locations and
spacing and put remedial measure for any existing drawbacks on public transport Road
networks particular on Anbessa City Bus Service Enterprise (ACBSE) routes. Observation, field measurement, GPS method tracking location of bus stops and GIS method produced point mapping were the methodologies used for the study. Travel speed, bus stop location, its configuration and service coverage radius data were acquired. The maximum travel speed that was determined during the study period was 26km/hr. Based on the analysis result, 29% of Mid-Block pullout bus stops should be changed to mid-block curb-side and mid-block bus bulb bus stops on street having vehicle parking. Generally, 8% of bus stop locations needs future modification. From the research finding, the final bus stops location and spacing depend on the combined effect of location with respect to the nearest
intersection, travel speed, service coverage radius, topographical limitation, safety issues
and passenger loading of the surrounding area.
description: Zede Journal of Ethiopian Engineers and Architects, Vol. 42 (2024): Zede Journal of Ethiopian Engineers and Architects
Aboriginal Occupation of Lizard Island
Creators: name: Mills, R. A.
Publisher: name: Zenodo
Year: 1992
Subjects: Sahul
Archaeology
Radiocarbon
SahulArch
OCTOPUS database

description: The research began as the result of a camping holiday to Lizard Island during which Aboriginal midden sites and some stone arrangements were observed. Little acknowledgement of this fact was evident at the Cooktown Museum or on the island itself. ...
description: Master's thesis. 120 p
Activation of superoxide formation and lysozyme release in human neutrophils by the synthetic lipopeptide Pam3Cys-Ser-(Lys)4. Involvement of guanine-nucleotide-binding proteins and synergism with chemotactic peptides
Creators: name: Seifert, Roland
name: Schultz, Günter
name: Richter-Freund, M.
name: Metzger, J.
name: Wiesmüller, K. H.
name: Jung, G.
name: Bessler, W. G.
name: Hauschildt, S.
Publisher: name: Universität Regensburg
Year: 1990
Subjects: subject: 610 Medizin
subject: 615 Pharmazie
subject: Dose-Response Relationship, Drug
subject: Drug Synergism
subject: Exocytosis/drug effects
subject: GTP-Binding Proteins/physiology
subject: Humans
subject: Lipoproteins/pharmacology
subject: Muramidase/secretion
subject: N-Formylmethionine Leucyl-Phenylalanine/pharmacology
subject: Neutrophils/metabolism
subject: Oligopeptides/pharmacology
subject: Platelet Activating Factor/pharmacology
subject: Structure-Activity Relationship
subject: Superoxides/metabolism
subject: Tumor Necrosis Factor-alpha/pharmacology

description: Upon exposure to the bacterial chemotactic peptide fMet-Leu-Phe, human neutrophils release lysozyme and generate superoxide anions (O2.-). The synthetic lipoamino acid N-palmitoyl-S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-(R)-cysteine (Pam3Cys), which is derived from the N-terminus of bacterial lipoprotein, when attached to Ser-(Lys)4 [giving Pam3Cys-Ser-(Lys)4], activated O2.- formation and lysozyme release in human neutrophils with an effectiveness amounting to about 15% of that of fMet-Leu-Phe. Palmitic acid, muramyl dipeptide, lipopolysaccharide and the lipopeptides Pam3Cys-Ala-Gly, Pam3Cys-Ser-Gly, Pam3Cys-Ser, Pam3Cys-OMe and Pam3Cys-OH did not activate O2.- formation. Pertussis toxin, which ADP-ribosylates guanine-nucleotide-binding proteins (G-proteins) and functionally uncouples formyl peptide receptors from G-proteins, prevented activation of O2.- formation by fMet-Leu-Phe and inhibited Pam3Cys-Ser-(Lys)4-induced O2.- formation by 85%. Lipopeptide-induced exocytosis was pertussis-toxin-insensitive. O2.- formation induced by Pam3Cys-Ser-(Lys)4 and fMet-Leu-Phe was enhanced by cytochalasin B, by a phorbol ester and by a diacylglycerol kinase inhibitor. Addition of activators of adenylate cyclase and removal of extracellular Ca2+ inhibited O2.- formation by fMet-Leu-Phe and Pam3Cys-Ser-(Lys)4 to different extents. Pam3Cys-Ser-(Lys)4 synergistically enhanced fMet-Leu-Phe-induced O2.- formation and primed neutrophils to respond to the chemotactic peptide at non-stimulatory concentrations. Our data suggest the following. (1) Pam3Cys-Ser-(Lys)4 activates neutrophils through G-proteins, involving pertussis-toxin-sensitive and -insensitive processes. (2) The signal transduction pathways activated by fMet-Leu-Phe and Pam3Cys-Ser-(Lys)4 are similar but not identical. (3) In inflammatory processes, bacterial lipoproteins and chemotactic peptides may interact synergistically to activate O2.- formation, leading to enhanced bactericidal activity.
Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides
Creators: name: Seifert, Roland
name: Burde, R.
name: Schultz, Günter
Publisher: name: Universität Regensburg
Year: 1989
Subjects: subject: 610 Medizin
subject: 615 Pharmazie
subject: Adenosine Triphosphate/pharmacology
subject: Bucladesine
subject: Enzyme Activation/drug effects
subject: GTP-Binding Proteins/physiology
subject: Humans
subject: N-Formylmethionine Leucyl-Phenylalanine/pharmacology
subject: NADH, NADPH Oxidoreductases/metabolism
subject: NADPH Oxidase
subject: Neutrophils/enzymology
subject: Superoxides/metabolism
subject: Tumor Cells, Cultured/enzymology
subject: Uracil Nucleotides/pharmacology
subject: Uridine Triphosphate/pharmacology

description: Human neutrophils and HL-60 leukaemic cells possess an NADPH oxidase which catalyses superoxide (O2-) formation and is activated by the chemotactic peptide, N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMet-Leu-Phe). In dibutyryl cyclic AMP-differentiated HL-60 cells, ATP and UTP in the presence of cytochalasin B activated O2- formation with EC50 values of 5 microM and efficacies amounting to 30% of that of fMet-Leu-Phe. The potency order of purine nucleotides in activating O2- generation was ATP = adenosine 5'-O-(3-thiotriphosphate) greater than ITP greater than dATP = ADP. Pyrimidine nucleotides activated NADPH oxidase in the potency order UTP greater than dUTP greater than CTP = TTP = UDP. Pertussis toxin completely prevented activation of NADPH oxidase by fMet-Leu-Phe and UTP, whereas the effect of ATP was only partially inhibited. ATP and UTP enhanced O2- generation induced by fMet-Leu-Phe by up to 8-fold, and primed the cells to respond to non-stimulatory concentrations of fMet-Leu-Phe. Activation of NADPH oxidase by UTP but not by ATP was inhibited by various activators of adenylate cyclase. In dimethyl sulphoxide-differentiated HL-60 cells and in human neutrophils, ATP and UTP per se did not activate NADPH oxidase, but they potentiated the effect of fMet-Leu-Phe. Our results suggest that purine and pyrimidine nucleotides act via purino- and novel pyrimidinoceptors respectively, which are coupled to guanine nucleotide-binding proteins leading to the activation of NADPH oxidase. As ATP and UTP are released from cells under physiological and pathological conditions, these nucleotides may play roles as intercellular signal molecules in the activation of O2- formation.
Proposal for Resonant Detection of Relic Massive Neutrinos
Creators: name: Birrell, Jeremiah
name: Rafelski, Johann
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We present a novel method for detecting the relic neutrino background that takes advantage of structured quantum degeneracy to amplify the drag force from neutrinos scattering off a detector. Developing this idea, we present a characterization of the present day relic neutrino distribution in an arbitrary frame, including the influence of neutrino mass and neutrino reheating by $e^+e^-$ annihilation. We present explicitly the neutrino velocity and de Broglie wavelength distributions for the case of an Earthbound observer. Considering that relic neutrinos could exhibit quantum liquid features at the present day temperature and density, we discuss the impact of neutrino fluid correlations on the possibility of resonant detection.
description: 8 pages, 8 figures, to appear in European Physical Journal C
Analysis by high-resolution two-dimensional electrophoresis of differentiation-dependent alterations in cytosolic protein pattern of HL-60 leukemic cells
Creators: name: Jungblut, P. R.
name: Seifert, Roland
Publisher: name: Universität Regensburg
Year: 1990
Subjects: subject: 610 Medizin
subject: 615 Pharmazie
subject: Calcitriol/pharmacology
subject: Cell Differentiation/drug effects
subject: Cytosol/chemistry
subject: Electrophoresis, Gel, Two-Dimensional
subject: Humans
subject: Leukemia/pathology
subject: Neutrophils/chemistry
subject: Proteins/analysis
subject: Silver
subject: Staining and Labeling
subject: Tretinoin/pharmacology
subject: Tumor Cells, Cultured/drug effects

description: HL-60 leukemic cells were differentiated along the neutrophilic pathway with retinoic acid (RA) or along the monocytic pathway with 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). Using a high-resolution two-dimensional electrophoresis technique and subsequent silver staining, differentiation-dependent changes in cytosolic protein pattern of HL-60 cells were analysed and were compared with the cytosolic protein pattern of human neutrophils. The amount of 64 and 50 out of a total of 632 proteins studied was increased or decreased in RA- and 1,25(OH)2D3-differentiated HL-60 cells, respectively, in comparison to undifferentiated HL-60 cells. Thirty-three of these proteins were similarly altered in RA- and 1,25(OH)2D3-differentiated HL-60 cells. Twenty-two and 25 of the proteins altered in amount in RA- or 1,25(OH)2D3-differentiated HL-60 cells versus undifferentiated HL-60 cells were similarly altered in human neutrophils in comparison to undifferentiated HL-60 cells. Seven and 10 of the proteins altered in amount in RA- or 1,25(OH)2D3-differentiated HL-60 cells had specific equivalents in neutrophil cytosol. Our results show (i) that neutrophilic and monocytic differentiation is associated with decreases and increases in amount of cytosolic proteins; (ii) that both differentiation processes share a common set of alterations; and (iii) are associated with specific alterations in protein amount.
Seasonality and shellfishing at Discovery Bay, Victoria
Creators: name: Godfrey, Michael C. S.
Publisher: name: Zenodo
Year: 1984
Subjects: Sahul
Archaeology
Radiocarbon
SahulArch
OCTOPUS database

description: The Study Area, the Discovery Bay Coastal Park, is located between Cape Bridgewater and the Victorian-South Australian border. Archaeological surveys have indicated there are hundreds of Aboriginal shell middens in this area. I originally came to the Study Area to undertake an archaeological management report for the National Parks Service of Victoria. It was because of my familiarity with the area, and its research potential, that I stayed on to undertake this study. ...
description: 266 p
Baryon Acoustic Oscillations in the Lyα forest of BOSS DR11 quasars
Creators: name: Delubac, Timothée
name: Bautista, Julian E.
name: Busca, Nicolás G.
name: Rich, James
name: Kirkby, David
name: Bailey, Stephen
name: Font-Ribera, Andreu
name: Slosar, Anže
name: Lee, Khee-Gan
name: Pieri, Matthew M.
name: Hamilton, Jean-Christophe
name: Aubourg, Éric
name: Blomqvist, Michael
name: Bovy, Jo
name: Brinkmann, J.
name: Carithers, William
name: Dawson, Kyle S.
name: Eisenstein, Daniel J.
name: Gontcho, Satya Gontcho A
name: Kneib, Jean-Paul
name: Goff, J. -M. Le
name: Margala, Daniel
name: Miralda-Escudé, Jordi
name: Myers, Adam D.
name: Nichol, Robert C.
name: Noterdaeme, Pasquier
name: O'Connell, Ross
name: Olmstead, Matthew D.
name: Palanque-Delabrouille, Nathalie
name: Pâris, Isabelle
name: Petitjean, Patrick
name: Ross, Nicholas P.
name: Rossi, Graziano
name: Schlegel, David J.
name: Schneider, Donald P.
name: Weinberg, David H.
name: Yèche, Christophe
name: York, Donald G.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We report a detection of the baryon acoustic oscillation (BAO) feature in the flux-correlation function of the Lyα forest of high-redshift quasars with a statistical significance of five standard deviations. The study uses 137,562 quasars in the redshift range $2.1\le z \le 3.5$ from the Data Release 11 (DR11) of the Baryon Oscillation Spectroscopic Survey (BOSS) of SDSS-III. This sample contains three times the number of quasars used in previous studies. The measured position of the BAO peak determines the angular distance, $D_A(z=2.34)$ and expansion rate, $H(z=2.34)$, both on a scale set by the sound horizon at the drag epoch, $r_d$. We find $D_A/r_d=11.28\pm0.65(1σ)^{+2.8}_{-1.2}(2σ)$ and $D_H/r_d=9.18\pm0.28(1σ)\pm0.6(2σ)$ where $D_H=c/H$. The optimal combination, $\sim D_H^{0.7}D_A^{0.3}/r_d$ is determined with a precision of $\sim2\%$. For the value $r_d=147.4~{\rm Mpc}$, consistent with the CMB power spectrum measured by Planck, we find $D_A(z=2.34)=1662\pm96(1σ)~{\rm Mpc}$ and $H(z=2.34)=222\pm7(1σ)~{\rm km\,s^{-1}Mpc^{-1}}$. Tests with mock catalogs and variations of our analysis procedure have revealed no systematic uncertainties comparable to our statistical errors. Our results agree with the previously reported BAO measurement at the same redshift using the quasar-Lyα forest cross-correlation. The auto-correlation and cross-correlation approaches are complementary because of the quite different impact of redshift-space distortion on the two measurements. The combined constraints from the two correlation functions imply values of $D_A/r_d$ and $D_H/r_d$ that are, respectively, 7% low and 7% high compared to the predictions of a flat $Λ$CDM cosmological model with the best-fit Planck parameters. With our estimated statistical errors, the significance of this discrepancy is $\approx 2.5σ$.
description: Accepted for publication in A&A. 17 pages, 18 figures
(In)direct Detection of Boosted Dark Matter
Creators: name: Agashe, Kaustubh
name: Cui, Yanou
name: Necib, Lina
name: Thaler, Jesse
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We initiate the study of novel thermal dark matter (DM) scenarios where present-day annihilation of DM in the galactic center produces boosted stable particles in the dark sector. These stable particles are typically a subdominant DM component, but because they are produced with a large Lorentz boost in this process, they can be detected in large volume terrestrial experiments via neutral-current-like interactions with electrons or nuclei. This novel DM signal thus combines the production mechanism associated with indirect detection experiments (i.e. galactic DM annihilation) with the detection mechanism associated with direct detection experiments (i.e. DM scattering off terrestrial targets). Such processes are generically present in multi-component DM scenarios or those with non-minimal DM stabilization symmetries. As a proof of concept, we present a model of two-component thermal relic DM, where the dominant heavy DM species has no tree-level interactions with the standard model and thus largely evades direct and indirect DM bounds. Instead, its thermal relic abundance is set by annihilation into a subdominant lighter DM species, and the latter can be detected in the boosted channel via the same annihilation process occurring today. Especially for dark sector masses in the 10 MeV-10 GeV range, the most promising signals are electron scattering events pointing toward the galactic center. These can be detected in experiments designed for neutrino physics or proton decay, in particular Super-K and its upgrade Hyper-K, as well as the PINGU/MICA extensions of IceCube. This boosted DM phenomenon highlights the distinctive signatures possible from non-minimal dark sectors.
description: 40 pages, 11 figures, 1 table; v2: references added, appendix B revised; v3: improved presentation of signal/background, added section 4.4 on earth attenuation, version to appear in JCAP; v4: typos fixed, appendix B bounds weakened, conclusions unchanged
The Value of Internships for Students’ Psychological Needs
Creators: name: Ng, Lee Keng
name: Soh, Vanessa
name: Hui-Ying Lim, Clara
name: Yi-Xuan Seow, Geraldine
name: Xinwei Tan, Juline
name: Pei-Yi Ann, Clara
Publisher: name: Singapore Institute of Technology
Year: 2024
Subjects: classificationCode: 350402
subject: Hospitality management

description: Internships are commonly used in degree programmes to expose students to the real-world applications of theories and to nurture students for their future careers. However, there is a current research gap about students' perceptions regarding the value of internships, particularly the fulfilment of their psychological needs. It was found that meeting students' psychological needs during their internships can enhance their well-being, motivation and engagement in work. This will subsequently affect their performance and eventually their career decisions. This study was conducted to examine students’ psychological needs in internships in the context of a university in Singapore. A mixed-method approach was used to collect qualitative and quantitative data from 12 interviewees and 82 respondents respectively. This study also incorporated the self-determination theory that emphasises the importance of fulfilling psychological needs. The theory highlights three individual psychological needs of autonomy, competency and relatedness. The research outcome shows that all three psychological needs are important to students. However, while the needs are fulfilled frequently enough in internships, there are areas that the university and the industry organisations can improve in. The recommendations include curriculum review, structured feedback sessions with academic supervisors, formalised mentorship arrangement and more cross-departmental skill development opportunities. These combined improvements can collectively lead to a more supportive learning journey for students and a better retention of talents for the industry.
Entanglement distillation for quantum communication network with atomic-ensemble memories
Creators: name: Li, Tao
name: Yang, Guo-Jian
name: Deng, Fu-Guo
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Atomic ensembles are effective memory nodes for quantum communication network due to the long coherence time and the collective enhancement effect for the nonlinear interaction between an ensemble and a photon. Here we investigate the possibility of achieving the entanglement distillation for nonlocal atomic ensembles by the input-output process of a single photon as a result of cavity quantum electrodynamics. We give an optimal entanglement concentration protocol (ECP) for two-atomic-ensemble systems in a partially entangled pure state with known parameters and an efficient ECP for the systems in an unknown partially entangled pure state with a nondestructive parity-check detector (PCD). For the systems in a mixed entangled state, we introduce an entanglement purification protocol with PCDs. These entanglement distillation protocols have high fidelity and efficiency with current experimental techniques, and they are useful for quantum communication network with atomic-ensemble memories.
description: 13 pages, 7 figures, one column
Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells
Creators: name: Offermanns, S.
name: Seifert, Roland
name: Metzger, J. W.
name: Jung, G.
name: Lieberknecht, A.
name: Schmidt, U.
name: Schultz, Günter
Publisher: name: Universität Regensburg
Year: 1992
Subjects: subject: 615 Pharmazie
subject: Blotting, Western
subject: Bucladesine/pharmacology
subject: Cell Differentiation/drug effects
subject: Cells, Cultured
subject: Electrophoresis, Polyacrylamide Gel
subject: Genistein
subject: Humans
subject: Isoflavones/pharmacology
subject: Lipoproteins/pharmacology
subject: Neutrophils/metabolism
subject: Pertussis Toxin
subject: Phosphorylation/drug effects
subject: Tetradecanoylphorbol Acetate/pharmacology
subject: Tyrosine/metabolism
subject: Virulence Factors, Bordetella/pharmacology

description: Synthetic lipopeptide analogues of the N-terminus of bacterial lipoprotein are effective activators of macrophages, neutrophils and lymphocytes. We studied the effect of the lipopeptide N-palmitoyl-S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]- (R)-cysteinyl-(S)-seryl-(S)-lysyl-(S)-lysyl-(S)-lysyl-(S)-lysine [Pam3Cys-Ser-(Lys)4] on tyrosine phosphorylation in dibutyryl-cyclic-AMP-differentiated HL-60 cells, using anti-phosphotyrosine antibodies. Pam3Cys-Ser-(Lys)4 concentration-dependently stimulated tyrosine phosphorylation of 100/110 kDa and 60 kDa proteins and, to a lesser extent, of 55 kDa and 70/75 kDa proteins. Half-maximal and maximal effects were observed at concentrations of 1-6 and 5-50 micrograms/ml respectively. The lipopeptide-induced increase in phosphorylation was rapid and transient, with a peak response after 30-60 s. The lipopeptide (2S)-2-palmitoylamino-6-palmitoyloxymethyl-7-palmitoyloxy heptanoyl-Ser-(Lys)4 [Pam3Ahh-Ser-(Lys)4] was as potent as Pam3Cys-Ser(Lys)4, whereas (2S,6S)-2-palmitoylamino-6,7-bis(palmitoyloxy)heptanoyl++ +-Ser-(Lys)4 [Pam3Adh-Ser-(Lys)4] and Pam3Cys-Ser-Gly did not induce tyrosine phosphorylation. Lipopeptide-induced tyrosine phosphorylation was not affected by treatment of cells with pertussis toxin. Neither phorbol 12-myristate 13-acetate nor A23187 induced tyrosine phosphorylation in dibutyryl-cyclic-AMP-differentiated HL-60 cells. In HL-60 promyelocytes, Pam3Cys-Ser-(Lys)4 had no effect on tyrosine phosphorylation, whereas the lipopeptide also induced tyrosine phosphorylation in 1,25-dihydroxyvitamin-D3-differentiated HL-60 cells and in human neutrophils. These results show that lipopeptides are effective stimulators of tyrosine phosphorylation in mature human myeloid cells.
Accidentes en el tránsito con participación de vehículos policiales pertenecientes a la prefectura santiago oriente, durante los años 2019 2020
Creators: name: Bustamante Arce, Elizabeth Andrea
name: Gallardo Carreño, Laura Vanessa
name: Segura, Nancy Zamorano
Publisher: name: Zenodo
Year: 2023
Subjects: accidentes de tránsito
vehículos policiales
Prefectura Santiago Oriente

description: En la presente investigación, se estudia la participación de vehículos policiales en accidentes en el tránsito, pertenecientes a la Prefectura Santiago Oriente, durante los años 2019 y 2020 y analizar las circunstancias en que los vehículos policiales se ven involucrados en accidentes, especialmente las causas y las consecuencias que conllevan éstos y los efectos que tienen en el desarrollo de los procedimientos policiales. El diseño metodológico utilizado en el trabajo investigativo es cuantitativo, con énfasis en la descripción del fenómeno, acerca del comportamiento observado en estos accidentes en el tránsito, en que participaron vehículos policiales. La información documental, necesaria para llevarlo a cabo, se solicitó oportunamente, a la Sección de Investigación de Accidentes en el Tránsito, Sección de mediciones psicométricas de Carabineros de Chile y Comisión Nacional de Seguridad de Tránsito. Con los datos recopilados, se procedió a organizarlos en matrices, elaboradas especialmente para este trabajo, para luego describirlos y analizarlos. Finalmente, Se constató que, si bien hubo diferencia en el número y causas de accidentes entre los años estudiados, la mayoría de ellos tendrían una causa relacionada a la imprudencia en la conducción.
ЭТНИЧЕСКАЯ ЭКОЛОГИЯ
Creators: name: Ямсков А.Н.
Publisher: name: Zenodo
Year: 2018
Subjects: этноэкология, этническая экология, экологическое образование, географическое образование, этнологическое образование, программа курса

description: Примерная программа дисциплины "Этническая экология", предназначенная для студентов-географов и разработанная автором на основе опыта преподавания курса "Социальная экология и этноэкология" на Географическом факультете Московского городского педагогического университета в 1997-2014 гг.
Cosmological Perturbation Theory as a Tool for Estimating Box-Scale Effects in N-body Simulations
Creators: name: Orban, Chris
Publisher: name: arXiv
Year: 2013
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: In performing cosmological N-body simulations, it is widely appreciated that the growth of structure on the largest scales within a simulation box will be inhibited by the finite size of the simulation volume. Following ideas set forth in Seto (1999), this paper shows that standard (a.k.a. 1-loop) cosmological perturbation theory (SPT) can be used to predict, in an approximate way, the deleterious effect of the box scale on the power spectrum of density fluctuations in simulation volumes. Alternatively, this approach can be used to quickly estimate post facto the effect of the box scale on power spectrum results from existing simulations. In this way SPT can help determine whether larger box sizes or other more-sophisticated methods are needed to achieve a particular level of precision for a given application (e.g. simulations to measure the non-linear evolution of baryon acoustic oscillations). I focus on SPT in this note and show that its predictions differ only by about a factor of two or less from the measured suppression inferred from both powerlaw and $Λ$CDM $N$-body simulations. It should be possible to improve the accuracy of these predictions through using more-sophisticated perturbation theory models. An appendix compares power spectrum measurements from the powerlaw simulations at outputs where box-scale effects are minimal to perturbation theory models and previously-published fitting functions. These power spectrum measurements are included with this paper to aid efforts to develop new perturbation theory models.
description: 10 pages, 5 figures
Generation of specific antibodies against the rap1A, rap1B and rap2 small GTP-binding proteins. Analysis of rap and ras proteins in membranes from mammalian cells
Creators: name: Klinz, F. J.
name: Seifert, Roland
name: Schwaner, I.
name: Gausepohl, H.
name: Frank, R.
name: Schultz, Günter
Publisher: name: Universität Regensburg
Year: 1992
Subjects: subject: 615 Pharmazie
subject: Amino Acid Sequence
subject: Animals
subject: Antibodies
subject: Antibody Specificity
subject: Blood Platelets/chemistry
subject: Cell Line
subject: Cell Membrane/chemistry
subject: Cytosol/chemistry
subject: Electrophoresis, Polyacrylamide Gel
subject: Escherichia coli/genetics
subject: GTP-Binding Proteins/immunology
subject: Humans
subject: Immunoblotting
subject: Molecular Sequence Data
subject: Molecular Weight
subject: Proto-Oncogene Proteins/analysis
subject: Proto-Oncogene Proteins p21(ras)/genetics
subject: Rabbits/immunology
subject: Recombinant Proteins/immunology
subject: Sequence Homology, Nucleic Acid
subject: rap GTP-Binding Proteins

description: Specific antibodies against rap1A and rap1B small GTP-binding proteins were generated by immunization of rabbits with peptides derived from the C-terminus of the processed proteins. Immunoblot analysis of membranes from several mammalian cell lines and human thrombocytes with affinity-purified antibodies against rap1A or rap1B demonstrated the presence of multiple immunoreactive proteins in the 22-23 kDa range, although at strongly varying levels. Whereas both proteins were present in substantial amounts in membranes from myelocytic HL-60, K-562 and HEL cells, they were hardly detectable in membranes from lymphoma U-937 and S49.1 cyc- cells. Membranes from human thrombocytes and 3T3-Swiss Albino fibroblasts showed strong rap1B immunoreactivity, whereas rap1A protein was present in much lower amounts. In the cytosol of HL-60 cells, only small amounts of rap1A and rap1B proteins were detected, unless the cells were treated with lovastatin, an inhibitor of hydroxymethylglutaryl-coenzyme A reductase, suggesting that both proteins are isoprenylated. By comparison with recombinant proteins, the ratio of rap1A/ras proteins in membranes from HL-60 cells was estimated to be about 4:1. An antiserum directed against the C-terminus of rap2 reacted strongly with recombinant rap2, but not with membranes from tested mammalian cells. In conclusion, rap1A and rap1B proteins are distributed differentially among membranes from various mammalian cell types and are isoprenylated in HL-60 cells.
Some reflections on comments
Creators: name: Csabai, Istvan
name: Solymosi, Norbert
Publisher: name: Zenodo
Year: 2022
Subjects: SARS-CoV-2; genomics

description: Recently Csabai et al. have found a metagenomic sample set originally collected at Antarctica that most likely as a result of
 contamination contains traces of unique SARS-CoV-2 variants. Later on they identified putative host genomes. The preprints
 resulted a wide discussion in the news and social media and some comments on the preprint server or via private emails. Here
 we try to briefly reflect on some of them.
Probing the Higgs Couplings to Photons in $h\rightarrow 4\ell$ at the LHC
Creators: name: Chen, Yi
name: Harnik, Roni
name: Vega-Morales, Roberto
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We explore the sensitivity of the Higgs decay to four leptons, the so-called golden channel, to higher dimensional loop-induced couplings of the Higgs boson to $ZZ$, $Zγ$, and $γγ$, allowing for general CP mixtures. The larger standard model tree level coupling $hZ^μZ_μ$ is the dominant "background" for the loop induced couplings. However this large background interferes with the smaller loop induced couplings, enhancing the sensitivity. We perform a maximum likelihood analysis based on analytic expressions of the fully differential decay width for $h\to 4\ell$ ($4\ell \equiv 2e2μ, 4e, 4μ$) including all interference effects. We find that the spectral shapes induced by Higgs couplings to photons are particularly different than the $hZ^μZ_μ$ background leading to enhanced sensitivity to these couplings. We show that even if the $h\toγγ$ and $h\to 4\ell$ rates agree with that predicted by the Standard Model, the golden channel has the potential to probe both the CP nature as well as the overall sign of the Higgs coupling to photons well before the end of high-luminosity LHC running ($\sim$3 ab$^{-1}$).
description: References updated. Published in journal