cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: The effects of atomoxetine on odor detection, associative valence learning and reversal in rats
Creators: name: Abu-Labdeh, Ruhuf
Publisher: name: Memorial University of Newfoundland
publisherIdentifier: https://ror.org/04haebc03
publisherIdentifierScheme: ROR
Year: 2025

description: The locus coeruleus (LC) is a pivotal structure in supporting cognitive functions by releasing norepinephrine (NE). Neuronal deterioration closely correlates with decreased cognition during Alzheimer’s disease (AD). Given this, there is a growing interest in exploring interventions that enhance norepinephrine at synaptic levels. Atomoxetine (ATM) is a norepinephrine uptake inhibitor and a potential candidate for AD interventions. Understanding the potential therapeutic effects of NE-enhancing drugs in healthy subjects begins with characterizing their function. Olfactory impairment has been identified as one of the earliest symptoms of preclinical AD. In this study, we investigated the effects of aging on olfactory detection and discrimination learning, as well as the influence of ATM on olfactory associative learning and its potential cellular effects in both male and female Long-Evans rats. Results showed that aged (22-24 months old) rats exhibited comparable odor detection and discrimination learning abilities to adult (6-9 months old) rats. However, aged rats demonstrated impaired performance in olfactory reversal learning tasks. Interestingly, ATM administration at two different doses enhanced odor discrimination learning but hindered olfactory reversal learning and threat extinction in a dose-dependent manner in adult rats. Further analysis revealed that the learning enhancement induced by ATM is accompanied by a delayed phosphorylation of cyclic AMP-responsive element binding protein (CREB) in the posterior piriform cortex. In conclusion, the study reveals that the complex effects of ATM are influenced by target structures and suggest potential interactions with other neurotransmitters, revealing the complex mechanisms underlying its therapeutic potential in cognitive function.
Tettigonia viridissima
Creators: name: Skejo, Josip
name: Rebrina, Fran
name: Szövényi, Gergely
name: Puskás, Gellért
name: Tvrtković, Nikola
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Tettigoniidae
Tettigonia
Tettigonia viridissima

description: 74. Tettigonia viridissima (Linnaeus, 1758) = veliki zeleni konjic
First faunistic record for Croatia: Frauenfeld 1861
Distribution in Croatia: Widely distributed, common in all regions.
Distribution Europe: Widespread in the entire continent, from Portugal in the west and Southern Finland in the north, to Southern Spain and Mediterranean islands (Lampedusa, Crete and Cyprus) in the south and Eastern European Russia in the east (Hochkirch et al. 2016).
description: Published as part of Skejo, Josip, Rebrina, Fran, Szövényi, Gergely, Puskás, Gellért & Tvrtković, Nikola, 2018, The first annotated checklist of Croatian crickets and grasshoppers (Orthoptera: Ensifera, Caelifera), pp. 1-95 in Zootaxa 4533 (1) on page 36, DOI: 10.11646/zootaxa.4533.1.1, http://zenodo.org/record/2615747
In-Cabin Particulate Matter Quantification and Reduction Strategies - Final Report
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection (NJDEP)
Year: 2009

description: This study evaluated the actual contributions from both the crankcase and the tailpipe emissions to in-cabin levels of fine and ultrafine particulate matter, and determined the effectiveness of commercially available retrofit technologies towards reducing levels of particulate matter inside the school bus passenger compartment. Previous studies have reported elevated concentrations of diesel particulate matter inside the cabin of the school bus. The elevated particulate concentrations have been attributed to the self-pollution from the school bus tailpipe and/or crankcase vent. Although there are uncertainties in the source of the particulate matter, the issue has gained national attention because children are a particularly sensitive subpopulation to the adverse health effects from diesel particulate matter. The objectives of this study are to measure the concentrations of fine and ultrafine particles within the cabin of a school bus with and without retrofit technologies.
Novel Links Between Wnt Signaling, Centrosomes, and Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Normal patterns of Wnt signaling are necessary for tissue development and maintenance, while hyperactive Wnt signaling is implicated in many cancers, especially colon cancer. Indeed, loss of the Wnt pathway negative regulator adenomatous polyposis coli (APC) is typically an early step in the progresson of colon cancers. APC loss results in the stabilization of beta-catenin, which then forms active heterodimers with LEF/TCF (lymphoid enhancer factor/T-cell factor) transcription factors. LEF/TCF target genes promote proliferation, migration, Waarburg-type metabolism, and survival, all of which contribute to malignancy. Our preliminary experiments have uncovered intriguing new connections between the Wnt signaling pathway and the centrosome, the major organizer of the microtubule cytoskeleton in mammalian cells. Specifically, we have found that LEF/TCF transcription factors localize to the centrosome, where they interact with the centrosomal scaffold protein CEP152, and with the protein kinase PLK4. Futhermore, our preliminary studies indicate that that PLK4 phosphorylates the TCF1 protein and regulates the expression of LEF/TCF target genes. The centrosome is critical for the maintenance of genome integrity, and the PLK4 protein kinase is the master regulator of centrosome duplication, whose over- or under-expression causes tumor-promoting chromosomal instability. Thus, our findings suggest potential new connections between Wnt signaling and the maintenance of genome stability. We propose a series of experiments to determine the mechanism and functional consequences of the centrosomal localization of LEF/TCF transcription factors, and of the phosphoregulation of LEF/TCF factors by PLK4. We will determine the domain of CEP152 that binds to LEF/TCF transcriptional factors and the functional consequences of this interaction. In addition, we will map the site(s) of PLK4-mediated phosphorylation of TCF transcription factors, and investigate the functional consequence of this phosphorylation The potential impact of the studies proposed herein is considerable. Our research could reveal new therapeutic opportunities for targeting the Wnt pathway, unexpected new connections between Wnt signaling and the maintenance of genome stability, and a novel mechanism by which the centrosome may communicate with the nucleus to regulate gene expression.
Municipal Stormwater Regulation Program, Status Summary Report, 2004-2008
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection, Division of Water Quality
Year: 2009

description: New Jersey Department of Environmental Protection's Municipal Stormwater Regulation Program is designed to address the impacts of stormwater-borne pollution on our State's waterways.  This effort is part of a national program mandated by the US Clean Water Act and the US Environmental Protection Agency.  In 2008 the Department prepared a Status Summary Report that provided information from the inception of the program in 2004.  This report provides updated information through April 2008.
High-throughput analysis of DNA Repair Cancer Variants
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Variants of unknown significance (VUS) in cancer-causing genes are a glaring blind spot in genomic approaches to clinical cancer diagnosis. As more patients and clinicians gain access to both somatic and germline DNA sequencing, the utility of the sequencing information is hampered by the lack of definitive functional assessment of variants in cancer-associated genes such as those in DNA repair genes. Biallelic inherited mutations in the DNA base excision repair (BER) gene MUTYH lead to MUTYH-associated polyposis (MAP), a colorectal cancer syndrome, and less commonly, other forms of cancer. MUTYH prevents G:C to T:A mutations caused by the common base oxidation product, 8-oxoguanine (OG) by removing mis-placed As from OG:A mismatches. Reduced activity of MUTYH leads to somatic mutations in the tumor suppressor APC and the oncogene KRAS. Clinical reporting databases have grown to include over three hundred unique germline MUTYH variants, the vast majority VUS. It is unclear whether the large number of uncharacterized MUTYH variants are silent polymorphisms or deficient in DNA repair. We propose to determine the cancer-causing potential of a large number of MUTYH missense and nonsense variants in human cells using an innovative multi-faceted approach that leverages our previously developed mammalian cell OG:A repair assay, recent advances in creating large saturation mutagenesis libraries of gene expression constructs, CRISPR and recombinase genome engineering approaches, and long-read DNA sequencing technology. Specifically, this project will entail developing methods for generating a large library of MUTYH variants that can be expressed in human cells. Cells will then be transfected with an OG:A fluorescent reporter to determine the extent of MUTYH-mediated repair and then sorted based on repair capacity. Analysis of the MUTYH variant constructs in specific sorted categories coupled with statistical data analysis will provide a quantitative assessment of the OG:A repair capacity (and thus the cancer-causing potential) of the MUTYH variants. The proposed project will entail analysis of a subset of possible MUTYH variants with the idea that once validated, this approach will provide a basis for analysis of all possible variants. Moreover, the approach may be readily adapted for the analysis of other BER cancer-associated variants.
Automeris larra
Creators: name: Bénéluz, Frédéric
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Saturniidae
Automeris
Automeris larra

description: Automeris larra (Walker, 1855)
Hyperchiria larra Walker, 1855: 1293, no. 16.
Automeris carra – Conte 1906: 160.
DÉTERMINATION. — Morphologique. Moléculaire (BOLD:AAC2953).
LOCALITÉ TYPE. — Brésil (Lemaire 1971).
RÉPARTITION GÉOGRAPHIQUE. — Guyano-amazonienne (Lemaire 2002).
PHÉNOLOGIE. — Le créneau horaire durant lequel l’insecte se montre à la lumière est un indicateur spécifique (Lamarre et al. 2015). La phénologie du mâle de A. larra en Guyane est très inhabituelle, avec deux créneaux (19-20 h et 2-4 h) dont le second coïncide avec celui du mâle de Automeris egeus (FB, obs. pers.).
DISTRIBUTION EN GUYANE. — Connu des trois zones biogéographiques.
HABITAT EN GUYANE. — Forêts primaire et secondaire, savane.
description: Published as part of Bénéluz, Frédéric, 2021, Liste commentée des Saturniidae (Lepidoptera, Bombycoidea) de Guyane, avec la liste des taxons récoltés au Mitaraka (extrême sud-ouest guyanais), pp. 759-809 in Zoosystema 43 (31) on page 786, DOI: 10.5252/zoosystema2021v43a31, http://zenodo.org/record/5796817
Targeting Decreased Lysosome pH to Limit Cancer Progression
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cancer cells rely on an altered metabolism to generate biomass to fuel metastasis and rapid cell proliferation. One goal of current cancer research is to therapeutically correct altered metabolism to limit disease progression. Most efforts toward this goal focus on targeting intermediary metabolic pathways, including glycolysis, oxidative phosphorylation, and fatty acid catabolism. Our proposal tests an alternative idea of targeting dysregulated lysosome pH (pHlys) as a strategy to limit biomass production and proliferation. Lysosomes are catabolic hubs and in normal cells pHlys is ~ 5.0 for the activity of lumenal acid-activated proteases. In cancer cells pHlys is thought to be lower compared with normal cells, which we confirmed in breast and pancreatic cancer cells. A lower pHlys increases catabolism of macromolecules to increase biomass. We are applying for CRCC funding to begin testing the feasibility of therapeutically restoring pHlys to normal values to limit tumorigenic behaviors. However, resolving the feasibility of targeting pHlys for cancer therapeutics is currently constrained by two limitations. First, we lack tools to selectively measure pHlys, with current studies relying on phagocytosis of pH-sensitive dyes that accumulate in multiple intracellular compartments. Second, beyond the V-ATPase, which localizes in multiple intracellular compartments, lysosome-specific proteins regulating pHlys remain unknown but could be therapeutic targets. To resolve the first limitation we generated and validated a new genetically encoded pHlys biosensor (pHLARE) that localizes predominantly in lysosomes and was used to confirm that cancer cells of different tissue origins have a pHlys ~ 4.3. To resolve the second limitation we used pHLARE in a genetic screen with CRISPR/Cas9 silencing of lysosome-specific proteins and found that genetic silencing of ClC-7, a Cl-H transporter, significantly increases pHlys and hence could be a feasible therapeutic target. However, to validate feasibility requires confirming our hypothesis that correcting lower pHlys in cancer cells will limit tumorigenic properties. We will test this hypothesis by increasing pHlys in cancer cells with silencing ClC-7 and determine effects on proliferation (Aim 1), invasion (Aim 2), and oncogenic transformation (Aim 3).
Ageniella (Priophanes) erythroptera Banks 1946
Creators: name: Waichert, Cecilia
name: Colombo, Wesley Dondoni
name: Von Dohlen, Carol D.
name: Pitts, James P.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Pompilidae
Ageniella
Ageniella erythroptera

description: Ageniella (Priophanes) erythroptera (Banks, 1946)
Priophanes erythroptera BaNkS, 1946, MUS. COMp. ZOOL. BULL., vOL. 96, p. 443 [HOLOtypE: ♀, BRAZIL, SãO PaULO (CUIC), ExaMINEd].
Distribution. BRaZIL.
Host. UNkNOWN.
Remarks. IT IS pOSSIbLE ThaT ThIS SpEcIES IS a jUNIOR SYNONYm Of Ageniella rufofemorata (TaSchENbERg, 1869) fROm ARgENTINa (PaRaNa, ROSaRIO). WE haVE NOT ExamINEd ThE TYpE Of A. rufofemorata bUT SpEcImENS IdENTIfIEd IN US cOLLEcTIONS. ThE dEScRIpTION Of A. rufofemorata IS pOOR aNd cOULd fIT SEVERaL SpEcIES Of Ageniella, REaSON WhY WE dO NOT SYNONYmIZE ThE BaNkS' SpEcIES.
description: Published as part of Waichert, Cecilia, Colombo, Wesley Dondoni, Von Dohlen, Carol D. & Pitts, James P., 2018, Taxonomic contributions to Ageniella Banks, 1912 (Hymenoptera: Pompilidae) from Brazil, pp. 133-153 in Zootaxa 4403 (1) on page 148, DOI: 10.11646/zootaxa.4403.1.8, http://zenodo.org/record/1212065
Ageniella (Priophanes) nigerrima Fox 1897
Creators: name: Waichert, Cecilia
name: Colombo, Wesley Dondoni
name: Von Dohlen, Carol D.
name: Pitts, James P.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Pompilidae
Ageniella
Ageniella nigerrima

description: Ageniella (Priophanes) nigerrima (Fox, 1897)
(FIgS 10, 11)
Salius (Priocnemis) nigerrimus FOx, 1897, Acad. Nat. ScI. PhILa. PrOc., vOL. 49, p. 271 [HOLOtypE: ♀, BRAZIL, Chapada (CMNH), ExaMINEd].
Distribution. BRaZIL, COLOmbIa (FERNÁNdEZ 2000).
Host. UNkNOWN.
Remarks. ThIS SpEcImEN IS aNOThER SpEcIES fOUNd amONg FOx’S TYpES IN ThE CaRNEgIE COLLEcTION. ThE TYpE had a LabEL “DREIS 1961— Priophanes nigerrima ”.
description: Published as part of Waichert, Cecilia, Colombo, Wesley Dondoni, Von Dohlen, Carol D. & Pitts, James P., 2018, Taxonomic contributions to Ageniella Banks, 1912 (Hymenoptera: Pompilidae) from Brazil, pp. 133-153 in Zootaxa 4403 (1) on page 148, DOI: 10.11646/zootaxa.4403.1.8, http://zenodo.org/record/1212065
Identifying vulnerabilities in drug-resistant cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The emergence of resistance mechanisms in response to targeted chemotherapies remains an incredibly important and unaddressed challenge in cancer treatment. During treatment, a small fraction of cells often evades first-line chemotherapies, resulting in cells in a drug-resistant “persister” state that have the potential to initiate relapse and growth of a drug-resistant tumor. Exciting recent studies discovered that persister cells are sensitive to a regulated form of cell death called ferroptosis. These results raise the possibility that activation of ferroptosis is a viable approach to kill persister cells. Unfortunately, our understanding of the mechanisms of ferroptosis in persister cells remains limited. Moreover, whether there are additional vulnerabilities in persister cells that can be therapeutically exploited remains an open question. We have developed systems-level strategies to uncover mechanisms of cancer cell drug resistance. For example, exploiting a whole genome CRISPR synthetic lethal screen, we recently identified a new protective mechanism involving the oxidoreductase AIFM2 that suppresses lipid peroxidation and promotes ferroptosis resistance in lung cancer cells. These preliminary findings support the utility of our functional genomic platforms to identify new therapeutically relevant targets in lung cancer. Our proposed research exploits our genetic strategies to uncover and drug novel vulnerabilities in cancer persister cells. Our research examines cell death pathways (CSO1.1) and the biology of persister cancer cells (CSO1.4). We will directly examine the hypothesis that AIFM2 protects drug-resistant cancer cells from ferroptosis and we will implement whole genome CRISPR screens to identify novel vulnerabilities in persister cells. Together, these complementary approaches will uncover new mechanisms of drug resistance and will identify therapeutically relevant targets that can be targeted to kill cancer persister cells.
Activating anti-tumor immunity through the phosphatase SHP1
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The protein tyrosine phosphatase SHP1 (gene name Ptpn6) restricts the activation of a number of immune cell types, including neutrophils, macrophages, dendritic cells, B- and T-lymphocytes. SHP1 reverses immune cell activation by dephosphorylating intracellular signaling intermediates in a number of cell activation pathways. Mice with a spontaneous mutation in Ptpn6, which results in loss of SHP1 protein, develop skin and lung inflammation as well as systemic autoimmunity. In humans, mutations in PTPN6 are associated with chronic inflammatory skin diseases. Our laboratory has studied the immune cell types and intracellular signaling pathways regulated by SHP1 in the setting of inflammation and autoimmunity using inducible and conditional gene knockout mice. Since SHP1 limits normal immune responses it may also function to restrict the immune response to cancer. Using our SHP1-deficient mouse models, we are in the position to test the hypothesis that SHP1 also restricts anti-tumor immunity. Study of anti-tumor immunity is a new area for our group; this proposed work will be carried out in collaboration with cancer researchers at UCSF. We propose to challenge mice containing an inducible deletion of SHP1 (Ptpn6flox/floxROSA26-CreERT2) or conditional knockout animals that lack SHP1 in only neutrophils, monocytes/macrophages, dendritic cells or T-cells, with various well-studied syngeneic murine tumor lines (B16 melanoma, MC-38 colon cancer, EO77.1 mammary cancer). We will then monitor tumor growth and tumor immune responses in the wild type versus SHP1-deficient animals. In a single pilot experiment, inducible loss of SHP1 (in Ptpn6flox/floxROSA26-CreERT2 animals treated 6 days before tumor challenge with tamoxifen to cause Ptpn6 deletion) resulted in a significant delay in growth of MC-38 cells. We will also test whether deletion of SHP1 enhances the efficacy of immunotherapies (such as anti-PD1 checkpoint inhibitors or various anti-tumor monoclonal antibodies) directed against these tumors. If successful, this will lead to future studies to determine the mechanisms (the cell types and signaling pathways) by which SHP1 restricts tumor immunity. This work could also identify SHP1 as a new immunotherapeutic target in cancer.
Final Report: Contribution of Particle Emissions from a Cement-Related Facility to Outdoor Dust in Surrounding Community
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection, Division of Science, Research and Technology
Year: 2009

description: A facility that processes steel production slag into material for cement manufacture is located near the neighborhood of Waterfront South (WFS), Camden, New Jersey. The residents in the vicinity of the facility have had concerns about the impact of the fugitive particulate emissions from the material stored and/or used at the facility on the neighborhood as outdoor dust air  pollution. To address their concern, this study collected deposited particles and surface dust samples near the facility and the raw material (RCM) from the pile of the dust outside of the facility, analyzed morphological characteristics and elemental concentrations in the samples, and assessed the contribution of particles emitted from the facility to the dust pollution in local  community.
Zeuneriana amplipennis
Creators: name: Skejo, Josip
name: Rebrina, Fran
name: Szövényi, Gergely
name: Puskás, Gellért
name: Tvrtković, Nikola
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Tettigoniidae
Zeuneriana
Zeuneriana amplipennis

description: 76. Zeuneriana amplipennis (Brunner von Wattenwyl, 1882) = (istočni) močvarni konjic
First faunistic record for Croatia: this study
Distribution in Croatia: A large population of the species was recently found in the Pannonian region, Vrbanja
County (near Strošinci village), close to Jamena, the nearest known locality in Vojvodina, Serbia (Pavićević et al. 2014) (Ivković pers. comm).
Distribution in Europe: Along the lower courses of Sava and Danube rivers, currently known from the Serbian/ Croatian/Bosnian border area (see above), via Serbia (Pavićević et al. 2014) to Romania (Chobanov et al. 2016).
IUCN Red List status: Endangered (Europe), Near Threatened (EU28) (Hochkirch et al. 2016).
Taxonomic note: Taxonomic relationship of Z. amplipennis and Z. marmorata (Fieber, 1853) is unclear: populations east of Croatia are named Z. amplipennis and west of Croatia Z. marmorata. The latter could simply be a relict westermost population of the same species, expected to be found on other similar localities along the Sava River.
description: Published as part of Skejo, Josip, Rebrina, Fran, Szövényi, Gergely, Puskás, Gellért & Tvrtković, Nikola, 2018, The first annotated checklist of Croatian crickets and grasshoppers (Orthoptera: Ensifera, Caelifera), pp. 1-95 in Zootaxa 4533 (1) on pages 36-37, DOI: 10.11646/zootaxa.4533.1.1, http://zenodo.org/record/2615747
Automeris amoena
Creators: name: Bénéluz, Frédéric
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Saturniidae
Automeris
Automeris amoena

description: Automeris amoena (Boisduval, 1875).
Io amaena [sic] Boisduval, 1875: 216, no. 15.
Automeris amoena – Conte 1906: 167.
DÉTERMINATION. — Morphologique.Moléculaire (BOLD:AAC5754, ACF2288).
LOCALITÉ TYPE. — Guyane (Lemaire 1971).
RÉPARTITION GÉOGRAPHIQUE. — Principalement guyano-amazonienne (Lemaire 2002).
DISTRIBUTION EN GUYANE. — Connu des trois zones biogéographiques.
HABITAT EN GUYANE. — Forêt primaire et savane.
MATÉRIEL DU MITARAKA EXAMINÉ. — Guyane • Spécimen barcodé EL2114 (BOLD: AAC5754); Maripasoula, Mitaraka, Crique Alama (DZ); alt. 310 m; 2°14’1.9”N, 54°27’38.1”W; La Planète revisitée, MNHN / PNI Guyane; APA-973-1; 23.II-26.III.2015; E. Poirier leg.; MNHN • 1 ♂; mêmes données que précédent; MNHN • 2♂; mêmes données que précédent; Coll. FB.
description: Published as part of Bénéluz, Frédéric, 2021, Liste commentée des Saturniidae (Lepidoptera, Bombycoidea) de Guyane, avec la liste des taxons récoltés au Mitaraka (extrême sud-ouest guyanais), pp. 759-809 in Zoosystema 43 (31) on page 786, DOI: 10.5252/zoosystema2021v43a31, http://zenodo.org/record/5796817
Pinelands Biodiversity Study
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection,Division of Science, Research and Technology
Year: 2008

description: The authors undertook this study to assess the effects of different forest management practices on the plant and avian biodiversity in the New Jersey Pinelands. Many plant and animal communities in the Pinelands are globally rare. One consequence of this rarity is that little research has been conducted to document how these communities respond to forestry activities, and yet forestry activities are commonly carried out in this region. The primary objective of this study was to assess the diversity of birds and plants (vascular) in stands with and without historic forestry activities.
A Guide to the Hexavalent Chromium in Household Dust Studies
Creators: name: No Name Supplied
Publisher: name: Chromium Workgroup, Division of Science, Research and Technology, New Jersey Department of Environmental Protection (NJDEP)
Year: 2009

description: This document prepared by The New Jersey Department of Environmental Protection (NJDEP) explains in plain language the results and purpose of the Hexavalent Chromium in Household Dust Studies.
Final Report: Characterization of Hexavalent Chromium Concentrations in Household Dust in Background Areas
Creators: name: No Name Supplied
Publisher: name: Chromium Workgroup, Division of Science, Research, and Technology, New Jersey Department of Environmental Protection
Year: 2009

description: The current study was originally designed as an adjunct to the HCC study (Hudson County/Jersey City Chromium project, NJDEP study SR-06-027) in Jersey City, Hudson County, New Jersey to characterize hexavalent chromium [Cr(VI)] concentrations in house dust.  It was originally assumed that with the remediation of nearly all COPR sites in Jersey City and, given data from studies in the 1990's showing that following remediation of these sites, total Cr levels in house dust returned to background levels, that little or no Cr(VI) would be found in the house dust. However, Cr(VI) was, in fact, found nearly ubiquitously among the homes samples throughout Jersey City, albeit at low levels. This raised a question of the source of the Cr(VI) that was found in Jersey City homes.
Yersinella raymondi
Creators: name: Skejo, Josip
name: Rebrina, Fran
name: Szövényi, Gergely
name: Puskás, Gellért
name: Tvrtković, Nikola
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Tettigoniidae
Yersinella
Yersinella raymondi

description: 75. Yersinella raymondi (Yersin, 1860) = krhka jersinela
First faunistic record for Croatia: Krauss 1879
Distribution in Croatia: Frequently found along the Adriatic coast, the Dinaric Alps, and on most islands (Cres, Hvar Isl.).
Distribution in Europe: Mediterranean part, from Northeastern Spain to Western Greece, including Corsica, Sardinia and Sicily (Hochkirch et al. 2016).
description: Published as part of Skejo, Josip, Rebrina, Fran, Szövényi, Gergely, Puskás, Gellért & Tvrtković, Nikola, 2018, The first annotated checklist of Croatian crickets and grasshoppers (Orthoptera: Ensifera, Caelifera), pp. 1-95 in Zootaxa 4533 (1) on page 36, DOI: 10.11646/zootaxa.4533.1.1, http://zenodo.org/record/2615747
Role of lncRNA DDRLNC1 in DNA repair
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Our recent genome-wide profiling of Poly(A) RNA in response to DNA damage identified a long non-coding RNA (lncRNA), termed DNA damage response long non-coding RNA 1 (DDRLNC1). Upon DNA damage, DDRLNC1 exhibits 5-fold increase in RNA level and alternative splicing. The Cancer Genome Atlas (TCGA) analysis revealed that DDRLNC1 level was significantly altered in a large number of tumors across many different cancer types. To understand its molecular mechanism of action, we performed RNA pull-down followed by MS analysis and identified XRCC5 (Ku70) and XRCC6 (Ku80) as the top DDRLNC1-associated proteins, supporting its role in double-strand break (DSB) repair by non-homologous end joining (NHEJ). To establish its functional significance, we deleted DDRLNC1 by CRISPR-Cas9 and observe increased level of unrepaired DNA upon DNA damage. Because NHEJ often promotes inaccurate re-ligation of DSB, it is believed to play a role in increasing genomic instability. Importantly, inhibition of NHEJ has been shown to play a critical role in radio-sensitization. Our working hypothesis thus is that, through interacting with Ku70 and Ku80, DDRLNC1 enhances NHEJ, which promotes error-prone DNA repair and reduces therapeutic responsiveness of cancer cells. To test our hypothesis the following two specific aims will be proposed. In Aim 1, we will study how DDRLNC1 regulates NHEJ repair. In Aim 2, we will address whether this regulation contributes to therapeutic responsiveness of cancer cells.
Role of LMO1/MYCN in the initiation of human neuroblastoma
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Neural crest (NC) cells are an embryonic stem cell population that gives rise to multiple derivatives, including neurons and glia of the peripheral nervous system. Aberrant NC development leads to aggressive cancers such as neuroblastoma (NB), which accounts for up to 15% of pediatric cancer-related deaths and is highly metastatic. About 25% of NB expresses high levels of the MYC proto-oncogene, MYCN. More recently, the transcriptional regulator LIM-domain-only 1 (LMO1), has been identified as a NB oncogene, yet the precise mechanism by which it promotes metastatic NB is unknown. We propose to precisely address the molecular mechanisms by which LMO1/MYCN contribute to the initiation of human NB using a novel dual inducible model of human NC cell-derived neuroblastoma. We have developed a rapid and robust model of human embryonic stem cell-derived NC, which closely recapitulates different stages of NC development as reported in animal model systems. These hNC cells have migratory potential and the capacity to differentiate into NC derivatives including peripheral neurons (1 week), glia (3 week) and sympathoadrenal cells (5 days) in an efficient manner. Our transcriptomic analysis of hNC development identified LMO1 and MYCN expression during early stages of NC development, yet their role in NC development is also not known. It is well-established that cancer often arises as the result of reactivating developmental pathways. Therefore, we hypothesize that LMO1/MYCN activation in NB triggers early neural crest behaviors that enables cancer. To determine the role of LMO1/MYCN during formation of NC-derived NB, we propose to use CRISPR/Cas9 genome editing to generate a dual inducible hESC line that overexpresses LMO1/MYCN. This will serve, to the best of our knowledge, as the first system modeling early human NB initiation. We will assess the effects of LMO1/MYCN overexpression in hNC cells differentiated towards the sympathoadrenal fate by assaying for cell proliferation, survival, migration, and formation of neuroblastoma phenotype. Finally, we will address the effects of LMO1/MYCN overexpression on gene expression changes during the formation of NC-derived neuroblastoma using RNA-seq analysis. Our study will unveil the function of LMO1/MYCN in the initiation of human NB, aiding in the identification of novel targets for early detection and therapy.
Clean Ocean Advocate, August 2009
Creators: name: No Name Supplied
Publisher: name: Clean Ocean Action (COA)
Year: 2009

description: The monthly Clean Ocean Advocate newsletter informs citizens about critical ocean pollution issues, important meeting dates, proposed legislation, special events, and other notes of interest. Articles in this issue include: WAVES OF THANKS OCEAN DEFENDERS!; Going Green to Save Big Blue; Seven Simple Ways to Save Swimmers from Sewage; Final Bayshore Dredged Material Management Plan Released; Flipper-Friendly Fun; You Can Help Keep Our Ocean Wild & Industry Free; Atlantic Sea Island Group Withdraws Lawsuit Against NJ; NJ Legislature Environmental Committees Host Shore Hearing; and NJ Assembly Overwhelmingly Votes Against Offshore Drilling.
Clean Ocean Advocate, July 2009
Creators: name: No Name Supplied
Publisher: name: Clean Ocean Action (COA)
Year: 2009

description: The monthly Clean Ocean Advocate newsletter informs citizens about critical ocean pollution issues, important meeting dates, proposed legislation, special events, and other notes of interest. Articles in this issue include: Calling All Friends of the Ocean: CELEBRATE OCEAN INDEPENDENCE DAY Keep Our Ocean Wild & Free from LNG; Fish Advisory Updates, Good News and Bad News; NJ Bathing Beach Rules Undermine Public Health; COA's New Public Advocacy Fellow Onboard; SEA SCENES: Next Generation Launches Fantasy Surfing for Local Waters; Governors Establish Mid-Atlantic Regional Council on the Ocean; Obama Shows Leadership on the Ocean; and Wave Energy Proposal Update.
Clean Ocean Advocate, May 2009
Creators: name: No Name Supplied
Publisher: name: Clean Ocean Action (COA)
Year: 2009

description: The monthly Clean Ocean Advocate newsletter informs citizens about critical ocean pollution issues, important meeting dates, proposed legislation, special events, and other notes of interest. Articles in this issue include: Statewide Record Turnouts for Clean Ocean Action 24th Annual Spring Beach Sweeps; New Regulations Finalized for Offshore Renewables; Clean Coastal Environment and Public Health Act of 2009;   League of Women Voters Forum; COA Releases 2008 Beach Sweep Report; and SEA SCENES: Tildesley Family's Beachy Spirit Inspires Sand Dollar Campaign.
Ageniella (Priophanes) otiosa Banks 1946
Creators: name: Waichert, Cecilia
name: Colombo, Wesley Dondoni
name: Von Dohlen, Carol D.
name: Pitts, James P.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Pompilidae
Ageniella
Ageniella otiosa

description: Ageniella (Priophanes) otiosa (Banks, 1946)
Priophanes otiosa BaNkS, 1946, MUS. COMp. ZOOL. BULL., vOL. 96, p. 442 [HOLOtypE: ♀, BOLIVIA, SaNta CrUz (MCZ #26641), ExaMINEd]. JUNIOr SyNONyM Of Ageniella longula (CrESSON) accOrdINg tO TOWNES 1957: 175. WE rEINStatE hErE thE NaME aNd SpEcIfIc StatUS Of Ageniella otiosa (BaNkS), stat. resurr.
Distribution. BOLIVIa, BRaZIL (NEW REcORd).
Examined material. BRAZIL: RIO GRaNdE dO SUL, 2 ♀, MORRO REdONdO, 31°40’22’’S 52°35’30’’W, 101 m, MaLaISE, 5.III.2004, R. F. KRügER cOLL. (UFES); CapãO dO LEãO, 31°48’16’’S 52°35’30’’W, 7m, MaLaISE, R.F. KügER cOLL., 1 ♀ 7.II.2003, 1 ♀ 19.II.2004 (UFES).
Host. UNkNOWN.
Remarks. TOWNES (1957) SYNONYmIZEd Priophanes otiosa BaNkS WITh Ageniella (Nemagenia) longula (CRESSON). ThE hOLOTYpE Of A. longula IS a maLE SpEcImEN WhILE A. otiosa IS REpRESENTEd bY a fEmaLE hOLOTYpE. DESpITE ThE SExUaL dImORphISm ExpEcTEd, WE ExamINEd bOTh TYpES aNd REINSTaTE ThE NamE Ageniella otiosa baSEd ON ThE dIffERENcES ObSERVEd: A. otiosa haS cUpRUm SETaE cOVERINg ThE VERTEx, pOSTERIOR maRgIN Of pRONOTUm, aNd mESOScUTUm, WhIch aRE abSENT IN A. longula; ThE pRONOTUm IS NOT aS LONg aS SEEm IN A. longula; ThE SpINES IN ThE mId aNd hINd TIbIaS IN fEmaLE SpEcImENS aRE LaRgER aNd mORE cONSpIcUOUS IN A. otiosa ThaN IN A. longula; ThE fOREWINg haS ThE VEIN 2TCU2 STRaIghT, ShapINg cELL 3RS SOmEWhaT TRapEZOIdaL WhEREaS A. longula haS ThE VEIN 2TCU2 cURVEd WITh 3RS cELL ROUNdEd; aNd ThE LaST ThREE mETaSOmaL SEgmENTS aRE bLack (aNd fOURTh TERgITE). MOREOVER, ThE cLYpEUS IS LaRgE aNd TRapEZOIdaL IN A. longula WhEREaS IT IS SLIghTLY aRchEd aNd ROUNdEd IN A. otiosa. ThIS SpEcIES IS mORphOLOgIcaLLY SImILaR TO A. arcuata (BaNkS), dIffERINg bY LackINg ThE abUNdaNT ShORT-WhITE pUbEScENcE ON ThE INTEgUmENT pRESENT ON A. arcuata. ThE WINgS aRE daRkER IN A. otiosa ThaN IN A. arcuata. FINaLLY, A. arcuata dISTRIbUTION IS LImITEd TO ThE NEaRcTIc REgION.
description: Published as part of Waichert, Cecilia, Colombo, Wesley Dondoni, Von Dohlen, Carol D. & Pitts, James P., 2018, Taxonomic contributions to Ageniella Banks, 1912 (Hymenoptera: Pompilidae) from Brazil, pp. 133-153 in Zootaxa 4403 (1) on page 148, DOI: 10.11646/zootaxa.4403.1.8, http://zenodo.org/record/1212065
State Implementation Plan Revision for the Attainment and Maintenance of the 1-Hour Ozone National Ambient Air Quality Standard: Update to Meeting the Requirements of the Alternative Ozone Attainment Demonstration Policy
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection (NJDEP), Bureau of Air Quality Planning
Year: 2001

description: This revision to the New Jersey State Implementation Plan (SIP) for the Attainment and Maintenance of the Ozone National Ambient Air Quality Standards (NAAQS) provides for fulfillment of an enforceable commitment by New Jersey to adopt sufficient measures to address required additional emission reductions identified by the United States Environmental Protection Agency (USEPA).1 In addition, this SIP revision contains: New Jersey's Reasonably Available Control Measures (RACM) Analysis and results2, and the USEPA Mid-Course Review.
Automeris moresca Schaus 1906
Creators: name: Bénéluz, Frédéric
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Saturniidae
Automeris
Automeris moresca

description: Automeris moresca Schaus, 1906.
Automeris moresca Schaus, 1906: 90.
DÉTERMINATION. — Morphologique.Moléculaire (BOLD:AAB0971, AAC2436).
LOCALITÉ TYPE. — Guyane (Schaus 1906).
RÉPARTITION GÉOGRAPHIQUE. — Guyano-amazonienne (Lemaire 2002).
DISTRIBUTION EN GUYANE. — Connu des trois zones biogéographiques.
HABITAT EN GUYANE. — Forêt primaire et savane.
MATÉRIEL DU MITARAKA EXAMINÉ. — Guyane • 1 ♀; Maripasoula, Mitaraka,Crique Alama (DZ); alt. 310 m; 2°14’1.9”N, 54°27’38.1”W; La Planète revisitée, MNHN / PNI Guyane; APA-973-1; 23.II-26. III.2015; E. Poirier leg.; Coll. FB.
description: Published as part of Bénéluz, Frédéric, 2021, Liste commentée des Saturniidae (Lepidoptera, Bombycoidea) de Guyane, avec la liste des taxons récoltés au Mitaraka (extrême sud-ouest guyanais), pp. 759-809 in Zoosystema 43 (31) on page 786, DOI: 10.5252/zoosystema2021v43a31, http://zenodo.org/record/5796817
Arachnocephalus vestitus Costa 1855
Creators: name: Skejo, Josip
name: Rebrina, Fran
name: Szövényi, Gergely
name: Puskás, Gellért
name: Tvrtković, Nikola
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Gryllidae
Arachnocephalus
Arachnocephalus vestitus

description: 77. Arachnocephalus vestitus Costa, 1855 = ljuskavi šturak grmušar (Fig. 6B)
First faunistic record for Croatia: Brunner von Wattenwyl 1882
Also reported as: A. dalmatinus Saussure, 1877 (Saussure 1877)
Distribution in Croatia: Recorded in the coastal area (including southern slopes of the Dinaric Alps) and on numerous Adriatic islands. Most likely common but overlooked.
Distribution in Europe: Southern part of the continent, from Southern France, northern Italy and Slovenia in the north, to Portugal and Mediterranean islands (Lampedusa, Sicily, Crete, Cyprus) in the south, and Southeastern Ukraine in the east (Hochkirch et al. 2016).
description: Published as part of Skejo, Josip, Rebrina, Fran, Szövényi, Gergely, Puskás, Gellért & Tvrtković, Nikola, 2018, The first annotated checklist of Croatian crickets and grasshoppers (Orthoptera: Ensifera, Caelifera), pp. 1-95 in Zootaxa 4533 (1) on page 37, DOI: 10.11646/zootaxa.4533.1.1, http://zenodo.org/record/2615747
Mogoplistes brunneus Serville 1838
Creators: name: Skejo, Josip
name: Rebrina, Fran
name: Szövényi, Gergely
name: Puskás, Gellért
name: Tvrtković, Nikola
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Mogoplistidae
Mogoplistes
Mogoplistes brunneus

description: 78. Mogoplistes brunneus Serville, 1838 = tamni ljuskavi šturak
First faunistic record for Croatia: Krauss 1879
Distribution in Croatia: Rather widespread and common along the Adriatic coast with islands (Hvar, Mljet, Šipan) and the southern slopes of the Dinaric Alps.
Distribution in Europe: Widespread in the Mediterranean, from Northeastern Spain in the west and Southern France and Slovenia in the north, to Sicily in the south and Greece in the east (Hochkirch et al. 2016).
description: Published as part of Skejo, Josip, Rebrina, Fran, Szövényi, Gergely, Puskás, Gellért & Tvrtković, Nikola, 2018, The first annotated checklist of Croatian crickets and grasshoppers (Orthoptera: Ensifera, Caelifera), pp. 1-95 in Zootaxa 4533 (1) on page 37, DOI: 10.11646/zootaxa.4533.1.1, http://zenodo.org/record/2615747
Enhanced Inspection and Maintenance (I/M) Program for the State of New Jersey, Revised Performance Standard Modeling
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection (NJDEP), Bureau of Air Quality Planning
Year: 2002

description: This document is a revision to the State of New Jersey's enhanced inspection and maintenance (I/M) program State Implementation Plan (SIP). Specifically, this document provides the United States Environmental Protection Agency (USEPA) with a revision to New Jersey's enhanced I/M performance standard modeling. The primary reason for this revised performance standard modeling is to satisfy the USEPA's requirements for securing their approval for the State to extend the new vehicle emission inspection exemption from the current one inspection cycle (i.e., 2 years) to two inspection cycles (i.e., 4 years). Governor James E. McGreevey enacted this new car emission inspection exemption on July 1, 2002, however, implementation of this exemption is contingent on USEPA approval. In addition, this revised performance standard modeling takes into account several proposed changes to the I/M program that, if adopted, will impact the overall effectiveness of the program.
Ageniella (Priophanes) pallicornis Banks 1946
Creators: name: Waichert, Cecilia
name: Colombo, Wesley Dondoni
name: Von Dohlen, Carol D.
name: Pitts, James P.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Pompilidae
Ageniella
Ageniella pallicornis

description: Ageniella (Priophanes) pallicornis (Banks, 1946)
Priophanes pallicornis BaNkS, 1946, MUS. COMp. ZOOL. BULL., vOL. 96, p. 445 [HOLOtypE: ♀, BRAZIL, SãO PaULO (CUIC), ExaMINEd].
Distribution. BRaZIL.
Host. UNkNOWN.
Remarks. ThIS SpEcIES IS mORphOLOgIcaLLY RELaTEd TO maNY OThER SpEcIES ThaT OccUR IN BRaZIL SUch aS A. dolorosa (BaNkS). ThEY aLL haVE ThE INTEgUmENT bLack WITh bLUISh mETaLLIc REfLEcTIONS. ThE fOREWINg, hOWEVER, IS ThE maIN dISTINcTION. Ageniella pallicornis haS TWO daRk baNdS; ThE fIRST baNd paRTIaLLY cOVERS VEINS R, 1CU, 2CU, aNd 1M, ThE OThER paRTIaLLY cOVERS cELLS 2R1, 1RS, 2M aNd 1M, aNd fULLY cOVERS 2RS; WhEREaS A. dolorosa haS hYaLINE WINg WITh a daRk SpOT ON 2RS aNd 2M. MOREOVER, A. pallicornis haS paLE bROWN fORE aNd hINd LEgS, dIffERINg fROm A. rufitarsis (FIgS. 11, 12) ThaT haS ThE fIRST SEVEN aNTENNaL SEgmENTS aNd aLL TaRSI ORaNgE-RUfOUS.
description: Published as part of Waichert, Cecilia, Colombo, Wesley Dondoni, Von Dohlen, Carol D. & Pitts, James P., 2018, Taxonomic contributions to Ageniella Banks, 1912 (Hymenoptera: Pompilidae) from Brazil, pp. 133-153 in Zootaxa 4403 (1) on page 149, DOI: 10.11646/zootaxa.4403.1.8, http://zenodo.org/record/1212065
State Implementation Plan (SIP) Revision for the Attainment and Maintenance of the Ozone National Ambient Air Quality Standard - New Jersey Revised Motor Vehicle Emission Inventories and Transportation Conformity Budgets Using the MOBILE6 Model
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection (NJDEP), Bureau of Air Quality Planning
Year: 2003

description: This document is a revision to the State of New Jersey's State Implementation Plan for the attainment and maintenance of the one-hour ozone National Ambient Air Quality Standard (NAAQS).  Specifically, this SIP fulfils a commitment made by New Jersey in its April 26, 2000 Attainment Demonstration, to revise its 2005 and 2007 on-road motor vehicle emission budgets for the New Jersey portion of the Philadelphia/Wilmington/Trenton and New Jersey portion of the Northern New Jersey/New York City/Long Island nonattainment areas within one year of the issuance of the MOBILE6 model.  The MOBILE model is a USEPA-developed computer program that estimates ozone precursor emission factors for gasoline-fueled and diesel-powered highway motor vehicles.
Final State Implementation Plan (SIP) Revision for the Attainment and Maintenance of the Carbon Monoxide and One-Hour Ozone National Ambient Air Quality Standards
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection (NJDEP), Bureau of Air Quality Planning
Year: 2004

description: This document establishes updated transportation conformity budgets for New Jersey's Metropolitan Planning Organizations (MPOs) because of changes to emission prediction models. The transportation conformity budgets for carbon monoxide need to be updated because of the change in the United States Environmental Protection Agency's (USEPA) emission factor prediction model from MOBILE5 to MOBILE6. The transportation conformity budgets for the ozone precursors, volatile organic compounds and oxides of nitrogen, need to be updated because of an update to the vehicle registration data used in the emission prediction models. This State Implementation Plan (SIP) revision does not affect any of the planned or implemented control measures for carbon monoxide or the ozone precursors. In addition, this SIP revision does not change the conclusions of the current maintenance plans for carbon monoxide or the attainment plans for ozone. This SIP revision is necessary to enable the MPO's to meet their requirements under the Federal transportation conformity rule.