cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Employment as HIV Prevention: An Employment Support Intervention for Adolescent Men Who Have Sex With Men and Adolescent Transgender Women of Color
Creators: name: Reisner, Sari
name: Kuhns, Lisa
name: Kipke, Michele
name: VandeVusse, Alicia
name: Pashka, Nicole
name: Strader, Lisa C.
name: Slye, Nicole
name: Razzano, Lisa
name: Garofalo, Robert
name: Rosentel, Kris
name: Hill, Brandon J.
name: Williams, Meghan
name: Goolsby, Rachel W.
name: Fuller, Charlie
name: Motley, Darnell N.
name: DeMonte, Justin B.
name: Rupp, Betty M.
name: Bowers, Shannon M.E.
name: Schneider, John A.
Publisher: name: Wolters Kluwer
Year: 2022

description: BACKGROUND: The purpose of this study was to adapt and pilot-test an employment support, primary HIV intervention tailored to the needs of adolescent men who have sex with men and adolescent transgender women of color. SETTING: The intervention was implemented in 2 settings: controlled environment (Phase 1) and real-world community-based (Phase 2) setting in Chicago, IL. METHODS: Eighty-seven adolescent men who have sex with men and adolescent transgender women of color ages 16-24 participated in Work2Prevent , a 4-session employment and HIV prevention intervention, designed to increase job-readiness and reduce HIV risk. Intervention sessions consisted of group activities: educational games, roleplaying/modeling behavior, and self-regulation exercises. Participants were assessed at baseline, postintervention, and 8-month (Phase 1) or 3-month follow-up (Phase 2). RESULTS: Participants evaluated Work2Prevent as feasible and acceptable, rating intervention quality, usefulness, and satisfaction highly. Overall, 59.6% (Phase 1) and 85.0% (Phase 2) participants attended 2 or more sessions. At 8 months, Phase 1 participants reported a mean increase of 11.4 hours worked per week. Phase 2 participants reported a mean increase of 5.2 hours worked per week and an increase in job-seeking self-efficacy. Phase 2 participants also reported a decrease in transactional sex work. CONCLUSION: Work2Prevent is one of the first structural primary HIV interventions to specifically focus on adolescent employment readiness. Findings suggest Work2Prevent is feasible and acceptable, improved adolescent employment outcomes, and reduced HIV risk associated with transactional sex work. Our study underscores the need for alternative pathways, such as addressing socioeconomic determinants, to prevent adolescent HIV infection.
Supplemental Material, Appendix_3_PsA_Search_Strategies - 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis
Creators: name: Singh, Jasvinder A.
name: Guyatt, Gordon
name: Ogdie, Alexis
name: Gladman, Dafna D.
name: Deal, Chad
name: Deodhar, Atul
name: Dubreuil, Maureen
name: Dunham, Jonathan
name: M. Elaine Husni
name: Kenny, Sarah
name: Kwan-Morley, Jennifer
name: Lin, Janice
name: Marchetta, Paula
name: Mease, Philip J.
name: Merola, Joseph F.
name: Miner, Julie
name: Ritchlin, Christopher T.
name: Siaton, Bernadette
name: Smith, Benjamin J.
name: Voorhees, Abby S. Van
name: Jonsson, Anna Helena
name: Shah, Amit Aakash
name: Sullivan, Nancy
name: Turgunbaev, Marat
name: Coates, Laura C.
name: Gottlieb, Alice
name: Magrey, Marina
name: W. Benjamin Nowell
name: Ana-Maria Orbai
name: Soumya M. Reddy
name: Scher, Jose U.
name: Siegel, Evan
name: Siegel, Michael
name: Walsh, Jessica A.
name: Turner, Amy S.
name: Reston, James
Publisher: name: SAGE Journals
Year: 2018
Subjects: Medicine

description: Supplemental Material, Appendix_3_PsA_Search_Strategies for 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis by Jasvinder A. Singh, Gordon Guyatt, Alexis Ogdie, Dafna D. Gladman, Chad Deal, Atul Deodhar, Maureen Dubreuil, Jonathan Dunham, M. Elaine Husni, Sarah Kenny, Jennifer Kwan-Morley, Janice Lin, Paula Marchetta, Philip J. Mease, Joseph F. Merola, Julie Miner, Christopher T. Ritchlin, Bernadette Siaton, Benjamin J. Smith, Abby S. Van Voorhees, Anna Helena Jonsson, Amit Aakash Shah, Nancy Sullivan, Marat Turgunbaev, Laura C. Coates, Alice Gottlieb, Marina Magrey, W. Benjamin Nowell, Ana-Maria Orbai, Soumya M. Reddy, Jose U. Scher, Evan Siegel, Michael Siegel, Jessica A. Walsh, Amy S. Turner, and James Reston in Journal of Psoriasis and Psoriatic Arthritis
Studies towards optimisation of the Analog Hadronic Calorimeter for future linear collider detectors
Creators: name: Tran, Huong Lan
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2016

description: Deutsche Physikalische Gesellschaft - Hamburg 2016, Hamburg, Germany, 29 Feb 2016 - 4 Mar 2016 ; (2016).
description: The Analog Hadronic Calorimeter (AHCAL) is a highly granular calorimeter developed in the CALICE collaboration for future linear collider detectors. Its design concept is based on 3×3 𝑐𝑚2 scintillator tiles readout by Silicon Photomultipliers (SiPM). With this design the ambitious required jet energy resolution of 3-4 % can be achieved using the Pandora Particle Flow Algorithm (PandoraPFA). Recent discussions concerning the overall size and cost of the ILD detector has triggered new studies to optimise AHCAL cell size. A smaller number of cells can reduce the detector cost but the corresponding larger cell size can lead to a degradation of the jet energy resolution. The AHCAL optimisation study therefore has to achieve the best balance between physics performance and cost. Recent studies using the latest version of PandoraPFA with improved pattern recognition have shown significant improvement of jet energy resolution. Moreover, a better energy reconstruction of single particles, in which software compensation plays an important role, can lead to further improvements. This talk will discuss the software compensation technique and its impact on the final cell size optimisation.
Engagement in mHealth behavioral interventions for HIV prevention and care: making sense of the metrics
Creators: name: Bauermeister, Jose A
name: Hightow-Weidman, Lisa B
Publisher: name: AME Publishing Company
Year: 2020

description: BACKGROUND: Engagement is the primary metric by which researchers can assess whether participants in a mHealth intervention used and interacted with the intervention's content as intended over a pre-specified period to result in behavior change. Paradata, defined as the process data documenting users' access, participation, and navigation through a mHealth intervention, have been associated with differential treatment outcomes in mHealth interventions. Within behavioral mHealth interventions, there has been an increase in the number of studies addressing the HIV prevention and care continuum in recent years, yet few have presented engagement metrics or examined how these data could inform design modifications, promote continued engagement, and supplement primary intervention efficacy and scale-up efforts. METHODS: We review common paradata metrics in mHealth interventions (e.g., amount, frequency, duration and depth of use), using case studies from four technology-driven HIV interventions to illustrate their utility in evaluating mHealth behavioral interventions for HIV prevention and care. Across the four case studies, participants' ages ranged between 15 and 30 years and included a racially and ethnically diverse sample of youth. The four case studies had different approaches for engaging young men who have sex with men: a tailored brief intervention, an interactive modular program, a daily tool to monitor and self-regulate treatment adherence, and an online platform promoting social engagement and social support. Each focused on key outcomes across the HIV prevention and care continuum [e.g., safer sex behaviors, HIV testing, antiretroviral therapy (ART) adherence] and collected paradata metrics systematically. RESULTS: Across the four interventions, paradata was utilized to identify patterns of use, create user profiles, and determine a minimum engagement threshold for future randomized trials based on initial pilot trial data. Evidence of treatment differences based on paradata analyses were also observed in between-arm and within-arm analyses, indicating that intervention exposure and dosage might influence the strength of the observed intervention effects. Paradata reflecting participants' engagement with intervention content was used to suggest modifications to intervention design and navigation, to understand what theoretically-driven content participants chose to engage with in an intervention, and to illustrate how engagement was linked to HIV-related outcomes. CONCLUSIONS: Paradata monitoring and reporting can enhance the rigor of mHealth trials. Metrics of engagement must be systematically collected, analyzed and interpreted to meaningfully understand a mHealth intervention's efficacy. Future mHealth trials should work to identify suitable engagement metrics during intervention development, ensure their collection throughout the trial, and evaluate their impact on trial outcomes.
Engaging youth in mHealth: what works and how can we be sure?
Creators: name: Scott, Hyman
name: Hill-Rorie, Jonathan
name: Hightow-Weidman, Lisa B
name: Bauermeister, Jose A
name: Horvath, Keith J
Publisher: name: AME Publishing Company
Year: 2021

description: BACKGROUND: Youth participating in mobile health (mHealth) intervention trials often engage with the technologies [e.g., applications (app) or mobile-optimized websites] only partially, often prematurely discontinuing use altogether. Limited engagement can impact the interventions effect on behavior change and compromise researchers' ability to test and estimate the true efficacy of their interventions. While mHealth interventions have been shown to be feasible and acceptable to youth, across diverse health conditions, strategies to increase engagement have been less well studied. Specifically, within HIV prevention and care mHealth interventions, there is not consensus as to which components represent the "key ingredients" to support maximal engagement of youth. Further, successful intervention evaluation requires the ability to systematically track users' engagement with intervention components (i.e., paradata) to evaluate its effects on behavior change. METHODS: As part of the Adolescent Medicine Trials Network UNC/Emory Center for Innovative Technology (iTech) portfolio of HIV/AIDS Interventions, we present diverse strategies used across five mHealth protocols seeking to promote youth engagement, track and measure engagement through paradata, and incorporate these components into mHealth intervention evaluations. RESULTS: We describe the importance of defining and measuring engagement using case studies from iTech to illustrate how different research teams select mHealth features to promote youth engagement over time, taking into account features embedded in the technology design, key mechanisms of change and trial outcomes (e.g., HIV testing, pre-exposure prophylaxis uptake and adherence, HIV treatment adherence). Finally, we discuss how the research teams plan to evaluate engagement's role on their intervention's outcomes. CONCLUSIONS: Based on this synthesis, we discuss strategies to enhance mHealth engagement during intervention development and design, ensure its monitoring and reporting throughout the trial, and evaluate its impact on trial outcomes.
Safety and immunogenicity of a 15-valent pneumococcal conjugate vaccine in Japanese healthy infants: A Phase I study (V114-028)
Creators: name: Ishihara, Yasunori
name: Kuroki, Haruo
name: Hidaka, Hidenobu
name: Iwai, Kazuyuki
name: Wan, Keiko
name: Shirakawa, Masayoshi
name: Sawata, Miyuki
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: This Phase I study evaluated the safety, tolerability, and immunogenicity of V114, a 15-valent pneumococcal conjugate vaccine (PCV), via subcutaneous (SC) or intramuscular (IM) administration, in healthy Japanese infants 3 months of age. A total of 133 participants were randomized to receive four doses (3 + 1 regimen) of V114-SC (n = 44), V114-IM (n = 45), or 13-valent PCV (PCV13)-SC (n = 44) at 3, 4, 5, and 12–15 months of age. Diphtheria, tetanus, and pertussis–inactivated poliovirus (DTaP–IPV) vaccine was administered concomitantly at all vaccination visits. The primary objective was to assess the safety and tolerability of V114-SC and V114-IM. Secondary objectives were to assess the immunogenicity of PCV and DTaP–IPV at 1-month post-dose 3 (PD3). On days 1–14 following each vaccination, the proportions of participants with systemic adverse events (AEs) were comparable across interventions, whereas injection-site AEs were higher with V114-SC (100.0%) and PCV13-SC (100.0%) than with V114-IM (88.9%). Most AEs were mild or moderate in severity and no vaccine-related serious AEs or deaths were reported. Serotype-specific immunoglobulin G (IgG) response rates at 1-month PD3 were comparable across groups for most shared serotypes between V114 and PCV13. For additional V114 serotypes 22F and 33F, IgG response rates were higher with V114-SC and V114-IM than with PCV13-SC. DTaP–IPV antibody response rates at 1-month PD3 for V114-SC and V114-IM were comparable with PCV13-SC. Findings suggest that vaccination with V114-SC or V114-IM in healthy Japanese infants is generally well tolerated and immunogenic.
Epidemiology of Hip Osteoarthritis: The Johnston County Osteoarthritis Project
Creators: name: Nelson, Amanda
Publisher: name: SAGE Publications
Year: 2023

description: Hip osteoarthritis (OA) is common but understudied compared with knee OA, and insights into the impact of this condition on the general population are needed. This review article summarizes findings from the 30-year, longitudinal, population-based Johnston County Osteoarthritis Project cohort to address the prevalence, incidence, and progression of hip OA and differences by sex and race; similarities and differences related to other joints; and impact on morbidity and mortality.
Evaluations of Prevention Programs for Sexual, Dating, and Intimate Partner Violence for Boys and Men: A Systematic Review
Creators: name: Martin, Sandra L.
name: Young, Belinda-Rose
name: Macy, Rebecca J.
name: Moracco, Kathryn E.
name: Graham, Laurie M.
name: Embry, Venita
name: Reyes, Heather Luz McNaughton
Publisher: name: SAGE Publications
Year: 2019

description: Among violence prevention educators and researchers, there is growing interest in sexual, dating, and intimate partner violence (SV/DV/IPV) prevention programs for males because of evidence showing that boys and men are more likely than girls and women to perpetrate SV as well as more severe forms of DV/IPV. To date, comprehensive guidance on the content, structure, delivery, and effectiveness of such programs is limited. We reviewed randomized controlled studies that evaluated SV/DV/IPV perpetration prevention programs for boys and men. Searches yielded 5,249 potential documents for review of which 10 met inclusion criteria-representing 9 unique studies of 7 distinct programs. Two reviewers independently reviewed and abstracted data from these studies regarding program setting and target audience; type of violence addressed; number and length of program sessions; program duration, topics, activities, and delivery mode; and implementer details. Study characteristics were also examined (sample size, participant characteristics, recruitment, randomization, comparison/control condition, data collection protocols, attrition, measures of violence perpetration, and perpetration findings). The Cochrane Risk of Bias Tool was used to assess study design quality. Results show considerable heterogeneity among program content and delivery strategies, study designs, and outcome measurement. Study sample size ranged widely, and most used cluster-randomized designs, recruited undergraduate college students, and evaluated a multisession program delivered via group sessions. Only one program reduced men's self-reported SV perpetration. Accordingly, critical gaps exist around "what works" for SV/DV/IPV perpetration prevention programs for boys and men.
First Operation of a Harmonic Lasing Self-Seeded Free Electron Laser
Creators: name: Schneidmiller, Evgeny Alexanrdovich
name: Faatz, Bart
name: Kuhlmann, Marion
name: Roensch-Schulenburg, Juliane
name: Schreiber, Siegfried
name: Tischer, Markus
name: Yurkov, M. V.
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2016

description: (2016).
description: Harmonic lasing is a perspective mode of operation of X-ray FEL user facilities that allows to provide brilliant beams of higher energy photons for user experiments. Another useful application of harmonic lasing is so called Harmonic Lasing Self-Seeded Free Electron Laser (HLSS FEL) that allows to improve spectral brightness of these facilities. In the past, harmonic lasing has been demonstrated in the FEL oscillators in infrared and visible wavelength ranges, but not in high-gain FELs and not at short wavelengths. In this paper we report on the first evidence of the harmonic lasing and the first operation of the HLSS FEL at the soft X-ray FEL user facility FLASH in the wavelength range between 4.5 nm and 15 nm. Spectral brightness was improved in comparison with Self-Amplified Spontaneous emission (SASE) FEL by a factor of six in the exponential gain regime. A better performance of HLSS FEL with respect to SASE FEL in the post-saturation regime with a tapered undulator was observed as well. The first demonstration of harmonic lasing in a high-gain FEL and at short wavelengths paves the way for a variety of applications of this new operation mode in X-ray FELs.
Preclinical immunogenicity of an adenovirus-vectored vaccine for herpes zoster
Creators: name: Ulaszewska, Marta
name: Merelie, Sarah
name: Sebastian, Sarah
name: Lambe, Teresa
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Herpes zoster (HZ) results from waning immunity following childhood infection with varicella zoster virus (VZV) but is preventable by vaccination with recombinant HZ vaccine or live HZ vaccine (two doses or one dose, respectively). Vaccine efficacy declines with age, live HZ vaccine is contraindicated in immunosuppressed individuals, and severe local reactogenicity of recombinant HZ vaccine is seen in up to 20% of older adults, indicating a potential need for new vaccines. Nonreplicating chimpanzee adenovirus (ChAd) vectors combine potent immunogenicity with well-established reactogenicity and safety profiles. We evaluated the cellular and humoral immunogenicity of ChAdOx1 encoding VZV envelope glycoprotein E (ChAdOx1-VZVgE) in mice using IFN-γ ELISpot, flow cytometry with intracellular cytokine staining, and ELISA. In outbred CD-1 mice, one dose of ChAdOx1-VZVgE (1 × 107 infectious units) elicited higher gE-specific T cell responses than two doses of recombinant HZ vaccine (1 µg) or one dose of live HZ vaccine (1.3 × 103 plaque-forming units). Antibody responses were higher with two doses of recombinant HZ vaccine than with two doses of ChAdOx1-VZVgE or one dose of live HZ vaccine. ChAdOx1-VZVgE boosted T cell and antibody responses following live HZ vaccine priming. The frequencies of polyfunctional CD4+ and CD8+ T cells expressing more than one cytokine (IFN-γ, TNF-α and IL-2) were higher with ChAdOx1-VZVgE than with the conventional vaccines. Results were similar in young and aged BALB/c mice. These findings support the clinical development of ChAdOx1-VZVgE for prevention of HZ in adults aged 50 years or over, including those who have already received conventional vaccines.
Executive Dysfunction Early Postnatal Biomarkers among Children Born Extremely Preterm
Creators: name: Fichorova, Raina N.
name: Allred, Elizabeth N.
name: Joseph, Robert M.
name: Leviton, Alan
name: Dammann, Olaf
name: Gerry Taylor, H.
name: O'Shea, T. Michael
Publisher: name: Springer Nature
Year: 2018

description: We evaluated the relationship between blood levels of inflammatory and neurotrophic proteins during the first postnatal month in 692 children born before the 28th week of gestation and executive function limitations among those 10-year olds who had an IQ ≥ 70. The measures of dysfunction were Z-scores≤-1 on the Differential Ability Scales-II working memory (WM) assessment) (N=164), the NEPSY-II (A Developmental NEuroPSYchological Assessment-II) Inhibition-Inhibition assessment) (N=350), the NEPSY-II Inhibition-Switching assessment) (N=345), as well as a Z-score ≤ -1 on all three assessments (identified as the executive dysfunction composite (N=104). Increased risks of the executive dysfunction composite associated with high concentrations of inflammatory proteins (IL-8, TNF-α, and ICAM-1) were modulated by high concentrations of neurotrophic proteins. This pattern of modulation by neurotrophins of increased risk associated with inflammation was also seen for the working memory limitation, but only with high concentrations of IL-8 and TNF-α, and the switching limitation, but only with high concentrations of ICAM-1. We infer that among children born extremely preterm, risks of executive function limitations might be explained by perinatal systemic inflammation in the absence of adequate neurotrophic capability.
Supplemental material for Learning to lead: a review and synthesis of literature examining healthcare managers' use of knowledge
Creators: name: Tate, Kaitlyn
name: Hewko, Sarah
name: McLane, Patrick
name: Baxter, Pamela
name: Perry, Karyn
name: Armijo-Olivo, Susan
name: Estabrooks, Carole
name: Gordon, Deb
name: Cummings, Greta
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified

description: Supplemental Material for Learning to lead: a review and synthesis of literature examining healthcare managers' use of knowledge by Kaitlyn Tate, Sarah Hewko, Patrick McLane, Pamela Baxter, Karyn Perry, Susan Armijo-Olivo, Carole Estabrooks, Deb Gordon and Greta Cummings in Journal of Health Services Research & Policy
The policy and political consequences of the B-Mincome pilot project
Creators: name: García, Leire Rincón
Publisher: name: Humboldt-Universität zu Berlin
Year: 2022
Subjects: subject: Pilot projects
subject: cash transfers
subject: universal basic income
subject: political consequences
subject: welfare reform
subject: 320 Politikwissenschaft (Politik und Regierung)

description: The idea of universal basic income is recieving increasing attention in the political, media and public agendas. This policy proposal constitutes a radical departure from the orthodox welfare rationale of giving to those in need, or attaching conditions to welfare support. Given the permutation that a UBI presents, many pilot projects and field experiments are being carried out globally to test the effects of this novel policy idea. Key questions arise from these developments: are the lessons learned from these experiments being fed back into the policy process? Are the pilot project results guiding and informing policymakers? Overall, can we observe any political effects of such scientific efforts? I address these questions through a qualitative case study analysis of the B-Mincome project. Through an in-depth analysis of this pilot, some of the key factors influencing the (limited) policy and political effects of the pilot project have been identified. The B-Mincome case study shows that the barriers to policy change were in place well before the pilot, and evidently, remained unaltered by it. The political landscape in Barcelona's City Council, its economic powers and institutional context were unchanged by the pilot, and in fact shaped the pilot design, moving it away from the UBI proposal. The B-Mincome experience illustrates the need to accommodate the pilot design to the politics and economics of the experiment, and shows the unintended consequences that such an adaptation of the pilot design may have in relation to its original objectives. In the case of Barcelona, this has meant a move away from a UBI-style pilot design, resulting in very limited effects on the debate or policy design of cash transfers, having a greater policy impact on active polices instead. However, by taking a broader look at Spanish and Catalan politics, our analysis has shown that unexpected factors may end up triggering a debate much more effectively than a pilot project.
Supplementary_Table_2._Highly_confident_validated_CNVS_of_fetus_2 - Origins of Intraindividual Genetic Variation in Human Fetuses
Creators: name: Bazrgar, Masood
name: Gourabi, Hamid
name: Karimpour-Fard, Anis
name: Parnaz Borjian Boroujeni
name: Khadije Anisi
name: Movaghar, Bahar
name: Valojerdi, Mojtaba Rezazadeh
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Supplementary_Table_2._Highly_confident_validated_CNVS_of_fetus_2 for Origins of Intraindividual Genetic Variation in Human Fetuses by Masood Bazrgar, Hamid Gourabi, Anis Karimpour-Fard, Parnaz Borjian Boroujeni, Khadije Anisi, Bahar Movaghar, and Mojtaba Rezazadeh Valojerdi in Reproductive Sciences
Evidence for the placenta-brain axis: multi-omic kernel aggregation predicts intellectual and social impairment in children born extremely preterm
Creators: name: Fry, Rebecca C.
name: Santos Jr, Hudson P.
name: Marsit, Carmen J.
name: Smeester, Lisa
name: Bhattacharya, Arjun
name: O'Shea, T. Michael
name: Kuban, Karl C. K.
name: Joseph, Robert M.
Publisher: name: Springer Nature
Year: 2020

description: BackgroundChildren born extremely preterm are at heightened risk for intellectual and social impairment, including Autism Spectrum Disorder (ASD). There is increasing evidence for a key role of the placenta in prenatal developmental programming, suggesting that the placenta may, in part, contribute to origins of neurodevelopmental outcomes.MethodsWe examined associations between placental transcriptomic and epigenomic profiles and assessed their ability to predict intellectual and social impairment at age 10 years in 379 children from the Extremely Low Gestational Age Newborn (ELGAN) cohort. Assessment of intellectual ability (IQ) and social function was completed with the Differential Ability Scales-II and Social Responsiveness Scale (SRS), respectively. Examining IQ and SRS allows for studying ASD risk beyond the diagnostic criteria, as IQ and SRS are continuous measures strongly correlated with ASD. Genome-wide mRNA, CpG methylation and miRNA were assayeds with the Illumina Hiseq 2500, HTG EdgeSeq miRNA Whole Transcriptome Assay, and Illumina EPIC/850 K array, respectively. We conducted genome-wide differential analyses of placental mRNA, miRNA, and CpG methylation data. These molecular features were then integrated for a predictive analysis of IQ and SRS outcomes using kernel aggregation regression. We lastly examined associations between ASD and the multi-omic-predicted component of IQ and SRS.ResultsGenes with important roles in neurodevelopment and placental tissue organization were associated with intellectual and social impairment. Kernel aggregations of placental multi-omics strongly predicted intellectual and social function, explaining approximately 8% and 12% of variance in SRS and IQ scores via cross-validation, respectively. Predicted in-sample SRS and IQ showed significant positive and negative associations with ASD case-control status.LimitationsThe ELGAN cohort comprises children born pre-term, and generalization may be affected by unmeasured confounders associated with low gestational age. We conducted external validation of predictive models, though the sample size (N = 49) and the scope of the available out-sample placental dataset are limited. Further validation of the models is merited.ConclusionsAggregating information from biomarkers within and among molecular data types improves prediction of complex traits like social and intellectual ability in children born extremely preterm, suggesting that traits within the placenta-brain axis may be omnigenic.
Effects of COVID-19 vaccine type on Guillain-Barré syndrome: Two cases and a literature review
Creators: name: Lee, Hsin-Yu
name: Lien, Wan-Ching
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Guillain-Barré syndrome (GBS) is a rare but severe complication of COVID-19 vaccination. We report two cases of GBS following vaccination with the adenovirus vector vaccine ChAdOx1 nCoV-19 (Vaxzevria, AstraZeneca) and review the relevant literature. Relevant studies published between December 2020 and May 2022 including 881 patients with GBS were reviewed. GBS incidence and the need for mechanical ventilation were reported at a higher level among patients receiving Vaxzevria (n = 400). However, incidence cannot be accurately estimated from case reports. Thus, the true GBS rates following COVID-19 vaccination should be determined by population-based data.
Supplemental_Material_2 – Supplemental material for Telementoring of Surgeons: A Systematic Review
Creators: name: Erridge, Simon
name: Yeung, Derek K. T.
name: Hitendra R. H. Patel
name: Purkayastha, Sanjay
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences
subject: 110323 Surgery
subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies
subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, Supplemental_Material_2 for Telementoring of Surgeons: A Systematic Review by Simon Erridge, Derek K. T. Yeung, Hitendra R. H. Patel and Sanjay Purkayastha in Surgical Innovation
CART809401_Supplemental_Material – Supplemental material for Protein Levels and Microstructural Changes in Localized Regions of Early Cartilage Degeneration Compared with Adjacent Intact Cartilage
Creators: name: Bincy Jacob
name: Jüllig, Mia
name: Middleditch, Martin
name: Payne, Leo
name: Broom, Neil
name: Vijayalekshmi Sarojini
name: Ashvin Thambyah
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences
subject: 110323 Surgery
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Supplemental material, CART809401_Supplemental_Material for Protein Levels and Microstructural Changes in Localized Regions of Early Cartilage Degeneration Compared with Adjacent Intact Cartilage by Bincy Jacob, Mia Jüllig, Martin Middleditch, Leo Payne, Neil Broom, Vijayalekshmi Sarojini and Ashvin Thambyah in CARTILAGE
JOP812102_supplemental_material – Supplemental material for Diminished responses to monoaminergic antidepressants but not ketamine in a mouse model for neuropsychiatric lupus
Creators: name: Bettadapura N Srikumar
name: Pattipati S Naidu
name: Narasimharaju Kalidindi
name: Paschapur, Mahesh
name: Bharath Adepu
name: Subramani, Siva
name: Jignesh Nagar
name: Ratika Srivastava
name: Muppana V Sreedhara
name: Durga Shiva Prasad
name: Das, Manish Lal
name: Louis, Justin V
name: Kuchibhotla, Vijaya K
name: Shailesh Dudhgaonkar
name: Pieschl, Rick L
name: Li, Yu-Wen
name: Bristow, Linda J
name: Manjunath Ramarao
name: Reeba K Vikramadithyan
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)

description: Supplemental material, JOP812102_supplemental_material for Diminished responses to monoaminergic antidepressants but not ketamine in a mouse model for neuropsychiatric lupus by Bettadapura N Srikumar, Pattipati S Naidu, Narasimharaju Kalidindi, Mahesh Paschapur, Bharath Adepu, Siva Subramani, Jignesh Nagar, Ratika Srivastava, Muppana V Sreedhara, Durga Shiva Prasad, Manish Lal Das, Justin V Louis, Vijaya K Kuchibhotla, Shailesh Dudhgaonkar, Rick L Pieschl, Yu-Wen Li, Linda J Bristow, Manjunath Ramarao and Reeba K Vikramadithyan in Journal of Psychopharmacology
Supplemental Material, Singh_ART40726_Supplementary_Appendix_2_Panel,_Teams_Involved - 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis
Creators: name: Singh, Jasvinder A.
name: Guyatt, Gordon
name: Ogdie, Alexis
name: Gladman, Dafna D.
name: Deal, Chad
name: Deodhar, Atul
name: Dubreuil, Maureen
name: Dunham, Jonathan
name: M. Elaine Husni
name: Kenny, Sarah
name: Kwan-Morley, Jennifer
name: Lin, Janice
name: Marchetta, Paula
name: Mease, Philip J.
name: Merola, Joseph F.
name: Miner, Julie
name: Ritchlin, Christopher T.
name: Siaton, Bernadette
name: Smith, Benjamin J.
name: Voorhees, Abby S. Van
name: Jonsson, Anna Helena
name: Shah, Amit Aakash
name: Sullivan, Nancy
name: Turgunbaev, Marat
name: Coates, Laura C.
name: Gottlieb, Alice
name: Magrey, Marina
name: W. Benjamin Nowell
name: Ana-Maria Orbai
name: Soumya M. Reddy
name: Scher, Jose U.
name: Siegel, Evan
name: Siegel, Michael
name: Walsh, Jessica A.
name: Turner, Amy S.
name: Reston, James
Publisher: name: SAGE Journals
Year: 2018
Subjects: Medicine

description: Supplemental Material, Singh_ART40726_Supplementary_Appendix_2_Panel,_Teams_Involved for 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis by Jasvinder A. Singh, Gordon Guyatt, Alexis Ogdie, Dafna D. Gladman, Chad Deal, Atul Deodhar, Maureen Dubreuil, Jonathan Dunham, M. Elaine Husni, Sarah Kenny, Jennifer Kwan-Morley, Janice Lin, Paula Marchetta, Philip J. Mease, Joseph F. Merola, Julie Miner, Christopher T. Ritchlin, Bernadette Siaton, Benjamin J. Smith, Abby S. Van Voorhees, Anna Helena Jonsson, Amit Aakash Shah, Nancy Sullivan, Marat Turgunbaev, Laura C. Coates, Alice Gottlieb, Marina Magrey, W. Benjamin Nowell, Ana-Maria Orbai, Soumya M. Reddy, Jose U. Scher, Evan Siegel, Michael Siegel, Jessica A. Walsh, Amy S. Turner, and James Reston in Journal of Psoriasis and Psoriatic Arthritis
SupplementaryMaterial-R2 - Sensitivity to Deviance and to Dissimilarity: Basic Cognitive Processes Under Activation of the Behavioral Immune System
Creators: name: Nussinson, Ravit
name: Mentser, Sari
name: Rosenberg, Nurit
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: Anthropology
subject: FOS: Sociology
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: SupplementaryMaterial-R2 for Sensitivity to Deviance and to Dissimilarity: Basic Cognitive Processes Under Activation of the Behavioral Immune System by Ravit Nussinson, Sari Mentser, and Nurit Rosenberg in Evolutionary Psychology
Evidence that the human cell cycle is a series of uncoupled, memoryless phases
Creators: name: Grant, Gavin D
name: Gupta, Gaorav P
name: Shimerov, Hristo K
name: Limas, Juanita C
name: Fakhreddin, Randy I
name: Kedziora, Katarzyna M
name: Chao, Hui Xiao
name: Perez, Joanna
name: Cook, Jeanette Gowen
name: Kumar, Rashmi J
name: Purvis, Jeremy E
Publisher: name: Springer Nature
Year: 2019

description: The cell cycle is canonically described as a series of four consecutive phases: G1, S, G2, and M. In single cells, the duration of each phase varies, but the quantitative laws that govern phase durations are not well understood. Using time-lapse microscopy, we found that each phase duration follows an Erlang distribution and is statistically independent from other phases. We challenged this observation by perturbing phase durations through oncogene activation, inhibition of DNA synthesis, reduced temperature, and DNA damage. Despite large changes in durations in cell populations, phase durations remained uncoupled in individual cells. These results suggested that the independence of phase durations may arise from a large number of molecular factors that each exerts a minor influence on the rate of cell cycle progression. We tested this model by experimentally forcing phase coupling through inhibition of cyclin-dependent kinase 2 (CDK2) or overexpression of cyclin D. Our work provides an explanation for the historical observation that phase durations are both inherited and independent and suggests how cell cycle progression may be altered in disease states.
A2_Interview_Questions – Supplemental material for Where Are We Going? Where Have We Been?: The Climate for Diversity within Urban Planning Educational Programs
Creators: name: Greenlee, Andrew J.
name: Jackson, April
name: Ivis Garcia-Zambrana
name: C. Aujean Lee
name: Chrisinger, Benjamin
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 120599 Urban and Regional Planning not elsewhere classified
subject: FOS: Social and economic geography

description: Supplemental material, A2_Interview_Questions for Where Are We Going? Where Have We Been?: The Climate for Diversity within Urban Planning Educational Programs by Andrew J. Greenlee, April Jackson, Ivis Garcia-Zambrana, C. Aujean Lee and Benjamin Chrisinger in Journal of Planning Education and Research
AHCAL Optimisation with Pandora
Creators: name: Tran, Huong Lan
name: Sefkow, Felix
name: Krueger, Katja
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2016

description: CALICE Collaboration Meeting, Kyushu, Japan, 7 Mar 2016 - 9 Mar 2016 ; (2016).
Software compensation in PFlow reconstruction & AHCAL cell size optimisation
Creators: name: Tran, Huong Lan
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2016

description: ECFA - Linear Collidear Workshop 2016, Santander, Spain, 30 May 2016 - 5 Jun 2016 ; (2016).
Family Environment, Neurodevelopmental Risk, and the Environmental Influences on Child Health Outcomes (ECHO) Initiative: Looking Back and Moving Forward
Creators: name: Duarte, Cristiane S.
name: LeWinn, Kaja Z.
name: Elliott, Amy J.
name: Wakschlag, Lauren S.
name: Leve, Leslie D.
name: Blair, Clancy
name: Bush, Nicole R.
name: Deardorff, Julianna
name: O'Shea, T. Michael
name: Neiderhiser, Jenae M.
name: Lewis, Johnnye
name: Posner, Jonathan
name: Lugo-Candelas, Claudia
name: Pieper, Sarah
name: Biezonski, Dominik
name: Nozadi, Sara S.
name: Page, Grier P.
name: Avalos, Lyndsay A.
name: Hertz-Picciotto, Irva
Publisher: name: Frontiers
Year: 2020

description: The family environment, with all its complexity and diverse components, plays a critical role in shaping neurodevelopmental outcomes in children. Herein we review several domains of the family environment (family socioeconomic status, family composition and home environment, parenting behaviors and interaction styles, parental mental health and functioning, and parental substance use) and discuss how these domains influence neurodevelopment, with particular emphasis on mental health outcomes. We also highlight a new initiative launched by the National Institutes of Health, the Environmental influences on Child Health Outcomes (ECHO) program. We discuss the role that ECHO will play in advancing our understanding of the impact of the family environment on children's risk for psychiatric outcomes. Lastly, we conclude with important unanswered questions and controversies in this area of research, highlighting how ECHO will contribute to resolving these gaps in our understanding, clarifying relationships between the family environment and children's mental health.
A review of factors influencing vaccination policies and programs for older adults globally
Creators: name: Eiden, Amanda L.
name: Barratt, Jane
name: Nyaku, Mawuli K.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Policies and programs to increase vaccine coverage rates among adults 50 years of age or older are limited and vaccine uptake is often suboptimal. Our review evaluated evidence on the effectiveness and success of adult-targeted vaccination interventions and identified literature gaps. Literature was retrieved (2021) from PubMed, Embase, and Google Scholar databases. Outcomes assessed included data on an intervention’s effectiveness and impact on vaccine uptake. Interventions were characterized thematically: affordability (n = 9), awareness (n = 25), and vaccination access (n = 6); and included influenza, pneumococcal, tetanus-containing, and herpes zoster vaccines. Interactive interventions directed toward patients, including provider-led educational initiatives and provider recommendations showed more positive associations than less interactive interventions, such as posters and reminder-recall letters. Provider interventions, including awareness campaigns, incentives, affordability efforts, or vaccination site expansion generally showed positive associations. Combining interventions was found to be successful across several studies. Barriers and interventions varied for population subgroups, therefore, tailoring programs is critical.
Additional file 1 of Cost-effectiveness and budget impact of adding tranexamic acid for management of post-partum hemorrhage in the Indian public health system
Creators: name: Joshi, Beena Nitin
name: Shetty, Siddesh Sitaram
name: Moray, Kusum Venkobrao
name: Chaurasia, Himanshu
name: Sachin, Oshima
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 1. RR parameter calculation for TXA control and RR parameter for death from excel sheet.
Fast Groupwise Registration Using Multi-Level and Multi-Resolution Graph Shrinkage
Creators: name: Dong, Pei
name: Cao, Xiaohuan
name: Yap, Pew-Thian
name: Shen, Dinggang
Publisher: name: Springer Nature
Year: 2019

description: Groupwise registration aligns a set of images to a common space. It can however be inefficient and ineffective when dealing with datasets with significant anatomical variations. To mitigate these problems, we propose a groupwise registration framework based on hierarchical multi-level and multi-resolution shrinkage of a graph set. First, to deal with datasets with complex inhomogeneous image distributions, we divide the images hierarchically into multiple clusters. Since the images in each cluster have similar appearances, they can be registered effectively. Second, we employ a multi-resolution strategy to reduce computational cost. Experimental results on two public datasets show that our proposed method yields state-of-the-art registration accuracy with significantly reduced computational time.
Cost-effectiveness of the recombinant zoster vaccine (RZV) against herpes zoster: An updated critical review
Creators: name: Giannelos, Nikolaos
name: Ng, Cheryl
name: Curran, Desmond
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: The objective of this study was to critically review the cost-effectiveness (CE) of the recombinant zoster vaccine (RZV) against herpes zoster (HZ). A literature review was conducted in PubMed, Embase, and Cochrane between January 1, 2017, and February 28, 2022, and on select public healthcare agency websites to identify and collect data from CE studies comparing RZV to zoster vaccine live (ZVL) or to no vaccination. Study characteristics, inputs, and outputs were collected. The overall CE of RZV was assessed. RZV vaccination against HZ is cost-effective in 15 out of 18 studies included in the present review. Varying incremental cost-effectiveness ratios (ICERs) observed may be associated with different assumptions on the duration of protection of RZV, as well as different combinations of structural and disease-related study (model) inputs driving the estimation of ICERs. What is the context? • Herpes zoster, also known as shingles, may cause painful rashes and skin alterations. • Chronic pain, also referred to as post-herpetic neuralgia, may persist for months or even years after the initial rash. • The disease is caused by reactivation of the varicella zoster virus. • The recombinant zoster vaccine (RZV) and the zoster vaccine live (ZVL) are approved for the prevention of herpes zoster and post-herpetic neuralgia. • We reviewed published evidence from the past 5 years on RZV. What is new? • Out of 18 selected studies, RZV vaccination against herpes zoster and post-herpetic neuralgia is cost-effective in 15. • In the 15 studies establishing RZV cost-effectiveness, RZV is always cost-effective or frequently cost-saving in direct comparisons to ZVL, when applicable. • RZV was found cost-saving in several immune-compromised populations. What is the impact? • The overview of the currently available body of evidence related to cost-effectiveness of RZV may help informing decision makers about the value of vaccination against herpes zoster.
Fecal metabolomics reveals products of dysregulated proteolysis and altered microbial metabolism in obesity-related osteoarthritis
Creators: name: Rushing, B.R.
name: Pathmasiri, W.
name: Sumner, S.C.J.
name: Arbeeva, L.
name: Nelson, A.E.
name: Li, Y.-Y.
name: Loeser, R.F.
name: Azcarate-Peril, M.A.
name: McRitchie, S.
name: Qian, Y.
Publisher: name: Elsevier
Year: 2021

description: OBJECTIVE: The objective of this exploratory study was to determine if perturbations in gut microbial composition and the gut metabolome could be linked to individuals with obesity and osteoarthritis (OA). METHODS: Fecal samples were collected from obese individuals diagnosed with radiographic hand plus knee OA (n = 59), defined as involvement of at least 3 joints across both hands, and a Kellgren-Lawrence (KL) grade 2-4 (or total knee replacement) in at least one knee. Controls (n = 33) were without hand OA and with KL grade 0-1 knees. Fecal metabolomes were analyzed by a UHPLC/Q Exactive HFx mass spectrometer. Microbiome composition was determined in fecal samples by 16 S ribosomal RNA amplicon sequencing (rRNA-seq). Stepwise logistic regression models were built to determine microbiome and/or metabolic characteristics of OA. RESULTS: Untargeted metabolomics analysis indicated that OA cases had significantly higher levels of di- and tripeptides and significant perturbations in microbial metabolites including propionic acid, indoles, and other tryptophan metabolites. Pathway analysis revealed several significantly perturbed pathways associated with OA including leukotriene metabolism, amino acid metabolism and fatty acid utilization. Logistic regression models selected metabolites associated with the gut microbiota and leaky gut syndrome as significant predictors of OA status, particularly when combined with the rRNA-seq data. CONCLUSIONS: Adults with obesity and knee plus hand OA have distinct fecal metabolomes characterized by increased products of proteolysis, perturbations in leukotriene metabolism, and changes in microbial metabolites compared with controls. These metabolic perturbations indicate a possible role of dysregulated proteolysis in OA.