cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Building the ATLAS ITk Strip detector: a journey from sensors to multi-module staves.
Creators: name: Capocasa, Francesca
Publisher: name: Brandeis University
Year: 2023
Subjects: ATLAS
Electronic detector readout
ITk
Silicon detector
Silicon Strip detector
Applied Physics

description: For the High-Luminosity upgrade of the Large Hadron Collider, the instantaneous luminosity of the LHC is expected to reach unprecedented values, resulting in about 200 proton-proton interactions in a typical bunch crossing. To cope with the resulting increase in occupancy, bandwidth and radiation damage, the current ATLAS Inner Detector will be replaced by an all-silicon system, the Inner Tracker (ITk). In the outermost part of this tracker is the Strip Detector, which has a highly modular design, with a barrel region and two end-caps. This thesis explores various phases of the ITk project, from prototyping to pre-production, with a particular focus on assembly procedures, performance characterization, and quality control and assurance measurements for the detector components and system employed at Brookhaven National Laboratory. It covers the assembly techniques adopted for assembling hybrids and modules, which have been refined based on feedback from metrology and electrical tests. A detailed examination of the detector system performance, beginning with the setup, procedure, and results of the first fully-instrumented prototype stave developed at BNL, and culminating with the results and challenges encountered during the latest phase, is offered. This thesis will delve into the performance of the pre-production staves and offerinsights into how they have been optimized to achieve the ITk project’s objectives.
An outbreak of carbapenem-resistant OXA-48 – producing Klebsiella pneumonia associated to duodenoscopy
Creators: name: Kola, Axel
name: Piening, Brar
name: Pape, Ulrich-Frank
name: Veltzke-Schlieker, Wilfried
name: Kaase, Martin
name: Geffers, Christine
name: Wiedenmann, Bertram
name: Gastmeier, Petra
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Carbapenemase-producing Enterobacteriaceae (CPE) have become a major problem for healthcare systems worldwide. While the first reports from European hospitals described the introduction of CPE from endemic countries, there is now a growing number of reports describing outbreaks of CPE in European hospitals. Here we report an outbreak of Carbapenem-resistant K. pneumoniae in a German University hospital which was in part associated to duodenoscopy. Findings Between December 6, 2012 and January 10, 2013, carbapenem-resistant K. pneumoniae (CRKP) was cultured from 12 patients staying on 4 different wards. The amplification of carbapenemase genes by multiplex PCR showed presence of the bla OXA-48 gene. Molecular typing confirmed the identity of all 12 isolates. Reviewing the medical records of CRKP cases revealed that there was a spatial relationship between 6 of the cases which were located on the same wards. The remaining 6 cases were all related to endoscopic retrograde cholangiopancreatography (ERCP) which was performed with the same duodenoscope. The outbreak ended after the endoscope was sent to the manufacturer for maintenance. Conclusions Though the outbreak strain was also disseminated to patients who did not undergo ERCP and environmental sources or medical personnel also contributed to the outbreak, the gut of colonized patients is the main source for CPE. Therefore, accurate and stringent reprocessing of endoscopic instruments is extremely important, which is especially true for more complex instruments like the duodenoscope (TJF Q180V series) involved in the outbreak described here.
title: MicroDB
title: A Highly Available Data Store for Service-Oriented Architecture
titleType: Subtitle
Creators: name: Ho, Julian
Publisher: name: Brandeis University
Year: 2021
Subjects: Microserivces
Service-oriented Architecture
Databases
Datastore
Distributed Systems

description: MicroDB is a distributed data store for providing highly available, isolated data access to existing R-DBMS or other data stores designed for a service-oriented architecture. This paper describes the motivation behind MicroDB, the design and implementation of its access and replication layers, and how it can aid in tackling challenges associated with migrating to a full service-oriented architecture from a monolithic architecture. Lastly, we will present experimental results and comparisons with existing solutions.
title: From soldiers to citizens
title: the civil reintegration of demobilized soldiers of the German Wehrmacht and the Imperial Japanese Army after unconditional surrender in 1945
titleType: Subtitle
Creators: name: Schneider, Birgit
Publisher: name: Washington State University
Year: 2010
Subjects: Reconstruction, 1939-1951

description: Demilitarization and democratization of Germany and Japan constituted the Allies essential goals of the Second World War; when the war was concluded and plans for postwar settlements were set up, the two countries militaries were dissolved and their personnel disbanded. Demobilized soldiers returned to their war-maimed countries as soon as they were released from the custody of the respective Allied power to which they had surrendered. Most returned before 1948, although for some, Soviet captivity meant up to ten years of forced labor. This dissertation analyzes the situation of demobilized soldiers after their return home. It examines how returnees former soldiers, now civilians were perceived and treated by the American occupation in the American zone of occupation of Germany and in Japan, and by their own governments. Demobilized soldiers were, based on their indoctrination in the military and their engagement in the fighting of the war, understood as potential proponents of militarism, and as adversaries of democracy by the occupation. The German and Japanese administrations saw them in a more productive light, as a significant economic force and as potential supporters of democracy. As a consequence, policies with regard to demobilized soldiers oscillated between restrictions imposed by the occupation and material support provided by the national governments; between demilitarization and reconstruction. The analysis of archival material has yielded that the material provisions proved to be decisive in assuring the integration of former soldiers in postwar civil society, and in avoiding their alienation with the democratic governments. Demobilized soldiers were at the same time the embodiment and the culprits of defeat, both perpetrators and victims of militarism. Their numbers and presence in contemporary discourse underscore their significance in postwar German and Japanese societies. Tracing the transition from war to peace through the study of veterans under American occupation, this dissertation shows how the occupation as well as German and Japanese policies were successful despite their very different motivations in preventing the re-emergence of militarism, and in integrating veterans into German and Japanese civil society.
Analysis and mitigation of the adverse effects of voltage sags and swells on wind farms
Creators: name: Das, Tapash Kumar
Publisher: name: Swinburne
Year: 2024

description: Wind farms have become an important source of sustainable electricity generation as renewable energy is becoming more and more popular around the world. The widespread adoption of wind farms causes some new problems. Wind generators are prone to damage during electricity grid instability and, therefore, some sort of protection is required for continuous operation of wind generators. This thesis focuses on the design of novel protection mechanism for wind generators during electricity grid instability. This will make the adoption of wind farms more feasible.
Generationally-Linked Archaeology
Creators: name: Carriere, Ed
name: Stapp, Darby C
name: Croes, Dale R.
Publisher: name: Washington State University
Year: 2018
Subjects: Wet archaeological sites
Biderbost wet site
Archaeology

description: The research involved the efforts of a wet archaeological site specialist (Dale Croes) and a Master Basketmaker and Elder from the Suquamish Tribe (Ed Carriere), who joined together to replicate and scientifically analyze the 2,000-year-old basketry collection from the Biderbost wet site, Snoqualmie Tribal Territory, housed at the University of Washington (UW) Burke Museum Archaeology Program (Figure 1). Working on this analysis and replication project over the past four years, we concluded that it was not enough to call this a case of Experimental Archaeology; we describe our work as a new approach termed Generationally-Linked Archaeology, an approach that chronologically connects from both directions, linking contemporary cultural specialists with ancient and ancestral basketmakers through the science of archaeology. We present our approach here after publicly presenting our efforts to both indigenous and scientific archaeological audiences, including Native peoples at the Northwest Native American Basketweavers Association, Indigenous Ainu of northern Japan, and at a National Maori Weavers conference in New Zealand, and to archaeological scientists at two annual SAA conferences, the Wetland Archaeological Research Project (WARP) 30th Anniversary Conference in Bradford, England, and a Wetland Archaeology Conference in central France.
miR-199a-3p and miR-214-3p improve the overall survival prediction of muscle- invasive bladder cancer patients after radical cystectomy
Creators: name: Ecke, Thorsten H.
name: Stier, Katja
name: Weickmann, Sabine
name: Zhao, Zhongwei
name: Buckendahl, Laura
name: Stephan, Carsten
name: Kilic, Ergin
name: Jung, Klaus
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: To improve the clinical decision-making regarding further treatment management and follow-up scheduling for patients with muscle-invasive bladder cancer (MIBC) after radical cystectomy (RC), a better prediction accuracy of prognosis for these patients is urgently needed. The objective of this study was to evaluate the validity of differentially expressed microRNAs (miRNAs) based on a previous study as prognostic markers for overall survival (OS) after RC in models combined with clinicopathological data. The expression of six miRNAs (miR-100-5p, miR-130b-3p, miR-141-3p, miR-199a-3p, miR-205-5p, and miR-214-3p) was measured by RT-qPCR in formalin-fixed, paraffin-embedded tissue samples from 156 MIBC patients who received RC in three urological centers. Samples from 2000 to 2013 were used according to their tissue availability, with follow-up until June 2016. The patient cohort was randomly divided into a training (n = 100) and test set (n = 56). Seventy-three samples from adjacent normal tissue were used as controls. Kaplan–Meier, univariate and multivariate Cox regression, and decision curve analyses were carried out to assess the association of clinicopathological variables and miRNAs to OS. Both increased (miR-130b-3p and miR-141-3p) and reduced (miR-100-5p, miR-199a- 3p, and miR-214-3p) miRNA expressions were found in MIBC samples in comparison to nonmalignant tissue samples (P < 0.0001). miR-199a-3p and miR-214-3p were independent markers of OS in Cox regression models with the significant clinicopathological variables age, tumor status, and lymph node status. The prediction model with the clinicopathological variables was improved by these two miRNAs in both sets. The predictive benefit was confirmed by decision curve analysis. In conclusion, the inclusion of both miRNAs into models based on clinical data for the outcome prediction of MIBC patients after RC could be a valuable approach to improve prognostic accuracy.
Facilitating the reuse process in an object oriented environment by learning from observation.
Creators: name: Rovel, Thierry.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1993
Subjects: subject: Computer Science.

description: The aim of this research is to ease the reuse of components in an Object-Oriented library. We ease the three main processes included in reuse: searching for, understanding and adapting components. The novelty of this approach is that all the information needed to achieve these improvements is learned automatically by spying on the programmer's actions. This thesis describes a model for a learner in an Object-Oriented environment. A specific implementation for the Smalltalk language, called LEARNIST (Learning to EAse Reuse IN SmallTalk), is described and illustrated with examples.
Aboriginal people and discrimination in the justice system: A survey of Manitoba inmates and related literature.
Creators: name: McMahon, Thomas.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1993
Subjects: subject: Law.

description: The thesis examines how the criminal justice system treats Aboriginal people. While the survey is principally concerned with examining evidence of systemic discrimination, it points out from the beginning that an ineffective justice system needs reform even if it is fair in all respects. I believe the present justice system generally does not protect Aboriginal victims and communities, and intrudes excessively into the lives of offenders without realizing substantial benefits. The thesis concludes that discrimination against Aboriginal persons is widespread in the criminal justice system, and that the system is not serving Aboriginal people well, whether as victims, offenders, or communities. One of the recommendations proposed is for the establishment of Aboriginal justice systems, including criminal law-making powers. Other recommendations are directed at that part of the justice system that will always be governed within the present jurisdictional structures, and calls for blunt measures to make the justice system more effective in protecting victims and reducing discrimination against Aboriginal persons. The thesis concludes that the problems with the justice system are fundamental and in many ways involve inherent contradictions in its operation. (Abstract shortened by UMI.)
Facilitated interprofessional implementation of a physical rehabilitation guideline for stroke in inpatient settings: process evaluation of a cluster randomized trial
Creators: name: Salbach, Nancy M
name: Wood-Dauphinee, Sharon
name: Desrosiers, Johanne
name: Eng, Janice
name: Graham, Ian D
name: Jaglal, Susan B
name: Korner-Bitensky, Nicol
name: MacKay-Lyons, Marilyn
name: Mayo, Nancy E
name: Richards, Carol L
name: Teasell, Robert W
name: Zwarenstein, Merrick
name: Bayley, Mark T
Publisher: name: BioMed Central
Year: 2017

description: Background: The Stroke Canada Optimization of Rehabilitation by Evidence-Implementation Trial (SCORE-IT) showed that a facilitated knowledge translation (KT) approach to implementing a stroke rehabilitation guideline was more likely than passive strategies to improve functional walking capacity, but not gross manual dexterity, among patients in rehabilitation hospitals. This paper presents the results of a planned process evaluation designed to assess whether the type and number of recommended treatments implemented by stroke teams in each group would help to explain the results related to patient outcomes. Methods: As part of a cluster randomized trial, 20 rehabilitation units were stratified by language and allocated to a facilitated or passive KT intervention group. Sites in the facilitated group received the guideline with treatment protocols and funding for a part-time nurse and therapist facilitator who attended a 2-day training workshop and promoted guideline implementation for 16 months. Sites in the passive group received the guideline excluding treatment protocols. As part of a process evaluation, nurses, and occupational and physical therapists, blinded to study hypotheses, were asked to record their implementation of 18 recommended treatments targeting motor function, postural control and mobility using individualized patient checklists after treatment sessions for 2 weeks pre- and post-intervention. The percentage of patients receiving each treatment pre- and post-intervention and between groups was compared after adjusting for clustering and covariates in a random-effects logistic regression analysis. Results: Data on treatment implementation from nine and eight sites in the facilitated and passive KT group, respectively, were available for analysis. The facilitated KT intervention was associated with improved implementation of sit-to-stand (p = 0.028) and walking (p = 0.043) training while the passive KT intervention was associated with improved implementation of standing balance training (p = 0.037), after adjusting for clustering at patient and provider levels and covariates. Conclusions: Despite multiple strategies and resources, the facilitated KT intervention was unsuccessful in improving integration of 18 treatments concurrently. The facilitated approach may not have adequately addressed barriers to integrating numerous treatments simultaneously and complex treatments that were unfamiliar to providers. Trial registration Unique identifier- NCT00359593
Avortement sexualité et politique : la non-reconnaissance de l'individualité des femmes.
Creators: name: Portilla, Hilda Joyce.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Women's Studies.

description: Cette thèse se propose de comprendre le débat sur l'avortement au plan international en analysant le contenu discursif des Rapports des Conférences sur la population des Nations-Unies. Une comparaison a été établie entre les rencontres de Bucarest 1974, de Mexico 1984 et celle du Caire en 1994. Au Caire, le débat sur l'avortement a été un sujet dominant, ce qui justifie son analyse approfondie. Considérant l'importance politique de la liberté de décision des femmes en la matière, la thèse tente de répondre à la question suivante: Quels sont les discours qui dominent le débat sur l'avortement lors de la conférence du Caire et que suggèrent-ils sur la représentation des femmes en tant qu'individus? Notre hypothèse est que dominent deux types de discours dans le débat sur l'avortement au plan international: un discours scientifique et un discours religieux. Ils s'opposent idéologiquement en évoquant des arguments moraux ou rationnels, et présentent le "problème de la surpopulation" ou le "caractère sacré de la fécondité" comme des vérités. Des idées de Michel Foucault, en particulier celles qui rendent compte de la relation entre sexualité et politique, ont servi comme schéma de réflexion. Les discours ont été replacés dans un schéma analytique plus vaste qui porte sur le bio-pouvoir ou la "technologie politique des individus", ce qui permet de mieux comprendre l'évolution historique du contrôle des populations et de la planification familiale. On s'aperçoit ainsi que les discours dominants qui s'opposent dans le débat sur l'avortement, ont tout de même quelque chose en commun: une vision limitatrice de l'individualité des femmes.
The chosen few: Mycobacterium tuberculosis isolates for IMPAc-TB
Creators: name: Kim, Ho D.
name: Baldwin, Susan L.
name: Barrett, Holly W.
name: Berube, Bryan J.
name: Harband, Matthew H.
name: Urdahl, Kevin B.
name: Fortune, Sarah M.
name: Cohen, Sara B.
name: Plumlee, Courtney R.
name: Liu, Qingyun
name: Larsen, Sasha E.
name: Coler, Rhea N.
name: Abdelaal, Hazem F. M.
Publisher: name: Frontiers Media SA
Year: 2024

description: The three programs that make up the Immune Mechanisms of Protection Against Mycobacterium tuberculosis Centers (IMPAc-TB) had to prioritize and select strains to be leveraged for this work. The CASCADE team based at Seattle Children’s Research Institute are leveraging M.tb H37Rv, M.tb CDC1551, and M.tb SA161. The HI-IMPACT team based at Harvard T.H. Chan School of Public Health, Boston, have selected M.tb Erdman as well as a novel clinical isolate recently characterized during a longitudinal study in Peru. The PHOENIX team also based at Seattle Children’s Research Institute have selected M.tb HN878 and M.tb Erdman as their isolates of choice. Here, we describe original source isolation, genomic references, key virulence characteristics, and relevant tools that make these isolates attractive for use. The global context for M.tb lineage 2 and 4 selection is reviewed including what is known about their relative abundance and acquisition of drug resistance. Host–pathogen interactions seem driven by genomic differences on each side, and these play an important role in pathogenesis and immunity. The few M.tb strains chosen for this work do not reflect the vast genomic diversity within this species. They do, however, provide specific virulence, pathology, and growth kinetics of interest to the consortium. The strains selected should not be considered as “representative” of the growing available array of M.tb isolates, but rather tools that are being used to address key outstanding questions in the field.
Determining preference orders based on a majority margin matrix
Creators: name: BURY, Hanna
name: WAGNER, Dariusz
Publisher: name: Wrocław University of Technology, Wrocław University of Economics, Polish Operational and Systems Research Society
Year: 2013
Subjects: profile of preference orders, pairwise comparisons, outranking matrix, majority margin matrix, Debord’s method

description: OPERATIONS RESEARCH AND DECISIONS; ISSN 2081-8858
Solids transportation, heat and mass transfer in rotary dryers
Creators: name: Song, Yang
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Engineering, Chemical.
subject: Engineering, Mechanical.

description: In this thesis, the mechanisms of solids transportation, heat and mass transfer within rotary dryers were first examined. Some experimental data obtained in pilot-scale and industrial rotary dryers were used to investigate the influences of moisture content of solids and gas temperature on solids transportation, typically on solids mean residence time distribution, and on heat and mass transfer to estimate the volumetric heat and mass transfer coefficients. One pilot-scale rotary dryer with direct contact between the gas and the solids with co-current flow has been designed, constructed and tested in our laboratory. It mainly consists of four parts: an electric fan, an electric heater, a solids feeding system and a rotary cylinder. Numerous experiments were performed to investigate the dynamic characteristics of solids transportation in this pilot-scale rotary dryer. (Abstract shortened by UMI.)
Self-defeating vs. self-deprecating humour: a case of being laughed at vs. laughed with?
Creators: name: Brown, Robyn
Publisher: name: Swinburne
Year: 2024

description: Self-deprecating humour involves gently poking fun at oneself, whilst self-defeating humour is the excessive use of disparaging remarks about oneself. As these two humour styles may present in the same way, in this thesis it was examined whether observers could differentiate between the two and what this perception was based on (e.g., target self-esteem, funniness ratings or observer mood?). Humour plays an essential role in interpersonal relationships and can communicate information about an individual, however, research examining how humour is perceived is limited. Therefore this thesis addressed this gap examining the way in which targets using self-disparaging humour are perceived.
Chromaffin cell scinderin redistribution, cortical F-actin disassembly and secretion are evoked by histamine through activation of the H(1) receptor-phophatidylinositol 4,5-bisphosphate transduction pathway.
Creators: name: Zhang, Li.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Health Sciences, Pharmacology.

description: Nicotinic stimulation of chromaffin cells causes disassembly of cortical F-actin networks and redistribution of scinderin, a Ca$\sp{2+}$-dependent F-actin severing protein. These Ca$\sp{2+}$-dependent events precede exocytosis. Activation of scinderin by Ca$\sp+$ may cause severing of F-actin and disassembly of actin networks leaving cortical areas of low cytoplasmic viscosity which are the sites of exocytosis. Histamine is a known chromaffin cell secretagogue which induces Ca$\sp+$-dependent release of catecholamines. However, conflicting evidence exists as to the source of Ca$\sp{2+}$ utilized in histamine-evoked secretion. Here we report that histamine-H$\sb1$ receptor activation induces scinderin redistribution, F-actin disassembly and catecholamine release. Histamine evoked similar patterns of distribution of scinderin and filamentous actin. The rapid responses to histamine occurred in the absence of extracellular Ca$\sp{2+}$ and were triggered by release of Ca$\sp{2+}$ from intracellular stores. The trigger for the release of Ca$\sp{2+}$ was inositol 1,4,5-triphosphate (IP$\sb3$) since U-73122, a phospholipase C inhibitor, but not its inactive isomer (U-73343), inhibited the increases in IP$\sb3$, intracellular Ca$\sp{2+}$, scinderin redistribution, cortical F-actin disassembly and catecholamine release in response to histamine. Thapsigargin, an agent known to mobilize intracellular Ca$\sp{2+}$, blocked the rise in intracellular Ca$\sp{2+}$, scinderin redistribution, F-actin disassembly and catecholamine secretion in response to histamine. However, thapsigargin did not modify the increase in IP$\sb3$ induced by histamine. Calphostin C and chelerythrine, two inhibitors of protein kinase C, blocked all responses to histamine with the exception of the release of Ca$\sp{2+}$ from intracellular stores. This suggests that protein kinase C is involved in histamine induced response. The results also show that without F-actin disassembly, raises in intracellular Ca$\sp{2+}$ are not by themselves capable of triggering catecholamine release.
Caveolin-1 and CDC42 mediated endocytosis of silica-coated iron oxide nanoparticles in HeLa cells
Creators: name: Bohmer, Nils
name: Jordan, Andreas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Nanomedicine is a rapidly growing field in nanotechnology, which has great potential in the development of new therapies for numerous diseases. For example iron oxide nanoparticles are in clinical use already in the thermotherapy of brain cancer. Although it has been shown, that tumor cells take up these particles in vitro, little is known about the internalization routes. Understanding of the underlying uptake mechanisms would be very useful for faster and precise development of nanoparticles for clinical applications. This study aims at the identification of key proteins, which are crucial for the active uptake of iron oxide nanoparticles by HeLa cells (human cervical cancer) as a model cell line. Cells were transfected with specific siRNAs against Caveolin-1, Dynamin 2, Flotillin-1, Clathrin, PIP5Kα and CDC42. Knockdown of Caveolin-1 reduces endocytosis of superparamagnetic iron oxide nanoparticles (SPIONs) and silica-coated iron oxide nanoparticles (SCIONs) between 23 and 41%, depending on the surface characteristics of the nanoparticles and the experimental design. Knockdown of CDC42 showed a 46% decrease of the internalization of PEGylated SPIONs within 24 h incubation time. Knockdown of Dynamin 2, Flotillin-1, Clathrin and PIP5Kα caused no or only minor effects. Hence endocytosis in HeLa cells of iron oxide nanoparticles, used in this study, is mainly mediated by Caveolin-1 and CDC42. It is shown here for the first time, which proteins of the endocytotic pathway mediate the endocytosis of silica-coated iron oxide nanoparticles in HeLa cells in vitro. In future studies more experiments should be carried out with different cell lines and other well-defined nanoparticle species to elucidate possible general principles.
Monophyly and intrarelationships of the family Pleuronectidae (Pleuronectiformes), with a revised classification.
Creators: name: Cooper, J. Andrew.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Biology, Zoology.

description: A cladistic analysis of interrelationships for 53 (of 58) pleuronectid (Order Pleuronectiformes) species was performed using 106 morphologial and osteological characters. The analysis resulted in a 50% majority-rule consensus tree of 128 equally parsimonious cladograms (heuristic search, 403 steps, ci = 0.33, ri = 0.79). Only five of 47 resolved nodes were observed in less than 100% of the cladograms. These five nodes are restricted to interrelationships within one subfamily. The Pleuronectidae (sensu Chapleau and Keast, 1988) are monophyletic based on ten synapomorphies. In addition, five subfamilies were defined Hippoglossinae, Eopsettinae, Lyonsettinae, Hippoglossoidinae and Pleuronectinae. The largest subfamily, the Pleuronectinae, was further subdivided into four tribes. Psettichyini, Isopsettini, Microstomini and Pleuronectini. The interrelationships established within Pleuronectidae provide a strong foundation for a simplified yet phylogenetically informative taxonomic nomenclature. The genera Atherestes and Reinhardtius; Embassichthys, Errex, Glyptocephalus, Tanakius and Microstomus; Hypsopsetta and Pleuronichthys are regrouped in Reinhardtus; Microstomus and Pleuronichthys, respectively. To preserve the monophyletic status of Eopsetta, E. exilis was reassigned to the genus Lyopsetta (Lyopsettinae). The genus Pleuronectes (as defined by Sakamoto, 1984a) is polyphyletic. It now includes only five species: Pleuronectes glacialis, P. pinnifasciatus, P. platessa, P. putnami and P. quadrituberculatus. Other Pleuronectes species are reclassified in Isopsetta, Limanda, Parophrys, Platichthys, Psettichys, and Pseudopleuronectes. The monophyletic status of the genus Limanda (six species) is uncertain based on unresolved relationships between these species and other taxa in the tribe Pleuronectini.
Studying CD8+ T cell immune response using in vitro live cell imaging
Creators: name: Zibaei, Kajal
Publisher: name: Swinburne
Year: 2024

description: CD8+ T cells are a powerful branch of the adaptive immune system. They contribute to control of infection and cancer, are involved in autoimmune disease, and mediate transplant rejections.
Antigen specific naïve CD8+ T cells recognise their cognate antigen on the surface of dendritic cells (DC) and become activated. Once activated, they undergo a phase of rapid proliferation and differentiation. Memory differentiation is a hallmark of adoptive immunity and provide the host with long lasting protection against the same antigen. Many researchers, mainly using population based analysis, have been trying to elucidate the mechanisms that regulate memory differentiation. However, how the initial response of CD8+ T cells and memory differentiation are regulated is still a challenging subject in immunology. Studying the immune response of T cells at the level of single cells can provide insight into many illusive aspects of the initial response and production memory cells. In this thesis I studied the clonal expansion of naïve CD8+ T cells by quantifying cell number over time.
Questionnaire on causative-anticausative verb pairs (based on Haspelmath
Creators: name: Dom, Sebastian
name: Kanijo, Ponsiano
name: Bar-el, Leora
name: Petzell, Malin
Publisher: name: Zenodo
Year: 2020
Subjects: questionnaire
fieldwork
Swahili
valency
causative-anticausative alternation

description: This sentence questionnaire was created by the four members of the research project ‘To break or be broken — A study of valency-decreasing alternations in East Ruvu Bantu languages’. The project aims to study valency-decreasing alternations in Kagulu, Kami, Kutu, Kwere, Luguru and Zalamo, six underdescribed East Ruvu Bantu languages spoken in Tanzania. The questionnaire is based on the lexical verb list published in Haspelmath (1993), consisting of 31 verb meanings, to study the coding of the anticausative-causative alternation. The questionnaire is tailored to the specific linguistic and cultural area of the research project, and is not intended to be of use for every language or linguistic community. The questionnaire is entirely bilingual English-Swahili. TL stands for ‘target language’.
description: {"references": ["Haspelmath, Martin. 1993. More on the typology of inchoative/causative verb alternations. In Comrie, Bernard & Polinsky, Maria (eds), Causatives and transitivity, 87-120. Amsterdam: John Benjamins."]}
Significant otherness: Herodotos' use of a dominant female motif to illustrate the superiority of the Greeks.
Creators: name: McAllister, Michael A.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Literature, Classical.

description: This Thesis examines the Hellenocentric trend in Herodotos' History, and the use of a dominant female motif to illustrate the superiority of the Greeks. It has been pointed out that Herodotos "is an important and generally neglected witness to fifth-century assumptions and attitudes about women in society" (Dewald 1981, 91). This statement certainly holds true for much of Herodotos' ethnographic material, and he seems to escape the narrow ethnocentrism reflected in later writers. However, Herodotos was much more than an ethnographer, and therefore much more than a witness. He was primarily an artist, and undeniably influenced by Homer. His own ideas concerning limit, transgression, and nomos are discernible throughout his work. Free invention and manipulation of material, without distortion of facts, were, in my opinion, not only acceptable to Herodotos, but necessary to achieve the desired composition. The subjective nature of Herodotos' work can be established, and his own personal biases must therefore be considered. Two of these biases need concern us: the one towards women, and the other towards the Persians. Herodotos certainly acknowledges the value and necessity of a reciprocity between men and women in the cultures he describes, and yet his perception undoubtedly reflects that of a fifth century Greek male. He demonstrates his own authorial bias concerning women in 1.196, where men are dearly more important than women. Here Herodotos gives his personal stamp of approval. The 'otherness' of Persia in fifth century Greek tragedy has been observed in recent years, and the theory that Persia is described as a diametrically opposed 'other' culture in Herodotos has also been suggested. It is, however, a combination of facts together with elements of 'otherness' and Herodotos' own artistic technique that make up Persian culture in the History . If male supremacy was the norm in Herodotos' own culture, what would be the norm in the anti-Greek 'other' culture? The answer is a society where women seem to be in control and seem to be superior to men, and this is the Persian society we see in Herodotos.
The utility of indirect standardization for estimating community health status.
Creators: name: Strike, Carol Janice.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Health Sciences, Public Health.

description: Indirect standardization was used to produce estimates of the prevalence of selected risk factors and health status indicators for all health units in Ontario, based on their socio-demographic characteristics and on the relationships between these socio-demographic variables and the health variables of interest, as measured by the Ontario Health Survey (OHS). Socio-demographic variables were drawn from both the OHS and the 1986 Census of Canada. In addition, the validity of the estimates was assessed. A total of 13 combinations of predictor variables were used to estimate 18 selected health status indicators and risk factors. Results showed that the choice of predictor variables used for estimation can have a substantial impact on the error associated with a set of estimates. As well, it was found that the dispersion of the estimates was reduced in comparison to the true values. The ranking of the estimates was found to vary from poor to good. In addition, estimates were shown to be better than using the provincial value as the estimate for each health unit value. Comparison by region showed that estimates for northern regions had somewhat more error than estimates for other regions and that addition of a geographic identifier reduced the amount of error among the estimates. Given all these results, it was concluded that this type of methodology does not appear to be adequate to meet the information needs for health units but that other methods such as regression might produce better results.
Regulation of Liver Metabolism by the Endosomal GTPase Rab5
Creators: name: Zeigerer, Anja
name: Bogorad, Roman L.
name: Sharma, Kirti
name: Gilleron, Jerome
name: Seifert, Sarah
name: Sales, Susanne
name: Berndt, Nikolaus
name: Bulik, Sascha
name: Marsico, Giovanni
name: D’Souza, Rochelle C. J.
name: Lakshmanaperumal, Naharajan
name: Meganathan, Kesavan
name: Natarajan, Karthick
name: Sachinidis, Agapios
name: Dahl, Andreas
name: Holzhütter, Hermann-Georg
name: Shevchenko, Andrej
name: Mann, Matthias
name: Koteliansky, Victor
name: Zerial, Marino
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie

description: The liver maintains glucose and lipid homeostasis by adapting its metabolic activity to the energy needs of the organism. Communication between hepatocytes and extracellular environment via endocytosis is key to such homeostasis. Here, we addressed the question of whether endosomes are required for gluconeogenic gene expression. We took advantage of the loss of endosomes in the mouse liver upon Rab5 silencing. Strikingly, we found hepatomegaly and severe metabolic defects such as hypoglycemia, hypercholesterolemia, hyperlipidemia, and glycogen accumulation that phenocopied those found in von Gierke’s disease, a glucose-6-phosphatase (G6Pase) deficiency. G6Pase deficiency alone can account for the reduction in hepatic glucose output and glycogen accumulation as determined by mathematical modeling. Interestingly, we uncovered functional alterations in the transcription factors, which regulate G6Pase expression. Our data highlight a requirement of Rab5 and the endosomal system for the regulation of gluconeogenic gene expression that has important implications for metabolic diseases.
The impact of environmental shocks due to climate change on intimate partner violence: A structural equation model of data from 156 countries
Creators: name: Gibbs, Andrew
name: Hatcher, Abigail
name: Jordaan, Esme
name: Mannell, Jenevieve
name: Brown, Laura J.
Publisher: name: Public Library of Science
Year: 2024

description: The impact of climate change on human societies is now well recognised. However, little is known about how climate change alters health conditions over time. National level data around climate shocks and subsequent rates of intimate partner violence (IPV) could have relevance for resilience policy and programming. We hypothesise that climate shocks are associated with a higher national prevalence of IPV two years following a shock, and that this relationship persists for countries with different levels of economic development. We compiled national data for the prevalence of IPV from 363 nationally representative surveys from 1993 to 2019. These representative data from ever-partnered women defined IPV incidence as any past-year act of physical and/or sexual violence. We also compiled data from the Emergency Events Database (EM DAT) on the national frequency of eight climate shocks from 1920 to 2022 within 190 countries. Using exploratory factor analysis, we fit a three-factor latent variable composed of climate shock variables. We then fit a structural equation model from climate shocks (lagged by two years) and IPV incidence, controlling for (log) national gross domestic product (GDP). National data representing 156 countries suggest a significant relationship between IPV and a climate factor (Hydro-meteorological) composed of storms, landslides and floods (standardised estimate = 0·32; SE = 0·128; p = 0·012). GDP has a moderately large cross-sectional association with IPV (estimate = -0·529; SE = 0·047; p = 0·0001). Other climate shocks (Geological: earthquakes/volcanos; Atmospheric: wildfire/droughts/extreme temperature) had no measurable association with IPV. Model fit overall was satisfactory (RMSEA = 0·064 (95%CI: 0·044–0·084); CFI = 0·91; SRMR = 0·063). Climate shocks have a longitudinal association with IPV incidence in global population-based data. This suggests an urgent need to address the higher prevalence of IPV likely to come about through climate shocks due to climate change. Our analysis offers one way policy makers could track national progress using existing data.
Development of an automatic vehicular heatstroke detection system
Creators: name: David Chua, S. N.
name: Goh, W. J.
name: Lim, S. F.
name: Joseph, A.
name: Oon, Y. B.
name: Sia, C. V.
Publisher: name: Swinburne
Year: 2024

description: The cases of children being left in a car and died of heatstroke are on the rise every year. Car manufacturers have not implemented any sort of alert system that could prevent these unfortunate events from happening. There are many baby car seat alert systems available in the market, however, they are mostly inconsistent and unreliable. There is a need for more effective and efficient alert system to remind the users of their forgotten child. This paper aims to provide solutions to caretakers through application of multiple sensors for integration of a child detection system and also to discover the best placement of the sensors for a more effective system. The selection method is based on experimental setup with a test subject which is a human being. A prototype for the detection system is fabricated and results show a combination of ultrasonic and motion sensors produces the best results. The best position to place the ultrasonic and motion sensor is determined to be above the child seat and in the middle of the car respectively. The prototype of the detection and alert system is validated via a set of assessments to determine its accuracy, adaptability and reliability.
The cloning and characterization of the TIK kinase.
Creators: name: Icely, Pamela L.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Biology, Cell.

description: Protein phosphorylation is a mechanism of modulating protein activity which plays a central role in a wide variety of cellular functions. The ready reversibility of the phosphotransfer reaction makes it well-suited for rapid cellular responses, such as the responses to signals from extracellular stimuli. Members of the protein kinase family have been identified as components of cellular signal tranduction networks, and in fact many protein kinases mediate signals controlling cell growth, differentiation, and development. The work carried out in this thesis describes the cloning and characterization of the TIK kinase, a novel member of the protein kinase family. The TIK kinase was isolated and cloned from murine pre-B cells on the basis of its immunoreactivity with antibodies to phosphotyrosine, and was therefore originally thought to be a protein tyrosine kinase. Characterization of the in vitro and in vivo activity of this kinase, however, revealed that the TIK kinase possesses only serine and threonine phosphorylating ability. A kinase deficient TIK protein, constructed by site-directed mutagenesis, is not immunoreactive with the antiphosphotyrosine antibodies. These observations indicate the phosphoserine and/or phosphothreonine residues may be assuming a conformation within the context of this protein which mimicks the epitope(s) recognized by antiphosphotyrosine antibodies. The gene encoding the TIK kinase is transcribed to produce three distinct messenger RNA (mRNA) transcripts in all murine tissues examined, and in a number of murine leukemic cell lines. In the murine lymphocytic leukemia line L1210, however, three truncated mRNA molecules are produced in addition to the three normal transcripts detected in other tissues. Evidence is presented here that one allele of the TIK gene has undergone a genomic rearrangement in this cell line, and appears to giving rise to the abnormal pattern of mRNA expression observed. A cDNA corresponding to the smallest truncated mRNA transcript encoding the TIK kinase in the L1210 cell line has been obtained, and this cDNA encodes a mutant TIK protein lacking kinase activity. I postulate that the TIK kinase plays some role in the control of growth and differentiation during lymphocyte development, and that the mutation of the TIK gene has contributed to the initiation or maintenance of transformation in the L1210 cell line.
Dorothy Livesay's poetics of desire.
Creators: name: McInnis, Nadine.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Literature, Canadian (English).

description: Dorothy Livesay's poetic exploration of love illuminates the relationship that exists between the individual woman artist and a culture shaped by men's experiences and stories. Chapter 1 surveys the critical treatment of Livesay's love poems, illustrating how theoretical superimposition can distort the subtext which gives the poems their energy and power. Chapter 2 analyses the thematic and imagistic portrayal of the love relationship present in the poems written during early womanhood, and establishes a link between sexuality and textuality. Chapter 3 explores the violent sexual/textual conflicts contained within the intensely erotic poems of Livesay's middle-age, framed by The Unquiet Bed (1967) and Disasters of the Sun (1971). Chapter 4 examines the resolution of these conflicts in the later poetry, starting with Ice Age (1975) and receiving clearest expression in Feeling the Worlds (1984). Livesay achieves a unified and unambiguous voice when she finds a way to unite her eroticism with her political concerns, and she ultimately succeeds in realizing a clear vision of her role as a woman writer.