cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
RotoStep: A Chromosome Dynamics Simulator Reveals Mechanisms of Loop Extrusion
Creators: name: Bloom, K.
name: Friedman, B.
name: Lawrimore, J.
name: Doshi, A.
Publisher: name: NLM (Medline)
Year: 2017

description: ChromoShake is a three-dimensional simulator designed to explore the range of configurational states a chromosome can adopt based on thermodynamic fluctuations of the polymer chain. Here, we refine ChromoShake to generate dynamic simulations of a DNA-based motor protein such as condensin walking along the chromatin substrate. We model walking as a rotation of DNA-binding heat-repeat proteins around one another. The simulation is applied to several configurations of DNA to reveal the consequences of mechanical stepping on taut chromatin under tension versus loop extrusion on single-tethered, floppy chromatin substrates. These simulations provide testable hypotheses for condensin and other DNA-based motors functioning along interphase chromosomes. Our model reveals a novel mechanism for condensin enrichment in the pericentromeric region of mitotic chromosomes. Increased condensin dwell time at centromeres results in a high density of pericentric loops that in turn provide substrate for additional condensin.
Liberating cohesin from cohesion
Creators: name: Bloom, K.
Publisher: name: Cold Spring Harbor Laboratory Press
Year: 2017

description: Cohesin was identified through its major role in holding sister chromatids together. We are learning through analysis of cohesin and other members of the protein family (SMC [structural maintenance of chromosomes]) and their regulators that these ring complexes contribute to chromosome organization and dynamics throughout the cell cycle. We need to consider not only how ring complexes are regulated but how they interact with their fluctuating chromatin substrate.
Single Rh adatoms stabilized on α-Fe2O3(1-102) by co-adsorbed water
Creators: name: Kraushofer, Florian
name: Haager, Lena
name: Eder, Moritz
name: Rafsanjani-Abbasi, Ali
name: Jakub, Zdeněk
name: Franceschi, Giada
name: Riva, Michele
name: Meier, Matthias
name: Schmid, Michael
name: Diebold, Ulrike
name: Parkinson, Gareth S.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Oxide-supported single-atom catalysts are commonly modelled as a metal atom substituting surface cation sites in a low-index surface. Adatoms with dangling bonds will inevitably coordinate molecules from the gas phase, and adsorbates such as water can affect both stability and catalytic activity. Here, we use scanning tunneling microscopy (STM), noncontact atomic force microscopy (ncAFM), and x-ray photoelectron spectroscopy (XPS) to show that high densities of single Rh adatoms are stabilized on alpha-Fe2O3(1-102) in the presence of 2x10^(-8) mbar of water at room temperature, in marked contrast to the rapid sintering observed under UHV conditions. Annealing to 50 °C in UHV desorbs all water from the substrate leaving only the OH groups coordinated to Rh, and high-resolution ncAFM images provide a direct view into the internal structure. We provide direct evidence of the importance of OH ligands in the stability of single atoms, and argue that their presence should be assumed when modelling SAC systems.
ПОЭЗИЯ - СИЛА ПРОТИВ ВОЙНЫ (НА МАТЕРИАЛЕ ХАКАССКОЙ ПОЭЗИИ)
Creators: name: ТАСКАРАКОВА Н.Н.
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: ПОЭЗИЯ
ВОЕННАЯ ТЕМА
ФОЛЬКЛОРНАЯ ТРАДИЦИЯ
СТИХИ-НАКАЗЫ
POETRY
MILITARY THEME
FOLKLORE TRADITION
VERSES-PUNISHMENTS

description: Рассматривается поэзия периода Великой Отечественной войны. Анализируются, в основном, произведения хакасских поэтов: Н. Доможакова, И. Котюшева и др. Проводятся параллели с другими тюркскими литературами (тувинской, татарской, якутской и т.д). Основное внимание уделяется стихотворениям призывного, агитационного характера. Подчеркивается мысль поэзия имеет большую духовную силу.The poetry of the period of the Great Patriotic War is considered. Basically, the works of Khakassian poets are analyzed: N. Domozhakova, I. Kotyushev, etc. Parallels are drawn with other Turkic literature (Tuvan, Tatar, Yakut, etc.). The main attention is paid to poems of draft, propaganda nature. The idea is emphasized poetry has great spiritual power.
ФУНКЦИОНАЛЬНО-СЕМАНТИЧЕСКИЕ ОСОБЕННОСТИ ХАКАССКИХ ГЛАГОЛОВ СО ЗНАЧЕНИЕМ РЕЧЕВОГО ВЗАИМОДЕЙСТВИЯ И КОНТАКТА
Creators: name: ЧЕРТЫКОВА М.Д.
name: КАКСИН Ч.А.
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: ГЛАГОЛЫ СО ЗНАЧЕНИЕМ РЕЧЕВОГО ВЗАИМОДЕЙСТВИЯ И КОНТАКТА
ОБЩЕНИЕ
СЕМАНТИКА
ФУНКЦИОНИРОВАНИЕ
ДВОЙСТВЕННОСТЬ
ХАКАССКИЙ ЯЗЫК
VERBS WITH THE MEANING OF SPEECH INTERACTION AND CONTACT
COMMUNICATION
SEMANTICS
FUNCTIONING
DUALITY
KHAKASS LANGUAGE

description: Статья посвящена выявлению и функционально-семантическому описанию глаголов речевого взаимодействия и контакта в хакасском языке. На основе общности семы взаимности данные глаголы составляют одну из подгрупп в лексико-семантической группе глаголов говорения. Всего мы насчитываем 17 глаголов со значением взаимного общения. В ходе анализа установлено, что эти глаголы обладают двойственностью семантики, которая утверждается формально-грамматическими и семантическими показателями. Принцип семантической двойственности обусловлен реализуемыми ими способами общения: а) обмениваться с кем-л. мыслями, мнениями; б) вести с кем-л. разговор, беседу. Данные глаголы могут также выражать однонаправленный процесс речи, если в конструкции присутствует позиция «перед кем».The article is devoted to the identification and functional-semantic description of verbs of verbal interaction and contact in the Khakass language. Based on the generality of the seme of reciprocity, these verbs form one of the subgroups in the lexical-semantic group of speaking verbs. In total, we have 17 verbs with the meaning of mutual communication. The analysis found that these verbs have the duality of semantics, which is confirmed by formal-grammatical and semantic indicators. The principle of semantic duality is due to the means of communication that they realize: a) to exchange with smb. thoughts, opinions; b) carry on with conversation, conversation. These verbs can also express a unidirectional process of speech, if the design has a «before whom» position.
Black Holes in 4D Einstein-Gauss-Bonnet gravity with exponential electrodynamics
Creators: name: Paul, Prosenjit
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We investigate $4D$ Einstein-Gauss-bonnet gravity coupled to exponential electrodynamics in AdS background and found a static, spherically symmetric exact black hole solution. The horizon structure of black hole is discussed. Treating the cosmological constant as pressure, we drive first law of black hole thermodynamics in extended phase space. We compute the electrostatic potential and vacuum polarization of the black hole. To study local thermodynamical stability specific heat of the black hole is computed. Finally, we study Helmholtz free energy to analyse the global stability of black holes.
THE ROLE OF SIALIDASE NEU3 IN THE CARDIAC RESPONSE TO ISCHEMIA AND REPERFUSION INJURY
Creators: name: CANALI, MARIA ELENA
Publisher: name: Universit� degli Studi di Milano
Year: 2019

description: THE ROLE OF SIALIDASE NEU3 IN THE CARDIAC RESPONSE TO ISCHEMIA AND REPERFUSION INJURY Maria Elena Canalia,b, Marco Piccolia, Andrea Ghiroldia, Federica Cirilloa, and Luigi Anastasiaa,b a Laboratorio delle cellule staminali e ingegneria tissutale, IRCCS Policlinico San Donato, piazza Malan 2, 20097 San Donato Milanese, Milano, Italia; email: maria.canali@unimi.it b Dipartimento di Scienze Biomediche per la Salute, Universit� degli Studi di Milano, via Luigi Mangiagalli 31, 20133, Milano, Italia; L'infarto miocardico acuto (AMI) � una delle cause pi� comuni di morte in tutto il mondo. Le strategie di riperfusione sono le procedure salvavita pi� utilizzate per il trattamento dell'AMI, ma inducono anche l?insorgenza del cosiddetto danno da ischemia e riperfusione (IRI), con conseguente sviluppo di insufficienza cardiaca. Molti sforzi sono stati fatti per chiarire i meccanismi molecolari coinvolti nell'IRI e, in questo contesto, l'attivazione delle chinasi pro-sopravvivenza, nonch� il fattore inducibile dell'ipossia (HIF-1?), sono stati riconosciuti come regolatori chiave della risposta cellulare all'IRI. Al riguardo, abbiamo recentemente identificato un nuovo meccanismo di attivazione dei HIF-1? mediato dalla sialidasi NEU3, che � stato in grado di aumentare la resistenza delle cellule muscolari allo stress ipossico. Pertanto, lo scopo di questo studio � stato quello di valutare se NEU3 potesse avere un ruolo anche nel contrastare il danno da ischemia e riperfusione. A tal fine, NEU3 � stato sovraespresso nei cardiomioblasti di ratto H9C2, i quali sono stati trasfettati con un plasmide contenete la sequenza di NEU3 per sovraesprimere l'enzima. Sorprendentemente, le cellule NEU3 overesprimenti hanno mostrato un tasso di proliferazione e sopravvivenza, cos� come un tasso di attivazione di HIF-1? e delle chinasi pro-sopravvivenza Akt ed Erk significativamente maggiore rispetto ai controlli a seguito dell'IRI. � interessante notare che il trattamento con gli inibitori di Akt ed Erk, nonch� con gli inibitori di NEU3 (DANA e LR332) ha completamente annullato gli effetti benefici mediati dall'enzima, supportando il possibile coinvolgimento della sialidasi nel contrastare l'IRI attraverso l'attivazione delle chinasi pro-sopravvivenza. Inoltre, abbiamo studiato anche il possibile coinvolgimento di NEU3 nella regolazione del processo di fibrosi cardiaca, una risposta fisiologica alla lesione del tessuto cardiaco, caratterizzata dalla deposizione di proteine della matrice extracellulare da parte di miofibroblasti attivati. I nostri studi hanno dimostrato che la sovraespressione della sialidasi NEU3 � sufficiente per ridurre il transdifferenziamento dei fibroblasti a miofibroblasti attraverso la diminuzione del contenuto cellulare di GM3.
High-Dimensional Methods for Timely and Interpretable Economic Statistics
Creators: name: Mosley, Luke
Publisher: name: Lancaster University
Year: 2023
Subjects: economic statistics
Lasso
temporal disaggregation
nowcasting
high dimensional statistics

description: The need for a timely and detailed measure of the economy has become increasingly important in recent years due to sudden periods of economic growth and decline. It has become imperative for policymakers and practitioners to accurately capture short-term dynamics and trajectories as we emerge from shocks. However, relying on traditional survey-centric economic indicators presents challenges, as they often lack granularity and are published with significant delays. For this reason, National Statistics Institutes, such as the UK's Office for National Statistics, are undergoing a transformation by incorporating administrative and alternative data-sources as key components of their statistical frameworks. These data sources offer several benefits, including timeliness, cost-effectiveness, reliability, and comprehensive coverage of economic processes. While a sense of awareness for these new data-sources is being established, the statistical methodology to calibrate insights from these sources remains under-developed. This thesis develops new methodology for producing timely and interpretable economic statistics. Specifically, it proposes novel techniques to address the crucial tasks of temporal disaggregation and nowcasting when dealing with large volumes of high-dimensional data. The frameworks developed in this research leverage the growing body of literature on sparsity-inducing regularisers, allowing for interpretable measures of relevant data-sources. Acknowledging the importance of reproducibility, the work presented is developed into R packages, and a wide range of case studies are extensively covered to showcase applicability of the proposed methodologies.
title: Die Utopie der Verantwortungszuschreibung in der Mensch-Maschine-Interaktion
Creators: name: Liebetreu, Theresia
Year: 2023

description: In Anbetracht der rasanten Weiterentwicklung von künstlicher Intelligenz, artifiziellen Systemen und Robotern rückt die Frage der Verantwortungszuschreibung insbesondere im Kontext der Mensch-Maschine-Interaktion immer mehr in den Fokus gesellschaftlichen Interesses. Trotz des Bestehens diverser Konzepte, die die Zuschreibung von Verantwortung im zwischenmenschlichen Bereich regeln und strukturieren, ergibt sich in der Anwendung ebendieser Konzepte auf nicht-menschliche Instanzen eine Problematik, die dringend zu bearbeiten ist. Dieser Arbeit liegt die These zugrunde, die Verantwortungszuschreibung in der Mensch-Maschine-Interaktion sei grundsätzlich utopisch. Um diese These zu evaluieren, werden unterschiedliche Verantwortungskonzepte einander gegenübergestellt und auf die Möglichkeit ihrer Anwendung im Bereich der Mensch-Maschine-Interaktion geprüft. Auch die Verortung artifizieller Systeme als moralische Handlungssubjekte oder moralische Handlungsobjekte wird in diesem Kontext berücksichtigt. Die philosophische Auseinandersetzung zeigt mittels einer kritischen Reflexion theoretischer Konzepte sowie anhand der Betrachtung einer Reihe an Beispielen aus unterschiedlichen Bereichen der Roboterethik, dass in Hinblick auf Maschinen und Roboter eine Zuschreibung von Verantwortung tatsächlich utopisch ist. Diese Erkenntnis kann einerseits im Philosophieunterricht der Sekundarstufe II genutzt werden, um Schüler*innen für die Probleme in der Mensch-Maschine-Interaktion empfänglich zu machen. Andererseits dient die im Rahmen dieser Arbeit detailliert dargelegte Utopie der Verantwortungszuschreibung als Basis für weitere wissenschaftliche Forschung und Entwicklung neuer Konzepte.
Bi-objective risk-averse facility location using a subset-based representation of the conditional value-at-risk
Creators: name: Nazemi, Najmesadat
name: Parragh, Sophie N.
name: Gutjahr, Walter J.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Optimization and Control (math.OC)
subject: Discrete Mathematics (cs.DM)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences

description: For many real-world decision-making problems subject to uncertainty, it may be essential to deal with multiple and often conflicting objectives while taking the decision-makers' risk preferences into account. Conditional value-at-risk (CVaR) is a widely applied risk measure to address risk-averseness of the decision-makers. In this paper, we use the subset-based polyhedral representation of the CVaR to reformulate the bi-objective two-stage stochastic facility location problem presented in Nazemi et al. (2021). We propose an approximate cutting-plane method to deal with this more computationally challenging subset-based formulation. Then, the cutting plane method is embedded into the epsilon-constraint method, the balanced-box method, and a recently developed matheuristic method to address the bi-objective nature of the problem. Our computational results show the effectiveness of the proposed method. Finally, we discuss how incorporating an approximation of the subset-based polyhedral formulation affects the obtained solutions.
description: arXiv admin note: substantial text overlap with arXiv:2007.07767
Discussion of "On the Birnbaum Argument for the Strong Likelihood Principle"
Creators: name: Hannig, Jan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: In this discussion we demonstrate that fiducial distributions provide a natural example of an inference paradigm that does not obey Strong Likelihood Principle while still satisfying the Weak Conditionality Principle. [arXiv:1302.7021]
description: Published in at http://dx.doi.org/10.1214/14-STS474 the Statistical Science (http://www.imstat.org/sts/) by the Institute of Mathematical Statistics (http://www.imstat.org)
(503240) Frank T.W. West
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Plethons Tugendlehre ausgehend von seiner Schrift "De virtutibus" im Vergleich zum Tugendkonzept bei Platon und Aristoteles
Creators: name: Unterlechner, Michael Anton
Year: 2023

description: Was ist ein tugendhaftes Leben? Diese Frage ist nur schwer zu beantworten, da wir alle einen anderen Tugendbegriff haben: Für den einen kann dies schlichtweg bedeuten, keine Verbrechen zu begehen, für den anderen, sich in den Dienst der Gesellschaft zu stellen, verschiedene wohltätige Organisation zu unterstützen etc. Umso wichtiger ist es, den Blick in die Antike und zum Ursprung der philosophischen Behandlung dieses Themas zu richten, denn der Tugendbegriff hat sich in den letzten Jahrhunderten sehr gewandelt. Dabei kann aufgrund der schier nicht enden wollenden Literatur zu diesem Thema kein Gesamtüberblick bis in die Moderne gegeben werden. Das Hauptaugenmerk der vorliegenden Arbeit liegt auf den Tugendkonzepten Aristoteles’, Platons und Plethons. Letzterer (dessen Namen leider immer mehr in Vergessenheit gerät) wandelte als Neuplatoniker auf Platons Pfaden, weshalb ein Vergleich mit seinem Idol äußerst spannend und ertragreich ist. So sehr er Platon huldigte, so sehr lehnte er die Lehre des Aristoteles ab. Doch nicht nur deshalb ist Plethon eine solch interessante Persönlichkeit, sondern auch wegen seines Plans, eine „Universalreligion“ zu etablieren. Dieser Wunsch war im byzantinischen Reich des 15. Jahrhunderts keinesfalls Usus und brachte Plethon nicht nur viel Anerkennung, sondern auch Schimpf und Schande ein. Für Plethon bilden die verschiedenen Tugenden die Grundlage, um sich Gott (interessanterweise Zeus!) zu nähern. Plethons Schrift Über die Tugenden stellt den Ausgangspunkt der Recherche dar. Diese wird in Form einer sich nahe am Originaltext orientierenden Zusammenfassung wiedergegeben, um dem Leser die parallele Lektüre von Original und Übersetzung zu erleichtern. Ausgehend von dieser bis heute relevanten Schrift werden die antiken, die weltlichen und christlichen Kardinaltugenden (mit kurzen Ausblicken auf verschiedene Epochen und Religionen) behandelt. Um nicht in einer Flut von Namen den Überblick zu verlieren, beziehe ich mich neben den drei eben genannten großen Denkern lediglich auf einige weitere Autoren. Anhand ausgewählter Werke wird der Tugendbegriff beleuchtet und daraus schlussendlich der Versuch generiert werden, eine Synopse dieser Tugendkonzepte zu bilden. Dass auch die ausgewählten Werke nur einen kleinen Eindruck dieses äußerst umfangreichen Themas vermitteln können, liegt ebenfalls auf der Hand. Die vorliegende Arbeit soll jedoch dazu anregen, sich weiter mit den verschiedenen Tugendkonzepten zu beschäftigen und vielleicht auch im Alltag etwas die Sinne hinsichtlich unseres zwischenmenschlichen Umgangs miteinander zu schärfen. Doch was ist nun unter Tugend zu verstehen? Tugend lässt sich vielleicht am besten unter Bezugnahme auf Platons Politeia so zusammenfassen: Wer anderen hilft (oder diesen zumindest nicht schadet), macht schon viel richtig.
title: Entwicklung einer Intervention zur Verbesserung der psychischen Gesundheitskompetenz von Lehrpersonen der Sekundarstufe in Österreich
Creators: name: Pöllmann, Hannah
Year: 2023

description: Hintergrund. In einem gemeinsamen Masterarbeitsprojekt wurde ein wissenschaftskommunikatorisches Infoheft entwickelt und überprüft. Dieses beinhaltet Wissen und Handlungsempfehlungen für Lehrpersonen der Sekundarstufe zum Thema psychische Gesundheit und Krankheit bei Schüler*innen. Methodik. Überprüft wurde dieses als Intervention in einem Ein-Gruppen-Prä-Posttest-Design. Hierfür wurden zwei Konstrukte, Selbstwirksamkeit und psychische Gesundheitskompetenz von Lehrpersonen (jeweils in Bezug auf den Umgang mit psychischer Gesundheit und Krankheit bei Schüler*innen), vor und nach dem Lesen des Infohefts mittels Fragebogen erhoben. Angenommen wurde eine Verbesserung der Werte beider Konstrukte nach dem Lesen. Die vorliegende Arbeit beschäftigt sich mit den Hintergründen und Ergebnissen zur psychischen Gesundheitskompetenz. Als Versuchspersonen dienten praxiserfahrene Lehramtsstudierende. Ergebnisse. Zwei von drei Aspekten der psychischen Gesundheitskompetenz (1. die Fähigkeiten im Umgang mit psychischen Problemen bei Schüler*innen, sowie 2. das Finden, Verstehen und Beurteilen von Informationen zu psychischen Problemen von Schüler*innen) zeigten statistisch signifikant verbesserte Werte nach der Intervention. Schlussfolgerung. Die vorliegende Studie kann als Beleg dafür dienen, dass niederschwellige wissenschaftskommunikatorische Interventionen wie ein Infoheft Verbesserungen in der psychischen Gesundheitskompetenz von Lehrpersonen in Bezug auf ihre Schüler*innen zur Folge haben können.
description: Background. In a joint masters’ thesis project, a science communication product in the form of an information booklet was developed and evaluated. It contains knowledge and recommendations for action for secondary school teachers on the topic of mental health and illness in students. Methods. The booklet was evaluated using a One-Group Pretest-Posttestdesign. To do so, two constructs, namely self-efficacy and mental health literacy of teachers (each regarding handling the topic of mental health and illness in their students) were conducted via questionnaires before and after reading the booklet. An improvement in both constructs was expected. The following thesis discusses the background and results for participants’ mental health literacy. The sample comprised of student teachers with teaching experience. Results. Two out of three aspects of participants’ mental health literacy (namely 1. abilities in handling mental health concerns in students, and 2. Finding, understanding and judging information on the topic) showed statistically significant improvement after the intervention. Conclusion. It is therefore concluded that low-threshold science communication interventions such as an information booklet can lead to at least some improvement in (student) teachers’ mental health literacy regarding their students.
КОНЦЕПТ «НЕБО» В РУССКОМ И КИТАЙСКОМ ЯЗЫКАХ (НА МАТЕРИАЛЕ ФРАЗЕОЛОГИЗМОВ)
Creators: name: ЯН СЮАНЬ
name: ЛО СЯОСЯ
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: КОНЦЕПТ «НЕБО»
ФРАЗЕОЛОГИЗМ
РАЗЛИЧИЕ
РУССКАЯ И КИТАЙСКАЯ КУЛЬТУРЫ
CONCEPT “SKY”
PHRASEOLOGICAL UNIT
DIFFERENCE
RUSSIAN AND CHINESE CULTURE

description: Лингвокультурология характеризуется интересом к проблемам взаимосвязи языка и культуры. Особенно актуально исследование культурных концептов и их воплощения в разных языках. В нашей работе рассматривается концепт «небо» на материале русских и китайских фразеологизмов и выявляться национально-культурная специфика двух культур.Linguoculturology is characterized by interest in the problems of the relationship of language and culture. The study of cultural concepts and their implementation in different languages is especially relevant. In our work, the concept of “heaven” is considered on the basis of Russian and Chinese phraseological units and the national-cultural specificity of the two cultures is revealed.
Tension sensors reveal how the kinetochore shares its load
Creators: name: Salmon, E.D.
name: Bloom, K.
Publisher: name: John Wiley and Sons Inc.
Year: 2017

description: At metaphase in mitotic cells, pulling forces at the kinetochore-microtubule interface create tension by stretching the centromeric chromatin between oppositely oriented sister kinetochores. This tension is important for stabilizing the end-on kinetochore microtubule attachment required for proper bi-orientation of sister chromosomes as well as for satisfaction of the Spindle Assembly Checkpoint and entry into anaphase. How force is coupled by proteins to kinetochore microtubules and resisted by centromere stretch is becoming better understood as many of the proteins involved have been identified. Recent application of genetically encoded fluorescent tension sensors within the mechanical linkage between the centromere and kinetochore microtubules are beginning to reveal – from live cell assays – protein specific contributions that are functionally important.
Centromere Structure and Function
Creators: name: Costanzo, V.
name: Bloom, K.
Publisher: name: NLM (Medline)
Year: 2017

description: The centromere is the genetic locus that specifies the site of kinetochore assembly, where the chromosome will attach to the kinetochore microtubule. The pericentromere is the physical region responsible for the geometry of bi-oriented sister kinetochores in metaphase. In budding yeast the 125 bp point centromere is sufficient to specify kinetochore assembly. The flanking region is enriched (3X) in cohesin and condensin relative to the remaining chromosome arms. The enrichment spans about 30-50 kb around each centromere. We refer to the flanking chromatin as the pericentromere in yeast. In mammals, a 5-10 Mb region dictates where the kinetochore is built. The kinetochore interacts with a very small fraction of DNA on the surface of the centromeric region. The remainder of the centromere lies between the sister kinetochores. This is typically called centromere chromatin. The chromatin sites that directly interface to microtubules cannot be identified due to the repeated sequence within the mammalian centromere. However in both yeast and mammals, the total amount of DNA between the sites of microtubule attachment in metaphase is highly conserved. In yeast the 16 chromosomes are clustered into a 250 nm diameter region, and 800 kb (16 × 50 kb) or ~1 Mb of DNA lies between sister kinetochores. In mammals, 5-10 Mb lies between sister kinetochores. In both organisms the sister kinetochores are separated by about 1 μm. Thus, centromeres of different organisms differ in how they specify kinetochore assembly, but there may be important centromere chromatin functions that are conserved throughout phylogeny. Recently, centromeric chromatin has been reconstituted in vitro using alpha satellite DNA revealing unexpected features of centromeric DNA organization, replication, and response to stress. We will focus on the conserved features of centromere in this review.
Fête patronale de la saint Marcel, psaume "Deus in adjutorium" chanté par un choeur mixte pour le début de l'office de complies
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2024

Abstract
(503241) John Charles Long
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
CO oxidation by Pt2/Fe3O4: metastable dimer and support configurations facilitate lattice oxygen extraction
Creators: name: Meier, Matthias
name: Hulva, Jan
name: Jakub, Zdenek
name: Kraushofer, Florian
name: Bobić, Mislav
name: Bliem, Roland
name: Setvin, Martin
name: Schmid, Michael
name: Diebold, Ulrike
name: Franchini, Cesare
name: Parkinson, Gareth S.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Heterogeneous catalysts based on sub-nanometer metal clusters often exhibit strongly size-dependent properties, and the addition or removal of a single atom can make all the difference. Identifying the most active species and deciphering the reaction mechanism is extremely difficult, however, because it is often not clear how the catalyst evolves in operando. Here, we utilize a combination of atomically resolved scanning probe microscopies, spectroscopic techniques, and density functional theory (DFT)-based calculations to study CO oxidation by a model Pt/Fe3O4(001) single-atom catalyst. We demonstrate that (PtCO)2 dimers, formed dynamically through the agglomeration of mobile Pt-carbonyl species, catalyse a reaction involving the oxide support to form CO2. Pt2 dimers produce one CO2 molecule before falling apart into two adatoms, releasing the second CO. Interestingly, Olattice extraction only becomes facile when both the Pt-dimer and the Fe3O4 support can access metastable configurations, suggesting that substantial, concerted rearrangements of both cluster and support must be considered for reactions occurring at elevated temperature.
ВЛИЯНИЕ ИНОСТРАННОГО КАПИТАЛА НА ДЕЯТЕЛЬНОСТЬ РОССИЙСКИХ ПРЕДПРИЯТИЙ
Creators: name: АККАЕВ А.А.
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: ЭКОНОМИКА
ИНВЕСТИЦИИ
ПРЯМЫЕ ИНОСТРАННЫЕ ИНВЕСТИЦИИ
ВЕНЧУРНЫЙ РЫНОК
ДЕЛОВАЯ АКТИВНОСТЬ
ECONOMY
INVESTMENT
FOREIGN DIRECT INVESTMENT
VENTURE MARKET
BUSINESS ACTIVITY

description: В данной статье проведен анализ влияния иностранного капитала на деятельность российский предприятий. Рассмотрена деятельность таких инстранных компаний, как «Nestlé» и «Renault» на территории Российской Федерации. Проанализированы разные сценарии взаимодействия отечественных предприятий с иностранными компаниями. Рассмотрено влияние иностранного капитала на российский венчурный рынок. Сформированы выводы о положительном влиянии иностранного капитала на экономику РФ, а также проанализированы факторы, которые мешают увеличению финансового потока из зарубежных государств.The analysis of the influence of foreign capital on the activities of Russian enterprises. The activities of such foreign companies as Nestlé and Renault in the Russian Federation are considered. Different scenarios of the interaction of domestic enterprises with foreign companies are analyzed. The influence of foreign capital on the Russian venture market is considered. Conclusions are drawn on the positive impact of foreign capital on the Russian economy, and factors that impede the increase in financial flow from foreign countries are analyzed.
БАНКРОТСТВО В БАНКОВСКОМ СЕКТОРЕ
Creators: name: БАЛАШЕВ Н.Б.
name: ИСТОМИНА Е.А.
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: БАНКОВСКИЙ СЕКТОР РФ
БАНКРОТСТВО
ЦЕНТРАЛЬНЫЙ БАНК РФ
КРЕДИТНАЯ ОРГАНИЗАЦИЯ
ФИНАНСОВОЕ ОЗДОРОВЛЕНИЕ
BANKING SECTOR OF THE RUSSIAN FEDERATION
BANKRUPTCY
CENTRAL BANK OF THE RUSSIAN FEDERATION
CREDIT ORGANIZATION
FINANCIAL RECOVERY

description: Цель данной работы определение эффективности влияния Центрального банка РФ на динамику количества кредитных организаций. В работе проведен анализ несостоятельности (банкротства) кредитных организаций в РФ, отражена динамика сокращения кредитных организаций в период 2001-2018 гг., отдельно рассмотрен отзыв лицензий кредитных организаций в рассматриваемом периоде и в 2019 году, также отражены внутренние и внешние причины банкротства. Рассмотрены правовые аспекты и основные способы предотвращения банкротства в российском законодательстве.The purpose of this work is to determine the effectiveness of the influence of the Central Bank of the Russian Federation on the dynamics of the number of credit institutions. The paper analyzes the insolvency (bankruptcy) of credit organizations in the Russian Federation, reflects the dynamics of reduction of credit organizations in the period 2001-2018, separately considers the revocation of licenses of credit organizations in the period under review and in 2019, and also reflects internal and external causes of bankruptcy. Legal aspects and main ways to prevent bankruptcy in Russian legislation are considered.
Book of abstracts of the ICPP Satellite Event: High-throughput sequencing in plant virology: from discovery to diagnostics
Creators: name: Ravnikar, Maja
name: Kutnjak Denis
name: Giovani, Baldissera
name: Fox, Adrian
name: Botermans, Marleen
name: Oplaat, Carla
name: Mollov, Dimitre
Publisher: name: Zenodo
Year: 2023
Subjects: ICPP, plant health, virology, diagnostics, epidemiology, high-throughput sequencing, HTS, next generation sequencing, NGS

description: High-throughput sequencing (HTS) technologies have revolutionized plant virus research and diagnostics by accelerating the discovery of new viruses and by providing a sensitive untargeted approach for the detection of viruses. The latter, together with high data-generation potential of HTS, enables discovery of new and emerging viruses from diverse hosts, archived or ancient samples, and untargeted virus detection in diverse matrices, as well as research on a broad range of topics, such as plant virus epidemiology, diversity, and evolution. Many new plant virus discoveries, increased availability of sequence data, and a lagging biological characterization of HTS-based findings call for a broad consideration on harmonization of sequencing and data analysis approaches, as well as the interpretation of the results from the scientific and regulatory perspective. During this satellite meeting, different aspects of applying HTS in plant virology will be addressed and discussed. Topics will include: discovery and detection of new and emerging viruses; virus diversity, epidemiology, and evolution studies; development of virus detection and identification protocols and validation of HTS-based tests for plant virus diagnostics.
(503242) George Oliver Long
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
FBW7 loss promotes chromosomal instability and tumorigenesis via cyclin E1/CDK2–mediated phosphorylation of CENP-A
Creators: name: Wei, W.
name: Yu, Z.
name: Zhang, Q.
name: Hu, L.
name: Zhai, B.
name: Kuroda, T.S.
name: Wan, L.
name: Zhuang, M.
name: Bloom, K.
name: Karpen, G.H.
name: Zhang, W.
name: Fry, C.J.
name: Li, G.
name: Takada, M.
name: Gao, D.
name: Suzuki, A.
name: Inuzuka, H.
Publisher: name: American Association for Cancer Research Inc.
Year: 2017

description: The centromere regulates proper chromosome segregation, and its dysfunction is implicated in chromosomal instability (CIN). However, relatively little is known about how centromere dysfunction occurs in cancer. Here, we define the consequences of phosphorylation by cyclin E1/CDK2 on a conserved Ser18 residue of centromere-associated protein CENPA, an essential histone H3 variant that specifies centromere identity. Ser18 hyperphosphorylation in cells occurred upon loss of FBW7, a tumor suppressor whose inactivation leads to CIN. This event on CENP-A reduced its centromeric localization, increased CIN, and promoted anchorage-independent growth and xenograft tumor formation. Overall, our results revealed a pathway that cyclin E1/CDK2 activation coupled with FBW7 loss promotes CIN and tumor progression via CENP-A–mediated centromere dysfunction.
On Computing the Translations Norm in the Epipolar Graph
Creators: name: Arrigoni, Federica
name: Rossi, Beatrice
name: Fusiello, Andrea
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: This paper deals with the problem of recovering the unknown norm of relative translations between cameras based on the knowledge of relative rotations and translation directions. We provide theoretical conditions for the solvability of such a problem, and we propose a two-stage method to solve it. First, a cycle basis for the epipolar graph is computed, then all the scaling factors are recovered simultaneously by solving a homogeneous linear system. We demonstrate the accuracy of our solution by means of synthetic and real experiments.
description: Accepted at 3DV 2015
Loggi: Treinamento Localizado em Automatização de Teste de Software em Ambiente Empresarial
Creators: name: Vincenzi, Auri
Publisher: name: Zenodo
Year: 2020

description: Apresentação do artigo Loggi: Treinamento Localizado em Automatização de Teste de Software em Ambiente Empresarial para a trilha de Indústria do CBSoft'2020.
ФОРМИРОВАНИЕ ДИВЕРСИФИКАЦИОННОЙ СТРАТЕГИИ ПРЕДПРИЯТИЯ ОБОРОННО-ПРОМЫШЛЕННОГО КОМПЛЕКСА
Creators: name: БАТЬКОВСКИЙ А.М.
name: ФОМИНА А.В.
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: ДИВЕРСИФИКАЦИОННАЯ СТРАТЕГИЯ
ПРЕДПРИЯТИЯ
ОБОРОННО-ПРОМЫШЛЕННЫЙ КОМПЛЕКС
МЕРОПРИЯТИЯ
ИНСТРУМЕНТАРИЙ
DIVERSIFICATION STRATEGY
ENTERPRISES
MILITARY-INDUSTRIAL COMPLEX
MEASURES
TOOLS

description: В статье развиты существующие научные направления в рассматриваемой предметной области. На основе результатов исследования процесса диверсификации военного производства разработан прикладной экономико-математический инструментарий оптимизации важнейших показателей, характеризующих данный процесс на предприятиях оборонно-промышленного комплекса. Усовершенствованы ранее применяемые критерии и показатели, используемые при решении рассматриваемых управленческих задач. Разработанные алгоритмы согласованы между собой, адекватны исследуемому процессу и объективно отражают его закономерности. В совокупности они образуют инструментарий формирования диверсификационной стратегии предприятия оборонно-промышленного комплекса.The article develops the existing scientific directions in the subject area under study. Based on the results of the study of the process of military production diversification, an applied economic and mathematical tool for optimizing the most important indicators that characterize this process at the enterprises of the military-industrial complex has been developed. The previously applied criteria and indicators used in solving the management tasks under consideration have been improved. The developed algorithms are consistent with each other, are adequate to the studied process and objectively reflect its regularities. Together, they form a tool for forming a diversification strategy for the defense industry enterprise.
ВЛИЯНИЕ ФИНАНСОВЫХ КРИЗИСОВ НА ЭКОНОМИКУ РОССИЙСКОЙ ФЕДЕРАЦИИ: ТЕНДЕНЦИИ И ПЕРСПЕКТИВЫ
Creators: name: БЕЛЬСКАЯ А.И.
name: СЫЧЕВА М.С.
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: ФИНАНСОВЫЕ КРИЗИСЫ
ЦЕНЫ НА ЭНЕРГОНОСИТЕЛИ
РОССИЙСКАЯ ЭКОНОМИКА
ФИНАНСОВАЯ СИСТЕМА
СТАГНАЦИЯ
FINANCIAL CRISES
ENERGY PRICES
ECONOMY
FINANCIAL SYSTEM
STAGNATION

description: В статье рассматривается влияние финансовых кризисов на экономики различных стран. Цель исследования выявить общие показатели, на которые оказывает воздействие рецессия, и проанализировать ситуацию, возникшую в 2020 году в мире. Использованы методы ретроспекция, аналитического, статистического и графического исследования. В работе проанализированы мировой кризис 2008-2009 годов и кризис 2014-2015 гг. в России, обозначены причины их возникновения, изучены основные изменения макроэкономических показателей, таких как объем ВВП, цены на нефть, валютный курс, безработица, инфляция, золотовалютные резервы. Результатом является определение слабого места Российской Федерации, по которому ударили все вышеперечисленные коллапсы экономики. Сделан вывод о том, что экономика по своей природе развивается циклически, следовательно, финансовая система стоит на гране очередного кризиса.The article gives details about the impact of financial crises on the economies of different countries. The purpose of the article is to identify the general indicators, which are affected by the recession, and to analyze the situation that has emerged in the world in 2020. Methods of retrospection, analytical, statistical and graphical research were used. The article analyzes the global crisis of 2008-2009 and the crisis of 2014-2015 in Russia, identifies the causes of their emergence and studies the main changes in macroeconomic indicators, such as GDP, oil prices, the exchange rate, unemployment, inflation, and foreign exchange reserves. The result is the identification of the weak point of the Russian Federation, which was hit by all the above-mentioned financial crises. It is concluded that the economic cycle is a natural form of economic development, therefore, the financial system is on the verge of another crisis.
(503244) Thomas Hilton Fuller
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Characterizing the VPN Ecosystem in the Wild
Creators: name: Maghsoudlou, Aniss
name: Vermeulen, Lukas
name: Poese, Ingmar
name: Gasser, Oliver
Publisher: name: arXiv
Year: 2023
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: With the shift to working remotely after the COVID-19 pandemic, the use of Virtual Private Networks (VPNs) around the world has nearly doubled. Therefore, measuring the traffic and security aspects of the VPN ecosystem is more important now than ever. It is, however, challenging to detect and characterize VPN traffic since some VPN protocols use the same port number as web traffic and port-based traffic classification will not help. VPN users are also concerned about the vulnerabilities of their VPN connections due to privacy issues. In this paper, we aim at detecting and characterizing VPN servers in the wild, which facilitates detecting the VPN traffic. To this end, we perform Internet-wide active measurements to find VPN servers in the wild, and characterize them based on their vulnerabilities, certificates, locations, and fingerprinting. We find 9.8M VPN servers distributed around the world using OpenVPN, SSTP, PPTP, and IPsec, and analyze their vulnerability. We find SSTP to be the most vulnerable protocol with more than 90% of detected servers being vulnerable to TLS downgrade attacks. Of all the servers that respond to our VPN probes, 2% also respond to HTTP probes and therefore are classified as Web servers. We apply our list of VPN servers to the traffic from a large European ISP and observe that 2.6% of all traffic is related to these VPN servers.
description: Code and data availabe at https://vpnecosystem.github.io/
РАСХОДЫ НА ОБОРОНУ В МИРЕ: НАПРАВЛЕНИЕ НА СОКРАЩЕНИЕ
Creators: name: БОЙКОВА А.В.
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: ОБОРОНА
БЮДЖЕТ
РАСХОДЫ НА НАЦИОНАЛЬНУЮ ОБОРОНУ
МИРОВАЯ ЭКОНОМИКА
ПАНДЕМИЯ КОРОНАВИРУСА
DEFENSE
BUDGET
NATIONAL DEFENSE SPENDING
WORLD ECONOMY
CORONAVIRUS PANDEMIC

description: Сочетание пандемии, экономических последствий карантинных мер, введенных для ее сдерживания, на фоне войны цен на нефть привели к необходимости кардинального пересмотра состояния государственных финансов. С одной стороны, сейчас, когда правительство вынуждено искать финансовые ресурсы на многомилионные выплаты в целях поддержки населения и бизнеса, расходы на приобретение продукции военного назначения уже не являются приоритетными. С другой стороны, вооруженные силы используются для оказания помощи медикам, дезинфекции гражданских объектов и обеспечения безопасности на отдельной территории на круглосуточной основе. Перед высшими органами управления страны встает естественный вопрос: как быть с расходами на национальную оборону в сложившейся ситуации. В статье сделана попытка обобщить международный опыт по данной проблеме.The combination of the pandemic and the economic consequences of quarantine measures introduced to contain it against the backdrop of the oil price war led to the need for a radical review of the state of public finances. On the one hand, now that the government is forced to seek financial resources for multi-million payments to support the population and business, the cost of acquiring military products is no longer a priority. On the other hand, the armed forces are used to assist doctors, disinfect civilian facilities and ensure security in a separate area on a 24-hour basis. The country's highest governing bodies have a natural question: what to do with the costs of national defense in this situation. The article attempts to summarize international experience on this issue.
Talking Head from Speech Audio using a Pre-trained Image Generator
Creators: name: Alghamdi, Mohammed M.
name: Wang, He
name: Bulpitt, Andrew J.
name: Hogg, David C.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: We propose a novel method for generating high-resolution videos of talking-heads from speech audio and a single 'identity' image. Our method is based on a convolutional neural network model that incorporates a pre-trained StyleGAN generator. We model each frame as a point in the latent space of StyleGAN so that a video corresponds to a trajectory through the latent space. Training the network is in two stages. The first stage is to model trajectories in the latent space conditioned on speech utterances. To do this, we use an existing encoder to invert the generator, mapping from each video frame into the latent space. We train a recurrent neural network to map from speech utterances to displacements in the latent space of the image generator. These displacements are relative to the back-projection into the latent space of an identity image chosen from the individuals depicted in the training dataset. In the second stage, we improve the visual quality of the generated videos by tuning the image generator on a single image or a short video of any chosen identity. We evaluate our model on standard measures (PSNR, SSIM, FID and LMD) and show that it significantly outperforms recent state-of-the-art methods on one of two commonly used datasets and gives comparable performance on the other. Finally, we report on ablation experiments that validate the components of the model. The code and videos from experiments can be found at https://mohammedalghamdi.github.io/talking-heads-acm-mm
description: Accepted at ACM Multimedia 2022. The Project webpage can found at https://mohammedalghamdi.github.io/talking-heads-acm-mm