cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Topics in matrix time series analysis
Creators: name: Wu, Fei
Publisher: name: University of Iowa
Year: 2025
Subjects: public abstract

description: This thesis research is motivated by the question of how to effectively detect a specific type of aurora known as pulsating aurora in video data captured by all-sky cameras. By considering each image as a matrix, a video can be represented as a sequence of matrices. These matrix sequences exhibit different patterns during different phases, such as phases with pulsating auroras and phases with no auroras. To capture and analyze this phenomenon, we propose a mixture autoregressive model for matrix-valued time series data. This model enables clustering of the sequences into distinct phases and allows for the study of dynamic patterns within each phase. We propose an EM algorithm for maximum likelihood estimation. We derive some theoretical properties of the proposed method including consistency and asymptotic distribution, and illustrate its performance via simulations and real applications.
description: Furthermore, we propose a parsimonious regression model for modeling matrix-valued data. This model assumes low-rank structures for the parameter matrices. We investigate the asymptotic properties of the least squares estimator and present a regularized approach for simultaneous parameter estimation and rank selection.
description: Given the vast amount of auroral data available, we also implement deep learning techniques, such as image and video classification methods, for aurora detection. Additionally, we introduce a spatiotemporal model for integrating the video data from several cameras across North America.
ПРАВОВОЕ РЕГУЛИРОВАНИЕ ПРИМЕНЕНИЯ СПЕЦИАЛЬНЫХ ПСИХОЛОГИЧЕСКИХ ЗНАНИЙ ПРИ РАССЛЕДОВАНИИ ПРЕСТУПЛЕНИЙ
Creators: name: Ибодуллаева, Нодирабегим
Publisher: name: Zenodo
Year: 2024

description: В работе рассматриваются актуальные вопросы правового регулирования использования специальных психологических знаний в процессе расследования преступлений. Анализируются современные нормативно-правовые основы, регламентирующие применение психологических методов и привлечение специалистов-психологов к следственным действиям. Особое внимание уделяется проблемам процессуального оформления результатов психологических исследований и их доказательственного значения.
Functional analysis of Unp, a mammalian ubiquitin protease.
Creators: name: Blanchette, Paola.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Biology, Molecular.

description: The murine Unp gene encodes a ubiquitously expressed protein that fractionates with the nuclear fraction (hence its name ubiquitous nuclear protein) (Gupta, K., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., and Gray, D. A. (1993). Oncogene 8, 2307-10). It possesses proprieties of an oncogene, such as the ability to promote tumours in a nude mouse assay (Gupta, K., Chevrette, M., and Gray, D. A. (1994). Oncogene 9, 1729--31), and its human homologue, USP4 (previously known as Unph), was shown to be over expressed in certain types of human lung tumours (Gray, D. A., Inazawa, J., Gupta, K., Wong, A., Ueda, R., and Takahashi, T. (1995). Oncogene 10, 2179--83). Although very little was known about this protein's normal function, even less on its mechanism of tumorigenicity, the predicted protein sequence gave some clues on its function. It possesses the two conserved domains present in all ubiquitin specific proteases, and the two motifs common to viral oncoproteins through which they interact with the retinoblastoma gene product pRb. In addition to these features it also possesses a region that resembles a nuclear localisation signal. A mutational approach was taken in combination with ubiquitin cleavage assays and binding assays to study Unp's function. With these, it was confirmed that Unp is a ubiquitin specific protease, its ability to cleave ubiquitin dependent on the conserved cysteine, and may be dependent on Unp phosphorylation status. Unp is a phosphoprotein, being phosphorylated on serine residue(s). It is capable of binding to pRb's hypophosphorylated as well as the hyperphosphorylated forms, a binding that is dependent on an intact conserved motif 2 (CR2). It is also capable of binding to the other pocket proteins, p107 and p130, although with different requirements of conserved regions that for pRb. With these and other results obtained, a model is proposed linking Unp's activity as a deubiquitinating enzyme and its interactions with the pocket proteins with its role as an oncogene. The data obtained also supports the newer view that ubiquitin specific proteases, have a role in the specific regulation of protein levels and not just as general ubiquitin recycling enzymes as previously believed.
title: Crisis facilities as a source of public information
Creators: name: Ergun, Lerby Murat
Publisher: name: Bank of Canada
publisherIdentifier: https://ror.org/05cc98565
publisherIdentifierScheme: ROR
Year: 2025

description: During the COVID-19 financial market crisis, central banks introduced programs to support liquidity in important core funding markets. As well as acting as a backstop to market prices, these programs produce useful trading data on prevailing market conditions. When summary information from this data is shared publicly, it can help market participants understand current conditions and aid the recovery of market functioning.
description: Pendant la crise qui a secoué les marchés financiers lors de la pandémie de COVID-19, les banques centrales ont instauré des programmes visant à maintenir la liquidité des marchés de financement essentiels. En plus de soutenir les prix de marché, ces programmes permettent de recueillir des données sur les opérations, qui éclairent sur les conditions de marché courantes. La publication d’informations sommaires qui sont dégagées de ces données permet aux participants aux marchés de mieux cerner les conditions qui prévalent et contribue à rétablir le bon fonctionnement des marchés.
Study protocol: Comparison of the effect of treatment with Nonsteroidal anti- inflammatory drugs added to anti-tumour necrosis factor a therapy versus anti- tumour necrosis factor a therapy alone on progression of Structural damage in the spine over two years in patients with ankyLosing spondylitis (CONSUL) – an open-label randomized controlled multicenter trial
Creators: name: Proft, Fabian
name: Muche, Burkhard
name: Listing, Joachim
name: Rios-Rodriguez, Valeria
name: Sieper, Joachim
name: Poddubnyy, Denis
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Introduction There is some evidence that non-steroidal anti-inflammatory drugs (NSAIDs), in particular celecoxib, might possess not only a symptomatic efficacy but also disease-modifying properties in ankylosing spondylitis (AS), retarding the progression of structural damage in the spine if taken continuously. In contrast, this remains controversial for tumour necrosis factor alpha (TNF-α) inhibitors, despite their good clinical efficacy. The impact of a combined therapy (a TNF inhibitor plus an NSAID) on radiographic spinal progression in AS is unclear. Methods and analysis The aim of this study is to evaluate the impact of treatment with an NSAID (celecoxib) when added to a TNF inhibitor (golimumab) compared with TNF inhibitor (golimumab) alone on progression of structural damage in the spine over 2 years in patients with AS. The study consists of a 6-week screening period, a 12-week period (phase I: run-in phase) of treatment with golimumab for all subjects followed by a 96-week controlled treatment period (phase II: core phase) with golimumab plus celecoxib versus golimumab alone, and a safety follow-up period of 4 weeks. At week 108, the primary study endpoint radiographic spinal progression (as assessed by the change in the modified Stoke Ankylosing Spondylitis Spine Score after 2 years) will be evaluated. Ethics and dissemination The study will be performed according to the principles of good clinical practice and the German drug law. The written approval of the independent ethics committee and of the German federal authority have been obtained. On study completion, results are expected to be published in a peer- reviewed journal. Trial registration number ClinicalTrials.gov register (NCT02758782) and European Union Clinical Trials Register (EudraCT No 2016-000615-33).
A iron-57 Moessbauer study on the thermal oxidation of iron in biotite mica.
Creators: name: Tume, Pamela.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Physics, Condensed Matter.

description: We have studied the oxidation in air of a well characterized biotite sample. Large single crystal wafers were annealed at various temperatures up to 875$\sp\circ$C and for various times up to 94 hours. The oxidation proceeds primarily via the oxyannite reaction: $\rm (Fe\sp{2+} + OH\sp-)\sb{mica} \to (Fe\sp{3+} + O\sp{2-})\sb{mica} + H$ and was therefore conveniently followed by $\sp{57}$Fe Mossbauer spectroscopy, which resolves the 2+ and 3+ valence states of iron. The main features of the annealing time and temperature dependencies of the $\rm Fe\sp{3+}/Fe\sp{2+}$ amounts are understood in terms of a simple model in which: (i) the overall oxidation reaction proceeds homogeneously via a time-wise bottleneck step that follows a classic thermal activation law and (ii) a certain fraction of the original Fe$\sp{2+}$ is inaccessible to the oxidation reaction. The resulting barrier energy, $\rm E\sb{b} = 2.36\sbsp{-.02}{+.01}$ eV is in the range of measured barrier energies for dehydroxylation of layer silicates. This suggests that the bottleneck step may be local dehydroxylation: $\rm (OH\sp-\ \to O\sp{2-}\ + H\sp+).$ The persistent Fe$\sp{2+}$ can be understood from local crystal-chemical considerations. (Abstract shortened by UMI.)
The structure and function of the heart cell membrane: Characterization of a 360 kDa protein and dystrophin from the myocardium.
Creators: name: Peri, Vita.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Biology, Anatomy.

description: In order to understand the role of the dihydropyridine receptor in excitation-contraction coupling in cardiac cells, a thorough study of the structure and function of this molecule is warranted. During the purification of the dihydropyridine receptor on lectin-affinity columns and sucrose density gradients, a high molecular weight protein (360 kDa) was found to co-purify with the receptor. Since several high molecular weight proteins such as ion channels and dystrophin are associated with the cell membrane, the relationship of the 360 kDa protein to these proteins was investigated. The relationship of the 360 kDa protein with other high molecular weight proteins such as dystrophin was investigated using anti-peptide antibodies against dystrophin. The results suggested that the 360 kDa protein was related to $\alpha\sb2$-macroglobulin. In view of the function of $\alpha\sb2$-macroglobulin as a protease inhibitor, it is speculated that the 360 kDa protein may be performing a similar function in heart cells. The rise in Ca$\sp{2+}$ during systole may lead to activation of Ca$\sp{2+}$-sensitive proteases and the presence of a protease inhibitor in these cells may help prevent the proteolytic degradation of essential proteins such as ion channels and dystrophin. Increased proteolytic degradation in Duchenne muscular dystrophy has been shown to be due to high intracellular Ca$\sp{2+}$ levels as a result of sarcolemmal membrane damage. (Abstract shortened by UMI.)
Two-phase closed thermosyphon with two-fluid mixtures.
Creators: name: Park, Rohjoon.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Engineering, Mechanical.

description: An experimental study was conducted to investigate the performance of stationary two-phase closed thermosyphons with two-fluid mixtures. Three mixtures were used as the working fluids: (1) water-ethanol, (2) water-ethyleneglycol and (3) water-glycerol. The results are presented to show the effects of ratio of two fluid component, mean operating temperature, different fluid mixtures, heat flux and inclination of the thermosyphon with respect to the direction of the gravitational force. An analytical model is presented to predict the variation of the overall heat transfer coefficients with mole fraction for the thermosyphon with binary mixtures. A good agreement between the prediction by the model and the experimental results was obtained.
XTEN as Biological Alternative to PEGylation Allows Complete Expression of a Protease-Activatable Killin-Based Cytostatic
Creators: name: Haeckel, Akvile
name: Appler, Franziska
name: De Schellenberger, Angela Ariza
name: Schellenberger, Eyk
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Increased effectiveness and reduced side effects are general goals in drug research, especially important in cancer therapy. The aim of this study was to design a long-circulating, activatable cytostatic drug that is completely producible in E. coli. Crucial for this goal was the novel unstructured polypeptide XTEN, which acts like polyethylene glycol (PEG) but has many important advantages. Most importantly, it can be produced in E. coli, is less immunogenic, and is biodegradable. We tested constructs containing a fragment of Killin as cytostatic/cytotoxic element, a cell-penetrating peptide, an MMP-2 cleavage site for specific activation, and XTEN for long blood circulation and deactivation of Killin. One of three sequence variants was efficiently expressed in E. coli. As typical for XTEN, it allowed efficient purification of the E. coli lysate by a heat step (10 min 75°C) and subsequent anion exchange chromatography using XTEN as purification tag. After 24 h XTEN- Killin reduced the number of viable cells of HT-1080 tumor cell line to 3.8 ±2.0% (p<0.001) compared to untreated controls. In contrast, liver derived non-tumor cells (BRL3A) did not show significant changes in viability. Our results demonstrate the feasibility of completely producing a complex protease-activatable, potentially long-circulating cytostatic/cytotoxic prodrug in E. coli—a concept that could lead to efficient production of highly multifunctional drugs in the future.
Information World Mapping : A Participatory Arts-Based Elicitation Method for Information Behavior Interviews
Creators: name: Greyson, Devon
name: O'Brien, Heather, 1977-
name: Shoveller, Jean
Publisher: name: The University of British Columbia
Year: 2018

description: Participatory, arts-based methods generate rich data with which researchers can explore information behavior in context, and may be particularly apt when engaging with youth or participants with low literacy levels. Information world mapping (IWM) is an innovative and interactive drawing-based interview technique for data elicitation. Initially developed for use in a study of young parents’ health information practices, IWM guides participants in depicting their personal social information worlds, including items, places, and relationships. Maps are then used to facilitate critical incident elicitation from participants' stories about, and interpretations of, their information practices. Within the young parent study, three styles of map were commonly seen: the directional map, the mind map, and the symbolic map. Use of IWM requires time and ethical care, but the method enables researchers to center participants’ own perspectives on information practices, triangulate data obtained via more traditional methods, and enrich understanding of social information worlds.
Evaluating the risk of milling-induced polymorphism
Creators: name: Young, Beth Ann
Publisher: name: University of Iowa
Year: 2022
Subjects: Amorphization
Critical Dislocation Model
Polymorphism
Powder Brillouin Light Scattering
Slip
public abstract
Mechanical Properties

description: Many pharmaceutical materials exhibit polymorphism, a phenomenon in which a material exists in more than one crystal form. Polymorphic forms can differ in many physicochemical
description: properties, resulting in changes to drug efficacy, processibility, and bioavailability.
description: Polymorphism can occur through various conditions, e.g., milling. Milling is the process of
description: grinding or crushing coarse particle to produce finer particulates for manufacturing. To evaluate
description: the risk of milling-induced polymorphism we have investigated the transitions, mechanism, and
description: stability of two model systems: sulfamerazine and indomethacin. We have found that both
description: systems proceed through an amorphous intermediate, a noncrystalline solid, while the mill
description: provided increased temperatures driving the recrystallizations of both systems to a “metastable”
description: form. Understanding these parameters will help provide insight into protecting against unwanted
description: polymorphic conversions via milling.
DEP Bulletin - 2022 - Volume 46 Issue 13
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 2022

description: The DEP bulletin is a semi-monthly publication of the New Jersey Department of Environmental Protection. It contains a list of construction permit applications recently filed or acted upon by the Department along with a calendar of events of interest, a schedule of public hearings, and Environmental Impact Statements acted upon during the period.
Electrochemical analysis of redox-active systems for energy storage and conversion applications
Creators: name: Stumme, Nathan Christopher
Publisher: name: University of Iowa
Year: 2023
Subjects: Electrocatalysis
Energy Conversion
Energy Storage
Metal-ligand cooperativity
Redox-flow batteries
public abstract
Electrochemistry

description: The work in this dissertation overviews the fundamental electrochemical, physical, and spectroscopic analysis of redox-active systems for CO2 electrocatalysis and energy storage. With global impacts from climate change, decreases in carbon emissions have come through producing and storing energy with carbon-free renewable sources, as well as the conversion of carbon sources such as CO2 into value-added products. My research spans both of these approaches, from the study of organic redox-active molecules for intermittent energy storage to the systematic electrochemical characterization of electrocatalysts designed for CO2 reduction. While my research projects are distinct, they are linked through the common theme of using electrochemistry and the information it provides to improve energy technologies. My energy storage research focuses on the systematic characterization of a series of non-aqueous organic redox-active molecules for use in redox flow batteries. Various concentrations of redox-active species and electrolyte are electrochemically characterized to elucidate the implication of concentration on battery performance parameters. Spectroscopic analysis also reveals information on the solvation environments of these species at varying concentrations and charge states and the impact of intermolecular interactions on electron transfers.
description: My work in CO2 electrocatalysis explores coordination complexes with metal-ligand cooperativity (MLC) and redox-active ligands, both of which can be tuned to impact substrate binding strength and catalytic activity. Fundamental electrochemical characterization of a series of these coordination complexes is coupled with equilibrium modeling to quantify binding strength and ultimately connect it to electrochemical properties and ligand design. Insights from this work inform the design of coordination complexes that are then tested for preliminary electrochemical CO2 reduction performance.
title: Ressourcenschonende Bauwerke - EPD für Bauprodukte: Rückbau- und Recycling-informationen (Modul C und D) sowie Schadstoffangaben
title: Ressourcenschonende Bauwerke - EPD für Bauprodukte
titleType: AlternativeTitle
Creators: name: Trinius, Wolfram
name: Sievert, Julia
name: Schmincke, Eva
Publisher: name: Umweltbundesamt
Year: 2020
Subjects: subject: Ressourcenschonung
subject: Umweltgerechtes Bauen
subject: Recycling
subject: Kreislaufwirtschaft
subject: Bauschutt
subject: EPD
subject: Nachhaltiges Bauen
subject: Bauprodukte
subject: Abbruchmaterial
subject: Abfall | Ressourcen

description: Der Sachstandsbericht wird projektbegleitend fortgeschrieben. Die hier vorliegende Fassung ist der abschließende Projektbericht. Darin werden Kernpunkte der Entwicklung des Projekts festgehalten. Quelle: Forschungsbericht
description: Der vorgelegte Bericht dokumentiert den Verlauf des REFOPLAN-Projekts „Ressourcenschonende Bauwerke – EPD für Bauprodukte: Rückbau- und Recyclinginformationen (Modul C und D) sowie Schadstoffangaben“. Ziel des Projekts war es, einen Leitfaden für die europäische Bauproduktnormung zu erstellen. Er soll die Gremien für die Normung von Bauprodukten (Product TCs, Technical Committees) dabei unterstützen, Vorgaben für Umweltproduktdeklarationen (EPD) nach EN 15804 zu entwickeln, die auch das Ende des Lebenszyklus der Produkte (Module C und D gemäß o.g. Norm) betrachten.
title: Centering black therapists in practice
title: exploring factors contributing to retention and attrition
titleType: Subtitle
Creators: name: Hamilton, Alexus M
Publisher: name: University of Iowa
Year: 2023
Subjects: Black
Couple and Family Therapy
Racism
Therapist
Therapy Training
public abstract
Discrimination

description: This dissertation employs a systematic review synthesis and a framework analysis to explore factors contributing to Black therapists' attrition and retention in the mental health field. These studies utilized an integration of Social Stress Theory and Critical Race Theory to find racism may be a major contributor to burnout, and burnout may be a major contributor to attrition. Additionally, findings suggest Black therapists shifting to seeing more Black clients helps bolster Black therapist's retention in the field. These studies were conducted to not only increase Black representation in therapy but also to retain the Black therapists that are already in the field. Implications for training are discussed.
title: The Rastafari and the nation of Islam
title: from Black internationalism to globalization, 1960s–1980s
titleType: Subtitle
Creators: name: Mills, Troy R.
Publisher: name: University of Iowa
Year: 2022
Subjects: Black Internationalism
Black Nationalism
Nation of Islam
Pan-Africanism
Rastafari
public abstract
Globalization
African American Studies

description: This dissertation is a comparative historical study that explores how the Rastafari in Jamaica and the Nation of Islam (NOI) in the United States (US) reoriented black religious consciousness and identity as well as the political strategies of Black Internationalism to engage in a more self-determined globalization of so-called “blackness” during the periods of decolonization, the Civil Rights, and the Black Power Movements. The Rastafari and the NOI did so by using existing global communication structures, long dominated by the master narrative of Eurocentrism, to transmit the spiritual and theological messages of their respective religious communities, which reinvigorated the struggles for black liberation and human rights in the 1960s to the 1980s. The main research questions are: should black identity be defined solely or collectively by national boundaries, ethnic/cultural and linguistic differences, or religious affiliations? How different were the NOI’s and the Rastafari’s strategies to form corporate black identity? What experiences form black identity in the US and Caribbean? How do we make sense of what it means to be black in the US as opposed to in the Caribbean? The central arguments are: I argue that iconic young black religious and spiritual leaders like Bob Marley and Malcolm X embodied the re-imagination of this vibrant new psychological alterations that ushered in the promise and warrant of new leadership in the mid- to late twentieth century. I argue that the shift from Black Internationalism toward globalization stemmed from a growing awareness among African-descended peoples that while forging unity among Africans and other oppressed peoples insulated them from structural and institutional racism, their goal of universal freedom and racial equity would not be achieved unless they leveraged this sometimes real and often imaginary unity to challenge European power structures globally.
Reshaping the e-health landscape: how interdisciplinary research drives innovation in broadband applications
Creators: name: Tucker, Rod
name: Lodders, Adam
Publisher: name: Swinburne
Year: 2024

description: High-speed broadband provides a platform for a wide range of applications, including ehealth. The development of e-health applications has to take into account diverse bodies of knowledge, from the appropriate configuration of network technologies through to the clinical deployment of new treatments. Thus, interdisciplinary research is central to e-health. The Institute for a Broadband-Enabled Society (IBES) was established at the University of Melbourne to support interdisciplinary research that leverages the benefits of ubiquitous highspeed broadband networks, such as the emerging National Broadband Network. Research into health and wellbeing is central to the Institute. This paper discusses how interdisciplinary research drives the development of e-health solutions focusing specifically on three case studies - stroke rehabilitation, mental health, and education and training.
Metaphor, the press, and the Canadian Security Intelligence Service (CSIS).
Creators: name: Tracey, Neil R.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Sociology, Criminology and Penology.

description: The dissemination of press information in areas of concern to criminal justice plays an important role in the public conceptions of crime and the criminal justice system. The theoretical basis of the work, which integrates studies in phenomenology and metaphor, serves as a vehicle to arrive at a critical understanding of the press portrayal of the security legislation (CSIS Act). The thesis studies press articles gathered from microfilms, government press clippings, and a computer search (Dialog, File 262) for the Vancouver Sun, Winnipeg Free Press, Toronto Globe and Mail, Toronto Star, Ottawa Citizen, Ottawa Le Droit, Montreal Gazette, Le Devoir. Specific sub-themes in the reporting of the CSIS indicate that: (1) the reporting was uniformly critical of the bill, (2) the issue of civil rights versus state security provided the boundaries of virtually all coverage, (3) the CSIS was consistently portrayed through totalitarian imagery. (Abstract shortened by UMI.)
Protocol engineering issues for open systems communications.
Creators: name: Aleem, Syed A.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Computer Science.

description: In this thesis we present real design criteria and design building blocks in a highly procedural way starting from the specification to the implementation stage. A subset of a real protocol, namely ISDN Q.931 (CCIT3), written in informal English will be translated to a formal specification using Estelle as the formal description technique. A means of incorporating the design criteria into the formal description of the protocol is presented and illustrated with Q.931 as example. This thesis will also derive the services a protocol expects from the operating system. Those services will be summarized and standardized in order to limit variability in the design process of a protocol. The system interface which has been a major source of variation in protocol implementation, will reduce to a set of a few well defined standard system calls by assuming a proposed standard operating system interface. This interface standard appears to be sufficient to allow the automatic development of complete protocol software. (Abstract shortened by UMI.)
The voices of those who served: The early war years and the men of the 1st Battalion, Cameron Highlanders of Ottawa (MG).
Creators: name: Morrison, Gloria Alice.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: History, Canadian.

description: The intent of this endeavor is to consider the Second World War from the perspective of one group of men who served with a machine gun regiment based out of Ottawa. The objective is to rediscover what the early war experience was like for these Canadian soldiers. All the questions considered in this undertaking may be subsumed into three basic queries: Who were these men who came forward to serve? Why had they 'volunteered' to go to war? And, what were the early war years like for these predominantly young Canadians? The third query comprises the bulk of the attention in this thesis. The time period under review is from September 1939 until May of 1941. This covers the mobilization period in Ottawa and the unit's first overseas posting in Iceland. This time frame concerns an overlooked aspect of war service---the induction and foundation period for Canadian Armed Forces. (Abstract shortened by UMI.)
Individual neurons in the rat lateral habenular complex project mostly to the dopaminergic ventral tegmental area or to the serotonergic raphe nuclei.
Creators: name: Bernard, René
name: Veh, Rüdiger
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2012
Subjects: subject: dopamine
subject: serotonin
subject: fluorogold
subject: retrograge
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::572 Biochemie
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie

description: The lateral habenular complex (LHb) is a bilateral epithalamic brain structure involved in the modulation of ascending monoamine systems in response to afferents from limbic regions and basal ganglia. The LHb is implicated in various biological functions, such as reward, sleep-wake cycle, feeding, pain processing, and memory formation. The modulatory role of the LHb is partially assumed by putative spontaneously active LHb neurons projecting to the dopaminergic ventral tegmental area (VTA) and to the serotonergic median (MnR) and dorsal raphe nuclei (DR). All four nuclei form a complex and coordinated network to evoke appropriate responses to reward-related stimuli. At present it is not known whether individual LHb neurons project to only one or to more than one monoaminergic nucleus. To answer this question, we made dual injections of two different retrograde tracers into the rat VTA and either DR or MnR. Tracers were visualized by immunohistochemistry. In coronal sections, the different retrogradly labeled habenular neurons were quantified and assigned to the corresponding habenular subnuclei. Our results show that 1) the distribution of neurons in the LHb projecting to the three monoamine nuclei is similar and exhibits a great overlap, 2) the vast majority of LHb projection neurons target one monoaminergic nucleus only, and 3) very few, heterogeneously distributed LHb neurons project to both dopaminergic and serotonergic nuclei. These results imply that the LHb forms both separate and interconnected circuits with each monoaminergic nucleus, permitting the LHb to modulate its output to different monoamine systems either independently or jointly.
Reliability prediction techniques.
Creators: name: De Mercado, John B.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1969
Subjects: subject: Engineering, Electronics and Electrical.

description: This thesis considers methods for predicting reliability and mean time to first failure of complex systems. The need for these methods, is a result of recent advances in pure materials technology and fabrication procedures, that potentially lead to more reliable systems. In this thesis, two types of complex systems are considered. Chapter I, treats systems, with k independent parameters, each exhibiting degradation failure. A model is developed for predicting, the reliability and mean life of such systems, from data taken early in life tests. Therefore saving many hours of test time; and eliminating the need of testing to failure. Chapter II, treats complex systems composed of independent systems, each exhibiting constant failure and repair rates. From the verbal description of a complex system, a Markov model is developed, from which predictions of reliability, availability and mean time to first failure, are made. This model also allows for the inclusion of a random waiting time between failure and beginning of repair.
title: Sacrificing basic needs to achieve the “American Dream”
title: examining the role of postsecondary students’ citizenship status in experiencing basic needs insecurity
titleType: Subtitle
Creators: name: Jangjou, Elmira
Publisher: name: University of Iowa
Year: 2025
Subjects: Basic Needs Insecurity
Citizenship and Residency Status
public abstract
Higher Education

description: This three-article dissertation explores the issue of basic needs insecurity among postsecondary students, with a particular focus on students who are not U.S. citizens or permanent residents (NCPR). Despite the increasing awareness of basic needs insecurity and its adverse impacts on students' academic achievement and well-being, the racial and social inequities in these experiences remain a critical issue requiring scholarly attention. The objective of the first article is to gain a better understanding of the immediate impacts of the COVID-19 pandemic on the student clients of a campus food pantry, regardless of their citizenship/residency status. This qualitative study also provides insight into these students’ initial coping strategies to endure the effects of the pandemic and the importance of campus food pantries in addressing basic needs insecurity. Using the #RealCollege Survey Dataset, the second study investigates the prevalence of basic needs insecurity among postsecondary students according to their citizenship/residency status and reveals that NCPR students are disproportionately affected by basic needs insecurity. It also explores several barriers to NCPR students’ basic needs security, including the reasons why some students do not use campus resources (e.g., not knowing how to apply). The last study examines multiple help-seeking behaviors among NCPR students (e.g., receiving assistance from public and university-affiliated resources) to cope with the issue of basic needs insecurity. The findings of this dissertation suggest that addressing the barriers to students' basic needs security and their help-seeking behaviors requires considering multiple intersecting identities, including citizenship/residency status. I also discuss how higher education institutions can and should appropriately address the related issues and provide adequate support based on students’ unique circumstances.
Constructing Knowledge and Ignorance in the Social Information Worlds of Young Mothers
Creators: name: Greyson, Devon
name: O'Brien, Heather, 1977-
name: Shoveller, Jean
Publisher: name: The University of British Columbia
Year: 2018

description: The socially-constructed information worlds within which individuals live, work, and play necessarily shape their information practices. One way in which this occurs is through the social construction of knowledge, expertise, and ignorance, including which actors are considered to possess authoritative knowledge through administrative authority or “lay” expertise. Using Adele Clarke’s situational mapping techniques, this paper examines the discursive construction of knowledge and ignorance in the information worlds of young mothers in the Greater Vancouver region of Canada. Data was collected via observations at school-based Young Parent Programs and interviews with 37 young mothers over a 15-month time period. Gendered and racialized young parent social worlds discursively constructed the “teen mom” as knowledgeable in matters of sexuality and technology, and ignorant in matters of parenting and health. Further, certain forms of experiential expertise common to marginalized groups were sometimes constructed in such information worlds as forms of ignorance. Recognizing the diversity of knowledge and expertise among young mothers rather than perceiving them as unilaterally information poor may lead to improved information and support services for young parents.
Amelioration of intestinal and systemic sequelae of murine Campylobacter jejuni infection by probiotic VSL#3 treatment
Creators: name: Ekmekciu, Ira
name: Fiebiger, Ulrike
name: Stingl, Kerstin
name: Bereswill, Stefan
name: Heimesaat, Markus M.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Probiotic compound
subject: VSL#3
subject: Secondary abiotic mice
subject: Gnotobiotic mice
subject: Bacterial in vivo competition
subject: Pathogen–commensal bacteria–host interaction
subject: Apoptosis
subject: Innate and adaptive immune cells
subject: Pro-inflammatory cytokines
subject: Anti-inflammatory cytokines
subject: Extra-intestinal and systemic sequelae of infection
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background The incidence of human Campylobacter jejuni infections is progressively increasing worldwide. Probiotic compounds might open up valuable tools to decrease pathogen burden and subsequent pro-inflammatory immune responses, but in vivo data are scarce. Methods and results Secondary abiotic mice generated by broad-spectrum antibiotic treatment were perorally challenged with the commercial probiotic compound VSL#3 consisting of Streptococcus thermophilus, Bifidobacterium breve, Bifidobacterium longum, Bifidobacterium infantis, Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus paracasei, and Lactobacillus delbrueckii ssp. bulgaricus) either 5 days before (i.e. prophylactic regimen) or after (i.e. therapeutic regimen) peroral C. jejuni strain 81–176 infection, and analyzed 3 weeks following the initial bacterial re-association. Upon challenge, mice were colonized with the probiotic bacteria and/or C. jejuni at comparable intestinal loads, but co- colonization did not result in reduction of the pathogen burden. Remarkably, prophylactic as well as therapeutic VSL#3 treatment of C. jejuni infected mice ameliorated intestinal apoptosis and pro-inflammatory immune responses as indicated by lower numbers of innate and adaptive immune cell populations in the murine colon upon probiotic prophylaxis or treatment and reduced colonic concentrations of pro-inflammatory mediators including IL-6 and MCP-1. Importantly, concentrations of anti-inflammatory mediators such as IL-10 were significantly elevated in the colon of probiotics treated mice as compared to untreated controls. Strikingly, prophylactic VSL#3 treatment attenuated C. jejuni induced systemic pro-inflammatory responses as indicated by less TNF and IL-12p70 secretion in the spleen of VSL#3 pre-treated as compared to non- treated mice. Conclusion Administration of probiotic formulations such as VSL#3 might open up valuable strategies for prophylaxis and/or treatment of C. jejuni induced intestinal and systemic sequelae in vivo by the suppression of pro-inflammatory and induction of anti-inflammatory responses.
title: The Trial
title: a stage adaptation by Peter Weiss, in translation
titleType: Subtitle
Creators: name: Ferguson, Nathan
Publisher: name: University of Iowa
Year: 2023
Subjects: Adaptation
German
Peter Weiss
Theatre
Translation studies
public abstract
Translation

description: In 1974, while still working on his masterpiece The Aesthetics of Resistance, Peter Weiss was invited by Ingmar Bergman to write a stage adaptation of Kafka's novel, The Trial. Bergman expected a "bold experiment," but Weiss, an admirer of Kafka's work since childhood, stuck doggedly to the book, though he could not resist including his own politically charged reading. The result was a meticulous adaptation, with great care taken to preserve many of the key ideas and passages from the novel, but with noticeable additions, compiled from unfinished scenes and other Kafka materials, changed to make the ideological point. Until now, this play has not been available in English; my translation is (as far as I am aware) the first. Included is a commentary on the structure and dynamics of the work, and how I chose to translate the more difficult parts of that structure.
Model selection posterior predictive model checking via limited-information indices for Bayesian diagnostic classification modeling
Creators: name: Zhang, Jihong
Publisher: name: University of Iowa
Year: 2022
Subjects: Bayesian Network
Cognitive diagnosis
Diagnostic Classification Model
model fit
public abstract

description: Recently, Bayesian diagnostic classification modeling has been becoming popular in health psychology, education, and sociology. Typically information criteria are used for model selection when researchers want to choose the best model among alternative models. In Bayesian estimation, posterior predictive checking is a flexible Bayesian model evaluation tool, which allows researchers to detect Q-matrix misspecification. However, model selection methods using posterior predictive checking (PPC) for Bayesian DCM are not well investigated. Thus, this research aims to propose a novel model selection approach using posterior predictive checking with limited–information statistics for selecting the correct Q–matrix. A simulation study was conducted to examine the performance of the proposed method. Furthermore, an empirical example was provided to illustrate how it can be used in real scenarios.
Insulin Degrading Enzyme And Its Role In Atherosclerosis
Creators: name: Caravaggio, Justin W
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Biology, Molecular.

description: The type-A scavenger receptor (SR-A) plays a major role in the uptake of modified lipoproteins leading to foam cell formation and fatty streak development in artery walls. Our lab previously showed that a peptide known as insulin degrading enzyme (IDE) is able to bind the SR-A cytoplasmic domain in vitro. The present study provides evidence that male low density lipoprotein receptor-null (LDLr-/-) mice on a high fat diet, generate significantly more atherosclerotic lesion in aortic root and the aortic intimal surface when reconstituted with IDE-null (IDE-/-) bone marrow derived cells compared to those reconstituted with wild type bone marrow. Total serum cholesterol and the LDLr cholesterol fraction was also significantly increased in male LDLr-/- mice reconstituted with IDE-/- bone marrow. Macrophages procured from IDE-/- mice showed no difference in uptake of modified LDL compared to wild type cells but may be able to accumulate more cholestertyl ester than wild type cells. Our findings reveal that IDE expression likely exerts an anti-atherogenic effect via cholesterol metabolism, although further in vitro experiments are required to elucidate an exact mechanism.
Effects of Renal Denervation on Renal Artery Function in Humans: Preliminary Study
Creators: name: Doltra, Adelina
name: Hartmann, Arthur
name: Stawowy, Philipp
name: Goubergrits, Leonid
name: Kuehne, Titus
name: Wellnhofer, Ernst
name: Gebker, Rolf
name: Schneeweis, Christopher
name: Schnackenburg, Bernhard
name: Esler, Murray
name: Fleck, Eckart
name: Kelle, Sebastian
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Aim To study the effects of RD on renal artery wall function non-invasively using magnetic resonance. Methods and Results 32 patients undergoing RD were included. A 3.0 Tesla magnetic resonance of the renal arteries was performed before RD and after 6-month. We quantified the vessel sharpness of both renal arteries using a quantitative analysis tool (Soap-Bubble®). In 17 patients we assessed the maximal and minimal cross-sectional area of both arteries, peak velocity, mean flow, and renal artery distensibility. In a subset of patients wall shear stress was assessed with computational flow dynamics. Neither renal artery sharpness nor renal artery distensibility differed significantly. A significant increase in minimal and maximal areas (by 25.3%, p = 0.008, and 24.6%, p = 0.007, respectively), peak velocity (by 16.9%, p = 0.021), and mean flow (by 22.4%, p = 0.007) was observed after RD. Wall shear stress significantly decreased (by 25%, p = 0.029). These effects were observed in blood pressure responders and non-responders. Conclusions RD is not associated with adverse effects at renal artery level, and leads to an increase in cross- sectional areas, velocity and flow and a decrease in wall shear stress.
An investigation of accessibility and availability of audiologists in Iowa
Creators: name: Chau, Alexander Hoc
Publisher: name: University of Iowa
Year: 2023

description: No previous research has been conducted examining the accessibility and availability of audiology businesses for adults in Iowa. The aim of this study was to examine the accessibility and availability of audiology businesses and clinics in Iowa by examining the geographic distribution of audiology businesses at the county-level (availability) and calculating estimated travel distances and times (by car) from estimated locations of older adults (≥ 65 years) with hearing loss to the nearest audiology business and creating distance buffer zones around each audiology business (accessibility) using geographic information systems (GIS) software and methodology. Estimated population data obtained from the U.S. Census Bureau’s American Community Survey (ACS) and Decennial Census datasets, in conjunction with using estimated hearing loss rates to calculate the amount of individuals ≥ 65 years with hearing loss in each county. Counties in Iowa were stratified by metropolitan (i.e., urban) or nonmetropolitan (i.e., mix of urban and/or rural) classifications. The findings show that older adults with hearing loss living in nonmetropolitan counties experience longer mean drive distances and times to the nearest audiology business than in metropolitan counties (16.1 vs 10.7 miles, respectively), audiology businesses tended to locate more in nonmetropolitan counties than metropolitan counties, and there was not a statistically significant difference for proportions of older adults with hearing loss between counties that contained zero audiology businesses compared to counties that had at least one audiology business. These results are partly supported by previous studies at different geographic areas at similar scales, and suggest that there are accessibility and availability disparities for older adults with hearing loss living in nonmetropolitan counties compared to those in metropolitan counties that need to be addressed by public policy makers.
Nódulos tireoidianos: quando puncionar?
Creators: name: Ranniery Caetano Sampaio Martins Frade
Publisher: name: Zenodo
Year: 2024

description: Nódulos tireoidianos são achados comuns na prática clínica, e a decisão de puncioná-los depende de múltiplos fatores. Este artigo revisa os critérios para indicação de punção aspirativa por agulha fina (PAAF), abordando aspectos como tamanho, características ultrassonográficas, histórico clínico e fatores de risco associados ao câncer de tireoide. Também são discutidos os benefícios e limitações da PAAF, além da importância de uma avaliação criteriosa para evitar tanto procedimentos desnecessários quanto atrasos no diagnóstico de malignidades. Conclui-se que a PAAF é uma ferramenta valiosa na avaliação dos nódulos tireoidianos, desde que utilizada de forma criteriosa e baseada em evidências.