cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
VLT X-shooter spectroscopy of the nearest brown dwarf binary
Creators: name: Lodieu, N.
name: Osorio, M. R. Zapatero
name: Rebolo, R.
name: Bejar, V. J. S.
name: Pavlenko, Y.
name: Perez-Garrido, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The aim of the project is to characterise both components of the nearest brown dwarf sytem to the Sun, WISE J104915.57-531906.1 (=Luhman16AB) at optical and near-infrared wavelengths. We obtained high signal-to-noise intermediate-resolution (R~6000-11000) optical (600-1000 nm) and near-infrared (1000-2480nm) spectra of each component of Luhman16AB, the closest brown dwarf binary to the Sun, with the X-Shooter instrument on the Very Large Telescope. We classify the primary and secondary of the Luhman16 system as L6-L7.5 and T0+/-1, respectively, in agreement with previous measurements published in the literature. We present measurements of the lithium pseudo-equivalent widths, which appears of similar strength on both components (8.2+/-1.0 Angstroms and 8.4+/-1.5 Angstroms for the L and T components, respectively). The presence of lithium (Lithium 7) in both components imply masses below 0.06 Msun while comparison with models suggests lower limits of 0.04 Msun. The detection of lithium in the T component is the first of its kind. Similarly, we assess the strength of other alkali lines (e.g. pseudo-equivalent widths of 6-7 Angstroms for RbI and 4-7 Angstroms for CsI) present in the optical and near-infrared regions and compare with estimates for L and T dwarfs. We also derive effective temperatures and luminosities of each component of the binary: -4.66+/-0.08 dex and 1305(+180)(-135) for the L dwarf and -4.68+/-0.13 dex and 1320(+185)(-135) for the T dwarf, respectively. Using our radial velocity determinations, the binary does not appear to belong to any of the well-known moving group. Our preliminary theoretical analysis of the optical and J-band spectra indicates that the L- and T-type spectra can be reproduced with a single temperature and gravity but different relative chemical abundances which impact strongly the spectral energy distribution of L/T transition objects.
description: 12 pages, 9 figure, 3 tables, accepted to A&A
Il cosmo come mezzo, il cosmo come fine: il Timeo di Platone, Empedocle e Aristotele sulla relazione tra macrocosmo e microcosmo
Creators: name: Casella, Federico
Publisher: name: Thaumàzein | Rivista di Filosofia
Year: 2022

description: The aim of this paper is to analyze the ethical relevance of the analysis of the cosmos offered by Plato in his Timaeus. In this dialogue, the study of the sensible cosmos reveals both that it depends on its noetic model and that it is a rational, ordered, perfect, and self-sufficient living being. Plato also shows how humans are closely related to the cosmos: they share the same origin and possess a similar conformation. It follows that, in order to be considered perfect, humans must imitate the characteristics of the sensible cosmos and then devote their lives to the noblest activity, the study of ideas, i.e. the intelligible cosmos. If humans abide by this way of life, their souls will reside eternally among the stars – rational divinities – after their separation from the body, and thus enjoy perpetual happiness. This paper will also consider Presocratic thought and especially Empedocles’ claim that the study of the characteristics of the cosmos and their imitation play a pivotal role in identifying the fairest human conduct. Finally, this paper will briefly examine Aristotle’s theory of teleological nature and cosmological order, so as to show any convergence or contrast between Empedocles, Plato, and Aristotle on the relationship between macrocosm and human microcosm in Archaic and Classical Greek Philosophy.
description: Thaumàzein | Rivista di Filosofia, Vol. 10 No. 2 (2022): Cosmologia filosofica / Philosophical Cosmology
Treating Central Catheter–Associated Bacteremia Due to Methicillin-Resistant Staphylococcus aureus: Beyond Vancomycin
Creators: name: Holt, Shannon
name: Lipetzky, Juliana
name: Ryan Sparks,
name: Thompson-Brazill, Kelly A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Methicillin-resistant Staphylococcus aureus is a frequent cause of hospital-associated infections, including central catheter-associated bacteremia. Vancomycin has been the drug of choice for treating this type of bacteremia for decades in patients who have no contraindications to the antibiotic. However, resistance to vancomycin is an emerging problem. Newer antibiotics approved by the Food and Drug Administration have activity against methicillin-resistant S aureus Some of the antibiotics also have activity against strains of S aureus that are intermediately susceptible or resistant to vancomycin. This article uses a case study to highlight the clinical signs of vancomycin failure and describes the indications for and appropriate use of alternative antimicrobials such as ceftaroline, daptomycin, linezolid, tigecycline, and telavancin. (Critical Care Nurse 2016;36[4]:46-57).
title: Quantification of myocardial extra-cellular volume (ECV) in adenosine stress/rest perfusion CMR examinations: effect of contrast dose
Creators: name: Caballeros, Fanny
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Cardiac
subject: MR-Diffusion/Perfusion
subject: Diagnostic procedure
subject: Contrast agent-intravenous
subject: Ischaemia / Infarction

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: CMR examinations performed under adenosine-induced stress are increasingly being used in daily clinical routine (1). (Fig. 3) Traditional late gadolinium enhancement (LGE) images enable to differentiate ischemic from non-ischemic cardiomyopathies by...
Organoids: A New Chapter in Sarcoma Diagnosis and Treatment
Creators: name: Psilopatis, Iason
name: Kokkali, Stefania
name: Palamaris, Kostas
name: Digklia, Antonia
name: Vrettou, Kleio
name: Theocharis, Stamatios
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: organoids
subject: sarcoma
subject: three-dimensional cell culture
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Sarcomas are malignant tumors of mesenchymal origin that can occur at any age. The rarity of these tumors in combination with the vast number of histological subtypes render the study of sarcomas challenging. Organoids represent complex three-dimensional cell culture systems, deriving from stem cells and preserving the capacity to differentiate into the cell types of their tissue of origin. The aim of the present review is to study the current status of patient-derived organoids, as well as their potential to model tumorigenesis and perform drug screenings for sarcomas. In order to identify relevant studies, a literature review was conducted and we were able to identify 16 studies published between 2019 and 2022. The current manuscript represents the first comprehensive review of the literature focusing on the use of organoids for disease modelling and drug sensitivity testing in diverse sarcoma subtypes.
Coupled-Channel Model for $\bar{K}N$ Scattering in the Resonant Region
Creators: name: Fernandez-Ramirez, C.
name: Danilkin, I. V.
name: Manley, D. M.
name: Mathieu, V.
name: Szczepaniak, A. P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We present a unitary multichannel model for $\bar{K}N$ scattering in the resonance region that fulfills unitarity. It has the correct analytical properties for the amplitudes once they are extended to the complex-$s$ plane and the partial waves have the right threshold behavior. To determine the parameters of the model, we have fitted single-energy partial waves up to $J=7/2$ and up to 2.15 GeV of energy in the center-of-mass reference frame obtaining the poles of the $Λ^*$ and $Σ^*$ resonances, which are compared to previous analyses. We provide the most comprehensive picture of the $S=-1$ hyperon spectrum to date. Important differences are found between the available analyses making the gathering of further experimental information on $\bar{K}N$ scattering mandatory to make progress in the assessment of the hyperon spectrum.
description: Joint Physics Analysis Center, 28 pages, 19 figures, 3 tables
title: Pretreatment tumour CT density is associated with overall and progression-free survival and tumour growth in patients with metastatic renal cell carcinoma under antiangiogenic therapy
Creators: name: Matoori, Simon
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Oncology
subject: Kidney
subject: CT
subject: CT-Quantitative
subject: Contrast agent-intravenous
subject: Chemotherapy
subject: Metastases

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Kidney cancer is currently the ninth and fourteenth most common cancer in men and women, respectively, and accounts for 143 000 deaths worldwide in the year 2012[1]. Renal cell carcinoma (RCC) is responsible for 90% of kidney cancer cases[2]....
title: Wearables und individuelle digitale Souveränität
Creators: name: Schauermann, Elisabeth
name: Gruber, Clemens
name: Croll, Jutta
name: Arend, Matthias
name: Pütz, Sebastian
name: Nitzsch, Verena
name: Stellmacher, Carolin
name: Buschhaus, Constantin
name: Butting, Arvid
name: Hillemacher, Steffen
name: Michael, Judith
name: Rumpe, Bernhard
name: Conradie, Niel
name: Nagel, Saskia
name: Gundelach, Ralf
name: Herrmann, Dominik
name: Fehler, Manuel
name: Angenvoort, Johannes
Publisher: name: Gesellschaft für Informatik e.V.
Year: 2023

description: Tragbare Gesundheitstechnologien, so genannte Wearables, finden immer mehr Verbreitung. Sowohl bei Freizeitsportler*innen, die ihre Fitness und Lebensführung darüber nachvollziehen und quantifizieren möchten, als auch in der medizinischen Versorgung und Prävention, in der Altenpflege und in Industriebetrieben kommen sie zum Einsatz. Mit einer Vielzahl an Sensoren erfassen diese Geräte sensible Gesundheitsdaten direkt am Körper sowie Standort- und Bewegungsdaten. Aus der Analyse und Verknüpfung dieser Informationen können je nach Einsatzbereich wertvolle Erkenntnisse gezogen werden. Jedoch ist es durch die Art der verarbeiteten, mitunter sehr intimen Daten und durch die Implikationen für die Privatsphäre besonders wichtig, dass Nutzenden Informationen niedrigschwellig angeboten und leicht verständlich aufbereitet werden. Textbasierte Datenschutzerklärungen sind dabei aber für die meisten Menschen keine geeignete Auskunftsquelle – zu lang, in komplizierter Fachsprache verfasst und schwer auf- findbar. Hersteller und datenverarbeitende Stakeholder ver- lassen sich aktuell dennoch hauptsächlich auf diese sperrige Form der Informationsdarbietung. Die in der Datenschutzgrundverordnung (DSGVO) festgelegten Rechte und Pflichten der Betroffenen und der Datenverarbeiter bleiben ebenfalls oft unklar. Doch wie kann reflektierte Entscheidungsfindung, und damit individuelle digitale Souveränität im Hinblick auf die eigene Nutzung von Wearables und die eigenen Daten gelingen? Welche Alternativen und Innovationen sind denkbar und notwendig? Lassen sich diese auf andere Anwendungsbereiche übertragen? Einblicke und Erkenntnisse dazu aus der dreijährigen Arbeit des Konsortiums InviDas sind in diesem Bericht verfasst.
Characterizing the mean-field dynamo in turbulent accretion disks
Creators: name: Gressel, Oliver
name: Pessah, Martin E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The formation and evolution of a wide class of astrophysical objects is governed by turbulent, magnetized accretion disks. Understanding their secular dynamics is of primary importance. Apart from enabling mass accretion via the transport of angular momentum, the turbulence affects the long-term evolution of the embedded magnetic flux, which in turn regulates the efficiency of the transport. In this paper, we take a comprehensive next step towards an effective mean-field model for turbulent astrophysical disks by systematically studying the key properties of magnetorotational turbulence in vertically-stratified, isothermal shearing boxes. This allows us to infer emergent properties of the ensuing chaotic flow as a function of the shear parameter as well as the amount of net-vertical flux. Using the test-field method, we furthermore characterize the mean-field dynamo coefficients that describe the long-term evolution of large-scale fields. We simultaneously infer the vertical shape and the spectral scale dependence of these closure coefficients, with the latter describing non-local contributions to the turbulent electromotive force. Based on this, we infer a scale-separation ratio of about ten for the large-scale dynamo. We finally determine scaling properties of the mean-field dynamo coefficients. The relevant component of the dynamo α effect is found to scale linearly with the shear rate, as is the corresponding turbulent diffusion, η. Together, these scalings allow us to predict, in a quantitative manner, the cycle period of the well-known butterfly diagram. This lends new support to the importance of the αΩ mechanism in determining the evolution of large-scale magnetic fields in turbulent accretion disks.
description: 15 pages, 13 figures, accepted for publication in ApJ
Epidemiology Beyond Its Limits
Creators: name: Collin, Lindsay
name: Lash, Timothy
name: McCullough, Lauren
name: Amin, Avnika
name: Malik, Amyn
name: Van Dyke, Miriam
name: Marks, Kristin
name: Harrington, Kristin
name: Baliashvili, Davit
name: Stanhope, Kait
name: Labgold, Katie
name: Quader, Zerleen
name: Nelson, Kristin
name: Sarkar, Supriya
name: Brown, Carolyn
name: Haddad, Maryam
name: Holleman, Aaron
name: Shah, Monica
name: Lee, Veronica
name: Hamid, Sarah
name: Freedman, Alexa
Publisher: name: Open Science Framework
Year: 2022

description: The objective of this systematic review is to evaluate the associations described by Gary Taubes in his article "Epidemiology Faces it Limits". We will compile a list of the exposure-outcome relationships mentioned in the article and present the current state of knowledge of those associations.
A Tissue Engineering Acoustophoretic (TEA) Set-up for the Enhanced Osteogenic Differentiation of Murine Mesenchymal Stromal Cells (mMSCs)
Creators: name: Zhang, Hui
name: Beilfuss, Nirina
name: Zabarylo, Urszula
name: Raum, Kay
name: Puts, Regina
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: acoustophoresis
subject: ultrasound
subject: tissue engineering
subject: patterned 3-D construct
subject: mesenchymal stromal cells
subject: osteogenic differentiation
subject: bone regeneration
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Quickly developing precision medicine and patient-oriented treatment strategies urgently require novel technological solutions. The randomly cell-populated scaffolds usually used for tissue engineering often fail to mimic the highly anisotropic characteristics of native tissue. In this work, an ultrasound standing-wave-based tissue engineering acoustophoretic (TEA) set-up was developed to organize murine mesenchymal stromal cells (mMSCs) in an in situ polymerizing 3-D fibrin hydrogel. The resultant constructs, consisting of 17 cell layers spaced at 300 mu m, were obtained by continuous wave ultrasound applied at a 2.5 MHz frequency. The patterned mMSCs preserved the structured behavior within 10 days of culturing in osteogenic conditions. Cell viability was moderately increased 1 day after the patterning; it subdued and evened out, with the cells randomly encapsulated in hydrogels, within 21 days of culturing. Cells in the structured hydrogels exhibited enhanced expression of certain osteogenic markers, i.e., Runt-related transcription factor 2 (RUNX2), osterix (Osx) transcription factor, collagen-1 alpha1 (COL1A1), osteopontin (OPN), osteocalcin (OCN), and osteonectin (ON), as well as of certain cell-cycle-progression-associated genes, i.e., Cyclin D1, cysteine-rich angiogenic inducer 61 (CYR61), and anillin (ANLN), when cultured with osteogenic supplements and, for ANLN, also in the expansion media. Additionally, OPN expression was also augmented on day 5 in the patterned gels cultured without the osteoinductive media, suggesting the pro-osteogenic influence of the patterned cell organization. The TEA set-up proposes a novel method for non-invasively organizing cells in a 3-D environment, potentially enhancing the regenerative properties of the designed anisotropic constructs for bone healing.
Cardiac Monitoring in the Emergency Department
Creators: name: Zègre-Hemsey, Jessica K.
name: Carey, Mary G.
name: Garvey, J. Lee
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Patients present to the emergency department (ED) with a wide range of complaints and ED clinicians are responsible for identifying which conditions are life threatening. Cardiac monitoring strategies in the ED include, but are not limited to, 12-lead electrocardiography and bedside cardiac monitoring for arrhythmia and ischemia detection as well as QT-interval monitoring. ED nurses are in a unique position to incorporate cardiac monitoring into the early triage and risk stratification of patients with cardiovascular emergencies to optimize patient management and outcomes.
La natura delle cose singolari in Spinoza
Creators: name: Godani, Paolo
Publisher: name: Thaumàzein | Rivista di Filosofia
Year: 2022

description: To consider Spinoza a nominalist is a commonplace widespread among scholars. Nevertheless, it is wrong. Not just because Spinoza is without a doubt a realist with regard to a certain sort of universal notions (attributes, for example), but also because the essences of finite modes (res particulares or singulares) are not reducible to individual essences. The thesis I would like to support in this paper is this: the essences of finite modes are neither general nor individual, but “singular”.
description: Thaumàzein | Rivista di Filosofia, Vol. 10 No. 2 (2022): Cosmologia filosofica / Philosophical Cosmology
Sphingolipids in Atherosclerosis: Chimeras in Structure and Function
Creators: name: Peters, Lisa
name: Kuebler, Wolfgang M.
name: Simmons, Szandor
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: cardiovascular disease
subject: atherosclerosis
subject: sphingolipids
subject: ceramide
subject: sphingosine-1-phosphate
subject: dihydrocerammide
subject: lactosylceramide
subject: glucosylceramide
subject: sphingomyelin
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Atherosclerosis-a systemic inflammatory disease-is the number one cause of mortality and morbidity worldwide. As such, the prevention of disease progression is of global interest in order to reduce annual deaths at a significant scale. Atherosclerosis is characterized by plaque formation in the arteries, resulting in vascular events such as ischemic stroke or myocardial infarction. A better understanding of the underlying pathophysiological processes at the cellular and molecular level is indispensable to identify novel therapeutic targets that may alleviate disease initiation or progression. Sphingolipids-a lipid class named after the chimeric creature sphinx-are considered to play a critical and, metaphorically, equally chimeric regulatory role in atherogenesis. Previous studies identified six common sphingolipids, namely dihydroceramide (DhCer), ceramide (Cer), sphingosine-1-phosphate (S1P), sphingomyelin (SM), lactosylceramide (LacCer), and glucosylceramide (GluCer) in carotid plaques, and demonstrated their potential as inducers of plaque inflammation. In this review, we point out their specific roles in atherosclerosis by focusing on different cell types, carrier molecules, enzymes, and receptors involved in atherogenesis. Whereas we assume mainly atheroprotective effects for GluCer and LacCer, the sphingolipids DhCer, Cer, SM and S1P mediate chimeric functions. Initial studies demonstrate the successful use of interventions in the sphingolipid pathway to prevent atherosclerosis. However, as atherosclerosis is a multifactorial disease with a variety of underlying cellular processes, it is imperative for future research to emphasize the circumstances in which sphingolipids exert protective or progressive functions and to evaluate their therapeutic benefits in a spatiotemporal manner.
title: Role of diffusion-weighted magnetic resonance imaging of testes in patients with testicular varicocele
Creators: name: ASOGAN VAISHNAVI, JANANI
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Genital / Reproductive system male
subject: Vascular
subject: Veins / Vena cava
subject: MR-Diffusion/Perfusion
subject: Ultrasound
subject: Ultrasound-Colour Doppler
subject: Diagnostic procedure
subject: Experimental investigations
subject: Comparative studies
subject: Varices

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Varicocele, characterized by varicosity of the pampiniform venous plexus of the spermatic cord, is a common pathology of the testes [1]. Though commonly found in adolescents and young adults (approximately 15% of adult males) the incidence in...
The concept of world and the American Revolution
Creators: name: Gaston, Sean
Publisher: name: Thaumàzein | Rivista di Filosofia
Year: 2022

description: What happens to the concept of world when it is ‘put to work’ in a political event that attempts to constitute a new world? This article uses the American Revolution (1765-1791) to examine the relation between concepts of world and politics. Evoking Kant, whose writings were contemporary with the events in America, and touching on Arendt and Derrida, this essay suggests that the American Revolution relies on a concept of world that is at once geographical and ideal, limited and excessive. The variation of meanings of world in the midst of these political events, especially in the year-long constitutional debates, suggest that the attempt to create a new kind of political world also transformed the traditional concept of world itself. This is not only due to the divided sovereignty that distinguished the new republic; it is also the creation of a political structure that is always more and less than a world.
description: Thaumàzein | Rivista di Filosofia, Vol. 10 No. 2 (2022): Cosmologia filosofica / Philosophical Cosmology
On Gauging Symmetry of Modular Categories
Creators: name: Cui, Shawn X.
name: Galindo, César
name: Plavnik, Julia Yael
name: Wang, Zhenghan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Algebra (math.QA)
subject: FOS: Mathematics

description: Topological order of a topological phase of matter in two spacial dimensions is encoded by a unitary modular (tensor) category (UMC). A group symmetry of the topological phase induces a group symmetry of its corresponding UMC. Gauging is a well-known theoretical tool to promote a global symmetry to a local gauge symmetry. We give a mathematical formulation of gauging in terms of higher category formalism. Roughly, given a UMC with a symmetry group $G$, gauging is a 2-step process: first extend the UMC to a $G$-crossed braided fusion category and then take the equivariantization of the resulting category. Gauging can tell whether or not two enriched topological phases of matter are different, and also provides a way to construct new UMCs out of old ones. We derive a formula for the $H^4$-obstruction, prove some properties of gauging, and carry out gauging for two concrete examples.
description: Final version. To appear in CMP (without the appendix)
title: Peculiarities of tremor-related brain activation in Parkinson’s disease during motion: fMRI study
Creators: name: Omelchenko, Oleksii
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Neuroradiology brain
subject: MR-Functional imaging
subject: Localisation
subject: Geriatrics

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Parkinson's disease (PD) typically manifests with unilateral motor signs and subsequently evolves a number of motor and non-motor symptoms [Hoehn and Yahnr, 2001]. Resting tremor is one of the main Parkinson’s disease (PD) symptoms. Tremor...
Ebola virus disease and critical illness
Creators: name: Jacob, Shevin T.
name: Leligdowicz, Aleksandra
name: Bausch, Daniel G.
name: O'Dempsey, Tim
name: Dickson, Stuart
name: Clement, Christophe
name: Brett-Major, David
name: Fowler, Robert A.
name: Ibrahima, Elhadj
name: Lamah, Marie-Claire
name: Rubinson, Lewis
name: Lyon, G.Marshall
name: Schieffelin, John S.
name: Portella, Gina
name: Jacobs, Michael
name: Lamontagne, Francois
name: Fischer, William A.
name: Hajek, Jan
name: Crozier, Ian
name: Mishra, Sharmistha
name: Shindo, Nikki
name: Adhikari, Neill K.J.
name: Uyeki, Timothy M.
name: Fletcher, Thomas E.
name: Murthy, Srinivas
name: Chan, Adrienne K.
name: Vanderschuren, Abel
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Abstract As of 20 May 2016 there have been 28,646 cases and 11,323 deaths resulting from the West African Ebola virus disease (EVD) outbreak reported to the World Health Organization. There continue to be sporadic flare-ups of EVD cases in West Africa. EVD presentation is nonspecific and characterized initially by onset of fatigue, myalgias, arthralgias, headache, and fever; this is followed several days later by anorexia, nausea, vomiting, diarrhea, and abdominal pain. Anorexia and gastrointestinal losses lead to dehydration, electrolyte abnormalities, and metabolic acidosis, and, in some patients, acute kidney injury. Hypoxia and ventilation failure occurs most often with severe illness and may be exacerbated by substantial fluid requirements for intravascular volume repletion and some degree of systemic capillary leak. Although minor bleeding manifestations are common, hypovolemic and septic shock complicated by multisystem organ dysfunction appear the most frequent causes of death. Males and females have been equally affected, with children (0–14 years of age) accounting for 19 %, young adults (15–44 years) 58 %, and older adults (≥45 years) 23 % of reported cases. While the current case fatality proportion in West Africa is approximately 40 %, it has varied substantially over time (highest near the outbreak onset) according to available resources (40–90 % mortality in West Africa compared to under 20 % in Western Europe and the USA), by age (near universal among neonates and high among older adults), and by Ebola viral load at admission. While there is no Ebola virus-specific therapy proven to be effective in clinical trials, mortality has been dramatically lower among EVD patients managed with supportive intensive care in highly resourced settings, allowing for the avoidance of hypovolemia, correction of electrolyte and metabolic abnormalities, and the provision of oxygen, ventilation, vasopressors, and dialysis when indicated. This experience emphasizes that, in addition to evaluating specific medical treatments, improving the global capacity to provide supportive critical care to patients with EVD may be the greatest opportunity to improve patient outcomes.
title: Manuel de Azevedo Fortes
Creators: name: Conceição, Margarida
Publisher: name: CHAM, Faculdade de Ciências Sociais e Humanas, Universidade NOVA de Lisboa
Year: 2022

description: Entrada biográfica sobre Manuel de Azevedo Fortes, na plataforma eViterbo
description: Conceição, Margarida Tavares da. 2022. Manuel de Azevedo Fortes in eViterbo. CHAM, Faculdade de Ciências Sociais e Humanas, Universidade Nova de Lisboa. eISBN: 978-989-8492-77-7
title: Fourteen-year experience of PAVMs embolisation in patients with hereditary haemorrhagic telangiectasia: what has changed?
Creators: name: Bongiovanni, Simone
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Interventional vascular
subject: Catheter arteriography
subject: CT-Angiography
subject: Embolisation
subject: Arteriovenous malformations
subject: Genetic defects

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Pulmonary Arteriovenous Malformations (PAVMs) are abnormal direct connections between a pulmonary artery and a pulmonary vein. The malformations can manifest as a single focal lesion or as multiple lesions. It is estimated that about 50% of...
Introduction
Creators: name: Russo, Marco
Publisher: name: Thaumàzein | Rivista di Filosofia
Year: 2022

description: Cosmology is the science of the origins and structure of the universe. However, it derives from kosmos, meaning world, and this term indicates both the celestial sphere and the sphere of human history. Cosmology in the philosophical sense must therefore consider both aspects. To this end, I firstly present a semantic exploration that shows the original intertwining of the two spheres. An intertwining that produced a “cosmonomic” canon, where the universe was a physical and metaphysical paradigm for human self-understanding. Then, I show how this paradigm gradually waned with the Copernican scientific revolution, where we witnessed a growing mundanisation, all focused on earthly affairs thanks, in part, to emerging globalisation. The extraordinary richness of the Copernican revolution thus produces a paradoxical worldlessness that disperses the conflicting and enigmatic link between heaven and earth. Hence, the objective of a philosophical cosmology today is to re-propose a unitary Weltfrage capable of reconnecting the various aspects of the experience of the world, inseparably made up of knowledge and imagination, theoretical speculation and crude anthropological realism.
description: Thaumàzein | Rivista di Filosofia, Vol. 10 No. 2 (2022): Cosmologia filosofica / Philosophical Cosmology
title: Reducing metal artefacts in MRI: a retrospective analysis of improved diagnostic quality and reporting confidence without the use of specialised commercial pulses/techniques
Creators: name: Pereira, Claudio
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: MR physics
subject: MR
subject: Image manipulation / Reconstruction
subject: Technical aspects
subject: Imaging sequences
subject: Instrumentation
subject: Artifacts

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Metal-related susceptibility artefacts (MA) are, nowadays, a regular finding in clinical MRI ( Fig. 1 & Fig. 2 ). Their severity can vary wildly depending on implant, field strength used and MRI sequences employed. Modern medical implants are design...
TRAP laws and the invisible labor of US abortion providers
Creators: name: Mercier, Rebecca J.
name: Buchbinder, Mara
name: Bryant, Amy
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Targeted Regulations of Abortion Providers (TRAP laws) are proliferating in the United States and have increased barriers to abortion access. In order to comply with these laws, abortion providers make significant changes to facilities and clinical practices. In this article, we draw attention to an often unacknowledged area of public health threat: how providers adapt to increasing regulation, and the resultant strains on the abortion provider workforce. Current US legal standards for abortion regulations have led to an increase in laws that target abortion providers. We describe recent research with abortion providers in North Carolina to illustrate how providers adapt to new regulations, and how compliance with regulation leads to increased workload and increased financial and emotional burdens on providers. We use the concept of invisible labor to highlight the critical work undertaken by abortion providers not only to comply with regulations, but also to minimize the burden that new laws impose on patients. This labor provides a crucial bridge in the preservation of abortion access. The impact of TRAP laws on abortion providers should be included in the consideration of the public health impact of abortion laws.
Are You Tired of “Us”? Bias and Accuracy in Couples’ Perceptions of Relational Boredom
Creators: name: Dobson, Kiersten
name: Stanton, Sarah
Publisher: name: Open Science Framework
Year: 2022

description: Romantic relationships are typically characterized by many positive experiences; however, over time, partners can fall into a rut and become bored with each other and the relationship (A. Aron & E. N. Aron, 1986; Harasymchuk & Fehr, 2012). These relationships are inherently interdependent (Berscheid, 1999), meaning that partners’ relationship experiences are inevitably linked. Additionally, romantic partners must balance the rewards of having their needs met with the risk of being rejected by one another (Murray, Holmes, & Collins, 2006). Relational boredom may be an informative and unique context for examining dyadic perceptual processes. Are romantic partners able to accurately detect each other’s levels of relational boredom? Are perceivers influenced by their own feelings? Are certain types of people particularly adept (or inept) at accurately perceiving their partner? What are the relationship outcomes associated with boredom knowledge? Knowledge of a partner’s experiences of relational boredom is likely important for navigating intimate relationships; for example, if John recognizes that Claire feels their relationship has lost its spark, he may try to incorporate new types of dates into their routine, which could increase Claire’s satisfaction with the relationship. On the other hand,John may perceive Claire’s boredom as a threat and react less constructively (e.g., by distancing himself from the relationship), which could decrease Claire’s relationship satisfaction. Therefore, whether and how relational boredom is detected and interpreted has the potential to influence relationship dynamics. The relational boredom literature, nonetheless, is in its infancy, and existing research on this topic has not examined partners’ biased and accurate judgments of each other’s boredom. The present study will explore the questions outlined above.
Phytotherapeuthics Affecting the IL-1/IL-17/G-CSF Axis: A Complementary Treatment Option for Hidradenitis Suppurativa?
Creators: name: Witte, Katrin
name: Sabat, Robert
name: Witte-Händel, Ellen
name: Ghoreschi, Kamran
name: Wolk, Kerstin
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: acne inversa
subject: IL-1
subject: IL-17
subject: G-CSF
subject: TNF-alpha
subject: LCN2
subject: neutrophilic granulocytes
subject: polyphenol
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Hidradenitis suppurativa (HS; also designated as acne inversa) is a chronic inflammatory disease characterized by painful skin lesions that occur in the axillary, inguinal, gluteal and perianal areas of the body. These lesions contain recurring deep-seated, inflamed nodules and pus-discharging abscesses and fistulas. Affecting about 1% of the population, this common disease has gained appropriate clinical attention in the last years. Associated with numerous comorbidities including metabolic syndrome, HS is considered a systemic disease that severely impairs the quality of life and shortens life expectancy. Therapeutic options for HS are limited, comprising long-term antibiotic treatment, the surgical removal of affected skin areas, and neutralization of TNF-alpha, the only approved systemic treatment. Novel treatment options are needed to close the therapeutic gap. HS pathogenesis is increasingly better understood. In fact, neutrophilic granulocytes (neutrophils) seem to be decisive for the development of the purulent destructive skin inflammation in HS. Recent findings suggest a key role of the immune mediators IL-1 beta, IL-17A and G-CSF in the migration into and activation of neutrophils in the skin. Although phytomedical drugs display potent immunoregulatory properties and have been suggested as complementary therapy in several chronic disorders, their application in HS has not been considered so far. In this review, we describe the IL-1/IL-17/G-CSF axis and evaluate it as potential target for an integrated phytomedical treatment of HS.
title: Role of Imageology in hydrocephalus. Lets innovate to understand the not so beautiful ‘Sun setting’sign!
Creators: name: Nair, Anirudh
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: CNS
subject: CNS
subject: Neuroradiology brain
subject: CT
subject: MR
subject: MR-Functional imaging
subject: Diagnostic procedure
subject: Shunts
subject: Localisation
subject: Cerebrospinal fluid
subject: Dilatation
subject: Haemodynamics / Flow dynamics

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: •Anatomy of ventricular system, hemodynamic flow pattern of CSF en-route from its production to absorption •Discuss various pathological causes that alters the hemodynamic flow pattern of CSF and the differential causes to be considered...
The expanding repertoire of receptor activity modifying protein (RAMP) function
Creators: name: Matson, Brooke C.
name: Klein, Klara R.
name: Caron, Kathleen M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Receptor activity modifying proteins (RAMPs) associate with G-protein-coupled receptors (GPCRs) at the plasma membrane and together bind a variety of peptide ligands, serving as a communication interface between the extracellular and intracellular environments. The collection of RAMP-interacting GPCRs continues to expand and now consists of GPCRs from families A, B, and C, suggesting that RAMP activity is extremely prevalent. RAMP association with GPCRs can regulate GPCR function by altering ligand binding, receptor trafficking and desensitization, and downstream signaling pathways. Here, we elaborate on these RAMP-dependent mechanisms of GPCR regulation, which provide opportunities for pharmacological intervention.
Bifurcation-based adiabatic quantum computation with a nonlinear oscillator network: Toward quantum soft computing
Creators: name: Goto, Hayato
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The dynamics of nonlinear systems qualitatively change depending on their parameters, which is called bifurcation. A quantum-mechanical nonlinear oscillator can yield a quantum superposition of two oscillation states, known as a Schrödinger cat state, via quantum adiabatic evolution through its bifurcation point. Here we propose a quantum computer comprising such quantum nonlinear oscillators, instead of quantum bits, to solve hard combinatorial optimization problems. The nonlinear oscillator network finds optimal solutions via quantum adiabatic evolution, where nonlinear terms are increased slowly, in contrast to conventional adiabatic quantum computation or quantum annealing, where quantum fluctuation terms are decreased slowly. As a result of numerical simulations, it is concluded that quantum superposition and quantum fluctuation work effectively to find optimal solutions. It is also notable that the present computer is analogous to neural computers, which are also networks of nonlinear components. Thus, the present scheme will open new possibilities for quantum computation, nonlinear science, and artificial intelligence.
description: 8 pages, 3 figures
Studying angle-dependent magnetoresistance oscillations of cuprate superconductors in a model with antiferromagnetic reconstruction and magnetic breakdown
Creators: name: Lewin, Sylvia K.
name: Analytis, James G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We calculate angle-dependent magnetoresistance oscillations (AMRO) for interlayer transport of cuprate superconductors in the presence of ($π,π$) order. The order reconstructs the Fermi surface, creating magnetic breakdown junctions; we show how such magnetic breakdown effects can be incorporated into calculations of interlayer conductivity for this system. We successfully fit experimental data with our model, and these fits suggest a connection between ($π,π$) order and the anisotropic scattering observed in overdoped cuprates. This work paves the way for the use of AMRO as a tool to distinguish different kinds of ordered states.
description: 12 pages, 9 figures
Lumbosacral Transitional Vertebrae Influence on Acetabular Orientation and Pelvic Tilt
Creators: name: Becker, Luis
name: Taheri, Nima
name: Haffer, Henryk
name: Muellner, Maximilian
name: Hipfl, Christian
name: Ziegeler, Katharina
name: Diekhoff, Torsten
name: Pumberger, Matthias
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: LSTV
subject: hip arthroplasty
subject: acetabular version
subject: acetabular inclination
subject: acetabular anteversion
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Lumbosacral transitional vertebrae (LSTV) are common congenital variances with a prevalence found in the population up to 35.6%. The literature demonstrates an influence of LSTV on bony pelvic anatomy. The influence on the anatomical acetabular orientation, which is important for cup positioning in total hip arthroplasty, has not yet been described for patients with LSTV. A total of 53 patients with LSTV were identified from a CT Database including 819 subjects. Fifty patients with LSTV could be included and were matched for age and sex against a control group. We examined the influence of LSTV, classified according to Castellvi, on acetabular orientation and pelvic tilt in the supine position. Functional acetabular anteversion and inclination, assessed against the table plane, were compared against anatomical acetabular anteversion and inclination, assessed against the anterior pelvic plane. The anatomical acetabular inclination correlated with the pelvic tilt (r = 0.363, p < 0.001). The anatomical acetabular inclination was significantly larger than the functional acetabular inclination in the supine position (p < 0.001). Castellvi grading of LSTV correlated negatively with pelvic tilt (rho = -0.387, p = 0.006). Castellvi grading correlated significantly with functional acetabular anteversion (rho = 0.324, p = 0.022) and anatomical acetabular anteversion (rho = 0.306, p = 0.022). A higher Castellvi grading was accompanied by a reduced pelvic tilt in the supine position. The functional acetabular anteversion and anatomical acetabular anteversion increased in parallel to the higher Castellvi grading. Therefore, LSTV and Castellvi grading might be assessed on pre-operative X-rays prior to hip arthroplasty and surgeons might consider adjusting cup positioning accordingly.
L’ultima rivoluzione spaziale globale
Creators: name: Vegetti, Matteo
Publisher: name: Thaumàzein | Rivista di Filosofia
Year: 2022

description: The article explores the concept of the “Global Spatial Revolution” introduced by Schmitt in his Land and Sea (1942) and extends its meaning to a historical and philosophical dimension that looks back to the first space enterprises. Following the cosmological implications of the first and especially of the second space revolution (the one that has air as an element, and no longer the sea), a possible way, alternative to the usual ones, to think about the persistence of modernity in the so-called 'post-modern' age will be discussed. Finally, in dialogue with authors such as Blumenberg, Axelos and Fuller, the genesis of a new worldview will be shown, which I propose to call “planetary thinking”, in order to distinguish it from our recent ecologism.
description: Thaumàzein | Rivista di Filosofia, Vol. 10 No. 2 (2022): Cosmologia filosofica / Philosophical Cosmology
Examining the association between perceived discrimination and heart rate variability in African Americans.
Creators: name: Gray, DeLeon L.
name: Thayer, Julian F.
name: Hill, LaBarron K.
name: Hoggard, Lori S.
name: Richmond, Ashley S.
name: Williams, Dewayne P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Previous research attempting to delineate the role of discrimination in racial/ethnic disparities in hypertension has focused largely on blood pressure, which is chiefly governed by the sympathetic branch of the autonomic nervous system. Consequently, few studies have considered the role of the parasympathetic branch and particularly its regulation of the heart via the vagus nerve.
Clinical Significance of Claudin Expression in Oral Squamous Cell Carcinoma
Creators: name: Zejc, Tatjana
name: Piontek, Jörg
name: Schulzke, Jörg-Dieter
name: Fromm, Michael
name: Ervens, Jürgen
name: Rosenthal, Rita
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: oral squamous cell carcinoma
subject: OSCC
subject: oral cancer
subject: prognosis
subject: reduced survival
subject: claudin
subject: tight junction
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: A change in claudin expression has been demonstrated in various tumors. The present study specifically compares claudin expression in oral squamous cell carcinoma (OSCC) with healthy oral epithelium from the same individual and analyzes the association between claudin expression and the clinically relevant course parameters. Our study includes tissue samples and clinically relevant follow-up data from 60 patients with primary and untreated OSCC. The oral mucosa was analyzed via Western blot for the expression of claudin-1, -2, -3, -4, -5, and -7. Importantly, the tumor and healthy tissues were obtained pairwise from patients, allowing for intraindividual comparisons. Both the healthy and tumor epithelium from the oral cavity did not express the claudin-3 protein. The intraindividual comparison revealed that, in OSCC, claudin-2 expression was higher, and the expression of claudin-4, -5, and -7 was lower than in healthy epithelium. An association was found between increased claudin-2 expression and shorter relapse-free survival. In addition, the reduced expression of claudin-4 had a negative impact on relapse-free survival. Furthermore, associations between the reduced expression of claudin-7 and the stage of a tumor, or the presence of lymph node metastases, were found. Thus, the expression level of claudin-2, -4, and -7 appears to be predictive of the diagnosis and prognosis of OSCC.
Regimi geo-scopici
Creators: name: Morawski, Tommaso
Publisher: name: Thaumàzein | Rivista di Filosofia
Year: 2022

description: By re-adapting the notion of the geoscopic regime introduced by the Italian geographer Eugenio Turri to cartographic visualisation models and geographical imagination, this article aims at laying the foundations for a techno-aesthetics of terrestrial vision. An aesthetics, then, that is not a philosophy of art or a science of beauty, but a critical reflection on the performance of the human aisthesis and its natural tendency to extend itself into artefacts.
description: Thaumàzein | Rivista di Filosofia, Vol. 10 No. 2 (2022): Cosmologia filosofica / Philosophical Cosmology