cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The impact of online reviews on consumer evaluations and decision making: an analysis of review volume and user-generated photos
Creators: name: Lima De Castro Menezes, Matheus
Publisher: name: Imperial College London
Year: 2023

description: This thesis investigates the impact of online social influence on consumer behaviour, specifically within the context of online reviews. It examines how review volume and user-generated photos affect consumer evaluations and decision-making. In Chapter 2, I introduce a novel phenomenon, the N-effect, which explores how opinion volume influences the content of online evaluations. I find that as the number of opinions increases, the content becomes more emotional and less analytical. In Chapter 3, I investigate the role of user-generated photos in shaping purchase intentions. This research demonstrates that photos can enhance review helpfulness, even when they lack diagnostic information. This effect is driven by the confidence signalled by the reviewer when posting a review with a photo, which is later assimilated by readers, leading to increased perceived helpfulness and purchase likelihood. This thesis makes several theoretical and practical contributions to the literature on human interaction with technology. Theoretically, it expands our understanding of online social influence by examining the dynamics of online opinion expression and content. I contribute to the literature on group size by demonstrating how responsibility may be lost in online contexts. Furthermore, the findings provide insights into the social influence of photos on viewers and the role of pseudo-evidence in shaping beliefs and attitudes. From a practical standpoint, this research offers valuable insights for online platform managers and marketers on interpreting and using consumer-written reviews. Overall, this thesis contributes to the existing literature on online social influence and provides insights for businesses to improve communication and interpretation with consumers by better understanding and leveraging online reviews and opinions.
The Cauchy problem for tenth-order thin film equation I. Bifurcation of oscillatory fundamental solutions
Creators: name: Alvarez-Caudevilla, Pablo
name: Evans, Jonathan D.
name: Galaktionov, Victor A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35G20, 35K65, 35K35, 37K50

description: Fundamental global similarity solutions of the tenth-order thin film equation u_{t} = \nabla \cdot(|u|^{n} \n \D^4 u) in R^N \times R_+, where n>0 are studied. The main approach consists in passing to the limit n \to 0^+ by using Hermitian non-self-adjoint spectral theory corresponding to the rescaled linear poly-harmonic equation u_t= \D^5 u in R^N \times \re_+.
description: arXiv admin note: substantial text overlap with arXiv:0911.2996, arXiv:1009.5864
Research Project Management Survey - Question Set
Creators: name: Twohig, Richard
name: Leahy, Emma
name: Wallace, Doireann
Publisher: name: Zenodo
Year: 2022
Subjects: Research Management
Project Management
Survey

description: A survey developed to assess project management modes and capacities in European (EU, EEA, Switzerland and UK) research performing institutes. Dataset from initial survey distribution in 2021; metadata only; dataset may be available for collaboration.
description: .EUS format (for https://ec.europa.eu/eusurvey/) and .PDF of survey questions included
Additional file 2 of PEG@ Carbon Nanotubes Composite as an Effective Nanocarrier of Ixazomib for Myeloma Cancer Therapy
Creators: name: Elgamal, Hanady A.
name: Mohamed, Samah Abdelsabour
name: Farghali, Ahmed A.
name: Hassan, Abeer M. E.
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Hematology

description: Additional file 2. Supplementary tables.
Differential cell responses to nanoparticle docetaxel and small molecule docetaxel at a sub-therapeutic dose range
Creators: name: Werner, Michael E.
name: Sethi, Manish
name: Wang, Andrew Z.
name: Wang, Edina C.
name: Whitehurst, Angelique W.
name: Sinnott, Rebecca
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Current preclinical evaluations of nanoparticle taxanes have focused on the effect of nanoparticle size and shape on the efficacy and toxicity. It is generally assumed that nanoparticle therapeutics have the same cellular response on tumor and normal cells as their small molecule counterparts. Here, we show that nanoparticle taxanes can mediate cellular effects distinct from that of small molecule taxanes at the sub-therapeutic dose range. Cells that are exposed to two polymeric nanoparticle formulations of docetaxel were found to undergo a different cell cycle and cell fate than that of cells that were exposed to small molecule docetaxel. Our results suggest that nanoparticle formulation of therapeutics can affect the therapeutic effect of its cargo.
The Complement of Binary Klein Quadric as a Combinatorial Grassmannian
Creators: name: Saniga, Metod
Publisher: name: arXiv
Year: 2014
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: Given a hyperbolic quadric of PG(5,2), there are 28 points off this quadric and 56 lines skew to it. It is shown that the $(28_6, 56_3)$-configuration formed by these points and lines is isomorphic to the combinatorial Grassmannian of type $G_2(8)$. It is also pointed out that a set of seven points of $G_2(8)$ whose labels share a mark corresponds to a Conwell heptad of PG(5,2). Gradual removal of Conwell heptads from the $(28_6, 56_3)$-configuration yields a nested sequence of binomial configurations identical with part of that found to be associated with Cayley-Dickson algebras (arXiv:1405.6888).
description: 4 pages, 4 tables
M6A RNA methylation in diabetes induced endothelial damage and ischaemic disease
Creators: name: Sweaad, Walid Khalid
Publisher: name: Imperial College London
Year: 2023

description: Diabetes mellitus exposes endothelial cells (ECs) to a chronic hyperglycaemic milieu, leading to dysfunction of the vascular endothelium. The resulting microvasculature rarefaction leads to tissue hypoperfusion and propagates the occurrence of ischaemic events, such as critical limb ischaemia and ischaemic heart disease. Moreover, hyperglycaemia impairs the angiogenic potential of ECs thereby compromising post-ischaemic reparative neovascularisation. N6-methyladenosine (m6A) is emerging as a new layer for fine-tuning gene expression. The functional importance of m6A has been revealed in a plethora of fundamental bioprocesses, while its dysregulation has been linked to several diseases including diabetes. However, our understanding of the precise roles of m6A in the cardiovascular system is still in its infancy and its significance in diabetes associated complications of the vasculature remains completely unexplored. This study elucidates a novel role for METTL3, the primary m6A methylase, in the regulation of angiogenesis. Loss and gain of function studies reveal METTL3 to be crucial in the modulation of EC processes that are conducive to angiogenesis in vitro and in vivo. Mechanistically, METTL3 modulates angiogenesis by mediating the endothelial bioprocessing of the angiogenic miRNAs let-7e and the miR-17-92 cluster. Expressional analysis revealed a dysregulation of m6A and METTL3 in human ECs exposed to diabetic and ischaemic mimicking conditions, ECs derived from a murine model of diabetic LI and in left ventricular tissue and ECs isolated from diabetic mouse hearts. The therapeutic potential of endothelial METTL3 was demonstrated using murine models of diabetic limb ischaemia and myocardial infarction. Here, the adenovirus mediated overexpression of METTL3 in ischaemic limb muscles improved post-ischaemic muscular neovascularisation. Additionally, infarcted hearts treated with Ad.METTL3 showed an increase in arteriole and capillary densities while exhibiting improved contractile function. Thus, the findings in this thesis suggest that the modulation of METTL3 could represent novel therapeutic target for ischaemic complications in diabetic patients.
Meta-analysis of inter-patient pharmacokinetic variability of liposomal and non-liposomal anticancer agents
Creators: name: Zamboni, William C.
name: Schell, Ryan F.
name: White, Taylor F.
name: Walsh, Mark D.
name: Sidone, Brian J.
name: Caron, Whitney P.
name: Ramanathan, Ramesh K.
name: Zamboni, Beth A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: A meta-analysis was conducted to evaluate the inter-patient pharmacokinetic (PK) variability of liposomal and small molecule (SM) anticancer agents.
Research Project Management Survey - Question Set
Creators: name: Twohig, Richard
name: Leahy, Emma
name: Wallace, Doireann
Publisher: name: Zenodo
Year: 2022
Subjects: Research Management
Project Management
Survey

description: A survey developed to assess project management modes and capacities in European (EU, EEA, Switzerland and UK) research performing institutes.
description: .EUS format (for https://ec.europa.eu/eusurvey/) and .PDF included
BVI Photometry and the Red Giant Branch Luminosity Function of M15
Creators: name: Feuillet, Diane K.
name: Paust, Nathaniel E. Q.
name: Chaboyer, Brian
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present new $BVI$ photometry containing 40,000 stars of the Galactic globular cluster M15 (NGC 7078) covering a $25 \times 25$ arcminute area centered on the cluster with a magnitude range from the tip of the Red Giant Branch to three magnitudes below the main sequence turn-off. Using $α$-enhanced Dartmouth Stellar Evolution Program models, we find an age of $13.0 \ \pm \ 1.0$ Gyr and distance modulus of $(m-M)_V = 15.4 \pm 0.1$ through isochrone fitting. Unlike previous works, we find good agreement between the observed completeness-corrected stellar luminosity function and models.
description: 9 pages, 5 figures, 2 tables, accepted for publication in PASP
Maximal breaking of symmetry at critical angle and closed form expression for angular deviations of the Snell law
Creators: name: Araújo, Manoel P.
name: Carvalho, Silvânia A.
name: De Leo, Stefano
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optics (physics.optics)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: A detailed analysis of the propagation of laser gaussian beams at critical angles shows in which conditions it is possible to maximize the breaking of symmetry in the angular distribution and for which values of the laser wavelength and beam waist is possible to find an analytic formula for angular deviations of the Snell law. For propagation throughout $N$ dielectric blocks and for a full breaking of symmetry, overcoming the well known problem of the infinity at critical angle, a closed expression for the Goos-Haenchen shift is obtained. The multiple peaks phenomenon clearly represents an additional evidence of the breaking of symmetry in the angular distribution of optical beams. Finally, laser wavelength and beam waist conditions to produce focal effects in the outgoing beam are also briefly discussed.
description: 18 pages, 2 tables, 6 figures
Analysis of human innate immune responses to PRINT fabricated nanoparticles with cross validation using a humanized mouse model
Creators: name: Guo, Haitao
name: Su, Lishan
name: Ting, Jenny P.-Y.
name: Robbins, Gregory R.
name: Reuter, Kevin
name: Sempowski, Gregory D.
name: Shen, Tammy
name: Roberts, Reid A.
name: McKinnon, Karen P.
name: DeSimone, Joseph M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Ideal nanoparticle (NP)-based drug and vaccine delivery vectors should be free of inherent cytotoxic or immunostimulatory properties. Therefore, determining baseline immune responses to nanomaterials is of utmost importance when designing human therapeutics. We characterized the response of human immune cells to hydrogel NPs fabricated using Particle Replication in Non-wetting Templates (PRINT) technology. We found preferential NP uptake by primary CD14+ monocytes, which was significantly reduced upon PEGylation of the NP surface. Multiplex cytokine analysis of NP treated primary human peripheral blood mononuclear cells (hu-PBMC) suggests that PRINT based hydrogel NPs do not evoke significant inflammatory responses nor do they induce cytotoxicity or complement activation. We furthered these studies using an in vivo humanized mouse model and similarly found preferential NP uptake by human CD14+ monocytes without systemic inflammatory cytokine responses. These studies suggest that PRINT hydrogel particles form a desirable platform for vaccine and drug delivery as they neither induce inflammation nor toxicity.
Kinetic roughening of a soft dewetting line under quenched disorder - a numerical study
Creators: name: Tyukodi, Botond
name: Brechet, Yves
name: Neda, Zoltan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Computational Physics (physics.comp-ph)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: A molecular-dynamics type simulation method, which is suitable for investigating the dewetting dynamics of thin and viscous liquid layers, is discussed. The efficiency of the method is exemplified by studying a two-parameter depinning-like model defined on inhomogeneous solid surfaces. The morphology and the statistical properties of the contact line is mapped in the relevant parameter space, and as a result critical behavior in the vicinity of the depinning transition is revealed. The model allows for the tearing of the layer, which leads to a new propagation regime resulting in non-trivial collective behavior. The large deformations observed for the interface is a result of the interplay between the substrate inhomogeneities and the capillary forces.
description: 12 pages, 10 figures
(:unas) unassigned
Creators: name: (:Unkn) Unknown
Publisher: name: Universita' degli Studi di Salerno
Year: 2024

description: L’articolo identifica il tu delle Stanze con la Luna, individuando una rete di rimandi intertestuali ed evidenziando un sostrato leopardiano. In particolare, Alla sua donna appare dedicata anch’essa al satellite, e si avvicina per certi aspetti alla contemplazione delle Stanze. Nel testo leopardiano, tuttavia, centrale non è il tu della Luna, ma l’io del poeta. La Luna di Montale ha corpo, ha una fisiologia. Leopardi invece parla all’Idea. Per entrambi, l’oscurità senza Luna significa «pazzia», “vaneggiamento”, così come attesta una tradizione plurisecolare.
description: The article identifies the you of the Stanze with the Moon, finding a network of intertextual references and revealing a Leopardian substratum. In particular, Alla sua donna appears also dedicated to the satellite and, in some respects, approaches the contemplation of the Stanze. In Leopardi's text, however, central is not the you of the Moon, but the I of the poet. The Moon of Montale has a body, a physiology. Leopardi, on the other hand, speaks to the Idea. For both, the moonless darkness means «pazzia», “vaneggiamento”, as a centuries-old tradition attests.
Erebaxonopsis Motas & Tanasachi 1947
Creators: name: Smit, Harry
name: Pešić, Vladimir
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Aturidae
Erebaxonopsis

description: Genus Erebaxonopsis Motaş & Tanasachi, 1947
The genus Erebaxonopsis is known thus far from one species from Europe, two species from Japan and one from North America (Cook 1974, K.O. Viets 1987). The record of a new species described below is the first record of the genus from the Oriental region.
description: Published as part of Smit, Harry & Pešić, Vladimir, 2014, Water mites from Mount Kinabalu and the Crocker Range, Borneo, Malaysia (Acari: Hydrachnidia), with the description of 34 new species, pp. 1-71 in Zootaxa 3876 (1) on page 58, DOI: 10.11646/zootaxa.3876.1.1, http://zenodo.org/record/287281
The snag bag: a new method for sampling macroinvertebrate communities on large woody debris
Creators: name: Growns, J. E
name: King, A. J
name: Betts, F. M
Publisher: name: La Trobe
Year: 2023

description: La Trobe University Faculty of Science, Technology and Engineering Murray Darling Freshwater Research Centre

MDFRC item.

Sampling macroinvertebrate communities from natural snags (large woody debris) is difficult, particularly in southeastern Australia where the predominant river red gum snags are very large and heavy. This makes removal of natural snags impractical. The Snag Bag is a new method for sampling macroinvertebrates from natural snags. It consists of a 250 m mesh bag with the sides closed by Velcro. When opened out, one side of the Snag Bag can be passed under the snag and the bag is then closed around the snag, before brushing the surface down to remove invertebrates. The Snag Bag is removed from the snag by loosening the Velcro above the snag and closing it below, until the bag has almost been removed. The bag is then quickly pulled from the snag and out of the water. Snags with diameters of 5–30 cm at depths of up to about 50 cm can be sampled. The Snag Bag was trialed in two lowland rivers in south-eastern Australia. Repeated sampling showed that its efficiency was about 96%, comparing very favourably with other methods of collecting macroinvertebrates in streams. Its efficiency was not affected by current speed or the surface area sampled. A subsampling procedure was developed and tested, as whole samples were often extremely large. A proportion of the sample equivalent to a set surface area (0.05 m2) was sorted. If fewer than 300 animals were obtained, further known percentages of the original sample were processed fully, until 300 animals had been removed. The Snag Bag provided quantitative data that allowed discrimination between densities of invertebrates on snags at two different sites on the same river.
Polysilsesquioxane nanoparticles for triggered release of cisplatin and effective cancer chemoradiotherapy
Creators: name: Wang, Andrew Z.
name: Cummings, Natalie D.
name: Lin, Wenbin
name: Werner, Michael E.
name: Rocca, Joseph Della
name: Vivero-Escoto, Juan L.
name: Huxford-Phillips, Rachel C.
name: Kramer, Stephanie A.
name: Sukumar, Rohit
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Chemoradiotherapy is a well-established treatment paradigm in oncology. There has been strong interest in identifying strategies to further improve its therapeutic index. An innovative strategy is to utilize nanoparticle (NP)chemotherapeutics in chemoradiation. Since the most commonly utilized chemotherapeutic with radiotherapy is cisplatin, the development of a NP cisplatin for chemoradiotherapy has the highest potential impact on this treatment. Here, we report the development of a NP comprised of polysilsesquioxane (PSQ) polymer crosslinked by a cisplatin prodrug (Cisplatin-PSQ) and its utilization in chemoradiotherapy using non-small cell lung cancer as a disease model. Cisplatin-PSQ NP has an exceptionally high loading of cisplatin. Cisplatin-PSQ NPs were evaluated in chemoradiotherapy in vitro and in vivo. They demonstrated significantly higher therapeutic efficacy when compared to cisplatin. These results suggest that the Cisplatin-PSQ NP holds potential for clinical translation in chemoradiotherapy.
Nanomedicinal strategies to treat multidrug-resistant tumors: current progress
Creators: name: Mumper, Russell J
name: Dong, Xiaowei
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Multidrug resistance (MDR) is a major impediment to the success of cancer chemotherapy. P-glycoprotein is an important and the best-known membrane transporter involved in MDR. Several strategies have been used to address MDR, especially P-glycoprotein-mediated drug resistance in tumors. However, clinical success has been limited, largely due to issues regarding lack of efficacy and/or safety. Nanoparticles have shown the ability to target tumors based on their unique physical and biological properties. To date, nanoparticles have been investigated primarily to address P-glycoprotein and the observed improved anticancer efficacy suggests that nanomedicinal strategies provide a new opportunity to overcome MDR. This article focuses on nanotechnology-based formulations and current nanomedicine approaches to address MDR in tumors and discusses the proposed mechanisms of action.
Rapid transport of muco-inert nanoparticles in cystic fibrosis sputum treated with N -acetyl cysteine
Creators: name: Dawson, Michelle R
name: Hanes, Justin
name: Lai, Samuel K
name: Boylan, Nicholas J
name: Boyle, Michael P
name: Suk, Jung Soo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Sputum poses a critical diffusional barrier that strongly limits the efficacy of drug and gene carriers in the airways of individuals with cystic fibrosis (CF). Previous attempts to enhance particle penetration of CF sputum have focused on either reducing its barrier properties via mucolytics, or decreasing particle adhesion to sputum constituents by coating the particle surface with non-mucoadhesive polymers, including polyethylene glycol (PEG). Neither approach has enabled particles to penetrate expectorated sputum at rates previously observed for non-mucoadhesive nanoparticles in human cervicovaginal mucus. Here, we sought to investigate whether a common mucolytic, N-acetyl cysteine (NAC), in combination with dense PEG coatings on particles, can synergistically enhance particle penetration across fresh undiluted CF sputum.
Efficient boundary integral solution for acoustic wave scattering by irregular surfaces
Creators: name: Spivack, Orsola Rath
name: Spivack, Mark
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: The left-right operator splitting method is studied for the efficient calculation of acoustic fields scattered by arbitrary rough surfaces. Here the governing boundary integral is written as a sum of left- and right-going components, and the solution expressed as an iterative series, expanding about the predominant direction of propagation. Calculation of each term is computationally inexpensive both in time and memory, and the field is often accurately captured using one or two terms. The convergence and accuracy are examined by comparison with exact solution for smaller problems, and a series of much larger problems are tackled. The method is also immediately applicable to other scatterers such as waveguides, of which examples are given.
Characterization of biomolecular nanoconjugates by high-throughput delivery and spectroscopic difference
Creators: name: Jones, Brooke
name: Risor, Azure
name: Sedaghat-Herati, Reza
name: Ruff, Michael
name: Kanomata, Masaaki
name: DeLong, Robert K
name: Fallon, John K
name: Williams, Joseph
name: Witkowski, Colette
name: Warner, Mathew
name: Garrad, Richard
name: Zimmerman, Scott D
name: Laymon, Amanda
name: Hickey, Anthony J
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Nanoparticle conjugates have the potential for delivering siRNA, splice-shifting oligomers or nucleic acid vaccines, and can be applicable to anticancer therapeutics. This article compares tripartite conjugates with gold nanoparticles or synthetic methoxypoly(ethylene glycol)-block-polyamidoamine dendrimers.
SOPHIE velocimetry of Kepler transit candidates. XIII. KOI-189 B and KOI-686 B: two very low-mass stars in long-period orbits
Creators: name: Díaz, R. F.
name: Montagnier, G.
name: Leconte, J.
name: Bonomo, A. S.
name: Deleuil, M.
name: Almenara, J. M.
name: Barros, S. C. C.
name: Bouchy, F.
name: Bruno, G.
name: Damiani, C.
name: Hébrard, G.
name: Moutou, C.
name: Santerne, A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We present the radial-velocity follow-up of two Kepler planetary transiting candidates (KOI-189 and KOI-686) carried out with the SOPHIE spectrograph at the Observatoire de Haute Provence. These data promptly discard these objects as viable planet candidates and show that the transiting objects are in the regime of very low-mass stars, where a strong discrepancy between observations and models persists for the mass and radius parameters. By combining the SOPHIE spectra with the Kepler light curve and photometric measurements found in the literature, we obtain a full characterization of the transiting companions, their orbits, and their host stars. The two companions are in significantly eccentric orbits with relatively long periods (30 days and 52.5 days), which makes them suitable objects for a comparison with theoretical models, since the effects invoked to understand the discrepancy with observations are weaker for these orbital distances. KOI-189 B has a mass M = 0.0745 +/- 0.0033 Msun and a radius R = 0.1025 +/- 0.0024 Rsun. The density of KOI-189 B is significantly lower than expected from theoretical models for a system of its age. We explore possible explanations for this difference. KOI-189 B is the smallest hydrogen-burning star with such a precise determination of its fundamental parameters. KOI-686 B is larger and more massive (M = 0.0915 +/- 0.0043 Msun; R = 0.1201 +/- 0.0033 Rsun), and its position in the mass-radius diagram agrees well with theoretical expectations.
description: Accepted for publication in Astronomy and Astrophysics. 13 pages, 5 figures. Series numbering modified by editorial request. Removed boldface markings
CHSH inequality: Quantum probabilities as classical conditional probabilities
Creators: name: Khrennikov, Andrei
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Probability (math.PR)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: The celebrating theorem of A. Fine implies that the CHSH inequality is violated if and only if the joint probability distribution for the quadruples of observables involved the EPR-Bohm-Bell experiment does not exist, i.e., it is impossible to use the classical probabilistic model (Kolmogorov, 1933). In this note we demonstrate that, in spite of Fine's theorem, the results of observations in the EPR-Bohm-Bell experiment can be described in the classical probabilistic framework. However, the "quantum probabilities" have to be interpreted as conditional probabilities, where conditioning is with respect to fixed experimental settings. Our approach is based on the complete account of randomness involved in the experiment. The crucial point is that randomness of selections of experimental settings has to be taken into account. This approach can be applied to any complex experiment in which statistical data are collected for various (in general incompatible) experimental settings. Finally, we emphasize that our construction of the classical probability space for the EPR-Bohm-Bell experiment cannot be used to support the hidden variable approach to the quantum phenomena. The classical random parameter $ω$ involved in our considerations cannot be identified with the hidden variable $λ$ which is used the Bell-type considerations.
description: presented at the conference Quantum Theory: from Problems to Applications, Vaxjo, Sweden, June 2014, and during the course of lectures on inter-relation between classical and quantum randomness given at Institute for Quantum Optics and Quantum Information of Austrian Academy of Science, May 2014
Bench-to-bedside translation of magnetic nanoparticles
Creators: name: Kabanov, Alexander V
name: Gendelman, Howard E
name: Singh, Dhirender
name: McMillan, JoEllyn M
name: Sokolsky-Papkov, Marina
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Magnetic nanoparticles (MNPs) are a new and promising addition to the spectrum of biomedicines. Their promise revolves around the broad versatility and biocompatibility of the MNPs and their unique physicochemical properties. Guided by applied external magnetic fields, MNPs represent a cutting-edge tool designed to improve diagnosis and therapy of a broad range of inflammatory, infectious, genetic and degenerative diseases. Magnetic hyperthermia, targeted drug and gene delivery, cell tracking, protein bioseparation and tissue engineering are but a few applications being developed for MNPs. MNPs toxicities linked to shape, size and surface chemistry are real and must be addressed before clinical use is realized. This article presents both the promise and perils of this new nanotechnology, with an eye towards opportunity in translational medical science.
The discovery and validation of metabolites as candidate biomarkers for the diagnosis of hepatocellular carcinoma
Creators: name: U, Mei Ran Abellona
Publisher: name: Imperial College London
Year: 2019

description: Hepatocellular carcinoma (HCC) constitutes a major disease burden worldwide. Much of its high mortality-to-incidence ratio can be attributed to late diagnosis, resulting in poor survival. Motivated by the need to develop a novel non-invasive diagnostic test to improve the chances of early diagnosis, this thesis makes use of metabonomic technologies to discover and validate metabolites as potential novel diagnostic markers for HCC. First, a systematic review of the literature on the topic was conducted to collate all published evidence of metabolites that were reported to be discriminatory for HCC. A bespoke risk of bias assessment tool was developed for metabonomic studies and a weighted score system was implemented to rank metabolites based on the strength of evidence. This resulted in a ranked list of metabolites with the greatest potential to be followed up for validation for each of the sample types (tissue, blood and urine). Then, validation of urinary metabolites with the greatest potential concluded from the systematic review was performed using data acquired from a UK cohort. None of the previously reported difference between HCC and cirrhosis groups could be reproduced, indicating the current lack of candidate markers specific for HCC detectable in urine. Finally, an exploratory analysis of serum 1H-NMR data from a UK and a Nigerian cohort was performed. Common and different alterations in metabolite levels between the two cohorts were compared. Glutamine-to-glutamate ratio was identified as a potential marker with the best discriminatory power between HCC and cirrhosis patients and this was validated using an independent cohort from the Gambia. This work adds to the ongoing effort to elucidate metabolites with the best potential to be further validated with the goal of developing a novel diagnostic test for HCC.
Induced Coherence, Vacuum Fields, and Complementarity in Biphoton Generation
Creators: name: Heuer, A.
name: Menzel, R.
name: Milonni, P. W.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We describe spontaneous parametric down-conversion experiments in which induced coherence across two coupled interferometers results in high-visibility single-photon interference. Opening additional photon channels allows "which-path" information and reduces the visibility of the singlephoton interference, but results in nearly perfect visibility when photons are counted in coincidence. A simplified theoretical model accounts for these complementary observations and attributes them directly to the relations among the vacuum fields at the different crystals.
description: 4 pages, 5 figures
title: Η φορολογία στην Ελλάδα από την κρίση και μετά
title: Taxation in Greece from the crisis onwards
titleType: AlternativeTitle
Creators: name: Καλογερέση, Χριστίνα
Publisher: name: Πανεπιστήμιο Πελοποννήσου
Year: 2023
Subjects: subject: Οικονομική ύφεση -- Ελλάδα
subject: Φορολογία -- Δίκαιο και νομοθεσία -- Ελλάδα
subject: Φορολογία
subject: Οικονομική κρίση
subject: Αποτελεσματικότητα
subject: Φοροδιαφυγή
subject: Επιχειρηματικότητα
subject: Κίνητρα
subject: Taxation
subject: Economic crisis
subject: Efficiency
subject: Tax evasion
subject: Entrepreneurship
subject: Incentives

description: Μ.Δ.Ε. 11
description: Σκοπός της παρούσας Διπλωματικής Εργασίας είναι να μελετήσει την φορολογία στην Ελλάδα από την περίοδο της κρίσης και μετέπειτα. Ειδικότερα, η εργασία επικεντρώνεται στην έννοια του φορολογικού συστήματος, ενώ στη συνέχεια εξετάζει αναλυτικά την φορολογία φυσικών και νομικών προσώπων. Στα πλαίσια μελέτης της φορολογίας φυσικών και νομικών προσώπων δίνεται έμφαση στις αλλαγές που έλαβαν χώρα κατά τη διάρκεια των ετών της κρίσης, καθώς επίσης και στην αποτελεσματικότητα του φορολογικού συστήματος, ενώ ταυτόχρονα παρουσιάζονται και ορισμένες καλές πρακτικές αναμόρφωσης των φορολογικών συστημάτων. Επιπρόσθετα, διερευνάται η έννοια της φοροδιαφυγής, της φοροαποφυγής, ενώ έμφαση δίνεται στην φοροδιαφυγή στην Ελλάδα όπου παρουσιάζονται και ποσοτικά στοιχεία. Τέλος, εξετάζεται ο ρόλος που μπορεί να διαδραματίσει η φορολογία στην ενίσχυση της επιχειρηματικότητας, παρουσιάζοντας κυρίως πρόσφατες παρεμβάσεις ενίσχυσης της επιχειρηματικότητας μέσω των ευνοϊκών φορολογικών συνθηκών. Όσον αφορά τη μεθοδολογία που χρησιμοποιείται στην παρούσα Διπλωματική Εργασία, αφορά την εκτενή βιβλιογραφική αναζήτηση σε βάσεις επιστημονικών δεδομένων όπως είναι το Google Scholar, όπου μελετήθηκαν επιστημονικά άρθρα που αφορούν τη φορολογία, ενώ ακόμη χρησιμοποιήθηκαν και αντίστοιχα επιστημονικά συγγράμματα. Επιπρόσθετα, έγινε χρήση μελετών που αφορούν ζητήματα φορολογίας, φοροδιαφυγής κτλ, δίνοντας έμφαση στην περίπτωση της Ελλάδος. Τέλος, αξιοποιήθηκαν και εκτενείς πληροφορίες από το διαδίκτυο, έτσι ώστε η όλη προσέγγιση του ζητήματος να είναι όσο το δυνατόν πιο επικαιροποιημένη.
Washing out of the 0-pi transition in Josephson junctions
Creators: name: Avriller, Remi
name: Pistolesi, Fabio
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We consider a Josephson junction formed by a quantum dot connected to two bulk superconductors in presence of Coulomb interaction and coupling to both an electromagnetic environment and a finite density of electronic quasi-particles. In the limit of large superconducting gap we obtain a Born-Markov description of the system dynamics. We calculate the current-phase relation and we find that the experimentally unavoidable presence of quasi-particles can dramatically modify the 0-pi standard transition picture. We show that photon-assisted quasi-particles absorption allows the dynamic switching from the 0- to the pi-state and vice-versa, washing out the 0-pi transition predicted by purely thermodynamic arguments.
description: 5 pages, 2 figures
Formulation design facilitates magnetic nanoparticle delivery to diseased cells and tissues
Creators: name: Sokolsky-Papkov, Marina
name: Vishwasrao, Hemant M
name: Liu, Xin-Ming
name: McMillan, JoEllyn M
name: Singh, Dhirender
name: Kabanov, Alexander V
name: Gendelman, Howard E
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Magnetic nanoparticles (MNPs) accumulate at disease sites with the aid of magnetic fields; biodegradable MNPs can be designed to facilitate drug delivery, influence disease diagnostics, facilitate tissue regeneration and permit protein purification. Because of their limited toxicity, MNPs are widely used in theranostics, simultaneously facilitating diagnostics and therapeutics. To realize therapeutic end points, iron oxide nanoparticle cores (5–30 nm) are encapsulated in a biocompatible polymer shell with drug cargos. Although limited, the toxic potential of MNPs parallels magnetite composition, along with shape, size and surface chemistry. Clearance is hastened by the reticuloendothelial system. To surmount translational barriers, the crystal structure, particle surface and magnetic properties of MNPs need to be optimized. With this in mind, we provide a comprehensive evaluation of advancements in MNP synthesis, functionalization and design, with an eye towards bench-to-bedside translation.
Macrophages offer a paradigm switch for CNS delivery of therapeutic proteins
Creators: name: Haney, Matthew J
name: Gendelman, Howard E
name: Mahajan, Vivek
name: Mosley, R Lee
name: Kabanov, Alexander V
name: Batrakova, Elena V
name: Suresh, Poornima
name: Hingtgen, Shawn D
name: Manickam, Devika S
name: Zhao, Yuling
name: Klyachko, Natalia L
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Active targeted transport of the nanoformulated redox enzyme, catalase, in macrophages attenuates oxidative stress and as such increases survival of dopaminergic neurons in animal models of Parkinson’s disease. Optimization of the drug formulation is crucial for the successful delivery in living cells. We demonstrated earlier that packaging of catalase into a polyion complex micelle (‘nanozyme’) with a synthetic polyelectrolyte block copolymer protected the enzyme against degradation in macrophages and improved therapeutic outcomes. We now report the manufacture of nanozymes with superior structure and therapeutic indices.
The effects of nanoparticle drug loading on the pharmacokinetics of anticancer agents
Creators: name: Petschauer, Jennifer S
name: Kirschbrown, Whitney P
name: Zamboni, William C
name: Song, Gina
name: Madden, Andrew J
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Major advances in carrier-mediated agents, which include nanoparticles, nanosomes and conjugates, have revolutionized drug delivery capabilities over the past decade. While providing numerous advantages, such as greater solubility, duration of exposure and delivery to the site of action over their small-molecule counterparts, there is substantial variability in systemic clearance and distribution, tumor delivery and pharmacologic effects (efficacy and toxicity) of these agents. This review provides an overview of factors that affect the pharmacokinetics and pharmacodynamics of carrier-mediated agents in preclinical models and patients.
Additional file 3 of Adapting field-mosquito collection techniques in a perspective of near-infrared spectroscopy implementation
Creators: name: Somé, Bernard Mouonniba
name: Da, Dari F.
name: McCabe, Ruth
name: Djègbè, Nicaise Denis C.
name: Paré, Lawata Inès Géraldine
name: Wermé, Kadidia
name: Mouline, Karine
name: Lefèvre, Thierry
name: Ouédraogo, Anicet Georges
name: Churcher, Thomas S.
name: Dabiré, Roch Kounbobr
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 3: Figure S1. Average spectra of laboratory-reared mosquitoes for each killing method: chloroform (blue) and Kaltox (red). Average spectra differed slightly between the two killing options.
Combining observational techniques to constrain convection in evolved massive star models
Creators: name: Georgy, C.
name: Saio, H.
name: Meynet, G.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Recent stellar evolution computations indicate that massive stars in the range ~ 20 - 30 Msun are located in the blue supergiant (BSG) region of the Hertzsprung-Russell diagram at two different stages of their life: immediately after the main sequence (MS, group 1) and during a blueward evolution after the red supergiant phase (group 2). From the observation of the pulsationnal properties of a subgroup of variable BSGs (alpha Cyg variables), one can deduce that these stars belongs to group 2. It is however difficult to simultaneously fit the observed surface abundances and gravity for these stars, and this allows to constrain the physical processes of chemical species transport in massive stars. We will show here that the surface abundances are extremely sensitive to the physics of convection, particularly the location of the intermediate convective shell that appears at the ignition of the hydrogen shell burning after the MS. Our results show that the use of the Ledoux criterion to determine the convective regions in the stellar models leads to a better fit of the surface abundances for alpha Cyg variables than the Schwarzschild one.
description: 5 pages, 2 figures, to appear in IAUS 307 proceedings
A self-calibrating optomechanical force sensor with femtonewton resolution
Creators: name: Melcher, John
name: Stirling, Julian
name: Cervantes, Felipe Guzman
name: Pratt, Jon R.
name: Shaw, Gordon A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We report the development of an ultrasensitive optomechanical sensor designed to improve the accuracy and precision of force measurements with atomic force microscopy. The sensors reach quality factors of 4.3x10^6 and force resolution on the femtonewton scale at room temperature. Self-calibration of the sensor is accomplished using radiation pressure to create a reference force. Self-calibration enables in situ calibration of the sensor in extreme environments, such as cryogenic ultra-high vacuum. The senor technology presents a viable route to force measurements at the atomic scale with uncertainties below the percent level.
Direct observation of a single nanoparticle–ubiquitin corona formation
Creators: name: Radic, Slaven
name: Brown, Jared M.
name: Ding, Feng
name: Chen, Pengyu
name: Chen, Ran
name: Geitner, Nicholas K.
name: Ke, Pu Chun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The advancement of nanomedicine and the increasing applications of nanoparticles in consumer products have led to administered biological exposure and unintentional environmental accumulation of nanoparticles, causing concerns over the biocompatibility and sustainability of nanotechnology. Upon entering physiological environments, nanoparticles readily assume the form of a nanoparticle-protein corona that dictates their biological identity. Consequently, understanding the structure and dynamics of nanoparticle-protein corona is essential for predicting the fate, transport, and toxicity of nanomaterials in living systems and for enabling the vast applications of nanomedicine. Here we combined multiscale molecular dynamics simulations and complementary experiments to characterize the silver nanoparticle-ubiquitin corona formation. Notably, ubiquitins competed with citrates for the nanoparticle surface, governed by specific electrostatic interactions. Under a high protein/nanoparticle stoichiometry, ubiquitins formed a multi-layer corona on the particle surface. The binding exhibited an unusual stretched-exponential behavior, suggesting a rich binding kinetics. Furthermore, the binding destabilized the α-helices while increasing the β-sheets of the proteins. This study revealed the atomic and molecular details of the structural and dynamic characteristics of nanoparticle-protein corona formation.
Response theory and critical phenomena for noisy interacting systems
Creators: name: Zagli, Niccolo
Publisher: name: Imperial College London
Year: 2022

description: In this thesis we investigate critical phenomena for ensembles of identical interacting agents, namely weakly interacting diffusions. These interacting systems undergo two qualitatively different scenarios of criticality, critical transitions and phase transitions. The former situation conforms to the classical tipping point phenomenology that is observed in finite dimensional systems and originates from a setting where negative feedbacks that stabilise the system progressively loose their efficiency, resulting in amplified fluctuations and correlation properties of the system. On the other hand, \textit{phase transitions} stem from the complex interplay between the agents' own dynamics, the coupling among them and the noise, leading to macroscopic emergent behaviour of the system, and are only observed in the thermodynamic limit. Classically, \textit{phase transitions} are investigated with the use of suitable macroscopic variables, called order parameters, acting as effective reaction coordinates that capture the relevant features of the macroscopic dynamics. However, identifying an order parameter is not always possible. In this thesis we adopt a complementary point of view, based on Linear Response theory, to investigate such critical phenomena. We are able to identify the conditions leading either to a critical transition or a phase transition in terms of spectral properties of suitable response operators. We associate critical phenomena to settings where the response of the system breaks down. In particular, we are able to characterise these critical scenarios as settings where the complex valued susceptibility of the system develops a non analytical behaviour for real values of frequencies, resulting in a macroscopic resonance of the system. We provide multiple paradigmatic examples of equilibrium and nonequilibrium phase transitions where we are able to prove mathematically and numerically the clear signature of a singular behaviour of the susceptibility at the phase transition as the thermodynamic limit is reached. Being associated to spectral properties of suitable operators describing either correlation or response properties, these resonant phenomena do not depend on the specific details of the applied forcing nor on the observable under investigation, allowing one to bypass the problem of the identification of the order parameter for the system.
Additional file 4 of Adapting field-mosquito collection techniques in a perspective of near-infrared spectroscopy implementation
Creators: name: Somé, Bernard Mouonniba
name: Da, Dari F.
name: McCabe, Ruth
name: Djègbè, Nicaise Denis C.
name: Paré, Lawata Inès Géraldine
name: Wermé, Kadidia
name: Mouline, Karine
name: Lefèvre, Thierry
name: Ouédraogo, Anicet Georges
name: Churcher, Thomas S.
name: Dabiré, Roch Kounbobr
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 4: Figure S2. Average spectra of laboratory-reared mosquitoes for each killing and preservation method: fresh mosquitoes (blue) and preserved mosquitoes (red). Globally, a distinctive difference was observed between the average spectra from mosquitoes freshly analyzed compared to those obtained after Anopheles preservation in silica gel or in ethanol. However, mosquito NIRS spectra were influenced more by the silica gel than by ethanol.