cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Ultra-sensitive hexagonal PCF-SPR sensor with a broad detection range
Creators: name: Liu, Wei
name: Hu, Chunjie
name: Zhou, Lei
name: Yi, Zao
name: Liu, Chao
name: Lv, Jingwei
name: Yang, Lin
name: Chu, Paul K.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: A photonic crystal fibre (PCF) sensor based on surface plasmon resonance (SPR) with a hexagonal structure and external gold coating is designed and demonstrated to have a broad detection range and ultra-high sensitivity. Gold is chosen as the plasmonic materials due to the inert and stable chemical properties and the gold coating on the PCF-SPR sensor also simplifies the detection and fabrication processes. The sensing properties are analysed by the finite element method (FEM). In this sensor, the y-polarized mode with the large mode field area shows better performance such as the high spectral sensitivity of 28,700 nm/RIU, wide analyte refractive index (RI) range from 1.28 to 1.43, resolution of 3.48×10-6 RIU, and maximum amplitude sensitivity of 2481.06 RIU−1. Furthermore, the paragon figure of merit and signal-to-noise ratio of the sensor are 517.81 RIU−1 and 5.18, respectively.
MOESM1 of The malaria testing and treatment landscape in Kenya: results from a nationally representative survey among the public and private sector in 2016
Creators: name: Musuva, Anne
name: Waqo Ejersa
name: Kiptui, Rebecca
name: Memusi, Dorothy
name: Abwao, Edward
Publisher: name: figshare
Year: 2017
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Computational Biology

description: Additional file 1. Detailed sample description.
High Mass X-ray Binaries and the Cosmic 21-cm Signal: Impact of Host Galaxy Absorption
Creators: name: Das, Arpan
name: Mesinger, Andrei
name: Pallottini, Andrea
name: Ferrara, Andrea
name: Wise, John H.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: By heating the intergalactic medium (IGM) before reionization, X-rays are expected to play a prominent role in the early Universe. The cosmic 21-cm signal from this "Epoch of Heating" (EoH) could serve as a clean probe of high-energy processes inside the first galaxies. Here we improve on prior estimates of this signal by using high-resolution hydrodynamic simulations to calculate the X-ray absorption due to the interstellar medium (ISM) of the host galaxy. X-rays absorbed inside the host galaxy are unable to escape into the IGM and contribute to the EoH. We find that the X-ray opacity through these galaxies can be approximated by a metal-free ISM with a typical column density of log[N / cm^-2] = 21.4 +0.40-0.65. We compute the resulting 21-cm signal by combining these ISM opacities with public spectra of high-mass X-ray binaries (thought to be important X-ray sources in the early Universe). Our results support "standard scenarios" in which the X-ray heating of the IGM is inhomogeneous, and occurs before the bulk of reionization. The large-scale (k ~ 0.1/Mpc) 21-cm power reaches a peak of ~100 mK^2 at z = 10 - 15, with the redshift depending on the cosmic star formation history. This is in contrast to some recent work, motivated by the much larger X-ray absorption towards local HMXBs inside the Milky Way. Our main results can be reproduced by approximating the X-ray emission from HMXBs with a power-law spectrum with energy index alpha = 1, truncated at energies below 0.5 keV.
description: 9 pages, 8 figures, submitted to MNRAS
Lettre de Bénigne Legouz de Gerland à Jean-François Séguier,
Creators: name: Legouz de Gerland, Bénigne
name: Bénigne Legouz De Gerland
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021
Subjects: Antiquités (général)
Botanique

description: [transcription] Monsieur de Migieu, Monsieur, homme d'esprit, ancien officier au garde et chevalier de Saint-Louis, charmé de votre réputation si bien méritée et par le récit que je lui ai fait des qualités de votre coeur est tombé subitement amoureux de vous et me prie de vous rendre sa lettre. Il fait souvent son séjour à Paris et vient six mois en c epays dans ses terres avec sa femme. Il a fait une grande récolte de bronze, surtout en lampes sépulcrales dont il a une ample collection. Il a de plus ramassé autour de ses terres beaucoup de monuments antiques [fol. 227 v] dans le goût de celle que j'ai donnée. Je lui ai encore conseillé de les faire graver mais il m'a dit qu'il avait des enfants. Nous verrons, quelle part nous prendrons. Je vous envoie sa lettre à laquelle nous fimes répondre à son hôtel à Dijon. Il est ami du chanoine Gandelot qui s'est lourdement trompé dans son histoire de Beaune. Une critique qui le redresse est nécessaire à sa réputation et à celle d'un écrivain de la province. J'avais dessein de lui faire passer vos remarques là-dessus par Monsieur de Migieu.

J'en voulais tirer une note, mais j'ai égaré ou brûlé sans y penser votre lettre. Je vous prie de m'envoyer un duplicata de vos remarques pour les lui faire passer et vous lui rendrez un grand service parce que je crois [fol. 228 r] qu'il continue encore les mêmes sujets. Je ferai passer par Monsieur de Migieu vos remarques, ce dernier a trouvé les traces d'un gibet dans les montagnes. Les laves subsistent encore et il est une tradition dans le pays que le village de Volnay ne porte ce nom que par des restes des volcans. c'est une chose à éclaircir.

Notre botanique va assez bien moyennant vos charités et j'attends d'Angleterre beaucoup de plantes curieuses. Si l'on me tient parole et je compte que nous ferons un catalogue, cet été, imprimé du commencement de nos richesses, vous l'aurez. Vous verrez s'il y a quelque chose que vous désirez. Vous ordonnerez et vous serez servi, trop heureux de trouver les occasions de vous marquer votre reconnaissance et les sentiments respectables avec lesquelles je serai toujours, Mon cher Monsieur, votre très humble.

Legouz Gerland
description: [personnes citées] Anthelme Michel Laurent de Migieu
description: Source: [lieu de Conservation] Nîmes, Bibliothèque Carré d'Art [cote]ms. 143_8, fol. 227-228
description: Source: ark:/12148/btv1b10015232k
description: created: 0000-00-00
ALMA Observations of Starless Core Substructure in Ophiuchus
Creators: name: Kirk, Helen
name: Dunham, Michael M.
name: Di Francesco, James
name: Johnstone, Doug
name: Offner, Stella S. R.
name: Sadavoy, Sarah I.
name: Tobin, John J.
name: Arce, Hector G.
name: Bourke, Tyler L.
name: Mairs, Steve
name: Myers, Philip C.
name: Pineda, Jaime E.
name: Schnee, Scott
name: Shirley, Yancy L.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Compact substructure is expected to arise in a starless core as mass becomes concentrated in the central region likely to form a protostar. Additionally, multiple peaks may form if fragmentation occurs. We present ALMA Cycle 2 observations of 60 starless and protostellar cores in the Ophiuchus molecular cloud. We detect eight compact substructures which are >15 arcsec from the nearest Spitzer YSO. Only one of these has strong evidence for being truly starless after considering ancillary data, e.g., from Herschel and X-ray telescopes. An additional extended emission structure has tentative evidence for starlessness. The number of our detections is consistent with estimates from a combination of synthetic observations of numerical simulations and analytical arguments. This result suggests that a similar ALMA study in the Chamaeleon I cloud, which detected no compact substructure in starless cores, may be due to the peculiar evolutionary state of cores in that cloud.
description: accepted for publication in ApJ. 34 pages
Additional file 1: of MicroRNA-135a regulates NHE9 to inhibit proliferation and migration of glioblastoma cells
Creators: name: Zubieta, Daniela Gomez
name: Hamood, Mohamed
name: Beydoun, Rami
name: Pall, Ashley
name: Kondapalli, Kalyan
Publisher: name: figshare
Year: 2017
Subjects: subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Supplementary Material. (DOCX 1304 kb)
Synergy effects of copper ion in doxorubicin-based chelate prodrug for cancer chemo-chemodynamic combination therapy
Creators: name: Zhang, Wen
name: Zhang, Peng
name: Xu, Xiaopeng
name: Li, Minghui
name: Wang, Shasha
name: Mu, Hongjie
name: Sun, Kaoxiang
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biochemistry
Space Science
Pharmacology
Chemical Sciences not elsewhere classified
Cancer

description: Doxorubicin (DOX) is a commonly studied chemotherapeutic agent for the treatment of solid tumors, but the severe side effects limit its clinical application. It is shown that DOX-metal chelate has lower in vitro cytotoxicity compared with DOX, as the anthracyclines of DOX can form coordinative interaction with transition metal ions. In addition, the transition metal ions could catalyze the production of hydroxyl radicals (·OH) via Fenton/Fenton-like reactions to achieve antitumor chemodynamic therapy (CDT). In this study, copper ions (Cu2+) were applied to obtain DOX/Cu(II) prodrug, and a liposomal formulation was used to avoid the rapid blood clearance and optimize the biodistribution of this prodrug. In vitro and in vivo antitumor results demonstrated that this pH sensitive Cu-chelating prodrug can reduce adverse effects of DOX but improve the antitumor efficiency due to the combination of chemotherapy and chemodynamic therapy. Our study provided a facile and effective approach of metal-chelating prodrug strategy for combination cancer therapy strategy.
Novel self-similar rotating solutions of non-ideal transverse magnetohydrodynamics
Creators: name: Shokri, M.
name: Sadooghi, N.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Nuclear Theory (nucl-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: The evolution of electromagnetic and thermodynamic fields in a non-ideal fluid are studied in the framework of ultrarelativistic transverse magnetohydrodynamics (MHD), which is essentially characterized by electric and magnetic fields being transverse to the fluid velocity. Extending the method of self-similar solutions of relativistic hydrodynamics to the case of non-conserved charges, the differential equations of non-ideal transverse MHD are solved, and two novel sets of self-similar solutions are derived. The first set turns out to be a boost-invariant and exact solution, which is characterized by non-rotating electric and magnetic fields. The second set is a non-boost-invariant solution, which is characterized by rotating electric and magnetic fields. The rotation occurs with increasing rapidity $η$, as the angular velocity is defined by $ω_{0}\equiv\frac{\partialζ}{\partialη}=\frac{\partialϕ}{\partialη}$, with $ζ$ and $ϕ$ being the angles of electric and magnetic vectors with respect to a certain axis in the local rest frame of the fluid. For both sets of solutions, the electric and magnetic fields are either parallel or anti-parallel to each other. Performing a complete numerical analysis, the effects of finite electric conductivity as well as electric and magnetic susceptibilities of the medium on the evolution of rotating and non-rotating MHD solutions are explored, and the interplay between the angular velocity $ω_{0}$ and these quantities is scrutinized. The lifetime of electromagnetic fields and the evolution of the temperature of the electromagnetized fluid are shown to be affected by $ω_{0}$.
description: 33 pages, 18 figures
SINFONI-HiZELS: The dynamics, merger rates & metallicity gradients of `typical' star-forming galaxies at $z$ = 0.8-2.2
Creators: name: Molina, J.
name: Ibar, E.
name: Swinbank, A. M.
name: Sobral, D.
name: Best, P. N.
name: Smail, I.
name: Escala, A.
name: Cirasuolo, M.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present adaptive optics (AO) assisted SINFONI integral field unit (IFU) spectroscopy of eleven H$α$ emitting galaxies selected from the High-Z Emission Line Survey (HiZELS). We obtain spatially resolved dynamics on ~kpc-scales of star-forming galaxies (stellar mass M$_\star$ = 10$^{9.5-10.5}$ M$_\odot$ and star formation rate SFR = 2-30 M$_\odot$ yr$^{-1}$) near the peak of the cosmic star-formation rate history. Combining these observations with our previous SINFONI-HiZELS campaign, we construct a sample of twenty homogeneously selected galaxies with IFU AO-aided observations -- the `SHiZELS' survey, with roughly equal number of galaxies per redshift slice, at $z$ = 0.8, 1.47, and 2.23. We measure the dynamics and identify the major kinematic axis by modelling their velocity fields to extract rotational curves and infer their inclination-corrected rotational velocities. We explore the stellar mass Tully-Fisher relationship, finding that galaxies with higher velocity dispersions tend to deviate from this relation. Using kinemetry analyses we find that galaxy interactions might be the dominant mechanism controlling the star-formation activity at $z$ = 2.23 but they become gradually less important down to $z$ = 0.8. Metallicity gradients derived from the [NII]/H$α$ emission line ratio show a median negative gradient for the SHiZELS survey of $Δ$log(O/H)/$Δ$R = -0.026$\pm$0.008 dex kpc$^{-1}$. We find that metal-rich galaxies tend to show negative gradients, whereas metal-poor galaxies tend to exhibit positive metallicity gradients. This result suggests that the accretion of pristine gas in the periphery of galaxies plays an important role in replenishing the gas in `typical' star-forming galaxies.
description: Accepted for publication in MNRAS. 16 pages, 10 figures, 2 tables
Development of an apolipoprotein E mimetic peptide–lipid conjugate for efficient brain delivery of liposomes
Creators: name: Kato, Naoya
name: Yamada, Sakura
name: Suzuki, Rino
name: Iida, Yoshiki
name: Matsumoto, Makoto
name: Fumoto, Shintaro
name: Arima, Hidetoshi
name: Mukai, Hidefumi
name: Kawakami, Shigeru
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Biochemistry
Space Science
Medicine
Cell Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: Liposomes are versatile carriers that can encapsulate various drugs; however, for delivery to the brain, they must be modified with a targeting ligand or other modifications to provide blood–brain barrier (BBB) permeability, while avoiding rapid clearance by reticuloendothelial systems through polyethylene glycol (PEG) modification. BBB-penetrating peptides act as brain-targeting ligands. In this study, to achieve efficient brain delivery of liposomes, we screened the functionality of eight BBB-penetrating peptides reported previously, based on high-throughput quantitative evaluation methods with in vitro BBB permeability evaluation system using Transwell, in situ brain perfusion system, and others. For apolipoprotein E mimetic tandem dimer peptide (ApoEdp), which showed the best brain-targeting and BBB permeability in the comparative evaluation of eight peptides, its lipid conjugate with serine–glycine (SG)5 spacer (ApoEdp-SG-lipid) was newly synthesized and ApoEdp-modified PEGylated liposomes were prepared. ApoEdp-modified PEGylated liposomes were effectively associated with human brain capillary endothelial cells via the ApoEdp sequence and permeated the membrane in an in vitro BBB model. Moreover, ApoEdp-modified PEGylated liposomes accumulated in the brain 3.9-fold higher than PEGylated liposomes in mice. In addition, the ability of ApoEdp-modified PEGylated liposomes to localize beyond the BBB into the brain parenchyma in mice was demonstrated via three-dimensional imaging with tissue clearing. These results suggest that ApoEdp-SG-lipid modification is an effective approach for endowing PEGylated liposomes with the brain-targeting ability and BBB permeability.
title: Biochemical Profiling of Gout Patients
Creators: name: Schlitt, Tamera Fayre
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 2006

description: The purpose of the research is to investigate the biochemical cause of gout in 82 patients. The gouty patients had been diagnosed with gout according to the criterion of the American Rheumatism Association. This gout patient population consisted of 58 men and 24 women with gout whose ages ranged from 11 to 84 years of age with a mean age of 44 years. Key purine metabolism enzyme activity levels and purine metabolite concentrations in the patients' plasma and urine were compared to the mean values of a healthy control group. The control group consisted of 33 males and 25 female who did not have primary or secondary hyperuricemia expressed for the past two generations, and did not have any immediate family members suffering from gouty diseases. Their ages ranged from 8 to 75 years with a mean age of 36. Based on the results of the purine metabolism enzyme activity levels, the patients are classified as one of eight groups.

The plasma urate was determined by the uricase-peroxidase coupling reaction. Plasma hypoxanthine and xanthine concentrations were determined by HPLC. Erythrocyte red blood cell phosphoribosylpyrophosphate (PRPP) synthetase, hypoxanthine-guanine phosphoribosyltransferase (HPRT), and adenine phosphoribosyltransferase (APRT) activities were determined by using a combination of enzymatic and high performance liquid chromatography (HPLC) methods.

The study found that the mean levels of xanthine, uric acid, hypoxanthine, and erythrocyte PRPP synthetase levels for gouty patients were significantly higher than normal healthy controls. While no differences in biochemical parameters were found between male and female gout patients, there was a significant difference between the male and female control patient's biochemical parameters. The gout patients were further classified based on their biochemical profile of enzyme function abnormalities, with 13% of the population found to have multiple abnormalities. These patients were in the first seven biochemical profiles. 48.9% of the remaining patients were classified as Group 8, which is classified with other possible factors, such as renal clearance issues. The involvement of renal clearance of urate should be further investigated.
Conceptual Spaces for Cognitive Architectures: A Lingua Franca for Different Levels of Representation
Creators: name: Lieto, Antonio
name: Chella, Antonio
name: Frixione, Marcello
Publisher: name: arXiv
Year: 2017
Subjects: subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: During the last decades, many cognitive architectures (CAs) have been realized adopting different assumptions about the organization and the representation of their knowledge level. Some of them (e.g. SOAR [Laird (2012)]) adopt a classical symbolic approach, some (e.g. LEABRA [O'Reilly and Munakata (2000)]) are based on a purely connectionist model, while others (e.g. CLARION [Sun (2006)] adopt a hybrid approach combining connectionist and symbolic representational levels. Additionally, some attempts (e.g. biSOAR) trying to extend the representational capacities of CAs by integrating diagrammatical representations and reasoning are also available [Kurup and Chandrasekaran (2007)]. In this paper we propose a reflection on the role that Conceptual Spaces, a framework developed by Peter Gärdenfors [Gärdenfors (2000)] more than fifteen years ago, can play in the current development of the Knowledge Level in Cognitive Systems and Architectures. In particular, we claim that Conceptual Spaces offer a lingua franca that allows to unify and generalize many aspects of the symbolic, sub-symbolic and diagrammatic approaches (by overcoming some of their typical problems) and to integrate them on a common ground. In doing so we extend and detail some of the arguments explored by Gärdenfors [Gärdenfors (1997)] for defending the need of a conceptual, intermediate, representation level between the symbolic and the sub-symbolic one.
description: 31 pages, 3 figures in Biologically Inspired Cognitive Architectures, 2017
ATENCION INTEGRAL A NIÑAS Y ADOLESCENTES EMBARAZADAS MENORES DE 15 AÑOS
Creators: name: JACOME ARTIEDA, PATRICIO
Publisher: name: Zenodo
Year: 2024

description: En el 2021 se registraron un total de 1.843 nacidos vivos hijos fe adolescentes de entre ds10 a 14 años lo que correspondió a una tasa de 2.2 nacidos vivos por c/1000 adolescentes.  Dentro de ese rango de edad.  En promedio se ha visto que cada día 5 adolescentes dentro de esas edades ya son madres.

Ante esta situación el MSP elaboró y publico el manual normativo sobre Atención Integral a niñas y adolescentes embarazadas menores de 15 años., basándonos en esa norma, vemos que este tipo de atención debe orientarse en el reconocimiento de los derechos sexuales y reproductivos de las adolescentes menores de 15 años ya que de acuerdo con la ley ecuatoriana al encontrarse embarazadas, son consideran víctimas de violación. 
description: Ponencia del Primer Simposio de Derechos Sexuales y Reproductivos enfocado en dignificar a niñas, mujeres y personas con capacidad de gestar en caso de violación.
Additional file 2: of Process-oriented evaluation of an international faculty development program for Asian developing countries: a qualitative study
Creators: name: Do-Hwan Kim
name: Jong-Hyuk Lee
name: Park, Jean
name: Jwa-Seop Shin
Publisher: name: figshare
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: Process-oriented evaluation 03. Quantitative evaluation of level 1 (reaction) and level 2 (learning) of the Kirkpatrick model. Comparison of the evaluation results between two programs, which shows the LJWF-HPE demonstrated comparable outcomes to the SICME. (DOCX 22 kb)
ATENCION INTEGFRAL A NIÑAS Y ADOLESCENTES EMBARAZADAS MENORES DE 15 AÑOS
Creators: name: JACOME ARTIEDA, PATRICIO
Publisher: name: Zenodo
Year: 2024

description: En el 2021 se registraron un total de 1.843 nacidos vivos hijos fe adolescentes de entre ds10 a 14 años lo que correspondió a una tasa de 2.2 nacidos vivos por c/1000 adolescentes.  Dentro de ese rango de edad.  En promedio se ha visto que cada día 5 adolescentes dentro de esas edades ya son madres.

Ante esta situación el MSP elaboró y publico el manual normativo sobre Atención Integral a niñas y adolescentes embarazadas menores de 15 años., basándonos en esa norma, vemos que este tipo de atención debe orientarse en el reconocimiento de los derechos sexuales y reproductivos de las adolescentes menores de 15 años ya que de acuerdo con la ley ecuatoriana al encontrarse embarazadas, son consideran víctimas de violación. 
description: Ponencia del Primer Simposio de Derechos Sexuales y Reproductivos enfocado en dignificar a niñas, mujeres y personas con capacidad de gestar en caso de violación.
A Non-Intrusive Load Monitoring Framework for Robust Real-Time Disaggregation of Smart Meter Data
Creators: name: YUNG FEI WONG
Publisher: name: Monash University
Year: 2018
Subjects: subject: 170203 Knowledge Representation and Machine Learning
subject: FOS: Psychology
subject: Applied Computer Science
subject: 80109 Pattern Recognition and Data Mining
subject: FOS: Computer and information sciences
subject: 90699 Electrical and Electronic Engineering not elsewhere classified
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Reducing household electricity cost is traditionally a difficult task, as users have to use educated guesses to identify energy wastage caused by the inefficient use of appliances. This difficulty is largely a result of the poor feedback offered by traditional electricity bills, given that only the total energy consumption for a given billing cycle is shown, leaving users clueless about the actual cause of high energy consumption. While dedicated sensors can be installed to measure the energy consumption of each appliance in a house, the installation process is typically costly and intrusive. To that end, this thesis investigates and proposes mathematical techniques for Non-intrusive Load Monitoring, whereby measurements of total power consumption (from only a single sensor) are decomposed into their appliance contributions, enabling the relative proportion of energy of each appliance in the house to be obtained inexpensively.
Gas Accretion onto the Milky Way
Creators: name: Richter, Philipp
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The Milky Way is surrounded by large amounts of gaseous matter that are slowly being accreted over cosmic timescales to support star formation in the disk. The corresponding gas-accretion rate represents a key parameter for the past, present, and future evolution of the Milky Way. In this article, I discuss our current understanding of gas accretion processes in the Galaxy by reviewing past and recent observational and theoretical studies. The first part of this review deals with the spatial distribution of the different gas phases in the Milky Way halo, the origin of the gas, and its total mass. The second part discusses the gas dynamics and the physical processes that regulate the gas flow from the outer Galactic halo to the disk. From the most recent studies follows that the present-day gas accretion rate of the Milky Way is a few solar masses per year, which is sufficient to maintain the Galaxy's star-formation rate at its current level.
description: 33 pages, 7 figures; invited review to appear in Gas Accretion onto Galaxies, Astrophysics and Space Science Library, eds. A. J. Fox & R. Dave, to be published by Springer
Identifying a predictive relationship between maximal flow rate and viscosity for subcutaneous administration of macromolecules with recombinant human hyaluronidase PH20 in a miniature pig model
Creators: name: Connor, Robert J.
name: Clift, Renee
name: Kang, David W.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine

description: Subcutaneous (SC) infusion of large volumes at rapid flow rates has historically been limited by the glycosaminoglycan hyaluronan (HA), which forms a barrier to bulk fluid flow in the SC space. Recombinant human hyaluronidase PH20 (rHuPH20) depolymerizes HA, temporarily eliminating this barrier to rapid SC delivery of large volume co-administered therapeutics. Using a miniature pig model, in-line pressure and applied force to the delivery hardware were measured when subcutaneously infusing a representative macromolecule (human polyclonal immunoglobulin [Ig]), at varying concentrations and viscosities (20–200 mg/mL), co-formulated with and without rHuPH20 (2000 U/mL and 5000 U/mL). Maximal flow rate (Qmax) was calculated as the flow rate producing a statistically significant difference in mean applied force between injections administered with or without rHuPH20. There was a significant reduction in mean applied force required for SC delivery of 100 mg/mL Ig solution with 5000 U/mL rHuPH20 versus Ig solution alone. Similar significant reductions in mean applied force were observed for most Ig solution concentrations, ranging from 25–200 mg/mL when administered with or without 2000 U/mL rHuPH20. Qmax was inversely proportional to Ig solution viscosity and Qmax for solutions co-formulated with 5000 U/mL rHuPH20 was approximately double that of 2000 U/mL rHuPH20 solutions. Mathematical simulation of a hypothetical 800 mg Ig dose co-formulated with rHuPH20 showed that delivery times <30 s could be achieved across a broad range of concentrations. Addition of rHuPH20 can help overcome volume and time constraints associated with SC administration across a range of concentrations in a dose-dependent manner.
Additional file 1: of Process-oriented evaluation of an international faculty development program for Asian developing countries: a qualitative study
Creators: name: Do-Hwan Kim
name: Jong-Hyuk Lee
name: Park, Jean
name: Jwa-Seop Shin
Publisher: name: figshare
Year: 2017
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy
subject: Computational Biology

description: Process-oriented evaluation 03. Interview agendas for participants. A guide for semi-structured interviews for LJWF-HPE. (DOCX 20 kb)
Penerapan Data Mining dengan Algoritma C4.5 dalam Pemesanan Obat Guna Meningkatkan Keuntungan Apotek
Creators: name: Mahendra, Gede Surya
Publisher: name: figshare
Year: 2022
Subjects: subject: 80109 Pattern Recognition and Data Mining
subject: FOS: Computer and information sciences

description: Pharmacy is a very profitable business if managed properly. Pharmacy management must be able to manage drug orders and manage drug stocks effectively. Factors that need to be considered in ordering drugs are the number of items sold and data on patient drug requests that have not been fulfilled. The data sample used is sales data at pharmacies which are then grouped by type of drug class and analyzed using the C4.5 algorithm. The result of applying the C4.5 algorithm finds Category as the first root. The total number of existing categories is 27 units, then sorted by category of drug with the most, then only 10 categories are taken. Generic category drugs have the highest value for drugs that are sold well, While the Snack &Drink category has the highest value for drugs that are less sold. These results were then tested using a confusion matrix. The test results in 1949 True Positive, 102 False Negative, 527 False Positive, 2477 True Negative. The result accuracy rate is 87.56%, Precision 78.72%, Recall 95.03% and Error rate 12.44%. Future research can be compared using different methods. Keywords: Data Mining, C4.5 Algorithm, Drug Ordering
 Apotek merupakan usaha yang sangat menguntungkan jika dikelola dengan baik. Manajemen Apotek semestinya mampu mengatur pemesanan obat dan mengelola stok obat secara efektif. Faktor yang perlu dijadikan pertimbangan dalam pemesanan obat yaitu banyaknya jumlah barang yang terjual dan data permintaaan obat pasien yang selama belum bisa dipenuhi. Sampel data yang digunakan merupakan data penjualan di apotik yang kemudian dikelompokkan berdasarkan kelompok jenis obat dan dianalisa menggunakan algoritma C4.5. Hasil dari penerapan algoritma C4.5 ini menemukan Kategori sebagai akar yang pertama. Jumlah seluruh kategori yang ada berjumlah 27 buah, kemudian diurutkan berdasarkan kategori obat yang terbanyak, lalu diambil hanya 10 kategori. Kategori obat generic mempunyai nilai tertinggi untuk obat yang laku, sedangkan untuk kategori Sirup/drop dan kategori Snack & Drink memiliki nilai terginggi untuk yang kurang laku. Hasil ini kemudian diuji menggunakan confusion matrix. Pengujian mendapatkan hasil 1949 True Positive, 102 False Negative, 527 False Positive, 2477 True Negative. Tingkat akurasi hasil yaitu sebesar 87.56%, Presisi 78.72%, Recal 95.03% dan Error rate sebesar 12.44%. Penelitian kedepannya bisa dibandingkan dengan menggunakan metode yang berbeda.
title: ADCO, Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Cart. 32 (G 136), 745 folios, f. 0593
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 0593, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 0593, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Implementasi Pemilihan Maskapai Penerbangan Menggunakan FUCOM-MABAC Pada Sistem Pendukung Keputusan
Creators: name: Mahendra, Gede Surya
Publisher: name: figshare
Year: 2022
Subjects: subject: 80605 Decision Support and Group Support Systems
subject: FOS: Computer and information sciences
subject: 170202 Decision Making
subject: FOS: Psychology

description: Masih banyak maskapai yang menghadapi berbagai masalah, walaupun perkembangan industri jasa penerbangan Indonesia terus berkembang. Semakin baik standar kualitas pelayanan maskapai penerbangan yang dipilih, maka semakin besar minat calon penumpang untuk menggunakan layanannya. Banyaknya pilihan dan pertimbangan untuk memilih maskapai sering membingungkan pelanggan, karena setiap maskapai memiliki kekuatannya sendiri. Untuk mengatasi masalah ini, sistem pendukung keputusan (SPK) dapat digunakan dalam pemilihan maskapai berdasarkan preferensi pelanggan. Penelitian ini berhasil mengimplementasikan FUCOM-MABAC untuk menentukan maskapai penerbangan terpopuler di Indonesia. Kriteria harga (K4) ternyata menjadi concern utama bagi konsumen ketika perhitungan dengan FUCOM dilakukan. Perhitungan menggunakan FUCOM-MABAC menunjukkan bahwa Garuda Indonesia merupakan maskapai terpopuler di Indonesia dengan nilai preferensi 0,3188, disusul Citilink sebagai maskapai terpopuler kedua dan Batik Air sebagai ketiga. Pengujian menggunakan analisis konsistensi menunjukkan bahwa Garuda Indonesia menempati 11 besar dari 13 tes dengan distribusi peringkat rata-rata 1,29905, tetap stabil sebagai pilihan terbaik.
There are still many airlines that face various problems, although the development of the Indonesian aviation service industry continues to grow. The better the service quality standard of the selected airline, the greater the interest of prospective passengers to use its services. The many choices and considerations for choosing an airline often confuse customers, because each airline has its own strengths. To solve this problem, a decision support system (DSS) can be used in airline selection based on customer preferences. This study succeeded in implementing FUCOM-MABAC to determine the most popular airlines in Indonesia. The price criteria (K4) turned out to be the main concern of consumers when calculating with FUCOM. Calculations using FUCOM-MABAC show that Garuda Indonesia is the most popular airline in Indonesia with a preference value of 0.3188, followed by Citilink as the second most popular airline and Batik Air as the third. Tests using consistency analysis show that Garuda Indonesia occupies the top 11 out of 13 tests with an average rating distribution of 1.29905, remaining stable as the best choice.
Formulation and characterization of lamotrigine nasal insert targeted brain for enhanced epilepsy treatment
Creators: name: Abdelmonem, Rehab
name: El-Enin, Hadel A. Abo
name: Abdelkader, Ghada
name: Abdel-Hakeem, Mohamed
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Lamotrigine. (LMT) is a triazine drug has an antiepileptic effect but with low water solubility, dissolution rate and thus therapeutic effect. Spanlastics are nano-vesicular carriers’ act as site-specific drug delivery system. Intranasal route could direct the drug from nose to brain and provide a faster and more specific therapeutic effect. Therefore, this study aimed to upload lamotrigine onto nano-vesicles using spanlastic nasal insert delivery for effective epilepsy treatment via overcoming lamotrigine’s low solubility and improving its bioavailability. Lamtrigine-loaded nano-spanlastic vesicles were prepared by ethanol injection method. To study different formulation factor’s effect on formulations characters; particle size (PS), Zeta potential (ZP), polydispersity index (PDI), entrapment efficiency percentage (EE%) and LMT released amount after 6 h (Q6h); 2^1 and 3^1 full factorial designs were employed. Optimized formula was loaded in lyophilized nasal inserts formulation which were characterized for LMT release and mucoadhesion. Pharmacokinetics studies in plasma and brain were performed on rats to investigate drug targeting efficiency. The optimal nano-spanlastic formulation (F4; containing equal Span 60 amount (100 mg) and edge activator; Tween 80) exhibited nano PS (174.2 nm), high EE% (92.75%), and Q6h > 80%. The prepared nasal inserts (S4) containing 100 mg HPMC has a higher mucoadhesive force (9319.5 dyne/cm2) and dissolution rate (> 80% within 10 min) for rapid in vivo bio-distribution. In vivo studies showed considerable improvement brain and plasma’s rate and extent absorption after intranasal administration indicating a high brain targeting efficiency. The results achieved indicate that nano-spanlastic nasal-inserts offer a promising LMT brain targeting in order to maximize its antiepileptic effect.
Results from a set of three-dimensional numerical experiments of a hot Jupiter atmosphere
Creators: name: Mayne, N. J.
name: Debras, F.
name: Baraffe, I.
name: Thuburn, John
name: Amundsen, David S.
name: Acreman, David M.
name: Smith, Chris
name: Browning, Matthew K.
name: Manners, James
name: Wood, Nigel
Publisher: name: arXiv
Year: 2017
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We present highlights from a large set of simulations of a hot Jupiter atmosphere, nominally based on HD 209458b, aimed at exploring both the evolution of the deep atmosphere, and the acceleration of the zonal flow or jet. We find the occurrence of a super-rotating equatorial jet is robust to changes in various parameters, and over long timescales, even in the absence of strong inner or bottom boundary drag. This jet is diminished in one simulation only, where we strongly force the deep atmosphere equator-to-pole temperature gradient over long timescales. Finally, although the eddy momentum fluxes in our atmosphere show similarities with the proposed mechanism for accelerating jets on tidally-locked planets, the picture appears more complex. We present tentative evidence for a jet driven by a combination of eddy momentum transport and mean flow.
description: 26 pages, 22 Figures. Accepted for publication in Astronomy and Astrophysics
title: Compas (Inv. 995.15.371.1) – Oppidum de Bibracte
Creators: name: Bibracte
Publisher: name: Conservatoire National des Données 3D (CND3D)
Year: 2024
Subjects: subject: compas

description: Avec ses deux branches mobiles dont l’écart variable est assuré par un rivet  ce compas nous semble presque contemporain. Connu dès l’Antiquité  il sert d’abord à comparer  reporter et mesurer des distances. Il est également le fruit des progrès réalisés dans la fabrication des instruments à tracer les cercles  qui ont été utilisés pour concevoir les savants décors curvilignes caractérisant l’art celtique à partir du 5e siècle avant notre ère.
Local Modular Hamiltonians from the Quantum Null Energy Condition
Creators: name: Koeller, Jason
name: Leichenauer, Stefan
name: Levine, Adam
name: Moghaddam, Arvin Shahbazi
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The vacuum modular Hamiltonian $K$ of the Rindler wedge in any relativistic quantum field theory is given by the boost generator. Here we investigate the modular Hamiltoninan for more general half-spaces which are bounded by an arbitrary smooth cut of a null plane. We derive a formula for the second derivative of the modular Hamiltonian with respect to the coordinates of the cut which schematically reads $K" = T_{vv}$. This formula can be integrated twice to obtain a simple expression for the modular Hamiltonian. The result naturally generalizes the standard expression for the Rindler modular Hamiltonian to this larger class of regions. Our primary assumptions are the quantum null energy condition --- an inequality between the second derivative of the von Neumann entropy of a region and the stress tensor --- and its saturation in the vacuum for these regions. We discuss the validity of these assumptions in free theories and holographic theories to all orders in $1/N$.
description: 6 pages, 1 figure
Additional file 10: of Over-expressed lncRNA HOTAIRM1 promotes tumor growth and invasion through up-regulating HOXA1 and sequestering G9a/EZH2/Dnmts away from the HOXA1 gene in glioblastoma multiforme
Creators: name: Li, Qi
name: Dong, Chengya
name: Cui, Jiayue
name: Wang, Yubo
name: Hong, Xinyu
Publisher: name: figshare
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Figure S4. Knockdown of HOTAIRM1 inhibits migration and invasion of established and primary GBM cells. (DOCX 203 kb)
Evaluation of commercial nickel-phosphorus coating for ultracold neutron guides using a pinhole bottling method
Creators: name: Pattie, R. W.
name: Adamek, E.
name: Brenner, T.
name: Brandt, A.
name: Broussard, L. J.
name: Callahan, N. B.
name: Clayton, S. M.
name: Cude-Woods, C.
name: Currie, S. A.
name: Geltonbort, P.
name: Ito, T.
name: Lauer, T.
name: Liu, C. Y.
name: Majewski, J.
name: Makela, M.
name: Masuda, Y.
name: Morris, C. L.
name: Ramsey, J. C.
name: Salvat, D.
name: Saunders, A.
name: Schroffenegger, J.
name: Tang, Z.
name: Wei, W.
name: Wang, Z.
name: Watkins, E.
name: Young, A. R.
name: Zeck, B. A.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We report on the evaluation of commercial electroless nickel phosphorus (NiP) coatings for ultracold neutron (UCN) transport and storage. The material potential of 50~$μ$m thick NiP coatings on stainless steel and aluminum substrates was measured to be $V_F = 213(5.2)$~neV using the time-of-flight spectrometer ASTERIX at the Lujan Center. The loss per bounce probability was measured in pinhole bottling experiments carried out at ultracold neutron sources at Los Alamos Neutron Science Center and the Institut Laue-Langevin. For these tests a new guide coupling design was used to minimize gaps between the guide sections. The observed UCN loss in the bottle was interpreted in terms of an energy independent effective loss per bounce, which is the appropriate model when gaps in the system and upscattering are the dominate loss mechanisms, yielding a loss per bounce of $1.3(1) \times 10^{-4}$. We also present a detailed discussion of the pinhole bottling methodology and an energy dependent analysis of the experimental results.
description: 13 pages, 14 figures
A quality by design approach for the synthesis of palmitoyl-L-carnitine-loaded nanoemulsions as drug delivery systems
Creators: name: Arroyo-Urea, E. M.
name: Muñoz-Hernando, María
name: Leo-Barriga, Marta
name: Herranz, Fernando
name: González-Paredes, Ana
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology

description: Nanoemulsions (NE) are lipid nanocarriers that can efficiently load hydrophobic active compounds, like palmitoyl-L-carnitine (pC), used here as model molecule. The use of design of experiments (DoE) approach is a useful tool to develop NEs with optimized properties, requiring less experiments compared to trial-and-error approach. In this work, NE were prepared by the solvent injection technique and DoE using a two-level fractional factorial design (FFD) as model was implemented for designing pC-loaded NE. NEs were fully characterized by a combination of techniques, studying its stability, scalability, pC entrapment and loading capacity and biodistribution, which was studied ex-vivo after injection of fluorescent NEs in mice. We selected the optimal composition for NE, named pC-NEU, after analysis of four variables using DoE. pC-NEU incorporated pC in a very efficient manner, with high entrapment efficiency (EE) and loading capacity. pC-NEU did not change its initial colloidal properties stored at 4 °C in water during 120 days, nor in buffers with different pH values (5.3 and 7.4) during 30 days. Moreover, the scalability process did not affect NE properties and stability profile. Finally, biodistribution study showed that pC-NEU formulation was predominantly concentrated in the liver, with minimal accumulation in spleen, stomach, and kidneys.
Gas Accretion in Star-Forming Galaxies
Creators: name: Kacprzak, Glenn G.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Cold-mode gas accretion onto galaxies is a direct prediction of LCDM simulations and provides galaxies with fuel that allows them to continue to form stars over the lifetime of the Universe. Given its dramatic influence on a galaxy's gas reservoir, gas accretion has to be largely responsible for how galaxies form and evolve. Therefore, given the importance of gas accretion, it is necessary to observe and quantify how these gas flows affect galaxy evolution. However, observational data have yet to conclusively show that gas accretion ubiquitously occurs at any epoch. Directly detecting gas accretion is a challenging endeavor and we now have obtained a significant amount of observational evidence to support it. This chapter reviews the current observational evidence of gas accretion onto star-forming galaxies.
description: Invited review to appear in Gas Accretion onto Galaxies, Astrophysics and Space Science Library, eds. A. J. Fox & R. Dav\'e, to be published by Springer. This chapter includes 22 pages with 7 Figures