MOESM2 of Sex differences in brain structure: a twin study on restricted and repetitive behaviors in twin pairs with and without autism
Creators: name: Westeinde, Annelies
name: Élodie Cauvet
name: Toro, Roberto
name: Kuja-Halkola, Ralf
name: Neufeld, Janina
name: Mevel, Katell
name: Bölte, Sven
Publisher: name: figshare
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: FOS: Chemical sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: FOS: Health sciences
subject: Hematology

description: Additional file 2: Table S7A. Within-pair associations between cortical volume, surface area and thickness of neocortical regions of interest (ROIs) and RRB symptoms from SRS-2. Estimates (B), standard deviations (SD) and q-values (q) for the within pair associations between all surface-based neocortical measures (volume, surface area and thickness) and RRBs as assessed by the SRS-2. A positive estimate indicates an increase in brain estimate related to more repetitive behavior symptoms. Bold text indicates significant associations (FDR-corrected q-value &lt;0.05) or associations with q-value &lt; 0.10 (FDR-corrected). Table S7B. Within-pair associations between cortical volume of subcortical and cerebellar regions of interest (ROIs) and RRB symptoms from SRS-2. Estimates (B), standard deviations (SD) and q-values (q) for the within pair associations between subcortical &amp; cerebellar volumes and RRBs as assessed by the SRS-2. A positive estimate indicates an increase in brain estimate related to more repetitive behavior symptoms. Bold text indicates significant associations (FDR-corrected q-value &lt;0.05) or associations with q-value &lt; 0.10 (FDR-corrected). All results are FDR corrected. L. = Left, R. = Right. Table S8A. Within-pair model for RRBI’s (from ADI-R) predicting atomy of neocortical ROI’s, while controlling for social interaction deficits (from ADI-R). Estimates (B), standard deviations (SD) and q-values (q) for the linear associations between all surface-based neocortical measures (volume, surface area and thickness) and RRBs as assessed by the ADI-R, while controlling for autistic symptoms from the social domain, as assessed by the ADI-R. A positive estimate indicates an increase in brain estimate related to more repetitive behavior symptoms. Bold text indicates significant associations (FDR-corrected q-value &lt;0.05) or associations with q-value &lt; 0.10 (FDR-corrected). All results are FDR corrected. Table S8B. Within pair model for RRBI’s (from ADI-R) predicting atomy of subcortical and cerebellar ROI’s, while controlling for social interaction deficits (from ADI-R). Estimates (B), standard deviations (SD) and q-values (q) for the within-pair associations between subcortical measures (volumes only) and RRBs as assessed by the ADI-R, while controlling for autistic symptoms from the social domain, as assessed by the ADI-R. A positive estimate indicates an increase in brain estimate related to more repetitive behavior symptoms. Bold text indicates significant associations (FDR-corrected q-value &lt;0.05) or associations with q-value &lt; 0.10 (FDR-corrected). All results are FDR corrected. L. = Left, R. = Right. Table S9A. Within-pair model for RRBI’s (from SRS) predicting atomy of neocortical ROI’s, while controlling for social cognition deficits (from SRS). Estimates (B), standard deviations (SD) and q-values (q) for the within pair associations between all surface-based neocortical measures (volume, surface area and thickness) and RRBs as assessed by the SRS, while controlling for autistic symptoms from the social domain, as assessed by the SRS. A positive estimate indicates an increase in brain estimate related to more repetitive behavior symptoms. Bold text indicates significant associations (FDR-corrected q-value &lt;0.05) or associations with q-value &lt; 0.10 (FDR-corrected). All results are FDR corrected. Table S9B. Within-pair model for RRBI’s (from SRS) predicting atomy of subcortical and cerebellar ROI’s, while controlling for social cognition deficits (from SRS). Estimates (B), standard deviations (SD) and q-values (q) for the within pair associations between subcortical measures (volumes only) and RRBs as assessed by the SRS, while controlling for autistic symptoms from the social domain, as assessed by the SRS. A positive estimate indicates an increase in brain estimate related to more repetitive behavior symptoms. Bold text indicates significant associations (FDR-corrected q-value &lt;0.05) or associations with q-value &lt; 0.10 (FDR-corrected). All results are FDR corrected. L. = Left, R. = Right. Table S10A. Linear model assessing the interaction between age and RRBI symptoms (ADI-R) and neocortical regions of interest. Estimates (B), standard deviations (SD) and q-values (q) for the linear interaction associations between age (years) and RRBIs as assessed by the ADI-R on neocortical volume, surface area and thickness. Bold text indicates significant associations (FDR-corrected q-value &lt;0.05) or associations with q-value &lt; 0.10 (FDR-corrected). All results are FDR corrected. Table S10B. Linear model assessing the interaction between age and RRBI symptoms (ADI-R) and subcortical regions of interest. Estimates (B), standard deviations (SD) and q-values (q) for the linear interaction associations between age (years) and RRBIs as assessed by the ADI-R on subcortical volumes. Bold text indicates significant associations (FDR-corrected q-value &lt;0.05) or associations with q-value &lt; 0.10 (FDR-corrected). All results are FDR corrected. L. = Left, R. = Right.