cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A photonic engine fueled by quantum-correlated atoms
Creators: name: Feyisa, Chimdessa Gashu
name: Jen, H. H.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Entangled states are an important resource for quantum information processing and for the fundamental understanding of quantum physics. An intriguing open question would be whether entanglement can improve the performance of quantum heat engines in particular. One of the promising platforms to address this question is to use entangled atoms as a non-thermal bath for cavity photons, where the cavity mirror serves as a piston of the engine. Here we theoretically investigate a photonic quantum engine operating under an effective reservoir consisting of quantum-correlated pairs of atoms. We find that maximally entangled Bell states alone do not help extract useful work from the reservoir unless some extra populations in the excited states or ground states are taken into account. Furthermore, high efficiency and work output are shown for the non-maximally entangled superradiant state, while negligible for the subradiant state due to lack of emitted photons inside the cavity. Our results provide insights in the role of quantum-correlated atoms in a photonic engine and present new opportunities in designing a better quantum heat engine.
description: 7 figures
Comparison of antioxidant, anticholinesterase, and antidiabetic activities of three curcuminoids isolated from Curcuma longa L.
Creators: name: Kalaycıoğlu, Zeynep
name: Işıl Gazioğlu
name: F. Bedia Erim
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Antioxidant, anticholinesterase and antidiabetic activities of three curcuminoids isolated from the Curcuma longa were simultaneously tested and compared in this study. The highest antioxidant power was detected for curcumin with the applied methods. The drug potentials of curcuminoids for Alzheimer’s disease were controlled. Bisdemethoxycurcumin (BDMC) showed substantial inhibitory activity. The activity of demethoxycurcumin (DMC) followed BDMC, whereas curcumin showed very little acetylcholinesterase inhibition activity. Antidiabetic activity of curcuminoids was evaluated by their α-glucosidase inhibitory activities. All curcuminoids show activities with decreasing order as BDMC > curcumin > DMC. The significant activities of BDMC compared to its isomers and examination of chemical structures of isomers might be a starting point in designing new drugs for Alzheimer’s and Diabetes Mellitus.
Probing proton structure with $c \bar c$ correlations in ultraperipheral $pA$ collisions
Creators: name: Linek, Barbara
name: Łuszczak, Agnieszka
name: Łuszczak, Marta
name: Pasechnik, Roman
name: Schäfer, Wolfgang
name: Szczurek, Antoni
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the exclusive diffractive $c \bar c$ photoproduction in ultraperipheral $pA$ collisions. The formalism makes use of off-diagonal generalizations of the unintegrated gluon distribution, the so-called generalized transverse momentum dependent distributions (GTMDs). We present two different formulations. The first one is based directly on gluon GTMD parametrizations in momentum space. Another option is the calculation of the GTMD as a Fourier transform of the dipole-nucleon scattering amplitude $N(Y,\vec{r}_{\perp},\vec{b}_{\perp})$. The latter approach requires some extra regularization discussed in the paper. Different dipole amplitudes from the literature are used. Compared to previous calculations in the literature, we integrate over the full phase space and therefore cross sections for realistic conditions are obtained. We present distributions in rapidity of $c$ or $\bar c$, transverse momentum of the $c \bar c$ pair, four-momentum transfer squared as well as the azimuthal correlation between a sum and a difference of the $c$ and $\bar c$ transverse momenta. The azimuthal correlations are partially due to the so-called elliptic gluon Wigner distribution. Different models lead to different modulations in the azimuthal angle. The modulations are generally smaller than 5%. They depend on the range of transverse momentum selected for the calculation.
description: 22 pages, 14 figures, 1 table
Service Quality of Indian Insurance Sectors
Creators: name: C, Sankar
Publisher: name: figshare
Year: 2017
Subjects: subject: 150204 Insurance Studies
subject: FOS: Economics and business

description: Market research and finalizing on segmentation, targeting ahd positioning the strategy would focus on the marketing mix namely, Product, Price, Place and Promotion While determining the implementation methodology, the four characteristics viz. Intangibility. Inseparability, Perish ability and Variability gives rise, to certain unique requirements that deserve careful attention while formulating the marketing strategy for insurance. After implementation, the insurers should concentrate on the effective control that would enhance their business. In India Insurance is sold and not bought. The agents / Advisors by using various strategies sell the product by convincing the customers. Service sector is the lifeline for the social economic growth of a country It is today the largest and fastest growing sector globally contributing more to the global output and employing more people than any other sector. The real reason for the growth of the service sector is due to the increase in urbanization, privatization and more demand for intermediate and final consumer services. Availability of quality services is vital for the well being of the economy In developing economies, the insurance sector still holds a lot of potential which can be tapped Majority of the people in the developing countries remains unaware of the functions and benefits of insurance and it is for this reason that the insurance sector is still to grow. Tangible or intangible - an individual can insure anything! Be it a house, car, factory, or the voice of a singer, leg of a footballer, and the hand of an# author etc It is possible to insure all these as they have the possibility of becoming non functional by any disaster or an accident. On a product basis, investment-linked insurance products continued to perform worse than traditional products with guaranteed returns. Meanwhile, premiums in most emerging market countries, particularly in Asia, continued to grow, albeit at a slower pace. As major investors, life insurers profited from the recovery of stock and credit markets Profitability and risk capital also improved as capital markets rebounded, but have not yet returned to their pre-financial crisis levels.
First measurement of discrimination between helium and electron recoils in liquid xenon for low-mass dark matter searches
Creators: name: Haselschwardt, S. J.
name: Gibbons, R.
name: Chen, H.
name: Kravitz, S.
name: Manalaysay, A.
name: Xia, Q.
name: Sorensen, P.
name: Lippincott, W. H.
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We report the first measurement of discrimination between low-energy helium recoils and electron recoils in liquid xenon. This result is relevant to proposed low-mass dark matter searches which seek to dissolve light target nuclei in the active volume of liquid-xenon time projection chambers. Low-energy helium recoils were produced by degrading $α$ particles from $^{210}$Po with a gold foil situated on the cathode of a liquid xenon time-projection chamber. The resulting population of helium recoil events is well separated from electron recoils and is also offset from the expected position of xenon nuclear recoil events.
description: 4 pages, 3 figures
title: CFPR: interview avec FRA2019_0031
Creators: name: Delafontaine, François
name: Avanzi, Mathieu
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021
Subjects: subject: Français
subject: fra

description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.7d2b5lj5.v4#19b41232b4459fcccb3c35a6019b8bb92f1154b1
Guided quantum walk
Creators: name: Schulz, Sebastian
name: Willsch, Dennis
name: Michielsen, Kristel
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We utilize the theory of local amplitude transfers (LAT) to gain insights into quantum walks (QWs) and quantum annealing (QA) beyond the adiabatic theorem. By representing the eigenspace of the problem Hamiltonian as a hypercube graph, we demonstrate that probability amplitude traverses the search space through a series of local Rabi oscillations. We argue that the amplitude movement can be systematically guided towards the ground state using a time-dependent hopping rate based solely on the problem's energy spectrum. Building upon these insights, we extend the concept of multi-stage QW by introducing the guided quantum walk (GQW) as a bridge between QW-like and QA-like procedures. We assess the performance of the GQW on exact cover, traveling salesperson and garden optimization problems with 9 to 30 qubits. Our results provide evidence for the existence of optimal annealing schedules, beyond the requirement of adiabatic time evolutions. These schedules might be capable of solving large-scale combinatorial optimization problems within evolution times that scale linearly in the problem size.
Storage modulus’ variation in aging and its application in assessing the stability of emulsion explosive matrix
Creators: name: Zhang, Kai-Ming
name: Zhao, Hai-Rong
name: Ou-Qi Ni
name: Ren, Xiao-Ming
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: An investigation was performed into the stability of bulk emulsion explosive matrix (BEEM) via studying on the variation of storage modulus in aging. The experimental results show that there is a tight relationship between storage modulus (G′) and the stability of BEEM. The increase of the amount of ammonium nitrate (AN) crystals in aging leads to the increase of G′. When the amount of AN crystals reaches a certain extent, the vastly destroyed microstructure results in the disappear of viscoelastic property of BEEM. The results demonstrated that the less growth ratio of G′ causes a better stability of BEEM. The G′ was used to investigate the effect of the nature of emulsifier and continuous phase on the stability of BEEM. It is found that the chemical structure of head group, the length of hydrophobic chain and the content of emulsifier affect the stability of BEEM. Besides that, the viscosity and polarity of continuous phase also have important effect on the stability of BEEM.
Prevention of ferroptosis in acute scenarios: an in vitro study with classic and novel anti-ferroptotic compounds
Creators: name: Naime, Aline Aita
name: Barbosa, Flavio Augusto Rocha
name: Bueno, Diones Caeran
name: Pedrosa, Rozangela Curi
name: Canto, Rômulo Faria Santos
name: Colle, Dirleise
name: Braga, Antônio Luiz
name: Farina, Marcelo
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Ferroptosis, an iron-dependent form of cell death, has critical roles in diverse pathologies. Data on the temporal events mediating the prevention of ferroptosis are lacking. Focused on temporal aspects of cytotoxicity/protection, we investigated the effects of classic (Fer-1) and novel [2,6-di-tert-butyl-4-(2-thienylthio)phenol (C1) and 2,6-di-tert-butyl-4-(2-thienylselano)phenol (C2)] anti-ferroptotic agents against RSL3-, BSO- or glutamate-induced ferroptosis in cultured HT22 neuronal cell line, comparing their effects with those of the antioxidants trolox, ebselen and probucol. Glutamate (5 mM), BSO (25 μM) and RSL3 (50 nM) decreased approximately 40% of cell viability at 24 h. At these concentrations, none of these agents changed cell viability at 6 h after treatments; RSL3 increased lipoperoxidation from 6 h, although BSO and glutamate only did so at 12 h after treatments. At similar conditions, BSO and glutamate (but not RSL3) decreased GSH levels at 6 h after treatments. Fer-1, C1 and C2 exhibited similar protective effects against glutamate-, BSO- and RSL3-cytotoxicity, but this protection was limited when the protective agents were delivered to cells at time-points characterized by increased lipoperoxidation (but not glutathione depletion). Compared to Fer-1, C1 and C2, the anti-ferroptotic effects of trolox, ebselen and probucol were minor. Cytoprotective effects were not associated with direct antioxidant efficacies. These results indicate that the temporal window is central in affecting the efficacies of anti-ferroptotic drugs in acute scenarios; ferroptosis prevention is improbable when significant rates of lipoperoxidation were already achieved. C1 and C2 displayed remarkable cytoprotective effects, representing a promising new class of compounds to treat ferroptosis-related pathologies.
Synthetic route for the novel pyrimidine-substituted alkanoate, acetohydrazide, and imines: Synthon for β-lactams
Creators: name: Preety Saini
name: Bari, Shamsher S.
name: Bimal K. Banik
name: Bhalla, Aman
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Plant Biology

description: A simple and efficient synthesis of novel pyrimidine-substituted alkanoate, acetohydrazide, and imines is described. The synthesis of novel ethyl 2-(2,6-dimethylpyrimidin-4-yloxy)acetate (EDMPyA) 2 was performed through SN2 O-alkylation of 2,6-dimethyl-4-hydroxypyrimidine 1 with ethyl haloacetate. The compound EDMPyA 2 was subjected to nucleophilic substitution reaction with hydrazine hydrate to afford novel 2-(2,6-dimethylpyrimidin-4-yloxy)acetohydrazide (DMPyAH) 3. This DMPyAH 3 upon condensation with differently substituted carbonyl compounds (aldehydes/ketones) furnished DMPyAH imines (DMPyAH-I) 4a–d. These imines can be used for the preparation of unique β-lactams. The structure elucidation of all the newly synthesized compounds was performed using spectroscopy (FT-IR, 1H and 13C NMR) and elemental analysis (C, H, N).
MicroRNA-1287-5p promotes ferroptosis of osteosarcoma cells through inhibiting GPX4
Creators: name: Xu, Zhengquan
name: Chen, Lanhua
name: Wang, Changsheng
name: Zhang, Liqun
name: Xu, Weihong
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Cancer
subject: Hematology

description: Osteosarcoma is the most prevalent primary bone malignancy in adolescents, and ferroptosis is implicated in its pathogenesis. MicroRNA (miR)-1287-5p plays critical roles in multiple human cancers, and the present study aims to investigate the role and underlying mechanisms of miR-1287-5p in regulating ferroptosis and osteosarcoma progression. Human osteosarcoma cell lines were treated with the mimic, inhibitor or matched controls of miR-1287-5p. Cell viability, colony formation, cell death ratio and ferroptosis were determined. miR-1287-5p expression was downregulated in human osteosarcoma, but upregulated upon ferroptotic stimulation. Overexpression of miR-1287-5p significantly induced, while inhibition of miR-1287-5p suppressed ferroptosis of osteosarcoma cells, thereby modulating cell viability and colony formation. Mechanistic studies indicated that miR-1287-5p directly bound to the 3′-untranslated region of glutathione peroxidase 4 (GPX4) to inhibit its protein level and activity, and that GPX4 overexpression completely abolished the miR-1287-5p mimic-mediated ferroptotic induction and tumor suppression. Moreover, the miR-1287-5p mimic dramatically sensitized human osteosarcoma cells to cisplatin chemotherapy. Our findings prove that miR-1287-5p promotes ferroptosis of osteosarcoma cells through inhibiting GPX4, identifying an adjuvant and even alternative method for the treatment of human osteosarcoma.
Supplementary material for: Gene Expression Changes in Spleens and Livers of Tumour-Bearing Mice Suggest Delayed Inflammation and Attenuated Cachexia in Response to Oil Palm Phenolics
Creators: name: Leow, S.-S.
name: Sekaran, S.D.
name: Sundram, K.
name: Tan, Y.
name: Sambanthamurthi, R.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Background/Aim: Plant phenolics can inhibit, retard or reverse carcinogenesis, and may thus help prevent or treat cancer. Oil palm phenolics (OPP) previously showed anti-tumour activities in vivo via a cytostatic mechanism at 1,500 ppm gallic acid equivalent. Here, we report other possible molecular mechanisms by which this extract attenuates cancer, especially those concerning the immune response. Methods: We subcutaneously injected J558 myeloma cells in BALB/c mice and supplemented OPP orally at 1,500 ppm gallic acid equivalent. We observed the physiology parameters of these animals and harvested their spleens and livers after 18 h, 1 week and 4 weeks for microarray gene expression analysis using Illumina MouseRef-8 BeadChips. Results: Time course microarray analysis on spleens after injecting J558 myeloma cells in mice revealed that the immune response of tumour-bearing mice supplemented with OPP was lower compared to controls, thus suggesting delayed inflammation in response to OPP. In livers, cholesterol biosynthesis genes were upregulated while inflammatory genes were downregulated through time, further suggesting attenuation of systemic inflammation and cachexia. These effects correlated with the delayed in vivo development of syngeneic tumours in mice given OPP. Conclusions: This study suggests the possible utilisation of OPP as an anti-tumour and anti-cachexia agent.
Optimization of A-TIG Process Parameters Using Response Surface Methodology
Creators: name: Vidyarthy, Ravi Shanker
name: Dheerendra Kumar Dwivedi
name: Vasudevan Muthukumaran
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Space Science
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: In the present work, the influence of process parameters such as welding current (I), welding speed (S), and flux coating density (F) on different aspects of weld bead geometry for example depth of penetration (DOP), bead width (BW), depth to width ratio (D/W), and weld fusion zone area (WA) were investigated by using the central composite design (CCD). 9-12% Cr ferritic stainless steel (FSS) plates were welded using A-TIG welding. It was observed that all input variables have a direct influence on the DOP, BW, and D/W. However, flux coating density has no significant effect on WA. Mathematical models were generated from the obtained responses to predict the weld bead geometry. An optimized DOP, BW, D/W, and WA of 6.95 mm, 8.76 mm, 0.80, and 41.99 mm2 respectively, were predicted at the welding current of 213.78 A, the welding speed of 96.22 mm/min and the flux coating density of 1.99 mg/cm2. Conformity test was done to check the practicability of the developed models. The conformity test results were in good agreement with the predicted values. Arc constriction and reversal in Marangoni convection were considered as major mechanisms for the deep and narrow weld bead during A-TIG welding.
Manipulation of Weyl Points in Reciprocal and Nonreciprocal Mechanical Lattices
Creators: name: Tian, Mingsheng
name: Velkovsky, Ivan
name: Chen, Tao
name: Sun, Fengxiao
name: He, Qiongyi
name: Gadway, Bryce
Publisher: name: arXiv
Year: 2023
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We introduce feedback-measurement technologies to achieve flexible control of Weyl points and conduct the first experimental demonstration of Weyl type I-II transition in mechanical systems. We demonstrate that non-Hermiticity can expand the Fermi arc surface states from connecting Weyl points to Weyl rings, and lead to a localization transition of edge states influenced by the interplay between band topology and the non-Hermitian skin effect. Our findings offer valuable insights into the design and manipulation of Weyl points in mechanical systems, providing a promising avenue for manipulating topological modes in non-Hermitian systems.
title: CFPR: interview avec CAN2019_0036
Creators: name: Delafontaine, François
name: Avanzi, Mathieu
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021
Subjects: subject: Français
subject: fra

description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.3c37t5m6.v4#e45d8ef296687783acf471a5d3afbb0dd592d91f
Storage Modulus’ Variation in Aging and its Application in Assessing the Stability of Emulsion Explosive Matrix
Creators: name: Zhang, Kai-Ming
name: Zhao, Hai-Rong
name: Ou-Qi Ni
name: Ren, Xiao-Ming
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: An investigation was performed into the stability of bulk emulsion explosive matrix (BEEM) via studying on the variation of storage modulus in aging. The experimental results show that there is a tight relationship between storage modulus (G’) and the stability of BEEM. The increase of the amount of ammonium nitrate (AN) crystals in aging leads to the increase of G’. When the amount of AN crystals reaches a certain extent, the vastly destroyed microstructure results in the disappear of viscoelastic property of BEEM. The results demonstrated that the less growth ratio of G' causes a better stability of BEEM. The G' was used to investigate the effect of the nature of emulsifier and continuous phase on the stability of BEEM. It is found that the chemical structure of head group, the length of hydrophobic chain and the content of emulsifier affect the stability of BEEM. Besides that, the viscosity and polarity of continuous phase also have important effect on the stability of BEEM.
Non-Abelian Braiding of Topological Edge Bands
Creators: name: Long, Yang
name: Wang, Zihao
name: Zhang, Chen
name: Xue, Haoran
name: Zhao, Yuxin
name: Zhang, Baile
Publisher: name: arXiv
Year: 2024
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Braiding is a geometric concept that manifests itself in a variety of scientific contexts from biology to physics, and has been employed to classify bulk band topology in topological materials. Topological edge states can also form braiding structures, as demonstrated recently in a type of topological insulators known as Möbius insulators, whose topological edge states form two braided bands exhibiting a Möbius twist. While the formation of Möbius twist is inspiring, it belongs to the simple Abelian braid group $\mathbb{B}_2$. The most fascinating features about topological braids rely on the non-Abelianness in the higher-order braid group $\mathbb{B}_N$ ($N \geq 3$), which necessitates multiple edge bands, but so far it has not been discussed. Here, based on the gauge enriched symmetry, we develop a scheme to realize non-Abelian braiding of multiple topological edge bands. We propose tight-binding models of topological insulators that are able to generate topological edge states forming non-Abelian braiding structures. Experimental demonstrations are conducted in two acoustic crystals, which carry three and four braided acoustic edge bands, respectively. The observed braiding structure can correspond to the topological winding in the complex eigenvalue space of projective translation operator, akin to the previously established point-gap winding topology in the bulk of the Hatano-Nelson model. Our work also constitutes the realization of non-Abelian braiding topology on an actual crystal platform, but not based on the "virtual" synthetic dimensions.
title: CFPR: interview avec BEL2021_0009
Creators: name: Delafontaine, François
name: Avanzi, Mathieu
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.f1a9van4.v3#7185b3c2a8a5a46d43b00035a9be3f164ce019b0
Bounded flows of dense gases
Creators: name: Busuioc, Sergiu
name: Sofonea, Victor
Publisher: name: arXiv
Year: 2023
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: Numerical solutions of the Enskog equation obtained employing a Finite-Difference Lattice Boltzmann (FDLB) and a Direct Simulation Monte Carlo (DSMC)-like particle method (PM) are systematically compared to determine the range of applicability of the simplified Enskog collision operator implemented in the Lattice Boltzmann framework. Three types of bounded flows of dense gases - namely the Fourier, the Couette, and the Poiseuille flows - are investigated for a wide range of input parameters. For low to moderate reduced density, the proposed FDLB model exhibits commendable accuracy for all bounded flows tested in this study, with substantially lower computational cost than the PM method.
description: 44 pages, 13 figues
$J/ψ$ and $ψ$(2S) polarization in proton-proton collisions at energies available at the CERN Large Hadron Collider using PYTHIA8
Creators: name: Sahoo, Bhagyarathi
name: Sahu, Dushmanta
name: Deb, Suman
name: Singh, Captain R.
name: Sahoo, Raghunath
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Experiment (nucl-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The production mechanisms of charmonium states in both hadronic and heavy-ion collisions hold great significance for investigating the hot and dense QCD matter. Studying charmonium polarization in ultra-relativistic collisions can also provide insights into the underlying production mechanisms. With this motivation, we explore the $J/ψ$ and $ψ$(2S) polarization in proton+proton collisions at $\sqrt{s}$ = 7, 8, and 13 TeV using a pQCD-inspired Monte-Carlo event generator called PYTHIA8. This work considers reconstructed quarkonia through their dimuons decay channel in the ALICE forward rapidity acceptance range of $2.5 < y_{μμ} < 4$. Further, we calculate the polarization parameters $λ_θ$, $λ_ϕ$, $λ_{θϕ}$ from the polar and azimuthal angular distributions of the dimuons in helicity and Collins-Soper frames. This study presents a comprehensive measurement of the polarization parameters as a function of transverse momentum, charged-particle multiplicity, and rapidity at the LHC energies. Our findings of charmonium polarization are in qualitative agreement with the corresponding experimental data.
description: Same as the published version in Phys. Rev. C
Phase transition to chaos in complex ecosystems with non-reciprocal species-resource interactions
Creators: name: Blumenthal, Emmy
name: Rocks, Jason W.
name: Mehta, Pankaj
Publisher: name: arXiv
Year: 2023
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Non-reciprocal interactions between microscopic constituents can profoundly shape the large-scale properties of complex systems. Here, we investigate the effects of non-reciprocity in the context of theoretical ecology by analyzing a generalization of MacArthur's consumer-resource model with asymmetric interactions between species and resources. Using a mixture of analytic cavity calculations and numerical simulations, we show that such ecosystems generically undergo a phase transition to chaotic dynamics as the amount of non-reciprocity is increased. We analytically construct the phase diagram for this model and show that the emergence of chaos is controlled by a single quantity: the ratio of surviving species to surviving resources. We also numerically calculate the Lyapunov exponents in the chaotic phase and carefully analyze finite-size effects. Our findings show how non-reciprocal interactions can give rise to complex and unpredictable dynamical behaviors even in the simplest ecological consumer-resource models.
description: 5 pages, 4 figures; SI: 22 pages, 19 figures
Embedded unbounded order convergent sequences in topologically convergent nets in vector lattices
Creators: name: Deng, Yang
name: de Jeu, Marcel
Publisher: name: arXiv
Year: 2023
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics

description: We show that, for a class of locally solid topologies on vector lattices, a topologically convergent net has an embedded sequence that is unbounded order convergent to the same limit. Our result implies, and often improves, many of the known results in this vein in the literature. A study of metrisability and submetrisability of locally solid topologies on vector lattices is included.
description: 25 pages. Proposition 3.7 has been strengthened. Final version, to appear in Banach J. Math. Anal
Quantization of Axion-Gauge Couplings and Non-Invertible Higher Symmetries
Creators: name: Choi, Yichul
name: Forslund, Matthew
name: Lam, Ho Tat
name: Shao, Shu-Heng
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We derive model-independent quantization conditions on the axion couplings (sometimes known as the anomaly coefficients) to the Standard Model gauge group $[SU(3)\times SU(2)\times U(1)_Y]/\mathbb{Z}_q$ with $q=1,2,3,6$. Using these quantization conditions, we prove that any QCD axion model to the right of the $E/N=8/3$ line on the $|g_{aγγ}|$-$m_a$ plot must necessarily face the axion domain wall problem in a post-inflationary scenario. We further demonstrate the higher-group and non-invertible global symmetries in the Standard Model coupled to a single axion. These generalized global symmetries lead to universal bounds on the axion string tension and the monopole mass. If the axion were discovered in the future, our quantization conditions could be used to constrain the global form of the Standard Model gauge group.
description: 23+16 pages, 2 figures, 2 tables; v2: minor edits
Deterministic and non-volatile switching of all-van der Waals spin-orbit torque system above room temperature without external magnetic fields
Creators: name: Kajale, Shivam N.
name: Nguyen, Thanh
name: Li, Mingda
name: Sarkar, Deblina
Publisher: name: arXiv
Year: 2023
Subjects: subject: Applied Physics (physics.app-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Two-dimensional van der Waals (vdW) magnetic materials hold promise for the development of high-density, energy-efficient spintronic devices for memory and computation. Recent breakthroughs in material discoveries and spin-orbit torque (SOT) control of vdW ferromagnets have opened a path for integration of vdW magnets in commercial spintronic devices. However, a solution for field-free electric control of perpendicular magnetic anisotropy (PMA) vdW magnets at room temperatures, essential for building compact and thermally stable spintronic devices, is still missing. Here, we report the first demonstration of field-free deterministic and non-volatile switching of a PMA vdW ferromagnet, Fe$_3$GaTe$_2$ above room temperature (up to 320 K). We use the unconventional out-of-plane anti-damping torque from an adjacent WTe$_2$ layer to enable such switching with a low current density of $2.23 \times 10^6$ A/cm$^2$. This study exemplifies the efficacy of low-symmetry vdW materials for spin-orbit torque control of vdW ferromagnets and provides an all-vdW solution for the next generation of scalable and energy-efficient spintronic devices.
title: CFPR: interview avec BEL2020_0160
Creators: name: Delafontaine, François
name: Avanzi, Mathieu
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.1b5bmn74.v3#264728ea67bd214a34986b0171da087714136749
The druggable schizophrenia genome: from repurposing opportunities to unexplored drug targets.
Creators: name: Lago, Santiago G
name: Bahn, Sabine
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Review Article
/631/154/555
/692/699/476/1799
/631/154/433
/631/208/726
review-article

description: Funder: Stanley Medical Research Institute (SMRI); doi: https://doi.org/10.13039/100007123
description: There have been no new drugs for the treatment of schizophrenia in several decades and treatment resistance represents a major unmet clinical need. The drugs that exist are based on serendipitous clinical observations rather than an evidence-based understanding of disease pathophysiology. In the present review, we address these bottlenecks by integrating common, rare, and expression-related schizophrenia risk genes with knowledge of the druggability of the human genome as a whole. We highlight novel drug repurposing opportunities, clinical trial candidates which are supported by genetic evidence, and unexplored therapeutic opportunities in the lesser-known regions of the schizophrenia genome. By identifying translational gaps and opportunities across the schizophrenia disease space, we discuss a framework for translating increasingly well-powered genetic association studies into personalized treatments for schizophrenia and initiating the vital task of characterizing clinically relevant drug targets in underexplored regions of the human genome.
Speech-dependent Modeling of Own Voice Transfer Characteristics for In-ear Microphones in Hearables
Creators: name: Ohlenbusch, Mattes
name: Rollwage, Christian
name: Doclo, Simon
Publisher: name: arXiv
Year: 2023
Subjects: subject: Audio and Speech Processing (eess.AS)
subject: Sound (cs.SD)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: Many hearables contain an in-ear microphone, which may be used to capture the own voice of its user in noisy environments. Since the in-ear microphone mostly records body-conducted speech due to ear canal occlusion, it suffers from band-limitation effects while only capturing a limited amount of external noise. To enhance the quality of the in-ear microphone signal using algorithms aiming at joint bandwidth extension, equalization, and noise reduction, it is desirable to have an accurate model of the own voice transfer characteristics between the entrance of the ear canal and the in-ear microphone. Such a model can be used, e.g., to simulate a large amount of in-ear recordings to train supervised learning-based algorithms. Since previous research on ear canal occlusion suggests that own voice transfer characteristics depend on speech content, in this contribution we propose a speech-dependent system identification model based on phoneme recognition. We assess the accuracy of simulating own voice speech by speech-dependent and speech-independent modeling and investigate how well modeling approaches are able to generalize to different talkers. Simulation results show that using the proposed speech-dependent model is preferable for simulating in-ear recordings compared to using a speech-independent model.
description: Presented at Forum Acusticum 2023
MitoQ Inhibits Human Breast Cancer Cell Migration, Invasion and Clonogenicity.
Creators: name: Capeloa, Tania
name: Krzystyniak, Joanna
name: D'Hose, Donatienne
name: Canas Rodriguez, Amanda
name: Payen, Valery L
name: Zampieri, Luca X
name: Van De Velde, Justine A
name: Benyahia, Zohra
name: Pranzini, Erica
name: Vazeille, Thibaut
name: Fransolet, Maude
name: Bouzin, Caroline
name: Brusa, Davide
name: Michiels, Carine
name: Gallez, Bernard
name: Murphy, Mike
name: Porporato, Paolo E
name: Sonveaux, Pierre
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: breast cancer
migration
invasion
clonogenicity
spheroids
metastasis
mitochondria
mitochondrial superoxide
MitoQ
mitochondria-targeted antioxidant

description: To successfully generate distant metastases, metastatic progenitor cells must simultaneously possess mesenchymal characteristics, resist to anoïkis, migrate and invade directionally, resist to redox and shear stresses in the systemic circulation, and possess stem cell characteristics. These cells primarily originate from metabolically hostile areas of the primary tumor, where oxygen and nutrient deprivation, together with metabolic waste accumulation, exert a strong selection pressure promoting evasion. Here, we followed the hypothesis according to which metastasis as a whole implies the existence of metabolic sensors. Among others, mitochondria are singled out as a major source of superoxide that supports the metastatic phenotype. Molecularly, stressed cancer cells increase mitochondrial superoxide production, which activates the transforming growth factor-β pathway through src directly within mitochondria, ultimately activating focal adhesion kinase Pyk2. The existence of mitochondria-targeted antioxidants constitutes an opportunity to interfere with the metastatic process. Here, using aggressive triple-negative and HER2-positive human breast cancer cell lines as models, we report that MitoQ inhibits all the metastatic traits that we tested in vitro. Compared to other mitochondria-targeted antioxidants, MitoQ already successfully passed Phase I safety clinical trials, which provides an important incentive for future preclinical and clinical evaluations of this drug for the prevention of breast cancer metastasis.
title: CFPR: interview avec BEL2020_0159
Creators: name: Delafontaine, François
name: Avanzi, Mathieu
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.9ba0j181.v2#b027507864fe66d20a40bcf85fc40f9326fa38e4
Activation Compression of Graph Neural Networks using Block-wise Quantization with Improved Variance Minimization
Creators: name: Eliassen, Sebastian
name: Selvan, Raghavendra
Publisher: name: arXiv
Year: 2023
Subjects: subject: Machine Learning (stat.ML)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Efficient training of large-scale graph neural networks (GNNs) has been studied with a specific focus on reducing their memory consumption. Work by Liu et al. (2022) proposed extreme activation compression (EXACT) which demonstrated drastic reduction in memory consumption by performing quantization of the intermediate activation maps down to using INT2 precision. They showed little to no reduction in performance while achieving large reductions in GPU memory consumption. In this work, we present an improvement to the EXACT strategy by using block-wise quantization of the intermediate activation maps. We experimentally analyze different block sizes and show further reduction in memory consumption (>15%), and runtime speedup per epoch (about 5%) even when performing extreme extents of quantization with similar performance trade-offs as with the original EXACT. Further, we present a correction to the assumptions on the distribution of intermediate activation maps in EXACT (assumed to be uniform) and show improved variance estimations of the quantization and dequantization steps.
description: Accepted to be presented at the International Conference on Acoustics, Speech and Signal Processing (ICASSP-2024). Source code at https://github.com/saintslab/i-Exact
A Synthetic Route for the Novel Pyrimidine-Substituted Alkanoate, Acetohydrazide and Imines: Synthon for β-lactams
Creators: name: Preety Saini
name: Bari, Shamsher S.
name: Bimal K. Banik
name: Bhalla, Aman
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Plant Biology

description: A simple and efficient synthesis of novel pyrimidine-substituted alkanoate, acetohydrazide and imines is described. The synthesis of novel ethyl 2-(2,6-dimethylpyrimidin-4-yloxy)acetate (EDMPyA) 2 was carried out via SN2 O-alkylation of 2,6-dimethyl-4-hydroxypyrimidine (DMHPy) 1 with ethyl haloacetate. The compound EDMPyA 2 was subjected to nucleophilic substitution reaction with hydrazine hydrate to afford novel 2-(2,6-dimethylpyrimidin-4-yloxy)acetohydrazide (DMPyAH) 3. This DMPyAH 3 upon condensation with differently substituted carbonyl compounds (aldehydes/ ketones) furnished 2-(2,6-dimethylpyrimidin-4-yloxy)acetohydrazide imines (DMPyAH-I) 4a-d. These imines can be used for the preparation of unique β-lactams. The structure elucidation of all the newly synthesized compounds was carried out using spectroscopy (FT-IR, 1H and 13C NMR) and elemental analysis (C, H, N)
title: CFPR: interview avec BEL2020_0158
Creators: name: Delafontaine, François
name: Avanzi, Mathieu
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.1f4ernm0.v3#253af9e61c34f4ae584ece653d3e9780764ee270
Exploring docking methods for virtual screening: application to the identification of neuraminidase and Ftsz potential inhibitors
Creators: name: Soulère, Laurent
name: Soulage, Christophe O.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Virtual screenings based on molecular docking play a major role in medicinal chemistry for the identification of new bioactive molecules. For this purpose, several docking methods can be used. Here, using Arguslab as software and a Gold Platinum subset library of commercially available compounds from Asinex, two docking methods associated to the scoring function Ascore were employed to investigate virtual screenings. One method is based on a genetic algorithm and the other based on a shape-based method. As case studies, both docking techniques were explored by targeting the PC190723 binding site of FtsZ protein from Staphylococcus aureus and the active site of N8 neuraminidase from Influenza virus. Following four docking sequences for each docking engine, the genetic algorithm led to multiple docking results, whereas the shape-based method gave reproducible results. The present study shows that the stochastic nature of the genetic algorithm will require the biological evaluation of more compounds than the shape-based method. This study showed that both methods are complementary and also led to the identification of neuraminidase and FtsZ potential inhibitors.