cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent
Creators: name: Willis, Nicky J
name: Bayle, Elliott D
name: Papageorgiou, George
name: Steadman, David
name: Atkinson, Benjamin N
name: Mahy, William
name: Fish, Paul V
Publisher: name: The Francis Crick Institute
Year: 2020
Subjects: Chemical Biology & High Throughput
Structural Biology & Biophysics

description: Background: The carboxylesterase Notum has been shown to act as a key negative regulator of the Wnt signalling pathway by mediating the depalmitoleoylation of Wnt proteins. LP-922056 (1) is an orally active inhibitor of Notum. We are investigating the role of Notum in modulating Wnt signalling in the central nervous system and wished to establish if 1 would serve as a peripherally restricted control. An accessible and improved synthetic route would allow 1 to become more readily available as a chemical tool to explore the fundamental biology of Notum and build target validation to underpin new drug discovery programs. Results: An improved, scalable synthesis of 1 is reported. Key modifications include: (1) the introduction of the C7-cyclopropyl group was most effectively achieved with a Suzuki-Miyaura cross-coupling reaction with MIDA-boronate 11 (5 → 6), and (2) C6 chlorination was performed with 1-chloro-1,2-benziodoxol-3-one (12) (6 → 7) as a mild and selective electrophilic chlorination agent. This 7-step route from 16 has been reliably performed on large scale to produce multigram quantities of 1 in good efficiency and high purity. Pharmacokinetic studies in mouse showed CNS penetration of 1 is very low with a brain/plasma concentration ratio of just 0.01. A small library of amides 17 were prepared from acid 1 to explore if 1 could be modified to deliver a CNS penetrant tool by capping off the acid as an amide. Although significant Notum inhibition activity could be achieved, none of these amides demonstrated the required combination of metabolic stability along with cell permeability without evidence of P-gp mediated efflux. Conclusion: Mouse pharmacokinetic studies demonstrate that 1 is unsuitable for use in models of disease where brain penetration is an essential requirement of the compound but would be an ideal peripherally restricted control. These data will contribute to the understanding of drug levels of 1 to overlay with appropriate in vivo efficacy endpoints, i.e., the PK-PD relationship. The identification of a suitable analogue of 1 (or 17) which combines Notum inhibition with CNS penetration would be a valuable chemical probe for investigating the role of Notum in disease models.
Pycobra: A Python Toolbox for Ensemble Learning and Visualisation
Creators: name: Guedj, Benjamin
name: Desikan, Bhargav Srinivasa
Publisher: name: arXiv
Year: 2017
Subjects: subject: Computation (stat.CO)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: We introduce \texttt{pycobra}, a Python library devoted to ensemble learning (regression and classification) and visualisation. Its main assets are the implementation of several ensemble learning algorithms, a flexible and generic interface to compare and blend any existing machine learning algorithm available in Python libraries (as long as a \texttt{predict} method is given), and visualisation tools such as Voronoi tessellations. \texttt{pycobra} is fully \texttt{scikit-learn} compatible and is released under the MIT open-source license. \texttt{pycobra} can be downloaded from the Python Package Index (PyPi) and Machine Learning Open Source Software (MLOSS). The current version (along with Jupyter notebooks, extensive documentation, and continuous integration tests) is available at \href{https://github.com/bhargavvader/pycobra}{https://github.com/bhargavvader/pycobra} and official documentation website is \href{https://modal.lille.inria.fr/pycobra}{https://modal.lille.inria.fr/pycobra}.
Cross-stream migration of active particles
Creators: name: Katuri, Jaideep
name: Uspal, William E.
name: Simmchen, Juliane
name: Miguel-López, Albert
name: Sánchez, Samuel
Publisher: name: arXiv
Year: 2017
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: For natural microswimmers, the interplay of swimming activity and external flow can promote robust motion, e.g. propulsion against ("upstream rheotaxis") or perpendicular to the direction of flow. These effects are generally attributed to their complex body shapes and flagellar beat patterns. Here, using catalytic Janus particles as a model experimental system, we report on a strong directional response that occurs for spherical active particles in a channel flow. The particles align their propulsion axes to be nearly perpendicular to both the direction of flow and the normal vector of a nearby bounding surface. We develop a deterministic theoretical model of spherical microswimmers near a planar wall that captures the experimental observations. We show how the directional response emerges from the interplay of shear flow and near-surface swimming activity. Finally, adding the effect of thermal noise, we obtain probability distributions for the swimmer orientation that semi-quantitatively agree with the experimental distributions.
title: ADCO, Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Cart. 32 (G 136), 745 folios, f. 0634
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 0634, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 0634, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Morphological and optical properties of PdxAg1-x alloy nanoparticles
Creators: name: Sundar Kunwar
name: Puran Pandey
name: Sui, Mao
name: Bastola, Sushil
name: Jihoon Lee
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology

description: Alloy nanoparticles (NPs) can offer a wide range of opportunities for various applications due to their composition and structure dependent properties such as multifunctionality, electronic heterogeneity, site-specific response, and multiple plasmon resonance bands. In this work, the fabrication of self-assembled PdxAg1-x NPs alloy nanostructures with distinct size, density, shape, and composition is demonstrated via the solid-state dewetting of sputtered Pd/Ag thin films on c-plane sapphire. The initial stage of bilayer dewetting exhibits the nucleation of voids, followed by the expansion of voids and cluster breakdown and finally shape transformation along with the temperature control. Bilayer composition shows a substantial influence on the dewetting such that the overall dewetting is enhanced along with the increased Ag composition, i.e. Pd0.25Ag0.75 > Pd0.5Ag0.5 > Pd0.75Ag0.25. On the other hand, the size and density of NPs can be efficiently controlled by varying the initial thickness of bilayers. Reflectance peaks in UV and near-infrared (NIR) regions and a wide absorption band in the visible region arisen from the surface plasmon resonance are observed in reflectance spectra. The peak intensity depends on the composition of PdxAg1-x NPs and the NIR peaks gradually blue-shift with the size decrement.
Depth and regularity modulo a principal ideal
Creators: name: Caviglia, Giulio
name: Ha, Huy Tai
name: Herzog, Jürgen
name: Kummini, Manoj
name: Terai, Naoki
name: Trung, Ngo Viet
Publisher: name: arXiv
Year: 2017
Subjects: subject: Commutative Algebra (math.AC)
subject: Algebraic Geometry (math.AG)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 13C20 (Primary), 13D45, 14B05, 05C65 (Secondary)

description: We study the relationship between depth and regularity of a homogeneous ideal I and those of (I,f) and I:f, where f is a linear form or a monomial. Our results has several interesting consequences on depth and regularity of edge ideals of hypegraphs and of powers of ideals.
description: 20 pages, published version, Journal of Algebraic Combinatorics 2018
On the Gevrey ultradifferentiability of weak solutions of an abstract evolution equation with a scalar type spectral operator on the open semi-axis
Creators: name: Markin, Marat V.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 34G10, 47B40, 30D60 (Primary), 47B15, 47D06, 47D60 (Secondary)

description: Given the abstract evolution equation \[ y'(t)=Ay(t),\ t\ge 0, \] with scalar type spectral operator $A$ in a complex Banach space, found are conditions necessary and sufficient for all weak solutions of the equation, which a priori need not be strongly differentiable, to be strongly Gevrey ultradifferentiable of order $β\ge 1$, in particular analytic or entire, on the open semi-axis $(0,\infty)$. Also, revealed is a certain interesting inherent smoothness improvement effect.
description: Rewritten abstract, minor corrections and readability improvements, updated bibliography. arXiv admin note: substantial text overlap with arXiv:1706.08014
A morphogenetic EphB/EphrinB code controls hepatopancreatic duct formation.
Creators: name: M Ilcim Thestrup
name: Caviglia, Sara
name: Cayuso, Jordi
name: Heyne, Ronja LS
name: Ahmad, Racha
name: Hofmeister, Wolfgang
name: Satriano, Letizia
name: Wilkinson, David G
name: Andersen, Jesper B
name: Ober, Elke A
Publisher: name: The Francis Crick Institute
Year: 2020
Subjects: subject: Neurosciences
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Human Biology & Physiology
subject: Stem Cells
subject: Model organisms

description: The hepatopancreatic ductal (HPD) system connects the intrahepatic and intrapancreatic ducts to the intestine and ensures the afferent transport of the bile and pancreatic enzymes. Yet the molecular and cellular mechanisms controlling their differentiation and morphogenesis into a functional ductal system are poorly understood. Here, we characterize HPD system morphogenesis by high-resolution microscopy in zebrafish. The HPD system differentiates from a rod of unpolarized cells into mature ducts by de novo lumen formation in a dynamic multi-step process. The remodeling step from multiple nascent lumina into a single lumen requires active cell intercalation and myosin contractility. We identify key functions for EphB/EphrinB signaling in this dynamic remodeling step. Two EphrinB ligands, EphrinB1 and EphrinB2a, and two EphB receptors, EphB3b and EphB4a, control HPD morphogenesis by remodeling individual ductal compartments, and thereby coordinate the morphogenesis of this multi-compartment ductal system.
Unstable polarized del Pezzo surfaces
Creators: name: Cheltsov, Ivan
name: Martinez-Garcia, Jesus
Publisher: name: arXiv
Year: 2017
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 32Q20, 32Q26, 14J45, 14J26, 32Q15

description: We provide new examples of K-unstable polarized smooth del Pezzo surfaces using a flopped version first used by Cheltsov and Rubinstein of the test configurations introduced by Ross and Thomas. As an application, we provide new obstructions for the existence of constant scalar curvature Kahler metrics on polarized smooth del Pezzo surfaces.
description: 102 pages, from which 64 pages are an appendix with symbolic computations. To appear in Trans. Amer. Math. Soc
Parton model description of multiparticle azimuthal correlations in $pA$ collisions
Creators: name: Dusling, Kevin
name: Mace, Mark
name: Venugopalan, Raju
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: In arXiv:1705.00745, an initial state "parton model" of quarks scattering off a dense nuclear target was shown to qualitatively reproduce the systematics of multiparticle azimuthal anisotropy cumulants measured in proton/deuteron-nucleus ($pA$) collisions at RHIC and the LHC. The systematics included i) the behavior of the four-particle cumulant $c_2\{4\}$, which generates a real four-particle second Fourier harmonic $v_2\{4\}$, ii) the ordering $v_2\{2\}>v_2\{4\}\approx v_2\{6\}\approx v_2\{8\}$ for two-, four-, six-, and eight-particle Fourier harmonics, iii) the behavior of so-called symmetric cumulants $\text{SC}(2,3)$ and $\text{SC}(2,4)$. These features of azimuthal multiparticle cumulants were previously interpreted as a signature of hydrodynamic flow; our results challenge this interpretation. We expand here upon our previous study and present further details and novel results on the saturation scale and transverse momentum ($p_\perp$) dependence of multiparticle azimuthal correlations. We find that the dependence of $v_2\{2\}$ and $v_2\{4\}$ on the number of color domains in the target varies with the $p_\perp$ window explored. We extend our prior discussion of symmetric cumulants and compute as yet unmeasured symmetric cumulants. We investigate the $N_c$ dependence of $v_2\{2\}$ and $v_2\{4\}$. We contrast our results, which include multiple scatterings of each quark off the target, to the Glasma graph approximation, where each quark suffers at most two gluon exchanges with the target. We find that coherent multiple scattering is essential to obtain a positive definite $v_2\{4\}$. We provide an algorithm to compute expectation values of arbitrary products of the "dipole" lightlike Wilson line correlators.
description: 26 pages, 22 figures, 1 appendix. v2: Further discussions and references added; version accepted for publication in Phys. Rev. D
Uma novela, um filme, o amor e a morte em Veneza
Creators: name: Marchezan, Luiz Gonzaga
Publisher: name: Forma Breve
Year: 2013

description: Este artigo compara a novela A morte em Veneza, de Thomas Mann, com sua versão cinematográfica, dirigida por Luchino Visconti.
description: Forma Breve, n.º 10 (2013): A novela
Positive scalar curvature and higher-dimensional families of Seiberg-Witten equations
Creators: name: Konno, Hokuto
Publisher: name: arXiv
Year: 2017
Subjects: subject: Differential Geometry (math.DG)
subject: Geometric Topology (math.GT)
subject: FOS: Mathematics

description: We introduce an invariant of tuples of commutative diffeomorphisms on a 4-manifold using families of Seiberg-Witten equations. This is a generalization of Ruberman's invariant of diffeomorphisms defined using 1-parameter families of Seiberg-Witten equations. Our invariant yields an application to the homotopy groups of the space of positive scalar curvature metrics on a 4-manifold. We also study the extension problem for families of 4-manifolds using our invariant.
description: 22 pages, accepted for publication by the Journal of Topology
Niketche: um discurso de negociação de uma identidade nova para a mulher moçambicana do século XXI
Creators: name: Francisco, Helga Maria Pinto
Publisher: name: Forma Breve
Year: 2012

description: O romance niketche, da autora moçambicana Paulina Chiziane, constitui -se a partir de um conjunto de discursos subversivos colocados na voz de uma narradora – personagem que parte em busca de uma identidade nova para a mulher moçambicana do século XXI, em oposição à milenar identidade doméstica para si construída por uma sociedade dominantemente patriarcal.
description: Forma Breve, n.º 9 (2012): Conto interpolado: ciclo de contos
A Comparison of Resampling and Recursive Partitioning Methods in Random Forest for Estimating the Asymptotic Variance Using the Infinitesimal Jackknife
Creators: name: Brokamp, Cole
name: Rao, MB
name: Ryan, Patrick
name: Jandarov, Roman
Publisher: name: arXiv
Year: 2017
Subjects: subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: The infinitesimal jackknife (IJ) has recently been applied to the random forest to estimate its prediction variance. These theorems were verified under a traditional random forest framework which uses classification and regression trees (CART) and bootstrap resampling. However, random forests using conditional inference (CI) trees and subsampling have been found to be not prone to variable selection bias. Here, we conduct simulation experiments using a novel approach to explore the applicability of the IJ to random forests using variations on the resampling method and base learner. Test data points were simulated and each trained using random forest on one hundred simulated training data sets using different combinations of resampling and base learners. Using CI trees instead of traditional CART trees as well as using subsampling instead of bootstrap sampling resulted in a much more accurate estimation of prediction variance when using the IJ. The random forest variations here have been incorporated into an open source software package for the R programming language.
Non-clinical pharmacokinetic profiles of rovatirelin, an orally available thyrotropin-releasing hormone analogue
Creators: name: Kobayashi, Kaoru
name: Abe, Yoshikazu
name: Harada, Hiroshi
name: Oota, Emiko
name: Endo, Takuro
name: Takeda, Hiroo
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: 1. The non-clinical pharmacokinetic profiles of rovatirelin, a novel thyrotropin-releasing hormone (TRH) analogue, were investigated in vivo and in vitro. 2. Rovatirelin orally administered to rats and dogs was rapidly absorbed and bioavailability was estimated to be 7.3 and 41.3%, respectively. The extent of plasma protein binding of rovatirelin in rats, dogs, and humans was low in all species (∼15%). The permeability of rovatirelin from blood to brain (permeability-surface area) ranged from 1.04 ± 0.14 to 1.29 ± 0.28 μL/min/g in rats, and rovatirelin was stable in rat plasma and brain homogenates. 3. The metabolite pattern was qualitatively similar in vitro and in vivo. In animals, rovatirelin aminopentanoic acid (rovatirelin-acid), rovatirelin aminopentanone (rovatirelin-ketone), rovatirelin pyrrolidine (4S)-hydroxy (rovatirelin-OH), (thiazoylalanyl)methylpyrrolidine (TAMP), 3-(4-thiazoyl)-l-alanine (TA), and unknown metabolites were observed. In human hepatocytes, TAMP was mainly formed and no unique human metabolite was observed. 4. The radioactivity from administered [14C]rovatirelin was predominantly excreted in faeces in rats and dogs, and almost all radioactivity was recovered 168 h after administration. Absorption, brain penetration, and stability of rovatirelin in the brain were greater than for taltirelin. 5. Thus, orally administered rovatirelin is a potentially improved treatment for spinocerebellar degeneration compared with taltirelin.
Developing statistical literacy and numeracy in journalists for health risk communication
Creators: name: Fallon, Eleanor
Publisher: name: University of Limerick
Year: 2024
Subjects: classificationCode: 49
subject: Mathematical sciences

description: The public’s perception of health risks can be influenced by the media, so journalists play a vital role in the communication of health risks to society. Numeracy and statistical literacy are important skills for health literacy and data literacy. However, previous literature has found that some journalists and journalism students have low numeric confidence levels and a wide range of numeric abilities. Some journalists also report having maths anxiety. The aim of this thesis was to improve journalism students’ statistical literacy and numeracy levels to support effective health risk communication. First, we investigated journalism students’ subjective and objective numeracy levels, their interpretation of qualitative descriptors of risks and their preference for health risk communication. We found that most students had low to moderate levels of numeric confidence and a range of objective numeric abilities, with some performing well. We also identified an area of numeracy that some students struggled with, i.e. relative risk. The results informed the development of an education intervention with journalism students. We tested the impact of this intervention using a before-and-after study, and improvements were observed in both numeric confidence and ability to interpret medical statistics. Qualitative feedback supported our findings, with participants reporting an increase in self-efficacy. We also created and implemented an evaluation framework for a well-established education intervention for health journalists in practice in the United States to improve their ability to interpret and reliably report the results of medical research. We compared the statistical literacy and numeracy levels of the two groups and the impact of the interventions. We found that both interventions increased numeric confidence levels and ability to interpret medical statistics. Additionally, our short education intervention for journalism students resulted in a similar increase in ability to interpret medical statistics as a longer one. Overall, this research can contribute to appropriate and responsible reporting of health research by journalists, which can support the public in making informed decisions on their health and well-being.
Genetic variant in microRNA-146a gene is associated with risk of rheumatoid arthritis
Creators: name: Zhang, Lin-Lin
name: Wu, Xiao-Xiao
name: Wang, Xu-Fan
name: Di, Dong-Sheng
name: Huang, Qian
name: Liu, Rui-Shan
name: Shuai, Zong-Wen
name: Ye, Dong-Qing
name: Leng, Rui-Xue
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: To investigated the association between single nucleotide polymorphisms (SNPs) in microRNA-146a (miR-146a) gene and susceptibility of rheumatoid arthritis (RA). We systemically extracted the genetic data of miR-146a from previous genome-wide association studies (GWASs) of RA. Subsequently, we performed a replication study in an independent Chinese cohort for selected variant. A meta-analysis combined the previous GWASs with the replication study was also conducted. The epigenetic annotation and cytokine assay were used for exploring potential variant function. The extracted genetic association data from three previous GWASs showed that the allele T of functional SNP rs2431697 increased RA susceptibility. The significant association for the SNP was also found in the Chinese replication cohort (OR = 1.24, 95% CI = 1.06–1.46, p = 8.69E-03). The estimated effect size for this SNP was larger in Asian population than that in European population (Asian meta-analysis: OR = 1.15, 95% CI = 1.09–1.22, p = 4.37E-07; Tran-ethnic meta-analysis: OR = 1.07, 95% CI = 1.04–1.10, p = 1.79E-06). The cytokine assay also showed that the risk allele T of the SNP rs2431697 is inversely associated with plasma TNF-α levels in health controls (p = .016). In summary, this study supports that genetic variant in miR-146a gene is associated with RA risk.KEY MESSAGESThe association between SNPs in miR-146a gene and susceptibility of RA was unclear.We investigated the genetic association using GWASs data and a replication study.The SNP rs2431697 in miR-146a gene is associated with RA risk. The association between SNPs in miR-146a gene and susceptibility of RA was unclear. We investigated the genetic association using GWASs data and a replication study. The SNP rs2431697 in miR-146a gene is associated with RA risk.
title: ADCO, Cartulaire de Cîteaux pour les domaines de Beaune (XVe siècle), Cart. 177 (11 H 289), 197 folios, f. 0245
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2015
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Cartulaire de Cîteaux pour les domaines de Beaune (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 177 (11 H 289), 197 folios, f. 0245, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les possessions d’Izeure (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 177 (11 H 289), 197 folios, f. 0245, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Comparing cyclotomic structures on different models for topological Hochschild homology
Creators: name: Dotto, Emanuele
name: Malkiewich, Cary
name: Patchkoria, Irakli
name: Sagave, Steffen
name: Woo, Calvin
Publisher: name: arXiv
Year: 2017
Subjects: subject: Algebraic Topology (math.AT)
subject: K-Theory and Homology (math.KT)
subject: FOS: Mathematics
subject: 19D55, 55Q91, 55P43

description: The topological Hochschild homology $THH(A)$ of an orthogonal ring spectrum $A$ can be defined by evaluating the cyclic bar construction on $A$ or by applying Bökstedt's original definition of $THH$ to $A$. In this paper, we construct a chain of stable equivalences of cyclotomic spectra comparing these two models for $THH(A)$. This implies that the two versions of topological cyclic homology resulting from these variants of $THH(A)$ are equivalent.
description: v2: 26 pages, exposition improved. Accepted for publication by the Journal of Topology
Additional file 5: of Differences in flavonoid pathway metabolites and transcripts affect yellow petal colouration in the aquatic plant Nelumbo nucifera
Creators: name: Zhu, Huan-huan
name: Yang, Ju-xiang
name: Xiao, Chu-han
name: Mao, Tian-yu
name: Zhang, Jie
name: Zhang, Hong-yan
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Figure S1. Heatmap showing secondary metabolites and their derivatives dynamics during flower coloration of a MLQS and b YGB. The proportion of each secondary metabolites and their derivatives in all periods from minimal to maximum are colored from blue to red. (PDF 1058 kb)
Supplementation of EPA and DHA in pregnant women with type 1 diabetes mellitus
Creators: name: Ivanisevic, Marina
name: Horvaticek, Marina
name: Delmis, Karlo
name: Delmis, Josip
Publisher: name: Taylor & Francis
Year: 2021
Subjects: Biochemistry
Medicine
Cell Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Developmental Biology
Mental Health

description: Lower proportions of n-3 PUFAs have been observed in neonates born to diabetic mothers. We aimed to investigate the association between DHA and EPA supplementation during pregnancy complicated with type 1 diabetes on concentration and proportion of fatty acids in maternal and foetal blood. We conducted a prospective randomized, single-blinded, placebo-controlled trial of 111 eligible pregnant women with type 1 diabetes and presented the results of 84 (intervention arm and control arm comprised 42 participants each) of them who successfully finished the trial in an academic hospital. The initiation of EPA and DHA supplementation or placebo started at randomization visit on gestational week 11–12. Blood samples were taken on the first (screening) visit to the clinic (1st trimester, between 8th and 10th gestational week, GW), then in the second trimester (19–24th GW) and third trimester (30th–33rd GW). On the delivery day, a blood sample was taken on fasting just before birth. The umbilical vein blood sample was taken shortly after the delivery. We found a significant increase in the intervention group when compared the first and the third trimester for n-3 PUFAs concentration, 4.3 mg/L (3.3–7.6): 10.0 mg/L (7.1–13.7), p < .001. In the intervention group, the concentration of DHA in maternal vein serum was 11.4 mg/L (7.7–17.5), and in umbilical vein serum, it was 5.1 mg/L (3.0–7.7), which was significantly higher than that in the control group, maternal vein serum: median 9.2 mg/L(6.0–12.3), p = .03 and umbilical vein serum: median 3.4 mg/L (2.1–5.6), p = .009. The increased weight gain in pregnancy and concentration and proportions of DHA, n-3 PUFAs with a decreased proportion of AA, n-6 PUFAs, and AA/DHA ratio in maternal and umbilical vein serum summarize the effect of supplementation with EPA and DHA.
Context encoding enables machine learning-based quantitative photoacoustics
Creators: name: Kirchner, Thomas
name: Gröhl, Janek
name: Maier-Hein, Lena
Publisher: name: arXiv
Year: 2017
Subjects: subject: Medical Physics (physics.med-ph)
subject: Machine Learning (cs.LG)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Real-time monitoring of functional tissue parameters, such as local blood oxygenation, based on optical imaging could provide groundbreaking advances in the diagnosis and interventional therapy of various diseases. While photoacoustic (PA) imaging is a novel modality with great potential to measure optical absorption deep inside tissue, quantification of the measurements remains a major challenge. In this paper, we introduce the first machine learning based approach to quantitative PA imaging (qPAI), which relies on learning the fluence in a voxel to deduce the corresponding optical absorption. The method encodes relevant information of the measured signal and the characteristics of the imaging system in voxel-based feature vectors, which allow the generation of thousands of training samples from a single simulated PA image. Comprehensive in silico experiments suggest that context encoding (CE)-qPAI enables highly accurate and robust quantification of the local fluence and thereby the optical absorption from PA images.
description: under review JBO
O sentimento de açorianidade
Creators: name: Gonçalves, Adelto
Publisher: name: Forma Breve
Year: 2012

description: Pouco estudada e conhecida, especialmente no Brasil, apesar dos muitos imigrantes que para as regiões Sul e Sudeste vieram ao final do século XIX e na primeira metade do século XX, a literatura de temática açoriana ainda aguarda o surgimento de estudos teóricos e crítico -literários na universidade brasileira, embora não sejam raros os descendentes daqueles pioneiros – na maioria, analfabetos ou semialfabetizados – que já alcançaram os graus de mestre e doutor. No Brasil, destaca -se o romancista gaúcho Luiz Antonio de Assis Brasil (1945), professor da Pontifícia Universidade Católica (PUC) do Rio Grande do Sul e doutor em Letras, autor de escritos açorianos: a Viagem de Retorno – tópicos acerca da narrativa açoriana pós ‑25 de abril, ensaios (Lisboa, Salamandra, 2003) e de uma vasta obra que inclui outros livros, alguns publicados também em Portugal, Espanha e França.(...)
description: Forma Breve, n.º 9 (2012): Conto interpolado: ciclo de contos
Online codes for analog signals
Creators: name: Schulman, Leonard J.
name: Srivastava, Piyush
Publisher: name: arXiv
Year: 2017
Subjects: subject: Discrete Mathematics (cs.DM)
subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: This paper revisits a classical scenario in communication theory: a waveform sampled at regular intervals is to be encoded so as to minimize distortion in its reconstruction, despite noise. This transformation must be online (causal), to enable real-time signaling; and should use no more power than the original signal. The noise model we consider is an "atomic norm" convex relaxation of the standard (discrete alphabet) Hamming-weight-bounded model: namely, adversarial $\ell_1$-bounded. In the "block coding" (noncausal) setting, such encoding is possible due to the existence of large almost-Euclidean sections in $\ell_1$ spaces, a notion first studied in the work of Dvoretzky in 1961. Our main result is that an analogous result is achievable even causally. Equivalently, our work may be seen as a "lower triangular" version of $\ell_1$ Dvoretzky theorems. In terms of communication, the guarantees are expressed in terms of certain time-weighted norms: the time-weighted $\ell_2$ norm imposed on the decoder forces increasingly accurate reconstruction of the distant past signal, while the time-weighted $\ell_1$ norm on the noise ensures vanishing interference from distant past noise. Encoding is linear (hence easy to implement in analog hardware). Decoding is performed by an LP analogous to those used in compressed sensing.
Heterogeneity of estrogen receptor α and progesterone receptor distribution in lesions of deep infiltrating endometriosis of untreated women or during exposure to various hormonal treatments
Creators: name: Brichant, Géraldine
name: Nervo, Patricia
name: Albert, Adelin
name: Munaut, Carine
name: Jean-Michel Foidart
name: Nisolle, Michelle
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Deep infiltrating endometriosis (DIE) responds variably to hormonal therapy. Mutations in cancer driver genes have been identified in a fraction of the ectopic endometrial epithelial cells, suggesting a functional heterogeneity of these lesions. To evaluate the phenotype heterogeneity of cells in DIE, we measured the expression of estrogen receptor α (ERα) and of progesterone receptor (PR) in DIE of untreated women or under various treatments. We analyzed the luminal epithelial height (LEH), immunoreactive epithelial staining (IRS) and stromal staining intensity (SSI) of ERα and PR. We observed a high variability in the same gland, among distinct glands in the same sample and among distinct patients receiving the same treatment. LEH variability was primarily due to epithelial cells heterogeneity in a gland, secondarily to the glands randomly evaluated on the same section, and tertiary to the patient category. Variability in IRS and SSI scores was primarily the consequence of their heterogeneity in the same woman and to a lesser extent to variability among patients. LEH and SSI were not modified according to treatment. IRS for PR was lower in treated patients. This heterogeneity of ERα and PR distribution could explain why endocrine treatments are unable to cure this condition.
Alvis-Curtis Duality for Finite General Linear Groups and a Generalized Mullineux Involution
Creators: name: Dudas, Olivier
name: Jacon, Nicolas
Publisher: name: arXiv
Year: 2017
Subjects: subject: Representation Theory (math.RT)
subject: FOS: Mathematics

description: We study the effect of Alvis-Curtis duality on the unipotent representations of $\mathrm{GL}_n(q)$ in non-defining characteristic $\ell$. We show that the permutation induced on the simple modules can be expressed in terms of a generalization of the Mullineux involution on the set of all partitions, which involves both $\ell$ and the order of $q$ modulo $\ell$.
Social Clustering in Epidemic Spread on Coevolving Networks
Creators: name: Lee, Hsuan-Wei
name: Malik, Nishant
name: Shi, Feng
name: Mucha, Peter J.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Social and Information Networks (cs.SI)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Even though transitivity is a central structural feature of social networks, its influence on epidemic spread on coevolving networks has remained relatively unexplored. Here we introduce and study an adaptive SIS epidemic model wherein the infection and network coevolve with non-trivial probability to close triangles during edge rewiring, leading to substantial reinforcement of network transitivity. This new model provides a unique opportunity to study the role of transitivity in altering the SIS dynamics on a coevolving network. Using numerical simulations and Approximate Master Equations (AME), we identify and examine a rich set of dynamical features in the new model. In many cases, the AME including transitivity reinforcement provides accurate predictions of stationary-state disease prevalences and network degree distributions. Furthermore, for some parameter settings, the AME accurately trace the temporal evolution of the system. We show that higher transitivity reinforcement in the model leads to lower levels of infective individuals in the population, when closing a triangle is the dominant rewiring mechanism. These methods and results may be useful in developing ideas and modeling strategies for controlling SIS type epidemics.
description: 16 pages, 21 figures
O conto de Dina Salústio: um marco na literatura cabo -verdiana
Creators: name: Caputo Gomes, Simone
Publisher: name: Forma Breve
Year: 2012

description: Os contos de Dina Salústio, reunidos em Mornas eram as noites, lançam novas perspectivas para a série literária cabo -verdiana ao desenhar um retrato crítico da sociedade contemporânea que os textos evocam e em que se inserem. A discussão da problemática social de gênero, fundamental suporte à leitura dessas narrativas breves, busca desmascarar as contradições baseadas em estereótipos e preconceitos para, implodindo-os com uma linguagem incisiva e concentrada, propor outros caminhos para a realização do ser humano.
description: Forma Breve, n.º 9 (2012): Conto interpolado: ciclo de contos
A Radial Time Projection Chamber for $α$ detection in CLAS at JLab
Creators: name: Dupré, R.
name: Stepanyan, S.
name: Hattawy, M.
name: Baltzell, N.
name: Hafidi, K.
name: Battaglieri, M.
name: Bueltmann, S.
name: Celentano, A.
name: De Vita, R.
name: Alaoui, A. El
name: Fassi, L. El
name: Fenker, H.
name: Kosheleva, K.
name: Kuhn, S.
name: Musico, P.
name: Minutoli, S.
name: Oliver, M.
name: Perrin, Y.
name: Torayev, B.
name: Voutier, E.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: A new Radial Time Projection Chamber (RTPC) was developed at the Jefferson Laboratory to track low-energy nuclear recoils for the purpose of measuring exclusive nuclear reactions, such as coherent Deeply Virtual Compton Scattering and coherent meson production off $^4$He. In such processes, the $^4$He nucleus remains intact in the final state, however the CEBAF Large Acceptance Spectrometer (CLAS) cannot track the low energy $α$ particles. In 2009, we carried out measurements using the CLAS spectrometer supplemented by the RTPC positioned directly around a gaseous $^4$He target, allowing a detection threshold as low as 12$\sim$MeV for $^4$He. This article discusses the design, principle of operation, calibration methods and the performances of this RTPC.
Additional file 1 of Epidemiological characteristics of neuroendocrine neoplasms in Beijing: a population-based retrospective study
Creators: name: Chi, Yujia
name: Liu, Shuo
name: Zhang, Jianwei
name: Li, Huichao
name: Yang, Lei
name: Zhang, Xi
name: Li, Haoxin
name: Li, Qingyu
name: Wang, Ning
name: Lu, Ming
name: Zhuo, Minglei
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: Supplementary Material 1.
УСТРОЙСТВО ДЛЯ СОРТИРОВКИ ТВЕРДЫХ БЫТОВЫХ ОТХОДОВ
Creators: name: Уракбаев Жахонгир Бахтиёр угли, Ханкелов Тавбай Каршиевич, Мухамедова Нафиса Баходировна.
Publisher: name: Zenodo
Year: 2024

description: Аннотация: статья посвящена разработке устройства для сортировки твердых бытовых отходов, конструктивная особенность, которой позволяет сортировоать различные компоненты отходов. Легкая фракция отходов сортируются с помощью всасывающих рукавов, а тяжелые и упругие составляющие посредством баллистической сепарации.Конструктивная особенность баллистического сепаратора, позволяет сортировать отходы по плотности.

Abstract: The article is devoted to the development of a device for sorting solid household waste, a design feature that allows sorting various components of waste. The light fraction of waste is sorted using suction hoses, and the heavy and elastic components are sorted through ballistic separation. The design feature of the ballistic separator allows waste to be sorted by density.

Ключевые слова: твердые бытовые отходы, сортировка, дальность полета, автоматизированная сортировка.

Keywords: municipal solid waste, sorting, flight range, automated sorting.
Additional file 1 of Surface curvature-induced oriented assembly of sushi-like Janus therapeutic nanoplatform for combined chemodynamic therapy
Creators: name: Ma, Yanming
name: Liu, Minchao
name: Hou, Mengmeng
name: Kou, Yufang
name: Wang, Wenxing
name: Zhao, Tiancong
name: Li, Xiaomin
Publisher: name: figshare
Year: 2023
Subjects: Biophysics
Biochemistry
Space Science
Molecular Biology
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Supplementary Material 1
title: ADCO, Comptes du Petit-Cîteaux (1477-1491) (11 H 1179), f. 00320
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: comptes
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Comptes du Petit-Cîteaux (1477-1491), Archives départementales de la Côte-d'Or, (11 H 1179). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Comptes du Petit-Cîteaux (1477-1491), Archives départementales de la Côte-d'Or, (11 H 1179), f. 00320, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Reconciling EFT and hybrid calculations of the light MSSM Higgs-boson mass
Creators: name: Bahl, Henning
name: Heinemeyer, Sven
name: Hollik, Wolfgang
name: Weiglein, Georg
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Various methods are used in the literature for predicting the lightest CP-even Higgs boson mass in the Minimal Supersymmetric Standard Model (MSSM). Fixed-order diagrammatic calculations capture all effects at a given order and yield accurate results for scales of supersymmetric (SUSY) particles that are not separated too much from the weak scale. Effective field theory calculations allow a resummation of large logarithmic contributions up to all orders and therefore yield accurate results for a high SUSY scale. A hybrid approach, where both methods have been combined, is implemented in the computer code FeynHiggs. So far, however, at large scales sizeable differences have been observed between FeynHiggs and other pure EFT codes. In this work, the various approaches are analytically compared with each other in a simple scenario in which all SUSY mass scales are chosen to be equal to each other. Three main sources are identified that account for the major part of the observed differences. Firstly, it is shown that the scheme conversion of the input parameters that is commonly used for the comparison of fixed-order results is not adequate for the comparison of results containing a series of higher-order logarithms. Secondly, the treatment of higher-order terms arising from the determination of the Higgs propagator pole is addressed. Thirdly, the effect of different parametrizations in particular of the top Yukawa coupling in the non-logarithmic terms is investigated. Taking into account all of these effects, in the considered simple scenario very good agreement is found for scales above 1 TeV between the results obtained using the EFT approach and the hybrid approach of FeynHiggs.
description: 31 pages, 5 figures, matches version published in EPJC