cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Combinatorial SERS-MOFs platform for ultrasensitive biomarker detection
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Human biofluids contains hundreds of potential biomarkers relevant to early-stage cancer detection and diagnosis, including a subset of oncometabolites amongst the wider grouping of chemicals as volatile organic compounds (VOCs). Common techniques that provide multiplexed and accurate VOC detection, such as mass spectrometry, are bulky and cannot be integrated in future wearable devices for continuous monitoring. State-of-the-art wearable devices are largely based on electrochemical detection that greatly lack specificity, sensitivity, and ease. Besides, multiplexed detection is rare as specific systems need to be developed for each biomarker of interest. To build an effective wearable for multiplexed VOC detection, I propose the integration of two complementary technologies: (1) a multiplexed array of metal organic frameworks (MOFs), computationally designed to capture and enrich different subsets of tumor-associated VOCs, decorated with (2) metal nanostructures that enable ultrasensitive label-free readout via the surface enhanced Raman scattering (SERS) phenomena. Multiplexed detection of relevant metabolites will be used to build advanced cancer models by training on biofluid samples (e.g., plasma, saliva, sweat) collected from cancer patients in clinical care here at UC Davis.. This high-risk/high-reward approach is fundamentally different from competing approaches commonly employed in portable and wearable devices to monitor the concentration levels of a panel of biomarkers and will accelerate clinical diagnosis platforms for a wide range of cancers.
A response theory of topological insulators
Creators: name: Leung, Wing Fung
Publisher: name: No Publisher Supplied
Year: 2013

description: A time-reversal invariant topological insulator is defined by its topological magnetoelectric response that is robust against disorder.  The response formula, defined on a Brillouin torus,  defines a $mathbb{Z}72$ invariant and classifies the topological phase.  However, in the presence of disorder or the magnetic field, the notion of Brillouin torus is destroyed and the response formula is no longer well-defined.  This has been a challenging open problem, and it is essental in defining a topological insulator.  This thesis proposes a topological response theory that is free from this fundamental deficiency.  We derived the magnetoelectric response formula in position space for a generic three dimensional model under disorder and finite magnetic field.  For time-reversal invariant systems, we connected the result to the 2nd Chern number in Noncommutative Geometry.  We developed the noncommutative theory of Chern numbers and showed that the quantization of the magnetoelectric response is robust against disorder.  Numerical studies on serveral disodered topological models in 1D and 3D are presented.
The world of regionalism
Creators: name: Lewis, Jenna-Marie
Publisher: name: No Publisher Supplied
Year: 2013

description: In order to understand American regionalist aesthetics, we must look abroad.  This dissertation tells the story of nineteenth-century regionalism as a locally-specific textual expression of a transnational problem, specifically a problem of vision.  A critical preoccupation with the relays between region and nation in regionalist texts has diverted attention away from the transatlantic circulation of aesthetic styles within which American regionalism took shape, thereby producing a narrow view of the formal properties of regionalist texts.  By excavating these neglected aesthetic contexts, I show that nineteenth-century anxieties about the arbitrary and conditional nature of human perception—anxieties that both permeated various art forms and transcended national boundaries—are constitutive elements of regionalist literary form.  Regional sources constitute a particularly vibrant archive that speaks to how American literature of the late nineteenth century became a site for the circulation of a strikingly modern aesthetic grammar—one that regionalist writers not only drew upon but were actively engaged in developing.  Regionalist writers such as George Washington Cable, Washington Irving, Sarah Orne Jewett, Mary Murfree, Harriet Beecher Stowe, Mark Twain, and Constance Fenimore Woolson were deeply engaged with aesthetic preoccupations that transcended national concerns.  Regionalism therefore resonates with contemporaneous innovations in European fine arts—Impressionism, Paul Cézanne’s landscape paintings—as well as with avant-garde French performance art and the bohemian fin-de-siècle.  Attending to regionalism’s investment in the scientific, philosophical, and aesthetic explorations of the problem of vision enables a new way of categorizing the literary production of this transitional period of American literature.  By making local color writing recognizable as a visual problem, I draw together unfamiliar constellations of texts by means of their relationships to visual styles, visual technologies, and aesthetic movements.  Mark Twain’s mode of vision in his foreign travel writing aligns with the disintegrative visual experience of Impressionist representations; George Washington Cable’s magazine writing echoes French Orientalist painting and the gestural language of Parisian cabaret performers; and Mary Murfree’s landscape descriptions resonate with Paul Cézanne’s late landscapes.  These case studies add a new layer to our understanding of regionalism in a postnational context.
Inventaire du fonds Bastaire de littérature populaire et infantine [version 1]. Larousse
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024

description: Numérisation ICB CollEx-Persée AAP20212022
description: Les titres sont ceux donnés par Jean Bastaire. Les dates indiquées ont été établies depuis un courrier de Jean à Michel Bastaire qui lui demandait de dresser l'inventaire. Et la date de fin correspond à la donation et à la publication de Lectures englouties. Listes manuscrites de la collection établie par Jean Bastaire et Michel Bastaire ; Jean sous forme de livrets thématiques et feuilles volantes au format A5. Michel a consigné les titres dans un carnet bloc type Rhodia format A6.
description: Source: Fonds Bastaire Université Clermont Auvergne (Bas-G08_D096)
description: Relation: http://www.calames.abes.fr/pub/ms/_631139801_Bas-G08_D096
description: created: 1993/2008
A Conspiracy Argument for Optimality Theory: Emakhuwa Dialectology
Creators: name: Cassimjee, Farida
name: Kisseberth, Charles W.
Publisher: name: Penn Graduate Linguistics Society, University of Pennsylvania
Year: 1999

description: This paper [to be published in the proceedings of the University of Pennsylvania Colloquium in Linguistics for 1999] argues that while the “conspiracy argument” (originally developed in Kisseberth (19&0)) clearly supports the Optimality Theory model of phonology, it is not the case that conspiracies are just an attribute of the synchronic grammars of a single language. Conspiracy arguments can be replicated in a variety of phonological domains (acquisition, speech pathology, language change, dialectology). The present paper examines tonal phenomena in three dialects of Emakhuwa (a Bantu language spoken in northern Mozambique and neighboring regions of Tanzania and Malawi) and argues that rule-based generative phonology fails to capture the conspiratorial relationships obtaining in these dialects, wheras OT (in its Optimal Domains Theory implementation) succeeds in interpreting dialectal relationships as differences in the ranking of universal constraints.
Investigating the role of vascular mimicry in breast cancer metastasis.
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The proposed research will explore a new direction in my laboratory of the role of vascular mimicry in tumor initiating cells during breast cancer metastasis. Metastasis accounts for majority of breast cancer related deaths with women and therapeutic strategies that can prevent or reduce metastatic burden are urgently needed. It is now well established that breast tumor cells are heterogeneous and made up of transcriptionally distinct subsets with different tumor initiating potentials. In this model, minority populations of tumor cells referred to as metastasis initiating cells (MICs) display increased cellular plasticity reminiscent of immature stem-like cells in the normal mammary gland, and they have metastatic capabilities.
 Leaky vasculature and focal loss of CD31 in tumors has been linked to a phenomenon called vascular mimicry. In vascular mimicry, tumor cells form endothelial-like structures to provide nutrients and oxygen in a hypoxic environment. Increased vascular mimicry in tumors has been associated with immature tumor cells where it is reported that tumor initiating cells (TICs) under hypoxic conditions can differentiate to form endothelial-like structures. Moreover, vascular mimicry breast cancer is higher in more aggressive triple negative breast cancer subtype and is overall correlated with poor outcomes. However, the role of vascular mimicry during metastasis in human breast cancer and the mechanisms underlying this process remain unknown.
 Using single cell RNA-sequencing in patient tumors and computational tools that we developed, we recently identified a minority population of immature tumor cells that are THY1+/VEGFA+ and express the T-cell oncogene LMO2. Our preliminary data indicate that LMO2 is critical for metastasis in breast cancer. Surprisingly, we also find that LMO2+ breast cancer cells display vascular features, and co-associate with tumor endothelial cells. We hypothesize that tumor initiating cells in breast cancer utilize vascular mimicry to metastasize and LMO2 is a critical regulator of this process. Specifically, we will test 1. Whether vascular mimicry is required for metastasis in breast cancer? 2. Does expression LMO2 induce a vascular phenotype in breast cancer cells? 2. Does LMO2 regulate vascular leakiness and vascular mimicry in PDX models in vivo to metastasize?
Rhyacophila fasciata Hagen 1859
Creators: name: Valladolid, Maria
name: Waringer, Johann
name: Arauzo, Mercedes
name: Chvojka, Pavel
name: Dorda, Beatriz A.
name: Komzák, Petr
name: Lodovici, Omar
name: Rey, Isabel
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Rhyacophilidae
Rhyacophila
Rhyacophila fasciata

description: Rhyacophila fasciata Hagen 1859
This species was studied and redescribed in previous papers by Valladolid et al. (2020, 2021), including the morphology of larva, pupa, male and female; genetics; ecology; and distribution in the European countries. A dataset of specimens studied is also available (Valladolid et al. 2023)
description: Published as part of Valladolid, Maria, Waringer, Johann, Arauzo, Mercedes, Chvojka, Pavel, Dorda, Beatriz A., Komzák, Petr, Lodovici, Omar & Rey, Isabel, 2023, The Rhyacophila fasciata Species Complex (Trichoptera: Rhyacophilidae) in Central Europe with description of a new species, Rhyacophila loeffleri Valladolid & Waringer, n. sp., based on morphological, genetic and ecological evidence., pp. 451-482 in Zootaxa 5325 (4) on page 461, DOI: 10.11646/zootaxa.5325.4.1, http://zenodo.org/record/8243592
Markedness and the Development of Prosodic Structure
Creators: name: Demuth, Katherine
Publisher: name: GLSA (Graduate Linguistic Student Association), Dept. of Linguistics, University of Massachusetts
Year: 1995

description: It has long been noted that children's early words are truncated in form, and that those forms show a certain degree of variability in shape. In this paper I show how the prosodic development of children's early words can be naturally accounted for in terms of prosodic constraints on output form. Critically, I assume that children's segmental representations of lexical items are full from the beginning, but that early emergence of unmarked prosodic structures (e.g. Core Syllables and Minimal Words), combined with the low initial ranking of PARSE conspire to yield early word structures that differ from adult target forms in a principled manner. I conclude by showing how a given constraint ranking can provide an account of variability in form at a given point in time, whereas a shift in constraint ranking is needed to account for development over time. In so doing, I demonstrate how the process of language acquisition can be thought of as an optimization problem, and how OT might be adapted to provide for a theory of both competence and performance.
Housing assistance planning 19&5
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1975

description: In mid-November of 19&4 the City of Paterson established a community Development Task Force whose primary function was to prepare a Community Development Block Grant Program for submission to the citizenry and approval by City Council, in order to effectively employ Community Development Funds to be received by the City upon acceptance of the Program and Application by the Department of Housing and Urban Development.This report is a direct result of the intensive work effort conducted by the Staff of the Division of Planning and Zoning from the initial activation of the project, to the time when all data that had been collected and identified, all peveloper proposals, and the housing rehabilitation program proposals were made available to the Planning and Development Consulting firm, Abeles, Schwartz & Associates.
Investigating G-quadruplex induced instability in B cell lymphomagenesis
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Genome instability arising during DNA replication strongly contributes to the formation of oncogenic mutations and chromosome rearrangements, including B cell lymphomas. Conflicts with the transcriptional machinery are a potent source of replication stress in proliferating cells. In response to antigen stimulation, B cells undergo a massive burst of transcription and proliferation. Recently we identified a set of loci that experience recurrent transcription-replication interactions (TRIs) in activated primary B cells. TRIs accumulate marks of replication stress, colocalize with double-strand DNA breaks, are enriched for deletions, and accumulate mutations in tumors. Together, these results suggest replication-associated damage accumulates at TRI loci in rapidly proliferating B cells. Over 95% of TRI regions are capable of forming G-quadruplex (G4) structures—secondary DNA structures formed in guanine-rich DNA that organize into a planar tetrad. G4s are stable and can impede replication fork progression, inducing DNA damage. Here we propose to investigate the causal relationship of G4 stabilization on genome instability at TRIs. Of particular interest, mutations involving two TRI loci—the oncogenes Bmi1 and Bcl2—are associated with hematopoietic malignancy and chemoresistance. Bmi1 plays a critical role in stem cell renewal and multipotency while Bcl2 regulates apoptosis-mediated cell death. Using the G4 stabilizing drug pyridostatin, we will investigate if TRIs exhibit a higher rate of DNA damage and mutation in WT and Brca1-deficient primary cells. Brca1 is a tumor suppressor involved in replication fork stabilization and potentially protects TRI loci from accumulating DNA damage. To investigate the impact of G4 stabilization at TRIs, we will define the frequency of pyridostatin-induced DNA damage at two TRI loci—Bmi1 and Bcl2—and two negative controls in WT and Brca1-deficient cells by analyzing unrepaired DNA breaks by fluorescent in situ hybridization (FISH) and micronucleus formation by microscopy. At the same time, we will characterize proliferative index, cell cycle progression and viability. Characterizing how endogenous sources drive the formation of oncogenic mutations and rearrangements is critical to understanding how lymphoid cancers arise and will provide new targets for personalized treatments and cancer prevention.
Chaetorellia Hendel
Creators: name: El-Hawagry, Magdi S.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Tephritidae
Chaetorellia

description: Genus CHAETORELLIA Hendel
Chaetorellia Hendel, 1927a: 121. Type species: Tephrytis jaceae Robineau-Desvoidy, 1830, original designation.
description: Published as part of El-Hawagry, Magdi S., 2017, Catalogue of Egyptian Tephritoidea (Diptera: Schizophora: Acalyptratae), pp. 151-190 in Zootaxa 4299 (2) on page 176, DOI: 10.11646/zootaxa.4299.2.1, http://zenodo.org/record/843233
America noviter reperta, la malintesa linea rossa e altre pareidolie
Creators: name: Salvador, Silvano
Publisher: name: Knowledge Commons
Year: 2025
Subjects: subject: Cartography

description: I will resume and conclude a discussion on the red lines that are seen in some parts of the Tabula Peutingeriana. With the addition of more pareidolies and some cartographic insights about America
Hisonotus thayeri Martins & Langeani 2016
Creators: name: Langeani, Francisco
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Siluriformes
Loricariidae
Hisonotus
Hisonotus thayeri

description: Hisonotus thayeri Martins & Langeani (2016).
Paratypes: 1 lot, 8 specimens; DZSJRP 20157 (4 c&s), 13.4¯ 32.6 mm SL, Muniz Freire, stream affluent to rio Norte, Minas Gerais, Brazil, 20°22’31”S, 41°24’41”W, cols. R.L. Teixeira & G.I Almeida, 8 October 2001.
description: Published as part of Langeani, Francisco, 2017, Annotated catalog of the type specimens deposited at the fish collection of the " Universidade Estadual Paulista, Câmpus de São José do Rio Preto ", São Paulo, Brazil (DZSJRP), pp. 435-460 in Zootaxa 4319 (3) on page 444, DOI: 10.11646/zootaxa.4319.3.2, http://zenodo.org/record/890303
Recombination hotspot activity in Drosophila melanogaster
Creators: name: Mehdi, Mahrose
Publisher: name: No Publisher Supplied
Year: 2013

description: Sexual reproduction depends on the success of faithful chromosome transmission during meiosis to yield viable gametes. Crucial to proper meiosis is the process of recombination between paternal and maternal chromosomes which ensures normal homologous chromosome segregation. Errors in number and location of the recombination events are known to be one of the leading causes of nondisjunction and aneuploidy. Recombination events tend to cluster in certain regions of the genome where the frequency of recombination is high compared to the average recombination rate. These regions are called recombination hotspots. The identification of these hotspots will bring us closer to understanding the etiology of nondisjunction. We used transposon insertion at defined sites to test for recombination hotspots in Drosophila melanogaster. The first method employs two transposable element bearing fly strains that have the insertion at sites flanking the proposed hotspot. The number of recombination events in the interval between the two transposon insertion sites is used to detect hotspots. The second strategy is to generate a double strand break (DSB) by mobilizing the excision of the transposon from a precise location. By monitoring the outcomes of DSB repair event at these loci, sites that have a higher recombination rates can be detected. Unfortunately, both methods did not reveal hotspot activity.  Studies in yeast and mammals have uncovered a few genes that have a large effect on the distribution and pattern of recombination events. In Saccharomyces cerevisiae, Set1 complex (also known as COMPASS complex) has been shown to decreases DSB frequencies at > 80% of DSB sites genome-wide and cause changes in their localization. We want to know if Set1 complex plays a major role in controlling DSB sites in Drosophila Melanogaster also. RNAi mediated knockdowns of subunits of the Set1 complex are used to investigate if these flies show a reduction of DSBs. Although Set1 complex knockdowns did not have a significant effect on the DSBs, they may play a role in the repair of DSBs and oocyte development.
Evaluation of ketogenic diet strategies for pancreatic cancer-associated cachexia
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Pancreatic cancer (PC) is a deadly disease, with limited effective treatments. At the time of diagnosis, around 80% of PC patients suffer from cachexia, a condition that involves progressive weight loss, nutritional deterioration and loss of muscle mass. Therefore, new strategies to improve patients’ survival and quality of life are urgently needed. Our proposed research will study the role of a ketogenic diet (KD) in PC. In particular, we want to know if this particular diet can improve the quality of life and help prevent cachexia. KDs are diets characterized by having a high fat content and almost no carbohydrates (sugars). In preliminary studies, we observed that in mice that have PC, the mice fed a strict KD had significantly improved motor function compared to mice fed a control diet. In addition, the mass of the thigh muscle was higher in mice fed a strict KD, compared to mice that consumed a control diet. These preliminary studies strongly indicate that a KD might be a beneficial dietary treatment for PC-induced cachexia. However, exactly how this happens and whether other KD strategies are useful for PC-associated cachexia remains unknown. Based on the above, in this proposal, we plan to investigate how a KD prevents cachexia progression in a clinically relevant PC mouse model (KPC mice). We will feed KPC mice with a KD along with standard treatment, and evaluate the effect on tumor growth and on indicators of cachexia. We will investigate markers of muscle strength and identify cellular mechanisms that may explain the observed effect. In addition, since strict diets are difficult to maintain throughout cancer treatment, we propose to test if intermittent feeding of a KD (for example feeding a KD for some days a week, instead of every single day), can achieve similar effects as observed with the strict KD. The successful completion of these studies could lead to new treatment strategies to mitigate cancer cachexia.
Application of fragment screening by X-ray crystallography for the identification of novel chemical scaffolds targeting viral proteins of HIV and influenza
Creators: name: Patel, Disha
Publisher: name: No Publisher Supplied
Year: 2013

description: Fragment-based drug discovery (FBDD) is a relatively new approach for discovery of small molecule ligands for subsequent lead development. Here, libraries of relatively small molecules or fragments are screened against a target protein to identify hits with relatively weak binding affinity. Several approaches, which include fragment linking, merging, and expansion, can then be utilized to develop these hits into lead candidates.     The intrinsically weak binding affinity of fragments requires screening techniques capable of detecting very weak non-covalent interactions with the protein. Biophysical methods, such as nuclear magnetic resonance (NMR), X-ray crystallography, and surface plasmon resonance (SPR), have been traditionally used for FBDD. X-ray crystallography, in particular, has been underappreciated due to major drawbacks associated with low throughput and labor associated. However, advancements in rapid, automated data collection has improved the throughput and reduced the labor associated with this approach.     This thesis reports the development of a high throughput screening method using X-ray crystallography and its successful application as a primary screening tool to identify new compounds for lead development against viral drug targets. Specifically, screening was conducted against HIV-1 reverse transcriptase (RT), the catalytic core domain of HIV-1 integrase (IN CCD), and the cap-snatching endonuclease domain of influenza A. Screening revealed fragment binding to promising, druggable allosteric sites within HIV-1 RT and IN CDD. The availability of a three dimensional structure proved to be highly advantageous as it allowed for structure-based drug design (SBDD) to be pursued. Using this approach, a fragment hit identified to bind to the endonuclease domain of influenza was developed into a new class of endonuclease inhibitors with antiviral activity. This thesis not only details the results from each of the screening campaign but also highlights many key advantages of crystallographic fragment screening.
Hypostomus careopinnatus Martins, Marinho, Langeani & Serra 2012
Creators: name: Langeani, Francisco
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Siluriformes
Loricariidae
Hypostomus
Hypostomus careopinnatus

description: Hypostomus careopinnatus Martins, Marinho, Langeani & Serra (2012).
Holotype: DZSJRP 12231, 57.9 mm SL, tributary to rio Ariranha, rio Taquari drainage, rio Paraguay basin, Alto Araguaia, Mato Grosso, Brazil, 17°18’37”S, 53°32’22”W, cols. F. Langeani, J.P. Serra, M.M.F. Marinho, A. Manzale, 11 August 2009 (Fig. 8).
Paratypes: 2 lots, 116 specimens; DZSJRP 12447, 60, 70 in the original description, 21.2–57.0 mm SL, collected with the holotype; and DZSJRP 12611, 56 (tissue samples of 5 specimens), 16.9–59.1 mm SL, same locality as holotype, cols. F. Langeani, J.P. Serra, M.M. F. Marinho, F.O. Martins, 3 June 2010.
description: Published as part of Langeani, Francisco, 2017, Annotated catalog of the type specimens deposited at the fish collection of the " Universidade Estadual Paulista, Câmpus de São José do Rio Preto ", São Paulo, Brazil (DZSJRP), pp. 435-460 in Zootaxa 4319 (3) on pages 444-446, DOI: 10.11646/zootaxa.4319.3.2, http://zenodo.org/record/890303
Supporting African American Women During Treatment and Survivorship Through Peer Navigation
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The ultimate goal of our community-university partnership is to widely disseminate an effective peer navigation program for Black/African American (referred to as Black hereafter) women going through breast cancer treatment and during survivorship throughout California. This study was developed by a strong community-university partnership between Black Ladies Advocating for Cancer Care (BLACC), Charlotte Maxwell Clinic and the Stanford Medicine Office of Community Engagement based on principles of community-based participatory research. While Black women are just as likely to develop breast cancer as non-Hispanic white women, they are more likely to be diagnosed at a young age, with more aggressive and severe forms of breast cancer, and to die of breast cancer compared to all other women. Black women going through treatment and survivorship report worse quality of life compared to their peers. Peer navigation programs have been shown to improve breast cancer outcomes and quality of life among Black women. Through a pilot award, BLACC and Stanford strengthened their partnership and completed 19 qualitative storytelling sessions with Black breast cancer survivors and caregivers, as well as 6 key informant interviews to inform the peer navigation program. The logical next stage of the partnership’s research is to further refine the peer navigation program and conduct a pilot test evaluating the acceptability and preliminary effectiveness. The formative research and engagement with the Community Advisory Board (CAB) identified quality of life as the primary outcome of importance to Black women. In addition, we will collect preliminary data to inform implementation, dissemination, and sustainability according to the RE-AIM (Reach Effectiveness Adoption Implementation and Maintenance) framework and using the Program Sustainability Assessment Tool. The CAB we developed during the pilot award will continue to have an integral role in all phases of the proposed research. In addition, we will continue to strengthen and evaluate our community-university partnership. Successful completion of these aims will facilitate future widespread dissemination of a peer navigation developed by and for Black/African American women going through breast cancer treatment and survivorship.
Localized translation regulation in a cancer metastasis model
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Metastasis is the main cause of death among cancer patients. Protein synthesis is required to support the high anabolic demand of invasive cells and has emerged as a driver of cancer progression and metastasis. Mesenchymal cell migration, one common mechanism of cell migration in cancer, requires localized translation at the leading edge of the cell. Protrusions are enriched in ribosomes, translation initiation and elongation factors. Yet, how this machinery is recruited and locally regulated remains elusive. With this Cancer Research Coordinating Committee grant we will test two hypotheses:

 1) We hypothesize that the receptor of activated kinase C (RACK1) anchors ribosomes near the cell membrane via interactions with adhesion complexes. RACK1 is a ribosome-associated protein. RACK1 is also a structural component of early and mature adhesion complexes, which are important for cell migration. We will test the importance of RACK1 interactions with these complexes for mesenchymal cell migration.

 2) We hypothesize that the metabotropic glutamate receptor 1 (mGluR1) - eukaryotic elongation factor 2 kinase (eEF2K) interaction is important for regulating cancer cell migration by locally affecting translation elongation. Several cancers express mGluR1, a protein typically only expressed in neurons. The intracellular domain of mGluR1 interacts with and regulates eEF2K, the main regulator of translation elongation. Both, eEF2K and mGluR1 upregulation is associated with a poor prognosis, and invasive and metastatic tumors. We will test the importance of the mGluR1 - eEF2K interaction for mesenchymal cell migration.

 We will modify an established in vitro migration assay using a human breast cancer cell line that expresses mGluR1, eEF2K, and RACK1. We will leverage overexpression of protein fragments to elicit dominant-negative effects by disrupting specific molecular interactions.

 Elongation inhibitors have already emerged as a cancer therapeutic. However, molecules that broadly target protein synthesis are associated with severe side-effects due to the central role of the ribosome in all cells. More targeted approaches are needed. Results from this research will reveal novel therapeutic targets. We further expect that results from this research provide the foundation for further mechanistic studies and allow us to successfully apply for federal funding.
Targeting LRP1 to Reduce the Incidence of Paclitaxel Induced Painful Peripheral Neuropathy
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Chemotherapy induced peripheral neuropathy (CIPN) is the most common neurological complication of chemotherapy treatment for cancer patients. Patients with CIPN have sensory nerve impairment accompanied by pain that frequently results in dose reductions and decreases in treatment adherence. Although precision medicine is in development, most cancer patients still receive chemotherapies that jeopardize nerve health. There is a great unmet medical need to identify novel targets and treatments for CIPN associated pain. Paclitaxel is a widely used and highly effective chemotherapy agent that induces painful CIPN. Paclitaxel activates innate immunity including increased Toll-like receptors (TLR) 4 in sensory neurons that have been implicated in persistent pain states. Recent studies have identified the low-density lipoprotein receptor related protein (LRP1), as a receptor highly involved in regulating innate immunity and reducing neuroinflammation.Using innovative activators of LRP1, enzymatically inactive-tissue plasminogen activator (EI-tPA) and a peptide, SP16, derived from a-1-Antitrypsin (AAT) we demonstrated that activation of LRP1 alleviated pain related behaviors in three distinct pre-clinical pain models (acute, inflammatory and neuropathic). In the neuropathic pain model, LRP1 activation reduced recruitment of inflammatory cells and of TLR4 levels.

 This project will be conducted by an established investigator, with expertise in neuropathic pain and LRP1 biology, that is initiating new research in cancer related pain. She has recruited an oncologist, Dr. Jenn Matro, from UCSD Moore’s Cancer Center to participate in this preclinical work. The team will investigate effects of LRP1 activators, EI-tPA and SP16 in paclitaxel induced painful neuropathy (PIPN). First, we examine effects of LRP1 activation in pain-related behaviors in an established mouse model of PIPN. We identify dosing paradigms as both adjuvant therapy and in established pain. Next, we examine changes in innate immunity and neuroinflammation regulated by LRP1 activation in dorsal root ganglia during PIPN. Recently, SP16 was safely dosed in a Phase I clinical trial enhancing the potential translational nature of this proposal. Moreover, LRP1 activators do not appear to support breast or oral cancer tumor growth. These studies may identify a novel treatment for patients with PIPN.
The unity and scope of knowledge
Creators: name: Pavese, Carlotta
Publisher: name: No Publisher Supplied
Year: 2013

description: Orthodoxy has it that knowledge is bifurcated between di erent kinds of states and  in particular that there are species of knowledge that cannot be reduced to knowledge  of truths. Moreover, it is commonly alleged that knowledge of truths alone falls short  of explaining a distinctive kind of human capacity: the human capacity for skillful  actions. This dissertation challenges both these orthodoxies.    In the fi rst chapter, "Know how and Gradability," I defend the unity of knowledge  against the single most powerful and thus far unanswered argument against it, what  I call "The argument from gradability." According to this argument from gradability,  due to Gilbert Ryle (1949) in The Concept of Mind, know how and propositional  knowledge cannot be the same state, because the  first comes in degrees, whereas the  latter is absolute. In this chapter, I argue that the Rylean argument from gradability  to dualism fails, as it moves too quickly from the surface form of ascriptions of know  how to conclusions about the state that is ascribed by means of those ascriptions.    According to Intellectualism about know how, knowing how to do something is a  matter of possessing a piece of propositional knowledge. Intellectualists about know  how routinely appeal to practical modes of presentation in characterizing the relevant  kind of propositional knowledge. But we are never told much about the nature of  these modes of presentation. In Chapter II, I propose a positive view of practical modes of presentation.  In the fi nal chapter "Skills as knowledge," I argue that propositional knowledge  explains the human capacity for skillful and intelligent actions. In the fi rst part of  the chapter, by elaborating on the picture of content developed in Chapter II, I argue  that having a skill to   for a task   is a matter of knowing a particular kind of answer  to the question "How to F" . In the second part of the chapter, I propose a direct  argument for thinking of skills as propositional knowledge states.
Hypostomus yaku Martins, Langeani & Zawadzki 2014
Creators: name: Langeani, Francisco
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Siluriformes
Loricariidae
Hypostomus
Hypostomus yaku

description: Hypostomus yaku Martins, Langeani & Zawadzki (2014).
Holotype: DZSJRP 15735, 70.8 mm SL, tributary to rio Piracanjuba, near water treatment station, rio Quente basin, rio Paranaíba drainage, Goiás, Brazil, el. 618 m, 17°46’32”S, 48°45’56”W, cols. F. Langeani, F.R. Carvalho & F.O. Martins, 7 Mar 2012 (Fig. 9).
Paratypes: 3 lots, 94 specimens; DZSJRP 15743, 3, 30.2–48.7 mm SL, rio Quente near the bridge, at Rio Quente Resort, in the road to Pousada Hotel, Goiás, Brazil, el. 596 m, 17°46’28”S, 48°45’13”W, cols. F. Langeani, F.R. Carvalho, F.O. Martins, 8 March 2012; DZSJRP 15747, 12, 12.4–59.7 mm SL, rio Quente, under the bridge at Esplanada district, Goiás, Brazil, el. 622 m, 17°46’22”S, 48°45’23”W, col. F. Langeani, F.R. Carvalho & F.O. Martins, 8 March 2012; and DZSJRP 16421, 79 (2 c&s, tissue sample of 7 specimens), 72 in the original description, 10.7–60.7 mm SL, collected with the holotype.
Remarks: The discrepancy between the number of specimens (paratypes) herein listed and those mentioned in the original description may be due to a counting error in the original description.
description: Published as part of Langeani, Francisco, 2017, Annotated catalog of the type specimens deposited at the fish collection of the " Universidade Estadual Paulista, Câmpus de São José do Rio Preto ", São Paulo, Brazil (DZSJRP), pp. 435-460 in Zootaxa 4319 (3) on pages 447-448, DOI: 10.11646/zootaxa.4319.3.2, http://zenodo.org/record/890303
Rhaphium eburnea
Creators: name: Grootaert, Patrick
name: Taylor, Christopher
name: Guénard, Benoit
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Dolichopodidae
Rhaphium
Rhaphium eburnea

description: Rhaphium eburnea (Parent, 1926)
Fig. 8
Porphyrops eburnea Parent, 1926: 139 (type locality: Zi-Ka-Wei, Shanghai, China).
Diagnosis
Larger species (5 mm). Male: legs yellow except for all coxae black, fore femur dorsally black, tip of hind femur, base and tip of hind tibia and apical 2 tarsomeres of fore and mid leg and all hind tarsomeres black. Postpedicel elongate triangular, twice as long as wide, arista 3 × as long as postpedicel. Fore coxa with long bristles, near base with white bristles, on apical half white bristles mixed with black bristles. Tip of mid coxa with a number of adhering bristles forming a thorn.
Type material
Syntypes CHINA – Shanghai • 1 ♂, 2 ♀♀; Zi-Ka-Wei; 17 May 2017; MNHN • 1 ♀; Kao Gkiao; 23 Oct. 2017; MNHN [as communicated by Mr Emmanuel Delfosse, Paris].
description: Published as part of Grootaert, Patrick, Taylor, Christopher & Guénard, Benoit, 2019, Three new species of Rhaphium Meigen, 1803 from mangroves in Hong Kong (Diptera: Dolichopodidae: Rhaphiinae), pp. 1-21 in European Journal of Taxonomy 540 on page 17, DOI: 10.5852/ejt.2019.540, http://zenodo.org/record/3357392
The world as emergent from pure entropy
Creators: name: Harvey-Tremblay, Alexandre
Publisher: name: Figshare
Year: 2017
Subjects: subject: 20304 Thermodynamics and Statistical Physics
subject: FOS: Mechanical engineering
subject: Thermodynamics

description: We propose a framework to understand the universe in which an ensemble of theorems rather than a set of axioms define the theory. We prove meta-logically that the theorems of the ensemble must have *feasible* proofs and must recover *universality*. The ensemble is axiomatized when it is constructed as a partition function, in which case its axioms are, up to an error rate, the bits of Omega (the halting probability of a prefix-free universal Turing machine).
As a consequence of the axiomatization, the ensemble adopts the mathematical structure of an ensemble of statistical physics. It is from this context that the laws of physics are derived. It is shown that the Lagrange multipliers of the partition function are the fundamental Planck units and that the background, a thermal spacetime, emerges as a consequence of the limits applicable to the conjugate pairs. The background obeys the relations of special and general relativity, dark energy, the arrow of time, the Schrödinger equation, the Dirac equation and it embeds the holographic principle. The laws of physics are emergent from the computational connection between axioms and theorems.
The framework is so fundamental that informational-equivalents to length, time and mass (assumed as axioms in most physical theories) are here formally derivable. It can prove that no alternative framework can contain less bits of axioms than it contains (hence it is necessarily the simplest theory). Furthermore, it can prove that, for all worlds amenable to this framework, the laws of physics will be the same (hence there can be no alternatives).
Thus, the framework is a candidate for a final theory.
Chaetorellia carthami Stackelberg 1929
Creators: name: El-Hawagry, Magdi S.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Tephritidae
Chaetorellia
Chaetorellia carthami

description: Chaetorellia carthami Stackelberg, 1929
Chaetorellia carthami Stackelberg, 1929: 225. Holotype. Uzbekistan (Tashkent distr.: near Jaroslavskoe) (ZISP). Distribution. PA: Egypt, Southern Europe, Turkistan, Israel, West Asia. Egyptian localities. Sinai: Sinai Mts., Southwestern Sinai.
Host plants. Safflower (Carthamus tinctorius L.) and starthistles (Centaurea sp.). Dates of collection. February to October.
description: Published as part of El-Hawagry, Magdi S., 2017, Catalogue of Egyptian Tephritoidea (Diptera: Schizophora: Acalyptratae), pp. 151-190 in Zootaxa 4299 (2) on page 176, DOI: 10.11646/zootaxa.4299.2.1, http://zenodo.org/record/843233
The public library in an immigrant neighborhood
Creators: name: Pozzi, Ellen Marie
Publisher: name: No Publisher Supplied
Year: 2013

description: This historical study of Italian immigrants’ information ecologies addresses the current lack of research on immigrants and libraries. The objective of this research is to develop a textured understanding of the information ecology of Italian immigrants, the exemplary group chosen for this study. The study is situated in Newark which was the site of immigrant settlement and vibrant immigrant information circuits during the last decade of the nineteenth and the first two decades of the twentieth century; a time when the reforms of the Progressive Era, an influx of immigrants, and the effects of urbanization intersected with a growing public library movement. A new conceptualization labeled the Information Neighborhood was developed in this dissertation as a framework to capture the rich information networks within Italian enclaves at the turn of the twentieth century. This framework draws on the work of Robert Darnton’s communication circuits and provides a structure for the descriptions of Italian information resources within their information ecologies and for the exploration of communication media and modes within immigrants’ enclaves. This research and the concept of the Information Neighborhood was informed by Michel de Certeau’s theories of appropriation and of strategies and tactics. Subaltern Studies was employed as a novel approach to the investigation of library history. Subaltern Studies Group’s metatheoretical approach to history from the perspective of marginalized groups positions immigrants as subjects of their own histories. Subaltern Studies also provided a methodology for reading institutional and official sources against the grain to document Italian immigrant print culture and the library’s practices. This subaltern reading revealed tensions in the discourse over Americanization and reading in foreign languages. It established immigrants as actively demanding foreign language material in the library. Both immigrant and librarian discourses revealed cross-cultural and cross-class tensions as well as power imbalances. The research also revealed that the acquisition of Italian language material was positioned within the discourse of the “fiction question” that championed high culture over popular culture. This study advances the understanding of the complex relationship between immigrants and public libraries, privileges Italian immigrant perspectives, and provides a deep examination of their holistic information worlds and practices.
South Asians and the problem of the color line
Creators: name: Ramsamy, Kavitha
Publisher: name: No Publisher Supplied
Year: 2013

description: Modern migration has resulted in the unsettlement of the identities of migrants who live, work, and struggle – for rights, opportunities, and recognition – with other populations in new national contexts. This dissertation considers the identities of South Asian migrants to South Africa and the United States, two nation-states that have been involved deeply in the creation of ideologies of race as well as regimes of racial practice.  Focusing on the late 19th century to the late 20th century, I show how South Asian migrants were historically positioned within the racial hierarchies of these two societies, and how they constructed their identities in relation to racial others. I analyze contact, conflict, and cooperation between South Asians and other racial subjects in a comparative, cross-national perspective, and consider the transnational exchange of ideas that led to particular strategies of resistance. I argue that South Asian struggles in South Africa and the United States for rights and recognition resulted in a transnational articulation of modern social movements for national liberation, civil rights, and democracy.
All institutionalization is local
Creators: name: Levi-Sanchez, Suzanne
Publisher: name: No Publisher Supplied
Year: 2013

description: In my dissertation I posit a simple question: What is the importance of local leaders and local identity groups to the stability of a state's border and ultimately, the stability of the state? In order to answer this question I conducted ethnographic fieldwork in the borderlands of Afghan/Tajik Badakhshan.  As part of my fieldwork, I lived with families, worked with NGOs and IGOs and studied local foundational narratives.  As a framework for my analysis, I define three main concepts:  borders, institutions, and identity.  The interaction of these concepts with the data collected during my fieldwork led me to three main findings.   First, when the state increases authority through formalization of institutional infrastructure at the border, then local leaders will be marginalized and the local population will be alienated from the state and this will decrease overall stability. Moreover, national identity will weaken while (some) local identities will strengthen.  Second, if the state works to monopolize power at the border, the stability in the border region decreases as local groups assert alternative forms of identity as a form of silent protest.  Third, if local leaders and organizations are given semi-autonomy in coordination with state border forces, then the borderlands will be more stable and national identity will be more broadly accepted.