Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women
Creators: name: Steinthorsdottir, Valgerdur
name: McGinnis, Ralph
name: Williams, Nicholas O.
name: Stefansdottir, Lilja
name: Thorleifsson, Gudmar
name: Shooter, Scott
name: Fadista, João
name: Sigurdsson, Jon K.
name: Auro, Kirsi M.
name: Berezina, Galina
name: Borges, Maria-Carolina
name: Bumpstead, Suzannah
name: Bybjerg-Grauholm, Jonas
name: Colgiu, Irina
name: Dolby, Vivien A.
name: Dudbridge, Frank
name: Engel, Stephanie M.
name: Franklin, Christopher S.
name: Frigge, Michael L.
name: Frisbaek, Yr
name: Geirsson, Reynir T.
name: Geller, Frank
name: Gretarsdottir, Solveig
name: Gudbjartsson, Daniel F.
name: Harmon, Quaker
name: Hougaard, David Michael
name: Hegay, Tatyana
name: Helgadottir, Anna
name: Hjartardottir, Sigrun
name: Jääskeläinen, Tiina
name: Johannsdottir, Hrefna
name: Jonsdottir, Ingileif
name: Juliusdottir, Thorhildur
name: Kalsheker, Noor
name: Kasimov, Abdumadjit
name: Kemp, John P.
name: Klungsøyr, Kari
name: Lee, Wai K.
name: Melbye, Mads
name: Miedzybrodska, Zosia
name: Moffett, Ashley
name: Najmutdinova, Dilbar
name: Nishanova, Firuza
name: Olafsdottir, Thorunn
name: Perola, Markus
name: Poston, Lucilla
name: Prescott, Gordon
name: Saevarsdottir, Saedis
name: Salimbayeva, Damilya
name: Scaife, Paula Juliet
name: Skotte, Line
name: Staines-Urias, Eleonora
name: Stefansson, Olafur A.
name: Sørensen, Karina Meden
name: Thomsen, Liv Cecilie Vestrheim
name: Tragante, Vinicius
name: Trogstad, Lill
name: Simpson, Nigel A. B.
name: Aripova, Tamara
name: Casas, Juan P.
name: Thorsteinsdottir, Unnur
name: Iversen, Ann-Charlotte
name: Feenstra, Bjarke
name: Lawlor, Deborah A.
name: Boyd, Heather Allison
name: Magnus, Per
name: Zakhidova, Nodira
name: Svyatova, Gulnara
name: Stefansson, Kari
name: Laivuori, Hannele
name: Heinonen, Seppo
name: Kajantie, Eero
name: Kere, Juha
name: Kivinen, Katja
name: Pouta, Anneli
name: Morgan, Linda
name: Pipkin, Fiona Broughton
name: Walker, James J.
name: Macphail, Sheila
name: Kilby, Mark
name: Habiba, Marwan
name: Williamson, Catherine
name: O’Shaughnessy, Kevin
name: O’Brien, Shaughn
name: Cameron, Alan
name: Redman, Christopher W. G.
name: Farrall, Martin
name: Caulfield, Mark
name: Dominiczak, Anna F.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Article
/631/208/205/2138
/692/699/75/243
/692/699/2732
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/45/43
article

description: Funder: EC | EC Seventh Framework Programm | FP7 Health (FP7-HEALTH - Specific Programme "Cooperation": Health); doi: https://doi.org/10.13039/100011272; Grant(s): 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540, 282540
description: Funder: EC | EC Seventh Framework Programm | FP7 Health (FP7-HEALTH - Specific Programme "Cooperation": Health)
description: Funder: U.S. Department of Health &amp; Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
description: Abstract: Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.