cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Anatomy-aware and acquisition-agnostic joint registration with SynthMorph
Creators: name: Hoffmann, Malte
name: Hoopes, Andrew
name: Greve, Douglas N.
name: Fischl, Bruce
name: Dalca, Adrian V.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Image and Video Processing (eess.IV)
subject: Artificial Intelligence (cs.AI)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Machine Learning (cs.LG)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: Affine image registration is a cornerstone of medical image analysis. While classical algorithms can achieve excellent accuracy, they solve a time-consuming optimization for every image pair. Deep-learning (DL) methods learn a function that maps an image pair to an output transform. Evaluating the function is fast, but capturing large transforms can be challenging, and networks tend to struggle if a test-image characteristic shifts from the training domain, such as resolution. Most affine methods are agnostic to the anatomy the user wishes to align, meaning the registration will be inaccurate if algorithms consider all structures in the image. We address these shortcomings with SynthMorph, a fast, symmetric, diffeomorphic, and easy-to-use DL tool for joint affine-deformable registration of any brain image without preprocessing. First, we leverage a strategy that trains networks with widely varying images synthesized from label maps, yielding robust performance for image types unseen at training. Second, we optimize the spatial overlap of select anatomical labels. This enables networks to distinguish anatomy of interest from irrelevant structures, removing the need for preprocessing that excludes content that may impinge on anatomy-specific registration. Third, we combine the affine model with a deformable hypernetwork that lets users choose the optimal deformation-field regularity for their specific data, at registration time, in a fraction of the time required by classical methods. We analyze how competing architectures learn affine transforms and compare state-of-the-art registration tools across an extremely diverse set of neuroimaging data, aiming to truly capture the behavior of methods in the real world. SynthMorph demonstrates high accuracy and is available at https://w3id.org/synthmorph, as a single complete end-to-end solution for registration of brain MRI.
description: 33 pages, 19 figures, 4 tables, affine registration, deformable registration, deep learning, hypernetwork, domain shift, neuroimaging, final published version
MINERVE 2014 cruise,L'Astrolabe R/V
Creators: name: TOURATIER Franck
name: GOYET Catherine
Publisher: name: Sismer
Year: 2014

description: Estimation de la tendance de l'évolution du système CO2 dans l'océan austral. Le programme MINERVE (Mesures à l'Interface Eau- aiR de la Variabilité des Echanges de CO2), qui s'appuie sur des campagnes océanographiques entre Hobart (Australie) et la terre Adélie (Base française en Antarctique), a pour objectif d'observer et de comprendre les variabilités saisonnières de la pression partielle de CO2 (pCO2), du Carbone Inorganique Total et d'alcalinité totale dans les eaux de surface en association avec les mesures hydrologiques et biogéochimiques in-situ et avec l'aide de données satellitaires (température, couleur de la mer). Les parcours logistiques de l'Astrolabe, permettent d'accéder à des zones très peu étudiées et de les documenter afin de comprendre les processus qui expliquent les variations spatio-temporelles de pCO2 à moyenne échelle dans les régions océaniques australes. Les données récoltées durant ces campagnes serviront de base pour faire des estimations de la variabilité interannuelle et de la variation moyenne (tendance) du flux net de CO2 à l'interface océan atmosphère. Les observations recueillies lors des campagnes MINERVE servent également à d'autres équipes pour contraindre des modèles atmosphériques et à valider des modèles biogéochimiques basés sur des modèles de circulation générale océanique qui tentent de simuler le cycle du carbone océanique à moyen et à long terme.
Diffusive Representations for the Numerical Evaluation of Fractional Integrals
Creators: name: Diethelm, Kai
Publisher: name: arXiv
Year: 2023
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 26A33

description: Diffusive representations of fractional differential and integral operators can provide a convenient means to construct efficient numerical algorithms for their approximate evaluation. In the current literature, many different variants of such representations have been proposed. Concentrating on Riemann-Liouville integrals whose order is in (0,1), we here present a general approach that comprises most of these variants as special cases and that allows a detailed investigation of the analytic properties of each variant. The availability of this information allows to choose concrete numerical methods for handling the representations that exploit the specific properties, thus allowing to construct very efficient overall methods.
description: 6 pages
JURNAL AGAMA ASYIFA HARIS N.pdf
Creators: name: Nindyasari, Asyifa Haris
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 420503
subject: Community and primary care

description: Penelitian ini mengkaji implementasi nilai-nilai adab dalam menuntut ilmu menurut pandangan Imam Al-Ghazali di lembaga pendidikan Islam kontemporer. Imam Al-Ghazali menekankan pentingnya adab dalam mencari ilmu, seperti sikap tawadhu, penghormatan terhadap guru, dan niat yang ikhlas. Penelitian ini mengeksplorasi bagaimana nilai-nilai tersebut diterapkan dalam setting pendidikan Islam modern, serta tantangan yang dihadapi oleh lembaga pendidikan dalam penerapannya. Penelitian ini menyoroti relevansi prinsip-prinsip Al-Ghazali dalam membentuk karakter siswa dan guru, serta menciptakan budaya saling menghormati, kedisiplinan, dan kerendahan hati intelektual. Penelitian ini juga membahas peran teknologi, hubungan guru dan siswa, serta integrasi nilai-nilai etika Islam dalam praktik pendidikan sehari-hari. Sebagai kesimpulan, makalah ini memberikan rekomendasi untuk penerapan nilai-nilai ini secara lebih efektif di lingkungan pendidikan modern untuk menciptakan pengalaman pendidikan yang holistik, yang tidak hanya mengembangkan intelektual tetapi juga perkembangan moral dan spiritual siswa.
title: Ziviler Ungehorsam als legitimes "Notkorrektiv" in einer Demokratie?
title: Erörterung am Fallbeispiel Ende Gelände, Rheinisches Braunkohlerevier
titleType: Subtitle
Creators: name: Adams, Maike Naomi
Publisher: name: Medien- und Informationszentrum, Leuphana Universität Lüneburg
Year: 2020
Subjects: classificationCode: 303
subject: 303 Gesellschaftliche Prozesse

description: Der Konflikt um den Braunkohleabbau im Allgemeinen und den Hambacher Forst im Speziellen ist im Sommer 2018 in Deutschland erneut eskaliert und fand eine immer breitere Wahrnehmung in der Öffentlichkeit. Der Protest im und um den Hambacher Forst steht symbolisch für die Auseinandersetzungen um die deutsche Klimapolitik und damit für die Machtverhältnisse zwischen Staat, Wirtschaft und Zivilgesellschaft. Akteure verschiedener Standpunkte mussten in diesem Konflikt ihre Position begründen. Dies führte zu einer Intensivierung der Diskussion um Legalität, Legitimität, Demokratie und Gerechtigkeit. Die scheinbare Diskrepanz zwischen einer rechtsstaatlichen Demokratie und dem zivilen Ungehorsam als einem möglichen Korrektiv führte zu der hier bearbeiteten Forschungsfrage: Ist der Einsatz von zivilem Ungehorsam am Fallbeispiel "Ende Gelände", Rheinisches Braunkohle Revier, legitim, wenn nicht sogar notwendig, um die Grundprinzipien des demokratischen Staates zu wahren? Als Grundlage für die Beantwortung der Fragestellung soll erörtert werden, ob in der rechtsstaatlichen, sozialen und repräsentativen Demokratie Deutschlands die Protestform des zivilen Ungehorsams legitim sein kann und, sofern dies der Fall ist, unter welchen Umständen diese Legitimität gegeben ist.
La colonizzazione giuridica dell'Eritrea: diritto coloniale tra scienza giuridica, antropologia, etnografia giuridica (1880-1912)
Creators: name: Panza, Valerio
Publisher: name: Università degli Studi di Napoli Federico II
Year: 2015

description: I caratteri e gli sviluppi della "cultura giuridica" della colonizzazione nel periodo 1880-1912, attraverso l'analisi del ruolo del diritto come strumento di rappresentazione e di legittimazione dell'ordine coloniale e in rapporto al parallelo sviluppo delle discipline etno-antropologiche in Italia
EFFECTIVE METHODS OF TEACHING ENGLISH TO YOUNG LEARNERS
Creators: name: Tilovova Mahliyo Uzbekistan State World Languages University Faculty of English  Philology
Publisher: name: Zenodo
Year: 2025

description: This paper explores contemporary methodologies for teaching English to young learners, highlighting the ongoing evolution of instructional strategies in educational settings. The field of English language pedagogy has undergone significant advancements, integrating diverse approaches tailored to learners' cognitive and linguistic needs. By examining both traditional and innovative techniques, this study aims to identify the most effective strategies that foster engagement, comprehension, and long-term language retention. Furthermore, the discussion emphasizes the role of interactive, task-based, and technology-enhanced learning environments in optimizing the acquisition of English as a second language.
PANDUAN PRAKTIS SHALAT BERJAMA'AH
Creators: name: Rasyid, Daud
Publisher: name: Usamah Press
Year: 2015
Subjects: Shalat
Jama'ah
Shaf
Masjid
Imam
Ma'mum

description: Buku tipis ini menjelaskan tentang pelaksanaan Shalat Berjamaah, seperti Shalat lima waktu, dilengkapi dengan gambar di beberapa tempat. Pelaksanaan Shalat Berjamaah di tengah umat Islam banyak yang harus dikoreki, seperti shaf yang jarang, mendahului Imam, dan seterusnya. Inilah yang menjadi bahasan buku kecil ini. Semoga bermanfaat.
MINERVE 2015 cruise,L'Astrolabe R/V
Creators: name: TOURATIER Franck
Publisher: name: Sismer
Year: 2015

description: Estimation de la tendance de l'évolution du système CO2 dans l'océan austral. Le programme MINERVE (Mesures à l'Interface Eau- aiR de la Variabilité des Echanges de CO2), qui s'appuie sur des campagnes océanographiques entre Hobart (Australie) et la terre Adélie (Base française en Antarctique), a pour objectif d'observer et de comprendre les variabilités saisonnières de la pression partielle de CO2 (pCO2), du Carbone Inorganique Total et d'alcalinité totale dans les eaux de surface en association avec les mesures hydrologiques et biogéochimiques in-situ et avec l'aide de données satellitaires (température, couleur de la mer). Les parcours logistiques de l'Astrolabe, permettent d'accéder à des zones très peu étudiées et de les documenter afin de comprendre les processus qui expliquent les variations spatio-temporelles de pCO2 à moyenne échelle dans les régions océaniques australes. Les données récoltées durant ces campagnes serviront de base pour faire des estimations de la variabilité interannuelle et de la variation moyenne (tendance) du flux net de CO2 à l'interface océan atmosphère. Les observations recueillies lors des campagnes MINERVE servent également à d'autres équipes pour contraindre des modèles atmosphériques et à valider des modèles biogéochimiques basés sur des modèles de circulation générale océanique qui tentent de simuler le cycle du carbone océanique à moyen et à long terme. Les projets de rattachement sont PROOF/LEFE (FLAMENCO2) et ORE CARAUS.
TRANSCRIPTION FACTORS AS TARGETS OF NEW MOLECULES WITH POTENTIAL ANTI-CANCER ACTIVITY
Creators: name: De Cicco, Paola
Publisher: name: Università degli Studi di Napoli Federico II
Year: 2015

description: Melanoma is the deadliest form of skin cancer and it is rising in incidence. Although in the past 3 years have been made notable advances in the understanding the molecular pathogenesis of melanoma and its treatment, melanoma therapy is still a challenge.  Therefore, it is critical to identify other important potential targets in melanoma development and progression that are amenable to pharmacological inhibition.
In the last few years, numerous physiological and pathophysiological effects have been proposed for the gasotransmitter hydrogen sulphide, even its role in cancer molecular mechanisms is still unclear. Recently, it has been shown that CSE enzyme is expressed in melanoma cell lines and that CBS enzyme plays a key role in colon and ovarian cancer.
Starting from these evidence, the aim of my PhD project was to investigate the role of the metabolic H2S pathway in human melanoma.
Our study have demonstrate that H2S inhibited melanoma cell proliferation inducing apoptosis and cell cycle arrest in G0/G1-phase.The main pro-apoptotic mechanisms involved were suppression of nuclear factor-kB activity and inhibition of the AKT and ERK pathways.The anti-proliferative role of H2S was also confirmed by the finding that the overexpression of CSE induced spontaneous apoptosis of human melanoma cells. A proof of concept was obtained in vivo using both a murine model of cutaneus melanoma and a murine model of metastatic melanoma. In fact, either L-cysteine, the CSE substrate, or DATS inhibited tumor growth and the development of lung metastases in mice. Finally, the immunohistochemistry analysis performed on
human melanoma samples demonstrated that CSE expression was highest in primary tumors, decreased in the
metastatic lesions and was almost silent in non-lymph node metastase whereas CBS and 3-MST do not appear to play an important role in human melanoma. These data support our hypothesis that CSE derived hydrogen sulfide plays a major role in melanoma.In conclusion, we have
determined that the L-cysteine/CSE/H2S pathway is involved in melanoma progression.
Modules for Experiments in Stellar Astrophysics (MESA)
Creators: name: Timmes, Frank
Publisher: name: Zenodo
Year: 2022

description: Software instrument: MESA solves the fully coupled structure and composition equations governing stellar evolution. MESA Project: The international community of MESA users encompasses more than 1000 users spanning more than 100 institutions in 27 countries, and has transformed research and education in stellar astrophysics. The MESA Project brings together astronomers, computer scientists, data scientists, and astrophysicists to work together on key questions in the field, and serves as a focal point for the international community by fostering open-knowledge exchanges. The MESA Project has led to a significant, new, expanding ecosystem of software instruments. More than 400 scientists – undergrads, grads, postdocs, faculty, and amateurs – have participated in a MESA Summer School, who are now creating their own MESA communities at more than 50 institutions world-wide. MESA is having a large impact on the field and is likely to be the gold standard for stellar astrophysics for the next generation of researchers.
An Alon-Tarsi Style Theorem for Additive Colorings
Creators: name: Gossett, Ian
Publisher: name: arXiv
Year: 2023
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: We first give an alternative proof of the Alon-Tarsi list coloring theorem. We use the ideas from this proof to obtain the following result, which is an additive coloring analog of the Alon-Tarsi Theorem: Let $G$ be a graph and let $D$ be an orientation of $G$. We introduce a new digraph $\mathcal{W}(D)$, such that if the out-degree in $D$ of each vertex $v$ is $d_v$, and if the number of Eulerian subdigraphs of $\mathcal{W}(D)$ with an even number of edges differs from the number of Eulerian subdigraphs of $\mathcal{W}(D)$ with an odd number of edges, then for any assignment of lists $L(v)$ of $d_v+1$ positive integers to the vertices of $G$, there is an additive coloring of $G$ assigning to each vertex $v$ an element from $L(v)$. As an application, we prove an additive list coloring result for tripartite graphs $G$ such that one of the color classes of $G$ contains only vertices whose neighborhoods are complete.
description: 12 pages. Preprint version. Peer-reviewed version to appear in Graphs and Combinatorics
Zukünftige Digitale Autorschaft
Creators: name: Dinger, Patrick
name: Horstmann, Jan
name: Jansky, Caroline
name: Jurczyk, Thomas
name: Steyer, Timo
Publisher: name: Zenodo
Year: 2025
Subjects: DHd2025
Poster
Zukunft des Publizierens
Large Language Models
Autorschaft
Datenpublikation
Teilen
Community-Bildung
Bewertung
Schreiben
Veröffentlichung
Kollaboration

description: Die DHd-AG Digitales Publizieren diskutiert mit diesem interaktiven Poster, aufbauend auf den Ergebnissen einer 2024 durchgeführten Community-Umfrage, verschiedene Dimensionen zukünftiger digitaler Autorschaft. In der Umfrage zeigt sich generell eine große Offenheit gegenüber neuen Formen und Inhalten des Publizierens in der DH-Community, hinsichtlich des Einsatzes von Large Language Models (LLM) und dem Verschwinden der individuellen Autorschaft aber auch eine gewisse Skepsis. Die Reputation, die mit der Publikation von Forschungsdaten einhergeht, muss in den kommenden Jahren noch weiter gestärkt werden. Die daraus resultierenden Fragen zu kollaborativer bzw. individueller Autorschaft, zur Rolle von LLMs beim Publizieren sowie zum Stellenwert von wissenschaftlichen Datensätzen für die Autorschaft möchten wir anhand des Posters mit der Community diskutieren.
Elementary Proof of QAOA Convergence
Creators: name: Binkowski, Lennart
name: Koßmann, Gereon
name: Ziegler, Timo
name: Schwonnek, René
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The Quantum Alternating Operator Ansatz (QAOA) and its predecessor, the Quantum Approximate Optimization Algorithm, are one of the most widely used quantum algorithms for solving combinatorial optimization problems. However, as there is yet no rigorous proof of convergence for the QAOA, we provide one in this paper. The proof involves retracing the connection between the Quantum Adiabatic Algorithm and the QAOA, and naturally suggests a refined definition of the `phase separator' and `mixer' keywords.
description: 10 pages, 2 figures
MINERVE 2015/2016 cruise,L'Astrolabe R/V
Creators: name: TOURATIER Franck
name: GOYET Catherine
Publisher: name: Sismer
Year: 2015

description: Estimation de la tendance de l'évolution du système CO2 dans l'océan austral. Le programme MINERVE (Mesures à l'Interface Eau- aiR de la Variabilité des Echanges de CO2), qui s'appuie sur des campagnes océanographiques entre Hobart (Australie) et la terre Adélie (Base française en Antarctique), a pour objectif d'observer et de comprendre les variabilités saisonnières de la pression partielle de CO2 (pCO2), du Carbone Inorganique Total et d'alcalinité totale dans les eaux de surface en association avec les mesures hydrologiques et biogéochimiques in-situ et avec l'aide de données satellitaires (température, couleur de la mer). Les parcours logistiques de l'Astrolabe, permettent d'accéder à des zones très peu étudiées et de les documenter afin de comprendre les processus qui expliquent les variations spatio-temporelles de pCO2 à moyenne échelle dans les régions océaniques australes. Les données récoltées durant ces campagnes serviront de base pour faire des estimations de la variabilité interannuelle et de la variation moyenne (tendance) du flux net de CO2 à l'interface océan atmosphère. Les observations recueillies lors des campagnes MINERVE servent également à d'autres équipes pour contraindre des modèles atmosphériques et à valider des modèles biogéochimiques basés sur des modèles de circulation générale océanique qui tentent de simuler le cycle du carbone océanique à moyen et à long terme. Les dates des traversées entre Hobart et Dumont D'Urville pour les campagnes de lancement d'XBT sont les suivantes (4 rotations) : - R1 du 28/11/2015 au 24/12/2015 - R2 du 02/01/2016 au 25/01/2016 - R3 du 31/01/2016 au 18/02/2016 - R4 du 20/02/2016 au 05/03/2016. Les projets de rattachement sont PROOF/LEFE (FLAMENCO2) et ORE CARAUS.
MINERVE 2016/2017 cruise,L'Astrolabe R/V
Creators: name: TOURATIER Franck
name: GOYET Catherine
Publisher: name: Sismer
Year: 2016

description: Estimation de la tendance de l'évolution du système CO2 dans l'océan austral. Le programme MINERVE (Mesures à l'Interface Eau- aiR de la Variabilité des Echanges de CO2), qui s'appuie sur des campagnes océanographiques entre Hobart (Australie) et la terre Adélie (Base française en Antarctique), a pour objectif d'observer et de comprendre les variabilités saisonnières de la pression partielle de CO2 (pCO2), du Carbone Inorganique Total et d'alcalinité totale dans les eaux de surface en association avec les mesures hydrologiques et biogéochimiques in-situ et avec l'aide de données satellitaires (température, couleur de la mer). Les parcours logistiques de l'Astrolabe, permettent d'accéder à des zones très peu étudiées et de les documenter afin de comprendre les processus qui expliquent les variations spatio-temporelles de pCO2 à moyenne échelle dans les régions océaniques australes. Les données récoltées durant ces campagnes serviront de base pour faire des estimations de la variabilité interannuelle et de la variation moyenne (tendance) du flux net de CO2 à l'interface océan atmosphère. Les observations recueillies lors des campagnes MINERVE servent également à d'autres équipes pour contraindre des modèles atmosphériques et à valider des modèles biogéochimiques basés sur des modèles de circulation générale océanique qui tentent de simuler le cycle du carbone océanique à moyen et à long terme. Les dates des traversées entre Hobart et Dumont D'Urville pour les campagnes de lancement d'XBT sont les suivantes (1 rotation) : R1 du 13/12/2016 au 04/01/2017.
PEDAGOGICAL AND PSYCHOLOGICAL IMPORTANCE OF MANAGEMENT COMPETENCE
Creators: name: Umbarova Sabohat Hamza qizi  Bucheon University in Tashkent  "Educational Management"  Master's degree I student
Publisher: name: Zenodo
Year: 2025

description: Rahbarlik kompetensiyasi, rahbarning strategik fikrlash, qaror qabul qilish, jamoani boshqarish va motivatsiya berish kabi ko`nikmalar bilan namoyon bo`ladi. Emotsional intellekt tushunchasi esa shaxsning o`z his-tuyg`ularini anglash va boshqarish, boshqalarning hissiyotlariga nisbatan empatiya ko`rsatish, samarali muloqot va ijtimoiy munosabatlarni mustahkamlash qobiliyatidir. Maqola esa, ushbu ikki tushunchaning uyg`unligi nafaqat rahbarning individual rivojlanishida, balki tashkilotning umumiy samaradorligini oshirishda ham muhim ahamiyatga ega ekanligi haqida bayon etadi. Zamonaviy boshqaruv tizimida strategik fikrlash va to`g`ri qaror qabul qilish jarayonlari rahbarning nafaqat texnik bilim va tajribasiga, balki uning emotsional barqarorligiga ham bog`liqdir. Rahbarlik kompetensiyasi va emotsional intellektning uyg`unligi zamonaviy rahbarlar uchun asosiy talab bo`lib, bu jarayonni o`rganish orqali ta’lim muassasasining barqaror rivojlanishini ta’minlash mumkin. Maqola aynan ushbu tushunchalar yordamida keng yoritilgan.
MINERVE 2017 cruise,L'Astrolabe R/V
Creators: name: FALCO Cédric
name: TOURATIER Franck
name: GOYET Catherine
Publisher: name: Sismer
Year: 2017

description: Estimation de la tendance de l'évolution du système CO2 dans l'océan austral. Le programme MINERVE (Mesures à l'Interface Eau- aiR de la Variabilité des Echanges de CO2), qui s'appuie sur des campagnes océanographiques entre Hobart (Australie) et la terre Adélie (Base française en Antarctique), a pour objectif d'observer et de comprendre les variabilités saisonnières de la pression partielle de CO2 (pCO2), du Carbone Inorganique Total et d'alcalinité totale dans les eaux de surface en association avec les mesures hydrologiques et biogéochimiques in-situ et avec l'aide de données satellitaires (température, couleur de la mer). Les parcours logistiques de l'Astrolabe, permettent d'accéder à des zones très peu étudiées et de les documenter afin de comprendre les processus qui expliquent les variations spatio-temporelles de pCO2 à moyenne échelle dans les régions océaniques australes. Les données récoltées durant ces campagnes serviront de base pour faire des estimations de la variabilité interannuelle et de la variation moyenne (tendance) du flux net de CO2 à l'interface océan atmosphère. Les observations recueillies lors des campagnes MINERVE servent également à d'autres équipes pour contraindre des modèles atmosphériques et à valider des modèles biogéochimiques basés sur des modèles de circulation générale océanique qui tentent de simuler le cycle du carbone océanique à moyen et à long terme.
Novel tools for the elucidation of physio-pathological role of H2S
Creators: name: Corvino, Angela
Publisher: name: Università degli Studi di Napoli Federico II
Year: 2015

description: Hydrogen sulphide is endogenously synthesized mainly by two pyridoxal-5′-phosphate-dependent
enzymes involved in L-cysteine metabolism: cystathionine-ß-synthase (CBS) and cystathionine-γ-
lyase (CSE). The H2S pathway has been proposed to be involved in the pathophysiology of several
diseases. At the present stage the research in this field is impaired by the lack of pharmacological
tools such as selective enzymatic inhibitors. The goal of our study is the development compounds
that selectively regulate enzymatic activity. Here we present the synthesis and the activity of a
selective CSE inhibitor.
We preliminarily selected and tested commercially available cysteine surrogates because of the
unavailability of a pharmacophoric model as a lead for rational design of targeted enzyme
inhibitors. The catalytic profiles of recombinant CBS and CSE were assessed in the presence of
the selected compounds. On the basis of the results obtained were designed new compounds
aiming to obtain novel molecular entities embodying the structural features of both cysteine and the
well known CSE inhibitor, DL-propargylglycine. The synthetically modified compounds, obtained in
our laboratory, were tested in vitro by using rat aortic rings. The compound showing maximal
inhibitory effects in this test was an oxothiazolidine derivative, dubbed compound VII. The effects
of this compound on the enzyme kinetics was further tested on the purified enzymes using a
metabolomic approach based on nuclear magnetic resonance techniques. These studies clearly
showed that compound VII is a potent enzyme inhibitor of CSE, without affecting the CBS
kinetics. The identification of this highly selective CSE inhibitor may help to better define the role of
CSE vs CBS in the pathophysiology of the diseases where a role for the H2S pathway has been
proposed.
The Fourier transform in weighted rearrangement invariant spaces
Creators: name: Mastyło, Mieczysław
name: Sinnamon, Gord
Publisher: name: arXiv
Year: 2023
Subjects: subject: Functional Analysis (math.FA)
subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35B30 (Primary) 42B15 (Secondary)

description: It is shown that if the Fourier transform is a bounded map on a rearrangement-invariant space of functions on $\mathbb R^n$, modified by a weight, then the weight is bounded above and below and the space is equivalent to $L^2$. Also, if it is bounded from $L^p$ to $L^q$, each modified by the same weight, then the weight is bounded above and below and $1\le p=q'\le 2$. Applications prove the non-boundedness on these spaces of an operator related to the Schrödinger equation.
description: 9 pages, no figures
title: "Ratto di Proserpina", Bernini Gian Lorenzo, inv. CCLXVIII (ITA/EN)
title: Scheda catalogo digitale Borghese
titleType: AlternativeTitle
Creators: name: Felici, Sonja
name: Galleria Borghese
Publisher: name: Galleria Borghese
Year: 2024

description: Pubblicazione delle schede delle opere conservate nel museo ed estratte dal catalogo digitale di Galleria Borghese, nelle due versioni esistenti online, in italiano e inglese.

Collegamento al catalogo digitale:

ITA: https://www.collezionegalleriaborghese.it/

EN: https://www.collezionegalleriaborghese.it/en
Asymptotic expansions of stable, stabilizable and stabilized means with applications
Creators: name: Mihoković, Lenka
Publisher: name: arXiv
Year: 2023
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: 26E60, 41A60, 39B22

description: In this paper we present a complete asymptotic expansion of a symmetric homogeneous stable (balanced), stabilizable and stabilized mean. By including known asymptotic expansions of parametric means it is shown how the obtained coefficients are used to solve the problem of identifying stable means within classes of parametric means under consideration, how to disprove some mean is stabilizable or stabilized and how to obtain best possible parameters such that given mean is stabilizable with some pair of parametric means.
Deliverable 4.1 1st update on specialist workshops, training courses and individual exchanges
Creators: name: Wageningen University
Publisher: name: Zenodo
Year: 2005
Subjects: NoE and NEXUS Projects
The EuroFIR Food Platform
EuroFIR

description: 4.1. Workshop - Pitfalls and challenges in reporting food composition data

During the EuroFIR NEXUS meeting prior to the 9th IFDC conference on 12th -13th September 2011 the workshop was organised at the NBI Conference Center, Norwich, UK

This workshop for compilers was organised by Dr Jayne Ireland & Anders Møller, DFI [DK], Susanne Westenbrink, RIVM [NL] and Marine Oseredczuk, ANSES [FR] with the topic: ‘Pitfalls and Challenges in Reporting Food Composition Data’.

At the beginning of the workshop an introduction and purpose were presented. Thereafter

- Review critical steps in the EuroFIR Compilation Flow Chart and - Discussions focussing on 3-4 Critical Points were held.
MINERVE 2018 cruise,L'Astrolabe R/V
Creators: name: TOURATIER Franck
Publisher: name: Sismer
Year: 2018

description: Estimation de la tendance de l'évolution du système CO2 dans l'océan austral.Le programme MINERVE (Mesures à l'Interface Eau- aiR de la Variabilité des Echanges de CO2), qui s'appuie sur des campagnes océanographiques entre Hobart (Australie) et la terre Adélie (Base française en Antarctique), a pour objectif d'observer et de comprendre les variabilités saisonnières de la pression partielle de CO2 (pCO2), du Carbone Inorganique Total  et d'alcalinité totale dans les eaux de surface en association avec les mesures hydrologiques et biogéochimiques in-situ et avec l'aide de données satellitaires (température, couleur de la mer). Les parcours logistiques de l'Astrolabe, permettent d'accéder à des zones très peu étudiées et de les documenter afin de comprendre les processus qui expliquent les variations spatio-temporelles de pCO2 à moyenne échelle dans les régions océaniques australes. Les données récoltées durant ces campagnes serviront de base pour faire des estimations de la variabilité interannuelle et de la variation moyenne (tendance) du flux net de CO2 à l'interface océan atmosphère.  Les observations recueillies lors des campagnes MINERVE servent également à d'autres équipes pour contraindre des modèles atmosphériques et à valider des modèles biogéochimiques basés sur des modèles de circulation générale océanique qui tentent de simuler le cycle du carbone océanique à moyen et à long terme.Le projet de rattachement est SNO COOL.
title: Welche Zukünfte?
Creators: name: Assmann, Aleida
Publisher: name: Bauhaus-Universität Weimar
Year: 2017
Subjects: subject: Fortschritt
subject: Ungewissheit
subject: Nachhaltigkeit
subject: 300

description: Vortrag, gehalten am 20.04.2017 zur Einführung von Prof. Dr. Winfried Speitkamp in das Amt des Präsidenten der Bauhaus-Universität Weimar
description: Neue Bauhausvorträge, vol. 1
Synthesis of New Ligands of Urokinase
Receptor and New Urotensin-II
Derivatives
Creators: name: Yousif, Ali Munaim
Publisher: name: Università degli Studi di Napoli Federico II
Year: 2015

description: Unit 1: The urokinase-type plasminogen activator receptor (uPAR) is involved in the regulation of cell
migration. The uPAR is formed by three domains connected by short linker region. The Ser88-Arg-Ser-
Arg-Tyr92 is the minimum chemotactic sequence of uPAR required to induce the same intracellular
signaling as result of its binding with formyl peptide receptor (FPRs). With aim to perform a SAR
study on this sequence we have synthesized a large peptide library using phosphorylated amino acids,
non-coded amino acids, D-amino acid scan and cyclic analogues. A new two potent inhibitors of cell
migration, uPAR2 and uPAR18, have been identified represented, respectivetly, by the analogue with
phosphorylated Ser90 and the analogue with cyclic conformation.
Unit 2: Urotensin II (U-II), is a cyclic peptid has been described as the most potent vasoconstrictor
documented. The vasocontriction effect of U-II is a result of the binding with its receptor UT receptor.
The cyclic region of U-II, c[Cys-Phe-Trp-Lys-Tyr-Cys], plays an essential role in terms of affinity for
UT receptor. We developed new two different libraries of U-II analogues carried structure
modification on the peptide bond to explore new SARs on the cyclic region of U-II. Peptoids
analogues represent the first library whose the side chain are appended to N-atom rather than the α-
Carbon. The second library represented by N-aminosulfamide analogues (azasulfurylpeptides), a class
of peptidomimetics, in which the CαH and the carbonyl are respectively replaced by a nitrogen atom
and a sulfonyl group.
Deliverable 2.8 EuroFIR Web Services: Specifications for EuroFIR request- response based Web services
Creators: name: THL
Publisher: name: Zenodo
Year: 2005
Subjects: NoE and NEXUS Projects
The EuroFIR Food Platform
EuroFIR

description: SUMMARY

EuroFIR Web Services provide an interface for the food composition information data interchange. This specification defines the interface for these EuroFIR Web services and the format for the requests and responses. Moreover, the specification defines the authentication methods. The requests use specially designed Food Data Query Language (FDQL) which is part of the specification. The responses use Food Data Transport Package for delivering food composition information and specially designed Meta Data Transport Package for delivering metainformation. The current version of the EuroFIR Web Services supports Simple Object Access (SOAP) protocol. In addition a simplified specification using Representational State Transfer (REST) protocol is included.
Effect of electronic correlation on topological end-states in finite-size graphene nanoribbons
Creators: name: Honet, Antoine
name: Henrard, Luc
name: Meunier, Vincent
Publisher: name: arXiv
Year: 2023
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Finite size armchair graphene nanoribbons (GNR) of different families are theoretically studied using the Hubbard model in both mean-field and GW approximations, including spin correlation effects. It is shown that correlation primarily affect the properties of topological end states of the nanoribbons. A representative structure of each of the three GNR families is considered but the 7-atom width nanoribbon is studied in detail and compared to experimental results, showing a clear improvement when correlations are included. Using on numerically computed local density of states, spin-polarized measurements in scanning tunneling microscopy are also suggested to help distinguish and highlight correlation effects.
MINERVE 2018-2019 cruise,L'Astrolabe R/V
Creators: name: TOURATIER Franck
Publisher: name: Sismer
Year: 2018

description: Le but du programme MINERVE (Mesures à l'INterface Eau-aiR de la Variabilité des Echanges de CO2), qui s'appuie sur des campagnes de valorisation de transit, est d'observer et de comprendre les variabilités saisonnières de la pression partielle de CO2 (pCO2) et du Carbone Inorganique Total dans les eaux de surface en association avec les mesures hydrologiques et biogéochimiques in-situ et avec l'aide de données satellitaires (température, couleur de la mer). Les parcours logistiques de l'Astrolabe, permettent d'accéder à des zones très peu étudiées et de les documenter afin de comprendre les processus qui expliquent les variations spatio-temporelles de pCO2 à moyenne échelle dans les régions océaniques australes. Les données récoltées durant ces campagnes servent de base pour faire des estimations de la variabilité interannuelle et de la variation moyenne (tendance) du flux net de CO2 à l'interface océan-atmosphère. En identifiant et quantifiant des sources et puits de CO2, les observations recueillies lors des campagnes MINERVE servent également à d'autres équipes pour contraindre des modèles atmosphériques et à valider des modèles biogéochimiques basés sur des modèles de circulation générale océanique qui tentent de simuler le cycle du carbone océanique à moyen et à long terme.
MINERVE 90 cruise,Marion Dufresne R/V
Creators: name: POISSON Alain
Publisher: name: Sismer
Year: 1990

description: Quantification du flux de CO2 à l'interface océan-atmosphère. Etude des variabilités spatio-temporelles de la distribution de la pression partielle de CO2 dans les eaux de surface océaniques. Zone d'étude : Océan Indien. Echelles de temps : variabilité saisonnière, interannuelle. Cette campagne englobe toutes les campagnes MINERVE de 1990 c'est à dire MINERVE 90-01 a MINERVE 90-06.
MINERVE 91 cruise,Marion Dufresne R/V
Creators: name: POISSON Alain
Publisher: name: Sismer
Year: 1991

description: Quantification du flux de CO2 à l'interface océan/atmosphère. Etude des variabilités spatio-temporelles de la distribution de la pression partielle de CO2 dans les eaux de surface océaniques. Zone d'étude : Océan Indien. Echelles de temps : variabilité saisonnière, interannuelle. Cette campagne englobe toutes les campagnes MINERVE de 1991 (MINERVE 91-07 à MINERVE 91-13).
title: Analysis and Optimal Design of Wind Tunnel Balances
Creators: name: Twu, Sung-Ling
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 1985

description: The problem of finding the optimal cross-sectional shape of the elastic cage in wind tunnel balance is formulated and solved numerically. A mathematical model to implement the boundary condition associated with the elastic rigid connection into the finite element method is discussed. Numerical results show that the rigid connection at the end of the elastic cage has significant effect on the stress distribution.

The finite dimensional approach for a three dimensional design sensitivity analysis is derived. Using both the free and rigid boundary conditions, numerical examples are performed and comparisons of the accuracy of design sensitivity analysis between the proposed approach and the direct difference approach are made.

Finally, an iterative shape optimization algorithm is used to optimally design the geometric characteristics of the elastic cage of a loaded wind tunnel balance, subject to the given performance requirement.
Revisitation of the lock-in transition in one-dimensional charge-density waves
Creators: name: Inagaki, Katsuhiko
name: Nakatsugawa, Keiji
name: Tanda, Satoshi
Publisher: name: arXiv
Year: 2023
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We studied the lock-in transition of charge-density waves of one-dimensional conductors. Though this phenomenon has been known for decades, there are still discrepancies between the theories and the experiments. We focused on the pioneering study of this phenomenon by McMillan and revisited, in particular, his numerical calculations. We first reproduced his results by providing unwritten information in the article. The obtained critical point was in good agreement with the previous study, as well as the analytical solution proposed later. We found a simple power-law behavior of the free energy in the critical regime, leading to the power-law divergence of the specific heat. We also introduced the concept of stiffness, equivalent to helicity modulus, which also showed a power-law behavior. These results allowed us to propose a new perspective on the lock-in transition.
description: 12 pages, 4 figures
Surfaces of genus $g\geq 1$ in 3D contact sub-Riemannian manifolds
Creators: name: Bellini, Eugenio
name: Boscain, Ugo
Publisher: name: arXiv
Year: 2023
Subjects: subject: Differential Geometry (math.DG)
subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 53D10 / 53C17 / 93B03

description: We consider surfaces embedded in a 3D contact sub-Riemannian manifold and the problem of the finiteness of the induced distance (i.e., the infimum of the length of horizontal curves that belong to the surface). Recently it has been proved that for a surface having the topology of a sphere embedded in a tight co-orientable structure, the distance is always finite. In this paper we study closed surfaces of genus larger than 1, proving that such surfaces can be embedded in such a way that the induced distance is finite or infinite. We then study the structural stability of the finiteness/not-finiteness of the distance.
MINERVE 92 cruise,Marion Dufresne R/V
Creators: name: POISSON Alain
Publisher: name: Sismer
Year: 1992

description: Quantification du flux de CO2 à l'interface océan-atmosphère. Etude des variabilités spatio-temporelles de la distribution de la pression partielle de CO2 dans les eaux de surface océaniques. Zone d'étude : Ocean Indien - Echelles de temps : variabilité saisonnière, interannuelle. Cette campagne englobe toutes les campagnes MINERVE de 1992 c'est à dire de MINERVE 92-14 à MINERVE 92-21.
title: Freiräume. Historische Hinweise zur Füllung einer Leerstelle
Creators: name: Laak, Dirk van
Publisher: name: Bauhaus-Universität Weimar
Year: 2018
Subjects: subject: Freiraum
subject: 710

description: Vortrag, gehalten am 22.11.2017 anlässlich des Wissenschaftstages an der Bauhaus-Universität Weimar
description: Neue Bauhausvorträge, vol. 4
MINERVE 93 cruise,Marion Dufresne R/V
Creators: name: POISSON Alain
Publisher: name: Sismer
Year: 1993

description: Quantification du flux de CO2 à l'interface océan/atmosphère. Etude des variabilités spatio-temporelles de la distribution de la pression partielle de CO2 dans les eaux de surface océaniques. Zone d'étude : Ocean Indien. Echelles de temps : variabilité saisonnière, interannuelle. Cette campagne englobe toutes les campagnes MINERVE de 1993 c'est à dire MINERVE 93-22 à MINERVE 93-28.
Testing of Deep Reinforcement Learning Agents with Surrogate Models
Creators: name: Biagiola, Matteo
name: Tonella, Paolo
Publisher: name: arXiv
Year: 2023
Subjects: subject: Software Engineering (cs.SE)
subject: Artificial Intelligence (cs.AI)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences
subject: D.2.5

description: Deep Reinforcement Learning (DRL) has received a lot of attention from the research community in recent years. As the technology moves away from game playing to practical contexts, such as autonomous vehicles and robotics, it is crucial to evaluate the quality of DRL agents. In this paper, we propose a search-based approach to test such agents. Our approach, implemented in a tool called Indago, trains a classifier on failure and non-failure environment (i.e., pass) configurations resulting from the DRL training process. The classifier is used at testing time as a surrogate model for the DRL agent execution in the environment, predicting the extent to which a given environment configuration induces a failure of the DRL agent under test. The failure prediction acts as a fitness function, guiding the generation towards failure environment configurations, while saving computation time by deferring the execution of the DRL agent in the environment to those configurations that are more likely to expose failures. Experimental results show that our search-based approach finds 50% more failures of the DRL agent than state-of-the-art techniques. Moreover, such failures are, on average, 78% more diverse; similarly, the behaviors of the DRL agent induced by failure configurations are 74% more diverse.
Supplementary document for The Influence of Metal-semiconductor Junction on the Performances of Mixed-Dimensional MoS2/Ge Heterostructure Avalanche Photodetector - 5811341.pdf
Creators: name: Yuan, Xixi
name: Zhang, Ningning
name: Zhang, Tianyao
name: Meng, Lingyao
name: Zhang, Junming
name: Shao, Jifang
name: Liu, Maliang
name: Hui-Yong, Hu
name: Wang, Liming
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: supplemental document
MINERVE 94 cruise,Marion Dufresne R/V
Creators: name: POISSON Alain
Publisher: name: Sismer
Year: 1994

description: Etude des concentrations de CO2 dans les eaux de surface, variabilité spacio-temporelle, relations PCO2/chlorophylle au printemps austral. Corrélation aux mesures hydrologiques et biogéochimiques in situ avec l'aide des données satellitaires (température, couleur de la mer, vent). L'étude porte à la fois sur des zones oligotrophes subtropicales, zones d'upwelling intense, zones frontales. Les données servent à contraindre les modèles de circulation générale qui simulent les cycles du carbone océanique à moyen et long terme. Il s'agit de compléter les mesures dans l'Océan Indien ; certaines zones n'ont pas encore été étudiées, ou très peu. Cette campagne est la 29ème des campagnes MINERVE.
MINERVE 95 cruise,Marion Dufresne R/V
Creators: name: POISSON Alain
Publisher: name: Sismer
Year: 1995

description: Description et compréhension des variabilités spatio-temporelles de la fugacité du CO2 à la surface des océans et des flux de CO2. Le projet de rattachement est PNEDC-CO2/ESCO3A. MINERVE 95 est une campagne qui englobe toutes les campagnes MINERVE de 1995 de MINERVE 95-30 à MINERVE 95-33.
title: Über Axel Maliks "skripturale Methode"
Creators: name: Vogl, Joseph
Publisher: name: Bauhaus-Universität Weimar
Year: 2017
Subjects: subject: Kunst
subject: Grafik
subject: 700

description: Vortrag, gehalten am 20.08.2017 zur Eröffnung der Ausstellung "Die Bibliothek der unlesbaren Zeichen" im Audimax der Bauhaus-Universität Weimar
description: Neue Bauhausvorträge, vol. 3
An Analysis of the Johnson-Lindenstrauss Lemma with the Bivariate Gamma Distribution
Creators: name: Bernstein, Jason
name: Dunton, Alec M.
name: Priest, Benjamin W.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics

description: Probabilistic proofs of the Johnson-Lindenstrauss lemma imply that random projection can reduce the dimension of a data set and approximately preserve pairwise distances. If a distance being approximately preserved is called a success, and the complement of this event is called a failure, then such a random projection likely results in no failures. Assuming a Gaussian random projection, the lemma is proved by showing that the no-failure probability is positive using a combination of Bonferroni's inequality and Markov's inequality. This paper modifies this proof in two ways to obtain a greater lower bound on the no-failure probability. First, Bonferroni's inequality is applied to pairs of failures instead of individual failures. Second, since a pair of projection errors has a bivariate gamma distribution, the probability of a pair of successes is bounded using an inequality from Jensen (1969). If $n$ is the number of points to be embedded and $μ$ is the probability of a success, then this leads to an increase in the lower bound on the no-failure probability of $\frac{1}{2}\binom{n}{2}(1-μ)^2$ if $\binom{n}{2}$ is even and $\frac{1}{2}\left(\binom{n}{2}-1\right)(1-μ)^2$ if $\binom{n}{2}$ is odd. For example, if $n=10^5$ points are to be embedded in $k=10^4$ dimensions with a tolerance of $ε=0.1$, then the improvement in the lower bound is on the order of $10^{-14}$. We also show that further improvement is possible if the inequality in Jensen (1969) extends to three successes, though we do not have a proof of this result.
description: 20 pages, 5 figures. This revision improves figure 2 and format of citations