cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
exploRNN: teaching recurrent neural networks through visual exploration
Creators: name: Bäuerle, Alex
name: Albus, Patrick
name: Störk, Raphael
name: Seufert, Tina
name: Ropinski, Timo
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Neural network education
subject: Recurrent neural networks
subject: Sequential data
subject: DDC 000 / Computer science, information & general works
subject: Neural networks (Computer science)
subject: Visual education
subject: Neuronales Netz

description: Due to the success and growing job market of deep learning (DL), students and researchers from many areas are interested in learning about DL technologies. Visualization has been used as a modern medium during this learning process. However, despite the fact that sequential data tasks, such as text and function analysis, are at the forefront of DL research, there does not yet exist an educational visualization that covers recurrent neural networks (RNNs). Additionally, the benefits and trade-offs between using visualization environments and conventional learning material for DL have not yet been evaluated. To address these gaps, we propose exploRNN, the first interactively explorable educational visualization for RNNs. exploRNNis accessible online and provides an overview of the training process of RNNs at a coarse level, as well as detailed tools for the inspection of data flow within LSTM cells. In an empirical between-subjects study with 37 participants, we investigate the learning outcomes and cognitive load of exploRNN compared to a classic text-based learning environment. While learners in the text group are ahead in superficial knowledge acquisition, exploRNN is particularly helpful for deeper understanding. Additionally, learning with exploRNN is perceived as significantly easier and causes less extraneous load. In conclusion, for difficult learning material, such as neural networks that require deep understanding, interactive visualizations such as exploRNN can be helpful.
Analysis of vascularization in thyroid gland nodes with superb microvascular imaging (SMI) and CD34 expression histology: a pilot study
Creators: name: Studeny, Thomas
name: Kratzer, Wolfgang
name: Schmidberger, Julian
name: Graeter, Tilmann
name: Barth, Thomas F. E.
name: Hillenbrand, Andreas
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Ultrasound
subject: Thyroid
subject: Vascularisation
subject: Cancer
subject: Superb microvascular imaging
subject: COLOR-DOPPLER
subject: DATA SYSTEM
subject: MICROVESSEL DENSITY
subject: NODULES
subject: FLOW
subject: ULTRASONOGRAPHY
subject: DIFFERENTIATION
subject: ANGIOGENESIS
subject: ELASTOGRAPHY
subject: DDC 610 / Medicine & health

description: Abstract Background The Doppler sonography technique known as "superb microvascular imaging" (SMI) is advancing sonographic micro vascularization imaging in various disciplines. In this study, we aimed to determine whether SMI could reliably reproduce the blood flow in thyroid nodes and whether malignancy could be diagnosed, based on vascularization properties. Immunhistochemical staining by CD34 and SMI where used to determine the vascularization of nodes in terms of quantified vascularization parameters gained by computational evaluation. Methods We used image analysis programs to investigate whether the quantitative value for vascularization strength in the thyroid node, measured with SMI, was correlated with the actual degree of vascularization, determined microscopically. We included 16 patients that underwent thyroid resections. We prepared thyroid gland tissue slices for immunohistochemistry and labelled endothelial cells with CD34 to visualize blood vessels microscopically. We used image analysis programs, ImageJ, to quantify SMI Doppler sonographic measurements and CellProfiler to quantify CD34 expression in histological sections. We evaluated the numeric values for diagnostic value in node differentiation. Furthermore, we compared these values to check for correlations. Results Among the 16 nodes studied, three harboured malignant tumours (18.75%): two papillary and one follicular carcinoma. Among the 13 benign lesions (81.25%), four harboured follicular adenomas. Malignant and benign nodes were not significantly different in sonographic (0.88 ± 0.89 vs. 1.13 ± 0.19; p = 0.2790) or immunohistochemical measurements of vascularization strength (0.05 ± 0.05 vs. 0.08 ± 0.06; p = 0.2260). Conclusion We found a positive, significant correlation (r = 0.55588; p = 0.0254) between SMI (quantitative values for vascularization strength) and immunohistochemistry (CD34 staining) evaluations of thyroid nodes.
Short-term outcome of fragility fractures of the pelvis in the elderly treated with screw osteosynthesis and external fixator
Creators: name: Schuetze, Konrad
name: Eickhoff, Alexander
name: Dehner, Christoph
name: Blidon, Alexander
name: Gebhard, Florian
name: Richter, Peter Hinnerk
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Pelvic fracture
subject: Sacral fracture
subject: Fragility fracture
subject: Navigation
subject: Geriatric trauma
subject: SACROILIAC SCREWS
subject: INTERNAL FIXATOR
subject: RING FRACTURES
subject: STABILIZATION
subject: COMPLICATIONS
subject: PAIN
subject: DDC 610 / Medicine & health

description: Abstract Background The treatment of fragility fractures of the pelvis is rising challenge for orthopedic trauma surgeons. Operative treatment should allow immediate full weight bearing and early mobilisation but should also be as minimal invasive as possible. Sacroiliac (SI) or transsacral transiliac screws (TSTI) alone or depending on the fracture in combination with an external fixator meets both of these criteria. Material and methods The outcome of 121 operatively treated patients with fragility fractures of the pelvis were evaluated in this retrospective study. Depending on the type of fracture the patients were treated with navigated SI screw or TSTI screw alone or in combination with an external fixator. All patients were operated in supine position in a hybrid-OR, which consists of a fixed robotic 3D flatpanel detector (Artis zeego, Siemens Healthineers, Germany) and a navigation system (BrainLab Curve, BrainLab, Germany). Results 37 patients were treated with either one or two SI screws and 57 with one TSTI screw. An additional external fixator was combined with SI screws in 17 patients and with TSTI screws in 10 patients. The preoperative pain score was significantly higher compared to the postoperative score (5.1 ± 2.5 vs 2.2 ± 1.9, p < 0.05). Follow-up at 6 month was possible for 106 patients which showed screw loosening in 16.3% of the SI Screws (n = 49) compared to only 5.2% of TSTI screws (n = 57). No screw loosening was seen in the combination of TSTI-screw and external fixator (n = 10). There were two septic and three aseptic pin loosenings of the external fixator. Overall only one patient needed revision surgery due to screw loosening and local irritation. Overall 75.2% (n = 91) of the patients could be released in their home or in a rehabilitation unit and only 14% (n = 17) were released to a nursing home due to immobility despite the operation. Non-surgical complications rate was 21.5%. Conclusion SI or TSTI screws with possible combination with an external fixator show early pain relief and allows most of the patients to keep their former level of independence. With an also low surgical complication rate, it proved to be a safe and reliable treatment for fragility fractures of the pelvis. Due the effective pain relief and the minimal invasive approach, early mobilisation is possible and might prevent typical non-surgical complications which are very common during conservative treatment.
Polygenic risk score: clinically useful tool for prediction of cardiovascular disease and benefit from lipid-lowering therapy?
Creators: name: Arnold, Natalie
name: Koenig, Wolfgang
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Genetic risk scores
subject: Prediction
subject: Cardiovascular disease
subject: Response to treatment
subject: Precision medicine
subject: DDC 610 / Medicine & health

description: Abstract Improvement in risk prediction of atherosclerotic cardiovascular disease (ASCVD) using information on the genetic predisposition at an individual level might offer new possibilities for the successful management of such complex trait. Latest developments in genetic research with the conduction of genome-wide association studies have facilitated a broader utility of polygenic risk score (PRS) as a potent risk prognosticator, being strongly associated with future cardiovascular events. Although its discriminative ability beyond traditional risk factors is still a matter of controversy, PRS possesses at least comparable risk information to that provided by traditional risk tools. More importantly, increased genetic risk for ASCVD might be discovered at younger ages, much longer before conventional risk factors become manifest, thereby providing a potent instrument for aggressive primordial and primary prevention in those at high risk. Furthermore, there is strong evidence that inherited risk may be successfully modulated by a healthy lifestyle or medication use (e.g., statins or PCSK-9 inhibitors). Here, we provide a short overview of the current research related to the possible application of PRS in clinical routine and critically discuss existing pitfalls, which still limit a widespread utility of PRS outside a research setting.
title: Syrian Refugees, Water Scarcity, and Dynamic Policies: How Do the New Refugee Discourses Impact Water Governance Debates in Lebanon and Jordan?
Creators: name: Hussein, Hussam
name: Natta, Alberto
name: Yehya, Abed Al Kareem
name: Hamadna, Baha
Publisher: name: Universität Kassel
Year: 2020
Subjects: subject: hydropolitics
subject: Lebanon
subject: Jordan
subject: Syrian crisis
subject: water scarcity
subject: discourse analysis
subject: 320
subject: 630

description: Gefördert durch den Publikationsfonds der Universität Kassel
Multi-scale image analysis and prediction of visual field defects after selective amygdalohippocampectomy
Creators: name: David, Bastian
name: Eberle, Jasmine
name: Delev, Daniel
name: Gaubatz, Jennifer
name: Prillwitz, Conrad C.
name: Wagner, Jan
name: Schoene-Bake, Jan-Christoph
name: Luechters, Guido
name: Radbruch, Alexander
name: Wabbels, Bettina
name: Schramm, Johannes
name: Weber, Bernd
name: Surges, Rainer
name: Elger, Christian E.
name: Rüber, Theodor
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Brain imaging
subject: Epilepsy
subject: Magnetic resonance imaging
subject: Neurosurgery
subject: Translational research
subject: TEMPORAL-LOBE RESECTION
subject: OPTIC RADIATION
subject: DIFFUSION MRI
subject: MEYERS LOOP
subject: EPILEPSY
subject: TRACTOGRAPHY
subject: BRAIN
subject: DEFICITS
subject: SURGERY
subject: VISION
subject: DDC 610 / Medicine & health

description: Abstract Selective amygdalohippocampectomy is an effective treatment for patients with therapy-refractory temporal lobe epilepsy but may cause visual field defect (VFD). Here, we aimed to describe tissue-specific pre- and postoperative imaging correlates of the VFD severity using whole-brain analyses from voxel- to network-level. Twenty-eight patients with temporal lobe epilepsy underwent pre- and postoperative MRI (T1-MPRAGE and Diffusion Tensor Imaging) as well as kinetic perimetry according to Goldmann standard. We probed for whole-brain gray matter (GM) and white matter (WM) correlates of VFD using voxel-based morphometry and tract-based spatial statistics, respectively. We furthermore reconstructed individual structural connectomes and conducted local and global network analyses. Two clusters in the bihemispheric middle temporal gyri indicated a postsurgical GM volume decrease with increasing VFD severity (FWE-corrected p < 0.05). A single WM cluster showed a fractional anisotropy decrease with increasing severity of VFD in the ipsilesional optic radiation (FWE-corrected p < 0.05). Furthermore, patients with (vs. without) VFD showed a higher number of postoperative local connectivity changes. Neither in the GM, WM, nor in network metrics we found preoperative correlates of VFD severity. Still, in an explorative analysis, an artificial neural network meta-classifier could predict the occurrence of VFD based on presurgical connectomes above chance level.
title: Instability Resistance Training improves Working Memory, Processing Speed and Response Inhibition in Healthy Older Adults: A Double-Blinded Randomised Controlled Trial
Creators: name: Eckardt, Nils
name: Braun, Claudia
name: Kibele, Armin
Publisher: name: Universität Kassel
Year: 2020
Subjects: subject: 796

description: Gefördert durch den Publikationsfonds der Universität Kassel
Additional file 1 of Consequences of rare diagnoses for education and daily life: development of an observation instrument
Creators: name: Jaeger, Gunilla
name: Röjvik, AnnCatrin
name: Hjelmquist, Erland
name: Hansla, André
name: Falkman, Kerstin W.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 1. The Ågrenska observation instrument.
Additional file 2 of Consequences of rare diagnoses for education and daily life: development of an observation instrument
Creators: name: Jaeger, Gunilla
name: Röjvik, AnnCatrin
name: Hjelmquist, Erland
name: Hansla, André
name: Falkman, Kerstin W.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 2. Changes in the observation instrument.
The spinners and weavers of Swarthmoor Hall, Ulverston, in the late 17th century.
Creators: name: Pidcock, Barbara
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 95, 153-168
description: Historical records of weavers and spinners, whose numbers do not always tally with the number of wheels etc recorded, casting doubt on the often assumed equation between the number of workers in an industry and the volume of machinery.
Rebuilding the Medieval Court-House at Keswick in 1571.
Creators: name: Tyson, Blake
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 95, 119-136
description: Presents documentary evidence on the construction of the civic building, including an appendix `Transcription of Richard Dudley's 1571 copper account' (132--3).
Human impact on vegetation in northern Cumbria since the Bronze Age: relating palynological and archaeological evidence.
Creators: name: Dumayne-Peaty, Lisa
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 95, 23-34
description: Presents palynological evidence with particular reference to the IA/RB period, from three large mire sites. The regional radiocarbon-dated pollen diagrams are discussed in relation to the archaeological record, and the problems associated with comparing the two data types are examined.
Prehistoric habitation of the Cumbrian limestone uplands: occupation sites found between 1986 and 1993.
Creators: name: Cherry, James
name: Cherry, Peter J
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 95, 1-22
description: Records sites isolated during the period, along with specialist reports in the form of appendix one `Petrological notes on further lithic fragments from the Cumbrian limestone uplands' by R V Davis (14--16), appendix two `Pottery from eastern Cumbria 1987--1993' by T G Manby (16--19), and appendix three `Pollen analysis from wet Sleddale' by S J Chinn & J B Innes (19--22).
A biomechanical comparison of a cement-augmented odontoid screw with a posterior-instrumented fusion in geriatric patients with an odontoid fracture type IIb
Creators: name: Schwarz, Falko
name: Liebsch, Christian
name: Berger-Roscher, Nikolaus
name: Wilke, Hans-Joachim
name: Sakr, Yasser
name: Kalff, Rolf
name: Waschke, Albrecht
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Odontoid screw
subject: Cement augmented
subject: Odontoid fracture
subject: Biomechanical
subject: Elderly
subject: DDC 610 / Medicine & health

description: Abstract Purpose Possible surgical therapies for odontoid fracture type IIb include odontoid screw osteosynthesis (OG) with preservation of mobility or dorsal C1/2 fusion with restriction of cervical rotation. In order to reduce material loosening in odontoid screw osteosynthesis in patients with low bone density, augmentation at the base of the axis using bone cement has been established as a suitable alternative. In this study, we compared cement-augmented OG and C1/2 fusion according to Harms (HG). Methods Body donor preparations of the 1st and 2nd cervical vertebrae were randomized in 2 groups (OG vs. HG). The range of motion (ROM) was determined in 3 principle motion plains. Subsequently, a cyclic loading test was performed. The decrease in height of the specimen and the double amplitude height were determined as absolute values as an indication of screw loosening. Afterward, the ROM was determined again and loosening of the screws was measured in a computed tomography. Results A total of 16 were included. Two groups of 8 specimens (OG vs. HG) from patients with a median age of 80 (interquartile range (IQ) 73.5–85) years and a reduced bone density of 87.2 (IQ 71.2–104.5) mg/cc dipotassium hydrogen phosphate were examined for their biomechanical properties. Before and after exposure, the OG preparations were significantly more mobile. At the time of loading, the OG had similar loading properties to HG decrease in height of the specimen and the double amplitude height. Computed tomography revealed similar outcomes with regard to the screw loosening rate (62.5 vs. 87.5%, p = 0.586). Conclusion In patients with an odontoid fracture type IIb and reduced bone density, cement-augmented odontoid screw yielded similar properties in the loading tests compared to the HG. It may, therefore, be considered as a primary alternative to preserve cervical mobility in these patients.
RCVS: by clinicians for clinicians : a narrative review
Creators: name: Erhart, Deborah Katharina
name: Ludolph, Albert C.
name: Althaus, Katharina
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Reversible cerebral vasoconstriction syndrome
subject: Posterior reversible encephalopathy syndrome
subject: Thunderclap headache
subject: Primary angiitis of the central nervous system
subject: DDC 610 / Medicine & health
subject: Stroke; Physiopathology
subject: Central nervous system; Physiopathology
subject: Vasoconstriction
subject: Headache
subject: Schlaganfall
subject: Vasokonstriktion
subject: Kopfschmerz

description: Background/Objective Reversible cerebral vasoconstriction syndrome may be underdiagnosed. It can be accompanied by various complications, mainly intracerebral hemorrhage and ischemic stroke. The clinical presentation of this condition varies according to its localization. The aims of this review are to raise awareness of the disease, especially in the presence of corresponding risk factors; to connect its precipitating factors, pathophysiology, and complications; and to compare various differential diagnoses of vasoconstriction. Methods A review of the literature in PubMed/MEDLINE and Google Scholar was conducted from May 1997 until May 2022. Results Reversible cerebral vasoconstriction syndrome, which is a clinical–radiological syndrome, is mainly characterized by the occurrence of thunderclap headache and widespread vasoconstriction. The most common precipitating factors are the use of vasoactive substances and postpartum status. The pathophysiology is currently assumed to include two mechanisms: sympathetic overactivity and endothelial dysfunction. From these mechanisms, it is possible to derive potential complications as well as the most important differential diagnoses: posterior reversible encephalopathy syndrome, convexity subarachnoid hemorrhage, ischemic and hemorrhagic stroke, and primary angiitis of the central nervous system. Conclusion In general, the outcome of reversible cerebral vasoconstriction syndrome is very good. Vasospasm as well as thunderclap headache attacks can be fully reversible, and > 90% of patients are functionally independent at discharge.
Additional file 3 of Consequences of rare diagnoses for education and daily life: development of an observation instrument
Creators: name: Jaeger, Gunilla
name: Röjvik, AnnCatrin
name: Hjelmquist, Erland
name: Hansla, André
name: Falkman, Kerstin W.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 3. Content validation.
Agiles Sprintlernen wirkt – aber warum? Theoriegeleitete Analyse der Wirkprinzipien eines Gestaltungsansatzes für arbeitsbezogene Kompetenzentwicklung
Creators: name: Jungclaus, Joana
name: Schaper, Niclas
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Agiles Sprintlernen
subject: Arbeitsbezogenes Lernen
subject: Agiles Lernen
subject: Programmevaluation
subject: Theoretische Fundierung
subject: Agile Sprintlearning
subject: Work-related learning
subject: Agile learning
subject: Theory-driven evaluation
subject: Theoretical foundation
subject: DDC 150 / Psychology
subject: Learning
subject: Lernen
subject: Lebenslanges Lernen

description: Dieser Beitrag der Zeitschrift Gruppe. Interaktion. Organisation. (GIO) stellt eine theoriegeleitete Analyse der Wirkprinzipien des Agilen Sprintlernens vor. Agiles Sprintlernen ist ein neuartiger Gestaltungsansatz für arbeitsbezogene Kompetenzentwicklung. Die bisherige Forschung zeigt positive Ergebnisse hinsichtlich des erfolgreichen Kompetenzerwerbs, der Zufriedenheit mit dem Lernerfolg sowie der Bewertung und Akzeptanz der Lernform. Bislang wurde jedoch nicht durchgängig untersucht, wie und warum das agile Sprintlernen wirksam ist. Dem methodischen Ansatz der Programmevaluation folgend, wird analysiert, welche lerntheoretischen Konstrukte den Gestaltungsansatz im Besonderen kennzeichnen und inwieweit diese die Wirkweise des agilen Sprintlernens erklären können. Die Ergebnisse zeigen, dass das agile Sprintlernen durch neun zentrale Gestaltungs- und Wirkungselemente gekennzeichnet ist: Zielorientierung und Zielverfolgung, Transparenz und Klarheit, Planung des Lernens, Eigenaktivität und Eigenverantwortung, Feedback, Selbstreflexion, Autonomie, Kompetenzerleben und soziale Eingebundenheit. Zur theoretischen Fundierung und Herleitung potenzieller Wirkmechanismen im agilen Sprintlernen werden mehrere lerntheoretische Bezugspunkte herangezogen – u. a. die Zielsetzungstheorie und die Theorie der sozialen Interdependenz. Die Ergebnisse werden abschließend diskutiert.
Additional file 4 of Consequences of rare diagnoses for education and daily life: development of an observation instrument
Creators: name: Jaeger, Gunilla
name: Röjvik, AnnCatrin
name: Hjelmquist, Erland
name: Hansla, André
name: Falkman, Kerstin W.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 4. Descriptive statistics.
Noninvasive, longitudinal imaging-based analysis of body adipose tissue and water composition in a melanoma mouse model and in immune checkpoint inhibitor-treated metastatic melanoma patients
Creators: name: Thaiss, Wolfgang M.
name: Gatidis, Sergios
name: Sartorius, Tina
name: Machann, Jürgen
name: Peter, Andreas
name: Eigentler, Thomas K.
name: Nikolaou, Konstantin
name: Pichler, Bernd J.
name: Kneilling, Manfred
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Melanoma
subject: Cancer cachexia
subject: MRI
subject: Segmentation
subject: Therapy monitoring
subject: Immune checkpoint inhibitor therapy
subject: DDC 610 / Medicine & health

description: Abstract Background As cancer cachexia (CC) is associated with cancer progression, early identification would be beneficial. The aim of this study was to establish a workflow for automated MRI-based segmentation of visceral (VAT) and subcutaneous adipose tissue (SCAT) and lean tissue water (LTW) in a B16 melanoma animal model, monitor diseases progression and transfer the protocol to human melanoma patients for therapy assessment. Methods For in vivo monitoring of CC B16 melanoma-bearing and healthy mice underwent longitudinal three-point DIXON MRI (days 3, 12, 17 after subcutaneous tumor inoculation). In a prospective clinical study, 18 metastatic melanoma patients underwent MRI before, 2 and 12 weeks after onset of checkpoint inhibitor therapy (CIT; n = 16). We employed an in-house MATLAB script for automated whole-body segmentation for detection of VAT, SCAT and LTW. Results B16 mice exhibited a CC phenotype and developed a reduced VAT volume compared to baseline (B16 − 249.8 µl, − 25%; controls + 85.3 µl, + 10%, p = 0.003) and to healthy controls. LTW was increased in controls compared to melanoma mice. Five melanoma patients responded to CIT, 7 progressed, and 6 displayed a mixed response. Responding patients exhibited a very limited variability in VAT and SCAT in contrast to others. Interestingly, the LTW was decreased in CIT responding patients (− 3.02% ± 2.67%; p = 0.0034) but increased in patients with progressive disease (+ 1.97% ± 2.19%) and mixed response (+ 4.59% ± 3.71%). Conclusion MRI-based segmentation of fat and water contents adds essential additional information for monitoring the development of CC in mice and metastatic melanoma patients during CIT or other treatment approaches.
Additional file 5 of Consequences of rare diagnoses for education and daily life: development of an observation instrument
Creators: name: Jaeger, Gunilla
name: Röjvik, AnnCatrin
name: Hjelmquist, Erland
name: Hansla, André
name: Falkman, Kerstin W.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 5. Interrater reliability.
Liquid-liquid centrifugal extractors: types and recent applications – a review
Creators: name: Hamamah, Zaid Alkhier
name: Grützner, Thomas
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Annular Centrifugal Contactors
subject: Centrifugal extractors
subject: Process Intensification
subject: Rotary devices
subject: DDC 540 / Chemistry & allied sciences
subject: Extraction (Chemistry)
subject: Extraktion

description: In light of the elevating pressures toward adopting intensifying technologies, centrifugal extractors are increasingly drawing attention as a promising alternative to traditional extraction equipment. Recently, many fields have applied them in research and that resulted in a considerable amount of information that may be hard to follow. To keep interested researchers updated, this work presents the state-of-the-art status of those devices. That is, the different types of centrifugal extractors are first surveyed with emphasis on those available on the market nowadays. Then, their recent applications are covered with exclusion of two fields: oil-water separations and nuclear industry, as the purpose is to accent centrifugal extractors' potential and compatibility with the widest possible range of applications beyond traditional ones. A further section addresses the hydrodynamics of annular centrifugal contactors that form a major subfamily of centrifugal extractors. Those annular variants have received special focus throughout this work, since not only are they the most encountered devices in literature but also still to date under development with latest versions being 3D-printed.
Towards green 3D-microfabrication of Bio-MEMS devices using ADEX dry film photoresists
Creators: name: Roos, Michael M.
name: Winkler, Andreas
name: Nilsen, Madeleine
name: Menzel, Sigfried B.
name: Strehle, Steffen
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Dry film photoresist
subject: 3D Microfabrication
subject: Microcantilevers
subject: Microprobes
subject: DDC 570 / Life sciences
subject: DDC 620 / Engineering & allied operations
subject: Lithography
subject: Lithografie
subject: Lab on a Chip
subject: Mikrosonde

description: Current trends in miniaturized diagnostics indicate an increasing demand for large quantities of mobile devices for health monitoring and point-of-care diagnostics. This comes along with a need for rapid but preferably also green microfabrication. Dry film photoresists (DFPs) promise low-cost and greener microfabrication and can partly or fully replace conventional silicon-technologies being associated with high-energy demands and the intense use of toxic and climate-active chemicals. Due to their mechanical stability and superior film thickness homogeneity, DFPs outperform conventional spin-on photoresists, such as SU-8, especially when three-dimensional architectures are required for micro-analytical devices (e.g. microfluidics). In this study, we utilize the commercial epoxy-based DFP ADEX to demonstrate various application scenarios ranging from the direct modification of microcantilever beams via the assembly of microfluidic channels to lamination-free patterning of DFPs, which employs the DFP directly as a substrate material. Finally, kinked, bottom-up grown silicon nanowires were integrated in this manner as prospective ion-sensitive field-effect transistors in a bio-probe architecture directly on ADEX substrates. Hence, we have developed the required set of microfabrication protocols for such an assembly comprising metal thin film deposition, direct burn-in of lithography alignment markers, and polymer patterning on top of the DFP.
Mountain Ecology, Remoteness, and the Rise of Agrobiodiversity: Tracing the Geographic Spaces of Human–Environment Knowledge
Creators: name: Zimmerer, Karl S.
name: Hildegardo Córdova-Aguilar
name: Olmo, Rafael Mata
name: Olivencia, Yolanda Jiménez
name: Vanek, Steven J.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: We use an original geographic framework and insights from science, technology, and society studies and the geohumanities to investigate the development of global environmental knowledge in tropical mountains. Our analysis demonstrates the significant relationship between current agrobiodiversity and the elevation of mountain agroecosystems across multiple countries. We use the results of this general statistical model to support our focus on mountain agrobiodiversity. Regimes of the agrobiodiversity knowledge of scientists, government officials, travelers, and indigenous peoples, among others, interacting in mountain landscapes have varied significantly in denoting geographic remoteness. Knowledge representing pre-European mountain geography and diverse food plants in the tropical Andes highlighted their centrality to the Inca Empire (circa 1400–1532). The notion of semiremoteness, geographic valley–upland differentiation, and the similitude-and-difference knowledge mode characterized early Spanish imperial rule (1532–1770). Early modern accounts (1770–1900) amplified the remoteness of the Andes as they advanced global ecological sciences, knowledge standardization, and racial representations of indigenous people as degraded, with scant attention to Andean agriculture and food. Global agrobiodiversity knowledge increasingly drew on corresponding representations of mountain remoteness. Our integration of the biogeophysical–social sciences with the geohumanities reveals distinctive geographies of agrobiodiversity knowledge. Assumed remoteness of mountain agrobiodiversity is not inherent but rather is actively formed in relation to global societies and knowledge systems and is thus relational. Connectivity and claims to territorial and indigenous autonomy distinguish newly emergent characteristics of agrobiodiversity. The multifunctionality and political geography of agrobiodiversity are integral to current mountain environments, societies, and sustainability.
A watching brief at 46-52 Lowther Street, Carlisle.
Creators: name: Flynn, Paul
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 94, 289-291
description: A section of metalled road surface, RB pottery, pits, and cobbles were observed. There were plough marks dating to before the road's construction.
PEDAGOGICAL AND PSYCHOLOGICAL CHARACTERISTICS OF TEACHER'S PROFESSIONAL TRAINING AND THE RESULTING PEDAGOGICAL COMMUNICATION THAT AFFECTS THE DEVELOPMENT OF STUDENTS' PROFESSIONAL THINKING
Creators: name: Kurbanova, Gulnoz
Publisher: name: Zenodo
Year: 2024

description: The given article reveals the importance of the teacher's professional development in the implementation of the pedagogical and psychological features of the teacher's professional training and development today, as well as the extremely important role of professional thinking in the teacher's communication. In addition, the research highlights the importance of developing students' professional thinking through pedagogical communication, as well as the extremely important role of professional thinking in patient-physician communication, particularly, among students of higher educational medical institutions.
title: OFROM: interview avec unine15a88m
Creators: name: Delafontaine, François
name: Rothenbühler, Julie
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.d6c27zfl.v2#1249d498de10fca3fcdb94b2d491ef9db4bf32cb
Additional file 6 of Consequences of rare diagnoses for education and daily life: development of an observation instrument
Creators: name: Jaeger, Gunilla
name: Röjvik, AnnCatrin
name: Hjelmquist, Erland
name: Hansla, André
name: Falkman, Kerstin W.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 6. Multinomial regression analysis.
Qubit-based momentum measurement of a particle
Creators: name: Konrad, Bernd
name: Di Pumpo, Fabio
name: Freyberger, Matthias
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: QUANTUM
subject: DDC 530 / Physics
subject: Pointers
subject: Time of Arrival

description: An early approach to include pointers representing measurement devices into quantum mechanics was given by von Neumann. Based on this idea, we model such pointers by qubits and couple them to a free particle, in analogy to a classical time-of-flight arrangement. The corresponding Heisenberg dynamics leads to pointer observables whose expectation values allow us to reconstruct the particle’s momentum distribution via the characteristic function. We investigate different initial qubit states and find that such a reconstruction can be considerably simplified by initially entangled pointers.
Additional file 7 of Consequences of rare diagnoses for education and daily life: development of an observation instrument
Creators: name: Jaeger, Gunilla
name: Röjvik, AnnCatrin
name: Hjelmquist, Erland
name: Hansla, André
name: Falkman, Kerstin W.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 7. Summary of contributions of the domains.
Determinants in the place of death for people with different cancer types: a national population-based study
Creators: name: Öhlén, Joakim
name: Cohen, Joachim
name: Håkanson, Cecilia
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Cancer

description: Background: Place of death has for the past decade increasingly come to be regarded as a robust indicator of how palliative care is organized and provided, and is also recognized as an important factor for well being at the end of life. Variations in place of cancer deaths have previously been reported in the context of country-specific healthcare organization, but without differentiating between cancer types and national regional variations. Our aim was to examine, at a population level, where people with cancer diseases die in Sweden, and to investigate associations of place of death and cancer type with individual, socioeconomic and geographical characteristics of the deceased. Material and methods: This population level study is based on death certificate data (sex; age; underlying cause of death and place of death) and population register data (educational attainment, marital status, living arrangements, area of residence, degree of urbanization, and healthcare region) of all 2012 cancer deaths in Sweden, with a registered place of death (hospital, nursing home, home, other places). Data were explored descriptively. To investigate associations between place of death and cancer types, and individual, socioeconomic and environmental characteristics, a series of multivariable logistic regression analyses were performed. Results: The most frequent type of cancer death occurring at home was upper gastrointestinal cancer (25.6%) and the least frequent was hematological cancer (15.2%). Regional variations in cancer deaths occurring at home ranged from 17.1% to 28.4%. Factors associated with place of death by cancer type were age, educational attainment, marital status, healthcare regions and degree of urbanization. Conclusion: Large healthcare regional variations in place of death among different cancer types were found. The socioeconomic inequality previously demonstrated for screening, diagnostic and treatment processes, rehabilitation and survival thus also seems to be reflected in the place of death.
Is there a role for statistics in artificial intelligence?
Creators: name: Friedrich, Sarah
name: Antes, Gerd
name: Behr, Sigrid
name: Binder, Harald
name: Brannath, Werner
name: Dumpert, Florian
name: Ickstadt, Katja
name: Kestler, Hans A.
name: Lederer, Johannes
name: Leitgöb, Heinz
name: Pauly, Markus
name: Steland, Ansgar
name: Wilhelm, Adalbert
name: Friede, Tim
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: CAUSAL INFERENCE
subject: LEARNING ALGORITHM
subject: MODELS
subject: SELECTION
subject: VALIDITY
subject: DDC 510 / Mathematics
subject: Statistics
subject: FOS: Mathematics
subject: Artificial intelligence
subject: Machine learning
subject: Neural networks (Computer science)
subject: Science
subject: Statistik
subject: Künstliche Intelligenz
subject: Maschinelles Lernen
subject: Data Science
subject: Big Data
subject: Neuronales Netz
subject: Design
subject: Auslese
subject: Scale

description: Abstract The research on and application of artificial intelligence (AI) has triggered a comprehensive scientific, economic, social and political discussion. Here we argue that statistics, as an interdisciplinary scientific field, plays a substantial role both for the theoretical and practical understanding of AI and for its future development. Statistics might even be considered a core element of AI. With its specialist knowledge of data evaluation, starting with the precise formulation of the research question and passing through a study design stage on to analysis and interpretation of the results, statistics is a natural partner for other disciplines in teaching, research and practice. This paper aims at highlighting the relevance of statistical methodology in the context of AI development. In particular, we discuss contributions of statistics to the field of artificial intelligence concerning methodological development, planning and design of studies, assessment of data quality and data collection, differentiation of causality and associations and assessment of uncertainty in results. Moreover, the paper also discusses the equally necessary and meaningful extensions of curricula in schools and universities to integrate statistical aspects into AI teaching.
Metabolic syndrome and the plasma proteome: from association to causation
Creators: name: Elhadad, Mohamed A.
name: Wilson, Rory
name: Zaghlool, Shaza B.
name: Huth, Cornelia
name: Gieger, Christian
name: Grallert, Harald
name: Graumann, Johannes
name: Rathmann, Wolfgang
name: Koenig, Wolfgang
name: Sinner, Moritz F.
name: Hveem, Kristian
name: Suhre, Karsten
name: Thorand, Barbara
name: Jonasson, Christian
name: Waldenberger, Melanie
name: Peters, Annette
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Metabolic syndrome
subject: Proteomics
subject: Blood proteins
subject: Mendelian randomization analysis
subject: Diabetes mellitus
subject: type 2
subject: Cardiovascular disease
subject: Risk factors
subject: MENDELIAN RANDOMIZATION
subject: RISK
subject: OBESITY
subject: ENDOCAN
subject: RAGE
subject: MICE
subject: DDC 610 / Medicine & health

description: Abstract Background The metabolic syndrome (MetS), defined by the simultaneous clustering of cardio-metabolic risk factors, is a significant worldwide public health burden with an estimated 25% prevalence worldwide. The pathogenesis of MetS is not entirely clear and the use of molecular level data could help uncover common pathogenic pathways behind the observed clustering. Methods Using a highly multiplexed aptamer-based affinity proteomics platform, we examined associations between plasma proteins and prevalent and incident MetS in the KORA cohort (n = 998) and replicated our results for prevalent MetS in the HUNT3 study (n = 923). We applied logistic regression models adjusted for age, sex, smoking status, and physical activity. We used the bootstrap ranking algorithm of least absolute shrinkage and selection operator (LASSO) to select a predictive model from the incident MetS associated proteins and used area under the curve (AUC) to assess its performance. Finally, we investigated the causal effect of the replicated proteins on MetS using two-sample Mendelian randomization. Results Prevalent MetS was associated with 116 proteins, of which 53 replicated in HUNT. These included previously reported proteins like leptin, and new proteins like NTR domain-containing protein 2 and endoplasmic reticulum protein 29. Incident MetS was associated with 14 proteins in KORA, of which 13 overlap the prevalent MetS associated proteins with soluble advanced glycosylation end product-specific receptor (sRAGE) being unique to incident MetS. The LASSO selected an eight-protein predictive model with an (AUC = 0.75; 95% CI = 0.71–0.79) in KORA. Mendelian randomization suggested causal effects of three proteins on MetS, namely apolipoprotein E2 (APOE2) (Wald-Ratio = − 0.12, Wald-p = 3.63e−13), apolipoprotein B (APOB) (Wald-Ratio = − 0.09, Wald-p = 2.54e−04) and proto-oncogene tyrosine-protein kinase receptor (RET) (Wald-Ratio = 0.10, Wald-p = 5.40e−04). Conclusions Our findings offer new insights into the plasma proteome underlying MetS and identify new protein associations. We reveal possible casual effects of APOE2, APOB and RET on MetS. Our results highlight protein candidates that could potentially serve as targets for prevention and therapy.
Exploring the full potential of photocatalytic carbon dioxide reduction using a dinuclear Re2Cl2 complex assisted by various phhotosensitizers
Creators: name: Giereth, Robin
name: Obermeier, Martin
name: Forschner, Lukas
name: Karnahl, Michael
name: Schwalbe, Matthias
name: Tschierlei, Stefanie
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: bimetallic activation
subject: carbon dioxide reduction
subject: cooperative effects
subject: DDC 540 / Chemistry & allied sciences
subject: Photocatalysis
subject: Rhenium
subject: Kooperativität
subject: Fotokatalyse

description: Good cooperation: The full potential of a xanthene-bridged homodinuclear rhenium(I) complex (Re2Cl2) for the light-driven reduction of CO2 to CO is enabled by addition of iridium(III) or copper(I) photosensitizers. The Re2Cl2 catalyst with two singly-reduced rhenium moieties is generated through photocatalytic induced potent reductants. This in turn enables bimetallic activation of CO2 and leads to an increase in catalytic activity. Photosensitizing units have already been applied to enable light-driven catalytic reduction of CO2 with mononuclear rhenium complexes. However, dinuclear catalytic systems that are able to activate CO2 in a cooperative bimetallic fashion have only rarely been combined with photosensitizers. We here present detailed studies on the influence of additional photosensitizers on the catalytic performance of a dirhenium complex (Re2Cl2) and present correlations with spectroscopic measurements, which shed light on the reaction mechanism. The use of [Ir(dFppy)3] (Ir, dFppy=2-(4,6-difluorophenyl)pyridine)) resulted in considerably faster CO2 to CO transformation than [Cu(xant)(bcp)]PF6 (Cu, xant=xantphos, bcp=bathocuproine). Emission quenching studies, transient absorption as well as IR spectroscopy provide information about the electron transfer paths of the intermolecular systems. It turned out that formation of double reduced species [Re2Cl2]2− along with an intermediate with a Re−Re bond ([ReRe]) can be taken as an indication of multi-electron storage capacity. Furthermore, under catalytic conditions a CO2-bridged intermediate was identified.
Spacial structures induced by sterical hindrance of large substituents : a dendritic macromolecular “snowflake” molecule
Creators: name: Leitner, Tanja D.
name: Mena-Osteritz, Elena
name: Bäuerle, Peter
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: denrdrimer
subject: quantum chemical calculation
subject: thienylene-phenylene
subject: DDC 540 / Chemistry & allied sciences
subject: Atomic force microscopy
subject: Quantum chemistry
subject: Rasterkraftmikroskopie
subject: Thienylethene

description: The mulitstage preparation of densly packed thienylene-phenylene dendrimer 15 comprising 42 thiophene and 7 benzene units arranged in a hexagonal “snowflake” fashion is described. The desired three-dimensionality is induced through steric repulsion of the peripheral hexa(thienyl)benzene units. The molecular geometry of individual dendrimers was supported by quantum chemical calculations, whereby atomic force microscopy gave evidence for spontaneous ordering of the molecules on a graphite surface by the formation of stable nanosized edge-on oriented columns.