cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Synthesis of novel sulfonamides under mild conditions with effective inhibitory activity against the carbonic anhydrase isoforms I and II
Creators: name: Başar, Erhan
name: Tunca, Ekrem
name: Bülbül, Metin
name: Kaya, Muharrem
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 60506 Virology

description: Novel sulfonamide derivatives 6a–i, as new carbonic anhydrase inhibitors which candidate for glaucoma treatment, were synthesized from the reactions of 4-amino-N-(4-sulfamoylphenyl) benzamide 4 and sulfonyl chloride derivatives 5a–i with high yield (71–90%). The structures of these compounds were confirmed by using spectral analysis (FT-IR, 1H NMR, 13C NMR, LC/MS and HRMS). The inhibition effects of 6a–i on the hydratase and esterase activities of human carbonic anhydrase isoenzymes, hCA I and II, which were purified from human erythrocytes with Sepharose®4B-l-tyrosine-p-aminobenzene sulfonamide affinity chromatography, were studied as in vitro, and IC50 and Ki values were determined. The results show that newly synthesized compounds have quite powerful inhibitory properties.
Discrimination of bacteriophage infected cells using locked nucleic acid fluorescent in situ hybridization (LNA-FISH)
Creators: name: Boas, Diana Vilas
name: Almeida, Carina
name: Sillankorva, Sanna
name: Nicolau, Ana
name: Azeredo, Joana
name: Azevedo, Nuno F.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Bacteriophage–host interaction studies in biofilm structures are still challenging due to the technical limitations of traditional methods. The aim of this study was to provide a direct fluorescence in situ hybridization (FISH) method based on locked nucleic acid (LNA) probes, which targets the phage replication phase, allowing the study of population dynamics during infection. Bacteriophages specific for two biofilm-forming bacteria, Pseudomonas aeruginosa and Acinetobacter, were selected. Four LNA probes were designed and optimized for phage-specific detection and for bacterial counterstaining. To validate the method, LNA-FISH counts were compared with the traditional plaque forming unit (PFU) technique. To visualize the progression of phage infection within a biofilm, colony-biofilms were formed and infected with bacteriophages. A good correlation (r = 0.707) was observed between LNA-FISH and PFU techniques. In biofilm structures, LNA-FISH provided a good discrimination of the infected cells and also allowed the assessment of the spatial distribution of infected and non-infected populations.
title: PAC-Australia (2023): Recording with BB, word list n°2
title: 2019 - post PSS2
titleType: AlternativeTitle
Creators: name: Mas, Erwanne
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Australian English
subject: eng

description: PAC word list n°2
description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
Assessment practices of Irish speech and language therapists in the evaluation of voice disorders
Creators: name: Ciarán Kenny
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: It is commonly accepted that the evaluation of voice disorders ought to include extensive perceptual, psychometric, and instrumental measurements. This serves to encapsulate the wide-reaching effects of such a disorder, from the physical impairment in voice production to the psycho-social impact of having a dysphonic voice. In spite of this, no international gold standard exists by which voice disorders should be evaluated, and so speech and language therapists (SLTs) are often tasked with developing an assessment battery for use in their own clinics. The purpose of this study is to determine whether the evaluation of voice disorders by Irish SLTs on a national scale is suitably comprehensive, with particular reference to the guidelines published by the European Laryngological Society. A total of 49 SLTs working in a variety of settings responded anonymously to an electronic survey regarding their assessment practices. Results indicate that therapists are comprehensive in non-instrumental evaluation of voice, but lack both access to and training in instrumental assessment techniques.
Cooperativity of tetrel bonds tuned by substituent effects
Creators: name: Esrafili, Mehdi D.
name: Mohammadian-Sabet, Fariba
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Substituent effects on cooperativity between N···X and C···X interactions are studied in the 4-Z-Py···XH3(NC)···XH3(NC) complexes, where X = C, Si; Z = H, F, OH, CH3, NH2, F, NC, CN, NO2 and Py = pyridine. All N···X and C···X binding distances in the ternary complexes are always shorter than those in the corresponding binary complex. This indicates that the formation of the N···X interaction strengthens C···X bond in these complexes and vice versa. Our results reveal that the strength of N···X and C···X interactions in the ternary complexes considerably depends on the nature of X and Z substituents. For a given aromatic system, the shortening of N···X and C···X distances is more important for SiH3(NC) complexes than CH3(NC) counterparts. The mechanism of cooperative effects in the ternary complexes is unveiled by electrostatic potential analyses and natural bond theory. The ELF representation (isosurface value= 0.75 au) of 4-HPy ···SiH3(NC)···SiH3(NC) complex.
Rising Wages Point to a Tighter Farm Labor Market in the United States
Creators: name: Zahniser, Steven
name: Taylor, J. Edward
name: Hertz, Thomas
name: Charlton, Diane
name: Zahniser, Steven
name: Taylor, J. Edward
name: Hertz, Thomas
name: Charlton, Diane
Publisher: name: Unknown
Year: 2019
Subjects: subject: Agricultural and Food Policy
subject: Farm Management
subject: Financial Economics
subject: Labor and Human Capital
subject: farm labor
subject: farm sector
subject: nonfarm wages
subject: farm wages

description: A recent ERS study found that labor supply in the farm sector may be tightening, evidenced by rising farm wages relative to the nonfarm wages and other factors.
PAC-Australia (2023): Recording with BB, "A Christmas interview"
Creators: name: Mas, Erwanne
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Australian English
subject: eng

description: PAC-LVTI Reading Task
description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
Assessment practices of Irish speech and language therapists in the evaluation of voice disorders
Creators: name: Ciarán Kenny
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: It is commonly accepted that the evaluation of voice disorders ought to include extensive perceptual, psychometric, and instrumental measurements. This serves to encapsulate the wide-reaching effects of such a disorder, from the physical impairment in voice production to the psycho-social impact of having a dysphonic voice. In spite of this, no international gold standard exists by which voice disorders should be evaluated, and so speech and language therapists (SLTs) are often tasked with developing an assessment battery for use in their own clinics. The purpose of this study is to determine whether the evaluation of voice disorders by Irish SLTs on a national scale is suitably comprehensive, with particular reference to the guidelines published by the European Laryngological Society. A total of 49 SLTs working in a variety of settings responded anonymously to an electronic survey regarding their assessment practices. Results indicate that therapists are comprehensive in non-instrumental evaluation of voice, but lack both access to and training in instrumental assessment techniques.
Homogeneous alignment of liquid crystals on low-temperature solution-derived gallium oxide films via IB irradiation method
Creators: name: Jang, Sang Bok
name: Gi-Seok Heo
name: Kim, Eun-Mi
name: Hong-Gyu Park
name: Lee, Ju Hwan
name: Jung, Yoon Ho
name: Hae-Chang Jeong
name: Jeong-Min Han
name: Dae-Shik Seo
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Neuroscience
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Computational Biology

description: In this paper, solution-derived gallium oxide (GaO) films are fabricated for the homogeneous alignment of liquid crystals (LCs) after an ion-beam (IB) irradiation process. GaO thin films are prepared under a variety of temperatures and different IB irradiation intensities, and the physicochemical performances of the fabricated GaO thin films are analysed using a UV-vis spectrometer, an atomic force microscope, and X-ray photoelectron spectroscopy. A higher transmittance of 85.40% from GaO thin film is obtained compared with that of polyimide (PI) film (83.52%), which indicates the feasibility for a GaO thin layer to substitute for a conventional PI layer as an alignment layer. LCs are found to align on the GaO thin film after pre-baking at 100°C and homogeneous and uniform low-IB intensity irradiation. We also determined the electro-optical (EO) characteristics of the twisted nematic (TN) cells fabricated with GaO thin layers and found them to be similar to those of cells fabricated with PI layers. Overall, GaO films achieved via the IB irradiation method are promising LC alignment layers due to the method’s low-temperature solution-derived process.
Meta-analysis of the COMT Val158Met polymorphism in major depressive disorder: the role of gender
Creators: name: Klein, Martina
name: Schmoeger, Michaela
name: Kasper, Siegfried
name: Schosser, Alexandra
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objectives: Many studies have reported an association of the COMT Val158Met polymorphism and major depressive disorder (MDD), although with conflicting results. The role of gender is a possible modulator. To overcome the problem of poor sample size detecting genes of small effect, we perform a meta-analysis of the current literature, investigating the influence of the COMT Val158Met polymorphism on the pathogenesis of MDD, with a major focus on the effect of gender. Methods: Out of 977 retrieved articles, 21 included case–control studies allowed the analysis of 9005 patients with MDD and 12,095 controls. Allelic and genotypic pooled odds ratios (OR) were calculated for the total sample and gender-subgroups. Results: In the absence of publication bias, allelic and genotypic analyses showed no significant association in the total sample, as well as in gender-specific subgroups. Sensitivity analysis did not alter the ORs. Conclusions: The results imply a complex nature of the genotype × phenotype interaction. Further studies of the COMT gene or the locus remain to be justified given the important positional and functional relevance and the plethora of gender-specific findings. A possible way to further dissect this topic is shifting the focus to gene-based or genome-wide analyses of intermediate phenotypes.
METH依赖与HDAC3的关系
Creators: name: 肖静(Xiao Jing)
Publisher: name: CNGB
Year: 2024
Subjects: Epigenomics
Variation
Multiisolate

description: METH成瘾与表观遗传学密切相关，其中HDAC3已有发现参与到成瘾的动物模型组，我们通过收集汉族人群中METH依赖的患者及其对照健康人，通过SNP的测序，发现5q31.3的rs14251与METH依赖密切相关。
Fragmentomic property of plasma cell-free DNA in critical COVID-19 patients
Creators: name: 李玲果(Li Lingguo)
Publisher: name: CNGB
Year: 2024
Subjects: Genome sequencing
Other
The BED (Browser Extensible Data) format is a text file format used to store genomic regions as coordinates and associated annotations.
cfDNA

description: Fragmentomic property of plasma cell-free DNA in critical COVID-19 patients
title: PAC-Australia (2023): Recording with BB, word list n°1
title: 2019 - post PSS2
titleType: AlternativeTitle
Creators: name: Mas, Erwanne
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Australian English
subject: eng

description: PAC word list n°1
description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
Sprachgeschichte(n)
Creators: name: Lasch, Alexander
Publisher: name: Zenodo
Year: 2023

description: In der Vorlesung wurden im Sommersemester 2022 zentrale Aspekte der Sprachgeschichte(n) des Deutschen in den Mittelpunkt gerückt. Ein besonderer Fokus lag auf der Integration aktueller digital gestützter Ressourcen wie Methoden sprachhistorischer Forschung zum einen in die Hochschullehre und zum anderen in den Deutschunterricht am Gymnasium. 

Bis in Basiswissen Sprachwissenschaft II eigene Module zur deutschen Sprachgeschichte angelegt sein werden, dient dieses Material zur Ergänzung von Basiswissen Sprachwissenschaft (Link).
Keratin 34betaE12/keratin7 expression is a prognostic factor of cancer-specific and overall survival in patients with early stage non-small cell lung cancer
Creators: name: Pøhl, Mette
name: Olsen, Karen Ege
name: Holst, Rene
name: Donnem, Tom
name: Lill-Tove Busund
name: Bremnes, Roy M.
name: Al-Saad, Samer
name: Sigve Andersen
name: Richardsen, Elin
name: Ditzel, Henrik J.
name: Olfred Hansen
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer

description: Background. Carcinomas and their metastases often retain the keratin patterns of their epithelial origin, and are therefore useful as lineage-specific markers in diagnostic pathology. Recently, it has become clear that intermediate filaments composed by keratins play a role in modulation of cell proliferation, migration, and possibly cancer invasion, factors impacting prognosis in early stage non-small cell lung cancer (NSCLC). Material and methods. Tumor tissue from a retrospective Danish cohort of 177 patients with completely resected NSCLC, stage I-IIIA tumors, were analyzed for keratin 7 (K7) and keratin 34βE12 expression by immunohistochemistry and validated in a comparable independent Norwegian cohort of 276 stage I-IIIA NSCLC patients. Results. Based on keratin 34βE12/K7 expression, three subgroups with significantly different median cancer-specific survival rates were identified (34βE12+/K7+, 168 months vs. 34βE12+/K7+, 73 months vs. 34βE12-/K7+, 30 months; p = 0.0004). In multivariate analysis, stage II-IIIA (HR 2.9), 34βE12+/K7+ (HR 1.90) and 34βE12-/K7+ (HR 3.7), were prognostic factors of poor cancer-specific survival (CSS) (p < 0.001). Validation in the Norwegian cohort confirmed that stage II-IIIA (HR 2.3), 34βE12+/K7+ (HR 1.6), and 34βE12-/K7+ (HR 2.0) were prognostic factors of poor CSS (p < 0.05). Multivariate Cox proportional-hazard analysis demonstrated that 34βE12+/K7 + and 34βE12+/K7 + status was significantly associated with poor overall survival (p < 0.05). Conclusion. Keratin 34βE12/K7 expression is a prognostic parameter in resected early stage NSCLC that allows identification of high-risk NSCLC patients with poor cancer-specific and overall survival.
Is 18F-FDG PET/CT an accurate tool for identifying metastases of lobular breast cancer?
Creators: name: Orevi, Marina
name: Freedman, Nanette
name: Tahover, Esther
name: Uziely, Beatrice
name: Chisin, Roland
name: Peretz, Tamar
name: Klein, Martine
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Plant Biology

description: Is 18F-FDG PET/CT an accurate tool for identifying metastases of lobular breast cancer?
Erdheim-Chester disease presenting as periodontal disease: Experience of treatment with cladribine, interferon-a, local radiotherapy and anakinra
Creators: name: Blomstrand, Lena
name: Thor, Andreas
name: Hagberg, Hans
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Erdheim-Chester disease presenting as periodontal disease: Experience of treatment with cladribine, interferon-a, local radiotherapy and anakinra
РАЗМЫШЛЕНИЯ О ПАТРИОТИЧЕСКОМ ВОСПИТАНИИ…
Creators: name: КУЛЕМИНА Людмила Борисовна
Publisher: name: Образование и право
Year: 2020
Subjects: патриотизм
национальная идея
Родина
Отечество

description: В статье рассматриваются вопросы, связанные с формированием патриотизма на Руси и в России в разные исторические периоды. Сформулированы задачи, стоящие перед обществом в деле патриотического воспитания на современном этапе.
ТЕЗИСЫ АКТУАЛЬНЫХ ПРОБЛЕМ НАЦИОНАЛЬНОГО ВОПРОСА СОВРЕМЕННОЙ РОССИИ
Creators: name: ПАРХОМЕНКО А. Г.
Publisher: name: Образование и право
Year: 2020
Subjects: национальный вопрос
Конституция
Президент
капитализм
закон
права человека.

description: Распад СССР привел к возникновению новых проблем, которые не имели аналогов в мировой практике, либо не существовали в столь широких масштабах, как это имеет место на постсоветском пространстве, и прежде всего связанные с этнофобией, русофобией, ксенофобией и т.п.
PAC-Australia (2018): Recording with SH, "A Christmas interview"
Creators: name: Mas, Erwanne
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Australian English
subject: eng

description: PAC-LVTI Reading Task
description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
СТРУКТУРА «ЗОНЫ ЗНАНИЙ» И РИСКИ В СОЦИОНОРМАТИВНОМ РЕГУЛИРОВАНИИ ИНСТИТУТОВ ГРАЖДАНСКОГО ОБЩЕСТВА В РАМКАХ ИНТЕГРАЦИОННЫХ ОБЪЕДИНЕНИЙ ГОСУДАРСТВ
Creators: name: ОРЛОВА Ольга Викторовна
Publisher: name: Образование и право
Year: 2020
Subjects: структура «зоны знаний»
гражданское общество
интеграционные объединения государств (ЕС и ЕАЭС)
соционормативное регулирование
риски правового регулирования.

description: В статье анализируется роль соционормативного регулирования структуры «зоны знаний» гражданского общества в России и странах ЕС и ЕАЭС. Автор раскрывает особености конкретных сфер функционирования гражданского общества в условиях интеграции, а также пытается определить риски соционормативного (в первую очередь правового) регулирования демократических институтов на примере России, ЕС. В работе содержится анализ действующего законодательства и высказываются конкретные предложения по его совершенствованию с целью минимизировать риски в интеграционных процессах, что позволит человеку накапливать и реализовывать правовые и иные знания, в т.ч. в сфере функционирования институтов гражданского общества.
Peer support and additional information in group medical consultations (GMCs) for BRCA1/2 mutation carriers: A randomized controlled trial
Creators: name: Visser, Annemiek
name: Laarhoven, Hanneke W. M. Van
name: Woldringh, Gwendolyn H.
name: Hoogerbrugge, Nicoline
name: Prins, Judith B.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Science Policy
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Background. Group medical consultations (GMCs) provide individual medical visits in the presence of ≤ 7 peer- patients. This study evaluated the efficacy of GMCs in the yearly breast cancer surveillance of BRCA mutation carriers. Material and methods. This randomized controlled trial compared GMCs (intervention group, n = 63) with individual medical visits (control group, n = 59). Between-group differences on the primary outcomes distress and empowerment, were analyzed one week and three months after the visit. Feasibility is evaluated in terms of demand, acceptability and practicability. Results. No between-group differences were found on primary outcomes. More themes were discussed in GMCs. Seventy-five percent of GMC-participants experienced peer support. Carriers reported significantly higher satisfaction with individual visits. GMCs were less time-efficient. Conclusion. This is the first GMC study which reports results in favor of individual visits. The hereditary nature of the condition differentiates our study population from earlier studied GMC groups. Even though most participants experienced peer support and received more information, the lower patient satisfaction may be explained by the lack of individual time with the clinician and disruption of normal surveillance routines. As the need for peer support and additional information is present in a substantial part of carriers, future research should study the process of peer support.
A novel oral insulin-like growth factor-1 receptor pathway modulator and its implications for patients with non-small cell lung carcinoma: A phase I clinical trial
Creators: name: Ekman, Simon
name: Harmenberg, Johan
name: Jan-Erik Frödin
name: Bergström, Stefan
name: Wassberg, Cecilia
name: Eksborg, Staffan
name: Larsson, Olle
name: Axelson, Magnus
name: Jerling, Markus
name: Abrahmsen, Lars
name: Hedlund, Åsa
name: Alvfors, Carina
name: Ståhl, Birgitta
name: Bergqvist, Michael
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Background. A phase Ia/b dose-escalation study was performed to characterize the safety, efﬁcacy and pharmacokinetic properties of the oral small molecule insulin-like growth factor-1-receptor pathway modulator AXL1717 in patients with advanced solid tumors. Material and methods. This was a prospective, single-armed, open label, dose-finding phase Ia/b study with the aim of single day dosing (phase Ia) to define the starting dose for multi-day dosing (phase Ib), and phase Ib to define and confirm recommended phase II dose (RP2D) and if possible maximum tolerated dose (MTD) for repeated dosing. Results and Conclusion. Phase Ia enrolled 16 patients and dose escalations up to 2900 mg BID were successfully performed without any dose limiting toxicity (DLT). A total of 39 patients were treated in phase Ib. AXL1717 was well tolerated with neutropenia as the only dose-related, reversible, DLT. RP2D dose was found to be 390 mg BID for four weeks. Some patients, mainly with NSCLC, demonstrated signs of clinical benefit, including four partial tumor responses (one according to RECIST and three according to PET). The 15 patients with NSCLC with treatment duration longer than two weeks with single agent AXL1717 in third or fourth line of therapy showed a median progression-free survival of 31 weeks and overall survival of 60 weeks. Down-regulation of IGF-1R on granulocytes and increases of free serum levels of IGF-1 were seen in patients treated with AXL1717. AXL1717 had an acceptable safety profile and demonstrated promising efficacy in this heavily pretreated patient cohort, especially in patients with NSCLC. RP2D was concluded to be 390 mg BID for four weeks. Trial number is NCT01062620.
ОПРЕДЕЛЕНИЕ БАЗОВЫХ КРИТЕРИЕВ ЭФФЕКТИВНОСТИ ПРАВОВОГО РЕГУЛИРОВАНИЯ ПРОТИВОДЕЙСТВИЯ ТЕРРОРИЗМУ НА МЕЖДУНАРОДНОМ УРОВНЕ
Creators: name: МАТЧАНОВА Зоя Шарифовна
Publisher: name: Образование и право
Year: 2020
Subjects: эффективность международно-правового регулирования
противодействие терроризму
темпоральные критерии
количественные критерии
качественные критерии
результативность
общественная безопасность
ресурсное обеспечение

description: В статье автор формулирует и раскрывает три группы критериев определения эффективности правового регулирования противодействия терроризму на международном уровне: темпоральные, количественные и качественные. Среди темпоральных критериев автор выделяет критерий скорости достижения результата и критерий устойчивости результата, отмечая, что каждый из них может быть раскрыт через три традиционных варианта: краткосрочность, среднесрочность и долгосрочность результата. Количественные критерии предполагают оценку того, насколько широким, масштабным, значительным является достигнутый результат, поэтому автор предлагает оценивать результативность по широте территориального охвата и по широте охвата объектов воздействия. В территориальном плане результативность может иметь универсальный, региональный, национальный охват, а оценка результативности по широте охвата объектов воздействия учитывает, был ли результат полезен всем, многим или только избранным категориям. Анализируя вопрос о качественных критериях эффективности правового регулирования противодействия терроризму на международном уровне, автор выделяет критерии достижения цели и выполнения поставленных антитеррористических задач, а также критерии правильности выбора стратегии и тактики, методов и средств противодействия.
ПОПРАВКИ 2020 ГОДА В КОНСТИТУЦИЮ РОССИЙСКОЙ ФЕДЕРАЦИИ. ВОПРОСЫ ОХРАНЫ ОКРУЖАЮЩЕЙ СРЕДЫ ЭКОЛОГИЧЕСКОЙ БЕЗОПАСНОСТИ, ЭКОЛОГИЧЕСКОГО ОБРАЗОВАНИЯ
Creators: name: ВИНОГРАДОВА Елена Валерьевна
Publisher: name: Образование и право
Year: 2020
Subjects: Поправки 2020 года в Конституцию; охрана природной среды
экологическая безопасность
экологическое образование
экологическая культура.

description: Конституционная реформа 2020 года, актуализировала интерес к вопросам охраны природной среды, экологической безопасности, экологического образования, экологической культуры. Предложение российского Президента о использовании потенциала Конституции, позволили внести ряд поправок в Основной закон, касающихся экологических проблем. Решение этих проблем, очевидно, потребует формирования новых подходов к вопросам теоретического обоснования правового регулирования в сфере экологии, основанного на конституционно-обозначенных приоритетах современного российского государства.
PAC-Australia (2018): Recording with DS, word list n°2
Creators: name: Mas, Erwanne
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Australian English
subject: eng

description: PAC word list n°2
description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
АНАЛИЗ ИНТЕРНЕТ-СООБЩЕСТВ ЛЮДЕЙ С ОГРАНИЧЕННЫМИ ВОЗМОЖНОСТЯМИ ПО ЗРЕНИЮ (НА ПРИМЕРЕ СОЦИАЛЬНОЙ СЕТИ ВКОНТАКТЕ)
Creators: name: ГОНЧАРОВА Инна Владимировна
name: ПРОНЧЕВ Геннадий Борисович
name: ПРОНЧЕВА Надежда Геннадьевна
Publisher: name: Образование и право
Year: 2020
Subjects: зрение
люди с ограниченными возможностями по зрению
Интернет-сообщества
социальные сети
ВКонтакте

description: В статье рассматриваются вопросы, связанные с анализом содержания Интернет-сообществ людей с ограниченными возможностями по зрению. В социальной сети ВКонтакте проведен поиск и исследование действующих Интернет-сообществ людей с ограниченными возможностями по зрению. С помощью сервиса аналитики постов и страниц в социальных сетях Posters проанализировано содержания этих сообществ, выявлены наиболее актуальные темы для данной категории граждан. Наибольшее количество пользователей зарегистрировано в сообществах, заполнением контента которого занимаются сами пользователи. Тематика постов этих Интернет-сообществ разнообразна. Наибольший отклик пользователей приходится на посты, утверждающие традиционные жизненные принципы: сострадание, помощь, преодоление трудностей. Материалы статьи представляют практическую ценность для специалистов, занимающихся проблемами социализации и социальной адаптации людей с ограниченными возможностями по зрению.
ФОРМЫ РЕАЛИЗАЦИИ ПРАВОВОЙ ПОЛИТИКИ
Creators: name: ФЕТИСОВ Сергей Александрович
Publisher: name: Образование и право
Year: 2020
Subjects: право
правовая политика
Конституционный Суд РФ
формы реализации правовой политики
правотворчество
законотворчество

description: В статье описываются основные формы реализации правовой политики, субъекты правовой политики. Отмечается особая роль Конституционного суда Российской Федерации при реализации правовой политики. Выделяются проблемы реализации правовой политики и пути их решения.
Predictors of acute toxicities during definitive chemoradiation using intensity-modulated radiotherapy for anal squamous cell carcinoma
Creators: name: Julie, Diana A. R.
name: Oh, Jung Hun
name: Apte, Aditya P.
name: Deasy, Joseph O.
name: Tom, Ashlyn
name: Wu, Abraham J.
name: Goodman, Karyn A.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Purpose. To identify clinical and dosimetric factors associated with acute hematologic and gastrointestinal (GI) toxicities during definitive therapy using intensity-modulated radiotherapy (IMRT) for anal squamous cell carcinoma (ASCC). Materials and methods. We retrospectively analyzed 108 ASCC patients treated with IMRT. Clinical information included age, gender, stage, concurrent chemotherapy, mitomycin (MMC) chemotherapy and weekly hematologic and GI toxicity during IMRT. From contours of the bony pelvis and bowel, dose-volume parameters were extracted. Logistic regression models were used to test associations between toxicities and clinical or dosimetric predictors. Results. The median age was 59 years, 81 patients were women and 84 patients received concurrent MMC and 5-fluorouracil (5FU). On multivariate analysis (MVA), the model most predictive of Grade 2 + anemia included the maximum bony pelvis dose (Dmax), female gender, and T stage [p = 0.035, cross validation area under the curve (cvAUC) = 0.66]. The strongest model of Grade 2 + leukopenia included V10 (percentage of pelvic bone volume receiving ≥ 10 Gy) and number of MMC cycles (p = 0.276, cvAUC = 0.57). The model including MMC cycle number and T stage correlated best with Grade 2 + neutropenia (p = 0.306, cvAUC = 0.57). The model predictive of combined Grade 2 + hematologic toxicity (HT) included V10 and T stage (p = 0.016, cvAUC = 0.66). A model including VA45 (absolute bowel volume receiving ≥ 45 Gy) and MOH5 (mean dose to hottest 5% of bowel volume) best predicted diarrhea (p = 0.517, cvAUC = 0.56). Conclusion. Dosimetric constraints to the pelvic bones should be integrated into IMRT planning to reduce toxicity, potentially reducing treatment interruptions and improving disease outcomes in ASCC. Specifically, our results indicate that Dmax should be confined to ≤ 57 Gy to minimize anemia and that V10 should be restricted to ≤ 87% to reduce incidence of all HT.
ГАРАНТИИ ОХРАНЫ (ЗАЩИТЫ) ПРАВА НА ЛИЧНУЮ НЕПРИКОСНОВЕННОСТЬ В РОССИИ: ПОНЯТИЕ, СОДЕРЖАНИЕ, ВИДЫ
Creators: name: МЕЦГЕР Андрей Александрович
Publisher: name: Образование и право
Year: 2020
Subjects: права человека
гарантии прав
защита прав человека
конституционные гарантии
демократия
гражданское общество
статус гражданина

description: Видами юридических гарантий личной неприкосновенности граждан в оперативно-розыскной деятельности органов внутренних дел являются гарантии охраны (защиты) права на личную неприкосновенность, меры правовой защиты, при рассмотрении которых в настоящей статье автор придерживается их разграничения на меры защиты и меры юридической ответственности, а также меры по предупреждению и пресечению нарушений данного права. Если нарушение права граждан на личную неприкосновенность состоялось, то в действие должны быть приведены меры пресечения, которые направлены на принудительное прекращение данного противоправного действия. Заключительной гарантией охраны (защиты) личной неприкосновенности граждан в оперативно-розыскной деятельности органов внутренних дел являются меры профилактики и предупреждения нарушения права на личную неприкосновенность.
MPEC 2024-G179 : 2024 GT4
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 GT4

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
PAC-Australia (2018): Recording with DS, "A Christmas interview"
Creators: name: Mas, Erwanne
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Australian English
subject: eng

description: PAC-LVTI Reading Task
description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
MPEC 2024-E53 : 2024 CZ11
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 CZ11

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Resolution of All Unresolved Physical Phenomena from the Complete Theory of Everything
Creators: name: Ayotte, Chandler Ayotte
Publisher: name: Zenodo
Year: 2025
Subjects: Quantum mechanics
Quantum gravity
Cosmology
Entropy
Dark energy
Dark matter
Space time emergence
Information encoding
Surface entropy
Fundamental constants
Holographic principle
Causal structure
Barry on a symmetry
Baryon asymmetry
emergent time
Unified horizon theory
Theory of everything
Is entropy geometry
entropy geometry

description: This companion document to The Complete Theory of Everything (Unified Horizon Theory) Master Edition formally resolves all major unsolved physical phenomena in modern physics. Each section addresses a specific unresolved problem—such as dark matter, dark energy, baryon asymmetry, quantum gravity, and more—and derives its resolution directly from the principles outlined in the Unified Horizon Framework.

 

By treating spacetime, mass, energy, and fields as emergent properties of encoded entropy on causal surfaces, this work demonstrates the complete explanatory power of the theory. No speculative particles or extensions beyond established physics are required. All physical constants, particle behaviors, and cosmological observations arise from a unified entropic surface geometry.

 

This document serves as a formal supplement to Ayotte (2025) and provides a comprehensive bridge from theoretical foundation to total physical unification.

 

Cite as:

Ayotte, C. (2025). Resolution of All Unresolved Physical Phenomena from the Complete Theory of Everything (Supplement to Unified Horizon Theory). Zenodo. https://doi.org/10.5281/zenodo.15242643
«ДОСТОЙНОЕ КАЧЕСТВО ЖИЗНИ» И «БЛАГОПОЛУЧИЕ ЛИЧНОСТИ» КАК КОНСТИТУЦИОННО-ПРАВОВЫЕ ЦЕННОСТИ
Creators: name: ТЕПЛОВА Дарья Олеговна
Publisher: name: Образование и право
Year: 2020
Subjects: Конституция
конституционализм
достойное качество жизни и благополучие
национальная безопасность.

description: В данной статье предпринята попытка дать обоснование таких конституционно-правовых ценностей, как «достойное качество жизни» и «благополучие личности». Достойное качество жизни становится той социальной ценностью в политике государства, которая обеспечивает счастье и жизнеспособность каждой личности и общества. Не случайно в некоторых государствах были учреждены министерства счастья, основной задачей которых становится изучение и разработка социальной политики в создании комфортного существования граждан. Категория «достойное качество жизни», по мнению специалистов, затрагивает все аспекты жизни человека: обеспеченность материальными благами, пища, одежда, жилье, безопасность, доступность медицинской помощи, возможности для получения образования и развития способностей, состояние природной среды, социальные отношения в обществе, включая свободу выражения мнений и влияние граждан на политические решения. Отсюда понимание Основного Закона страны невозможно без осознания той социальной роли, которая обусловливает технологию достижения благополучия, и даже счастья любой личности. Автор попытался провести некоторые корреляции, которые демонстрируют значение Конституции как «дорожной карты» достижения благополучия личности, общества и государства.
ЗАМЕТКИ К ВОПРОСУ О РАЗРАБОТКЕ ТЕОРИИ ЮРИДИЧЕСКОЙ ОТВЕТСТВЕННОСТИ
Creators: name: МИЛЬКОВ А. В.
Publisher: name: Образование и право
Year: 2020
Subjects: юридическая ответственность
ответственность за правонарушение
позитивная юридическая ответственность
теория юридической ответственности.

description: В статье рассматриваются этапы развития учения о юридической ответственности в отечественной правовой доктрине. Акцентируется внимание на потребности правовой науки в выработке родового понятия юридической ответственности, способного стать основой теории юридической ответственности. Исследуются доктринальные подходы к определению понятия юридической ответственности, выявляется причина, по которой усилия правоведов по созданию целостной теории юридической ответственности не увенчались успехом. Такой причиной автор считает методологический раскол, приведший к разделению правоведов на два лагеря: сторонников традиционного понимания юридической ответственности как ответственности за правонарушение и сторонников «нового» понимания ответственности как обязанности по соблюдению требований правовых норм. Анализируется и критически оценивается высказанное в литературе предложение об отказе от понятия «ответственность за правонарушение».
РАЗВИТИЕ КОНСТИТУЦИОНАЛИЗМА И КРИЗИС В ПРАВЕ: ТЕНДЕНЦИИ ВЗАИМООБУСЛОВЛЕННОСТИ
Creators: name: БОЧКАРЕВ С. В.
Publisher: name: Образование и право
Year: 2020
Subjects: конституционализм
кризис в праве
право
конституция
модели конституционализма.

description: В статье анализируется взаимообусловленность развития конституционализма с кризисными явлениями в праве. Выделяются основные тенденции развития конституционализма, как многокомпонентной правовой категории. Подчеркивается, что конституционализм всегда имеет конкретно-национальный характер, специфику которого в каждой стране определяет сущностное наполнение элементов, составляющих категорию конституционализма. Отмечается, что кризис в праве влияет на эволюцию отдельных составных элементов конституционализма.
Overestimation of nanoparticles-induced DNA damage determined by the comet assay
Creators: name: Ferraro, Daniela
name: Anselmi-Tamburini, Umberto
name: Tredici, Ilenia Giuseppina
name: Ricci, Vittorio
name: Sommi, Patrizia
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: The increasing use of engineered nanoparticles (NPs) in a wide range of commercial products raises concern about the possible risks that NPs pose to human health. Many aspects of the interaction between living cells and NPs are still unclear, and a reliable assessment of NP genotoxicity would be important. One of the most common tests used for genotoxicity is the comet assay, a sensitive method measuring DNA damage in individual cells. The assay was originally developed for soluble molecules, but it is also used in the assessment of genotoxicity of NPs. However, concerns have been raised recently about the reliability of this test in the case of NPs, but no conclusive results have been presented. Using nuclei isolated from human epithelial cells incubated with NPs, we obtained clear evidence of overestimation of NP genotoxicity by the comet assay in the case of CeO2, TiO2, SiO2, and polystyrene NPs. Removal of the NPs in the cytoplasm was effective in eliminating this genotoxicity overestimation (ex post damage) and determining the actual damage produced by the NPs during incubation with the cells (ex ante damage). This method could improve significantly the determination of NP genotoxicity in eukaryotic cells.
Economic Policy Trends: Better in Theory? Why a Basic Income is Not the Right Tool for this Moment
Creators: name: Cameron, Anna
name: Petit, Gillian
Publisher: name: The School of Public Policy Publications
Year: 2020

description: As the COVID-19 pandemic forces more non-essential businesses to shutter and leaves a growing number of workers out of a job, policy experts, academics, and public figures alike have touted a basic income as the ideal policy for delivering financial relief to struggling Canadians.
description: The School of Public Policy Publications, Vol 13 (2020)
СТАТИЧЕСКИЕ И ДИНАМИЧЕСКИЕ СОСТАВЛЯЮЩИЕ КОНЦЕПЦИИ ГАРМОНИЗАЦИИ РОССИЙСКОГО ЗАКОНОДАТЕЛЬСТВА
Creators: name: ВИЛЬСКАЯ Наталья Викторовна
Publisher: name: Образование и право
Year: 2020
Subjects: статическая гармонизация
динамическая гармонизация
акты субъектов Российской Федерации
предметы совместного ведения Российской Федерации и ее субъектов.

description: В статье проводится анализ статического и динамического уровней гармонизации отечественного законодательства по предметам совместного ведения Российской Федерации и ее субъектов в рамках ст. 72 Конституции РФ. В ходе исследования установлено, что большая заслуга в этом процессе принадлежит федеральным органам государственной власти. Именно они определяют векторы развития законодательства, инициируют принятие новых законов по предметам совместного ведения Российской Федерации и её субъектов, внесение изменений в действующие
ПРИМИРИТЕЛЬНЫЕ ПРОЦЕДУРЫ В АДМИНИСТРАТИВНОМ СУДОПРОИЗВОДСТВЕ: НОВЫЕ ВОЗМОЖНОСТИ УРЕГУЛИРОВАНИЯ СПОРОВ НА ОСНОВЕ СОГЛАШЕНИЯ СТОРОН
Creators: name: ГАНИЧЕВА Екатерина Севериановна
Publisher: name: Образование и право
Year: 2020
Subjects: административное судопроизводство
арбитражный процесс
соглашение о примирении
мировое соглашение
медиация
судебный примиритель
третьи лица
заинтересованные лица.

description: В ходе развития и совершенствования правовых средств, способствующих мирному урегулирование юридических споров, рассматриваемых судами общей юрисдикции и арбитражными судами, остается актуальным вопрос об использовании соглашения о примирении и мирового соглашения в административном судопроизводстве. Давний интерес к этой проблематике объясняется тем, что в основе таких споров лежит конфликт с участием властных субъектов, реализующих свои функции в сфере публичного управления и призванных обеспечивать интересы государства и общества. На фоне краткой ретроспективы развития административного судопроизводства, доктринальных воззрений на правовую природу дел, возникающих из административных и иных публично-правовых отношений, а также с учетом новейших изменений процессуального законодательства в статье анализируется тенденция к расширению возможностей сторон административного спора завершить конфликт на основе взаимоприемлемых договоренностей. Рассмотрены некоторые отличия норм КАС РФ и АПК РФ в части регулирования соглашения о примирении и мирового соглашения. Сделан вывод, что они не обусловлены объективными причинами и могут быть преодолены в ходе дальнейшей унификации процессуального законодательства. Отдельное внимание уделено новому виду примирительных процедур – судебному примирению при посредничестве судьи в отставке. Это, по мнению автора, наиболее приемлемый вид посредничества при урегулировании споров, возникающих из административных и иных публично-правовых отношений.
PAC-Australia (2018): Recording with DS, word list n°1
Creators: name: Mas, Erwanne
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Australian English
subject: eng

description: PAC word list n°1
description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7