cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Changes in body mass index in Canadians over a five-year period: Results of a prospective, population-based study
Creators: name: Hopman, Wilma M.
name: Leroux, Cristine
name: Berger, Claudie
name: Joseph, Lawrence
name: Barr, Susan I.
name: Prior, Jerilynn C., 1943-
name: Harrison, Mark (Assistant Professor)
name: Poliquin, Suzette
name: Towheed, Tanveer
name: Anastassiades, Tassos
name: Goltzman, David
Publisher: name: BioMed Central
Year: 2016

description: Background: The initiation of the Canadian Multicentre Osteoporosis Study in 1996, and subsequent follow-up of the cohort 5 years later, provided longitudinal body mass index (BMI) data for a random sample of Canadians. Methods: Height and weight were measured at baseline and 5 years and used to calculate BMI and assign one of six weight categories. Multiple imputation was used to adjust for missing weight at year 5. Data were stratified by age and gender. The proportion of participants moving between categories was generated, and multivariable linear regression was used to identify factors associated with weight change. Results: Baseline data were available for 8548 participants, year 5 data for 6721, and year 5 weight was imputed for 1827 (17.6%). Mean BMI for every age and gender group exceeded healthy weight guidelines. Most remained within their BMI classification over 5 years, but when change occurred, BMI category was more likely to increase than decrease. Several sociodemographic, lifestyle and clinical characteristics were associated with change. Conclusion: Mean baseline BMI tended to be higher than recommended. Moreover, on average, men under age 45 and women under age 55 were gaining approximately 0.45 kilograms (one pound) per year, which leveled off with increased age and reversed in the oldest age groups. These findings underscore the need for public health efforts aimed at combating obesity.
The Effect of Politicians’ Moral Rhetoric on Affective Polarization and Political Engagement [Registered Report Stage 1 Protocol]
Creators: name: Wang, Sze Yuh Nina
name: Côté, Éloïse
name: Inbar, Yoel
Publisher: name: figshare
Year: 2024
Subjects: Social and Community Psychology
Psychology not elsewhere classified

description:  
ABSTRACT  Politicians commonly use moral rhetoric to praise virtues and condemn vices. Politicians’ use of negative moral rhetoric (language that condemns wrongdoers and bad behavior) is associated with message diffusion on social media, suggesting that using it may benefit politicians. However, little is known about how viewing messages expressing positive and negative moral rhetoric affects members of the public. We investigate the effects of politicians’ moral rhetoric on members of the American public by exposing partisans and independents to real communications from politicians expressing positive moral rhetoric, negative moral rhetoric, or no moral rhetoric. We hypothesize that for political partisans (i.e., Democrats and Republicans), messages expressing negative moral rhetoric increase partisan animosity while increasing political engagement, whereas messages expressing positive moral rhetoric increase engagement but not animosity. For political independents, we hypothesize that both positive and negative moral rhetoric persuade, but that positive moral rhetoric specifically leads to more positive perceptions of the party using it. 

ITEMS  Stage 1 Registered Report Protocol, Stage 1 Registered Report Supplementary Information,
Molecular characterization of the beta-adrenoceptor gene-family of rainbow trout (Oncorhynchus mykiss)
Creators: name: Nickerson, James G
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Biology, Molecular.
subject: Biology, Neuroscience.

description: beta-Adrenoceptors (beta-ARs) are seven transmembrane domain, G-protein coupled receptors that transduce the cellular effects of the catecholamines, adrenaline (Adr) and noradrenaline (Nadr). Through their interaction with plasma membrane beta-ARs, catecholamines modulate a number of key physiological parameters aimed at allowing an organism to cope with environmental and physiological stressors. Mammalian species express three distinct beta-AR subtypes (beta 1-, beta2- and beta3-ARs) that exhibit complex modes of regulation and interaction. Relatively few studies have focused on beta-ARs from early branching vertebrates such as fish, particularly at the molecular level. The goal of this study was to characterize the beta-AR gene-family of the rainbow trout (RbT), Oncorhynchus mykiss. Three putative beta-ARs genes were cloned and a phylogenetic analysis predicted one beta2-AR subtype (RbT beta2-AR) and two beta3-AR subtypes (RbT beta3a- and RbT beta 3b-ARs) relative to the established mammalian beta-AR classification. The RbT beta2-, beta3a- and beta3b-AR genes code for proteins of 409, 427 and 477 amino acids, respectively. Hybridization of gene specific probes to trout tissue RNA indicated that RbT beta 2-AR was highly expressed in the liver, red muscle, and white muscle; RbT beta3a-AR was highly expressed in the gill and heart while RbT beta3b-AR was highly expressed in the blood. Pharmacological analysis indicated RbT beta2-AR binding characteristics consistent with mammalian beta2-ARs while the RbT beta3b-AR showed characteristics that were different from all known mammalian beta-AR subtypes. Differences in the potential regulatory phosphorylation profiles between trout beta-ARs suggests subtype specific sensitivities to the classic mechanisms of beta-AR desensitization. This molecular characterization of trout beta-ARs is the first study to demonstrate a beta3-AR homolog in fish, it identifies the trout red blood cell beta-AR as a beta3-subtype and provides support for the presence of a complex and unique beta-AR signaling system in the rainbow trout.
title: Sicherheitsempfinden, Sicherheitskommunikation und Sicherheitsmaßnahmen
title: Ergebnisse aus dem Forschungsverbund WiSima
titleType: Subtitle
Creators: name: (:Unkn) Unknown
Publisher: name: Freie Universität Berlin
Year: 2020
Subjects: subject: Sicherheitsempfinden
subject: Sicherheitskommunikation
subject: Sicherheitsmaßnahmen
subject: Forschungsverbund WiSima
subject: öffentlicher Personenverkehr
subject: 300 Sozialwissenschaften::380 Handel, Kommunikation, Verkehr::380 Handel, Kommunikation, Verkehr
subject: 300 Sozialwissenschaften::380 Handel, Kommunikation, Verkehr::385 Schienenverkehr

description: In Deutschland werden im öffentlichen Personenverkehr (ÖPV) jährlich rund 10 Mrd. Fahrgäste transportiert. Die Reisenden erwarten in den Fahrzeugen und Bahnhöfen ein hohes Niveau an Sicherheit, das durch entsprechende Maßnahmen gewährleistet werden muss. Die Herausforderung besteht dabei darin, Sicherheit mit wirtschaftlich tragbaren Maßnahmen zu realisieren. Das Projekt WiSima erarbeitet Vorschläge, mit denen – ohne Reduzierung der Sicherheitsstandards und bei gleichzeitiger Kostenreduzierung – eine Verbesserung des Sicherheitsempfindens der Fahrgäste erreicht werden kann.
Les obstacles procéduraux à la repression interne des crimes de guerre et des crimes contre l'humanité
Creators: name: Hitimana, Célestin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Law.
subject: Political Science, General.

description: Le droit international crée une obligation, qui incombe aux États, de réprimer les crimes de guerre et contre l'humanité sous le tripode de la compétence territoriale, personnelle et universelle, dans le respect strict des règles d'un procès équitable. Dans cette étude, nous identifions et analysons les principaux empêchements procéduraux auxquels font face les tribunaux nationaux lorsqu'ils tentent de poursuivre les auteurs de ces crimes. Notre hypothèse de travail postule que des obstacles formels de droit interne, dont la conformité au droit international n'est pas certaine, forcent les autorités judiciaires nationales à ne pas entreprendre ou à abandonner, avant le débat de fond, les poursuites contre ces personnes. D'un point de vue méthodologique, nous avons privilégié la méthode inductive, analysant les pratiques étatiques par rapport à l'obligation internationale d'ordre conventionnel de "rechercher et poursuivre" les auteurs de crimes de guerre et contre l'humanité qui se trouvent sur le territoire national. Partant du point de vue général, notre recherche aborde l'étude d'un cas sui generis, en l'occurrence celui du Burundi. Au titre d'exceptions d'incompétence juridictionnelle insurmontables, nous discutons du défaut de pénalisation au niveau national des crimes de guerre et contre l'humanité, de la non extension de la compétence extraterritoriale des tribunaux nationaux à ces crimes et des immunités et privilèges de juridiction pénale dont jouissent les dirigeants en exercice d'un État. Au titre d'exceptions d'irrecevabilité de l'action publique, nous analysons le rôle discriminant des lois d'amnistie et de prescription. En plus de ces obstacles de droit, nous avons identifié des obstacles de fait qui empêchent de poursuivre un criminel de guerre ou contre l'humanité, à savoir le manque de moyens, l'évitement de coûts politique et économique fâcheux, l'application de mesures administratives alternatives aux poursuites ainsi que l'état de santé et l'âge avancé de l'inculpé. Dans le cas particulier du Burundi, des acteurs plus imaginatifs ont introduit des critères nouveaux tel que l'immunité provisoire. Cette expérience témoigne de l'importance des obstacles formels à soustraire à la justice étatique les suspects et plaide pour une sérieuse réévaluation de sa contribution à la lutte contre l'impunité.
Realization of Critical Eigenvalues for Systems of Linear Delay Differential Equations
Creators: name: Giordano, Gael
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: subject: Mathematics.

description: This thesis is a step forward in the generalization of the Realization Theorem in the paper [15] by Buono and LeBlanc. In that theorem, the two authors study the link between the number of critical eigenvalues and the number of delays in a scalar delay differential equation of the form: y&d2;t =j=1lajy t-tj,a j∈R. In this thesis, we shall consider a system of p ( p ∈ N ) scalar delay-differential equations. That system can be written as: y&d2;t =j=1lMjy t-tj,M j∈Mp R. The goal is therefore to study the links between the number of critical eigenvalues, the number of delays and the number p of equations. We study these links in three particular cases. First of all, we are interested in the case l = 1. That is y˙(t) = My( t - tau). Secondly, we consider the equation y˙ (t) = M1y( t - tau1) + M2 y(t - tau2), Mj ∈ M2R . Finally, we study the case: y&d2;t =j=1lMjy t-tj where the matrices Mj ∈ Mp R are diagonal, for 1 ≤ j ≤ l.
Use of immunohistochemical markers can refine prognosis in triple negative breast cancer
Creators: name: Tischkowitz, Marc
name: Brunet, Jean-Sébastien
name: Bégin, Louis R.
name: Huntsman, David G.
name: Cheang, Maggie C.
name: Akslen, Lars A.
name: Nielsen, Torsten
name: Foulkes, William D.
Publisher: name: BioMed Central
Year: 2015

description: Background: Basal-like breast cancer has been extensively characterized on the basis of gene expression profiles, but it is becoming increasingly common for these tumors to be defined on the basis of immunohistochemical (IHC) staining patterns, particularly in retrospective studies where material for expression profiling may not be available. The IHC pattern that best defines basal-like tumors is under investigation and various combinations of ER, PR, HER2-, CK5/6+ and EGFR+ have been tested. Methods Using datasets from two different hospitals we describe how using different combinations of immunohistochemical patterns has different effects on estimating prognosis at different time intervals after diagnosis. As our baseline, we used two IHC patterns ER-/PR-/HER2-("triple negative phenotype", TNP) and ER-/HER2-/CK5/6+ and/or EGFR+ ("core basal phenotype", CBP). Results There was no overall difference in survival between the two hospital-based series, but there was a difference between the TNP and non-TNP groups which was most marked at 3 years (76.8% vs 93.5%, p <.0001). This difference reduced with time, suggesting that long term survivors (beyond 10 years) in the TNP group may have comparable survival to non-TNP cases. A similar difference was seen if CBP was used instead of TNP. However when CK5/6 and/or EGFR expressing tumors were analyzed without consideration of ER/PR status, the reduction in survival increased with time, becoming more pronounced at 10 years than at 3 years. Conclusion Our findings suggests that CK5/6 and/or EGFR expressing tumor types have a persistently poorer prognosis over the longer term, an observation that may have important therapeutic implications as drugs that target the EGFR are currently being evaluated in breast cancer.
Extract from a MS. diary of Peter le Neve, Esq, Norroy king of arms, entitled Memoranda in Heraldry of such entries as relate to the county of Norfolk. (Part 1 on P23 - Part 2 on P111)
Creators: name: Carthew, G A
Publisher: name: Archaeology Data Service
Year: 2020

description: Norfolk Archaeology, 3 (1), 369-396
Absence of mutations in NR2E1 and SNX3 in five patients with MMEP (microcephaly, microphthalmia, ectrodactyly, and prognathism) and related phenotypes
Creators: name: Kumar, Ravinesh A.
name: Everman, David B.
name: Morgan, Chad T.
name: Slavotinek, Anne
name: Schwartz, Charles E.
name: Simpson, Elizabeth M.
Publisher: name: BioMed Central
Year: 2016

description: Background: A disruption of sorting nexin 3 (SNX3) on 6q21 was previously reported in a patient with MMEP (microcephaly, microphthalmia, ectrodactyly, and prognathism) and t(6;13)(q21;q12) but no SNX3 mutations were identified in another sporadic case of MMEP, suggesting involvement of another gene. In this work, SNX3 was sequenced in three patients not previously studied for this gene. In addition, we test the hypothesis that mutations in the neighbouring gene NR2E1 may underlie MMEP and related phenotypes. Methods: Mutation screening was performed in five patients: the t(6;13)(q21;q12) MMEP patient, three additional patients with possible MMEP or a related phenotype, and one patient with oligodactyly, ulnar aplasia, and a t(6;7)(q21;q31.2) translocation. We used sequencing to exclude SNX3 coding mutations in three patients not previously studied for this gene. To test the hypothesis that mutations in NR2E1 may contribute to MMEP or related phenotypes, we sequenced the entire coding region, complete 5' and 3' untranslated regions, consensus splice-sites, and evolutionarily conserved regions including core and proximal promoter in all five patients. Two-hundred and fifty control subjects were genotyped for any candidate mutation. Results: We did not detect any synonymous nor nonsynonymous coding mutations of NR2E1 or SNX3. In one patient with possible MMEP, we identified a candidate regulatory mutation that has been reported previously in a patient with microcephaly but was not found in 250 control subjects examined here. Conclusion: Our results do not support involvement of coding mutations in NR2E1 or SNX3 in MMEP or related phenotypes; however, we cannot exclude the possibility that regulatory NR2E1 or SNX3 mutations or deletions at this locus may underlie abnormal human cortical development in some patients.
title: Pêcher :
title: Principes directeurs pour la conduite de l’examen de la distinction, de l’homogénéité et de la stabilité.
titleType: Subtitle
Creators: name: (:Unas)
Publisher: name: Unknown
Year: 2011

description: Ces principes directeurs (“principes directeurs d’examen”) visent à approfondir les principes énoncés dans l’introduction générale (document TG/1/3) et dans les documents TGP qui s’y rapportent afin de donner des indications concrètes détaillées pour l’harmonisation de l’examen de la distinction, de l’homogénéité et de la stabilité (DHS) et, en particulier, à identifier des caractères convenant à l’examen DHS et à la production de descriptions variétales harmonisées.
Multiculturism in Vikram Seth's The Golden Gate
Creators: name: Sanjay Kumar
Publisher: name: Zenodo
Year: 2024

description: Vikram Seth's novel The Golden Gate, set in the vibrant and diverse landscape of San Francisco in the 1980s, is a strikingexample of multiculturalism in contemporary literature. The novel, written in verse, explores the lives, loves, andrelationships of a group of friends, offering a window into the city's multifaceted cultural and social tapestry. Through itscharacters, settings, and themes, The Golden Gate highlights the dynamics of multiculturalism, reflecting the complexitiesand richness of a society composed of diverse cultural identities.The novel's cast of characters is a testament to its multicultural milieu. John, the central character, is a software engineerof European descent, representing the professional and technological heart of Silicon Valley. His close friend, Phil Weiss,a Jewish activist, and musician, embodies the city's spirit of social engagement and artistic expression. Janet Hayakawa,John's ex-girlfriend and a Japanese-American sculptor, brings another layer of cultural diversity, emphasizing thepresence and contributions of Asian Americans in the Bay Area. The interactions and relationships among thesecharacters underscore the novel’s exploration of cultural identity and integration. For instance, the romance between Johnand Liz Dorati, a single mother with Italian heritage, reflects the blending of different cultural backgrounds. This fusion ofidentities is further complicated by their interactions with other characters, such as Ed, Liz’s son, who navigates his mixedheritage in a multicultural environment.
Dynamics of solar thermochemical methane decomposition for hydrogen and carbon black production
Creators: name: Allam, Raaid
Publisher: name: Macquarie University
Year: 2024
Subjects: classificationCode: 401204
subject: Computational methods in fluid flow, heat and mass transfer (incl. computational fluid dynamics)

description: This work reviews various aspects of the methane thermal decomposition process such as the initiation step, production of C2 hydrocarbons/higher hydrocarbons/polyaromatic hydrocarbons (PAHs), mechanism steps for the purpose of kinetic modelling, carbon catalysts to enhance the decomposition process, solar radiation for the purpose of methane pyrolysis, solar reactor configurations and kinetic/mathematical studies concerning the estimation of kinetic parameters. Carbon seeding in reactors demonstrated the advantage of providing a catalytic effect to the decomposition process through surface reactions on active sites and via enhancing heat exchange within the reactor. Mathematical and numerical modelling of the methane decomposition process is important to understanding process aspects which are experimentally challenging such as axial variation of products and intermediates, determination of reactor temperature profiles and identification of reactions or dead zones. Current studies demonstrate the numerical modelling of methane pyrolysis either with autocatalysis from nucleated carbon or with injected seeded catalyst. There are no current CFD-kinetic modelling studies that include both the effects of autocatalysis and injected catalysts. In this study, a combined methodology was employed using the Eularian-Lagrangian framework in ANSYS Fluent to predict gaseous and solid products yields. The particle behaviour included in this study were particle nucleation due to homogenous reactions and growth due to heterogeneous reactions. The model was able to predict hydrogen and other hydrocarbon yields in a fair agreement in comparison to experimental results. The model tested two cases of seeding mass flow rates 1.62 g/h and 3.14 g/h. Simulation results were compared to experimental outcomes, with a focus on H2 yield. The comparison revealed a close correlation between simulation and experiment, with an acceptable error margin of 10.4% for the 1.62 g/h case and 9.5% for the 3.14 g/h case. Concentrations of hydrocarbons such as ethane and ethylene at the outlet were negligible compared to hydrogen and acetylene, making accurate predictions challenging. Seeding was found to increase methane conversion, with a notable effect on the 3.14 g/h case due to enhanced contact between methane molecules and catalyst surfaces. The study concludes by emphasizing the importance of developing a methodology that incorporates simple kinetic mechanisms into 2D or 3D models. This involves reviewing simulation work and creating an iterative method to adjust kinetic rates for accurate correlation with physical testing results under varying conditions.
Battling a Trojan horse: The Ordre de Jacques Cartier and the Knights of Columbus, 1917--1965
Creators: name: Trepanier, James
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Religion, History of.
subject: History, Canadian.

description: This study examines the creation and growth of the Ordre de Jacques Cartier (OJC) - a French-Canadian Catholic secret society created in Ottawa - and its opposition to the Knights of Columbus - a Catholic fraternity created in Connecticut in the late nineteenth century but which had expanded into Ontario and Quebec by the early twentieth century---from 1917 to 1965. Historians of French-Canadian nationalism in the early to mid twentieth century have largely passed over the Ordre de Jacques Cartier and the Knights of Columbus in their studies of Catholic movements and associations. The few studies that have looked at the OJC have downplayed the influence that the Knights of Columbus had on the secret society and its campaigns. This study seeks to fill that gap in looking at how the OJC anti-Knight campaign reflects shifts in French-Canadian nationalism and conception of French-Canadian identity. More specifically, by taking a closer look at the attitudes of the OJC's leaders towards the Knights of Columbus, a more nuanced picture of relations between French-Canadian nationalists in Quebec and Ontario emerges. This study argues that the OJC's campaign against the Knights reveals the shifting priorities both of its Ottawa-based leadership and its growing Quebec membership base. Differences of opinion over the Knights of Columbus in Quebec and Ontario from the end of the Great War are symptomatic of the eventual schism between neo-nationalists in Quebec and French-Canadian nationalists in Ontario that came to the fore in the 1960s with the Quiet Revolution in Quebec and the dissolution of the OJC. Using both the archives of the Knights of Columbus and the OJC, this study will analyze the increasing emphasis on territorial autonomy in Quebec by nationalists as well as how lay movements both preceded, and were part of, shifting nationalist discourse in the mid-twentieth century.
OLIY TA'LIM MASSASALARIDA TA'LIM JARAYONINI TASHKIL ETIShDA KO'P AGENTLI TEXNOLOGIYALARDAN FOYDALANISH.
Creators: name: Xojaniyazova, S.P.
Publisher: name: Zenodo
Year: 2024

description: Bu jarayonga ta’lim va kadrlar tayyorlash sohasida jadal axborotlashtirish, axborot kommunikatsiyalari, raqamli texnologiyalar, sun’iy intellekt, neyron tarmoqlar, multi-agentli tizim va texnologiyalardan keng joriy etilmoqda. Multi-agent texnologiyasidan foydalangan holda o'quv faoliyatini tashkil etish oliy o'quv yurtlari talabalarining kasbiy kompetensiyalarini rivojlantirish imkonini beradi. Innovatsion metodlar, ko‘rgazmali didaktik o‘qitish vositalari, o‘qitish shakllarini ishlab chiqish, ta’lim modellarini takomillashtirish va raqobatbardosh kadrlar tizimini rivojlantirish bugungi kunning dolzarb pedagogik vazifalaridan biridir.
On The Processing of Log Files for Monitoring Antenna Health
Creators: name: Habana, Nlingi
name: Petrov, Leonid
Publisher: name: Zenodo
Year: 2024
Subjects: VLBI
Tsys
Phase Calibration
Antenna Telemetry
Geodesy

description: In order to improve the quality of geodetic results, we have developed an infrastructure for timely processing of telemetry from IVS observing stations. The slides herein describe that process, and the results of the data analysis. We check every hour for new log files with telemetry from both VLBI observing sessions, single dish experiments, and stow-in data collection and automatically process them. The telemetry data we use is the system temperature, phase calibration phases and amplitudes, system equivalent flux density, and the differences between formatter clock and GPS clock. For the system temperature and phase calibration, processing includes filtering out outliers and computing averages and rms of the scatter in each scan. Furthermore, for the phase calibration we also compute the group delay and detect spurious signals. Cleaned and post-processed telemetry is archived. Our process detects abnormalities, such as, anomalously high system temperature, unstable phase calibration phases, jumps in the GPS and formatter clock differences, and others. With our procedure, the latency of detection of station abnormalities is reduced to less than two hours. Early detection of abnormalities reduces the amount of affected data since station personnel get early alerts. We discuss our experience of running this system since 2022.
Injection Drug User Quality of Life Scale (IDUQOL): Findings from a content validation study
Creators: name: Hubley, Anita M
name: Palepu, Anita
Publisher: name: BioMed Central
Year: 2015

description: Background: Quality of life studies among injection drug users have primarily focused on health-related measures. The chaotic life-style of many injection drug users (IDUs), however, extends far beyond their health, and impacts upon social relationships, employment opportunities, housing, and day to day survival. Most current quality of life instruments do not capture the realities of people living with addictions. The Injection Drug Users' Quality of Life Scale (IDUQOL) was developed to reflect the life areas of relevance to IDUs. The present study examined the content validity of the IDUQOL using judgmental methods based on subject matter experts' (SMEs) ratings of various elements of this measure (e.g., appropriateness of life areas or items, names and descriptions of life areas, instructions for administration and scoring). Methods Six SMEs were provided with a copy of the IDUQOL and its administration and scoring manual and a detailed content validation questionnaire. Two commonly used judgmental measures of inter-rater agreement, the Content Validity Index (CVI) and the Average Deviation Mean Index (ADM), were used to evaluate SMEs' agreement on ratings of IDUQOL elements. Results A total of 75 elements of the IDUQOL were examined. The CVI results showed that all elements were endorsed by the required number of SMEs or more. The ADM results showed that acceptable agreement (i.e., practical significance) was obtained for all elements but statistically significant agreement was missed for nine elements. For these elements, SMEs' feedback was examined for ways to improve the elements. Open-ended feedback also provided suggestions for other revisions to the IDUQOL. Conclusion The results of the study provided strong evidence in support of the content validity of the IDUQOL and direction for the revision of some IDUQOL elements.
Dynamic Pricing in Electronic Commerce using Neural Network
Creators: name: Ghose, Tapu Kumar
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Business Administration, Marketing.
subject: Artificial Intelligence.
subject: Computer Science.

description: There exist intelligent agents to aid online sellers to dynamically calculate a competitive price for their products in online markets. However, these intelligent agents usually make a number of assumptions for dynamic pricing. Some intelligent agents assume that sellers consist of prior knowledge about the online market parameters. In other words, the agents assume that the sellers are well aware of other competitors' pricing strategies, consumers purchase preferences, consumers' reservation price, profit made by other competing sellers etc. In addition, other agents assume that price is the only attribute that determines consumers' purchase decision. On the contrary, in real life sellers have limited or no prior knowledge about the market parameters. In addition, nowadays along with price other attributes such as after sale service, product quality etc. contribute in determining consumers' purchase decision. In this thesis, we propose an approach where sellers have limited knowledge on market parameters. We also assume that buyers' purchase decisions are based on multiple attributes. We are using a feed-forward neural network approach for calculating a competitive price dynamically to increase the sellers' revenue. Product price, product quality, delivery time, after sales service and seller's reputation are taken into consideration while determining the competitive price of the product by our model. In our experimental evaluation we showed that once the sellers, by considering the five attributes, set an initial price of the product, our model adjusts the price of the product automatically with the help of neural network in order to raise the revenue. In setting the initial price of a product, we assume that sellers use their prior knowledge about the prices of the product offered by other competing sellers. Any other prior knowledge like buyer demand or competitor's price setting behaviors is not used in our evaluation. The experimental results portray the effect of considering the five attributes in earning revenue by the sellers. Before concluding with directions for future works, we discuss the value of our approach in contrast with related work.
SOCIO-PHILOSOPHICAL ANALYSIS AND SIGNIFICANCE OF THE SPIRITUAL AND MORAL VIEWS OF ALISHER NAVOI IN THE NEW UZBEKISTAN
Creators: name: Ochilova, Maftuna
Publisher: name: Zenodo
Year: 2024

description: This article provides a philosophical analysis of the spiritual and moral views of The Thinker Alisher Navoi. The socio-philosophical significance of spirituality and morality in the creation of the foundation of a new Uzbekistan is highlighted. The poetic verses of Alisher Navoi have been philosophically analyzed.
SERVICE BEYOND SELF: A COMPREHENSIVE STUDY ON THE INFLUENCE OF VOLUNTEERISM IN HIGHER EDUCATION – A SHENZHEN UNIVERSITY PERSPECTIVE
Creators: name: Mei, Ling Zhang
name: Jian, Wei Liu
Publisher: name: AMERICAN SERIAL
Year: 2024
Subjects: Volunteering, Higher Education Institutions, Character Development, Social Responsibility, Experiential Learning

description: Volunteering in higher education institutions plays a pivotal role in fostering students' values, character development, and active engagement in societal progress. Shenzhen, as the pioneer city in China to establish a "City of Volunteers" in 2011, initiated the concept of "Volunteer Campuses" within local institutions. Through effective institutional oversight, brand development, and infrastructure enhancement, universities have integrated volunteer service into their campus culture, profoundly impacting young minds and contributing to the cultivation of a culture of volunteerism and character development. Engaging in volunteer activities within higher education institutions has a profound impact on students' principles and worldviews. Firstly, it instills a sense of social responsibility and dedication in students, as they directly witness society's challenges and difficulties. This firsthand experience fosters empathy and compassion towards marginalized communities, motivating students to reflect on issues of social justice and equity, thereby nurturing their willingness to actively assume societal responsibilities. Secondly, volunteer service provides students with a practical platform to translate their principles and beliefs into tangible actions. Theoretical knowledge acquired in the classroom gains real-world application through experiential learning. By actively participating in volunteer service initiatives, students have the opportunity to implement their principles and convictions in concrete ways, fostering a deepened sense of commitment and accomplishment derived from serving others
THE USE OF POLYNOMIAL CODES FOR CONSTRUCTING RELIABLE DISCRETE SYSTEMS OF PROGRAMMABLE LOGIC INTEGRATED CIRCUITS.
Creators: name: Donaboyev, Sh.Sh.
Publisher: name: Zenodo
Year: 2024

description: The thesis examines the historical and technological factors that have driven the integration of Programmable Logic Integrated Circuits (PLIC) into railway automation systems. It underscores the crucial role of polynomial coding in ensuring the reliability of PLIC within digital systems. Polynomial coding is identified as a critical component in the design of reliable systems that utilize PLIC, providing effective error management and supporting the robust operation of complex automation tasks. The thesis further highlights that the integration of PLIC with polynomial coding represents a significant technological advancement, enhancing the resilience, efficiency, and safety of digital systems, particularly in complex and demanding applications such as railway automation. Finally, the thesis emphasizes that polynomial codes are essential for improving the reliability and safety of railway automation systems, making them a foundational element in the ongoing evolution and modernization of the industry.
Production and evaluation of plant-derived vaccines for cytomegalovirus using guinea pig as an animal model
Creators: name: Rolwandson, Karen
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Biology, Microbiology.

description: Human cytomegalovirus (HCMV) infection is usually asymptomatic in healthy individuals. However, severe disease and/or death can occur in immunocompromised patients. The overall objective of this project was to develop a plant-derived CMV subunit vaccine and determine its effectiveness. Since CMV is species-specific, guinea pig CMV (GPCMV) was used as a model for HCMV. Four gene constructs were engineered to contain either the rice glutelin-1 promoter (Gt1) or the maize ubiquitin promoter, and the gene for either glycoprotein B (gB) or phosphoprotein 65 (pp65) of GPCMV. Agrobacterium tumefaciens were transformed with the Gt1-gB construct and subsequently used to transform Oryza sativa (rice) or Arabidopsis thalina . Due to technical difficulties associated with rice transformations, experimental work was continued with only A. thaliana. PCR analysis of plant tissue confirmed maintenance of the gB transgene for seven generations, and Western blots of selected seed extracts revealed a gB-specific band not found in non-transformed A. thaliana extracts. Guinea pigs (4 per group) were subcutaneously immunized with 20 mg of seed protein extract from GPCMV gB A. thaliana plants (estimated to contain approximately 50 mug of gB), an equal amount of total protein from non-transformed A. thaliana seeds (negative control), or baculovirus-derived GPCMV gB (positive control). Two animals immunized with seed-derived gB demonstrated GPCMV-specific antibody responses when analysed by ELISA. Western blot analysis confirmed that this response was specific for GPCMV gB. Neutralization assays were performed using serum obtained 14 days after the last immunization. Three of the 4 animals immunized with the gB seed extract showed viral neutralizing responses, with titres ranging from 40 to 3240. These results indicate that GPCMV gB expressed in the seeds of A. thaliana can generate a GPCMV-specific immune response. Based on data from GPCMV-specific ELlSAs, Western blots, and viral neutralization assays using serum from immunized animals, I concluded that gB was authentically expressed in A. thaliana seeds with at least some epitopes similar to those found on native GPCMV gB that were able to neutralize viral infectivity.
"STIGMACHOLE - ZEA" СУБСТАНЦИЯСИ ТАРКИБИДАГИ ФЛАВОНОИДЛАР МИҚДОРИНИНГ ТАҲЛИЛИ
Creators: name: Маматқулов, Зухридин
name: Ризаев, Камал
Publisher: name: Zenodo
Year: 2024

description: Мақолада маҳаллий доривор ўсимлик хомашёлардан олинган “STIGMACHOLE - ZEA” субстанцияси таркибидаги флавоноидлар миқдори ўрганилди. Тажрибалар асосида субстанция таркибидаги рутин, кверцетин, дигидрокверцетин, сенирозид, солидрозин ва лютеолин каби флавоноидлар миқдори аниқланди. Изланишлар юқори самарали суюқлик хроматография усулида ўтказилди ва “STIGMACHOLE - ZEA” субстанцияси таркибида лютеолиннинг миқдори бошқа флавоноидларга нисбатан юқори эканлиги маълум бўлди.
O'ZBEKISTON TRANSPORT VA LAGISTIKA SOHASIDAGI DOLZARB MASALALAR, TAKLIFLAR VA ULARNING TEXNIK YECHIMLARI TAHLILI
Creators: name: Mengliqulov, Jonibek
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqolada mamlakatimizga lagistika sohasining kirib kelishi, uning  ahamiyati, rivojlanish jarayonida yuzaga kelayotgan bir qator muammolar va ularga atroflicha yechimlar keltirib o‘tilgan. Bundan tashqari O‘zbekistonning lagistik salohiyati statistikalar asosida keng ko‘lamda tahlil qilingan.
Tapinoma dabashanica Seifert & Kaufmann & Fraysse 2024, n.sp.
Creators: name: Seifert, Bernhard
name: Kaufmann, Bernard
name: Fraysse, Lorenzo
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tapinoma
Tapinoma dabashanica

description: Tapinoma dabashanica n.sp.
Etymology: referring to the mountain range Daba Shan where the type sample was collected.
 Type material: Holotype plus 2 paratype worker on the same pin labeled “ China Chongging Dabashan MtR S Gaoguan N 31.819 E 108.902 1590 m asl 2010-05-18 Belousov Kabak & Korolev Chi 2010 182b”; depository SMN Görlitz.
 Geographic range. Only known from the type locality.
 Diagnosis:— Worker (Tab. 7, Figs. 14-16): All shape ratios given below are given in the sequence arithmetic mean [minimum, maximum]. Small-sized, CS 650 [628, 665]. Head elongated CL/CW 1.160 [1.147, 1.182]. Postocular distance medium-sized, PoOc/CL 0.411 [0.409, 0.413]. Anteromedian clypeal excision wider than deep, ExCly/ CS 4.38 [4.25, 4.58]%, ExClyW 8.38 [8.11, 8.82]%. The margin of clypeal excision forms a sharp cuticular edge being at same level as the adjacent clypeal surface. Sum of pubescence hairs and smaller setae protruding at a few micron across margin of clypeal excision low, nExCly 3.67 [3.0, 4.0]. Posterior margin of head in full face view not excavated, ExOcc/ CS 0.0 [0.0, 0.0]%. Scape moderately elongated, SL/ CS 0.991 [0.987, 0.994]. Minimum distance of the inner margins of antennal socket rings medium-sized, dAN 0.300 [0.297, 0.304]. Eye rather long, EL/ CS 0.298 [0.295, 0.303]. Dorsal profile of mesonotum and of propodeum more strongly convex, metanotal depression rather deep, MGr/ CS 2.57 [1.79, 3.62]%. Mesosoma relatively thickset, MW / CS 0.682 [0.658, 0.704], ML / CS 1.293 [1.263, 1.315]. Second funiculus segment short, Fu2L/ CS 12.79 [12.60, 12.91]%, IFu2 1.357 [1.333, 1.380]. Head, mesosoma and gaster covered by a rather dense pubescence. Anterior margin of clypeus with few short standing setae. Remaining surface of head capsule and dorsal mesosoma without standing setae, such are present on mandibles and coxae. Head, mesosoma, gaster, antennal scape, femora and tibiae dark brown. Tarsae, metatarsae and funiculus segments pale yellowish brown.
 Taxonomic comments. For separation from the related species Tapinoma sichuense n. sp. see next chapter.
 Biology. Unknown.
description: Published as part of Seifert, Bernhard, Kaufmann, Bernard & Fraysse, Lorenzo, 2024, A taxonomic revision of the Palaearctic species of the ant genus Tapinoma Mayr 1861 (Hymenoptera: Formicidae), pp. 1-74 in Zootaxa 5435 (1) on page 65, DOI: 10.11646/zootaxa.5435.1.1, http://zenodo.org/record/10954893
Consequences of Amyloid‐β Deficiency for the Liver
Creators: name: Buniatian, Gayane Hrachia
name: Schwinghammer, Ute
name: Tremmel, Roman
name: Cynis, Holger
name: Weiss, Thomas S.
name: Weiskirchen, Ralf
name: Lauschke, Volker M.
name: Youhanna, Sonia
name: Ramos, Isbaal
name: Valcarcel, Maria
name: Seferyan, Torgom
name: Rahfeld, Jens‐Ulrich
name: Rieckmann, Vera
name: Klein, Kathrin
name: Buadze, Marine
name: Weber, Victoria
name: Kolak, Valentina
name: Gebhardt, Rolf
name: Friedman, Scott L.
name: Müller, Ulrike C.
name: Schwab, Matthias
name: Danielyan, Lusine
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: 610 Medizin

description: Abstract

The hepatic content of amyloid beta (Aβ) decreases drastically in human and rodent cirrhosis highlighting the importance of understanding the consequences of Aβ deficiency in the liver. This is especially relevant in view of recent advances in anti-Aβ therapies for Alzheimer's disease (AD). Here, it is shown that partial hepatic loss of Aβ in transgenic AD mice immunized with Aβ antibody 3D6 and its absence in amyloid precursor protein (APP) knockout mice (APP-KO), as well as in human liver spheroids with APP knockdown upregulates classical hallmarks of fibrosis, smooth muscle alpha-actin, and collagen type I. Aβ absence in APP-KO and deficiency in immunized mice lead to strong activation of transforming growth factor-β (TGFβ), alpha secretases, NOTCH pathway, inflammation, decreased permeability of liver sinusoids, and epithelial-mesenchymal transition. Inversely, increased systemic and intrahepatic levels of Aβ42 in transgenic AD mice and neprilysin inhibitor LBQ657-treated wild-type mice protect the liver against carbon tetrachloride (CCl4)-induced injury. Transcriptomic analysis of CCl4-treated transgenic AD mouse livers uncovers the regulatory effects of Aβ42 on mitochondrial function, lipid metabolism, and its onco-suppressive effects accompanied by reduced synthesis of extracellular matrix proteins. Combined, these data reveal Aβ as an indispensable regulator of cell–cell interactions in healthy liver and a powerful protector against liver fibrosis.
Fear of pain in patients with advanced cancer
Creators: name: LeMay, Katerine
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Psychology, Clinical.

description: Pain is one of the most prevalent symptoms in patients with advanced cancer and, according to anecdotal evidence, perhaps the most feared. Surprisingly, fear of pain has been the subject of little research within cancer care. On the other hand, there is a large literature in the area of chronic non-malignant pain that is relevant to this issue. It suggests that fear of pain contributes to pain severity and to limitations in daily activities in various populations with chronic non-malignant pain. However, little is known about the extent to which such findings might generalize from patients with chronic nonmalignant pain to those with chronic cancer pain. Therefore, this research examined the extent to which fear of pain is associated with functional limitations in patients with advanced cancer. In particular, this study compared patients with chronic cancer and non-cancer pain on measures of fear of pain and other related constructs. The primary objective was to investigate, among patients with chronic pain due to advanced cancer, the relationships between fear of pain, catastrophizing, anxiety sensitivity, depression, physical symptoms, pain severity, and limitations in function. A secondary objective was to compare the relationship observed in cancer patients to those observed in patients experiencing chronic non-malignant pain. A total of 235 patients with chronic pain were recruited (117 patients with advanced cancer who received a referral for pain management and 118 patients with a primary complaint of chronic non-malignant pain). Participants completed self-report questionnaires. Findings revealed similarities between the groups for fear of pain, catastrophizing, anxiety sensitivity, physical symptoms, and limitations in function; however, they differed on level of depression and pain severity. Fear of pain and catastrophizing independently predicted disability in both groups; fear of pain predicted pain severity in patients with non-malignant pain. Catastrophizing predicted pain severity in both groups. Fear of pain mediated the relationship between anxiety sensitivity and limitations in function. This study provides an empirical perspective on fear of pain and other psychological constructs among patients with advanced cancer; it integrates the literature on cancer and non-cancer chronic pain, and confirms the value of psychological adjuncts to pain management in cancer.
BADIIY GIMNASTIKANING JISMONIY VA RUHIY SALOMATLIKKA TA'SIRI
Creators: name: Farhodova, Maftuna
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqolada badiiy gimnastikaning jismoniy va ruhiy salomatlikka ta'siri o'rganiladi. Tadqiqot natijalariga ko'ra, badiiy gimnastika nafaqat jismoniy ko'rsatkichlarni yaxshilaydi, balki ruhiy salomatlikka ham ijobiy ta'sir ko'rsatadi. Maqolada badiiy gimnastikaning muskul kuchi, egiluvchanlik, koordinatsiya kabi jismoniy sifatlarni rivojlantirishdagi roli, shuningdek, stress darajasini pasaytirish, o'ziga ishonchni oshirish va ijodiy qobiliyatlarni rivojlantirishdagi ahamiyati muhokama qilinadi.
Poesia y violencia politica Peru 1980-1992
Creators: name: Fernandez, Juan Paolo Gomez
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Language, Modern.
subject: Literature, Latin American.
subject: History, Latin American.

description: Between 1980 and 1992 Peru underwent a bloody internal war characterized by extreme indiscriminate violence. This thesis examines the poetry closely linked---directly or indirectly through mediations---to such political scenario. It analyzes the critical assessment of that process from the point of view of two groups of poets---in both their poems and the way they understood their literary activity: (1) the "three sad tigers" Raiil Mendizabal, Jose Antonio Mazzotti and Eduardo Chirinos; and (2) the Kloaka group, particularly Domingo de Ramos, Roger Santivafiez and Dalmacia Ruiz Rosas. In spite of their differences, the poetic language that interprets the historical and social perspectives adopted by the two groups converged in their expression of marginality vis a vis the official discourse. The six studied authors constitute an important illustration of how the relationship between political violence and poetry can make the language take unprecedented pathways and alter the formai canons in such a way not seen until then in the "official" Peruvian poetry. Rather than being a mere reflection of its context, the poetry of these writers represents a key element of the historical process under which the civil war in Peru took place. It also sets forward rather insightful answers from the perspective of the so called "lettered city" and the Peruvian intelligentsia. According to this thesis, the originality of the poetry of these authors lies in the fact that they became a genuine poetic generation, clearly different from the precedent one of 1960-70. The 1980 generation is characterized by deep disenchantment, anarchy, and auto-immolation, assuming---within its own verbal substance---technical resources such as pastiche, polyphony, double-folded discourse, intersection of historical consciousnesses, dismembering and grammar rupture.
ZAMONAVIY BADIIY GIMNASTIKADA INNOVATSION USKUNALAR
Creators: name: Farhodova, Maftuna
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqolada zamonaviy badiiy gimnastikada qo'llaniladigan innovatsion uskunalar va ularning sport rivojiga ta'siri o'rganiladi. Tadqiqot natijasida, yangi texnologiyalar va materiallarning kiritilishi gimnastlarning texnik mahoratini va chiqishlarning estetik jozibadorligini sezilarli darajada oshirgani aniqlandi. Shu bilan birga, uskunalarning evolyutsiyasi sport turining o'ziga xos xususiyatlarini saqlab qolgan holda, uning zamonaviy talablarga mosligini ta'minlaydi.