cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
COVID-19 Needs Assessment and Support for Primary Care Practices in Western North Carolina.
Creators: name: Scott, Kacey
name: Denslow, Sheri
name: Hodge, Bryan
name: Fromewick, Jill
name: Mottus, Kathleen
name: Cass, Brian
name: Bossingham, Jesse
name: Halladay, Jacqueline R
name: Richman, Erica L
name: Garrity, Tammy
Publisher: name: HCA Healthcare
Year: 2020

description: Background: It is critical to ensure that Primary Care Providers (PCPs) have adequate personal protective equipment (PPE), supplies, training, staffing, and contingency planning during pandemics, particularly in rural areas. In March 2020, during the onset of the COVID-19 pandemic, the Mountain Area Health Education Center (MAHEC), in collaboration with the Cecil G. Sheps Center for Health Services Research at UNC Chapel Hill, rapidly created and conducted a needs assessment of PCPs in western North Carolina (WNC).
Methods: A group of twenty volunteers conducted a telephone survey of PCPs in a 16 county region of WNC. Practices were asked about their COVID-19 testing and telehealth offerings, PPE adequacy, and capacity to continue serving patients. The survey's emergency alert feature linked practices to immediate support. Descriptive data were generated to identify regional needs.
Results: Out of 110 practices, 48 (43.6%) offered COVID-19 testing, with testing more common in rural counties (56.3% vs 33.9%). Telehealth services, including phone-only visits, were offered by almost all practices (91.8%). PPE needs included N-95 respirators (49.1%), face shields (45.5%), and staff gowns (38.2%). Rural practices were more likely to report the need for PPE. Assistance was requested for staff member childcare (34.5%) and providing or billing for telehealth (31.8%). The most urgent practice requests were related to finances, PPE, and telehealth. MAHEC's Practice Support team linked practices to virtual coaching, tip sheets, case-based video didactics and communication forums, and newsletters.
Conclusion: During a pandemic, it is crucial to ensure that PCPs can continue to serve their patients. A rapid needs assessment of PCPs can allow for immediate and ongoing support that matches regional and practice-specific needs. Rural practices may require more assistance than their urban counterparts. Our rapid survey process jumpstarted a statewide system for enhanced communications with PCPs to better prepare for future emergencies.
Sonnenfleckenzeichnung Nr. 249.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 17.10.2004, 10:30, erstellt von Andrea Manna
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2004

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Gravitational waves and cosmic expansion: similarities and differences
Creators: name: Pössel, Markus
Publisher: name: arXiv
Year: 2017
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Gravitational waves and cosmic expansion are both described in terms of Einstein's general relativity. This article explores the similarities between the two phenomena, as well as some differences, using the fundamental concept of the metric of spacetime, expressed via a line element. In both contexts, the focus is on the metric description of space, as opposed to the components of the metric determining the properties of time. This allows for a simplified, more accessible discussion.
description: 12 pages, 6 figures
title: Iowa Byington Reed diary 01, January 1, 1872-December 31, 1874
Creators: name: Reed, Iowa Byington
Publisher: name: University of Iowa. Libraries
Year: 2012
Subjects: subject: FOS: History and archaeology
valueUri: http://www.oecd.org/science/inno/38235147.pdf
subject: FOS: History and archaeology
subject: Domestic life
valueUri: http://id.loc.gov/vocabulary/graphicMaterials/tgm003216

description: Iowa Byington Reed's diaries contain daily entries covering her life from age twenty to just a few weeks before her death at age eighty-four (1872-1936).
Sonnenfleckenzeichnung Nr. 152.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 01.07.2004, 07:30, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2004

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Exercise Is Medicine® on Campus during COVID-19: Necessary Adaptations and Continuing Importance
Creators: name: Stanford, Kathleen
name: Pomeroy, Alexander
name: Tamminga, Kyle
name: Stoner, Lee
name: Moore, Justin B.
name: Chai, Thevy
name: Brookey, Lindsay
name: Bates, Lauren C.
Publisher: name: Wolters Kluwer
Year: 2020

description: Exercise Is Medicine® on Campus (EIM-OC), created by the American College of Sports Medicine (ACSM), is an initiative connecting college medical providers to exercise providers to better promote physical activity (PA) among students. At the University of North Carolina at Chapel Hill (UNC), PA has been incorporated as a vital sign within the campus health medical system, in which the provider assesses the patient’s current PA. If needed, the provider refers the patient to the UNC EIM-OC team. The UNC EIM-OC initiative began in fall 2016, but it was not until spring 2020 that a fully operational system was in place, and UNC EIM-OC was awarded “gold status” by the ACSM. However, just as the system was running smoothly, the COVID-19 pandemic spread to the United States. COVID-19 and its associated social distancing restrictions have led to many changes in the EIM-OC process. With respect to EIM-OC, this commentary reports on (i) the continuing importance of the initiative during COVID-19, (ii) COVID-related adaptations to UNC EIM-OC, and (iii) recommendations for the upcoming school year.
Redesigning Fellowship Curriculum Amidst The Covid-19 Pandemic: Our Shared Experiences
Creators: name: Cardillo, Serena
name: Guido, Paul
name: Young, Laura
name: White, Caitlin A
Publisher: name: Elsevier
Year: 2020

description: The COVID-19 pandemic has created innumerable
challenges for medical professionals, including the need
to balance clinical obligations with the continued need to
provide a valuable and well-rounded educational experience
for our medical trainees. Indeed, trainees at all levels
have expressed concerns regarding the impact of COVID-
19 on their education (1,2). Given the uncertain duration of
this pandemic, it is important to begin sharing best practices
to optimize trainees’ educational experiences during
this time. Here, we describe curricular changes implemented
in spring 2020 in response to COVID-19 within
our Endocrinology, Diabetes, and Metabolism Fellowship
programs pertaining to clinical care, didactic sessions,
and mentorship structure, as well as our fellows’ feedback
regarding the educational value of these changes. At the time
of publication of this article in August 2020, our fellowship
structure has again been modified to enable more in-person
clinical and learning experiences. However, the regional
variability in COVID-19 cases and dynamic response to
infection control measures underscore the importance of
adaptability in fellowship programs.
Sonnenfleckenzeichnung Nr. 196.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 19.08.2004, 08:30, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2004

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
mTOR inhibition in COVID‐19: A commentary and review of efficacy in RNA viruses
Creators: name: Zolfaghari, Emily J.
name: Tignanelli, Christopher J.
name: Lotfi‐Emran, Sahar
name: Ingraham, Nicholas E.
name: Charles, Anthony
name: Morris, Rachel S.
name: Odde, David J.
name: Bramante, Carolyn T.
name: Puskarich, Michael
name: Karam, Basil S.
Publisher: name: Wiley
Year: 2020

description: In this commentary, we shed light on the role of the mammalian target of rapamycin (mTOR) pathway in viral infections. The mTOR pathway has been demonstrated to be modulated in numerous RNA viruses. Frequently, inhibiting mTOR results in suppression of virus growth and replication. Recent evidence points towards modulation of mTOR in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We discuss the current literature on mTOR in SARS-CoV-2 and highlight evidence in support of a role for mTOR inhibitors in the treatment of coronavirus disease 2019.
Sonnenfleckenzeichnung Nr. 151.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 30.06.2004, 07:30, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2004

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Localization and self-trapping in driven-dissipative polariton condensates
Creators: name: Bello, F.
name: Eastham, P. R.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We study driven-dissipative Bose-Einstein condensates in a two-mode Josephson system, such as a double-well potential, with asymmetrical pumping. We investigate nonlinear effects on the condensate populations and mode transitions. The generalized Gross-Pitaevskii equations are modified in order to treat pumping of only a single mode. We characterize the steady-state solutions in such a system as well as criteria for potential trapping of a condensate mode. There are many possible steady-states, with different density and/or phase profiles. Transitions between different condensate modes can be induced by varying the parameters of the junction or the initial conditions, or by applying external fields.
description: 8 pages, 6 figures. v2: Additional discussion and improved figures
Sonnenfleckenzeichnung Nr. 193.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 15.08.2004, 10:30, erstellt von Andrea Manna
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2004

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Staying ‘in sync’ with others during COVID-19: Perceived positivity resonance mediates cross-sectional and longitudinal links between trait resilience and mental health
Creators: name: Le Nguyen, Khoa D.
name: Wells, Jenna L.
name: Zhou, Jieni
name: West, Taylor N.
name: Fredrickson, Barbara L.
name: Prinzing, Michael M.
Publisher: name: Taylor & Francis
Year: 2020

description: Shared positive emotions involving caring and synchrony – termed ‘positivity resonance’ – are associated with mental health. We hypothesized that, during the COVID-19 pandemic, individual differences in trait resilience would be linked with better overall mental health in part because those higher in trait resilience experience more positivity resonance. We surveyed respondents nationally in April and May of 2020 (total N = 1,059), during pervasive stay-at-home orders. Participants completed self-reports of trait resilience and mental health and used the Day Reconstruction Method to describe their social and emotional experiences. Structural equation models showed perceived positivity resonance to mediate the links between trait resilience and mental health outcomes. Subsequent analyses showed these mediating effects to be independent of overall positive emotion and social interaction quantity (amongst nationwide adults). These results indicate that high-quality social connection played a uniquely important role in maintaining mental health during the COVID-19 pandemic.
Super quantum discord for general two qubit X states
Creators: name: Jing, Naihuan
name: Yu, Bing
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The exact solutions of the super quantum discord are derived for general two qubit X states in terms of a one-variable function. Several exact solutions of the super quantum discord are given for the general X-state over nontrivial regions of a seven dimensional manifold. It is shown that the super quantum discord of the X state may increase or decreases under the phase damping channel.
description: 16 pages, 3 figures
COVID-19 – An Opportunity to Redesign Health Policy Thinking
Creators: name: Tsasis, Peter
name: Sturmberg, Joachim P.
name: Hoemeke, Laura
Publisher: name: Maad Rayan Publishing Company
Year: 2020

description: Coronavirus disease 2019 (COVID-19) dramatically unveiled the fragile state of the world's health and social systems - the lack of emergency health crisis preparedness (under-resourced, weak leadership, strategic plans without clear lines of authority), siloed policy frameworks (focus on individual diseases and the lack of integration of health into the whole of societal activity and its impact on individual as well as community well-being and prosperity), and unclear communication (misguided rationale of policies, inconsistent interpretation of data). The net result is fear - about the disease, about risks and survival, and about economic security. We discuss the interdependencies among these domains and their emergent dynamics and emphasise the need for a robust distributed health system and for transparent communication as the basis for trust in the system. We conclude that systems thinking and complexity sciences should inform the redesign of strong health systems urgently to respond to the current health crisis and over time to build healthy, resilient, and productive communities.
Entrepreneurial Pursuits of Weavers in Low Resource Handloom Industry in South India. Study carried on handloom weavers engaged in silk, silk cotton, cotton saree weaving with Jacquard designs.
Creators: name: Bhupathy, Poongodi
name: Tharani, Monisaa S K
name: Govindan, Ramakrishnan
Publisher: name: figshare
Year: 2022
Subjects: subject: 150304 Entrepreneurship
subject: FOS: Economics and business
subject: 150314 Small Business Management
subject: 210202 Heritage and Cultural Conservation
subject: FOS: Media and communications

description: Primary data is collected from the handloom weavers of select districts in South India . This involves careful selection of factors that influences to take up entrepreneurial journey by the handloom weavers. Handloom Weaving is a low resource industry still largely dependent on the master weavers. The crafts person are largely engaged in a job based order and the profits goes only to the master weavers.
Community modulated recursive trees and population dependent branching processes
Creators: name: Nobel, Andrew
name: Bhamidi, Shankar
name: Fraiman, Nicolas
name: Fan, Ruituo
Publisher: name: Wiley
Year: 2021

description: We consider random recursive trees that are grown via community modulated schemes that involve random attachment or degree based attachment. The aim of this article is to derive general techniques based on continuous time embedding to study such models. The associated continuous time embeddings are not branching processes: individual reproductive rates at each time t depend on the composition of the entire population at that time, and hence vertices do not reproduce independently. Using stochastic analytic techniques we show that various key macroscopic statistics of the continuous time embedding stabilize, allowing asymptotics for a host of functionals of the original models to be derived.
Sonnenfleckenzeichnung Nr. 182.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 03.08.2004, 07:15, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2004

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Consecutive Insulator-Metal-Insulator Phase Transitions of Vanadium Dioxide by Hydrogen Doping
Creators: name: Chen, Shi
name: Wang, Zhaowu
name: Fan, Lele
name: Chen, Yuliang
name: Ren, Hui
name: Ji, Heng
name: Natelson, Douglas
name: Huang, Yingying
name: Jiang, Jun
name: Zou, Chongwen
Publisher: name: arXiv
Year: 2017
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We report modulation of a reversible phase transition in VO2 films by hydrogen doping. A metallic phase and a new insulating phase are successively observed at room temperature as the doping concentration increases. It is suggested that the polarized charges from doped hydrogens play an important role. These charges gradually occupy V3d-O2p hybridized orbitals and consequently modulate the filling of the VO2 crystal conduction band-edge states, which eventually evolve into new valence band-edge states. This demonstrates the exceptional sensitivity of VO2 electronic properties to electron concentration and orbital occupancy, providing key information for the phase transition mechanism.
description: 16 pages, 4 figures
Sonnenfleckenzeichnung Nr. 298.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 19.12.2004, 10:15, erstellt von Andrea Manna
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2004

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3Kα and PI3Kγ
Creators: name: Kuhlman, Brian A
name: Kistler, Samantha K
name: Martinez, Nicholas G
name: Thieker, David F
name: Campbell, Sharon L
name: Carey, Leiah M
name: Rasquinha, Juhi A
Publisher: name: Elsevier
Year: 2021

description: Phosphatidylinositol-3-kinases (PI3Ks) are lipid kinases that phosphorylate phosphatidylinositol 4,5-bisphosphate to generate a key lipid second messenger, phosphatidylinositol 3,4,5-bisphosphate. PI3Kα and PI3Kγ require activation by RAS proteins to stimulate signaling pathways that control cellular growth, differentiation, motility and survival. Intriguingly, RAS binding to PI3K isoforms likely differ, as RAS mutations have been identified that discriminate between PI3Kα and PI3Kγ, consistent with low sequence homology (23%) between their RAS binding domains (RBDs). As disruption of the RAS/PI3Kα interaction reduces tumor growth in mice with RAS- and epidermal growth factor receptor driven skin and lung cancers, compounds that interfere with this key interaction may prove useful as anti-cancer agents. However, a structure of PI3Kα bound to RAS is lacking, limiting drug discovery efforts. Expression of full-length PI3K isoforms in insect cells has resulted in low yield and variable activity, limiting biophysical and structural studies of RAS/PI3K interactions. This led us to generate the first RBDs from PI3Kα and PI3Kγ that can be expressed at high yield in bacteria and bind to RAS with similar affinity to full-length PI3K. We also solved a 2.31 Å X-ray crystal structure of the PI3Kα-RBD, which aligns well to full-length PI3Kα. Structural differences between the PI3Kα and PI3Kγ RBDs are consistent with differences in thermal stability and may underly differential RAS recognition and RAS-mediated PI3K activation. These high expression, functional PI3K RBDs will aid in interrogating RAS interactions and could aid in identifying inhibitors of this key interaction.
Fabrication d’une cigale. Jean Estirach taille un roseau, tube qui formera la caisse de résonance
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2022

Abstract
Sonnenfleckenzeichnung Nr. 30.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 06.02.2004, 08:30, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2004

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Some geometric properties of Read's space
Creators: name: Kadets, Vladimir
name: Lopez, Gines
name: Martin, Miguel
Publisher: name: arXiv
Year: 2017
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 46B04 (Primary), 46B03, 46B20 (Secondary)

description: We study geometric properties of the Banach space $\mathcal{R}$ constructed recently by C.~Read (arXiv 1307.7958) which does not contain proximinal subspaces of finite codimension greater than or equal to two. Concretely, we show that the bidual of $\mathcal{R}$ is strictly convex, that the norm of the dual of $\mathcal{R}$ is rough, and that $\mathcal{R}$ is weakly locally uniformly rotund (but it is not locally uniformly rotund). Apart of the own interest of the results, they provide a simplification of the proof by M.~Rmoutil (J.\ Funct.\ Anal.\ 272 (2017), 918--928) that the set of norm-attaining functionals over $\mathcal{R}$ does not contain any linear subspace of dimension greater than or equal to two. Note that if a Banach space $X$ contains proximinal subspaces of finite codimension at least two, then the set of norm-attaining functionals over $X$ contain two-dimensional linear subspaces of $X^*$. Our results also provides positive answer to the questions of whether the dual of $\mathcal{R}$ is smooth and of whether $\mathcal{R}$ is weakly locally uniformly rotund (J.\ Funct.\ Anal.\ 272 (2017), 918--928). Finally, we present a renorming of Read's space which is smooth, whose dual is smooth, and such that its set of norm-attaining functionals does not contain any linear subspace of dimension greater than or equal to two, so the renormed space does not contain proximinal subspaces of finite codimension greater than or equal to two.
description: To appear in the Journal of Functional Analysis; 10 pages; a couple of new results added
Sonnenfleckenzeichnung Nr. 191.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 13.08.2004, 07:30, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2004

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Defining Stable Reference Genes in HIV Latency Reversal Experiments
Creators: name: Margolis, David M.
name: Streeter, Gabrielle S.
name: Lemu, Kena J.
name: Allard, Brigitte
name: James, Katherine S.
name: Archin, Nancie M.
name: Ceriani, Cristina
name: Shook-Sa, Bonnie E.
name: Ghofrani, Simon
Publisher: name: American Society for Microbiology
Year: 2021

description: Quantification of cell associated HIV RNA (ca-RNA) is one of the most important and commonly used methods to evaluate the performance of latency-reversing agents (LRAs). Copies of HIV RNA measured by qPCR, are often normalized to the input RNA or cell number. However, these could be affected by biological variability and/or technical errors, which can be avoided by using an internal reference gene. To obtain reliable data, it is essential to select stable reference genes (RGs) of which the expression is not influenced by biological variability, the type of cells, or the LRAs used. However, to date, no study has carefully evaluated RG stability following LRA exposure. We analyzed the stability of six widely used RGs (GAPDH, TBP, YWHAZ, UBE2D2, HPRT1 and RPL27A) in human PBMC and CD4+ T cells. LRA exposure significantly influenced the stability of these RGs. Overall, TBP, UBE2D2, and RPL27A were the most stable RGs in all tested conditions. TBP was generally the most stable RG whereas GAPDH varied the most. Finally, we evaluated the impact of applying different RG normalizers to host genes and HIV ca-RNA data. Altered results were observed both in host and HIV gene expression when unstable RGs were used. Our data underline the importance of testing the stability of RGs utilized to evaluate LRA-induced HIV ca-RNA expression. To our knowledge, this is the first careful evaluation of the stability of RGs after LRA exposure and will significantly contribute to the quality of data analysis in regard to gene expression.IMPORTANCE Latency-reversing agents (LRAs) are ubiquitously used in the "shock-and-kill" HIV cure strategy and their performance is often evaluated by ex-vivo quantification of cell associated HIV RNA. HIV RNA, measured by qPCR, is often normalized to internal reference genes, but the expression of these genes should not be influenced by the experimental settings. We found that treatment of human PBMC and CD4+ T cells with LRAs significantly altered the expression of several commonly used reference genes, such as GAPDH. Finally, we evaluate the impact of different reference genes on normalization of host genes and HIV cell associated RNA expression and demonstrated that using unstable reference genes dramatically altered experimental outcome. Our data highlight the importance of using reference genes that are unaffected by LRAs under study to correctly evaluate host gene and cell associated HIV RNA expression induced by latency-reversing agents.
Sonnenfleckenzeichnung Nr. 236.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 30.09.2004, 07:15, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2004

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Sonnenfleckenzeichnung Nr. 97.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 29.04.2004, 07:00, erstellt von Elena Altoni
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2004

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
High quality waveguides for the mid-infrared wavelength range in a silicon-on-sapphire platform
Creators: name: Li, Fangxin
name: Jackson, Stuart D.
name: Grillet, Christian
name: Magi, Eric
name: Hudson, Darren
name: Madden, Steven J.
name: Moghe, Yashodhan
name: OBrien, Christopher
name: Read, Andrew
name: Duvall, Steven G.
name: Atanackovic, Peter
name: Eggleton, Benjamin J.
name: Moss, David J.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Applied Physics (physics.app-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We report record low loss silicon-on-sapphire nanowires for applications to mid infrared optics. We achieve propagation losses as low as 0.8dB/cm at 1550nm, 1.1 to 1.4dB/cm at 2080nm and < 2dB/cm at = 5.18 microns.
description: 9 pages, 6 figures, 18 references
A Missed Opportunity? Instructional Content Redundancy in Pre-K and Kindergarten
Creators: name: Little, Michael
name: Jang, Wonkyung
name: Cohen-Vogel, Lora
name: Bratsch-Hines, Mary
name: Burchinal, Margaret
Publisher: name: SAGE Publications
Year: 2021

description: Policy observers have expressed concern over whether misalignment between pre-K and K–12 has negative consequences for children. This study considers students’ exposure to redundant content across the pre-K and kindergarten years. Specifically, it asks, to what extent are skills and concepts taught in kindergarten redundant with skills and concepts taught in one state’s public pre-K program, and for whom is redundancy most likely? Overall, findings from teacher surveys show that about 37% of the language, literacy, and math content covered in kindergarten is redundant with content covered in pre-K. The highest rates of redundancy seem to occur for basic (rather than advanced) content items, including the identification of letters and sight words. Moreover, children from families who live at or below the poverty line experience significantly higher rates of redundant content. Implications for policy, practice, and future research are discussed.
Sonnenfleckenzeichnung Nr. 247.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 13.10.2004, 11:30, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2004

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Nonclassical and semiclassical para-Bose states
Creators: name: Alderete, C. Huerta
name: Vergara, Liliana Villanueva
name: Rodríguez-Lara, B. M.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Motivated by the proposal to simulate para-Bose oscillators in a trapped-ion setup [C. Huerta Alderete and B. M. Rodríguez-Lara, Phys. Rev. A 95, 013820 (2017)], we introduce an overcomplete, nonorthogonal basis for para-Bose Hilbert spaces. The states spanning these bases can be experimentally realized in the trapped-ion simulation via time evolution. The para-Bose states show both nonclassical and semiclassical statistics on their Fock state distribution, asymmetric field quadrature variances, and do not minimize the uncertainty relation for the field quadratures. These properties are analytically controlled by the para-Bose order and the evolution time; both parameters might be feasible for fine tuning in the trapped-ion quantum simulation.
description: 16 pages, 5 figures
Epigenomic characterization of latent HIV infection identifies latency regulating transcription factors
Creators: name: Selitsky, Sara R.
name: Coffey, Alisha R.
name: Parker, Joel
name: Burgos, Samuel D.
name: Turner, Anne-Marie
name: Browne, Edward P.
name: James, Lindsey I.
name: Tsai, Yi-Hsuan
name: Peterson, Jackson J.
name: Jefferys, Stuart R.
name: Margolis, David M.
Publisher: name: Public Library of Science (PLoS)
Year: 2021

description: Transcriptional silencing of HIV in CD4 T cells generates a reservoir of latently infected cells that can reseed infection after interruption of therapy. As such, these cells represent the principal barrier to curing HIV infection, but little is known about their characteristics. To further our understanding of the molecular mechanisms of latency, we characterized a primary cell model of HIV latency in which infected cells adopt heterogeneous transcriptional fates. In this model, we observed that latency is a stable, heritable state that is transmitted through cell division. Using Assay of Transposon-Accessible Chromatin sequencing (ATACseq) we found that latently infected cells exhibit greatly reduced proviral accessibility, indicating the presence of chromatin-based structural barriers to viral gene expression. By quantifying the activity of host cell transcription factors, we observe elevated activity of Forkhead and Kruppel-like factor transcription factors (TFs), and reduced activity of AP-1, RUNX and GATA TFs in latently infected cells. Interestingly, latency reversing agents with different mechanisms of action caused distinct patterns of chromatin reopening across the provirus. We observe that binding sites for the chromatin insulator CTCF are highly enriched in the differentially open chromatin of infected CD4 T cells. Furthermore, depletion of CTCF inhibited HIV latency, identifying this factor as playing a key role in the initiation or enforcement of latency. These data indicate that HIV latency develops preferentially in cells with a distinct pattern of TF activity that promotes a closed proviral structure and inhibits viral gene expression. Furthermore, these findings identify CTCF as a novel regulator of HIV latency.
A General Approach for Predicting the Behavior of the Supreme Court of the United States
Creators: name: Katz, Daniel Martin
name: Bommarito, Michael J
name: Blackman, Josh
Publisher: name: arXiv
Year: 2016
Subjects: subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences

description: Building on developments in machine learning and prior work in the science of judicial prediction, we construct a model designed to predict the behavior of the Supreme Court of the United States in a generalized, out-of-sample context. To do so, we develop a time evolving random forest classifier which leverages some unique feature engineering to predict more than 240,000 justice votes and 28,000 cases outcomes over nearly two centuries (1816-2015). Using only data available prior to decision, our model outperforms null (baseline) models at both the justice and case level under both parametric and non-parametric tests. Over nearly two centuries, we achieve 70.2% accuracy at the case outcome level and 71.9% at the justice vote level. More recently, over the past century, we outperform an in-sample optimized null model by nearly 5%. Our performance is consistent with, and improves on the general level of prediction demonstrated by prior work; however, our model is distinctive because it can be applied out-of-sample to the entire past and future of the Court, not a single term. Our results represent an important advance for the science of quantitative legal prediction and portend a range of other potential applications.
description: version 2.02; 18 pages, 5 figures. This paper is related to but distinct from arXiv:1407.6333, and the results herein supersede arXiv:1407.6333. Source code available at https://github.com/mjbommar/scotus-predict-v2
Sonnenfleckenzeichnung Nr. 230.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 24.09.2004, 11:45, erstellt von Michele Bianda
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2004

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Concurrent Inhibition of IGF1R and ERK Increases Pancreatic Cancer Sensitivity to Autophagy InhibitorsIGF1R Inhibition Enhances Dual ERK and Autophagy Inhibition
Creators: name: Coleman, Michael F.
name: Yang, Runying
name: Wennerberg, Krister
name: Hursting, Stephen D.
name: Goodwin, Craig M.
name: Grover, Kajal R.
name: Papke, Björn
name: Stalnecker, Clint A.
name: Der, Channing J.
name: Gautam, Prson
name: Petricoin, Emanuel F.
name: DeLiberty, Jonathan M.
name: Bryant, Kirsten L.
name: Pierobon, Mariaelena
name: Cox, Adrienne D.
name: Edwards, A. Cole
Publisher: name: American Association for Cancer Research (AACR)
Year: 2021

description: The aggressive nature of pancreatic ductal adenocarcinoma (PDAC) mandates the development of improved therapies. As KRAS mutations are found in 95% of PDAC and are critical for tumor maintenance, one promising strategy involves exploiting KRAS-dependent metabolic perturbations. The macrometabolic process of autophagy is upregulated in KRAS-mutant PDAC, and PDAC growth is reliant on autophagy. However, inhibition of autophagy as monotherapy using the lysosomal inhibitor hydroxychloroquine (HCQ) has shown limited clinical efficacy. To identify strategies that can improve PDAC sensitivity to HCQ, we applied a CRISPR-Cas9 loss-of-function screen and found that a top sensitizer was the receptor tyrosine kinase (RTK) insulin-like growth factor 1 receptor (IGF1R). Additionally, reverse phase protein array pathway activation mapping profiled the signaling pathways altered by chloroquine (CQ) treatment. Activating phosphorylation of RTKs, including IGF1R, was a common compensatory increase in response to CQ. Inhibition of IGF1R increased autophagic flux and sensitivity to CQ-mediated growth suppression both in vitro and in vivo. Cotargeting both IGF1R and pathways that antagonize autophagy, such as ERK-MAPK axis, was strongly synergistic. IGF1R and ERK inhibition converged on suppression of glycolysis, leading to enhanced dependence on autophagy. Accordingly, concurrent inhibition of IGF1R, ERK, and autophagy induced cytotoxicity in PDAC cell lines and decreased viability in human PDAC organoids. In conclusion, targeting IGF1R together with ERK enhances the effectiveness of autophagy inhibitors in PDAC.
SIGNIFICANCE: Compensatory upregulation of IGF1R and ERK-MAPK signaling limits the efficacy of autophagy inhibitors chloroquine and hydroxychloroquine, and their concurrent inhibition synergistically increases autophagy dependence and chloroquine sensitivity in pancreatic ductal adenocarcinoma.
Sonnenfleckenzeichnung Nr. 129.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 06.06.2004, 08:15, erstellt von Andrea Manna
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2004

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Surfactant films in lyotropic lamellar (and related) phases: Fluctuations and interactions
Creators: name: Nallet, Frédéric
Publisher: name: arXiv
Year: 2017
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: The analogy between soap films thinning under border capillary suction and lamellar stacks of surfactant bilayers dehydrated by osmotic stress is explored, in particular in the highly dehydrated limit where the soap film becomes a Newton black film. The nature of short-range repulsive interactions between surfactant-covered interfaces and acting across water channels in both cases will be discussed.
description: 29 pages, 11 figures. Accepted for publication (2017/06/21), Advances in Colloid and Interface Science
Emergency department visits among patients transported by law enforcement officers
Creators: name: Travers, Debbie
name: Rosen, David L.
Publisher: name: Public Library of Science (PLoS)
Year: 2021

description: Law enforcement officers frequently encounter people with health conditions. We sought to estimate the rates, diagnoses, and characteristics of emergency department (ED) visits among patients transported directly by law enforcement. We analyzed statewide North Carolina Emergency Department data for adults, aged 18+ years, from 2009 to 2016. We estimated transport rates using census data; categorized primary ED diagnoses into 13 major and 8 substituent categories; compared county transport rates by rurality; and examined patient characteristics. There were 136,240 patients transported by law enforcement; annual rates increased from 186.9 (per 100,000 adult residents) in 2009 to 279.2 in 2016. Among visits, 67.7% were among men, the median age was 37 years, and 20.4% resulted in a hospital admission. Most common primary diagnoses were Mental Health Diagnoses (43.1%)-including Schizophrenia and other Psychotic Disorders (7.6%), Mood Disorders (9.7%), and Alcohol and Substance Use (10.7%)-followed by Injury and Poisoning (12.4%) and Circulatory conditions (4.1%). Involuntary commitments constituted 22% of all visits. The median transport rate in rural counties, 291.1, was 2 times that of large metro counties, 145.1. The visit rate increased by nearly 50% during the study period, with the highest rates in rural counties. Many transports were for Mental Illness and involuntary commitments. The relatively common occurrence of law enforcement transports suggests the need for greater research to understand factors influencing law enforcement transport decisions, the impact of these transports on patient health and safety, and the repercussions on patient care of a growing officer presence in EDs.
Sonnenfleckenzeichnung Nr. 25.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 01.02.2004, 10:15, erstellt von Andrea Manna
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2004

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)