title: Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð½Ð°Ð½Ð¾Ð½Ð¾ÑÐ¸ÑÐµÐ»ÐµÐ¹ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ½Ð¾Ð³Ð¾ ÑÐ¾ÑÑÐ°Ð²Ð° Ñ ÑÐµÐ»ÑÑ Ð²ÐºÐ»ÑÑÐµÐ½Ð¸Ñ ÑÐµÑÐ°Ð¿ÐµÐ²ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ð° Ð°ÐºÑÐ¸Ð½Ð¸Ñ-225 Ð¸ ÑÐ´ÐµÑÐ¶Ð°Ð½Ð¸Ñ ÐµÐ³Ð¾ Ð´Ð¾ÑÐµÑÐ½Ð¸Ñ Ð¸Ð·Ð¾ÑÐ¾Ð¿Ð¾Ð²
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Development of nanocarriers of complex composition with the aim of incorporating the therapeutic radionuclide actinium-225 and retaining its daughter isotopes
Creators: name: ÐÐ°ÑÐ¿Ð¾Ð², Ð¢Ð¸Ð¼Ð¾ÑÐµÐ¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2021
Subjects: ÐÐ°Ð½Ð¾ÑÑÑÑÐºÑÑÑÐ½ÑÐµ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ñ
Ð Ð°Ð´Ð¸Ð¾Ð°ÐºÑÐ¸Ð²Ð½ÑÐµ Ð¸Ð·Ð¾ÑÐ¾Ð¿Ñ
ÑÐ°Ð´Ð¸Ð¾ÑÐµÑÐ°Ð¿Ð¸Ñ
Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸ÑÑ
ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ñ
Ð°Ð»ÑÑÐ°-Ð¸Ð·Ð»ÑÑÐµÐ½Ð¸Ðµ
Ð±ÐµÑÐ°-Ð¸Ð·Ð»ÑÑÐµÐ½Ð¸Ðµ
ÑÐ¸Ð»Ð¸ÐºÐ°
ÑÐ¸ÑÐ°Ð½
Ð·Ð¾Ð»Ð¾ÑÐ¾

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐµ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ð¹ ÑÐ¸Ð½ÑÐµÐ·Ð° ÑÑÐµÑÐ¸ÑÐµÑÐºÐ¸Ñ SiO2 Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸Ñ, Ð¼Ð¾Ð´Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¸ Ð¸Ñ Ð¿Ð¾Ð²ÐµÑÑÐ½Ð¾ÑÑÐ¸ Ð¼ÐµÑÐ°Ð»Ð»Ð¸ÑÐµÑÐºÐ¸Ð¼Ð¸ Ð¾Ð±Ð¾Ð»Ð¾ÑÐºÐ°Ð¼Ð¸ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð±ÑÑÐ¾ÐºÑÐ¸Ð´Ð° ÑÐ¸ÑÐ°Ð½Ð° Ð¸ ÑÐµÑÑÐ°ÑÐ»Ð¾ÑÐ¾Ð°ÑÑÐ°ÑÐ° Ð²Ð¾Ð´Ð¾ÑÐ¾Ð´Ð° Ð¸ ÑÐ´ÐµÑÐ¶Ð°Ð½Ð¸Ñ ÑÐ°ÑÑÐ¸ÑÐ°Ð¼Ð¸ ÑÐ°Ð´Ð¸Ð¾Ð°ÐºÑÐ¸Ð²Ð½ÑÑ Ð¸Ð·Ð¾ÑÐ¾Ð¿Ð¾Ð² Ð°ÐºÑÐ¸Ð½Ð¸Ñ-225, ÑÑÐ°Ð½ÑÐ¸Ñ-221 Ð¸ Ð²Ð¸ÑÐ¼ÑÑÐ°-213 Ð² ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ñ in vitro Ð¸ in vivo. ÐÐ°Ð´Ð°ÑÐ¸, ÑÐµÑÐ°ÐµÐ¼ÑÐµ Ð² ÑÐ¾Ð´Ðµ ÑÐµÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¿ÑÐ¾ÐµÐºÑÐ°: 1. Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ð¹ ÑÐ¸Ð½ÑÐµÐ·Ð° ÑÐ¸Ð»Ð¸ÐºÐ°ÑÐ½ÑÑ ÑÐ°ÑÑÐ¸Ñ Ñ Ð¿Ð¾ÑÐ»ÐµÐ´Ð¾Ð²Ð°ÑÐµÐ»ÑÐ½ÑÐ¼ Ð²ÐºÐ»ÑÑÐµÐ½Ð¸ÐµÐ¼ Ð² Ð¸Ñ ÑÑÑÑÐºÑÑÑÑ ÑÐ°Ð´Ð¸Ð¾Ð°ÐºÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð¸Ð·Ð¾ÑÐ¾Ð¿Ð° ÐÐºÑÐ¸Ð½Ð¸Ñ-225. 2. ÐÐ¾Ð´Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ñ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½Ð¾Ð³Ð¾ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ° Ð¼ÐµÑÐ°Ð»Ð»Ð¸ÑÐµÑÐºÐ¸Ð¼Ð¸ Ð¾Ð±Ð¾Ð»Ð¾ÑÐºÐ°Ð¼Ð¸ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð±ÑÑÐ¾ÐºÑÐ¸Ð´Ð° ÑÐ¸ÑÐ°Ð½Ð° Ð¸ ÑÐµÑÑÐ°ÑÐ»Ð¾ÑÐ¾Ð°ÑÑÐ°Ñ(III) Ð²Ð¾Ð´Ð¾ÑÐ¾Ð´Ð°. 3. Ð¥Ð°ÑÐ°ÐºÑÐµÑÐ¸Ð·Ð°ÑÐ¸Ñ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ Ð½Ð¾ÑÐ¸ÑÐµÐ»ÐµÐ¹ Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ ÑÐ¸Ð·Ð¸ÐºÐ¾-ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ¸Ñ Ð¼ÐµÑÐ¾Ð´Ð¾Ð². 4. ÐÐ¾Ð»Ð¸ÑÐµÑÑÐ²ÐµÐ½Ð½Ð°Ñ Ð¾ÑÐµÐ½ÐºÐ° ÑÐ°Ð´Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ Ð½Ð¾ÑÐ¸ÑÐµÐ»ÐµÐ¹ ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ð¾Ð² Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð´Ð¾Ð·Ð¸Ð¼ÐµÑÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¸ Ð°Ð½Ð°Ð»Ð¸ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¾Ð±Ð¾ÑÑÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ. 5. ÐÐ·ÑÑÐµÐ½Ð¸Ðµ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð½Ð¾ÑÐ¸ÑÐµÐ»ÐµÐ¹ Ð½Ð° ÑÐºÐ°Ð½Ð¸ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð¼Ð° Ð² in vitro Ð¸ in vivo Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸ÑÑ. Ð Ð°Ð±Ð¾ÑÐ° Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð° Ð½Ð° Ð±Ð°Ð·Ðµ Ð ÐÐ¦Ð Ð¥Ð¢ Ð¸Ð¼. Ð. Ð. ÐÑÐ°Ð½Ð¾Ð²Ð° Ð¸ Ð¡ÐÐÐÐ£ Ð¸Ð¼. ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾, Ð³Ð´Ðµ Ð±ÑÐ»Ð¾ ÑÐ¾Ð±ÑÐ°Ð½Ð° Ð±Ð¾Ð»ÑÑÐ°Ñ ÑÐ°ÑÑÑ ÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ð°: ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¿ÑÐ¾ÑÐ¾ÐºÐ¾Ð»Ð¾Ð² ÑÐ¸Ð½ÑÐµÐ·Ð° Ð²ÑÐµÑ ÑÐ¸Ð¿Ð¾Ð² Ð½Ð¾ÑÐ¸ÑÐµÐ»ÐµÐ¹ Ð¸ Ð°Ð´ÑÐ¾ÑÐ±ÑÐ¸Ð¸ ÑÐ°Ð´Ð¸Ð¾Ð°ÐºÑÐ¸Ð²Ð½ÑÑ Ð¸Ð·Ð¾ÑÐ¾Ð¿Ð¾Ð². ÐÑÐ»Ð¸ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ñ ÑÐ°Ð´Ð¸Ð¾ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¿Ð¾ ÑÐ´ÐµÑÐ¶Ð°Ð½Ð¸Ñ ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ð¾Ð² Ð² Ð¿Ð¾Ð»Ð¾ÑÑÐ¸ ÑÐ°ÑÑÐ¸Ñ Ð² in vitro Ð¸ in vivo ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ñ. Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð±ÑÐ»Ð¸ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ñ Ð½Ð¾ÑÐ¸ÑÐµÐ»Ð¸ Ð½Ð° Ð±Ð°Ð·Ðµ SiO2 Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸Ñ, Ð¿Ð¾ÐºÑÑÑÑÐµ ÑÐ¸ÑÐ°Ð½Ð¾Ð²Ð¾Ð¹ Ð¸ Ð·Ð¾Ð»Ð¾ÑÐ¾Ð¹ Ð¾Ð±Ð¾Ð»Ð¾ÑÐºÐ°Ð¼Ð¸. ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð° Ð¿Ð¾Ð»Ð½Ð°Ñ ÑÐ¸Ð·Ð¸ÑÐµÑÐºÐ°Ñ Ð¸ ÑÐ°Ð´Ð¸Ð¾ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ°Ñ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸ÐºÐ° Ð¾Ð±ÑÐ°Ð·ÑÐ¾Ð². ÐÐ·ÑÑÐµÐ½Ð° ÑÑÐµÐ¿ÐµÐ½Ñ ÑÐ´ÐµÑÐ¶Ð°Ð½Ð¸Ñ ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ð¾Ð² Ð¸ ÑÑÐµÐ¿ÐµÐ½Ñ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ° Ð½Ð° Ð¶Ð¸Ð²ÑÐµ ÑÐºÐ°Ð½Ð¸ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð¼Ð¾Ð².
description: This work is devoted to the development of technologies for the synthesis of spherical SiO2 nanoparticles, modification of their surface with metal shells based on titanium butoxide and hydrogen tetrachloroaurate, and the retention of radioactive isotopes of actinium-225, france-221 and bismuth-213 by particles in in vitro and in vivo experiments. Tasks to be solved during the project: 1. Development of technologies for the synthesis of silicate particles with the sequential inclusion of the radioactive isotope Actinium-225 into their structure. 2. Modification of the resulting complex with metal shells based on titanium butoxide and hydrogen tetrachloroaurate (III). 3. Characterization of the obtained carriers using physicochemical methods. 4. Quantitative assessment of the radiological activity of the received carriers of radionuclides using dosimetry and analytical equipment. 5. Study of the effect of carriers on body tissues in in vitro and in vivo studies. The work was carried out on the basis of the N.N. A.M. Granov and St. Peter the Great, where most of the factual material was collected: the development of proto-cols for the synthesis of all types of carriers and the adsorption of radioactive isotopes. Radiochemical studies have been carried out on the retention of radionuclides in the particle cavity in in vitro and in vivo experiments. As a result, supports were developed based on SiO2 nanoparticles covered with titanium and gold shells. The complete physical and radiochemical characteristics of the samples have been carried out. The degree of retention of radionuclides and the degree of influence of the complex on the living tissues of organisms have been studied.