cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Financial Analysis of a Solar Mini Grid  Power Plant Deployment in Kavumu,  DRC: A FINPLAN-Based Approach
Creators: name: Josue, Mugisho Mugaruka
Publisher: name: Zenodo
Year: 2025
Subjects: Financial analysis
Mini grid, Solar Power Plant
DRC
Kavumu

description: This report assesses a proposed 30 MW solar mini-grid in Kavumu, DRC using the financial model FINPLAN. The goal was to test project least profitability under varying conditions. The base case uses the current SNEL tariff (194.4 CDF/kWh), assumes production of 125 GWh per year, an exchange rate of 2840 CDF per USD, a discount rate of 17% and an interest rate of 5%.

Key results show that high utilization is essential: if output drops below ~80% of capacity, the net present value turns negative. Under base assumptions, the project only becomes profitable at ~80% utilization and above. However, even with moderate tariff adjustments (e.g. 10% price cuts), the project remains viable if demand stays high. Financing conditions matter too: the model indicates viability only if discount rates stay below about 17%; higher financing costs would make the NPV negative.

Crucially, the analysis highlights currency risk. With DRC’s double-digit inflation, fixed CDF pricing would increase profitability risks. Our findings show that a small franc devaluation (1%) makes the project financial unviable if the tariff is in CDF. By pricing or indexing the tariff in USD, however, the project’s revenue stream becomes stable to local inflation and exchange shift.

In summary, the solar mini-grid can help expand affordable electricity access in the region, but its financial success depends on robust utilization capacity and smart risk management. Allowing USD-indexed tariffs and supporting productive electricity uses are key policy steps to make this renewable energy investment attractive and sustainable.
Status quo of ALK testing in lung cancer: results of an EQA scheme based on in-situ hybridization, immunohistochemistry, and RNA/DNA sequencing
Creators: name: Jurmeister, Philipp
name: Vollbrecht, Claudia
name: Jöhrens, Korinna
name: Aust, Daniela
name: Behnke, Anke
name: Stenzinger, Albrecht
name: Penzel, Roland
name: Endris, Volker
name: Schirmacher, Peter
name: Fisseler-Eckhoff, Annette
name: Neumann, Jens
name: Kirchner, Thomas
name: Büttner, Reinhard
name: Merkelbach-Bruse, Sabine
name: Kreipe, Hans
name: Jonigk, Danny
name: Jochum, Wolfram
name: Rodriguez, Regulo
name: Dietel, Manfred
name: Horst, David
name: Hummel, Michael
name: Laffert, Maximilian Von
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Non-small cell lung cancer
subject: Anaplastic lymphoma kinase
subject: External quality assessment
subject: Round robin
subject: Next-generation sequencing
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: With this external quality assessment (EQA) scheme, we aim to investigate the diagnostic performance of the currently available methods for the detection of ALK alterations in non-small cell lung cancer on a national scale, namely, in situ hybridization (ISH), immunohistochemistry (IHC), and RNA/DNA sequencing (NGS). The EQA scheme cohort consisted of ten specimens, including four ALK positive and six ALK negative samples, which were thoroughly pretested using IHC, ISH, and RNA/DNA NGS. Unstained tumor sections were provided to the 57 participants, and the results were retrieved via an online questionnaire. ISH was used by 29, IHC by 38, and RNA/DNA sequencing by 19 participants. Twenty-eight institutions (97%) passed the ring trial using ISH, 33 (87%) by using IHC, and 18 (95%) by using NGS. The highest sensitivity and interrater agreement (Fleiss ' kappa) was observed for RNA/DNA sequencing (99%, 0.975), followed by ISH (94%, 0.898) and IHC (92%, 0.888). However, the proportion of samples that were not evaluable due to bad tissue quality was also higher for RNA/DNA sequencing (4%) compared with ISH (0.7%) and IHC (0.5%). While all three methods produced reliable results between the different institutions, the highest sensitivity and concordance were observed for RNA/DNA sequencing. These findings encourage the broad implementation of this method in routine diagnostic, although the application might be limited by technical capacity, economical restrictions, and tissue quality of formalin-fixed samples.
The subjective knee value is a valid single-item survey to assess knee function in common knee disorders
Creators: name: Plachel, Fabian
name: Jung, Tobias
name: Bartek, Benjamin
name: Rüttershoff, Katja
name: Perka, Carsten
name: Gwinner, Clemens
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: PROM
subject: Subjective knee value
subject: Knee function
subject: Knee disorder
subject: Evaluation
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Introduction: The patient's perspective plays a key role in judging the effect of knee disorders on physical function. We have introduced the Subjective Knee Value (SKV) to simplify the evaluation of individual's knee function by providing one simple question. The purpose of this prospective study was to validate the SKV with accepted multiple-item knee surveys across patients with orthopaedic knee disorders. Materials and methods: Between January through March 2020, consecutive patients (n = 160; mean age 51 +/- 18 years, range from 18 to 85 years, 54% women) attending the outpatient clinic for knee complaints caused by osteoarthritis (n = 69), meniscal lesion (n = 45), tear of the anterior cruciate ligament (n = 23) and focal chondral defect (n = 23) were invited to complete a knee-specific survey including the SKV along with the Knee Injury Osteoarthritis Outcome Score (KOOS) and the International Knee Documentation Committee subjective knee form (IKDC-S). The Pearson correlation coefficient was used to evaluate external validity between the SKV and each patient-reported outcome measure (PROM) separately. Furthermore, patient's compliance was assessed by comparing responding rates. Results: Overall, the SKV highly correlated with both the KOOS (R = 0.758, p < 0.05) and the IKDC-S (R = 0.802, p < 0.05). This was also demonstrated across all investigated diagnosis- and demographic-specific (gender, age) subgroups (range 0.509-0.936). No relevant floor/ceiling effects were noticed. The responding rate for the SKV (96%) was significantly higher when compared with those for the KOOS (81%) and the IKDC-S (83%) (p < 0.05). Conclusion: At baseline, the SKV exhibits acceptable validity across all investigated knee-specific PROMs in a broad patient population with a wide array of knee disorders. The simplified survey format without compromising the precision to evaluate individual's knee function justifies implementation in daily clinical practice. Level of evidence II, cohort study (diagnosis).
Musculature adaption in patients with lumbosacral transitional vertebrae: a matched-pair analysis of 46 patients
Creators: name: Becker, Luis
name: Ziegeler, Katharina
name: Diekhoff, Torsten
name: Palmowski, Yannick
name: Pumberger, Matthias
name: Schömig, Friederike
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Transitional
subject: Adaptation
subject: Atrophy
subject: Asymmetry
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objective: Even though lumbosacral transitional vertebrae (LSTV) are one of the most common congenital anomalies of the spine, their effect on surrounding soft tissues is not well-studied. We therefore aimed at analyzing the association between LSTV and changes in volume, mass, symmetry, and degeneration of lumbar and trunk muscles. Materials and methods: Abdomen-pelvis CT scans were analyzed in patients with LSTV and a matched control group. LSTV were classified according to the Castellvi classification. Muscles were segmented from the remaining soft tissue and their cross-sectional area and volume were examined at five defined levels. Threshold segmentation was used to differentiate between muscle fibers and fat tissue. Matched pairs were compared using Wilcoxon rank sum tests. For comparison of categorical data, chi-squared tests were performed and for associations between the degree of fusion and muscle size and degeneration, Spearman's correlation coefficients were calculated. Inter- and intrarater reliabilities were evaluated by computing intraclass correlation coefficients. Results: Forty-six patients with LSTV and 46 controls were included. Muscle volume of the paraspinal and trunk muscles was significantly lower (707.0 cm(3) vs. 809.7 cm(3), p < 0.001) and fatty muscle changes were significantly increased in all but the caudal paravertebral muscles of LSTV patients (M. psoas p < 0.04, M. quadratus lumborum p < 0.001, paravertebral muscles p = 0.011, M. rectus abdominis p < 0.001, M. obliquus abdominis p < 0.001). Correlations between the degree of Castellvi classification and muscle volume were significant (p = 0.001). Conclusion: LSTV are associated with a reduction in muscle volume and an increase in muscle degeneration of both lumbar and trunk muscles.
title: Memo: Linsenmeyer to Board of Trustees of Reston, VA Foundation for Community Programs, Inc., November 14, 1967
Creators: name: Linsenmeyer, J.C.
Publisher: name: George Mason University
Year: 2006

description: Original with black signature and date stamp in upper right, 11" x 8.5" (29.7 cm x 21.6 cm)
description: Memo to Board of Trustees of Reston, VA Foundation for Community Programs, Inc. from J.C. Linsenmeyer (Chairman The Reston Foundation), November 14, 1967. Linsenmeyer discusses the outcome of the previous meetings and the decisions reached, including the costs involved with the HUD Low-Cost Housing Research Project and the transfer of administrative duties. Planned Community Archives Collection, 448.14.
title: A Case Study of Operation Cast Lead: Understanding Israeli Chosen Trauma to Explain the Principle of Proportionality Employed in the Intervention
Creators: name: Formosa, Gordon
Publisher: name: George Mason University
Year: 2014
Subjects: subject: Israel
subject: Hamas
subject: Identity
subject: Gaza

description: This dissertation investigates the relationship between the application of proportionality employed in the December 27, 2008 – January 18, 2009 Israeli military intervention known as Operation Cast Lead, carried out in Gaza, and the large-group psycho-political concept known as chosen trauma. Thus this study probes the effect the latter concept played in the outcome of proportionality used by the Israeli military in Gaza against Hamas. The first chapter in this study will supply the general tenets with which the rest of the study shall deal. This will include definitions of proportionality in international humanitarian law, large-group psychology and chosen trauma. Furthermore this introduction shall also give the reader the motivation for carrying it out, aim of the study, postulation of hypotheses and initial research question. The research question revolves around the premise of ascertaining what role historical anxieties have had in modulating the application of proportionality employed by Israel. The second chapter will deal with xi the methodological aspects of the study, in which a thorough discussion of discourse analysis, the reasons for choosing such methodology and its merits and limitations will be tackled. Chapter three consists of the literature review which will primarily deal with building a consistent argument in support of the initial research query. This will start by giving a detailed background of the theoretical framework. Moreover aspects of the damage procured to Gazan infrastructure and civilians will be discussed and tied to Israeli perceptions of threat during the military intervention, with existing empirical and statistical research. Moreover the next chapter will be the actual discursive analysis and discussion of a number of texts sourced from the website of the Israeli Ministry of Foreign Relations, after which the last section shall qualify the nature of the results obtained from the analysis. Key words: Proportionality, chosen trauma, identity, Israel, Hamas, Gaza.
Complement activation in children with Streptococcus pneumoniae associated hemolytic uremic syndrome
Creators: name: Holle, Johannes
name: Habbig, Sandra
name: Gratopp, Alexander
name: Mauritsch, Anna
name: Müller, Dominik
name: Thumfart, Julia
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Hemolytic uremic syndrome
subject: Complement
subject: Eculizumab
subject: Children
subject: Streptococcus pneumonia
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Hemolytic uremic syndrome caused by invasive pneumococcal disease (P-HUS) is rare in children and adolescents, but accompanied by high mortality in the acute phase and complicated by long-term renal sequelae. Abnormalities in the alternative complement pathway may additionally be contributing to the course of the disease but also to putative treatment options. Methods: Retrospective study to assess clinical course and laboratory data of the acute phase and outcome of children with P-HUS. Results: We report on seven children (median age 12 months, range 3-28 months) diagnosed with P-HUS. Primary organ manifestation was meningitis in four and pneumonia in three patients. All patients required dialysis which could be discontinued in five of them after a median of 25 days. In two patients, broad functional and genetic complement analysis was performed and revealed alternative pathway activation and risk haplotypes in both. Three patients were treated with the complement C5 inhibitor eculizumab. During a median follow-up time of 11.3 years, one patient died due to infectious complications after transplantation. Two patients showed no signs of renal sequelae. Conclusions: Although pathophysiology in P-HUS remains as yet incompletely understood, disordered complement regulation seems to provide a clue to additional insights for pathology, diagnosis, and even targeted treatment.
Psychosocial Impact of COVID-19 Pandemic in Elderly Psychiatric Patients: a Longitudinal Study
Creators: name: Seethaler, Magdalena
name: Just, Sandra
name: Stötzner, Philip
name: Bermpohl, Felix
name: Brandl, Eva Janina
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: COVID-19
subject: Elderly
subject: Geriatric psychiatry
subject: Mental health
subject: Psychosocial burden
subject: Depression
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The study was designed to investigate the impact of the Coronavirus Disease 2019 (COVID-19) pandemic on mental health and perceived psychosocial support for elderly psychiatric patients in a longitudinal design. n = 32 patients with affective or anxiety disorders aged >= 60 years were included. Telephone interviews were conducted in April/May 2020 (T1) and August 2020 (T2). The psychosocial impact (PSI) of the pandemic and psychopathology were measured. Changes between T1 and T2 were examined. Patients' psychosocial support system six months before the pandemic and at T1/T2 was assessed. We found a significant positive correlation between general PSI and depression as well as severity of illness. General PSI differed significantly depending on social contact. Neither general PSI nor psychopathology changed significantly between T1 and T2. At T1, patients' psychosocial support systems were reduced as compared to six months before. Patients reported an increase in psychosocial support between T1 and T2 and high demand for additional support (sports, arts/occupational therapy, physiotherapy, psychotherapy). Elderly psychiatric patients show a negative PSI of the pandemic. They are likely to suffer from an impaired psychosocial situation, emphasizing the importance of developing concepts for sufficient psychosocial support during a pandemic.
PuraStat in gastrointestinal bleeding: results of a prospective multicentre observational pilot study
Creators: name: Branchi, Federica
name: Klingenberg-Noftz, Rolf
name: Friedrich, Kristina
name: Bürgel, Nataly
name: Daum, Severin
name: Buchkremer, Juliane
name: Sonnenberg, Elena
name: Schumann, Michael
name: Treese, Christoph
name: Tröger, Hanno
name: Lissner, Donata
name: Epple, Hans-Jörg
name: Siegmund, Britta
name: Stroux, Andrea
name: Adler, Andreas
name: Veltzke-Schlieker, Winfried
name: Autenrieth, Daniel
name: Leonhardt, Silke
name: Fischer, Andreas
name: Jürgensen, Christian
name: Pape, Ulrich-Frank
name: Wiedenmann, Bertram
name: Möschler, Oliver
name: Schreiner, Maximilian
name: Strowski, Mathias Z.
name: Hempel, Volkmar
name: Huber, Yvonne
name: Neumann, Helmut
name: Bojarski, Christian
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: PuraStat
subject: Haemostasis
subject: Gastrointestinal bleeding
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: A recently developed haemostatic peptide gel for endoscopic application has been introduced to improve the management of gastrointestinal bleeding. The aim of this pilot study was to evaluate the feasibility, safety, efficacy and indication profiles of PuraStat in a clinical setting. Methods: In this prospective observational multicentre pilot study, patients with acute non-variceal gastrointestinal bleeding (upper and lower) were included. Primary and secondary application of PuraStat was evaluated. Haemoglobin, prothrombin time, platelets and transfusion behaviour were documented before and after haemostasis. The efficacy of PuraStat was assessed during the procedure, at 3 days and 1 week after application. Results: 111 patients with acute gastrointestinal bleeding were recruited into the study. 70 percent (78/111) of the patients had upper gastrointestinal bleeding and 30% (33/111) had lower gastrointestinal bleeding. After primary application of PuraStat, initial haemostatic success was achieved in 94% of patients (74/79, 95% CI 88-99%), and in 75% of the patients when used as a secondary haemostatic product, following failure of established techniques (24/32, 95% CI 59-91%). The therapeutic success rates (absence of rebleeding) after 3 and 7 days were 91% and 87% after primary use, and 87% and 81% in all study patients. Overall rebleeding rate at 30 day follow-up was 16% (18/111). In the 5 patients who finally required surgery (4.5%), PuraStat allowed temporary haemostasis and stabilisation. Conclusions: PuraStat expanded the therapeutic toolbox available for an effective treatment of gastrointestinal bleeding sources. It could be safely applied and administered without complications as a primary or secondary therapy. PuraStat may additionally serve as a bridge to surgery in order to achieve temporary haemostasis in case of refractory severe bleeding, possibly playing a role in preventing immediate emergency surgery.
title: Targeting Rab6/Km23-1 Mediated Compartmentalized Trafficking as a Novel Therapeutic Approach to Alzheimer's Disease
Creators: name: Zhang, Ruth
Publisher: name: George Mason University
Year: 2021
Subjects: subject: Alzheimer’s Disease
subject: Pull-Down Assay
subject: Protein Painting
subject: Gel Electrophoresis
subject: Rab6
subject: Km23-1 (DYNLRB1)

description: This thesis has been embargoed for 10 years. It will not be available until August 2030 at the earliest.
description: Alzheimer’s Disease (AD) is a prevalent neurodegenerative disease in not only the US but worldwide. Approximately, as of 2020, around 5.8 million Americans, ages 65 and over may be living with AD. AD is a disease where the patient slowly has their mental process deteriorate, causing the patient to not be able to perform everyday tasks, causing an amnesia-like memory retention, and eventually, in severe cases, ending in an vegetative state, and requiring 24/7 care. AD can either be passed down generation to generation or cases can be sporadic, which is more common. Through the years, researchers have focused on an array of hypotheses on the disease pathogenesis and the Amyloid Hypothesis is the most studied. At the molecular level, amyloid beta (Aβ) plaques derive from the breakdown of a protein names amyloid precursor protein (APP). Amyloid fragments clump together and form plaques that accumulate between neurons and destroy cell functions. Many therapies have been targeted to the downstream effects of amyloid beta formation. Unfortunately, these therapies had little success in reducing the cell brain destruction caused by AD so a novel and fresh approach to AD therapy is greatly needed. In this study, we focus on two proteins, Rab6 and Km23-1 that may play an important role in the formation of amyloid plaques by mediating trafficking of APP in the neuronal cell. Our hypothesis is that the interaction between Km23-1 and Rab6 contributes to the cleavage of APP through over reactive Golgi trafficking, which leads to Aβ plaque formation. If this hypothesis is confirmed, targeting the Rab6/Km23-1 protein complex becomes a potentially attractive pharmacological strategy for AD. The work presented in this thesis contributes two major achievements: for the first time, we demonstrated that Rab6 and Km23-1 form a protein complex in vitro, and 2) we developed an experimental pipeline to use the mass spectrometry based protein painting technology to identify functionally relevant hot spots of interaction. Information derived from protein painting can be used to design specific and potent inhibitors to disrupt the Rab6/Km23-1 protein complex.
title: Correspondence: Margaret Bowersett and C. Harrison Mann, Jr., September 14, 1961-September 20, 1961
Creators: name: Bowersett, Margaret
name: Mann, Charles Harrison, Jr., 1908-1977
Publisher: name: George Mason University
Year: 2006
Subjects: subject: Voting
subject: Fraud

description: Letter A: handwritten signed, 6" x 9" (15.2cm x 22.9cm); Letter B: typescript unsigned, (8.5" x 11" (21.6cm x 27.9cm)
description: Correspondence between Margaret Bowersett and C. Harrison Mann, Jr. regarding voting machines. Bowersett does not agree with them and Mann says they are a good deterrent to voter fraud. C. Harrison Mann, Jr. Collection 3.10
Guangdong Qing dai dang an lu [volume 06]
廣東清代檔案錄 [第六冊]
Creators: name: (:Null)
Publisher: name: The University of British Columbia
Year: 2016

description: A handwritten copy of archives about Guangdong in Qing dynasty.
Title from label, on double leaves, East Asian binding. Sealed by Yao Junshi.
Edition: [Chao ben]
Guangdong Qing dai dang an lu [volume 05]
廣東清代檔案錄 [第五冊]
Creators: name: (:Null)
Publisher: name: The University of British Columbia
Year: 2016

description: A handwritten copy of archives about Guangdong in Qing dynasty.
Title from label, on double leaves, East Asian binding. Sealed by Yao Junshi.
Edition: [Chao ben]
Supplementary document for Enhancement of second-order optical nonlinearities and nanoscale periodic domain patterning in ferroelectric boron-substituted aluminum nitride thin films - 6311034.pdf
Creators: name: Suceava, Albert
name: Hayden, John
name: Kelley, Kyle
name: Xiong, Yihuang
name: Fazlioglu-Yalcin, Benazir
name: Dabo, Ismaila
name: Trolier-McKinstry, Susan
name: Maria, Jon-Paul
name: Gopalan, Venkatraman
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental Material document referred to as "Supplement 1" in the body of the manuscript. This carries an additional figure and details on modelling parameters used by not expanded upon in the main body of the manuscript.
A symptom-based approach in predicting ECT outcome in depressed patients employing MADRS single items
Creators: name: Carstens, Luisa
name: Hartling, Corinna
name: Stippl, Anna
name: Domke, Ann-Kathrin
name: Herrera-Mendelez, Ana Lucia
name: Aust, Sabine
name: Gärtner, Matti
name: Bajbouj, Malek
name: Grimm, Simone
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Electroconvulsive therapy (ECT)
subject: Montgomery-Asberg Depression Rating Scale (MADRS)
subject: Depression
subject: Response prediction
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Establishing symptom-based predictors of electroconvulsive therapy (ECT) outcome seems promising, however, findings concerning the predictive value of distinct depressive symptoms or subtypes are limited; previous factor-analytic approaches based on the Montgomery-Asberg Depression Rating Scale (MADRS) remained inconclusive, as proposed factors varied across samples. In this naturalistic study, we refrained from these previous factor-analytic approaches and examined the predictive value of MADRS single items and their change during the course of ECT concerning ECT outcome. We used logistic and linear regression models to analyze MADRS data routinely assessed at three time points in 96 depressed psychiatric inpatients over the course of ECT. Mean age was 53 years (SD 14.79), gender ratio was 58:38 (F:M), baseline MADRS score was M = 30.20 (SD 5.42). MADRS single items were strong predictors of ECT response, remission and overall symptom reduction, especially items 1 (apparent sadness), 2 (reported sadness) and 8 (inability to feel), assessing affective symptoms. Strongest effects were found for regression models including item 2 (reported sadness) with up to 80% correct prediction of ECT outcome. ROC analyses were performed to estimate the optimal cut-point for treatment response. MADRS single items during the course of ECT might pose simple, reliable, time- and cost-effective predictors of ECT outcome. More severe affective symptoms of depression at baseline and a stronger reduction of these affective symptoms during the course of ECT seem to be positively associated with ECT outcome. Precise cut-off values for clinical use were proposed. Generally, these findings underline the benefits of a symptom-based approach in depression research and treatment in addition to depression sum-scores and generalized diagnoses.
Women bear a burden: gender differences in health of older migrants from Turkey
Creators: name: Krobisch, Verena
name: Gebert, Pimrapat
name: Gül, Kübra
name: Schenk, Liane
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Ethnicity
subject: Migration
subject: Sex
subject: Elders
subject: Self-reported health
subject: Mixed methods
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Studies show that older migrants have poorer health than native populations in Western Europe. To date, little systematic research has explored the differences between men and women within older populations with migration backgrounds. This article examines gender-specific aspects and mediating mechanisms of self-reported health among older migrants from Turkey. Using a mixed method approach, data and results from a quantitative survey and a qualitative study conducted in Berlin, Germany, are analysed and integrated at the interpretive level. Standardised face-to-face interviews were carried out with the help of a network approach with 194 older migrants from Turkey (93 women, 101 men, mean age: 68). Potential mediators showing significant gender differences are included in a parallel multiple mediation analysis. The documentary method is used to analyse 11 semi-structured narrative interviews with first-generation labour migrants from Turkey. Women reported significantly worse subjective health than men (c = 0.443, bCI [0.165-0.736]), conveyed through greater functional limitations (ab = 0.183, bCI [0.056-0.321]) and emotional loneliness (ab = 0.057, bCI [0.008-0.128]). Respondents to the qualitative study perceived that women age earlier and have poorer health due to the burden of performing a greater variety of social roles. Higher levels of emotional loneliness among women could be caused by their experiences of negatively assessed partnerships. Our results show that as a group, older female migrants have an elevated health vulnerability. A broader scientific foundation regarding gender differences in the health of older migrants and their causes is needed to promote gender-sensitive prevention and care for this group.
Structures of active melanocortin-4 receptor–Gs-protein complexes with NDP-α-MSH and setmelanotide
Creators: name: Heyder, Nicolas A.
name: Kleinau, Gunnar
name: Speck, David
name: Schmidt, Andrea
name: Paisdzior, Sarah
name: Szczepek, Michal
name: Bauer, Brian
name: Koch, Anja
name: Gallandi, Monique
name: Kwiatkowski, Dennis
name: Bürger, Jörg
name: Mielke, Thorsten
name: Beck-Sickinger, Annette G.
name: Hildebrand, Peter W.
name: Spahn, Christian M. T.
name: Hilger, Daniel
name: Schacherl, Magdalena
name: Biebermann, Heike
name: Hilal, Tarek
name: Kühnen, Peter
name: Kobilka, Brian K.
name: Scheerer, Patrick
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: melanocortin-4 receptor (MC4R)
subject: NDP-α-MSH
subject: setmelanotide
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The melanocortin-4 receptor (MC4R), a hypothalamic master regulator of energy homeostasis and appetite, is a class A G-protein-coupled receptor and a prime target for the pharmacological treatment of obesity. Here, we present cryo-electron microscopy structures of MC4R-Gs-protein complexes with two drugs recently approved by the FDA, the peptide agonists NDP-alpha-MSH and setmelanotide, with 2.9 angstrom and 2.6 angstrom resolution. Together with signaling data from structure-derived MC4R mutants, the complex structures reveal the agonist-induced origin of transmembrane helix (TM) 6-regulated receptor activation. The ligand-binding modes of NDP-alpha-MSH, a high-affinity linear variant of the endogenous agonist alpha-MSH, and setmelanotide, a cyclic anti-obesity drug with biased signaling toward Gq/11, underline the key role of TM3 in ligand-specific interactions and of calcium ion as a ligand-adaptable cofactor. The agonist-specific TM3 interplay subsequently impacts receptor-Gs-protein interfaces at intracellular loop 2, which also regulates the G-protein coupling profile of this promiscuous receptor. Finally, our structures reveal mechanistic details of MC4R activation/inhibition, and provide important insights into the regulation of the receptor signaling profile which will facilitate the development of tailored anti-obesity drugs.
Screening zur frühen Identifizierung des psychosozialen Unterstützungsbedarfs bei Kindern psychisch erkrankter Eltern
Creators: name: Holl-Etten, Anna Katharina
name: Bentz, Lea
name: Calvano, Claudia
name: Winter, Sibylle M.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Child maltreatment
subject: Child neglect
subject: Family stress
subject: Resources
subject: Risk factors
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Children of mentally ill parents have an increased risk for mental disorders themselves, which is increased once again by the experience of abuse and neglect. Objective: The aim of this study is to present the development and preliminary piloting of a specific screening procedure that enables an early identification of a possible need for support in children with mentally ill parents. Material and methods: For children of mentally ill parents, two screening procedures were developed. In the parent questionnaire of the "children screening" mental abnormalities of the children and adolescents (6-18 years old) as well as resources are collated in an abbreviated form (mental abnormalities: 26 items, available resources: 4 items). In the "family screening" familial risk and stress factors (8 items) are also enquired about in a self-report of the parents as well as indications for abuse and neglect in the family (9 items). Results: Both screening procedures are easy to evaluate with the help of a traffic light system. The responsible psychiatrist receives a preliminary estimation and definite indications on the current need for psychosocial treatment and support of the whole family and particularly the children. Subsequently, they can initiate further steps for the integrated care of the family. Conclusion: The children and family screening procedures are economical in time and easily understandable screening procedures for identification of the need for treatment and support of the family. Subsequently, after the final validation it is planned to systematically implement the screening procedures in the psychiatric care of mentally ill parents. In this way the far-reaching negative consequences for these children can be prevented.
Dexmedetomidine Restores Autophagic Flux, Modulates Associated microRNAs and the Cholinergic Anti-inflammatory Pathway upon LPS-Treatment in Rats
Creators: name: Kho, Widuri
name: Haefen, Clarissa Von
name: Paeschke, Nadine
name: Nasser, Fatme
name: Endesfelder, Stefanie
name: Sifringer, Marco
name: González-López, Adrián
name: Lanzke, Nadine
name: Spies, Claudia D.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Dexmedetomidine
subject: Brain
subject: Spleen
subject: Autophagy
subject: microRNA
subject: Cholinergic anti-inflammatory pathway
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Infections and perioperative stress can lead to neuroinflammation, which in turn is linked to cognitive impairments such as postoperative delirium or postoperative cognitive dysfunctions. The alpha 2-adrenoceptor agonist dexmedetomidine (DEX) prevents cognitive impairments and has organo-protective and anti-inflammatory properties. Macroautophagy (autophagy) regulates many biological processes, but its role in DEX-mediated anti-inflammation and the underlying mechanism of DEX remains largely unclear. We were interested how a pretreatment with DEX protects against lipopolysaccharide (LPS)-induced inflammation in adult male Wistar rats. We used Western blot and activity assays to study how DEX modulated autophagy- and apoptosis-associated proteins as well as molecules of the cholinergic anti-inflammatory pathway, and qPCR to analyse the expression of autophagy and inflammation-associated microRNAs (miRNA) in the spleen, cortex and hippocampus at different time points (6 h, 24 h, 7 d). We showed that a DEX pretreatment prevents LPS-induced impairments in autophagic flux and attenuates the LPS-induced increase in the apoptosis-associated protein cleaved poly(ADP-ribose)-polymerase (PARP) in the spleen. Both, DEX and LPS altered miRNA expression and molecules of the cholinergic anti-inflammatory pathway in the spleen and brain. While only a certain set of miRNAs was up- and/or downregulated by LPS in each tissue, which was prevented or attenuated by a DEX pretreatment in the spleen and hippocampus, all miRNAs were up- and/or downregulated by DEX itself - independent of whether or not they were altered by LPS. Our results indicate that the organo-protective effect of DEX may be mediated by autophagy, possibly by acting on associated miRNAs, and the cholinergic anti-inflammatory pathway.
Resident Assistant Workplace Motivation: A Mid-Atlantic Regional Study
Creators: name: Boone, Katherine Bennett
Publisher: name: Maryland Shared Open Access Repository
Year: 2016
Subjects: motivation
RA
RA job
RA role
resident assistant
resident assistant motivation

description: Minimal research has been conducted relative to the sources of work motivation for resident assistants (RAs) over the last decade. As more challenges and responsibilities are added to the expectations of the RA position, determining what current factors motivate students to apply for the RA position is essential. By identifying and better understanding the motivational factors of students who accept the RA role, housing professionals may focus their energies more appropriately in order to staff the position with highly qualified individuals. The literature review traces the evolution of the RA position and cites relevant research on motivation. The study included 231 respondents from 46 different institutions in the Mid-Atlantic region. The research found that helping behaviors was the most prominent factor for seeking the RA position. The desire to meet financial obligations was also a significant consideration. RA cohesiveness also was a factor of prominence. There were no significant differences in motivational factors when looking at demographic characteristics (gender, race/ethnicity) or work characteristics (type of residential community, semesters in the RA position, class standing of population RA was serving, number of students the RA served on floor/wing, and type of institution) In addition, there were no work or demographic characteristics that could predict high levels of motivation for current RAs. This finding can allow housing professionals to focus more clearly on one recruitment strategy.
Differentiation of Cerebral Neoplasms with Vessel Size Imaging (VSI)
Creators: name: Foda, Asmaa
name: Kellner, Elias
name: Gunawardana, Asanka
name: Gao, Xiang
name: Janz, Martin
name: Kufner, Anna
name: Khalil, Ahmed A.
name: Geran, Rohat
name: Mekle, Ralf
name: Fiebach, Jochen B.
name: Galinovic, Ivana
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Magnetic resonance imaging
subject: Brain imaging
subject: Brain tumors
subject: Microvasculature
subject: Differential diagnosis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: Cerebral neoplasms of various histological origins may show comparable appearances on conventional Magnetic Resonance Imaging (MRI). Vessel size imaging (VSI) is an MRI technique that enables noninvasive assessment of microvasculature by providing quantitative estimates of microvessel size and density. In this study, we evaluated the potential of VSI to differentiate between brain tumor types based on their microvascular morphology. Methods: Using a clinical 3T MRI scanner, VSI was performed on 25 patients with cerebral neoplasms, 10 with glioblastoma multiforme (GBM), 8 with primary CNS lymphoma (PCNSL) and 7 with cerebral lung cancer metastasis (MLC). Following the postprocessing of VSI maps, mean vessel diameter (vessel size index, vsi) and microvessel density (Q) were compared across tumors, peritumoral areas, and healthy tissues. Results: The MLC tumors have larger and less dense microvasculature compared to PCNSLs in terms of vsi and Q (p = 0.0004 and p < 0.0001, respectively). GBM tumors have higher yet non-significantly different vsi values than PCNSLs (p = 0.065) and non-significant differences in Q. No statistically significant differences in vsi or Q were present between GBMs and MLCs. GBM tumor volume was positively correlated with vsi (r = 0.502, p = 0.0017) and negatively correlated with Q (r = -0.531, p = 0.0007). Conclusion: Conventional MRI parameters are helpful in differentiating between PCNSLs, GBMs, and MLCs. Additionally incorporating VSI parameters into the diagnostic protocol could help in further differentiating between PCNSLs and metastases and potentially between PCNSLs and GBMs. Future studies in larger patient cohorts are required to establish diagnostic cut-off values for VSI.
Guangdong Qing dai dang an lu [volume 09]
廣東清代檔案錄 [第九冊]
Creators: name: (:Null)
Publisher: name: The University of British Columbia
Year: 2016

description: A handwritten copy of archives about Guangdong in Qing dynasty.
Title from label, on double leaves, East Asian binding. Sealed by Yao Junshi.
Edition: [Chao ben]
Supplementary document for All-day uninterrupted thermoelectric generator by simultaneous harvesting of solar heating and radiative cooling - 6312403.pdf
Creators: name: Liu, Jing
name: Li, Degui
name: Ma, Wenzhuang
name: Chen, Yushan
name: Dou, Chao
name: meng, dan
name: He, Qiyao
name: Li, Xiangyu
name: deng, xuchu
name: Cai, Haoyuan
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary materials
MPEC 2024-P105 : 2022 BF2
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Zhu Zixiang xian sheng za gao
朱子襄先生雜藁
Creators: name: Zhu, Ciqi, 1807-1881
name: 朱次琦, 1807-1881
Publisher: name: The University of British Columbia
Year: 2016

description: A handwritten copy of Zhu Ciqi's essays. Title form cover, on double leaves, East Asian binding. Sealed by Yao Junshi.
Edition: [Chao ben]
A tailored approach in lymph node-positive perihilar cholangiocarcinoma
Creators: name: Benzing, Christian
name: Krenzien, Felix
name: Mieg, Alexa
name: Wolfsberger, Annika
name: Andreou, Andreas
name: Nevermann, Nora
name: Pelzer, Uwe
name: Fehrenbach, Uli
name: Haiden, Lena Marie
name: Öllinger, Robert
name: Schöning, Wenzel
name: Schmelzle, Moritz
name: Pratschke, Johann
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Lymph node positive perihilar cholangiocarcinoma
subject: Major hepatectomy
subject: Long-term survival
subject: Postoperative complications
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose Extended right hepatectomy is associated with wide surgical margins in PHC and often favored for oncological considerations. However, it remains uncertain whether established surgical principles also apply to the subgroup of node-positive patients. The aim of the present study was to define a tailored surgical approach for patients with perihilar cholangiocarcinoma (PHC) and lymph node metastases. Methods We reviewed the course of all consecutive patients undergoing major hepatectomy for PHC between 2005 and 2015 at the Department of Surgery, Charite - Universitatsmedizin Berlin. Results Two hundred and thirty-one patients underwent major hepatectomy for PHC with 1-, 3-, and 5-year overall (OS) and disease-free survival (DFS) rates of 72%, 48%, and 36%, and 60%, 22%, and 12%, respectively. In lymph node-positive patients (n = 109, 47%), extended left hepatectomy was associated with improved OS and DFS, respectively, when compared to extended right hepatectomy (p = 0.008 and p = 0.003). Interestingly, OS and DFS did not differ between R0 and R1 resections in those patients (both p = ns). Patients undergoing extended left hepatectomy were more likely to receive adjuvant chemotherapy (p = 0.022). This is of note as adjuvant chemotherapy, besides grading (p = 0.041), was the only independent prognostic factor in node-positive patients (p=0.002). Conclusion Patients with node-positive PHC might benefit from less aggressive approaches being associated with lower morbidity and a higher chance for adjuvant chemotherapy. Lymph node sampling might help to guide patients to the appropriate surgical approach according to their lymph node status.
The impact of surgical site infection—a cost analysis
Creators: name: Strobel, Rahel M.
name: Leonhardt, Marja
name: Förster, Frank
name: Neumann, Konrad
name: Lobbes, Leonard A.
name: Seifarth, Claudia
name: Lee, Lucas D.
name: Schineis, Christian H. W.
name: Kamphues, Carsten
name: Weixler, Benjamin
name: Kreis, Martin E.
name: Lauscher, Johannes C.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Surgical site infection
subject: Cost analysis
subject: Visceral surgery
subject: Laparotomy
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: Surgical site infection (SSI) occurs in up to 25% of patients after elective laparotomy. We aimed to determine the effect of SSI on healthcare costs and patients' quality of life. Methods: In this post hoc analysis based on the RECIPE trial, we studied a 30-day postoperative outcome of SSI in a single-center, prospective randomized controlled trial comparing subcutaneous wound irrigation with 0.04% polyhexanide to 0.9% saline after elective laparotomy. Total medical costs were analyzed accurately per patient with the tool of our corporate controlling team which is based on diagnosis-related groups in Germany. Results: Between November 2015 and May 2018, 456 patients were recruited. The overall rate of SSI was 28.2%. Overall costs of inpatient treatment were higher in the group with SSI: median 16.685 euro; 19.703 USD (IQR 21.638 euro; 25.552 USD) vs. median 11.235 euro; 13.276 USD (IQR 11.564 euro; 13.656 USD); p < 0.001. There was a difference in surgery costs (median 6.664 euro; 7.870 USD with SSI vs. median 5.040 euro; 5.952 USD without SSI; p = 0.001) and costs on the surgical ward (median 8.404 euro; 9.924 USD with SSI vs. median 4.690 euro; 5.538 USD without SSI; p < 0.001). Patients with SSI were less satisfied with the cosmetic result (4.3% vs. 16.2%; p < 0.001). Overall costs for patients who were irrigated with saline were median 12.056 euro; 14.237 USD vs. median 12.793 euro; 15.107 USD in the polyhexanide group (p = 0.52). Conclusion: SSI after elective laparotomy increased hospital costs substantially. This is an additional reason why the prevention of SSI is important. Overall costs for intraoperative wound irrigation with saline were comparable with polyhexanide.
Does stereoscopic imaging improve the memorization of medical imaging by neurosurgeons? Experience of a single institution
Creators: name: Schlinkmann, Nicolas
name: Khakhar, Rutvik
name: Picht, Thomas
name: Piper, Sophie K.
name: Fekonja, Lucius S.
name: Vajkoczy, Peter
name: Acker, Gueliz
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: 3D
subject: Stereoscopic
subject: Memorization
subject: Imaging
subject: Neurosurgery
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Stereoscopic imaging has increasingly been used in anatomical teaching and neurosurgery. The aim of our study was to analyze the potential utility of stereoscopic imaging as a tool for memorizing neurosurgical patient cases compared to conventional monoscopic visualization. A total of 16 residents and 6 consultants from the Department of Neurosurgery at Charite - Universitatsmedizin Berlin were recruited for the study. They were divided into two equally experienced groups. A comparative analysis of both imaging modalities was conducted in which four different cases were assessed by the participants. Following the image assessment, two questionnaires, one analyzing the subjective judgment using the 5-point Likert Scale and the other assessing the memorization and anatomical accuracy, were completed by all participants. Both groups had the same median year of experience (5) and stereoacuity (<= 75 s of arc). The analysis of the first questionnaire demonstrated significant subjective superiority of the monoscopic imaging in evaluation of the pathology (median: monoscopic: 4; stereoscopic: 3; p =0.020) and in handling of the system (median: monoscopic: 5; stereoscopic: 2; p < 0.001). The second questionnaire showed that the anatomical characterization of the pathologies was comparable between both visualization methods. Most participants rated the stereoscopic visualization as worse compared to the monoscopic visualization, probably due to a lack of familiarity with the newer technique. Stereoscopic imaging, however, was not objectively inferior to traditional monoscopic imaging for anatomical comprehension. Further methodological developments and incorporation in routine clinical workflows will most likely enhance the usability and acceptance of stereoscopic visualization.