Additional file 1 of Oxygen-enhanced MRI assessment of tumour hypoxia in head and neck cancer is feasible and well tolerated in the clinical setting
Creators: name: McCabe, Alastair
name: Martin, Stewart
name: Rowe, Selene
name: Shah, Jagrit
name: Morgan, Paul S.
name: Borys, Damian
name: Panek, Rafal
Publisher: name: figshare
Year: 2024
Subjects: subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Cancer

description: Additional file 1: Appendix 1. Tumour characteristics and OE-MRI derived parameters for all identified primary tumours and malignant nodal masses. Fig. S1. A member of the research team modelling the participant setup. The posterior component of the head coil was used together with an ultraflex large 18-channel coil positioned over the neck region allowing ready placement of the non-rebreather oxygen mask. The non-rebreather bag was positioned on top of the ultraflex coil. Study participants wore ear plugs and ear defenders and did not wear a surgical face mask during the scan. Fig. S2. T1 values for 12 tubes in a Eurospin TO5 phantom measured using the study dynamic vibe sequence. T1 values quoted are mean values over all 40 acquisitions. Coefficient of variations quoted for each tube have a median value of 0.2%. Fig. S3. Example OE-MRI parametrical maps in a patient with a suspected malignant nodal mass (patient no: 16 Lymph Node no: 2). Low estimated hypoxic fraction (11.6%) is shown on a T1 weighted vibe image with overlaid parametric ΔT1 map of the malignant mass (a, d, axial and coronal plane respectively) and overlaid statistical map of ΔT1 times (b, e). Blue colour indicates statistically significant decrease in T1 times, white indicating no statistically significant change and red indicating statistically significant increasing T1 times. c Time series of T1 times averaged over the entire malignant node VOI and over those voxels with significantly decreasing T1 times only. f Histogram of ΔT1 times for the entire malignant nodal VOI. OE-MRI Oxygen-enhanced magnetic resonance imaging, VIBE Volumetric interpolated breath-hold examination, VOI Volume of interest. Fig. S4. Example OE-MRI parametrical maps in a patient with a suspected malignant nodal mass (patient no: 15 Lymph Node no: 7). High estimated hypoxic fraction (72.0%) is shown on a T1 weighted vibe image with overlaid parametric ΔT1 map of the malignant mass (a, d, axial and coronal plane respectively) and overlaid statistical map of ΔT1 times (b, e). Blue colour indicates statistically significant decrease in T1 times, white indicating no statistically significant change and red indicating statistically significant increasing T1 times. c Time series of T1 times averaged over the entire malignant node VOI and over those voxels with significantly decreasing T1 times only. f Histogram of ΔT1 times for the entire malignant nodal VOI. OE-MRI Oxygen-enhanced magnetic resonance imaging, VIBE Volumetric interpolated breath-hold examination, VOI Volume of interest. Supplementary Table S1. Summed scores from all patient participants for each of the 15 domains assessed in the MRI specific anxiety questionnaire.