cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 4: of GBS-SNP-CROP: a reference-optional pipeline for SNP discovery and plant germplasm characterization using variable length, paired-end genotyping-by-sequencing data
Creators: name: Melo, Arthur
name: Bartaula, Radhika
name: Hale, Iago
Publisher: name: Figshare
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: List of the 48 A. arguta genotypes used for GBS-SNP-CROP development and analysis. AdditionalFile4.pdf presents the names of the genotypes from the USDA National Clonal Germplasm Repository used in this study, along with their barcodes and the number of parsed GBS reads obtained for each. (PDF 50 kb)
Termitomorpha Wasmann 1894
Creators: name: Caron, Edilson
name: Bortoluzzi, Sidnei
name: Rosa, Cassiano S.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Staphylinidae
Termitomorpha

description: Genus Termitomorpha Wasmann
Wasmann 1894: 210 (description, included species: T. meinerti Wasmann, 1894); Kistner & Jacobson 1976: 8 (redescription of the genus); Jacobson et al. 1986: 76 (the most recent complete bibliographic and synonymic list, including five species); Kistner 2006: 618 (redescription of T. huachii Seevers, 1946 and meinerti).
Type species: T. meinerti Wasmann, 1894 (designation by monotypy).
description: Published as part of Caron, Edilson, Bortoluzzi, Sidnei & Rosa, Cassiano S., 2018, Two new species of obligatory termitophilous rove beetles from Brazil (Coleoptera: Staphylinidae: Termitomorpha Wasmann), pp. 566-578 in Zootaxa 4413 (3) on page 567, DOI: 10.11646/zootaxa.4413.3.10, http://zenodo.org/record/1227839
Universal, not Global, science: why Open Access is crucial to the good health of scientific communication
Creators: name: Guédon, Jean-Claude
Publisher: name: Zenodo
Year: 2015

description: Since the WWII, the landscape of scientific communication has quietly, yet deeply, changed. The advent of the Science Citation Index in the ’70’s, the growth of commercial publishers, and, finally, the fundamental affordances of digitization and the Internet have converged to create an oligopolistic structure to scientific communication. Scientific communication has thus been globalized in ways that are not all that different from economic globalization. Open Access may be a way to correct this situation, but only if some further conditions are also respected and implemented. The presentation will explore some of these conditions to reach the goal of universality for science.
Grundlagen der Robotic Process Automation. Stand der Forschung und Diskussion in der Praxis
Creators: name: Habegger, Anja
name: Arnautovic, Hanka
name: Haller, Stephan
Publisher: name: Springer Fachmedien Wiesbaden
Year: 2021

description: Große Teile der Arbeitswelt stecken aktuell in der Transformation zur Industrie 4.0. Ziel dieser vierten industriellen Revolution ist eine wirtschaftliche Produktion durch dezentral gesteuerte, autonome Prozesse, unterstützt durch Digitalisierung und Automatisierung sowie durch die Vernetzung von Maschinen, Robotern, Werkstücken und Mitarbeitenden. Die Auswirkungen dieser Entwicklung auf die Arbeitswelt werden kontrovers diskutiert; Szenarien von der Vernichtung von Millionen von Arbeitsplätzen in den nächsten fünf Jahren bis hin zur Schaffung praktisch ebenso vieler neuer Beschäftigungsmöglichkeiten mit veränderten Qualifikationsanforderungen über alle Branchen hinweg stehen in Literatur und Praxis einander gegenüber. Robotic Process Automation stellt in dieser Entwicklung einen ersten Schritt auf dem Weg zu einer intelligenten Prozessautomation dar und bietet Unternehmen den Einstieg in die Digitalisierung und Automatisierung von Prozessen sowie in die Kollaboration von Menschen und Softwarerobotern.
Technik, Ökobilanz - und Romantik
Creators: name: Ganne-Chédeville, Christelle
name: Pichelin, Frédéric
name: Geiser, Martin
name: Staub, Peter
Publisher: name: Lars Müller Publishers
Year: 2022

description: Wie nachhatlig ist der gesamte Lebenszyklus des Holzes vom Baum im Wald bis zum fertigen Produkt und letztlich dessen Entsorgung? Das Gespräch unter Expertinnen und Experten der Berner Fachhochschule entlang der Wertschöpfungskette zeigt deutlich, dass die Antwort a priori nicht leicht fällt. Viele Faktoren müssen in die Rechnung mit einbezogen werden. für die Forschung ist es eine kontinuierliche Arbeit zwischen Rückschlägen und Innovation.
Förderung musikalischer Begabung im Schulalter
Creators: name: Von Steiger, Adrian
Year: 2005

description: Programm zur Talentförderung in Köniz/BE: Der «Schwerpunkt Musik auf der Sekundarstufe I» füllt eine Lücke im Lehrangebot für Siebt- bis Neuntklässler, die sich fundiert und breit mit Musik auseinander setzen wollen. Geführt wird der SpM durch die Musikschule im Rahmen ihres Leistungsauftrags. Dank der Möglichkeit, in andern Fächern Stunden zu entlasten, sind die Teilnehmenden schulisch nicht übermässig belastet.
Reliability of the virtual elevation method to evaluate rolling resistance of different mountain bike cross-country tyres
Creators: name: Maier, Thomas
name: Müller, Beat
name: Schmid, Lucas
name: Steiner, Thomas
name: Wehrlin, Jon
Publisher: name: Taylor & Francis
Year: 2018
Subjects: Off-road cycling aerodynamic drag mathematical model Leistungssport Ausdauer

description: Although a low rolling resistance is advantageous in mountain bike cross-country racing, no studies have used the virtual elevation method to compare tyres from different manufacturers as used in international competitions so far. The aims of this study were to assess the reliability of this method, to compare the off-road rolling resistance between tyres and to calculate the influence on off-road speed. Nine 29-in. mountain bike cross-country tyres were tested on a course representing typical ground surface conditions 5 or 6 times. The coefficient of rolling resistance was estimated with the virtual elevation method by 3 investigators and corresponding off-road speeds were calculated. The virtual elevation method was highly reliable (typical error = 0.0006, 2.8%; limits of agreement <0.0005, r ≥ 0.98). The mean coefficient of rolling resistance was 0.0219 and differed from 0.0205 to 0.0237 (P < 0.001) between tyres. The calculated differences in off-road speed amounted to 2.9–3.2% (0% slope) and 2.3–2.4% (10% slope) between the slowest and the fastest tyre. The reliability of the method and the differences in rolling resistance between the tyres illustrate the value of testing tyres for important competitions on a representative ground surface using the virtual elevation method.
Design, synthesis, and evaluation of cyclic C7-bridged monocarbonyl curcumin analogs containing an o-methoxy phenyl group as potential agents against gastric cancer
Creators: name: Gan, Xin
name: Wu, Yuna
name: Zhu, Min
name: Liu, Bo
name: Kong, Miaomiao
name: Xi, Zixuan
name: Li, Ke
name: Wang, Haibao
name: Su, Tiande
name: Yao, Jiali
name: Khushafah, Fatehi
name: Yi, Baozhu
name: Wang, Jiabing
name: Li, Wulan
name: Wu, Jianzhang
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biophysics
Biochemistry
Medicine
Cell Biology
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: The structure-activity relationship (SAR) between toxicity and the types of linking ketones of C7 bridged monocarbonyl curcumin analogs (MCAs) was not clear yet. In the pursuit of effective and less cytotoxic chemotherapeutics, we conducted a SAR analysis using various diketene skeletons of C7-bridged MCAs, synthesized cyclic C7-bridged MCAs containing the identified low-toxicity cyclopentanone scaffold and an o-methoxy phenyl group, and assessed their anti-gastric cancer activity and safety profile. Most compounds exhibited potent cytotoxic activities against gastric cancer cells. We developed a quantitative structure-activity relationship model (R2 > 0.82) by random Forest method, providing important information for optimizing structure. An optimized compound 2 exhibited in vitro and in vivo anti-gastric cancer activity partly through inhibiting the AKT and STAT3 pathways, and displayed a favorable in vivo safety profile. In summary, this paper provided a promising class of MCAs and a potential compound for the development of chemotherapeutic drugs.
Additional file 6: Figure S2. of Genetic diversity, linkage disequilibrium and power of a large grapevine (Vitis vinifera L) diversity panel newly designed for association studies
Creators: name: Nicolas, Stéphane
name: Péros, Jean-Pierre
name: Lacombe, Thierry
name: Launay, Amandine
name: Marie-Christine Le Paslier
name: Bérard, Aurélie
name: Mangin, Brigitte
name: Valière, Sophie
name: Martins, Frédéric
name: Cunff, Loïc Le
name: Laucou, Valérie
name: Bacilieri, Roberto
name: Dereeper, Alexis
name: Chatelet, Philippe
name: This, Patrice
name: Doligez, Agnès
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified

description: Comparison of the distribution of the r 2 VS LD values between unlinked SNPs of the four genomic regions, corrected by both structure and one of seven kinship matrices, for the whole association panel. The boxplot for r 2 is the uncorrected reference. (PDF 76 kb)
Durchstanzen von Flachdecken bei Rand- und Eckstützen
Creators: name: Brändli, Werner
Publisher: name: ETH Zurich
Year: 1985
Subjects: DURCHSTANZEN (BAUSTATIK)
FLACHDECKEN (BAUSTATIK)
BEWEHRUNG IN BETONKONSTRUKTIONEN (BAUKONSTRUKTIONSTEILE)
PUNCHING (STRUCTURAL ANALYSIS)
FLAT SLABS (STRUCTURAL ANALYSIS)
REINFORCEMENT OF CONCRETE STRUCTURES (STRUCTURAL ELEMENTS)
info:eu-repo/classification/ddc/620
Engineering & allied operations

description: Bericht / Institut für Baustatik und Konstruktion ETH Zürich, 146
description: ISBN:3-7643-1734-5
MOESM1 of Myristoylation drives dimerization of matrix protein from mouse mammary tumor virus
Creators: name: Doležal, Michal
name: Aleš Zábranský
name: Jiří Dostál
name: Ondřej Vaněk
name: Jiří Brynda
name: Lepšík, Martin
name: Hadravová, Romana
name: Pichová, Iva
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: Science Policy
subject: Plant Biology
subject: 60506 Virology

description: Additional file 1: Figure S1. MS MALDI TOF/TOF analysis of myristoylated, myr(+), and nonmyristoylated, myr(−), MMTV MA. (A) The sample of myristoylated MA contained myr(+) MA (m/z = 13006). The sample of nonmyristoylated MA contained myr(−) MA (m/z = 12795) and MA with uncleaved initial methionine (m/z = 12927). (B) To approximately determine the minimal detectable amount of myr(−) MA in the sample of myr(+) MA, the sample of myr(+) MA was mixed with the sample of myr(−) in the ratio 1000:1 (2:0.002 mg/mL). This amount of myr(−) MA was detectable whereas the sample of myr(+) contained no detectable amount of myr(−) MA.
Exploring of N-phthalimide-linked 1,2,3-triazole analogues with promising ­anti-SARS-CoV-2 activity: synthesis, biological screening, and molecular modelling studies
Creators: name: Aljuhani, Ateyatallah
name: Alsehli, Mosa
name: Seleem, Mohamed A.
name: Alraqa, Shaya Y.
name: Ahmed, Hany E. A.
name: Rezki, Nadjet
name: Aouad, Mohamed R.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: In this study, a library of phthalimide Schiff base linked to 1,4-disubstituted-1,2,3-triazoles was designed, synthesised, and characterised by different spectral analyses. All analogues have been introduced for in vitro assay of their antiviral activity against COVID-19 virus using Vero cell as incubator with different concentrations. The data revealed most of these derivatives showed potent cellular anti-COVID-19 activity and prevent viral growth by more than 90% at two different concentrations with no or weak cytotoxic effect on Vero cells. Furthermore, in vitro assay was done against this enzyme for all analogues and the results showed two of them have IC50 data by 90 µM inhibitory activity. An extensive molecular docking simulation was run to analyse their antiviral mechanism that found the proper non-covalent interaction within the Mpro protease enzyme. Finally, we profiled two reversible inhibitors, COOH and F substituted analogues that might be promising drug candidates for further development have been discovered.
Termitomorpha Wasmann 1894
Creators: name: Caron, Edilson
name: Bortoluzzi, Sidnei
name: Rosa, Cassiano S.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Staphylinidae
Termitomorpha

description: Key to the species of Termitomorpha
This key is updated from that proposed by Seevers (1957), incLuding the recent diagnostic characters of T. fissipennis (Kistner & Jacobson 1976), T. meinerti and T. huachii (Kistner 2006).
1 Outer margin of metafemur with arcuate emargination in proximal two-thirds (Kistner & Jacobson, 1976: 11, Fig. 7f)......................................................................................... T. fissipennis (Casey)
- Outer margin of metafemur normal, not as above........................................................... 2
2 Inner margin of mesofemur with conspicuous notch at the base (Kistner 2006: 623, Fig. 26e)......................... 3
- Inner margin of mesofemur normal, without notch at the base.................................................. 4
3 Mesotrochanter with a triangular projection (Kistner 2006: 623, Fig. 26e)........................... T. huachii Seevers
- Mesotrochanter normal, without projection (Kistner 2006: 627, Fig. 29b).................... T. meinerti Wasmann
4 Pronotum with sinuous lateral margin...................................................................... 5
- Pronotum with straight lateral margin..................................................................... 6
5 Mentum with apical margin almost straight............................................. T. costaricensis (Seevers)
- Mentum with apical margin conspicuously arcuate (Fig. 9)................. T. sinuosa Caron, Bortoluzzi & Rosa, sp. nov.
6 Pronotum with base strongly notched at middle (Fig. 45), wings well-developed....... T.alata Caron & Bortoluzzi, sp.nov.
- Pronotum with base slightly notched at middle, wings vestigial................................... T. manni (Seevers)
description: Published as part of Caron, Edilson, Bortoluzzi, Sidnei & Rosa, Cassiano S., 2018, Two new species of obligatory termitophilous rove beetles from Brazil (Coleoptera: Staphylinidae: Termitomorpha Wasmann), pp. 566-578 in Zootaxa 4413 (3) on page 577, DOI: 10.11646/zootaxa.4413.3.10, http://zenodo.org/record/1227839
Digitale Transformation und Human Resource Management. Trends und Perspektiven einer zukunftsgerichteten Personalarbeit in Schweizer Großunternehmen
Creators: name: Schellinger, Jochen
name: Goedermans, Marlies
name: Kolb, Lars Patrick
name: Sebai, Yassin
Publisher: name: Springer Gabler
Year: 2020

description: Die voranschreitende digitale Transformation elementarer Unternehmensprozesse schließt auch die betrieblichen Querschnittsfunktionen mit ein. Dies gilt in besonderem Maße für das Human Resource Management von Unternehmen, das sowohl als Objekt als auch als ein Treiber dieser digitalen Veränderungen in Erscheinung treten kann. Strategisch relevante Veränderungen wie Cloud Computing, Big Data und Social Media Management sowie Mobility-Trends wirken sich mittelbar und unmittelbar auch auf die Gestaltungsbereiche betrieblicher Personalarbeit aus. Der vorliegende Beitrag setzt sich theoretisch und empirisch mit der Frage nach der Relevanz und Konsequenz der Digitalisierung für das Personalmanagement in Schweizer Großunternehmen auseinander. Im Mittelpunkt steht die Vorstellung der Ergebnisse einer qualitativen Befragung von sechzehn HR-Managern führender Schweizer Großunternehmen aus verschiedensten Wirtschaftsbereichen und eines weltweit marktführenden eHR-Softwareanbieters. Grundlage hierfür war die Entwicklung eines Reifegradmodells, das versucht, die Digitalisierung anhand von acht Dimensionen des digitalen Wandels abgestuft zu spezifizieren. Die Schweizerische Unternehmenslandschaft scheint sich aufgrund der Erkenntnisse der Befragung in Bezug auf die Digitalisierung noch in einer Aufbauphase zu bewegen. Dies gilt auch hinsichtlich des Umsetzungsstands von Digital HRM-Ansätzen in den Unternehmen. Die Personalbereiche können und dürfen sich dem Digitalisierungstrend aber nicht verschließen und sollten künftig eine noch aktivere Rolle bei der Umsetzung von Digitalisierungsstrategien spielen.
Additional file 1: Table S1. of CSF complement 3 and factor H are staging biomarkers in Alzheimer’s disease
Creators: name: Hu, William
name: Watts, Kelly
name: Tailor, Prashant
name: Nguyen, Trung
name: Howell, Jennifer
name: Lee, Raven
name: Seyfried, Nicholas
name: Gearing, Marla
name: Hales, Chadwick
name: Levey, Allan
name: Lah, James
name: Lee, Eva K.
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: Demographic and biomarker information for cognitive normal subjects and MCI patients with CSF t-Tau/Aβ42 < 0.39 in the ADNI and Emory cohorts. Table S2. Main effects from mixed linear modeling of CSF FH and C3 levels in ADNI. In each model, FH or C3 was entered as the dependent variable; age, gender, presence of APOE ε4 allele, diagnosis, Aβ42, t-Tau, p-Tau181, gender X age, presence of APOE ε4 allelle X age, and diagnosis X age were entered as fixed factors; and age was also entered as a random factor. Factors with main effect p > 0.10 were removed in a step-wise fashion to arrive at final model. See text and Fig. 2 for effects from different diagnostic categories. Table S3. Mixed linear modeling of PAD-based diagnostic classification and time (in months) on longitudinal memory and executive functions in the Emory validation cohort. A) Among patients initially classified as MCI with longitudinal follow-up (n=44), reclassification using PAD showed differences in absolute executive Z-scores between those reclassified as likely MCI vs. likely mild AD, but no difference in rates of executive function decline or memory functions. B) Among patients initially classified as mild AD with longitudinal follow-up (n=10), only time was associated with longitudinal memory and executive function decline in this underpowered subgroup. (DOCX 21 kb)
Burnout and Depression Detection Using Affective Word List Ratings
Creators: name: Kurpicz-Briki, Mascha
name: Haug, Sophie
Publisher: name: IOS Press
Year: 2022

description: Burnout syndrome and depression are prevalent mental health problems in many societies today. Most existing methods used in clinical intervention and research are based on inventories. Natural Language Processing (NLP) enables new possibilities to automatically evaluate text in the context of clinical Psychology. In this paper, we show how affective word list ratings can be used to differentiate between texts indicating depression or burnout, and a control group. In particular, we show that depression and burnout show statistically significantly higher arousal than the control group.
Evaluation of N-alkyl isatins and indoles as acetylcholinesterase and butyrylcholinesterase inhibitors
Creators: name: Alcorn, Kaitlyn N.
name: Oberhauser, Isabelle A.
name: Politeski, Matthew D.
name: Eckroat, Todd J.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Cancer

description: Two series of N-alkyl isatins and N-alkyl indoles varying in size of the alkyl group were synthesised and evaluated for inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Among the N-alkyl isatins 4a-j, the addition of the N-alkyl group improved inhibition potency towards AChE and BChE compared to isatin. Selectivity towards inhibition of BChE was observed, and the increase in size of the N-alkyl group positively correlated to improved inhibition potency. The most potent inhibitor for BChE was 4i (IC50 = 3.77 µM, 22-fold selectivity for BChE over AChE). N-alkyl indoles 5a-j showed similar inhibition of AChE, the most potent being 5g (IC50 = 35.0 µM), but 5a-j lost activity towards BChE. This suggests an important role of the 3-oxo group on isatin for BChE inhibition, and molecular docking of 4i with human BChE indicates a key hydrogen bond between this group and Ser198 and His438 of the BChE catalytic triad.
Slash and Burn Agriculture, Effects of
Creators: name: Hauser, Stefan
name: Norgrove, Lindsey
Publisher: name: Elsevier
Year: 2024

description: Slash-and-burn is a generic term for agricultural systems in which the fallow vegetation is slashed, left to dry and burned before cultivating crops. Currently, 200–500 million people worldwide use slash-and-burn agriculture, and it has been estimated to cover 259 million hectares. Slash-and-burn agriculture can be sustainable if cropping phases are short and fallow length sufficient to attain full recovery of the vegetation and soil properties before another cycle. Both, destruction of the vegetation and fire are detrimental for biodiversity. However, the effects are modified by the amount of fallow biomass burned, burn intensity, relative length of the cropping and the spatial scale of burning.
Discovery of natural anthraquinones as potent inhibitors against pancreatic lipase: structure-activity relationships and inhibitory mechanism
Creators: name: Chen, Zi-Qiang
name: He, Wen-Yao
name: Yang, Si-Yuan
name: Ma, Hong-Hong
name: Zhou, Jing
name: Li, Hao
name: Zhu, Ya-Di
name: Qian, Xing-Kai
name: Zou, Li-Wei
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Hematology

description: Obesity is acknowledged as a significant risk factor for various metabolic diseases, and the inhibition of human pancreatic lipase (hPL) can impede lipid digestion and absorption, thereby offering potential benefits for obesity treatment. Anthraquinones is a kind of natural and synthetic compounds with wide application. In this study, the inhibitory effects of 31 anthraquinones on hPL were evaluated. The data shows that AQ7, AQ26, and AQ27 demonstrated significant inhibitory activity against hPL, and exhibited selectivity towards other known serine hydrolases. Then the structure-activity relationship between anthraquinones and hPL was further analysed. AQ7 was found to be a mixed inhibition of hPL through inhibition kinetics, while AQ26 and AQ27 were effective non-competitive inhibition of hPL. Molecular docking data revealed that AQ7, AQ26, and AQ27 all could associate with the site of hPL. Developing hPL inhibitors for obesity prevention and treatment could be simplified with this novel and promising lead compound.
Additional file 1: of Differential outcome of an antimicrobial stewardship audit and feedback program in two intensive care units: a controlled interrupted time series study
Creators: name: Taggart, Linda
name: Leung, Elizabeth
name: Muller, Matthew
name: Matukas, Larissa
name: Daneman, Nick
Publisher: name: Figshare
Year: 2015
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Antimicrobials Included in Overall Antimicrobial Use and Cost. Antimicrobials Included in Overall Antimicrobial Use and Cost (PDF 206 kb)
Novel NO-TZDs and trimethoxychalcone-based DHPMs: design, synthesis, and biological evaluation as potential VEGFR-2 inhibitors
Creators: name: Mahnashi, Mater H.
name: Nahari, Mohammed
name: Almasoudi, Hassan
name: Alhasaniah, Abdulaziz
name: Elgazwi, Sara
name: Abou-Salim, Mahrous A.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Novel series of nitric oxide-releasing thiazolidine-2,4-diones (NO-TZD-3a-d,5,6) and 3,4,5-trimethoxychalcone-based multifunctional 1,4-dihydropyrimidines (CDHPM-10a-g) have been designed and synthesised as potent broad-spectrum anticancer agents with potential VEGFR-2 inhibition. The designed analogs were evaluated for their anticancer activities towards a full panel of NCI-60 tumour cell lines and CDHPM-10a-g emerged mean %inhibitions ranging from 76.40 to 147.69%. Among them, CDHPM-10e and CDHPM-10f demonstrated the highest MGI% of 147.69 and 140.24%, respectively. Compounds CDHPM-10a,b,d-f showed higher mean %inhibitory activity than the reference drug sorafenib (MGI% = 105.46%). Superiorly, the hybrid CDHPM-10e displayed the highest potencies towards all the herein tested subpanels of nine types of cancer with MGI50 of 1.83 µM. Also, it revealed potent cytostatic single-digit micromolar activity towards the herein examined cancer cell lines. The designed compounds CDHPM-10a-g were exposed as potent non-selective broad-spectrum anticancer agents over all NCI subpanels with an SI range of 0.66–1.97. In addition, the target analog CDHPM-10e revealed potency towards VEGFR-2 kinase comparable to that of sorafenib with a sub-micromolar IC50 value of 0.11 µM. Also, CDHPM-10e could effectively induce Sub-G1-phase arrest and prompt apoptosis via caspase and p53-dependent mechanisms. Furthermore, CDHPM-10e revealed significant anti-metastatic activity as detected by wound healing assay. The modelling study implies that CDHPM-10e overlaid well with sorafenib and formed a strong H-bond in the DFG binding domain. The ADMET studies hinted out that CDHPM-10e met Pfizer’s drug-likeness criteria. The presented novel potent anticancer agent merits further devotion as a new lead product in developing more chalcone-based VEGFR-2 inhibitors.
Additional file 3: of Phylogenetic and amino acid conservation analyses of bacterial l-aspartate-Îą-decarboxylase and of its zymogen-maturation protein reveal a putative interaction domain
Creators: name: Stuecker, Tara
name: Bramhacharya, Shanti
name: Hodge-Hanson, Kelsey
name: Suen, Garret
name: Escalante-Semerena, Jorge
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Table S1. Bacteria from which panD genes were amplified and cloned.
IV Curve Tracer
Creators: name: Müller, Mischa Benjamin
name: Borgna, Luciano
name: Spring, Sina Julia
name: Bucher, Christof
Year: 2022

description: In diesem Poster wird ein neu entwickelter IV-Curve Tracer (IVCT) vorgestellt, der parallel zu einem handelsüblichen Modulwechselrichter (WR) betrieben wird. Die PV-Modulkennlinie wird in weniger als200 ms gemessen, so dass der WR keinen Betriebsunterbruch feststellen kann. Der IVCT wurde im Rahmen einer Bachelorarbeit am PV-Labor der BFH entwickelt und zeigt in der ersten Testphase eine hohe Genauigkeit von 0.5%.
Additional file 3: of Muscarinic M1 receptors modulate endotoxemia-induced loss of synaptic plasticity
Creators: name: Zivkovic, Aleksandar
name: Sedlaczek, Oliver
name: Haken, Rebecca Von
name: Schmidt, Karsten
name: Brenner, Thorsten
name: Weigand, Markus
name: Bading, Hilmar
name: C. Bengtson
name: Hofer, Stefan
Publisher: name: Figshare
Year: 2015
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Results summary. Tables show measured values from all experiments in this study. Data is presented as meanâ  Âąâ  SEM. (PDF 31 kb)
Additional file 1: of Using program evaluation to support knowledge translation in an interprofessional primary care team: a case study
Creators: name: Donnelly, Catherine
name: Shulha, Lyn
name: Klinger, Don
name: Letts, Lori
Publisher: name: Figshare
Year: 2016
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 60506 Virology

description: Memory Clinic Knowledge Questionnaire. Word Document (DOCX 16 kb)
Palindromic carbazole derivatives: unveiling their antiproliferative effect via topoisomerase II catalytic inhibition and apoptosis induction
Creators: name: Olszewski, Mateusz
name: Maciejewska, Natalia
name: Kallingal, Anoop
name: Chylewska, Agnieszka
name: Dąbrowska, Aleksandra M.
name: Biedulska, Małgorzata
name: Makowski, Mariusz
name: Padrón, José M.
name: Baginski, Maciej
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Human DNA topoisomerases are essential for crucial cellular processes, including DNA replication, transcription, chromatin condensation, and maintenance of its structure. One of the significant strategies employed in cancer treatment involves the inhibition of a specific type of topoisomerase, known as topoisomerase II (Topo II). Carbazole derivatives, recognised for their varied biological activities, have recently become a significant focus in oncological research. This study assesses the efficacy of three symmetrically substituted carbazole derivatives: 2,7-Di(2-furyl)-9H-carbazole (27a), 3,6-Di(2-furyl)-9H-carbazole (36a), and 3,6-Di(2-thienyl)-9H-carbazole (36b) – as anticancer agents. Among investigated carbazole derivatives, compound 3,6-di(2-furyl)-9H-carbazole bearing two furan moieties emerged as a novel catalytic inhibitor of Topo II. Notably, 3,6-di(2-furyl)-9H-carbazole effectively selectively inhibited the relaxation and decatenation activities of Topo IIα, with minimal effects on the IIβ isoform. These findings underscore the potential of compound 3,6-Di(2-furyl)-9H-carbazole as a promising lead candidate warranting further investigation in the realm of anticancer drug development.
title: Familiale Pflege als Angelegenheit der Frauen?
title: Diskursive Deutungen zur Zukunft der Altenfürsorge und -pflege
titleType: Subtitle
Creators: name: Kunstmann, Anne-Christine
Publisher: name: Verlag Barbara Budrich
Year: 2010
Subjects: subject: Pflege
subject: Alter
subject: Geschlechtergerechtigkeit
subject: 300 Sozialwissenschaften

description: Aufgezeigt wird, dass und wie familiale Pflege und Fürsorge für hilfsbedürftige alte Angehörige diskursiv als „Angelegenheit der Frauen“ interpretiert und institutionalisiert wird, ohne die Frage der Geschlechtergerechtigkeit zu thematisieren. In diesem Beitrag wird dies durch eine Re- und Dekonstruktion der These verdeutlicht, die Zukunft der Altenfürsorge und -pflege sei prekär, weil Frauen in ihrer Bereitschaft zur Übernahme von Verantwortung nachlassen würden. Kritisch diskutiert werden dabei die Orientierung an der traditionellen Generationenethik, die Verknüpfung von Generationen- und Geschlechtervertrag, die Modernisierung von Lebensentwürfen, die Dilemmata rationaler Lebensplanung, sowie die Konflikte pflegender Frauen.
Development of novel ALOX15 inhibitors combining dual machine learning filtering and fragment substitution optimisation approaches, molecular docking and dynamic simulation methods
Creators: name: Liao, Yinglin
name: Cao, Peng
name: Luo, Lianxiang
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biophysics
Biochemistry
Medicine
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Mathematical Sciences not elsewhere classified

description: The oxidation of unsaturated lipids, facilitated by the enzyme Arachidonic acid 15-lipoxygenase (ALOX15), is an essential element in the development of ferroptosis. This study combined a dual-score exclusion strategy with high-throughput virtual screening, naive Bayesian and recursive partitioning machine learning models, the already established ALOX15 inhibitor i472, and a docking-based fragment substitution optimisation approach to identify potential ALOX15 inhibitors, ultimately leading to the discovery of three FDA-approved drugs that demonstrate optimal inhibitory potential against ALOX15. Through fragment substitution-based optimisation, seven new inhibitor structures have been developed. To evaluate their practicality, ADMET predictions and molecular dynamics simulations were performed. In conclusion, the compounds found in this study provide a novel approach to combat conditions related to ferroptosis-related injury by inhibiting ALOX15.
Targeting bacterial growth in biofilm conditions: rational design of novel inhibitors to mitigate clinical and food contamination using QSAR
Creators: name: Galvez-Llompart, Maria
name: Hierrezuelo, Jesús
name: Blasco, Mariluz
name: Zanni, Riccardo
name: Galvez, Jorge
name: de Vicente, Antonio
name: Pérez-García, Alejandro
name: Romero, Diego
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Antimicrobial resistance (AMR) is a pressing global issue exacerbated by the abuse of antibiotics and the formation of bacterial biofilms, which cause up to 80% of human bacterial infections. This study presents a computational strategy to address AMR by developing three novel quantitative structure–activity relationship (QSAR) models based on molecular topology to identify potential anti-biofilm and antibacterial agents. The models aim to determine the chemo-topological pattern of Gram (+) antibacterial, Gram (−) antibacterial, and biofilm formation inhibition activity. The models were applied to the virtual screening of a commercial chemical database, resulting in the selection of 58 compounds. Subsequent in vitro assays showed that three of these compounds exhibited the most promising antibacterial activity, with potential applications in enhancing food and medical device safety.
Aetana Huber 2005
Creators: name: Huber, Bernhard A.
name: Carvalho, Leonardo S.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Pholcidae
Aetana

description: Aetana Huber, 2005
Aetana Huber, 2005b: 72; type species by original designation: A. omayan Huber, 2005.
Aetana — Huber et al. 2015a: 4.
Notes. The genus has been revised recently, and cladistic analysis of morphological characters suggested the existence of four species groups (Huber et al. 2015a). Molecular data have corroborated both the species groups and the monophyly of the genus (Eberle et al. 2018; Huber et al. 2018). However, the species newly described below were not clearly assigned to any of the four species groups; there were placed as sister to the kinabalu group, but with low support. Morphological data rather suggest a close relationship with the omayan group. Three of the four synapomorphies identified for this group in Huber et al. (2015a) are present in the three new species below: male clypeus with pair of apophyses; very long male cheliceral apophyses; and presence of female stridulatory apparatus between carapace and abdomen. The fourth synapomorphy (pair of pockets in area behind epigynum) is poorly visible in most species and appears to be present in at least one of the new species (A. ondawamei; Fig. 287).
The unnamed species from Halmahera shown in the distribution map in Huber et al. (2015a: fig. 2; “ A. sp. 1”) is in fact two similar species. They are apparently closely related to the three species described below. They are represented by only one poorly preserved male specimen each (in Bernice P. Bishop Museum, Honolulu, Hawaii) and thus remain undescribed.
The original diagnosis and description of the genus are still largely valid. The new species A. mokwam is now the largest known representative of the genus and extends the body length range to ~2.5–5.0; male leg 1 length to ~27–50; male tibia 1 length to ~6.0–12.4; female tibia 1 length to ~4.0–10.7.
description: Published as part of Huber, Bernhard A. & Carvalho, Leonardo S., 2019, Filling the gaps: descriptions of unnamed species included in the latest molecular phylogeny of Pholcidae (Araneae), pp. 1-96 in Zootaxa 4546 (1) on page 71, DOI: 10.11646/zootaxa.4546.1.1, http://zenodo.org/record/2619020
Suppression of lipopolysaccharide-induced COX-2 expression via p38MAPK, JNK, and C/EBPβ phosphorylation inhibition by furomagydarin A, a benzofuran glycoside from Magydaris pastinacea
Creators: name: Huang, Shiu-Wen
name: Hsu, Ming Jen
name: Chen, Hsiu-Chen
name: Meleddu, Rita
name: Distinto, Simona
name: Maccioni, Elias
name: Cottiglia, Filippo
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Infectious Diseases
subject: FOS: Health sciences

description: The phytochemical investigation of the methanol extract of the seeds of Magydaris pastinacea afforded two undescribed benzofuran glycosides, furomagydarins A-B (1, 2), together with three known coumarins. The structures of the new isolates were elucidated after extensive 1D and 2D NMR experiments as well as HR MS. Compound 1 was able to inhibit the COX-2 expression in RAW264.7 macrophages exposed to lipopolysaccharide, a pro-inflammatory stimulus. RT-qPCR and luciferase reporter assays suggested that compound 1 reduces COX-2 expression at the transcriptional level. Further studies highlighted the capability of compound 1 to suppress the LPS-induced p38MAPK, JNK, and C/EBPβ phosphorylation, leading to COX-2 down-regulation in RAW264.7 macrophages.
Denkmalpflege braucht Menschen. Wege zu einer partizipativen Denkmalpflege
Creators: name: Mekacher, Nina
Publisher: name: Seismo
Year: 2019

description: Denkmalpflege wird in der Schweiz von heute in erster Linie als hoheitliche Aufgabe der Kantone verstanden und gelebt. Sie kennt zwar durchaus aktive Teilhabe und Bürgerbeteiligung. Dabei kommt traditionsreichen Non-Profit-Organisationen wie der Gesellschaft für Schweizerische Kunstgeschichte oder dem Schweizer Heimatschutz eine wichtige Rolle zu. Diese verkörpern aber nur ein kleines, ausgewähltes Segment der Gesellschaft. Die Denkmalpflege agiert zunehmend im geschlossenen System und bekundet Mühe, an gesellschaftsrelevante, fachexterne Diskurse anzuschliessen. Methoden, Instrumente und theoretische Grundlagen werden den kulturellen Werten der heterogenen Gesellschaft nicht mehr gerecht. Soll Denkmalpflege als gesamtgesellschaftliche Aufgabe relevant bleiben, so muss ihre Tätigkeit von möglichst vielen Menschen als sinnstiftend wahrgenommen werden. Dieser Prozess kann durch systematische Erweiterung der Teilhabe angestossen werden. Das bedingt ein Umdenken. Macht muss geteilt, Verantwortung eingefordert und Vertrauen geschaffen werden.
POLITICAL FINANCE AND 2023 GENERAL ELECTIONS IN NIGERIA
Creators: name: Olajide Olufunsho, Ayobolu
Publisher: name: ZAP JOURNALS
Year: 2024
Subjects: Political finance, Election, INEC, Nigeria

description: Political finance is an important issue when discussing the 2023 general elections in Nigeria. There is no doubt that the use of enormous sums of money played a significant role in who emerged as key players in the aftermath of the election. This stems from the use of big money in different primaries of big political parties, the exorbitant prices of expression of interest and nomination forms, as well as various political campaigns across the length and breadth of the country. The sources of most of these funds are shrouded in secrecy and were often discussed in hush tones. However, there is no doubt that public funds were dissipated on electoral matters, and of course, illicit funds cannot be ruled out. The perception is derivable from the fact that political power during the period in question was pursued with deadly seriousness. Everything humanly possible was done by the occupiers of office to retain their political offices at all costs while, preventing others from coming on board. There were several cases of vote buying, vote selling and vote trading by all political parties, as the whole political spectrum of the country was thrown into an orgy of political parties’ financial bazaar. The threshold of political finance stipulated by the electoral law books were wantonly disregarded and there were no concrete steps taken by the appropriate authorities to bring the electoral offenders to book. The use of big money altered the level playing field in favour of the biggest spenders and financially well-to-do political parties. It is imperative to underscore the fact that the research methodology adopted was the descriptive method and the theoretical framework used was clientelism, after which a conclusion was drawn and recommendations presented.
Why we thought it was a good idea to build a DACH games database
Creators: name: Pfister, Eugen
name: Demleitner, Adrian
Publisher: name: Zenodo
Year: 2023

description: Eugen Pfister and Adrian Demleitner held a presentation at the German Literature Archive (DLA) in Marbach on the topic of building a database for digital games that were developed or are related to the German-speaking countries.
Boronic acid inhibitors of penicillin-binding protein 1b: serine and lysine labelling agents
Creators: name: Kollár, Levente
name: Grabrijan, Katarina
name: Rambaher, Martina Hrast
name: Bozovičar, Krištof
name: Imre, Tímea
name: Ferenczy, György G.
name: Gobec, Stanislav
name: Keserű, György M.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Penicillin-binding proteins (PBPs) contribute to bacterial cell wall biosynthesis and are targets of antibacterial agents. Here, we investigated PBP1b inhibition by boronic acid derivatives. Chemical starting points were identified by structure-based virtual screening and aliphatic boronic acids were selected for further investigations. Structure–activity relationship studies focusing on the branching of the boron-connecting carbon and quantum mechanical/molecular mechanical simulations showed that reaction barrier free energies are compatible with fast reversible covalent binding and small or missing reaction free energies limit the inhibitory activity of the investigated boronic acid derivatives. Therefore, covalent labelling of the lysine residue of the catalytic dyad was also investigated. Compounds with a carbonyl warhead and an appropriately positioned boronic acid moiety were shown to inhibit and covalently label PBP1b. Reversible covalent labelling of the catalytic lysine by imine formation and the stabilisation of the imine by dative N–B bond is a new strategy for PBP1b inhibition. Penicillin-binding protein (PBP) 1b is an antibacterial target with a serine-lysine catalytic dyad. Covalent boronic acid inhibitors targeting the serine residue and compounds containing both a boronic acid moiety and a carbonyl group targeting the lysine residue with a concomitant dative N–B bond formation were studied. Structure-activity studies were combined with QM/M free energy calculations to explore the mechanism of covalent inhibition.
Additional file 1: Table S1. of Transplantation of hESC-derived hepatocytes protects mice from liver injury
Creators: name: Tolosa, Laia
name: Caron, Jérôme
name: Hannoun, Zara
name: Antoni, Marc
name: López, Silvia
name: Burks, Deborah
name: Castell, Jose
name: Weber, Anne
name: Maria-Jose Gomez-Lechon
name: Dubart-Kupperschmitt, Anne
Publisher: name: Figshare
Year: 2015
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology

description: Antibodies used in this study. (PDF 48.5 KB)