cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Immersed boundary-finite element model of fluid–structure interaction in the aortic root
Creators: name: DeAnda, Abe
name: Flamini, Vittoria
name: Griffith, Boyce E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: It has long been recognized that aortic root elasticity helps to ensure efficient aortic valve closure, but our understanding of the functional importance of the elasticity and geometry of the aortic root continues to e-volve as increasingly detailed in vivo imaging data become available. Herein, we describe a fluid-structure interaction model of the aortic root, including the aortic valve leaflets, the sinsuses of Valsalva, the aortic annulus, and the sinotubular junction, that employs a version of Peskin’s immersed boundary (IB) method with a finite element (FE) description of the structural elasticity. As in earlier work, we use a fiber-based model of the valve leaflets, but this study extends earlier IB models of the aortic root by employing an incompressible hyperelastic model of the mechanics of the sinuses and ascending aorta using a constitutive law fit to experimental data from human aortic root tissue. In vivo pressure loading is accounted for by a backward displacement method that determines the unloaded configurations of the root model. Our model yields realistic cardiac output at physiological pressures, with low transvalvular pressure differences during forward flow, minimal regurgitation during valve closure, and realistic pressure loads when the valve is closed during diastole. Further, results from high-resolution computations indicate that although the detailed leaflet and root kinematics show some grid sensitivity, our IB model of the aortic root nonetheless produces essentially grid-converged flow rates and pressures at practical grid spacings for the high-Reynolds number flows of the aortic root. These results thereby clarify minimum grid resolutions required by such models when used as stand-alone models of the aortic valve as well as when used to provide models of the outflow valves in models of left ventricular fluid dynamics.
Amtliche Mitteilungen der Technischen Universität Dortmund Nr. 23/2023
Creators: name: (:Unkn) Unknown
Publisher: name: Technische Universität Dortmund
Year: 2023
Subjects: subject: 080

description: Dienstvereinbarung zur gleitenden Arbeitszeit an der Technischen Universität Dortmund
description: Amtliche Mitteilungen der Technischen Universität Dortmund;2023; 23
Impact of ground conditions and excavation depth on selection of excavation support system
Creators: name: El-Kelesh, Adel M.
name: Hassan, Dena A.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Inappropriate selection of an excavation support system (ESS) may lead to delays, cost overruns and quality and safety problems. Soil conditions, excavation depth and groundwater level are important factors that significantly affect the selection of ESS. However, a guideline that determines the effects of these three factors and accounts for their variation in the selection of ESS is not available. To evaluate such effects, a questionnaire was sent to excavation support experts worldwide. The results of the conducted survey are presented and discussed in the current paper to determine the favourable soil conditions and maximum excavation depths for ESS in dry and wet soils. The focus is on the soldier pile, secant pile, diaphragm and jet grout walls because of their common use worldwide. Clear guidelines that can help in the selection of an appropriate ESS for given site conditions could be established. The obtained findings are compared with the conditions and adopted ESS of reported case histories.
ATP-Responsive and Near-Infrared-Emissive Nanocarriers for Anticancer Drug Delivery and Real-Time Imaging
Creators: name: Zhu, Sha
name: Yu, Jicheng
name: Gu, Zhen
name: Tang, Xin
name: Qian, Chenggen
name: Sun, Wujin
name: Zhang, Lei
name: Shen, Qun-Dong
name: Xiao, Xuanzhong
name: Hu, Quanyin
name: Lu, Yue
name: Chen, Yulei
name: Feng, Peijian
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Stimuli-responsive and imaging-guided drug delivery systems hold vast promise for enhancement of therapeutic efficacy. Here we report an adenosine-5'-triphosphate (ATP)-responsive and near-infrared (NIR)-emissive conjugated polymer-based nanocarrier for the controlled release of anticancer drugs and real-time imaging. We demonstrate that the conjugated polymeric nanocarriers functionalized with phenylboronic acid tags on surface as binding sites for ATP could be converted to the water-soluble conjugated polyelectrolytes in an ATP-rich environment, which promotes the disassembly of the drug carrier and subsequent release of the cargo. In vivo studies validate that this formulation exhibits promising capability for inhibition of tumor growth. We also evaluate the metabolism process by monitoring the fluorescence signal of the conjugated polymer through the in vivo NIR imaging.
Casimir-Polder force for a polarizable molecule near a dielectric substrate out of thermal equilibrium
Creators: name: Zhou, Wenting
name: Yu, Hongwei
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We demonstrate that the Casimir-Polder force for a molecule near the surface of a real dielectric substrate out of thermal equilibrium displays distinctive behaviors as compared to that at thermal equilibrium. In particular, when the molecule-substrate separation is much less than the molecular transition wave-length, the CP force in the high temperature limit can be dramatically manipulated by varying the relative magnitude of the temperatures of the substrate and the environment so that the attractive-to-repulsive transition can occur beyond certain a threshold temperature of either the substrate or the environment depending on which one is higher for molecules both in the ground and excited states. More remarkably, when the separation is comparable to the wave-length, such transitions which are impossible at thermal equilibrium may happen for longitudinally polarizable molecules with a small permittivity, while for isotropically polarizable ones the transitions can even occur at room temperature for some dielectric substrates such as sapphire and graphite which is much lower than the temperature for the transition to take place in the thermal equilibrium case, thus making the experimental demonstration of such force transitions easier.
description: 13 pages, 6 figures, to appear in PRA
Large-scale jets in the magnetosheath and plasma penetration across the magnetopause: THEMIS observations
Creators: name: Dmitriev, A. V.
name: Suvorova, A. V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: THEMIS multi-point observation of the plasma and magnetic fields, conducted simultaneously in the dayside magnetosheath and magnetosphere, were used to collect 646 large-scale magnetosheath plasma jets interacting with the magnetopause. The jets were identified as dense and fast streams of the magnetosheath plasma whose energy density is higher than that of the upstream solar wind. The jet interaction with the magnetopause was revealed from sudden inward motion of the magnetopause and an enhancement in the geomagnetic field. The penetration was determined as appearance of the magnetosheath plasma against the background of the hot magnetospheric particle population. We found that almost 60% of the jets penetrated through the magnetopause. Vast majority of the penetrating jets was characterized by high velocities V > 220 km/s and kinetic bk > 1 that corresponded to a combination of finite Larmor radius effect with a mechanisms of impulsive penetration. The average plasma flux in the penetrating jets was found to be 1.5 times larger than the average plasma flux of the solar wind. The average rate of jet-related penetration of the magnetosheath plasma into the dayside magnetosphere was estimated to be ~10^29 particles per day. The rate varies highly with time and can achieve values of 1.5*10^29 particles per hour that is comparable with estimates of the total amount of plasma entering the dayside magnetosphere.
description: 12 figures
Eupatorium vauthierianum var. trichotomum Baker
Creators: name: Chocarro, María Del Carmen Peña
name: Egea, Juana De
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Asterales
Asteraceae
Eupatorium
Eupatorium vauthierianum
Eupatorium vauthierianum dc. var. trichotomum baker

description: Eupatorium vauthierianum DC. var. trichotomum Baker
Distribution: Brazil, Paraguay.
 Source: Cabrera et al. 1996.
description: Published as part of Chocarro, María Del Carmen Peña & Egea, Juana De, 2018, Checklist of the endemic vascular plants of Paraguay, pp. 448-450 in Phytotaxa 384 (1) on pages 448-450, DOI: 10.11646/phytotaxa.384.1.1, http://zenodo.org/record/13725946
On the Implications of Recent Observations of the Inner Knot in the Crab Nebula
Creators: name: Yuan, Yajie
name: Blandford, Roger
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Recent observations of the Crab Nebula (Rudy et al 2015) have maintained its reputation for high energy astrophysical enlightenment and its use as a testbed for theories of the behaviour of magnetized, relativistic plasma. In particular, new observations of the inner knot located 0.65" SE from the pulsar confirm that it is compact, elongated transversely to the symmetry axis and curved concave towards the pulsar. 60 percent polarization has been measured along the symmetry axis (Moran et al 2013). The knot does not appear to be involved in the gamma ray flares. The new observations both reinforce the interpretation of the knot as dissipation of the pulsar wind at a strong shock and challenge the details of existing models of this process. In particular, it is argued that the compactness, high polarization and curvature are difficult to reconcile with simple relativistic shock models. Alternative possibilities include deflection of the outflow ahead of the shock and spatial variation in which the knot is interpreted as a caustic. Some future observations are proposed and new theoretical investigations are suggested.
description: 17 pages, 13 figures. Published in MNRAS
title: One for All and All for One, None for Many and Many for None: Understanding Solidarity in the Common European Asylum System.
Creators: name: Gray, HL
Publisher: name: University of Liverpool Repository
Year: 2018

description: The European Union’s asylum law and policy has been founded on the principle of solidarity between the Member States. The Treaty of Lisbon cemented this principle in the primary law of the EU at Article 80 of the Treaty on the Functioning of the European Union and its priority has been re-emphasised in reactions to Europe’s ‘refugee crisis’. Solidarity is offered as an intuitively simple and constructive solution to the challenges facing the Common European Asylum System (CEAS). Yet it remains unclear what exactly this entails, as a definition of solidarity is conspicuously absent despite the central role it plays. This absence of a shared understanding makes it very difficult to engage meaningfully with legal or political calls for solidarity and to evaluate or critique the CEAS based on solidarity. This thesis critically investigates the meaning of solidarity in the context of the Common European Asylum System. The first part finds that solidarity conveys numerous different meanings and is used to express these variably at different times, established by drawing on three sources: first, the normative and theoretical underpinnings of the idea of solidarity; second, the development of solidarity in and by the European Union; and third, solidarity or burden-sharing in refugee law and practice through international and regional configurations. This flexibility is used to interpret solidarity in the CEAS in the second part: first to interrogate the contents of the ‘solidarity toolbox’ of practical, financial and legal mechanisms expressing the principle; and second to reflect on its role in shaping the CEAS and in managing the relationships between the EU, the Member States, and persons in need of international protection. From this, it is argued that solidarity does not necessarily entail any specific policy choices, rather, diverse policy options might equally claim to be based on the principle of solidarity. This enables the principle of solidarity to act as a point of agreement for actors with diverse interests and visions for asylum policy, but prevents solidarity guiding CEAS law and policymaking beyond this superficial agreement. Solidarity is a deceptively simple and alluring foundation and problem-solving tool for the CEAS. Its flexibility allows it to offer a veneer of unity to the CEAS, accommodating diverse, even conflicting, visions. On the other hand, this flexibility also means that it is a largely empty vessel and severely limited in its practical ability to guide law and policy planning in the CEAS.
Control of mesoscopic transport by modifying transmission channels in opaque media
Creators: name: Sarma, Raktim
name: Yamilov, Alexey
name: Liew, Seng Fatt
name: Guy, Mikhael
name: Cao, Hui
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: While controlling particle diffusion in a confined geometry is a popular approach taken by both natural and artificial systems, it has not been widely adopted for controlling light transport in random media, where wave interference effects play a critical role. The transmission eigenchannels determine not only light propagation through the disordered system but also the energy concentrated inside. Here we propose and demonstrate an effective approach to modify these channels, whose structures are considered to be universal in conventional diffusive waveguides. By adjusting the waveguide geometry, we are able to alter the spatial profiles of the transmission eigenchannels significantly and deterministically from the universal ones. In addition, propagating channels may be converted to evanescent channels or vice versa by tapering the waveguide cross-section. Our approach allows to control not only the transmitted and reflected light, but also the depth profile of energy density inside the scattering system. In particular geometries perfect reflection channels are created, and their large penetration depth into the turbid medium as well as the complete return of probe light to the input end would greatly benefit sensing and imaging applications. Absorption along with geometry can be further employed for tuning the decay length of energy flux inside the random system, which cannot be achieved in a common waveguide with uniform cross-section. Our approach relies solely on confined geometry and does not require any modification of intrinsic disorder, thus it is applicable to a variety of systems and also to other types of waves.
Conformationally Strained trans- Cyclooctene (sTCO) Enables the Rapid Construction of 18 F-PET Probes via Tetrazine Ligation
Creators: name: Wang, Mengzhe
name: Svatunek, Dennis
name: Yuan, Hong
name: Fox, Joseph
name: Rohlfing, Katarina
name: Wu, Zhanghong
name: Li, Zibo
name: Giglio, Ben
name: Liu, Yu
name: Wang, Hui
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The bioorthogonal reaction between tetrazines and trans-cyclooctenes is a method for the rapid construction of F-18 probes for PET imaging. Described here is a second generation 18F-labeling system based on a conformationally strained trans-cyclooctene (sTCO)—a dienophile that is approximately 2 orders of magnitude more reactive than conventional TCO dienophiles. Starting from a readily prepared tosylate precursor, an 18F labeled sTCO derivative (18F-sTCO) could be synthesized in 29.3 +/- 5.1% isolated yield and with high specific activity. Tetrazine ligation was carried out with a cyclic RGD-conjugate of a diphenyl-s-tetrazine analogue (RGD-Tz) chosen from a diene class with an excellent combination of fast reactivity and stability both for the diene as well as the Diels-Alder adduct. For both the tetrazine and the sTCO, mini-PEG spacers were included to enhance solubility and improve the in vivo distribution profile of the resulting probe. Extremely fast reactivity (up to 2.86 x 105 M-1s-1 at 25 °C in water) has been observed in kinetic studies in the reaction of sTCO with diphenyl-s-tetrazine derivatives. A kinetic study on sTCO diastereomers in 55:45 MeOH:water showed that the syn-diastereomer displayed slightly faster reactivity than the anti-diastereomer. An 18F-sTCO conjugate with RGD-Tz demonstrated prominent and persistent tumor uptake in vivo with good tumor-to-background contrast. Unlike most radiolabeled RGD peptides, the tumor uptake of this PET agent increased from 5.3 +/- 0.2% ID/g at 1 h post injection (p.i.), to 8.9 +/- 0.5% ID/g at 4 h p.i., providing evidence for prolonged blood circulation. These findings suggest that tetrazine ligations employing 18F-sTCO should serve as a powerful and general platform for the rapid construction of peptide or protein derived PET agents.
Quasirelativistic calculation of 4s$^2$4p$^5$, 4s$^2$4p$^4$4d and 4s4p$^6$ configuration spectroscopic parameters for the W$^{39+}$ ion
Creators: name: Bogdanovich, P.
name: Karpuškienė, R.
name: Kisielius, R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: The ab initio quasirelativistic Hartree-Fock method developed specifically for the calculation of spectral parameters of heavy atoms and highly charged ions is used to derive spectral data for the 4s$^2$4p$^5$, 4s$^2$4p$^4$4d and 4s4p$^6$ configurations of the multicharged tungsten ion W$^{39+}$. The relativistic effects are taken into account in the Breit-Pauli approximation for the quasirelativistic Hartree-Fock radial orbitals. The configuration interaction method is applied to include the electron correlation effects. Produced data are compared with existing experimental measurements and theoretical calculations.
Pekar's Ansatz and the Strong Coupling Problem in Polaron Theory
Creators: name: Lakhno, V. D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: A detailed consideration is given to the translation-invariant theory of Tulub polaron constructed without the use of Pekar ansatz. A fundamental result of the theory is that the value of the polaron energy is lower than that obtained on the basis of Pekar ansatz which was considered as an asymptotically exact solution in the strong coupling limit. In the case of bipolarons the theory yields the best values of the coupling energy and critical parameters of their stability. Numerous physical consequences of the existence of translation-invariant polarons and bipolarons are discussed.
description: 35 pages, 4 figures. Physics-Uspekhi (Advances in Physical Sciences), 2015, accepted. Draft version
Current and Future Theranostic Applications of the Lipid-Calcium-Phosphate Nanoparticle Platform
Creators: name: Satterlee, Andrew B.
name: Huang, Leaf
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Over the last four years, the Lipid-Calcium-Phosphate (LCP) nanoparticle platform has shown success in a wide range of treatment strategies, recently including theranostics. The high specific drug loading of radiometals into LCP, coupled with its ability to efficiently encapsulate many types of cytotoxic agents, allows a broad range of theranostic applications, many of which are yet unexplored. In addition to providing an overview of current medical imaging modalities, this review highlights the current theranostic applications for LCP using SPECT and PET, and discusses potential future uses of the platform by comparing it with both systemically and locally delivered clinical radiotherapy options as well as introducing its applications as an MRI contrast agent. Strengths and weaknesses of LCP and of nanoparticles in general are discussed, as well as caveats regarding the use of fluorescence to determine the accumulation or biodistribution of a probe.
Functional microRNA screening for dietary vitamin E regulation of abdominal fat deposition in broilers
Creators: name: Zhang, Min
name: Liu, Lingyu
name: Chen, Donghong
name: Zhang, Xuemei
name: Zhou, Chenxin
name: Gan, Qiuyun
name: Li, Yan
name: Wu, Qiong
name: Li, Hongyi
name: Xu, Weihua
name: Zhang, Mao
name: Huang, Qichun
name: Sun, Yanfa
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Mental Health
subject: Computational Biology

description: 1. Functional microRNA (miRNA) screening for abdominal fat tissue with different dietary vitamin E (VE) levels was performed to reveal miRNAs, genes and metabolic pathways involved in abdominal fat deposition in broilers. 2. A total of 240, one-day-old healthy female chicks were randomly allocated into five dietary treatments containing either 0, 20, 50, 75 or 100 IU DL-α-tocopherol acetate. The sequencing of miRNAs from abdominal fat tissues was performed. The target genes of miRNAs were predicted and enrichment analysis for these genes was performed. Diets supplemented with 50 IU VE significantly diminished abdominal fat deposition in broilers at day 35 of age. 3. A total of 29 miRNAs were differentially expressed between control and 50 IU VE treatment. Ten of the 23 target genes were enriched in four signalling pathways: tight junction, SNARE interactions in vesicular transport, regulation of autophagy and proteasome. 4. This study identified miRNA, target genes and pathways in dietary VE treatment for broilers, providing new insights into the miRNA regulation of abdominal fat deposition in broilers.
title: Bayesian Methods for Protein Quantification in Mass Spectrometry Proteomics
Creators: name: Phillips, Alexander
Publisher: name: University of Liverpool Repository
Year: 2020

description: Current workflows in mass spectrometry proteomics are able to identify thousands of proteins in a single biological sample by breaking them down through enzymatic digestion into smaller molecules, peptides. Quantification of the differences in abundances of proteins between populations is based on measurements of these peptides at multiple charge states, features. Subsequent determination of significant changes in the abundance of proteins between those populations remains a challenge. This is complicated further by the presence of shared peptides arising from multiple proteins. This PhD thesis explores some of the statistical modelling challenges associated with the quantification of proteins in mass spectrometry proteomics. Firstly, an overview of the existing literature is presented, focusing on current methods for quantifying proteins and differential expression analysis. A current Bayesian pipeline for quantifying proteins from feature-level data using Markov chain Monte Carlo sampling is then evaluated. A method by which sampling might be made more efficient by exploiting conjugate distributions is then proposed. Similar conjugate analysis is then applied to the specific problem of differential expression analysis. The analytic nature of the resulting model is exploited to achieve fast inference without the need for computationally expensive numerical integration. This enables a model comparison approach to statistical testing, with the aim of achieving calibrated estimates of false discovery rate. A Bayesian hierarchical model is then proposed for the analysis of shared peptides. Finally, overarching conclusions are drawn and recommendations for future research are discussed.
Handy Misunderstandings. Experts, Professionals and Laypersons Relationships
Creators: name: Trépos, Jean-Yves
Publisher: name: Cambio. Rivista sulle Trasformazioni Sociali
Year: 2016

description: If one is to assume a changing role for rationalization in contemporary collectives, how may we consider the relationship between expertise and professionalism? It can be affected by three challenges: maintaining the classical domination of experts; trying to cope with counter-expertise and conflict; organizing participative expertise. The outputs of these situations are influenced by an identical factor: the paradoxical importance of misunderstanding, which relies on the weak implementation of the strong equipment, patiently elaborated. The first case is examined with a limited approach of this general perspective: experts in medicine and dentistry who try to rationalize their colleagues’ practices via guidelines, may be considered as specimen of the classical exercise; members of a symphonic orchestra who cooperate with pupils in specific projects with the help of professors and animators, may portray the aim for participative situations. These situations appear to be open to mutual evolutions.
description: Cambio. Rivista sulle Trasformazioni Sociali, Vol. 4 No. 7 (2014)
High-resolution 3D phase imaging using a partitioned detection aperture: a wave-optic analysis
Creators: name: Barankov, Roman
name: Baritaux, Jean-Charles
name: Mertz, Jerome
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Quantitative phase imaging has become a topic of considerable interest in the microscopy community. We have recently described one such technique based on the use of a partitioned detection aperture, which can be operated in a single shot with an extended source [Opt. Lett. 37, 4062 (2012)]. We follow up on this work by providing a rigorous theory of our technique using paraxial wave optics, where we derive fully three-dimensional spread functions for both phase and intensity. Using these functions we discuss methods of phase reconstruction for in- and out-of-focus samples, insensitive to weak attenuations of light. Our approach provides a strategy for detection-limited lateral resolution with an extended depth of field, and is applicable to imaging smooth and rough samples.
description: 12 pages
Intracellular Trafficking Network of Protein Nanocapsules: Endocytosis, Exocytosis and Autophagy
Creators: name: Tao, Wei
name: Liang, Xin
name: Zhu, Xianbing
name: Zhang, Xudong
name: Mei, Lin
name: Liu, Gan
name: Zhang, Jinxie
name: Chang, Danfeng
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The inner membrane vesicle system is a complex transport system that includes endocytosis, exocytosis and autophagy. However, the details of the intracellular trafficking pathway of nanoparticles in cells have been poorly investigated. Here, we investigate in detail the intracellular trafficking pathway of protein nanocapsules using more than 30 Rab proteins as markers of multiple trafficking vesicles in endocytosis, exocytosis and autophagy. We observed that FITC-labeled protein nanoparticles were internalized by the cells mainly through Arf6-dependent endocytosis and Rab34-mediated micropinocytosis. In addition to this classic pathway: early endosome (EEs)/late endosome (LEs) to lysosome, we identified two novel transport pathways: micropinocytosis (Rab34 positive)-LEs (Rab7 positive)-lysosome pathway and EEs-liposome (Rab18 positive)-lysosome pathway. Moreover, the cells use slow endocytosis recycling pathway (Rab11 and Rab35 positive vesicles) and GLUT4 exocytosis vesicles (Rab8 and Rab10 positive) transport the protein nanocapsules out of the cells. In addition, protein nanoparticles are observed in autophagosomes, which receive protein nanocapsules through multiple endocytosis vesicles. Using autophagy inhibitor to block these transport pathways could prevent the degradation of nanoparticles through lysosomes. Using Rab proteins as vesicle markers to investigation the detail intracellular trafficking of the protein nanocapsules, will provide new targets to interfere the cellular behaver of the nanoparticles, and improve the therapeutic effect of nanomedicine.
Senecio apensis Cabrera
Creators: name: Chocarro, María Del Carmen Peña
name: Egea, Juana De
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Asterales
Asteraceae
Senecio
Senecio apensis

description: Senecio apensis Cabrera
Distribution: Brazil, Paraguay.
Source: Teles 2015.
description: Published as part of Chocarro, María Del Carmen Peña & Egea, Juana De, 2018, Checklist of the endemic vascular plants of Paraguay, pp. 448-450 in Phytotaxa 384 (1) on pages 448-450, DOI: 10.11646/phytotaxa.384.1.1, http://zenodo.org/record/13725946
X-Ray Induced Photodynamic Therapy: A Combination of Radiotherapy and Photodynamic Therapy
Creators: name: Wang, Andrew
name: Hao, Zhonglin
name: Li, Zibo
name: Wang, Geoffrey D.
name: Wang, Lianchun
name: Cox, Phillip B.
name: Xie, Jin
name: Nguyen, Ha T.
name: Nagata, Koichi
name: Chen, Hongmin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Conventional photodynamic therapy (PDT)'s clinical application is limited by depth of penetration by light. To address the issue, we have recently developed X-ray induced photodynamic therapy (X-PDT) which utilizes X-ray as an energy source to activate a PDT process. In addition to breaking the shallow tissue penetration dogma, our studies found more efficient tumor cell killing with X-PDT than with radiotherapy (RT) alone. The mechanisms behind the cytotoxicity, however, have not been elucidated. In the present study, we investigate the mechanisms of action of X-PDT on cancer cells. Our results demonstrate that X-PDT is more than just a PDT derivative but is essentially a PDT and RT combination. The two modalities target different cellular components (cell membrane and DNA, respectively), leading to enhanced therapy effects. As a result, X-PDT not only reduces short-term viability of cancer cells but also their clonogenecity in the long-run. From this perspective, X-PDT can also be viewed as a unique radiosensitizing method, and as such it affords clear advantages over RT in tumor therapy, especially for radioresistant cells. This is demonstrated not only in vitro but also in vivo with H1299 tumors that were either subcutaneously inoculated or implanted into the lung of mice. These findings and advances are of great importance to the developments of X-PDT as a novel treatment modality against cancer.
Architects and Consultants Between Formal Regulation and Organised Professionalism
Creators: name: Cucca, Roberta
name: Maestripieri, Lara
Publisher: name: Cambio. Rivista sulle Trasformazioni Sociali
Year: 2016

description: The Italian system of professions is characterized by strong disparities between professionals recognized by the state and non-regulated professions, dividing professionals in terms of protection from market and personal risks. As a consequence, the absence/presence of public regulation is not neutral, but has a direct impact on three factors: education and training, acknowledgement, and welfare integration.This article address this issue explaining the divergences between self-employed representatives of two professions (architects and management consultants), considered as idealtypical examples of those disparities. The investigation has confirmed strong cleavages in terms of education and welfare system access, but not in terms of acknowledgement, that still represents an issue for both the professionals considered. Furthermore, our analysis demonstrates that this fragility is partially balanced by a growing interest in self-organization, which acts as a convergent strategy for both regulated and non-regulated professionals in order to deal with increasing instability in the market and social vulnerability.
description: Cambio. Rivista sulle Trasformazioni Sociali, Vol. 4 No. 7 (2014)
Colistin and tylosin enhances disaccharidase activities, and improves morphology and permeability of the intestine of broilers
Creators: name: Hung, C. C.
name: Chen, C. Y.
name: Chen, B. J.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified

description: 1. The present study focused on the potential effects of antibiotics on intestinal digestion and integrity in broilers in terms of disaccharidase activity, electrophysiological properties and morphology. 2. One-day-old Arbour Acres birds were randomly allocated to one of four treatment groups for 42 days; control, colistin (20 mg/kg), tylosin (55 mg/kg) or chlortetracycline (CTC, 55 mg/kg) groups. Colistin and tylosin supplementation, but not CTC supplementation, caused an increase in body weight gain. 3. Colistin and tylosin elevated the activities of maltase and sucrase in the mucosa of the jejunum on d 42. Age caused a gradual decrease in the short-circuit current (Isc) and conductance (Gt) of the ileum, as a measure of permeability. The Isc and Gt of the ileum were higher in the colistin-supplemented broilers than in the control birds on d 42. Tylosin- and CTC-supplemented birds displayed Isc and Gt values similar to those of the control birds. 4. Colistin supplementation increased the villus area in the jejunum and thinned the muscularis mucosae in the ileum compared with the control group. Tylosin supplementation decreased the thickness of the muscularis mucosae and the depth of crypt in the jejunum. CTC thickened the muscularis mucosae in the jejunum and ileum. 5. Colistin and tylosin exhibited a beneficial effect on intestinal digestion and integrity by enhancing disaccharidase activities and improving gut morphology and permeability.
Extended Maximum Likelihood Halo-independent Analysis of Dark Matter Direct Detection Data
Creators: name: Gelmini, Graciela B.
name: Georgescu, Andreea
name: Gondolo, Paolo
name: Huh, Ji-Haeng
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We extend and correct a recently proposed maximum-likelihood halo-independent method to analyze unbinned direct dark matter detection data. Instead of the recoil energy as independent variable we use the minimum speed a dark matter particle must have to impart a given recoil energy to a nucleus. This has the advantage of allowing us to apply the method to any type of target composition and interaction, e.g. with general momentum and velocity dependence, and with elastic or inelastic scattering. We prove the method and provide a rigorous statistical interpretation of the results. As first applications, we find that for dark matter particles with elastic spin-independent interactions and neutron to proton coupling ratio $f_n/f_p=-0.7$, the WIMP interpretation of the signal observed by CDMS-II-Si is compatible with the constraints imposed by all other experiments with null results. We also find a similar compatibility for exothermic inelastic spin-independent interactions with $f_n/f_p=-0.8$.
description: 26 pages and 15 figures. Some additional explanations added to the text in v3 with respect to v2
title: Questions of Chineseness: A study of China Wind Pop Music and the Post-1990s Generation in the PRC, Hong Kong, Taiwan, and the UK
Creators: name: LIN, Chen-Yu
Publisher: name: University of Liverpool Repository
Year: 2018

description: This thesis examines how ‘Chineseness’ is constructed in China Wind pop music, and how this practice is perceived by a post-1990s audience across Hong Kong, Taiwan, China and the United Kingdom. It will also investigate how China Wind pop music is presented and performed on various stages, such as the music reality TV show The Voice of China. Three main research methods are employed in the thesis: ethnography on music audiences and music industry workers; analysis of songs; and the production and screening of an ethnographic documentary. China Wind music has been popular since 2000, and was first popularised by Taiwanese Mandopop singers, gradually developing into a specific ‘sound’ distinguishable from other pop songs. Traditional Chinese music elements are employed to create a historically ‘authentic’ sonic product, while the lyrical content often involves praising traditional culture or the presentation of a sense of ‘Chinese pride’ in China Wind songs. This thesis focuses on two iconic songs, Wang Leehom’s ‘Heroes of the Earth’ (2005) and Jay Chou’s ‘Blue and White Porcelain’ (2007) to investigate the musical and textual devices employed, as well as their visual representation in music videos. Through four case studies in Hong Kong, Taiwan, China and the UK, this thesis suggests that for different individuals and in various contexts, the construction and perception of Chineseness in popular music requires a multidimensional understanding since Chineseness can function like a chameleon-like resource for identity construction. The production and consumption of China Wind pop music is also an arena for numerous forms of nationalistic sentiment and aspiration, including official and popular nationalism. Chineseness in China Wind pop music is de-centred in its production location and can vary in its place of consumption. However, it may become increasingly re-centred as the growth of the PRC market enforces a particular presentation of Chinese culture. Uncovering micro-histories of those audience and industry workers engaged with China Wind pop music can help to conceptualise, challenge, deconstruct, and perhaps subvert the notion of Chineseness as a singular and unified conception.
The deterministic limit of the Moran model: a uniform central limit theorem
Creators: name: Cordero, Fernando
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: Primary 92D25, 60F05, Secondary 60J27, 60J28

description: We consider a Moran model with two allelic types, mutation and selection. In this work, we study the behaviour of the proportion of fit individuals when the size of the population tends to infinity, without any rescaling of parameters or time. We first prove that the latter converges, uniformly in compacts in probability, to the solution of an ordinary differential equation, which is explicitly solved. Next, we study the stability properties of its equilibrium points. Moreover, we show that the fluctuations of the proportion of fit individuals, after a proper normalization, satisfy a uniform central limit theorem in $[0,\infty)$. As a consequence, we deduce the convergence of the corresponding stationary distributions.
3-D Ultrasound Localization Microscopy for Identifying Microvascular Morphology Features of Tumor Angiogenesis at a Resolution Beyond the Diffraction Limit of Conventional Ultrasound
Creators: name: Pinton, Gianmarco
name: Espíndola, David
name: Shelton, Sarah E.
name: Dayton, Paul A.
name: Rojas, Juan D.
name: Lin, Fanglue
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Angiogenesis has been known as a hallmark of solid tumor cancers for decades, yet ultrasound has been limited in its ability to detect the microvascular changes associated with malignancy. Here, we demonstrate the potential of 'ultrasound localization microscopy' applied volumetrically in combination with quantitative analysis of microvascular morphology, as an approach to overcome this limitation. This pilot study demonstrates our ability to image complex microvascular patterns associated with tumor angiogenesis in-vivo at a resolution of tens of microns - substantially better than the diffraction limit of traditional clinical ultrasound, yet using an 8 MHz clinical ultrasound probe. Furthermore, it is observed that data from healthy and tumor-bearing tissue exhibit significant differences in microvascular pattern and density. Results suggests that with continued development of these novel technologies, ultrasound has the potential to detect biomarkers of cancer based on the microvascular 'fingerprint' of malignant angiogenesis rather than through imaging of blood flow dynamics or the tumor mass itself.
La professione medica nella sanità riformata: alcune categorie concettuali per leggere il mutamento
Creators: name: Sofritti, Federico
Publisher: name: Cambio. Rivista sulle Trasformazioni Sociali
Year: 2016

description: Healthcare has changed a lot during the last decades of the Twentieth century within Western societies: reforms have been implemented to face the increasing challenges of health systems in a context of crisis of the welfare state’s bedrocks. The most important issue of these reforms is the introduction of New Public Management techniques and quasi-market’s principles in public work organizations. This paper is aimed to give some sociological issues conceptualized to read the change involving medical profession within reformed healthcare systems. It focuses on the social context where a need to reform healthcare emerges and it proposes some concepts to interpret the change: managerialism, consumerism and professionalism as logics of work organization, professionalism as occupational and organizational value, reformed healthcare as intersection of two different institutional logics: medical professionalism and business-like healthcare. Afterwards, it is proposed a literature review dealing with professionals/organization relation and researches about doctors’ strategic reactions to marketization process. These studies demonstrate that a reframe of medical profession within health organizations is ongoing, instead of a conflict resulting in a zero sum game between professions and organizations.
description: Cambio. Rivista sulle Trasformazioni Sociali, Vol. 4 No. 7 (2014)
Bounds on Variance for Unimodal Distributions
Creators: name: Chung, Hye Won
name: Sadler, Brian M.
name: Hero, Alfred O.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: We show a direct relationship between the variance and the differential entropy for subclasses of symmetric and asymmetric unimodal distributions by providing an upper bound on variance in terms of entropy power. Combining this bound with the well-known entropy power lower bound on variance, we prove that the variance of the appropriate subclasses of unimodal distributions can be bounded below and above by the scaled entropy power. As differential entropy decreases, the variance is sandwiched between two exponentially decreasing functions in the differential entropy. This establishes that for the subclasses of unimodal distributions, the differential entropy can be used as a surrogate for concentration of the distribution.
description: 19 pages, 3 figures, To appear in IEEE Transactions on Information Theory
La professione ostetrica: mutamenti e nuove prospettive
Creators: name: Spina, Elena
Publisher: name: Cambio. Rivista sulle Trasformazioni Sociali
Year: 2016

description: The paper focuses on the professionalization of Italian midwifery which, in recent years, has been involved in a process of social and professional mobility, together with twenty-one other health occupations. A historical-relational approach has been used. It adheres to Elias’ theoretical perspective according to which professions are considered as the result of the network of relationships that individuals build, therefore influencing their behaviour. Starting from the onset of the XX century, the history of midwifery is reconstructed by dividing it into three distinct phases where periods of professional autonomy alternate with periods of dominationand subordination, thus limiting the acquisition of a professional status. Finally, in the conclusions the paper foreshadows the advent of a fourth phase in which new opportunities as well as new risks may appear for midwives. Only if the latter are able to grasp these opportunities while limiting the risks, can they achieve a higher professional status.
description: Cambio. Rivista sulle Trasformazioni Sociali, Vol. 4 No. 7 (2014)
Dangerous Liaisons. Women, Lawyers and Judges since the 1980s
Creators: name: Tacchi, Francesca
Publisher: name: Cambio. Rivista sulle Trasformazioni Sociali
Year: 2016

description: This paper analyses the evolution of gender roles among lawyers and magistrates in Italy from the 1980s to the present, with a special emphasis on the last 20 years. Within a brief analysis of the various stages of the progressive and very slow women’s empowerment in this area, I discuss the question of the “quality” of female presence, which improved as a result of the new legislation on legal professions (2012), but was also hindered by the economic crisis. The legislation on equal opportunity, unevenly implemented since the early 1990s, reveals that the quantitative data – on female law graduates, on female applicants for judiciary positions, on their presence/absence in local bar associations, on their presence in senior positions in various associations such as the CSM, the CNF, and so on – need to be carefully investigated.The strong female presence among lawyers and judges, which in the future should lead to a female majority, and the very limited number of women at the top levels, suggest that the “glass ceiling” is still relevant in the law professions.
description: Cambio. Rivista sulle Trasformazioni Sociali, Vol. 4 No. 7 (2014)