cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Advanced Computer Technologies for Integrated Agro-Hydrologic Systems Modeling: Coupled Crop and Hydrologic Models for Agricultural Intensification Impacts Assessment
Creators: name: SIAD, S.M.
Publisher: name: unknown
Year: 2023
Subjects: subject: Hydrology
subject: Agronomy
subject: Remote sensing
subject: Modeling

description: Coupling hydrologic and crop models is increasingly becoming an important task when addressing agro-hydrologic systems studies. Either for resources conservation or cropping systems improvement, the complex interactions between hydrologic regime and crop management components requires an integrative approach in order to be fully understood. Nevertheless, the literature offers limited resources on models' coupling that targets environmental scientists. Indeed, major of guides are are destined primarily for computer specialists and make them hard to encompass and apply. To address this gap, we present an extensive research to crop and hydrologic models coupling that targets earth agro-hydrologic modeling studies in its integrative complexity. The primary focus is to understand the relationship between agricultural intensification and its impacts on hydrologic balance. We provided documentations, classifications, applications and references of the available technologies and trends of development. We applied the results of the investigation by coupling the DREAM hydrologic model with DSSAT crop model. Both models were upgraded either on their code source (DREAM) or operational base (DSSAT) for interoperability and parallelization. The resulting model operates at a grid base and daily step. The model is applied southern Italy to analyze the effect of fertilizer application on runoff generation between 2000 and 2013. The results of the study show a significant impacts of nitrogen application on water yield. Indeed, nearly 71.5 thousand cubic-meter of rain water for every kilogram of nitrogen and per hectare is lost as a reduction of runoff coefficient. Furthermore, a significant correlation between the nitrogen applications amount and runoff is found at a yearly basis with Pearson's coefficient of 0.93.
DS_10.1177_0022034520969129 – Supplemental material for Association of Education and Depressive Symptoms with Tooth Loss
Creators: name: S. Fukuhara
name: K. Asai
name: A. Kakeno
name: C. Umebachi
name: S. Yamanaka
name: T. Watanabe
name: T. Yamazaki
name: K. Nakao
name: K. Setoh
name: T. Kawaguchi
name: S. Morita
name: T. Nakayama
name: F. Matsuda
name: K. Bessho
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine
subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, DS_10.1177_0022034520969129 for Association of Education and Depressive Symptoms with Tooth Loss by S. Fukuhara, K. Asai, A. Kakeno, C. Umebachi, S. Yamanaka, T. Watanabe, T. Yamazaki, K. Nakao, K. Setoh, T. Kawaguchi, S. Morita, T. Nakayama, F. Matsuda, K. Bessho, Yasuharu Tabara, Takahisa Kawaguchi, Kazuya Setoh, Yoshimitsu Takahashi, Shinji Kosugi, Takeo Nakayama and Fumihiko Matsuda in Journal of Dental Research
DS_10.1177_0022034520969109 – Supplemental material for Med23 Regulates Sox9 Expression during Craniofacial Development
Creators: name: S. Dash
name: S. Bhatt
name: K.T. Falcon
name: L.L. Sandell
name: P.A. Trainor
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine
subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, DS_10.1177_0022034520969109 for Med23 Regulates Sox9 Expression during Craniofacial Development by S. Dash, S. Bhatt, K. T. Falcon, L.L. Sandell and P.A. Trainor in Journal of Dental Research
Clinical Outcome of Immunosuppressive Therapy in Autoimmune Retinopathy
Creators: name: Song, Seok Hyeon
name: Kim, Min Seok
name: Bae, Seok Hyun
name: Kwak, Jay Jiyong
name: Kim, Yong Jun
name: Kang, Hyun Goo
name: Jeong, Areum
name: Sagong, Min
name: Lee, Christopher Seungkyu
name: Woo, Se Joon
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health
subject: Hematology

description: To evaluate the long-term outcomes of immunosuppressive therapy in patients with autoimmune retinopathy (AIR) and assess differences based on anti-retinal antibody (ARA) profiles. A retrospective multicenter observational study was conducted on 26 AIR patients who received immunosuppressive therapy for at least six months. Clinical information, ophthalmic examinations, and profiles of detected ARAs were collected between March 2011 and November 2023. Comparisons of ophthalmic examination results were performed pre- and post-immunosuppressive therapy. Association and logistic regression analyses were conducted to determine the relationship between ARA profiles and functional and anatomical outcomes. The mean duration of immunosuppressive therapy was 25.3   ±   30.4 months. Among 52 eyes (26 patients), 61% (32 eyes) exhibited worsening best-corrected visual acuity (BCVA), while 10% (5 eyes) showed improvement. The mean BCVA declined significantly from 0.67 ± 0.77 to 1.07 ± 1.02 logMAR (p < 0.001). Optical coherence tomography (OCT) revealed worsening in 35% (18 eyes), improvement in 4% (2 eyes), and no change in 61% (32 eyes). No improvement was observed in the amplitude of any electroretinogram component. Visual field tests indicated worsening in 66% (19/29 eyes). Notably, patients with recoverin antibodies had a higher risk of visual impairment. Multivariable logistic regression analysis revealed no significant associations between the number of ARAs and BCVA or OCT worsening. Despite prolonged immunosuppressive therapy, patients with AIR experienced poor functional and anatomical outcomes. The presence of recoverin antibodies was associated with a higher risk of visual impairment, while the number of ARAs did not significantly correlate with BCVA or OCT worsening.
Advanced Computer Technologies for Integrated Agro-Hydrologic Systems Modeling: Coupled Crop and Hydrologic Models for Agricultural Intensification Impacts Assessment
Creators: name: SIAD, S.M.
Publisher: name: unknown
Year: 2023
Subjects: subject: Agronomy
subject: Hydrology
subject: Modeling

description: Coupling hydrologic and crop models is increasingly becoming an important task when addressing agro-hydrologic systems studies. Either for resources conservation or cropping systems improvement, the complex interactions between hydrologic regime and crop management components requires an integrative approach in order to be fully understood. Nevertheless, the literature offers limited resources on models' coupling that targets environmental scientists. Indeed, major of guides are are destined primarily for computer specialists and make them hard to encompass and apply. To address this gap, we present an extensive research to crop and hydrologic models coupling that targets earth agro-hydrologic modeling studies in its integrative complexity. The primary focus is to understand the relationship between agricultural intensification and its impacts on hydrologic balance. We provided documentations, classifications, applications and references of the available technologies and trends of development. We applied the results of the investigation by coupling the DREAM hydrologic model with DSSAT crop model. Both models were upgraded either on their code source (DREAM) or operational base (DSSAT) for interoperability and parallelization. The resulting model operates at a grid base and daily step. The model is applied southern Italy to analyze the effect of fertilizer application on runoff generation between 2000 and 2013. The results of the study show a significant impacts of nitrogen application on water yield. Indeed, nearly 71.5 thousand cubic-meter of rain water for every kilogram of nitrogen and per hectare is lost as a reduction of runoff coefficient. Furthermore, a significant correlation between the nitrogen applications amount and runoff is found at a yearly basis with Pearson's coefficient of 0.93.
A Framework for Clinicians to Improve the Decision-Making Process in Return to Sport
Creators: name: Yung, Kate K
name: Ardern, Clare
name: Serpiello, Fabio R
name: Robertson, Sam
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 3202
subject: Clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4207
subject: Sports science and exercise

description: Return-to-sport (RTS) decisions are critical to clinical sports medicine and are often characterised by uncertainties, such as re-injury risk, time pressure induced by competition schedule and social stress from coaches, families and supporters. RTS decisions have implications not only for the health and performance of an athlete, but also the sports organisation. RTS decision-making is a complex process, which relies on evaluating multiple biopsychosocial factors, and is influenced by contextual factors. In this narrative review, we outline how RTS decision-making of clinicians could be evaluated from a decision analysis perspective. To begin with, the RTS decision could be explained as a sequence of steps, with a decision basis as the core component. We first elucidate the methodological considerations in gathering information from RTS tests. Second, we identify how decision-making frameworks have evolved and adapt decision-making theories to the RTS context. Third, we discuss the preferences and perspectives of the athlete, performance coach and manager. We conclude by proposing a framework for clinicians to improve the quality of RTS decisions and make recommendations for daily practice and research.
DS_10.1177_0363546520969205 – Supplemental material for Foot Core Training to Prevent Running-Related Injuries: A Survival Analysis of a Single-Blind, Randomized Controlled Trial
Creators: name: Taddei, Ulisses T.
name: Matias, Alessandra B.
name: Duarte, Marcos
name: Sacco, Isabel C.N.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences
subject: 110323 Surgery

description: Supplemental material, DS_10.1177_0363546520969205 for Foot Core Training to Prevent Running-Related Injuries: A Survival Analysis of a Single-Blind, Randomized Controlled Trial by Ulisses T. Taddei, Alessandra B. Matias, Marcos Duarte and Isabel C.N. Sacco in The American Journal of Sports Medicine
title: External shocks, internal shots : the geography of civil conflicts
Creators: name: Berman, Nicolas
name: Couttenier, Mathieu
Publisher: name: Graduate Institute of International and Development Studies
publisherIdentifier: https://ror.org/007ygn379
publisherIdentifierScheme: ROR
Year: 2012

description: Graduate Institute of International and Development Studies Working Paper ; no. 13/2012
Vape_Policy_Review_online_sup_Supplementary_Table_1_Aug_2020 – Supplemental material for Local and State Policy Action Taken in the United States to Address the Emergence of E-Cigarettes and Vaping: A Scoping Review of Literature
Creators: name: O’Connell, Madison
name: Kephart, Lindsay
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: Sociology
subject: FOS: Sociology

description: Supplemental material, Vape_Policy_Review_online_sup_Supplementary_Table_1_Aug_2020 for Local and State Policy Action Taken in the United States to Address the Emergence of E-Cigarettes and Vaping: A Scoping Review of Literature by Madison O’Connell and Lindsay Kephart in Health Promotion Practice
Common Practice Patterns in the Diagnosis and Management of Acute Retinal Necrosis: A Survey Study of Uveitis Specialists
Creators: name: Ray, Isabel K.
name: Sobrin, Lucia
name: Moorthy, Ramana
name: Yeh, Steven
name: Thorne, Jennifer E.
name: Shantha, Jessica G.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Ecology
subject: Science Policy
subject: Plant Biology

description: Due to lack of large randomized clinical trials to determine best practices in treating acute retinal necrosis (ARN), there is not a clear consensus amongst ophthalmologists on how to best manage this potentially blinding condition. The aim of this study is to survey common practice patterns and analyze the factors that affect ophthalmologists’ management of ARN. An anonymous survey was distributed to uveitis and retina specialists who are members of the American Uveitis Society (AUS) via email to query practice patterns regarding ARN. The survey included 22 questions with an additional 10 questions based on response. Survey question topics included demographic information, diagnostic testing, antiviral therapy, corticosteroids, and surgical procedures. 67 surveys were included for analysis. Most respondents (87%) always or frequently obtain intraocular aqueous fluid for diagnostic PCR testing. The majority of respondents would administer intravitreal antiviral injections to a unilateral immunocompetent ARN patient (67%), but would be even more likely to do so for a bilateral immunosuppressed ARN patient (87%). Respondents tend to treat ARN with systemic rather than local corticosteroids, with the majority (63%) of respondents initiating corticosteroid treatment 48 hours after treatment. Most respondents (79%) never perform a vitrectomy to manage ARN unless the patient has a retinal detachment or tear. The majority (63%) rarely or never perform prophylactic laser barricade, but may consider laser treatment if there is extensive retinal involvement. Current practice patterns for diagnosis and management of ARN among AUS members generally align with the suggested practices outlined by the American Academy of Ophthalmology.
Development of molecular detection methods of Bovicola ovis from sheep fleece
Creators: name: Tran, Lily
name: Rawlin, Grant
name: Beddoe, Travis
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 300399
subject: Animal production not elsewhere classified

description: The sheep body louse (Bovicola ovis) commonly referred to as sheep lice are small chewing ectoparasites of sheep. Infection results in significant economic costs to the Australian sheep industry due to reduced wool quality caused by chronic itching from sheep rubbing and biting fleece. Treatment relies on use of insecticides; however, resistance has developed against pyrethroid and other insect growth regulator lousicides. There is urgent need to develop cost-effective lice management to reduce the use of insecticides, with the application of insecticidal treatments only applied when an infestation is detected. However, the current detection method relies on fleece parting for detection of B. ovis which is highly dependent on the skill of the inspector, the number of sheep examined, and the prevalence and severity of the infestation. To improve B. ovis detection, a highly sensitive (5 × 10−8 ng/μL) and specific multiplex quantitative PCR which simultaneously detects sheep lice and sheep DNA was developed. In addition, a B. ovis loop-mediated isothermal amplification (LAMP) assay was developed for field use. The B. ovis LAMP (Bov-LAMP) assay was optimized to reliably detect B. ovis from wool samples down to 5 × 10−6 ng/μL, with time to positive (Tp) < 10 min. Both assays demonstrate high sensitivity and specificity, enabling rapid identification of B. ovis DNA from sheep fleece samples and have the capacity to be used for ongoing management and surveillance of B. ovis in Australian sheep flocks.
Norepinephrine Attenuates Benzalkonium Chloride-Induced Dry Eye Disease by Regulating the PINK1/Parkin Mitophagy Pathway
Creators: name: Zhao, Han
name: Wang, Wushuang
name: Yang, Yun
name: Feng, Changming
name: Lin, Tong
name: Gong, Lan
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Increased reactive oxygen species (ROS) are involved in the pathological process of dry eye disease. Our previous results suggested that norepinephrine (NE) has a protective effect on dry eye. This study explored the potential therapeutic role and underlying mechanisms of NE in benzalkonium chloride (BAC)-induced dry eye disease. BAC-pretreated human corneal epithelial cells (HCEpiC) were cultured with various concentrations of NE. A BAC-induced dry eye mice model was established to explore the role of NE. Alterations in mice corneal tissues, ROS levels, mitochondrial function, and mitophagy levels were analyzed. In vitro, our results revealed that BAC-exposed HCEpiC led to mitochondrial malfunction, which involved excessive ROS production, decreased mitochondrial membrane potential (MMP), and promoted mitochondrial fragmentation through increased DRP1 and fission protein 1 (Fis1) expression and reduced mitofusin 2 (Mfn2) expression. Moreover, topical BAC application induced excessive mitophagy. These effects were reversed by NE. Additionally, the increased expression of LC3B, SQSTM1/p62, PINK1, and Parkin, which control mitophagy, in BAC-exposed HCEpiC was suppressed by NE. In BAC-induced C57BL/6J mice, NE resulted in lower fluorescein staining scores, decreased TUNEL-positive cells, and decreased mitochondrial fragmentation. In conclusion, our findings showed that NE therapy prevented HCEpiC following BAC application by regulating mitochondrial quality control, which is controlled by PINK1/Parkin-dependent mitophagy. Our research suggests a potential targeted treatment for dry eye disease.
Supplemental Material, JIM.19.0150.R4_Web_Appendix_PDF - A Country-of-Origin Perspective on Climate Change Actions: Evidence from France, Morocco, and the United States
Creators: name: Schill, Marie
name: Godefroit-Winkel, Delphine
name: Hughes, Mine Üçok
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 150402 Hospitality Management
subject: FOS: Economics and business

description: Supplemental Material, JIM.19.0150.R4_Web_Appendix_PDF for A Country-of-Origin Perspective on Climate Change Actions: Evidence from France, Morocco, and the United States by Marie Schill, Delphine Godefroit-Winkel and Mine Üçok Hughes in Journal of International Marketing
Additional file 1 of Correlation between tissue Doppler-derived left ventricular systolic velocity (S’) and left ventricle ejection fraction in sepsis and septic shock: a retrospective cohort study
Creators: name: Chawla, Sanchit
name: Sato, Ryota
name: Duggal, Abhijit
name: Alwakeel, Mahmoud
name: Hasegawa, Daisuke
name: Alayan, Dina
name: Collier, Patrick
name: Sanfilippo, Filippo
name: Lanspa, Michael
name: Dugar, Siddharth
Publisher: name: figshare
Year: 2024
Subjects: subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Computational Biology

description: Additional file 1: Table S1. Pearson correlation between LVEF % and Mitral S’with sub group analyis based on gender, BMI, heart failure and various severity of sepsis. Table S2. Assessing interrater reliability for Mitral S’ measurements. Table S3. Multivariable logistic regression model for in-hospital mortality in patients with sepsis and septic shock. Figure S1. PRISMA flow diagram representing the final study population. Figure S2. Pearson Correlation between Average Mitral S’ and LVEF among subgroup analysis. Figure S3. Pearson correlation between average Mitral S’ and average E/e’. Figure S4. Pearson Correlation between Average Mitral S’ and 24-h Max Norepinephrine Equivalent dose
Designing and testing an ethnic-ancestry question for Australian blood donors: Acceptability, feasibility, and understanding
Creators: name: Gahan, Luke
name: Gemelli, Carley N
name: Kruse, Sarah P
name: Davison, Tanya E
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 420699
subject: Public health not elsewhere classified

description: Objectives: We aimed to evaluate the acceptability, feasibility, and understanding of a donor ethnic-ancestry question with Australian blood donors. Background: Ethnic-ancestry assists blood collection agencies to meet the demand for rare blood-types. However, there is no standard ethnicity question used by health/blood services around the world and we do not know how blood donors in Australia will respond to being asked for this information. Methods/Materials: A survey and ethnic-ancestry question was administered to a sample of donors (n = 506) to evaluate their views on being asked for their ethnic-ancestry, test a comprehensive ethnic-ancestry list, and determine the level of information required by donors. Results: Donors reported being very comfortable providing their ethnic-ancestry and the majority of donors found an ethnic-ancestry option they were happy with (91.3%). Overall donors reported a high level of understanding of why ethnic-ancestry was important to blood donation. However, when provided more information on why ethnic-ancestry is required, donors reported increased understanding. Conclusion: The findings from this study demonstrated that it is acceptable and feasible to introduce a comprehensive ethnic-ancestry question for Australian blood donors. We also found that a greater understanding is achieved when a more comprehensive explanation for inclusion of the question is provided.
Small caliber arterial prosthesis: prototype and pre-industrialization
Creators: name: CALVO CATOIRA, Marta
Publisher: name: Universit� degli Studi del Piemonte Orientale Amedeo Avogadro
Year: 2020

description: Cardiovascular diseases represent the leading cause of death in developed countries. Modern surgical methods show poor efficiency in the substitution of small-diameter arteries (< 6 mm). Due to the mismatch in mechanical properties between the native artery and the substitute, the behavior of the vessel wall remains a major cause of inefficient substitutions an unsolved complication in surgery since 1970. The purpose of this work was to obtain polylysine-enriched vascular substitutes, derived from decellularized porcine femoral and carotid arteries. Polylysine was selected as a matrix cross-linker, increasing the mechanical resistance of the scaffold with respect to decellularized vessels, without altering the native biocompatibility and haemocompatibility properties.
The biological characterization showed excellent biological performances, while mechanical tests displayed that the Young?s modulus of the polylysine-enriched matrix was comparable to that of the native vessel. Concerning haemocompatibility, the performed analyses show that polylysine-enriched matrices increase coagulation time, with respect to commercial Dacron� vascular substitutes. Based on these findings, polylysine-enriched decellularized vessels resulted in a promising approach for vascular substitution.
In order to consider the industrial phase, a business plan (BP) and the preengineering of the production reactor were developed in the present project. Is crucial to consider the scale-up process of the project from the initial stages to increase the chances of its success. In this way, the feasibility study will contemplate the viability of the project from an economic point of view thus, the BP is the most important document of the study. From an engineering point of view, the industrial production reactor is the heart of the plant, so designing it from the outset will allow considering costs and performing the necessary experiments for its final design.
Systems of Storytelling in Classics and Fan Studies: A Conversation with Stella Fritzell and Hannah Mendro
Creators: name: Fritzell, Stella
name: Mendro, Hannah
Publisher: name: unknown
Year: 2024
Subjects: subject: Fan fiction
subject: Literature
subject: Storytelling
subject: Classical languages--Study and teaching
subject: Classical studies
subject: Popular culture--Study and teaching
subject: Mythology
subject: Culture--Study and teaching
subject: Humanities
subject: FOS: Humanities

description: On Wednesday, March 6, 2024, HASTAC Scholars Stella Fritzell and Hannah Mendro met to discuss some exciting intersections between their work in the fields of Classics and Fan Studies. What arose was a fruitful discussion about engagement in myth and narrative media, questions of narrative potentiality and positionality, and the promise of storytelling and story-interpretation as liberatory acts. Due to the length of Stella and Hannah's discussion, this dialogue was published as a three-part blog series on the HASTAC Humanities, Arts, and Media website. This document contains the full transcript of the dialogue, without the divisions used in the blog series.
Changes in Axial Length in Patients of Acute Retinal Necrosis Undergoing Vitrectomy
Creators: name: Lei, Boya
name: Zhou, Yao
name: Ding, Xinyi
name: Gu, Ruiping
name: Shu, Qinmeng
name: Wang, Min
name: Chang, Qing
name: Xu, Gezhi
name: Zhou, Min
name: Jiang, Rui
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Hematology

description: To observe the changes in the axial length (AL) in patients of acute retinal necrosis (ARN) undergoing vitrectomy and investigate the correlated factors. Retrospective case series. Patients diagnosed as ARN undergoing vitrectomy with silicone oil (SO) tamponade, and with attached retina more than one year after silicone oil removal (SOR) were included. Medical records and AL measured by Zeiss IOLMaster 700 were reviewed before vitrectomy, before SOR, and one year after SOR. Residual retinal index, a parameter reflecting the residual retinal area after vitrectomy was analyzed based on the ultra-wide-field fundus imaging. The AL change (ΔAL) was calculated and clinical factors related to ΔAL were investigated. In total, 45 eyes from 45 patients were included. The AL at pre-vitrectomy and pre-SOR was 23.84 ± 1.45 and 23.53 ± 1.53 mm among all 45 eyes, with a ΔAL of 0.31 ± 0.62 mm (p < 0.001). Among the 22 eyes with AL measured at one year after SOR, the AL at pre-SOR and one-year post-SOR was 23.82 ± 1.60 and 23.16 ± 0.79 mm, with a ΔAL of 0.67 ± 1.58 mm (p < 0.001). After excluding highly myopic eyes, the ΔAL was 0.31 ± 0.59 mm (n = 42, p < 0.001) between pre-vitrectomy and pre-SOR, and 0.22 ± 0.32 mm (n = 20, p = 0.001) between pre-SOR and one-year post-SOR. Multivariable regression analysis revealed the variable that remained independently associated with ΔAL between pre-SOR and one-year post-SOR was the residual retinal index (β = –0.568, p = 0.006). For ARN patients undergoing vitrectomy, AL decreased significantly both post-vitrectomy and post-SOR. The refractive shift should be considered before intraocular lens implantation.
Skeletal muscle cell-specific differences in type 2 diabetes
Creators: name: Frankenberg, Noni
name: Mason, SA
name: Wadley, GD
name: Murphy, Robyn
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3101
subject: Biochemistry and cell biology
classificationCode: 3205
subject: Medical biochemistry and metabolomics
classificationCode: 3211
subject: Oncology and carcinogenesis

description: Major stores of glucose are found as glycogen in skeletal muscle and liver. Skeletal muscle is a heterogenous tissue, with cellular metabolic and contractile distinctions dependent on whether the cell (fibre) is slow-twitch (Type I) or fast-twitch (Type II). We hypothesised that proteins important for glycogen metabolism would be differentially abundant between these diverse fibres. We further hypothesised that the cellular location of these proteins would be different in muscle samples between control (CON) and individuals with type 2 diabetes (T2D). We dissected individual muscle fibre segments from vastus lateralis skeletal muscle biopsy samples from CON and T2D and used cell-type-specific approaches to address muscle heterogeneity. We measured glycogen and glycogen-related proteins by immunoblotting techniques. A lower proportion of Type I fibres was found in muscle in T2D compared with CON. AMPK-β2, glycogen branching enzyme (GBE), glycogen debranching enzyme (GDE), and glycogen phosphorylase (GP) were differentially localized between fibre types and in fibres from CON and T2D individuals. A key novel finding was that the majority of glycogen is loosely bound or cytosolic in location in human skeletal muscle. The proportion of this diffusible pool of glycogen was significantly lower in Type I fibres in T2D compared to CON. A hyperinsulinaemic, euglycaemic clamp in people with type 2 diabetes had no effect on the proportion of diffusible glycogen. We identify cell-type as an important consideration when assessing glycogen metabolism in muscle. Our findings demonstrate varying glucose handling abilities in specific muscle fibre types in type 2 diabetes. A model is presented to provide an overview of the cell-specific differences in glycogen metabolism in type 2 diabetes.
2024 Collaborative Book Review: Interview with Catherine D'Ignazio and Lauren Klein, authors of Data Feminism (2020)
Creators: name: Cole, Abby
name: D'Ignazio, Catherine
name: Fritzell, Stella
name: Khatri, Hamida
name: Klein, Laruen
name: Setayesh, Parisa
Publisher: name: unknown
Year: 2024
Subjects: subject: Journalism
subject: Interviews
subject: Feminism
subject: Open access publishing
subject: Scholarly publishing
subject: Information visualization

description: On May 20, 2024, HASTAC Scholars Abby Cole, Stella Fritzell, Hamida Khatri, and Parisa Setayesh met with Catherine D'Ignazio and Lauren Klein to discuss their 2020 book, Data Feminism, which was also one of the subjects of the 2024 HASTAC Scholars collaborative book review project. The document is a corrected transcript of their conversation, which was originally published as a blog post on the HASTAC Technology, Networks, and Sciences website.
Toxic Orbital Cellulitis and Optic Neuropathy from High-Pressure Diesel Fuel Injury: A Case Report and Literature Review
Creators: name: Rafizadeh, Seyed Mohsen
name: Rajabi, Mohammad Taher
name: Aghajani, Amirhossein
name: Rahmanikhah, Elham
name: Ghochani, Ghazal
name: Seyedi, Seyedeh Zahra
name: Haydar, Ali A.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Space Science
subject: Medicine
subject: Neuroscience
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: High-pressure injuries to the orbit are rare, yet they can cause severe damage due to mechanical destruction and the toxicity of the injected substance. Diesel fuel toxicity can lead to rapid necrosis and inflammation, complicating the prognosis even with prompt medical intervention. A 39-year-old male presented with a right orbital injury from a diesel fuel explosion. Initial symptoms included mild periorbital swelling and a laceration on the upper eyelid. Despite early management with antibiotics and surgical repair, the patient’s condition rapidly deteriorated, developing severe periorbital swelling, pain, and decreased vision. Multiple surgical debridements were performed to remove necrotic tissue and residual diesel fuel. Aggressive treatment with broad-spectrum antibiotics and corticosteroids was administered. Despite the aggressive treatment, the patient’s vision deteriorated to no light perception, indicative of optic neuropathy. Over the following days, the patient showed significant improvement and was eventually discharged with ongoing antibiotic therapy. At a 6-month follow-up, the patient had good cosmetic outcomes despite mild limitations in eye movement. High-pressure orbital injuries, especially those involving toxic substances like diesel fuel, require early and aggressive management. A multidisciplinary approach, including prompt surgical intervention, broad-spectrum antibiotics, and corticosteroids, is essential to improve outcomes and preserve vital structures. Long-term follow-up is crucial to address functional and cosmetic sequelae. Further research is needed to develop evidence-based protocols, especially for toxic orbital cellulitis.
Gli unica inediti del ms. 10077, BNE, Madrid
Creators: name: Torregiani, Violetta
Publisher: name: Universit� degli studi di Trento
Year: 2019

description: Il lavoro ha lo scopo di offrire l?edizione critica e il commento dei testi che il ms. 10077 della Biblioteca Nazionale di Spagna, a Madrid (M), tramanda come unico testimone. Si tratta di 25 componimenti in versi, di diverso metro e diversa struttura, ma tutti di argomento morale e religioso. L?edizione vera e propria � preceduta da un?ampia introduzione suddivisa in cinque sezioni: la prima � dedicata alla descrizione e alla storia del manoscritto; la seconda si concentra sul corpus oggetto di edizione; la terza offre invece un quadro di riferimento storico utile non solo per dare uno sfondo alla produzione del codice ma anche per comprendere eventuali riferimenti presenti nei testi; la quarta sezione � dedicata agli appunti sulla lingua; nella quinta, infine, si trovano esposti i criteri di edizione. All'introduzione seguono i testi. Ogni testo � preceduto da una breve introduzione e seguito da un commento, volto soprattutto a cercare di identificare i possibili riferimenti culturali e le possibili fonti dei testi, nonch� a mettere in evidenza quelle vicinanze utili ad inserire i componimenti in un clima culturale e spirituale, o in una tradizione, specifici. La scelta di allestire l?edizione degli inediti in unica attestazione (status, � necessario ricordarlo, di per s� molto precario) risiede nella convinzione che alcuni di questi testi tramandati dal solo M hanno una qualche probabilit� di essere frutto dell?ambiente in cui M � stato prodotto, cio� la zona orvietana, e di essere rimasti chiusi in quell'ambiente di produzione senza aver trovato poi circolazione altrove. Questi testi possono essere allora molto interessanti per approfondire una realt� culturale ben specifica che acquisisce al suo attivo nuove, preziose, testimonianze.
Red Blood Cell BCL-xL Is Required for Plasmodium falciparum Survival: Insights into Host-Directed Malaria Therapies
Creators: name: Boulet, Coralie
name: Siddiqui, G
name: Gaynor, Taylah
name: Doerig, C
name: Creek, DJ
name: Carvalho, Ana-Teresa
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 310199
subject: Biochemistry and cell biology not elsewhere classified
classificationCode: 320799
subject: Medical microbiology not elsewhere classified

description: The development of antimalarial drug resistance is an ongoing problem threatening progress towards the elimination of malaria, and antimalarial treatments are urgently needed for drug-resistant malaria infections. Host-directed therapies (HDT) represent an attractive strategy for the development of new antimalarials with untapped targets and low propensity for resistance. In addition, drug repurposing in the context of HDT can lead to a substantial decrease in the time and resources required to develop novel antimalarials. Host BCL-xL is a target in anti-cancer therapy and is essential for the development of numerous intracellular pathogens. We hypothesised that red blood cell (RBC) BCL-xL is essential for Plasmodium development and tested this hypothesis using six BCL-xL inhibitors, including one FDA-approved compound. All BCL-xL inhibitors tested impaired proliferation of Plasmodium falciparum 3D7 parasites in vitro at low micromolar or sub-micromolar concentrations. Western blot analysis of infected cell fractions and immunofluorescence microscopy assays revealed that host BCL-xL is relocated from the RBC cytoplasm to the vicinity of the parasite upon infection. Further, immunoprecipitation of BCL-xL coupled with mass spectrometry analysis identified that BCL-xL forms unique molecular complexes with human µ-calpain in uninfected RBCs, and with human SHOC2 in infected RBCs. These results provide interesting perspectives for the development of host-directed antimalarial therapies and drug repurposing efforts.
Additional file 1 of β1 integrin is essential for blood–brain barrier integrity under stable and vascular remodelling conditions; effects differ with age
Creators: name: Halder, Sebok K.
name: Delorme-Walker, Violaine D.
name: Milner, Richard
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Biotechnology
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology

description: Additional file 1: Figure S1 Chronic mild hypoxia (CMH)-induced upregulation of laminin and α6 and α1 integrins is similar in young and aged brains. Figure S2. Vascular localization of the function-blocking β1 integrin antibody in young and aged mice brains under normoxic and hypoxic conditions. Figure S3. The impact of β1 integrin blockade on cerebrovascular leak in young and aged mice under normoxic conditions. Figure S4. The impact of β1 integrin blockade on cerebrovascular leak and remodeling in aged mice after 2 days hypoxia. Figure S5. The impact of β1 integrin blockade on vascular tight junction protein expression. Figure S6. The impact of β1 integrin blockade on vascular VE-cadherin expression.
Intraocular Metastatic Lung Adenocarcinoma Masquerading as an Intermediate Uveitis
Creators: name: Nguyen, Robert D.
name: Livnat, Itamar
name: Krishnan, Vimal
name: Stewart, Jay M.
name: Gonzales, John A.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: To report on the clinical and cytopathological features of metastatic lung adenocarcinoma to the eye masquerading as an intermediate uveitis. Retrospective chart review. A 63-year-old woman with a history of lung adenocarcinoma in remission presented with progressive vision loss and floaters in the right eye. Clinically, her uveitis was classified as a non-granulomatous anterior/intermediate uveitis. Pars plana vitrectomy was performed and cytopathology of the vitreous was unremarkable but directed polymerase chain reaction (PCR) was positive for HSV-1. Despite dual antiviral and antibiotic therapy, her visual acuity and intraocular inflammation progressively worsened prompting repeat vitrectomy with cytopathology revealing metastatic adenocarcinoma. Intraocular metastatic lung adenocarcinoma can masquerade as an intermediate uveitis, presenting significant diagnostic challenges. Early and repeated cytopathological analysis of vitreous samples is crucial when the diagnosis remains uncertain, as it can lead to timely and accurate identification of metastatic carcinoma, thereby improving patient management and outcomes. This case underscores the diagnostic challenges and clinical complexity of distinguishing intraocular metastatic lung adenocarcinoma from intermediate uveitis.
Supplemental Material, Supplement_1 - Can Acupuncture Improve Chronic Spinal Pain? A Systematic Review and Meta-Analysis
Creators: name: Huang, Jin-Feng
name: Zheng, Xuan-Qi
name: Chen, Dong
name: Lin, Jia-Liang
name: Zhou, Wen-Xian
name: Wang, Hui
name: Qin, Zongshi
name: Wu, Ai-Min
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Orthopaedics
subject: Sports Medicine
subject: Surgery

description: Supplemental Material, Supplement_1 for Can Acupuncture Improve Chronic Spinal Pain? A Systematic Review and Meta-Analysis by Jin-Feng Huang, Xuan-Qi Zheng, Dong Chen, Jia-Liang Lin, Wen-Xian Zhou, Hui Wang, Zongshi Qin and Ai-Min Wu in Global Spine Journal
Hepatitis B and pregnancy: understanding the experiences of care among pregnant women and recent mothers in metropolitan Melbourne
Creators: name: Ahad, M
name: Wallace, John
name: Xiao, Y
name: van Gemert, C
name: Bennett, G
name: Darby, J
name: Desmond, P
name: Hall, S
name: Holmes, J
name: Papaluca, T
name: Glasgow, S
name: Thompson, A
name: Hellard, M
name: Doyle, J
name: Howell, J
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 420699
subject: Public health not elsewhere classified

description: Background: Pregnant women are a priority group for hepatitis B testing. Guideline-based care during antenatal and post-partum periods aims to prevent mother-to-child transmission of hepatitis B virus and lower the risk of liver complications in mothers. This qualitative study explored knowledge of hepatitis B and experiences of hepatitis B related care among pregnant women and mothers. Methods: Semi-structured interviews were conducted with thirteen women with hepatitis B who were attending antenatal or post-partum hepatitis B care. The interviews were thematically analysed to assess knowledge and understanding of hepatitis B. Participants were recruited from specialist clinics in metropolitan Melbourne between August 2019 and May 2020. Results: Four major themes were identified from interviews: (1) knowledge and understanding of hepatitis B, (2) treatment pathways, (3) accessing hepatitis B related care, and (4) disclosing status to friends. Most participants displayed an understanding of hepatitis B transmission, including mother to child transmission. The main motivator of post-partum attendance was reassurance gained concerning their child’s health. Sources of hepatitis B information included doctors, online information and family. Participants identified parents and siblings as sources of support and reported an unwillingness to disclose hepatitis B status to friends. Conclusions: Women attending antenatal or post-partum care reported having overall positive experiences, particularly regarding reassurance of their child’s health, but displayed misconceptions around horizontal transmission. Knowledge gained from these results can contribute to the development of targeted models of care for pregnant women and mothers with young children to ensure their successful linkage to care.
Clinical and Imaging Characteristics of Posterior Scleritis in Children
Creators: name: Katzir, Ayala
name: Amer, Radgonde
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Immunology
subject: FOS: Clinical medicine

description: Posterior scleritis (PS) is a rare phenotype of scleritis. Comprehensive epidemiological studies on PS in children are limited. We aimed to report on its clinical and imaging features in one of the largest pediatric series to date. Retrospective review of medical files. Included were 12 children (7 girls, mean±SD age at diagnosis 13.75 ± 3.3 years,18 eyes, mean follow-up ±SD of 46.7 ± 45.9 months). All patients presented with eye pain followed by headache. Papillitis was the most common presenting sign (16 eyes, 88.9%). Seven patients (58%) showed laboratory markers of systemic inflammation. One patient had periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA). In 2 other patients, Behҫet disease and inflammatory bowel disease were diagnosed subsequently. Initial echography showed increased posterior scleral thickness (mean±SD 2.9 ± 0.68 mm) with a significant reduction four ± 2 months later (mean±SD 1.85 ± 0.62 mm). Retinal nerve fiber layer (RNFL) was thickened in all examined eyes (mean±SD 136.2 ± 28.4 µm) at presentation and it significantly decreased with treatment (109.8 ± 8.2 µm two months later). In 5 patients (42%), diagnosing PS was prompted by Brain imaging. PS was part of orbital inflammatory syndrome in 4 patients (33.3%). All patients were treated with systemic steroids and 91% required steroid-sparing agent. Adalimumab was added in 2 patients. A chronic course was observed in 63.6%. Remission was achieved in 4 patients. Mean±SD presenting LogMAR VA was 0.23 ± 0.3 with marked improvement to 0.04 ± 0.07 one month later. Searching for an associated autoinflammatory/autoimmune disease is an important step in patients’ triaging. B-scan ultrasound remains the gold standard test. OCT proved to be of practical importance in delineating the magnitude of RNFL thickness and could serve as a potential imaging biomarker of disease activity.
Additional file 1 of Middle Eastern nurses’ views/experiences of work and well-being with the support measures during past disease outbreaks and COVID-19: a qualitative systematic review
Creators: name: Marair, Sara Ahmed
name: Slater, Nigel
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Cancer

description: Additional file 1.
Supplementary material
Creators: name: Kuryla, Domantas
name: Csanyi, Gabor
name: van Duin, Adri
name: Michaelides, Angelos
Publisher: name: AIP Publishing
Year: 2025
Subjects: classificationCode: 34
subject: Chemical sciences
subject: FOS: Chemical sciences

description: Additional data and figures supporting statements made in the manuscript, in addition to instuctions for running simulations.
Improving access to conservation detection dogs: identifying motivations and understanding satisfaction in volunteer handlers
Creators: name: Rutter, Nicholas
name: Stukas, Arthur
name: Howell, Tiffani
name: Pascoe, Jack H
name: Bennett, Pauleen
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 410401
subject: Conservation and biodiversity
classificationCode: 419999
subject: Other environmental sciences not elsewhere classified
classificationCode: 319999
subject: Other biological sciences not elsewhere classified

description: No description supplied
Author_Response_1_1 – Supplemental material for Current situation of asthma–COPD overlap in Chinese patients older than 40 years with airflow limitation: a multicenter, cross-sectional, non-interventional study
Creators: name: Kang, Jian
name: Zheng, Jinping
name: Cai, Baiqiang
name: Wen, Fuqiang
name: Yao, Wanzhen
name: Zhang, Xiaoju
name: Chen, Yan
name: Wang, Guansong
name: Li, Wen
name: Cao, Jie
Publisher: name: SAGE Journals
Year: 2020
Subjects: Aged Health Care
Pharmacology and Pharmaceutical Sciences not elsewhere classified
Respiratory Diseases

description: Supplemental material, Author_Response_1_1 for Current situation of asthma–COPD overlap in Chinese patients older than 40 years with airflow limitation: a multicenter, cross-sectional, non-interventional study by Jian Kang, Jinping Zheng, Baiqiang Cai, Fuqiang Wen, Wanzhen Yao, Xiaoju Zhang, Yan Chen, Guansong Wang, Wen Li and Jie Cao in Therapeutic Advances in Respiratory Disease