cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Mixed Exocrine-Endocrine Tumors of the Pancreas
Creators: name: Milanetto, Anna Caterina
name: Liço, Valbona
name: Moletta, Lucia
name: Alaggio, Rita
name: Sperti, Cosimo
name: Pedrazzoli, Sergio
name: Pasquali, Claudio
Publisher: name: JOP. Journal of the Pancreas
Year: 2012
Subjects: Meeting Abstracts; Pancreas

description: Context Mixed exocrine-endocrine pancreatic tumors are extremely rare representing only 0.2% of all pancreatic tumors. They are characterized by the association of an exocrine (ductal or acinar) with an endocrine component with positive immunostaining for endocrine markers in >30% of the tumor cells. Mixed pancreatic carcinomas are usually large tumors, located in the head of the pancreas (60%), occurring mostly in middle aged patients. Objective To evaluate clinical presentation, surgical therapy, histological features, outcome and follow up of mixed exocrine/endocrine tumors observed in the last 10 years. Methods We reviewed the clinical records of 6 patients affected by mixed exocrine-endocrine tumors of the pancreas, admitted in our Unit from June 2002 to December 2011. Results Out of six patients enrolled in the study (3 females and 3 males averaging 67.5 years) 2 were asymptomatic, 3 had jaundice, and 1 had hypoglycemia. Five were in the head and 1 in the whole pancreas, with 2 cases of hepatic and peritoneal metastases. The size of the primary tumor ranged 1.4-10.0 cm. Three cases expressed exocrine serum tumor markers (CA 19-9, aFP, CEA, CA 125), and 1 neuroendocrine markers. We performed 2 pancreaticoduodenectomy, 1 bypass surgery for vascular involvement and 1 enucleation. Two cases had only pancreatic/hepatic percutaneous biopsy. Post-operative mortality was nihl and morbidity was 2/4:1 abdominal fluid collection and 1 asymptomatic pseudocyst. Histological features: 2 acinar cell carcinomas with neuroendocrine component, 2 ductal adenocarcinomas with neuroendocrine component, 2 neuroendocrine tumors with a ductal carcinoma component. Mean follow up was 28.8 months (range: 3-114 months; in 5/6 cases with at least 3 months of follow up). In 2/5 cases who had primary tumor resection DFS was 17 and 114 months. In 2/5 cases with peritoneal metastatic disease survival was 3 and 6 months. Conclusion The prognosis of pancreatic tumor with mixed exocrine/endocrine cells is strongly conditioned by the behavior of the exocrine component. In most cases the histological diagnosis is known only postoperatively and the therapeutic approach is not changed by the final diagnosis.
description: JOP. Journal of the Pancreas, Vol 13, N° 5S (2012): September (Suppl.) - p. 548-650
Relations for certain symmetric norms and anti-norms before and after partial trace
Creators: name: Rastegin, Alexey E.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Physics (quant-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: Changes of some unitarily invariant norms and anti-norms under the operation of partial trace are examined. The norms considered form a two-parametric family, including both the Ky Fan and Schatten norms as particular cases. The obtained results concern operators acting on the tensor product of two finite-dimensional Hilbert spaces. For any such operator, we obtain upper bounds on norms of its partial trace in terms of the corresponding dimensionality and norms of this operator. Similar inequalities, but in the opposite direction, are obtained for certain anti-norms of positive matrices. Through the Stinespring representation, the results are put in the context of trace-preserving completely positive maps. We also derive inequalities between the unified entropies of a composite quantum system and one of its subsystems, where traced-out dimensionality is involved as well.
description: 11 pages, no figures. A typo error in Eq. (5.15) is corrected. Minor improvements. J. Stat. Phys. (in press)
Pseudotrochalus Quedenfeldt 1884
Creators: name: Allsopp, Peter G.
name: Schoolmeesters, Paul
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Pseudotrochalus

description: Pseudotrochalus Quedenfeldt, 1884
[79 species].
Type species Trochalus sulcipennis Gerstaecker, 1867, by subsequent designation of Ahrens (2007a).
description: Published as part of Allsopp, Peter G. & Schoolmeesters, Paul, 2024, All genera of the world: Subfamilies Prototroginae, Cretoscarabaeinae, Dynamopodinae, Electrorubesopsinae, Phaenomeridinae, Orphninae, Allidiostomatinae, Aclopinae, Lichniinae, Melolonthinae, Oncerinae, Podolasiinae, Sericinae, Sericoidinae (Animalia: Arthropoda: Insecta: Coleoptera: Scarabaeidae), pp. 104-175 in Megataxa 12 (1) on page 146, DOI: 10.11646/megataxa.12.1.2, http://zenodo.org/record/14984437
Non-Gaussianity and Dynamical Trapping in Locally Activated Random Walks
Creators: name: Bénichou, O.
name: Meunier, N.
name: Redner, S.
name: Voituriez, R.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We propose a minimal model of \emph{locally-activated diffusion}, in which the diffusion coefficient of a one-dimensional Brownian particle is modified in a prescribed way --- either increased or decreased --- upon each crossing of the origin. Such a local mobility decrease arises in the formation of atherosclerotic plaques due to diffusing macrophage cells accumulating lipid particles. We show that spatially localized mobility perturbations have remarkable consequences on diffusion at all scales, such as the emergence of a non-Gaussian multi-peaked probability distribution and a dynamical transition to an absorbing static state. In the context of atherosclerosis, this dynamical transition can be viewed as a minimal mechanism that causes macrophages to aggregate in lipid-enriched regions and thereby to the formation of atherosclerotic plaques.
Fecal Elastase-1 Is Useful in the Detection of Steatorrhea in Patients with Pancreatic Diseases But Not After Pancreatic Resection
Creators: name: Campagnola, Pietro
name: Cristofori, Chiara
name: Amodio, Antonio
name: Agugiaro, Flora
name: Micciolo, Rocco
name: Magro, Alessandra
name: Gabbrielli, Armando
name: Moser, Luisa
name: Massella, Arianna
name: Frulloni, Luca
name: Vantini, Italo
name: Benini, Luigi
Publisher: name: JOP. Journal of the Pancreas
Year: 2012
Subjects: Meeting Abstracts; Pancreas

description: Context The measurement of steatorrhea in pancreatic disorders is complex and has limited diagnostic role. Fecal elastase-1 (FE-1) has been suggested as a simpler alternative to evaluate pancreatic insufficiency, but its diagnostic performance has never been compared with steatorrhea in patients with chronic pancreatitis or after pancreatic resection. Methods. The relationship between steatorrhea and FE-1 was studied in patients with suspected of malabsorption due to chronic pancreatic disorders or pancreatic resection. Analysis of variance (ANOVA) was used for statistical analysis, accepting a P value of 0.05 as limit for significance. Results Eighty-two patients were studied (42 non operated; 40 previously submitted to pancreatic resection). Fat output was pathological in 50, and more severe in operated than non-operated patients (29.2±3.1 vs. 9.9±2.2 g/day, P<0.001). FE-1 was consistent with exocrine impairment in 58 (severe 50, moderate 8), which was significantly more severe in operated patients. The relationship between FE-1 and steatorrhea was described by a power regression model (Figure 1), with a regression line significantly different in operated and non operated patients (P<0.001). A steatorrhea of 7 g (upper limit of reference range) was calculated by this regression when FE-1 was 15 μg/g in non-operated, but as high as 225 μg/g in operated patients. Conclusion FE-1 is useful to identify pancreatic insufficiency. Steatorrhea is anticipated in non operated patients only when FE-1 is below the limit for a confident measurement of our assay. In operated patients, steatorrhea may be present even if FE-1 is only slightly reduced, to confirm a role for non pancreatic factors.
description: JOP. Journal of the Pancreas, Vol 13, N° 5S (2012): September (Suppl.) - p. 548-650
The Vector Valued Quartile Operator
Creators: name: Hytönen, Tuomas P.
name: Lacey, Michael T.
name: Parissis, Ioannis
Publisher: name: arXiv
Year: 2012
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: 42B20, 46E40

description: Certain vector-valued inequalities are shown to hold for a Walsh analog of the bilinear Hilbert transform. These extensions are phrased in terms of a recent notion of quartile type of a UMD (Unconditional Martingale Differences) Banach space X. Every known UMD Banach space has finite quartile type, and it was recently shown that the Walsh analog of Carleson's Theorem holds under a closely related assumption of finite tile type. For a Walsh model of the bilinear Hilbert transform however, the quartile type should be sufficiently close to that of a Hilbert space for our results to hold. A full set of inequalities is quantified in terms of quartile type.
description: 32 pages, 5 figures, incorporates referee's report, to appear in Collect. Math
Diving Deep into the Data: A Review of Deep Learning Approaches and Potential Applications in Foodomics
Creators: name: Class, Lisa-Carina
name: Kuhnen, Gesine
name: Rohn, Sascha
name: Kuballa, Jürgen
Publisher: name: Technische Universität Berlin
Year: 2021
Subjects: subject: 630 Landwirtschaft und verwandte Bereiche
subject: deep learning
subject: machine learning
subject: metabolomics
subject: food authenticity
subject: food fraud
subject: shelf-life
subject: peptide sequencing
subject: mass spectrometry

description: Deep learning is a trending field in bioinformatics; so far, mostly known for image processing and speech recognition, but it also shows promising possibilities for data processing in food analysis, especially, foodomics. Thus, more and more deep learning approaches are used. This review presents an introduction into deep learning in the context of metabolomics and proteomics, focusing on the prediction of shelf-life, food authenticity, and food quality. Apart from the direct food-related applications, this review summarizes deep learning for peptide sequencing and its context to food analysis. The review’s focus further lays on MS (mass spectrometry)-based approaches. As a result of the constant development and improvement of analytical devices, as well as more complex holistic research questions, especially with the diverse and complex matrix food, there is a need for more effective methods for data processing. Deep learning might offer meeting this need and gives prospect to deal with the vast amount and complexity of data.
Gradient-based stopping rules for maximum-likelihood quantum-state tomography
Creators: name: Glancy, Scott
name: Knill, Emanuel
name: Girard, Mark
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: When performing maximum-likelihood quantum-state tomography, one must find the quantum state that maximizes the likelihood of the state given observed measurements on identically prepared systems. The optimization is usually performed with iterative algorithms. This paper provides a gradient-based upper bound on the ratio of the true maximum likelihood and the likelihood of the state of the current iteration, regardless of the particular algorithm used. This bound is useful for formulating stopping rules for halting iterations of maximization algorithms. We discuss such stopping rules in the context of determining confidence regions from log-likelihood differences when the differences are approximately chi-squared distributed.
description: 9 pages, single column, 1 figure. Updated to accepted manuscript version. Now includes section headings and other small editorial changes
Raysymmela Saylor 1947
Creators: name: Allsopp, Peter G.
name: Schoolmeesters, Paul
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Raysymmela

description: Raysymmela Saylor, 1947
[9 species].
Type species Symmela bruchi Moser, 1924, by original designation.
description: Published as part of Allsopp, Peter G. & Schoolmeesters, Paul, 2024, All genera of the world: Subfamilies Prototroginae, Cretoscarabaeinae, Dynamopodinae, Electrorubesopsinae, Phaenomeridinae, Orphninae, Allidiostomatinae, Aclopinae, Lichniinae, Melolonthinae, Oncerinae, Podolasiinae, Sericinae, Sericoidinae (Animalia: Arthropoda: Insecta: Coleoptera: Scarabaeidae), pp. 104-175 in Megataxa 12 (1) on page 146, DOI: 10.11646/megataxa.12.1.2, http://zenodo.org/record/14984437
The paradox of going that extra mile : how Organizational Citizenship Behavior relates to work engagement
Creators: name: Lau, Colleen Chung Yin
Publisher: name: University of British Columbia
Year: 2013

description: Organizational Citizenship Behavior (OCB) has been defined as employee behavior that is discretionary, not explicitly recognized by the formal reward system, yet contributes to the effective functioning of the organization (Organ, 1988). Although OCB contributes to positive outcomes at the organizational and team levels of analysis (Podsakoff, MacKenzie, Paine, & Bachrach, 2000), the results are mixed at the individual level (Podsakoff et al., 2000; Bolino, Turnley, Gilstrap, & Suazo, 2010). Also, a debate exists concerning whether discretion is an essential part of its definition. The present research examines whether perceived choice (i.e. role discretion) is a condition that influences the association between OCB and work engagement. Theoretical, research and practical implications are discussed.
Attitudes and Preferences towards Soil-Based Ecosystem Services: How Do They Vary across Space?
Creators: name: Eusse-Villa, Luisa Fernanda
name: Franceschinis, Cristiano
name: Thiene, Mara
name: Meyerhoff, Jürgen
name: McBratney, Alex
name: Field, Damien
Publisher: name: Technische Universität Berlin
Year: 2021
Subjects: subject: 577 Ökologie
subject: soil ES
subject: choice experiment
subject: preference heterogeneity

description: Soil ecosystem services (ES) provide multiple benefits to human well-being, but the failure to appreciate them has led to soil degradation issues across the globe. Despite an increasing interest in the threats to soil resources, economic valuation in this context is limited. Importantly, most of the existing valuation studies do not account for the spatial distribution of benefits that soil ES provide to the population. In this study, we present the results of a choice experiment (CE) aimed at investigating spatial heterogeneity of attitudes and preferences towards soil conservation and soil ES. We explored spatial heterogeneity of both attitudes and welfare measures via GIS techniques. We found that citizens of the Veneto Region (Northeast Italy) generally have positive attitudes towards soil conservation. We also find positive willingness-to-pay (WTP) values for soil ES in most of the study area and a considerable degree of heterogeneity in the spatial taste distribution. Finally, our results suggest that respondents with pro-environmental attitudes display a higher WTP based on the geographic pattern of the distribution of WTP values and attitudinal scores across the area.
Spicomacrurus Okamura 1970
Creators: name: Schwarzhans, Werner
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Gadiformes
Macrouridae
Spicomacrurus

description: Spicomacrurus Okamura, 1970
 Spicomacrurus Okamura 1970: 63, as subgenus of Hymenogadus Gilbert & Hubbs, 1920, type species by original designation Hymenocephalus kuronumai Kamohara, 1938.
 Hymenocephalus (Spicomacrurus): Iwamoto & Merrett 1997: 514.
 Spicomacrurus: Iwamoto, Shao & Ho, 2011: 514.
 Diagnosis. Modified from Iwamoto et al. (2011) Leading spine of dorsal fin smooth. Ventral striae consisting of fine parallel lines of dark, alternating with silvery pigment associated with light-producing function on abdominal wall, parts of chest, and shoulder girdle, not joint at median line behind pelvic fin bases. Head not cavernous. Nasal bones forming broad, horizontal, lateral, and medial plate-like processes; nasal bones of both sides in broad contact (two species), or widely separated by rostral cartilage (two species). Gill rakers 9–15. Additional diagnostic features from otolith morphology are: Elongate shape of otoliths (OL:OH = 1.45–1.95); otoliths thin due to slightly concave outer face; relatively low and short predorsal lobe; ventral sulcus margin at collum indented; pseudocolliculum indistinct, short.
 Comparison. Spicomacrurus is remarkable for the spectacular specialization of its broad spatulate nasal bones (see above). It further differs from the related genera Hymenogadus and Hymenocephalus by the lack of the cavernous cephalic canal system covered by thin skin (integument). It shares with Hymenogadus the short ventral striae, which are not joined along the mesial line behind the pelvic fin bases, and the rather slender otoliths with the narrow, ventrally indented collum and the short pseudocolliculum.
 Species. Four species, all from the western Pacific, S. adelscotti, S. dyctiogadus, S. kuronumai and S. mccoskeri.
description: Published as part of Schwarzhans, Werner, 2014, Head and otolith morphology of the genera Hymenocephalus, Hymenogadus and Spicomacrurus (Macrouridae), with the description of three new species, pp. 1-73 in Zootaxa 3888 (1) on pages 19-20, DOI: 10.11646/zootaxa.3888.1.1, http://zenodo.org/record/10086415
Spicomacrurus kuronumai
Creators: name: Schwarzhans, Werner
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Gadiformes
Macrouridae
Spicomacrurus
Spicomacrurus kuronumai

description: Spicomacrurus kuronumai (Kamohara, 1938)
Figs. 3E–F, 4E–G, 5
 Hymenocephalus kuronumai Kamohara, 1938: 70 (type locality: Tosa Bay).
 Hymenogadus (Spicomacrurus) kuronumai: Okamura, 1970: 64.
 Spicomacrurus kuronumai: Iwamoto, Shao & Ho, 2011: 515.
 Material examined. 2 specimens; 1 specimen NSMT 46796, 164 mm TL, 34°57’N, 138°43’E, 315–500m; 1 specimen NSMT 103488, 157 mm TL, 31°29–32’N, 128°30–31’E, 550– 596 m.
 Diagnosis. Pelvic fin rays 8; nasal bones closely adjoining along mesial edges, forming three horizontal plate like processes; OL:OH = 1.45–1.6.
 Comparison. For distinction from S. adelscotti see above. Spicomacrurus kuronumai also resembles S. mccoskeri, from which it differs in the number of pelvic fin rays (8 vs 9), the robust head shape (head length: height = 1.7 vs 2.3) and the more compressed otolith (OL:OH = 1.45–1.6 vs 1.95). Spicomacrurus kuronumai shows scale pockets on the occiput, a character otherwise only shared with S. dictyogadus.
 Description. Head morphology (Figs. 3E–F): Head length to height about 1.7 with relatively firm head bones and platy spatulate nasal bones closely adjoining along mesial edges. Scales or scale pockets present on occiput in small patches behind nasal bones and in front of nape and in a row covering the skin over the supraorbital canal. Snout length 20% HL, orbit diameter 30–33% HL, interorbital width 35% HW. Barbel 15% HL, reaching vertical through center of orbit. Infraorbital, supraorbital and preopercular canal systems narrow with widths <10% HL, covered by rather thick, firm skin. Few small pores visible in skin of infraorbital and in posterior mandibular positions. Preopercular angle broad, not projecting.
Otolith morphology (Figs. 4E–G): Thin and moderately elongate otoliths with slightly convex inner and flat outer face. OL:OH = 1.45–1.6; OH:OT = 6. Predorsal lobe low, rather indistinct; ventral rim similarly deep; anterior tip blunt, posterior tip rounded. Rims often somewhat ornamented; postdorsal section deeply indented in one specimen (Fig. 4G). Sulcus slightly supramedian with narrow, ventrally indented collum. Colliculi large, reaching close to anterior and posterior rims of otolith, caudal colliculum only slightly longer than ostial colliculum (CCL: OCL = 1.0–1.2); pseudocolliculum indistinct, short; TCL: PCL = 7–8. Dorsal depression large; ventral furrow distinct, turning upwards and away from ventral rim posteriorly.
 Distribution. (Fig. 5) Off southeastern Japan (Okamura, 1970) to northern Taiwan (Iwamoto et al., 2011).
description: Published as part of Schwarzhans, Werner, 2014, Head and otolith morphology of the genera Hymenocephalus, Hymenogadus and Spicomacrurus (Macrouridae), with the description of three new species, pp. 1-73 in Zootaxa 3888 (1) on pages 21-22, DOI: 10.11646/zootaxa.3888.1.1, http://zenodo.org/record/10086415
Rhynchoserica Burgeon 1942
Creators: name: Allsopp, Peter G.
name: Schoolmeesters, Paul
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Rhynchoserica

description: Rhynchoserica Burgeon, 1942
[2 species].
Type species Rhynchoserica rostrata Burgeon, 1942, by monotypy.
description: Published as part of Allsopp, Peter G. & Schoolmeesters, Paul, 2024, All genera of the world: Subfamilies Prototroginae, Cretoscarabaeinae, Dynamopodinae, Electrorubesopsinae, Phaenomeridinae, Orphninae, Allidiostomatinae, Aclopinae, Lichniinae, Melolonthinae, Oncerinae, Podolasiinae, Sericinae, Sericoidinae (Animalia: Arthropoda: Insecta: Coleoptera: Scarabaeidae), pp. 104-175 in Megataxa 12 (1) on page 146, DOI: 10.11646/megataxa.12.1.2, http://zenodo.org/record/14984437
Sayloria Frey 1975
Creators: name: Allsopp, Peter G.
name: Schoolmeesters, Paul
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Sayloria

description: Sayloria Frey, 1975, as Symmela (Sayloria)
[3 species].
Type species Astaena bicoloripes Saylor, 1946, by monotypy. Status revised to Sayloria by Pacheco et al. (2021).
description: Published as part of Allsopp, Peter G. & Schoolmeesters, Paul, 2024, All genera of the world: Subfamilies Prototroginae, Cretoscarabaeinae, Dynamopodinae, Electrorubesopsinae, Phaenomeridinae, Orphninae, Allidiostomatinae, Aclopinae, Lichniinae, Melolonthinae, Oncerinae, Podolasiinae, Sericinae, Sericoidinae (Animalia: Arthropoda: Insecta: Coleoptera: Scarabaeidae), pp. 104-175 in Megataxa 12 (1) on page 146, DOI: 10.11646/megataxa.12.1.2, http://zenodo.org/record/14984437
Microtubules immuno-labeled with Alexa 647 with widefield images 60-64
Creators: name: SINGH, Manish
Publisher: name: Zenodo
Year: 2021
Subjects: shareloc.xyz
shareloc.xyz:dataset
dstorm
u373
microtubules
alexa-647
indirect-immuno-labeling
alpha-tubulin
2d
em-ccd
thunderstorm
gluox
pfa+gluta
smlm

description: Open in Shareloc.XYZ

description: dSTORM images of microtubules with widefield images, Alpha-tubulin immuno-labeled with Alexa 647 in U373 cells, reconstructed by ThunderSTORM plugin (Uploaded via https://shareloc.xyz)
On the Stern sequence and its twisted version
Creators: name: Allouche, Jean-Paul
Publisher: name: arXiv
Year: 2012
Subjects: subject: Number Theory (math.NT)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 11B83, 11B85

description: In a recent preprint on ArXiv, Bacher introduced a twisted version of the Stern sequence. His paper contains in particular three conjectures relating the generating series for the Stern sequence and for the twisted Stern sequence. Soon afterwards Coons published two papers in {\it Integers}: first he proved these conjectures, second he used his result to obtain a correlation-type identity for the Stern sequence. We recall here a simple result of Reznick and we state a similar result for the twisted Stern sequence. We deduce an easy proof of Coons' identity, and a simple proof of Bacher's conjectures. Furthermore we prove identities similar to Coons' for variations on the Stern sequence that include Bacher's sequence.
The Inflammatory Calcium Binding Protein S100A8 and Its N-Terminal Proteolytic Fragment Interact with Transforming Growth Factor-Beta1 (TGF-b1) and Alter Akt, mTOR and NF-kappa B Cancer Cell Signalling
Creators: name: Bozzato, Dania
name: Moz, Stefania
name: Padoan, Andrea
name: Scorzeto, Michele
name: Fogar, Paola
name: Sperti, Cosimo
name: Greco, Eliana
name: Zambon, Carlo Federico
name: Navaglia, Filippo
name: Pelloso, Michele
name: Rossi, Elisa
name: Pasquali, Claudio
name: Pedrazzoli, Sergio
name: Reggiani, Carlo
name: Plebani, Mario
name: Basso, Daniela
Publisher: name: JOP. Journal of the Pancreas
Year: 2012
Subjects: Meeting Abstracts; Pancreas

description: Context S100A8 is highly expressed by stromal cells in pancreatic cancer when SMAD4 is not mutated or by cancer cells when SMAD4 is mutated, suggesting a link between TGF-β1 and S100A8 pathways. The proteolytic fragment of S100A8, NT-S100A8, highly abundant in pancreatic cancer, is involved in altering insulin secretion and action. Objective To ascertain whether S100A8 and NT-S100A8 interacts with TGF-β1 in altering intracellular calcium, NF-kappa B, Akt and mTOR signalling. Methods BxPC3 cells were stimulated with S100A8 (10 nM), NT-S100A8 (50 nM) alone or combined with TGF-β1 (0.02 ng/mL). Intracellular calcium was monitored by Fluo4 (epifluroescence). Akt (Ser473,Thr308), mTOR (Ser2448), NF-kappa B (p-IkB-a) were WB analyzed. Results NT-S100A8 evoked a train of intracellular calcium fluxes after 150-second lag time, which was reduced to few seconds in the presence of TGF-β1. S100A8 or TGF-β1 alone did not alter intracellular calcium. NF-kappa B signalling was activated in a calcium-dependent manner by S100A8 and by NT-S100A8 in the presence of TGF-β1. Akt Ser473 phosphorylation was reduced by NT-S100A8, TGF-β1 but mainly by their combination. AktThr308 was not affected by the studied molecules. mTOR phosphorylation (Ser2448) was induced by S100A8 and, at a lesser degree, by TGF-β1 and NT-S100A8. The phosphorylation (Ser235/236) of the downstream effector of mTORC1, S6RB, was reduced by TGF-β1 and NT-S100A8 independently, not by S100A8. Conclusion NT-S100A8 mimics TGF-β1 inhibitory effects on Akt and mTOR signalling. These two molecules co-operate in inhibiting Akt probably by altering intracellular calcium, while they co-operate in activating NF-kappa B in a calcium-independent manner mimicking the entire S100A8 molecule effect.
description: JOP. Journal of the Pancreas, Vol 13, N° 5S (2012): September (Suppl.) - p. 548-650
Dissipationless Formation and Evolution of the Milky Way Nuclear Star Cluster
Creators: name: Antonini, Fabio
name: Capuzzo-Dolcetta, Roberto
name: Mastrobuono-Battisti, Alessandra
name: Merritt, David
Publisher: name: arXiv
Year: 2011
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Abridged: In one widely discussed model for the formation of nuclear star clusters (NSCs), massive globular clusters spiral into the center of a galaxy and merge to form the nucleus. It is now known that at least some NSCs coexist with supermassive black holes (SBHs); this is the case, for instance, in the Milky Way (MW). In this paper, we investigate how the presence of a SMBH at the center of the MW impacts the merger hypothesis for the formation of its NSC. Starting from a model consisting of a low-density nuclear stellar disk and the SMBH, we use N-body simulations to follow the successive inspiral and merger of globular clusters. The clusters are started on circular orbits of radius 20 pc, and their initial masses and radii are set up in such a way as to be consistent with the galactic tidal field at that radius. The total accumulated mass by ~10 clusters is about 1.5x10^7 Solar masses. Each cluster is disrupted by the SMBH at a distance of roughly one parsec. The density profile that results after the final inspiral event is characterized by a core of roughly this radius, and an envelope with density that falls off as 1/r^2. These properties are similar to those of the MW NSC, with the exception of the core size, which in the MW is a little smaller. But by continuing the evolution of the model after the final inspiral event, we find that the core shrinks substantially via gravitational encounters in a time (when scaled to the MW) of 10 Gyr as the stellar distribution evolves toward a Bahcall-Wolf cusp. We also show that the luminosity function of the MW NSC is consistent with the hypothesis that a large fraction of the mass comes from (~10Gyr) old stars, brought in by globular clusters. We conclude that a model in which a large fraction of the mass of the MW NSC arose from infalling globular clusters is consistent with existing observational constraints.
description: 15 pages, 13 figures. ApJ accepted
Spicomacrurus dictyogadus Iwamoto, Shao & Ho 2011
Creators: name: Schwarzhans, Werner
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Gadiformes
Macrouridae
Spicomacrurus
Spicomacrurus dictyogadus

description: Spicomacrurus dictyogadus Iwamoto, Shao & Ho, 2011
Figs. 3A–B, 5
 Spicomacrurus dictyogadus Iwamoto, Shao & Ho, 2011: 518 (type locality: 16°18’S, 167°46’E).
 Discussion. The unique holotype of S. dictyogadus (MNHN 2009-1455) was visually inspected, but no otolith was extracted and no additional observations were made to the description of Iwamoto et al. (2011), and the figure included is based on their detailed photographs. The species is remarkable for its blunter head profile with barely protruding, short and not spatulate nasal bones, characters which are considered plesiomorphic in respect to the other members of the genus.
description: Published as part of Schwarzhans, Werner, 2014, Head and otolith morphology of the genera Hymenocephalus, Hymenogadus and Spicomacrurus (Macrouridae), with the description of three new species, pp. 1-73 in Zootaxa 3888 (1) on page 20, DOI: 10.11646/zootaxa.3888.1.1, http://zenodo.org/record/10086415
Pancreatic Cancer (PaCa)-Derived Soluble Mediators Induce Dendritic Cells (DC) to Acquire an Immunosuppressive Phenotype by Downregulating CTLA4
Creators: name: Gnatta, Elisa
name: Fogar, Paola
name: Aita, Ada
name: Frasson, Chiara
name: Teolato, Sara
name: Facco, Monica
name: Bozzato, Dania
name: Greco, Eliana
name: Padoan, Andrea
name: Navaglia, Filippo
name: Moz, Stefania
name: Zambon, Carlo Federico
name: Semenzato, Giampietro
name: Basso, Giuseppe
name: Plebani, Mario
name: Basso, Daniela
Publisher: name: JOP. Journal of the Pancreas
Year: 2012
Subjects: Meeting Abstracts; Pancreas

description: Context An altered function of lymphocytes, DC and immature myeloid cells appears to be an hallmark of tumor-mediated immune suppression and the two inhibitory co-stimulatory receptors PDL-1 and CTLA4 might have a role in this context. Objective The aim of the present in vitro study was to assess whether PaCa cells cross-talk with normal mononuclear circulating cells (PBMC) causing them to acquire an immune­suppressive phenotype and to evaluate whether PDL1 and CTLA4 are involved. Methods PBMC from blood donors were cultured for 4 days in control (CTL) and in the PaCa cancer cell line Capan1 conditioned media (CM). Lymphocytes subsets (CD4+, CD8+, CD4+CD25+) and CD33+ immature myeloid cells subsets (CD14+/-; HLA-DR+/-) expressing or not PDL1 and/or CTLA4 were analyzed by flow cytometry. To assess immunosuppressive function, myeloid cells were FACS sorted and co-cultured with allogenic total T lymphocytes in 1:20 and 1:40 ratios. Total T lymphocytes proliferation was determined by 3H-thymidine uptake. Results Capan1 CM caused an expansion of CD4+CD25+ (P=0.01) and a reduction of CD33+CD14-HLA-DR+ (P=0.03) cells. In this latter cellular subset, CM caused also an increase of PDL1 (P=0.046) and a decrease of CTLA4 (P=0.05) positive cells. FACS sorted CTL and CM CD33+CD14-HLA-DR+ cells did not significantly affect the proliferation of allogenic total T lymphocytes both at 1:20 (P=0.54) or at 1:40 ratios (P=0.81). The CD33+CD14-HLA-DR+ PDL-1+ cells did not significantly modify allogenic T cells proliferation with respect to PDL- cells (P=0.11), while those cells which were CTLA4 negative caused a significant inhibition of T cell proliferation in comparison of CTLA4 positive cells (P=0.008). Conclusions PaCa-derived soluble factors induce the expansion of the inhibitory lymphocyte subset CD4+CD25+ and a reduction of the immature CD33+CD14-DR+ dendritic cells. The tumor associated reduced expression of the inhibitory molecule CTLA4 in this cell population was demonstrated to characterize an immunosuppressive phenotype and this study suggests to take care in the use of anti-CTLA4 therapies.
description: JOP. Journal of the Pancreas, Vol 13, N° 5S (2012): September (Suppl.) - p. 548-650
Hitting time for Bessel processes - walk on moving spheres algorithm (WoMS)
Creators: name: Deaconu, Madalina
name: Herrmann, Samuel
Publisher: name: arXiv
Year: 2011
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: In this article we investigate the hitting time of some given boundaries for Bessel processes. The main motivation comes from mathematical finance when dealing with volatility models, but the results can also be used in optimal control problems. The aim here is to construct a new and efficient algorithm in order to approach this hitting time. As an application we will consider the hitting time of a given level for the Cox-Ingersoll-Ross process. The main tools we use are on one side, an adaptation of the method of images to this particular situation and on the other side, the connection that exists between Cox-Ingersoll-Ross processes and Bessel processes.
description: Published in at http://dx.doi.org/10.1214/12-AAP900 the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Spicomacrurus adelscotti
Creators: name: Schwarzhans, Werner
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Gadiformes
Macrouridae
Spicomacrurus
Spicomacrurus adelscotti

description: Spicomacrurus adelscotti (Iwamoto & Merrett, 1997)
Figs. 3C–D, 4A–B, 5
 Hymenocephalus (Spicomacrurus) adelscotti Iwamoto & Merrett, 1997: 514 (type locality: 11°54’S, 179°31’W); Iwamoto & Williams, 1999: 176.
 Material examined. 1 specimen WAM P.28073-004, 154+ mm TL, 17°45’S, 118°32’E, 600– 690 m.
 Diagnosis. Pelvic fin rays 9; nasal bones closely adjoining along mesial edges, forming three horizontal platelike processes; OL:OH = 1.75.
 Comparison. Spicomacrurus adelscotti most closely resembles S. kuronumai, differing in the number of pelvic fin rays (9 vs 8), the more elongate head shape (head length: height = 2.1 vs 1.7) and the more elongate otolith (OL:OH = 1.75 vs 1.45–1.6). The occiput does not show any relict of scales or scale pockets as do the studied specimens of S. kuronumai.
 Description. Head morphology (Figs. 3C–D): Head length to height about 2.1 with relatively firm head bones and platy spatulate nasal bones closely adjoining along mesial edges. No indication of scales on head. Snout length 26% HL, orbit diameter 29% HL, interorbital width 40% HW. Barbel 18% HL, reaching vertical through center of orbit. Infraorbital, supraorbital and preopercular canal systems narrow with widths <8% HL, covered by rather thick, firm skin. One small pore visible in anterior section of infraorbital skin. Preopercular angle broad, not projecting.
Otolith morphology (Fig. 4A–B): Thin, elongate otoliths with slightly convex inner and slightly concave outer face. OL:OH = 1.75; OH:OT = 4. Predorsal lobe moderately developed, narrow; ventral rim shallow; anterior tip blunt, posterior tip moderately pointed. Sulcus slightly supramedian with narrow, ventrally-indented collum. Colliculi large, reaching close to anterior and posterior rims of otolith, caudal colliculum about 1½ times the length of ostial colliculum; pseudocolliculum indistinct, short; TCL:PCL = 9. Dorsal depression large; ventral furrow distinct, turning upwards and away from ventral rim posteriorly.
 Distribution. (Fig. 5) Known from only two specimens, the holotype off northern Fiji, and the examined specimen from off Western Australia.
description: Published as part of Schwarzhans, Werner, 2014, Head and otolith morphology of the genera Hymenocephalus, Hymenogadus and Spicomacrurus (Macrouridae), with the description of three new species, pp. 1-73 in Zootaxa 3888 (1) on page 20, DOI: 10.11646/zootaxa.3888.1.1, http://zenodo.org/record/10086415
Selaserica Brenske 1898
Creators: name: Allsopp, Peter G.
name: Schoolmeesters, Paul
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Selaserica

description: Selaserica Brenske, 1898c
[27 species].
Type species Serica nitida Candèze, 1861, by monotypy.
description: Published as part of Allsopp, Peter G. & Schoolmeesters, Paul, 2024, All genera of the world: Subfamilies Prototroginae, Cretoscarabaeinae, Dynamopodinae, Electrorubesopsinae, Phaenomeridinae, Orphninae, Allidiostomatinae, Aclopinae, Lichniinae, Melolonthinae, Oncerinae, Podolasiinae, Sericinae, Sericoidinae (Animalia: Arthropoda: Insecta: Coleoptera: Scarabaeidae), pp. 104-175 in Megataxa 12 (1) on page 146, DOI: 10.11646/megataxa.12.1.2, http://zenodo.org/record/14984437
Dynamical dispersion relation for ELKO dark spinor fields
Creators: name: Bernardini, Alex E.
name: da Rocha, Roldao
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: An intrinsic mass generation mechanism for exotic ELKO dark matter fields is scrutinized, in the context of the very special relativity (VSR). Our results are reported on unraveling inequivalent spin structures that educe an additional term on the associated Dirac operator. Contrary to the spinor fields of mass dimension 3/2, this term is precluded to be absorbed as a shift of some gauge vector potential, regarding the equations for the dark spinor fields. It leads to some dynamical constraints that can be intrinsically converted into a dark spinor mass generation mechanism, with the encoded symmetries maintained by the VSR. The dynamical mass is embedded in the VSR framework through a natural coupling to the kink solution of a λϕ^{4} theory for a scalar field ϕ. Our results evince the possibility of novel effective scenarios, derived from exotic couplings among dark spinor fields and scalar field topological solutions.
description: 6 pages, to appear in Phys.Lett.B
EUS-guided FNA for proliferative rate in pancreatic neuroendocrine tumors: a single center experience over a 11-year period.
Creators: name: Petrone, Maria Chiara
name: Testoni, Sabrina Gloria Giulia
name: Carrara, Silvia
name: Balzano, Gianpaolo
name: Manzoni, Marco
name: Doglioni, Claudio
name: Testoni, Pier Alberto
name: Arcidiacono, Paolo Giorgio
Publisher: name: JOP. Journal of the Pancreas
Year: 2012
Subjects: Meeting Abstracts; Pancreas

description: Context Pancreatic neuroendocrine tumors (PNTs) are rare, representing 1% to 2% of all pancreatic neoplasms. Endoscopic ultrasonography in combination with fine needle aspiration (EUS-FNA) has been shown to be an highly accurate method for the preoperative localization and diagnosis of PNTs and several studies have shown that proliferative activity index (Ki-67) represents one of the most important criteria of malignancy. Objective The aim of this study was to evaluate the role of EUS-FNA in the assessment of the proliferation index (Ki-67) expression on cytological material in a consecutive cohort with histologically confirmed PNT. Methods Data of all consecutive patients undergone EUS-FNA of pancreatic mass over a 11-year period, were prospectively stored in a data base. All cases with both cytological and histological diagnosis of PNT were evaluated for the present study. Pre-surgical FNAs’ immunocytochemical results (Ki-67) were compared to the corresponding findings obtained from surgical specimens. We categorized Ki-67 expression using a cut-off of 2% (Ki-67≤2% and Ki-67>2%). Results About 2,000 pancreatic mass FNAs were performed over a 11-year period. Eighty-two patients (mean age 55.6±14.3 years) had cytological diagnosis of PNT, of whom 78 had confirmed histopathology. Sensitivity of EUS-FNA for the diagnosis of a PNT was 87.5%. The mean number of needle passes to obtain adequate sample was 2.6±0.98. Proliferative index was evaluable in 35 FNAs (44.8%); in the remaining patients we could not measure Ki-67 because not enough material was left after performing routine staining. When using a cut-off of 2%, Ki-67 expression measured was concordant in 17 out of 22 and the remaining 5 cases were discordant. When using a cut-off >2%, Ki-67 expression was concordant in 11 out of 13. Overall concordance between cytological and histological samples for Ki-67 was 80% (28/35). Kappa statistics was 0.64 (95% CI: 0.25-0.83). Sensitivity and specificity of FNAs for Ki-67 were 0.79 (95% CI: 0.61-0.91) and 0.69 (95% CI: 0.48-0.83), respectively (P value=0.007). Conclusion It is possible to determine proliferative index in PNTs on cytological material obtained by EUS-FNAs with an overall good agreement in the expression of Ki-67 measured either on cellular material and on histological tissue. The cytological Ki-67 may effectively improve the preoperative assessment of PNTs. A careful quantitative analysis of specimens at the time of FNA should be done in order to ensure sufficient material for Ki-67 assessment.
description: JOP. Journal of the Pancreas, Vol 13, N° 5S (2012): September (Suppl.) - p. 548-650
Moments of the transmission eigenvalues, proper delay times and random matrix theory II
Creators: name: Mezzadri, F.
name: Simm, N. J.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mathematical Physics (math-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences
subject: 15B52, 81V65

description: We systematically study the first three terms in the asymptotic expansions of the moments of the transmission eigenvalues and proper delay times as the number of quantum channels n in the leads goes to infinity. The computations are based on the assumption that the Landauer-Bütticker scattering matrix for chaotic ballistic cavities can be modelled by the circular ensembles of Random Matrix Theory (RMT). The starting points are the finite-n formulae that we recently discovered (Mezzadri and Simm, J. Math. Phys. 52 (2011), 103511). Our analysis includes all the symmetry classes beta=1,2,4; in addition, it applies to the transmission eigenvalues of Andreev billiards, whose symmetry classes were classified by Zirnbauer (J. Math. Phys. 37 (1996), 4986-5018) and Altland and Zirnbauer (Phys. Rev. B. 55 (1997), 1142-1161). Where applicable, our results are in complete agreement with the semiclassical theory of mesoscopic systems developed by Berkolaiko et al. (J. Phys. A.: Math. Theor. 41 (2008), 365102) and Berkolaiko and Kuipers (J. Phys. A: Math. Theor. 43 (2010), 035101 and New J. Phys. 13 (2011), 063020). Our approach also applies to the Selberg-like integrals. We calculate the first two terms in their asymptotic expansion explicitly.
description: 45 pages; typos corrected and 6 references added
Are There Predicting Factors Related to a “Soft Pancreas”?
Creators: name: Ricci, Claudio
name: Taffurelli, Giovanni
name: D’Ambra, Marielda
name: Buscemi, Salvatore
name: Peri, Eugenia
name: Pezzilli, Raffaele
name: Casadei, Riccardo
name: Minni, Francesco
Publisher: name: JOP. Journal of the Pancreas
Year: 2012
Subjects: Meeting Abstracts; Pancreas

description: Context It is well-known that a soft pancreatic stump is related to an increased incidence of postoperative pancreatic fistula (POPF) after pancreatic resection. Objectives To evaluate the presence of preoperative factors predicting soft pancreas in patients who underwent pancreaticoduodenectomy (PD) or left pancreatectomy (LP). Methods From January 2004 to June 2012, data regarding 208 consecutive patients whom underwent PD or LP were collected in a prospective database. For each patients we recorded sex, age, co-morbidities, BMI, ASA score, preoperative diagnosis, type of resection, characteristics of pancreatic remnant, pathological diagnosis and POPF rate. Univariate and multivariate analyses were carried out in order to evaluate the preoperative factors predicting a soft pancreatic stump. Results There were 102 (49%) female and 106 (51%) male with a mean age of 64.5±13.2 years. Co-morbidities were present in 128 (61.5%) patients; 64 patients (30.8%) were ASA II, 128 (61.5%) ASA III and 16 (7.7%) ASA IV. Mean BMI was 25.3±4.4 kg/m2. A pancreatic cancer or a chronic pancreatitis (CP) were suspected in 85 (40.9%) cases. One-hundred and twenty-five (60.1%) patients underwent PD and 83 (39.9%) LP. Pancreatic stump was soft in 129 (62%) cases and Wirsung duct was dilated in 55 cases (26.4%). Sixty-one patients (29.3%) had POPF (9.1% grade A; 19.2% grade B; and 1% grade C). Univariate analysis showed that a non dilated Wirsung duct (P<0.001), a pre-operative diagnosis different from pancreatic cancer or CP (P<0.001) and an increasing BMI value (P=0.002) were factors related to “soft pancreas”. Multivariate analysis confirmed that a non-dilated Wirsung duct and a preoperative diagnosis different from pancreatic cancer or CP were independent factors related to soft pancreas (OR: 4.1, 95% CI: 2.0-8.4, P<0.001; and OR: 3.6, 95% CI: 1.9-6.8, P<0.001; respectively). A BMI value best cut off of 24 kg/m2 was obtained by a ROC curve (AUC=0.607; P=0.010). A further multivariate analysis showed that the cut off of BMI resulted an independent factor predicting soft pancreas (OR 2.5, 95% CI: 1.2-4.8; P=0.009). Conclusion BMI value >24 kg/m2, a non dilated Wirsung duct and a pancreatic lesion different from pancreatic cancer or CP can predict a soft pancreas and subsequently a major risk of POPF.
description: JOP. Journal of the Pancreas, Vol 13, N° 5S (2012): September (Suppl.) - p. 548-650