cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Cobalt complexes based on 2-(1H-benzimidazol-2-yl)-phenol derivatives: preparation, spectral studies, DFT calculations and catalytic behavior toward ethylene oligomerization
Creators: name: Haghverdi, Marzieh
name: Azadeh Tadjarodi
name: Naeimeh Bahri-Laleh
name: Haghighi, Mahdi Nekoomanesh
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: In this study, five novel Co(II) complexes of 2-(1H-benzimidazol-2-yl)-phenol derivatives (HLx: x = 1–5) have been synthesized and characterized. The general formula for complexes C1 and C2 is K2[Co(HL1,2)2Cl2]·H2O, for complex C3 K2[Co(HL3)2Cl2], and for complexes C4 and C5 [Co(HL4,5)2]. In all complexes, the ligands are coordinated as bidentate, via one imine nitrogen and the phenolate oxygen atoms. The structures of the compounds were characterized by FT-IR, UV–vis, 1H, 13C NMR spectroscopies, ICP and elemental analysis (C, H, and N). The purity of these compounds was ascertained by melting point (m.p.) and TLC. Geometry optimization of the studied complexes was done by Gaussian09 software at B3LYP/TZVP level of theory and satisfactory theoretical–experimental agreement was achieved for NMR and IR spectra of the compounds. Based on the combined experimental and theoretical studies, six-coordinate octahedral structures have been proposed for complexes C1–C3, while complexes C4 and C5 had distorted tetrahedral geometry. All complexes were activated with diethylaluminum chloride (Et2AlCl), cobalt(II) complexes containing bulky methyl groups in the aryl moiety show high catalytic activities (1774 kg∙mol−1(Co)∙h−1) for ethylene oligomerization. The oligomers obtained from the cobalt complexes exhibit good selectivity for linear 1-butene and 1-hexene. Results revealed that both the steric and electronic effects of ligands strongly affect the catalytic activities and the properties of the catalytic products.
Del Tamaño De Un Fotón
Creators: name: Hernández, Pedro Javier Villanueva
Publisher: name: figshare
Year: 2017
Subjects: subject: 20301 Acoustics and Acoustical Devices; Waves
subject: FOS: Physical sciences
subject: Applied Physics
subject: Atomic Physics
subject: 20201 Atomic and Molecular Physics
subject: 20299 Atomic, Molecular, Nuclear, Particle and Plasma Physics not elsewhere classified
subject: 20399 Classical Physics not elsewhere classified
subject: 20501 Classical and Physical Optics
subject: 29902 Complex Physical Systems
subject: Computational Physics
subject: 20401 Condensed Matter Characterisation Technique Development
subject: 20402 Condensed Matter Imaging
subject: 20403 Condensed Matter Modelling and Density Functional Theory
subject: Condensed Matter Physics
subject: 20499 Condensed Matter Physics not elsewhere classified
subject: 20601 Degenerate Quantum Gases and Atom Optics
subject: 20404 Electronic and Magnetic Properties of Condensed Matter; Superconductivity
subject: 20302 Electrostatics and Electrodynamics
subject: Entropy
subject: 20602 Field Theory and String Theory
subject: 20303 Fluid Physics
subject: General Relativity
subject: 20502 Lasers and Quantum Electronics
subject: M-Theory
subject: Mechanics
subject: 29903 Medical Physics
subject: 20503 Nonlinear Optics and Spectroscopy
subject: 20202 Nuclear Physics
subject: 20599 Optical Physics not elsewhere classified
subject: 20203 Particle Physics
subject: 20504 Photonics, Optoelectronics and Optical Communications
subject: 29999 Physical Sciences not elsewhere classified
subject: Plasma Physics
subject: 20204 Plasma Physics; Fusion Plasmas; Electrical Discharges
subject: 20603 Quantum Information, Computation and Communication
subject: Quantum Mechanics
subject: 20604 Quantum Optics
subject: 20699 Quantum Physics not elsewhere classified
subject: 20405 Soft Condensed Matter
subject: 91308 Solid Mechanics
subject: FOS: Mechanical engineering
subject: Special Relativity
subject: 20406 Surfaces and Structural Properties of Condensed Matter
subject: 29904 Synchrotrons; Accelerators; Instruments and Techniques
subject: Thermodynamics
subject: 20304 Thermodynamics and Statistical Physics

description: ¿Cuál es el tamaño de un fotón?
Synthesis of Cyclohexene Carbonate Catalyzed by Polymer-Supported Catalysts
Creators: name: Cui, Ke
name: Liang, Zhengyong
name: Zhang, Jing
name: Zhang, Yadong
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology
subject: Microbiology
subject: FOS: Biological sciences
subject: Biochemistry
subject: Biophysics

description: A series of polystyrene-divinylbenzene cross-linked resin (PS)–supported zinc chloride catalysts were prepared in this study. They can efficiently catalyze the solventless cycloaddition of cyclohexene oxide with carbon dioxide in the presence of tetrabutylammonium bromide (TBAB) as cocatalyst under relatively mild reaction conditions. The catalyst is composed of carrier, connecting arm, ligand, and active ingredient. The connecting arms of different lengths can significantly affect the catalytic activity. Among these catalysts, the one using diethylene glycol as connecting arm and 2-aminopyridine as ligand, named PS-DEG-2ap-ZnCl2, showed the optimal catalytic performance. The yield of cyclohexene carbonate was 95.18% calculated by gas chromatographic analysis under the optimal conditions (393 K, 5 MPa, 6 h). Moreover, the catalyst showed good stability and reusability. From the viewpoint of industrial application, the catalyst is attractive because of its excellent catalytic efficiency on the synthesis of cyclohexene carbonate.
Cobalt complexes based on 2-(1H-benzimidazol-2-yl)-phenol derivatives: Preparation, spectral studies, DFT calculations and catalytic behavior toward ethylene oligomerization
Creators: name: Haghverdi, Marzieh
name: Azadeh Tadjarodi
name: Naeimeh Bahri-Laleh
name: Haghighi, Mahdi Nekoomanesh
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: In this study, five novel Co(II) complexes of 2-(1H-benzimidazol-2-yl)-phenol derivatives (HLx: x = 1-5) have been synthesized and characterized. The general formula for complexes C1 and C2 is K2[Co(HL1,2)2Cl2]·H2O, for complex C3 K2[Co(HL3)2Cl2], and for complexes C4 and C5 [Co(HL4,5)2]. In all complexes, the ligands are coordinated as bidentate, via one imine nitrogen and the phenolate oxygen atoms. The structures of the compounds were characterized by FT-IR, UV-Vis, 1H-, 13C-NMR spectroscopies, ICP and elemental analysis (C, H and N). The purity of these compounds was ascertained by melting point (m.p.) and TLC. Geometry optimization of the studied complexes was done by Gaussian09 software at B3LYP/TZVP level of theory and satisfactory theoretical–experimental agreement was achieved for NMR and IR spectra of the compounds. Based on the combined experimental and theoretical studies, six-coordinate octahedral structures have been proposed for complexes C1-C3, while complexes C4 and C5 had distorted tetrahedral geometry. All complexes were activated with diethylaluminum chloride (Et2AlCl), cobalt(II) complexes containing bulky methyl groups in the aryl moiety show high catalytic activities (1774 kg∙mol−1(Co)∙h−1) for ethylene oligomerization. The oligomers obtained from the cobalt complexes exhibit good selectivity for linear 1-butene and 1-hexene. Results revealed that both the steric and electronic effects of ligands strongly affect the catalytic activities and the properties of the catalytic products.
Dimensões essenciais da cultura: um seu estudo diferencial e categorial: elementos para uma filosofia da cultura
Creators: name: Silva, Carlos Henrique Do Carmo
Publisher: name: Didaskalia
Year: 1999

description: Didaskalia, v. 29 n. 1-2 (1999): In Honorem D. José Policarpo: Patriarca de Lisboa e Magno Chanceler da Universidade Católica Portuguesa
Synthesis of Cyclohexene Carbonate Catalyzed by Polymer-Supported Catalysts
Creators: name: Cui, Ke
name: Liang, Zhengyong
name: Zhang, Jing
name: Zhang, Yadong
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology
subject: Microbiology
subject: FOS: Biological sciences
subject: Biochemistry
subject: Biophysics

description: A series of polystyrene-divinylbenzene cross-linked resin (PS) supported zinc chloride catalysts were prepared in this paper. They can efficiently catalyze the solventless cycloaddition of cyclohexene oxide with carbon dioxide in the presence of tetrabutylammonium bromide (TBAB) as co-catalyst under relatively mild reaction conditions. The catalyst is composed of carrier, connecting arm, ligand and active ingredient. The connecting arms of different lengths can significantly affect the catalytic activity. Among these catalysts, the one using diethylene glycol as connecting arm and 2-aminopyridine as ligand, which named PS-DEG-2ap-ZnCl2, showed the optimal catalytic performance. The yield of cyclohexene carbonate was 95.18% calculated by GC analysis under the optimal conditions (393 K, 5 MPa, 6 h). Moreover, the catalyst showed good stability and reusability. From the viewpoint of industrial application, the catalyst is attractive because of its excellent catalytic efficiency on the synthesis of cyclohexene carbonate.
Electronic cigarettes and health outcomes: systematic review of global evidence
Creators: name: Banks, Emily
name: Yazidjoglou, Amelia
name: Brown, Sinan
name: Nguyen, Mai
name: Martin, Melonie
name: Beckwith, Katie
name: Daluwatta, Amanda
name: Campbell, Sai
name: Joshy, Grace
Publisher: name: The Australian National University
Year: 2022
Subjects: vaping
e-cigarettes
electronic cigarettes
health outcomes
systematic review
nicotine

description: This report aims to provide a systematic overview of the contemporary evidence on the health effects of nicotine and non-nicotine e-cigarette use, excluding where possible use of tetrahydrocannabinol (THC) and other illicit substances. The primary health outcomes of interest include, but are not limited to: dependence; cardiovascular disease; cancer; respiratory disease; oral diseases; reproductive outcomes; injuries and poisonings; mental health conditions; and environmental hazards with human health implications. These findings are integrated with those from previous systematic reviews on smoking uptake and cessation.
Assessing Porcine Gastric and Trachea Mucin Antimicrobial Activity Against Pseudomonas Aeruginosa
Creators: name: Sokol, Zoe
Publisher: name: Digital Repository at the University of Maryland
Year: 2024
Subjects: Bioengineering
ENGR
Respiratory NanoBioengineering (RnB) Lab
ASPIRE
antimicrobial porcine mucin

description: Mucus is present throughout the human body, lining all wet epithelia, making it a native, familiar material to the innate immune system. The biocompatibility of mucus opens the possibility for therapeutic applications. Existing research has shown that exposure to mucus triggers the downregulation of virulence genes in some bacteria species and rapidly disintegrates biofilms. The aim of this project is to test the innate antimicrobial activity of porcine gastric mucin (PGM) and porcine trachea mucin (PTM) against Pseudomonas aeruginosa. We examined the antimicrobial activity of mucins by quantifying bacteria growth and viability at numerous time points after mucin treatment. To test this hypothesis, PAO1 cultures were grown in LB broth overnight. Mucin was added to the planktonic PAO1 cultures at various concentrations, 8%, 4%, 2%, 1%, and 0.5% w/v, with each concentration tested in triplicates. At the 3 hr, 6 hr, and 24 hr timepoints after mucin addition, samples were taken from each culture, diluted, and spot-plated. The plates were grown overnight and counted the next day to calculate the colony-forming units. Preliminary results suggest that increasing mucin concentration correlates with decreased bacterial growth, as hypothesized. Additionally, PGM possibly shows a greater degree of antimicrobial effect than PTM. This research has a great potential impact. Pseudomonas aeruginosa is an opportunistic pathogen often developing antibiotic resistance making it extremely difficult to treat and a high priority for novel treatment development. Therefore, a novel treatment method against P. aeruginosa can have broad implications and improve bacterial infection treatments.
Additional file 2 of Transcription factor FTZ-F1 regulates mosquito cuticular protein CPLCG5 conferring resistance to pyrethroids in Culex pipiens pallens
Creators: name: Xu, Yang
name: Yang, Xiaoshan
name: Sun, Xiaohong
name: Li, Xixi
name: Liu, Zhihan
name: Yin, Qi
name: Ma, Lei
name: Zhou, Dan
name: Sun, Yan
name: Shen, Bo
name: Zhu, Changliang
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Ecology
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology
subject: Computational Biology

description: Additional file 2: Table S2. PCR primers used to amplify the full-length FTZ-F1 and the promoter region of CPLCG5.
Aminopropyl group-modified SBA-15 covalent attachment Mn(salen) complexes as catalysts for styrene epoxidation
Creators: name: Liu, Lili
name: Hu, Jianglei
name: He, Jiaojiao
name: Lu, Haojie
name: Xu, Yong
name: Shi, Fengwei
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified

description: A series of aminopropyl group-modified ordered mesoporous silica materials impregnated with Mn(salen) were prepared using successive grafting procedures. The prepared composite catalysts were well characterized by inductively coupled plasma atomic emission spectroscopy, Fourier transform-infrared, UV–Vis diffuse reflectance spectroscopy, X-ray diffraction analysis, and transmission electron microscopy in order to confirm the structure integrities of the Mn(salen) units after the incorporation, to evidence the formation of a covalent bond between the starting Mn(salen) units and the aminopropyl group-modified SBA-15 matrix in the presence of NaOH by abstraction of an HCl molecule. These heterogeneous catalysts exhibited comparable catalytic activity and selectivity to those of the homogeneous counterpart in the epoxidation of styrene by using NaClO as oxidant. In addition, the effects of key reaction parameters, including the loadings of the neat Mn(salen), molar ratios of NaClO to styrene, and PPNO amount on the reactivity and selectivity, were also studied. Finally, the reusability of the prepared heterogeneous catalyst was evaluated.
Additional file 1 of Effect of probiotics on nasal and intestinal microbiota in people with high exposure to particulate matter ≤ 2.5 μm (PM2.5): a randomized, double-blind, placebo-controlled clinical study
Creators: name: Wu, Yongcan
name: Pei, Caixia
name: Wang, Xiaomin
name: Wang, Mingjie
name: Huang, Demei
name: Wang, Fei
name: Xiao, Wei
name: Wang, Zhenxing
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Computational Biology

description: Additional file 1. The SPIRIT Checklist.
Contagion Effects of Abusive Supervision Climate: A Multilevel Study
Creators: name: Khan, Shahid
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Abusive supervision climate (ASC) affects not only subordinates but also their colleagues who work in the same group; however, little is known about how it impacts them. To constitute an ASC at the group level, this research employed the referent-shift consensus model to aggregate subordinates’ perceptions of supervisory abuse. Furthermore, the present research examined the effects of ASC on subordinates’ anger and subsequent work performance. Specifically, drawing from the affective events theory (AET), this study examined the indirect effects of an ASC on group members’ organisational citizenship behaviour (OCB) and withdrawal, via the mediating role of anger. In addition, group members’ agreeableness and neuroticism were predicted to moderate the relationship between group members’ anger and work behaviours. Analyses of data collected from 51 work groups across different organisations and industries in Pakistan revealed that ASC was negatively related to OCBs, and that anger mediated the relationship between ASC and both outcomes (OCBs and withdrawal). In addition, agreeableness was found to moderate the effect of group members’ anger on OCBs, such that the negative relationship was stronger for group members who rated higher on agreeableness.
 The findings contribute to the abusive supervision literature by focusing on the largely overlooked group members’ aggregated perception of abusive supervision. In so doing, this study constituted ASC. In addition, the cross-level effects of ASC on group members’ behaviour has been examined via their anger as a mediating link in transmitting the adverse effects of ASC on group members’ OCBs and withdrawal, thereby explaining the process through which ASC affects group members’ behaviours. Furthermore, it incorporates their personality differences in order to better understand their behavioural responses in a negative emotional state (anger). Further theoretical contributions and practical implications are discussed at the conclusion of the document.
Stories for Country: Developing a Place-Based Pedagogy Based on Indigenous Ways of Knowing
Creators: name: Wilson, Benjamin
Publisher: name: The Australian National University
Year: 2022

description: Indigenous people have different ways of being, knowing, and doing. The ways that we educate our children led to the most sustainable society in the history of our planet, lasting well over 60 000 years. The pedagogical approaches of Indigenous Australians must surely have something to offer in the way of teaching sustainability, particularly considering the immense ecological, social, and economic challenges that loom just over the horizon. The Indigenous approach to learning is mainly built on developing in individuals a profound and lasting respect and affection for the places they inhabit through encouraging them to explore their own stories of connection to these localities, their histories, and Earth-kin. All we are is a story, and a good story is one of connection, obligation, and responsibility. This thesis uses a new methodological paradigm (Narrative Ecography) to develop the Stories for Country Pedagogy - a teaching and learning framework aligned with Indigenous processes and suitable for implementation in mainstream Australian schools. This approach is designed to help educators prepare students to enter into a more honourable relationship with Country, and thus develop in them the skills and capabilities to restore an ecological balance for the good of all humankind.
Approaches to Research Advocacy - Group Number 3
Creators: name: NORDP2017
Publisher: name: National Organization of Research Development Professionals
Year: 2017
Subjects: subject: 100504 Data Communications
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: Science Policy
subject: 160511 Research, Science and Technology Policy
subject: FOS: Political science

description: This was a pre-NORDP conference workshop where participants were asked to come up with ideas on the roles of researchers in advocating for their own research. For example, every scientist should be able to talk about their research, engage in the community around their research, and relay why they're doing what they're doing is important.
These bullet points were the findings and next steps researchers can take that resulted from group number 3 in the workshop.
Synthesis of Benzothiazoles by the Reaction of Disulfide and Aromatic Carboxylic Acid Promoted by PCL3 and DBU
Creators: name: Du, Guangyan
name: Zhu, Ning
name: Hong, Hailong
name: Han, Limin
name: Suo, Quanling
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Infectious Diseases
subject: FOS: Health sciences
subject: Mathematics
subject: FOS: Mathematics
subject: Ecology
subject: FOS: Biological sciences
subject: Science Policy
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Microbiology

description: GRAPHICAL ABSTRACT
Approaches to Research Advocacy - Group Gretchen
Creators: name: Hook-Barnard, India
name: NORDP2017
Publisher: name: National Organization of Research Development Professionals
Year: 2017
Subjects: subject: Uncategorized
subject: Science Policy
subject: 160511 Research, Science and Technology Policy
subject: FOS: Political science

description: This was a pre-NORDP conference workshop where participants were asked to come up with ideas on the roles of researchers in advocating for their own research. For example, every scientist should be able to talk about their research, engage in the community around their research, and relay why they're doing what they're doing is important.
These bullet points were the findings and next steps researchers can take that resulted from group run by Gretchen Kaiser in the workshop.
The nanofluidics of graphene oxide
Creators: name: SAMUEL TERENCE MARTIN
Publisher: name: Monash University
Year: 2017
Subjects: subject: 30604 Electrochemistry
subject: FOS: Chemical sciences
subject: 90404 Membrane and Separation Technologies
subject: FOS: Chemical engineering
subject: 20405 Soft Condensed Matter
subject: FOS: Physical sciences

description: An examination of the behaviour of ions in graphene oxide membranes reveals the roles that surface charge, chemical make-up and structure have to play in influencing ion transport. New fabrication methods and novel applications that leverage these properties are described.
Synthesis of benzothiazoles by the reaction of disulfide and aromatic carboxylic acid promoted by PCl3 and DBU
Creators: name: Du, Guangyan
name: Zhu, Ning
name: Hong, Hailong
name: Han, Limin
name: Suo, Quanling
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Infectious Diseases
subject: FOS: Health sciences
subject: Mathematics
subject: FOS: Mathematics
subject: Ecology
subject: FOS: Biological sciences
subject: Science Policy
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Microbiology

description: A new synthetic method for the synthesis of benzothiazoles via PCl3 and DBU promoted cleavage/acylation/cyclization tandem reaction of disulfides and aromatic carboxylic acids has been developed. PCl3 acted as both an acylating reagent and a disulfide cleaving reagent, which promoted disulfides of 2-aminobenzenethiol to react with aromatic carboxylic acid to produce benzothiazole derivatives.
Additional file 2 of Effect of probiotics on nasal and intestinal microbiota in people with high exposure to particulate matter ≤ 2.5 μm (PM2.5): a randomized, double-blind, placebo-controlled clinical study
Creators: name: Wu, Yongcan
name: Pei, Caixia
name: Wang, Xiaomin
name: Wang, Mingjie
name: Huang, Demei
name: Wang, Fei
name: Xiao, Wei
name: Wang, Zhenxing
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Computational Biology

description: Additional file 2. Informed consent materials.
Uma visão cristã do hinduísmo na primeira metade de Seiscentos
Creators: name: Thomaz, Luís Filipe F. R.
Publisher: name: Didaskalia
Year: 1999

description: Didaskalia, v. 29 n. 1-2 (1999): In Honorem D. José Policarpo: Patriarca de Lisboa e Magno Chanceler da Universidade Católica Portuguesa
Approximate Inference for Non-parametric Bayesian Hawkes Processes and Beyond
Creators: name: Zhang, Rui
Publisher: name: The Australian National University
Year: 2022

description: The Hawkes process has been widely applied to modeling self-exciting events including neuron spikes, earthquakes and tweets. To avoid designing parametric triggering kernels, the non-parametric Hawkes process has been proposed, in which the triggering kernel is in a non-parametric form. However, inference in such models suffers from poor scalability to large-scale datasets and sensitivity to uncertainty in the random finite samples. To deal with these issues, we employ Bayesian non-parametric Hawkes processes and propose two kinds of efficient approximate inference methods based on existing inference techniques. Although having worked as the cornerstone of probabilistic methods based on Gaussian process priors, most of existing inference techniques approximately optimize standard divergence measures such as the Kullback-Leibler (KL) divergence, which lacks the basic desiderata for the task at hand, while chiefly offering merely technical convenience. In order to improve them, we further propose a more advanced Bayesian inference approach based on the Wasserstein distance, which is applicable to a wide range of models. Apart from these works, we also explore a robust frequentist estimation method beyond the Bayesian field. Efficient inference techniques for the Hawkes process will help all the different applications that it already has, from earthquake forecasting, finance to social media. Furthermore, approximate inference techniques proposed in this thesis have the potential to be applied to other models to improve robustness and account for uncertainty.
Identification of secreted proteins that reflect autophagy dynamics within tumor cells
Creators: name: A. Kraya, Adam
name: Piao, Shengfu
name: Xu, Xiaowei
name: Zhang, Gao
name: Herlyn, Meenhard
name: Gimotty, Phyllis
name: Levine, Beth
name: K Amaravadi, Ravi
name: W Speicher, David
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Cancer
subject: Developmental Biology
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biotechnology
subject: Pharmacology
subject: Physiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biochemistry

description: Macroautophagy, a catabolic process of cellular self-digestion, is an important tumor cell survival mechanism and a potential target in antineoplastic therapies. Recent discoveries have implicated autophagy in the cellular secretory process, but potential roles of autophagy-mediated secretion in modifying the tumor microenvironment are poorly understood. Furthermore, efforts to inhibit autophagy in clinical trials have been hampered by suboptimal methods to quantitatively measure tumor autophagy levels. Here, we leveraged the autophagy-based involvement in cellular secretion to identify shed proteins associated with autophagy levels in melanoma. The secretome of low-autophagy WM793 melanoma cells was compared to its highly autophagic metastatic derivative, 1205Lu in physiological 3-dimensional cell culture using quantitative proteomics. These comparisons identified candidate autophagy biomarkers IL1B (interleukin 1, β), CXCL8 (chemokine (C-X-C motif) ligand 8), LIF (leukemia inhibitory factor), FAM3C (family with sequence similarity 3, member C), and DKK3 (dickkopf WNT signaling pathway inhibitor 3) with known roles in inflammation and tumorigenesis, and these proteins were subsequently shown to be elevated in supernatants of an independent panel of high-autophagy melanoma cell lines. Secretion levels of these proteins increased when low-autophagy melanoma cells were treated with the autophagy-inducing tat-BECN1 (Beclin 1) peptide and decreased when ATG7 (autophagy-related 7) was silenced in high-autophagy cells, thereby supporting a mechanistic link between these secreted proteins and autophagy. In addition, serum from metastatic melanoma patients with high tumor autophagy levels exhibited higher levels of these proteins than serum from patients with low-autophagy tumors. These results suggest that autophagy-related secretion affects the tumor microenvironment and measurement of autophagy-associated secreted proteins in plasma and possibly in tumors can serve as surrogates for intracellular autophagy dynamics in tumor cells.
Fact Sheet: The Nansen Legacy
Creators: name: The Nansen Legacy
Publisher: name: Zenodo
Year: 2024

description: This fact sheet is a deliverable of the project The Nansen Legacy, and it brings together core findings of the project. 

Scientific observations of many Nansen Legacy researchers form the background for this fact sheet. The following researchers have summarized the findings and provided the text on the fact sheet: M. Reigstad (lead), T. Eldevik, S. Gerland (alphabetical order, apart from lead scientist).

All illustrations and the design of the fact sheet have been made by F.A. Cnossen.
Targeted treatment of atherosclerosis with protein–polysaccharide nanoemulsion co-loaded with photosensitiser and upconversion nanoparticles
Creators: name: Huang, Jing
name: Xu, Shan
name: Liu, Lina
name: Zhang, Jiyuan
name: Xu, Jinzhuan
name: Zhang, Lili
name: Zhou, Xiang
name: Huang, Lei
name: Peng, Jianqing
name: Wang, Jianing
name: Gong, Zipeng
name: Chen, Yi
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Macrophages are the most abundant cell group in atherosclerosis (AS) lesions and play a vital role in all stages of AS progression. Recent research has shown that reactive oxygen species (ROS) generation from photodynamic therapy (PDT) induces macrophage autophagy to improve abnormal lipid metabolism and inflammatory environment. Especially in macrophage-derived foam cells, which has become a potential strategy for the treatment of AS. In this study, we prepared the conjugate (DB) of dextran (DEX) and bovine serum albumin (BSA). The DB was used as the emulsifier to prepare nanoemulsion loaded with upconversion nanoparticles (UCNPs) and chlorin e6 (Ce6) (UCNPs-Ce6@DB). The DEX modified on the surface of the nanoemulsion can recognise and bind to the scavenger receptor class A (SR-A) highly expressed on macrophages and promote the uptake of macrophage-derived foam cells in AS plates through SR-A-mediated endocytosis. In addition, UCNPs-Ce6@DB-mediated PDT enhanced ROS generation and induced autophagy in macrophage-derived foam cells, enhanced the expression of ABCA1, a protein closely related to cholesterol efflux, and inhibited the secretion of pro-inflammatory cytokines. Ultimately, UCNPs-Ce6@DB was shown to inhibit plaque formation in mouse models of AS. In conclusion, UCNPs-Ce6@DB offers a promising treatment for AS.
Identification of secreted proteins that reflect autophagy dynamics within tumor cells
Creators: name: A. Kraya, Adam
name: Piao, Shengfu
name: Xu, Xiaowei
name: Zhang, Gao
name: Herlyn, Meenhard
name: Gimotty, Phyllis
name: Levine, Beth
name: K Amaravadi, Ravi
name: W Speicher, David
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Cancer
subject: Developmental Biology
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biotechnology
subject: Pharmacology
subject: Physiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biochemistry

description: Macroautophagy, a catabolic process of cellular self-digestion, is an important tumor cell survival mechanism and a potential target in antineoplastic therapies. Recent discoveries have implicated autophagy in the cellular secretory process, but potential roles of autophagy-mediated secretion in modifying the tumor microenvironment are poorly understood. Furthermore, efforts to inhibit autophagy in clinical trials have been hampered by suboptimal methods to quantitatively measure tumor autophagy levels. Here, we leveraged the autophagy-based involvement in cellular secretion to identify shed proteins associated with autophagy levels in melanoma. The secretome of low-autophagy WM793 melanoma cells was compared to its highly autophagic metastatic derivative, 1205Lu in physiological 3-dimensional cell culture using quantitative proteomics. These comparisons identified candidate autophagy biomarkers IL1B (interleukin 1, beta), CXCL8 (chemokine (C-X-C motif) ligand 8), LIF (leukemia inhibitory factor), FAM3C (family with sequence similarity 3, member C), and DKK3 (dickkopf WNT signaling pathway inhibitor 3) with known roles in inflammation and tumorigenesis, and these proteins were subsequently shown to be elevated in supernatants of an independent panel of high-autophagy melanoma cell lines. Secretion levels of these proteins increased when low-autophagy melanoma cells were treated with the autophagy-inducing tat-BECN1 (Beclin 1) peptide and decreased when ATG7 (autophagy-related 7) was silenced in high-autophagy cells, thereby supporting a mechanistic link between these secreted proteins and autophagy. In addition, serum from metastatic melanoma patients with high tumor autophagy levels exhibited higher levels of these proteins than serum from patients with low-autophagy tumors. These results suggest that autophagy-related secretion affects the tumor microenvironment and measurement of autophagy-associated secreted proteins in plasma and possibly in tumors can serve as surrogates for intracellular autophagy dynamics in tumor cells.
Energy as information and constrained endogenous RNA interfence
Creators: name: Kohl, James V
Publisher: name: figshare
Year: 2017
Subjects: subject: 60806 Animal Physiological Ecology
subject: FOS: Biological sciences
subject: 60601 Animal Physiology - Biophysics
subject: 60802 Animal Cell and Molecular Biology
subject: 60803 Animal Developmental and Reproductive Biology

description: Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy.

The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection.

This detailed representation of energy-dependent natural selection for codon optimality links biologically- based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA. Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA. Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes.

For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution. The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes
Scalable Bayesian Model Averaging Through Local Information Propagation
Creators: name: Ma, Li
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Information and Computing Sciences
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Earth and Environmental Sciences
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences

description: This article shows that a probabilistic version of the classical forward-stepwise variable inclusion procedure can serve as a general data-augmentation scheme for model space distributions in (generalized) linear models. This latent variable representation takes the form of a Markov process, thereby allowing information propagation algorithms to be applied for sampling from model space posteriors. In particular, We propose a sequential Monte Carlo method for achieving effective unbiased Bayesian model averaging in high-dimensional problems, using proposal distributions constructed using local information propagation. The method—called LIPS for local information propagation based sampling—is illustrated using real and simulated examples with dimensionality ranging from 15 to 1000, and its performance in estimating posterior inclusion probabilities and in out-of-sample prediction is compared to those of several other methods—namely, MCMC, BAS, iBMA, and LASSO. In addition, it is shown that the latent variable representation can also serve as a modeling tool for specifying model space priors that account for knowledge regarding model complexity and conditional inclusion relationships. Supplementary materials for this article are available online.
Additional file 1 of Protein acetylation in mitochondria plays critical functions in the pathogenesis of fatty liver disease
Creators: name: Le-tian, Zhang
name: Cheng-zhang, Hu
name: Xuan, Zhang
name: Zhang, Qin
name: Zhen-gui, Yan
name: Qing-qing, Wei
name: Sheng-xuan, Wang
name: Zhong-jin, Xu
name: Ran-ran, Li
name: Ting-jun, Liu
name: Zhong-qu, Su
name: Zhong-hua, Wang
name: Ke-rong, Shi
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: Additional file 1: Fig. S1. Data reliability testing. Fig. S2. Gene Ontology (GO) functional annotation of differentially acttylated proteins at lysines. Fig. S3. Identification of highly enriched protein-protein interaction clusters.
Scalable Bayesian model averaging through local information propagation
Creators: name: Ma, Li
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Information and Computing Sciences
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Earth and Environmental Sciences
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences

description: We show that a probabilistic version of the classical forward-stepwise variable inclusion procedure can serve as a general data-augmentation scheme for model space distributions in (generalized) linear models. This latent variable representation takes the form of a Markov process, thereby allowing information propagation algorithms to be applied for sampling from model space posteriors. In particular, we propose a sequential Monte Carlo method for achieving effective unbiased Bayesian model averaging in high-dimensional problems, utilizing proposal distributions constructed using local information propagation. We illustrate our method—called LIPS for local information propagation based sampling—through real and simulated examples with dimensionality ranging from 15 to 1,000, and compare its performance in estimating posterior inclusion probabilities and in out-of-sample prediction to those of several other methods—namely, MCMC, BAS, iBMA, and LASSO. In addition, we show that the latent variable representation can also serve as a modeling tool for specifying model space priors that account for knowledge regarding model complexity and conditional inclusion relationships.
Mixed-refrigerant cooled 10 kA current leads for superconducting applications
Creators: name: Arnsberg, Jonas
name: Boehm, Friederike
name: Grohmann, Steffen
Publisher: name: Karlsruher Institut für Technologie (KIT)
Year: 2024

description: Current leads for superconducting magnets or power cables contribute significantly to the cryogenic heat load of the otherwise well isolated system. The thermodynamic optimization of current leads requires cooling not only at the cold end, but along their entire length. For larger scale systems, cooling with boil-off nitrogen or helium gas is well established. For compact or stand-alone applications, however, a liquid nitrogen or liquid helium infrastructure is usually not available to realize a closed-cycle cooling system with vapor-cooled current leads.

For the latter applications, a novel type of cryogenic mixed-refrigerant cooled current leads (CMRC-CC) offer a highly compact and efficient closed-cycle solution. In this case, the current leads fulfil both their electrical, as well as the thermal purpose as internal heat exchangers in a Linde-Hampson cycle operated with a wide-boiling refrigerant mixture. We present the prototype design of such 10 kA micro-structured current leads, which will be tested in our new test facility COMPASS. The paper gives an overview on the design process and presents the results of numerical studies on the current lead design and operation in different load scenarios.
Los fragmentos de la "Consueta-Ordinario Episcopal" Frag. 20-10 del Archivo Archidiocesano de Tarragona
Creators: name: Gros, Miquel S.
Publisher: name: Didaskalia
Year: 1995

description: Didaskalia, v. 25 n. 1-2 (1995): Número espercial de homenagem ao Prof. Joaquim O. Bragança em sua jubilação
A teologia como memória crítico-profética na era da globalização
Creators: name: Farias, José Jacinto Ferreira De
Publisher: name: Didaskalia
Year: 1999

description: Didaskalia, v. 29 n. 1-2 (1999): In Honorem D. José Policarpo: Patriarca de Lisboa e Magno Chanceler da Universidade Católica Portuguesa
Aluminum treatments to control internal phosphorus loading in lakes on Cape Cod, Massachusetts
Creators: name: Wagner, Kenneth J.
name: Meringolo, Dominic
name: Mitchell, David F.
name: Moran, Elizabeth
name: Spence Smith
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Inorganic Chemistry

description: Wagner KJ, Meringolo D, Mitchell DF, Moran E, Smith S. 2017. Aluminum treatments to control internal phosphorus loading in lakes on Cape Cod, Massachusetts. Lake Reserv Manage. 33:171–186. Ten lakes on Cape Cod, Massachusetts have been treated with aluminum since 1995, with 2 of those lakes receiving a second treatment. Elimination of cyanobacterial blooms was the goal in each case. Cape Cod lakes are mostly kettleholes with long detention times. Precipitation and groundwater dominated hydrologic inputs, but internal load contributed a major portion of the total phosphorus (TP) load to treated lakes. Aluminum sulfate and sodium aluminate were used in treatments with the intent to maintain a near-neutral pH in low alkalinity waters. Aluminum doses ranged from 10 to 100 g/m2, depending on mobile P concentrations in the upper 10 cm of sediment. Results varied, although all treatments lowered TP, provided relief from blooms, increased water clarity, and reduced oxygen demand for multiple years. Important lessons learned over 2 decades include how to apply aluminum to prevent fish mortality, options for dose calculation, and expectations for duration of benefits. To control internal loading and minimize cyanobacterial blooms at the lowest cost, treatment of Cape Cod lakes should apply aluminum at a concentration at least 10 times the mobile P concentration in the upper 10 cm of sediment exposed to anoxia and at concentrations that leave no more than 100 mg/kg of iron-bound P in laboratory inactivation assays. Cost of treatment in 2016 dollars averaged $150/g/m2 of applied aluminum per ha treated. Aluminum treatment has been demonstrated as a valued lake management tool to improve water quality and reduce nuisance algal blooms in Cape Cod lakes.
Production of neutral molecular clusters by controlled neutralization of mobility standards
Creators: name: G. Steiner
name: A. Franchin
name: J. Kangasluoma
name: V.-M. Kerminen
name: M. Kulmala
name: T. Petäjä
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cancer

description: Measuring aerosols and molecular clusters below the 3 nm size limit is essential to increase our understanding of new particle formation. Instruments for the detection of sub-3 nm aerosols and clusters exist and need to be carefully calibrated and characterized. So far calibrations and laboratory tests have been carried out using mainly electrically charged aerosols, as they are easier to handle experimentally. However, the charging state of the cluster is an important variable to take into account. Furthermore, instrument characterization performed with charged aerosols could be biased, preventing a correct interpretation of data when electrically neutral sub-3 nm aerosols are involved. This article presents the first steps to generate electrically neutral molecular clusters as standards for calibration. We show two methods: One based on the neutralization of well-known molecular clusters (mobility standards) by ions generated in a switchable aerosol neutralizer. The second is based on the controlled neutralization of mobility standards with mobility standards of opposite polarity in a recombination cell. We highlight the challenges of these two techniques and, where possible, point out solutions. In addition, we give an outlook on the next steps toward generating well-defined neutral molecular clusters with a known chemical composition and concentration. Published with license by American Association for Aerosol Research
Additional file 3 of Protein acetylation in mitochondria plays critical functions in the pathogenesis of fatty liver disease
Creators: name: Le-tian, Zhang
name: Cheng-zhang, Hu
name: Xuan, Zhang
name: Zhang, Qin
name: Zhen-gui, Yan
name: Qing-qing, Wei
name: Sheng-xuan, Wang
name: Zhong-jin, Xu
name: Ran-ran, Li
name: Ting-jun, Liu
name: Zhong-qu, Su
name: Zhong-hua, Wang
name: Ke-rong, Shi
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: Additional file 3: Table S2. Production information of normal (Norm) and fatty liver dairy cows that were liver biopsied and their serum biochemical parameters 1.