cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Pyridine activation
title: strategies for carbon-carbon bond formation on heterocyclic scaffolds
titleType: Subtitle
Creators: name: Shivers, Grant N.
Publisher: name: University of Iowa
Year: 2022
Subjects: Activation
Heterocycles
Methodology
Pyridines
Synthesis
public abstract

description: Aza heterocycles are ubiquitous structures in active pharmaceutical ingredients, natural products, and materials chemistry. Despite their importance, major synthetic challenges persist when manipulating such compounds. The objective of the work contained in this thesis was to develop new carbon-carbon bond forming reactions on aza heterocylic scaffolds. Specifically, development of new strategies to achieve pyridine activation resulted in three new types of transformations suitable for functionalizing simple pyridine substrates.An improved preparation of N-alkenyl-2-pyridones was achieved starting from 2-halopyridinium salts. This transformation circumvents the issue of mixed N- and O- alkylation encountered in established pyridone reactions and allows for milder reaction conditions than other reported manipulations of pyridone ring systems. Several different aldehydes and 2-halopyridine derivatives successfully gave the reaction, and the N-alkenyl pyridone products are amenable to further elaboration as demonstrated in several examples.
description: Moreover, 4-alkenyl pyridines were prepared through a homologation sequence between activated 4-alkyl pyridines and an electrophilic methylene source. These exceedingly simple and mild reaction conditions enable a unique alkenylation strategy that minimizes functional group demands required for alternative preparations of geminally disubstituted alkenyl pyridines.
description: Furthermore, allylated 4- and 2-alkyl pyridines were successfully prepared from N-allyl pyridinium salts in the presence of palladium catalysts. This reaction demonstrated efficacy for both 2- and 4-alkyl pyridines, and important reaction parameters influencing the success of this allylation strategy were identified.
A testing metric for designs modelled as hierarchical finite-state machines.
Creators: name: Lew, Ning.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Computer Science.

description: Modern software design tools use finite-state machines (FSMs) arranged in hierarchical fashion. Many techniques have been developed for testing software modelled as an FSM, but none explicitly addressing designs modelled as a hierarchical FSM (HFSM). Additionally, the problem of explosion in the number of test paths precludes the testing of all possible paths through the HFSM [Holzmann 91]. This thesis presents a practical and scalable method for testing a design modelled as an HFSM. The method is based on graph traversal and uses the hierarchy of the underlying directed graph. A recursive algorithm computes breadth, the number of paths needed just to cover all transitions at least once. This idea is extended to cover all states, all inputs, and all outputs. This method is complementary to existing formal methods for conformance testing and protocol testing. Breadth is a lower bound on the number of test paths to cover the HFSM.
Oral microbiome and metabolome in fixed orthodontic therapy
Creators: name: Bhagat, Ronak J
Publisher: name: University of Iowa
Year: 2026
Subjects: Fixed Orthodontics
Oral Microbiome
Orthodontic therapy
Periodontal disease
Subgingival Plaque
Metabolites

description: BACKGROUND
description: With orthodontics gaining popularity for enhancing esthetics and function, approximately 4.5 million Americans, predominantly aged 6 to 18, wear braces. Yet, fixed orthodontic therapy (FOT) poses challenges to oral hygiene, leading to increased plaque, heightened risks of caries, gingivitis, periodontitis, and common complications such as gingival inflammation and elevated periodontal pathogens during orthodontic treatment. Furthermore, orthodontic tooth movement involves a complex tissue remodeling process which are all intricately linked with immune cells and immunologically active substances. We aim to comprehensively evaluate the oral microbiome, inflammatory mediators, and metabolites from subgingival plaque samples in patients undergoing FOT at various time points during treatment.
description: METHODS
description: 55 orthodontic patients and 14 periodontally healthy control subjects participated in this cross-sectional analysis. These patients ranged in age from 11-20 years and were matched for age, gender, and dentition. Subgingival plaque samples and GCF (Gingival Crevicular Fluid) were collected at 6 months, 12 months, or 24 months (about 2 years)/deband in orthodontic therapy. DNA isolation was performed using the Qigen DNEasy kit for plaque samples. 16S rRNA sequencing was performed with Illumina MiSeq platform. Analyses were conducted with DADA2, QIIME2. Taxonomy identification was determined against the HOMD (Human Oral Microbial Database) database. Alpha and beta-diversity were assessed. Metabolomic data was assessed via gas chromatography/mass spectrometry (GC/MS) analyses. A MILLIPLEX® Multiplex for Luminex® Immunoassay (Millipore, Sigma Aldrich) was used for cytokine and immune mediator analysis.
description: RESULTS
description: Patients undergoing FOT had a significantly distinct bacterial composition compared to controls. The microbiome of FOT was associated with an increase in several caries and inflammation associated species such as Saccharibacteria, Treponema, Prevotella, and Streptococcus species. Changes in the oral microbiome were most significant during earlier time points of treatment. Many of the metabolites identified in the study could be grouped into one of three categories: inflammation, collagen metabolism, and bone homeostasis, all of which are significant processes during orthodontic therapy. Analysis of the immune mediators revealed there were elevated levels of pro-inflammatory mediators like INF-y, IL-22, IL-1B, and IL-7 at 6 months while IL-10 was decreased throughout all time points in FOT.
description: CONCLUSION
description: Our integrated -omics approach is the first step towards understanding the comprehensive interdependent roles of oral microbiota, the host response, and metabolites associated in the subgingival environment of patients undergoing FOT.
Use of vitamin K antagonists for secondary stroke prevention depends on the treating healthcare provider in Germany – results from the German AFNET registry
Creators: name: Haeusler, Karl Georg
name: Gerth, Andrea
name: Limbourg, Tobias
name: Tebbe, Ulrich
name: Oeff, Michael
name: Wegscheider, Karl
name: Treszl, András
name: Ravens, Ursula
name: Meinertz, Thomas
name: Kirchhof, Paulus
name: Breithardt, Günter
name: Steinbeck, Gerhard
name: Nabauer, Michael
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: Atrial fibrillation
subject: Ischaemic stroke
subject: Secondary stroke prevention
subject: German AFNET registry
subject: Anticoagulants
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Anticoagulation using vitamin K antagonists (VKAs) significantly reduces the risk of recurrent stroke in stroke patients with atrial fibrillation (AF) and is recommended by guidelines. Methods The German Competence NETwork on Atrial Fibrillation established a nationwide prospective registry including 9,574 AF patients, providing the opportunity to analyse AF management according to German healthcare providers. Results On enrolment, 896 (9.4 %) patients reported a prior ischaemic stroke or transient ischaemic attack. Stroke patients were significantly older, more likely to be female, had a higher rate of cardiovascular risk factors, and more frequently received anticoagulation (almost exclusively VKA) than patients without prior stroke history. Following enrolment, 76.4 % of all stroke patients without VKA contraindications received anticoagulation, which inversely associated with age (OR 0.95 per year; 95 % CI 0.92–0.97). General practitioners/internists (OR 0.40; 95 % CI 0.21–0.77) and physicians working in regional hospitals (OR 0.47; 95 % CI 0.29–0.77) prescribed anticoagulation for secondary stroke prevention less frequently than physicians working at university hospitals (reference) and office-based cardiologists (OR 1.40; 95 % CI 0.76–2.60). The impact of the treating healthcare provider was less evident in registry patients without prior stroke. Conclusions In the AFNET registry, anticoagulation for secondary stroke prevention was prescribed in roughly three-quarters of AF patients, a significantly higher rate than in primary prevention. We identified two factors associated with withholding oral anticoagulation in stroke survivors, namely higher age and—most prominently—treatment by a general practitioner/internist or physicians working at regional hospitals.
Three essays on low-price guarantees
Creators: name: Zhang, Liping
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Business Administration, Marketing.
subject: Economics, General.

description: This thesis consists of three essays and one literature review. The thesis examines theoretically the effects of Low-Price Guarantees (LPGs), which are increasingly common in retail markets and goods industries. Although the essays in this thesis share a common theme, they can be read independently without impeding the readers' understanding of the issues discussed in each. The first essay studies the effects of LPGs in the search model of Salop and Stiglitz (1977). This model provides a general framework for the comparison of Matching Competition Clauses (MCCs) and Beating Competition Clauses (BCCs): The number of firms in the market is determined by free entry and consumers have incomplete information about prices and differ in their search costs. It is shown that MCCs have stronger collusive effects than BCCs, however, these effects evaporate with the introduction of an arbitrarily small hassle cost. The second essay extends the Milgrom and Robers model (1982) to study the entry deterrence effects of LPGs. In this model, the potential entrant has no complete information about the true unit cost of the incumbent. It is demonstrated that under certain conditions, the high-cost incumbent can imitate the behavior of the low-cost one and deter entry even in situations where this would not be possible in the absence of a price guarantee. Therefore, the corresponding policy suggestion is to prohibit this pricing behavior when it is exerted by a monopolist. The third essay studies LPGs in a partial equilibrium model, where consumers can search for lower prices but search takes time and thus delays consumption. A price guarantee to match any lower price offered by the retailer allows a consumer to purchase and consume now while keeping the option of reaping the benefit of a lower price that he may find later in time. The analysis demonstrates how the following two factors, the variability of market prices and the percentage of bargain hunters, affect the decisions that a firm needs to make in setting its price and the duration of its price guarantee in a competitive environment.
Comparison of a New Multiplex Immunoassay for Measurement of Ferritin, Soluble Transferrin Receptor, Retinol-Binding Protein, C-Reactive Protein and α1-Acid-glycoprotein Concentrations against a Widely-Used s-ELISA Method
Creators: name: Karakochuk, Crystal D.
name: Henderson, Amanda M.
name: Samson, Kaitlyn L. I.
name: Aljaadi, Abeer M.
name: Devlin, Angela M.
name: Becquey, Elodie
name: Wirth, James P.
name: Rohner, Fabian
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Recently, a multiplex ELISA (Quansys Biosciences) was developed that measures ferritin, soluble transferrin receptor (sTfR), retinol-binding protein (RBP), C-reactive protein (CRP), α1-acid glycoprotein (AGP), thyroglobulin, and histidine-rich protein 2. Our primary aim was to conduct a method-comparison study to compare five biomarkers (ferritin, sTfR, RBP, CRP, and AGP) measured with the Quansys assay and a widely-used s-ELISA (VitMin Lab, Willstaett, Germany) with use of serum samples from 180 women and children from Burkina Faso, Cambodia, and Malaysia. Bias and concordance were used to describe the agreement in values measured by the two methods. We observed poor overall agreement between the methods, both with regard to biomarker concentrations and deficiency prevalence estimates. Several measurements were outside of the limit of detection with use of the Quansys ELISA (total n = 42 for ferritin, n = 2 for sTfR, n = 0 for AGP, n = 5 for CRP, n = 22 for RBP), limiting our ability to interpret assay findings. Although the Quansys ELISA has great potential to simplify laboratory analysis of key nutritional and inflammation biomarkers, there are some weaknesses in the procedures. Overall, we found poor comparability of results between methods. Besides addressing procedural issues, additional validation of the Quansys against a gold standard method is warranted for future research.
Connexin32-mediated control of progenitor cell fate in injured and uninjured adult mouse brain
Creators: name: Melanson-Drapeau, Lysanne
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Biology, Neuroscience.

description: Gap junction protein expression has been implicated in progenitor cell proliferation, survival, and specification during development. The present study was undertaken to establish the role of the gap junction protein connexin32 in dictating progenitor cell fate in adult mouse brain. In the dentate gyrus of the hippocampus, I localized the connexin32 protein to a subset of NG2 + early oligodendrocyte progenitors. In connexin32-null mutant mice, I found an increase in the total number of proliferating early oligodendrocyte progenitors and demonstrated that the turnover of these cells is constitutively enhanced (Chapter 2). Furthermore, behavioural testing in a learning and memory task revealed that connexin32-deficient mice exhibit impaired reference memory, indicating that progenitor cells may play a role in hippocampal associated cognitive function (Chapter 3). In vitro analysis further demonstrated that these progenitors are able to differentiate into neurons upon a neurogenic stimulus. In Chapter 4, I assessed the ability of hippocampal progenitors to activate and regenerate brain tissue in vivo, following kainic acid-induced epileptiform seizures, in the presence or absence of connexin32. I show that connexin32-null mutation promotes more effective neurogenesis from NG2+ progenitor cells activated in the CA3a/b pyramidal zone, following excitotoxic injury. To confirm the role of connexin32 in determining progenitor cell fate, I performed a series of gain of function studies by inducing ectopic connexin32 expression in neurosphere progenitor cultures (Chapter 5). I show that connexin32 promotes oligodendrogenesis in vitro, at the expense of neurogenesis. These experiments provide insight into connexin-mediated control of neural progenitor specification and begin to identify connexins as possible therapeutic targets following brain injury.
Thermal and optical properties of sol-gel and SU-8 resists
Creators: name: Suzuki, Toshiyuki
name: Morikaw, Junko
name: Hashimoto, Toshimasa
name: Buividas, Richard
name: Gervinskas, Gediminas
name: Paipulas, Domas
name: Malinauskas, Mangirdas
name: Mizeikis, Vygantas
name: Juodkazis, Saulius
name: Schoenfeld, Winston V.
name: Rumpf, Raymond C.
name: von Freymann, Georg
Publisher: name: Swinburne
Year: 2024

description: We report on a combined differential scanning calorimetric (DSC) and Raman scattering study of thermal polymerization of sol-gel organic-inorganic SZ2080 and SU-8 resists. In SZ2080, endothermic peak at 95°C signify drying of the resist and justifies the required pre-bake at around 100°C for 1-2 h for the best performance during femtosecond (fs-)direct laser writing. A strong exothermic peak at 140°C (under 2 K/min heating rate) completes polymerization of the resist. It is revealed that 1wt% of photoinitiators change Raman scattering intensity of SZ2080 and can contribute efficiently to heating and cross-linking of photo-polymers. In the case of SU-8, a 65°C DSC feature related to solvent evaporation was observed. The strongest changes in Raman spectrum occurs at a narrow 895 cm-1 band which is linked to polymerization. Raman scattering taken during DSC revealed spectral changes following the polymerization; an applicability of this method for monitoring photopolymerization induced by ultra-fast laser sources and feasibility of a laser-modulated calorimetry is discussed.
title: Das Heilige Grab in Konstanz
title: Technologische Untersuchung in Hinblick auf seine kunsthistorische Einordnung
titleType: Subtitle
Creators: name: Bussmann, Stephan
Publisher: name: Fachhochschule Köln
Year: 2001
Subjects: Conservation/ArtHistory

description: Das steinerne Heilige Grab in Konstanz reiht sich ein unter die bedeutesten Kunstdenkmäler der deutschen Frühgotik. Bis heute gibt es mangels Quellen viele Spekulationen über die Enstehungszeit, die Erbauer, sowie die ursprüngliche Funktion. Mitte der 60iger Jahre wurde der Bau relativ zurückhaltend restauriert und auf den heutigen Zustand freigelegt. Die damals gewonnenen Erkenntnisse erscheinen aus heutiger Sicht jedoch sehr widersprüchlich und ungesichert. Durch eine restauratorische Bestandsuntersuchung mit besonderer Berücksichtigung der Fassung, wird versucht neue Ansätze für die Kunstwissenschaft zu erarbeiten, sowie allgemein die bis heute sehr lückenhaften Kenntnisse über mittelalterliche Steinskulpturen anhand eines prominenten Beispieles des 13. Jahrhunderts zu erweitern.
Study of magnetic field effects on radical reactions and of the mobility of transients in microheterogeneous systems.
Creators: name: Mohtat, Nadereh.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Biology, Animal Physiology.

description: This thesis involves laser flash photolysis studies of the kinetic behaviour of photochemical reactions in heterogeneous media with the emphasis on the effects of magnetic fields on the reactions involving triplet radical pairs. Chapters 3 and 4 present results of the effects of magnetic fields on the behaviour of radical pairs in organized systems. Free radicals are known to be involved in many biological processes and are thought to be a major initiator of some types of cancer. As a result, we have determined how free radical behaviour is modified in the presence of a 60 Hz oscillating magnetic field superimposed over a static magnetic field of comparable magnitude. We showed that the effect of an oscillating magnetic field on radical behaviour is identical to that exerted by a static magnetic field of the same strength provided the frequency is low in comparison with radical pair dynamics. We have used a test system involving radical pairs generated in micellar solutions by photolysis of benzophenone in the presence of 1,4-cyclohexadiene. Our results show that radical pair reactions in micellar solutions exhibit the same behaviour under 60 Hz oscillating fields as under static field conditions at any point in time. Given that (a) radicals play an important role in metabolic processes, and (b) that radical behaviour is strongly influenced by magnetic fields, it was clearly necessary to undertake experiments that better mimic in vivo systems. Laser flash photolysis of probe molecules, such as benzophenone and some of its derivatives, leads to a triplet spin-correlated radical pair due to the hydrogen abstraction of the triplet from Bovine and/or Human Serum Albumin. The analysis of the kinetics of the radical pair, where one of them is derived from the protein, in the presence and in the absence of a magnetic field, shows that the protein-probe radical pair is subject to a magnetic field effect. In Chapter 5, the photophysical properties of microheterogeneous systems have been characterized using the triplet state of an appropriate probe. (Abstract shortened by UMI.)
title: Ressourcenschutz durch Stadtplanung und Stadtentwicklung
title: Ressourcenschutz durch Stadtplanung und Stadtentwicklung
titleType: AlternativeTitle
Creators: name: Verbücheln, Maic
name: Buchert, Matthias
name: Bleher, Daniel
Publisher: name: Umweltbundesamt
Year: 2021
Subjects: subject: Stadtplanung
subject: Stadtentwicklung
subject: Ressourcenerhaltung
subject: Ressourcenschutz
subject: Abfall | Ressourcen

description: Städte und ihr Umland sind "Hot-Spots" der Ressourceninanspruchnahme. Gebäude und Infrastrukturen verursachen beispielsweise in der Bau- und Nutzungsphase einem hohen Bedarf an Rohstoffen, Energie, Fläche und Wasser, was negative Umwelteffekte verursacht. Stadtplanung und -entwicklung können wichtige Beiträge leisten die Ressourceninanspruchnahme zu reduzieren, da sie direkten Einfluss auf Bautätigkeiten und die Infrastrukturversorgung haben. Dieses Hintergrundpapier formuliert Empfehlungen an die Bundes- und Landesebene zur Stärkung des Ressourcenschutzes in Stadtplanung und -entwicklung. Im Fokus stehen Möglichkeiten durch Gesetze, Verordnungen, Strategien und Fördermechanismen. Quelle: https://www.umweltbundesamt.de
description: Städte und ihr Umland sind „Hot-Spots“ der Ressourceninanspruchnahme. Gebäude und Infrastrukturen verursachen beispielsweise in der Bau- und Nutzungsphase einem hohen Bedarf an Rohstoffen, Energie, Fläche und Wasser, was negative Umwelteffekte verursacht. Stadtplanung und -entwicklung können wichtige Beiträge leisten die Ressourceninanspruchnahme zu reduzieren, da sie direkten Einfluss auf Bautätigkeiten und die Infrastrukturversorgung haben. Dieses Hintergrundpapier formuliert Empfehlungen an die Bundes- und Landesebene zur Stärkung des Ressourcenschutzes in Stadtplanung und -entwicklung. Im Fokus stehen Möglichkeiten durch Gesetze, Verordnungen, Strategien und Fördermechanismen.
Physical optics analysis of electrically small slot-fed substrate lens antennas.
Creators: name: Bray, Joey R.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Engineering, Electronics and Electrical.

description: With the current explosion of microwave wireless communication systems comes the need to produce low cost miniaturized components. Integrated antennas, such as planar microstrip-fed patches and slots, are a promising means of combining the antenna function with the associated transceiver circuitry. However, these antennas suffer from a bi-directional radiation pattern, power loss via substrate modes, a broad radiation pattern, or a combination of the above. To correct these problems, a dielectric lens of hemispherical shape, or slight variation thereof, can be placed directly upon the planar antenna, forming what is called a Substrate Lens Antenna (SLA). At sub-millimeter-wave frequencies, a SLA becomes unattractive because its diameter is typically larger than a free-space wavelength. Such lenses become heavy, bulky and expensive as the operating frequency is reduced. This thesis investigates electrically small, slot antenna fed, SLAs operating at 10 GHz in an attempt to facilitate the integration of these devices. (Abstract shortened by UMI.)
Decontamination of zinc-polluted kaolinite with electrokinetic process.
Creators: name: Shariatmadari, Nader.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Agriculture, Soil Science.

description: Electrokinetic treatment is a promising technology to remove contaminants from clayey soils. The interaction of various processes that take place simultaneously is yet to be understood, in order to better predict the efficiency of the process in a variety of soil-contaminant situations. The electrokinetic process refers to movement of water, ions, and charged particles relative to one another under the action of an applied direct current electrical field. In this research electrokinetic experiments are conducted on saturated kaolinite specimens loaded with zinc to investigate the efficiency of contaminant removal and energy expenditure during the treatment. The effect of various electrical fields on electrokinetic remediation was studied by application of constant electrical potential and current with different intensities across the specimens. The treatment duration in various tests ranged from 3 to 73 days. Electroosmotic flow, electrical gradient variation, pH, conductivity, and zinc concentration of the anolyte, catholyte and pore solution across the specimen, were measured. The calculated electroosmotic coefficients of permeability (k$\sb{\rm e}$) were within range of literature values but were not constant over time. The migration of zinc within the soil from the anode toward the cathode was significant. Almost all transported zinc was accumulated in a thin layer of soil near the cathode chamber due to high pH environment. Formation of this low conductivity layer results in higher potential drop in this region and increase in energy expenditure. In order to reduce the amount of precipitation and increase the removal of zinc in to the cathode chamber, pH enhancement technique with application of acetic acid was employed. Neutralizing the pH in the cathode chamber (pH = 6) did not lead to increase in removal efficiency of heavy metal. However, controlling the pH at lower level (pH = 4) at the cathode compartment was successful for removal of 60% zinc from soil. Effect of the position of the reference electrode on energy consumption was also studied. Experiments under controlled electrical potential field, with positioning the reference electrode close to the cathode, indicated reasonable reduction of energy expenditure during the treatment. The principal conclusions were as follows: (1) The electrokinetic technique is effective and economical for short term remediation. (2) The constant potential electrical field demonstrated lower energy consumption compared to the constant current condition, both in short term and long term remediation. (3) Controlling the pH to a value less than 4 in the cathode compartment, successfully flushed the zinc out of the sample to the catholyte. (4) Placement of the reference electrode close to the cathode (working) electrode, decreased the amount of energy expenditure significantly.
Herb-Induced Liver Injury in the Berlin Case-Control Surveillance Study
Creators: name: Douros, Antonios
name: Bronder, Elisabeth
name: Andersohn, Frank
name: Klimpel, Andreas
name: Kreutz, Reinhold
name: Garbe, Edeltraut
name: Bolbrinker, Juliane
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: hepatotoxicity
subject: phytotherapeutics
subject: pharmacovigilance
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik

description: Herb-induced liver injury (HILI) has recently attracted attention due to increasing reports of hepatotoxicity associated with use of phytotherapeutics. Here, we present data on HILI from the Berlin Case-Control Surveillance Study. The study was initiated in 2000 to investigate the serious toxicity of drugs including herbal medicines. Potential cases of liver injury were ascertained in more than 180 Departments of all 51 Berlin hospitals from October 2002 to December 2011. Drug or herb intake was assessed through a standardized face- to-face interview. Drug or herbal aetiology was assessed based on the updated Council for International Organizations of Medical Sciences scale. In ten of all 198 cases of hepatotoxicity included in the study, herbal aetiology was assessed as probable (once ayurvedic herb) or possible (Valeriana five times, Mentha piperita once, Pelargonium sidoides once, Hypericum perforatum once, Eucalyptus globulus once). Mean age was 56.4 ± 9.7 years, and the predominant pattern of liver injury was hepatocellular. No cases of acute liver failure or death were observed. This case series corroborates known risks for ayurvedic herbs, supports the suspected association between Valeriana use and liver injury, and indicates a hepatotoxic potential for herbs such as Pelargonium sidoides, Hypericum perforatum or Mentha piperita that were rarely associated with liver injury before. However, given that possible causality does not prove clinical significance, further studies in this field are needed.
Molecular regulation of neuronal apoptosis in PC12 cells.
Creators: name: Sridhar, Srikala.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Biology, Molecular.

description: In this study apoptosis was induced in neuronal PC12 cells by 2-5 $\mu$M VM26 (teniposide, a known apoptotic inducer) and changes in the expression of genes considered to be involved in apoptosis were examined by RT-PCR. Cell death, DNA fragmentation and morphological changes associated with apoptosis were evident within 8 hours after exposure to VM26 indicating that VM26 is capable of inducing apoptosis. Within 8 hours of VM26 exposure, clusterin (TRPM-2) and IGFBP2 (Insulin-like growth factor binding protein 2) were both upregulated by 3 and 4 fold respectively. Cathepsin B (RSG-2) and RSG-3 (embigin) exhibited marginal changes in expression, only about 1.2 fold, over the 24 hour time course. Finally, IGFBP5 (Insulin-like growth factor binding protein 5) displayed a substantial decrease in expression, with a 4 fold decrease compared to control. Since IGFBPs appear to play a role in apoptosis, the effects of IGF-I treatment on cells undergoing apoptosis was examined. Treatment with IGF-I led to a dose-dependent protective effect on apoptosis induced by VM26. In the presence of 200 ng/ml IGF-I, cell viability was 52.1% at 24 hours compared to non-treated cells, at 35.8% viability. In addition, IGF-I was able to modulate cell viability, in a manner that did not involve induction of proliferation as assessed by cell counts in IGF-I treated and untreated PC12 cells. (Abstract shortened by UMI.)
3639739.pdf
Creators: name: DeVault, Clayton
name: Zenin, Vladimir
name: Pors, Anders
name: Chaudhuri, Krishnakali
name: Kim, Jongbum
name: Boltasseva, Alexandra
name: Shalaev, Vladimir
name: Bozhevolnyi, Sergey
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary 1
Life-cycle assessment of transportation biofuels from hydrothermal liquefaction of forest residues in British Columbia
Creators: name: Nie, Yuhao
name: Bi, Xiaotao
Publisher: name: BioMed Central
Year: 2018

description: Background: Biofuels from hydrothermal liquefaction (HTL) of abundantly available forest residues in British Columbia (BC) can potentially make great contributions to reduce the greenhouse gas (GHG) emissions from the transportation sector. A life-cycle assessment was conducted to quantify the GHG emissions of a hypothetic 100 million liters per year HTL biofuel system in the Coast Region of BC. Three scenarios were defined and investigated, namely, supply of bulky forest residues for conversion in a central integrated refinery (Fr-CIR), HTL of forest residues to bio-oil in distributed biorefineries and subsequent upgrading in a central oil refinery (Bo-DBR), and densification of forest residues in distributed pellet plants and conversion in a central integrated refinery (Wp-CIR). Results: The life-cycle GHG emissions of HTL biofuels is 20.5, 17.0, and 19.5 g CO2-eq/MJ for Fr-CIR, Bo-DBR, and Wp-CIR scenarios, respectively, corresponding to 78–82% reduction compared with petroleum fuels. The conversion stage dominates the total GHG emissions, making up more than 50%. The process emitting most GHGs over the life cycle of HTL biofuels is HTL buffer production. Transportation emission, accounting for 25% of Fr-CIR, can be lowered by 83% if forest residues are converted to bio-oil before transportation. When the credit from biochar applied for soil amendment is considered, a further reduction of 6.8 g CO2-eq/MJ can be achieved. Conclusions: Converting forest residues to bio-oil and wood pellets before transportation can significantly lower the transportation emission and contribute to a considerable reduction of the life-cycle GHG emissions. Process performance parameters (e.g., HTL energy requirement and biofuel yield) and the location specific parameter (e.g., electricity mix) have significant influence on the GHG emissions of HTL biofuels. Besides, the recycling of the HTL buffer needs to be investigated to further improve the environmental performance of HTL biofuels.
Le caring comme indicateur en évaluation de la qualité des soins infirmiers en santé communautaire.
Creators: name: Blais, Jocelyne.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Health Sciences, Nursing.

description: En depit de l'urgence d'evaluer la qualite des soins infirmiers en sante communautaire, ce domaine de recherche demeure peu explore. L'evaluation de la qualite des soins infirmiers en sante communautaire exige un cadre de reference capable de tenir compte des realites inherentes a l'exercice infirmier communautaire. Dans un domaine ou les habiletes relationnelles ont preseance sur les habiletes techniques, le cadre de reference supportant l'evaluation doit faire une place preponderante a la relation infirmiitre-client. Dans ce contexte, le concept du caring, tel que definit par Watson, apparai t un indicateur pertinent de la qualite des soins infirmiers. S'appuyant sur la theorie de Watson, cette recherche descriptive a pour but d'identifier les comportements infirmiers qui sont percus par les clients en sante communautaire comme demontrant du caring. Pour ce faire, une liste de 98 items correspondants aux dix facteurs de caring fut elaboree. Des 684 clients francophones ayant recu des soins infirmiers a domicile dans un CLSC de l'Outaouais, 158 retournerent le questionnaire dament rempli. Les resultats obtenus permettent de determiner la valeur relative des comportements infinniers et des dix facteurs de caring, telle qu'attribuee par les repondants. Ainsi, les clients en sante communautaire placent en premiere priorite les comportements infirmiers qui sont empreints d'humanisme et qui temoignent de la competence relationnelle de l'infirmiere. Les resultats suggerent egalement l'existence de differences dans les perceptions selon les besoins de sante, l'age et le degre de scolarite des participants. Le concept de caring apparait un indicateur de qualite valable et devrait etre integre a un modele d'evaluation de la qualite en soins infirmiers en sante communautaire.
3639739.pdf
Creators: name: DeVault, Clayton
name: Zenin, Vladimir
name: Pors, Anders
name: Chaudhuri, Krishnakali
name: Kim, Jongbum
name: Boltasseva, Alexandra
name: Shalaev, Vladimir
name: Bozhevolnyi, Sergey
Publisher: name: Optica Publishing Group
Year: 2018
Subjects: Uncategorized

description: Supplementary 1
The influence of age of learning on syllable structure in the L2 speaker.
Creators: name: Boron, Anna M.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Language, Linguistics.

description: Age of Arrival (AOA) in the L2 community has been a factor in several L2 acquisition studies examining various phonological phenomena, such as consonant perception and vowel perception and production (e.g. Flege et al., 1995; Flege et al., 1997). The literature on phonological acquisition in L2 is not informative, however, on the question of syllable structure. This study addresses the issue of the degree to which syllable structure is subject to modification as a function of AOA. Subjects in the study were mature Italian speakers, whose L2 (English) phonology has presumably plateaued. They were divided into two groups based on their AOA in Canada (Early NI [arrival in Canada between the ages of 2 and 13] and Late NI [arrival in Canada between the ages of 15 and 26]). Italian differs from English in a number of ways. The legality constraints, such as permissible consonant phonemes and their combinations in coda position differ for the two languages. These constraints were examined in this study along-side the effect of stress. Stress, a language-particular constraint, was expected to affect syllabification of Native English (NE) speakers. Legality and stress were explored in a "word game", where subjects were asked to resyllabify bisyllabic nonsense words. (Abstract shortened by UMI.)
Antioxidant and Free Radical Scavenging Potential of Yakuchinone B Derivatives in Reduction of Lipofuscin Formation Using H2O2-Treated Neuroblastoma Cells
Creators: name: Samaneh Bayati
name: Yazdanparast, Razieh
Publisher: name: the Pasteur Institute of Iran
Year: 1996
Subjects: subject: Basic Sciences

description: Iranian Biomedical Journal (IBJ); ISSN 1028-852X
MERGING conventional and complementary medicine in a clinic department - a theoretical model and practical recommendations
Creators: name: Pérard, Marion
name: Mittring, Nadine
name: Schweiger, David
name: Kummer, Christopher
name: Witt, Claudia M.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: Merger
subject: Fusion
subject: Complementary medicine
subject: Health management
subject: Corporate culture
subject: Integrative medicine
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Today, the increasing demand for complementary medicine encourages health care providers to adapt and create integrative medicine departments or services within clinics. However, because of their differing philosophies, historical development, and settings, merging the partners (conventional and complementary medicine) is often difficult. It is necessary to understand the similarities and differences in both cultures to support a successful and sustainable integration. The aim of this project was to develop a theoretical model and practical steps that are based on theories from mergers in business to facilitate the implementation of an integrative medicine department. Methods Based on a literature search and expert discussions, the cultures were described and model domains were developed. These were applied to two case studies to develop the final model. Furthermore, a checklist with practical steps was devised. Results Conventional medicine and complementary medicine have developed different corporate cultures. The final model, which should help to foster integration by bridging between these cultures, is based on four overall aspects: culture, strategy, organizational tools and outcomes. Each culture is represented by three dimensions in the model: corporate philosophy (core and identity of the medicine and the clinic), patient (all characteristics of the professional team’s contact with the patient), and professional team (the characteristics of the interactions within the professional team). Conclusion Overall, corporate culture differs between conventional and complementary medicine; when planning the implementation of an integrative medicine department, the developed model and the checklist can support better integration.
Defining a Sustainable Development Target Space for 2030 and 2050
Creators: name: Vuuren, Detlef P. Van
name: Messner, Dirk
name: Zimm, Caroline
name: Busch, Sebastian
Publisher: name: My University
Year: 2021
Subjects: Modellierung

description: By adopting the Sustainable Development Goals (SDGs), countries worldwide agreed to an agenda for achieving a prosperous, socially inclusive and environmentally sustainable future for all1. This ambition, however, also exposes a critical knowledge gap since science-based insights on how to achieve the 17 SDGs simultaneously are lacking. Quantitative goal-seeking scenario studies could enable exploration of the systems' transformations required to achieve the SDGs, but this requires a clear definition of the "target space". The 169 targets and 232 indicators defined by the international community for monitoring SDG implementation cannot be directly used for this purpose. Here, we define a streamlined set of well defined, science-based indicators and associated target values that is quantifiable and actionable to make quantitative scenario analysis meaningful, relevant (i.e. reflecting societal goals), and yet simple enough to keep analysis transparent and communicable. The set of 36 targets is based on the UN 2030 Agenda, other existing multilateral agreements and insights from sustainability science and expert assessment, and it includes 2050 as an additional longer-term reference point. Thus, this target space provides a strategic focus to guide the scientific community in developing new global sustainable development pathways.
On the nature and function of scepticism in speculative philosophy: A study of G. W. F. Hegel's "Logic" and A. N. Whitehead's "Process and Reality".
Creators: name: Scarfe, Adam Christian.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Philosophy.

description: The following doctoral dissertation constitutes a conjoint analysis of the workings of scepticism as contained within Hegel's and Whitehead's respective and contrasting philosophies of 'process'. In it, I hypothesize that for these speculative thinkers, scepticism may be described as the 'mover' of philosophical, religious, and scientific endeavour. Part One of the thesis focuses on Hegel's 'initially-idealistic' standpoint of Absolute Idealism as contained in the Logic. I find that for him, scepticism is to be defined as the recognition and negation of finitude. Drawing from Hegel's general distinction of Ancient and Modern forms of scepticism, I argue that scepticism is representative of the moment of 'cancellation' implicit within the dialectical progression of the logical Concept (Begriff). Subsequently, I trace the role of scepticism as the recognition of finitude with respect to the unfolding of Hegel's criterion of truth characteristic of Absolute Idealism, namely, within the process by which the dialectical opposition of 'idealism' and 'realism' is worked out. Part Two concerns Whitehead's 'provisionally-realistic' philosophy of Organism as advanced in Process and Reality. I elucidate the fact that for him, scepticism is the main contributor to the problem of the radical 'bifiurcation' of actualities. Following from an elucidation of the interplay between his ontological principle and the principle of relativity, as well as an analysis of his three modes of perception, I propose that Whitehead's notions of the 'division' and 'decision' of the extensive continuum signify the workings of scepticism. In carrying out this interpretation, I show that 'negative prehensions' constitute the means by which the extensive continuum is divided by the organism, and are the efficient element in the creativity of organisms. And, I trace both the 'realistic' and 'idealistic' activities of 'negative prehensions' with respect to his descriptions of the unfolding of the creative processes of organisms. Part Three of the dissertation focuses directly on the ramifications of accepting my initial hypothesis that, in speculative philosophy, scepticism is described as the 'mover' of philosophical, scientific, and religious endeavour. I advance an overall synopsis of the nature and function of scepticism in, and in light of, my study of speculative philosophy. Lastly, I offer a critical response to the radical 'instrumental' scepticism predominant in our era, from both Hegelian and Whiteheadian perspectives.
3645377.pdf
Creators: name: Choi, Youngwoon
name: Hosseini, Poorya
name: Kang, Jeon Woong
name: Kang, Sungsam
name: Yang, Taeseok
name: Hyeon, Min Gyu
name: Kim, Beop-Min
name: So, Peter
name: Yaqoob, Zahid
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: This document provides supplementary information to "Reflection phase microscopy using spatio-temporal coherence of light".
Gas adsorption with molecular sieve zeolites.
Creators: name: Apolonatos, Georgia.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Engineering, Chemical.

description: Adsorption kinetics and equilibrium of CH$\sb4$, CO and N$\sb2$ gases were studied on various molecular sieve zeolites. Ethylyne was also tested, yet was found to be incompatible with the molecular sieves under consideration. The gas chromatographic technique was chosen as the method of studying the adsorption by which equilibrium and kinetic parameters are derived by matching the response peak to appropriate mathematical models. It was found that the synthetic zeolites (H-Mordenite, 4A zeolite, 5A zeolite) rather than naturally occurring Chabazite had a higher capacity for the adsorption of all three gases. Pure and binary gas isotherms of CH$\sb4$ and CO with molecular sieve 5A were also studied for the separation of these gases. These isotherms indicated that under the present conditions CO is preferentially adsorbed on the 5A zeolite and the adsorption capacity of the sieve increases with decreased temperature.
3645377.pdf
Creators: name: Choi, Youngwoon
name: Hosseini, Poorya
name: Kang, Jeon Woong
name: Kang, Sungsam
name: Yang, Taeseok
name: Hyeon, Min Gyu
name: Kim, Beop-Min
name: So, Peter
name: Yaqoob, Zahid
Publisher: name: Optica Publishing Group
Year: 2018
Subjects: Uncategorized

description: This document provides supplementary information to "Reflection phase microscopy using spatio-temporal coherence of light".
title: Reimagining inclusion in higher education
title: learning from the experiences of U.S. students with dis/abilities before and during the COVID-19 pandemic
titleType: Subtitle
Creators: name: Armour, Carly D.
Publisher: name: University of Iowa
Year: 2023
Subjects: covid
disabilities
graduate
undergraduate
universal design
public abstract
Higher Education

description: The COVID-19 global pandemic provided an opportunity to reassess pedagogies, practices, and policies in higher education. In this dissertation, I explored the experiences of undergraduate and graduate students with dis/abilities (SWDs) in higher education before and during the COVID-19 global pandemic. The first manuscript is a descriptive study that used the lens of the social model of disability to review and examine the responses of 218 U.S. SWDs who responded to a nationwide, online, self-administered survey regarding students’ adjustment experiences before and after the COVID-19 crisis began in Spring 2020. The second manuscript presents qualitative data from a single institution case study, which allowed me to compare pandemic-related experiences in Spring 2020 with experiences in the following academic year. Key findings revealed mixed reports of SWDs (a) being negatively or positively influenced by the shifts that occurred during the pandemic with issues that newly emerged or were exacerbated or alleviated; (b) having feelings of belonging or unbelonging as a multiply minoritized student; and (c) feeling unsafe to disclose their dis/ability or feeling that the accommodations process is complicated. Another key finding included the emerging barriers that graduate SWDs experienced during the pandemic. Together, these studies call for higher education administrators to deconstruct institutional gatekeeping and reimagine inclusion for SWDs through incorporating training for stakeholders, providing more funds for the student disability services office, and implementing universal design in all aspects of higher education.