cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Towards deterministic computation of internal stresses in additively manufactured materials under fatigue loading: part I
Creators: name: Awd, Mustafa
name: Labanie, Mhd Fateh
name: Möhring, Kerstin
name: Fatemi, Ali
name: Walther, Frank
Publisher: name: Technische Universität Dortmund
Year: 2020
Subjects: subject: Additive manufacturing
subject: Microcomputed tomography (µ-CT)
subject: Fatigue loading
subject: Cyclic plasticity
subject: Fatemi-Socie damage parameter
subject: 660
subject: Rapid Prototyping
subject: Mikrocomputertomographie
subject: Materialermüdung
subject: Deformationsverhalten

description: The ongoing studies of the influence of internal defects on fatigue strength of additively manufactured metals adopted an internal crack or notch-like model at which the threshold stress intensity factor is the driving mechanism of fatigue failure. The current article highlights a shortcoming of this approach and offers an alternative based on X-ray microcomputed tomography and cyclic plasticity with a hybrid formulation of Chaboche and Armstrong–Frederick material laws. The presented tessellation and geometrical transformation scheme enabled a significantly more realistic morphological representation of internal defects that yielded a cyclic strain within 2% of the experimental values. This means that cyclic plasticity models have an accurate prediction of mechanical properties without repeating a full set of experiments for additively manufactured arbitrary microstructures. The coupling with a material law that is oriented towards the treatment of cyclic hardening and softening enabled more accurate computation of internal stresses under cyclic loading than ever before owing to the maturity of tessellation and numerical tools since then. The resulting stress–strain distributions were used as input to the Fatemi–Socie damage model, based on which a successful calculation of fatigue lifetime became possible. Furthermore, acting stresses on the internal pores were shown to be more than 450% concerning the applied remote stress amplitude. The results are a pretext to a scale bridging numerical solution that accounts for the short crack formation stage based on microstructural damage.
description: Materials;13(10)
Tidal tails of open star clusters as probes to early gas expulsion II: Predictions for Gaia
Creators: name: Dinnbier, František
name: Kroupa, Pavel
Publisher: name: arXiv
Year: 2020
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We study the formation and evolution of the tidal tail released from a young Pleiades-like star cluster, due to expulsion of primordial gas in a realistic gravitational field of the Galaxy. The tidal tails (as well as clusters) are integrated from their embedded phase for 300 Myr. We vary star formation efficiencies (SFEs) from 33% to 100% and the timescales of gas expulsion as free parameters, and provide predictions for the morphology and kinematics of the evolved tail for each of the models. The resulting tail properties are intended for comparison with anticipated Gaia observations in order to constrain the poorly understood early conditions during the gas phase and gas expulsion. The simulations are performed with the code Nbody6 including a realistic external gravitational potential of the Galaxy, and an analytical approximation for the natal gaseous potential. Assuming that the Pleiades formed with rapid gas expulsion and an SFE of $\approx 30$%, the current Pleiades are surrounded by a rich tail extending from $\approx 150$ to $\approx 350$ pc from the cluster and containing 0.7 to 2.7 times the number of stars in the present-day cluster. If the Pleiades formed with an SFE close to 100%, then the tail is shorter ($\lesssim 90$ pc) and substantially poorer, containing only $\approx 2$% of the number of present-day cluster stars. If the Pleiades formed with an SFE of $\approx 30$%, but the gas expulsion was adiabatic, the tail signatures are indistinguishable from the case of the model with 100% SFE. The model takes into account the estimated contamination due to the field stars and the Hyades-Pleiades stream, which constitutes a more limiting factor than the accuracy of the Gaia measurements.
description: Accepted for publication in A&A, 27 pages, 15 figures, 4 tables
title: Προσδιοριστικοί παράγοντες διαρροής εγκεφάλων: μία έρευνα στις οικονομικές σχολές της Ελλάδος
title: Determining factors of brain drain: a research in the greek schools of economics
titleType: AlternativeTitle
Creators: name: Δημητροπούλου, Φλωρεντία
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2020
Subjects: subject: Μετανάστευση
subject: Κυκλοφορία επιστημονικού δυναμικού
subject: Υψηλή ειδίκευση
subject: Αίτια και αποτελέσματα
subject: Αγορά εργασίας

description: Η παρούσα διπλωματική εργασία με τίτλο «προσδιοριστικοί παράγοντες διαρροής εγκεφάλων: μια έρευνα στις οικονομικές σχολές της Ελλάδος» αποτελεί το αποτέλεσμα μιας ερευνητικής προσπάθειας η οποία πραγματοποιήθηκε στο Τμήμα Οικονομικής Επιστήμης του Πανεπιστημίου Πειραιώς στα πλαίσια του προγράμματος Μεταπτυχιακών σπουδών «Οικονομικά της Εκπαίδευσης». Η εργασία επιχειρεί να παρουσιάσει το φαινόμενο της διαρροής του ελληνικού επιστημονικού δυναμικού προς τις πιο ανεπτυγμένες χώρες σταχυολογώντας τα κύρια κριτήρια του μεταναστευτικού κινήματος τα τελευταία χρόνια. Αρχικά, έχοντας ως γνώμονα τις κατευθυντήριες γραμμές της υπάρχουσας βιβλιογραφίας ορίζεται ο όρος «Brain Drain», γίνεται μια σύντομη αναφορά στην ευρωπαϊκή πολιτική για το μεταναστευτικό, καθώς απαριθμούνται τα αίτια και οι επιπτώσεις του φαινομένου. Εν συνεχεία, μέσω της δειγματοληπτικής έρευνας εξετάζονται οι προθέσεις των σημερινών φοιτητών να μεταναστεύσουν στο εξωτερικό, καθώς και οι απόψεις τους σχετικά με την κατάσταση και τις προοπτικές που επικρατούν στην Ελλάδα. Τέλος, τα αποτελέσματα της έρευνας δείχνουν ότι το φαινόμενο της διαρροής επιστημονικού δυναμικού εκκολάπτεται με ταχείς ρυθμούς, με συνέπεια η χώρα να οδηγείται σε ένα φαύλο κύκλο περιορισμένης ανάπτυξης με υψηλά ποσοστά ανεργίας.
Reply to "Localized Behavior near the Zn Impurity in YBa2Cu4O8 as Measured By Nuclear Quadrupole Resonance"
Creators: name: Williams, G. V. M.
name: Kramer, S.
name: Tallon, J. L.
name: Dupree, R.
name: Loram, J. W.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Julien et al. have commented on two of our publications claiming that we have made erroneous interpretations of the nuclear magnetic resonance (NMR) and nuclear quadrupole resonance (NQR) data. Specifically, they believe that their model of an extended staggered moment about a Zn impurity is the only interpretation of the data [Julien et al., Phys. Rev Lett. 84, 3422 (2000)]. Not only does their claim ignore models presented by other authors, we show that the model of Julien et al. [Phys. Rev Lett. 84, 3422 (2000)] does not consistently reproduce all of the NMR data.
description: 16 pages in PDF format
Anti-inflammatory effect of supercritical extract and its constituents from Ishige okamurae
Creators: name: Ko, Eun-Yi
name: Yoon, Weon-Jong
name: Lee, Hae-Won
name: Heo, Soo-Jin
name: Ko, Young-Hwan
name: Fernando, I.P. Shanura
name: Cho, Kichul
name: Lee, Chi-Heon
name: Hur, Sung-Pyo
name: Cho, Su-Hyeon
name: Ahn, Ginnae
name: Kim, Daekyung
name: Kim, Kil-Nam
Publisher: name: Technische Universität Dortmund
Year: 2016
Subjects: subject: supercritical fluid extraction
subject: linoleic acid
subject: Ishige okamurae
subject: anti-inflammatory
subject: NF- κB
subject: 610

description: The anti-inflammatory properties of the supercritical fluid extract of Ishige okamurae (SFEIO) on lipopolysaccharide (LPS)-stimulated murine RAW 264.7 macrophages. The lipid profile of the SFEIO, reviled the presence of palmitic acid (220.2 mg/g), linoleic acid (168.0 mg/g), and oleic acid (123.0 mg/g). SFEIO was found to exert it’s anti-inflammatory effects through inhibiting nitric oxide (NO), prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 production in LPS-stimulated RAW 264.7 cells, without inducing cytotoxicity. SFEIO did not effect on the LPS-induced p38 kinase phosphorylation, whereas it attenuated the extracellular-related signaling kinase (ERK) and c-Jun N-terminal kinase (JNK) phosphorylation. Furthermore, SFEIO inhibited the LPS-induced IκB-α degradation and p50 NF-κB activation. These results suggest that SFEIO exerts its anti-inflammatory effects in LPS-activated RAW 264.7 cells by down-regulating the activation of ERK, JNK, and NF-κB.
description: EXCLI Journal;Vol. 15, 2016
Patent portfolio quality και μελλοντική απόδοση της εταιρίας
Creators: name: Ντάκας, Ιωάννης
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2021
Subjects: subject: Διπλώματα ευρεσιτεχνίας
subject: Πατέντες
subject: Αγοραία υπεραξία των επιχειρήσεων
subject: Λογαριθμική απόδοση του Tobin’s Q

description: Σκοπός της παρούσας έρευνας είναι να εξετάσει την ποιότητα των patent portfolio και πως επηρεάζει αλλά και πως επιδρά στο cross section των μετοχικών αποδόσεων και άλλων performance measures. Αντλήθηκαν στοιχεία για 2354 εταιρίες, οι οποίες είναι εισηγμένες στο Αμερικάνικο χρηματιστήριο, για τις περιόδους 2005-2019. Τα διπλώματα ευρεσιτεχνίας μπορούν να αυξήσουν την απόδοση των εταιριών και να είναι σημαντικά περιουσιακά στοιχεία για τις επιχειρήσεις που τα κατέχουν. Επίσης μεγάλο ενδιαφέρον παρουσιάζει η μελέτη που δείχνει την αύξηση της αγοραίας αξίας των εταιριών λόγω της ποιότητας των πατεντών(citations), δηλαδή η επίδραση που έχουν οι αναφορές που γίνονται στις πατέντες των εταιριών. Πρέπει να διευκρινιστεί ότι όσες περισσότερες αναφορές υπάρχουν για ένα δίπλωμα ευρεσιτεχνιών τόσο πιο πολύ αναφέρθηκε η εν λόγω πατέντα. Η υλοποίηση της έρευνας έγινε με την χρήση του στατιστικού προγράμματος stata με το οποίο δημιουργήθηκαν πίνακες συσχέτισης, πίνακας συνοπτικών στατιστικών στοιχείων καθώς και πίνακας αποτελεσμάτων. Από αυτούς τους πίνακες αντλήθηκε ότι υπάρχουν στατιστικά σημαντικές αποδόσεις σχετικά με την χρήση των διπλωμάτων ευρεσιτεχνίας και την απόδοση των επιχειρήσεων. Επιπροσθέτως παρατηρήθηκε θετική συσχέτιση των διπλωμάτων ευρεσιτεχνίας προς το σύνολο του ενεργητικού με την λογαριθμική απόδοση του Tobin’s Q.
On the Hamiltonian reduction of geodesic motion on SU(3) to SU(3)/SU(2)
Creators: name: Gerdt, V.
name: Horan, R.
name: Khvedelidze, A.
name: Lavelle, M.
name: McMullan, D.
name: Palii, Yu.
Publisher: name: arXiv
Year: 2005
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: The reduced Hamiltonian system on T*SU(3)/SU(2)) is derived from a Riemannian geodesic motion on the SU(3) group manifold parameterised by the generalised Euler angles and endowed with a bi-invariant metric. Our calculations show that the metric defined by the derived reduced Hamiltonian flow on the orbit space SU(3)/SU(2)=S^5 is not isometric or even geodesically equivalent to the standard Riemannian metric on the five-sphere S^5 embedded into R^6.
description: 36 pages
Prebiotic Homochirality as a Critical Phenomenon
Creators: name: Gleiser, Marcelo
name: Thorarinson, Joel
Publisher: name: arXiv
Year: 2006
Subjects: subject: Astrophysics (astro-ph)
subject: Biomolecules (q-bio.BM)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: The development of prebiotic homochirality on early-Earth or another planetary platform may be viewed as a critical phenomenon. It is shown, in the context of spatio-temporal polymerization reaction networks, that environmental effects -- be them temperature surges or other external disruptions -- may destroy any net chirality previously produced. In order to understand the emergence of prebiotic homochirality it is important to model the coupling of polymerization reaction networks to different planetary environments.
description: 6 Pages, 1 Figure, In Press: Origins of Life and Evolution of Biospheres
Η πολιτική υπαγωγή στην κρατική και δημοτική διοίκηση και το νομοθετικό σώμα και η επίδραση της στην ανισότητα βιωσιμότητας και καινοτομίας
Creators: name: Σέγκου, Πολυξένη
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2021
Subjects: subject: Πολιτική
subject: Δήμαρχοι
subject: Γερουσία
subject: ΗΠΑ
subject: Βιωσιμότητα
subject: Καινοτομία
subject: Ανισότητα
subject: MSA
subject: Δημοκρατικό κόμμα
subject: Ρεπουμπλικανικό κόμμα

description: Η πολιτική αναμένεται να επηρεάζει έντονα την εξέλιξη των πραγμάτων και συγκεκριμένα τη βιωσιμότητα του πλανήτη, την ανισότητα και την καινοτομία. Η κάθε πολιτική είναι ξεχωριστή για αυτό ασχολούμαστε με τις ΗΠΑ και τα δύο κόμματά τους, το δημοκρατικό και το ρεπουμπλικανικό κόμμα. Κάθε κόμμα αντιδράει ξεχωριστά κι αυτό θέλουμε να δούμε πώς εφαρμόζεται.
Nonlocal Effective Gravitational Field Equations and the Running of Newton's G
Creators: name: Hamber, Herbert W.
name: Williams, Ruth M.
Publisher: name: arXiv
Year: 2005
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Astrophysics (astro-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Non-perturbative studies of quantum gravity have recently suggested the possibility that the strength of gravitational interactions might slowly increase with distance. Here a set of generally covariant effective field equations are proposed, which are intended to incorporate the gravitational, vacuum-polarization induced, running of Newton's constant $G$. One attractive feature of this approach is that, from an underlying quantum gravity perspective, the resulting long distance (or large time) effective gravitational action inherits only one adjustable parameter $ξ$, having the units of a length, arising from dimensional transmutation in the gravitational sector. Assuming the above scenario to be correct, some simple predictions for the long distance corrections to the classical standard model Robertson-Walker metric are worked out in detail, with the results formulated as much as possible in a model-independent framework. It is found that the theory, even in the limit of vanishing renormalized cosmological constant, generally predicts an accelerated power-law expansion at later times $t \sim ξ\sim 1/H$.
description: 33 pages
Physical Implementability of Linear Maps and Its Application in Error Mitigation
Creators: name: Jiang, Jiaqing
name: Wang, Kun
name: Wang, Xin
Publisher: name: arXiv
Year: 2020
Subjects: subject: Quantum Physics (quant-ph)
subject: Information Theory (cs.IT)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Completely positive and trace-preserving maps characterize physically implementable quantum operations. On the other hand, general linear maps, such as positive but not completely positive maps, which can not be physically implemented, are fundamental ingredients in quantum information, both in theoretical and practical perspectives. This raises the question of how well one can simulate or approximate the action of a general linear map by physically implementable operations. In this work, we introduce a systematic framework to resolve this task using the quasiprobability decomposition technique. We decompose a target linear map into a linear combination of physically implementable operations and introduce the physical implementability measure as the least amount of negative portion that the quasiprobability must pertain, which directly quantifies the cost of simulating a given map using physically implementable quantum operations. We show this measure is efficiently computable by semidefinite programs and prove several properties of this measure, such as faithfulness, additivity, and unitary invariance. We derive lower and upper bounds in terms of the Choi operator's trace norm and obtain analytic expressions for several linear maps of practical interests. Furthermore, we endow this measure with an operational meaning within the quantum error mitigation scenario: it establishes the lower bound of the sampling cost achievable via the quasiprobability decomposition technique. In particular, for parallel quantum noises, we show that global error mitigation has no advantage over local error mitigation.
description: 25 pages, v2 accepted by Quantum
Preclinical safety evaluation of low molecular weight galactomannans based standardized fenugreek seeds extract
Creators: name: Deshpande, Pallavi
name: Mohan, Vishwaraman
name: Thakurdesai, Prasad
Publisher: name: Technische Universität Dortmund
Year: 2016
Subjects: subject: low molecular weight galactomannans
subject: fenugreek seed extract
subject: acute oral toxicity
subject: subchronic toxicity
subject: mutagenicity
subject: OECD guidelines
subject: 610

description: The objective of the present study was to evaluate acute oral toxicity, subchronic toxicity, and mutagenic potential of low molecular weight galactomannans based standardized fenugreek seeds extract (LMWGAL-TF) in laboratory animals rats as per Organization for Economic Co-operation and Development (OECD) guidelines. For the acute toxicity (AOT) study, LMWGAL-TF was orally administered to Sprague-Dawley (SD) rats at a dose of 2000 mg/kg with vehicle control (VC) group (n = 5 per sex per group) as per OECD guideline no. 423. For the repeated dose toxicity study, the SD rats were orally administered with a daily oral dose of LMWGAL-TF 250, 500 and 1000 mg/kg/day with VC group (n = 15 per sex) for a period of 90 days followed by a recovery period of 28 days as per OECD guideline no. 408. The effects on body weight, food and water consumption, organ weights with hematology, clinical biochemistry, and histology were studied. The mutagenic potential of LMWGAL-TF was tested using reverse mutation assay (AMES test, OECD guideline No. 471). The LMWGAL-TF did not show mortality or treatment-related adverse signs during acute (dose 2000 mg/kg) and subchronic (90-days repeated dose 250, 500 and 1000 mg/kg) administration. The LMWGAL-TF showed oral lethal dose (LD50) more than 2000 mg/kg during AOT study. The dose of 1000 mg/kg was found as no observed adverse effect level (NOAEL) in rats during subchronic toxicity study. Furthermore, LMWGAL-TF did not show mutagenic potential in vitro. In conclusion, LMWGAL-TF was found safe during acute and subchronic (90 days repeated dose) toxicity studies in rats with no mutagenicity.
description: EXCLI Journal;Vol. 15, 2016
Raman solitons in waveguides with simultaneous quadratic and Kerr nonlinearities
Creators: name: Rowe, William R.
name: Skryabin, Dmitry V.
name: Gorbach, Andrey V.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Optics (physics.optics)
subject: Pattern Formation and Solitons (nlin.PS)
subject: FOS: Physical sciences

description: We analyse Raman-induced self-frequency shift in two-component solitons supported by both quadratic and cubic nonlinearities. Treating Raman terms as a perturbation, we derive expressions for soliton velocity and frequency shifts of the fundamental frequency and second harmonic soliton components. We find these predictions compare well with simulations of soliton propagation. We also show that Raman shift can cause two-component solitons to approach the boundary of their own existence and subsequently trigger soliton instabilities. In some cases these instabilities are accompanied by an almost complete transfer of power to the second harmonic, and emergence of a single-component Kerr solitonic pulse.
description: 10 pages, 5 figures
Combining weak and strong lensing in cluster potential reconstruction
Creators: name: Cacciato, M.
name: Bartelmann, M.
name: Meneghetti, M.
name: Moscardini, L.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We propose a method for recovering the two-dimensional gravitational potential of galaxy clusters which combines data from weak and strong gravitational lensing. A first estimate of the potential from weak lensing is improved at the approximate locations of critical curves. The method can be fully linearised and does not rely on the existence and identification of multiple images. We use simulations to show that it recovers the surface-mass density profiles and distributions very accurately, even if critical curves are only partially known and if their location is realistically uncertain. We further describe how arcs at different redshifts can be combined, and how deviations from weak lensing can be included.
description: 9 pages, 5 figures, A&A in press, changes to match the accepted version
Cancer microarray data feature selection using Multi-Objective Binary Particle Swarm Optimization algorithm
Creators: name: Annavarapu, Chandra Sekhara Rao
name: Dara, Suresh
name: Banka, Haider
Publisher: name: Technische Universität Dortmund
Year: 2016
Subjects: subject: cancer micro array
subject: gene expressions
subject: feature selection
subject: binary PSO
subject: classification
subject: 610

description: Cancer investigations in microarray data play a major role in cancer analysis and the treatment. Cancer microarray data consists of complex gene expressed patterns of cancer. In this article, a Multi-Objective Binary Particle Swarm Optimization (MOBPSO) algorithm is proposed for analyzing cancer gene expression data. Due to its high dimensionality, a fast heuristic based pre-processing technique is employed to reduce some of the crude domain features from the initial feature set. Since these pre-processed and reduced features are still high dimensional, the proposed MOBPSO algorithm is used for finding further feature subsets. The objective functions are suitably modeled by optimizing two conflicting objectives i.e., cardinality of feature subsets and distinctive capability of those selected subsets. As these two objective functions are conflicting in nature, they are more suitable for multi-objective modeling. The experiments are carried out on benchmark gene expression datasets, i.e., Colon, Lymphoma and Leukaemia available in literature. The performance of the selected feature subsets with their classification accuracy and validated using 10 fold cross validation techniques. A detailed comparative study is also made to show the betterment or competitiveness of the proposed algorithm.
description: EXCLI Journal;Vol. 15, 2016
Keyhole limpet hemocyanin induces innate immunity via Syk and Erk phosphorylation
Creators: name: Yasuda, Kyoko
name: Ushio, Hideki
Publisher: name: Technische Universität Dortmund
Year: 2016
Subjects: subject: keyhole limpet hemocyanin
subject: innate immunity
subject: NF-kB
subject: Syk
subject: Erk
subject: 610

description: Hemocyanin is an extracellular respiratory protein containing copper in hemolymph of invertebrates, such as Mollusk and Arthropod. Keyhole limpet hemocyanin (KLH) is one of hemocyanins and has many years of experience for vaccine developments and immunological studies in mammals including human. However, the association between KLH and the immune systems, especially the innate immune systems, remains poorly understood. The aim of this study is to clarify the direct effects of KLH on the innate immune systems. KLH activated an inflammation-related transcription factor NF-kB as much as lipopolysaccharide (LPS) in a human monocytic leukemia THP-1 reporter cell line. We have found that the KLH-induced NF-kB activation is partially involved in a spleen tyrosine kinase (Syk) pathway. We have also successfully revealed that an extracellular signal-regulated kinase (Erk), a member of mitogen-activated protein kinases, is located in an upstream of NF-kB activation induced by KLH. Furthermore, a Syk phosphorylation inhibitor partially suppressed the Erk activation in KLH-stimulated THP-1. These results suggest that both Syk and Erk associate with the KLH-induced NF-kB activation in the human monocyte.
description: EXCLI Journal;Vol. 15, 2016
Unlocking Microdroplet Curious Chemistry through Single Entity Electrochemistry
Creators: name: Krushinski, Lynn Elizabeth
Publisher: name: Purdue University Graduate School
Year: 2024
Subjects: classificationCode: 340103
subject: Electroanalytical chemistry

description: Microdroplets (typically less than 10 μm in radius) have proven to be unique reaction vessels capable of doing the seemingly impossible: drive the chemistry that could have made life possible. While I am not a biochemist here to explain the intricacies of such a claim, I am a measurement scientist who has worked for the past three and half years to develop new methods which can be used to unveil new chemistries in these droplets. Before electrochemists like me entered the microdroplet realm, mass spectrometrists spent years studying droplets at this scale (typically generated with electrospray methods) and have been able to show that these droplets can promote reaction acceleration by several orders of magnitude, spontaneous generation of reactive species such as water and hydroxide radicals as well as hydrogen peroxide, and other curious chemistries. While these studies have changed the way that scientists view microdroplets, they all require the analysis of thousands of droplets in tandem where values are extrapolated back to the average droplet. The robust correlation of chemistry in an individual droplet of a specific size requires the development of new measurement tools capable of accessing single sub-femtoliter droplets, one at a time. Here, I describe the development of new electrochemical measurement tools which have been used to access this curious chemistry at the single droplet level as well as the implications of the findings from the implementation of these tools. First, stochastic electrochemistry, a method where an electrode effectively “fishes” for droplets suspended in an oil phase, will be outlined and it’s use to probe the spontaneous generation of hydrogen peroxide in such droplets will be presented. Afterwards, a method used for the electroanalysis of droplets in air, or aerosols, where an ionic liquid bubble (suspended by a platinum bubble wand) captures droplets to be analyzed at a carbon fiber wire thread through the middle, will be outlined. The use of these two techniques to correlate enzymatic activity in both droplet types, droplets in oil and aerosols, will then reveal that the gas|liquid interface promotes higher turnover rate acceleration for glucose oxidase. Finally, the fabrication and use of a dual-barrel electrode for the analysis of an acoustically levitated droplet will be presented. These three techniques stand to make electrochemistry a pivotal technique for the analysis of the curious chemistry housed within individual microdroplets. In addition to these methods, methods for extending electrochemistry to the next generation of scientists are presented.
Clustering algorithm selection by meta-learning
Creators: name: Παναγιωτόπουλος, Γεώργιος
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2020
Subjects: subject: Clustering
subject: Data characterization
subject: Meta-learning
subject: Algorithm ranking
subject: Algorithm selection
subject: Meta-knowledge

description: Η συσταδοποίηση δεδομένων είναι μια προσπάθεια ομαδοποίησης μιας βάσης δεδομένων σε ομάδες αντικειμένων βασισμένες στις ομοιότητες των εν λόγω αντικειμένων. Η αναζήτηση μιας ποιοτικής λύσης μπορεί να γίνει μια περίπλοκη διαδικασία λόγω απουσίας της επιτήρησης. Αυτή τη στιγμή υπάρχει ένα ευρύ φάσμα αλγορίθμων ομαδοποίησης και μπορεί να είναι μια αργή και δαπανηρή διαδικασία για την επιλογή του καλύτερου για ένα δεδομένο πρόβλημα. Για κάθε σύνολο δεδομένων που σχετίζεται με προβλήματα ομαδοποίησης, υπάρχει μια εξαντλητική διαδικασία που ζητά από έναν Data Scientist πρώτα να ελέγξει κάθε αλγόριθμο ομαδοποίησης για να βρει το πιο κατάλληλο. Ένα σύστημα που συνιστά τον αλγόριθμο ομαδοποίησης και καθοδηγεί τον χρήστη για την επιλογή του σωστού θα ήταν ένα εξαιρετικό εργαλείο που θα προσέφερε σημαντικά οφέλη στην επιστημονική κοινότητα. Ο Ράις διατύπωσε το πρόβλημα επιλογής αλγορίθμου (ASP) το 1976, το οποίο υποθέτει ότι η παραγωγή του αλγορίθμου μπορεί να προβλεφθεί με βάση τα δομικά χαρακτηριστικά του προβλήματος. Η μετα-μάθηση έχει χρησιμοποιηθεί με επιτυχία για εργασίες συστάσεων με αλγόριθμους. Χρησιμοποιεί την εκμάθηση μηχανών για να προκαλέσει μετα-μοντέλα ικανά να προβλέψουν τον καλύτερο αλγόριθμο ενός νέου συνόλου δεδομένων. Τα πειραματικά αποτελέσματα δείχνουν ότι η σύσταση βελτιώνεται με αυτά τα μετα-χαρακτηριστικά. Με σημαντική ακρίβεια, παρουσιάζεται ότι ένα σύστημα θα μπορούσε πράγματι να συστήσει έναν αλγόριθμο ομαδοποίησης για ένα "άγνωστο" σύνολο δεδομένων μόνο εξετάζοντας πρώτα τα μετα-χαρακτηριστικά του. Τέλος, αυτή η Διπλωματική εξετάζει τη συνάφεια με τη σύσταση κάθε μετα-χαρακτηριστικού.
Ferulic acid ameliorates TNBS-induced ulcerative colitis through modulation of cytokines, oxidative stress, iNOs, COX-2, and apoptosis in laboratory rats
Creators: name: Sadar, Smeeta S.
name: Vyawahare, Niraj S.
name: Bodhankar, Subhash L.
Publisher: name: Technische Universität Dortmund
Year: 2016
Subjects: subject: Ferulic acid
subject: TNBS-induced colitis
subject: apoptosis
subject: TNF- α
subject: IL-1 β
subject: IL-6
subject: COX-2
subject: iNOs
subject: 610

description: Ulcerative colitis (UC) is a chronic immune-inflammatory disorder characterized by oxido-nitrosative stress, the release of pro-inflammatory cytokines and apoptosis. Ferulic acid (FA), a phenolic compound is considered to possess potent antioxidant, anti-apoptotic and anti-inflammatory activities. The aim is to evaluate possible mechanism of action of FA against trinitrobenzensulfonic acid (TNBS) induced ulcerative colitis (UC) in rats. UC was induced in Sprague-Dawley rats (150-200 g) by intrarectal administration of TNBS (100 mg/kg). FA was administered (10, 20 and 40 mg/kg, p.o.) for 14 days after colitis was induced. Various biochemical, molecular and histological changes were assessed in the colon. Intrarectal administration of TNBS caused significant induction of ulcer in the colon with an elevation of oxido-nitrosative stress, myeloperoxidase and hydroxyproline activity in the colon. Administration of FA (20 and 40 mg/kg) significantly decrease oxido-nitrosative stress, myelope¬roxidase, and hydroxyproline activities. Up-regulated mRNA expression of TNF-α, IL-1β, IL-6, COX-2, and iNOs, as well as down-regulated IL-10 mRNA expressions after TNBS administration, were significantly inhibited by FA (20 and 40 mg/kg) treatment. Flow cytometric analysis revealed that intrarectal administration of TNBS-induced significantly enhanced the colonic apoptosis whereas administration of FA (20 and 40 mg/kg) significantly restored the elevated apoptosis. FA administration also significantly restored the histopathological aberration induced by TNBS. The findings of the present study demonstrated that FA ameliorates TNBS-induced colitis via inhibition of oxido-nitrosative stress, apoptosis, proinflammatory cytokines production, and down- regulation of COX-2 synthesis.
description: EXCLI Journal;Vol. 15, 2016
Οικονομοτεχνική ανάλυση και αξιολόγηση νέας ξενοδοχειακής μονάδας για καταδυτικό τουρισμό στην Κύμη Ευβοίας
Creators: name: Μαρμαρά, Αναστασία
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2020
Subjects: subject: Οικονομοτεχνική ανάλυση
subject: Ανάλυση αγοράς
subject: Καταδυτικός τουρισμός
subject: Ελλάδα
subject: Κύμη Ευβοίας
subject: Επενδυτικό σχέδιο
subject: Μάρκετινγκ
subject: Ανθρώπινοι πόροι

description: Το συγκεκριμένο επενδυτικό σχέδιο αναφέρεται στη δημιουργία μιας ξενοδοχειακής μονάδας εναλλακτικού τουρισμού, πιο συγκεκριμένα καταδυτικού τουρισμού στην Κύμη Ευβοίας. Στο 1ο κεφάλαιο παρουσιάζεται η σύνοψη της μελέτης σκοπιμότητας, στο 2ο κεφάλαιο η βασική ιδέα και το ιστορικό του προγράμματος, στο 3ο κεφάλαιο η ανάλυση αγοράς και του μάρκετινγκ, στο 4ο κεφάλαιο οι πρώτες ύλες και τα άλλα εφόδια, στο 5ο κεφάλαιο η μηχανολογία και η τεχνολογία του ξενοδοχείου, στο 6ο κεφάλαιο η οργάνωση της μονάδας και τα γενικά έξοδα, στο 7ο κεφάλαιο οι ανθρώπινοι πόροι, στο 8ο κεφάλαιο η τοποθεσία και το περιβάλλον, στο 9ο κεφάλαιο ο προγραμματισμός και ο προϋπολογισμός του έργου και τέλος στο 10ο κεφάλαιο παρουσιάζεται η χρηματοοικονομική ανάλυσή του.
Multi-modal Transfer Learning for Grasping Transparent and Specular Objects
Creators: name: Weng, Thomas
name: Pallankize, Amith
name: Tang, Yimin
name: Kroemer, Oliver
name: Held, David
Publisher: name: arXiv
Year: 2020
Subjects: subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: State-of-the-art object grasping methods rely on depth sensing to plan robust grasps, but commercially available depth sensors fail to detect transparent and specular objects. To improve grasping performance on such objects, we introduce a method for learning a multi-modal perception model by bootstrapping from an existing uni-modal model. This transfer learning approach requires only a pre-existing uni-modal grasping model and paired multi-modal image data for training, foregoing the need for ground-truth grasp success labels nor real grasp attempts. Our experiments demonstrate that our approach is able to reliably grasp transparent and reflective objects. Video and supplementary material are available at https://sites.google.com/view/transparent-specular-grasping.
description: RA-L with presentation at ICRA 2020
Automatic liver segmentation on computed tomography using random walkers for treatment planning
Creators: name: Moghbel, Mehrdad
name: Mashohor, Syamsiah
name: Mahmud, Rozi
name: Saripana, M. Iqbal Bin
Publisher: name: Technische Universität Dortmund
Year: 2016
Subjects: subject: image segmentation
subject: random walker
subject: CT imaging
subject: liver segmentation
subject: 610

description: Segmentation of the liver from Computed Tomography (CT) volumes plays an important role during the choice of treatment strategies for liver diseases. Despite lots of attention, liver segmentation remains a challenging task due to the lack of visible edges on most boundaries of the liver coupled with high variability of both intensity patterns and anatomical appearances with all these difficulties becoming more prominent in pathological livers. To achieve a more accurate segmentation, a random walker based framework is proposed that can segment contrast-enhanced livers CT images with great accuracy and speed. Based on the location of the right lung lobe, the liver dome is automatically detected thus eliminating the need for manual initialization. The computational requirements are further minimized utilizing rib-caged area segmentation, the liver is then extracted by utilizing random walker method. The proposed method was able to achieve one of the highest accuracies reported in the literature against a mixed healthy and pathological liver dataset compared to other segmentation methods with an overlap error of 4.47 % and dice similarity coefficient of 0.94 while it showed exceptional accuracy on segmenting the pathological livers with an overlap error of 5.95 % and dice similarity coefficient of 0.91.
description: EXCLI Journal;Vol. 15, 2016
Erfahrungen mit einer Polypolversion des Pachtmarktspiels "Wachsen oder Weichen"
Creators: name: Witzke, Heinz Peter
name: Witzke, Heinz Peter
Publisher: name: Unknown
Year: 1998
Subjects: Land Economics/Use

description: This paper summarises results from the well known game "Wachsen oder Weichen" which mimics characteristics of a land rental market. The original version of the game from Gottingen University has been greatly simplified to investigate the influence of planning errors on outcomes in a game played among agricultural economists at Bonn University. It turned out that players' errors continued to bias the results against the tenants even in the simplified version of the game. Other sources of bias are also discussed in the paper which concludes with suggestions for improvements. Dieses Diskussionspapier faßt Ergebnisse einer Spielrunde mit dem bekannten Pachtmarktspiel "Wachsen oder Weichen" zusammen. Die ursprungliche Version des Spiels aus Gottingen wurde stark vereinfacht, um den Einfluss von Planungsfehlern auf die Ergebnisse zu untersuchen. Planungsfehler verursachten weiterhin eine gewisse Verzerrung des Spielverlaufs zuungunsten der pachtenden Spieler. Weitere Ursachen fur derartige Verzerrungen werden zusammen mit Verbesserungsvorschlagen diskutiert.
The Chandra High Energy Transmission Grating: Design, Fabrication, Ground Calibration and Five Years in Flight
Creators: name: Canizares, Claude R.
name: Davis, John E.
name: Dewey, Daniel
name: Flanagan, Kathryn A.
name: Galton, Eugene B.
name: Huenemoerder, David P.
name: Ishibashi, Kazunori
name: Markert, Thomas H.
name: Marshall, Herman L.
name: McGuirk, Michael
name: Schattenburg, Mark L.
name: Schulz, Norbert S.
name: Smith, Henry I.
name: Wise, Michael
Publisher: name: arXiv
Year: 2005
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Details of the design, fabrication, ground and flight calibration of the High Energy Transmission Grating, HETG, on the Chandra X-ray Observatory are presented after five years of flight experience. Specifics include the theory of phased transmission gratings as applied to the HETG, the Rowland design of the spectrometer, details of the grating fabrication techniques, and the results of ground testing and calibration of the HETG. For nearly six years the HETG has operated essentially as designed, although it has presented some subtle flight calibration effects.
description: 34 pages (including 30 figures), accepted for publication in PASP
Comparative Analysis of World Market Projections with Special Regard to Wheat Prices
Creators: name: Heckelei, Thomas
name: Krebs, Elvira
name: Mollmann, Claus
name: Von Lampe, Martin
name: Heckelei, Thomas
name: Krebs, Elvira
name: Mollmann, Claus
name: Von Lampe, Martin
Publisher: name: Unknown
Year: 1998
Subjects: Demand and Price Analysis

description: This paper presents a short comparative analysis of USDA and FAPRI projections for world wheat market prices until 2005. The relevance of different model assumptions regarding assumed inflation, exchange rates, policy parameters as well as shifts in demand and production development are discussed. A subsequent section focuses on the problem of a "world market price concept" for evaluating the potential of unsubsidized EU cereal exports. The Annex provides more detailed information on model assumptions and a comparison of other projected values, also including agricultural products other than wheat. Dieses Diskussionspapier stellt eine kurze vergleichende Analyse aktueller USDA- und FAPRI- Projektionen von Weltmarktpreisen fur Weizen bis 2005 vor. Die Relevanz verschiedener Modellannahmen hinsichtlich Inflation, Wechselkurs, Politikparameter und Bestimmungsgrossen von Angebot und Nachfrage werden diskutiert. Einige Uberlegungen zur Problematik eines "Weltmarktpreiskonzeptes" bei der Abschatzung des Potentials unsubventionierter EU Getreideexporte schliessen sich an. Der Anhang stellt detailliertere Informationen zu Modellannahmen sowie den Vergleich weiterer projezierter Kennzahlen bereit, die auch andere Agrarprodukte einschliessen.
Η οικονομία του ηλεκτρονικού νομίσματος
Creators: name: Μπρούμας, Θεόδωρος
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2020
Subjects: subject: Κρυπτονομίσματα
subject: Ηλεκτρονικό νόμισμα
subject: Οικονομία
subject: Θεσμικό πλαίσιο
subject: Blockchain

description: Τα κρυπτονομίσματα είναι ένα κρυπτογραφημένο δίκτυο peer-to-peer για τη διευκόλυνση της ψηφιακής ανταλλαγής.Είναι μια τεχνολογία που αναπτύχθηκε πριν από οκτώ χρόνια. Ενώ τα κρυπτονομίσματα δεν είναι πιθανό να αντικαταστήσουν το παραδοσιακό νόμισμα, θα μπορούσαν να αλλάξουν τον τρόπο αλληλεπίδρασης των παγκόσμιων αγορών συνδεδεμένων με το Διαδίκτυο, απομακρύνοντας τα εμπόδια γύρω από τα εθνικά νομίσματα και τις συναλλαγματικές ισοτιμίες. Η τεχνολογία προχωρεί με ταχύ ρυθμό και η επιτυχία μιας δεδομένης τεχνολογίας υπαγορεύεται σχεδόν αποκλειστικά από την αγορά στην οποία επιδιώκει να βελτιωθεί. Τα κρυπτονομίσματα μπορούν να φέρουν την επανάσταση στις αγορές ψηφιακού εμπορίου δημιουργώντας ένα ελεύθερο εμπορικό σύστημα χωρίς χρεώσεις/φόρους. Η παρούσα εργασία με τίτλο «Η οικονομία του ηλεκτρονικού νομίσματος» εξηγεί και αναλύει όλο το φάσμα των ενεργειών για την δημιουργία ,την αγορά και την πώληση των κρυπτονομισμάτων. Επίσης αναλύεται η τεχνολογία πάνω στην οποία βασίζονται τα κρυπτονομίσματα, δηλαδή της αλυσίδας Blockchain. Η κατανόηση της ικανότητας των κρυπτονομισμάτων να αντικαταστήσουν τα τρέχοντα νομίσματα απαιτεί μια εξέταση του βαθμού στον οποίο τα κρυπτονομίσματα πληρούν τα κύρια χαρακτηριστικά του χρήματος, δηλαδή ένα μέτρο αξίας, μια αποθήκη αξίας και ένα μέσο ανταλλαγής.Το δεύτερο θέμα είναι το πώς τα κρυπτονομίσματα ενδέχεται να αλλάξουν τη φύση της νομισματικής πολιτικής και την εφαρμογή της. Η διαχείριση του παραδοσιακού χρήματος από τις αρχές νομισματικής πολιτικής είναι εν μέρει αυτόματη και εν μέρει διακριτική. Το πρωτόκολλο κρυπτογράφησης λειτουργεί με έναν προκαθορισμένο αλγόριθμο, καθιστώντας τη διαχείρισή του πλήρως αυτόματη. Είναι δύσκολο σήμερα να φανταστούμε πώς οι αλγόριθμοι θα μπορούσαν να είναι πλήρως αποτελεσματικοί στην αντιμετώπιση πολύπλοκων αποφάσεων σε έναν αβέβαιο κόσμο. Το πιο σημαντικό όμως είναι ότι η έλλειψη πραγματικού προσώπου πίσω από την αυτόματη λήψη αποφάσεων συνεπάγεται ότι τέτοιοι αλγόριθμοι δεν θα μπορούσαν να ληφθούν υπόψη. Αυτό αποτελεί σημαντικό κενό επειδή η αξία ενός νομίσματος αποτελεί βασικό στοιχείο της ικανότητας της κοινωνίας να ευημερεί και ως εκ τούτου η λήψη αποφάσεων σε σχέση με αυτό το νόμισμα είναι μια δύναμη που πρέπει να παρακολουθείται προσεκτικά. Οι υπεύθυνοι για τη νομισματική πολιτική στους οποίους χορηγείται αυτή η εξουσία αποτελούν μέρος της δέσμης εθνικών πολιτικών που υπόκεινται σε παρακολούθηση και αναθεώρηση.
Nonabelian Strings and Axion
Creators: name: Gorsky, A.
name: Shifman, M.
name: Yung, A.
Publisher: name: arXiv
Year: 2006
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We address two distinct but related issues: (i) the impact of (two-dimensional) axions in a two-dimensional theory known to model confinement, the CP(N-1) model; (ii) bulk axions in four-dimensional Yang-Mills theory supporting non-Abelian strings. In the first case n, \bar n kinks play the role of "quarks." They are known to be confined. We show that introduction of axions leads to deconfinement (at very large distances). This is akin to the phenomenon of wall liberation in four-dimensional Yang-Mills theory. In the second case we demonstrate that the bulk axion does not liberate confined (anti)monopoles, in contradistinction with the two-dimensional model. A novel physical effect which we observe is the axion radiation caused by monopole-antimonopole pairs attached to the non-Abelian strings.
description: 16 pp, 4 figures
Σύγχρονες τάσεις στη λήψη επενδυτικών αποφάσεων και χρηματοδότησης στη ναυτιλία
Creators: name: Μπίλος, Κωνσταντίνος
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2020
Subjects: subject: Επενδυτικές αποφάσεις
subject: Χρηματοδότηση

description: Ο ναυτιλιακός κλάδος αποτελεί ένα από τα σημαντικότερα κομμάτια της παγκόσμιας οικονομίας, ενώ η πολυπλοκότητα που τον διακρίνει αλλά και οι απρόβλεπτες συνθήκες που επικρατούν καθιστούν απαραίτητη τη χρήση μεθόδων αξιολόγησης επενδύσεων που βοηθούν στη λήψη επενδυτικών αποφάσεων. Ακόμη, η ανάγκη για άντληση μεγάλων ποσών κεφαλαίου με διάφορους τρόπους χρηματοδότησης δημιουργεί ένα περιβάλλον ανταγωνισμού γύρω από τη ναυτιλιακή χρηματοδότηση, όπου ο καλύτερος παίκτης είναι εκείνος που κλείνει και τις καλύτερες συμφωνίες. Η παρούσα εργασία σκοπό έχει να μελετήσει και να αναδείξει όλες τις μεθόδους που χρησιμοποιούνται για την αξιολόγηση και τη λήψη επενδυτικών αποφάσεων, με έμφαση σε εκείνες που είτε δεν υπήρχαν στο παρελθόν, είτε υπήρχαν αλλά η χρήση τους έγινε εντονότερη τα τελευταία χρόνια. Για την ακρίβεια θα αναφέρουμε και θα αναλύσουμε τις τεχνικές που χρησιμοποιούν οι εταιρίες για έγκριση ή απόρριψη ενός επενδυτικού σχεδίου, ενώ θα ακολουθήσει και σύγκριση μεταξύ τους. Ακόμη, θα μελετήσουμε τους σημαντικότερους τρόπους αντιστάθμισης κινδύνων, τους οποίους αντιμετωπίζει καθημερινά μια ναυτιλιακή επιχείρηση χρησιμοποιώντας κυρίως παράγωγα προϊόντα και πως αυτό μπορεί επηρεάσει τις οικονομικές και ναυτιλιακές της επιδόσεις. Τέλος, θα αναλύσουμε όλους τους τρόπους χρηματοδότησης για μια ναυτιλιακή εταιρία καθώς και το ποιοι από αυτούς χρησιμοποιούνται περισσότερο τα τελευταία χρόνια και για ποιον λόγο, ενώ θα γίνει μια σύγκριση σε σχέση με το πως λειτουργούσε το χρηματοπιστωτικό σύστημα πριν την κρίση του 2008, και πως επηρέασε αυτή η αναταραχή τις αποφάσεις των πλοιοκτητών για τον τρόπο άντλησης κεφαλαίων. Πιο συγκεκριμένα, θα αναφερθούμε στις καινούριες κατευθυντήριες γραμμές που αφορούν κυρίως την τραπεζική χρηματοδότηση, και πως αυτές έχουν επηρεάσει τις σχέσεις των εταιριών με την επί χρόνια βασικότερη πηγή χρηματοδότησής τους που είναι οι τράπεζες.
Quantification of rutin in rats brain by UHPLC/ESI-Q-TOF-MS/MS after intranasal administration of rutin loaded chitosan nanoparticles
Creators: name: Ahmad, Niyaz
name: Ahmad, Rizwan
name: Naqvi, Atta Abbas
name: Alam, Md Aftab
name: Samim, Mohd
name: Iqbal, Zeenat
name: Ahmad, Farhan Jalees
Publisher: name: Technische Universität Dortmund
Year: 2016
Subjects: subject: Rutin
subject: UHPLC-MS/MS-ESI-Q-TOF
subject: method development and validation
subject: chitosan nanoparticles
subject: brain pharmacokinetic
subject: 610

description: Rutin (RT), an antioxidant drug, has been utilized to treat cerebral ischemia hence a sensitive quantification method for estimation of RT in brain homogenate is necessary to develop. This study aims to prepare RT loaded Chitosan Nanoparticles (RT-CS-NPs) develop and validate ultra-high performance liquid chromatography-electrospray ionization-synapt mass spectrometric method Synapt Mass Spectrometry (Synapt MS) (UHPLC/ESI-QTOF-MS/MS) for quantification of RT in brain homogenate from Wistar rat. The process of chromatographic separation was carried out on Waters ACQUITY UPLC™ with the components of separation in detail as; column: BEH C-18 with dimension as 2.1 mm×100 mm and particle size 1.7 µm, mobile phase: acetonitrile (85 % v/v/v): 2 mM ammonium formate (15 % v/v/v): formic acid (0.1 % v/v/v) and flow rate: 0.25 mL/min. Liquid-liquid extraction method (LLE), in mixture, i.e. ethyl acetate:acetonitrile, was considered to optimize the recovery of analyte from the brain homogenate of Wistar rat. Over a total run time of 5 minutes, the elution time for RT and internal standard (IS), i.e. Tolbutamide, observed was 2.67 and 2.82 min respectively whereas the transition observed for RT and IS was at m/z 611.1023/303.1071 and 271.1263/155.1073, respectively. Results, regarding various processes and parameters studied for RT as summarized, established a linear dynamic range over a concentration range of 1.00 ng/mL - 1000.0 ng/mL with r2; 0.9991±0.0010. Accuracy for intra and inter-assay in terms of % CV revealed a range of 0.45- 2.11 whereas lower limit of detection (LOD) and quantitation (LOQ) observed was 0.09 ng/mL and 0.142 ng/mL, respectively. The analyte stability as well as method specificity and accuracy, i.e. recovery > 86 %, supports the idea for application of current developed method in order to quantify and evaluate the RT-loaded-CS-NPs for RT determination in brain homogenate after intranasal drug delivery.
description: EXCLI Journal;Vol. 15, 2016
OSeMOSYS Kenya WESM - Documentation
Creators: name: Lubello, Pietro
name: Akute, Michelle
name: Pye, Steve
Publisher: name: Zenodo
Year: 2023

description: This repository contains the documentation in HTML format for the OSeMOSYS Whole Energy System Model developed for Kenya in the context of the Climate Compatible Growth project.This material has been produced with support from the Climate Compatible Growth (CCG) programme. CCG is funded by UK AID from the UK Government. Views expressed herein do not necessarily reflect the UK government's official policies.