title: ÐÐ¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð¼ÐµÐ¼Ð±ÑÐ°Ð½ Ð¼Ð¸ÐºÐ¾Ð±Ð°ÐºÑÐµÑÐ¸Ð¹ Ñ ÑÐµÐ»ÑÑ Ð¿Ð¾Ð¸ÑÐºÐ° Ð¸Ð½Ð½Ð¾Ð²Ð°ÑÐ¸Ð¾Ð½Ð½ÑÑ Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ð½ÑÑ ÑÑÐµÐ´ÑÑÐ²
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Modeling mycobacterial membranes to find innovative antitubercular agents
Creators: name: ÐÐ»Ð¾Ð´ÐµÐµÐ²Ð°, ÐÐ¾Ð»Ð¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: Ð»Ð¸Ð¿Ð¸Ð´Ð½ÑÐµ Ð±Ð¸ÑÐ»Ð¾Ð¸
Ð¼Ð¸ÐºÐ¾Ð»Ð¾Ð²ÑÐµ ÐºÐ¸ÑÐ»Ð¾ÑÑ
Ð³Ð»Ð¸ÐºÐ¾Ð»Ð¸Ð¿Ð¸Ð´Ñ
ÑÐ¸ÐºÐ»Ð¸ÑÐµÑÐºÐ¸Ðµ Ð»Ð¸Ð¿Ð¾Ð¿ÐµÐ¿ÑÐ¸Ð´Ñ
Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´Ð½ÑÐµ Ð¿Ð¸ÑÐ¸Ð¼Ð¸Ð´Ð¸Ð½Ð¾Ð²ÑÑ Ð½ÑÐºÐ»ÐµÐ¾Ð·Ð¸Ð´Ð¾Ð²
ÑÐ»Ð°Ð²Ð¾Ð½Ð¾Ð¸Ð´Ñ
lipid bilayers
mycolic acids
glycolipids
cyclic lipopeptides
pyrimidine nucleoside derivatives
flavonoids

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description: Purpose of work: to establish molecular mechanisms of action of potential antitubercular compounds in bilayers that mimic the inner and outer membranes of mycobacteria. The ion permeability of bilayers, mimicking the inner and outer membranes of mycobacteria, was measured at the adsorption of potential antitubercular agents and their influence on the density of lipid packing in the membrane was evaluated based on the measurement of the temperature and width of the main peak of lipid melting. It was found that phospholipid bilayer enrichment of the with methoxy- or ketomycolic acid or trehalose monooleate leads to a 2-4-fold decrease in the poreforming concentration of syringopeptin 22A. Flavonoids apigenin, naringenin, taxifolin, and quercetin were found to disorder membranes containing trehalose monooleate at concentrations an order of magnitude lower than bilayers not enrichment such components. The disordering effect of pyrimidine nucleoside derivatives, 5-alkyluridines, N4 -alkylcytidines, and 5-nor carbocyclic uracil derivatives, on lipid packing stress in the membrane was found to depend on the membrane-forming lipid and the type of nucleoside base. N4 -alkylcytidines have the greatest influence on the temperature and width of the phosphatidylcholine melting peak and the width of the main phase transition of phosphatidylglycerol. 5- alkyluridines form single ion-permeable pores in the phosphatidylglycerol membranes, while methoxymycolic acid and trehalose monooleate added to the lipid composition potentiate pore formation.