cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Ochthebius (Asiobates) orbus Perkins
Creators: name: Perkins, Philip D.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Hydraenidae
Ochthebius
Ochthebius orbus

description: Ochthebius (Asiobates) orbus Perkins
Ochthebius orbus Perkins 1980: 382
The new record below documents a new collection record and a new depository for identified specimens of this very rarely collected species, which is presently known only from Marin County, California and Portland, Oregon. Only four specimens of this species are in museum collections.
New record: U.S.A.: California, Marin Co., Mt. Tamalpais St. Pk., Redwood Creek, along Muir Woods Rd., 2 mi. S. Muir Woods N.M., 27.iii.1986, leg. C. B. Barr (1 female MCZ).
description: Published as part of Perkins, Philip D., 2023, New Neotropical and Nearctic species of water beetles in the genera Hydraena Kugelann and Ochthebius Leach, a key to North American genera and subgenera of the family, new distribution records, and a synopsis of ecology, behavior and morphology related to aquatic life (Coleoptera: Hydraenidae), pp. 1-86 in Zootaxa 5367 (1) on page 73, DOI: 10.11646/zootaxa.5367.1.1, http://zenodo.org/record/10145106
Blue Ridge Connections: A Youth Wellness Initiative
Creators: name: Garcia-Baza, Abigail
name: Nandyala, Anusha
name: Cogan, Alexandra
name: Bligen, E'Spreance
name: Eskandar, Christine
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description: Social and community contexts influence how individuals live (Healthy People 2030, n.d.). In Burke County, North Carolina, mental health and substance misuse rank as the top concerns with high overdose deaths between 2012 and 2019 (Burke Wellness Initiative, 2023). There is insufficient mental health and substance use support for adolescents (10-19 years old). “Blue Ridge Connections: A Youth Wellness Initiative” (BRCS) program, addresses these challenges by providing summer youth wellness and afterschool programs during the academic year. The engagement plan includes a diverse set of stakeholders, with a steering committee to develop visions and goals for successful initiatives. In the proposed solution, methods to foster planning and implementation, sustainability, and conflict resolution have been included for relevant stakeholders. Recommendations for the Burke County Commissioners are to continue forging partnerships with the public schools, healthcare providers, and key community youth leaders for the overall wellbeing of Burke County youth.
BindingDB Entry 50019643: Novel ACC Inhibitors for Treating Acne.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Acetyl-CoA carboxylase 1, Smith, Gambrell & Russell, Affinity

description: Small molecule binding data for protein Acetyl-CoA carboxylase 1, Uniprot Q13085
Ochthebius (Asiobates) similis Sharp
Creators: name: Perkins, Philip D.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Hydraenidae
Ochthebius
Ochthebius similis

description: Ochthebius (Asiobates) similis Sharp
Ochthebius similis Sharp, 1882:92
The new record below documents a new locality, the first for Chiapas, Mexico, for this very rarely collected species, raising the number of identified specimens in museum collections from 12 to 23. The species is presently known from Guatemala City, central Mexico, and central Arizona.
New record: Mexico: Chiapas, San Cristobal de las Casas (10 km S), 21.v.1981, leg. P. J. Spangler (11 NMNH).
description: Published as part of Perkins, Philip D., 2023, New Neotropical and Nearctic species of water beetles in the genera Hydraena Kugelann and Ochthebius Leach, a key to North American genera and subgenera of the family, new distribution records, and a synopsis of ecology, behavior and morphology related to aquatic life (Coleoptera: Hydraenidae), pp. 1-86 in Zootaxa 5367 (1) on page 73, DOI: 10.11646/zootaxa.5367.1.1, http://zenodo.org/record/10145106
Additional file 2: Table S2. of STAT3-mediated upregulation of lncRNA HOXD-AS1 as a ceRNA facilitates liver cancer metastasis by regulating SOX4
Creators: name: Wang, Hui
name: Xisong Huo
name: Yang, Xin-Rong
name: He, Jia
name: Lijun Cheng
name: Wang, Na
name: Deng, Xuan
name: Haojie Jin
name: Wang, Ning
name: Wang, Cun
name: Fangyu Zhao
name: Jingyuan Fang
name: Yao, Ming
name: Fan, Jia
name: Wenxin Qin
Publisher: name: Figshare
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Oligonucleotide sequences in this study. (DOCX 19Â kb)
BindingDB Entry 50019642: Imidazole Bioisostere Activators of Endopeptidase Neurolysin with Enhanced Potency and Metabolic Stability.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Neurolysin, mitochondrial, University of Nebraska Medical Center, Affinity

description: Small molecule binding data for protein Neurolysin, mitochondrial, Uniprot Q9BYT8
BindingDB Entry 50019641: Discovery of a New Class of 1-(4-Sulfamoylbenzoyl)piperidine-4-carboxamides as Human Carbonic Anhydrase Inhibitors.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Carbonic anhydrase 1, Carbonic anhydrase 12, Carbonic anhydrase 2, and Carbonic anhydrase 9, University of Cagliari, Affinity

description: Small molecule binding data for protein Carbonic anhydrase 1, Carbonic anhydrase 12, Carbonic anhydrase 2, and Carbonic anhydrase 9, Uniprot O43570, P00915, P00918, and Q16790
Ochthebius (Asiobates) angularidus Perkins
Creators: name: Perkins, Philip D.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Hydraenidae
Ochthebius
Ochthebius angularidus

description: Ochthebius (Asiobates) angularidus Perkins
Ochthebius angularidus Perkins 1980: 402
The following new records increases the number of specimens in collections from 27 to 49, and includes new museum depositories for the species. The known distribution area is small: northeastern Mexico and adjacent areas of Texas.
New records: U.S.A.: Texas, Baker’s Crossing, Devils River, 2.iv.2000, leg. E. G. Riley (19 TAMU); Jeff Davis Co., Davis Mts. Resort, upper Limpia Creek Cyn., (30°38’N, 104°8’W), 5.viii.2000, leg. E. G. Riley (2 TAMU); Real Co., Campground Creek at Hwy. 337, 5.5 mi. W. Campwood, 1.vi.1983, leg. C. B. Barr (1 MCZ).
description: Published as part of Perkins, Philip D., 2023, New Neotropical and Nearctic species of water beetles in the genera Hydraena Kugelann and Ochthebius Leach, a key to North American genera and subgenera of the family, new distribution records, and a synopsis of ecology, behavior and morphology related to aquatic life (Coleoptera: Hydraenidae), pp. 1-86 in Zootaxa 5367 (1) on page 73, DOI: 10.11646/zootaxa.5367.1.1, http://zenodo.org/record/10145106
Leptotrombidium (Leptotrombidium) koreanum
Creators: name: Nielsen, David H.
name: Robbins, Richard G.
name: Rueda, Leopoldo M.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Actinedida
Trombiculidae
Leptotrombidium
Leptotrombidium koreanum

description: Leptotrombidium (Leptotrombidium) koreanum (Vercammen-Grandjean and Langston, 1976):
PAL
Leptotrombidium (Leptotrombidium) russicum koreanum Vercammen-Grandjean and Langston, 1976
Leptotrombidium koreanum, Stekolnikov 2013 [5 group]
description: Published as part of Nielsen, David H., Robbins, Richard G. & Rueda, Leopoldo M., 2021, Annotated world checklist of the Trombiculidae and Leeuwenhoekiidae (1758 - 2021) (Acari: Trombiculoidea), with notes on nomenclature, taxonomy, and distribution, pp. 1-243 in Zootaxa 4967 (1) on page 132, DOI: 10.11646/zootaxa.4967.1.1, http://zenodo.org/record/4745510
Ochthebius (Asiobates) puncticollis LeConte
Creators: name: Perkins, Philip D.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Hydraenidae
Ochthebius
Ochthebius puncticollis

description: Ochthebius (Asiobates) puncticollis LeConte
(Fig. 38)
Ochthebius puncticollis LeConte, 1852: 210
The new records below document new localities and two new depositories for identified specimens of this species, which is widely distributed throughout the southwestern United States and adjacent Baja California. In California the species is apparently restricted to coastal mountain ranges; not yet known from the Sierra Nevada mountains.
New records: Mexico: Baja California, Norte, Isla Cedros north point, 20–21.iii.1981, leg. F. Andrews & D. Faulkner (30 CDFA); U.S.A.: Arizona, Navajo Co., Forestdale Trading Pst., 26.v.1979, leg. C. N. McKinnon (1 TAMU); Pinal Co., Aravaipa Primitive Ar., 27.v.1979, leg. C. N. McKinnon (2 TAMU); California, Orange Co., San Juan Canyon, 16.vii.1979, leg. C. N. McKinnon (2 TAMU).
description: Published as part of Perkins, Philip D., 2023, New Neotropical and Nearctic species of water beetles in the genera Hydraena Kugelann and Ochthebius Leach, a key to North American genera and subgenera of the family, new distribution records, and a synopsis of ecology, behavior and morphology related to aquatic life (Coleoptera: Hydraenidae), pp. 1-86 in Zootaxa 5367 (1) on page 73, DOI: 10.11646/zootaxa.5367.1.1, http://zenodo.org/record/10145106
BindingDB Entry 50019640: Discovery of α-Amidobenzylboronates as Highly Potent Covalent Inhibitors of Plasma Kallikrein.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: 26S proteasome regulatory subunit 6B, Coagulation factor XI, Coagulation factor XII, Plasma kallikrein, Plasminogen, and Platelet-derived growth factor receptor alpha/beta, University of Nottingham, Affinity

description: Small molecule binding data for protein 26S proteasome regulatory subunit 6B, Coagulation factor XI, Coagulation factor XII, Plasma kallikrein, Plasminogen, and Platelet-derived growth factor receptor alpha/beta, Uniprot P00747, P00748, P03951, P03952, P05622, P26618, and P43686
Ochthebius (Enicocerus) benefossus LeConte
Creators: name: Perkins, Philip D.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Hydraenidae
Ochthebius
Ochthebius benefossus

description: Ochthebius (Enicocerus) benefossus LeConte
(Fig. 38)
Ochthebius benefossus LeConte 1878: 381 This rarely collected species was formerly known from only 40 specimens, most of which have label data with only the state of collection, without any exact locality data or habitat data. Collecting in Massachusetts, New York and Vermont I discovered that this unusual species is hygropetric, found only in splash zones at the margins of waterfalls or on wet rocks, usually very large boulders. It is the only member of the subgenus in the New World, other species of the subgenus being found in Europe. It is also the only known strictly hygropetric Ochthebius in the New World. The known distribution is eastern North America from Quebec south to Virginia and west to Indiana.
New records (82 specimens): U.S.A.: Massachusetts, Hampden Co., Sanderson Brook, at base of Sanderson Brook Falls, (42°15’N, 72°57’W), 5.vii.2005, leg. M. E. and P. D. Perkins (20 MCZ); New York, Washington Co., Pumpkin Hook Creek, 4 mi. NE Cambridge on Chestnut Hill Rd., 30.vi.2003, leg. P. D. Perkins (4 MCZ); Vermont, Bennington Co., City Stream, 1 km S Woodford, (42°52’N, 73°4’W), 3.ix.2001, leg. M. E. and P. D. Perkins (40 MCZ); City Stream, 2 km SW Woodford (on hwy. 9), (42°52’N, 73°4’W), 23.viii.2001, leg. P. D. Perkins (2 MCZ); same locality, 3.ix.2001, leg. M. E. and P. D. Perkins (16 MCZ).
description: Published as part of Perkins, Philip D., 2023, New Neotropical and Nearctic species of water beetles in the genera Hydraena Kugelann and Ochthebius Leach, a key to North American genera and subgenera of the family, new distribution records, and a synopsis of ecology, behavior and morphology related to aquatic life (Coleoptera: Hydraenidae), pp. 1-86 in Zootaxa 5367 (1) on pages 73-74, DOI: 10.11646/zootaxa.5367.1.1, http://zenodo.org/record/10145106
BindingDB Entry 50019638: Novel PCSK9 Inhibitors for Treating Cardiovascular Diseases.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Proprotein convertase subtilisin/kexin type 9, Smith, Gambrell & Russell, Affinity

description: Small molecule binding data for protein Proprotein convertase subtilisin/kexin type 9, Uniprot Q8NBP7
Hebrus Curtis 1833
Creators: name: Stella, César Adrián
name: Pall, José Luis
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Hebridae
Hebrus

description: Genus Hebrus Curtis
1831 Hebrus Curtis, 199 [nomen nudum?], Curtis 1833, 198. Type species: Lygaeus pusillus Fallen, 1807. Designated by Kirkaldy, 1906.
1833 Naeogeus Laporte, 34. Type species: Naeogeus erythrocephalus Laporte, 1833 (= Hebrus pusillus Fallen, 1807). By monotypy.
description: Published as part of Stella, César Adrián & Pall, José Luis, 2018, A new species of Hebrus (Hemiptera: Heteroptera: Hebridae) from Argentina, pp. 474-480 in Zootaxa 4457 (3) on page 475, DOI: 10.11646/zootaxa.4457.3.9, http://zenodo.org/record/1457965
Blue Ridge Connections: A Youth Wellness Initiative
Creators: name: Christine Eskandar (E’Spreance Bligen, Alexandra Cogan, Abigail Garcia-Baza, Anusha Nandyala)
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description: ABSTRACT
E’Spreance Bligen, Alexandra Cogan, Christine Eskandar, Abigail Garcia-Baza, Anusha Nandyala: Blue Ridge Connections: A Youth Wellness Initiative
(Under the direction of W. Oscar Fleming)

Social and community contexts influence how individuals live (Healthy People 2030, n.d.). In Burke County, North Carolina, mental health and substance misuse rank as the top concerns, with high overdose deaths between 2012 and 2019 (Burke Wellness Initiative, 2023). There is insufficient mental health and substance use support for adolescents (10-19 years old). “Blue Ridge Connections: A Youth Wellness Initiative” (BRCS) program, addresses these challenges by providing summer youth wellness and afterschool programs during the academic year. The engagement plan includes a diverse set of stakeholders, with a steering committee to develop visions and goals for successful initiatives. In the proposed solution, methods to foster planning and implementation, sustainability, and conflict resolution have been included for relevant stakeholders. Recommendations for the Burke County Commissioners are to continue forging partnerships with the public schools, healthcare providers, and key community youth leaders for the overall well-being of Burke County youth.
 
Keywords: social and community context, mental health, substance misuse, schools, adolescents, BRCS
BindingDB Entry 50019637: Total Synthesis, Structure Reassignment, and Biological Evaluation of the Anti-Inflammatory Macrolactone 13-Hydroxy-14-deoxyoxacyclododecindione.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Mothers against decapentaplegic homolog 2 and Signal transducer and activator of transcription 6, Johannes Gutenberg-University, Affinity

description: Small molecule binding data for protein Mothers against decapentaplegic homolog 2 and Signal transducer and activator of transcription 6, Uniprot P42226 and Q15796
BLUE RIDGE CONNECTIONS: A YOUTH WELLNESS INITIATIVE
Creators: name: Nandyala, Anusha
name: Cogan, Alexandra
name: Garcia-Baza, Abigail
name: Eskandar, Christine
name: Bligen, E’Spreance
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description: Social and community contexts influence how individuals live (Healthy People 2030, n.d.). In Burke County, North Carolina, mental health and substance misuse rank as the top concerns with high overdose deaths between 2012 and 2019 (Burke Wellness Initiative, 2023). There is insufficient mental health and substance use support for adolescents (10-19 years old). “Blue Ridge Connections: A Youth Wellness Initiative” (BRCS) program, addresses these challenges by providing summer youth wellness and afterschool programs during the academic year. The engagement plan includes a diverse set of stakeholders, with a steering committee to develop visions and goals for successful initiatives. In the proposed solution, methods to foster planning and implementation, sustainability, and conflict resolution have been included for relevant stakeholders. Recommendations for the Burke County Commissioners are to continue forging partnerships with the public schools, healthcare providers, and key community youth leaders for the overall wellbeing of Burke County youth.
ХАВФЛИ ЙЎЛ БЎЛАКЛАРИНИ АНИҚЛАШДА СТАТИСТИК ВА ЗИДДИЯТЛИ ВАЗИЯТ УСУЛИ
Creators: name: Иргашев, Жавлонбек
Publisher: name: Zenodo
Year: 2024

description: Ушбу мақолада йўллардаги хавфли йўл бўлакларини аниқлашда статистик ва зиддиятли вазият усулини қўллаган ҳолда ЙТҲларнинг содир бўлиш сабаб-шароитларини ўрганилган бўлиб, соҳани такомиллаштиришга доир таклиф ва тавсиялар ишлаб чиқилган.
BindingDB Entry 50019636: Discovery of Clinical Candidate GLPG3970: A Potent and Selective Dual SIK2/SIK3 Inhibitor for the Treatment of Autoimmune and Inflammatory Diseases.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Cytochrome P450 1A2, Cytochrome P450 2C19, Cytochrome P450 2C9, Cytochrome P450 2D6, Cytochrome P450 3A4, Cytochrome P450 4B1, MAP kinase-interacting serine/threonine-protein kinase 2, Potassium voltage-gated channel subfamily H member 2, Receptor-interacting serine/threonine-protein kinase 2, Serine/threonine-protein kinase SIK1, Serine/threonine-protein kinase SIK2, Serine/threonine-protein kinase SIK3, and Tyrosine-protein kinase ABL1, Galapagos, Affinity

description: Small molecule binding data for protein Cytochrome P450 1A2, Cytochrome P450 2C19, Cytochrome P450 2C9, Cytochrome P450 2D6, Cytochrome P450 3A4, Cytochrome P450 4B1, MAP kinase-interacting serine/threonine-protein kinase 2, Potassium voltage-gated channel subfamily H member 2, Receptor-interacting serine/threonine-protein kinase 2, Serine/threonine-protein kinase SIK1, Serine/threonine-protein kinase SIK2, Serine/threonine-protein kinase SIK3, and Tyrosine-protein kinase ABL1, Uniprot O43353, P00519, P05177, P08684, P10635, P11712, P13584, P33261, P57059, Q12809, Q9H0K1, Q9HBH9, and Q9Y2K2
BindingDB Entry 50019634: Model of P-Glycoprotein Ligand Binding and Validation with Efflux Substrate Matched Pairs.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Mu-type opioid receptor, University of California, Affinity

description: Small molecule binding data for protein Mu-type opioid receptor, Uniprot P33535
BindingDB Entry 50019633: Discovery of GLPG2737, a Potent Type 2 Corrector of CFTR for the Treatment of Cystic Fibrosis in Combination with a Potentiator and a Type 1 Co-corrector.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Cystic fibrosis transmembrane conductance regulator, Cytochrome P450 1A2, Cytochrome P450 2C19, Cytochrome P450 2C9, Cytochrome P450 2D6, Cytochrome P450 3A4, Histamine H1 receptor, and Platelet-derived growth factor receptor alpha/beta, Galapagos, Affinity

description: Small molecule binding data for protein Cystic fibrosis transmembrane conductance regulator, Cytochrome P450 1A2, Cytochrome P450 2C19, Cytochrome P450 2C9, Cytochrome P450 2D6, Cytochrome P450 3A4, Histamine H1 receptor, and Platelet-derived growth factor receptor alpha/beta, Uniprot P05177, P05622, P08684, P10635, P11712, P13569, P26618, P33261, and P35367
Hebridae Amyot Serville 1843
Creators: name: Stella, César Adrián
name: Pall, José Luis
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Hebridae

description: Key to the species of Hebridae from Argentina
(Modified from Konopko et al. 2009)
1- Antenna with segments robust and thick (Fig.7); segment IV subequal in length to segment I.......... Merragata hebroides
- Antenna with segments slender; segment IV longer than segment I (Figs. 4, 8)..................................... 2
2- Antennal segment IV without constriction (Fig. 8); male with a subapical spine on the posterior surface of the hind tibia..................................................................................... Lipogomphus lacuniferus
- Antennal IV segment with a constriction in the middle (false membranous articulation), so that the antenna appears to possess five segments (Fig. 4); male lacking a subapical spine on the posterior surface of the hind tibia (Hebrus)................ 3
3- Body length approximately 3.00 mm; bucculae brownish, ventrally straight and subsequently slightly concave; clavus marked on each side with a small, basal, whitish spot adjacent to metanotal elevation and without pale spots on the membrane (Fig. 9). Metanotal elevation with lateral and hind margins carinate, with prominent median carina sharply obliquely narrowed on sides along apical two-fifths..................................................................... Hebrus engaeus
- Body length between 1.84 and 1.95 mm; bucculae yellowish, ventrally curved, posteriorly conical and slightly elevated; clavus with a pearl-white marking from the base until almost to the apex of the metanotal elevation (3/4 distance) and four distinct whitish spots on the membrane (Figs. 1, 2). Metanotal elevation with raised edges and strong, straight median carina, flanked by two submedial depressions....................................................... Hebrus alvearensis sp. nov.
description: Published as part of Stella, César Adrián & Pall, José Luis, 2018, A new species of Hebrus (Hemiptera: Heteroptera: Hebridae) from Argentina, pp. 474-480 in Zootaxa 4457 (3) on page 478, DOI: 10.11646/zootaxa.4457.3.9, http://zenodo.org/record/1457965
BindingDB Entry 50019632: Design, synthesis and preliminary biological evaluation of rivastigmine-INDY hybrids as multitarget ligands against Alzheimer's disease by targeting butyrylcholinesterase and DYRK1A/CLK1 kinases.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Acetylcholinesterase, Cholinesterase, Dual specificity protein kinase CLK1, and Dual specificity tyrosine-phosphorylation-regulated kinase 1A, University of Rouen Normandy, Affinity

description: Small molecule binding data for protein Acetylcholinesterase, Cholinesterase, Dual specificity protein kinase CLK1, and Dual specificity tyrosine-phosphorylation-regulated kinase 1A, Uniprot P22303, P49759, P81908, and Q13627
BindingDB Entry 50019631: Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Glucose-induced degradation protein 4 homolog, University of Toronto, Affinity

description: Small molecule binding data for protein Glucose-induced degradation protein 4 homolog, Uniprot Q8IVV7
Ochthebius (Gymnochthebius) nitidus LeConte
Creators: name: Perkins, Philip D.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Hydraenidae
Ochthebius
Ochthebius nitidus

description: Ochthebius (Gymnochthebius) nitidus LeConte
(Fig. 37)
Ochthebius nitidus LeConte, 1850: 217
The following collection/deposition data include the first records for Oklahoma, the southernmost known locality. The species distribution is principally trans-Canadian, northern and especially northeastern U.S.A., and south to Oklahoma. The data also include a new depository for identified specimens of this species.
New records: U.S.A.: Missouri, Boone, Ashland Wildlife Ar., 7.x.1976, leg. E. G. Riley (1 TAMU); same locality, 13.x.1976, leg. E. G. Riley (15 TAMU); Oklahoma, Latimer Co., 5 mi. W. Red Oak, 1.v.–1.xii.1980, leg. K. H. Stephan (5 MCZ); same locality, 1–30.v.1982, leg. K. H. Stephan (2 MCZ).
description: Published as part of Perkins, Philip D., 2023, New Neotropical and Nearctic species of water beetles in the genera Hydraena Kugelann and Ochthebius Leach, a key to North American genera and subgenera of the family, new distribution records, and a synopsis of ecology, behavior and morphology related to aquatic life (Coleoptera: Hydraenidae), pp. 1-86 in Zootaxa 5367 (1) on pages 75-76, DOI: 10.11646/zootaxa.5367.1.1, http://zenodo.org/record/10145106
BindingDB Entry 50019630: The medicinal chemistry evolution of antibody-drug conjugates.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2D6, Cytochrome P450 3A4, and Glucocorticoid receptor, Abbvi, Affinity

description: Small molecule binding data for protein Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2D6, Cytochrome P450 3A4, and Glucocorticoid receptor, Uniprot P04150, P05177, P08684, P10635, and P11712
Cyana (Strigivulpecula) naumanni Volynkin 2019, comb. nov.
Creators: name: Volynkin, Anton V.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Erebidae
Cyana

description: Cyana (Strigivulpecula) naumanni (Kühne, 2005), comb. nov. (Figs. 3–5)
Asura naumanni Kühne, 2005, Lambillionea, 105(3): 490, figs. 5, 6 (Type locality: “ Rwanda, Akagera riv, S Kibungo/Ibanda-Makera
... 2.17S, 30.47E ”).
Type material examined. Paratype (Fig. 3): ♂, Kenya, Western Prov., Kakamega Forest N.R., 2001–2003, ca. 0.21,3N; 34.51E, leg. L. Kühne / W Byango Hill 1600 m, 1.X.2002, light trap (12), 0.20,91N 34.51,71E / Paratypus ♂ Asura naumanni by: L. Kühne / Genitalia slide A. Volynkin 2017 AV2899 ♂ (Coll. ZMB).
Other material examined. UGANDA: 3 ♂, Uganda, Mpigi, Mpanga Forest, 25–30.XI.2014, LF, leg. W. Mey, slides AV4243 ♂, AV4244 ♂, AV4246 ♂ Volynkin (Coll. ZMB); 1 ♂, Uganda, Kibale National Park, Biol. Field Station, 19– 24.XI.2014, LF, leg. W. Mey, slide AV4245 ♂ Volynkin (Coll. ZMB); RWANDA: 2 ♂, Rwanda, Nyungwe NP 1800 m, 11 km N Uwinka, 2°25’S 29°09’E, 03.VIII.2008, leg. J. & W. De Prins, slide NHMUK010315262 Volynkin (Coll. NHMUK).
Note. During preparation of the original description, the holotype of C. naumanni from Rwanda (deposited in the private collection of Lars Kühne, Potsdam-Badelsberg, Germany) remained not dissected (Kühne 2005). Nevertheless, Mr Kühne kindly dissected it at my request and confirmed that it also has only two bunches of cornuti in its vesica.
Diagnosis. Forewing length is 10–11 mm in males. The species belongs to the subgenus Strigivulpecula Karisch, 2013 (Type species: Cyana rufeola Karisch & Dall’Asta, 2010) widespread in Afrotropics including Madagascar and the Comoro Islands and comprising seven valid species (Karisch 2013). Despite the species’ unusual wing coloration and pattern (Figs. 3–5), the male genitalia of C. naumanni (Figs. 11, 12) is very similar to that of C. (Strigivulpecula) nemasisha (Roesler, 1990) (Figs. 6, 13), but differ by its shorter cornuti of the distal diverticulum, stronger granulation of both diverticula, and the absence of a bunch of cornuti in the subbasal diverticulum.
Distribution. The species is known from Rwanda, Uganda and western Kenya (Kühne 2005).
description: Published as part of Volynkin, Anton V., 2019, Two new ' Asura - like' Cyana Walker, 1854 from Africa (Lepidoptera, Erebidae, Arctiinae), pp. 395-400 in Zootaxa 4576 (2) on pages 395-396, DOI: 10.11646/zootaxa.4576.2.13, http://zenodo.org/record/2624856
BindingDB Entry 50019629: Reinvestigation of diphenylmethylpiperazine analogues of pyrazine as new class of
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Cysteine proteinase falcipain 3 and Falcipain 2, Jamia Millia Islamia (A Central University), Affinity

description: Small molecule binding data for protein Cysteine proteinase falcipain 3 and Falcipain 2, Uniprot Q8IIL0 and Q9N6S8
BindingDB Entry 50019627: Terpenes and Terpenoids Conjugated with BODIPYs: An Overview of Biological and Chemical Properties.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Alpha-tocopherol transfer protein, Palacky University, Affinity

description: Small molecule binding data for protein Alpha-tocopherol transfer protein, Uniprot P49638
Ochthebius (Gymnochthebius) oppositus
Creators: name: Perkins, Philip D.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Hydraenidae
Ochthebius
Ochthebius oppositus

description: Ochthebius (Gymnochthebius) oppositus (Perkins)
(Fig. 37)
Gymnochthebius oppositus Perkins 1980: 290
This very rarely collected species was formerly known from only four specimens. The following 69 specimens comprise many new collecting records, new depository records, and new state records for Sinaloa, Mexico, and Louisiana, U.S.A. Currently known from disjunct localities: Mexico: Baja California, Sinaloa, Veracruz; U.S.A.: Louisiana, Texas.
New records: Mexico: Baja California, Norte, 2.1 mi. S Rosarito, 23.iii.1981, leg. F. Andrews & D. Faulkner (8 CDFA); Jalisco, 25 mi NW of Barra de Navidad, (19°28’N, 104°56’W), 22.vii.1974, leg. M. E. & P. D. Perkins (5 MCZ); Sinaloa, Mazatlan, 2.xii.1984, leg. G. E. Bohart (2 Albert Allen); U.S.A.: Louisiana, Cameron Parish, Rockefeller WMA, HQ, (29°43.762’N, 92°49.03’W), 3.ii.2009, leg. S.-R. Kang (2 LSU); same locality, 17.ii.2009, leg. S.-R. Kang (2 LSU); Texas, Chambers Co., Anahuac National Wildlike Refuge, 3 mi. SE Visitor Booth, 20.ix.1993, leg. R. C. Vogtsberger (10 TAMU (College Station)); Jefferson Co., J. D. Murphree Wildlife Management Area, 1.2 mi. S. Lost Lake, 29.iv.1995, leg. R. C. Vogtsberger (20 TAMU (College Station); J. D. Murphree Wildlife Management Area, near Lost Lake, (29°47’N, 93°58’W), 26.v.1994, leg. R. C. Vogtsberger (20 TAMU (College Station)).
description: Published as part of Perkins, Philip D., 2023, New Neotropical and Nearctic species of water beetles in the genera Hydraena Kugelann and Ochthebius Leach, a key to North American genera and subgenera of the family, new distribution records, and a synopsis of ecology, behavior and morphology related to aquatic life (Coleoptera: Hydraenidae), pp. 1-86 in Zootaxa 5367 (1) on page 76, DOI: 10.11646/zootaxa.5367.1.1, http://zenodo.org/record/10145106
BindingDB Entry 50019626: Development and
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Platelet-derived growth factor receptor alpha/beta and Programmed cell death 1 ligand 1, Cbmed, Affinity

description: Small molecule binding data for protein Platelet-derived growth factor receptor alpha/beta and Programmed cell death 1 ligand 1, Uniprot P05622, P26618, and Q9NZQ7
BindingDB Entry 50020895: Novel IRAK4 Inhibitors for Treating Asthma, COPD, Cancer, Autoinflammatory Diseases, and Autoimmune Diseases.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Interleukin-1 receptor-associated kinase 4, Smith, Gambrell & Russell, Affinity

description: Small molecule binding data for protein Interleukin-1 receptor-associated kinase 4, Uniprot Q69FE3 and Q9NWZ3
Cyana (Strigivulpecula) turlini Volynkin 2019, sp. nov.
Creators: name: Volynkin, Anton V.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Erebidae
Cyana

description: Cyana (Strigivulpecula) turlini sp. nov. (Figs. 1, 2, 9, 10)
urn:lsid:zoobank.org:act: 50B5240F-50A7-4493-AB11-31C0BA757735
Type material. Holotype (Figs. 1, 9): ♂, Rwanda, Nyungwe, 2000 m, K16, B. Turlin [leg.], 15.I. [19]77, slide ZSM Arct. 189/2017 A. Volynkin (Coll. ZSM).
Paratype: 1 ♂, Rwanda, Nyungwe, 2000 m, K6, B. Turlin [leg.], 23.X. [19]76, slide ZSM Arct. 223/2017 A. Volynkin (Coll. ZSM).
Etymology. The species name is dedicated to its collector, Bernard Turlin.
Diagnosis. Cyana turlini is externally very similar to its closest relative C. naumanni and they are probably sympatric, as both species were found in the same area (Nyungwe Forest). Externally, C. turlini (Figs. 1, 2) can be distinguished from C. naumanni (Figs. 3–5) by its broader forewings. The male genitalia of C. turlini (Figs. 9, 10) differ from that of C. naumanni (Figs. 11, 12) by the slightly broader vesica, the presence of a bunch of spike-like cornuti in the subbasal diverticulum of vesica, and the slightly shorter cornuti on both, medial and distal diverticula.
Description. Adult (Figs. 1, 2). Forewing length 11 mm in males. Body ochreous yellow with brown suffusion. Male antennae ciliate. Discal spots small, brown. Subbasal area ochreous yellow, sometimes with strong brown suffusion. Antemedial area brown. Medial area ochreous yellow. Postmedial area brown with pinkish suffusion outwards and ochreous yelow suffusion along the costa. Subterminal and terminal areas ochreous yellow. Cilia ochreous yellow. Hindwing pale ochreous yellow with weak pinkish suffusion, pattern absent. Male genitalia (Figs. 9, 10). Uncus broadly trigonal its basal part connected to tuba analis; tuba analis broad and membranous, subscaphium as field of weak granulation. Tegumen moderately elongated, narrow. Manica membranous; juxta broad, trapezoidal. Vinculum robust, U-shaped, with short elliptical saccus. Valva broad, medial costal angle well-developed; sacculus broad, its distal process broad, as long as distal section of valva, with short apical thorn. Aedeagus elongated, narrow, almost straight. Vesica with three diverticula: subbasal diverticulum short, with a bunch of spike-like cornuti of different size; medial diverticulum elongated, directed distally-dorsally, with weak granulation distally and bunch of spike-like cornuti of different size apically; distal diverticulum slightly shorter and broader than medial one, evenly granulated and has a bunch of spikelike cornuti of different size apically.
Female unknown.
Distribution. The new species is currently only known from its type locality, Nyungwe Forest in southwestern part of Rwanda.
description: Published as part of Volynkin, Anton V., 2019, Two new ' Asura - like' Cyana Walker, 1854 from Africa (Lepidoptera, Erebidae, Arctiinae), pp. 395-400 in Zootaxa 4576 (2) on page 396, DOI: 10.11646/zootaxa.4576.2.13, http://zenodo.org/record/2624856
BindingDB Entry 50020894: Discovery of 5-Azaquinoxaline Derivatives as Potent and Orally Bioavailable Allosteric SHP2 Inhibitors.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Platelet-derived growth factor receptor alpha/beta and Tyrosine-protein phosphatase non-receptor type 11, Pfizer, Affinity

description: Small molecule binding data for protein Platelet-derived growth factor receptor alpha/beta and Tyrosine-protein phosphatase non-receptor type 11, Uniprot P05622, P26618, and Q06124
Ochthebius arenicolus Perkins
Creators: name: Perkins, Philip D.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Hydraenidae
Ochthebius
Ochthebius arenicolus

description: Ochthebius (s.str.) arenicolus Perkins
Ochthebius arenicolus Perkins 1980: 506
The one new record given below is the first for an island off the California coast. This relatively commonly collected species is presently known from the coastal mountain ranges of southern Oregon, California, Baja California, and San Miguel Island.
New record: California: Santa Barbara Co., San Miguel Island, Waters Canyon, 23.v.1984, leg. S. E. Miller (1 MCZ).
description: Published as part of Perkins, Philip D., 2023, New Neotropical and Nearctic species of water beetles in the genera Hydraena Kugelann and Ochthebius Leach, a key to North American genera and subgenera of the family, new distribution records, and a synopsis of ecology, behavior and morphology related to aquatic life (Coleoptera: Hydraenidae), pp. 1-86 in Zootaxa 5367 (1) on page 76, DOI: 10.11646/zootaxa.5367.1.1, http://zenodo.org/record/10145106
BindingDB Entry 50020893: Discovery of a Novel Benzodiazepine Series of Cbl-b Inhibitors for the Enhancement of Antitumor Immunity.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: E3 ubiquitin-protein ligase CBL-B, Astrazeneca, Affinity

description: Small molecule binding data for protein E3 ubiquitin-protein ligase CBL-B, Uniprot Q13191
Leptotrombidium (Leptotrombidium) kulkarnii Vercammen-Grandjean and Langston 1976
Creators: name: Nielsen, David H.
name: Robbins, Richard G.
name: Rueda, Leopoldo M.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Actinedida
Trombiculidae
Leptotrombidium
Leptotrombidium kulkarnii

description: Leptotrombidium (Leptotrombidium) kulkarnii Vercammen-Grandjean and Langston, 1976:
ORI
Leptotrombidium (Leptotrombidium) delimushi kulkarnii Vercammen-Grandjean and Langston, 1976
Leptotrombidium (Leptotrombidium) kulkarnii, Vercammen-Grandjean & Langston 1976
Leptotrombidium kulkarnii, Stekolnikov 2013 [5 group]
description: Published as part of Nielsen, David H., Robbins, Richard G. & Rueda, Leopoldo M., 2021, Annotated world checklist of the Trombiculidae and Leeuwenhoekiidae (1758 - 2021) (Acari: Trombiculoidea), with notes on nomenclature, taxonomy, and distribution, pp. 1-243 in Zootaxa 4967 (1) on page 132, DOI: 10.11646/zootaxa.4967.1.1, http://zenodo.org/record/4745510
BindingDB Entry 50020892: Novel Fused Pyrazole Amide Analogs as Glucosylceramide Synthase Inhibitors for Treating Lysosomal Storage Diseases, Neurodegenerative Diseases, Cystic Diseases, and Cancer.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Ceramide glucosyltransferase, Smith, Gambrell & Russell, Affinity

description: Small molecule binding data for protein Ceramide glucosyltransferase, Uniprot Q16739
Ochthebius attritus LeConte
Creators: name: Perkins, Philip D.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Hydraenidae
Ochthebius
Ochthebius attritus

description: Ochthebius (s.str.) attritus LeConte
Ochthebius attritus LeConte 1878:380
The following new records represent first species deposition in two of the museums cited. This species is halophilic, with a wide distribution pattern; collection records are documented for the Antilles and mainland coastal areas of the Gulf of Mexico and the Caribbean Sea. Also known from one locality in easternmost Brazil.
New records: Dominican Republic: Pedernales, Cabo Rojo, 18–23.viii.1988, leg. M. A. Ivie, T. K. Philips, & K. A. Johnson (50 MCZ, MTEC (Bozeman)); Mexico: Guerrero, 17 mi. E. Acapulco, 9.vii.1974, leg. Clark, Murray, Ashe, Schaffner (20 TAMU (College Station)); Sinaloa, Mazatlan, 2.xii.1984, leg. G. E. Bohart (1 MCZ); U.S.A.: Texas, Jefferson Co., J. D. Murphree Wildlife Management Area, 1.2 mi. S. Lost Lake, 23.i.1994, leg. R. C. Vogtsberger & H. E. Bruhl (5 MCZ, TAMU (College Station)).
description: Published as part of Perkins, Philip D., 2023, New Neotropical and Nearctic species of water beetles in the genera Hydraena Kugelann and Ochthebius Leach, a key to North American genera and subgenera of the family, new distribution records, and a synopsis of ecology, behavior and morphology related to aquatic life (Coleoptera: Hydraenidae), pp. 1-86 in Zootaxa 5367 (1) on page 76, DOI: 10.11646/zootaxa.5367.1.1, http://zenodo.org/record/10145106
BindingDB Entry 50020890: 2-Amino-5-arylethynyl-thiophen-3-yl-(phenyl)methanones as A
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: 5-hydroxytryptamine receptor 7, Alpha-2A adrenergic receptor, Alpha-2B adrenergic receptor, Beta-3 adrenergic receptor, Sigma intracellular receptor 2, Sigma non-opioid intracellular receptor 1, and Translocator protein, National Institute of Diabetes and Digestive and Kidney Disease, Affinity

description: Small molecule binding data for protein 5-hydroxytryptamine receptor 7, Alpha-2A adrenergic receptor, Alpha-2B adrenergic receptor, Beta-3 adrenergic receptor, Sigma intracellular receptor 2, Sigma non-opioid intracellular receptor 1, and Translocator protein, Uniprot P08913, P13945, P18089, P30536, P34969, Q5BJF2, and Q99720
BindingDB Entry 50020888: Novel Indane-Containing NBTIs with Potent Anti-Gram-Negative Activity and Minimal hERG Inhibition.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Platelet-derived growth factor receptor alpha/beta, Roche Pharma Research & Early Development, Affinity

description: Small molecule binding data for protein Platelet-derived growth factor receptor alpha/beta, Uniprot P05622 and P26618
Additional file 3: Figure S1. of Validation of β-lactam minimum inhibitory concentration predictions for pneumococcal isolates with newly encountered penicillin binding protein (PBP) sequences
Creators: name: Li, Yuan
name: Metcalf, Benjamin
name: Sopio Chochua
name: Zhongya Li
name: Gertz, Robert
name: Walker, Hollis
name: Hawkins, Paulina
name: Tran, Theresa
name: McGee, Lesley
name: Beall, Bernard
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: A comparison of the Dataset1 (DS1, red) and Dataset2 (DS2, green) samples using t-SNE. Individual amino acid positions that were used to define PBP type were used as the starting dimensions. Figure S2. A randomization test of the “leave-one-type out” cross-validation. (A) The MIC labels were randomized over the input PBP sequences before the “leave-one-type out” cross-validation using the RF method. MIC values were log2 transformed and rounded to the nearest integer. Correlation between the true penicillin MIC (Log2_PEN) and predicted MIC (Log2_PEN_RANDtest) is shown. A small amount of random variation to the location of each point was added to aid visualization. Adjusted R2 from a linear regression are shown on top. (B) Results from the “leave-one-type out” cross-validation in which the true MIC labels were used. Figure S3. Log-log plot of the number of strains (nStrain) and the number of PBP types (nPT) for the 4309 strains and 417 PBP types observed in Dataset1 and Dataset2. Redline indicates the fitted line of a linear regression. R2 estimation of the linear regression are shown on top. Figure S4. Results from the bootstrap procedure for the power law model. The dashed-lines give approximate 95% confidence intervals. (PDF 324 kb)
BindingDB Entry 50020887: Targeted Protein Degradation of Histone Deacetylases by Hydrophobically Tagged Inhibitors.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Histone deacetylase 1, Histone deacetylase 2, Histone deacetylase 6, and Platelet-derived growth factor receptor alpha/beta, University of Bonn, Affinity

description: Small molecule binding data for protein Histone deacetylase 1, Histone deacetylase 2, Histone deacetylase 6, and Platelet-derived growth factor receptor alpha/beta, Uniprot P05622, P26618, Q13547, Q92769, and Q9UBN7
Ochthebius californicus Perkins
Creators: name: Perkins, Philip D.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Hydraenidae
Ochthebius
Ochthebius californicus

description: Ochthebius (s.str.) californicus Perkins
(Fig. 38)
Ochthebius californicus Perkins 1980: 338
The new records below document new localities and a new depository for identified specimens of this species, which is widely distributed throughout California; one locality is known from Carson City in westernmost Nevada.
New records: U.S.A.: California, Lake Success, 1.vii.1991, leg. W. F. Chamberlain (1 TAMU); Roseville, 3.vii.1991, leg. W. F. Chamberlain (1 TAMU); same locality, 20.vi.1993, leg. W. F. Chamberlain (1 TAMU);
description: Published as part of Perkins, Philip D., 2023, New Neotropical and Nearctic species of water beetles in the genera Hydraena Kugelann and Ochthebius Leach, a key to North American genera and subgenera of the family, new distribution records, and a synopsis of ecology, behavior and morphology related to aquatic life (Coleoptera: Hydraenidae), pp. 1-86 in Zootaxa 5367 (1) on page 77, DOI: 10.11646/zootaxa.5367.1.1, http://zenodo.org/record/10145106
BindingDB Entry 50020885: Discovery of Ligands for TRIM58, a Novel Tissue-Selective E3 Ligase.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: E3 ubiquitin-protein ligase TRIM58, Novartis Institutes for Biomedical Research, Affinity

description: Small molecule binding data for protein E3 ubiquitin-protein ligase TRIM58, Uniprot Q8NG06
BindingDB Entry 50020884: Phenyl-quinoline-xxo-butyric Acid Inhibitors of Histone Lysine Demethylase for the Treatment of Cancer.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Lysine-specific demethylase 4A and Lysine-specific demethylase 5B, Arrival Discovery, Affinity

description: Small molecule binding data for protein Lysine-specific demethylase 4A and Lysine-specific demethylase 5B, Uniprot O75164 and Q9UGL1
Additional file 3: Figure S1. of Validation of β-lactam minimum inhibitory concentration predictions for pneumococcal isolates with newly encountered penicillin binding protein (PBP) sequences
Creators: name: Li, Yuan
name: Metcalf, Benjamin
name: Sopio Chochua
name: Zhongya Li
name: Gertz, Robert
name: Walker, Hollis
name: Hawkins, Paulina
name: Tran, Theresa
name: McGee, Lesley
name: Beall, Bernard
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: A comparison of the Dataset1 (DS1, red) and Dataset2 (DS2, green) samples using t-SNE. Individual amino acid positions that were used to define PBP type were used as the starting dimensions. Figure S2. A randomization test of the “leave-one-type out” cross-validation. (A) The MIC labels were randomized over the input PBP sequences before the “leave-one-type out” cross-validation using the RF method. MIC values were log2 transformed and rounded to the nearest integer. Correlation between the true penicillin MIC (Log2_PEN) and predicted MIC (Log2_PEN_RANDtest) is shown. A small amount of random variation to the location of each point was added to aid visualization. Adjusted R2 from a linear regression are shown on top. (B) Results from the “leave-one-type out” cross-validation in which the true MIC labels were used. Figure S3. Log-log plot of the number of strains (nStrain) and the number of PBP types (nPT) for the 4309 strains and 417 PBP types observed in Dataset1 and Dataset2. Redline indicates the fitted line of a linear regression. R2 estimation of the linear regression are shown on top. Figure S4. Results from the bootstrap procedure for the power law model. The dashed-lines give approximate 95% confidence intervals. (PDF 324 kb)
BindingDB Entry 50020883: Discovery of Potent and Oral Bioavailable MAT2A Inhibitors for the Treatment of MTAP-Deleted Tumors.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: S-adenosylmethionine synthase isoform type-2, Hubei Bio-Pharmaceutical Industrial Technological Institute, Affinity

description: Small molecule binding data for protein S-adenosylmethionine synthase isoform type-2, Uniprot P31153