cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The effects of physicochemical wastewater treatment operations on forward osmosis
Creators: name: Hey, Tobias
name: Niada Bajraktari
name: Vogel, Jörg
name: Nielsen, Claus Hélix
name: Jansen, Jes La Cour
name: Jönsson, Karin
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Plant Biology

description: Raw municipal wastewater from a full-scale wastewater treatment plant was physicochemically pretreated in a large pilot-scale system comprising coagulation, flocculation, microsieve and microfiltration operated in various configurations. The produced microsieve filtrates and microfiltration permeates were then concentrated using forward osmosis (FO). Aquaporin InsideTM FO membranes were used for both the microsieve filtrate and microfiltration permeates, and Hydration Technologies Inc.–thin-film composite membranes for the microfiltration permeate using only NaCl as the draw solution. The FO performance was evaluated in terms of the water flux, water flux decline and solute rejections of biochemical oxygen demand, and total and soluble phosphorus. The obtained results were compared with the results of FO after only mechanical pretreatment. The FO permeates satisfied the Swedish discharge demands for small and medium-sized wastewater treatment plants. The study demonstrates that physicochemical pretreatment can improve the FO water flux by up to 20%. In contrast, the solute rejection decreases significantly compared to the FO-treated wastewater with mechanical pretreatment.
Serum heat shock protein concentrations are not associated with amyotrophic lateral sclerosis risk or survival in three European populations
Creators: name: Rooney, James P. K.
name: Geoghegan, Grainne
name: O’Reilly, Fiona
name: Heverin, Mark
name: Bose-O’Reilly, Stephan
name: Casale, Federico
name: Chio, Adriano
name: Günther, Kornelia
name: Schuster, Joachim
name: Klopstock, Thomas
name: Ludolph, Albert
name: Hardiman, Orla
name: Rakete, Stefan
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Introduction: Serum heat shock protein (HSP) concentrations have been reported as potential biomarkers for amyotrophic lateral sclerosis (ALS). Here, we investigate the role of serum HSP70, HSP90, and DNAJC7 as biomarkers for ALS. Methods: Serum samples were collected from ALS patients and volunteer controls from three different clinical cohorts (in Germany, Ireland, and Italy). Serum HSP concentrations were determined using enzyme-linked immunosorbent assay. Descriptive statistics, generalized logistic regression, and Cox proportional hazards models were used to model associations between log serum HSP concentrations and ALS risk. Results: In total, 251 ALS patients and 184 healthy volunteers were included. Logistic regression models failed to find associations between ALS risk and log serum concentration of HSP70 (OR 0.43, 95% CI: 0.10–1.78, p = 0.242), HSP90 (OR 0.95, 95% CI: 0.39–2.37, p = 0.904), or DNAJC7 (OR 1.55, 95% CI: 0.90–2.68, p = 0.118). Survival of ALS patients was not associated with log serum concentration of HSP HSP70 (HR1.06, 95% CI: 0.36–3.14, p = 0.916), HSP90 (HR 1.17, 95% CI: 0.67–2.02, p = 0.584), or DNAJC7 (HR 0.83, 95% CI: 0.57–1.21, p = 0.337). Discussion: We did not replicate previous findings that serum HSP70 and HSP90 concentrations were associated with risk of ALS. DNAJC7 was not associated with ALS risk, and there were no obvious longitudinal patterns in log serum concentrations of HSP70, HSP90, or DNAJC7. In addition, serum HSP concentrations were not associated with ALS survival.
Elucidating the Roles of GATA3 and IL-10 in the Development and Function of Natural Killer Cells During Murine Cytomegalovirus Infection
Creators: name: Ali, Alaa Kassim
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2020
Subjects: Natural killer cells (NK cells)
GATA3
Proliferation
Development
Maturation
MCMV
Immunoregulation
IL-10
Liver damage
Inflammation

description: Natural killer (NK) cells are lymphocytes of the innate immune system that exhibit cytotoxic functions against virus-infected cells and cancer cells. To achieve their complete functional capacity, NK cells need to differentiate through several stages of development. The maturation of NK cells is initiated in the bone marrow and is a prerequisite to equip the NK cell with migratory capabilities for the seeding of peripheral organs where they can protect the host. Several transcription factors have been shown to guide NK cell development. In this study, using NK cell-specific Gata3-deficient mice, I demonstrated that the transcription factor GATA3 plays an essential role in NK cell terminal differentiation required for bone marrow egress, resulting in decreased NK cell frequencies in the periphery at the steady-state. Despite the immature phenotype of NK cells in the absence of GATA3, these NK cells displayed enhanced proliferation during murine cytomegalovirus (MCMV) infection, indicating that immature NK cells are a reservoir of highly proliferative cytotoxic cells. Although numerous studies have demonstrated the critical role of NK cells in enhancing inflammatory responses through the production of pro-inflammatory cytokines such as IFNγ and TNFα, few studies have described the regulatory functions of NK cells. Using IL-10-GFP reporter mice, I showed that NK cells are major producers of the anti-inflammatory cytokine IL-10 during the early stages of MCMV infection, prompting further investigation into the contribution of NK cell-derived IL-10 on the inflammatory response against MCMV. Using NK cell-specific Il10-deficient mice, I demonstrated that NK cell-derived IL-10 regulates the function of CD4 and CD8 T cells in a model of sustained infection, and prevents liver damage, suggesting that NK cells produce IL-10 to limit immune-associated pathologies. These studies will advance our understanding of how NK cells develop and mediate their antiviral responses, while preventing host tissue damage.
title: Defining the intrinsic and innate immune response to UV irradiated HSV-1 infection
Creators: name: Iliev, Victor
Publisher: name: University of Glasgow
Year: 2022

description: Since the late 1960s UV irradiation of Herpesviruses has been used to study various aspects of cell biology, including the cellular immune response to virus infection. Previous studies have demonstrated that UV irradiation of herpesvirus virions strongly stimulates the type I and II IFN response to viral infection. However, the spatial and temporal kinetics of recruitment of immune signalling actuated in response to UV irradiated virus infection have remained poorly understood, due to limitations of viral DNA (vDNA) detection. Utilizing 5-Ethynyl-2’ deoxycytidine (EdC) labelling of HSV-1 DNA in combination with click chemistry, we were able to directly visualize vDNA and characterize the recruitment of host immune factors to infecting wild type (WT) or UV irradiated viral genomes. UV irradiation ofHSV-1 virions induced the premature cytoplasmic release of vDNA in a microtubule-dependent manner. An increase in vDNA thymine dimer formation was observed that restricted genome decompacting once released from the capsid. HSV-1 genomes in the cytoplasm exhibited an enhanced recruitment of cGAS and STING following UV irradiation compared to non-UV irradiated cytoplasmic genomes. Depletion of cGAS led to the loss of STING recruitment, demonstrating a sequential recruitment of cellular PRRs. ChIP analysis further supported this finding as cGAS interaction with HSV-1 genomes was enhanced following UV irradiation, whilst STING demonstrated no interaction at all. Conversely, UV irradiation reduced frequency of recruitment of key PML-NB proteins to vDNA in the nucleus. ChIP analysis demonstrated the interaction between UV irradiated vDNA and PML to be significantly reduced compared to WT HSV-1 genomes. The click labelling was further extended to human Cytomegalovirus (hCMV) to investigate if these immune defences are conserved among Herpesviruses or HSV-1 specific. Collectively, our analysis shows multiple host factors to alter their respective recruitment and/or vDNA binding properties in response to infection following UV irradiation.
HOW THE BRAIN MAY WORK
Creators: name: Bartlett, Karen
Publisher: name: figshare
Year: 2016
Subjects: subject: Anatomy
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Biophysics
subject: Medicine
subject: Neuroscience
subject: Physiology
subject: Applied Physics
subject: 29901 Biological Physics
subject: 29903 Medical Physics
subject: FOS: Physical sciences
subject: 20699 Quantum Physics not elsewhere classified
subject: Quantum Mechanics
subject: 20603 Quantum Information, Computation and Communication

description: The brain's functioning has always been a great mystery. Despite the remarkable progress of neuroscience since the 19th century, it remains a puzzle. While continued study of the nervous system is obviously absolutely essential to comprehending how the brain works, that alone may be insufficient. The input of other scientific disciplines appears necessary - studies like physics, holography, and even astronomy. Albert Einstein, one of the world's greatest physicists, regretted not making a bigger contribution to the medical sciences. Sixty years after his death, the time may be ripe for his theories to take part in revealing how the brain could conceive of wonders like the General Theory of Relativity.
Intro line:An interdisciplinary approach to the mystery of the brain - calling upon neuroscience, physics and astronomy.
Chinese prompts for the elicted sentences for group A
Creators: name: Sims, Nathaniel
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: subject: Northern Qiang (Mawo dialect)
subject: cng

description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
REVEALS—a longitudinal cohort study of multifaceted respiratory assessment in ALS
Creators: name: Rooney, James
name: Murray, Deirdre
name: Meldrum, Dara
name: Al-Chalabi, Ammar
name: Bunte, Tommy
name: Chiwera, Theresa
name: Choudhury, Mutahhara
name: Chio, Adriano
name: Fenton, Lauren
name: Fortune, Jennifer
name: Maidment, Lindsay
name: Manera, Umberto
name: McDermott, Christopher J.
name: Meyjes, Myrte
name: Tattersall, Rachel
name: Torrieri, Maria Claudia
name: Van Damme, Philip
name: Vanderlinden, Elien
name: Wood, Claire
name: van den Berg, Leonard H.
name: Hardiman, Orla
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Hematology

description: To systematically assess decline in respiratory measures in amyotrophic lateral sclerosis (ALS) and to examine the impact of sex, disease onset type and baseline morbidity on progression. The REVEALS study (Registry of Endpoints and Validated Experiences in ALS) was conducted between April 2018 and February 2021 in six European ALS centers. Slow and forced vital capacity (S/FVC), sniff nasal inspiratory pressure (SNIP), peak cough flow, amyotrophic lateral sclerosis functional rating scale-revised (ALSFRS-R), and respiratory morbidity were collected. Data were analyzed using a Bayesian multiple outcomes random effects model. Two hundred and eighty participants had a median of three assessments (IQR 2.0, 5.0) over a median of 8 months (IQR 2.3, 14.1). There were 974 data collection timepoints. Differences in respiratory measures and rates of decline between disease-onset and sex subgroups were identified. Females had lower scores in all respiratory measures and females with bulbar onset ALS had faster decline compared with other sub-groups. These differences were not detected by the ALSFRS-r respiratory subscale. Dyspnea, orthopnea, and a higher King’s stage at baseline were associated with lower respiratory scores throughout follow-up, while having a regular productive cough at baseline was associated with lower peak cough flow scores. Respiratory function declines more quickly in females with ALS compared with males when measured by FVC, SVC, SNIP, or PCF, but not the ALSFRS-R respiratory sub-score. Higher baseline King’s staging and the presence of clinical respiratory symptoms at baseline were associated with worse respiratory function. The ALSFRS-R respiratory sub-score is poorly correlated with objective respiratory measurements.
HOW THE BRAIN MAY WORK.doc
Creators: name: Bartlett, Karen
Publisher: name: figshare
Year: 2016
Subjects: subject: Anatomy
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Biophysics
subject: Medicine
subject: Neuroscience
subject: Physiology
subject: Applied Physics
subject: 29901 Biological Physics
subject: 29903 Medical Physics
subject: FOS: Physical sciences
subject: 20699 Quantum Physics not elsewhere classified
subject: Quantum Mechanics
subject: 20603 Quantum Information, Computation and Communication

description: The brain's functioning has always been a great mystery. Despite the remarkable progress of neuroscience since the 19th century, it remains a puzzle. While continued study of the nervous system is obviously absolutely essential to comprehending how the brain works, that alone may be insufficient. The input of other scientific disciplines appears necessary - studies like physics, holography, and even astronomy. Albert Einstein, one of the world's greatest physicists, regretted not making a bigger contribution to the medical sciences. Sixty years after his death, the time may be ripe for his theories to take part in revealing how the brain could conceive of wonders like the General Theory of Relativity.
Intro line:An interdisciplinary approach to the mystery of the brain - calling upon neuroscience, physics and astronomy.
Factors affecting anticipatory grief of family carers supporting people living with Motor Neurone disease: the impact of disease symptomatology
Creators: name: Trucco, Ana Paula
name: Khondoker, Mizanur
name: Kishita, Naoko
name: Backhouse, Tamara
name: Copsey, Helen
name: Mioshi, Eneida
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: To investigate the effect of carer- and disease-related factors on anticipatory grief (AG) in family carers supporting people living with Motor Neurone Disease. Seventy-five carers from the UK and USA participated in this cross-sectional study, between July 2021 and February 2023. Participants completed assessments on: anticipatory grief (MMCGI-SF, comprising three sub-scales: Personal Sacrifice Burden, Heartfelt Sadness and Longing, Worry and Felt Isolation); person with MND (pwMND) behavioral changes (MiND-B) and disease severity (ALSFRS-R); carer-pwMND emotional bond (Relationship Closeness Scale), familism levels (Familism Scale), and reported hours of care provided. Multiple linear regression analyses were conducted to explore factors impacting carer AG. AG total scores showed that 50.7% of carers were experiencing common grieving reactions, 22.6% presented intense grieving emotions, and 26.7% presented low grieving responses. Disease severity (regression coefficient, β = −0.31, p = 0.01, 95%CI −0.91 to −0.13) and behavioral changes (β = −0.34, p = 0.002, 95%CI −1.45 to −0.33) predicted AG total scores (proportion of explained variation, R2=0.38, p < 0.001). Regarding AG subscales, Personal Sacrifice Burden (R2=0.43, p < 0.001) was predicted by disease severity (β = −0.39, p < 0.001, 95%CI −0.42 to −0.11). Behavioral changes predicted Heartfelt Sadness and Longing (β = −0.27, p = 0.03, 95%CI −0.49 to −0.03; R2 = 0.21, p = 0.01) and Worry and Felt Isolation (β = −0.42, p < 0.001, 95%CI −0.63 to −0.20; R2=0.33, p < 0.001). This study suggests that disease-related factors may be the strongest predictors of carer AG. Interventions addressing carers’ understanding and management of MND symptoms seem crucial to support their experiences of loss and their acceptance of MND. Evidence-based support for carers in MND services is required.
Division by Zero Examples in Transmathematics v1.1
Creators: name: Gilreath, William
Publisher: name: figshare
Year: 2016
Subjects: subject: 10299 Applied Mathematics not elsewhere classified
subject: FOS: Mathematics

description: A research monograph in which three examples that illustrate why division by zero is frequently considered undefined operation are examined. The examples consider the unique case of zero divided by zero. Two examples are fallacies of equality, and the other is an example of ambiguity in the solution for an equation. These examples are examined using the transmathematic number nullity Φ. By utilizing nullity, division by zero is no longer an undefined or indeterminate operation, but a consistent, well-defined operation in arithmetic.
A novel TBK1 loss-of-function variant associated with ALS and parkinsonism phenotypes
Creators: name: Naruse, Hiroya
name: Iseki, Chifumi
name: Mitsui, Jun
name: Miki, Jun
name: Nagasawa, Hikaru
name: Kurokawa, Katsuro
name: Kobayashi, Ryota
name: Sato, Hiroyasu
name: Goto, Jun
name: Satake, Wataru
name: Ishiura, Hiroyuki
name: Tsuji, Shoji
name: Ohta, Yasuyuki
name: Toda, Tatsushi
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Environmental Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Loss-of-function (LoF) variants in the TANK binding kinase 1 (TBK1) gene are implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. In this study, we present the first familial cases of ALS and parkinsonism associated with a novel TBK1 variant. We describe two siblings: one diagnosed with classical ALS and the other with a unique syndrome overlapping ALS and parkinsonism. Comprehensive clinical and imaging evaluations supported these diagnoses. Genetic analysis through whole-genome sequencing revealed a previously unknown heterozygous splice site variant in TBK1. Functional assessments demonstrated that this splice site variant leads to abnormal splicing and subsequent degradation of the mutated TBK1 allele by nonsense-mediated decay, confirming its pathogenic impact. Our findings suggest a broader involvement of TBK1 in neurodegenerative diseases and underscore the need for further research into TBK1's role, advocating for screening for TBK1 variants in similar familial cases.
Division by Zero Examples in Transmathematics
Creators: name: Gilreath, William
Publisher: name: figshare
Year: 2016
Subjects: subject: 10299 Applied Mathematics not elsewhere classified
subject: FOS: Mathematics

description: A research monograph in which three examples that illustrate why division by zero is frequently considered undefined operation are examined. The examples consider the unique case of zero divided by zero. Two examples are fallacies of equality, and the other is an example of ambiguity in the solution for an equation. These examples are examined using the transmathematic number nullity Φ. By utilizing nullity, division by zero is no longer an undefined or indeterminate operation, but a consistent, well-defined operation in arithmetic.
title: Ð Ð°ÑÐ¸Ð¾Ð½Ð°Ð»ÑÐ½Ð°Ñ Ð´Ð¸ÐµÑÐ¾Ð»Ð¾Ð³Ð¸Ñ Ð¸ ÑÐ¿Ð¾ÑÑÐ¸Ð²Ð½ÑÐµ Ð´Ð¾Ð±Ð°Ð²ÐºÐ¸ Ð² Ð°ÑÐ¼ÑÐµÑÑÐ»Ð¸Ð½Ð³Ðµ
title: ÑÑÐµÐ±Ð½Ð¾Ðµ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ðµ
titleType: Subtitle
Creators: name: ÐÐ°ÑÐµÐµÐ²Ð°, ÐÐ¸Ð°Ð½Ð°
name: Ð¤Ð¾Ð¼Ð¸Ð½Ð°, ÐÐ²Ð³ÐµÐ½Ð¸Ñ
name: ÐÐ»Ð¾ÑÐ¸Ð½, Ð¡ÐµÑÐ³ÐµÐ¹
Publisher: name: ÐÐÐÐÐ¢ÐÐ¥-ÐÐ ÐÐ¡Ð¡
Year: 2023
Subjects: ÑÐ¸Ð·Ð¸ÑÐµÑÐºÐ°Ñ ÐºÑÐ»ÑÑÑÑÐ° Ð¸ ÑÐ¿Ð¾ÑÑ
Ð°ÑÐ¼ÑÐµÑÑÐ»Ð¸Ð½Ð³
Ð´Ð¸ÐµÑÐ¾Ð»Ð¾Ð³Ð¸Ñ
ÑÑÐµÐ±Ð½Ð¸ÐºÐ¸ Ð¸ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ñ Ð´Ð»Ñ Ð²ÑÐ·Ð¾Ð²

description: Ð£ÑÐµÐ±Ð½Ð¾Ðµ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ðµ Ð¿ÑÐµÐ´Ð¾ÑÑÐ°Ð²Ð»ÑÐµÑ Ð¸ÑÑÐµÑÐ¿ÑÐ²Ð°ÑÑÑÑ Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ñ Ð¾Ð± Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÑÑ ÑÐ¿Ð¾ÑÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð¿Ð¸ÑÐ°Ð½Ð¸Ñ Ð² Ð°ÑÐ¼ÑÐµÑÑÐ»Ð¸Ð½Ð³Ðµ, Ð¿Ð¾Ð·Ð²Ð¾Ð»ÑÐµÑ Ð½Ð°Ð³Ð»ÑÐ´Ð½Ð¾ Ð¿Ð¾Ð»ÑÑÐ¸ÑÑ Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ð¸Ðµ Ð¾ Ð½ÑÐ°Ð½ÑÐ°Ñ Ð¸ Ð±Ð°Ð·Ð¾Ð²ÑÑ Ð¿Ð¾Ð´ÑÐ¾Ð´Ð°Ñ Ðº Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐ¿ÐµÑÐ¸Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÑ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ¾Ð² Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸ Ð°ÐºÑÐ¸Ð²Ð½ÑÑ Ð´Ð¾Ð±Ð°Ð²Ð¾Ðº, Ð¼ÐµÐ´Ð¸ÐºÐ°Ð¼ÐµÐ½ÑÐ¾Ð² Ð² ÑÐµÐ»ÑÑ Ð¿ÑÐµÐ´Ð¾ÑÐ²ÑÐ°ÑÐµÐ½Ð¸Ñ Ð²Ð¾Ð·Ð½Ð¸ÐºÐ½Ð¾Ð²ÐµÐ½Ð¸Ñ ÑÑÐ°Ð²Ð¼Ð°ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐ¸Ð½Ð´ÑÐ¾Ð¼Ð° ÑÐ°Ð·Ð»Ð¸ÑÐ½Ð¾Ð¹ ÑÑÐ¸Ð¾Ð»Ð¾Ð³Ð¸Ð¸, Ð° ÑÐ°ÐºÐ¶Ðµ Ð¿Ð¾Ð´Ð´ÐµÑÐ¶Ð°Ð½Ð¸Ñ ÑÐ°Ð²Ð½Ð¾Ð²ÐµÑÐ½Ð¾Ð³Ð¾ ÑÐ¾ÑÑÐ¾ÑÐ½Ð¸Ñ ÑÐµÐ½ÑÑÐ°Ð»ÑÐ½Ð¾Ð¹ Ð½ÐµÑÐ²Ð½Ð¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ. ÐÐ¾Ð·Ð²Ð¾Ð»ÑÐµÑ ÑÐ¿Ð¾ÑÑÑÐ¼ÐµÐ½Ð°Ð¼ Ð½Ð° ÑÑÐ°Ð¿Ðµ Ð½Ð°ÑÐ°Ð»ÑÐ½Ð¾Ð³Ð¾ ÑÐ¿Ð¾ÑÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð¼Ð°ÑÑÐµÑÑÑÐ²Ð°, ÑÐ¶Ðµ ÑÑÐ¾Ð»ÐºÐ½ÑÐ²ÑÐ¸Ð¼ÑÑ Ñ ÑÑÐ´Ð¾Ð¼ ÑÐ¸Ð·Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ Ð¿ÑÐ¾Ð±Ð»ÐµÐ¼, Ð¿Ð¾Ð»ÑÑÐ¸ÑÑ Ð¿ÑÐ¾ÑÑÑÐµ Ð¸ Ð² ÑÐ¾ Ð¶Ðµ Ð²ÑÐµÐ¼Ñ ÑÑÑÐµÐºÑÐ¸Ð²Ð½ÑÐµ ÑÐµÑÐµÐ½Ð¸Ñ Ð´Ð»Ñ ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ñ Ð¸ Ð¿Ð¾Ð´Ð´ÐµÑÐ¶Ð°Ð½Ð¸Ñ ÑÑÐ½ÐºÑÐ¸Ð¾Ð½Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ ÑÐ¾ÑÑÐ¾ÑÐ½Ð¸Ñ Ð²ÑÑÐ¾ÐºÐ¾Ð¹ ÑÑÐµÐ¿ÐµÐ½Ð¸ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸.
ECAS correlation with metabolic alterations on FDG-PET imaging in ALS
Creators: name: Foucher, Juliette
name: Öijerstedt, Linn
name: Lovik, Anikó
name: Sun, Jiawei
name: Ismail, Muhammad-Al-Mustafa
name: Sennfält, Stefan
name: Savitcheva, Irina
name: Estenberg, Ulrika
name: Pagani, Marco
name: Fang, Fang
name: Pereira, Joana B.
name: Ingre, Caroline
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Chemical Sciences not elsewhere classified
subject: Mental Health
subject: Hematology
subject: Virology

description: Background: Cognitive impairment is observed in up to 50% of patients with amyotrophic lateral sclerosis (ALS). The Edinburgh Cognitive and Behavioral ALS Screen (ECAS) is an ALS-specific multi-domain screening tool. Few studies have examined the relationship between ECAS scores and [18F]fluorodeoxyglucose positron emission tomography ([18F]FDG-PET) findings. Objective: To assess the relationship between ECAS scores and glucose metabolism patterns on [18F]FDG -PET images in ALS. Methods: We collected [18F]FDG-PET images from 65 patients with ALS and 39 healthy controls. ECAS scores were collected on all patients and we calculated the correlation to [18F]FDG-PET in order to investigate the potential links between cognition and glucose metabolism. Results: We observed hypometabolism in the frontal cortex, insula, and limbic system, together with hypermetabolism in the cerebellum in patients with ALS compared to controls. A lower ECAS total score was associated with lower glucose metabolism in the right orbitofrontal gyrus and higher glucose metabolism in lateral occipital, medial occipital, and cerebellar regions, among patients with ALS. Similar results, although less widespread, were observed in the analyses of ECAS ALS-specific scores. Conclusions: The metabolic patterns in [18F]FDG -PET show that changes in the glucose metabolism of corresponding areas are related to cognitive dysfunction in ALS, and can be detected using the ECAS.
title: Table S1– Location (code), geographic coordinates, and the average depth of the 31 collection points sampled.
title: Table S1
titleType: Other
Creators: name: Vieira de Araujo, Fábio
name: Videla, Eduardo da Silva
name: Masi, Bruno Pereira
name: Carvalho da Silva, André Luiz
Publisher: name: Zenodo
Year: 2024

description: Supplementary table with data from the article "Subtidal benthic marine litter off the coast of Rio de Janeiro, Brazil" published in Ocean and Coastal Research
Chinese prompts for the elicted sentences for group B
Creators: name: Sims, Nathaniel
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: subject: Northern Qiang (Mawo dialect)
subject: cng

description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
Multivariate analysis of variance for functional data
Creators: name: T. Górecki
name: Ł. Smaga
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Functional data are being observed frequently in many scientific fields, and therefore most of the standard statistical methods are being adapted for functional data. The multivariate analysis of variance problem for functional data is considered. It seems to be of practical interest similarly as the one-way analysis of variance for such data. For the MANOVA problem for multivariate functional data, we propose permutation tests based on a basis function representation and tests based on random projections. Their performance is examined in comprehensive simulation studies, which provide an idea of the size control and power of the tests and identify differences between them. The simulation experiments are based on artificial data and real labeled multivariate time series data found in the literature. The results suggest that the studied testing procedures can detect small differences between vectors of curves even with small sample sizes. Illustrative real data examples of the use of the proposed testing procedures in practice are also presented.
title: 01_1606
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
eLearning integration in the library: A case study
Creators: name: Han, Yiye
name: Yates, Steven
Publisher: name: Monash University
Year: 2017
Subjects: subject: Library and Information Studies
subject: FOS: Media and communications

description: ABSTRACT Purpose Monash University Library has embraced eLearning as a strategy in its contribution to information research and learning skills development within the university. This paper describes an evaluation of the implementation of the strategy with recommendations for sustaining and improving practice.

Design/Methodology/Approach The evaluation is divided into four categories using a mixed methods methodology for evidence gathering. Quantitative and qualitative data is obtained from both primary and secondary sources for an enriched understanding of practices.

Findings Findings suggest that library staff have gained knowledge and skills indicating a sustainable strategy. However, further work is required to sustain staff development and support staff requirements in the long term.
Research limitations/implications This research is limited by its wide focus. Although this is mostly resolved through the use of multiple data collection methods, the thoroughness of the evaluation may have suffered while attempting to be comprehensive.
Practical implications The conclusions of this evaluation as well as methods of its execution can be shared with other institutions wishing to produce eLearning resources in a sustainable and effective manner.

Originality/value Monash University Library develops its eLearning resources in-house, whereas many other institutions outsource. The findings of this case study could be viewed as a positive indication of this in-house practice, which in turn might inform other organisations who are looking for a financially beneficial eLearning alternative.
Galaxy Formation Simulations in the MeerKAT Universe
Creators: name: Dave, Romeel
Publisher: name: Zenodo
Year: 2024

description: MeerKAT surveys of the extragalactic universe are revolutionising our view of galaxy evolution in the radio.  Galaxy formation simulations are vital for contextualising and interpreting the results within the modern multi-wavelength landscape, in order to provide constraints on the most uncertain aspects of galaxy evolution such as feedback and black hole growth.  I will describe how we are using our group's novel Simba simulation suite to explore galaxy evolution in the radio as seen with LADUMA, MIGHTEE, and other extragalactic surveys.  The combination of simulations with MeerKAT data has already yielded many new insights, as well as predictions that will be tested with upcoming programs.
title: Cultivating Innovation with Heart and Mind: Linking Team Compassion with Team Innovation through Team Integrative Complexity in the Developmental Phases of Team Innovation
Creators: name: Bui, Linh
Publisher: name: The Australian National University
Year: 2025

description: Teams engage in emotional experiences and regulate their cognitive processes at different developmental phases to foster team innovation. This research theorises and examines the role of team compassion, a unitary discrete emotion that arises from team members' shared experiences of witnessing others' needs or suffering, accompanied by a desire to help, in facilitating team innovation. Drawing on the teams-as-information-processors perspective, I argue that team compassion enhances team innovation by promoting team integrative complexity, wherein teams differentiate and integrate multiple dimensions and issues related to their tasks. Incorporating temporal views on teamwork, I posit that, compared to team integrative complexity in the early phase (when teams develop ideas) and midpoint transition (when teams redirect task strategies), team integrative complexity in the later phase (when teams implement ideas) is more likely to predict team innovation. In Study 1, using a sample of 87 organisational teams and a cross-lagged panel model in a longitudinal design, I found that team integrative complexity at Time 3 (i.e., later phase) mediated the effect of team compassion at Time 2 (i.e., midpoint transition) on team innovation at the end of innovative tasks (Time 4). Whereas team integrative complexity at Time 1 (i.e., early phase) and Time 2 were not significantly related to team innovation, the effect of team integrative complexity at Time 3 on team innovation was significant and positive. In Study 2, using a sample of 65 ad hoc teams and an experimental design, I manipulated team compassion and observed team integrative complexity at three phases of a team's life. I found that teams in the team compassion condition produced higher levels of team integrative complexity than those in the control condition. In turn, team integrative complexity enhanced team innovation. Team integrative complexity in the later phase was more likely to correspond to achieving team innovation than it was during the early phase and midpoint transition. Implications for theories, practice, and future research are discussed.
Chinese prompts for the elicted sentences for group C
Creators: name: Sims, Nathaniel
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: subject: Northern Qiang (Mawo dialect)
subject: cng

description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
Design Optimization of a Motorbike Swing Arm Using Generative Design
Creators: name: Aryan Raval, Amit Dangodara, Manav Mandiwala,Vishal Dagra, Sunny patel, Smit Brahmkshatriya
Publisher: name: Zenodo
Year: 2024

description: This study delves into design optimization process using generative design as the optimization method. The objective of this study is to achieve a refined swing arm design which goes through mass reduction while withstanding the forces that could be acting upon in real world load cases. For this particular study generative design capabilities of Autodesk Fusion 360 are employed, which creates numerous iterations of possible design which might serve as inspiration for the final design by using user defined loads and geometrical as well as dimensional constraints.
Table S2 : Number of items distributed in each type of material within each category The separation of these materials within each category sought to consider the type of use when possible.
Creators: name: Vieira de Araujo, Fábio
name: Videla, Eduardo da Silva
name: Masi, Bruno Pereira
name: Carvalho da Silva, André Luiz
Publisher: name: Zenodo
Year: 2024

description: Supplementary table with data from the article "Subtidal benthic marine litter off the coast of Rio de Janeiro, Brazil" published in Ocean and Coastal Research
Analysis of metabolic compounds and antitumorigenic effects of Albizia niopoides and Senegalia polyphylla leaves
Creators: name: Pereira, Thalissa Cagnin
name: Cardoso, Luana Pereira
name: de Paiva, Wesller da Silva
name: de Camargos, Liliane Santos
name: Rodrigues-Lisoni, Flávia Cristina
name: Martins, Aline Redondo
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Hematology
subject: Plant Biology
subject: Virology

description: The objective of this study was to quantify metabolic compounds in leaves of A. niopoides and S. polyphylla and to evaluate the antitumor potential of extracts from both species in cervical tumour cells. The physiological analyses performed were quantification of starch, sucrose, phenolic compounds and proteins. An aqueous extract was prepared and added to the SiHa cell line at concentrations of 10, 100 and 1000 μg/mL at 4h, 24h, 48h and 72h. Cell morphology, proliferation and viability were analysed. The species showed a large amount of starch and phenolic compounds. Treatment with the extract of both species caused morphological changes in SiHa cells and exhibited antiproliferative effects at a concentration of 1000 µg/ml. In cell viability test, only A. niopoides showed a significant reduction. The study presented the effects of the species against a cervical cancer cell line, where A. niopoides has already shown to be a promising plant drug.
Serum proteomics analysis of drug-naïve patients with generalised anxiety disorder: Tandem mass tags and multiple reaction monitoring
Creators: name: Li, Xue
name: Zheng, Sisi
name: Feng, Zhengtian
name: Liu, Xinzi
name: Ding, Ying
name: Zhang, Lina
name: Zhang, Guofu
name: Liu, Min
name: Zhu, Hong
name: Jia, Hongxiao
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: The prevalence of generalised anxiety disorder (GAD) is high. However, the underlying mechanisms remain elusive. Proteomics techniques can be employed to assess the pathological mechanisms involved in GAD. Twenty-two drug-naive GAD patients were recruited, their serum samples were used for protein quantification and identified using Tandem Mass Tag and Multiple Reaction Monitoring (MRM). Machine learning models were employed to construct predictive models for disease occurrence by using clinical scores and target proteins as input variables. A total of 991 proteins were differentially expressed between GAD and healthy participants. Gene Ontology analysis revealed that these proteins were significantly associated with stress response and biological regulation, suggesting a significant implication in anxiety disorders. MRM validation revealed evident disparities in 12 specific proteins. The machine learning model found a set of five proteins accurately predicting the occurrence of the disease at a rate of 87.5%, such as alpha 1B-glycoprotein, complement component 4 A, transferrin, V3-3, and defensin alpha 1. These proteins had a functional association with immune inflammation. The development of generalised anxiety disorder might be closely linked to the immune inflammatory stress response.
Organising tourism providers on remote touring tracks as geographically distributed teams
Creators: name: Cartan, Gregory
Publisher: name: Charles Darwin University
Year: 2013

description: This study explains the organisation of tourism providers on remote touring tracks (RTT) as geographically distributed teams (GDTs). The GDT framework adopted comprised seven elements: geographic dispersion, information and communication technologies (ICTs), team membership, cultural diversity, shared mindset, collaboration, and leadership. An inputs-processes-outcomes (I-P-O) model was adopted to configure the elements of the GDT framework and to highlight their dynamic and interdependent nature. A case study research design was adopted. Two similar cases, the Gunbarrel Highway and the Oodnadatta Track were chosen. Data were collected using internet mediated research (IMR) and a field study involving interviews, on-site observations and documentation collation. The elements of the GDT framework were used as codes for classifying data. A cross case analysis provided an integrated picture of both sites. The results present a rich description of the organisation of tourism providers on RTTs, characterised by remoteness, disconnectedness, and significant degrees of geographic dispersion. The results also indicated a nucleus of capability associated with each element of the GDT framework. This capability was underdeveloped but offered latent potential. Leadership emerged as a pivotal element. The utility of the GDT lens as a diagnostic framework and as a prognostic tool was affirmed. This study makes important contributions to both theory and practice. The use of GDTs as a theoretical lens to better understand RTTs adds a fresh dimension to the analysis of remote tourism destinations. By conceptualising tourism providers as a team, the focus expands to encompass the synergy produced by the collective of tourism providers in addition to individual contributions. The study is of practical significance to tourism providers on RTTs, as it provides insight into the practical functioning of these destinations. It also identifies and classifies tourism providers, their locations and how they interact. These insights have the potential to assist tourism providers reflect on current practice and consider future possibilities.
title: 'We Will Stay in the Indian Ocean': The British Indian Ocean Territory, 1965-91
Creators: name: Bashfield, Samuel
Publisher: name: The Australian National University
Year: 2025

description: While Britain decolonised its global empire in the post-Second World War period, one more colony was mysteriously, surreptitiously and illegally created in 1965 - the British Indian Ocean Territory (BIOT). Ostensibly, BIOT was created to house a humble Anglo/US military communications station on the largest island of Diego Garcia, strategically located in the centre of the Indian Ocean. However, BIOT's strategic utility went far beyond secure military communications. Put simply, BIOT was created to facilitate a Cold War transfer of hegemonic power from the United Kingdom to the United States, and to perpetuate Western power in the Indian Ocean Region and Middle East. This historical dissertation examines British and American interests in BIOT between 1965 and the Cold War's end. Its chapters illuminate how respective Anglo-US defence strategies shaped BIOT's militarisation, how BIOT was used to slow Britain's withdrawal 'East of Suez,' how Britain used BIOT to entrench the US in the Indian Ocean, how Britain used BIOT to attain discounted submarine-launched ballistic missiles across three separate deals, and lastly, how dissenting regional states were rebuffed. Diego Garcia did not become one of the West's most critical overseas bases haphazardly but was painstakingly selected and cultivated throughout the Cold War as a linchpin of Western predominance, no matter the considerable political costs. Using recently declassified American, British and Australian archives, this project sheds light on how BIOT was selected, militarised, transacted and defended from its creation through to the Cold War's end.
The Discovery of the Periodic Table.pdf
Creators: name: Forrester, Rochelle
Publisher: name: figshare
Year: 2016
Subjects: subject: History
subject: Sociology
subject: FOS: Sociology
subject: Uncategorized

description: This paper was written to investigate the order of discoveries made in chemistry up to the discovery of the periodic table. New experimental techniques such as the pneumatic trough, voltaic piles, spectroscopy and potassium analysis led to the discovery of many new elements and their properties which enabled the discovery of the periodic table. The discoveries led to the demise of the classical theory of the elements, to the end of the phlogiston theory, and to the creation of the modern ideas of the elements and of the atomic theory. The paper shows the discoveries were made in a necessary and inevitable order with new experimental techniques leading to the discovery of new elements which eventually led to the discovery of the periodic table.
HOZIRGI ZAMON PSIXOLOGIYASI VA UNING TURLARI
Creators: name: Abdusattarova, Zilola
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqolada maktab, universitit, kasb –hunar maktabi o‘quvchi va talabalariga hozirgi zamon psixologiyasi haqida tushuncha berib o‘tilgan. Hozirgi zamon psixologiyasi fanining tuzilishi, uning asosiy tarmoqlari. Psixologiya fanining ilmiy tekshirish metodlari haqida ma’lumotlarga ega bo‘lasiz.
BioClocksUK Newsletter 1st Edition
Creators: name: Valdivia-Cabrera, Marissa
name: Dodd, Antony
name: BioClocksUK
Publisher: name: Zenodo
Year: 2024

description: BioClocksUK Newsletter 1st Edition

Edited by Prof. Antony Dodd

Compiled by Dr. Marissa Valdivia-Cabrera

BioClocksUK graphics by Dr. Nina Rzechorzek

Special acknowledgment to all contributors and to the BioClocksUK volunteers.

Funder: The Royal Society of Edinburgh
PEDAGOGIKA SOHASIDA PSIXOLOGIYANING O'RNI
Creators: name: Husniddinova, Diyora
Publisher: name: Zenodo
Year: 2024

description: ushbu maqola pedagog ya’ni o‘qituvchilar uchun psixologiya sohasining qanchalik kerak ekanligi va bu sohaning ta’limdagi ahamiyati haqida yoritib beriladi.
Topologie-Optimierung eines radselektiv angesteuerten Fahrzeugs basierend auf einer optimalen Fahrzeugführungsregelung
Creators: name: Schwartz, Manuel
Publisher: name: Karlsruher Institut für Technologie (KIT)
Year: 2022

description: Die Elektrifizierung des Antriebsstrangs und zunehmende Automatisierung personenbefördernder Fahrzeuge fördern Innovationen der gesamten Fahrzeugarchitektur. Im Automobilbereich werden zwei relevante Entwicklungsrichtungen angestrebt. Zum einen steht die Reduzierung der durch den Straßenverkehr hervorgerufenen CO₂-Emissionen im Fokus. Zusätzlich führt der zunehmende Automatisierungsgrad aktueller Serienfahrzeuge zur Erhöhung der Fahrsicherheit und des Fahrkomforts. Werden weiterhin radselektiv gelenkte und angetriebene Fahrzeuge betrachtet können Herausforderungen dicht besiedelter urbaner Regionen, durch die erhöhte Manövrierbarkeit solcher Fahrzeuge, begegnet werden. Um diese Entwicklungschwerpunkte sowie das alternative Fahrzeugkonzept zusammenzuführen, wird in dieser Arbeit die Frage beantwortet, wie ein optimales Fahrwerk, basierend auf der Betrachtung der aktorischen Freiheitsgrade eines radselektiv angesteuerten Fahrzeugs, zu gestalten ist. Dabei wird die Auslegung des Arbeitsbereichs der Radmodule sowie deren Anbcindung an die Karosserie durch Definition der kinematischen Kennwerte mit einem vorgestellten Auslegungserfahren durchgeführt und anschließend analysiert. Die Topologie-Optimierung einer virtuellen Radaufhängung erfolgt im Zusammenspiel mit einer durchgängigen, optimalen Fahrzeugführungsregelung, wodurch die Freiheitsgrade des Fahrzeugkonzepts auch Einfluss auf den Entwurf des Fahrwerks haben. Dabei wird das radselektiv gelenkte und angetriebene, automatisiert geführte Fahrzeug energieoptimal angesteuert sowie die erhöhte Manövrierfähigkeit des Konzeptes ausgenutzt. Die Arbeit ist in zwei grundlegende Beiträge unterteilt. Zunächst ist dies der Entwurf einer durchgängigen Fahrzeugführungsregelung für das radselektiv angesteuerte Fahrzeug. Zwischen den Schnittstellen zum Trajektorien-Planer sowie den Elektromotoren der Antriebe erfolgt eine kaskadierte, prädiktive und lokal optimale Regelung des Fahrzeugs. Hierbei wird der Soll-Arbeitsbereich durch die optimale Ausnutzung der Fahrzeugführungsfreiheitsgrade durch die Regelungsarchitektur und -strategie zur Laufzeit und ohne Geschwindigkeitsbeschränkungen festgelegt. Im zweiten Teil der Arbeit wird diese Regelung zusammen mit einem detaillierten Fahrzeugmodell als Black-Box-Simulation innerhalb einer Topologie-Optimierung basierend auf evolutionären Algorithmen eingebettet. Kinematische Zusammenhänge des Fahrwerks, abgebildet über virtuelle Lenker und Drehpole der Radaufhängung, werden bei dem vorgestellten Auslegungsverfahren als Optimierungsparameter zur globalen Optimierung des Fahrzeugverhaltens hinsichtlich des Energieverbrauchs sowie der Fahrkomfortsteigerung ausgelegt.