cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Representation of and coping with osteoarthritis among older Koreans in the United States
Creators: name: Choi, Yeon-Ah
Publisher: name: University of Utah
Year: 2012
Subjects: United States
Koreans

description: Osteoarthritis (OA) is the most prevalent chronic disease affecting older people and a major cause of disability and utilization of healthcare resources. Coping and self-management behaviors may have a decisive impact on the physical, psychological, and social outcomes of experience with OA. The purpose of this study was to describe the process and pattern of OA representation, coping, and its impacts among older Koreans in the United States. This study employed an exploratory descriptive design. Data were collected using a semistructured interview method. Participants of the study were 18 older Koreans living in southern California. The findings of the study indicated that representation, coping, and coping appraisal were interconnected concepts in the management of OA. Participants' representation was categorized into symptoms, name, cause and cure of their illness, and concerns for the future. Coping with OA included seeking healthcare providers, using folk remedies, exercising, controlling the mind, praying, comparing to others, accepting destiny, and developing their own healing methods. Participants evaluated the process and outcome of coping and reset their treatment goals. OA affects older Koreans' daily living, financial status, family relationships, social activities, and perceptions of life. Older Koreans were very familiar with OA even before they experienced any initial symptoms. They believed that OA was an incurable, painful illness that caused difficulties in their daily lives and tremendous financial burdens. They were concerned about becoming a burden on their families in the future. They tried most treatments suggested by friends and families and finally adopted or developed their own healing methods. They accepted OA as their destiny, and they were living with it. They were still happy because they were loved and cared for by their family, friends, church, and God. The major significance of the study is its contribution to understanding health behavior among older Koreans in the United States. It is important to provide nursing care in a manner that respects the individuality of each client who has unique life experiences and cultural backgrounds.
Additional file 1 of Development of a new model on utilizing online learning platforms to improve students’ academic achievements and satisfaction
Creators: name: Abuhassna, Hassan
name: Al-Rahmi, Waleed Mugahed
name: Noraffandy Yahya
name: Megat Aman Zahiri Megat Zakaria
name: Azlina Bt. Mohd Kosnin
name: Darwish, Mohamad
Publisher: name: figshare
Year: 2020
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file 1. General objective of the study
A mathematical investigation of the innate and adaptive immune surveillance of tumor growth
Creators: name: Quinonez, Jonathan Alexander
Publisher: name: University of Utah
Year: 2012

description: Mathematical models of tumor-immune interactions provide an analytical framework by which to address specific questions about tumor-immune dynamics. We present an extension of a mathematical model developed by De Pillis et al. that accounts for the immune surveillance of tumors by natural killer (NK) cells and cytotoxic CD8+ T lymphocytes (CTL's). NK cells mediate an innate immune response against cancer because NK cells can respond to tumor cells without the need for prior antigen-specific stimulation, while CTL's mediate an adaptive immune response because they require antigen-specific stimulation before responding effectively. Our extended model incorporates state transitions between naive and primed CTL's and cytokine signaling between NK cells and CTL's. In addition, the model describes tumor-immune interactions focusing on the roles of the innate and adaptive immune responses in tumor immune surveillance. The mathematical model describes tumor-immune interactions by utilizing a system of non-linear differential equations with respect to tumor cells, NK cells, CTL's, and antigen presenting cells. The functions describing tumor-immune growth, antigen presentation, immune response, and interaction rates are numerically simulated with a differential equation solver (GNU Octave). Parameter estimates and model validations are obtained from prior mathematical papers and medical studies related to this topic. We expect that both the innate and adaptive immune systems play independent and synergistic roles to defend the body from cancer.
Antiviral activity of amides and carboxamides of quinolizidine alkaloid (−)-cytisine against human influenza virus A (H1N1) and parainfluenza virus type 3
Creators: name: Fedorova, Victoria A.
name: Kadyrova, Renata A.
name: Slita, Alexander V.
name: Muryleva, Anna A.
name: Petrova, Polina R.
name: Kovalskaya, Alena V.
name: Lobov, Alexander N.
name: Zileeva, Zulfiya R.
name: Tsypyshev, Dmiry O.
name: Borisevich, Sophia S.
name: Tsypysheva, Inna P.
name: Vakhitova, Julia V.
name: Zarubaev, Vladimir V.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: Novel derivatives of quinolizidine alkaloid (−)-cytisine were synthesised. ADME properties, cytotoxicity against HEK293 cells and activity against viruses of influenza A/California/07/09(H1N1)pdm09 virus (IAV) and human parainfluenza virus type 3 (HPIV3) were evaluated. It was shown, that 9-carboxamides of methylcytisine (with phenyl and allyl urea’s fragments) are most active compounds against IAV probably due to predicted in silico peculiarity of their interactions with the 4R7B active site of IAV neuraminidase. Indexes of selectivity (SI) calculated as ratio of CC50/IC50 of these ureas are 47 and 59 correspondingly. It was also found, that derivatives obtained from allyl isocyanate and (−)-cytisine or 9,11-dibromocytisine are able to inhibit a reproduction of HPIV3 with SI = 58 and 95. Moreover, last compound - (1 R,5R)-N-allyl-9,11-dibromo-8-oxo-1,5,6,8-tetrahydro-2H-1,5-methanopyrido[1,2-a][1,5]diazocine-3(4H)-carboxamide with two bromine atom in 2-pyridone core of starting (−)-cytisine molecule, demonstrated high activity against HPIV3 (SI = 95) and moderate activity against IAV (SI = 16).
Brief an [Daniel I Bernoulli]
Creators: name: Fuss, Nikolaj I.
Publisher: name: [s.n.]
Year: 1776
Subjects: Brouncker, William1620-1684
Euler, Leonhard1707-1783
Leibniz, Gottfried Wilhelm1646-1716

description: von N[iklaus] Fuss
description: Am Briefkopf "F.V."
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Datenimport aus LIDOS / Bernoulli (2004-07-02)
Comprehensive breast cancer knowledge test : validity and reliability
Creators: name: Stager, Jennifer Lou
Publisher: name: University of Utah
Year: 2012
Subjects: Mass Screening
Research Design
Risk Factors

description: Two subscales for a breast cancer knowledge test were developed and tested to be used (a) in determining a woman's general knowledge of breast cancer (i.e., risk factors and epidemiology) and her knowledge of breast cancer curability, and (b) in exploring the relationship between knowledge of breast cancer and utilization of screening practices.  These subscales were designed to be used in conjunction with the Breast Cancer Knowledge Test (BCKT), which assesses screening and detection knowledge.  The instrument was submitted to four experts in the field of oncology to establish content validity. Reliability testing was conducted on a random sample of 182 women.  Internal consistency reliability for the posttested General Knowledge subscale was .60, and for the Curability subscale was .62.  The overall alpha coefficient was .71.  In combination with the BCKT, these subscales can be used by researchers studying the relationship between knowledge and screening practices.
Additional file 9 of 17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson’s disease are associated with LRRC37A/2 expression in astrocytes
Creators: name: Bowles, Kathryn R.
name: Pugh, Derian A.
name: Liu, Yiyuan
name: Patel, Tulsi
name: Renton, Alan E.
name: Bandres-Ciga, Sara
name: Gan-Or, Ziv
name: Heutink, Peter
name: Siitonen, Ari
name: Bertelsen, Sarah
name: Cherry, Jonathan D.
name: Karch, Celeste M.
name: Frucht, Steven J.
name: Kopell, Brian H.
name: Peter, Inga
name: Park, Y. J.
name: Charney, Alexander
name: Raj, Towfique
name: Crary, John F.
name: Goate, A. M.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 9. Supplementary table 2
Additional file 1 of Association between indicators of systemic inflammation biomarkers during puberty with breast density and onset of menarche
Creators: name: Michels, Karin B.
name: Keller, Kristen
name: Pereira, Ana
name: Kim, Claire E.
name: Santos, José L.
name: Shepherd, John
name: Corvalan, Camila
name: Binder, Alexandra M.
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Plant Biology

description: Additional file 1. Study population characteristics of girls with measured inflammatory markers at Tanner stage 2 but no breast composition measurements at Tanner stage 4.
Brief an [Johann] I Bernoulli
Creators: name: Funck, Johann Kaspar
Publisher: name: [s.n.]
Year: 1707
Subjects: Boulliau, Ismael1605-1694
Hamberger, Georg Albrecht1662-1716
Hoffmann, Johann Heinrich1669-1716
Junius, Ulrich1670-1726
Kepler, Johannes1571-1631
Rivinus, Augustus Quirinus1652-1723
Wing, Vincent1619-1668
Wurzelbau, Johann Philipp von1651-1725

description: Funck übersendet zwei Traktate von Junius und teilt Beobachtungen über eine Mondfinsternis aus Leipzig, Jena und Nürnberg mit. Ein nach Kepler, Bulliald und Wing berechneter Merkurdurchgang konnte nicht beobachtet werden.
description: von Joh[ann] Caspar Funck
description: Siegel mit Schnurstück
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Datenimport aus LIDOS / Bernoulli (2004-07-02)
Additional file 1 of Analyzing patient experiences using natural language processing: development and validation of the artificial intelligence patient reported experience measure (AI-PREM)
Creators: name: van Buchem, Marieke M.
name: Neve, Olaf M.
name: Kant, Ilse M. J.
name: Steyerberg, Ewout W.
name: Boosman, Hileen
name: Hensen, Erik F.
Publisher: name: figshare
Year: 2022
Subjects: subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences

description: Additional file 1. Complete overview of the different topics percategory. This additional file presents the full output of the topic modeling step from the NLP pipeline. It shows a complete overview of the different topics that were extracted per category.
Discovery of novel effectors of the proteasome pathway: cyclopentenones as inhibitors of ubiquitin isopeptidase activity
Creators: name: Mullally, James Edward
Publisher: name: University of Utah
Year: 2012
Subjects: Neoplasms
Drug Therapy

description: I discovered that certain electrophilic prostaglandins inhibit the ubiquitin-specific protease (USP) activity of the proteasome pathway. Herein, evidence is presented that supports the hypothesis that the cross-conjugated α,β-unsaturated dienone is a molecular determinant for the potency of this activity, and that this chemical feature causes an alteration in cellular ubiquitin dynamics, resulting in decreased free ubiquitin and decreased protein degradation. I show that this decrease in protein degradation activates the unfolded-protein response (UPR) of both the cytoplasm and the endoplasmic reticulum, likely due to the accumulation of deranged/misfolded proteins. I make the novel observation that as an attempt to compensate for the loss in protein degradation by the proteasome pathway, the lysosomal degradation pathway is activated in USP inhibitor treated cells. Lastly I show that, ultimately, cell death occurs due to the build-up of toxic levels of cellular protein. These data reconcile previously known effects of prostaglandin treatment, namely that heat-shock proteins are up-regulated and that a number of short-lived proteins are stabilized, and in so doing, establish a cohesive model for prostaglandin-induced apoptosis. The potential that components of the ubiquitin-proteasome pathway may be useful targets for cancer chemotherapy has been realized only recently with the success, in human clinical trials, of the proteasome inhibitor, VELCADE™ (PS-341). Given that several hundred other potential molecular targets reside within the proteasome pathway, there is intense interest in discovering novel points for drug intervention. Our data suggest that inhibition of USP activity represents a legitimate target for chemotherapeutic development.
Phenolic profile by HPLC-ESI-MS/MS and enzymatic inhibitory effect of Bryophyllum delagoense
Creators: name: Katrucha, Edenize Maria
name: Lopes, Jéssica
name: Paim, Milena
name: Santos, Júlia Candiani dos
name: Siebert, Diogo Alexandre
name: Micke, Gustavo Amadeu
name: Vitali, Luciano
name: Alberton, Michele Debiasi
name: Tenfen, Adrielli
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine

description: Bryophyllum delagoense (Eckl. & Zeyh.) Druce, native to Madagascar, is popularly known as “abyssian cactus” and popularly used in folk medicine as an analgesic and healing agent. The study methodology was divided into the phytochemical study: fractionation and identification of phenolic compounds by HLPC-ESI-MS/MS from the methanolic extract (ME), and fractions (DCMF and EAF) of leaves of B. delagoense, and biological activity with acetylcholinesterase and α-glucosidase inhibition of extracts and fractions by in vitro enzymatic techniques. Twenty-seven phenolic compounds were identified, being the highest concentration of syringic acid (87.848 mg g−1). The DCMF fraction showed the best biological activity for inhibition of α-glucosidase enzyme (0.125 mg mL−1).
Qualitative analysis of the existence of a real estate bubble in China
Creators: name: Nguyen, Trang Thi My
Publisher: name: University of Utah
Year: 2012

description: As the US economy continues to recover from an immense collapse in its housing market, there is speculation of a comparable situation arising in China with real estate prices continuing to skyrocket and creating concerns of a bubble. This paper aims to define what a "bubble" is and whether or not a housing bubble exists in China. As the US economy and China's economy are closely tied, this topic is relevant for determining the backlash effect on the US should China's real estate market collapse. The existence of a real estate bubble in China has been highly publicized with considerable disagreement regarding whether China's current state of rising housing prices is representative of a bubble. This paper will focus on the definition and identification of a bubble and use related research findings to better analyze both sides of this argument in detecting the presence of a potential housing bubble in China. By analyzing historical accounts of bubbles through comparisons of other economies that have experienced or are experiencing growth situations similar to China, I identified the 5 factors most indicative of a bubble: rapid economic growth, investment and construction growth, the accessibility of credit, income disparity, and the role of population. I then compare the situation in China along these five dimensions. Overall, my comparisons suggest that the rapid real estate price increases in China are more indicative of supply and demand and are not reflective of a bubble.
Local anaesthetic potential, metabolic profiling, molecular docking and in silico ADME studies of Ocimum forskolei, family Lamiaceae
Creators: name: Zahran, Eman Maher
name: Abdelmohsen, Usama Ramadan
name: Shalash, Mahmoud. M.
name: Salem, M. Alaraby
name: Khalil, Hany Ezzat
name: Desoukey, Samar Yehia
name: Fouad, Mostafa Ahmed
name: Krischke, Markus
name: Mueller, Martin
name: Kamel, Mohamed Salah
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified

description: The present study aimed to detect the bioactive metabolites from Ocimum forskolei aerial parts which are responsible for the local anaesthetic activity of the ethyl acetate fraction. Following a bioassay-guided fractionation, twelve compounds were dereplicated from the ethyl acetate fraction which was the most potent one with a mean onset of action (1.43 ± 0.07****) min compared to tetracaine as a positive control (1.37 ± 0.07****) min. These compounds, along with seven other compounds (isolated by diverse chromatographic techniques) were subjected to a molecular docking study to declare the top scoring compounds predicted to be responsible for such activity. The results highlighted Rabdosiin and Apigenin-7-O-rutinoside as the main bioactive leaders of the local anaesthesia via forming multiple H- bonding with the sodium ion channels leading to their blockade and loss of pain sensation, which strongly supports the use of O. forskolei as a local anaesthetic agent.
Additional file 2 of Association between indicators of systemic inflammation biomarkers during puberty with breast density and onset of menarche
Creators: name: Michels, Karin B.
name: Keller, Kristen
name: Pereira, Ana
name: Kim, Claire E.
name: Santos, José L.
name: Shepherd, John
name: Corvalan, Camila
name: Binder, Alexandra M.
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Plant Biology

description: Additional file 2. Study population characteristics of girls with measured inflammatory markers at Tanner stage 4 but no breast composition measurements at Tanner stage 4.
Brief an [Daniel I Bernoulli]
Creators: name: Fuss, Nikolaj I.
Publisher: name: [s.n.]
Year: 1777
Subjects: Bergius, Peter Jonas1730-1790
Bernoulli, Johann1744-1807
Born, Ignaz von1742-1791
Buffon, Georges Louis Le Clerc de1707-1788
Burman, Pieter1713-1778
Condorcet, Jean Antoine Nicolas de Caritat de1743-1794
Daubenton, Louis Jean Marie1716-1799
Domaṧnev, Sergej Gerasimovič1743-1795
Bulgarēs, Eugenios1716-1806
Euler, Johann Albrecht1734-1800
Euler, Leonhard1707-1783
FriedrichII. Preußen, König1712-1786
Gleditsch, Johann Gottlieb1714-1786
GnovilErzbischof von Nowgorod und Petersburg
Güldenstädt, Johann Anton1745-1781
Haller, Albrecht von1708-1777
KatharinaII. Russland, Zarin1729-1796
Kulibin, Ivan P1735-1818
Lagrange, Joseph Louis de1736-1813
Lorgna, Antonio Mario1730-1796
Mallet, Jacques-André1740-1790
Marggraf, Andreas Sigismund1709-1782
Maskelyne, Nevil1732-1811
Melanderhielm, Daniel1726-1810
Messier, Charles1730-1817
Orlov, Vladimir Grigorʹevič1743-1831
Panin, Nikita IvanovičGraf1718-1783
PaulI Kaiser von Russland1754-1801
Potemkin, Grigorij Aleksandrovič1739-1791
Pringle, John1707-1782
RhebinderStallmeister Katharinas II
Rogerson, John1741-1823
Roumanzow-Sadunaisky, Petr Aleksandrowitsch1725-1796
Rumovski, Stephan1734-1815
Scherbatow, MichailFürst1733-1790
Schmidt, Jacob Friedrich1732-1786
Šuvalov, Ivan I1727-1798
Sigaud de la Fond, Jean René1740-1810
Stroganov, Aleksandr S1733-1811
Černyšëv, Ivan Grigor'evič1726-1797
Toaldo, Giuseppe1719-1797
Treskot, Johann1719-1786
Wallerius, Johan Gottschalk1709-1785
Wjasemski, Alexander Alexejewitsch1727-1793

description: von Niklaus Fuss
description: Am Briefkopf "F.V."
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Datenimport aus LIDOS / Bernoulli (2004-07-02)
Coming of age in the box: social function and Japanese karaoke
Creators: name: Perry, Donovan Reuel
Publisher: name: University of Utah
Year: 2013
Subjects: Age
Function
Japan
Japanese
Karaoke
Social

description: Karaoke in Japan is all too often overlooked as simply being a leisure activity. Even the scholarly work that has looked at karaoke in various terms has usually been limited to topics such as communication, social class and individualism versus collectivism. A structural-functionalist approach is utilized in analyzing the karaoke box in terms of the social function that the box provides, and is complemented by the use of the theories of socialization and dramaturgy. Though the karaoke box is emphasized, different karaoke spaces are also examined in terms of the age and sex of frequenters. The result is that the karaoke box aids in the transition from youth to adulthood in various ways, which is a large part of the social function that the karaoke box provides in Japanese society. This and other social functions of the karaoke box is demonstrated through academic research, participant observation and casual interviews.
Brief an Daniel I Bernoulli
Creators: name: Fontana, Gregorio
Publisher: name: [s.n.]
Year: 1771

description: von Greg[orio] Fontana
description: Am Briefkopf Marginalie "F. V. 1 Nov. 1771"
description: Mit rotem Siegel
description: Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Datenimport aus LIDOS / Bernoulli (2004-07-02)
Engineering Systematically Bioavailable Analogs of Endogenous Neuropeptides
Creators: name: Green, Brad Reed
Publisher: name: University of Utah
Year: 2014

description: A significant amount of effort has been put into the research and development of peptide-based drugs for the treatment of human disease. The use of anticonvulsant neuropeptides for the treatment of pain and epilepsy has recently shown promise. Neuropeptides such as galanin (Gal), neuropeptide Y (NPY), neurotensin (NT), and neuropeptide W (NPW) modulate their biological activities through their respective receptor targets in the brain. Introduced intracerebroventricularly, these compounds have been shown to reduce pain and seizure activity. Upon systemic administration, however, these compounds do not exhibit the same potency. The metabolic instability and inability to penetrate the blood-brain barrier (BBB) has precluded their widespread use as drugs for neurological disorders. This work will describe the application of the lipidizationcationization strategy to several endogenous neuropeptides towards increasing their metabolic stability and improving systemic bioavailability. Based on existing structure activity relationship (SAR) information, analogs of Gal, NPY NT, and NPW were designed and chemically synthesized. The combination of increased cationic character (oligo-Lys motifs) and increased lipophilicity (lipoamino acid) resulted in analogs with increased octanol-water partitioning coefficients (logD), significantly improved metabolic stabilities, while retaining high affinities for their native receptors. Furthermore, these analogs were shown to modulate seizure activity in animal models of epilepsy upon systemic administration. Our results suggest that the cationizationlipidization strategy may be broadly applicable across a wide variety of neuropeptides, opening up a large repertoire of new drug candidates for the treatment of neurological disorders.
The ambiguous role of the nurse educator: baccalaureate faculty workload and its impact on research activities.
Creators: name: Anderson, Mary Ann Romer
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Nursing
subject: FOS: Health sciences
subject: Health Education
subject: Higher Education

description: The purpose of this study was to determine the impact of baccalaureate faculty workload on the opportunity and ability of Nursing; faculty to undertake scholarly research.  Inherent in this study were the perceptions of baccalaureate Nursing; faculty concerning the concepts of role conflict and role ambiguity and their effects on the pursuit and production of professional research.  The study was conducted by mailing an 18 item questionnaire to 116 baccalaureate faculty members in three colleges of Nursing; situation in state university medical centers in the Rocky Mountain Region of the United States.  There was a 58% return rate from the questionnaires.  The data were analyzed statistically using chi-square, Kruskal-Wallis Anova, Wilcoxon matched-pairs signed-ranked, and Mann-Whitney U tests as well as frequencies to determine what impact the workload might have on the production of Nursing; research.  The results of the study indicate three important findings.  First, and most significant, is that the faculty surveyed reported that they generally do not fulfill well the three requirements of teaching, research, and community service traditionally expected in the university setting.  Second, role conflict and role ambiguity were validated statistically as contributors to the low level of research produced. The third prominent finding was that the faculty members in this study met the description of typical baccalaureate faculty members referred to in the literature.
Additional file 1 of Impact of Infectious Diseases training in the perception of antibiotic resistance and rational use of antibiotics among Spanish medical students – a cross-sectional study
Creators: name: Yuste, José Ramón
name: Matteo, Andrés Blanco-Di
name: Gruber, Fernando
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1.
Additional file 4 of Association between indicators of systemic inflammation biomarkers during puberty with breast density and onset of menarche
Creators: name: Michels, Karin B.
name: Keller, Kristen
name: Pereira, Ana
name: Kim, Claire E.
name: Santos, José L.
name: Shepherd, John
name: Corvalan, Camila
name: Binder, Alexandra M.
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Plant Biology

description: Additional file 4. Association of quartiles of inflammatory markers measured at Tanner 2 and Tanner 4 with breast composition measured at Tanner 4; restricting to individuals for which inflammatory markers were measured at Tanner 2 and Tanner 4.
Brief an [Daniel I Bernoulli]
Creators: name: Fuss, Nikolaj I.
Publisher: name: [s.n.]
Year: 1777
Subjects: Bernoulli, Johann1744-1807
Deparcieux, Antoine1703-1768
Domaṧnev, Sergej Gerasimovič1743-1795
Dupré de Saint-Maur, Nicolas-François1695-1774
Euler, Johann Albrecht1734-1800
Euler, Leonhard1707-1783
GustavIII. Schweden, König1746-1792
Halley, Edmond1656-1742
Hodgson, James1672-1755
KatharinaII. Russland, Zarin1729-1796
Kersseboom, Willem1691-1771
Kulibin, Ivan P1735-1818
Lambert, Johann Heinrich1728-1777
MarijaZarin von Russland1759-1828
Pallas, Peter Simon1741-1811
SchwarzenbachAppenzeller, Erbauer einer Brücke in Irland
Simpson, Thomas1710-1761
SmartVerfasser von Sterblichkeitstabellen
Stanisław AugustII. Polen, König1732-1798
Struick
Süssmilch, Johann Peter1707-1767
Wargentin, Pehr1717-1783

description: von Niklaus Fuss
description: Am Briefkopf "F.V." und "14/25 Juill. 1777"
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Datenimport aus LIDOS / Bernoulli (2004-07-02)
Uncertainty quantification for holographic interferographic images
Creators: name: Centauri, Laurie Ann
Publisher: name: University of Utah
Year: 2012
Subjects: Holographic interferometry
Plumes
Uncertainty quantification

description: Current comparison methods for experimental and simulated holographic interferometric images are qualitative in nature. Previous comparisons of holographic  interferometric images with computational fluid dynamics (CFD) simulations for validation have been performed qualitatively through visual comparison by a data  analyst. By validating the experiments and CFD simulations in a quantifiable manner using a consistency analysis, the validation becomes a repeatable process that gives a consistency measure and a range of inputs over which the experiments and CFD simulations give consistent results. The quantification of uncertainty in four holographic interferometric experiments was performed for use in a data collaboration with CFD simulations for the purpose of validation. The model uncertainty from image-rocessing, the measurement uncertainty from experimental data variation, and the scenario uncertainty from the bias and parameter uncertainty was quantified. The scenario uncertainty was determined through comparison with an analytical solution at the helium inlet (height, x = 0), including the uncertainty in the experimental parameters from historical weather data. The model uncertainty was calculated through a Box-Behnkin sensitivity analysis on three imageprocessing code parameters. Measurement uncertainty was determined through a statistical analysis to determine the time-average and standard deviation in the interference fringe positions. An experimental design matrix of CFD simulations was iv performed by Weston Eldredge using a Box-Behnkin design with helium velocity, temperature, and air co-flow velocity as parameters in conjunction to provide simulated  measurements for the data collaboration Data set.  Over 3,200 holographic interferometric images were processed through the course of this study. When each permutation of these images is taken into account through all the image-processing steps, the total number of images processed is over 13,000. Probability distribution functions were plotted for each interference fringe order at each measurement height, making a total of 22 PDFs. Model, scenario, and measurement uncertainty was quantified in the experiments. The CFD simulations were performed. The final uncertainty attributed to the experiments resulted in a maximum uncertainty of -7.96 fringes. The largest contributor to uncertainty was the scenario uncertainty with  measurement uncertainty as the second largest. The model uncertainty was very small and as such had the smallest contribution to the overall experimental uncertainty. In the future, the results of this study will be used in conjunction with the CFD simulations discussed and their attributed error in a data collaboration to determine Data set consistency for validation.
Antiviral activity of amides and carboxamides of quinolizidine alkaloid (−)-cytisine against human influenza virus A (H1N1) and parainfluenza virus type 3
Creators: name: Fedorova, Victoria A.
name: Kadyrova, Renata A.
name: Slita, Alexander V.
name: Muryleva, Anna A.
name: Petrova, Polina R.
name: Kovalskaya, Alena V.
name: Lobov, Alexander N.
name: Zileeva, Zulfiya R.
name: Tsypyshev, Dmiry O.
name: Borisevich, Sophia S.
name: Tsypysheva, Inna P.
name: Vakhitova, Julia V.
name: Zarubaev, Vladimir V.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: Novel derivatives of quinolizidine alkaloid (−)-cytisine were synthesised. ADME properties, cytotoxicity against HEK293 cells and activity against viruses of influenza A/California/07/09(H1N1)pdm09 virus (IAV) and human parainfluenza virus type 3 (HPIV3) were evaluated. It was shown, that 9-carboxamides of methylcytisine (with phenyl and allyl urea’s fragments) are most active compounds against IAV probably due to predicted in silico peculiarity of their interactions with the 4R7B active site of IAV neuraminidase. Indexes of selectivity (SI) calculated as ratio of CC50/IC50 of these ureas are 47 and 59 correspondingly. It was also found, that derivatives obtained from allyl isocyanate and (−)-cytisine or 9,11-dibromocytisine are able to inhibit a reproduction of HPIV3 with SI = 58 and 95. Moreover, last compound - (1 R,5R)-N-allyl-9,11-dibromo-8-oxo-1,5,6,8-tetrahydro-2H-1,5-methanopyrido[1,2-a][1,5]diazocine-3(4H)-carboxamide with two bromine atom in 2-pyridone core of starting (−)-cytisine molecule, demonstrated high activity against HPIV3 (SI = 95) and moderate activity against IAV (SI = 16).
Additional file 1 of The impact of coalition characteristics on outcomes in community-based initiatives targeting the social determinants of health: a systematic review
Creators: name: Nagorcka-Smith, Phoebe
name: Bolton, Kristy A.
name: Dam, Jennifer
name: Nichols, Melanie
name: Alston, Laura
name: Johnstone, Michael
name: Allender, Steven
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 1. Search strings. A full list of search terms used to conduct the systematic review.
Bank-moliya sohasidagi korrupsiyaga qarshi kurashda jamoatchilik nazoratining o'rni va ahamiyati
Creators: name: Doniyorхоdjayeva Nilufar Doniyorхоdjayevna
Publisher: name: Zenodo
Year: 2024

description: Annotatsiya. Ushbu maqolada muallif bank-moliya sohasidagi korrupsiyaga qarshi kurash, sohadagi muammolar, shuningdek, ularning yechimi bo’yicha fikr yuritadi. Bu masalada jamoatchilik nazoratining o’rni, ahamiyati ham bu borada mamlakatimizda amalga oshirilayotgan chora-tadbirlar bo’yicha tahlilni amalga oshiradi.

Kalit so’zlar: bank-moliya sohasi, korrupsiya, jamoatchilik nazorati, davlat xaridlari, ochiqlik, shaffoflik, xalqaro tashkilotlar tavsiyalari
Synthesis of titanium dioxide nanotubes from thin film on silicon wafer for photoelectrochemical cell
Creators: name: Nanaiah, Karumbaiah Chappanda
Publisher: name: University of Utah
Year: 2014
Subjects: Splitting water
Thin films
Titanium dioxide nanotubes

description: TiO2 is an extensively studied material due to its nontoxic, environmental friendly, corrosion-resistant nature and wide band gap (~3 eV). TiO2 nanotubes (T-NTs) synthesized via electrochemical anodization have been studied extensively, with particular focus on their electrical and optical properties. The advantage of T-NT is the large surface area to volume ratio. T-NT has been used to demonstrate many applications such as sensors and energy harvesting. These applications have traditionally been demonstrated via T-NT synthesized on Ti foil. However, there is currently no commercially available T-NT- based device, which may be due to a lack of fabrication techniques, to make such devices on a large scale. One of the requirements for fabricating compact T-NT- based devices is the need for a stable and planar substrate. The titanium foils commonly used for T-NT synthesis are mechanically flexible, making them more prone to bending, limiting the integration of T-NT with microfabrication techniques. Here, we present the synthesis of T-NT on Si wafer at room temperature from direct current (D.C.) sputtered as well as e-beam evaporated thin Ti film. Hundred nm SiO2 was used to electrically isolate the T-NT from the substrate. We demonstrate integration of the synthesis of T-NT with photolithography, which is one of the most important requirements for scaling up a T-NT-based device. The T-NT was stable up to 500oC, which is required for improved charge transport. The T-NT was 1.4 times longer than the thickness of the Ti film, showing selective electric field-assisted etching of Ti by the electrolyte. We also report site-specific and patterned growth of the T-NT. The effect of properties of thin films such as grain size, residual stress and density on the morphology of T-NT was studied to improve the stability and quality of the T-NT. We demonstrate the synthesis of TiO2-WO3 composite nanotubes for photoelectrochemical cells with up to a 40% increase in photocurrent in comparison to plain T-NT. The T-NT was extensively studied and characterized using SEM, AFM, UV-Vis spectroscopy, XRD, and XPS.
Additional file 3 of Association between indicators of systemic inflammation biomarkers during puberty with breast density and onset of menarche
Creators: name: Michels, Karin B.
name: Keller, Kristen
name: Pereira, Ana
name: Kim, Claire E.
name: Santos, José L.
name: Shepherd, John
name: Corvalan, Camila
name: Binder, Alexandra M.
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Plant Biology

description: Additional file 3. Association of inflammatory markers measured at Tanner 2 and Tanner 4 with breast composition measured at Tanner 4; restricting to individuals for which inflammatory markers were measured at Tanner 2 and Tanner 4.
Additional file 2 of The impact of coalition characteristics on outcomes in community-based initiatives targeting the social determinants of health: a systematic review
Creators: name: Nagorcka-Smith, Phoebe
name: Bolton, Kristy A.
name: Dam, Jennifer
name: Nichols, Melanie
name: Alston, Laura
name: Johnstone, Michael
name: Allender, Steven
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 2. Data extraction table. A copy of the table used to extract data from studies included in the systematic review.
Brief an Daniel I Bernoulli
Creators: name: Fontana, Gregorio
Publisher: name: [s.n.]
Year: 1771
Subjects: Bernoulli, Daniel1751-1834
Bernoulli, Johann1710-1790
Briggs, Henry1561-1630
Euler, Leonhard1707-1783
Hell, Maximilian1720-1792
Lalande, Joseph Jérôme Le Français de1732-1807
Scarella, Giovan Battista1711-1779

description: von Greg[orio] Fontana
description: Siegel. Schluss des Textes und P.S. in französischer Sprache.
description: Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Datenimport aus LIDOS / Bernoulli (2004-07-02)
description: Bl. 32-34: Scarella, Hydrodynamik, pp.155-160, "Appendice" ("MDCCLXXI. die XV. Augusti.")
Pathologic and genetic characterization of two familial congenital heart defects
Creators: name: Bleyl, Steven Benjamin
Publisher: name: University of Utah
Year: 2012
Subjects: Total Anomalous Pulmonary Venous Return

description: Total anomalous pulmonary venous return (TAPVR) is a congenital heart defect in which the pulmonary veins fail to connect to the left atrium returning instead to the right atrium or one of its venous tributaries. Using linkage analysis in a large family with autosomal dominant transmission of TAPVR, we mapped a TAPVR locus on chromosome 4pl3-q12. Linkage analysis in additional families and analysis of two overlapping founder-effect haplotypes limit the TAPVR-1 interval to proximal and distal intervals, each of about 1 cM. Further study of TAPVR has focused on physical mapping of the region, Fluorescence in situ hybridization (FISH) to search for chromosomal abnormalities, and screening of candidate genes. As part of the search for candidate genes in the distal TAPVR-1 interval, I cloned and characterized a novel bicoid-related homeodomain-encoding gene named Sakasama (SAMA-1). Expression of SAMA-1 is tissue specific and developmentally regulated, with highest expression in the brain and lungs. Use of alternative transcription initiation sites, which may encode long and short forms of the protein, is also tissue specific and developmentally regulated. No mutations in this gene were discovered in any TAPVR patients. I have expressed this gene in Xenopus to test the hypothesis that it functions as an inhibitor of other bicoid-related homeodomain genes. Other work toward my thesis focused on an X-linked recessive, neonatal lethal cardiomyopathy. called isolated noncompaction of the ventricular myocardium (INVM). We mapped this disorder to Xq28 using linkage analysis in a family with six affected males, four of whom died in the first year. The gene mapped near the Barth syndrome locus, which shares some phenotypic overlap, including cardiomyopathy. A glycine-to-arginine mutation was discovered in a conserved domain of the same protein defective in Barth syndrome, called Tafazzin. The INVM phenotype is more severe than most cases of the allelic Barth syndrome, which may be explained by the genotypes seen in each disorder. Efforts to elucidate the cellular function of Tafazzin by disruption of the yeast homologue, YPR140W have been initiated. Recent reports suggest the protein may function as an acyltransferase.
Styrylpyrone, isolated from an Amazon plant, induces cell cycle arrest and autophagy in Leishmania amazonensis
Creators: name: de Souza Fernandes, Nilma
name: Desoti, Vânia Cristina
name: Dias, Alcilene
name: da Silva, Yasmin Cunha
name: de Azevedo dos Santos, Ana Paula
name: Passarini, Guilherme Matos
name: Nakamura, Celso Vataru
name: da Veiga Junior, Valdir Florêncio
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Computational Biology

description: The search for bioactive compounds against diseases is imperative and the richness of the Amazon provides a large source to be explored. Current therapies for the treatment of parasitic infections have severe side effects and low efficacy, which makes the development of an effective chemotherapy extremely important. In this study, we describe the isolation of styrylpyrone 4-methoxy-6-(11,12-methylenedioxy-trans-styryl)-2-pyrone (SP), from the Amazonian tree species, Aniba panurensis, the in vitro activity against Leishmania amazonensis promastigotes, and its in silico pharmacokinetics properties. The results showed morphological and ultrastructural alterations, cell cycle impairment, increased reactive oxygen species production, accumulation of lipid bodies and formation of autophagic vacuoles in SP-treated parasites. In silico studies revealed that the compound has a high drug-score, which is encouraging for further investigation. Our results indicate that SP is a promising drug candidate, which induces alterations in L. amazonensis leading to parasite death through cell cycle arrest and autophagy.
Workers with chronic pain: recovery and reintegration
Creators: name: Augello, Jean Bass
Publisher: name: University of Utah
Year: 2012

description: The purpose of this phenomenological study was to explore the lived experiences of workers who were disabled from work for a minimum of 6 months by chronic musculoskeletal pain and then eventually returned to full-time employment. Through open-ended, semistructured interviews, a heterogeneous group of 9 employed workers articulated rich and varied descriptions of their unique experiences. A qualitative data analysis revealed the emergence of themes and subthemes that created a picture of a common experience involving perceived obstacles in dealing with the healthcare system, a tendency to seek alternative and complementary medical treatments, a need to involve themselves in their recoveries, widespread impacts on their personal lives, and multiple issues in reintegrating to the workplace. The results of the study indicate a need for more research that focuses not only on the disabled worker but also on the role of the healthcare system in facilitating recovery and reintegration to the workplace.
Brief an Daniel I Bernoulli
Creators: name: Fontana, Gregorio
Publisher: name: [s.n.]
Year: 1771
Subjects: Alembert, Jean Le Rond d'1717-1783
Bernoulli, Johann1667-1748
Bernoulli, Johann1710-1790
Bernoulli, Johann1744-1807
Euler, Leonhard1707-1783
Fontana, Felice1730-1805

description: von Greg[orio] Fontana
description: Siegelspuren. Am Briefkopf Marginalie "1 Sept. 1771 F.V."
description: Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Datenimport aus LIDOS / Bernoulli (2004-07-02)
The chemistry and biological activities of Citrus clementina Hort. Ex Tanaka (Rutaceae), a vegetatively propagated species
Creators: name: Bissim, Samuel Magloire
name: Kenmogne, Sidonie Beatrice
name: Lobe, Jules Songue
name: Atangana, Albert Fouda
name: Bissoue, Achile Nouga
name: Langat, Moses K.
name: Isyaka, Sani M.
name: Lateef, Mehreen
name: Emmanuel, Ngeufa Happi
name: Wansi, Jean Duplex
name: Ali, Muhammad Shaiq
name: Waffo, Alain François Kamdem
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Plant Biology

description: We report the chemistry and biological activities of a Cameroonian Citrus clementina Hort. Ex Tanaka, a vegetatively propagated species. The compounds isolated from this plant were determined to be the known 5-hydroxy-6,7,8,3’,4’-pentamethoxyflavone (1), tangerine (3), nobilletin (4), 5,7,8,4’-tetramethoxyflavone (5), citracridone I (6), 5-hydroxynoracronycine (7), citracridone III (8), xanthyletin (10), suberosin (9), E-suberenol (11), E-methoxysuberenol (13), 6-formylumbelliferone (12), aurantiamide acetate (2), limonin (14), stigmasterol, β-sitosterol and β-sitosterol-3-O-β-D-glucoside. The structures of the compounds were established on the basis of their NMR spectroscopic data and comparison with published data. Methanol leaf extract and compounds 1, 2, 4, 6, 7 and 10 were evaluated for their anti-inflammatory, antioxidant, urease and anti-diabetic effects. Compound 10 showed antioxidant activity, anti-inflammatory effect, urease activity and anti-diabetic activity with IC50 values of 47.3 µM, 33.5 µM, 25.2 µM and 33.9 µM respectively, values that were comparable to the respective positive standards.