cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 07.12.1968, erstellt am Sonnenobservatorium Kanzelhöhe, Kärnten
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage im Sonnenobservatorium Kanzelhöhe in Sattendorf, Österreich. Instrument: Heliostat mit Refraktor Eigenbau (Öffnung 110mm, f = 1650mm, projiziertes Sonnenbild D = 25cm)
Describing the experience of mammography
Creators: name: Smith-Kent, Irene E.
Publisher: name: University of Utah
Year: 2012
Subjects: Experiences
Demographic

description: Screening mammography is an important tool in the early detection of breast cancer. Cancer can be detected earlier through the use of mammography, resulting in decreased breast cancer mortality. However, several deterrents to mammography have been identified, including attitudinal barriers. The purpose of this descriptive, correlational study was to describe various factors such as trait affect and personal characteristics expected to be associated with a woman's experience of pain or discomfort during screening mammography. In addition, sensations experienced during the mammogram were described. Using a Preprocedure Questionnaire and a Postprocedure Questionnaire, developed for this study, as well as a measure of trait affect (Positive and Negative Affect Schedule (PANAS)), the women (N = 99) rated several variables believed to influence the experience of pain or discomfort during mammography. Data were analyzed using descriptive statistics and Pearson correlation coefficients. Mammography pain was not related to a previous mammogram, family history, weight, cup size, menstrual history, hormone replacement, caffeine ingestion, waiting time, technician, time of day, machine, number of pregnancies, breastfeeding history, breast pain prior to mammography, or trait negative/positive affectivity. However, as expected, pain and the rating of mammography as being uncomfortable were highly positively related, as were mammogram pain and the likelihood that pain would prevent women from seeking another mammogram. The sensations most frequently reported during screening mammography included pressure, pulling, stretching, pinching, and crushing
Bereavement and the elderly: anticipatory grief
Creators: name: Colbert-O'Donnell, Jeanie
Publisher: name: University of Utah
Year: 2012
Subjects: Longitudinal Studies
Attitude to Death
Bereavement
Death
Grief

description: The purpose of this study was to determine if the anticipation of the spouse's death would assist in the bereavement process and adaptation to the loss. Those who anticipated the loss were compared to those who did not with regards to the adaptation to the loss at three time periods, 3 weeks and 1 and 2 years after the death of the spouse. The only statistically significant finding was that the spouses who anticipated the death reported less shock at the loss initially and a higher degree of shock at 2 years, reporting more of it than those who did not anticipate the death. Other findings demonstrate a general trend toward gradual improvement over time. Nursing implications of this study were addressed in three areas: research, practice and education.
[3 Ansichten von Eleusis]
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1870

description: [Eleusis]
description: Es handelt sich bei den Fotografien um Albuminabzüge
description: Unbekannte/r Fotograf/in
description: Digitalisierung=Digitization=Numérisation Oktober 2024 TIFF
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 14.09.1968, erstellt vermutlich von Sebestova am Skalnate Pleso Observatorium
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage am Skalnate Pleso Observatorium. Es sind zudem statistische Angaben für die Bestimmung der Fleckenrelativzahl notiert. Instrument: unbekannt, Sonnenbild D = 25 cm
Differential benefits to firms participating in multipartner collaborative innovation
Creators: name: Brown, Kory Dee
Publisher: name: University of Utah
Year: 2012
Subjects: Alliances
Bluetooth
Collaboration
Innovation
Networks

description: Great innovations seldom come from a single individual or firm. Rather, entire networks of people, usually sponsored by many firms drive great innovation, innovation that is rarely captured in a single product or service, but an entire platform sponsored by an ecosystem of firms. Many of these innovative platforms are guided by a visible hand, coalitions of firms that coordinate and collaborate. One such "visible hand" is the multipartner alliance, a collection of tens, hundreds, or even thousands of firms assembled to collaboratively define, develop, and promote innovation. While much research in collaborative innovation assumes homogenously available benefits and an exogenously determined appropriation of these benefits, this dissertation assumes heterogeneity and explores the degree to which benefits may be endogenously determined. The benefit of interest is a firm's own innovation productivity based on technologies defined by the multipartner alliance. In studying firm actions, choices, and characteristics as they relate to participating in multipartner alliances, I examine the relationships between a firm's innovation productivity and its entry timing, value-chain position, level of membership, contribution, timing of contribution, and size. These are tested primarily using hierarchical negative binomial regression and an original dataset developed in cooperation with the Bluetooth Special Interest Group, a multipartner alliance of over 12,000 firms interested in defining, developing, and promoting short range wireless technology. Empirical findings suggest support of heterogeneity in the availability of benefits and a degree of endogeneity in how they are appropriated.
New insights in the metabolism of oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone
Creators: name: Aprile, Silvio
name: Canavesi, Rossana
name: Matucci, Rosanna
name: Bellucci, Cristina
name: Grosso, Erika Del
name: Grosa, Giorgio
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Marine Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: 1. Oxybutynin hydrochloride is an antimuscarinic agent prescribed to patients with an overactive bladder (OAB) and symptoms of urinary urge incontinence. Oxybutynin undergoes pre-systemic metabolism, and the N-desethyloxybutynin (Oxy-DE), is reported to have similar anticholinergic effects. 2. We revisited the oxidative metabolic fate of oxybutynin by liquid chromatography–tandem mass spectrometry analysis of incubations with rat and human liver fractions, and by measuring plasma and urine samples collected after oral administration of oxybutynin in rats. This investigation highlighted that not only N-deethylation but also N-oxidation participates in the clearance of oxybutynin after oral administration. 3. A new metabolic scheme for oxybutynin was delineated, identifying three distinct oxidative metabolic pathways: N-deethylation (Oxy-DE) followed by the oxidation of the secondary amine function to form the hydroxylamine (Oxy-HA), N-oxidation (Oxy-NO) followed by rearrangement of the tertiary propargylamine N-oxide moiety (Oxy-EK), and hydroxylation on the cyclohexyl ring. 4. The functional activity of Oxy-EK was investigated on the muscarinic receptors (M1-3) demonstrating its lack of antimuscarinic activity. 5. Despite the presence of the α,β-unsaturated function, Oxy-EK does not react with glutathione indicating that in the clearance of oxybutynin no reactive and potentially toxic metabolites were formed.
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 08.12.1968, erstellt von M. Rackova-Sebestova am Skalnate Pleso Observatorium
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage am Skalnate Pleso Observatorium. Es sind zudem statistische Angaben für die Bestimmung der Fleckenrelativzahl notiert. Instrument: unbekannt, Sonnenbild D = 25 cm
Preisbuch
Creators: name: W. Sarasin & Co
Publisher: name: [s.n.]
Year: 1903

description: Trägermaterial: Papier, Textilie
description: Deutsch
description: Verzeichnung=Description=Inventaire 05.10.2022 Automatisierter Import Archivbestand
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
title: Looking Ahead in Games Research: Entry Points into a Pragmatic Field of Inquiry
Creators: name: Siitonen, Marko
name: de la Hera, Teresa
name: Reer, Felix
Publisher: name: University of Muenster, Institutional Repository MIAMI
Year: 2022
Subjects: subject: 300 Social sciences, Anthropology
subject: 302 Social interaction

description: This thematic issue presents a number of emerging scholarships into the study of digital gaming. The articles are based on a 2019 symposium on game studies hosted by the Digital Games Research section of ECREA. As the phenomena related to digital gaming keep on evolving and emerging, so must research keep up with the times and constantly challenge itself. Whether speaking about validating previously developed research methods, imagining totally new ones, or even challenging the whole philosophy of science on which research is being done, there is a constant need for reappraisal and introspection within games research. As a cultural medium that has become deeply embedded into the social fabric of the 2020s, digital gaming continues to excite and challenge academia. This thematic issue provides a collection of approaches to look into the future that addresses some of the challenges associated with game research.
description: Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
[Schleswiger Dom]
Creators: name: Dreesen, Wilhelm
Publisher: name: [s.n.]
Year: 1894

description: Wilhelm Deesen
description: Es handelt sich bei der Aufnahme um einen Albuminabzug
description: Abzug mit handschriftlicher Notiz auf der Rückseite der Unterlage
description: Der Abzug ist auf Karton montiert
description: Digitalisierung=Digitization=Numérisation Oktober 2024 TIFF
Sonnenfleckenzeichnung Nr. 22915.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 07.10.1968, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
[2 Ansichten von Epidaurus]
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1870

description: [Epidaurus]
description: [Epidaurus (...)]
description: Es handelt sich bei den Fotografien um Albuminabzüge
description: Unbekannte/r Fotograf/in
description: Digitalisierung=Digitization=Numérisation Oktober 2024 TIFF
Sonnenfleckenzeichnung Nr. 22897.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 14.09.1968, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Geology of the San Arroyo gas field Grand County, Utah
Creators: name: Monsalve, Obdulio Alfonso
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences
subject: Utah
subject: Grand County
subject: Natural gas
subject: Thesis and dissertation georeferencing project

description: From the time of its discovery in 1962 the San Arroyo the  Field in Grand County, Utah, has been a source of oil and gas from productive intervals in the Cretaceous Cedar Mountain, Dakota, and Mancos Shale Formations, and in the Late Jurassic Entrada and Morrison Formations.  At present, natural gas is the chief commodity produced from reservoirs along the San Arroyo anticline which is the dominant structure in the field. The productive sandstones are elongate along the regional structural grain and most of them occupy the crestal part of the anticline. Stratigraphic complexity due to eolian, fluvial, and transitional sedimen­tary deposition common in beds of the region, precludes full structural control of the accumulations. The reservoirs are controlled by the local stratigraphy, structure, and morpho­logy of the sandstone bodies within the section.  The Arroyo fault, a new geologic feature disclosed by detailed structural mapping, traverses the northern part of the field from southeast to northwest running along the north flank of the San Arroyo anticline. This fault is important as a structural linkage between the San Arroyo Field and the adjacent Prairie Canyon Field in Garfield County, Colorado.  A slight tectonic event, deduced from the particular distribution of the Buckhorn Conglomerate, is believed to have taken place regionally at the beginning of the Cretaceous this event influenced the orientation of the stream channels along a regional structural grain. It is concluded that: a) a preferential accumulation of gas exists along the length of the sandstone bodies; b) the Arroyo fault conforms to the regional structural pattern and is a potential controlling feature for probable reservoirs at the north border of the San Arroyo Field; c) the difference in quality between the gas produced from the Entrada Sandstone and that produced from the Dakota Sandstone indicates two different sources for the gas contained in these formations.
Sonnenfleckenzeichnung Nr. 22865.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 08.08.1968, erstellt von Johann Dürst
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung Nr. 22905.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 23.09.1968, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
The structuration of campus-community partnership: activities, contradictions, and organizational change
Creators: name: Rausch, Georgi Ann
Publisher: name: University of Utah
Year: 2012
Subjects: Case study
Engaged
Organizational change
Partnership
Qualitative
Structuration

description: In the United States, public universities must negotiate public responsibility with market interests, and are often under suspicion of being businesslike and detached from local community issues and concerns. Campus-community partnerships are gaining traction as a preferable way for public universities to bridge campus and community concerns. This dissertation is a qualitative case study of UPartner (UP), an organization that creates campus-community partnerships between a large public university and a community system identified by that university through a statistical analysis of zip codes that indicated underrepresentation at the university. In this dissertation, I explain my methodological perspective as an engaged advisor. Through in-depth interviews, participant observation, and historical research, I engaged with UP to understand how participants characterized their activities and strategized ways to change the university system.  Using structuration theory as a framework, I explain how UP participants structure their activities and characterize the systems of campus and community. I discuss several discursive patterns and practices including Connection, Hopeland, Confusion, and Not Service/Outreach. I also discuss these patterns in light of their enabling and constraining qualities, and the extent to which they echo larger discourses concerning democracy and the market. I give particular focus to the activity of partnership, which is structured as Reciprocity, Sustainability, and Difficulty. Finally, I extend structurating activity theory's notion of contradictions to discuss several contradictions that UP participants encounter when trying to change the university system, including Deficit Discourses, The Marginalization of Community Based Research, and The Containment of UP. I explain each contradiction, and then show how UP participants attempt to overcome the contradiction through desired new discursive patterns.
[3 Ansichten von Korinth]
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1870

description: [Canal von Korinth]
description: [Korinth]
description: Es handelt sich bei den Fotografien um Albuminabzüge
description: Unbekannte/r Fotograf/in
description: Digitalisierung=Digitization=Numérisation Oktober 2024 TIFF
De quelques collaborations inspirantes entre services de documentation et services d'archives
Creators: name: Clot, Nathalie
name: Hamard, Damien
name: Laforêt, Alice
name: Naddéo, Etienne
name: Saussereau, Pauline
Publisher: name: Zenodo
Year: 2022
Subjects: Abes, jabes 22, Journées Abes 2022

description: Journées Abes 2022, 22 juin, de quelques collaborations inspirantes entre services de documentation et services d'archives
 Les missions et services dédiés aux archives, de création souvent récente au sein des établissements documentaires de l’ESR, invitent les bibliothécaires à reconsidérer le périmètre de leur fonds, prendre conscience de pratiques professionnelles spécifiques et porter un regard neuf sur les services au public.
 À mesure que les fonctions archivistiques s’affirment et que leurs activités se déploient, émergent des perspectives de collaborations stimulantes entre professionnels de la documentation et des archives. Session parallèle, coordination : Etienne Naddeo, Abes Intervenants :
 Nathalie Clot, directrice, SCDA de l’Université d’Angers
 Damien Hamard, directeur-adjoint en charge du pôle Archives etRecherche, SCDA de l’Université d’Angers
 Alice Laforêt, adjointe à la cheffe du service Collecte, Traitement et Flux, MNHN
 Pauline Saussereau, archiviste au service Collecte, Traitement et Flux, MNHN
Reaction products of hexamethylene diisocyanate vapors with “self” molecules in the airways of rabbits exposed via tracheostomy
Creators: name: Wisnewski, Adam V.
name: Kanyo, Jean
name: Asher, Jennifer
name: Goodrich, James A.
name: Barnett, Grace
name: Patrylak, Lyn
name: Liu, Jian
name: Redlich, Carrie A.
name: Nassar, Ala F.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: Science Policy

description: 1. Hexamethylenediisocyanate (HDI) is a widely used aliphatic diisocyanate and a well-recognized cause of occupational asthma. 2. “Self” molecules (peptides/proteins) in the lower airways, susceptible to chemical reactivity with HDI, have been hypothesized to play a role in asthma pathogenesis and/or chemical metabolism, but remain poorly characterized. 3. This study employed unique approaches to identify and characterize “self” targets of HDI reactivity in the lower airways. Anesthetized rabbits free breathed through a tracheostomy tube connected to chambers containing either, O2, or O2 plus ∼200 ppb HDI vapors. Following 60 minutes of exposure, the airways were lavaged and the fluid was analyzed by LC-MS and LC-MS/MS. 4. The low-molecular weight (<3 kDa) fraction of HDI exposed, but not control rabbit bronchoalveolar lavage (BAL) fluid identified 783.26 and 476.18 m/z [M+H]+ ions with high energy collision-induced dissociation (HCD) fragmentation patterns consistent with bis glutathione (GSH)-HDI and mono(GSH)-HDI. Proteomic analyses of the high molecular weight (>3 kDa) fraction of exposed rabbit BAL fluid identified HDI modification of specific lysines in uteroglobin (aka clara cell protein) and albumin. 5. In summary, this study utilized a unique approach to chemical vapor exposure in rabbits, to identify HDI reaction products with “self” molecules in the lower airways.
Effects of caffeine on the intracellular distribution of calcium in frog sartorius muscle
Creators: name: Borys, Henry Klymens
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Frogs

description: The influence of caffeine on the intracellular distribution of calcium in the frog sartorius muscle was studied by differential centrifugation in an attempt to identify the locus of action of this alkaloid. The problem was approached in two ways. In the first, the locus of action was sought by relating the kinetic functions of 45Ca washout curves of muscles to changes in the distribution of 45Ca in the isolated fractions from the same muscles. It was not possible to make any correlation of the 45Ca washout curves to the activity in the fractions; the relative distribution of this nuclide remained essentially unchanged at 1-, 2-, and 3-hour intervals along the curve.   The washout curves appear to be the net effect of a complex interaction of the calcium in pools containing both readily exchangeable calcium and calcium which has a slow exchange or turnover rate. The second approach centered upon the examination of the effect of caffeine on the intracellular distribution of 45Ca and of calcium among the cellular fractions.  Caffeine treatment resulted in a distinct increase in the calcium content of the mitochondrial fraction and a decrease in the calcium of the microsomal fraction. Electron micrographic studies revealed significant morphological changes in the whole muscle and in the isolated mitochondrial fraction after the muscle had been exposed to caffeine in a concentration producing irreversible contracture or rigor (10 mM). The increase in calcium content of the mitochondrial fraction after caffeine treatment may be due to an actual accumulation of calcium by the mitochondria or may be the consequence of the appearance of granular vesicles in the fraction.
Fotografische Sonnenaufnahme und zugehörige Zeichnung, unnummeriert, einen Zürcher Lückentag ergänzend.
Fotoabzug und durchgepauste Zeichnung der Aufnahme von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 17.12.1968, fotografiert von John S. Korintus
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Der Abzug ist auf der Rückseite mit genauen Angaben versehen. Flecken und Fackelflächen sind auf das Pauspapier übertragen. Im Jahresbericht für das vorliegende Jahr ist John S. Korintus nicht erwähnt
title: Agilisierung des Projektportfoliomanagements
title: Praktiken und Rollen für traditionelle Unternehmen
titleType: AlternativeTitle
Creators: name: Hüsselmann, Claus
name: Maibach, Marco
Publisher: name: Technische Hochschule Mittelhessen; Gießen
Year: 2020
Subjects: Projektportfoliomanagement
Projektmanagement
Agilisierung
VUCA
Transformation
Lean
SAFe

description: Volatilität, Unsicherheit, Komplexität und Ambiguität zeichnen unsere heutige Zeit aus. Unter dem Akronym VUCA wird diese Entwicklung zusammengefasst. Sie hat weitreichende Auswirkungen auf die Wirtschaft. Klassische Strukturen und Vorgehensweisen können nicht auf diese Dynamik reagieren und verlieren in diesem Zusammenhang ihre Wirkung. Im Projektmanagement wurde in Form der agilen Denkweise eine passende Antwort gefunden, die es ermöglicht, kurzfristig Handlungsfähigkeit sicherzustellen und damit Projekte auch im VUCA-Umfeld erfolgreich umzusetzen. Für moderne Unternehmen existieren darüber hinaus Frameworks, die die Agilität auch auf das PPM skalieren (zum Beispiel SAFe). Allerdings benötigt es dafür bereits ein solides agiles Fundament, welches klassische Unternehmen nicht vorweisen können. Damit aber auch diese klassischen Unternehmen ihr PPM agilisieren können, werden in diesem Report verschiedene Möglichkeiten und Methoden herausgearbeitet, um die Flexibilität und Handlungsfähigkeit in einem dynamischen Umfeld zu verbessern.
Endertiins A-B, two lanostane triterpenoids from the fruit bodies of the mushoom Humphreya endertii
Creators: name: Quang, Dang Ngoc
name: Long, Le Duc
name: Tung, Nguyen Quang
name: Thanh, Nguyen Ngoc
name: Tham, Le Xuan
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Plant Biology

description: Two new lanostane triterpnenoids named endertiins A and B (1 and 2) together with two known compounds as ganodecalone A (3) and ergosterol (4) have been successfully isolated from the cultivated fruit bodies of the mushroom Humphreya endertii Stey (Ganodermataceae). Their structures were elucidated by a combination of HR-MS and 2 D NMR spectroscopic analyses. In addition, endertiins A and B (1 and 2) were evaluated their cytotoxicity against two cancer cell lines, MCF7 (human breast carcinoma) and LU (human lung carcinoma). The result showed that endertiin A (1) could inhibit the growth of MCF-7 cells with its IC50 value of 71.16 ± 6.25 µg/ml.
New insights in the metabolism of oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone
Creators: name: Aprile, Silvio
name: Canavesi, Rossana
name: Matucci, Rosanna
name: Bellucci, Cristina
name: Grosso, Erika Del
name: Grosa, Giorgio
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Marine Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: 1. Oxybutynin hydrochloride is an antimuscarinic agent prescribed to patients with an overactive bladder (OAB) and symptoms of urinary urge incontinence. Oxybutynin undergoes pre-systemic metabolism, and the N-desethyloxybutynin (Oxy-DE), is reported to have similar anticholinergic effects. 2. We revisited the oxidative metabolic fate of oxybutynin by liquid chromatography–tandem mass spectrometry analysis of incubations with rat and human liver fractions, and by measuring plasma and urine samples collected after oral administration of oxybutynin in rats. This investigation highlighted that not only N-deethylation but also N-oxidation participates in the clearance of oxybutynin after oral administration. 3. A new metabolic scheme for oxybutynin was delineated, identifying three distinct oxidative metabolic pathways: N-deethylation (Oxy-DE) followed by the oxidation of the secondary amine function to form the hydroxylamine (Oxy-HA), N-oxidation (Oxy-NO) followed by rearrangement of the tertiary propargylamine N-oxide moiety (Oxy-EK), and hydroxylation on the cyclohexyl ring. 4. The functional activity of Oxy-EK was investigated on the muscarinic receptors (M1-3) demonstrating its lack of antimuscarinic activity. 5. Despite the presence of the α,β-unsaturated function, Oxy-EK does not react with glutathione indicating that in the clearance of oxybutynin no reactive and potentially toxic metabolites were formed.
Qualitative analysis of the acetogenins from Annona coriacea (Annonaceae) leaves by HPLC-Q-Orbitrap and their antibacterial potential against oral pathogens
Creators: name: Terezan, Ana Paula
name: Junqueira, João Gabriel M.
name: Wakui, Vinícius G.
name: Kato, Lucilia
name: Oliveira, Cecília Maria A.
name: Martins, Carlos Henrique G.
name: Santiago, Mariana B.
name: Severino, Vanessa Gisele P.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified

description: Araticum is an edible and appreciable fruit of Annona coriacea, which is popularly known as a traditional herb in the Brazilian cerrado. A phytochemical study from the leaves of A. coriacea showed that HPLC-ESI-Q-Orbitrap® provided through PRM experiments (MS2) is an efficient method for the fast and accurate analysis of a complex mixture of annonaceous acetogenins, with the identification of sylvaticin and gigantetrocin-A type acetogenins for the first time. In addition, the crude leaf extract and acetogenin-rich fractions were assayed against Streptococcus mutans, S. mitis, S. sanguinis and S. salivarius strains, which are usually related to oral infections.
MondoA: Characterization and functional analysis of a novel member of the Myc family of basic-helix-loop-helix-leucine zipper transcription factors
Creators: name: Sans, Christopher Lee
Publisher: name: University of Utah
Year: 2012
Subjects: Helix-Loop-Helix Motifs
Proteins
Protamines
Transcription Factors

description: Transcription factors can be sequestered at specific organelles and translocate to the nucleus only in response to specific extra- or intracellular signals or changes in organellar homeostasis, a process known as retrograde communication. Retrograde communication is becoming a developing signaling paradigm and, in several cases, specific transcription factors associate with organelles and translocate to the nucleus to communicate information about the functional state of the organelle. Subsequently, transcriptional activation or repression typically establishes adaptive positive or negative regulatory feedback circuits, resulting in maintenance of cellular homeostasis. MondoA is a basic helix-loop-helix leucine zipper transcriptional activator similar to Myc in function. However, unlike Myc, MondoA and its binding partner Mlx localize to the cytoplasm, suggesting tight regulation of their nuclear function. We have shown that endogenous MondoA and Mlx associate with the outer mitochondrial membrane through interactions with a protein partner. This association is dynamic, as MondoA shuttles between the mitochondria and the nucleus in a leptomycin B-sensitive fashion, suggesting that it may communicate information between these two organelles. When nuclear, MondoA is capable of activating the transcription of a broad spectrum of metabolic genes, including the glycolytic enzymes lactate dehydrogenase A, hexokinase II, and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3. MondoA directly regulates these genes through interactions with CACGTG E-box consensus sites in their promoters. Consistent with a role for MondoA in regulating glycolysis, upregulated. MondoA increases the glycolytic rate of cells, and MondoA is both necessary and sufficient to drive glycolysis in normal cells. We propose that MondoA communicates information about the intracellular energy state between the mitochondria and the nucleus, resulting in transcriptional activation of glycolytic target genes. We have found that levels of MondoA are controlled by oncogenic Ras in the BJ fibroblast model of tumorigenesis and that oncogenic Ras increases glycolysis in these cells. In the Ras-transformed cells, MondoA directly activates key glycolytic enzymes that have been implicated in contributing to altered metabolism and aerobic glycolysis during cellular transformation, a process known as the 'Warburg effect'. Taken together, we propose that MondoA upregulation by oncogenic Ras contributes to the increased glycolytic rate observed in this model and that MondoA may be an important transcriptional effector in the metabolic switch to aerobic glycolysis during cellular transformation..
Chemical composition of a volatile fraction from the leaves of Clerodendrum infortunatum L.
Creators: name: Gera, Naresh Babu
name: Darshani, Priya
name: P.P., Thasmeer
name: V.S., Pragadheesh
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Hematology
subject: Plant Biology

description: The volatile composition of plants is of great importance because of its wide applications in aromatherapy, pharmaceuticals, perfumes and chemical ecology. This article describes the volatile fraction of Clerodendrum infortunatum L. leaves extracted by partitioning the hydro-distillate using hexane. A fatty acid derivative, 1-octen-3-ol is found as the main component in the volatile fraction ranging from 48.7 to 63.7%. Other compounds found with significant amounts were trans-3-hexenol, 1-hexanol, (3E)-hexen-1-ol acetate, 3-octanone, phenylacetaldehyde, linalool and methyl salicylate. Irregular terpenoid compounds like (E)-β-damascenone, (E)-β-ionone and isophorone are also present in the volatile part of C. infortunatum. The chemical composition of the volatile fraction was identified by spectroscopic analysis, GC and GC-MS.
[6 Ansichten von Mykenä]
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1870

description: [Mykenä]
description: [Mykenä: Königsburg]
description: [Schatzhaus des Atreus in Mykenä]
description: [Löwentor in Mykenä]
description: Es handelt sich bei den Fotografien um Albuminabzüge
description: Unbekannte/r Fotograf/in
description: Digitalisierung=Digitization=Numérisation Oktober 2024 TIFF
Reaction products of hexamethylene diisocyanate vapors with “self” molecules in the airways of rabbits exposed via tracheostomy
Creators: name: Wisnewski, Adam V.
name: Kanyo, Jean
name: Asher, Jennifer
name: Goodrich, James A.
name: Barnett, Grace
name: Patrylak, Lyn
name: Liu, Jian
name: Redlich, Carrie A.
name: Nassar, Ala F.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: Science Policy

description: 1. Hexamethylenediisocyanate (HDI) is a widely used aliphatic diisocyanate and a well-recognized cause of occupational asthma. 2. “Self” molecules (peptides/proteins) in the lower airways, susceptible to chemical reactivity with HDI, have been hypothesized to play a role in asthma pathogenesis and/or chemical metabolism, but remain poorly characterized. 3. This study employed unique approaches to identify and characterize “self” targets of HDI reactivity in the lower airways. Anesthetized rabbits free breathed through a tracheostomy tube connected to chambers containing either, O2, or O2 plus ∼200 ppb HDI vapors. Following 60 minutes of exposure, the airways were lavaged and the fluid was analyzed by LC-MS and LC-MS/MS. 4. The low-molecular weight (<3 kDa) fraction of HDI exposed, but not control rabbit bronchoalveolar lavage (BAL) fluid identified 783.26 and 476.18 m/z [M+H]+ ions with high energy collision-induced dissociation (HCD) fragmentation patterns consistent with bis glutathione (GSH)-HDI and mono(GSH)-HDI. Proteomic analyses of the high molecular weight (>3 kDa) fraction of exposed rabbit BAL fluid identified HDI modification of specific lysines in uteroglobin (aka clara cell protein) and albumin. 5. In summary, this study utilized a unique approach to chemical vapor exposure in rabbits, to identify HDI reaction products with “self” molecules in the lower airways.
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 02.11.1968, erstellt von Dendis am Skalnate Pleso Observatorium
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage am Skalnate Pleso Observatorium. Es sind zudem statistische Angaben für die Bestimmung der Fleckenrelativzahl notiert. Instrument: unbekannt, Sonnenbild D = 25 cm
Two new pyranoxanthones from the stem bark of Calophyllum pseudomolle P.F. Stevens
Creators: name: Tanjung, Mulyadi
name: Tjahjandarie, Tjitjik Srie
name: Saputri, Ratih Dewi
name: Aldin, Muhammad Fajar
name: Purnobasuki, Hery
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Two new pyranoxanthones, calotetrapterins D (1) and E (2), were isolated from the stem bark of Calophyllum pseudomolle P.F. Stevens along with α-mangostin (3). The structures of compounds 1–2 were determined based on 1D NMR (1H, 13C) and 2D NMR (HMQC, HMBC), as well as HRESIMS spectroscopic analysis. Compounds 1–2 showed moderate activity against HeLa and murine leukaemia P-388 cells.
[3 Ansichten von Nauplia]
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1870

description: [Nauplia]
description: Es handelt sich bei den Fotografien um Albuminabzüge
description: Unbekannte/r Fotograf/in
description: Digitalisierung=Digitization=Numérisation Oktober 2024 TIFF
Diurnal variation of blood leucocytes in normal and adrenalectomized mice
Creators: name: Brown, Herbert Ensign
Publisher: name: University of Utah
Year: 2012
Subjects: Hematocrit
Adrenalectomy

description: In these experiments the normal variations in the absolute number and percentages of the blood leucocytes over a 24 hour period were studied in intact and adrenalectomized mice.  1. A diurnal variation of large magnitude occurs in the number of blood leucocytes obtained from the tail vein blood of mice.  The diurnal cycle is characterized by high leucocyte levels during the late morning and early afternoon which is the least active period in this nocturnal animal, and by low levels during the late evening which is the most active period.  2. Although, large variations were observed for the absolute numbers of leucocytes, only minor variation were observed in the percentages of leucocytes present in tail vein blood during the normal diurnal cycle.  The apparent diphasic nature of the total lymphocyte percentage curve can be explained by the inverse relationship between the normal and acytoplasmic lymphocytes.  The percentage curve of the eosinophils resembles that of the acytoplasmic lymphocytes, and the percentage curves and absolute numbers of the stress lymphocytes and neutrophils are very similar.  3.  Hemodilution or hemoconcentration does not appear to be a major factor in the leucocyte variations.  Although a small day and night variation in hematocrit was observed it was not large enough to account for the magnitude of the leucocyte variations.  4. Adrenalectomy appears to abolish the diurnal variation of the circulating leucocytes since no day and night differences were observed in a 14 day period after the adrenal glands were removed.  5. The leucocyte count after adrenalectomy assumes levels which are characteristic for the high period of the normal diurnal cycle.  A slight exception is noted for the eosinophils which maintain a level intermediate between normal high and low values and for the normal lymphocytes which show a slight lymphocytosis of these two periods.  6. The leucocyte variation during the diurnal cycle in mice correlate will with other indices of adrenal function.  Since adrenalectomy abolishes these variation, it is apparent that they are mediated through the action of the adrenal hormones.  Diurnal variations for eosinophils and total lylmphocytes have been observed in humans, and the eosinophil variations have been reported to be markedly reduced in Addison's Disease and panhypopituitarism.  More work in needed, however, to work out the details of human leucocyte variations.  Work of this nature would be a big aid in hematological diagnosis.  7. These results illustrate that in experimental work which is concerned with measuring changes in the number of circulating leucocytes, the interpretations of results must take into consideration normal diurnal variations or the data will reflect not only experimental differences but normal diurnal changes as well.
Sonnenfleckenzeichnung Nr. 22920.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 12.10.1968, erstellt von Antoine Zelenka
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 04.11.1968, erstellt am Kandilli Observatorium Istanbul
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Istanbul Kandilli Rasathanesi, Çengelköy (Istanbul). Instrument: Refraktor Teleskop (Öffnung 200 mm, f = 3070 mm, projiziertes Sonnenbild D = 25 cm).
Instrumentennachweis gemäss Kandilli Observatory Istanbul, Report from Solar Institute, in: Solar Physics, 1968, Vol. 3, Issue 3, pp.491-492, DOI: https://doi.org/10.1007/BF00171622
title: Discussing pottery standards – an everlasting story? Proposal of a basic recording system for African ceramics
title: Discussing pottery standards – an everlasting story? Proposal of a basic recording system for African ceramics
titleType: Subtitle
Creators: name: Jesse, Friederike
name: Nowotnick, Ulrike
Publisher: name: Deutsches Archäologisches Institut
Year: 2022
Subjects: subject: Africa, Pottery, Recording scheme, Decoration

description: Journal of Global Archaeology, 2021
description: We present here a recording scheme for archaeological ceramics in Africa. This is an outcome of workshop discussions within the priority program Entangled Africa and is put up as methodological report for further discussion. It is hoped that other projects will be interested in expanding its data with further materials and thus contribute to a broader interdisciplinary exchange on African pottery.
[3 Ansichten von Olympia]
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1870

description: [Olympia. Zeustempel im Vordergrund]
description: [Olympia]
description: [Olympia. Hermes mit dem Dionysoskind]
description: Es handelt sich bei den Fotografien um Albuminabzüge
description: Unbekannte/r Fotograf/in
description: Digitalisierung=Digitization=Numérisation Oktober 2024 TIFF