cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Otomys zinki Bohmann 1943
Creators: name: Taylor, Peter J.
name: Lavrenchenko, Leonid A.
name: Carleton, Michael D.
name: Verheyen, Erik
name: Bennett, Nigel C.
name: Oosthuizen, Carel J.
name: Maree, Sarita
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Muridae
Otomys
Otomys zinki

description: Otomys zinki Bohmann, 1943
 Otomys typus zinki; Bohmann, 1943:153 (type locality— German East Africa [Tanzania], Kilimanjaro, Peters Hut, 3800 m; holotype —not seen; listed as “No. 548” in his private collection by Bohmann, 1943); Swynnerton and Hayman, 1951:321 (faunal report, listed as valid subspecies); Bohmann, 1952:41 (taxonomic revision, retained as valid subspecies).
 Otomys typus [zinki]; Misonne, 1974:33 (listed in synonymy without indication of rank); Musser & Carleton, 1993:682 (listed in synonymy without indication of rank).
 Otomys orestes [zinki]; Musser & Carleton, 2005:1528 (new name combination, listed in synonymy without indication of rank).
 Distribution. The species is limited in its distribution to Mt Kilimanjaro.
 Specimens examined. TANZANIA: Kilimanjaro (SM 4270, 4272, 4278, 4280); Mount Kilimanjaro East, Maundi Crater, grassland, 3270 m (RMCA 96.037.M-6801, 96.037.M-6802, 96.037.M-6803, 96.037.M-6804, 96.037.M-6805, 96.037.M-6801); Mount Kilimanjaro West, Londorosi, forest, 2350 m (96.037.M-6807, 96.037.M-6810); Mount Kilimanjaro West, Shira, moorland, 3000 m (96.037.M-6809); Mount Kilimanjaro, Kilimanjaro National Park, 13,100 ft (3993 m) (FMNH 174178–174180); Mount Kilimanjaro, Kilimanjaro National Park, 7 km N and 2.5 km W Maua, 8,100 ft (2469 m) (FMNH 174173, 174174).
description: Published as part of Taylor, Peter J., Lavrenchenko, Leonid A., Carleton, Michael D., Verheyen, Erik, Bennett, Nigel C., Oosthuizen, Carel J. & Maree, Sarita, 2011, Specific limits and emerging diversity patterns in East African populations of laminate-toothed rats, genus Otomys (Muridae: Murinae: Otomyini): Revision of the Otomys typus complex 3024, pp. 1-66 in Zootaxa 3024 (1) on page 53, DOI: 10.11646/zootaxa.3024.1.1, http://zenodo.org/record/5280584
How Is Multinational Investment in Grain and Oilseed Trading Reshaping the Smallholder Markets in Zambia?
Creators: name: Sitko, Nicholas J.
name: Chisanga, Brian
name: Sitko, Nicholas J.
name: Chisanga, Brian
Publisher: name: Unknown
Year: 2016
Subjects: Agricultural and Food Policy
Demand and Price Analysis
International Development

description: African agrifood systems are being transformed by an influx of multinational capital. Research on this transformation focuses primarily on the rise of supermarkets and demand for African land. An under-appreciated facet of this transformation is multinational investment in African grain trading. This paper uses basic descriptive statistical data and qualitative evidence to examine the implications of the recent multinational investment wave into cereal and oilseed trading in Zambia.
Gap Symmetry an Thermal Conductivity in Nodal Superconductors
Creators: name: Thalmeier, P.
name: Maki, K.
Publisher: name: arXiv
Year: 2001
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: There are now many nodal superconductors in heavy fermion (HF) systems, charge conjugated organic metals, high Tc cuprates and ruthenates. On the other hand only few of them have a well established gap function. We present here a study of the angular dependent thermal conductivity in the vortex state of some of the nodal superconductors. We hope it will help to identify the nodal directions in the gap function of UPd_2Al_3, UNi_2Al_3, UBe_13 and URu_2Si_2.
description: 4 pages, 5 figures
• A profitability analysis of fertilizer use for maize production in Nigeria
Creators: name: Liverpool-Tasie, L. S. O.
name: Omonona, B.T.
name: Sanou, A.
name: Ogunleye, W.
name: Liverpool-Tasie, L. S. O.
name: Omonona, B.T.
name: Sanou, A.
name: Ogunleye, W.
Publisher: name: Unknown
Year: 2016
Subjects: Food Security and Poverty

description: Inorganic fertilizer use across sub Saharan Africa is generally considered to be low. Yet, the notion that fertilizer use is too low is predicated on the assumption that it is profitable to use rates higher than currently observed if indeed we consider rural farmers to be rationale expected profit maximizes. As a result of this assumption, the literature generally looks to other constraints to its adoption (financial market imperfections (credit/insurance/savings), knowledge, or lack of demand and thus the realization of economies of scale on the supply side (agro-dealer network), or lack of access to markets to sell the produce, but these all link again to profitability issues. Consequently this brief summarizes a study that focuses on the profitability of fertilizer use as a likely explanatory factor for observed fertilizer use rates in Nigeria.
MOESM17 of Small RNA and degradome deep sequencing reveal respective roles of cold-related microRNAs across Chinese wild grapevine and cultivated grapevine
Creators: name: Pengfei Wang
name: Yang, Yang
name: Hongmei Shi
name: Yongmei Wang
name: Fengshan Ren
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Plant Biology

description: Additional file 17: Table S17. Significantly enriched GO terms of targets of DEMs in cultivated and Chinese wild grape.
Nanomaterials-Mediated Immunomodulation for Cancer Therapeutics
Creators: name: Jindal, Ajita
name: Sarkar, Sounik
name: Alam, Aftab
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Chemistry
cancer
nanomaterials
immunomodulation
therapeutics
immunotherapy

description: Immunotherapy holds great promise in overcoming the limitations of conventional regimens for cancer therapeutics. There is growing interest among researchers and clinicians to develop novel immune-strategies for cancer diagnosis and treatment with better specificity and lesser adversity. Immunomodulation-based cancer therapies are rapidly emerging as an alternative approach that employs the host’s own defense mechanisms to recognize and selectively eliminate cancerous cells. Recent advances in nanotechnology have pioneered a revolution in the field of cancer therapy. Several nanomaterials (NMs) have been utilized to surmount the challenges of conventional anti-cancer treatments like cytotoxic chemotherapy, radiation, and surgery. NMs offer a plethora of exceptional features such as a large surface area to volume ratio, effective loading, and controlled release of active drugs, tunable dimensions, and high stability. Moreover, they also possess the inherent property of interacting with living cells and altering the immune responses. However, the interaction between NMs and the immune system can give rise to unanticipated adverse reactions such as inflammation, necrosis, and hypersensitivity. Therefore, to ensure a successful and safe clinical application of immunomodulatory nanomaterials, it is imperative to acquire in-depth knowledge and a clear understanding of the complex nature of the interactions between NMs and the immune system. This review is aimed at providing an overview of the recent developments, achievements, and challenges in the application of immunomodulatory nanomaterials (iNMs) for cancer therapeutics with a focus on elucidating the mechanisms involved in the interplay between NMs and the host’s immune system.
Tolerability, safety, and pharmacokinetics of GR1603 injection in healthy subjects: a randomized, double-blind, placebo-controlled single-dose escalation clinical trial
Creators: name: Huang, Xin
name: Hong, Xiang
name: Yang, Shuang
name: Ye, Ling
name: Yang, Xiaoyan
name: Cui, Chang
name: Wu, Qian
name: Wang, Wei
name: Huang, Jie
name: Yang, Guoping
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: GR1603 is a monoclonal antibody targeting the type I interferon receptor. The aim of this study was to evaluate the safety, tolerability, pharmacokinetics, immunogenicity and pharmacodynamics of GR1603 in healthy volunteers. Healthy adults (≥18 years old) were enrolled in a placebo control, dose-escalation Phase I clinical trial receiving a single injectable dose of GR1603. Follow-up was 12 weeks. Adverse event (AE) profiles, vital signs, and blood samples were collected for assessment of safety, PK, and expression of type I interferon inducible genes. Of the 46 subjects, 44 completed treatment. In the experimental group of 34 subjects (mean age 26.6 years), 30 experienced treatment-emergent adverse events (TEAEs), with a total of 102 occurrences, resulting in an incidence rate of 88.2%. The most commonly reported drug-related AEs were upper respiratory tract infection (17.6%), all of which were ≤ grade 2. GR1603 exhibits non-linear PK in the dose range of 0.1 mg/kg to 9 mg/kg. All samples were negative for anti-drug antibodies before and after dosing. The degrees of IFN gene signature were significantly inhibited in the higher dose groups. The safety/tolerability, PK and exploratory metrics observed in this study support further clinical development of GR1603. www.chictr.org.cn/searchproj.html identifier is ChiCTR2100045628.
A pilot study evaluating GSK1070806 inhibition of interleukin-18 in renal transplant delayed graft function
Creators: name: Wlodek, E.
name: Kirkpatrick, R. B.
name: Andrews, S.
name: Noble, R.
name: Schroyer, R.
name: Scott, J.
name: Watson, C. J. E.
name: Clatworthy, M.
name: Harrison, E. M.
name: Wigmore, S. J.
name: Stevenson, K.
name: Kingsmore, D.
name: Sheerin, N. S.
name: Bestard, O.
name: Stirnadel-Farrant, H. A.
name: Abberley, L.
name: Busz, M.
name: DeWall, S.
name: Birchler, M.
name: Krull, D.
name: Thorneloe, K. S.
name: Weber, A.
name: Devey, L.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Research Article
Medicine and health sciences
Biology and life sciences
Research and analysis methods

description: Funder: GlaxoSmithKline; funder-id: http://dx.doi.org/10.13039/100004330
description: Introduction: Delayed graft function (DGF) following renal transplantation is a manifestation of acute kidney injury (AKI) leading to poor long-term outcome. Current treatments have limited effectiveness in preventing DGF. Interleukin-18 (IL18), a biomarker of AKI, induces interferon-γ expression and immune activation. GSK1070806, an anti-IL18 monoclonal antibody, neutralizes activated (mature) IL18 released from damaged cells following inflammasome activation. This phase IIa, single-arm trial assessed the effect of a single dose of GSK1070806 on DGF occurrence post donation after circulatory death (DCD) kidney transplantation. Methods: The 3 mg/kg intravenous dose was selected based on prior studies and physiologically based pharmacokinetic (PBPK) modeling, indicating the high likelihood of a rapid and high level of IL18 target engagement when administered prior to kidney allograft reperfusion. Utilization of a Bayesian sequential design with a background standard-of-care DGF rate of 50% based on literature, and confirmed via extensive registry data analyses, enabled a statistical efficacy assessment with a minimal sample size. The primary endpoint was DGF frequency, defined as dialysis requirement ≤7 days post transplantation (except for hyperkalemia). Secondary endpoints included safety, pharmacokinetics and pharmacodynamic biomarkers. Results: GSK1070806 administration was associated with IL18-GSK1070806 complex detection and increased total serum IL18 levels due to IL18 half-life prolongation induced by GSK1070806 binding. Interferon-γ−induced chemokine levels declined or remained unchanged in most patients. Although the study was concluded prior to the Bayesian-defined stopping point, 4/7 enrolled patients (57%) had DGF, exceeding the 50% standard-of-care rate, and an additional two patients, although not reaching the protocol-defined DGF definition, demonstrated poor graft function. Six of seven patients experienced serious adverse events (SAEs), including two treatment-related SAEs. Conclusion: Overall, using a Bayesian design and extensive PBPK dose modeling with only a small sample size, it was deemed unlikely that GSK1070806 would be efficacious in preventing DGF in the enrolled DCD transplant population. Trial registration: NCT02723786.
New data and the hard pomeron
Creators: name: Donnachie, A
name: Landshoff, P V
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: New structure-function data are in excellent agreement with the existence of a hard pomeron, with intercept about 1.4. It gives a very economical description of the data. Having fixed 2 parameters from the data for the real-photon cross section $σ^{γp}$, we need just 5 further parameters to fit the data for $F_2(x,Q^2)$ with $x\leq 0.001$. The available data range from $Q^2=0.045$ to 35 GeV$^2$. With guesses consistent with dimensional counting for the $x$ dependences of our three separate terms, the fit extends well to larger $x$ and to $Q^2=5000$ GeV$^2$. With no additional parameters, it gives a good description of data for the charm structure function $F_2^c(x,Q^2)$ from $Q^2=0$ to 130 GeV$^2$. The two pomerons also give a good description of both the $W$ and the $t$ dependence of $γp\to J/ψp$.
description: 11 pages, plain tex, with 10 figures embedded using epsf. (Spurious figure removed.)
MOESM2 of Short-term inhibition of glutamine synthetase leads to reprogramming of amino acid and lipid metabolism in roots and leaves of tea plant (Camellia sinensis L.)
Creators: name: Mei-Ya Liu
name: Dandan Tang
name: Yuanzhi Shi
name: Lifeng Ma
name: Li, Yan
name: Qunfeng Zhang
name: Jianyun Ruan
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Plant Biology
subject: 60506 Virology

description: Additional file 2: Table S2. Results of de novo assembly of transcriptome data and tea plant unigenes.
Reproducible Research: Best Practices and Potential Misuse
Creators: name: Björnson, Emil
Publisher: name: arXiv
Year: 2019
Subjects: subject: Signal Processing (eess.SP)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: The scientific world is becoming more open to the public and fellow researchers. Open access publishing is becoming accepted, even if some publishers are resisting. The next step is the open code and data paradigm, which was briefly discussed in the "From the Editor" column in the November 2018 issue of IEEE Signal Processing Magazine (SPM) [1]. In this column, I follow up on this topic by sharing my experiences, best practices, and thoughts about reproducible research.
description: 10 pages, 1 figure
Update on very light CP-odd scalar in the Two-Higgs-Doublet Model
Creators: name: Larios, F.
name: Tavares-Velasco, G.
name: Yuan, C. -P.
Publisher: name: arXiv
Year: 2002
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In a previous work we have shown that a general two-Higgs-doublet model (THDM) with a very light CP-odd scalar can be compatible with electroweak precision data, such as the rho parameter, BR(b --> s gamma), R_b, A_b, BR(Upsilon --> A gamma), BR(eta --> A gamma), and (g-2) of muon. Prompted by the recent significant change in the theoretical status of the latter observable, we comment on the consequences for this model and update the allowed parameter region. It is found that the presence of a very light scalar with a mass of 0.2 GeV is still compatible with the new theoretical prediction of the muon anomalous magnetic moment.
description: 10 pages, 11 figures, uses REVTEX 4, including updated figures and discussion considering the latest muon (g-2) data
Is Fertilizer use Inconsistent with Expected Profitability for Rice Production in Nigeria?
Creators: name: Liverpool-Tasie, L. S. O.
name: Liverpool-Tasie, L. S. O.
Publisher: name: Unknown
Year: 2016
Subjects: Food Security and Poverty

description: This brief presents empirical results that revisit a conventional wisdom that inorganic fertilizer use across sub-Saharan Africa is too low. This expectation that more farmers should be using inorganic fertilizer and at higher rates implies it is profitable to use rates higher than observed if farmers are rational expected profit maximizers. This study exploits the political economy of fertilizer access in Nigeria to get consistent estimates of the effects of applied nitrogen on rice production.
Evaluation of pharmacokinetic and pharmacodynamic similarity of an IDegAsp biosimilar versus the originator in healthy Chinese volunteers
Creators: name: Liu, Hui
name: Xiong, Yang
name: Chen, Xinlei
name: Yu, Hongling
name: Lan, Li
name: He, Wengang
name: Wang, Wenjia
name: Zhuang, Yulei
name: Deng, Li
name: Huang, Kanghua
name: Guo, Linfeng
name: Yu, Yerong
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health

description: 22011 is an insulin degludec/insulin aspart co-formulation (IDegAsp) that shares an identical amino acid sequence with Ryzodeg, the originator IDegAsp. This study aimed to compare the pharmacokinetics (PK), pharmacodynamics (PD), and safety of 22011 with Ryzodeg. In a single-center, randomized, open-label, two-treatment, two-period, two-sequence, crossover, euglycemic clamp study, healthy Chinese adults were randomized to receive 0.5 U/kg of 22011 and Ryzodeg under fasting conditions. PK was evaluated for up to 120 h and PD (represented by glucose infusion rate [GIR]) was assessed for up to 24 h. Of 46 subjects randomized, all completed both treatment periods and were included in the PK/PD and safety analysis set. Insulin exposure (AUCIDeg, 0–24 h, AUCIAsp, 0–12 h, and Cmax, IAsp) and activity (GIRmax and AUCGIR, 0–24 h) were comparable (estimates of treatment ratios 0.916 ~ 1.076 for primary PK parameters and 0.946 ~ 1.037 for primary PD parameters), with 90% confidence intervals for the ratios of least square means falling within the range of 0.80 ~ 1.25. Adverse events were similar for both products and no significant safety concerns were noted in the laboratory results, vital signs, or electrocardiogram. This study demonstrated the PK/PD similarity of 22011 to Ryzodeg with a comparable safety profile. Trial Registration:http://www.chinadrugtrials.org.cn/index.html with an identifier of CTR20230678, registered 15 March 2023.
Sustaining Input on Credit Through Dynamic Incentives and Information Sharing:
Creators: name: Adjognon, S
name: Liverpool-Tasie, S. L.
name: Shupp, R.
name: Adjognon, S
name: Liverpool-Tasie, S. L.
name: Shupp, R.
Publisher: name: Unknown
Year: 2016
Subjects: Food Security and Poverty

description: A Dynamic incentive model is used to develop conditions that minimize strategic default in agricultural inputs on credit to rural smallholder farmers. Hypotheses from the model are tested using data collected through a framed field experiment that simulates a market for input on credit
A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons
Creators: name: Sybirna, Anastasiya
name: Tang, Walfred W. C.
name: Pierson Smela, Merrick
name: Dietmann, Sabine
name: Gruhn, Wolfram H.
name: Brosh, Ran
name: Surani, M. Azim
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Article
/631/1647/1513
/631/136/2434
/631/532/2064
/13
/13/31
/13/1
/13/21
/13/44
/13/100
/13/106
/13/109
/14
/14/19
/38
/38/15
/38/35
/38/77
/38/88
/38/90
/45/91
article

description: Funder: Wellcome Trust (Wellcome); doi: https://doi.org/10.13039/100004440
description: Funder: University of Cambridge | Churchill College, University of Cambridge; doi: https://doi.org/10.13039/501100000742
description: Abstract: PRDM14 is a crucial regulator of mouse primordial germ cells (mPGCs), epigenetic reprogramming and pluripotency, but its role in the evolutionarily divergent regulatory network of human PGCs (hPGCs) remains unclear. Besides, a previous knockdown study indicated that PRDM14 might be dispensable for human germ cell fate. Here, we decided to use inducible degrons for a more rapid and comprehensive PRDM14 depletion. We show that PRDM14 loss results in significantly reduced specification efficiency and an aberrant transcriptome of hPGC-like cells (hPGCLCs) obtained in vitro from human embryonic stem cells (hESCs). Chromatin immunoprecipitation and transcriptomic analyses suggest that PRDM14 cooperates with TFAP2C and BLIMP1 to upregulate germ cell and pluripotency genes, while repressing WNT signalling and somatic markers. Notably, PRDM14 targets are not conserved between mouse and human, emphasising the divergent molecular mechanisms of PGC specification. The effectiveness of degrons for acute protein depletion is widely applicable in various developmental contexts.
Ultradeep Near-Infrared ISAAC Observations of the HDF-S: Observations, Reduction, Multicolor Catalog, and Photometric Redshifts
Creators: name: Labbe, I.
name: Franx, M.
name: Rudnick, G.
name: Schreiber, N. M. Forster
name: van der Werf, P.
name: Rottgering, H.
name: van Starkenburg, L.
name: van de Wel, A.
name: Kuijken, K.
name: Rix, H. -W.
name: Moorwood, A.
name: Daddi, E.
name: van Dokkum, P. G.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present deep near-infrared (NIR) Js, H, and Ks-band ISAAC imaging of the WFPC2 field of the HDF-S. The 2.5'x 2.5' high Galactic latitude field was observed with the VLT under the best seeing conditions with integration times amounting to 33.6 hours in Js, 32.3 hours in H, and 35.6 hours in Ks. We reach total AB magnitudes for point sources of 26.8, 26.2, and 26.2 respectively (3 sigma), which make it the deepest ground-based NIR observations to date, and the deepest Ks-band data in any field. The effective seeing of the coadded images is ~0.45" in Js, ~0.48" in H, and ~0.46" in Ks. Using published WFPC2 optical data, we constructed a Ks-limited multicolor catalog containing 833 sources down to Ks,tot ~< 26 (AB), of which 624 have seven-band optical-to-NIR photometry. These data allow us to select normal galaxies from their rest-frame optical properties to high redshift (z ~< 4). The observations, data reduction and properties of the final images are discussed, and we address the detection and photometry procedures that were used in making the catalog. In addition, we present deep number counts, color distributions and photometric redshifts of the HDF-S galaxies. We find that our faint Ks-band number counts are flatter than published counts in other deep fields, which might reflect cosmic variations or different analysis techniques. Compared to the HDF-N, we find many galaxies with very red V-H colors at photometric redshifts 1.95 < z < 3.5. These galaxies are bright in Ks with infrared colors redder than Js-Ks > 2.3 (in Johnson magnitudes). Because they are extremely faint in the observed optical, they would be missed by ultraviolet-optical selection techniques, such as the U-dropout method.
description: LaTeX, 24 pages, 15 figures, 3 tables. Accepted for publication in the Astronomical Journal. The paper with full resolution images and figures is available at http://www.strw.leidenuniv.nl/~fires/papers/2002Labbe.ps.gz . The reduced data and catalogs can be found at http://www.strw.leidenuniv.nl/~fires/data/hdfs/
Syringogaster atricalyx Marshall & Buck 2009
Creators: name: Rafael, J. A.
name: Câmara, J. T.
name: Holanda, M. J. A.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Syringogastridae
Syringogaster
Syringogaster atricalyx

description: Syringogaster atricalyx Marshall & Buck
 Syringogaster atricalyx Marshall & Buck, 2009 In : Marshall, Buck, Skevington & Grimaldi 2009: 22.
 Geographical records. Bolivia (La Paz), Brazil (Acre, Pará, Amazonas ), Ecuador (Napo), Peru.
 Material examined. Brasil, Acre, Cruzeiro do Sul, Rio Moa, 07º37’02’’S – 72º46’15’’W, 19–28.xi.1996 / Varredura (mata) / J.A. Rafael, J. Vidal & R. L. Menezes. (3 ♂, INPA). Brasil, Amazonas, S. Isabel do R. Negro, Maturacá, 11–13.x.1990 / Arm. Malaise, J.A. Rafael (1 ♂, INPA).
description: Published as part of Rafael, J. A., Câmara, J. T. & Holanda, M. J. A., 2011, A new species of Syringogastridae (Diptera, Acalyptratae) from the Amazon Basin and new records for Brazil, pp. 26-34 in Zootaxa 3014 (1) on page 32, DOI: 10.11646/zootaxa.3014.1.2, http://zenodo.org/record/5280766
Tolerability, safety, and pharmacokinetics of GR1603 injection in healthy subjects: a randomized, double-blind, placebo-controlled single-dose escalation clinical trial
Creators: name: Huang, Xin
name: Xiang, Hong
name: Yang, Shuang
name: Ye, Ling
name: Yang, Xiaoyan
name: Cui, Chang
name: Wu, Qian
name: Wang, Wei
name: Huang, Jie
name: Yang, Guoping
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Neuroscience
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: GR1603 is a monoclonal antibody targeting the type I interferon receptor. The aim of this study was to evaluate the safety, tolerability, pharmacokinetics, immunogenicity and pharmacodynamics of GR1603 in healthy volunteers. Healthy adults (≥18 years old) were enrolled in a placebo control, dose-escalation Phase I clinical trial receiving a single injectable dose of GR1603. Follow-up was 12 weeks. Adverse event (AE) profiles, vital signs, and blood samples were collected for assessment of safety, PK, and expression of type I interferon inducible genes. Of the 46 subjects, 44 completed treatment. In the experimental group of 34 subjects (mean age 26.6 years), 30 experienced treatment-emergent adverse events (TEAEs), with a total of 102 occurrences, resulting in an incidence rate of 88.2%. The most commonly reported drug-related AEs were upper respiratory tract infection (17.6%), all of which were ≤ grade 2. GR1603 exhibits non-linear PK in the dose range of 0.1 mg/kg to 9 mg/kg. All samples were negative for anti-drug antibodies before and after dosing. The degrees of IFN gene signature were significantly inhibited in the higher dose groups. The safety/tolerability, PK and exploratory metrics observed in this study support further clinical development of GR1603.
MOESM1 of The relationship between perfectionism and symptoms of depression in medical school applicants
Creators: name: Bußenius, Lisa
name: Harendza, Sigrid
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1: Table S1. Participants’ characteristics according to the time points of data collection.
Seoul National University AGN Monitoring Project. I. Strategy and Sample
Creators: name: Woo, J. -H.
name: Son, D.
name: Gallo, E.
name: Hodges-Kluck, E.
name: Shin, J.
name: Jeon, Y.
name: Bae, H. -J.
name: Cho, H.
name: Cho, W.
name: Kang, D.
name: Kang, W.
name: Karouzos, M.
name: Kim, M.
name: Kim, T.
name: Le, H. A. N.
name: Park, D.
name: Park, S.
name: Rakshit, S.
name: Sung, H. -I.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: While the reverberation mapping technique is the best available method for measuring black hole mass in active galactic nuclei (AGN) beyond the local volume, this method has been mainly applied to relatively low-to-moderate luminosity AGNs at low redshift. We present the strategy of the Seoul National University AGN Monitoring Project, which aims at measuring the time delay of the \Hb\ line emission with respect to AGN continuum, using a sample of relatively high luminosity AGNs out to z $\sim$0.5. We present simulated cross correlation results based on a number of mock light curves, in order to optimally determine monitoring duration and cadence. We describe our campaign strategy based on the simulation results and the availability of observing facilities. We present the sample selection, and the properties of the selected 100 AGNs, including the optical luminosity, expected time lag, black hole mass, and Eddington ratio.
description: 10 pages, 11 figures, JKAS in press
Fertilizer Use and Farmer Productivity in Nigeria:
Creators: name: Liverpool-Tasie, L. S. L. S.
name: Omonona, B.T.
name: Sanou, A.
name: Ogunleye, W.
name: Liverpool-Tasie, L. S. L. S.
name: Omonona, B.T.
name: Sanou, A.
name: Ogunleye, W.
Publisher: name: Unknown
Year: 2016
Subjects: Food Security and Poverty

description: Increasing the use of modern inputs including fertilizer is key for raising agricultural productivity and reducing poverty in Nigeria, particularly and Africa more generally. However, based on recent empirical evidence from Nigeria, simply increasing the quantity of fertilizer used by smallholders is not likely to successfully drive this process. A more holistic approach that addresses the constraints to fertilizer profitability in Nigeria with appropriate consideration of the factors which will increase the efficiency of fertilizer use is necessary.
Inverse problems for symmetric doubly stochastic matrices whose Suleĭmanova spectra are bounded below by 1/2
Creators: name: Gnacik, Michal
name: Kania, Tomasz
Publisher: name: arXiv
Year: 2019
Subjects: subject: Spectral Theory (math.SP)
subject: Numerical Analysis (math.NA)
subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 65F18 (primary), and 15A18, 15A12 (secondary)

description: A new sufficient condition for a list of real numbers to be the spectrum of a symmetric doubly stochastic matrix is presented; this is a contribution to the classical spectral inverse problem for symmetric doubly stochastic matrices that is still open in its full generality. It is proved that whenever $λ_2, \ldots, λ_n$ are non-positive real numbers with $1 + λ_2 + \ldots + λ_n \geqslant 1/2$, then there exists a symmetric, doubly stochastic matrix whose spectrum is precisely $(1, λ_2, \ldots, λ_n)$. We point out that this criterion is incomparable to the classical sufficient conditions due to Perfect-Mirsky, Soules, and their modern refinements due to Nader et al. We also provide some examples and applications of our results.
description: Accepted to Linear Algebra and Its Applications, pages 12
Additional file 2 of Let-7i-5p enhances cell proliferation, migration and invasion of ccRCC by targeting HABP4
Creators: name: Liu, Yujie
name: Hu, Xing
name: Hu, Liang
name: Xu, Changjing
name: Liang, Xuemei
Publisher: name: figshare
Year: 2021
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 2: Supplementary Table S2: 234 genes that negatively correlated with let-7i-5p expression.
Dispersive readout of a weakly coupled qubit via the parity-time-symmetric phase transition
Creators: name: Zhang, Guo-Qiang
name: Wang, Yi-Pu
name: You, J. Q.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: For some cavity-quantum-electrodynamics systems, such as a single electron spin coupled to a passive cavity, it is challenging to reach the strong-coupling regime. In such a weak-coupling regime, the conventional dispersive readout technique cannot be used to resolve the quantum states of the spin. Here we propose an improved dispersive readout method to measure the quantum states of a weakly coupled qubit by harnessing either one or two auxiliary cavities linearly coupled to the passive cavity containing the qubit. With appropriate parameters in both cases, the system excluding the qubit can exhibit a parity-time-symmetric phase transition at the exceptional point (EP). Because the EP can amplify the perturbation induced by the qubit and the parity-time symmetry can narrow the linewidths of the peaks in the transmission spectrum of the passive cavity, we can measure the quantum states of the weakly coupled qubit via this transmission spectrum. Owing to the weak coupling between the qubit and the passive cavity, the backaction due to the measurement of the qubit can also be reduced in comparison with the conventional dispersive readout technique in the strong-coupling regime.
description: 8 pages, 4 figures
First-in-human study on tolerability, pharmacokinetics and pharmacodynamics of single and multiple escalating doses of XKH001, a recombinant humanized monoclonal antibody against IL-25 in healthy Chinese volunteers
Creators: name: Zhang, Hong
name: Zheng, Wenbo
name: Peng, Ran
name: Wu, Dandan
name: Hu, Yue
name: Sun, Tiantian
name: Gao, Lei
name: Liu, Yusi
name: Guo, Li
name: Ding, Yanhua
name: Liu, Li
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Mental Health

description: XKH001 is a recombinant humanized IgG1 monoclonal antibody against IL-25 for the treatment of type 2 inflammatory diseases. This study aimed to evaluate the tolerability, pharmacokinetics, and pharmacodynamics of XKH001 in humans for the first time. This clinical investigation adopted a randomized, double-blind, and placebo-controlled single ascending dose (SAD) and multiple ascending dose (MAD) design. XKH001 was well tolerated in healthy Chinese subjects. Following repeated administration, XKH001 showed a slow absorption with a median Tmax of 4–7 days and a mean half-life (t1/2) of 22–25 days. The accumulation ratio ranged from 1.34 to 1.99. The exposure was mostly dose proportional, with a mean slope of 0.85–1.06. All subjects tested negative for ADA (except three subjects tested positive). The subjects who received 600 mg XKH001 in the MAD study showed a 78.2 ng/mL decrease in the total immunoglobulin E (IgE) level 85 days after the first administration, while the subjects who received matched placebo exhibited only an 8.6 ng/mL decrease. XKH001 showed favorable safety and pharmacokinetics profiles and a low immunogenicity in its first-in-human study. The data support its further clinical evaluation in patients with type 2 inflammatory diseases. The study was registered in ClinicalTrials.gov (NCT05991661).
Recovery of logged forest fragments in a human-modified tropical landscape during the 2015-16 El Niño
Creators: name: Nunes, Matheus Henrique
name: Jucker, Tommaso
name: Riutta, Terhi
name: Svátek, Martin
name: Kvasnica, Jakub
name: Rejžek, Martin
name: Matula, Radim
name: Majalap, Noreen
name: Ewers, Robert M.
name: Swinfield, Tom
name: Valbuena, Rubén
name: Vaughn, Nicholas R.
name: Asner, Gregory P.
name: Coomes, David A.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Article
/704/158/2165
/704/158/1145
/134
/141
article

description: Funder: Helsingin Yliopisto (University of Helsinki); doi: https://doi.org/10.13039/100007797; Grant(s): profit center: H5101; WBS-number: 75101002
description: Abstract: The past 40 years in Southeast Asia have seen about 50% of lowland rainforests converted to oil palm and other plantations, and much of the remaining forest heavily logged. Little is known about how fragmentation influences recovery and whether climate change will hamper restoration. Here, we use repeat airborne LiDAR surveys spanning the hot and dry 2015-16 El Niño Southern Oscillation event to measure canopy height growth across 3,300 ha of regenerating tropical forests spanning a logging intensity gradient in Malaysian Borneo. We show that the drought led to increased leaf shedding and branch fall. Short forest, regenerating after heavy logging, continued to grow despite higher evaporative demand, except when it was located close to oil palm plantations. Edge effects from the plantations extended over 300 metres into the forests. Forest growth on hilltops and slopes was particularly impacted by the combination of fragmentation and drought, but even riparian forests located within 40 m of oil palm plantations lost canopy height during the drought. Our results suggest that small patches of logged forest within plantation landscapes will be slow to recover, particularly as ENSO events are becoming more frequent.
Winds of Change:A Rapid Appraisal of Four Pulse Value Chains in Myanmar
Creators: name: Haggblade, Steven
name: Boughton, Duncan
name: Kham, L Seng
name: Thaung, Myo
name: Haggblade, Steven
name: Boughton, Duncan
name: Kham, L Seng
name: Thaung, Myo
Publisher: name: Unknown
Year: 2014
Subjects: Food Security and Poverty

description: Pulse exports from Myanmar have grown into a $1 billion export industry in the 25 years since liberalization (Table 1). As the first major agricultural sector to be liberalized, in 1988, pulses offered uniquely attractive returns to both farmers and traders. Farmers and traders responded with alacrity to these new opportunities, propelling pulse production and exports rapidly upwards for several decades (Figure 1).
Invariant measures for stochastic damped 2D Euler equations
Creators: name: Bessaih, Hakima
name: Ferrario, Benedetta
Publisher: name: arXiv
Year: 2019
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60H15, 37L40, 47D07, 76B03, 60J99

description: We study the two-dimensional Euler equations, damped by a linear term and driven by an additive noise. The existence of weak solutions has already been studied; pathwise uniqueness is known for solutions that have vorticity in $L^\infty$. In this paper, we prove the Markov property and then the existence of an invariant measure in the space $L^\infty$ by means of a Krylov-Bogoliubov's type method, working with the weak$\star$ and the bounded weak$\star$ topologies in $L^\infty$.
description: 22 pages. This is the version accepted for publication in Commun. Math. Phys
Apparent nosocomial adaptation of Enterococcus faecalis predates the modern hospital era
Creators: name: Pöntinen, Anna K.
name: Top, Janetta
name: Arredondo-Alonso, Sergio
name: Tonkin-Hill, Gerry
name: Freitas, Ana R.
name: Novais, Carla
name: Gladstone, Rebecca A.
name: Pesonen, Maiju
name: Meneses, Rodrigo
name: Pesonen, Henri
name: Lees, John A.
name: Jamrozy, Dorota
name: Bentley, Stephen D.
name: Lanza, Val F.
name: Torres, Carmen
name: Peixe, Luisa
name: Coque, Teresa M.
name: Parkhill, Julian
name: Schürch, Anita C.
name: Willems, Rob J. L.
name: Corander, Jukka
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Article
/631/181/2474
/631/208/212/748
/631/326/41/2530
/631/326/421
/45/22
/45/23
/45/47
article

description: Funder: the Joint Programming Initiative in Antimicrobial Resistance (JPIAMR2016-AC16/00039)
description: Funder: FCT/MCTES Individual Call to Scientific Employment Stimulus (CEECIND/02268/2017), the Applied Molecular Biosciences Unit - UCIBIO which is financed by national funds from FCT (UIDP/04378/2020 e UIDB/04378/2020)
description: Funder: Trond Mohn Foundation (Grant TMS2019TMT04)
description: Funder: Trond Mohn Foundation (Grant TMS2019TMT04), ERC (Grant 742158)
description: Abstract: Enterococcus faecalis is a commensal and nosocomial pathogen, which is also ubiquitous in animals and insects, representing a classical generalist microorganism. Here, we study E. faecalis isolates ranging from the pre-antibiotic era in 1936 up to 2018, covering a large set of host species including wild birds, mammals, healthy humans, and hospitalised patients. We sequence the bacterial genomes using short- and long-read techniques, and identify multiple extant hospital-associated lineages, with last common ancestors dating back as far as the 19th century. We find a population cohesively connected through homologous recombination, a metabolic flexibility despite a small genome size, and a stable large core genome. Our findings indicate that the apparent hospital adaptations found in hospital-associated E. faecalis lineages likely predate the “modern hospital” era, suggesting selection in another niche, and underlining the generalist nature of this nosocomial pathogen.
Construction of the Vacuum String Field Theory on a non-BPS Brane
Creators: name: Aref'eva, I. Ya.
name: Belov, D. M.
name: Giryavets, A. A.
Publisher: name: arXiv
Year: 2002
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In the framework of the Sen conjectures a construction of vacuum superstring field theory on a non-BPS brane is discussed. A distinguished feature of this theory is a presence of a ghost kinetic operator mixing GSO+/- sectors. A candidate for such kinetic operator with zero cohomology is discussed.
description: expression for the pure ghost kinetic operator corrected, Comments added; 21 pages, 1 figure, LaTeX 2e
Impact Of Livestock Development Programmes On Production & Risk: Case Of The Kaonafatso Ya Dikgomo (KyD) Programme
Creators: name: Ngarava, S.
name: Mushunje, A.
name: Chaminuka, P.
name: Ngarava, S.
name: Mushunje, A.
name: Chaminuka, P.
Publisher: name: Unknown
Year: 2018
Subjects: Livestock Production/Industries

description: Although Livestock Development Programmes (LDPs) increase production, their impact on production risk needs consideration, with most impact assessments in literature devoid of this. The objective of the study was to highlight the risk introduced by participating in a LDP and its impact on productivity. A cross-sectional survey of 164 Kaonafatso ya Dikgomo (KyD) programme and 81 non-programme participants from KwaZulu-Natal, Limpopo and Eastern Cape Provinces, South Africa was utilised. Non-probability convenience sampling was used to collect primary data through a structured questionnaire. Propensity Score Matching and Monte Carlo Simulations were utilised to analyse data. The study found that the KyD programme reduces calving risk by 21.7% whilst it doubles the off-take risk. Furthermore, larger herd sizes, access to veterinary services and frequency of extension contact were risk-increasing determinants, whilst access to dipping services was risk-reducing. The study concludes that the KyD programme has significant impact on production risk. The study recommends that to reduce the risks, farmers should be encouraged to commercialise and become part of farmer organizations. The programme should also maintain a farmer-extension-contact of between 2-5 visits per month as well as target farmers within a 30km-90km radius from a market, with herd sizes of between 50-120 cattle. Key words: calving, off-take, risk, impact, Propensity Score Matching, Monte Carlo Simulation. JEL Codes: O220, Q120, Q160, Q180
On the effective velocity created by a point vortex in two-dimensional hydrodynamics
Creators: name: Chavanis, Pierre-Henri
Publisher: name: arXiv
Year: 2001
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We complete previous investigations on the statistics of velocity fluctuations arising from a random distribution of point vortices in two-dimensional hydrodynamics. We show that, on a statistical sense, the velocity created by a point vortex is shielded by cooperative effects on a distance $Λ\sim n^{-1/2}$, the inter-vortex separation. For $R\gg Λ$, the ``effective'' velocity decays as $R^{-2}$ instead of the ordinary law $R^{-1}$ recovered for $R\ll Λ$. These results are similar to those obtained by Agekyan [Sov. Astron. 5 (1962) 809] in his investigations on the fluctuations of the gravitational field. They give further support to our previous observation that the statistics of velocity fluctuations are (marginally) dominated by the contribution of the nearest neighbor.
description: Submitted to Phys. Rev. E
How do African Farm Households Adapt to Climate Change? A Structural Analysis from Malawi
Creators: name: Sesmero, Juan P.
name: Ricker-Gilbert, Jacob E.
name: Cook, Aaron M.
name: Sesmero, Juan P.
name: Ricker-Gilbert, Jacob E.
name: Cook, Aaron M.
Publisher: name: Unknown
Year: 2015
Subjects: Environmental Economics and Policy
Farm Management
International Development

description: Using three waves of national representative household level panel data from Malawi, we examine two forms of adaptation to climate change: 1) adopting improved maize varieties and 2) adjusting input quantities and income sources. Our results indicate that climate change induces both forms of adaptation, though only the second appears relevant in determining climate change impacts on net revenue. Adverse trends in climate variables (increased temperature and rainfall variability, and reduced growing season rainfall) increase farmers’ reliance on income from subsistence maize production. Assets enhance a household’s capacity for adaptation to climate change by reducing reliance on maize-income.
MOESM1 of Short-term inhibition of glutamine synthetase leads to reprogramming of amino acid and lipid metabolism in roots and leaves of tea plant (Camellia sinensis L.)
Creators: name: Mei-Ya Liu
name: Dandan Tang
name: Yuanzhi Shi
name: Lifeng Ma
name: Li, Yan
name: Qunfeng Zhang
name: Jianyun Ruan
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Plant Biology
subject: 60506 Virology

description: Additional file 1: Table S1. Summary of transcriptome data obtained from tea plants treated with or without methionine (MSX) using Illumina HiSeq.