cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Enhanced Chemiluminescence of a Superior Luminol Derivative Provides Sensitive Smartphone‐Based Point‐of‐Care Testing with Enzymatic μPAD
Creators: name: Rink, Simone
name: Duerkop, Axel
name: Baeumner, Antje J.
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: enzymes · luminescence · paper-based microfluidics · point-of-care testing · sweat analysis
subject: 540 Chemie

description: Chemiluminescence (CL) provides ideal conditions for point-of-care testing (POCT) with wide dynamic ranges, superior sensitivities, and detection simplicity. It has not arrived routinely in the POCT field due to naturally low quantum yields of typical probes and the lack of sensitive low-cost detection devices. Here, we developed a universal microfluidic paper-based analytical device (μPAD) using l-lactate as model analyte. We demonstrate that a smartphone camera can compete with a scientific CCD camera as performance benchmark when using the strong CL emitter, m-carboxy luminol, resulting in extraordinary signal-to-noise ratios of 67. The μPAD provides CV<10 %, stability at room temperature for≥3 months and simple processing. Furthermore, the μPAD enables the detection of picomoles of the luminophore providing additional design flexibility. Thus, this new CL-μPAD is available for translating the many CL standard analytical assays performed in microtiter plates, microarrays or other more complex detection strategies to the POC.
Insights into breast health issues in women's rugby
Creators: name: Wakefield-Scurr, Joanna
name: St John, Edward
name: Bibby, Kilian
name: Renwick, Nichola
name: Smith, Neal
name: Hobbs, Samantha
name: Brown, Nicola
Publisher: name: University of Limerick
Year: 2024
Subjects: classificationCode: 321006
subject: Sport and exercise nutrition

description: World RugbyTM supports dedicated women's welfare, injury surveillance and medical/technical interventions, yet breast health has received limited attention. This article aims to provide insights into breast health issues in rugby, including breast impacts and injuries. We discuss how breast anatomy and position may be problematic in rugby. Breast volume relates to body size, which may be increasing in women's rugby, suggesting increased breast surface area and mass, potentially increasing injury risk. Breast health issues in rugby have been reported previously, with 58% of contact footballers (including rugby) experiencing breast injuries. There are damaging effects related to these breast health issues, with breast impacts often causing pain and swelling. Breast impacts may lead to haematomas, cysts and fat necrosis which can calcify over time making them difficult to distinguish from breast carcinoma, causing further investigation and anxiety. In sport, poor bra fit and insufficient support are associated with pain, skin strain and performance decrements. This article reports the potential implications of these breast health issues on performance in rugby. Recent breast‐related projects supported by rugby communities may address recommendations identified in the literature for robust breast injury classifications, updated injury surveillance systems and prospective data collection on breast injury prevalence, severity and impact in rugby. These data should inform breast injury care pathways and intervention research, including evidence‐based bra design. Understanding the implications of breast impacts on tissue properties, health and wellbeing is vital. Finally, data should inform rugby‐ specific breast education, raising awareness of this aspect of athlete health. Highlights � This article presents published data suggesting breast impacts and injuries are likely to be prevalent in all codes of women's rugby. Player's body mass may be increasing, which is associated with increased breast volume, surface area and mass, which could have an effect on breast injury prevalence in rugby.
Permula lebachensis
Creators: name: NEL, ANDRÉ
name: POSCHMANN, MARKUS J.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Grylloblattodea
Permulidae
Permula
Permula lebachensis

description: Permula lebachensis (Schlechtendal, 1912)
(Fig. 1)
Material. Holotype, Institut für Geowissenschaften der Universität Bonn NVB 50–51 (part and counterpart of the basal fourth of a forewing); new specimen PE2021/5003- LS (a–b, part and counterpart of the basal fourth of a forewing), stored at the Naturhistorisches Museum Mainz/ Landessammlung für Naturkunde Rheinland-Pfalz.
Diagnosis. CuA with three posterior branches; most basal posterior branch of CuA distal to fork of M into its two main branches; a weak arculus (oblique crossvein in area between M and CuA); veinlets in costal area short and weakly oblique (angles between veinlets and main stem of ScP ranging between 30°–50°).
Locality and horizon. Holotype: Steinbach, Lebach- Saar, at the road leading to Sotzweiler/Tholey, Saarland, Germany; Odernheim Subformation, Meisenheim Formation, Lower Rotliegend, probably Asselian–?Sakmarian, early Permian. Specimen PE 2021/5003-LS: Mannweiler-Cölln, Saar-Nahe Basin, Germany; Niedermoschel black shale, Jeckenbach Subformation, Meisenheim Formation, Lower Rotliegend, early Permian.
description: Published as part of NEL, ANDRÉ & POSCHMANN, MARKUS J., 2021, Comparison of the recently described early Permian paoliid genus Permomertovia with the ' eoblattid' genera of the families Permulidae and Permotermopsidae, pp. 39-43 in Palaeoentomology 4 (1) on pages 39-40, DOI: 10.11646/palaeoentomology.4.1.8, http://zenodo.org/record/5507716
Signaling strategies of silver nanoparticles in optical and electrochemical biosensors: considering their potential for the point-of-care
Creators: name: Beck, Franziska
name: Lössl, Michael
name: Baeumner, Antje J.
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: Silver nanoparticles · Optical biosensors · Electrochemical biosensors · Point-of-care · Clinical analysis · Localized surface plasmon resonance
subject: 540 Chemie

description: Silver nanoparticles (AgNPs) have long been overshadowed by gold NPs’ success in sensor and point-of-care (POC) applications. However, their unique physical, (electro)chemical, and optical properties make them excellently suited for such use, as long as their inherent higher instability toward oxidation is controlled. Recent advances in this field provide novel strategies that demonstrate that the AgNPs’ inherent capabilities improve sensor performance and enable the specific detection of analytes at low concentrations. We provide an overview of these advances by focusing on the nanosized Ag (in the range of 1-100 nm) properties with emphasis on optical and electrochemical biosensors. Furthermore, we critically assess their potential for point-of-care sensors discussing advantages as well as limitations for each detection technique. We can conclude that, indeed, strategies using AgNP are ready for sensitive POC applications; however, research focusing on the simplification of assay procedures is direly needed for AgNPs to make the successful jump into actual applications.
Permula simpliciradius NEL & POSCHMANN 2021, comb. nov.
Creators: name: NEL, ANDRÉ
name: POSCHMANN, MARKUS J.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Grylloblattodea
Permulidae
Permula
Permula simpliciradius

description: Permula simpliciradius (Poschmann & Nel, 2020) comb. nov.
Emended diagnosis. CuA with four posterior branches; most basal posterior branch of CuA basal to fork of M into its two main branches; no arculus (oblique crossvein in area between M and CuA); the veinlets in costal area long and oblique (angles between veinlets and main stem of ScP ranging between 20°–30°).
Locality and horizon. Holotype PE 2020/5002- LS a, b (part and counterpart): south of the village of Sitters, Saar-Nahe Basin, Germany; Niedermoschel black shale, Jeckenbach Subformation, Meisenheim Formation, Lower Rotliegend, probably Asselian–?Sakmarian, early Permian. Probably specimen NM 790 (basal fourth of a forewing, private collection of H. Stapf / Nierstein); also from the Niedermoschel black shale, east of the village of Niedermoschel, stored at the Paläontologisches Museum Nierstein, Germany.
description: Published as part of NEL, ANDRÉ & POSCHMANN, MARKUS J., 2021, Comparison of the recently described early Permian paoliid genus Permomertovia with the ' eoblattid' genera of the families Permulidae and Permotermopsidae, pp. 39-43 in Palaeoentomology 4 (1) on page 40, DOI: 10.11646/palaeoentomology.4.1.8, http://zenodo.org/record/5507716
NHC‐Stabilised Parent Tripentelyltrielanes
Creators: name: Szlosek, Robert
name: Weinhart, Michael A. K.
name: Balázs, Gábor
name: Seidl, Michael
name: Zimmermann, Lisa
name: Scheer, Manfred
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: aluminium · gallium · indium · N-heterocyclic carbene · phosphorus
subject: 540 Chemie

description: A missing family of the extremely air sensitive tripentelyltrielanes was discovered. Their stabilisation was achieved by using the bulky NHC IDipp (NHC=N-heterocyclic carbene, IDipp=1,3-bis(2,6-diisopropylphenyl)-imidazolin-2-ylidene). The tripentelylgallanes and tripentelylalanes IDipp ⋅ Ga(PH2)3 (1 a), IDipp ⋅ Ga(AsH2)3 (1 b), IDipp ⋅ Al(PH2)3 (2 a) and IDipp ⋅ Al(AsH2)3 (2 b) were synthesised by salt metathesis of IDipp ⋅ ECl3 (E=Al, Ga, In) with alkali metal pnictogenides such as NaPH2/LiPH2 ⋅ DME and KAsH2, respectively. Moreover, the detection of the first NHC-stabilised tripentelylindiumane IDipp ⋅ In(PH2)3 (3) was possible by multinuclear NMR spectroscopy. Initial investigations of the coordination ability of these compounds resulted in the successful isolation of the coordination compound [IDipp ⋅ Ga(PH2)2(μ3-PH2{HgC6F4}3)] (4) by reaction of 1 a with (HgC6F4)3. The compounds were characterised by multinuclear NMR spectroscopy as well as single crystal X-ray diffraction studies. Supporting computational studies highlight the electronic features of the products.
Investigating nanocatalyst-embedding laser-induced carbon nanofibers for non-enzymatic electrochemical sensing of hydrogen peroxide
Creators: name: Bruckschlegel, Christoph
name: Schlosser, Marc
name: Wongkaew, Nongnoot
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: Hydrogen peroxide detection, Non-enzymatic sensors, Electrochemical detection, Nanocatalysts, Laser-induced carbon nanofibers, Point-of-need devices
subject: 540 Chemie

description: In this present study, we explored the catalytic behaviors of the in situ generated metal nanoparticles, i.e., Pt/Ni, embedded in laser-induced carbon nanofibers (LCNFs) and their potential for H2O2 detection under physiological conditions. Furthermore, we demonstrate current limitations of laser-generated nanocatalyst embedded within LCNFs as electrochemical detectors and possible strategies to overcome the issues. Cyclic voltammetry revealed the distinctive electrocatalytic behaviors of carbon nanofibers embedding Pt and Ni in various ratios. With chronoamperometry at  +0.5 V, it was found that modulation of Pt and Ni content affected only current related to H2O2 but not other interfering electroactive substances, i.e., ascorbic acid (AA), uric acid (UA), dopamine (DA), and glucose. This implies that the interferences react to the carbon nanofibers regardless of the presence of metal nanocatalysts. Carbon nanofibers loaded only with Pt and without Ni performed best in H2O2 detection in phosphate-buffered solution with a limit of detection (LOD) of 1.4 µM, a limit of quantification (LOQ) of 5.7 µM, a linear range from 5 to 500 µM, and a sensitivity of 15 µA mM−1 cm−2. By increasing Pt loading, the interfering signals from UA and DA could be minimized. Furthermore, we found that modification of electrodes with nylon improves the recovery of H2O2 spiked in diluted and undiluted human serum. The study is paving the way for the efficient utilization of laser-generated nanocatalyst-embedding carbon nanomaterials for non-enzymatic sensors, which ultimately will lead to inexpensive point-of-need devices with favorable analytical performance.
In situ Generated Copper(II)‐Quinoline Complexes as Robust and Versatile Photocatalysts for the Chlorosulfonylation of Olefins
Creators: name: Chaibuth, Pawittra
name: Engl, Sebastian
name: Reichle, Alexander
name: Chainok, Kittipong
name: Sukwattanasinitt, Mongkol
name: Reiser, Oliver
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: Chlorosulfonylation; Copper-quinoline complex; Photocatalyst
subject: 540 Chemie

description: A series of copper complexes was synthesized and studied as photocatalysts for the chlorosulfonylation of olefins. Featuring a tetradentate ligand consisting of one amino quinoline and two methyl pyridine moieties, the resulting Cu(II)-complex is effective under visible light irradiation to add sulfonyl chlorides to alkenes and alkynes, including unactivated aliphatic olefins. A weak base additive such as Na2CO3 prevents catalyst poisoning, resulting in an improvement of reaction yields and catalyst lifetime. A broad scope of sulfonyl chlorides and alkenes/alkynes as coupling partners are amenable for the title process, including examples previously reported unsuccessful with established copper-based photocatalysts.
Malacophagomyia
Creators: name: Mulieri, Pablo Ricardo
name: Mello-Patiu, Cátia Antunes
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Sarcophagidae
Malacophagomyia

description: Key to species of Malacophagomyia (males only)
1 Parafacial and fronto-orbital plate with silvery microtomentum (Figs 1–2). Abdomen brown or reddish with gray microtomentum, T5 with lateral spots of silvery-gray microtomentum (Figs 7, 8). Surstylus small, elongated or rounded. Cerci with short
setae or with long villous setae on basal 1/ 2 in dorsal view..................................................... 2 - Parafacial and fronto-orbital plate with golden microtomentum (Fig. 3). Abdomen black with gray microtomentum, T5 with latero-ventral part reddish, with lateral spots of light golden microtomentum (Fig. 22). Surstylus conspicuously large, broad, with rounded tip (Fig. 28). Cerci with long villous setae on basal 3/ 4 in dorsal view (Fig. 27).......... M. rivadavia sp. nov. 2 Syntergosternite 7+8 blackish. Cerci short (cerci length 2X cerci width), covered with short setae (Fig. 12). Arms of ST5 with several fine setae on its inner surface, and short posterior lobes (Fig. 4).................................. M. filamenta
- Syntergosternite 7+8 reddish. Cerci elongated (cerci length 3X cerci width), covered with long villous setae on basal half (Fig. 19). Arms of ST5 with strong spine-like setae on inner surface, and elongated posterior lobes (Fig. 5)......... M. kesselringi
description: Published as part of Mulieri, Pablo Ricardo & Mello-Patiu, Cátia Antunes, 2013, Revision of the Neotropical genus Malacophagomyia (Diptera: Sarcophagidae) with description of a new species, pp. 368-378 in Zootaxa 3736 (4) on pages 370-371, DOI: 10.11646/zootaxa.3736.4.4, http://zenodo.org/record/217356
Soft X-Ray Spectrometers for Absorption Spectroscopy of Aluminum in Laser Driven Backlighter Experiments
Creators: name: Butler, Carlos Esteban
Publisher: name: GSI Helmholtzzentrum fuer Schwerionenforschung, GSI, Darmstadt
Year: 2024

description: Masterarbeit, Technische Universität Darmstadt, 2024; 100 S. (2024). = Masterarbeit, Technische Universität Darmstadt, 2024
Intravenous injection of cyclosporin A loaded lipid nanocapsules fights inflammation and immune system activation in a mouse model of diabetic retinopathy
Creators: name: Bohley, Marilena
name: Dillinger, Andrea E.
name: Braunger, Barbara M.
name: Tamm, Ernst R.
name: Goepferich, Achim
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: Diabetic retinopathy · Intravenous nanotherapy · RPE · Drug delivery · Lipid nanocapsules · Cyclosporin A
subject: 540 Chemie
subject: 570 Biowissenschaften, Biologie
subject: 615 Pharmazie

description: Inflammation and immune system activation are key pathologic events in the onset and escalation of diabetic retinopathy (DR). Both are driven by cytokines and complement originating from the retinal pigment epithelium (RPE). Despite the RPE’s pivotal role, there is no therapeutic tool to specifically interfere with the RPE-related pathomechanism. A therapy that addresses RPE cells and counteracts inflammation and immune response would be of paramount value for the early treatment of DR, where currently are no specific therapies available. Here, we utilized lipoprotein-mimetic lipid nanocapsules to deliver the anti-inflammatory and immunosuppressive drug cyclosporin A (CsA) to RPE cells. Using a mouse model of DR that mirrors all pathologic aspects of human DR, we demonstrate that intravenously applied CsA-loaded lipid nanocapsules comprehensively counteract inflammation and immune system activation. One single injection suppressed the expression of pro-inflammatory cytokines, dampened macrophage infiltration, and prevented macrophage and microglia activation in eyes with DR. This work shows that CsA-loaded lipid nanocapsules can offer new avenues for the treatment of DR.
Brønstedsäure‐Katalyse – Kontrolle der Konkurrenz zwischen monomerem und dimerem Reaktionsweg erhöht Stereoselektivität
Creators: name: Franta, Maximilian
name: Gramüller, Johannes
name: Dullinger, Philipp
name: Kaltenberger, Simon
name: Horinek, Dominik
name: Gschwind, Ruth M.
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: Chiral Phosphoric Acids · Enantioselectivity · Ion Pair Catalysis · NMR · Reaction Mechanism
subject: 540 Chemie

description: Chirale Phosphorsäuren (CPS) sind inzwischen ein bevorzugter Katalysatortyp in der Organokatalyse, jedoch bleibt die Auswahl der optimalen Katalysatorstruktur weiterhin eine Herausforderung. Zusätzlich können unbekannte konkurrierende Reaktionswege die maximale Stereoselektivität und das Potenzial von Vorhersagemodellen einschränken. Bei der CPS-katalysierten Transferhydrierung von Iminen haben wir für viele Systeme zwei Reaktionswege mit inverser Stereoselektivität gefunden, bei denen entweder eine monomere CPS oder ein Wasserstoffbrücken-verknüpftes Dimer als Katalysator fungiert. NMR-Messungen und DFT-Berechnungen offenbarten ein dimeres Intermediat mit einer stärkeren Substrataktivierung durch Kooperativitätseffekte. Beide Wege können separiert werden: Niedrige Temperaturen und hohe Katalysatoranteile begünstigen den dimeren Reaktionsweg (ee bis zu −98 %), während niedrige Temperaturen und reduzierte Katalysatoranteil den monomeren Reaktionsweg fördern und zu einem signifikant verbesserten ee führen (92–99 % ee; vorher 68–86 % bei höheren Temperaturen). Insgesamt wird eine große Auswirkung auf die CPS-Katalyse in Bezug auf Reaktionsoptimierung und Vorhersage erwartet.
A Cyclic Phosphonium Ion with an Asymmetrically Substituted Selenide‐Stabilized Silicon Center: Synthesis, Structure, and Substituent Effects
Creators: name: Fontana, Nicolò
name: Bauer, Jonathan O.
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: Cations·Inorganic rings·Selenium·Silicon·Structure elucidation
subject: 540 Chemie

description: A new heterocyclic four-membered CPSeSi cation was synthesized in its racemic form by B(C6F5)3-mediated ring-closing reaction starting from the hydrosilane precursor. The cation has an asymmetrically substituted silicon center, which is stabilized by a selenium–silicon bond. The phosphonium hydroborate and its precursor were characterized by single-crystal X-ray diffraction analysis and NMR spectroscopy. 77Se, 31P, and 29Si NMR spectroscopic parameters proved to be sensitive probes for determining small electronic changes around the silylium-type center. Density functional theory (DFT) calculations of the ring-opening energy of the selenium-based cation gave insight into the stability of the Se–Si bond and revealed a stronger intramolecular stabilization of the silicon atom compared to a coordinating phosphane sulfide function. For the first time, the influence of a C6F5 group at the silicon atom of these type of cations was also investigated, showing a slightly increased stabilization of the Se–Si linkage in the cyclic selenium-based cation.
Regioselective Rhodium‐Catalyzed 1,2‐Hydroboration of Pyridines and Quinolines Enabled by the Tris(8‐quinolinyl)phosphite Ligand**
Creators: name: Chacón‐Terán, Miguel A.
name: Landaeta, Vanessa R.
name: Wolf, Robert
name: Rodríguez‐Lugo, Rafael E.
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: Chelates · Hydroboration · Phosphites · Reaction mechanisms · Rhodium
subject: 540 Chemie

description: A Rh(I) complex [κ2(P,N)-{P(Oquin)3}RhCl(PPh3)] (1) bearing the P,N ligand tris(8-quinolinyl)phosphite, P(Oquin)3, has been synthesized and structurally characterized. The molecular structure of complex 1 shows that P(Oquin)3 acts as a bidentate P,N chelate ligand. Reactivity studies of 1 reveal that the triphenylphosphine ligand can be replaced by Pcy3 or removed upon oxidation with concomitant coordination of a second 8-quinolyl unit of P(Oquin)3. In addition, the Rh(III) complex [RhCl2{OP(Oquin)2}] (3), resulting from treating 1 with either wet CDCl3 or, sequentially, with HCl and water, was identified by X-ray diffraction analysis. Complex 1 catalyzes the 1,2-regioselective hydroboration of pyridines and quinolines, affording N-boryl-1,2-dihydropyridines (1,2-BDHP) and N-boryl-1,2-hydroquinolines (1,2-BDHQ) in high yield (up to >95 %) with turnover numbers (TONs) of up to 130. The system tolerates a variety of substrates of different electronic and steric nature. In comparison with other transition-metal-based hydroboration catalysts, this system is efficient at a low catalyst loading without the requirement of base or other additives.
Determination of trimetazidine in urine by capillary electrophoresis with amperometric detection
Creators: name: Baroch, Martin
name: Dejmková, Hana
name: Matysik, Frank-Michael
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: Capillary zone electrophoresis · Electrochemistry · Extraction · Trimetazidine
subject: 540 Chemie

description: In this contribution, nonaqueous capillary electrophoresis with end-column amperometric detection using a platinum ultramicroelectrode is presented along with several extraction procedures, both liquid–liquid extraction (LLE) and solid-phase extraction (SPE), for extracting trimetazidine from urine. Trimetazidine is an anti-ischemic drug, which changes hearth metabolism pathways and is being abused as a doping. Electrochemical detection in a nonaqueous environment provided a stable response with a relative standard deviation of only 3.6% (n = 10) in repeatability measurement at concentration of 50 µg cm−3. LOD and LOQ of the proposed method were determined as 0.054 µg cm−3 and 0.180 µg cm−3, respectively. From the point of view of LLE, the most efficient procedure was the double extraction with ethyl acetate as an extraction agent in combination with prior alkalinization of the sample by Na2CO3. Nevertheless, the extraction efficiency was only around 68%. The most efficient SPE procedure was based on the combination of HLB cartridge and elution with background electrolyte containing 20% of methanol. Its recovery reached up to 92% and 101% in case of 50 µg cm−3 and 5.0 µg cm−3 of trimetazidine in urine, respectively.
Intelligibility Enhancement Assessment and Intervention: a single-case experimental design with two multilingual university students
Creators: name: Blake, Helen L.
name: McLeod, Sharynne
name: Verdon, Sarah
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Medicine
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Speech-language pathologists (SLPs) may be approached by multilingual speakers wishing to improve their intelligibility in English. Intelligibility is an essential element of spoken language proficiency and is particularly important for multilingual international students given their need to express complex ideas in an additional language. Intelligibility Enhancement aims to improve the intelligibility and acceptability of consonants, vowels and prosody with multilingual speakers who are learning to speak English. This study aimed to describe the Intelligibility Enhancement Assessment and Intervention Protocols and determine whether the intervention changed multilingual university students’ English intelligibility. A multiple-baseline single-case experimental design was applied with direct inter-subject replication across two female participants whose home languages were Vietnamese and Putonghua (Mandarin). English intelligibility was assessed at multiple intervals pre, post and during intervention. The intervention protocol consisted of 11 weekly 1-h sessions with an SLP targeting English consonants, vowels and prosody. Following intervention, both participants displayed increased performance across most measures. For example, the Vietnamese participant’s percentage of consonants correct (PCC) increased from 62.5% to 85.0% in probe keywords. Effect sizes, when comparing baseline and withdrawal phases, were 5.5 for PCC, 4.6 for final consonants, 2.3 for consonant clusters and 1.6 for syllables indicating improvements in all variables measured. Her speech rate reduced, word stress increased in accuracy and she perceived less difficulty communicating in English. These promising results suggest further testing of the Intelligibility Enhancement Protocols is warranted to determine effectiveness as an intervention for multilingual speakers.
Nukleophiler Angriff am Pentaarsaferrocen [Cp*Fe(η5‐As5)] – Der Weg zu größeren Polyarsenid‐Liganden
Creators: name: Reichl, Stephan
name: Riesinger, Christoph
name: Scheer, Manfred
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: Eisen · Funktionalisierung · Nukleophile · Polyarsenideinheiten · Arsen
subject: 540 Chemie

description: Durch die Reaktion von [Cp*Fe(η5-As5)] (I) (Cp*=C5Me5) mit Hauptgruppenelement-Nukleophilen werden einzigartige funktionalisierte Produkte mit η4-koordinierten Polyarsenid-(Asn)-Einheiten (n=5, 6, 20) erhalten. Mit kohlenstoffbasierten Nukleophilen wie beispielsweise MeLi oder KBn (Bn=CH2Ph) sind die anionischen organo-substituierten Polyarsenidkomplexe [Li(2.2.2-Kryptand)][Cp*Fe(η4-As5Me)] (1 a) und [K(2.2.2-Kryptand)][Cp*Fe{η4-As5(CH2Ph)}] (1 b) zugänglich. Die Verwendung von KAsPh2 führt zu einer selektiven und kontrollierten Erweiterung der As5-Einheit und unter Bildung der monoanionischen Verbindung [K(2.2.2-Kryptand][Cp*Fe(η4-As6Ph2)] (2). Wird I mit [M]As(SiMe3)2 (M=Li ⋅ THF; K) zur Reaktion gebracht, kommt es zur Bildung der größten bekannten anionischen Polyarsenid-Einheit in [M′(2.2.2-Kryptand)]2[(Cp*Fe)4{μ5-η4:η4:η3:η3:η1:η1-As20}] (3)(M′=Li (3 a), K (3 b)).
Chelifer Geoffroy 1762
Creators: name: Judson, Mark L. I.
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Pseudoscorpiones
Cheliferidae
Chelifer

description: Synonymy between Chelifer Geoffroy, 1762 and Obisium Illiger, 1792
Illiger (in Kugelann & Illiger 1798, p. 501) proposed the new generic name Obisium for Acarus cancroides Linnaeus, 1758 (as Scorpio cancroides (Linnaeus, 1758)) and Scorpio cimicoides Fabricius, 1793. No diagnosis was provided, but the inclusion of these two species is a sufficient indication to make Obisium Illiger, 1798 an available name (Article 12.2.5). Illiger (1807, p. 221) later explained that the spelling “ Obisium ” was an error for Opisium and that this name had been proposed as a replacement for Chelifer Geoffroy, 1762:
“Nomen genericum Chelifer minus aptum, quoniam adiectuum est, cum nomine Opisium commutaui, quod incessui retrogrado horum insectorum alludit. Obisium, quod cel Latreille scripsit, erroneum est, nomen enim ab οπισω, retro, deduxi.” [Because the generic name Chelifer is less suitable, being an adjective, it was changed to Opisium, which alludes to the retrograde gait of these insects. Obisium, as Latreille wrote it, is erroneous, the name being derived from οπισω, backwards.]
There is no internal evidence of this error in Kugelann & Illiger (1798); examination of the typography shows that Obisium is indeed written with a ‘b’ rather than an inverted ‘p’. Opisium Illiger, 1807 is therefore an unjustified emendation of Obisium Illiger, 1798 and its junior objective synonym (Article 33.2.3). It is not clear why Illiger (1807) only referred to Latreille’s (1804a) use of ‘ Obisium ’, but perhaps he had not noticed that Opisium was misprinted in his own work. Illiger’s (1807) correction has generally been overlooked or ignored by subsequent authors, except Kew (1911). Obisium Illiger, 1798 was placed on the Official List of Rejected and Invalid Names in Zoology by Opinion 1542 (International Commission on Zoological Nomenclature 1989), as a junior objective synonym of the conserved name Chelifer Geoffroy, 1762. Illiger (1798) did not indicate a type species for Obisium and, because he did not mention Chelifer in that work, the provisions of article 67.8 of the Code (concerning type species of nominal genus-group taxa denoted by new replacement names) do not apply. The first valid designation of a type species appears to be that of Westwood (1836), who stated that Acarus cancroides was the type species of both Obisium and Chelifer. Harvey (1991) considered that Chamberlin (1930) had been responsible for designating A. cancroides as the type of Obisium Illiger, 1798, but Chamberlin simply stated (erroneously) that this was the only species included in Obisium by Illiger (1798).
description: Published as part of Judson, Mark L. I., 2012, Nomenclatural problems associated with the generic names Obisium Leach, 1814, Blothrus Schiödte, 1847 and Neobisium Chamberlin, 1930 (Arachnida: Chelonethi), pp. 21-35 in Zootaxa 3475 on page 22, DOI: 10.5281/zenodo.210910
Stereochemically Pure Si‐Chiral Aminochlorosilanes
Creators: name: Kümper, Manuel
name: Götz, Tobias
name: Espinosa‐Jalapa, Noel Angel
name: Falk, Alexander
name: Rothfelder, Robin
name: Bauer, Jonathan O.
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: Aminochlorosilanes· Chirality·Interaction patterns· Silanols · Silicon
subject: 540 Chemie

description: Silicon-based compounds with stereochemical information and convertible functional units are valuable building blocks in synthetic chemistry. Si-stereogenic aminochlorosilanes are built up by Si−N bond formation between an achiral dichlorosilane and a chiral enantiomerically pure primary amine. Both diastereomers could be isolated as stereochemically pure single-crystals by fractional crystallization and were analyzed by X-ray crystallography. Defined intermolecular interaction patterns were identified illustrating the role of N−H⋅⋅⋅π, C−H⋅⋅⋅π, and N−H⋅⋅⋅Cl contacts in the molecular crystalline packing arrangements. Stepwise functionalization of the silicon−chlorine and silicon−amine functions was carried out, demonstrating their potential for use as a chiral synthesis precursors. Via optically pure aminomethoxysilanes, enantiomerically enriched methoxysilanols, chloromethoxysilanes, and methoxysilanethiols were synthesized. The stereospecificity of the transformations was monitored. The (R)-BINOL-PSSLi method for determining the enantiomeric purity was found to be the tool of choice for acid-sensitive silanols and silanethiols.
Chthonius C.L. Koch 1843
Creators: name: Judson, Mark L. I.
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Pseudoscorpiones
Chthoniidae
Chthonius

description: Synonymy between Chthonius C.L. Koch, 1843 and Obisium Leach, 1814
The genus Chthonius C.L. Koch, 1843 was created for Chelifer trombidioides Latreille, 1804 and Obisium orthodactylum Leach, 1817, which Koch (1843) treated as separate species, even though they are objective synonyms (Judson 1997). The type species of Chthonius was later designated as O. orthodactylum by Simon (1879), who also overlooked this synonymy. Chthonius is thus a junior objective synonym of Obisium Leach, 1814, but remains the valid name of the genus because Obisium Leach, 1814 is a junior homonym of Obisium Illiger, 1798.
description: Published as part of Judson, Mark L. I., 2012, Nomenclatural problems associated with the generic names Obisium Leach, 1814, Blothrus Schiödte, 1847 and Neobisium Chamberlin, 1930 (Arachnida: Chelonethi), pp. 21-35 in Zootaxa 3475 on page 25, DOI: 10.5281/zenodo.210910
Bilayer‐Coating Strategy for Hydrophobic Nanoparticles Providing Colloidal Stability, Functionality, and Surface Protection in Biological Media
Creators: name: Schroter, Alexandra
name: Arnau del Valle, Carla
name: Marín, María J.
name: Hirsch, Thomas
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: Fluorescent Probe · Interfaces · Lanthanides · Nanoparticles · Surface Chemistry
subject: 540 Chemie

description: The surface chemistry of nanoparticles is a key step on the pathway from particle design towards applications in biologically relevant environments. Here, a bilayer-based strategy for the surface modification of hydrophobic nanoparticles is introduced that leads to excellent colloidal stability in aqueous environments and good protection against disintegration, while permitting surface functionalization via simple carbodiimide chemistry. We have demonstrated the excellent potential of this strategy using upconversion nanoparticles (UCNPs), initially coated with oleate and therefore dispersible only in organic solvents. The hydrophobic oleate capping is maintained and a bilayer is formed upon addition of excess oleate. The bilayer approach renders protection towards luminescence loss by water quenching, while the incorporation of additional molecules containing amino functions yields colloidal stability and facilitates the introduction of functionality. The biological relevance of the approach was confirmed with the use of two model dyes, a photosensitizer and a nitric oxide (NO) probe that, when attached to the surface of the UCNPs, retained their functionality to produce singlet oxygen and detect intracellular NO, respectively. We present a simple and fast strategy to protect and functionalize inorganic nanoparticles in biological media, which is important for controlled surface engineering of nanosized materials for theranostic applications.
Formation of a Hexaphosphido Cobalt Complex through P−P Condensation
Creators: name: Hoidn, Christian M.
name: Trabitsch, Karolina
name: Schwedtmann, Kai
name: Taube, Clemens
name: Weigand, Jan J.
name: Wolf, Robert
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: cobalt · polyphosphorus compounds · P-P condensation · phosphorus
subject: 540 Chemie

description: The reaction between diphosphorus derivatives [(ClImDipp)P2(Dipp)]OTf (1[OTf]) and [(ClImDipp)P2(Dipp)Cl] (1[Cl]) with the cyclotetraphosphido cobalt complex [K(18c-6)][(PHDI)Co(η4-cyclo-P4)] (2) leads to the formation of complex [(PHDI)Co{η4-cyclo-P6(Dipp)(ClImDipp)}] (3), which features an unusual hexaphosphido ligand [ClImDipp=4,5-dichloro-1,3-bis(2,6-diisopropylphenyl)imidazol-2-yl, Dipp=2,6-diisopropylphenyl, 18c-6=18-crown-6, PHDI=bis(2,6-diisopropylphenyl)phenanthrene-9,10-diimine]. Complex 3 was obtained as a crystalline material with a moderate yield at low temperature. Upon exposure to ambient temperature, compound 3 slowly transforms into two other compounds, [K(18c-6)][(PHDI)Co(η4-P7Dipp)] (4) and [(PHDI)Co{cyclo-P5(ClImDipp)}] (5). The novel complexes 3–5 were characterized using multinuclear NMR spectroscopy and single-crystal X-ray diffraction. To shed light on the formation of these compounds, a proposed mechanism based on 31P NMR monitoring studies is presented.
The Role of Conjugation in the Halogen−Lithium Exchange Selectivity: Lithiation of 4,6,7,9‐Tetrabromo‐1,3‐dimethyl‐2,3‐dihydro‐1H‐perimidine
Creators: name: Yakubenko, Artyom A.
name: Tupikina, Elena Yu.
name: Antonov, Alexander S.
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: organolithiums · conjugation · coordination · regioselectivity · naphthalene
subject: 540 Chemie

description: The first case of successful suppression of the coordination of a lithium atom with a dialkylamino group by the effective conjugation of the latter with the aromatic core has been discovered. This effect controls regioselectivity of the bromine−lithium exchange in 4,6,7,9-tetrabromo-1,3-dimethyl-2,3-dihydro-1H-perimidine, which leads to products with the most effective conjugation. As a result, the product of this quadruple exchange demonstrates no tendency of the coordination of the NMe groups to neighboring lithium atoms despite the absence of steric restrictions. Experimental results are explained by means of quantum chemical calculations: geometry optimization, natural bond analysis and scans using the modredundant scheme.
Titanium‐Catalyzed Polymerization of a Lewis Base‐Stabilized Phosphinoborane
Creators: name: Braese, Jens
name: Lehnfeld, Felix
name: Annibale, Vincent T.
name: Oswald, Tim
name: Beckhaus, Rüdiger
name: Manners, Ian
name: Scheer, Manfred
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: inorganic polymers · phosphorus · boron · polymerization reaction · titanium
subject: 540 Chemie

description: The reaction of the Lewis base-stabilized phosphinoborane monomer tBuHPBH2NMe3 (2 a) with catalytic amounts of bis(η5:η1-adamantylidenepentafulvene)titanium (1) provides a convenient new route to the polyphosphinoborane [tBuPH-BH2]n (3 a). This method offers access to high molar mass materials under mild conditions and with short reaction times (20 °C, 1 h in toluene). It represents an unprecedented example of a transition metal-mediated polymerization of a Lewis base-stabilized Group 13/15 compound. Preliminary studies of the substrate scope and a potential mechanism are reported.
Study of the response characteristics of an online electrochemical mass spectrometry system for gas analysis of lithium-ion cells using chronoamperometry
Creators: name: Scharf, Janik
name: Matysik, Frank-Michael
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: Electrochemistry · Lithium-ion cell · Mass spectrometry · Material science · Gas analysis · Response time
subject: 540 Chemie

description: Online electrochemical mass spectrometry (OEMS) is a promising analytical technique to monitor minor side reactions with gaseous species, taking place while charging and discharging a lithium-ion cell. However, besides the manifold examples of these custom-made systems and their application, a clear analytical view on the origin of the evolving gasses and their manifold interactions within the cell environment is missing and therefore given in this work. To get a better understanding of the complexity of gas evolution associated with electrochemical reactions in lithium-ion cells, the use of chronoamperometry as an analytical method was chosen. This led to a precise variation of the applied voltage and voltage-pulse length and enabled therewith a clear starting point of the electrochemically triggered reactions. It was found that chronoamperometry can be used to precisely trigger those reactions with gaseous products. Additionally, it was found that the release of gaseous species depends on many parameters including the cell configuration, the current, and the gas species. The response time determination showed that a custom-made highly porous electrode configuration had an overall better response behavior within minutes with differences for the respective gasses of interest, compared to a standard foil configuration cells. The herein presented methodology shows how an electroanalytical approach can help gain further insight into advanced hyphenated methods, such as OEMS in the context of studies of lithium-ion cells.
Synthesis of β-phosphonomalonates using a recyclable choline hydroxide catalyst
Creators: name: Kalla, Reddi Mohan Naidu
name: Varalakshmi, M.
name: Raju, C.
name: Lee, Jaewoong
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Plant Biology
subject: FOS: Biological sciences

description: Choline hydroxide (ChOH) is an effective ionic liquid (IL) that enables the straightforward construction of β-phosphonomalonates in basic medium. A variety of compounds, including aromatic/heterocyclic and aliphatic aldehydes (1a–p) were reacted with dicyanomethane (2) and diethyl phosphonate (3) to produce the targeted products in good yields (4a–p). The constructed compounds as well as the IL were characterized using spectral 1H, 13C, and 31P NMR.
Catalyst- and chromatography-free multi-component domino synthesis of 5-alkyl barbituric acids at room temperature
Creators: name: Baruah, Biswajita
name: Sarma, Monoj
name: Rastogi, Gaurav K.
name: Deb, Mohit L.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Cell Biology
Biotechnology
Chemical Sciences not elsewhere classified
Mental Health

description: 5-Alkylated barbituric acids are an important class of compounds that constitute the basic moiety of several clinically used hypnotic drugs. Here we report a catalyst-free domino Knoevenagel-Michael addition involving barbituric acid, aldehyde, and N,N-disubstituted aniline in solvent acetonitrile to synthesize 5-alkylated barbituric acid derivatives (72–94% yield) without using any chromatographic separation techniques. The C-4 position of aniline acts as the Michael donor. All the reactions are successfully performed without catalysts, providing an environment-friendly and economical route for the synthesis. Moreover, catalyst-free reactions are less sensitive to air and moisture unlike many metal catalysts, with easy separation of products, and simple operating procedures as there is no need for catalyst weighing, recovery, and removal. A plausible mechanism is also proposed based on control experiments.
Synthesis of aromatic aldehydes via silver(I)-catalyzed formylation of aryl bromides in DMF promoted by samarium metal in air
Creators: name: Li, Aowen
name: Chen, Hongping
name: Mi, Mingzhong
name: Wang, Chao
name: Qi, Yan
name: Liu, Yongjun
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Molecular Biology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Computational Biology

description: Under ambient temperature conditions, a novel method has been developed for the conversion of aryl bromides to aromatic aldehydes, utilizing DMF (N,N-dimethylformamide) as both the starting material and solvent, in the presence of samarium metal and a trace of silver salts. This research has successfully explored an efficient approach for Barbier-type addition reactions, leading to the establishment of a novel C-C bond. A variety of bromides have been investigated as substrates, and aldehydes are readily obtained in moderate to high yields under mild conditions. The presence of 1 mol% of silver nitrate and potassium iodide is sufficient to catalyze the reaction, with the primary role of potassium iodide being to generate soluble silver iodide in the organic solvent, thereby catalyzing the reaction. The mechanism of the silver(I)-catalyzed process is discussed.
Novel synthesis of a new class of substituted S-glycosylisothiourea derivatives and their conversion to 5-amino-1,2,4-triazoles
Creators: name: Abu-Zaied, Mamdouh A.
name: Nawwar, Galal A.
name: Elgemeie, Galal H.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: The one-pot reaction of potassium cyanocarbamimidothiolates with acetylated bromo sugars produced a novel class of substituted glycosylisothiourea derivatives 5a–h that demonstrated their Z-configuration. Some of the later compounds 5a–d were treated with NH3 in methanol at 25 °C, to afford the unprotected thioglycoside functionalized compounds 6a–c with excellent yields. To characterize the structure of the newly synthesized compounds, various techniques, such as elemental analysis and spectral data (13C NMR, IR, and 1H NMR) were employed. Furthermore, the substituted S-glycosylisothioureas 5 and 6 were subjected to a reaction with hydrazine hydrate, resulting in the formation of corresponding 5-amino-1,2,4-triazole derivatives 7a–d. The antibacterial properties of all newly synthesized compounds were thoroughly assessed and evaluated. Among these compounds, the most potent antimicrobial agents were found to be compounds 5a, 5g, 6a, 6b, and 6c.
Copidognathus Trouessart
Creators: name: Chatterjee, Tapas
name: Marshall, David J
name: Pešić, Vladimir
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Halacaridae
Copidognathus

description: Genus Copidognathus Trouessart
Diagnosis: Palps four-segmented, attached laterally, P2 with one distal seta, P3 without a seta, P4 with three setae in basal whorl. Female GA with usually three pairs (rarely up to five pairs) of PGS and one pair of SGS. Genua shorter than tibiae and telofemora. Tibia I with three ventral setae. Tibia II generally with three ventral setae. Tarsi I and II with dorsolateral solenidion. Paired lateral claws, small median claw. Only one nymphal stage (the protonymph) present.
description: Published as part of Chatterjee, Tapas, Marshall, David J & Pešić, Vladimir, 2012, New records of Copidognathus mites (Acari: Halacaridae) from mangroves in Brunei Darussalam with descriptions of two new species, pp. 18-30 in Zootaxa 3269 on page 19, DOI: 10.5281/zenodo.210913
Tetrabutylammonium hydroxide (TBAH) ionic liquid for the sustainable and efficient production of α-hydroxyphosphonates
Creators: name: Kalla, Reddi Mohan Naidu
name: Lee, Jaewoong
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Ionic liquids were known as eco-solvents/catalysts, encourages the clean hydrophosphonylation of aldehydes to produce structurally various α-hydroxyphosphonates in a well-organized and ecologically friendly manner. This study used tetrabutylammonium hydroxide (TBAH) used to addition phosphite nucleophiles to aldehydes under neat condition, resulting in different α-hydroxyphosphonates that are essential components of the modern chemical industry. The current method produces targeted compounds from a wide range of aromatic, and heteroaromatic aldehydes with various substitution. The current protocol has high impact because it allows for the formation of desired products in good yields. This catalyst is applicable for gram scale synthesis of the targeted product and without any additional energy (Microwave, ultrasonication, ball milling and thermal heating). Some reported methods used various external sources (mechano-chemical) for the synthesis of α-hydroxyphosphonates.