Dynamic Contrast-Enhanced MRI of Prostate Lesions of Simultaneous [68Ga]Ga-PSMA-11 PET/MRI: Comparison between Intraprostatic Lesions and Correlation between Perfusion Parameters
Creators: name: Zhao, Jing
name: Kader, Avan
name: Mangarova, Dilyana B.
name: Brangsch, Julia
name: Brenner, Winfried
name: Hamm, Bernd
name: Makowski, Marcus R.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: prostate cancer
subject: PSMA
subject: PET
subject: MRI
subject: dynamic contrast-enhanced
subject: arrival time
subject: time to peak
subject: wash-in slope
subject: wash-out slope
subject: peak enhancement intensity
subject: initial area under curve
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Simple Summary Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is an important method to analyze the perfusion model of tumors, allowing noninvasive quantification of microvascular structure and function. Furthermore, simultaneous [Ga-68]Ga-prostate-specific membrane antigen (PSMA)-11 positron emission tomography (PET)/MRI is currently the most advantageous way for assessing prostate cancer staging. Therefore, combining these two examinations helps to diagnose the lesions more comprehensively. Our study analyzes perfusion parameters between intraprostatic lesions and the correlation between perfusion parameters and [Ga-68]Ga-PSMA-11 PET. This study highlights the significant effect of PSMA uptake on perfusion parameters. Abstract We aimed to retrospectively compare the perfusion parameters measured from dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) of prostate benign lesions and malignant lesions to determine the relationship between perfusion parameters. DCE-MRI was performed in patients with PCa who underwent simultaneous [Ga-68]Ga-prostate-specific membrane antigen (PSMA)-11 positron emission tomography (PET)/MRI. Six perfusion parameters (arrival time (AT), time to peak (TTP), wash-in slope (W-in), wash-out slope (W-out), peak enhancement intensity (PEI), and initial area under the 60-s curve (iAUC)), and a semi-quantitative parameter, standardized uptake values maximum (SUVmax) were calculated by placing regions of interest in the largest area of the lesions. The DCE-MRI parameters between prostate benign and malignant lesions were compared. The DCE-MRI parameters in both the benign and malignant lesions subgroup with SUVmax &lt;= 3.0 and SUVmax &gt; 3.0 were compared. The correlation of DCE-MRI parameters was investigated. Malignant lesions demonstrated significantly shorter TTP and higher SUVmax than did benign lesions. In the benign and malignant lesions subgroup, perfusion parameters of lesions with SUVmax &lt;= 3.0 show no significant difference to those with SUVmax &gt; 3.0. DCE-MRI perfusion parameters show a close correlation with each other. DCE-MRI parameters reflect the perfusion characteristics of intraprostatic lesions with malignant lesions, demonstrating significantly shorter TTP. There is a moderate to strong correlation between DCE-MRI parameters. Semi-quantitative analysis reflects that malignant lesions show a significantly higher SUVmax than benign lesions.