title: ÐÐ»Ð¸ÑÐ½Ð¸Ðµ Ð¿ÑÐµÐ½Ð°ÑÐ°Ð»ÑÐ½Ð¾Ð¹ Ð³Ð¸Ð¿ÐµÑÐ³Ð¾Ð¼Ð¾ÑÐ¸ÑÑÐµÐ¸Ð½ÐµÐ¼Ð¸Ð¸ Ð½Ð° ÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð½ÐµÑÐ²Ð½Ð¾Ð¹ ÑÐºÐ°Ð½Ð¸ ÐºÐ¾ÑÑ Ð¼Ð¾Ð·Ð³Ð° ÐºÑÑÑ Ð² ÑÐ°Ð½Ð½ÐµÐ¼ Ð¾Ð½ÑÐ¾Ð³ÐµÐ½ÐµÐ·Ðµ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Effect of prenatal hyperhomocysteinemia on the formation of neural tissue of rat cerebral cortex in early ontogenesis
Creators: name: ÐÐ¸ÑÐµÐ»Ñ, ÐÐ½Ð°ÑÑÐ°ÑÐ¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: Ð¿ÑÐµÐ½Ð°ÑÐ°Ð»ÑÐ½Ð°Ñ Ð³Ð¸Ð¿ÐµÑÐ³Ð¾Ð¼Ð¾ÑÐ¸ÑÑÐµÐ¸Ð½ÐµÐ¼Ð¸Ñ
ÐºÐ¾ÑÐ° Ð³Ð¾Ð»Ð¾Ð²Ð½Ð¾Ð³Ð¾ Ð¼Ð¾Ð·Ð³Ð°
ÐºÐ°ÑÐ¿Ð°Ð·Ð°-3
Ð³Ð¸Ð±ÐµÐ»Ñ ÐºÐ»ÐµÑÐ¾Ðº
Ð°Ð¿Ð¾Ð¿ÑÐ¾Ð·
Ð°ÐºÑÐ¸Ð²Ð°ÑÐ¸Ñ Ð³Ð»Ð¸Ð¸
Ð½ÐµÐ¹ÑÐ¾Ð²Ð¾ÑÐ¿Ð°Ð»ÐµÐ½Ð¸Ðµ
ÑÐ¸ÑÐ¾ÐºÐ¸Ð½Ñ
prenatal hyperhomocysteinemia
cerebral cortex
caspase-3
cell death
apoptosis
glia activation
neuroinflammation
cytokines

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description: At this work we studied the formation of the cerebral cortex tissue of rat pups, the embryonic development of which occurred under conditions of maternal hyperhomocysteinemia. The following methods were used for the study: fluorescence microscopy to determine the cellular composition of the parietal cortex of rat pups, ELISA for measurement the pro-inflammatory cytokines content, colorimetric method and immunoblot to determine the activity and level of caspase-3. The decrease in the number of neurons, glia activation, an increase in the level of active caspase-3 and its activity, as well as an increase in the content of interleukin-1Î² were shown. The findings suggest homocysteine-induced cell death and the development of neuroinflammation in the cerebral cortex of rats.