cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Folding Wings like a Cockroach: A Review of Transverse Wing Folding Ensign Wasps (Hymenoptera: Evaniidae: Afrevania and Trissevania)
Creators: name: Mikó, István
name: Balhoff, James P.
name: Yoder, Matthew J.
name: Deans, Andrew R.
name: Copeland, Robert S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: We revise two relatively rare ensign wasp genera, whose species are restricted to Sub-Saharan Africa: Afrevania and Trissevania. Afrevania longipetiolata sp. nov., Trissevania heatherae sp. nov., T. hugoi sp. nov., T. mrimaensis sp. nov. and T. slideri sp. nov. are described, males and females of T. anemotis and Afrevania leroyi are redescribed, and an identification key for Trissevaniini is provided. We argue that Trissevania mrimaensis sp. nov. and T. heatherae sp. nov. populations are vulnerable, given their limited distributions and threats from mining activities in Kenya. We hypothesize that these taxa together comprise a monophyletic lineage, Trissevaniini, tr. nov., the members of which share the ability to fold their fore wings along two intersecting fold lines. Although wing folding of this type has been described for the hind wing of some insects four-plane wing folding of the fore wing has never been documented. The wing folding mechanism and the pattern of wing folds of Trissevaniini is shared only with some cockroach species (Blattodea). It is an interesting coincidence that all evaniids are predators of cockroach eggs. The major wing fold lines of Trissevaniini likely are not homologous to any known longitudinal anatomical structures on the wings of other Evaniidae. Members of the new tribe share the presence of a coupling mechanism between the fore wing and the mesosoma that is composed of a setal patch on the mesosoma and the retinaculum of the fore wing. While the setal patch is an evolutionary novelty, the retinaculum, which originally evolved to facilitate fore and hind wing coupling in Hymenoptera, exemplifies morphological exaptation. We also refine and clarify the Semantic Phenotype approach used in previous taxonomic revisions and explore the consequences of merging new with existing data. The way that semantic statements are formulated can evolve in parallel, alongside improvements to the ontologies themselves.
Algebraic synthesis of time-optimal unitaries in SU(2) with alternating controls
Creators: name: Aiello, Clarice D.
name: Allegra, Michele
name: Hemmerling, Boerge
name: Wang, Xiaoting
name: Cappellaro, Paola
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present an algebraic framework to study the time-optimal synthesis of arbitrary unitaries in SU(2), when the control set is restricted to rotations around two non-parallel axes in the Bloch sphere. Our method bypasses commonly used control-theoretical techniques, and easily imposes necessary conditions on time-optimal sequences. In a straightforward fashion, we prove that time-optimal sequences are solely parametrized by three rotation angles and derive general bounds on those angles as a function of the relative rotation speed of each control and the angle between the axes. Results are substantially different whether both clockwise and counterclockwise rotations about the given axes are allowed, or only clockwise rotations. In the first case, we prove that any finite time-optimal sequence is composed at most of five control concatenations, while for the more restrictive case, we present scaling laws on the maximum length of any finite time-optimal sequence. The bounds we find for both cases are stricter than previously published ones and severely constrain the structure of time-optimal sequences, allowing for an efficient numerical search of the time-optimal solution. Our results can be used to find the time-optimal evolution of qubit systems under the action of the considered control set, and thus potentially increase the number of realizable unitaries before decoherence.
MIGNEX Case Study Brief TUR3 - Migration and development dynamics in Kilis, Turkey
Creators: name: Ensari, Pınar
name: Kavur, Nilay
name: Hannah, Murray
Publisher: name: Peace Research Institute Oslo
Year: 2022

description: Mass emigration to Kilis during the Syrian civil war led to rapid spatial, cultural, and demographic transformation. Despite humanitarian interventions, Kilis faces challenges in infrastructure and social cohesion.

Key Takeaways

The increased population and the closing of the Turkey–Syria border brought about major transformation for Kilis, including infrastructure and social protection reform.

There is a pervasive perception of abandonment by the state, and many feel there are limited opportunities for them in Kilis.

Just under half (46%) of surveyed young adults grew up in Kilis. Of the Syrian respondents, 30% grew up elsewhere in Turkey; 62% grew up in another country - mostly Syria (98%)
Gap Junctional Communication in Osteocytes Is Amplified by Low Intensity Vibrations In Vitro
Creators: name: Thompson, William R.
name: Uzer, Gunes
name: Pongkitwitoon, Suphannee
name: Rubin, Janet
name: Ian, Cheng
name: Judex, Stefan
name: Chan, Meilin E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The physical mechanism by which cells sense high-frequency mechanical signals of small magnitude is unknown. During exposure to vibrations, cell populations within a bone are subjected not only to acceleratory motions but also to fluid shear as a result of fluid-cell interactions. We explored displacements of the cell nucleus during exposure to vibrations with a finite element (FE) model and tested in vitro whether vibrations can affect osteocyte communication independent of fluid shear. Osteocyte like MLO-Y4 cells were subjected to vibrations at acceleration magnitudes of 0.15 g and 1 g and frequencies of 30 Hz and 100 Hz. Gap junctional intracellular communication (GJIC) in response to these four individual vibration regimes was investigated. The FE model demonstrated that vibration induced dynamic accelerations caused larger relative nuclear displacement than fluid shear. Across the four regimes, vibrations significantly increased GJIC between osteocytes by 25%. Enhanced GJIC was independent of vibration induced fluid shear; there were no differences in GJIC between the four different vibration regimes even though differences in fluid shear generated by the four regimes varied 23-fold. Vibration induced increases in GJIC were not associated with altered connexin 43 (Cx43) mRNA or protein levels, but were dependent on Akt activation. Combined, the in silico and in vitro experiments suggest that externally applied vibrations caused nuclear motions and that large differences in fluid shear did not influence nuclear motion (<1%) or GJIC, perhaps indicating that vibration induced nuclear motions may directly increase GJIC. Whether the increase in GJIC is instrumental in modulating anabolic and anti-catabolic processes associated with the application of vibrations remains to be determined.
Gastroesophageal Reflux in Relation to Adenocarcinomas of the Esophagus: A Pooled Analysis from the Barrett’s and Esophageal Adenocarcinoma Consortium (BEACON)
Creators: name: Nyrén, Olof
name: Vaughan, Thomas L.
name: Gammon, Marilie D.
name: Kamangar, Farin
name: Casson, Alan G.
name: Liao, Linda M.
name: Chow, Wong-Ho
name: Cook, Michael B.
name: Freedman, Neal D.
name: Corley, Douglas A.
name: Ye, Weimin
name: Murray, Liam J.
name: Risch, Harvey A.
name: Bernstein, Leslie
name: Wu, Anna H.
name: Pandeya, Nirmala
name: Whiteman, David C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: BackgroundPrevious studies have evidenced an association between gastroesophageal reflux and esophageal adenocarcinoma (EA). It is unknown to what extent these associations vary by population, age, sex, body mass index, and cigarette smoking, or whether duration and frequency of symptoms interact in predicting risk. The Barrett’s and Esophageal Adenocarcinoma Consortium (BEACON) allowed an in-depth assessment of these issues.MethodsDetailed information on heartburn and regurgitation symptoms and covariates were available from five BEACON case-control studies of EA and esophagogastric junction adenocarcinoma (EGJA). We conducted single-study multivariable logistic regressions followed by random-effects meta-analysis. Stratified analyses, meta-regressions, and sensitivity analyses were also conducted.ResultsFive studies provided 1,128 EA cases, 1,229 EGJA cases, and 4,057 controls for analysis. All summary estimates indicated positive, significant associations between heartburn/regurgitation symptoms and EA. Increasing heartburn duration was associated with increasing EA risk; odds ratios were 2.80, 3.85, and 6.24 for symptom durations of <10 years, 10 to <20 years, and ≥20 years. Associations with EGJA were slighter weaker, but still statistically significant for those with the highest exposure. Both frequency and duration of heartburn/regurgitation symptoms were independently associated with higher risk. We observed similar strengths of associations when stratified by age, sex, cigarette smoking, and body mass index.ConclusionsThis analysis indicates that the association between heartburn/regurgitation symptoms and EA is strong, increases with increased duration and/or frequency, and is consistent across major risk factors. Weaker associations for EGJA suggest that this cancer site has a dissimilar pathogenesis or represents a mixed population of patients.
Magnetomechanical response of bilayered magnetic elastomers
Creators: name: Allahyarov, Elshad
name: Menzel, Andreas M.
name: Zhu, Lei
name: Löwen, Hartmut
Publisher: name: arXiv
Year: 2014
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Magnetic elastomers are appealing materials from an application point of view: they combine the mechanical softness and deformability of polymeric substances with the addressability by external magnetic fields. In this way, mechanical deformations can be reversibly induced and elastic moduli can be reversibly adjusted from outside. So far, mainly the behavior of single-component magnetic elastomers and ferrogels has been studied. Here, we go one step further and analyze the magnetoelastic response of a bilayered material composed of two different magnetic elastomers. It turns out that, under appropriate conditions, the bilayered magnetic elastomer can show a strongly amplified deformational response in comparison to a single-component material. Furthermore, a qualitatively opposite response can be obtained, i.e.\ a contraction along the magnetic field direction (as opposed to an elongation in the single-component case). We hope that our results will further stimulate experimental and theoretical investigations directly on bilayered magnetic elastomers, or, in a further hierarchical step, on bilayered units embedded in yet another polymeric matrix.
description: 25 pages, 10 figures
Gatekeepers or Intermediaries? The Role of Clinicians in Commercial Genomic Testing
Creators: name: Juengst, Eric T.
name: Fishman, Jennifer R.
name: Settersten, Richard A.
name: Lambrix, Marcie A.
name: McGowan, Michelle L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: BackgroundMany commentators on “direct-to-consumer” genetic risk information have raised concerns that giving results to individuals with insufficient knowledge and training in genomics may harm consumers, the health care system, and society. In response, several commercial laboratories offering genomic risk profiling have shifted to more traditional “direct-to-provider” (DTP) marketing strategies, repositioning clinicians as the intended recipients of advertising of laboratory services and as gatekeepers to personal genomic information. Increasing popularity of next generation sequencing puts a premium on ensuring that those who are charged with interpreting, translating, communicating and managing commercial genomic risk information are appropriately equipped for the job. To shed light on their gatekeeping role, we conducted a study to assess how and why early clinical users of genomic risk assessment incorporate these tools in their clinical practices and how they interpret genomic information for their patients.Methods and FindingsWe conducted qualitative in-depth interviews with 18 clinicians providing genomic risk assessment services to their patients in partnership with DNA Direct and Navigenics. Our findings suggest that clinicians learned most of what they knew about genomics directly from the commercial laboratories. Clinicians rely on the expertise of the commercial laboratories without the ability to critically evaluate the knowledge or assess risks.ConclusionsDTP service delivery model cannot guarantee that providers will have adequate expertise or sound clinical judgment. Even if clinicians want greater genomic knowledge, the current market structure is unlikely to build the independent substantive expertise of clinicians, but rather promote its continued outsourcing. Because commercial laboratories have the most “skin in the game” financially, genetics professionals and policymakers should scrutinize the scientific validity and clinical soundness of the process by which these laboratories interpret their findings to assess whether self-interested commercial sources are the most appropriate entities for gate-keeping genomic interpretation.
The Use of Garage Band within the PYP Curriculum – An Investigation of the British International School in Thailand
Creators: name: Muller, Mario Maxwell
Publisher: name: figshare
Year: 2019
Subjects: subject: 130202 Curriculum and Pedagogy Theory and Development
subject: FOS: Educational sciences
subject: 190409 Musicology and Ethnomusicology
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: This research paper aims to evaluate and confirm that through the use of Garage Band within the PYP Curriculum one can foster a passion and interest for music composition. Using music technology as an effective tool can enhance the PYP curriculum within a British International School. The focus of this research concentrated on St Andrews International School in Thailand where several learners in Grade 6 were interviewed through means of action research. This is a qualitative study valuable for music educators at international schools, who intend to use music technology and Garage Band in the near future. This program allowed learners to be creative and experiment with different sounds and textures, adding various instruments and using loops to create several compositions. The PYP programme allowed teachers to incorporate music technology into their curriculum, which meant that learners could be innovative and explore different elements of music.
title: Εκτίμηση της καταναλισκόμενης ενέργειας για θέρμανση και ψύξη σε τυπική κατοικία στην ευρύτερη περιοχή της Θεσσαλονίκης, με εφαρμογή της μεθόδου των βαθμοημέρων ψύξης και θέρμανσης
title: Estimation of the energy consumed for heating and cooling purposes in a typical house in the greater Thessaloniki area, applying cooling and heating degree days method
titleType: AlternativeTitle
Creators: name: Κοτάκης, Βασίλειος
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2023
Subjects: Βαθμοημέρες θέρμανσης
Βαθμοημέρες ψύξης
Ενεργειακά κτίρια
Οικονομικό κόστος
Θεσσαλονίκη

description: Στη συγκεκριμένη διπλωματική εργασία θα αντλήσουμε από δέκα (10) μετεωρολογικούς σταθμούς σε διάφορες περιοχές της Θεσσαλονίκης τα δεδομένα για βαθμοημέρες ψύξης και θέρμανσης για κάθε μία. Οι τιμές θα συλλεχθούν από το Εθνικό Αστεροσκοπείο Αθηνών και θα δείξουν τη ζήτηση ενέργειας για θέρμανση και ψύξη για μια κατοικία. Οι τιμές αυτές θα εφαρμοστούν σε μια μονοκατοικία σε κάθε μία από τις δέκα εξεταζόμενες περιοχές. Επειδή η διπλωματική αυτή αναφέρεται σε κτίρια, θα μας απασχολήσουν και τα ενεργειακά κτίρια. Θα γίνει, λοιπόν, ανάλυση τόσο και στη θερμομονωτική επάρκεια της μονοκατοικίας που έχει επιλεχθεί με την απαραίτητη μεθοδολογία και τα απαραίτητα σκαριφήματα προκειμένου να έχουμε μια απεικόνιση του προς μελέτη κτιρίου. Η μελέτη χωρίζεται σε δύο περιπτώσεις, όπου η πρώτη αναφέρεται σε μία τυπική θερμομόνωση που χαρακτηρίζει ένα κέλυφος της επικράτειας και η δεύτερη περίπτωση όπου στην κατοικία έχει γίνει μια ριζική ανακαίνιση στη θερμομόνωση. Για τις βαθμοημέρες ψύξης και θέρμανσης θα ακολουθηθεί μια συγκεκριμένη μεθοδολογία που θα αναλυθεί εκτενώς. Οι υπολογισμοί που θα προκύψουν θα δείξουν τις ενεργειακές ανάγκες του κτιρίου. Επομένως, για να γίνει ολοκληρωμένη η ανάλυση θα παρουσιαστούν αναλυτικά μεθοδολογία, πίνακες και διαγράμματα. Τέλος, θα βρεθεί ένα οικονομικό κόστος για κάθε έναν από τους εξεταζόμενους σταθμούς σε κάθε περίπτωση.
Challenges in Bridging Social Semantics and Formal Semantics on the Web
Creators: name: Gandon, Fabien Lucien
name: Buffa, Michel
name: Cabrio, Elena
name: Faron-Zucker, Catherine
name: Giboin, Alain
name: Thanh, Nhan Le
name: Mirbel, Isabelle
name: Sander, Peter
name: Tettamanzi, Andrea G. B.
name: Villata, Serena
Publisher: name: arXiv
Year: 2014
Subjects: subject: Artificial Intelligence (cs.AI)
subject: Information Retrieval (cs.IR)
subject: FOS: Computer and information sciences

description: This paper describes several results of Wimmics, a research lab which names stands for: web-instrumented man-machine interactions, communities, and semantics. The approaches introduced here rely on graph-oriented knowledge representation, reasoning and operationalization to model and support actors, actions and interactions in web-based epistemic communities. The re-search results are applied to support and foster interactions in online communities and manage their resources.
GDNF-Transfected Macrophages Produce Potent Neuroprotective Effects in Parkinson's Disease Mouse Model
Creators: name: Zhao, Yuling
name: He, Zhijian
name: Gupta, Richa
name: Bohnsack, John P.
name: Haney, Matthew J.
name: Kabanov, Alexander V.
name: Batrakova, Elena V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The pathobiology of Parkinson's disease (PD) is associated with the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) projecting to the striatum. Currently, there are no treatments that can halt or reverse the course of PD; only palliative therapies, such as replacement strategies for missing neurotransmitters, exist. Thus, the successful brain delivery of neurotrophic factors that promote neuronal survival and reverse the disease progression is crucial. We demonstrated earlier systemically administered autologous macrophages can deliver nanoformulated antioxidant, catalase, to the SNpc providing potent anti-inflammatory effects in PD mouse models. Here we evaluated genetically-modified macrophages for active targeted brain delivery of glial cell-line derived neurotropic factor (GDNF). To capitalize on the beneficial properties afforded by alternatively activated macrophages, transfected with GDNF-encoded pDNA cells were further differentiated toward regenerative M2 phenotype. A systemic administration of GDNF-expressing macrophages significantly ameliorated neurodegeneration and neuroinflammation in PD mice. Behavioral studies confirmed neuroprotective effects of the macrophage-based drug delivery system. One of the suggested mechanisms of therapeutic effects is the release of exosomes containing the expressed neurotropic factor followed by the efficient GDNF transfer to target neurons. Such formulations can serve as a new technology based on cell-mediated active delivery of therapeutic proteins that attenuate and reverse progression of PD, and ultimately provide hope for those patients who are already significantly disabled by the disease.
title: Μελέτη των χαρακτηριστικών των οχημάτων και των εκπομπών από τις οδικές μεταφορές στην Ελλάδα
title: Study of vehicle characteristics and emissions from road transport in Greece
titleType: AlternativeTitle
Creators: name: Παπακωνσταντίνου, Κωνσταντίνος
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2023
Subjects: Οδικές μεταφορές
Στόλος οχημάτων Ελλάδας
Κατανάλωση καυσίμου
Ατμοσφαιρική ρύπανση
Ατμοσφαιρικοί ρύποι
Καυσαέρια οχημάτων

description: Στην συγκεκριμένη εργασία θα μελετηθούν τα χαρακτηριστικά του στόλου των οχημάτων ανά νομό στην Ελλάδα, θα διερευνηθούν ποιοτικά και ποσοτικά οι ταξινομήσεις νέων οχημάτων, η κατανάλωση καυσίμου και το είδος κινητήρα. Θα μελετηθούν οι αλλαγές στη σύνθεση του στόλου διαχρονικά και θα γίνει μελέτη των εκπομπών από τις οδικές μεταφορές για την Ελλάδα. Θα χρησιμοποιηθούν δεδομένα από την ΕΛΣΤΑΤ, τη Eurostat, την Ευρωπαϊκή Ένωση Κατασκευαστών Αυτοκινήτων (European Automobile Manufacturers’ Association, or ACEA) και τη βάση δεδομένων εκπομπών EMEP (European Monitoring and Evaluation Programme). Στόχος είναι να διαπιστωθούν τα χαρακτηριστικά του στόλου των οχημάτων στην Ελλάδα και οι ρύποι που σχετίζονται με τη συγκεκριμένη πηγή ρύπανσης.
Gender-Based Screening for Chlamydial Infection and Divergent Infection Trends in Men and Women
Creators: name: Hobbs, Marcia
name: Ganapathi, Laxminarayana
name: Chromy, James
name: Tan, Sylvia
name: Muvva, Ravikiran
name: Roman, Anthony
name: Rogers, Susan M.
name: Miller, William C.
name: Eggleston, Elizabeth
name: Turner, Charles F.
name: Erbelding, Emily
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: ObjectivesTo assess the potential impact of chlamydial screening policy that recommends routine screening of women but not men.MethodsPopulation surveys of probability samples of Baltimore adults aged 18 to 35 years in 1997–1998 and 2006–2009 collected biospecimens to estimate trends in undiagnosed chlamydial infection. Survey estimates are compared to surveillance data on diagnosed chlamydial infections reported to the Health Department.ResultsPrevalence of undiagnosed chlamydial infection among men increased from 1.6% to 4.0%, but it declined from 4.3% to 3.1% among women (p = 0.028 for test of interaction). The annual (average) number of diagnosed infections was substantially higher among women than men in both time periods and increased among both men and women. Undiagnosed infection prevalence was substantially higher among black than non-black adults (4.0% vs 1.2%, p = 0.042 in 1997–98 and 5.5% vs 0.7%, p<0.001 in 2006–09).ConclusionDivergent trends in undiagnosed chlamydial infection by gender parallel divergent screening recommendations that encourage chlamydial testing for women but not for men.
Chemical evolution of the bulge of M31: predictions about abundance ratios
Creators: name: Marcon-Uchida, M. M.
name: Matteucci, F.
name: Lanfranchi, G. A.
name: Spitoni, E.
name: Grieco, V.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We aim at reproducing the chemical evolution of the bulge of M31 by means of a detailed chemical evolution model, including radial gas flows coming from the disk. We study the impact of the initial mass function, the star formation rate and the time scale for bulge formation on the metallicity distribution function of stars. We compute several models of chemical evolution using the metallicity distribution of dwarf stars as an observational constraint for the bulge of M31. Then, by means of the model which best reproduces the metallicity distribution function, we predict the [X/Fe] vs. [Fe/H] relations for several chemical elements (O, Mg, Si, Ca, C, N). Our best model for the bulge of M31 is obtained by means of a robust statistical method and assumes a Salpeter initial mass function, a Schmidt-Kennicutt law for star formation with an exponent k=1.5, an efficiency of star formation of $\sim 15\pm 0.27\, Gyr^{-1}$, and an infall timescale of $\sim 0.10\pm 0.03$Gyr. Our results suggest that the bulge of M31 formed very quickly by means of an intense star formation rate and an initial mass function flatter than in the solar vicinity but similar to that inferred for the Milky Way bulge. The [$α$/Fe] ratios in the stars of the bulge of M31 should be high for most of the [Fe/H] range, as is observed in the Milky Way bulge. These predictions await future data to be proven.
description: Accepted for publication by MNRAS
MIGNEX Case Study Brief TUR2 - Migration and development dynamics in Yenice, Turkey
Creators: name: Ensari, Pınar
name: Kavur, Nilay
name: Mazzilli, Caterina
Publisher: name: Peace Research Institute Oslo
Year: 2022

description: Farming is the major livelihood opportunity in Yenice, yet it is not appealing to young people. Socio-economic development is limited and internal out-migration is very common.

Key Takeaways

Many young adults perceive life as peaceful and secure in Yenice, yet a lack of jobs and quality education are major reasons for out-migration.

International migration is uncommon; people prefer to migrate within the province, mostly to nearby urban centres.

The recent opening of the Çanakkale 1915 Bridge has raised new hopes for trade and local economic growth.
Foresight and Social Epistemology. An Inquiry into the Epistemic Versatility of Futures Research and the Potential of a Socioepistemic Approach
Creators: name: Shala, Erduana
Publisher: name: Karlsruhe
Year: 2018
Subjects: Futures Research
Foresight
Epistemology
Philosophy of Science
Social Epistemology
Zukunftsforschung
Erkenntnistheorie
Wissenschaftstheorie

description: Die vorliegende Arbeit überprüft, inwiefern ein sozialepistemologischer Ansatz als Grundlage für Foresight tauglich ist. Hierzu wird zunächst die Ideengeschichte des Denkens über die Zukunft skizziert, die letztlich in der Herausbildung der Zukunftsforschung und in praktischen Ansätzen wie Foresight mündete. Anschließend wird eine Definition der Charakteristika von Foresight und dessen Abgrenzung zu anderen Ansätzen der Zukunftsforschung vorgenommen. Um Foresight wissenschaftstheoretisch einordnen zu können – bzw. um die Unmöglichkeit dieses Unterfangens aufzuzeigen – werden die maßgeblichen Strömungen der Wissenschaftsphilosophie umrissen, sowie gängige Theorien zur Zukunftsforschung und zu Foresight. Hierauf aufbauend, sowie auf Ansätzen der sozialen Erkenntnistheorie, welche die Rolle von Werten in wissenschaftlichen Prozessen berücksichtigen, wird ein Konzept für ein socio-epistemic foresight framework entwickelt. Dieses Framework ermöglicht es, Theorie und Praxis in Foresight einer wissenschaftlichen Kritik zu unterziehen, welche auch den geregelten Einfluss von Werten und verschiedene Objektivitiätsbegriffe berücksichtigt. Longinos These Wissenschaft sei soziales Wissen folgend (Longino 1990), ließe sich demnach Foresight als seine auf sozialem Wissen basierende Wissenschaft begründen.
Genetic and Dietary Determinants of Insulin-Like Growth Factor (IGF)-1 and IGF Binding Protein (BP)-3 Levels among Chinese Women
Creators: name: Wang, Qiong
name: Qi, Ya-na
name: Liu, Li
name: McCullough, Lauren E.
name: Li, Jia-yuan
name: Miller, Erline
name: Zhang, Jing
name: Yang, Chun-xia
name: Li, Hui
name: Smith, Jennifer S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: BackgroundHigher insulin-like growth factor (IGF)-1 and lower IGF binding protein (BP)-3 levels have been associated with higher commoncancer risk, including breast cancer. Dietary factors, genetic polymorphisms, and the combination of both may influence circulating IGF-1 and IGFBP-3 serum concentrations.MethodsFrom September 2011 to July 2012, we collected demographic, reproductive and dietary data on 143 women (≥40 years). We genotyped IGF-1 rs1520220 and IGFBP-3 rs2854744 and measured circulating IGF-1 and IGFBP-3 levels in serum. Covariance analyses were used to estimate the associations of serum levels of IGF-1 and IGFBP-3, and the molar ratio of IGF-1to IGFBP-3 with IGF-1 rs1520220 and IGFBP-3 rs2854744 genotypes. We subsequently assessed the combined influence of genetics and diet (daily intake of protein, fat and soy isoflavones) on IGF-1 and IGFBP-3 levels.ResultsAmong women aged less than 50 years, circulating IGF-1 serum levels were significantly lower for those with CC genotype for IGF-1 rs1520220 than levels for those with the GC or GG genotypes (in recessive model: P = 0.007).In gene-diet analyses among these women, we found carrying CC genotype for IGF-1 rs1520220 and high soy isoflavone intake tend to be associated with lower circulating IGF-1 levels synthetically (P = 0.002). Women with GG or GC genotypes for IGF-1 rs1520220 and with low intake of soy isoflavones had the highest levels of circulating IGF-1 (geometric mean [95% CI]: 195 [37, 1021] µg/L). Comparatively, women with both the CC genotype and high soy intake had the lowest levels of circulating IGF-1 (geometric mean [95% CI]: 120 [38,378] µg/L).ConclusionsIGF-1 serum levels are significantly lower among women with the CC genotype for IGF-1-rs1520220. High soy isoflavone intake may interact with carrying CC genotype for IGF-1-rs1520220 to lower women's serum IGF-1 levels more.
Method to Address Complexity in Organizations Based on a Comprehensive Overview
Creators: name: Revina, Aleksandra
name: Aksu, Ünal
name: Meister, Vera G.
Publisher: name: Technische Universität Berlin
Year: 2021
Subjects: subject: 004 Datenverarbeitung; Informatik
subject: organizational complexity
subject: technological complexity
subject: textual complexity
subject: morphological box
subject: goal question metric

description: Digitalization increasingly enforces organizations to accommodate changes and gain resilience. Emerging technologies, changing organizational structures and dynamic work environments bring opportunities and pose new challenges to organizations. Such developments, together with the growing volume and variety of the exchanged data, mainly yield complexity. This complexity often represents a solid barrier to efficiency and impedes understanding, controlling, and improving processes in organizations. Hence, organizations are prevailingly seeking to identify and avoid unnecessary complexity, which is an odd mixture of different factors. Similarly, in research, much effort has been put into measuring, reviewing, and studying complexity. However, these efforts are highly fragmented and lack a joint perspective. Further, this negatively affects the complexity research acceptance by practitioners. In this study, we extend the body of knowledge on complexity research and practice addressing its high fragmentation. In particular, a comprehensive literature analysis of complexity research is conducted to capture different types of complexity in organizations. The results are comparatively analyzed, and a morphological box containing three aspects and ten features is developed. In addition, an established multi-dimensional complexity framework is employed to synthesize the results. Using the findings from these analyses and adopting the Goal Question Metric, we propose a method for complexity management. This method serves to provide key insights and decision support in the form of extensive guidelines for addressing complexity. Thus, our findings can assist organizations in their complexity management initiatives.
Understanding Ethnomusicology within a South African Context – A discourse of African Musicology and Culture
Creators: name: Muller, Mario Maxwell
Publisher: name: figshare
Year: 2019
Subjects: subject: 190409 Musicology and Ethnomusicology
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: This research paper discusses the difference between Ethnomusicology and African Musicology with reference to the work of Professor Geoff Mapaya. The importance of culture and identity within music and the cultural differences one explore through music within a South African context with the views shared within a Western Perspective. The objective of this paper is to clearly underpin the two separate entities and to enlighten future researchers how to differentiate between the two, giving rise to a new era for music scholars to explore, research and elaborate. It is a discourse of African Musicology and Culture within a South African Context.
Genetic Diversity of the KIR/HLA System and Outcome of Patients with Metastatic Colorectal Cancer Treated with Chemotherapy
Creators: name: Zagonel, Vittorina
name: Racanelli, Vito
name: Buonadonna, Angela
name: Caggiari, Laura
name: Talamini, Renato
name: De Re, Valli
name: Andrea, Mario D’
name: Toffoli, Giuseppe
name: Innocenti, Federico
name: Cecchin, Erika
name: De Zorzi, Mariangela
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: ObjectiveTo explore genes of the killer-cell immunoglobulin-like receptor (KIR) and of the HLA ligand and their relationship with the outcome of metastatic colorectal cancer (mCRC) patients treated with first-line 5-fluorouracil, leucovorin, and irinotecan (FOLFIRI).MethodsA total of 224 mCRC patients were screened for KIR/HLA typing. The determination of the KIR/HLA combinations was based upon the gene content and variants. Genetic associations with complete response (CR), time to progression (TTP) and overall survival (OS) were evaluated by calculating odds and hazard ratios. Multivariate modeling with prognostic covariates was also performed.ResultsFor CR, the presence of KIR2DL5A, 2DS5, 2DS1, 3DS1, and KIR3DS1/HLA-Bw4-I80 was associated with increased CR rates, with median ORs ranging from 2.1 to 4.3, while the absence of KIR2DS4 and 3DL1 was associated with increased CR rates (OR 3.1). After univariate analysis, patients that underwent resective surgery of tumor, absence of KIR2DS5, and presence of KIR3DL1/HLA-Bw4-I80 showed a significant better OS (HR 1.5 to 2.8). Multivariate analysis identified as parameters independently related to OS the type of treatment (surgery; HR 2.0) and KIR3DL1/HLA-Bw4-I80 genotype (HR for T-I80 2.7 and for no functional KIR/HLA interaction 1.8). For TTP, no association with KIR/HLA genes was observed.ConclusionThis study, for the first time, evidences that the genotyping for KIR-HLA pairs are found predictive markers associated with complete response and improves overall survival prediction of FOLFIRI treatment response in metastatic colorectal cancer. These results suggest a role of the KIR/HLA system in patient outcome, and guide new research on the immunogenetics of mCRC through mechanistic studies and clinical validation.
Genome-Wide Association Scan for Variants Associated with Early-Onset Prostate Cancer
Creators: name: Gao, Zhengrong
name: Ribado, Jessica V.
name: Li, Jin
name: Duan, Qing
name: Johnson, Anna M.
name: Isaacs, William B.
name: Wang, Yunfei
name: Li, Ge
name: Cooney, Kathleen A.
name: Xu, Jianfeng
name: Lu, Yurong
name: Keele, Gregory R.
name: Zuhlke, Kimberly A.
name: Zheng, Siqun
name: Lange, Ethan M.
name: Li, Yun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Prostate cancer is the most common non-skin cancer and the second leading cause of cancer related mortality for men in the United States. There is strong empirical and epidemiological evidence supporting a stronger role of genetics in early-onset prostate cancer. We performed a genome-wide association scan for early-onset prostate cancer. Novel aspects of this study include the focus on early-onset disease (defined as men with prostate cancer diagnosed before age 56 years) and use of publically available control genotype data from previous genome-wide association studies. We found genome-wide significant (p<5×10−8) evidence for variants at 8q24 and 11p15 and strong supportive evidence for a number of previously reported loci. We found little evidence for individual or systematic inflated association findings resulting from using public controls, demonstrating the utility of using public control data in large-scale genetic association studies of common variants. Taken together, these results demonstrate the importance of established common genetic variants for early-onset prostate cancer and the power of including early-onset prostate cancer cases in genetic association studies.
title: 	Biocomposite cement based on magnesium potassium phosphate and K-carrageenan intended as an injectable bone substitute
Creators: name: Wojtala, Monika
name: Ronowska, Anna
name: Kozłowska, Justyna
name: Mielewczyk-Gryń, Aleksandra
name: Wekwejt, Marcin
Publisher: name: Publishing House of Poznan University of Technology
Year: 2023

description: 5th Conference on Biomedical Engineering. Book of Abstracts, 43-44
S. Nikolaidou-Arampatzi, Euripides’ Ino. Commentary, Reconstruction, Text, and Translation
Creators: name: Redondo, Jordi
Publisher: name: Frammenti sulla Scena (online)
Year: 2024

description: Recensione di S. Nikolaidou-Arampatzi, Euripides’ Ino. Commentary, Reconstruction, Text, and Translation
description: Frammenti sulla Scena (online), N. 4 · 2023
Genome-Wide Association Studies and Heritability Estimates of Body Mass Index Related Phenotypes in Bangladeshi Adults
Creators: name: Kibriya, Muhammad G.
name: Ahsan, Habibul
name: Jasmine, Farzana
name: Islam, Tariqul
name: Rahman, Mahfuzar
name: Pierce, Brandon
name: Parvez, Faruque
name: Baron, John A.
name: Scannell Bryan, Molly
name: Ahmed, Alauddin
name: Yunus, Muhammad
name: Rakibuz-Zaman, Muhammad
name: Tong, Lin
name: Roy, Shantanu
name: Argos, Maria
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Many health outcomes are influenced by a person's body mass index, as well as by the trajectory of body mass index through a lifetime. Although previous research has established that body mass index related traits are influenced by genetics, the relationship between these traits and genetics has not been well characterized in people of South Asian ancestry. To begin to characterize this relationship, we analyzed the association between common genetic variation and five phenotypes related to body mass index in a population-based sample of 5,354 Bangladeshi adults. We discovered a significant association between SNV rs347313 (intron of NOS1AP) and change in body mass index in women over two years. In a linear mixed-model, the G allele was associated with an increase of 0.25 kg/m2 in body mass index over two years (p-value of 2.3·10−8). We also estimated the heritability of these phenotypes from our genotype data. We found significant estimates of heritability for all of the body mass index-related phenotypes. Our study evaluated the genetic determinants of body mass index related phenotypes for the first time in South Asians. The results suggest that these phenotypes are heritable and some of this heritability is driven by variation that differs from those previously reported. We also provide evidence that the genetic etiology of body mass index related traits may differ by ancestry, sex, and environment, and consequently that these factors should be considered when assessing the genetic determinants of the risk of body mass index-related disease.
Genomic Assortative Mating in Marriages in the United States
Creators: name: Guo, Guang
name: Randall, Thomas
name: Liu, Hexuan
name: Wang, Lin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Assortative mating in phenotype in human marriages has been widely observed. Using genome-wide genotype data from the Framingham Heart study (FHS; number of married couples = 989) and Health Retirement Survey (HRS; number of married couples = 3,474), this study investigates genomic assortative mating in human marriages. Two types of genomic marital correlations are calculated. The first is a correlation specific to a single married couple “averaged” over all available autosomal single-nucleotide polymorphism (SNPs). In FHS, the average married-couple correlation is 0.0018 with p = 3×10−5; in HRS, it is 0.0017 with p = 7.13×10−13. The marital correlation among the positively assorting SNPs is 0.001 (p = .0043) in FHS and 0.015 (p = 1.66×10−24) in HRS. The sizes of these estimates in FHS and HRS are consistent with what are suggested by the distribution of the allelic combination. The study also estimated SNP-specific correlation “averaged” over all married couples. Suggestive evidence is reported. Future studies need to consider a more general form of genomic assortment, in which different allelic forms in homologous genes and non-homologous genes result in the same phenotype.
Germline Variation in Colorectal Risk Loci Does Not Influence Treatment Effect or Survival in Metastatic Colorectal Cancer
Creators: name: Renfro, Lindsay A.
name: Goldberg, Richard M.
name: Ambadwar, Pratibha
name: McLeod, Howard
name: Sargent, Daniel J.
name: Sanoff, Hanna K.
name: Poonnen, Pradeep
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: BackgroundColorectal cancer (CRC) risk is partly conferred by common, low-penetrance single nucleotide polymorphisms (SNPs). We hypothesized that these SNPs are associated with outcomes in metastatic CRC.MethodsSix candidate SNPs from 8q24, 10p14, 15q13, 18q21 were investigated for their association with response rate (RR), time to progression (TTP) and overall survival (OS) among 524 patients treated on a phase III clinical trial of first-line chemotherapy for metastatic CRC.Resultsrs10795668 was weakly associated with TTP (p = 0.02), but not RR or OS. No other SNPs carried statistically significant HRs for any of the primary outcomes (RR, TTP or OS).ConclusionCommon low-penetrance CRC risk SNPs were not associated with outcomes among patients with metastatic CRC.
Glycerol-3-Phosphate Acyltranferase-2 Behaves as a Cancer Testis Gene and Promotes Growth and Tumorigenicity of the Breast Cancer MDA-MB-231 Cell Line
Creators: name: Soler-Gerino, Mercedes C.
name: Pellon-Maison, Magali
name: Montanaro, Mauro A.
name: Lacunza, Ezequiel
name: Garcia-Fabiani, Maria B.
name: Cattaneo, Elizabeth R.
name: Coleman, Rosalind A.
name: Gonzalez-Baro, Maria R.
name: Quiroga, Ivana Y.
name: Abba, Martin C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The de novo synthesis of glycerolipids in mammalian cells begins with the acylation of glycerol-3-phosphate, catalyzed by glycerol-3-phosphate acyltransferase (GPAT). GPAT2 is a mitochondrial isoform primarily expressed in testis under physiological conditions. Because it is aberrantly expressed in multiple myeloma, it has been proposed as a novel cancer testis gene. Using a bioinformatics approach, we found that GPAT2 is highly expressed in melanoma, lung, prostate and breast cancer, and we validated GPAT2 expression at the protein level in breast cancer by immunohistochemistry. In this case GPAT2 expression correlated with a higher histological grade. 5-Aza-2′ deoxycytidine treatment of human cells lines induced GPAT2 expression suggesting epigenetic regulation of gene expression. In order to evaluate the contribution of GPAT2 to the tumor phenotype, we silenced its expression in MDA-MB-231 cells. GPAT2 knockdown diminished cell proliferation, anchorage independent growth, migration and tumorigenicity, and increased staurosporine-induced apoptosis. In contrast, GPAT2 over-expression increased cell proliferation rate and resistance to staurosporine-induced apoptosis. To understand the functional role of GPAT2, we performed a co-expression analysis in mouse and human testis and found a significant association with semantic terms involved in cell cycle, DNA integrity maintenance, piRNA biogenesis and epigenetic regulation. Overall, these results indicate the GPAT2 would be directly associated with the control of cell proliferation. In conclusion, we confirm GPAT2 as a cancer testis gene and that its expression contributes to the tumor phenotype of MDA-MB-231 cells.
Kinematics and simulations of the stellar stream in the halo of the Umbrella Galaxy
Creators: name: Foster, Caroline
name: Lux, Hanni
name: Romanowsky, Aaron J.
name: Martinez-Delgado, David
name: Zibetti, Stefano
name: Arnold, Jacob A.
name: Brodie, Jean P.
name: Ciardullo, Robin
name: GaBany, R. Jay
name: Merrifield, Michael R.
name: Singh, Navtej
name: Strader, Jay
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We study the dynamics of faint stellar substructures around the Umbrella Galaxy, NGC 4651, which hosts a dramatic system of streams and shells formed through the tidal disruption of a nucleated dwarf elliptical galaxy. We elucidate the basic characteristics of the system (colours, luminosities, stellar masses) using multi-band Subaru/Suprime-Cam images. The implied stellar mass-ratio of the ongoing merger event is about 1:50. We identify candidate kinematic tracers (globular clusters, planetary nebulae, H ii regions), and follow up a subset with Keck/DEIMOS spectroscopy to obtain velocities. We find that 15 of the tracers are likely associated with halo substructures, including the probable stream progenitor nucleus. These objects delineate a kinematically cold feature in position-velocity phase space. We model the stream using single test-particle orbits, plus a rescaled pre-existing N-body simulation. We infer a very eccentric orbit with a period of roughly 0.35 Gyr and turning points at approximately 2-4 and 40 kpc, implying a recent passage of the satellite through the disc, which may have provoked the visible disturbances in the host galaxy. This work confirms that the kinematics of low surface brightness substructures can be recovered and modeled using discrete tracers - a breakthrough that opens up a fresh avenue for unraveling the detailed physics of minor merging.
description: 23 pages, 10 figures, 7 tables, accepted for publication in MNRAS 3D animated gif N-body model: http://sages.ucolick.org/downloads/Umbrella_3d.gif
“Fetonte 2.0”: attività di riscrittura da frammenti del Fetonte euripideo
Creators: name: Pelliccio, Francesco
name: Liceo Cavour, Classe 4G
Publisher: name: Frammenti sulla Scena (online)
Year: 2024

description: This article outlines the method used to reconstruct some scenes of Euripides' Phaethon based on the preserved fragments.
description: Frammenti sulla Scena (online), N. 4 · 2023