cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A parallelized, perfused 3D triculture model of leukemia for in vitro drug testing of chemotherapeutics
Creators: name: Zippel, Sabrina
name: Dilger, Nadine
name: Chatterjee, Chandralekha
name: Raic, Annamarija
name: Brenner-Weiß, Gerald
name: Schadzek, Patrik
name: Rapp, Bastian E
name: Lee-Thedieck, Cornelia
Publisher: name: Bristol : IOP Publ.
Year: 2022
Subjects: subject: Chemotherapeutics
subject: Drug testing
subject: Hematopoietic stem and progenitor cells
subject: Leukemic niche
subject: Magnetic hydrogels
subject: Dewey Decimal Classification::500 | Naturwissenschaften::570 | Biowissenschaften, Biologie

description: Leukemia patients undergo chemotherapy to combat the leukemic cells (LCs) in the bone marrow. During therapy not only the LCs, but also the blood-producing hematopoietic stem and progenitor cells (HSPCs) may be destroyed. Chemotherapeutics targeting only the LCs are urgently needed to overcome this problem and minimize life-threatening side-effects. Predictive in vitro drug testing systems allowing simultaneous comparison of various experimental settings would enhance the efficiency of drug development. Here, we present a three-dimensional (3D) human leukemic bone marrow model perfused using a magnetic, parallelized culture system to ensure media exchange. Chemotherapeutic treatment of the acute myeloid leukemia cell line KG-1a in 3D magnetic hydrogels seeded with mesenchymal stem/stromal cells (MSCs) revealed a greater resistance of KG-1a compared to 2D culture. In 3D tricultures with HSPCs, MSCs and KG-1a, imitating leukemic bone marrow, HSPC proliferation decreased while KG-1a cells remained unaffected post treatment. Non-invasive metabolic profiling enabled continuous monitoring of the system. Our results highlight the importance of using biomimetic 3D platforms with proper media exchange and co-cultures for creating in vivo-like conditions to enable in vitro drug testing. This system is a step towards drug testing in biomimetic, parallelized in vitro approaches, facilitating the discovery of new anti-leukemic drugs.
Observations and theoretical implications of GRB 970228
Creators: name: Reichart, D.E.
Publisher: name: Institute of Physics Publishing
Year: 1997

description: GRB 970228 is the first gamma-ray burst (GRB) for which prolonged postburst transient X-ray, optical, and infrared emission has been detected. Recent Hubble Space Telescope (HST) observations show that the transient consists of two components: a point source, which is known to be fading, and an extended source, which is possibly fading. I fit standard fireball remnant models to the first month of X-ray, optical, and infrared measurements, which may be done without assuming a GRB distance scale. I show that its emission is consistent with that of the remnant of a relativistically expanding impulsive fireball in which a forward shock dominates the emission of the GRB event: the piston model. However, two discrepant measurements may indicate that the postburst flux varies by a factor of ∼3 on timescales of days or weeks. Furthermore, using the HST observations and the fitted model, I show that the extended object probably is fading, which may place GRB 970228 at Galactic halo distances.
Additional file 2 of Landscape genomics reveals regions associated with adaptive phenotypic and genetic variation in Ethiopian indigenous chickens
Creators: name: Kebede, Fasil Getachew
name: Derks, Martijn F.L.
name: Dessie, Tadelle
name: Hanotte, Olivier
name: Barros, Carolina Pita
name: Crooijmans, Richard P.M.A.
name: Komen, Hans
name: Bastiaansen, John W.M.
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 2
Structural properties of fractals with positive Lebesgue measures
Creators: name: Anitas, Eugen M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Small-angle scattering (SAS) data which show a succession of power-law decays with decreasing values of scattering exponents, can be described in terms of fractal structures with positive Lebesgue measure (fat fractals). In this work we present a theoretical model for fat fractals and show how one can extract structural information about the underlying fractal using SAS method, for the well known fractals existing in the literature: Vicsek and Menger sponge. We calculate analytically the fractal structure factor and study its properties in momentum space. The models allow us to obtain the fractal dimension at each structural level inside the fractal, the number of particles inside the fractal and about the most common distances between the center of mass of the particles.
description: Work presented at the 3-rd edition of International Conference on Mathematical Modeling in Physical Sciences
Material stocks as drivers of global GHG emissions. New insights from analyzing the stock flow service nexus
Creators: name: Haberl, Helmut
name: Wiedenhofer, Dominik
name: Krausmann, Fridolin
Publisher: name: Zenodo
Year: 2019

description: Presentation at the Engaging Economics of Change“ 12th Biannial Conference of the Canadian Society for Ecological Economics (CANSEE), Waterloo, 22 25 May 2019
Comparison concept and quality metrics for GNSS antenna calibrations: Cause and effect on regional GNSS networks
Creators: name: Kersten, Tobias
name: Kröger, Johannes
name: Schön, Steffen
Publisher: name: Heidelberg : Springer
Year: 2022
Subjects: subject: Antenna
subject: Calibration
subject: Carrier phase centre offset
subject: Carrier phase centre variation
subject: GNSS
subject: PCC
subject: PCO
subject: PCV
subject: PPP
subject: Regional GNSS networks
subject: Dewey Decimal Classification::500 | Naturwissenschaften::550 | Geowissenschaften

description: Precise values for absolute receiver antenna phase centre corrections (PCC) are one prerequisite for high-quality GNSS applications. Currently, antenna calibrations are performed by different institutes using a robot in the field or in an anechoic chamber. The differences between the antenna patterns are significant and require a sound comparison concept and a detailed study to quantify the impact on geodetic parameters, such as station coordinates, zenith wet delays (ZWDs) or receiver clock estimates. Furthermore, a discussion on acceptable pattern uncertainties is needed. Therefore, a comparison strategy for receiver antenna calibration values is presented using a set of individually and absolutely calibrated Leica AR25 antennas from the European Permanent Network (EPN), both from the robot (Geo++ company) and from the chamber approach (University of Bonn). Newly developed scalar metrics and their benefits are highlighted and discussed in relation to further structural analysis. With our metrics, properties of 25 patterns pairs (robot/chamber) could be used to successfully assign seven individual groups. The impact of PCC on the estimated parameters depends on the PCC structure, its sampling by the satellite distribution and the applied processing parameters. A regional sub-network of the EPN is analysed using the double difference (DD) and the precise point positioning (PPP) methods. For DD, depending on the antenna category differences in the estimated parameters between 1 and 12 mm are identified also affecting the ZWDs. For PPP, the consistency of the observables, i.e. potential differences in the reference point of carrier phase and code observations, additionally affects the distribution among the different parameters and residuals.
Real-time simulated storm surge predictions during Hurricane Michael (2018)
Creators: name: Luettich, R.A., Jr.
name: Hagen, S.C.
name: Bilskie, M.V.
name: Fleming, J.G.
name: Asher, T.G.
name: Miller, P.W.
Publisher: name: American Meteorological Society
Year: 2022

description: Storm surge caused by tropical cyclones can cause overland flooding and lead to loss of life while damaging homes, businesses, and critical infrastructure. In 2018, Hurricane Michael made landfall near Mexico Beach, FL, on 10 October with peak wind speeds near 71.9 m s-1 (161 mph) and storm surge over 4.5 m NAVD88. During Hurricane Michael, water levels and waves were predicted near real-time using a deterministic, depth-averaged, high-resolution ADCIRC+SWAN model of the northern Gulf of Mexico. The model was forced with an asymmetrical parametric vortex model (GAHM) based on Michael's National Hurricane Center (NHC) forecast track and strength. The authors report errors between simulated and observed water level time-series, peak water level, and timing of peak for NHC Advisories. Forecasts of water levels were within 0.5 m of observations, and the timing of peak water levels was within 1 hr as early as 48 hr before Michael’s eventual landfall. We also examined the effect of adding far-field meteorology in our TC vortex model for use in real-time forecasts. In general, we found that including far-field meteorology by blending the TC vortex with a basin-scale NWP product improved water level forecasts. However, we note that divergence between the NHC forecast track and the forecast track of the meteorological model supplying the far-field winds represents a potential limitation to operationalizing a blended wind field surge product. The approaches and data reported herein provide a transparent assessment of water level forecasts during Hurricane Michael and highlight potential future improvements for more accurate predictions.
Application of the ecosystem services concept in stakeholder communication—Results of a workshop including a planning game at the Lower Mulde River (Dessau-Roßlau, Germany)
Creators: name: Gapinski, Cedric M.
name: Vollheyde, Anna‐Lena
name: Haaren, Christina Von
Publisher: name: Berlin : Wiley-VCH
Year: 2022
Subjects: subject: ecosystem services
subject: landscape planning
subject: participatory planning
subject: river landscape
subject: stakeholder communication
subject: Dewey Decimal Classification::500 | Naturwissenschaften::570 | Biowissenschaften, Biologie
subject: Dewey Decimal Classification::500 | Naturwissenschaften::550 | Geowissenschaften

description: The concept of ecosystem services (ES) is a powerful tool for communicating with stakeholders because it highlights the benefits of ecosystems for people and demonstrates their economic importance through monetized values. However, this hypothesis has rarely been substantiated in the context of local landscape planning. To investigate which ecosystem services information formats (ESIF) stakeholders prefer in decision situations, we experimented with a highly conflictual planning situation about the Lower Mulde restoration in Germany. We invited local stakeholders to a so-called ‘future vision workshop’. It included a paper-based, noncompetitive planning game, which combined the freedom of choice with strict rules for justifying the proposed measures. We tested how often participants used different ESIFs to justify their decisions, focusing on quantification, monetization, and the default qualitative (ordinal-scaled) format applied in landscape planning. A total of 17 representatives from stakeholder groups such as nature conservation, recreation, and local politics attended. We provided information on four ES and eight related measure proposals to the stakeholders, who used them to select, locate, and justify actions for the area's future development. The participants applied the ordinal-qualitative format in more than two-thirds of the decisions. Quantification and monetization were used with approximately equal frequency, mostly for measures that favoured flood risk regulation. Actions supporting habitat provision and biodiversity were justified exclusively in ordinal-qualitative terms. Instead of our provided quantifications, some participants mentioned numbers they were already familiar with before. They also partly doubted our monetization approaches. In conclusion, we recommend combined and context-specific uses of several ESIFs, while using the ordinal-qualitative format as the basis. Furthermore, the participants appreciated the workshop and requested that the results be presented to the city council. The workshop also confirmed that the ES concept is challenging to understand, especially for laypeople unfamiliar with ES and landscape planning.
Evaluation of system 3 ans SIS
Creators: name: ARIES WP15 Members
Publisher: name: Zenodo
Year: 2020

description: The ARIES WP15 program deals with the optimization of superconducting films for the use in accelerating structures. In the present approach, all production steps necessary to arrive at a successful coating are revisited, from substrate preparation to sample handling to the actual film deposition. These steps are performed on wafer samples, and in an intermediate step, prior to doing an actual coating on cavities, on QPR-samples (Quadrupole Resonator-samples) that allow for a characterisation under real accelerator-like conditions. In continuation of the previously reported results, sample manufacturing and DC-characterisation has progressed towards two additional systems: NbN and SIS. The procedures leading to an optimized sample are described in detail.
description: {"references": ["ARIES Del15.3"]}
Field topologies in ideal and near ideal magnetohydrodynamics and vortex dynamics
Creators: name: Low, B. C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Magnetic field topology frozen in ideal magnetohydrodynamics (MHD) and its breakage in near ideal MHD are reviewed in two parts. The first part gives a physically complete description of the frozen in field topology, taking magnetic flux conservation as fundamental and treating four topics, Eulerian and Lagrangian descriptions of MHD, Chandrasekhar-Kendall and Euler-potential field representations, magnetic helicity, and inviscid vortex dynamics in comparison to ideal MHD. A corollary clarifies the challenge of achieving a high degree of the frozen in condition in numerical MHD. The second part treats field topology breakage centered on the Parker Magnetostatic Theorem on a general incompatibility of a continuous magnetic field with the dual demand of force free equilibrium and an arbitrarily prescribed, 3D field topology. Preserving field topology as a global constraint readily results in formation of tangential magnetic discontinuities, i.e., electric current sheets of zero thickness. A similar incompatibility is present in the steady, force and thermal balance of a heated radiating fluid subject to an anisotropic thermal flux conducted strictly along the frozen in magnetic field in the low beta limit. In a weakly resistive fluid the thinning of current sheets by these incompatibilities inevitably results in sheet dissipation, resistive heating and topological changes in the field despite the small resistivity. Faraday induction drives but also macroscopically limits this mode of energy dissipation, storing free energy in self organized, ideal MHD structures. This property of MHD turbulence captured by the Taylor hypothesis is reviewed in relation to the Sun's corona, calling for a basic quantitative description of the breakdown of flux conservation in the low resistivity limit. A cylindrical, initial boundary value problem provides specificity in the review.
description: Review article, 20 pages, 2 figures, 158 references. see http://download.hao.ucar.edu/pub/low/Low_Sci_China-Phys_Mech_Astron_2015_58-015201.pdf
Self-made transparent optoacoustic detector for measurement of skin lesion thickness in vivo
Creators: name: Fedorov Kukk, Anatoly
name: Blumenröther, Elias
name: Roth, Bernhard
Publisher: name: Bristol : IOP Publ.
Year: 2022
Subjects: subject: optoacoustics
subject: photoacoustics
subject: skin cancer depth measurements in vivo
subject: transparent detector
subject: Dewey Decimal Classification::600 | Technik::610 | Medizin, Gesundheit

description: In skin cancer diagnosis and treatment, one of the key factors is tumor depth, which is connected to the severity and the required excision depth. Optoacoustical (OA) imaging is a relatively popular technique that provides information based on the optical absorption of the sample. Although often demonstrated with ex vivo measurements or in vivo imaging on parts of small animals, in vivo measurements on humans are more challenging. This is presumably because it is too time consuming and the required excitation pulse energies and their number exceed the allowed maximum permissible exposure (MPE). Here, we demonstrate thickness measurements with a transparent optoacoustical detector of different suspicious skin lesions in vivo on patients. We develop the signal processing technique to automatically convert the raw signal into thickness via deconvolution with the impulse response function. The transparency of the detector allows optical excitation with the pulsed laser to be performed perpendicularly on the lesion, in contrast to the conventional illumination from the side. For validation, the measured results were compared to the histological thickness determined after excision. We show that this simple transparent detector allows to determine the thickness of a lesion and thus, aid the dermatologist to estimate the excision depth in the future.
Stroke Prevention: Education and Barriers for Physical and Occupational Therapists Caring for Older Adults
Creators: name: Perry, Susan B.
name: Billek-Sawhney, Barbara
name: Schreiber, Jodi
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Aims: Describe the frequency of common stroke prevention education topics provided by occupational and physical therapists (OTs/PTs) to individuals at risk for stroke; summarize barriers to such education Methods: OT/PT professional association subgroups were surveyed regarding prevention education for individuals with risk factors, transient ischemic attack, and stroke, and barriers to such education. Results: A total of 293 therapists completed the survey, 11% OTs and 89% PTs. Education about risk/symptoms (61% of respondents) and activity/exercise (60%) was most commonly provided. The most frequently cited barriers to education were compromised health literacy of the patient/caregiver (62%), lack of interest by the patient/caregiver (51%), and lack of time (46%). Conclusion: The proportion of OTs/PTs providing stroke prevention education appears to be suboptimal. Therapist knowledge, patient characteristics, and institutional constraints were common barriers. Since stroke risk increases with age, reducing risk by identifying and eliminating barriers may help improve health of older adults.
Investigating Strategies for Clause Recommendation
Creators: name: Joshi, Sagar
name: Balaji, Sumanth
name: Thomas, Jerrin
name: Garimella, Aparna
name: Varma, Vasudeva
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computation and Language (cs.CL)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences
subject: I.2.7

description: Clause recommendation is the problem of recommending a clause to a legal contract, given the context of the contract in question and the clause type to which the clause should belong. With not much prior work being done toward the generation of legal contracts, this problem was proposed as a first step toward the bigger problem of contract generation. As an open-ended text generation problem, the distinguishing characteristics of this problem lie in the nature of legal language as a sublanguage and the considerable similarity of textual content within the clauses of a specific type. This similarity aspect in legal clauses drives us to investigate the importance of similar contracts' representation for recommending clauses. In our work, we experiment with generating clauses for 15 commonly occurring clause types in contracts expanding upon the previous work on this problem and analyzing clause recommendations in varying settings using information derived from similar contracts.
description: Published in Legal Knowledge and Information Systems (JURIX) 2022. (10 pages, 4 figures)
An Itō formula in the space of tempered distributions
Creators: name: Bhar, Suprio
Publisher: name: arXiv
Year: 2014
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: Primary: 60H05, Secondary: 60H10, 60H15

description: We extend the Itō formula \cite{MR1837298}*{Theorem 2.3} for semimartingales with rcll paths. We also comment on Local time process of such semimartingales. We apply the Itō formula to Lévy processes to obtain existence of solutions to certain classes of stochastic differential equations in the Hermite-Sobolev spaces.
Using Machine-Learning for the Damage Detection of Harbour Structures
Creators: name: Hake, Frederic
name: Göttert, Leonard
name: Neumann, Ingo
name: Alkhatib, Hamza
Publisher: name: Basel : MDPI
Year: 2022
Subjects: subject: damage detection
subject: infrastructure
subject: laserscanning
subject: machine-learning
subject: multibeam echo-sounder
subject: Dewey Decimal Classification::600 | Technik::620 | Ingenieurwissenschaften und Maschinenbau

description: The ageing infrastructure in ports requires regular inspection. This inspection is currently carried out manually by divers who sense the entire below-water infrastructure by hand. This process is cost-intensive as it involves a lot of time and human resources. To overcome these difficulties, we propose scanning the above and below-water port structure with a multi-sensor system, and by a fully automated process to classify the point cloud obtained into damaged and undamaged zones. We make use of simulated training data to test our approach because not enough training data with corresponding class labels are available yet. Accordingly, we build a rasterised height field of a point cloud of a sheet pile wall by subtracting a computer-aided design model. The latter is propagated through a convolutional neural network, which detects anomalies. We make use of two methods: the VGG19 deep neural network and local outlier factors. We showed that our approach can achieve a fully automated, reproducible, quality-controlled damage detection, which can analyse the whole structure instead of the sample-wise manual method with divers. We were able to achieve valuable results for our application. The accuracy of the proposed method is 98.8% following a desired recall of 95%. The proposed strategy is also applicable to other infrastructure objects, such as bridges and high-rise buildings.
Improving Observability of Stochastic Complex Networks under the Supervision of Cognitive Dynamic Systems
Creators: name: Fatemi, Mehdi
name: Setoodeh, Peyman
name: Haykin, Simon
Publisher: name: arXiv
Year: 2014
Subjects: subject: Systems and Control (eess.SY)
subject: Optimization and Control (math.OC)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Mathematics

description: Much has been said about observability in system theory and control; however, it has been recently that observability in complex networks has seriously attracted the attention of researchers. This paper examines the state-of-the-art and discusses some issues raised due to "complexity" and "stochasticity". These unresolved issues call for a new practical methodology. For stochastic systems, a degree of observability may be defined and the observability problem is not a binary (i.e., yes-no) question anymore. Here, we propose to employ a goal-seeking system to play a supervisory role in the network. Hence, improving the degree of observability would be a valid objective for the supervisory system. Towards this goal, the supervisor dynamically optimizes the observation process by reconfiguring the sensory parts in the network. A cognitive dynamic system is suggested as a proper choice for the supervisory system. In this framework, the network itself is viewed as the environment with which the cognitive dynamic system interacts. Computer experiments confirm the potential of the proposed approach for addressing some of the issues raised in networks due to complexity and stochasticity.
description: Submitted to IEEE Trans. Network Science and Engineering on October 25, 2014
Time to Cannulation after ICU Admission Increases Mortality for Patients Requiring Veno-Venous ECMO for COVID-19 Associated Acute Respiratory Distress Syndrome
Creators: name: Raff, Lauren A.
name: Gallaher, Jared R.
name: Raff, Evan J.
name: Reid, Trista S.
name: Johnson, Daniel
name: Charles, Anthony G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: Objective: COVID-19 can cause acute respiratory distress syndrome (ARDS) that is rapidly progressive, severe, and refractory to conventional therapies. Extracorporeal membrane oxygenation (ECMO) can be used as a supportive therapy to improve outcomes but evidence-based guidelines have not been defined. Summary Background Data: Initial mortality rates associated with ECMO for ARDS in COVID-19 were high, leading some to believe that there was no role for ECMO in this viral illness. With more experience, outcomes have improved. The ideal candidate, timing of cannulation, and best post-cannulation management strategy, however, has not yet been defined.  Methods: We conducted a retrospective review from April 1 to July 31 2020 of the first 25 patients with COVID-19 associated ARDS placed on V-V ECMO at our institution. We analyzed the differences between survivors to hospital discharge and those who died. Modified Poisson regression was used to model adjusted risk factors for mortality.  Results: 44% of patients (11/25) survived to hospital discharge. Survivors were significantly younger (40.5 years vs. 53.1 years; p < 0.001) with no differences between cohorts in mean body mass index, diabetes, or PaO2:FiO2 at cannulation. Survivors had shorter duration from symptom onset to cannulation (12.5 days vs. 19.9 days, p = 0.028) and shorter duration of intensive care unit (ICU) length of stay (LOS) prior to cannulation (5.6 days vs. 11.7 days, p = 0.045). Each day from ICU admission to cannulation increased the adjusted risk of death by 4% and each year increase in age increased the adjusted risk 6%. Conclusions: ECMO has a role in severe, refractory ARDS associated with COVID-19. Increasing age and time from ICU admission were risk factors for mortality and should be considered in patient selection. Further studies are needed to define best practices for V-V ECMO use in COVID-19.
Distributed Power Control in Multiuser MIMO Networks with Optimal Linear Precoding
Creators: name: Siyari, Peyman
name: Aghaeinia, Hassan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Information Theory (cs.IT)
subject: Computer Science and Game Theory (cs.GT)
subject: FOS: Computer and information sciences

description: Contractive interference functions introduced by Feyzmahdavian et al. is the newest approach in the analysis and design of distributed power control laws. This approach can be extended to several cases of distributed power control. One of the distributed power control scenarios wherein the contractive interference functions have not been employed is the power control in MIMO systems. In this paper, this scenario will be analyzed. In addition, the optimal linear precoder is employed in each user to achieve maximum point-to-point information rate. In our approach, we use the same amount of signaling as the previous methods did. However, we show that the uniqueness of Nash equilibria is more probable in our approach, suggesting that our proposed method improves the convergence performance of distributed power control in MIMO systems. We also show that the proposed power control algorithm can be implemented asynchronously, which gives a noticeable flexibility to our algorithm given the practical communication limitations.
description: 6 pages, 3 figures, Presented in 7th International Symposium on Telecommunications (IST 2014)
Additional file 2 of Macrophages coordinate immune response to laser-induced injury via extracellular traps
Creators: name: Conedera, Federica M.
name: Kokona, Despina
name: Zinkernagel, Martin S.
name: Stein, Jens V.
name: Lin, Charles P.
name: Alt, Clemens
name: Enzmann, Volker
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 2: Fig. S1. Association between the clustering of macrophages/monocytes with parenchymal and vascular damage. Spearman's rank-order correlation between damaged (Injury, top) and the area of fluorescein leakage (BRB break, bottom) with the number of macrophages/monocytes (LysMGFP) and neutrophils (LysMGFP/Ly6G+) clustering in the injury in untreated mice. Color intensity and the size of the circle are proportional to the correlation coefficients, and a star (*) marks significant correlation.
Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study
Creators: name: Phillips, L.S.
name: Dimos, S.F.
name: Rich, S.S.
name: Tao, R.
name: Below, J.E.
name: Darst, B.F.
name: Bien, S.A.
name: Correa, A.
name: Buyske, S.
name: Polikowsky, H.G.
name: Haiman, C.A.
name: Hu, Y.
name: Carlson, C.S.
name: Armstrong, N.D.
name: Polfus, L.M.
name: North, K.E.
name: Matise, T.C.
name: Rasmussen-Torvik, L.J.F.
name: Wojcik, G.L.
name: Highland, H.M.
name: Loos, R.J.F.
name: Pankow, J.S.
name: Avery, C.L.
name: Graff, M.
name: Rotter, J.I.
name: Wang, Y.
name: Kooperberg, C.
name: Liu, S.
name: Irvin, M.R.
name: Downie, C.G.
name: Raffield, L.M.
Publisher: name: Springer Science and Business Media Deutschland GmbH
Year: 2022

description: Aims/hypothesis: Type 2 diabetes is a growing global public health challenge. Investigating quantitative traits, including fasting glucose, fasting insulin and HbA1c, that serve as early markers of type 2 diabetes progression may lead to a deeper understanding of the genetic aetiology of type 2 diabetes development. Previous genome-wide association studies (GWAS) have identified over 500 loci associated with type 2 diabetes, glycaemic traits and insulin-related traits. However, most of these findings were based only on populations of European ancestry. To address this research gap, we examined the genetic basis of fasting glucose, fasting insulin and HbA1c in participants of the diverse Population Architecture using Genomics and Epidemiology (PAGE) Study. Methods: We conducted a GWAS of fasting glucose (n = 52,267), fasting insulin (n = 48,395) and HbA1c (n = 23,357) in participants without diabetes from the diverse PAGE Study (23% self-reported African American, 46% Hispanic/Latino, 40% European, 4% Asian, 3% Native Hawaiian, 0.8% Native American), performing transethnic and population-specific GWAS meta-analyses, followed by fine-mapping to identify and characterise novel loci and independent secondary signals in known loci. Results: Four novel associations were identified (p < 5 × 10−9), including three loci associated with fasting insulin, and a novel, low-frequency African American-specific locus associated with fasting glucose. Additionally, seven secondary signals were identified, including novel independent secondary signals for fasting glucose at the known GCK locus and for fasting insulin at the known PPP1R3B locus in transethnic meta-analysis. Conclusions/interpretation: Our findings provide new insights into the genetic architecture of glycaemic traits and highlight the continued importance of conducting genetic studies in diverse populations. Data availability: Full summary statistics from each of the population-specific and transethnic results are available at NHGRI-EBI GWAS catalog (https://www.ebi.ac.uk/gwas/downloads/summary-statistics).
The separator of a subset of a semigroup
Creators: name: Nagy, Attila
Publisher: name: arXiv
Year: 2015
Subjects: subject: Group Theory (math.GR)
subject: FOS: Mathematics

description: In this paper we introduce a new notion by the help of the idealizer. This new notion is the separator of a subset of a semigroup. We investigate the properties of the separator in an arbitrary semigroup and characterize the unitary subsemigroups and the prime ideals by the help of their separator. The last section of this paper treats the separator of a free subsemigroup of a free semigroup.
description: 6 pages
Agroecology, Supply Chains, and COVID-19: Lessons on Food System Transitions from Ecuador
Creators: name: Havice, E.
name: Lyall, A.
name: Colloredo-Mansfeld, R.
name: Vallejo, F.
Publisher: name: John Wiley and Sons Inc
Year: 2021

description: In cities, agroecological food consumption is often identified as an exclusive, middle-class practice. In this article, we examine changes in agroecological food circuits in urban Ecuador, amid COVID-19 breakdowns in conventional food systems. Through interviews with farmers, government officials, and NGO workers in 2020 and 2021, our research identifies three sets of experiences with distinct implications for agroecological transitions. First, some agroecological circuits could no longer function due to regulations on food circulation that favored the corporate food sector. Second, some circuits temporarily expanded to reach more urban middle-class consumers, using online platforms and government infrastructures. Third, urban collectives and neighborhood organizations re-appropriated urban spaces – from cultural centers to city streets – to facilitate the circulation of agroecological foods in low-income sectors. We highlight the spatial and social ‘re-localization’ practices of these urban groups that challenge the hegemony of conventional food circuits, as they drive agroecological food consumption beyond the middle-class.
Die Relevanz der Sprache bei Gewaltpräventionsprogrammen an Primarschulen
Creators: name: Cimander, Carina
Publisher: name: Zenodo
Year: 2021
Subjects: Logopädie
Sprachentwicklungsstörung
Gewalt
Gewaltprävention
Primarschule
Bachelorarbeit

description: Kinder mit Sprachentwicklungsstörungen neigen eher zu Gewalt und externalisierenden Verhaltensweisen als ihre sprachunauffälligen Mitschüler_innen (z.B. Wang, Aarø & Ystrom, 2018). Es ist daher unerlässlich, dass Kinder mit reduzierten kommunikativen Kompetenzen von Gewaltpräventionsprogrammen, wie sie derzeit in Primarschulen in der Schweiz durchgeführt werden, profitieren können (Müller & Sigrist, 2019). Es besteht allerdings häufig die Problematik, dass Anwender_innen die Inhalte von Gewaltpräventionsprogrammen nur schwer vermitteln können, wenn die Kinder über wenig Sprache verfügen (Fraas & Deyringer-Köhler, 2014). Diese Arbeit verfolgt daher die Hypothese, dass Gewaltpräventionsprogramme in ihrer Anwendung sprachlich komplex und anspruchsvoll sind und folglich Kinder mit Sprachentwicklungsstörungen überfordert werden. Die sprachlichen Einschränkungen bei Kindern mit Sprachentwicklungsstörungen und die Anforderungen der drei gängigen Gewaltpräventionsprogramme Chili, Peacemaker und Faustlos, wurden analysiert und auf Übereinstimmungen hin untersucht. Abschliessend wurde anhand dieser Datenlage eines der Gewaltpräventionsprogramme favorisiert, welches für Kinder mit einer Sprachentwicklungsstörung in Bezug auf Methodenvielfalt und handlungsorientiertem Lernen, den grössten Erfolg verspricht.
Split Boot -- True Network-Based Booting on Heterogeneous MPSoCs
Creators: name: Fuchs, Marvin
name: Ardila-Perez, Luis E.
name: Mehner, Torben
name: Sander, Oliver
Publisher: name: arXiv
Year: 2023
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Systems and Control (eess.SY)
subject: FOS: Physical sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In the context of the High-Luminosity (HL) upgrade of the LHC, many custom ATCA electronics boards are being designed containing heterogeneous System-on-Chip (SoC) devices, more specifically the Xilinx Zynq UltraScale+ (ZUS+) family. While the application varies greatly, these devices are regularly used for performing board management tasks, making them a fundamental element in the correct operation of the board. The large number of hundreds of SoC devices creates significant challenges in their firmware deployment, maintenance, and accessibility. Even though U-Boot on ZUS+ devices supports network boot through the Preboot Execution Environment (PXE), the standard ZUS+ boot process contains application-specific information at earlier boot steps, particularly within the First Stage Bootloader (FSBL). This prevents the initialization of several devices from a universal image. Inspired by the PXE boot process on desktop PCs, this paper describes split boot, a novel boot method tailored to the specific needs of the ZUS+. All application-specific configuration is moved to a network storage device and automatically fetched during the boot process. We considered the entire process, from firmware and software development to binary distribution in a large-scale system. The developed method nicely integrates with the standard Xilinx development toolset workflow.
description: 7 pages, double-column, 7 figures, 2 tables. Paper submitted as proceeding for the 23rd IEEE Real Time Conference (2022)
Digital divide, craft firms’ websites and urban-rural disparities—empirical evidence from a web-scraping approach; [Digital Divide, Websites von Handwerksunternehmen und städtisch-ländliche Disparitäten – empirische Erkenntnisse aus einer Web-Scraping Analyse]
Creators: name: Thonipara, Anita
name: Sternberg, Rolf
name: Proeger, Till
name: Haefner, Lukas
Publisher: name: Berlin ; Heidelberg : Springer
Year: 2022
Subjects: subject: Digital divide
subject: Digitalization
subject: Rural
subject: Small and Medium-Sized Enterprises
subject: Urban
subject: Web-scraping
subject: Dewey Decimal Classification::900 | Geschichte und Geografie::910 | Geografie, Reisen

description: Following the “death of distance” postulate, digitalization may reduce or even eliminate the penalty of firms being located in rural areas compared with those in urban agglomerations. Despite many recent attempts to measure digitalization effects across space, there remains a lack of empirical evidence regarding the adoption of digital technologies from an explicit spatial perspective. Using web-scraping data for a sample of 345,000 small firms in Germany, we analyze the determinants of website prevalence. Comparing urban with rural areas, we show that running a website—as a proxy for the degree of digitalization of the respective firm—is highly dependent on location, whereby firms in urban areas are almost twice as likely to run websites compared with those located in rural areas. Our county-level analysis shows that a high population density, a young population and a high educational level have a positive and significant association with the probability that firms run websites. Surprisingly, we find a negative and significant association of gross domestic product per capita with website prevalence, which is driven by urban regions. There are no differences between urban, semi-urban and rural areas in terms of website up-to-dateness as well as social media prevalence. We conclude that there is a substantial digital divide and discuss policy implications.
title: ИЗУЧЕНИЕ МИКРОБИОТЫ КАК ФАКТОРА РАЗВИТИЯ АЛЛЕРГИИ
Creators: name: Нора, С.
name: Архипов, Г.
name: Кропачев, И.
name: Никитина, Н.
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2020

description: В данном исследовании предлагается изучить влияние микробиоты на развитие и течение аллергических заболеваний. Аллергии – социально значимая проблема, оказывающая значительное влияние на качество жизни и экономику в целом. В исследовании планируется изучить несколько групп испытуемых (всего 200 испытуемых), имеющих аллергические заболевания. При изучении влияния микробиоты на развитие и
течение аллергии следует учитывать и дополнительные параметры (иммуногенетические, иммунологические). По результатам научно-исследовательского проекта будут выявлены микроорганизмы, оказывающие наибольшее влияние на развитие и течение аллергии, а также будут разработаны рекомендации по диагностике и лечению аллергических заболеваний.
Factors associated with Intensified Infection Prevention and Vaccination Practice among Thai Healthcare Personnel: A Multicenter survey during COVID-19 pandemic
Creators: name: Sathitakorn, Ornnicha
name: Jantarathaneewat, Kittiya
name: Weber, David J
name: Warren, David K
name: Apisarnthanarak, Anucha
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: Intensified infection prevention (IP) and healthcare personnel (HCP) vaccination programs could enhance HCP safety during COVID-19 pandemic. A multi-center survey regarding on intensified IP practices and vaccination uptake among HCP was performed. Working in the emergency medicine department was associated with wearing a double mask and face shield (p=0.04). Despite having more confidence in care of COVID-19 patients, there was no significant improvement of intensified IP practices, COVID-19 and influenza vaccination programs among “high-risk” HCP.
C-Band All-Sky Survey: A First Look at the Galaxy
Creators: name: Irfan, M. O.
name: Dickinson, C.
name: Davies, R. D.
name: Copley, C.
name: Davis, R. J.
name: Ferreira, P. G.
name: Holler, C. M.
name: Jonas, J. L.
name: Jones, Michael E.
name: King, O. G.
name: Leahy, J. P.
name: Leech, J.
name: Leitch, E. M.
name: Muchovej, S. J. C.
name: Pearson, T. J.
name: Peel, M. W.
name: Readhead, A. C. S.
name: Stevenson, M. A.
name: Sutton, D.
name: Taylor, Angela C.
name: Zuntz, J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present an analysis of the diffuse emission at 5 GHz in the first quadrant of the Galactic plane using two months of preliminary intensity data taken with the C-Band All Sky Survey (C-BASS) northern instrument at the Owens Valley Radio Observatory, California. Combining C-BASS maps with ancillary data to make temperature-temperature plots we find synchrotron spectral indices of $β= -2.65 \pm 0.05$ between 0.408 GHz and 5 GHz and $ β= -2.72 \pm 0.09$ between 1.420 GHz and 5 GHz for $-10^{\circ} < |b| < -4^{\circ}$, $20^{\circ} < l < 40^{\circ}$. Through the subtraction of a radio recombination line (RRL) free-free template we determine the synchrotron spectral index in the Galactic plane ($ |b| < 4^{\circ}$) to be $β= -2.56 \pm 0.07$ between 0.408 GHz and 5 GHz, with a contribution of $53 \pm 8$ per cent from free-free emission at 5\,GHz. These results are consistent with previous low frequency measurements in the Galactic plane. By including C-BASS data in spectral fits we demonstrate the presence of anomalous microwave emission (AME) associated with the HII complexes W43, W44 and W47 near 30 GHz, at 4.4 sigma, 3.1 sigma and 2.5 sigma respectively. The CORNISH VLA 5 GHz source catalogue rules out the possibility that the excess emission detected around 30\;GHz may be due to ultra-compact HII regions. Diffuse AME was also identified at a 4 sigma level within $30^{\circ} < l < 40^{\circ}$, $-2^{\circ} < b < 2^{\circ}$ between 5 GHz and 22.8 GHz.
description: 16 pages, 9 figures, submitted to MNRAS, referee's corrections made, awaiting for final approval for publication
A novel constraint-tightening approach for robust data-driven predictive control
Creators: name: Klöppelt, Christian
name: Berberich, Julian
name: Allgöwer, Frank
name: Müller, Matthias A.
Publisher: name: New York, NY [u.a.] : Wiley
Year: 2022
Subjects: subject: data-driven MPC
subject: robust MPC
subject: Dewey Decimal Classification::500 | Naturwissenschaften::510 | Mathematik
subject: Dewey Decimal Classification::600 | Technik::620 | Ingenieurwissenschaften und Maschinenbau

description: In this paper, we present a data-driven model predictive control (MPC) scheme that is capable of stabilizing unknown linear time-invariant systems under the influence of process disturbances. To this end, Willems' lemma is used to predict the future behavior of the system. This allows the entire scheme to be set up using only a priori measured data and knowledge of an upper bound on the system order. First, we develop a state-feedback MPC scheme, based on input-state data, which guarantees closed-loop practical exponential stability and recursive feasibility as well as closed-loop constraint satisfaction. The scheme is extended by a suitable constraint tightening, which can also be constructed using only data. In order to control a priori unstable systems, the presented scheme contains a prestabilizing controller and an associated input constraint tightening. We first present the proposed data-driven MPC scheme for the case of full state measurements, and also provide extensions for obtaining similar closed-loop guarantees in case of output feedback. The presented scheme is applied to a numerical example.
Additional file 3 of Macrophages coordinate immune response to laser-induced injury via extracellular traps
Creators: name: Conedera, Federica M.
name: Kokona, Despina
name: Zinkernagel, Martin S.
name: Stein, Jens V.
name: Lin, Charles P.
name: Alt, Clemens
name: Enzmann, Volker
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 3: Fig. S2. Absence of ETosis in neutrophils during injury response in the retina. Transmission electron microscopy showing a neutrophil in the retinal tissue and no of ET formation was observed. This cell displays various granules in the cytoplasm, along with a lobulated nucleus. The condensed heterochromatin (dark) is positioned at the nucleus's edge, interrupted by euchromatic areas near nuclear pores. The brighter euchromatin is predominantly located in the center of the lobules.
Unveiling pseudospin and angular momentum in photonic graphene
Creators: name: Song, Daohong
name: Paltoglou, Vassilis
name: Liu, Sheng
name: Zhu, Yi
name: Gallardo, Daniel
name: Tang, Liqin
name: Xu, Jingjun
name: Ablowitz, Mark
name: Efremidis, Nikolaos K.
name: Chen, Zhigang
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Pseudospin, an additional degree of freedom inherent in graphene, plays a key role in understanding many fundamental phenomena such as the anomalous quantum Hall effect, electron chirality and Klein paradox. Unlike the electron spin, the pseudospin was traditionally considered as an unmeasurable quantity, immune to Stern-Gerlach-type experiments. Recently, however, it has been suggested that graphene pseudospin is a real angular momentum that might manifest itself as an observable quantity, but so far direct tests of such a momentum remained unfruitful. Here, by selective excitation of two sublattices of an artificial photonic graphene, we demonstrate pseudospin-mediated vortex generation and topological charge flipping in otherwise uniform optical beams with Bloch momentum traversing through the Dirac points. Corroborated by numerical solutions of the linear massless Dirac-Weyl equation, we show that pseudospin can turn into orbital angular momentum completely, thus upholding the belief that pseudospin is not merely for theoretical elegance but rather physically measurable.
description: 12 pages, 5 figures