cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Investigating the interaction of the PKB PH domain with inositol phosphate-based compounds
Creators: name: Rosen, Sarah Ann Jacqueline
Publisher: name: Imperial College London
Year: 2013

description: Protein kinase B (PKB) plays a key role in the phosphoinositide 3-kinase pathway, one of the most frequently activated proliferation pathways in cancer. A key stage in this pathway is PKB’s translocation to the plasma membrane, which is driven by direct interaction of PKB’s pleckstrin homology (PH) domain with the inositol phosphate head-groups of phosphoinositide lipids PtdIns(3,4,5)P3 and PtdIns(3,4)P2. In this thesis a computational approach has been applied to study the interaction between PKB’s PH domain and the inositol phosphate head-groups of phosphoinositide lipids. Herein the first full set of parameters for these inositol phosphates has been generated using a clearly defined algorithmic approach. The parameters have been applied in a total of 6 μs of molecular dynamics (MD) simulations to investigate the interaction between inositol phosphates and the PKB PH domain. The simulations successfully mirror, and additionally rationalise, PKB’s experimental interactions and behaviour. As well as investigating the native system, a PKB mutant that has been reported in multiple human cancers has also been explored. This PKB mutant constitutively targets the plasma membrane due to its broadened phosphoinositide selectivity. The atomic-level view available from MD simulations has helped elucidate the molecular mechanism behind this. Information obtained about the PKB PH domain’s binding interface has been used to design inositol phosphate derivatives to inhibit PKB activation. MD simulations have allowed a number of inositol phosphate derivatives to be rapidly screened for their inhibitory behaviour. The predicted behaviour of a select number of these derivatives has been further assessed using biochemical techniques. Gratifyingly, the computational and biochemical results are shown to be in good agreement.
Supersymmetric gauged U(1)$_{L_μ-L_τ}$ model for neutrinos and the muon $(g-2)$ anomaly
Creators: name: Banerjee, Heerak
name: Byakti, Pritibhajan
name: Roy, Sourov
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The gauged $U(1)_{L_μ-L_τ}$ model can provide for additional contributions to the muon anomalous magnetic moment by means of a loop involving the $Z^{\prime}$ gauge boson. However, the parameter space of such models is severely constrained if one combines the latest muon $(g-2)$ data with various neutrino experiments, such as neutrino trident production, $ν-e$ and $ν-q$ elastic scattering, etc. In a supersymmetric $U(1)_{L_μ-L_τ}$ model, a larger region of parameter space opens up, thus enabling one to explore otherwise forbidden regions of parameter space in nonsupersymmetric models involving the new gauge coupling ($g_X$) and the mass of the $Z^\prime$ gauge boson ($M_{Z^{\prime}}$) . We show that the minimal model with the minimal supersymmetric Standard Model (MSSM) field content is strongly disfavored from $Z$-boson decay and neutrino data. We also show that the nonminimal model with two extra singlet superfields can lead to correct neutrino masses and mixing involving both tree-level and one-loop contributions. We find that, in this model, both muon $(g-2)$ and neutrino data may be simultaneously explained in a parameter region consistent with experimental observations. In addition, we observe that the muon $(g-2)$ anomaly can be accommodated even with higher values of electroweak sparticle masses compared to the MSSM. Charged lepton-flavor-violating processes (like $μ\rightarrow eγ$, $τ\rightarrow μγ$, etc.) may have potentially large branching ratios in this scenario. Depending on the magnitude of the supersymmetry contribution to these processes, they may constrain hitherto unconstrained regions of the $M_{Z^{\prime}}-g_X$ parameter space. However, we find that these branching fractions never exceed their upper bounds in a region where both muon $(g-2)$ and neutrino oscillation data can be simultaneously accommodated.
description: v2: 25 pages, 9 figures. Discussion on charged lepton-flavor-violating processes $l_j\rightarrow l_i\gamma$ added in the text. Appendix C added on the same. References added. Published Version
A Study of Two Diffuse Dwarf Galaxies in the Field
Creators: name: Greco, Johnny P.
name: Goulding, Andy D.
name: Greene, Jenny E.
name: Strauss, Michael A.
name: Huang, Song
name: Kim, Ji Hoon
name: Komiyama, Yutaka
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present optical long-slit spectroscopy and far-ultraviolet to near-infrared spectral energy distribution fitting of two diffuse dwarf galaxies, LSBG-285 and LSBG-750, which were recently discovered by the Hyper Suprime-Cam Subaru Strategic Program (HSC-SSP). We measure redshifts using H$α$ line emission, and find that these galaxies are at comoving distances of ${\approx}25$ and ${\approx}41$ Mpc, respectively, after correcting for the local velocity field. They have effective radii of $r_\mathrm{eff}=1.2$ and 1.8 kpc and stellar masses of $M_\star\approx2$-$3\times10^{7}~M_\odot$. There are no massive galaxies ($M_\star>10^{10} M_\odot$) within a comoving separation of at least 1.5 Mpc from LSBG-285 and 2 Mpc from LSBG-750. These sources are similar in size and surface brightness to ultra-diffuse galaxies, except they are isolated, star-forming objects that were optically selected in an environmentally blind survey. Both galaxies likely have low stellar metallicities $[Z_\star/Z_\odot] < -1.0$ and are consistent with the stellar mass-metallicity relation for dwarf galaxies. We set an upper limit on LSBG-750's rotational velocity of ${\sim}50$ km s$^{-1}$, which is comparable to dwarf galaxies of similar stellar mass with estimated halo masses $<10^{11}~M_\odot$. We find tentative evidence that the gas-phase metallicities in both of these diffuse systems are high for their stellar mass, though a statistically complete, optically-selected galaxy sample at very low surface brightness will be necessary to place these results into context with the higher-surface-brightness galaxy population.
description: 16 pages, 6 figures; accepted for publication in ApJ
Pseudofinite H-structures and groups definable in supersimple H-structures
Creators: name: Zou, Tingxiang
Publisher: name: arXiv
Year: 2018
Subjects: subject: Logic (math.LO)
subject: FOS: Mathematics

description: In this paper we explore some properties of H-structures. We describe a construction of H-structures based on one-dimensional asymptotic classes which preserves pseudo-finiteness. That is, the H-structures we construct are ultraproducts of finite structures. We also prove that under the assumption that the base theory is supersimple of SU-rank one, there are no new definable groups in H-structures.
The $q$-Borel Sum of Divergent Basic Hypergeometric Series ${}_rφ_s(a;b;q,x)$
Creators: name: Adachi, Shunya
Publisher: name: arXiv
Year: 2018
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: 33D15, 39A13, 34M30

description: We study the divergent basic hypergeometric series which is a $q$-analog of divergent hypergeometric series. This series formally satisfies the linear $q$-difference equation. In this paper, for that equation, we give an actual solution which admits basic hypergeometric series as a $q$-Gevrey asymptotic expansion. Such an actual solution is obtained by using $q$-Borel summability, which is a $q$-analog of Borel summability. Our result shows a $q$-analog of the Stokes phenomenon. Additionally, we show that letting $q\to1$ in our result gives the Borel sum of classical hypergeometric series. The same problem was already considered by Dreyfus, but we note that our result is remarkably different from his one.
Reverberation Mapping and the Disk Wind Model of the Broad Line Region
Creators: name: Chiang, J.
name: Murray, N.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Using the disk wind model of Murray et al. (1995), we calculate line profiles and frequency-resolved response functions for broad line emission from the surface of an accretion disk in an AGN in the presence of a radiatively driven wind. We find that the combined effects of the shears in the wind and in the disk itself produce anisotropic line emission which solves several well-known problems connected with disk models of the broad line region. In particular, the broadening of resonance lines such as \Civ, \Lya, and \Nv\/ can be attributed to orbital motion of the disk gas at radii as close as $\sim 10^{16}$~cm in Seyferts without requiring unrealistically large emission regions in order to produce single-peaked profiles. Furthermore, the anisotropy of the line emission results in frequency-dependent response functions which are no longer red-blue symmetric so that the time delays inferred for the various red and blue components of the line agree qualitatively with recent reverberation mapping observations of NGC~5548.
description: 17 pages text, 8 postscript figures
Two distinguishable impurities in BEC: squeezing and entanglement of two Bose polarons
Creators: name: Charalambous, C.
name: Garcia-March, M. A.
name: Lampo, A.
name: Mehboudi, M.
name: Lewenstein, M.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We study entanglement and squeezing of two uncoupled impurities immersed in a Bose-Einstein condensate. We treat them as two quantum Brownian particles interacting with a bath composed of the Bogoliubov modes of the condensate. The Langevin-like quantum stochastic equations derived exhibit memory effects. We study two scenarios: (i) In the absence of an external potential, we observe sudden death of entanglement; (ii) In the presence of an external harmonic potential, entanglement survives even at the asymptotic time limit. Our study considers experimentally tunable parameters.
description: 38 pages, 7 figures
Biomimetic total synthesis of resorcylate natural products via a decarboxylative, allyl migration and aromatisation sequence
Creators: name: Anderson, Katie Elizabeth
Publisher: name: Imperial College London
Year: 2013

description: Angelico in A (I), angelicoin B (II), cristatic acid (III) and grifolic acid (IV) (Figure A1) are members of the resorcylate family of natural products which contain a common 6-alkyl-2,4-dihydroxy benzoic acid core (β-resorcylate unit). The total syntheses of angelicoin A (I) and angelicoin B (II) from 2,2,6-trimethyl-4H-1,3-dioxin-4-one V are reported using late stage aromatisation reactions via diketo-dioxinones as advanced intermediates. In the case of angelicoin A (I), biomimetic aromatisation was coupled with a highly regioselective palladium(0)-catalysed decarboxylative prenyl migration as the key step (Scheme A1).(a)(b) The palladium(0)-catalysed decarboxylative, prenylation and aromatisation sequence furnished both linear VII and branched adducts VI. Extensive optimisation of conditions to improve the ratio of linear to branched adducts involved the screening of palladium catalysts, ligands, solvents, reactions times, temperature and organic and inorganic bases.(a)(c) The regioselectivity of this novel palladium(0)- catalysed decarboxylative prenyl migration was determined unambiguously through X-ray crystallographic studies.(a)(c) Furthermore, an intermolecular mechanism is proposed after thorough mechanistic studies including cross over and variable concentration experiments, base studies and regioselectivity investigations. Two synthetic approaches towards the total synthesis of cristatic acid methyl ester are reported. The first approach investigated a one-pot reaction to install the furan moiety VIII (Scheme A2), via a Nef reaction, deprotection, decarboxylation and furan formation. The second approach attempted to perform a one-pot Pd(0)-decarboxylative allylation, TMSE deprotection and aromisation to provide the core of cristatic acid IX (Scheme A3). Finally, studies towards the total synthesis of grifolic acid (IV) are reported utilising the palladium(0)-catalysed decarboxylative allyl migration and aromatisation sequence.
Cuculus vetula Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Cuculiformes
Cuculidae
Cuculus
Cuculus vetula

description: Cuculus vetula [spec. nov.]
C. cauda cuneiformi, corpore subfusco: subtus testaceo, ciliis rubris.
Cuculus major. Sloan. jam. 2. p. 312. t. 258. f. 1, 2.
Cuculus major olivaceus, cauda longiore, ciliis rubris. Brown. jam. 476.
Picus major leucophaeus s. canescens, pluviae avis & Senex dictus. Raj. av. 182.
Habitat in Jamaica.
Voce clamosiore pluviam praesagit.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 111, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
The oxidative stability of FAME in the model Crankcase environment
Creators: name: Hall, James
Publisher: name: Imperial College London
Year: 2012

description: The use of biodiesel has increased in recent years due to the implementation of governmental policies driven by environmental, economic and political reasons. Biodiesel is composed of fatty acid methyl esters (FAME), which can be derived from plant, marine and animal sources. There have been reports of some potential problems associated with biodiesel use in modern diesel engines, with lubricant dilution by blended biodiesel fuels leading to accumulation of FAME in the oil sump in the crankcase. This project focuses on the design and implementation of an experimental model based on the Rancimat apparatus that can simulate certain aspects of the FAME degradation chemistry occurring in the crankcase and oil sump. An analysis procedure to compliment the experimental model is applied to carry out product distribution analysis on a series of (C18) model FAME, identifying and quantifying the oxidation products formed under the experimental conditions, where epoxides are the major monomeric degradation. Some oxidation kinetic parameters have been investigated using biodiesel samples, with noticeable differences in oxidation rates found when FAME are oxidised individually and when in mixtures. Kinetic factors of FAME and model base oil in single and multi-component systems have also been investigated, with the base oil displaying good oxidative stability in mixtures as well as on its own The influence of antioxidants on stabilising various model systems has shown synergistic effects. Combinations of primary and secondary antioxidants have displayed good synergy, with the suppression of the rate of hydroperoxide formation by primary antioxidants enhancing the effectiveness of the secondary antioxidant. Primary antioxidants have been observed to affect the onset of oxidation, whilst secondary antioxidants decrease the hydroperoxide and epoxide, but increase the alcohol yields as a result of autoxidation.
title: ADCO, Premier cartulaire de Saint-Étienne de Dijon (XIIe siècle), Cart. 21 (G 125), 71 folios, f. 00065
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2015
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Premier cartulaire de Saint-Étienne de Dijon (XIIe siècle), Archives départementales de la Côte-d'Or, Cart. 21 (G 125), 71 folios, f. 00065, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Premier cartulaire de Saint-Étienne de Dijon (XIIe siècle), Archives départementales de la Côte-d'Or, Cart. 21 (G 125), 71 folios, f. 00065, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Additional file 1 of Knowledge, health beliefs and attitudes towards dementia and dementia risk reduction among descendants of people with dementia: a qualitative study using focus group discussions
Creators: name: Vrijsen, J.
name: Maeckelberghe, E. L. M.
name: Broekstra, R.
name: de Vries, J. J.
name: Abu-Hanna, A.
name: De Deyn, P. P.
name: Voshaar, R. C. Oude
name: Reesink, F. E.
name: Buskens, E.
name: de Rooij, S. E.
name: Smidt, N.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Supplementary Table 1. Focus group topics and illustrative questions. Supplementary file 2. Definitions of low, middle, and high level of education based on the International Standard Classification of Education.
You Shall Not Pass: Warning Drivers of Unsafe Overtaking Maneuvers on Country Roads by Predicting Safe Sight Distance
Creators: name: Bauske, Adrian
name: Fleig, Arthur
Publisher: name: arXiv
Year: 2025
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences
subject: H.5.2

description: Overtaking on country roads with possible opposing traffic is a dangerous maneuver and many proposed assistant systems assume car-to-car communication and sensors currently unavailable in cars. To overcome this limitation, we develop an assistant that uses simple in-car sensors to predict the required sight distance for safe overtaking. Our models predict this from vehicle speeds, accelerations, and 3D map data. In a user study with a Virtual Reality driving simulator (N=25), we compare two UI variants (monitoring-focused vs scheduling-focused). The results reveal that both UIs enable more patient driving and thus increase overall driving safety. While the monitoring-focused UI achieves higher System Usability Score and distracts drivers less, the preferred UI depends on personal preference. Driving data shows predictions were off at times. We investigate and discuss this in a comparison of our models to actual driving behavior and identify crucial model parameters and assumptions that significantly improve model predictions.
description: 23 pages, 27 figures, 2 tables, ACM CHI 2025
title: ADCO, Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.1 (début XIIIe siècle), Cart. 166 (11 H 64), 136 folios, f. 0000-001
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.1 (début XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 166 (11 H 64), 136 folios, f. 0000-001, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.1 (début XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 166 (11 H 64), 136 folios, f. 0000-001, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: abbaye de Cîteaux
Ultra-low voltage electrowetting
Creators: name: Cousens, Nico
Publisher: name: Imperial College London
Year: 2012

description: Electrowetting, the manipulation of surface wettability with an electric field, is an emerging technology used in next generation displays and cameras. This has been made possible by the development of ‘electrowetting -on- die lectric’ by Berge in 1993. Howev er, such a system operates on large voltages poorly suited to portable devices. In recent years, theoretical and experimental results have suggested that electrowetting using the interface between two immiscible electrolyte solutions (ITIES) may provide a solution to this problem. By applying less than 1 V to such a system, it is possible to induce substantial changes in the wettability — and hence the shape — of liquid droplets. However, there is a large degree of hysteresis in such a system meaning that there is a poor correlation between droplet shape and applied potential. Furthermore, the stability of the ITIES over long periods is of concern. This thesis attempts to address the current problems with ITIES electrowetting highlighted above. By moving to smoother and more lubricated surfaces, a substantial reduction in hysteresis was seen. These surfaces were produced by template stripping. In addition, several other surfaces were prepared as potential electrowetting substrates. These involved surface functionalisation by plasma treatment or the reduction of diazonium compounds; preparation of ultra smooth glassy carbon and preparation of a hydrophobic conducting polymer. The potential range over which an ITIES is stable was also improved with the use of a novel mixed organic solvent phase. By optimising the electrode and electrolyte compositions, an electrowetting system operating on less than 1 V with a contact angle range of 53 o and a gap of only 100 mV between forward and reverse scans was possible. Other electrowetting systems with no hysteresis were also developed, although these did not operate within the potential limits defined by the onset of Faradaic processes.
Graph Operations on Zero-Divisor Graph of Posets
Creators: name: N. Hosseinzadeh
Publisher: name: figshare
Year: 2018
Subjects: subject: 10104 Combinatorics and Discrete Mathematics (excl. Physical Combinatorics)
subject: FOS: Mathematics

description: We know that some large graphs can be constructed from some smaller graphs by using graphs operations. Many properties of such large graphs are closely related to those of the corresponding smaller ones. In this paper we investigate some operations of zero-divisor graph of posets.
Additional file 1 of Global incidence and prevalence of idiopathic pulmonary fibrosis
Creators: name: Maher, Toby M.
name: Bendstrup, Elisabeth
name: Dron, Louis
name: Langley, Jonathan
name: Smith, Gerald
name: Khalid, Javaria Mona
name: Patel, Haridarshan
name: Kreuter, Michael
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Additional file 1: Table S1. PICO search criteria. Table S2. Model-associated adjustments for prevalence estimates adjusted per country. Table S3. Included studies and associated IPF categories. Table S4. List of studies for IPF incidence estimates. Table S5. List of studies for IPF prevalence estimates (primary analysis).
An almost cyclic 2-coordinate descent method for singly linearly constrained problems
Creators: name: Cristofari, Andrea
Publisher: name: arXiv
Year: 2018
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics
subject: 90C06, 90C30, 65K05

description: A block decomposition method is proposed for minimizing a (possibly non-convex) continuously differentiable function subject to one linear equality constraint and simple bounds on the variables. The proposed method iteratively selects a pair of coordinates according to an almost cyclic strategy that does not use first-order information, allowing us not to compute the whole gradient of the objective function during the algorithm. Using first-order search directions to update each pair of coordinates, global convergence to stationary points is established for different choices of the stepsize under an appropriate assumption on the level set. In particular, both inexact and exact line search strategies are analyzed. Further, linear convergence rate is proved under standard additional assumptions. Numerical results are finally provided to show the effectiveness of the proposed method.
description: Computational Optimization and Applications
Exploring novel regimes for ion acceleration driven by intense laser radiation
Creators: name: Dover, Nicholas
Publisher: name: Imperial College London
Year: 2013

description: This thesis covers experimental and numerical studies on novel schemes of ion accelera- tion with high intensity lasers. In particular, it discusses previously unexplored regimes incorporating the radiation pressure of intense lasers. These schemes are of interest to potential applications due to the emergence of improved ion beam properties that are detailed in this thesis. The thesis discusses results from ion acceleration experiments using intense optical lasers on ultra-thin targets at the Rutherford Appleton Laboratory, where the Vulcan Petawatt system was used to irradiate nanometre thickness foils. In particular, the accelerated proton beam profiles from these interactions showed a variety of features, such as Rayleigh-Taylor-like instability driven spatial beam modulation, annular rings and a high-energy tail. A particularly interesting novel observation is the emergence of a spectrally peaked on-axis component to the proton beam, which is indicative of buffering of the proton layer ahead of a heating heavier ion species. These different features will be analysed and discussed, and modelled using PIC simulation. The thesis also includes the results from recent experiments studying the interaction of an intense CO2 laser with an overdense plasma generated by a gas jet. A remarkably monoenergetic proton beam was measured, in contrast to the majority of experiments performed previously on ion acceleration, and was found by optical probing and numer- ical simulation to be a result of hole-boring generated by the radiation pressure of the intense laser pulse acting on the plasma. The thesis will include analysis of interferom- etry and shadowgraphy images of the plasma, and discussion of the plasma dynamics and ion generation mechanisms involved, including the generation of radiation pressure driven collisionless shock waves. The effects of the laser prepulse, electron transport effects and non-linear post-soliton production will all be discussed. It will also present detailed numerical particle-in-cell (PIC) simulation of the interaction.
Finslerian Hypersurfaces and Quartic Change of Finsler Metric
Creators: name: Gauree Shanker
name: Ramdayal Singh Kushwaha
Publisher: name: figshare
Year: 2018
Subjects: subject: 10104 Combinatorics and Discrete Mathematics (excl. Physical Combinatorics)
subject: FOS: Mathematics

description: In the present paper we have studied the Finslerian hypersurfaces and quartic change of a Finsler metric. The relationship with Finslerian hypersurface and the other which is finslerian hypersurface given by quartic change have been obtained. We have also proved that quartic change makes three type of hyper surfaces invarient under certain condition. These three type of hyper surfaces are hyperplanes of first, second, and third kind.
Additional file 1 of Physiotherapists’ use and perceptions of digital remote physiotherapy during COVID-19 lockdown in Switzerland: an online cross-sectional survey
Creators: name: Rausch, Anne-Kathrin
name: Baur, Heiner
name: Reicherzer, Leah
name: Wirz, Markus
name: Keller, Fabienne
name: Opsommer, Emmanuelle
name: Schoeb, Veronika
name: Vercelli, Stefano
name: Barbero, Marco
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1.
Relation between millimeter wavelengths emission and high-energy emission for active galactic nuclei
Creators: name: Huang, L. H.
name: Jiang, D. R.
name: Cao, Xinwu
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: After comparing the flux densities of a sample of active galactic nuclei detected by energetic gamma-ray experiment telescope at 90 and 230 GHz with the $γ$-ray emissions detected by Compton Gamma Ray Observatory and x-ray emission, a strong correlation between the emissions at the millimeter wavelength and the $γ$-ray emission is found. The average flux density of x-ray is almost proportional to the average flux density at the millimeter wavelength for quasars detected by energetic gamma-ray experiment telescope, which strongly supports the previous idea that the x-ray emissions of this kind sources are mainly produced by Synchrotron Self-Compton process.
description: 6 pages, Chinese Physics Letters in press
Solar Corona Heating by the Axion Quark Nugget Dark Matter
Creators: name: Raza, Nayyer
name: van Waerbeke, Ludovic
name: Zhitnitsky, Ariel
Publisher: name: arXiv
Year: 2018
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this work we advocate for the idea that two seemingly unrelated 80-year-old mysteries - the nature of dark matter and the high temperature of the million degree solar corona - may have resolutions that lie within the same physical framework. The current paradigm is that the corona is heated by nanoflares, which were originally proposed as miniature versions of the observed solar flares. It was recently suggested that the nanoflares could be identified as annihilation events of the nuggets from the Axion Quark Nugget (AQN) dark matter model. This model was invented as an explanation of the observed ratio $Ω_{\rm dark} \sim Ω_{\rm visible}$, based only on cosmological and particle physics considerations. In this new paradigm, the AQN particles moving through the coronal plasma and annihilating with normal matter can lead to the drastic change of temperatures seen in the Sun's Transition Region (TR), and significantly contribute to the extreme ultraviolet (EUV) excess of $10^{27}~{\rm erg~s^{-1}}$. To test this proposal, we perform numerical simulations with a realistically modeled AQN particle distribution and explore how the nuggets interact with the coronal plasma. Remarkably, our simulations predict the correct energy budget for the solar corona, and show that the energy injection mostly occurs at an altitude of around 2000 km, which is where the TR lies. Therefore, we propose that these long unresolved mysteries could be two sides of the same coin. We make several predictions based on this proposal, some of which could be tested by the recently launched NASA mission, the Parker Solar Probe.
description: 28 pages, 10 figures, Accepted by Physical Review D
Cuculus glandarius Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Cuculiformes
Cuculidae
Cuculus
Cuculus glandarius

description: Cuculus glandarius [spec. nov.]
C. cauda cuneiformi, capite subcristato, fascia oculari nigra.
Cuculus fulvus maculatus. Edw. av. 57. t. 57.
Habitat in Africa septentrionali & Europa australi.
Dorsum fuscum. Alae albo punctatae. Subtus testaceus est. Caput cinereum, subcristatum. Linea nigra trans oculos.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 111, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
The Gravitational Force Field of the Galaxy Measured From the Kinematics of RR Lyrae in Gaia
Creators: name: Wegg, Christopher
name: Gerhard, Ortwin
name: Bieth, Marie
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: From a sample of 15651 RR Lyrae with accurate proper motions in Gaia DR2, we measure the azimuthally averaged kinematics of the inner stellar halo between 1.5 kpc and 20 kpc from the Galactic centre. We find that their kinematics are strongly radially anisotropic, and their velocity ellipsoid nearly spherically aligned over this volume. Only in the inner regions $\lesssim$ 5 kpc does the anisotropy significantly fall (but still with $β>$ 0.25) and the velocity ellipsoid tilt towards cylindrical alignment. In the inner regions, our sample of halo stars rotates at up to 50 km s$^{-1}$, which may reflect the early history of the Milky Way, although there is also significant angular momentum exchange with the Galactic bar at these radii. We subsequently apply the Jeans equations to these kinematic measurements in order to non-parametrically infer the azimuthally averaged gravitational acceleration field over this volume, and by removing the contribution from baryonic matter, measure the contribution from dark matter. We find that the gravitational potential of the dark matter is nearly spherical with average flattening $q_Φ=$ 1.01 $\pm$ 0.06 between 5 kpc and 20 kpc, and by fitting parametric ellipsoidal density profiles to the acceleration field, we measure the flattening of the dark matter halo over these radii to be $q_ρ=$ 1.00 $\pm$ 0.09.
description: Accepted for publication in MNRAS
Equitable Coloring on Triple Star Graph Families
Creators: name: K. Praveena
name: M. Venkatachalam
Publisher: name: figshare
Year: 2018
Subjects: Algebra

description: An equitable k-coloring of a graph G is a proper k-coloring of G such that the sizes of any two color class differ by at most one. In this paper we investigate the equitable chromatic number for the Central graph, Middle graph, Total graph and Line graph of Triple star graph.
The Cluster Abundance in Flat and Open Cosmologies
Creators: name: Viana, Pedro T P
name: Liddle, Andrew R
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We use the galaxy cluster X-ray temperature distribution function to constrain the amplitude of the power spectrum of density inhomogeneities on the scale corresponding to clusters. We carry out the analysis for critical density universes, for low density universes with a cosmological constant included to restore spatial flatness and for genuinely open universes. That clusters with the same present temperature but different formation times have different virial masses is included. We model cluster mergers using two completely different approaches, and show that the final results from each are extremely similar. We give careful consideration to the uncertainties involved, carrying out a Monte Carlo analysis to determine the cumulative errors. For critical density our result agrees with previous papers, but we believe the result carries a larger uncertainty. For low density universes, either flat or open, the required amplitude of the power spectrum increases as the density is decreased. If all the dark matter is taken to be cold, then the cluster abundance constraint remains compatible with both galaxy correlation data and the {\it COBE} measurement of microwave background anisotropies for any reasonable density.
description: Uuencoded package containing LaTeX file (uses mn.sty) plus 7 postscript figures incorporated using epsf. Total length 10 pages. Final version, to appear MNRAS. COBE comparison changed to 4yr data. No change to results or conclusions
Picosecond imaging of dynamics of solvated electrons during femtosecond laser-induced plasma generation in water
Creators: name: Sakakibara, Noritaka
name: Ito, Tsuyohito
name: Hakuta, Yukiya
name: Shimizu, Yoshiki
name: Terashima, Kazuo
name: Miura, Eisuke
Publisher: name: arXiv
Year: 2025
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: The dynamics of solvated electrons were visualized using absorption imaging with sub-picosecond time resolution based on a pump-probe measurement during the early stages of femtosecond laser-induced plasma generation in water. The solvated electrons were generated by the propagation of a femtosecond laser pump pulse. In the area with a pump laser intensity over 2x10^13 W/cm2, where a high density of free electrons was produced, solvated electrons exhibited an additional rapid increase in optical density (OD) at 800 nm, 7-9 ps after the pump pulse excitation. In contrast, no two-step increase in OD was observed when probed at 400 nm, suggesting that the absorption coefficient of the solvated electrons rapidly changed around 800 nm after femtosecond laser excitation for a few picoseconds. This observation might indicate the structural and electronic modulation of solvated electrons owing to the high density of free electrons in water, accompanied by femtosecond-laser-induced plasma generation.
description: 25 pages, 7 figures
An investigation Into the function, accuracy and technology associated with arthroplasty of the hip
Creators: name: Aqil, Adeel
Publisher: name: Imperial College London
Year: 2016

description: Hip arthroplasty is a successful intervention for symptomatic end stage arthritis of the hip. However it remains an imperfect procedure due in many respects to the difficulty in reproducing biomechanics for each individual patient. Reproduction of femoral offset and leg length ensures appropriate muscle balancing which allows for hip biomechanics to be restored. In addition adequate soft tissue balancing reduces the risk of complications such as dislocations and nerve injuries. Post- operative functional performance may also be affected by the implant technology being used as well as surgical accuracy. However little is known as to what functional performance is to be expected following hip arthroplasty, especially when function is measured at fast speeds and walking inclines. This thesis will explore the gait of patients prospectively through pre to post-operative stages, in an attempt to ascertain what gait changes can be expected following hip arthroplasty. Furthermore the gait assessments will focus on higher end function, when walking at fast speeds. Following this, this thesis aims to assess whether gait differences are evident when different implants are used, and judge whether they may be a functional advantage to using different implants in hip reconstruction. Surgical accuracy is paramount, when avoiding complications alluded to earlier. This thesis explores whether rapid prototyping technology can be utilised to aid accurate insertion a femoral stem as part of a pre-clinical test. Finally this thesis will also test the association of implant size and failures that has been alluded to from national joint registries.
Extended Quasi Conformal Curvature Tensor on N(k)-Contact Metric Manifold
Creators: name: R.T. Naveen Kumar
name: H. Aruna Kumara
Publisher: name: figshare
Year: 2018
Subjects: subject: 10104 Combinatorics and Discrete Mathematics (excl. Physical Combinatorics)
subject: FOS: Mathematics

description: In this paper certain results on N(k)-contact metric manifold endowed with a extended quasi conformal curvature tensor are formulated.
Gaussian tight binding study of ultrafast electron dynamics
Creators: name: Boleininger, Max
Publisher: name: Imperial College London
Year: 2017

description: Computer simulations are invaluable for the study of ultrafast phenomena, as it is not possible to directly access the electronic and nuclear dynamics in experiments. We present an efficient method for simulating the time-dependent coupled electron-ion dynamics within the Ehrenfest picture in molecules under the influence of time-dependent electric fields, based on an extension of the density-functional tight binding model. We consider self-consistency in a self-multipole-consistent framework, expanding the electron density in terms of radial Gaussian and angular real cubic harmonic functions. This enables the efficient computation of the electrostatic interaction energy while retaining a physical description of charge transfer and ionic polarisation. We show that this Gaussian tight binding method produces molecular polarisabilities, time-dependent dipole moments, and electron densities in strong agreement with density-functional theory, but at a small fraction of the cost. This efficiency enables high-throughput ultrafast studies on molecules, which we demonstrate on the example of transient core-spectroscopy on polythiophene fragments.
The IL-17 family in paediatric severe therapy resistant asthma
Creators: name: Adams, Alexandra
Publisher: name: Imperial College London
Year: 2017

description: Paediatric asthma has traditionally been considered a T Helper 2 (TH2) cell mediated disease with the TH2 cytokines interleukin (IL)-4, IL-5 and IL-13 promoting eosinophilic airway inflammation, hyper-responsiveness and remodelling. In the majority of patients airway inflammation can be well controlled with low dose inhaled corticosteroids. There is however a small group in whom control is not achieved despite high dose corticosteroids, these children have severe therapy resistant asthma (STRA). Previous work in paediatric STRA showed a relative absence of the TH2 cytokines in the airways, but preliminary data identified raised levels of IL-17. Elevated IL-17 has been associated with severe asthma in adults, but its role in children was unknown. The overarching hypothesis of this work is paediatric STRA is mediated by the IL-17 family of cytokines and this is the mechanism resulting in steroid resistant and persistent airway inflammation. Children undergoing clinically indicated bronchoscopy were recruited to the study. Broncho-alveolar lavage, endobronchial biopsies, bronchial epithelial brushings and peripheral blood were collected from STRA children and results were compared to a disease control group, undergoing bronchoscopy for recurrent respiratory infections, as a positive control group previously shown to have TH-17 activation. Flow cytometry protocols were developed to identify IL-17A producing cells (TH17, gamma delta T cells and innate lymphoid cells) in BAL. ELISA and bead based multiplex were used to measure cytokines in the BAL, endobronchial biopsies were stained for IL-17 and primary human bronchial epithelial cells were cultured and stimulated in the presence of budesonide to investigate the mechanisms of steroid resistance in vitro. As found in previous work, TH2 mediators (IL-4, IL-5 and IL-13) were not raised in STRA children. Contrary to one of the hypotheses of this thesis, neither IL-17 producing T cells nor IL-17A were elevated in the airways of STRA children. 16 HBE cells (human bronchial epithelial cell line) were cultured and stimulated with IL-17A and/or budesonide and secretion of IL-6 and IL-8 was measured to develop the steroid resistance protocol. Subsequently, primary bronchial epithelial cells from STRA children and controls were cultured and shown to demonstrate steroid resistant properties and behave significantly differently to 16HBE cells. I have confirmed that the TH2 related cytokines were not raised in children with STRA. Although IL-17A was associated with increased steroid resistance, levels were not increased in STRA compared to disease controls. These data suggest IL-17A is not responsible for the persistent airway inflammation in this group treated with high doses of corticosteroids. The role of IL-17A in mediating paediatric STRA is therefore less certain than in adult severe disease.
Cuculus scolopaceus Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Cuculiformes
Cuculidae
Cuculus
Cuculus scolopaceus

description: Cuculus scolopaceus [spec. nov.]
C. cauda cuneiformi, corpore undique griseo fuscoque nebuloso.
Cuculus indicus fuscus maculatus. Edw. av. 59. t. 59.
Habitat in Benghala.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 111, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Semiclassical and quantum behavior of the Mixmaster model in the polymer approach for the isotropic Misner variable
Creators: name: Crinò, Chiara
name: Montani, Giovanni
name: Pintaudi, Giorgio
Publisher: name: arXiv
Year: 2018
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We analyze the semiclassical and quantum behavior of the Bianchi IX Universe in the Polymer Quantum Mechanics framework, applied to the isotropic Misner variable, linked to the space volume of the model. The study is performed both in the Hamiltonian and field equations approaches, leading to the surprising result of a still singular and chaotic cosmology, whose Poincaré return map asymptotically overlaps the standard Belinskii-Khalatnikov-Lifshitz one. In the quantum sector, we reproduce the original analysis due to Misner, within the revised Polymer approach and we arrive to demonstrate that the quantum numbers of the point-Universe still remain constants of motion. This issue confirms the possibility to have quasi-classical states up to the initial singularity. The present study clearly demonstrates that the asymptotic behavior of the Bianchi IX Universe towards the singularity is not significantly affected by the Polymer reformulation of the spatial volume dynamics both on a pure quantum and a semiclassical level.
description: 25 pages, 10 figures. v2: more discussions/clarification added
Even Modular Edge Irregularity Strength of Graphs
Creators: name: K. Muthugurupackiam
name: S. Ramya
Publisher: name: figshare
Year: 2018
Subjects: subject: 10104 Combinatorics and Discrete Mathematics (excl. Physical Combinatorics)
subject: FOS: Mathematics

description: A new graph characteristic, even modular edge irregularity strength of graphs is introduced. Estimation on this parameter is obtained and the precise values of this parameter are obtained for some families of graphs.
Additional file 2 of Physiotherapists’ use and perceptions of digital remote physiotherapy during COVID-19 lockdown in Switzerland: an online cross-sectional survey
Creators: name: Rausch, Anne-Kathrin
name: Baur, Heiner
name: Reicherzer, Leah
name: Wirz, Markus
name: Keller, Fabienne
name: Opsommer, Emmanuelle
name: Schoeb, Veronika
name: Vercelli, Stefano
name: Barbero, Marco
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 2.