Biologically active oxovanadium(IV) Schiff base metal complex: antibacterial, antioxidant, biomolecular interaction and molecular docking studies
Creators: name: Gurusamy, Shunmugasundaram
name: Sankarganesh, Murugesan
name: Asha, Radhakrishnan Nandini
name: Mathavan, Alagarsamy
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: The oxovanadium(IV) Schiff base metal complex (ISNPV) have been synthesized as well as characterized by using micro analytical and traditional spectroscopic techniques. The spectral findings were utilized to validate the formation of ISNPV with structure exhibited square pyramidal geometry. The <i>in vitro</i> antibacterial activities of ISNPV were investigated to five different bacterial stains such as <i>S. aureus</i>, <i>S. epidermidis</i>, <i>B. cereus</i>, <i>B. amyloliquefaciens</i> and <i>B. subtilis</i>. The obtained result have suggested that the ISNPV has highest antibacterial activity against <i>S. aureus</i> than the other bacterial stains. The <i>in vitro</i> antioxidant activity like DPPH free radical scavenging assay method was studied by ISNPV in DMSO medium. Because it scavenges all free radicals, the ISNPV possesses higher antioxidant activity than the free ligand. UV-visible absorption and emission spectral techniques were used to investigate the binding of CT-DNA to the ISNPV. Both the spectral data indicate that the ISNPV binds the double helix structure of CT-DNA via an intercalation mode. Additionally, investigate the interactions of ISNPV with the protein molecules like BSA/HAS has been investigated using absorption and emission techniques. The absorption intensity of metal complex increases as well as the emission intensity of protein molecules ability decreases due to the binding nature of ISNPV with BSA/HSA protein molecules. The binding nature of ISNPV with bio molecules such as CT-DNA, BSA and HSA was also validated using molecular docking approach. HighlightsThe oxovanadium(IV) Schiff base metal complex (ISNPV) were synthesized and analyzed by various spectral approaches.The moderate antibacterial activities of ISNPV than free ligand.The ISNPV has excellent DPPH free radical scavenging activities.The interactions of ISNPV with CT-DNA, BSA and HSA were evaluated by using UV-visible absorption and emission spectral methods.The nature of interaction of ISNPV with biomolecules was also validated by molecular docking methods. The oxovanadium(IV) Schiff base metal complex (ISNPV) were synthesized and analyzed by various spectral approaches. The moderate antibacterial activities of ISNPV than free ligand. The ISNPV has excellent DPPH free radical scavenging activities. The interactions of ISNPV with CT-DNA, BSA and HSA were evaluated by using UV-visible absorption and emission spectral methods. The nature of interaction of ISNPV with biomolecules was also validated by molecular docking methods. Communicated by Ramaswamy H. Sarma