cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
All-optical generation of Abrikosov vortices by the Inverse Faraday Effect
Creators: name: Plastovets, V. D.
name: Tokman, I. D.
name: Lounis, B.
name: Mel'nikov, A. S.
name: Buzdin, A. I.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Within the framework of the time-dependent Ginzburg-Landau theory we show that circularly polarized THz or far-infrared radiation induces a dc supercurrent that influences the dynamics of vortex-antivortex pair formation in a mesoscopic superconductor undergoing rapid thermal quenching. The Lorentz force arising from the supercurrents promotes vortex-antivortex separation and allows survival of the vortex polarity defined by the helicity of light. Based on this idea, we propose a two-stage irradiation scheme that provides a powerful method for controlled all-optical generation of Abrikosov vortices.
title: Axillary Musculoskeletal Fibromatosis: Diagnostic interpretation, imaging follow up and patient review
Creators: name: Motupally, Karun
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2022
Subjects: subject: Musculoskeletal soft tissue
subject: Oncology
subject: MR
subject: Imaging sequences
subject: Neoplasia

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: We introduce two patients who share the common diagnosis of axillary musculoskeletal fibromatosis. We explore the initial presentation, circumstances leading to diagnosis, imaging characteristics and treatment options. Desmoid tumours are rare...
Validation of Picture Free and Cued Selective Reminding Test for Illiteracy in Lima, Peru
Creators: name: Custodio, N.
name: Soto, A.
name: Montesinos, R.
name: Delgado, C.
name: Parodi, J.F.
name: Diaz, M.M.
name: Slachevsky, A.
name: Valeriano-Lorenzo, E.
name: Herrera-Perez, E.
Publisher: name: SAGE Publications Ltd
Year: 2022

description: Dementia in Latin America is a crucial public health problem. Identifying brief cognitive screening (BCS) tools for the primary care setting is crucial, particularly for illiterate individuals. We evaluated tool performance characteristics and validated the free and total recall sections of the Free and Cued Selective Reminding Test-Picture version (FCSRT-Picture) to discriminate between 63 patients with early Alzheimer?s disease dementia (ADD), 60 amnestic mild cognitive impairment (aMCI) and 64 cognitively healthy Peruvian individuals with illiteracy from an urban area. Clinical, functional, and cognitive assessments were performed. FCSRT-Picture performance was assessed using receiver operating characteristic curve analyses. The mean ± standard deviation scores were 7.7 ± 1.0 in ADD, 11.8 ± 1.6 in aMCI, and 29.5 ± 1.8 in controls. The FCSRT-Picture had better performance characteristics for distinguishing controls from aMCI compared with several other BCS tools, but similar characteristics between controls and early ADD. The FCSRT-Picture is a reliable BCS tool for illiteracy in Peru.
Spectral density of the Dirac operator in two-flavour QCD
Creators: name: Engel, Georg P.
name: Giusti, Leonardo
name: Lottini, Stefano
name: Sommer, Rainer
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We compute the spectral density of the (Hermitean) Dirac operator in Quantum Chromodynamics with two light degenerate quarks near the origin. We use CLS/ALPHA lattices generated with two flavours of O(a)-improved Wilson fermions corresponding to pseudoscalar meson masses down to 190 MeV, and with spacings in the range 0.05-0.08 fm. Thanks to the coverage of parameter space, we can extrapolate our data to the chiral and continuum limits with confidence. The results show that the spectral density at the origin is non-zero because the low modes of the Dirac operator do condense as expected in the Banks-Casher mechanism. Within errors, the spectral density turns out to be a constant function up to eigenvalues of approximately 80 MeV. Its value agrees with the one extracted from the Gell-Mann-Oakes-Renner relation.
Differential rotation and radiative equilibrium in the Sun: is the tachocline spreading?
Creators: name: Caleo, Andrea
name: Balbus, Steven
name: Potter, William
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: It is well known that the combination of barotropic rotation and radiative equilibrium are mutually incompatible in stars. The Sun's internal rotation is far from barotropic, however, which allows at least the theoretical possibility that the Sun's thermal balance is one of radiative equilibrium in the region of the tachocline near the outer boundary of the radiative zone. We show here that (i) the constraint of radiative equilibrium leads to a straightforward ordinary differential equation for the Sun's rotation profile, and (ii) solutions of this equation can be found that, to within current levels of accuracy, closely resemble the rotation profile deduced from helioseismology. More generally, we calculate how large a baroclinic deviation from uniform rotation is required to maintain radiative equilibrium without meridional circulation throughout the bulk of the radiative zone. Very little deviation is required, well below detectability. The feasibility of radiative equilibrium for the tachocline suggests that the issue of a spreading boundary layer may be less severe than previously thought.
title: The Utilisation of Balloon Catheters in Interventional Radiology: A case series
Creators: name: Ward, Adam
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2022
Subjects: subject: Interventional non-vascular
subject: Interventional vascular
subject: Catheter arteriography
subject: Catheter venography
subject: Fluoroscopy
subject: Angioplasty
subject: Balloon occlusion
subject: Catheters
subject: Education and training
subject: Other

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: To review cases at our interventional radiology department involving conventional and non-conventional use of balloon catheters and to illustrate the versatility and utility of balloon catheter...
Additional file 12 of Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer’s disease
Creators: name: Vandermeulen, Lina
name: Geric, Ivana
name: Fumagalli, Laura
name: Kreir, Mohamed
name: Lu, Ashley
name: Nonneman, Annelies
name: Premereur, Jessie
name: Wolfs, Leen
name: Policarpo, Rafaela
name: Fattorelli, Nicola
name: De Bondt, An
name: Van Den Wyngaert, Ilse
name: Asselbergh, Bob
name: Fiers, Mark
name: De Strooper, Bart
name: d’Ydewalle, Constantin
name: Mancuso, Renzo
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Virology

description: Additional file 12 Supplemental Fig. 1. ASO screening cascade and primer design.
Gas and stars in the Teacup quasar looking with the 6-m telescope
Creators: name: Moiseev, Alexei V.
name: Ikhsanova, Alina I.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: New results on the radio-quiet type 2 quasar known as the Teacup galaxy (SDSSJ1430+1339) based on the long-slit and 3D spectroscopic data obtained at the Russian 6-m telescope are presented. The ionized gas giant nebula extending up to r=56 kpc in the [O III] emission line was mapped with the scanning Fabry-Perot interferometer. The direct estimation of the emission line ratios confirmed that the giant nebula is ionized by the AGN. Stars in the inner r<5 kpc are significantly younger than the outer host galaxy and have a solar metallicity. The central starburst age (~1 Gyr) agrees with possible ages for the galactic merger events and the previous episode of the quasar outflow produced two symmetric arcs visible in the [O III[ emission at the distances r=50-55 kpc. The ionized gas velocity field can be fitted by the model of a circular rotating disk significantly inclined or even polar to the stellar host galaxy.
description: 11 pages, 6 figures, 1 table. The final version accepted to Universe
Current strategies and findings in clinically relevant post-translational modification-specific proteomics
Creators: name: Pagel, Oliver
name: Loroch, Stefan
name: Sickmann, Albert
name: Zahedi, René P.
Publisher: name: Milton Park : Taylor & Francis
Year: 2015
Subjects: subject: biomarkers
subject: clinical proteomics
subject: degradomics
subject: ERLIC
subject: glycoproteomics
subject: LC-MS
subject: phosphoproteomics
subject: PTM
subject: quantification
subject: 570

description: Mass spectrometry-based proteomics has considerably extended our knowledge about the occurrence and dynamics of protein post-translational modifications (PTMs). So far, quantitative proteomics has been mainly used to study PTM regulation in cell culture models, providing new insights into the role of aberrant PTM patterns in human disease. However, continuous technological and methodical developments have paved the way for an increasing number of PTM-specific proteomic studies using clinical samples, often limited in sample amount. Thus, quantitative proteomics holds a great potential to discover, validate and accurately quantify biomarkers in body fluids and primary tissues. A major effort will be to improve the complete integration of robust but sensitive proteomics technology to clinical environments. Here, we discuss PTMs that are relevant for clinical research, with a focus on phosphorylation, glycosylation and proteolytic cleavage; furthermore, we give an overview on the current developments and novel findings in mass spectrometry-based PTM research.
Michel De Waele, L’affirmation du fait colonial dans les relations internationales. La guerre franco-anglaise de 1627–1629, Rennes (Presses universitaires de Rennes) 2022
Creators: name: Bechtold, Jonas
Publisher: name: Francia-Recensio
Year: 2023

description: Michel De Waele, L’affirmation du fait colonial dans les relations internationales. La guerre franco-anglaise de 1627–1629, Rennes (Presses universitaires de Rennes) 2022, 328 p. (Histoire), ISBN 978-2-7535-8305-4, EUR 28,00.
description: Francia-Recensio, 2023/1
title: A single centre 7-year experience of IVC filter retrieval: retrieval rates and factors associated with retrieval
Creators: name: Ward, Adam
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2022
Subjects: subject: Interventional vascular
subject: Catheter venography
subject: Conventional radiography
subject: Filter insertions
subject: Other
subject: Education and training
subject: Embolism / Thrombosis

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: The advent of retrievable IVC filters was practice changing 1 ; Less than 10 years after their development reports were emerging in the literature that IVC filter use was increasing dramatically, 2,3 that clinical use and indication was highly...
title: Dynamic MRI in neurogenic thoracic outlet syndrome: Experience of a tertiary Australia hospital
Creators: name: Pugh, Liam
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2022
Subjects: subject: Musculoskeletal system
subject: Neuroradiology peripheral nerve
subject: MR
subject: Imaging sequences
subject: Other

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Thoracic outlet syndrome (TOS) consists of upper limb neurological and vascular symptoms due to compression of the neurovascular bundle as it passes through the thoracic outlet 1 . Compression may occur within the interscalene space, the...
A linear decomposition attack
Creators: name: Roman'kov, Vitaliǐ
name: Myasnikov, Alexei
Publisher: name: arXiv
Year: 2014
Subjects: subject: Group Theory (math.GR)
subject: FOS: Mathematics
subject: 20F10

description: We discuss a new attack, termed a dimension or linear decomposition attack, on several known group-based cryptosystems. This attack gives a polynomial time deterministic algorithm that recovers the secret shared key from the public data in all this schemes under consideration. Furthemore, we show that in this case, contrary to the common opinion, the typical computational security assumptions are not very relevant to the security of the schemes, i.e., one can break the schemes without solving the algorithmic problems on which the assumptions are based. The efficacy of the attack depends on the platform group, so it requires a more thorough analysis in each particular case.
title: Large hepatic cysts resulting in extrinsic compression of the inferior vena cava
Creators: name: Bairamian, Daniel
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2022
Subjects: subject: Abdomen
subject: Vascular
subject: Veins / Vena cava
subject: Catheter venography
subject: CT
subject: Drainage
subject: Cysts

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: We report an uncommon case of inferior vena cava (IVC) and portal vein obstruction due to large hepatic cysts, resulting in collateral azygos, hemiazygos and paralumbar venous drainage. A venogram of the IVC to exclude thrombosis was performed,...
Vascular Disease Patient Information Page: Livedoid vasculopathy
Creators: name: Moll, S.
name: Vedak, P.
name: Googe, P.
name: Eswaran, H.
Publisher: name: SAGE Publications Ltd
Year: 2022

description: What is livedoid vasculopathy (LV)? Livedoid vasculopathy, or LV, is a chronic skin condition characterized by small, painful sores that come and go over the legs and feet. ‘Livedoid’ refers to the bluish skin discoloration that often accompanies these sores. ‘Vasculopathy’ means a disease of the blood vessels. LV has been called different names such as livedoid vasculitis and atrophie blanche. LV is a rare disease, occurring in less than one in 100,000 people per year.
Lyke de Vries, Reformation, Revolution, Renovation. The Roots and Reception of the Rosicrucian Call for General Reform, Leiden (Brill Academic Publishers) 2021
Creators: name: Gard, Lennart
Publisher: name: Francia-Recensio
Year: 2023

description: Lyke de Vries, Reformation, Revolution, Renovation. The Roots and Reception of the Rosicrucian Call for General Reform, Leiden (Brill Academic Publishers) 2021, 444 p. (Universal Reform, 3), ISBN 978-90-04-25022-2, EUR 115,00.
description: Francia-Recensio, 2023/1
title:  A fabricação de uma forma pervertida de humano: Primo Levi e os rumores da memória
Creators: name: de Oliveira, Lucas Amaral
Publisher: name: Roma TrE-Press
Year: 2015

description: O químico e escritor Primo Levi construiu um dos testemunhos mais contundentes da segunda metade do século XX. Este texto tenta converter questões que aparecem em suas autobiografias mais impactantes sobre o campo de extermínio em problemas de caráter sociológico. Gostaria de interpretar seu testemunho como fonte documental, em que seja possível apreender aspectos informativos de denúncia da violência que assinou com sangue nossa era. Tentarei verificar os limites na construção do testemunho e as possibilidades encontradas pelo escritor na representação e reflexão sobre a experiência vivida; afinal, pensar a obra de Levi a partir de um conjunto de elementos que encontra na noção de memória seu eixo decisivo faz de seu testemunho não apenas um objeto de análise histórica, mas, ainda, fonte privilegiada para refletir sobre um desafio político: o imperativo sempre urgente de «não repetir o passado».
description: KRYPTON – VOL.5/6 – 2015 – VIOLENZA
title: Metastatic cutaneous SCC to the parotid: Adjuvant radiotherapy and treatment outcomes
Creators: name: Hu, Marcus
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2022
Subjects: subject: Head and neck
subject: Cone beam CT
subject: Radiation therapy / Oncology
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Squamous cell carcinoma (SCC) is the second most common cutaneous malignancy, and a rise in incidence of SCCs have been noted. The sun-exposed head and neck region is a common site for development of cutaneous SCC. Whilst the majority of patients...
title: Mechanism of Prion Protein (PrP) Degradation Induced by a Tetracationic-porphyrin: Implications for the Therapy of Prion Diseases
Creators: name: Masone, Antonio
Publisher: name: The Open University
Year: 2025

description: Prions are infectious agents responsible for deadly brain diseases. They consist of scrapie prion protein (PrPSc), a misfolded variant of the plasma membrane cellular prion protein (PrPC) which self-propagates by inducing misfolding of native PrPC. One of the multiple reasons that hampers the development of effective therapies, is that prions can adopt different pathogenic conformations (strains), which can be resistant to potential drugs, or acquire drug resistance during treatment. PrPC is the precursor and the substrate for the replication of any prion strain, and therefore represents the ideal target to abrogate prion generation and propagation in a strain-independent fashion. There is ample experimental evidence available that lowering PrPC is well tolerated and highly beneficial in prion disease, suggesting that targeting PrPC could be a promising therapeutic strategy.

 This thesis describes Zn(II)-BnPyP, a tetracationic porphyrin that binds to distinct domains of PrPC in a metal-dependent fashion, promoting PrPC degradation while inhibiting its conversion to PrPSc. Zn(II)-BnPyP binding to a C-terminal pocket destabilises the native PrPC fold, hindering conversion to PrPSc; Zn(II)-BnPyP binding to the flexible N-terminal tail disrupts N- to C-terminal interactions, triggering PrPC endocytosis and lysosomal degradation, thus reducing the substrate for PrPSc generation. With its bimodal action on the prion precursor protein, Zn(II)-BnPyP efficiently inhibits propagation of different prion strains in vitro, in neuronal cells and organotypic brain cultures, curing prion infection. These results identify a PrPC-targeting anti-prion compound with an unprecedented mechanism of action which should evade the problem of drug resistance.
Additional file 13 of Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer’s disease
Creators: name: Vandermeulen, Lina
name: Geric, Ivana
name: Fumagalli, Laura
name: Kreir, Mohamed
name: Lu, Ashley
name: Nonneman, Annelies
name: Premereur, Jessie
name: Wolfs, Leen
name: Policarpo, Rafaela
name: Fattorelli, Nicola
name: De Bondt, An
name: Van Den Wyngaert, Ilse
name: Asselbergh, Bob
name: Fiers, Mark
name: De Strooper, Bart
name: d’Ydewalle, Constantin
name: Mancuso, Renzo
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Virology

description: Additional file 13 Supplemental Fig. 2. Gating strategy for sorting xenotransplanted human and endogenous mouse microglia employing flow cytometry.
What Does Child Protective Services Investigate as Neglect? A Population-Based Study
Creators: name: Guo, Lillie
name: Font, Sarah
name: Palmer, Lindsey
name: Eastman, Andrea Lane
name: Putnam-Hornstein, Emily
Publisher: name: SAGE Publications Ltd
Year: 2022

description: Most child protective services (CPS) investigations involve allegations of neglect. Broad and vague definitions have led to concerns that CPS-investigated neglect is driven by poverty-based material hardship. In a representative sample of 295 neglect investigations in California in 2017, structured data and narrative text fields were used to characterize the types of neglect and concurrent parental risk factors investigated by CPS and to assess the rate and nature of investigated physical neglect, defined as inadequate food, housing, or hygiene. The most common types of neglect were inadequate supervision (44%) and failure to protect (29%), followed by physical neglect (14%). Common risk factors identified in neglect investigations were parental substance use (41%), domestic violence (21%), mental illness (18%), and co-reported physical or sexual abuse (29%). Nearly all investigations of physical neglect (99%) included concerns related to substance use, domestic violence, mental illness, co-reported abuse or an additional neglect allegation (i.e., abandonment). Given concerns identified in neglect investigations, economic supports are likely insufficient without an array of behavioral-health supports.
The analysis of realistic Stellar Gaia mock catalogues. I. Red Clump Stars as tracers of the central bar
Creators: name: Romero-Gomez, Merce
name: Figueras, Francesca
name: Antoja, Teresa
name: Abedi, Hoda
name: Aguilar, Luis
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: In this first paper we simulate the population of disc Red Clump stars to be observed by Gaia. We generate a set of test particles and we evolve it in a 3D barred Milky Way like galactic potential. We assign physical properties of the Red Clump trace population and a realistic 3D interstellar extinction model. We add Gaia observational constraints and an error model according to the pre-commissioning scientific performance assessments. We present and analyse two mock catalogues, offered to the community, that are an excellent test bed for testing tools being developed for the future scientific exploitation of Gaia data. The first catalogue contains stars up to Gaia G 20, while the second is the subset containing Gaia radial velocity data with a maximum error of sigmaVr=10 kms. Here we present first attempts to characterise the density structure of the Galactic bar in the Gaia space of observables. The Gaia large errors in parallax and the high interstellar extinction in the inner parts of the Galactic disc prevent us to model the bar overdensity. This result suggests the need to combine Gaia and IR data to undertake such studies. We find that IR photometric distances for this Gaia sample allow us to recover the Galactic bar orientation angle with an accuracy of approximately 5 degrees.
description: 16 pages, 17 figures, 2 tables. High resolution version available upon request to the running author. Accepted for publication in MNRAS
Evaluate underdiagnosis and overdiagnosis bias of deep learning model on primary open-angle glaucoma diagnosis in under-served patient populations
Creators: name: Lin, Mingquan
name: Xiao, Yuyun
name: Hou, Bojian
name: Wanyan, Tingyi
name: Sharma, Mohit Manoj
name: Wang, Zhangyang
name: Wang, Fei
name: Van Tassel, Sarah
name: Peng, Yifan
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: In the United States, primary open-angle glaucoma (POAG) is the leading cause of blindness, especially among African American and Hispanic individuals. Deep learning has been widely used to detect POAG using fundus images as its performance is comparable to or even surpasses diagnosis by clinicians. However, human bias in clinical diagnosis may be reflected and amplified in the widely-used deep learning models, thus impacting their performance. Biases may cause (1) underdiagnosis, increasing the risks of delayed or inadequate treatment, and (2) overdiagnosis, which may increase individuals' stress, fear, well-being, and unnecessary/costly treatment. In this study, we examined the underdiagnosis and overdiagnosis when applying deep learning in POAG detection based on the Ocular Hypertension Treatment Study (OHTS) from 22 centers across 16 states in the United States. Our results show that the widely-used deep learning model can underdiagnose or overdiagnose underserved populations. The most underdiagnosed group is female younger (< 60 yrs) group, and the most overdiagnosed group is Black older (>=60 yrs) group. Biased diagnosis through traditional deep learning methods may delay disease detection, treatment and create burdens among under-served populations, thereby, raising ethical concerns about using deep learning models in ophthalmology clinics.
description: 9 pages, 2 figures, Accepted by AMIA 2023 Informatics Summit
title: Post-market real-world data demonstrating use of an AI as an extra reader to augment breast cancer detection without unnecessary recalls
Creators: name: Nash, Jonathan
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2022
Subjects: subject: Breast
subject: Mammography
subject: Screening
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: The importance of breast screening programs is evident. However, mammography does have its limitations and a significant number of cancers are not detected in the regular screening round, but are diagnosed as interval cancers (IC) during follow-up...
A parameterization of low visibilities for hazy days in the North China Plain
Creators: name: Chen, J.
name: Zhao, C.S.
name: Ma, N.
name: Liu, P.F.
name: Göbel, T.
name: Hallbauer, E.
name: Deng, Z.Z.
name: Ran, L.
name: Xu, W.Y.
name: Liang, Z.
name: Liu, H.J.
name: Yan, P.
name: Zhou, X.J.
name: Wiedensohler, A.
Publisher: name: München : European Geopyhsical Union
Year: 2012
Subjects: subject: aerosol composition
subject: aerosol property
subject: concentration (composition)
subject: parameterization
subject: relative humidity
subject: sensitivity analysis
subject: size distribution
subject: visibility
subject: 550

description: Visibility degradation is a pervasive and urgent environmental problem in China. The occurrence of low visibility events is frequent in the North China Plain, where the aerosol loading is quite high and aerosols are strongly hygroscopic. A parameterization of light extinction (Kex) for low visibilities on hazy days is proposed in this paper, based on visibility, relative humidity (RH), aerosol hygroscopic growth factors and particle number size distributions measured during the Haze in China (HaChi) Project. Observational results show that a high aerosol volume concentration is responsible for low visibility at RH <90%; while for RH >90%, decrease of visibility is mainly influenced by the increase of RH. The parameterization of Kex is developed on the basis of aerosol volume concentrations and RH, taking into accounts the sensitivity of visibility to the two factors and the availability of corresponding data. The extinction coefficients calculated with the parameterization schemes agree well with the directly measured values.
Proaktive Gestaltung und Steuerung der Kultur in Bauvorhaben als Aufgabe des bauherrnseitigen Projektmanagements
Creators: name: John, Paul Christian
name: Schilling Miguel, Ana
Publisher: name: Universität Duisburg-Essen
Year: 2023
Subjects: Projektkultur
Projektmanagement
Bauherr
Projektabwicklung

description: Das Verhalten der Projektbeteiligten wird maßgeblich durch die Projektkultur geprägt. Entsprechend hängt auch der Erfolg einer Bauprojekts in hohem Maße von den Prägungen der entsprechenden Kultur ab. Ein angemessenes Kulturmanagement im Kontext der Baubranche fehlt jedoch trotz vielfach betonter Notwendigkeit bislang. In diesem Beitrag erläutern wir den (Projekt-)Kulturbegriff im organisationalen Kontext für ein besseres Verständnis dieses Phänomens. Darüber hinaus stellen wir bestehende Ansätze zur Gestaltung und Steuerung einer Kultur aus der Managementlehre vor. Eine Übertragung auf Bauprojekte ist jedoch nicht ohne weiteres möglich, da sich diese im Hinblick auf Kultur in einigen Aspekten maßgeblich von Unternehmen unterscheiden – entsprechende Herausforderungen werden diesbezüglich diskutiert. Auf Basis der Erkenntnisse schlagen wir ein Kulturmanagement vor. Dieses muss aufgrund der Rolle und Durchsetzungskompetenz Teil des bauherrnseitigen Projektmanagements sein. Hierzu werden erste denkbare Tätigkeitsfelder angesprochen. Kulturmanagement verspicht einen positiven Beitrag zu erfolgreichen Abwicklung von Bauvorhaben.
Association of IRS-1 and IRS-2 polymorphisms with predisposition to type-2 diabetes (T2D): a meta-analysis and trial sequential analysis
Creators: name: Luo, Qiaoyan
name: Ling, Zhifa
name: Huang, Xiaojia
name: Zuo, Ying
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Cancer

description: Background: Insulin Receptor Substrate (IRS) molecules play a major role in insulin signalling, and single nucleotide polymorphisms in the IRS-1 (rs1801278) and IRS-2 (rs1805097) gene has been associated with the predisposition to the development of type-2 diabetes (T2D) in some population. However, the observations remain contradictory. Discrepancies in the results have been attributed to several factors, and consideration of a smaller sample size is one of them. To reach a valid conclusion, we performed a meta-analysis of the genetic association between IRS-1 (rs1801278) and IRS-2 (rs1805097) polymorphism with a predisposition to T2D. Materials and Methods: The literature search was performed in different databases such as PubMed, Science Direct, and Scopus. All relevant articles were screened and based in inclusion and exclusion criteria eligible reports were identified. Baseline characteristics, genotype and allele frequencies were extracted from the eligible reports. The meta-analysis was performed by comprehensive meta-analysis software v3.3.070 and odds ratios, 95% confidence interval and probability values were calculated to find out association of IRS-1 and IRS-2 polymorphisms with rhinitis. Results: A total of seven studies comprising 1287 cases and 1638 control were considered for the present meta-analysis for the association of IRS-1 (rs1801278) polymorphism with T2D, and no significant association was observed. For IRS-2 (rs1805097) polymorphism, data from eight cohorts (cases: 1824, controls: 1786) were considered. The heterozygous genetic comparison models revealed a significant protective association against T2D predisposition (p = 0.017, OR = 0.841, 95% CI = 0.729 to 0.970). The trial sequential analysis revealed the requirement of additional case-control studies to draw a definitive conclusion for IRS-1 polymorphism. Conclusions: IRS-2 rs1805097 heterozygotes are protected from T2D development. However, IRS-1 (rs1801278) is not associated with a subject’s proclivity for T2D.
Investigation of GJB2 and SLC26A4 genes related to pendred syndrome genetic deafness patients.
Creators: name: Al-Zaidi, Haider Majid Haider
name: Mousavinasab, Fatemehsadat
name: Radseresht, Nika
name: Mirzaei, Alireza
name: Moradi, Yasaman
name: Mahmoudifar, Mohammad
Publisher: name: figshare
Year: 2023
Subjects: Bioinformatics and computational biology not elsewhere classified
Plant cell and molecular biology
Genetics not elsewhere classified
Gene expression (incl. microarray and other genome-wide approaches)
Agronomy

description: Deafness can occur due to damage to the ear, especially the inner ear. In other cases, the cause is a heterogeneous genetic abnormality and is caused by the changes that occur in the genes involved in the hearing process. Mutations in GJB2 and SLC26A4 genes are one of the most important causes of deafness in the world, which causes syndromic and non-syndromic hereditary hearing loss. The purpose of this study is to investigate GJB2 and SLC26A4 genes related to genetic syndromes of deafness and bioinformatic analysis at the genome and proteome level and to evaluate and compare the expression of these genes in different tissues of the human body. For this purpose, tools related to bioinformatics analysis such as UCSC and OMIM databases were used. One of the common genetic syndromes caused by mutations in these genes is pendred syndrome. The clinical symptoms of this disease are weight gain, constipation, dry skin, and hair, decreased energy, sleepiness, bulging belly, decreased body temperature, and slow growth. This disease does not currently have a specific treatment, so it is very important and fundamental to investigate the genetic factors affecting this disease. The results of this research showed that the transfer of potassium, sodium, and chlorine ions as well as the mutation in the SLC26A4 gene, which is responsible for the synthesis of pendrin protein, is very effective in the occurrence of pendred syndrome. To diagnose pendred syndrome more accurately, molecular methods should be used in genetic tests. The results of comparing the expression profiles of these two genes showed that the difference in the expression of these two genes is very high and, in general, the expression of the SLC26A4 gene in the body is very low. Because people with hearing loss have other problems including damage to other parts of the body such as the heart, kidneys, or eyes. Knowing the genetic cause in these cases allows the doctor to be aware of problems in other systems as well.
Additional file 14 of Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer’s disease
Creators: name: Vandermeulen, Lina
name: Geric, Ivana
name: Fumagalli, Laura
name: Kreir, Mohamed
name: Lu, Ashley
name: Nonneman, Annelies
name: Premereur, Jessie
name: Wolfs, Leen
name: Policarpo, Rafaela
name: Fattorelli, Nicola
name: De Bondt, An
name: Van Den Wyngaert, Ilse
name: Asselbergh, Bob
name: Fiers, Mark
name: De Strooper, Bart
name: d’Ydewalle, Constantin
name: Mancuso, Renzo
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Virology

description: Additional file 14 Supplemental Fig. 3. APOE and TREM2 ASO screening in THP-1 cells.
title: Инновации культурной жизни (на примере г. Волгограда)
Creators: name: Кобылкин, Роман
name: Медведева, Лариса
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2020

description: В статье проанализированы и обобщены новые культурные практики, сформировавшиеся в результате коммерциализации культурной сферы на примере города Волгограда. Отмечены их позитивные эффекты, дающие возможность более полно представить историю и культуру города. Особое внимание уделено опыту частных инициатив.
Comparing entanglement and identity effects in tunnelling
Creators: name: Sancho, Pedro
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The probability of simultaneous tunnelling of two particles is modified when the system is in a non-separable state, either entangled or symmetrised. We compare both effects in the rectangular potential barrier by evaluating the transmission rates in superposition states. For large momenta, their simultaneous presence greatly changes the form of the transmission rates. The joint effects are much larger than the superposition ones. Moreover, there are significant differences between bosons and fermions. We present an unified view of the combined effects as a quantum interference phenomenon. The analysis also illustrates a novel aspect of exclusion in entangled systems, the existence of superposition states one of whose terms is forbidden by Pauli's principle.
Defining Least Community as a Homogeneous Group in Complex Networks
Creators: name: Jiang, Bin
name: Ma, Ding
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Social and Information Networks (cs.SI)
subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: This paper introduces a new concept of least community that is as homogeneous as a random graph, and develops a new community detection algorithm from the perspective of homogeneity or heterogeneity. Based on this concept, we adopt head/tail breaks - a newly developed classification scheme for data with a heavy-tailed distribution - and rely on edge betweenness given its heavy-tailed distribution to iteratively partition a network into many heterogeneous and homogeneous communities. Surprisingly, the derived communities for any self-organized and/or self-evolved large networks demonstrate very striking power laws, implying that there are far more small communities than large ones. This notion of far more small things than large ones constitutes a new fundamental way of thinking for community detection. Keywords: head/tail breaks, ht-index, scaling, k-means, natural breaks, and classification
description: 9 pages, 3 figures, 3 tables; Physica A, 2015, xx(x), xx-xx
Method for estimating critical exponents in percolation processes with low sampling
Creators: name: Bastas, Nikolaos
name: Kosmidis, Kosmas
name: Giazitzidis, Paraskevas
name: Maragakis, Michael
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: In phase transition phenomena, the estimation of the critical point is crucial for the calculation of the various critical exponents and the determination of the universality class they belong to. However, this is not an easy task, since a huge amount of realizations is needed to eliminate the noise in the data. In this paper, we introduce a novel method for the simultaneous estimation of the critical point $p_c$ and the critical exponent $β/ν$, applied for the case of "explosive" bond percolation on $2D$ square lattices and ER networks. The results show that with only a few hundred of realizations, it is possible to acquire accurate values for these quantities. Guidelines are given at the end for the applicability of the method to other cases as well.
description: 6 pages, 5 figures
MMPI/MMPI-2 Changes in Long-Term Psychoanalytic Psychotherapy
Creators: name: Gordon, Robert
Publisher: name: figshare
Year: 2023
Subjects: Clinical psychology

description: The MMPI/MMPI-2, the most used and validated test of psychopathology, reacts poorly to "Empirically Supported Treatments", which are usually less than 20 sessions. The MMPI/MMPI-2 was tested with large dose therapy (long-term psychoanalytic psychotherapy) with 55 polysymptomatic outpatients. After M = 38.8 months (SD = 17.1) of treatment, scales F, Hs, D, Hy, Pd, Pt, Sc, Ma, and A, all significantly decreased to the normal range; most were p <.001. Scales K and Es which measure ego strength, increased significantly (both p<.001). A subsample of 18 patients with 3 testings, showed little change at M = 24.9 months (SD= 17). However, most of the scales changed significantly by M = 60.4 months (SD = 32; most p<.001). On the average, it took patients about 2 years to begin to make significant changes to their personalities, and they continued to improve for years. These results, using the MMPI/MMPI-2, support the validity of long-term psychotherapy.
Relating particle hygroscopicity and CCN activity to chemical composition during the HCCT-2010 field campaign
Creators: name: Wu, Z.J.
name: Poulain, L.
name: Henning, S.
name: Dieckmann, K.
name: Birmili, W.
name: Merkel, M.
name: Van Pinxteren, D.
name: Spindler, G.
name: Müller, K.
name: Stratmann, F.
name: Herrmann, H.
name: Wiedensohler, A.
Publisher: name: München : European Geopyhsical Union
Year: 2013
Subjects: subject: atmospheric chemistry
subject: chemical composition
subject: cloud condensation nucleus
subject: concentration (composition)
subject: evaporation
subject: hygroscopicity
subject: mountain region
subject: relative humidity
subject: 550

description: Particle hygroscopic growth at 90% RH (relative humidity), cloud condensation nuclei (CCN) activity, and size-resolved chemical composition were concurrently measured in the Thüringer Wald mid-level mountain range in central Germany in the fall of 2010. The median hygroscopicity parameter values, κ, of 50, 75, 100, 150, 200, and 250 nm particles derived from hygroscopicity measurements are respectively 0.14, 0.14, 0.17, 0.21, 0.24, and 0.28 during the sampling period. The closure between HTDMA (Hygroscopicity Tandem Differential Mobility Analyzers)-measured (κHTDMA) and chemical composition-derived (κchem) hygroscopicity parameters was performed based on the Zdanovskii–Stokes–Robinson (ZSR) mixing rule. Using size-averaged chemical composition, the κ values are substantially overpredicted (30 and 40% for 150 and 100 nm particles). Introducing size-resolved chemical composition substantially improved closure. We found that the evaporation of NH4NO3, which may happen in a HTDMA system, could lead to a discrepancy in predicted and measured particle hygroscopic growth. The hygroscopic parameter of the organic fraction, κorg, is positively correlated with the O : C ratio (κorg = 0.19 × (O : C) − 0.03). Such correlation is helpful to define the κorg value in the closure study. κ derived from CCN measurement was around 30% (varied with particle diameters) higher than that determined from particle hygroscopic growth measurements (here, hydrophilic mode is considered only). This difference might be explained by the surface tension effects, solution non-ideality, gas-particle partitioning of semivolatile compounds, and the partial solubility of constituents or non-dissolved particle matter. Therefore, extrapolating from HTDMA data to properties at the point of activation should be done with great care. Finally, closure study between CCNc (cloud condensation nucleus counter)-measured (κCCN) and chemical composition (κCCN, chem) was performed using CCNc-derived κ values for individual components. The results show that the κCCN can be well predicted using particle size-resolved chemical composition and the ZSR mixing rule.
What happy physicians have in common: A qualitative study of workplace perceptions of physicians with low burnout scores
Creators: name: Woodward, Rivers
name: Cheng, Tsaiwei
name: Latessa, Robyn
name: Galvin, Shelley L
name: Fromewick, Jill
Publisher: name: SAGE Publications Ltd
Year: 2022

description: Introduction: Burnout is a phenomenon in the medical field that adversely affects patient care, physician retention, and physician well-being. The preponderance of burnout research has primarily focused on exploring what parts of medical practice and individual characteristics contribute to burnout. Our research aims to add to the growing body of evidence exploring what physicians who love their work have in common. Methods: Physician participants in this qualitative study were recruited through their local medical society from those who indicated a willingness to share tips for joy in practice. Potential participants were then screened for low probability of burnout using a validated single-item burnout inventory. Nine primarily mid- to late-career physicians engaged in semi-structured interviews and thematic analysis was used to analyze data. Of the interviewed physicians, five were practicing in the primary care specialties of family or internal medicine and four in specialties outside of primary care. Results: Six major themes arose from the nine interviews and included variety in work, a sense of empowerment, connection with patients, visible impact of one?s work, feelings of community with coworkers and colleagues, and experiencing a sense of calling. Conclusion: While further research is needed to demonstrate the transferability of the themes from these interviews, an asset-rooted approach to physician wellness is a direction for research and intervention that deserves further attention. Focusing only on alleviating the factors that contribute to burnout is a worthy goal, but ignores the necessity of designing training systems and workplaces that are built to foster the elements of medicine that bring joy and fulfillment to practice.
Methane depletion in both polar regions of Uranus inferred from HST/STIS and Keck/NIRC2 observations
Creators: name: Sromovsky, Lawrence
name: Karkoschka, Erich
name: Fry, Patrick
name: Hammel, Heidi
name: de Pater, Imke
name: Rages, Kathy
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: From STIS observations of Uranus in 2012, we found that the methane volume mixing ratio declined from about 4% at low latitudes to about 2% at 60 deg N and beyond. This is similar to that found in the south polar regions in 2002, in spite of what appears to be strikingly different convective activity in the two regions. Keck and HST imaging observations close to equinox imply that the depletions were simultaneously present in 2007, suggesting they are persistent features. The depletions appear to be mainly restricted to the upper troposphere, with depth increasing poleward from about 30 deg N, reaching ~4 bars at 45 deg N and perhaps much deeper at 70 deg N. The latitudinal variations in degree and depth of the depletions are important constraints on models of meridional circulation. Our observations are qualitatively consistent with previously suggested circulation cells in which rising methane-rich gas at low latitudes is dried out by condensation and sedimentation of methane ice particles as the gas ascends to altitudes above the methane condensation level, then is transported to high latitudes, where it descends and brings down methane depleted gas. Since this cell would seem to inhibit formation of condensation clouds in regions where clouds are actually inferred from spectral modelling, it suggests that sparse localized convective events may be important in cloud formation. The small-scale latitudinal variations we found in the effective methane mixing ratio between 55 deg N and 82 deg N have significant inverse correlations with zonal mean latitudinal variations in cloud reflectivity in near-IR Keck images taken before and after the HST observations. If the CH4/H2 absorption ratio variations are interpreted as local variations in para fraction instead of methane mixing ratio, we find that downwelling correlates with reduced cloud reflectivity.
description: 20 pages, 19 figures, 4 tables, on-line supplemental material available