cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Molecular insights into psychedelic drug action
Creators: name: Roth B.L
name: Slocum S.T
name: DiBerto J.F
Publisher: name: John Wiley and Sons Inc
Year: 2022

description: A confluence of factors has renewed interest in the scientific understanding and translational potential of psychedelic drugs such as lysergic acid diethylamide (LSD), mescaline, and psilocybin: the desire for additional approaches to mental health care, incremental progress in basic and clinical research, and the reconsideration and relaxation of existing drug policies. With the United States Food and Drug Administration's designation of psilocybin as a “Breakthrough Therapy” for treatment-resistant depression, a new path has been forged for the conveyance of psychedelics to the clinic. Essential to the further development of such applications, however, is a clearer understanding of how these drugs exert their effects at the molecular level. Here we review the current knowledge regarding the molecular details of psychedelic drug actions and suggest that these discoveries can facilitate new insights into their hallucinogenic and therapeutic mechanisms.
sj-pdf-1-aor-10.1177_00034894211004368 – Supplemental material for Scholarly Research Productivity among Otolaryngology Residency Graduates and its Relationship to Future Academic Achievement
Creators: name: Johnson, Austin L.
name: Corcoran, Adam
name: Ferrell, Matthew
name: Johnson, Bradley S.
name: Mann, Scott E.
name: Villwock, Jennifer A.
name: Ferrell, Sydney
name: Vassar, Matt
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110315 Otorhinolaryngology
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-1-aor-10.1177_00034894211004368 for Scholarly Research Productivity among Otolaryngology Residency Graduates and its Relationship to Future Academic Achievement by Austin L. Johnson, Adam Corcoran, Matthew Ferrell, Bradley S. Johnson, Scott E. Mann, Jennifer A. Villwock, Sydney Ferrell and Matt Vassar in Annals of Otology, Rhinology & Laryngology
Molecular insights into the regulation of constitutive activity by RNA editing of 5HT2C serotonin receptors
Creators: name: Gumpper R.H
name: Roth B.L
name: Fay J.F
Publisher: name: Elsevier B.V.
Year: 2022

description: RNA editing is a process by which post-transcriptional changes of mRNA nucleotides alter protein function through modification of the amino acid content. The 5HT2C serotonin receptor, which undergoes 32 distinct RNA-editing events leading to 24 protein isoforms, is a notable example of this process. These 5HT2C isoforms display differences in constitutive activity, agonist/inverse agonist potencies, and efficacies. To elucidate the molecular mechanisms responsible for these effects of RNA editing, we present four active-state 5HT2C-transducer-coupled structures of three representative isoforms (INI, VGV, and VSV) with the selective drug lorcaserin (Belviq) and the classic psychedelic psilocin. We also provide a comprehensive analysis of agonist activation and constitutive activity across all 24 protein isoforms. Collectively, these findings reveal a unique hydrogen-bonding network located on intracellular loop 2 that is subject to RNA editing, which differentially affects GPCR constitutive and agonist signaling activities.
Effect of longitudinal proppant placement and engineering parameters on fracture conductivity
Creators: name: Lin, Zhi
name: Liu, Yuxuan
name: Song, Guojie
name: Chen, Yali
name: Chen, Puchun
name: Guo, Jianchun
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Biophysics
Space Science
Medicine
Neuroscience
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Plasma Physics
Mental Health

description: Uncertainty regarding the factors affecting fracture conductivity is a core issue in hydraulic fracturing, and previous conductivity studies have not considered the effects of longitudinal proppant placement and engineering parameters on conductivity. In this study, a proppant transport model for engineering-scale fractures was developed using the Eulerian–Eulerian method. The conductivity model distinguishes between propped and unpropped regions in the longitudinal direction of the proppant. Proppant embedding and deformation in the propped region are calculated based on Hertz’s elastic contact theory, whereas the permeability is estimated using the Kozeny–Carman formula. The unpropped region defines the degree of residual tensile opening, and the permeability is calculated using the cubic law. The results indicate an optimal ratio of proppant bed height to fracture height of ∼13/40, which maximizes the conductivity. This study provides critical insights for optimizing fracture conductivity and provides a workflow that integrates proppant placement and conductivity. The influence of engineering parameters on the morphology and conductivity of sand packs was also investigated. A proppant placement model is established.According to the proppant placement form, the prediction model of flow conductivity is established.The influence of dome coefficient and closing pressure on diversion capacity is analyzed.Based on the engineering parameters, the variation law of diversion capacity is studied. A proppant placement model is established. According to the proppant placement form, the prediction model of flow conductivity is established. The influence of dome coefficient and closing pressure on diversion capacity is analyzed. Based on the engineering parameters, the variation law of diversion capacity is studied.
Simulation study of gas hydrate production using various thermal stimulation methods in the Ulleung Basin of the Korean East Sea
Creators: name: Lee, Taehun
name: Ahn, Taewoong
name: Park, Sunyoung
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Generally, depressurization method is utilized for gas hydrate production because of its simplicity and low cost. However, this method can cause severe subsidence problems in unconsolidated gas hydrate zones. Accordingly, the development of production method with high productivity and geomechanical stability is required in order to sustainable gas hydrate production. This can be achieved through the combination of various production methods. In this study, we conducted simulation studies using thermal stimulation methods combined with depressurization method and cyclic depressurization method using STARS of CMG. A 3D reservoir model was constructed with the field scale using geological and experimental data from the Ulleung Basin of the Korean East Sea. In most cases, the cumulative gas production was significantly increased using thermal stimulation methods. In particular, wellbore heating stimulation showed good production results compared to other thermal stimulation cases. In addition, the results of applying the cyclic depressurization method showed a significant increase in geomechanical stability. Therefore, the wellbore heating method with cyclic depressurization was found to be the optimal development strategy in terms of productivity and stability. This study is believed to contribute to commercial gas hydrate production using combined production methods study.
A Datagram Api For Evolving Networks Beyond 5G
Creators: name: Jones, Tom
name: Gorry Fairhurst
name: Vyncke, Eric
Publisher: name: Zenodo
Year: 2017
Subjects: transport evolution
provisioning domains
pvd
ietf
neat

description: Abstract:

The UDP Socket API has matured to support a wide range of uses, while only offering minimal services to applications. This poster describes the high-level Datagram API offered by the NEAT System and how this enables applications to take advantage of information about the available network services, to effectively use next generation networks.
Additional file 1 of Examining the referral of patients with elevated blood pressure to health resources in an under-resourced community in South Africa
Creators: name: McNulty, Lia K.
name: Stoutenberg, Mark
name: Kolkenbeck-Ruh, Andrea
name: Harrison, Amy
name: Mmoledi, Thabiso
name: Katiyo, Daniel
name: Mhlaba, Mimi
name: Kubheka, Delisile
name: Ware, Lisa J.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional File 1: Semi-structured interview guides mapped onto Andersen’s Expanded Behavioral Model
Le Codepoint: Preliminary Results And Ongoing Work In The Ietf: Internet Reserach Task Force (Map-Rg) Meeting Presentation
Creators: name: Gorry Fairhurst
name: Custura, Ana
name: Venne, Andre
name: Jones, Tom
Publisher: name: Zenodo
Year: 2018
Subjects: ietf
dscp
transport evolution

description: University of Aberdeen
Fish symbol and maritime motifs on late antique lamps from Central Balkans
Creators: name: Tešić Radovanović, Danijela
Publisher: name: Humanities Commons
Year: 2022
Subjects: subject: Art
subject: Idols and images
subject: Lamps

description: Elements of Christian visual culture appeared in various media in monumental and applied art during the late antique period, from painted decoration in the catacombs, through funerary monuments, to utilitarian objects such as jewellery and lamps. The paper analyses the symbolic meaning of fish and maritime motifs in the context of the late antique visual culture of the Mediterranean and their meaning within the Interpretatio Christiana, as well as the appearance of these motifs on late antique lamps. Ten lamps with maritime motifs or in the form of fish or dolphins are known from the territory of the Central Balkans. Elements of decoration are considered in relation to analogies, textual references, and the context of the finds.
Additional file 1 of Influence of scat ageing on the gut microbiome: how old is too old?
Creators: name: Oliveros, Alejandro
name: Terraube, Julien
name: Levengood, Alexis L.
name: Powell, Daniel
name: Frère, Céline H.
Publisher: name: figshare
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional file 1: Contains the following supplementary results, figures, and tables: Supplementary Results: Detailed discussion and analysis of the Jaccard dissimilarity (PCoA) results. The discussion focuses on the presence/absence of ASVs in bacteria and fungi over time and how these affect the gut microbiome. Figure S1: Picture of Scat aging setup. Figure S2: Phylogenetic beta diversity plots for bacteria. Figure S3: Effect of time after 72 hrs of scat aging in fungi. Figure S4: Comparison of beta diversity between koalas. Figure S5: The effect of scat aging on bacterial beta diversity metrics. Table S1: Bacteria Quality control metrics. Table S2: Fungi Quality control metrics. Table S3: Respiration profile of 27 most abundant taxonomic families for bacteria.
La mecanización agrícola: campo de acción de la ingeniería agronómica
Creators: name: fernando fercho1234, Muñoz
Publisher: name: unknown
Year: 2023

description: La mecanización agrícola ha sido un tema fundamental en el campo de la ingeniería agronómica. Este artículo tiene como objetivo presentar un resumen del campo de acción de la ingeniería agronómica en relación con la mecanización agrícola.

La mecanización agrícola se refiere al uso de maquinaria y tecnología en las actividades agrícolas para aumentar la eficiencia, la productividad y la rentabilidad. La ingeniería agronómica desempeña un papel crucial en este campo, ya que se encarga de diseñar, desarrollar y optimizar equipos y sistemas para su implementación en la agricultura.

Uno de los aspectos clave de la mecanización agrícola es la maquinaria agrícola. Los ingenieros agrónomos trabajan en el diseño y la mejora de tractores, cosechadoras, sembradoras, pulverizadoras y otros equipos utilizados en el campo. Estos equipos deben ser eficientes, duraderos y resistentes a las condiciones adversas del entorno agrícola.

Además del diseño de maquinaria, la ingeniería agronómica se ocupa de la gestión y optimización de sistemas agrícolas mecanizados. Esto implica el análisis de las necesidades y los requisitos de los agricultores, la planificación de la maquinaria necesaria, la capacitación de los operadores y la implementación de prácticas de mantenimiento adecuadas.
Molecular signatures of in situ to invasive progression for basal-like breast cancers: An integrated mouse model and human DCIS study
Creators: name: Thennavan, A
name: Garcia-Recio, S
name: Perou, C.M
name: He, X
name: Liu, S
Publisher: name: Nature Research
Year: 2022

description: Ductal carcinoma in situ (DCIS) of the breast is a non-obligate precursor of Invasive Ductal Carcinoma (IDC) and thus the identification of features that may predict DCIS progression would be of potential clinical value. Experimental mouse models can be used to address this challenge by studying DCIS-to-IDC biology. Here we utilize single cell RNA sequencing (scRNAseq) on the C3Tag genetically engineered mouse model that forms DCIS-like precursor lesions and for which many lesions progress into end-stage basal-like molecular subtype IDC. We also perform bulk RNAseq analysis on 10 human synchronous DCIS-IDC pairs comprised of estrogen receptor (ER) positive and ER-negative subsets and utilize 2 additional public human DCIS data sets for comparison to our mouse model. By identifying malignant cells using inferred DNA copy number changes from the murine C3Tag scRNAseq data, we show the existence of cancer cells within the C3Tag pre-DCIS, DCIS, and IDC-like tumor specimens. These cancer cells were further classified into proliferative, hypoxic, and inflammatory subpopulations, which change in frequency in DCIS versus IDC. The C3Tag tumor progression model was also associated with increase in Cancer-Associated Fibroblasts and decrease in activated T cells in IDC. Importantly, we translate the C3Tag murine genomic findings into human DCIS where we find common features only with human basal-like DCIS, suggesting there are intrinsic subtype unique DCIS features. This study identifies several tumor and microenvironmental features associated with DCIS progression and may also provide genomic signatures that can identify progression-prone DCIS within the context of human basal-like breast cancers.
sj-pdf-1-jrs-10.1177_01410768211001583 - Supplemental material for Environmental impact of personal protective equipment distributed for use by health and social care services in England in the first six months of the COVID-19 pandemic
Creators: name: Rizan, Chantelle
name: Reed, Malcolm
name: Bhutta, Mahmood F
Publisher: name: SAGE Journals
Year: 2021
Subjects: Medicine

description: Supplemental material, sj-pdf-1-jrs-10.1177_01410768211001583 for Environmental impact of personal protective equipment distributed for use by health and social care services in England in the first six months of the COVID-19 pandemic by Chantelle Rizan, Malcolm Reed and Mahmood F Bhutta in Journal of the Royal Society of Medicine
Qos Challenges For Real Time Traffic: Deployable Qos Using The Neat System
Creators: name: Jones, Tom
Publisher: name: Zenodo
Year: 2017

description: Quality of Service markings can benefit real time traffic. A survey we conducted on a mobile cellular testbed (Monroe) has revealed how differentiated services traffic is treated in practical networks, and shows many networks do not respect diffserv markings resulting unpredictable real-time performance.

This motivates a change to the network programming API for real-time traffic to provide dynamic transport selection and fallback, enabling successful use of network QoS. The API is presented in the context of the NEAT1 open source project.
Mortality differences among patients with in-hospital ST-elevation myocardial infarction
Creators: name: Jacobs, A
name: Shahandeh, N
name: Press, M.C
name: Jaski, B
name: Smith, Jr., S.C
name: Dave, R
name: Denktas, A
name: Markovic, D
name: Levine, G
name: Dai, X
Publisher: name: John Wiley and Sons Inc
Year: 2020

description: Background: In-hospital ST-elevation myocardial infarction (STEMI) is associated with a higher mortality rate than out-of-hospital STEMI. Quality measures and universal protocols for treatment of in-hospital STEMI do not exist, likely contributing to delays in recognition and treatment. Hypothesis: To analyze differences in mortality among three subsets of patients who develop in-hospital STEMI. Methods: This was a multicenter, retrospective observational study of patients who developed in-hospital STEMI at six United States medical centers between 2008 and 2017. Patients were stratified into three groups: (1) cardiac, (2) periprocedure, or (3) noncardiac/nonpostprocedure. Outcomes examined include time from electrocardiogram (ECG) acquisition to cardiac catheterization lab arrival (ECG-to-CCL) and survival to discharge. Results: We identified 184 patients with in-hospital STEMI (mean age 68.7 years, 58.7% male). Group 1 (cardiac) patients had a shorter average ECG-to-CCL time (69 minutes) than group 2 (periprocedure, 215 minutes) and group 3 (noncardiac/nonpostprocedure, 199 minutes). Compared to group 1, survival to discharge was lower for group 2 (OR 0.33, P =.102) and group 3 (OR 0.20, P =.016). After adjusting for prespecified covariates, the relationship between group and survival showed a similar trend but did not reach statistical significance. Conclusions: Patients who develop in-hospital STEMI in the context of a preceding procedure or noncardiac illness appear to have longer reperfusion times and higher in-hospital mortality than patients admitted with cardiac diagnoses. Larger studies are warranted to further investigate these observations. Health systems should place an increased emphasis on developing quality metrics and implementing quality improvement initiatives to improve outcomes for in-hospital STEMI.
Credit VaR Model
Creators: name: Lee, David
Publisher: name: Humanities Commons
Year: 2023
Subjects: subject: Credit ratings
subject: Risk management

description: Credit value at risk (VaR) is used for measuring and analyzing credit risk of a portfolio. The basic methodology of the Credit VaR employs the credit migration approach spearheaded by RiskMetrics. It assumes that obligor’s credit quality is determined by the obligor’s asset value, which in turn is approximated by its standardized equity return.
sj-docx-1-psp-10.1177_0146167221992213 – Supplemental material for Equal Performance, Different Grade: Women’s Performance in Discussion Perceived Worse Than Men’s
Creators: name: Dorrough, Angela R.
name: Leszczyńska, Monika
name: Werner, Sandra
name: Schaeffer, Lovis
name: Anna-Sophie Galley
name: Akin, Enis
name: Bachmann, Jacqueline
name: Bruske, Marius
name: Burghardt, Ulla
name: Simandi, Franziska
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, sj-docx-1-psp-10.1177_0146167221992213 for Equal Performance, Different Grade: Women’s Performance in Discussion Perceived Worse Than Men’s by Angela R. Dorrough, Monika Leszczyńska, Sandra Werner, Lovis Schaeffer, Anna-Sophie Galley, Enis Akin, Jacqueline Bachmann, Marius Bruske, Ulla Burghardt and Franziska Simandi in Personality and Social Psychology Bulletin
sj-pdf-1-eex-10.1177_2515127420931753 - Supplemental material for University Startup Accelerators: Startup Launchpads or Vehicles for Entrepreneurial Learning?
Creators: name: Metcalf, Lynn E.
name: Katona, Thomas M.
name: York, Jonathan L.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business

description: Supplemental material, sj-pdf-1-eex-10.1177_2515127420931753 for University Startup Accelerators: Startup Launchpads or Vehicles for Entrepreneurial Learning? by Lynn E. Metcalf, Thomas M. Katona and Jonathan L. York in Entrepreneurship Education and Pedagogy
Credit VaR Model
Creators: name: Lee, David
Publisher: name: unknown
Year: 2023
Subjects: subject: Risk management
subject: Credit ratings

description: Credit value at risk (VaR) is used for measuring and analyzing credit risk of a portfolio. The basic methodology of the Credit VaR employs the credit migration approach spearheaded by RiskMetrics. It assumes that obligor's credit quality is determined by the obligor's asset value, which in turn is approximated by its standardized equity return.
sj-pdf-4-tar-10.1177_1753466621992735 – Supplemental material for Percutaneous endoscopic gastrostomy feeding effects in patients with neurogenic dysphagia and recurrent pneumonia
Creators: name: Lee, Jung Hwan
name: Kwon, Hea Yoon
name: Kwon, Kye Sook
name: Park, Soo-Hyun
name: Suh, Young Ju
name: Kim, Jung-Soo
name: Hyungkil Kim
name: Shin, Yong Woon
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine
subject: 110203 Respiratory Diseases

description: Supplemental material, sj-pdf-4-tar-10.1177_1753466621992735 for Percutaneous endoscopic gastrostomy feeding effects in patients with neurogenic dysphagia and recurrent pneumonia by Jung Hwan Lee, Hea Yoon Kwon, Kye Sook Kwon, Soo-Hyun Park, Young Ju Suh, Jung-Soo Kim, Hyungkil Kim and Yong Woon Shin in Therapeutic Advances in Respiratory Disease
Mortality in Patients Hospitalized With Acute Myocardial Infarction Without Standard Modifiable Risk Factors: The ARIC Study Community Surveillance
Creators: name: Hendrickson, M
name: Levisay, J.P
name: Bangalore, S
name: Smith, S
name: Blankstein, R
name: Ricciardi, M.J
name: Chunawala, Z.S
name: Bhatt, D.L
name: Erwin, J.P
name: Arora, S
name: Rosenberg, J.R
name: Caughey, M.C
name: Matsushita, K
name: Qamar, A
Publisher: name: American Heart Association Inc.
Year: 2023

description: BACKGROUND: Prevention strategies targeting standard modifiable cardiovascular risk factors (SMuRFs; diabetes, hyperten-sion, smoking, hypercholesterolemia) are critical to improving cardiovascular disease outcomes. However, acute myocardial infarction (AMI) among individuals who lack 1 or more SMuRFs is not uncommon. Moreover, the clinical characteristics and prognosis of SMuRFless individuals are not well characterized. METHODS AND RESULTS: We analyzed AMI hospitalizations from 2000 to 2014 captured by the ARIC (Atherosclerosis Risk in Community) study community surveillance. AMI was classified by physician review using a validated algorithm. Clinical data, medications, and procedures were abstracted from the medical record. Main study outcomes included short-and long-term mortality within 28 days and 1 year of AMI hospitalization. Between 2000 and 2014, a total of 742 (3.6%) of 20 569 patients with AMI were identified with no documented SMuRFs. Patients without SMuRFs were less likely to receive aspirin, nonaspirin antiplatelet therapy, or beta blockers and less often underwent angiography and revascularization. Compared with those with one or more SMuRFs, patients without SMuRFs had significantly higher 28-day (odds ratio, 3.23 [95% CI, 1.78–5.88]) and 1-year (hazard ratio, 2.09 [95% CI, 1.29–3.37]) adjusted mortality. When examined across 5-year intervals from 2000 to 2014, the incidence of 28-day mortality significantly increased for patients without SMuRFs (7% to 15% to 27%), whereas it declined for those with 1 or more SMuRFs (7% to 5% to 5%). CONCLUSIONS: Individuals without SMuRFs presenting with AMI have an increased risk of all-cause mortality with an overall lower prescription rate for guideline-directed medical therapy. These findings highlight the need for evidence-based pharma-cotherapy during hospitalization and the need to discover new markers and mechanisms for early risk identification in this population.
A New, Evolutive Api And Transport-Layer Architecture For The Internet
Creators: name: Jones, Tom
Publisher: name: Zenodo
Year: 2017
Subjects: transport evolution
dscp
real time traffic
rtp

description: Internet Transport is changing, some changes have been incremental updates to mechanisms (e.g., RACK, BBR), others demand new protocol options (e.g., MPTCP) or entirely new protocols (e.g., QUIC, SCTP). However significant changes are still difficult to deploy - requiring modifications to application code and support by the stack. Even when updates happen, the network needs to support the new method to allow applications to use it. Long deployment times have motivated the need to change how protocols are handled in the stack. We review the state of the art in Internet Transport, and the status of deployment in th BSD's and then propose a new direction for the transport interface, developed in the EU NEAT Project, that can ease deployment of new transports across all platforms. We conclude by showing the advantages and its prospects for standards adoption.
Copper-alloy coin weight? (unnumbered)
Creators: name: Hamerow, Helena
Publisher: name: University of Oxford
Year: 2021
Subjects: Archaeology

description: Gatty Slip: Roman very thin brass weight, found at Gilton in Kent. Formerly in the Faussett Coll., vide Inven. Sep. pp. 22, 23 (Grave 66) pl. 17 (without number in right hand corner)Mayer card: Bronze weight 5/8 inch diameter.Not mentioned in Table 3 in Scull 1990. – B.B.
Additional file 1 of The impact of COVID-19 on the changes in health behaviours among Black, Asian and Minority Ethnic (BAME) communities in the United Kingdom (UK): a scoping review
Creators: name: Nduka, Ifunanya
name: Kabasinguzi, Isabella
name: Ali, Nasreen
name: Ochepo, Peter
name: Abdy, David
name: Cook, Erica Jane
name: Egbutah, Chimeme
name: Cartwright, Sally
name: Randhawa, Gurch
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Additional file 1.
Copper-alloy coin weight (No. 19)
Creators: name: Hamerow, Helena
Publisher: name: University of Oxford
Year: 2021
Subjects: Archaeology

description: Mayer card: Coin of Flavius Julius Constantius.Faussett did not consider this a coin weight, but describes it separately as an individual coin. The gatty slip for M 6049 simply indicates that it is a coin, not a weight. – B.B. & D.H.
mRNA vaccine for cancer immunotherapy
Creators: name: Huang, L
name: Miao, L
name: Zhang, Y
Publisher: name: BioMed Central Ltd
Year: 2021

description: mRNA vaccines have become a promising platform for cancer immunotherapy. During vaccination, naked or vehicle loaded mRNA vaccines efficiently express tumor antigens in antigen-presenting cells (APCs), facilitate APC activation and innate/adaptive immune stimulation. mRNA cancer vaccine precedes other conventional vaccine platforms due to high potency, safe administration, rapid development potentials, and cost-effective manufacturing. However, mRNA vaccine applications have been limited by instability, innate immunogenicity, and inefficient in vivo delivery. Appropriate mRNA structure modifications (i.e., codon optimizations, nucleotide modifications, self-amplifying mRNAs, etc.) and formulation methods (i.e., lipid nanoparticles (LNPs), polymers, peptides, etc.) have been investigated to overcome these issues. Tuning the administration routes and co-delivery of multiple mRNA vaccines with other immunotherapeutic agents (e.g., checkpoint inhibitors) have further boosted the host anti-tumor immunity and increased the likelihood of tumor cell eradication. With the recent U.S. Food and Drug Administration (FDA) approvals of LNP-loaded mRNA vaccines for the prevention of COVID-19 and the promising therapeutic outcomes of mRNA cancer vaccines achieved in several clinical trials against multiple aggressive solid tumors, we envision the rapid advancing of mRNA vaccines for cancer immunotherapy in the near future. This review provides a detailed overview of the recent progress and existing challenges of mRNA cancer vaccines and future considerations of applying mRNA vaccine for cancer immunotherapies.
Valuation of Shrinking Basket Option Based on the Worst Return.
Creators: name: Lee, David
Publisher: name: Humanities Commons
Year: 2023
Subjects: subject: Derivative securities
subject: Stock exchanges
subject: Options (Finance)

description: A model is used to price a derivative whose payoff depends on returns over N periods on a shrinking basket of originally N assets. Each period, the worst return is added to the cumulative sum after being capped and floored, and the corresponding asset removed from the basket (hence a shrinking basket). The cap and floor rates are given for each period and the total cumulative sum is also constrained by a global cap and floor. The payment thus represents a path dependent option.
Supporting information for Dual LC column characterization for mass spectrometry-based small molecule profiling of human plasma and serum
Creators: name: Tkalec, Žiga
name: Koudelka, Štěpán
name: Klánová, Jana
name: Price, Elliott J.
Publisher: name: Zenodo
Year: 2024
Subjects: subject: Mass spectrometry
subject: Analytical chemistry

description: Here we present details on column characterization study using 602 chemical standards analysed via a dual column system using Cogent Diamond Hydride 2.o, 2.2 µm, 2.1 × 100 mm column in aqueous normal phase (ANP) mode and Cosmosil PBr, 2.6 µm, 2.1 × 150 mm in reversed-phase (RP) mode. Repeatability and reproducibility of retention time, peak length, peak area and peak height were analysed. Based on retention times of standards, separation mechanism was estimated and predicted retention time models based on quantitative structure retention relationship (QSRR) constructed for both columns. Curated and substructure assigned MS2 libraries of standards retained or detected on the columns were constructed.
description: Work was funded by the European Union’s Horizon Europe programme under the grant agreement 101130769 (FRANKIE) and was supported from the European Union’s Horizon 2020 research and innovation programme under grant agreement 857560 (CETOCOEN Excellence). Support from National Institute for Neurological Research (Programme EXCELES, ID Project No. LX22NPO5107) - Funded by the European Union – Next Generation EU is acknowledged and the RECETOX Research Infrastructure (No LM2023069) financed by the MEYS thanked for supportive background.
Transport Features Of The User Datagram Protocol (Udp) And Lightweight Udp (Udp-Lite) (Rfc8304)
Creators: name: Godred Fairhurst
name: Jones, Tom
Publisher: name: Zenodo
Year: 2018
Subjects: ietf
udp
transport evolution

description:  This is an informational document that describes the transport
   protocol interface primitives provided by the User Datagram Protocol
   (UDP) and the Lightweight User Datagram Protocol (UDP-Lite) transport
   protocols.  It identifies the datagram services exposed to
   applications and how an application can configure and use the
   features offered by the Internet datagram transport service.  RFC
   8303 documents the usage of transport features provided by IETF
   transport protocols, describing the way UDP, UDP-Lite, and other
   transport protocols expose their services to applications and how an
   application can configure and use the features that make up these
   services.  This document provides input to and context for that
   document, as well as offers a road map to documentation that may help
   users of the UDP and UDP-Lite protocols.
Additional file 1 of Association between atherogenic index of plasma control level and incident cardiovascular disease in middle-aged and elderly Chinese individuals with abnormal glucose metabolism
Creators: name: Min, Qianqian
name: Wu, Zhigang
name: Yao, Jiangnan
name: Wang, Siyi
name: Duan, Lanzhi
name: Liu, Sijia
name: Zhang, Mei
name: Luo, Yanhong
name: Ye, Dongmei
name: Huang, Yuxu
name: Chen, Lan
name: Xu, Ke
name: Zhou, Jianghua
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Mental Health

description: Supplementary Material 1
mTADA is a framework for identifying risk genes from de novo mutations in multiple traits
Creators: name: Buxbaum J.D
name: Stahl E.A
name: Purcell S.M
name: Riley B.P
name: Brown R.C
name: Pinto D
name: He X
name: Dobbyn A
name: Sullivan P.F
name: Nguyen T.-H
Publisher: name: Nature Research
Year: 2020

description: Joint analysis of multiple traits can result in the identification of associations not found through the analysis of each trait in isolation. Studies of neuropsychiatric disorders and congenital heart disease (CHD) which use de novo mutations (DNMs) from parent-offspring trios have reported multiple putatively causal genes. However, a joint analysis method designed to integrate DNMs from multiple studies has yet to be implemented. We here introduce multiple-trait TADA (mTADA) which jointly analyzes two traits using DNMs from non-overlapping family samples. We first demonstrate that mTADA is able to leverage genetic overlaps to increase the statistical power of risk-gene identification. We then apply mTADA to large datasets of >13,000 trios for five neuropsychiatric disorders and CHD. We report additional risk genes for schizophrenia, epileptic encephalopathies and CHD. We outline some shared and specific biological information of intellectual disability and CHD by conducting systems biology analyses of genes prioritized by mTADA.
Valuation of Shrinking Basket Option Based on the Worst Return.
Creators: name: Lee, David
Publisher: name: unknown
Year: 2023
Subjects: subject: Stock exchanges
subject: Derivative securities
subject: Options (Finance)

description: A model is used to price a derivative whose payoff depends on returns over N periods on a shrinking basket of originally N assets. Each period, the worst return is added to the cumulative sum after being capped and floored, and the corresponding asset removed from the basket (hence a shrinking basket). The cap and floor rates are given for each period and the total cumulative sum is also constrained by a global cap and floor. The payment thus represents a path dependent option.
Der Fotoeffekt
Creators: name: Schröer, Harald
Publisher: name: Zenodo
Year: 2015
Subjects: relativistic,foto,effect,frequency,kinetic energy,electron

description: Mit Hilfe der kinetischen Energie wird die Grenzfrequenz bzw. die Auslösearbeit beim Fotoeffekt bestimmt, dazu gehört auch eine relativistische Betrachtung.
description: German
Mucus concentration–dependent biophysical abnormalities unify submucosal gland and superficial airway dysfunction in cystic fibrosis
Creators: name: Hill, D.B
name: Burns, K.A
name: Ballard, S.T
name: Boucher, R.C
name: Gilmore, R.C
name: Markovetz, M.R
name: Brennan, T.A
name: Randell, S.H
name: Button, B
name: Stoychev, G.V
name: Neal, W.K.O
name: Porterfield, M
name: Papanikolas, M.J
name: Ehre, C
name: Forsberg, L.J
name: Barbosa Cardenas, S.M
name: Thacker, H
name: Kato, T
name: Aoki, K
name: Goodell, H.P
name: Freeman, R
name: Radicioni, G
name: Tiemeyer, M
name: Morrison, C.B
name: Rubinstein, M
name: Nagase, T
name: Kesimer, M
name: Loznev, H.T
name: Okuda, K
name: White, K.K
Publisher: name: American Association for the Advancement of Science
Year: 2022

description: Cystic fibrosis (CF) is characterized by abnormal transepithelial ion transport. However, a description of CF lung disease pathophysiology unifying superficial epithelial and submucosal gland (SMG) dysfunctions has remained elusive. We hypothesized that biophysical abnormalities associated with CF mucus hyperconcentration provide a unifying mechanism. Studies of the anion secretion–inhibited pig airway model of CF revealed elevated SMG mucus concentrations, osmotic pressures, and SMG mucus accumulation. Human airway studies revealed hyperconcentrated CF SMG mucus with raised osmotic pressures and cohesive forces predicted to limit SMG mucus secretion/release. Using proline-rich protein 4 (PRR4) as a biomarker of SMG secretion, CF sputum proteomics analyses revealed markedly lower PRR4 levels compared to healthy and bronchiectasis controls, consistent with a failure of CF SMGs to secrete mucus onto airway surfaces. Raised mucus osmotic/cohesive forces, reflecting mucus hyperconcentration, provide a unifying mechanism that describes disease-initiating mucus accumulation on airway surfaces and in SMGs of the CF lung.
Additional file 1 of Rayleigh step-selection functions and connections to continuous-time mechanistic movement models
Creators: name: Eisaguirre, Joseph M.
name: Williams, Perry J.
name: Hooten, Mevin B.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified

description: Additional file 1. Supplementary figure.
A Generative Praxis Curation, Creation, and Black Counterpublics
Creators: name: C. Chambliss, Julian
name: French, Scot
Publisher: name: Humanities Commons
Year: 2022
Subjects: subject: Public history
subject: History

description: Since 2016, the academic narrative emerging from the Zora Neale Hurston Festival of the Arts and Humanities in Eatonville, Florida, has increasingly relied on a public scholarship model to bridge the gap between institutional practice and community knowledge. Inspired by Zora Neale Hurston’s legacy as an interdisciplinary scholar, these activities have turned toward generative digital practices to document, share, and preserve the scholarly and community knowledge associated with this event. This change reflects Edward L. Ayers’s call for a more robust and inclusively engaged scholarship that speaks to the need to identify the deeply rooted cultural questions traditional narratives all too easily overlook. By allying with the Association to Preserve the Eatonville Community, Inc. (PEC), we leverage digital humanities practices to better understand the experiences of heritage communities. In this way, we see our work as building on Kim Gallon’s call for a digital humanities that seeks to apprehend the constructed nature of race and the impact of racism on society.1 Our praxis has evolved into a three-pronged strategy of public scholarship, digital pedagogy, and open educational resource curation designed to engage the public and shape scholarly narratives in new ways. The project spotlights a commitment to combine and amplify pedagogy and digital methodologies in order to create unique and sustainable archival materials for future research.
Additional file 1 of Evaluating completion rates of COVID-19 contact tracing surveys in New York City
Creators: name: He, Kaiyu
name: Foerster, Steffen
name: Vora, Neil M.
name: Blaney, Kathleen
name: Keeley, Chris
name: Hendricks, Lisa
name: Varma, Jay K.
name: Long, Theodore
name: Shaman, Jeffrey
name: Pei, Sen
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1.
Supplemental material for this article available online.
Creators: name: Hong, Jun Sung
name: Espelage, Dorothy L.
name: Ostrov, Jamie M.
name: Greco, Ana M.
name: Gómez, Eva Pérez
name: Pereda, Noemí
name: Guilera, Georgina
name: González, Iriana Santos
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law

description: Supplemental Material for Why Do School Staff Sometimes Fail to Report Potential Victimization Cases? A Mixed-methods Study by Ana M. Greco, Eva Pérez Gómez, Noemí Pereda, Georgina Guilera and Iriana Santos González, in Journal of Interpersonal Violence
Multi-omics of NET formation and correlations with CNDP1, PSPB, and L-cystine levels in severe and mild COVID-19 infections
Creators: name: Gritsenko M.A
name: Tsutsumi T
name: Paurus V.L
name: Uwamino Y
name: Bramer L.M
name: Ishida K
name: Tateno H
name: Baba R
name: Ishii M
name: Sims A.C
name: Waters K.M
name: Nakachi I
name: Nakamura M
name: Suzuki S
name: Gerbasi V.R
name: Stratton K.G
name: Yotsuyanagi H
name: Koga M
name: Nakayasu E.S
name: Schepmoes A.A
name: Iwatsuki-Horimoto K
name: Attah I.K
name: Mitamura K
name: Letizia A.G
name: Kato H
name: Akasaka O
name: Hontz R.D
name: Metz T.O
name: Nakajima H
name: Nicora C.D
name: Kim Y.-M
name: Corson K
name: Eisfeld A.J
name: Kawaoka Y
Publisher: name: Elsevier Ltd
Year: 2023

description: The detailed mechanisms of COVID-19 infection pathology remain poorly understood. To improve our understanding of SARS-CoV-2 pathology, we performed a multi-omics and correlative analysis of an immunologically naïve SARS-CoV-2 clinical cohort from blood plasma of uninfected controls, mild, and severe infections. Consistent with previous observations, severe patient populations showed an elevation of pulmonary surfactant levels. Intriguingly, mild patients showed a statistically significant elevation in the carnosine dipeptidase modifying enzyme (CNDP1). Mild and severe patient populations showed a strong elevation in the metabolite L-cystine (oxidized form of the amino acid cysteine) and enzymes with roles in glutathione metabolism. Neutrophil extracellular traps (NETs) were observed in both mild and severe populations, and NET formation was higher in severe vs. mild samples. Our correlative analysis suggests a potential protective role for CNDP1 in suppressing PSPB release from the pulmonary space whereas NET formation correlates with increased PSPB levels and disease severity. In our discussion we put forward a possible model where NET formation drives pulmonary occlusions and CNDP1 promotes antioxidation, pleiotropic immune responses, and vasodilation by accelerating histamine synthesis.
Term of Structure of Implied Volatility Model
Creators: name: Lee, David
Publisher: name: Humanities Commons
Year: 2023
Subjects: subject: Risk management
subject: Options (Finance)
subject: Derivative securities

description: Equity value at risk (VaR) model requires implied volatilities with respect to various indices and maturities, which range from three months to five years. A model is presented for generating a term-structure of implied equity index volatilities for use in calculating VaR.
Term of Structure of Implied Volatility Model
Creators: name: Lee, David
Publisher: name: unknown
Year: 2023
Subjects: subject: Risk management
subject: Derivative securities
subject: Options (Finance)

description: Equity value at risk (VaR) model requires implied volatilities with respect to various indices and maturities, which range from three months to five years. A model is presented for generating a term-structure of implied equity index volatilities for use in calculating VaR.
Théorie du chaos - Théorie de la synchronicité ; Le nombre 42 et le sens de la vie + Viktor Frankl & Dr. Wong & Conscience collective auto-organisée - Synchronicité.- Fandom, C Cusack & C Hall - Symbolisme spirituel inconscient+ Spiritual Prism Paradigm
Creators: name: Peck Jr, Charles
Publisher: name: Humanities Commons
Year: 2008
Subjects: subject: Chaotic behavior in systems
subject: Jungian psychology
subject: Coincidence
subject: Paranormal fiction
subject: French literature
subject: Philosophy, French
subject: Painting, French
subject: Guénon, René
subject: Precognition

description: La théorie du chaos n'est pas aussi complexe qu'on le prétend souvent Comme l'observe Robert Juliano, le principe sous-jacent est que "dans le caractère aléatoire apparent des systèmes complexes chaotiques, il existe des modèles sous-jacents, des interconnexions, des boucles de rétroaction constantes, la répétition, l'auto-similarité , fractales et auto-organisation.   "Le chaos a été formellement défini par la Royal Society (1986) comme "un comportement stochastique dans un système déterministe" et est donc un système qui, bien qu'affichant un comportement apparemment aléatoire, a un modèle et une légalité sous-jacents !" Comme l'a expliqué Robert Juliano, un expert qui a une "formation en science de la complexité" et qui a "travaillé avec des systèmes dynamiques auto-organisés", "la théorie du chaos est une approche multidisciplinaire de la dynamique des systèmes déterministes, [et] ce qui émerge de eux. La définition du « chaos » par la théorie du chaos est mathématiquement orientée, n'est pas considérée comme universelle et est aussi précise que restrictive. »  Nancy Furlotti, dans son article, Tracing a Red Thread: Synchronicity and Jung's Red Book, observe à propos de la synchronicité que, "D'après les écrits de Jung (1981), il est clair que plusieurs facteurs doivent être présents pour qu'un événement soit synchrone. Tout d'abord , il doit y avoir un intérêt pour l'esprit de l'observateur [parallèlement à ce que Weinberg dit que l'observateur et la réalité sont entrelacés], et avec cet intérêt vient un affect accru. L'affect émerge des archétypes, qui sont les principes d'ordre a priori de la nature, les Lorsqu'un archétype est activé, une énergie est mise en mouvement qui n'adhère pas aux lois de la causalité, ou du temps et de l'espace, mais se déplace à sa manière entre le psychisme, ou l'inconscient, et la matière, ou réalité. Jung appelle ce mouvement acausal (1981) ; v
Théorie du chaos - Théorie de la synchronicité ; Le nombre 42 et le sens de la vie + Viktor Frankl & Dr. Wong & Conscience collective auto-organisée - Synchronicité.- Fandom, C Cusack & C Hall - Symbolisme spirituel inconscient+ Spiritual Prism Paradigm
Creators: name: Peck Jr, Charles
Publisher: name: unknown
Year: 2008
Subjects: subject: Paranormal fiction
subject: Coincidence
subject: French literature
subject: Philosophy, French
subject: Painting, French
subject: Precognition
subject: Guénon, René
subject: Chaotic behavior in systems
subject: Jungian psychology

description: La théorie du chaos n'est pas aussi complexe qu'on le prétend souvent Comme l'observe Robert Juliano, le principe sous-jacent est que "dans le caractère aléatoire apparent des systèmes complexes chaotiques, il existe des modèles sous-jacents, des interconnexions, des boucles de rétroaction constantes, la répétition, l'auto-similarité , fractales et auto-organisation.

"Le chaos a été formellement défini par la Royal Society (1986) comme "un comportement stochastique dans un système déterministe" et est donc un système qui, bien qu'affichant un comportement apparemment aléatoire, a un modèle et une légalité sous-jacents !" Comme l'a expliqué Robert Juliano, un expert qui a une "formation en science de la complexité" et qui a "travaillé avec des systèmes dynamiques auto-organisés", "la théorie du chaos est une approche multidisciplinaire de la dynamique des systèmes déterministes, [et] ce qui émerge de eux. La définition du « chaos » par la théorie du chaos est mathématiquement orientée, n'est pas considérée comme universelle et est aussi précise que restrictive. »

Nancy Furlotti, dans son article, Tracing a Red Thread: Synchronicity and Jung's Red Book, observe à propos de la synchronicité que, "D'après les écrits de Jung (1981), il est clair que plusieurs facteurs doivent être présents pour qu'un événement soit synchrone. Tout d'abord , il doit y avoir un intérêt pour l'esprit de l'observateur [parallèlement à ce que Weinberg dit que l'observateur et la réalité sont entrelacés], et avec cet intérêt vient un affect accru. L'affect émerge des archétypes, qui sont les principes d'ordre a priori de la nature, les Lorsqu'un archétype est activé, une énergie est mise en mouvement qui n'adhère pas aux lois de la causalité, ou du temps et de l'espace, mais se déplace à sa manière entre le psychisme, ou l'inconscient, et la matière, ou réalité. Jung appelle ce mouvement acausal (1981) ; v