Enhancing therapy with nano-based delivery systems: exploring the bioactive properties and effects of apigenin
Creators: name: Kumar, Girish
name: Jain, Pushpika
name: Virmani, Tarun
name: Sharma, Ashwani
name: Akhtar, Md Sayeed
name: Aldosari, Saad A
name: Khan, Mohd Faiyaz
name: Duarte, Sofia O D
name: Fonte, Pedro
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Space Science
Medicine
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Apigenin, a potent natural flavonoid, has emerged as a key therapeutic agent due to its multifaceted medicinal properties in combating various diseases. However, apigenin's clinical utility is greatly limited by its poor water solubility, low bioavailability and stability issues. To address these challenges, this review paper explores the innovative field of nanotechnology-based delivery systems, which have shown significant promise in improving the delivery and effectiveness of apigenin. This paper also explores the synergistic potential of co-delivering apigenin with conventional therapeutic agents. Despite the advantageous properties of these nanoformulations, critical challenges such as scalable production, regulatory approvals and comprehensive long-term safety assessments remain key hurdles in their clinical adoption which must be addressed for commercialization of apigenin-based formulations. Apigenin is a natural substance found in plants that might help treat illnesses like cancer, diabetes, heart problems and brain disorders. But it doesn't work very well because it doesn't dissolve in water, is hard for the body to use and isn't very stable. To fix this, scientists are putting apigenin inside tiny carriers called nanocarriers. These tiny carriers help apigenin dissolve better, be absorbed by the body more easily and work better. There are different kinds of nanocarriers, like tiny fat bubbles, tiny solid particles and tiny gels. These can be made to target specific parts of the body, which helps reduce side effects. Apigenin can also be mixed with other medicines in these carriers to work even better. However, there are big challenges in making these treatments widely available, like making enough of them, getting permission from health authorities and making sure they are safe for a long time. This review talks about the latest progress and future possibilities in using nanotechnology to deliver apigenin, aiming to make it better for treating diseases. Unlocking Apigenin full potential: Nanotechnology steps in to overcome delivery challenges, enhancing its effectiveness for clinical use. #Apigenin #NanotechHealth #Nanomedicine Includes a wide range of chemical classes such as polyphenols, alkaloids, terpenoids and flavonoids. Known for their antioxidant, anti-inflammatory, antimicrobial, anticancer and neuroprotective properties. Flavonoids help reduce oxidative stress and inflammation, potentially managing heart disease and cancer. Apigenin, a flavonoid, has significant therapeutic potential due to its antioxidant, anticancer and anti-inflammatory properties. It helps reduce the risk of cardiovascular diseases and treats neurodegenerative disorders. Classified under Class II of the Biopharmaceutical Classification System. Partition coefficient: 2.87; water solubility: 1.35 μg/ml at 25°C. Molecular weight: 270.24 g/mol; melting point: 347.5°C. Limited therapeutic efficacy due to poor bioavailability, low solubility, reduced stability and interactions with other medications. Utilized nanocarriers include liposomes, solid lipid nanoparticles, polymeric nanoparticles, nanogels and more. Nanocarriers improve aqueous solubility, bioavailability, stability, controlled drug release and targeting. Specific targeting enabled by functionalizing nanoparticle surfaces with ligands and polymers. Co-delivery offers synergistic effects, enhanced therapeutic outcomes and minimized toxic effects. Apigenin co-delivered with other drugs shows better therapeutic potential.