cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: ADCO, Cartulaire de l'office de la Porte de l'abbaye de Cîteaux, Registrum possessionum porte Cistercii (début XVe siècle), Cart. 172 (11 H 69), 115 folios, f. 0032
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP

description: Cartulaire de l'office de la Porte de l'abbaye de Cîteaux, Registrum possessionum porte Cistercii (début XVe siècle), Archives départementales de la Côte-d'Or, Cart. 172 (11 H 69), 115 folios, f. 0032, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de l'office de la Porte de l'abbaye de Cîteaux, Registrum possessionum porte Cistercii (début XVe siècle), Archives départementales de la Côte-d'Or, Cart. 172 (11 H 69), 115 folios, f. 0032, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Measurement of $ψ(2S)$ decays to baryon pairs
Creators: name: Bai, J. Z.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: A sample of 3.95M $ψ(2S)$ decays registered in the BES detector are used to study final states containing pairs of octet and decuplet baryons. We report branching fractions for $ψ(2S)\to p\bar{p}$, $Λ\barΛ$, $Σ^0\barΣ{}^0$, $Ξ^-\barΞ{}^+$, $Δ^{++}\barΔ{}^{--}$, $Σ^+(1385)\barΣ{}^-(1385)$, $Ξ^0(1530)\barΞ{}^0(1530)$, and $Ω^-\barΩ{}^+$. These results are compared to expectations based on the SU(3)-flavor symmetry, factorization, and perturbative QCD.
description: 22 pages, 21 figures, 4 tables
CP-PACS Result for the Quenched Light Hadron Spectrum
Creators: name: PACS Collaboration
name: Aoki, S.
name: Boyd, G.
name: Burkhalter, R.
name: Hashimoto, S.
name: Ishizuka, N.
name: Iwasaki, Y.
name: Kanaya, K.
name: Kuramashi, Y.
name: Okawa, M.
name: Ukawa, A.
name: Yoshié, T.
Publisher: name: arXiv
Year: 1997
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: The quenched hadron spectrum in the continuum obtained with the Wilson quark action in recent simulations on the CP-PACS is presented. Results for the light quark masses and the QCD scale parameter are reported.
description: Talk presented by K. Kanaya at Lattice97, Edinburgh
Testing QCD with Hypothetical Tau Leptons
Creators: name: Brodsky, S. J.
name: Pelaez, J. R.
name: Toumbas, N.
Publisher: name: arXiv
Year: 1998
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We construct new tests of perturbative QCD by considering a hypothetical tau lepton of arbitrary mass, which decays hadronically through the electromagnetic current. We can explicitly compute its hadronic width ratio directly as an integral over the e^+ e^- annihilation cross section ratio, R_{e^+e^-}. Furthermore, we can design a set of commensurate scale relations and perturbative QCD tests by varying the weight function away from the form associated with the V-A decay of the physical tau. This method allows the wide range of the R_{e^+e^-} data to be used as a probe of perturbative QCD.
description: 4 pages, 4 figures
Saturation in Diffractive Deep Inelastic Scattering
Creators: name: Golec-Biernat, K.
name: Wusthoff, M.
Publisher: name: arXiv
Year: 1999
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We successfully describe the HERA-data on diffractive deep inelastic scattering using a saturation model which has been applied in our earlier analysis of the inclusive $ep$-scattering data. No further parameters are needed. Saturation already turned out to be essential in describing the transition from large to small values of $Q^2$ in inclusive scattering. It is even more important for diffractive processes and naturally leads to a constant ratio of the diffractive versus inclusive cross sections. We present an extensive discussion of our results as well as detailed comparison with data.
description: 31 pages, 12 figures, replaced with the journal version. A missing factor 1/2 in eq.(39) inserted
Inference under right censoring for transformation models with a change-point based on a covariate threshold
Creators: name: Kosorok, Michael R.
name: Song, Rui
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: We consider linear transformation models applied to right censored survival data with a change-point in the regression coefficient based on a covariate threshold. We establish consistency and weak convergence of the nonparametric maximum likelihood estimators. The change-point parameter is shown to be
Topology without cooling: instantons and monopoles near to deconfinement
Creators: name: Feurstein, M.
name: Ilgenfritz, E. -M.
name: Markum, H.
name: Müller-Preussker, M.
name: Thurner, S.
Publisher: name: arXiv
Year: 1997
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: In an attempt to describe the change of topological structure of pure SU(2) gauge theory near deconfinement a renormalization group inspired method is tested. Instead of cooling, blocking and subsequent inverse blocking is applied to Monte Carlo configurations to capture topological features at a well-defined scale. We check that this procedure largely conserves long range physics like string tension. UV fluctuations and lattice artefacts are removed which otherwise spoil topological charge density and Abelian monopole currents. We report the behaviour of topological susceptibility and monopole current densities across the deconfinement transition and relate the two faces of topology to each other. First results of a cluster analysis are described.
description: 6 pages, 8 figures, LaTeX with espcrc2.sty. Talk and poster presented at Lattice97, Edinburgh, 22-26 July 1997, to appear in Nucl. Phys. B (Proc.Suppl.)
Local photo-mechanical stiffness revealed in gold nanoparticles supracrystals by ultrafast small-angle electron diffraction
Creators: name: Mancini, Giulia Fulvia
name: Pennacchio, Francesco
name: Latychevskaia, Tatiana
name: Reguera, Javier
name: Stellacci, Francesco
name: Carbone, Fabrizio
Publisher: name: arXiv
Year: 2018
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: We demonstrate that highly-ordered two-dimensional crystals of ligand-capped gold nanoparticles display a local photo-mechanical stiffness as high as that of solids such as graphite. In out-of equilibrium electron diffraction experiments, a strong temperature jump is induced in a thin film with a femtosecond laser pulse. The initial electronic excitation transfers energy to the underlying structural degrees of freedom, with a rate generally proportional to the stiffness of the material. With femtosecond small-angle electron diffraction, we observe the temporal evolution of the diffraction feature associated to the nearest-neighbor nanoparticle distance. The Debye-Waller decay for the octanethiol-capped nanoparticles supracrystal, in particular, is found to be unexpectedly fast, almost as fast as the stiffest solid known and observed by the same technique, i.e. graphite. Our observations unravel that local stiffness in a dense supramolecular assembly can be created by Van der Waals interactions up to a level comparable to crystalline systems characterized by covalent bonding.
Chiral Phase Transition for SU(N) Gauge Theories via an Effective Lagrangian Approach
Creators: name: Sannino, F.
name: Schechter, J.
Publisher: name: arXiv
Year: 1999
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the chiral phase transition for vector-like SU(N) gauge theories as a function of the number of quark flavors N_f by making use of an anomaly-induced effective potential. We modify an effective potential of a previous work, suggested for N_f < N, and apply it to larger values of N_f where the phase transition is expected to occur. The new effective potential depends explicitly on the full β-function and the anomalous dimension γof the quark mass operator. By using this potential we argue that chiral symmetry is restored for γ<1. A perturbative computation of γthen leads to an estimate of the critical value N_f^c for the transition.
description: 16 pages, 1 figure, RevTeX
Light Quark Fragmentation in Polarized Z0 Decays at SLD
Creators: name: Kalelkar, M.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We report results on two physics topics from the SLD experiment at the SLAC Linear Collider, using our full sample of 550,000 events of the type e+e- --> Z0 --> q-q(bar). The electron beam was polarized, enabling the quark and antiquark hemispheres to be tagged in each event. One physics topic is the first study of rapidities signed such that positive rapidity is along the quark rather than antiquark direction. Distributions of ordered differences in signed rapidity between pairs of particles are analyzed, providing the first direct observation of baryon number ordering along the q-q(bar) axis. The other topic is the first direct measurement of A_s, the parity-violating coupling of the Z0 to strange quarks, by measuring the left-right forward-backward production asymmetry in polar angle of the tagged s-quark. We obtain A_s = 0.895 +- 0.066(stat.) +- 0.062(syst.), which is consistent with the Standard Model and is currently the most precise measurement of this quantity.
description: 10 pages, 3 figures, to appear in the Proceedings of the International Euroconference on Quantum Chromodynamics (QCD 00), Montpellier, France
Supplementary Methods, Figures and Tables from A range-wide domino effect and resetting of the annual cycle in a migratory songbird
Creators: name: Gow, Elizabeth A.
name: Burke, Lauren
name: Winkler, David W.
name: Knight, Samantha M.
name: Bradley, David W.
name: Clark, Robert G.
name: Bélisle, Marc
name: Berzins, Lisha L.
name: Blake, Tricia
name: Bridge, Eli S.
name: Dawson, Russell D.
name: Dunn, Peter O.
name: Garant, Dany
name: Holroyd, Geoff
name: Horn, Andrew G.
name: Hussell, David J. T.
name: Lansdorp, Olga
name: Laughlin, Andrew J.
name: Leonard, Marty L.
name: Pelletier, Fanie
name: Shutler, Dave
name: Siefferman, Lynn
name: Caz M. Taylor
name: Trefry, Helen
name: Vleck, Carol M.
name: Vleck, David
name: Whittingham, Linda A.
name: D. Ryan Norris
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Latitudinal differences in timing of breeding are well documented but how such differences carry over to influence timing of events in the annual cycle of migratory birds is not well understood. We examined geographical variation in timing of events throughout the year using light-level geolocator tracking data from 133 migratory tree swallows (Tachycineta bicolor) originating from 12 North American breeding populations. A swallow's breeding latitude influenced timing of breeding, which then carried over to affect breeding ground departure. This resulted in subsequent effects on the arrival and departure schedules at fall stopover locations and timing of arrival at non-breeding locations. This ‘domino effect’ between timing events was no longer apparent by the time individuals departed for spring migration. Our range-wide analysis demonstrates the lasting impact breeding latitude can have on migration schedules but also highlights how such timing relationships can reset when individuals reside at non-breeding sites for extended periods of time.
Differential effects of alendronate on chondrocytes, cartilage matrix and subchondral bone structure in surgically induced osteoarthritis in mice
Creators: name: Ehrnsperger, Marianne
name: Taheri, Shahed
name: Pann, Patrick
name: Schilling, Arndt F.
name: Grässel, Susanne
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: DMM, Osteoarthritis, Bisphosphonate, Alendronate, VDIPEN, ADAMTS-5, Subchondral bone, Cartilage, Micro/nano-CT, Osteoclasts, Chondrocytes, NK1-R, MMP-13
subject: 610 Medizin

description: Bisphosphonates (BP) are considered a treatment option for osteoarthritis (OA) due to reduction of OA-induced microtrauma in the bone marrow, stabilization of subchondral bone (SB) layer and pain reduction. The effects of high-dose alendronate (ALN) treatment on SB and articular cartilage after destabilization of the medial meniscus (DMM) or Sham surgery of male C57Bl/6J mice were analyzed. We performed serum analysis; histology and immunohistochemistry to assess the severity of OA and a possible pain symptomatology. Subsequently, the ratio of bone volume to total volume (BV/TV), epiphyseal trabecular morphology and the bone mineral density (BMD) was analyzed by nanoCT. Serum analysis revealed a reduction of ADAMTS5 level. The histological evaluation displayed no protective effect of ALN-treatment on cartilage erosion. NanoCT-analysis of the medial epiphysis revealed an increase of BV/TV in ALN-treated mice. Only the DMM group had significantly higher SB volume accompanied by decreased subchondral bone surface. Furthermore Nano-CT analysis revealed an increase in trabecular density and number, a decreased BMD and reduced osteophyte formation in the ALN mice. ALN treatment affected bone micro-architecture by reducing osteophytosis with simultaneous increasing subchondral bone plate thickness, trabecular thickness and BMD. Accordingly, ALN cannot be considered as a potential treatment strategy in general, however in a subgroup of patients with high bone turnover in an early-stage of OA, ALN might be an option when applied during a restricted time frame.
title: ADCO, Ordre cistercien : comptes (1403-1423) (11 H 1161), f. 00273
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: comptes
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Ordre cistercien : comptes (1403-1423), Archives départementales de la Côte-d'Or, (11 H 1161). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Ordre cistercien : comptes (1403-1423), Archives départementales de la Côte-d'Or, (11 H 1161), f. 00273, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
Phylogenetic Hypotheses for the Monocotyledons Constructed from rbcL Sequence Data
Creators: name: Hills, Harold G.
name: Kress, W. John
name: Duvall, Melvin R.
name: Chase, Mark W.
name: Gaut, Brandon S.
name: Clark, W. Dennis
name: Clegg, Michael T.
name: Eguiarte, Luis E.
name: Smith, James F.
name: Zimmer, Elizabeth A.
name: Learn, Gerald H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: DNA sequences for the plastid locus that encodes the large subunit of ribulose 1,5-bisphosphate carboxylase/oxygenase (rbcL) were determined for 18 species of monocotyledons in 15 families. These data were analyzed together with sequences for 60 other monocot species in a total of 52 families by the maximum likelihood method producing one, presumably optimal, topology. An additional 26 species were added (104 total monocot species) and analyzed by the parsimony method with an outgroup of 18 dicot species producing 109 trees of 3,932 steps. The rbcL data show at least moderate support for seven lineages corresponding to the following orders, superorders, or combinations: Arecanae; Asparagales (excluding Hypoxidaceae) plus Iridaceae; Cyclanthanae plus Pandananae; Dioscoreales; Orchidales; Typhales; and Zingiberanae. Six clades corresponding to families or genera are well supported, including: Agavaceae, Asphodelaceae, Bromeliaceae, Hypoxidaceae, Poaceae, and Tradescantia. The two, earliest diverging multispecies clades in our rbcL phylogenies, Alismatanae and Aranae, are only weakly supported, and Bromelianae, Commelinanae, and Lilianae are paraphyletic. In all analyses Acorus calamus is phylogenetically isolated as the sister species to the remaining species of monocotyledons.
Chiral symmetry and the Delta-Nucleon transition form factors
Creators: name: Gellas, G. C.
name: Hemmert, T. R.
name: Ktorides, C. N.
name: Poulis, G. I.
Publisher: name: arXiv
Year: 1998
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The three complex form factors entering the $Δ\to Nγ^\ast$ vertex are calculated to ${\cal O}(ε^3)$ in the framework of a chiral effective theory with explicit Δ(1232) degrees of freedom included. It is shown that the low q^2 behavior of the form factors is governed by $πN$, $πΔ$ loop effects. Predictions are given for the q^2-dependence of the three transition-multipoles $M1(q^2), E2(q^2), C2(q^2)$. Furthermore, the role of presently unknown low energy constants that affect the values of the multipole ratios EMR(q^2) and CMR(q^2) is elucidated.
description: 37 pages, 12 figures
HIF Transcription Factor Expression and Induction of Hypoxic Response Genes in a Retroperitoneal Angiosarcoma
Creators: name: Simon, M Celeste
name: Vaughn, David J
name: Rathmell, W Kimryn
name: Acs, Geza
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Angiosarcoma is a rare and highly aggressive tumor of endothelial origin. The molecular mechanisms driving angiosarcoma growth have not been fully elucidated, although autocrine stimulation by vascular endothelial growth factor (VEGF) secretion may play a role in the pathogenesis of this tumor. We identified a patient with a very rare form of angiosarcoma arising from the retroperitoneum. Immunohistochemical analysis demonstrated widespread up-regulation of the hypoxic response pathway as a mechanism of enhanced VEGF expression. Disordered regulation of the hypoxic response pathway can result in the expression of factors such as VEGF and erythropoietin, which may promote autocrine tumor growth in angiosarcoma.
Computer Modeling of Personal Autonomy and Legal Equilibrium
Creators: name: Sheliazhenko, Yurii
Publisher: name: arXiv
Year: 2018
Subjects: subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences
subject: F.1.1; I.6.5
subject: 68Q05, 93A30

description: Empirical studies of personal autonomy as state and status of individual freedom, security, and capacity to control own life, particularly by independent legal reasoning, are need dependable models and methods of precise computation. Three simple models of personal autonomy are proposed. The linear model of personal autonomy displays a relation between freedom as an amount of agent's action and responsibility as an amount of legal reaction and shows legal equilibrium, the balance of rights and duties needed for sustainable development of any community. The model algorithm of judge personal autonomy shows that judicial decision making can be partly automated, like other human jobs. Model machine learning of autonomous lawyer robot under operating system constitution illustrates the idea of robot rights. Robots, i.e. material and virtual mechanisms serving the people, deserve some legal guarantees of their rights such as robot rights to exist, proper function and be protected by the law. Robots, actually, are protected as any human property by the wide scope of laws, starting with Article 17 of Universal Declaration of Human Rights, but the current level of human trust in autonomous devices and their role in contemporary society needs stronger legislation to guarantee the robot rights.
description: 8 pages, 6 figures, presented at Computer Science On-line Conference 2018
Enhancement of chemotherapy using oncolytic virotherapy: Mathematical and optimal control analysis
Creators: name: Malinzi, Joseph
name: Ouifki, Rachid
name: Eladdadi, Amina
name: Torres, Delfim F. M.
name: White, K. A. Jane
Publisher: name: arXiv
Year: 2018
Subjects: subject: Optimization and Control (math.OC)
subject: Cell Behavior (q-bio.CB)
subject: FOS: Mathematics
subject: FOS: Biological sciences
subject: 49K15, 92B05

description: Oncolytic virotherapy (OV) has been emerging as a promising novel cancer treatment that may be further combined with the existing therapeutic modalities to enhance their effects. To investigate how OV could enhance chemotherapy, we propose an ODE based model describing the interactions between tumour cells, the immune response, and a treatment combination with chemotherapy and oncolytic viruses. Stability analysis of the model with constant chemotherapy treatment rates shows that without any form of treatment, a tumour would grow to its maximum size. It also demonstrates that chemotherapy alone is capable of clearing tumour cells provided that the drug efficacy is greater than the intrinsic tumour growth rate. Furthermore, OV alone may not be able to clear tumour cells from body tissue but would rather enhance chemotherapy if viruses with high viral potency are used. To assess the combined effect of OV and chemotherapy we use the forward sensitivity index to perform a sensitivity analysis, with respect to chemotherapy key parameters, of the virus basic reproductive number and the tumour endemic equilibrium. The results from this sensitivity analysis indicate the existence of a critical dose of chemotherapy above which no further significant reduction in the tumour population can be observed. Numerical simulations show that a successful combinational therapy of the chemotherapeutic drugs and viruses depends mostly on the virus burst size, infection rate, and the amount of drugs supplied. Optimal control analysis was performed, by means of Pontryagin's principle, to further refine predictions of the model with constant treatment rates by accounting for the treatment costs and sides effects.
description: This is a preprint of a paper whose final and definite form is with 'Mathematical Biosciences and Engineering', ISSN 1551-0018 (print), ISSN 1547-1063 (online), available at [http://www.aimsciences.org/journal/1551-0018]. Submitted 27-March-2018; revised 04-July-2018; accepted for publication 10-July-2018
Raloxifene and Selective Cell Cycle Specific Agents: A Case for the Inclusion of Raloxifene in Current Breast Cancer Treatment Therapies
Creators: name: Southerland, William M
name: Bowen, Donnell
name: Green, Sidney
name: Desoto, JA
name: Davis, JH
name: Fryar-Tita, Elizabeth B
name: Das, Jharna R
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: BACKGROUND: Breast cancer patients are at increased risk of osteoporosis. Contributing factors include age and/or chemotherapy. The selective estrogen modulator, raloxifene (RAL), effective in the prevention of breast cancer and approved for the treatment and prevention of osteoporosis, may prove beneficial in current breast cancer treatment modules. The purpose of this study was to evaluate RAL in combination with 5-fluorouracil (5-FU) and trimetrexate (TMX) to determine the most effective sequence in which to administer these cell cycle specific agents while taking into consideration the cellular mechanism of action. The goal was to maintain cytotoxicity to breast cancer cells and capitalize on the selective estrogen receptor modulatory effects of RAL.

MATERIALS AND METHODS: MCF-7 cells were exposed to (i) TMX, 5-FU or RAL alone, or (ii) RAL 24 h prior to 5-FU followed 2 h later by TMX, or (iii) 5-FU 2 h prior to TMX followed 24 h later by RAL. The cell viability was determined using the Quick Cell Proliferation Assay.

RESULTS: The growth rate of MCF- 7 cells exposed to early RAL was 68.25 +/- 4.11% that of the control, however, late RAL exposure produced a growth of 34.75 +/- 4.79% that of the control. Late RAL maintained the cytotoxicity of the regimen. The findings were further supported by cell flow cytometry and Western blot analysis data.

CONCLUSION: RAL given prior to 5-FU/TMX significantly compromised cytotoxicity to breast cancer cells.
Study of the chiral behavior of [the chiral condensate] in quenched QCD
Creators: name: Kaehler, Adrian L.
Publisher: name: arXiv
Year: 1997
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: The QCD phase transition is studied on 32^3x8 quenched lattices. One expects from simple arguments that the quenched chiral condensate should diverge as the chiral limit is approached. Previous studies have not been able to observe this behavior, perhaps due to relatively large lattice spacings used. The topic is revisited here on N_t=8 lattices, where the physical spacing is approximately 2(Gev^-1).
description: 3 pages, 1 figure
Sequence-dependent Administration of Raloxifene and 5-Fluorouracil/Pemetrexed Protects against Pemetrexed Cytotoxicity in Human Bone Marrow
Creators: name: Green, Sidney
name: Southerland, William M
name: Fryar-Tita, Elizabeth B
name: Bowen, Donnell
name: Das, Jharna R
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: BACKGROUND: Pemetrexed (Alimta) is a new-generation multitargeted antifolate that inhibits several key enzymes in the de novo pathways of pyrimidine and purine biosynthesis, including thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT). Alimta has demonstrated antitumor activity in a broad array of human malignancies, e.g. breast, non-small cell lung cancer, malignant pleural mesothelioma and pancreatic, colorectal, gastric, bladder, head and neck cancer, and is currently in phase III clinical trials. It has been reported that a dose of 600 mg/m2 of pemetrexed showed toxicity to bone marrow and the gastrointestinal system. The aim of this investigation was to evaluate raloxifene (RAL) in combination with 5-fluorouracil (5-FU)/pemetrered multitargeted antifolate (MTA) to determine the most effective regimens and cellular mechanism of action to mitigate pemetrexed cytotoxicity in human bone marrow cells.

MATERIALS AND METHODS: In order to determine the sequence-dependent interaction between MTA, 5-FU and RAL on proliferation, cell viability was carried out using the Quick Cell Proliferation Assay by exposing the HS-5 and MCF-7 cells to (i) MTA, 5-FU and RAL alone, or (ii) RAL 24 h prior to 5-FU followed 2 h later by MTA, or (iii) 5-FU 2 h prior to MTA followed 24 h later by RAL.

RESULTS: The growth rate in MCF-7 in early RAL was 69 +/- 8.65% and late RAL was 36 +/- 4.6% of the control whereas in bone marrow early RAL was 78 +/- 8.65% and late RAL was 52 +/- 5.49% of the control. The late RAL exhibits significant protection against MTA cytotoxicity in bone marrow. The findings were further supported by cell flow cytometry, apoptosis and Western blot analysis data.

CONCLUSION: This study suggests that sequence-dependent administration of RAL (5FU/MTA/RAL), in combination with 5-FU/MTA, protects against MTA toxicity in human bone marrow while maintaining the maximum inhibitory effect of pemetrexed in breast cancer.
Development of rf reference line for the linear collider
Creators: name: Naito, T.
name: Ebihara, K.
name: Hayano, H.
name: Urakawa, J.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The rf distribution system for the linear collider requires stable x-band(11.424GHz) rf phase signal over 25km length. In order to realize the distribution system, a fiber optic link using a phase stabilized optical fiber was tested. The phase stabilized optical fiber has been employed at LEP, KEKB, etc.. This paper describes the hardware system and result of the preliminary test of the feed back system for stabilization of the phase change.
description: LINAC2000 THA04
Extracting |V_{ub}| from the inclusive charmless semileptonic branching ratio of b hadrons
Creators: name: Jin, Changhao
Publisher: name: arXiv
Year: 1998
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We calculate the inclusive charmless semileptonic decay width of the B meson using a QCD-based approach. This approach is able to account for both dynamic and kinematic effects of nonperturbative QCD. The charmless semileptonic decay width is found to be enhanced by long-distance strong interactions by +(7\pm 5)% with respect to the free quark decay width. Using the resulting theoretical value for the charmless semileptonic decay width, an extraction of $|V_{ub}|$ is made from the measured lifetime and inclusive charmless semileptonic branching ratio of b hadrons.
description: 9 pages, 3 ps figures, revised version to appear in PLB, minor changes in the numerical results
Molecular gas filaments and star-forming knots beneath an X-ray cavity in RXC J1504-0248
Creators: name: Vantyghem, A. N.
name: McNamara, B. R.
name: Russell, H. R.
name: Edge, A. C.
name: Nulsen, P. E. J.
name: Combes, F.
name: Fabian, A. C.
name: McDonald, M.
name: Salome, P.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present recent ALMA observations of the CO(1-0) and CO(3-2) emission lines in the brightest cluster galaxy of RXCJ1504.1$-$0248, which is one of the most extreme cool core clusters known. The central galaxy contains $1.9\times 10^{10}~M_{\odot}$ of molecular gas. The molecular gas morphology is complex and disturbed, showing no evidence for a rotationally-supported structure in equilibrium. $80\%$ of the gas is situated within the central 5 kpc of the galactic center, while the remaining gas is located in a 20 kpc long filament. The cold gas has likely condensed out of the hot atmosphere. The filament is oriented along the edge of a putative X-ray cavity, suggesting that AGN activity has stimulated condensation. This is enegetically feasible, although the morphology is not as conclusive as systems whose molecular filaments trail directly behind buoyant radio bubbles. The velocity gradient along the filament is smooth and shallow. It is only consistent with free-fall if it lies within $20^{\circ}$ of the plane of the sky. The abundance of clusters with comparably low velocities suggests that the filament is not free-falling. Both the central and filamentary gas are coincident with bright UV emission from ongoing star formation. Star formation near the cluster core is consistent with the Kennicutt-Schmidt law. The filament exhibits increased star formation surface densities, possibly resulting from either the consumption of a finite molecular gas supply or spatial variations in the CO-to-H$_2$ conversion factor.
description: 15 pages, 10 figures, accepted in ApJ
Correlation effects in ionic crystals: I. The cohesive energy of MgO
Creators: name: Doll, Klaus
name: Dolg, Michael
name: Fulde, Peter
name: Stoll, Hermann
Publisher: name: arXiv
Year: 1995
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: High-level quantum-chemical calculations, using the coupled-cluster approach and extended one-particle basis sets, have been performed for (Mg2+)n (O2-)m clusters embedded in a Madelung potential. The results of these calculations are used for setting up an incremental expansion for the correlation energy of bulk MgO. This way, 96% of the experimental cohesive energy of the MgO crystal is recovered. It is shown that only 60% of the correlation contribution to the cohesive energy is of intra-ionic origin, the remaining part being caused by van der Waals-like inter-ionic excitations.
description: LaTeX, 20 pages, no figures
Additional file 7: of Examining trends in inequality in the use of reproductive health care services in Ghana and Nigeria
Creators: name: Oluwasegun Ogundele
name: Pavlova, Milena
name: Groot, Wim
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: Figure S6. Concentration curves of use of delivery care, Nigeria (Years 2003, 2008, 2013). (PDF 393 kb)
IGF-I Receptor Inhibition Combined with Rapamycin or Temsirolimus Inhibits Neuroblastoma Cell Growth
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: BACKGROUND: Neuroblastoma is the third most common solid tumor in children. Treatment continues to be challenging. The pathogenesis of neuroblastoma has been related to expression of the type 1 insulin-like growth factor receptor (IGF1R) and to transcription factor MYC-N amplification. Previous studies have shown that MYC-N expression is disrupted by blockade of the IGF1R with a specific monoclonal antibody, alphaIR3. Inhibition of IGF1R signaling can be accomplished by other agents, including rapamycin or temsirolimus, which target mTOR (mammalian target of rapamycin).

MATERIALS AND METHODS: BE-2(c) and IMR-32 neuroblastoma cell lines were treated with varying concentrations of alphaIR3, rapamycin and temsirolimus alone or in combination and the viable cells were counted.

RESULTS: Blockade of IGF1R signaling significantly inhibited cell growth as compared to untreated controls (p < 0.05), and a combination of agents was more effective than each agent alone.

CONCLUSION: The combination of rapamycin or temsirolimus with alphaIR3 blocks the IGF1R signaling pathway and has an antiproliferative effect on neuroblastoma cells warranting further investigations using inhibitors of IGF1R signaling as novel combination therapy for neuroblastoma.
OPeNDAP and the Data Access Protocol (DAP)
Creators: name: Gallagher, James
name: Fulker, David
Publisher: name: Zenodo
Year: 2023

description: Summary of OPeNDAP and the Data Access Protocol (DAP) Presentation

Introduction:

OPeNDAP is a non-profit organization that develops and supports DAP, a web service protocol for data access.

DAP is used by hundreds of data providers and employed in various analysis software.

NASA considers DAP2 a "Community Standard".

Concept:

Clients retrieve specific portions of data using URLs with query strings.

Responses come in two types: metadata (descriptions) and content (values).

Applications like MATLAB and APIs like the netCDF library can work with DAP data seamlessly.

Key Features:

Focuses on scientific data: Often involves geospatial maps and multi-dimensional coordinates.

Server-side processing: Servers can aggregate, enrich, and translate data.

Simple data model: Few data types for easier programming and broader applicability.

Subset and transformation: Users can select specific data and apply functions through queries.

Data translation: Many servers accept and present data in various formats.

Overall, OPeNDAP and DAP provide a flexible and efficient way to access and manipulate scientific data on the web.
Elevated ERCC1 Gene Expression in Blood Cells Associated with Exposure to Arsenic from Drinking Water in Inner Mongolia
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: BACKGROUND: Chronic arsenic exposure has been associated with human cancer. The objective of this study was to investigate the effects of arsenic exposure on a DNA nucleotide excision repair gene, ERCC1, expression in human blood cells.

PATIENTS AND METHODS: Water and toenail samples were collected from a total of 327 Inner Mongolian residents for arsenic analysis. Blood samples were collected to determine mRNA expression levels by real-time PCR.

RESULTS: The mRNA levels of ERCC1 expression were positively associated with water arsenic concentration (slope=0.313, p=0.0043) and nail arsenic concentration (slope=0.474, p=0.0073). mRNA levels of ERCC1 expression were significantly correlated with those of OGG1, a base pair excision repair gene (r=0.275, p<0.0001).

CONCLUSION: The results showed that mRNA levels of ERCC1 expression were significantly associated with arsenic concentrations in drinking water, implicating the DNA repair response was induced by arsenic exposure.
Four-wave mixing in a silicon microring resonator using a self-pumping geometry
Creators: name: Massara, M. Previde
name: Sabattoli, F. A.
name: Pirzio, F.
name: Galli, M.
name: Bajoni, D.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Physics (quant-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We report on four-wave mixing in a silicon microring resonator using a self-pumping scheme instead of an external laser. The ring resonator is inserted in an external-loop cavity with a fibered semiconductor amplifier as a source of gain. The silicon microring acts as a filter and we observe lasing in one of the microring's resonances. We study correlations between signal and idler generated beams using a Joint Spectral Density experiment.
Submacropulse Electron-Beam Dynamics Correlated With Higher-Order Modes In Tesla-Type Superconducting RF Cavities
Creators: name: Lumpkin, A. H.
name: Thurman-Keup, R.
name: Edstrom, D.
name: Ruan, J.
name: Eddy, N.
name: Prieto, P.
name: Napoly, O.
name: Carlsten, B. E.
name: Bishofberger, K.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: We report the direct observations of sub-macropulse beam centroid oscillations correlated with higher order modes (HOMs) which were generated by off-axis electron beam steering in TESLA-type superconducting RF cavities. The experiments were performed at the Fermilab Accelerator Science and Technology (FAST) facility using its unique configuration of a photocathode rf gun injecting beam into two separated 9-cell cavities in series with corrector magnets and beam position monitors (BPMs) located before, between, and after them. Oscillations of ~100 kHz in the vertical plane and ~380 kHz in the horizontal plane with up to 600-μm amplitudes were observed in a 3-MHz micropulse repetition rate beam with charges of 100, 300, 500, and 1000 pC/b. However, the effects were much reduced at 100 pC/b. The measurements were based on HOM detector circuitry targeting the first and second dipole passbands, rf BPM bunch-by-bunch array data, imaging cameras, and a framing camera. Calculations reproduced the oscillation frequencies of the phenomena in the vertical case. In principle, these fundamental results may be scaled to cryomodule configurations of major accelerator facilities.
description: 17 pp
Inhibition of IGF-I Receptor Signaling in Combination with Rapamycin or Temsirolimus Increases MYC-N Phosphorylation
Creators: name: Coulter, Don W
name: Moats-Staats, Billie M
name: Wilkie, Mary Beth
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: BACKGROUND: It has been previously shown that blockade of the type 1 insulin-like growth factor receptor (IGF1R) signaling combined with mTOR inhibition decreased neuroblastoma proliferation in vitro. MYC-N inactivation occurs through phosphorylation by downstream elements of the IGF1R signaling pathway. It was hypothesized that inhibition of IGF1R signaling would increase the inactivation of MYC-N.

MATERIALS AND METHODS: BE-2(c) and IMR-32 neuroblastoma cell lines were treated with varying concentrations of alphaIR3, rapamycin and temsirolimus either alone or in combination and the expression of MYC-N and phosphorylated MYC-N proteins were evaluated by Western blotting. The number of apoptotic cells was evaluated through cleaved caspase-3 expression.

RESULTS: IGF1R signaling blockade in combination with mTOR inhibition decreased MYC-N protein expression, increased MYC-N phosphorylation and significantly increased cleaved caspase-3 expression in treated cells.

CONCLUSION: The combination of rapamycin or temsirolimus with alphaIR3 decreases MYC-N expression, increases MYC-N phosphorylation and induces apoptosis in vitro which may have clinical relevance to children with neuroblastoma.
KineCluE: a Kinetic Cluster Expansion code to compute transport coefficients beyond the dilute limit
Creators: name: Schuler, T.
name: Messina, L.
name: Nastar, M
Publisher: name: arXiv
Year: 2018
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: This paper introduces the KineCluE code that implements the self-consistent mean-field theory for clusters of finite size. Transport coefficients are obtained as a sum over cluster contributions (in a cluster expansion formalism), each being individually computed with KineCluE. This method allows for the calculation of these coefficients beyond the infinitely dilute limit, and is an important step in bridging the gap between dilute and concentrated approaches. Inside a finite volume of space containing the components of a given cluster, all kinetic trajectories are accounted for in an exact manner. The code, written in Python, adapts to a wide variety of systems, with various crystallographic structures (possibly under strain), defects and solute amount and types, and various jump mechanisms, including collective ones. The code also features a set of useful tools, such as the sensitivity study routine that allows for the identification of the most important jump frequencies to get accurate transport coefficients with minimum computational cost.
description: Code is available upon request
Additional file 5: of Examining trends in inequality in the use of reproductive health care services in Ghana and Nigeria
Creators: name: Oluwasegun Ogundele
name: Pavlova, Milena
name: Groot, Wim
Publisher: name: figshare
Year: 2018
Subjects: subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: Figure S4. Concentration curves of use of Antenatal care, Nigeria (Years 2003, 2008, 2014). (PDF 1208 kb)
In vivo selection for transmissible drug resistance in Salmonella typhi during antimicrobial therapy
Creators: name: Gilligan, PH
name: Hoge, CW
name: Crawford, RA
name: Morris, JG
name: Schwalbe, RS
name: O'hanlon, PN
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: We report the recovery of Salmonella typhi that acquired resistance to ampicillin, chloramphenicol, trimethoprim-sulfamethoxazole, and gentamicin subsequent to multiple antibiotic therapy. Escherichia coli and Klebsiella pneumoniae isolates which were recovered from the same stool sample displayed identical resistance patterns. Agarose gel electrophoresis revealed that S. typhi and laboratory-derived transconjugants contained a high-molecular-weight plasmid present in the resistant intestinal bacteria.We report the recovery of Salmonella typhi that acquired resistance to ampicillin, chloramphenicol, trimethoprim-sulfamethoxazole, and gentamicin subsequent to multiple antibiotic therapy. Escherichia coli and Klebsiella pneumoniae isolates which were recovered from the same stool sample displayed identical resistance patterns. Agarose gel electrophoresis revealed that S. typhi and laboratory-derived transconjugants contained a high-molecular-weight plasmid present in the resistant intestinal bacteria.
Heavy-Light Decay Constants from Wilson and Static Quarks
Creators: name: Bernard, C.
name: DeGrand, T.
name: DeTar, C.
name: Gottlieb, Steven
name: Heller, U. M.
name: Hetrick, J.
name: McNeile, C.
name: Rummukainen, K.
name: Sugar, R.
name: Toussaint, D.
name: Wingate, M.
Publisher: name: arXiv
Year: 1997
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: MILC collaboration results for \fB, \fBs, \fD, \fDs and their ratios are presented. These results are still preliminary, but the analysis is close to being completed. Sources of systematic error, both within the quenched approximation and from quenching itself, are estimated. We find, for example, $f_B=153\pm 10 {}^{+36}_{-13} {}^{+13}_{-0} MeV$, and $f_{B_s}/f_B = 1.10 \pm 0.02 {}^{+0.05}_{-0.03} {}^{+0.03}_{-0.02}$, where the errors are statistical, systematic (within the quenched approximation), and systematic (of quenching), respectively. The extrapolation to the continuum and the chiral extrapolation are the largest sources of error. Present central values are based on linear chiral extrapolations; a shift to quadratic extrapolations would raise $f_B$ by $\approx20$ MeV and make the error within the quenched approximation more symmetric.
description: 3 pages, LaTeX with espcrc2.sty and epsf.tex, 1 included postscript figure. Poster presented by C. Bernard at LATTICE '97, Edinburgh, 22-26 July 1997
Analyzing P300 Distractors for Target Reconstruction
Creators: name: McDaniel, Jonathan R.
name: Gordon, Stephen M.
name: Solon, Amelia J.
name: Lawhern, Vernon J.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Neurons and Cognition (q-bio.NC)
subject: FOS: Biological sciences

description: P300-based brain-computer interfaces (BCIs) are often trained per-user and per-application space. Training such models requires ground truth knowledge of target and non-target stimulus categories during model training, which imparts bias into the model. Additionally, not all non-targets are created equal; some may contain visual features that resemble targets or may otherwise be visually salient. Current research has indicated that non-target distractors may elicit attenuated P300 responses based on the perceptual similarity of these distractors to the target category. To minimize this bias, and enable a more nuanced analysis, we use a generalized BCI approach that is fit to neither user nor task. We do not seek to improve the overall accuracy of the BCI with our generalized approach; we instead demonstrate the utility of our approach for identifying target-related image features. When combined with other intelligent agents, such as computer vision systems, the performance of the generalized model equals that of the user-specific models, without any user specific data.
description: 4 pages, 3 figures
SSOR Preconditioning of Improved Actions
Creators: name: Eicker, N.
name: Bietenholz, W.
name: Frommer, A.
name: Hoeber, H.
name: Lippert, Th.
name: Schilling, K.
Publisher: name: arXiv
Year: 1997
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We generalize local lexicographic SSOR preconditioning for the Sheikholeslami-Wohlert improved Wilson fermion action and the truncated perfect free fermion action. In our test implementation we achieve performance gains as known from SSOR preconditioning of the standard Wilson fermion action.
description: 3 pages, Latex, 3 figures, Talk presented at Lattice'97