cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Involvement of the disulfidptosis-related immune checkpoint gene, CD276, in glioblastoma malignant phenotype and poor prognosis
Creators: name: Zhuo, Jianwei
name: Zhang, Jing
name: Xu, Yinong
name: Ji, Meng
name: Shen, Haitao
name: Cui, Gang
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer

description: Immunotherapy has promise for glioblastoma multiforme (GBM) treatment and disulfidptosis, a form of cell death involving disintegration of the actin cytoskeleton, is a potential target. The aim of the current study was to identify genes associated with disulfidptosis-related immune checkpoints in GBM and to analyze connections with malignancy. Two expression matrices from The Cancer Genome Atlas-Genotype Tissue Expression (TCGA-GTEx) and Chinese Glioma Genome Atlas (CGGA) cyber public data were utilized to analyze differentially expressed genes (DEGs) in GBM and interaction networks for DEG-coded proteins constructed with protein-protein interaction network analysis. Functional annotation was conducted to indicate DEG function. Hub genes were identified by machine-learning, using Least Absolute Shrinkage and Selection Operator (LASSO) and Support Vector Machine Recursive Feature Elimination (SVM-RFE). Gene expression, immune cell composition and single-cell expression were assessed via bioinformatics and in vitro assays. Finally, xenograft nude mouse models were constructed for in vivo validation. 35 DEGs were found in the TCGA-GTEx and 13 in the CGGA databases and linked to immune regulation and GBM progression. The key gene CD276 was screened by bioinformatics methods. CD276 had higher expression in GBM tissues than in control and was higher expression in GBM strain than in normal astrocytes. In vitro CD276 knockdown reduced GBM cell malignancy. Furthermore, CD276 knockdown suppressed tumor growth in vivo. CD276 was the most significant hub gene involved in disulfidptosis and immune checkpoints in GBM. Anti-CD276 therapy may have promise for GBM treatment.
The nature of noise fear in domestic dogs
Creators: name: Iimura, Kumiko
Publisher: name: University of Lincoln
Year: 2024
Subjects: D300 - Animal science
D328 - Animal welfare

description: Noise fear is widely recognised as one of the most common behaviour problems in domestic dogs. Managing noise fear poses several challenges. However, little is known about the aetiology of this problem. This study aimed to progress on understanding of the causes of canine noise fear problems, which might contribute to future treatment research.In this thesis, a web-based survey was employed to investigate the aetiology of canine noise fear. First, in the study of risk-factors within the world population (N=3516), the presence of other dogs in the house, age of the dog, source, breed, country of residence and sex of the dog were found to be demographic risk factors. Significant risk factors regarding development were a previous traumatic experience associated with loud noises and a lack of exposure to engines. Most of these risk factors were also found in the UK and USA subpopulations, suggesting the risk factors above appear to be general regardless of country.Although a previous traumatic experience was found to be one of the risk factors in canine noise fear, more than half of the owners of a dog with noise fear (60%) did not report that their dog had previously had a traumatic experience associated with loud noises before fear developed. This suggested other processes of development of noise fear in the absence of traumatic association, as is suggested in human literature (i.e. social transmission of fear from other fearful animals, a lack of habituation, sensitisation and stress-induced dishabituation). This study did not find evidence to support social transmission of human fear, but evidence of varying strength was found for the other processes. The analysis of sensitisation and acute onset process suggested that different mechanisms of development might lead to different behavioural responses to the same stimulus in dogs, i.e. sensitisation may tend to lead to anxiety of loud noises whereas acute onset may tend to lead to more overt fear of loud noises.Finally, the relationship between the development of noise fear and treatment success was investigated. The analysis of stimulus flooding showed a moderately significant association between sensitisation and treatment success. Further examination is necessary of the relationship between the aetiology and the outcome of treatment of noise fear.
Correcting Estimation Bias in Randomized Clinical Trials With a Test of Treatment-by-Biomarker Interaction
Creators: name: Kiichiro Toyoizumi
name: Matsui, Shigeyuki
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 60506 Virology

description: The key elements in recent drug development aiming toward personalized medicine involve the development of baseline predictive biomarkers to predict the responsiveness to new treatments. When biological evidence to support the biomarker hypothesis is not strong, it is particularly important to evaluate the clinical validity of a predictive biomarker based on data from clinical trials. All-comers randomized clinical trials stratified with biomarker measurements can provide the opportunity to evaluate the predictive value of the biomarker, and a test of treatment-by-biomarker interaction is applied for this purpose. If the interaction is significant, it is natural to proceed to a subgroup analysis that evaluates treatment efficacy within biomarker-based subgroups. However, estimation bias can arise when using the standard estimation method without regard to the significant interaction because of the correlation between the interaction test and subgroup analysis. In this paper, after evaluating the bias function for the standard estimators, we provide bias-corrected point and interval estimation methods, including polynomial approximations of the bias function previously developed for a fallback analysis plan. The magnitude of bias reduction and precision of the proposed estimators are assessed via simulations. Applications to biomarker-stratified, randomized phase III trials in oncology are provided. Supplementary materials for this article are available online.
Artefacts in semivolatile organic compound sampling with polyurethane foam (PUF) substrates in high volume cascade impactors
Creators: name: Galarneau, Elisabeth
name: Patel, Megha
name: Brook, Jeffrey R.
name: Charland, Jean-Pierre
name: Glasius, Marianne
name: Bossi, Rossana
name: Hung, Hayley
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 60506 Virology

description: Polyurethane foam (PUF) is known to sorb gas-phase semivolatile organic compounds (SVOCs) from ambient air and is used routinely in conventional high volume filter-sorbent sampling of such pollutants. PUF rings have also been employed as impaction substrates in a high volume cascade impactor (HVCI) used as a sampler for the evaluation of particle toxicity. Though non-volatile particles (e.g., trace metals, inorganic ions) have been the primary focus, the sampler has also been used to measure particulate SVOC concentrations in ambient air. The aim of this work is to investigate the validity of the latter approach. The results of three sets of experiments conducted in Canada and Denmark are reported herein. Model compounds included native and deuterated polycyclic aromatic hydrocarbons (PAHs). The experiments demonstrated that HVCI PUF substrates sorb gas-phase PAH compounds and that the sorbed mass is subject to mobilization through and out of the sampler. Particulate concentrations of low molecular weight and volatile PAHs are therefore prone to overestimation in samples that have been analysed after extraction of whole PUF substrates. Sonication of collected particles in water before solvent extraction is effective at dislodging them from the PUF but also acts to redistribute their originally particulate PAH mass back to the PUF and to the sonication water. As a result, the PAH content of particles measured after sonication and subsequent filtration does not accurately represent their true values. These artefacts affect not only measured PAH concentrations but also the results of toxicological assays that are conducted to test the characteristics of particles collected using HVCI PUF samplers.
Zur Feinmorphologie letzteiszeitliche Ablagerungen des Rheingletschers in Württemberg
Creators: name: German, Rüdiger
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1958

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 113, 1958
The nature of noise fear in domestic dogs
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: D300 - Animal science
D328 - Animal welfare

description: Noise fear is widely recognised as one of the most common behaviour problems in domestic dogs. Managing noise fear poses several challenges. However, little is known about the aetiology of this problem. This study aimed to progress on understanding of the causes of canine noise fear problems, which might contribute to future treatment research.In this thesis, a web-based survey was employed to investigate the aetiology of canine noise fear. First, in the study of risk-factors within the world population (N=3516), the presence of other dogs in the house, age of the dog, source, breed, country of residence and sex of the dog were found to be demographic risk factors. Significant risk factors regarding development were a previous traumatic experience associated with loud noises and a lack of exposure to engines. Most of these risk factors were also found in the UK and USA subpopulations, suggesting the risk factors above appear to be general regardless of country.Although a previous traumatic experience was found to be one of the risk factors in canine noise fear, more than half of the owners of a dog with noise fear (60%) did not report that their dog had previously had a traumatic experience associated with loud noises before fear developed. This suggested other processes of development of noise fear in the absence of traumatic association, as is suggested in human literature (i.e. social transmission of fear from other fearful animals, a lack of habituation, sensitisation and stress-induced dishabituation). This study did not find evidence to support social transmission of human fear, but evidence of varying strength was found for the other processes. The analysis of sensitisation and acute onset process suggested that different mechanisms of development might lead to different behavioural responses to the same stimulus in dogs, i.e. sensitisation may tend to lead to anxiety of loud noises whereas acute onset may tend to lead to more overt fear of loud noises.Finally, the relationship between the development of noise fear and treatment success was investigated. The analysis of stimulus flooding showed a moderately significant association between sensitisation and treatment success. Further examination is necessary of the relationship between the aetiology and the outcome of treatment of noise fear.
Die Lias-Keuper-Grenze an der Fils bei Göppingen
Creators: name: Groschopf, Paul
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1958

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 113, 1958
title: 1956-1957_LE CALLENNEC Paul_Un silo à blé
Creators: name: Le Callennec, Paul
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Diplôme d'architecte

description: Prix du meilleur diplôme décerné par la SADG.
Correcting Estimation Bias in Randomized Clinical Trials with a Test of Treatment-by-Biomarker Interaction
Creators: name: Kiichiro Toyoizumi
name: Matsui, Shigeyuki
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 60506 Virology

description: The key elements in recent drug development aiming toward personalized medicine involve the development of baseline predictive biomarkers to predict the responsiveness to new treatments. When biological evidence to support the biomarker hypothesis is not strong, it is particularly important to evaluate the clinical validity of a predictive biomarker based on data from clinical trials. All-comers randomized clinical trials stratified with biomarker measurements can provide the opportunity to evaluate the predictive value of the biomarker, and a test of treatment-by-biomarker interaction is applied for this purpose. If the interaction is significant, it is natural to proceed to a subgroup analysis that evaluates treatment efficacy within biomarker-based subgroups. However, estimation bias can arise when using the standard estimation method without regard to the significant interaction because of the correlation between the interaction test and subgroup analysis. In this paper, after evaluating the bias function for the standard estimators, we provide bias-corrected point and interval estimation methods, including polynomial approximations of the bias function previously developed for a fallback analysis plan. The magnitude of bias reduction and precision of the proposed estimators are assessed via simulations. Applications to biomarker-stratified, randomized phase III trials in oncology are provided.
Moderate dietary flavonoid intake associated with lower prevalence of Parkinson’s disease: data from the NHANES 2007–2010 and 2017–2018
Creators: name: Gong, Shanshan
name: Fei, Yuchang
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: To investigate the relationship between dietary flavonoids and the prevalence of PD. We used data from the 2007–2010 and 2017–2018 National Health and Nutrition Examination Survey (NHANES). Dietary flavonoid intake was assessed through a two-day, 24-hour dietary recall method, and PD diagnosis was ascertained by the presence of ‘Anti-Parkinson agents’ among the reported prescription medications. Logistic regression, subgroup, and restricted cubic spline (RCS) models were employed to analyze the connection between dietary flavonoids and PD prevalence. Our study revealed a correlation between the consumption of dietary total flavonoids, flavan-3-ols, and flavonols, and PD risk. Subgroup analysis indicated a negative correlation of dietary flavan-3-ols and total flavonoids with PD risk only among non-obese participants. Furthermore, our analysis using RCS demonstrated a nonlinear association between dietary flavonoids, flavan-3-ols, flavonols, and PD prevalence. We found that the optimal intake of total flavonoids, flavan-3-ols and flavonols wase 403.65 mg/day,346 mg/day and 26.74 mg/day, respectively. Above these thresholds, the risk of developing PD is elevated. Our study highlights a significant association between moderate dietary intake of total flavonoids, flavan-3-ols, and flavonols, and a reduced risk of PD. Our work may provide new therapeutic ideas for the prevention and treatment of PD and provide dietary flavonoid intake recommendations for PD patients.
Beobachtungen im Weißjura δ 3 und δ 4 ann der Autobahn bei Wiesensteig (Schwäbische Alb, Württemberg)
Creators: name: Gwinner, Manfred P.
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1958

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 113, 1958
Tagging amongst friends: an exploration of social media exchange on mobile devices
Creators: name: Casey, SA
Publisher: name: University of Lincoln
Year: 2024
Subjects: I100 - Computer science
I140 - Human-computer interaction

description: Mobile social software tools have great potential in transforming the way users communicateon the move, by augmenting their everyday environment with pertinent information fromtheir online social networks. A fundamental aspect to the success of these tools is indeveloping an understanding of their emergent real-world use and also the aspirations ofusers; this thesis focuses on investigating one facet of this: the exchange of social media. Tofacilitate this investigation, three mobile social tools have been developed for use on locationawaresmartphone handsets. The first is an exploratory social game, 'Gophers' that utilisestask oriented gameplay, social agents and GSM cell positioning to create an engagingecosystem in which users create and exchange geotagged social media. Supplementing this isa pair of social awareness and tagging services that integrate with a user's existing onlinesocial network; the 'ItchyFeet' service uses GPS positioning to allow the user and their socialnetwork peers to collaboratively build a landscape of socially important geotagged locations,which are used as indicators of a user's context on their Facebook profile; likewise'MobiClouds' revisits this concept by exploring the novel concept of Bluetooth 'peopletagging' to facilitate the creation of tags that are more indicative of users' social surroundings.The thesis reports on findings from formal trials of these technologies, using groups ofvolunteer social network users based around the city of Lincoln, UK, where the incorporationof daily diaries, interviews and automated logging precisely monitored application use.Through analysis of trial data, a guide for designers of future mobile social tools has beendevised and the factors that typically influence users when creating tags are identified. Thethesis makes a number of further contributions to the area. Firstly, it identifies the naturaldesire of users to update their status whilst mobile; a practice recently popularised bycommercial 'check in' services. It also explores the overarching narratives that developed overtime, which formed an integral part of the tagging process and augmented social media with ahigher level meaning. Finally, it reveals how social media is affected by the tag positioningmethod selected and also by personal circumstances, such as the proximity of social peers.
Support Material: Unsupervised Interpretable Representation Learningfor Singing Voice Separation
Creators: name: Mimilakis, Stylianos Ioannis
name: Drossos, Konstantinos
name: Schuller, Gerald
Publisher: name: Zenodo
Year: 2020
Subjects: Unsupervised Learning
Representation Learning
Differential Digital Signal Processing
Music Signal Processing

description: Support material for the manuscript entitled: "Unsupervised Interpretable Representation Learning for Singing Voice Separation". It contains binary files of the optimized and best performing models described in the corresponding manuscript.

 The attached file is to be used alongside the provided source code: https://github.com/Js-Mim/rl_singing_voice . We have provided an updated version of the results including additional insights.
title: 01_2460
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Ein Jubiläumsjahr der Juraforschung
Creators: name: Hölder, Helmut
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1958

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 113, 1958
Tagging amongst friends: an exploration of social media exchange on mobile devices
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: I100 - Computer science
I140 - Human-computer interaction

description: Mobile social software tools have great potential in transforming the way users communicateon the move, by augmenting their everyday environment with pertinent information fromtheir online social networks. A fundamental aspect to the success of these tools is indeveloping an understanding of their emergent real-world use and also the aspirations ofusers; this thesis focuses on investigating one facet of this: the exchange of social media. Tofacilitate this investigation, three mobile social tools have been developed for use on locationawaresmartphone handsets. The first is an exploratory social game, 'Gophers' that utilisestask oriented gameplay, social agents and GSM cell positioning to create an engagingecosystem in which users create and exchange geotagged social media. Supplementing this isa pair of social awareness and tagging services that integrate with a user's existing onlinesocial network; the 'ItchyFeet' service uses GPS positioning to allow the user and their socialnetwork peers to collaboratively build a landscape of socially important geotagged locations,which are used as indicators of a user's context on their Facebook profile; likewise'MobiClouds' revisits this concept by exploring the novel concept of Bluetooth 'peopletagging' to facilitate the creation of tags that are more indicative of users' social surroundings.The thesis reports on findings from formal trials of these technologies, using groups ofvolunteer social network users based around the city of Lincoln, UK, where the incorporationof daily diaries, interviews and automated logging precisely monitored application use.Through analysis of trial data, a guide for designers of future mobile social tools has beendevised and the factors that typically influence users when creating tags are identified. Thethesis makes a number of further contributions to the area. Firstly, it identifies the naturaldesire of users to update their status whilst mobile; a practice recently popularised bycommercial 'check in' services. It also explores the overarching narratives that developed overtime, which formed an integral part of the tagging process and augmented social media with ahigher level meaning. Finally, it reveals how social media is affected by the tag positioningmethod selected and also by personal circumstances, such as the proximity of social peers.
Ein Pseudosuchier aus dem Buntsandstein des Schwarzwalds
Creators: name: Huene, Friedrich von
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1958

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 113, 1958
Historic wrought iron minor architectural details in Lincolnshire: their development and conservation
Creators: name: Brown, David
Publisher: name: University of Lincoln
Year: 2024
Subjects: K100 - Architecture
K250 - Conservation of buildings
V360 - History of architecture

description: This research examines the hypothesis that more historic wrought iron minor architectural details (for example hinges, latches and brackets) survive than is often realised. It proves that they are often some of the oldest material in a building, having specific characteristics which are the result of their working and which influence design. Consequently, special consideration needs to be given to their conservation. They also demonstrate the skills of many unknown artisans who deserve greater recognition and appreciation for their roles in the country’s architectural and social history.The work is divided into three parts. The first part examines the development of the blacksmith’s craft, referring specifically to minor architectural details, the materials from which they were made, design development and the individuals involved in the craft. The second is a survey of a representative sample of extant historic ironwork details in Lincolnshire, examining their age, type and style, with an overview of their condition. The third is an evaluation of past and present methods of conservation of this material. The appendices show illustrations of some of the items discussed, and a gazetteer of historic ironwork identified in the survey.The original funding for this study was specifically for research in a field concerned with historic crafts or materials, with particular reference to Lincolnshire. It therefore concentrates on extant examples of wrought ironwork in the county from c1200 AD to c1860 AD, principally the work of individual craftsmen prior to their increased absorption into mass production industries. The significant role played by Cistercian monks and lay brothers of Lincolnshire monasteries in the development of the craft is considered, and some of the few records of Lincolnshire smiths which survive in local archives are examined, producing a greater insight into their involvement in this work than has been published previously.
Verbreitung, Gliederung und Alter der Lösse und Lehme auf den Fildern bei Stuttgart
Creators: name: Zürl, Kurt
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1958

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 113, 1958
Securing the future of African Innovation, Indigenous Knowledge and Cultural Heritage.
Creators: name: Owango, Joy
Publisher: name: My University
Year: 2024

description: Securing the future of African Innovation, Indigenous Knowledge and Cultural Heritage. - AfricArXiv Open Science Webinar Series 2024. Watch the recording here: https://africarxiv.pubpub.org/pub/ti9z956o/
description: Securing the future of African Innovation, Indigenous Knowledge and Cultural Heritage. - AfricArXiv Open Science Webinar Series 2024. Watch the recording here: https://africarxiv.pubpub.org/pub/ti9z956o/
Historic wrought iron minor architectural details in Lincolnshire: their development and conservation
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2024
Subjects: K100 - Architecture
K250 - Conservation of buildings
V360 - History of architecture

description: This research examines the hypothesis that more historic wrought iron minor architectural details (for example hinges, latches and brackets) survive than is often realised. It proves that they are often some of the oldest material in a building, having specific characteristics which are the result of their working and which influence design. Consequently, special consideration needs to be given to their conservation. They also demonstrate the skills of many unknown artisans who deserve greater recognition and appreciation for their roles in the country’s architectural and social history.The work is divided into three parts. The first part examines the development of the blacksmith’s craft, referring specifically to minor architectural details, the materials from which they were made, design development and the individuals involved in the craft. The second is a survey of a representative sample of extant historic ironwork details in Lincolnshire, examining their age, type and style, with an overview of their condition. The third is an evaluation of past and present methods of conservation of this material. The appendices show illustrations of some of the items discussed, and a gazetteer of historic ironwork identified in the survey.The original funding for this study was specifically for research in a field concerned with historic crafts or materials, with particular reference to Lincolnshire. It therefore concentrates on extant examples of wrought ironwork in the county from c1200 AD to c1860 AD, principally the work of individual craftsmen prior to their increased absorption into mass production industries. The significant role played by Cistercian monks and lay brothers of Lincolnshire monasteries in the development of the craft is considered, and some of the few records of Lincolnshire smiths which survive in local archives are examined, producing a greater insight into their involvement in this work than has been published previously.
Developing and sustaining teachers' professional learning: a case study of collaborative professional development
Creators: name: King, Fiona
Publisher: name: University of Lincoln
Year: 2024
Subjects: N224 - Management & organisation of education
X300 - Academic studies in education
X370 - Academic studies in education (across phases)

description: Despite economic difficulties, the emphasis on and investment in teacherprofessional development (PD) across the world continues, as countriesstrive to improve educational standards to compete in a globalisedknowledge economy. However, researchers have little evidence of its impacton teachers’ professional practice. While it is acknowledged that PD needs tobe assessed and evaluated, there is little guidance as to how this might beachieved. Much focus is on short-term impact, with longer-term impact oftenignored despite sustainability of practices being highlighted as critical forschool improvement.This study set out to explore the impact of a collaborative PD initiative onteachers’ professional practice in five urban disadvantaged primary schoolsin the Republic of Ireland. A qualitative approach was used to explore shorttermand longer-term impact, along with factors that helped or hindered thedevelopment and sustainability of the PD practice. The literature reviewrevealed gaps in existing frameworks for evaluation, resulting in thedevelopment of a ‘Professional Development Impact Evaluation Framework’which is presented in the thesis. It demonstrates how the framework wasboth developed from extant literature and critiqued through application, anddiscusses its potential for evaluating the impact of a range of PD activitiesand answering the call for accountability in these straitened times.Findings revealed a PD legacy that resulted not only in practices beingsustained, but demonstrating a PD multiplier, where the impact of thecollaborative PD initiative extended beyond the initiative itself to includemany changes, even at a cultural level. Given the significance of the PDmultiplier, this study suggests that PD facilitators support such culturalchanges on a larger scale in schools. A significant feature of change is theteacher as a change-agent, and this study proposes a number of typologiesof teacher engagement which may have some implications for teacher PD.Impacting on these typologies were three key elements that contributed toiiteachers’ professional learning and which reflect a developing notion ofagentic teacher professionalism: bottom-up approaches with top-downsupport; autonomy and professional trust; and collaborative practices andcollective responsibility.
Zur Ausbreitung der Fichte im Nordschwarzwald
Creators: name: Feucht, Otto
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1958

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 113, 1958
Point-of-care 3D printing at the Royal Brisbane & Women's Hospital
Creators: name: Crowe, Scott
name: Poroa, Tania
name: Wilks, Rachael
name: Kairn, Tanya
Publisher: name: Zenodo
Year: 2024
Subjects: 3D printing
radiotherapy

description: Poster describing point-of-care 3D printing of radiotherapy devices at the Royal Brisbane & Women's Hospital.
Developing and sustaining teachers' professional learning: a case study of collaborative professional development
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: N224 - Management & organisation of education
X300 - Academic studies in education
X370 - Academic studies in education (across phases)

description: Despite economic difficulties, the emphasis on and investment in teacherprofessional development (PD) across the world continues, as countriesstrive to improve educational standards to compete in a globalisedknowledge economy. However, researchers have little evidence of its impacton teachers’ professional practice. While it is acknowledged that PD needs tobe assessed and evaluated, there is little guidance as to how this might beachieved. Much focus is on short-term impact, with longer-term impact oftenignored despite sustainability of practices being highlighted as critical forschool improvement.This study set out to explore the impact of a collaborative PD initiative onteachers’ professional practice in five urban disadvantaged primary schoolsin the Republic of Ireland. A qualitative approach was used to explore shorttermand longer-term impact, along with factors that helped or hindered thedevelopment and sustainability of the PD practice. The literature reviewrevealed gaps in existing frameworks for evaluation, resulting in thedevelopment of a ‘Professional Development Impact Evaluation Framework’which is presented in the thesis. It demonstrates how the framework wasboth developed from extant literature and critiqued through application, anddiscusses its potential for evaluating the impact of a range of PD activitiesand answering the call for accountability in these straitened times.Findings revealed a PD legacy that resulted not only in practices beingsustained, but demonstrating a PD multiplier, where the impact of thecollaborative PD initiative extended beyond the initiative itself to includemany changes, even at a cultural level. Given the significance of the PDmultiplier, this study suggests that PD facilitators support such culturalchanges on a larger scale in schools. A significant feature of change is theteacher as a change-agent, and this study proposes a number of typologiesof teacher engagement which may have some implications for teacher PD.Impacting on these typologies were three key elements that contributed toiiteachers’ professional learning and which reflect a developing notion ofagentic teacher professionalism: bottom-up approaches with top-downsupport; autonomy and professional trust; and collaborative practices andcollective responsibility.
Die Legforche (Bergkiefer) im Nordschwarzwald
Creators: name: Feucht, Otto
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1958

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 113, 1958
Education policy and social justice: the experience of South African school principals
Creators: name: Turnbull, Margaret
Publisher: name: University of Lincoln
Year: 2024
Subjects: X300 - Academic studies in education

description: The purpose of this research is to gain insight into how school principals make sense of and promote social justice in their schools in South Africa. Underpinned by the ontological view that knowledge of the world comes from many perspectives, and set within the interpretive, constructionist paradigms, this qualitative study explores seven principals’ attempts to promote social justice. The data was gathered using semi-structured interviews with principals and staff members from schools in both the public and independent sectors. The findings reveal the principals’ interpretation of social justice. They also identify those frameworks of leadership which when applied by principals,appear to support social justice better. The thesis argues that principals’ efforts to promote social justice are constrained by government policies and further compounded by the lack of capacity, in terms of individuals’ ability and understanding, at a National or Provincial level. It is also argued that the community within which the school is positioned significantly influences the principals’ attempts to promote social justice. It was also evident that the principals have interpreted and reinterpreted social and cultural justice in light of the context within which their school is positioned. The conclusion is that despite principals’ attempts to promote social justice, both the school context and external political and economic factors significantly constrain their success. Hence education in South Africa continues to struggle to deliver social justice to the majority of learners. This research contributes to the limited literature on leadership in So uth Africa and provides a voice for school leaders to identify the reality they face, rather than expressing the rhetoric of the government.
Education policy and social justice: the experience of South African school principals
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: X300 - Academic studies in education

description: The purpose of this research is to gain insight into how school principals make sense of and promote social justice in their schools in South Africa. Underpinned by the ontological view that knowledge of the world comes from many perspectives, and set within the interpretive, constructionist paradigms, this qualitative study explores seven principals’ attempts to promote social justice. The data was gathered using semi-structured interviews with principals and staff members from schools in both the public and independent sectors. The findings reveal the principals’ interpretation of social justice. They also identify those frameworks of leadership which when applied by principals,appear to support social justice better. The thesis argues that principals’ efforts to promote social justice are constrained by government policies and further compounded by the lack of capacity, in terms of individuals’ ability and understanding, at a National or Provincial level. It is also argued that the community within which the school is positioned significantly influences the principals’ attempts to promote social justice. It was also evident that the principals have interpreted and reinterpreted social and cultural justice in light of the context within which their school is positioned. The conclusion is that despite principals’ attempts to promote social justice, both the school context and external political and economic factors significantly constrain their success. Hence education in South Africa continues to struggle to deliver social justice to the majority of learners. This research contributes to the limited literature on leadership in So uth Africa and provides a voice for school leaders to identify the reality they face, rather than expressing the rhetoric of the government.
Becoming a primary school principal in Ireland: deputy-principalship as preparation
Creators: name: Grant, Derrick
Publisher: name: University of Lincoln
Year: 2024
Subjects: X300 - Academic studies in education

description: This thesis investigated influences on primary school deputy-principals’ motivations to apply for principalship in the early twenty-first century in the Irish Republic. This required the exploration of both principals’ and deputy-principals’ roles in management and leadership to discover how better to prepare deputies to continue to the principalship. The research approach sat firmly within the qualitative paradigm, using semi-structured interviews with twelve primary deputy-principals exploring their construction of deputyship and principalship from their professional socialisation experiences. Findings revealed the complex relationship which exists between both roles and the extent to which the pervading school culture determines how much meaningful leadership opportunity is distributed beyond the principal. A major outcome of the study is a constructed knowledge of the nature and culture of Irish primary deputyship. Three new typologies of deputy-principalship provide a new perspective on the deputyship role, concluding that the gap in experiences and knowledge between deputyship and principalship is so great that energy should flow into the formation of formal, planned and structured preparation for a deputyship transition into principalship.
Die Verbreitung der Mistel im mittleren Neckarland
Creators: name: Kreh, Wilhelm
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1958

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 113, 1958
Becoming a primary school principal in Ireland: deputy-principalship as preparation
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: X300 - Academic studies in education

description: This thesis investigated influences on primary school deputy-principals’ motivations to apply for principalship in the early twenty-first century in the Irish Republic. This required the exploration of both principals’ and deputy-principals’ roles in management and leadership to discover how better to prepare deputies to continue to the principalship. The research approach sat firmly within the qualitative paradigm, using semi-structured interviews with twelve primary deputy-principals exploring their construction of deputyship and principalship from their professional socialisation experiences. Findings revealed the complex relationship which exists between both roles and the extent to which the pervading school culture determines how much meaningful leadership opportunity is distributed beyond the principal. A major outcome of the study is a constructed knowledge of the nature and culture of Irish primary deputyship. Three new typologies of deputy-principalship provide a new perspective on the deputyship role, concluding that the gap in experiences and knowledge between deputyship and principalship is so great that energy should flow into the formation of formal, planned and structured preparation for a deputyship transition into principalship.
Correcting Estimation Bias in Randomized Clinical Trials with a Test of Treatment-by-Biomarker Interaction
Creators: name: Kiichiro Toyoizumi
name: Matsui, Shigeyuki
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 60506 Virology

description: The key elements in recent drug development aiming toward personalized medicine involve the development of baseline predictive biomarkers to predict the responsiveness to new treatments. When biological evidence to support the biomarker hypothesis is not strong, it is particularly important to evaluate the clinical validity of a predictive biomarker based on data from clinical trials. All-comers randomized clinical trials stratified with biomarker measurements can provide the opportunity to evaluate the predictive value of the biomarker, and a test of treatment-by-biomarker interaction is applied for this purpose. If the interaction is significant, it is natural to proceed to a subgroup analysis that evaluates treatment efficacy within biomarker-based subgroups. However, estimation bias can arise when using the standard estimation method without regard to the significant interaction because of the correlation between the interaction test and subgroup analysis. In this paper, after evaluating the bias function for the standard estimators, we provide bias-corrected point and interval estimation methods, including polynomial approximations of the bias function previously developed for a fallback analysis plan. The magnitude of bias reduction and precision of the proposed estimators are assessed via simulations. Applications to biomarker-stratified, randomized phase III trials in oncology are provided.
Über die Verbreitung der rezenten Viviparus-Arten, besonders im südwestdeutschen Raum
Creators: name: Herold, Harry
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1958

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 113, 1958