cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Consolidation radiotherapy for advanced-stage aggressive B-cell non-Hodgkin lymphoma
title: a systematic review and meta-analysis
titleType: AlternativeTitle
Creators: name: Yap, Ernie
name: Law, Zhe Kang
name: Aslan Abdullah, Nik Muhd
name: Abdul Wahid, S. Fadilah
Publisher: name: Technische Universität Dortmund
Year: 2017
Subjects: subject: Non-Hodgkin lymphoma
subject: Radiotherapy
subject: Aggressive B cell NHL
subject: Meta-analysis
subject: 610

description: Patients with advanced aggressive B-cell non-Hodgkin lymphomas (NHL) are usually treated with rituximab in combination with chemotherapy. However, disease relapse rates are high. Radiotherapy (RT) has been shown to be efficacious in treating early-stage NHL but its role in advanced stage diseases is unclear. We performed a systematic review of randomized controlled trials (RCTs) comparing chemotherapy with RT to chemotherapy alone in patients with newly diagnosed advanced aggressive NHL. We searched online databases and pooled similar outcome estimates. For time-to-event outcomes, we estimated hazard ratios (HR) for overall survival (OS) and event-free survival (EFS) using the fixed-effect model. Two RCTs involving 254 patients met inclusion criteria. The trials were single-centre RCTs with follow-up period of five and ten years. Both trials were conducted in the pre-rituximab era. Patients treated with consolidation RT had better OS (HR for mortality 0.61; 95 % CI 0.38 to 0.97) and EFS (HR for mortality 0.67; 95 % CI 0.46 to 0.98) compared to those who received no RT. There was an apparent benefit of RT on local control (OR 0.09; 95 % CI 0.04 to 0.20); although this was estimated as a dichotomous rather than time-to-event outcome. Limited evidence shows benefits of consolidation RT in advanced aggressive NHL. However, we were not able to estimate the effect size with confidence due to small number of trials and sample size. We cannot recommend routine consolidation RT in advanced aggressive NHL. More RCTs with the inclusion of rituximab and PET-CT monitoring are needed.
description: EXCLI Journal;Vol. 16 2017
Stokes flows in three-dimensional fluids with odd and parity-violating viscosities
Creators: name: Khain, Tali
name: Scheibner, Colin
name: Fruchart, Michel
name: Vitelli, Vincenzo
Publisher: name: arXiv
Year: 2020
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: The Stokes equation describes the motion of fluids when inertial forces are negligible compared to viscous forces. In this article, we explore the consequence of parity-violating and non-dissipative (i.e. odd) viscosities on Stokes flows in three dimensions. Parity-violating viscosities are coefficients of the viscosity tensor that are not invariant under mirror reflections of space, while odd viscosities are those which do not contribute to dissipation of mechanical energy. These viscosities can occur in systems ranging from synthetic and biological active fluids to magnetised and rotating fluids. We first systematically enumerate all possible parity-violating viscosities compatible with cylindrical symmetry, highlighting their connection to potential microscopic realizations. Then, using a combination of analytical and numerical methods, we analyze the effects of parity-violating viscosities on the Stokeslet solution, on the flow past a sphere or a bubble, and on many-particle sedimentation. In all the cases we analyze, parity-violating viscosities give rise to an azimuthal flow even when the driving force is parallel to the axis of cylindrical symmetry. For a few sedimenting particles, the azimuthal flow bends the trajectories compared to a traditional Stokes flow. For a cloud of particles, the azimuthal flow impedes the transformation of the spherical cloud into a torus and the subsequent breakup into smaller parts that would otherwise occur. The presence of azimuthal flows in cylindrically symmetric systems (sphere, bubble, cloud of particles) can serve as a probe for parity-violating viscosities in experimental systems.
description: 39 pages, 12 figures. Supplementary movies at https://home.uchicago.edu/~vitelli/videos.html
An in silico approach in predicting the possible mechanism involving restoration of wild-type p53 functions by small molecular weight compounds in tumor cells expressing R273H mutant p53
Creators: name: Malami, Ibrahim
name: Muhammad, Aliyu
name: Etti, Imaobong C.
name: Waziri, Peter M.
name: Alhassan, Alhassan M.
Publisher: name: Technische Universität Dortmund
Year: 2017
Subjects: subject: molecular docking simulation
subject: R273H mutant p53
subject: flavokawain B
subject: alpinetin
subject: curcumin
subject: DNA-binding domain
subject: 610

description: R273H mutant p53 is a DNA-contact mutant that renders p53 dysfunctional due to a single substitution of Arg273 for His273. Rescuing R273 mutant p53 implies that a competent molecule would have to bind to the site of DNA-contact hot spots to complement the loss of contact with the DNA-binding domain. Here, curcumin, flavokawain B, and alpinetin were docked against the crystal structure of R273H mutant p53 in silico. Consequently, all the compounds bind to the cavity of R273H mutant p53 with a dissociation constant estimated to have 36.57, 70.77, and 75.11 μM for curcumin, flavokawain B, and alpinetin, respectively. Subsequently, each molecule was able to bind to the R273H mutant p53 by interacting with the DNA-contact hot spot Arg248 and mutant R273H, thereby compensating for the loss of direct contact with the DNA-binding domain. Furthermore, all the molecules were able to induce a direct contact with the consensus site of the DNA binding domain, thus maintaining DNA-contact residues with the DNA. The present findings offer reliminary indirect supporting evidence that small molecular weight compounds may certainly rescue DNA-contact mutant p53, which may lay a foundation for designing a competent and effective molecule capable of rescuing mutant p53 in tumor cells expressing R273H mutant p53.
description: EXCLI Journal;Vol. 16 2017
Field theoretical approach for signal detection in nearly continuous positive spectra II: Tensorial data
Creators: name: Lahoche, Vincent
name: Ouerfelli, Mohamed
name: Samary, Dine Ousmane
name: Tamaazousti, Mohamed
Publisher: name: arXiv
Year: 2020
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: The tensorial principal component analysis is a generalization of ordinary principal component analysis, focusing on data which are suitably described by tensors rather than matrices. This paper aims at giving the nonperturbative renormalization group formalism based on a slight generalization of the covariance matrix, to investigate signal detection for the difficult issue of nearly continuous spectra. Renormalization group allows constructing effective description keeping only relevant features in the low ``energy'' (i.e. large eigenvalues) limit and thus provides universal descriptions allowing to associate the presence of the signal with objectives and computable quantities. Among them, in this paper, we focus on the vacuum expectation value. We exhibit experimental evidence in favor of a connection between symmetry breaking and the existence of an intrinsic detection threshold, in agreement with our conclusions for matrices, providing a new step in the direction of a universal statement.
description: 12 pages, 6 figures
Detection of aflatoxin-producing fungi isolated from Nile Tilapia and fish feed
Creators: name: Mohamed, Hams M.A.
name: Emeish, Walaa F.A.
name: Braeuning, Albert
name: Hammad, Seddik
Publisher: name: Technische Universität Dortmund
Year: 2017
Subjects: subject: Oreochromus niloticus
subject: A. flavus
subject: Aflatoxins
subject: Clove oil
subject: 610

description: Contamination of fish by fungi and their mycotoxins poses major health concerns to human and animals. Therefore, our study was aimed to investigate Aspergillus flavus (A. flavus) infections and the levels of aflatoxins in Nile tilapia, Oreochromis niloticus (O. niloticus), and fish feed. Samples from O. niloticus and fish feed (n=25 for each) were randomly collected from private fish farms at Qena province, Egypt, during the winter season. Different Aspergillus spp. were detected in 60 % and 64 % of O. niloticus and fish feed, respectively. HPLC-based analysis revealed aflatoxin-producing activity in 75 % and 83 % of A. flavus isolates from fish and fish feed, respectively. While 96 % of O. niloticus muscles and fish feed samples were contaminated with aflatoxins, the detected levels were below the permissible limits, i.e. 20 μg/kg. Moreover, experimental infection with toxicogenic A. flavus isolates was conducted to evaluate their pathogenicity in O. niloticus. Expectedly, experimental infections of O. niloticus with A. flavus were associated with several clinical symptoms reported in naturally infected fish, e.g. yellow coloration with skin ulceration, hemorrhagic ulcerative patches on gills and skin, corneal opacity, fin rot and abdominal distention. Furthermore, aflatoxicogenic A. flavus isolates from fish were sensitive to herbal clove oil.Even though the measured levels of aflatoxin were below permissible limits, effort should be placed on furtherreduction of exposure to genotoxic and carcinogenic mycotoxins.
description: EXCLI Journal;Vol. 16 2017
High intermodulation gain in a micromechanical Duffing resonator
Creators: name: Almog, R.
name: Zaitsev, S.
name: Shtempluck, O.
name: Buks, E.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: In this work we use a micromechanical resonator to experimentally study small signal amplification near the onset of Duffing bistability. The device consists of a PdAu beam serving as a micromechanical resonator excited by an adjacent gate electrode. A large pump signal drives the resonator near the onset of bistability, enabling amplification of small signals in a narrow bandwidth. To first order, the amplification is inversely proportional to the frequency difference between the pump and signal. We estimate the gain to be about 15dB for our device.
DYNASTIES AND DESTINY: ON THE ROLES OF ALTRUISM AND IMPATIENCE IN THE EVOLUTION OF CONSUMPTION AND BEQUESTS
Creators: name: Stark, Oded
name: Falk, Ita
name: Stark, Oded
name: Falk, Ita
Publisher: name: Unknown
Year: 2001
Subjects: Institutional and Behavioral Economics

description: We study the joint role of altruism and impatience, and the impact of evolution in the formation of long-term time preferences and in the determination of optimal consumption and optimal bequests. We show how the consumption paths of dynasties relate to altruism and to impatience, and we reason that long-lived dynasties will be characterized by a higher degree of altruism and a lower degree of impatience than short-lived dynasties.
Ultranarrow spectral line of the radiation in double qubit-cavity ultrastrong coupling system
Creators: name: Zhao, Teng
name: Wu, Shao-ping
name: Yang, Guo-qing
name: Huang, Guang-ming
name: Li, Gao-Xiang
Publisher: name: arXiv
Year: 2020
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The ultrastrongly coupling (USC) system has very important research significance in quantum simulation and quantum computing. In this paper, the ultranarrow spectrum of a circuit QED system with two qubits ultrastrongly coupled to a single-mode cavity is studied. In the regime of USC, the JC model breaks down and the counter-rotating terms in the quantum Rabi Hamiltonian leads to the level anti-crossing in the energy spectrum. Choosing a single-photon driving field at the point of avoided-level crossing, we can get an equivalent four-level dressed state model, in which the dissipation of the two intermediate states is only related to the qubits decay. Due to the electron shelving of these two metastable states, a narrow peak appears in the cavity emission spectrum. Furthermore, we find that the physical origin for the spectral narrowing is the vacuum-induced quantum interference between two transition pathways. And this interference effect couples the slowly decaying incoherent components of the density matrix into the equations of the sidebands. This result provides a possibility for the study of quantum interference effect in the USC system.
THE ECONOMICS OF VALUE ENHANCED CROPS: AN ANALYSIS OF BENEFIT SHARING IN THE U.S.
Creators: name: Jefferson, Kenrett Y.
name: Traxler, Greg
name: Jefferson, Kenrett Y.
name: Traxler, Greg
Publisher: name: Unknown
Year: 2002
Subjects: subject: Crop Production/Industries
subject: value enhanced crops
subject: genetically modified organisms
subject: monopsony markets

description: The introduction of a second wave of product quality GMOs has the potential to provide new momentum to the agricultural biotechnology industry. The challenge facing the industry is to generate innovations that will allow them to offer a large adoption incentive while capturing sufficient revenues to support R&D investment.
Length-dependent resistance model for a single-wall Carbon nanotube
Creators: name: Arulsamy, Andrew Das
name: Fronzi, Marco
Publisher: name: arXiv
Year: 2005
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The non-linear length-dependent resistance, $\mathcal{R}(l)$ observed in single-wall Carbon nanotubes (SNTs) is explained through the recently proposed ionization energy ($E_I$) based Fermi-Dirac statistics ($i$FDS). The length here corresponds to the Carbon atoms number ($\mathcal{N}$) along the SNT. It is also shown that $\mathcal{R}_y(l_y)$ $
description: Published
Association between single nucleotide polymorphisms in the PI3K/AKT/mTOR pathway and bladder cancer risk in a sample of Iranian population
Creators: name: Bizhani, Fatemeh
name: Hashemi, Mohammad
name: Danesh, Hiva
name: Nouralizadeh, Akbar
name: Narouie, Behzad
name: Bahari, Gholamreza
name: Ghavami, Saeid
Publisher: name: Technische Universität Dortmund
Year: 2018
Subjects: subject: PIK3CA
subject: AKT1
subject: mTOR
subject: Polymorphism
subject: Bladder cancer
subject: 610

description: In the past few years several investigations have focused on the role of PI3K/AKT/mTOR pathway and its deregulations in different cancers. This study aimed to examine genetic polymorphisms of this pathway in bladder cancer (BC). In this case-control study, 235 patients with pathologically confirmed bladder cancer and 254 control subjects were examined. PIK3CA, AKT1 and mTOR variants were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The findings proposed that the PIK3CA rs6443624 SNP significantly decreased the risk of BC (OR=0.44, 95 % CI=0.30-0.65, p<0.0001 CA vs CC; OR=0.35, 95 % CI=0.16-0.78, p=0.0107, AA vs CC; OR=0.60, 95 % CI=0.46-0.79, p=0.0002, A vs T). The AKT1 rs2498801 variant is associated with a decreased risk of BC (OR=0.57, 95 % CI=0.39-0.82, p=0.003, AG vs AA; OR=0.74, 95 % CI=0.56-0.97, p=0.032, G vs A) while, AKT1 rs1130233 polymorphism considerably increased the risk of BC (OR=3.70, 95 % CI=2.52-5.43, p<0.0001, GA vs GG; OR=5.81, 95 % CI=1.53-21.97, p=0.010, AA vs GG; OR=2.71, 95 % CI=1.98-3.70, p<0.0001, A vs G). Additionally, mTOR rs2295080 variant notably increased the risk of BC (OR=2.25, 95 % CI=1.50-3.38, p<0.0001, GT vs GG; OR=4.75, 95 % CI=2.80-8.06, p<0.0001, TT vs GG; OR=3.10, 95 % CI=2.34-4.10, p<0.0001, T vs G). None of the other examined polymorphisms (AKT1 rs1130214, AKT1 rs3730358, mTOR rs1883965) revealed significant association with BC. In conclusion, our findings suggest that PIK3CA rs6443624, AKT1 rs2498801, AKT1 rs1130233, as well mTOR rs2295080 polymorphism may be related to bladder cancer development in a sample of Iranian population. Validation of our findings in larger sample sizes of different ethnicities would provide evidence on the role of variants of PI3K/AKT/mTOR pathway in developing BC.
description: EXCLI Journal;Vol. 17 2018
Towards a Perfect QCD Gravity Dual
Creators: name: Evans, Nick
name: Shock, Jonathan P.
name: Waterson, Tom
Publisher: name: arXiv
Year: 2005
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Many examples of gravitational duals exist of theories that are highly supersymmetric and conformal in the UV yet have the same massless states as {\cal N}=2,1,0 QCD. We discuss such theories with an explicit UV cutoff and propose that, by tuning higher dimension operators at the cutoff by hand, the effects of the extra matter states in the UV may be removed from the IR physics. We explicitly work in the AdS-Schwartzschild description of QCD_4 and tune the operator TrF^4 by relaxing the near horizon limit to reproduce the lattice 0^{++} glueball mass results. We find that to reproduce the lattice data, the IR and UV cutoffs lie close to each other and there is essentially no AdS-like period between them. The improved geometry gives a better match to the lattice data for 0^{-+} glueball masses.
description: 11 pages, 2 figures; typos corrected, references added
title: Highly potent antioxidant Olea europaea L. leaf extract affects carotid and renal haemodynamics in experimental hypertension
title: the role of oleuropein
titleType: AlternativeTitle
Creators: name: Ivanov, Milan
name: Vajic, Una-Jovana
name: Mihailovic-Stanojevic, Nevena
name: Miloradovic, Zoran
name: Jovovic, Djurdjica
name: Grujic-Milanovic, Jelica
name: Karanovic, Danijela
name: Dekanski, Dragana
Publisher: name: Technische Universität Dortmund
Year: 2018
Subjects: subject: Olive leaf extract
subject: Oleuropein
subject: Vascular resistance
subject: Blood pressure
subject: Oxidative stress
subject: 610

description: Haemodynamic alterations in carotid and renal arteries are associated with the severity of target organ damage in patients with hypertension. Dietary habits, such as the Mediterranean diet, regulate blood pressure and oxidative stress, thus reduce the mortality rate due to cardiovascular diseases. In this study, our aim was to evaluate the reducing activity, antioxidant capacity and metal chelating ability of standardized Olea europaea L. leaf extract (OLE), and to test its (5, 25, 50 mg/kg) acute in vivo effects, as well as oleuropein’s (OP, 10 mg/kg) on oxidative stress, carotid, renal and systemic haemodynamic parameters (blood pressure, heart rate, cardiac output, peripheral resistance) in spontaneously hypertensive rats (SHR). OLE has a higher antioxidative capacity than BHT, higher reducing ability than vitamin C, and 23 times lower capacity for metal ion chelation than EDTA. All three doses of OLE, and OP, improved oxidative stress in SHR. OLE5 improved carotid and renal haemodynamics, without significant effects on systemic haemodynamics. Two different mechanisms of antihypertensive responses to OLE were observed, OLE25 was most effective in reducing cardiovascular risks by improving systemic and regional (carotid and renal) haemodynamics, peripheral and regional vascular resistance. OLE50 causes the improvement of blood pressure and cardiac performances, but tends to retain elevated vascular resistance, therefore, reducing the inflow of blood into the brain and kidneys of the SHR. The OP did not alter systemic or regional haemodynamics, suggesting others constituents responsible for changes of cardiac function, as well as carotid and renal haemodynamics in response to OLE50.
description: EXCLI Journal;Vol. 17 2018
Assessment of weak-coupling approximations on a driven two-level system under dissipation
Creators: name: Teixeira, Wallace S.
name: Semião, Fernando L.
name: Tuorila, Jani
name: Möttönen, Mikko
Publisher: name: arXiv
Year: 2020
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The standard weak-coupling approximations associated to open quantum systems have been extensively used in the description of a two-level quantum system, qubit, subjected to relatively weak dissipation compared with the qubit frequency. However, recent progress in the experimental implementations of controlled quantum systems with increased levels of on-demand engineered dissipation has motivated precision studies in parameter regimes that question the validity of the approximations, especially in the presence of time-dependent drive fields. In this paper, we address the precision of weak-coupling approximations by studying a driven qubit through the numerically exact and non-perturbative method known as the stochastic Liouville-von Neumann equation with dissipation. By considering weak drive fields and a cold Ohmic environment with a high cutoff frequency, we use the Markovian Lindblad master equation as a point of comparison for the SLED method and study the influence of the bath-induced energy shift on the qubit dynamics. We also propose a metric that may be used in experiments to map the regime of validity of the Lindblad equation in predicting the steady state of the driven qubit. In addition, we study signatures of the well-known Mollow triplet and observe its meltdown owing to dissipation in an experimentally feasible parameter regime of circuit electrodynamics. Besides shedding light on the practical limitations of the Lindblad equation, we expect our results to inspire future experimental research on engineered open quantum systems, the accurate modeling of which may benefit from non-perturbative methods.
description: 32 pages, 5 figures, modified version published in New Journal of Physics
New perspectives on output feedback stabilization at an unobservable target
Creators: name: Brivadis, Lucas
name: Gauthier, Jean-Paul
name: Sacchelli, Ludovic
name: Serres, Ulysse
Publisher: name: arXiv
Year: 2020
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics

description: We address the problem of dynamic output feedback stabilization at an unobservable target point. The challenge lies in according the antagonistic nature of the objective and the properties of the system: the system tends to be less observable as it approaches the target. We illustrate two main ideas: well chosen perturbations of a state feedback law can yield new observability properties of the closed-loop system, and embedding systems into bilinear systems admitting observers with dissipative error systems allows to mitigate the observability issues. We apply them on a case of systems with linear dynamics and nonlinear observation map and make use of an ad hoc finite-dimensional embedding. More generally, we introduce a new strategy based on infinite-dimensional unitary embeddings. To do so, we extend the usual definition of dynamic output feedback stabilization in order to allow infinite-dimensional observers fed by the output. We show how this technique, based on representation theory, may be applied to achieve output feedback stabilization at an unobservable target.
title: Calcium pyrophosphate dihydrate deposition disease of the temporomandibular joint
Creators: name: McLeish, Robert
Publisher: name: EURORAD
Year: 2024
Subjects: subject: Head & neck imaging
subject: Head and neck
subject: Musculoskeletal joint
subject: CT
subject: Clinical Case

description: Clinical History: A 73-year-old female attended the OMFS department with a history of pain and swelling around the left TMJ region. Clinically, she had reduced mouth opening at 35mm, with normal rotation and lateral deviation of the joints bilaterally. No clicking or crepitus was present on auscultation with a normal occlusion.

description: 73 years, female
Calibrated Stochastic Dynamic Models for Resource Management
Creators: name: Howitt, Richard E.
name: Reynaud, Arnaud
name: Msangi, Siwa
name: Knapp, Keith C.
name: Howitt, Richard E.
name: Reynaud, Arnaud
name: Msangi, Siwa
name: Knapp, Keith C.
Publisher: name: Unknown
Year: 2002
Subjects: Resource /Energy Economics and Policy

description: In this paper we develop a positive calibrated approach to stochastic dynamic programming. Risk aversion, discount rate, and intertemporal substitution preferences of the decision-maker are calibrated by a procedure that minimizes the mean squared error from data on past decisions. We apply this framework to managing stochastic water supplies from Oroville Reservoir, located in Northern California. The calibrated positive SDP closely reproduces the historical storage and releases from the dam and shows sensitivity of optimal decisions to a decision-maker's risk aversion and intertemporal preferences. The calibrated model has average prediction errors that are substantially lower than those from the model with an expected net present value objective.
Protective effects of hydrogen sulfide on chronic kidney disease by reducing oxidative stress, inflammation and apoptosis
Creators: name: Askari, Hassan
name: Seifi, Behjat
name: Kadkhodaee, Mehri
name: Sanadgol, Nima
name: Elshiekh, Mohammed
name: Ranjbaran, Mina
name: Ahghari, Parisa
Publisher: name: Technische Universität Dortmund
Year: 2018
Subjects: subject: Chronic kidney disease
subject: Hydrogen sulfide
subject: Oxidative stress
subject: Apoptosis
subject: Inflammation
subject: Creatinine clearance
subject: Blood pressure
subject: 610

description: The current study aimed to examine the renoprotective effects of long-term treatment with sodium hydrosulfide (NaHS), a prominent hydrogen sulfide donor, in 5/6 nephrectomy animal model. Twenty-four rats were randomly divided into 3 groups including sham-operated group (Sham), 5/6-nephrectomized group (5/6 Nx), and NaHStreated group (5/6Nx+NaHS). NaHS (30 micromol/l) was added twice daily into the drinking water and renal failure was induced by 5/6 nephrectomy. Twelve weeks after surgical procedure, blood pressure, creatinine clearance (CCr), urine concentration of neutrophil gelatinase associated lipocalin (NGAL) and tissue concentration of malondialdehyde (MDA), superoxide dismutase (SOD), as well as renal morphological changes, apoptosis (cleaved caspase-3) and inflammation (p-NF-κB) were measured. Five-sixth nephrectomy induced severe renal damage as indicated by renal dysfunction, hypertension and significant histopathological injury which were associated with increased NGAL and MDA levels, oxidant/antioxidant imbalance, decreased SOD activity and CCr and also overexpression of p-NF-κB and cleaved caspase-3 proteins. Instead, NaHS treatment attenuated renal dysfunction through reduction of NGAL concentration, hypertension, CCr, oxidant/antioxidant imbalance, inflammation and apoptosis. These findings suggest that long term NaHS treatment can be useful in preventing the progression of CKD by improving oxidant/antioxidant balance and reducing inflammation and apoptosis in the kidney.
description: EXCLI Journal;Vol. 17 2018
Toward a universal model for spatially structured populations
Creators: name: Marrec, Loïc
name: Lamberti, Irene
name: Bitbol, Anne-Florence
Publisher: name: arXiv
Year: 2020
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: A key question in evolution is how likely a mutant is to take over. This depends on natural selection and on stochastic fluctuations. Population spatial structure can impact mutant fixation probabilities. We introduce a model for structured populations on graphs that generalizes previous ones by making migrations independent of birth and death. We demonstrate that by tuning migration asymmetry, the star graph transitions from amplifying to suppressing natural selection. The results from our model are universal in the sense that they do not hinge on a modeling choice of microscopic dynamics or update rules. Instead, they depend on migration asymmetry, which can be experimentally tuned and measured.
description: 30 pages, 12 figures
Mitochondrial DNA copy number instability in ERBB2-amplified breast cancer tumors
Creators: name: Ebrahimi, Elmira
name: Almasi-Hashiani, Amir
name: Ghaffari, Kimia
name: Shirkoohi, Reza
Publisher: name: Technische Universität Dortmund
Year: 2018
Subjects: subject: Breast cancer
subject: Epidermal Growth Factor Receptor
subject: Gene amplification
subject: Genomic instability
subject: Mitochondrial DNA
subject: 610

description: Increase in the copy number of ERBB2, a Tyrosine Kinase Receptor (TKR) leads to the overexpression of oncogene product and consequently uncontrolled cell proliferation which has been reported in different aggressive cancers with mitochondrial malfunctions. Although, amplification of ERBB2 has been reported in different studies; however, the association between changes in mitochondrial DNA content and the ERBB2 gene copy number is poorly understood. The relative mitochondrial DNA content of breast cancer tumor tissues of 70 patients who were referred to Imam Khomeini Hospital Complex was determined using quantitative Real-time PCR. Multiplex ligation-dependent probe amplification (MLPA) was conducted to evaluate the ERBB2 gene copy number variation and finally, two-sample Wilcoxon rank-sum (Mann-Whitney) test was used to investigate the possible association between mitochondrial DNA (mtDNA) content and the ERBB2 gene amplification. Seventeen out of 70 breast cancer tumor tissues were found with ERBB2 gene amplification. Comparison of the mitochondrial DNA content of the aforementioned samples with the rest of the cases showed a significant decrease in the mitochondrial DNA content of the ERBB2-amplified samples (P=0.01). Our data provided evidence that ERBB2 have the potential to have a regulatory role over mitochondrial activity by controlling the mtDNA content.
description: EXCLI Journal;Vol. 17 2018
Superconducting Circuits and Quantum Information
Creators: name: You, J. Q.
name: Nori, Franco
Publisher: name: arXiv
Year: 2006
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Superconducting circuits can behave like atoms making transitions between two levels. Such circuits can test quantum mechanics at macroscopic scales and be used to conduct atomic-physics experiments on a silicon chip.
description: 7 pages, 4 figures. See also: http://www.physicstoday.org/vol-58/iss-11/contents.html
[Brev til DKNVS]
Creators: name: Bugge, Frederik Moltke
name: Det Kongelige Norske Videnskabers Selskab (DKNVS)
Publisher: name: Unknown
Year: 1842

description: Vedr. Nicolai Lunds brev
description: Se j.nr.5. Polydoc nr. 1: 2476. Polydoc nr. 2: 1902.
Exact curvilinear diffusion coefficients in the repton model
Creators: name: Buhot, Arnaud
Publisher: name: arXiv
Year: 2005
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: The Rubinstein-Duke or repton model is one of the simplest lattice model of reptation for the diffusion of a polymer in a gel or a melt. Recently, a slightly modified model with hardcore interactions between the reptons has been introduced. The curvilinear diffusion coefficients of both models are exactly determined for all chain lengths. The case of periodic boundary conditions is also considered.
description: 6 pages and 5 figures, to be published in EPJE
SOYBEAN PRODUCTION COSTS: AN ANALYSIS OF THE UNITED STATES, BRAZIL, AND ARGENTINA
Creators: name: Huerta, Alexandria I.
name: Martin, Marshall A.
name: Huerta, Alexandria I.
name: Martin, Marshall A.
Publisher: name: Unknown
Year: 2002
Subjects: Crop Production/Industries

description: U.S. farmers' share of world soybean exports has declined, while Brazil and Argentina are gaining. There is much debate concerning the competitive advantage of U.S. versus Latin American soybean producers. A detailed analysis of soybean production costs under different systems and technologies in the United States, Argentina, and Brazil was conducted.
Recent updates on neuropharmacological effects of luteolin
Creators: name: Gupta, Gaurav
name: Tiwari, Juhi
name: Dahiya, Rajiv
name: Kumar Sharma, Rakesh
name: Mishra, Anurag
name: Dua, Kamal
Publisher: name: Technische Universität Dortmund
Year: 2018
Subjects: subject: 610

description: EXCLI Journal;Vol. 17 2018
PRICE TRANSMISSION AND ASYMMETRIC ADJUSTMENT IN THE SPANISH DAIRY SECTOR
Creators: name: Serra, Teresa
name: Goodwin, Barry K.
name: Serra, Teresa
name: Goodwin, Barry K.
Publisher: name: Unknown
Year: 2002
Subjects: Livestock Production/Industries

description: Asymmetric threshold error correction models are used to analyze price relationships and patterns of transmission among farm and retail markets for a variety of dairy products in Spain. Our empirical analysis is conducted using both weekly and monthly price data. Our results suggest that the transmission of shocks is largely unidirectional, running from the farm to retail levels. Formal tests confirm asymmetries, though our results suggest that the effects of these asymmetries are modest. Implications for the organizational structure of Spanish dairy markets are offered.
On Positive Recurrence of Constrained Diffusion Processes
Creators: name: Atar, Rami
name: Budhiraja, Amarjit
name: Dupuis, P.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: Primary 60J60; secondary 60J65, 60K25, 34D20

description: Let G \subset \R^k be a convex polyhedral cone with vertex at the origin given as the intersection of half spaces {G_i, i= 1, ..., N}, where n_i and d_i denote the inward normal and direction of constraint associated with G_i, respectively. Stability properties of a class of diffusion processes, constrained to take values in G, are studied under the assumption that the Skorokhod problem defined by the data {(n_i, d_i), i = 1, ..., N} is well posed and the Skorokhod map is Lipschitz continuous. Explicit conditions on the drift coefficient, b(\cdot), of the diffusion process are given under which the constrained process is positive recurrent and has a unique invariant measure. Define \C \Df{- \sum_{i=1}^N α_i d_i; α_i \ge 0, i \in \{1, ..., N}}. Then the key condition for stability is that there exists δ\in (0, \infty) and a bounded subset A of G such that for all x \in G\backslash A, b(x) \in \C and \dist(b(x), \partial \C) \ge δ, where \partial \C denotes the boundary of \C.
A search for X-ray absorbed sources in the 3XMM catalogue, using photometric redshifts and Bayesian spectral fits
Creators: name: Ruiz, A.
name: Georgantopoulos, I.
name: Corral, A.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Since its launch in 1999, the XMM-\textit{Newton} mission has compiled the largest catalogue of serendipitous X-ray sources, with the 3XMM being the third version of this catalogue. This is because of the combination of a large effective area (5000 $\rm cm^2$ at 1 keV) and a wide field of view (30 arcmin). The 3XMM-DR6 catalogue contains about 470,000 unique X-ray sources over an area of 982 $\rm deg^2$. A significant fraction of these (100,178 sources) have reliable optical, near/mid-IR counterparts in the SDSS, PANSTARRS, VIDEO, UKIDSS and WISE surveys. In a previous paper we have presented photometric redshifts for these sources using the TPZ machine learning algorithm. About one fourth of these (22,677) have adequate photon statistics so that a reliable X-ray spectrum can be extracted. Obviously, owing to both the X-ray counts selection and the optical counterpart constraint, the sample above is biased towards the bright sources. Here, we present XMMFITCAT-Z: a spectral fit catalogue for these sources using the Bayesian X-ray Analysis (BXA) technique. As a science demonstration of the potential of the present catalogue, we comment on the optical and mid-IR colours of the 765 X-ray absorbed sources with $N_\mathrm{H} > 10^{22}\,\mathrm{cm}^{-2}$. We show that a considerable fraction of X-ray selected AGN would not be classified as AGN following the mid-IR W1-W2 vs. W2 selection criterion. These are AGN with lower luminosities, where the contribution of the host galaxy to the MIR emission is non-negligible. Only one third of obscured AGN in X-rays present red colours or r-W2 > 6. Then it appears that the r-W2 criterion, often used in the literature for the selection of obscured AGN, produces very different X-ray absorbed AGN samples compared to the standard X-ray selection criteria.
description: 12 pages, 10 figures. Reproduced with permission from Astronomy & Astrophysics, \c{opyright} ESO
Integrative self-sorting of coordination cages based on ‘naked’ metal ions
Creators: name: Bloch, Witold M.
name: Clever, Guido H.
Publisher: name: Technische Universität Dortmund
Year: 2017
Subjects: subject: Integrative self-sorting
subject: Heteroleptic self assembly
subject: Multicomponent cage system
subject: Supramolecular chemistry
subject: 540

description: Coordination-driven self-assembly of metal ions and organic ligands has been extensively utilised over the past four decades to access a variety of nano-sized cage assemblies, with functions ranging from sensing and catalysis to drug delivery. Many of the reported examples, however, are highly symmetric architectures that contain one type of organic ligand carrying not more than a single functionality. This contrasts significantly with the level of structural and functional complexity encountered in biological macromolecular hosts, which are able to bind and chemically convert smaller molecules in their highly- decorated internal cavities. To address this disparity, rational approaches that facilitate heteroleptic assembly by regulating integrative self-sorting of metal ions and multiple ligand components have emerged. Among these, routes to access coordination cages from ‘naked’ metal cations that offer more than two coordination sites are still in early development, as the complexity of the self-sorted products in terms of composition and stereochemistry presents an entropic challenge. This feature article highlights recent progress in controlling integrative self-sorting of multi-component cage systems with a focus on structures composed of ‘naked’ metal cations and two different ligands. Once heteroleptic self-assembly strategies find a wider implementation in supramolecular design, the resultant interplay between tailored combinations of precisely positioned substituents promises enhanced functionality in nanoscale structures.
title: Online engineering education for manufacturing technology
title: is a remote experiment a suitable tool to teach competences for “Working 4.0”?
titleType: AlternativeTitle
Creators: name: Terkowsky, Claudius
name: Frye, Silke
name: May, Dominik
Publisher: name: Technische Universität Dortmund
Year: 2019
Subjects: subject: 300

description: The demands of modern industry contexts (so‐called Industry 4.0) are going to reshape the working world of future engineers. It seems obvious that these technological developments will affect higher education institutions with increasing intensity. For years, there has been a vivid discussion on the IT competences, which need to be developed by students in order to face emerging technology changes. To tackle the question regarding industry expectations towards future engineers, in this article a remote laboratory at a German university is analysed to identify potentials for future‐oriented teaching and learning in the light of the required competences for “Working 4.0”. Current scientific studies and industry agendas about Working 4.0 competences are identified, connected learning objectives are derived and the focused remote laboratory is linked to these objectives. As a result, it can be shown that this educational setting has the potential to reflect the complexity of Working 4.0. However, the results also show that the examined laboratory addresses only some of the competences in the context of Industry 4.0. Furthermore, it is argued in how far industry demands serve as the only basis for educational development efforts. The scientific studies and the industry agenda offer a limited and more political perspective on educational development. Nevertheless, based on the research in this article, it can be argued that remote labs (and online labs in general) have the potential to lift traditional laboratory‐based engineering education to a modern engineering education 4.0.
description: Eur J Educ;54(4)
Synergistic induction of apoptosis in a cell model of human leukemia K562 by nitroglycerine and valproic acid
Creators: name: Aalaei, Shahin
name: Mohammadzadeh, Mehdi
name: Pazhang, Yaghub
Publisher: name: Technische Universität Dortmund
Year: 2019
Subjects: subject: Apoptosis
subject: Combination therapy
subject: Cytotoxicity
subject: K562 cells
subject: Nitroglycerine
subject: Valproic acid
subject: 610

description: Nitroglycerin (NG), a nitric oxide donor, and valproic acid (VPA), an inhibitor of histone deacetylases, have impressive effects on numerous cancer cell lines. This study intended to evaluate synergistic effects of NG and VPA on cell viability and apoptosis in K562 cells. K562 cells were cultured in RPMI-1640 supplemented with 10 % heat-inactivated FBS. They were treated with different doses of NG, VPA and cisplatin for 24, 48, and 72 h, and MTT assay was performed to analyze cell viability. Also, Peripheral blood mononuclear cells (PBMC) were cultured in RPMI-1640 media and incubated with NG (200 μM), VAP (100 μM), NG+VPA (150 μM) and cisplatin (8 μM) to evaluate cytotoxicity. IC50 of the drugs, when they were applied separately and in combination, were calculated using the COMPUSYN software. DNA electrophoresis, TUNEL assay, and Hoechst staining were performed to investigate apoptosis induction. RT-PCR was used for the evaluation of apoptotic genes expression. The results of the MTT assay showed that cell viability decreased at all applied doses of NG and VPA. It was noticed that the cytotoxic effects of these drugs were dose- and time-dependent. Based on the COMPUSYN output, the combination of the drugs (VPA and NG) in a certain ratio concentration synergistically decreased cell viability. Cisplatin significantly decreased cell viability of PBMCs and K562 cells. Also, the combination drug had cytotoxic effect and significantly reduced viability of K562 cells compared with PBMCs and control cells. In the target cells treated with this combination, Bax and caspase-3 expression increased but Bcl-2 expression decreased. These results suggest that NG, VPA, and their combination decreased cell viability and induced apoptosis via the intrinsic apoptotic pathway. This study suggests that this combination therapy can be considered for further evaluation as an effective chemotherapeutic strategy for patients with chronic myeloid leukemia.
description: EXCLI Journal;Vol. 18 2019
ARE STATED PREFERENCES INVARIANT TO THE PROSPECT OF REAL-MONEY CHOICE?
Creators: name: Newell, Laurienne Whinstanley
name: Swallow, Stephen K.
name: Newell, Laurienne Whinstanley
name: Swallow, Stephen K.
Publisher: name: Unknown
Year: 2002
Subjects: Financial Economics

description: This paper reports on a choice experiment where respondents stated their preferences for different wetland parcels. The study used hypothetical surveys to measure respondents' preferences, but in one survey version respondents expected and received a follow-up question involving real monetary payments. The results indicate that those respondents who received hypothetical surveys that included a real-money question registered a different preference function from those respondents who received a survey that asked respondents to answer hypothetical questions only. The study finds that respondents may reverse their preferences for parcel attributes, such as public access to the parcel as related to presentation.
Constraining the Radii of Neutron Stars with Terrestrial Nuclear Laboratory Data
Creators: name: Li, Bao-An
name: Steiner, Andrew W.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Nuclear Theory (nucl-th)
subject: Astrophysics (astro-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Neutron star radii are primarily determined by the pressure of isospin asymmetric matter which is proportional to the slope of the nuclear symmetry energy. Available terrestrial laboratory data on the isospin diffusion in heavy-ion reactions at intermediate energies constrain the slope of the symmetry energy. Using this constraint, we show that the radius (radiation radius) of a 1.4 solar mass neutron star is between 11.5 (14.4) and 13.6 (16.3) km.
description: 11 pages, 3 figures; version to be published in Phys. Lett. B
Fiber Tracking Velocimetry for two-point statistics of turbulence
Creators: name: Brizzolara, Stefano
name: Rosti, Marco Edoardo
name: Olivieri, Stefano
name: Brandt, Luca
name: Holzner, Markus
name: Mazzino, Andrea
Publisher: name: arXiv
Year: 2020
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We propose and validate a novel experimental technique to measure two-point statistics of turbulent flows. It consists in spreading rigid fibers in the flow and tracking their position and orientation in time and therefore been named ``Fiber Tracking Velocimetry'' (FTV). By choosing different fiber lengths, i.e. within the inertial or dissipative range of scales, the statistics of turbulence fluctuations at the selected lengthscale can be probed accurately by simply measuring the fiber velocity at its two ends, and projecting it along the transverse-to-the-fiber direction. By means of fully-resolved direct numerical simulations and experiments, we show that these fiber-based transverse velocity increments are statistically equivalent to the (unperturbed) flow transverse velocity increments. Moreover, we show that the turbulent energy dissipation rate can be accurately measured exploiting sufficiently short fibers. The technique has been tested against standard Particle Tracking Velocimetry (PTV) of flow tracers with excellent agreement. Our technique overcomes the well-known problem of PTV to probe two-point statistics reliably because of the fast relative diffusion in turbulence that prevents the mutual distance between particles to remain constant at the lengthscale of interest. This problem, making it difficult to obtain converged statistics for a fixed separation distance, is even more dramatic for natural flows in open domains. A prominent example are oceanic currents, where drifters (i.e.~the tracer-particle counterpart used in field measurements) disperse quickly, but at the same time their number has to be limited to save costs. Inspired by our laboratory experiments, we propose pairs of connected drifters as a viable option to solve the issue.
description: 15 pages, 15 figures