cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Promotion of resource efficiency within SMEs in Central Europe: A pilot study of the EDIT Value Tool
Creators: name: Grevenstette, Philipp
Publisher: name: My University
Year: 2016
Subjects: subject: Effizienzsteigerung
subject: Ressourceneffizenz
subject: Abfall | Ressourcen
subject: Waste | Resources

description: This master thesis deals with the evaluation of the analysis tool EDIT Value (Eco-innovation Diagnosis and Implementation Tool for Increase of Enterprise Value) with respect to the tool’s pilot phase. The tool developed in the course of the EU project PRESOURCE (Promotion of Resource Efficiency in SMEs in Central Europe) to reveal potentials for increasing resource efficiency in small and medium-sized enterprises (SMEs) was tested in different SMEs within the six partner countries of PRESOURCE. The companies as well as the consultants implementing the tool were interviewed on their experiences with EDIT Value, thus providing the basis for the evaluation of the tool. To facilitate a structured interview one questionnaire each for the companies and the consultants was compiled addressing the questions of interests; whether the tool in fact succeeds in revealing potentials for increasing resource efficiency, whether it works holistically and need-driven as intended, whether unforeseen challenges occurred and after all how the tool was accepted by the companies and the consultants. On basis of the feedback from the companies and consultants eventually improvement measures regarding the tool were developed.
Stories of copyright policy: The shift to an innovation agenda and what it might mean
Creators: name: Weatherall, Kimberlee
Publisher: name: Swinburne
Year: 2024

description: Governments develop narratives, or themes, about what they are trying to achieve, and stakeholders who want law reform also employ stories and narratives to make their concerns resonate with a broader audience. This article is about narratives that work, and that don't work, in the copyright arena. It examines the failure of 'freedom of expression' to gain traction in government debates over copyright in 2004-2006, before turning to the increasing dominance of an Innovation and Digital Economy Agenda in discussions about copyright and intellectual property generally. Some implications of the Innovation Agenda are discussed.
Sensitivity of Diffusion-Weighted STEAM MRI and EPI-DWI to Infratentorial Ischemic Stroke
Creators: name: Khalil, Ahmed A.; Hohenhaus, Marc; Kunze, Claudia; Schmidt, Wolf; Brunecker, Peter; Villringer, Kersten; Merboldt, Klaus-Dietmar
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Objectives To assess the sensitivity of stimulated echo acquisition mode diffusion weighted imaging (STEAM-DWI) to ischemic stroke in comparison to echo-planar imaging diffusion weighted imaging (EPI-DWI) in the infratentorial compartment. Methods Fifty-seven patients presenting with clinical features of infratentorial stroke underwent STEAM-DWI, high-resolution EPI-DWI (HR-DWI, 2.5 mm slice thickness) and low-resolution EPI-DWI (LR-DWI, 5 mm slice thickness). Four readers assessed the presence of ischemic lesions and artifacts. Agreement between sequences and interobserver agreement on the presence of ischemia were calculated. The sensitivities of the DWI sequences were calculated in 45 patients with a confirmed diagnosis of infratentorial stroke. Results Median time from symptom onset to imaging was 24 hours. STEAM- DWI agreed with LR-DWI in 89.5% of cases (kappa = 0.72, p<0.0001) and with HR- DWI in 89.5% of cases (kappa = 0.68, p<0.0001). STEAM-DWI showed fewer intraparenchymal artifacts (1/57) than HR-DWI (44/57) and LR-DWI (41/57). Ischemia was visible in 87% of cases for LR-DWI, 93% of cases for HR-DWI, and 89% of cases for STEAM-DWI. Interobserver agreement was good for STEAM-DWI (kappa = 0.62, p<0.0001). Conclusions Compared to the best currently available MR sequence for detecting ischemia (HR-DWI), STEAM-DWI shows fewer artifacts and a similar sensitivity to infratentorial stroke.
title: Advancing REACH - consultation procedures
title: Advancing REACH - consultation procedures
titleType: AlternativeTitle
Creators: name: Wirth, Olaf
name: Jepsen, Dirk
Publisher: name: Umweltbundesamt
Year: 2021
Subjects: subject: REACH-System
subject: Anhörungsverfahren
subject: REACH
subject: consultation procedure
subject: Chemicals

description: Dieser Bericht ist Teil des Ressortforschungsplan Vorhabens "REACH-Weiterentwicklung", das basierend auf Analysen verschiedener REACH-Prozesse sowie angrenzender Fragestellungen (Substitution, Nachhaltige Chemie, Vorsorgeprinzip, Erzeugnisse, Kosten-Nutzen Analysen, Sozio-Ökomische Analysen, Finanzierung der ECHA) Optionen für eine Verbesserung der (Umsetzung der) REACH-Verordnung entwickelte. In diesem Teilprojekt wurden die Konsultationsverfahren nach REACH bzgl. ihrer Effektivität, Effizienz und Transparenz analysiert. Außerdem wurden die "Calls for Evidence", welche die ECHA z. T. vor Beschränkungsvorschlägen durchführt und die Konsultationen von einigen Mitgliedstaaten im Rahmen einer RMOA berücksichtigt. Insgesamt sind die Konsultationen hilfreiche Instrumente, um Information zu erheben. Allerdings, sind sie insbesondere für die Sammlung von Daten über Alternativen nicht ausreichend, so dass teilweise weitere Maßnahmen zur Erhebung von Informationen notwendig sind. Quelle: Forschungsbericht
description: This report is provided in the scope of the project "Advancing REACH", funded by the research plan of the German Ministry for the Environment. The project aims to develop options to improve the (implementation of) the REACH regulation by analysing various REACH processes and related issues, including substitution, sustainable chemistry, precautionary principle, articles, cost-benefit analyses, socio-economic analyses and financing ECHA. In this sub-project, the consultation procedures foreseen under REACH were analysed with regard to their effectiveness, efficiency and transparency. In addition, the "Call for Evidence" preceding some of ECHA's restriction proposals and the consultations supporting an RMOA were assessed. Overall, the consultations are considered as helpful instruments to collect information. However, in particular the data on alternatives gathered through consultations is not sufficient and additional measures may be needed to collect sufficient information. Quelle: Forschungsbericht
description: Public consultation is a very important process for a better participation and takes place on a voluntary basis. For ⁠REACH⁠, several public consultation procedures were therefore incorporated as part of the different REACH processes, such as substance evaluations, substance identifications, restrictions or authorisation procedures. The different consultation procedures and their requirements foreseen under REACH were analysed with regard to their effectiveness, efficiency and transparency. In addition, the “Call for Evidence” preceding some of ECHA’s restriction proposals and the consultations supporting an RMOA were assessed.
title: On to vict'ry, strike up the band!
title: a history of the Auburn University band program from 1991 to 2021
titleType: Subtitle
Creators: name: Strickland, Tyler Lee
Publisher: name: University of Iowa
Year: 2022
Subjects: AUBURN
BAND HISTORY
CONCERT BAND
MARCHING BAND
SOUTHEASTERN CONFERENCE
WIND BAND
public abstract

description: This thesis is an historical account of the band program at Auburn University from 1991–2021. The Auburn University Band Program has experienced a long history of rich traditions and continued excellence, so much so that the school’s fight song even contains the line “On to vict’ry, strike up the band.” What started as a small ensemble accompanying military exercises on campus in 1897, has grown into a band program that is respected both nationally and internationally. The renown of the program at Auburn has increased significantly in the past thirty years through the work and commitment of Directors of Bands, Johnnie Vinson and Rick Good. The athletic bands have also seen significant improvement and received recognition through the work of John Roscigno, Tim Kelley, Greg Byrne, Rick Good, Troy Breaux, Doug Rosener, Corey Spurlin, and Nikki Gross.
description: Since 1991, the concert bands have performed at American Bandmasters Association (ABA) conventions twice, a College Band Directors National Association (CBDNA) regional conference, numerous Alabama state conferences, and have toured internationally twice. The marching band has performed at two national championship games, numerous other bowl games, and has been selected for viewing at CBDNA conferences three times due to the precision and innovation of their shows.
description: Numerous changes have occurred over the course of thirty years: changes to audition procedures, recruiting tactics, uniforms, facilities, pregame performances. However, the stability that has been provided through the lengthy tenures of Johnnie Vinson, Rick Good, Doug Rosener, Corey Spurlin, and Nikki Gross has also been crucial in the continued development and improvement of the bands.
Energy Management in Smart Cities Based on Internet of Things: Peak Demand Reduction and Energy Savings
Creators: name: Mahapatra, Chinmaya
name: Moharana, Akshaya Kumar
name: Leung, Victor Chung Ming, 1955-
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Around the globe, innovation with integrating information and communication technologies (ICT) with physical infrastructure is a top priority for governments in pursuing smart, green living to improve energy efficiency, protect the environment, improve the quality of life, and bolster economy competitiveness. Cities today faces multifarious challenges, among which energy efficiency of homes and residential dwellings is a key requirement. Achieving it successfully with the help of intelligent sensors and contextual systems would help build smart cities of the future. In a Smart home environment Home Energy Management plays a critical role in finding a suitable and reliable solution to curtail the peak demand and achieve energy conservation. In this paper, a new method named as Home Energy Management as a Service (HEMaaS) is proposed which is based on neural network based Q-learning algorithm. Although several attempts have been made in the past to address similar problems, the models developed do not cater to maximize the user convenience and robustness of the system. In this paper, authors have proposed an advanced Neural Fitted Q-learning method which is self-learning and adaptive. The proposed method provides an agile, flexible and energy efficient decision making system for home energy management. A typical Canadian residential dwelling model has been used in this paper to test the proposed method. Based on analysis, it was found that the proposed method offers a fast and viable solution to reduce the demand and conserve energy during peak period. It also helps reducing the carbon footprint of residential dwellings. Once adopted, city blocks with significant residential dwellings can significantly reduce the total energy consumption by reducing or shifting their energy demand during peak period. This would definitely help local power distribution companies to optimize their resources and keep the tariff low due to curtailment of peak demand.
Identifying drivers of Barred Owl (Strix varia) occupancy along a gradient of urbanization in a primarily agricultural region
Creators: name: Alex, Nicholas
Publisher: name: University of Iowa
Year: 2022
Subjects: subject: Barred Owl
subject: Habitat Selection
subject: Occupancy Modeling
subject: Urbanization
subject: Biology
subject: public abstract
subject: Ecology
subject: FOS: Biological sciences
subject: Wildlife

description: Earth’s terrestrial systems are now overwhelmingly anthropogenic, sacrificing the ability of these systems to support a diverse set of species. For example, in regions that have been transformed to intensive agriculture, little habitat remains to support forest species, leading to dramatic declines in these species. Urbanized areas embedded in these settings contain forested green spaces and accrue trees via planting. Such cities may thus provide key habitat to support the persistence of forest species. However, few studies have explored this potential and we currently lack a basic understanding of the role cities in agricultural regions may play in biodiversity conservation. We sought to build this understanding by empirically identifying basic habitat relationships for Barred Owls (Strix varia), nocturnal forest owls in urban areas in the US Corn Belt, a region of intensive row-crop agriculture. We focused on two metropolitan areas in Eastern Iowa, USA, Iowa City and Cedar Rapids, that are surrounded by an extensive row-crop matrix. We combined data from call-back surveys of these owls with land-cover and urban forest data for 500 m survey plots to construct occupancy models to identify key attributes of habitat for this species in this setting. Our top models included two covariates, urban intensity as indicated by impervious cover and cropland cover, both with negative relationships to Barred Owl occupancy, with a considerably stronger negative relationship for agricultural cover. Contrary to our expectations, a covariate constructed to indicate the presence of mature trees was not included in our top models and thus was not related to Barred Owl occupancy. Predicted Barred Owl occupancy rates remained relatively high (up to 40%) up to the mean urban intensity of our study area but dropped precipitously to nearly 0% when agricultural cover exceeded 30%. Given that landscapes surrounding cities in this region are comprised of nearly 100% row-crop agriculture, this finding suggests that urbanized areas in the study area may provide better Barred Owl habitat than the extensive cropland that surrounds them. These results indicate that urban areas may be important sites of Barred Owl conservation in intensively agricultural regions.
40 ans sur la route: L'évolution de la représentation de la femme dans le roman de la route au Québec de 1964 à 2004
Creators: name: Legault, Céline
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Literature, Canadian (French).
subject: Women's Studies.

description: Lorsque l'on parle des romans de la route, l'exemple canonique qui vient à l'esprit est certainement On the Road de Jack Kerouac, le roman culte de la génération beatnik publié en 1957. Au Québec, les origines canadiennes-françaises de Jack Kerouac lui ont assuré une grande popularité et plusieurs auteurs québécois ont repris le genre road novel. Une lecture au féminin des romans de la route québécois permet de constater que ces récits sont très masculins puisqu'ils sont (en majorité) écrits par des hommes, et que les personnages principaux sont aussi presque exclusivement des hommes. Or, les personnages féminins sont tout de même présents et significatifs dans ce genre de récit. Le présent travail étudie le rôle et la représentation de ces personnages féminins sur la route pendant une période de quarante ans. Plusieurs ouvrages traitant de la lecture au féminin ont été utilisés pour les recherches effectuées. Les travaux de Lori Saint-Martin et de Michele Coquillat, entre autres, ont éclairé nos réflexions sur la représentation du personnage féminin, et d'autres ouvrages comme celui de Susan Sniader Lanser ont contribué aux analyses en ce qui concerne la voix narrative. De plus, la coupe des chapitres permet de cibler certaines tendances dans la représentation de la femme, selon la date à laquelle un roman a été publié. Cette chronologie met en lumière, donc, une certaine évolution du rôle joué par les femmes dans les narrations masculines.
Ion/radical and ion/molecule complexes and ion structure assignments in the gas phase.
Creators: name: Bissonnette, Martine C.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1991
Subjects: subject: Chemistry, Organic.

description: The fragmentation mechanism of ionized neopentanol, (CH$\sb3$)$\sb3$CCH$\sb2$OH$\sp{+-}$, has been studied in great detail along with other C$\sb5$H$\sb $H$\sp{+-}$ isomers. The use of $\sp $C and D labelling was found an essential tool to establish the relation between the other species involved in the dissociation of neopentanol. The involvement of (CH$\sb3$)$\sb2$C$\sp{\cdot}$CH$\sb2\sp+$(O)HCH$\sb3$, (CH$\sb3$)$\sb3$C$\sp+$(O)HCH$\sb2$ and (CH$\sb3$)$\sb2$($\sp\cdot$CH$\sb2$)CCH$\sb2\sp+$OH$\sb2$ was essential to explain the H/D label exchange occurring upon fragmentation of neopentyl alcohol. An ion-dipole complex between methanol and ionized methyl propene is proposed as the final intermediate which leads directly to the products, methanol and ionized methyl propene. The results of the investigation of C$\sb7$H$\sb5\sp+$ ions from various precursor molecules are also described. The following compounds, which all produce C$\sb7$H$\sb5\sp+$ ions, were studied: benzyl acetate, benzyl formate, benzyl alcohol, 2-bromocyclopropabenzene, 1,6-heptadiyne and 1,5-decadiyne. According to the metastable ion (MI) mass spectra and the He collision induced dissociation (CID) of m/z 89 ions, it is suggested that four structures exist. (Abstract shortened by UMI.)
Die Genehmigung wissenschaftlicher Forschung in der Antarktis im Lichte von Umweltschutz und Forschungsfreiheit - Rechtsgutachten - Schwerpunkt 7 "Ausgestaltung des Post 2012 - Klimaregimes und internationaler Umweltschutz"
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2013

description: Die Studie gibt Antworten auf eine Vielzahl von Detailfragen zum Genehmigungsregime für Tätigkeiten in der Antarktis. Zusammengefasst ergibt sich dabei, dass die Genehmigungspraxis des Umweltbundesamtes sowohl den Vorgaben des Umweltschutzprotokolls zum Antarktisvertrag als auch den darüber teilweise noch hinausgehenden Regelungen des Ausführungsgesetzes entspricht. Verfahren und Ergebnisse dieser Genehmigungspraxis entsprechen den Maßgaben des Vorsorgeprinzips, dass in den Regelungen zum antarktischen Umweltschutz verankert ist. Das Vorsorgeprinzip eröffnet der Genehmigungsbehörde einen weiten Einschätzungs- und Beurteilungsspielraum, der gerichtlich nur begrenzt überprüfbar ist. Dies gilt auch in den Fällen, in denen die Genehmigungsbehörde Tätigkeiten Grenzen setzt, die - wie die wissenschaftliche Forschung - ihrerseits durch das Rechtsregime des Antarktisvertrages und durch verfassungsrechtliche Vorgaben besonders privilegiert werden.
description: The study provides answers to a number of detailed questions about the licensing regime for activities in Antarctica. Results summarized here show that the licensing practices of the Federal Environment Agency respect both the requirements of the Protocol on Environmental Protection to the Antarctic Treaty and of the German Act Implementing the Environmental Protocol. Procedures and results of these licensing practices comply with the stipulations of the precautionary principle, enshrined in the regulations of the Protocol and the implementing German legislation. The precautionary principle allows the licensing authority a broad margin of assessment and discretion, thereby limiting the legal review of the courts. This also applies in cases where the licensing authority shall limit activities of scientific research, which are privileged by the legal regime of the Antarctic Treaty and by German constitutional guaranties.
Recognizing difficult trade-offs: values and treatment preferences for end-of-life care in a multi-site survey of adult patients in family practices
Creators: name: Howard, Michelle
name: Bansback, Nick
name: Tan, Amy
name: Klein, Doug
name: Bernard, Carrie
name: Barwich, Doris
name: Dodek, Peter M.
name: Nijjar, Aman
name: Heyland, Daren K.
Publisher: name: BioMed Central
Year: 2017

description: Background: Decisions about care options and the use of life-sustaining treatments should be informed by a person’s values and treatment preferences. The objective of this study was to examine the consistency of ratings of the importance of the values statements and the association between values statement ratings and the patient’s expressed treatment preference. Methods: We conducted a multi-site survey in 20 family practices. Patients aged 50 and older self-completed a questionnaire assessing the importance of eight values (rated 1 to 10), and indicated their preference for use of life-sustaining treatment (5 options). We compared correlations among values to a priori hypotheses based on whether the value related to prolonging or shortening life, and examined expected relationships between importance of values and the preference option for life-sustaining treatment. Results: Eight hundred ten patients participated (92% response rate). Of 24 a priori predicted correlations among values statements, 14 were statistically significant but nearly all were negligible in their magnitude and some were in the opposite direction than expected. For example, the correlation between importance of being comfortable and suffering as little as possible and the importance of living as long as possible should have been inversely correlated but was positively correlated (r = 0.08, p = 0.03). Correlations between importance of values items and preference were negligible, ranging from 0.03 to 0.13. Conclusions: Patients may not recognize that trade-offs in what is most important may be needed when considering the use of treatments. In the context of preparation for decision-making during serious illness, decision aids that highlight these trade-offs and connect values to preferences more directly may be more helpful than those that do not.
Streamlining human data access — Implementing GA4GH Passport
Creators: name: Linden, Mikael
name: Nyrönen, Tommi
name: Kuba, Martin
name: Procházka, Michal
name: Dyke, Stephanie
Publisher: name: F1000 Research Limited
Year: 2020

description: The Global Alliance for Genomics and Health (GA4GH) is a policy framing and technical standards setting organization, seeking to enable responsible genomic data sharing within a human rights framework. Researcher Passport is a GA4GH standard describing a researcher’s permissions to access services in the registered and controlled access tiers. ELIXIR has contributed to the standardization work in the GA4GH’s DURI (Data Use and Researcher Identities) workstream and implemented the Passports. ELIXIR AAI, the ELIXIR Identity and Access Management service, intends to be a trusted Passport broker for its constituency. The GA4GH Passports can be used to enforce access to services, for instance, together with other GA4GH specifications.
Part I: Derivatives of 7-azabicyclo[2.2.1]heptane. Part II: Base catalysed hydrogen:deuterium exchange of benzyl sulfoxides.
Creators: name: Swingle, R. B.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1969
Subjects: subject: Chemistry, Organic.

description: Part I. The synthesis of 7-azabicyclo[2.2.1]heptane (ABH) has been accomplished via two new synthetic routes both of which provide improved yields over any previous synthesis. The spectral and chemical properties of several N-substituted ABH derivatives have been studied and the rotation barriers for 7-acetyl-7-azabicyclo-[2.2.1]heptane and 7-nitroso-7-azabicyclo[2.2.1]heptane have been determined. Chlorination of the trichloroacetyl derivative of ABH and subsequent removal of the trichloroamide group gave a mono-chloro derivative whose structure was proven to be exo-2-chloro-7-azabicyclo[2.2.1]heptane. The solvolytic behavior of this derivative was briefly examined. A new reaction of trichloroacetyl chloride with triethylamine was discovered and was shown to produce a beta-acylenamine. A probable mechanism was proposed after an extensive investigation of the reaction. Part II. The rates of hydrogen:deuterium exchange for the diastereotopic methylene protons in the benzyl group of three benzyl sulfoxides have been determined using mass spectrometry. The variation in rates with changes in structure were found to be small.
Temporal trends of lipophilic organic contaminants in blue mussel (1994-2017) and eelpout (1994-2017) from the southern Baltic Sea
Creators: name: Rebryk, Andriy
name: Koschorreck, Jan
name: Haglund, Peter
Publisher: name: My University
Year: 2023

description: A time-trend study was carried out for two important Baltic Sea species, blue mussel (1994-2017, 11 samples) and eelpout (1994-2017, 11 samples), to track the changes in levels of regulated persistent organic pollutants (POPs) and show potential increases in the levels of the contaminants of emerging concern (CECs). It was carried out utilizing gas chromatography-high-resolution mass spectrometry (GC-HRMS) based non-target screening (NTS). Data were acquired in two modes - electron ionization (EI) and electron capture negative ion chemical ionization (ECNI) to widen the contaminant coverage, and treated using a fast semi-automated NTS data processing workflow. The study revealed that >250 tentatively identified compounds show statistically significant temporal trends in Baltic blue mussel and eelpout. A large number of regulated substances, including but not limited to PCBs, DDTs and other organochlorine pesticides (OCPs), chlorobenzenes, and many polybrominated diphenyl ethers (PBDEs), showed significant declining trends, as was expected. Their rates of decline were in good agreement with previously reported data. In contrast, increasing trends were observed for many CECs, some polycyclic aromatic compounds (PAHs), and hydrocarbons. The CEC group included, among others, four compounds, namely, one personal care product ingredient, 2-ethylhexyl stearate, one brominated compound 1,2,3,5-tetrabromobenzene and two intermediates 4-isopropoxyaniline and bilobol dimethyl ether, that were reported in marine biota for the first time to the best of our knowledge. Several compounds, including four CECs and two unknown brominated compounds, showed levels considerably higher than the common legacy pollutants (CB-153 and BDE-99), which might be taken into consideration for future monitoring and risk assessment. In addition, this work revealed the presence of a plethora of organoiodinated compounds that exhibited statistically significant temporal trends in the samples under study, which could be of future interest. © 2023 The Authors
Own-race and own-age biases facilitate visual awareness of faces under interocular suppression
Creators: name: Stein, Timo
name: End, Albert
name: Sterzer, Philipp
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 100 Philosophie und Psychologie::150 Psychologie

description: The detection of a face in a visual scene is the first stage in the face processing hierarchy. Although all subsequent, more elaborate face processing depends on the initial detection of a face, surprisingly little is known about the perceptual mechanisms underlying face detection. Recent evidence suggests that relatively hard-wired face detection mechanisms are broadly tuned to all face-like visual patterns as long as they respect the typical spatial configuration of the eyes above the mouth. Here, we qualify this notion by showing that face detection mechanisms are also sensitive to face shape and facial surface reflectance properties. We used continuous flash suppression (CFS) to render faces invisible at the beginning of a trial and measured the time upright and inverted faces needed to break into awareness. Young Caucasian adult observers were presented with faces from their own race or from another race (race experiment) and with faces from their own age group or from another age group (age experiment). Faces matching the observers’ own race and age group were detected more quickly. Moreover, the advantage of upright over inverted faces in overcoming CFS, i.e., the face inversion effect (FIE), was larger for own-race and own-age faces. These results demonstrate that differences in face shape and surface reflectance influence access to awareness and configural face processing at the initial detection stage. Although we did not collect data from observers of another race or age group, these findings are a first indication that face detection mechanisms are shaped by visual experience with faces from one’s own social group. Such experience-based fine-tuning of face detection mechanisms may equip in-group faces with a competitive advantage for access to conscious awareness.
Investigating contributions of hydrogen peroxide to radiation-induced arthrofibrosis
Creators: name: Rodman, Samuel Nathan
Publisher: name: University of Iowa
Year: 2022
Subjects: Fibrosis
Orthopedic
Radiation
public abstract
Injury

description: Radiation treatment can injure normal tissue and result in painful and debilitating fibrosis in and around joint spaces. A mouse model was developed to study the initiation and progression of radiation-induced arthrofibrosis. Analysis of individual mouse gaits over 22 weeks following radiation therapy revealed that mice typically maintain a steady gait but reduce their base of support in the hindlimbs over time. Mice do develop physiological, quantifiable differences in their irradiated and unirradiated limbs including resting angle of the stifle and leg shortening, starting at 8 weeks. This indicates a potential therapeutic window for patients as well, and future studies will focus on delivering therapy to mice during this window. In a second, larger study with a 12-week endpoint, the stifle capsule was shown to be significantly thicker in the irradiated leg compared to the unirradiated leg. Immunohistochemical analysis showed intense staining for alpha smooth muscle actin (α-SMA) in the fat pad. NADPH oxidase 4 (NOX4) expression was higher in the group that received a large dose of radiation compared to the group that received fractionated doses. For both α-SMA and NOX4, expression was significantly higher in females compared to males. CD34, a marker for stem-like preadipocytes, was decreased in irradiated legs compared to contralateral, indicating a decrease in the preadipocyte population near the injury. To further investigate preadipocyte differentiation, immortalized preadipocytes were used in culture. Radiation reduced adipogenesis over the 10 days following exposures of 2 Gy and 4 Gy. Continuous exposure to hydrogen peroxide generated by glucose oxidase (GOx) for 10 days also reduced the adipogenic capacity of these cells. Adenoviral transduction of catalase was able to significantly rescue the decreased adipogenic capacity at a high dose of GOx, compared to empty vector control virus and sham treated cells. These findings suggest that oxidative stress in adipose tissue is a target for therapy in radiation-induced arthrofibrosis, female patients may be at a higher risk for developing fibrosis around joint spaces after radiation, and that the window for interventional treatment might be during the 8 weeks following the completion of radiation therapy.
Proposal for regulatory risk mitigation measures for human pharmaceutical residues in the environment
Creators: name: Moermond, Caroline T.A.
name: Berg, Cecilia
name: Bergstrom, Ulrika
name: Gildemeister, Daniela
Publisher: name: My University
Year: 2023
Subjects: Umwelt
Wassergüte
Genehmigung

description: Environmental risks of human pharmaceutical products should be made transparent and mitigated as far as possible. We propose to apply a risk mitigation scheme to the marketing authorisation of human medicinal products which is pragmatic and tailored, and thus will not increase the burden to regulators and industry too much. This scheme takes into account increasing knowledge and accuracy of the environmental risk estimates, applying preliminary risk mitigation when risks are determined based on model estimates, and definitive, more strict and far-reaching risk mitigation when risks are based on actual measured environmental concentrations. Risk mitigation measures should be designed to be effective, proportional, easy to implement, and in line with current (other) legislation, as well as not being a burden to the patient/health care professionals. Furthermore, individual risk mitigation measures are proposed for products showing environmental risks, while general risk mitigation measures can be applied to all products to reduce the overall burden of pharmaceuticals in the environment. In order to effectively mitigate risk, linking marketing authorisation legislation to environmental legislation is essential. © 2023 The Authors
Regional geophysical modelling and paleo-reconstruction in and around the southern Slave Structural Province.
Creators: name: Shepley, Karen Anne Bernice.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Geophysics.

description: The rocks of northwestern Canada represent over 4.0 Ga of geological history. This study focuses on two periods from that history: geophysical modeling in the south-central Archean Slave Structural Province and a reconstruction of the Early Proterozoic Great Slave Lake Shear Zone (GSLSZ) using the regional magnetic fabric. One of the goals of the modelling in the Slave Province was to constrain the depth extent and shapes of the exposed plutons and greenstone belts. The reconstruction of the GSLSZ was performed using a technique developed by Roest and Pilkington (1994). First, the effects of the Bathurst and MacDonald Fault Zones were removed. Reconstruction of the GSLSZ was performed using the regional magnetic fabric after the removal of the effects of the Bathurst and MacDonald Fault Zones. One possible combination of plate geometries is assumed. Although widely separated in time, the two tectonic phases addressed in this study depicts two phases in the process of craton formation. (Abstract shortened by UMI.)
Environmentally harmful subsidies in Germany
Creators: name: Bretschneider, Wolfgang
name: Burger, Andreas
Publisher: name: Umweltbundesamt
Year: 2022
Subjects: subject: Finanzpolitik
subject: Ökologische Finanzreform
subject: Environmentally harmful subsidies
subject: fiscal policy
subject: Sustainable budgeting
subject: Green Budgeting
subject: ecological fiscal reform
subject: Climate | Energy
subject: Economy | Consumption
subject: Air
subject: Waste | Resources
subject: Health
subject: Water

description: The report provides an overview of environmentally harmful subsidies in Germany and makes proposals for their reform or reduction. It focuses on subsidies that have a negative impact on the environmental goods climate, air, soil, water, biodiversity and landscape, as well as on health and the consumption of raw materials. The report analyzes subsidies and their environmental impacts in the areas of energy supply and use, transport, housing, as well as agriculture, forestry and fisheries. It focuses on the most important federal subsidies and only marginally considers subsidy programs at the state and municipal level. Quelle: www.umweltbundesamt.de
description: The report provides an overview of environmentally harmful subsidies in Germany and makes proposals for their reform or reduction. It focuses on subsidies that have a negative impact on the environmental goods climate, air, soil, water, biodiversity and landscape, as well as on health and the consumption of raw materials. The report analyzes subsidies and their environmental impacts in the areas of energy supply and use, transport, housing, as well as agriculture, forestry and fisheries. It focuses on the most important federal subsidies and only marginally considers subsidy programs at the state and municipal level.
Operationalizing mHealth to improve patient care: a qualitative implementation science evaluation of the WelTel texting intervention in Canada and Kenya
Creators: name: Bardosh, Kevin
name: Murray, Melanie C. M.
name: Khaemba, Antony M.
name: Smillie, Kirsten
name: Lester, Richard T.
Publisher: name: BioMed Central
Year: 2017

description: Background: Mobile health (mHealth) applications have proliferated across the globe with much enthusiasm, although few have reached scale and shown public health impact. In this study, we explored how different contextual factors influenced the implementation, effectiveness and potential for scale-up of WelTel, an easy-to-use and evidence-based mHealth intervention. WelTel uses two-way SMS communication to improve patient adherence to medication and engagement in care, and has been developed and tested in Canada and Kenya. Methods: We used a comparative qualitative case study design, which drew on 32 key informant interviews, conducted in 2016, with stakeholders involved in six WelTel projects. Our research was guided by the Consolidated Framework for Implementation Research (CFIR), a meta-theoretical framework, and our analysis relied on a modified approach to grounded theory, which allowed us to compare findings across these projects. Results: We found that WelTel had positive influences on the “culture of care” at local clinics and hospitals in Canada and Kenya, many of which stretched beyond the immediate patient-client relationship to influence wider organizational systems. However, these were mediated by clinician norms and practices, the availability of local champion staff, the receptivity and capacity of local management, and the particular characteristics of the technology platform, including the ability for adaptation and co-design. We also found that scale-up was influenced by different forms of data and evidence, which played important roles in legitimization and partnership building. Even with robust research evidence, scale-up was viewed as a precarious and uncertain process, embedded within the wider politics and financing of Canadian and Kenyan health systems. Challenges included juggling different interests, determining appropriate financing pathways, maintaining network growth, and “packaging” the intervention for impact and relevance. Conclusions: Our comparative case study, of a unique transnational mobile health research network, revealed that moving from mHealth pilots to scale is a difficult, context-specific process that couples social and technological innovation. Fostering new organizational partnerships and ways of learning are paramount, as mHealth platforms straddle the world of research, industry and public health. Partnerships need to avoid the perils of the technological fix, and engage the structural barriers that mediate people’s health and access to services.
A top-down look into the performance of web applications
Creators: name: Ahmed, Adnan
Publisher: name: University of Iowa
Year: 2024
Subjects: Computer Networks
Data driven
Measurement
Performance
World Wide Web
public abstract

description: The Internet ecosystem primarily consists of content publishers who generate web content, end-users who consume the content, and Internet Service Providers who connect them. Since content publishers and Internet Service Providers primarily generate revenue from advertisements and subscriptions, good user experience and high user engagement is of utmost importance. Consequently, measuring and improving the performance of web and the Internet has been an active area of research in the past decade.
description: In this thesis, we develop techniques to measure the performance of web applications and the underlying network. Notably, we first design scalable and deployable measurement approaches to characterize the end-to-end network performance. We analyze the performance aspects of various interconnection strategies adopted by networks, over a large-scale longitudinal measurement study. Additionally, we design a measurement framework that facilitates the deployment of various network measurement techniques with otherwise high network overheads, by leveraging useful application traffic and mitigating the associated network overheads.
description: In addition to network performance measurements, we also develop approaches to characterize and measure the performance of web applications such as web browsing and video streaming. Specifically, we design a server-side approach to characterize the performance of live video streaming by analyzing HTTP request logs collected at the web servers. We further design an approach to identify the groups of end-users who are experiencing bad QoE metrics in real-time, thereby allowing the stakeholders to take immediate mitigation steps. Next, we design a server-side technique to facilitate the implementation of HTTP/2 server push, allowing content providers to improve web page performance by preemptively sending web content to the end-user without waiting for explicit requests. Finally, we conduct a measurement study to analyze the adherence to best practices across modern web pages. Finally, we study the usage of standardized HTML performance attributes to control the loading and execution of resources on modern web pages, and their impact on web performance.
Replication files for "Citizens ditching cars: How do assessments of social-ecological interactions predict a modal shift towards low-carbon urban transport choices?" by Myriam Pham-Truffert, Mario Angst, Thomas Breu and Maria J. Santos (2025)
Creators: name: Pham-Truffert, Myriam
name: Angst, Mario
Publisher: name: Zenodo
Year: 2025

description: We document the proper use of the replication files of our manuscript called “Citizens ditching cars: How do assessments of social-ecological interactions predict a modal shift towards low-carbon urban transport choices?”, which we submitted on the 20th of February 2025 to IOP’s Environmental Research Letters.

We report the required environment for the computation, our rights to use the data, and the procedure to reproduce our analysis. 
description: This research was supported by the DIZH, Digitalisierungsinitiative der Zürcher Hochschulen.
Digital Qualifiziert - Georg Schütte
Creators: name: (:Unkn) Unknown
Publisher: name: Max-Planck-Gesellschaft zur Förderung der Wissenschaften
Year: 2021

description: Unser heutiger Gast ist Georg Schütte. Als Generalsekretär der Volkswagenstiftung vertritt er den größten privaten Forschungsförderer in Deutschland. Und als ehemaliger Staatssekretär im Bundesministerium für Bildung und Forschung kennt er sich bestens in der akademischen Landschaft aus. In unserem Gespräch versuche wir zu klären, warum Kreativität im Digitalen besonders wichtig ist, wie sich Architektur mit der Digitalisierung verändern könnte und warum 2020 ein Weckruf war. Quelle: www.soundcloud.com
Treatment of Chronic Experimental Autoimmune Encephalomyelitis with Epigallocatechin-3-Gallate and Glatiramer Acetate Alters Expression of Heme- Oxygenase-1
Creators: name: Janssen, Antonia
name: Fiebiger, Sebastian
name: Bros, Helena
name: Hertwig, Laura
name: Romero-Suarez, Silvina
name: Hamann, Isabell
name: Chanvillard, Coralie
name: Bellmann-Strobl, Judith
name: Paul, Friedemann
name: Millward, Jason M.
name: Infante-Duarte, Carmen
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: We previously demonstrated that epigallocatechin-3-gallate (EGCG) synergizes with the immunomodulatory agent glatiramer acetate (GA) in eliciting anti- inflammatory and neuroprotective effects in the relapsing-remitting EAE model. Thus, we hypothesized that mice with chronic EAE may also benefit from this combination therapy. We first assessed how a treatment with a single dose of GA together with daily application of EGCG may modulate EAE. Although single therapies with a suboptimal dose of GA or EGCG led to disease amelioration and reduced CNS inflammation, the combination therapy had no effects. While EGCG appeared to preserve axons and myelin, the single GA dose did not improve axonal damage or demyelination. Interestingly, the neuroprotective effect of EGCG was abolished when GA was applied in combination. To elucidate how a single dose of GA may interfere with EGCG, we focused on the anti- inflammatory, iron chelating and anti-oxidant properties of EGCG. Surprisingly, we observed that while EGCG induced a downregulation of the gene expression of heme oxygenase-1 (HO-1) in affected CNS areas, the combined therapy of GA+EGCG seems to promote an increased HO-1 expression. These data suggest that upregulation of HO-1 may contribute to diminish the neuroprotective benefits of EGCG alone in this EAE model. Altogether, our data indicate that neuroprotection by EGCG in chronic EAE may involve regulation of oxidative processes, including downmodulation of HO-1. Further investigation of the re-dox balance in chronic neuroinflammation and in particular functional studies on HO-1 are warranted to understand its role in disease progression.
Structures and non-canonical functions of E3 ubiquitin ligases in DNA damage bypass
Creators: name: Ling, Justin A.
Publisher: name: University of Iowa
Year: 2024
Subjects: public abstract

description: DNA damage is caused by several different sources, such as ultraviolet and ionizing radiation and many chemicals found in the environment. DNA damage is extremely problematic because it interferes with DNA replication, thus leading to mutations, genomic instability, and ultimately cell death. To prevent DNA damage from interfering with DNA replication, eukaryotes possess multiple DNA damage bypass pathways, such as translesion synthesis and template switching. Both of these DNA damage bypass pathways are regulated through the ubiquitylation of the homo-trimeric sliding clamp, proliferating cell nuclear antigen (PCNA). In translesion synthesis and template switching, there are two E3 ubiquitin ligases that are responsible for the ubiquitylation of PCNA: Rad18 and Rad5. Rad18 and Rad5 possess both a canonical role (ubiquitylating PCNA) and a non-canonical role. However, the non-canonical roles of Rad18 and Rad5 are unknown.
description: First, Rad5 is a fork-reversal helicase. Little is known mechanistically of Rad5’s helicase activity, so I wanted to determine the optimal substrate for Rad5. I found that Rad5 preferentially reverses fork DNA substrates with short gaps (10 to 30 nt.) in the leading strand. Thus, Rad5 preferentially reverses fork DNA substrates that form chicken foot intermediates with 5’ overhangs that can be extended by replicative DNA polymerases during the subsequent steps of template switching. I also showed that Rad5 is both a DNA-DNA helicase and an RNA-DNA helicase. Furthermore, I found that Rad5 binds fork DNA substrates in a 1:1 ratio. Lastly, I found that RPA reduces the rate of fork reversal in some, but not all substrates. In conclusion, my studies have led us to having a greater understand of how Rad5 reverses fork DNA substrates to promote DNA damage bypass.
description: Second, Rad18 is a scaffolding protein. Little is known about the structural basis of Rad18 scaffold function, so I wanted to model the Rad18 protein. To model the Rad18 protein, I used small-angle X-ray scattering (SAXS) and mass photometry with molecular simulations to examine the structure and conformational flexibility of Rad18. I found a that Rad18 forms a complex with Rad6 in a 2:2 oligomeric state. It has been reported that Rad18 constitutively binds pol η, but its binding to Rev1 is controlled by auto-inhibition. I found that the release of this auto-inhibition is associated with the dissociation of the Rad6-Rad18 complex to free Rad18 monomers and Rad6-Rad18 dimers. In conclusion, I have generated a model of the Rad18 protein complex and given insight into the structural basis of Rad18 scaffold function. Taken together, my studies have led to a greater understanding of the non-canonical roles of E3 proteins in regulating DNA damage bypass.