cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Adverse outcome following mild traumatic brain injury Is associated with microstructure alterations at the gray and white matter boundary
Creators: name: Pankatz, Lara
name: Rojczyk, Philine
name: Seitz-Holland, Johanna
name: Bouix, Sylvain
name: Jung, Leonard B.
name: Wiegand, Tim L. T.
name: Bonke, Elena M.
name: Sollmann, Nico
name: Kaufmann, Elisabeth
name: Carrington, Holly
name: Puri, Twishi
name: Rathi, Yogesh
name: Coleman, Michael J.
name: Pasternak, Ofer
name: George, Mark S.
name: McAllister, Thomas W.
name: Zafonte, Ross
name: Stein, Murray B.
name: Marx, Christine E.
name: Shenton, Martha E.
name: Koerte, Inga K.
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: diffusion tensor imaging
subject: mild traumatic brain injury
subject: fractional anisotropy
subject: magnetic resonance imaging
subject: post-concussion symptoms
subject: cognitive impairment
subject: DDC 610 / Medicine & health

description: The gray matter/white matter (GM/WM) boundary of the brain is vulnerable to shear strain associated with mild traumatic brain injury (mTBI). It is, however, unknown whether GM/WM microstructure is associated with long-term outcomes following mTBI. The diffusion and structural MRI data of 278 participants between 18 and 65 years of age with and without military background from the Department of Defense INTRuST study were analyzed. Fractional anisotropy (FA) was extracted at the GM/WM boundary across the brain and for each lobe. Additionally, two conventional analytic approaches were used: whole-brain deep WM FA (TBSS) and whole-brain cortical thickness (FreeSurfer). ANCOVAs were applied to assess differences between the mTBI cohort (n = 147) and the comparison cohort (n = 131). Associations between imaging features and post-concussive symptom severity, and functional and cognitive impairment were investigated using partial correlations while controlling for mental health comorbidities that are particularly common among military cohorts and were present in both the mTBI and comparison group. Findings revealed significantly lower whole-brain and lobe-specific GM/WM boundary FA (p < 0.011), and deep WM FA (p = 0.001) in the mTBI cohort. Whole-brain and lobe-specific GM/WM boundary FA was significantly negatively correlated with post-concussive symptoms (p < 0.039), functional (p < 0.016), and cognitive impairment (p < 0.049). Deep WM FA was associated with functional impairment (p = 0.002). Finally, no significant difference was observed in cortical thickness, nor between cortical thickness and outcome (p > 0.05). Findings from this study suggest that microstructural alterations at the GM/WM boundary may be sensitive markers of adverse long-term outcomes following mTBI.
La censure et son utilité : le cas Internet.
Creators: name: Corriveau, Patrice.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Sociology, Criminology and Penology.

description: La presente etude vise a examiner la censure penale comme outil privilegie de l'Etat pour controler le developpement des nouvelles technologies. Ici, le cas de la pornographie sur Internet sera analyse. Une recherche qualitative axee sur l'etude du discours politique et une analyse de la jurisprudence canadienne en la matiere permettront d'evaluer les raisons qui poussent l'Etat a vouloir controler legalement la pornographie sur l'autoroute de l'information. L'ensemble des donnees revele que la censure penale, en tant que moyen de controle des corps, pourrait etre qualifiee de "reflexe penale". L'historicite de la loi canadienne sur l'obscenite a permis d'illustrer cette constation. La pour d'une recrudescence de la pornographie sur Internet, l'opinion publique et la protection des enfants legitiment cette demarche de controle penal. Finalement, l'analyse de las jurisprudence canadienne a demontre que la loi presente une certaine efficacite malgre certaines lacunes, notamment au niveau de l'identification des suspects.
The thrombopoietin receptor agonist eltrombopag inhibits human cytomegalovirus replication via iron chelation
Creators: name: Vogel, Jens-Uwe
name: Schmidt, Sophie
name: Schmidt, Daniel
name: Rothweiler, Florian
name: Koch, Benjamin
name: Baer, Patrick
name: Rabenau, Holger
name: Michel, Detlef
name: Stamminger, Thomas
name: Michaelis, Martin
name: Cinatl, Jindrich
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: Antiviral therapy
subject: Drug resistance
subject: Iron chelation
subject: Eltrombopag
subject: DDC 570 / Life sciences
subject: DDC 610 / Medicine & health
subject: Cytomegalovirus
subject: Iron chelating agents
subject: Antiviral agents; Therapeutic use
subject: Receptors, Thrombopoietin; Agonists
subject: Cytomegalie-Virus
subject: Arzneimittelresistenz

description: The thrombopoietin receptor agonist eltrombopag was successfully used against human cytomegalovirus (HCMV)-associated thrombocytopenia refractory to immunomodulatory and antiviral drugs. These effects were ascribed to the effects of eltrombopag on megakaryocytes. Here, we tested whether eltrombopag may also exert direct antiviral effects. Therapeutic eltrombopag concentrations inhibited HCMV replication in human fibroblasts and adult mesenchymal stem cells infected with six different virus strains and drug-resistant clinical isolates. Eltrombopag also synergistically increased the anti-HCMV activity of the mainstay drug ganciclovir. Time-of-addition experiments suggested that eltrombopag interfered with HCMV replication after virus entry. Eltrombopag was effective in thrombopoietin receptor-negative cells, and the addition of Fe3+ prevented the anti-HCMV effects, indicating that it inhibits HCMV replication via iron chelation. This may be of particular interest for the treatment of cytopenias after hematopoietic stem cell transplantation, as HCMV reactivation is a major reason for transplantation failure. Since therapeutic eltrombopag concentrations are effective against drug-resistant viruses, and synergistically increase the effects of ganciclovir, eltrombopag is also a drug-repurposing candidate for the treatment of therapy-refractory HCMV disease.
Design of Interactions for Handheld Augmented Reality Devices Using Wearable Smart Textiles: Findings from a User Elicitation Study
Creators: name: Nanjappan, Vijayakumar
name: Shi, Rongkai
name: Liang, Hai-Ning
name: Xiao, Haoru
name: Lau, Kim King-Tong
name: Hasan, Khalad
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Advanced developments in handheld devices’ interactive 3D graphics capabilities, processing power, and cloud computing have provided great potential for handheld augmented reality (HAR) applications, which allow users to access digital information anytime, anywhere. Nevertheless, existing interaction methods are still confined to the touch display, device camera, and built-in sensors of these handheld devices, which suffer from obtrusive interactions with AR content. Wearable fabric-based interfaces promote subtle, natural, and eyes-free interactions which are needed when performing interactions in dynamic environments. Prior studies explored the possibilities of using fabric-based wearable interfaces for head-mounted AR display (HMD) devices. The interface metaphors of HMD AR devices are inadequate for handheld AR devices as a typical HAR application require users to use only one hand to perform interactions. In this paper, we aim to investigate the use of a fabric-based wearable device as an alternative interface option for performing interactions with HAR applications. We elicited user-preferred gestures which are socially acceptable and comfortable to use for HAR devices. We also derived an interaction vocabulary of the wrist and thumb-to-index touch gestures, and present broader design guidelines for fabric-based wearable interfaces for handheld augmented reality applications.
Understanding Oriental cultures
Creators: name: Gare, Arran
Publisher: name: Swinburne
Year: 2024

description: If the arguments of Edward Said's Orientalism are valid, Joseph Needham's Science and Civilisation in China stands condemned. The opposition between Foucault, Said's main source of inspiration, and both Marxism and hermeneutics is highlighted. Utilizing the work of Maclntyre, recent hermeneutic philosophy is defended against Foucault, and through this, Needham's work is defended as a form of Marxist hermeneutics.
No gas source, no problem: proximity to pre‐existing embolism and segmentation affect embolism spreading in angiosperm xylem by gas diffusion
Creators: name: Guan, Xinyi
name: Pereira, Luciano
name: McAdam, Scott A. M.
name: Cao, Kun‐Fang
name: Jansen, Steven
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: bordered pits
subject: drought stress
subject: optical method
subject: pneumatic method
subject: vessel network
subject: DDC 580 / Botanical sciences
subject: Droughts
subject: Dürre

description: Embolism spreading in dehydrating angiosperm xylem is driven by gas movement between embolized and sap-filled conduits. Here we examine how the proximity to pre-existing embolism and hydraulic segmentation affect embolism propagation. Based on the optical method, we compare xylem embolism resistance between detached leaves and leaves attached to branches, and between intact leaves and leaves with cut minor veins, for six species. Embolism resistance of detached leaves was significantly lower than that of leaves attached to stems, except for two species, with all vessels ending in their petioles. Cutting of minor veins showed limited embolism spreading in minor veins near the cuts prior to major veins. Moreover, despite strong agreement in the overall embolism resistance of detached leaves between the optical and pneumatic method, minor differences were observed during early stages of embolism formation. We conclude that embolism resistance may represent a relative trait due to an open-xylem artefact, with embolism spreading possibly affected by the proximity and connectivity to pre-existing embolism as a gas source, while hydraulic segmentation prevents such artefact. Since embolism formation may not rely on a certain pressure difference threshold between functional and embolized conduits, we speculate that embolism is facilitated by pressure-driven gas diffusion across pit membranes.
Supplementary document for Multiplexing-oriented plasmon-MoS2 hybrid metasurfaces driven by nonlinear quasi bound states in the continuum - 5050408.pdf
Creators: name: Ren, Qun
name: Feng, Feng
name: Yao, Xiang
name: Xu, Quan
name: Lan, Zhihao
name: You, Jian Wei
name: Xiao, Xiaofei
name: Sha, Wei
name: Xin, Ming
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: methods and fabrication process
Mechanisms governing avian phylosymbiosis: genetic dissimilarity based on neutral and MHC regions exhibits little relationship with gut microbiome distributions of Galápagos mockingbirds
Creators: name: Fleischer, Ramona
name: Risely, Alice
name: Hoeck, Paquita E. A.
name: Keller, Lukas
name: Sommer, Simone
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Host–microbe interactions
subject: Wildlife genetics
subject: DDC 570 / Life sciences
subject: DDC 590 / Animals (Zoology)
subject: Biogeography
subject: Major histocompatibility complex
subject: Microsatellites (Genetics)
subject: Host Microbial Interactions
subject: Biogeografie
subject: MHC
subject: Mimus

description: The gut microbiome of animals, which serves important functions but can also contain potential pathogens, is to varying degrees under host genetic control. This can generate signals of phylosymbiosis, whereby gut microbiome composition matches host phylogenetic structure. However, the genetic mechanisms that generate phylosymbiosis and the scale at which they act remain unclear. Two non-mutually exclusive hypotheses are that phylosymbiosis is driven by immunogenetic regions such as the major histocompatibility complex (MHC) controlling microbial composition, or by spatial structuring of neutral host genetic diversity via founder effects, genetic drift, or isolation by distance. Alternatively, associations between microbes and host phylogeny may be generated by their spatial autocorrelation across landscapes, rather than the direct effects of host genetics. In this study, we collected MHC, microsatellite, and gut microbiome data from separate individuals belonging to the Galápagos mockingbird species complex, which consists of four allopatrically distributed species. We applied multiple regression with distance matrices and Bayesian inference to test for correlations between average genetic and microbiome similarity across nine islands for which all three levels of data were available. Clustering of individuals by species was strongest when measured with microsatellite markers and weakest for gut microbiome distributions, with intermediate clustering of MHC allele frequencies. We found that while correlations between island-averaged gut microbiome composition and both microsatellite and MHC dissimilarity existed across species, these relationships were greatly weakened when accounting for geographic distance. Overall, our study finds little support for large-scale control of gut microbiome composition by neutral or adaptive genetic regions across closely related bird phylogenies, although this does not preclude the possibility that host genetics shapes gut microbiome at the individual level.
Use of an administrative database to develop and test a model to predict the allocation of clinical pharmacy human resources.
Creators: name: Potvin, Kenneth A.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Health Sciences, Pharmacy.

description: Pharmacy managers are handicapped by a lack of research in the area of resource allocation and utilization as it applies to clinical pharmacy staff. Using the decision support system at a tertiary care teaching facility in Ottawa, Ontario, two statistical models were developed and validated using over 7000 cases from each of two consecutive fiscal years. Multiple logistic regression analysis was used to identify the patient-level variables that were valid predictors of who would receive clinical pharmacy services: attending physician specialty, length of stay, complexity code, drug category. The model accurately classified 81.8% of patient encounters. A multivariate linear regression analysis was undertaken to identify the predictors of the cost of clinical pharmacy services: attending physician specialty, length of stay, drug category, drug cost, other hospital costs. These elements explained 43% of the variability in the outcome. The applicability of the models for daily operations and planning is described.
Manipulation of autophagy by SARS-CoV-2 proteins
Creators: name: Köpke, Lennart
name: Hirschenberger, Maximilian
name: Hayn, Manuel
name: Kirchhoff, Frank
name: Sparrer, Konstantin
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: ORF3a
subject: ORF7a
subject: Nsp15
subject: Envelope protein
subject: Double-membrane vesicles
subject: Innate immunity
subject: DDC 570 / Life sciences
subject: DDC 610 / Medicine & health
subject: COVID-19
subject: SARS-CoV-2
subject: Autophagy
subject: Membrane proteins
subject: Angeborene Immunität
subject: Autophagie
subject: SARS-CoV-2

description: As part of innate immune defenses, macroautophagy/autophagy targets viruses and viral components for lysosomal degradation and exposes pathogen-associated molecular patterns to facilitate recognition. However, viruses evolved sophisticated strategies to antagonize autophagy and even exploit it to promote their replication. In our recent study, we systematically analyzed the impact of individual SARS-CoV-2 proteins on autophagy. We showed that E, M, ORF3a, and ORF7a cause an accumulation of autophagosomes, whereas Nsp15 prevents the efficient formation of autophagosomes. Consequently, autophagic degradation of SQSTM1/p62 is decreased in the presence of E, ORF3a, ORF7a, and Nsp15. Notably, M does not alter SQSTM1 protein levels and colocalizes with accumulations of LC3B-positive membranes not resembling vesicles. Infection with SARS-CoV-2 prevents SQSTM1 degradation and increases lipidation of LC3B, indicating overall that the infection causes a reduction of autophagic flux. Our mechanistic analyses showed that the accessory proteins ORF3a and ORF7a both block autophagic degradation but use different strategies. While ORF3a prevents the fusion between autophagosomes and lysosomes, ORF7a reduces the acidity of lysosomes. In summary, we found that Nsp15, E, M, ORF3a, and ORF7a of SARS-CoV-2 manipulate cellular autophagy, and we determined the molecular mechanisms of ORF3a and ORF7a.
Requisitos y recomendaciones para la calibración de sensores meteorológicos – EMA (Viento). Buenos Aires – AR, noviembre de 2018.
Creators: name: Santana, Márcio
Publisher: name: Zenodo
Year: 2018
Subjects: requisitos BIPM
recomendaciones WMO
calibración
anemómetro
instrumentación meteorológica

description: Requisitos y recomendaciones para la calibración de sensores meteorológicos – Estación Meteorológica (viento). Requirements and recommendations for the calibration of meteorological sensors (wind - view of the meteorological instrumentation), doi 10.5281 / zenodo 4021073.
description: "Quality Infrastructure of the Regional Fund for Biodiversity and Climate Protection in Latin America and the Caribbean" Project "Metrology for Meteorology" - https://www.ptb.de/lac/index.php?id=fund-qi-biodiversity-climate
Online alcohol interventions: a systematic review
Creators: name: White, Angela
name: Kavanagh, David
name: Stallman, Helen
name: Klein, Britt
name: Kay-Lambkin, Frances
name: Proudfoot, Judy
name: Drennan, Judy
name: Connor, Jason
name: Baker, Amanda
name: Hines, Emily
name: Young, Ross
Publisher: name: Swinburne
Year: 2024

description: Background: There has been a significant increase in the availability of online programs for alcohol problems. A systematic review of the research evidence underpinning these programs is timely. Objectives: Our objective was to review the efficacy of online interventions for alcohol misuse. Systematic searches of Medline, PsycINFO, Web of Science, and Scopus were conducted for English abstracts (excluding dissertations) published from 1998 onward. Search terms were: (1) Internet, Web*; (2) online, computer*; (3) alcohol*; and (4) Eeffect*, trial*, random* (where * denotes a wildcard). Forward and backward searches from identified papers were also conducted. Articles were included if (1) the primary intervention was delivered and accessed via the Internet, (2) the intervention focused on moderating or stopping alcohol consumption, and (3) the study was a randomized controlled trial of an alcohol-related screen, assessment, or intervention. Results: The literature search initially yielded 31 randomized controlled trials (RCTs), 17 of which met inclusion criteria. Of these 17 studies, 12 (70.6%) were conducted with university students, and 11 (64.7%) specifically focused on at-risk, heavy, or binge drinkers. Sample sizes ranged from 40 to 3216 (median 261), with 12 (70.6%) studies predominantly involving brief personalized feedback interventions. Using published data, effect sizes could be extracted from 8 of the 17 studies. In relation to alcohol units per week or month and based on 5 RCTs where a measure of alcohol units per week or month could be extracted, differential effect sizes to posttreatment ranged from 0.02 to 0.81 (mean 0.42, median 0.54). Pre-post effect sizes for brief personalized feedback interventions ranged from 0.02 to 0.81, and in 2 multi-session modularized interventions, a pre-post effect size of 0.56 was obtained in both. Pre-post differential effect sizes for peak blood alcohol concentrations (BAC) ranged from 0.22 to 0.88, with a mean effect size of 0.66. Conclusions: The available evidence suggests that users can benefit from online alcohol interventions and that this approach could be particularly useful for groups less likely to access traditional alcohol-related services, such as women, young people, and at-risk users. However, caution should be exercised given the limited number of studies allowing extraction of effect sizes, the heterogeneity of outcome measures and follow-up periods, and the large proportion of student-based studies. More extensive RCTs in community samples are required to better understand the efficacy of specific online alcohol approaches, program dosage, the additive effect of telephone or face-to-face interventions, and effective strategies for their dissemination and marketing.
Improving birth outcomes for women who are substance using or have mental illness: a Canadian cohort study comparing antenatal midwifery and physician models of care for women of low socioeconomic position
Creators: name: McRae, Daphne N.
name: Muhajarine, Nazeem
name: Janssen, Patricia A.
Publisher: name: BioMed Central
Year: 2019

description: Background: Some observational studies have shown improved birth outcomes for women of low socioeconomic position (SEP) receiving antenatal midwifery versus physician care. To understand for whom and under what circumstances midwifery care is associated with better birth outcomes we examined whether psychosocial risk including substance use, mental illness, social assistance, residence in a neighbourhood of low/moderate SEP, and teen maternal age modified the association between model of care (midwifery versus physician) and small-for-gestational-age (SGA) or preterm birth (PTB) for women of low SEP. Methods: For this retrospective cohort study, maternity data from the British Columbia Perinatal Data Registry were linked with Medical Services Plan billing data. We report adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for SGA birth (< the 10th percentile) and PTB (< 37 weeks’ completed gestation). For tests of interaction between antenatal models of care and psychosocial risk, p-values < 0.10 were considered statistically significant. Women were eligible for inclusion if they were residents of British Columbia, Canada, carried a singleton fetus, had low to moderate medical/obstetric risk, birthed between April 1, 2008 and Dec. 31, 2012, and received a health insurance subsidy (n = 33,937). Results: Midwifery versus obstetrician patients had lower odds of PTB. The difference was 31% larger among substance users (aOR 0.24, 95% CI: 0.11–0.54) compared to non-substance users (aOR 0.55, 95% CI: 0.45–0.68). Additionally, there was a 34% statistically significant absolute difference in odds of PTB for midwifery versus obstetrician patients with both mental illness and substance use (aOR 0.18, 95% CI: 0.06–0.55) compared to women with neither mental illness nor substance use (aOR 0.52, 95% CI: 0.41–.66). Results demonstrated a consistent association between midwifery versus physician care and lower odds of SGA, yet effects were not statistically significantly different for women with higher or lower psychosocial risk. Conclusion: Among low SEP women in British Columbia, Canada, antenatal midwifery compared to obstetrician care was associated with reduced odds of PTB. Odds were lower among women with substance use, and mental illness and substance use, than among women without these risk factors.
Lärmminderung durch Bürgerbeteiligung
Creators: name: Elsässer, Ralf
name: Mothes, Fritjof
Publisher: name: My University
Year: 2013
Subjects: subject: Lärmminderungsplanung
subject: Lärmaktionsplanung
subject: Bürgerbeteiligung
subject: Lärm
subject: Transport

description: Das Projekt „Mach’s leiser – Mitwirken bei der Lärmaktionsplanung in Leipzig“ wurde initiiert, um am Beispiel von sieben Ortsteilen im Leipziger Norden ein Mitwirkungsverfahren im Rahmen der Lärmaktionsplanung zu erproben, welches im Gegensatz zur formalen Lärmaktionsplanung und vielen bisher gelaufenen Verfahren in anderen Städten einen Bottom-Up-Ansatz verfolgt. Das Kernelement bildete dabei die Durchführung eines Workshopverfahrens in Anlehnung an die Methode der Planungszelle. Hierfür wurden aus der Wohnbevölkerung des Projektgebietes in Form einer Zufallsauswahl ca. 100 Personen zur Mitwirkung eingeladen.
The lower main sequence and mass function of the globular cluster Messier 4
Creators: name: Richer, Harvey B.
name: Brewer, James
name: Fahlman, Gregory G.
name: Gibson, Brad K.
name: Hansen, Brad M.
name: Ibata, Rodrigo A.
name: Kalirai, Jasonjot S.
name: Limongi, Marco
name: Rich, R. Michael
name: Saviane, Ivo
name: Shara, Michael M.
name: Stetson, Peter B.
Publisher: name: Swinburne
Year: 2024

description: The deepest optical image ever in a globular star cluster, a Hubble Space Telescope (HST) 123 orbit exposure in a single field of Messier 4, was obtained in 2 filters (F606W, F814W) over a 10 week period in early 2001. A somewhat shallower image obtained in 1995 allowed us to select out cluster and field objects via their proper motion displacement resulting in remarkably clean color-magnitude diagrams that reach to V = 30, I = 28. The cluster main sequence luminosity function contains very few stars fainter than MV = 15.0, MI = 11.8 which, in both filters, is more than 2 magnitudes brighter than our limit. This is about the faintest luminosity seen among field Population II subdwarfs of the same metallicity. However, there remains a sprinkling of potential cluster stars to lower luminosity all the way down to our limiting magnitudes. These latter objects are significantly redder than any known metal-poor field subdwarf. Comparison with the current generation of theoretical stellar models implies that the masses of the lowest luminosity cluster stars observed are near 0.09 Msun. We derive the mass function of the cluster in our field and find that it is very slowly rising towards the lowest masses with no convincing evidence of a turnover even below 0.1 Msun. The formal slope between 0.65 and 0.09 Msun is alpha = 0.75 (Salpeter of 2.35) with a 99% confidence interval 0.55 - 1.05. A consistency check between these slopes and the number of observed cluster white dwarfs yields a range of possible conclusions, one of which is that we have indeed seen the termination of the white dwarf cooling sequence in M4.
Canadian women sprint racing canoeists' retirement from the National Team.
Creators: name: McGown, Elizabeth.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Women's Studies.

description: Through extracting accurate formalized versions of the subject's actions, motive, and experiences to describe and explain their retirement phenomenon, this study attempted to capture the substance and nuance of the opinions of women athletes now retired who competed in the Olympic canoeing discipline of sprint racing as members of the Canadian National Canoe Team between 1984 to 1998. Whether smooth or problematic, retirement necessitates a degree of adjustment which is thought to be dependent on the individual's perception of retirement itself. In this regard, the qualitative methodology, borrowing from phenomenology and free from predetermined theories, concentrated on the subject-experience and assumed the importance of understanding the retirement experience, as it is known to, and in the words of the women who lived the experience. In addition, the choice of focusing on only one National Team permitted a fuller contextualization of the retirement phenomenon within a specific sport environment. A short demographic questionnaire was initially given to the study participants to ascertain basic information. This was followed by an open-ended in-depth interview, using a semi-structured format, to obtain information pertaining to the specific reasons and circumstances affecting their retirement, as well as the manner in which they reacted to, and deal with their retirement from the National Canoe Team. Data collection and analysis were undertaken simultaneously which ensured a systematic effort to verify and refine existing themes. Data were submitted to a systematic process which enabled the reduction of the vast quantity of data into manageable segments. Coding of the data served to separate, compile, and organize the data, while comparing the events, experiences, actions, and interactions for similarities and differences. Through content analysis, both inference and interpretation were used to give meaning to the transcripts. The end result was the emergence of themes from the data, each theme internally consistent but distinct and separate from all other themes identified. The inductive examination of the relationships present within and among the identified themes allowed for developing interpretations and explanations of the phenomenon under study. In an effort to capture and understand the essence of the retirement experience, a schematic representation was drawn which encapsulates the major patterns found in the women's narratives regarding their retirement experiences. The patterns are located on a continuum which reflects the inter-relationships of the experiences and reactions. (Abstract shortened by UMI.)
Web-based feedback on conceptual understanding of physics for science and engineering first year students
Creators: name: Mazzolini, Alexander
name: Mazzolini, Margaret M.
name: Rachinger, William A.
name: Moss, Barbara K.
name: Humble, John E.
Publisher: name: Swinburne
Year: 2024

description: A good grounding in introductory physics is essential in many science and engineering courses. Many of the students coming into these courses do not have a physics background, and those that do often have poor understanding because of incorrect physics preconceptions. Traditional teaching methods may do little to promote good physics learning or change misconceptions for many of these students. Testing Conceptual Understanding in Physics (TCUP) is funded by the Committee for University Teaching and Staff Development, and is a project that aims to provide timely feedback on the conceptual understanding of students studying first-year physics. The approach is to provide automatic assessment via an easy to operate browser-based computer managed testing system. To promote effective learning, individual students will receive formative feedback regarding their level of conceptual understanding in each key area of physics covered in their particular course. Statistical information will also be available to the instructor to help assess the performance of the class in each of these key areas.
Clinical pharmacokinetics and pharmacodynamics of roxadustat
Creators: name: Czock, David
name: Keller, Frieder
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: DDC 610 / Medicine & health
subject: Pharmacodynamics
subject: Pharmacokinetics
subject: Pharmakokinetik

description: The pharmacokinetics of roxadustat are well characterized, with an apparent volume of distribution after oral administration of 22–57 L, apparent clearance of 1.2–2.65 L/h, and renal clearance of 0.030–0.026 L/h in healthy volunteers; the elimination half-life is 9.6–16 h. Plasma binding is 99% and the fraction eliminated by hemodialysis is 2.34%. As an interpretation of the pharmacodynamics of roxadustat, we proposed a concept with a hypothetical cascade of two subsequent effects, first on erythropoetin (EPO) and second on hemoglobin (delta Hb). The primary effect on EPO is observed within a few hours after roxadustat administration and can be modeled using the sigmoidal Hill equation. The concentration at half-maximum effect can be inferred at 10–36 µg/mL, the Hill coefficient at 3.3, and the effect bisection time at 10–17 h, corresponding to EPO half-life. The subsequent effect on hemoglobin (delta Hb) is observed after several weeks and can be interpreted as an irreversible, dose proportional, unsaturable effect, continuing in agreement with the lifespan of red blood cells of 63–112 days.
Evaluation of polydentate picolinic acid chelating ligands and an α-melanocyte-stimulating hormone derivative for targeted alpha therapy using ISOL-produced 225Ac
Creators: name: Ramogida, Caterina F
name: Robertson, Andrew K H
name: Jermilova, Una
name: Zhang, Chengcheng
name: Yang, Hua
name: Kunz, Peter
name: Lassen, Jens
name: Bratanovic, Ivica
name: Brown, Victoria
name: Southcott, Lily
name: Rodríguez-Rodríguez, Cristina
name: Radchenko, Valery
name: Bénard, François
name: Orvig, Chris
name: Schaffer, Paul
Publisher: name: Springer International Publishing
Year: 2019

description: Background: Actinium-225 (²²⁵Ac, t₁/₂ = 9.9 d) is a promising candidate radionuclide for use in targeted alpha therapy (TAT), though the currently limited global supply has hindered the development of a suitable Ac-chelating ligand and ²²⁵Ac-radiopharmaceuticals towards the clinic. We at TRIUMF have leveraged our Isotope Separation On-Line (ISOL) facility to produce ²²⁵Ac and use the resulting radioactivity to screen a number of potential ²²⁵Ac-radiopharmaceutical compounds. Results: MBq quantities of ²²⁵Ac and parent radium-225 (²²⁵Ra, t₁/₂ = 14.8 d) were produced and separated using solid phase extraction DGA resin, resulting in a radiochemically pure ²²⁵Ac product in > 98% yield and in an amenable form for radiolabeling of ligands and bioconjugates. Of the many polydentate picolinic acid (“pa”) containing ligands evaluated (H₄octapa [N₄O₄], H₄CHXoctapa [N₄O₄], p-NO₂-Bn-H₄neunpa [N₅O₄], and H₆phospa [N₄O₄]), all out-performed the current gold standard, DOTA for ²²⁵Ac radiolabeling ability at ambient temperature. Moreover, a melanocortin 1 receptor-targeting peptide conjugate, DOTA-modified cyclized α-melanocyte-stimulating hormone (DOTA-CycMSH), was radiolabeled with ²²⁵Ac and proof-of-principle biodistribution studies using B16F10 tumour-bearing mice were conducted. At 2 h post-injection, tumour-to-blood ratios of 20.4 ± 3.4 and 4.8 ± 2.4 were obtained for the non-blocking (molar activity [M.A.] > 200 kBq/nmol) and blocking (M.A. = 1.6 kBq/nmol) experiment, respectively. Conclusion: TRIUMF’s ISOL facility is able to provide ²²⁵Ac suitable for preclinical screening of radiopharmaceutical compounds; [²²⁵Ac(octapa)]−, [²²⁵Ac(CHXoctapa)]−, and [²²⁵Ac(DOTA-CycMSH)] may be good candidates for further targeted alpha therapy studies.
Buffeting analysis of cable-stayed bridges during their erection.
Creators: name: Huang, Zhong Ying.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Engineering, Civil.

description: Buffeting response of cable-stayed bridges at their erection stage under yawed wind has attracted engineering attention through wind tunnel observations and studies. Cable-stayed bridges are particularly vulnerable to dynamic wind effects during their construction stages due to the lack of overall structural stiffness. The most critical stage is just before the bridge main span is closed. At this time, a cable-stayed bridge resembles a long cantilever structure supported by cables, and particularly, the fundamental frequency horizontal modes of oscillation may be very low. During this stage, the cable-stayed ridge is more responsive to wind action both in lateral and vertical bending. For this reason, the prediction of wind-induced bridge response becomes more important when directional variation of wind is considered. However, only a few theoretical approaches have been proposed, applicable only in extremely simplified cases. This thesis deals with the prediction of buffeting response of cable-stayed bridges under yawed winds using the modified buffeting analysis. The modified buffeting analysis was originally developed by Kimura (1991) and was restricted to vertical bending response. The comparison with experimental data was also conducted for extremely simplified flat plate models. In this thesis, the modified buffeting approach is not only applied to actual cable-stayed bridge models but also the calculation of the lateral bending oscillation has been attempted. Further, the calculated results are compared with the experimental data obtained from the wind tunnel tests of the aeroelastic cable-stayed bridge models; the Normandy Bridge and the Kao Ping Hsi Bridge.
title: The NORMAN Association and the European Partnership for Chemicals Risk Assessment (PARC): let's cooperate!
title: The NORMAN Association and the European Partnership for Chemicals Risk Assessment (PARC): let's cooperate!
titleType: AlternativeTitle
Creators: name: Dulio, Valeria
name: Koschorreck, Jan
name: Bavel, Bert Van
name: Von Der Ohe, Peter C.
Publisher: name: My University
Year: 2020
Subjects: Umweltmonitoring

description: The Partnership for Chemicals Risk Assessment (PARC) is currently under development as a joint research and innovation programme to strengthen the scientific basis for chemical risk assessment in the EU. The plan is to bring chemical risk assessors and managers together with scientists to accelerate method development and the production of necessary data and knowledge, and to facilitate the transition to next-generation evidence-based risk assessment, a non-toxic environment and the European Green Deal. The NORMAN Network is an independent, well-established and competent network of more than 80 organisations in the field of emerging substances and has enormous potential to contribute to the implementation of the PARC partnership. NORMAN stands ready to provide expert advice to PARC, drawing on its long experience in the development, harmonisation and testing of advanced tools in relation to chemicals of emerging concern and in support of a European Early Warning System to unravel the risks of contaminants of emerging concern (CECs) and close the gap between research and innovation and regulatory processes. In this commentary we highlight the tools developed by NORMAN that we consider most relevant to supporting the PARC initiative: (i) joint data space and cutting-edge research tools for risk assessment of contaminants of emerging concern; (ii) collaborative European framework to improve data quality and comparability; (iii) advanced data analysis tools for a European early warning system and (iv) support to national and European chemical risk assessment thanks to harnessing, combining and sharing evidence and expertise on CECs. By combining the extensive knowledge and experience of the NORMAN network with the financial and policy-related strengths of the PARC initiative, a large step towards the goal of a non-toxic environment can be taken. © The Author(s) 2020
Supplementary document for Human serum albumin gradient in serous ovarian cancer cryosections measured by fluorescence lifetime - 5051046.pdf
Creators: name: LIN, FANGRUI
name: Zhang, Chenshuang
name: li, yanping
name: Yan, Junshuai
name: Xu, Yunjian
name: Pan, Ying
name: Hu, Rui
name: Liu, Liwei
name: Qu, Junle
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Absorption and fluorescence response of SD to HSA
The Crown as fiduciary and the conflict of interest inherent in its use of Indian lands for public purposes.
Creators: name: Salembier, John Paul.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Canadian Studies.

description: This thesis examines the fiduciary relationship between the federal Crown and Indian bands arising under the Indian Act, and more particularly the obligations adhering to the Crown when it accepts surrenders of reserve lands for its own purposes. It begins with an analysis of the theoretical basis of the fiduciary relationship in private law, concluding that such a relationship arises whenever a person acquires a power or property subject to the condition that the power will be exercised, or the property used, to further the interests of another. The thesis then examines the source of the Crown/Indian fiduciary relationship, and concludes that the Indian Act requirement that a band contemplating an alienation of its lands must first transfer those lands to the Crown, and the corresponding discretion vested in the Crown in disposing of those lands on the band's behalf, supply the requisite conditions, in accordance with private law fiduciary principles, for establishment of an ongoing fiduciary relationship in respect of the alienation of Indian lands. The thesis then provides a detailed review of the rules applicable to conflict of interest by a fiduciary in private law, and concludes that the more stringent requirements applicable to conflict of interest by a fiduciary in private law should also be extended to the Crown where the Crown accepts surrenders of land, or deals with Indian assets, in a manner that ultimately benefits the Crown.
Private rental trends and homelessness
Creators: name: Burke, Terry
Publisher: name: Swinburne
Year: 2024

description: The relationship between the private rental sector and homelessness is immediate and complex. Among those seeking SAAP support the private rental sector among mainstream housing tenures (ownership, purchasing and public rental) accounted for the largest proportion of the homeless presenting for support and it is also the most common exit point for people leaving SAAP services. (AIHW 1997). Thus what happens in the private rental sector is fundamental to the future form and degree of homelessness. If the rental sector becomes increasingly difficult for low income households, in terms of access and affordability, then it is potentially a context for greater homelessness. Conversely if access and affordability improve some of the pressures on homelessness will be removed.
FIGSHARE-PROTOCOL OF A SYSTEMATIC REVIEW.docx
Creators: name: Chambergo-Michilot, Diego
name: Tauma-Arrué, Astrid
name: Loli-Guevara, Silvana
Publisher: name: figshare
Year: 2020
Subjects: subject: 110201 Cardiology (incl. Cardiovascular Diseases)
subject: FOS: Clinical medicine

description: We are uploading the protocol of a systematic review entitled: "Effectiveness and safety of sodium–glucose cotransporter 2 inhibitors in patients with heart failure: a systematic review and meta-analysis".
The putative type III secreted chlamydia abortus virulence-associated protein CAB063 targets lamin and induces apoptosis
Creators: name: Marschall, Miriam Theresia
name: Simnacher, Ulrike
name: Walther, Paul
name: Essig, Andreas
name: Hagemann, Jürgen Benjamin
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Chlamydia abortus
subject: CAB063
subject: lamin
subject: DDC 570 / Life sciences
subject: Membranes (Biology)
subject: Chlamydia infections
subject: Lamins
subject: Virulence
subject: Chlamydienkrankheit
subject: Chlamydia trachomatis
subject: Apoptosis
subject: Lamine

description: Since intracellular survival of all chlamydiae depends on the manipulation of the host cell through type III secreted effector proteins, their characterization is crucial for the understanding of chlamydial pathogenesis. We functionally characterized the putative type III secreted Chlamydia abortus protein CAB063, describe its intracellular localization and identified pro- and eukaryotic binding partners. Based on an experimental infection model and plasmid transfections, we investigated the subcellular localization of CAB063 by immunofluorescence microscopy, immunoelectron microscopy, and Western blot analysis. Pro- and eukaryotic targets were identified by co-immunofluorescence, coimmunoprecipitation, and mass spectrometry. Transmission electron microscopy and flow cytometry were used for morphological and functional investigations on host cell apoptosis. CAB063 localized in the nuclear membrane of the host cell nucleus and we identified the chaperone HSP70 and lamin A/C as pro- and eukaryotic targets, respectively. CAB063-dependent morphological alterations of the host cell nucleus correlated with increased apoptosis rates of infected and CAB063-transfected cells. We provide evidence that CAB063 is a chaperone-folded type III secreted C. abortus virulence factor that targets lamin thereby altering the host cell nuclear membrane structure. This process may be responsible for an increased apoptosis rate at the end of the chlamydial developmental cycle, at which CAB063 is physiologically expressed.
Policy-based encryption and its application in a hospital system
Creators: name: Garson, Kathryn
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Computer Science.

description: Hospitals are now using electronic medical records and computer applications in order to provide more efficient and thorough care for their patients. The Mobile Emergency Triage system provides doctors with decision support for emergency care by pulling information from a patient's health record and a medical literature database. In order to achieve compliance with privacy legislations PIPEDA and PHIPA, security and privacy measures must be put in place. A new encryption technology called policy-based encryption proves to be quite useful within a health care environment for providing both encryption and access control. We describe a current policy-based encryption system to be used by MET-A3Support---a multi-agent clinical decision support system. We offer a Java implementation of the policy-based encryption algorithms. We also give details about how this system will be integrated with MET-A 3Support to protect the privacy of patient health information.
kiz Jahresbericht 2007
Creators: name: (:Unkn) Unknown
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: Jahresbericht
subject: kiz
subject: DDC 020 / Library & information sciences
subject: Universities; Germany; Ulm
subject: Kommunikations- und Informationszentrum
subject: Universität Ulm

description: Jahresbericht 2007 des Kommunikations- und Informationszentrums (kiz)
The role of hydraulic 'dead zones' in the development of phytoplankton in the Rideau River, Ontario.
Creators: name: Preece, Jennifer.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Biology, Limnology.

description: Biomass of phytoplankton in large rivers may be maintained or even increased by inputs from hydraulic "dead zones". In some eutrophic rivers, dead zones can increase water retention time sufficiently for the development of algal concentrations substantially higher than in the main channel. "Seeding" of the main channel may then occur through the interchange of water between dead zones and the main channel. The objective of this thesis was to investigate the role of dead zones in the development of phytoplankton along the moderately eutrophic Rideau River. In the first chapter, I compare the suspended algal communities in dead zones and the adjacent main channel of the Rideau, to evaluate the assumption that dead zones support higher phytoplankton biomass. In the second chapter, I test the assumption that dead zones contribute algal biomass to the main channel of rivers. To do this, I examine the relationship between changes in main channel total chlorophyll a and the proportion of dead zone (inferred from the area of shallow macrophyte-dominated water) in 40 reaches along the Rideau, averaging approximately 2 km each. (Abstract shortened by UMI.)
Supplementary document for Measurement and control of optical nonlinearities in dispersive dielectric multilayers - 5051811.pdf
Creators: name: Gui, Guan
name: Adak, Amitava
name: Dandapat, Manika
name: Carlson, Daniel
name: Morrill, Drew
name: Guggenmos, Alexander
name: Kapteyn, Henry
name: Murnane, Margaret
name: Pervak, Vladimir
name: Liao, Chen-Ting
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary figures Fig S1-S8