cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Lesson Study sur les outils médiateurs pour la résolution de problèmes mathématiques additifs et soustractifs en quatrième et cinquième primaire.
title: Lesson Study sur les outils médiateurs pour la résolution de problèmes mathématiques additifs et soustractifs en quatrième et cinquième primaire.
titleType: AlternativeTitle
Creators: name: Poulet, Roxanne
name: Pfister, Gaël
Publisher: name: Unknown
Year: 0
Subjects: subject: Lesson Study
subject: outils médiateurs
subject: résolution de problèmes
subject: enseignement primaire
subject: mathématiques
subject: difficultés d’apprentissage

description: Dans ce mémoire, nous abordons la thématique de la résolution de problèmes en mathématiques, que ce soit des problèmes additifs ou soustractifs. En nous focalisant sur les élèves dans un premier temps, nous repérons les outils médiateurs que ces derniers utilisent lors de la résolution de problèmes mathématiques, et plus précisément lors de problèmes additifs et soustractifs. Nous avons mis en place une Lesson Study visant à répondre à notre question de recherche : comment faire évoluer l’apprentissage et l’utilisation des outils médiateurs des élèves de quatrième et cinquième primaire dans la résolution de problèmes additifs et soustractifs en mathématiques ? Le but de cette leçon de recherche a été de trouver les bons outils médiateurs à enseigner au bon moment et d’utiliser les déjà-là des élèves, ceci afin de les renforcer, mais aussi de pouvoir enseigner efficacement les mathématiques et plus précisément lors de résolution de problèmes additifs et soustractifs. En outre, l’objectif est que tous les élèves puissent atteindre leurs objectifs d’apprentissages. À partir de cette recherche, nous avons pu éprouver une méthode efficace pour aborder des situations-problèmes de manière structurée pour les élèves.
Solution pour améliorer la maintenance des ponts
Creators: name: Dao, Duy Lam
name: Nguyen, Viet Trung
name: Nguyen, Quang Huy
Publisher: name: Academic Journal of Civil Engineering
Year: 2019

description: BHMS (Système de surveillance des ponts) est un nouvel outil efficace pour surveiller et évaluer les états des structures régulièrement et en permanence qui comprend des outils de diagnostic pour les structures de pont, combiné avec des équipements de surveillance météorologique et de surveillance du trafic pour collecter un grand volume de résultat pour l'état actuel, à analyser des informations significatives pour la maintenance des ponts. Bien que le domaine de BHMS soit toujours difficile dans le monde entier, les systèmes de réalité BHMS ont été installés dans plusieurs ponts à haubans principaux (maintenant disponibles dans plus de 10 ponts) au Vietnam avec des problèmes remarquables. Cet article aide à évaluer la situation actuelle au Vietnam et montre les solutions pour résoudre ces problèmes et améliorer l'efficacité de l'utilisation de BHMS dans les travaux de maintenance pour la durabilité et la longévité de pont.
description: Academic Journal of Civil Engineering, Vol 36 No 1 (2018): Special Issue - RUGC 2018 St Etienne
Neural Control Variates with Automatic Integration
Creators: name: Li, Zilu
name: Yang, Guandao
name: Zhao, Qingqing
name: Deng, Xi
name: Guibas, Leonidas
name: Hariharan, Bharath
name: Wetzstein, Gordon
Publisher: name: arXiv
Year: 2024
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: Graphics (cs.GR)
subject: Numerical Analysis (math.NA)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: This paper presents a method to leverage arbitrary neural network architecture for control variates. Control variates are crucial in reducing the variance of Monte Carlo integration, but they hinge on finding a function that both correlates with the integrand and has a known analytical integral. Traditional approaches rely on heuristics to choose this function, which might not be expressive enough to correlate well with the integrand. Recent research alleviates this issue by modeling the integrands with a learnable parametric model, such as a neural network. However, the challenge remains in creating an expressive parametric model with a known analytical integral. This paper proposes a novel approach to construct learnable parametric control variates functions from arbitrary neural network architectures. Instead of using a network to approximate the integrand directly, we employ the network to approximate the anti-derivative of the integrand. This allows us to use automatic differentiation to create a function whose integration can be constructed by the antiderivative network. We apply our method to solve partial differential equations using the Walk-on-sphere algorithm. Our results indicate that this approach is unbiased and uses various network architectures to achieve lower variance than other control variate methods.
Da (in)validade do AO'90 no Ordenamento Jurídico Português
Creators: name: Figueiredo, Alexandre M. Pereira
Publisher: name: artciencia.com, Revista de Arte, Ciência e Comunicação
Year: 2021

description: A presente reflexão tem por objectivo a clarificação da norma ortográfica legalmente vigente na ordem jurídica portuguesa. Tal exercício decorre da grave incerteza presentemente existente na sociedade nacional em torno da norma ortográfica efectivamente vigorante devido à adopção, por parte do Governo e, concomitantemente, da generalidade dos organismos inseridos na Administração Pública das regras ortográficas emanadas do Acordo Ortográfico da Língua Portuguesa, assinado em Lisboa, em 1990.
description: artciencia.com, Revista de Arte, Ciência e Comunicação, N.º 24-25 (2021): Ano XII - Dezembro 2019 - Julho 2021
Solutions constructives hybrides structurales pour des applications planchers et façades de bâtiments neufs
Creators: name: Titirla, Magdalini
name: Michel, Laurent
name: Ferrier, Emmanuel
Publisher: name: Academic Journal of Civil Engineering
Year: 2019

description: Cet article présente une étude expérimentale de connexions innovantes entre des planchers hybrides et des colonnes en bois. Chaque panneau est composé de poutres en bois lamellé collé et/ou de béton constituant les planchers et de poutres en bois constituant l’ossature porteuse des éléments de façade. Cinq spécimens, impliquant cinq types de différentes connexions, soumis à une flexion monotone croissante, sont examinés. Le premier type de connexion incorpore une colonne de type goujon qui se joint à la poutre à travers de longs boulons, tandis que le second consiste à mettre en place une platine métallique incorporée dans les poutres en bois fendues des planchers et des colonnes, l’ensemble étant relié par l’intermédiaire de boulons transversaux. Les trois autres types de connexion sont éloignés des connexions boulonnées habituelles, car le troisième type de connexion incorpore une barre d'armature métallique dans un « nœud » réalisé en BFUP, tandis que le quatrième consiste à disposer des barres FRP en carbone dans la partie bois et béton des poutres par collage, et le cinquième consiste à disposer des barres FRP en verre dans la partie bois et béton des poutres par collage. Les séquences expérimentales sont menées dans les locaux de Laboratoire de Matériaux Composites et Structures Composites de l'Université Claude Bernard Lyon 1.
description: Academic Journal of Civil Engineering, Vol 36 No 1 (2018): Special Issue - RUGC 2018 St Etienne
Effects of the gut-liver axis on the liver lipid metabolism of aged laying hens fed with low-protein diets
Creators: name: 潘洪彬
Publisher: name: CNGB
Year: 2023
Subjects: Raw sequence reads
Multispecies
Agricultural

description: This study combines multiple omics techniques (transcriptomics, 16s, and metabolomics) to comprehensively analyze the impact of low protein diets on liver lipid metabolism in laying hens through the gut liver axis, providing scientific basis for precise regulation of low protein diets.
Développement d’une méthodologie de diagnostic énergétique dérivée de l’outil réglementaire
Creators: name: Amiel, Martin
name: Sauce, Gérard
name: Buhe, Catherine
name: Boileau, Hervé
Publisher: name: Academic Journal of Civil Engineering
Year: 2019

description: Les auteurs s’intéressent au diagnostic de bâtiments existants afin d’identifier la meilleure solution de réhabilitation pour au final mettre en place un Contrat de Performance Energétique, cela dans le contexte spécifique des bâtiments ’habitation saisonniers en montagne. Ils mettent en évidence les insuffisances des outils actuels, essentiellement tournés vers le respect des obligations réglementaires, à savoir une estimation des consommations d’énergie et des émissions de gaz à effet de serre permettant l’information et la sensibilisation de l’acquéreur. Partant de l’outil 3CL-DPE, cette communication présente une analyse critique de cette approche sur les points suivants : les consommations d’énergies liées au chauffage et l’eau chaude sanitaire (ECS). Elle développe les améliorations proposées : une discrétisation mensuelle des calculs, une meilleure prise en compte de l’environnement extérieur, des modes de calcul du chauffage, de l’ECS et la création de modules de calcul permettant de prendre en compte les consommations liées à l’usage spécifique de l’électricité et des auxiliaires. Le tout permettant d’atteindre les objectifs d’établir un diagnostic réel du comportement du bâtiment.
description: Academic Journal of Civil Engineering, Vol 36 No 1 (2018): Special Issue - RUGC 2018 St Etienne
L’effet d’incertitude du comportement des occupants et des matériaux de l'enveloppe du bâtiment sur les besoins énergétiques
Creators: name: Belazi, Walid
name: Ouldboukhitine, Salah-Eddine
name: Chateauneuf, Alaa
name: Bouchair, Hamid
Publisher: name: Academic Journal of Civil Engineering
Year: 2019

description: Dans cet article, un modèle numérique est développé pour analyser l'incertitude du comportement des occupants et des matériaux de l'enveloppe du bâtiment sur la performance énergétique. Des variations aléatoires des paramètres liés au comportement des occupants et à l'enveloppe du bâtiment sont étudiées afin de quantifier les incertitudes sur les demandes énergétiques finales. En ce qui concerne le comportement des occupants, les paramètres étudiés sont les heures d'arrivée et de départ des occupants, le nombre d'occupants et les gains internes attribuables aux activités des occupants. En ce qui concerne l'enveloppe du bâtiment, les paramètres étudiés sont les valeurs U des murs extérieurs, du sol et du toit. Les résultats montrent une grande variation des besoins énergétiques en raison des incertitudes liées au comportement des occupants et aux propriétés physiques des matériaux de construction. Les incertitudes dans les données d'entrée montrent que les paramètres liés au comportement des occupants ont une influence considérable dans les climats chauds par rapport aux paramètres liés aux matériaux de l'enveloppe du bâtiment. En revanche, pour le climat froid, l'influence est plus marquée pour les paramètres liés à l'enveloppe du bâtiment que les paramètres liés au comportement des occupants.
description: Academic Journal of Civil Engineering, Vol 36 No 1 (2018): Special Issue - RUGC 2018 St Etienne
Low temperature synthesis of BiFeO$_{3}$ nanoparticles with enhanced magnetization and promising photocatalytic performance in dye degradation and hydrogen evolution
Creators: name: Basith, M. A.
name: Yesmin, Nilufar
name: Hossain, Rana
Publisher: name: arXiv
Year: 2022
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: In this investigation, we have synthesized BiFeO$_{3}$ nanoparticles by varying hydrothermal reaction temperatures from 200 $^{\circ}$C to 120 $^{\circ}$C to assess their visible-light-driven photocatalytic activity along with their applicability for hydrogen production via water splitting. The rhombohedral perovskite structure of BiFeO$_{3}$ is formed for hydrothermal reaction temperature up to 160 $^{\circ}$C, however, for a further decrement of reaction temperature a mixed sillenite phase is observed. The XRD Rietveld analysis, XPS analysis and FESEM imaging ensure the formation of single-phase and well crystalline nanoparticles at 160 $^{\circ}$C reaction temperature with 20 nm of average size. The nanoparticles fabricated at this particular reaction temperature also exhibit improved magnetization, reduced leakage current density and excellent ferroelectric behavior. These nanoparticles demonstrate considerably high absorbance in the visible range with a low bandgap (2.1 eV). The experimentally observed bandgap is in excellent agreement with the calculated bandgap using the first-principles calculations. The favorable photocatalytic performance of these nanoparticles has been able to generate more than two times of solar hydrogen compared to that produced by bulk BiFeO$_{3}$ as well as commercially available Degussa P25 titania. Notably, the experimentally observed bandgap is almost equal for both bulk material and nanoparticles prepared at different reaction temperatures. Therefore, in solar energy applications, the superiority of BFO nanoparticles prepared at 160 $^{\circ}$C reaction temperature may be attributed not only to solely their bandgap but also to other factors, such as reduced particle size, excellent morphology, well crystallinity, large surface to volume ratio, ferroelectricity and so on.
description: 17 pages, 8 figures, 2 tables
Da Pré-Consciência da Importância da Língua Portuguesa e do seu Louvor em Tempos de Dom´inio Filipino na Arte Poética de D. António de Ataíde
Creators: name: Cordeiro, Adriano Milho
Publisher: name: artciencia.com, Revista de Arte, Ciência e Comunicação
Year: 2021

description: Resumo António de Ataíde, 5.º conde da Castanheira e 1.º conde de Castro D’Aire, nasceu por volta de 1567 ou um pouco antes e morreu a 14 de Dezembro de 1647. Vivenciou os impactos da sua existência com índole apaixonada e os limiares de novas conceções artísticas e literárias como homem de letras singular, insigne capitão-general do ponto de vista da estratégia militar, almirante versado e político polifacetado nas suas práticas. Presenciou as primeiras colonizações do Brasil, experimentou o desastre de Alcácer‑Quibir e a subsequente perda da independência; escolheu o partido dos Filipes – sem nunca descurar a sua origem lusa –, governou regiões desmedidas, ambulou pela Índia, deslizou por oceanos e sentiu na pele as fragosidades dramáticas do trágico e do épico. A plenitude de todo o território e do mar português estiveram sempre na linha da frente para o 1.º conde de Castro D’Aire. Não foi por acaso que alteou até ao Olimpo Luís de Camões, bem como outros escritores de língua portuguesa. António de Ataíde, devido às circunstâncias do tempo em que viveu, esteve profundamente ligado à gestão dos Habsburgos de Espanha. No entanto, no seu manuscrito, intitulado Borrador de huma arte poetica que se intenta/ua escrever, lavrado entre 1599 e 1602, observa-se um enaltecimento e uma pré-consciência da importância da língua portuguesa. Esse facto deve agora ser aprofundado, pois a edificação da Lusofonia é um processo em contínua pesquisa e evolução. Palavras-chave: Camões; epopeia; Lusíadas; Lusofonia; Poética.
description: artciencia.com, Revista de Arte, Ciência e Comunicação, N.º 24-25 (2021): Ano XII - Dezembro 2019 - Julho 2021
FUNCTIONAL DISSECTION OF THE HISTONE LYSINE DEMETHYLASE JMJD3
Creators: name: BURGOLD, THOMAS
Publisher: name: Universit� degli Studi di Milano
Year: 2011

description: Epigenetic control of developmental genes has emerged as a key mechanism in the acquisition of developmental competence. In particular, patterns of methylation at lysine 4 and 27 of histone H3 have been associated, respectively, with states of gene activation and repression that are developmentally regulated and are thought to underlie the establishment of lineage specific gene expression programs. Recent studies have provided fundamental insight into the problem of lineage specification by comparing global changes in chromatin and transcription between embryonic stem cells (ESCs) and neural stems cells (NSCs), points of departure and arrival for neural commitment, respectively. With these maps of the differentiated state in place, a central task is now to unravel the chromatin dynamics that enable these differentiation transitions between pluripotent ESCs and multipotent NSCs. In particular, the observation that lineage-specific genes repressed in ESCs by Polycomb-mediated histone H3 lysine 27 trimethylation (H3K27me3) are demethylated and derepressed in differentiated cells posited the existence of a H3K27-specific demethylase. In order to gain insight into the epigenetic mechanisms that enable lineage specification, we investigated in the first part of this work the early stages of neural commitment using as a model system the neural differentiation of mouse ESCs. Using a comprehensive expression analysis of JmjC genes, we identified Jmjd3 as a H3K27me3 demethylase that is specifically upregulated at the onset of neural differentiation. This study revealed that Jmjd3 controls the expression of key regulators and markers of neurogenesis and is required for commitment to the neural lineage. In the second part of this work, we have used a genetic loss-of-function approach to characterise the role of Jmjd3 in vivo. Mice lacking Jmjd3 die at birth from respiratory failure. A detailed characterisation of this neurodevelopmental phenotype demonstrated that the defect in respiratory rhythmogenesis upon loss of Jmjd3 is due to an abnormal maturation of the preB�tzinger complex (preB�tC), one of the two principal sites generating respiratory rhythm in mammals.
Non-invasive passive hand tremor control orthoses
Creators: name: Shah, Manthan
Publisher: name: University of British Columbia
Year: 2022

description: Hand tremors are one of the most prevalent neurodegenerative movement disorders leading to involuntary muscle movements majorly observed in old-age patients. Almost 25 M Parkinson’s Disease and Essential Tremor patients exhibit moderate to severe hand tremors worldwide. Tremors are not life-threatening, but they may cause substantial physical impairment and severe negative social consequences, possibly affecting the quality of life. Many drugs, medications, and neurosurgeries have been researched and are available in the market to treat tremors. However, due to the reduced effect of medication after prolonged use and possible complications of invasive neurosurgeries, a non-invasive wearable solution should be provided to dampen the hand tremors. Wearable devices have become a well-endorsed alternative for patients with moderate to severe hand tremors, although they have significant engineering challenges and risk factors. The development of wearable solutions has become prominent, and companies are in a race to develop the most effective device commercially. However, higher costs, larger weights, lack of experiments, limited application, and device efficiency are constraints for the most commercially available devices. This thesis is focused on developing and optimizing an affordable, lightweight, novel passive hand tremor attenuator. It comprises four major components: mathematical modeling and computational validation of the proposed absorber, design and fabrication of absorber, design, and fabrication of hand tremor simulator, and extensive testing of the absorber. Additionally, a comprehensive literature review was performed on classifying and diagnosing tremors, anatomy of the upper limb, medications, pharmacotherapies to cure tremors, and available wearable orthoses to suppress tremors. A mathematical model is developed with the concepts of mechanical vibrations to evaluate the dynamic response of the absorber computationally. A novel T-beam absorber is designed and fabricated with the mass-spring arrangement. Three tremor simulators were developed to evaluate the viability and assess the design parameters of the absorber. After wide-ranging experiments, the proposed absorber represented a higher amplitude reduction of up to 80% for a range of frequencies. Future research will focus on designing an ergonomic wearable device with a proposed absorber that can passively attenuate the tremors over the frequency range.
Enhanced photocatalytic dye degradation and hydrogen production ability of Bi$_{25}$FeO$_{40}$-rGO nanocomposite and mechanism insight
Creators: name: Basith, M. A.
name: Ahsan, Ragib
name: Zarin, Ishrat
name: Jalil, M. A.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: A comprehensive comparison between Bi$_{25}$FeO$_{40}$-reduced graphene oxide(rGO) nanocomposite and BiFeO$_{3}$-rGO nanocomposite has been performed to investigate their photocatalytic abilities in degradation of Rhodamine B dye and generation of hydrogen by water-splitting. The hydrothermal technique adapted for synthesis of the nanocomposites provides a versatile temperature-controlled phase selection between perovskite BiFeO$_{3}$ and sillenite Bi$_{25}$FeO$_{40}$. Both perovskite and sillenite structured nanocomposites are stable and exhibit considerably higher photocatalytic ability over pure BiFeO$_{3}$ nanoparticles and commercially available Degussa P25 titania. Notably, Bi$_{25}$FeO$_{40}$- rGO nanocomposite has demonstrated superior photocatalytic ability and stability under visible light irradiation than that of BiFeO$_{3}$-rGO nanocomposite. The possible mechanism behind the superior photocatalytic performance of Bi$_{25}$FeO$_{40}$-rGO nanocomposite has been critically discussed.
description: 13 pages, 6 figures
Identification of fault frequency variation in the envelope spectrum in the vibration-based local damage detection in possible changing load/speed conditions
Creators: name: Kuzio, Daniel
name: Zimroz, Radosław
name: Wyłomańska, Agnieszka
Publisher: name: arXiv
Year: 2024
Subjects: subject: Signal Processing (eess.SP)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: The problem of local damage diagnosis (based on the detection of impulsive and periodic signals) is discussed. Both features should be checked, as fault frequency must be linked to the true value calculated for a given machine and speed. The precise estimation of the fault frequency is hard due to several factors. If a speed fluctuation exists, it is solved by order analysis. A wider perspective is proposed here, namely, an automatic statistical approach to analyze the distribution of estimated fault frequencies. We propose a procedure to evaluate whether the fault frequency is constant or not. The algorithm uses frequency estimation based on peak detection in the envelope spectrum and statistical testing. We present simulation studies and industrial examples. We have found that if the fault frequency is not constant and its distribution does not follow Gaussian shape with minor variance, then one should use more advanced techniques, e.g. order analysis.
Novas investigações sobre a última Rainha de Portugal
Creators: name: Santos, Mário Beja
Publisher: name: artciencia.com, Revista de Arte, Ciência e Comunicação
Year: 2021

description: artciencia.com, Revista de Arte, Ciência e Comunicação, N.º 24-25 (2021): Ano XII - Dezembro 2019 - Julho 2021
O livro indispensável para compreender África após a descolonização
Creators: name: Santos, Licentiate History
Publisher: name: artciencia.com, Revista de Arte, Ciência e Comunicação
Year: 2021

description: artciencia.com, Revista de Arte, Ciência e Comunicação, N.º 24-25 (2021): Ano XII - Dezembro 2019 - Julho 2021
MORPHOLOGY OF THE FACE AS A POSTMORTEM PERSONAL IDENTIFIER
Creators: name: CAPLOVA, ZUZANA
Publisher: name: Universit� degli Studi di Milano
Year: 2018

description: The human face carries some of the most individualizing features suitable for the personal identification. Facial morphology is used for the face matching of living. An extensive research is conducted to develop the matching algorithm to mimic the human ability to recognize and match faces. Human ability to recognize and match faces, however, is not errorless and it serves as the main argument precluding the visual facial matching from its use as an identification tool. The human face keeps its individuality after death. Compared to the faces of living, the faces of deceased are rarely used or researched for the face matching. Different factors influence the appearance of the face of the deceased compared to the face of the living, namely the early postmortem changes and decomposition process. On the other hand, the literature review showed the use of visual recognition in multiple cases of identity assessment after the natural disasters. Presented dissertation thesis is composed of several projects focused on the possibility of personal identification of the decedents solely based on the morphology of their face. Dissertation explains the need for such identification and explores the error rates of the visual recognition of deceased, the progress of facial changes due to the early decomposition and the possibility of utilization of soft biometric traits, specifically facial moles. Lastly, the dissertation presents the use of shape index (s) as a quality indicator of three different 3D scanners aimed towards the most suitable method for obtaining facial postmortem 3D images.
Portugueses e Espanhóis na Oceânia
Creators: name: Santos, Licentiate History
Publisher: name: artciencia.com, Revista de Arte, Ciência e Comunicação
Year: 2021

description: artciencia.com, Revista de Arte, Ciência e Comunicação, N.º 24-25 (2021): Ano XII - Dezembro 2019 - Julho 2021
STEM CELL-LIKE PROPERTIES OF MEMORY T CELLS IN HUMAN IMMUNE RECONSTITUTION
Creators: name: ZANON, VERONICA
Publisher: name: Universit� degli Studi di Milano
Year: 2018

description: ABSTRACT The memory T cell compartment comprises a plethora of subsets that are diverse at the functional, transcriptional and metabolic level. T memory stem cells (TSCM) are the least differentiated subset endowed with superior immune reconstitution capacity, anti-tumor activity and long-term persistence compared to more differentiated progeny in preclinical models. However, their role in human T cell recovery remains undetermined. In the first part of my work, I investigate the dynamics of T cell reconstitution in human haploidentical bone marrow transplantation (haplo-BMT) with post-transplant cyclophosphamide (pt-Cy) and provide evidence that donor antigen-specific na�ve (TN)- derived TSCM cells survive pt-Cy and are the most abundant circulating T cell population in the early days after transplantation. I further demonstrate that these cells later contribute to peripheral reconstitution by differentiating into effector cells. With these experiments, I define the cellular basis of human T cell reconstitution following haploidentical transplantation with pt-Cy and propose to employ naive-derived TSCM cells in the clinical setting to overcome immunodeficiency. However, the clinical use of these cells is limited by their paucity ex vivo. Therefore, I dedicate the second part of this work to investigate the biological and molecular mechanisms involved in the generation and expansion of TSCM cells from CD8+ TN precursors. I show that curtailed T-cell receptor stimulation curbs effector CD8+ T-cell differentiation and allows the generation of CD45RO? CD45RA+CCR7+CD27+CD95+ -phenotype cells from highly purified TN precursors, resembling naturally-occurring TSCM. These cells proliferate extensively in vitro and in vivo, express low amounts of effector-associated genes and transcription factors and undergo considerable self-renewal in response to IL-15 while retaining effector differentiation potential. Such a phenotype is associated with a lower number of mitochondria compared to highly-activated effector T cells committed to terminal differentiation. These results shed light on the molecular signals that are required to generate high numbers of long-lived memory T cells with potential application in adoptive cell transfer immunotherapy.
Intent Contrastive Learning for Sequential Recommendation
Creators: name: Chen, Yongjun
name: Liu, Zhiwei
name: Li, Jia
name: McAuley, Julian
name: Xiong, Caiming
Publisher: name: arXiv
Year: 2022
Subjects: subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Users' interactions with items are driven by various intents (e.g., preparing for holiday gifts, shopping for fishing equipment, etc.).However, users' underlying intents are often unobserved/latent, making it challenging to leverage such latent intents forSequentialrecommendation(SR). To investigate the benefits of latent intents and leverage them effectively for recommendation, we proposeIntentContrastiveLearning(ICL), a general learning paradigm that leverages a latent intent variable into SR. The core idea is to learn users' intent distribution functions from unlabeled user behavior sequences and optimize SR models with contrastive self-supervised learning (SSL) by considering the learned intents to improve recommendation. Specifically, we introduce a latent variable to represent users' intents and learn the distribution function of the latent variable via clustering. We propose to leverage the learned intents into SR models via contrastive SSL, which maximizes the agreement between a view of sequence and its corresponding intent. The training is alternated between intent representation learning and the SR model optimization steps within the generalized expectation-maximization (EM) framework. Fusing user intent information into SR also improves model robustness. Experiments conducted on four real-world datasets demonstrate the superiority of the proposed learning paradigm, which improves performance, and robustness against data sparsity and noisy interaction issues.
NEW INSIGHTS IN BONE BIOLOGY FROM EXOME SEQUENCING OF RARE SKELETAL DISEASES
Creators: name: PALAGANO, ELEONORA
Publisher: name: Universit� degli Studi di Milano
Year: 2018

description: Whole exome sequencing (WES) is a powerful tool to identify new molecules involved in skeletal homeostasis. In particular we used WES to establish the molecular diagnosis of two particular skeletal diseases: osteopetrosis and the acrofrontofacionasal dysostosis 1 (AFFND1). The osteopetroses are a group of rare bone diseases characterized by increased bone density due to the failure in bone resorption. Due to their genetic heterogeneity, WES represents a valuable strategy to identify the genetic defect. We analyzed osteopetrotic patients with autosomal dominant osteopetrosis (ADO) and autosomal recessive osteopetrosis (ARO), which is the most severe form. In our cohort we performed molecular diagnosis of 4 ADOI or ADOII patients that carried mutations in the LRP5 and CLCN7 genes, respectively. The analysis of ARO patients confirmed TCIRG1 as the most frequently mutated gene, identified mutations in the other known ARO genes and in genes very rarely associated with osteopetrosis, namely FERMT3 and USB1. Of note, we demonstrated the causative role of four deep intronic mutations in TCIRG1 gene and two different synonymous changes in the TCIRG1 and CLCN7 genes in the pathogenesis of the disease. In addition, WES helped in the differential diagnosis in a patient who was found to bear a mutation in the FAM20C gene, known to cause Raine syndrome. Regarding AFFND1, this is an extremely rare syndrome, comprising facial and skeletal abnormalities, short stature and intellectual disability. WES found a novel truncating mutation in the neuroblastoma-amplified sequence (NBAS) gene in two Indian patients (c.6237-3C>G). This mutation impaired NBAS functions in HEK293T cells overexpressing the truncated NBAS protein. Furthermore, we demonstrated that NBAS expression in mouse embryos was compatible with a role in bone and brain development and that the depletion of endogenous z-nbas in fish embryos resulted in defective morphogenesis of chondrogenic cranial skeletal elements. Overall, we provided evidence supporting the hypothesis of a causative role of the mutated NBAS gene in the pathogenesis of AFFND1. In conclusion, we effectively exploited WES in the genetic diagnosis of rare skeletal diseases. We also highlighted potential limitations of this approach, specifically with respect to deep intronic mutations and synonymous changes, and underlined the importance to complement WES with analysis at the transcript level and functional validation, when possible.
A nossa guerra civil do século XIX: O porquê do equívoco liberal
Creators: name: Santos, Licentiate History
Publisher: name: artciencia.com, Revista de Arte, Ciência e Comunicação
Year: 2021

description: artciencia.com, Revista de Arte, Ciência e Comunicação, N.º 24-25 (2021): Ano XII - Dezembro 2019 - Julho 2021
Disrupting British imperialism : ayahs' intersectional role in the colonial home and their impact on British children, 1757-1947
Creators: name: Marshall, Morgan
Publisher: name: University of British Columbia
Year: 2022

description: Since the mid-eighteenth century, British families have relied on South Asian women known as ayahs to provide complete childcare for their white children in colonial India. Indian ayahs lived and worked within the British colonial home as nannies, domestic servants, nurses and, occasionally, wet nurses, helping British families thrive in the isolated environment. Despite ayahs’ intimate employment within the British home, little scholarship has investigated the intricacies of their employment and impact on the colonial home. This master’s research aims to fill this knowledge gap, arguing that the employment of ayahs fundamentally disrupted the empire’s hegemonic power by crossing racial, gendered, and hierarchical barriers to create mother-like relationships with upper-middle-class British children. Ayahs’ disruption of racial superiority and the reproduction of colonial power within British India did not go unrecognized. The possible ‘cultural contamination’ of British children spurred imperial fears amongst the British and attempts to regulate ayahs’ impact were established. It begs the question of how ayahs’ subordination in the household was a product of colonialism and how it disrupted British imperial power. This thesis uses an intersectional feminist framework and an analysis of visual culture to deconstruct the inner workings of the colonial home, revealing a more significant role of Indian women in this period in history.
Multidimensional Cybersecurity Framework for Strategic Foresight
Creators: name: Onwubiko, Cyril
name: Ouazzane, Karim
Publisher: name: arXiv
Year: 2022
Subjects: subject: Cryptography and Security (cs.CR)
subject: Machine Learning (cs.LG)
subject: Social and Information Networks (cs.SI)
subject: FOS: Computer and information sciences

description: Cybersecurity is now at the forefront of most organisational digital transformative agendas and National economic, social and political programmes. Hence its impact to society can no longer be seen to be one dimensional. The rise in National cybersecurity laws and regulations is a good indicator of its perceived importance to nations. And the recent awakening for social and ethical transparency in society and coupled with sustainability issues demonstrate the need for a paradigm shift in how cybersecurity discourses can now happen. In response to this shift, a multidimensional cybersecurity framework for strategic foresight underpinned on situational awareness is proposed. The conceptual cybersecurity framework comprising six domains such as Physical, Cultural, Economic, Social, Political and Cyber, is discussed. The guiding principles underpinning the framework are outlined, followed by in-depth reflection on the Business, Operational, Technological and Human (BOTH) factors and their implications for strategic foresight for cybersecurity.
description: 31 pages, 7 figures
L'ATTIVIT� CRITICO-EDITORIALE DI SERGIO ANTONIELLI
Creators: name: CRIPPA, MARIE LOUISE
Publisher: name: Universit� degli Studi di Milano
Year: 2018

description: My study reconstructs the intellectual profile of Sergio Antonielli, writer, critic and professor of Modern and Contemporary Italian Literature at the University of Milan in the second half of twentieth century. My research consisted of analysis of essays, articles and monographs dedicated to Italian contemporary writers and examination of unpublished documents kept at ?Apice? (Archives of the Word, Image and Editorial Communication), and at the ?Arnoldo and Alberto Mondadori Foundation?: a rich correspondence with influential figures of italian literature, notes for lectures and speeches, reading opinions written for Mondadori and Editori Riuniti. Through the work of Sergio Antonielli, it is possible to retrace critical dynamics of the twentieth century (Ermetismo and post-Ermetismo, Realism and neo-realism), creative phases of some poets (Eugenio Montale, Vittorio Sereni, Andrea Zanzotto, Mario Luzi) and processes of the publishing companies in the second half of twentieth century.
Spectroscopic and photometric study of the new eclipsing polar Gaia23cer
Creators: name: Kolbin, A. I.
name: Pavlenko, E. P.
name: Kochkina, V. Yu.
name: Vinokurov, A. S.
name: Shugarov, S. Yu.
name: Sosnovskij, A. A.
name: Antonyuk, K. A.
name: Antonyuk, O. I.
name: Pit, N. V.
name: Suslikov, M. V.
name: Galimova, E. K.
name: Borisov, N. V.
name: Burenkov, A. N.
name: Spiridonova, O. I.
Publisher: name: arXiv
Year: 2024
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present the results of the optical study of the new eclipsing polar Gaia23cer. We analyzed the brightness variability of the polar in high ($\langle r \rangle \approx 16.5\mathrm{\,mag}$) and low ($\langle r \rangle \approx 19.2\mathrm{\,mag}$) states. The system has an orbital period $P_{orb} = 102.0665 \pm 0.0015$ min and exhibits deep eclipses with a duration $Δt_{ecl} = 401.30 \pm 0.81$ s. The spectra have a red cyclotron continuum with the Zeeman H$α$ absorption triplet forming in a magnetic field with a strength of $15.2 \pm 1.1$ MG. The source of emission lines has a high radial velocity semiamplitude ($K\approx 450$km/s) and its eclipse lags behind the eclipse of the white dwarf. The mass $M_1=0.79 \pm 0.03 M_{\odot}$ and temperature $T=11350 \pm 650 K$ of the white dwarf have been found by modelling the spectral energy distribution. The eclipse duration corresponds to a donor mass $M_2 = 0.10-0.13M_{\odot}$ and an orbital inclination $i=84.3-87.0^{\circ}$. The donor temperature was estimated to be $T\approx 2900K$ by modelling the elliptical variability and eclipse depth.
A Europa entre 1950 e os nossos dias, numa obra-prima de historiografia
Creators: name: Santos, Licentiate History
Publisher: name: artciencia.com, Revista de Arte, Ciência e Comunicação
Year: 2021

description: artciencia.com, Revista de Arte, Ciência e Comunicação, N.º 24-25 (2021): Ano XII - Dezembro 2019 - Julho 2021
Um olhar audacioso, perspicaz, sobre os fundamentos da identidade europeia
Creators: name: Santos, Licentiate History
Publisher: name: artciencia.com, Revista de Arte, Ciência e Comunicação
Year: 2021

description: artciencia.com, Revista de Arte, Ciência e Comunicação, N.º 24-25 (2021): Ano XII - Dezembro 2019 - Julho 2021
Os Ricos, por Maria Filomena Mónica
Creators: name: Santos, Licentiate History
Publisher: name: artciencia.com, Revista de Arte, Ciência e Comunicação
Year: 2021

description: artciencia.com, Revista de Arte, Ciência e Comunicação, N.º 24-25 (2021): Ano XII - Dezembro 2019 - Julho 2021
Intelligent Reflecting Surface-Aided Spectrum Sensing for Cognitive Radio
Creators: name: Lin, Shaoe
name: Zheng, Beixiong
name: Chen, Fangjiong
name: Zhang, Rui
Publisher: name: arXiv
Year: 2022
Subjects: subject: Information Theory (cs.IT)
subject: Emerging Technologies (cs.ET)
subject: Signal Processing (eess.SP)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Spectrum sensing is a key enabling technique for cognitive radio (CR), which provides essential information on the spectrum availability. However, due to severe wireless channel fading and path loss, the primary user (PU) signals received at the CR or secondary user (SU) can be practically too weak for reliable detection. To tackle this issue, we consider in this letter a new intelligent reflecting surface (IRS)-aided spectrum sensing scheme for CR, by exploiting the large aperture and passive beamforming gains of IRS to boost the PU signal strength received at the SU to facilitate its spectrum sensing. Specifically, by dynamically changing the IRS reflection over time according to a given codebook, its reflected signal power varies substantially at the SU, which is utilized for opportunistic signal detection. Furthermore, we propose a weighted energy detection method by combining the received signal power values over different IRS reflections, which significantly improves the detection performance. Simulation results validate the performance gain of the proposed IRS-aided spectrum sensing scheme, as compared to different benchmark schemes.
description: Accepted by IEEE Wireless Communications Letters (5 pages, 4 figures)
O maior grito pode ser um silêncio: Dois génios em correspondência de leitura obrigatória
Creators: name: Santos, Mário Beja
Publisher: name: artciencia.com, Revista de Arte, Ciência e Comunicação
Year: 2021

description: artciencia.com, Revista de Arte, Ciência e Comunicação, N.º 24-25 (2021): Ano XII - Dezembro 2019 - Julho 2021
Spectroscopic Observations of the Galex Nearby Young Star Survey Sample. 1. Nearby Moving Group Candidates
Creators: name: Nagananda, Navya
name: Vican, Laura
name: Zuckerman, Ben
name: Rodriguez, David
name: Binks, Alexander
name: Kastner, Joel
Publisher: name: arXiv
Year: 2024
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The GALEX Nearby Young Star Search (GALNYSS) yielded the identification of more than 2000 late-type stars that, based on their ultraviolet and infrared colors and pre-Gaia proper motions, are potentially of age < 200 Myr and lie within ~120 pc of Earth. We present the results of a campaign of medium- and high-resolution optical spectroscopy of 471 GALNYSS stars aimed at confirming their youth and their potential membership in nearby young stellar moving groups. We present radial velocity (RV), Li absorption, and H-$α$ emission measurements for these spectroscopically observed GALNYSS stars, and assess their Li absorption and optical emission-line properties and infrared excesses. Our RV measurements are combined with literature and Gaia DR3 RV measurements and Gaia DR3 astrometry and photometry to obtain the spatiokinematics and color-magnitude positions of GALNYSS stars. We use these results to assess membership in the TW Hya, Tuc-Hor, Carina, Columba, and Argus Associations and the $β$-PMG and AB Dor moving groups. We have identified 132 stars as candidate members of these seven groups; roughly half of these candidates are newly identified on the basis of data presented here. At least one-third of the 132 candidates are spectroscopic and/or photometric binaries and/or have comoving (visual) binary companions in Gaia DR3. The contingent of young, low-mass stars in the solar vicinity we identify here should provide excellent subjects for future direct imaging exoplanet surveys and studies of the early evolution of low-mass stars and their planetary progeny.
description: The paper is accepted by the Open Journal of Astrophysics
A Mentira Monárquica: Recensão ao Opúsculo de Alfredo Pimenta
Creators: name: Araújo, Jorge
Publisher: name: artciencia.com, Revista de Arte, Ciência e Comunicação
Year: 2021

description: Recensão ao Opúsculo de Alfredo Pimenta A Mentira monarchica: analyse do momento actual da politica portugueza. Coimbra: Centro Republicano de Coimbra, 1906.
description: artciencia.com, Revista de Arte, Ciência e Comunicação, N.º 24-25 (2021): Ano XII - Dezembro 2019 - Julho 2021
Functional characterization of Mest and its imprinted gametic differentially methylated region
Creators: name: Ha, Amanda
Publisher: name: University of British Columbia
Year: 2022

description: Genomic imprinting is an epigenetic phenomenon by which the expression of certain genes follows a parent-of-origin-specific pattern. The sub-proximal end of mouse Chr 6 contains an imprinted domain comprised of the paternally expressed gene Mest, and the maternally expressed genes Copg2 and Klf14. The Mest locus harbors the only gametic differentially methylated region (gDMR) in the region, which may act as an Imprinting Control Region for the coordinated regulation of these three imprinted genes. The Mest-Klf14 imprinted domain shares syntenic homology with human Chr 7q32. Therefore, loss of Mest function, or Klf14 overexpression may contribute to the maternal uniparental disomy 7 (mUPD7) growth retardation phenotype associated with Sliver- Russell syndrome (SRS). Here, I investigate the function of Mest, and its gDMR. In Chapter 3, I leveraged a previously generated Mest KO mouse line to characterize the function of Mest in developmental pathways. Embryonic growth retardation observed in Mest KO mice was independent of gross placental abnormalities in vivo, but associated with altered Wnt signalling in cell assays. Based on additional proteomic and metabolomic characterization, I hypothesize that the putative epoxide hydrolase, known as MEST, acts upon metabolites within the endoplasmic reticulum lumen. In Chapter 4, I explored the function of the Mest gDMR. While the imprinted regulation of both Mest and Copg2 has been well documented, the mechanism of Klf14 imprinting is unknown. Klf14 expression is lost in embryos lacking maternal methylation iii genome-wide, indicating that maternally-inherited DNA methylation (DNAme) is paradoxically required for its expression. Through CRISPR-Cas9 mutagenesis and allele-specific chromosome conformation experiments in F1 embryonic stem cells, I demonstrate that the Mest gDMR regulates imprinting of Klf14 through long-range chromatin looping, permitting differential promoter-enhancer interactions between parental alleles. I propose a model whereby CTCF binding to the unmethylated paternal Mest gDMR structures paternal allele-specific sub-TADs required for Klf14 silencing. Altogether, my results illustrate both the function and mechanisms regulating imprinting at the Mest-Klf14 imprinted domain which may impact the management of patients with Silver-Russell or metabolic syndromes.