cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Patient safety in English general practice : the role of routinely collected data in detecting adverse events
Creators: name: Tsang, Carmen
Publisher: name: Imperial College London
Year: 2013

description: The use of routinely collected, or administrative, data for measuring and monitoring patient safety in primary care is a relatively new phenomenon. With increasing availability of data from different sources and care settings, their application for adverse event surveillance needs evaluation. In this thesis, I demonstrated that data routinely collected from primary care and secondary care can be applied for internal monitoring of adverse events at the general practice-level in England, but these data currently have limited use for safety benchmarking in primary care. To support this statement, multiple approaches were adopted. In the first part of the thesis, the nature and scope of patient safety issues in general practice were defined by evidence from a literature review and informal consultations with general practitioners (GPs). Secondly, using these two methods, measures of adverse events based on routinely collected healthcare data were identified. Thirdly, clinical consensus guided the selection of three candidate patient safety indicators for investigation; the safety issues explored in this thesis were recorded incidents with designated adverse event diagnostic codes and complications associated with two common diseases, emergency admissions for diabetic hyperglycaemic emergencies (diabetic ketoacidosis, DKA and hyperglycaemic hyperosmolar state, HHS) and cancer. In the second part of the thesis, the contributions of routinely collected data to new knowledge about potentially preventable adverse events in England were considered. Data from a primary care trust (NHS Brent), national primary care data (from the General Practice Research Database, GPRD) and secondary care data (Hospital Episode Statistics, HES) were used to explore the epidemiology of, and patient characteristics associated with, coded adverse events and emergency admissions for diabetic hyperglycaemic emergencies and cancer. Low rates of adverse events were found, with variation by individual patient factors. Finally, recommendations were made on extending the uses of routinely collected data for patient safety monitoring in general practice.
title: Data Stewardship Maturity Report for GHRSST Level 2P Global Bulk Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-16 satellite (GDS version 1)
Creators: name: Ionin, Raisa
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00282
title: Data Stewardship Maturity Report for GHRSST Level 2P Global Bulk Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-17 satellite (GDS version 1)
Creators: name: Ionin, Raisa
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00281
Supplementary Material for: Association of Serum Potassium with All-Cause Mortality in Patients with and without Heart Failure, Chronic Kidney Disease, and/or Diabetes
Creators: name: Collins, A.J.
name: Pitt, B.
name: Reaven, N.
name: Funk, S.
name: McGaughey, K.
name: Wilson, D.
name: Bushinsky, D.A.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Background: The relationship between serum potassium, mortality, and conditions commonly associated with dyskalemias, such as heart failure (HF), chronic kidney disease (CKD), and/or diabetes mellitus (DM) is largely unknown. Methods: We reviewed electronic medical record data from a geographically diverse population (n = 911,698) receiving medical care, determined the distribution of serum potassium, and the relationship between an index potassium value and mortality over an 18-month period in those with and without HF, CKD, and/or DM. We examined the association between all-cause mortality and potassium using a cubic spline regression analysis in the total population, a control group, and in HF, CKD, DM, and a combined cohort. Results: 27.6% had a potassium <4.0 mEq/L, and 5.7% had a value ≥5.0 mEq/L. A U-shaped association was noted between serum potassium and mortality in all groups, with lowest all-cause mortality in controls with potassium values between 4.0 and <5.0 mEq/L. All-cause mortality rates per index potassium between 2.5 and 8.0 mEq/L were consistently greater with HF 22%, CKD 16.6%, and DM 6.6% vs. controls 1.2%, and highest in the combined cohort 29.7%. Higher mortality rates were noted in those aged ≥65 vs. 50-64 years. In an adjusted model, all-cause mortality was significantly elevated for every 0.1 mEq/L change in potassium <4.0 mEq/L and ≥5.0 mEq/L. Diuretics and renin-angiotensin-aldosterone system inhibitors were related to hypokalemia and hyperkalemia respectively. Conclusion: Mortality risk progressively increased with dyskalemia and was differentially greater in those with HF, CKD, or DM.
title: Data Stewardship Maturity Report for GHRSST Level 2P Global Skin Sea Surface Temperature from the Infrared Atmospheric Sounding Interferometer (IASI) on the MetOp-A satellite (GDS version 2)
Creators: name: Ionin, Raisa
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00280
title: Data Stewardship Maturity Report for GHRSST Level 2P Global skin Sea Surface Temperature from the Infrared Atmospheric Sounding Interferometer (IASI) on the Metop-B satellite (GDS V2) produced by OSI SAF (GDS version 2)
Creators: name: Ionin, Raisa
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00279
Relationship between glucocorticoid dose and adverse events in systemic lupus erythematosus: data from a randomized clinical trial
Creators: name: S Emamikia
name: C Gentline
name: K Chatzidionysiou
name: L Arnaud
name: R Van Vollenhoven
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 60506 Virology

description: Objective: The aim was to obtain a better understanding of the relationship between exposure to glucocorticoids (GCs) and adverse events (AEs) reported in a randomized controlled trial (RCT) in systemic lupus erythematosus (SLE) patients. Method: We used data from the BLISS-76 trial on belimumab. The data were accessed through an agreement under the SHARE mechanism. AEs were grouped according to medical relevance, i.e. based on similarity of symptoms and pathophysiology. We studied the relationship between AEs and exposure to GCs at baseline and at any time-point, and compared the frequencies of each AE and groups of AEs between tertiles of cumulative GC dose. Results: In total, 991 AEs were reported in the 819 patients of the trial. The frequencies of anaemia, pyrexia, oral herpes, and malaise were significantly higher (p Conclusion: This study highlights the feasibility of post-hoc analyses of RCTs using the SHARE mechanism and demonstrates the association of GCs with various AEs. Contrary to expectations, there were also associations between lower cumulative GC dose and several other AEs.
title: Data Stewardship Maturity Report for GHRSST L2P Gridded Global Subskin Sea Surface Temperature from the Tropical Rainfall Mapping Mission (TRMM) Microwave Imager (TMI) (GDS version 1)
Creators: name: Ionin, Raisa
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00278
A window on the ageing brain : Imaging synapses and their dynamics in vivo
Creators: name: Grillo, Federico William
Publisher: name: Imperial College London
Year: 2013

description: The ageing process has an enormous impact on the human body and it represents a major risk factor for a number of diseases. Ageing is also associated with a progressive cognitive decline mainly involving the memory domain. Up to date many studies have investigated the structural and functional changes that occur in the ageing brain. Rather than neuronal loss, it is now widely accepted that synaptic impairments underlie the decreased cognitive performance. Such studies point to reduced synaptic density and plasticity, in specific brain regions, during ageing. However, most studies so far made use of either post-mortem or ex vivo preparations. Thus, the key question addressed in this thesis is to what extent synaptic elements are dynamic in the intact aged brain. A combination of in vivo two-photon imaging, correlated two-photon-electron microscopy and novel computational tools was used to study synaptic boutons in the aged mouse somatosensory cortex. Unexpectedly, circuit-specific increased rates of bouton formation, elimination, and destabilization were found. Age related increased dynamics greatly affected large (i.e., strong) boutons, thought to encode long-term memory, as opposed to smaller ones. The rigorous measurement of the size and location of axonal boutons, achieved for the first time in vivo, showed that while the average density and size of boutons was not affected by ageing, bouton size changes were greater in the aged animals. Such increased size fluctuations were again confined to larger, persistent boutons., Long-term memory impairment, as assessed in a novel behavioural task, was therefore associated with increased, rather than decreased, synaptic destabilization and dynamics, suggesting the existence of a novel mechanism underlying age related cognitive decline.
title: Verwendung des TVT-Bandes bei der laparoskopischen Nephropexie zur Behandlung der symptomatischen Nephroptose
Creators: name: Ameli, G.
name: Weibl, P.
name: Prüger, L.
name: Hübner, W. A.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Die Nephropexie steht seit ihrer Einführung zur operativen Behandlung der symptomatischen Nephroptose immer wieder zur Diskussion. Die Indikation zur operativen Therapie stellt sich bei radiologisch und nuklearmedizinisch nachgewiesener Nephroptose mit Funktionseinschränkung bzw.[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
Digitales Bauen: Prozesse neu denken
Creators: name: Huber, Manfred
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2019
Subjects: Bauwirtschaft
BIM-Methode
Zukunft
Prozesse
VDC
IPD

description: Prozesse neu denken. Methoden und Technologien für innovatives Planen, Bauen und Bewirtschaften.
title: Data Stewardship Maturity Report for GHRSST Level 2P Gridded Global Subskin Sea Surface Temperature from WindSat polarimetric radiometer on the Coriolis satellite (GDS version 1)
Creators: name: Ionin, Raisa
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00277
Evaluating integrated Neglected Tropical Disease (NTD) control strategies: cost, effectiveness and sustainability of the NTD control programme in Uganda
Creators: name: Fleming, Fiona
Publisher: name: Imperial College London
Year: 2014

description: The predicted costs and savings of integrated preventive chemotherapy (IPCT) for the Neglected Tropical Diseases (NTDs) have been proposed by a number of prior studies. The principle aims of the research presented in this thesis were to determine the cost, effectiveness and sustainability of the Ugandan integrated NTD Control Programme (NTDCP). Annual programme costs were prospectively and retrospectively collected at all levels of programme implementation in twelve districts over three years. Overall cost per person treated for IPCT were, financial (excluding purchased drugs) US$0.17; economic (excluding purchased and donated) US$0.65 and full economic cost per person (including value of all drugs) US$12.06. When costs of the NTDCP were compared to the combined costs of the pre-integration stand-alone (SA) control programmes in Uganda, cost savings of 54% to 72% were achieved. The IPCT was also effective with over 43 million treatments delivered and 2,444,714 disability-adjusted life years (DALYs) averted; and highly cost-effective at an estimated economic cost of US$16.50 per NTD case averted and US$10.19 per DALY averted. Using a novel approach to measure community drug distributors (CDDs) involvement in IPCT; pictorial diaries collected prospective data on their time allocation. On average 2.5 working weeks were spent on NTDCP activities per year by a CDD. This meant a significant reduction in time available for subsistence and income generating engagements. With each incremental drug delivery required over a mass IPCT campaign i.e. the number of times a CDD delivered a NTD drug package to communities, economic costs increased. Moreover, as CDDs took more time to complete NTDCP activities their programme coverage performance decreased. Motivation for the programme was acknowledged as low and CDDs felt undervalued. Finally the applications and implications of the thesis results are discussed with regards to programme effectiveness and sustainability and in the context of NTD control and elimination.
title: Data Stewardship Maturity Report for GHRSST Level 3C Global Subskin Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on MetOp-A (GDS version 2)
Creators: name: Ionin, Raisa
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00276
Formal Institutions and Environmental Factors Framing Entrepreneurship in Croatia
Creators: name: Fuduric, Nikolina
Publisher: name: Aalborg Universitet
Year: 2008
Subjects: subject: Formal institutions
subject: environmental factors
subject: context of entrepreneurhsip
subject: eastern europe
subject: Croatia
subject: 330 - Wirtschaft

description: This paper has two purposes. First, it provides an assessment of the factors framing entrepreneurship in Croatia and how they influence the predominantly necessity-oriented entrepreneurship in the nation. The factors considered include – economics, formal institutions, culture, the industrial structure, human capital and social capital. The second purpose is to present possibilities on how different institutions, through their policies, programs and implementing organizations, impact the above factors. Understanding the sources influencing necessity entrepreneurship is important because the Croatian government’s goal is to reach 75% of the EU25 mean GDP by 2013, partly using entrepreneurship development as an engine of this growth.
Characterisation of the Haemodynamic Response Function (HRF) in the neonatal brain using functional MRI
Creators: name: Arichi, Tomoki
Publisher: name: Imperial College London
Year: 2012

description: Background: Preterm birth is associated with a marked increase in the risk of later neurodevelopmental impairment. With the incidence rising, novel tools are needed to provide an improved understanding of the underlying pathology and better prognostic information. Functional Magnetic Resonance Imaging (fMRI) with Blood Oxygen Level Dependent (BOLD) contrast has the potential to add greatly to the knowledge gained through traditional MRI techniques. However, it has been rarely used with neonatal subjects due to difficulties in application and inconsistent results. Central to this is uncertainity regarding the effects of early brain development on the Haemodynamic Response Function (HRF), knowledge of which is fundamental to fMRI methodology and analysis. Hypotheses: (1) Well localised and positive BOLD functional responses can be identified in the neonatal brain. (2) The morphology of the neonatal HRF differs significantly during early human development. (3) The application of an age-appropriate HRF will improve the identification of functional responses in neonatal fMRI studies. Methods: To test these hypotheses, a systematic fMRI study of neonatal subjects was carried out using a custom made somatosensory stimulus, and an adapted study design and analysis pipeline. The neonatal HRF was then characterised using an event related study design. The potential future application of the findings was then tested in a series of small experiments. Results: Well localised and positive BOLD functional responses were identified in neonatal subjects, with a maturational tendency towards an increasingly complex pattern of activation. A positive amplitude HRF was identified in neonatal subjects, with a maturational trend of a decreasing time-to-peak and increasing positive peak amplitude. Application of the empirical HRF significantly improved the precision of analysis in further fMRI studies. Conclusions: fMRI can be used to study functional activity in the neonatal brain, and may provide vital new information about both development and pathology.
The role of the RNA binding protein FUS in androgen signalling
Creators: name: Culley, Rachel Louise
Publisher: name: Imperial College London
Year: 2012

description: The multi-functional RNA binding protein FUS was identified as an androgen down-regulated target in a 2D proteomic screen in the LNCaP cell line. This screen was designed to identify novel markers and therapeutic targets for prostate cancer. Cell cycle analysis and growth assays revealed that increased FUS levels in LNCaP cells resulted in inhibition of the androgen-dependent G1-S cell cycle transition and induced apoptosis. This is brought about, in part, via the FUS-dependent modulation of the expression of G1- S check-point regulatory proteins, including decreased expression of Cyclin D1. Therefore, we have identified FUS as a key link between androgen signalling and cell cycle regulation. FUS also modulates androgen signalling by repressing Androgen Receptor (AR) activity. FUS is known to interact with the DNA binding domain of some nuclear receptors, and a mammalian 2-hybrid interaction assay revealed a ligand-dependent interaction between FUS and the AR that required the FUS RNA recognition motif. Transcription assays demonstrated that FUS is a novel co-repressor of AR activity, and quantitative real time PCR showed that increasing FUS levels down-regulated androgen-regulated gene expression in LNCaP cells, whilst reducing FUS levels resulted in an increase of the androgen-regulated gene TMPRSS2. Investigation into the mechanism(s) by which FUS represses AR activity revealed that FUS contains an NH2-terminal activation domain (amino acids 1-366) that is consistent with the AR transcriptional repression domain. Furthermore, the FUS NH2- terminal interacts with co-activators, including SRC-1, suggesting FUS may repress AR activity by competition with co-activator activity. Recent studies in Dr Charlotte Bevan’s laboratory demonstrated an inverse correlation between FUS expression and Gleason grade in human prostate tumours. This, combined with these findings that FUS is an inhibitor of androgen-dependent growth which is, in part, via repression of the AR, suggests that FUS is a key regulator in AR signalling and prostate cancer progression, and may be a novel tumour suppressor.
Additional file 2 of The epidemiologic impact and cost-effectiveness of new tuberculosis vaccines on multidrug-resistant tuberculosis in India and China
Creators: name: Weerasuriya, Chathika K
name: Harris, Rebecca C
name: McQuaid, C Finn
name: Bozzani, Fiammetta
name: Ruan, Yunzhou
name: Li, Renzhong
name: Li, Tao
name: Rade, Kirankumar
name: Rao, Raghuram
name: Ginsberg, Ann M
name: Gomez, Gabriela B
name: White, Richard G
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 2. Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist.
Es lohnt sich. Unternehmensgründungen in der Schweiz
Creators: name: Meyer, Rolf
Publisher: name: Berufsverband für Coaching, Supervision und Organisationsberatung
Year: 2015
Subjects: subject: Entrepreneurship
subject: startup
subject: coaching
subject: 330 - Wirtschaft

description: Fakten zur Unternehmensgründung in der Schweiz mit Fokus auf den Entscheid zur Selbständigkeit als Coach.
title: Data Stewardship Maturity Report for GHRSST Level 3P Global Subskin Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the MetOp-A satellite (GDS version 1)
Creators: name: Ionin, Raisa
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00275
title: Prolapsbedingte Blasenentleerungsstörungen und deren Heilung: Abhängigkeit von Prolapsgrad, Prolapslokalisation und Erfolg der Prolapskorrektur
Creators: name: Liedl, B.
name: Rakhimbayeva, A.
name: Kohl, M.
name: Witczak, M.
name: Abenhardt, M.
name: Himmler, M.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Wesentliche Ursache prolapsbedingter Blasenentleerungsstörungen sollen Minderung der Öffnungkräfte bei Miktion durch bindegewebige Lockerungen sein (Petros und Ulmsten 1993), so dass eine obstruktive Miktion resultiert. Wir analysierten die Rohdaten der Propel-Studie (ClinicalTrials.gov-Identifier:NCT00638235),[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
The Role of Subcellular Distribution upon Signalling by Polyomavirus Middle Tumour-antigen
Creators: name: Zhou, Yunsi
Publisher: name: Imperial College London
Year: 2013

description: The middle T-antigen (MT) encoded by polyomavirus induces tumours by mimicking an activated cell surface receptor. A hydrophobic region close to the C-terminus locates MT to the plasma membrane where it initiates oncogenic signalling. HA or FLAG tags added to the C-terminus of MT could be detected on the outside of cells, demonstrating that MT is a transmembrane protein. Addition of a KDEL sequence retained MT in the endoplasmic reticulum, where it failed to transform cells as a consequence of its lack of binding to ShcA, PI3K, and PLC-γ1 despite the phosphorylation of the appropriate binding sites. Additional studies show that MT binding to PP2A is probably required in addition to the TMD for MT to exit the ER and migrate to the plasma membrane. MT on the cell surface is present in discrete clusters that contain phosphorylated ShcA and so represent active signalling complexes. New mutations in the hydrophobic region prevented MT clustering, and also inhibited cell transformation without altering the association of MT with its known binding proteins. Overall, these data, together with previous publications, illustrate that MT associates with signalling proteins at discrete subcellular membrane sites in its maturation pathway. MT binds to PP2A in the cytoplasm, to c-Src at the ER, and to ShcA, PI3K, and PLC-γ1 at subsequent locations en route to the plasma membrane. Formation of a large macromolecular complex in the plasma membrane is probably required for MT signalling. Similar cell surface complexes are observed with activated growth factor receptors, so it is possible that normal and oncogenic signalling from receptors is also dependent upon the assembly of large macromolecular complexes at the cell surface membrane. There was no obvious association of MT clusters with lipid rafts but there was colocalisation with the actin cytoskeleton.
Tätigkeiten und Alltagsgestaltung beim Übertritt in den Ruhestand. Wie der Erhalt in der Gesellschaft gefördert werden kann
Creators: name: Wettstein, Alexandra
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2018

description: Die Gesellschaft wird immer älter, was dazu führt, dass den Menschen nach dem Austritt aus dem Erwerbsleben immer mehr gesunde und aktive Lebensjahre zur Verfügung stehen. Diese wollen und müssen gestaltet werden. In dieser Arbeit wurden neun problemzentrierte Interviews geführt, um der Frage nachzugehen, welche Tätigkeiten Senioren und Seniorinnen nach der Pensionierung ausüben, wie sie ihren Alltag gestalten und welche Unterstützungsmassnahmen in diesem Prozess sinnvoll sein könnten. Die Untersuchung zeigte, dass die Mehrheit der Befragten keine grösseren Schwierigkeiten beim Übergang in den Ruhestand aufwies. Weiter haben die meisten Interviewten nach der Pensionierung keine neuen Tätigkeiten aufgenommen, sondern bereits bestehende Aktivitäten intensiviert und ausgebaut. Probleme beim Übertritt in den Ruhestand scheinen vor allem dann aufzutreten, wenn der Austritt aus dem Berufsleben nicht freiwillig geschieht oder dieser als sehr belastend empfunden wird.
The Complex Network of miRNA and mRNA Target Interactions in Pancreatic Cancer
Creators: name: Frampton, Adam
Publisher: name: Imperial College London
Year: 2014

description: Pancreatic cancer (pancreatic ductal adenocarcinoma, PDAC) is one of the most lethal tumour types world-wide. The majority of patients present late with locally advanced or metastatic disease. Therefore, despite advances in operative techniques, perioperative management and oncological treatments, the overall 5-year survival remains <5%. Determining tumoural factors that contribute towards its aggressive nature may help in identifying novel molecular biomarkers and/or therapeutic targets. MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate target gene expression and are able to act as tumour suppressors or oncogenes. MiRNAs have been extensively profiled and implicated in the initiation and progression of PDAC. Furthermore, there is a possibility of translating miRNAs into clinically useful biomarkers. Here, I developed upon these initial observations and demonstrate that miRNAs can be used to differentiate low risk pancreatic benign cystic tumours (BCTs) from PDAC. We confirmed that these miRNAs regulate the expression of known PDAC oncogenes, and that miR-16, miR-126 and let-7d target BCL2, CRK and KRAS respectively. Next, in order to investigate the main contributors to tumourigenesis, an integrated molecular analysis (miRNA-mRNA) was performed in PDAC. By using a combination of network-based bioinformatics, miR-21, miR-23a and miR-27a were prioritised as important in PDAC progression. We demonstrated that the use of a combination of miRNA inhibitors (against miR-21, miR-23a and miR-27a) in a murine subcutaneous PDAC xenograft model was able to reduce tumour growth, better than oncomiR-21 inhibition alone. BTG2 and NEDD4L were found to be direct targets of the miRNA combination and were established as new candidate tumour suppressors in PDAC. The clinical relevance of this 3 miRNA signature was demonstrated, as high expressors of the combination have poor overall survival after surgical resection, independent of other clinicopathologic factors. Together, these studies identify specific miRNAs as important regulators of PDAC tumourigenesis and their possible use as biomarkers.
Developing a case mix classification for child and adolescent mental health services: the influence of presenting problems, complexity factors and service providers on number of appointments*
Creators: name: Martin, Peter
name: Davies, Roger
name: Macdougall, Amy
name: Ritchie, Benjamin
name: Vostanis, Panos
name: Whale, Andy
name: Wolpert, Miranda
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology

description: Background: Case-mix classification is a focus of international attention in considering how best to manage and fund services, by providing a basis for fairer comparison of resource utilization. Yet there is little evidence of the best ways to establish case mix for child and adolescent mental health services (CAMHS). Aim: To develop a case mix classification for CAMHS that is clinically meaningful and predictive of number of appointments attended and to investigate the influence of presenting problems, context and complexity factors and provider variation. Method: We analysed 4573 completed episodes of outpatient care from 11 English CAMHS. Cluster analysis, regression trees and a conceptual classification based on clinical best practice guidelines were compared regarding their ability to predict number of appointments, using mixed effects negative binomial regression. Results: The conceptual classification is clinically meaningful and did as well as data-driven classifications in accounting for number of appointments. There was little evidence for effects of complexity or context factors, with the possible exception of school attendance problems. Substantial variation in resource provision between providers was not explained well by case mix. Conclusion: The conceptually-derived classification merits further testing and development in the context of collaborative decision making.
The role of macrophage insulin receptor substrate 2 signaling In the regulation of energy homeostasis
Creators: name: Rached, Marie Therese
Publisher: name: Imperial College London
Year: 2014

description: The development of obesity, an imbalance between energy intake and energy expenditure, is associated with disordered cross-talk between the metabolic and immune systems. Insulin resistance, a hallmark of the obese state, is in part a consequence of increased adipose tissue inflammation and is characterized by increased classical macrophage (CAM) infiltration. Yet the genes and molecular mechanism(s) underlying these processes remain poorly understood. Insulin receptor substrate 2 (Irs2) is a critical signaling node through which both insulin and cytokines act to regulate cellular function and may therefore influence macrophage function. To understand the importance of Irs2 in both macrophage biology and energy homeostasis, we have generated mice lacking Irs2 in macrophages (Irs2lysozymeM-/-). When challenged with high fat diet, Irs2lysozymeM-/- mice were resistant to weight gain and fat accumulation in part due to increased energy expenditure. Moreover, they displayed improved glucose homeostasis. At the molecular level, there was decreased adipose tissue expression of inflammatory markers (CAM) that might explain the improved insulin sensitivity. Additionally, there was increased brown adipose tissue expression of thermogenic markers which may underpin the increased energy expenditure. mRNA sequencing analysis of bone marrow-derived macrophages (BMDM) treated with lipopolysaccharides (LPS) revealed that inflammatory signaling pathways, including the nucleotide-binding-oligomerization domain (NOD)-like receptor and the toll-like receptor signaling pathways were down-regulated in the Irs2lysozymeM-/- BMDM compared to control BMDM. This analysis also revealed that targets of Krüppel-like factor 4 (KLF4), a transcription factor implicated in macrophage polarization, were up-regulated in LPS-treated Irs2lysozymeM-/- BMDM. Unbiased metabolomics approach also revealed that the levels of secreted citrulline, a by-product of nitric oxide synthesis and a CAM marker, are reduced in LPS- treated Irs2lysozymeM-/- BMDM. These studies implicate a novel role for macrophage Irs2 in energy homeostasis regulation and identify potential inflammatory processes that can be targeted to treat obesity and insulin resistance.
FOSSA-Ansatz zum Umgang mit Kindern mit Verhaltensschwierigkeiten
Creators: name: Neuenschwander, Markus
name: Zavery, Alafia
name: Bölsterli, Janine
name: Rösti, Ilona
name: Prieth, Vanessa
Publisher: name: Stiftung Schweizer Zentrum für Heil- und Sonderpädagogik
Year: 2022
Subjects: subject: 370 - Erziehung, Schul- und Bildungswesen

description: Kinder mit Verhaltensschwierigkeiten aus belasteten Familien sind im Bildungssystem benachteiligt. Um die Selbstregulation dieser Kinder in der Familie und in der Schule zu fördern, wurde der FOSSA-Ansatz1 entwickelt. Die Familien und Kinder werden zu Hause unterstützt und gefördert; die Lehrpersonen erhalten eine Weiterbildung und ein Coaching. Sie reflektieren ihre Einstellungen und eignen sich Strategien im Umgang mit einzelnen Kindern, der Klasse und der Zusammenarbeit mit Eltern an. Eine erste Evaluation zeigt, dass die Weiterbildung unter den Lehrpersonen eine hohe Akzeptanz erlangt.
Association of killer cell immunoglobulin-like receptor (KIR) genes and their HLA ligands with susceptibility to Behçet’s‎ disease
Creators: name: H Mohammad-Ebrahim
name: E Kamali-Sarvestani
name: M Mahmoudi
name: M Beigy
name: J Karami
name: N Ahmadzadeh
name: F Shahram
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Objectives: Behçet’s disease (BD) is a systemic inflammatory disorder with remissions and exacerbations. It is thought that defects in the natural killer (NK) cell repertoire may be involved in BD through killer cell immunoglobulin-like receptors (KIRs). This study aimed to evaluate KIR and HLA genes, their interactions in BD patients, and their associations with clinical manifestations. Method: The presence or absence of KIR and HLA alleles and genotypes was analysed by polymerase chain reaction sequence-specific primer on genomic DNA of 397 BD patients and 300 healthy controls. Results: None of the KIR genes showed significant effects on BD susceptibility. HLA-C1Asn80 showed a protective effect against BD, whereas HLA-C2Lys80, HLA-B-Bw4Ile80, HLA-B5, and HLA-B51 were associated with a susceptibility risk for BD. In the combination of KIR and HLA genes, the frequencies of HLA genotypes no. 2, 3, 5, and 8, and inhibitory KIR no. 4 were significantly higher in patients than in controls. The frequencies of KIR genotype no. 3 and HLA genotypes no. 1, 4, 6, 7, and 9 were significantly lower in patients than in controls. There were many associations between KIR and HLA genes with clinical features of BD. Conclusion: Differences in the frequency of HLA genes, KIR–HLA interactions, and genotypes between BD and healthy controls and their associations with clinical manifestations indicate that NK cells are involved in BD pathogenesis. The observed differences indicated an NK cell activity imbalance in BD patients, and suggest a role of the KIR-HLA repertoire in the development of BD.
Freiwilligenarbeit im Kanton Zürich mit Zielgruppe Kinder und Jugendliche. Bestandesaufnahme und Bedarfserhebung
Creators: name: Steiner, Olivier
name: Heeg, Rahel
name: Schmid, Magdalene
Publisher: name: Hochschule für Soziale Arbeit FHNW
Year: 2021
Subjects: subject: 360 - Soziale Probleme, Sozialdienste, Versicherungen

description: Angebote der Kinder- und Jugendförderung werden in erheblichem Umfang durch Freiwillige erbracht. Dies betrifft nicht nur Angebote der (verbandlichen) Kinder- und Jugendarbeit, sondern auch das weite Spektrum im sportlichen, musischen und kulturellen Bereich, welches vielfach von lokal verankerten Vereinen getragen wird. Das Teilprojekt 3 des Projekts «Optimierung der Kinder- und Jugendpolitik im Kanton Zürich» verfolgte das strategische Ziel «Stärkung der Freiwilligenarbeit». Das Teilprojekt analysierte die Freiwilligenarbeit in den Gemeinden und in der Kinder- und Jugendarbeit und leitete daraus Empfehlungen ab, die aufzeigten, welche Programme und Massnahmen geeignet und ggf. erforderlich sind, um zu gewährleisten, dass Freiwilligenarbeit auch in Zukunft geleistet wird.
Genetic and environmental correlates of growth patterns leading to obesity
Creators: name: Das, Shikta
Publisher: name: Imperial College London
Year: 2013

description: The intrauterine period is a vulnerable period of development. Any adverse environment can permanently change the body’s organ structure and function, expressed as an increased disease risk later in life. Studies show that variability in growth patterns in early life is associated with obesity and other cardiovascular diseases in adulthood, but the genetic and environmental determinants of these processes are largely unknown. The main objectives of this study were to identify genetic and environmental pre- and postnatal factors associated with early growth in infancy and childhood and later metabolic outcomes in adulthood from the Northern Finland Birth Cohorts (NFBCs). Several maternal and paternal factors, such as height, smoking, parity and pre-eclampsia, had direct association with faster postnatal height growth, some of which had their association mediated by size-at-birth variables. It was observed that an obesogenic environment in utero and during a child’s growth exerts a ‘programming’ effect on the glucose-insulin axis as well as other cardio-vascular risk factors in adolescence. Moreover, the study shows that Leukocyte Telomere Length (LTL) at 31 years, a marker for aging, is inversely associated with multiple measures of adiposity in both men and women, and that a BMI increase in women from childhood to adulthood is associated with shorter telomeres at age 31. Two new genetic variants in/near SBNO1 and HMGA2 genes are associated with infant head circumference, which may indicate influence of brain growth and neurodevelopment via early life. Variants in/near LEPR-LEPROT, FTO, TFAP2B and GNPDA2 showed an age-dependent association with adiposity in early childhood, while three loci (FTO, TFAP2B and GNPDA2) had their effect on adult adiposity mediated by early growth phenotypes. This study emphasises the clinical importance of early growth markers as they may inform public health policy aimed at improving the pre-pregnancy environment and to monitor childhood growth during the first few years of development.
title: 01_0822
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Characterisation of adherent microbubbles for molecular targeted ultrasound
Creators: name: Casey, Jonathan
Publisher: name: Imperial College London
Year: 2013

description: Molecular imaging is a field of medicine which can offer great potential for both diagnostic and therapeutic purposes. Within this field contrast enhanced ultrasound displays the possibility of making molecular imaging a cost effective viable tool in an increasingly diverse set of clinical situations. One of the current challenges associated with this technique is how one differentiates the signal for adherent microbubbles from those produced by the bulk non-adherent population. The first part of this thesis acoustically examines the response of single microbubbles under the effects of adhesion and compares the response observed with that of the MBs non-adherent counterpart. It was found experimentally that differences could be observed in both the 2nd harmonic signals generation and in the stability over repeated exposure. These differences could be utilised as the basis for discretisation imaging strategies. The second section of this thesis attempts to characterize these differences in terms of current theoretical models. A more comprehensive modelling strategy is utilised for the fitting of increasingly complex theoretical models. Good agreement was found with the outputs of this fitting procedure with previously reported parameters. Further detail could also be observed in the form of various size/resonance effects which have not previously been reported. There was little observed difference between the parameters extracted for the adherent and non-adherent MBs although it was suggested that the effective elasticity of an adherent MB could be elevated in comparison to its non-adherent counterpart in the region of resonance. Efforts will be required to control and account for some of the variability observed in MB response before this can be stated definitively however.
Spectroscopic, electrochemical and X-ray crystallographic properties of a novel palladium(II) complex of thioamide deprotonated di-2-pyridyl ketone thiosemicarbazone (dpktsc-H)−
Creators: name: Bakir, Mohammed
name: Lawrence, Mark A. W.
name: Marhoun Ferhat
name: Conry, Rebecca R.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: The reaction between di-2-pyridyl ketone thiosemicarbazone (dpktsc) and PdCl2(CH3CN)2, generated in situ from the reaction between PdCl2 and CH3CN, gave the unprecedented [Pd2Cl3(κ5-Npy,Nim,S,Npy,Nam-dpktsc-H)]·2CH3CN (1) complex (py = pyridine, im = imine and am = amide). The identity of 1 was confirmed via its elemental analysis and spectroscopic properties. Infrared and 1H-NMR spectra confirmed the coordination of (dpktsc-H)− to the palladium ions. The electronic absorption spectra measured in dmso and dmf and density functional theory (DFT) calculations revealed metal-to-ligand charge-transfer (MLCT), d–d and intra-ligand charge-transfer (ILCT) electronic transitions. X-ray structural analysis on a crystal of [Pd2Cl3(κ5-Npy,Nim,S,Npy,Nam-dpktsc-H)]·H2O (2) grown from dmf solution of 1 confirmed its formulation and showed the solid-state structure contains a web of molecules locked via a network of non-covalent interactions. Electrochemical measurements on 1 in dmf revealed metal- and ligand-based redox processes. In contrast to the electrochemical decomposition of uncoordinated dpktsc, coordinated (dpktsc-H)− in 1 does not undergo electrochemical decomposition. Electrochemical titrations of 1 with p-toluenesulfonic acid monohydrate (p-TSOH) revealed electro-catalytic proton reduction. Over-potential (η) of 180 mV for the H2 evolution was observed and is comparable to several molecular electro-catalysts for proton reduction. Controlled-potential electrolysis confirmed the electro-catalytic proton reduction by the Pd-complex. Electrochemical reactions of CO2 in the presence of 1 exhibited a proton dependence, and metal- and ligand-based electrochemical reaction.
The characterisation of a functional interaction between Ikaros and Foxp1 in pre-B-cells and acute lymphoblastic leukaemia
Creators: name: Bond, Jonathan
Publisher: name: Imperial College London
Year: 2013

description: B-lymphopoiesis is characterised by orderly progression through a series of stages of differentiation, each of which is associated with specific patterns of protein expression and cellular proliferation. These processes require a high degree of regulation by the coordinated action of a series of transcription factors that are critical for appropriate stage-specific gene expression. We describe a novel interaction between Ikaros and Foxp1, two transcription factors that are essential for normal B-lymphopoiesis, and which frequently exhibit abnormal expression in B-lymphoid malignancy. By co-immunoprecipitation, we have demonstrated physical association between the DNA-binding domains of these proteins in vivo, which is recapitulated in a cell-free system in vitro. In functional experiments, ectopic overexpression of Foxp1 by retroviral infection of pre-B-cells resulted in an increased proportion of cells in the G2 phase of the cell cycle. This phenotype was associated with increased transcription of Gpr132, a gene which encodes the G2A protein that is known to induce G2/M cell cycle arrest in mammalian cells. The phenotypic effects of Foxp1 overexpression were abolished by coinfection with Ikaros, which abrogated induction of Gpr132 expression by Foxp1, and caused displacement of Foxp1 from the Gpr132 gene, as shown by chromatin immunoprecipitation. Co-infection of IK6 (an Ikaros isoform which lacks the Foxp1 interaction domain and which is frequently expressed in B-cell acute lymphoblastic leukaemia) had no effect on Gpr132 expression or Foxp1 occupancy of the Gpr132 gene, and failed to abolish the phenotypic effects of Foxp1 overexpression. Our results contribute to a growing understanding of transcription factor interplay during normal lymphopoiesis, and provide mechanistic insights into the roles of Ikaros and Foxp1 in lymphocyte cell cycle homeostasis. In addition, these findings may contribute to the understanding of cell cycle dysregulation and chemotherapeutic resistance that characterise certain subtypes of acute leukaemia that exhibit aberrant expression of these proteins.
Gesundheitsförderung in Start-ups
Creators: name: Stanic, Danijela
Publisher: name: Hochschule für Angewandte Psychologie FHNW
Year: 2022
Subjects: Arbeit und Gesundheit
Betriebliches Gesundheitsmanagement
Gesundheit
Gesundheitsförderung
Start-ups

description: In der vorliegenden Arbeit werden vier Fragestellungen fokussiert, mit denen beantwortet werden soll, auf welchem Wege personelle und finanzielle Investitionen in die Gesundheitsförderung von Start-ups einfliessen. Die Datenerhebung wurde beruhend auf den Praktiken in sieben Betrieben durchgeführt und umfasst einen quantitativen Teil mit Kurzfragebogen sowie einen qualitativen Teil mit Expert*inneninterviews. Der Kurzfragebogen diente als Grundlage für die Interviews. Dabei wurden konkrete Massnahmen, die Entwicklung im Bereich Gesundheitsförderung und die finanziellen und personellen Ressourcen erfragt. Die Ergebnisse weisen in die Richtung, dass diejenigen Start-ups mit einer steigenden Anzahl an Mitarbeitenden vermehrt Themen im Bereich Gesundheitsförderung umsetzten, und auch die finanziellen Mittel steigen. Sie zeigen auch, dass gesundheitsförderliche Massnahmen ohne explizit bereitgestellte personelle und finanzielle Ressourcen möglich sind.