Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits
Creators: name: Lin, Phillip
name: Wagenknecht, Lynne E.
name: Louie, Tin
name: Haiman, Christopher A.
name: Downie, Carolina G.
name: Mercader, Josep M.
name: Scartozzi, Alyssa C.
name: Taylor, Kent D.
name: Spracklen, Cassandra N.
name: Duan, Qing
name: Hai, Yang
name: Bowden, Donald W.
name: Gamazon, Eric R.
name: Emery, Leslie S.
name: Blanco, Estela
name: Wang, Yujie
name: Chen, Hung-Hsin
name: Nousome, Darryl
name: Frankel, Elizabeth G.
name: Morris, Andrew P.
name: Stilp, Adrienne M.
name: Kooperberg, Charles
name: Thameem, Farook
name: Guo, Xiuqing
name: Ipp, Eli
name: Buchanan, Thomas A.
name: Ng, Maggie C. Y.
name: Lehman, Donna M.
name: Goodarzi, Mark O.
name: Landman, Joshua M.
name: Fisher-Hoch, Susan P.
name: Nadler, Jerry L.
name: North, Kari E.
name: Genter, Pauline
name: Sofer, Tamar
name: Wacher-Rodarte, Niels
name: Kandeel, Fouad R.
name: Reiner, Alexander P.
name: McCormick, Joseph B.
name: Rohde, Rebecca
name: Tan, Jingyi
name: Xiang, Anny H.
name: Zhang, Weihua
name: Loos, Ruth J. F.
name: McKean-Cowdin, Roberta
name: Rotter, Jerome I.
name: Raffel, Leslie J.
name: Florez, Jose C.
name: Below, Jennifer E.
name: Fried, Susan K.
name: Hsueh, Willa
name: Chen, Yii-Der Ida
name: Petty, Lauren E.
name: Sandow, Kevin
name: Gahagan, Sheila
name: Sharma, Priya
name: Hanis, Craig L.
name: Zhang, Xinruo
name: Lee, Miryoung
name: Li, Yun
name: Graff, Mariaelisa
name: Nadkarni, Girish N.
name: Tusie-Luna, Teresa
name: Correa-Burrows, Paulina
name: Blangero, John
name: Orozco, Lorena
name: McCarthy, Mark I.
name: Roshani, Rashedeh
name: Preuss, Michael
name: Chambers, John C.
name: Rich, Stephen S.
name: Palmer, Nicholette D.
name: Bottinger, Erwin P.
name: Huerta-Chagoya, Alicia
name: Norris, Jill M.
name: Zhu, Wanying
name: Bertoni, Alain
name: Duggirala, Ravindranath
name: González-Villalpando, Clicerio
name: Highland, Heather M.
name: Varma, Rohit
name: DeFronzo, Ralph A.
name: Mahajan, Anubha
name: Whitsel, Eric A.
name: Cruz, Miguel
name: Boehnke, Michael
name: Gao, Chuan
name: Valladares-Salgado, Adan
name: Roll, Kathryn
name: Sim, Xueling
name: Parra, Esteban J.
name: Burrows, Raquel
Publisher: name: Springer Nature
Year: 2025

description: <p>Here, we present a multi-omics study of type 2 diabetes and quantitative blood lipid and lipoprotein traits conducted to date in Hispanic/Latino populations (nmax&thinsp;=&thinsp;63,184). We conduct a meta-analysis of 16 type 2 diabetes and 19 lipid trait GWAS, identifying 20 genome-wide significant loci for type 2 diabetes, including one novel locus and novel signals at two known loci, based on fine-mapping. We also identify sixty-one genome-wide significant loci across the lipid/lipoprotein traits, including nine novel loci, and novel signals at 19 known loci through fine-mapping. Next, we analyze genetically regulated expression, perform Mendelian randomization, and analyze association with transcriptomic and proteomic measure using multi-omics data from a Hispanic/Latino population. Using this approach, we identify genes linked to type 2 diabetes and lipid/lipoprotein traits, including TMEM205 and NEDD9 for HDL cholesterol, TREH for triglycerides, and ANXA4 for type 2 diabetes.</p>