cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Spectra of Graphs and Closed Distance Magic Labelings
Creators: name: Anholcer, Marcin
name: Cichacz, Sylwia
name: Peterin, Iztok
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05C78, 05C50, 05C76

description: Let $G=(V,E)$ be a graph of order $n$. A closed distance magic labeling of $G$ is a bijection $\ell \colon V(G)\rightarrow \{1,\ldots ,n\}$ for which there exists a positive integer $k$ such that $\sum_{x\in N[v]}\ell (x)=k$ for all $v\in V $, where $N[v]$ is the closed neighborhood of $v$. We consider the closed distance magic graphs in the algebraic context. In particular we analyze the relations between the closed distance magic labelings and the spectra of graphs. These results are then applied to the strong product of graphs with complete graph or cycle and to the circulant graphs. We end with a number theoretic problem whose solution results in another family of closed distance magic graphs somewhat related to the strong product.
Studie zur Wahrnehmung von Personen mit psychischen Erkrankungen
Creators: name: Kruesi, Brigitta
name: Luther, Thea
name: Hermann, Darja
name: Schmoll, Ronja
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences

description: Experimentalpsychologisches Praktikum Gruppe 19 - Soziale Eingebundenheit
Optimal $L_p$-discrepancy bounds for second order digital sequences
Creators: name: Dick, Josef
name: Hinrichs, Aicke
name: Markhasin, Lev
name: Pillichshammer, Friedrich
Publisher: name: arXiv
Year: 2016
Subjects: subject: Number Theory (math.NT)
subject: Functional Analysis (math.FA)
subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 11K06, 11K38

description: The $L_p$-discrepancy is a quantitative measure for the irregularity of distribution modulo one of infinite sequences. In 1986 Proinov proved for all $p>1$ a lower bound for the $L_p$-discrepancy of general infinite sequences in the $d$-dimensional unit cube, but it remained an open question whether this lower bound is best possible in the order of magnitude until recently. In 2014 Dick and Pillichshammer gave a first construction of an infinite sequence whose order of $L_2$-discrepancy matches the lower bound of Proinov. Here we give a complete solution to this problem for all finite $p > 1$. We consider so-called order $2$ digital $(t,d)$-sequences over the finite field with two elements and show that such sequences achieve the optimal order of $L_p$-discrepancy simultaneously for all $p \in (1,\infty)$.
description: A journal requested to split the paper into two parts. This is the first part which contains the results on the $L_p$ discrepancy
Spatially Enabled society
Creators: name: Enemark, Stig
name: Rajabifard, Abbas
Publisher: name: Geoforum Perspektiv
Year: 2012

description: The term ‘spatially enabled society’ describes the emerging cultural and governance revolution offered by pervasive spatial information technologies and spatially equipped citizens. Spatially enabled societies make possible, amongst many other things, sustainable cities,early warning systems e.g. in relation to the global financial crisis, smarter delivery of housing, improved risk management, and better macroeconomic decision making. This article introduces the current international discussion around the evolving concept of ‘spatially enabled society’. The concept is not about managing spatial information - it is about managing information, or governing society, spatially.
description: Geoforum Perspektiv, Vol 10 No 20 (2011): Spatially Enabled Society
Regulation of IL-2 gene expression by Siva and FOXP3 in human T cells
Creators: name: Su, Lishan
name: Hench, Virginia K
Publisher: name: BioMed Central Ltd
Year: 2011

description: Abstract Background Severe autoinflammatory diseases are associated with mutations in the Foxp3 locus in both mice and humans. Foxp3 is required for the development, function, and maintenance of regulatory T cells (Tregs), a subset of CD4 cells that suppress T cell activation and inflammatory processes. Siva is a pro-apoptotic gene that is expressed across a range of tissues, including CD4 T cells. Siva interacts with three tumor necrosis factor receptor (TNFR) family members that are constitutively expressed on Treg cells: CD27, GITR, and OX40. Results Here we report a biophysical interaction between FOXP3 and Siva. We mapped the interaction domains to Siva's C-terminus and to a central region of FOXP3. We showed that Siva repressed IL-2 induction by suppressing IL-2 promoter activity during T cell activation. Siva-1's repressive effect on IL-2 gene expression appears to be mediated by inhibition of NFkappaB, whereas FOXP3 repressed both NFkappaB and NFAT activity. Conclusions In summary, our data suggest that both FOXP3 and Siva function as negative regulators of IL-2 gene expression in Treg cells, via suppression of NFAT by FOXP3 and of NFkappaB by both FOXP3 and Siva. Our work contributes evidence for Siva's role as a T cell signalling mediator in addition to its known pro-apoptotic function. Though further investigations are needed, evidence for the biophysical interaction between FOXP3 and Siva invites the possibility that Siva may be important for proper Treg cell function.
User-centric SDI: Addressing Users Requirements in Third- Generation SDI. The Example of Nature-SDIplus
Creators: name: Hennig, Sabine
name: Belgui, Mariana
Publisher: name: Geoforum Perspektiv
Year: 2013

description: Today, Spatial Data Infrastructures (SDIs) play a key role in spatial information sharing. Since their beginning, SDIs undertook tremendous changes. Product-based (first-generation)models evolved to process-based (second-generation) SDI models. Now we face shift to user-centric, third-generation SDI. Compared to former SDI concepts, the development of third-generation SDI is increasingly driven by users. Within the framework of the EU project Nature-SDIplus, we proposed the application of the interdisciplinary and wide-ranging concept of usability relating to commonly known software development processes as solution to design a user-centric SDI. Based on the results of a Europe-wide user survey, the status quo on nature conservation’s spatial data use was described, user requirements were specified,target user groups of a domain specific SDI were identified, and recommendations made to contribute to user-centric Nature-SDI.
description: Geoforum Perspektiv, Vol 10 No 20 (2011): Spatially Enabled Society
Graph Analysis of Resting State Functional Brain Networks and Associations with Cognitive Outcomes in Survivors of Pediatric Brain Tumors
Creators: name: Semmel, Eric
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Clinical Psychology
subject: Cognitive Neuroscience
subject: Life Sciences
subject: Neuroscience and Neurobiology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: MRI
subject: neuroimaging
subject: neuropsychology

description: Dissertation Project
Towards spatially enabled digital government
Creators: name: Schrøder, Lise
name: Jensen, Bent Hulegaard
Publisher: name: Geoforum Perspektiv
Year: 2012

description: Geographical information (GI) and spatial data infrastructure (SDI) has gained increasing awareness among researchers as well as among executive level managers and politicians. In Europe especially the adoption of the INSPIRE Directive has put spatial data infrastructure on the agendas of the parliaments combined with national e-Government strategies. In Denmark this top-down approach to development of e-Government has been combined with an informal, bottom-up approach with a focus on standardisation, the use of geographical information systems (GIS) and IT-architecture. Though, dealing with the transformation of procedures relating to traditional parts of the Danish public administration lack of awareness regarding place and location as integrative infrastructural elements is still a challenge. This paper will present the Danish case of digitalising the administration of real property rights as means of analysing the potentials as well as challenges in fulfilling the vision of a spatially enabled digital government.
description: Geoforum Perspektiv, Vol 10 No 20 (2011): Spatially Enabled Society
Evaluation of the antitumor effects of c-Myc-Max heterodimerization inhibitor 100258-F4 in ovarian cancer cells
Creators: name: Zhou, Chunxiao
name: Bae-Jump, Victoria
name: Jones, Hannah M
Publisher: name: BioMed Central Ltd
Year: 2014

description: Abstract Epithelial ovarian carcinoma is the most lethal gynecological cancer due to its silent onset and recurrence with resistance to chemotherapy. Overexpression of oncogene c-Myc is one of the most frequently encountered events present in ovarian carcinoma. Disrupting the function of c-Myc and its downstream target genes is a promising strategy for cancer therapy. Our objective was to evaluate the potential effects of small-molecule c-Myc inhibitor, 10058-F4, on ovarian carcinoma cells and the underlying mechanisms by which 10058-F4 exerts its actions. Using MTT assay, colony formation, flow cytometry and Annexin V FITC assays, we found that 10058-F4 significantly inhibited cell proliferation of both SKOV3 and Hey ovarian cancer cells in a dose dependent manner through induction of apoptosis and cell cycle G1 arrest. Treatment with 10058-F4 reduced cellular ATP production and ROS levels in SKOV3 and Hey cells. Consistently, primary cultures of ovarian cancer treated with 10058-F4 showed induction of caspase-3 activity and inhibition of cell proliferation in 15 of 18 cases. The response to 10058-F4 was independent the level of c-Myc protein over-expression in primary cultures of ovarian carcinoma. These novel findings suggest that the growth of ovarian cancer cells is dependent upon c-MYC activity and that targeting c-Myc-Max heterodimerization could be a potential therapeutic strategy for ovarian cancer.
Marine Spatial Data Infrastruktur – hvad er status for en infrastruktur for geografi sk data til søs i Danmark.
Creators: name: Stigsen, Tino Kastbjerg
name: Weber, Michael
name: Hvingel, Line
Publisher: name: Geoforum Perspektiv
Year: 2012

description: En bæredygtig fremtid har stået højt på den politiske dagsorden siden Brundtland rapporten udkom i 1987. Geodata spiller en væsentlig rolle i opfyldelse af dette mål. Med udgangspunkt i geodata kan der skabes en datainfrastruktur, der kan være med til at understøtte den planlægning, administration og generelt det beslutningsgrundlag, der er nødvendige værktøjer for at kunne opnå bæredygtighed i såvel det økonomiske, det sociale og det miljømæssige perspektiv. Sammenhængen udlægges i teori og modeldannelse af blandt andet diskurserne omhandlende Land Administration System (LAS) og Spatially Enabled Society, såvel som i teorier om digital forvaltning (eGovernment). Alle diskurser anerkender vigtigheden af Spatial Data Infrastructure (SDI), og dermed af geodata, som et redskab og katalysator for processen.
description: Geoforum Perspektiv, Vol 10 No 20 (2011): Spatially Enabled Society
"Big Bang'' as a result of first-order phase transition driven by changing scalar curvature in expanding early Universe: "hyperinflation'' scenario
Creators: name: Pashitskii, E. A.
name: Pentegov, V. I.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We suggest that the "Big Bang" may be a result of the first-order phase transition driven by changing scalar curvature of the 4D space-time in expanding cold Universe, filled with nonlinear scalar field $ϕ$ and neutral matter with equation of state $p=ν\varepsilon $ (where $p$ and $\varepsilon $ are pressure and energy density of matter). We consider a Lagrangian for scalar field in curved space-time with nonlinearity $ϕ^{4} $, which along with the quadratic term $-ξR\left|ϕ\right|^{2} $ (where $ξ$ is the interaction constant and $R$ is scalar curvature) contains a term $\sim ξR\left(ϕ+ϕ^{+} \right)$ linear in $ϕ$. Due to this term the condition for the extrema of the potential energy of scalar field is given by a cubic equation. Provided $ν> 1/3$ the scalar curvature $R=[κ(3ν-1)\varepsilon -4Λ]$ (where $κ$ and $Λ$ are Einstein's gravitational and cosmological constants) decreases along with decreasing $\varepsilon $ in the process of the Universe's expansion, and at some critical value $R_{c} < 0$ a first-order phase transition occurs, induced by an "external field" parameter proportional to $R$. Given certain conditions the critical radius of the early Universe at the point of the first-order phase transition may reach arbitrary large values, so this scenario of unrestricted "inflation" of the Universe may be called "hyperinflation". Beyond the point of phase transition the system is rolling down into the potential minimum with the release of the potential energy of scalar field, accompanied by oscillations of its amplitude $ϕ$. The powerful heating of the Universe in the course of attenuation of these oscillations plays the role of "Big Bang".
description: 10 pages, 6 figures; to be published in JETP V.149, No.1 (2016)
Analyse af GIS- baseret borgerinddragelse i danske kommuner
Creators: name: Wøhlk, Rune
name: Danielsen, Simon Kamp
Publisher: name: Geoforum Perspektiv
Year: 2012

description: Der er ikke tidligere udarbejdet en samlet opgørelse over GIS- baseret borgerinddragelse i de danske kommuner. Derfor er det relevant at skabe et overblik over tilstanden af GIS- baseret borgerinddragelse i Danmark uden for det videnskabelige miljø. Denne artikel er baseret på en undersøgelse af udbredelsen og anvendelsen af GIS- baseret borgerinddragelse i de danske kommuner.
description: Geoforum Perspektiv, Vol 11 No 21 (2012): Borgerinddragelse gennem GIS
Discovery potential for $T' \to tZ$ in the trilepton channel at the LHC
Creators: name: Basso, Lorenzo
name: Andrea, Jeremy
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The LHC discovery potential of heavy top partners decaying into a top quark and a $Z$ boson is studied in the trilepton channel at 13 TeV in the single production mode. The clean multilepton final state allows to strongly reduce the background contaminations and to reconstruct the $T'$ mass. We show that a simple cut-and-count analysis probes the parameter space of a simplified model as efficiently as a dedicated multivariate analysis. The trilepton signature finally turns out to be able to probe $T'$ masses up to $2.0$ TeV, when mixing with first generation quarks is included. The reinterpretation in terms of the top-$Z$-quark anomalous coupling is shown.
description: 6 pages, 3 figures. Proceedings for EPS-HEP 2015
Et nyt perspektiv på Perspektiv
Creators: name: Hvingel, Line
Publisher: name: Geoforum Perspektiv
Year: 2012

description: Ind imellem er det meget sundt at lægge et nyt perspektiv på tingene. Det forsøger vi at gøre hvert halve år i forhold til anvendelsen af geografisk information gennem udgivelsen af Perspektiv. Men som noget nyt har vi også lagt et nyt perspektiv på Perspektiv. I 10 år har Perspektiv vist sit værd i forhold til at formidle aktuel og dybdegående viden i relation til Geoforums interessefelt og virkeområder. Rollefordelingen i forhold til geoforum.dk er, at Perspektiv arbejder med større aktiviteter (f.eks. store avancerede og komplekse systemer eller dataproduktioner)og videnskabelige problemstillinger. Det vil Perspektiv også fremover gøre, men der vil ske ændringer i layoutet og opbygningen,og du vil fremover også kunne tilgå Perspektiv gennem en ny online-udgivelse.
description: Geoforum Perspektiv, Vol 11 No 21 (2012): Borgerinddragelse gennem GIS
Example participant report
Creators: name: Moore, Izzy
Publisher: name: Cardiff Metropolitan University
Year: 2023
Subjects: Biomechanics
Rehabilitation
Physiotherapy
Injury prevention

description: This is an example report that we provide to participants following a gait analysis that has been undertaken as part of a research study. This study specifically examined the effect of pelvic floor dysfunction on running biomechanics. We provide participant specific data and provide a lay summary of information to help participants understand the meaning of their data. Data in the example report provided is fictitious and does not represent any participants that participated in our study.
Addendum to "Examining emotional concordance across individuals, contexts, and time"
Creators: name: Toner, Emma
name: Teachman, Bethany
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Clinical Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: clinical psychology
subject: concordance
subject: emotion
subject: emotional concordance
subject: network analysis
subject: social anxiety

description: This is the first addendum to the preregistered project "Revisiting emotional concordance: Examining response patterns across individuals, contexts, and time in a socially anxious sample".
Leder - Borgerinddragelse gennem GIS
Creators: name: Hvingel, Line
Publisher: name: Geoforum Perspektiv
Year: 2012

description: Borgerinddragelse gennem GIS. Eller Public Participation GIS (PP GIS), som den mere akademiske term lyder. Da temaet blev bragt på banen i redaktionen, var det mednogen skepsis - Er der noget nyt i det? Det er der ! Læs videre og bliv klogere på hvorfor.
description: Geoforum Perspektiv, Vol 11 No 21 (2012): Borgerinddragelse gennem GIS
PPGIS på GIS dag, indsamling af mange data på kort tid
Creators: name: Homann, Rune
Publisher: name: Geoforum Perspektiv
Year: 2012

description: På den internationale GIS Dag i 2011, den 3. onsdag i november, var der iværksat et PPGIS (Public Participation GIS) projekt i Vangede ved København. Ideen var at sætte fokus på medborgerskab og faget geografi, da tre 8. klasser fra Munkegårdsskolen i Vangede ved hjælp af håndholdte enheder fik kortlagt graffiti i Vangede. Dermed var der i dette specifikke projekt i første omgang fokus på crowdsourcing og læring, som bare er én lille del af detmeget omfattende begreb PPGIS .
description: Geoforum Perspektiv, Vol 11 No 21 (2012): Borgerinddragelse gennem GIS
Emergent properties of nuclei from ab initio coupled-cluster calculations
Creators: name: Hagen, G.
name: Hjorth-Jensen, M.
name: Jansen, G. R.
name: Papenbrock, T.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Nuclear Theory (nucl-th)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Emergent properties such as nuclear saturation and deformation, and the effects on shell structure due to the proximity of the scattering continuum and particle decay channels are fascinating phenomena in atomic nuclei. In recent years, ab initio approaches to nuclei have taken the first steps towards tackling the computational challenge of describing these phenomena from Hamiltonians with microscopic degrees of freedom. This endeavor is now possible due to ideas from effective field theories, novel optimization strategies for nuclear interactions, ab initio methods exhibiting a soft scaling with mass number, and ever-increasing computational power. This paper reviews some of the recent accomplishments. We also present new results. The recently optimized chiral interaction NNLO$_{\rm sat}$ is shown to provide an accurate description of both charge radii and binding energies in selected light- and medium-mass nuclei up to $^{56}$Ni. We derive an efficient scheme for including continuum effects in coupled-cluster computations of nuclei based on chiral nucleon-nucleon and three-nucleon forces, and present new results for unbound states in the neutron-rich isotopes of oxygen and calcium. The coupling to the continuum impacts the energies of the $J^π= {1/2}^-,{3/2}^-,{7/2}^-,{3/2}^+$ states in $^{17,23,25}$O, and - contrary to naive shell-model expectations - the level ordering of the $J^π= {3/2}^+,{5/2}^+,{9/2}^+$ states in $^{53,55,61}$Ca.
description: Contribution to the Special Physica Scripta Edition - 40 year anniversary - Nobel Prize '75, 27 pages, 7 figures
New tools for public participation in urban planning - a case from Dar es Salaam
Creators: name: Møller-Jensen, Lasse
name: Kiduanga, Juma R
name: Mwanukuzi, Phillip K.
Publisher: name: Geoforum Perspektiv
Year: 2012

description: Public Participation GIS har i efterhånden en del år været foreslået som et relevant redskab for bedre byplanlægning også i de hastigt voksende storbyer i udviklingslandene. Der synes dog ikke at være så mange eksempler på, at PPGIS er velintegreret i planprocessen. Denne artikel handler om nye tekniske muligheder for fælles kortlægning, registrering og deling af geografiske informationer gennem web-baserede services som f.eks. ArcGIS-Online. Vil sådanne kunne tages i anvendelse af berørte borgere og medvirke til en bedre byplanprocess og en forbedret retslig stilling for storbyens marginaliserede grupper, sådan som det har været foreslået?
description: Geoforum Perspektiv, Vol 11 No 21 (2012): Borgerinddragelse gennem GIS
Health systems research in fragile and conflict affected states: a qualitative study of associated challenges
Creators: name: Sheahan, Kate
name: Woodward, Aniek
name: Martineau, Tim
name: Sondorp, Egbert
Publisher: name: BioMed Central
Year: 2017

description: Abstract Background High quality health systems research (HSR) in fragile and conflict-affected states (FCAS) is essential to guiding the policies and programmes that will improve access to health services and, ultimately, health outcomes. Yet, conducting HSR in FCAS is challenging. An understanding of these challenges is essential to tackling them and to supporting research conducted in these complex environments. Led by the Thematic Working Group on Health Systems in FCAS, the primary aim of this study was to develop a research agenda on HSR in FCAS. The secondary aim was to identify the challenges associated with conducting HSR in these contexts. This paper presents these challenges. Methods Guided by a purposely-selected steering group, this qualitative study collected respondents’ perspectives through an online survey (n = 61) and a group discussion at the Third Global Symposium on HSR in September 2014 (n = 11). Respondents with knowledge and/or experience of HSR in FCAS were intentionally recruited. Results Of those ever involved in HSR in FCAS (45/61, 75%), almost all (98%) experienced challenges in conducting their research. Challenges fall under three broad thematic areas: (1) lack of appropriate support; (2) complex local research environment, including access constraints, weak local research capacity, collaboration challenges and lack of trust in the research process; and (3) limited research application, including rapidly outdated findings and lack of engagement with the research process and results. Conclusions This study shows that those familiar with HSR in FCAS face many challenges in gaining support for and in conducting and applying high-quality research. There is a need for more sustainable support, including commitment to and long-term funding of HSR in FCAS; investment in capacity building within FCAS to meet the challenges related to implementation of research in these complex environments; relationship and trust building among stakeholders involved in HSR, particularly between local and international researchers and between researchers and participants; and innovative and flexible approaches to research design and implementation in these insecure and rapidly changing contexts.
Learning Path and Training Materials on "Open Science and Research Data Management in Solid Earth Sciences" - Additional Resources For Trainers And Trainees
Creators: name: Cocco, Massimo
name: Michalek, Jan
name: Nedrebø, Harald
name: Stuebe, Karl Christian
name: Tanlongo, Federica
Publisher: name: Zenodo
Year: 2024
Subjects: subject: Open Science
subject: FAIR principles
subject: Research Data Management
subject: Data science
subject: European Plate Observing System
subject: Solid Earth Sciences
subject: Solid Earth Science
subject: Geosciences
subject: EPOS Data Portal

description: This document is part of Skills4EOSC D5.3: Learning Path and Training Materials on "Open Science Research Data Management in Solid Earth Sciences" package.

It provides set of resources that you can use to better prepare your training, and/or you can provide to learners to learn more on specific aspects and topics mentioned in the course. They include webpages, documents, publications as well as multimedia materials. 

List last updated on August 2024.
HDAC7_Treg_manuscript
Creators: name: Axisa, Pierre-Paul
name: Lucca, Liliana E.
name: R. Lincoln, Matthew
Publisher: name: figshare
Year: 2022
Subjects: subject: Immunology
subject: FOS: Clinical medicine
subject: 110706 Immunogenetics (incl. Genetic Immunology)
subject: 60406 Genetic Immunology
subject: FOS: Biological sciences
subject: 110703 Autoimmunity

description: Analysis scripts along with intermediate data files,, metadata, figures, tables, associated with transcriptomic analyses in HDAC7 Treg manuscript:
 Axisa et al. A Multiple Sclerosis Protective Coding Variant Reveals an Essential Role for HDAC7 in Regulatory T cells
 See README for more details
The role of Volunteered Geographic Information in participatory planning. Examples from Denmark and Finland
Creators: name: Knudsen, Anne-Marie Sanvig
name: Kahila, Maarit
Publisher: name: Geoforum Perspektiv
Year: 2012

description: Due to developments in pervasive computing and the diffusion of digital media technologies, the amount of Volunteered Geographic Information (VGI) is rising rapidly. The paper looks at the potential of applying VGI to a participatory planning context and how this type of information might help capture place-based knowledge and experience. The paper furthermore looks at how VGI might qualify actual planning outputs, an aspect often overlooked in communicative planning. This is done by highlighting two case-studies; one which was carried out in a Danish context, employing volunteered GPS-tracking to capture everyday uses of the urban environment. The second case-study was carried out in Finland, employing SoftGIS as a tool to identify and quantify place-values.
description: Geoforum Perspektiv, Vol 11 No 21 (2012): Borgerinddragelse gennem GIS
Glutathione-S-transferase M1 regulation of diesel exhaust particle-induced pro-inflammatory mediator expression in normal human bronchial epithelial cells
Creators: name: Wu, Weidong
name: Peden, David
Publisher: name: BioMed Central Ltd
Year: 2012

description: Abstract Background Diesel exhaust particles (DEP) contribute substantially to ambient particulate matter (PM) air pollution in urban areas. Inhalation of PM has been associated with increased incidence of lung disease in susceptible populations. We have demonstrated that the glutathione S-transferase M1 (GSTM1) null genotype could aggravate DEP-induced airway inflammation in human subjects. Given the critical role airway epithelial cells play in the pathogenesis of airway inflammation, we established the GSTM1 deficiency condition in primary bronchial epithelial cells from human volunteers with GSTM1 sufficient genotype (GSTM1+) using GSTM1 shRNA to determine whether GSTM1 deficiency could exaggerate DEP-induced expression of interleukin-8 (IL-8) and IL-1β proteins. Furthermore, the mechanisms underlying GSTM1 regulation of DEP-induced IL-8 and IL-1β expression were also investigated. Methods IL-8 and IL-1β protein levels were measured using enzyme-linked immunosorbent assay. GSTM1 deficiency in primary human bronchial epithelial cells was achieved using lentiviral GSTM1 shRNA particles and verified using real-time polymerase chain reaction and immunoblotting. Intracellular reactive oxygen species (ROS) production was evaluated using flow cytometry. Phosphorylation of protein kinases was detected using immunoblotting. Results Exposure of primary human bronchial epithelial cells (GSTM1+) to 25-100 μg/ml DEP for 24 h significantly increased IL-8 and IL-1β protein expression. Knockdown of GSTM1 in these cells further elevated DEP-induced IL-8 and IL-1β expression, implying that GSTM1 deficiency aggravated DEP-induced pro-inflammatory response. DEP stimulation induced the phosphorylation of extracellular signal-regulated kinase (ERK) and Akt, the downstream kinase of phosphoinositide 3-kinase (PI3K), in GSTM1+ bronchial epithelial cells. Pharmacological inhibition of ERK kinase and PI3K activity blocked DEP-induced IL-8 and IL-1β expression. DEP-induced ERK and Akt phosphorylation could be increased by GSTM1 knockdown. In addition, pretreatment of HBEC with the antioxidant N-acetyl cysteine significantly inhibited DEP-induced ERK and Akt phosphorylation, and subsequent IL-8 and IL-1β expression. Conclusion GSTM1 regulates DEP-induced IL-8 and IL-1β expression in primary human bronchial epithelial cells by modulation of ROS, ERK and Akt signaling.
Brugen af Geografiske Informationssystemer til effektundersøgelse af Intelligent Farttilpasning i Danmark
Creators: name: Bolet, Lars
name: Agerholm, Niels
name: Tradisauskas, Nerius
name: Lahrmann, Harry
Publisher: name: Geoforum Perspektiv
Year: 2013

description: Geografiske Informationssystemer er anvendt til at dels at dokumentere, hvilke effekter Intelligent Farttilpasning har på hastighedsoverskridelser, og dels til at undersøge, hvordan disse overskridelser kan præsenteres meningsfuldt i spatiale analyser. Analyser af effekten på kørselsadfærden er foretaget for ti af de deltagende bilister i et nordjysk Intelligent Fartilpasningsforsøg for unge bilister. Hovedresultaterne er, at Intelligent Farttilpasning nedbringer både størrelsen af hastighedsoverskridelser og længden på disse. Uden Intelligent Farttilpasning blev der især kørt for hurtigt på lange lige vejstrækninger, på strækninger, hvor hastighedsgrænsen ændres, samt på strækninger, hvor hastighedsgrænsen var lavere end den normale hastighedsgrænse for denne vejtype. Det blev fundet, at længden af hastighedsoverskridelserne samt metoden Natural Neighbor Interpolation tilsammen var velegnede til at beskrive kørselsadfærden ved spatiale analyser.
description: Geoforum Perspektiv, Vol 11 No 22 (2012): Rygter fra randområderne
De oversete mennesker i randområderne
Creators: name: Staunstrup, Jan Kloster
name: Møller, Jørgen
Publisher: name: Geoforum Perspektiv
Year: 2013

description: I planlægningen og reguleringen af rammevilkårene for livet uden for de større byer, er der mange udfordringer. Vi vil i denne artikel se nærmere på nogle af dem, der knytter sig til den manglende præcision i definition af landdistriktsbegrebet, samt komme med bud på praktiske og teoretisk baserede overvejelser, der kan bidrage til at løse disse.
description: Geoforum Perspektiv, Vol 11 No 22 (2012): Rygter fra randområderne
Fra Smart cities til Rygter fra randområderne
Creators: name: Hvingel, Line
name: Møller, Jørgen
Publisher: name: Geoforum Perspektiv
Year: 2013

description: Fra Smart cities til Rygter fra randområderne Den sidste udgivelse i år var oprindeligt tiltænkt temaet Smart Cities. Begrebet må ligge top 10 over mest hypede ord lige nu, og et google-opslag medfører 127millioner hits. Grunden til den voldsomme interesse i emnet Smart Cities kan blandt andet ses i lyset af, at begrebet er et interdisciplinært emne, der har rødder i byplanlægning,økonomi, mobilitet, miljø, bosætning samt ledelse og forvaltning. Geoforum afholdte i foråret en konference over emnet, og derfor var det af mange grunde relevant og oplagt at sætte emnet som ramme for en udgivelse. Desværre viste det sig sværere end ventet at få artiklerne i hus, og samtidig med dette meldte en gæsteredaktør sig på banen med et forslag. Derfor blev temaet Smart Cities slået af pinden til fordel for en udgivelse om randområderne, hvilket må siges atvære et pudsigt paradoks. Bliv klogere på udkantsdanmark, - og de udfordringer alene afgrænsning heraf rummer - i denne udgivelse
description: Geoforum Perspektiv, Vol 11 No 22 (2012): Rygter fra randområderne
ExoMol molecular line lists: XI The spectrum of nitric acid
Creators: name: Pavlyuchko, Anatoly I.
name: Yurchenko, Sergei N.
name: Tennyson, Jonathan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: Nitric acid is a possible biomarker in the atmospheres of exoplanets. An accurate line list of rotational and rotational-vibrational transitions is computed for nitric acid (HNO$_3$). This line list covers wavelengths longer than 1.42 $μ$m (0 - 7000 cm$^{-1}$) and temperatures up to 500 K. The line list is computed using a hybrid variational -- perturbation theory and empirically tuned potential energy and dipole surfaces. It comprises almost 7 billion transitions involving rotations up to $J=100$. Comparisons with spectra from the HITRAN and PNNL databases demonstrate the accuracy of our calculations. Synthetic spectra of water - nitric acid mixturessuggest that nitric acid has features at 7.5 and 11.25 $μ$m that are capable of providing a clear signature for HNO$_3$; the feature at 11.25 $μ$m is particularly promising. Partition functions plus full line lists of transitions are made available in an electronic form as supplementary data to the article and at www.exomol.com.
description: accepted by MNRAS
Missing baryons traced by the galaxy luminosity density in the large-scale WHIM filaments
Creators: name: Nevalainen, J.
name: Tempel, E.
name: Liivamägi, L. J.
name: Branchini, E.
name: Roncarelli, M.
name: Giocoli, C.
name: Heinämäki, P.
name: Saar, E.
name: Tamm, A.
name: Finoguenov, A.
name: Nurmi, P.
name: Bonamente, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We propose a new approach to the missing baryons problem. Building on the common assumption that the missing baryons are in the form of the Warm Hot Intergalactic Medium (WHIM), we further assumed here that the galaxy luminosity density can be used as a tracer of the WHIM. The latter assumption is supported by our finding of a significant correlation between the WHIM density and the galaxy luminosity density in the hydrodynamical simulations of Cui et al. (2012). We further found that the fraction of the gas mass in the WHIM phase is substantially (by a factor of $\sim$1.6) higher within the large scale galactic filaments, i.e. $\sim$70\%, compared to the average in the full simulation volume of $\sim$0.1\,Gpc$^3$. The relation between the WHIM overdensity and the galaxy luminosity overdensity within the galactic filaments is consistent with linear: $δ_{\rm whim}\,=\,0.7\,\pm\,0.1\,\times\,δ_\mathrm{LD}^{0.9 \pm 0.2}$. We applied our procedure to the line of sight to the blazar H2356-309 and found evidence for the WHIM in correspondence of the Sculptor Wall (z $\sim$0.03 and $\log{N_H}$ = $19.9^{+0.1}_{-0.3}$) and Pisces-Cetus superclusters (z $\sim$0.06 and $\log{N_H}$ = $19.7^{+0.2}_{-0.3}$), in agreement with the redshifts and column densities of the X-ray absorbers identified and studied by Fang et al. (2010) and Zappacosta et al. (2010). This agreement indicates that the galaxy luminosity density and galactic filaments are reliable signposts for the WHIM and that our method is robust in estimating the WHIM density. The signal that we detected cannot originate from the halos of the nearby galaxies since they cannot account for the large WHIM column densities that our method and X-ray analysis consistently find in the Sculptor Wall and Pisces-Cetus superclusters.
description: Accepted for Astronomy & Astrophysics
Common risk factor approach to address socioeconomic inequality in the oral health of preschool children - a prospective cohort study
Creators: name: Do, Loc G
name: Scott, Jane A
name: Thomson, W
name: Ha, Diep H
name: Spencer, A
name: Wong, Ching
name: Devenish, Gemma
name: Rugg-Gunn, Andrew J
name: Stamm, John W
name: Levy, Steven M
Publisher: name: BioMed Central Ltd
Year: 2014

description: Abstract Background Dental caries remains the most prevalent chronic condition in children and a major contributor to poor general health. There is ample evidence of a skewed distribution of oral health, with a small proportion of children in the population bearing the majority of the burden of the disease. This minority group is comprised disproportionately of socioeconomically disadvantaged children. An in-depth longitudinal study is needed to better understand the determinants of child oral health, in order to support effective evidence-based policies and interventions in improving child oral health. The aim of the Study of Mothers’ and Infants’ Life Events Affecting Oral Health (SMILE) project is to identify and evaluate the relative importance and timing of critical factors that shape the oral health of young children and then to seek to evaluate those factors in their inter-relationship with socioeconomic influences. Methods/Design This investigation will apply an observational prospective study design to a cohort of socioeconomically-diverse South Australian newborns and their mothers, intensively following these dyads as the children grow to toddler age. Mothers of newborn children will be invited to participate in the study in the early post-partum period. At enrolment, data will be collected on parental socioeconomic status, mothers’ general and dental health conditions, details of the pregnancy, infant feeding practice and parental health behaviours and practices. Data on diet and feeding practices, oral health behaviours and practices, and dental visiting patterns will be collected at 3, 6, 12 and 24 months of age. When children turn 24-30 months, the children and their mothers/primary care givers will be invited to an oral examination to record oral health status. Anthropometric assessment will also be conducted. Discussion This prospective cohort study will examine a wide range of determinants influencing child oral health and related general conditions such as overweight. It will lead to the evaluation of the inter-relationship among main influences and their relative effect on child oral health. The study findings will provide high level evidence of pathways through which socio-environmental factors impact child oral health. It will also provide an opportunity to examine the relationship between oral health and childhood overweight.
Når geografien er udfordringen
Creators: name: Iversen, Spphie Dige
name: Ravn-Christensen, Cecilie
Publisher: name: Geoforum Perspektiv
Year: 2013

description: I erkendelse af, at der er områder i Danmark, der har brug for en ekstra økonomisk saltvandsindsprøjtning i disse år, valgte den forrige VK-regering at gennemføre en ændring af planloven. Lovændringen blev gennem ført sidste år og er tænkt som en håndsrækning til disse områder. Lovændringen indeholder to centrale dele: 1) definitionen af yderområderne, 2) lempelige bestemmelser for yderområderne. Denne undersøgelse viser, at lovændringen ikke har haft den ønskede virkning. Undersøgelsen er den første analyse af de omdiskuterede planlovsændringer og omfatter de første seks måneders levetid af disse lempeligere regler.
description: Geoforum Perspektiv, Vol 11 No 22 (2012): Rygter fra randområderne
Study protocol: Couples Partnering for Lipid Enhancing Strategies (CouPLES) - a randomized controlled trial
Creators: name: Weinberger, Morris
Publisher: name: BioMed Central Ltd
Year: 2009

description: Abstract Background Almost 50% of Americans have elevated low-density lipoprotein cholesterol (LDL-C). The behaviors required to lower LDL-C levels may be difficult to adhere to if they are inconsistent with spouses' health practices, and, alternatively, may be enhanced by enlisting support from the spouse. This trial extends previous trials by requiring spouse enrollment, teaching spouses how to provide emotional and instrumental support, allowing patients to decide which component of the intervention they would like to receive, and having patients determine their own goals and action plans. Methods Veteran outpatients with above-goal LDL-C (N = 250) and their spouses are randomized, as a couple, to receive printed education materials only or the materials plus an 11-month, nurse-delivered, telephone-based intervention. The intervention contains four modules: medication adherence, diet, exercise, and patient-physician communication. Patients decide which modules they complete and in which order; modules may be repeated or omitted. Telephone calls are to patients and spouses separately and occur monthly. During each patient telephone call, patients' progress is reviewed, and patients create goals and action plans for the upcoming month. During spouse telephone calls, which occur within one week of patient calls, spouses are informed of patients' goals and action plans and devise strategies to increase emotional and instrumental support. The primary outcome is patients' LDL-C, measured at baseline, 6 months, and 11 months. Linear mixed models will be used to test the primary hypothesis that an 11-month, telephone-based patient-spouse intervention will result in a greater reduction in LDL-C as compared to printed education materials. Various process measures, including social support, self-efficacy, medication adherence, dietary behavior, and exercise, are also assessed to explain any change, or lack thereof, in LDL-C. Discussion Given the social context in which self-management occurs, interventions that teach spouses to provide instrumental and emotional support may help patients initiate and adhere to behaviors that lower their LDL-C levels. Moreover, allowing patients to retain autonomy by deciding which behaviors they would like to change and how may improve adherence and clinical outcomes. Trial Registration The ClinicalTrials.gov registration number is NCT00321789.
Energy levels and radiative rates for transitions in Cr-like Co IV and Ni V
Creators: name: Aggarwal, K. M.
name: Bogdanovich, P.
name: Karpuškienė, R.
name: Keenan, F. P.
name: Kisielius, R.
name: Stancalie, V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We report calculations of energy levels and radiative rates ($A$-values) for transitions in Cr-like Co IV and Ni V. The quasi-relativistic Hartree-Fock (QRHF) code is adopted for calculating the data although GRASP (general-purpose relativistic atomic structure package) and flexible atomic code (FAC) have also been employed for comparison purposes. No radiative rates are available in the literature to compare with our results, but our calculated energies are in close agreement with those compiled by NIST for a majority of the levels. However, there are discrepancies for a few levels of up to 3\%. The $A$-values are listed for all significantly contributing E1, E2 and M1 transitions, and the corresponding lifetimes reported, although unfortunately no previous theoretical or experimental results exist to compare with our data.
description: The paper will appear in ADNDT (2016) and in October 2015 on the web
Udkantsdanmark skal kortlægges
Creators: name: Skov, Henrik
Publisher: name: Geoforum Perspektiv
Year: 2013

description: Overordnet set ved vi meget om, hvordan Udkantsdanmark udvikler sig. De unge rejser imod de større byer, ældrebyrden vokser, antallet af offentlige institutioner er lavt, og der er dårlige beskæftigelsesforhold. Derimod ved vi langt mindre om, hvordan udviklingen forholder sig mere lokalt eller på mindre skala i Udkantsdanmark. Nærværende artikel vil diskutere behovet for at se Udkantsdanmark med mere nuancerede briller. Briller, hvor man ikke anskuer Udkantsdanmark som en samlet geografiske enhed, men snarere som en samling af mange mindre områder, der hver især har sin egen udvikling og historie at fortælle.
description: Geoforum Perspektiv, Vol 11 No 22 (2012): Rygter fra randområderne
Identifying single electron charge sensor events using wavelet edge detection
Creators: name: Prance, J. R.
name: Van Bael, B. J.
name: Simmons, C. B.
name: Savage, D. E.
name: Lagally, M. G.
name: Friesen, Mark
name: Coppersmith, S. N.
name: Eriksson, M. A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The operation of solid-state qubits often relies on single-shot readout using a nanoelectronic charge sensor, and the detection of events in a noisy sensor signal is crucial for high fidelity readout of such qubits. The most common detection scheme, comparing the signal to a threshold value, is accurate at low noise levels but is not robust to low-frequency noise and signal drift. We describe an alternative method for identifying charge sensor events using wavelet edge detection. The technique is convenient to use and we show that, with realistic signals and a single tunable parameter, wavelet detection can outperform thresholding and is significantly more tolerant to 1/f and low-frequency noise.
description: 11 pages, 4 figures
Dataene er sluppet løs – frie geografiske data
Creators: name: Bjørn-Møldrup, Mads
name: Colding, Tina Svan
Publisher: name: Geoforum Perspektiv
Year: 2013

description: Som led i den fællesoffentlige digitaliseringsstrategi 2011-2015 blev regeringen og kommunernes landsforening (KL) enige om et grunddataprogram i oktober 2012. Grunddata er de data, der bruges overalt i den offentlige sektor, og som er en vigtig forudsætning for, at myndighederne kan varetage deres opgaver korrekt og effektivt. Eksempelvis informationer om personer, virksomheder, ejendomme og naturarealer.Grunddataprogrammet indeholder en række konkrete forbedringer og tiltag omkring offentligegrunddata. Data skal være af en høj kvalitet, gratis at benytte for alle og på sigt distribueres via en fællesoffentlig "datafordeler". Intentionen er, at grunddata vil understøtte effektivisering af den offentlige sektor og være en kilde til innovation, vækst og nye arbejdspladser i den private sektor.Den1. januar 2013 blev Geodatastyrelsens grunddata, de topografiske data, matrikelkortet og Danmarks Højdemodel, de første grunddata, der frit kunne hentes via Geodatastyrelsens kortforsyning. Denne artikel beskriver tiden op til frie geografiske data, hvad der er sket de første tre måneder, samt hvor vii Geodatastyrelsen er på vej hen i forhold til datafordeleren og samarbejdet med omverdenen.
description: Geoforum Perspektiv, Vol 12 No 23 (2013): Autoritative grunddata
The production of a diphoton resonance via photon-photon fusion
Creators: name: Harland-Lang, L. A.
name: Khoze, V. A.
name: Ryskin, M. G.
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Motivated by the recent LHC observation of an excess of diphoton events around an invariant mass of 750 GeV, we discuss the possibility that this is due to the decay of a new scalar or pseudoscalar resonance dominantly produced via photon-photon fusion. We present a precise calculation of the corresponding photon-photon luminosity in the inclusive and exclusive scenarios, and demonstrate that the theoretical uncertainties associated with these are small. In the inclusive channel, we show how simple cuts on the final state may help to isolate the photon-photon induced cross section from any gluon-gluon or vector boson fusion induced contribution. In the exclusive case, that is where both protons remain intact after the collision, we present a precise cross section evaluation and show how this mode is sensitive to the parity of the object, as well as potential $CP$-violating effects. We also comment on the case of heavy-ion collisions and consider the production of new heavy colourless fermions, which may couple to such a resonance.
description: 27 pages, 5 figures. Version accepted for publication in JHEP