title: ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð²Ð»Ð¸ÑÐ½Ð¸Ñ ÑÐºÐ·Ð¾Ð³ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð³ÐµÐ¼Ð¸Ð½Ð° Ð¸ Ð³ÐµÐ¼Ð°ÑÐ¸Ð½Ð° Ð½Ð° ÑÑÐ¸ÑÑÐ¾ÑÐ¸ÑÑ ÑÐµÐ»Ð¾Ð²ÐµÐºÐ°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Investigation of the effects of exogenous hemin and hemin on human erythrocytes
Creators: name: ÐÐ¸ÑÐ°Ð¹Ð»Ð¾Ð²Ð°, ÐÐ¸Ð°Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2023
Subjects: Ð³ÐµÐ¼Ð¸Ð½
Ð³ÐµÐ¼Ð°ÑÐ¸Ð½
Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´Ð½ÑÐµ Ð³ÐµÐ¼Ð°
ÑÑÐ¸ÑÑÐ¾ÑÐ¸ÑÑ
Ð°Ð»ÑÐ±ÑÐ¼Ð¸Ð½
ÑÑÐµÑÐ¸Ð·Ð°ÑÐ¸Ñ
Ð³ÐµÐ¼Ð¾Ð»Ð¸Ð·
Ð¼ÐµÑÐ¾Ð´ Ð»Ð°Ð·ÐµÑÐ½Ð¾Ð¹ Ð´Ð¸ÑÑÐ°ÐºÑÐ¸Ð¸
ÑÐ¿ÐµÐºÑÑÐ¾ÑÐ¾ÑÐ¾Ð¼ÐµÑÑÐ¸Ñ
hemin
hematin
heme derivatives
erythrocytes
albumin
spherization
hemolysis
laser difraction method
spectrophotometry

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description: The given work is devoted to investigation of the effects of exogenous hemin and hemin on human erythrocytes. Hemin and hematin are oxidized heme derivatives formed in the human organism in malaria, hemorrhagic stroke, gastric ulcer, sickle cell anemia and beta-thalassemia. Erythrocytes are one of the main objects of hemin and hematin action resulting in damage of the erythrocytes membrane and alterations of the cytoskeletal proteins conformation. Using laser diffraction method, it was shown that hemin and hematin induced dose-dependent erythrocyte spherization and hemolysis. The effects of these compounds differed probably because of different liganding. The rates of spherization and hemolysis under the action of hemin were higher than hemin rates, indicating a higher reactivity of this compound. The protective role of albumin against toxic heme derivatives was also shown. Albumin, binding to hemin and hematin, inhibited spherization and hemolysis of erythrocytes. Thus, the obtained data will lead to a better understanding of the mechanisms of action of hemin and hemin on human red blood cells, which further improves treatment strategies for such diseases as malaria, hemorrhagic stroke, gastric ulcer, sickle cell anemia and beta-thalassemia.