Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin
Creators: name: Leraas, Kristen M.
name: Wheeler, David
name: Chen, Zhong
name: Chin, Lynda
name: Pihl, Todd
name: Yang, Tai Hsien Ou
name: Getz, Gad
name: Schultz, Nikolaus
name: Verhaak, Roeland
name: Cline, Melisssa
name: Yuan, Yuan
name: Morton, Donna
name: Cho, Dong Yeon
name: Ju, Zhenlin
name: Gehlenborg, Nils
name: Danilova, Ludmila
name: Zack, Travis
name: Fan, Cheng
name: Wan, Yunhu
name: Han, Yi
name: Helman, Elena
name: Liu, Wenbin
name: Xi, Ruibin
name: Bernard, Brady
name: Lopez-Bigas, Nuria
name: Yung, Alfred K.
name: Broom, Bradley
name: Silva, Grace O.
name: Reid, Jeffrey
name: Bhatt, Ami S.
name: Zhang, Jiashan
name: Yang, Lixing
name: Helsel, Carmen
name: Li, Jun
name: Kahles, Andre
name: Wylie, Todd
name: Luquette, Lovelace J.
name: Guin, Ranabir
name: Abbott, Scott
name: Nguyen, Lam
name: Marra, Marco A.
name: McAllister, Cynthia
name: Lerner, Seth
name: Sipahimalani, Payal
name: Leiserson, Max D.M.
name: Byers, Lauren A.
name: Ciriello, Giovanni
name: Brooks, Angela N.
name: Lander, Eric S.
name: Akbani, Rehan
name: Chanock, Stephen
name: Jung, Joonil
name: Gibbs, Richard
name: Ye, Kai
name: Miller, Christopher A.
name: Yoshihara, Kosuke
name: Levine, Douglas A.
name: Gastier-Foster, Julie M.
name: Weisenberger, Daniel J.
name: Liu, Yingchun
name: Van Waes, Carter
name: Hoadley, Katherine A.
name: Hayes, D. Neil
name: Robertson, A. Gordon
name: Gao, Jianjiong
name: Frazer, Scott
name: Haseley, Psalm
name: Ryan, Michael
name: Hamilton, Mark P.
name: Thorsson, Vesteinn
name: Frick, Jessica
name: Taylor, Barry S.
name: McGuire, Sean E.
name: Ramirez, Ricardo
name: Weinstein, John N.
name: Spellman, Paul
name: Dhalla, Noreen
name: Wallis, John W.
name: Lorenzi, Philip L.
name: Tabak, Barbara
name: Drummond, Jennifer
name: Stuart, Joshua M.
name: Chu, Andy
name: Jensen, Mark A.
name: Eley, Greg
name: Zhang, Hailei
name: Lu, Yiling
name: Cleland, James
name: McMichael, Joshua F.
name: Holt, Robert A.
name: Amin, Samirkumar
name: Zhang, Wei
name: Berman, Benjamin P.
name: Doddapaneni, Harsha Vardhan
name: Yao, Jun
name: Anastassiou, Dimitris
name: Hoyle, Alan P.
name: Ma, Singer
name: Tamborero, David
name: Mayo, Michael
name: Seth, Sahil
name: Dooling, David J.
name: Eldred, Jim M.
name: Shmulevich, Ilya
name: Schumacher, Steven E.
name: Pohl, Craig
name: Knijnenburg, Theo
name: Ally, Adrian
name: Shen, Ronglai
name: Eakin, Andrea
name: Bressler, Ryan
name: Balasundaram, Miruna
name: Simons, Janae V.
name: Magrini, Vincent J.
name: Kim, Hoon
name: Bowen, Jay
name: Ellrott, Kyle
name: Chuah, Eric
name: Wu, Chang Jiun
name: Zenklusen, Jean Claude
name: Creighton, Chad J.
name: Shen, Hui
name: Jones, Steven J.M.
name: Zhang, Nianxiang
name: Laird, Peter W.
name: Gunaratne, Preethi
name: Ladanyi, Marc
name: Schmidt, Heather
name: Chun, Hye Jung E.
name: Mieczkowski, Piotr A.
name: Sumer, S. Onur
name: Voet, Doug
name: Xu, Andrew W.
name: Radenbaugh, Amie
name: Parfenov, Michael
name: Auman, J. Todd
name: Yang, Da
name: Van Den Berg, David J.
name: Craft, Brian
name: Baylin, Stephen B.
name: Omberg, Larsson
name: Zhang, Jianhua
name: Pantazi, Angeliki
name: Protopopov, Alexei
name: Tan, Donghui
name: Park, Peter J.
name: Jacobsen, Anders
name: Hadjipanayis, Angela
name: Han, Leng
name: Sougnez, Carrie
name: Wu, Junyuan
name: Fronick, Catrina C.
name: Haussler, David
name: Freeman, Samuel S.
name: Lee, William
name: Dinh, Huyen
name: Paull, Evan
name: McLellan, Michael D.
name: Song, Xingzhi
name: Kahn, Ari
name: Lee, Darlene
name: Tarnuzzer, Roy
name: Zhao, Wei
name: Dees, Nathan D.
name: Schein, Jacqueline E.
name: Goldman, Mary
name: Aksoy, B. Arman
name: Bodenheimer, Tom
name: Pedamallu, Chandra Sekhar
name: Sheth, Margi
name: Tam, Angela
name: Li, Wei
name: Hinoue, Toshinori
name: Koboldt, Daniel C.
name: Wang, Zhining
name: Gabriel, Stacey B.
name: Carter, Scott L.
name: Niu, Beifang
name: Gonzalez-Perez, Abel
name: Wu, Chia Chin
name: Liang, Han
name: DiCara, Daniel
name: Yang, Yang
name: Saksena, Gordon
name: Butterfield, Yaron S.N.
name: Lehmann, Kjong Van
name: Raphael, Benjamin J.
name: Lee, Eunjung
name: Moore, Richard A.
name: Kim, Jaegil
name: Herman, James G.
name: Hirst, Martin
name: Senbabaoglu, Yasin
name: Wise, Lisa
name: Kandoth, Cyriac
name: Edgerton, Mary
name: Benz, Stephen C.
name: Yang, Liming
name: Mose, Lisle E.
name: Wilkerson, Matthew D.
name: Sander, Chris
name: Davidsen, Tanja
name: Benz, Christopher C.
name: Dresdner, Gideon
name: Collisson, Eric A.
name: Veluvolu, Umadevi
name: Varhol, Richard J.
name: Tang, Jiabin
name: Yao, Rong
name: Kucherlapati, Raju
name: Sinha, Rileen
name: Reva, Boris
name: Margolin, Adam A.
name: Cibulskis, Kristian
name: Mahadeshwar, Harshad S.
name: Zmuda, Erik
name: Kane, David W.
name: Kovar, Christie
name: Ren, Xiaojia
name: George, Myra
name: Ramirez, Nilsa C.
name: Herbrich, Shelley M.
name: Swatloski, Teresa
name: Zeng, Dong
name: Stojanov, Petar
name: Triche, Timothy
name: Uzunangelov, Vladislav
name: Liu, Yuexin
name: Dobson, Jason R.
name: Zheng, Siyuan
name: Ding, Li
name: Weinhold, Nils
name: Bootwalla, Moiz S.
name: Reynolds, Sheila M.
name: Yau, Christina
name: Jeffreys, Stuart R.
name: Fulton, Lucinda L.
name: Lee, Semin
name: Muzny, Donna
name: Van't Veer, Laura J.
name: Seidman, Jonathan
name: Chang, Kyle
name: Iype, Lisa
name: Waltman, Peter
name: Casasent, Tod D.
name: Wu, Hsin Ta
name: Buda, Elizabeth
name: Heiman, David I.
name: Stewart, Chip
name: Xia, Zheng
name: Delehaunty, Kim
name: Aldape, Kenneth
name: Sofia, Heidi J.
name: Ley, Timothy J.
name: Cherniack, Andrew D.
name: Mills, Gordon B.
name: Mungall, Andrew J.
name: Rhie, Suhn K.
name: Zhang, Qunyuan
name: Kreisberg, Richard
name: O'Laughlin, Michelle
name: Lin, Ling
name: Felau, Ina
name: Przytycka, Teresa
name: Morgan, Margaret
name: Abbott, Rachel
name: Kanchi, Krishna Latha
name: Wendl, Michael C.
name: Black, Aaron D.
name: Larson, David E.
name: Gross, Benjamin
name: Cho, Juok
name: Kalicki-Veizer, Joelle
name: Bristow, Christopher A.
name: Sun, Yichao
name: Fei, Suzanne
name: Kalra, Divya
name: Meng, Shaowu
name: Ojesina, Akinyemi I.
name: Ng, Sam
name: Salama, Sofie
name: Demchok, John A.
name: Baggerly, Keith A.
name: Dodda, Deepti
name: Soloway, Mathew G.
name: Waring, Scot
name: Fulton, Robert
name: Sharpe, Samantha
name: Harper, Hollie A.
name: Noble, Michael S.
name: Ozenberger, Brad
name: Smith, Scott M.
name: Li, Haiyan I.
name: Thiessen, Nina
name: Zou, Lihua
name: Parker, Joel S.
name: Noushmehr, Houtan
name: Perou, Charles M.
name: Pot, David
name: Lu, Charles
name: Melott, James
name: Wong, Andrew
name: Xi, Liu
name: Carlin, Daniel
name: Staudt, Louis
name: Lewis, Lora
name: Burton, Robert
name: Lichtenberg, Tara M.
name: Wolf, Denise M.
name: Lin, Jake
name: Leinonen, Kalle
name: Zhu, Jing
name: Hamilton, Stanley R.
name: Lin, Pei
name: Miller, Martin L.
name: Roach, Jeffrey
name: Vandin, Fabio
name: Donehower, Lawrence
name: Rätsch, Gunnar
name: Wilson, Richard K.
name: Hirst, Carrie
name: Miller, Michael
name: Birol, Inanc
name: Sokolov, Artem
name: Jones, Corbin D.
name: Wang, Wenyi
name: Mardis, Elaine R.
name: Lawrence, Michael S.
name: Davis, Caleb
name: Balu, Saianand
name: Rovira, Hector
name: Wang, Min
name: Vaske, Charles J.
name: Shi, Yan
name: Su, Xiaoping
name: Santoso, Netty
name: Walker, Jason
name: Kramer, Roger
name: Meyerson, Matthew
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Recent genomic analyses of pathologically-defined tumor types identify “within-a-tissue” disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We performed an integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types, revealing a unified classification into 11 major subtypes. Five subtypes were nearly identical to their tissue-of-origin counterparts, but several distinct cancer types were found to converge into common subtypes. Lung squamous, head & neck, and a subset of bladder cancers coalesced into one subtype typified by TP53 alterations, TP63 amplifications, and high expression of immune and proliferation pathway genes. Of note, bladder cancers split into three pan-cancer subtypes. The multi-platform classification, while correlated with tissue-of-origin, provides independent information for predicting clinical outcomes. All datasets are available for data-mining from a unified resource to support further biological discoveries and insights into novel therapeutic strategies.