cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Use of Internet Technology among Older Adults in Residential Aged Care Facilities: Protocol for a Systematic Review and Meta-Analysis
Creators: name: Pantha, Sandesh
name: Shrestha, Sumina
name: Collier, Janette
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4203
subject: Health services and systems
classificationCode: 4205
subject: Nursing

description: Internet usage may help promote the physical and mental health of older adults living in Residential Aged Care Facilities (RACF). There is little evidence of how these older citizens use internet services. This systematic review aims to explore the trends and factors contributing to internet use among aged care residents. A systematic search will be conducted on nine online databases—MEDLINE, EMBASE, PsycInfo, CINAHL, AgeLine, ProQuest, Web of Science, Scopus, and the Cochrane Library. Two reviewers will independently conduct title and abstract screening, full-text reading, critical appraisal, and data extraction. Any discrepancies will be resolved by consensus. Methodological risk of bias will be assessed using the Effective Public Health Practice Project measure and Joanna Briggs Institute checklist. We will report a narrative synthesis of the evidence. Information on factors contributing to internet use and their strength of association will be reported. If feasible, we will undertake a meta-analysis and meta-synthesis. Our review will provide information on the factors predicting internet use among older adults in residential aged care facilities. The evidence from this review will help to formulate further research objectives and, potentially, to design an intervention to trial internet access for these groups. (Protocol Registration: PROSPERO-CRD 42020161227).
Deutsche Wortfeldetymologie in europäischem Kontext – Wortfeldforschung und Bedeutungswandel
Creators: name: Ertel, Ulrike
name: Eckart, Thomas
name: Irslinger, Britta
name: Rains, Christine
name: Wegerhoff, Stefan
Publisher: name: Zenodo
Year: 2025

description: Das Projekt „Deutsche Wortfeldetymologie in europäischem Kontext – Der Mensch in Natur und Kultur“ (DWEE) untersucht semantischen Wandel und erarbeitet dazu Etymologien sowie eine strukturierte Organisation von Teilen des deutschen Wortschatzes basierend auf Wortfeldern unter Berücksichtigung der sprachhistorischen Schichtungen.

Die DWEE-Wortfelder sind nach Substantiven und in einer projektspezifischen Taxonomie geordnet; die einzelnen Lemmata werden ausgehend von der Gegenwartssprache über die älteren deutschen Sprachstufen bis hin zum Althochdeutschen analysiert. Dabei werden semantische Bestimmungen, stilistische Bewertungen sowie räumliche, zeitliche, fachliche und fachsprachliche Zuordnungen vorgenommen.

Das Projekt strukturiert seine Datenbasis in Form von Artikeln und den eigentlichen Etymologien. Artikel dienen dabei der Übersicht über die einzelnen Wortfelder. Zur verbesserten strukturellen Übersicht wurde eigens eine Taxonomie entwickelt, anhand derer die Wortfeldkategorien, jeweils in einem eigenen Printband vorgestellt, in logischer Struktur gegliedert sind. Die bisher veröffentlichten Teil-Wortfelder umfassen die Themen Körper, Alltag, Gesellschaft, Ethik, Religion, Recht und Wirtschaft.

Anhand der Etymologien wird der historische Sprachverlauf eines Wortes deutlich, sie beleuchten Wortherkunft und -bedeutung und helfen dabei zu verstehen, wann ein Wort sich wie und durch welche Einflüsse in Struktur und Bedeutung gewandelt hat. Dabei untersucht DWEE, wie Sprache nicht nur durch den Menschen in stetiger physischer geographischer Bewegung ist, sondern auch innerhalb der Kognition des Menschen Wanderungsphänomene durchläuft. Europäismen der Gegenwartssprache verdeutlichen diesen Umstand.
Marine Organic Carbon Atlas: why do we need it and what does it take to make one?
Creators: name: Palacz, Artur Piotr
name: GRIGORATOU, MARIA
name: Jónasdóttir, Sigrun H.
name: Koski, Marja
name: Kuliński, Karol
name: Nordlund, Lina Mtwana
name: Telszewski, Maciej
name: Visser, Andre
Publisher: name: Zenodo
Year: 2024

description: Significant knowledge gaps remain regarding our ability to understand and forecast future changes in marine carbon cycling. The changing role of biological processes in the uptake and sequestration of carbon from the atmosphere has been identified as a major challenge for the next decade of ocean carbon research. Here we will present a vision and preliminary steps towards creating a Marine Organic Carbon Atlas (MOCA) which aims to consistently and regularly map and assess changes in organic carbon stocks and fluxes based on products and in formats co-designed by a broad spectrum of anticipated users. Inspired by the science and policy impact of existing inorganic carbon data and model products (e.g. Surface Ocean CO2 Atlas, Surface Ocean CO2 Mapping) and drawing lessons from past marine ecosystem model and data atlases (e.g. MAREDAT), MOCA is meant to encompass existing and novel data products which integrate a myriad of biological and biogeochemical measurements and model approaches related to Essential Ocean Variables across the pelagic and benthic ecosystems. We will present examples of specific data product requirements, with a focus on those advancing the capacity to model ocean carbon sequestration, and introduce plans for first demonstrations in the Arctic Ocean and the Baltic Sea as part of upcoming EU projects. Moreover, we will discuss key step changes which the observing and modelling communities need to jointly adopt in order to create MOCA as an element of the Digital Twin of the Ocean.
White lupin (Lupinus albus L.) exposed to elevated atmospheric CO2 requires additional phosphorus for N2 fixation
Creators: name: O'Sullivan, James
name: Jin, Jian
name: Tang, Caixian
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 30
subject: Agricultural, veterinary and food sciences
classificationCode: 3004
subject: Crop and pasture production
classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3103
subject: Ecology
classificationCode: 3108
subject: Plant biology
classificationCode: 41
subject: Environmental sciences

description: Purpose: The steady rise of atmospheric CO2 concentrations enhances symbiotic N2 fixation and plant growth. However, it is largely unknown whether more P is required to enhance N2 fixation under elevated CO2. We examined if plants under elevated CO2 require more P to support enhanced N2 fixation. Methods: White lupin (Lupinus albus L. cv. Kiev) was grown in nutrient solution under ambient (380 ppm) and elevated (700 ppm) CO2 levels at 0, 2, 5, 12, 25 and 50 µM P. Nodulation, nodule function, N2 fixation and plant growth were assessed at 4 and 6 weeks post inoculation. Excess cation uptake and proton release were also analysed due to its importance in P acquisition. Results: Elevated CO2 increased the critical P concentration in nutrient solution for N2 fixation, indicating plants under elevated CO2 need to acquire additional P to support greater N2 fixation. Elevated CO2 improved N2 fixation in P-deficient plants by increasing specific nitrogenase activity. Elevated CO2 also enhanced excess cation uptake which increased proton release by roots. Conclusions: As elevated CO2 increased the plant demand for P, it increased the critical P concentration in nutrient solution for N2 fixation, thereby plants require more P to mitigate the effect of P deficiency on N2 fixation. Despite this, elevated CO2 could enhance N2 fixation in P-limiting environments.
Effectiveness of allied health clinical supervision following the implementation of an organisational framework
Creators: name: Gardner, Marcus
name: McKinstry, Carol
name: Perrin, Byron
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4203
subject: Health services and systems
classificationCode: 4205
subject: Nursing
classificationCode: 4206
subject: Public health

description: BACKGROUND: Clinical supervision makes an important contribution to high quality patient care and professional wellbeing for the allied health workforce. However, there is limited research examining the longitudinal implementation of clinical supervision for allied health. The aim of this study was to determine the effectiveness of clinical supervision for allied health at a regional health service and clinicians' perceptions of the implementation of an organisational clinical supervision framework. METHODS: A cross-sectional study was conducted as a phase of an overarching participatory action research study. The Manchester Clinical Supervision Scale (MCSS-26) tool was used to measure clinical supervision effectiveness with additional open-ended questions included to explore the implementation of the clinical supervision framework. MCSS-26 findings were compared with an initial administration of the MCSS-26 5 years earlier. MCSS-26 data (total scores, summed domain and sub-scale scores) were analysed descriptively and reported as mean and standard deviation values. Differences between groups were analysed with independent-samples t-test (t) and one-way between groups ANOVA. RESULTS: There were 125 responses to the survey (response rate 50%). The total MCSS-26 score was 78.5 (S.D. 14.5). The total MCSS-26 score was unchanged compared with the initial administration. There was a statistically significant difference in clinical supervision effectiveness between speech pathology and physiotherapy (F = 2.9, p = 0.03) and higher MCSS-26 scores for participants whose clinical supervisor was a senior clinician and those who chose their clinical supervisor. Seventy percent of participants perceived that the organisation's clinical supervision framework was useful and provided structure and consistent expectations for clinical supervision. CONCLUSIONS: Clinical supervision was effective for allied health in this regional setting and clinical supervision effectiveness was maintained over a 5 year period. The implementation of an organisational clinical supervision framework may have a positive effect on clinical supervision for some professions.
Greenwashing: In Conversation with a Whistleblower
Creators: name: Fixler, Desiree
name: Eccles, Robert
Publisher: name: University of Notre Dame
Year: 2025
Subjects: classificationCode: 41
subject: Environmental sciences

description: Desiree Fixler, known for whistleblowing on DWS Group's greenwashing, reflects on the scandal's impact and the ongoing regulatory actions against DWS and Deutsche Bank. She discusses the evolving landscape of ESG investing, highlighting improvements in transparency and regulatory enforcement. Fixler critiques the failures of GFANZ and stresses the need for standardized corporate sustainability reporting. She advocates for clearer governance, better board competency, and precise language in sustainable finance.
Presentation in 47th ARO: Coupled influence of tympanic membrane perforation parameters on hearing loss and surgical outcome
Creators: name: Sim, Jae Hoon
Publisher: name: Zenodo
Year: 2024

description: This is a psoter presentation in the 47th Association for Research in Otolaryngology Mid-Winter Meeting, Anaheim, CA, USA, 2024.

The raw data cannot be uploaded because it includes patient data.
Associations between coping strategies and mental health outcomes in autistic adults
Creators: name: Muniandy, Melanie
name: Richdale, Amanda
name: Arnold, SRC
name: Trollor, JN
name: Lawson, Lauren
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 3209
subject: Neurosciences
subject: FOS: Clinical medicine
classificationCode: 52
subject: Psychology
subject: FOS: Psychology
classificationCode: 5201
subject: Applied and developmental psychology
classificationCode: 5203
subject: Clinical and health psychology

description: Compared to the general population, mental health difficulties are commonly reported in autistic adults. However, the ways in which coping strategies are associated with mental health and well-being in this population remain unknown. Further, we do not know if, and if so, how these associations might differ to that of non-autistic adults. In this study, we hypothesized that in both our autistic (N = 255) and non-autistic (N = 165) adult samples, disengagement coping strategies (e.g., denial) would relate to poorer mental health and well-being, while engagement coping strategies (e.g., problem solving) would relate to better mental health and well-being. Regression analyses revealed that higher use of disengagement coping strategies was significantly associated with higher levels of anxiety and depression, and lower levels of well-being in both samples. In contrast, increased use of engagement coping strategies was associated with better well-being, but only in the autistic sample. Our results contribute to the characterization of negative and positive mental health outcomes in autistic adults from a coping perspective, with potential to offer novel information regarding coping strategies to consider when addressing support options for mental health difficulties in the autistic adult population. Lay Summary: Mental health conditions (such as anxiety and depression) and poor well-being are commonly reported in autistic adults. Research suggests that how one copes with stress is associated with one's mental health and well-being. However, we have little information about how coping strategies relate to the mental health of autistic adults, and whether this might be different in non-autistic adults. In this study, we examined the relationship between coping strategies and mental health in a large group of autistic individuals aged 15–80 years. We then compared this with similar aged non-autistic individuals. We found that in both the autistic and non-autistic individuals, using more disengagement coping strategies (such as being in denial, blaming oneself) was related to poorer mental health and well-being. Additionally, using more engagement coping strategies (such as problem solving, acceptance) was related to better mental health and well-being, but only in the autistic individuals. These results can help inform support services, as they highlight the coping strategies that may need to be focused on (i.e., developing engagement coping strategies and reducing disengagement coping strategies) in order to better support the mental health of autistic individuals.
Supplementary materials for “The association between plasma fatty acids and risk of lung cancer: a prospective cohort study of the UK Biobank”
Creators: name: Huang, Jianv
name: Li, Jiacong
name: He, Lu
name: Miao, Junyan
name: Zhu, Meng
name: Dai, Juncheng
name: Jin, Guangfu
name: Ma, Hongxia
name: Hang, Dong
name: Shen, Hongbin
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 420699
subject: Public health not elsewhere classified

description: Context: Fatty acids (FAs) have emerged as significant contributors to tumorigenesis, yet prospective evidence regarding their specific effects on lung cancer risk remains scarce.Objective: To investigate the association between plasma FAs and lung cancer incidence, as well as a potential modification effect of genetic susceptibility on lung cancer risk.Methods: A cohort study was conducted involving 112,547 cancer-free participants from the UK Biobank, with measurements of plasma FAs, including saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), and polyunsaturated fatty acids (PUFAs) at baseline (2006-2010). Cox regression models were employed to assess lung cancer risk according to plasma FA quartiles or 1-SD increment. Furthermore, interaction between plasma FAs and polygenic risk score (PRS) was evaluated using an additive model.Results: Over an average 10.9-year follow-up, 1122 lung cancer cases occurred. After multivariable adjustment, MUFAs were positively associated with lung cancer risk (hazard ratio [HR] per 1-SD = 1.32, 95% confidence interval [CI]: 1.13-1.54). In contrast, PUFAs, particularly n-3 PUFAs, n-6 PUFAs, docosahexaenoic acid, and linoleic acid, were associated with a lower risk of lung cancer, with HRs ranging from 0.79 (95% CI: 0.72-0.87) to 0.89 (95% CI: 0.83-0.95). SFAs were not significantly associated with lung cancer risk. Moreover, we observed an additive interaction between plasma PUFAs and genetic risk. Individuals with a high genetic risk and the lowest quartile of plasma PUFAs had the highest risk of lung cancer (HR = 2.20, 95% CI: 1.43-3.38).Conclusion: Our findings suggest that plasma PUFAs may serve as protective factors, while MUFAs represent risk factors for lung cancer, offering novel insights into lung cancer carcinogenesis and prevention.
A Multi-Faceted Strategy for Evidence Translation Reduces Healthcare Waiting Time: A Mixed Methods Study Using the RE-AIM Framework
Creators: name: Harding, Katherine
name: Lewis, Annie
name: Snowdon, David
name: Kent, Bridie
name: Taylor, Nicholas
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4203
subject: Health services and systems
classificationCode: 46
subject: Information and computing sciences

description: Background: Waiting lists are often thought to be inevitable in healthcare, but strategies that address patient flow by reducing complexity, combining triage with initial management, and/or actively managing the relationship between supply and demand can work. One such model, Specific Timely Appointments for Triage (STAT), brings these elements together and has been found in multiple trials to reduce waiting times by 30-40%. The next challenge is to translate this knowledge into practice. Method: A multi-faceted knowledge translation strategy, including workshops, resources, dissemination of research findings and a community of practice (CoP) was implemented. A mixed methods evaluation of the strategy was conducted based on the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) framework, drawing on an internal database and a survey of workshop and CoP participants. Results: Demonstrating reach, at July 2020 an internal database held details of 342 clinicians and managers from 64 health services who had participated in the workshop program (n = 308) and/or elected to join an online CoP (n = 227). 40 of 69 (58%) respondents to a survey of this population reported they had adopted the model, with some providing data demonstrating that the STAT model had been efficacious in reducing waiting time. Perceived barriers to implementation included an overwhelming existing waiting list, an imbalance between supply and demand and lack of resources. Conclusion: There is high quality evidence from trials that STAT reduces waiting time. Using the RE-AIM framework, this evaluation of a translation strategy demonstrates uptake of evidence to reduce waiting time in health services.
Towards MerMEId 2.0
Creators: name: Stadler, Peter
name: Siam, Omar
name: Bue, Margrethe Støkken
name: Gubsch, Clemens
name: Lewis, David
name: Page, Kevin
name: Geertinger, Axel Teich
name: Lundberg, Sigfrid
name: Neumann, Joshua
name: Jettka, Daniel
name: Wawilow, Anastasia
name: Abraham, Zsofia Karolina
name: Schopper, Daniel
Publisher: name: Zenodo
Year: 2022
Subjects: Software
Metadata
Music encoding
MEI
Community project
Music Encoding Conference

description: This poster has been presented at the Music Encoding Conference 2022 at Dalhousie University, Halifax, Canada. It shows the history of MerMEId from its beginning in 2009 until 2022. The “Metadata Editor and Repository for MEI Data” (MerMEId) is a web based tool to capture and enrich data in the MEI header. The tool was originally developed by Axel Teich Geertinger and Sigfrid Lundberg at the “Danish Centre for Music Editing” for their own work on the thematic-bibliographic catalogues of works of Carl Nielsen, Johann Peter Emilius Hartmann, Johann Adolph Scheibe, and Niels W. Gade (Teich Geertinger & Pugin, 2011; Teich Geertinger & Lundberg, 2015). From the beginning—around 2009—the development of the MerMEId was tightly connected to the evolvement of the MEI standard and the editor was presented at numerous occasions. For 2022 the release of MerMEId 2.0 is planned, introducing new features which were implemented in a community effort. Teich Geertinger, A., & Pugin, L. (2011). MEI for bridging the gap between music cataloguing and digital critical edition. In Die Tonkunst, 5 (3), 289–294. Teich Geertinger, A., & Lundberg, S. (2015). MerMEId: Creating Thematic Catalogues Using MEI Metadata. In Roland, P., & Kepper, J. (Eds.), Music Encoding Conference Proceedings 2013 and 2014. Bavarian State Library (BSB), 122–126. URN: http://nbn-resolving.de/urn:nbn:de:bvb:12-babs2-0000007812.
A Multi-Faceted Strategy for Evidence Translation Reduces Healthcare Waiting Time: A Mixed Methods Study Using the RE-AIM Framework
Creators: name: Harding, Katherine
name: Lewis, Annie K
name: Snowdon, David A
name: Kent, Bridie
name: Taylor, Nicholas
Publisher: name: La Trobe
Year: 2022

description: Background: Waiting lists are often thought to be inevitable in healthcare, but strategies that address patient flow by reducing complexity, combining triage with initial management, and/or actively managing the relationship between supply and demand can work. One such model, Specific Timely Appointments for Triage (STAT), brings these elements together and has been found in multiple trials to reduce waiting times by 30-40%. The next challenge is to translate this knowledge into practice. Method: A multi-faceted knowledge translation strategy, including workshops, resources, dissemination of research findings and a community of practice (CoP) was implemented. A mixed methods evaluation of the strategy was conducted based on the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) framework, drawing on an internal database and a survey of workshop and CoP participants. Results: Demonstrating reach, at July 2020 an internal database held details of 342 clinicians and managers from 64 health services who had participated in the workshop program (n = 308) and/or elected to join an online CoP (n = 227). 40 of 69 (58%) respondents to a survey of this population reported they had adopted the model, with some providing data demonstrating that the STAT model had been efficacious in reducing waiting time. Perceived barriers to implementation included an overwhelming existing waiting list, an imbalance between supply and demand and lack of resources. Conclusion: There is high quality evidence from trials that STAT reduces waiting time. Using the RE-AIM framework, this evaluation of a translation strategy demonstrates uptake of evidence to reduce waiting time in health services.
Neurotransmitters of sleep and wakefulness in flatworms.
Creators: name: Omond, Shauni
name: Hale, Matthew
name: Lesku, John
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3214
subject: Pharmacology and pharmaceutical sciences
classificationCode: 52
subject: Psychology
subject: FOS: Psychology

description: Note that a correction has been published: Sleep, Volume 45, Issue 7, July 2022, zsac127, https://doi.org/10.1093/sleep/zsac127 
STUDY OBJECTIVES: Sleep is a prominent behavioral and biochemical state observed in all animals studied, including platyhelminth flatworms. Investigations into the biochemical mechanisms associated with sleep-and wakefulness-are important for understanding how these states are regulated and how that regulation changed with the evolution of new types of animals. Unfortunately, beyond a handful of vertebrates, such studies on invertebrates are rare. METHODS: We investigated the effect of seven neurotransmitters, and one pharmacological compound, that modulate either sleep or wakefulness in mammals, on flatworms (Girardia tigrina). Flatworms were exposed via ingestion and diffusion to four neurotransmitters that promote wakefulness in vertebrates (acetylcholine, dopamine, glutamate, histamine), and three that induce sleep (adenosine, GABA, serotonin) along with the H1 histamine receptor antagonist pyrilamine. Compounds were administered over concentrations spanning three to five orders of magnitude. Flatworms were then transferred to fresh water and video recorded for analysis. RESULTS: Dopamine and histamine decreased the time spent inactive and increased distance traveled, consistent with their wake-promoting effect in vertebrates and fruit flies; pyrilamine increased restfulness and GABA showed a nonsignificant trend towards promoting restfulness in a dose-dependent manner, in agreement with their sleep-inducing effect in vertebrates, fruit flies, and Hydra. Similar to Hydra, acetylcholine, glutamate, and serotonin, but also adenosine, had no apparent effect on flatworm behavior. CONCLUSIONS: These data demonstrate the potential of neurotransmitters to regulate sleep and wakefulness in flatworms and highlight the conserved action of some neurotransmitters across species.
Supplementary document for Realization of an autonomously controllable process for atomic layer deposition and its encapsulation application in flexible organic light-emitting diodes - 6427790.pdf
Creators: name: Wang, Zhenyu
name: Chen, Ziqiang
name: Wang, Jintao
name: Shangguan, Lianchao
name: Fan, Siyu
name: Duan, Yu
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supporting Information
Exploring Telehealth Readiness in a Resource Limited Setting: Digital and Health Literacy among Older People in Rural India (DAHLIA)
Creators: name: Rasekaba, Tshepo
name: Pereira, Pratibha
name: G, Vinaya Rani.
name: Johnson, Riya
name: McKechnie, Rebecca
name: Blackberry, Irene
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4203
subject: Health services and systems

description: An ageing population, disproportionally affecting developing countries, increases demand on healthcare systems. Digital health offers access to healthcare for older people, particularly those residing in rural areas, as is the case for 71% of older adults in India. This research examined technology uptake and digital and health literacy (eHEALS) among a sample of 150 older adults in rural Mysore and Suttur, India. The study utilised mixed-method, with descriptive analysis of quantitative data and thematic analysis of qualitative data. Low rates of digital (11%) and health literacy (3–27% across domains) were identified. Mobile phone ownership was 50%, but very few owned or used a smartphone and less than 10% used the Internet to contact health professionals. Qualitative analysis found low technology usage, driven by limited exposure and confidence in using digital devices. Barriers to usage included poor traditional literacy and physical aspects of ageing like poor vision. Social support from neighbours, family and local primary healthcare staff may enable adoption of digital health. Access to healthcare through digital means among Indian rural older adults needs to consider low rates of both digital and health literacy and leverage the value of support from family and primary healthcare providers.
Grainyhead-like (Grhl) Target Genes in Development and Cancer
Creators: name: Gasperoni, Jemma
name: Fuller, Jarrad
name: Darido, C
name: Wilanowski, T
name: Dworkin, Sebastian
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3101
subject: Biochemistry and cell biology
classificationCode: 3107
subject: Microbiology
classificationCode: 3404
subject: Medicinal and biomolecular chemistry

description: Grainyhead-like (GRHL) factors are essential, highly conserved transcription factors (TFs) that regulate processes common to both natural cellular behaviours during embryogenesis, and de-regulation of growth and survival pathways in cancer. Serving to drive the transcription, and there-fore activation of multiple co-ordinating pathways, the three GRHL family members (GRHL1-3) are a critical conduit for modulating the molecular landscape that guides cellular decision-making processes during proliferation, epithelial-mesenchymal transition (EMT) and migration. Animal models and in vitro approaches harbouring GRHL loss or gain-of-function are key research tools to understanding gene function, which gives confidence that resultant phenotypes and cellular behav-iours may be translatable to humans. Critically, identifying and characterising the target genes to which these factors bind is also essential, as they allow us to discover and understand novel genetic pathways that could ultimately be used as targets for disease diagnosis, drug discovery and therapeutic strategies. GRHL1-3 and their transcriptional targets have been shown to drive comparable cellular processes in Drosophila, C. elegans, zebrafish and mice, and have recently also been implicated in the aetiology and/or progression of a number of human congenital disorders and cancers of epithelial origin. In this review, we will summarise the state of knowledge pertaining to the role of the GRHL family target genes in both development and cancer, primarily through understanding the genetic pathways transcriptionally regulated by these factors across disparate disease contexts.
title: The Descent: Geographical Information System Mapping as a Method of Quantification in Osteoarchaeological and Taphonomic Analysis of Early Neolithic Human Remains from Cave Burials in North-Western England
Creators: name: Warburton, Keziah Claire
Publisher: name: University of Central Lancashire
Year: 2024

description: Caves have long been recognised as an important aspect of Neolithic burial practice and our understanding around such practices has been supported by taphonomic analysis and re-analysis of original excavations. This research aims to assess whether Geographic Information Systems (GIS) can be used as a tool for exploring taphonomy, currently underutilised in human cave assemblages. Through our understanding of taphonomic patterns at an element, body and stratigraphic level, site specific inferences of burial practices can be reconstructed and patterns across cave burials assessed.

Two main sites were selected for analysis, Cave Ha 3 (Yorkshire) and Heaning Wood (Cumbria). Bone fragments were assessed for taphonomic modifications and mapped onto templates of bones in QGIS. This has created visual and quantitative data of changes at a body level. Spatial archive data was examined and taphonomic modifications were geographically referenced in QGIS. This provided information of its distribution, allowing for analysis of the movement of skeletal elements and possible locations of geological processes within the cave system.

Analysis of Cave Ha 3 has highlighted possible burial locations and position of bodies, adding support to earlier narratives. Spatial data for Heaning Wood was less detailed, however analysis has indicated burial sequences. Eight of the nine individuals recovered from Heaning Wood have been radiocarbon dated, showing distinct episodes of burial spanning from the Early Mesolithic through to the Early Bronze Age. The research provides the most comprehensive report on Heaning Wood to date, with radiocarbon dates challenging previous discourse around the absence of Early Neolithic cave burials along the south coast of Cumbria. The Early Mesolithic date also provides support for the reoccupation of Britain occurring in the North West, simultaneous with occupation in the South.

Results suggest that QGIS can provide excellent visualisation of taphonomic modifications, regardless of whether a site has spatial legacy data. It has allowed analysis of intra and inter-body taphonomic changes. For sites that do have context data, QGIS provides a more traditional use, mapping where these modifications have occurred within the cave. This has implications for understanding original deposition, geological processes and the relationship between the buried bodies and cave.
Vision and Visuomotor Performance Following Acute Ischemic Stroke
Creators: name: Wijesundera, Chamini
name: Crewther, Sheila
name: Wijeratne, Kulasekara
name: Vingrys, AJ
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 3209
subject: Neurosciences
subject: FOS: Clinical medicine
classificationCode: 3212
subject: Ophthalmology and optometry
classificationCode: 5202
subject: Biological psychology

description: Background: As measurable sensory and motor deficits are key to the diagnosis of stroke, we investigated the value of objective tablet based vision and visuomotor capacity assessment in acute mild-moderate ischemic stroke (AIS) patients. Methods: Sixty AIS patients (65 ± 14 years, 33 males) without pre-existing visual/neurological disorders and acuity better than 6/12 were tested at their bedside during the first week post-stroke and were compared to 40 controls (64 ± 11 years, 15 males). Visual field sensitivity, quantified as mean deviation (dB) and visual acuity (with and without luminance noise), were tested on MRFn (Melbourne Rapid Field-Neural) iPad application. Visuomotor capacity was assessed with the Lee-Ryan Eye-Hand Coordination (EHC) iPad application using a capacitive stylus for iPad held in the preferred hand.Time to trace 3 shapes and displacement errors (deviations of >3.5 mm from the shape) were recorded. Diagnostic capacity was considered with Receiver Operating Characteristics. Vision test outcomes were correlated with National Institutes of Health Stroke Scale (NIHSS) score at the admission. Results: Of the 60 AIS patients, 58 grasped the iPad stylus in their preferred right hand even though 31 had left hemisphere lesions. Forty-one patients (68%) with better than 6/12 visual acuity (19 right, 19 left hemisphere and 3 multi-territorial lesions) returned significantly abnormal visual fields. The stroke group took significantly longer (AIS: 93.4 ± 60.1 s; Controls: 33.1 ± 11.5 s, p < 0.01) to complete EHC tracing and made larger displacements (AIS: 16,388 ± 36,367 mm; Controls: 2,620 ± 1,359 mm, p < 0.01) although both control and stroke groups made similar numbers of errors. EHC time was not significantly different between participants with R (n = 26, 84.3 ± 55.3 s) and L (n = 31, 101.3 ± 64.7 s) hemisphere lesions. NIHSS scores and EHC measures showed low correlations (Spearman R: −0.15, L: 0.17). ROC analysis of EHC and vision tests found high diagnostic specificity and sensitivity for a fail at EHC time, or visual field, or Acuity-in-noise (sensivity: 93%, specificity: 83%) that shows little relationship to NIHSS scores. Conclusions: EHC time and vision test outcomes provide an easy and rapid bedside measure that complements existing clinical assessments in AIS. The low correlation between visual function, NIHSS scores and lesion site offers an expanded clinical view of changes following stroke.
Better understanding of the scope and nature of LGBTQA+ religious conversion practices will support recovery
Creators: name: Power, Jennifer
name: Jones, Timothy
name: Jones, Tiffany
name: Despott, Nathan
name: Pallotta‐Chiarolli, Maria
name: Anderson, Joel
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences

description: Australian states and territories have recently moved to ban practices aimed at changing or supressing the sexuality or gender identity of lesbian, gay, bisexual, transgender, queer, asexual or gender and sexually diverse (LGBTQA+) people, often referred to as “conversion practices” (Box 1).1-5 This legislative trend mirrors global recognition of the harms caused by conversion practices (Box 1)6-9 and is supported by the 2021 Australian Medical Association’s position statement on LGBTQIA+ health, which calls on state and territory governments to “ban coercive ‘conversion’ practices”.10 The Australian Psychological Society11 and the Royal Australian and New Zealand College of Psychiatrists12 have also issued position statements stating that sexual or gender orientation change efforts of any kind are harmful and are not supported by these organisations. While it is difficult to estimate the number of people affected by conversion practices in Australia, international research has suggested that up to 14% of people who identify as LGBTQA+ have had some exposure to conversion practices.13
Stochastic Deep Networks with Linear competing units for Model-Agnostic Meta-Learning
Creators: name: Kalais, Konstantinos
name: Chatzis, Sotirios
Publisher: name: Zenodo
Year: 2021

description: This post entails the code and few-shot benchmarks Omniglot and Mini-Imagenet, addressed for our accepted to the ICML 2022 paper "Stochastic Deep Networks with Linear competing units for Model-Agnostic Meta-Learning". Abstract: This work addresses meta-learning (ML) by considering deep networks with stochastic local winner-takes-all (LWTA) activations. This type of network units results in sparse representations from each model layer, as the units are organized into blocks where only one unit generates a nonzero output. The main operating principle of the introduced units rely on stochastic principles, as the network performs posterior sampling over competing units to select the winner. Therefore, the proposed networks are explicitly designed to extract input data representations of sparse stochastic nature, as opposed to the currently standard deterministic representation paradigm. Our approach produces state-of-the-art predictive accuracy on few shot image classification and regression experiments, as well as reduced predictive error on an active learning setting; these improvements come with an immensely reduced computational cost.
EDP-convergence for nonlinear fast–slow reaction systems with detailed balance
Creators: name: Mielke, Alexander
name: Peletier, Mark
name: Stephan, Artur
Publisher: name: Humboldt-Universität zu Berlin
Year: 2021
Subjects: subject: reaction system
subject: mass-action kinetics
subject: gradient structure
subject: evolutionary gamma convergence
subject: 510 Mathematik

description: We consider nonlinear reaction systems satisfying mass-action kinetics with slow and fast reactions. It is known that the fast-reaction-rate limit can be described by an ODE with Lagrange multipliers and a set of nonlinear constraints that ask the fast reactions to be in equilibrium. Our aim is to study the limiting gradient structure which is available if the reaction system satisfies the detailed-balance condition. The gradient structure on the set of concentration vectors is given in terms of the relative Boltzmann entropy and a cosh-type dissipation potential. We show that a limiting or effective gradient structure can be rigorously derived via EDP-convergence, i.e. convergence in the sense of the energy-dissipation principle for gradient flows. In general, the effective entropy will no longer be of Boltzmann type and the reactions will no longer satisfy mass-action kinetics.
Better understanding of the scope and nature of LGBTQA+ religious conversion practices will support recovery
Creators: name: Power, Jennifer
name: Jones, Timothy
name: Jones, Tiffany
name: Despott, Nathan
name: Pallotta‐Chiarolli, Maria
name: Anderson, Joel
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 429999
subject: Other health sciences not elsewhere classified
classificationCode: 529999
subject: Other psychology not elsewhere classified

description: No description supplied
Energy conservation characterizes sleep in sharks
Creators: name: Kelly, Michael
name: Collins, Selwyn P
name: Lesku, John
name: Hemmi, Jan M
name: Collin, Shaun
name: Radford, Craig A
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3109
subject: Zoology

description: Sharks represent the earliest group of jawed vertebrates and as such, they may provide original insight for understanding the evolution of sleep in more derived animals. Unfortunately, beyond a single behavioural investigation, very little is known about sleep in these ancient predators. As such, recordings of physiological indicators of sleep in sharks have never been reported. Reduced energy expenditure arising from sustained restfulness and lowered metabolic rate during sleep have given rise to the hypothesis that sleep plays an important role for energy conservation. To determine whether this idea applies also to sharks, we compared metabolic rates of draughtsboard sharks (Cephaloscyllium isabellum) during periods ostensibly thought to be sleep, along with restful and actively swimming sharks across a 24 h period. We also investigated behaviours that often characterize sleep in other animals, including eye closure and postural recumbency, to establish relationships between physiology and behaviour. Overall, lower metabolic rate and a flat body posture reflect sleep in draughtsboard sharks, whereas eye closure is a poorer indication of sleep. Our results support the idea for the conservation of energy as a function of sleep in these basal vertebrates.
Structural Basis of the Avian Influenza NS1 Protein Interactions with the Cell Polarity Regulator Scribble
Creators: name: Javorsky, Airah Joyce
name: Humbert, Patrick
name: Kvansakul, Marc
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3101
subject: Biochemistry and cell biology
classificationCode: 3107
subject: Microbiology

description: Scribble is a highly conserved regulator of cell polarity, a process that enables the generation of asymmetry at the cellular and tissue level in higher organisms. Scribble acts in concert with Disc-large (Dlg) and Lethal-2-giant larvae (Lgl) to form the Scribble polarity complex, and its functional dysregulation is associated with poor prognosis during viral infections. Viruses have been shown to interfere with Scribble by targeting Scribble PDZ domains to subvert the network of interactions that enable normal control of cell polarity via Scribble, as well as the localisation of the Scribble module within the cell. The influenza A virus NS1 protein was shown to bind to human Scribble (SCRIB) via its C-terminal PDZ binding motif (PBM). It was reported that the PBM sequence ESEV is a virulence determinant for influenza A virus H5N1 whilst other sequences, such as ESKV, KSEV and RSKV, demonstrated no affinity towards Scribble. We now show, using isothermal titration calorimetry (ITC), that ESKV and KSEV bind to SCRIB PDZ domains and that ESEV unexpectedly displayed an affinity towards all four PDZs and not just a selected few. We then define the structural basis for the interactions of SCRIB PDZ1 domain with ESEV and ESKV PBM motifs, as well as SCRIB PDZ3 with the ESKV PBM motif. These findings will serve as a platform for understanding the role of Scribble PDZ domains and their interactions with different NS1 PBMs and the mechanisms that mediate cell polarity within the context of the pathogenesis of influenza A virus.
Supplementary document for Strong Interlayer Coupling in p-Te/n-CdSe van der Waals Heterojunction for Self-Powered Photodetectors with Fast Speed and High Responsivity - 6427848.pdf
Creators: name: Hu, Yanjie
name: Song, Xiaohui
name: Jia, Dongliang
name: Su, Wanhan
name: Lv, Xiaojing
name: Li, Lin
name: Li, Xueping
name: Yan, Yong
name: Jiang, Yurong
name: Xia, Congxin
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement 1 for device fabrication, material characterization,Ids-Vds curves,photocurrent response,Table 1
Lipid profile changes induced by glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a systematic review and network meta-analysis
Creators: name: Chae, Yuna
name: Kwon, Sun-Hong
name: Nam, Jin Hyun
name: Kang, Eunsung
name: Im, Jiae
name: Kim, Hyo-Jin
name: Lee, Eui-Kyung
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: This study was conducted to investigate the effects of glucagon-like peptide-1 receptor (GLP-1) agonists on the lipid profiles of patients with type 2 diabetes. We retrieved the data of phase 3 randomized controlled trials on GLP-1 agonists in patients with type 2 diabetes from the PubMed, Embase, and Cochrane library up to 11 February 2024. We extracted % changes in low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol/total cholesterol (T-CHO) and triglycerides levels from baseline. Using Bayesian network meta-analysis, mean differences and 95% credible intervals for lipid changes were estimated as a unit of percentage points (%p) by class. Twenty-six studies covering 22,290 participants were included. The glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 dual agonist showed significant differences in LDL-C (range of mean differences: −11.61 to −6.77%p), triglycerides (−19.94 to −13.31%p), and T-CHO (−7.94 to −5.09%p) levels compared to placebo, insulin, and sodium-glucose co-transporter 2 (SGLT2) inhibitors. The GLP-1 agonist significantly reduced T-CHO (−5.20%p; −6.39%p) and LDL-C (−4.32%p; −8.17%p) levels compared to placebo and SGLT2 inhibitors, respectively. The GIP/GLP-1 dual agonist positively affects the lipid profiles of patients with type 2 diabetes. This may contribute to a lower risk of cardiovascular disease in patients with type 2 diabetes. PROSPERO (CRD42021282668)
Isolation of Stable Borepin Radicals and Anions
Creators: name: Hollister, KK
name: Yang, W
name: Mondol, R
name: Wentz, KE
name: Molino, Andrew
name: Kaur, Aishvaryadeep
name: Dickie, DA
name: Frenking, G
name: Pan, S
name: Wilson, David
name: Gilliard, RJ
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 34
subject: Chemical sciences
subject: FOS: Chemical sciences
classificationCode: 3402
subject: Inorganic chemistry

description: Borepin, a 7-membered boron-containing heterocycle, has become an emerging molecular platform for the development of new materials and optoelectronics. While electron-deficient borepins are well-established, reduced electron-rich species have remained elusive. Herein we report the first isolable, crystalline borepin radical (2 a, 2 b) and anion (3 a, 3 b) complexes, which have been synthesized by potassium graphite (KC8) reduction of cyclic(alkyl)(amino) carbene-dibenzo[b,d]borepin precursors. Borepin radicals and anions have been characterized by EPR or NMR, elemental analysis, X-ray crystallography, and cyclic voltammetry. In addition, the bonding features have been investigated computationally using density functional theory.