cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A Model-Based Approach for Separating the Cochlear Microphonic from the Auditory Nerve Neurophonic in the Ongoing Response Using Electrocochleography
Creators: name: Fontenot, Tatyana E.
name: Fitzpatrick, Douglas C.
name: Giardina, Christopher K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Electrocochleography (ECochG) is a potential clinically valuable technique for predicting speech perception outcomes in cochlear implant (CI) recipients, among other uses. Current analysis is limited by an inability to quantify hair cell and neural contributions which are mixed in the ongoing part of the response to low frequency tones. Here, we used a model based on source properties to account for recorded waveform shapes and to separate the combined signal into its components. The model for the cochlear microphonic (CM) was a sinusoid with parameters for independent saturation of the peaks and the troughs of the responses. The model for the auditory nerve neurophonic (ANN) was the convolution of a unit potential and population cycle histogram with a parameter for spread of excitation. Phases of the ANN and CM were additional parameters. The average cycle from the ongoing response was the input, and adaptive fitting identified CM and ANN parameters that best reproduced the waveform shape. Test datasets were responses recorded from the round windows of CI recipients, from the round window of gerbils before and after application of neurotoxins, and with simulated signals where each parameter could be manipulated in isolation. Waveforms recorded from 284 CI recipients had a variety of morphologies that the model fit with an average r2 of 0.97 ± 0.058 (standard deviation). With simulated signals, small systematic differences between outputs and inputs were seen with some variable combinations, but in general there were limited interactions among the parameters. In gerbils, the CM reported was relatively unaffected by the neurotoxins. In contrast, the ANN was strongly reduced and the reduction was limited to frequencies of 1,000 Hz and lower, consistent with the range of strong neural phase-locking. Across human CI subjects, the ANN contribution was variable, ranging from nearly none to larger than the CM. Development of this model could provide a means to isolate hair cell and neural activity that are mixed in the ongoing response to low-frequency tones. This tool can help characterize the residual physiology across CI subjects, and can be useful in other clinical settings where a description of the cochlear physiology is desirable.
Früh forciertes Spezialistentum oder überlebte Universalbildung?
Creators: name: Nordhofen, Eckhard
Publisher: name: Herder Korrespondenz
Year: 1970

description: Herder Korrespondenz, Bd. 31 Nr. 3 (1977): Herder Korrespondenz, Band 31, Heft 3
Sonnenfleckenzeichnung Nr. 20.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 22.01.1984, 08:45, erstellt von Marco Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1984

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Sonnenfleckenzeichnung Nr. 118.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 23.05.1984, 11:15, erstellt von Marco Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1984

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Sonnenfleckenzeichnung Nr. 137.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 15.06.1984, 08:00, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1984

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Changes in Cerebral Blood Flow during an Alteration in Glycemic State in a Large Non-human Primate (Papio hamadryas sp.)
Creators: name: Andrade, Marcia C.R.
name: Lin, Ai-Ling
name: Kochunov, Peter
name: Fox, Peter T.
name: Higgins, Paul B.
name: Lancaster, Jack L.
name: Voruganti, Venkata S.
name: Mattern, Vicki
name: Comuzzie, Anthony G.
name: Bastarrachea, Raul A.
name: Davis, Michael D.
name: Wang, Danny J.J.
name: Frost, Patrice
name: Wey, Hsiao-Ying
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Changes in cerebral blood flow (CBF) during a hyperglycemic challenge were mapped, using perfusion-weighted MRI, in a group of non-human primates. Seven female baboons were fasted for 16 h prior to 1-h imaging experiment, performed under general anesthesia, that consisted of a 20-min baseline, followed by a bolus infusion of glucose (500 mg/kg). CBF maps were collected every 7 s and blood glucose and insulin levels were sampled at regular intervals. Blood glucose levels rose from 51.3 ± 10.9 to 203.9 ± 38.9 mg/dL and declined to 133.4 ± 22.0 mg/dL, at the end of the experiment. Regional CBF changes consisted of four clusters: cerebral cortex, thalamus, hypothalamus, and mesencephalon. Increases in the hypothalamic blood flow occurred concurrently with the regulatory response to systemic glucose change, whereas CBF declined for other clusters. The return to baseline of hypothalamic blood flow was observed while CBF was still increasing in other brain regions. The spatial pattern of extra-hypothalamic CBF changes was correlated with the patterns of several cerebral networks including the default mode network. These findings suggest that hypothalamic blood flow response to systemic glucose levels can potentially be explained by regulatory activity. The response of extra-hypothalamic clusters followed a different time course and its spatial pattern resembled that of the default-mode network.
Construction of multi-qubit optimal genuine entanglement witnesses
Creators: name: Han, Kyung Hoon
name: Kye, Seung-Hyeok
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences
subject: 81P15, 15A30, 46L05, 46L07

description: We interpret multi-partite genuine entanglement witnesses as simultaneous positivity of various maps arising from them. We apply this result to multi-qubit {\sf X}-shaped Hermitian matrices, and characterize the conditions for them to be genuine entanglement witnesses, in terms of entries. Furthermore, we find all optimal ones among them. They turn out to have the spanning properties, and so they detect non-zero volume set of multi-qubit genuine entanglement. We also characterize decomposability for {\sf X}-shaped entanglement witnesses.
description: 17 pages, to appear in Journal of Physics A: Mathematical and Theoretical
Sonnenfleckenzeichnung Nr. 10.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 11.01.1984, 10:30, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1984

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Intraoperative Electrocochleographic Characteristics of Auditory Neuropathy Spectrum Disorder in Cochlear Implant Subjects
Creators: name: Brown, Kevin D.
name: Roche, Joseph P.
name: Fontenot, Tatyana E.
name: Adunka, Oliver F.
name: Harris, Michael S.
name: Bastian, Zachary J.
name: Riggs, William J.
name: Giardina, Christopher K.
name: Fitzpatrick, Douglas C.
name: Buchman, Craig A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Auditory neuropathy spectrum disorder (ANSD) is characterized by an apparent discrepancy between measures of cochlear and neural function based on auditory brainstem response (ABR) testing. Clinical indicators of ANSD are a present cochlear microphonic (CM) with small or absent wave V. Many identified ANSD patients have speech impairment severe enough that cochlear implantation (CI) is indicated. To better understand the cochleae identified with ANSD that lead to a CI, we performed intraoperative round window electrocochleography (ECochG) to tone bursts in children (n = 167) and adults (n = 163). Magnitudes of the responses to tones of different frequencies were summed to measure the “total response” (ECochG-TR), a metric often dominated by hair cell activity, and auditory nerve activity was estimated visually from the compound action potential (CAP) and auditory nerve neurophonic (ANN) as a ranked “Nerve Score”. Subjects identified as ANSD (45 ears in children, 3 in adults) had higher values of ECochG-TR than adult and pediatric subjects also receiving CIs not identified as ANSD. However, nerve scores of the ANSD group were similar to the other cohorts, although dominated by the ANN to low frequencies more than in the non-ANSD groups. To high frequencies, the common morphology of ANSD cases was a large CM and summating potential, and small or absent CAP. Common morphologies in other groups were either only a CM, or a combination of CM and CAP. These results indicate that responses to high frequencies, derived primarily from hair cells, are the main source of the CM used to evaluate ANSD in the clinical setting. However, the clinical tests do not capture the wide range of neural activity seen to low frequency sounds.
Effect of Primary School-Based Oral Health Program and Oral Behaviors on Dental Caries among 12- and 15-Year-Old Children
Creators: name: Thitasomakul, Songchai
Publisher: name: The Dental Association of Thailand
Year: 2019
Subjects: Caries increment
School-based oral health program
Oral health behaviors

description: Journal of The Dental Association of Thailand, 69, 1, 070-082
Spontaneous symmetry breaking in correlated wave functions
Creators: name: Kaneko, Ryui
name: Tocchio, Luca F.
name: Valentí, Roser
name: Becca, Federico
name: Gros, Claudius
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We show that Jastrow-Slater wave functions, in which a density-density Jastrow factor is applied onto an uncorrelated fermionic state, may possess long-range order even when all symmetries are preserved in the wave function. This fact is mainly related to the presence of a sufficiently strong Jastrow term (also including the case of full Gutzwiller projection, suitable for describing spin models). Selected examples are reported, including the spawning of Néel order and dimerization in spin systems, and the stabilization of charge and orbital order in itinerant electronic systems.
description: 13 pages, 11 figures
The Electrically Evoked Compound Action Potential: From Laboratory to Clinic
Creators: name: He, Shuman
name: Teagle, Holly F.B.
name: Buchman, Craig A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: The electrically evoked compound action potential (eCAP) represents the synchronous firing of a population of electrically stimulated auditory nerve fibers. It can be directly recorded on a surgically exposed nerve trunk in animals or from an intra-cochlear electrode of a cochlear implant. In the past two decades, the eCAP has been widely recorded in both animals and clinical patient populations using different testing paradigms. This paper provides an overview of recording methodologies and response characteristics of the eCAP, as well as its potential applications in research and clinical situations. Relevant studies are reviewed and implications for clinicians are discussed.
Level repulsion exponent $β$ for Many-Body Localization Transitions and for Anderson Localization Transitions via Dyson Brownian Motion
Creators: name: Monthus, Cecile
Publisher: name: arXiv
Year: 2015
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: The generalization of the Dyson Brownian Motion approach of random matrices to Anderson Localization (AL) models [Chalker, Lerner and Smith PRL 77, 554 (1996)] and to Many-Body Localization (MBL) Hamiltonians [Serbyn and Moore arxiv:1508.07293] is revisited to extract the level repulsion exponent $β$, where $β=1$ in the delocalized phase governed by the Wigner-Dyson statistics, $β=0$ in the localized phase governed by the Poisson statistics, and $0 |^2 $ for the same eigenstate $m=n$ and for consecutive eigenstates $m=n+1$. For the Anderson Localization tight-binding Hamiltonian with random on-site energies $h_i$, we find $β=2 Y_{n,n+1}(N)/(Y_{n,n}(N)-Y_{n,n+1}(N)) $ in terms of the Density Correlation matrix $Y_{nm}(N) \equiv \sum_{i=1}^N | < ϕ_n | i> |^2 |  |^2 $ for consecutive eigenstates $m=n+1$, while the diagonal element $m=n$ corresponds to the Inverse Participation Ratio $Y_{nn}(N) \equiv \sum_{i=1}^N | < ϕ_n | i> |^4 $ of the eigenstate $| ϕ_n>$.
description: 22 pages
Sonnenfleckenzeichnung Nr. 74.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 27.03.1984, 07:15, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1984

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Sonnenfleckenzeichnung Nr. 165.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 13.07.1984, 07:15, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1984

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Sonnenfleckenzeichnung Nr. 109.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 11.05.1984, 08:00, erstellt von Marco Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1984

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
UNC-Emory Infant Atlases for Macaque Brain Image Analysis: Postnatal Brain Development through 12 Months
Creators: name: Styner, Martin A.
name: Howell, Brittany
name: Yapuncich, Eva
name: Rumple, Ashley
name: Sanchez, Mar M.
name: Budin, Francois
name: Godfrey, Jodi
name: Shi, Yundi
name: Young, Jeffrey T.
name: Hu, Xiaoping
name: Zhang, Xiaodong
name: Payne, Christa
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Computational anatomical atlases have shown to be of immense value in neuroimaging as they provide age appropriate reference spaces alongside ancillary anatomical information for automated analysis such as subcortical structural definitions, cortical parcellations or white fiber tract regions. Standard workflows in neuroimaging necessitate such atlases to be appropriately selected for the subject population of interest. This is especially of importance in early postnatal brain development, where rapid changes in brain shape and appearance render neuroimaging workflows sensitive to the appropriate atlas choice. We present here a set of novel computation atlases for structural MRI and Diffusion Tensor Imaging as crucial resource for the analysis of MRI data from non-human primate rhesus monkey (Macaca mulatta) data in early postnatal brain development. Forty socially-housed infant macaques were scanned longitudinally at ages 2 weeks, 3, 6, and 12 months in order to create cross-sectional structural and DTI atlases via unbiased atlas building at each of these ages. Probabilistic spatial prior definitions for the major tissue classes were trained on each atlas with expert manual segmentations. In this article we present the development and use of these atlases with publicly available tools, as well as the atlases themselves, which are publicly disseminated to the scientific community.
Increasing JAK/STAT Signaling Function of Infant CD4+ T Cells during the First Year of Life
Creators: name: Hudgens, Michael G.
name: Peter-Wohl, Sigal
name: Rodriguez-Nieves, Jennifer
name: Mollan, Katie R.
name: dela Peña-Ponce, Myra Grace
name: Mengual, Michael
name: Bernhardt, Janice
name: Tuck, Ryan
name: Choudhary, Neelima
name: De Paris, Kristina
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Most infant deaths occur in the first year of life. Yet, our knowledge of immune development during this period is scarce and derived from cord blood (CB) only. To more effectively combat pediatric diseases, a deeper understanding of the kinetics and the factors that regulate the maturation of immune functions in early life is needed. Increased disease susceptibility of infants is generally attributed to T helper 2-biased immune responses. The differentiation of CD4+ T cells along a specific T helper cell lineage is dependent on the pathogen type, and on costimulatory and cytokine signals provided by antigen-presenting cells. Cytokines also regulate many other aspects of the host immune response. Therefore, toward the goal of increasing our knowledge of early immune development, we defined the temporal development of the Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signaling function of CD4+ T cells using cross-sectional blood samples from healthy infants ages 0 (birth) to 14 months. We specifically focused on cytokines important in T cell differentiation (IFN-γ, IL-12, and IL-4) or in T cell survival and expansion (IL-2 and IL-7) in infant CD4+ T cells. Independent of the cytokine tested, JAK/STAT signaling in infant compared to adult CD4+ T cells was impaired at birth, but increased during the first year, with the most pronounced changes occurring in the first 6 months. The relative change in JAK/STAT signaling of infant CD4+ T cells with age was distinct for each cytokine tested. Thus, while about 60% of CB CD4+ T cells could efficiently activate STAT6 in response to IL-4, less than 5% of CB CD4+ T cells were able to activate the JAK/STAT pathway in response to IFN-γ, IL-12 or IL-2. By 4–6 months of age, the activation of the cytokine-specific STAT molecules was comparable to adults in response to IL-4 and IFN-γ, while IL-2- and IL-12-induced STAT activation remained below adult levels even at 1 year. These results suggest that common developmental and cytokine-specific factors regulate the maturation of the JAK/STAT signaling function in CD4+ T cells during the first year of life.
Strong correlation effects in theoretical STM studies of magnetic adatoms
Creators: name: Dang, Hung T.
name: Dias, Manuel dos Santos
name: Liebsch, Ansgar
name: Lounis, Samir
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We present a theoretical study for the scanning tunneling microscopy (STM) spectra of surface-supported magnetic nanostructures, incorporating strong correlation effects. As concrete examples, we study Co and Mn adatoms on the Cu(111) surface, which are expected to represent the opposite limits of the Kondo physics and local moment behavior, using a combination of density functional theory and both quantum Monte Carlo and exact diagonalization impurity solvers. We examine in detail the effects of temperature $T$, correlation strength $U$, and the impurity $d$ electron occupancy $N_d$ on the local density of states. We also study the effective coherence energy scale, i.e., the Kondo temperature $T_K$, which can be extracted from the STM spectra. Theoretical STM spectra are computed as a function of the STM tip position relative to each adatom. Because of the multi-orbital nature of the adatoms, the STM spectra are shown to consist of a complicated superposition of orbital contributions, with different orbital symmetries, self-energies and Kondo temperatures. For the Mn adatom, which is close to half-filling, the STM spectra are featureless near the Fermi level. On the other hand, the quasiparticle peak for Co adatom gives rise to strongly position-dependent Fano line-shapes.
description: 16 pages, 13 figures
Sonnenfleckenzeichnung Nr. 124.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 29.05.1984, 12:30, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1984

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Sonnenfleckenzeichnung Nr. 142.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 20.06.1984, 07:30, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1984

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
BLOCKVOTE: blockchain based voting system
Creators: name: Prof. Balasaheb Gite  , Soni Kumari  , Dipanshu Awandkar , Nilesh Shinde  , Sumit Murkute
Publisher: name: Zenodo
Year: 2023

description: This research paper presents the development of a blockchain-based voting system that
 prioritizes the safety and security of the web application’s front end. To ensure the protection of user
 data during transmission, strong encryption algorithms are employed. The implementation of transport
 layer security (TLS) secures the communication channel, guaranteeing confidentially and data
 integrity.
 The voting system application provides users with a secure platform to cast their votes. Through the
 utilization of blockchain technology, the system maintains transparency, immutability, and integrity
 throughout the voting process. The front end of the web application is designed to be user-friendly,
 facilitating a seamless voting experience for users. The precautions taken to enhance the safety of the
 web application include the utilization of robust encryption algorithms, which safeguard the
 transmission of data between users' devices and the application. The implementation of TLS ensures
 that the communication channel is secure, maintaining the confidentiality and integrity of the
 transmitted information. Overall, this research presents a blockchain-based voting system that
 combines strong encryption techniques and a user-friendly front end to ensure the safety and security
 of the voting process. The system's architecture and precautions are taken to provide a reliable
 platform for voters to participate in elections securely and efficiently.
Sonnenfleckenzeichnung Nr. 42.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 19.02.1984, 10:00, erstellt von Marco Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1984

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Transitioning Pharmacogenomics into the Clinical Setting: Training Future Pharmacists
Creators: name: Wang, Nan
name: McLaughlin, Jacqueline E.
name: Benton, Cristina S.
name: Scolaro, Kelly L.
name: Wiltshire, Tim
name: Frick, Amber
name: Bradley, Courtney L.
name: Suzuki, Oscar T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Pharmacogenomics, once hailed as a futuristic approach to pharmacotherapy, has transitioned to clinical implementation. Although logistic and economic limitations to clinical pharmacogenomics are being superseded by external measures such as preemptive genotyping, implementation by clinicians has met resistance, partly due to a lack of education. Pharmacists, with extensive training in pharmacology and pharmacotherapy and accessibility to patients, are ideally suited to champion clinical pharmacogenomics. This study aimed to analyze the outcomes of an innovative pharmacogenomic teaching approach. Second-year student pharmacists enrolled in a required, 15-week pharmaceutical care lab course in 2015 completed educational activities including lectures and small group work focusing on practical pharmacogenomics. Reflecting the current landscape of direct-to-consumer (DTC) genomic testing, students were offered 23andMe genotyping. Students completed surveys regarding their attitudes and confidence on pharmacogenomics prior to and following the educational intervention. Paired pre- and post-intervention responses were analyzed with McNemar's test for binary comparisons and the Wilcoxon signed-rank test for Likert items. Responses between genotyped and non-genotyped students were analyzed with Fisher's exact test for binary comparisons and the Mann-Whitney U-test for Likert items. Responses were analyzed for all student pharmacists who voluntarily completed the pre-intervention survey (N = 121, 83% response) and for student pharmacists who completed both pre- and post-intervention surveys (N = 39, 27% response). Of those who completed both pre- and post-intervention surveys, 59% obtained genotyping. Student pharmacists demonstrated a significant increase in their knowledge of pharmacogenomic resources (17.9 vs. 56.4%, p < 0.0001) and confidence in applying pharmacogenomic information to manage patients' drug therapy (28.2 vs. 48.7%, p = 0.01), particularly if the student had received genotyping. Student pharmacists understanding of the risks and benefits of using personal genome testing services significantly increased (55.3 vs. 86.8%, p = 0.001) along with agreement that personal genomics would likely play an important role in their future career (47.4 vs. 76.3%, p = 0.01), particularly among students who participated in genotyping. The educational intervention, including personal genotyping, was feasible, and positively enhanced students' reflections, and attitudes toward pharmacogenomics in a professional pharmacy program.
Origin and properties of dual and offset active galactic nuclei in a cosmological simulation at z=2
Creators: name: Steinborn, Lisa K.
name: Dolag, Klaus
name: Comerford, Julia M.
name: Hirschmann, Michaela
name: Remus, Rhea-Silvia
name: Teklu, Adelheid F.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: In the last few years, it became possible to observationally resolve galaxies with two distinct nuclei in their centre. For separations smaller than 10kpc, dual and offset active galactic nuclei (AGN) are distinguished: in dual AGN, both nuclei are active, whereas in offset AGN only one nucleus is active. To study the origin of such AGN pairs, we employ a cosmological, hydrodynamic simulation with a large volume of (182Mpc)^3 from the set of Magneticum Pathfinder Simulations. The simulation self-consistently produces 35 resolved black hole (BH) pairs at redshift z=2, with a comoving distance smaller than 10kpc. 14 of them are offset AGN and nine are dual AGN, resulting in a fraction of (1.2 \pm 0.3)% AGN pairs with respect to the total number of AGN. In this paper, we discuss fundamental differences between the BH and galaxy properties of dual AGN, offset AGN and inactive BH pairs and investigate their different triggering mechanisms. We find that in dual AGN the BHs have similar masses and the corresponding BH from the less massive progenitor galaxy always accretes with a higher Eddington ratio. In contrast, in offset AGN the active BH is typically more massive than its non-active counterpart. Furthermore, dual AGN in general accrete more gas from the intergalactic medium than offset AGN and non-active BH pairs. This highlights that merger events, particularly minor mergers, do not necessarily lead to strong gas inflows and thus, do not always drive strong nuclear activity.
description: 17 pages, 18 figures, accepted for publication in MNRAS, website: http://www.magneticum.org
Sonnenfleckenzeichnung Nr. 200.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 20.08.1984, 08:00, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1984

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Phytoagent Deoxyelephantopin and Its Derivative Inhibit Triple Negative Breast Cancer Cell Activity through ROS-Mediated Exosomal Activity and Protein Functions
Creators: name: Chang, Yong-Qun
name: Lee, Kuo-Hsiung
name: Shyur, Lie-Fen
name: Nakagawa-Goto, Kyoko
name: Shiau, Jeng-Yuan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: A novel plant sesquiterpene lactone derivative, DET derivative (DETD)-35, originating from parental deoxyelephantopin (DET) was previously observed to effectively suppress human triple negative breast cancer (TNBC) MDA-MB-231 cell activity and tumor growth in mice. In this study, the mechanisms underlying the activity of DETD-35 were elucidated. DET and DETD-35 induced reactive oxygen species (ROS) which caused structural damage and dysfunction of mitochondria and increased cytosolic calcium level, subsequently evoking exosome release from the cancer cells. Intriguingly, exosomes induced by both compounds had an atypical function. Cancer cell-derived exosomes commonly show metastatic potential, but upon DET/DETD-35 treatment exosomes showed anti-proliferative activity against MDA-MB-231 cells. Quantitative proteome analysis of TNBC cell-secreted exosomes showed that DET and DETD-35 attenuated the expression of proteins related to cell migration, cell adhesion, and angiogenesis. Furthermore, several exosomal proteins participating in biological mechanisms such as oxidative stress and decrease of transmembrane potential of mitochondria were found deregulated by treatment with either compound. Pretreatment with ROS scavenger, N-acetylcysteine, blockaded DET- or DETD-35-induced oxidative stress and calcium dependent exosome release mechanisms, and also reverted DET- or DETD-35-induced reprogramming exosomal protein expression profiles resulting in attenuation of exosomal toxicity against TNBC cell proliferation. In summary, this study shows that a plant-derived sesquiterpene lactone DET and its analog DETD-35 inhibitory TNBC cell activities through oxidative stress-induced cancer cell releasing exosomes in tandem with alteration of exosomal protein composition and functions. The findings of this study suggest that DETD-35 may be suitable for further development into an anti-TNBC drug.
Energy scaling of cold atom-atom-ion three-body recombination
Creators: name: Krükow, Artjom
name: Mohammadi, Amir
name: Härter, Arne
name: Denschlag, Johannes Hecker
name: Pérez-Ríos, Jesús
name: Greene, Chris H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We study three-body recombination of Ba$^+$ + Rb + Rb in the mK regime where a single $^{138}$Ba$^{+}$ ion in a Paul trap is immersed into a cloud of ultracold $^{87}$Rb atoms. We measure the energy dependence of the three-body rate coefficient $k_3$ and compare the results to the theoretical prediction, $k_3 \propto E_{\textrm{col}}^{-3/4}$ where $E_{\textrm{col}}$ is the collision energy. We find agreement if we assume that the non-thermal ion energy distribution is determined by at least two different micro-motion induced energy scales. Furthermore, using classical trajectory calculations we predict how the median binding energy of the formed molecules scales with the collision energy. Our studies give new insights into the kinetics of an ion immersed into an ultracold atom cloud and yield important prospects for atom-ion experiments targeting the s-wave regime.
description: 5 pages, 4 figures
Confinement of superconducting fluctuations due to emergent electronic inhomogeneities
Creators: name: Carbillet, C.
name: Caprara, S.
name: Grilli, M.
name: Brun, C.
name: Cren, T.
name: Debontridder, F.
name: Vignolle, B.
name: Tabis, W.
name: Demaille, D.
name: Largeau, L.
name: Ilin, K.
name: Siegel, M.
name: Roditchev, D.
name: Leridon, B.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: The microscopic nature of an insulating state in the vicinity of a superconducting state, in the presence of disorder, is a hotly debated question. While the simplest scenario proposes that Coulomb interactions destroy the Cooper pairs at the transition, leading to localization of single electrons, an alternate possibility supported by experimental observations suggests that Cooper pairs instead directly localize. The question of the homogeneity, granularity, or possibly glassiness of the material on the verge of this transition is intimately related to this fundamental issue. Here, by combining macroscopic and nano-scale studies of superconducting ultrathin NbN films, we reveal nanoscopic electronic inhomogeneities that emerge when the film thickness is reduced. In addition, while thicker films display a purely two-dimensional behaviour in the superconducting fluctuations, we demonstrate a zero-dimensional regime for the thinner samples precisely on the scale of the inhomogeneities. Such behavior is somehow intermediate between the Fermi and Bose insulator paradigms and calls for further investigation to understand the way Cooper pairs continuously evolve from a bound state of fermionic objects into localized bosonic entities.
description: 29 pages 9 figures
Sonnenfleckenzeichnung Nr. 161.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 09.07.1984, 07:15, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1984

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Sonnenfleckenzeichnung Nr. 80.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 07.04.1984, 08:15, erstellt von Marco Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1984

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Endurance Training Intensity Does Not Mediate Interference to Maximal Lower-Body Strength Gain during Short-Term Concurrent Training
Creators: name: Bishop, David J.
name: Bartlett, Jonathan D.
name: Fyfe, Jackson J.
name: Stepto, Nigel K.
name: Hanson, Erik D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: We determined the effect of concurrent training incorporating either high-intensity interval training (HIT) or moderate-intensity continuous training (MICT) on maximal strength, counter-movement jump (CMJ) performance, and body composition adaptations, compared with single-mode resistance training (RT). Twenty-three recreationally-active males (mean ± SD: age, 29.6 ± 5.5 y; V˙O2peak, 44 ± 11 mL kg−1·min−1) underwent 8 weeks (3 sessions·wk−1) of either: (1) HIT combined with RT (HIT+RT group, n = 8), (2) work-matched MICT combined with RT (MICT+RT group, n = 7), or (3) RT performed alone (RT group, n = 8). Measures of aerobic capacity, maximal (1-RM) strength, CMJ performance and body composition (DXA) were obtained before (PRE), mid-way (MID), and after (POST) training. Maximal (one-repetition maximum [1-RM]) leg press strength was improved from PRE to POST for RT (mean change ± 90% confidence interval; 38.5 ± 8.5%; effect size [ES] ± 90% confidence interval; 1.26 ± 0.24; P < 0.001), HIT+RT (28.7 ± 5.3%; ES, 1.17 ± 0.19; P < 0.001), and MICT+RT (27.5 ± 4.6%, ES, 0.81 ± 0.12; P < 0.001); however, the magnitude of this change was greater for RT vs. both HIT+RT (7.4 ± 8.7%; ES, 0.40 ± 0.40) and MICT+RT (8.2 ± 9.9%; ES, 0.60 ± 0.45). There were no substantial between-group differences in 1-RM bench press strength gain. RT induced greater changes in peak CMJ force vs. HIT+RT (6.8 ± 4.5%; ES, 0.41 ± 0.28) and MICT+RT (9.9 ± 11.2%; ES, 0.54 ± 0.65), and greater improvements in maximal CMJ rate of force development (RFD) vs. HIT+RT (24.1 ± 26.1%; ES, 0.72 ± 0.88). Lower-body lean mass was similarly increased for RT (4.1 ± 2.0%; ES; 0.33 ± 0.16; P = 0.023) and MICT+RT (3.6 ± 2.4%; ES; 0.45 ± 0.30; P = 0.052); however, this change was attenuated for HIT+RT (1.8 ± 1.6%; ES; 0.13 ± 0.12; P = 0.069). We conclude that concurrent training incorporating either HIT or work-matched MICT similarly attenuates improvements in maximal lower-body strength and indices of CMJ performance compared with RT performed alone. This suggests endurance training intensity is not a critical mediator of interference to maximal strength gain during short-term concurrent training.
From the early to the late time universe within $f(T,\mathcal{T})$ gravity
Creators: name: Nassur, S. B.
name: Houndjo, M. J. S.
name: Kpadonou, A. V.
name: Rodrigues, M. E.
name: Tossa, J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this paper we perform the reconstruction scheme of the gravitational action within $f(T,\mathcal{T})$ gravity, where $T$ and $\mathcal{T}$ denote the torsion scalar and the trace of the energy momentum tensor, respectively. We particularly focus our attention on the case where the algebraic function $f(T,\mathcal{T})$ is decomposed as a sum of two functions $f_1(T)$ and $f_2(\mathcal{T})$, i.e, $f(T,\mathcal{T})=f_{1}(T)+f_{2}(\mathcal{T})$. The description is essentially based on the scale factor and then, we consider two interesting and realistic expressions of this parameter and reconstruct the action corresponding to each phase of the universe. Our results show that some $f(T,\mathcal{T})$ models are able to describe the evolution of the universe from the inflation phase to the late time dark energy dominated phase.
description: 23 pages
Sonnenfleckenzeichnung Nr. 36.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 13.02.1984, 08:15, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1984

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Sonnenfleckenzeichnung Nr. 22.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 24.01.1984, 08:45, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1984

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 2.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Gender and the primary health care sytem: Digital tools
Creators: name: Garfinkel, Sydney
name: Ingle, Erin
name: Seth, Aparna
name: Shrestha, Priyanka
name: Patel, Rena
name: Badshah, Akhtar
name: START Center
Publisher: name: Gates Open Research
Year: 2023

description: The Foundation was interested in broadly understanding the application of patient-facing tools that increase digital access for marginalized groups, including girls and women, to primary health care (PHC) in LMICs. This research demonstrates the learning and key results from expanding digital access in LMICs and how to avoid further neglecting marginalized groups. The report uses insights from other sectors who have pioneered approaches to increase digital access to service delivery in their sectors and how we can translate this to the PHC sector. Finally, the report provides key recommendations for how to make digitization more gender equitable in LMICs. Data collection was completed using a literature review and KIIs.
Pre-dive Whole-Body Vibration Better Reduces Decompression-Induced Vascular Gas Emboli than Oxygenation or a Combination of Both
Creators: name: Guerrero, François
name: Theunissen, Sigrid
name: Le Mener, Cedric
name: Lafère, Pierre
name: Balestra, Costantino
name: Papadopoulou, Virginie
name: Germonpré, Peter
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Purpose: Since non-provocative dive profiles are no guarantor of protection against decompression sickness, novel means including pre-dive “preconditioning” interventions, are proposed for its prevention. This study investigated and compared the effect of pre-dive oxygenation, pre-dive whole body vibration or a combination of both on post-dive bubble formation.