cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Safety and short term outcomes of a new truly minimally-invasive mesh-less and dissection-less anchoring system for pelvic organ prolapse apical repair
Creators: name: Weintraub, Adi Y.
name: Ben Zvi, Masha
name: Yohay, David
name: Neymeyer, Joerg
name: Reuven, Yonatan
name: Neuman, Menahem
name: Tsivian, Alex
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Prolapse
subject: Minimally Invasive Surgical Procedures
subject: Pelvic Floor Disorders
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Objective To evaluate the safety and short term outcomes of a new, truly minimally-invasive, mesh-less and dissection-less anchoring system for pelvic floor apical repair. Methods A prospective study was conducted using the NeuGuide™ device system for pelvic floor apical repair. The primary effectiveness outcome was centro-apical pelvic floor prolapse by POP-Q after six months. The primary safety outcome was intra-operative, immediate (first 48 h) post-operative complications and adverse effects after six months. A standardized questionnaire (UDI-6) to assess quality of life at entry and during follow-up visits was used. Patients’ six months-follow-up and evaluation are reported. Results The mean age of the study population (n=10) was 63.8±12.0 years. All patients had a previous prolapse surgery. Five had a previous hysterectomy and two had stress urinary incontinence symptoms. During surgery six patients had a concurrent colporrhaphy. There was no injury to the bladder, rectum, pudendal nerves, or major pelvic vessels and no febrile morbidity was recorded. At six months, no cases of centro-apical recurrence were noted. Patients were satisfied with the procedure and had favorable quality of life scores. Using the UDI-6 questionnaire an improvement, in all domains was seen. Moreover, although the sample size was small, the improvement in urge and overflow incontinence related domains were demonstrated to be statistically significant. Conclusions This new NeuGuide™ device allows rapid and safe introduction of a suspending suture through the sacrospinous ligament and makes sacrospinous ligament fixation easy to perform, while avoiding dissection and mesh complications.
Megestrol acetate improves cardiac function in a model of cancer cachexia- induced cardiomyopathy by autophagic modulation
Creators: name: Musolino, Vincenzo
name: Palus, Sandra
name: Tschirner, Anika
name: Drescher, Cathleen
name: Gliozzi, Micaela
name: Carresi, Cristina
name: Vitale, Cristiana
name: Muscoli, Carolina
name: Doehner, Wolfram
name: Von Haehling, Stephan
name: Anker, Stefan D.
name: Mollace, Vincenzo
name: Springer, Jochen
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Cachexia is a complex metabolic syndrome associated with cancer. One of the features of cachexia is the loss of muscle mass, characterized by an imbalance between protein synthesis and protein degradation. Muscle atrophy is caused by the hyperactivation of some of the main cellular catabolic pathways, including autophagy. Cachexia also affects the cardiac muscle. As a consequence of the atrophy of the heart, cardiac function is impaired and mortality is increased. Anti-cachectic therapy in patients with cancer cachexia is so far limited to nutritional support and anabolic steroids. The use of the appetite stimulant megestrol acetate (MA) has been discussed as a treatment for cachexia. Methods In this study the effects of MA were tested in cachectic tumour-bearing rats (Yoshida AH-130 ascites hepatoma). Rats were treated daily with 100 mg/kg of MA or placebo starting one day after tumour inoculation, and for a period of 16 days. Body weight and body composition were assessed at baseline and at the end of the study. Cardiac function was analysed by echocardiography at baseline and at day 11. Locomotor activity and food intake were assessed before tumour inoculation and at day 11. Autophagic markers were assessed in gastrocnemius muscle and heart by western blot analysis. Results Treatment with 100 mg/kg/day MA significantly attenuated the loss of body weight (−9 ± 12%, P
Rural broadband technologies and the Rural Broadband Initiative in New Zealand
Creators: name: Treloar, Nicola
Publisher: name: Swinburne
Year: 2024

description: The Rural Broadband Initiative (RBI) is a government initiative focused on closing the 'digital divide' between broadband services in urban and rural New Zealand. This NZ $300 million initiative uses a combination of fixed and wireless technologies to expand broadband coverage to 97.8 percent of New Zealand households and enterprises (and 97.7 percent of schools), providing competition at all levels of the network, and across fixed and wireless technologies. The RBI is expected to lift productivity in the rural sector, contributing to the Government's wider strategy to increase New Zealand's global competitiveness.
Les jeunes de la rue : une forme d'intégration sociale.
Creators: name: Paradis, Isabelle.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Sociology, Individual and Family Studies.

description: Notre projet de recherche concerne les jeunes de la rue. Plus précisément, notre projet se veut une étude d'un groupe de jeunes de la rue, garçons et filles, afin de connaïtre leur parcours ou itinéraire de vie. En fait, c'est tolu particulièrement à travers ces itinéraires que nous pourrons essayer de vérifier si ces jeunes s'intègrent au plan social. Ces jeunes ne sont peut-être pas si à l'écart qu'on le pense et qu'on le dit. Le passage à la rue serait peut-être une forme d'intégration sociale. Cet objet de recherche revêt une importance au plan théorique car c'est toute la question de la marginalité qui est touchée. En effet, ce projet de recherche touche la marginalité de front, d'une part, en mettant en évidence la marginalité de certains jeunes, soit les jeunes de la rue et, d'autre part, en abordant la façon dont la société marginalise une certaine catégorie de jeunes en particulier. (Abstract shortened by UMI.)
Motion of the foot inside a hockey skate: As measured from bone, skin, and skate markers.
Creators: name: Al Hadi, Mouafak.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Biology, Anatomy.

description: In filming and digitizing human segmental motion, external markers do not necessarily represent a true picture of the actual bone movement. When surface markers are placed on the skin or skate boot (in ice hockey) they move according to skin or boot movement, which does not exactly match bone movement. This results in a misrepresentation of the joint axes of rotation and a greater margin of error in motion measurement and analysis. This problem occurs for ankle and foot movements as their motion is quantified about the ankle joint complex (talocrural and subtalar joints). Hockey skates are vastly more rigid than regular shoes and their restriction of foot movement is greater. Therefore, shoes and hockey skates cannot be considered identical. The present study aims at exploring differences amongst bone, skin, and skate marker based motions of the foot during skating. (Abstract shortened by UMI.)
Pascal's "Pensees": Fragments of an epistemology?
Creators: name: Moran, Patrick Quinn
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Philosophy.

description: Epistemology plays an important role in Pascal's Pensees , but nowhere in the Pensees will one find an explicit statement of this epistemology. The aim of this dissertation is to bring the epistemology of the Pensees out by considering Pascal's arguments against scepticism on the one hand and dogmatism on the other. The dissertation is thus divided into three chapters. The first chapter concerns Pascal's refutation of scepticism. Briefly, Pascal's rejects scepticism because it is impossible to put the sceptic's policy of universal doubt into practice. The second chapter concerns Pascal's refutation of dogmatism. According to Pascal, dogmatism fails because it is impossible to use reason to prove some certainties, such as first principles in mathematics, or "All men are mortal". In the third chapter we consider Pascal's positive epistemology. The refutation of scepticism shows that knowledge is possible, but the refutation of dogmatism shows that some knowledge is beyond reason. Since a complete epistemology accounts for the knowledge that is beyond reason (which Pascal calls "Knowledge by the heart") as well as the knowledge that is not beyond reason, this final chapter concerns how knowledge beyond reason may be accounted for, according to Pascal. In a word, knowledge by the heart is accounted for by identifying it as self-evidence. (Abstract shortened by UMI.)
The role of internal actors’ interests in UN arms embargo and the US arms sales policies
Creators: name: Nam, Hoshik
Publisher: name: University of Iowa
Year: 2025
Subjects: public abstract

description: This dissertation seeks to understand why only some countries with human rights violations become the targets of military sanctions and arms trade restrictions. I suggest that the underlying political interests of actors within the UN Security Council and US Congress affect the UN targeted sanctions on arms transfers and congressional oversight efforts on arms exports respectively. First, I find that the alliance relationships between the permanent members of the UNSC and potential target countries have deterring effects on the impositions of UN arms embargoes. Regarding US arms exports, I find that congressional committees with jurisdiction over arms exports are more likely to propose joint resolutions to block arms sales plans when the recipient countries are non-democratic regimes with higher humanitarian violations. Lastly, by examining individual roll call votes of arms sales plans, I find that ideology and partisanship significantly influence the voting behavior of individual members in relation to financial contributions from defense contractors. My dissertation emphasizes the importance of both international (such as alliance) and domestic (such as partisanship and lobbying) interests by highlighting their influences over policy decisions of the UNSC and US Congress regarding their restriction efforts on arms transfers.
A study of the behaviour of viscoelastic fluids in constant pressure filtration.
Creators: name: Slegr, Helen Tania.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Engineering, Chemical.

description: A filtration theory for constant pressure filtration in viscoelastic media is presented. The theory is based on the linearized capillary hybrid model for flow in a porous medium. The main filtration equation is quite similar to that for non-Newtonian filtration except for the parameter $v\sb{me}$ representing a sum of two terms: one term characterizing the viscous (Newtonian) nature of the flow, and the second term portraying the elastic contribution to the flow. Constant pressure filtration experiments are performed using slurries of calcium carbonate in aqueous solutions of high molecular weight polyacrylamide (viscoelastic slurries) and slurries of calcium carbonate and water (Newtonian slurries). Three pressure drops are employed: 345 kPa, 517 kPa, and 689 kPa. The filtration theory provides a means to compile the experimental data, wherein filter cake and filter medium resistances are computed and compared. It is found that the filter cake resistances of the viscoelastic filtrations were considerably lower than those of the Newtonian filtrations. Furthermore, the filter medium resistances of the viscoelastic filtrations were, in general, higher than those of the Newtonian filtrations.
Evaluation of the goodness-of-fit index Mord in polytomous DCMs with hierarchical attribute structures
Creators: name: Yuan, Haimiao
Publisher: name: University of Iowa
Year: 2022
Subjects: Diagnostic classification model
Goodness of fit
Hierarchical
Polytomous
public abstract

description: The application of diagnostic classification models (DCMs) in the field of educational measurement is getting more attention in recent years. To make a valid inference from the model, it is important to ensure that the model fits the data. The purpose of the present study was to investigate the performance of the limited information goodness-of-fit statistic Mord in the polytomous response DCMs with the presence of hierarchical attribute structures. The first simulation study investigated the empirical Type I error rates of the Mord statistic under the null hypothesis when the model and data were perfectly fitted. The second simulation study explored the empirical rejection rate of Mord under different types of misspecifications: model misspecification, attribute hierarchy misspecification, and Q-matrix misspecification. The impact of test length, item quality, attribute structure, marginal/conditional probability of the mastery of attributes, and the number of response categories were investigated.
description: The results indicated that the Mord statistic demonstrated well-calibrated Type I error rates under the null conditions with different types of hierarchical attribute structures. When there were model-data misfits, the Mord statistic showed high empirical rejection rates in detecting the misspecified sDINA and sDINO but didn’t show enough power to detect the sC-RUM. The Mord also exhibited high empirical rejection rates when the generating attribute structure was non-strict hierarchical, but the fitted structure was strict hierarchical. Besides, it was sensitive when the sequence of parent and child attributes was reversed. However, the Mord statistic couldn’t detect the omission of hierarchical attribute connections. When there were Q-matrix misspecifications, the Mord statistic showed extremely high empirical rejection rates in the condition of Q-matrix under-specification but was not sensitive to the Q-matrix over-specification. The higher proportion of Q-matrix misspecification led to higher Mord rejection rates. The item quality exhibited a huge influence on the performance of the Mord statistic. The Mord statistic demonstrated higher empirical rejection rates with higher item quality, longer test length, fewer item response categories, and lower marginal/conditional probability of the mastery of attributes. The types of attribute structure also demonstrated slight influences on the rejection rates of the Mord statistics under some circumstances. The performance of the RMSEAord and SRMSR were explored in the present study to assess the degree of misfit and absolute model fit. The results indicated that the frequently used cut-off value of 0.05 was not appropriate in the framework of polytomous response DCMs. The magnitude of RMSEAord and SRMSR values varied in different situations.
The More I Know, The Less I Understand
Creators: name: Dawson, Maria
name: Liu, Joe
name: Denault, John
name: Cheung, Melody
name: Brewster, Sara
name: Hass, Riley
name: Tsang, Vivian
name: Ng, Joanne
name: Ferguson, Megan
name: Halaburda, Carlos Gustavo
name: Franzen, Carolina
name: Wachtel, Amir
name: Passey, Jessica
name: Shaw, Meredith
name: Winckler, Emily
name: Hill, Ellyn
name: Galpin, Mikiko
name: Tong, Audrey
name: Kim, Jae Hyun
name: Bryn-Mcleod, Helena
Publisher: name: Auschwitz-Birkenau State Museum
Year: 2022

description: The essays that you will find in this book are the result of a long journey. They have been written by undergraduate students who came to Poland from the University of British Columbia (Vancouver, Canada), as a part of the intensive research seminar Witnessing Auschwitz. Coming from various backgrounds, personal as well as academic, students invested an incredible amount of time and dedication into learning about the camp and the crimes committed there. Each study in this volume is based on the unique interests of these young researchers and will highlight a particular aspect of history related to Auschwitz. The texts come with invaluable footnotes by experts in the field who accompanied our students with advice and support throughout their research. With The More I Know, The Less I Understand, UBC students share with you their insights on the topics where they have focused their dedication and their intellect. “Witnessing Auschwitz – Conflicting Stories and Memories” is an intensive research seminar developed by scholars from the University of British Columbia (UBC), the Auschwitz-Birkenau State Museum, and the Emanuel Ringelblum Jewish Historical Institute. Each spring since 2014, a new group of students from UBC has travelled to Poland for a month of lectures and study tours on subjects pertaining to pre-war Jewish life and the Holocaust in Poland. Students spend two weeks at the Auschwitz-Birkenau State Museum where they work and study with the Museum’s historians, collections specialists, and members of its publishing house and education centre. They spend another two weeks studying in Warsaw, Kraków, and Białystok. By the end of the program, students have developed research topics deeply rooted in the scholarship to which they have been exposed while in Poland. The essays in this volume are the result of this inspiring and important international, scholarly, and educational collaboration.
title: Anti-Hero
title: revenge of the Sw*fties, a play
titleType: Subtitle
Creators: name: Edgren Otero, Derick
Publisher: name: University of Iowa
Year: 2024
Subjects: New Play Development
Playwriting
Theatre
Play

description: Anti-Hero: Revenge of the Swifties is a new full-length play in which fourteen-year-old Cora harasses a prominent music critic and his family into changing his scathing review of a country-turned-pop star’s most divisive record. When he ignores her demands, a fandom rises up to save their queen’s reputation. This play is about going to Target. It’s about being on your phone. It’s about looking camp right in the eye. It’s about turning our habits of consumption into ones of creation.
title: Professional Use of Social Media by Pharmacists
title: A Qualitative Study
titleType: Subtitle
Creators: name: Benetoli, Arcelio
name: Chen, Timothy Frank
name: Schaefer, Marion
name: Chaar, Betty B.
name: Aslani, Parisa
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: social media
subject: social networks
subject: social networking sites
subject: YouTube
subject: Wikipedia
subject: Facebook
subject: pharmacists
subject: pharmacy
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik

description: Background: Social media is frequently used by consumers and health care professionals; however, our knowledge about its use in a professional capacity by pharmacists is limited. Objective: Our aim was to investigate the professional use of social media by pharmacists. Methods: In-depth semistructured interviews were conducted with practicing pharmacists (N=31) from nine countries. Interviews were recorded, transcribed verbatim, and thematically analyzed. Results: Wikipedia, YouTube, and Facebook were the main social media platforms used. Professional use of social media included networking with peers, discussion of health and professional topics, accessing and sharing health and professional information, job searching, and professional promotion. Wikipedia was the participants’ first choice when seeking information about unfamiliar topics, or topics that were difficult to search for. Very few pharmacy-related contributions to Wikipedia were reported. YouTube, a video-sharing platform, was used for self-education. University lectures, “how-to” footage, and professionally made videos were commonly watched. No professional contribution was made to YouTube. Facebook, a general social networking site, was used for professional networking, promotion of achievements, and job advertisements. It also afforded engagement in professional discussions and information sharing among peers. Conclusions: Participants used social media in a professional capacity, specifically for accessing and sharing health and professional information among peers. Pharmacists, as medicines experts, should take a leading role in contributing to health information dissemination in these user-friendly virtual environments, to reach not only other health care professionals but also health consumers. J Med Internet Res 2016;18(9):e258 doi:10.2196/jmir.5702
Cell cycle dependency of cisplatin cytotoxicity on ovarian cancer cells.
Creators: name: Hosseini Shirazi, Seyed Farshad.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Biology, Molecular.

description: The cytotoxicity of Cisplatin (CDDP) is traditionally believed to be cell cycle independent. This general belief is not in agreement with CDDP-induced apoptosis. Therefore, cell cycle dependency of cisplatin was investigated using human ovarian carcinoma OV 2008 cell line synchronized at the different phases of the cell cycle (i.e. subpopulations). Clonogenic assay, flow cytometry, fluorescence microscopy, electron microscopy (EM), atomic absorption spectroscopy (AA), and various biochemical techniques were used in this project. OV 2008 cell subpopulations at the different phases of G1, G1/S, S and G2/M were exposed to 1 m g/ml of CDDP for one hour (n = 3). CDDP resulted in 66 +/- 6(SE)%, 50 +/- 6%, 42 +/- 5%, and 41 +/- 5% survival for cells in G2/M, S, G1/S boundary and G1 of the cell cycle, respectively. Flow cytometry confirmed a general pattern of arrest in S and G2/M for all subpopulations, in spite of the different percentages of death. A cell cycle delay in arrest was noted when cells were exposed to CDDP in late S or G2/M, but not for the other two phases. EM revealed both apoptotic and necrotic cell death. For all subpopulations, the appearance of apoptotic and necrotic cells were 70% and 30% in about 12 hours, with 25% and 75% in 30 hours, respectively. All subpopulations of cells had accumulated the same amount of intracellular elemental platinum after exposure to CDDP. However, different amounts of DNA adducts were formed for cells in each subpopulation. In general, the rank order of CDDP cytotoxicity on the different phases of OV 2008 cell cycle is as follows; G1>G1/S>S>G2/M. This rank order is found in good agreement with the rank order of CDDP-DNA binding, as well as intracellular acidity (pHi) of OV 2008 cells; being at the lowest pH in G1 and highest in G2/M. Control experiments have shown the conversion of CDDP to its active metabolite of aquated CDDP (AP) in acidic media. pH dependent metabolism of CDDP to AP, which will then bind to DNA was confirmed. We have concluded that OV 2008 cells have different sensitivity to CDDP at the different phases of the cell cycle, which is related to the variations in pHi, and consequently the intracellular metabolism of CDDP to AP.
Développement d'une méthodologie permettant l'insertion d'un méthyle en C8 d'une trans-décaline ainsi que son application à la synthèse du (+-)-desdimethylambliol B et de la (+-)-desdimethylagelasimine A
Creators: name: Goulet, Nathalie Marie-Lyne
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Chemistry, General.

description: Le développement d'une stratégie qui permet d'installer un groupement méthyle sélectivement en position C8 d'une trans décaline est décrit. La réaction en tandem oxy-Cope/ene/Claisen avec un groupement directeur dans le précurseur, tel un sulfure d'éthyle, permet de n'obtenir qu'un seul diastéréoisomère (Schéma i).* Cette méthodologie a permis de synthétiser l'analogue sans le gem-diméthyle en C4 du produit naturel ambliol B (Schema u).* Cette méthodologie a aussi permis le deéeloppement de la synthèse d'un analogue d'agelasimine A, soit (+/-)-desdimethylagelasimine A. Cette étude s'est terminée à quelques étapes de la fin. Les défis majeurs de cette synthèse étant résolus, l'accomplissement de cette dernière constitue une formalité (Schéma iii).* *Please refer to dissertation for diagrams.
title: A validated LC-MS/MS method for cellular thyroid hormone metabolism
title: Uptake and turnover of mono-iodinated thyroid hormone metabolites by PCCL3 thyrocytes
titleType: Subtitle
Creators: name: Richards, Keith H.
name: Schanze, Nancy
name: Monk, Ray
name: Rijntjes, Eddy
name: Rathmann, Daniel
name: Köhrle, Josef
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Tyrosine and phenolic ring de-iodination of thyroid hormones (TH) is crucial for regulating their physiological activity. Furthermore, reactions such as de-carboxylation to thyronamines (TAM) and de-amination to thyroacetic acids (TAc) produce TH metabolites (THM) with distinct biological properties. This needs to be considered when studying effects of TH and THM. The accurate and precise quantitative analysis of TH and THM in cell culture supernatants and cell lysates are key procedures required for studying the in vitro metabolism of TH. We report here the development of a liquid-liquid extraction/isotope dilution-liquid chromatography-electrospray tandem mass spectrometry (LC- MS/MS) method for the quantification of 9 thyronines (TN) and 6 TAM in human hepatocellular carcinoma Hep G2 cell lysate extracts. In addition, we adapted the method to quantify TH, TAM and TAc, in cell lysates of FBS-depleted rat thyroid epithelium PCCL3 cells. The methods for both cell lines were validated by rigorous assessment of linearity, limits of quantification and detection (LLOQ and LLOD respectively), intra- and inter-day accuracy, precision, process efficiency (PE), matrix effect (ME) and relative recovery (RE). Calibration curves covering 11 concentrations (based on 400 μl of lysate) were linear in the range 0.016–50 nM and 0.010–50 nM for Hep G2 and PCCL3 cells respectively. The lower limits of quantification were in the range 0.031 to 1 nM. We applied the PCCL3 version of the LC-MS/MS method to the analysis of lysed cell extracts from PCCL3 cells that had been incubated with 3-iodo-L-thyronine (T1), 3-iodothyronamine (3-T1AM) and 3-iodothyroacetic acid (3-T1Ac). Over the course of 30 minutes incubation 3-T1AM was de-iodinated to 4-[4-(2-aminoethylphenoxy)]phenol (thyronamine, T0AM) and de-aminated to 3-T1Ac respectively, whilst T1 underwent de-iodination to T0. This data indicates avid metabolism of these mono-iodinated compounds and the utility of LC-MS/MS to quantify such cellular metabolism.
Vascular progenitor cell and extracellular matrix protein interactions in cancer
Creators: name: Labonte, Laura E
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Biology, Molecular.

description: Vascular progenitor cells (VPCs) facilitate angiogenesis and vascular repair in damaged tissues where inflammatory cytokines coordinate healing through VPC mobilization. VPCs also facilitate tumor angiogenesis and induce angiogenic switching in metastatic sites. VPC binding to extracellular matrix proteins enriched in injured healing tissues and metastatic sites and the participation of integrins in this binding was investigated. VPC binding profiles on fibronectin and laminin of "healthy" controls was different from those of "cancer" patients and patients with acute tissue damage. Specific integrin-mediated binding of cells in VPC clusters were matrix protein-dependent. Patients with oral cancer and lymphoma had elevated plasma vascular endothelial growth factor (VEGF) levels compared to healthy controls. VEGF facilitated VPC clustering on fibronectin and incubating cells from healthy controls with VEGF switched binding profiles from "healthy" to "cancer". This study provided new insights regarding VPC-matrix interactions that help distinguish VPC involvement in vascular repair from vascular-mediated metastasis.
Somatostatin receptor PET/CT in restaging of typical and atypical lung carcinoids
Creators: name: Prasad, Vikas
name: Steffen, Ingo G.
name: Pavel, Marianne
name: Denecke, Timm
name: Tischer, Elisabeth
name: Apostolopoulou, Konstantina
name: Pascher, Andreas
name: Arsenic, Ruza
name: Brenner, Winfried
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: Lung carcinoids
subject: Atypical carcinoid
subject: Typical carcinoid
subject: Somatostatin receptor
subject: PET/CT
subject: Management
subject: Restaging
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background To assess the role of somatostatin receptor (SR) PET/CT using Ga-68 DOTATOC or DOTATATE in staging and restaging of typical (TC) and atypical (AC) lung carcinoids. Methods Clinical and PET/CT data were retrospectively analyzed in 27 patients referred for staging (N = 5; TC, N = 4; AC, N = 1) or restaging (N = 22; TC, N = 8; AC, N = 14). Maximum standardized uptake value (SUVmax) of SR-positive lesions was normalized to the SUVmax of the liver to generate SUVratio; SR PET was compared to contrast-enhanced (ce) CT. The classification system proposed by Rindi et al. (Endocr Relat Cancer. 2014;21(1):1-16, 2014) was used for classification of patients in TC and AC groups. Results Only 18/27 patients were found to have metastases on PET/CT. Of the 186 lesions, 101 (54.3 %) were depicted on both PET and CT, 53 (28.5 %) lesions only on CT, and 32 (17.2 %) only on PET. SUVratio of lesions was significantly higher in AC as compared to TC (p
Use of dynamic programming and particle swarm optimization techniques for solving security and unit commitment problems
Creators: name: Borra, Venkata Silpa
Publisher: name: Charles Darwin University
Year: 2019

description: Power system security and Unit Commitment are two important tasks in power system operation. Power system security is the ability of the system to continue supplying power to consumers in spite of faults and occasional breakdown of some equipment. Power systems are designed with generation capacities larger than peak demands so that the total demand at any time can be met even in the event of failure of one or two largest generating units. The generating units have to run continuously to meet the load demand. Unit Commitment is the task of selecting the best generating unit(s) to be committed. The committed units must satisfy the fuel cost and CO2 emissions constraints. In this thesis, we considered a small power system (microgrid) consisting of ten subsystems. Although, each subsystem contains Photovoltaic, battery and Micro Gas Turbines, their capacities are not identical. A Microgrid Central Energy Management System is utilised for solving the security and Unit Commitment problems. This energy management system is a MATLAB program written for the purpose of solving the above two problems. In the simulation, we first used Dynamic Programming for solving security and Unit Commitment problems. A fault was applied to one of the subsystems causing a loss of some generation. Dynamic Programming has been able to correctly identify the fault and allocate the necessary amount of generation from another subsystem to compensate for the lost power. Being cheap and environmentally friendly, Photovoltaic should be the primary generation allocated even if they belong to a different subsystem. Unfortunately, the Dynamic Programming allocated Micro Gas Turbines in some cases even though sufficient Photovoltaic generation was available. This is due to the fact that the Dynamic Programming provides only a local solution instead of a global solution. Dynamic Programming is not, therefore, totally acceptable for solving the security and Unit Commitment problems. Next, we resorted to a second technique i.e., Particle Swarm Optimization. We applied a fault to a subsystem just as we did in the concept of Dynamic Programming. This technique also correctly identified the fault and allocated the available Photovoltaic generation from another subsystem to compensate for the lost generation. Particle Swarm Optimization used Micro Gas Turbines only when all Photovoltaic generation from all the subsystems has been used. This technique has satisfied both the security as well as Unit Commitment problems in an acceptable manner. The Particle Swarm Optimization has also been able to correctly identify the faults. When, we applied two random faults in the same or different subsystems. This technique has also recommended necessary Photovoltaic generation from another subsystem. It is obvious that the Particle Swarm Optimization was accurate and more acceptable than the Dynamic Programming for solving security and Unit Commitment problems.
Mental training sessions between an eminent consultant and elite level athletes: A case study.
Creators: name: Lloyd, Rebecca Jane.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Education, Physical.

description: A case study design was used to describe (a) an eminent mental training consultant's published approach to consulting, (b) the content and the process of the verbal interactions between an eminent mental training consultant and four elite level athletes during ten authentic mental training sessions, and (c) the congruencies between the consultant's published approach and the content and process of the mental training sessions. The sources of information were literature published by the consultant, audio recordings of the mental training sessions, interview with the consultant and interviews with the athletes. An inductive analysis was used with each source of information and an adapted version of the Flanders' (1965) Interaction Analysis in the Classroom was used to systematically code the process. The seven elements of excellence from Orlick's Wheel (1995) were apparent in the content of the sessions. Other categories that emerged were physical elements, injury, emotion, relations with others, transition, balance, competition, outcome, intensity, artistic presentation, money and audio/visual materials. During the sessions, the consultant's verbal behaviours accounted for 39% of the total coded behaviours were 21% were classified as indirect and 18% as direct. Sixty percent of the total coded behaviours wre the athletes responding, initiating or asking questions. One percent of the time was spent in silence. Both the analysis of the content and the process confirmed the consultant's athlete-centered approach to consulting. The comparison of the consultant's published approach with the analysis of the content and the analysis or the process of the mental training sessions indicated that the consultant actually did what he reported to do, i.e., follows an athlete-centered approach.
An exploration of newlyweds’ experiences in the transition into marriage using relational uncertainty and uncertainty management theory
Creators: name: Reed, Jaclyn Marie
Publisher: name: University of Iowa
Year: 2023
Subjects: newlywed
parental divorce
relational uncertainty
uncertainty
uncertainty management
public abstract
Marriage

description: The aim of this dissertation study is to examine newly married individuals’ experiences with uncertainty and uncertainty management through a relational uncertainty and uncertainty management theoretical framework. I conducted 50 semi-structured interviews over zoom.com using the audio-only function. I purposefully sampled newlyweds who experienced parental divorce (N= 23) and those who did not (N= 27). I took a two-step approach to examining these interviews. First, I conducted a content analysis to reveal newlyweds’ uncertainties and how they communicatively managed their uncertainty. Then, I used the themes to generate codebooks and conducted a content analysis to determine if there were any significant differences between newlyweds based on their parents’ marital status.
description: Findings suggest that newlyweds experience five themes of uncertainties: happiness and stability in marriage, uncertainty about the transition into marriage, uncertainty about life course decisions, uncertainty about day-to-day spousal dynamics, and family system uncertainty. Between newlyweds with divorced and nondivorced families, newlyweds with divorced families were more likely to experience uncertainty about happiness and stability in marriage overall, to be uncertain about how to have a happy marriage, and to doubt their own ability to be a good spouse. Newlyweds chose to manage their uncertainty through a myriad of ways including strategic information avoidance, strategic information seeking through collaboration, and conversationally managing uncertainty with spouse. Newlyweds did not significantly differ in their uncertainty management strategies, but it is interesting to note that all fifty participants spoke to their spouse about at least one uncertainty, highlighting the important role of spouses in uncertainty management in the transition into marriage.
description: Findings suggest that newlyweds who experienced parental divorce more frequently report uncertainties relating to the happiness and stability of marriage compared to newlyweds from non-divorced families. I discuss the implications of my findings on the literature, address this study’s limitations and propose future directions for newlywed research.
The life and times of germanium and tin complexes ligated by amidinates and guanidinates and exploratory studies in the use of these ligands in the formation of iron complexes.
Creators: name: Foley, Stephen R.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Chemistry, Inorganic.

description: The overall objectives in the creation of this work were to investigate the structure and reactivity of the group 14 elements germanium and tin supported by amidinates and guanidinates. Chapter One outlines features of the supporting ligation used throughout the thesis. Chapter Two describes the first characterized amidinate complexes of Ge using alkylamidinates as ancillary ligands. Chapter Three represents the first comprehensive study of a heteronuclear intermetal two-electron sulfur atom transfer between Sn and Ge. Complete sulfur atom exchange between amidinate complexes of tin and germanium was achieved through the reaction of (CyNC(tBu)NCy) 2Sn=S with (CyNC(tBu)NCy)2Ge to form the corresponding germanium sulfide (Ge=S) and stannylene. Chapter Four is concerned with the cleavage of chalcogen-chalcogen bonds as routes to the formation of rare chalcogenolates of tin and germanium. Unusual cyclic tin tetrasulfido complexes {(CyNC(R)NCy)[N(SiMe3 )2]}MS4 (M = Sn, R = Me, tBu; M = Ge, R = Me) were prepared by the reaction of elemental sulfur with the divalent group 14 starting materials [CyNC(R)NCy]M[N(SiMe3)2] (M = Sn, R = Me, tBu; M = Ge, R = Me). In Chapter Five mixed amidinato amido complexes [Me 3SiNC(tBu)NSiMe3]M[N(SiMe 3)2] (M = Sn, Ge) were prepared by the reaction of [Me 3SiNC(tBu)NSiMe3]Li with SnCl2 and GeCl2(dioxane) in ether. The N(SiMe3)2 ligand in these compounds is derived from the rearrangement of the [Me 3SiNC(tBu)NSiMe3]- anion with extrusion of tBuCN. The focus of Chapter Six is on the catalytic cyclotrimerization of isocyanates to perhydro-1,3,5-triazine-2,4,6-triones (isocyanurates) at room temperature. In Chapter Seven, we investigate the use of monoanionic N,N',N″-trisubstituted guanidinates as well as the anion of 1,3,4,6,7,8-hexahydro-2H-pyramido[1,2-a]pyramidine (Hhpp) in the formation of both Sn(II) and Sn(IV) complexes. Chapter Eight deals with investigations into the formation of amidinate and guanidinate complexes of both Fe(II) and Fe(III). Presented in this Chapter are results regarding the use of N, N'-dicyclohexylformamidinate as a ligand with Fe(II) to yield Fe4(mu4-O)(mu-Br) 2(mu-CyNCHNCy)4. (Abstract shortened by UMI.)
The coordinate algebra of extended affine Lie algebras of type A(1).
Creators: name: Yoshii, Yoji.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Mathematics.

description: In this thesis we classify the coordinate algebra of extended affine Lie algebras, EALA's for short, of type A1. The coordinate algebras of EALA's of the other reduced types were already described in [6], [7] and [2]. In Chapter 1 we show that the coordinate algebra of EALA's of type A1 is a certain Z n-graded Jordan algebra called a Jordan torus. The main result in this thesis is the classification of Jordan tori. For this purpose we study more general objects, division graded alternative or Jordan algebras in Chapter 2. In Chapter 3 we classify Jordan tori. They fall into five classes namely three types of Hermitian tori, Clifford tori and the Albert torus . Our second goal is the classification of division Z n-graded alternative algebras in Chapter 4, which generalizes the classification of alternative tori in [7]. In the associative case, we get a generalization of quantum tori, and in the nonassociative case, we obtain the Cayley torus or 3 closely related octonion rings . In the final chapter we classify graded forms and derivations of Jordan tori. These results serve as a preparation of classifying tame EALA's of type A 1.
Privacy-preserving collaborative data mining
Creators: name: Zhan, Zhijun Justin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Computer Science.

description: Data mining is a process to extract useful knowledge from large amounts of data. To conduct data mining, we often need to collect data. However, sometimes the data are distributed among various parties. Privacy concerns may prevent the parties from directly sharing the data and some types of information about the data. How multiple parties collaboratively conduct data mining without breaching data privacy presents a grand challenge. Theoretical results from the area of secure multi-party computation show that one may provide secure protocols for any multi-party computation with honest majority. However, the general methods are far from efficient and practical for computing complex functions on inputs consisting of large sets of data. Therefore, to efficiently tackle the problem that is formulated as Privacy-Preserving Collaborative Data Mining, we need to develop privacy-preserving solutions with adequate efficiency. The goal of this dissertation is to provide efficient solutions to the problem of knowledge extraction among multiple parties involved in a data mining task, without disclosing the data between the parties. The distributed data models considered are the vertical collaboration where diverse features of the same set of data are collected by different parties, and the horizontal collaboration where diverse sets of data, all sharing the same features, are gathered by different parties. We develop privacy-preserving protocols for multiple parties to conduct the desired computations. Specifically, we provide solutions for some common data mining algorithms including privacy-preserving association rule mining, privacy-preserving sequential pattern mining, privacy-preserving naive Bayesian classification, privacy-preserving decision tree classification, privacy-preserving k-nearest neighbor classification, privacy-preserving support vector machine classification, and privacy-preserving k-medoids clustering. Our goal is to provide efficient solutions to obtain accurate data mining results and minimize private data disclosure. The solutions are distributed, i.e., there is no central, trusted party having access to all the data. Instead, we define protocols using homomorphic encryption and digital envelope techniques to exchange the data while keeping it private.
Afghan women, media and democracy: Emerging democracy in post-Taliban Afghanistan
Creators: name: Samad, Khorshied
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Women's Studies.
subject: Sociology, Social Structure and Development.
subject: Mass Communications.

description: The current transformation of post-conflict Afghanistan from a war-torn nation to an emerging democracy, and the evolving role of Afghan women in media, politics, and society in post-Taliban Afghanistan are the backdrop against which the theoretical framework of this thesis are tested. Theories of deliberative democracy are investigated, exploring the synergistic intricacies between media and democracy, assessing the extent to which they influence one another. The central research question guiding this study is what role media play in the midst of or in relation to social change. Through historical data, literary sources and interviews, the thesis demonstrates that post-conflict conditions either facilitate or hinder the development of media and the emergence of democracy. It will be argued that without the equal participation of men and women in society, Afghanistan's emerging democracy will remain weak and vulnerable to both internal and external forces of destruction, blocking the country's path to progress.
Lesefreundliche Dokumente in Umweltprüfungen
Creators: name: Grimm, Marie
name: Koller, Maria
name: Köppel, Johann
Publisher: name: My University
Year: 2018
Subjects: subject: Strategische Umweltprüfung
subject: Standardmethode
subject: Bundesbehörde
subject: Rechtsgrundlage
subject: Verfahrensoptimierung
subject: Leitfaden
subject: Planungsverfahren
subject: Bundesrecht
subject: Umweltverträglichkeitsprüfung
subject: UVP-Bericht
subject: Umweltbericht
subject: bürgernahe Sprache
subject: Lesefreundlichkeit
subject: Nachhaltigkeit | Strategien | Internationales

description: Menschen, die im Einwirkungsbereich von Plänen und Projekten leben, sollen anhand der Umweltberichte und ⁠UVP⁠-Berichte erkennen können, ob sie und die Umwelt in der sie leben von Vorhaben oder Planungen betroffen sind. Werden diese Dokumente allerdings nur von Fachleuten verstanden, können sie ihren Zweck nicht erfüllen. Eine bessere Verständlichkeit der Dokumente in Umweltprüfungen kann durch die Beachtung von Schlüsselkonzepten erreicht werden, die im vorliegenden Leitfaden anhand von praxisnahen Beispielen erläutert werden. Der Leitfaden kann daneben auch Anregungen für andere in deutscher Sprache verfasste Umweltdokumente geben.
The identity of cysteine proteinases and their distribution within several major coleopteran families.
Creators: name: Thie, Norman Michael Reinhold.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1991
Subjects: subject: Biology, Entomology.

description: Based on the hydrolysis of synthetic substrates, pH optima for substrate hydrolysis and effects of potential activators and inhibitors, the identity and occurrence of cysteine proteinases in several major coleopteran families were investigated. The larval midgut of the Colorado potato beetle, Leptinotarsa decemlineata contains the cysteine proteinase cathepsin B and H, the aspartate proteinase cathepsin D and leucyl aminopeptidase. Cathepsin B and the serine proteinase trypsin were identified in the larval midgut of the yellow mealworm, Tenebrio molitor. Cathepsin B and the serine proteinase chymotrypsin were identified in the maize weevil, Sitophilus zeamais. The larger grain borer, Prostephanus truncatus, feeds on the same food source as S. zeamais but uses trypsin, chymotrypsin and leucyl and arginyl aminopeptidase and not cysteine proteinases for digestion. Trypsin, leucyl aminopeptidase and arginyl aminopeptidase and not cysteine proteinases were identified in a predacious carabid beetle, Pterostichus corvinus, a predacious tiger beetle, Cicindela sp. and a saprophagous hide beetle, Dermestes maculatus. (Abstract shortened by UMI.)