cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Characterization of the abiotic and biotic drivers of population genomic variation to study the evolutionary consequences of global change
Creators: name: Beer, Marc Andreas
Publisher: name: Washington State University
Year: 2024
Subjects: adaptation
gene flow
landscape genetics
natural selection
population genetics
Evolution

description: The rapid advancement of both theory and technology in the field of population genomics has permitted the evolutionary study of numerous species and thereby enabled the application of novel data and techniques to understanding the ongoing biodiversity crisis. In this dissertation, I analyze population genomic data from three species representing different facets of the biodiversity crisis. Specifically, I study 1) the capacity of an imperiled endemic species to respond evolutionarily to threats posed by global climate change; 2) the evolutionary impacts of shifting ecological interactions between species; and 3) adaptive evolution of an invasive species across its introduced range. The interplay of evolutionary forces, including natural selection, gene flow, and genetic drift, determines the extent to which species evolve population structure and local adaptation. These forces are frequently influenced by environmental conditions. Accordingly, understanding the contemporary relationships between environmental conditions, population structure, and local adaptation may provide critical insights into how species may respond as the environment changes in the future. Herein, I identify genomic signatures of local adaptation to current environmental conditions among populations of the imperiled streamside salamander (Ambystoma barbouri); I couple this knowledge with assessments of genetic diversity and connectivity to better understand the capacity of this species to respond to environmental change. Next, I extend the typical conception of the environment to include interspecific interactions by studying the evolutionary consequences of the competitive interaction between the spotted-tailed quoll (Dasyurus maculatus), a mesopredator, and the Tasmanian devil (Sarcophilus harrisii), a declining top predator. I show that spatiotemporal variation in devil population density, as well as time since the arrival of the devil’s lethal disease, impact genetic connectivity and impose divergent selection among quoll populations. Finally, I use novel methodology to demonstrate geographic variation in genomic signatures of local adaptation among invasive Australian populations of the cane toad (Rhinella marina), thus providing a rare example of how heterogeneous invasion dynamics may impact adaptive evolution of an invasive species post-introduction.
A high affinity RIM-binding protein/Aplip1 interaction prevents the formation of ectopic axonal active zones
Creators: name: Siebert, Matthias
name: Böhme, Mathias A.
name: Driller, Jan H.
name: Babikir, Husam
name: Mampell, Malou M.
name: Rey, Ulises
name: Ramesh, Niraja
name: Matkovic, Tanja
name: Holton, Nicole
name: Reddy-Alla, Suneel
name: Göttfert, Fabian
name: Kamin, Dirk
name: Quentin, Christine
name: Klinedinst, Susan
name: Andlauer, Till F. M.
name: Hell, Stefan W.
name: Collins, Catherine A.
name: Wahl, Markus C.
name: Loll, Bernhard
name: Sigrist, Stephan J.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Synaptic vesicles (SVs) fuse at active zones (AZs) covered by a protein scaffold, at Drosophila synapses comprised of ELKS family member Bruchpilot (BRP) and RIM-binding protein (RBP). We here demonstrate axonal co-transport of BRP and RBP using intravital live imaging, with both proteins co- accumulating in axonal aggregates of several transport mutants. RBP, via its C-terminal Src-homology 3 (SH3) domains, binds Aplip1/JIP1, a transport adaptor involved in kinesin-dependent SV transport. We show in atomic detail that RBP C-terminal SH3 domains bind a proline-rich (PxxP) motif of Aplip1/JIP1 with submicromolar affinity. Pointmutating this PxxP motif provoked formation of ectopic AZ-like structures at axonal membranes. Direct interactions between AZ proteins and transport adaptors seem to provide complex avidity and shield synaptic interaction surfaces of pre-assembled scaffold protein transport complexes, thus, favouring physiological synaptic AZ assembly over premature assembly at axonal membranes. - See more at: http://elifesciences.org/content/4/e06935#sthash.oVGZ8cdi.dpuf
Effect of doping concentration on conversion efficiency of silicon based nano-gap near-field thermophotovoltaic cells
Creators: name: Lau, Japheth Z. J.
name: Wong, Basil T.
Publisher: name: Swinburne
Year: 2024

description: We studied the doping dependence of a nano-gap thermophotovoltaic device that utilises a p-on-n Si photovoltaic cell. The concentration of acceptor dopants, Na in the emitter region was varied from 1023 m-3 to 1025 m-3 while the donor concentration, Nd in the absorber region was varied from 1021 m-3 to 1024 m-3. The combination of Na and Nd that produces the highest conversion efficiency is Na = 1023 m-3 and Nd = 1022 m-3. However, the absorber doping concentration that produces the greatest output power is around 1023 m-3 at all Na values. It is discovered that at higher Na values, the optical response of the device is less sensitive to Nd. It is shown that a decreasing diffusion length does not necessarily jeopardise performance especially when it already exceeds the absorber region thickness. This is due to the positive effects of a decreasing diffusion coefficient.
Effects of name mispronunciation on students’ relationship to education
Creators: name: Widman, Laura
Publisher: name: University of Iowa
Year: 2022
Subjects: ESL
Language Education
Linguistic Diversity
Name Mispronunciation
Translanguaging
public abstract

description: The purpose of this thesis is to explore occurrences of name mispronunciation, its effects on individuals, and potential remedies to harm incurred within the U.S. educational system. First, existing literature on name mispronunciation, multilingual educational experiences, and translanguaging is explored in a literature review, with specific emphasis on research conducted within classroom or educational settings. Second, data on name mispronunciation, focusing on given names, is collected via a survey to determine clearer connections between name mispronunciation, occurrences of mispronunciation, and relationship to identity and education. Information obtained through the literature review and survey data was analyzed to determine the answers to three main research questions: 1. Do individuals remember occurrences of name mispronunciation, and do these occurrences have a lasting effect? 2. Does name mispronunciation hurt individuals’ relationship to education? 3. What methods of name learning and mispronunciation correction cause the least harm to individuals and shift the onus of pronunciation away from students? From this analysis, it was determined that incidents of name mispronunciation are highly memorable, and respondents were able to recall aspects of them very clearly. Additionally, some respondents reported that having their names mispronounced hurt their relationship both with their teacher and with their educational experience, and also with their name as a feature of their identity, although these findings were inconclusive, as many respondents also reported that the mispronunciation did not cause harm. Finally, by analyzing the differences in the occurrence of name mispronunciations between respondents who did or did not report harm and based upon research on translanguaging explored in the literature review, a recommendation to approach names and the pronunciation of names through the lens of translanguaging was made to educators.
3084329.pdf
Creators: name: Tomasino, Alessandro
name: Mazhorova, Anna
name: Clerici, Matteo
name: Peccianti, Marco
name: Ho, Sze Phing
name: jestin, yoann
name: Pasquazi, Alessia
name: Markov, Andrey
name: Jin, Xin
name: Piccoli, Riccardo
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental document
A knowledge-based environment for the validation of simulation models.
Creators: name: Ozmizrak, Fatma Nur.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Computer Science.

description: A new approach to the validation of simulation models is developed in this thesis. The underlying goal of the approach is to utilize both domain specific knowledge about expected behaviour of the system (typically acquired from a domain expert), and where available, data gathered from an observable system. The approach is knowledge, rather than statistically, based. Behavioural knowledge about the simulation model is formulated in terms of an external specification which is comprised of three disjoint sets of relationships; namely, formal specifications, qualitative specifications and observational specifications. These sets of relationships are developed in a formal context and together they form a knowledge base of validation reference information. A key element in the implementation of a software environment for simulation model validation is the development of an effective means for utilizing the validation reference information. This, in effect, becomes an experiment design problem. Its solution is undertaken in a constraint set framework that evolves from a transformation on the validation reference information. The experiment design problem is thus transformed into a "constraint covering" problem which we refer to as the $C\sp3$ problem (Consistent Constraint Covering). The complexity of the $C\sp3$ problem is analyzed using graph-theoretic concepts. This analysis is based on a new concept that is associated with a set of constraints; namely, a constraint set graph. We explore the relationships between a maximum independent set of a constraint set graph and a simplified version of the $C\sp3$ problem and show its relationship to both the edge cover problem and a set-covering problem. A relationship between the $C\sp3$ problem and the clique cover problem, which is known to be NP-complete, is also shown. An effective approximation algorithm to solve the $C\sp3$ problem is then developed and some of its key properties are explicitly demonstrated. The performance of the algorithm on a set of example problems is included. The thesis establishes a formal general framework for studying the validation problem for simulation models. The $C\sp3$ problem is shown to be a key aspect of the validation problem and the solution to the $C\sp3$ problem which is developed therefore contributes significantly to the solution of the simulation model validation problem.
Distribution and cycling of terrigenous dissolved organic carbon in peatland-draining rivers and coastal waters of Sarawak, Borneo
Creators: name: Martin, Patrick
name: Cherukuru, Nagur
name: Tan, Ashleen S. Y.
name: Sanwlani, Nivedita
name: Mujahid, Aazani
name: Muller, Moritz
Publisher: name: Swinburne
Year: 2024

description: South-East Asia is home to one of the world's largest stores of tropical peatland and accounts for roughly 10% of the global land-to-sea dissolved organic carbon (DOC) flux. We present the first ever seasonally resolved measurements of DOC concentration and chromophoric dissolved organic matter (CDOM) spectra for six peatland-draining rivers and coastal waters in Sarawak, north-western Borneo. The rivers differed substantially in DOC concentration, ranging from 120-250μmolL-1 (Rajang River) to 3100-4400μmolL-1 (Maludam River). All rivers carried high CDOM concentrations, with 350 in the four blackwater rivers between 70 and 210m-1 and 4 and 12m-1 in the other two rivers. DOC and CDOM showed conservative mixing with seawater except in the largest river (the Rajang), where DOC concentrations in the estuary were elevated, most likely due to inputs from the extensive peatlands within the Rajang Delta. Seasonal variation was moderate and inconsistent between rivers. However, during the rainier north-east monsoon, all marine stations in the western part of our study area had higher DOC concentrations and lower CDOM spectral slopes, indicating a greater proportion of terrigenous DOM in coastal waters. Photodegradation experiments revealed that riverine DOC and CDOM in Sarawak are photolabile: up to 25% of riverine DOC was lost within 5 days of exposure to natural sunlight, and the spectral slopes of photo-bleached CDOM resembled those of our marine samples. We conclude that coastal waters of Sarawak receive large inputs of terrigenous DOC that is only minimally altered during estuarine transport and that any biogeochemical processing must therefore occur mostly at sea. It is likely that photodegradation plays an important role in the degradation of terrigenous DOC in these waters.
Competitive intelligence: A self-diagnostic tool applied in the telecom industry.
Creators: name: Thomas, David Jordan.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Business Administration, Management.

description: In collaboration with the University of Ottawa, a toot has been produced to evaluate the Competitive Intelligence Process exercised by a practitioner/team/corporation. Accepted principles of CI (as determined by extensive literature review and consultation with CI experts) have been incorporated into a survey and used to quantify the process as a whole, as well as break down the process into manageable parts and identify specific areas of strength and/or weakness. Face validation of the tool has been demonstrated through its application on four large firms (a sample of convenience) operating in the telecommunications industry. Analysis of strengths and weaknesses of the firm's CI process were highlighted and summarized in a concise report. The capability of the tool for industry characterization was demonstrated, as well as the potential for effective benchmarking against best CI practices. Finally, areas of future focus and development have been highlighted.
title: Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¸Ð½Ð²ÐµÑÑÐ¸ÑÐ¸Ð¾Ð½Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¾ÐµÐºÑÐ° ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ñ ÐÑÑ-ÑÑÑÐ´Ð¸Ð¸ Ð² Ð³.Ð¡ÑÑÐ³ÑÑ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Development of an investment project for the creation of an Art studio in Surgut
Creators: name: Ð¡ÐµÑÐ±Ð¸Ð½Ð°, Ð¯ÑÐ¾ÑÐ»Ð°Ð²Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: Ð±Ð¸Ð·Ð½ÐµÑ-Ð¿Ð»Ð°Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
Ð¾ÑÐµÐ½ÐºÐ° ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸
Ð°Ð½Ð°Ð»Ð¸Ð· ÑÑÐ½ÐºÐ°
Ð°Ð½Ð°Ð»Ð¸Ð· Ð²Ð½ÑÑÑÐµÐ½Ð½ÐµÐ¹ Ð¸ Ð²Ð½ÐµÑÐ½ÐµÐ¹ ÑÑÐµÐ´Ñ
business planning
performance assessment
market analysis
internal and external environment analysis

description: ÐÐ±ÑÐµÐºÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ â ÐÑÑ â ÑÑÑÐ´Ð¸Ñ Â«FreedomÂ» . Ð¦ÐµÐ»Ñ Ð´Ð°Ð½Ð½Ð¾Ð³Ð¾ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ â ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¸Ð½Ð²ÐµÑÑÐ¸ÑÐ¸Ð¾Ð½Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¾ÐµÐºÑÐ°. ÐÐ»Ñ Ð´Ð¾ÑÑÐ¸Ð¶ÐµÐ½Ð¸Ñ Ð¿Ð¾ÑÑÐ°Ð²Ð»ÐµÐ½Ð½Ð¾Ð¹ ÑÐµÐ»Ð¸ Ð½ÐµÐ¾Ð±ÑÐ¾Ð´Ð¸Ð¼Ð¾ ÑÐµÑÐ¸ÑÑ ÑÑÐ´ Ð·Ð°Ð´Ð°Ñ: 1. Ð¡Ð±Ð¾Ñ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ð¾Ð² Ð´Ð»Ñ Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ Ð¸ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð² ÑÐ°Ð±Ð¾ÑÐµ; 2. ÐÐ·ÑÑÐµÐ½Ð¸Ðµ ÑÐ°ÐºÑÐ¾ÑÐ¾Ð² ÑÐ¸ÑÐºÐ° Ð¿ÑÐ¸ ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ð¸ Ð±Ð¸Ð·Ð½ÐµÑ-Ð¿ÑÐ¾ÐµÐºÑÐ°; 3.Ð¥Ð°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸ÐºÐ° ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¸Ñ Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»ÐµÐ¹ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¸; 4. ÐÑÐ´ÐµÐ»Ð¸ÑÑ Ð¼ÐµÑÐ¾Ð´Ñ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ. ÐÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ°Ñ Ð·Ð½Ð°ÑÐ¸Ð¼Ð¾ÑÑÑ ÑÐ°Ð±Ð¾ÑÑ Ð²ÑÑÐ°Ð¶Ð°ÐµÑÑÑ Ð² Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ð¸ Ð²ÑÑÐ²Ð»ÐµÐ½Ð½ÑÑ Ð² ÑÐ¾Ð´Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¼ÐµÑÐ¾Ð´Ð¾Ð² Ð¾ÑÐµÐ½ÐºÐ¸, Ð°Ð½Ð°Ð»Ð¸Ð·Ð° ÑÐ¸ÑÐºÐ¾Ð² Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ Ð¸ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ñ Ð¾ÑÐ½Ð¾Ð²Ð½ÑÑ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ð¹ Ð¿Ð¾Ð²ÑÑÐµÐ½Ð¸Ñ ÐºÐ¾Ð½ÐºÑÑÐµÐ½ÑÐ¾ÑÐ¿Ð¾ÑÐ¾Ð±Ð½Ð¾ÑÑÐ¸. ÐÑÐµÐ½ÐºÐ° Ð¸Ð½Ð²ÐµÑÑÐ¸ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ Ð¿ÑÐ¸Ð²Ð»ÐµÐºÐ°ÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ Ð¿ÑÐ¾ÐµÐºÑÐ° Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸Ð»Ð¾ÑÑ Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ Ð¿Ð°ÐºÐµÑÐ° MS Office (Excel). ÐÑÑÐ¾ÑÐ½Ð¸ÐºÐ°Ð¼Ð¸ Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¸ Ð¿Ð¾ÑÐ»ÑÐ¶Ð¸Ð»Ð¸ Ð´Ð°Ð½Ð½ÑÐµ Ð¾ÑÐµÑÐµÑÑÐ²ÐµÐ½Ð½Ð¾Ð¹ Ð¸ Ð·Ð°ÑÑÐ±ÐµÐ¶Ð½Ð¾Ð¹ Ð½Ð°ÑÑÐ½Ð¾-Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°ÑÐµÐ»ÑÑÐºÐ¾Ð¹ Ð»Ð¸ÑÐµÑÐ°ÑÑÑÑ, Ð¾ÑÐ¸ÑÐ¸Ð°Ð»ÑÐ½ÑÑ ÐÐ½ÑÐµÑÐ½ÐµÑ-ÑÐµÑÑÑÑÐ¾Ð².
description: The object of the study is the Art studio "Freedom". The purpose of this study is to develop an investment project. To achieve this goal, it is necessary to solve a number of tasks: 1. Collection of materials for study and application in the work; 2. Studying risk factors when creating a business project; 3. Characteristics of the economic performance of the organization; 4. Identify the research methods. The practical significance of the work is expressed in the application of the methods of assessment, risk analysis of the enterprise identified during the study and the definition of the main directions for improving competitiveness. The investment attractiveness of the project was assessed using the MS Office (Excel) package. The sources of information were data from domestic and foreign research literature, official Internet resources.
title: Paradoxical attitudes toward premarital dating and sexual encounters in Tehran, Iran
title: a cross-sectional study
titleType: Subtitle
Creators: name: Motamedi, Mahnaz
name: Merghati-Khoei, Effat
name: Shahbazi, Mohammad
name: Rahimi-Naghani, Shahrzad
name: Salehi, Mehrdad
name: Karimi, Mehrdad
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: Sexual attitude
subject: Premarital sex
subject: Virginity
subject: Sexual health
subject: Sexual encounters
subject: 300 Sozialwissenschaften
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background The purpose of this study is to assess attitudes toward premarital dating and sexual encounters in individuals aged 15–49 years in Tehran. Methods Utilizing the attitudes section of an original cross-sectional study (n = 755) aimed at assessing sexual health needs of adults, this paper examined personal attitudes towards premarital dating, non-sexual relationships and sexual encounters in both male and female adults aged between 15–49 years. Multi-stage cluster random sampling and a validated/reliable questionnaire were used. Descriptive, bivariate and multivariate analyses were conducted using statistical software. Results The results indicated that the majority of the participants were supportive of dating. Almost three-fourths of the males were more positively inclined towards non-sexual, yet tactile, affectionate interactions between unmarried males and females as opposed to only half of the females (70 % vs. 50.5 %). Also, males held significantly more liberal attitudes than females in their acceptance of premarital sex. On preserving virginity prior to marriage, 43 % of the males felt that it was important for a female to be a virgin, whereas only 26 % felt it was important for males to remain a virgin. Interestingly, more females (61 %) supported the importance of a female’s virginity compared with the importance of males’ virginity (48 %). This study showed that, being a male, of a younger age, single, and being less religious or being secular were important determinants of a liberal sexual attitude. Conclusion These results might reflect a socio-cultural transition in the sexual attitudes of different age groups of participants - a phenomenon that will need empirical studies to unpack in the Iranian socio-cultural context.
3084329.pdf
Creators: name: Tomasino, Alessandro
name: Mazhorova, Anna
name: Clerici, Matteo
name: Peccianti, Marco
name: Ho, Sze Phing
name: jestin, yoann
name: Pasquazi, Alessia
name: Markov, Andrey
name: Jin, Xin
name: Piccoli, Riccardo
Publisher: name: Optica Publishing Group
Year: 2017
Subjects: Uncategorized

description: Supplemental document
Generation of a human induced pluripotent stem cell line from urinary cells of a healthy donor using integration free Sendai virus technology
Creators: name: Rossbach, Bella
name: Hildebrand, Laura
name: El-Ahmad, Linda
name: Stachelscheid, Harald
name: Reinke, Petra
name: Kurtz, Andreas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: We have generated a human induced pluripotent stem cell (iPSC) line derived from urinary cells of a 28 year old healthy female donor. The cells were reprogrammed using a non-integrating viral vector and have shown full differentiation potential. Together with the iPSC line, the donor provided blood cells for the study of immunological effects of the iPSC line and its derivatives in autologous and allogeneic settings. The line is available and registered in the human pluripotent stem cell registry as BCRTi005-A.
Toward the Directed Evolution of 2'-OMe-RNA Aptamers against Thrombin using Hairpin SELMA
Creators: name: Nair, Malavika Asokan
Publisher: name: Brandeis University
Year: 2028
Subjects: Directed Evolution
Aptamers
SELMA
SELEX
Thrombin

description: The evolution of serum stable RNA aptamers is of great interest for the development of aptamer-based therapeutics. A novel mutant polymerase, KOD DGLNK, can create fully 2’-OMe-modified RNA, which has excellent serum stability. However, reverse transcription of 2’-OMe-RNA presents challenges. To circumvent this, we propose incorporating KOD DGLNK within Hairpin SELMA, a directed evolution platform that avoids reverse transcription. Our aim is to evolve fully 2’-OMe-RNA aptamers towards thrombin and evaluate the efficacy of KOD DGLNK within Hairpin SELMA. In this study, we successfully used SELMA incorporating KOD DGLNK to enrich a random library towards a sequence with known binding affinity. We then conducted 4 rounds of selection towards thrombin; we observed preliminary enrichment in thrombin binders and a convergence in the library to higher melting features. Although additional rounds of selection are necessary to obtain low nanomolar binders of thrombin, our preliminary results demonstrate the potential of KOD DGLNK within Hairpin SELMA as a powerful tool for the evolution of fully modified aptamers.
Spherical near- to far-field estimation from amplitude measurements.
Creators: name: Roczniak, Andrzej M.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Engineering, Electronics and Electrical.

description: Characterizing electromagnetic field produced by radiators in their operational modes is of primordial importance in various engineering application such as antenna design, compatibility and interference testing. The far-field pattern is the most common measure, but it is often impractical and at worst impossible to measure the far-field directly. Numerical methods implementing near- to far-field transformations rely on the knowledge of both the amplitude and phase distribution on a surface in proximity of the device under test. In certain instances however, it is expensive or very difficult to accurately measure the phase distribution component. The intent of this thesis is to investigate the feasibility of near- to far-field transformation with the premise that only amplitude distribution component is available. The requirement is thus to provide, or estimate, the missing information necessary for near- to far-field transformation. The retained approach implements the well known spherical wave expansion technique. The coefficients of the spherical wave functions depend on the boundary conditions, and due to their incomplete knowledge only bounds for those coefficients can be calculated. Application of heuristic methods to the estimation of the coefficients, and upon the assumption of the uniqueness of the solution, are sufficient to predict the radiated fields. This method presents an important advantage over direct phase distribution estimation in that the number of coefficients is well defined and can generally be expected to be less than the required number of phase measurements.
Source_codes
Creators: name: Qian, Yuehui
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 460605
subject: Distributed systems and algorithms
classificationCode: 490412
subject: Topology
classificationCode: 401302
subject: Geospatial information systems and geospatial data modelling

description: Terrain topology plays an important role in simulations and segmentation. A widely used terrain representation is the Triangulated Irregular Network (TIN). However, topological analysis on TINs is challenging due to high time and memory requirements, which limit the size of the terrain that can be analyzed.
We address this problem by introducing a novel framework for efficient and scalable analysis of large TINs based on Morse theory using Apache Spark. The proposed framework, named Morse-Spark, is based on a novel data structure for encoding the minimal information of a TIN, and integrates efficient algorithms for computing terrain morphology. To evaluate the effectiveness and scalability of such a framework, we compare Morse-Spark against a vanilla Spark implementation and three well-established software libraries for the topological analysis of TINs through a comprehensive set of experiments. Our experimental evaluation with real-world TINs shows that Morse-Spark can effectively handle datasets at least 20 times larger than existing approaches.
Re-examining the law-making power in the Canadian Constitution: A case for a non-delegation doctrine.
Creators: name: McMurray, Diane.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Law.

description: This thesis argues that there is a limited separation of powers in the Canadian Constitution between the executive and legislative branches. The fundamental nature of the Constitution Act, 1867 which commits the law-making power to elected legislatures demands that those bodies be prohibited from delegating their primary legislative powers to the executive. Judicial tolerance of such delegation flows from the unexamined assumption that as with the British constitution, the pivotal principle of our Constitution is parliamentary supremacy. It is not. Furthermore, such tolerance is troublesome in view of the fact that in constitutional practice today, cabinet controls Parliament. Canadian courts have the tools to develop a non-delegation doctrine that would insist that only legislatures could enact new laws or change existing ones. Such a doctrine would uphold the Constitution and ensure that all primary legislation be subject to the democratic safeguards provided by the rules of parliamentary procedure.
On the characterization of the viscoelastic response of a class of materials using acousto-ultrasonics: A pattern recognition approach.
Creators: name: Iyer, Srinivasan.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1993
Subjects: subject: Engineering, Mechanical.

description: This thesis describes the experimental work carried out at the University of Ottawa for characterizing linear viscoelastic materials using acousto-ultrasonic wave propagation technique. The objective of the research program is to asses the feasibility of utilizing acousto-ultrasonics in the characterization of mechanical response and strength prediction of solid polymers as a class of engineering materials. The basic principles of acousto-ultrasonic technique, the instrumentation involved, and the factors affecting waveform measurements are described. A review on the analysis of the resultant acousto-ultrasonic waveform using statistical pattern recognition methodology is presented. The time-dependent properties of creep, and stress-relaxation of linear viscoelastic materials are reviewed. Also, fatigue, macromechanical defects and yielding of polymers are discussed. Experimental results obtained in a series of acousto-ultrasonic characterization tests performed on Polyvinylchloride (PVC) and Polycarbonate (PC) specimens are presented. Good correlation was obtained between the acousto-ultrasonic parameter (AUP) and stress in material during a time-dependent stress relaxation testing for a particular strain level. The acousto-ultrasonic parameter (AUP) was seen to decrease with increasing stress levels during uniaxial tensile loading. Also, induced fatigue states in the material and macromechanical defect states were seen to have good correlation with the AUP. Statistical pattern recognition classifiers were designed for all characterization experiments performed and tested with unknown samples and found to be very effective. Acousto-Ultrasonics (AU), combined with statistical pattern recognition methodology applied in real time environment, proves to be an efficient non-destructive quantitative evaluation process for the class of solid polymers investigated.
A Monte Carlo study of the robustness of coefficient alpha.
Creators: name: Shultz, Sharon G.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1993
Subjects: subject: Statistics.

description: The biasedness and efficiency of coefficient alpha were studied given various error score distribution, number of examinees, population reliability values, and number of subtests. A Monte Carlo methodology was used in which an additive true score matrix was constructed and an error score was added to each true score. The true scores were uniformly distributed while the error score distributions used were the normal, mixed normal, exponential, and the negative exponential. In addition, 1000 replications were used and the resulting sampling distributions were examined with respect to their skewness and kurtosis. The results indicated that, when 50, 100, and 200 examinees and 5, 10, 20, and 30 subtests were used, coefficient alpha was an unbiased estimator of population reliability values of 0.4, 0.6, 0.8, and 0.9. The efficiency of the estimate increased as the number of examinees or the population reliability increased, regardless of the error score distribution used. Of the four error score distributions used the normal was the most efficient. In addition, the sampling distributions tended to become less skewed and more leptokurtic as the number of examinees and the population reliability increased. Surprisingly, an increase in the number of subtests did not appear to affect the biasedness and efficiency of coefficient alpha or the skewness and kurtosis of its sampling distribution. The results are related to the literature and suggestions for future study are given.
What We Talk about When We Talk about Unconscious Processing – A Plea for Best Practices
Creators: name: Rothkirch, Marcus
name: Hesselmann, Guido
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: consciousness
subject: awareness
subject: unconscious processing
subject: best practices, diversity
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: In this perspective article, we first outline the large diversity of methods, measures, statistical analyses, and concepts in the field of the experimental study of unconscious processing. We then suggest that this diversity implies that comparisons between different studies on unconscious processing are fairly limited, especially when stimulus awareness has been assessed in different ways. Furthermore, we argue that flexible choices of methods and measures will inevitably lead to an overestimation of unconscious processes. In the concluding paragraph, we briefly present solutions and strategies for future research. We make a plea for the introduction of “best practices,” similar to previous attempts to constitute practicing standards for functional magnetic resonance imaging (fMRI) and electroencephalography (EEG).
A study to develop and validate a clinical prediction rule to exclude pulmonary embolism.
Creators: name: Rodger, Marc.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Health Sciences, Medicine and Surgery.

description: Statement of the problem. Pulmonary Embolism (PE) is a common, lethal and treatable condition that is only present in a minority of those investigated with suspected PE. A clinical prediction rule that safely excludes PE could avert the need for many expensive diagnostic tests and improve patient management. Methods. Phase I - Using univariate techniques potential predictor variables were identified from a prospective cohort study of patients with suspected PE who subsequently had outcomes measured (Derivation set). Phase II - The inter-observer reliability of these individual predictor variables were determined in a second prospective cohort study of patients with suspected PE (Inter-observer reliability study). Phase III - Two multivariate techniques (recursive partitioning and logistic regression) were used to derive clinical prediction rules in the derivation set based on those variables that were both significant in univariate analysis (p < 0.20) (Phase I) and had good inter-observer reliability (kappa > 0.5) (Phase II). The clinical prediction rule with the highest specificity with close to 100% sensitivity was then identified using classification analysis in the derivation set. Phase IV - The rule was then retrospectively validated in a third dataset from a previously published prospective cohort study of patients with suspected PE (Validation set). (Abstract shortened by UMI.)
Molecular mechanisms contributing to the expression of utrophin at the mammalian neuromuscular synapse.
Creators: name: Gramolini, Anthony O.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Biology, Neuroscience.

description: Duchenne muscular dystrophy (DMD) is the most severe and prevalent primary myopathy. This disease is characterized by repeated cycles of muscle fiber degeneration and regeneration with an eventual failure to regenerate leading to the progressive replacement of myofibers by adipose and connective tissues. The genetic defects responsible for DMD are mutations in the short arm of the X chromosome which prevent the production of normal size dystrophin, a large cytoskeletal protein of 427 kDa. In contrast to the homogeneous distribution of dystrophin along muscle fibers, utrophin preferentially accumulates at the neuromuscular junction. Due to this sequence similarity between dystrophin and utrophin, it has been suggested that increased expression of utrophin into extrasynaptic regions of dystrophic muscle fibers may represent a therapeutic strategy for DMD. Recently, it has been confirmed that the upregulation of utrophin can, indeed, functionally compensate for the lack of dystrophin and alleviate the muscle pathology. In this context, it thus becomes essential to determine the cellular and molecular mechanisms presiding over utrophin expression in attempts to overexpress the endogenous gene product throughout skeletal muscle fibers. In this Thesis, I explore the mechanisms underlying the selective accumulation of utrophin at the postsynaptic membrane of the neuromuscular synapse. We determined by in situ hybridization that local transcription contributes to the accumulation of utrophin at the neuromuscular junction. Using direct injections of utrophin promoter-reporter constructs into skeletal muscle, we also defined the promoter elements involved in this local transcription and determined that the N-box element is a key consensus sequence that directs transcriptional control of utrophin expression at the neuromuscular junction. Furthermore, additional experiments revealed that utrophin gene transcription is dependent on the extracellular matrix proteins agrin and ARIA/heregulin, and this regulation is dependent upon the N-box element. Indeed, in vitro transfection assays and electromobility shift assays indicated that agrin and ARIA/heregulin may ultimately initiate a cell signaling cascade that activates the ETS-related transcription factor, GA-binding protein (GABP) which binds and activates the N-box element. In these experiments, we determined by RT-PCF, immunoblotting, and nuclear run on assays that, in contrast to the large changes in AChR, utrophin expression was only marginally increased under these conditions. (Abstract shortened by UMI.)
Exploring the scalability and sustainability of community-based agroforestry to achieve planetary health benefits in Haiti’s Lower Artibonite Valley
Creators: name: Blaise, Gloria C.
name: Sprenkle-Hyppolite, Starry
name: Allred, Shorna B.
name: Jagadish, Arundhati
name: Meredith, Genevive R.
name: Constas, Mark A.
name: Buck, Louise E.
name: Morreale, Stephen J.
Publisher: name: Public Library of Science
Year: 2024

description: Community-based agroforestry, as a planetary health solution, can rebuild fertile soils, minimize climate risk, diversify farmer incomes, and provide a source of food, raw materials, and other vital ecosystem functions. Utilizing focus groups, individual semi-structured interviews, and field observations, we studied how the Haiti Timber Reintroduction Program (HTRIP), an agroforestry program operating in Haiti since 2005, leveraged institutional infrastructures and social networks to facilitate the adoption, scaling, and sustainability of community-based agroforestry as a solution for planetary health. Results show that the adoption and scaling of community-based agroforestry was facilitated by support from institutional and social networks. The results underscore the importance of cross-sector collaboration and coordination in creating the enabling conditions necessary for successful community-based agroforestry implementation. Additionally, strengthened social networks, cultivated through long-term participation in the HTRIP, contributed to the program’s sustainability. While competing socio-political problems in some low-income settings may seem insurmountable—particularly those in fragile states, where our study took place—our research demonstrates that community-based agroforestry solutions are possible. Where culturally relevant, this ecologically and socially based practice could be scaled up to amplify its benefits to more communities. We encourage further research to explore the scaling up of regenerative practices such as agroforestry for climate resilience and planetary health.
Women's decisions and decisional conflict regarding long term hormone replacement therapy.
Creators: name: Wood, Elizabeth.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Health Sciences, Obstetrics and Gynecology.

description: Long term preventive hormone replacement therapy (LTP-HRT) is attracting considerable attention for its potential in reducing the incidence of coronary heart disease and osteoporosis associated fractures in post-menopausal women. The study objectives were: (1) to describe women's decisions and decisional conflict regarding LTP-HRT after being presented with the evidence of benefits and risks and clarifying values; (2) to describe the difference between those who accept or decline LTP-HRT in terms of: (a) expectations of LTP-HRT benefits and risks, and (b) the importance women attach to the benefits and the risks; and (3) to describe the factors women identify as contributing to their decision to take or not take LTP-HRT or being unsure about taking LTP-HRT. The typical woman who participated in the study was 57 years of age; had some post secondary education; and was currently using HRT. Over half the women had at least one CHD risk factor and had a hysterectomy. Less than 15% of the respondents reported having osteoporosis or a first degree relative with breast cancer. Women's decisions to take LTP-HRT were distributed as follows: 56% yes; 26% no; and 18% unsure. Women who accepted or declined LTP-HRT did not have statistically significant differences in expectations of risk of CHD, osteoporosis, and breast cancer with and without hormone therapy. In contrast, women's importance ratings of LTP-HRT benefits and side effects did differ significantly between those accepting and declining LTP-HRT. The reasons most often identified by women who chose LTP-HRT were prevention of CHD and osteoporosis (61%) and relief of hot flashes (54%). Those who chose not to take LTP-HRT gave reasons such as dislike of taking pills (47%), and risk of cancer (11%). (Abstract shortened by UMI.)
Acceptability and design preferences of supervised injection services among people who inject drugs in a mid-sized Canadian City
Creators: name: Mitra, Sanjana
name: Rachlis, Beth
name: Scheim, Ayden
name: Bardwell, Geoff
name: Rourke, Sean B
name: Kerr, Thomas
Publisher: name: BioMed Central
Year: 2017

description: Background: Supervised injection services (SIS) have been shown to reduce the public- and individual-level harms associated with injection drug use. While SIS feasibility research has been conducted in large urban centres, little is known about the acceptability of these services among people who inject drugs (PWID) in mid-sized cities. We assessed the prevalence and correlates of willingness to use SIS as well as design and operational preferences among PWID in London, Canada. Methods: Between March and April 2016, peer research associates administered a cross-sectional survey to PWID in London. Socio-demographic characteristics, drug-use patterns, and behaviours associated with willingness to use SIS were estimated using bivariable and multivariable logistic regression models. Chi-square tests were used to compare characteristics with expected frequency of SIS use among those willing to use SIS. Design and operational preferences are also described. Results: Of 197 PWID included in this analysis (median age, 39; interquartile range (IQR), 33–50; 38% female), 170 (86%) reported willingness to use SIS. In multivariable analyses, being female (adjusted odds ratio (AOR) 0.29; 95% confidence interval (CI) 0.11–0.75) was negatively associated with willingness to use, while public injecting in the last 6 months (AOR 2.76; 95% CI 1.00–7.62) was positively associated with willingness to use. Participants living in unstable housing, those injecting in public, and those injecting opioids and crystal methamphetamine daily reported higher expected frequency of SIS use (p < 0.05). A majority preferred private cubicles for injecting spaces and daytime operational hours, while just under half preferred PWID involved in service operations. Conclusions: High levels of willingness to use SIS were found among PWID in this setting, suggesting that these services may play a role in addressing the harms associated with injection drug use. To maximize the uptake of SIS, programme planners and policy makers should consider the effects of gender and views of PWID regarding SIS design and operational preferences.
title: Ð¤Ð¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ ÑÐ°ÑÐ¸ÑÐ¾Ð² Ð½Ð° ÑÐ½ÐµÑÐ³Ð¸Ñ Ð¼ÐµÑÐ¾Ð´Ð¾Ð¼ Ð¸Ð½Ð´ÐµÐºÑÐ°ÑÐ¸Ð¸ Ð´Ð»Ñ ÑÐ»ÐµÐºÑÑÐ¾ÑÑÐ°Ð½ÑÐ¸Ð¹, ÑÐ°Ð±Ð¾ÑÐ°ÑÑÐ¸Ñ Ð½Ð° Ð¾Ð¿ÑÐ¾Ð²Ð¾Ð¼ ÑÑÐ½ÐºÐµ ÑÐ½ÐµÑÐ³Ð¸Ð¸ Ð¸ Ð¼Ð¾ÑÐ½Ð¾ÑÑÐ¸ (Ð½Ð° Ð¿ÑÐ¸Ð¼ÐµÑÐµ ÐÐÐ Â«Ð¢ÐÐ-1Â»)
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Formation of energy tariffs by indexing for power plants operating in the wholesale energy and capacity market (using the example of PJSC TGC-1)
Creators: name: Ð¡Ð°Ð¼Ð¾ÑÐµÐ½ÐºÐ¾Ð²Ð°, ÐÑÐ¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: ÑÐ°ÑÐ¸ÑÐ½Ð¾Ðµ ÑÐµÐ½Ð¾Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ðµ
Ð¼ÐµÑÐ¾Ð´ Ð¸Ð½Ð´ÐµÐºÑÐ°ÑÐ¸Ð¸
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Ð¢ÐÐ
Ð Ð¡Ð
ÐÐ Ð­Ð
tariff pricing
indexing method
RD
TGC
RSV
OREM

description: ÐÑÐ»Ð¸ ÑÐµÑÐµÐ½Ñ ÑÐ»ÐµÐ´ÑÑÑÐ¸Ðµ Ð·Ð°Ð´Ð°ÑÐ¸: â¯ Ð¸Ð·ÑÑÐµÐ½Ñ ÑÐµÐ¾ÑÐµÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð¾ÑÐ½Ð¾Ð²Ñ ÐÐ Ð­Ð; â¯ Ð¿ÑÐ¾Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð° Ð¼ÐµÑÐ¾Ð´Ð¸ÐºÐ° ÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÑÐ°ÑÐ¸ÑÐ¾Ð² Ð² ÑÐµÐºÑÐ¾ÑÐµ Ð Ð; â¯ Ð¸Ð·ÑÑÐµÐ½Ñ Ð¼ÐµÑÐ¾Ð´Ñ Ð¸Ð½Ð´ÐµÐºÑÐ°ÑÐ¸Ð¸ ÑÐ°ÑÐ¸ÑÐ¾Ð²; â¯ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½ ÑÐ°ÑÑÐµÑ ÑÐ°ÑÐ¸ÑÐ½ÑÑ ÑÑÐ°Ð²Ð¾Ðº Ð½Ð° 2025 Ð³Ð¾Ð´. Ð¦ÐµÐ»ÑÑ ÑÐ°Ð±Ð¾ÑÑ ÑÐ²Ð»ÑÐµÑÑÑ Ð¸Ð·ÑÑÐµÐ½Ð¸Ðµ ÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÑÐ°ÑÐ¸ÑÐ¾Ð² Ð½Ð° ÑÐ½ÐµÑÐ³Ð¸Ñ Ð¼ÐµÑÐ¾Ð´Ð¾Ð¼ Ð¸Ð½Ð´ÐµÐºÑÐ°ÑÐ¸Ð¸ Ð´Ð»Ñ ÑÐ»ÐµÐºÑÑÐ¾ÑÑÐ°Ð½ÑÐ¸Ð¹, ÑÐ°Ð±Ð¾ÑÐ°ÑÑÐ¸Ñ Ð½Ð° Ð¾Ð¿ÑÐ¾Ð²Ð¾Ð¼ ÑÑÐ½ÐºÐµ ÑÐ½ÐµÑÐ³Ð¸Ð¸ Ð¸ Ð¼Ð¾ÑÐ½Ð¾ÑÑÐ¸, Ð¸Ð·ÑÑÐµÐ½Ð¸Ð¸ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð¼ÐµÑÐ¾Ð´Ð° ÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÑÐ°ÑÐ¸ÑÐ¾Ð² Ð´Ð»Ñ Ð¾Ð±ÐµÑÐ¿ÐµÑÐµÐ½Ð¸Ñ ÐºÐ¾Ð½ÐºÑÑÐµÐ½ÑÐ¾ÑÐ¿Ð¾ÑÐ¾Ð±Ð½Ð¾ÑÑÐ¸ ÐºÐ¾Ð¼Ð¿Ð°Ð½Ð¸Ð¹ Ð¸ Ð´Ð¾ÑÑÑÐ¿Ð½Ð¾ÑÑÐ¸ Ð½Ð°Ð´ÐµÐ¶Ð½Ð¾Ð³Ð¾ ÑÐ½ÐµÑÐ³Ð¾ÑÐ½Ð°Ð±Ð¶ÐµÐ½Ð¸Ñ Ð¿Ð¾ÑÑÐµÐ±Ð¸ÑÐµÐ»ÑÐ¼ ÑÐµÑÐµÐ· Ð°Ð½Ð°Ð»Ð¸Ð· ÐµÐ³Ð¾ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð² ÑÐµÐ³Ð¼ÐµÐ½ÑÐµ ÑÐµÐ³ÑÐ»Ð¸ÑÑÐµÐ¼ÑÑ Ð´Ð¾Ð³Ð¾Ð²Ð¾ÑÐ¾Ð².
description: The following tasks were solved: â¯ the theoretical foundations of the OREM have been studied; â¯ the methodology of tariff formation in the RD sector is analyzed; â¯ methods of tariff indexing have been studied; â¯ the calculation of tariff rates for 2025 has been carried out. The purpose of the work is to study the formation of energy tariffs by the indexation method for power plants operating in the wholesale energy and capacity market, to study the application of the tariff formation method to ensure the competitiveness of companies and the availability of reliable energy supply to consumers through the analysis of its application in the segment of regulated contracts.
Technologies for Pesticides Removal: Decontamination of Apples and Apple By-Products for Food Applications
Creators: name: Gasparini, Alessandra
name: Morozova, Ksenia
name: Scampicchio, Matteo
name: Ferrentino, Giovanna
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Pesticides are essential for protecting crops from diseases, but their residues on fruits raise concerns about food safety and human health. They are broadly classified into systemic pesticides, which are primarily hydrophilic and penetrate plant tissues, and non-systemic pesticides, which are predominantly lipophilic and remain on the surface. These chemical properties influence their persistence in apples and determine the effectiveness of different removal strategies. Extensive research has been dedicated to develop and optimize technologies to effectively reduce pesticide residues in apples and apple-based products. Indeed, the removal of pesticides is a key factor in the sustainable valorization of apple by-products, unlocking new opportunities for their safe and functional use in food applications. This review provides an overview of the principal techniques employed for pesticide removal from apples and their by-products. After outlining the main pesticides used in apple cultivation and their mode of action, novel processing technologies and their effects on pesticides removal have been described. The relationship between pesticides properties and the efficacy of the applied technologies is also evaluated along with the advantages and disadvantages of each treatment. Finally, the review provides strategies to enhance the safety and quality of apple-derived ingredients, emphasizing their potential integration into food systems.