cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A Systematic Review of the Predictive Validity of Neurobehavioral Assessments During the Preterm Period
Creators: name: Craciunoiu, Oana
name: Holsti, Liisa
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology

description: Aims: For high-risk newborns, early assessment of neurobehavior that accurately predicts neurodevelopmental outcome is the first step towards determining early intervention needs. This study reviews systematically the validity of neurobehavioral assessments administered to premature newborns before term-equivalent age to predict long-term neurodevelopmental outcome. Methods: A systematic literature search of CINAHL, EMBASE, MEDLINE, PubMed, Web of Science, PsychInfo, Cochrane Library databases was conducted. PRISMA and COSMIN guidelines were followed. Results: Five assessments and 11 studies were identified: (a) Neonatal Behavioral Assessment Scale (NBAS); (b) Test of Infant Motor Performance (TIMP); (c) General Movements (GMs); (d) Neurobehavioral Assessment of the Preterm Infant (NAPI); (e) Neonatal Oral Motor Assessment Scale (NOMAS). Predictive validity estimates were variable. The GMs and TIMP showed the strongest associations with neurodevelopmental outcome. Threats to validity included small sample size, sample bias, limited reliability testing. Conclusions: Five neurobehavioral measures have established predictive validity for the assessment of premature newborns while they reside in the NICU. Although the GMs and TIMP have the strongest evidence, further higher quality research is required. New methods of testing should be developed that provide accurate prediction and minimize the potential stress induced during developmental assessments.
Que professor investigador? para uma (possível) resposta, análise de relatórios de estágio de futuros docentes
Creators: name: Duarte, Pedro
name: Moreira, Ana Isabel
Publisher: name: CIED - Centro Interdisciplinar de Estudos Educacionais
Year: 2020

description: Partindo da premissa que sugere que um professor é também um investigador, este artigo pretende explorar essa ‘faceta profissional’, mas a partir da experiência de alguns estudantes aquando da frequência de um mestrado profissionalizante para a docência. Para tal, e recorrendo ao programa informático MAXQDA 2018, analisamos o conteúdo de 25 relatórios de estágios de alunos do Mestrado em Educação Pré-Escolar e Ensino do 1.º Ciclo do Ensino Básico selecionados aleatoriamente, tendo atentado em elementos vários, como as temáticas educativas investigadas, as motivações subjacentes às pesquisas ou a concertação entre os pressupostos metodológicos assumidos e os objetivos de investigação definidos. No final, duas ou três considerações ganharam destaque: aqueles futuros docentes, para além de vivenciarem um momento elementar para o desenvolvimento da sua literacia investigativa, reconhecendo as várias dimensões inerentes ao processo, nem sempre são capazes de discernir a prática investigativa da prática pedagógica ou, ainda, distintos métodos de investigação.
description: Da Investigação às Práticas: Estudos de Natureza Educacional, v. 10, n. 1 (2020)
Desenvolvimento lexical no 1º ano de escolaridade: um percurso didático
Creators: name: Alegria, Vânia Rita
Publisher: name: CIED - Centro Interdisciplinar de Estudos Educacionais
Year: 2020

description: O desenvolvimento lexical está diretamente relacionado com a capacidade de compreensão e produção do significado não só ao nível da palavra, ou item lexical, mas também no domínio da dimensão textual. Assim sendo, cabe à escola a tarefa de estimular e promover o desenvolvimento da consciência lexical de modo a aumentar as capacidades linguísticas dos alunos. O presente estudo tem como objetivos: (i) caracterizar as competências dos alunos ao nível da definição verbal; (ii) implementar um percurso didático numa turma do 1º ano, do 1º Ciclo; (iii) avaliar a eficácia da intervenção didática realizada no desenvolvimento da definição verbal dos alunos. Para dar resposta aos objetivos delineados, procedeu-se à conceção e implementação de um projeto de intervenção numa turma de 1º ano do 1º Ciclo do Ensino Básico, da margem sul de Lisboa. A planificação da intervenção contempla a aplicação de um pré-teste de definição verbal (Sim-Sim, 2014) e a intervenção didática em sala de aula, seguida de um pós-teste de definição verbal, de forma a poder avaliar os resultados da intervenção. Os resultados desta investigação mostram que o desenho de um percurso didático, ancorado nos princípios da abordagem ativa de descoberta e concebido para despoletar a atividade metalinguística dos alunos no domínio da consciência lexical, pode ser um fator de desenvolvimento lexical, o que na linha da literatura da especialidade é indicado como potenciador do aumento de competências de literacia.
description: Da Investigação às Práticas: Estudos de Natureza Educacional, v. 10, n. 1 (2020)
Effects of soybean cropping on arthropods
Creators: name: Amthauer Gallardo, Leonardo
name: Dauber, Jens
Publisher: name: Zenodo
Year: 2022
Subjects: cropdiversity
arthropods
biodiversity

description: The decline in the diversity and biomass of arthropods, insects in particular, in agricultural landscapes poses a major challenge to agriculture. There is little evidence about the effect of introducing grain legumes into cropping systems on this group of organisms. In a review of the international literature, we found that, except for soybean, there is almost no information on the impact of grain legumes on arthropod diversity and activity density. A quantitative analysis of the available information on soybean showed that soybean crops have a greater activity density and species richness of arthropods compared to other arable crops such as maize and wheat. Against the background of the critical state of agroecosystem biodiversity, we conclude that the introduction of soybean into cropping systems otherwise dominated by cereals is unlikely to cause a further decline in arthropods with the likelihood of some gains.
Editorial
Creators: name: Ferreira, Nuno Martins
Publisher: name: CIED - Centro Interdisciplinar de Estudos Educacionais
Year: 2020

description: Sobretudo em tempos conturbados, é bom contar com aquilo que nos traz algum ânimo. Neste número da Revista, reúnem-se alguns artigos que possibilitam passar por diferentes áreas, estando todas, como seria de esperar, ligadas à educação e ao conhecimento. Os primeiros três artigos abordam temas da área da língua portuguesa. O primeiro foca o desenvolvimento lexical e a importância de a escola estimular e promover o desenvolvimento da consciência lexical dos alunos para assim se aumentar as suas capacidades linguísticas e outras. O segundo artigo deixa vislumbrar os diálogos que se podem estabelecer entre a didática da língua materna e a metodologia de trabalho de projeto, assumindo-se que há uma relação biunívoca entre ambas. No terceiro artigo, discorre-se sobre o género gramatical no nome e sobre o modo como o assunto é tratado nos documentos orientadores e em diversos manuais. Fica a ideia de nem sempre haver harmonia no que respeita ao tratamento deste tópico. Sabemos que o papel que a investigação assume na vida do professor é cada vez mais importante. Por isso, é determinante tentar perceber como é que um futuro professor se posiciona como investigador. Este é o tema do quarto artigo. De um contexto nacional, passamos para um contexto internacional, com um artigo sobre a formação contínua de professores de português do Ensino Básico em São Tomé e Príncipe, mais concretamente, com uma proposta de oficina de formação sobre ensino e avaliação da escrita. O número encerra com um estudo sobre as atitudes de alunos do 6.º ano relativamente à matemática, destacando-se a importância de materiais e estratégias para a motivação dos alunos. Na verdade, é sobejamente conhecido o papel que a motivação assume não só na área da educação, mas na vida em geral. Possamos então aproveitar todos estes artigos e ideias para motivar, para inovar, para descobrir e para conhecer.
description: Da Investigação às Práticas: Estudos de Natureza Educacional, v. 10, n. 1 (2020)
Flavonoid and phenolic acid profile by LC-MS/MS and biological activity of crude extracts from Chenopodium hybridum aerial parts
Creators: name: I. Podolak
name: M. Olech
name: A. Galanty
name: D. Załuski
name: K. Grabowska
name: D. Sobolewska
name: M. Michalik
name: R. Nowak
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology

description: Extracts from leaves and stems of Chenopodium hybridum were characterised for the presence and quantity of flavonoids and phenolic acids by LC-ESI-MS/MS. Five flavonoids and eight phenolic acids were detected for the first time in aerial parts of this plant species, the most abundant compounds being rutin (2.80 μg/g DW), 3-kaempferol rutinoside (2.91 μg/g DW), 4-OH-benzoic (1.86 μg/g DW) and syringic acids (2.31 μg/g DW). Extracts were tested for anti-inflammatory/antiarthritic, antihyaluronidase and cytotoxic activities against human prostate cancer (Du145, PC3) and melanoma cell lines (A375, HTB140 and WM793) of different malignancy. None of the extracts protected bovine serum albumin from heat-induced denaturation. Antihyaluronidase effect at the tested concentration was higher than standard naringenin. Cytotoxic activity was generally low with an exception of the extract from the leaves, which was found most effective against prostate Du145 cell line with 98.28 ± 1.13% of dead cells at 100 μg/mL.
Numerical simulation of hypersonic laminar flow over a blunt cone flare
Creators: name: Chen, Chuwei
Publisher: name: No Publisher Supplied
Year: 2022

description: For assessment of CFD capability in the prediction of the aerothermodynamic loading on a hypersonic shock wave boundary layer interaction (SWBLI) region, the numerical simulation of hypersonic laminar flow over a blunt cone flare configuration is performed using the perfect gas laminar Navier-Stokes equations. Computational results are compared with experimental data measured by Infrared Thermography technology from the US Air Force Research Lab's Mach 6 Ludwieg Tube wind tunnel. Heat transfer data from the simulation agrees well with the experiment upstream of the SWBLI region but the separation zone is overpredicted in all computational cases, suggesting that the experimental data does not converge to steady state.
Effects of treatments with Apivar® and Thymovar® on V. destructor populations, virus infections and indoor winter survival of Canadian honey bee (Apis mellifera L.) colonies
Creators: name: Naggar, Yahya Al
name: Tan, Yang
name: Rutherford, Colton
name: Connor, Wayne
name: Griebel, Philip
name: Giesy, John P.
name: Robertson, Albert J.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology

description: Efficacies of two miticides, Apivar® and Thymovar®, were evaluated as a fall treatment against V. destructor. The effect of treatment with miticides was further evaluated by monitoring both viral load and rate of indoor overwintering survival of colonies of European honey bees (Apis mellifera L.) in the vicinity of Saskatoon, Saskatchewan, Canada. Forty-five colonies were randomly assigned to three treatment groups with 15 hives per group: Group 1; 2 strips of Thymovar® (thymol); Group 2; 2 strips of Apivar® (Amitraz); and Group 3; no treatment (control). Significant decreases in the rates of colony infestation (Mites per hundred bees, MPHB) by V. destructor were observed (p ® in October 2013 when compared to control colonies. Efficacy of Apivar® and Thymovar® against V. destructor after treatment for 22 days were 76.5 and 26.7%, respectively. After 22 days, concentrations of the two miticides in bees were 15.4 ng amitraz/g wet mass (wm) and 64,800 ng thymol/g wm. There were no significant differences (p > 0.05) in the percentage of colonies infected by deformed wing virus (DWV) and Israeli acute paralysis virus (IAPV) either before or after treatment with Apivar® or Thymovar® in October 2013 and 7 months post treatment in April 2014. Only the Apivar® treatment group showed IAPV infections in April 2014. The group treated with Apivar® exhibited a better overwintering rate of survival (93%), than hives treated with Thymovar® (67%). These results suggest volatile miticides like Thymovar® should be avoided in geographical areas with colder fall temperatures.
Covalent allosteric inhibitors of Akt generated using a click fragment approach
Creators: name: Westhuizen, Leandi Van Der
name: Weisner, Jörn
name: Taher, Abu
name: Landel, Ina
name: Quambusch, Lena
name: Lindemann, Marius
name: Uhlenbrock, Niklas
name: Müller, Matthias P.
name: Green, Ivan R.
name: Pelly, Stephen C.
name: Rauh, Daniel
name: Otterlo, Willem A. L. Van
Publisher: name: TU Dortmund
Year: 2022
Subjects: subject: Akt kinase
subject: covalent allosteric inhibitors
subject: imidazopyridines
subject: click chemistry
subject: fragments
subject: 570
subject: 540
subject: Protein-Serin-Threonin-Kinasen
subject: Allosterische Kontrolle
subject: Imidazopyridine
subject: Click-Chemie
subject: Inhibitor

description: Akt is a protein kinase that has been implicated in the progression of cancerous tumours. A number of covalent allosteric Akt inhibitors are known, and based on these scaffolds, a small library of novel potential covalent allosteric imidazopyridine-based inhibitors was designed. The envisaged compounds were synthesised, with click chemistry enabling a modular approach to a number of the target compounds. The binding modes, potencies and antiproliferative activities of these synthesised compounds were explored, thereby furthering the structure activity relationship knowledge of this class of Akt inhibitors. Three novel covalent inhibitors were identified, exhibiting moderate activity against Akt1 and various cancer cell lines, potentially paving the way for future covalent allosteric inhibitors with improved properties.
description: ChemMedChem;17(10)
Synthesis and characterization of cationic hydrogels from thiolated copolymers for independent manipulation of mechanical and chemical properties of cell substrates
Creators: name: Pätzold, Florian
name: Stamm, Nils
name: Kamps, Dominic
name: Specht, Maria
name: Bolduan, Patrick
name: Dehmelt, Leif
name: Weberskirch, Ralf
Publisher: name: TU Dortmund
Year: 2022
Subjects: subject: cell adhesion
subject: COS7 cell
subject: hydrogel
subject: Michael reaction
subject: precursor polymer
subject: 540
subject: Zelladhäsion
subject: Hydrogel
subject: Michael-Addition
subject: Präkursor
subject: Polymere

description: Cells sense both mechanical and chemical properties in their environment and respond to these inputs with altered phenotypes. Precise and selective experimental manipulations of these environmental cues require biocompatible synthetic materials, for which multiple properties can be fine-tuned independently from each other. For example, cells typically show critical thresholds for cell adhesion as a function of substrate parameters such as stiffness and the degree of functionalization. However, the choice of tailor-made, defined materials to produce such cell adhesion substrates is still very limited. Here, a platform of synthetic hydrogels based on well-defined thiolated copolymers is presented. Therefore, four disulfide crosslinked hydrogels of different composition by free radical polymerization are prepared. After cleavage with dithiothreitol, four soluble copolymers P1–P4 with 0–96% cationic monomer content are obtained. P1 and P4 are then combined with PEGDA3500 as a crosslinker, to fabricate 12 hydrogels with variable elasticity, ranging from 8.1 to 26.3 kPa and cationic group concentrations of up to 350 µmol cm−3. Systematic analysis using COS7 cells shows that all of these hydrogels are nontoxic. However, successful cell adhesion requires both a minimal elasticity and a minimal cationic group concentration.
description: Macromolecular bioscience;22(5)
title: La (f)utilité gouvernementale de l’évaluation des politiques publiques, quelques leçons américaines et françaises (LIEPP Working Paper, n°49)
Creators: name: Spenlehauer, Vincent
Publisher: name: Sciences Po - LIEPP
Year: 2016
Subjects: subject: FOS: Social sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: La présente contribution rassemble un certain nombre de résultats d’études et d’observations, américaines en majorité, concernant l’impact gouvernemental des évaluations des politiques publiques.
Techno-economic evaluation of simultaneous arsenic and fluoride removal from synthetic groundwater by electrocoagulation process: optimization through response surface methodology
Creators: name: Lokendra Singh Thakur
name: Prasenjit Mondal
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: In the present work, electrocoagulation process has been used to treat arsenic and fluoride containing synthetic water using aluminium electrode. Box–Behnken design, a subnet of response surface methodology, was employed to fix the experimental conditions and Design Expert software was used to evaluate the interaction and effects of different process parameters such as initial pH, current density and run time on removal of arsenic and fluoride as well as the operating cost. Initial concentration of arsenic and fluoride was fixed at 550 μg/l and 12 mg/l, respectively, for all the experiments. High R2 values of three responses (arsenic removal: 0.998, fluoride removal: 0.984 and operating cost: 0.996) ensures a satisfactory adjustment of developed quadratic model with the experimental data. Under the optimum conditions, initial pH: 7, current density: 10 A/m2 and run time: 95 min, the predicted arsenic and fluoride removal is found to be 98.64 and 84.80%, respectively, whereas the operating cost is found to be 0.354 USD/m3. Further, the experimental values of arsenic removal (98.51%), fluoride removal (88.33%) and operating cost (0.343 USD/m3) are found to be in good agreement with the predicted values. The present electrocoagulation process is able to reduce the arsenic and fluoride concentration below 10 μg/l and 1.5 mg/l, respectively, which are maximum contaminant level of these elements in drinking water according to WHO. EDX analysis of sludge confirms the occurrence of arsenic and fluoride in produced sludge and FTIR spectra suggest that arsenic is also removed in the form of As(III). Real groundwater sample collected from Kaudikasa Village, Rajnandgaon District, Chhattisgarh, India and having As: 512 μg/l, F: 6.3 mg/l was also treated under optimum conditions of the present study and the concentration of arsenic and fluoride became below WHO drinking water norms.
Adsorption and removal of diethyl phthalate from aqueous media with poly(hydroxyethyl methacrylate) nanobeads
Creators: name: Özer, Elif Tümay
name: Aslı Göçenoğlu Sarıkaya
name: Osman, Bilgen
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: In this study, poly (hydroxyethyl methacrylate) (PHEMA) nanobeads with an average size of 115 nm were prepared by emulsion polymerization. The nanobeads were characterized with infrared spectroscopy, scanning electron microscopy, and zeta size analysis. The surface area of the PHEMA nanobeads was calculated as 541.4 m2/g. Then, diethyl phthalate (DEP) removal efficiency of the PHEMA nanobeads from aqueous media was investigated. At a fixed adsorbent/solution ratio, various factors affecting the adsorption of DEP from aqueous solution such as pH, initial concentration, contact time, temperature, and adsorbent dosage were analyzed. The maximum DEP adsorption capacity of the PHEMA nanobeads was determined as 265.1 mg/g at pH 4.0, 25°C. The Sips isotherm model fits the experimental data in the wide range of DEP concentration tested (1–300 mg/L). The pseudo-first-order, pseudo-second-order, modified Ritchie’s-second-order kinetic models were used to test the adsorption kinetics. The DEP adsorption capacity of the nanobeads did not change after five batch successive usages. DEP removal efficiency of the PHEMA nanobeads from different water media such as saliva, sweat, and tap water was also evaluated. The removal efficiencies in the range from 82.4 to 100.0% demonstrate the usability of PHEMA nanobeads for DEP removal from real samples.
ENVISION Deliverable 5.1.: Governance Arrangement Inventory
Creators: name: López-Rodríguez, M.D.
name: Oteros-Rozas, E.
name: March, H.
name: Ruíz-Mallén, I.
Publisher: name: Zenodo
Year: 2019
Subjects: Governance arrangements; Environmental governance; Formal procedures; Inclusive conservation; Informal routines; Participatory governance; Protected Areas; National Parks; Spain

description: This deliverable corresponds to ENVISION task 5.1, aiming to identify the governance arrangements behind protected areas (PAs) management, as well as the strengths and gaps in coordination across involved institutions, through a case study in a European PA: The Sierra de Guadarrama National Park (Spain).
Resumen Ejecutivo. Mujeres embarazadas y vacunas contra amenazas epidémicas emergentes: Orientación ética para la preparación, investigación y respuesta
Creators: name: Grupo de Trabajo del Proyecto de ética en la investigación para vacunas, epidemias y nuevas tecnologías (PREVENT)
Publisher: name: Zenodo
Year: 2018
Subjects: Ética de la investigación
Inclusion
Mujeres embarazadas
Covid19
Covid-19
Personas embarazadas

description: Esta Orientación presenta una hoja de ruta para la inclusión éticamente responsable, socialmente equitativa y respetuosa de los intereses de las mujeres embarazadas en el desarrollo y distribución de las vacunas en programas de inmunización contra los patógenos emergentes durante las respuestas a epidemias. La Orientación es un producto del Grupo de Trabajo del Proyecto de ética en la investigación para vacunas, epidemias y nuevas tecnologías (PREVENT) – un equipo internacional multidisciplinario constituido por 17 expertos especialistas en bioética, inmunización materna, medicina maternofetal, obstetricia, pediatría, filosofía, salud pública y políticas e investigación en vacunas, con asesoría de una amplia variedad de partes interesadas y expertos externos. La Orientación empieza proponiendo una visión ambiciosa y se pronuncia a favor de su importancia moral. A continuación, especificamos 22 recomendaciones concretas, organizadas alrededor de tres áreas claves: preparación en salud pública, investigación y desarrollo y la distribución de las vacunas en programas de inmunización durante la respuesta a epidemias. Las recomendaciones están dirigidas a una serie de actores, entre ellos, los formadores de políticas globales y nacionales, las autoridades reguladoras regionales y nacionales, los financiadores y patrocinadores, los fabricantes de vacunas, las instituciones de investigación, las redes de ensayos clínicos y los grupos de investigación, los investigadores individuales, los entes supervisores, los comités de ética en la investigación, las juntas asesoras comunitarias y las organizaciones de la sociedad civil.
description: Cita Krubiner, C. B., Faden, R. R., Karron, R. A., Little, M. O., Lyerly, A. D., Abramson, J. S., Beigi, R. H., Cravioto, A. R., Durbin, A. P., Gellin, B. G., Gupta, S. B., Kaslow, D. C., Kochhar, S., Luna, F., Saenz, C., Sheffield, J. S., & Tindana, P. O. (2018). Resumen Ejecutivo. Mujeres embarazadas y vacunas contra amenazas epidémicas emergentes: Orientación ética para la preparación, investigación y respuesta. Vaccine. Página Web http://vax.pregnancyethics.org/prevent-guidance/ Resumen ejecutivo http://vax.pregnancyethics.org/s/PREVENT-Espanol-ES.pdf Versión completa http://vax.pregnancyethics.org/s/PREVENT-Espanol.pdf
ReVILE: Vial Imaging and Label Extraction example image set
Creators: name: Butcher, Alice Jenny
name: Humphries, Josh
name: Dupont, Steen
name: Price, Benjamin
Publisher: name: Zenodo
Year: 2020
Subjects: collections vials
labels
digitisation

description: Raw video files and rollout photography outputs from ReVILE (Revolving Vial Imaging and Label Extraction). Each item has three files: the input video showing >1 complete rotation, the rollout image of the whole video, and the cropped rollout image showing only one rotation.
The effects of food components on the digestion of DNA by pepsin
Creators: name: Yanfang Zhang
name: Xingyu Wang
name: Xiaoming Pan
name: Liu, Yu
name: Hanqing Wang
name: Dong, Ping
name: Xingguo Liang
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Recently, our study found that naked nucleic acids (NAs) can be digested by pepsin. To better understand the fate of dietary DNA in the digestive tract, in this study we investigated the effects of several food compositions on its digestion. The results showed that protein inhibited the digestion of DNA when the protein:DNA ratio was higher than 80:1 (m/m). DNA found in nucleoprotein (NA), which more closely resembles the state of DNA in food, was as efficiently digested as naked DNA. When the carbohydrate:DNA ratio was 50:1–140:1 (m/m), mono-, di- and polysaccharides did not inhibit DNA digestion. NaCl exhibited an inhibitory effect at 300 mM, whereas divalent cations (Ca2+ and Mg2+) exerted a much stronger inhibitory effect even at 50 mM. The polycation compounds (e.g. chitosan and spermine) showed a significant inhibitory effect at N/P (NH3+/PO4−) = 10:1. The close relationship between food composition and DNA digestion suggests that dietary habits and food complexes are important for understanding the in vivo fate of the ingested DNA in the digestive tract.
title: Jobs, News and Re-offending after Incarceration (LIEPP Working Paper, n°41)
Creators: name: Galbiati, Roberto
name: Ouss, Aurelie
name: Arnaud, Philippe
Publisher: name: Sciences Po - LIEPP
Year: 2015
Subjects: subject: FOS: Social sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Gender quotas have proliferated worldwide as a major tool of gender equality policies, first in the electoral arena and then expanding to other socioeconomic spheres, notably corporate boards. The ensuing rich body of scientific literature on gender quotas so far remains split across disciplines, with a main partition between political science and economics. This scoping review aims at fostering an interdisciplinary dialogue between research on gender quotas conducted from different disciplinary and methodological perspectives. To this effect, we compiled an original bibliographical database of 379 peer-reviewed articles, which we coded according to a series of variables including discipline, geographical area, quota domain, methodology and research question. Drawing on this database, this review presents an overview of the main findings regarding the genesis and the impact of this policy tool, and offers ideas for the further development of interdisciplinary quota research.
title: Visual modeling approach to assess fishing gear efficiency and visual capacity of snow crab (Chionoecetes opilio): a case study on luminescent-netting pots in commercial fisheries
Creators: name: Frank, Colin
Publisher: name: Memorial University of Newfoundland
publisherIdentifier: https://ror.org/04haebc03
publisherIdentifierScheme: ROR
Year: 2024

description: This thesis explored the visual capabilities of snow crab (Chionoecetes opilio) and their interactions with luminescent-netting pots to better understand the role of light intensity during capture. I compared three experimental luminescent-netting pots with increasing brightness to the traditional non-luminescent pots used in the Newfoundland and Labrador snow crab fishery. First, I developed a visual model for snow crab by characterizing their visual parameters, the emitted pot light, and environmental factors. I found that the distance that snow crab can see the light from the pots at 200 meter depth (fishing grounds) depends primarily on the solar angle (height of the sun) and the time elapsed after deployment. I then performed field trials, comparing the catch per unit effort (CPUE; number of crab per pot) and size-selectivity (size-based capture) between each pot treatment. Results showed that the lowest light level pot performed better in comparison to other treatments when considering a balance between commercial, management, and environmental concerns, catching more large crab and fewer small crab. In conclusion, this thesis describes how snow crab vision and pot light intensity effect luminescent-netting pot effectiveness and that increasing the light in luminescent-netting pots does not lead to an improved approach.
Pew Research Center: American Trends Panel Wave 13
Creators: name: Pew Research Center
Publisher: name: Roper Center for Public Opinion Research
Year: 2020

description: Interest in 2016 presidential election (2); choice for Democratic nomination (1); choice for Republican nomination (1); various activities respondent has done in past year (6); frequency of use of various transportation methods (5); own/lease car/truck/motorcycle (1); use of transportation-sharing services (2); sharing economy (1); "gig" economy (1); crowdfunding (1); shopping habits (4); online shopping habits (3); prefer to shop online/from physical store (2); importance of various activities when shopping for new product (7); helpfulness of customer reviews/ratings (3); government oversight/regulation of products/services (3); providing own online reviews/ratings (3); sharing opinions about company/product on social media (3); reading customer ratings/reviews online when buying something for first time (2); pay more attention to extremely negative vs. extremely positive reviews (1); importance of pay/working conditions of workers when deciding where to shop (2); how easy it is to find information on pay and working conditions of workers (1); paying with cash (2); use of cell phone while shopping in physical store (4); Bitcoin (2); use of share economy services (6); earning money online (2); attitude about various "gig" economy jobs (6); use of ride-hailing services (3); ever worked for ride-hailing service (1); ride-hailing services available in respondent's area (1); descriptions of ride-hailing services (12); experiences with ride-hailing services (6); view of Uber/Lyft drivers (1); Uber/Lyft regulation debate (2); responsibility for quality control of ride-hailing services; fundraising websites (21); use of home-sharing services (4); descriptions of home-sharing services (7); experiences with home-sharing services (6); view of home-sharing services (1); legality debate around home-sharing services (2); responsibility for quality control of home-sharing services (3).
Water-soluble polymeric chemosensor for detection of Cu2+ ions with high selectivity and sensitivity
Creators: name: Chiranjit Maiti
name: Banerjee, Rakesh
name: Saikat Maiti
name: Dibakar Dhara
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Plant Biology
subject: Computational Biology

description: Development of water-soluble chemosensors that are selective and sensitive to Cu2+ ions is of tremendous importance owing to their potential applications in biological systems. In the present work, we report the synthesis of a new water-soluble polymer containing pendant rhodamine units that are capable of highly selective and sensitive detection of Cu2+ ions in aqueous medium. Poly(2-pyrrolidinemethyl acrylate) was prepared using RAFT polymerization technique. The pyrrolidine nitrogen group in the polymer was subjected to Aza-Michael type addition with ethyl acrylate that was followed by covalent linking of rhodamine units to the polymer. This polymer was completely water-soluble and found to be capable of sensing Cu2+ ions in aqueous medium. Cu2+-induced opening of the spirolactam ring of the rhodamine units resulted in rapid and easily noticeable colour change, thus enabling a highly selective detection of Cu2+ in μmol range. The ability of these polymeric systems to detect Cu2+ ions in complete aqueous media has more importance than use of organic solvents to solubilize the polymer as reported previously, and thus opened a new window for application of these systems in the detection of copper ions in biological systems.
title: Les stratégies statutaires des établissements d’enseignement supérieur. Une étude des 'journées portes ouvertes' (Working Paper, n°40)
Creators: name: Van Zanten, Agnes
name: Olivier, Alice
Publisher: name: Sciences Po - LIEPP
Year: 2015
Subjects: subject: FOS: Social sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Les « journées portes ouvertes » (JPO) des institutions d’enseignement supérieur (IES) sont présentées par leurs organisateurs et par les divers prescripteurs intervenant auprès des futurs étudiants comme des occasions pour ces derniers de découvrir les offres de formation de différentes IES, de s'informer sur l'organisation des études, leur coût ou leurs débouchés professionnels ainsi que de demander des conseils concernant les procédures d'admission ou les attentes du corps professoral. Ces journées sont néanmoins aussi le lieu où prend place un processus social d'« appariement statutaire » (status matching) (Podolny, 1993) des établissements et des futurs usagers. Pour étudier ce processus, nous analysons des observations des JPO de 9 IES situées dans l’espace francilien, conduites dans le cadre du projet « L’orientation vers l’enseignement supérieur : le rôle des réseaux, des institutions et des marchés » dirigée par A. van Zanten. Pour opérer des distinctions entre les institutions, nous avons consulté leur position dans des classements récents, quand il en existe, mais aussi tenu compte de leurs liens avec différents types d’usagers et avec certaines organisations, notamment les lycées de provenance des élèves et diverses institutions partenaires. Nous distinguons trois types d’IES —à statut élevé, intermédiaire et bas— et comparons leurs messages institutionnels et les moyens par lesquels ces derniers sont transmis aux visiteurs, le but étant de mettre en évidence des différences significatives concernant les stratégies de présentation des établissements. L’analyse des JPO montre que ce dispositif est utilisé par tous les établissements pour mettre en valeur leurs atouts distinctifs par rapport à d’autres IES et pour attirer, et si possible capter, des futurs étudiants pouvant contribuer à reproduire ou à rehausser leur statut. On y observe cependant des différences notables dans la façon dont chaque IES agence les dimensions instrumentales et expressives, la dimension axiologique se trouvant plus en retrait, et dont elle a recours tantôt à une rhétorique de la conviction, tantôt à une rhétorique ou à des supports encourageant la persuasion.
Correlation between vacancy formation and Σ3 grain boundary structures in nickel from atomistic simulations
Creators: name: Abdelmalek Hallil
name: Metsue, Arnaud
name: Jamâa Bouhattate
name: Feaugas, Xavier
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: Hematology

description: Atomistic simulations based on energy minimisation method were employed to compute the structural and defect properties of the symmetric and asymmetric Ni tilt grain boundaries (GBs). The GB structures have been investigated in terms of global GB metrics (GB energy, excess volume) and at the atomic-scale analysis (atomic site energy, binding energy and displacement field of vacancies). The GB properties are treated by the notion of the plane inclination angle between the two symmetric tilt grain boundaries: coherent twin boundary and symmetric incoherent twin boundary configurations. We observed correlations: (i) between the GB energy and the net expansion at the boundary and (ii) between the vacancy properties and GB energetics. We identified that the GB sink efficiency character, which reflects the defect absorption capacity, can be influenced by the GB energy. The minimum defect formation energy in each GB tends to decrease with increasing grain boundary energy. In addition, energetic and structural analyses are linked together to characterise vacancies segregation as a function of the defect location within the GB interface. Our results show a non-symmetric trend especially near the GB plane between the vacancy binding energy and the displacement field generated around the vacancy core. However, the distribution between the binding energy and the displacement field of a vacancy permits to identify whether the atomic relaxations around the GB-defect site are isotropic or anisotropic.
Virtual screening of small molecules databases for discovery of novel PARP-1 inhibitors: combination of in silico and in vitro studies
Creators: name: Salmas, Ramin Ekhteiari
name: Unlu, Ayhan
name: Bektaş, Muhammet
name: Yurtsever, Mine
name: Mestanoglu, Mert
name: Durdagi, Serdar
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Poly(ADP-ribose) polymerase-1 (PARP-1) enzyme has critical roles in DNA replication repair and recombination. Thus, PARP-1 inhibitors play an important role in the cancer therapy. In the current study, we have performed combination of in silico and in vitro studies in order to discover novel inhibitors against PARP-1 target. Structure-based virtual screening was carried out for an available small molecules database. A total of 257,951 ligands from Otava database were screened at the binding pocket of PARP-1 using high-throughput virtual screening techniques. Filtered structures based on predicted binding energy results were then used in more sophisticated molecular docking simulations (i.e. Glide/standard precision, Glide/XP, induced fit docking – IFD, and quantum mechanics polarized ligand docking – QPLD). Potential high binding affinity compounds that are predicted by molecular simulations were then tested by in vitro methods. Computationally proposed compounds as PARP-1 inhibitors (Otava Compound Codes: 7111620047 and 7119980926) were confirmed by in vitro studies. In vitro results showed that compounds 7111620047 and 7119980926 have IC50 values of 0.56 and 63 μM against PARP-1 target, respectively. The molecular mechanism analysis, free energy perturbation calculations using long multiple molecular dynamics simulations for the discovered compounds which showed high binding affinity against PARP-1 enzyme, as well as structure-based pharmacophore development (E-pharmacophore) studies were also studied.
Entretien de Waed Hamd al-Badur auprès de Yahya al-Rawashdeh à propos du village d'al-Muqar'iyeh (région de Ma'an)
Creators: name: al-Rawashdeh, Yahya
name: Waed Hamd Al-Badur (Enquêtrice)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Source: http://www.calames.abes.fr/pub/ms/FileId-3139
description: Coverage: Al-Muqar'iyeh (Ma'an, Jordanie)
title: Catalogus Realis. II. Sprachwissenschaft : A 1 - 30 ; B 1 - 79 ; C 1 - 206.
Creators: name: Philipps-Universität Marburg
Publisher: name: Philipps-Universität Marburg
Year: 2020
Subjects: Systematischer Katalog
Hassiaca
Library and information sciences
Bibliotheks- und Informationswissenschaft

description: Elektronische Reproduktion von: Catalogus Realis. II. Sprachwissenschaft : A 1 - 30 ; B 1 - 79 ; C 1 - 206. . - Stand: Dezember 2019. - Standort: Universität Marburg, Universitätsbibliothek. - Signatur: Sonderlesesaal. - Bemerkungen: Standortkatalog I. (gebundener systematischer Katalog). Für Erwerbungsjahre bis 1957 (römische Signaturen). Der Standortkatalog I ist ein Arbeitsinstrument, in dem auch nach seiner Digitalisierung in 2019 weiterhin Änderungsvermerke gemacht werden. - Anordnung: römische Signaturen von I - XX. - Innerhalb sehr unterschiedlich, Bestand teilweise nach Formaten getrennt, teilweise aber auch in einer Abfolge (Formatangabe in Spalten links). Wenn kein Platz mehr in der Nummernfolge war, wurde teilweise auf die gegenüberliegende Seite ausgewichen oder auf neu eingelegte Blätter, dadurch kann sich die Signatursuche auf mehrere Seiten erstrecken. - Inhalt: alle Einzelsignaturen und alle gemeinsamen Grundsignaturen.Teilweise wird heute noch der Bestand nachgetragen, aber in vielen Fällen auch Stempel "Forts. s. Standortkatalog 3". - Digitalisiert 2020
Virtual Screening of Small Molecules Databases for Discovery of Novel PARP-1 Inhibitors: Combination of in silico and in vitro Studies
Creators: name: Salmas, Ramin Ekhteiari
name: Unlu, Ayhan
name: Bektaş, Muhammet
name: Yurtsever, Mine
name: Mestanoglu, Mert
name: Durdagi, Serdar
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Poly(ADP-ribose) polymerase-1 (PARP-1) enzyme has critical roles in DNA replication repair and recombination. Thus, PARP-1 inhibitors play an important role in the cancer therapy. In the current study we have performed combination of in silico and in vitro studies in order to discover novel inhibitors against PARP-1 target. Structure-based virtual screening was carried out for an available small molecules database. 257951 ligands from Otava database were screened at the binding pocket of PARP-1 using high throughput virtual screening (HTVS) techniques. Filtered structures based on predicted binding energy results were then used in more sophisticated molecular docking simulations (i.e., Glide/SP, Glide/XP, Induced Fit Docking- IFD, and Quantum Mechanics Polarized Ligand Docking- QPLD). Potential high binding affinity compounds that are predicted by molecular simulations were then tested by in vitro methods. Computationally proposed compounds as PARP-1 inhibitors (Otava Compound Codes: 7111620047 and 7119980926) were confirmed by in vitro studies. In vitro results showed that compounds 7111620047 and 7119980926 have IC50 values of 0.56 μM and 63 μM against PARP-1 target, respectively. The molecular mechanism analysis, Free Energy Perturbation calculations using long multiple molecular dynamics (MD) simulations for the discovered compounds which showed high binding affinity against PARP-1 enzyme, as well as structure-based pharmacophore development (E-pharmacophore) studies were also studied.
A reversible colourimetric and selective fluorescent chemosensor for the cascade recognition of Cu2+ and H2PO4− in aqueous solution
Creators: name: Taibao Wei
name: Li, Hui
name: Qingqing Wang
name: Taotao Lu
name: Yuanrong Zhu
name: Lin, Qi
name: Youming Zhang
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Plant Biology

description: This report describes a reversible colourimetric and on–off–on module of fluorescent chemosensor for selective cascade recognition of Cu2+ and with unique output optical response in aqueous solution. On the other hand, F−, Cl−, Br−, I−, CH3COO−, HSO4−, ClO4−, CN− and SCN− did not induce significant changes in fluorescence. Moreover, the colour change in chemosensor LH by response of this colourimetric chemosensor can be visualised by naked eye. These fluctuations in spectral response, under electronic behaviour, can be viewed to mimic as IMPLICATION logic gate. The proposed structures of LH for Cu2+ and LH –Cu2+ for anions.