Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction
Creators: name: Wan, Elizabeth R.
name: Siew, Keith
name: Saravia-Butler, Amanda M.
name: Afsari, Fatemeh
name: Patel, Vaksha
name: Oliveira, Lorraine Christine De
name: Blaber, Elizabeth
name: Nestler, Kevin A.
name: D’Ambrosio, Viola
name: Klosinska, Aleksandra S.
name: Nelson, Charlotte
name: Al-Jaber, Maneera Yousef
name: Figg, Nichola
name: Burling, Keith
name: Sosa, Julio
name: Zwart, Sara R.
name: Sanchez-Hodge, Rebekah
name: Paul, Anindya S.
name: Naglah, Ahmed
name: Nicod, Jérôme
name: Finch, Rebecca
name: Foox, Jonathan
name: Kim, JangKeun
name: Uruno, Akira
name: Shiba, Dai
name: Barker, Peter
name: Rodríguez-Lopez, María
name: Galazka, Jonathan M.
name: Roufosse, Candice
name: Yun, Sanghee
name: Costes, Sylvain V.
name: Cubitt, Laura
name: Campbell, Robert A. A.
name: Matei, Irina
name: McCann, Colleen M.
name: Faridi, Pouya
name: Broni-Tabi, Jessica
name: Tanuwidjaya, Erwin
name: Walker-Samuel, Simon
name: Eisch, Amelia J.
name: Yamamoto, Masayuki
name: Steele, Joel Ricky
name: Karouia, Fathi
name: Altinok, Selin
name: Yang, Xiaoping
name: Beheshti, Afshin
name: Slawinski, Hubert
name: Walsh, Stephen B.
name: Gordon, Peter
name: Tabetah, Marshall
name: Scott, Ryan T.
name: Li, Yinghui
name: Oswalt, Leah
name: Patras, Laura Ioana
name: Zhang, Haijian
name: Bah, Nourdine
name: Border, Samuel
name: Li, Zhongwang
name: Lee, Han-Chung
name: Arif, Shehbeel
name: Grillo, Alessandra
name: Snell, Daniel
name: Houerbi, Nadia
name: O’Shaughnessy, Kevin M.
name: Boyko, Valery
name: Cheng-Campbell, Margareth
name: Smith, Scott M.
name: Kiffer, Frederico C.
name: Colón, Lorianna M.
name: Degoricija, Lovorka
name: Kubik, Angela
name: Vaughan, Michael B.
name: Sadeghi-Alavijeh, Omid
name: Muratani, Masafumi
name: Baranzini, Sergio
name: Fazelinia, Hossein
name: Zhong, Chutong
name: Mason, Christopher E.
name: Choy Lim Kam Sian, Terry Chin
name: Cheshire, Chris
name: Lucarelli, Nicholas
name: Marullo, Anthony L.
name: da Silveira, Willian A.
name: Mimar, Sayat
name: Godovac-Zimmermann, Jasminka
name: Sarder, Pinaki
name: French, Alison
name: Gebre, Samrawit
name: Dai, Zhongquan
name: Valipour Kahrood, Hossein
name: A.C.Almeida, Eduardo
name: Sanders, Lauren M.
name: Meydan, Cem
name: Allen, Noah
name: Overbey, Eliah
name: Schittenhelm, Ralf Bernd
name: Schweickart, Annalise
name: Mohamed-Alis, Vidya
name: Yasmin, 
name: Schisler, Jonathan C.
name: Lai Polo, San-huei
name: Rodriques, Samuel
name: Lynham, Steven
name: Brown, Amanda L.
name: Al-Maadheed, Mohammed
Publisher: name: Springer Nature
Year: 2024

description: Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored. We performed biomolecular (epigenomic, transcriptomic, proteomic, epiproteomic, metabolomic, metagenomic), clinical chemistry (electrolytes, endocrinology, biochemistry) and morphometry (histology, 3D imaging, miRNA-ISH, tissue weights) analyses using samples and datasets available from 11 spaceflight-exposed mouse and 5 human, 1 simulated microgravity rat and 4 simulated GCR-exposed mouse missions. We found that spaceflight induces: 1) renal transporter dephosphorylation which may indicate astronauts’ increased risk of nephrolithiasis is in part a primary renal phenomenon rather than solely a secondary consequence of bone loss; 2) remodelling of the nephron that results in expansion of distal convoluted tubule size but loss of overall tubule density; 3) renal damage and dysfunction when exposed to a Mars roundtrip dose-equivalent of simulated GCR.