cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
La science ouverte et moi : enjeux et perspectives
Creators: name: Marie, Garambois
name: Federico, Nurra
Publisher: name: Zenodo
Year: 2023
Subjects: Open science
Open Access
Open Data
Art History

description: Présentation donnée dans le cadre du cycle de formation "Diffuser son travail de recherche" à l'Institut national d'histoire de l'art.
title: Право социального обеспечения
Creators: name: ELS IPR BOOKS
Publisher: name: Средне-Волжский институт (филиал) ВГУЮ (РПА Минюста России)
Year: 2019

description: Учебное пособие «Право социального обеспечения» подготовлено в соответствии с программой курса на основе действующего законодательства Российской Федерации в сфере социального обеспечения. Учебное пособие ставит целью изучение главных тем курса, включает в себя вопросы пенсионного обеспечения, социального обслуживания, государственной социальной помощи, охраны здоровья граждан, что будет способствовать динамичному процессу усвоения учебного материала и грамотной ориентации в правовом поле. Учебное пособие может быть использовано в работе студентов, аспирантов, научных сотрудников, практических работников, а также всеми интересующимися вопросами социального обеспечения.
Occurrence of microplastics in water, feed, and tissues of European seabass produced in recirculating aquaculture system
Creators: name: Matias, R. S.
name: Gomes, S.
name: Barboza, L. G. A.
name: Guilhermino, L.
name: Valente, M. P.
Publisher: name: Scientific Letters
Year: 2023

description: Background: Microplastics (MPs) in seafood are a global major concern to human health [1]. Due to MPs’ ubiquitous presence in aquatic ecosystems, aquacultures are also susceptible to contamination from external or endogenous sources. Previous studies have reported MP occurrence in farmed organisms [2], but little is known about recirculating aquaculture systems (RAS), which provide an opportunity for sustainable seafood production under environmentally controlled conditions. Objective: The present study aimed to investigate MP occurrence in several body sites of European seabass (Dicentrarchus labrax) produced in a RAS, due to the high presence of plastic components. MP occurrence in two direct exposure routes, water and feed, was also evaluated. Methods: Water, feed, and 55 fish were collected from a RAS facility. MP retention in seabass was investigated in the gastrointestinal tract (GIT), gills, liver, and dorsal muscle [3]. Bioconcentration (BCF) and bioaccumulation (BAF) factors of MPs were estimated [4]. Results: MP concentrations in water and feed were 37.2±1.9 MP/L and 3.9±1.3 MP/g, respectively. In total, 422 MPs were recovered from seabass body sites: GIT presented the highest concentration (1.0±0.8 MP/g) and muscle the lowest (0.4±0.3 MP/g). All fish had MPs recovered from at least two of the analysed body sites. Black, blue, and transparent fibres made of regenerated cellulose and polyethylene terephthalate were the most common particles. Polymers linked to RAS components (e.g., polyethylene, polypropylene) occurred in low quantity, suggesting a limited system’s contribution to overall MP levels. BCF and BAF values equal to 19.9 and 0.2, respectively, indicating MP bioconcentration in fish (i.e., >1), but no bioaccumulation. Conclusions: RAS-farmed seabass are susceptible to MPs through water and feed, potentially retaining MPs in tissues. MP occurrence in muscle highlights RAS-farmed fish as a potential dietary exposure pathway to humans, but further dedicated risk evaluation studies are required to fully ascertain the relevance of such finding for consumers.
description: Scientific Letters, Vol. 1 No. Sup 1 (2023)
Bioinsecticide SPINTOR®: detrimental effects on earthworms Eisenia fetida at different levels of biological organization
Creators: name: Moreira, A.
name: Nogueira, V.
name: Bouguerra, S.
name: Rodrigues, S.
Publisher: name: Scientific Letters
Year: 2023

description: Background: The increasing interest in sustainable agricultural practices led to the use of biopesticides instead of synthetic ones [1]. SPINTOR® (SPI) is a commercialized bioinsecticide that employs spinosad as its active ingredient, a natural by-product obtained from the Saccharopolyspora spinosa fermentation [2]. Although effective in controlling several pests, SPI also can present inadvertent effects on non-target organisms in different environmental compartments [3]. Eisenia fetida is an example of soil fauna that can be affected and is frequently used as model organisms in soil ecotoxicology research. Objective: The objective of this study is to evaluate the potential ecotoxicity of SPINTOR® on several endpoints of E. fetida. Methods: The effect of SPI on the reproduction [4] and avoidance behavior [5] of E. fetida was assessed following standard protocols. A short-term exposure of 48 h was also carried out. The experimental design consisted in eight treatments of a natural soil spiked with different concentrations of SPI (0.00 up to 1.49 mg of active ingredient/kg of soildw). The concentrations were determined based on the application dose and environmental relevance. The E. fetida adults from the short-term exposure (48 h) and the reproduction assay (28 d) were further processed to assess several biochemical parameters, including biomarkers related to oxidative stress, energy reserves, neurotransmission, and genotoxic effects through the comet assay. Results: Initial findings indicate that chronic exposure of E. fetida causesalterations to its energy-related metabolic pathways and antioxidant defenses. And although no effects were observed in the number of juveniles produced at the end of the assay, E. fetida show a tendency to avoid the contaminated soil in the highest concentrations, as well as significant DNA damage was observed after 48 h of exposure. Conclusions: It can be inferred that SPINTOR® has a negative impact on the health and wellness of E. fetida, potentially impairing their crucial roles in terrestrial ecosystems.
description: Scientific Letters, Vol. 1 No. Sup 1 (2023)
Sphinx measurements of the 2009 solar minimum x-ray emission
Creators: name: Sylwester, J.
name: Kowalinski, M.
name: Gburek, S.
name: Siarkowski, M.
name: Kuzin, S.
name: Farnik, F.
name: Reale, F.
name: Phillips, K. J. H.
name: Bakala, J.
name: Gryciuk, M.
name: Podgorski, P.
name: Sylwester, B.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The SphinX X-ray spectrophotometer on the CORONAS-PHOTON spacecraft measured soft X-ray emission in the 1-15 keV energy range during the deep solar minimum of 2009 with a sensitivity much greater than GOES. Several intervals are identified when the X-ray flux was exceptionally low, and the flux and solar X-ray luminosity are estimated. Spectral fits to the emission at these times give temperatures of 1.7-1.9 MK and emission measures between 4 x 10^47 cm^-3 and 1.1 x 10^48 cm^-3. Comparing SphinX emission with that from the Hinode X-ray Telescope, we deduce that most of the emission is from general coronal structures rather than confined features like bright points. For one of 27 intervals of exceptionally low activity identified in the SphinX data, the Sun's X-ray luminosity in an energy range roughly extrapolated to that of ROSAT (0.1-2.4 keV) was less than most nearby K and M dwarfs.
description: Astrophysical Journal, in press. 14 pp, 3 figures
But it works on my machine?! ONNX 101
Creators: name: Aleksandar, Ivanovski
Publisher: name: Zenodo
Year: 2023
Subjects: Machine Learning
Interoperability
ONNX
Linux Foundation

description: In the dynamic world of machine learning, interoperability across frameworks and platforms is paramount. Enter Open Neural Network Exchange (ONNX), a game-changing initiative that empowers data scientists and developers to seamlessly move models between various deep learning frameworks. In this concise 10-minute talk, we'll embark on a journey into the fundamentals of ONNX, shedding light on its key concepts, benefits, and practical applications.
Systematic Construction of Natural Deduction Systems for Many-valued Logics: Extended Report
Creators: name: Baaz, Matthias
name: Fermüller, Christian G.
name: Zach, Richard
Publisher: name: IEEE
Year: 1993
Subjects: natural deduction
sequent calculus
normal form
cut-free derivation
many-valued logic

description: Unpublished longer version of a paper in: Proc. 23rd International Symposium on Multiple Val- ued Logic, Sacramento, CA, May 24–28, 1993, IEEE Press
description: We exhibit a construction principle for natural deduction systems for arbitrary finitely-many-valued first order logics. These systems are systematically obtained from sequent calculi, which in turn can be extracted from the truth tables of the logics under consideration. Soundness and cut-free completeness of these sequent calculi translate into soundness, completeness and normal form theorems for the natural deduction systems.
Seabirds as bioindicators of anthropogenic and chemical pollution
Creators: name: Matos, D. M.
name: Ramos, J. A.
name: Brandão, L. C.
name: Bessa, F.
name: Silva, V.
name: Rodrigues, I.
name: Antunes, S.
name: Dos Santos, I.
name: Coentro, J.
name: Cunha, S. C.
name: Fernandes, J. O.
name: Batista De Carvalho, L. A. E.
name: Marques, M. P. M.
name: Santos, S.
name: Paiva, V. H.
Publisher: name: Scientific Letters
Year: 2023

description: Background: Marine pollution, caused by anthropogenic debris, is a significant environmental issue that has detrimental effects on marine ecosystems ​[1]​. Finding suitable sentinel species of the human impacts on the oceans, is imperative. As top predators, seabirds are considered sentinels of the marine environment ​[2]​. Objective: To provide quantitative data about the distinctive prevalence of anthropogenic pollution on seabirds, five species with different trophic and foraging ecology inhabiting the tropical Atlantic region were used. Methods: The occurrence of anthropogenic debris was assessed using faeces as a proxy for ingestion. Particles were chemically analysed using micro-Fourier transform infrared spectroscopy (mFTIR) ​[3]​. Moreover, preen oil and plasma samples were analysed for Polybrominated Diphenyl ethers (PBDEs) and methoxylated PBDEs (MeO-PBDEs), through with gas chromatography–mass spectrometry (GC-MS/MS) ​[4]​. Results: There were found 438 items suspected of anthropogenic origin, mostly fragments and fibres in all species. Phaethon aethereus (PA n=61), Calonectris edwardsii (CE n=119) and Sula leucogaster (SL n=82) presented the highest frequency occurrence (FO: 51%, 49%, 48%), while Bulweria bulwerii (BB =86) and Puffinus lherminieriboydi (PB n=86) the lowest (FO: 30%, 36%) of anthropogenic particles. Particles revealed a high diversity of polymers, from cellulosic particles to synthetic plastics. PBDEs and MeO-PBDEs were detected in all species and matrices, whereby preen oil had higher concentrations and variety of congeners than plasma. PB had the lowest chemical concentrations in both tissues compared to other species. Moreover, it was not found any correlation between chemical compounds concentration and the number or occurrence of anthropogenic particles. However, particles and chemical compounds were more prevalent in species that explore areas associated to anthropogenic activities. Conclusions: Overall, anthropogenic pollution is transversal to all species, ranging from particle ingestion to chemical compounds. We considered that it is necessary to continue monitoring the impacts of global anthropogenic pollution considering the declines in seabirds’ population.
description: Scientific Letters, Vol. 1 No. Sup 1 (2023)
Hedgehogs (Erinaceus europaeus) as bioindicators of heavy metal(loid) pollution
Creators: name: Jota Baptista, C.
name: Seixas, F.
name: Gonzalo-Orden, J. M.
name: Patinha, C.
name: Pato, P.
name: Ferreira Da Silva, E.
name: Casero, M.
name: Brazio, E.
name: Brandão, R.
name: Costa, D.
name: Mateus, T. L.
name: Oliveira, P. A.
Publisher: name: Scientific Letters
Year: 2023

description: Background: Heavy metal(loid)s pollution is a One Health concern [1]. Hedgehogs (Erinaceus europaeus) are promising candidates for biomonitoring programs, due to their habits, abundance, distribution and resilience [2]. Objective: This work aims to evaluate heavy metal(loid)s pollution, using E. europaeus as a bioindicator. Methods: Necropsies of 46 hedgehogs from three distinct rescue centres (CERVAS, LxCRAS and RIAS) were performed. Provenance and clinical data (when available) were recorded. Sex and age group were estimated. Liver, kidney and external spines (2-10 grams) were collected and stored under -20ºC. Internal organs were completely freeze-dried for two days at -56ºC (LaboGeneCoolSafe®) and stored frozen until further analysis. Spines were washed in an ultrasound machine (Sonorex RK 106®) and dried overnight in an oven (55ºC). Acid digestion was performed in a digestion plate (DigiPrep-MS®) and metal(loid)s concentrations (As, Cd, Cr, Cu, and Pb) were determined with ICP-MS. Liver and kidney were also collected for histopathology routine examination. Results: High levels of Cu were found in the kidney (24.74±21.05 mg kg-1 dry weight [dw]) and liver (35.66 ± 19.65 mg kg-1dw), with some animals passing 100 mg kg-1 dw, which is a high value for insectivores [3]. Significant correlations have been found between spines and liver and between spines and kidney, for Co (p<0.001, in both organs) and Pb (p=0.020 and p=0.019), suggesting spines as a non-invasive sample to access internal metal(loid) concentrations. Biliary hyperplasia was the most frequent lesion observed (36%)- Animals presenting biliary hyperplasia show higher levels of metal(loid)s, with a significant difference for Cd (p=0.007) and Co (p=0.019). Conclusions: Further research, including different locations and organs, is mandatory to comprehend the real impact of metal(loid)s pollution in different Portuguese locations, under a One Health perspective.
description: Scientific Letters, Vol. 1 No. Sup 1 (2023)
title: Учебное уголовное дело
Creators: name: ELS IPR BOOKS
Publisher: name: Средне-Волжский институт (филиал) ВГУЮ (РПА Минюста России)
Year: 2019

description: Предлагаемое учебное пособие включает в себя образцы процессуальных документов, составляемых в ходе производства по уголовному делу в стадиях возбуждения уголовного дела, предварительного расследования, подготовки уголовного дела к судебному заседанию, судебного разбирательства. Учебное пособие рассчитано на использование при проведении занятий по дисциплинам «Уголовно-процессуальное право (Уголовный процесс)», «Следователь (дознаватель) в уголовном судопроизводстве», «Нарушения уголовно-процессуального законодательства и пути их устранения» у студентов очной и заочной форм, обучающихся в СВИ (ф) ВГУЮ (РПА Минюста РФ) в г. Саранске.
Performance study of low environmental impact mortars based on mineral additions and cement resistant to sulfate (CRS)
Creators: name: Belagraa, Larbi
name: Bouzid, Abderrazak
Publisher: name: Wroclaw University of Science and Technology, Faculty of Geoengineering, Mining and Geology
Year: 2016
Subjects: Cement Resistant to Sulphate (CRS), pozzolan, environmental performance mortars, mechanical development, physical-chemical properties

description: Mining Science
Selection of sewer pipe materials : comparing two lifecycle approaches
Creators: name: Akhtar, Sharmin
Publisher: name: University of British Columbia
Year: 2012

description: Sewer systems are subjected to deterioration due to aging, aggressive environmental factors, increased demand, inadequate design, improper operation and maintenance activities. As a result their current-state and overall long-term performance are affected, which often requires costly and extensive maintenance, repair and rehabilitation. Therefore, it becomes a challenging task for the decision-makers to make a decision that improves design, construction, operation and maintenance activities. The main aim of this study is to evaluate different materials of sewer pipes (i.e., concrete, polyvinyl chloride, vitrified clay and ductile iron) and identify sustainable solutions using both an emergy-based lifecycle approach and a traditional lifecycle approach. Emergy method converts all forms of lifecycle inflows (such as energy, raw resources, labour, money, services and information) to an equivalent form of solar energy, named solar emergy joule (sej), which does not require any multi -criteria method to aggregate non-commensurate values. On the other hand, in traditional lifecycle approach, analytical hierarchical process method has been used to integrate environmental and economic impacts of different pipes. Analysis based on emergy-based LCA approach is useful and more credible, as it measures the contribution of environmental and economic impacts in a common unit which removes the multi-criteria dilemma. The analysis results demonstrate that PVC pipe is the most sustainable option from both environmental and economic points of view and can guarantee a more sustainable sewer system.
Fighting occupational risks among Portuguese wildland firefighters: looking at cytogenetic effects
Creators: name: Esteves, F.
name: Slezakova, K.
name: Madureira, J.
name: Vaz, J.
name: Fernandes, A.
name: Carmo, M.
name: Morais, S.
name: Teixeira, J. P.
name: Costa, S.
Publisher: name: Scientific Letters
Year: 2023

description: Background: Evidence linking wildland firefighters’ occupational exposure and health outcomes is still limited. Cytogenetic endpoints have long been applied in the surveillance of human genotoxic exposures and early effects of genotoxic carcinogens. Therefore, it is of utmost importance to clarify the exposure-induced cytogenetic effects concerning wildland firefighters’ occupational exposure at different time points (Pre-fire season and fire season). Objective: Here, we aim to evaluate the cytogenetic levels in buccal cells among a group of wildland firefighters during a Pre-fire season, considering both the i) influence of self-reported variables (e.g., lifestyle) on buccal micronucleus cytome assay (BMCyt) outcomes and ii) the cytogenetic damage in exfoliated buccal cells considering the estimated inhalation doses to particulate matter (PM) in non-fire work settings. Methods: A total of 176 northern Portuguese wildland firefighters (82% males; mean age of 37.5 ± 10.9) were recruited during the pre-fire season of 2021. Relevant information was obtained through a self-administered questionnaire. Genomic instability was assessed for 172 northern Portuguese wildland firefighters by BMCyt. PM10 and PM2.5 inhalation doses (indoor/outdoor) were estimated for a group of 80 firefighters based on methods described elsewhere [1]. Results: Some lifestyle variables (e.g., daily consumption of vegetables) shown to have a protective role on some BMCytendpoints (p<0.05), whereas others such coffee consumption or being part of Permanent Intervention Teams (full-time firefighters) presented a negative impact (p<0.05). No significant association was found between estimated inhaled doses of PM10 and PM2.5 (mean 1.73 ± 0.43 µg kg-1 and 0.53 ± 0.21 µg kg-1, correspondingly) and BMCyt endpoints. Conclusions: The characterization of a population is a very important step to have a broad perspective of the potential risk factors that may influence the studied endpoints in further analysis. Surveillance based on (bio)monitoring programs may be a crucial tool to identify firefighters at high risk for developing adverse health outcomes.
description: Scientific Letters, Vol. 1 No. Sup 1 (2023)
Sustainability of the Portuguese autochthonous hens breeds: characterization of the productive system (eggs)
Creators: name: Meira, M.
name: Afonso, I.
name: Ribeiro, V.
name: Dantas, R.
name: Brito, N. V.
Publisher: name: Scientific Letters
Year: 2023

description: Background: The conservation of animal genetic resources represents an opportunity for the promotion of local genetic resources with benefits for marginal areas that have economic, cultural, social, and environmental potential, scientific use and that contribute to the sustainable preservation of biodiversity [1, 2]. In Portugal, four autochthonous chicken breeds have been recognized as being at risk of extinction, bred under traditional production systems, as dual-purpose animals for meat and eggs [2,3]. Consumer concern regarding the sustainability of production and animal welfare has strongly increased the demand for eggs and meat that are produced through alternative and extensive farming methods [4,5]. Objective: The aim of this study was to characterize the yield performance of indigenous Portuguese hens and evaluate the physicochemical composition of the eggs. Methods: Records were taken from hens bred in AMIBA farm with several flocks, sorted by breed. The production cycle was controlled during 2 years. The protein and mineral contents of the yolk and albumen in 240 eggs, 60 per breed, were estimated; protein content was determined according to Kjeldahl method (ISO 937:1978), while the mineral composition (P, K, Ca, Mg, Na, Fe, and Zn) was determined in freeze-dried samples [6]. Results: The four native Portuguese breeds perform well under extensive systems, with Pedrês Portuguesa appearing to be the most efficient laying breed. Productivity is significantly influenced by the hens’ age and season, in tandem with the rearing system. The physicochemical composition and mineral content differ between breeds and egg constituents, with a higher protein content compared to a commercial genotype. K, Ca, Fe, and Zn contents were superior in native breeds when compared to the commercial genotype. Conclusions: Local breeds offer opportunities to adapt livestock to low-input environments and the characterization of the quality traits shows a strong contribute to future forms of sustainable poultry production.
description: Scientific Letters, Vol. 1 No. Sup 1 (2023)
Observer-Based Robust Model Predictive Control for a Multi-DOF Oilwell Drill String with Stick-Slip Oscillations
Creators: name: Farhangfar, Ali
Publisher: name: Schulich School of Engineering
Year: 2022
Subjects: subject: Observer
subject: Control
subject: Drill string
subject: Engineering

description: In the petroleum industry, drilling plays an important role. One of the critical issues in the drilling process is human-machine interactions since a more automated method is desired to reduce process costs and improve the safety of operations. This research includes two main parts. The first central part analyzes sets of field data to show the effect of a Process Automation Control (PAC) on the drilling process, which in the results section indicates the usefulness of PAC systems. The second central part is designing a control system that suits the drill string dynamic system to increase process automation. The first part is straightforward, and it was published in 2018 (Farhangfar et al. 2018). The second part includes an observer design that can estimate downhole data, which is difficult and expensive to measure. A Robust Model Predictive Control (RMPC) system (in the finite horizon and infinite horizon forms) is presented, which can stabilize drilling performance by scheduling rotational speeds along the drill string. After designing the observer-based control system and proving that it is working on a simple dynamic system, it is applied to the drill string dynamic system. Its results are compared with the installed controller on the field.
«Just as Dante, so too Michelangelo. The Sculptor’s “Doglienza” in Francesco da Sangallo’s Letter,» in: "Lettres d’Artistes. L’anthologie de Benedetto Varchi. Dialogue entre Vasari, Bronzino, Pontormo, Bastiano del Tasso, Francesco da Sangallo, Tribolo, Cellini et Buonarroti," ed. by F.D. de Gaillarbois and O. Chiquet (Paris: Spartacus IDH, 2021), pp. 61-74
Creators: name: Donetti, Dario
Publisher: name: Unknown
Year: 2021

description: The chapter presents an in-depth analysis of the letter by Francesco da Sangallo, published in 1550 as an appendix to Benedetto Varchi's "Lezzione sulla maggioranza della arti" under the light of the artist's interest for Dante Alighieri and his artistic relationship with Michelangelo Buonarroti.
A Test for Radial Mixing Using Local Star Samples
Creators: name: Yu, Jincheng
name: Sellwood, J. A.
name: Pryor, Carlton
name: Chen, Li
name: Hou, Jinliang
Publisher: name: arXiv
Year: 2012
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We use samples of local main-sequence stars to show that the radial gradient of [Fe/H] in the thin disk of the Milky Way decreases with mean effective stellar temperature. Many of these stars are visiting the solar neighborhood from the inner and outer Galaxy. We use the angular momentum of each star about the Galactic center to determine the guiding center radius and to eliminate the effects of epicyclic motion, which would otherwise blur the estimated gradients. We interpret the effective temperature as a proxy for mean age, and conclude that the decreasing gradient is consistent with the predictions of radial mixing due to transient spiral patterns. We find some evidence that the trend of decreasing gradient with increasing mean age breaks to a constant gradient for samples of stars whose main-sequence life-times exceed the likely age of the thin disk.
description: Accepted to appear in ApJ, 8 pages, 8 figures
Cardiac mitochondrial dynamics, autophagy and regeneration are stirred by doxorubicin in old CD-1 mice
Creators: name: Brandão, S. R.
name: Reis-Mendes, A.
name: Neuparth, M. J.
name: Carvalho, F.
name: Ferreira, R.
name: Costa, V. M.
Publisher: name: Scientific Letters
Year: 2023

description: Background: The chemotherapeutic agent doxorubicin (DOX) has been widely used in the treatment of solid tumors and hematological malignancies [1]. However, serious adverse side effects have emerged in patients treated with this drug, notably cardiotoxicity [2]. Moreover, aging is a risk factor for the development of cardiovascular diseases in cancer treated patients [3]. Objective: We herein aimed to evaluate the molecular effects of DOX on the cardiac muscle of old CD-1 mice. Methods: Old CD-1 male mice (19 months) were administered with a pharmacologically relevant cumulative dose of 9 mg/kg DOX (DOX group) or saline (CTRL group), distributed intraperitoneally for three weeks (biweekly). The experiments were performed with the approval of the national competent authorities (DGAV, reference nº 0421/000/000/2016). Animal welfare was monitored daily. Two months after the last drug or saline administration, mice were sacrificed for collection of blood and heart. Results: Serum glucose concentration was decreased after DOX administration, but no other differences were seen in serum markers evaluated. Regarding the heart, DOX increased the activity of citrate synthase (CS), suggesting increased mitochondrial density. Moreover, the content of peroxisome proliferator-activated receptor γ coactivator 1 α (PGC-1α) was decreased after DOX, pointing to decreased mitochondrial biogenesis. In parallel, the content of Beclin1 and microtubule-associated protein light chain 3 (LC3B) was decreased in DOX group, highlighting lower activation of autophagy. In addition, the content of mast/stem cell growth factor receptor Kit (SCFR) was increased after DOX, pointing to activation of cardiac regeneration. Conclusions: This work showed that even a low cumulative dose of DOX affects the cardiac muscle in multiple pathways requiring further studies to find new molecular mechanisms as to clinically address the cardiotoxicity induced by this anticancer agent.
description: Scientific Letters, Vol. 1 No. Sup 1 (2023)
Knot contact homology
Creators: name: Ekholm, Tobias
name: Etnyre, John
name: Ng, Lenhard
name: Sullivan, Michael
Publisher: name: arXiv
Year: 2011
Subjects: subject: Symplectic Geometry (math.SG)
subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 53D42 (Primary) 57R17, 57M27 (Secondary)

description: The conormal lift of a link $K$ in $\R^3$ is a Legendrian submanifold $Λ_K$ in the unit cotangent bundle $U^* \R^3$ of $\R^3$ with contact structure equal to the kernel of the Liouville form. Knot contact homology, a topological link invariant of $K$, is defined as the Legendrian homology of $Λ_K$, the homology of a differential graded algebra generated by Reeb chords whose differential counts holomorphic disks in the symplectization $\R \times U^*\R^3$ with Lagrangian boundary condition $\R \times Λ_K$. We perform an explicit and complete computation of the Legendrian homology of $Λ_K$ for arbitrary links $K$ in terms of a braid presentation of $K$, confirming a conjecture that this invariant agrees with a previously-defined combinatorial version of knot contact homology. The computation uses a double degeneration: the braid degenerates toward a multiple cover of the unknot which in turn degenerates to a point. Under the first degeneration, holomorphic disks converge to gradient flow trees with quantum corrections. The combined degenerations give rise to a new generalization of flow trees called multiscale flow trees. The theory of multiscale flow trees is the key tool in our computation and is already proving to be useful for other computations as well.
description: v2: 120 pages, technical correction to choice of auxiliary angles in section 6.3.1
From Molecular Photochemistry to Supramolecular Photochemistry: A Paradigm for the 1990s
Creators: name: Turro, Nicholas J.
Publisher: name: Columbia University
Year: 1996
Subjects: Chemistry

description: The paradigm of molecules and the covalent bond between atoms has been a powerful and unifying principle for chemistry and photochemistry for decades. We now consider a "paradigm shift" which has been occurring during the past two decades and which may take its place along side the molecular paradigm during the 1990s, namely, the paradigm of supramolecular chemistry.
title: Einführung Hardware/Software PC-Propädeutikum
Creators: name: Nonhoff, Jürgen
Publisher: name: FH Münster
Year: 2003
Subjects: subject: 004 Datenverarbeitung; Informatik

description: Vorlesungsskript PC-Propädeutikum zu Office Produkten, WORD, EXCEL, ACCESS, Powerpoint, HTML
AHR: from a xenobiotic sensor to a Pattern Recognition Receptor, playing a role in immunity to infection and drug-therapy
Creators: name: Moura-Alves, P.
Publisher: name: Scientific Letters
Year: 2023

description: Background: The interaction between a bacterial pathogen and its host can be viewed as an “arms race” in which each participant continuously responds to the evolving strategies of the other partner. A mechanism allowing bacteria to rapidly adapt to such changing circumstances is provided by density-dependent cell-to-cell communication known as Quorum Sensing (QS). QS involves a hierarchy of signalling molecules, which in pathogenic bacteria is associated with biofilm formation and virulence regulation. Objective: We hypothesized that if a host sensor can detect and differentiate between bacterial QS molecules and their expression patterns, it will allow hosts to customize their immune responses according to the stage and state of infection. Methods: We have implied in vitro and in vivo assays (e.g., mouse, zebrafish) to evaluate how the host senses and responds to bacterial QS. Results: We found that the Aryl Hydrocarbon Receptor (AHR), a well-recognized receptor in the field of Toxicology, plays a role as an Innate Immune sensor. The AHR is able to sense diverse microbial-derived ligands and regulate different host defence mechanisms, according to the status and type of infection [1]. AHR modulation depends on the relative abundances of different QS molecules, whereby their quantitative assessment enables the host to sense bacterial community densities that may have distinct gene expression programs and infection dynamics. Conclusions: This study brought together concepts of immunology, which focused on the mobilization of defence mechanisms that combat invading pathogens, and concepts of toxicology focused on detoxification responses to inactivate toxins. We propose that by spying on bacterial quorum, the AHR acts as a major sensor of infection dynamics, capable of orchestrating host defence according to the status quo of the infection [1, 2]. Furthermore, our studies implicate the AHR in antibiotic resistance, whereby AHR activation by both drugs and infection impacts therapeutic efficacy [3].
description: Scientific Letters, Vol. 1 No. Sup 1 (2023)
Additional file 1: of Intermittent administration of a fasting-mimicking diet intervenes in diabetes progression, restores Î˛ cells and reconstructs gut microbiota in mice
Creators: name: Wei, Siying
name: Han, Ruomei
name: Zhao, Jingyu
name: Wang, Shuo
name: Huang, Meiqin
name: Wang, Yining
name: Chen, Yan
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: Figure S1. Rarefactions curve of gut microbiota in the two groups of mice. Figure S2. Intermittent FMD alters the composition of gut microbiota at species level. Figure S3. Improvement of glucose tolerance and islet area by FMD in type 1 diabetic mice. Table S1. Ingredients of FMD. Table S2. Nutritional information of FMD. Table S3. Nutritional information of normal chow. Table S4. Primer sequences used in RT-PCR with liver tissues. (PDF 695 kb)
unknown acute toxicity of the antibiotic sulfamethoxazole
Creators: name: Diogo, B. S.
name: Rodrigues, S.
name: Antunes, S. C.
Publisher: name: Scientific Letters
Year: 2023

description: Background: Sulfamethoxazole (SMX) is one of the most used antibiotics in the last 50 years, applied to humans, veterinary medicines, and aquaculture purposes ​[1]​. Detected in different environmental matrices this antibiotic can pose a risk to aquatic ecosystems and contribute to the spread of antimicrobial resistance ​[2,3]​. In addition, SMX has already been included in the 3rd Priority Substances Watch List to be monitored in inland surface waters throughout the European Union under the Water Framework Directive ​[2]​. Regarding the available literature, different studies report the toxicity of SMX to several aquatic organisms, however, these data are quite discrepant and incomplete. Objective: Evaluate the acute toxicity effects of SMX in aquatic model organisms from different trophic levels. Methods: Standard acute ecotoxicological assays were performed ​[4–7]​, evaluating the inhibition of the bioluminescence of the bacterium Aliivibrio fischeri, growth inhibition of microalgae Raphidocelis subcapitata and macrophyte Lemna minor, and immobilization and reproductive effects in the microcrustacean Daphnia magna. Additionally, sub-individual parameters were also evaluated in L. minorand D. magna. Results: Overall, the different species showed different sensitivities to SMX, where preliminary results revealed that R. subcapitata was the most sensitive organism. SMX was harmful to A. fischeri [EC50 (30 min) = 79.67 mg/L], and toxic to L. minor [EC50 (7d) = 2.11 mg/L; causing also lipid peroxidation]. In addition, was harmful to D. magna [EC50 (48h) = 68.75 mg/L], causing significant alterations in sub-individual parameters (e.g., neurotoxicity), and reproductive endpoints, namely a decrease in the rate of population increase at 45 mg/L of SMX. Conclusions: These results highlight the effects that SMX can cause in non-target organisms. Considering that the detection of SMX is increasing considerably in various environmental matrices, it is essential to continue monitoring the behavior of this antibiotic in the environment and its long-term effects on ecosystems.
description: Scientific Letters, Vol. 1 No. Sup 1 (2023)
Development of Body Image and Eating Disorder Psychopathology: Normative and Pathological Trajectories
Creators: name: Lacroix, Emilie
Publisher: name: Arts
Year: 2022
Subjects: subject: body image
subject: eating pathology
subject: personality
subject: longitudinal
subject: meta-analysis
subject: development
subject: Psychology
subject: FOS: Psychology

description: Introduction: Body image is a critical area of wellbeing that predicts many important outcomes, including eating pathology. Unfortunately, there is no consensus about what constitutes normative body image development, or how people come to develop negative body image. The objective of this project was to advance understanding of both normative and pathological trajectories of body image and eating pathology development. Method: This dissertation includes a systematic review and meta-analysis (Chapter 2), and two primary longitudinal studies (Chapters 3 and 4). The meta-analysis summarized longitudinal data from 142 samples to characterize normative mean-level change in body image among females and males between ages 6 and 54. The two primary longitudinal studies took a person-centred approach to identify the most common trajectories of body image and eating pathology, and examine their predictors in two samples: a U.S. sample of 760 female twins assessed between ages 11 and 29; and a U.K. sample of 328 girls and 429 boys assessed between ages 11 and 15. Results: The meta-analysis identified gender-moderated patterns of normative body image development: boys showed small fluctuations in overall body image with net-improvements between ages 10 and 24, whereas girls showed worsening body image between ages 10 and 16, but improvements between ages 16 and 24. Mean-level changes were largest between ages 10 and 14, and stabilized by age 24. The two primary studies identified subgroups of boys and girls who deviated considerably from normative patterns of development; pathological subgroups showed greater proneness to stress, anxiety, and negative emotionality, social difficulties, dietary restraint, and lower global self-esteem. Conclusion: These studies advance theories of body image development. First, a critical period may occur slightly earlier than previously believed. Second, girls and boys may both, on average, experience improvements in body image during emerging adulthood. Third, pluripotent transdiagnostic risk factors such as personality characteristics merit increased attention alongside sociocultural variables that specifically increase risk for eating pathology.
Tourism 3.0
Creators: name: Trapp, Valerie
Publisher: name: Stanford Digital Repository
Year: 2023
Subjects: subject: Tourism--Social aspects
subject: Land rights
subject: Nomadism

description: For her capstone project, Valerie Trapp expanded her journalistic work on the impacts of digital nomadism on the Dominican Republic by creating an ArcGIS StoryMap that explores the links between spirituality, digital nomadism, and land enclosure. Examining the case study of a new NFT-based luxury wellness resort in the Dominican Republic, OYA New Earth, she makes an argument for how wellness resorts' understanding of spirituality is marred by the logic of capitalism. Finally, she proposes other ways to relate land and the sacred through the framework of the 'commons.'
RAM analysis of rotary drilling machines
Creators: name: Rahimdel, Mohammad Javad
name: Hoseinie, Hadi
name: Ghodrati, Behzad
Publisher: name: Wroclaw University of Science and Technology, Faculty of Geoengineering, Mining and Geology
Year: 2016
Subjects: Rotary drilling machine, Markov ApproachReliability, Maintainability, availability

description: Mining Science
Achievements in Delivering Library Instruction to ESL Students at a Campus Library
Creators: name: Reed, Emily
Publisher: name: Zenodo
Year: 2022
Subjects: Library Science
international students
library instruction

description: This article celebrates achievements of first-year library instruction for international and ESL students at Penn State Harrisburg. Project Outcome's Instruction Survey is discussed as a tool for collecting affective data at the end of class. Affective goals of library instruction, such as feeling comfortable in library spaces, is also discussed.
description: The Newsletter can be downloaded or viewed in full here: https://repository.ifla.org/handle/123456789/2423
Improved distance determination to M51 from supernovae 2011dh and 2005cs
Creators: name: Vinko, J.
name: Takats, K.
name: Szalai, T.
name: Marion, G. H.
name: Wheeler, J. C.
name: Sarneczky, K.
name: Garnavich, P. M.
name: Kelemen, J.
name: Klagyivik, P.
name: Pal, A.
name: Szalai, N.
name: Vida, K.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The appearance of two recent supernovae, SN 2011dh and 2005cs, both in M51, provides an opportunity to derive an improved distance to their host galaxy by combining the observations of both SNe. We apply the Expanding Photosphere Method to get the distance to M51 by fitting the data of these two SNe simultaneously. In order to correct for the effect of flux dilution, we use correction factors (zeta) appropriate for standard type II-P SNe atmospheres for 2005cs, but find zeta ~ 1 for the type IIb SN 2011dh, which may be due to the reduced H-content of its ejecta. The EPM analysis resulted in D_M51 = 8.4 +/- 0.7 Mpc. Based on this improved distance, we also re-analyze the HST observations of the proposed progenitor of SN 2011dh. We confirm that the object detected on the pre-explosion HST-images is unlikely to be a compact stellar cluster. In addition, its derived radius (~ 277$ R_sun) is too large for being the real (exploded) progenitor of SN 2011dh. The supernova-based distance, D = 8.4 Mpc, is in good agreement with other recent distance estimates to M51.
description: 6 pages, 5 figures, accepted for publication in A&A
Three Essays on Mental Illness at Work
Creators: name: Dumaisnil, Aidan
Publisher: name: Haskayne School of Business
Year: 2022
Subjects: subject: mental illness
subject: mental health
subject: leadership
subject: planning
subject: Education--Business

description: Although there is growing interest in mental health from governmental agencies, employees, and workplaces, Follmer and Jones’ (2018) call for additional research on mental illness suggests that this area of research remains understudied. This dissertation explores mental illness at work in the context of PTSD, leader mental health, and the impact of occupational depression on planning, activation, and performance. After a short overview of mental illness at work, Chapter 2 explores workplace stressors of post-traumatic stress disorder (PTSD) through a systematic review and meta-analysis of 85 studies, finding that workplace job demands, exposure to violence, sexual harassment, bullying, and injury are all positively related to PTSD symptomology. Additional moderator analysis suggests that the measurement of PTSD and employee occupational group affect the relationship between workplace stressors and PTSD symptoms. Chapter 3 investigates leader mental health, providing a comprehensive review of the 33 articles on leader mental health. Folk beliefs of leadership suggest that leaders should have good mental health: they have high job control, are compensated more, enjoy higher socioeconomic status, less bullying, and less injustice. However, despite these positive work aspects, there are organizational factors that would suggest that leaders should suffer from mental health problems, such as increased demands, higher workload and responsibility, work-family and family-work conflict, and the inability to detach from work. This systematic review suggests that leaders are not immune to mental health problems: they experience burnout, stress, depression, anxiety, mental distress, and sleep problems due to a variety of personal and situational factors. Finally, Chapter 4 tests a multilevel model of planning, exploring the impact of occupational depression and interruptions on planning, activation, and performance, where time management planning and contingent planning lead to activation, occupational depression and interruptions moderate those relationships, and activation ultimately leads to performance. Using an experiment combined with experience sampling methods, the results suggest slightly different results at the between-person and within-person levels. However, the consistent finding at both levels was that occupational depression moderates the relationship between time management planning and activation, and between contingent planning and activation.
Effective renormalized multi-body interactions of harmonically confined ultracold neutral bosons
Creators: name: Johnson, P. R.
name: Blume, D.
name: Yin, X. Y.
name: Flynn, W. F.
name: Tiesinga, E.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Physics (quant-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We calculate the renormalized effective 2-, 3-, and 4-body interactions for N neutral ultracold bosons in the ground state of an isotropic harmonic trap, assuming 2-body interactions modeled with the combination of a zero-range and energy-dependent pseudopotential. We work to third-order in the scattering length a defined at zero collision energy, which is necessary to obtain both the leading-order effective 4-body interaction and consistently include finite-range corrections for realistic 2-body interactions. The leading-order, effective 3- and 4-body interaction energies are U3 = -(0.85576...)(a/l)^2 + 2.7921(1)(a/l)^3 + O[(a/l)^4] and U4 = +(2.43317...)(a/l)^3 + O[(ał)^4], where w and l are the harmonic oscillator frequency and length, respectively, and energies are in units of hbar*w. The one-standard deviation error 0.0001 for the third-order coefficient in U3 is due to numerical uncertainty in estimating a slowly converging sum; the other two coefficients are either analytically or numerically exact. The effective 3- and 4-body interactions can play an important role in the dynamics of tightly confined and strongly correlated systems. We also performed numerical simulations for a finite-range boson-boson potential, and it was comparison to the zero-range predictions which revealed that finite-range effects must be taken into account for a realistic third-order treatment. In particular, we show that the energy-dependent pseudopotential accurately captures, through third order, the finite-range physics, and in combination with the multi-body effective interactions gives excellent agreement with the numerical simulations, validating our theoretical analysis and predictions.
description: Updated introduction, correction of a few typos and sign errors