Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan
Creators: name: Hollis, Ben
name: Day, Felix R.
name: Busch, Alexander S.
name: Thompson, Deborah J.
name: Soares, Ana Luiza G.
name: Timmers, Paul R. H. J.
name: Kwong, Alex
name: Easton, Doug F.
name: Joshi, Peter K.
name: Timpson, Nicholas J.
name: Ong, Ken K.
name: Perry, John R. B.
name: Eeles, Rosalind A.
name: Henderson, Brian E.
name: Haiman, Christopher A.
name: Kote-Jarai, Zsofia
name: Schumacher, Fredrick R.
name: Olama, Ali Amin Al
name: Benlloch, Sara
name: Muir, Kenneth
name: Berndt, Sonja I.
name: Conti, David V.
name: Wiklund, Fredrik
name: Chanock, Stephen
name: Gapstur, Susan
name: Stevens, Victoria L.
name: Tangen, Catherine M.
name: Batra, Jyotsna
name: Clements, Judith
name: Gronberg, Henrik
name: Pashayan, Nora
name: Schleutker, Johanna
name: Albanes, Demetrius
name: Wolk, Alicja
name: West, Catharine
name: Mucci, Lorelei
name: Cancel-Tassin, Géraldine
name: Koutros, Stella
name: Sorensen, Karina Dalsgaard
name: Grindedal, Eli Marie
name: Neal, David E.
name: Hamdy, Freddie C.
name: Donovan, Jenny L.
name: Travis, Ruth C.
name: Hamilton, Robert J.
name: Ingles, Sue Ann
name: Rosenstein, Barry S.
name: Lu, Yong-Jie
name: Giles, Graham G.
name: Kibel, Adam S.
name: Vega, Ana
name: Kogevinas, Manolis
name: Penney, Kathryn L.
name: Park, Jong Y.
name: Stanford, Janet L.
name: Cybulski, Cezary
name: Nordestgaard, Børge G.
name: Brenner, Hermann
name: Maier, Christiane
name: Kim, Jeri
name: John, Esther M.
name: Teixeira, Manuel R.
name: Neuhausen, Susan L.
name: De Ruyck, Kim
name: Razack, Azad
name: Newcomb, Lisa F.
name: Lessel, Davor
name: Kaneva, Radka
name: Usmani, Nawaid
name: Claessens, Frank
name: Townsend, Paul A.
name: Gago-Dominguez, Manuela
name: Roobol, Monique J.
name: Menegaux, Florence
name: Khaw, Kay-Tee
name: Cannon-Albright, Lisa
name: Pandha, Hardev
name: Thibodeau, Stephen N.
name: Tilley, Wayne
name: Risbridger, Gail P.
name: Horvath, Lisa
name: Taylor, Renea
name: Hayes, Vanessa
name: Butler, Lisa
name: Yeadon, Trina
name: Eckert, Allison
name: Saunders, Pamela
name: Haynes, Anne-Maree
name: Papargiris, Melissa
name: Srinivasan, Srilakshmi
name: Kedda, Mary-Anne
name: Moya, Leire
name: Agee, Michelle
name: Alipanahi, Babak
name: Auton, Adam
name: Bell, Robert K.
name: Bryc, Katarzyna
name: Elson, Sarah L.
name: Fontanillas, Pierre
name: Furlotte, Nicholas A.
name: Hinds, David A.
name: Huber, Karen E.
name: Kleinman, Aaron
name: Litterman, Nadia K.
name: McIntyre, Matthew H.
name: Mountain, Joanna L.
name: Noblin, Elizabeth S.
name: Northover, Carrie A. M.
name: Pitts, Steven J.
name: Sathirapongsasuti, J. Fah
name: Sazonova, Olga V.
name: Shelton, Janie F.
name: Shringarpure, Suyash
name: Tian, Chao
name: Tung, Joyce Y.
name: Vacic, Vladimir
name: Wilson, Catherine H.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Article
/631/208/205/2138
/631/443/494
/692/163
/692/308/2056
/45/43
article

description: Abstract: The timing of puberty is highly variable and is associated with long-term health outcomes. To date, understanding of the genetic control of puberty timing is based largely on studies in women. Here, we report a multi-trait genome-wide association study for male puberty timing with an effective sample size of 205,354 men. We find moderately strong genomic correlation in puberty timing between sexes (rg = 0.68) and identify 76 independent signals for male puberty timing. Implicated mechanisms include an unexpected link between puberty timing and natural hair colour, possibly reflecting common effects of pituitary hormones on puberty and pigmentation. Earlier male puberty timing is genetically correlated with several adverse health outcomes and Mendelian randomization analyses show a genetic association between male puberty timing and shorter lifespan. These findings highlight the relationships between puberty timing and health outcomes, and demonstrate the value of genetic studies of puberty timing in both sexes.