cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Integrative multi-omics module network inference with Lemon-Tree
Creators: name: Bonnet, Eric
name: Calzone, Laurence
name: Michoel, Tom
Publisher: name: arXiv
Year: 2014
Subjects: subject: Genomics (q-bio.GN)
subject: FOS: Biological sciences

description: Module network inference is an established statistical method to reconstruct co-expression modules and their upstream regulatory programs from integrated multi-omics datasets measuring the activity levels of various cellular components across different individuals, experimental conditions or time points of a dynamic process. We have developed Lemon-Tree, an open-source, platform-independent, modular, extensible software package implementing state-of-the-art ensemble methods for module network inference. We benchmarked Lemon-Tree using large-scale tumor datasets and showed that Lemon-Tree algorithms compare favorably with state-of-the-art module network inference software. We also analyzed a large dataset of somatic copy-number alterations and gene expression levels measured in glioblastoma samples from The Cancer Genome Atlas and found that Lemon-Tree correctly identifies known glioblastoma oncogenes and tumor suppressors as master regulators in the inferred module network. Novel candidate driver genes predicted by Lemon-Tree were validated using tumor pathway and survival analyses. Lemon-Tree is available from http://lemon-tree.googlecode.com under the GNU General Public License version 2.0.
description: minor revision; 13 pages text + 4 figures + 4 tables + 4 pages supplementary methods; supplementary tables available from the authors
Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene
Creators: name: Caron, K. M. I.
name: Smithies, O.
name: Hagaman, J. R.
name: Knowles, J.
name: Uhlir, R.
name: Rockman, H.
name: Mao, L.
name: Cascio, W.
name: Kim, H.-S.
name: James, L. R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Several mouse models have already proved valuable for investigating hypertrophic responses to cardiac stress. Here, we characterize one caused by a well defined single copy transgene, RenTgMK, that genetically clamps plasma renin and thence angiotensin II at high levels. All of the transgenic males develop concentric cardiac hypertrophy with fibrosis but without dilatation. Over half die suddenly aged 6-8 months. Telemetry showed disturbances in diurnal rhythms a few days before death and, later, electrocardiographic disturbances comparable to those in humans with congestive heart failure. Expression of seven hypertrophy-related genes in this and two categorically different models (lack of atrial natriuretic peptide receptor A; overexpression of calsequestrin) were compared. Statistical analyses show that ventricular expressions of the genes coding for atrial natriuretic peptide, β myosin heavy chain, medium chain acyl-CoA dehydrogenase, and adrenomedullin correlate equally well with the degree of hypertrophy, although their ranges of expression are, respectively, 50-, 30-, 10-, and 3-fold.
Graph-based Polya's urn: completion of the linear case
Creators: name: Lima, Yuri
Publisher: name: arXiv
Year: 2014
Subjects: subject: Probability (math.PR)
subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 60K35 (Primary), 37C10 (Secondary)

description: Given a finite connected graph $G$, place a bin at each vertex. Two bins are called a pair if they share an edge of $G$. At discrete times, a ball is added to each pair of bins. In a pair of bins, one of the bins gets the ball with probability proportional to its current number of balls. Previous works proved that when $G$ is not balanced bipartite, the proportion of balls in the bins converges to a point $w(G)$ almost surely. We prove almost sure convergence for balanced bipartite graphs: the possible limit is either a single point $w(G)$ or a closed interval $\mathcal J(G)$.
description: 12 pages
Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine binding
Creators: name: Zhang, W.
name: Colman, R. W.
name: Huai, Q.
name: Wang, H.
name: Ke, H.
name: Robinson, H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Cyclic nucleotide phosphodiesterases (PDEs) are enzymes controlling cellular concentrations of the second messengers cAMP and cGMP. The crystal structure of the catalytic domain of PDE9A2, a member of a PDE family specifically hydrolyzing cGMP, has been determined at 2.23-Å resolution. The PDE9A2 catalytic domain closely resembles the cAMP-specific PDE4D2 but is significantly different from the cGMP-specific PDE5A1, implying that each individual PDE family has its own characteristic substrate recognition mechanism. The different conformations of the H and M loops between PDE9A2 and PDE5A1 imply their less critical roles in nucleotide recognition. The nonselective inhibitor 3-isobutyl-1-methylxanthine (IBMX) binds to a similar subpocket in the active sites of PDE4, PDE5, and PDE9 and has a common pattern of the binding. However, significantly different orientations and interactions of IBMXs are observed among the three PDE families and also between two monomers of the PDE9A2 dimer. The kinetic properties of the PDE9A2 catalytic domain similar to those of full-length PDE9A imply that the N-terminal regulatory domain does not significantly alter the catalytic activity and the IBMX inhibition.
Eine "positive" Auslegung Ijobs im Kontext von HIV/Aids in Südafrika
Creators: name: West, Gerald O.
name: Zengele, Bongi
Publisher: name: Concilium
Year: 1970

description: Concilium, Bd. 40 Nr. 4 (2004): Concilium: Internationale Zeitschrift für Theologie, Band 40, Heft 4
Two-phase pumped cooling system for power electronics; analyses and experimental results
Creators: name:  HENK JAN VAN GERNER
name:   ARNE TE NIJENHUIS
name:   CHANGMIN CAO
name:   IGNACIO CASTRO
name:   DOUGLAS A. PEDROSO
name:   HEROL DSOUZA
Publisher: name: Proceedings of the Aerospace Europe Conference - EUCASS - CEAS - 2023
Year: 2023
Subjects: COOLING
THERMAL CONTROL
POWER ELECTRONICS
MPL
TWO-PHASE
PUMP

description: With the introduction of hybrid-electric propulsion, the amount of electrical power in the next generation of aircraft dramatically increases compared to current architectures. In the EU-funded H2020 EASIER project, the usage of two-phase mechanically pumped loops (MPLs) for cooling of power electronics is analysed. Ammonia and Rl233zd(E) appear as premier candidates for aircraft two-phase cooling systems. In this study, an additively manufactured AlSilOMg coldplate is manufactured and tested, which serves as interface between a DC/DC converter with 4 kW heat dissipation and a cooling fluid. Successful experimental validation of this evaporator is achieved in NLR\' s two-phase test facility.
Developing a science of land change: Challenges and methodological issues
Creators: name: Fox, J.
name: Turner, B. L.
name: Rindfuss, R. R.
name: Walsh, S. J.
name: Mishra, V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Land-change science has emerged as a foundational element of global environment change and sustainability science. It seeks to understand the human and environment dynamics that give rise to changed land uses and covers, not only in terms of their type and magnitude but their location as well. This focus requires the integration of social, natural, and geographical information sciences. Each of these broad research communities has developed different ways to enter the land-change problem, each with different means of treating the locational specificity of the critical variables, such as linking the land manager to the parcel being managed. The resulting integration encounters various data, methodological, and analytical problems, especially those concerning aggregation and inference, land-use pixel links, data and measurement, and remote sensing analysis. Here, these integration problems, which hinder comprehensive understanding and theory development, are addressed. Their recognition and resolution are required for the sustained development of land-change science.
Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor
Creators: name: Jennette, J. C.
name: Kakoki, M.
name: Smithies, O.
name: Takahashi, N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Type I human diabetics and streptozotocin-induced diabetic mice with higher genetically determined levels of angiotensin-converting enzyme have an increased risk of developing nephropathy. However, previous experiments in mice and computer simulations indicate that modest increases in angiotensin-converting enzyme have minimal effects on blood pressure and angiotensin II levels, although bradykinin decreases significantly, inferring that bradykinin is critical for protecting the kidney in diabetics. Here, we confirm this inference by demonstrating that Akita diabetic mice lacking the bradykinin B2 receptor develop overt albuminuria, excreting the equivalent of >550 mg/day albumin in humans, which contrasts with the microalbuminuria (equivalent to <150 mg/day) seen in their simply diabetic littermates. The overt albuminuria is accompanied by a marked increase in glomerular mesangial sclerosis. The importance of bradykinin demonstrated here bears strongly on how current drugs reduce diabetic nephropathy and suggests that B2 receptor-specific agonists merit consideration in this context.
Formation of deletions during double-strand break repair in Drosophila DmBlm mutants occurs after strand invasion
Creators: name: Adams, M. D.
name: McVey, M.
name: Sekelsky, J. J.
name: LaRocque, J. R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Bloom syndrome is a rare disorder associated with cancer predisposition and genomic instability and is caused by loss of the RecQ helicase BLM. The Drosophila ortholog of BLM (DmBlm) is required for accurate repair of DNA double-strand gaps by homologous recombination. Repair products from DmBlm mutants have shorter repair synthesis tract lengths compared to wild type and are frequently associated with deletions flanking the break site. To determine the mechanisms responsible for deletion formation in the absence of DmBlm, we characterized repair after excision of the P{wa} element in various genetic backgrounds. Flies lacking DmRad51 do not have an elevated deletion frequency. Moreover, loss of DmRad51 suppresses deletion formation in DmBlm mutants. These data support a model in which DmBlm acts downstream of strand invasion to unwind a D-loop intermediate to free the newly synthesized strand. In the absence of DmBlm, alternative pathways of D-loop disassembly result in short repair synthesis tracts or flanking deletions. This model explains how RecQ helicases can promote homologous recombination while preventing illegitimate recombination.
Vom Vater der Waisen zum Bruder der Schakale und Gefährten der Strauße
Creators: name: Tamez, Elsa
Publisher: name: Concilium
Year: 1970

description: Concilium, Bd. 40 Nr. 4 (2004): Concilium: Internationale Zeitschrift für Theologie, Band 40, Heft 4
Spectral variability of the IR-source IRAS 01005+7910 optical component
Creators: name: Klochkova, V. G.
name: Chentsov, E. L.
name: Panchuk, V. E.
name: Sendzikas, E. G.
name: Yushkin, M. V.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Highly-resolution optical spectra of the optical component of the IR-source IRAS01005+7910 are used to determine the spectral type of its central star, B1.5$ \pm $0.3, identify the spectral features, and analyze their profile and radial velocity variations. The systemic velocity Vsys =$-50.5$ km/s is determined from the positions of the symmetric and stable profiles of the forbidden [NI], [NII], [OI], [SII], and [FeII] emission lines. The presence of the [NII] and [SII] forbidden emissions indicates the onset of the ionization of the circumstellar envelope and the fact that the star is very close to undergoing the planetary nebula stage. The broad range of heliocentric radial velocity Vr estimates based on the core lines, which amounts to about 34 km/s, is partly due to the deformations of the profiles caused by variable emissions. The variations of the Vr in the line wings are smaller, about 23 km/s, and may be due to pulsations and/or hidden binarity of the star. The deformations of the profiles of complex absorption-emission lines may result from variations of their absorption components caused by the variations of the geometry and kinematics in the wind base. The H$α$ lines exhibit P Cyg III type wind profiles. Deviations of the wind from spherical symmetry are shown to be small. The relatively low wind velocity (27$÷$74 km/s from different observations) and the strong intensity of the red emission (it exceeds the continuum level by up to a factor of seven) are typical for hypergiants rather than the classical supergiants. IRAS01005 +7910 is an example of spectral mimicry of a low mass post-AGB star masquerading as a massive hypergiant.
description: 23 pages, 11 figures, 2 tables
TESE Giulian Sá_PPGBBM_Final.pdf
Creators: name: Sá, Giulian
Publisher: name: figshare
Year: 2022
Subjects: subject: Molecular Biology
subject: Pharmacology
subject: Toxicology
subject: Microbiology
subject: FOS: Biological sciences
subject: 60502 Infectious Agents
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60199 Biochemistry and Cell Biology not elsewhere classified

description: Tephrosia toxicaria (Sw.) Pers. is a legume occurring in the Northeast Brazil that has attracted the attention of researchers because it serves as a matrix to obtain numerous adjuvant formulations for integrated management strategies of vectors and diseases, such as plant extracts, due to its selective toxicity and environmental compatibility. The search for new natural adjuvant formulations for the management of diseases, vectors and pathogens shows that plant extracts are still promising, especially considering the great Brazilian biodiversity, they are obtained from renewable sources, their toxic selectivity to target organisms and environmental compatibility. The development of the present research was stimulated by the possibility of expanding the repertoire of options for natural adjuvants, which aimed to investigate the bioactive potential and biosecurity of aqueous and hydroethanolic extracts from seeds, roots, stems and leaves of T. toxicaria.
Literature Review of Climate Adaptation Using Ecosystem Services, Biodiversity Hotspots and Conservation Priorities and the Natural Environment as an Intrinsic Value and the Duty for Stewardship
Creators: name: Wassmer, Thomas
Publisher: name: figshare
Year: 2020
Subjects: subject: 50202 Conservation and Biodiversity
subject: FOS: Biological sciences
subject: 40104 Climate Change Processes
subject: FOS: Earth and related environmental sciences
subject: 50207 Environmental Rehabilitation (excl. Bioremediation)
subject: 50205 Environmental Management
subject: 50102 Ecosystem Function

description: Should we protect nature and her ecosystems because their ecosystems provide valuable and essential ecosystem services? Should we or do we need to set conservation priorities such as focusing on biodiversity hotspots or should we be ecocentric as nature, ecosystems and other species constitute intrinsic values?
title: Experiments on Melting Around an Isothermal Horizontal Cylinder Under Computer Control
Creators: name: Rothgeb, Timothy Moore
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 1983

description: The melting of a solid around an isothermal horizontal cylinder is a physical phenomenon which must be understood when attempting to design a latent heat storage system. The desire to design such a system is the motivating factor in this research. To gain this understanding of the fundamental melting processes several experiments were designed, and two sets of Stefan and Rayleigh number experiments were undertaken. Experiments were also performed to determine the properties of the paraffin that was used in these investigations. During the investigations of the melting processes, the temperature was measured at several locations throughout the liquid and solid phases. The interface position was also determined photographically at several times during the experiments. These results are compared favorably with recently published numerical solutions to the governing equations. The results also show that both the interface and the temperature field data are symmetric with respect to the vertical gravitational field of force.
Māori knowledge under the microscope: Appropriation and patenting of mātauranga Māori and related resources
Creators: name: Lai, Jessica
name: Robinson, Daniel F
name: Stirrup, Tim
name: Tualima, Saeymalo
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2023
Subjects: subject: Law
subject: FOS: Law

description: No description supplied
High-precision Estimate of the Critical Exponents for the Directed Ising Universality Class
Creators: name: Park, Su-Chan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: With extensive Monte Carlo simulations, we present high-precision estimates of the critical exponents of branching annihilating random walks with two offspring, a prototypical model of the directed Ising universality class in one dimension. To estimate the exponents accurately, we propose a systematic method to find corrections to scaling whose leading behavior is supposed to take the form $t^{-χ}$ in the long-time limit at the critical point. Our study shows that $χ\approx 0.75$ for the number of particles in defect simulations and $χ\approx 0.5$ for other measured quantities, which should be compared with the widely used value of $χ= 1$. Using $χ$ so obtained, we analyze the effective exponents to find that $β/ν_\| = 0.2872(2)$, $z = 1.7415(5)$, $η= 0.0000(2)$, and accordingly, $β/ν_\perp = 0.5000(6)$. Our numerical results for $β/ν_\|$ and $z$ are clearly different from the conjectured rational numbers $β/ν_\| = \frac{2}{7} \approx 0.2857$, $z = \frac{7}{4}= 1.75$ by Jensen [Phys. Rev. E, {\bf 50}, 3623 (1994)]. Our result for $β/ν_\perp$, however, is consistent with $\frac{1}{2}$, which is believed to be exact.
Magnetic anisotropy of critical current in nanowire Josephson junction with spin-orbit interaction
Creators: name: Yokoyama, Tomohiro
name: Nazarov, Yuli V.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We develop and study theoretically a minimal model of semiconductor nanowire Josephson junction that incorporates Zeeman and spin-orbit effects. The DC Josephson current is evaluated from the phase-dependent energies of Andreev levels. Upon changing the magnetic field applied, the critical current oscillates manifesting cusps that signal the $0$-$π$ transition. Without spin-orbit interaction, the oscillations and positions of cusps are regular and do not depend on the direction of magnetic field. In the presence of spin-orbit interaction, the magnetic field dependence of the current becomes anisotropic and irregular. We investigate this dependence in detail and show that it may be used to characterize the strength and direction of spin-orbit interaction in experiments with nanowires.
description: submitted to EPL. The manuscript has a supplementary note. 5 page with 4 figures + 2 pages with 2 figures
Fourier transform ion cyclotron resonance MS reveals the presence of a water molecule in an enzyme transition-state analogue complex
Creators: name: Schroeder, G. K.
name: Short, S. A.
name: Snider, M. J.
name: Wolfenden, R.
name: Borchers, C. H.
name: Speir, J. P.
name: Marquez, V. E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: The structures of several powerful inhibitors of hydrolytic enzymes resemble that of the altered substrate in the transition state, except that a hydrogen atom replaces one substituent (typically the leaving group). To test the hypothesis that a water molecule might be present in the gap resulting from this replacement, we examined a transition-state analogue complex formed by Escherichia coli cytidine deaminase by Fourier transform ion cyclotron resonance MS in electrospray mode. Upon nebularization from aqueous solution under conditions (pH 5.6) where the enzyme is active, cytidine deaminase remains dimeric in the vapor phase. In the presence of inhibitor, the enzyme's exact mass can be used to infer the presence at each active site of zinc, 5-fluoro-3,4-dihydrouridine, and a single water molecule.
Glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme, is required for sperm motility and male fertility
Creators: name: O'Brien, D. A.
name: Perreault, S. D.
name: Eddy, E. M.
name: Willis, W. D.
name: Qu, W.
name: Miki, K.
name: Goulding, E. H.
name: Strader, L. F.
name: Bunch, D. O.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Although glycolysis is highly conserved, it is remarkable that several unique isozymes in this central metabolic pathway are found in mammalian sperm. Glyceraldehyde 3-phosphate dehydrogenase-S (GAPDS) is the product of a mouse gene expressed only during spermatogenesis and, like its human ortholog (GAPD2), is the sole GAPDH isozyme in sperm. It is tightly bound to the fibrous sheath, a cytoskeletal structure that extends most of the length of the sperm flagellum. We disrupted Gapds expression by gene targeting to selectively block sperm glycolysis and assess its relative importance for in vivo sperm function. Gapds–/– males were infertile and had profound defects in sperm motility, exhibiting sluggish movement without forward progression. Although mitochondrial oxygen consumption was unchanged, sperm from Gapds–/– mice had ATP levels that were only 10.4% of those in sperm from WT mice. These results imply that most of the energy required for sperm motility is generated by glycolysis rather than oxidative phosphorylation. Furthermore, the critical role of glycolysis in sperm and its dependence on this sperm-specific enzyme suggest that GAPDS is a potential contraceptive target, and that mutations or environmental agents that disrupt its activity could lead to male infertility.
Humanized anti-CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon
Creators: name: Martin, R.
name: Bielekova, B.
name: Ohayon, J.
name: McCartin, J.
name: Richert, N.
name: McFarland, H. F.
name: Howard, T.
name: Markovic-Plese, S.
name: Wurfel, J.
name: Waldmann, T. A.
name: Blevins, G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Identifying effective treatment combinations for MS patients failing standard therapy is an important goal. We report the results of a phase II open label baseline-to-treatment trial of a humanized monoclonal antibody against CD25 (daclizumab) in 10 multiple sclerosis patients with incomplete response to IFN-β therapy and high brain inflammatory and clinical disease activity. Daclizumab was very well tolerated and led to a 78% reduction in new contrast-enhancing lesions and to a significant improvement in several clinical outcome measures.
Coupled fluids model in FRW space-time
Creators: name: Myrzakul, Shynaray
name: Myrzakulov, Ratbay
name: Sebastiani, Lorenzo
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this paper, we analyze a two coupled fluids model by investigating several solutions for accelerated universe in flat FRW space-time. One of the fluids can be identified with the matter and the model possesses the standard matter solution also. Beyond the removal of the coincidence problem, we will see how the coupling may change the description of the energy contents of the universe and which features can be aquired with respect to the standard decoupled cases.
description: 13 pages, 2 figures, revised version, accepted in Astrophys.Space Sci
Exclusive Rights of Patent Owners vs Rights of Chattel Owners: the Implied Licence Approach
Creators: name: Lai, Jessica
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2023
Subjects: subject: Law
subject: FOS: Law

description: Everybody who owns a smartphone is the chattel owner of an artefact embodying patented inventions. The extent to which one may use the smartphone depends on the scope of patent rights and the implied licences granted by the patent owners. Little attention has been given to this in New Zealand. This article seeks to address this gap by exploring patentees’ exclusive rights and implied licences and how these play out domestically and internationally. It examines the convoluted case law that traverses the interface between patent exclusive rights and chattel owner rights. The article focuses on New Zealand, but borrows case law from the United Kingdom, Australia and Canada to fill gaps. It surmises that the current law in New Zealand is complicated and fact-dependent, and relatively pro-patentee as opposed to pro-chattel owner. The article concludes by analysing whether an exhaustion model would be simpler and more balanced than the implied licence approach.
Imprint of evolution on protein structures
Creators: name: Dokholyan, N. V.
name: Shakhnovich, E. I.
name: Shakhnovich, B. E.
name: Tiana, G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: We attempt to understand the evolutionary origin of protein folds by simulating their divergent evolution with a three-dimensional lattice model. Starting from an initial seed lattice structure, evolution of model proteins progresses by sequence duplication and subsequent point mutations. A new gene's ability to fold into a stable and unique structure is tested each time through direct kinetic folding simulations. Where possible, the algorithm accepts the new sequence and structure and thus a “new protein structure” is born. During the course of each run, this model evolutionary algorithm provides several thousand new proteins with diverse structures. Analysis of evolved structures shows that later evolved structures are more designable than seed structures as judged by recently developed structural determinant of protein designability, as well as direct estimate of designability for selected structures by thermodynamic sampling of their sequence space. We test the significance of this trend predicted on lattice models on real proteins and show that protein domains that are found in eukaryotic organisms only feature statistically significant higher designability than their prokaryotic counterparts. These results present a fundamental view on protein evolution highlighting the relative roles of structural selection and evolutionary dynamics on genesis of modern proteins.
HRV Biofeedback Training for Children with Behavioural Disorders in New Zealand: Three Case Studies
Creators: name: Pine, Russell
name: Bruckner, Karin
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2023
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Although treatments exist for children with behavioural disorders, they often require significant time and are costly. The current pilot study aimed to conduct a preliminary investigation to examine the feasibility of a brief heart rate variability (HRV) biofeedback intervention for children with behavioural disorders in New Zealand (NZ). Participants included 10 children aged between 6 and 11 years who were referred to secondary mental healthcare services in NZ to treat non compliant and aggressive behaviours. Participants included in the study had at least one diagnosis of attention deficit disorder (ADHD), Oppositional Defiant Disorder (ODD) or Anxiety Disorder (AD). Participants took part in 2 baseline HRV biofeedback sessions to understand how the HRV biofeedback tool HeartMath worked. After these baseline sessions, participants completed between 1 and 10 sessions of the biofeedback tool. We describe in detail case reviews of 3 participants with varied responses. Data is comprised of HeartMath performance and coherence scores, SDQ scores pre-and post-intervention, and clinical observations. Participants' achievement and coherence scores displayed meaningful patterns that seemed to demonstrate that learning was taking place, but SDQ scores did not indicate improvement patterns in socio-emotional or life impact factors. Participants found the biofeedback tool easy to use, and the intervention was easy to implement across environments. Given the need for low cost and accessible interventions, HRV biofeedback training may be a feasible and promising approach to support children with behavioural disorders in developing key self-regulation skills within the NZ context. However, more research is required to explore the potential of biofeedback interventions.
Inhibition of acute graft-versus-host disease with retention of graft-versus-tumor effects by the proteasome inhibitor bortezomib
Creators: name: Liu, H.
name: Murphy, W. J.
name: Sitcheran, R.
name: Blazar, B. R.
name: Barao, I.
name: Serody, J. S.
name: Welniak, L. A.
name: O'Shaughnessy, M. J.
name: Riordan, W.
name: Panoskaltsis-Mortari, A.
name: Wysocki, C.
name: Sun, K.
name: Sayers, T. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Graft-versus-host disease (GVHD) represents a major hurdle impeding the efficacy of allogeneic bone marrow transplantation (BMT). Bortezomib is a proteasome inhibitor that was recently approved for treatment of myeloma. We found that bortezomib potently inhibited in vitro mixed lymphocyte responses and promoted the apoptosis of alloreactive T cells. Bortezomib given at the time of allogeneic BMT in mice resulted in significant protection from acute GVHD. Reductions in GVHD-associated parameters and biological evidence of proteasome inhibition were observed with this regimen but with no adverse effects on long-term donor reconstitution. Assessment of graft-versus-tumor responses in advanced leukemia-bearing mice demonstrated that only the combination of allogeneic BMT and T cells with bortezomib promoted significant increases in survival. Increased cytotoxic T cell killing of the tumor was also observed. Thus, the combination of proteasome inhibition with selective immune attack can markedly increase the efficacy of BMT in cancer.
Supplements to Source scaling and ground motion variability along the East Anatolian Fault
Creators: name: Bindi, Dino
Publisher: name: Zenodo
Year: 2023

description: This folder includes the Supplements to : Source scaling and ground motion variability along the East Anatolian Fault, D. Bindi, R. Zaccarelli, F. Cotton, G. Weatherill, S. R. Kotha. published by The Seismic Record. Description of the files is provided in the README file.
Long-range angular correlations at the LHC with ALICE
Creators: name: Milano, Leonardo
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The observation of long-range correlations on the near and away side -the double ridge- in high-multiplicity p-Pb collisions at sqrt(s_NN) = 5.02 TeV and its similarity to Pb-Pb collisions remains one of the open questions from the p-Pb run at the Large Hadron Collider (LHC). It has been attributed to mechanisms that involve initial-state effects, such as gluon saturation and colour connections forming along the longitudinal direction, and final-state effects, such as parton-induced interactions and collective effects developing in a high-density system possibly formed in these collisions. In order to understand the nature of this double- ridge structure the two-particle correlation analysis has been extended to identified particles. The observed mass dependence in p-Pb resembles the pattern observed in Pb-Pb collisions and is compatible with expectations from hydrodynamics. The subtraction of the long-range structures allows the study of the hadron production belonging to the fragmentation of jets originating from low momentum-transfer scatterings (minijets).
description: contribution to the Quark Matter 2014 conference proceedings
Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I
Creators: name: Kedar, V.
name: Li, H.-H.
name: Arya, R.
name: McDonough, H.
name: Patterson, C.
name: Rockman, H. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Muscle-specific RING finger protein 1 (MuRF1) is a sarcomere-associated protein that is restricted to cardiac and skeletal muscle. In skeletal muscle, MuRF1 is up-regulated by conditions that provoke atrophy, but its function in the heart is not known. The presence of a RING finger in MuRF1 raises the possibility that it is a component of the ubiquitin–proteasome system of protein deg-radation. We performed a yeast two-hybrid screen to search for interaction partners of MuRF1 in the heart that might be targets of its putative ubiquitin ligase activity. This screen identified troponin I as a MuRF1 partner protein. MuRF1 and troponin I were found to associate both in vitro and in vivo in cultured cardiomyocytes. MuRF1 reduced steady-state troponin I levels when coexpressed in COS-7 cells and increased degradation of endogenous troponin I protein in cardiomyocytes. The degradation of troponin I in cardiomyocytes was associated with the accumulation of ubiquitylated intermediates of troponin I and was proteasome-dependent. In vitro, MuRF1 functioned as a ubiquitin ligase to catalyze ubiquitylation of troponin I through a RING finger-dependent mechanism. In isolated cardiomyocytes, MuRF1 reduced indices of contractility. In cardiomyocytes, these processes may determine the balance between hypertrophic and antihypertrophic signals and the regulation of myocyte contractile responses in the setting of heart failure.
Ensemble velocity of non-processive molecular motors with multiple chemical states
Creators: name: Vilfan, Andrej
Publisher: name: arXiv
Year: 2014
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Subcellular Processes (q-bio.SC)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: We study the ensemble velocity of non-processive motor proteins, described with multiple chemical states. In particular, we discuss the velocity as a function of ATP concentration. Even a simple model which neglects the strain-dependence of transition rates, reverse transition rates and nonlinearities in the elasticity can show interesting functional dependencies, which deviate significantly from the frequently assumed Michaelis-Menten form. We discuss how the oder of events in the duty cycle can be inferred from the measured dependence. The model also predicts the possibility of velocity reversal at a certain ATP concentration if the duty cycle contains several conformational changes of opposite directionalities.
description: 7 pages, 6 figures; accepted for publication in Interface Focus
Resistant tissues of modern marchantioid liverworts resemble enigmatic Early Paleozoic microfossils
Creators: name: Wilcox, L. W.
name: Graham, L. E.
name: Cook, M. E.
name: Gensel, P. G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Absence of a substantial pretracheophyte fossil record for bryophytes (otherwise predicted by molecular systematics) poses a major problem in our understanding of earliest land-plant structure. In contrast, there exist enigmatic Cambrian–Devonian microfossils (aggregations of tubes or sheets of cells or possibly a combination of both) controversially interpreted as an extinct group of early land plants known as nematophytes. We used an innovative approach to explore these issues: comparison of tube and cell-sheet microfossils with experimentally degraded modern liverworts as analogues of ancient early land plants. Lower epidermal surface tissues, including rhizoids, of Marchantia polymorpha and Conocephalum conicum were resistant to breakdown after rotting for extended periods or high-temperature acid treatment (acetolysis), suggesting fossilization potential. Cell-sheet and rhizoid remains occurred separately or together depending on the degree of body degradation. Rhizoid break-off at the lower epidermal surface left rimmed pores at the centers of cell rosettes; these were similar in structure, diameter, and distribution to pores characterizing nematophyte cell-sheet microfossils known as Cosmochlaina. The range of Marchantia rhizoid diameters overlapped that of Cosmochlaina pores. Approximately 14% of dry biomass of Marchantia vegetative thalli and 40% of gametangiophores was resistant to acetolysis. Pre- and posttreatment cell-wall autofluorescence suggested the presence of phenolic compounds that likely protect lower epidermal tissues from soil microbe attack and provide dimensional stability to gametangiophores. Our results suggest that at least some microfossils identified as nematophytes may be the remains of early marchantioid liverworts similar in some ways to modern Marchantia and Conocephalum.
Millimetre‐scale pollen analysis of non‐varved lacustrine sediments from Onepoto maar palaeolake, Auckland, reveals distal vegetation responses and landscape recovery following the ~25.5‐ka Ōruanui supereruption, New Zealand
Creators: name: Piva, Stephen
name: Barker, Simon
name: Newnham, Rewi M
name: Rees, Andrew
name: Wilson, Colin
name: Carter, Lionel
name: Iverson, Nels A
name: Läuchli, Benjamin
name: Augustinus, Paul C
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2023
Subjects: subject: 40699 Physical Geography and Environmental Geoscience not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Geology
subject: Archaeology

description: No description supplied
North-south asymmetry of solar dynamo in the current activity cycle
Creators: name: Kitchatinov, L. L.
name: Khlystova, A. I.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: An explanation is suggested for the north-south asymmetry of the polar magnetic field reversal in the current cycle of solar activity. The contribution of the Babcock-Leighton mechanism to the poloidal field generation is estimated using sunspot data for the current activity cycle. Estimations are performed separately for the northern and southern hemispheres. The contribution of the northern hemisphere exceeded considerably that of the southern hemisphere during the initial stage of the cycle. This is the probable reason for the earlier reversal of the northern polar field. The estimated contributions of the Babcock-Leighton mechanism are considerably smaller than similar estimations for the previous activity cycles. A relatively weak (<1G) large-scale polar field can be expected for the next activity minimum.
description: 7 pages (one column), 2 figures, to appear in Astronomy Letters
Nucleon Transversity Distribution in the Continuum and Physical Mass Limit from Lattice QCD
Creators: name: Yao, Fei
name: Walter, Lisa
name: Chen, Jiunn-Wei
name: Hua, Jun
name: Ji, Xiangdong
name: Jin, Luchang
name: Lahrtz, Sebastian
name: Ma, Lingquan
name: Mohanta, Protick
name: Schäfer, Andreas
name: Shu, Hai-Tao
name: Su, Yushan
name: Sun, Peng
name: Xiong, Xiaonu
name: Yang, Yi-Bo
name: Zhang, Jian-Hui
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: 530 Physik

description: We report a state-of-the-art lattice QCD calculation of the isovector quark transversity distribution of the proton in the continuum and physical mass limit using large-momentum effective theory. The calculation is done at four lattice spacings a={0.098,0.085,0.064,0.049}  fm and various pion masses ranging between 220 and 350 MeV, with proton momenta up to 2.8 GeV. The result is nonperturbatively renormalized in the hybrid scheme with self-renormalization, which treats the infrared physics at large correlation distance properly, and extrapolated to the continuum, physical mass, and infinite momentum limit. We also compare with recent global analyses for the nucleon isovector quark transversity distribution.
S-adenosylhomocysteine hydrolase deficiency in a human: A genetic disorder of methionine metabolism
Creators: name: Scukanec-Spoljar, M.
name: Pogribny, I. P.
name: Stabler, S.
name: Pazanin, L.
name: Rados, M.
name: Glenn, B.
name: Mejaski-Bosnjak, V.
name: Fumic, K.
name: Sarnavka, V.
name: Vugrek, O.
name: Baric, I.
name: Zeisel, S.
name: Schulze, A.
name: Finkelstein, J. D.
name: Mudd, S. H.
name: Uzelac, L.
name: Allen, R. H.
name: Cuk, M.
name: James, S. J.
name: Wagner, C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: We report studies of a Croatian boy, a proven case of human S-adenosylhomocysteine (AdoHcy) hydrolase deficiency. Psychomotor development was slow until his fifth month; thereafter, virtually absent until treatment was started. He had marked hypotonia with elevated serum creatine kinase and transaminases, prolonged prothrombin time and low albumin. Electron microscopy of muscle showed numerous abnormal myelin figures; liver biopsy showed mild hepatitis with sparse rough endoplasmic reticulum. Brain MRI at 12.7 months revealed white matter atrophy and abnormally slow myelination. Hypermethioninemia was present in the initial metabolic study at age 8 months, and persisted (up to 784 μM) without tyrosine elevation. Plasma total homocysteine was very slightly elevated for an infant to 14.5–15.9 μM. In plasma, S-adenosylmethionine was 30-fold and AdoHcy 150-fold elevated. Activity of AdoHcy hydrolase was ≈3% of control in liver and was 5–10% of the control values in red blood cells and cultured fibroblasts. We found no evidence of a soluble inhibitor of the enzyme in extracts of the patient's cultured fibroblasts. Additional pretreatment abnormalities in plasma included low concentrations of phosphatidylcholine and choline, with elevations of guanidinoacetate, betaine, dimethylglycine, and cystathionine. Leukocyte DNA was hypermethylated. Gene analysis revealed two mutations in exon 4: a maternally derived stop codon, and a paternally derived missense mutation. We discuss reasons for biochemical abnormalities and pathophysiological aspects of AdoHcy hydrolase deficiency.
HI in the Arp 202 system and its tidal dwarf candidate
Creators: name: Sengupta, Chandreyee
name: Scott, T. C.
name: Dwarakanath, K. S.
name: Saikia, D. J.
name: Sohn, B. W.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present results from our Giant Metrewave Radio Telescope (GMRT) HI observations of the interacting pair Arp 202 (NGC 2719 and NGC 2719A). Earlier deep UV(GALEX) observations of this system revealed a tidal tail like extension with a diffuse object towards its end, proposed as a tidal dwarf galaxy (TDG) candidate. We detect HI emission from the Arp 202 system, including HI counterparts for the tidal tail and the TDG candidate. Our GMRT HI morphological and kinematic results clearly link the HI tidal tail and the HI TDG counterparts to the interaction between NGC 2719 and NGC 2719A, thus strengthening the case for the TDG. The Arp 202 TDG candidate belongs to a small group of TDG candidates with extremely blue colours. In order to gain a better understanding of this group we carried out a comparative study of their properties from the available data. We find that HI (and probably stellar) masses of this extremely blue group are similar to the lowest HI mass TDGs in the literature. However the number of such blue TDG candidates examined so far is too small to conclude whether or not their properties justify them to be considered as a subgroup of TDGs.
description: Accepted in MNRAS
The human Rad9-Rad1-Hus1 checkpoint complex stimulates flap endonuclease 1
Creators: name: Podust, V.
name: Brandt, P.
name: Wang, W.
name: Fanning, E.
name: Bambara, R. A.
name: Lindsey-Boltz, L.
name: Sancar, A.
name: Rossi, M. L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: The toroidal damage checkpoint complex Rad9–Rad1–Hus1 (9-1-1) has been characterized as a sensor of DNA damage. Flap endonuclease 1 (FEN1) is a structure-specific nuclease involved both in removing initiator RNA from Okazaki fragments and in DNA repair pathways. FEN1 activity is stimulated by proliferating cell nuclear antigen (PCNA), a toroidal sliding clamp that acts as a platform for DNA replication and repair complexes. We show that 9-1-1 also binds and stimulates FEN1. Stimulation is observed on a variety of flap, nick, and gapped substrates simulating repair intermediates. Blocking 9-1-1 entry to the double strands prevents a portion of the stimulation. Like PCNA stimulation, 9-1-1 stimulation cannot circumvent the tracking mechanism by which FEN1 enters the substrate; however, 9-1-1 does not substitute for PCNA in the stimulation of DNA polymerase β. This suggests that 9-1-1 is a damage-specific activator of FEN1.
"Ich aber will zum Allmächtigen reden" (Ijob 13,3)
Creators: name: Van Hecke, Pierre Jacques Paul
Publisher: name: Concilium
Year: 1970

description: Concilium, Bd. 40 Nr. 4 (2004): Concilium: Internationale Zeitschrift für Theologie, Band 40, Heft 4
The rate and equilibrium constants for a multistep reaction sequence for the aggregation of superoxide dismutase in amyotrophic lateral sclerosis
Creators: name: Khare, S. D.
name: Caplow, M.
name: Dokholyan, N. V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Mutation-induced aggregation of the dimeric enzyme Cu, Zn superoxide dismutase 1 (SOD1) has been implicated in the familial form of the disease amyotrophic lateral sclerosis, but the mechanism of aggregation is not known. Here, we show that in vitro SOD1 aggregation is a multistep reaction that minimally consists of dimer dissociation, metal loss from the monomers, and oligomerization of the apo-monomers:
Qualitative FAIR Data: Practical Approaches with Atlas.ti and Hypothes.is
Creators: name: Hernández Serrano, Pedro
Publisher: name: Zenodo
Year: 2023

description: Slides of the presentation given at the event "I want to be FAIR - How to deal with my qualitative data?" This presentation explores practical examples of FAIR data management in qualitative research, leveraging tools like Atlas.ti and Hypothes.is. We will explore the advantages and limitations of using data technologies and their impact on qualitative research.
Tax Evasion and Benefit Fraud: A Study of the Use of Techniques of Neutralization
Creators: name: Marriott, Lisa
name: Lai, Jessica
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2023
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: No description supplied