cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Investigation into the site-specific binding interactions between chlorogenic acid and ovalbumin using multi-spectroscopic and in silico simulation studies
Creators: name: Perumal, Manivel
name: Marimuthu, Parthiban
name: Chen, Xiumin
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Computational Biology

description: The binding interactions of bioactive compounds with proteins are of great importance in the food, biochemistry and pharmaceutical fields. Herein, the binding mechanisms between 5-O-caffeoylquinic acid (5-CQA) and ovalbumin (OVA) were investigated by multi-spectroscopic studies combined with docking and molecular dynamics (MD) simulations. The emission intensity of OVA was quenched by 5-CQA and Stern-Volmer analysis indicated the existence of a static suppression by OVA–5-CQA complex formation. Thermodynamic parameters revealed that the formation of complex was spontaneously driven by electrostatic and hydrogen-bonding interactions. Circle dichroism analyses showed that 5-CQA decreased the α-helix content of OVA structure from 58.05% to 54.32% upon increased OVA:5-CQA ratio to 1:3. Molecular docking results suggested 5-CQA forms hydrogen bond interactions with N88, T91, K92, N94, S98, F99, S100 and L101 residues of OVA. The experimental values were in good agreement with the calculated binding free energy values obtained by MD simulation (R2 = 0.89). Communicated by Ramaswamy H. Sarma
The political situation in the western oases of Egypt during the second intermediate period, with special reference to the Dakhleh Oasis
Creators: name: Scorgie, Séamus.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
A Generalization of Sachdev-Ye-Kitaev
Creators: name: Gross, David J.
name: Rosenhaus, Vladimir
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The SYK model: fermions with a $q$-body, Gaussian-random, all-to-all interaction, is the first of a fascinating new class of solvable large $N$ models. We generalize SYK to include $f$ flavors of fermions, each occupying $N_a$ sites and appearing with a $q_a$ order in the interaction. Like SYK, this entire class of models generically has an infrared fixed point. We compute the infrared dimensions of the fermions, and the spectrum of singlet bilinear operators. We show that there is always a dimension-two operator in the spectrum, which implies that, like in SYK, there is breaking of conformal invariance and maximal chaos in the infrared four-point function of the generalized model. After a disorder average, the generalized model has a global $O(N_1) \times O(N_2) \times \ldots\times O(N_f)$ symmetry: a subgroup of the $O(N)$ symmetry of SYK; thereby giving a richer spectrum. We also elucidate aspects of the large $q$ limit and the OPE, and solve $q=2$ SYK at finite $N$.
description: 46 pages, v2 minor changes; published version
Amtliche Mitteilungen der Technischen Universität Dortmund Nr. 19/2015
Creators: name: (:Unkn) Unknown
Publisher: name: Technische Universität Dortmund
Year: 2015
Subjects: subject: 080

description: Fächerspezifische Bestimmungen für den Lernbereich Natur- und Gesellschaftswissenschaften (Sachunterricht) für ein Lehramt an Grundschulen zur Prüfungsordnung für den Lehramtsbachelorstudiengang an der Technischen Universität Dortmund
description: Fächerspezifische Bestimmungen für den Lernbereich Natur- und Gesellschaftswissenschaften (Sachunterricht) für ein Lehramt an Grundschulen zur Prüfungsordnung für den Lehramtsmasterstudiengang an der Technischen Universität Dortmund
description: Fächerspezifische Bestimmungen für den Lernbereich Natur- und Gesellschaftswissenschaften (Sachunterricht) für ein Lehramt für sonderpädagogische Förderung zur Prüfungsordnung für den Lehramtsbachelorstudiengang an der Technischen Universität Dortmund
description: Fächerspezifische Bestimmungen für den Lernbereich Natur- und Gesellschaftswissenschaften (Sachunterricht) für ein Lehramt für sonderpädagogische Förderung zur Prüfungsordnung für den Lehramtsmasterstudiengang an der Technischen Universität Dortmund
description: Amtliche Mitteilungen der Technischen Universität Dortmund;19, 2015
Lüdicke, Klaus: »Dignitas connubii« - Die Eheprozeßordnung der katholischen Kirche
Creators: name: Rothe, Wolfgang F.
Publisher: name: Forum Katholische Theologie
Year: 1970

description: Forum Katholische Theologie, Bd. 23 Nr. 4 (2007): Forum Katholische Theologie, Band 23, Heft 4
Polymer translocation through nano-pores in vibrating thin membranes
Creators: name: Menais, Timothee
name: Mossa, Stefano
name: Buhot, Arnaud
Publisher: name: arXiv
Year: 2016
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: Polymer translocation is a promising strategy for the next-generation DNA sequencing technologies. The use of biological and synthetic nano-pores, however, still suffers from serious drawbacks. In particular, the width of the membrane layer can accommodate several bases at the same time, making difficult accurate sequencing applications. More recently, the use of graphene membranes has paved the way to new sequencing capabilities, with the possibility to measure transverse currents, among other advances. The reduced thickness of these new membranes poses new questions on the effect of deformability and vibrations of the membrane on the translocation process, two features which are not taken into account in the well-established theoretical frameworks. Here, we make a first step forward in this direction. We report numerical simulation work on a model system simple enough to allow gathering significant insight on the effect of these features on the average translocation time, with appropriate statistical significance. We have found that the interplay between thermal fluctuations and the deformability properties of the nano-pore play a crucial role in determining the process. We conclude by discussing new directions for further work.
A subsampled double bootstrap for massive data
Creators: name: Sengupta, Srijan
name: Volgushev, Stanislav
name: Shao, Xiaofeng
Publisher: name: Technische Universität Dortmund
Year: 2015
Subjects: subject: big data
subject: resampling
subject: subsampling
subject: computational cost
subject: 310
subject: 330
subject: 620

description: The bootstrap is a popular and powerful method for assessing precision of estimators and inferential methods. However, for massive datasets which are increasingly prevalent, the bootstrap becomes prohibitively costly in computation and its feasibility is questionable even with modern parallel computing platforms. Recently Kleiner, Talwalkar, Sarkar, and Jordan (2014) proposed a method called BLB (Bag of Little Bootstraps) for massive data which is more computationally scalable with little sacrifice of statistical accuracy. Building on BLB and the idea of fast double bootstrap, we propose a new resampling method, the subsampled double bootstrap, for both independent data and time series data. We establish consistency of the subsampled double bootstrap under mild conditions for both independent and dependent cases. Methodologically, the subsampled double bootstrap is superior to BLB in terms of running time, more sample coverage and automatic implementation with less tuning parameters for a given time budget. Its advantage relative to BLB and bootstrap is also demonstrated in numerical simulations and a data illustration.
description: Discussion Paper / SFB 823;27/2015
Optimal free descriptions of many-body theories
Creators: name: Turner, Christopher J.
name: Meichanetzidis, Konstantinos
name: Papic, Zlatko
name: Pachos, Jiannis K.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Interacting bosons or fermions give rise to some of the most fascinating phases of matter, including high-temperature superconductivity, the fractional quantum Hall effect, quantum spin liquids and Mott insulators. While these systems are promising for technological applications, they also present conceptual challenges as they require approaches beyond mean-field and perturbation theory. Here we develop a general framework for identifying the free theory that is closest to a given interacting model in terms of their ground state correlations. Moreover, we quantify the distance between them using the entanglement spectrum. When this interaction distance is small, the optimal free theory provides an effective description of the low energy physics of the interacting model. Our construction of the optimal free model is non-perturbative in nature, thus it offers a new theoretical framework for investigating strongly correlated systems.
description: 7+2 pages, 4+1 figures
Ecstatic consonance : a third aesthetic in Scriabin's late piano works
Creators: name: Braun, Deniz Lucien.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
On a role of corotation radius in the low $T/W$ dynamical instability of differentially rotating stars
Creators: name: Yoshida, Shin'ichirou
name: Saijo, Motoyuki
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We investigate the nature of so-called low $T/W$ dynamical instability in a differentially rotating star by focusing on the role played by the corotation radius of the unstable oscillation modes. An one dimensional model of linear perturbation, which neglects dependence of variables on the coordinate along the rotational axis of the star, is solved to obtain stable and unstable eigenmodes. A linear eigenmode having a corotation radius, at which azimuthal pattern speed of the mode coincides with the stellar angular velocity, is categorized to either a complex (growing or damping) mode or a purely real mode belonging to a continuous spectrum of frequency. We compute canonical angular momentum and its flux to study eigenmodes with corotation radius. In a dynamically unstable mode, sound wave transports its angular momentum in such a way that the absolute value of the angular momentum is increased on both sides of the corotation radius. We further evaluate growth of amplitude of reflected sound wave incident to a corotation point and find that the over-reflection of the wave and the trapping of it between the corotation radius and the surface of the star may qualitatively explain dependences of eigenfrequencies on the stellar differential rotation. The results suggest that the low $T/W$ instability may be caused by over-reflection of sound waves trapped mainly between the surface of the star and a corotation radius.
description: 14 pages, 14 figures. To appear in MNRAS
Dörner, Reinhard (Hg.): Prüfet die Geister... (1Joh 4,1)
Creators: name: Waste, Gabriele
Publisher: name: Forum Katholische Theologie
Year: 1970

description: Forum Katholische Theologie, Bd. 23 Nr. 4 (2007): Forum Katholische Theologie, Band 23, Heft 4
Investigation of sphingosine kinase 1 inhibitory potential of cinchonine and colcemid targeting anticancer therapy
Creators: name: Roy, Sonam
name: Khan, Shama
name: Jairajpuri, Deeba Shamim
name: Hussain, Afzal
name: Alajmi, Mohamed F.
name: Islam, Asimul
name: Luqman, Suaib
name: Parvez, Suhel
name: Hassan, Md. Imtaiyaz
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Computational Biology

description: Sphingosine kinase 1 (SphK1) and sphingosine-1-phosphate (S1P) signaling regulates numerous diseases such as cancer, diabetes, and inflammation-related ailments, rheumatoid arthritis, atherosclerosis, and multiple sclerosis. The importance of SphK1 in chemo-resistance has been extensively explored in breast, lung, colon, and hepatocellular carcinomas. SphK1 is considered an attractive drug target for the development of anticancer therapy. New drug molecules targeting the S1P signaling are required owing to its pleiotropic nature and association with multiple downstream targets. Here, we have investigated the binding affinity and SphK1 inhibitory potential of cinchonine and colcemid using a combined molecular docking and simulation studies followed by experimental analysis. These compounds bind to SphK1 with a significantly high affinity and subsequently inhibit kinase activity (IC50 7–9 μM). Further, MD simulation studies revealed that both cinchonine and colcemid bind to the residues at the active site pocket of SphK1 with several non-covalent interactions, which may be responsible for inhibiting its kinase activity. Besides, the binding of cinchonine and colcemid causes substantial conformational changes in the structure of SphK1. Taken together, cinchonine and colcemid may be implicated in designing potential drug molecules with improved affinity and specificity for SphK1 targeting anticancer therapy. Communicated by Ramaswamy H. Sarma
Monitoring multivariate variance changes
Creators: name: Pape, Katharina
name: Wied, Dominik
name: Galeano, Pedro
Publisher: name: Technische Universität Dortmund
Year: 2015
Subjects: subject: multivariate sequences
subject: variance changes
subject: threshold function
subject: online detection
subject: 310
subject: 330
subject: 620

description: We propose a model-independent multivariate sequential procedure to monitor changes in the vector of componentwise unconditional variances in a sequence of p-variate random vectors. The asymptotic behavior of the detector is derived and consistency of the procedure stated. A detailed simulation study illustrates the performance of the procedure confronted with different types of data generating processes. We conclude with an application to the log returns of a group of DAX listed assets.
description: Discussion Paper / SFB 823;29/2015
Repurposing of FDA approved drugs and their validation against potential drug targets for Salmonella enterica through molecular dynamics simulation
Creators: name: Kesharwani, Akanksha
name: Chaurasia, Dheeraj Kumar
name: Katara, Pramod
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Salmonella is a widely distributed pathogen causing infection of intestinal tract, typhoid, and paratyphoid fever. Number of drugs was developed against salmonella, but in the last few decades due to the emergence of drug resistant strains, most of these drugs became dormant. As a result Salmonellosis emerges as a trivial cause of human mortality worldwide; therefore, there is an urgent need for unexploited drug targets and drugs to treat Salmonellosis. As development of new drug molecules is very time consuming and costly, drug repurposing is in consideration as a better alternative. With the aim to identify a new drug molecule against the Salmonella through repurposing approach, we utilized 14 well reported druggable targets known to play a vital role in the life cycle of pathogens. These targets were used to screen DrugBank and got 53 FDA approved drugs against them. To find the interaction between considered target proteins and screened drugs, molecular docking was performed. Fourteen docked drug-target complexes with reasonable binding affinities were subjected to Molecular Dynamics Simulation (MDS) at 150 ns, using Amber18. At the end MMPBSA and MMGBSA calculations were performed for all stable complexes and finally, got 3 precise and favourable complexes, i.e. ArcB-Cefpiramide, MrcB-Cefoperazone, and PhoQ-Carindacillin. Rigorous structural and energetic analysis for these complexes validates the potential of drug molecules to act as therapeutic drugs against Salmonella enterica. With this study we hypothesize that the drugs Cefpiramide (DB00430), Cefoperazone (DB01329) and Carindacillin (DB09319) will be the good repurposed-drugs for the treatment of Salmonellosis. Communicated by Ramaswamy H. Sarma
Force-Free Foliations
Creators: name: Compère, Geoffrey
name: Gralla, Samuel E.
name: Lupsasca, Alexandru
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mathematical Physics (math-ph)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Electromagnetic field configurations with vanishing Lorentz force density are known as force-free and appear in terrestrial, space, and astrophysical plasmas. We explore a general method for finding such configurations based on formulating equations for the field lines rather than the field itself. The basic object becomes a foliation of spacetime or, in the stationary axisymmetric case, of the half-plane. We use this approach to find some new stationary and axisymmetric solutions, one of which could represent a rotating plasma vortex near a magnetic null point.
description: 26 pages, 1 figure. v2: minor edits, matches published version
Simulating Siam : case studies in the imaginative colonisation of Thailand
Creators: name: Tripasai, Pornsawan.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
In silico identification and validation of natural antiviral compounds as potential inhibitors of SARS-CoV-2 methyltransferase
Creators: name: Chandra, Anshuman
name: Chaudhary, Meenakshi
name: Qamar, Imteyaz
name: Singh, Nagendra
name: Nain, Vikrant
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: The novel Coronavirus disease 2019 (COVID-19) is potentially fatal and caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Due to the unavailability of any proven treatment or vaccination, the outbreak of COVID-19 is wreaking havoc worldwide. Hence, there is an urgent need for therapeutics targeting SARS-CoV-2. Since, botanicals are an important resource for several efficacious antiviral agents, natural compounds gaining significant attention for COVID-19 treatment. In the present study, methyltranferase (MTase) of the SARS-CoV-2 is targeted using computational approach. The compounds were identified using molecular docking, virtual screening and molecular dynamics simulation studies. The binding mechanism of each compound was analyzed considering the stability and energetic parameter using in silico methods. We have found four natural antiviral compounds Amentoflavone, Baicalin, Daidzin and Luteoloside as strong inhibitors of methyltranferase of SARS-CoV-2. ADMET prediction and target analysis of the selected compounds showed favorable results. MD simulation was performed for four top-scored molecules to analyze the stability, binding mechanism and energy requirements. MD simulation studies indicated energetically favorable complex formation between MTase and the selected antiviral compounds. Furthermore, the structural effects on these substitutions were analyzed using the principles of each trajectories, which validated the interaction studies. Our analysis suggests that there is a very high probability that these compounds may have a good potential to inhibit Methyltransferase (MTase) of SARS-CoV-2 and to be used in the treatment of COVID-19. Further studies on these natural compounds may offer a quick therapeutic choice to treat COVID-19. Communicated by Ramaswamy H. Sarma
Second order optical nonlinearity of graphene due to electric quadrupole and magnetic dipole effects
Creators: name: Cheng, J. L.
name: Vermeulen, N.
name: Sipe, J. E.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We present a practical scheme to separate the contributions of the electric quadrupole-like and the magnetic dipole-like effects to the forbidden second order optical nonlinear response of graphene, and give analytic expressions for the second order op- tical conductivities, calculated from the independent particle approximation, with relaxation described in a phenomenological way. We predict strong second order nonlinear effects, including second harmonic generation, photon drag, and difference fre- quency generation. We discuss in detail the controllability of these effects by tuning the chemical potential, taking advantage of the dominant role played by interband optical transitions in the response.
description: 11 pages, 9 figures
Whirligigs in the expanded field : an exploration of the spatial sensibility of women's installation art
Creators: name: Jury, Anne-Marie.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
title: Perspektivenwechsel als Methode
title: Die Internationale Frauenuniversität ifu
titleType: AlternativeTitle
Creators: name: Bauschke-Urban, Carola
Publisher: name: Hochschuldidaktisches Zentrum der Technischen Universität Dortmund
Year: 2003
Subjects: subject: 370

description: Journal Hochschuldidaktik ; 14. Jahrgang 2003 Heft 1
Structural and magnetic properties of two branches of the Tripod Kagome Lattice family A$_{2}$RE$_{3}$Sb$_{3}$O$_{14}$ (A = Mg, Zn; RE = Pr, Nd, Gd, Tb, Dy, Ho, Er, Yb)
Creators: name: Dun, Z. L.
name: Trinh, J.
name: Lee, M.
name: Choi, E. S.
name: Li, K.
name: Hu, Y. F.
name: Wang, Y. X.
name: Blanc, N.
name: Ramirez, A. P.
name: Zhou, H. D.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We present a systematic study of the structural and magnetic properties of two branches of the rare earth Tripod Kagome Lattice (TKL) family A$_{2}$RE$_{3}$Sb$_{3}$O$_{14}$ (A = Mg, Zn; RE = Pr, Nd, Gd, Tb, Dy, Ho, Er, Yb; here, we use abbreviation \textit{A-RE}, as in \textit{MgPr} for Mg$_{2}$Pr$_{3}$Sb$_{3}$O$_{14}$), which complements our previously reported work on \textit{MgDy}, \textit{MgGd}, and \textit{MgEr} \cite{TKL}. The present susceptibility ($χ_{dc}$, $χ_{ac}$) and specific heat measurements reveal various magnetic ground states, including the non-magnetic singlet state for \textit{MgPr}, \textit{ZnPr}; long range orderings (LROs) for \textit{MgGd}, \textit{ZnGd}, \textit{MgNd}, \textit{ZnNd}, and \textit{MgYb}; a long range magnetic charge ordered state for \textit{MgDy}, \textit{ZnDy}, and potentially for \textit{MgHo}; possible spin glass states for \textit{ZnEr}, \textit{ZnHo}; the absence of spin ordering down to 80 mK for \textit{MgEr}, \textit{MgTb}, \textit{ZnTb}, and \textit{ZnYb} compounds. The ground states observed here bear both similarities as well as striking differences from the states found in the parent pyrochlore systems. In particular, while the TKLs display a greater tendency towards LRO, the lack of LRO in \textit{MgHo}, \textit{MgTb} and \textit{ZnTb} can be viewed from the standpoint of a balance among spin-spin interactions, anisotropies and non-Kramers nature of single ion state. While substituting Zn for Mg changes the chemical pressure, and subtly modifies the interaction energies for compounds with larger RE ions, this substitution introduces structural disorder and modifies the ground states for compounds with smaller RE ions (Ho, Er, Yb).
description: 15 pages, 13 pages
Repurposing of rabeprazole as an anti-Trypanosoma cruzi drug that targets cellular triosephosphate isomerase
Creators: name: García-Torres, Itzhel
name: la Mora, Ignacio De la Mora-De
name: López-Velázquez, Gabriel
name: Cabrera, Nallely
name: Flores-López, Luis Antonio
name: Becker, Ingeborg
name: Herrera-López, Juliana
name: Hernández, Roberto
name: Pérez-Montfort, Ruy
name: Enríquez-Flores, Sergio
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
classificationCode: 29999
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Pharmacology
classificationCode: 39999
subject: Chemical Sciences not elsewhere classified

description: Trypanosoma cruzi is the causative agent of American trypanosomiasis, which mainly affects populations in Latin America. Benznidazole is used to control the disease, with severe effects in patients receiving this chemotherapy. Previous studies have demonstrated the inhibition of triosephosphate isomerase from T. cruzi, but cellular enzyme inhibition has yet to be established. This study demonstrates that rabeprazole inhibits both cell viability and triosephosphate isomerase activity in T. cruzi epimastigotes. Our results show that rabeprazole has an IC50 of 0.4 µM, which is 14.5 times more effective than benznidazole. Additionally, we observed increased levels of methyl-glyoxal and advanced glycation end products after the inhibition of cellular triosephosphate isomerase by rabeprazole. Finally, we demonstrate that the inactivation mechanisms of rabeprazole on triosephosphate isomerase of T. cruzi can be achieved through the derivatization of three of its four cysteine residues. These results indicate that rabeprazole is a promising candidate against American trypanosomiasis.
title: Il sogno anticomunista. Neofascisti italiani in America Latina (1977-1982)
Creators: name: Ruggiero, Vito
Publisher: name: Roma TrE-Press
Year: 2023

description:

A partire da una corposa documentazione proveniente da Cile, Argentina, Paraguay, Stati Uniti e Italia, questo volume si propone di far luce sulle relazioni intercorse tra le ultime dittature militari latinoamericane e i militanti di Ordine Nuovo e Avanguardia Nazionale, principali sigle del neofascismo italiano nonché maggiori responsabili della strategia della tensione. Dal 1977 in poi, molti neofascisti provenienti delle due organizzazioni si diressero in America Latina dove, nel corso degli anni, poterono contare sulla protezione di Cile, Argentina, Bolivia e Paraguay. Attraverso un’analisi complessiva, questo volume tenta di dimostrare come non sia possibile considerare la migrazione neofascista italiana nel subcontinente come un fenomeno unico e lineare a causa delle marcate differenze riscontrabili nei rapporti con ogni singola giunta militare. Al tempo stesso, l’analisi sottolinea la profonda influenza che le dinamiche emisferiche ebbero sulle traiettorie seguite dai neofascisti, i cui rapporti con le singole dittature furono sempre subordinati agli interessi nazionali dei regimi che, di volta in volta, costituivano il loro punto di riferimento istituzionale. Infine, sulla base dei dati raccolti, il volume si interroga sull’effettivo livello di coesione del mondo dell’anticomunismo militante e radicale che, durante la seconda metà degli anni Settanta, appare frastagliato e conflittuale.

description: Il sogno anticomunista. Neofascisti italiani in America Latina (1977-1982)
Finding potent inhibitors against SARS-CoV-2 main protease through virtual screening, ADMET, and molecular dynamics simulation studies
Creators: name: Roy, Rajarshi
name: Sk, Md Fulbabu
name: Jonniya, Nisha Amarnath
name: Poddar, Sayan
name: Kar, Parimal
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Currently, no antiviral drug or vaccine is available to treat COVID-19 caused by SARS-CoV-2. This underscores an urgent need for developing a drug against SARS-CoV-2. The main protease (3CLpro) of SARS-CoV-2 is considered an essential protein for maintaining the viral life cycle and, therefore, a potential target for drug development. In a recent study, 1000 potential ligands were identified for 3CLpro by screening 1.3 billion compounds from the ZINC15 library. In the current study, we have further screened these 1000 compounds using structure-based virtual screening utilizing the Schrödinger suite and identified nine compounds having a docking score of ∼ −11.0 kcal/mol or less. The top 5 hits display good pharmacological profiles revealing better absorption, proper permeability across the membrane, uniform distribution, and non-toxic. The molecular docking study is further complemented by molecular dynamics simulations of the top 5 docked complexes. The binding free energy analyses via the molecular mechanics generalized Born surface area (MM/GBSA) scheme reveals that ZINC000452260308 is the most potent (ΔGbind = −14.31 kcal/mol) inhibitor. The intermolecular van der Waals interactions mainly drive the 3CLpro-ligand association. This new compound may have great potential as a lead molecule to develop a new antiviral drug to fight against COVID-19. Communicated by Ramaswamy H. Sarma
Discourses of masculinity in the 1890s
Creators: name: Brown, Juliet Ann.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Thompson's group F is not strongly amenable
Creators: name: Hartman, Yair
name: Juschenko, Kate
name: Tamuz, Omer
name: Ferdowsi, Pooya Vahidi
Publisher: name: arXiv
Year: 2016
Subjects: subject: Group Theory (math.GR)
subject: FOS: Mathematics

description: We show that Thompson's group $F$ has a topological action on a compact metric space that is proximal and has no fixed points.
description: Accepted to Ergodic Theory and Dynamical Systems
Exploring the cancer-testis antigen BORIS to design a novel multi-epitope vaccine against breast cancer based on immunoinformatics approaches
Creators: name: Mahdevar, Elham
name: Safavi, Ashkan
name: Abiri, Ardavan
name: Kefayat, Amirhosein
name: Hejazi, Seyed Hossein
name: Miresmaeili, Seyed Mohsen
name: Mobarakeh, Vahid Iranpur
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Molecular Biology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Recently, cancer immunotherapy has gained lots of attention to replace the current chemoradiation approaches and multi-epitope cancer vaccines are manifesting as the next generation of cancer immunotherapy. Therefore, in this study, we used multiple immunoinformatics approaches along with other computational approaches to design a novel multi-epitope vaccine against breast cancer. The most immunogenic regions of the BORIS cancer-testis antigen were selected according to the binding affinity to MHC-I and II molecules as well as containing multiple cytotoxic T lymphocyte (CTL) epitopes by multiple immunoinformatics servers. The selected regions were linked together by GPGPG linker. Also, a T helper epitope (PADRE) and the TLR-4/MD-2 agonist (L7/L12 ribosomal protein from mycobacterium) were incorporated by A(EAAAK)3A linker to form the final vaccine construct. Then, its physicochemical properties, cleavage sites, TAP transport efficiency, B cell epitopes, IFN-γ inducing epitopes and population coverage were predicted. The final vaccine construct was reverse translated, codon-optimized and inserted into pcDNA3.1 to form the DNA vaccine. The final vaccine construct was a stable, immunogenic and non-allergenic protein that contained numerous CTL epitopes, IFN-γ inducing epitopes and several linear and conformational B cell epitopes. Also, the final vaccine construct formed stable and significant interactions with TLR-4/MD-2 complex according to molecular docking and dynamics simulations. Moreover, its world population coverage for HLA-I and HLA-II were about 93% and 96%, respectively. Taking together, these preliminary results can be used as an appropriate platform for further experimental investigations. Communicated by Ramaswamy H. Sarma
R. G. Collingwood as a hermeneutic thinker
Creators: name: Vardoulakis, Dimitris.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Optimized Array Index Computation in DSP Programs
Creators: name: Basu, Anupam
name: Leupers, Rainer
name: Marwedel, Peter
Publisher: name: Universität Dortmund
Year: 1998
Subjects: subject: 004

description: An increasing number of components in embedded systems are implemented by software running on embedded processors. This trend creates a need for compilers for embedded processors capable of generating high quality machine code. Particularly for DSPs, such compilers are hardly available, and novel DSP-specific code optimization techniques are required. In this paper we focus on efficient address computation for array accesses in loops. Based on previous work, we present a new and optimal algorithm for address register allocation and provide an experimental evaluation of different algorithms. Furthermore, an efficient and close-to-optimum heuristic is proposed for large problems.
Spritzbetonverstärkte Stahlbetonstützen
Creators: name: Li, Bing
Publisher: name: Universität Dortmund
Year: 2002
Subjects: subject: Stahlbetonstütze
subject: Spritzbetonverstärkung
subject: Stütze
subject: Verstärkung
subject: R. C. columns
subject: shotcrete strengthening
subject: shotcrete gunnite
subject: 620

description: Die nachträgliche Verstärkung von Stahlbetonbauteilen gewinnt weltweit zunehmend an Bedeutung. Verstärkungsmaßnahmen können erforderlich werden, wenn Umnutzungen mit vergrößerten Nutzlasten verbunden sind. Sie können aber auch, beispielsweise in erdbebengefährdeten Regionen, prophylaktisch bzw. nachträglich eingesetzt werden, wenn eine Vorschädigung durch Erdbeben stattgefunden hat.In der vorliegenden Arbeit wird die Traglast von 10 Stahlbetonstützen mit Zulagebewehrung und zeitlich versetzt aufgebrachter Spritzbetonschicht experimentell ermittelt. Ein Bemessungsansatz nach einer Idee von Schäfer wird in modifizierter Form an eigenen und in der Literatur beschriebenen, experimentellen Ergebnissen kalibriert. Der vorliegenden Arbeit liegen Stützen mit quadratischen und kreisrunden Stützenquerschnitten zugrunde; eine Erweiterung des Ansatzes auf Stützen mit Rechteckquerschnitten erscheint möglich.
description: The subsequent strengthening of R. C. columns and beams is of growing importance. Strengthening can become necessary when a change of usage is combined with increased live loads. Strengthening can also be required in seismic zones either as a prophylactic means or as a subsequent rehabilitation measure.In this paper the load carrying capacity of 10 R. C. columns with additional reinforcement and shotcrete layer is experimentally determined. An approach for a theoretical determination of the ultimate load according to a proposal of Schäfer is calibrated at experimental test results of the author himself an others. The investigations relate to R. C. columns with square and circular sections; an extension of the approach to columns with rectangular sections appears possible.
Influencing a nation: how a leader’s interpersonal emotion regulation influences citizen compliance via trust and emotions during a global pandemic
Creators: name: Naughton, Bernadette
name: O'SHEA, DEIRDRE
name: van der Werff, Lisa
name: Buckley, Finian
Publisher: name: University of Limerick
Year: 2023
Subjects: Industrial and employee relations

description: During crises like the COVID-19 pandemic, it was necessary for political leaders to influence citizens to comply with public health measures and restrictions. These health measures (e.g., physical distancing, staying at home) had substantial negative effects on individuals’ lives and thus were sometimes met with defensive, noncooperative responses. To influence citizens’ compliance with public health guidance and nationally imposed restrictions, political leaders needed to effectively motivate them through their public communications. We argue that while negative emotions may have discouraged citizens from deviating from public health restrictions, other factors such as citizens’ trust in political leaders played a role as well. We investigated whether the perception of the interpersonal emotion regulation (IER) strategies used by government leaders in ministerial briefings impacted citizens’ compliance intentions via either negative affect or perceived trustworthiness. Across three studies based in Western Europe (Studies 1 and 2 survey, Study 3 experimental), we consistently found that a leader’s affect-improving IER strategies increased compliance intentions via perceived trustworthiness but not via negative affect. Affect-worsening IER strategies demonstrated either no effect or an indirect worsening effect on the compliance intentions of citizens. Our findings highlight the importance of IER strategies in ministerial briefings and perceived trustworthiness of political leaders in motivating citizens to comply with public health restrictions during a pandemic.
Amtliche Mitteilungen der Technischen Universität Dortmund Nr. 12/2008
Creators: name: (:Unkn) Unknown
Publisher: name: Technische Universität Dortmund
Year: 2008
Subjects: subject: 080

description: Zweite Ordnung zur Änderung der Regeln guter wissenschaftlicher Praxis der Universität Dortmund (AM 14/03 vom 18.12.2003) in der Fassung vom 24.04.2008 (AM 07/08 vom 29.04.2008
description: Amtliche Mitteilungen der Technischen Universität Dortmund ; 12, 2008
title: Ганзейский союз: от зарождения к возрождению: сборник статей Международной научной конференции молодых ученых
Creators: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: В сборник включены статьи, представленные в рамках Международной конференции молодых ученых «Ганзейский союз: от зарождения к возрождению», состоявшейся 23–24 сентября 2021 года в Новгородском государственном университете имения Ярослава Мудрого, город Великий Новгород.
В ходе работы конференции были представлены доклады, содержащие актуальные исследования, касающиеся развития отношений городов русского Северо-Запада с государствами Балтийского региона. Наибольшее внимание было уделено истории русско-ганзейских торговли, однако были подняты вопросы археологического изучения Новгородской земли, а также проблемы, связанные с функционированием восточноевропейского товарообмена.
Сборник предназначен для широкого круга лиц, интересующихся историей балтийского экономического пространства периода Средневековья и раннего Нового времени.
Transient Instability of Rapidly Rotating Black Holes
Creators: name: Gralla, Samuel E.
name: Zimmerman, Aaron
name: Zimmerman, Peter
Publisher: name: arXiv
Year: 2016
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We analytically study the linear response of a near-extremal Kerr black hole to external scalar, electromagnetic, and gravitational field perturbations. We show that the energy density, electromagnetic field strength, and tidal force experienced by infalling observers exhibit transient growth near the horizon. The growth lasts arbitrarily long in the extremal limit, reproducing the horizon instability of extremal Kerr. We explain these results in terms of near-horizon geometry and discuss potential astrophysical implications.
description: 8 pages. 1 figure. Minor revisions to match published version
OSCAR Well-being Mentoring Program
Creators: name: Borges, Carolina Oliveira
name: Gonçalves, Francisco Valente
name: Gaspar, Inês
name: Jesus, Joana
Publisher: name: Zenodo
Year: 2022
Subjects: mental wellbeing
mentoring guidelines
edoer
personalised learning
wellbeing mentoring

description: This document describes the well-being mentoring principles and guidelines of the OSCAR project. The main purpose and goal of the OSCAR well-being mentoring program is to support mental health, and the developing of well-being competencies and skills. Based on the OSCAR well-being framework, the well-being skills are: (1) Finding Meaning in Life, (2) Finding Meaning at Work, (3) Awareness of Well-being, (4) Recognizing and Understanding Emotions, (5) Emotion Regulation, (6) Stress Management, (7) Setting goals, (8) Psychological Resilience, (9) Accountability, (10) Finding a Work-Life Balance, (11) Strengthening Social Relationships, (12) Assertive Communication, (13) Interpersonal and Social Empathy, (14) Dealing with Perfectionism, (15) Promoting Self-Kindness, and (16) Increasing Self-Confidence. More information on the project: http://oscar-ai.eu/ Learning and mentoring platform: http://edoer.eu/ Mental health training programme: https://learn.edoer.eu/items/journey/45
description: The OSCAR project and this deliverable was supported by the European Commission Erasmus Plus programme. Project id: 2020-1-DE01-KA203-005713
Super-Planckian Spatial Field Variations and Quantum Gravity
Creators: name: Klaewer, Daniel
name: Palti, Eran
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We study scenarios where a scalar field has a spatially varying vacuum expectation value such that the total field variation is super-Planckian. We focus on the case where the scalar field controls the coupling of a U(1) gauge field, which allows us to apply the Weak Gravity Conjecture to such configurations. We show that this leads to evidence for a conjectured property of quantum gravity that as a scalar field variation in field space asymptotes to infinity there must exist an infinite tower of states whose mass decreases as an exponential function of the scalar field variation. We determine the rate at which the mass of the states reaches this exponential behaviour showing that it occurs quickly after the field variation passes the Planck scale.
description: 10pp; v2: Expanded discussions to improve clarity, published version. v3: improved discussion, results unchanged
"Continuous" Integration of Scientific Software (in Computational Science and Engineering)
Creators: name: Maric, Tomislav
name: Tolle, Tobias
name: Lehr, Jan-Patrick
name: Pappagianidis, Ioannis
name: Bothe, Dieter
name: Bischof, Christian
Publisher: name: Zenodo
Year: 2021
Subjects: software engineering
research data management
continuous integration
research software

description: A presentation describing the use of Continuous Integration for scientific (research) software in Computational Science and Engineering
Locating the links between John Cage and the early avant-garde (1909-1933) : a comparative study
Creators: name: Goodwin, Russell.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Amtliche Mitteilungen der Technischen Universität Dortmund Nr. 13/2008
Creators: name: (:Unkn) Unknown
Publisher: name: Technische Universität Dortmund
Year: 2008
Subjects: subject: 080

description: Berichtigung der 2. Änderung der Promotionsordnung der Fakultät Maschinenbau vom 30.03.2006 (AM Nr. 4/2006 S. 18)
description: Erste Ordnung zur Änderung der Fächerspezifischen Bestimmung für das Fach Mathematik zur Prüfungsordnung für den Bachelor-Studiengang mit fachwissenschaftlichem Profil im Modellversuch "Gestufte Studiengänge in der Lehrerbildung" an der Universität Dortmund vom 28.08.2008
description: Erste Ordnung zur Änderung der Richtlinien für die Erteilung und Vergütung von Lehraufträgen an der Technischen Universität Dortmund vom 28.07.2008
description: Verwaltungs- und Benutzungsordnung für das Institut "Raumplanung International" (englisch: "International Spatial Planning Centre Dortmund" – "ISPC Dortmund") an der Fakultät Raumplanung der Technischen Universität Dortmund vom 28.08.2008
description: Amtliche Mitteilungen der Technischen Universität Dortmund ; 13, 2008