cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Rechtsstaat und Richterstaat
Creators: name: Henning, Rudolf
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2013
Subjects: Recht; Staat; Richter; Judikative; Demokratie; Freiheit; Gewalt; Naturrecht; Urteil; Amt

description: [Abstract fehlt]
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 3 (1962): Jahrbuch für Christliche Sozialwissenschaften 03 (1962)
Von der "happiness" zum Wohlfahrtsstaat
Creators: name: Briefs, Goetz
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2013
Subjects: Glück; Wohlfahrt; Staat; Geschichte; Entwicklung; Idee; happiness; welfare; Kapitalismus; Prägung; Struktur; Grenze; Dialektik

description: [Abstract fehlt]
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 3 (1962): Jahrbuch für Christliche Sozialwissenschaften 03 (1962)
Die Mitarbeiter der Festschrift
Creators: name: Höffner, Joseph
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2013

description: [Abstract fehlt]
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 3 (1962): Jahrbuch für Christliche Sozialwissenschaften 03 (1962)
E02457: Gregory of Tours, in his Glory of the Confessors (7), tells how *Martin (ascetic and bishop of Tours, ob. 397, S00050) raised a fallen tree in a village of the Touraine; people have stripped the bark of the tree, dissolved it in water and thereby acquired a medicine. Written in Latin in Tours (north-west Gaul), 587/588.
Creators: name: Kwojtalik
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: Gregory of Tours, Glory of the Confessors 7

Fuit et in Nobiliacense pago urbis Turonicae arbor, quae ab inpulsu venti ruens, viam publicam inpedibat. Quod iter cum vir beatus ageret et ob ruinam arboris clausam cerneret viam, motus misericordia, facto desuper signo crucis, erexit eam. Quae usque nunc stare iuxta viam erecta visa est; etiam praemortua, quia spoliata [a] cortice, vivebat tamen honore viri Dei. De quo cortice multi fideliter eradentes, ut dilutam aquam sumebant, mox medicamina capiebant. Vidimus etiam nos hanc arborem erectam.

'In Neuillé-le-Lierre, a village in the territory of Tours, there was a tree that fell over during a strong wind and blocked the public road. When the blessed Martin was traveling on this road and noted that the way was blocked by this fallen tree, he was moved by pity. He made the sign of the cross over the tree and raised it up. Still today this tree is seen to stand up straight next to the road. But even though it is dead because it has been stripped of its bark, it always lives to the honor of this man of God. Many people have faithfully scraped at its bark, and after they have taken and dissolved the bark in water, soon they received a medicine. I myself have seen this tree standing erect.'

Text: Krusch 1969, 303. Translation: Van Dam 2004, 8.
Incorporation of doxorubicin into plant-derived nanovesicles: process monitoring and activity assessment
Creators: name: Steć, Aleksandra
name: Targońska, Monika
name: Jaikishan, Shishir
name: Chen, Rui
name: Mucha, Piotr
name: Czyrski, Grzegorz S.
name: Jasiecki, Jacek
name: Płoska, Agata
name: Heinz, Andrea
name: Wiedmer, Susanne K.
name: Kalinowski, Leszek
name: Waleron, Krzysztof
name: Wielgomas, Bartosz
name: Dziomba, Szymon
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Extracellular vesicles (EVs) are an experimental class of drug carriers. Alternative sources of EVs are currently being explored to overcome limitations related to their manufacturing from mesenchymal stem cells. In this work, Citrus limon-derived EVs were tested as carriers for the widely used chemotherapeutic drug – doxorubicin (DOX). Capillary electrophoresis (CE) and nanoplasmonic sensing (NPS) were developed for the quality control of DOX–EV preparations. It was found that the CE method enables simultaneous detection of free and incorporated DOX and allows assessing the stability of the preparations and the drug leakage. NPS, on the other hand, demonstrated that DOX is accumulated in the interfacial region of the carrier. The activity of DOX-loaded EVs was tested on HeLa (cervical cancer cells) and HEK293T (human embryonic kidney cells) cell lines. It was found that DOX incorporation into plant-derived EVs virtually does not affect the drug’s cytotoxicity to HeLa cells but significantly decreases DOX activity against HEK293T cell line.
Additional file 2 of Up-to-date quality survey and evaluation of neonatal screening programs in China
Creators: name: Zhang, Jinming
name: Jin, Lizi
name: Feng, Penghui
name: Fei, Yu
name: Li, Wen
name: Jiang, Ting
name: Zhang, Zehao
name: He, Falin
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Cell Biology
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Science Policy

description: Supplementary Material 2
Development of a single-dose Q fever vaccine with an injectable nanoparticle-loaded hydrogel: effect of sustained co-delivery of antigen and adjuvant
Creators: name: Wang, Lu
name: Ramirez, Aaron
name: Felgner, Jiin
name: Li, Enya
name: Hernandez-Davies, Jenny E.
name: Gregory, Anthony E.
name: Felgner, Philip L.
name: Mohraz, Ali
name: Davies, D. Huw
name: Wang, Szu-Wen
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Q fever is a zoonotic infectious disease caused by Coxiella burnetii, and there is currently no FDA-approved vaccine for human use. The whole-cell inactivated vaccine Q-VAX, which is only licensed in Australia, has a risk of causing severe adverse reactions, making subunit vaccines a good alternative. However, most subunit antigens are weak immunogens and require two or more immunizations to elicit an adequate level of immunity. We hypothesized that by combining a nanoparticle to co-deliver both a protein antigen and an adjuvant, together with a hydrogel depot for sustained-release kinetics, a single-administration of a nanoparticle-loaded hydrogel vaccine could elicit a strong and durable immune response. We synthesized and characterized a protein nanoparticle (CBU-CpG-E2) that co-delivered the immunodominant protein antigen CBU1910 (CBU) from C. burnetii and the adjuvant CpG1826 (CpG). For sustained release, we examined different mixtures of PLGA-PEG-PLGA (PPP) polymers and identified a PPP solution that was injectable at room temperature, formed a hydrogel at physiological temperature, and continuously released protein for 8 weeks in vivo. Single-dose vaccine formulations were administered to mice, and IgG, IgG1, and IgG2c levels were determined over time. The vaccine combining both the CBU-CpG-E2 nanoparticles and the PPP hydrogel elicited a stronger and more durable humoral immune response than the soluble bolus nanoparticle vaccines (without hydrogel) and the free antigen and free adjuvant-loaded hydrogel vaccines (without nanoparticles), and it yielded a balanced IgG2c/IgG1 response. This study demonstrates the potential advantages of using this modular PPP hydrogel/nanoparticle system to elicit improved immune responses against infectious pathogens. Schematic representation of in vivo hydrogel depot vaccine formulation and resulting humoral immune responses
sj-pdf-1-lup-10.1177_0961203320984231 - Supplemental material for Low expression of estrogen receptor β in renal tubular epithelial cells may cause hyperuricemia in premenopausal patients with systemic lupus erythematosus
Creators: name: Haijun Liu
name: Liqin Peng
name: Jianda Ma
name: Liping He
name: Kangxia Long
name: Ouyang, Xia
name: Cuiyi Wu
name: Minyan Xie
name: Dai, Lie
name: Xiaoyan Cai
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111702 Aged Health Care
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-1-lup-10.1177_0961203320984231 for Low expression of estrogen receptor β in renal tubular epithelial cells may cause hyperuricemia in premenopausal patients with systemic lupus erythematosus by Haijun Liu, Liqin Peng, Jianda Ma, Liping He, Kangxia Long, Xia Ouyang, Cuiyi Wu, Minyan Xie, Lie Dai and Xiaoyan Cai in Lupus
sj-pdf-4-asp-10.1177_0003702820979052 - Supplemental material for Upconversion Fluorescence in Naturally Occurring Calcium Fluoride
Creators: name: Moffatt, Jillian Elizabeth
name: Payten, Thomas Bede
name: Tsiminis, Georgios
name: Prinse, Thomas Jacob De
name: Teixeira, Lewis Da Silva
name: Klantsataya, Elizaveta
name: Ottaway, David John
name: Smith, Barnaby Whitmore
name: Spooner, Nigel Antony
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies

description: Supplemental material, sj-pdf-4-asp-10.1177_0003702820979052 for Upconversion Fluorescence in Naturally Occurring Calcium Fluoride by Jillian Elizabeth Moffatt, Thomas Bede Payten, Georgios Tsiminis, Thomas Jacob de Prinse, Lewis Da Silva Teixeira, Elizaveta Klantsataya, David John Ottaway, Barnaby Whitmore Smith and Nigel Antony Spooner in Applied Spectroscopy
Die Stellung weiblicher Berufsschüler zu ihrer Arbeit und zu ihrem Beruf
Creators: name: Wessel, Martha
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2013
Subjects: Frau; Mädchen; Beruf; Schülerin; Arbeit; Stellung; Position; Wandel; Tätigkeit; Reifung; Entwicklung; Bedeutung; Sicherheit; Unabhänigkeit; Verdienst

description: [Abstract fehlt]
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 5 (1964): Jahrbuch für Christliche Sozialwissenschaften 05 (1964)
Exploring the efficacy and constraints of platinum nanoparticles as adjuvant therapy in silicosis management
Creators: name: Ban, Ge
name: Chen, Yuanjie
name: Liang, Yingbing
name: Wang, Xiaona
name: Ding, Dan
name: Liu, Rui
name: Jia, Jingjing
name: Zhao, Ran
name: Wang, Chenxia
name: Li, Na
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Virology

description: Silicosis represents a formidable occupational lung pathology precipitated by the pulmonary assimilation of respirable crystalline silica particulates. This condition engenders a cascade of cellular oxidative stress via the activation of bioavailable silica, culminating in the generation of reactive oxygen species (ROS). Such oxidative mechanisms lead to irrevocable pulmonary impairment. Contemporary scholarly examinations have underscored the substantial antioxidative efficacy of platinum nanoparticles (PtNPs), postulating their utility as an adjunct therapeutic modality in silicosis management. The physicochemical interaction between PtNPs and silica demonstrates a propensity for adsorption, thereby facilitating the amelioration and subsequent pulmonary clearance of silica aggregates. In addition to their detoxifying attributes, PtNPs exhibit pronounced anti-inflammatory and antioxidative activities, which can neutralize ROS and inhibit macrophage-mediated inflammatory processes. Such attributes are instrumental in attenuating inflammatory responses and forestalling subsequent lung tissue damage. This discourse delineates the interplay between ROS and PtNPs, the pathogenesis of silicosis and its progression to pulmonary fibrosis, and critically evaluates the potential adjunct role of PtNPs in the therapeutic landscape of silicosis, alongside a contemplation of the inherent limitations associated with PtNPs application in this context.
Autonomie. Von den Implikationen eines politisch-moralischen Ideals in Humangenetik und Neurowissenschaften
Creators: name: Hildt, Elisabeth
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2004
Subjects: Bioethik; Autonomie; Medizin; Medizinethik; Arzt; Patient; Wissenschaft; Neurowissenschaft; Genetik

description: [Abstract fehlt]
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 45 (2004): Gesellschaftsbilder im Diskurs der Wissenschaften
Additional file 3 of Up-to-date quality survey and evaluation of neonatal screening programs in China
Creators: name: Zhang, Jinming
name: Jin, Lizi
name: Feng, Penghui
name: Fei, Yu
name: Li, Wen
name: Jiang, Ting
name: Zhang, Zehao
name: He, Falin
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Cell Biology
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Science Policy

description: Supplementary Material 3
Nach dem Patriarchat. Gesellschaftskritik und Gesellschaftskonzeptionen im Feminismus
Creators: name: Schnabl, Christa
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2004
Subjects: Feminismus; Gesellschaft; Kritik; Bewegung; Geschlecht; Politik; Gerechtigkeit; Vertrag; Freiheit; Gleichheit

description: [Abstract fehlt]
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 45 (2004): Gesellschaftsbilder im Diskurs der Wissenschaften
E02459: Coptic sale of a house, from Jeme (Upper Egypt), a property previously donated to Abba *Viktor (probably the Egyptian martyr, son of Romanos, S00749) at Jeme, for the salvation of the donor's soul, dated 8 November 756.
Creators: name: Bryan
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: P.KRU 15

In this document a man named Daminaos, son of Kosma, seemingly a private individual, is selling an entire house to Aaron, son of Shenoute (see the same man who buys parts of two houses at E02458). Both men are inhabitants of Jeme. The house in question is referred to as having been previously donated as an offering to the martyr saint Apa Victor by a man named Pahom, son of George, for the salvation of the donor's soul. The price paid for the house was four gold solidi.

Lines 30–38 read as follows:

ⲁⲩⲱ ⲉⲓⲥϩⲁⲓ ⲛⲁⲕ ϫⲓⲛ ⲙⲡⲟⲟⲩ ⲁⲩⲱ ϫⲓⲛ ⲧⲉⲛⲟⲩ ϣⲁ ⲉⲛⲉϩ ⲙⲡⲏⲓ ⲧⲏⲣϥ ⲉⲧϩⲓ ⲡϩⲓⲣ ⲛⲛⲣⲙⲡϣⲟⲩⲙⲁⲣⲉ ⲡⲁⲓ ⲛⲧⲁϥⲇⲱⲣⲓⲍⲉ
ⲙⲙⲟϥ ⲉϩⲟⲩⲛ ⲉⲡⲁⲑⲗⲟⲫⲟⲣⲟⲥ ⲁⲩⲱ ⲡⲛⲓⲕⲟⲫⲟⲣⲟⲥ ⲁⲩⲱ ⲥⲧⲉⲫⲁⲛⲟⲫⲟⲣⲟⲥ ⲡⲕⲁⲗⲛⲓⲕⲟⲥ ⲁⲩⲱ ⲡⲙⲁⲣⲧⲩⲣⲟⲥ ⲉⲧⲣⲟⲩⲟⲉⲓⲛ
ⲉⲃⲟⲗ ⲡϩⲁⲅⲓⲟⲥ ⲁⲃⲃⲁ ⲃⲓⲕⲧⲱⲣ ⲙⲡⲕⲁⲥⲧⲣⲟⲛ ⲛϫⲏⲙⲉ ϩⲁ ⲡⲟⲩϫⲁⲓ ⲛⲧⲉϥⲯⲩⲭⲏ ⲛⲧⲟϥ ⲛⲡⲁϩⲱⲙ ⲛⲅⲉⲱⲣⲅⲓⲟⲥ ϫⲉⲕⲁⲥ ⲉϥⲉϩⲉ
ⲉⲩⲛⲁ ⲛⲛⲁϩⲣⲛ ⲡⲛⲟⲩⲧⲉ ⲡⲉⲧⲟⲩⲟⲟⲧⲃ ⲉⲟⲩⲟⲛ ⲛⲓⲙ ⲧⲁⲣⲉⲕⲣⲡϫⲟⲉⲓⲥ ⲙⲡⲏⲓ ⲉⲧⲙⲙⲁⲩ

'I am writing to you that from today and from now on until eternity, the entire house which is located in the street of the men of Pshoumare, this one which he, Pahom, son of Georgios, donated to the victorious, triumphant, crown bearing competitor, and illuminating martyr, saint Abba Biktor of the castron Jeme, for the well being of his soul, so that he shall find mercy in the presence of God who surpasses everyone, that you shall own that house, …'

(Text: W. E. Crum and G. Steindorff, German trans. W. C. Till, Engl. trans. G. Schenke)
online supplementary file 1 - Supplemental material for Oral Administration of Salmon Cartilage Proteoglycan Attenuates Osteoarthritis in a Monosodium Iodoacetate-Induced Rat Model
Creators: name: Le, Tuyen Danh
name: Vu, Hien Thi Thu
name: Iddamalgoda Arunasiri
name: Ito, Kenichi
name: Makise, Tadahiro
name: Le, Hang Thi
name: Nguyen, Truong Hong
name: Nguyen, Lai Thi Hong
name: Nguyen, An Thai
name: Pham, Binh Quoc
name: Pham, Phuong Thuy
name: Nguyen, Ha Thi Thanh
name: Phan, Minh Hong
name: Luong, Long Hoang
name: Thi, Van Anh Pham
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine

description: Supplemental material, online supplementary file 1, for Oral Administration of Salmon Cartilage Proteoglycan Attenuates Osteoarthritis in a Monosodium Iodoacetate-Induced Rat Model by Tuyen Danh Le, Hien Thi Thu Vu, Iddamalgoda Arunasiri, Kenichi Ito, Tadahiro Makise, Hang Thi Le, Truong Hong Nguyen, Lai Thi Hong Nguyen, An Thai Nguyen, Binh Quoc Pham, Phuong Thuy Pham, Ha Thi Thanh Nguyen, Minh Hong Phan, Long Hoang Luong and Van Anh Pham Thi in Natural Product Communications
Die Eigenart der Sozialpolitik in der westlichen Welt. Religiöse Entwicklungsbedingungen des modernen Wohlfahrtsstaates in vergleichender Perspektive
Creators: name: Rieger, Elmar
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2012
Subjects: Wohlfahrt; Politik; Religion; Christentum; Islam; Hinduismus; Buddhismus; Westen; China; Indien; Rationalität; Moderne; Weber; Sozialpolitik

description: Die Eigenart der Sozialpolitik in der westlichen Welt. Religiöse Entwicklungsbedingungen des modernen Wohlfahrtsstaates in vergleichender Perspektive
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 46 (2005): Europäische Wohlfahrtsstaatlichkeit. Soziokulturelle Grundlagen und religiöse Wurzeln
Supplemental Material, sj-pdf-1-ahp-10.1177_0890117120979918 - Willingness of Black and White Adults to Accept Vaccines in Development: An Exploratory Study Using National Survey Data
Creators: name: Quinn, Sandra Crouse
name: Lama, Yuki
name: Jamison, Amelia
name: Freimuth, Vicki
name: Veeraj Shah
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental Material, sj-pdf-1-ahp-10.1177_0890117120979918 for Willingness of Black and White Adults to Accept Vaccines in Development: An Exploratory Study Using National Survey Data by Sandra Crouse Quinn, Yuki Lama, Amelia Jamison, Vicki Freimuth and Veeraj Shah in American Journal of Health Promotion
ADAMTS5-specific gapmer release from an albumin biomolecular assembly and cartilage internalization triggered by ultrasound
Creators: name: Elkhashab, Marwa
name: Barreto, Goncalo
name: Fauconnier, Maxime
name: Le Bourlout, Yohann
name: Creemers, Laura B.
name: Nieminen, Heikki J.
name: Howard, Kenneth A.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Virology

description: Antisense oligonucleotides (ASOs) have reached the clinic; however, they lack tissue specificity. Albumin is a plasma-abundant macromolecule that has been shown to accumulate in inflamed tissues. In this work, we have designed a recombinant human albumin (rHA)-based biomolecular assembly incorporating a DNase-resistant phosphorothioate-based complementary oligonucleotide (cODN) and an anti-ADAMTS5 ASO for potential delivery to inflamed sites. Ultrasound (US) was used to trigger ASO release from the assembly and enhance internalization into articular cartilage. A phosphorothioate cODN was conjugated to rHA through a maleimide cross-linker after which, a therapeutic ADAMTS5-specific gapmer ASO was annealed to the cODN. ASO release was assessed after exposing the biomolecular assembly to different US conditions using an US-actuated medical needle operating at 32.2 kHz. Gene silencing efficiency of US-treated anti-ADAMTS5 ASO was assessed in human primary chondrocytes isolated from osteoarthritic patients. US-mediated ASO penetration into articular cartilage was assessed on ex vivo bovine articular cartilage. ASO release was observed after exposure to US waves in continuous mode conditions that did not compromise ASO gene silencing efficiency in human chondrocytes. Furthermore, US increased ASO internalization into bovine articular cartilage after 30 min of application without detrimental effects on chondrocyte viability. A medical needle driven by continuous US waves at 32.2 kHz has the capability of disassembling a duplex oligonucleotide and enhancing released ASOs internalization into articular cartilage. This work offers the potential delivery and the local triggered release of ASOs at the surface of articular cartilage providing potential benefits for the treatment of diverse cartilage pathologies.
E02460: Coptic sale of parts of a house, from Jeme (Upper Egypt), sold by the steward (oikonomos) of Apa *Phoibammon (soldier and martyr of Assiut, S00080), property that had previously been donated to the saint for the salvation of the donor's soul, datable to the first third of the 8th century.
Creators: name: Gschenke
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: P.KRU 18

In this document, John, the steward (oikonomos) of (the shrine of) saint Apa Phoibammon (line 63) sells parts of a house to Apa Viktor, son of Athanasios, from Jeme (lines 11–12). These are the parts of the house which a certain Georgios had in the past donated to the saint on account of the salvation of his deceased mother Ioanne (lines 19–21). The donation included moveable as well as immovable property (lines 29–32)

Lines 11–19 read as follows:

ⲉⲛⲧⲓ ⲁⲃⲟⲗ ⲛⲏⲕ ⲛⲧⲟⲕ ⲁⲡⲁ ⲃⲓⲕⲧⲱⲣ ⲡϣⲏⲣⲉ ⲛⲡⲙⲁⲕⲁⲣⲓⲟⲥ ⲁⲑⲁⲛⲁⲥⲓⲟⲥ ϩⲛ ϫⲏⲙⲉ ϩⲁ ⲡⲛⲟⲙⲟⲥ ⲛⲧⲡⲟⲗⲓⲥ
ⲛⲛⲉⲙⲉⲣⲟⲥ ⲛⲧⲁ ⲅⲉⲟⲣⲅⲓⲟⲥ ⲡϣⲏⲣⲉ ⲛⲓⲟⲩⲁⲛⲛⲉ ⲧϣⲏⲣⲉ ⲓⲩϩⲏⲗⲓⲁⲥ ⲛⲁⲡⲁ ⲃⲓⲕⲧⲱⲣ ⲧⲉⲥⲙⲁⲩ ⲧⲉ ⲉⲩⲇⲱⲝⲓⲁ ⲧⲁⲁⲩ ⲁϩⲟⲩⲛ
ⲉⲡϩⲁⲅⲓⲟⲥ ⲁⲡⲁ ⲫⲉⲃⲁⲙⲱⲛ ϩⲁ ⲡⲉⲩϫⲁⲓ ⲛⲧⲉⲩⲙⲁⲩ ⲙⲛ ⲧⲟϥ ⲉⲣⲉ ⲡⲛⲟⲩⲧⲉ ⲙⲛ ⲛⲉⲡⲣⲉⲥⲃⲓⲁ ⲛⲡⲙⲁⲣⲧⲩⲣⲟⲥ ⲛⲁⲣⲟⲩⲛⲁ
ⲛⲙⲙⲁⲩ ϩⲛ ⲡⲉϥⲃⲏⲙⲁ ϫⲉ ⲡⲙⲁ ⲉⲧⲉⲣⲭⲓⲥⲧⲓⲁⲛⲟⲥ ⲛⲓⲙ ⲣⲭⲣⲓⲁ ⲙⲙⲟϥ ⲡⲉ ⲡⲙⲁ ⲉⲧⲙⲙⲁⲩ

'We are selling you, Apa Biktor, the son of the blessed Athanasios, from Jeme, in the district of the city , the parts which George, the son of Ioanne, the daughter of Elias, son of Apa Biktor – her mother is Eudoxia –, donated to the saint Apa Phoibamon for the salvation of their mother and and his own, so that God and the intercessions of the martyr will be kind with them on his tribunal, since this is exactly the place where every Christian needs it.'

(Text: W. E. Crum and G. Steindorff, German trans. W. C. Till, Engl. trans. G. Schenke)
Wohlfahrtspolitik in Schweden. Die kulturellen Grundlagen des ›Volksheims‹ im Wandel
Creators: name: Jochem, Sven
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2012
Subjects: Wohlfahrt; Politik; Schweden; Sozialdemokratie; Privatisierung; Deregulierung; Wert; Europa; Neoliberalismus

description: Wohlfahrtspolitik in Schweden. Die kulturellen Grundlagen des ›Volksheims‹ im Wandel
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 46 (2005): Europäische Wohlfahrtsstaatlichkeit. Soziokulturelle Grundlagen und religiöse Wurzeln
E02461: Coptic sale of a house as inheritance, from Jeme (Upper Egypt), a property purchased from the monastery of *Phoibammon (soldier and martyr of Assiut, S00080), datable to the middle of the 8th century, possibly dated 5 November 747.
Creators: name: Gschenke
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: P.KRU 19

In this document, a father is handing down a house jointly to his two children, after their mother's death. The house is said to have been purchased within saint Phoibammon, which might refer to an area or a district, but could also suggest a house sold by representatives of the saint's shrine, as is the case in E02458, $Eß2459 and E02460.

Lines 24–30 read as follows:

ⲧⲉⲛⲟⲩ ⲇⲉ ⲧⲓϩⲟⲙⲟⲗⲟⲅⲉⲓ ⲁⲛⲟⲕ ϩⲗⲗⲱ ⲡⲉⲛⲧⲁϥϣⲣⲡⲥϩⲁⲓ ⲛⲏⲧⲛ ⲛⲧⲱⲧⲛ ⲛⲁⲙⲉⲣⲁⲧⲉ ⲛϣⲏⲣⲉ ⲙⲏⲛⲁ ⲙⲛ ⲧⲥⲱⲛⲉ ⲙⲡⲏⲓ ⲧⲏⲣϥ
ⲛⲧⲁϥϣⲟⲡϥ ⲙⲛ ⲧⲉⲧⲛⲙⲁⲁⲩ ⲛϩⲟⲩⲛ ⲡϩⲁⲅⲓⲟⲥ ⲫⲟⲓⲃⲁⲙⲱⲛ

'And now I, the aforementioned Hello, I agree (to give) to you, my beloved children Mena and Tsone, the entire house which I (lit. he) purchased together with your mother from within saint Phoibammon'

Lines 103–105 of the verso read:

ⲡⲏⲓ ⲛⲧⲁⲓϣⲟⲡϥ ⲙⲛ ⲧⲉⲧⲛⲙⲁⲁⲩ ϩⲓ ⲡϩⲁⲅⲓⲟ(ⲥ) ⲁⲡⲁ ⲫⲟⲓⲃ(ⲁⲙⲱⲛ)

'… the house which I purchased together with your mother from saint Apa Phoibamon.'

(Text: W. E. Crum and G. Steindorff, German trans. W. C. Till, Engl. trans. G. Schenke)
Eine ›paternalistisch-marktwirtschaftliche Hybride‹? Vom Schutz zur Aktivierung – Die Reformen des Sozialstaates in Polen
Creators: name: Fel, Stanisław
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2012
Subjects: Politik; Sozialstaat; Polen; Marktwirtschaft; Transformation; Europa; Solidarität; Verantwortung; Reform

description: Eine ›paternalistisch-marktwirtschaftliche Hybride‹? Vom Schutz zur Aktivierung – Die Reformen des Sozialstaates in Polen
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 46 (2005): Europäische Wohlfahrtsstaatlichkeit. Soziokulturelle Grundlagen und religiöse Wurzeln
Additional file 4 of Up-to-date quality survey and evaluation of neonatal screening programs in China
Creators: name: Zhang, Jinming
name: Jin, Lizi
name: Feng, Penghui
name: Fei, Yu
name: Li, Wen
name: Jiang, Ting
name: Zhang, Zehao
name: He, Falin
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Cell Biology
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Science Policy

description: Supplementary Material 4
Globalisierung. Ein Bericht vom ›Berliner Werkstattgespräch‹ der SozialethikerInnen 2004
Creators: name: Vogt, Markus
name: Kruip, Gerhard
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2012

description: Globalisierung. Ein Bericht vom ›Berliner Werkstattgespräch‹ der SozialethikerInnen 2004
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 46 (2005): Europäische Wohlfahrtsstaatlichkeit. Soziokulturelle Grundlagen und religiöse Wurzeln
Peptides rapidly transport antibiotic across the intact tympanic membrane to treat a middle ear infection
Creators: name: Kurabi, Arwa
name: Sereno, Emily
name: Ryan, Allen F.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: The tympanic membrane (TM) forms an impenetrable barrier to medical therapies for middle ear (ME) diseases like otitis media. By screening a phage-displayed peptide library, we have previously discovered rare peptides that mediate the active transport of cargo across the intact membrane of animals and humans. Since the M13 filamentous bacteriophage on which the peptides are expressed are large (nearly 1 µm in length), this offers the possibility of noninvasively delivering drugs, large drug packages, or gene therapy to the ME. To evaluate this possibility, EDC chemistry was employed to covalently attach amoxicillin, or neomycin molecules to phage bearing a trans-TM peptide, as a model for large drug packages. Eight hours after application of antibiotic-phage to the TM of infected rats, ME bacterial titers were substantially reduced compared to untreated animals. As a control, antibiotic was linked to wild-type phage, not bearing any peptide, and application to the TM did not affect ME bacteria. The results support the ability of rare peptides to actively deliver pharmacologically relevant amounts of drugs through the intact TM and into the ME. Moreover, since bacteriophage engineered to express peptides are viral vectors, the trans-TM peptides could also transport other viral vectors into the ME.
Vorwort
Creators: name: Heimbach-Steins, Marianne
name: Filipović, Alexander Alexander
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2012
Subjects: Lebenslauf, Generationen, Sozialethik, christliche Sozialethik, Sozialpolitik, Familie, Familienpolitik

description: Mit dem Thema »Sozialethik für eine Gesellschaft des langen Lebens« rücken wir in diesem Jahrbuch nicht ein sozialpolitisches Handlungsfeld wie Arbeit (JCSW 52, 2011) oder Gesundheit (JCSW 47, 2006), sondern die Biographie – den individuellen Lebenslauf sowie die kohorten- und generationentypischen Lebensverlaufsmuster – als strukturierendes Moment politischen und gesellschaftlichen Handelns in den Mittelpunkt des sozialethischen Interesses. In dem Stichwort Lebenslaufpolitik werden sowohl die Ebene politischer und gesellschaftlicher Praxis als auch die Ebenen sozialwissenschaftlicher Analyse und sozialethischer Reflexion aufgerufen. Im Unterschied zu den geläufigen – und nicht selten angstbesetzten – Debatten um den demographischen Wandel und um die alternde Gesellschaft – zielt Lebenslaufpolitik auf die aktive Gestaltung einer Gesellschaft des langen Lebens und, dies wird die genuin sozialethische Aneignung der Lebenslaufperspektive herausarbeiten, auf Befähigung der Menschen zur verantwortlichen Führung ihres – im Durchschnitt der Bevölkerung – immer längeren Lebens in einem komplexer werdenden Generationengefüge.
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 53 (2012): Sozialethik für eine Gesellschaft des langen Lebens
Orchestrating T and NK cells for tumor immunotherapy via NKG2A-targeted delivery of a de novo designed IL-2Rβγ agonist
Creators: name: Chen, Jie
name: Ren, Enhui
name: Tao, Ze
name: Lu, Hongyu
name: Huang, Yunchuan
name: Li, Jing
name: Chen, Yuzhe
name: Chen, Zhuo
name: She, Tianshan
name: Yang, Hao
name: Zhu, Hong
name: Lu, Xiaofeng
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: As T and NK cell exhaustion is attributed to increased expression of immune checkpoints and decreased production of proliferative cytokines by these cells, immune checkpoint-targeted delivery of proliferative cytokines might induce robust and sustained antitumor immune responses. Here, the expression profile of NKG2A was first found to be narrower than that of PD-1 in tumor-infiltrated immune cells. Moreover, unlike PD-1, NKG2A was predominantly co-expressed with IL-2Rβγ in tumor-infiltrated CD8+ T and NK cells, but not in Tregs, suggesting that NKG2A might be an ideal target for delivery of IL-2Rβγ agonists to overcome T and NK exhausting. For NKG2A-targeted delivery of an IL-2Rβγ agonist, a single molecule of de novo designed N215 endowed with Immunoglobin G(IgG)-binding ability was coupled to an antibody against NKG2A (αNKG2A) to produce αNKG2A-N215. NKG2A- and IL-2Rβγ-binding were well preserved in αNKG2A-N215, allowing αNKG2A-N215 to act as both an immune checkpoint inhibitor and a T and NK cell stimulator. Intravenously injected αNKG2A-N215 predominantly induced expansion of tumor-infiltrated CD8+ T and NK cells while showing little stimulation of Tregs. Compared with the separate combination using αNKG2A and N215, αNKG2A-N215 exerted a greater antitumor effect in mice bearing MC38 or B16/F1 tumors. 50% of mice bearing MC38 tumors were cured by αNKG2A-N215, and long-term immunological memory against the tumor was induced in these mice. These results indicate that NKG2A is another ideal target for delivery of an IL-2Rβγ agonist, and αNKG2A-N215, with specificities for both NKG2A and IL-2Rβγ, might be developed as a novel agent for immunotherapy.
Lebenslaufpolitik – Anforderungen an Generationen- und Geschlechtergerechtigkeit in einer Gesellschaft des langen Lebens
Creators: name: Welskop-Deffaa, Eva M.
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2012
Subjects: Politik, Familienpolitik

description: Zusammenfassung
Menschen leben heute durchschnittlich 30 Jahre länger als vor 100 Jahren. Gleichzeitig ist dieses längere Leben von vervielfältigten Entscheidungsnotwendigkeiten unter den Vorzeichen medialer Beschleunigung geprägt. Orientierung bietet in der Gesellschaft des langen Lebens die Zugehörigkeit zu einer Generation. Gemeinsame Generationenerfahrungen verweisen auf objektive Ähnlichkeiten, die Politik zum Ausgangspunkt passgenauer Konzepte nehmen sollte. Lebenslaufpolitik – stimmige Politik in einer Gesellschaft des langen Lebens – muss allerdings auch der Geschlechtergerechtigkeit herausgehobene Aufmerksamkeit schenken. Eine zentrale Erwartung der Menschen an den institutionellen Rahmen besteht darin, dass die mit gemeinsam getroffenen Entscheidungen (linked lives) verbundenen Chancen und Risiken nicht strukturell geschlechtshierarchisch ungleich verteilt sind. Anhand aktueller Rentenreformdebatten macht der Beitrag abschließend deutlich, welchen Anforderungen aktive Lebenslaufpolitik konkret genügen muss.

Abstract
On average, people today live 30 years longer than a hundred years ago. At the same time, this extended life is marked by the new media and the resulting acceleration of processes and multiplied needs for decision. One anchor for orientation in a long-life society is the sense of belonging to a generation. Shared experiences refer to objective similarities, on which politics should base the development of apposite concepts. Life-course politics – inherently consistent politics in a long-life society – must of course also pay particular attention to gender equity. One of the citizens’ central expectations of the institutional framework is that the opportunities and risks involved in decisions taken together (linked lives) are not distributed unequally with regard to gender. Using the example of the ongoing debates on pension reform, this paper concludes by underlining the requirements active life-course politics has to meet.
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 53 (2012): Sozialethik für eine Gesellschaft des langen Lebens
Wandel von Generationenverhältnissen –  sozialpolitische Herausforderungen der Generationengerechtigkeit
Creators: name: Laux, Bernhard
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2012
Subjects: Sozialpolitik; Politik; theologische Ethik; Gerechtigkeit; Generationengerechtigkeit; Familie; Kinder; Eltern

description: Zusammenfassung
Der Beitrag betrachtet die Entwicklung des Generationenverhältnisses unter der normativen Perspektive der Gerechtigkeit und Solidarität zwischen den Generationen. Der Fokus liegt auf sozialpolitischen Fragestellungen. Der Autor bezieht sich kritisch auf die in der Öffentlichkeit vertretene These zunehmender Konflikte zwischen den Generationen und einer Benachteiligung der Jüngeren durch die Älteren. Die Generationenbeziehungen in den Familien sind durch eine positive Entwicklung und ein hohes Solidaritätsniveau gekennzeichnet. Die sozialen Sicherungssysteme werden durch die demographische Entwicklung zwar belastet, jedoch sind die Herausforderungen lösbar. Scheinbare Verletzungen der Gerechtigkeit zwischen den Generationen im sozialpolitischen Kontext erweisen sich bei genauerer Analyse als intragenerationelle Gerechtigkeitsprobleme zwischen Familien und Kinderlosen sowie zwischen Arm und Reich. Der Autor sieht allerdings die Gefahr, dass das Schlagwort »Generationengerechtigkeit« zum Abbau sozialstaatlicher Solidarität missbraucht werden könnte. Erforderlich wäre aber mehr Engagement insbesondere zugunsten der jungen Generation und ihrer Familien. Eine lebenslaufsensible Politik ist aus der Perspektive der Generationenbeziehungen wichtig; dennoch scheint das Konzept der Lebenslaufpolitik für die Gefahr neuer sozial- und familienpolitischer Normalitätsdefinitionen anfällig zu sein.

Abstract
Focussing on socio-political issues, this paper looks at the development of generation relations from the normative perspective of justice and solidarity between generations. The author critically examines the publicly championed thesis of increasing conflicts between the generations and of the old placing the young at a disadvantage. However, generation relations in families are marked by a positive development and a high level of solidarity. While it is true that the demographic development puts a strain on the social security systems, these challenges can be met. Ostensible socio-political violations of cross-generation justice prove on closer inspection to be intra-generational justice issues between families and the childless and between rich and poor. The author however fears that the catchphrase »generation justice« could be misused to justify further cuts in social services. What is needed, on the contrary, is more commitment, particularly for the benefit of the young generation and their families. From the perspective of generation relations, politics which is sensitive to the course of life is material; the concept of life-course politics, however, seems to be vulnerable to socio- and family political definitions of normality.
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 53 (2012): Sozialethik für eine Gesellschaft des langen Lebens
Additional file 1 of Gastrointestinal microbiome of ARDS patients induces neuroinflammation and cognitive impairment in mice
Creators: name: Zheng, Hong
name: Zhao, Qihui
name: Chen, Jianuo
name: Lu, Jiahui
name: Li, Yuping
name: Gao, Hongchang
Publisher: name: figshare
Year: 2024
Subjects: subject: Cell Biology
subject: Neuroscience
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health
subject: Hematology

description: Additional file 1: Table S1. Primer pairs used in this study. Table S2. Clinical characteristics of participants. Table S3. The number of significantly altered gut microbes between ARDS/CAP patients and normal controls. Figure S1. The gut microbiota from ARDS/CAP patients leads to lung inflammation in mice. Figure S2. The gut microbiota from ARDS/CAP patients causes astrocyte proliferation and neuron loss in the brain of mice.
Inhaltsverzeichnis
Creators: name: Heimbach-Steins, Marianne
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2012

description: Inhaltsverzeichnis
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 53 (2012): Sozialethik für eine Gesellschaft des langen Lebens
Machine learning-assisted design of immunomodulatory lipid nanoparticles for delivery of mRNA to repolarize hyperactivated microglia
Creators: name: Rafiei, Mehrnoosh
name: Shojaei, Akbar
name: Chau, Ying
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Regulating inflammatory microglia presents a promising strategy for treating neurodegenerative and autoimmune disorders, yet effective therapeutic agents delivery to these cells remains a challenge. This study investigates modified lipid nanoparticles (LNP) for mRNA delivery to hyperactivated microglia, particularly those with pro-inflammatory characteristics, utilizing supervised machine learning (ML) classifiers. We developed and screened a library of 216 LNP formulations with varying lipid compositions, N/P ratios, and hyaluronic acid (HA) modifications. The transfection efficiency of eGFP mRNA was assessed in the BV-2 murine microglia cell line under different immunological states, including resting and activated conditions (LPS-activated and IL4/IL13-activated). ML-guided morphometric analysis tracked the phenotypes of various microglia subtypes before and after transfection. Four supervised ML classifiers were investigated to predict transfection efficiency and phenotypic changes based on LNP design parameters. The Multi-Layer Perceptron (MLP) neural network emerged as the best-performing model, achieving weighted F1-scores ≥0.8. While it accurately predicted responses from LPS-activated and resting cells, it struggled with IL4/IL13-activated cells. The MLP model was validated by predicting the performance of four unseen LNP formulations delivering eGFP mRNA to LPS-activated BV2 cells. HA-LNP2 emerged as optimal formulation for delivering target IL10 mRNA, effectively suppressing inflammatory phenotypes, evidenced by shifts in cell morphology, increased IL10 expression, and reduced TNF-α levels. We also evaluated HA-LNP2 on LPS-activated human iPSC-derived microglia, confirming its efficacy in modulating inflammatory responses. This study highlights the potential of tailored LNP design and ML techniques to enhance mRNA therapy for neuroinflammatory disorders by leveraging carrier’s immunogenic properties to modulate microglial responses.
Additional file 1 of A role for the ATP-dependent DNA ligase lig E of Neisseria gonorrhoeae in biofilm formation
Creators: name: Pan, Jolyn
name: Singh, Avi
name: Hanning, Kyrin
name: Hicks, Joanna
name: Williamson, Adele
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 1
E02463: Coptic agreement on sharing inherited property, from Jeme (Upper Egypt), mentioning a neighbourhood of Apa *Ananias, the bishop (S01224), dated 29 June 748 or 763.
Creators: name: Gschenke
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: P.KRU 24

In this document two half-sisters agree over the terms on how to share a house they jointly inherited from their common grandmother. The property in question is located in Jeme, in the area of saint Ananias.

Lines 65–68 read as follows:

ⲡⲏⲓ ⲧⲏⲣϥ ⲙⲛ ⲡⲁⲛϩ ⲉⲧⲙⲙⲁⲁⲩ ⲉⲩⲕⲏ ⲉϩⲣⲁⲓ ϩⲙ ⲡⲓⲕⲁⲥⲧⲣⲟⲛ ⲛϫⲏⲙⲉ ϩⲓ ⲧⲣⲏⲩⲉ ⲙⲡⲉⲧⲣⲟⲩⲟⲉⲓⲛ ⲉⲃⲟⲗ ϩⲛ ⲛⲉⲧⲟⲩⲁⲁⲃ ⲡϩⲁⲅⲓⲟⲥ ⲁⲡⲁ ⲛⲁⲛⲓⲁⲥ ⲡⲉⲡⲓⲥⲕ(ⲟⲡⲟⲥ)

'The entire house and that yard are located in the castron Jeme, in the neighbourhood of the one who shines forth from among the saints, the saint Apa Ananias, the bishop.'

(Text: W. E. Crum and G. Steindorff, German trans. W. C. Till, Engl. trans. G. Schenke)
Evaluating nurse preferences for a novel on-body delivery system vs. manual syringes for large-volume subcutaneous drug administration: a survey study
Creators: name: Desai, Mehul
name: Faiman, Beth
name: Gorski, Lisa A.
name: Miles, Ashley
name: Sterlin, Valentina
name: Curry, Nicole
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Space Science
Medicine
Cell Biology
Pharmacology
Biological Sciences not elsewhere classified

description: While nurses report challenges with the manual administration of large-volume subcutaneous drugs, these challenges and potential solutions are not captured in the literature. In this cross-sectional study, 45 nurses with experience administering large-volume subcutaneous biologics completed an 18-item survey about preferences for syringes vs. on-body delivery systems. 100% responded that an on-body delivery system seemed easy to learn and use and preferable to syringes. In a drug delivery scenario including comprehensive administration details and assuming equivalent safety and efficacy, 97.78% preferred the on-body delivery system to a daratumumab/hyaluronidase syringe. In the total sample, this preference was primarily attributed to (1) reduced nurse effort due to hands-free delivery, (2) decreased patient pain due to a thinner needle, (3) elimination of needlestick injuries due to a hidden needle, and (4) increased clinic efficiency due to hands-free delivery. 95.56% felt that the on-body delivery system would improve clinic throughput better than syringes. Nurses reported that an on-body delivery system would be easy to learn and use and would improve clinic efficiency and safety. They underscored the importance of decreasing nurse physical burden, needlestick injuries, and patient needle phobia. Contrary to the assumption that speed is paramount, nurses prioritized reducing effort, enhancing administration safety, and improving patient comfort over injection speed.
E02462: Coptic sale of half a house, from Jeme (Upper Egypt), a property located outside of (the area of) the great bishop Apa *Patermouthios (possibly S01222); dated 12 June 725.
Creators: name: Gschenke
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: P.KRU 21

In this document, a man named Pesynthios, son of Paul, from Jeme, acknowledges the sale of half a house to two brothers, Hemai and the presbyter Senoutios, son of Germanos, likewise from Jeme. The location of the property is given as being outside of the bishop saint Apa Patermouthios from Jeme, which borders it on the west.

Lines 31–33 and Lines 36–38 read as follows:

ⲉⲓⲧⲓ ⲛⲁⲕ ⲛⲧⲟⲕ ⲏⲙⲁⲓⲁ ⲙⲛ ⲥⲉⲛⲟⲩⲑⲓⲟⲥ ⲡⲣⲉⲥⲃⲩⲧⲉⲣⲟⲥ ⲛϣⲏⲣⲉ ⲛⲡⲙⲁⲕⲁⲣⲓⲟⲥ ⲅⲉⲣⲙⲁⲛⲟⲥ ⲛⲣⲙⲡⲕⲁⲥⲧⲣⲟⲛ ϫⲏⲙⲉ ...
ⲛⲧⲡⲏϣⲉ ⲙⲡⲁⲏⲓ ⲧⲏⲣϥ ⲉϥⲕⲏ ⲉϩⲣⲁⲓ ϩⲓⲃⲁⲗ ⲛⲡⲛⲟϭ ⲛⲉⲡⲓⲥⲕⲟⲡⲟⲥ ⲡϩⲁⲅⲓⲟⲥ ⲁⲡⲁ ⲡⲁⲧⲉⲣⲙⲟⲩⲑⲓⲟⲥ ⲙⲡⲕⲁⲥⲧⲣⲟⲛ ϫⲏⲙⲉ

'… I am giving you, Hemai and Senoutios, the presbyter, the sons of the blessed Germanos, inhabitants of the castron Jeme, … the half of my whole house which is located outside the great bishop, saint Apa Patermouthios in the castron Jeme.'

Line 40 reads:

ⲡⲉⲙⲛⲧ ⲫⲁⲅⲓⲟⲥ ⲁⲡⲁ ⲡⲁⲧⲉⲣⲙⲟⲩⲑ(ⲓⲟⲥ)

'West: saint Apa Patermouth(ios).'

(Text: W. E. Crum and G. Steindorff, German trans. W. C. Till, Engl. trans. G. Schenke)
Advanced hydrogel material for colorectal cancer treatment
Creators: name: Guo, Yu
name: Wang, Min
name: Zhang, Yuzhong
name: Zhao, Zeyun
name: Li, Jiannan
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Colorectal cancer is one of the most common cancers worldwide, and its incidence rates are increasing every year. Treatments for CRC include surgical resection, chemotherapy, radiotherapy, targeted therapy, and immunotherapy. Although various agents have been used in the treatment of malignant tumors, they are not as effective as expected. This is primarily owing to the lack of selectivity, poor solubility, and severe side effects of most agents. It is necessary to develop more efficient drug delivery systems for the precise targeting of the tumor site and effective therapeutic effects to meet clinical needs. A hydrogel is a three-dimensional network material composed of crosslinked side chains of hydrophilic or hydrophobic groups and a polymer backbone. Hydrogels possess useful properties including high water content, adjustable physical characteristics, elasticity, flexibility, reversible swelling, and multifunctionality. These properties render them ideal biomaterials with a broad range of applications in biomedicine and bioengineering. In this review, we introduce the pathophysiology and current therapeutic advances in CRC and summarize the applications of hydrogels composed of different materials as well as smart response hydrogels as drug carriers in CRC treatment. We also analyze the unique advantages and challenges of using hydrogels as targeted drug delivery carriers in tumor therapy.