cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Les préférences de l'état sur les projets macroéconomiques touchant les relations canado-américaines.
Creators: name: Michaud, Denis.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Political Science, International Law and Relations.

description: Lorsque de larges discussions sont lancées sur des questions comme la création d'une zone de libre-échange, d'une union monétaire ou d'une union douanière, quel type d'interactions peut-on observer dans les espaces national et bilatéral? Cette thèse étudie des projets macroéconomiques impliquant plus d'un État en s'intéressant tout particulièrement au comportement des élites politiques et économiques. Durant les dernières décennies, des débats sur l'intégration continentale ont eu lieu dans l'espace national canadien. Nous souhaitons mieux comprendre le niveau d'autonomie obtenu par les gouvernants canadiens lorsque des groupes de la société civile ont lancé des propositions visant à changer, sur des bases structurelles, la relation commerciale ou monétaire entre le Canada et les États-Unis. Comment les gouvernants ont-ils réagi, quel type de prise de position ont-ils présenté et quel niveau de contrôle ont-ils obtenu sur les débats et l'élaboration des politiques publiques? Quelle aura été l'emprise des gouvernants sur l'évolution des positions et les principaux déplacements? À cette problématique s'ajoute le fait que le Canada est généralement vu comme étant dans une relation de pouvoir asymétrique avec les États-Unis, le second État impliqué dans les cas étudiés. Nous montrons dans cette thèse qu'un élément central de l'analyse doit être les interactions entre les gouvernants des deux pays alors que des projets sont discutés dans les espaces nationaux respectifs. En nous intéressant aux déclarations publiques des gouvernants, nous cherchons à mieux comprendre les tactiques et stratégies mises en oeuvre par ceux qui, dans la promotion de certains projets, doivent s'assurer qu'ils pourront obtenir les appuis d'un nombre de groupes d'intérêt suffisamment grand, mais aussi que les gouvernants du second État arrivent aussi à obtenir une victoire politique sur leur version de ce même projet. Nous soutenons qu'alors que les élites politiques et économiques canadiennes doivent réagir aux grandes orientations fixées par les gouvernants américains, ces derniers arrivent mal, dans la préparation de leurs politiques macroéconomiques, à s'arrêter à des projets qui porteraient spécifiquement sur le Canada. Nous cherchons à voir comment cette situation peut influencer les tactiques et stratégies utilisées par les gouvernants canadiens. Cette thèse porte sur l'intégration économique, sur les relations canado-américaines et sur le niveau d'autonomie de l'État dans l'espace national. De plus, nous apportons une réflexion sur le concept d'État et sur les processus d'élaboration des politiques publiques au Canada. Les postulats retenus sont principalement ceux de l'approche centrée sur la sphère étatique.
Louis A. Bertrand’s Voyage from Icarianism to Mormonism: French Romantic Socialism and Mormon Communalism in the Nineteenth Century
Creators: name: Freeman, Erik
Publisher: name: Brandeis University
Year: 2013
Subjects: Mormonism
Communalism
Socialism
Nineteenth Century
France

description: In 1851, a prominent French Romantic Socialist journalist, Louis A. Bertrand, converted to the Church of Jesus Christ of Latter Day Saints (Mormonism) in Paris. His conversion from French Icarianism--a form of Romantic Socialism--to Mormonism did not modify his previous religious or social beliefs. In fact, he considered Mormonism as the ideal version of a Romantic Socialist sect. This thesis looks at similarities and differences between Romantic Socialism and Mormonism throughout the mid-nineteenth century focusing specifically on Bertrand’s story. Furthermore, writings by other Romantic Socialists and Mormons on issues of community, religion, economics and revolution reaffirmed that Mormons paralleled these French socialists. Ultimately, Bertrand’s story among Romantic Socialists in France and Mormons in America, suggests that American Mormonism throughout the nineteenth century should be viewed as part of an international socio-religious movement that includes Romantic Socialism.
The impact of tariff liberalisation on Canadian employment, 1987-1996: An empirical investigation of selected manufacturing industries.
Creators: name: Hosein, Judy.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Economics, Labor.

description: This paper examines the impact of tariff liberalisation on employment for selected Canadian manufacturing industries between 1987--1996. An input-output model was constructed to estimate the changes in the level of employment arising from changes in the flow of imports and exports due to tariff liberalisation. In addition to an input-output model, preliminary econometric testing was also conducted to capture the effects of other structural and cyclical factors that may have also affected employment during the same period. In this regard, an OLS model was constructed that examined the relationship between employment and the following variables: exchange rates, Canadian gross domestic product, US gross domestic product, and tariff rates. The main finding of the study was that tariff liberalisation had a minimal impact on employment, but that the extent of the impact varied across industries. Moreover, the employment effects were found to be dependent on the specific production requirements of industries rather than trade sensitivity, as is commonly argued in the economic literature. It was also established that, in conjuction with tariff liberalisation, other macro-economic factors also affected the level of employment during the same period.
Subcloning, Enzymatic Characterization, and in silico Docking of Transglutaminase 2
Creators: name: Fisher, Oriana
Publisher: name: Brandeis University
Year: 2009
Subjects: docking experiment
TGaseII
Tissue transglutaminase
Inhibitors

description: Tissue transglutaminase (TGaseII) is an enzyme that is implicated in a wide range of diseases, and catalyzes the formation of γ-glutamyl-ε-lysine crosslinks. While other related enzymes have been extensively characterized, much remains unknown about TGaseII. Our goal is to find inhibitors of TGaseII using a guided approach. In order to do this, three separate constructs of the human form of the enzyme were expressed and purified in E. coli with the intention of co-crystallizing the enzyme bound to an inhibitor and solving its structure. Additionally, the results of two previous structural studies of the human form of the enzyme were used for in silico docking to identify small molecules with which it might interact, as well as to help determine how two known inhibitors interact with TGaseII. The three constructs studied had drastically different levels of enzymatic activity and degrees of purity. This seems to further elucidate the structural mechanisms of the enzyme. The docking experiments identified a loop region of the protein with which several ligands and inhibitors associated. The compounds identified in the docking experiments will be evaluated in a cell-based assay in Dr. Rajiv Ratan’s lab at Cornell University.
Volatiles composition and antioxidant activity Inula oculus-christi L. from Serbia
Creators: name: Mitić, Violeta D.
name: Ilić, Marija D.
name: Jovanović, Vesna P. Stankov
name: Djordjevic, Aleksandra S.
name: Marković, Marija S.
name: Stojanović, Gordana S.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: The chemical composition of the essential oil and the volatiles obtained by static headspace (HS) of Inula oculus-christi L. is presented. The GC-MS analysis of the hydrodistilled oil resulted in the identification of 90 components, representing 92.7% of the oil. The most abundant compounds were: caryophyllene oxide (9.8%), trans-longipinocarveol (9.2%), eucalyptol (7.3%) and intermedeol (6.2%). The major constituent of I. oculus-christi L. HS volatiles was eucalyptol (87.4%). The antioxidant activity was evaluated by four different methods: 2,2-diphenyl-1-picryl-hydrazylhydrate free radical assay (DPPH), 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) method, total reducing power (TRP), ferric reducing antioxidant power (FRAP), and cupric reducing antioxidant capacity (CUPRAC). Total phenolic content in (TPC) examined oil was 177.95 µg GAE/mg oil. Radical scavenging potential of the oil was promising RSC-DPPH was 57.4% and RSC-ABTS was 82.7%.
Bioactive compounds and antioxidant capacity of Chuquiraga jussieui J.F.Gmel from the highlands of Ecuador
Creators: name: Bonilla, Daniel A. Guerrero
name: Granda-Albuja, María G.
name: Guevara, Mabel
name: Iturralde, Gabriel A.
name: Jaramillo-Vivanco, Tatiana
name: Giampieri, Francesca
name: Alvarez-Suarez, José M.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Hematology

description: Chuquiraga jussieui J.F.Gmel is grown between 3000 and 5000 meters above sea level throughout the Andean region of Ecuador and used by the indigenous populations of the Andes for medicinal purposes. Here, we determined the total phenolic, flavonoids, vitamin C and carotenoids content of the leaves and flowers of Ch. jussieui J.F.Gmel from different highlands of Ecuador as well as the capacity of a crude methanolic extract from the both parts of the plant to scavenge free radicals and protect red blood cell membranes from lipid oxidation. The leaves showed a high bioactive compound content in comparison to the flowers. The crude extract from the leaves proved to be more effective than the flowers in reducing iron and scavenging the DPPH, O2− and H2O2 radicals, as well as in protecting cellular membrane against lipid oxidation, demonstrating that Ch. jussieui J.F.Gmel represents an important source of bioactive compounds with relevant healthy properties.
Metabolomic profiling and anti-infective potential of Zinnia elegans and Gazania rigens (Family Asteraceae)
Creators: name: Alshymaa Abdel-Rahman Gomaa
name: Samy, Mamdouh Nabil
name: Abdelmohsen, Usama Ramadan
name: Krischke, Markus
name: Mueller, Martin J.
name: Wanas, Amira Samir
name: Desoukey, Samar Yehia
name: Kamel, Mohamed Salah
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The present study evaluates the chemical composition of Zinnia elegans and Gazania rigens based on their metabolomic profiles using liquid chromatography coupled with high-resolution mass spectrometry (LC‐HR-MS), alongside with the anti-infective activities of their ethanol extracts, as well as, different fractions. A significant difference was observed between the LC-MS profiles of the two plants such as, coumarins, sesquiterpene lactones and phenylethanoids which were characteristic for Z. elegans, while amides and phenolic acid derivatives were characteristic for G. rigens. These results highlight the chemical potential of Z. elegans and G. rigens. Furthermore, the ethyl acetate fraction of Z. elegans showed a significant antimalarial activity with IC50 values of 21.03 and 13.72 µg/mL against Plasmodium falciparum D6 and P. falciparum W2, respectively.
Development and characterization of dense membranes for gas separation made from high molecular weight sulfonated poly (phenylene oxide): Effect of casting conditions on the morphology and performance of the membranes.
Creators: name: Kruczek, Boguslaw.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Engineering, Chemical.

description: Membrane gas separation emerged as an alternative gas separation technology 20 years ago. In comparison with traditional gas separation technologies, membranes offer a number of advantages, including low capital and operational costs along with simplicity and flexibility of operation. On the other hand, membranes cannot compete on the basis of product purity. Improvements in this area require development and characterization of new membrane materials with better gas separation properties compared to the existing polymers. This research was focused on the improvement of gas transport properties of poly(2,6-dimethyl-1,4-phenylene oxide) (PPO) by chemical and physical modifications of the polymer. The study was divided into two parts: (1) chemical modifications of PPO along with characterization of the products; (2) investigation of the effect of casting conditions. High molecular weight PPO was sulfonated to different ion exchange capacity (IEC) values with chlorosulfonic acid. The resulting polymer, sulfonated PPO in the acid form (HSPPO), was further modified by substituting the proton in sulfonic groups by various metal cations including Na +, Mg2+, and Al3+. Some physical properties such as density, thermal stability, and x-ray diffraction as well as the gas transport properties of the membranes were determined. Substitution of the proton in sulfonic groups by metal cations increases polarity and density of the polymer. In some instances, a small increase in d-spacing and X-ray diffraction is also observed. Introduction of metal cation into the polymer backbone improves its thermal stability. Despite a greater density, MeSPPO is more permeable to gases compared to the corresponding HSPPO. To investigate the effect of casting conditions dense membranes were prepared using different solvents in casting solution. In addition two series of dense membranes were prepared in which solution temperature and the film casting temperature were controlled separately. The change of solvent in casting solution results in changes of more than two-fold in gas permeability and changes of up to 12% in permeability ratio of the membrane. The changes in gas transport properties are associated with significant changes in the surface morphology of the membrane. This study has also revealed some interesting relationship between the testing system and the obtained gas transport data. In particular, membranes tested in a system in which permeate side is open to atmosphere are influenced by relative humidity in the atmosphere. An increase in relative humidity in the atmosphere increases the apparent CO2 permeability and CO 2/CH4 permeability ratio and decreases the apparent O 2 permeability and O2/N2 permeability ratio. (Abstract shortened by UMI.)
Pseudochoutagus Che, Zhang & Wang 2011
Creators: name: Constant, Jérôme
name: Pham, Hong Thai
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Issidae
Pseudochoutagus

description: Genus Pseudochoutagus Che, Zhang & Wang, 2011
Pseudochoutagus Che, Zhang & Wang, 2011: 63.
Type species: Pseudochoutagus curvativus Che, Zhang & Wang, 2011, by original designation.
Diagnosis
The genus Pseudochoutagus can be differentiated from all other genera of Parahiraciina by the following combination of characters (Che et al. 2011; Constant 2021):
(1) head prolongated anteriorly by an elongate, straight, acutely pointed cephalic process;
(2) vertex and distal half of frons with moderate median carina;
(3) sides of body rounded;
(4) metatibiae with seven apical spines;
(5) anal tube of male spatulate and with apical margin weakly emarginate;
(6) aedeagus with pair of long asymmetrical, basiventral processes projecting cephalad then reflexed and distally sinuate;
(7) pygofer subrectangular in lateral view, without posterior process.
Note
The genus was described by Che et al. (2011) to include a species from Hainan Island in China. An additional species was described shortly after from North Vietnam (Gnezdilov & Constant 2012). The two new species described hereafter greatly extend the distribution of the genus to the south.
Species included (distribution)
Pseudochoutagus curvativus Che, Zhang & Wang, 2011 (China (Hainan) – Che et al. 2011) Pseudochoutagus lindae sp. nov.
Pseudochoutagus rubens Gnezdilov & Constant, 2012 (Vietnam – Gnezdilov & Constant 2012) Pseudochoutagus trungi sp. nov.
description: Published as part of Constant, Jérôme & Pham, Hong Thai, 2024, Issid planthoppers from Bach Ma and Phong Dien in Central Vietnam. I. Tribe Parahiraciini (Hemiptera: Fulgoromorpha: Issidae), pp. 1-64 in European Journal of Taxonomy 975 on page 42, DOI: 10.5852/ejt.2024.975.2769, http://zenodo.org/record/14508730
A pharmacogenetic signature of high response to Copaxone in late-phase clinical-trial cohorts of multiple sclerosis
Creators: name: Ross, Colin J.
name: Towfic, Fadi
name: Shankar, Jyoti
name: Laifenfeld, Daphna
name: Thoma, Mathis
name: Davis, Matthew
name: Weiner, Brian
name: Kusko, Rebecca
name: Zeskind, Ben
name: Knappertz, Volker
name: Grossman, Iris
name: Hayden, Michael R.
Publisher: name: BioMed Central
Year: 2017

description: Background: Copaxone is an efficacious and safe therapy that has demonstrated clinical benefit for over two decades in patients with relapsing forms of multiple sclerosis (MS). On an individual level, patients show variability in their response to Copaxone, with some achieving significantly higher response levels. The involvement of genes (e.g., HLA-DRB1*1501) with high inter-individual variability in Copaxone’s mechanism of action (MoA) suggests the potential contribution of genetics to treatment response. This study aimed to identify genetic variants associated with Copaxone response in patient cohorts from late-phase clinical trials. Methods: Single nucleotide polymorphisms (SNPs) associated with high and low levels of response to Copaxone were identified using genome-wide SNP data in a discovery cohort of 580 patients from two phase III clinical trials of Copaxone. Multivariable Bayesian modeling on the resulting SNPs in an expanded discovery cohort with 1171 patients identified a multi-SNP signature of Copaxone response. This signature was examined in 941 Copaxone-treated MS patients from seven independent late-phase trials of Copaxone and assessed for specificity to Copaxone in 310 Avonex-treated and 311 placebo-treated patients, also from late-phase trials. Results: A four-SNP signature consisting of rs80191572 (in UVRAG), rs28724893 (in HLA-DQB2), rs1789084 (in MBP), and rs139890339 (in ZAK(CDCA7)) was identified as significantly associated with Copaxone response. Copaxone-treated signature-positive patients had a greater reduction in annualized relapse rate (ARR) compared to signature-negative patients in both discovery and independent cohorts, an effect not observed in Avonex-treated patients. Additionally, signature-positive placebo-treated cohorts did not show a reduction in ARR, demonstrating the predictive as opposed to prognostic nature of the signature. A 10% subset of patients, delineated by the signature, showed marked improvements across multiple clinical parameters, including ARR, MRI measures, and higher proportion with no evidence of disease activity (NEDA). Conclusions: This study is the largest pharmacogenetic study in MS reported to date. Gene regions underlying the four-SNP signature have been linked with pathways associated with either Copaxone’s MoA or the pathophysiology of MS. The pronounced association of the four-SNP signature with clinical improvements in a ~10% subset of the MS patient population demonstrates the complex interplay of immune mechanisms and the individualized nature of response to Copaxone.
The Compost Connection for Western Agriculture, November 1999
Creators: name: Granatstein, David
Publisher: name: Washington State University Cooperative Extension
Year: 1999
Subjects: composting
Agriculture

description: Summer Compost Tours / Compost Disease Suppression in Chile Peppers / Compost Effects on Apple Tree Growth / Organic Amendments Affect Insect Biocontrol / Building Organic Content of Soil Helps Growers Boost Crop Yields / What's the Scoop on CERWA?
Toxicity of cisplatin and its metabolites on ovarian cancer cells.
Creators: name: Hosseini Shirazi, Seyed Farshad.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Health Sciences, Toxicology.

description: Cisplatin (CP) is one of our most useful antineoplastic drugs. When CP is dissolved in human plasma, different metabolites are formed. We examined the interactions of CP and its metabolites, namely aquated CP (AP), monomethionine CP (MP), bismethionine CP (BP) and CP dissolved in plasma ultrafiltrate (UP) on the OV 2008 human ovarian cancer cell line. By clonogenic assays, cell survivals (%) with AP, CP, MP, BP and UP were 3.28 $\pm$ 0.73, 9.84 $\pm$ 0.99, 15.93 $\pm$ 1.11, 76.83 $\pm$ 2.13 and 13.11 $\pm$ 0.74, respectively. AP was the most cytotoxic species, and BP was the least cytotoxic species. Cellular platinum (ng/10$\sp6$ cells) accumulation after addition of 0.33 (#1), 1.6 (#2) and 2.5 (#3) mM of each species was:(UNFORMATTED TABLE OR EQUATION FOLLOWS)$$\vbox{\halign{#\hfil&&\enspace#\hfil\cr\lbrack Species\rbrack &CP &AP &MP &BP &UP\cr\cr \#1 &289$\pm$26 &1080$\pm$90 &138$\pm$5 &24$\pm$1 &187$\pm$26\cr \#2 &607$\pm$31 &4352$\pm$145 &372$\pm$8 &56$\pm$2 &498$\pm$69\cr \#3 &713$\pm$41 &6610$\pm$279 &710$\pm$8 &78$\pm$2 &711$\pm$96\cr}}$$(TABLE/EQUATION ENDS) There is a strong correlation between cytotoxicity of the platinum species and their cellular uptake (r = 0.997). Infrared spectroscopy (IR) was done on OV 2008 cells after one hour exposure to different concentrations of species. IR data suggest that MP induced more cellular changes than the other species. While bands of all CP metabolites attributed to the phosphate and amide II stretching indicate a frequency shift and intensity variation, those of methyl and methylene stretching vibrations of the cell membrane seem to be hardly affected. In conclusion, CP and its metabolites have different effects on OV 2008 cells.
Augustine, Manichaeism and the Good.
Creators: name: Lee, Kam-Lun Edwin.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Theology.

description: This thesis will investigate, by means of the historical-critical method, Augustine of Hippo's understanding of the Manichaean idea of the Good, and how this understanding affects his own related notions of summum bonum and personal evil, and, as a corollary, his doctrine of predestination. The question of a possible Manichaean influence is particularly pertinent because Manichaeism is at heart a dualistic solution to the issue of good and evil. The focus is not on Manichaeism per se but on Augustine's perception of it, as more directly affecting his thinking. Augustine's treatise De natura boni (399) in part summarizes his treatment of "the nature of the Good" in earlier polemics. From his first writing, De pulchro et apto (380), to that point, Augustine understands the Manichaean concept as equating the Good with the Beautiful, the latter taken to mean that which engenders tranquil pleasure. Conversely, evil is thought of as a disturbance of this state, whether spiritually or physically. Wickedness and mortality are deemed to be both spiritually and physically evil in Manichaean terms because they disturb a person's tranquil existence. In his non-metaphysical theory he designs to explain intrinsic personal evil developed in De uera religione (390), Augustine redefines these two notions as "sin" and "penalty," hence imposing on them a casual relation that makes the conception of a vicious circle mechanism possible. Augustine's development of the idea of predestination reveals the Manichaean concept of the Good at work in three ways: on the framework of that development, in the implication of determinism, and on the context of the doctrine. Despite the presence of evil, he believes that the whole cosmos is in harmonious beauty so long as evil is assigned to its proper place. God is to preserve this order in both the physical and the spiritual (moral) creations, an order portrayable with a two-tiered frame. Initially (around 388), Augustine thought that an individual person, as a spiritual creature, should have self-determination by the exercise of the will. But gradually, due to his conviction that personal evil is inevitable, Augustine assigned determination of one's destiny to the jurisdiction of God. Determinism, however, is not the only characteristic feature of Augustine's version of predestination. The cosmological and eschatological contexts of his doctrine demand the notion of summum bonum to warrant the beauty of the cosmic order as well as to assure the elect's eternal tranquil beatitude. (Abstract shortened by UMI.)
Use types for English to Chinese translation of prepositions
Creators: name: Li, Hui
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Computer Science.

description: Although prepositions play an essential role in language, there is still no systematic approach for selecting the proper prepositions in a target language. This thesis explores such systemic approach and suggests a semantic framework, called Use Types, to play an important role in the automatic translation of prepositions. A Use Type gives a semantic interpretation to a context of use of a preposition based on its surrounding elements. Our hypothesis is that if we can automatically do this semantic interpretation in the source language, than we can reduce the set of possible target language prepositions. This thesis focuses on two widely spoken languages, English and Chinese. We give primary attention to translation from English to Chinese, and we specifically look at three prepositions: in, on and at. The thesis systematically analyzes the differences between Chinese prepositions and English prepositions. It explains in details what the Use Types semantic framework is and how it is used and expanded to better address the translation task. The thesis describes how machine learning experiments are designed and conducted. Results and future work are analyzed and discussed at the end. (Abstract shortened by UMI.)
Antifungal activity of Bignoniaceae plants on Aspergillus carbonarius and Aspergillus niger
Creators: name: Apud, Gisselle R.
name: Aredes-Fernández, Pedro A.
name: Kritsanida, Marina
name: Grougnet, Raphael
name: Sampietro, Diego A.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: Twenty four extracts from Bignoniaceae plants of northwest Argentina were tested for antifungal activity against Aspergillus species responsible of the grape black rot. Stems and leaves of Amphilophium cynanchoides, Macfadyena cynanchoides, Tecoma stans and Jacaranda mimosifolia were separately extracted with solvents of increasing polarity to obtain the dichloromethane (fCH2Cl2), ethyl acetate (fEtOAc) and methanol extracts (fMeOH). The fCH2Cl2 from stem of M. cynanchoides had the lowest IC50 (1.0–1.2 mg/mL) and MID values (0.6–1.2 mg) and the highest ID values (5.0–6.8 mm) on A. niger and A. carbonarius. The main contributors of the antifungal activity of fCH2Cl2 were identified as lapachol (MIC = 0.25–1.00 mg/ml) and 1-hydroxy-4-methylanthraquinone (MIC = 0.0625–0.125 mg/mL). These compounds synergized the antifungal activity of sodium metabisulfite and showed an additive effect in mixtures with propiconazol. They might be used as additives of commercial antifungals to protect grapes against A. niger and A. carbonarius.
It may not be beautiful but the new ten dollar note is pretty secure
Creators: name: Spurling, Thomas
name: Solomon, David
Publisher: name: Swinburne
Year: 2024

description: You might notice a new blue and gold addition to your wallet in the next few weeks as the Reserve Bank of Australia releases the new A$10 note into circulation. The new series of Australian banknotes are not a designer’s dream but they are the strongest yet in terms of preventing counterfeiting.
High glucose increases caspase-dependent apoptosis in inner medullary collecting duct (IMCD) cells, independent of prostaglandin E(2) (PGE2)
Creators: name: Dougherty, Monika
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Biology, Molecular.
subject: Biology, Cell.
subject: Chemistry, Biochemistry.

description: Hyperglycemia is the main determinant of diabetic nephropathy, resulting in altered renal cell growth and tubular atrophy. Additionally, prostaglandin synthesis is elevated in the diabetic kidney and may play a role in antagonizing or mediating the effects of glucose on cell growth and death. Recently, our laboratory reported that high glucose increases PGE 2 synthesis in IMCD cells, consequently, this study will determine the effect of high glucose and PGE2 on IMCD cell growth and apoptotic death. After four days high glucose exposure, there was a decrease in DNA and protein synthesis compared to low glucose. Concomitantly, high glucose treatment increased the percentage of IMCD cells displaying fragmented DNA characteristic of apoptosis, which was significantly attenuated by treatment with a pan-caspase inhibitor. Caspase-3 and/or caspase-7 activity was also augmented after four days high glucose treatment, and there was an observed increase in the expression of Bax to Bcl-2. These effects were partially mimicked by mannitol treatment. Although PGE2 treatment increased DNA and protein synthesis in the presence of indomethacin, neither indomethacin nor PGE2 altered the apoptotic response of IMCD cells in low or high glucose. To our knowledge, this study is the first to show that high glucose treatment induces IMCD cell apoptosis, coincident with a decrease in DNA and protein synthesis, and independent of PGE2.
A real-time pattern based architecture for autonomic systems
Creators: name: Solomon, Bogdan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Engineering, Electronics and Electrical.

description: Autonomic Systems are computer systems that can self-manage by ensuring that the system is optimal, correctly configured, protected and able to recover from errors with minimal to no human intervention. Applications of autonomic systems range from usage optimization for clusters of servers or virtual machines, to error prevention and error recovery for web applications. The methods used to undertake research in the area of autonomic systems are also varied, ranging from complex machine learning algorithms to simple rule-based control systems and from complex control models of the underlying system to simple policy based control systems. At present, autonomic system structures are missing a key component - a robust, reusable, and standard architecture based on patterns. This would simplify the design and implementation of autonomic computing systems. Autonomic systems are often designed and developed following a monolithic pattern which leads to a replication of development efforts when parts of the system are later used in a different approach. In this thesis, an architecture rooted in real-time control systems is introduced and its corresponding detail design is described. The development of the architecture is based on Model-Driven Development principles. Furthermore, the thesis presents and develops various models for the control of autonomic systems. The models used allow for an easy interchange of components via composition/decomposition mechanisms. It is thus demonstrated how the framework developed based on the proposed architecture can be easily reconfigured for the control and supervision of different types of autonomic computing strategies such as self-management for Web Services or self-optimization for Server Virtualization. Experiments on and with the above new autonomic computing methodology for various computing paradigms are given to support the design and the implementation described.
Development of an adaptive weight unit.
Creators: name: Tarry, Robert J.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1964
Subjects: subject: Engineering, Electronics and Electrical.

description: The subject of this thesis is the design and evaluation of an adaptive weight unit based on the transfluxor magnetic core. The search for multi-level or analog storage devices has led to the study and development of many different types of storage mechanisms, ranging from mechanical and chemical devices to magnetic core devices. This thesis presents the characteristics of a special type of magnetic core, called the transfluxor, used as an adaptive weight element. Design criteria and limits have been established and the relationship of component tolerance and stability of operation is discussed. A number of weight units were constructed and were used in conjuction with a threshold logic unit in order to demonstrate the dynamic characteristics of the weight units. Simple tests were carried out on this system and the results are presented. Conclusions are drawn as to the success of the design.
Thabena litaoensis Yang 1994
Creators: name: Gnezdilov, Vladimir M.
name: Thierry, Bourgoin
name: Soulier-Perkins, Adeline
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Issidae
Thabena
Thabena litaoensis

description: Thabena litaoensis Yang, 1994
Gelastyrella litaoensis Yang, 1994: 90 (in Chan & Yang, 1994). Gelastyrella hainanensis Ran et Liang, 2006: 65, figs 1–8, syn. n. Thabena litaoensis Gnezdilov, 2009: 80. Thabena hainanensis Gnezdilov, 2009: 80.
Material examined (MNHN). Vietnam: 1♂ 1♀, “Museum Paris, Tonkin, Hoa Binh, J. de Cooman, R. Oberthur 1919”; 2♂ 2♀, “Museum Paris, Tonkin, rég. de Hoa Binh, A. de Cooman 1926”; 2♀, “Museum Paris, Tonkin, rég. de Hoa Binh, A. de Cooman 1928”; 1♀, “Museum Paris, Tonkin, rég. de Hoa Binh, A. de Cooman 1929”.
Distribution. China (Hainan) (Ran & Liang, 2006a; Zhang & Chen 2012), Taiwan (Chan & Yang, 1994), Vietnam (new record).
Note. The drawings of male genitalia of T. litaoensis and T. hainanensis were compared and the species found conspecific as the structure of penis is very peculiar according to the cap-shaped apical lobe and very different from other species of the genus. Diagnostic characters mentioned for T. hainanensis in the original description (Ran & Liang, 2006) are only the coloration of coryphe (vertex) and the number of apical spines on hind tibia. These charactres are more variable in comparison with male genitalia and may be treated as interspecific variation between the island populations. Finally both names were mentioned from Hainan (Zhang & Chen 2012) which also confirms our point of view.
The genus Thabena is Indo-Malayan and currently groups 14 species distributed in China, Indonesia, Malaysia, Philippines, Singapore, Taiwan, and Thailand (Gnezdilov, 2009, 2013b). Thabena brunnifrons (Bonfils, Attié et Reynaud, 2001) described from Réunion was probably imported from Asia to this island (Gnezdilov, 2009) and Thabena fissala (Fieber, 1876) described from Portugal by Fieber might be due to an error of locality (Gnezdilov et al., 2011). As it could have been expected, this genus is now found also in northern Vietnam.
description: Published as part of Gnezdilov, Vladimir M., Thierry, Bourgoin & Soulier-Perkins, Adeline, 2014, Vietnamese Issidae (Hemiptera, Fulgoroidea): new taxa, new records and new distribution data in Zootaxa 3847 (1), DOI: 10.11646/zootaxa.3847.1.4, http://zenodo.org/record/231549
Determination of acetylcholinesterase and α-glucosidase inhibition by electrophoretically-mediated microanalysis and phenolic profile by HPLC-ESI-MS/MS of fruit juices from Brazilian Myrtaceae Plinia cauliflora (Mart.) Kausel and Eugenia uniflora L.
Creators: name: Siebert, Diogo Alexandre
name: Mello, Flávia De
name: Alberton, Michele Debiasi
name: Vitali, Luciano
name: Micke, Gustavo Amadeu
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 60506 Virology

description: Alzheimer’s disease and diabetes mellitus are contemporary diseases of great concern. Phenolic compounds are linked to several health benefits and could lead to novel strategies to combat these ailments. The objective of this study was to evaluate by electrophoretically-mediated microanalysis the potential inhibitory activity of the fruit juices from Plinia cauliflora (“jaboticaba”) and Eugenia uniflora (“pitanga”) toward acetylcholinesterase (AChE) and α-glucosidase, target enzymes in strategies for the treatment of these diseases. The phenolic profiles of the samples were also investigated. Jaboticaba and pitanga juices inhibited 85.90 ± 1.73 and 52.67 ± 1.24% of AChE activity at 5 mg mL−1, and 57.91 ± 2.60 and 69.47 ± 2.89% of α-glucosidase activity at 1 mg mL−1, respectively. Total phenolic content of the juices were 303.54 ± 28.28 and 367.00 ± 11.42 mgGA L−1, respectively. The observed inhibitory activity can be explained, at least in part, by the presence of the phenolic compounds.
Pseudochoutagus Che, Zhang and Wang
Creators: name: Che, Yanli
name: Zhang, Yalin
name: Wang, Yinglun
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Issidae
Pseudochoutagus

description: Pseudochoutagus Che, Zhang and Wang, new genus
Type species: Pseudochoutagus curvativus sp. nov.
Description. Body hemispherical. Head (including eyes) distinctly narrower than pronotum. Vertex much longer than broad, more or less triangular with median carina present in dorsal view, apex upcurved in lateral view. Ocelli present. Frons slightly elevated, disc finely granulose, median carina present. Frontoclypeal suture strongly arched. Clypeus with medial carina. Rostrum long, reaching to metatrochanter. Pronotum narrow, with two central pits; anterior margin distinctly convex; posterior margin nearly truncate. Mesoscutellum more or less triangular, with one pit along each lateral margin. Tegmen thickly and coarsely reticulate; claval suture present. Wing well-developed, longer than half length of tegmen, with two lobes, veins distinct and netlike. Legs relatively long, not dilated; lateral margin of hind tibia with two teeth. Spinulation formula of hind leg 7-11-2 (numbers of spines at apex of hind tibia, first and second tarsomeres, respectively). Male genitalia symmetrical; aedeagus tubular, with two spinous processes near mid-length.
Diagnosis. The genus is readily separated from others in the tribe of Issini by its long upturned vertex.
The new genus superficially resembles Choutagus Zhang, Wang and Che, 2006 (Hemisphaeriinae) in its extended head, but can be distinguished from the latter by: 1) tegmen with claval suture present (absent in Choutagus); 2) hind wing bilobed (not bilobed in Choutagus); 3) apex of vertex upturned (nearly horizontal in Choutagus); 4) head and thorax without lateral carinae, and pronotum and mesoscutellum without median and lateral carinae (all carinae present in Choutagus).
Within its own tribe, Pseudochoutagus is also similar to Thabena Stål, 1866 (Issini) according to the bilobed hind wings with deep cleft between the remigium and vannus, and a large process on the hind margin of female sternum VII. It differs from this genus by: 1) head (including eyes) distinctly narrower than pronotum (nearly equal in Thabena); 2) vertex much longer than broad, more or less triangular and with median carina present (vertex approximately quadrangular, broader than long and median carina absent in Thabena); 3) vertex with apex upcurved in lateral view (nearly horizontal in Thabena).
Etymology. Pseudochoutagus refers to the superficial resemblance of this genus to Choutagus Zhang, Wang and Che. The gender is masculine.
Distribution. China (Hainan).
description: Published as part of Che, Yanli, Zhang, Yalin & Wang, Yinglun, 2011, A new genus of the tribe Issini Spinola (Hemiptera: Fulgoroidea: Issidae) from China, pp. 62-66 in Zootaxa 3060 on page 63, DOI: 10.5281/zenodo.204450
Antimicrobial sensing and resistance in Clostridioides difficile
Creators: name: Pannullo, Anthony
Publisher: name: University of Iowa
Year: 2024
Subjects: Antibiotic Resistance
C. difficile
lysozyme resistance
Membrane lipids
Two component systems
public abstract

description: Clostridioides difficile is the most common cause of hospital-acquired diarrhea, causing ~250,000 infections and ~13,000 deaths in the US each year, with an estimated annual medical burden of $1 billion. C. difficile is resistant to a wide range of antimicrobials. One such antimicrobial, lysozyme, is an important component of innate immunity in humans. Lysozyme resistance in C. difficile is primarily conferred through the ECF sigma factor σV. The σV regulon contains the peptidoglycan (PG) deacetylase PdaV, which works in conjunction with another peptidoglycan deacetylase, PgdA. Activity of σV in C. difficile is regulated by the anti-sigma factor, RsiV. We have found that degradation of RsiV occurs in the presence of lysozyme through regulated intramembrane proteolysis (RIP). RIP is a two-step process involving the site-1 protease signal peptidase and the site-2 protease RasP. We found that strains lacking RasP were not able to completely degrade RsiV and accumulated an intermediate product. We also found that mutating residues forming the signal peptide in RsiV that is recognized by signal peptidases prevents degradation. We identified 3 two-component systems (TCS) involved in lysozyme resistance in C. difficile including cdr1313-1314, cdr1880-1879, and cdr2457-2456 (DraRS). These TCS’s were identified through a lysozyme resistance selection using a lysozyme sensitive strain which lacks σV and its operon. We also found that DraR was involved in daptomycin and bacitracin resistance. Utilizing a PdraR-slucopt reporter we found that DraRS responds to a subset of lipid II-inhibiting antimicrobials. We also identified a gene cluster, referred to as the hex cluster, through a Tn-seq experiment in which we were looking for genes that were conditionally essential in the presence of daptomycin. We identified the TCS HexRK and its regulon, HexSDF. According to RNA-seq hex becomes induced in the presence of daptomycin as well as when DraR is overproduced. HexSDF is necessary for the synthesis of the C. difficile unique glycolipid, HNHDRG. Strains lacking HexSDF became dramatically more sensitive to daptomycin and bacitracin.
LA SOCIEDAD NACIONAL DE LA CRUZ ROJA CUBANA EN EL SIGLO XXI.  Su Autonomía y Patrimonio con el organismo de relación
Creators: name: Alcides Francisco Antúnez Sánchez
Publisher: name: Zenodo
Year: 2012

description: SUMARIO: 1.Orígenes de la Sociedad Nacional de la Cruz Roja Cubana. 1.1 Periodo de trabajo antes de 1959. 1.2 Periodo de trabajo desde 1959-1985, 1.3 Periodo de trabajo desde 1986-1995, 1.4 Periodo de trabajo desde 1996-2008  2. Legitimidad de la Sociedad Nacional de la Cruz Roja Cubana y si inscripción en el Registro de Asociaciones del Ministerio de Salud Pública. 3.- La Sociedad Nacional de la Cruz Roja dentro de la Ley de la Salud Pública en el derecho positivo cubano. 4. La autonomía y el patrimonio de la Sociedad Nacional de la Cruz Roja Cubana dentro del Sistema de la Salud en Cuba. 5. La Cruz Roja Cubana en el siglo XXI. 5.1 Proyecciones de trabajo de la sociedad cubana de la Cruz Roja. 6. Bibliografía.
Mobile technology and Canadian commercial radio: Friends or foes?
Creators: name: Salewski, William Shawn
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Multimedia Communications.
subject: Mass Communications.

description: A defining aspect of our era is the continuous migration of media consumers toward alternative distribution platforms. These are used to access content formerly available only in traditional media's original format. The intensification of wireless networks and the increasing portability of content, music content in particular, has resulted in radio listeners reverting to wireless delivery technologies to access, discover, listen to, share and store music. This empirical research project explores the consequences of mobile technology on commercial radio by looking at the ways in which mobility is altering the relationship between commercial radio and music fans. The specific research objectives of this study are threefold: (1) to better understand the increasing role of the mobile industry and of wireless delivery technologies as purveyors of music; (2) to explore their repercussions on the viability of commercial radio; and (3) to identify the appearance of effects on the habits and expectations of radio listeners.