cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
n-Valued Refined Neutrosophic Logic and Its Applications to Physics
Creators: name: Smarandache, Florentin
Publisher: name: arXiv
Year: 2014
Subjects: subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences
subject: 28E10

description: In this paper we present a short history of logics: from particular cases of 2-symbol or numerical valued logic to the general case of n-symbol or numerical valued logic. We show generalizations of 2-valued Boolean logic to fuzzy logic, also from the Kleene and Lukasiewicz 3-symbol valued logics or Belnap 4-symbol valued logic to the most general n-symbol or numerical valued refined neutrosophic logic. Two classes of neutrosophic norm (n-norm) and neutrosophic conorm (n-conorm) are defined. Examples of applications of neutrosophic logic to physics are listed in the last section. Similar generalizations can be done for n-Valued Refined Neutrosophic Set, and respectively n- Valued Refined Neutrosopjhic Probability.
description: 9 pages
A Remote Patient Monitoring System for Congestive Heart Failure
Creators: name: Tu, Michael Kai
name: Suh, Myung-kyung
name: Woodbridge, Jonathan
name: Kim, Jung In
name: Sarrafzadeh, Majid
name: Nahapetian, Ani
name: Evangelista, Lorraine S.
name: Chen, Chien-An
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Congestive heart failure (CHF) is a leading cause of death in the United States affecting approximately 670,000 individuals. Due to the prevalence of CHF related issues, it is prudent to seek out methodologies that would facilitate the prevention, monitoring, and treatment of heart disease on a daily basis. This paper describes WANDA (Weight and Activity with Blood Pressure Monitoring System); a study that leverages sensor technologies and wireless communications to monitor the health related measurements of patients with CHF. The WANDA system is a three-tier architecture consisting of sensors, web servers, and back-end databases. The system was developed in conjunction with the UCLA School of Nursing and the UCLA Wireless Health Institute to enable early detection of key clinical symptoms indicative of CHF-related decompensation. This study shows that CHF patients monitored by WANDA are less likely to have readings fall outside a healthy range. In addition, WANDA provides a useful feedback system for regulating readings of CHF patients.
High Energy Colliding Beams; What Is Their Future?
Creators: name: Richter, Burton
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: The success of the first few years of LHC operations at CERN, and the expectation of more to come as the LHC performance improves, are already leading to discussions of what should be next for both proton-proton and electron-positron colliders. In this discussion I see too much theoretical desperation caused by the so far unsuccessful hunt for what is beyond the Standard Model, and too little of the necessary interaction of the accelerator, experimenter, and theory communities necessary for a scientific and engineering success. Here, I give my impressions of the problem, its possible solution, and what is needed to have both a scientifically productive and financially viable future.
description: 12 pages, 0 figures
Reactivation of herpes simplex virus type 1 is associated with cytomegalovirus and age
Creators: name: Peek, M. Kristen
name: Cutchin, Malcolm P.
name: Goodwin, James S.
name: Stowe, Raymond P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Recent studies have shown that Cytomegalovirus (CMV) may be an emerging marker of immunosenescence. CMV can affect the immune system by directly infecting leukocytes and hematopoietic cells or by eliciting an expansion of oligoclonal CD8+ T cells/contraction of the naïve T cell compartment that may reduce the host’s ability to fight other pathogens. To investigate further CMV-associated changes in immunity, a study was conducted with 1,454 adults (ages 25–91) to determine the association between CMV and reactivation of another latent herpesvirus, Herpes simplex virus type 1 (HSV-1), as indexed by antibody titers. Elevated antibody titers to latent HSV-1 were significantly associated with both CMV seropositivity and high CMV antibody levels. Evaluation by specific age groups (<45, 45–64, and 65+ years old) revealed that this association was detectable early in life (<45 years of age). Increases in HSV-1 antibodies by age occurred in CMV seropositive individuals but not CMV seronegative subjects. Within CMV seropositive subjects, increases in HSV-1 antibodies by age were only found in individuals with low CMV antibody levels as those with high CMV antibodies already exhibited elevated HSV-1 antibodies. These associations remained significant after accounting for body mass index, gender, and socioeconomic status. These results suggest that CMV can influence the immune response to another pathogen and support the concept that CMV may accelerate immunosenescence.
Characterization of HIV drug resistance mutations among patients failing first-line antiretroviral therapy from a tertiary referral center in Lusaka, Zambia: Sequence Analysis of HIV DRMs in Lusaka, Zambia
Creators: name: Lambwe, Nason
name: Sikazwe, Izukanji
name: Guffey, M. Bradford
name: Seu, Lillian
name: Siwingwa, Mpanji
name: Mulenga, Lloyd B.
name: Chi, Benjamin H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: In settings of resource constraint, an understanding of HIV drug resistance can guide antiretroviral therapy (ART) at switch to second-line therapy. To determine the prevalence of such HIV drug resistance mutations (HIV DRM), we used an in-house sequencing assay in the pol gene (protease and partial reverse transcriptase) in a cohort of patients suspected of failing a first-line regimen, which in Zambia comprises two nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) and one non-nucleoside reverse transcriptase inhibitor (NNRTI). Our analysis cohort (n=68) was referred to the University Teaching Hospital in Lusaka from November 2009 to October 2012. Median duration on first-line ART to suspected treatment failure was 3.2 years (IQR 1.7–4.7 years). The majority of patients (95%) harbored HIV-1 subtype C virus. Analysis of reverse transcriptase revealed M184V (88%), K103N/S (32%), and Y181C/I/V (41%) DRMs, with the latter conferring reduced susceptibility to the salvage therapy candidates etravirine and rilpivirine. Three patients (5%) had major protease inhibitor (PI) resistance mutations: all three had the V82A mutation, and one patient (Clade J virus) had a concurrent M46I, Q58E, and L76V DRM. HIV-1 genotyping revealed major and minor DRMs as well as high levels of polymorphisms in subtype C isolates from patients failing first-line antiretroviral therapy. Closer monitoring of DRM mutations at first-line failure can inform clinicians about future options for salvage therapy.
title: An assessment of the concordance between an increase in intracranial pressure of invasively monitored patients with traumatic brain injury and radiological deterioration
Creators: name: Czapran, Philippa
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Trauma
subject: Technology assessment
subject: Equipment
subject: CT
subject: Trauma
subject: Neuroradiology brain

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Raised intracranial pressure (ICP) is a well recognised sequelae of traumatic brain injury and as a consequence invasive ICP monitoring is now relatively ubiquitous practice in neurointensive care. The Brain Trauma Foundation (BTF) Guidelines 3rd...
Precision measurements of θ12 for testing models of discrete leptonic flavour symmetries
Creators: name: Ballett, Peter
name: King, Stephen F.
name: Luhn, Christoph
name: Pascoli, Silvia
name: Schmidt, Michael A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Models of leptonic flavour with discrete symmetries can provide an attractive explanation of the pattern of elements found in the leptonic mixing matrix. The next generation of neutrino oscillation experiments will allow the mixing parameters to be tested to a new level of precision, crucially measuring the CP violating phase δ for the first time. In this contribution, we present results of a systematic survey of the predictions of a class of models based on residual discrete symmetries and the prospects for excluding such models at medium- and long-term oscillation experiments. We place particular emphasis on the complementary role that a future circa 50 km reactor experiment, e.g. JUNO, can play in constraining these models.
description: 3 pages, 1 figure; contribution to conference proceedings for NuPhys2013
title: Does contrast enhanced ultrasound have a role in the malignant axilla
Creators: name: Sharma, Nisha
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Breast
subject: Lymph nodes
subject: Oncology
subject: Ultrasound
subject: Biopsy
subject: Contrast agent-other
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The aim of this study is to see if we can reliably assess the tumour cell burden in the axillary lymph nodes using contrast enhanced ultrasound (CEUS) and axillary biopsy before and after chemotherapy, in women with breast cancer and...
Discovery Prospects for NMSSM Higgs Bosons at the High-Energy Large Hadron Collider
Creators: name: King, S. F.
name: Muhlleitner, M.
name: Nevzorov, R.
name: Walz, K.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We investigate the discovery prospects for NMSSM Higgs bosons during the 13~TeV run of the LHC. While one of the neutral Higgs bosons is demanded to have a mass around 125~GeV and Standard Model (SM)-like properties, there can be substantially lighter, nearby or heavier Higgs bosons, that have not been excluded yet by LEP, Tevatron or the 8~TeV run of the LHC. The challenge consists in discovering the whole NMSSM Higgs mass spectrum. We present the rates for production and subsequent decay of the neutral NMSSM Higgs bosons in the most promising final states and discuss their possible discovery. The prospects for pinning down the Higgs sector of the Natural NMSSM will be analysed taking into account alternative search channels. We give a series of benchmark scenarios compatible with the experimental constraints, that feature Higgs-to-Higgs decays and entail (exotic) signatures with multi-fermion and/or multi-photon final states. These decay chains furthermore give access to the trilinear Higgs self-couplings. We briefly discuss the possibility of exploiting coupling sum rules in case not all the NMSSM Higgs bosons are discovered.
Identification of potent, selective P2Y-purinoceptor agonists: structure-activity relationships for 2-thioether derivatives of adenosine 5'-triphosphate
Creators: name: Knight, Gillian E.
name: Fischer, Bilha
name: Boyer, Jose L.
name: Zimmet, Jeffrey
name: Burnstock, Geoffrey
name: Ziganshin, Airat U.
name: Jacobson, Kenneth A.
name: Hoyle, Charles H. V.
name: Harden, T. Kendall
name: Brizzolara, Antonia L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: Study of P2-purinoceptor subtypes has been difficult due to the lack of potent and selective ligands. With the goal of developing high affinity P2-purinoceptor-selective agonists, we have synthesized a series of analogues of adenine nucleotides modified on the purine ring as chain-extended 2-thioethers or as N6-methyl-substituted compounds. Chemical functionality incorporated in the thioether moiety included cyanoalkyl, nitroaromatic, amino, thiol, cycloalkyl, n-alkyl, and olefinic groups. Apparent affinity of the compounds for P2Y-purinoceptors was established by measurement of P2Y-purinoceptor-promoted phospholipase C activity in turkey erythrocyte membranes and relaxation of carbachol-contracted smooth muscle in three different preparations (guinea pig taenia coil, rabbit aorta, and rabbit mesenteric artery). Activity at P2X-purinoceptors was established by measurement of contraction of rabbit saphenous artery and of the guinea pig vas deferens and urinary bladder. All 11 of the 2-thioethers of ATP stimulated the production of inositol phosphates with K0.5 values of 1.5–770 nM, with an (aminophenyl)ethyl derivative being most potent. Two adenosine diphosphate analogues were equipotent to the corresponding ATP analogues. Adenosine monophosphate analogues were full agonists, although generally 4 orders of magnitude less potent. ATP 2-thioethers displayed pD2 values in the range of 6–8 in smooth muscle assay systems for activity at P2Y-receptors. There was a significant correlation for the 2-thioether compounds between the pK0.5 values for inositol phosphate production and the pD2 values for relaxation mediated via the P2Y-purinoceptors in the guinea pig taenia coli, but not for the vascular P2Y-receptors or for the P2X-receptors. At P2X-receptors, no activity was observed in the rabbit saphenous artery, but variable degrees of activity were observed in the guinea pig vas deferens and bladder depending on distal substituents of the thioether moiety. N6-Methyl-ATP was inactive at P2X-receptors, and approximately equipotent to ATP at taenia coli P2Y-receptors. This suggested that hybrid N6-methyl and 2-thioether ATP derivatives might be potent and selective for certain P2Y-receptors, as was shown for one such derivative, N6-methyl-2-(5-hexenylthio)-ATP.
Additional file 1 of How often do cancer researchers make their data and code available and what factors are associated with sharing?
Creators: name: Hamilton, Daniel G.
name: Page, Matthew J.
name: Finch, Sue
name: Everitt, Sarah
name: Fidler, Fiona
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Additional file 1: Table 1. Characteristics of included studies by sharing type (N=306).
Ext Data File 4 CEACAM6_Articles_Blood transcript profiling_Step4c_2022 Sep14
Creators: name: Chaussabel, Damien
Publisher: name: figshare
Year: 2022
Subjects: Biomarkers

description: Extended Data File 4: a spreadsheet in the MS Excel format used to capture information from the CEACAM6 literature reporting differences in blood transcript abundance in cases vs controls
title: Colpocistodefecography with Barium in the small bowel: technique, findings and preparation of the report.
Creators: name: Regaña Feijoó, María José
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Abdomen
subject: Pelvis
subject: Genital / Reproductive system female
subject: Fluoroscopy
subject: Image manipulation / Reconstruction
subject: Defecography
subject: Diagnostic procedure
subject: Technical aspects
subject: Pelvic floor dysfunction

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Review of the technique, the indications and the findings that we can find, presenting cases of the various pathologies that we will review. First of all, we explain the preparation prior to carrying out the patient's test and the material and...
Ψυχιατρική αντιμετώπιση επιζώντων και στήριξη οικογενειών των θυμάτων από μαζικές καταστροφές – ο ρόλος των Ενόπλων Δυνάμεων στη διαχείριση των μαζικών καταστροφών
Creators: name: Τσιαμούρα, Μαγδαληνή Θεόφιλου
Publisher: name: Aristotle University of Thessaloniki
Year: 2024
Subjects: Μαζική καταστροφή
Θύματα
Ψυχοκοινωνικές επιπτώσεις
Mass destruction
Victims
Psychosocial effects

description: Την τελευταία χρονική περίοδο, η χώρα μας έχει πληγεί επανειλημμένα από πληθώρα μαζικών καταστροφών, πρωτοφανών για τα δεδομένα μας. Οι καταστροφές επιφέρουν μεγάλου εύρους απώλειες και βλάβες, τόσο σε ατομικό, όσο και σε κοινωνικό επίπεδο. Ανάμεσα στις πιο δυσάρεστες συνέπειες των μαζικών καταστροφών είναι οι ψυχικές διαταραχές. Αντικείμενο της παρούσας εργασίας είναι η βιβλιογραφική ανασκόπηση, που αφορά την αντιμετώπιση των ψυχικών διαταραχών που εμφανίζονται στους πληγέντες για τα ελληνικά δεδομένα, καθώς επίσης και η συμβολή των Ενόπλων Δυνάμεων της χώρας μας, στη διαχείριση των μαζικών καταστροφών. Πιστεύουμε ότι τα συμπεράσματα της συγκεκριμένης εργασίας θα συμβάλουν στην καλύτερη κατανόηση του ρόλου των ειδικών ψυχικής υγείας, καθώς επίσης και των Ενόπλων Δυνάμεων στη διαχείριση εκτάκτων αναγκών, ώστε να φανούν χρήσιμα στην εκπόνηση σχεδίων, για αποτελεσματικότερη παρέμβαση του κρατικού μηχανισμού.
description: Recently, our country has been hit on multiple occasions by unforeseen mass destructions. Undoubtedly, disasters of this range cause many damages, both individually and socially. Psychiatric disorders consist among others, one of the most unpleasant consequence of mass destructions. This paper has the purpose to analyze the approach of medical experts to psychiatric disorders in victims, as well as the contribution of Greek Armed Forces to crisis response. As a result this paper aims to elucidate the importance of emergency management, aiming furthermore to generate immediate and more effective action of state in the future.
Closing the stop gap
Creators: name: Czakon, Michal
name: Mitov, Alexander
name: Papucci, Michele
name: Ruderman, Joshua T.
name: Weiler, Andreas
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Light stops are a hallmark of the most natural realizations of weak-scale supersymmetry. While stops have been extensively searched for, there remain open gaps around and below the top mass, due to similarities of stop and top signals with current statistics. We propose a new fast-track avenue to improve light stop searches for R-parity conserving supersymmetry, by comparing top cross section measurements to the theoretical prediction. Stop masses below ~ 180 GeV can now be ruled out for a light neutralino. The possibility of a stop signal contaminating the top mass measurement is also briefly addressed.
description: 6 pages, 6 figures
AMIR TEMUR VA BOYAZID YILDIRIM O'RTASIDAGI "ANQARA JANGI"
Creators: name: Teshayeva, Gulira'no
Publisher: name: Zenodo
Year: 2024

description: 1402-yil 20-iyul kuni hozirgi Turkiya davlati hududida joylashgan Anqara shahri yaqinida asrning eng dahshatli muhorabalaridan biri bo‘lib o‘tadi. Zamonasining ikki buyuk davlati — Usmoniylar va Temuriylar saltanati qo‘shini shu yerda to‘qnashadi.
Human P2Y 1 Receptor:  Molecular Modeling and Site-Directed Mutagenesis as Tools To Identify Agonist and Antagonist Recognition Sites
Creators: name: Harden, T. Kendall
name: Camaioni, Emidio
name: Moro, Stefano
name: Boyer, José L.
name: Jacobson, Kenneth A.
name: Guo, Danping
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: The molecular basis for recognition by human P2Y1 receptors of the novel, competitive antagonist 2′-deoxy-N6-methyladenosine 3′,5′-bisphosphate (MRS 2179) was probed using site-directed mutagenesis and molecular modeling. The potency of this antagonist was measured in mutant receptors in which key residues in the transmembrane helical domains (TMs) 3, 5, 6, and 7 were replaced by Ala or other amino acids. The capacity of MRS 2179 to block stimulation of phospholipase C promoted by 2-methylthioadenosine 5′-diphosphate (2-MeSADP) was lost in P2Y1 receptors having F226A, K280A, or Q307A mutations, indicating that these residues are critical for the binding of the antagonist molecule. Mutation of the residues His132, Thr222, and Tyr136 had an intermediate effect on the capacity of MRS 2179 to block the P2Y1 receptor. These positions therefore appear to have a modulatory role in recognition of this antagonist. F131A, H277A, T221A, R310K, or S317A mutant receptors exhibited an apparent affinity for MRS 2179 that was similar to that observed with the wild-type receptor. Thus, Phe131, Thr221, His277, and Ser317 are not essential for antagonist recognition. A computer-generated model of the human P2Y1 receptor was built and analyzed to help interpret these results. The model was derived through primary sequence comparison, secondary structure prediction, and three-dimensional homology building, using rhodopsin as a template, and was consistent with data obtained from mutagenesis studies. We have introduced a “cross-docking” procedure to obtain energetically refined 3D structures of the ligand–receptor complexes. Cross-docking simulates the reorganization of the native receptor structure induced by a ligand. A putative nucleotide binding site was localized and used to predict which residues are likely to be in proximity to agonists and antagonists. According to our model TM6 and TM7 are close to the adenine ring, TM3 and TM6 are close to the ribose moiety, and TM3, TM6, and TM7 are near the triphosphate chain.
Adenine Nucleotide Analogues Locked in a Northern Methanocarba Conformation:  Enhanced Stability and Potency as P2Y 1 Receptor Agonists
Creators: name: Jacobson, Kenneth A.
name: Maddileti, Savitri
name: Zimmermann, Herbert
name: Lee, Kyeong
name: Boyer, José L.
name: Ravi, R. Gnana
name: Servos, Jörg
name: Kim, Hak Sung
name: Harden, T. Kendall
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Preference for the Northern (N) ring conformation of the ribose moiety of nucleotide 5′-triphosphate agonists at P2Y1, P2Y2, P2Y4, and P2Y11 receptors, but not P2Y6 receptors, was established using a ring-constrained methanocarba (a 3.1.0-bicyclohexane) ring as a ribose substitute (Kim et al. J. Med. Chem. 2002, 45, 208–218.). We have now combined the ring-constrained (N)-methanocarba modification of adenine nucleotides with other functionalities known to enhance potency at P2 receptors. The potency of the newly synthesized analogues was determined in the stimulation of phospholipase C through activation of turkey erythrocyte P2Y1 or human P2Y1 and P2Y2 receptors stably expressed in astrocytoma cells. An (N)-methanocarba-2-methylthio-ADP analogue displayed an EC50 at the hP2Y1 receptor of 0.40 nM and was 55-fold more potent than the corresponding triphosphate and 16-fold more potent than the riboside 5′-diphosphate. 2-Cl–(N)-methanocarba-ATP and its N6-Me analogue were also highly selective, full agonists at P2Y1 receptors. The (N)-methanocarba-2-methylthio and 2-chloromonophosphate analogues were full agonists exhibiting micromolar potency at P2Y1 receptors, while the corresponding ribosides were inactive. Although β,γ-methylene-ATP was inactive at P2Y receptors, β,γ-methylene-(N)-methanocarba-ATP was a potent hP2Y1 receptor agonist with an EC50 of 160 nM and was selective versus hP2Y2 and hP2Y4 receptors. The rates of hydrolysis of Northern (N) and Southern (S) methanocarba analogues of AMP by rat 5′-ectonucleotidase were negligible. The rates of hydrolysis of the corresponding triphosphates by recombinant rat NTPDase1 and 2 were studied. Both isomers were hydrolyzed by NTPDase 1 at about half the rate of ATP hydrolysis. The (N) isomer was hardly hydrolyzed by NTPDase 2, while the (S) isomer was hydrolyzed at one-third of the rate of ATP hydrolysis. This suggests that new, more stable and selective nucleotide agonists may be designed on the basis of the (N)-conformation, which greatly enhanced potency at P2Y1 receptors.
Upper-Level Physics Students' Perceptions of Physicists
Creators: name: Irving, Paul W.
name: Sayre, Eleanor C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Physics Education (physics.ed-ph)
subject: FOS: Physical sciences

description: As part of a longitudinal study into identity development in upper-level physics students, we used a phenomenographic research method to examine students' perceptions of what it means to be a physicist. The results revealed four different categories. We find a clear distinction in the exclusivity students associate with being a physicist and the differences in the importance of research and its association with being a physicist. A relationship between perceptions of physicists and goal orientation is indicated.
description: 2 pages, a poster-paper from ICLS 2014
title: Outcomes of urgent-start peritoneal dialysis catheter placement via radiologic versus laparoscopic techniques
Creators: name: Abdel Aal, Ahmed
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Interventional non-vascular
subject: Fluoroscopy
subject: Catheters
subject: Radiotherapy techniques

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The majority of patients with end stage renal disease start unplanned hemodialysis via central venous catheter which proved to have significant drawbacks. An alternative approach is the urgent-start peritoneal dialysis. Peritoneal dialysis...
Methanocarba Modification of Uracil and Adenine Nucleotides:  High Potency of Northern Ring Conformation at P2Y 1 , P2Y 2 , P2Y 4 , and P2Y 11 but Not P2Y 6 Receptors
Creators: name: Malmsjö, Malin
name: Jacobson, Kenneth A.
name: Boyer, José L.
name: Ravi, R. Gnana
name: Wihlborg, Anna-Karin
name: Erlinge, David
name: Marquez, Victor E.
name: Maddileti, Savitri
name: Kim, Hak Sung
name: Harden, T. Kendall
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: The potency of nucleotide antagonists at P2Y1 receptors was enhanced by replacing the ribose moiety with a constrained carbocyclic ring (Nandanan, et al. J. Med. Chem. 2000, 43, 829—842). We have now synthesized ring-constrained methanocarba analogues (in which a fused cyclopropane moiety constrains the pseudosugar ring) of adenine and uracil nucleotides, the endogenous activators of P2Y receptors. Methanocarba-adenosine 5′-triphosphate (ATP) was fixed in either a Northern (N) or a Southern (S) conformation, as defined in the pseudorotational cycle. (N)-Methanocarba-uridine was prepared from the 1-amino-pseudosugar ring by treatment with β-ethoxyacryloyl cyanate and cyclization to form the uracil ring. Phosphorylation was carried out at the 5′-hydroxyl group through a multistep process: Reaction with phosphoramidite followed by oxidation provided the 5′-monophosphates, which then were treated with 1,1′-carbonyldiimidazole for condensation with additional phosphate groups. The ability of the analogues to stimulate phospholipase C through activation of turkey P2Y1 or human P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11 receptors stably expressed in astrocytoma cells was measured. At recombinant human P2Y1 and P2Y2 receptors, (N)-methanocarba-ATP was 138- and 41-fold, respectively, more potent than racemic (S)-methanocarba-ATP as an agonist. (N)-methanocarba-ATP activated P2Y11 receptors with a potency similar to ATP. (N)-Methanocarba-uridine 5′-triphosphate (UTP) was equipotent to UTP as an agonist at human P2Y2 receptors and also activated P2Y4 receptors with an EC50 of 85 nM. (N)-Methanocarba-uridine 5′-diphosphate (UDP) was inactive at the hP2Y6 receptor. The vascular effects of (N)-methanocarba-UTP and (N)-methanocarba-UDP were studied in a model of the rat mesenteric artery. The triphosphate was more potent than UTP in inducing a dilatory P2Y4 response (pEC50 = 6.1 ± 0.2), while the diphosphate was inactive as either an agonist or antagonist in a P2Y6 receptor-mediated contractile response. Our results suggest that new nucleotide agonists may be designed on the basis of the (N) conformation that favors selectivity for P2Y1, P2Y2, P2Y4, and P2Y11 receptors.
Additional file 1 of Clinical improvement of DM1 patients reflected by reversal of disease-induced gene expression in blood
Creators: name: van Cruchten, Remco T. P.
name: van As, Daniël
name: Glennon, Jeffrey C.
name: van Engelen, Baziel G. M.
name: ‘t Hoen, Peter A. C.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: Computational Biology

description: Additional file 1: Table S1. PCR duplicates.
Dialectics of Counting and the Mathematics of Vagueness
Creators: name: Mani, A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Logic (math.LO)
subject: FOS: Mathematics

description: New concepts of rough natural number systems are introduced in this research paper from both formal and less formal perspectives. These are used to improve most rough set-theoretical measures in general Rough Set theory (\textsf{RST}) and to represent rough semantics. The foundations of the theory also rely upon the axiomatic approach to granularity for all types of general \textsf{RST} recently developed by the present author. The latter theory is expanded upon in this paper. It is also shown that algebraic semantics of classical \textsf{RST} can be obtained from the developed dialectical counting procedures. Fuzzy set theory is also shown to be representable in purely granule-theoretic terms in the general perspective of solving the contamination problem that pervades this research paper. All this constitutes a radically different approach to the mathematics of vague phenomena and suggests new directions for a more realistic extension of the foundations of mathematics of vagueness from both foundational and application points of view. Algebras corresponding to a concept of \emph{rough naturals} are also studied and variants are characterised in the penultimate section.
description: This paper includes my axiomatic approach to granules. arXiv admin note: substantial text overlap with arXiv:1102.2558
Ext Data File 5 CEACAM6_Transcriptome data_ abundance profiles_Step5b_2022 Sept14
Creators: name: Chaussabel, Damien
Publisher: name: figshare
Year: 2022
Subjects: Biomarkers

description: Extended Data File 5: a spreadsheet in the MS Excel format used to capture CEACAM6 transcriptional profiles from multiple datasets (one dataset per tab) and compute significance of differences in abundance observed between cases and controls).
Trace as an alternative decategorification functor
Creators: name: Beliakova, Anna
name: Guliyev, Zaur
name: Habiro, Kazuo
name: Lauda, Aaron D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Algebra (math.QA)
subject: FOS: Mathematics
subject: 81R50, 17B37, 16E40

description: Categorification is a process of lifting structures to a higher categorical level. The original structure can then be recovered by means of the so-called "decategorification" functor. Algebras are typically categorified to additive categories with additional structure and decategorification is usually given by the (split) Grothendieck group. In this expository article we study an alternative decategorification functor given by the trace or the zeroth Hochschild--Mitchell homology. We show that this form of decategorification endows any 2-representation of the categorified quantum sl(n) with an action of the current algebra U(sl(n)[t]) on its center.
description: 47 pages with tikz figures. arXiv admin note: text overlap with arXiv:1405.5920 by other authors
Planets and Stellar Activity: Hide and Seek in the CoRoT-7 system
Creators: name: Haywood, R. D.
name: Cameron, A. Collier
name: Queloz, D.
name: Barros, S. C. C.
name: Deleuil, M.
name: Fares, R.
name: Gillon, M.
name: Lanza, A. F.
name: Lovis, C.
name: Moutou, C.
name: Pepe, F.
name: Pollacco, D.
name: Santerne, A.
name: Segransan, D.
name: Unruh, Y. C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Since the discovery of the transiting super-Earth CoRoT-7b, several investigations have yielded different results for the number and masses of planets present in the system, mainly owing to the star's high level of activity. We re-observed CoRoT-7 in January 2012 with both HARPS and CoRoT, so that we now have the benefit of simultaneous radial-velocity and photometric data. This allows us to use the off-transit variations in the star's light curve to estimate the radial-velocity variations induced by the suppression of convective blueshift and the flux blocked by starspots. To account for activity-related effects in the radial-velocities which do not have a photometric signature, we also include an additional activity term in the radial-velocity model, which we treat as a Gaussian process with the same covariance properties (and hence the same frequency structure) as the light curve. Our model was incorporated into a Monte Carlo Markov Chain in order to make a precise determination of the orbits of CoRoT-7b and CoRoT-7c. We measure the masses of planets b and c to be 4.73 +/- 0.95 Mearth and 13.56 +/- 1.08 Mearth, respectively. The density of CoRoT-7b is (6.61 +/- 1.72)(Rp/1.58 Rearth)^(-3) g.cm^(-3), which is compatible with a rocky composition. We search for evidence of an additional planet d, identified by previous authors with a period close to 9 days. We are not able to confirm the existence of a planet with this orbital period, which is close to the second harmonic of the stellar rotation at around 7.9 days. Using Bayesian model selection we find that a model with two planets plus activity-induced variations is most favoured.
description: Accepted 2014 July 2. Received 2014 June 30; in original form 2013 May 30 (17 pages, 9 figures)
Modeling of hydrodynamic cavitation reactors: reflections on present status and path forward
Creators: name: Ranade, Vivek
Publisher: name: University of Limerick
Year: 2024
Subjects: classificationCode: 34
subject: Chemical sciences
subject: FOS: Chemical sciences

description: Hydrodynamic cavitation (HC) is finding ever increasing applications in water, energy, chemicals, and materials sectors. HC generates intense shear, localized hot spots, and hydroxyl radicals, which are harnessed for realizing desired physicochemical transformations. Despite identification of HC as one of the most promising technology platforms, its potential is not yet adequately translated in practice. Lack of appropriate models for design, optimization, and scale-up of HC reactors is one of the primary reasons for this. In this work, the current status of modeling of HC reactors is presented. Various prevailing approaches covering empirical, phenomenological, and multiscale models are critically reviewed in light of personal experience of their application. Use of these approaches for different applications such as biomass pretreatment and wastewater treatment is briefly discussed. Some comments on extending these models for other applications like emulsions and crystallization are included. The presented models and discussion will be useful for practicing engineers and scientists interested in applying HC for a variety of applications. Some thoughts on further advances in modeling of HC reactors and outlook are shared, which may stimulate further research on improving the fidelity of computational models of HC reactors.
2-Substitution of Adenine Nucleotide Analogues Containing a Bicyclo[3.1.0]hexane Ring System Locked in a Northern Conformation:  Enhanced Potency as P2Y 1 Receptor Antagonists
Creators: name: Marquez, Victor E.
name: Ohno, Michihiro
name: Harden, T. Kendall
name: Jacobson, Kenneth A.
name: Kim, Hak Sung
name: Choi, Yongseok
name: Maddileti, Savitri
name: Xu, Bin
name: Ji, Xiao D.
name: Kim, Hea Ok
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Preference for the northern (N) ring conformation of the ribose moiety of adenine nucleotide 3′,5′-bisphosphate antagonists of P2Y1 receptors was established by using a ring-constrained methanocarba (a bicyclo[3.1.0]hexane) ring as a ribose substitute (Nandanan et al. J. Med. Chem. 2000, 43, 829–842). We have now combined the ring-constrained (N)-methanocarba modification with other functionalities at the 2-position of the adenine moiety. A new synthetic route to this series of bisphosphate derivatives was introduced, consisting of phosphorylation of the pseudoribose moiety prior to coupling with the adenine base. The activity of the newly synthesized analogues was determined by measuring antagonism of 2-methylthio-ADP-stimulated phospholipase C (PLC) activity in 1321N1 human astrocytoma cells expressing the recombinant human P2Y1 receptor and by using the radiolabeled antagonist [3H]2-chloro-N6-methyl-(N)-methanocarba-2′-deoxyadenosine 3′,5′-bisphosphate 5 in a newly developed binding assay in Sf9 cell membranes. Within the series of 2-halo analogues, the most potent molecule at the hP2Y1 receptor was an (N)-methanocarba N6-methyl-2-iodo analogue 12, which displayed a Ki value in competition for binding of [3H]5 of 0.79 nM and a KB value of 1.74 nM for inhibition of PLC. Thus, 12 is the most potent antagonist selective for the P2Y1 receptor yet reported. The 2-iodo group was substituted with trimethyltin, thus providing a parallel synthetic route for the introduction of an iodo group in this high-affinity antagonist. The (N)-methanocarba-2-methylthio, 2-methylseleno, 2-hexyl, 2-(1-hexenyl), and 2-(1-hexynyl) analogues bound less well, exhibiting micromolar affinity at P2Y1 receptors. An enzymatic method of synthesis of the 3′,5′-bisphosphate from the corresponding 3′-monophosphate, suitable for the preparation of a radiophosphorylated analogue, was explored.
Lahjoita puhetta baseline Kaldi ASR model
Creators: name: Moisio, Anssi
Publisher: name: Zenodo
Year: 2022

description: Lahjoita puhetta baseline speech recognition model, built with the Kaldi toolkit. Trained on 1600 hours of Finnish speech. Described in more detail in the paper https://arxiv.org/abs/2203.12906 "Lahjoita puhetta – a large-scale corpus of spoken Finnish with some benchmarks". For details on the training method, see https://github.com/aalto-speech/lahjoita-puhetta-baseline-kaldi.
title: Fast Dynamic Contrast-enhanced MRI: a novel technique to obtain histopathological information of microvessel density in invasive breast cancer
Creators: name: Mori, Naoko
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Cancer
subject: Comparative studies
subject: MR
subject: Breast

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Microvessel density (MVD) is generally considered to be a measure of new blood vessel formation. MVD is measured by use of CD31—an immunohistochemical marker expressed by vascular endothelial cells. In patients with breast cancer, high MVD is...
Human P2Y 6 Receptor:  Molecular Modeling Leads to the Rational Design of a Novel Agonist Based on a Unique Conformational Preference
Creators: name: Harden, T. Kendall
name: Jacobson, Kenneth A.
name: Marquez, Victor E.
name: Joshi, Bhalchandra V.
name: Mamedova, Liaman
name: Costanzi, Stefano
name: Gonzalez-Moa, Maria J.
name: Maddileti, Savitri
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Combining molecular dynamics (MD) in a hydrated phospholipids (DOPC) bilayer, Monte Carlo search, and synthesis of locked nucleotide analogues we discovered that the Southern conformation of the ribose is preferred for ligand recognition by the P2Y6 receptor. 2′-Deoxy-(S)-methanocarbaUDP was found to be a full agonist of the receptor and displayed a 10-fold higher potency than the corresponding flexible 2′-deoxyUDP. MD results also suggested a conformational change of the second extracellular loop consequent to agonist binding.
Ext Data File 6 CEACAM6_Transcriptome data_diff expression_Step5c_2022 Sept14
Creators: name: Chaussabel, Damien
Publisher: name: figshare
Year: 2022
Subjects: Biomarkers

description: Extended Data File 6: a spreadsheet in the MS Excel format used to capture relevant information regarding differences in CEACAM6 blood transcriptional abundance observed in multiple datasets
Anti-AIDS Agents 69. Moronic Acid and Other Triterpene Derivatives as Novel Potent Anti-HIV Agents
Creators: name: Huang, Li
name: Kashiwada, Yoshiki
name: Yu, Donglei
name: Lee, Kuo-Hsiung
name: Chang, Fang-Rong
name: Chen, Chin-Ho
name: Sakurai, Yojiro
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: In a continuing structure-activity relationship study of potent anti-HIV agents, seven new triterpene derivatives were designed, synthesized, and evaluated for in vitro antiviral activity. Among them, moronic acid derivatives 19, 20 and 21 showed significant activity in HIV-1 infected H9 lymphocytes. Compounds 19 and 20 were also evaluated against HIV-1 NL4−3 and drug resistant strains in the MT-4 cell line. Compounds 19 and 20 showed better antiviral profiles than the betulinic acid analog 8 (PA-457), which has successfully completed a Phase IIa clinical trial. Compound 20 showed potent anti-HIV activity with EC50 values of 0.0085 μM against NL4−3, 0.021 μM against PI-R (a multiple protease inhibitor resistant strain), and 0.13 μM against FHR-2 (an HIV strain resistant to 8), respectively. The promising compound 20 has become a new lead for modification, and further development of 20-related compounds as clinical trial candidates is warranted.
CO map and steep Kennicutt-Schmidt relation in the extended UV disk of M63
Creators: name: Dessauges-Zavadsky, M.
name: Verdugo, C.
name: Combes, F.
name: Pfenniger, D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Results from the UV satellite GALEX revealed large extensions of disks in some nearby spiral galaxies, extending out to 3 to 4 times the isophotal radius, r25. M63 is a remarkable example of a spiral galaxy with one of the most extended UV disks, so it offers the opportunity to search for the molecular gas and characterize the star formation in outer disk regions as revealed by the UV emission. We obtained deep CO(1-0) and CO(2-1) observations on the IRAM 30 m telescope along the major axis of the M63 disk from the center out to the galactocentric radius rgal = 1.6 r25 and over a bright UV region at rgal = 1.36 r25. CO(1-0) is detected all along the M63 major axis out to r25, and CO(2-1) is confined to rgal = 0.68 r25, which may betray lower excitation temperatures in the outer disk. CO(1-0) is also detected in the external bright UV region of M63. The radial profiles of the CO emission and of the Halpha, 24 micron, NUV and FUV star formation tracers and HI taken from the literature show a severe drop with the galactocentric radius, such that beyond r25 they are all absent with the exception of a faint UV emission and HI. The CO emission detection in the external UV region, where the UV flux is higher than the UV flux observed beyond r25, highlights a tight correlation between the CO and UV fluxes, namely the amount of molecular gas and the intensity of star formation. This external UV region is dominated by the atomic gas, suggesting that HI is more likely the precursor of H2 rather than the product of UV photodissociation. A broken power law needs to be invoked to describe the Kennicutt-Schmidt (K-S) relation of M63 from the center of the galaxy out to rgal = 1.36 r25. While all along the major axis out to r25 the K-S relation is almost linear, in the external UV region the SFR regime is highly nonlinear and characterized by a steep K-S relation and very low star formation efficiency.
description: 12 pages, 8 figures, A&A accepted
title: Examination of extremely low dose photographing in tomosynthesis without grid
Creators: name: MASAHIRO, NAKAJIMA
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Kv imaging
subject: Screening
subject: Imaging sequences
subject: Dosimetry
subject: Digital radiography
subject: Lung

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Back grand Currently, tomosynthesis of digital tomography system continues to evolve through the development of FPD (flat panel detector). The chest tomosynthesis imaging has a smaller Exposure dose than the Computed Tomography (CT) and the...
title: Numerical methods for the solution of fractional differential equations
Creators: name: Charles. Simpson, Arthur
Publisher: name: University of Liverpool Repository
Year: 2023

description: The fractional calculus is a generalisation of the calculus of Newton and Leibniz. The substitution of fractional differential operators in ordinary differential equations substantially increases their modelling power. Fractional differential operators set exciting new challenges to the computational mathematician because the computational cost of approximating fractional differential operators is of a much higher order than that necessary for approximating the operators of classical calculus. 1. We present a new formulation of the fractional integral. 2. We use this to develop a new method for reducing the computational cost of approximating the solution of a fractional differential equation. 3. This method can be implemented with two levels of sophistication. We compare their rates of convergence, their algorithmic complexity, and their weight set sizes so that an optimal choice, for a particular application, can be made. 4. We show how linear multiterm fractional differential equations can be approximated as systems of fractional differential equations of order at most 1.
Antitumor Agents. 250. † Design and Synthesis of New Curcumin Analogues as Potential Anti-Prostate Cancer Agents
Creators: name: Nyarko, Alexander K.
name: Lee, Kuo-Hsiung
name: Lin, Li
name: Shih, Charles C.-Y
name: Bastow, Kenneth F.
name: Wu, Chin-Chung
name: Shi, Qian
name: Su, Ching-Yuan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: In a continuing study of curcumin analogs as potential drug candidates to treat prostate cancer at both androgen-dependent and androgen-refractory stages, we designed and synthesized over 40 new analogs classified into four series: monophenyl analogs (series A), heterocycle-containing analogs (series B), analogs bearing various substituents on the phenyl rings (series C) and analogs with various linkers (series D). These new compounds were tested for cytotoxicity against two human prostate cancer cell lines, androgen-dependent LNCaP and androgen-independent PC-3. Antiandrogenic activity was also evaluated in LNCaP cells and PC-3 cells transfected with wild-type androgen receptor. Ten compounds possessed potent cytotoxicity against both LNCaP and PC-3 cells; seven only against LNCaP; and one solely against PC-3. This study established an advanced structure-activity relationship (SAR), and these correlations will guide the further design of new curcumin analogs with better anti-prostate cancer activity.