Characteristics and laboratory findings on admission to the emergency department among 2873 hospitalized patients with COVID-19: the impact of adjusted laboratory tests in multicenter studies. A multicenter study in Spain (BIOCOVID-Spain study)
Creators: name: De Guadiana-Romualdo, Luis García
name: Morell-García, Daniel
name: Morales-Indiano, Cristian
name: Bauça, Josep Miquel
name: Martín, María José Alcaide
name: Valle, Clara Esparza Del
name: Revilla, Jose I. Gutiérrez
name: Urrechaga, Eloisa
name: Álamo, José M.
name: Holgado, Ana M. Hernando
name: María-Carmen Lorenzo-Lozano
name: Fdez-Pacheco, Silvia Sánchez
name: De La Hera Cagigal, Patricia
name: Tobarra, María A. Juncos
name: Vílchez, Juan A.
name: Chamorro, Isabel Vírseda
name: Garcia, Irene Gutiérrez
name: Yolanda Pastor Murcia
name: Frías, Laura Sahuquillo
name: Queral, Laura Altimira
name: Nuez-Zaragoza, Elisa
name: De León, Juan Adell Ruiz
name: Ripa, Alicia Ruiz
name: Gómez-Pablos, Paloma Salas
name: López, Iria Cebreiros
name: Uriarte, Amaia Fernández
name: Álex Larruzea
name: Yepes, María L. López
name: Torrella, Patricia Esteban
name: Andrés, María C. Zamorano
name: Díaz, Jose Pedregosa
name: Alcaraz, Cristina Acevedo
name: Alfonso-L. Blazquez-Manzanera
name: Jiménez, Ana M. L. Padilla
name: Calzada, María C. Baamonde
name: Vera, Marina
name: Rudilla, Matilde Cháfer
name: Campás, Magdalena Canalda
name: Muñoz, Sara García
name: Gutiérrez, Luis Vicente
name: Añón, Laura Jiménez
name: Martínez, Alfonso Pérez
name: Castillo, Aurelio Pons
name: Tamayo, Ruth González
name: Vivancos, Jorge Férriz
name: Olaia Rodríguez-Fraga
name: De Brito Fernández, Vicente Ferrer Díaz
name: Aguadero, Vicente
name: Arévalo, María G. García
name: Carrillo, María Arnaldos
name: Morales, Mercedes González
name: Gárate, María Núñez
name: Iruela, Cristina Ruiz
name: Sancho-Rodríguez, Natalia
name: Pérez, Marti Vila
name: Egea-Caparrós, José M.
name: Sáenz, Luis
name: Barbero, Álvaro Blasco
name: Ortega, Amparo Galán
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: FOS: Biological sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: FOS: Health sciences

description: Identification of predictors for severe disease progression is key for risk stratification in COVID-19 patients. We aimed to describe the main characteristics and identify the early predictors for severe outcomes among hospitalized patients with COVID-19 in Spain. This was an observational, retrospective cohort study (BIOCOVID-Spain study) including COVID-19 patients admitted to 32 Spanish hospitals. Demographics, comorbidities and laboratory tests were collected. Outcome was in-hospital mortality. For analysis, laboratory tests values were previously adjusted to assure the comparability of results among participants. Cox regression was performed to identify predictors. Study population included 2873 hospitalized COVID-19 patients. Nine variables were independent predictors for in-hospital mortality, including creatinine (Hazard ratio [HR]:1.327; 95% Confidence Interval [CI]: 1.040-1.695, <i>p</i> = .023), troponin (HR: 2.150; 95% CI: 1.155-4.001; <i>p</i> = .016), platelet count (HR: 0.994; 95% CI: 0.989-0.998; <i>p</i> = .004) and C-reactive protein (HR: 1.037; 95% CI: 1.006-1.068; <i>p</i> = .019). This is the first multicenter study in which an effort was carried out to adjust the results of laboratory tests measured with different methodologies to guarantee their comparability. We reported a comprehensive information about characteristics in a large cohort of hospitalized COVID-19 patients, focusing on the analytical features. Our findings may help to identify patients early at a higher risk for an adverse outcome.