cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Regulation of energy metabolism during early B lymphocyte development
Creators: name: Urbanczyk, Sophia
name: Stein, Merle
name: Schuh, Wolfgang
name: Jäck, Hans-Martin
name: Mougiakakos, Dimitrios
name: Mielenz, Dirk Alexander
Publisher: name: Universität Ulm
Year: 2018
Subjects: subject: B lymphocyte development
subject: EFhd1
subject: pre-BCR
subject: mitoflash
subject: oxidative phosphorylation
subject: DDC 570 / Life sciences
subject: Metabolism
subject: Mitochondria
subject: Glycolysis
subject: Stoffwechsel
subject: Mitochondrium
subject: Glykolyse

description: he most important feature of humoral immunity is the adaptation of the diversity of newly generated B cell receptors, that is, the antigen receptor repertoire, to the body’s own and foreign structures. This includes the transient propagation of B progenitor cells and B cells, which possess receptors that are positively selected via anabolic signalling pathways under highly competitive conditions. The metabolic regulation of early B-cell development thus has important consequences for the expansion of normal or malignant pre-B cell clones. In addition, cellular senescence programs based on the expression of B cell identity factors, such as Pax5, act to prevent excessive proliferation and cellular deviation. Here, we review the basic mechanisms underlying the regulation of glycolysis and oxidative phosphorylation during early B cell development in bone marrow. We focus on the regulation of glycolysis and mitochondrial oxidative phosphorylation at the transition from non-transformed pro- to pre-B cells and discuss some ongoing issues. We introduce Swiprosin-2/EFhd1 as a potential regulator of glycolysis in pro-B cells that has also been linked to Ca2+-mediated mitoflashes. Mitoflashes are bioenergetic mitochondrial events that control mitochondrial metabolism and signalling in both healthy and disease states. We discuss how Ca2+ fluctuations in pro- and pre-B cells may translate into mitoflashes in early B cells and speculate about the consequences of these changes.
Paper Review Course Vii: Self Assembly Of Polyoxometalate Clusters
Creators: name: Wihadi, Muh. Nur Khoiru
Publisher: name: Zenodo
Year: 2018

description: Cronin group reported novel polyoxometalate clusters using a self-sorting approach. The building blocks self-assembled into cross-shaped clusters architectures as intended, leading the collection of mixed Heteroanions (HAs) incorporated into the cross-shaped Heteropolyanions (HPAs) [(XYW15O54)4(WO2)4]32−/36− (X = H−P, Y = Se, Te, As).
ΔMST and the regulation of cardiac CSE and OTR expression in trauma and hemorrhage
Creators: name: Trautwein, Britta
name: Merz, Tamara
name: Denoix, Nicole
name: Szabo, Csaba
name: Calzia, Enrico
name: Radermacher, Peter
name: McCook, Oscar
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: early life stress
subject: DDC 570 / Life sciences
subject: DDC 610 / Medicine & health
subject: Hydrogen sulfide
subject: Mitochondria
subject: Receptors, Oxytocin
subject: Schwefelwasserstoff
subject: Mitochondrium
subject: Oxytocin

description: Genetic deletion of 3-mercaptopyruvate sulfurtransferase (MST) is known to result in hypertension and cardiac hypertrophy in older mice, and is associated with increased anxiety-like behaviors. Endogenous hydrogen sulfide (H2S) produced by MST in the mitochondria is also known to be involved in physiological and cellular bioenergetics, and its dysfunction associated with depressive behavior and increased cardiovascular morbidity. Interestingly, early life stress has been shown to lead to a significant loss of cystathionine-γ-lyase (CSE) and oxytocin receptor (OTR) expression in the heart. Thus, we were interested in testing the hypothesis of whether genetic MST mutation (ΔMST) would affect cardiac CSE and OTR expression and affect the mitochondrial respiration in a clinically relevant, resuscitated, mouse model of trauma and hemorrhagic shock. In ΔMST mice, we found a reduction of CSE and OTR in both the naive as well as injured state, in contrast to the wild type (wt) controls. Interestingly, the ΔMST showed a different complex IV response to injury than the wt controls, although our claims are based on the non-demonstrated assumption that naive wt and naive ΔMST mice have comparable complex IV activity. Finally, hemorrhagic shock led to a reduction of CSE and OTR, confirming previous results in the injured mouse heart. To date, the exact mechanisms of the cardiac interaction between H2S and OT are not clear, but they point the way to potential cardioprotective therapies.
sj-docx-1-mso-10.1177_20552173221132170 - Supplemental material for Quantitative spinal cord MRI and sexual dysfunction in multiple sclerosis
Creators: name: Seyman, Estelle
name: Kim, David
name: Bharatha, Aditya
name: Casserly, Courtney
name: Krysko, Kristen
name: Chantal, Roy-Hewitson
name: Alcaide-Leon, Paula
name: Suthiphosuwan, Suradech
name: Oh, Jiwon
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Neuroscience

description: Supplemental material, sj-docx-1-mso-10.1177_20552173221132170 for Quantitative spinal cord MRI and sexual dysfunction in multiple sclerosis by Estelle Seyman, David Kim, Aditya Bharatha, Courtney Casserly, Kristen Krysko, Roy-Hewitson Chantal, Paula Alcaide-Leon, Suradech Suthiphosuwan and Jiwon Oh in Multiple Sclerosis Journal – Experimental, Translational and Clinical
Additional file 1 of Community-based surveillance programme evaluation using the platform Nyss implemented by the Somali Red Crescent Society—a mixed methods approach
Creators: name: Jung, Julia
name: Larsen, Tine Mejdell
name: Beledi, Abdifatah Hussein
name: Takahashi, Emi
name: Ahmed, Abdirahman Omer
name: Reid, Jenny
name: Kongelf, Ida Anine
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Supplementary Material 1
title: Die Rolle der Königin im 9. Jahrhundert
Creators: name: Drucker, Agnes
Year: 2009

description: Die vorliegende Arbeit beschäftigt sich mit der politischen Rolle der Königin im 9. Jahrhundert, wobei speziell die Situation im Frankenreich, beginnend mit der Zeit Ludwig des Frommen bis hin zu Arnulf von Kärnten, beleuchtet wird. Um die Verhältnisse im Frankenreich in Perspektive zu setzen, widmet sich ein zweiter, kürzerer Teil, dem westsächsischen Königreich. Anhand der Analyse verschiedener Aspekte wird versucht, sich der politischen Rolle der Königin hauptsächlich im Frankenreich anzunähern und abzuklären, inwiefern diese Handlungsspielraum gewinnen konnte. Die Arbeit mündet schließlich in die Darstellung bei den Westsachsen, wobei methodisch anhand eines Vergleichs vorgegangen wird. Die vordergründige Fragestellung lautet dabei: Wie konnte die Königin politische Macht erreichen? Welchen Status konnte eine Königin innerhalb Kontinentaleuropas und schließlich auch im angelsächsischen England im 9. Jahrhundert erreichen? Es wurden breit gefächerte Aspekte gewählt, um den möglichen politischen Handlungsspielraum und das politische Wirken der Königin aufzeigen zu können. Die Analyse beginnt bei der Auseinandersetzung mit der (hoch-)adeligen Herkunft der Königin vor dem Hintergrund machtpolitischer Auseinandersetzungen und bei deren dos, durch welche die überhaupt die Gattin des Herrschers erst rechtmäßig als solche gelten konnte. Titel und Krönungen waren Symbole, durch die die Herrscherin einen erhöhten Status- teilweise jenem des Herrschers gleich- erreichen konnte. Wirkungsweisen der Königin, wie etwa ihre Aufgaben am Königshof, ihre Reisetätigkeit und vor allem Interventionen in Urkunden zeigen weiters ihren Handlungsspielraum auf. Der Kreis wird durch die Betrachtung des letzten Lebensabschnitts der Königin, der Witwenschaft beziehungsweise des Tods geschlossen. In der Folge werden die westsächsischen Königinnen nach den eben vorgestellten Aspekten untersucht. Dabei wird die Situation der Königin bei den Franken mit jener bei den Westsachsen verglichen.
sj-pdf-3-obm-10.1177_1753495X221133150 - Supplemental material for Maternal health and pregnancy outcomes in autosomal dominant tubulointerstitial kidney disease
Creators: name: Bleyer, Anthony J
name: Kidd, Kendrah O
name: Williams, Adrienne H
name: Johnson, Emily
name: Robins, Victoria
name: Martin, Lauren
name: Taylor, Abbigail
name: Kim, Alice
name: Bowline, Isai
name: Connaughton, Dervla M
name: Langefeld, Carl D
name: Zivna, Martina
name: Kmoch, Stanislav
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 111402 Obstetrics and Gynaecology
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-3-obm-10.1177_1753495X221133150 for Maternal health and pregnancy outcomes in autosomal dominant tubulointerstitial kidney disease by Anthony J Bleyer, Kendrah O Kidd, Adrienne H Williams, Emily Johnson, Victoria Robins, Lauren Martin, Abbigail Taylor, Alice Kim, Isai Bowline, Dervla M Connaughton, Carl D Langefeld, Martina Zivna and Stanislav Kmoch in Obstetric Medicine
Additional file 2 of Community-based surveillance programme evaluation using the platform Nyss implemented by the Somali Red Crescent Society—a mixed methods approach
Creators: name: Jung, Julia
name: Larsen, Tine Mejdell
name: Beledi, Abdifatah Hussein
name: Takahashi, Emi
name: Ahmed, Abdirahman Omer
name: Reid, Jenny
name: Kongelf, Ida Anine
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Supplementary Material 2
sj-doc-6-ltr-10.1177_13621688221127643 – Supplemental material for The effects of direct written corrective feedback and comparator texts on the complexity and accuracy of revisions and new pieces of writing
Creators: name: Hamano-Bunce, Douglas
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: Education
subject: 200399 Language Studies not elsewhere classified
subject: FOS: Languages and literature

description: Supplemental material, sj-doc-6-ltr-10.1177_13621688221127643 for The effects of direct written corrective feedback and comparator texts on the complexity and accuracy of revisions and new pieces of writing by Douglas Hamano-Bunce in Language Teaching Research
Supplemental Material - Changes in Harm Perception for E-Cigarettes Among Youth in the United States, 2014–2019
Creators: name: Namwase, Angella Sandra
name: Gyimah, Emmanuel A.
name: Carothers, Bobbi J.
name: Combs, Todd B.
name: Harris, Jenine K.
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental Material for Changes in Harm Perception for E-Cigarettes Among Youth in the United States, 2014–2019 by Angella Sandra Namwase, Emmanuel A. Gyimah, Bobbi J. Carothers, Todd B. Combs, and Jenine K. Harris in American Journal of Health Promotion
Data for: Risky business: Males choose more receptive adults over safer subadults in a cannibalistic spider
Creators: name: Scott, Catherine
name: Sentenská, Lenka
name: Mouginot, Pierick
name: Andrade, Maydianne
Publisher: name: Zenodo
Year: 2022

description: Understanding factors affecting male mate choice can be important for tracking the dynamics of sexual selection in nature. Contextual variation in reproductive costs and benefits of different types of mates may predict male choice, but mating may also be opportunistic regardless of female reproductive value. Male brown widow spiders (Latrodectus geometricus) can mate with adult as well as immature (subadult) females. Matings with adults require costly courtship and typically end with cannibalism ('self-sacrifice' initiated by a male somersault), but matings with subadults involve more brief courtship and no risk of cannibalism. We examined whether there was evidence for male mate choice as a function of risks associated with different types of mates and the cues available to courting males. Previous studies showed male preference for adult females based on airborne pheromones. In our study, males preferred adult females based on silk-borne contact cues. We swapped adult and subadult females between webs to determine which cues trigger different components of courtship, and showed that contact with adult females' webs triggers web reduction and contact with adult females' bodies triggers mate binding and somersaulting, but vibratory courtship occurs regardless of the origin of the web or female developmental stage. We conclude that males can detect and recognize subadult females as potential mating partners, but are more likely to invest in costly courtship behaviours and mating attempts with adults. In our experiments, subadult females were less likely to mate than adults. We conclude that mating with adults could be the preferred option for males because of the higher likelihood of copulation, even at the cost of a higher risk of cannibalism.
description: Data were collected in two laboratory experiments: 1) Male responses to subadult vs. adult female silk cues in a Y-maze 2-choice experiment 2) Outcomes of mating trials in which males courted subadult or adult females placed on the webs of other females in a fully crossed design All analyses were conducted in R version 4.0.0. See paper for full details of experimental design and analysis.
Jahresbericht der Universität Ulm 2009
Creators: name: (:Unkn) Unknown
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: DDC 050 / General serial publications
subject: Research; Ulm
subject: Universities; Germany; Ulm
subject: Forschungsbericht
subject: Ulm / Universität

description: Jahresbericht der Universität Ulm 2009 in deutscher und englischer Sprache
Additional file 3 of Community-based surveillance programme evaluation using the platform Nyss implemented by the Somali Red Crescent Society—a mixed methods approach
Creators: name: Jung, Julia
name: Larsen, Tine Mejdell
name: Beledi, Abdifatah Hussein
name: Takahashi, Emi
name: Ahmed, Abdirahman Omer
name: Reid, Jenny
name: Kongelf, Ida Anine
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Supplementary Material 3
Die Chance Der Prävention In Bezug Auf Das Phänomen Der Trink-Fahr-Problematik: Eine Empirische Untersuchung Der Prävalenz Von Alkoholproblemen Bei Erst-Fiaz-Teilnehmenden Sowie Eine Fiaz-Kursevaluation In Den Kantonen Schwyz Und Uri
Creators: name: Kurmann, Evelyne
name: Zwyssig-Inderbitzin, Simone
Publisher: name: Zenodo
Year: 2011
Subjects: subject: gnd:4055676-1
subject: gnd:4001223-2
subject: gnd:4057931-1
subject: gnd:4076308-0

description: Die Trink-Fahr-Problematik hat im Verlaufe der letzten Jahrzehnte stetig zugenommen und ist bis zum heutigen Zeitpunkt weit verbreitet. Alkoholkonsum hat in der Schweiz einen hohen Stellenwert und gilt als gesellschaftliches «Schmiermittel». Das Lenken eines Motorfahrzeugs ist für die Mehrheit der Schweizer Bevölkerung kaum mehr aus dem Alltag wegzudenken. In Verbindung mit dem Alkoholkonsum treten jedoch erhebliche Gefahren im Strassenverkehr auf, die schwerwiegende Folgen nach sich ziehen können. Die Bachelor-Arbeit befasst sich mit dieser Problematik und hat zum Ziel, die Chance der Prävention in Bezug auf das Fahren in angetrunkenem Zustand (FiaZ) zu beleuchten. Hierfür bestimmen die Autorinnen mittels einer quantitativen Forschung die Untergruppen mit ihren spezifischen Trink- und Verhaltensmustern in den Erst-FiaZ-Kursen. Das Ziel ist, eine Prävalenz von risikohaftem Alkoholkonsum bei Erst-FiaZ-Teilnehmenden zu bestimmen. Zudem evaluieren die Autorinnen anhand einer qualitativen Forschung die Erst-FiaZ-Kurse in den Kantonen Schwyz und Uri. Die Bachelor-Arbeit zeigt auf, dass eine Mehrheit der Erst-FiaZ-Delinquenten einen riskanten Alkoholkonsum aufweist. Die Soziale Arbeit nützt anhand der Erst-FiaZ-Kurse bereits ihre Chance und begegnet der Trink-Fahr-Problematik durch Rückfallprävention. Diese verfolgt das Ziel, Trinken und Fahren zu trennen. Um das Bewusstsein der Trink-Fahr-Problematik bei der Bevölkerung zu verstärken, ist es wichtig, dass die Soziale Arbeit den Diskurs darüber in der Öffentlichkeit fördert.
description: + Code Diss LU: hslusa basa 2011 be + Fussnote: Bachelor-Arbeit, Hochschule Luzern - Soziale Arbeit, Ausbildungsgang Sozialarbeit, 2011
sj-pdf-1-mde-10.1177_23821205231217894 - Supplemental material for Qualitative Findings of a Nominal Group Process to Identify Critical Factors in New LIC Implementation
Creators: name: Eddings, Stacy K.
name: Brown, Laura L.
name: Godin, Steven
Publisher: name: SAGE Journals
Year: 2023
Subjects: Education

description: Supplemental material, sj-pdf-1-mde-10.1177_23821205231217894 for Qualitative Findings of a Nominal Group Process to Identify Critical Factors in New LIC Implementation by Stacy K. Eddings, Laura L. Brown and Steven Godin in Journal of Medical Education and Curricular Development
title: "si suln bêde schamec sîn, juncherre unde vröuwelîn"
Creators: name: Kollmann, Stefanie
Year: 2009

description: Diese Diplomarbeit beschäftigt sich mit dem Schamgefühl im Mittelalter. Nach einigen Erläuterungen zum aktuellen Forschungsgebiet der historischen Emotionsforschung, wurden die verschiedenen literarischen und geistlichen Quellen auf Situationen im Text untersucht, in denen Personen die Emotion Scham empfinden. Um die unterschiedlichen Situationen und Textstellen vergleichbar zu machen, wurde ein Analyseraster von zwölf verschiedenen Genres entwickelt, in welche die einzelnen Situationen der Scham eingeordnet wurden. Die zwölf Genres umfassen wesentliche Aspekte des mittelalterlichen Lebens, der höfischen Literatur und Kultur und der weltlichen und religiösen Normen und Vorstellungen, die in Verbindung mit dem Schamgefühl stehen, sowie wichtige Gesichtspunkte der Theorien zum Schamgefühl.
"And now I have male privilege": transgender accounts of the precarity of privilege
Creators: name: Beck, Armani
Publisher: name: No Publisher Supplied
Year: 2024

description: This common and current conceptualization of male privilege implies that men are privileged as a result of being men and that women are disadvantaged as a result of being women, and that this binary classification is absolute. This is largely true- there are gender-based advantages that women (and those perceived as women) simply do not benefit from. However, what happens when the privileges associated with masculinity conflict with the disadvantages associated with Blackness, with queerness, with neurodivergence, and even with height? Is male privilege about the personal, the biological, or the social, and does the answer to that question leave room for women and other genders to also have male privilege? Through in-depth interviews with transgender people who have experience being perceived on both sides of the gender binary I draw patterns across who has access to male privilege, whether privilege is fixed or dynamic, and the sociomental and intersubjective process of assigning privilege, particularly when there are socially incompatible characteristics. I find that male privilege can be gained, lost, and maintained, that the degree of male privilege one benefits from is dependent on visible or assumable characteristics that conflict with Western hegemonic masculinity, and that domination works both internally (men having privilege relative to other men) and externally (men having privilege relative to other genders).
sj-docx-5-mde-10.1177_23821205231221950 - Supplemental material for Interprofessional Active Learning for Chronic Pain: Transforming Student Learning From Recall to Application
Creators: name: Helms, Jeb
name: Frankart, Laura
name: Bradner, Melissa
name: Ebersole, Jonathan
name: Regan, Beck
name: Crouch, Taylor
Publisher: name: SAGE Journals
Year: 2023
Subjects: Education

description: Supplemental material, sj-docx-5-mde-10.1177_23821205231221950 for Interprofessional Active Learning for Chronic Pain: Transforming Student Learning From Recall to Application by Jeb Helms, Laura Frankart, Melissa Bradner, Jonathan Ebersole, Beck Regan and Taylor Crouch in Journal of Medical Education and Curricular Development
On the correspondence between neural folding architectures and tree automata
Creators: name: Küchler, Andreas
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: DDC 004 / Data processing & computer science
subject: Computer architecture
subject: Neural computers
subject: Neuronales Netz

description: The folding architecture together with adequate supervised training algorithms is a special recurrent neural network model designed to solve inductive inference tasks on structured domains. Recently, the generic architecture has been proven as a universal approximator of mappings from rooted labeled ordered trees to real vector spaces. In this article we explore formal correspondences to the automata theory in order to characterize the representational capabilities of different instances of the generic folding architecture. As the main result we prove that simple instances of the folding architecture have the computational power of at least the class of deterministic bottom-up tree automata. All proofs are carried out in a constructive manner and a detailed analysis of the space complexity of the construction schemes is provided. We derive bounds for the principled node complexity of folding architecture implementations of tree automata. The possible embedding of the neural folding architecture into a general knowledge-injection-refinement-extraction framework is briefly discussed.
Additional file 4 of Community-based surveillance programme evaluation using the platform Nyss implemented by the Somali Red Crescent Society—a mixed methods approach
Creators: name: Jung, Julia
name: Larsen, Tine Mejdell
name: Beledi, Abdifatah Hussein
name: Takahashi, Emi
name: Ahmed, Abdirahman Omer
name: Reid, Jenny
name: Kongelf, Ida Anine
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Supplementary Material 4
title: Kontrollierte Kreativität
Creators: name: Bartsch, Eva Katharina
Year: 2009

description: Die ungewöhnliche Vielzahl an Zeichnungen, besonders die Detailzeichnungen, die Barocci der Nachwelt hinterließ, deuteten eine Sonderstellung in der damaligen Kunstauffassung an. Obwohl, wie sich herausstellte, alle heute erhaltenen größeren Sammlungen einen ungeordneten Zustand offen legen, schienen dennoch alle Zeichnungen in einem bestimmten Zusammenhang zueinander zu stehen, den es zu ergründen galt. Die Frage nach einem systematisch angewendeten Konzept, das sich in den Zeichnungen verbirgt, wurde an den ca. 400 Zeichnungen des Berliner Kupferstichkabinetts eingehender untersucht. Analysen der von Barocci verwendeten Trägermaterialien, der Zeichenmaterialien, wie auch die eingehende Sichtung aller Zeichnungen bestätigte die Existenz dieses Konzeptes. In Form einer Retrospektive wurde hierfür der detaillierte Entstehungsprozess der Bildthemen „Madonna del Popolo“ und der „Heimsuchung“ nachvollzogen und ermöglichte neue Einblicke in die konstruktive Vorgehensweise bei der Bilderstellung. Zeichnungen aus anderen Sammlungen wurden zur Schließung offener Lücken herangezogen.
Genomic basis for skin phenotype and cold adaptation in the extinct Steller's sea cow
Creators: name: Le Duc, Diana
name: Velluva, Akhil
name: Cassatt-Johnstone, Molly
name: Olsen, Remi-Andre
name: Baleka, Sina
name: Lin, Chen-Ching
name: R. Lemke, Johannes
name: R. Southon, John
name: Burdin, Alexander
name: Wang, Ming-Shan
name: Grunewald, Sonja
name: Rosendahl, Wilfried
name: Joger, Ulrich
name: Rutschmann, Sereina
name: B. Hildebrandt, Thomas
name: Fritsch, Guido
name: A. Estes, James
name: Kelso, Janet
name: Dalén, Love
name: Hofreiter, Michael
name: Shapiro, Beth
name: Schöneberg, Torsten
Publisher: name: Zenodo
Year: 2021

description: Steller's sea cow, an extinct sirenian and one of the largest Quaternary mammals, was described by Georg Steller in 1741 and eradicated by humans within 27 years. Here, we complement Steller's descriptions with paleogenomic data from 12 individuals. We identified convergent evolution between Steller's sea cow and cetaceans but not extant sirenians, suggesting a role of several genes in adaptation to cold environments. Among these are inactivations of lipoxygenase genes, which in humans and mouse models cause ichthyosis – a skin disease characterized by a thick, hyperkeratotic epidermis that recapitulates Steller's sea cows' reportedly bark-like skin. Finally, we found that Steller's sea cows' abundance was continuously declining for tens of thousands of years prior to their description, implying that environmental changes also contributed to their extinction.
description: We extracted ancient DNA from fragmentary remains of 12 Steller's sea cow individuals recovered from beaches of Bering Island, which we radiocarbon dated to 2205–1155 BP. We sequenced the genomes of two of the best preserved of these (SNMB N51667 from the Braunschweig Natural History Museum and SC16.JK045 from the collection of the Kamchatka Branch of the Pacific Geographical Institute, RAS Museum) to 15.86 and 15.63× coverage, respectively, and the remaining ten to an average coverage of 2.78× (range 1.97–3.95×).
Orientações para os acompanhantes: Transmissão de infecções hospitalares por via cruzada
Creators: name: Juliana Garcia de Mello
name: Pedro Ruiz Barbosa Nassar
Publisher: name: Zenodo
Year: 2024
Subjects: Acompanhantes
Hospital
Segurança do paciente
Infecções
Orientações

description: O produto trata-se de um material escrito, criado como tecnologia auxiliar da educação em saúde, para o ambiente hospitalar. Tem como objetivo fornecer orientações ao público-alvo, que são os acompanhantes no processo de internação, sobre comportamentos de riscos, realizados pelos mesmos, que podem vir a ser meios de transmissão de infecções hospitalares por via cruzada, principalmente por contato. Assim, esse material tem intenção de atrair o engajamento de pacientes e seus familiares para uma temática tão relevante, que é a redução e melhoria dos indicadores em saúde referentes as infecções hospitalares, contribuindo, portanto, para o processo de internação segura.
Additional file 5 of Community-based surveillance programme evaluation using the platform Nyss implemented by the Somali Red Crescent Society—a mixed methods approach
Creators: name: Jung, Julia
name: Larsen, Tine Mejdell
name: Beledi, Abdifatah Hussein
name: Takahashi, Emi
name: Ahmed, Abdirahman Omer
name: Reid, Jenny
name: Kongelf, Ida Anine
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Supplementary Material 5
Patient-reported prevalence of non-motor symptoms is low in adult patients suffering from 5q Spinal Muscular Atrophy
Creators: name: Günther, René
name: Wurster, Claudia Diana
name: Cordts, Isabell
name: Koch, Jan Christoph
name: Kamm, Christoph
name: Petzold, Daniel
name: Aust, Elisa
name: Deschauer, Marcus
name: Lingor, Paul
name: Ludolph, Albert Christian
name: Hermann, Andreas
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: spinal muscular atrophy (SMA)
subject: motor neuron disease (MND)
subject: multisystem disorder
subject: non-motor symptoms
subject: NMSQuest
subject: PARKINSONS-DISEASE
subject: MOTOR
subject: VULNERABILITY
subject: MODEL
subject: DDC 610 / Medicine & health
subject: Muscular atrophy, Spinal
subject: Parkinson disease
subject: Motor neuron disease
subject: Motor neurons
subject: Spinale Muskelatrophie
subject: Parkinson-Krankheit
subject: Motoneuron

description: Background: 5q spinal muscular atrophy (SMA) is an autosomal recessive lower motoneuron disease caused by deletion or mutations in the survival motor neuron 1 gene (SMN1) which results in reduced expression of full-length SMN protein. The main symptoms are caused by spinal motor neuron demise leading to muscle atrophy, and medical care mostly refers to motor symptoms. However, new insights of recent studies in severe SMA type I revealed disease involvement of several non-motor regions, for example cardiac, vascular, sensory nerve involvement, and thalamic lesions. Non-motor symptoms (NMS) were previously described in many neurodegenerative diseases i.e., Parkinson's disease and, importantly, also amyotrophic lateral sclerosis. Methods: We screened for NMS in 70 adult patients with SMA type II (SMAII) and type III (SMAIII) and 59 age/sex-matched healthy controls (controls) in a multicenter cross-sectional study including 5 different centers with specialized expertise in medical health care of motoneuron diseases. We used a self-rating questionnaire including 30 different items of gastrointestinal, autonomic, neuropsychiatric, and sleep complaints [NMS questionnaire (NMSQuest)], which is a validated tool in Parkinson's disease. Results: Total NMS burden was low in adult SMA (median: 3 items) and not significantly different compared to controls (median: 2 items). Total NMS of SMA patients did not correlate with disease severity scores. However, the items “swallowing difficulties,” “falling,” and particularly “swelling legs” were significantly more frequently reported in SMA. Neuropsychiatric symptoms were reported in a frequency comparable to controls and were not significantly increased in SMA. Conclusion: Patient-reported prevalence of NMS in adult SMA was low, which does not argue for a clinically relevant multisystemic disorder in SMAII/III. Importantly, adult SMA patients do not seem to suffer more frequently from symptoms of depression or adaptive disorders compared to controls. Our results yield novel information on previously underreported symptoms and will help to improve the medical guidance of these patients.
Additional file 1 of Impact of a multidisciplinary management team on clinical outcome in ICU patients affected by Gram-negative bloodstream infections: a pre-post quasi-experimental study
Creators: name: Rinaldi, Matteo
name: Gatti, Milo
name: Tonetti, Tommaso
name: Nocera, Domenico
name: Ambretti, Simone
name: Berlingeri, Andrea
name: Nigrisoli, Giacomo
name: Pierucci, Elisabetta
name: Siniscalchi, Antonio
name: Pea, Federico
name: Viale, Pierluigi
name: Giannella, Maddalena
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Supplementary Material 1: Study flow chart
A generalized model for two-element biomimetic antenna arrays
Creators: name: Grüner, Patrik
name: Chaloun, Tobias
name: Waldschmidt, Christian
Publisher: name: Universität Ulm
Year: 2018
Subjects: subject: Biomimetic antenna arrays
subject: Antenna arrays
subject: Biologically-inspired antennas
subject: Direction-of-arrival (DoA) estimation
subject: DDC 620 / Engineering & allied operations
subject: Biomimetics
subject: Antennas (Electronics); Research
subject: Bionik
subject: Antennengruppe

description: Biomimetic Antenna Arrays (BMAAs) are antenna systems enabling an improved angle estimation for small apertures by mimicking the hearing system of the fly Ormia ochracea. This is achieved by a special kind of coupling applied to the antenna elements inspired by the insect. However, recent designs of BMAAs rely on a strong mutual coupling between the antenna elements. In this paper, it will be shown that the strong mutual coupling is not needed for a BMAA at the antenna side, and a generalized model of the biomimetic antenna system is theoretically derived, evaluated, and verified by measurements. This new model also gives an intuitive insight into the working principle of the biomimetic antenna system.
Additional file 2 of Impact of a multidisciplinary management team on clinical outcome in ICU patients affected by Gram-negative bloodstream infections: a pre-post quasi-experimental study
Creators: name: Rinaldi, Matteo
name: Gatti, Milo
name: Tonetti, Tommaso
name: Nocera, Domenico
name: Ambretti, Simone
name: Berlingeri, Andrea
name: Nigrisoli, Giacomo
name: Pierucci, Elisabetta
name: Siniscalchi, Antonio
name: Pea, Federico
name: Viale, Pierluigi
name: Giannella, Maddalena
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Supplementary Material 2: Supplementary tables E1 and E2
sj-docx-2-nmi-10.1177_11786388221125181 – Supplemental material for Metabolic and Anthropometric Parameters of Persons at Risk of Developing Type 2 Diabetes Mellitus Before and After 3 Months of Consuming Insoluble Dietary Fiber
Creators: name: Khalangot, Mykola D
name: Gurianov, Vitaly G
name: Zakharchenko, Tamara F
name: Pysarenko, Yurii M
name: Kravchenko, Victor I
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 111199 Nutrition and Dietetics not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, sj-docx-2-nmi-10.1177_11786388221125181 for Metabolic and Anthropometric Parameters of Persons at Risk of Developing Type 2 Diabetes Mellitus Before and After 3 Months of Consuming Insoluble Dietary Fiber by Mykola D Khalangot, Vitaly G Gurianov, Tamara F Zakharchenko, Yurii M Pysarenko and Victor I Kravchenko in Nutrition and Metabolic Insights
title: "Beschreibung der Unbeständigkeit der bösen Engel und Dämonen"
Creators: name: Kummer, Christian
Year: 2009

description: Im Falle von Pierre de Lancre handelt es sich um einen französischen Juristen des 16. und 17. Jahrhunderts, der durch ein Edikt des Königs Heinrich IV. in das französische Baskenland, den Labourd, beordert wird, um der dort angeblich grassierenden „Hexenseuche“ auf den Grund zu gehen. Im Zuge seiner Ermittlungen, welche im Jahre 1609 stattfinden, werden an die 80 Personen als Hexen angeklagt und zum Tode verurteilt. In seinem 1612 veröffentlichten Buch „Tableau de l’inconstance des mauvais anges et demons“ bringt er seine Erfahrungen dieser einzig großen Hexenverfolgung Frankreichs zu Papier. Die Dissertation hat zur Aufgabe, dieses Buch, welches als einer der letzten Hexentraktate bis zum Jahre 2006 noch in keine andere Sprache übertragen worden war, auf gestellte Forschungsfragen bzw. -gebiete zu untersuchen. (Untersuchung hinsichtlich der im Tableau beschriebenen Sozialgeschichte, die historische Einordnung de Lancres und seines Tableaus, die juristische Relevanz, Geschlechterforschung, politische Motive, naturwissenschaftlicher Aspekte, Entstehungsgeschichte des Tableaus). Die Aufgabe und der Sinn dieser Arbeit liegt neben der Beantwortung der Forschungsfragen (Beitrag zur wissenschaftlichen Forschung bzw. Diskussion) in dem damit verbundenen Beitrag zur Aufarbeitung eines der dunkelsten Kapitel der Geschichte der Menschheit. Mit dieser Dissertation sollten neue Perspektiven hinsichtlich der geistesgeschichtlichen Entwicklung Frankreichs und auch der sich durchsetzenden Skepsis gegenüber Hexenverfolgungen in Europa mit Fokussierung auf einzelne, noch unbehandelte Aspekte („Gender“, Sozialgeschichte, politische Motive) erarbeitet werden. Dies wurde auch mit Hilfe bzw. Vernetzung internationaler Institutionen erreicht.
description: In 17th century the King Henry IV. ordered the french lawyer Pierre de Lancre to investigate the rampant „witch disease“ in the french Basque country of Labourd. In the course of his investigations in the year 1609 eighty people were accused of witchery and sentenced to death. 1612 he published his book "Tableau de l'inconstance of mauvais anges et demons" describing his unique impressions of this largest witch persecution in France. This thesis seeks to analyze Lancres book which until 2006 was one of the few witch-treatises still untranslated. (Regarding the described social history, the historical position, legal relevance, gender studies, political motives, scientific aspects and the origin of the Tableau) The task and purpose of this work is, in addition to answering the research questions (contribution to scientific research and discussion), to help in the process of coming to terms with this darkest chapter in the history of mankind. Within this thesis new perspectives regarding the intellectual development of France and the upcoming skepticism about witchcraft persecution in Europe should be emphasized (particularly gender, social history and political motives).
Renaissance of brown adipose tissue
Creators: name: Tews, D.
name: Wabitsch, M.
Publisher: name: Universität Ulm
Year: 2011
Subjects: subject: DDC 610 / Medicine & health
subject: Adipose tissue, Brown
subject: Body temperature regulation
subject: Braunes Fettgewebe
subject: Thermoregulation

description: The recent discovery of functional brown adipose tissue in human adults raised this tissue again into the focus of current investigations concerning human energy homeostasis. Brown fat is a key thermogenic tissue and is essential for non-shivering thermogenesis in the human newborn and hibernating mammals. This review highlights the biological and molecular aspects of brown adipose tissue development and function from the embryonic state to childhood and adolescence. © In Copyright http://rightsstatements.org/vocab/InC/1.0/
Benefits of a disease management program for sickle cell disease in Germany 2011–2019 : the increased use of hydroxyurea correlates with a reduced frequency of acute chest syndrome
Creators: name: Kunz, Joachim B.
name: Schlotmann, Andreas
name: Daubenbüchel, Andrea
name: Lobitz, Stephan
name: Jarisch, Andrea
name: Grosse, Regine
name: Cario, Holger
name: Oevermann, Lena
name: Hakimeh, Dani
name: Tagliaferri, Laura
name: Kulozik, Andreas E.
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Health insurance data
subject: DDC 610 / Medicine & health
subject: Sickle cell disease
subject: Anemia, Sickle cell
subject: Epidemiology
subject: Hydroxyurea
subject: Sichelzellenanämie
subject: Epidemiologie
subject: Hydroxyharnstoff

description: Sickle Cell Disease (SCD) is the most common monogenic disorder globally but qualifies as a rare disease in Germany. In 2012, the German Society for Paediatric Oncology and Haematology (GPOH) mandated a consortium of five university hospitals to develop a disease management program for patients with SCD. Besides other activities, this consortium issued treatment guidelines for SCD that strongly favour the use of hydroxyurea and propagated these guidelines in physician and patient education events. In order to quantify the effect of these recommendations, we made use of claims data that were collected by the research institute (WIdO) of the major German insurance company, the Allgemeine Ortskrankenkasse (AOK), and of publicly accessible data collected by the Federal Statistical Office (Statistisches Bundesamt, Destatis). While the number of patients with SCD in Germany increased from approximately 2200 in 2011 to approximately 3200 in 2019, important components of the recently issued treatment guidelines have been largely implemented. Specifically, the use of hydroxyurea has more than doubled, resulting in a proportion of approximately 44% of all patients with SCD being treated with hydroxyurea in 2019. In strong negative correlation with the use of hydroxyurea, the frequency of acute chest syndromes decreased. Similarly, the proportion of patients who required analgesics and hospitals admissions declined. In sum, these data demonstrate an association between the dissemination of treatment guidelines and changes in clinical practice. The close temporal relationship between the increased use of hydroxyurea and the reduction in the incidence of acute chest syndrome in a representative population-based analysis implies that these changes in clinical practice contributed to an improvement in key measures of disease activity.
Liquid biopsy in metastasized breast cancer as basis for treatment decisions
Creators: name: Krawczyk, Natalia
name: Fehm, Tanja
name: Banys, Malgorzata Joanna
name: Janni, Wolfgang
name: Schramm, Amelie
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: Circulating tumor cells
subject: Circulating tumor DNA
subject: Metastatic breast cancer
subject: DDC 610 / Medicine & health
subject: Breast neoplasms
subject: Liquid biopsy
subject: Neoplasm metastasis
subject: Neoplastic cells, Circulating
subject: Brustkrebs
subject: Metastase
subject: Biopsie

description: According to current guidelines, the additional biopsy of breast cancer metastases to analyze the receptor status for phenotype assessment is recommended. However, due to clinical difficulties in performing biopsies of metastatic lesions, the phenotype of the primary tumor most often determines the treatment decisions in metastatic breast cancer. Liquid biopsy allows the analysis of several circulating biomarkers like circulating tumor cells (CTCs) or circulating tumor DNA (ctDNA) in peripheral blood samples of cancer patients. Thus, it is an elegant and easily practicable technique that delivers information on the current disease status. Determination of the CTC phenotype regarding the hormone receptor and human epidermal growth factor receptor 2 (HER2) status might replace additional tissue biopsy for planning further therapy strategies. Liquid biopsy is a crucial step towards a more individualized cancer therapy. In contrast to the conventional concept of tissue biopsy, it offers an easy, less invasive acquisition of biomaterial. In addition, it allows multiple repetitions and real-time monitoring of metastasized disease in the clinical routine. However, the clinical utility of liquid biopsy still needs to be evaluated. © In Copyright http://rightsstatements.org/vocab/InC/1.0/
Additional file 1 of Cost of chiropractic versus medical management of adults with spine-related musculoskeletal pain: a systematic review
Creators: name: Farabaugh, Ronald
name: Hawk, Cheryl
name: Taylor, Dave
name: Daniels, Clinton
name: Noll, Claire
name: Schneider, Mike
name: McGowan, John
name: Whalen, Wayne
name: Wilcox, Ron
name: Sarnat, Richard
name: Suiter, Leonard
name: Whedon, James
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1: Search Strategy
sj-docx-5-dps-10.1177_10442073221128917 – Supplemental material for Perceptions of Federal Workplace Attributes: Interactions Among Disability, Sex, and Military Experience
Creators: name: von Schrader, Sarah
name: Shaw, Leslie
name: Colella, Adrienne
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: Education
subject: 160512 Social Policy
subject: FOS: Political science
subject: 130312 Special Education and Disability
subject: FOS: Educational sciences

description: Supplemental material, sj-docx-5-dps-10.1177_10442073221128917 for Perceptions of Federal Workplace Attributes: Interactions Among Disability, Sex, and Military Experience by Sarah von Schrader, Leslie Shaw and Adrienne Colella in Journal of Disability Policy Studies
Antenna design for noncoherent massive MIMO systems
Creators: name: Bucher, Stephan
name: Ragab, Ahmed N.
name: Yammine, George
name: Fischer, Robert
name: Waldschmidt, Christian
Publisher: name: Universität Ulm
Year: 2018
Subjects: subject: Base stations
subject: MIMO communication
subject: Channel models
subject: DDC 620 / Engineering & allied operations
subject: MIMO systems
subject: Antenna radiation patterns
subject: Impedance (Electricity)
subject: Antennas, Dipole
subject: Basisstation
subject: MIMO
subject: Strahlungscharakteristik
subject: Kanaltheorie
subject: Widerstand
subject: Dipol

description: Massive MIMO is one of the key technologies that enables an increase in capacity in multi-user MIMO systems. However, these systems suffer from high channel estimation complexity and its degradation due to pilot contamination. An attractive way to overcome the key problems of massive MIMO is to resort to noncoherent detection since no actual channel knowledge is needed at the receiver. In this paper, an appropriate antenna design at the base station is proposed when applying noncoherent detection methods. Thereby, the influence of the main antenna characteristics, namely the radiation pattern, gain, and mutual coupling on the symbol error rate performance is assessed for realistic antennas. The evaluation is based on the COST 2100 channel model, properly adapted to the massive MIMO setting. It is shown that proper antenna design can enhance the symbol error rate performance in the noncoherent case in contrast to coherent detection. More specifically, the base station should be equipped with high gain and highly directional antennas. In addition, mutual coupling between adjacent antenna elements at base station may enhance the system performance when present.
Additional file 2 of Cost of chiropractic versus medical management of adults with spine-related musculoskeletal pain: a systematic review
Creators: name: Farabaugh, Ronald
name: Hawk, Cheryl
name: Taylor, Dave
name: Daniels, Clinton
name: Noll, Claire
name: Schneider, Mike
name: McGowan, John
name: Whalen, Wayne
name: Wilcox, Ron
name: Sarnat, Richard
name: Suiter, Leonard
name: Whedon, James
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 2: Articles excluded after full-text screening
title: Hallstattzeitliche Herrenhöfe und latènezeitliche Viereckschanzen in Deutschland
Creators: name: Horacek, Nina
Year: 2009

description: Hallstattzeitliche Herrenhöfe und latènezeitliche Viereckschanzen stellen zwei eisenzeitliche Siedlungsgattungen dar, die in der Forschung immer wieder kontrovers diskutiert und interpretiert werden. Ihre Deutung geht von umzäunten Gehöften, zentralen Handels- und Produktionsorten, über Dienstleistungsbetriebe bis zu Kultstätten. Die Fragestellungen die sich zu diesem Thema auftun sind vielfältig. Welche Funktion(en) hatten hallstattzeitliche Herrenhöfe und latènezeitliche Viereckschanzen, hatten sie die gleiche(n) Funktion(en) und waren Viereckschanzen – trotz der 300 Jahre zeitlicher Differenz - funktionelle Nachfolger von Herrenhöfen? Diese Punkte werden anhand der archäologisch fassbaren Strukturen in ergrabenen und publizierten Anlagen herausgearbeitet und verglichen. Das sind vor allem die Verbreitung und topographischer Lage, die Gestaltung der Einfriedung, die Innenbebauung, das Umfeld mit Siedlungen und Gräbern, sowie die Funde innerhalb der Anlagen. Und auch die sozialen und gesellschaftlichen Veränderungen, die zum Bau dieser Siedlungsarten geführt haben könnten, werden in einem Kapitel herausgearbeitet. Da die Art der Einfriedung in den meisten Anlagen keinen fortifikatorischen Sinn macht, werden soziale Gründe wie ein Abgrenzungs- oder Repräsentationsbedürfnis für die Anlage dieser Grabenwerke angenommen. Es bleibt noch viel Forschungsarbeit zu den Anlagen zu betreiben, um die Funktion/en endgültig zu klären. Nach derzeitigem Forschungsstand erscheinen die hallstattzeitlichen Herrenhöfe und die latènezeitlichen Viereckschanzen als typische Siedlungsformen der jeweiligen Zeitstufe, die, eingebunden in die damalige Wirtschaftslandschaft, als Zentralorte profaner und vielleicht auch sakraler Funktion dienten.