cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Untersuchungen zur enzymatischen Produktion von Ethylenoxid, Phenol und Naphthol mit der löslichen Methanmonooxygenase
Creators: name: Groen, Jann Simon
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 610

description: Die lösliche Methan-Monooxygenase (sMMO) hydroxyliert neben dem physiologischen Substrat Methan eine Vielzahl von Kohlenwasserstoffen und besitzt deshalb ein großes Potenzial für biotechnologische Anwendungen. Die komplexe Struktur, eine geringe Prozessstabilität und niedrige Produktausbeuten verhindern bislang den Einsatz in biotechnologischen Bereichen. In der vorliegenden Arbeit wird das Potenzial der sMMO aus M. trichosporium OB3b demonstriert, indem Produktions- und Reinigungsstrategien der Proteinkomponenten optimiert und verschiedene Strategien zur Steigerung der Produktausbeute verfolgt wurden. Reaktionssysteme zur enzymatischen Hydroxylierung von Ethylen, Benzol und Naphthalin wurden substratspezifisch optimiert, sodass Produktausbeuten von 98 % erreicht werden konnten. Final wurde die sMMO-Enzymkaskade zur Hydroxylierung von Ethylen in einem 700-mL-Membranreaktor und zur Hydroxylierung aromatischer Substratgemische in einem 350-mL-Rührkesselreaktor eingesetzt.
description: Soluble methane monooxygenase (sMMO) hydroxylates not only the physiological substrate methane but also a variety of organic substrates and therefore offers great potential for biotechnological applications. The complex structure, low process stability and consequently low product yields have so far prevented its use in biotechnology. Here, the potential of sMMO from M. trichosporium OB3b is demonstrated by optimizing the production and purification strategies of the protein components and implementing different strategies to increase the product yield. Reaction systems for enzymatic hydroxylation of ethylene, benzene, and naphthalene were optimized for each substrate individually resulting in product yields of up to 98 %. Finally, the sMMO enzyme cascade was used for the hydroxylation of ethylene in a 700-mL membrane reactor and for the hydroxylation of aromatic substrate mixtures in a 350-mL stirred tank reactor.
Recurrence and pressure for group extensions
Creators: name: Jaerisch, Johannes
Publisher: name: arXiv
Year: 2012
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 37D35, 37A50, 37C85 (Primary) 43A07, 30F40 (Secondary)

description: We investigate the thermodynamic formalism for recurrent potentials on group extensions of countable Markov shifts. Our main result characterises recurrent potentials depending only on the base space, in terms of the existence of a conservative product measure and a homomorphism from the group into the multiplicative group of real numbers. We deduce that, for a recurrent potential depending only on the base space, the group is necessarily amenable. Moreover, we give equivalent conditions for the base pressure and the skew product pressure to coincide. Finally, we apply our results to analyse the Poincaré series of Kleinian groups and the cogrowth of group presentations.
A unified approach to high efficiency microwave power amplifier design
Creators: name: Colantonio, P.
name: Giannini, Franco
name: Leuzzi, Giorgio
name: Limiti, Ernesto
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 1999
Subjects: ING-INF/01 Elettronica

description: A systematic approach to the design of high efficiency microwave power amplifiers is presented. The technique makes use of second and third harmonic terminating idlers to achieve major improvements in output power, gain and power added efficiency. The approach proposed in this contribution is validated by means of a sample design and realisation, illustrating both the effectiveness and the feasibility of the method, as compared to more conventional harmonic tuning strategies.
A compact broadband high efficient X-Band 9-Watt PHEMT MMIC high-power amplifier for phased array radar applications
Creators: name: De Hek, A.P.
name: Hunneman, P.A.H.
name: Demmler, M.
name: Hülsmann, A.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 1999
Subjects: ING-INF/01 Elettronica

description: In this paper the development and measure­ment results of a compact broadband 9-Watt high-efficient X-band high-power amplifier are discussed. The described amplifier has the following state-of-the-art performance: an average output power of 9 Watt, a gain of 20 dB and an average Power Added Effi­ciency of 35% over a relative bandwidth of 40% at X-band. The amplifier is realised in a pseudomorphic HEMT GaAs MMIC technology developed by the Fraunhofer Institute for Applied Solid State Physics (FhG-IAF) in the scope of the WEAG/TA1/CTP8.1 program.
Analyse von Änderungen der Genexpression mikrovaskulärer Endothelzellen im pro-inflammatorischen Milieu : Gegenüberstellung von relativer und absoluter Quantifizierung
Creators: name: Kuhlmann, Kevin
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: 610

description: In der Studie wurden zwei PCR-Methoden verwendet und verglichen: Die qPCR und die ddPCR. Der Vergleich der qPCR und der ddPCR basierte auf einem Stimulationsansatz mikrovaskulärer Endothelzellen, bei dem die Wirkung eines proinflammatorischen Milieus auf die Expression vasoaktiver Rezeptoren und weitere Zielgene untersucht wurde. Bei den meisten Genen war die Richtung der Wirkung konsistent. Beim Effektausmaß zeigten sich Abweichungen zwischen den Ergebnissen der Quantifizierungsmethoden, wenn die Messwerte an den äußeren Bereichen der dynamischen Reichweite der Testverfahren lagen. Um valide Ergebnisse zu erhalten, werden Verdünnungsreihen empfohlen. Bei der ddPCR sollte die Anzahl der Kopien pro μl auf den niedrigen dreistelligen Bereich eingestellt werden. Im Hinblick auf die qPCR ist es essentiell, dass die Zuverlässigkeit der verwendeten Referenzgene gewährleistet ist. Im Hinblick auf wirtschaftliche und zeitliche Faktoren sollten strenge Indikationen für diese Methodik gestellt werden.
description: In the study, two PCR methods were used their results were compared: qPCR and ddPCR. The comparison of the qPCR and the ddPCR was based on a stimulation approach of microvascular endothelial cells in which the effect of a pro-inflammatory milieu on the expression of vasoactive receptors and different pro-inflammatory targets was investigated. There was consistency in directions of effects for the majority of genes tested. It was striking that deviations in the dimension of the effects were more pronounced if the measured values were on the extreme edges of the dynamic range of the test procedures. To obtain valid results, dilution series are recommended, which should be carried out initially. In case of ddPCR the number of copies per μl should be adjusted to the low three-digit range. With regard to qPCR it is essential that the stability of the reference genes used is guaranteed. Here, ddPCR offers the advantage that housekeeping genes are not required. Strict indications for this methodology should also be made with regard to economic and timing factors.
Power amplifier second harmonic manipulation: mmWave application and test results
Creators: name: Betti-Berutto, A.
name: Satoh, T.
name: Khandavalli, Chandra
name: Giannini, Franco
name: Limiti, Ernesto
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 1999
Subjects: ING-INF/01 Elettronica

description: The effectiveness of second harmonic manipulation for power performance improvement at millimeter-wave frequencies is experimentally demonstrated. The new power amplifier stage clearly demonstrates superior performance with respect to a standard tuned load approach, both in terms of output power and power-added efficiency. Moreover, the IM3 test showed no significant differences in the two cases.
"You are real citizens and you have the right to love" : exploring political frames in same-sex marriage debates in Canada
Creators: name: Broderick, Julie
Publisher: name: University of British Columbia
Year: 2014

description: In 1984, Gayle Rubin introduced her influential concept of the ‘charmed circle.’ Rubin noted a dividing line between ‘good’ and ‘bad’ sexuality, and argued that those who enact ‘good’ sex are often rewarded in society, while others occupy the outer limits of acceptability. Namely, Rubin notes that within the ‘charmed circle’ are heterosexual, monogamous, procreative couples. In Rubin’s original conception, homosexuality resided on the outer limits of acceptability. However, in the current social and political context of Canada, lesbian and gay citizens have become integrated into civil society and have more freedom to live openly. This may represent emerging sexual values that complicate the sexual hierarchy. Within this political context, I ask whether, or to what extent, Rubin’s concepts of the ‘charmed circle’ and the ‘outer limits’ can be revised. I utilize frame analysis and examine data from the final debates of Bill C-38 in the House of Commons, a bill that granted same-sex couples the legal right to marry. In the debates, I discover emerging sexual values and norms that, at the level of law and state, point to an increasing valuation of coupledom, regardless of sexual orientation. In light of these emerging values and norms, I re-conceptualize Rubin’s concept of the ‘charmed circle,’ accounting for the ways that coupledom is framed as not only a private good, but as a moral good for Canada.
The kinetic fragility of liquids as manifestation of the elastic softening
Creators: name: Puosi, F.
name: Leporini, D.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We show that the fragility $m$, the steepness of the viscosity and relaxation time close to the vitrification, increases with the degree of elastic softening, i.e. the decrease of the elastic modulus with increasing temperature, in universal way. This provides a novel connection between the thermodynamics, via the modulus, and the kinetics. The finding is evidenced by numerical simulations and comparison with the experimental data of glassformers with widely different fragilities ($33 \le m \le 115$), leading to a fragility-independent elastic master curve extending over eighteen decades in viscosity and relaxation time. The master curve is accounted for by a cavity model pointing out the roles of both the available free volume and the cage softness. A major implication of our findings is that ultraslow relaxations, hardly characterised experimentally, become predictable by linear elasticity. As an example, the viscosity of supercooled silica is derived over about fifteen decades with no adjustable parameters.
description: 7 pages, 6 figures; Added new results, improved the theoretical section
Development of temperature dependent load-pull analysis techniques
Creators: name: Gebara, Edward
name: Heo, Deukhyoun
name: Laskar, Joy
name: Harris, Mike
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 1999
Subjects: ING-INF/01 Elettronica

description: Cryogenic      on-wafer      load-pull measurements are performed on GaAs MESFET (Lg=0.6um, W=300um and Lg=1.0nm, W=300um) power devices at 300K, 200K and 15K to demonstrate their performance improvement in output power and power-added efficiency when operated at reduced lattice temperatures. The power measurements were achieved at optimal bias condition to take into account the positive Temperature Coefficient (TC) that the On Breakdown Voltage exhibits. Additionally, an empirical temperature-dependent large-signal model valid to 18GHz is developed using experimental S-parameters and DC measurements to correlate actual load-pull measurements from 300K to 15K and to understand the performance improvements in output power and power-added efficiency. The model is also used to correlate the effect of the TC of Breakdown Voltage to power measurements.
MOESM6 of Integrative visual omics of the white-rot fungus Polyporus brumalis exposes the biotechnological potential of its oxidative enzymes for delignifying raw plant biomass
Creators: name: Miyauchi, Shingo
name: Rancon, Anaïs
name: Drula, Elodie
name: Hage, Hayat
name: Chaduli, Delphine
name: Favel, Anne
name: Grisel, Sacha
name: Henrissat, Bernard
name: Herpoël-Gimbert, Isabelle
name: Ruiz-Dueñas, Francisco
name: Chevret, Didier
name: Hainaut, Matthieu
name: Lin, Junyan
name: Wang, Mei
name: Pangilinan, Jasmyn
name: Lipzen, Anna
name: Lesage-Meessen, Laurence
name: Navarro, David
name: Riley, Robert
name: Grigoriev, Igor
name: Zhou, Simeng
name: Raouche, Sana
name: Rosso, Marie-Noëlle
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Computational Biology

description: Additional file 6: Table S3. CAZyme coding genes present in nodes with mean log2 read counts < 12 in control liquid cultures and mean log2 read counts > 12 at Day 4 in SSF.
Osservatorio del mercato del lavoro della provincia di Bologna: Rapporto primo semestre 2007
Creators: name: Tassinari, Giorgio
name: Camillo, Furio
name: Freo, Marzia
name: Guizzardi, Andrea
name: Liberati, Caterina
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2007
Subjects: SECS-S/03 Statistica economica

description: The Report presents the main facts about labour market in the Bologna County during the first half of 2007. As it is presented five months after the release of the 2006 the analysis about the economic and socio-demographic structure of the County are not presented. The labour market of the County seems to go fairly well. At the regional (Emilia-Romagna) level, in front of a business cycle moderately good, the number of employees is still growing (+1% in a year),  but some signals of discouragement among women labour force begins to be present (female labour force decreases of 0,6% in a year. The new fact in the Report is the it gives a complete track of every  labour contract  started during the fist six months of 2007, comphrensive of the non standard labour contracts.
Under this point of view we find a critical situation linked to the diffusion of the fixed term contracts, that are the 62% of all the contracts started. If we look at workers age we find that for every age class this percentage still is above the 55%. So we can say that workplace instability embraces every worker that is seeking a job, and that it is not limited to young people, but yet is pervasive and embraces workes of every ages. Further, using survival analysis we were able to measure the durations of jobs according the type of contract (using data from 2004 to 2004). The expect duration of a job is 180 days, but if we rescrtict to fixed term contracts the duration falls to 70 days. Moreover, the probability of staying in the condition of fixed term worker, after 3 years, is still 90%.
A Solution to the Flavor Problem of Warped Extra-Dimension Models
Creators: name: Bauer, Martin
name: Malm, Raoul
name: Neubert, Matthias
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: A minimal solution to the flavor problem of warped extra-dimension models, i.e. the excessive mixed-chirality contribution to CP violation in K-Kbar mixing arising from Kaluza-Klein (KK) gluon exchange, is proposed. Extending the strong-interaction gauge group in the bulk by an additional SU(3), and breaking this symmetry to QCD via boundary conditions, the constraints arising from the epsilon_K parameter are significantly relaxed. As a result, KK scales M_KK ~ 2 TeV are consistent with all flavor observables without significant fine-tuning. The model predicts the existence of an extended Higgs sector featuring massive color-octet scalars and a tower of KK pseudo-axial gluon resonances, whose existence is not in conflict with recent LHC dijet bounds.
description: Added discussion of the extended scalar sector and its impact on the choice of boundary conditions. Corrected the Wilson coeffcients in (12) by a symmetry factor of 1/2 and updated the plots in Figure 2 with improved fitting functions. Main conclusions unchanged
Osservatorio del mercato del lavoro della provincia di Bologna: Rapporto 2006
Creators: name: Tassinari, Giorgio
name: Camillo, Furio
name: Freo, Marzia
name: Guizzardi, Andrea
name: Liberati, Caterina
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2007
Subjects: SECS-S/03 Statistica economica

description: The Report presents the main informations about labour market in the county of Bologna during 2006. The Bologna labour market goes fairly well: in front of a positive business cycle employment is still growing and Bologna county has met many of the Lisbon targets. Nevertheless, in a comparison with European regions some weaknesses are shown, mainly for what concerns human capital formation and flexibility of firms’ organization. Moreover, the quality of employment is worsening, as a growing percentage of new jobs are on of a fixed term kind.
Messung der physikalischen Eigenschaften von Implantatmagneten und deren Einfluss auf die Kopfhaut und das Trageverhalten von Patienten
Creators: name: Hönig, Elisabeth Katharina
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: 610

description: Audioprozessormagneten, welche in teilimplantierbaren Hörsystemen verwendet werden, variieren in ihrer Magnetanziehungskraft aufgrund verschiedener verfügbarer Magnetstärken und unterschiedlicher Hautlappendicken unter dem Audioprozessormagneten. Eine optimale Magnetanziehungskraft kann für jeden Patienten als Kompromiss zwischen dem bestmöglichem Halt und der Hautschonung bestimmt werden. Die Vorhersage dieser Kraft kann auf der Grundlage einer Laborfunktion (Magnetanziehungskraft-Entfernungs-Funktion) erfolgen. Eine zu kleine Magnetanziehungskraft führt zu einem häufigeren Lösen des Prozessors oder der extern sitzenden Spule von der Kopfhaut, eine zu groß gewählte verursacht Schmerzen und Hautirritationen. Es wurden im Rahmen der klinischen Studie die In-Situ-Magnetanziehungskräfte bei 96 Patienten mit teilimplantierbaren Hörsystemen und der Hautstatus objektiv und mithilfe eines Fragebogens erfasst. Die optimale Magnetanziehungskraft befindet sich in einem Bereich von 0,23-0,4 N.
description: Audio processor magnets, which are used in semi-implantable hearing aids, do vary as to magnetic retention force because of several magnetic forces that are available and different thickness of skin flap. In this context it’s necessary to make a compromise between the best possible grip and skin protection, to get the optimal magnetic retention force. To predict the perfect magnetic retention force, the “force distance function” (laboratory function) is used. A magnetic retention force, which is too low can cause the remove of the processor or the coil on the scalp. Furthermore, a magnetic retention force which is too high can cause skin irritations and pain. As part of the clinical trial the In-Situ-magnetic-retention-force of 96 patients, which had worn semi-implantable hearing aids, were recorded. Additionally, the skin status was recorded by means of questionnaire. The optimal magnetic retention force can be found between 0,23-0,4 N.
Dai registri amministrativi ai sistemi informativi integrati per cooperative sociali ed aziende di terzo settore - Note da un progetto
Creators: name: Travaglini, Claudio
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2007
Subjects: SECS-P/07 Economia aziendale

description: La situazione attuale dei registri e degli albi della cooperazione sociale e dei complessivi registri ed albi delle organizzazioni di terzo settore nel nostro territorio potrebbe essere sinteticamente descritta come “molti registri, poche informazioni e pochi controlli” in quanto caratterizzata dalla presenza di adempimenti amministrativi e raccolta di dati in gran parte asistematici ed a cui spesso non corrisponde la costruzione di un quadro informativo né la conduzione di una incisiva attività di controllo su questi enti.
La macro fase 4 “Directory delle cooperative sociali” del progetto Spring-Out condotta dal Polo Scientifico-Didattico di Rimini  dell’università di Bologna si caratterizza come un progetto per trasformare l’adempimento amministrativo dell’iscrizione delle cooperative sociali ai registri provinciali previsti dalla normativa nella definizione di un sistema informativo della cooperazione sociale.
A partire da questa constatazione si propone la riprogettazione della directory delle cooperative sociali della Provincia di Rimini in forma di sistema informativo integrato basato su un modello avanzato di supporto informatico che consenta di unire alle funzioni di certificazione e notificazione tipiche dell’attuale registro, la potenzialità di osservazione sistematica dell’evoluzione dell’economia sociale sul territorio attraverso il monitoraggio dei valori economici e della partecipazione personale, con particolare riferimento al rapporto di questi soggetti con le amministrazioni pubbliche.
Structural comparison of source code between multiple programming languages
Creators: name: Biehn, Rolf
Publisher: name: University of British Columbia
Year: 2014

description: Software developers are often faced with the task of comparing two or more versions of software. Typical usages of software comparison utilities include: a code-review prior to checkin, tracking down a recently introduced regression, and searching for code-clones in the source code (for future refactoring). However, most traditional source code comparison tools typically use simple text-to-text comparison (with some simple rule-based comparisons for comments), which has the drawback of showing superfluous differences during comparison. Many projects, for a variety of business reasons, ship products and software development kits (SDKs) using multiple programing languages. It is desirable to compare amongst languages in order to detect potential errors and understand the meaningful differences between the two codebases. In some cases, fixes may be implemented in one language, but not in the other. In this paper, we create a tool called the Software Difference Analyzer Tool (SDAT), a tool capable of comparing Java and CSharp code, to address some of the unique problems associated with cross-language comparison. Automated testing demonstrated SDAT reduces the number of reported differences by up to 40%. User testing has shown a 37% increase in speed and 28% increase in accuracy.
Old ore mining places research and inventory as part of protection and use mining heritage of Lower Silesia
Creators: name: Madziarz, Maciej
name: Sztuk, Henryk
Publisher: name: Wroclaw University of Science and Technology, Faculty of Geoengineering, Mining and Geology
Year: 2012
Subjects: history, ore mining, exploration and exploitation of deposits, Sudety

description: Mining Science
Einfluss von Geschlechtsdimorphismus, Leistungsfähigkeit und Alter auf die Belastungs- und Erholungskinetik nach standardisierten, lokomotorischen Intervallbelastungen
Creators: name: Möhle, Martin
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 796

description: Hochintensives Intervalltraining, das durch wiederholende kurze bis lange Belastungen mit hoher Intensität, unterbrochen von Regenerationsphasen, charakterisiert ist, stellt eine zeiteffiziente Trainingsmethodik zur Verbesserung der Leistungsfähigkeit des Sportlers dar. Bisherige Untersuchungen zeigen, dass physiologische und anatomische Unterschiede bei Männern und Frauen zu Divergenzen in der Trainingsreaktion führen können. Weiterhin deutet der Forschungsstand darauf hin, dass Veränderungen der Skelettmuskulatur und verschiedener Funktionssysteme im Altersverlauf unterschiedliche Reaktionen auf einen Belastungsreiz auslösen können. Die Ergebnisse zeigen dabei, dass ein Geschlechtsdimorphismus in der Belastung und Erholung bei Intervallbelastungen vorliegt. Des Weiteren konnte festgestellt werden, dass eine gute Trainierbarkeit im Alter möglich ist, was wiederum die altersbedingten Veränderungen und deren Einfluss auf das Belastungs- und Erholungsverhalten konterkarieren kann.
description: High-intensity interval training, characterized by repetitive short to long bouts of high-intensity exercise separated by recovery periods, represents a time-efficient training methodology for improving athlete performance. Previous research indicates that physiological and anatomical differences in men and women may result in divergences in training response. Furthermore, the state of research suggests that changes in skeletal muscle and different functional systems over the course of age may induce different responses to an exercise stimulus. In this regard, the results show that there is a sexual dimorphism in load and recovery during interval exercise. Furthermore, it was found that good trainability is possible in old age, which in turn may counteract age-related changes and their influence on load and recovery behavior.
APOE Leu159Pro Sanger
Creators: name: Bagaria, Jaya
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 60408 Genomics
subject: Neuroscience
subject: 60410 Neurogenetics

description: This is the Sanger sequencing file of APOE Leu159Pro of our patient with sporadic Early Onset Alzheimer's Disease.
The determinants of marriage and cohabitation in Europe
Creators: name: Pasquini, Lucia
name: Samoggia, Alessandra
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2007
Subjects: SECS-S/04 Demografia

description: According to the theory of ideational shifts [Preston 1986], the growing spread of new forms of life as a couple may be attributed to the increase in individual autonomy in the ethical, religious and political field, i.e. to changes in the scale of subjective values. The cultural dimension influences the acceptance and experimentation of the different forms of union in a different way for the man and for the woman. The importance at the explanatory phase of taking account of ideational factors in addition to economic ones has been discussed in depth and demonstrated in the case of certain countries of central Europe by Lesthaeghe and Moors [1996]. And it is the framework of Lesthaeghe and Moors which we take as our starting point in this study, for the analysis from a gender perspective of the role played by value orientations in the choice of the various forms of life as a couple, marriage and cohabitation, in certain areas of Europe. In particular, cohabitation will be taken as representing that type of partnership which, at least theoretically, is associated with a reduction in gender differences: indeed, the absence of pre-established roles for the partners should render the relationship within the couple more egalitarian and free. Moreover, in consideration of the fact that the various European countries exhibit a distribution of types of union which is extremely differentiated [Kiernan 2000], we wish to assess whether there is any corresponding existence of similarly differentiated ideational factors; indeed, we cannot necessarily assume that the same value orientations lead to similar patterns of behaviour [Lesthaeghe 1998].
title: Взаимодействие власти и бизнеса в индустрии туризма
Creators: name: Киварина, Мария
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2021

description: Положительный опыт партнерского взаимодействия органов государственной власти и бизнеса на сегодняшний день сформировался во многих секторах экономики. В условиях перманентного экономического кризиса, пандемии, социальной и политической нестабильности только совместное объединение ресурсов властного и
предпринимательского секторов сможет стать драйвером успешного развития индустрии туризма. Целью статьи является исследование специфики взаимодействия власти и бизнеса в туристической сфере и выявление перспективных направлений их сотрудничества. В статье рассмотрены возможные сферы партнерских отношений власти и бизнеса, приведены конкретные примеры положительных эффектов для каждой из взаимодействующих сторон. Предложена система показателей для оценки эффективности развития туристической сферы на конкретной территории. Сделан вывод о том, что только баланс приведенных показателей является залогом устойчивого развития индустрии туризма.
Thermal properties of charge noise sources
Creators: name: Gustafsson, Martin V.
name: Pourkabirian, Arsalan
name: Johansson, Göran
name: Clarke, John
name: Delsing, Per
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Measurements of the temperature and bias dependence of Single Electron Transistors (SETs) in a dilution refrigerator show that charge noise increases linearly with refrigerator temperature above a voltage-dependent threshold temperature, and that its low temperature saturation is due to SET self-heating. We show further that the two-level fluctuators responsible for charge noise are in strong thermal contact with the electrons in the SET, which can be at a much higher temperature than the substrate. We suggest that the noise is caused by electrons tunneling between the SET metal and nearby potential wells.
D7.6: Dissemination Pack
Creators: name: Papadakis, Dimitrios
name: Mamais, Eleftherios
name: Nefeli Politi-Stergiou
Publisher: name: Zenodo
Year: 2016

description: This deliverable reports on the APOLLO Dissemination Pack: a collection of communication, dissemination and marketing material to promote greater awareness of the project.

The Dissemination Pack is comprised of:

	The APOLLO Brochure
	The APOLLO Leaflet
	The APOLLO Website
	The APOLLO Newsletter
	The APOLLO Fact Sheets
	The APOLLO Press Kit

The brochure and website are available in their first versions (the brochure is undergoing finalisation based on comments received from partners). The newsletter is operational and the first edition has been delivered. In agreement with the project coordinator, the fact sheets have been postponed due the current maturity level of the technical solution. The leaflet is still in production but is expected to be delivered within the next month. The full press kit will be made available upon the completion of the full set of documents, in the meanwhile, a partial press kit will be delivered to journalists.
Additional file 1: of The R2R3-MYB transcription factor PaMYB10 is involved in anthocyanin biosynthesis in apricots and determines red blushed skin
Creators: name: Xi, Wanpeng
name: Feng, Jing
name: Liu, Yu
name: Zhang, Shikui
name: Zhao, Guohua
Publisher: name: figshare
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Table S1. Color indexes of apricot fruits at different developmental stages. (PDF 251 kb)
A Novel M-Estimator for Robust PCA
Creators: name: Zhang, Teng
name: Lerman, Gilad
Publisher: name: arXiv
Year: 2011
Subjects: subject: Machine Learning (stat.ML)
subject: Optimization and Control (math.OC)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: We study the basic problem of robust subspace recovery. That is, we assume a data set that some of its points are sampled around a fixed subspace and the rest of them are spread in the whole ambient space, and we aim to recover the fixed underlying subspace. We first estimate "robust inverse sample covariance" by solving a convex minimization procedure; we then recover the subspace by the bottom eigenvectors of this matrix (their number correspond to the number of eigenvalues close to 0). We guarantee exact subspace recovery under some conditions on the underlying data. Furthermore, we propose a fast iterative algorithm, which linearly converges to the matrix minimizing the convex problem. We also quantify the effect of noise and regularization and discuss many other practical and theoretical issues for improving the subspace recovery in various settings. When replacing the sum of terms in the convex energy function (that we minimize) with the sum of squares of terms, we obtain that the new minimizer is a scaled version of the inverse sample covariance (when exists). We thus interpret our minimizer and its subspace (spanned by its bottom eigenvectors) as robust versions of the empirical inverse covariance and the PCA subspace respectively. We compare our method with many other algorithms for robust PCA on synthetic and real data sets and demonstrate state-of-the-art speed and accuracy.
Quantum ergodic restriction for Cauchy data: Interior QUE and restricted QUE
Creators: name: Christianson, Hans
name: Toth, John
name: Zelditch, Steve
Publisher: name: arXiv
Year: 2012
Subjects: subject: Analysis of PDEs (math.AP)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We prove a quantum ergodic restriction theorem for the Cauchy data of a sequence of quantum ergodic eigenfunctions on a hypersurface $H$ of a Riemannian manifold $(M, g)$. The technique of proof is to use a Rellich type identity to relate quantum ergodicity of Cauchy data on $H$ to quantum ergodicity of eigenfunctions on the global manifold $M$. This has the interesting consequence that if the eigenfunctions are quantum unique ergodic on the global manifold $M$, then the Cauchy data is automatically quantum unique ergodic on $H$ with respect to operators whose symbols vanish to order one on the glancing set of unit tangential directions to $H$.
description: 9 pages. Final version; incorporates referees' comments. To appear in MRL
Overall cost/benefit analysis for hybridGEOTABS buildings
Creators: name: Ferkl, Lukáš
name: Cigler, Jiří
Publisher: name: Zenodo
Year: 2021
Subjects: hybridGEOTABS, H2020, Cost-benefit analysis,

description: We have performed a detailed cost/benefit analysis (CBA) for the four case study buildings of our project – Haus M, Líbeznice, Infrax/Fluvius and Ter Potterie. For the CBA, we followed the EC directive number 244/2012 (1), which brings templates and methods to calculate the global financial cost in the sense of the net present value. The CBAs have been calculated according to national price levels and specific parameters (such as discount rate or primary energy conversion ratio). For all the case study buildings, the hybridGEOTABS solution with MPC was recommended – with slightly higher global financial cost, this solution ensures much lower environmental impact than the baseline variants. In addition, a variant with added photovoltaic panels was also considered, and this brought additional decrease in both global financial value and environmental impact in terms of ETS.
Role of biglycan on the immunogenicity of tumor cells
Creators: name: Subbarayan, Karthikeyan
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 610

description: Eine verminderte Biglykan (BGN)-Expression wurde in verschiedenen Tumoren gefunden und es gibt Hinweise, dass auch eine Assoziation mit Tumorigenität besteht. Um eine Verbindung zwischen dem Onkogen HER-2/neu und BGN herzustellen, wurden folgende in vitro-Modelle wie murine Fibroblasten und humane Mamma- und Melanomkarzinomzellen verwendet. Die BGN-Rekonstituierung war bei immunkompetenten Mäusen weniger tumorig, was mit einer Zunahme von Immuneffektorzellen in Tumoren und peripheren Blut einherging. Die erhöhte Immunogenität war auf hochregulierte MHC-Klasse-I und reduziertes miR-21-3p und TGF-β zurückzuführen. Die Bindung von miR-21-3p an murinem SMAD2 oder humanem TAP1 führt zu einer erhöhten NK-Zellerkennung. Diese Ergebnisse stimmten mit Datensätzen von Brustkrebspatientinnen überein. Daher berichtet diese Studie über die Rolle von BGN bei dem HER-2/neu-vermittelten immune escape und identifiziert die miR-21-TGF-β-BGN-MHC-Klasse-I-Achse als innovatives Therapiekonzept.
description: Biglycan (BGN) underexpression was found in tumors of distinct origins, and evidence suggests an association with tumorigenicity. To establish a mechanistic link between the oncogene HER-2/neu and BGN, in vitro models of HER-2/neu-overexpressing murine fibroblasts and human mammary and melanoma carcinoma lesions were used. BGN restoration was less tumorigenic in immune-competent mice, which was associated with enhanced immune cell responses and higher frequencies of immune effector cells in tumors and peripheral blood. The increased immunogenicity was due to upregulated MHC class I and reduced miR-21-3p and TGF-β. Binding of miR-21-3p with murine SMAD2 or human TAP1 was accompanied by an increased natural killer cell recognition. These results was in accordance with datasets of breast cancer patients. Thus, this study reports the role of BGN in the HER-2/neu-mediated immune escape and identified the miR-21-TGF-β-BGN-MHC class I axis as an innovative therapeutic concept.
Elga Mark-Kuriku välipäevik nr 12
Creators: name: Mark-Kurik, Elga
Publisher: name: Tallinna Tehnikaülikooli Geoloogia Instituut
Year: 1956
Subjects: Estonia
Pskov
Leningrad
Devonian
outcrop

description: Field notebook with descriptions of Devonian outcrops in Estonia, Pskov and Leningrad Oblast.
Translating Text and Context: Translation Studies and Systemic Functional Linguistics. Vol. 1 Translation Theory.
Creators: name: Manfredi, Marina
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2008
Subjects: L-LIN/12 Lingua e traduzione - Lingua inglese

description: This two-volume work has been conceived as a resource for graduate students of a course in Translation Studies, focused both on the main theoretical issues of the discipline and on the practical task of translating, in particular from English into Italian. Within a wide range of different contemporary approaches and methods, the purpose of Translating Text and Context is to offer a particular perspective on the theory and practice of translation, that of the framework of Systemic Functional Linguistics (SFL), which, we believe, can prove valuable for the study of a phenomenon that we consider “[...] a complex linguistic, socio-cultural and ideological practice” (Hatim & Munday 2004: 330). Volume 2 is expected to appear in early 2009.
Is the k-NN classifier in high dimensions affected by the curse of dimensionality?
Creators: name: Pestov, Vladimir
Publisher: name: arXiv
Year: 2011
Subjects: subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences
subject: I.2.6
subject: 62H30, 68H05

description: There is an increasing body of evidence suggesting that exact nearest neighbour search in high-dimensional spaces is affected by the curse of dimensionality at a fundamental level. Does it necessarily mean that the same is true for k nearest neighbours based learning algorithms such as the k-NN classifier? We analyse this question at a number of levels and show that the answer is different at each of them. As our first main observation, we show the consistency of a k approximate nearest neighbour classifier. However, the performance of the classifier in very high dimensions is provably unstable. As our second main observation, we point out that the existing model for statistical learning is oblivious of dimension of the domain and so every learning problem admits a universally consistent deterministic reduction to the one-dimensional case by means of a Borel isomorphism.
description: 24 pages, 6 figures, 1 table, latex2e with Elsevier macros. The Introduction is somewhat expanded, one figure added. To appear in a special issue of Computers & Mathematics with Applications
Published population pharmacokinetic models of valproic acid in adult patients: a systematic review and external validation in a Chinese sample of inpatients with bipolar disorder
Creators: name: Zang, Yan-Nan
name: Guo, Wei
name: Dong, Fang
name: Li, An-Ning
name: de Leon, Jose
name: Ruan, Can-Jun
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: This study reviewed all published valproic acid (VPA) population pharmacokinetic (PPK) models in adult patients and assessed them using external validation methods to determine predictive performance. Thirteen published PPK models (labeled with letters A to M) not restricted to children were identified in PubMed, Embase, and Web of Science databases. They were evaluated in a sample totaling 411 serum concentrations from 146 adult inpatients diagnosed with bipolar disorder in a Chinese hospital. Serum concentrations of VPA were analyzed by validated ultra-performance liquid chromatography-tandem mass spectrometry. Performance was assessed by four tests (prediction-based diagnostics, visual predictive checks, normalized prediction distribution error, and Bayesian forecasting). Models K and L, developed in large samples of Chinese and Thai patients, showed good performance in our Chinese dataset. Models H and J demonstrated good performance in 2 and 3 of the 4 tests, respectively. Another seven models exhibited intermediate performance. The models with the worst performance, F and M, could not be improved by Bayesian forecasting. In our validation study, the most important factors contributing to good performance were absence of children, Asian ethnicity, one-compartment models, and inclusion of body weight and VPA dose in previously published models.
Compact interface property for symbiotic branching
Creators: name: Etheridge, Alison M.
name: Fleischmann, Klaus
Publisher: name: Weierstrass Institute
Year: 2003
Subjects: subject: Symbiotic branching
subject: mutually catalytic branching
subject: stepping stone model
subject: Anderson model
subject: interacting superprocess
subject: stochastic equation
subject: collision localtime
subject: self-dual
subject: moment dual
subject: moment equations
subject: correlated noise
subject: colourednoise
subject: compact interface property
subject: at most linear speed of propagation
subject: 60K35
subject: 60G57
subject: 60J80

description: A process which we call symbiotic branching, is suggested covering three well-known interacting models: mutually catalytic branching, the stepping stone model, and the Anderson model. Basic tools such as self-duality, particle system moment duality, measure case moment duality, and moment equations are still available in this generalized context. As an application, we show that in the setting of the one-dimensional continuum the compact interface property holds: starting from complementary Heaviside states, the interface is finite at all times almost surely.
Predicting diffusion and feasibility of irrigation schemes: a case study in Kurdistan, Iraq
Creators: name: Zagonari, Fabio
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2011
Subjects: SECS-P/01 Economia politica

description: This paper applies ex ante econometric, cost–benefit, and financial methodologies to predict diffusion and feasibility of the irrigation project in Shahrazoor, Kurdistan, Iraq. To do so, I investigated the socio-economic, psycho-cultural, and financial factors that determine participation. The socio-economic part of the econometric analysis showed that the project was appreciated more by poorer and economically weaker farmers who rely on agriculture than those who rely on livestock activities. The psycho-cultural part of the econometric analysis emphasized that the project was appreciated more by literate farmers who adopt a maximization (rather than a status quo) approach. The cost–benefit analysis applied to the irrigation project tailored to poorer and weaker farmers determined an acceptable internal rate of return, but the financial analysis highlighted that values for water prices, a feasible internal rate of return and loan interest rates that simultaneously meet the government and farmer budgets might not exist.
Application of computer-based methods to identify and investigate ligands for proteins with high flexible binding sites
Creators: name: Luise, Chiara
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 610

description: Computergestütztes Wirkstoffdesign (CADD) wird in der pharmazeutischen Industrie und in dem akademischen Bereich ausgiebig eingesetzt und spielt heute eine zentrale Rolle in der Wirkstoffentwicklung. Die vorliegende Arbeit befasst sich mit den am häufigsten verwendeten in silico Methoden, die in der Arzneimittelentwicklung eingesetzt werden, und hebt ihre Anwendungen, Potenzial, und Beschränkungen hervor. Die Ergebnisse der vorliegenden Arbeit zeigen, wie diese Methoden in verschiedenen Projekten angewandt wurden, um unter anderem die Entdeckung und Entwicklung neuer niedermolekularen Inhibitoren zu beschleunigen, die Flexibilität von Proteinen zu untersuchen und den Bindungsmodus von sowohl niedermolekularen als auch peptidischen Liganden zu erforschen. Die hier vorgestellten Studien befassen sich mit verschiedenen Aspekten der Arzneimittelentdeckung und versuchen, spezifische Fragen und Herausforderungen zu lösen, die mit dem Projekt/Target in Zusammenhang stehen.
description: Computer-aided drug design (CADD) methodologies are extensively used in pharmaceutical industries and academia, and nowadays play a pivotal role in the drug discovery pipeline. The current work illustrates the most widely used in silico techniques in drug discovery, emphasizing their applications, potential, limitations and alternative solutions to overcome those limitations –when possible. The results show how these methodologies have been applied in diverse projects to accelerate the discovery of new small molecule inhibitors for flexible protein binding pockets. Specifically, the studies presented herein cover different drug discovery aspects and try to address specific questions and challenges that are project/target related.
Predicting HPGR performance and understanding rock particle behavior through DEM modelling
Creators: name: Kumar, Amit
Publisher: name: University of British Columbia
Year: 2014

description: High pressure grinding rolls (HPGR) are becoming an increasingly popular energy efficient solution for comminution of hard rock ores. A significant barrier to the increased adaptation of HPGRs is the current requirement for large amounts of sample for pilot testing. The primary objective of the research was to develop a DEM based computer model for an HPGR to analyze the particle behavior in the unit and to predict its sizing information. EDEM, a DEM based software, was used to model the pilot scale HPGR unit and single particle compression test was used to evaluate the particle breakage and then used as an input parameter for the simulations. The results obtained from the simulation were then validated with the results from the pilot scale tests. Results obtained from the simulation suggested that a DEM-based model can be used to identify the pressure/force distribution profile for an HPGR roll surface that can then be used to design the appropriate piston geometry to match the HPGR pressure profile. Also, the developed HPGR model was used to estimate the critical sizing information for certain samples and machine operating conditions. The model generated similar trends as the pilot scale test with a lower magnitude of m-dot and specific energy consumption primarily due to the absence of a packed particle bed. The HPGR model, combined with powerful computers and larger sample masses for simulation, can be used as a procedure to size and select an industrial HPGR unit and to analyze the equipment behavior under various operating conditions and feed characteristics.