cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Anti-tumor activity of splice-switching oligonucleotides
Creators: name: Kole, Ryszard
name: Yang, Angela
name: Bauman, John A.
name: Li, Shyh Dar
name: Huang, Leaf
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Alternative splicing has emerged as an important target for molecular therapies. Splice-switching oligonucleotides (SSOs) modulate alternative splicing by hybridizing to pre-mRNA sequences involved in splicing and blocking access to the transcript by splicing factors. Recently, the efficacy of SSOs has been established in various animal disease models; however, the application of SSOs against cancer targets has been hindered by poor in vivo delivery of antisense therapeutics to tumor cells. The apoptotic regulator Bcl-x is alternatively spliced to express anti-apoptotic Bcl-xL and pro-apoptotic Bcl-xS. Bcl-xL is upregulated in many cancers and is associated with chemoresistance, distinguishing it as an important target for cancer therapy. We previously showed that redirection of Bcl-x pre-mRNA splicing from Bcl-xL to -xS induced apoptosis in breast and prostate cancer cells. In this study, the effect of SSO-induced Bcl-x splice-switching on metastatic melanoma was assessed in cell culture and B16F10 tumor xenografts. SSOs were delivered in vivo using lipid nanoparticles. Administration of nanoparticle with Bcl-x SSO resulted in modification of Bcl-x pre-mRNA splicing in lung metastases and reduced tumor load, while nanoparticle alone or formulated with a control SSO had no effect. Our findings demonstrate in vivo anti-tumor activity of SSOs that modulate Bcl-x pre-mRNA splicing.
Additional file 4 of Determining the benefits and drawbacks of parents using personal connections and social networks for recruitment in research projects: a qualitative study
Creators: name: Kim, Laesa
name: Costello, Carrie
name: Golding, Michael A.
name: Janse van Rensburg, Chloé
name: Protudjer, Jennifer L. P.
name: Wittmeier, Kristy
Publisher: name: figshare
Year: 2023
Subjects: subject: Sociology
subject: FOS: Sociology

description: Additional file 4. Tip sheets for researchers and parent partners.
Intersecting $P$-free families
Creators: name: Gerbner, Dániel
name: Methuku, Abhishek
name: Tompkins, Casey
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: We study the problem of determining the size of the largest intersecting $P$-free family for a given partially ordered set (poset) $P$. In particular, we find the exact size of the largest intersecting $B$-free family where $B$ is the butterfly poset and classify the cases of equality. The proof uses a new generalization of the partition method of Griggs, Li and Lu. We also prove generalizations of two well-known inequalities of Bollobás and Greene, Katona and Kleitman in this case. Furthermore, we obtain a general bound on the size of the largest intersecting $P$-free family, which is sharp for an infinite class of posets originally considered by Burcsi and Nagy, when $n$ is odd. Finally, we give a new proof of the bound on the maximum size of an intersecting $k$-Sperner family and determine the cases of equality.
description: Improved the writing following the suggestions of referees. Published version available via http://www.sciencedirect.com/science/article/pii/S009731651730047X
Fitting surface-independent phase shift differences
Creators: name: Winther, Mark Lykke
name: Rørsted, Jakob Lysgaard
name: Roxburgh, Ian
name: Verma, Kuldeep
name: Cunha, Margarida S.
name: Stokholm, Amalie
Publisher: name: Zenodo
Year: 2024

description: With the great inference power asteroseismology brings to model fitting of stars, one of the greatest challenges is the asteroseismic surface effect. While it has previously been circumvented using combinations of individual frequencies, most often the frequency separation ratios, they are derived using several approximations, which decreases the precision of the inferred parameters. Here, we present the epsilon differences method, which relies on how specific combinations of individual frequencies cancel out the contribution from the surface, derived using less approximations than frequency separation ratios, and show how it performs in comparison to the established methods.
Assessing serotonin receptor mRNA editing frequency by a novel ultra high-throughput sequencing method
Creators: name: Farrell, Martilias S.
name: Kroeze, Wesley K.
name: Jensen, Niels H.
name: Roth, Bryan L.
name: Wang, Zefeng
name: Mieczkowski, Piotr
name: Abbas, Atheir I.
name: Urban, Daniel J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: RNA editing is a post-transcriptional modification of pre-mRNA that results in increased diversity in transcriptomes and proteomes. It occurs in a wide variety of eukaryotic organisms and in some viruses. One of the most common forms of pre-mRNA editing is A-to-I editing, in which adenosine is deaminated to inosine, which is read as guanosine during translation. This phenomenon has been observed in numerous transcripts, including the mammalian 5-HT2C receptor, which can be edited at five distinct sites. Methods used to date to quantify 5-HT2C receptor editing are labor-intensive, expensive and provide limited information regarding the relative abundance of 5-HT2C receptor editing variants. Here, we present a novel, ultra high-throughput method to quantify 5-HT2C receptor editing, compare it to a more conventional method, and use it to assess the effect of a range of genetic and pharmacologic manipulations on 5-HT2C editing. We conclude that this new method is powerful and economical, and we provide evidence that alterations in 5-HT2C editing appear to be a result of regional changes in brain activity, rather than a mechanism to normalize 5-HT2C signaling.
The elevated Curie temperature and half-metallicity in the ferromagnetic semiconductor La$_{x}$Eu$_{1-x}$O
Creators: name: Monteiro, Pedro M. S.
name: Baker, Peter J.
name: Hine, Nicholas D. M.
name: Steinke, Nina-J.
name: Ionescu, Adrian
name: Cooper, Joshaniel F. K.
name: Barnes, Crispin H. W.
name: Kinane, Christian J.
name: Salman, Zaher
name: Wildes, Andrew R.
name: Prokscha, Thomas
name: Langridge, Sean
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Here we study the effect of La doping in EuO thin films using SQUID magnetometry, muon spin rotation ($μ$SR), polarized neutron reflectivity (PNR), and density functional theory (DFT). The $μ$SR data shows that the La$_{0.15}$Eu$_{0.85}$O is homogeneously magnetically ordered up to its elevated $T_{\rm C}$. It is concluded that bound magnetic polaron behavior does not explain the increase in $T_{\rm C}$ and an RKKY-like interaction is consistent with the $μ$SR data. The estimation of the magnetic moment by DFT simulations concurs with the results obtained by PNR, showing a reduction of the magnetic moment per La$_{x}$Eu$_{1-x}$O for increasing lanthanum doping. This reduction of the magnetic moment is explained by the reduction of the number of Eu-4$f$ electrons present in all the magnetic interactions in EuO films. Finally, we show that an upwards shift of the Fermi energy with La or Gd doping gives rise to half-metallicity for doping levels as high as 3.2 %.
description: 7 pages, 11 figures
Male size of nest owners and sneakers in 17°C and 21°C mesocosms from Within-generation and transgenerational plasticity of mate choice in oceanic stickleback under climate change.
Creators: name: Fuxjäger, Lukas
name: Wanzenböck, Sylvia
name: Ringler, Eva
name: K. Mathias Wegner
name: Ahnelt, Harald
name: Shama, Lisa N. S.
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology

description: Bar chart showing male size of nest owners and sneakers in the two mesocosm temperatures, and table showing GLMM results for effects of male status, male temperature and mesocosm temperature on male size.
BRG1 co-localizes with DNA replication factors and is required for efficient replication fork progression
Creators: name: Bultman, Scott J.
name: Groh, Beezly S.
name: Kaufman, David G.
name: Weissman, Bernard E.
name: Rosson, Gary B.
name: Cohen, Stephanie M.
name: Chastain II, Paul D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: For DNA replication to occur, chromatin must be remodeled. Yet, we know very little about which proteins alter nucleosome occupancy at origins and replication forks and for what aspects of replication they are required. Here, we demonstrate that the BRG1 catalytic subunit of mammalian SWI/SNF-related complexes co-localizes with origin recognition complexes, GINS complexes, and proliferating cell nuclear antigen at sites of DNA replication on extended chromatin fibers. The specific pattern of BRG1 occupancy suggests it does not participate in origin selection but is involved in the firing of origins and the process of replication elongation. This latter function is confirmed by the fact that Brg1 mutant mouse embryos and RNAi knockdown cells exhibit a 50% reduction in replication fork progression rates, which is associated with decreased cell proliferation. This novel function of BRG1 is consistent with its requirement during embryogenesis and its role as a tumor suppressor to maintain genome stability and prevent cancer.
A topological characterisation of endomorphism monoids of countable structures
Creators: name: Bodirsky, Manuel
name: Schneider, Friedrich Martin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Logic (math.LO)
subject: FOS: Mathematics

description: A topological monoid is isomorphic to an endomorphism monoid of a countable structure if and only if it is separable and has a compatible complete ultrametric such that composition from the left is non-expansive. We also give a topological characterisation of those topological monoids that are isomorphic to endomorphism monoids of countable omega-categorical structures. Finally we present analogous characterisations for polymorphism clones of countable structures and for polymorphism clones of countable omega-categorical structures.
description: 16 pages; minor corrections have been made in version 2
title: Improvement in wheat doubled haploidy
Creators: name: Ferrie, A.
name: Brost, J.
name: Caswell, K.
name: Enns, J.
name: Nelson, K.
name: Polvi, S.
name: Roewer, I.
name: Trowell, B.
name: Huang, H. M.
name: Eudes, F.
name: Jiang, F.
Publisher: name: National Research Council Canada
Year: 2016

description: To lower the cost of production of true-breeding double haploid lines used in wheat breeding.
description: Canadian Wheat Alliance (CWA) Open House, March 16, 2016, Saskatoon, Saskatchewan, Canada
title: Entwicklung eines Verfahrens zur Modellierung von Abhängigkeiten zwischen Modulen für die modulare Absicherung automatisierter Fahrfunktionen
Creators: name: Kohls, Svenja Katharina
Publisher: name: UNSPECIFIED
Year: 2022

description: Eine wesentliche Herausforderung beim automatisierten Fahren stellt die Gewährleistung der funktionalen Sicherheit dar. Die Entwicklung von Methoden zur Erbringung eines solchen validen Sicherheitsnachweises ist Teil des Forschungsprojekts UNICARagil. Im Rahmen dieses Projekts werden modulare und dienstorientierte automatisierte Fahrzeuge entwickelt, deren Architektur eine individuelle Erprobung und somit eine Abkehr von der Absicherung auf Gesamtsystemebene ermöglicht. Die individuelle Absicherung einzelner Module erfordert die Berücksichtigung der Abhängigkeiten zu anderen Modulen und zur Umgebung. In dieser Arbeit wird im ersten Schritt ein Verfahren zur Ermittlung und Darstellung von Abhängigkeiten hinsichtlich einer modularen Absicherung entwickelt. Dieses basiert auf einem Modellierungswerkzeug, welches für kritische Infrastrukturen entwickelt wurde. In einem iterativen Prozess wird die Systemarchitektur modelliert und das Abhängigkeitsnetz aufgebaut. Im zweiten Schritt dieser Arbeit wird ein Verfahren zur Definition von Testfällen auf Grundlage ermittelter Abhängigkeiten entwickelt, welches auf einem szenariobasierten Ansatz basiert. Mittels einer experten- und anforderungsbasierten Szenariogenerierung werden Testfälle für die ermittelten Abhängigkeiten erzeugt. Die Durchführung der Testfälle in der bestehenden Simulationsumgebung bestätigt die ermittelten Abhängigkeiten und deckt weitere unbekannte Abhängigkeiten auf.
Extremely Large EUV Late Phase of Solar Flares
Creators: name: Liu, Kai
name: Wang, Yuming
name: Zhang, Jie
name: Cheng, Xin
name: Liu, Rui
name: Shen, Chenglong
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The second peak in the Fe XVI 33.5 nm line irradiance observed during solar flares by Extreme ultraviolet Variability Experiment (EVE) is known as Extreme UltraViolet (EUV) late phase. Our previous paper (Liu et al. 2013) found that the main emissions in the late phase are originated from large-scale loop arcades that are closely connected to but different from the post flare loops (PFLs), and we also proposed that a long cooling process without additional heating could explain the late phase. In this paper, we define the extremely large late phase because it not only has a bigger peak in the warm 33.5 irradiance profile, but also releases more EUV radiative energy than the main phase. Through detailedly inspecting the EUV images from three point-of-view, it is found that, besides the later phase loop arcades, the more contribution of the extremely large late phase is from a hot structure that fails to erupt. This hot structure is identified as a flux rope, which is quickly energized by the flare reconnection and later on continuously produces the thermal energy during the gradual phase. Together with the late-phase loop arcades, the fail to erupt flux rope with the additional heating create the extremely large EUV late phase.
description: 9 figures
Male size of nest owners and sneakers in 17°C and 21°C mesocosms from Within-generation and transgenerational plasticity of mate choice in oceanic stickleback under climate change
Creators: name: Fuxjäger, Lukas
name: Wanzenböck, Sylvia
name: Ringler, Eva
name: K. Mathias Wegner
name: Ahnelt, Harald
name: Shama, Lisa N. S.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology

description: Bar chart showing male size of nest owners and sneakers in the two mesocosm temperatures, and table showing GLMM results for effects of male status, male temperature and mesocosm temperature on male size.
title: Improving genetic diversity in wheat: development of NAM resource
Creators: name: Sharpe, Andy
name: Yu, Bianyun
name: Zhang, Wentao
name: Gao, Peng
name: Sidbottom, Christine
name: Lokuruge, Prabath
name: Clarke, Carling
name: Cram, Dustin
name: Fobert, Pierre
name: Cuthbert, Richard
name: Knox, Ron
name: Pozniak, Curtis
Publisher: name: National Research Council Canada
Year: 2016

description: Canadian Wheat Alliance (CWA) Open House, March 16, 2016, Saskatoon, Saskatchewan, Canada
Mixed Stops and the ATLAS on-Z Excess
Creators: name: Collins, Jack H.
name: Dror, Jeff Asaf
name: Farina, Marco
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The ATLAS experiment has recently observed a 3-sigma excess in a channel with a leptonically decaying Z, jets, and ETmiss. It is tantalizing to interpret the signal as the first sign of a natural supersymmetric spectrum. We study such a possibility in a minimal model containing light stops and a neutralino LSP. The signal is characterized by a novel topology (compared to previous attempts) where the Z is emitted from a colored particle in the first step of a decay chain, namely t2 -> t1 Z which is characteristic of mixed stops. We show that the excess is compatible with a compressed stop spectrum and is not excluded by any other relevant search, finding some regions of parameter space with signal strength within 1-sigma of that measured by the ATLAS collaboration. In addition, we notice that the corresponding CMS search could be prone to background contamination in unexpected topologies of this kind.
description: 11 pages, 5 figures. v3: final revision with minor additions, matches the version published on PRD
title: New gene targets for drought and WUE in wheat
Creators: name: Datla, Raju
name: Wen, Rui
name: Babic, Vivijan
name: Venglat, Prakash
name: Xiang, Daoquan
name: Wang, Edwin
name: Cuthbert, Richard
Publisher: name: National Research Council Canada
Year: 2016

description: Discovery of signaling factors (SF) and their functions in drought and WUE (Water Use Efficient); Develop wheat lines with improved WUE.
description: Canadian Wheat Alliance (CWA) Open House, March 16, 2016, Saskatoon, Saskatchewan, Canada
AI-PRISM Project Launch Press Release
Creators: name: AI-PRISM Consortium
Publisher: name: Zenodo
Year: 2022
Subjects: Communication, Dissemination, Outreach, Press Release, Artificial Intelligence, Manufacturing

description: The consortium of AI-PRISM (AI-Powered human-centred Robot Interactions for Smart Manufacturing) is pleased to announce the launch of this joint initiative, granted by the European Commission under the Horizon Europe programme.
Theory of phonon dynamics in an ion trap
Creators: name: Dutta, T.
name: Mukherjee, M.
name: Sengupta, K.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Atomic Physics (physics.atom-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We develop a theory to address the non-equilibrium dynamics of phonons in a one-dimensional trapped ion system. We elaborate our earlier results obtained in Phys. Rev. Lett. {\bf 111}, 170406 (2013) to chart out the mechanism of dynamics-induced cooling and entanglement generation between phonons in these systems when subjected to a linear ramp protocol inducing site-specific tuning of on-site interactions between the phonons. We further extend these studies to non-linear ramps and periodic drive protocols and identify the optimal ramp protocol for minimal cooling and entanglement generation time. We qualitatively address the effect of noise arising out of fluctuation of the intensity of the laser used to generate entanglement and provide a detailed discussion of a realistic experimental setup which may serve as a test bed for our theory.
description: 10 pages and 11 figures
title: Fusarium Head Blight resistant Canadian wheat through genomics
Creators: name: Fobert, F.
name: Zhang, W.
name: Boyle, K.
name: Francis, T.
name: Gao, P.
name: Polley, B.
name: Jiang, F.
name: Wang, L.
name: Forseille, L.
name: Sharpe, A.
name: Fedak, G.
name: Djama, Z. Roblen
name: Cuthbert, R.
name: Knox, R.
name: DePauw, R.
name: Eudes, F.
name: Randhawa, H.
name: Graf, R.
name: Brule-Babel, A.
Publisher: name: National Research Council Canada
Year: 2016

description: Accelerate the production of Fusarium Head Blight (FHB) resistant wheat varieties; specifically to pursue potential new and native resistance from AAFC varieties FL62R1 and Emerson.
description: Canadian Wheat Alliance (CWA) Open House, March 16, 2016, Saskatoon, Saskatchewan, Canada
Intracellular delivery of an antisense oligonucleotide via endocytosis of a G protein-coupled receptor
Creators: name: Ming, Xin
name: Yan, Yongjun
name: Chen, Xiaoyuan
name: Alam, Md Rowshon
name: Juliano, Rudolph L.
name: Fisher, Michael
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Gastrin-releasing peptide receptor (GRPR), a member of the G protein-coupled receptor superfamily, has been utilized for receptor-mediated targeting of imaging and therapeutic agents; here we extend its use to oligonucleotide delivery. A splice-shifting antisense oligonucleotide was conjugated to a bombesin (BBN) peptide, and its intracellular delivery was tested in GRPR expressing PC3 cells stably transfected with a luciferase gene interrupted by an abnormally spliced intron. The BBN-conjugate produced significantly higher luciferase expression compared to unmodified oligonucleotide, and this increase was reversed by excess BBN peptide. Kinetic studies revealed a combination of saturable, receptor-mediated endocytosis and non-saturable pinocytosis for uptake of the conjugate. The Km value for saturable uptake was similar to the EC50 value for the pharmacological response, indicating that receptor-mediated endocytosis was a primary contributor to the response. Use of pharmacological and molecular inhibitors of endocytosis showed that the conjugate utilized a clathrin-, actin- and dynamin-dependent pathway to enter PC3 cells. The BBN-conjugate partially localized in endomembrane vesicles that were associated with Rab7 or Rab9, demonstrating that it was transported to late endosomes and the trans-golgi network. These observations suggest that the BBN-oligonucleotide conjugate enters cells via a process of GRPR mediated endocytosis followed by trafficking to deep endomembrane compartments.
A Study of Curation, Location and Temporality in Contemporary Art Fairs
Creators: name: Behrman, Pryle
Publisher: name: University of Westminster
Year: 2023

description: This PhD by Published Work critically analyses a series of five exhibitions curated by the author at London Art Fair between 2016-2020, which form the portfolio of projects within this thesis. Each exhibition explored notions of temporality and site, focusing on how these concepts are reframed and problematised by being examined within a contemporary art fair. The motivation for the projects stemmed from researching curated art shows from recent years that addressed notions of time and finding a lack of analysis in relation to how these might be affected by their location, which suggested a new field of enquiry. To address this area, the curatorial aim of each exhibition within the portfolio sought to test how differing conceptions of temporality – whether an artwork might be considered permanent or ephemeral, finished or unfinished, occurring now or in the past – might impact upon and be impacted by ideas of site – such as whether an artwork is physical or virtual, located within the art fair or situated elsewhere. The methodology that guided the portfolio of projects was transversal and brought together analytical systems from three differing areas of intellectual enquiry, combining a rhizomatic approach, which emphasised the interconnected nature of the exhibitions, with methods derived from phenomenology (to promote a questioning of received definitions relating to location and time) and institutional critique (to critically engage with the art fair setting). The outcomes from the portfolio support the contention that curatorial practice, temporality and site are not discrete elements within a contemporary art fair environment, but rather forces that are wholly interdependent. Additionally, the physical and temporal boundaries of the exhibited artworks, and the exhibition as a whole, might be considered problematic to define with any fixity. This PhD thesis proposes a twofold contribution to new knowledge as a result: firstly, that a fuller appreciation of the interaction between curation, setting and temporality within curated exhibitions at contemporary art fairs requires a conceptualisation of these three factors as being a single entity; secondly, that this entity can encompass, without contradiction, multiple definitions of both location and temporality.
Molecular gas in star-forming galaxies of the intermediate redshift cluster Zw Cl0024+1652
Creators: name: Sánchez-Portal, Miguel
name: Bongiovanni, Angel
name: Cepa, Jordi
name: Pérez García, Ana M.
name: Padilla-Torres, Carmen P.
name: González Serrano, J. Ignacio
name: Pintos-Castro, Irene
name: Pérez-Martínez, Ricardo
name: Cruz-González, Irene
name: Negrete, Alenka
name: Beyoro-Amado, Zeleke
name: Povic, Mirjana
Publisher: name: Zenodo
Year: 2022

description: We present preliminary results from a survey of cold gas in an intermediate-redshift cluster, Zw Cl0024.1+1652 at z = 0.395, using the EMIR instrument at the IRAM-30m telescope, Pico Veleta observatory, Sierra Nevada, Spain. We observed the CO 2-1 and 1-0 transitions in a sample of seven star-forming galaxies drawn out of the GLACE catalogue of H-alpha+[NII] emission-line galaxies. These galaxies have been chosen to be bright in far-IR and to span a wide range of local densities/cluster-centric distances. We have derived the L'_CO luminosity (tracing the amount of cold gas available for star formation) and combined these data with the L_TIR data (tracing the SFR) derived by our team, and with additional CO and FIR data from literature to study how the amount of cold gas in an intermediate-redshift cluster relates to the SFR and cluster-centric distance. The results suggest that, at a given SFR, the reservoir of cold gas is smaller in cluster galaxies. Furthermore, there are also hints that the amount of cold gas increases with the cluster-centric distance, hence pointing to an environmental dependency.
THE PRACTICE OF CONFLICT MANAGEMENT STYLES: THE CASE OF ARTS MEDIA PRODUCTION
Creators: name: LENSA TESFAYE LEMMA
Publisher: name: Zenodo
Year: 2018

description: It is almost given that conflict is inevitable in the relation between individuals and groups. Workplaces are not exceptions in this regard. Yet, the occurrence of conflict by itself is no more considered a problem as far as it is managed effectively. In line with this, this study explored the practices of conflict management styles at Arts Media Production. In doing so, attempt has been made to examine the different sorts of interpersonal and interdepartmental conflicts that frequently happen in the operation process of the project and how they are managed. As a result, the findings of the study revealed that the major interpersonal and interdepartmental conflicts that occur in the project are the ones that are structural and socio-cognitive driven conflicts. It was further found out that the project managers tend to apply mainly accommodating and avoiding conflict management styles. However, avoiding have turned out to make employees dissatisfied which resulted in a high staff turnover. This in turn affected the overall performance of the project negatively
Additional file 1 of The relation between obesity and breast cancer risk in women by considering menstruation status and geographical variations: a systematic review and meta-analysis
Creators: name: Dehesh, Tania
name: Fadaghi, Shohreh
name: Seyedi, Mehrnaz
name: Abolhadi, Elham
name: Ilaghi, Mehran
name: Shams, Parisa
name: Ajam, Fatemeh
name: Mosleh-Shirazi, Mohammad Amin
name: Dehesh, Paria
Publisher: name: figshare
Year: 2023
Subjects: subject: Biotechnology
classificationCode: 19999
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 1.
title: Genetic improvement of photosynthetic efficiency in wheat
Creators: name: Datla, Raju
name: Babic, Vivijan
name: Venglat, Prakash
name: Xiang, Daoquan
name: Wen, Rui
name: Wang, Edwin
name: Cuthbert, Richard
name: Singh, Jas
name: Pozniak, Curtis
name: Reynolds, Matthew
name: Molero, Gemma
Publisher: name: National Research Council Canada
Year: 2016

description: Identify and characterize new gene targets (GT) involved in photosynthetic efficiency.
description: Canadian Wheat Alliance (CWA) Open House, March 16, 2016, Saskatoon, Saskatchewan, Canada
MapSplice: Accurate mapping of RNA-seq reads for splice junction discovery
Creators: name: He, Xiaping
name: Singh, Darshan
name: MacLeod, James N.
name: Mieczkowski, Piotr
name: Zeng, Zheng
name: Wang, Kai
name: Liu, Jinze
name: Huang, Yan
name: Perou, Charles M.
name: Coleman, Stephen J.
name: Chiang, Derek Y.
name: Grimm, Sara A.
name: Prins, Jan F.
name: Savich, Gleb L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The accurate mapping of reads that span splice junctions is a critical component of all analytic techniques that work with RNA-seq data. We introduce a second generation splice detection algorithm, MapSplice, whose focus is high sensitivity and specificity in the detection of splices as well as CPU and memory efficiency. MapSplice can be applied to both short (<75 bp) and long reads (≥75 bp). MapSplice is not dependent on splice site features or intron length, consequently it can detect novel canonical as well as non-canonical splices. MapSplice leverages the quality and diversity of read alignments of a given splice to increase accuracy. We demonstrate that MapSplice achieves higher sensitivity and specificity than TopHat and SpliceMap on a set of simulated RNA-seq data. Experimental studies also support the accuracy of the algorithm. Splice junctions derived from eight breast cancer RNA-seq datasets recapitulated the extensiveness of alternative splicing on a global level as well as the differences between molecular subtypes of breast cancer. These combined results indicate that MapSplice is a highly accurate algorithm for the alignment of RNA-seq reads to splice junctions. Software download URL: http://www.netlab.uky.edu/p/bioinfo/MapSplice.
Supplemental Material from Magnetoliposomes as model for signal transmission.
Creators: name: G. R. Barreto
name: C. Kawai
name: A. Tofanello
name: A. A. R. Neves
name: J. C. Araujo-Chaves
name: E. Belleti
name: A. J. C. Lanfredi
name: F. N. Crespilho
name: I. L. NANTES-CARDOSO
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Supramolecular Chemistry
subject: 30699 Physical Chemistry not elsewhere classified
subject: FOS: Chemical sciences
subject: 100799 Nanotechnology not elsewhere classified
subject: FOS: Nanotechnology

description: Supplemental Material RSOS revised
Spatial shape of avalanches in the Brownian force model
Creators: name: Thiery, Thimothée
name: Doussal, Pierre Le
name: Wiese, Kay Jörg
Publisher: name: arXiv
Year: 2015
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We study the Brownian force model (BFM), a solvable model of avalanche statistics for an interface, in a general discrete setting. The BFM describes the overdamped motion of elastically coupled particles driven by a parabolic well in independent Brownian force landscapes. Avalanches are defined as the collective jump of the particles in response to an arbitrary monotonous change in the well position (i.e. in the applied force). We derive an exact formula for the joint probability distribution of these jumps. From it we obtain the joint density of local avalanche sizes for stationary driving in the quasi-static limit near the depinning threshold. A saddle-point analysis predicts the spatial shape of avalanches in the limit of large aspect ratios for the continuum version of the model. We then study fluctuations around this saddle point, and obtain the leading corrections to the mean shape, the fluctuations around the mean shape and the shape asymmetry, for finite aspect ratios. Our results are finally confronted to numerical simulations.
description: 41 pages, 16 figures
Telomeric circles are abundant in the stn1-M1 mutant that maintains its telomeres through recombination
Creators: name: Griffith, Jack D.
name: McEachern, Michael J.
name: Cesare, Anthony J.
name: Basenko, Evelina Y.
name: Iyer, Shilpa
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Some human cancers maintain their telomeres using the alternative lengthening of telomeres (ALT) mechanism; a process thought to involve recombination. Different types of recombinational telomere elongation pathways have been identified in yeasts. In senescing yeast telomerase deletion (ter1-Δ) mutants with very short telomeres, it has been hypothesized that copying a tiny telomeric circle (t-circle) by a rolling circle mechanism is the key event in telomere elongation. In other cases more closely resembling ALT cells, such as the stn1-M1 mutant of Kluyveromyces lactis, the telomeres appear to be continuously unstable and routinely reach very large sizes. By employing two-dimensional gel electrophoresis and electron microscopy, we show that stn1-M1 cells contain abundant double stranded t-circles ranging from ∼100 to 30 000 bp in size. We also observed small single-stranded t-circles, specifically composed of the G-rich telomeric strand and tailed circles resembling rolling circle replication intermediates. The t-circles most likely arose from recombination events that also resulted in telomere truncations. The findings strengthen the possibility that t-circles contribute to telomere maintenance in stn1-M1 and ALT cells.
Long-time behavior of a finite volume discretization for a fourth order diffusion equation
Creators: name: Maas, Jan
name: Matthes, Daniel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Analysis of PDEs (math.AP)
subject: Numerical Analysis (math.NA)
subject: Probability (math.PR)
subject: FOS: Mathematics

description: We consider a non-standard finite-volume discretization of a strongly non-linear fourth order diffusion equation on the $d$-dimensional cube, for arbitrary $d \geq 1$. The scheme preserves two important structural properties of the equation: the first is the interpretation as a gradient flow in a mass transportation metric, and the second is an intimate relation to a linear Fokker-Planck equation. Thanks to these structural properties, the scheme possesses two discrete Lyapunov functionals. These functionals approximate the entropy and the Fisher information, respectively, and their dissipation rates converge to the optimal ones in the discrete-to-continuous limit. Using the dissipation, we derive estimates on the long-time asymptotics of the discrete solutions. Finally, we present results from numerical experiments which indicate that our discretization is able to capture significant features of the complex original dynamics, even with a rather coarse spatial resolution.
description: 27 pages, minor changes
Transport Through a Correlated Interface: Auxiliary Master Equation Approach
Creators: name: Titvinidze, Irakli
name: Dorda, Antonius
name: von der Linden, Wolfgang
name: Arrigoni, Enrico
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We present improvements of a recently introduced numerical method [Arrigoni etal, Phys. Rev. Lett. 110, 086403 (2013)] to compute steady state properties of strongly correlated electronic systems out of equilibrium. The method can be considered as a non-equilibrium generalization of exact diagonalization based dynamical mean-field theory (DMFT). The key modification for the non-equilibrium situation consists in addressing the DMFT impurity problem within an auxiliary system consisting of the correlated impurity, $N_b$ uncorrelated bath sites and two Markovian environments (sink and reservoir). Algorithmic improvements in the impurity solver allow to treat efficiently larger values of $N_b$ than previously in DMFT. This increases the accuracy of the results and is crucial for a correct description of the physical behavior of the system in the relevant parameter range including a semi-quantitative description of the Kondo regime. To illustrate the approach we consider a monoatomic layer of correlated orbitals, described by the single-band Hubbard model, attached to two metallic leads. The non-equilibrium situation is driven by a bias-voltage applied to the leads. For this system, we investigate the spectral function and the steady state current-voltage characteristics in the weakly as well as in the strongly interacting limit. In particular we investigate the non-equilibrium behavior of quasi-particle excitations within the Mott gap of the correlated layer. We find for low bias voltage Kondo like behavior in the vicinity of the insulating phase. In particular we observe a splitting of the Kondo resonance as a function of the bias voltage.
description: 10 pages 9 figures
we change this title bruh - snapshot
Creators: name: Amazurek
name: Gosia Wolniewicz
Publisher: name: Zenodo
Year: 2023
Subjects: subject: http://eurovoc.europa.eu/3291
subject: http://eurovoc.europa.eu/4107
subject: http://eurovoc.europa.eu/685
subject: http://eurovoc.europa.eu/3931

description: Research Object we change this title bruh - snapshot
description: Research Object in rohub2020: https://w3id.org/ro-id-dev/d9a877c9-9ca2-4498-ba09-7d97d719991f
The mechanism and control of DNA transfer by the conjugative relaxase of resistance plasmid pCU1
Creators: name: Cheng, Yuan
name: Nash, Rebekah Potts
name: Redinbo, Matthew R.
name: Lujan, Scott A.
name: Habibi, Sohrab
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Bacteria expand their genetic diversity, spread antibiotic resistance genes, and obtain virulence factors through the highly coordinated process of conjugative plasmid transfer (CPT). A plasmid-encoded relaxase enzyme initiates and terminates CPT by nicking and religating the transferred plasmid in a sequence-specific manner. We solved the 2.3 Å crystal structure of the relaxase responsible for the spread of the resistance plasmid pCU1 and determined its DNA binding and nicking capabilities. The overall fold of the pCU1 relaxase is similar to that of the F plasmid and plasmid R388 relaxases. However, in the pCU1 structure, the conserved tyrosine residues (Y18,19,26,27) that are required for DNA nicking and religation were displaced up to 14 Å out of the relaxase active site, revealing a high degree of mobility in this region of the enzyme. In spite of this flexibility, the tyrosines still cleaved the nic site of the plasmid’s origin of transfer, and did so in a sequence-specific, metal-dependent manner. Unexpectedly, the pCU1 relaxase lacked the sequence-specific DNA binding previously reported for the homologous F and R388 relaxase enzymes, despite its high sequence and structural similarity with both proteins. In summary, our work outlines novel structural and functional aspects of the relaxase-mediated conjugative transfer of plasmid pCU1.
Supplemental Material from Magnetoliposomes as model for signal transmission
Creators: name: G. R. Barreto
name: C. Kawai
name: A. Tofanello
name: A. A. R. Neves
name: J. C. Araujo-Chaves
name: E. Belleti
name: A. J. C. Lanfredi
name: F. N. Crespilho
name: I. L. NANTES-CARDOSO
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Supramolecular Chemistry
subject: 30699 Physical Chemistry not elsewhere classified
subject: FOS: Chemical sciences
subject: 100799 Nanotechnology not elsewhere classified
subject: FOS: Nanotechnology

description: Supplemental Material RSOS revised
title: Markers for drought tolerant wheat
Creators: name: Cutler, Adrian
name: Feurtado, Allan
name: Huang, Diaquing
name: Smith, Mark
name: Koh, Kevin
name: Cram, Dustin
name: Barber, Carla
name: Knox, Ron
name: Ruan, Yuefeng
name: Cuthbert, Richard
Publisher: name: National Research Council Canada
Year: 2016

description: Find stress-related genetic markers to be used in plant breeding.
description: Canadian Wheat Alliance (CWA) Open House, March 16, 2016, Saskatoon, Saskatchewan, Canada
O Coral Comunitário como Dispositivo de Promoção da Saúde Mental: Manual para Implementação
Creators: name: Barros, Leonardo Haddad da Costa
name: Pio, Danielle Abdel Massih
name: Bettini, Roseli Vernasque
Publisher: name: Zenodo
Year: 2022
Subjects: Música, Saúde Mental, Atenção Primária à Saúde, Pandemias

description: A presente proposta é um manual para a implementação de um grupo de coral comunitário como dispositivo de promoção de saúde mental. O manual é fruto da pesquisa de mestrado intitulada "Repercussões de um coral comunitário como dispositivo de promoção de saúde mental". A pesquisa demonstrou resultados satisfatórios a partir da implementação desse tipo de grupo no território, especificamente na abrangência da Atenção Primária à Saúde (APS). Os resultados do estudo apontaram que o coral comunitário contribuiu para o fomento/surgimento da sensação de pertencimento, altruísmo e ocupação por meio de um cuidado humanizado e inclusivo. Favoreceu ainda a autonomia, a criação e o fortalecimento de vínculos, a autoestima e a cognição. Mediado pela música, esse grupo também foi capaz de evocar memórias pela via afetiva, possibilitando novas oportunidades de compreensão. As interações proporcionadas pelo coral favoreceram, ainda, a comunicação, o que repercutiu de maneira geral nas interrelações dos usuários. O protagonismo e a autonomia também se destacaram a partir do convívio entre pares e com os profissionais de saúde. Estes desempenharam um papel acolhedor e inclusivo, favorecendo ainda mais a formação de redes de apoio. O grupo passou a ser considerado em Projetos Terapêuticos Singulares (PTS) do CAPS II (transtornos severos e persistentes) do município de Marília-SP, podendo ser ainda uma ferramenta de reabilitação psicossocial.
description: {"references": ["Barros, Pio e Bettini (2022)"]}
Additional file 1 of Identifying domains of health-related quality of life: the perspective of individuals with low back pain
Creators: name: Eilayyan, O
name: Gogovor, A
name: Zidarov, D
name: Mayo, N
name: Ahmed, S
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Supplementary Material 1
O Coral Comunitário como Dispositivo de Promoção da Saúde Mental: Manual para Implementação
Creators: name: Barros, Leonardo Haddad da Costa
name: Pio, Danielle Abdel Massih
name: Bettini, Roseli Vernasque
Publisher: name: Zenodo
Year: 2022
Subjects: Música, Saúde Mental, Atenção Primária à Saúde, Pandemias.

description: A presente proposta é um manual para a implementação de um grupo de coral comunitário como dispositivo de promoção de saúde mental. O manual é fruto da pesquisa de mestrado intitulada "Repercussões de um coral comunitário como dispositivo de promoção de saúde mental", que obteve resultados satisfatórios a partir da implementação desse tipo de grupo no território, especificamente na abrangência da Atenção Primária à Saúde (APS).
description: {"references": ["Barros, Pio e Bettini (2022)"]}
we change this title bruh - snapshot
Creators: name: Gosia Wolniewicz
name: Amazurek
Publisher: name: Zenodo
Year: 2023
Subjects: subject: http://eurovoc.europa.eu/3291
subject: http://eurovoc.europa.eu/4107
subject: http://eurovoc.europa.eu/685
subject: http://eurovoc.europa.eu/3931

description: Research Object we change this title bruh - snapshot
description: Research Object in rohub2020: https://w3id.org/ro-id-dev/7cb12358-f576-46be-bb84-62afd88f43fd
O Coral Comunitário como Dispositivo de Promoção da Saúde Mental: Manual para Implementação
Creators: name: Barros, Leonardo Haddad da Costa
name: Pio, Danielle Abdel Massih
name: Bettini, Roseli Vernasque
Publisher: name: Zenodo
Year: 2022
Subjects: Música, Saúde Mental, Atenção Primária à Saúde, Pandemias.

description: A presente proposta é um manual para a implementação de um grupo de coral comunitário como dispositivo de promoção de saúde mental. O manual é fruto da pesquisa de mestrado intitulada "Repercussões de um coral comunitário como dispositivo de promoção de saúde mental". A pesquisa demonstrou resultados satisfatórios a partir da implementação desse tipo de grupo no território, especificamente na abrangência da Atenção Primária à Saúde (APS). Os resultados do estudo apontaram que o coral comunitário contribuiu para o fomento/surgimento da sensação de pertencimento, altruísmo e ocupação por meio de um cuidado humanizado e inclusivo. Favoreceu ainda a autonomia, a criação e o fortalecimento de vínculos, a autoestima e a cognição. Mediado pela música, esse grupo também foi capaz de evocar memórias pela via afetiva, possibilitando novas oportunidades de compreensão. As interações proporcionadas pelo coral favoreceram, ainda, a comunicação, o que repercutiu de maneira geral nas interrelações dos usuários. O protagonismo e a autonomia também se destacaram a partir do convívio entre pares e com os profissionais de saúde. Estes desempenharam um papel acolhedor e inclusivo, favorecendo ainda mais a formação de redes de apoio. O grupo passou a ser considerado em Projetos Terapêuticos Singulares (PTS) do CAPS II (transtornos severos e persistentes) do município de Marília-SP, podendo ser ainda uma ferramenta de reabilitação psicossocial.
description: {"references": ["Barros, Pio e Bettini (2022)"]}
Direct and indirect signals of natural composite Higgs models
Creators: name: Niehoff, Christoph
name: Stangl, Peter
name: Straub, David M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present a comprehensive numerical analysis of a four-dimensional model with the Higgs as a composite pseudo-Nambu-Goldstone boson that features a calculable Higgs potential and protective custodial and flavour symmetries to reduce electroweak fine-tuning. We employ a novel numerical technique that allows us for the first time to study constraints from radiative electroweak symmetry breaking, Higgs physics, electroweak precision tests, flavour physics, and direct LHC bounds on fermion and vector boson resonances in a single framework. We consider four different flavour symmetries in the composite sector, one of which we show to not be viable anymore in view of strong precision constraints. In the other cases, all constraints can be passed with a sub-percent electroweak fine-tuning. The models can explain the excesses recently observed in $WW$, $WZ$, $Wh$ and $\ell^+\ell^-$ resonance searches by ATLAS and CMS and the anomalies in angular observables and branching ratios of rare semi-leptonic $B$ decays observed by LHCb. Solving the $B$ physics anomalies predicts the presence of a dijet or $t\bar t$ resonance around 1 TeV just below the sensitivity of LHC run 1. We discuss the prospects to probe the models at run 2 of the LHC. As a side product, we identify several gaps in the searches for vector-like quarks at hadron colliders, that could be closed by reanalyzing existing LHC data.
description: 74 pages, 21 figures. v2: references added, discussion in 3.2.6 extended