cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Which solar neutrino data favour the LMA solution?
Creators: name: Strumia, Alessandro
name: Cattadori, Carla
name: Ferrari, Nicola
name: Vissani, Francesco
Publisher: name: arXiv
Year: 2002
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Assuming neutrino oscillations, global analyses of solar data find that the LOW solution is significantly disfavoured, leaving LMA as the best solution. But the preference for LMA rests on three weak hints: the spectrum of earth matter effects (Super-Kamiokande sees an overall day/night asymmetry only at 1 sigma), the Cl rate (but LMA and LOW predictions are both above the measured value), the Ga rate (newer data decrease towards the LOW predictions both in GNO and SAGE). Only new data will tell us if LMA is the true solution.
description: 4 pages, 2 figures
Oestrogenic regulation of lncRNA at enhancer regions
Creators: name: Cathcart, Paul Lewis
Publisher: name: Imperial College London
Year: 2018

description: Breast cancer is the commonest form of female malignancy with oestrogen receptor positive breast cancer comprising the majority of cases. Despite drastic improvement in treatment over the years, there still is a rising incidence with a significant recurrence rate despite optimal therapy. The molecular biology of cancer cells has advanced rapidly with the advent of genome-wide, high-throughput analytic technologies, revealing that eukaryotic cells are extensively transcribed. This has led to the discovery of a large variety of non-coding RNA (ncRNA) with unknown function. A subset of these ncRNA are transcribed at enhancer regions called enhancer RNAs (eRNA) and have demonstrated importance in transcriptional regulation and cellular function. eRNA are typically located in the nucleus and are monoexonic. By using publicly available GRO-seq, CHIP-seq and our RNA-seq, we identify several eRNAs with multiple exons and isoforms that can be found within the nucleus and cytoplasm. Understanding their function, particularly in the cytoplasm, could lead to the development of future therapies and biomarkers. We have found that these identified eRNAs can be detected by real-time qPCR and increase with oestradiol treatment, with one pair of bidirectionally transcribed eRNAs being close to the gene CCND1. Knockdown of these eRNAs causes a significant reduction in cell growth without any effect on neighbouring genes. Overexpression of eRNAs appear to have no effect on the neighbouring genes and cell growth. Using publicly available data and ribosome profiling experiments, we can confirm that the eRNA are not protein coding but there is potential that they may produce previously unknown small peptides. Finally, we demonstrate by mass spectrometry that one particular eRNA may interact with SUB1. These findings provide a novel insight into uncharacteristic eRNAs that are spliced and located in the cytoplasm and nucleus. Despite having such low expression, they produce significant effects within the cell.
Excess TPX2 Interferes with Microtubule Disassembly and Nuclei Reformation at Mitotic Exit
Creators: name: Naso, Francesco D.
name: Sterbini, Valentina
name: Crecca, Elena
name: Asteriti, Italia A.
name: Russo, Alessandra D.
name: Giubettini, Maria
name: Cundari, Enrico
name: Lindon, Catherine
name: Rosa, Alessandro
name: Guarguaglini, Giulia
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: TPX2
mitosis
spindle
nuclear envelope

description: The microtubule-associated protein TPX2 is a key mitotic regulator that contributes through distinct pathways to spindle assembly. A well-characterised function of TPX2 is the activation, stabilisation and spindle localisation of the Aurora-A kinase. High levels of TPX2 are reported in tumours and the effects of its overexpression have been investigated in cancer cell lines, while little is known in non-transformed cells. Here we studied TPX2 overexpression in hTERT RPE-1 cells, using either the full length TPX2 or a truncated form unable to bind Aurora-A, to identify effects that are dependent—or independent—on its interaction with the kinase. We observe significant defects in mitotic spindle assembly and progression through mitosis that are more severe when overexpressed TPX2 is able to interact with Aurora-A. Furthermore, we describe a peculiar, and Aurora-A-interaction-independent, phenotype in telophase cells, with aberrantly stable microtubules interfering with nuclear reconstitution and the assembly of a continuous lamin B1 network, resulting in daughter cells displaying doughnut-shaped nuclei. Our results using non-transformed cells thus reveal a previously uncharacterised consequence of abnormally high TPX2 levels on the correct microtubule cytoskeleton remodelling and G1 nuclei reformation, at the mitosis-to-interphase transition.
Livelihood diversification strategies in the Himalayas
Creators: name: Rahut, Dil Bahadur
name: Scharf, Maja Micevska
name: Rahut, Dil Bahadur
name: Scharf, Maja Micevska
Publisher: name: Unknown
Year: 2012
Subjects: subject: Community/Rural/Urban Development
subject: Consumer/Household Economics
subject: International Development
subject: Himalayas
subject: livelihood diversification
subject: non-farm employment
subject: rural households.

description: This article examines livelihood diversification strategies of rural households using survey data from the Himalayas. We present and explore an analytical framework that yields different activity choices as optimal solutions to a simple utility maximization problem. By classifying the range of activities of rural households into a few distinct categories based on their profitability and by considering portfolios of farm and nonfarm activities, we provide novel insights into diversification behaviour of rural households. The evidence shows that while the poor are mainly agricultural labourers and work in the low-return non-farm sector, the better-off diversify in high-return nonfarm activities. As expected, we find strong evidence that education plays a major role in accessing more remunerative non-farm employment. A somewhat less intuitive finding is that larger household size is associated with higher probability of diversification into the high-return non-farm sector. The finding that the farm size is not a constraint to diversification in lucrative non-farm employment is also surprising. Geographical location plays a role in diversification behaviour of rural households indicating the importance of local context.
Manipulation of macrophage programmed cell death pathways by enteropathogenic Escherichia coli
Creators: name: Goddard, Philippa Jane
Publisher: name: Imperial College London
Year: 2018

description: Enteropathogenic Escherichia coli (EPEC) is a human-restricted, clinically significant diarrhoeagenic pathogen that colonises the gut mucosa of hosts via the formation of characteristic attaching and effacing (A/E) lesions. To establish infection and cause disease, EPEC subverts a range of host cell processes through the injection of a suite of bacterial effector proteins into host cells via a Type 3 Secretion System (T3SS). EPEC virulence is critically reliant on the T3SS-delivered Translocated intimin receptor (Tir), which triggers actin polymerisation at the bacterial attachment site in intestinal epithelial cells. However, the manner in which EPEC effector proteins activate and subvert signalling pathways in human immune cells, such as macrophages, remains to be established. During infection the innate immune compartment of the intestinal mucosa plays a pivotal role in antimicrobial immunity, and activation of inflammasome signalling pathways is central to bacterial clearance. This has been established in vivo using the model A/E pathogen Citrobacter rodentium. Interestingly, although evolutionarily closely related to the enteric pathogens Citrobacter, Salmonella and Shigella, the EPEC T3SS needle and flagellin proteins evade detection by inflammasomes. Currently EPEC-induced inflammasome activation in human macrophages is poorly understood. Here I show that infection of human primary macrophages with EPEC rapidly induces NLRP3-inflammasome-driven pyroptosis in a strictly Tir-dependent manner. Mechanistically, Tir-induced actin polymerisation, either via Tir tyrosine phosphorylation and the Nck-N-WASP-ARP2/3 actin polymerisation pathway, or through Tir and the Nck-mimicking effector TccP, stimulated rapid caspase-4-dependent inflammasome responses. Notably, in contrast to caspase-4-driven pyroptosis induced by non-pathogenic E. coli or cytosolic LPS, both pyroptosis and cytokine processing in response to EPEC infection required NLRP3, ASC and caspase-1, and occurred independently of pannexin-1. This study identifies a surprising and indispensable role for both human caspase-4 and NLRP3 in detecting EPEC, and an essential role for pathological actin polymerisation by a bacterial effector in inflammasome activation.
Qualitative understanding of the sign of t' asymmetry in the extended t-J Model and relevance for pairing properties
Creators: name: Martins, G. B.
name: Xavier, J. C.
name: Arrachea, L.
name: Dagotto, E.
Publisher: name: arXiv
Year: 2001
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Numerical calculations illustrate the effect of the sign of the next nearest-neighbor hopping term t' on the 2-hole properties of the t-t'-J model. Working mainly on 2-leg ladders, in the -1.0 < t'/t < 1.0 regime, it is shown that introducing t' in the t-J model is equivalent to effectively renormalizing J, namely t' negative (positive) is equivalent to an effective t-J model with smaller (bigger) J. This effect is present even at the level of a 2x2 plaquette toy model, and was observed also in calculations on small square clusters. Analyzing the transition probabilities of a hole-pair in the plaquette toy model, it is argued that the coherent propagation of such hole-pair is enhanced by a constructive interference between both t and t' for t'>0. This interference is destructive for t'<0.
description: 5 pages, 4 figures, to appear in PRB as a Rapid Communication
Combining film design and spectroscopic strategies to elucidate triplet dynamics in molecular systems
Creators: name: Lubert-Perquel, Daphne
Publisher: name: Imperial College London
Year: 2019

description: Optimising molecular systems for optoelectronic applications requires a deep understanding of the exciton dynamics in such systems. Pentacene is an archetypal organic semiconductor, with multiple device applications depending on molecular aggregation and orientation within the structure. Isolated pentacene molecules within crystals are used for the room-temperature MASER (a device analogous to the laser for microwave amplification by stimulated emission of radiation) but limitations remain due to relaxation processes and heating effects. Aggregated systems undergo singlet fission, the mechanism whereby two triplet excitons are generated from a single photon absorption. This process is of interest to build efficient triplet-harvesting layers for organic photovoltaic applications as it overcomes the thermodynamic limitations of these devices. This project designs a thin film system that varies the concentration of pentacene to investigate the exciton properties and dynamics as a function of microstructure and molecular configuration. Electron paramagnetic resonance spectroscopy is used to identify the spin species in the pentacene films and the spectral signatures of the free and coupled triplets for different configurations of dimers are identified with distinct kinetic parameters. To explain these differing dynamics, DFT calculations are carried out alongside temperature-dependent measurements to obtain the activation energies of the photoexcited processes. To obtain a complete overview of the dynamics of this molecular system, ultra-fast transient absorption spectroscopy was also employed to study the early-time processes. The intermediate states involved in singlet fission are observed and are tentatively assigned according to the molecular configuration of the pentacene pairs. This project provides a methodology of film design and characterisation that can be extended to other compatible host-dopant systems used in optoelectronic and spintronic devices. Consequently, not only does this work extend our understanding of the photoexcited mechanisms in pentacene, it also provides a template for investigations of similar molecular systems.
Visible Branes with Negative Tension in Heterotic M-Theory
Creators: name: Donagi, Ron Y.
name: Khoury, Justin
name: Ovrut, Burt A.
name: Steinhardt, Paul J.
name: Turok, Neil
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Astrophysics (astro-ph)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: It is shown that there exist large classes of BPS vacua in heterotic M-theory which have negative tension on the visible orbifold plane, positive tension on the hidden plane and positive tension, physical five-branes in the bulk space. Explicit examples of such vacua are presented. Furthermore, it is demonstrated that the ratio, beta/|alpha|, of the bulk five-brane tension to the visible plane tension can, for several large classes of such vacua, be made arbitrarily small. Hence, it is straightforward to find vacua with the properties required in the examples of the Ekpyrotic theory of cosmology - a visible brane with negative tension and beta/|alpha| small. This contradicts recent claims in the literature.
description: 30 pages
Unequal rapidity correlators in the dilute limit of JIMWLK
Creators: name: Lappi, Tuomas
name: Ramnath, Andrecia
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We study unequal rapidity correlators in the stochastic Langevin picture of Jalilian-Marian-Iancu-McLerran-Weigert-Leonidov-Kovner (JIMWLK) evolution in the Color Glass Condensate effective field theory. We discuss a diagrammatic interpretation of the long-range correlators. By separately evolving the Wilson lines in the direct and complex conjugate amplitudes, we use the formalism to study two-particle production at large rapidity separations. We show that the evolution between the rapidities of the two produced particles can be expressed as a linear equation, even in the full nonlinear limit. We also show how the Langevin formalism for two-particle correlations reduces to a BFKL picture in the dilute limit and in momentum space, providing an interpretation of BFKL evolution as a stochastic process for color charges.
description: 18 pages, 1 figure
Comparative Cell Surface Proteomic Analysis of the Primary Human T Cell and Monocyte Responses to Type I Interferon
Creators: name: Soday, Lior
name: Potts, Martin
name: Hunter, Leah M.
name: Ravenhill, Benjamin J.
name: Houghton, Jack W.
name: Williamson, James C.
name: Antrobus, Robin
name: Wills, Mark R.
name: Matheson, Nicholas J.
name: Weekes, Michael P.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: subject: Immunology
subject: FOS: Clinical medicine
subject: type I interferon (IFN)
subject: leukocytes
subject: quantitative proteomics
subject: cell surface
subject: antiviral restrictin
subject: monocyte
subject: T cell
subject: plasma membrane

description: The cellular response to interferon (IFN) is essential for antiviral immunity, IFN-based therapy and IFN-related disease. The plasma membrane (PM) provides a critical interface between the cell and its environment, and is the initial portal of entry for viruses. Nonetheless, the effect of IFN on PM proteins is surprisingly poorly understood, and has not been systematically investigated in primary immune cells. Here, we use multiplexed proteomics to quantify IFNα2a-stimulated PM protein changes in primary human CD14+ monocytes and CD4+ T cells from five donors, quantifying 606 and 482 PM proteins respectively. Comparison of cell surface proteomes revealed a remarkable invariance between donors in the overall composition of the cell surface from each cell type, but a marked donor-to-donor variability in the effects of IFNα2a. Furthermore, whereas only 2.7% of quantified proteins were consistently upregulated by IFNα2a at the surface of CD4+ T cells, 6.8% of proteins were consistently upregulated in primary monocytes, suggesting that the magnitude of the IFNα2a response varies according to cell type. Among these differentially regulated proteins, we found the viral target Endothelin-converting enzyme 1 (ECE1) to be an IFNα2a-stimulated protein exclusively upregulated at the surface of CD4+ T cells. We therefore provide a comprehensive map of the cell surface of IFNα2a-stimulated primary human immune cells, including previously uncharacterized interferon stimulated genes (ISGs) and candidate antiviral factors.
Additional file 11 of E. urophylla × E. grandis high-quality genome and comparative genomics provide insights on evolution and diversification of eucalyptus
Creators: name: Shen, Chao
name: Li, Limei
name: Ouyang, Lejun
name: Su, Min
name: Guo, Kexin
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 11
On Schwarzschild's Topology in Brane-Worlds
Creators: name: Monte, Edmundo M.
name: Maia, M. D.
Publisher: name: arXiv
Year: 2002
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: The topological structure of Schwarzschild's space-time and its maximal analytic extension are investigated in context of brane-worlds. Using the embedding coordinates, these geometries are seen as different states of the evolution of a single brane-world. Comparing the topologies and the embeddings it is shown that this evolution must be followed by a signature change in the bulk.
description: 6 pages
New immunological potential markers for triple negative breast cancer: IL18R1, CD53, TRIM, Jaw1, LTB, PTPRCAP
Creators: name: Marchetti, Paolo
name: Antonov, Alexey
name: Anemona, Lucia
name: Vangapandou, Chaitania
name: Montanaro, Manuela
name: Botticelli, Andrea
name: Mauriello, Alessandro
name: Melino, Gerry
name: Catani, M. Valeria
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Research
Triple negative breast cancer
IL18R1
CD53
TRIM
Jaw1
LTB
PTPRCAP
Prognostic markers
Precision oncology
Cancer immunity

description: Abstract: Breast cancer (BC) is the second leading cause of cancer death in women worldwide, and settings of specific prognostic factors and efficacious therapies are made difficult by phenotypic heterogeneity of BC subtypes. Therefore, there is a current urgent need to define novel predictive genetic predictors that may be useful for stratifying patients with distinct prognostic outcomes. Here, we looked for novel molecular signatures for triple negative breast cancers (TNBCs). By a bioinformatic approach, we identified a panel of genes, whose expression was positively correlated with disease-free survival in TNBC patients, namely IL18R1, CD53, TRIM, Jaw1, LTB, and PTPRCAP, showing specific immune expression profiles linked to survival prediction; most of these genes are indeed expressed in immune cells and are required for productive lymphocyte activation. According to our hypothesis, these genes were not, or poorly, expressed in different TNBC cell lines, derived from either primary breast tumours or metastatic pleural effusions. This conclusion was further supported in vivo, as immuno-histochemical analysis on biopsies of TNBC invasive ductal carcinomas highlighted differential expression of these six genes in cancer cells, as well as in intra- and peri-tumoral infiltrating lymphocytes. Our data open to the possibility that inter-tumour heterogeneity of immune markers might have predictive value; further investigations are recommended in order to establish the real power of cancer-related immune profiles as prognostic factors.
Interpreting the distributions of FRB observables
Creators: name: Connor, Liam
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Fast radio bursts (FRBs) are short-duration radio transients of unknown origin. Thus far, they have been blindly detected at millisecond timescales with dispersion measures (DMs) between 110--2600\,pc\,cm$^{-3}$. However, the observed pulse width, DM, and even brightness distributions depend strongly on the time and frequency resolution of the detection instrument. Spectral and temporal resolution also significantly affect FRB detection rates, similar to beam size and system-equivalent flux density (SEFD). I discuss the interplay between underlying FRB properties and instrumental response, and provide a generic formalism for calculating the \textit{observed} distributions of parameters given an intrinsic FRB distribution, focusing on pulse width and DM. I argue that if there exist many FRBs of duration $<
Baryon resonances from a novel fat-link fermion action
Creators: name: Melnitchouk, W.
name: Bilson-Thompson, S.
name: Bonnet, F. D. R.
name: Coddington, P. D.
name: Leinweber, D. B.
name: Williams, A. G.
name: Zanotti, J. M.
name: Zhang, J. B.
name: Lee, F. X.
Publisher: name: arXiv
Year: 2002
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We present first results for masses of positive and negative parity excited baryons in lattice QCD using an O(a^2) improved gluon action and a Fat Link Irrelevant Clover (FLIC) fermion action in which only the irrelevant operators are constructed with fat links. The results are in agreement with earlier calculations of N^* resonances using improved actions and exhibit a clear mass splitting between the nucleon and its chiral partner, even for the Wilson fermion action. The results also indicate a splitting between the lowest J^P = 1/2^- states for the two standard nucleon interpolating fields.
description: 5 pages, 3 figures, talk given by W.Melnitchouk at LHP 2001 workshop, Cairns, Australia
El método de Aula Invertida: Una visión histórica
Creators: name: Fidalgo-Blanco, Ángel
name: Sein-Echluce Lacleta, Marisa
name: García-Peñalvo, Francisco José
Publisher: name: Zenodo
Year: 2021
Subjects: Aula Invertida, Flip Teaching, Metodologías activas, MOOC

description: En este documento se analizará el método Aula Invertida desde el punto de vista de su desarrollo histórico para, de esta forma, dar a conocer los fundamentos a partir de los cuáles nació este método. Es importante destacar que el Aula Invertida nació en el contexto educativo; es decir, fue creado por el profesorado para ser utilizado con el alumnado. Por este motivo, este método está formado por un conjunto de procesos bien conocidos por el profesorado y que son, por tanto, fáciles de aplicar. A continuación se desarrollarán los siguientes puntos: 1. Para qué sirve. Describe la razón por la que se creó el método e identifica el problema que quiere resolver. 2. En qué consiste. Describe la forma en la que consigue resolver el problema identificado en el punto anterior. 3. Cuándo surge y cómo se desarrolló. Describe cuándo se popularizó el método y los distintos nombres que ha tenido, de los que algunos se conservan hasta la fecha actual. 4. El modelo original. Analiza el modelo de funcionamiento; esto es, el conjunto de procesos y la secuencia de los mismos.
Hadronic decays of B involving a tensor meson through a $b \to c$ transition
Creators: name: Kim, C. S.
name: Lee, Jong-Phil
name: Oh, Sechul
Publisher: name: arXiv
Year: 2002
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We re-analyze hadronic decays of B mesons to a pseudoscalar (P) and a tensor meson (T), or a vector meson (V) and a tensor meson, through a $b \to c$ transition. We discuss possible large uncertainties to branching ratios (BR's) of the relevant modes, mainly arising from uncertainties to the hadronic form factors for the $B \to T$ transition. The BR's and CP asymmetries for $B \to PT$ and VT decays are then calculated by using the form factors given in the ISGW2 model (the improved version of the original Isgur-Scora-Grinstein-Wise (ISGW) model). We find that the estimated BR's of many modes are increased by an order of magnitude, compared to the previous results calculated within the ISGW model.
description: 22 pages, LaTex; minor clarifications included; to appear in Phys. Rev. D
Dynamic spin-glass behavior in a disorder-free, two-component model of quantum frustrated magnets
Creators: name: Mila, Frederic
name: Dean, David
Publisher: name: arXiv
Year: 2001
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Motivated by the observation of a spin-glass transition in almost disorder-free Kagome antiferromagnets, and by the specific form of the effective low-energy model of the S=1/2, trimerized Kagome antiferromagnet, we investigate the possibility to obtain a spin-glass behavior in two-component, disorder-free models. We concentrate on a toy-model, a modified Ashkin-Teller model in a magnetic field that couples only to one species of spins, for which we prove that a dynamic spin-glass behavior occurs. The dynamics of the magnetization is closely related to that of the underlying Ising model in zero field in which spins and pseudo-spins are intimately coupled. The spin-glass like history dependence of the magnetization is a consequence of the ageing of the underlying Ising model.
description: 6 pages, LateX, 4 Figures; 1 Figure added, title, abstract and introduction modified, 2 references added. To appear in EPJB
Question Embeddings Based on Shannon Entropy: Solving intent classification task in goal-oriented dialogue system
Creators: name: Perevalov, Aleksandr
name: Kurushin, Daniil
name: Faizrakhmanov, Rustam
name: Khabibrakhmanova, Farida
Publisher: name: arXiv
Year: 2019
Subjects: subject: Computation and Language (cs.CL)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: Question-answering systems and voice assistants are becoming major part of client service departments of many organizations, helping them to reduce the labor costs of staff. In many such systems, there is always natural language understanding module that solves intent classification task. This task is complicated because of its case-dependency - every subject area has its own semantic kernel. The state of art approaches for intent classification are different machine learning and deep learning methods that use text vector representations as input. The basic vector representation models such as Bag of words and TF-IDF generate sparse matrixes, which are becoming very big as the amount of input data grows. Modern methods such as word2vec and FastText use neural networks to evaluate word embeddings with fixed dimension size. As we are developing a question-answering system for students and enrollees of the Perm National Research Polytechnic University, we have faced the problem of user's intent detection. The subject area of our system is very specific, that is why there is a lack of training data. This aspect makes intent classification task more challenging for using state of the art deep learning methods. In this paper, we propose an approach of the questions embeddings representation based on calculation of Shannon entropy.The goal of the approach is to produce low dimensional question vectors as neural approaches do and to outperform related methods, described above in condition of small dataset. We evaluate and compare our model with existing ones using logistic regression and dataset that contains questions asked by students and enrollees. The data is labeled into six classes. Experimental comparison of proposed approach and other models revealed that proposed model performed better in the given task.
description: Proceedings of International Conference on Applied Innovation in IT
STUDIES ON MEDICAL LABOR IN THE HEALTH AND ECONOMICS LITERATURE, PERIOD 2014 – 2018
Creators: name: Concha-Amin, Monica
name: Trindade, Carolina Sturm
name: Zen, Paulo Gazolla
name: Giergowicz, Bruna Bastos
Publisher: name: figshare
Year: 2021
Subjects: Economics

description: This article aims to identify which aspects of the Labor Market have been highlighted within the literature for the medical profession, which relate to the health care system of each country. The method used was an Integrative Review (IR), in which the five-year period from 2014 to 2018 was examined. With respect to the supply, the number of medical professionals was considered. A prominent aspect was personal job satisfaction, such as being close to family, working with colleagues in the same specialty and professional progression, to mention a few. A fundamental question for those who employ these professionals is how to deal with lack of availability when it is related to uneven or disproportionate distribution in certain locations. 
Synaptic control of DNA methylation involves activity-dependent degradation of DNMT3A1 in the nucleus
Creators: name: Bayraktar, Gonca
name: Yuanxiang, PingAn
name: Confettura, Alessandro D.
name: Gomes, Guilherme M.
name: Raza, Syed A.
name: Stork, Oliver
name: Tajima, Shoji
name: Suetake, Isao
name: Karpova, Anna
name: Yildirim, Ferah
name: Kreutz, Michael R.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Article
/631/378
/631/378/2584/1695
/13/1
/13/51
/13/106
/13/109
/13/95
/9/30
/14/19
/14/35
/14/63
/14
/96
/64/60
/82/80
article

description: Abstract: DNA methylation is a crucial epigenetic mark for activity-dependent gene expression in neurons. Very little is known about how synaptic signals impact promoter methylation in neuronal nuclei. In this study we show that protein levels of the principal de novo DNA-methyltransferase in neurons, DNMT3A1, are tightly controlled by activation of N-methyl-D-aspartate receptors (NMDAR) containing the GluN2A subunit. Interestingly, synaptic NMDARs drive degradation of the methyltransferase in a neddylation-dependent manner. Inhibition of neddylation, the conjugation of the small ubiquitin-like protein NEDD8 to lysine residues, interrupts degradation of DNMT3A1. This results in deficits in promoter methylation of activity-dependent genes, as well as synaptic plasticity and memory formation. In turn, the underlying molecular pathway is triggered by the induction of synaptic plasticity and in response to object location learning. Collectively, the data show that plasticity-relevant signals from GluN2A-containing NMDARs control activity-dependent DNA-methylation involved in memory formation.
Performance Analysis of a 5G Transceiver Implementation for Remote Areas Scenarios
Creators: name: Dias, Wheberth
name: Gaspar, Danilo
name: Mendes, Luciano
name: Chafii, Marwa
name: Matthé, Maximilian
name: Neuhaus, Peter
name: Fettweis, Gerhard
Publisher: name: arXiv
Year: 2019
Subjects: subject: Signal Processing (eess.SP)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: The fifth generation of mobile communication networks will support a large set of new services and applications. One important use case is the remote area coverage for broadband Internet access. This use case ha significant social and economic impact, since a considerable percentage of the global population living in low populated area does not have Internet access and the communication infrastructure in rural areas can be used to improve agribusiness productivity. The aim of this paper is to analyze the performance of a 5G for Remote Areas transceiver, implemented on field programmable gate array based hardware for real-time processing. This transceiver employs the latest digital communication techniques, such as generalized frequency division multiplexing waveform combined with 2 by 2 multiple-input multiple-output diversity scheme and polar channel coding. The performance of the prototype is evaluated regarding its out-of-band emissions and bit error rate under AWGN channel.
description: Presented in 2018 European Conference on Networks and Communications (EuCNC),18-21 June, 2018, Ljubljana, Slovenia
Synthesis, crystal structure, fluorescence and electrochemical properties of two Ag(I) complexes based on 2-(4′-pyridyl)-benzoxazole/SPPh3 ligands
Creators: name: Mao, Shanshan
name: Han, Xintong
name: Li, Chuang
name: Huang, Guozhen
name: Shen, Kesheng
name: Shi, Xinkui
name: Wu, Huilu
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified

description: To explore the luminescence properties of silver complexes in the solid state, two Ag(I) complexes, [Ag(4-PBO)2(NO3)] {di[2-(4′-pyridyl)-benzoxazole]silver(I) nitrate} (1) and [Ag2(SPPh3)4](ClO4)2 {[tetra(triphenylphosphine sulfide)disilver(I)] diperchlorate} (2) (4-PBO =2-(4′-pyridyl)-benzoxazole, SPPh3 = triphenylphosphine sulfide), have been synthesized and characterized by elemental analysis, FT-IR and UV-Vis spectroscopy. Single-crystal X-ray diffraction revealed that 1 is three-coordinate by two nitrogen atoms from two 4-PBO ligands and an oxygen atom from the coordinated nitrate anion forming a triangular plane configuration. In 2, the SPPh3 ligands adopt a monodentate coordinated and monoatomic bridging mode to connect two Ag(I) ions, resulting in a three-coordinate symmetrical binuclear structure. In the solid state, the luminescence properties of the ligands 4-PBO, SPPh3 and their complexes were investigated. The results demonstrated that 1 results in the fluorescence quenching of aggregates due to the strong π–π stacking effect. The fluorescence enhancement of 2 may be attributed to the “aggregation-induced emission” (AIE) effect of restricted intramolecular rotations of the peripheral phenyl rings against the central core. In addition, cyclic voltammograms of 1 and 2 indicated an irreversible Ag+/Ag couple.
Survey of energy-related occupant perceptions in a green-rated and in a non-rated building
Creators: name: Almeida, Laura M. M. C. E.
name: Tam, Vivian W. Y.
name: Le, Khoa N.
name: Huang, Zhiyu
name: Forbes, Samuel
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy

description: Surveys were delivered to the occupants of two university buildings in Sydney Australia to collect occupant perceptions related with energy use and the impact of the ‘green’ rating in occupant behaviour. Overall, 100 surveys were delivered in a 6-star building, rated according to the certification system Green Star, and in a non-rated building, from Western Sydney University. Occupants were inquired about their perception and interactions with heating, cooling, lighting, windows/doors opening, windows blinds and plug loads. This made possible to understand if there is a significant difference in energy-related occupant behaviour when comparing a green-rated to a non-green-rated building. Additionally, this study analysed if occupant’s gender, age and work role, as well as the characteristics of the built environment have impact on occupant behaviours and actions. It was possible to conclude that the ‘green’ rating has no impact in the way occupants interact with the buildings’ systems, and variables such as gender, age and the characteristics of the built environment have impact in the way occupants interact with the building features and systems. The results were obtained according to statistical analysis and intend to be a guideline for future research in the field of energy-related occupant behaviour.
Determining the Structure of Higgs Couplings at the LHC
Creators: name: Plehn, T.
name: Rainwater, D.
name: Zeppenfeld, D.
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Higgs boson production via weak boson fusion at the CERN Large Hadron Collider has the capability to determine the dominant CP nature of a Higgs boson, via the tensor structure of its coupling to weak bosons. This information is contained in the azimuthal angle distribution of the two outgoing forward tagging jets. The technique is independent of both the Higgs boson mass and the observed decay channel.
description: 5 pages, 4 figures, version accepted for publication in PRL
Radiosynthesis of [ 18 F]-Labelled Pro-Nucleotides (ProTides)
Creators: name: Cavaliere
name: Probst
name: Paisey
name: , Marshall
name: Dheere
name: Aigbirhio
name: McGuigan
name: Westwell
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: fluorination
ProTides
fluorine-18
radiolabelling
PET imaging

description: Phosphoramidate pro-nucleotides (ProTides) have revolutionized the field of anti-viral and anti-cancer nucleoside therapy, overcoming the major limitations of nucleoside therapies and achieving clinical and commercial success. Despite the translation of ProTide technology into the clinic, there remain unresolved in vivo pharmacokinetic and pharmacodynamic questions. Positron Emission Tomography (PET) imaging using [18F]-labelled model ProTides could directly address key mechanistic questions and predict response to ProTide therapy. Here we report the first radiochemical synthesis of [18F]ProTides as novel probes for PET imaging. As a proof of concept, two chemically distinct radiolabelled ProTides have been synthesized as models of 3′- and 2′-fluorinated ProTides following different radiosynthetic approaches. The 3′-[18F]FLT ProTide was obtained via a late stage [18F]fluorination in radiochemical yields (RCY) of 15−30% (n = 5, decay-corrected from end of bombardment (EoB)), with high radiochemical purities (97%) and molar activities of 56 GBq/μmol (total synthesis time of 130 min.). The 2′-[18F]FIAU ProTide was obtained via an early stage [18F]fluorination approach with an RCY of 1−5% (n = 7, decay-corrected from EoB), with high radiochemical purities (98%) and molar activities of 53 GBq/μmol (total synthesis time of 240 min).
Density Matrix Renormalization Group Approach to the Massive Schwinger Model
Creators: name: Byrnes, T.
name: Sriganesh, P.
name: Bursill, R. J.
name: Hamer, C. J.
Publisher: name: arXiv
Year: 2002
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: The massive Schwinger model is studied, using a density matrix renormalization group approach to the staggered lattice Hamiltonian version of the model. Lattice sizes up to 256 sites are calculated, and the estimates in the continuum limit are almost two orders of magnitude more accurate than previous calculations. Coleman's picture of `half-asymptotic' particles at background field (theta = pi) is confirmed. The predicted phase transition at finite fermion mass (m/g) is accurately located, and demonstrated to belong in the 2D Ising universality class.
description: 7 pages, 6 figures, submitted to PRL
The floatability of aerosols and waves damping on Titan's seas
Creators: name: Cordier, Daniel
name: Carrasco, Nathalie
Publisher: name: arXiv
Year: 2019
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Titan, Saturn's largest moon, has a dense atmosphere, together with lakes and seas of liquid hydrocarbons. These liquid bodies, which are in polar regions and up to several hundred kilometres in diameter, generally have smooth surfaces despite evidence of near-surface winds. Photochemically generated organic aerosols form a haze that can settle and potentially interact with the liquid surface. Here we investigate the floatability of these aerosols on Titan's seas and their potential to dampen waves. We find that the majority of aerosols are denser than the liquid hydrocarbons, but that some could have liquid-repelling properties. From calculation of the capillary forces, we propose that these 'liquidophobic' aerosols could float and form a persistent film on Titan's seas. We numerically model the wave damping efficiency of such a film under the conditions on Titan, demonstrating that even a film one molecule thick may inhibit formation of waves larger than a few centimetres in wavelength. We conclude that the presence of a floating film of aerosols deposited on Titan's lakes and seas could explain the remarkable smoothness of their surfaces.
description: Accepted in Nature Geoscience
Nonleptonic two-body charmless B decays involving a tensor meson in ISGW2 model
Creators: name: Kim, C. S.
name: Lee, Jong-Phil
name: Oh, Sechul
Publisher: name: arXiv
Year: 2002
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Nonleptonic charmless B decays into a pseudoscalar (P) or a vector (V) meson accompanying a tensor (T) meson are re-analyzed. We scrutinize the hadronic uncertainties and ambiguities of the form factors which appear in the literature. The Isgur-Scora-Grinstein-Wise updated model (ISGW2) is adopted to evaluate the relevant hadronic matrix elements. We calculate the branching ratios and CP asymmetries for various $B\to P(V)T$ decay processes. With the ISGW2 model, the branching ratios are enhanced by about an order of magnitude compared to the previous estimates. We show that the ratios $\calB(B\to VT)/\calB(B\to PT)$ for some strangeness-changing processes are very sensitive to the CKM angle $γ$ ($ϕ_3$).
description: 23 pages, REVTEX; minor clarifications included; to appear in Phys. Rev. D
RESENHA DO ARTIGO "LABORATÓRIO DE ESTRUTURA DA DISSERTAÇÃO TÉCNICA EM SALA DE AULA SOBRE VIOLÊNCIA NO CAMPO".
Creators: name: Moreira, Jhoanna D'Arc Araújo
name: De Alvarenga, Cleonice Felicia
Publisher: name: Zenodo
Year: 2018

description: Esta é uma resenha do artigo intitulado “Laboratório de estrutura da dissertação técnica em sala de aula sobre violência no campo”. Este artigo é de autoria de Jonas Rodrigo Gonçalves et al. O artigo aqui resenhado foi publicado no periódico “Revista JRG de Estudos Acadêmicos”, no Ano I, Vol. I, n.1, 2018.
Stacked Josephson junction SQUID
Creators: name: Krasnov, V. M.
Publisher: name: arXiv
Year: 2001
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Operation of a Superconducting Quantum Interference Device (SQUID) made of stacked Josephson junctions is analyzed numerically for a variety of junction parameters. Due to a magnetic coupling of junctions in the stack, such a SQUID has certain advantages as compared to an uncoupled multi-junction SQUID. Namely, metastability of current-flux modulation can be reduced and a voltage-flux modulation can be improved if junctions in the stack are phase-locked. Optimum operation of the SQUID is expected for moderately long, strongly coupled stacked Josephson junctions. A possibility of making a stacked Josephson junction SQUID based on intrinsic Josephson junctions in high-Tc superconductor is discussed.
description: 4 pages, 3 figures, presented at SQUID-2001 (Stenungsbaden September 2001)
Additional file 2: of The chromosome 11q13.3 amplification associated lymph node metastasis is driven by miR-548k through modulating tumor microenvironment
Creators: name: Zhang, Weimin
name: Hong, Ruoxi
name: Li, Lin
name: Wang, Yan
name: Du, Peina
name: Ou, Yunwei
name: Zhao, Zitong
name: Liu, Xuefeng
name: Xiao, Wenchang
name: Dong, Dezuo
name: Wu, Qingnan
name: Chen, Jie
name: Song, Yongmei
name: Zhan, Qimin
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: Supplementary Methods and Figures. (DOCX 3297 kb)
The Impact of Hypoxia on Neutrophil Degranulation and Consequences for the Host
Creators: name: Lodge
name: Cowburn
name: , Li
name: Condliffe
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: neutrophils
hypoxia
degranulation

description: Neutrophils are key effector cells of innate immunity, rapidly recruited to defend the host against invading pathogens. Neutrophils may kill pathogens intracellularly, following phagocytosis, or extracellularly, by degranulation and the release of neutrophil extracellular traps; all of these microbicidal strategies require the deployment of cytotoxic proteins and proteases, packaged during neutrophil development within cytoplasmic granules. Neutrophils operate in infected and inflamed tissues, which can be profoundly hypoxic. Neutrophilic infiltration of hypoxic tissues characterises a myriad of acute and chronic infectious and inflammatory diseases, and as well as potentially protecting the host from pathogens, neutrophil granule products have been implicated in causing collateral tissue damage in these scenarios. This review discusses the evidence for the enhanced secretion of destructive neutrophil granule contents observed in hypoxic environments and the potential mechanisms for this heightened granule exocytosis, highlighting implications for the host. Understanding the dichotomy of the beneficial and detrimental consequences of neutrophil degranulation in hypoxic environments is crucial to inform potential neutrophil-directed therapeutics in order to limit persistent, excessive, or inappropriate inflammation.