cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
DEVELOPMENT AND VALIDATION OF SUICIDAL IDEATION SCALE AMONG UNDERGRADUATE STUDENTS OF UNIVERSITY OF IBADAN, OYO STATE, NIGERIA
Creators: name: Adetokunbo Oluwatoyin Ikumoluyi
Publisher: name: Zenodo
Year: 2023
Subjects: suicidal ideation

description: A severe mental health problem that affects people of all ages and socioeconomic levels is suicidal ideation. Suicide is one of the major causes of mortality globally, with an estimated 800,000 people dying from it each year, according to the World Health Organization (WHO). The prevalence of suicide ideation among university students in Nigeria has grown to be a significant public health issue. In present times, the rate of suicide is alarmingly increasing due to various affecting factors. The stress and pressure of academic work, financial limitations, social isolation, and other circumstances, university students are particularly susceptible to mental health issues. In Nigeria, attempts to prevent suicide have mostly concentrated on addressing the risk factors connected to suicidal ideation, such as trauma, substance misuse, anxiety, and despair. The range of suicidal ideation varies from self-harm and unsuccessful attempts, which may be deliberately constructed to fail or be discovered, or may be fully intended to result in death. Suicidal ideation is “a form of mild suicidal behaviour, a predictor of suicidal behaviour, a clinical phenomenon in its own right” (Linden, Zaske & Ahrens 2003). Although most people who undergo suicidal ideation do not go on to make suicide attempts, a significant proportion do. Suicidal ideation is generally associated with depression; however, it seems to have associations with many other psychiatric disorders, life events, and family events, all of which may increase the risk of suicidal ideation.
The Laurent coefficients of the Hilbert series of a Gorenstein algebra
Creators: name: Herbig, Hans-Christian
name: Herden, Daniel
name: Seaton, Christopher
Publisher: name: arXiv
Year: 2016
Subjects: subject: Combinatorics (math.CO)
subject: Commutative Algebra (math.AC)
subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: Primary 05A15, Secondary 11B68, 13H10, 13A50

description: By a theorem of R. Stanley, a graded Cohen-Macaulay domain $A$ is Gorenstein if and only if its Hilbert series satisfies the functional equation \[ \operatorname{Hilb}_A(t^{-1})=(-1)^d t^{-a}\operatorname{Hilb}_A(t), \] where $d$ is the Krull dimension and $a$ is the a-invariant of $A$. We reformulate this functional equation in terms of an infinite system of linear constraints on the Laurent coefficients of $\operatorname{Hilb}_A(t)$ at $t=1$. The main idea consists of examining the graded algebra $\mathcal F=\bigoplus_{r\in \mathbb{Z}}\mathcal F_r$ of formal power series in the variable $x$ that fulfill the condition $φ(x/(x-1))=(1-x)^rφ(x)$. As a byproduct, we derive quadratic and cubic relations for the Bernoulli numbers. The cubic relations have a natural interpretation in terms of coefficients of the Euler polynomials. For the special case of degree $r=-(a+d)=0$, these results have been investigated previously by the authors and involved merely even Euler polynomials. A link to the work of H. W. Gould and L. Carlitz on power sums of symmetric number triangles is established.
description: 31 pages. From v1: Improved exposition, simplified proofs of Proposition 4.9 and Theorem 5.3, and corrected some errors. From v2: Changed the title to more clearly reflect the contents of the paper; replaced the example at the end of Section 2 with a more relevant example; minor corrections and updates
Nongovernmental organizations and the World Trade Organization
Creators: name: Van Liere, Adam Neal
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Since 1995 over 1,700 different NGOs have found ways to engage the WTO. They have submitted unsolicited amicus briefs and attended ministerial conferences en masse, disrupting the organization and aggravating its membership. They have also submitted over 460 position papers and participated in numerous WTO-sponsored symposia. In spite of these observations, very little is actually known about this overall group of NGOs: what causes do they represent and why do they do what they do? The state-centered emphasis of traditional international relations theory struggles to answer these questions. As an alternative, this dissertation seeks answers by profiling these NGOs and utilizing social movement theory in a multi-level framework to explore their motivations. Are these NGOs responding to the political opportunities at the WTO to defend critical interests, or are they merely using the WTO to help attract additional resources to their cause?
Engagement of Students with Intellectual and Developmental Disabilities in Postsecondary Education
Creators: name: Furgang, Emily
Publisher: name: University of North Carolina at Chapel Hill
Year: 2013

description: This dissertation presents finding s from an ethnographic study of students with intellectual and developmental disabilities (IDD) enrolled in a specialized postsecondary education program at a public university in North Carolina. Specifically, it discusses how 10 students engaged in postsecondary education activities and developed student identities over the course of one academic year. A transactional perspective is used to frame this study holistically, such that the transactions of various factors contributing to the students' occupation and identity development are considered. This research is significant for occupational science because it examines a period of transition that is influential in shaping current and future life occupations. Moreover, it explores the novel occupational experiences of a population that has historically been restricted from engaging in postsecondary education. This study utilized qualitative methods, including semi-structured interviews and participant observation with college students with IDD. Findings address the transactional nature of engagement in postsecondary education and the construction of the students' occupations and identities, while affirming the dialectical relationship of occupation and identity previously described in the occupational science literature. These findings are portrayed through stories of the students' experiences. Further areas for research related to the experiences of college students with IDD engaging in postsecondary education are also discussed.
Mediation of the effects of obesity on coronary heart disease in a bi-ethnic cohort: the Atherosclerosis Risk in Communities (ARIC) Study
Creators: name: McClain, Jill E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Excess adiposity is associated with physiologic risk factors for coronary heart disease (CHD), including dyslipidemia, high blood pressure and insulin resistance, however few studies have analyzed mediation of the obesity-CHD relationship by individual physiologic risk factors. Mediation can be examined using structural equation modeling (SEM), which has several advantages over standard regression for analyses of mediation, including significance-testing of the individual indirect (mediated) effects. We used data from the Atherosclerosis Risk in Communities (ARIC) Study, a longitudinal cohort of 15,792 African American and White adults aged 45-64 years at baseline (1987-1989) and followed through 2005, to examine mediation of the effects of body mass index (BMI) on CHD hazard. Physiologic risk factors examined included total and high density lipoprotein (HDL) cholesterol, triglycerides, systolic and diastolic blood pressure (SBP, DBP) and insulin resistance. The overall effect of BMI on CHD was curved, with a steeper slope at lower compared to higher BMI levels. Mediated effects of BMI on CHD tended to be strongest through HDL cholesterol and insulin resistance. Mediation was more moderate through total cholesterol and SBP, and was null through DBP and triglycerides. In models that included all 6 hypothesized mediators, BMI was not directly associated with CHD. We found no differences in mediation by race or gender. Because antihypertensive medication use is highly prevalent in this cohort (31% at baseline), we explored the impact of medication use on our analyses involving blood pressure. The associations of BMI with blood pressure and with CHD were markedly attenuated in participants taking antihypertensive medication compared to participants not taking antihypertensive medications, though the association of blood pressure with CHD was not different between the two groups. When associations of BMI with SBP and DBP were compared in the same individuals before and after initiating treatment with antihypertensive medications, no differences were found. Overall, these results highlight the complexity of analyses of blood pressure in persons being treated with antihypertensive medication and underscore the importance of traditional physiologic risk factors, particularly HDL cholesterol and insulin resistance, as mediators of the effect of obesity on CHD.
MACBETH: management of avatar conflict by employment of a technique hybrid
Creators: name: Burns, Eric M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Since virtual objects do not prevent users from penetrating them, a virtual environment user may place his real hand inside a virtual object. If the virtual environment system prevents the user's hand avatar from penetrating the object, the hand avatar must be placed somewhere other than the user's real hand position. I propose a technique, named MACBETH (Management of Avatar Conflict By Employment of a Technique Hybrid) for managing the position of a user's hand avatar in a natural manner after it has been separated from the user's real hand due to collision with a virtual object. This technique balances visual/proprioceptive discrepancy in position and velocity by choosing each so that they are equally detectable. To gather the necessary information to implement MACBETH, I performed user studies to determine users' detection thresholds for visual/proprioceptive discrepancy in hand position and velocity. I then ran a user study to evaluate MACBETH against two other techniques for managing the hand avatar position: the rubber-band and incremental-motion techniques. Users rated MACBETH as more natural than the other techniques and preferred MACBETH over both. Users performed better on a hand navigation task with MACBETH than with the incremental-motion technique and performed equally well as with the rubber-band technique.
The Use of Nitrous Oxide for Routine Dental Treatment in Pediatric Patients with Sickle Cell Anemia
Creators: name: Grady-Williams, Diamond
Publisher: name: University of Illinois at Chicago
Year: 2023

description: Purpose To identify differences in mean oxygenation levels between healthy pediatric patients and pediatric patients with sickle cell disease (SCD) receiving nitrous oxide (N2O) for dental procedures and to determine if N2O decreases oxygen saturation levels for SCD patients. Methods Patients aged 2-17 years with SCD and healthy age matched controls were recruited at their preventive or restorative visits from 2019-2023. N2O up to 50% oxygen and 50% nitrous was administered during routine restorative treatment. Oxygen saturation was measured via a pulse oximeter before starting nitrous, at 10-minute intervals throughout treatment, and after nitrous oxide termination. Statistical analysis was completed using SPSS. Results There was a significant difference in average O2 saturation at baseline between cases and controls; however, there was no significant difference at 10 mins, 20 mins, or 30 mins. There was no significant difference in O2 saturation between cases and controls after terminating N2O. Conclusion Use of N2O for dental treatment up to 50% nitrous/50% oxygen mixture is safe in SCD patients. The oxygen saturation of healthy patients and patients with SCD increases with the use of N2O. In addition, N2O use in patients with SCD can alleviate anxiety and increase the pain threshold, decreasing the risk for vaso-occlusive crisis.
On Haar systems for groupoids
Creators: name: Deitmar, Anton
Publisher: name: arXiv
Year: 2016
Subjects: subject: Operator Algebras (math.OA)
subject: FOS: Mathematics

description: It is shown that a locally compact groupoid with open range map does not always admit a Haar system. It then is shown how to construct a Haar system if the stability groupoid and the quotient by the stability groupoid both admit one.
Effect of olive leaf (Olea europaea L.) extract addition to broiler diets on the growth performance, breast meat quality, antioxidant capacity and caecal bacterial populations
Creators: name: Xie, Pujun
name: Deng, Yejun
name: Huang, Lixin
name: Zhang, Caihong
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: This study aims to evaluate the effect of olive leaf extract (OLE) on growth performance, breast meat quality, antioxidant capacity and caecal microbiota regulation. OLE containing 51.5% oleuropein, 25.6% polyphenols and 6.2% flavonoids, was designed to different supplement levels ranging from 0.1% OLE (OLE0.1) to 0.5% OLE (OLE0.5) into a basal diet, separately. The whole feeding period lasts for 35 days after 7-day hatching from the egg. 720 1-day-age healthy Arbour Acres male broilers were thus divided into five experimental groups and one control group, consist of 20 broilers per group for six parallel experiments in triplicate. The results showed that the levels of average daily feed intake (ADFI) and average daily weight gain (ADG) of the broilers were decreased (p < 0.05) after the addition of 0.3% OLE. Moreover, the breast meat shear force was decreased by 34.4% (p < 0.05). The glutathione (GSH) levels in the meat were increased by 76.64% (p < 0.05); the levels of total superoxide dismutase (T-SOD) and glutathione peroxidase (GSH-Px) were increased by 50.4% and 120%, respectively. And the malondialdehyde (MDA) levels in the meat were reduced by 34.2% (p < 0.05). Additionally, a decreased intensity of Escherichia coli (p < 0.05) and an increased intensity of Lactobacillus and Bifidobacterium (p < 0.05) were observed. Overall, supplementing 0.3% OLE into daily diet enables enhancing breast meat antioxidation, amplifying the abundance of Lactobacillus and Bifidobacterium as well as diminishing the abundance of E. coli in the caecum.HIGHLIGHTSOLE contains 51.5% oleuropein, 25.6% of TP and 6.2% TF levels.OLE addition at 0.3% lowers shear force and raises the GSH’s level of the meat.OLE causes a decrease in E. coli and an increase in Lactobacillus and Bifidobacterium. OLE contains 51.5% oleuropein, 25.6% of TP and 6.2% TF levels. OLE addition at 0.3% lowers shear force and raises the GSH’s level of the meat. OLE causes a decrease in E. coli and an increase in Lactobacillus and Bifidobacterium.
Remote Control of Neuronal Signaling in vivo
Creators: name: Rogan, Sarah
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: A significant challenge for neuroscientists is to determine how both electrical and chemical signals affect the activity of cells and circuits and how the nervous system subsequently translates that activity into behavior. Remote, bidirectional manipulation of those signals with high spatiotemporal precision is an ideal approach to addressing that challenge. Recently, neuroscientists have developed a diverse set of tools that permit such experimental manipulation with varying degrees of spatial, temporal, and directional control. These tools use light, peptides, and small molecules to primarily activate ion channels and G protein-coupled receptors (GPCRs) that in turn activate or inhibit neuronal firing. By monitoring the electrophysiological, biochemical, and behavioral effects of such activation/inhibition, researchers can better understand the links between brain activity and behavior. The research in this thesis centers on using a class of designer GPCRs, termed Designer Receptors Exclusively Activated by Designer Drugs (DREADDs), to remotely and non-invasively control the activity of particular neuronal populations. DREADDs are evolved muscarinic receptors that selectively respond to the otherwise inert compound clozapine-N-oxide (CNO) and not to their native ligand, acetylcholine. Using a chemical-genetic approach, I demonstrate that the Gq-coupled DREADD (hM3Dq), which is derived from the human muscarinic M3 receptor, can be used to activate neuronal firing selectively in the cortex and hippocampus of mice expressing hM3Dq. The neuronal activation subsequently results in behavioral and electrophysiological changes. Then, I use those behavioral changes as a readout to examine the underlying neurocircuitry and discuss the findings in the context of psychosis. The tools for remote control of neuronal activity, including DREADDs, differ in the direction of their effect (activation/inhibition, hyperpolarization/depolarization), their onset and offset kinetics (milliseconds/minutes/hours), the degree of spatial resolution they afford, and their invasiveness. While none of these tools is perfect, they each have advantages and disadvantages, which I describe, and they are all still works-in-progress. I conclude with a discussion of the clinical and translational applications of these technologies and provide suggestions for improving upon the existing tools.
The Lindeberg theorem for Gibbs-Markov dynamics
Creators: name: Denker, Manfred
name: Senti, Samuel
name: Zhang, Xuan
Publisher: name: arXiv
Year: 2016
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 37A50, 60F05

description: A dynamical array consists of a family of functions $\{f_{n,i}: 1\le i\le k(n), n\ge 1\}$ and a family of initial times $\{τ_{n,i}: 1\le i\le k(n), n\ge 1\}$. For a dynamical system $(X,T)$ we identify distributional limits for sums of the form $$ S_n= \frac 1{s_n}\sum_{i=1}^{k(n)} [f_{n,i}\circ T^{τ_{n,i}}-a_{n,i}]\qquad n\ge 1$$ for suitable (non-random) constants $s_n>0$ and $a_{n,i}\in \mathbb R$, where the functions $f_{n,i}$ are locally Lipschitz continuous. Although our results hold for more general dynamics, we restrict to Gibbs-Markov dynamical systems for convenience. In particular, we derive a Lindeberg-type central limit theorem for dynamical arrays. Applications include new central limit theorems for functions which are not locally Lipschitz continuous and central limit theorems for statistical functions of time series obtained from Gibbs-Markov systems.
description: 25 pages
Human choices, slope and vegetation productivity determine patterns of traditional alpine summer grazing
Creators: name: Raniolo, Salvatore
name: Sturaro, Enrico
name: Ramanzin, Maurizio
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Neuroscience
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Grazing behaviour influences animal productivity and the conservation of grassland ecosystem services. We used GPS tracking and remote sensing (NDVI index) to monitor the grazing patterns of lactating cows on the ‘Malga Ombretta’ summer farm (1,957 m asl) in the Dolomites, eastern Italian Alps, from 5th July to 5th August 2018. The pasture area (35 ha) was grazed by a mixed herd of Simmental and Alpine grey cows (stocking density = 0.6 LU/ha) under traditional management: each morning the farmer led the cows to graze in a selected sub-area of pasture, and during the afternoon he left them free to graze unrestricted until they returned to the barn for the night. GPS positions were collected every minute from 9 Simmental and 4 Alpine Grey cows with low milk production during the time they were outdoors. The farmer’s choice of where to drive the herd to graze in the morning determined the distances the cows walked/day, which varied from 2.0 to 8.9 km, and favoured the use of higher and steeper areas that the cows tended otherwise to avoid. When free in the afternoon, the cows selected areas with higher NDVI values than those selected by the farmer in the morning, and Alpine Grey cows used slightly higher slopes and altitudes than Simmental cows, suggesting better adaptation to mountain pastures. The study revealed highly heterogenous grazing patterns dependent on multiple factors that can be assessed at fine temporal and spatial scales using GPS and remote sensing technologies to improve grazing management.HIGHLIGHTSDaily distances walked and grazing patterns were influenced differently by the farmer’s decisions and the animals’ choices in response to environmental features.The NDVI index of vegetation productivity suggested that cows grazed more productive areas when free than when driven by the farmer.GPS tracking and remote sensing shed light on how human and animal choices regarding grazing are influenced by environmental features. Daily distances walked and grazing patterns were influenced differently by the farmer’s decisions and the animals’ choices in response to environmental features. The NDVI index of vegetation productivity suggested that cows grazed more productive areas when free than when driven by the farmer. GPS tracking and remote sensing shed light on how human and animal choices regarding grazing are influenced by environmental features.
Network-based gut microbiome analysis in dogs
Creators: name: Scarsella, Elisa
name: Jha, Aashish
name: Sandri, Misa
name: Stefanon, Bruno
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: A growing number of studies in the last decade described the microbial populations in different niches of the organism thank to High-throughput DNA sequencing techniques, that are easily accessible to researchers. Furthermore, network analysis allows characterisation of bacteria that are indirectly linked to outcomes such as disease, diet and host sex through their association with other taxa. The present work on the gut microbiome follows previous research in which data were collected from 8 in-house dietary intervention studies in healthy dogs. Animals were divided according to diet and sex. The process of sample collection, storage, DNA extraction and sequencing, bioinformatic and statistical analysis followed a tailored, internally defined pipeline. The extracted DNA was prepared for sequencing of the V3 and V4 regions of the 16 rRNA gene. Correlation network analysis was performed by calculating pairwise relationships between taxa using the Sparse Correlations for Compositional Data (SparCC) algorithm. First, we identified candidate bacteria that were highly abundant in the microbial community, and second, we examined taxa that were directly related to diet and sex factors. In summary, this study underpins the network structure of the gut microbiome of dogs categorised by diet and sex and provides a better explanation for the interactions between bacteria that led to the grouping of dogs based on environmental or genetic factors. Specifically, this study has provided the basis for understanding how the bacterial community in the gut is interconnected and functions as a function of diet composition and sex.HighlightsNetwork analysis could allow indirect association between bacteria composing the gut microbiome and outcomes, such as disease, diet and sex of the host.This research put the basis on the definition of enterotypes also in dogs, a concept already applied in humans.Positively correlated bacteria, belonging to modules could help to modulate diets and therapies for the treatment of enteropathies or gut-related pathologies linked to a dysbiosis status of the host. Network analysis could allow indirect association between bacteria composing the gut microbiome and outcomes, such as disease, diet and sex of the host. This research put the basis on the definition of enterotypes also in dogs, a concept already applied in humans. Positively correlated bacteria, belonging to modules could help to modulate diets and therapies for the treatment of enteropathies or gut-related pathologies linked to a dysbiosis status of the host.
A Learning Algorithm for Change Impact Prediction
Creators: name: Musco, Vincenzo
name: Carette, Antonin
name: Monperrus, Martin
name: Preux, Philippe
Publisher: name: arXiv
Year: 2015
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: Change impact analysis consists in predicting the impact of a code change in a software application. In this paper, we take a learning perspective on change impact analysis and consider the problem formulated as follows. The artifacts that are considered are methods of object-oriented software, the change under study is a change in the code of the method, the impact is the test methods that fail because of the change that has been performed. We propose an algorithm, called LCIP that learns from past impacts to predict future impacts. To evaluate our system, we consider 7 Java software applications totaling 214,000+ lines of code. We simulate 17574 changes and their actual impact through code mutations, as done in mutation testing. We find that LCIP can predict the impact with a precision of 69%, a recall of 79%, corresponding to a F-Score of 55%.
description: 5th International Workshop on Realizing Artificial Intelligence Synergies in Software Engineering, 2016
In Vivo Discoveries in MDM2-Mediated p53 Regulation
Creators: name: Tackmann, Nicole
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: The transcription factor p53 is a stress sensor and tumor suppressor. Its many target genes contribute to tumor suppression through regulation of cell cycle arrest, senescence, apoptosis, and metabolism. Ubiquitously transcribed and translated, p53 regulation is primarily mediated through mouse double minute 2 (MDM2). MDM2 binds to p53, inhibits its transcriptional activation capabilities, and harbors E3 ubiquitin ligase activity to facilitate p53 degradation. Upon cellular stress, upstream signaling transducers modify or bind MDM2 to prevent its inhibition of p53. Ribosomal proteins (RPs) bind to MDM2 either in the response to ribosomal biogenesis stress or oncogenic overproduction of RPs, which occurs in cancer due to increased proliferation. p19ARF also transduces hyperproliferative signals, inhibiting MDM2 to stabilize p53. Both p19ARF- and RP-MDM2 binding are important for p53 activation following oncogenic c-MYC overexpression, but whether these interactions are interdependent was unknown. We utilized mice bearing the MDM2C305F mutation, which disrupts RPL11- and RPL5-MDM2 binding, crossed them with mice containing deletion of p19ARF, and examined c-MYC-induced tumorigenesis. We found that concomitant disruption of these signals enhanced tumorigenesis, indicating that RP-MDM2 and p19ARF-MDM2 binding are two distinct mechanisms causing c-MYC-induced p53 activation. Further, we examined whether RP-MDM2 interaction could transduce proliferative signals in cancers driven by other oncogenes. We crossed MDM2C305F mice to mice bearing an HrasG12V transgene or an ApcMin allele, which promote melanoma and colorectal tumor formation, respectively. We found that in response to RAS stimulation, RPL11 and RPL5 do not participate in MDM2 inhibition. In response to APC deletion, RPL11 and RPL5 expression and MDM2 binding are increased in a colon-specific manner. As a result, MDM2C305F mice experience increased colorectal tumorigenesis and decreased p53 activation. Collectively, these results suggest that RP-MDM2 interaction is important for transducing individual oncogenic stress signals in a p19ARF-independent manner. We have also examined the role of MDM2 E3 ligase activity in controlling p53 following the overexpression of c-MYC. Using mice bearing the MDM2Y487A mutation, which disrupts MDM2 E3 ligase activity, we found that MDM2 E3 ligase activity is dispensable for regulating p53 following oncogenic c-MYC overexpression and surprisingly that its disruption may provide a survival advantage.
Optimization of Energy-Constrained Wireless Powered Communication Networks with Heterogeneous Nodes
Creators: name: Abd-Elmagid, Mohamed A.
name: ElBatt, Tamer
name: Seddik, Karim G.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: In this paper, we study wireless networks where nodes have two energy sources, namely a battery and radio frequency (RF) energy harvesting circuitry. We formulate two optimization problems with different objective functions, namely maximizing the sum throughput and maximizing the minimum throughput, for enhanced fairness. Furthermore, we show the generality of the proposed system model through characterizing the conditions under which the two formulated optimization problems can be reduced to the corresponding problems of different known wireless networks, namely, conventional wireless networks (battery-powered) and wireless powered communications networks (WPCNs) with only RF energy harvesting nodes. In addition, we introduce WPCNs with two types of nodes, with and without RF energy harvesting capability, in which the nodes without RF energy harvesting are utilized to enhance the sum throughput, even beyond WPCNs with all energy harvesting nodes. We establish the convexity of all formulated problems which opens room for efficient solution using standard techniques. Our numerical results show that the two types of wireless networks, namely WPCNs with only RF energy harvesting nodes and conventional wireless networks, are considered, respectively, as lower and upper bounds on the performance of the generalized problem setting in terms of the maximum sum throughput and the maxmin throughput. Moreover, the results reveal new insights and throughput-fairness trade-offs unique to our new problem setting.
description: Accepted for publication in Wireless Networks, 2017
Effects of HIIT training and HIIT combined with circuit resistance training on measures of physical fitness, miRNA expression, and metabolic risk factors in overweight/obese middle-aged women
Creators: name: ZOUHAL, Hassane
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Sports Sciences
subject: Medicine and Health Sciences

description: Objective: MicroRNAs are short non-coding RNA molecules that regulate biological processes such as metabolic risk factors. The purpose of this study was to examine the effects of 10 weeks of high-intensity interval training (HIIT) and HIIT combined with circuit resistance (HCRT) on selected measures of physical fitness, the expression of miR-9, -15a, -34a, -145, and -155 as well as metabolic risk factors including lipid profiles and insulin resistance in middle-aged overweight/obese women.
MEDIATION DURING INTERNATIONAL CONFLICTS: EVIDENCE FROM SUMNER WELLES’ MISSION TO EUROPE IN 1940
Creators: name: Baily, Spencer
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The important question that this study attempted to answer is Do diplomatic trips that neutral countries take during wartime influence the conflict? In investigating this question, a trip to Europe taken by U.S. Under Secretary Sumner Welles was inspected. A yardstick was created from the findings of prior literature on mediation. Welles’ trip during the beginning of World War II was then compared to this yardstick. The author found that Welles’ mission was insightful but did not influence European countries. Finally, diplomatic trips taken during wartime do affect the conflict but only if certain tasks are performed by the mediator.
The application of Legendre Polynomials to model muscularity and body condition score in primiparous Italian Simmental cattle
Creators: name: Buonaiuto, Giovanni
name: Lopez-Villalobos, Nicolas
name: Niero, Giovanni
name: Degano, Lorenzo
name: Dadati, Enrico
name: Formigoni, Andrea
name: Visentin, Giulio
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: The aim of the present study was to develop a model to predict muscularity and body condition score (BCS) during the lactation of Italian Simmental dairy cows in Emilia Romagna herds. A total of 2656 Italian Simmental primiparous cows from 324 dairy herds were linear classified between 2002 and 2020. Lactation curves for muscularity and BCS were modelled for each cow using random regression model. The model included the fixed effects of age at linear scoring and days in milk modelled with a Legendre polynomial, and the random effects of herd-year of classification, cow and days in milk for each cow modelled with Legendre polynomials. The most parsimonious model included a fixed cubic Legendre polynomial and a random linear polynomial for cow effects. Results indicated that, on an average, BCS nadir was anticipated to that of muscularity, and, in both cases, this moment was around the lactation peak, when animals have the greatest nutrients requirement. After this period, both BCS and muscularity recovered up to post-partum levels. Moreover, after the 9 month of lactation, the absolute growth rate of muscularity and BCS was negative, suggesting that late-gestating cows could potentially enter a phase of body conformation loss. Results reported in the current research indicate that random regression using Legendre polynomials can be successfully employed to predict muscularity and BCS during the lactation of dairy cows.HighlightsModelling dairy cows’ muscularity and BCS allows to use these parameters as indicator traits for functionality in dairy cows.The use of prediction model of muscularity and BCS allows to understand the evolution of these conformation traits during the lactation.The analysis of muscularity and BCS allows to assess health and welfare status of dairy cows, which is essential to maximise production performances. Modelling dairy cows’ muscularity and BCS allows to use these parameters as indicator traits for functionality in dairy cows. The use of prediction model of muscularity and BCS allows to understand the evolution of these conformation traits during the lactation. The analysis of muscularity and BCS allows to assess health and welfare status of dairy cows, which is essential to maximise production performances.
Influence of increasing levels of oregano essential oil on intestinal morphology, intestinal flora and performance of Sewa sheep
Creators: name: Sun, Jiale
name: Cheng, Zhipeng
name: Zhao, Yanling
name: Wang, Yaomei
name: Wang, Honghui
name: Ren, Zili
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Science Policy
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: The purpose of this experiment was to study the effects of oregano essential oil (OEO) on the performance, intestinal morphology and intestinal flora of fattening Sewa sheep. Sixty 20-month-old Sewa sheep with similar body weights (BWs) and in good health were randomly divided into four groups. The groups were fed a diet containing 0 mg/kg OEO (group A), 150 mg/kg (group B), 300 mg/kg (group C) or 450 mg/kg (group D). Daily gain, slaughter rate and other production performance parameters were analysed in the test sheep (mean ± standard error). Intestinal morphology was analysed by tissue sectioning, and intestinal flora was analysed by 16S rRNA genome sequencing. The indexes, including average daily gain (ADG), slaughter rate, villus length of the small intestine and number of beneficial bacteria in the intestinal flora, in group C were significantly higher than those in the other groups. Supplementation with 300 mg/kg OEO concentrate in the diets can improve the growth performance of Sewa sheep by changing their intestinal morphology and modifying their intestinal flora structure. Conclusively, these encourage to further verifying in practice positive evidence in improving growth performance of OEO supplementation in the diets for Sewa sheep.HighlightsOregano essential oil (OEO) can improve the performance of Sewa sheep by changing the intestinal morphology and regulating the intestinal flora structure. Oregano essential oil (OEO) can improve the performance of Sewa sheep by changing the intestinal morphology and regulating the intestinal flora structure.
The Role of Curcumin in Modulating Colonic Microbiota During Colitis and Colon Cancer Prevention
Creators: name: McFadden, Rita-Marie
Publisher: name: University of North Carolina at Chapel Hill Graduate School
Year: 2014
Subjects: subject: Immunology
subject: FOS: Clinical medicine
subject: Dentistry
subject: Microbiology
subject: FOS: Biological sciences

description: Background: Inflammatory bowel diseases (IBD) are a major risk factor for colon cancer. Intestinal microbiota have been identified as the target of inflammation that affects the progression of colitis-associated colorectal cancer (CAC). With diet being a key determinant of the gut microbial ecology, dietary interventions are an attractive avenue for the prevention of CAC. Curcumin is the most active constituent of the ground rhizome of the Curcuma Longa plant, which has been demonstrated to have anti-inflammatory, anti-oxidative, pro-apoptotic and anti-proliferative properties. However, the exact role of curcumin in colon cancer prevention and modulation of the microbial communities are yet to be determined. Methods: A mouse model of CAC was utilized in which Il10-/- mice on 129/SvEv background develop progressive colitis. On the starting day, WT or Il10-/- mice received a 100µL i.p. injection of 10mg/kg body weight of azoxymethane (AOM) or sterile saline (continued once a week for six weeks total) and were started on one of the following curcumin-supplemented diets: 0%, 0.05%, 0.1% or 0.5%. Mice were monitored for weight loss, rectal prolapse, rectal bleeding, and stool consistency. Stools were collected every four weeks for microbial analysis (Illumina 16S rRNA profiling). At the conclusion of the study, mice were assessed for tumor burden, colonic histopathology and colonic cytokine profile. Results: Curcumin-supplemented diets increased survival, decreased colon weight/length ratios and reduced tumor burden in a dose-dependent manner. Distal colon histopathology in Il10-/- mice exposed to AOM with the 0.5% curcumin diet demonstrated a reduction of inflammation score and a reduction in the frequency of adenocarcinoma detection. Curcumin altered the microbial ecology in the gut of Il10-/- mice fed the 0.5% curcumin diet. DIfferences in microbial diversity were observed in mice with tumors vs. without, as well as in mice that had spontaneous vs. AOM-induced tumors. Conclusions: In a dose-dependent manner, dietary curcumin results in a less severe presentation of colitis, in a reduced risk of progression to CRC upon exposure to AOM and a more diverse colonic microbial ecology in the Il10-/- mice. This suggests that curcumin functions as an effective agent for restoring healthy gut homeostasis.
MPEC 2023-O52 : 2023 OA1
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 OA1

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Writing poems on trees: genre and metapoetics in Vergil's Eclogues and Georgics
Creators: name: Henkel, John H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: This dissertation seeks to provide firmer grounding for the study of metapoetics in Roman poetry by investigating Vergil's use of metapoetic narrative, symbolism, and metaphor in the Eclogues and Georgics. I argue that Vergil's patterning of characters in the Eclogues after existing narratives, his discussion of farming in the Georgics, and the related references to trees and shade in the Eclogues, can be read as reflecting metaphorically on the theory and practice of poetry in Rome in the late first century BCE. By comparing Vergil's discussions of trees and farming with passages of explicit literary criticism in Horace, Cicero, and others, I show that Vergil structures the Eclogues and Georgics in a way that allows references to agriculture and the natural world to be read as metaphors not only for life, as some Georgics scholars have shown, but also for poetry. My first chapter demonstrates my method by discussing a specific, pointed allusion to Aratus and his Hellenistic reception in Vergil's passage on the farmer's nighttime activities (Geo. 1.291-296). Here, as throughout the dissertation, I argue that certain passages about trees and/or farming can also be seen as literal reflections of the terms of literary-critical metaphors, such as the wakefulness (agrypnie) for which Callimachus praises Aratus's Phaenomena (Callimachus Epigram 27). My second, third, and fourth chapters discuss a coherent pattern of literary symbolism in Vergil's references to trees, forests, shade, and grafting in the Eclogues (Ch. 2-3) and the Georgics (Ch. 4). In Chapters 2-3 I also argue that Vergil patterns the narratives of Eclogues 2, 8, and 10 after erotic narratives from Callimachus, Theocritus, and Gallus in order to represent the interaction between Gallan love elegy and Theocritean pastoral in the Eclogues through the love affairs of characters in these poems. In my conclusion I outline further patterns of metapoetic symbolism in Vergil and show that other Augustan poets both allude to Vergil's metapoetic symbols and, using the same technique, devise metapoetic symbols of their own.
A software framework for data based analysis
Creators: name: Krätzig, Markus
Publisher: name: Humboldt-Universität zu Berlin, Wirtschaftswissenschaftliche Fakultät
Year: 2005
Subjects: subject: Zeitreihenanalyse
subject: Wissenschaftliches Rechnen
subject: Software Entwicklung
subject: JMulTi
subject: time series analysis
subject: scientific computing
subject: software engineering
subject: 330 Wirtschaft
subject: 17 Wirtschaft
subject: QH 237

description: Es wird das Software Framework JStatCom vorgestellt, welches die Enwicklung von leistungsfähigen grafischen Benutzerschnittstellen für Daten-basierte Analysemethoden wesentlich vereinfacht, wobei der Schwerpunkt auf Methoden der Ökonometrie, insbesondere der Zeitreihenanalyse liegt. Das Konzept besteht darin, sämtliche wiederkehrenden Aufgaben mit Hilfe von Java-Klassen zu lösen, sowie die Ausführung von speziellen Algorithmen an externe Programme, wie z.B. Gauss oder Matlab, zu delegieren. Auf diese Weise können schon existierende Prozeduren aus verschiedenen Programmiersprachen wiederverwendet werden. Weiterhin wird die ökonometrische Anwendungssoftware JMulTi beschrieben, die auf Basis dieses Frameworks erstellt wurde.
description: This work presents the software framework JStatCom which is geared towards the development of powerful graphical user interfaces for data based analysis methods, especially for econometrics and time series analysis. The concept is to solve all recurring tasks with the help of Java classes and to delegate the execution of special algorithms to external programs, for example Gauss or Matlab. This way it is possible to reuse already existing procedures written in different programming languages. Furthermore, the econometric software JMulTi will be presented which has been developed with the help of this framework.
Individual Risk Aversion Through the Life Cycle
Creators: name: Parada Contzen, Marcela
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: This dissertation studies the evolution of individual risk aversion through the life cycle using observed measures of individual risk aversion coming from survey responses. I develop a dynamic model of individual lifetime behavior and jointly estimate a set of correlated dynamic equations for observed risk aversion, wealth-related decisions (employment, occupation, investment, and savings), and other characteristics that an individual may value independently of wealth (family and health). I consider how to incorporate observed measures of individual risk aversion into a dynamic empirical model of individual behavior and how to reconcile the use of these observed measures with the economic theory of individual behavior over time. In an empirical model that allows risk preferences (calculated from survey responses) to be an endogenous determinant of observed behaviors, I find that there is correlation, through unobserved characteristics between risk aversion and wealth-related behaviors, as well as causal effect of risk preferences on these outcomes. The joint estimation of observed risk aversion and behaviors reduces the bias on the estimated marginal effects of endogenous variables that impact wealth-related decisions and better approximate the distribution of individual unobserved heterogeneity. The estimated model is used to analyze investment policies associated with wealth accumulation in the Chilean private retirement system. In this system, each dependent worker must have an individual account where every period the worker contributes ten percent of her income for accumulating retirement wealth. I evaluate alternative time-varying default investment schemes showing that, over seven years, slightly riskier investment strategies may increase individual asset accumulation by eight percent or more. Increases in mandatory contribution rates by three and five percent generate statistically significant increases in asset accumulation of 10 and 16 percent, respectively. Finally, when simulating women with children who are currently not employed to hold a part-time job, wealth accumulation increases by 10 percent over a seven year time frame.