cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Inverse design and AI/Deep generative networks in food design: A comprehensive review
Creators: name: Alsarayreh, Mahmoud
name: Reis, Mariza
name: Carr, Alistair
name: Reis, Marlon Martins dos
Publisher: name: AgResearch
Year: 2023
Subjects: Food sciences

description: Background Food material science has evolved to support the development of food products by connecting food structure, sensory, nutrition, food processing, and digestion with impact in consumers. However, food design has not evolved to deal with this increased complexity of food systems. And the ability to understand, capture the attention, and transform consumer demands into the chemical and physical attributes of the final product remains one of the biggest challenges in the food industry. As a result, new ways to support food design are necessary. Scope and approach This review describes the state-of-the-art of applications in food design utilizing artificial intelligence (AI)/Deep Generative Networks, including available resources and emerging capabilities and its relationship with the concept of inverse design. Key findings and conclusions Food design and formulation involve complex processes and many design parameters need to be considered while developing data-driven approaches. Most approaches identified are based on the association among ingredients, but less focus has been given to functional properties. Representation of data remains a real challenge and a very important research gap toward achieving a real and applicable concept of digital food design. Overall methods based on deep learning and natural language processing are the most utilized. Deep generative-based approaches have been rarely described and remain a critical research area. NZBIDA
On Densities of the Product, Quotient and Power of Independent Subordinators
Creators: name: Kataria, K. K.
name: Vellaisamy, P.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60E07

description: We obtain the closed form expressions for the densities of the product, quotient, power and scalar multiple of independent stable subordinators. Similar results for the independent inverse stable subordinators are discussed. This is achieved by expressing the densities of stable and inverse stable subordinators in terms of the Fox's $H$-function.
Ciência Aberta nas humanidades: critérios para determinação e ordenação de autoria
Creators: name: Souza, Lidia Costa de
name: Príncipe, Eloisa
Publisher: name: Zenodo
Year: 2023

description: Apresentação realizada na sessão "Pecha Kucha I" da 14ª Conferência Lusófona de Ciência Aberta, Natal Brasil, de 18 a 21 de setembro de 2023.
The use of lead for simulating the hot rolling of steel :
Creators: name: Wong, Sook Fun.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
In silico screening of Pueraria tuberosa (PTY-2) for targeting COVID-19 by countering dual targets Mpro and TMPRSS2
Creators: name: Shree, Priya
name: Mishra, Priyanka
name: Kumar, Prateek
name: Pandey, Harsh
name: Giri, Rajanish
name: Chaube, Radha
name: Garg, Neha
name: Tripathi, Yamini Bhusan
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 60506 Virology

description: COVID-19 pandemic was started in Wuhan city of China in December 2019; immensely affected global population. Herein, an effort was made to identify potential inhibitors from active phytochemicals of Pueraria tuberosa (PTY-2) via molecular docking study. Our study showed five potential inhibitors (Robinin, Genistin, Daidzin, Hydroxytuberosone, Tuberostan) against Mpro and five inhibitors (Robinin, Anhydrotuberosin, Daidzin, Hydroxytuberosone, Stigmasterol) against TMPRSS2. Out of these, Robinin, Daidzin and Hydroxytuberosone were common inhibitors for Mpro and TMPRSS2. Among these, Robinin showed the highest binding affinity, therefore, tested for MD simulation runs and found stable. ADMET analysis revealed the best-docked compounds are safe and follow the Lipinski Rule of Five. Thus, it could be suggested that phytochemicals of PTY-2 could serve as potential inhibitors for COVID-19 targets. Communicated by Ramaswamy H. Sarma Application of active phytoconstituents of Pueraria tuberosa (PTY-2) for the repurposing in the management of COVID-19. Promising effect of Robinin as a multifocal inhibitor of virus-host interaction including main protease (Mpro) and TMPRSS2 with highest binding energy through molecular docking and molecular dynamics simulations studies. Robinin acts as common inhibitor against Mpro and TMPRSS2.
Determination of optimal capacity shares for Eppalock Reservoir using stochastic dynamic programming
Creators: name: Haydon, Shane Robert.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Synthesis of photochromic oxygen-containing yttrium hydride
Creators: name: Montero, J.
name: Martinsen, F. A.
name: Lelis, M.
name: Karazhanov, S. Zh.
name: Hauback, B. C.
name: Marstein, E. S.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Photochromic oxygen-containing yttrium hydride has been synthesized using a two step process. The process consists of an initial sputter deposition of oxygen-free yttrium hydride YH$_\mathrm{x}$, followed by a controlled reaction with air that causes incorporation of oxygen into the material. An in-situ study of the YH$_\mathrm{x}$ as it reacted with oxygen was made possible by applying an aluminium capping layer with a low but non-zero oxygen permeability prior to air exposure. During the reaction, the visual appearance of the YH$_\mathrm{x}$ went from dark and opaque to transparent and yellowish. This transition was accredited incorporation of oxygen into the material, as shown through analysis with energy dispersive x-ray spectroscopy (EDS) and x-ray photoemission spectroscopy (XPS). Grazing incidence x-ray diffraction (GIXRD) studies revealed an fcc structure both before and after oxygen exposure, with a lattice parameter that increased from 5.2 Å to 5.4 Å during the reaction. With the lattice parameter in the oxygen free YH$_\mathrm{x}$ being equal to that reported earlier for YH$_\mathrm{2}$, our findings suggest that the non-reacted YH$_\mathrm{x}$ in this study is in-fact YH$_\mathrm{2}$.
Beyond the Standard Model in Vector Boson Scattering Signatures
Creators: name: Bachas, Dinos
name: Barak, Liron
name: Bishara, Fady
name: Brivio, Ilaria
name: Buarque Franzosi, Diogo
name: Cacciapaglia, Giacomo
name: Fassi, Farida
name: Kasimi, Eirini
name: Kirschenmann, Henning
name: Petridou, Chara
name: Prosper, Harrison
name: Romao, Jorge C.
name: Rosell, Ignasi
name: Salvioni, Ennio
name: Santos, Rui
name: Slawinska, Magdalena
name: Strong, Giles Chatham
name: Szleper, Michał
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2020
Subjects: review
vector boson: scattering
electroweak interaction: symmetry breaking
experimental results
new physics
signature
effective field theory
CERN LHC Coll
sensitivity
network

description: The high-energy scattering of massive electroweak bosons, known as vector boson scattering (VBS), is a sensitive probe of new physics. VBS signatures will be thoroughly and systematically investigated at the LHC with the large data samples available and those that will be collected in the near future. Searches for deviations from Standard Model (SM) expectations in VBS facilitate tests of the Electroweak Symmetry Breaking (EWSB) mechanism. Current state-of-the-art tools and theory developments, together with the latest experimental results, and the studies foreseen for the near future are summarized. A review of the existing Beyond the SM (BSM) models that could be tested with such studies as well as data analysis strategies to understand the interplay between models and the effective field theory paradigm for interpreting experimental results are discussed. This document is a summary of the EU COST network 'VBScan' workshop on the sensitivity of VBS processes for BSM frameworks that took place December 4-5, 2019 at the LIP facilities in Lisbon, Portugal. In this manuscript we outline the scope of the workshop, summarize the different contributions from theory and experiment, and discuss the relevant findings.
Hyperspectral imaging through vacuum packaging for monitoring cheese biochemical transformation caused by Clostridium metabolism
Creators: name: Reis, Marlon Martins dos
name: Dixit, Yash
name: Carr, Alistair
name: Tu, Christine
name: Palevich, Faith
name: Gupta, Tanu
name: Reis, Mariza
Publisher: name: AgResearch
Year: 2023
Subjects: Food sciences

description: This study developed a novel method for monitoring cheese contamination with Clostridium spores non-invasively using hyperspectral imaging (HSI). The ability of HSI to quantify Clostridium metabolites was investigated with control cheese and cheese manufactured with milk contaminated with Clostridium tyrobutyricum, Clostridium butyricum and Clostridium sporogenes. Microbial count, HSI and SPME-GC-MS data were obtained over 10 weeks of storage. The developed method using HSI successfully quantified butyric acid (R2 = 0.91, RPD = 3.38) a major compound of Clostridium metabolism in cheese. This study creates a new venue to monitor the spatial and temporal development of late blowing defect (LBD) in cheese using fast and non-invasive measurement. NZBIDA
The Landscape of Quantum Sensing
Creators: name: Prabhu, Sridhar
name: Wright, Logan G.
name: Onodera, Tatsuhiro
name: McMahon, Peter L.
Publisher: name: Zenodo
Year: 2023
Subjects: quantum sensing
quantum information

description: We are researchers without any background in quantum sensing who are thinking of entering the field and who wanted to understand the landscape of schemes and concepts that exist already. The PDF enclosed in this repository is an attempt at categorizing the very broad range of quantum-sensing methods. We welcome comments and suggestions! In particular, we would love to hear about: *1. What did we miss?* Are there any techniques that are important for researchers new to quantum sensing to know about that we omitted? *2. What did we get wrong?* Did we misunderstand or miscategorize any methods or papers? Even if were were not formally _wrong_, how could we have done better in characterizing the methods we included?
Antiproliferative activity on Trypanosoma cruzi (Y strain) of the triterpene 3β,6β,16β-trihidroxilup-20 (29)-ene isolated from Combretum leprosum
Creators: name: de Araújo, José Ismael F.
name: Aires, Natália L.
name: Almeida-Neto, Francisco W. Q.
name: Marinho, Márcia M.
name: Marinho, Emanuelle M.
name: Magalhães, Emanuel Paula
name: de Menezes, Ramon R. P. P. B.
name: Sampaio, Tiago L.
name: Martins, Alice Maria Costa
name: Teixeira, Edson H.
name: Dotto, Ana Rafaela Freitas
name: Amaral, Wanderlei do
name: Teixeira, Alexandre Magno R.
name: de Lima-Neto, Pedro
name: Marinho, Emmanuel S.
name: Santos, Hélcio S. dos
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Chagas disease infects approximately seven million people worldwide. Benznidazole is effective only in the acute phase of the disease, with an average cure rate of 80% between acute and recent cases. Therefore, there is an urgent need to find new bioactive substances that can be effective against parasites without causing so many complications to the host. In this study, the triterpene 3β-6β-16β-trihydroxilup-20 (29)-ene (CLF-1) was isolated from Combretum leprosum, and its molecular structure was determined by NMR and infrared spectroscopy. The CLF-1 was also evaluated in vitro and in silico as potential trypanocidal agent against epimastigote and trypomastigote forms of Trypanosoma cruzi (Y strain). The CLF-1 demonstrated good results highlighted by lower IC50 (76.0 ± 8.72 µM, 75.1 ± 11.0 µM, and 70.3 ± 45.4 µM) for epimastigotes at 24, 48 and 72 h, and LC50 (71.6 ± 11.6 µM) for trypomastigotes forms. The molecular docking study shows that the CLF-1 was able to interact with important TcGAPDH residues, suggesting that this natural compound may preferentially exert its effect by compromising the glycolytic pathway in T. cruzi. The ADMET study together with the MTT results indicated that the CLF-1 is well-absorbed in the intestine and has low toxicity. Thus, this work adds new evidence that CLF-1 can potentially be used as a candidate for the development of new options for the treatment of Chagas disease. Communicated by Ramaswamy H. Sarma
A high fraction of Be stars in young massive clusters: evidence for a large population of near-critically rotating stars
Creators: name: Bastian, N.
name: Cabrera-Ziri, I.
name: Niederhofer, F.
name: de Mink, S.
name: Georgy, C.
name: Baade, D.
name: Correnti, M.
name: Usher, C.
name: Romaniello, M.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Recent photometric analysis of the colour-magnitude diagrams (CMDs) of young massive clusters (YMCs) have found evidence for splitting in the main sequence and extended main sequence turn-offs, both of which have been suggested to be caused by stellar rotation. Comparison of the observed main sequence splitting with models has led various authors to suggest a rather extreme stellar rotation distribution, with a minority ($10-30$\%) of stars with low rotational velocities and the remainder ($70-90$\%) of stars rotating near the critical rotation (i.e., near break-up). We test this hypothesis by searching for Be stars within two YMCs in the LMC (NGC 1850 and NGC 1856), which are thought to be critically rotating stars with decretion disks that are (partially) ionised by their host stars. In both clusters we detect large populations of Be stars at the main sequence turn-off ($\sim30-60$\% of stars), which supports previous suggestions of large populations of rapidly rotating stars within massive clusters.
description: 6 pages, 3 figures, accepted for publication in MNRAS
The Hubble Space Telescope UV Legacy Survey of Galactic Globular Clusters -- XI. The horizontal branch in NGC\,6388 and NGC\,6441
Creators: name: Tailo, M.
name: D'Antona, F.
name: Milone, A. P.
name: Bellini, A.
name: Ventura, P.
name: Di Criscienzo, M.
name: Cassisi, S.
name: Piotto, G.
name: Salaris, M.
name: Brown, T. M.
name: Vesperini, E.
name: Bedin, L. R.
name: Marino, A. F.
name: Nardiello, D.
name: Anderson, J.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The Hubble Space Telescope UV Legacy survey of Galactic Globular Clusters (GC) is characterising many different aspects of their multiple stellar populations. The "Grundahl-jump" (G-jump) is a discontinuity in ultraviolet brightness of blue horizontal branch (HB) stars, signalling the onset of radiative metal levitation. The HB Legacy data confirmed that the G-jump is located at the same T$_{eff}$ ($\simeq$11,500 K) in nearly all clusters. The only exceptions are the metal-rich clusters NGC 6388 and NGC 6441, where the G-jump occurs at T$_{eff}\simeq$13-14,000K. We compute synthetic HB models based on new evolutionary tracks including the effect of helium diffusion, and approximately accounting for the effect of metal levitation in a stable atmosphere. Our models show that the G-jump location depends on the interplay between the timescale of diffusion and the timescale of the evolution in the T$_{eff}$ range 11,500 K$\lessapprox$T$_{eff}\lessapprox$14,000 K. The G-jump becomes hotter than 11,500 K only for stars that have, in this T$_{eff}$ range, a helium mass fraction Y>0.35. Similarly high Y values are also consistent with the modelling of the HB in NGC 6388 and NGC 6441. In these clusters we predict that a significant fraction of HB stars show helium in their spectra above 11,500 K, and full helium settling should only be found beyond the hotter G-jump.
description: 12 pages, 9 figures
Arjunetin as a promising drug candidate against SARS-CoV-2: molecular dynamics simulation studies
Creators: name: Arumugam, Gandarvakottai Senthilkumar
name: Sen, Asmita
name: Dash, Swati S.
name: Mitra, Kartik
name: Doble, Mukesh
name: Rajaraman, Gopalan
name: Gummadi, Sathyanarayana N.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Stem and bark of the tree Terminalia arjuna Wight & Arn. (Combretaceae) has been documented to exhibit therapeutic properties like cardiotonic, anticancer, antiviral, antibacterial, antifungal, hypercholesterolemia, hypolipidemic, and anti-coagulant. Our previous studies have shown that, ethanolic extract of T. arjuna bark exhibits radical scavenging anti-oxidant activity and also effectively inhibited catalase activity. In this study, oleanane triterpenoids type compounds viz., oleanolic acid, arjunolic acid, arjunolitin, arjunetin were isolated from ethanolic bark extract as bio-active compound and their structures were elucidated using 1H, 13C NMR, HR-ESIMS, IR. Of the various compounds, Arjunetin showed significant inhibition of catalase activity as compared to the other compounds. Based on the structural similarity between arjunetin and current antiviral drugs, we propose that arjunetin might exhibit antiviral activity. Molecular docking and molecular dynamics studies showed that arjunetin binds to the binds to key targets of SARS-CoV-2 namely, 3CLpro, PLpro, and RdRp) with a higher binding energy values (3CLpro, −8.4 kcal/mol; PLpro, −7.6 kcal/mol and RdRp, −8.1 kcal/mol) as compared with FDA approved protease inhibitor drugs to Lopinavir (3CLpro, −7.2 kcal/mole and PLpro −7.7 kcal/mole) and Remdesivir (RdRp −7.6 kcal/mole). To further investigate this, we performed 200–500 ns molecular dynamics simulation studies. The results transpired that the binding affinity of Arjunetin is higher than Remdesivir in the RNA binding cavity of RdRp. Based on structural similarity between arjunetin and Saikosaponin (a known antiviral agents) and based on our molecular docking and molecular dynamic simulation studies, we propose that arjunetin can be a promising drug candidate against Covid-19. Communicated by Ramaswamy H. Sarma
A dislocation-based explanation of quasi-elastic release in shock-loaded aluminum
Creators: name: Yao, Song-Lin
name: Pei, Xiao-Yang
name: Yu, Ji-Dong
name: Bai, Jing-Song
name: Wu, Qiang
Publisher: name: arXiv
Year: 2016
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: A novel explanation of the quasielastic release phenomenon in shock compressed aluminum is presented. A dislocation-based model, taking into account dislocation substructures and evolution, is applied to simulate the elastic plastic response of both single crystal and poly crystalline aluminum. The calculated results are in good agreement with experimental results from not only the velocity profiles but also the shear strength and dislocation density, which demonstrates the accuracy of our simulations. Simulated results indicate that dislocation immobilization during dynamic deformation results in a smooth increase of yield stress, which leads to the quasi-elastic release, while the generation of dislocations caused by the plastic release wave results in the appearance of a transition point between the quasielastic release and the plastic release in the profile.
description: 13 pages and 12 figures
Aluminium plain bearings alloy design for fatigue resistance
Creators: name: Peterson, R. C. .
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Integridade acadêmica no contexto da Ciência Aberta: cenário brasileiro de questões éticas e legais em pesquisas científicas
Creators: name: Rezende, Laura Vilela Rodrigues
name: Stueber, Ketlen
name: Monteiro, Elizabete Cristina de Souza de Aguiar
name: Silva, Fabiano Couto Corrêa da
name: Oliveira, Alexandre Faria de
name: Alves, Romulo Arantes
Publisher: name: Zenodo
Year: 2023

description: Apresentação realizada na sessão "Pecha Kucha I" da 14ª Conferência Lusófona de Ciência Aberta, Natal Brasil, de 18 a 21 de setembro de 2023.
Profit, productivity, and eco-efficiency of using Caucasian clover/ grass pastures in hill country farms
Creators: name: Stevens, David
name: Taylor, Anna
Publisher: name: AgResearch
Year: 2023
Subjects: Agricultural, veterinary and food sciences

description: The following study was conducted to establish whether significant amounts of Caucasian clover-based pastures in hill country farms can increase eco-efficiency and profitability. Published data were used to predict the production of Caucasian clover-based pastures, based on weather data and soil moisture deficit prediction, for four sheep and beef farms with low rainfall in the South Island. Scenarios with 10, 20 or 30% of the flat and rolling areas improved with Caucasian clover/grass pastures were compared to current systems based on resident white clover-based pastures. A staged approach, to utilise the extra high-quality feed produced, used a sequentially process to improve productivity by increasing lamb finishing, higher hogget liveweight, better ewe nutrition or more beef finishing, depending on initial efficiency metrics. Time to maximum production using an annual establishment programme of 5% of the target areas in Caucasian clover/grass mixtures took 4 to 6.5 years (10% and 30% respectively). Adding Caucasian clover/grass increased pasture production by 5.5% while product/kg DM consumed increased by 12.8% and profitability by 22% when either sheep or beef production were used to capture the extra amount and quality of pasture. Greenhouse gas (GHG) emissions were increased by only 6.3%, resulting in more efficient meat production.
The role of beam waist in Laguerre-Gauss expansion of vortex beam
Creators: name: Vallone, Giuseppe
Publisher: name: arXiv
Year: 2016
Subjects: subject: Optics (physics.optics)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Laguerre-Gauss (LG) modes represent an orthonormal basis set of solutions of the paraxial wave equation. LG are characterized by two integer parameters $n$ and $\ell$ that are related to the radial and azimuthal profile of the beam. The physical dimension of the mode is instead determined by the beam waist parameter $w_0$: only LG modes with the same $w_0$ satisfy the orthogonality relation. Here, we derive the scalar product between two LG modes with different beam waists and show how this result can be exploited to derive different expansions of a generic beam in terms of LG modes. In particular, we apply our results to the recently introduced Circular Beams, by deriving a previously unknown expansion. We finally show how the waist parameter must be chosen in order to optimize such expansion.
description: 5 pages
MPEC 2023-Q04 : 2016 SM3
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
In silico and in vitro investigation of anticancer effect of newly synthesized nonivamide-s-allyl cysteine ester
Creators: name: Vijayan, Sudha
name: Loganathan, Chitra
name: Sakayanathan, Penislusshiyan
name: Thayumanavan, Palvannan
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Nonivamide (NOV), less pungent analogue of capsaicin present in various Capsicum species is known for various biological properties. S-allyl cysteine (SAC) abundantly present in aged garlic extract is gaining importance for anticancer property. NOV was esterified with SAC to increase the biological activity. In silico ADME analysis revealed the drug-likeness of NOV-SAC. Molecular docking and dynamics simulation analysis were done to understand the interaction of NOV-SAC with therapeutic target proteins (human estrogen receptor α, tumo protein negative regulator mouse double minute 2, B-cell lymphoma 2 and cyclin-dependent kinase 2) to treat cancer. NOV-SAC interacted with these proteins stably with favorable binding energy which was calculated through MMGBSA method. In line with in silico results, NOV-SAC showed antiproliferative activity against breast cancer cell line (MCF-7). NOV-SAC treatment increased ROS generation, decreased the antioxidant level, arrested cells at G1/S phase, disrupted mitochondrial membrane potential and initiated DNA fragmentation. The expression of p53 is increased by NOV-SAC treatment, in concordance the ratio of Bcl-2/Bax was decreased. Altogether, NOV-SAC was synthesized for the first time and it induced apoptosis in MCF-7 cells through triggering ROS generation and increasing the expression of p53. The in silico results has been mirrored in in vitro analysis of NOV-SAC against cancer cell line. Communicated by Ramaswamy H. Sarma
Appropriate Assessment Criteria to the Prototype Area for Quality of Life According to the New Theory, Applied to the "Khok Nong Na Model"
Creators: name: Hanphakdeeniyom, Anitta
Publisher: name: Faculty of Management Science Nakhon Pathom Rajabhat University.
Year: 2023
Subjects: assessment criteria
Khok Nong Na model
sub-district learning center

description: Journal of Management Science Nakhon Pathom Rajabhat University, 10, 1, 76-91
The Causal Relationship Model Between Quality of Working Life and Organizational Culture the affect Organizational Commitment of Supporting Staffs of Rajamangala University of Technology Krungthep
Creators: name: Sakchai Jantasang
Publisher: name: Faculty of Management Science Nakhon Pathom Rajabhat University.
Year: 2023
Subjects: Quality of Working Life
Organizational Culture
Organizational Commitment

description: Journal of Management Science Nakhon Pathom Rajabhat University, 10, 1, 92-106
Remote ionospheric structure by inversion of ground backscatter ionograms
Creators: name: Ong, C. Y. .
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
VNF Placement with Replication for Load Balancing in NFV Networks
Creators: name: Carpio, Francisco
name: Dhahri, Samia
name: Jukan, Admela
Publisher: name: arXiv
Year: 2016
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Network Function Virtualization (NFV) is a new paradigm, enabling service innovation through virtualization of traditional network functions located flexibly in the network in form of Virtual Network Functions (VNFs). Since VNFs can only be placed onto servers located in networked data centers, which is the NFV's salient feature, the traffic directed to these data center areas has significant impact on network load balancing. Network load balancing can be even more critical for an ordered sequence of VNFs, also known as Service Function Chains (SFCs), a common cloud and network service approach today. To balance the network load, VNF's can be placed in a smaller cluster of servers in the network thus minimizing the distance to the data center. The optimization of the placement of these clusters is a challenge as also other factors need to be considered, such as the resource utilization. To address this issue, we study the problem of VNF placement with replications, and especially the potential of VNFs replications to help load balance the network. We design and compare three optimization methods, including Linear Programing (LP) model, Genetic Algorithm (GA) and Random Fit Placement Algorithm (RFPA) for the allocation and replication of VNFs. Our results show that the optimum placement and replication can significantly improve load balancing, for which we also propose a GA heuristics applicable to larger networks.
description: Submitted to IEEE International Conference on Communications 2017
Flavan-based phytoconstituents inhibit Mpro, a SARS-COV-2 molecular target, in silico
Creators: name: Mukherjee, Soham
name: Sharma, Deepika
name: Sharma, Ajay Kumar
name: Jaiswal, Shreya
name: Sharma, Nancy
name: Borah, Sangkha
name: Kaur, Gurjot
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: A well-validated in-silico approach can provide promising drug candidates for the treatment of the ongoing CoVID19 pandemic. In this study, we have screened 32 phytochemical constituents (PCCs) with Mpro binding site (PDB:6W63) based on which we identified three possible candidates that are likely to be effective against CoVID19—viz., licoleafol (binding energy: −8.1 kcal/mol), epicatechin gallate (–8.5 kcal/mol) and silibinin (–8.4 kcal/mol) that result in higher binding affinity than the known inhibitor, X77 (–7.7 kcal/mol). Molecular dynamics (MD) simulations of PCCs-Mpro complex confirmed molecular docking results with high structural and dynamical stability. The selected compounds were found to exhibit low mean squared displacements (licoleafol: 2.25 ± 0.43 Å, epicatechin gallate: 1.93 ± 0.35 Å, and silibinin: 1.39 ± 0.19 Å) and overall low fluctuations of the binding complexes (root mean squared fluctuations below 2 Å). Visualization of the MD trajectories and structural analyses revealed that they remain confined to the initial binding region, with mean fluctuations lower than 3 Å. To access the collective motion of the atoms, we performed principal component analysis demonstrating that the first 10 principal components are the major contributors (approximate contribution of 80%) and are responsible for the overall PCCs motion. Considering that the three selected PCCs share the same flavan backbone and exhibit antiviral activity against hepatitis C, we opine that licoleafol, epi-catechin gallate, and silibinin can be promising anti-CoVID19 drug candidates. Communicated by Ramaswamy H. Sarma
Revista Bindi: cultura, democracia e direito - Número 02/2023
Creators: name: Willians Meneses
Publisher: name: Zenodo
Year: 2023
Subjects: Cultura; Democracia; Direito

description: A Revista Bindi é uma publicação acadêmica cuja missão é fomentar a produção e a difusão do conhecimento sobre a obra e pensamento do filósofo Norberto Bobbio, bem como sobre os assuntos concernentes às suas linhas de pesquisa: cultura, democracia e direito. Apesar de não ser editada por uma instituição universitária, a revista Bindi utiliza os mais rigorosos critérios e boas práticas em editoração científica para garantir a qualidade de seu conteúdo. Neste sentido, os artigos enviados para publicação passam necessariamente pela revisão por pares no sistema double blind peer review e em estrita observação dos padrões internacionais de integridade ética e editorial.
Telecommuting in the COVID 19 Pandemic Situation in Thai Public Organizations
Creators: name: Kanyaphatr Panhomya
Publisher: name: Faculty of Management Science Nakhon Pathom Rajabhat University.
Year: 2023
Subjects: Telecommuting
the readiness of organizational change
the COVID 19 Pandemic Situation

description: Journal of Management Science Nakhon Pathom Rajabhat University, 10, 1, 123-134
A cosmographic analysis of the transition to acceleration using SN-Ia and BAO
Creators: name: Muthukrishna, Daniel
name: Parkinson, David
Publisher: name: arXiv
Year: 2016
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We explore the distance-redshift relation using a cosmographic methodology, and show how the cosmographic parameters can be used to determine the redshift of transition from deceleration to acceleration. Such a transition at a low redshift occupies only a small region of the available parameter space, and the prior assumption of an early period of deceleration can significantly change the posterior constraints. We use available type Ia Supernovae (SN-Ia) and Baryon Acoustic Oscillation (BAO) data sets to determine the cosmographic deceleration $q_0$, jerk $j_0$, snap $s_0$ and lerk $l_0$ parameters. The parameters are consistent with the $Λ$CDM model for a flat universe within 2-sigma. We derive constraints on the redshift of transition from deceleration to acceleration for the different expansions, and find $z_{\rm acc} > 0.14$ at 95% confidence in the most conservative case.
description: 21 pages, 10 figures, 4 tables
As competências para a Ciência Aberta de jovens investigadores em ciência da informação de Brasil e Portugal
Creators: name: Santos, Elis
name: Borges, Maria Manuel
name: Veiga, Viviane
Publisher: name: Zenodo
Year: 2023

description: Apresentação realizada na sessão "Pecha Kucha I" da 14ª Conferência Lusófona de Ciência Aberta, Natal Brasil, de 18 a 21 de setembro de 2023.
The accuracy of biochemical interactions is ensured by endothermic stepwise kinetics
Creators: name: Michel, Denis
name: Boutin, Benjamin
name: Ruelle, Philippe
Publisher: name: arXiv
Year: 2016
Subjects: subject: Molecular Networks (q-bio.MN)
subject: FOS: Biological sciences

description: The discerning behavior of living systems relies on accurate interactions selected from the lot of molecular collisions occurring in the cell. To ensure the reliability of interactions, binding partners are classically envisioned as finely preadapted molecules, evolutionarily selected on the basis of their affinity in one-step associations. But the counterselection of inappropriate interactions can in fact be much more efficiently obtained through difficult multi-step adjustment, whose final high energy state is locked by a fluctuation ratchet. The progressive addition of molecular bonds during stereo-adjustment can be modeled as a predominantly backward random walk whose first arrival is frozen by a micro-irreversible transition. A new criterion of ligand specificity is presented, that is based on the ratio rejection/incorporation. In addition to its role in the selectivity of interactions, this generic recipe can underlie other important biological phenomena such as the regular synthesis at low level of supramolecular complexes, monostable kinetic bimodality, substrate concentration thresholds or the preparation of rapidly depolymerizable structureswith stored energy, like microtubules.
description: 14 pages, 8 figures
Discrete nonlinear dynamic modelling of power system loads
Creators: name: Chiong, S. C. .
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Large Halloween Asteroid at Lunar Distance
Creators: name: Müller, T. G.
name: Marciniak, A.
name: Butkiewicz-Bąk, M.
name: Duffard, R.
name: Oszkiewicz, D.
name: Käufl, H. U.
name: Szakáts, R.
name: Santana-Ros, T.
name: Kiss, C.
name: Santos-Sanz, P.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The near-Earth asteroid (NEA) 2015 TB145 had a very close encounter with Earth at 1.3 lunar distances on October 31, 2015. We obtained 3-band mid-infrared observations with the ESO VLT-VISIR instrument and visual lightcurves during the close-encounter phase. The NEA has a (most likely) rotation period of 2.939 +/- 0.005 hours and the visual lightcurve shows a peak-to-peak amplitude of approximately 0.12+/-0.02 mag. We estimate a V-R colour of 0.56+/-0.05 mag from MPC database entries. Applying different phase relations to the available R-/V-band observations produced H_R = 18.6 mag (standard H-G calculations) or H_R = 19.2 mag & H_V = 19.8 mag (via the H-G12 procedure), with large uncertainties of approximately 1 mag. We performed a detailed thermophysical model analysis by using spherical and ellipsoidal shape models. The thermal properties are best explained by an equator-on (+/- ~30 deg) viewing geometry during our measurements with a thermal inertia in the range 250-700 Jm-2s-0.5K-1 (retrograde rotation) or above 500 Jm-2s-0.5K-1 (prograde rotation). We find that the NEA has a minimum size of 625 m, a maximum size of just below 700 m, and a slightly elongated shape with a/b ~1.1. The best match to all thermal measurements is found for: (i) Thermal inertia of 900 Jm-2s-0.5K-1; D_eff = 644 m, p_V = 5.5% (prograde rotation); regolith grain sizes of ~50-100 mm; (ii) thermal inertia of 400 Jm-2s-0.5K-1; D_eff = 667 m, p_V = 5.1% (retrograde rotation); regolith grain sizes of ~10-20 mm. A near-Earth asteroid model (NEATM) confirms an object size well above 600 m, significantly larger than early estimates based on radar measurements. We give recommendations for improved observing strategies for similar events in the future.
description: Accepted for publication in Astronomy & Astrophysics, 11 pages, 9 figures
In-silico evidence of ADAM metalloproteinase pathology in cancer signaling networks
Creators: name: Sen, Plaboni
name: Kandasamy, Thirukumaran
name: Ghosh, Siddhartha Sankar
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Lack of effective targeted therapies often contributes to poor clinical outcomes of aggressive malignancies associated with drug resistance, angiogenesis and metastasis. Literature mining portrays the major role of ADAM17 in cancer and inflammatory diseases. However, it is quite challenging to design a candidate drug for targeting ADAM17 due to its structural similarity with the catalytic domain of the matrix metalloproteases (MMPs). The present study reports the protein-protein interaction analysis of ADAM17, along with the molecular docking and MD simulation studies for the screened compounds. Our analysis confirms the association of ADAM17 with numerous oncogenes that facilitates cancer progression and inflammation, especially the members of the Notch, receptor tyrosine kinase (RTK) and TNFα pathways. The outcome provides evidence that the prevalent protease ADAM17 could attribute to cancer signaling regulation though the shedding of various inflammatory and oncogenic molecules. We have also exploited the analogues of the existing inhibitors, with an aim at discovering a potent molecule, which could be repurposed as a drug against ADAM17 inflicted cancer progression. Upon stringent screening, we delineated our choice into two specific compounds (I6 and I9; analogues of IK862, a type of y-lactam hydroxamates), possessing the lowest binding energy (–9.1 Kcal/mol), stable MD-simulation studies and superior pharmacodynamic properties. The current information illustrates the avenue to persuade further research on targeting ADAM17 with small molecular compounds (I6 and I9) in cancer therapeutics. Communicated by Ramaswamy H. Sarma
MPEC 2023-Q05 : 2019 CU1
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Chiral observables and S-duality in N = 2* U(N) gauge theories
Creators: name: Ashok, S. K.
name: Billo, M.
name: Dell'Aquila, E.
name: Frau, M.
name: Lerda, A.
name: Moskovic, M.
name: Raman, M.
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study N = 2* theories with gauge group U(N) and use equivariant localization to calculate the quantum expectation values of the simplest chiral ring elements. These are expressed as an expansion in the mass of the adjoint hypermultiplet, with coefficients given by quasi-modular forms of the S-duality group. Under the action of this group, we construct combinations of chiral ring elements that transform as modular forms of definite weight. As an independent check, we confirm these results by comparing the spectral curves of the associated Hitchin system and the elliptic Calogero-Moser system. We also propose an exact and compact expression for the 1-instanton contribution to the expectation value of the chiral ring elements.
description: 37 pages
Perfil clínico epidemiológico de pacientes con reacciones adversas a fármacos antirretrovirales
Creators: name: Miguel Cruz, Andres
name: Solis Solano, Sandra Silvia
name: Papaqui Limon, Elizabeth
name: Ramirez Sánchez, Jorge Manuel
Publisher: name: IBN SINA
Year: 2023

description: Objetivo: identificar el perfil clínico-epidemiológico de pacientes con reacciones adversas a fármacos antirretrovirales en la UNEME CAPASITS Puebla en el periodo 2015-2018. Materiales y métodos: estudio observacional, descriptivo, transversal y retrospectivo, en el que fueron incluidos 109 casos de un muestreo aleatorio simple de 188 expedientes que cumplieron con los criterios de inclusión: pacientes de 18-60 años de edad bajo tratamiento antirretroviral con confirmación de reacciones adversas a fármacos antirretrovirales. Las variables estudiadas fueron clasificadas en: tiempo, lugar, persona, clínicas y bioquímicas, para poder identificar tanto el perfil epidemiológico como clínico, de los datos recabados de cada uno de los expedientes. Resultados: Los resultados muestran una prevalencia de 57.98% de reacciones adversas a antirretrovirales, en las que el 57.8% son reacciones leves y 42.2% moderadas. De acuerdo al tiempo de presentación fueron reacciones agudas 90.8% y crónicas 9.2%. Las manifestaciones clínicas primarias que se presentaron en su mayoría fueron rash 44%, mareo 29.4% y lesiones maculopapulosas generalizadas 29.4%. Conclusiones: La prevalencia de reacciones adversas tiene un predominio de tipo dermatológicas. Se deben realizar estudios posteriores con una búsqueda de factores de riesgo asociados a las distintas manifestaciones clínicas presentadas.
description: IBN SINA, Vol. 14 Núm. 2 (2023): Vol. 14, Núm. 2, agosto-diciembre, 2023
Weak measurements and supraluminal communication
Creators: name: Belinsky, A. V.
name: Zhukovsky, A. K.
Publisher: name: arXiv
Year: 2016
Subjects: subject: General Physics (physics.gen-ph)
subject: FOS: Physical sciences

description: There is suggested a version of the experiment with a correlated pair of particles in the entangled state. The experiment demonstrates that, in the case of weak and/or non-demolition measurements of one of the particles, it is possible to transmit information with a speed not limited by velocity of light.
description: 4 figures