cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
THE EFFECT OF A NURSE-DRIVEN PROTOCOL ON THE INCIDENCE OF ASPIRATION PNEUMONIA IN A TERTIARY HEALTHCARE SYSTEM
Creators: name: Ramsey, Cory
Publisher: name: Zenodo
Year: 2021
Subjects: aspiration pneumonia
hospital-acquired pneumonia,
nurse-driven protocol
clinical practice guidelines

description: A nurse-driven protocol was developed and pilot tested to evaluate its effectiveness in preventing the occurrence of hospital-acquired aspiration pneumonia (AP) in a major tertiary healthcare system in Southern California. The project was divided into two distinct stages. The first stage was a methodological study that focused on the development of the protocol. The second stage involved testing via a pilot study. The Plan, Do, Study, Act Model for process improvement was utilized and both retrospective and prospective data were analyzed. A one-hundred percent sampling technique was used, and 134 patients (ages 18-95) hospitalized in the inpatient medical, surgical, critical care, and acute spinal cord injury units met protocol criteria. Patients admitted to these acute care settings with a community-acquired AP were excluded from the study. Approximately 231 registered nurses were trained. The outcome measures of interest were the frequency of AP, adherence to the protocol requirements, timeliness in initiating the protocol, AP protocol usage, and the nurses’ level of knowledge. Results showed a decrease in the number of AP from seven to two comparing the same months (November, December, January, February, and March) 12 months before the implementation of the protocol to five months after protocol implementation. Implications were made for nurses’ knowledge level, competency, and commitment for a systematic implementation of the APNP. Keywords: aspiration pneumonia, hospital-acquired pneumonia, nurse-driven protocol, clinical practice guidelines
Development of metformin tablet that mimics the circadian variation of glucose levels
Creators: name: Rajab, Mazen
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2013
Subjects: subject: Metformin
subject: Arzneimittelentwicklung
subject: Online-Publikation
subject: Hochschulschrift
subject: 615
subject: 610

description: Metformin (MET) ist das Mittel der Wahl zur Behandlung von Patienten mit Typ-2-Diabetes. Das Ziel dieser Arbeit bestand in der Entwicklung einer Tablette für MET mit einem Freisetzungsprofil, das der zirkadiane Variation der Blutzuckerwerte folgt (Arbeitshypothese). Um die Tabletten herzustellen wurden Stearinsäure (SA) und Gummi aus Tamarindensamen (TSG) mit Hydroxypropylmethylcellulose (HPMC) und Polyvinylpyrrolidon (PVP) gemischt. Zur Messung der Haftkraft wurde ein neuer Apparat gebaut, der die Scherkraft horizontal misst. Ein statistischer Versuchsplan wurde verwendet, um die Auswirkungen der verschiedenen Polymere zu untersuchen. Der Herstellungsprozess wurde optimiert. Die Arbeitshypothese wurde bestätigt. SA wurde zur Kontrolle der Freigabe qualifiziert. Die Polymere konnten zur Einstellung der Quellung und MET-Freigabe dienen. Die kombinatorischen Effekte der Polymere und die Wechselwirkung zwischen HPMC und PVP wurden verifiziert. Die in-vitro-Ergebnisse wurden teilweise durch eine Pilotstudie der MET Bioverfügbarkeit in gesunden Probanden bestätigt.
description: Metformin (MET) is considered as the first-line treatment of type 2 diabetes patients. The objective of this work was to develop a tablet of MET with a release profile that follows the circadian variation of glucose levels (working hypothesis). Stearic acid (SA) and tamarind seed gum (TSG) were blended with hydroxypropyl methylcellulose (HPMC) and Polyvinylpyrrolidone (PVP) to prepare the tablets. A new apparatus to measure adhesion was built applying shear force horizontally. Simplex lattice experimental design was used to study effects of polymer compositions. The manufacturing process was optimized. The working hypothesis was confirmed and SA was qualified as release controller. The polymers were found adjusting swelling and MET release. Combinatorial effects of polymers and the interaction between HPMC and PVP were verified. Results of in vitro performance of the tablets were partially confirmed by a pilot study of MET bioavailability in healthy human volunteers.
Conditional Sampling for Max-Stable Processes with a Mixed Moving Maxima Representation
Creators: name: Oesting, Marco
name: Schlather, Martin
Publisher: name: arXiv
Year: 2012
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60G70 (Primary) 60D05 (Secondary)

description: This paper deals with the question of conditional sampling and prediction for the class of stationary max-stable processes which allow for a mixed moving maxima representation. We develop an exact procedure for conditional sampling using the Poisson point process structure of such processes. For explicit calculations we restrict ourselves to the one-dimensional case and use a finite number of shape functions satisfying some regularity conditions. For more general shape functions approximation techniques are presented. Our algorithm is applied to the Smith process and the Brown-Resnick process. Finally, we compare our computational results to other approaches. Here, the algorithm for Gaussian processes with transformed marginals turns out to be surprisingly competitive.
description: 35 pages; version accepted for publication in Extremes. The final publication is available at http://link.springer.com
Directed expression of dominant-negative p73 in mouse hearts
Creators: name: Zhang, Ying
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2012
Subjects: subject: Online-Publikation
subject: Hochschulschrift
subject: 611

description: Herzmuskelzellen von Säugetieren verlieren in der Perinatalzeit die Fährigkeit zu Proliferation und Zellteilung. In der Vergangenheit konnte gezeigt werden, dass bei der Aufrechterhaltung dieser kardiomyozytären Zellzyklus-Blockade p53 eine wichtige Rolle spielt. p53 stellt jedoch einen typischen Tumor-Suppressor dar, so dass die p53-Hemmung mit dem Risiko der Tumor-Induktion verbunden ist. p73 stellt ein Mitglied der p53-Familie dar, das in struktureller und funktioneller Hinsicht p53 sehr ähnlich ist. Im Gegensatz zu p53 stellt p73 keinen typischen Tumor-Suppressor dar. Es konnte gezeigt werden, dass die Expression einer dominant-negativen Isoform von p73 (p73DD) die p53/p73-Signalkaskade inhibiert. Im Rahmen der hier vorgestellten Untersuchung wurde untersucht, inwiefern die Expression von p73DD den Wiedereintritt von Kardiomyozyten in den Zellzyklus ermöglicht. Zur Expression von p73DD wurden rekombinante Adenoviren konstruiert. Mittels der viralen Vektoren wurde p73DD in neonatalen Herzen von Mäusen exprimiert. Die Expression von p73DD resultierte bei den Tieren nach 3 und 14 Tagen in einem signifikanten Anstieg der relativen Herzgewichte. p73DD führte zur vermehrten Proliferation von Kardiomyozyten (BrdU-Inkorporation, Phosphorylierung von Histon3, Expression von AuroraB). Die Proliferation war nicht von vermehrten Kardiomyozyten-Apoptosen begleitet. Als molekularer Mechanismus der Proliferationssteigung lässt sich die Hemmung des p53-abhängig CDK-Inhibitors p21WAF bei gleichzeitiger Induktion von D-Cyclinen, Cyclin A, B2 und E nachweisen. Des Weiteren zeigte sich, dass p73DD auch zur Proliferation von adulten Kardimyozyten führt. p73DD könnte somit einen viel versprechenden Kandidaten zur Stimulation der Proliferation von Kardiomyozyten im Rahmen regenerativer Therapieansätze darstellen.
Pharmaceutical government - an ethnography of stock-outs and the institutionalization of free access to ART in Uganda
Creators: name: Park, Sung-Joon
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2014
Subjects: subject: 615

description: Die Dissertation untersucht Versorgungsunsicherheiten in der HIV-Behandlung in Uganda. Diese Versorgungsunsicherheiten werden in Uganda mit dem englischen Begriff stock-out bezeichnet. Die vorliegende Dissertation analysiert diese Versuchungsunsicherheiten durch eine empirische Untersuchung von Lieferengpässen und Versorgungskrisen im Zeitraum 2009 bis 2011. Der Fokus auf Versorgungsunsicherheiten thematisiert die wissenschaftlichen und infrastrukturellen Bedingungen einer normalen Lebensführung mit HIV, die mit der Institutionalisierung des freien Zugangs zu HIV-Medikamenten verbunden sind. Die Therapie der chronischen Krankheit macht eine regelmäßige Einnahme von antiretroviralen Medikamenten erforderlich. Die empirische Analyse der Medikamentenknappheit zeigt, dass Versorgungsunsicherheit sowohl als eine Rationalisierung der Therapie als auch eine Rationalisierung der Knappheit von Medikamenten zu verstehen ist. Darüber hinaus zeigt die vorliegende Dissertation, dass Medikamentenknappheit in Uganda Teil einer permanenten Neuorientierung und Reorganisation der HIV-Krise ist, die sich an den ständig verändernden Bedingungen der Versorgung ausrichtet.
description: This dissertation examines the stock-out of antiretrovirals in Uganda. It relates these stock-outs to the production of order and disorder - normalcy and crisis - in the AIDS epidemic. Between 2009 and 2011, numerous clinics in various places in Uganda were running out of antiretrovirals. The subsequent rationing of antiretrovirals gave rise to a number of ethical and moral dilemmas that will be discussed here in order to generalize more broadly on the social and scientific prerequisites of a ‘normal life’ with HIV. More than for other pharmaceuticals, the expectation that antiretrovirals can enable a ‘normal life’ with HIV, regardless of where one lives, is intricately linked with the trust that these life-prolonging medicines will be supplied permanently and without any interruptions. The stock-outs examined in this thesis show how people move between the AIDS crisis and normalcy by constantly fixing institutional mechanisms to scale-up access to treatment, maintain HIV as a chronic illness, and more importantly in dealing with the underlying scarcity of antiretrovirals. The continuous recalibration of treatment leads to a permanent reorganization of the AIDS crisis around the supply of antiretrovirals.
Professional support for bilingual language acquisition in children with developmental disabilities : a survey of speech-language pathologists in British Columbia, Canada
Creators: name: Stahl, Hillary Eileen
Publisher: name: University of British Columbia
Year: 2014

description: In a multicultural country, bilingualism can benefit many children, and be a necessity for some. However, support for bilingualism is not always a priority for children with developmental disabilities. Recent research has at least partially contradicted the ‘common sense’ view that bilingualism is detrimental to or unrealistic for these children. This study surveyed 42 speech-language pathologists from British Columbia, Canada to determine the extent to which children with developmental disabilities are exposed to languages other than English in professional settings. Questions considered two language learning scenarios: English language learners (ELLs) and optional second language learners (e.g. French immersion students). The questions probed access to language programs in the education system, as well as the languages used for assessment and treatment. Results showed that the severity of diagnosis impacted inclusion in language programs, most notably for optional second language learners. However, severity did not appear to play a role in the language of assessment and treatment. The opinions of the SLPs also differed significantly from their practices, showing that they would like to see more access to bilingual services than is currently the case.
“Solidified liquid lipids” for oral solid dosage forms - characterisation and processing
Creators: name: Kutza, Claudia
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2016
Subjects: subject: 615

description: Etwa 40 % der in der Entwicklung befindlichen Arzneistoffkandidaten sind schwer wasserlöslich, was eine geringe und variable Bioverfügbarkeit zur Folge hat. Lipid-Adsorbate sind vielversprechende Formulierungssysteme für lipophile Arzneistoffe, wobei die Erhöhung der Bioverfügbarkeit mit den Vorteilen der festen Arzneiform kombiniert wird. Es war das Ziel unter Verwendung der Hilfsstoffe Fujicalin, Neusilin US2 und Neusilin UFL2 Adsorbate herzustellen und die Wechselwirkung zwischen Oberfläche und Lipidsystem mittels NMR-Relaxometrie, ESR und Fluoreszenz-Imaging zu charakterisieren. Die Herstellung erfolgte mit Mörser bzw. SpeedMixer DAC 150 SP. Beide Neusilin-Hilfsstoffe adsorbierten mittelkettigeTriglyceride stärker als Fujicalin und führten zu einer Erhöhung der Mikropolarität. Die Freisetzung eines selbst-mikroemulgierenden Systems wurde mittels Fluoreszenzanalytik und NMR-Spektroskopie untersucht und ergab eine reduzierte Freisetzung des Neusilin US2 Adsorbats.
description: Approximately 40 % of new chemical entities are poorly water soluble resulting in a low and variable bioavailability. Lipid adsorbates are promising formulation systems for lipophilic drugs comprising the bioavailability enhancement with the advantage of solid dosage forms. It was the aim to prepare adsorbates from the excipients Fujicalin, Neusilin US2 and Neusilin UFL2 and to characterise the interactions between surface and the liquid lipid formulation system by means of NMR relaxometry, ESR and multispectral fluorescence imaging. The preparation was done by mortar and SpeedMixer DAC 150 SP. It was shown that both Neusilin excipients lead to a stronger adsorption of medium chain triglycerides and a higher micropolarity compared to Fujicalin. The release of a self-microemulsifying system was investigated by means of fluorescence analysis and NMR spectroscopy and resulted in a reduced release from Neusilin US2.
Orbit-based dynamical models of the Sculptor dSph galaxy
Creators: name: Breddels, Maarten A.
name: Helmi, A.
name: Bosch, R. C. E. van den
name: van de Ven, G.
name: Battaglia, G.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We have developed spherically symmetric dynamical models of dwarf spheroidal galaxies using Schwarzschild's orbit superposition method. This type of modelling yields constraints both on the total mass distribution (e.g. enclosed mass and scale radius) as well as on the orbital structure of the system (e.g. velocity anisotropy). This method is thus less prone to biases introduced by assumptions in comparison to the more commonly used Jeans modelling, and it allows us to derive the dark matter content in a robust way. Here we present our results for the Sculptor dwarf spheroidal galaxy, after testing our methods on mock data sets. We fit both the second and fourth velocity moment profile to break the mass-anisotropy degeneracy. For an NFW dark matter halo profile, we find that the mass of Sculptor within 1 kpc is M_1kpc = 1.03 \pm 0.07 x 10^8 Msol, and that its velocity anisotropy profile is tangentially biased and nearly constant with radius. The preferred concentration (c ~ 15) is low for its dark matter mass but consistent within the scatter found in N-body cosmological simulations. When we let the value of the central logarithmic slope α vary, we find that the best-fit model has α = 0, although an NFW cusp or shallower is consistent at 1 σ confidence level. On the other hand, very cuspy density profiles with logarithmic central slopes α < -1.5 are strongly disfavoured for Sculptor.
description: 18 pages, 12 figures, accepted by MNRAS http://mnras.oxfordjournals.org/content/433/4/3173
Additional file 1 of LncRNA GAS6-AS1 facilitates tumorigenesis and metastasis of colorectal cancer by regulating TRIM14 through miR-370-3p/miR-1296-5p and FUS
Creators: name: Chen, Qing
name: Zhou, Lin
name: Ma, De
name: Hou, Juan
name: Lin, Yuxin
name: Wu, Jie
name: Tao, Min
Publisher: name: figshare
Year: 2022
Subjects: Biophysics
Cell Biology
Molecular Biology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Additional file 1: Table S1. Primers.
Morphologisch-funktionelle Untersuchungen von pro-Nerve-Growth-Factor, Nerve-Growth-Factor und Tumornekrosefaktor-α an der Augenoberfläche und beim Pterygium oculi
Creators: name: Pfütze, Michael Daniel
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2012
Subjects: subject: Online-Publikation
subject: Hochschulschrift
subject: 611

description: Das Flügelfell ist eine invasiv wachsende, stark durchblutete Neoplasie, unklarer Pathogenese, am ehesten limbalen Ursprungs. Risikofaktoren sind tangentiale UV-Strahlung, chronische Mikrotraumata und Entzündungen. Wir untersuchten NGF, seine Vorstufe pro-NGF sowie TNFα hinsichtlich ihrer wachstumssteigernden und migrationsfördernden Effekte an cornealen (HCE) und konjunktivalen (HCjE) Epithelzelllinien. NGF und pro-NGF senkten das Zellwachstum signifikant, wohingegen TNFα das Wachstum förderte. Alle drei Faktoren hatten keinen Einfluss auf die Zellmotilität. Histologische Untersuchungen humaner Proben von Limbus, Horn- und Bindehaut sowie Pterygien zeigten insbesondere epithelial Vorkommen von pro-NGF und TNFα an. An HCE-Zellen konnten alle drei Faktoren nachgewiesen werden, in HCjE nur NGF und TNFα. Erhöhte pterygiale Sekretion von NGF und pro-NGF könnten eine Art körpereigener Abwehrmechanismus darstellen, der das Wachstum des Flügelfells bremsen soll.
description: A pterygium is an invasive, highly vascularized growth, thought to arise from proliferating limbal epithelial stem cells. Its pathogenesis is uncertain. Environmental factors such as UV-light, chronic irritation, and inflammation are causative factors. We examined NGF, its precursor pro-NGF and TNFα, with regard to cell proliferation and motility effects on corneal (HCE) and conjunctival (HCjE) epithelial cell lines as well as in pterygia. Proliferation of HCE and HCjE was significantly inhibited after stimulation with NGF/pro-NGF whereas TNFα increases cell proliferation. All three factors had no effect on cell motility. Histologic investigation of human samples from limbus, cornea, conjunctiva and primary pterygia revealed presence of pro-NGF and TNFα especially in epithelial cells. In cells all three factors could be visualized in HCE whereas in HCjE only NGF/TNFα was detectable. Increased secretion of NGF/pro-NGF in pterygium may function in blocking growth of the pterygium itself.
Additional file 2 of LncRNA GAS6-AS1 facilitates tumorigenesis and metastasis of colorectal cancer by regulating TRIM14 through miR-370-3p/miR-1296-5p and FUS
Creators: name: Chen, Qing
name: Zhou, Lin
name: Ma, De
name: Hou, Juan
name: Lin, Yuxin
name: Wu, Jie
name: Tao, Min
Publisher: name: figshare
Year: 2022
Subjects: Biophysics
Cell Biology
Molecular Biology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Additional file 2: Table S2. Characteristics of TCGA-COAD patients.
Forward-Backward SDEs driven by Lévy Processes and Application to Option Pricing
Creators: name: Pereira, Rui Sá
name: Shamarova, Evelina
Publisher: name: arXiv
Year: 2012
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: Recent developments on financial markets have revealed the limits of Brownian motion pricing models when they are applied to actual markets. Lévy processes, that admit jumps over time, have been found more useful for applications. Thus, we suggest a Lévy model based on Forward-Backward Stochastic Differential Equations (FBSDEs) for option pricing in a Lévy-type market. We show the existence and uniqueness of a solution to FBSDEs driven by a Lévy process. This result is important from the mathematical point of view, and also, provides a much more realistic approach to option pricing.
description: 20 pages, no figures
Analyse von Polymorphismen im MDMX-Gen und deren Einfluss auf die Entstehung und Progression von Ovarialkarzinomen
Creators: name: Pempe, Christina
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2013
Subjects: subject: Online-Publikation
subject: Hochschulschrift
subject: 611

description: In dieser Arbeit sollte der Einfluss von SNPs im MDMX-Gen auf die Entstehung und den Krankheitsverlauf von Ovarialkarzinompatientinnen untersucht werden. Analysiert wurden die SNPs rs3789052 (SNP9518), rs1563828 (SNP31826) und rs4252697 (SNP16620) Für den SNP9518 zeigte sich ein 10 Jahre früheres Diagnosealter, wenn ein homozygotes C-Allel vorlag (p=0,046). Ebenfalls konnte für den SNP16620 nachgewiesen werden, dass Patientinnen mit C/C-Genotyp 6 Jahre früher erkrankten (p=0,022). Für den SNP31826 konnte bei Patientinnen mit homozygotem Minor-Allel ein 5 Jahre früheres Erkrankungsalter ermittelt werden (p=0,087). Diese Unterschiede bestehen nur bei Tumoren ohne ER-Expression. Frauen mit SNP16620 und C/C-Genotyp überlebten 22 Monate länger als Frauen mit mindestens einem T-Allel (p=0,027). Auch für Patientinnen mit dem SNP31826 wurde eine 24 Monate längere Überlebenszeit ermittelt, wenn mindestens ein Minor-Allel vorlag (p=0,05). Insgesamt zeigen die Ergebnisse, dass SNPs im MDMX-Gen den p53-Signalweg abschwächen und sowohl die Tumorentstehung, als auch den Krankheitsverlauf von Ovarialkarzinompatientinnen beeinflussen.
description: The aim of the dissertation was to examine the influence of SNPs in the MDMX-gene on the age of onset and the survival of patients with ovarian cancer. The SNPs rs3789052 (SNP9518), rs1563828 (SNP31826) and rs4252697 (SNP16620) were analysed. It showed for the SNP9518 a ten-year earlier age at diagnosis, when a homozygous C-allele existed (p=0,046). For the SNP16620 could be proved that female patients with the C/C genotype fell ill six years earlier (p=0,022). For the SNP31826 it was possible to find out a five-year earlier age of onset for female patients with homozygous minor allele (p=0,087). But these differences only exist with tumors without ER-expression. It shows that women with SNP16620 and C/C genotype survive 22 months longer (p=0,027). For patients with the SNP31826 and a homozygous minor allele was found out as well a 24 months longer time of surviving compared to patients having a G/G genotype (p=0,05). Altogether the results show that SNPs in the MDMX-gene result in a weakening of the p53-pathway and influence the age of onset as well as the survival of patients with ovarian cancer.
Testing the "Rescue Personality" (Supplemental Digital Content)
Creators: name: Gröpel, Peter
name: Gurnakova, Jitka
name: Sedlar, Martin
Publisher: name: figshare
Year: 2021
Subjects: subject: Applied Psychology
subject: 170109 Personality, Abilities and Assessment
subject: FOS: Psychology
subject: Personality, Social and Criminal Psychology

description: The study material (Supplemental Digital Content 1 and 2) and statistical details (Supplemental Digital Content 3 and 4) for the manuscript "Testing the Rescue Personality: Personality Variables as Predictors of Team Performance in Emergency Medical Services".
Additional file 3 of LncRNA GAS6-AS1 facilitates tumorigenesis and metastasis of colorectal cancer by regulating TRIM14 through miR-370-3p/miR-1296-5p and FUS
Creators: name: Chen, Qing
name: Zhou, Lin
name: Ma, De
name: Hou, Juan
name: Lin, Yuxin
name: Wu, Jie
name: Tao, Min
Publisher: name: figshare
Year: 2022
Subjects: Biophysics
Cell Biology
Molecular Biology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Additional file 3: Figure S1. The expression difference and prognosis of miRNAs that may bind to GAS6-AS1 from the TCGA database. A The expression difference of 15 miRNAs in TCGA-COAD dataset. B Kaplan–Meier analysis of overall survival of the miRNAs. ns: none significance, * P < 0.05, ** P < 0.01, **** P < 0.0001.
Have "Questions"? We Have A Structure For Them
Creators: name: Thomas, Wendy
name: Duffes, Guilaume
name: Johnson, Jon
Publisher: name: Zenodo
Year: 2016
Subjects: EDDI16
DDI
Metadata

description: The most significant area of DDI adoption since 2008 has been around the development, management, and use of Questions. The creation of question banks, development of tools to organize and field questionnaires, and interest in new and specialized means of data capture has fueled development in the DDI. For those of you that have "Questions" and want to do something with them this half-day tutorial will address the following:

Question structures in DDI:

	What have these structures been designed to support
	How do they work - with what types of questions?
	How can they be organized - grouping and questionnaires

Creating Question Banks:

	What features are used
	Where are problems - and how to deal with them
	Trade-offs between semantics and representation: the special case of question grids

Creating Questionnaires:

	Organizing question flows and adding content - instructions, statements, and visual display
	Managing the flow of data from capture to variable

Question development and management:

	Creating new questions
	Managing old questions
Holographic Imaging of Crowded Fields: High Angular Resolution Imaging with Excellent Quality at Very Low Cost
Creators: name: Schoedel, R.
name: Yelda, S.
name: Ghez, A.
name: Girard, J. H. V.
name: Labadie, L.
name: Rebolo, R.
name: Perez-Garrido, A.
name: Morris, M. R.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: We present a method for speckle holography that is optimised for crowded fields. Its two key features are an iterativ improvement of the instantaneous Point Spread Functions (PSFs) extracted from each speckle frame and the (optional) simultaneous use of multiple reference stars. In this way, high signal-to-noise and accuracy can be achieved on the PSF for each short exposure, which results in sensitive, high-Strehl re- constructed images. We have tested our method with different instruments, on a range of targets, and from the N- to the I-band. In terms of PSF cosmetics, stability and Strehl ratio, holographic imaging can be equal, and even superior, to the capabilities of currently available Adaptive Optics (AO) systems, particularly at short near-infrared to optical wavelengths. It outperforms lucky imaging because it makes use of the entire PSF and reduces the need for frame selection, thus leading to higher Strehl and improved sensitivity. Image reconstruction a posteriori, the possibility to use multiple reference stars and the fact that these reference stars can be rather faint means that holographic imaging offers a simple way to image large, dense stellar fields near the diffraction limit of large telescopes, similar to, but much less technologically demanding than, the capabilities of a multi-conjugate adaptive optics system. The method can be used with a large range of already existing imaging instruments and can also be combined with AO imaging when the corrected PSF is unstable.
description: Accepted for publication in MNRAS on 15 Nov 2012
The Great Difficulty of Making It to the End of the Month in the Italian Regions in the Period 2004-2021
Creators: name: Leogrande, Angelo
Publisher: name: Zenodo
Year: 2023

description: Istat calculates the great difficulty in making it to the end of the month. The variable is defined as the share of people in families who, when asked "Taking into account all available incomes, how does your family make it to the end of the month?" they choose the response mode "With great difficulty". The data refers to the period between 2004 and 2021 for the Italian regions.
Detektion und Charakterisierung von MDMX-Isoformen in humanen Ovarialtumoren
Creators: name: Löbel, Claudia
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2012
Subjects: subject: Online-Publikation
subject: Hochschulschrift
subject: 611

description: In dieser Arbeit wurde in einem Kollektiv von 34 postoperativ eingefrorenen ovariellen Tumorproben die Expression von MDMX-Transkripten untersucht. In 16 der 34 Tumorproben konnten zusätzlich zur bereits charakterisierten Variante MDMX-S zahlreiche neue MDMX-Transkriptvarianten identifiziert werden. Die Expression einer Isoform mit intaktem RING-Finger (MDMX-211) in MCF-7 Zellen (Wildtyp-p53) führt zu einer Stabilisierung von p53 und anschließend zu einer verstärkten p21-Expression. Die Behandlung der Zellen mit cis-Platin hat ein vermindertes p21-Level zur Folge, das durch die Einleitung der Apoptose erklärbar ist. Im Gegensatz dazu hat die Expression der Spleißvariante MDMX-Var6 mit intakter p53-Bindungsdomäne keinen Einfluss auf das p21-Level in MCF-7 Zellen. In Folge der cis-Platin-Behandlung der Zellen kommt es zu einem stärkeren Anstieg von p53. Dies ist jedoch transkriptionell inaktiv, da es nicht zur p53-vermittelten Aktivierung des p21-Promotors kommt.
description: In this study, we screened 34 snap frozen ovarian tumour samples for MDMX splice variants. In addition to MDMX-S, we identified numerous new MDMX transcripts in 16 of the 34 tumour samples. Two representatively chosen isoforms were characterized in more detail. We found that expression of the splice variant MDMX-211 – containing the complete RING-finger domain – in MCF-7 cells (wild-type p53) resulted in the stabilization of p53 and subsequently in the p53-mediated expression of p21. After treatment of these cells with cis-Platinum, a significant decrease of the p21-level was observed, suggesting a switch from cell cycle regulation to apoptosis. In contrast, the splice variant MDMX-Var6, with a complete p53-binding domain, does not have any impact on p21 expression. After addition of cis-Platin we observed complete suppression of the p53 induced p21 expression despite a strong increase of the p53-levels.
The University of Texas at Austin Landscape Master Plan & Design Guidelines
Creators: name: Committee, The Landscape Master Plan
Publisher: name: University of Texas at Austin
Year: 2014
Subjects: University of Texas at Austin
UT campus
landscape design
design guidelines
landscape architecture

description: The Landscape Master Plan is intended to encourage unity in the design of the campus landscape over time, so that the individually designed parts of the landscape relate properly to one another, regardless of when they are built. This document’s audience includes University staff, administrators and consultants employed to design the campus landscape. The Landscape Master Plan aligns with the Operational Recommendations of the Commission of 125, which calls for the coordination of facilities planning to maintain a “superior campus environment” that assists in the recruitment and retention of a talented faculty, and improves the student experience. The need for the Landscape Master Plan, its relationship to other campus plans, the planning process and relevant background information is explained in Section 1. Section 2 consists of a summary of Existing Conditions, and Sections 3, 4 and 5 include the Landscape Master Plan recommendations. Section 3 presents recommendations related to the overall structure of the campus landscape and guidelines related to the different landscape AREAS (Civic Landscapes, Streetscapes, Parklands, Connective Landscapes, Courtyards, Service Spaces, and Waller Creek) of the campus. Section 4 presents guidelines related to the various SYSTEMS of the campus landscape, and Section 5 presents recommended POLICIES to guide implementation of the campus landscape
Non-abelian symmetries of quasitoric manifolds
Creators: name: Wiemeler, Michael
Publisher: name: arXiv
Year: 2012
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 57S05, 57S15

description: A quasitoric manifold $M$ is a $2n$-dimensional manifold which admits an action of an $n$-dimensional torus which has some nice properties. We determine the isomorphism type of a maximal compact connected Lie-subgroup $G$ of $\text{Homeo}(M)$ which contains the torus. Moreover, we show that this group is unique up to conjugation.
description: 14 pages; presentation improved; accepted for publication in Muenster J. of Math
Investigations into the use of continuous shear wave measurements in geotechnical engineering
Creators: name: Styler, Mark Anthony
Publisher: name: University of British Columbia
Year: 2014

description: The research presented within this thesis covers the development of a means to continuously monitor shear waves in a laboratory triaxial apparatus and down-hole during seismic cone penetration. This work resulted from an investigation of ageing of Fraser River Sand using a bender element triaxial apparatus. Shear wave propagation times from bender elements were interpreted using published time domain and frequency domain techniques. These techniques provided similar results, but the variability exceeded the effect of ageing. The frequency domain and time domain techniques had different shortcomings. The two techniques could be combined to converge on a single frequency-dependent propagation time that was independent of the trigger signal waveform. This contribution was capable of resolving the small increase in shear wave velocity with age duration. The frequency domain component of the combined bender element technique could run continuously during an experiment. With this further contribution, it was possible to track the change in shear wave propagation time throughout an experiment. The continuous bender element testing was not observed to influence the effect of ageing. It was found that in Fraser River Sand ageing had a small effect on the shear wave velocity, no effect on the ultimate strength, and a significant effect on the shear stiffness over the intermediate small-strain range (observed from 0.01 to 1%). The normalized shear stiffness curve shifts to larger strains and becomes more brittle with ageing. The concepts of the developed continuous bender element method are not restricted to this equipment or even to just bender element testing. The continuous bender element method was adapted to down-hole seismic testing in the field. This contribution resulted in a continuous profile of the shear wave velocity during seismic cone penetration testing that is obtained without stopping the cone penetration. The developments in this thesis provide a continuous measure of the shear wave velocity through a laboratory experiment and a continuous profile with down-hole penetration depth, i.e. the shear wave velocity is measured every time the other parameters are taken.
Overcoming drug resistance by stimulus-sensitive drug delivery systems - a preclinical characterization of polymer-drug conjugates for the treatment of multi-drug resistant cancer
Creators: name: Heinrich, Anne-Kathrin
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2017
Subjects: subject: 615

description: Im Zuge dieser Arbeit wurden drei verschiedene Stimulus-sensitive polymere Arzneistoffträgersysteme untersucht. Es wurden Polymer-Konjugate mit reduktiver Arzneistofffreisetzung, Systeme mit einer Freisetzung durch lysosomale Enzyme und pH-abhängige Systeme untersucht. Die Konjugate zeigten eine ausgezeichnete Tumoranreicherung und eine Tumor-spezifische Freisetzung des Arzneistoffmodells. In einer Therapiestudie mit dem pH-sensitiven System konnte in multi-resistenten Tumor-Xenograft tragenden Mäusen eine Resistenzüberwindung bis hin zur vollständigen Tumorregression erreicht werden. Vergleichende Studien mit anderen multiresistenten Tumorzelllinien zeigten eine Tumor-Typ abhängige Wirksamkeit der Konjugate. Diese konnte in weiterführenden Untersuchungen auf das unterschiedliche Tumormikromilieu, sowie die Tumorsubstruktur zurückgeführt werden. Diese Untersuchungen haben gezeigt, dass das Mikromilieu und die strukturellen Tumor-Eigenschaften den Therapieerfolg beeinflussen können.
description: Within this thesis, three different polymeric stimulus-sensitive drug delivery systems were investigated: a reduction-sensitive conjugate, one with a drug release triggered by lysosomal enzymes and a pH-sensitive system. These conjugates showed excellent tumor accumulation and achieved a drug release exclusively at the tumor site. In a therapy study with the pH-sensitive conjugate an overcoming of drug resistance was achieved in multi-drug resistant tumor bearing mice. Comparative studies with other resistant tumor cell lines revealed a tumor-type dependent therapeutic efficacy for the conjugates. It could be ascribed to the different tumor microenvironment and tumor substructure which was confirmed in multiple further investigations. These important results indicate the necessity of an improved understanding on cancer heterogeneity and the influence of tumor microenvironment and substructure on the therapeutic success of the respective stimulus-sensitive drug delivery systems.
Additional file 4 of LncRNA GAS6-AS1 facilitates tumorigenesis and metastasis of colorectal cancer by regulating TRIM14 through miR-370-3p/miR-1296-5p and FUS
Creators: name: Chen, Qing
name: Zhou, Lin
name: Ma, De
name: Hou, Juan
name: Lin, Yuxin
name: Wu, Jie
name: Tao, Min
Publisher: name: figshare
Year: 2022
Subjects: Biophysics
Cell Biology
Molecular Biology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Additional file 4: Figure S2. The Representative images of the EdU, Scratch healing, and Transwell assays matched to Fig. 6. (scale bar: 200 μm for EdU assay, 50 μm for wound healing assay, 100 μm for Transwell assay).
Klinische Studie zur Validierung der Benefit/Risk Ratio von topisch appliziertem Hydrocortisonaceponat
Creators: name: Behr, Ulrike
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2014
Subjects: subject: Online-Publikation
subject: Hochschulschrift
subject: 615

description: Topische Glukokortikoide haben in der Dermatologie eine große Bedeutung in der Therapie akuter und chronisch-entzündlicher Dermatosen. Der immunsuppressiven, antiphlogistischen Wirkung stehen unerwünschte Wirkungen wie die Hautatrophie gegenüber. Dieses Verhältnis lässt sich durch die Benefit/Risk Ratio (BRR) objektivieren. Im Rahmen einer monozentrischen, doppelblinden und randomisierten Studie wurde die BRR von Hydrocortisonaceponat (HCA) im Vergleich zum steroidfreien Vehikel und den Referenzsubstanzen Prednicarbat (PCB) und Betamethasonvalerat (BMV) ermittelt. Die Methode von McKenzie und Stoughton zur Ermittlung der Blanching Response (BR) wurde zugunsten der pharmakokinetischen Gesamtkonstellation abgewandelt. Die Applikation erfolgte länger und non-okklusiv. HCA und BMV vermitteln eine stärkere Blanching Response, weisen jedoch ein höheres atrophogenes Potential als PCB auf. Für die BRR ergeben sich keine relevanten Unterschiede. In der klinischen Anwendung scheinen HCA und BMV für die Initialtherapie und PCB für die Erhaltungstherapie geeignet zu sein. Möglicherweise kommt PCB für die Proaktive Therapie in Betracht.
description: Topical glucocorticoids in dermatology are of great importance in treatment of acute and chronic inflammatory dermatoses. The immunosuppressive and antiphlogistic effect is accompanied by unwanted effects like dermal atrophy. This Relation can be objectified by the benefit/risk ratio (BRR). Within a monocentric, double-blind, randomized, vehicle- and reference-controlled study, the BRR of hydrocortisone aceponate (HCA), its steroid-free vehicle and the reference substances prednicarbate (PCB) and betamethasone valerate (BMV) was investigated. The method of McKenzie und Stoughton has been adapted in favour of the pharmacokinetic overall conditions. The application took place in a longer period without occlusion. HCA and BMV show a stronger blanching response, but also a higher atrophogenic potential than PCB. There are no relevant differences in the BRR. For practical use, HCA and BMV seem to be suitable for initial therapy and PCB seems to be used for maintenance therapy, potencially for proactive therapy.
A study of the anisotropy associated with dipole asymmetry in heavy ion collisions
Creators: name: Jia, Jiangyong
name: Radhakrishnan, Sooraj K.
name: Mohapatra, Soumya
Publisher: name: arXiv
Year: 2012
Subjects: subject: Nuclear Theory (nucl-th)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The anisotropy associated with the initial dipole asymmetry in heavy ion collisions is studied via the two-particle relative azimuthal azimuthal angle (Δϕ=ϕ^a-ϕ^b) correlations, within a multi-phase transport model. For a broad selection of centrality, transverse momenta (pT^{a,b}) and pseudorapidity (η^{a,b}), a fitting method is used to decompose the anisotropy into a rapidity-even component, characterized by the Fourier coefficient v1, and a global momentum conservation component. The extracted v1 values are negative for pT<=0.7-0.9 GeV, reach a maximum at 2-3 GeV, and decreases at higher pT. The v1 values vary weakly with ηand centrality, but increases with collision energy and parton cross-section. The extracted global momentum conservation component is found to depend on Δη= η^a-η^b for Δη<3.
description: final published version
On the Etymologies of Kinnabari, Kinnamon, Kinawar et al.
Creators: name: Gheorghiu, Alexandru
Publisher: name: Zenodo
Year: 2021
Subjects: Ancient Greek, Sanskrit, Hattic language, Hurrian language, Sumerian language, Persian language, Iranian language, Indo-Iranian language, Akkadian language, Arabic language, Hebrew language, Classical Syriac, Urartan language, Urartian language, Bactrian, Old Chinese, Proto-Indo-European linguistics, Indo-European, Ancient Greece, Aegean, Athena, Ariadne, Crete, Thrace, Thracian language, Dacia, Dacian language, Latin language, Romanian language, Albanian language, English language, Anatolian languages, Etruscan language, Lemnian language, Hittite language, Luwian language, Mesopotamia, Sumer, Akkad, Syria, Anatolia, Iran, India, Pakistan, China, Eastern Mediterranean, Pelasgian, Peri-Indo-European, Anthropology, cinnabar, mercury, copper, coriander, garlic, snakes, snake bite remedies, anti-venom, comparative linguistics
Phoenician, Phoenicia, Proto-Balto-Slavic, Proto-Slavic, Proto-Germanic, Armenian language, Costoboci, Palaeo-Balkan, Proto-Albanian, Euphratic, Proto-Sumerian, Peri-Indo-European, Semi-Indo-European, Classical Greece, Kotys, Cotys, Kottyto, Cottyto, Thracian mythology, Thracian religion, Greek mythology, Greek religion, weaving goddess
Eteo-Cretan, mallow, melon, malva, sheep, history of spices, ethnobotany

description: A work which presents many new and important and very likely correct etymologies, and so likely elucidates a number of obscure words found in Ancient Greek, Sumerian, Sanskrit, Arabic, Persian, Hattic, Hurrian, as well as other ancient languages of Eurasia. Includes some discussion of and new information about Peri-Indo-European and Semi-Indo-European and Eteo-Indo-European (before Proto-Indo-European).
description: New greatly expanded eighth version, including a well-expanded and updated and detailed discussion of the Sumerian words, in addition to all the new information and new etymologies and new evidence throughout most of the text added in the 7th version, as well as an entirely new section concluding the work (which was added in the 7th version).
Hybrid bounds for automorphic forms on ellipsoids over number fields
Creators: name: Blomer, Valentin
name: Michel, Philippe
Publisher: name: arXiv
Year: 2011
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: We prove upper bounds for Hecke-Laplace eigenfunctions on certain Riemannian manifolds of arithmetic type. The manifolds under consideration are d-fold products of 2-spheres or 3-spheres, realized as adelic quotients of quaternion algebras over totally real number fields.
description: somewhat expanded version, to appear in J. Inst. Math. Jussieu
Proteinkonzentrationen im humanen okulären Surfactant System und deren Einfluss auf das trockene Auge
Creators: name: Posa, Andreas
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2013
Subjects: subject: Online-Publikation
subject: Hochschulschrift
subject: 611

description: Die Gewebe der Augenoberfläche und des Tränensystems unterliegen aufgrund ihres ständigen Kontaktes mit der Umwelt einer Fülle von exogenen Einflüssen, wie Mikroorganismen oder pathogen assoziierten Molekülen. Ein funktionelles Abwehrsystem ist daher unerlässlich zur Vermeidung von Infektionen oder Erkrankungen des Auges und des Tränensystems. In den letzten Jahren konnten die vier bislang bekannten Surfactant Proteine (SP-A, -B, -C, -D) an der Augenoberfläche und im Tränenapparat nachgewiesen werden. Die Surfactant Proteine besitzen in der Lunge lebensnotwendige immunologische und oberflächenaktive Funktionen, welche im Hinblick auf die Funktionalität und Stabilitätdes Tränenfilms eine bedeutende Rolle einnehmen könnten.
description: The dry eye is one of the most common illnesses of the eye surface. Patients suffer in particular from subjective symptoms which interfere with and reduce their quality of life. The hydrophobic surfactant proteins B (SP-B) and C (SP-C) are tightly bound to phospholipids. These proteins play important roles in maintaining the surface tension-lowering properties of pulmonary surfactant. Surfactant protein A (SP-A) and D (SP-D) are extremely hydrophilic and are thought to have a role in recycling surfactant and especially in improving host defense in the lung. Moreover, SPA supports the hydrophobic surfactant proteins during surfactant subtype assembly and inhibits secretion of lamellar bodies into the alveolar space. During recent years surfactant proteins have also been detected at locations outside the lung such as the lacrimal apparatus.
The obstacle problem for quasilinear stochastic PDEs: Analytical approach
Creators: name: Denis, Laurent
name: Matoussi, Anis
name: Zhang, Jing
Publisher: name: arXiv
Year: 2012
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: We prove an existence and uniqueness result for quasilinear Stochastic PDEs with obstacle (OSPDE in short). Our method is based on analytical technics coming from the parabolic potential theory. The solution is expressed as a pair $(u,ν)$ where $u$ is a predictable continuous process which takes values in a proper Sobolev space and $ν$ is a random regular measure satisfying the minimal Skohorod condition.
description: Published in at http://dx.doi.org/10.1214/12-AOP805 the Annals of Probability (http://www.imstat.org/aop/) by the Institute of Mathematical Statistics (http://www.imstat.org)