cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Disruption of embryonic ROCK signalling reproduces the sarcomeric phenotype of hypertrophic cardiomyopathy
Creators: name: Bailey, Kate E
name: MacGowan, Guy A
name: Tual-Chalot, Simon
name: Phillips, Lauren
name: Mohun, Tim J
name: Henderson, Deborah J
name: Arthur, Helen M
name: Bamforth, Simon D
name: Phillips, Helen M
Publisher: name: The Francis Crick Institute
Year: 2019
Subjects: Developmental Biology
Imaging
Model organisms

description: Sarcomeric disarray is a hallmark of gene mutations in patients with Hypertrophic Cardiomyopathy (HCM). However, it is unknown when detrimental sarcomeric changes first occur and whether they originate in the developing embryonic heart. Furthermore, Rho Kinase (ROCK) is a serine threonine protein kinase that is critical for regulating the function of several sarcomeric proteins and therefore, our aim was to determine if disruption of ROCK signalling during the earliest stages of heart development would disrupt the integrity of sarcomeres altering heart development and function. Using a mouse model in which the function of ROCK is specifically disrupted in embryonic cardiomyocytes we demonstrate a progressive cardiomyopathy that first appeared as sarcomeric disarray during cardiogenesis. This led to abnormalities in the structure of embryonic ventricular wall and compensatory cardiomyocyte hypertrophy during foetal development. This sarcomeric disruption and hypertrophy persisted throughout adult life, triggering left ventricular concentric hypertrophy with systolic dysfunction, and re-activation of foetal gene expression and cardiac fibrosis, all typical features of HCM. Taken together, our findings establish a novel mechanism for the developmental origin of the sarcomeric phenotype of HCM and suggest that variants in the ROCK genes or disruption of ROCK signalling could, in part, contribute to its pathogenesis.
Exponential decay for Constrained-degree percolation
Creators: name: Santos, Diogo C. dos
name: Silva, Roger W. C.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: We consider the Constrained-degree percolation model in random environment (CDPRE) on the square lattice. In this model, each vertex $v$ has an independent random constraint $κ_v$ which takes the value $j\in \{0,1,2,3\}$ with probability $ρ_j$. The dynamics is as follows: at time $t=0$ all edges are closed; each edge $e$ attempts to open at a random time $U_e\sim \mathrm{U}(0,1]$, independently of all other edges. It succeeds if at time $U_e$ both its end-vertices have degrees strictly smaller than their respective constraints. We obtain exponential decay of the radius of the open cluster of the origin at all times when its expected size is finite. Since CDPRE is dominated by Bernoulli percolation, such result is meaningful only if the supremum of all values of $t$ for which the expected size of the open cluster of the origin is finite is larger than 1/2. We prove this last fact by showing a sharp phase transition for an intermediate model.
description: 15 pages, 1 figure
Gauge transformations of Jacobi structures and contact groupoids
Creators: name: Das, Apurba
Publisher: name: arXiv
Year: 2018
Subjects: subject: Mathematical Physics (math-ph)
subject: Differential Geometry (math.DG)
subject: Symplectic Geometry (math.SG)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 17B63, 53C15, 53D10, 53D17, 53D35

description: We define gauge transformations of Jacobi structures on a manifold. This is related to gauge transformations of Poisson structures via the Poissonization. Finally, we discuss how the contact structure of a contact groupoid is effected by a gauge transformation of the Jacobi structure on its base.
description: 18 pages, revised version, comments are welcome
Trajectoire de demande d'aide d'hommes francophones ayant vécu l'abus sexuel durant l'enfance et/ou à l'adolescence
Creators: name: Rivet, Genève
Publisher: name: My University
Year: 2020

description: Cette recherche a pour but d’étudier les facteurs qui incitent les hommes ayant vécu des abus sexuels durant l’enfance et/ou à l’adolescence à consulter des services psychosociaux à l’âge adulte. La trajectoire de demande d’aide peut s’échelonner sur une longue période de temps et être influencée par plusieurs facteurs ; prise de conscience du problème à l’âge adulte, la rareté des services, un manque de motivation et la honte ressentie. Il existe très peu de services pour ces hommes et certains services généraux ne savent pas comment recevoir leurs demandes et les accompagner. Huit entretiens semi-dirigés ont été réalisés, portant particulièrement sur les répercussions des abus sexuels subis et sur leur processus de demande d’aide à l’âge adulte. À la lumière du modèle écosystémique de Bronfenbrenner et du processus de demande d’aide de Gross et McMullen, une analyse est proposée, tenant compte de l’ensemble des facteurs qui ont influencé la trajectoire de demande d’aide de ces hommes. Mots-clés : Abus sexuel durant l’enfance et/ou à l’adolescence, approche écosystémique, dévoilement, hommes, processus de demande d’aide, services d’aide.
Repeated clinical malaria episodes are associated with modification of the immune system in children
Creators: name: Yaw Bediako
name: Adams, Rhys
name: Reid, Adam J
name: Valletta, John Joseph
name: Ndungu, Francis M
name: Sodenkamp, Jan
name: Jedidah Mwacharo
name: Ngoi, Joyce Mwongeli
name: Domtila Kimani
name: Kai, Oscar
name: Wambua, Juliana
name: Nyangweso, George
name: Villiers, Etienne P De
name: Sanders, Mandy
name: Lotkowska, Magda Ewa
name: Lin, Jing-Wen
name: Manni, Sarah
name: Addy, John WG
name: Recker, Mario
name: Newbold, Chris
name: Berriman, Matthew
name: Bejon, Philip
name: Marsh, Kevin
name: Langhorne, Jean
Publisher: name: The Francis Crick Institute
Year: 2019
Subjects: subject: Model organisms
subject: Infectious Disease
subject: Immunology
subject: FOS: Clinical medicine

description: There are over 200 million reported cases of malaria each year, and most children living in endemic areas will experience multiple episodes of clinical disease before puberty. We set out to understand how frequent clinical malaria, which elicits a strong inflammatory response, affects the immune system and whether these modifications are observable in the absence of detectable parasitaemia.
Prospects of type-II seesaw at future colliders in light of the DAMPE $e^+ e^-$ excess
Creators: name: Sui, Yicong
name: Zhang, Yongchao
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The DAMPE $e^+ e^-$ excess at around 1.4 TeV could be explained in the type-II seesaw model with a scalar dark mater $D$ which is stabilized by a discrete $Z_2$ symmetry. The simplest scenario is the annihilation $DD \to H^{++} H^{--}$ followed by the subsequent decay $H^{\pm\pm} \to e^\pm e^\pm$, with both the DM and triplet scalars roughly 3 TeV with a small mass splitting. In addition to the Drell-Yan process at future 100 TeV hadron colliders, the doubly-charged components could also be produced at lepton colliders like ILC and CLIC in the off-shell mode, and mediate lepton flavor violating processes $e^+ e^- \to \ell_i^\pm \ell_j^\mp$ (with $i \neq j$). A wide range of parameter space of the type-II seesaw could be probed, which are well below the current stringent lepton flavor constraints.
description: 9 pages, 5 figures, minor changes, version to appear in PRD
title: ADCO, Cinquième cartulaire de Saint-Étienne de Dijon (1664), Cart. 28 (G 132), 258 folios, f. 00360
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: Corpus Burgundiae Medii Aevi

description: Cinquième cartulaire de Saint-Étienne de Dijon (1664), Archives départementales de la Côte-d'Or, Cart. 28 (G 132), 258 folios, f. 00360, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cinquième cartulaire de Saint-Étienne de Dijon (1664), Archives départementales de la Côte-d'Or, Cart. 28 (G 132), 258 folios, f. 00360, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Additional file 2 of IMRT in oral cavity cancer
Creators: name: Studer, Gabriela
name: Zwahlen, Roger A
name: Graetz, Klaus W
name: Davis, Bernard J
name: Glanzmann, Christoph
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Marine Biology
subject: Cancer

description: Authors’ original file for figure 2
Divergent kinase regulates membrane ultrastructure of the Toxoplasma parasitophorous vacuole
Creators: name: Tsebaot Beraki
name: Xiaoyu Hu
name: Malgorzata Broncel
name: Young, Joanna C
name: O'Shaughnessy, William J
name: Borek, Dominika
name: Treeck, Moritz
name: Reese, Michael L
Publisher: name: The Francis Crick Institute
Year: 2019
Subjects: subject: Biochemistry & Proteomics
subject: Infectious Disease
subject: Immunology
subject: FOS: Clinical medicine
subject: Cell Biology
subject: Computational & Systems Biology

description: Apicomplexan parasites replicate within a protective organelle, called the parasitophorous vacuole (PV). The Toxoplasma gondii PV is filled with a network of tubulated membranes, which are thought to facilitate trafficking of effectors and nutrients. Despite being critical to parasite virulence, there is scant mechanistic understanding of the network's functions. Here, we identify the parasite-secreted kinase WNG1 (With-No-Gly-loop) as a critical regulator of tubular membrane biogenesis. WNG1 family members adopt an atypical protein kinase fold lacking the glycine rich ATP-binding loop that is required for catalysis in canonical kinases. Unexpectedly, we find that WNG1 is an active protein kinase that localizes to the PV lumen and phosphorylates PV-resident proteins, several of which are essential for the formation of a functional intravacuolar network. Moreover, we show that WNG1-dependent phosphorylation of these proteins is required for their membrane association, and thus their ability to tubulate membranes. Consequently, WNG1 knockout parasites have an aberrant PV membrane ultrastructure. Collectively, our results describe a unique family of Toxoplasma kinases and implicate phosphorylation of secreted proteins as a mechanism of regulating PV development during parasite infection.
The effects of nucleosome core particle packaging on DNA charge transport
Creators: name: Bjorklund, Chad Christopher
Publisher: name: Washington State University
Year: 2006
Subjects: Charge transfer in biology -- Genetic aspects

description: Consequences of DNA oxidation can be critical to the healthy maintenance of genomic integrity. When left undetected or unrepaired, DNA oxidative lesions can contribute to various adverse health conditions including cancer, heart disease, and neuronal deterioration. Most DNA oxidative lesions are localized on guanine (G) residues due to the low ionization potential as compared to the other nucleotides found in DNA. One electron oxidation of G results in the formation of a guanine radical cation (G +), or an electron deficient hole, which then has several fates available to it. One fate is that it may react with a molecule in solvent (O2, H20, O2 -) to form an irreversible oxidative lesion. Another option for the G + is a nearly isoenergetic exchange with another G within a DNA base stack, thereby mobilizing the electron hole to a site other than where it originated. This mobile electron hole may then migrate over long distances on DNA (>200 ) before becoming irreversibly trapped. While this phenomenon has been extensively studied in B-form DNA systems, little has been done to explore the potential and/or consequences of these events in biological settings. I have taken the nucleosome core particle (NCP) as a biological model to investigate the dynamics of DNA charge transport (CT). Here I report the results of using an Anthraquinone (AQ) photooxidant to initiate DNA CT in NCPs using highly thermodynamic NCP positioning sequences (TG-motif and 601). My studies show that there are significant qualitative and quantitative differences in G damage distributions in both free DNA and reconstituted NCPs. I have also identified a unique DNA protein crosslink as a result of DNA CT. Additionally, I have observed a previously undiscovered phenomenon called protein mediated DNA CT. The results and interpretations of the data presented here will have profound impacts on future studies of DNA CT in biological systems.
Merged ionization/dissociation fronts in planetary nebulae
Creators: name: Henney, William J.
name: Williams, R. J. R.
name: Ferland, Gary J.
name: Shaw, Gargi
name: O'Dell, C. R.
Publisher: name: arXiv
Year: 2007
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The hydrogen ionization and dissociation front around an ultraviolet radiation source should merge when the ratio of ionizing photon flux to gas density is sufficiently low and the spectrum is sufficiently hard. This regime is particularly relevant to the molecular knots that are commonly found in evolved planetary nebulae, such as the Helix Nebula, where traditional models of photodissociation regions have proved unable to explain the high observed luminosity in H_2 lines. In this paper we present results for the structure and steady-state dynamics of such advection-dominated merged fronts, calculated using the Cloudy plasma/molecular physics code. We find that the principal destruction processes for H_2 are photoionization by extreme ultraviolet radiation and charge exchange reactions with protons, both of which form H_2^+, which rapidly combines with free electrons to undergo dissociative recombination. Advection moves the dissociation front to lower column densities than in the static case, which vastly increases the heating in the partially molecular gas due to photoionization of He^0, H_2, and H^0. This causes a significant fraction of the incident bolometric flux to be re-radiated as thermally excited infrared H_2 lines, with the lower excitation pure rotational lines arising in 1000 K gas and higher excitation H_2 lines arising in 2000 K gas, as is required to explain the H_2 spectrum of the Helix cometary knots.
description: 4 pages, accepted by ApJL, scheduled December 20 issue
Additional file 3 of IMRT in oral cavity cancer
Creators: name: Studer, Gabriela
name: Zwahlen, Roger A
name: Graetz, Klaus W
name: Davis, Bernard J
name: Glanzmann, Christoph
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Marine Biology
subject: Cancer

description: Authors’ original file for figure 3
title: 01_1495
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Mechanisms of base, mineral, and soil activation of persulfate for groundwater treatment
Creators: name: Corbin, Joseph Franklin
Publisher: name: Washington State University
Year: 2008
Subjects: Groundwater -- Purification

description: The purpose of this study was to examine mechanisms of base, mineral, and soil persulfate activation when used for ground water treatment by in situ chemical oxidation. Four base-activated persulfate systems (adjusting the pH to 12 and using molar ratios of 1:1, 2:1, or 3:1 base to persulfate) were studied using three reaction-specific probe compounds and two radical scavengers. Rapid degradation of oxidative probes occurred at pH 12, but minimal degradation of the reductive probe, carbon tetrachloride, was observed at pH 12. Degradation of all probe compounds occurred in molar ratios systems. The results of this research demonstrate that the reactivity of persulfate formulations increases with increasing base:persulfate ratios. The potential for 13 minerals to mediate the decomposition of persulfate and generate a reactive oxygen species was investigated. Reactions were conducted at 25?C using 2 g of minerals and 5 ml of 0.5 M sodium persulfate with the addition of oxidative, reductive, and nucleophilic probes. The decomposition of persulfate and the probes by minerals varied extensively. Most of the minerals mediated the decomposition of persulfate, but did not promote the generation of reactive oxygen species, although cobaltite, ilmenite, and pyrite did. The results demonstrate that most of the minerals evaluated do not activate persulfate. The decomposition of persulfate by 11 soils was investigated in order to observe the impact of these soils on pH and persulfate concentration. Reactions were conducted at 25?C using 10 g of soil and 20 mL of either 0.5 M or 0.1 M persulfate. Reactions were conducted using base:persulfate molar ratios of 1:1, 2:1, or 3:1 over 120 d. Decomposition of persulfate and pH varied greatly between soils, although not between 0.1 M and 0.5 M persulfate. A second set of experiments were conducted in which anisole was used a probe for the overall reactivity of the system. These experiments used 0.5 M persulfate in a 2:1 base:persulfate molar ratio and two soils. The results demonstrated a reduction in anisole destruction when the pH declined. This research demonstrated the importance of pH and soil properties in the use of persulfate treatments.
Modification of plant and yeast lipids by heterologous expression of protist, algal, and animal desaturases
Creators: name: Olsen, Rebecca Lynn
Publisher: name: Washington State University
Year: 2006
Subjects: Fatty Acids

description: Modification of lipids by expression of transgenes to alter levels of endogenous
description: fatty acids, and/or to produce novel fatty acids has long been a goal of plant researchers.
description: In this attempt, the identification of desaturases and other fatty acid modification
description: enzymes that can act in heterologous systems was undertaken. Tetrahymena species
description: Tetrahymena pyriformis and Tetrahymena thermophila have three endogenous fatty acid
description: desaturases, a Δ6, a Δ9, and a Δ12. To examine the activity of Tetrahymena enzymes, Δ6
description: and Δ9 desaturases were cloned from a T. thermophila cDNA library and modified for
description: expression in heterologous systems. Alignment of these proteins with known desaturases
description: revealed homology seen in conserved domains of these proteins. Desaturation was not
description: seen with the Δ9 desaturase and limited desaturation was seen with the Δ6. However,
description: desaturation was increased 10-fold when the Δ6 desaturase was co-expressed with a
description: cytochrome b5 from Arabidopsis thaliana. Further analysis of the desaturases of
description: Tetrahymena involved the cloning of the Δ12 desaturase homologs of both T. pyriformis
description: and T. thermophila which could account for the Δ14 desaturation of 20:1(11) to
description: 20:2(11,14) seen in Tetrahymena. Following the cloning of these desaturase cDNAs, the
description: codons were altered to allow for expression in three heterologous expression systems.
description: Desaturation was not seen in any of the systems until the codons were optimized and a
description: small amount of Δ12 desaturation was seen in yeast. With the overall goal of
description: modification of plant lipids by expression of desaturases two other cDNAs were
description: introduced into Arabidopsis, a Δ8 from E. gracilis, and a Δ9 from C. elegans.
description: Expression of the Δ8 with a seed-specific promoter resulted in the desaturation of
description: 20:1(11) to 20:2(8,11) in Arabidopsis seeds. The Δ9 from C. elegans was introduced into
description: Arabidopsis seeds plants to reduce the amount of 16:0 saturated fatty acid. Expression of
description: this desaturase with a seed-specific promoter resulted in a reduction of 16:0 from 10% to
description: around 3%. Overall this project highlights the issue that can arise from heterologous
description: expression of desaturases but also the results that can be obtained in alteration of
description: endogenous fatty acids by desaturase expression.
Low Cost Technical Solutions to Jump Start an Insider Threat Program
Creators: name: Silowash, George J
name: Spooner, Derrick
name: Costa, Daniel L.
name: Abrethsen, Michael
Publisher: name: Carnegie Mellon University
Year: 2016
Subjects: subject: 80309 Software Engineering
subject: FOS: Computer and information sciences

description: This technical note explores free and low cost technical solutions to help organizations prevent, detect, and respond to malicious insiders. The tools presented address the needs of organizations to have, at a minimum, user activity monitoring, data loss prevention, security information and event management, analytics, and a digital forensics and investigation capability. Implementing tools in all of these categories will help an organization have a successful insider threat program.
Förderung der Konzentration, sowie der sozialen, emotionalen und leistungsmotivationalen Integration exemplarisch am Beispiel eines Pflanzenrituales im integrativen Heilpädagogischen Unterricht
Creators: name: Lieberherr, Carmen
Publisher: name: Zenodo
Year: 2018
Subjects: Sonderpädagogik
Soziale Integration
Masterarbeit

description: Ziel dieser Masterarbeit war es, ein Ritual zur Förderung der Konzentration, sowie der sozialen, emotionalen und leistungsmotivationalen Integration von Schulkindern mit Förderbedarf zu entwickeln. Die relevanten Ritualeigenschaften wurden zusammengefasst und exemplarisch am Beispiel eines Pflanzenrituales für den integrativen Heilpädagogischen Unterricht umgesetzt. Das entwickelte Produkt umfasst eine Beschreibung der Ritualgestaltung, sowie Informationen und Anschauungsmaterial für eine Auswahl von Pflanzen. Die Auswirkungen des Rituales wurden mit drei Forschungsmethoden untersucht. Es konnten eine klare Tendenz zur Steigerung der Konzentration und eine sehr leichte zur Steigerung der drei Dimensionen der Integration aufgezeigt werden. Um klarere Ergebnisse bezüglich der Integration zu erzielen, müssten die Testphasen ausgeweitet und die Forschungsmethoden angepasst werden.
Note on bouncing backgrounds
Creators: name: de Haro, Jaume
name: Pan, Supriya
Publisher: name: arXiv
Year: 2018
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The theory of inflation is one of the fundamental and revolutionary developments of modern cosmology that became able to explain many issues of early universe in the context of the standard cosmological model (SCM). However, the initial singularity of the universe, where physics is indefinite, is still obscure in the combined `SCM+inflation' scenario. An alternative to `SCM+inflation' without the initial singularity is thus always welcome, and bouncing cosmology is an attempt of that. The current work is thus motivated to investigate the bouncing solutions in modified gravity theories when the background universe is described by the spatially flat Friedmann-Lemaitre-Robertson-Walker (FLRW) geometry. We show that the simplest way to obtain the bouncing cosmologies in such spacetime is to consider some kind of Lagrangians whose gravitational sector depends only on the square of the Hubble parameter of the FLRW universe. For these modified Lagrangians, the corresponding Friedmann equation, a constraint in the dynamics of the universe, depicts a curve in the phase space $(H,rho)$, where $H$ is the Hubble parameter and $rho$ being the energy density of the universe. As a consequence, a bouncing cosmology is obtained when this curve is closed and crosses the axis $H = 0$ at least twice, and whose simplest particular example is the ellipse depicting the well-known holonomy corrected Friedmann equation in Loop Quantum Cosmology (LQC). Sometimes, a crucial point in such theories is the appearance of the Ostrogradski instability at the perturbative level, however, fortunately enough, in the present work as long as the linear level of perturbations is concerned, this instability does not appear but such instability may appear at the higher-order of perturbations.
description: Version accepted for publication on PRD
D9.2 Exploitation Plan Update
Creators: name: Georgopoulos, Konstantinos
Publisher: name: Zenodo
Year: 2023
Subjects: ReCiPSS
Circular Economy
Exploitation plan

description: This report describes the updated exploitation plan for the ReCiPSS project, a funded project by the European Union’s Programme Horizon 2020, under Grant Agreement number 776577. The Deliverable 9.2 “Exploitation plan update” is related to the tasks 9.1 “Developing the exploitation strategy and plan” and 9.2 “Developing business cases and upscaling plans”. The deliverable report provides the final common exploitation strategy and clear individual exploitation plan and exploitation trends within the consortium, as well as the communication and sustainability strategy to set up the basis for the future viability of the results developed in the ReCiPSS project.
Life-Cycle Models for Survivable Systems
Creators: name: Linger, Richard C.
name: Lipson, Howard
name: McHugh, John
name: Mead, Nancy R.
name: Sledge, Carol A.
Publisher: name: Carnegie Mellon University
Year: 2002
Subjects: subject: 80309 Software Engineering
subject: FOS: Computer and information sciences

description: Today's large-scale, highly distributed, networked systems improve the efficiency and effectiveness of organizations by permitting whole new levels of organizational integration. However, such integration is accompanied by elevated risks of intrusion and compromise. Incorporating survivability capabilities into an organization's systems can mitigate these risks. Current software development life-cycle models are not focused on creating survivable systems, and exhibit shortcomings when the goal is to develop systems with a high degree of assurance of survivability. If addressed at all, survivability issues are often relegated to a separate thread of project activity, with the result that survivability is treated as an add-on property. For each life-cycle activity, survivability goals should be addressed, and methods to ensure survivability incorporated. This report explains survivability concepts, describes a software development life-cycle model for survivability, and illustrates techniques that can be applied during new development activities to support survivability goals. It also describes a software life-cycle model and associated activities to support survivability goals for systems based on commercial off-the-shelf products
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Creators: name: "Ð¤ÑÐ½Ð´Ð°Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÐµ Ð¸ Ð¿ÑÐ¸ÐºÐ»Ð°Ð´Ð½ÑÐµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð² Ð¾Ð±Ð»Ð°ÑÑÐ¸ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ, ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÐºÐ¸ Ð¸ ÑÐ¾ÑÐ³Ð¾Ð²Ð»Ð¸", Ð²ÑÐµÑÐ¾ÑÑÐ¸Ð¹ÑÐºÐ°Ñ Ð½Ð°ÑÑÐ½Ð¾-Ð¿ÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ°Ñ Ð¸ ÑÑÐµÐ±Ð½Ð¾-Ð¼ÐµÑÐ¾Ð´Ð¸ÑÐµÑÐºÐ°Ñ ÐºÐ¾Ð½ÑÐµÑÐµÐ½ÑÐ¸Ñ (2023; Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³)
Publisher: name: ÐÐÐÐÐ¢ÐÐ¥-ÐÐ ÐÐ¡Ð¡
Year: 2023
Subjects: Ð½Ð°ÑÑÐ½ÑÐµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ
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Additional file 4 of IMRT in oral cavity cancer
Creators: name: Studer, Gabriela
name: Zwahlen, Roger A
name: Graetz, Klaus W
name: Davis, Bernard J
name: Glanzmann, Christoph
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Marine Biology
subject: Cancer

description: Authors’ original file for figure 4
Mapping the global chromatin connectivity network for Sox2 function in neural stem cell maintenance
Creators: name: Bertolini, Jessica A
name: Favaro, Rebecca
name: Yanfen Zhu
name: Pagin, Miriam
name: Chew Yee Ngan
name: Wong, Chee Hong
name: Harianto Tjong
name: Vermunt, Marit W
name: Martynoga, Ben
name: Barone, Cristiana
name: Mariani, Jessica
name: Cardozo, Marcos Julián
name: Tabanera, Noemi
name: Zambelli, Federico
name: Mercurio, Sara
name: Ottolenghi, Sergio
name: Robson, Paul
name: Creyghton, Menno P
name: Bovolenta, Paola
name: Pavesi, Giulio
name: Francois Guillemot
name: Nicolis, Silvia K
name: Wei, Chia-Lin
Publisher: name: The Francis Crick Institute
Year: 2019
Subjects: subject: Neurosciences
subject: FOS: Clinical medicine
subject: Model organisms
subject: Gene Expression
subject: Genetics & Genomics
subject: Developmental Biology
subject: Stem Cells

description: The SOX2 transcription factor is critical for neural stem cell (NSC) maintenance and brain development. Through chromatin immunoprecipitation (ChIP) and chromatin interaction analysis (ChIA-PET), we determined genome-wide SOX2-bound regions and Pol II-mediated long-range chromatin interactions in brain-derived NSCs. SOX2-bound DNA was highly enriched in distal chromatin regions interacting with promoters and carrying epigenetic enhancer marks. Sox2 deletion caused widespread reduction of Pol II-mediated long-range interactions and decreased gene expression. Genes showing reduced expression in Sox2-deleted cells were significantly enriched in interactions between promoters and SOX2-bound distal enhancers. Expression of one such gene, Suppressor of Cytokine Signaling 3 (Socs3), rescued the self-renewal defect of Sox2-ablated NSCs. Our work identifies SOX2 as a major regulator of gene expression through connections to the enhancer network in NSCs. Through the definition of such a connectivity network, our study shows the way to the identification of genes and enhancers involved in NSC maintenance and neurodevelopmental disorders.
Elastic constants of stressed and unstressed materials in the phase field crystal model
Creators: name: Wang, Zi-Le
name: Huang, Zhi-Feng
name: Liu, Zhirong
Publisher: name: arXiv
Year: 2017
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: A general procedure to investigate the elastic response and calculate the elastic constants of stressed and unstressed materials through continuum field modeling, particularly the phase field crystal (PFC) models, is presented. It is found that for a complete description of system response to elastic deformation, the variations of all the quantities of lattice wave vectors, their density amplitudes (including the corresponding anisotropic variation and degeneracy breaking), the average atomic density, and system volume should be incorporated. The quantitative and qualitative results of elastic constant calculations highly depend on the physical interpretation of the density field used in the model, and also importantly, on the intrinsic pressure that usually pre-exists in the model system. A formulation based on thermodynamics is constructed to account for the effects caused by constant pre-existing stress during the homogeneous elastic deformation, through the introducing of a generalized Gibbs free energy and an effective finite strain tensor used for determining the elastic constants. The elastic properties of both solid and liquid states can be well produced by this unified approach, as demonstrated by an analysis for the liquid state and numerical evaluations for the bcc solid phase. The numerical calculations of bcc elastic constants and Poisson's ratio through this method generate results that are consistent with experimental conditions, and better match the data of bcc Fe given by molecular dynamics simulations as compared to previous work. The general theory developed here is applicable to the study of different types of stressed or unstressed material systems under elastic deformation.
description: 14 pages, 4 figures. To be published in Phys. Rev. B
Lessons Learned Model Checking an Industrial Communications Library
Creators: name: Ivers, James
Publisher: name: Carnegie Mellon University
Year: 2005
Subjects: subject: 80309 Software Engineering
subject: FOS: Computer and information sciences

description: Model checking is a fully automated formal verification technology that can be used to determine whether models of software satisfy behavioral requirements in such areas as safety, reliability, and security. This report explores the packaging of model checking technology in a reasoning framework. The goal of a reasoning framework is to simplify the analysis of software designs by nonexperts. This report describes the application of such a reasoning framework to the design of an industrial communications library and the problems that were found. This report also notes the tasks that were unreasonably complex or time-consuming and concludes with thoughts on techniques that could be used to develop a model checking reasoning framework that better supports use by nonexperts.
Bootstrapping hypercubic and hypertetrahedral theories in three dimensions
Creators: name: Stergiou, Andreas
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: There are three generalizations of the Platonic solids that exist in all dimensions, namely the hypertetrahedron, the hypercube, and the hyperoctahedron, with the latter two being dual. Conformal field theories with the associated symmetry groups as global symmetries can be argued to exist in $d=3$ spacetime dimensions if the $\varepsilon=4-d$ expansion is valid when $\varepsilon\to1$. In this paper hypercubic and hypertetrahedral theories are studied with the non-perturbative numerical conformal bootstrap. In the $N=3$ cubic case it is found that a bound with a kink is saturated by a solution with properties that cannot be reconciled with the $\varepsilon$ expansion of the cubic theory. Possible implications for cubic magnets and structural phase transitions are discussed. For the hypertetrahedral theory evidence is found that the non-conformal window that is seen with the $\varepsilon$ expansion exists in $d=3$ as well, and a rough estimate of its extent is given.
description: 24 pages, 18 figures. v2: A reference added. v3: A couple of changes. v4: Expanded discussion on structural phase transitions, added some epsilon expansion results. Version to appear in JHEP
title: 01_2804
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Flutter analysis of open-truss stiffened suspension bridges using synthesized aerodynamic derivatives
Creators: name: Al-Assaf, Adel
Publisher: name: Washington State University
Year: 2006
Subjects: Long-span bridges -- Design and construction

description: Aerodynamic analysis is of primary consideration in designing long-span bridges. Theoretical models as well as experimental tools have been developed, which resulted in Wind tunnel tests becoming the fundamental design tool. Recent researches focus on alternative methods to assess the wind response of suspension bridges. These include the computational Fluid Dynamics (CFD) method, which is based on finite element analysis. Theoretically, this method is capable of solving different types of fluid-structure-interaction (FSI) problems. This research discusses the flutter analysis of open-truss stiffened suspension bridges, with an emphasis on the Second Tacoma Narrows Bridge. The scope is to assess the wind response of the bridge using analytical tools. The approach suggested here is to synthesize the wind derivatives based on previous studies of a similar deck configuration. Then the equation of motion and the synthesized aerodynamic forces are solved to find the critical wind speed. In order to conduct an aerodynamic analysis, the frequencies and the mode shapes of the bridge should be determined. Therefore, a frequency analysis is conducted using a detailed finite element model. The results are compared with an ambient study of the bridge, and found to be similar and accurate. The solution procedure and assumptions of the approach are verified using the Golden Gate Bridge flutter analyses, where the experimental aerodynamic coefficients of the bridge are applied in the proposed procedure and compared with the analysis based on the synthesized coefficients. The results of both cases agree with the results in the literature. The analysis procedure is then conducted for the Second Tacoma Narrows Bridge to estimate the critical wind speed is found to be less than the flutter criteria of the bridge.
"All’avvocato bisogna raccontar le cose chiare". Derecho común y juristas en el siglo xvii de Los novios, de Alessandro Manzoni
Creators: name: Landi, Andrea
Publisher: name: Universidad Externado de Colombia
Year: 2023
Subjects: subject: Derecho y literatura
subject: Derecho en la literatura
subject: Abogados
subject: Novios
subject: Derecho común
subject: Abogado
subject: Juez
subject: Justicia

description: El ensayo examine des personajes de Los novios, el doctor Azzecca-garbugliy el podestà de Lecce, que son las figures de juristas que se encuentran en la obra maestra de Alessandro Manzoni; el primero, un causidico intrigante y tramposo, el segundo, un juez propenso a las exigencias del fuerte e insensible a las razenes de la justicia. Se cree que Manzoni, al retratar a estes personajes, no hizo una critica global del mundo forense y judicial, sine que quiso recordar al lector que la Justicia, la verdadera, no puede situarse en una dimensién exclusivamente humana, sine que pertenece a lo trascendente.
description: This essay examines two characters of the Betrothed, Dr. Azzecca-garbugli and the podestà (mayor) of Lecco, who are the figures of jurists who meet in Alessandro Manzoni’s masterpiece; the first, a schemer and swindler casuidist, the second a judge prone to the demands of the strong and insensitive to the reasons of justice. It is believed that Manzoni, in describing these characters, did not carry out an overall criticism of the forensic and judicial world, but wanted to remind the reader that Justice, the true one, cannot be placed in an exclusively human dimension, but belongs to the transcendent.
Exploring the relationship between natural enemy biodiversity and herbivore suppression
Creators: name: Straub, Cory Severen
Publisher: name: Washington State University
Year: 2006
Subjects: Phytophagous insects -- Control

description: Agricultural pest suppression is a valuable ecosystem service that may be enhanced by the conservation of natural enemy species. However, it is unclear how conserving natural enemy diversity per se affects the biological control of pests, because few studies have attempted to distinguish between the effects of enemy abundance, identity, composition, and diversity. In chapter 1, I discuss how an experimental approach traditionally used in plant studies can be adapted to isolate the effects of enemy diversity on the suppression of herbivores. In chapter 2, I apply this experimental approach to examine how increasing enemy diversity within the potato agroecosystem affects the biological control of the green peach aphid, Myzus persicae. In this study, I find that increasing enemy diversity has no overall effect on the strength of aphid suppression. In chapter 3, I focus on a different assemblage of enemy species, one in which interference may be particularly likely, and examine how both the diversity and composition of the enemy community affect the strength of biological control. I find that increasing enemy diversity can strengthen, weaken, or not affect the suppression of herbivores, depending on the particular composition of enemy species that coexist in the community. In chapter 4 I test the hypothesis that multi-enemy effects on prey suppression may also vary with the identity of the plant species upon which the higher trophic levels interact. Here I focus on a single composition of enemy species that occurs in both potato and collard agroecosystems. I find that increasing diversity within this enemy assemblage leads to stronger aphid suppression on both plant species. However, because aphids reproduced at a much higher rate on collards than on potatoes, increasing enemy diversity reduced aphid populations by ~ 200 aphids per plant on collards but only by ~ 6 aphids per plant on potatoes. This indicates that the value of conserving enemy diversity will be far greater on collards than on potatoes. Taken together, this body research shows that a general relationship between enemy diversity and biological control may not exist, and that the value of conserving enemy diversity per se will likely vary among agroecosystems.
Kanye West’s Postmodern Anxiety: Who Takes the Rap?
Creators: name: Fletcher, Marcelle-Anne
Publisher: name: My University
Year: 2017
Subjects: Black masculinity
Oedipus complex
performativity
patriarchy
rap lyricism

description: This paper will examine the representations of Black masculinity in the lyrics of poetry. Rap music, like other works of poetry, can be analyzed within multidisciplinary frameworks. Specifically, this scholarly work will conduct a comparative analysis of Kanye West’s rap songs entitled “Hey Mama” and “Mama’s Boyfriend” to illustrate the ways in which recorded music is subject to the disciplinary production of hegemonic masculinity that is both patriarchal and heteronormative. A feminist, literary and psychoanalytic interpretation of this poetry reveal how lyrical language, artistic experience, and musical genre function to produce thematic suggestions of the Oedipus complex.