cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Healing of rectal advancement flaps for anal fistulas in patients with and without Crohn’s disease: a retrospective cohort analysis
Creators: name: Seifarth, Claudia
name: Lehmann, Kai S.
name: Holmer, Christoph
name: Pozios, Ioannis
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Anal fistula
subject: Rectal advancement flap
subject: Crohn's disease
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Surgical closure of anal fistulas with rectal advancement flaps is an established standard method, but it has a high degree of healing failure in some cases. The aim of this study was to identify risk factors for anal fistula healing failure after advancement flap placement between patients with cryptoglandular fistulas and patients with Crohn's disease (CD). Methods: From January 2010 to October 2020, 155 rectal advancement flaps (CD patients = 55, non-CD patients = 100) were performed. Patients were entered into a prospective database, and healing rates were retrospectively analysed. Results: The median follow-up period was 189 days (95% CI: 109-269). The overall complication rate was 5.8%. The total healing rate for all rectal advancement flaps was 56%. CD patients were younger (33 vs. 43 years, p < 0.001), more often female (76% vs. 30%, p < 0.001), were administered more immunosuppressant medication (65% vs. 5%, p < 0.001), and had more rectovaginal fistulas (29% vs. 8%, p = 0.001) and more protective stomas (49% vs. 2%, p < 0.001) than patients without CD. However, no difference in healing rate was noted between patients with or without CD (47% vs. 60%, p = 0.088). Conclusions: Patients with anal fistulas with and without Crohn's disease exhibit the same healing rate. Although patients with CD display different patient-specific characteristics, no independent factors for the occurrence of anal fistula healing failure could be determined. Trial registration Not applicable due to the retrospective study design.
A Note on the Minimum Number of Edges in Hypergraphs with Property O
Creators: name: Kronenberg, Gal
name: Kusch, Christopher
name: Lamaison, Ander
name: Micek, Piotr
name: Tran, Tuan
Publisher: name: arXiv
Year: 2017
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: An oriented $k$-uniform hypergraph is said to have Property O if for every linear order of the vertex set, there is some edge oriented consistently with the linear order. Recently Duffus, Kay and Rödl investigated the minimum number $f(k)$ of edges in a $k$-uniform hypergaph with Property O. They proved that $k! \leq f(k) \leq (k^2 \ln k) k!$, where the upper bound holds for $k$ sufficiently large. In this short note we improve their upper bound by a factor of $k \ln k$, showing that $f(k) \le \left(\lfloor \frac{k}{2} \rfloor +1 \right) k! - \lfloor \frac{k}{2} \rfloor (k-1)!$ for every $k\geq 3$. We also show that their lower bound is not tight. Furthermore, Duffus, Kay and Rödl also studied the minimum number $n(k)$ of vertices in a $k$-uniform hypergaph with Property O. For $k=3$ they showed $n(3) \in \{6,7,8,9\}$, and asked for the precise value of $n(3)$. Here we show $n(3)=6$.
description: 6 pages, 1 figure
Determinants of overall knowledge and health behaviours in relation to hepatitis B and C among ever-married women in Pakistan: evidence based on Demographic and Health Survey 2017–18
Creators: name: Maqsood, Sidra
name: Iqbal, Sarosh
name: Zakar, Rubeena
name: Zakar, Muhammad Zakria
name: Fischer, Florian
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: HBV
subject: HCV
subject: Knowledge
subject: Attitude
subject: Practice
subject: Social determinants
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: In 2019, around 5 million and 10 million people were affected by hepatitis B virus (HBV) and hepatitis C virus (HCV) respectively in Pakistan. On World Hepatitis Day 2019, Pakistan's Government announced the Prime Minister's Plan to eliminate HBV and HCV from the country by 2030. In order to achieve this goal, adequate knowledge about HBV and HCV regarding mode of transmission, symptoms of the disease, and awareness about available treatments and vaccines is imperative. The present study aims to investigate the determinants related to overall knowledge about and behaviour in relation to HBV and HCV amongst married women in Pakistan. Methods: Secondary data analysis was carried out using the Pakistan Demographic and Health Survey (PDHS) 2017-18. A series of questions regarding women's knowledge about how to avoid HBV and HCV and their health behaviour in relation to HBV and HCV were posed to 12,364 ever-married women of reproductive age (15-49 years). Bivariate and multivariable logistic and linear regression was applied to examine the effects of sociodemographic characteristics and covariates on women's overall knowledge and health behaviour regarding HBV and HCV. Results: The findings highlight that the majority of women (88.3%) have heard of HBV and HCV. Nonetheless, only 34.8% had comprehensive knowledge about how to avoid HBV and HCV. Few women (11.3%) had been tested for HBV or HCV during the year preceding the survey. Furthermore, the results indicate that women living in urban areas, being older, and having more than 10 years of schooling, reported better knowledge and health behaviours regarding HBV and HCV. Conclusion: This study provides evidence that women's sociodemographic characteristics create differences in their overall knowledge about and attitudes towards HBV and HCV. This research emphasized that there is a need to create awareness about the causes and prevention of HBV and HCV in order to achieve the goal of eliminating these diseases in Pakistan by 2030.
Metadata Schema for the German Human Genome-Phenome Archive
Creators: name: Iyappan, Anandhi
name: Mauer, Karoline
name: Menges, Paul
name: Sürün, Bilge
name: Tremper, Galina
name: Parker, Simon
name: Kırlı, Koray
name: Kraus, Florian
name: Unni, Deepak
name: Schultze, Joachim L.
name: Bork, Peer
name: Ulas, Thomas
name: Nahnsen, Sven
name: Consortium, The GHGA
Publisher: name: Zenodo
Year: 2023
Subjects: Metadata
FAIR
Data sharing
Ontology
Standards
Guidelines
Genomic data
LinkML

description: This White Paper summarizes the development of the German Human Genome-Phenome Archive (GHGA) Metadata Model and describes the modeling framework in detail. Further, it elaborates on implemented ontologies, data privacy considerations and alignment with other (inter-) national consortia.
description: This project was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) as part of GHGA – The German Human Genome-Phenome Archive (www.ghga.de, Grant Number 441914366 (NFDI 1/1))
Inns and Inn Signs of Leicestershire and Rutland
Creators: name: Swift, Eric
Publisher: name: Archaeology Data Service
Year: 2023

description: Transactions of the Leicestershire Archaeological and Historical Society, 41, 57-64
description: There is a wide range and much variety in our local inn names and sign boards through the counties of Leicestershire and Rutland are not specially rich in quaint or comic or bizarre signs. The inn is as old as travel itself, and the traveller had to have somewhere to refresh himself and somewhere to sleep at night and stable his mount. Cars unlike horses can be left outside and unattended. Where houses were small there had to be places where a man could meet his fellows away from the restrictions of home. The inns and taverns where he did this have left their symbols for our wonder and delight, a pleasure to the social historian and a joy still to the man who seeks refreshment and rest.
What do Germans really think about health-nudges?
Creators: name: Krisam, Mathias
name: Maier, Mona
name: Janßen, Rebecca
name: Krisam, Johannes
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Nudges
subject: Germans
subject: Acceptance
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: In recent years, policymakers have increasingly used behaviourally informed policies, including 'nudges'. They have been implemented to produce desirable social outcomes such as healthier eating and physical activity. In Germany, a small research team at the Federal Chancellery acts as the central unit to promote the introduction of nudges in the design of public life. Despite this, the nudging concept itself as well as the understanding around it has not spread widely among German citizens. When reporting about the concept, German media is often very critical of the concept. Methods: Using a for age, sex and educational level nationally representative online survey with 1000 participants, we investigate whether German citizens know about the concept of nudging. We also explore if they approve of the theoretical concept as well as a list of seven specific interventions regarding healthy eating and physical activity. A particular focus is placed on whether the level of approval is dependent on the target group of the intervention, as well as different intervention-initiators. Results: We find that nearly 80% of the respondents have never heard of nudging. However when being provided with a definition, we find that a strong majority (90%) supports the concept of nudging as well as all the specific interventions. Acceptance rates are higher if interventions are targeted at the general population compared to only children. All initiators - statutory health insurers, the government, private companies, and independent experts are accepted as nudge initiators. Conclusion: Amongst Germans nudges are an accepted method to promote health behaviours. Policy makers from various fields in Germany should take that into account to improve future health policy.
(502386) Horatio Bladen Capell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The brooches of the Noel Spurway collection: Glimpses into antique and antiquarian Leicester
Creators: name: Szafara, Victoria
Publisher: name: Archaeology Data Service
Year: 2022

description: Transactions of the Leicestershire Archaeological and Historical Society, 93, 49-78
description: A collection of 67 brooches, dated stylistically to the late pre-Roman Iron Age and Roman periods, exists as part of the Leicester Arts and Museums Service holdings. This research provides new typological identification for each, as well as contextual analyses regarding their deposition in antiquity and excavation in the Victorian period. Once part of the private collection of the early twentieth century business magnate Noel Spurway, these artefacts convey information not only regarding Leicester's Roman occupation, but also the nature of building and development at the time of their rediscovery. This paper probes the typologies and geographical find spots of these brooches in order to trace patterns of settlement in the city over time.
Predictors of parental mediation in teenagers’ internet use: a cross-sectional study of female caregivers in Lahore, Pakistan
Creators: name: Iqbal, Sarosh
name: Zakar, Rubeena
name: Fischer, Florian
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Teen
subject: Children
subject: Online
subject: Internet addiction
subject: Risk
subject: Resilience
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: The internet has become the most widely used medium among teenagers, who spend much of their time online, which raises parental concerns. Notwithstanding teens' increased internet use and exposure to online risks, little is yet known about parental internet mediation in local settings. The present research aimed to assess the various dimensions of parental mediation to regulate teens' use of the internet and their predictors. Methods: A cross-sectional survey was conducted in the district of Lahore, Pakistan, among mothers/female caregivers of teens (aged 13-19 years). Only women were interviewed because they are more frequently engaged as primary caregivers than fathers or male caregivers. Furthermore, only qualified and working mothers from the top two professions among women, i.e. academia and medicine, were interviewed. A stratified random sampling technique was adopted, and 347 mothers were interviewed using face-to-face interviews at 11 universities and 11 hospitals/medical colleges. Data were entered and analysed using descriptive, bivariate and multivariate logistic regression analyses. Results: The findings highlighted that more than 65% of respondents applied highly active mediation of internet safety, around 60% used highly active co-use mediation and more than 56% applied restrictive mediation. In addition, 36% of respondents monitored and 15.3% technically mediated to regulate their teens' use of the internet. The results of the multivariate logistic regression revealed that the majority of respondents were more inclined to adopt active internet safety mediation if they had teens aged 16-19 years, with medium internet addiction, possessed good digital skills, felt confident about their teens' coping appraisal to perform online protection, and considered their teens to have high self-esteem and resilience. Conclusions: This research found that parental internet mediation is a multifaceted concept used to regulate teens' online activity and enhance a resilient approach to reduce the risks associated with use of the internet. The researchers recommend developing parental guidelines, e-safety resource material, local support networks and community programmes to educate parents, teachers and teens in order to raise awareness and promote resilient pathways amongst teens.
JETIR2107426 (2).pdf
Creators: name: Gond, Abhishek
name: Vashishtha, Er.Jitendra
name: Pratap Singh, Virendra
name: Shekhar, Chandra
name: Kumar, Gaurav
name: Kumar, Pawan
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 400806
subject: Electrical machines and drives

description: The main aim of this project is to control the motion and speed control of stepper motor with an arduino board. This is a new technology to control direction and speed control of stepper motor. We control the motor manually which may cause manual errors. It becomes very difficult for the elderly or physically handicapped people to operate them. This system is enhanced to control the stepper motor through an arduino board by dumping corresponding program. The proposed systems uses an arduino board.
An extension of Bonnet-Myers theorem
Creators: name: Wan, Jianming
Publisher: name: arXiv
Year: 2017
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics

description: We give a complementary generalization of the extensions of Bonnet-Myers theorem obtained by Calabi and also Cheeger-Gromov-Taylor.
The Due Tenth: Problems of the Leicestershire Tithing Process 1560-1640
Creators: name: Tarver, Anne
Publisher: name: Archaeology Data Service
Year: 2022

description: Transactions of the Leicestershire Archaeological and Historical Society, 78, 97-107
description: This article explores the processes of the tithing system in early modern Leicestershire, considering both the rules of tithing and contemporary farming practices. Analysis of 480 tithe disputes shows their comparative rarity in the county, being used for arbitration rather than adversarial cases. Differences between disputes in the northern and southern provinces would appear to be considerable, with a high proportion of small tithes cases dominating the Leicester court compared with those for great tithes in the York courts. Even within the southern province local differences appear with a great number of cases passing through the sixteenth-century courts of Oxford, Worcester, and Gloucester. The Leicester cases appear to have been influenced by William Laud and John Lambe, Arminians, and show a predominance of small tithe cases brought by vicars.
Reverend Manton and the Tithes of Houghton on the Hill
Creators: name: Tarver, Anne
Publisher: name: Archaeology Data Service
Year: 2022

description: Transactions of the Leicestershire Archaeological and Historical Society, 79, 103-106
description: The account of tithing at Houghton on the Hill in the eighteenth century illustrates the problems of a cleric of this period immediately after his induction to a parish. Robert Manton was the son of Nathaniel Manton of the City of London, a knight who was educated at Oxford. He gained his BA in 1668 at the age of 20 and then went on to become rector of Withcote in 1677, where he would have been able to claim the great and small tithes of this small parish. This sparsely populated parish in the east of the county was not one from which a good living was to be made. Manton's fortune changed 29 years later in 1706 when he was inducted to the rectory of Houghton on the Hill, a larger and potentially more productive parish, five miles east of Leicester. When a new incumbent was inducted to a living he had no information about the tithing customs of the parish or the names of his new parishioners. As Manton himself said, 'I heare not of any Easter Roll'. He had to find this out from a parish that was not always friendly and with some people still grieving for the previous incumbent. The parish customs and practices of tithing continued into the nineteenth century in those parishes that had not been enclosed.
Entanglement renormalization for chiral topological phases
Creators: name: Li, Zhi
name: Mong, Roger S. K.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We considered the question of applying the multiscale entanglement renormalization ansatz (MERA) to describe chiral topological phases. We defined a functional for each layer in the MERA, which captures the correlation length. With some algebraic geometry tools, we rigorously proved its monotonicity with respect to adjacent layers, and the existence of a lower bound for chiral states, which shows a trade-off between the bond dimension and the correlation length. Using this theorem, we showed the number of orbitals per cell (which roughly corresponds to the bond dimension) should grow with the height. Conversely, if we restrict the bond dimensions to be constant, then there is an upper bound of the height. Specifically, we established a no-go theorem stating that we will not approach a renormalization fixed point in this case.
description: 9 pages, 3 figures
(502385) Mary Kathleen Capell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The effect of age on short-term and mid-term outcomes after thoracoscopic Ivor Lewis esophagectomy: a propensity score-matched analysis
Creators: name: Martin, Friederike
name: Kröll, Dino
name: Knitter, Sebastian
name: Hofmann, Tobias
name: Raakow, Jonas
name: Denecke, Christian
name: Pratschke, Johann
name: Biebl, Matthias
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Outcome
subject: Age
subject: Thoracoscopic esophagectomy
subject: Ivor Lewis
subject: Esophageal cancer
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: The number of elderly patients diagnosed with esophageal cancer rises. Current information about outcomes in elderly patients undergoing thoracoscopic Ivor Lewis esophagectomy is limited. The objective of this study was to evaluate the influence of age on short-and mid-term outcomes after thoracoscopic Ivor Lewis esophagectomy. Methods: A retrospective review of 188 patients with esophageal cancer undergoing thoracoscopic Ivor Lewis esophagectomy between August 2014 and July 2019 was performed. Patients were divided into patients aged > 75 years (elderly group (EG), n = 37) and patients <= 75 years (younger group (YG), n = 151) and matched using propensity-score matching. Baseline characteristics, length of hospital stay, mortality and major postoperative complications (Clavien-Dindo >= grade III) were compared. Results: After matching 74 patients remained (n = 37 in each group). Postoperatively, no significant differences in major and overall complications, intra-hospital and 30-day mortality, disease-free or overall survival up to 3 years after surgery were noted. The incidence of pulmonary complications (65% vs. 38%) and pneumonia (54% vs. 30%) was significantly higher and the median hospital length of stay (12 vs. 14 days) significantly longer in the EG versus YG. Conclusion: Thoracoscopic Ivor Lewis esophagectomies resulted in acceptable postoperative major morbidity and mortality without compromising 3-years overall and disease-free survival in elderly compared to younger patients with esophageal cancer. However, the incidence of postoperative pulmonary complications was higher in patients aged over 75 years.
Marriage, Morals and Money
Creators: name: Tarver, Anne
Publisher: name: Archaeology Data Service
Year: 2022

description: Transactions of the Leicestershire Archaeological and Historical Society, 82, 189-204
description: This paper examines the case of a rare and scandalous marital breakdown heard in the Lichfield Consistory Court between May and November 1716, following a hasty marriage conducted without parental approval. Other papers relating to Chancery cases and family research in the nineteenth century have been examined which show the financial, legal and psychological effects of this disastrous marriage upon the family members and their fortunes through the century.
Epigenetic adaptations of the masticatory mucosa to periodontal inflammation
Creators: name: Richter, Gesa M.
name: Kruppa, Jochen
name: Keceli, H. Gencay
name: Ataman-Duruel, Emel Tuğba
name: Graetz, Christian
name: Pischon, Nicole
name: Wagner, Gunar
name: Rendenbach, Carsten
name: Jockel-Schneider, Yvonne
name: Martins, Orlando
name: Bruckmann, Corinna
name: Staufenbiel, Ingmar
name: Franke, Andre
name: Nohutcu, Rahime M.
name: Jepsen, Søren
name: Dommisch, Henrik
name: Schaefer, Arne S.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: EWAS
subject: Methylation
subject: Periodontitis
subject: Gingiva
subject: Inflammation
subject: Cell type deconvolution
subject: ROBO2
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: In mucosal barrier interfaces, flexible responses of gene expression to long-term environmental changes allow adaptation and fine-tuning for the balance of host defense and uncontrolled not-resolving inflammation. Epigenetic modifications of the chromatin confer plasticity to the genetic information and give insight into how tissues use the genetic information to adapt to environmental factors. The oral mucosa is particularly exposed to environmental stressors such as a variable microbiota. Likewise, persistent oral inflammation is the most important intrinsic risk factor for the oral inflammatory disease periodontitis and has strong potential to alter DNA-methylation patterns. The aim of the current study was to identify epigenetic changes of the oral masticatory mucosa in response to long-term inflammation that resulted in periodontitis. Methods and results: Genome-wide CpG methylation of both inflamed and clinically uninflamed solid gingival tissue biopsies of 60 periodontitis cases was analyzed using the Infinium MethylationEPIC BeadChip. We validated and performed cell-type deconvolution for infiltrated immune cells using the EpiDish algorithm. Effect sizes of DMPs in gingival epithelial and fibroblast cells were estimated and adjusted for confounding factors using our recently developed "intercept-method". In the current EWAS, we identified various genes that showed significantly different methylation between periodontitis-inflamed and uninflamed oral mucosa in periodontitis patients. The strongest differences were observed for genes with roles in wound healing (ROBO2, PTP4A3), cell adhesion (LPXN) and innate immune response (CCL26, DNAJC1, BPI). Enrichment analyses implied a role of epigenetic changes for vesicle trafficking gene sets. Conclusions: Our results imply specific adaptations of the oral mucosa to a persistent inflammatory environment that involve wound repair, barrier integrity, and innate immune defense.
Effect of anisotropy distribution on local nucleation field in bistable ferromagntic microwires
Creators: name: Kwiatkowski, Grzegorz
Publisher: name: arXiv
Year: 2017
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Critical parameters defining the local nucleation field in amorphous ferromagnetic microwires with positive magnetostriction are obtained analytically through scaling procedures. Exact value of the nucleation field is obtained numerically as a function of geometric parameters of anisotropy distribution, which is fully taken into account instead of being averaged out. It is established that the value of nucleation field depends predominantly on the steepness of anisotropy change withing the boundary between axial and radial domains, while the maximal value of anisotropy inside the wire or an overall average is not relevant.
description: 12 pages, 4 figures
人体活动识别ACC心电图、
Creators: name: yanling, Ren
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 400309
subject: Neural engineering

description: 在数字医学中，人类活动识别（HAR）可用于跟踪和评估患者在整个康复过程中的进展，从而提高老年人和残疾人的生活质量。
Macrophage activation syndrome in a patient with adult-onset Still’s disease following first COVID-19 vaccination with BNT162b2
Creators: name: Muench, Frédéric
name: Krusche, Martin
name: Sander, Leif Erik
name: Rose, Thomas
name: Burmester, Gerd-Rüdiger
name: Schneider, Udo
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Adult-onset Still's disease
subject: Macrophage activation syndrome
subject: Vaccine reaction
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Adult-onset Still's disease (AOSD) is an autoinflammatory multi-systemic syndrome. Macrophage activation syndrome (MAS) is a potentially life-threatening complication of AOSD with a mortality rate of 10-20%. Especially viral infection is thought to be a common trigger for development of MAS. On the other hand, the occurrence of MAS following vaccinations is extremely rare and has been described in a few cases after measles or influenza vaccinations and more recently after ChAdOx1 nCoV-19 (COVID-19 viral vector vaccine, Oxford-AZ). Case presentation: We report the case of a twenty-year-old female with adult-onset Still's disease (AOSD), who developed a MAS six days after receiving her first COVID-19 vaccine dose of BNT162b2 (mRNA vaccine, BioNTech/Pfizer) with ferritin levels of 136,680 mu g/l (ref.: 13-150 mu g/l). Conclusions: To the best of our knowledge, this is the first case report of development of MAS in a patient with preexisting AOSD after vaccination in general, and SARS-CoV-2 vaccination in particular. The new mRNA vaccines have generally shown a reassuring safety profile, but it has been shown that nucleic acids in general, including mRNA can act as pathogen-associated molecular patterns that activate toll-like receptors with extensive production of pro-inflammatory cytokines and further activation of immune cells. Proving an interferon 1 response in our patient directly after vaccination, we think that in this particular case the vaccination might have acted as trigger for the development of MAS. Even if it remains difficult to establish causality in the case of rare adverse events, especially in patients with autoimmune or autoinflammatory conditions, these complications are important to monitor and register, but do not at all diminish the overwhelming positive benefit-risk ratio of licensed COVID-19 vaccines.
The Making of the Leicestershire Canals, 1766-1814
Creators: name: Temple Patterson, Alfred
Publisher: name: Archaeology Data Service
Year: 2023

description: Transactions of the Leicestershire Archaeological and Historical Society, 27, 66-99
description: Until the middle of the eighteenth century, the situation of Leicestershire (much of which bestrides the central watershed of England) was an appreciable handicap to economic development in an age when water-carriage played a very large-almost a dominant-part in the means of transportation. "Had it a navigable river", wrote Burton of the town of Leicester in 1622, "whereby it might have trading and commerce, it might compare with many of no mean rank". The trading and the commerce did indeed grow with the coming of the hosiery industry a little later, but the handicap remained. By 1750, the whole of eastern England between the Humber and the Thames was well served with waterways which were navigable, or had been made so; and the western Midlands were similarly provided for by the Severn and Mersey and their affiuents. But in the centre of the country there was a large area which had no navigable water-ways at all; and of this area Leicestershire constituted a considerable part.
(502384) George West
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Symmetric Gapped Interfaces of SPT and SET States: Systematic Constructions
Creators: name: Wang, Juven
name: Wen, Xiao-Gang
name: Witten, Edward
Publisher: name: arXiv
Year: 2017
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Theory (hep-th)
subject: Algebraic Topology (math.AT)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: Symmetry protected topological (SPT) states have boundary 't Hooft anomalies that obstruct an effective boundary theory realized in its own dimension with UV completion and an on-site $G$-symmetry. In this work, yet we show that a certain anomalous non-on-site $G$ symmetry along the boundary becomes on-site when viewed as an extended $H$ symmetry, via a suitable group extension $1\to K\to H\to G\to1$. Namely, a non-perturbative global (gauge/gravitational) anomaly in $G$ becomes anomaly-free in $H$. This guides us to construct exactly soluble lattice path integral and Hamiltonian of symmetric gapped boundaries, always existent for any SPT state in any spacetime dimension $d \geq 2$ of any finite symmetry group, including on-site unitary and anti-unitary time-reversal symmetries. The resulting symmetric gapped boundary can be described either by an $H$-symmetry extended boundary of bulk $d \geq 2$, or more naturally by a topological emergent $K$-gauge theory with a global symmetry $G$ on a 3+1D bulk or above. The excitations on such a symmetric topologically ordered boundary can carry fractional quantum numbers of the symmetry $G$, described by representations of $H$. (Apply our approach to a 1+1D boundary of 2+1D bulk, we find that a deconfined gauge boundary indeed has spontaneous symmetry breaking with long-range order. The deconfined symmetry-breaking phase crosses over smoothly to a confined phase without a phase transition.) In contrast to known gapped interfaces obtained via symmetry breaking (either global symmetry breaking or Anderson-Higgs mechanism for gauge theory), our approach is based on symmetry extension. More generally, applying our approach to SPT, topologically ordered gauge theories and symmetry enriched topologically ordered (SET) states, leads to generic boundaries/interfaces constructed with a mixture of symmetry breaking, symmetry extension, and dynamical gauging.
description: 144 pages, 29 figures, 22 tables. v3: Refinement/Refs added. Un/Trimmed version on arXiv/PRX
A Fifteenth Century Leicestershire Lawyer and Parliamentary Knight of the Shire
Creators: name: Thomas Driver, John
Publisher: name: Archaeology Data Service
Year: 2023

description: Transactions of the Leicestershire Archaeological and Historical Society, 69, 42-58
description: The career of Thomas Palmer typified that of a fifteenth-century gentleman of modest estate who, through service. on commissions, formed the backbone of the county community. A lawyer and long-serving Justice of the Peace, he had political associations with the Hastings family and even with Richard, Duke of York, and King Edward IV. Palmer was elected to the Commons six times for Leicestershire and once for Rutland.
Estimands in epigenome-wide association studies
Creators: name: Kruppa, Jochen
name: Sieg, Miriam
name: Richter, Gesa
name: Pohrt, Anne
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: DNA methylation
subject: Epigenome-wide association study (EWAS)
subject: Estimands
subject: Multiple testing
subject: Reproducible research
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: In DNA methylation analyses like epigenome-wide association studies, effects in differentially methylated CpG sites are assessed. Two kinds of outcomes can be used for statistical analysis: Beta-values and M-values. M-values follow a normal distribution and help to detect differentially methylated CpG sites. As biological effect measures, differences of M-values are more or less meaningless. Beta-values are of more interest since they can be interpreted directly as differences in percentage of DNA methylation at a given CpG site, but they have poor statistical properties. Different frameworks are proposed for reporting estimands in DNA methylation analysis, relying on Beta-values, M-values, or both. Results: We present and discuss four possible approaches of achieving estimands in DNA methylation analysis. In addition, we present the usage of M-values or Beta-values in the context of bioinformatical pipelines, which often demand a predefined outcome. We show the dependencies between the differences in M-values to differences in Beta-values in two data simulations: a analysis with and without confounder effect. Without present confounder effects, M-values can be used for the statistical analysis and Beta-values statistics for the reporting. If confounder effects exist, we demonstrate the deviations and correct the effects by the intercept method. Finally, we demonstrate the theoretical problem on two large human genome-wide DNA methylation datasets to verify the results. Conclusions: The usage of M-values in the analysis of DNA methylation data will produce effect estimates, which cannot be biologically interpreted. The parallel usage of Beta-value statistics ignores possible confounder effects and can therefore not be recommended. Hence, if the differences in Beta-values are the focus of the study, the intercept method is recommendable. Hyper- or hypomethylated CpG sites must then be carefully evaluated. If an exploratory analysis of possible CpG sites is the aim of the study, M-values can be used for inference.
人体活动识别、ACC心电图、
Creators: name: yanling, Ren
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 400309
subject: Neural engineering

description: 在数字医学中，人类活动识别（HAR）可用于跟踪和评估患者在整个康复过程中的进展，从而提高老年人和残疾人的生活质量。
(502383) Catherine Helena West
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Three Bronze Age Round Barrows at Cossington: A History of Use and Re-use
Creators: name: Thomas, John A
Publisher: name: Archaeology Data Service
Year: 2022

description: Transactions of the Leicestershire Archaeological and Historical Society, 81, 35-63
description: Archaeological work during gravel quarrying at Cossington, Leicestershire, has included the excavation of three Bronze Age round barrows (two excavated in 1976 and the third in 1999) that are part of a dispersed barrow cemetery, located at the confluence of the Rivers Soar and Wreake. Environmental information has enabled a picture of the Cossington landscape in which the barrows were constructed to be pieced together. Together the three excavations provide important information on the variety of monumental architecture and burial traditions that were employed in the Bronze Age. The remarkable preservation of the barrow excavated in 1999 has also revealed the extent to which such monuments were reused over time. This barrow formed the focus for later activities in the Iron Age, Romano-British and Anglo-Saxon periods, when the mound became the setting for a small inhumation cemetery. An area to the east of this barrow revealed a rich palimpsest of ditches, gullies and a post alignment reflecting a complex history of land division in the vicinity of the monument.
Classical causal models for Bell and Kochen-Specker inequality violations require fine-tuning
Creators: name: Cavalcanti, Eric G.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Nonlocality and contextuality are at the root of conceptual puzzles in quantum mechanics, and are key resources for quantum advantage in information-processing tasks. Bell nonlocality is best understood as the incompatibility between quantum correlations and the classical theory of causality, applied to relativistic causal structure. Contextuality, on the other hand, is on a more controversial foundation. In this work, I provide a common conceptual ground between nonlocality and contextuality as violations of classical causality. First, I show that Bell inequalities can be derived solely from the assumptions of no-signalling and no-fine-tuning of the causal model. This removes two extra assumptions from a recent result from Wood and Spekkens, and remarkably, does not require any assumption related to independence of measurement settings -- unlike all other derivations of Bell inequalities. I then introduce a formalism to represent contextuality scenarios within causal models and show that all classical causal models for violations of a Kochen-Specker inequality require fine-tuning. Thus the quantum violation of classical causality goes beyond the case of space-like separated systems, and manifests already in scenarios involving single systems.
description: 9 pages, 14 figures. Modified title, discussion and presentation
Psychosocial stress increases testosterone in patients with borderline personality disorder, post-traumatic stress disorder and healthy participants
Creators: name: Deuter, Christian E.
name: Duesenberg, Moritz
name: Hellmann-Regen, Julian
name: Metz, Sophie
name: Roepke, Stefan
name: Wolf, Oliver T.
name: Otte, Christian
name: Wingenfeld, Katja
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Borderline personality disorder
subject: Post-traumatic stress disorder
subject: Testosterone
subject: Stress response
subject: Psychosocial stress
subject: Trier social stress test
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: The gonadal hormone testosterone not only regulates sexual behavior but is also involved in social behavior and cognition in both sexes. Changes in testosterone secretion in response to stress have been reported. In addition, stress associated mental disorders such as borderline personality disorder (BPD) and posttraumatic stress disorder (PTSD) are characterized by alterations in basal testosterone metabolism. However, testosterone changes to stress have not been investigated in mental disorders such as BPD and PTSD so far. Methods: In the study described, we investigated testosterone reactivity to an acute psychosocial stressor, the Trier Social Stress Test (TSST). Our sample consisted of young adult women with BPD (n = 28), PTSD (n = 22) or both disorders (n = 22), and healthy control (n = 51). Based on previous studies on basal testosterone secretion in these disorders, we expected the stress-associated testosterone reactivity to be higher in the BPD group and lower in the PTSD group, when compared to the healthy control group. Results: The study could demonstrate an increase in testosterone after acute stress exposure across all groups and independent of BPD or PTSD status. Different possible explanations for the absence of a group effect are discussed. Conclusions: From the results of this study, we conclude that stress-related changes in testosterone release are not affected by BPD or PTSD status in a female patient population. This study expands the knowledge about changes in gonadal hormones and stress reactivity in these disorders.
Robotic-assisted pancreatic surgery in the elderly patient: experiences from a high-volume centre
Creators: name: Hillebrandt, Karl H.
name: Knitter, Sebastian
name: Timmermann, Lea
name: Felsenstein, Matthäus
name: Benzing, Christian
name: Schmelzle, Moritz
name: Pratschke, Johann
name: Malinka, Thomas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Robotic-assisted pancreatic surgery
subject: Pancreatic surgery
subject: Elderly patients
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Robotic-assisted pancreatic surgery (RPS) has fundamentally developed over the past few years. For subgroups, e.g. elderly patients, applicability and safety of RPS still needs to be defined. Given prognosticated demographic developments, we aim to assess the role of RPS based on preoperative, operative and postoperative parameters. Methods: We included 129 patients undergoing RPS at our institution between 2017 and 2020. Eleven patients required conversion to open surgery and were excluded from further analysis. We divided patients into two groups; >= 70 years old (Group 1; n = 32) and < 70 years old (Group 2; n = 86) at time of resection. Results: Most preoperative characteristics were similar in both groups. However, number of patients with previous abdominal surgery was significantly higher in patients >= 70 years old (78% vs 37%, p < 0.0001). Operative characteristics did not significantly differ between both groups. Although patients >= 70 years old stayed significantly longer at ICU (1.8 vs 0.9 days; p = 0.037), length of hospital stay and postoperative morbidity were equivalent between the groups. Conclusion: RPS is safe and feasible in elderly patients and shows non-inferiority when compared with younger patients. However, prospectively collected data is needed to define the role of RPS in elderly patients accurately. Trial registration Clinical Trial Register: Deutschen Register Klinischer Studien (DRKS; German Clinical Trials Register). Clinical Registration Number: DRKS00017229 (retrospectively registered, Date of Registration: 2019/07/19, Date of First Enrollment: 2017/10/18).
Excavation of a Medieval Post-mill Mound at Manor Farm, Humberstone, Leicester
Creators: name: Thomas, John A
Publisher: name: Archaeology Data Service
Year: 2022

description: Transactions of the Leicestershire Archaeological and Historical Society, 83, 113-129
description: Archaeological recording of a medieval windmill mound at Manor Farm, Humberstone, Leicester was undertaken in 2007 by University of Leicester Archaeological Services (ULAS) in advance of development by Gateway College. Excavation revealed the mound to consist of two deposits of clay, each associated with a phase of the mound's development. A recut ditch encircled the mound and originally acted as a quarry for the mound soils. Well-preserved timber cross-tree foundations survived in situ beneath the mound, within a construction slot cut into the natural clay. Pottery recovered from the construction slot and primary fills of each ditch cut indicated a twelfth-thirteenth century period of use for the mill. Later pottery in the final ditch fills suggest the mill had fallen into disuse by the seventeenth-eighteenth century.
Euler Characteristics of Crepant Resolutions of Weierstrass Models
Creators: name: Esole, Mboyo
name: Jefferson, Patrick
name: Kang, Monica Jinwoo
Publisher: name: arXiv
Year: 2017
Subjects: subject: Algebraic Geometry (math.AG)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: Based on an identity of Jacobi, we prove a simple formula that computes the pushforward of analytic functions of the exceptional divisor of a blowup of a projective variety along a smooth complete intersection with normal crossing. We apply this pushforward formula to derive generating functions for Euler characteristics of crepant resolutions of singular Weierstrass models given by Tate's algorithm. Since these Euler characteristics depend only on the sequence of blowups and not on the Kodaira fiber itself, nor the associated group, several distinct Tate models have the same Euler characteristic. In the case of elliptic Calabi-Yau threefolds, we also compute the Hodge numbers. For elliptically fibered Calabi-Yau fourfolds, our results also prove a conjecture of Blumenhagen-Grimm-Jurke-Weigand based on F-theory/heterotic string duality.
description: v4:Typos corrected, references added, 30 pages + Appendix (10 pages), 11 Tables, accepted for publication in Communications in Mathematical Physics