title: ÐÐ¾Ð»ÐµÐºÑÐ»ÑÑÐ½Ð¾-Ð³ÐµÐ½ÐµÑÐ¸ÑÐµÑÐºÐ°Ñ Ñ Ð°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸ÐºÐ° ÑÐµÑÐ¿Ð¸ÑÐ°ÑÐ¾ÑÐ½Ð¾Ð³Ð¾ ÑÐ¸Ð½ÑÐ¸ÑÐ¸Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ Ð²Ð¸ÑÑÑÐ° ÑÐµÐ»Ð¾Ð²ÐµÐºÐ°, ÑÐ¸ÑÐºÑÐ»Ð¸ÑÑÑÑÐµÐ³Ð¾ Ð½Ð° ÑÐµÑÑÐ¸ÑÐ¾ÑÐ¸Ð¸ Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³Ð° Ð¸ ÐÐµÐ½Ð¸Ð½Ð³ÑÐ°Ð´ÑÐºÐ¾Ð¹ Ð¾Ð±Ð»Ð°ÑÑÐ¸
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ¾Ð»ÑÐºÐ¾Ð², ÐÐ³Ð¾ÑÑ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2016
Subjects: HRSV
F-Ð±ÐµÐ»Ð¾Ðº
ÑÐ¸Ð»Ð¾Ð³ÐµÐ½ÐµÑÐ¸ÑÐµÑÐºÐ¸Ð¹ Ð°Ð½Ð°Ð»Ð¸Ð·
F protein
phylogenetic analysis

description: ÐÐ°Ð½Ð½Ð°Ñ Ð´Ð¸Ð¿Ð»Ð¾Ð¼Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ ÑÐµÑÐ¿Ð¸ÑÐ°ÑÐ¾ÑÐ½Ð¾Ð³Ð¾ ÑÐ¸Ð½ÑÐ¸ÑÐ¸Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ Ð²Ð¸ÑÑÑÐ° ÑÐµÐ»Ð¾Ð²ÐµÐºÐ°, ÑÐ¸ÑÐºÑÐ»Ð¸ÑÑÑÑÐµÐ³Ð¾ Ð½Ð° ÑÐµÑÑÐ¸ÑÐ¾ÑÐ¸Ð¸ Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³Ð° Ð¸ ÐÐµÐ½Ð¸Ð½Ð³ÑÐ°Ð´ÑÐºÐ¾Ð¹ Ð¾Ð±Ð»Ð°ÑÑÐ¸. Ð ÑÐ°Ð±Ð¾ÑÐµ Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½ Ð¾Ð±Ð·Ð¾Ñ Ð»Ð¸ÑÐµÑÐ°ÑÑÑÑ, Ð³Ð´Ðµ Ð¿ÑÐ¸Ð²ÐµÐ´ÐµÐ½Ñ Ð´Ð°Ð½Ð½ÑÐµ Ð¾ ÑÑÑÑÐºÑÑÑÐµ Ð²Ð¸ÑÐ¸Ð¾Ð½Ð°, ÑÑÑÐ¾ÐµÐ½Ð¸Ð¸ Ð³ÐµÐ½Ð¾Ð¼Ð°, Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¿Ð¾Ð²ÐµÑÑÐ½Ð¾ÑÑÐ½ÑÑ Ð±ÐµÐ»ÐºÐ¾Ð², Ð°Ð½ÑÐ¸Ð³ÐµÐ½Ð½ÑÑ ÑÐ²Ð¾Ð¹ÑÑÐ²Ð°Ñ Ð²Ð¸ÑÑÑÐ° Ð¸ ÐµÐ³Ð¾ ÑÐ¸ÑÐºÑÐ»ÑÑÐ¸Ð¸ Ð² Ð¼Ð¸ÑÐµ. Ð¡ÐµÐºÐ²ÐµÐ½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð½ÑÐºÐ»ÐµÐ¾ÑÐ¸Ð´Ð½ÑÑ Ð¿Ð¾ÑÐ»ÐµÐ´Ð¾Ð²Ð°ÑÐµÐ»ÑÐ½Ð¾ÑÑÐµÐ¹, ÐºÐ¾Ð´Ð¸ÑÑÑÑÐ¸Ñ Ð±ÐµÐ»Ð¾Ðº G, Ð±ÑÐ»Ð¾ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¾ Ð´Ð»Ñ 20 Ð¾Ð±ÑÐ°Ð·ÑÐ¾Ð², ÐºÐ¾Ð´Ð¸ÑÑÑÑÐ¸Ñ Ð±ÐµÐ»Ð¾Ðº F - Ð´Ð»Ñ 8 Ð¾Ð±ÑÐ°Ð·ÑÐ¾Ð². ÐÐ¾ÑÐ»Ðµ ÑÑÐ¾Ð³Ð¾ Ð±ÑÐ» Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½ Ð¸Ñ ÑÐ¸Ð»Ð¾Ð³ÐµÐ½ÐµÑÐ¸ÑÐµÑÐºÐ¸Ð¹ Ð°Ð½Ð°Ð»Ð¸Ð·. ÐÐ¾Ð»ÑÑÐµÐ½Ñ ÑÐ»ÐµÐ´ÑÑÑÐ¸Ðµ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ: 1. ÐÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ñ Ð½ÑÐºÐ»ÐµÐ¾ÑÐ¸Ð´Ð½ÑÐµ Ð¿Ð¾ÑÐ»ÐµÐ´Ð¾Ð²Ð°ÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ F-Ð³ÐµÐ½Ð° Ð´Ð»Ñ 8 Ð²Ð¸ÑÑÑÐ¾Ð² Ð¸ G-Ð³ÐµÐ½Ð° Ð´Ð»Ñ 20 Ð²Ð¸ÑÑÑÐ¾Ð². 2. ÐÐ¾ÑÑÑÐ¾ÐµÐ½Ñ ÑÐ¸Ð»Ð¾Ð³ÐµÐ½ÐµÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð´ÐµÑÐµÐ²ÑÑ Ð¿Ð¾ Ð³ÐµÐ½Ð°Ð¼ GÐ¸ F, Ð¿ÑÐ¾Ð¸Ð·Ð²ÐµÐ´ÐµÐ½Ð¾ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ðµ ÑÐ²Ð¾Ð»ÑÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ Ð´Ð¸ÑÑÐ°Ð½ÑÐ¸Ð¸ Ð¼ÐµÐ¶Ð´Ñ Ð¸ÑÑÐ»ÐµÐ´ÑÐµÐ¼ÑÐ¼Ð¸ Ð¸ ÑÐµÑÐµÑÐµÐ½ÑÐ½ÑÐ¼ Ð²Ð¸ÑÑÑÐ¾Ð¼. 3. ÐÐ¾ Ð´Ð°Ð½Ð½ÑÐ¼ ÑÐ¸Ð»Ð¾Ð³ÐµÐ½ÐµÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð¾, ÑÑÐ¾ Ð¾Ð±ÑÐ°Ð·ÑÑ Ð¾ÑÐ½Ð¾ÑÑÑÑÑ Ðº Ð¿Ð¾Ð´Ð³ÑÑÐ¿Ð¿Ðµ ON14. ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½ Ð°Ð½Ð°Ð»Ð¸Ð· Ð°Ð¼Ð¸Ð½Ð¾ÐºÐ¸ÑÐ»Ð¾ÑÐ½ÑÑ Ð¿Ð¾ÑÐ»ÐµÐ´Ð¾Ð²Ð°ÑÐµÐ»ÑÐ½Ð¾ÑÑÐµÐ¹, Ð¿Ð¾ ÐµÐ³Ð¾ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐ°Ð¼ Ð¾Ð±Ð½Ð°ÑÑÐ¶ÐµÐ½Ð¾ Ð±Ð¾Ð»ÑÑÐ¾Ðµ ÑÐ¸ÑÐ»Ð¾ ÑÑÐ°Ð¼Ð¼Ð¾ÑÐ¿ÐµÑÐ¸ÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð·Ð°Ð¼ÐµÐ½.
description: This graduate work is devoted to the study of human respiratory syncytial virus circulating in the territory of St. Petersburg and Leningrad region.Human respiratory syncytial virus is now recognized as the most important viral agent of pediatric lower respiratory tract illness (LRI) worldwide.This work includes a review of the literature, which shows the virion structure, genome structure, organization of surface proteins, antigenic properties of the virus and its circulation in the world.Sequencing of the gene encoding protein G, was performed for 20 samples, gene encoding a protein F - for 8 samples. After that phylogenetic analysis was conducted.This graduate work presents the following results:1. Nucleotide sequences of the F-gene and G-gene for 8 and 20 samples respectively.2. Phylogenetic trees for genes G and F, and a comparison of evolutionary distance between the study and the reference virus were performed. 3. Phylogenetic analysis revealed that the samples belong to subgroup ON14. The analysis of amino acid sequences showed large amount of strain-specific amino acid changes.