cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A comparative morphometric analysis of the sensory hair cells of the cochleas of echolocating mammals
Creators: name: Girdlestone, Cassandra Dawn
Publisher: name: University of British Columbia
Year: 2019

description: Morphometric analysis of the inner ear of mammals can provide information for cochlear frequency mapping, which can determine the encoding frequency of lesions in the cochlea resulting from noise-induced hearing loss. A frequency map is a species-specific designation of the locations in the cochlea at which different sound frequencies are encoded. If the frequency map is known and there is a lesion in the cochlea due to noise exposure, the related frequencies of the anthropogenic source may be determined. Morphometric variation occurs in cells of the organ of Corti from the apex to the base of the cochlea. The base of the cochlea encodes for high frequency sounds, while low frequencies are detected in the apex. These changes in cell shape and spacing are linked to the frequencies detected at different locations, which has previously been shown in the guinea pig (Cavia porcellus). Here, we show that morphometric analysis also seems to be a viable alternative to physiological techniques when predicting the frequency as a function of location in other mammals, including those that echolocate. Parnell’s mustached bat (Pteronotus parnellii) already has a well-documented frequency map to compare morphometric measurements to. Using both traditional and geometric morphometrics to analyze scanning electron micrographs, our research shows a relationship between cochlear morphometrics in six mustached bats and their frequency map. Traditional morphometrics were also collected in a Wistar rat (Rattus norvegicus). These results from both species were further compared to traditional morphometrics measured in beluga whales (Delphinapterus leucas). Five out of eight morphometric parameters analyzed showed a strong similarity in their trends along the cochlea, including the distance between the rows of hair cells, width of outer hair cells, and gap width between hair cells. Using a multiple linear regression model revealed that five parameters are responsible for 83.5% of the variation in these morphometric data. Based on this information we created the first cochlear frequency map for the beluga whale. Determining the biologically relevant measurements related to frequency detection can give us a greater understanding of how hearing works and how it is affected by anthropogenic noise.
Pilot study: Split-half reliability analysis – R output (HTML) - The consumer perception of local food through different types of proximity
Creators: name: Laszlo, Veronika
Publisher: name: Zenodo
Year: 2025
Subjects: split-half reliability
pilot study

description: This record contains the R Markdown output (.nb.html) of a split-half reliability analysis conducted in the pilot phase of a doctoral research project.

The analysis focuses on assessing the internal consistency of consumer proximity scale items used to evaluate sustainable local food systems. The file includes the full R code and the resulting output for the pilot dataset.

The output was generated in R using R Markdown and is shared for transparency and reproducibility.

Author: Veronika LászlóAccess status: Embargoed until the dissertation defense. This record is available to reviewers via a private link.
Diversité des races locales de porcs et des systèmes de production pour des produits traditionnels de qualité et des filières porcines durables : présentation du projet TREASURE
Creators: name: ČANDEK-POTOKAR, Marjeta
name: FONTANESI, Luca
name: GIL, José María
name: LEBRET, Bénédicte
name: NIETO, Rosa
name: OLIVER, Maria Angels
name: OVILO, Cristina
name: PUGLIESE, Carolina
Publisher: name: Zenodo
Year: 2019

description: Le projet propose un nouveau paradigme de la production porcine qui vise à développer des filières durables basées sur les races locales sous-exploitées. Le programme vise à répondre aux attentes des consommateurs pour la qualité des produits régionaux traditionnels et aux exigences sociétales concernant l'environnement, le bien-être animal et le développement rural. Les objectifs sont de mieux caractériser les races porcines locales, en particulier les races actuellement sous-exploitées, aux niveaux phénotypique et génétique (avec l’utilisation des nouveaux outils génomiques), d’évaluer leurs performances dans leur système de production spécifique, d’étudier les effets des pratiques d’élevage notamment la valorisation des ressources alimentaires locales, d’évaluer les besoins nutritionnels de ces animaux et l’impact environnemental de la production, et de mieux comprendre le lien entre les pratiques d’élevage et la qualité intrinsèque des produits traditionnels ou innovants de haute qualité. Les préférences et attitudes des consommateurs, ainsi que les stratégies de commercialisation des produits traditionnels de porcs issus de races locales sont également évaluées. L’ensemble de ces activités a pour but de contribuer à améliorer la durabilité des filières porcines valorisant des races locales. Dans l’esprit du programme H2020 prônant une approche multi-acteurs, le projet TREASURE associe des partenaires de différents secteurs : recherche, développement, services et conseil en agriculture, petites et moyennes entreprises, associations de producteurs afin de créer et renforcer les interactions entre la recherche, le développement et les filières de production et de renforcer l’impact des travaux de recherches et le transfert de connaissances vers les utilisateurs.
Metallicities of galaxies in the nearby Lynx-Cancer void
Creators: name: Kniazev, A.
name: Pustilnik, S.
name: Tepliakova, A.
name: Burenkov, A.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Does the void environment have a sizable effect on the evolution of dwarf galaxies? If yes, the best probes should be the most fragile least massive dwarfs. We compiled a sample of about one hundred dwarfs with M_B in the range -12 to -18 mag, falling within the nearby Lynx-Cancer void. The goal is to study their evolutionary parameters -- gas metallicity and gas mass-fraction, and to address the epoch of the first substantial episode of Star Formation. Here we present and discuss the results of O/H measurements in 38 void galaxies, among which several the most metal-poor galaxies are found with the oxygen abundances of 12+log(O/H)=7.12-7.3 dex.
description: 2 pages, one figure. To appear in proceedings of 'Environment and the Formation of Galaxies: 30 years later,' (Lisbon, September 2010), published by Springer-Verlag
Epilepsy-Surgical-Access
Creators: name: Louis, Shreya
Publisher: name: figshare
Year: 2020
Subjects: subject: 110399 Clinical Sciences not elsewhere classified
subject: FOS: Clinical medicine
subject: Diseases
subject: Health Care
subject: 111709 Health Care Administration
subject: FOS: Health sciences
subject: 111712 Health Promotion

description: Project looking at the distribution of Level 4 epilepsy centers with respect to the distribution of Epilepsy patients in the United States.
p-Tower Groups over Quadratic Imaginary Number Fields
Creators: name: McLeman, Cam
Publisher: name: arXiv
Year: 2010
Subjects: subject: Number Theory (math.NT)
subject: Group Theory (math.GR)
subject: FOS: Mathematics
subject: 11R32 (11R37 20D15 20E18 20F05 20F14)

description: The modern theory of class field towers has its origins in the study of the p-class field tower over a quadratic imaginary number field, so it is fitting that this problem be the first in the discipline to be nearing a solution. We survey the state of the subject and present a new cohomological condition for a quadratic imaginary number field to have an infinite p-class field tower (for p odd). Under an additional hypothesis, we refine this to a necessary and sufficient condition and describe an algorithm for evaluating this condition for a given quadratic imaginary number field.
description: 10 pages
General practice in the German Democratic Republic (1949-1990) : a discipline between threat and professionalization
Creators: name: Bruns, Florian
name: König, Christian
name: Frese, Thomas
name: Schildmann, Jan
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 943

description: Background: In the 1950s the socialist health policy in East Germany did not follow a clear-cut course with regard to outpatient medical care. Whilst state-run policlinics gradually took the place of doctors in private practice, the required qualifications of physicians working in outpatient care remained unclear. After preparatory lobbying by committed physicians from the outpatient sector, the 1960 Weimar Health Conference finally paved the way for the preservation and professionalization of general practice in East Germany. Aim: The article analyzes the formation of general practice as a specialty in East Germany between 1945 and 1990. We scrutinize the status of general practitioners and their field in the socialist health system as well as the foundation of their medical society. Our paper aims to contribute to a broader history of general practice in Germany. Methods: We draw on literature from that time, unpublished archival material, and interviews with contemporary witnesses. Results: After the establishment of standards for specialist training in the early 1960s, general practice was introduced as a field of specialty in 1967. By this, East Germany had a compulsory specialist training in general practice much earlier than West Germany. In 1971, a specialist society for general practice was founded in East Germany. However, institutionalization at the medical faculties was still lacking. Meanwhile, the nationalization of outpatient care continued. In the years that followed, primary medical care was increasingly provided in policlinics. In 1989, of 40,000 physicians in the GDR, only about 340 were still practicing in their own offices. Conclusion: Within the nationalized GDR health system a committed group of physicians, under difficult political circumstances, pushed for professionalization of general practice and its recognition as a field of specialty. When general medicine was recognized as a specialty in 1967, this happened earlier than in other countries and constituted an important milestone.
La filosofía de Tales y de Anaxímenes
Creators: name: Perrier, Joseph L.
Publisher: name: Universidad del Rosario
Year: 1915

description: Tales, uno de los siete sabios de Grecia, nació en Mileto, en el Asia Menor, en el año de 640 antes de Cristo, y murió en 550, a la edad de noventa años. Pertenecía a una familia antigua, que descendía de Cadmo, rey de Fenicia...
Clear as mud
Creators: name: Podrecca, Luca
Publisher: name: No Publisher Supplied
Year: 2019

description: The Paleocene/Eocene boundary and attendant Paleocene-Eocene Thermal Maximum (PETM) marks a time of rapid global climatic change. New Jersey shelf sediments of the Marlboro Formation record the PETM with exceptionally thick preservation (up to ~15 m at Wilson Lake) during the period of global low carbon isotopic values (“the core”) which requires minimum sedimentation rates near 10 cm/kyr. Rhythmic layers have previously been reported from both Wilson Lake & Millville, NJ (IODP Leg 174AX). These structures, dubbed ‘couplets’, consist of semi-periodic, 1-2 mm thick, raised laminations separated by typically homogenous sediment layers of varying width averaging 1.27 cm at Medford as opposed to nearly 2 cm at Wilson Lake and Millville. Previous studies have dismissed these structures as artifacts ('drilling biscuits’) produced by drilling mud. I report here on a series of shallow (<65 ft; ~19.81 m) auger cores drilled without using drilling fluid along a downdip transect at Medford, NJ. These cores show similar couplets on the ~1 - 2 cm scale, indicating that they are in fact primary depositional features. The mm-width laminae in the auger cores experienced remarkable swelling within minutes of splitting. XRD, XRF, bulk carbonate geochemistry, and grain size analysis were measured throughout the Medford auger cores. I analyzed differences in these parameters between the laminae and interspersing bulk material, and then made comparisons with data collected at other sites along the New Jersey Coastal Plain (NJCP). I find no uniform discernible difference in lithology between laminae and beds, other than a higher percentage of kaolinite in some laminae. In general, the Marlboro Formation at this updip location consists of micaceous, lignitic, silty clay (mean size < 2 m) with occasional organic debris indicating proximal deposition in a prodelta setting. A paleodepth of ~40 m is estimated from a paleoslope model and normal marine salinities are inferred from the presence of common, though not abundant, planktonic foraminifera. I propose a model of deposition for the Marlboro Formation as being driven by fluid mud (near-bed suspension flows) transport associated with the “Appalachian Amazon”, implying that the extremely fine-grained Marlboro Clay was deposited at Medford as part of a sigmoidal shaped subaqueous clinoform. The clinoform model explains the differential preservation of the Vincentown Formation, transitional units, and the CIE onset, “core”, recovery, and overlying units along a dip transect across the paleoshelf. The laminations discussed here have analogs in modern environments characterized by muddy continental shelves and are associated with episodic or possibly quasi seasonal events of increased riverine discharge and the attendant migration of the benthic salinity front.
Complementarity in atomic and oscillator systems
Creators: name: Srikanth, R.
name: Banerjee, Subhashish
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We develop a unified, information theoretic interpretation of the number-phase complementarity that is applicable both to finite-dimensional (atomic) and infinite-dimensional (oscillator) systems. The relevant uncertainty principle is obtained as a lower bound on {\it entropy excess}, the difference between number entropy and phase knowledge, the latter defined as the relative entropy with respect to the uniform distribution.
description: 5 pages, 2 figures; accepted for publication in Phys. Lett. A
A simplified lower bound for implicational logic
Creators: name: Jeřábek, Emil
Publisher: name: arXiv
Year: 2023
Subjects: subject: Logic in Computer Science (cs.LO)
subject: Logic (math.LO)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics
subject: 03F20 (Primary) 03B20 (Secondary)

description: We present a streamlined and simplified exponential lower bound on the length of proofs in intuitionistic implicational logic, adapted to Gordeev and Haeusler's dag-like natural deduction.
description: 32 pages; mention effects of recent improved circuit lower bounds
Clusters in Light Nuclei
Creators: name: Beck, C.
name: Papka, P.
name: Zafra, A. Sanchez i
name: Thummerer, S.
name: Azaiez, F.
name: Bednarczyk, P.
name: Courtin, S.
name: Curien, D.
name: Dorvaux, O.
name: Goasduff, A.
name: Lebhertz, D.
name: Nourreddine, A.
name: Rousseau, M.
name: Salsac, M. -D.
name: von Oertzen, W.
name: Gebauer, B.
name: Wheldon, C.
name: Kokalova, Tz.
name: Efimov, G.
name: Zherebchevsky, V.
name: Schulz, Ch.
name: Bohlen, H. G.
name: Kamanin, D.
name: de Angelis, G.
name: Gadea, A.
name: Lenzi, S.
name: Napoli, D. R.
name: Szilner, S.
name: Milin, M.
name: Catford, W. N.
name: Jenkins, D. G.
name: Royer, G.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: A great deal of research work has been undertaken in the alpha-clustering study since the pioneering discovery, half a century ago, of 12C+12C molecular resonances. Our knowledge of the field of the physics of nuclear molecules has increased considerably and nuclear clustering remains one of the most fruitful domains of nuclear physics, facing some of the greatest challenges and opportunities in the years ahead. In this work, the occurence of "exotic" shapes in light N=Z alpha-like nuclei is investigated. Various approaches of superdeformed and hyperdeformed bands associated with quasimolecular resonant structures are presented. Results on clustering aspects are also discussed for light neutron-rich Oxygen isotopes.
description: 12 pages, 5 figures. Invited Talk presented by C. Beck at the Zakopane Conference on Nuclear Physics "Extremes of the Nuclear Landscape" XLV in the series of Zakopane Schools of Physics - International Symposium - Zakopane, Poland, August 30 - September 5, 2010.To be publihed in Acta Physica Polonica B42 no 3, March 2011
Modulation stabilization of Bloch oscillations of two-component Bose-Einstein condensates in optical lattices
Creators: name: Gu, Huai-Qiang
name: An, Jun-Hong
name: Jin, Kang
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We study the Bloch oscillations (BOs) of two-component Bose-Einstein condensates (BECs) trapped in spin-dependent optical lattices. Based on the derived equations of motion of the wave packet in the basis of localized wave functions of the lattice sites, the damping effect induced by the intercomponent and intracomponent interactions to the BOs is explored analytically and numerically. We also show that such damping of the BOs can be suppressed entirely if all the atom-atom interactions are modulated synchronously and harmonically in time with suitable frequency via the Feshbach resonance. When the intercomponent and the intracomponent interactions have inverse signs, we find that the long-living BOs and even the revival of the BOs can be achieved via only statically modulating the configuration of optical lattices. The results provide a valuable guidance for achieving long-living BOs in the two-component BEC system by the Feshbach resonances and manipulating the configuration of the optical lattices.
description: 13 pages in IOP preprint style, 5 figures
Remarks on the stability of Cartesian PMLs in corners
Creators: name: Bécache, Eliane
name: Prieto, Andres
Publisher: name: arXiv
Year: 2011
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: This work is a contribution to the understanding of the question of stability of Perfectly Matched Layers (PMLs) in corners, at continuous and discrete levels. First, stability results are presented for the Cartesian PMLs associated to a general first-order hyperbolic system. Then, in the context of the pressure-velocity formulation of the acoustic wave propagation, an unsplit PML formulation is discretized with spectral mixed finite elements in space and finite differences in time. It is shown, through the stability analysis of two different schemes, how a bad choice of the time discretization can deteriorate the CFL stability condition. Some numerical results are finally presented to illustrate these stability results.
Landscapes, maps and territories of open education policy … where do we go from here?
Creators: name: Havemann, Leo
name: Atenas, Javiera
Publisher: name: Zenodo
Year: 2021

description: As we know, a map is not the same thing as the territory it claims to represent. A landscape whether viewed, photographed or painted again attempts representation, but is a snapshot of a moment, taken from a certain angle. The territory always contains so much more, so much that is unknown. We have recently been working on the topic of OE policy from the angles of landscape and maps; collecting, curating and reviewing in order to build up a big picture of the current state of policy, and trying to devise pathways towards desired policy destinations. In both cases the territory that concerns us, that we are trying to understand and navigate, is the real world of the lived experience of learning, teaching, creation and collaboration inside and outside of educational organisations, by educators, and of those who seek learning through formal or other channels. This territory is also a research field, within which the limits or remit of OE remain an open question. OE researchers increasingly consider interrelationships between open content, practices, and educators, and between the practices engaged in and the reasons for doing so. In this session we propose to discuss findings from our review of the makeup of the current landscape of OE policy, to highlight the current direction of travel. Furthermore, we will argue that in seeking pathways towards open futures, we may need to recalibrate our instruments to better reflect the rich and complex territory of actual practices.
Wayward Leviathans: How America's Corporations Lost Their Public Purpose
Creators: name: Ciepley, David
Publisher: name: University of Notre Dame
Year: 2023

description: On its glittering surface, America's corporate economy appears to be in fantastic shape. The stock markets recently reached record highs, even if they dipped and bobbed after reaching those heights. Profits are soaring. Financing is cheap. The corporate tax rate has been cut. The unemployment rate is near a fifty-year low, with little inflation. But look under the hood, and you will find that all is not well. Those stock prices have little, if anything, to do with underlying value creation; those profits owe little to increased productivity; that cheap financing seldom goes to investment. Despite the record profits and unusually favorable terms for borrowers, the rate of corporate investment is down--by historical standards for such conditions, way down. Productivity growth is down. Wages, adjusted for inflation, have remained largely flat since the 1970s, despite all of labor's subsequent productivity gains. As a proportion of corporate income, wage expenditure today is at a historic low, even with profits at or near historic highs. Profits that used to be allocated to wage increases, training, research, and expansion are instead being disgorged to stockholders in the form of increased dividends and stock buybacks (which helps explain those rising stock prices). The windfall from the 2017 corporate tax cut went almost entirely to such buybacks, not wages or investment. The number of listed companies is actually declining, in part because entrepreneurs who wish to grow their companies dare not place them under Wall Street's care, to be bled out for the pleasure of today's short-term-focused stockholders. Today's stockholder is fat and happy from cannibalizing the corporate body. Yet the feast is unlikely to last. There is only so much dining to be done on a host that is not allowed to feed itself. These may be flush times for the American corporation, but the bounty is not being translated into a prosperity that is sustainable or broad. How has the corporation's vision become so foreshortened? Its largess so narrowly bestowed? Its malfeasance so widespread? Viewed from the perspective of history, the American business corporation has lost its way.
Un pedagogo en la época del renacimiento
Creators: name: Pastor, Ludovigo
Publisher: name: Universidad del Rosario
Year: 1913

description: Fragmento tomado del libro La historia de los Papas después de la Edad Media. Describe a uno de los mas importantes representantes del Renacimiento Cristiano: Victorino de Feltre. El texto explica como Victorino empezó su obra, su sistema de enseñanza y, el legado que dejó.
On Weyl sums for smaller exponents
Creators: name: Boklan, Kent D.
name: Wooley, Trevor D.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11L15, 11L07, 11P05, 11P55

description: We present a hybrid approach to bounding exponential sums over kth powers via Vinogradov's mean value theorem, and derive estimates of utility for exponents k of intermediate size.
Sobre el estudio de las lenguas
Creators: name: Restrepo Millan, José María
Publisher: name: Universidad del Rosario
Year: 1913

description: Tesis donde se estudia la influencia ejercida en las diversas ramas de la educación, por el estudio de las lenguas. Dentro de la tesis se estudia la educación física, la intelectual y la moral, la educación artística y la social y política.
Confusion in electromagnetism and implications of CPT symmetry -- system of units associated with symmetry
Creators: name: Ichiguchi, Tsuneo
Publisher: name: arXiv
Year: 2010
Subjects: subject: General Physics (physics.gen-ph)
subject: FOS: Physical sciences

description: We discuss the universal constants c, epsilon, and h in relation to the CPT symmetry. Because MKSA units (S.I. units) have no essential meaning, we should use the units where c^2=epsilon^2=h^2=1. When volume is negative in the left-handed coordinates as written in the Maxwell's text book, epsilon is also negative in the left-handed coordinates. Thus, we need to have negative values of the universal constants. If their absolute value is unity, the light velocity is a time-reversal operator, permitivity is a space-reversal operator, and the Plank constant is an operator for wave-particle transformation. This paper shows new concepts in fundamental physics although it was written for nonspecialists.
description: pdf 17 Pages
Modelling the public health impact of MenACWY and MenC adolescent vaccination strategies in Germany
Creators: name: Gruhn, Sebastian
name: Batram, Manuel
name: Wick, Moritz
name: Langevin, Edith
name: Scholz, Stefan
name: Greiner, Wolfgang
name: Damm, Oliver Siegfried
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 610

description: Introduction: Invasive meningococcal disease (IMD) causes significant mortality and long-term sequelae. This study assesses the potential public health impact of adolescent vaccination strategies employing MenACWY and MenC vaccines in Germany, where the existing meningococcal immunisation programme predominantly involves MenC administration in toddlers. Methods: A dynamic transmission model was developed to simulate the carriage of five meningococcal serogroup compartments (AY/B/C/W/ Other) from 2019 until 2060 within 1-year age groups from 0 to 99 years of age. IMD cases were estimated based on case-carrier ratios. The model considered vaccine effectiveness against carriage acquisition and IMD. Results: The model predicts that introducing MenACWY adolescent vaccination could lead to a considerable reduction in IMD incidence, with the potential to prevent up to 65 cases per year and a cumulative total of 1467 cases by 2060. This decrease, mainly driven by herd effects, would result in a reduction of IMD incidence across all age groups, regardless of vaccination age. Furthermore, implementing MenACWY vaccination in adolescents is projected to decrease annual MenACWY-related IMD mortality by up to 64%, equating to an overall prevention of 156 IMD deaths by 2060. These protective outcomes are expected to culminate in approximately 2250 life years gained (LYG) throughout the model’s projected time horizon. In contrast, the adoption of MenC vaccination in adolescents is predicted to have minimal influence on both IMD incidence and mortality, as well as on LYG. Conclusion: The results of this study demonstrate that implementing MenACWY vaccination for adolescents in Germany is likely to notably reduce IMD incidence and mortality across age groups. However, the introduction of MenC adolescent vaccination shows only limited impact. Considering the extensive healthcare resources typically required for IMD management, these findings suggest the potential for economic benefits associated with the adoption of MenACWY adolescent vaccination, warranting further cost-effectiveness analysis.
rAAV9 mediated PAX6 gene transfer temporarily reverses corneal epithelial thinning in a mouse model of aniridia
Creators: name: Hickmott, Jack William
Publisher: name: University of British Columbia
Year: 2020

description: Aniridia is a rare, congenital, blinding disorder, caused by mutations in the paired box 6 (PAX6) gene. People with aniridia are born with poor vision, which deteriorates towards blindness in early adulthood due to glaucoma and aniridia associated keratopathy. Glaucoma can be managed by conventional treatments, however interventions for keratopathy fail to provide lasting vision. Aniridia is caused by haploinsufficiency, where the underlying cause of the phenotype is insufficient production of PAX6. Therefore, PAX6 augmentation is a possible approach to treating aniridia. Gene therapy, defined as the manipulation of gene expression, or repair of abnormal genes, has recently demonstrated clinical success, providing therapeutics for genetic disorders such as lipoprotein lipase, Leber's congenital amaurosis, spinal muscular atrophy, and hemophilia B. All of these gene therapies use recombinant adeno associated viruses (rAAV) as a vector to transfer genes to patient cells, augmenting protein production. However, PAX6 is a potent morphogen, and using gene transfer technologies to express PAX6 ectopically risks detrimental effects in off target cells. Therefore, towards developing a PAX6 gene therapy for aniridia, I tested PAX6 minimal promoters (MiniPromoters) to restrict gene expression from rAAV to cells that endogenously express PAX6. Using regulatory regions from the PAX6 gene, seven MiniPromoters were tested, and four were found to restrict expression to the four cell types that express PAX6 in the adult retina. Most gene therapies begin in a mouse model before they are tested clinically. Therefore, before I began testing PAX6 gene transfer, I studied the Small eye (Sey) mouse model of aniridia to define therapeutic targets for PAX6 gene transfer, and to quantify phenotypic features of clinical interest. These studies identified the cornea as a target with a clinically relevant phenotype, epithelial thinning, which I could target for gene transfer. Finally, I tested PAX6 gene transfer to the Sey mouse cornea by injecting rAAV encoding a PAX6 open reading frame (ORF) directly into the cornea. These tests revealed that PAX6 gene transfer to the cornea transiently reverses corneal epithelial thinning in Sey mice, and lays the foundation for the development of a gene therapy for aniridia.
Spatial dynamics, stage-structure, and the predator-prey interactions of largemouth bass (Micropterus salmoides)
Creators: name: T.E., Essington,
Publisher: name: University of Notre Dame
Year: 2023

description: Largemouth bass are important predators in lake ecosystems, exerting strong top-down control on fish communities. Although the effect of bass on fish communities is well known, there is only marginal understanding of the underlying processes dictating bass predation rates. For example, the spatial aspects of bass-prey interactions are poorly understood. Moreover, bass are often components of complex food webs, where bass both prey upon and compete with other fishes owing to stage-structured population dynamics. I explored the interactions between bass and their prey by considering three distinct questions: 1) How do predator-prey interactions affect fish spatial distributions and habitat use ? 2) Is satiation an important constraint on bass predation rates ? 3) Can complex food webs lead to alternate stable states in bass and prey abundance? I combined long-term data analysis, whole-lake manipulations, and modeling analysis to explore how predator-prey interactions dictate fish distributions, and the consequences of these distributions for bass predation. At high prey densities, bass do not seek out aggregations of prey, but instead follow a fixed behavior pattern that creates a non-random distribution of predation risk. This behavior creates a refuge for prey in the locations uncommonly inhabited by bass. This simple anti-predator behavior becomes an important constraint on bass predation rates. As a consequence, bass predation rates are always well below their physiological maximum, even when prey are abundant. Lastly, I developed a general model of intraguild predation in stage-structured populations. This model suggests that intraguild predation promotes alternate steady states, where populations are alternately controlled by predation or competition. However, likelihood of such steady states depends on the intensity of density-dependent processes. Collectively, these results highlight the importance of individual behavior in mediating population-level phenomenon, and the importance of stage-structure in predator-prey interactions.
A bound for Mean values of Fourier transforms
Creators: name: Weber, Michel
Publisher: name: arXiv
Year: 2011
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: Primary: 60F15, 60G50, Secondary: 60F05

description: We show that there exists a sequence $\{n_k, k\ge 1\}$ growing at least geometrically such that for any finite non-negative measure $ν$ such that $\hat ν\ge 0$, any $T>0$, $$ \int_{-2^{n_k} T}^{2^{n_k} T} \hat ν(x) \dd x \ll_\e T\,2^{2^{(1+\e)n_k}} \int_\R \Big|{\sin {xT} \over xT} \Big|^{n_k^2} ν(\dd x). $$
Strategic Internal Audit Proficiency on Sustainable Audit Success An Empirical Investigation of Listed firms in Thailand
Creators: name: Suwan Wangcharoendate
Publisher: name: Stamford International University Thailand
Year: 2019
Subjects: strategic internal audit proficiency, sustainable audit success, internal audit innovation orientation, dynamic internal audit integration, proactive internal audit awareness.

description: ASEAN Journal of Management & Innovation, 6, 1, p 200 - 211
Spectral Index as a Function of Mass Accretion Rate in Black Hole Sources. Monte-Carlo Simulations and an Analytical Description
Creators: name: Laurent, Philippe
name: Titarchuk, Lev
Publisher: name: arXiv
Year: 2010
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: In this Paper, we present theoretical arguments that the observationally established index saturation effect vs mass accretion rate is a signature of the bulk (converging) flow onto the black hole. We demonstrate that the index saturation value depends on the plasma temperature of converging flow. We self-consistently calculate the Compton cloud (CC) plasma temperature as a function of mass accretion rate using the energy balance between energy dissipation and Compton cooling. We explain the observable phenomenon, index- mdot correlations using a Monte-Carlo simulation of radiative processes in the innermost part (CC) of a BH source and we account for the Comptonization processes in the presence of thermal and bulk motions, as basic types of plasma motion. We show that, when mdot increases, BH sources evolve to high and very soft states (HSS and VSS, respectively), in which the strong blackbody-like and steep power-law components are formed in the resulting X-ray spectrum. The simultaneous detections of these two components strongly depends on sensitivity of high energy instruments, given that the relative contribution of the hard power-law tail in the resulting VSS spectrum can be very low, which is why, to date {\it RXTE} observations of the VSS X-ray spectrum has been characterized by the presence of the strong BB-like component only. We also predict specific patterns for high-energy efold (cutoff) energy (E_{fold}) evolution with mdot for thermal and dynamical (bulk) Comptonization cases. For the former case, E_{fold} monotonically decreases with mdot, in the latter case, the E_{fold}-decrease is followed by its increase at high values of mdot. The observational evolution of E_{fold} vs mdot can be one more test for the presence of a converging flow effect in the formation of the resulting spectra in the close vicinity of BHs.
description: 15 pages, 11 figures, accepted for the publication in the Astrophysical Journal
An Analysis of the Factors Affecting Intention to Use Artificial Intelligence Technology in Learning: A Case Study of Hanoi Students
Creators: name: Dang, Hien Le
Publisher: name: Stamford International University Thailand
Year: 2020
Subjects: Artificial Intelligence
Usage Intention
Student Learning
TR
TAM
Vietnam

description: ASEAN Journal of Management & Innovation, 7, 2, 1 - 16
3D Simulation of Nanowire FETs using Quantum Models
Creators: name: Patnaik, Vijay Sai
name: Gheedia, Ankit
name: Kumar, M. Jagadesh
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: After more than 30 years of validation of Moore's law, the CMOS technology has already entered the nanoscale (sub-100nm) regime and faces strong limitations. The nanowire transistor is one candidate which has the potential to overcome the problems caused by short channel effects in SOI MOSFETs and has gained signifi - cant attention from both device and circuit developers. In addition to the effective suppression of short channel effects due to the improved gate strength, the multi-gate NWFETs show excellent current drive and have the merit that they are compatible with conventional CMOS processes. To simulate these devices, accurate modeling and calculations based on quantum mechanics are necessary to assess their performance limits, since cross-sections of the multigate NWFETs are expected to be a few nanometers wide in their ultimate scaling. In this paper we have explored the use of ATLAS including the Bohm Quantum Potential (BQP) for simulating and studying the shortchannel behaviour of nanowire FETs.
description: http://www.silvaco.com/tech_lib_TCAD/simulationstandard/latest.html
Bibliogafía colombiana
Creators: name: Mora, Luis María¬Carrasquilla, Rafael María¬Gómez Restrepo, Antonio
Publisher: name: Universidad del Rosario
Year: 1913

description: Compendio de fragmentos de diferentes libros donde se hace un pequeño análisis, o se recomienda la obra de escritores colombianos o, relacionados con Colombia. Entre estos se encuentran José Joaquin Casa, Fray Pedro Fabo, Antonio Otero Herrera, Martín Restrepo Mejía, Roberto Cortazar, Francisco M. Rengifo.
An Educational Management Approach in Total Support for Thai Undergraduates' Learning and Performance Behaviour
Creators: name: Chetthapoom Wannapaisan
Publisher: name: Stamford International University Thailand
Year: 2020
Subjects: Classmates
Course Design
Encouraging
Family
Focusing
Humble
Learning
Performance
Responsibility
Understanding

description: ASEAN Journal of Management & Innovation, 7, 2, 92 - 107
Prólogo de un libro
Creators: name: Carrasquilla, Rafael María
Publisher: name: Universidad del Rosario
Year: 1913

description: Descripción del libro San Francisco de Asís. Su vida y su obra. El autor resalta la importancia de la traducción de este texto al castellano, ya que la hagiografía o biografía de los santos permite conocer los aspectos sobrenaturales y naturales de los personajes, en este caso, San Francisco de Asís.
Pre-validation: Test–retest reliability (R output) - The consumer perception of local food through different types of proximity
Creators: name: Laszlo, Veronika
Publisher: name: Zenodo
Year: 2025
Subjects: test–retest reliability

description: This file contains the R Markdown output (.nb.html) of the test–retest reliability analysis conducted in the pre-validation phase of a doctoral research project. 

The script and resulting output cwere used to assess the temporal stability of proximity-related consumer constructs. The file includes raw data handling, visual checks, descriptive statistics, and reliability coefficients.

The script was executed in R using R Markdown and exported for transparency and reproducibility purposes.

Author: Veronika LászlóAccess status: Embargoed until dissertation defense. The file is accessible via private link for reviewers only.
The Carina Project. IV. radial velocity distribution
Creators: name: Fabrizio, M.
name: Nonino, M.
name: Bono, G.
name: Ferraro, I.
name: François, P.
name: Iannicola, G.
name: Monelli, M.
name: Thévenin, F.
name: Stetson, P. B.
name: Walker, A. R.
name: Buonanno, R.
name: Caputo, F.
name: Corsi, C. E.
name: Dall'Ora, M.
name: Gilmozzi, R.
name: James, C. R.
name: Merle, T.
name: Pulone, L.
name: Romaniello, M.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present new and accurate radial velocity (RV) measurements of luminous stars of all ages (old horizontal branch, intermediate--age red clump, and young blue plume, as well as red giants of a range of ages; 20.6
description: Accepted on PASP, 9 pages, 13 figures, 1 table
Competing Internationally for the Chinese Tourist Market with Consideration for Local Thai Residents
Creators: name: Korawan Sangkakorn
Publisher: name: Stamford International University Thailand
Year: 2020
Subjects: subject: Chinese Travelers
subject: Cultural Impact
subject: Information
subject: Marketing
subject: FOS: Economics and business
subject: Promoting Tourism

description: ASEAN Journal of Management & Innovation, 7, 2, 48 - 63
Creativity Organizational Innovation and Firm Success: An Empirical study of Electronic and Electrical Appliance Business in Thailand
Creators: name: Suwan Wangcharoendate
Publisher: name: Stamford International University Thailand
Year: 2020
Subjects: Organizational Creativity and Innovation
Firm Success
Valuable Practice Development
New Process Improvement
Proactive Operational Competency

description: ASEAN Journal of Management & Innovation, 7, 2, 108 - 120
Rancangan Peraturan Desa Tentang Pengadaan Dan Pengelaan Air Bersih
Creators: name: Dr. Ahmad Sholikhin Ruslie, SH., MH.
name: Rozaan, Faris Septyan
Publisher: name: Zenodo
Year: 2022

description: Rancangan Peraturan Desa Tentang Pengadaan Dan Pengelolaan Air Bersih Di Desa Wonokerto Kecamatan Wonosalam Kabupaten Jombang Jawa Timur
Enhancing Onboard Safety: Planning for the Non-Technical Skills Training of the Cabin Crews of an International Airline
Creators: name: Thatri Kwansang
Publisher: name: Stamford International University Thailand
Year: 2020
Subjects: on-Technical Skills
Enhanced Safety
Cabin Crew
Planning for EducationalTraining
International Airline

description: ASEAN Journal of Management & Innovation, 7, 2, 78 - 91
Influence of Cultural Differences and Interest Level in Thai Culture on the Online Shopping Behavior of Chinese Consumers
Creators: name: Yolamas Jeerasantikul
Publisher: name: Stamford International University Thailand
Year: 2020
Subjects: Purchase Decision
Cultural Factor
Online Shopping
Consumer Attitude
Influence

description: ASEAN Journal of Management & Innovation, 7, 2, 121 - 134
Endoplasmic reticulum : nanodomain organization and communication with mitochondria
Creators: name: Gao, Guang
Publisher: name: University of British Columbia
Year: 2021

description: Communications between the endoplasmic reticulum (ER) and mitochondria occur at specialized nanodomains, ER-mitochondria contact sites, which are hubs for calcium signaling, lipid transport, mitochondrial biogenesis, and mitochondrial DNA distribution. Thus, the regulation of ER-mitochondria contacts is vital for the cell. In this dissertation, I elucidate the regulation of ER-mitochondria contacts and the nanodomain organization of the ER and present a 3D whole-cell ER-mitochondria contact map. Firstly, Autocrine Motility Factor Receptor (Gp78) is localized throughout the ER with a subpopulation of mitochondria-associated ER labeled by anti-Gp78 3F3A. The epitope that 3FA binds is localized to an 8 amino acid motif that contains Ser-538, a major p38 MAPK phosphorylation site on Gp78. Gp78 S538 phosphorylation limits Gp78 ability to enhance ER-mitochondria contacts, induce mitochondrial fission and degrade mitofusin1/2 but does not impact Gp78 in vitro E3 ubiquitin ligase activity. p38 MAPK phosphorylation of Gp78 S538, therefore, regulates Gp78-dependent ER-mitochondria contacts and mitochondria dynamics. Secondly, diffraction-limited microscopy has hindered efforts to study nanodomains of ER and ER-mitochondria contacts. Here, STimulated emission depletion (STED) super-resolution microscopy reveals nanodomain/periodicity (maxima and minima) of ER tubules. Lumenal (ERmoxGFP) and membrane (Sec61βGFP) ER reporters are enriched at distinct nanodomains of peripheral ER tubules. Derlin-1 and calnexin are significantly enriched only in the periodic ER lumenal minima, which is disrupted by CLIMP-63 knockdown. Overexpression of CILMP-63 or reticulon alters ER tubule nanodomain organization and the preferential distribution of calnexin to ER nanodomains. This suggests that CLIMP-63 and reticulon define, segregate, and organize lumenal ER nanodomains from ER membrane protein complexes. Lastly, the ER presents tubules and sheets. However, the studies of ER-mitochondria mostly focus on ER tubule-mitochondria contacts. In this work, EM and live cell imaging show distinct types of ER-mitochondria contacts. 3D STED shows that the ER contains peripheral tubules, peripheral fenestrated sheets, and central sheet-like structures and further that all these ER structures contact with mitochondria. Thus, the application of super-resolution microscopy to ER-mitochondria contacts has identified multiple types of ER-mitochondria contacts in 3D, which will open up new avenues on ER-mitochondria contact studies.
EXOTIME: searching for planets around pulsating subdwarf B stars
Creators: name: Schuh, Sonja
name: Silvotti, Roberto
name: Lutz, Ronny
name: Loeptien, Bjoern
name: Green, Elizabeth M.
name: Ostensen, Roy H.
name: Leccia, Silvio
name: Kim, Seung-Lee
name: Fontaine, Gilles
name: Charpinet, Stephane
name: Francoeur, Myriam
name: Randall, Suzanna
name: Rodriguez-Lopez, Cristina
name: van Grootel, Valerie
name: Odell, Andrew P.
name: Paparo, Margit
name: Bognar, Zsofia
name: Papics, Peter
name: Nagel, Thorsten
name: Beeck, Benjamin
name: Hundertmark, Markus
name: Stahn, Thorsten
name: Dreizler, Stefan
name: Hessman, Frederic V.
name: Dall'Ora, Massimo
name: Mancini, Dario
name: Cortecchia, Fausto
name: Benatti, Serena
name: Claudi, Riccardo
name: Janulis, Rimvydas
Publisher: name: arXiv
Year: 2010
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: In 2007, a companion with planetary mass was found around the pulsating subdwarf B star V391 Pegasi with the timing method, indicating that a previously undiscovered population of substellar companions to apparently single subdwarf B stars might exist. Following this serendipitous discovery, the EXOTIME (http://www.na.astro.it/~silvotti/exotime/) monitoring program has been set up to follow the pulsations of a number of selected rapidly pulsating subdwarf B stars on time-scales of several years with two immediate observational goals: 1) determine Pdot of the pulsational periods P 2) search for signatures of substellar companions in O-C residuals due to periodic light travel time variations, which would be tracking the central star's companion-induced wobble around the center of mass. These sets of data should therefore at the same time: on the one hand be useful to provide extra constraints for classical asteroseismological exercises from the Pdot (comparison with "local" evolutionary models), and on the other hand allow to investigate the preceding evolution of a target in terms of possible "binary" evolution by extending the otherwise unsuccessful search for companions to potentially very low masses. While timing pulsations may be an observationally expensive method to search for companions, it samples a different range of orbital parameters, inaccessible through orbital photometric effects or the radial velocity method: the latter favours massive close-in companions, whereas the timing method becomes increasingly more sensitive towards wider separations. In this paper we report on the status of the on-going observations and coherence analysis for two of the currently five targets, revealing very well-behaved pulsational characteristics in HS 0444+0458, while showing HS 0702+6043 to be more complex than previously thought.
description: Contribution to: The Fourth Meeting on Hot Subdwarf Stars and Related Objects, 20 - 24 July 2009, Shanghai, China, published 03/2010 by Ap&SS (Open access publication). 12 pages, 14 figures, 5 tables