cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A study on the ameliorative effects of goldenseal, goat's rue extracts, and berberine on glucose uptake compared to metformin in a cellular model
Creators: name: Kumar Kandunuri and Kenneth White, Kiran
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 310103
subject: Cell metabolism

description: This study examines the effects of goat's rue (Galega officinalis L.), goldenseal (Hydrastis canadensis L.) leaves, root extracts, and berberine on glucose uptake in HepG2 cells. These plant compounds, traditionally used to alleviate diabetes symptoms, were compared to metformin. Glucose uptake was assessed using 2-NBDG, MTT assays for cytotoxicity, Bradford protein assays, and western blotting for GLUT-1 expression. Goldenseal and berberine significantly increased glucose uptake compared to metformin (p<0.05). Berberine, goldenseal, and metformin enhanced glucose uptake by 3.4, 2, and 1.8 times respectively (p<0.001). GLUT-1 expression increased by 1.7 times with goldenseal and 1.4 times with berberine (p<0.05). The results indicate that berberine is more effective than goldenseal in improving glucose uptake, suggesting both may lower blood glucose levels in insulin resistance, and present potential therapeutic alternatives for Type 2 Diabetes.
Supplemental material for Induced expression of Toll-like receptor 9 in peritubular capillary endothelium correlates with the progression of tubulointerstitial lesions in autoimmune disease-prone mice
Creators: name: M A Masum
name: O Ichii
name: Y H A ELewa
name: Y Kon
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 111702 Aged Health Care
subject: FOS: Health sciences

description: Supplemental Material for Induced expression of Toll-like receptor 9 in peritubular capillary endothelium correlates with the progression of tubulointerstitial lesions in autoimmune disease-prone mice by M A Masum, O Ichii, Y H A ELewa and Y Kon in Lupus
PHP827616_Supplemental_Material – Supplemental material for Studying Vector-Borne Disease Transmission in Public Health Education Using a Geospatial Curriculum Approach
Creators: name: Rajika Emily Reed
name: Bodzin, Alec
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, PHP827616_Supplemental_Material for Studying Vector-Borne Disease Transmission in Public Health Education Using a Geospatial Curriculum Approach by Rajika Emily Reed and Alec Bodzin in Pedagogy in Health Promotion
Uniting the DIFferences with The DALIA Interchange Format (DIF) – a Minimal Metadata Specification for the DALIA OER Platform
Creators: name: Geiger, Jonathan D.
name: Steiner, Petra
name: Desouki, Abdelmoneim Amer
name: Hüppe, Henrika Maria
name: Lange, Frank
name: Herres-Pawlis, Sonja
name: Kuntz, Alessandra
name: Sax, Ulrich
name: Ortmeyer, Jochen
Publisher: name: Zenodo
Year: 2025
Subjects: DALIA project
Open Educational Resources
OER
Learning resources
Learning material
Webplattform
Nationale Forschungsdateninfrastruktur
NFDI
Education
data literacy
Poster
Metadata schema
Sammlung
Community-Building
Metadaten

description: Teaching data literacy is essential for various areas of society such as politics, science and education. A systematic approach to promoting data literacy involves indexing, linking and making accessible digital teaching and learning resources. The DALIA project (“Data Literacy Alliance”), launched at the end of 2022, aims to link existing material and make it available in an accessible form. It is supported by various institutions and is closely linked to the National Research Data Infrastructure (NFDI). DALIA is developing a knowledge graph for networking and quality assurance of the materials. The DALIA Interchange Format (DIF) is used to schematize the metadata in order to ensure transparency and interoperability. It was created in collaboration with the community and takes existing data standards into account. The DIF V1.3 comprises 18 attributes, some of which are mandatory, others recommended or optional. The poster introduces the DALIA project and the DIF and invites further collaboration.
description: DALIA is currently funded by the Federal Ministry of Education and Research (BMBF) and the funding measure from the EU’s Capacity Building and Resilience Facility under the funding code 16DWWQP07.
Violence and Grief in Ahmed Saadawi’s Frankenstein in Baghdad
Creators: name: Raheem, Lailan
Publisher: name: TU Dortmund
Year: 2024
Subjects: subject: 700

description: This thesis examines the portrayal of violence and grief in Ahmed Sa’adawi’s Frankenstein in Baghdad (2013) and explores their implications in post-invasion Iraq. Tracing Iraq’s history throughout the past four decades shows that one cannot skip the topics of war, death, and loss. Thus, this novel reflects a broader trend among Iraqi authors who use literature to give a voice to the silenced and forgotten victims of war. Sa’adawi’s work, blending elements of horror, magical realism, and political satire, stands out as one of the few Iraqi works that successfully reached Western audiences and received international acclaim, partly because of its intriguing title, which evokes Mary Shelley’s Frankenstein. Sa’adawi’s Frankensteinian figure is a stitched-up corpse that becomes inhabited by a lost soul. Driven by vengeance on behalf of the previous owners of his body parts, he commits a series of crimes that stir the media. These events take place two years after the American invasion, during the onset of a brutal sectarian war. This research investigates how this figure and other characters, such as Hadi and Elishva, navigate grief and violence and the extent to which the “Whatsitname” or Shisma is a manifestation of collective grief, especially within the historical context of Iraq. In addition, it offers a transcultural analysis that makes use of historical, political, literary, and cultural theoretical perspectives to examine the interconnection between grief and violence by drawing on theories by Judith Butler, Giorgio Agamben, and Achille Mbembe, and others. For instance, Butler’s concepts of grievability and precariousness will be applied to examine which lives are deemed mournable in the context of war. Agamben’s notion of “bare life” will frame the analysis of characters existing in a state of exception, while Mbembe’s work on necropolitics will contextualise the pervasive conflict in Iraq. This theoretical background will be enhanced by incorporating secondary literature, which will provide additional depth to the analysis. This comprehensive study aims to contribute to the understanding of contemporary Iraqi literature and its role in highlighting the aftermath of prolonged conflict, while also engaging with broader theoretical discussions on grief and violence in post-colonial contexts. The research also seeks to shed light on the cyclical nature of violence portrayed in the novel and its influence in shaping the socio-political reality after several years of conflict.
Online_Appendix - A Question of Costliness: Time Horizons and Interstate Signaling
Creators: name: Haynes, Kyle
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 220104 Human Rights and Justice Issues
subject: FOS: Philosophy, ethics and religion
subject: 160607 International Relations
subject: FOS: Political science

description: Online_Appendix for A Question of Costliness: Time Horizons and Interstate Signaling by Kyle Haynes in Journal of Conflict Resolution
Skeletal Muscle Microvascular Blood Flow as a Potential Treatment Target for Exercise Intolerance in Patients with Peripheral Arterial Disease
Creators: name: Meneses, Annelise L
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2020
Subjects: Peripheral arterial disease
skeletal muscle
microcirculation
reactive hyperaemia
exercise
contrast-enhanced ultrasound

description: Peripheral arterial disease (PAD) is an atherosclerotic disease characterised by stenosis or occlusion of the arteries supplying the lower limbs. PAD is associated with severe exercise intolerance, which cannot be fully explained by the limitation in conduit artery blood flow. PAD also leads to chronic changes in the skeletal muscle phenotype, including alterations in skeletal muscle capillary density and ultrastructure, which are positively related to exercise intolerance. However, the extent to which calf muscle microvascular blood flow (i.e. perfusion) is affected by PAD is largely unknown. Using contrast-enhanced ultrasound (CEU), studies have shown a reduction in peak muscle perfusion capacity in response to ischemic provocation tests, such as thigh cuff occlusion and pain-limiting leg exercise in PAD compared with control participants. However, these studies were generally limited by the fact that they did not match PAD and control participants for age, and have not considered whole-leg or conduit artery blood flow responses when interpreting muscle microvascular responses to ischaemic provocation tests, such as cuff occlusion or exercise. Because age differences between groups may potentially bias the disease-related differences in muscle perfusion, this thesis first investigated the effect of age (Study One) and then, the effect of PAD (Study Two) on skeletal muscle microvascular perfusion responses to cuff occlusion and steady-state submaximal leg exercise using CEU. To further explore the influence of macrovascular (whole-limb) blood on muscle microvascular perfusion, this thesis investigated the effect of restored conduit artery flow, through lower-limb revascularisation, on microvascular perfusion in patients with PAD (Study Three). Last, a systematic review (Study Four) of the adjunct benefits of exercise therapy following revascularisation in patients with PAD was conducted. This review aimed to clarify whether the effect of this combined therapy approach, which has the potential to induce microvascular adaptations, is superior to revascularisation or exercise training alone.
Supplementary_data_(1) - Top cited articles on ameloblastoma: A bibliometric analysis
Creators: name: Shailesh M Gondivkar
name: Sarode, Sachin C
name: Amol R Gadbail
name: Gondivkar, Rima S
name: Gargi S Sarode
name: Nilookumari Choudhary
name: Shankargouda Patil
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine
subject: Medicine
subject: 111099 Nursing not elsewhere classified
subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: 111702 Aged Health Care
subject: 110323 Surgery

description: Supplementary_data_(1) for Top cited articles on ameloblastoma: A bibliometric analysis by Shailesh M Gondivkar, Sachin C Sarode, Amol R Gadbail, Rima S Gondivkar, Gargi S Sarode, Nilookumari Choudhary, and Shankargouda Patil in Translational Research in Oral Oncology
Influence of Age on the Cerebrovascular Responses to Exercise - Understanding the role of blood pressure
Creators: name: Klein, Timo
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2020
Subjects: cerebral blood flow
ageing
cerebrovascular health
cerebral autoregulation
tilt

description: Ageing and age-related cerebrovascular and neurodegenerative diseases, such as stroke and dementia, are associated with a reduction in cerebral blood flow and cerebrovascular function. Exercise is protective against these negative effects of ageing, where an increase in shear stress on the arterial wall, through increased blood flow, is the likely stimulus for enhanced vascular function. Blood pressure plays an important role in contributing to increases in cerebral blood flow. Older adults show a lower increase in cerebral blood flow during exercise, despite a higher increase in blood pressure, compared to younger adults. This suggests a lack of cerebral blood flow responsiveness with changes in arterial blood pressure in older adults. To understand and maximise the cerebral blood flow response to exercise in older adults, the initial aim of this thesis was to investigate the effect of age on cerebrovascular responses during interval and continuous exercise. Furthermore, this thesis aimed to better understand how the cerebral blood flow – blood pressure relationship is affected by age in response to dynamic stimuli. Three experimental studies were conducted to address these objectives.
BurknerOpenPracticesDisclosure – Supplemental material for Ordinal Regression Models in Psychology: A Tutorial
Creators: name: Paul-Christian Bürkner
name: Vuorre, Matti
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine

description: Supplemental material, BurknerOpenPracticesDisclosure for Ordinal Regression Models in Psychology: A Tutorial by Paul-Christian Bürkner and Matti Vuorre in Advances in Methods and Practices in Psychological Science
title: Éthique, politique, religions Les transformations du concept de guerre (1910-1930). 2016 - 2, n° 9
title: I. Limites et extension
titleType: Subtitle
Creators: name: (:Unap)
Publisher: name: Classiques Garnier
Year: 2016
Subjects: subject: Guerre totale
subject: Guerre civile mondiale
subject: Pacifisme
subject: Droit international
subject: Droit social
subject: Pensée juridique
subject: Socialisme juridique
subject: Lutte des classes
subject: Mémoire collective
subject: Névrose de guerre

description: Contributeurs : Thomas Berns, Marie Goupy, Ninon Grangé, Carlos Miguel Herrera, Céline Jouin et Juliette Lafosse.
Supplementary-material-0150 – Supplemental material for The role of school-based health education in adolescent spiritual moral, social and cultural development
Creators: name: Chester, Kayleigh L
name: Klemera, Ellen
name: Magnusson, Josefine
name: Spencer, Neil H
name: Brooks, Fiona M
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: Education

description: Supplemental material, Supplementary-material-0150 for The role of school-based health education in adolescent spiritual moral, social and cultural development by Kayleigh L Chester, Ellen Klemera, Josefine Magnusson, Neil H Spencer and Fiona M Brooks in Health Education Journal
Supplemental Material, Online_appendix - Patient Perspectives on Advance Care Planning via a Patient Portal
Creators: name: Jordan, Sarah R.
name: Adreanne Brungardt
name: Phoutdavone Phimphasone-Brady
name: Lum, Hillary D.
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences
subject: 111702 Aged Health Care

description: Supplemental Material, Online_appendix for Patient Perspectives on Advance Care Planning via a Patient Portal by Sarah R. Jordan, Adreanne Brungardt, Phoutdavone Phimphasone-Brady, and Hillary D. Lum in American Journal of Hospice and Palliative Medicine®
EJT_830773_Supp_Mat_Online_Appendix – Supplemental material for Voted out: Regime type, elections and contributions to United Nations peacekeeping operations
Creators: name: Duursma, Allard
name: Gledhill, John
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 160607 International Relations
subject: FOS: Political science

description: Supplemental material, EJT_830773_Supp_Mat_Online_Appendix for Voted out: Regime type, elections and contributions to United Nations peacekeeping operations by Allard Duursma and John Gledhill in European Journal of International Relations
Capacity management under uncertain demand and distribution policies: the case of Indian vaccine supply chain
Creators: name: Dixit, Vijaya
name: Omar, Ashish
name: Tang, Ou
name: Verma, Priyanka
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: The present study investigates the cause-and-effect relationships between production capacity decisions and the choice of distribution policy aspects of managing an extensive vaccination programme. The Indian COVID-19 vaccine supply chain is taken as a case study, and Indian demographic data is utilised. A Monte Carlo Markov Chain (MCMC) model is developed to estimate time period-wise demand corresponding to each distribution policy. Furthermore, eight different capacity management models involving different capacity addition and transfer strategies for four different distribution policies are formulated. The trade-off between effectiveness and efficiency objectives, namely Vaccine Supply Chain total cost and service level, is investigated by comparing the Pareto frontiers of the proposed models. Furthermore, the models are compared based on capacity transfer cost, capacity addition cost, and variation in region-wise service level. The results reveal that organisations can simultaneously save significant costs and achieve higher service levels if they cautiously align their capacity management approach and the distribution policy on the demand front. Capacity management interventions at the national level result in more service levels and lower variation and costs than at the regional level.
Route to non-Abelian quantum turbulence in spinor Bose-Einstein condensates
Creators: name: Mawson, Thomas
name: Ruben, Gary
name: Simula, Tapio
Publisher: name: Swinburne
Year: 2024

description: We have studied computationally the collision dynamics of spin-2 Bose-Einstein condensates initially confined in a triple-well trap. Depending on the phase structure of the initial-state spinor wave function, the collision of the three condensate fragments produces one of many possible vortex-antivortex lattices, after which the system transitions to quantum turbulence. We find that the emerging vortex lattice structures can be described in terms of multiwave interference. We show that the three-fragment collisions can be used to systematically produce staggered vortex-antivortex honeycomb lattices of fractional-charge vortices, whose collision dynamics are known to be non-Abelian. Such condensate collider experiments could potentially be used as a controllable pathway to generating non-Abelian superfluid turbulence with networks of vortex rungs.
World Harbour Project: Conflict and the Future in the World’s Harbours
Creators: name: Pearson, SG
name: Alexander, K
name: Brewer, T
Publisher: name: UNSW Sydney
Year: 2017

description: World Harbour Project: Conflict and the Future in the World’s Harbours Pearson, Stuart*1, Karen Alexander2 and Tom Brewer3 1 School of Physical, Environmental and Mathematical Sciences, UNSW Canberra, ACT 2600, Australia 2 Centre for Marine Socioecology, Institute for Marine and Antarctic Studies, Hobart, TAS 7000 3 Northern Institute, Arafura Timor Research Facility, Charles Darwin University, Darwin, NT 0909 stuart.pearson@unsw.edu.au As a result of residential and industrial development, harbours are often subject to elevated loads of pollutants from various shipping activities, industrial spills and leaks, sewage outfall and agricultural waste (amongst other sources). Managing conflict in harbours, the most intensely altered part of the littoral zone, has been a successful focus of an international collaboration. This paper will share key findings from the 2016 paper Conflicts in some of the World Harbours: what needs to happen next? Conflicts appear clearly in rapid developing harbours when values or uses of harbours are changing (Jakarta Bay, Jiaozhou Bay) and can become latent in other situations (Sydney, Plymouth). Yet we suspect there is remarkable agreement if the timeframes were extended out into the future – say 10 years. Likewise looking back from 20 years hence gets users engaged in avoiding undesirable futures and making decisions now to increase the chance of achieving plausible and desirable future states. Decisions, valuations and risk are framed by views of the future and so it is prudent to examine how these are developed in harbour users. Futures are important and useful discussions in conflictual environments because they help lift people into more creative solution spaces. In the World Harbour Project Working Group 3 the future was seen as a useful place to make a contribution for discovering shared and sharable insights into the ways harbour conflicts could be discussed and resolved. An initial paper shows that the ways conflicts are managed is sometimes framed by a deep embodiment of cultural and biophysical constraints. The future is a discussion that relaxes some of those constraints while imposing a long-term and collaborative perspective. Our research is currently mapping the activity in futures thinking in Ports and Harbours.
description: Australian Marine Sciences Association - Connections through Shallow Seas; Darwin NT; 2017-07-02 - 2017-07-06
การจัดการท่องเที่ยวเชิงสร้างสรรค์บนฐานทุนวัฒนธรรมชุมชนเมืองโบราณเวียงลอ ตำบลลอ อำเภอจุน จังหวัดพะเยา
Creators: name: วรัญญา พรหมสาขา ณ สกลนคร
Publisher: name: คณะมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยราชภัฏบุรีรัมย์
Year: 2567
Subjects: ทุนวัฒนธรรม
การท่องเที่ยวเชิงสร้างสรรค์
เมืองโบราณเวียงลอ

description: มนุษยสังคมสาร (มสส.), 22, 2, 61-80
Development and application of systems biology approaches for multiple dimensional data integration on cancer genomics data
Creators: name: Wee, Yong Kiat
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2021
Subjects: cancer genomics

description: Cancer is a genetic disorder classified by the accumulation of somatic cellular aberrations. During the last decade, many different techniques have been developed to comprehensively characterise these changes in cancer cells. Both large-scale and focused efforts using various bioinformatics tools have identified new targets in translational clinical research. These approaches have become an important component of the drug discovery and development of personalized medicine for the future. Thus, the complication of somatic genomic alterations in cancer genomes requires the development of robust computational framework and methods for the investigation of the biological function of genes. The aim of this study was to develop bioinformatics framework to perform an integrated analysis of large-scale cancer genomics data, as well as to demonstrate the applicability of these approaches in targeted cancer treatment research.
Deciphering the origin of spin current in spintronic terahertz emitters and its imprint on their electromagnetic radiation via time-dependent density functional theory
Creators: name: Kefayati, Ali
name: Ren, Yafei
name: Jungfleisch, M. Benjamin
name: Gundlach, Lars
name: Xiao, John Q.
name: Nikolic, Branislav K.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Spin current flowing between femtosecond laser pulse (fsLP)-driven ferromagnetic metal and adjacent normal metal (NM) hosting strong spin-orbit coupling is invariably invoked to explain terahertz (THz) radiation believed to be emitted solely by NM layer. Despite being such a central concept, the microscopic origin of interlayer spin current remains vague. Here, we employ recently developed [A. Kefayati {\em et al.}, Phys. Rev. Lett. {\bf 133}, 136704 (2024)] time-dependent density functional theory plus Jefimenko equations approach to extract spin current between Co and NM=Pt or NM=W layer where Co is driven by fsLP responsible for its demagnetization, i.e., shrinking of its magnetization vector, $M^y(t)/M^y(t=0)<1$. By comparing time dependence of spin current with those of other relevant quantities, we find that: ({\em i}) spin current is generated by demagnetization dynamics because it {\em follows} closely $dM^y/dt$, thus it is an example of quantum pumping phenomenon that cannot be captured by phenomenological notions (such as ``spin voltage'') and related semiclassical transport theories; ({\em ii}) time dependence of pumped spin current {\em does not follow} closely that of charge current emerging within NM layer via spin-to-charge conversion mechanisms; ({\em iii}) THz emission can be governed by {\em both} charge current (i.e., its time derivative entering the Jefimenko equations) within Co layer or NM layer, but in different times frames. We also unravel a special case of NM=W where spin-to-charge conversion by the inverse spin Hall effect and its contribution to THz emission is suppressed, despite large spin Hall angle of W, because of localization of excited electrons onto the outer unfilled $d$-orbitals of W.
description: 9 pages, 3 figures, 90 references
Impacts of 4WD vehicles on K’gari roads: towards a sustainable transport solution
Creators: name: Waldron, Ross
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2023
Subjects: erosion
sustainability
road
K'gari
world heritage
park management
sand roads
Environmental management
Soil sciences

description: Increasing tourism in recent decades to the World Heritage listed K’gari (Fraser Island) has presented challenges for park management in terms of visitor impacts to popular visitor sites and erosion of the inland four-wheel-drive (4WD) tracks. This thesis focusses on sustainable transport strategies and solutions for K’gari (Fraser Island). Tourism values and patterns for the region are reviewed with recent vehicle-use permit numbers for K’gari included. This thesis also contains a brief history of the development of the transport network and a description of the current transport network on K’gari (Fraser Island). It further includes an explanation of the erosive processes involved on the 4WD tracks. The current impacts occurring on the inland transport network are investigated and the how, why, and where these impacts occur is explored, as is the historical and contemporary observation of 4WD vehicle erosional impacts on the inland tracks. In fieldwork on nearby Cooloola, changes in the road surface level, along with other environmental variables, are measured over time. Importantly, a series of strategies and solutions to reduce 4WD impacts on the island and enhance road monitoring, restoration and maintenance are presented. Solutions are presented ranging from adaptation strategies, strategic planning, monitoring, and funding solutions based on global best practices. Road surface profiles from fieldwork sites on Cooloola and K’gari (Fraser Island) are utilised in a WEPP prediction model to estimate annual runoff and sediment erosion from 2021 to 2030. An estimate for the sustainable capacity of visitor vehicles at any one time for K’gari (Fraser Island) and a moderated strategy that does not significantly affect most stakeholders is recommended. Management challenges, global applications and future research possibilities are examined, including a discussion on the barriers to effective implementation of the strategies and solutions presented for sustainable transport on K’gari (Fraser Island).
Advances in hydrodynamic modelling of flow in rivers and estuaries using Lagrangian drifter data
Creators: name: Mardani, Neda
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2021
Subjects: Hydrodynamic modelling
data assimilation
Lagrangian data
Estuary
Eulerian instruments
Model calibration
Rating curve
Fluid dynamics
OSSE
Twin experiment
Observation locations
Open-source tool

description: The major environmental challenges to society, for example, climate change, environmental degradation and the extreme weather effects, require comprehensive information for a resourceful response, including informed decision making related to future actions. Estuaries are especially exposed to the footprints of climate change because alterations in climatic variables that impact freshwater and marine systems will also influence estuaries. While this knowledge is useful, scientists currently lack detailed information on the impact of global change in a diverse range of morphological estuary types across continental and global regions (Scanes et al., 2020). By identifying the processes and attributes responsible for estuary change, the dynamics of estuaries is more accurately predictable around the globe. However, to achieve this goal, two remaining components are needed: (1) a tool for collecting information; and (2) a robust method to elaborate this information. In other words, observations (measurements) support the first component, and the latter component is provided by models. The mechanisms to secure these two avenues of investigation are distinct: observations are directly connected with the system under investigation through measurement devices, while models have an indirect connection with the system, being an expression of measurements and represent an abstraction of reality. To make use of the information incorporated in observations and models, it is essential to understand the characteristics of this information. In particular, the errors and limitations associated with both observations and models. Errors in models are generated through incomplete implementation of the model as well as their imperfect simulation of real world processes. Another basic attribute of observations is that they are spatially and temporally discrete, which results in gaps in the information provided by them. To fill these gaps, it is important to first make observations more complete, with better spatial coverage, and hence more useful; secondly, use observation on the behaviour of the system to extend the observations for the purpose of reflecting the reality (e.g., using a model) (W. Lahoz et al., 2010). The model can then propagate the information from observations and better represent the real state of the system under investigation. The idea behind choosing a model for a particular environment is that the model provides a set of consistent principles which when registered, makes the most efficient use of observations.
Table_S5 – Supplemental material for Persistent Cannabis Dependence and Alcohol Dependence Represent Risks for Midlife Economic and Social Problems
Creators: name: Cerdá, Magdalena
name: Moffitt, Terrie E.
name: Meier, Madeline H.
name: HonaLee Harrington
name: Houts, Renate
name: Ramrakha, Sandhya
name: Hogan, Sean
name: Poulton, Richie
name: Caspi, Avshalom
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, Table_S5 for Persistent Cannabis Dependence and Alcohol Dependence Represent Risks for Midlife Economic and Social Problems by Magdalena Cerdá, Terrie E. Moffitt, Madeline H. Meier, HonaLee Harrington, Renate Houts, Sandhya Ramrakha, Sean Hogan, Richie Poulton and Avshalom Caspi in Clinical Psychological Science
Supplement_1_-_June_8_-_JCMS – Supplemental material for Satisfaction and Awareness of Systemic Psoriasis Treatments: A National Survey Comparing Biologic and Nonbiologic Users
Creators: name: Ighani, Arvin
name: Yu, Ashley M.
name: Sandhu, Vijay K.
name: Barankin, Benjamin
name: Manolson, Morris F.
Publisher: name: SAGE Journals
Year: 2019
Subjects: Medicine

description: Supplemental material, Supplement_1_-_June_8_-_JCMS for Satisfaction and Awareness of Systemic Psoriasis Treatments: A National Survey Comparing Biologic and Nonbiologic Users by Arvin Ighani, Ashley M. Yu, Vijay K. Sandhu, Benjamin Barankin and Morris F. Manolson in Journal of Cutaneous Medicine and Surgery
Additional file 2 of Decision makers perceptions and experiences of developing population-level interventions targeting risk factors for hypertension and diabetes in South Africa: a qualitative study
Creators: name: Hendricks, Lynn
name: Uwimana-Nicol, Jeannine
name: Young, Taryn
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biological Sciences not elsewhere classified
Science Policy

description: Additional file 2. Interview guide for stakeholders.
Additional file 3 of Decision makers perceptions and experiences of developing population-level interventions targeting risk factors for hypertension and diabetes in South Africa: a qualitative study
Creators: name: Hendricks, Lynn
name: Uwimana-Nicol, Jeannine
name: Young, Taryn
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biological Sciences not elsewhere classified
Science Policy

description: Additional file 3. Illustrative quotes of enablers.
Understanding the influence of lower limb revascularisation and exercise training on arterial and microvascular blood flow in peripheral arterial disease
Creators: name: Krastins, Digby
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2021
Subjects: peripheral arterial disease
microcirculation
blood flow
exercise
exercise training
contrast-enhanced ultrasound

description: Peripheral arterial disease (PAD) is an atherosclerotic disease characterised by decreased leg blood flow and decreased exercise capacity. Low conduit artery blood flow is often assumed to be the primary cause of the decreased exercise capacity. However, low leg blood flow alone does not fully explain the decreased exercise capacity. PAD also leads to reduced muscle microvascular blood flow capacity, although the extent to which muscle microvascular blood flow contributes to the reduced exercise capacity is unknown. Therefore, the relative contributions of leg blood flow and muscle microvascular blood flow to the decreased exercise capacity of patients with PAD were investigated in this thesis.
BlampiedFigS6 – Supplemental material for Effect of Micronutrients on Insomnia in Adults
Creators: name: Lothian, Joanna
name: Blampied, Neville M.
name: Rucklidge, Julia J.
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, BlampiedFigS6 for Effect of Micronutrients on Insomnia in Adults by Joanna Lothian, Neville M. Blampied and Julia J. Rucklidge in Clinical Psychological Science
title: In vivo investigation of component-specific functions of the Hippo pathway
Creators: name: Riley, Susanna Elizabeth
Publisher: name: The University of Edinburgh
Year: 2024
Subjects: subject: CRISPR
subject: zebrafish
subject: Hippo pathway

description: The Hippo pathway is a kinase signalling cascade involved in the regulation of organ size, tissue homeostasis, and stem cell proliferation. Dysfunction of this pathway is associated with carcinogenesis, fibrosis, and defects in development and regeneration. The key effectors of the Hippo pathway are YAP and TAZ, which translocate to the nucleus, bind to transcription factors, and induce transcription when Hippo signalling is off. The wide-ranging role of the Hippo pathway means that it must be strictly regulated, and so context-dependent molecular understanding is needed for it to be manipulated therapeutically. However, the function of individual components of the pathway is not well understood, and a direct comparison of the different roles of Hippo pathway components has so far mainly been carried out in vitro. To study these functions in vivo, a range of zebrafish Hippo pathway CRISPR mutants (CRISPants) were generated and analysed as part of a medium-throughput screen to identify regenerative and developmental phenotypes. Many developmental phenotypes were identified and quantified that match those reported in previous publications, as well as multiple novel findings. Neuromast and tail fin regeneration phenotypes were also identified. Notable phenotypes include differences between yap1 and wwtr1 CRISPants, and a selective reduction in severe tail fin regeneration in wwtr1 CRISPants but no consistent phenotype in any other developmental or regenerative parameter. Preliminary analysis of molecular and cellular drivers of this tail fin regeneration was performed, including the analysis of RNAseq data, immunofluorescence labelling of both proteins and mRNA, and live imaging of multiple transgenic lines after tail fin injury. These enabled a separation of yap1 and wwtr1 CRISPant phenotypes at a molecular and cellular level. The generation and characterisation of a ctgfa:GFP reporter transgenic line and Yap1 and Taz stable mutant lines are also reported. Overall, the project provides insights into Hippo component-specific regulation of development and regeneration in both teleosts and mammals.
Additional file 1 of Detection and sequence analysis of Canine morbillivirus in multiple species of the Mustelidae family
Creators: name: Lanszki, Zsófia
name: Lanszki, József
name: Tóth, Gábor Endre
name: Cserkész, Tamás
name: Csorba, Gábor
name: Görföl, Tamás
name: Csathó, András István
name: Jakab, Ferenc
name: Kemenesi, Gábor
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology

description: Additional file 1.
Shadows and parameter estimation of rotating quantum corrected black holes and constraints from EHT observation of M87* and Sgr A*
Creators: name: Ali, Heena
name: Islam, Shafqat Ul
name: Ghosh, Sushant G.
Publisher: name: arXiv
Year: 2024
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The scarcity of quantum gravity (QG) inspired rotating black holes limits the progress of testing QG through Event Horizon Telescope (EHT) observations. The EHT imaged the supermassive black holes, Sgr A* and M87*, revealing an angular shadow diameter of $d_{sh} = 48.7 \pm 7 μ$as with a black hole mass of $M = 4.0_{-0.6}^{+1.1} \times 10^6 M\odot$ for Sgr A*. For M87*, with a mass of $M = (6.5 \pm 0.7) \times 10^9 M_\odot$, the EHT measured an angular diameter of $θ_d = 42 \pm 3 μ$as. We present rotating quantum-corrected black hole (RQCBH) spacetimes with an additional QC parameter $α$ and constrain it by EHT observations. For angular shadow diameter ($d_{sh}$) of Sgr A* at $θ_o = 50^0$, the bounds are $0.0 \leq α\leq 1.443 M^2$ and $a \in (0, 0.8066 M)$. For $θ_o = 90^0$, the bounds are $0.0 \leq α\leq 1.447 M^2$ and $a \in (0, 0.894 M)$. While for M87* at inclination $θ_o = 17^0$, the bounds are $a \in (0, 0.8511 M)$ at $α=0$ and $a \in (0, 0.6157 M)$ at $α=0.8985 M^2$. For $θ_o = 90^0$, the bounds are $a \in (0, 0.8262 M)$ at $α=0$ and $a \in (0, 0.9799 M)$ at $α=0.4141 M^2$. These results show that $α$ significantly affects the shadows, offering key constraints on QG models. With EHT constraints from Sgr A and M87*, RQCBHs and Kerr black holes are indistinguishable in much of the EHT-constrained parameter space, making RQCBHs strong candidates for astrophysical black holes along with other BHs, e.g., regular black holes and other quantum-corrected solutions.
description: 27 Pages, 15 Figures, 4 Tables
Additional file 4 of Decision makers perceptions and experiences of developing population-level interventions targeting risk factors for hypertension and diabetes in South Africa: a qualitative study
Creators: name: Hendricks, Lynn
name: Uwimana-Nicol, Jeannine
name: Young, Taryn
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biological Sciences not elsewhere classified
Science Policy

description: Additional file 4. Illustrative quotes of challenges.
Cognitive Function and The Risk of Dementia: The Influence of Physical Fitness and Exercise in Older Adults
Creators: name: Stuckenschneider, Tim
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2020
Subjects: Mild cognitive impairment
Parkinson's disease
cognition
exercise
fitness

description: Cognitive impairment is one of the most common health problems among older adults and has become a major focus for healthcare providers due to the ageing of the global population (1). The prevalence of cognitive impairment has been estimated to be around 7% among older adults aged between 60 and 65 years (2, 3), and is reported to increase to about 40% among older adults aged 80 years and over (3, 4). Moreover, the most common mental and neurological disorders among older adults, which are Alzheimer’s disease (AD) and Parkinson’s disease (PD), are either defined by or associated with cognitive impairment. Cognitive impairment describes a continuum of signs ranging from subjective cognitive impairment (SCI) to mild cognitive impairment (MCI) and dementia (3, 5-7). No cure for dementia currently exists, prompting increased efforts to understand the preclinical stages such as SCI and MCI as potential opportunities for new interventions (3, 5-7). The current guidelines of the American Academy of Neurology (AAN) promote regular exercise for these individuals (3). However, only two studies underpin this recommendation of the AAN, and there is a clear need for studies with larger sample sizes, standardised neuropsychological testing methods, longer intervention periods and well-defined diagnostic criteria for MCI (3). A primary prevention strategy that delays the conversion to dementia by even two years would greatly reduce the total number of patients living with dementia, and result in important public health, economic and societal benefits (8-10). Therefore, this thesis explored the effects of exercise on cognition in individuals at high risk for dementia to determine if targeted exercise presents an optimal primary prevention strategy. In particular, this thesis focused on different modes of exercise, while also evaluating methods to monitor exercise intensity and physical activity. In addition, this thesis investigated the efficacy of electroencephalography (EEG) markers for cognitive decline in older adults.
Supplemental material for Theoretical and experimental investigation on controlled synchronization of four co-rotating coupled exciters driven by induction motors in a vibrating system
Creators: name: Dawei Gu
name: Juqian Zhang
name: Bangchun Wen
name: Xueliang Zhang
name: Yunshan Liu
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies

description: Supplemental Material for Theoretical and experimental investigation on controlled synchronization of four co-rotating coupled exciters driven by induction motors in a vibrating system by Dawei Gu, Juqian Zhang, Bangchun Wen, Xueliang Zhang and Yunshan Liu in Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science
Revision_Supplementary_Figure_-_The_Prevalence_of_BMI_Associated_Chronic_Diseases_in_Diverse_Ethnic_Groups_in_New_Zealand – Supplemental material for The Prevalence of Body Mass Index–Associated Chronic Diseases in Diverse Ethnic Groups in New Zealand
Creators: name: Halim, Andrew Adiguna
name: Arindam Basu
name: Kirk, Ray
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, Revision_Supplementary_Figure_-_The_Prevalence_of_BMI_Associated_Chronic_Diseases_in_Diverse_Ethnic_Groups_in_New_Zealand for The Prevalence of Body Mass Index–Associated Chronic Diseases in Diverse Ethnic Groups in New Zealand by Andrew Adiguna Halim, Arindam Basu and Ray Kirk in Asia Pacific Journal of Public Health
title: Evaluating the consistency of ensemble forecasts
Creators: name: Richardson, David Shaw
Publisher: name: University of Reading
Year: 2025

description: Ensemble forecasts play an essential role in providing early warnings to mitigate the impact of 
hazardous weather events. However, there are still many areas where ensemble information is 
not fully exploited. One key issue limiting the uptake of ensemble forecasts is the jumpiness that 
can sometimes occur between successive forecasts. Ensemble forecasts show the range of 
future weather scenarios that can occur, allowing users to make appropriate risk-based 
decisions. Occasionally a new forecast seems to contradict the previous forecast by introducing 
a new weather scenario that was not represented in the previous ensemble. Such 
inconsistencies can cause users to lose confidence in the forecasting system. 
This thesis aims to improve the diagnosis and understanding of these ensemble forecast 
inconsistencies. First, a methodology is developed to quantify the consistency between a 
sequence of ensemble forecasts valid for a given time, taking account of the full ensemble 
distribution. This enables a quantitative evaluation of the consistency or jumpiness between 
successive forecasts, providing insights into the relationship between jumpiness, skill and 
spread.
The thesis also provides practical guidance to address user concerns about ensemble jumpiness. 
It provides specific guidance that will enable users to make better use of the available 
operational ensemble tropical cyclone track and genesis forecasts. The thesis shows that 
evaluation of forecast consistency is complementary to the current focus on skill and ensemble 
spread, and that an integrated approach using both skill and consistency measures can be 
beneficial in evaluation of ensemble forecast performance.
Implementation of this approach at NWP centres will ensure that users have the necessary 
information and guidance to mitigate the impact of run-to-run jumpiness and will provide 
feedback to model developers on model weaknesses, complementing existing evaluation tools. 
The research in this thesis will help improve the utilisation of ensemble forecasts to provide 
early warnings of significant weather hazards, contributing to the UN Early Warnings for All 
initiative.
Additional file 1 of Metabolic engineering of Rhodotorula toruloides for resveratrol production
Creators: name: Zhang, Mengyao
name: Gao, Qidou
name: Liu, Yijuan
name: Fang, Zhumei
name: Gong, Zhiwei
name: Zhao, Zongbao K.
name: Yang, Xiaobing
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Plant Biology

description: Additional file 1: Table S1. Strain and plasmids used in this work. Table S2. Main primers used in this work. Table S3. The highest resveratrol yield among the different hosts and their engineering strategies. Figure S1. Validation of resveratrol production in engineered strain by LCMS. The characteristic peaks of the resveratrol standard are at m/z=227.0714 and m/z=228.0751, and that of fermentation extracts from engineered strain is at m/z=227.0716 and m/z=228.0749, which is highly consistent within the standard. Figure S2. Multiple pairwise sequence alignment between S. cerevisiae, Y. lipolytica and R. toruloides Aro4p and Aro7p. Multiple pairwise alignments of Aro4p; In ScAro4p, the 229th amino acid resulted in a feedback insensitivity when lysine mutated into leucine (Hartmann et al., 2003), and the 211th amino acid in YlAro4p has the same mutation (Palmer et al., 2020), which are marked with red arrows. For Aro7p, In ScAro7p, amino acid 141 resulted in a non-allosterically regulated when glycine mutated into serine (Schnappauf et al., 1998), and the 139th amino acid in YlAro7p has the same mutation (Sáez-Sáez et al., 2020) which are marked with red arrows. Figure S3. Fluorescence microscopy analysis of lipids in engineered R. toruloides stained with Nile Red. Scale bars, 20 μM.