cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Re-assessment of monoclonal antibodies against diclofenac for their application in the analysis of environmental waters
Creators: name: Schmidt, Stephan
name: Hoffmann, Holger
name: Garbe, Leif-Alexander
name: Harrer, Andrea
name: Steiner, Markus
name: Himly, Martin
name: Schneider, Rudolf J.
Publisher: name: Humboldt-Universität zu Berlin
Year: 2024
Subjects: subject: 540 Chemie und zugeordnete Wissenschaften

description: The non-steroidal anti-inflammatory drug (NSAID) diclofenac (DCF) is an important environmental contaminant occurring in surface waters all over the world, because, after excretion, it is not adequately removed from wastewater in sewage treatment plants. To be able to monitor this pollutant, highly efficient analytical methods are needed, including immunoassays. In a medical research project, monoclonal antibodies against diclofenac and its metabolites had been produced. Based on this monoclonal anti-DCF antibody, a new indirect competitive enzyme-linked immunosorbent assay (ELISA) was developed and applied for environmental samples. The introduction of a spacer between diclofenac and the carrier protein in the coating conjugate led to higher sensitivity. With a test midpoint of 3 μg L−1 and a measurement range of 1–30 μg L−1, the system is not sensitive enough for direct analysis of surface water. However, this assay is quite robust against matrix influences and can be used for wastewater. Without adjustment of the calibration, organic solvents up to 5%, natural organic matter (NOM) up to 10 mg L−1, humic acids up to 2.5 mg L−1, and salt concentrations up to 6 g L−1 NaCl and 75 mg L−1 CaCl2 are tolerated. The antibody is also stable in a pH range from 3 to 12. Cross-reactivity (CR) of 1% or less was determined for the metabolites 4′-hydroxydiclofenac (4′-OH-DCF), 5-hydroxydiclofenac (5-OH-DCF), DCF lactam, and other NSAIDs. Relevant cross-reactivity occurred only with an amide derivative of DCF, 6-aminohexanoic acid (DCF-Ahx), aceclofenac (ACF) and DCF methyl ester (DCF-Me) with 150%, 61% and 44%, respectively. These substances, however, have not been found in samples. Only DCF-acyl glucuronide with a cross-reactivity of 57% is of some relevance. For the first time, photodegradation products were tested for cross-reactivity. With the ELISA based on this antibody, water samples were analysed. In sewage treatment plant effluents, concentrations in the range of 1.9–5.2 μg L−1 were determined directly, with recoveries compared to HPLC-MS/MS averaging 136%. Concentrations in lakes ranged from 3 to 4.4 ng L−1 and were, after pre-concentration, determined with an average recovery of 100%.
Notodromadidae Kaufmann 1900
Creators: name: Meisch, Claude
name: Smith, Robin J.
name: Martens, Koen
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Notodromadidae

description: Family Notodromadidae Kaufmann, 1900
Subfamily Cyproidinae Hartmann, 1963
Cyprois Zenker, 1854
Subfamily Notodromadinae Kaufmann, 1900
Argentodromas Díaz & Martens, 2018
Centrocypris Vávra, 1895
Gurayacypris Battish, 1987
Kennethia De Deckker, 1979
Newnhamia King, 1855
Notodromas Lilljeborg, 1853
Subfamily Oncocypridinae De Deckker, 1979
Neozonocypris Klie, 1944
Oncocypris G.W. Müller, 1898
description: Published as part of Meisch, Claude, Smith, Robin J. & Martens, Koen, 2019, A subjective global checklist of the extant non-marine Ostracoda (Crustacea), pp. 1-135 in European Journal of Taxonomy 492 on page 21, DOI: 10.5852/ejt.2019.492, http://zenodo.org/record/3271099
Long-term observations of cloud condensation nuclei in the Amazon rain forest – Part 1: Aerosol size distribution, hygroscopicity, and new model parametrizations for CCN prediction
Creators: name: Pöhlker, Mira L.
name: Pöhlker, Christopher
name: Ditas, Florian
name: Klimach, Thomas
name: Hrabe De Angelis, Isabella
name: Araújo, Alessandro
name: Brito, Joel
name: Carbone, Samara
name: Cheng, Yafang
name: Chi, Xuguang
name: Ditz, Reiner
name: Gunthe, Sachin S.
name: Kesselmeier, Jürgen
name: Könemann, Tobias
name: Lavri?, Jošt V.
name: Martin, Scot T.
name: Mikhailov, Eugene
name: Moran-Zuloaga, Daniel
name: Rose, Diana
name: Saturno, Jorge
name: Su, Hang
name: Thalman, Ryan
name: Walter, David
name: Wang, Jian
name: Wolff, Stefan
name: Barbosa, H. M. J.
name: Artaxo, Paulo
name: Andreae, Meinrat O.
name: Pöschl, Ulrich
Publisher: name: EGU
Year: 2016

description: Size-resolved long-term measurements of atmospheric aerosol and cloud condensation nuclei (CCN) concentrations and hygroscopicity were conducted at the remote Amazon Tall Tower Observatory (ATTO) in the central Amazon Basin over a 1-year period and full seasonal cycle (March 2014–February 2015). The measurements provide a climatology of CCN properties characteristic of a remote central Amazonian rain forest site.The CCN measurements were continuously cycled through 10 levels of supersaturation (S = 0.11 to 1.10 %) and span the aerosol particle size range from 20 to 245 nm. The mean critical diameters of CCN activation range from 43 nm at S = 1.10 % to 172 nm at S = 0.11 %. The particle hygroscopicity exhibits a pronounced size dependence with lower values for the Aitken mode (?Ait = 0.14 ± 0.03), higher values for the accumulation mode (?Acc = 0.22 ± 0.05), and an overall mean value of ?mean = 0.17 ± 0.06, consistent with high fractions of organic aerosol.The hygroscopicity parameter, ?, exhibits remarkably little temporal variability: no pronounced diurnal cycles, only weak seasonal trends, and few short-term variations during long-range transport events. In contrast, the CCN number concentrations exhibit a pronounced seasonal cycle, tracking the pollution-related seasonality in total aerosol concentration. We find that the variability in the CCN concentrations in the central Amazon is mostly driven by aerosol particle number concentration and size distribution, while variations in aerosol hygroscopicity and chemical composition matter only during a few episodes.For modeling purposes, we compare different approaches of predicting CCN number concentration and present a novel parametrization, which allows accurate CCN predictions based on a small set of input data.
Cytheridae Baird 1850
Creators: name: Meisch, Claude
name: Smith, Robin J.
name: Martens, Koen
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Cytheridae

description: Family Cytheridae Baird, 1850
Pericythere Hartmann, 1957
Perissocytheridea Stephenson, 1938
description: Published as part of Meisch, Claude, Smith, Robin J. & Martens, Koen, 2019, A subjective global checklist of the extant non-marine Ostracoda (Crustacea), pp. 1-135 in European Journal of Taxonomy 492 on page 21, DOI: 10.5852/ejt.2019.492, http://zenodo.org/record/3271099
LALINET: The First Latin American–Born Regional Atmospheric Observational Network
Creators: name: Antuña-Marrero, Juan Carlos
name: Landulfo, Eduardo
name: Estevan, René
name: Barja, Boris
name: Robock, Alan
name: Wolfram, Elián
name: Ristori, Pablo
name: Clemesha, Barclay
name: Zaratti, Francesco
name: Forno, Ricardo
name: Armandillo, Errico
name: Bastidas, Álvaro E.
name: Baraja, Ángel M. De Frutos
name: Whiteman, David N.
name: Quel, Eduardo
name: Barbosa, H. M. J.
name: Lopes, Fabio
name: Montilla-Rosero, Elena
name: Guerrero-Rascado, Juan L.
Publisher: name: AMS
Year: 2017

description: Sustained and coordinated efforts of lidar teams in Latin America at the beginning of the twenty-first century have built the Latin American Lidar Network (LALINET), the only observational network in Latin America created by the agreement and commitment of Latin American scientists. They worked with limited funding but an abundance of enthusiasm and commitment toward their joint goal. Before LALINET, there were a few pioneering lidar stations operating in Latin America, described briefly here. Biannual Latin American lidar workshops, held from 2001 to the present, supported both the development of the regional lidar community and LALINET. At those meetings, lidar researchers from Latin America met to conduct regular scientific and technical exchanges among themselves and with experts from the rest of the world. Regional and international scientific cooperation has played an important role in the development of both the individual teams and the network. The current LALINET status and activities are described, emphasizing the processes of standardization of the measurements, methodologies, calibration protocols, and retrieval algorithms. Failures and successes achieved in the buildup of LALINET are presented. In addition, the first LALINET joint measurement campaign and a set of aerosol extinction profile measurements obtained from the aerosol plume produced by the Calbuco volcano eruption on 22 April 2015 are described and discussed.
MeerKAT to Mass Constraints: Optical Modelling of PSR J1910-5320
Creators: name: Dodge, Oliver
Publisher: name: Zenodo
Year: 2024

description: PSR J1910-5320 is a new millisecond pulsar discovered during the TRAPUM large survey project's survey of unidentified gamma-ray sources. The precise localisation obtained from the initial MeerKAT detection was found to be coincident with a new candidate redback binary system, independently discovered through its optical variability in the Catalina Sky Survey (CSS) catalogue, and confirmed via optical spectroscopy. Folding the CSS optical photometry with an initial MeerKAT timing ephemeris confirmed the association, revealing a typical spider pulsar light curve, with an optically bright companion being strongly irradiated by the newly-discovered millisecond pulsar. Spider binaries like PSR J1910-5320 are often seen to contain massive neutron stars, and so new spider mass measurements can provide important constraints on the neutron-star equation-of-state. These mass measurements are obtained by solving the binary mass function using estimates of three key parameters. The first, the orbital inclination angle, can be estimated from modelling of optical light curves, for which we obtained new multi-colour observations with ULTRACAM on ESO's New Technology Telescope. The second key, the companion's velocity, is found through optical spectroscopy. The MeerKAT timing solution provides the final puzzle piece - the pulsar's radial velocity, which constrains the binary mass ratio. I will describe new modifications to the Icarus binary light curve synthesis code that allow us to provide a general optical model for spider binaries, drawing from photometry and spectroscopy simultaneously and self-consistently, and explain how this process leads to a moderate neutron star mass estimate for PSR J1910-5320, and to refined assumptions about the irradiation and atmosphere in redback companion stars.
Amazon boundary layer aerosol concentration sustained by vertical transport during rainfall
Creators: name: Wang, Jian
name: Krejci, Radovan
name: Giangrande, Scott
name: Kuang, Chongai
name: Barbosa, H. M. J.
name: Brito, Joel
name: Carbone, Samara
name: Chi, Xuguang
name: Comstock, Jennifer
name: Ditas, Florian
name: Lavric, Jost
name: Manninen, Hanna E.
name: Mei, Fan
name: Moran-Zuloaga, Daniel
name: Pöhlker, Christopher
name: Pöhlker, Mira L.
name: Saturno, Jorge
name: Schmid, Beat
name: Souza, Rodrigo A. F.
name: Springston, Stephen R.
name: Tomlinson, Jason M.
name: Toto, Tami
name: Walter, David
name: Wimmer, Daniela
name: Smith, James N.
name: Kulmala, Markku
name: Machado, Luiz A. T.
name: Artaxo, Paulo
name: Andreae, Meinrat O.
name: Petäjä, Tuukka
name: Martin, Scot T.
Publisher: name: Maryland Shared Open Access Repository
Year: 2016
Subjects: Biogeochemistry
Atmospheric science
Environmental sciences

description: The nucleation of atmospheric vapours is an important source of new aerosol particles that can subsequently grow to form cloud condensation nuclei in the atmosphere1. Most field studies of atmospheric aerosols over continents are influenced by atmospheric vapours of anthropogenic origin (for example, ref. 2) and, in consequence, aerosol processes in pristine, terrestrial environments remain poorly understood. The Amazon rainforest is one of the few continental regions where aerosol particles and their precursors can be studied under near-natural conditions3,4,5, but the origin of small aerosol particles that grow into cloud condensation nuclei in the Amazon boundary layer remains unclear6,7,8. Here we present aircraft- and ground-based measurements under clean conditions during the wet season in the central Amazon basin. We find that high concentrations of small aerosol particles (with diameters of less than 50 nanometres) in the lower free troposphere are transported from the free troposphere into the boundary layer during precipitation events by strong convective downdrafts and weaker downward motions in the trailing stratiform region. This rapid vertical transport can help to maintain the population of particles in the pristine Amazon boundary layer, and may therefore influence cloud properties and climate under natural conditions.
Cytherideidae Sars 1925
Creators: name: Meisch, Claude
name: Smith, Robin J.
name: Martens, Koen
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Cytherideidae

description: Family Cytherideidae Sars, 1925
Subfamily Cytherideinae Sars, 1925
Tribe Cytherideidini Kollmann, 1960
Archeocyprideis Ducasse & Carbonel, 1994
Cyprideis Jones, 1857
Cytherissa Sars, 1925
Kavalacythereis Wouters, 1979
Mesocyprideis Wouters & Martens, 1992
Paracyprideis Klie, 1929
Romecytheridea Wouters, 1988
Sarsicytheridea Athersuch, 1982
Tanganyikacythere Ducasse & Carbonel, 1993
description: Published as part of Meisch, Claude, Smith, Robin J. & Martens, Koen, 2019, A subjective global checklist of the extant non-marine Ostracoda (Crustacea), pp. 1-135 in European Journal of Taxonomy 492 on page 22, DOI: 10.5852/ejt.2019.492, http://zenodo.org/record/3271099
Atmospheric mercury concentrations observed at ground-based monitoring sites globally distributed in the framework of the GMOS network
Creators: name: Sprovieri, Francesca
name: Pirrone, Nicola
name: Bencardino, Mariantonia
name: D'Amore, Francesco
name: Carbone, Francesco
name: Cinnirella, Sergio
name: Mannarino, Valentino
name: Landis, Matthew
name: Ebinghaus, Ralf
name: Weigelt, Andreas
name: Brunke, Ernst-Günther
name: Labuschagne, Casper
name: Martin, Lynwill
name: Munthe, John
name: Wängberg, Ingvar
name: Artaxo, Paulo
name: Morais, Fernando
name: Barbosa, H. M. J.
name: Brito, Joel
name: Cairns, Warren
name: Barbante, Carlo
name: Diéguez, María Del Carmen
name: Garcia, Patricia Elizabeth
name: Dommergue, Aurélien
name: Angot, Helene
name: Magand, Olivier
name: Skov, Henrik
name: Horvat, Milena
name: Kotnik, Jože
name: Read, Katie Alana
name: Neves, Luis Mendes
name: Gawlik, Bernd Manfred
name: Sena, Fabrizio
name: Mashyanov, Nikolay
name: Obolkin, Vladimir
name: Wip, Dennis
name: Feng, Xin Bin
name: Zhang, Hui
name: Fu, Xuewu
name: Ramachandran, Ramesh
name: Cossa, Daniel
name: Knoery, Joël
name: Marusczak, Nicolas
name: Nerentorp, Michelle
name: Norstrom, Claus
Publisher: name: Maryland Shared Open Access Repository
Year: 2016

description: Long-term monitoring of data of ambient mercury (Hg) on a global scale to assess its emission, transport, atmospheric chemistry, and deposition processes is vital to understanding the impact of Hg pollution on the environment. The Global Mercury Observation System (GMOS) project was funded by the European Commission (http://www.gmos.eu) and started in November 2010 with the overall goal to develop a coordinated global observing system to monitor Hg on a global scale, including a large network of ground-based monitoring stations, ad hoc periodic oceanographic cruises and measurement flights in the lower and upper troposphere as well as in the lower stratosphere. To date, more than 40 ground-based monitoring sites constitute the global network covering many regions where little to no observational data were available before GMOS. This work presents atmospheric Hg concentrations recorded worldwide in the framework of the GMOS project (2010–2015), analyzing Hg measurement results in terms of temporal trends, seasonality and comparability within the network. Major findings highlighted in this paper include a clear gradient of Hg concentrations between the Northern and Southern hemispheres, confirming that the gradient observed is mostly driven by local and regional sources, which can be anthropogenic, natural or a combination of both.
Cytheruridae G. W. Muller 1894
Creators: name: Meisch, Claude
name: Smith, Robin J.
name: Martens, Koen
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Cytheruridae

description: Family Cytheruridae G.W. Müller, 1894
Cytherura Sars, 1866
Semicytherura Wagner, 1957
description: Published as part of Meisch, Claude, Smith, Robin J. & Martens, Koen, 2019, A subjective global checklist of the extant non-marine Ostracoda (Crustacea), pp. 1-135 in European Journal of Taxonomy 492 on page 22, DOI: 10.5852/ejt.2019.492, http://zenodo.org/record/3271099
Hemicytheridae Puri 1953
Creators: name: Meisch, Claude
name: Smith, Robin J.
name: Martens, Koen
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Hemicytheridae

description: Family Hemicytheridae Puri, 1953
Tyrrhenocythere Ruggieri, 1955
description: Published as part of Meisch, Claude, Smith, Robin J. & Martens, Koen, 2019, A subjective global checklist of the extant non-marine Ostracoda (Crustacea), pp. 1-135 in European Journal of Taxonomy 492 on page 23, DOI: 10.5852/ejt.2019.492, http://zenodo.org/record/3271099
The Brazilian Global Atmospheric Model (BAM): Performance for Tropical Rainfall Forecasting and Sensitivity to Convective Scheme and Horizontal Resolution
Creators: name: Figueroa, Silvio N.
name: Bonatti, José P.
name: Kubota, Paulo Y.
name: Grell, Georg A.
name: Morrison, Hugh
name: Barros, Saulo R. M.
name: Fernandez, Julio P. R.
name: Ramirez, Enver
name: Siqueira, Leo
name: Luzia, Graziela
name: Silva, Josiane
name: Silva, Juliana R.
name: Pendharkar, Jayant
name: Capistrano, Vinicius B.
name: Alvim, Débora S.
name: Enoré, Diego P.
name: Diniz, Fábio L. R.
name: Satyamurti, Praki
name: Cavalcanti, Iracema F. A.
name: Nobre, Paulo
name: Barbosa, H. M. J.
name: Mendes, Celso L.
name: Panetta, Jairo
Publisher: name: Maryland Shared Open Access Repository
Year: 2016

description: This article describes the main features of the Brazilian Global Atmospheric Model (BAM), analyses of its performance for tropical rainfall forecasting, and its sensitivity to convective scheme and horizontal resolution. BAM is the new global atmospheric model of the Center for Weather Forecasting and Climate Research [Centro de Previsão de Tempo e Estudos Climáticos (CPTEC)], which includes a new dynamical core and state-of-the-art parameterization schemes. BAM’s dynamical core incorporates a monotonic two-time-level semi-Lagrangian scheme, which is carried out completely on the model grid for the tridimensional transport of moisture, microphysical prognostic variables, and tracers. The performance of the quantitative precipitation forecasts (QPFs) from two convective schemes, the Grell–Dévényi (GD) scheme and its modified version (GDM), and two different horizontal resolutions are evaluated against the daily TRMM Multisatellite Precipitation Analysis over different tropical regions. Three main results are 1) the QPF skill was improved substantially with GDM in comparison to GD; 2) the increase in the horizontal resolution without any ad hoc tuning improves the variance of precipitation over continents with complex orography, such as Africa and South America, whereas over oceans there are no significant differences; and 3) the systematic errors (dry or wet biases) remain virtually unchanged for 5-day forecasts. Despite improvements in the tropical precipitation forecasts, especially over southeastern Brazil, dry biases over the Amazon and La Plata remain in BAM. Improving the precipitation forecasts over these regions remains a challenge for the future development of the model to be used not only for numerical weather prediction over South America but also for global climate simulations.
Kliellidae Schafer 1945
Creators: name: Meisch, Claude
name: Smith, Robin J.
name: Martens, Koen
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Kliellidae

description: Family Kliellidae Schäfer, 1945
Kliella Schäfer, 1945
Nannokliella Schäfer, 1945
description: Published as part of Meisch, Claude, Smith, Robin J. & Martens, Koen, 2019, A subjective global checklist of the extant non-marine Ostracoda (Crustacea), pp. 1-135 in European Journal of Taxonomy 492 on page 23, DOI: 10.5852/ejt.2019.492, http://zenodo.org/record/3271099
Satellite retrieval of cloud condensation nuclei concentrations by using clouds as CCN chambers
Creators: name: Rosenfeld, Daniel
name: Zheng, Youtong
name: Hashimshoni, Eyal
name: Pöhlker, Mira L.
name: Jefferson, Anne
name: Pöhlker, Christopher
name: Yu, Xing
name: Zhu, Yannian
name: Liu, Guihua
name: Yue, Zhiguo
name: Fischman, Baruch
name: Li, Zhanqing
name: Giguzin, David
name: Goren, Tom
name: Artaxo, Paulo
name: Barbosa, H. M. J.
name: Pöschl, Ulrich
name: Andreae, Meinrat O.
Publisher: name: Maryland Shared Open Access Repository
Year: 2016

description: Quantifying the aerosol/cloud-mediated radiative effect at a global scale requires simultaneous satellite retrievals of cloud condensation nuclei (CCN) concentrations and cloud base updraft velocities (Wb). Hitherto, the inability to do so has been a major cause of high uncertainty regarding anthropogenic aerosol/cloud-mediated radiative forcing. This can be addressed by the emerging capability of estimating CCN and Wb of boundary layer convective clouds from an operational polar orbiting weather satellite. Our methodology uses such clouds as an effective analog for CCN chambers. The cloud base supersaturation (S) is determined by Wb and the satellite-retrieved cloud base drop concentrations (Ndb), which is the same as CCN(S). Validation against ground-based CCN instruments at Oklahoma, at Manaus, and onboard a ship in the northeast Pacific showed a retrieval accuracy of ±25% to ±30% for individual satellite overpasses. The methodology is presently limited to boundary layer not raining convective clouds of at least 1 km depth that are not obscured by upper layer clouds, including semitransparent cirrus. The limitation for small solar backscattering angles of <25° restricts the satellite coverage to ?25% of the world area in a single day.
Urban Heat Islands from Multiple Perspectives: Trends Across Disciplines and Interrelationships (Bibliographic List with Results)
Creators: name: Petrova-Antonova, Dessislava
name: Vitanova, Lidia
name: Assenova, Ina
Publisher: name: Zenodo
Year: 2024

description: The .xlsx table contains the bibliographic list with results presented in the article "Urban Heat Islands from Multiple Perspectives: Trends Across Disciplines and Interrelationships".
On the importance of cascading moisture recycling in South America
Creators: name: Zemp, D. C.
name: Schleussner, C.-F.
name: Barbosa, H. M. J.
name: Van Der Ent, R. J.
name: Donges, J. F.
name: Heinke, J.
name: Sampaio, G.
name: Rammig, A.
Publisher: name: Maryland Shared Open Access Repository
Year: 2014

description: Continental moisture recycling is a crucial process of the South American climate system. In particular, evapotranspiration from the Amazon basin contributes substantially to precipitation regionally as well as over other remote regions such as the La Plata basin. Here we present an in-depth analysis of South American moisture recycling mechanisms. In particular, we quantify the importance of cascading moisture recycling (CMR), which describes moisture transport between two locations on the continent that involves re-evaporation cycles along the way. Using an Eulerian atmospheric moisture tracking model forced by a combination of several historical climate data sets, we were able to construct a complex network of moisture recycling for South America. Our results show that CMR contributes about 9–10% to the total precipitation over South America and 17–18% over the La Plata basin. CMR increases the fraction of total precipitation over the La Plata basin that originates from the Amazon basin from 18–23 to 24–29% during the wet season. We also show that the south-western part of the Amazon basin is not only a direct source of rainfall over the La Plata basin, but also a key intermediary region that distributes moisture originating from the entire Amazon basin towards the La Plata basin during the wet season. Our results suggest that land use change in this region might have a stronger impact on downwind rainfall than previously thought. Using complex network analysis techniques, we find the eastern side of the sub-tropical Andes to be a key region where CMR pathways are channeled. This study offers a better understanding of the interactions between the vegetation and the atmosphere on the water cycle, which is needed in a context of land use and climate change in South America.
A permanent Raman lidar station in the Amazon: description, characterization, and first results
Creators: name: Barbosa, H. M. J.
name: Barja, B.
name: Pauliquevis, T.
name: Gouveia, D. A.
name: Artaxo, P.
name: Cirino, G. G.
name: Santos, R. M. N.
name: Oliveira, A. B.
Publisher: name: Maryland Shared Open Access Repository
Year: 2014

description: A permanent UV Raman lidar station, designed to perform continuous measurements of aerosols and water vapor and aiming to study and monitor the atmosphere from weather to climatic time scales, became operational in the central Amazon in July 2011. The automated data acquisition and internet monitoring enabled extended hours of daily measurements when compared to a manually operated instrument. This paper gives a technical description of the system, presents its experimental characterization and the algorithms used for obtaining the aerosol optical properties and identifying the cloud layers. Data from one week of measurements during the dry season of 2011 were analyzed as a mean to assess the overall system capability and performance. Both Klett and Raman inversions were successfully applied. A comparison of the aerosol optical depth from the lidar and from a co-located Aerosol Robotic Network (AERONET) sun photometer showed a correlation coefficient of 0.86. By combining nighttime measurements of the aerosol lidar ratio (50–65 sr), back-trajectory calculations and fire spots observed from satellites, we showed that observed particles originated from biomass burning. Cirrus clouds were observed in 60% of our measurements. Most of the time they were distributed into three layers between 11.5 and 13.4 km a.g.l. The systematic and long-term measurements being made by this new scientific facility have the potential to significantly improve our understanding of the climatic implications of the anthropogenic changes in aerosol concentrations over the pristine Amazonia.
The Chuva Project: How Does Convection Vary across Brazil?
Creators: name: Machado, Luiz A. T.
name: Dias, Maria A. F. Silva
name: Morales, Carlos
name: Fisch, Gilberto
name: Vila, Daniel
name: Albrecht, Rachel
name: Goodman, Steven J.
name: Calheiros, Alan J. P.
name: Biscaro, Thiago
name: Kummerow, Christian
name: Cohen, Julia
name: Fitzjarrald, David
name: Nascimento, Ernani L.
name: Sakamoto, Meiry S.
name: Cunningham, Christopher
name: Chaboureau, Jean-Pierre
name: Petersen, Walter A.
name: Adams, David K.
name: Baldini, Luca
name: Angelis, Carlos F.
name: Sapucci, Luiz F.
name: Salio, Paola
name: Barbosa, H. M. J.
name: Landulfo, Eduardo
name: Souza, Rodrigo A. F.
name: Blakeslee, Richard J.
name: Bailey, Jeffrey
name: Freitas, Saulo
name: Lima, Wagner F. A.
name: Tokay, Ali
Publisher: name: Maryland Shared Open Access Repository
Year: 2014

description: CHUVA, meaning “rain” in Portuguese, is the acronym for the Cloud Processes of the Main Precipitation Systems in Brazil: A Contribution to Cloud-Resolving Modeling and to the Global Precipitation Measurement (GPM). The CHUVA project has conducted five field campaigns; the sixth and last campaign will be held in Manaus in 2014. The primary scientific objective of CHUVA is to contribute to the understanding of cloud processes, which represent one of the least understood components of the weather and climate system. The five CHUVA campaigns were designed to investigate specific tropical weather regimes. The first two experiments, in Alcantara and Fortaleza in northeastern Brazil, focused on warm clouds. The third campaign, which was conducted in Belém, was dedicated to tropical squall lines that often form along the sea-breeze front. The fourth campaign was in the Vale do Paraiba of southeastern Brazil, which is a region with intense lightning activity. In addition to contributing to the understanding of cloud process evolution from storms to thunderstorms, this fourth campaign also provided a high-fidelity total lightning proxy dataset for the NOAA Geostationary Operational Environmental Satellite (GOES)-R program. The fifth campaign was carried out in Santa Maria, in southern Brazil, a region of intense hailstorms associated with frequent mesoscale convective complexes. This campaign employed a multimodel high-resolution ensemble experiment. The data collected from contrasting precipitation regimes in tropical continental regions allow the various cloud processes in diverse environments to be compared. Some examples of these previous experiments are presented to illustrate the variability of convection across the tropics.
Fulzerasib: First Approval
Creators: name: Lamb, Yvette N
Publisher: name: Adis Journals
Year: 2024
Subjects: Medicine

description: Declarations
Funding The preparation of this review was not supported by any external funding.
Authorship and Conflict of interest During the peer review process the manufacturer of the agent under review was offered an opportunity to comment on the article. Changes resulting from any comments received were made by the authors on the basis of scientific completeness and accuracy. Yvette N. Lamb is a contracted employee of Adis International Ltd/Springer Nature, and declares no relevant conflicts of interest. All authors contributed to the review and are responsible for the article content.
Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability not applicable
Additional information about this Adis Drug Review can be found here.
Abstract 
Fulzerasib (Dupert®; Innovent Biologics/GenFleet Therapeutics) is an orally active small molecule inhibitor of the KRAS G12C mutant protein being developed for the treatment of solid tumors harboring the KRAS G12C oncogenic driver mutation, includin (NSCLC) and colorectal cancer. Fulzerasib received its first approval on 21 August 2024 in China, for the treatment of adults with KRAS G12C-mutated advanced NSCLC who have received at least one line of systemic therapy. This conditional approval was based on the positive results of a single-arm, phase II study. This article summarizes the milestones in the development of fulzerasib leading to this first approval for KRAS G12C-mutated advanced NSCLC. 
© Springer Nature Switzerland AG 2024
title: Pedestrian Movement Graph Analysis
Creators: name: Fuchkina, Ekaterina
Publisher: name: Bauhaus-Universität Weimar
Year: 2017
Subjects: subject: Fußgänger
subject: Stadtplanung
subject: 710

description: Development of sustainable urban environments assumes processing of large amount of data from various sources. It could be field study observations, results of simulations or information provided by modeling. This paper focuses on processing modeled data of pedestrian movement based on existed axial maps of particular environment. Introduced component allows further analysis by calculation of set of metrics based on inverted graph, which is built from given paths.
description: Arbeitspapiere Informatik in der Architektur, vol. 16
Propagation of Strong Rainfall Events from Southeastern South America to the Central Andes
Creators: name: Boers, Niklas
name: Barbosa, H. M. J.
name: Bookhagen, Bodo
name: Marengo, José A.
name: Marwan, Norbert
name: Kurths, Jürgen
Publisher: name: AMS
Year: 2015

description: Based on high-spatiotemporal-resolution data, the authors perform a climatological study of strong rainfall events propagating from southeastern South America to the eastern slopes of the central Andes during the monsoon season. These events account for up to 70% of total seasonal rainfall in these areas. They are of societal relevance because of associated natural hazards in the form of floods and landslides, and they form an intriguing climatic phenomenon, because they propagate against the direction of the low-level moisture flow from the tropics. The responsible synoptic mechanism is analyzed using suitable composites of the relevant atmospheric variables with high temporal resolution. The results suggest that the low-level inflow from the tropics, while important for maintaining sufficient moisture in the area of rainfall, does not initiate the formation of rainfall clusters. Instead, alternating low and high pressure anomalies in midlatitudes, which are associated with an eastward-moving Rossby wave train, in combination with the northwestern Argentinean low, create favorable pressure and wind conditions for frontogenesis and subsequent precipitation events propagating from southeastern South America toward the Bolivian Andes.
title: Automatische Grundstücksumlegung mithilfe von Unterteilungsalgorithmen und typenbasierte Generierung von Stadtstrukturen
Creators: name: Knecht, Katja
name: König, Reinhard
Publisher: name: Bauhaus-Universität Weimar
Year: 2012
Subjects: subject: Automatisierung
subject: Grundstücksumlegung
subject: städtische Struktur
subject: Unterteilungsalgorithmus
subject: Computational Design
subject: 000

description: Dieses Arbeitspapier beschreibt, wie ausgehend von einem vorhandenen Straßennetzwerk Bebauungsareale mithilfe von Unterteilungsalgorithmen automatisch umgelegt, d.h. in Grundstücke unterteilt, und anschließend auf Basis verschiedener städtebaulicher Typen bebaut werden können. Die Unterteilung von Bebauungsarealen und die Generierung von Bebauungsstrukturen unterliegen dabei bestimmten stadtplanerischen Einschränkungen, Vorgaben und Parametern. Ziel ist es aus den dargestellten Untersuchungen heraus ein Vorschlagssystem für stadtplanerische Entwürfe zu entwickeln, das anhand der Umsetzung eines ersten Softwareprototyps zur Generierung von Stadtstrukturen weiter diskutiert wird.
description: Arbeitspapiere Informatik in der Architektur, vol. 15
title: Generierung von Grundriss-Layouts mittels hybrider Evolutions-Strategie
Creators: name: König, Reinhard
Publisher: name: Bauhaus-Universität Weimar
Year: 2011
Subjects: subject: CAD
subject: 620

description: Der vorliegende Text beschreibt ein computerbasiertes Verfahren zur Lösung von Layout-problemen in Architektur und Städtebau, welches mit möglichst wenig Problemwissen auskommt und schnell brauchbare Ergebnisse liefert, die durch schrittweises Hinzufügen von Problemwissen interaktiv weiter ausgearbeitet werden können. Für das generative Verfahren wurde eine Evolutions-Strategie verwendet, die mit Mechanismen zur Kollisionserkennung und virtuellen Federn zu einem hybriden Algorithmus kombiniert wurde. Dieser dient erstens der Lösung des Problems der Dichten Packung von Rechtecken sowie zweitens der Herstellung bestimmter topologischer Beziehungen zwischen diesen Rechtecken. Die Bearbeitung beider Probleme wird durch schrittweise Erweiterung grundlegender Verfahren untersucht, wobei die einzelnen Schritte anhand von Performancetests miteinander verglichen werden. Am Ende wird ein iterativer Algorithmus vorgestellt, der einerseits optimale Lösungen garantiert und andererseits diese Lösungen in einer für eine akzeptable Nutzerinteraktion ausreichenden Geschwindigkeit generiert.
description: Arbeitspapiere Informatik in der Architektur, vol. 4
title: Ergebnisse der Befragung zu Wohnstandortpräferenzen von Lebensweltsegmenten in Dresden
Creators: name: Köhler, Hermann
Publisher: name: Bauhaus-Universität Weimar
Year: 2012
Subjects: subject: Milieuforschung
subject: Residentielle Mobilität
subject: Wohnstandortpräferenzen
subject: Wohnstandortentscheidungen
subject: Quantitative Sozialforschung
subject: 300

description: In vorliegender Studie werden die Wohnstandortpräferenzen der Sinus-Milieugruppen in Dresden über eine standardisierte Befragung (n=318) untersucht. Es wird unterschieden zwischen handlungsleitenden Wohnstandortpräferenzen, die durch Anhaltspunkte auf der Handlungsebene stärker in Betracht gezogen werden sollten, und Wohnstandortpräferenzen, welche eher orientierenden Charakter haben. Die Wohnstandortpräferenzen werden untersucht anhand der Kategorien Ausstattung/Zustand der Wohnung/des näheren Wohnumfeldes, Versorgungsstruktur, soziales Umfeld, Baustrukturtyp, Ortsgebundenheit sowie des Aspektes des Images eines Stadtviertels. Um die Befragten den Sinus-Milieugruppen zuordnen zu können, wird ein Lebensweltsegment-Modell entwickelt, welches den Anspruch hat, die Sinus-Milieugruppen in der Tendenz abzubilden. Die Studie kommt zu dem Ergebnis, dass die Angehörigen der verschiedenen Lebensweltsegmente in jeder Kategorie - wenn auch z.T. auf geringerem Niveau - signifikante Unterschiede in der Bewertung einzelner Wohnstandortpräferenzen aufweisen.
description: Arbeitspapiere Informatik in der Architektur, vol. 12
title: Evolutionäre Generierung von Grundriss-Layouts mithilfe von Unterteilungsalgorithmen
Creators: name: Knecht, Katja
name: König, Reinhard
Publisher: name: Bauhaus-Universität Weimar
Year: 2011
Subjects: subject: Unterteilungsalgorithmus
subject: 600

description: Das Unterteilen einer vorgegebenen Grundfläche in Zonen und Räume ist eine im Architekturentwurf häufig eingesetzte Methode zur Grundrissentwicklung. Für deren Automatisierung können Unterteilungsalgorithmen betrachtet werden, die einen vorgegebenen, mehrdimensionalen Raum nach einer festgelegten Regel unterteilen. Neben dem Einsatz in der Computergrafik zur Polygondarstellung und im Floorplanning zur Optimierung von Platinen-, Chip- und Anlagenlayouts finden Unterteilungsalgorithmen zunehmend Anwendung bei der automatischen Generierung von Stadt- und Gebäudegrundrissen, insbesondere in Computerspielen. Im Rahmen des Forschungsprojekts Kremlas wurde das gestalterische und generative Potential von Unterteilungsalgorithmen im Hinblick auf architektonische Fragestellungen und ihre Einsatzmöglichkeiten zur Entwicklung einer kreativen evolutionären Entwurfsmethode zur Lösung von Layoutproblemen in Architektur und Städtebau untersucht. Es entstand ein generativer Mechanismus, der eine Unterteilungsfolge zufällig erstellt und Grundrisse mit einer festgelegten Anzahl an Räumen mit bestimmter Raumgröße durch Unterteilung generiert. In Kombination mit evolutionären Algorithmen lassen sich die erhaltenen Layoutlösungen zudem hinsichtlich architektonisch relevanter Kriterien optimieren, für die im vorliegenden Fall Nachbarschaftsbeziehungen zwischen einzelnen Räumen betrachtet wurden.
description: Arbeitspapiere Informatik in der Architektur, vol. 10
title: Nutzerinteraktion bei der computergestützten Generierung von Layouts
Creators: name: König, Reinhard
name: Schneider, Sven
Publisher: name: Bauhaus-Universität Weimar
Year: 2011
Subjects: subject: Interaktion
subject: 600

description: Das vorliegende Arbeitspapier beschäftigt sich mit der Thematik der Nutzerinteraktion bei computerbasierten generativen Systemen. Zunächst wird erläutert, warum es notwendig ist, den Nutzer eines solchen Systems in den Generierungsprozess zu involvieren. Darauf aufbauend werden Anforderungen an ein interaktives generatives System formuliert. Anhand eines Systems zur Generierung von Layouts werden Methoden diskutiert, um diesen Anforderungen gerecht zu werden. Es wird gezeigt, dass sich insbesondere evolutionäre Algorithmen für ein interaktives entwurfsunterstützendes System eignen. Es wird kurz beschrieben, wie sich Layoutprobleme durch eine evolutionäre Strategie lösen lassen. Abschließend werden Fragen bezüglich der grafischen Darstellung von Layoutlösungen und der Interaktion mit dem Dargestellten diskutiert.
description: Arbeitspapiere Informatik in der Architektur, vol. 8
title: Analyse und Generierung von Straßennetzwerken mittels graphenbasierter Methoden
Creators: name: Anders, Frauke
name: König, Reinhard
Publisher: name: Bauhaus-Universität Weimar
Year: 2011
Subjects: subject: Graph
subject: 600

description: Der vorliegende Beitrag ist in zwei thematische Teilebereiche gegliedert. Der erste Teil beschäftigt sich mit der Analyse von Graphen, insbesondere von Graphen, die Straßennetzwerke repräsentieren. Hierzu werden Methoden aus der Graphentheorie angewendet und Kenngrößen aus der Space Syntax Methode ausgewertet. Ein Framework, welches basierend auf der Graphentheorie in Architektur und Stadtplanung Einzug gehalten hat, ist die Space Syntax Methode. Sie umfasst die Ableitung unterschiedlicher Kenngrößen eines Graphen bzw. Netzwerkes, wodurch eine Analyse für architektonische und stadtplanerische Zwecke ermöglicht wird. Der zweite Teil dieses Berichts beschäftigt sich mit der Generierung von Graphen, insbe-sondere der von Straßennetzwerkgraphen. Die generativen Methoden basieren zum Teil auf den gewonnenen Erkenntnissen der Analyse von Straßennetzwerken. Es werden unterschiedliche Ansätze untersucht, um verschiedene Parameterwerte zur Generierung von Straßengraphen festzulegen. Als Ergebnis der Arbeiten ist ein Softwaretool entstanden, welches es erlaubt, auf Grundlage einer Voronoi-Tesselierung realistische Straßennetzwerkgraphen zu erzeugen.
description: Arbeitspapiere Informatik in der Architektur, vol. 7
title: Entwerfen Versionieren: Probleme und Lösungsansätze für die Organisation verteilter Entwurfsprozesse
Creators: name: Schneider, Sven
name: Braunes, Jörg
name: Thurow, Torsten
name: König, Reinhard
name: Tonn, Christian
Publisher: name: Bauhaus-Universität Weimar
Year: 2011
Subjects: subject: CAD
subject: 620

description: Entwerfen ist ein komplexer Vorgang. Soll dieser Vorgang nicht allein, sondern räumlich verteilt mit mehreren Beteiligten gemeinsam stattfinden, so sind digitale Werkzeuge zur Unterstützung dieses Prozesses unumgänglich. Die Verwendung von Werkzeugen für Ent-wurfsprozesse bedeutet jedoch immer auch eine Manipulation des zu unterstützenden Prozesses selbst. Im Falle von Werkzeugen zur Unterstützung der Kollaboration mehrerer Beteiligter stellen die implementierten Koordinationsmechanismen solche prozessbeeinflussenden Faktoren dar. Damit diese Mechanismen, entsprechend der Charakteristika kreativer Prozesse, so flexibel wie möglich gestaltet werden können, liegt die Anforderung auf technischer Ebene darin, ein geeignetes Konzept für eine nachvollziehbare Speicherung (Versionierung) der stattfindenden Entwurfshandlungen zu schaffen. Der vorliegende Artikel beschäftigt sich mit dem Thema der Entwurfsversionierung in computergestützten kollaborativen Arbeitsumgebungen. Vor dem Hintergrund, dass die Versionierung den kreativen Entwurfsprozess möglichst wenig manipulieren soll, werden technische sowie konzeptionelle Probleme der diskutiert und Lösungsansätze für diese vorgestellt.
description: Arbeitspapiere Informatik in der Architektur, vol. 5
Thinking with Keywords: Investigating the Role and Nature of Professionalism Keywords in TPC Enculturation
Creators: name: Hannah, Mark A.
name: Caputo, Courtney
name: Deen, Lily
name: Hedquist, Amber
name: Salgado, Catherine
name: Shah, Seher
name: Cruser, Laura
name: Fluty, Chris
name: Lane, Tom
name: Rebe, Tristan
name: Sutrisno, Dwi Budidarma
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biophysics
Biochemistry
Biotechnology
Science Policy

description: This article examines the role of TPC professionalism keywords on early career scholars’ disciplinary enculturation. The article reports on a collaboration between the article’s authors that explored how the deployment of professionalism keywords in teaching and research created conditions for defining what it might mean to work as a TPC professional. The article offers insights into the challenges keywords pose to forwarding non-normative understandings of professionalism that enable broader inclusion and visibility for TPC stakeholders.
title: Vapor de Água na Atmosfera: do efeito estufa às mudanças climáticas
title: Water vapor in the atmosphere: from greenhouse effect to climate change
titleType: AlternativeTitle
Creators: name: Barbosa, H. M. J.
Publisher: name: USP
Year: 2014
Subjects: clouds
balanço de radiação terrestre.
Earth radiation budget.
efeito estufa
greenhouse effect
nuvens
vapor de água
water vapor

description: Uma molecula de agua interage tanto com a radiacao solar quanto com a radiacao de onda longa emitida pela superficie do nosso planeta. Se nao fosse por essa absorcao, que responde por 2/3 do efeito estufa natural e mantem a atmosfera e a superficie aquecidas, o clima nao seria como conhecemos hoje e possivelmente nao haveria vida na Terra. A presenca do vapor de agua no sistema climatico tambem possibilita um eficiente transporte vertical de energia da superficie para a troposfera, modificando o perfil de temperatura atraves das trocas de calor envolvidas nas mudancas de fase ao se formar uma nuvem. As nuvens, por sua vez, cobrem 2/3 do ceu, e sua interacao com a radiacao solar aumenta o albedo planetario de 15% para 30%, mas ao mesmo tempo tambem absorvem radiacao infravermelha que de outro modo seria perdida para o espaco. Neste artigo, iremos mostrar que, para continuar avancando no entendimento do clima e das mudancas climaticas, temos que continuar avancando nosso entendimento dos processos que envolvem o vapor de agua e as nuvens na nossa atmosfera.
How Sea Level Rise May Hit You Through the Backdoor: Changing Extreme Water Levels in Shallow Coastal Lagoons
Creators: name: Gräwe, Ulf
Publisher: name: Zenodo
Year: 2025

description: Due to their choked geometry, coastal lagoons can attenuate extreme water levels compared to the open sea. However, this protective property is expected to decrease due to sea-level rise. By studying idealized lagoons in a non-dimensional parameter space, this study describes non-linear interactions between tides, storm surges, freshwater fluxes into the lagoon, and sea-level rise. The non-dimensional numbers include lagoon geometry and forcing scales. The main objective is to provide an overview of potentially affected lagoons and to highlight the importance of attenuation changes due to sea-level rise. Tidal and storm surge induced maximum water levels inside lagoons rise faster than sea-level rise for most of the parameter space. Maximum water levels due to freshwater fluxes rise slower than sea-level rise for strongly choked lagoons. For compound events, the response between rising faster or slower than sea-level rise depends strongly on the lagoon geometry.