cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Stakeholder perceptions of event attribution in the loss and damage debate
Creators: name: Parker, Hannah R.
name: Boyd, Emily
name: Cornforth, Rosalind J.
name: James, Rachel
name: Otto, Friederike E. L.
name: Allen, Myles R.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: In 2013 the Warsaw International Mechanism (WIM) for loss and damage (L&D) associated with climate change impacts was established under the United Nations Framework Convention on Climate Change (UNFCCC). For scientists, L&D raises questions around the extent that such impacts can be attributed to anthropogenic climate change, which may generate complex results and be controversial in the policy arena. This is particularly true in the case of probabilistic event attribution (PEA) science, a new and rapidly evolving field that assesses whether changes in the probabilities of extreme events are attributable to GHG emissions. If the potential applications of PEA are to be considered responsibly, dialogue between scientists and policy makers is fundamental. Two key questions are considered here through a literature review and key stakeholder interviews with representatives from the science and policy sectors underpinning L&D. These provided the opportunity for in-depth insights into stakeholders’ views on firstly, how much is known and understood about PEA by those associated with the L&D debate? Secondly, how might PEA inform L&D and wider climate policy? Results show debate within the climate science community, and limited understanding among other stakeholders, around the sense in which extreme events can be attributed to climate change. However, stakeholders do identify and discuss potential uses for PEA in the WIM and wider policy, but it remains difficult to explore precise applications given the ambiguity surrounding L&D. This implies a need for stakeholders to develop greater understandings of alternative conceptions of L&D and the role of science, and also identify how PEA can best be used to support policy, and address associated challenges. Policy relevance The WIM was established to address the negative impacts of climate change, but whether attribution evidence will be required to link impacts to climate change is yet to be determined, and also controversial. Stakeholders show little awareness of PEA and agreement on its role, which raises important questions for policy. Dialogue between policymakers, practitioners and scientists could help to build a broader understanding of PEA, to determine whether it is relevant, and facilitate both its development and WIM high level decision-making processes.
title: Catalogus Realis. VI. Historische Hilfswissenschaften. VIa. Geographie (hier auch die heutige Völkerkunde)
Creators: name: Philipps-Universität Marburg
Publisher: name: Philipps-Universität Marburg
Year: 2020
Subjects: Hassiaca
Systematischer Katalog
Library and information sciences
Bibliotheks- und Informationswissenschaft

description: Elektronische Reproduktion von: Catalogus Realis. VI. Historische Hilfswissenschaften. VIa. Geographie. - Stand: Dezember 2019. - Standort: Universität Marburg, Universitätsbibliothek. - Signatur: Sonderlesesaal. - Bemerkungen: Der Katalog verzeichnet in systematisch-sachlicher Ordnung den Bestand der Universitätsbibliothek Marburg von den Anfängen bis 1957. Später erworbene ältere Literatur ist hier nicht verzeichnet. Mit Hilfe dieses Katalogs ist die Suche nach Literatur zu bestimmten Inhalten und Themen möglich. – Zur Systematik: Die Signaturen der einzelnen Bücher und Zeitschriften geben die Ordnung des Bestands wieder. Alle Signaturen beginnen mit einer römischen Zahl von I (1) bis XX (20), die das jeweilige Fach (Theologie, Geschichte, Medizin usw.) bezeichnet. Die weitere Untergliederung ergibt sich aus den nachfolgenden Kleinbuchstaben und arabischen Zahlen. Beispiel: XVIa A 117. Die Großbuchstaben A, B und C sind nicht Teil der Systematik, sondern bezeichnen das Format der betreffenden Bände: A = Folio (großformatige Bände), B = Quart (mittelgroße Bände), C = Oktav (kleinformatige Bände). - Digitalisiert 2020
Effects of titanium dioxide nanoparticle exposure in Mytilus galloprovincialis gills and digestive gland
Creators: name: Gornati, Rosalba
name: Longo, Arturo
name: Rossi, Federica
name: Maisano, Maria
name: Sabatino, Giuseppe
name: Mauceri, Angela
name: Bernardini, Giovanni
name: Fasulo, Salvatore
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Cancer
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Biotechnology
subject: Pharmacology
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Biochemistry

description: Despite the wide use of nanoscale materials in several fields, some aspects of the nanoparticle behavior have to be still investigated. In this work, we faced the aspect of environmental effects of increasing concentrations of TiO2NPs using the Mytilus galloprovincialis as animal model and carrying out a multidisciplinary approach to better explain the results. Bioaccumulation suggested that the gills and digestive gland are the most sensitive organs to TiO2NP exposure. Histological observations have evidenced an altered tissue organization and a consistent infiltration of haemocytes, as a consequence of the immune system activation, even though an increase in lipid peroxidation is uncertain and DNA damage became relevant only at high exposure dose (10 mg/L) or for longer exposure time (96 h). However, the over expression of SOD1 mRNA, strengthen the concept that the toxicity of TiO2NPs could occur indirectly by ROS production. TEM analysis showed the presence of multilamellar bodies, RER fragmentation and cytoplasmic vacuolization within relevant presence of dense granules, residual bodies and lipid inclusions. These findings support the evidence of an initial inflammatory response by the cells of the target organs leading to apoptosis. In conclusion, we can state that, certainly the exposure to TiO2NPs has affected our animal model from cellular to molecular levels. Interestingly, the same responses are caused by lower TiO2NP concentration and longer exposure time as well as higher doses and shorter exposure. We do not know if some of the conditions detected are reversible, then further studies are required to clarify this aspect.
Stakeholder perceptions of event attribution in the loss and damage debate
Creators: name: Parker, Hannah R.
name: Boyd, Emily
name: Cornforth, Rosalind J.
name: James, Rachel
name: Otto, Friederike E. L.
name: Allen, Myles R.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: In 2013 the Warsaw International Mechanism (WIM) for loss and damage (L&D) associated with climate change impacts was established under the United Nations Framework Convention on Climate Change (UNFCCC). For scientists, L&D raises questions around the extent that such impacts can be attributed to anthropogenic climate change, which may generate complex results and be controversial in the policy arena. This is particularly true in the case of probabilistic event attribution (PEA) science, a new and rapidly evolving field that assesses whether changes in the probabilities of extreme events are attributable to GHG emissions. If the potential applications of PEA are to be considered responsibly, dialogue between scientists and policy makers is fundamental. Two key questions are considered here through a literature review and key stakeholder interviews with representatives from the science and policy sectors underpinning L&D. These provided the opportunity for in-depth insights into stakeholders’ views on firstly, how much is known and understood about PEA by those associated with the L&D debate? Secondly, how might PEA inform L&D and wider climate policy? Results show debate within the climate science community, and limited understanding among other stakeholders, around the sense in which extreme events can be attributed to climate change. However, stakeholders do identify and discuss potential uses for PEA in the WIM and wider policy, but it remains difficult to explore precise applications given the ambiguity surrounding L&D. This implies a need for stakeholders to develop greater understandings of alternative conceptions of L&D and the role of science, and also identify how PEA can best be used to support policy, and address associated challenges. Policy relevance The WIM was established to address the negative impacts of climate change, but whether attribution evidence will be required to link impacts to climate change is yet to be determined, and also controversial. Stakeholders show little awareness of PEA and agreement on its role, which raises important questions for policy. Dialogue between policymakers, practitioners and scientists could help to build a broader understanding of PEA, to determine whether it is relevant, and facilitate both its development and WIM high level decision-making processes.
Functional Stability and Structural Transitions of Kallikrein: Spectroscopic and Molecular dynamics studies
Creators: name: Sayli Dalal
name: Mhashal, Anil
name: Narendra Kadoo
name: Sushama M. Gaikwad
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Computational Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Meta Science
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Physics
subject: Biochemistry
subject: Biophysics

description: Kallikrein, a physiologically vital serine protease was investigated for its functional and conformational transitions during chemical (organic solvents, Gdn-HCl), thermal, and pH induced denaturation using biochemical and biophysical techniques and molecular dynamics (MD) simulations approach. The enzyme was exceptionally stable in isopropanol and ethanol showing 110% and 75% activity, respectively after 96h, showed moderate tolerance in acetonitrile (45% activity after 72 h) and much lower stability in methanol (40% activity after 24h) (all the solvents [90% v/v]). Far UV CD and fluorescence spectra indicated apparent reduction in compactness of KLKp structure in isopropanol system. MD simulation studies of the enzyme in isopropanol revealed 1) minimal deviation of the structure from native state 2) marginal increase in radius of gyration (Rg) and solvent accessible surface area (SASA) of the protein and the active site and 3) loss of density barrier at the active site possibly leading to increased accessibility of substrate to catalytic triad as compared to methanol and acetonitrile. Although kallikrein was structurally stable up to 90°C as indicated by secondary structure monitoring, it was functionally stable only up to 45°C, implicating thermolabile active site geometry. In GdnHCl [1.0 M], 75% of the activity of KLKp was retained after incubation for 4h, indicating its denaturant tolerance. A molten globule like structure of KLKp formed at pH 1.0 was more thermostable and exhibited interesting structural transitions in organic solvents. The above results provide deeper understanding of functional and structural stability of the serine proteases at molecular level.
Additional file 1 of Anti-SARS-CoV-2 IgA and IgG in human milk after vaccination is dependent on vaccine type and previous SARS-CoV-2 exposure: a longitudinal study
Creators: name: Selma-Royo, Marta
name: Bäuerl, Christine
name: Mena-Tudela, Desirée
name: Aguilar-Camprubí, Laia
name: Pérez-Cano, Francisco J.
name: Parra-Llorca, Anna
name: Lerin, Carles
name: Martínez-Costa, Cecilia
name: Collado, Maria Carmen
Publisher: name: figshare
Year: 2022
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1: Table S1. Reported maternal and infant side-effects after vaccination. Table S2. Results from the longitudinal mixed-effects analysis modeling the changes in IgG and IgA detection in human breast milk after vaccination. Figure S1. Individual trajectories of the SARS-CoV-2 IgG in breast milk samples according to vaccine from baseline (before the 1st dose) to 3-4 weeks post vaccination course (A-C) and grouped by vaccine (D-F). Data is presented as log-transformed arbitrary units (AU) and AU ± 95% CI. Figure S2. Individual trajectories of the SARS-CoV-2 IgA in breast milk samples according to vaccine from baseline transformed arbitrary units (AU) and AU ± 95% CI. Table S3. Percentage of mothers with a signal above the established cut-off for a positive result for SARS-CoV-2 antibody presence according to vaccine. Table S4. Results from the longitudinal mixed-effects analysis modeling the changes in IgG and IgA detection in human breast milk at baseline and each analyzed time after vaccination according to vaccine.
Cultural influences on exercise participation and fall prevention: a systematic review and narrative synthesis
Creators: name: Clemson, Lindy
name: R., Stephen
name: Sherrington, Catherine
name: Haeyoung Jang
name: Lovarini, Meryl
name: Willis, Karen
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Medicine

description: Purpose: We aim to provide a systematic review of qualitative research evidence relevant to the experiences and perceptions of program providers and participants from culturally and linguistically diverse (CALD) backgrounds regarding (i) exercise and (ii) fall prevention programs for older people. Method: Using a narrative synthesis approach, we reviewed published journal articles reporting qualitative data. Electronic and manual literature searches were conducted to identify 19 publications that met the inclusion criteria. Of these, 16 discussed exercise and three focused on broader fall prevention programs. However, no studies were identified that explored the perspective of the program providers. Results: An overarching theme emerged identifying the influence of cultural values and perceptions on program participation. Also, identified were motivational, social and environmental influences. Conclusion: Exercise and fall prevention interventions need to be culturally appropriate and utilise the positive influences of social support, especially from physicians and family. While these findings can be used to inform the delivery of programs to these population groups, future studies should focus specifically on experiences and perceptions of older CALD people of fall prevention programs as well as the perspectives of program providers.Implications for RehabilitationProgram participation is influenced by cultural values and motivational, social and environmental factors.The meaning and importance of exercise can vary between and within cultures.Exercise and fall prevention interventions need to be culturally appropriate and utilise the positive influences of social support, especially from physicians and family.Providing information that falls can be prevented and the reasons why behaviours need to change will be more likely to encourage older people from CALD backgrounds to contemplate participation.
Measured removal rates of chrysotile asbestos fibers from air and comparison with theoretical estimates based on gravitational settling and dilution ventilation
Creators: name: J. Sahmel
name: H. J. Avens
name: P. K. Scott
name: K. Unice
name: A. Burns
name: C. A. Barlow
name: A. K. Madl
name: J. Henshaw
name: D. J. Paustenbach
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences

description: Context: Industrial hygiene assessments often focus on activity-based airborne asbestos concentration measurements, but few empirical data exist regarding the fiber removal rate from air after activities cease. Objective: Grade 7T chrysotile indoor fiber settling (FS) rates were characterized using air sampling (NIOSH Method 7402). Materials and methods: Six replicate events were conducted in a 58 m3 study chamber (ventilation 3.5 ACH), in which chrysotile-contaminated work clothing was manipulated for 15 min followed by 30 min of no activity. The fiber concentration decay constant and removal rate were characterized using an exponential decay model based on the measurements. Results: Breathing zone airborne chrysotile concentrations decreased by 86% within 15–30 min after fiber disturbance, compared to concentrations during active disturbance (p Discussion: Other measurement studies have reported similar airborne fiber removal rates, supporting the finding that factors other than gravitational settling and dilution ventilation contribute measurably to PCM fiber removal from air (e.g. impaction, agglomeration). Conclusion: Overall, the scientific weight of evidence indicates that the time necessary for removal of 99% of fibers greater than 5 μm in length (with aspect ratios greater than 3:1) is approximately 20–80 min.
Additional file 1 of Simultaneous or staged resection for synchronous liver metastasis and primary rectal cancer: a propensity score matching analysis
Creators: name: Karam, Elias
name: Bucur, Petru
name: Gil, Camille
name: Sindayigaya, Remy
name: Tabchouri, Nicolas
name: Barbier, Louise
name: Pabst-Giger, Urs
name: Bourlier, Pascal
name: Lecomte, Thierry
name: Moussata, Driffa
name: Chapet, Sophie
name: Calais, Gilles
name: Ouaissi, Mehdi
name: Salamé, Ephrem
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Additional file 1: Figure S1. Comparison flowchart of patients’ adjuvant managements between staged and simultaneous group.
Chemical characterisation of old cabbage (Brassica oleracea L. var. acephala) seed oil by liquid chromatography and different spectroscopic detection systems
Creators: name: Cacciola, Francesco
name: Beccaria, Marco
name: Oteri, Marianna
name: Utczas, Margita
name: Giuffrida, Daniele
name: Cicero, Nicola
name: Dugo, Giacomo
name: Dugo, Paola
name: Mondello, Luigi
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: We report an extensive chemical characterisation of fatty acids, triacylglycerols, tocopherols, carotenoids and polyphenols contained in the oil extracted from old cabbage (Brassica oleracea L. var. acephala) by cold-pressing of the seeds. Analyses were performed by GC-FID combined with mass spectrometry, HPLC with photodiode array, fluorescence and mass spectrometry detection. The 94% of the total fatty acids were unsaturated, rappresented by erucic acid (more than 50%) followed by linoleic, linolenic and oleic acids accounting for approximately 10% each. The most abundant triacylglycerols (>13%) were represented by erucic–gadolenic–linoleic, erucic–eruci–linoleic and erucic–erucic–oleic. Among tocopherols, γ-tocopherol accounted for over 70% of the total content. Thirteen carotenoids and 11 polyphenols were identified and measured. In particular, the total content in carotenoids was 10.9 ppm and all-E-lutein was the main component (7.7 ppm); among polyphenols, six hydroxycinnamic acids and five flavonoids, were identified by combining information from retention times, PDA and MS data.
Additional file 2 of Simultaneous or staged resection for synchronous liver metastasis and primary rectal cancer: a propensity score matching analysis
Creators: name: Karam, Elias
name: Bucur, Petru
name: Gil, Camille
name: Sindayigaya, Remy
name: Tabchouri, Nicolas
name: Barbier, Louise
name: Pabst-Giger, Urs
name: Bourlier, Pascal
name: Lecomte, Thierry
name: Moussata, Driffa
name: Chapet, Sophie
name: Calais, Gilles
name: Ouaissi, Mehdi
name: Salamé, Ephrem
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Additional file 2. Table S1. Intraoperative parameters of the 48 patients with rectal cancer and synchronous liver metastases undergoing staged surgery according to their management.
Measured removal rates of chrysotile asbestos fibers from air and comparison with theoretical estimates based on gravitational settling and dilution ventilation
Creators: name: J. Sahmel
name: H. J. Avens
name: P. K. Scott
name: K. Unice
name: A. Burns
name: C. A. Barlow
name: A. K. Madl
name: J. Henshaw
name: D. J. Paustenbach
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences

description: Context: Industrial hygiene assessments often focus on activity-based airborne asbestos concentration measurements, but few empirical data exist regarding the fiber removal rate from air after activities cease. Objective: Grade 7T chrysotile indoor fiber settling (FS) rates were characterized using air sampling (NIOSH Method 7402). Materials and methods: Six replicate events were conducted in a 58 m3 study chamber (ventilation 3.5 ACH), in which chrysotile-contaminated work clothing was manipulated for 15 min followed by 30 min of no activity. The fiber concentration decay constant and removal rate were characterized using an exponential decay model based on the measurements. Results: Breathing zone airborne chrysotile concentrations decreased by 86% within 15–30 min after fiber disturbance, compared to concentrations during active disturbance (p Discussion: Other measurement studies have reported similar airborne fiber removal rates, supporting the finding that factors other than gravitational settling and dilution ventilation contribute measurably to PCM fiber removal from air (e.g. impaction, agglomeration). Conclusion: Overall, the scientific weight of evidence indicates that the time necessary for removal of 99% of fibers greater than 5 μm in length (with aspect ratios greater than 3:1) is approximately 20–80 min.
Recent changes in breast cancer incidence and mortality in Estonia: Transition to the west
Creators: name: Baburin, Aleksei
name: Aareleid, Tiiu
name: Rahu, Mati
name: Reedik, Lauri
name: Innos, Kaire
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: Computational Biology

description: Background The aim of this study was to examine breast cancer (BC) incidence and mortality trends in Estonia during recent decades and to compare the pattern of these trends with other selected European countries and regions. We attempt to explain the findings in relation to changes in Estonian society and healthcare system. Methods BC incidence (1985–2012) and mortality (1985–2013) data for Estonia were obtained from the Estonian Cancer Registry and Statistics Estonia. Data for selected European countries were obtained from the EUREG database. Joinpoint regression was used to analyze age-standardized rates in Estonia by age. For international comparison of incidence and mortality rates, we used scatterplot with 95% confidence ellipses and the mortality to incidence ratio. Results The overall BC incidence continues to increase in Estonia, while mortality has been in decline since 2000. Both incidence and mortality trends varied considerably across age groups. Among women aged 60 years and older, BC incidence increased at a rate of nearly 3% per year. Significant decrease in mortality was seen only among women aged 50–59 years. Comparison of scatterplots between countries and regions revealed two clusters in Europe separated along the incidence axis. The correlation between incidence and mortality in Estonia changed its direction in the mid-1990s. Conclusion In recent years, the dynamics of BC burden in Estonia has transitioned towards the high incidence–low mortality type model, which is characteristic to Western, Northern and Southern Europe. Although overall BC incidence is much lower in Estonia than in more affluent European countries, mortality from BC is still relatively high, particularly among elderly women.
Additional file 3 of Simultaneous or staged resection for synchronous liver metastasis and primary rectal cancer: a propensity score matching analysis
Creators: name: Karam, Elias
name: Bucur, Petru
name: Gil, Camille
name: Sindayigaya, Remy
name: Tabchouri, Nicolas
name: Barbier, Louise
name: Pabst-Giger, Urs
name: Bourlier, Pascal
name: Lecomte, Thierry
name: Moussata, Driffa
name: Chapet, Sophie
name: Calais, Gilles
name: Ouaissi, Mehdi
name: Salamé, Ephrem
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Additional file 3. Table S2. Pathology results of the 48 patients with rectal cancer and synchronous liver metastases undergoing staged surgery according to their management.
[2]Rotaxanes comprising a macrocylic Hamilton receptor obtained using active template synthesis: synthesis and guest complexation
Creators: name: Tron, Arnaud
name: Thornton, Peter J.
name: Kauffmann, Brice
name: Tucker, James H. R.
name: McClenaghan, Nathan D.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Computational Biology

description: A macrocyclic ring comprising multiple hydrogen-bonding sites as well as metal-chelating sites is shown to play the role of ligand in active templated, copper-catalysed [2]rotaxane formation via Huisgen and Glaser reactions. The crystallographic structure and copper ion binding studies are provided for the free macrocycle, along with molecular modelling, barbital, N,N′-trimethyleneurea and copper (I) binding information for the new rotaxanes.
Chemical constituents isolated from Zygophyllum melongena Bunge growing in Mongolia
Creators: name: Chunsriimyatav Ganbaatar
name: Gruner, Margit
name: Jigjidsuren Tunsag
name: Dulamjav Batsuren
name: Batsuren Ganpurev
name: Lkhamjav Chuluunnyam
name: Batsuren Sodbayar
name: Schmidt, Arndt W.
name: Hans-Joachim Knölker
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Inorganic Chemistry

description: We report the first investigation of the chemical constituents of Zygophyllum melongena Bunge, a species growing in Mongolia. The quinovic acid glycosides 3-O-(β-D-glucopyranosyl)quinovic acid and 3-O-(β-D-glucopyranosyl)quinovic acid (28→1)-(β-D-glucopyranosyl) ester were identified in the chloroform fraction along with the flavonoid glycoside astragalin. The n-butanol fraction contained (+)-D-pinitol as the major component, a cyclitol with anti-diabetic properties. The structures of the isolated natural products were confirmed using ESI-MS and NMR spectroscopy (1H, 13C, COSY, HSQC, HMBC, NOESY and ROESY). This is the first report of the isolation of (+)-D-pinitol from the genus Zygophyllum.
Input-output flows and developmental implications for Polish agriculture
Creators: name: Góral, Justyna
name: Mrówczyńska-Kamińska, Aldona
name: Klimkowski, Cezary
name: Góral, Justyna
name: Mrówczyńska-Kamińska, Aldona
name: Klimkowski, Cezary
Publisher: name: Unknown
Year: 2017
Subjects: subject: Agribusiness
subject: Agricultural Finance
subject: input-output analysis
subject: Polish agribusiness sector
subject: Polish agriculture
subject: food industry
subject: agriculture
subject: economy
subject: development
subject: projection
subject: input-output flows
subject: agribusiness
subject: Poland

description: Discussing selected issues referring to input-output analysis, identifying on this basis the role of Polish agribusiness sector in national economy and creating short- and mid-term projections about changes in these parts of input-output tables that concern Polish agriculture and food industry. Chapters: The importance of agriculture in the economy. Analysis of development processes in agriculture at using input-output tables. Projection of input-output flows in agribusiness in Poland after 2020. Projection of changes in the structure of input-output flows and international experience.
Additional file 1 of Ancylostoma in dogs in the Caribbean: a review and study from St. Kitts, West Indies
Creators: name: Kim, Jenny
name: Lucio-Forster, Araceli
name: Ketzis, Jennifer K.
Publisher: name: figshare
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Computational Biology

description: Additional file 1: Table S1. Ancylostoma positivity rate by Parish for St. Kitts, 2014.
Additional file 1 of Evaluation of the risk of malnutrition in hospitalized children by PYMS, STAMP, and STRONGkids tools and comparison with their anthropometric indices: a cross-sectional study
Creators: name: Malekiantaghi, Armen
name: AsnaAshari, Kosar
name: Shabani-Mirzaee, Hosein
name: Vigeh, Mohsen
name: Sadatinezhad, Mohsen
name: Eftekhari, Kambiz
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Additional file 1: Supplementary Table 1. STRONGkids tool. Supplementary Table 2. PYMS tool. Supplementary Table 3. STAMP tool. Supplementary Table 4. A summary of reasons for admission.
Additional file 1 of Tolvaptan versus fluid restriction in acutely hospitalised patients with moderate-profound hyponatraemia (TVFR-HypoNa): design and implementation of an open-label randomised trial
Creators: name: Warren, Annabelle M.
name: Grossmann, Mathis
name: Hoermann, Rudolf
name: Zajac, Jeffrey D.
name: Russell, Nicholas
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 60506 Virology
subject: FOS: Biological sciences
subject: Computational Biology

description: Additional file 1: Appendix 1. Austin Health Human Research Ethics Committee Approval Letter
SNAP Redemptions Contributed to Employment During the Great Recession
Creators: name: Pender, John
name: Jo, Young
name: Pender, John
name: Jo, Young
Publisher: name: Unknown
Year: 2019
Subjects: subject: Financial Economics
subject: Food Consumption/Nutrition/Food Safety
subject: Food Security and Poverty
subject: Health Economics and Policy
subject: Supplemental Nutrition Assistance Program (SNAP)
subject: food
subject: nutrition
subject: assistance

description: The Supplemental Nutrition Assistance Program (SNAP) provided benefits to an average of more than 46 million recipients per month and accounted for 52 percent of USDA’s spending during fiscal year 2014. Payments under USDA’s Supplemental Nutrition Assistance Program (SNAP) nearly quadrupled between 2001 and 2013, after adjusting for inflation, growing rapidly during and immediately after the Great Recession. Recent ERS research found that SNAP redemptions were associated with increased local employment—with $10,000 of redemptions contributing to 0.4 additional urban jobs and 1.0 additional rural jobs.
Additional file 3 of Tolvaptan versus fluid restriction in acutely hospitalised patients with moderate-profound hyponatraemia (TVFR-HypoNa): design and implementation of an open-label randomised trial
Creators: name: Warren, Annabelle M.
name: Grossmann, Mathis
name: Hoermann, Rudolf
name: Zajac, Jeffrey D.
name: Russell, Nicholas
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 60506 Virology
subject: FOS: Biological sciences
subject: Computational Biology

description: Additional file 3: Appendix 3. Tolvaptan (Samsca) product information
Metabolic profile of Fructus Gardeniae in human plasma and urine using ultra high-performance liquid chromatography coupled with high-resolution LTQ-orbitrap mass spectrometry
Creators: name: Gao-Wa Wang
name: Burenbatu Bao
name: Han, Zhi-Qiang
name: Han, Qing-Yu
name: Yang, Xiu-Lan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: 1. In China, Fructus Gardeniae was used as a traditional Chinese medicine (TCM) with a wide array of biological activities. The bioactive components identified in Fructus Gardeniae mainly included iridoids, flavonids, pigments, and so on. Among them, iridoids were regarded as important compounds in Fructus Gardeniae. Though analyses of the constituents in biological samples after oral administration of Fructus Gardeniae effective fraction or its active compounds have been reported, few efforts have been made to investigate the metabolic profile of Fructus Gardeniae in humans. In this study, the constituents and metabolites of Fructus Gardeniae in human blood and urine after oral administration of Fructus Gardeniae were investigated using ultra high-performance liquid chromatography (UHPLC) coupled with high-resolution LTQ-Orbitrap mass spectrometery. 2. Totally, 14 constituents (two parent compounds and 12 metabolites) of Fructus Gardeniae were identified in human plasma and urine either by comparing the retention time and mass spectrometry data with that of reference compounds or by the accurate high-resolution MS/MS data of the chemicals. The compounds identified were mainly iridoid glycosides such as geniposide and the derivatives of genipin-O-glucuronide. Among them, 11 metabolites were detected in human plasma and urine while the other three metabolites including geniposidic acid (M1), demethylation derivative of genipin-O-glucuronide (M2), and dehydration product of mono-hydroxylated genipin-O-glucuronide (M9) were only discovered in human urine. Further, the possible metabolic pathways of Fructus Gardeniae in vivo were proposed and the peak area–time curve of the most abundant metabolite genipin-O-glucuronide (M13) in human plasma after oral administration of Fructus Gardeniae was depicted. The results suggested that a metabolic difference existed between rats and humans. 3. The results obtained in the present research would provide basic information to understand the metabolic profile of Fructus Gardeniae in humans and explore the chemicals responsible for the hepatotoxicity of Fructus Gardeniae in vivo. Moreover, it would be beneficial for us to further study the pharmacokinetic behavior of Fructus Gardeniae in humans systematically.
Additional file 2 of Tolvaptan versus fluid restriction in acutely hospitalised patients with moderate-profound hyponatraemia (TVFR-HypoNa): design and implementation of an open-label randomised trial
Creators: name: Warren, Annabelle M.
name: Grossmann, Mathis
name: Hoermann, Rudolf
name: Zajac, Jeffrey D.
name: Russell, Nicholas
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 60506 Virology
subject: FOS: Biological sciences
subject: Computational Biology

description: Additional file 2: Appendix 2. Funding agreement with Otsuka Australia Pharmaceutical
Additional file 4 of Tolvaptan versus fluid restriction in acutely hospitalised patients with moderate-profound hyponatraemia (TVFR-HypoNa): design and implementation of an open-label randomised trial
Creators: name: Warren, Annabelle M.
name: Grossmann, Mathis
name: Hoermann, Rudolf
name: Zajac, Jeffrey D.
name: Russell, Nicholas
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 60506 Virology
subject: FOS: Biological sciences
subject: Computational Biology

description: Additional file 4: Appendix 4
Comparison of Medicaid spending in schizoaffective patients treated with once monthly paliperidone palmitate or oral atypical antipsychotics
Creators: name: Yongling Xiao
name: Muser, Erik
name: Dong-Jing Fu
name: Marie-Hélène Lafeuille
name: Pilon, Dominic
name: Emond, Bruno
name: Wu, Allen
name: Duh, Mei Sheng
name: Lefebvre, Patrick
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Background Compared to oral atypical antipsychotics (OAAs), long-acting injectable antipsychotics require less frequent administration, and thus may improve adherence and reduce risk of relapse in schizoaffective disorder (SAD) patients. Objective To evaluate the impact of once monthly paliperidone palmitate (PP) versus OAAs on healthcare resource utilization, Medicaid spending, and hospital readmission among SAD patients. Methods Using FL, IA, KS, MS, MO, and NJ Medicaid data (January 2009–December 2013), adults with ≥2 SAD diagnoses initiated on PP or OAA (index date) were identified. Baseline characteristics and outcomes were assessed during the 12month pre- and post-index periods, respectively. Propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) were used to reduce confounding and compare the estimated treatment effect for PP versus OAA. Results A total of 10,778 OAA-treated patients and 876 PP-treated patients were selected. Compared to OAAs, PP was associated with significantly lower medical costs (PSM: mean monthly cost difference [MMCD] = -$383, p p = 0.016), which offset the higher pharmacy costs associated with PP (PSM: MMCD = $270, p p p = 0.414; IPTW: MMCD = -$53, p = 0.697) for PP versus OAA. Reduced risk of hospitalization (PSM: incidence rate ratio [IRR] = 0.85, p = 0.128; IPTW: IRR = 0.96, p = 0.004) and fewer hospitalization days (PSM: IRR = 0.74, p = 0.008; IPTW: IRR = 0.85, p p = 0.041). Limitations The Medicaid data may not be representative of the nation or other states, and includes pre-rebate pharmacy costs (potentially over-estimated). Also changes in treatment over time were possible. Conclusions Total healthcare costs associated with the use of once monthly PP versus OAAs appeared comparable; higher pharmacy costs for PP users were offset by lower medical costs related to fewer and shorter inpatients visits.
Fossil marine vertebrates of Cerro Los Quesos: Distribution of cetaceans, seals, crocodiles, seabirds, sharks, and bony fish in a late Miocene locality of the Pisco Basin, Peru
Creators: name: Bianucci, Giovanni
name: Celma, Claudio Di
name: Collareta, Alberto
name: Landini, Walter
name: Post, Klaas
name: Tinelli, Chiara
name: Muizon, Christian De
name: Bosio, Giulia
name: Gariboldi, Karen
name: Gioncada, Anna
name: Malinverno, Elisa
name: Cantalamessa, Gino
name: Altamirano-Sierra, Ali
name: Salas-Gismondi, Rodolfo
name: Urbina, Mario
name: Lambert, Olivier
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: One-hundred and ninety-two fossil marine vertebrate specimens, preserved as bone elements cropping out at Cerro Los Quesos (Pisco Basin, Peru), are identified and reported on a 1:4,000 scale geological map and in the corresponding stratigraphic section. All the fossils originate from the Pisco Formation, which is dated in this area to the late Miocene (from 7.55 Ma to ≥6.71 Ma, based on 40Ar/39Ar analyses of three volcanic ash layers along the section). Specimens are particularly concentrated near the top of the two main hills, where the geologically youngest portion of the examined section crops out. The impressive fossil assemblage includes cetaceans (91.6%), represented by mysticetes (balaenopteroids and cetotheriids) and odontocetes (phocoenids, physeteroids, and ziphiids, including the holotype of Nazcacetus urbinai). Seals, a crocodile, a seabird, bony fish, and sharks are also reported. Isolated large teeth of Carcharocles and Cosmopolitodus are common and, in several instances, associated to mysticete skeletons. Together with a similar work recently published for the other late Miocene locality of Cerro Colorado, this work represents a case study for the detailed inventory of the extraordinary paleontological heritage of the Pisco Basin. As such, it constitutes the basis for future taphonomic, paleoecological, and systematic studies, as well as for a much-needed conservation effort.
Additional file 1 of Major adverse limb events in patients with femoro-popliteal and below-the-knee peripheral arterial disease treated with either sirolimus-coated balloon or standard uncoated balloon angioplasty: a structured protocol summary of the “SirPAD” randomized controlled trial
Creators: name: Barco, Stefano
name: Sebastian, Tim
name: Voci, Davide
name: Engelberger, Rolf Peter
name: Grigorean, Alexandru
name: Holy, Erik
name: Leeger, Claudia
name: Münger, Mario
name: Périard, Daniel
name: Probst, Eliane
name: Spescha, Rebecca
name: Held, Ulrike
name: Kucher, Nils
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: The latest version of the study protocol.
Additional file 1 of Implicit and explicit ethnic biases in multicultural primary care: the case of trainee general practitioners
Creators: name: Duveau, Camille
name: Demoulin, Stéphanie
name: Dauvrin, Marie
name: Lepièce, Brice
name: Lorant, Vincent
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 1: Appendix 1. List of words used for the Implicit Association Test. Appendix 2. Hudelson scale. Appendix 3. Correlation between IAT and Hudelson scale. Appendix 4. R² for each covariate.
BTEX exposures in an area impacted by industrial and mobile sources: Source attribution and impact of averaging time
Creators: name: Presto, Albert A.
name: Dallmann, Timothy R.
name: Peishi Gu
name: Unnati Rao
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Science Policy

description: The impacts of emissions plumes from major industrial sources on black carbon (BC) and BTEX (benzene, toluene, ethyl benzene, xylene isomers) exposures in communities located >10 km from the industrial source areas were identified with a combination of stationary measurements, source identification using positive matrix factorization (PMF), and dispersion modeling. The industrial emissions create multihour plume events of BC and BTEX at the measurement sites. PMF source apportionment, along with wind patterns, indicates that the observed pollutant plumes are the result of transport of industrial emissions under conditions of low boundary layer height. PMF indicates that industrial emissions contribute >50% of outdoor exposures of BC and BTEX species at the receptor sites. Dispersion modeling of BTEX emissions from known industrial sources predicts numerous overnight plumes and overall qualitative agreement with PMF analysis, but predicts industrial impacts at the measurement sites a factor of 10 lower than PMF. Nonetheless, exposures associated with pollutant plumes occur mostly at night, when residents are expected to be home but are perhaps unaware of the elevated exposure. Averaging data samples over long times typical of public health interventions (e.g., weekly or biweekly passive sampling) misapportions the exposure, reducing the impact of industrial plumes at the expense of traffic emissions, because the longer samples cannot resolve subdaily plumes. Suggestions are made for ways for future distributed pollutant mapping or intervention studies to incorporate high time resolution tools to better understand the potential impacts of industrial plumes. Implications: Emissions from industrial or other stationary sources can dominate air toxics exposures in communities both near the source and in downwind areas in the form of multihour plume events. Common measurement strategies that use highly aggregated samples, such as weekly or biweekly averages, are insensitive to such plume events and can lead to significant under apportionment of exposures from these sources.