cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Event-triggered robot self-assessment to aid in autonomy adjustment
Creators: name: Ahmed N.
name: Szafir D.
name: Conlon N.
Publisher: name: Frontiers Media SA
Year: 2023

description: Introduction: Human–robot teams are being called upon to accomplish increasingly complex tasks. During execution, the robot may operate at different levels of autonomy (LOAs), ranging from full robotic autonomy to full human control. For any number of reasons, such as changes in the robot’s surroundings due to the complexities of operating in dynamic and uncertain environments, degradation and damage to the robot platform, or changes in tasking, adjusting the LOA during operations may be necessary to achieve desired mission outcomes. Thus, a critical challenge is understanding when and how the autonomy should be adjusted. Methods: We frame this problem with respect to the robot’s capabilities and limitations, known as robot competency. With this framing, a robot could be granted a level of autonomy in line with its ability to operate with a high degree of competence. First, we propose a Model Quality Assessment metric, which indicates how (un)expected an autonomous robot’s observations are compared to its model predictions. Next, we present an Event-Triggered Generalized Outcome Assessment (ET-GOA) algorithm that uses changes in the Model Quality Assessment above a threshold to selectively execute and report a high-level assessment of the robot’s competency. We validated the Model Quality Assessment metric and the ET-GOA algorithm in both simulated and live robot navigation scenarios. Results: Our experiments found that the Model Quality Assessment was able to respond to unexpected observations. Additionally, our validation of the full ET-GOA algorithm explored how the computational cost and accuracy of the algorithm was impacted across several Model Quality triggering thresholds and with differing amounts of state perturbations. Discussion: Our experimental results combined with a human-in-the-loop demonstration show that Event-Triggered Generalized Outcome Assessment algorithm can facilitate informed autonomy-adjustment decisions based on a robot’s task competency.
title: Charges de neige sur les toitures
Creators: name: Peter, B. G.
name: Schriever, W. R.
Publisher: name: Conseil national de recherches du Canada. Division des recherches en construction
Year: 1963
Subjects: subject: Snow and Ice loads
valueUri: urn:ircsubjects:IRC0373
subject: Surcharges neige et glace
valueUri: urn:ircsubjects:IRC0373
subject: roofing
subject: couvertures
subject: roofs
subject: toîture
subject: snow loads
subject: surcharges de neige
subject: design loads
subject: charge utile

description: Dans de nombreux cas, les charge de neige constituent la principale préoccupation en ce qui concerne les toitures. On doit donc faire une estimation très soigneuse de la charge de neige afin de réduire les coûts de construction et les risques de rupture.
Sister-species of eastern Pacific hydrothermal vent worms (Ampharetidae, Alvinellidae, Vestimentifera) provide
new mitochondrial COI clock calibration
Creators: name: CHEVALDONNÉ, Pierre
name: JOLLIVET, Didier
name: DESBRUYÈRES, Daniel
name: LUTZ 4 VRIJENHOEK, Richard A. And Robert C.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2002

Abstract
(3958) Janet Leitch
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Biochemical Analysis of the Human Mismatch Repair Proteins hMutSα MSH 2 G674A -MSH6 and MSH2-MSH6 T1219D
Creators: name: Yamane, Kazuhiko
name: Hingorani, Manju
name: Sakato, Miho
name: Geng, Hui
name: Hsieh, Peggy
name: Erie, Dorothy A.
name: DeRocco, Vanessa
name: Du, Chunwei
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The heterodimeric human MSH2-MSH6 protein initiates DNA mismatch repair (MMR) by recognizing mismatched bases that result from replication errors. Msh2G674A or Msh6T1217D mice that have mutations in or near the ATP binding site of MSH2 or ATP hydrolysis catalytic site of MSH6 develop cancer and have a reduced lifespan due to loss of the MMR pathway (Lin, D. P., Wang, Y., Scherer, S. J., Clark, A. B., Yang, K., Avdievich, E., Jin, B., Werling, U., Parris, T., Kurihara, N., Umar, A., Kucherlapati, R., Lipkin, M., Kunkel, T. A., and Edelmann, W. (2004) Cancer Res. 64, 517–522; Yang, G., Scherer, S. J., Shell, S. S., Yang, K., Kim, M., Lipkin, M., Kucherlapati, R., Kolodner, R. D., and Edelmann, W. (2004) Cancer Cell 6, 139–150). Mouse embryonic fibroblasts from these mice retain an apoptotic response to DNA damage. Mutant human MutSα proteins MSH2G674A-MSH6wt and MSH2wt-MSH6T1219D are profiled in a variety of functional assays and as expected fail to support MMR in vitro, although they retain mismatch recognition activity. Kinetic analyses of DNA binding and ATPase activities and examination of the excision step of MMR reveal that the two mutants differ in their underlying molecular defects. MSH2wt-MSH6T1219D fails to couple nucleotide binding and mismatch recognition, whereas MSH2G674A-MSH6wt has a partial defect in nucleotide binding. Nevertheless, both mutant proteins remain bound to the mismatch and fail to promote efficient excision thereby inhibiting MMR in vitro in a dominant manner. Implications of these findings for MMR and DNA damage signaling by MMR proteins are discussed.
title: Isolation thermique des maisons d'habitation
Creators: name: Ball, W. H.
Publisher: name: Conseil national de recherches du Canada. Division des recherches en construction
Year: 1963
Subjects: subject: Insulation
valueUri: urn:ircsubjects:IRC0350
subject: Isolation
valueUri: urn:ircsubjects:IRC0350
subject: roofing
subject: couvertures
subject: thermal insulation
subject: isolation thermique
subject: wood construction
subject: construction en bois
subject: masonry construction
subject: construction de maçonnerie
subject: installation (activity)
subject: travaux d'installation
subject: attics
subject: grenier
subject: flat roofs
subject: toiture terrasse
subject: crawl spaces
subject: vide sanitaire
subject: flat slab floors
subject: plancher dalle

description: Ce Digeste passe en revue un certain nombre de détails relatifs à l'emploi et à l'installation des garnitures isolantes.
title: Snow loads on roofs
Creators: name: Peter, B. G.
name: Schriever, W. R.
Publisher: name: National Research Council of Canada. Division of Building Research
Year: 1963
Subjects: subject: Snow and Ice loads
valueUri: urn:ircsubjects:IRC0373
subject: Surcharges neige et glace
valueUri: urn:ircsubjects:IRC0373
subject: roofing
subject: couvertures
subject: roofs
subject: toîture
subject: snow loads
subject: surcharges de neige
subject: design loads
subject: charge utile

description: In many cases snow loads constitute the largest design load for the roof system. A careful assessment of the snow load is required, therefore, to avoid both unnecessary construction costs and undue risk of failure.
(3960) Annie Stark Leitch
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 2 of Facilitators and barriers influencing weight management behaviours during pregnancy: a meta-synthesis of qualitative research
Creators: name: Escañuela Sánchez, Tamara
name: Meaney, Sarah
name: O’Connor, Caroline
name: Linehan, Laura
name: O’Donoghue, Keelin
name: Byrne, Molly
name: Matvienko-Sikar, Karen
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2.
Biological and Structural Characterization of Trypanosoma cruzi Phosphodiesterase C and Implications for Design of Parasite Selective Inhibitors
Creators: name: Robinson, Howard
name: Seebeck, Thomas
name: Kunz, Stefan
name: Martinelli, Sibylla
name: Wang, Huanchen
name: Chen, Gong
name: Wan, Yiqian
name: Ke, Hengming
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Trypanosoma cruzi phosphodiesterase C (TcrPDEC) is a potential new drug target for the treatment of Chagas disease but has not been well studied. This study reports the enzymatic properties of various kinetoplastid PDECs and the crystal structures of the unliganded TcrPDEC1 catalytic domain and its complex with an inhibitor. Mutations of PDEC during the course of evolution led to inactivation of PDEC in Trypanosoma brucei/Trypanosoma evansi/Trypanosoma congolense, whereas the enzyme is active in all other kinetoplastids. The TcrPDEC1 catalytic domain hydrolyzes both cAMP and cGMP with a Km of 23.8 μm and a kcat of 31 s−1 for cAMP and a Km of 99.1 μm and a kcat of 17 s−1 for cGMP, thus confirming its dual specificity. The crystal structures show that the N-terminal fragment wraps around the TcrPDEC catalytic domain and may thus regulate its enzymatic activity via direct interactions with the active site residues. A PDE5 selective inhibitor that has an IC50 of 230 nm for TcrPDEC1 binds to TcrPDEC1 in an orientation opposite to that of sildenafil. This observation, together with the screen of the inhibitory potency of human PDE inhibitors against TcrPDEC, implies that the scaffold of some human PDE inhibitors might be used as the starting model for design of parasite PDE inhibitors. The structural study also identified a unique parasite pocket that neighbors the active site and may thus be valuable for the design of parasite-specific inhibitors.
Statistics of two-dimensional random walks, the "cyclic sieving phenomenon" and the Hofstadter model
Creators: name: Mashkevich, Stefan
name: Ouvry, Stéphane
name: Polychronakos, Alexios
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We focus on the algebraic area probability distribution of planar random walks on a square lattice with $m_1$, $m_2$, $l_1$ and $l_2$ steps right, left, up and down. We aim, in particular, at the algebraic area generating function $Z_{m_1,m_2,l_1,l_2}(Q)$ evaluated at $Q=e^{2ıπ\over q}$, a root of unity, when both $m_1-m_2$ and $l_1-l_2$ are multiples of $q$. In the simple case of staircase walks, a geometrical interpretation of $Z_{m,0,l,0}(e^\frac{2iπ}{q})$ in terms of the cyclic sieving phenomenon is illustrated. Then, an expression for $Z_{m_1,m_2,l_1,l_2}(-1)$, which is relevant to the Stembridge's case, is proposed. Finally, the related problem of evaluating the n-th moments of the Hofstadter Hamiltonian in the commensurate case is addressed.
description: 13 pages, LaTeX 2e
Additional file 1 of Facilitators and barriers influencing weight management behaviours during pregnancy: a meta-synthesis of qualitative research
Creators: name: Escañuela Sánchez, Tamara
name: Meaney, Sarah
name: O’Connor, Caroline
name: Linehan, Laura
name: O’Donoghue, Keelin
name: Byrne, Molly
name: Matvienko-Sikar, Karen
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1.
BMPER Protein Is a Negative Regulator of Hepcidin and Is Up-regulated in Hypotransferrinemic Mice
Creators: name: Patel, Neeta
name: Jacob, Molly
name: McKiea, Andrew T.
name: Simpson, Robert J.
name: Qureshi, Aakafa
name: Masaratana, Patarabutr
name: Hughes, Robin D.
name: Diaz-Castro, Javier
name: Patterson, Cam
name: Dhawan, Anil
name: Arno, Matthew
name: Mitry, Ragai R.
name: Lockyer, Pamela
name: Latunde-Dada, Gladys O.
name: Matak, Pavle
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The BMP/SMAD4 pathway has major effects on liver hepcidin levels. Bone morphogenetic protein-binding endothelial cell precursor-derived regulator (Bmper), a known regulator of BMP signaling, was found to be overexpressed at the mRNA and protein levels in liver of genetically hypotransferrinemic mice (Trfhpx/hpx). Soluble BMPER peptide inhibited BMP2- and BMP6-dependent hepcidin promoter activity in both HepG2 and HuH7 cells. These effects correlated with reduced cellular levels of pSMAD1/5/8. Addition of BMPER peptide to primary human hepatocytes abolished the BMP2-dependent increase in hepcidin mRNA, whereas injection of Bmper peptide into mice resulted in reduced liver hepcidin and increased serum iron levels. Thus Bmper may play an important role in suppressing hepcidin production in hypotransferrinemic mice.
Characterization of Δ N-Zfp36l2 Mutant Associated with Arrest of Early Embryonic Development and Female Infertility
Creators: name: Ramos, Silvia B.V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The zinc finger protein 36-like 2, Zfp36l2, has been implicated in female mouse infertility, because an amino-terminal truncation mutation (ΔN-Zfp36l2) leads to two-cell stage arrest of embryos derived from the homozygous mutant female gamete. Zfp36l2 is a member of the tristetraprolin (TTP) family of CCCH tandem zinc finger proteins that can bind to transcripts containing AU-rich elements (ARE), resulting in deadenylation and destabilization of these transcripts. I show here that the mouse Zfp36l2 is composed of two exons and a single intron, encoding a polypeptide of 484 amino acids. I observed that ΔN-Zfp36l2 protein is similar to both wild-type Zfp36l2 and TTP (Zfp36) in that it shuttles between the cytoplasm and nucleus, binds to RNAs containing AREs, and promotes deadenylation of a model ARE transcript in a cell-based co-transfection assay. Surprisingly, in contrast to TTP, Zfp36l2 mRNA and protein were rapidly down-regulated upon LPS exposure in bone marrow-derived macrophages. The ΔN-Zfp36l2 protein was substantially more resistant to stimulus-induced down-regulation than the WT. I postulate that the embryonic arrest linked to the ΔN-Zfp36l2 truncation might be related to its resistance to stimulus-induced down-regulation.
(3956) Mary Aughterson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
How Damage Diversification Can Reduce Systemic Risk
Creators: name: Burkholz, Rebekka
name: Garas, Antonios
name: Schweitzer, Frank
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences

description: We consider the problem of risk diversification in complex networks. Nodes represent e.g. financial actors, whereas weighted links represent e.g. financial obligations (credits/debts). Each node has a risk to fail because of losses resulting from defaulting neighbors, which may lead to large failure cascades. Classical risk diversification strategies usually neglect network effects and therefore suggest that risk can be reduced if possible losses (i.e., exposures) are split among many neighbors (exposure diversification, ED). But from a complex networks perspective diversification implies higher connectivity of the system as a whole which can also lead to increasing failure risk of a node. To cope with this, we propose a different strategy (damage diversification, DD), i.e. the diversification of losses that are imposed on neighboring nodes as opposed to losses incurred by the node itself. Here, we quantify the potential of DD to reduce systemic risk in comparison to ED. For this, we develop a branching process approximation that we generalize to weighted networks with (almost) arbitrary degree and weight distributions. This allows us to identify systemically relevant nodes in a network even if their directed weights differ strongly. On the macro level, we provide an analytical expression for the average cascade size, to quantify systemic risk. Furthermore, on the meso level we calculate failure probabilities of nodes conditional on their system relevance.
Chemoenzymatic Synthesis of Heparin Oligosaccharides with both Anti-factor Xa and Anti-factor IIa Activities
Creators: name: Pempe, Elizabeth H.
name: Liu, Jian
name: Xu, Yongmei
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Heparan sulfate (HS) and heparin are highly sulfated polysaccharides. Heparin is a commonly used anticoagulant drug that inhibits the activities of factors Xa and IIa (also known as thrombin) to prevent blood clot formation. Here, we report the synthesis of a series of size-defined oligosaccharides to probe the minimum size requirement for an oligosaccharide with anti-IIa activity. The synthesis was completed by a chemoenzymatic approach involving glycosyltransferases, HS sulfotransferases, and C5-epimerase. We demonstrate the ability to synthesize highly purified N-sulfo-oligosaccharides having up to 21 saccharide residues. The results from anti-Xa and anti-IIa activity measurements revealed that an oligosaccharide longer than 19 saccharide residues is necessary to display anti-IIa activity. The oligosaccharides also exhibit low binding toward platelet factor 4, raising the possibility of preparing a synthetic heparin with a reduced effect of heparin-induced thrombocytopenia. The results from this study demonstrate the ability to synthesize large HS oligosaccharides and provide a unique tool to probe the structure and function relationships of HS that require the use of large HS fragments.
Diet of European conger eel Conger conger (Osteichthyes: Congridae) from the northeastern coast of Tunisia (central Mediterranean)
Creators: name: SALLAMI, Balkis
name: BEN SALEM, Mohamed
name: REYNAUD, Christian
name: CAPAPÉ, Christian
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2015

description: Diet of European conger eel Conger conger (Linnaeus, 1758) was studied in relation to size and seasons from specimens collected off the northeastern coast of Tunisia. Of the 288 sampled specimens, 24 were immature, 9 males and 255 females. The relationship total length (TL) versus total body mass (TBW) showed a positive allometry, suggesting that C. conger found favourable environmental parameters and available preys in its habitat. Vacuity index (VI) high values for total sample and also related to size classes and to seasons. Seventeen families and 25 species were consumed by C. conger; osteichthyan preys were the most abundant in stomach contents comprising 11 families and 16 species, representing 72.99% of number (%N), 84.65% of weight (%W), 78.16% of frequency (%F), 94.59% as percent of the index of relative importance (%IRI). Crustaceans were the second preferential preys ingested by C. conger represented by 3 families and at least 5 species with %IRI = 4.77, cephalopods and polychaetes were occasional preys, whereas seagrass accidentally ingested. C. conger is a piscivorous species and cannibalism was also recorded in its diet. The calculated trophic level, TROPH, was 4.15 (SE = 0.72), and did not display significant changes linked to size and seasons. This high value of TROPH showed that C. conger is a carnivorous species with preference to osteichthyan and crustacean species and therefore a top predator.
Additional file 3 of Facilitators and barriers influencing weight management behaviours during pregnancy: a meta-synthesis of qualitative research
Creators: name: Escañuela Sánchez, Tamara
name: Meaney, Sarah
name: O’Connor, Caroline
name: Linehan, Laura
name: O’Donoghue, Keelin
name: Byrne, Molly
name: Matvienko-Sikar, Karen
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 3.
Transient eddy current flow metering
Creators: name: Forbriger, Jan
name: Stefani, Frank
Publisher: name: arXiv
Year: 2015
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Measuring local velocities or entire flow rates in liquid metals or semiconductor melts is a notorious problem in many industrial applications, including metal casting and silicon crystal growth. We present a new variant of an old technique which relies on the continuous tracking of a flow-advected transient eddy current that is induced by a pulsed external magnetic field. This calibration-free method is validated by applying it to the velocity of a spinning disk made of aluminum. First tests at a rig with a flow of liquid GaInSn are also presented.
description: 11 pages, 11 figures
Weighted Approach for Estimating Effects in Principal Strata With Missing Data for a Categorical Post-Baseline Variable in Randomized Controlled Trials
Creators: name: Kong, Shengchun
name: Heinzmann, Dominik
name: Lauer, Sabine
name: Tian, Lu
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Computational Biology

description: This research was motivated by studying anti-drug antibody (ADA) formation and its potential impact on long-term benefit of a biologic treatment in a randomized controlled trial, in which ADA status was not only unobserved in the control arm but also in a subset of patients from the experimental treatment arm. Recent literature considers the principal stratum estimand strategy to estimate treatment effect in groups of patients defined by an intercurrent status, that is, in groups defined by a post-randomization variable only observed in one arm and potentially associated with the outcome. However, status information might be missing even for a nonnegligible number of patients in the experimental arm. For this setting, a novel weighted principal stratum approach, namely weighted imputation regression (WRI), is presented: Data from patients with missing intercurrent event status were re-weighted based on baseline covariates and additional longitudinal information. A theoretical justification of the WRI method is provided for different types of outcomes, and assumptions allowing for causal conclusions on treatment effect are specified and investigated. Simulations demonstrated that the WRI method yielded valid inference and was robust against certain violations of assumptions. The method was shown to perform well in a clinical study with ADA status as an intercurrent event.
Federally Qualified Health Centers Use of Telehealth to Deliver Integrated Behavioral Health Care During COVID-19
Creators: name: Greeno C.
name: Lombardi B.M.
name: de Saxe Zerden L.
Publisher: name: Springer
Year: 2024

description: Federally qualified health centers (FQHCs) that provide comprehensive health services, including integrated behavioral health (IBH), transitioned to deliver care via telehealth during the COVID-19 pandemic. This study explored how FQHCs adapted IBH services using telehealth. A mixed-method design was used, pairing a survey disseminated to FQHC administrators with a structured interview. Of the 46 administrators who participated in the survey, 14 (30.4%) reported delivering IBH using telecommunication prior to the pandemic. Since COVID-19, almost all of the FQHCs surveyed used telecommunication to deliver IBH (n = 44, 95.7%). Nine interviews with FQHC administrators resulted in the four themes: telehealth was essential; core components of IBH were impacted; payment parity and reimbursement were a concern; and telehealth addressed workforce issues. Findings confirm the necessity of telehealth for FQHCs during COVID-19. However due to the lack of co-location, warm-handoffs and other core components of IBH were limited.
Flavour Changing Higgs Couplings in a Class of Two Higgs Doublet Models
Creators: name: Botella, F. J.
name: Branco, G. C.
name: Nebot, M.
name: Rebelo, M. N.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We analyse various flavour changing processes like $t\to hu,hc$, $h\to τe,τμ$ as well as hadronic decays $h\to bs,bd$, in the framework of a class of two Higgs doublet models where there are flavour changing neutral scalar currents at tree level. These models have the remarkable feature of having these flavour-violating couplings entirely determined by the CKM and PMNS matrices as well as $\tanβ$. The flavour structure of these scalar currents results from a symmetry of the Lagrangian and therefore it is natural and stable under the renormalization group. We show that in some of the models the rates of the above flavour changing processes can reach the discovery level at the LHC at 13 TeV even taking into account the stringent bounds on low energy processes, in particular $μ\to eγ$.
description: 33 pages, 8 figures; matches version accepted for publication
Occurrence of the lessepsian species Portunus segnis (Crustacea: Decapoda) in the Gulf of Gabes (Tunisia): first record and new information on its biology and ecology
Creators: name: RABAOUI, Lotfi
name: ARCULEO, Marco
name: MANSOUR, Lamjed
name: TLIG-ZOUARI, Sabiha
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2015

description: The alien blue swimming crab, Portunus segnis (Forskål, 1775), an Indo-Pacific species has been recorded in the Southern Mediterranean Sea since decades, even if its occurrence along the Tunisian coasts was not recorded yet. This paper reports the first record of P. segnis in the Gulf of Gabes, south-eastern Tunisia, with few observations on its biology and ecology. Twenty-four females of P. segnis were accidentally caught by local fishermen in October 2014 in shallow sandy areas covered mostly by seagrass and algal beds. Among these 24 individuals, 14 specimens (58.33%) were ovigerous. The mean carapace length (CL) and width (CW) of ovigerous females were 143.0 ± 5.8 mm and 67.8 ± 3.6 mm respectively, whereas in non ovigerous females these were 127.3 ± 6.8 mm and 58.9 ± 4.2 mm, respectively. The relationships between the size (CW and CL) and weight (TW) for ovigerous and non ovigerous females were also examined with non-linear equations. In addition, the mean number of eggs (fecundity) of 12 ovigerous females (whose mean CW = 143.3 ± 6.2 mm) was 777642 ± 80684. The correlations between fecundity and both CW and TW were found to be statistically significant.
A new method for estimating the pattern speed of spiral structure in the Milky Way
Creators: name: Junqueira, T. C.
name: Chiappini, C.
name: Lépine, J. R. D.
name: Minchev, I.
name: Santiago, B. X.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: In the last few decades many efforts have been made to understand the effect of spiral arms on the gas and stellar dynamics in the Milky Way disc. One of the fundamental parameters of the spiral structure is its angular velocity, or pattern speed $Ω_p$, which determines the location of resonances in the disc and the spirals' radial extent. The most direct method for estimating the pattern speed relies on backward integration techniques, trying to locate the stellar birthplace of open clusters. Here we propose a new method based on the interaction between the spiral arms and the stars in the disc. Using a sample of around 500 open clusters from the {\it New Catalogue of Optically Visible Open Clusters and Candidates}, and a sample of 500 giant stars observed by APOGEE, we find $Ω_p = 23.0\pm0.5$ km s$^{-1}$ kpc$^{-1}$, for a local standard of rest rotation $V_0=220$~km s$^{-1}$ and solar radius $R_0=8.0$~kpc. Exploring a range in $V_0$ and $R_0$ within the acceptable values, 200-240 km s$^{-1}$ and 7.5-8.5 kpc, respectively, results only in a small change in our estimate of $Ω_p$, that is within the error. Our result is in close agreement with a number of studies which suggest values in the range 20-25 km s$^{-1}$ kpc$^{-1}$. An advantage of our method is that we do not need knowledge of the stellar age, unlike in the case of the birthplace method, which allows us to use data from large Galactic surveys. The precision of our method will be improved once larger samples of disk stars with spectroscopic information will become available thanks to future surveys such as 4MOST.
description: 10 pages, 6 figures, 4 tables, accepted for publication in MNRAS
Additional file 4 of Facilitators and barriers influencing weight management behaviours during pregnancy: a meta-synthesis of qualitative research
Creators: name: Escañuela Sánchez, Tamara
name: Meaney, Sarah
name: O’Connor, Caroline
name: Linehan, Laura
name: O’Donoghue, Keelin
name: Byrne, Molly
name: Matvienko-Sikar, Karen
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 4.
title: Dielectric Mie voids : confining light in air
Creators: name: Hentschel, Mario
name: Koshelev, Kirill
name: Sterl, Florian
name: Both, Steffen
name: Karst, Julian
name: Shamsafar, Lida
name: Weiss, Thomas
name: Kivshar, Yuri
name: Giessen, Harald
Publisher: name: Universität Stuttgart
Year: 2023
Subjects: subject: 530

description: Manipulating light on the nanoscale has become a central challenge in metadevices, resonant surfaces, nanoscale optical sensors, and many more, and it is largely based on resonant light confinement in dispersive and lossy metals and dielectrics. Here, we experimentally implement a novel strategy for dielectric nanophotonics: Resonant subwavelength localized confinement of light in air. We demonstrate that voids created in high-index dielectric host materials support localized resonant modes with exceptional optical properties. Due to the confinement in air, the modes do not suffer from the loss and dispersion of the dielectric host medium. We experimentally realize these resonant Mie voids by focused ion beam milling into bulk silicon wafers and experimentally demonstrate resonant light confinement down to the UV spectral range at 265 nm (4.68 eV). Furthermore, we utilize the bright, intense, and naturalistic colours for nanoscale colour printing. Mie voids will thus push the operation of functional high-index metasurfaces into the blue and UV spectral range. The combination of resonant dielectric Mie voids with dielectric nanoparticles will more than double the parameter space for the future design of metasurfaces and other micro- and nanoscale optical elements. In particular, this extension will enable novel antenna and structure designs which benefit from the full access to the modal field inside the void as well as the nearly free choice of the high-index material for novel sensing and active manipulation strategies.
Halacaridae (Arachnida: Acari) from Lost City, the Mid-Atlantic Ridge, description of new species
Creators: name: BARTSCH, Ilse
name: RYBAKOVA, Elena
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2015

description: Six halacarid species have been extracted from the coldwater hydrothermal field Lost City on the Mid-Atlantic Ridge, 30°N. The species belong to the genera Copidognathus (one species), Scaptognathus (two species), Simognathus (one species), and Thalassarachna (two species). Three new species are described, namely Copidognathus calidictyotus sp. nov., Thalassarachna mollis sp. nov. and Thalassarachna setulosa sp. nov., the characters of the Scaptognathus and Simognathus species are outlined. Copidognathus calidictyotus has been the most abundant species.
Estimands and their Estimators for Clinical Trials Impacted by the COVID-19 Pandemic: A Report from the NISS Ingram Olkin Forum Series on Unplanned Clinical Trial Disruptions
Creators: name: Van Lancker, Kelly
name: Tarima, Sergey
name: Bartlett, Jonathan
name: Bauer, Madeline
name: Bharani-Dharan, Bharani
name: Bretz, Frank
name: Flournoy, Nancy
name: Michiels, Hege
name: Parra, Camila Olarte
name: Rosenberger, James L.
name: Cro, Suzie
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy

description: The COVID-19 pandemic continues to affect the conduct of clinical trials globally. Complications may arise from pandemic-related operational challenges such as site closures, travel limitations and interruptions to the supply chain for the investigational product, or from health-related challenges such as COVID-19 infections. Some of these complications lead to unforeseen intercurrent events in the sense that they affect either the interpretation or the existence of the measurements associated with the clinical question of interest. In this article, we demonstrate how the ICH E9(R1) Addendum on estimands and sensitivity analyses provides a rigorous basis to discuss potential pandemic-related trial disruptions and to embed these disruptions in the context of study objectives and design elements. We introduce several hypothetical estimand strategies and review various causal inference and missing data methods, as well as a statistical method that combines unbiased and possibly biased estimators for estimation. To illustrate, we describe the features of a stylized trial, and how it may have been impacted by the pandemic. This stylized trial will then be revisited by discussing the changes to the estimand and the estimator to account for pandemic disruptions. Finally, we outline considerations for designing future trials in the context of unforeseen disruptions.
(3959) Mary Oughterson Leitch
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Context Surrounding Processing Sites Is Crucial in Determining Cleavage Rate of a Subset of Processing Sites in HIV-1 Gag and Gag-Pro-Pol Polyprotein Precursors by Viral Protease
Creators: name: Özen, Ayşegül
name: Swanstrom, Ronald
name: Kolli, Madhavi
name: Potempa, Marc
name: Schiffer, Celia A.
name: Lee, Sook Kyung
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Processing of the human immunodeficiency virus type 1 (HIV-1) Gag and Gag-Pro-Pol polyproteins by the HIV-1 protease (PR) is essential for the production of infectious particles. However, the determinants governing the rates of processing of these substrates are not clearly understood. We studied the effect of substrate context on processing by utilizing a novel protease assay in which a substrate containing HIV-1 matrix (MA) and the N-terminal domain of capsid (CA) is labeled with a FlAsH (fluorescein arsenical hairpin) reagent. When the seven cleavage sites within the Gag and Gag-Pro-Pol polyproteins were placed at the MA/CA site, the rates of cleavage changed dramatically compared with that of the cognate sites in the natural context reported previously. The rate of processing was affected the most for three sites: CA/spacer peptide 1 (SP1) (≈10-fold increase), SP1/nucleocapsid (NC) (≈10–30-fold decrease), and SP2/p6 (≈30-fold decrease). One of two multidrug-resistant (MDR) PR variants altered the pattern of processing rates significantly. Cleavage sites within the Pro-Pol region were cleaved in a context-independent manner, suggesting for these sites that the sequence itself was the determinant of rate. In addition, a chimera consisting of SP1/NC P4–P1 and MA/CA P1′–P4′ residues (ATIM↓PIVQ) abolished processing by wild type and MDR proteases, and the reciprocal chimera consisting of MA/CA P4–P1 and SP1/NC P1′–4′ (SQNY↓IQKG) was cleaved only by one of the MDR proteases. These results suggest that complex substrate interactions both beyond the active site of the enzyme and across the scissile bond contribute to defining the rate of processing by the HIV-1 PR.
Deciphering Mode of Action of Heparanase Using Structurally Defined Oligosaccharides
Creators: name: Liu, Jian
name: Peterson, Sherket
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Heparan sulfate (HS) is a highly sulfated polysaccharide that serves many biological functions, including regulating cell growth and inflammatory responses as well as the blood coagulation process. Heparanase is an enzyme that cleaves HS and is known to display a variety of pathophysiological effects in cancer, diabetes, and Alzheimer disease. The link between heparanase and diseases is a result of its selective cleavage of HS, which releases smaller HS fragments to enhance cell proliferation, migration, and invasion. Despite its importance in pathological diseases, the structural cues in HS that direct heparanase cleavage and the steps of HS depolymerization remain unknown. Here, we sought to probe the substrate specificity of heparanase using a series of structurally defined oligosaccharide substrates. The sites of heparanase cleavage on the oligosaccharide substrates were determined by mass spectrometry and gel permeation chromatography. We discovered that heparanase cleaves the linkage of glucuronic acid linked to glucosamine carrying 6-O-sulfo groups. Furthermore, our findings suggest that heparanase displays different cleavage modes by recognizing the structures of the nonreducing ends of the substrates. Our results deepen the understanding of the action mode of heparanase.
(3954) Clement Ernest Osborne
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Phosphodiester amine, taurine and derivatives, and other osmolytes in Vesicomyid bivalves: correlations with depth and symbiont metabolism
Creators: name: FIESS, Jeanette C.
name: HUDSON, Hilary A.
name: HOM, Jennifer R.
name: KATO, Chiaki
name: YANCEY, Paul H.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2002

Abstract
Relativistic electron transport through an oscillating barrier: wave packet generation and Fano-type resonances
Creators: name: Szabó, Lóránt Zs.
name: Benedict, Mihály G.
name: Czirják, Attila
name: Földi, Péter
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Transport properties of massive Dirac particles are investigated through an oscillating barrier. The Floquet quasienergies related to the time-dependent potential appear both in transmission and reflection as sidebands around the incoming electron's energy. We take all relevant sidebands into account and present time averaged transmission and reflection probabilities in a wide energy range. Most qualitative features of scattering on a static barrier -- like Klein paradox -- are still visible, but the transmission probability in the evanescent regime observably increases due to the oscillation of the potential. The strongly inelastic scattering process is shown to lead to multiple Fano-type resonances and temporal trapping of the particles inside the oscillating potential. We also present a detailed study of the time evolution of the wave packets generated in the scattering process. Our results can be relevant for graphene with an induced energy gap.
Radial velocities and metallicities from infrared Ca II triplet spectroscopy of open clusters II. Berkeley 23, King 1, NGC 559, NGC 6603 and NGC 7245
Creators: name: Carrera, R.
name: Casamiquela, L.
name: Ospina, N.
name: Balaguer-Nuñez, L.
name: Jordi, C.
name: Monteagudo, L.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Context: Open clusters are key to studying the formation and evolution of the Galactic disc. However, there is a deficiency of radial velocity and chemical abundance determinations for open clusters in the literature. Aims: We intend to increase the number of determinations of radial velocities and metallicities from spectroscopy for open clusters. Methods: We acquired medium-resolution spectra (R~8000) in the infrared region Ca II triplet lines (~8500 AA) for several stars in five open clusters with the long-slit IDS spectrograph on the 2.5~m Isaac Newton Telescope (Roque de los Muchachos Observatory, Spain). Radial velocities were obtained by cross-correlation fitting techniques. The relationships available in the literature between the strength of infrared Ca II lines and metallicity were also used to derive the metallicity for each cluster. Results: We obtain = 48.6+/-3.4, -58.4+/-6.8, 26.0+/-4.3 and -65.3+/-3.2 km s-1 for Berkeley 23, NGC 559, NGC 6603 and NGC 7245, respectively. We found [Fe/H] =-0.25+/-0.14 and -0.15+/-0.18 for NGC 559 and NGC 7245, respectively. Berkeley 23 has a low metallicity, [Fe/H] =-0.42+/-0.13, similar to other open clusters in the outskirts of the Galactic disc. In contrast, we derived a high metallicity ([Fe/H] =+0.43+/-0.15) for NGC 6603, which places this system among the most metal rich known open clusters. To our knowledge, this is the first determination of radial velocities and metallicities from spectroscopy for these clusters, except NGC 6603, for which radial velocities had been previously determined. We have also analysed ten stars in the line of sight to King 1. Because of the large dispersion obtained in both radial velocity and metallicity, we cannot be sure that we have sampled true cluster members.
description: 10 pages, 5 figures, accepted for publication in A&A (minor modifications)
(3955) William Leitch
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Rejoinder: Estimands and their Estimators for Clinical Trials Impacted by the COVID-19 Pandemic: A Report from the NISS Ingram Olkin Forum Series on Unplanned Clinical Trial Disruptions
Creators: name: Van Lancker, Kelly
name: Tarima, Sergey
name: Bartlett, Jonathan
name: Bauer, Madeline
name: Bharani-Dharan, Bharani
name: Bretz, Frank
name: Flournoy, Nancy
name: Michiels, Hege
name: Parra, Camila Olarte
name: Rosenberger, James L
name: Cro, Suzie
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Rejoinder: Estimands and their Estimators for Clinical Trials Impacted by the COVID-19 Pandemic: A Report from the NISS Ingram Olkin Forum Series on Unplanned Clinical Trial Disruptions