cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Molecular characterization of the MAN antigens.
Creators: name: Blake, Deborah L.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Biology, Molecular.

description: The nuclear lamina consists of a filamentous network of proteins situated beneath the inner nuclear membrane and apposed to peripheral chromatin. As a consequence of its location, the nuclear lamina has been proposed to be involved in a number of different cellular functions. I have used a human antiserum to further characterize a novel set of nuclear lamina proteins, termed the MAN antigens. These antigens comprise three major polypeptides with relative mobilities of 78, 58 and 40 kDa. During interphase, the MAN antigens co-localized with the lamins at the nuclear periphery, but were absent from intranuclear foci of lamin B. In cells which possessed micronuclei, both the MAN antigens and lamins A/C were observed to segregate within these structures, separate from lamin B. Through mitosis, lamins A/C were seen to disassemble in late prophase and reassemble in telophase. Conversely, lamin B and the MAN antigens began to disassemble only during late prometaphase and then reformed around segregating chromosomes in anaphase, prior to lamins A/C. The human antiserum was used to screen a P19 embryonal carcinoma cDNA expression library for clones which encoded polypeptides immunologically related to the MAN antigens. (Abstract shortened by UMI.)
Describe and estimate kinetic energy transfers in 3D-turbulent planetary atmospheres
Creators: name: Cabanes
name: Galperin
name: Espa
name: Spiga
name: , Young
name: Read
Publisher: name: Zenodo
Year: 2020
Subjects: Planetary turbulence
zonal jets
Global Climate Modeling

description: This talk has been presented at Sorbonne université and Ecole Normale Supérieure de Paris in November 2019 with the following abstract: Images of the giant planets, Jupiter, Saturn and other exoplanets, show highly turbulent storms and swirling clouds that are reflecting the strength of the energetic power enclosed in those planets. Yet, the energetic power of planetary turbulence is inaccessible to conventional tools that require a large amount of data and high resolution two-dimensional maps of the wind field. Here we show that potential vorticity offers a straightforward and universal diagnostic to estimate the global energetic budget in planets. We rely on the conservation of the potential vorticity in stably stratified rotating system to define a length scale, denoted LM , that is the typical distance on which potential vorticity is mixed by planetary turbulence. LM increases with the energetic power of turbulence and can easily be estimated in planets from any instantaneous potential vorticity profile. Our findings lead to the first estimate of Saturn’s energetic power, showing that Saturn’s atmosphere is four times less energetic than the one of Jupiter, consistently with their respective distance to the sun.
Genetic Characterization of timeless Splicing Isoforms and Their Role on the Circadian System in Drosophila
Creators: name: Chacon, Madison
Publisher: name: Brandeis University
Year: 2023
Subjects: Circadian rhythm
temperature adaptation
thermosensitive splicing

description: Circadian rhythms help organisms adapt to their environment by predicting daily changes and are generated by the cyclic transcription, translation and degradation of core clock genes, including timeless. Circadian rhythms have been shown to be both responsive and compensatory to changes in environmental stimuli, such as temperature.Recently, our lab discovered that timeless contains four thermosensitive isoforms, which were linked to temperature adaptation.However, these isoforms have yet to be characterized. Here, we genetically characterized tim isoforms by creating Drosophila melanogaster with shRNAs directed to knockdown all, multiple or individual isoforms. We then determined the locomotor activity of these flies in 12:12 light:dark and inconstant darkness at three different temperatures to see the effect of the isoforms on temperature adaptation, rhythmicity and period.
Exploration of lentiviral vectors and TAT-fusion proteins for the delivery of XIAP protein to neonatal retinal progenitor cells
Creators: name: Szymanska, Irena
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Biology, Cell.
subject: Biology, Animal Physiology.
subject: Chemistry, Biochemistry.

description: Post-transplant apoptosis is a major obstacle to successful cell replacement therapy for retinitis pigmentosa. Over-expression of the X-linked inhibitor of apoptosis (XIAP) protein could increase transplant survival leaving a greater numbers of cells available to replenish photoreceptors lost during retinal degeneration. Sonic Hedge hog expanded C57BL/6 mouse neonatal retinal progenitor cells (Hh-RPCs) were infected with two lentiviral constructs, encoding XIAP/GFP or GFP only, as well as with the TAT-fusion protein, TAT-eGFP. The optimal delivery conditions and expression patterns were assessed. It was found that lentiviral infection, in conjunction with fluorescence activated cell sorting (FACS) allowed for the creation of a nearly pure line of Hh-RPCs which over-expressed XIAP protein for at least one month. Although the TAT-fusion protein efficiently transduced Hh-RPCs, its nuclear localization made it unsuitable for XIAP protein delivery. These results demonstrated two methods of transducing primary retinal progenitor cells and represent an important first step towards efficient cell replacement therapy in the retina.
The Rise of the State, The Demise of The Nation
Creators: name: Clark, John
Publisher: name: Brandeis University
Year: 2010
Subjects: Irish Economy
Irish Nationalism
Irish Politics
Ireland

description: Although proven, socio-demographic shifts do occur as a result of globalization and its economic, political and social externalities, nationalism in Ireland continues to honor its roots in sovereignty and independence and is ingrained in the fabric of society almost two generations into its post-colonial identity. Eurobarometer indicators, Irish survey data personally collected, and an analysis of the recent Irish rejection of the Lisbon Treaty demonstrate that the Irish people remain true to the mission of their forefathers, placing nationalist pride in their sovereignty, culture and religion, combating globalization’s push for further economic integration and the call for a more regionalized Irish identity. Despite absorbing the world’s most rapid, dramatic globalization process, the Irish people have spoken and show a continuation of traditional nationalism based on principles developed over a century ago. The question here addresses whether globalization transcends nationalistic roots or exacerbates them in the case of Ireland.
title: Roman denarii from north-western Hispania, findings from Castromaior (Lugo) : A contextual, numismatic and analytic approach
Creators: name: Orejas Saco Del Valle, Almudena
name: Montero Ruiz, Ignacio
Publisher: name: Deutsches Archäologisches Institut
Year: 2015
Subjects: Castromaior
castro (Portomarín, Lugo)
Denarius
Aes
Pb Isotope
XRF Analyse
Hügelfestung (castro)
antike Minen
Nordwest-Spanien
Pb isotopes
XRF analysis
hillfort (castro)
ancient min­ing areas
North-western Spain

description: Madrider Mitteilungen, 56 (2015)
description: Im Jahr 2009 wurden im Rahmen einer systematischen archäologischen Ausgrabung Castromaiors (Portomarín, Lugo, Spanien) elf römische Denarii gefunden, die zwischen 106 v. Chr. und der augusteischen Zeit datieren. Das Haus 3, in dem die Münzen aufgefunden w
description: In 2009, in the frame of the systematic archaeological excavations carried out in Castromaior (Portomarín, Lugo, Spain), an ensemble of eleven Roman denarii, dated between 106 BC and the Augustan period, was found. The house 3, where the coins were locate
description: En 2009, en el curso de las excavaciones arqueológicas desarrolladas en Castromaior (Portomarín, Lugo, España), se encontró un conjunto de once denarios, datados entre el 106 a. C. y el periodo augusteo. La casa 3, donde fueron halladas las monedas, ilust
A multi-objective approach for RMT design
Creators: name: Liu, Wei
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Engineering, Mechanical.

description: A reconfigurable manufacturing system (RMS) is designed for rapid adjustment of manufacturing capacity and functionality in response to market changes. An RMS consists of a number of reconfigurable machine tools (RMTs) which can process different jobs by quickly changing processing modules. The potential benefits of an RMS may not be achieved if an RMS is not properly designed. Most of the related studies focus on a few individual technical issues, in particular on modularity or configurability of individual RMTs. Other important concerns such as cost and processing accuracy have not been adequately addressed. As a result, many highly reconfigurable manufacturing systems turn out to be unprofitable. For the above reason, this study focuses on optimization of RMT design, including the design of modules and module warehouse, with consideration of three factors: configurability, cost and accuracy. (Abstract shortened by UMI.)
Neural Response to Self-Control Exertion in Competitive Personality Traits
Creators: name: Webster, Elisabeth Ann
Publisher: name: Brandeis University
Year: 2015
Subjects: Electroencephalography (EEG)
ERP
ERN
self-control
competitive personality traits

description: Self-control is an individual’s ability to direct attention and action towards a specific goal while inhibiting other actions or impulses (Baumeister et al., 2007). Through the use of EEG the question of whether self-control is promoted by a more competitive personality can be addressed. In previous research the event related potential called the error related negativity (ERN) has been shown to appear in a greater magnitude in individuals performing a task that requires cognitive control, like a self-control task, when they make a mistake (Hajack et al. 2005). This is thought to occur because the amplitude of the ERN is associated with an individual’s response conflict when an error has been made. This study uses the ERN as a physiological indicator of task engagement and motivation, to investigate how neural responses to self-control failure can be mediated by competitive personality traits. Through the use of the Go/No-Go self-control task, both individually and jointly, it is possible to measure the ERN in response to self-control exertion. The task was explained to the participants as a game with three rounds and the option to earn points to win. This study originally hypothesized that a more competitive person would express a stronger ERN while performing a self-control task because of their drive to succeed over the other participant. In addition it was hypothesized that competitiveness would enhance \r accuracy of task performance due to an increased motivation and focus. However, we found that competitive individuals gain no advantage of performance on the task.
Lipid acquisition by apolipoprotein A-I in ER and Golgi compartments of primary mouse hepatocytes
Creators: name: Maric, Jovana
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Biology, Animal Physiology.
subject: Chemistry, Biochemistry.

description: It was previously unknown what the significance and location of intracellular lipidation of newly synthesized apoA-I in hepatocytes were in plasma HDL formation. By labeling primary mouse hepatocytes with 3H-choline, we showed that phospholipidation of apoA-I is most significant in endoplasmic reticulum (ER) and medial Golgi compartments with minor lipidation upon export from the cell. Intracellular LDL-cholesterol lipidation of apoA-I is absent, with rapid cholesterol accumulation at the plasma membrane. De novo synthesized cholesterol was able to lipidate apoA-I intracellularly to a small but significant level. In hepatocytes lacking ABCA1, phospholipidation and lipidation by de novo cholesterol were both reduced in Golgi, while ER lipidation remained mostly unchanged. Plasma membrane lipidation by LDL-cholesterol was also significantly reduced. This implies that HDL formation begins with apoA-I phospholipidation in the ER, followed by modest cholesterol lipidation in the Golgi, dependent on ABCA1, with the bulk of cholesterol lipidation occurring at the plasma membrane.
Metal concentrations in benthic invertebrates in peatlands.
Creators: name: Chouinard, Julie.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1993
Subjects: subject: Environmental Sciences.

description: In order to assess the influence of various abiotic and biotic factors on metal accumulation in peatlands, insects were collected from bogs, mineral poor fens and circumneutral fens located in Central Ontario. The peatlands represented a gradient in alkalinity from 0 (acid bogs) to 200 $\mu$eq$\cdot$L$\sp{-1}$ (circumneutral fens). Further, the peatlands had important hydrological differences with no obvious inflows in the bogs and inflow/outflow streams in the fens. Given these contrasting environments, it was hypothesized that there would also be differences in metal accumulation in the associated biota. The results of this study indicate that the acidification of peatlands, whether natural or anthropogenic, will not lead to greater availability of metals such as Zn, Cu, Al, and Mn. High organic matter levels may serve to mitigate the effects of acidification on metal availability in such peatlands. (Abstract shortened by UMI.)
The Classical Roots of Enlightenment Social Contract Theory
Creators: name: Callif, William
Publisher: name: Brandeis University
Year: 2018
Subjects: subject: Classics
subject: Enlightenment
subject: Social Contract Theory
subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: Political Theory

description: The purpose of this work is to investigate the classical roots of Enlightenment Social Contract Theory. It is not an analysis of Enlightenment philosophy, but rather an attempt to reconstruct the intellectual framework that served as the foundation upon which the Enlightenment thinkers developed their own theories of the social contract. In order to do this, I had to answer two main questions: (1) can an idea exist in practice before it exists as a neatly defined semantic unit; and (2) how can I test such a proposition. I looked for evidence of theories of the social contract developing alongside φύσις and νόμος, two terms I argue merge over time to form a raw concept of Natural Law. I argue evidence of such a dual movement is the backbone of Enlightenment Social Contract Theory. To find such evidence I turned to the Presocratics for evidence of a semantic merger between φύσις and νόμος, the Sophists for a description of the first theory of the social contract built upon these Presocratic notions of φύσις and νόμος, and Plato for a critique of Sophistic Social Contract Theory. Through this process I was able to find strong evidence for such a thing as classical Social Contract Theory. Furthermore, I was able to answer definitively that a raw form of a concept can indeed exist before it has developed into its own semantic unit.
VHDL implementation of turbo codec
Creators: name: Tong, Yanhui
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Engineering, Electronics and Electrical.
subject: Computer Science.

description: Turbo coding is one of the most significant achievements in coding theory during the last decade. It has been shown in the literature that transmission systems employing turbo codes could achieve a performance close to the Shannon limit. Turbo decoding is the major contributor to the overall complexity of turbo coding. Therefore, the challenge is to implement turbo coding in various communications systems at affordable decoding complexity using current VLSI technology. Four different turbo decoding algorithms were investigated in this thesis. Comparisons on both their performances and implementation complexities were performed. Log-MAP based turbo decoding offers the best compromise among the different turbo decoding algorithms. A Register-Transfer-Level (RTL) fixed-point turbo decoder model based on Log-MAP algorithm was designed and simulated using VHDL as the hardware description language. The RTL model was verified by comparing its simulation results with those obtained from a behavioral model of the same turbo decoder written in C language.
Single and double embryo transfer provide similar live birth rates in frozen cycles
Creators: name: A. Racca
name: P. Drakopoulos
name: L. Van Landuyt
name: C. Willem
name: S. Santos-Ribeiro
name: H. Tournaye
name: C. Blockeel
name: N. P. Polyzos
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Science Policy

description: Research question: Do live birth rates (LBRs) differ in frozen cycles of women who received single versus double embryo transfer? Design: Retrospective cohort study including women who underwent their first frozen embryo transfer (FET) in a tertiary referral University Hospital between 2009–2014. Results: 3601 patients were included in the analysis with 1936 (53.8%) having a single embryo transfer (SET) and 1665 (46.2%) having a double embryo transfer (DET). Overall, 657/3601 (18.24%) had a live birth. LBR were similar between SET and DET either for cleavage [100/757 (13.1%) versus 153/1032 (14.8%), p = .33] or blastocyst stage FET [256/1179 (21.7%) versus 148/633 (23.4%), p = .4). Ongoing pregnancy rates were comparable between DET and SET [316/1665 (18.9%) versus 359/1936 (18.5%)]. Multiple delivery rates were significantly higher in women with DET compared to SET [53/316 (16.7%) versus 7/359 (1.9%), p Conclusions: This is the largest study providing evidence that both SET and DET may result in similar LBR, albeit multiple pregnancy rates are significantly lower in case of SET. Therefore, SET should be the main strategy in women undergoing FET.
MPEC 2024-G202 : 2023 OU4
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Edward R. Hoehl to John E. Whelan, August 2, 1955
Creators: name: Hoehl, Edward R.
Publisher: name: Unknown
Year: 1955
Subjects: Stony Brook
Electricity
Correspondence
Paying bills

description: This letter is written by Edward R. Hoehl to John Whelan on August 2, 1995, in regards to making a payment to Dogwood Hollow's share of the electric bill, contributed to from July 7 to August 1, 1955.
Antifungal activity of compounds isolated from Aspergillus niger and their molecular docking studies with tomatinase
Creators: name: Zulqarnain
name: Iqbal, Zafar
name: Cox, Russell
name: Anwar, Jawad
name: Ahmad, Nasir
name: Khan, Khalid
name: Mudassar Iqbal
name: Nazish Manzoor
name: Khattak, Saeed Ullah
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Cancer

description: Using a dual culture antagonism assay, Aspergillus niger exhibited 51.5 ± 1.1% growth inhibition against Fusarium oxysporum f.sp. lycopersici, the wilt pathogen of tomato. For enhanced production of antifungal metabolites, nutrient optimization was performed and in vitro well-diffusion antifungal assays demonstrated that crude extract obtained from GPYB culture showed a maximum zone of inhibition (8.8 ± 0.4 mm) against the wilt pathogen, which is corroborated by the comparative LCMS profiles of the extracts from all three media i.e. GPYB, YEB and PDB. Two known compounds, Asperazine (m/z 665 [M + H]+) and Nigerone (m/z 571 [M + H]+), were isolated from A. niger and their antifungal activity is reported here for the first time. In MIC experiments, Asperazine and Nigerone inhibited the pathogen at 60 and 80 µg·mL−1 respectively. Molecular docking studies of Nigerone and Asperazine with F. oxysporum tomatinase showed five and six binding interactions respectively.
Designing architecture of a rule-based system for managing phone call interruptions
Creators: name: Sarker, Iqbal H.
name: Kabir, Muhammad Ashad
name: Colman, Alan
name: Han, Jun
Publisher: name: Swinburne
Year: 2024

description: Now-a-days, mobile phones are considered to be "always on, always connected" but mobile phone users are not always attentive and responsive to incoming phone calls. Incoming call notifications such as ringing at an inopportune moment (e.g., meeting) can cause interruptions for both the users and the surrounding people. In this paper, we present a system architecture for managing call interruptions according to individual's call response behavioral rules.
Picture Groups and Simple Minded Collections
Creators: name: Hanson, Eric J.
Publisher: name: Brandeis University
Year: 2021
Subjects: gentle algebras
Nakayama algebras
preprojective algebras
representations of quivers
tau-tilting
torsion classes

description: The goal of this dissertation is to extend the theory of picture groups and picture spaces (as developed in works of Igusa, Todorov, and Weyman) to the class of τ-tilting finite alge- bras. In particular, we aim to generalize the result that the picture space has the structure of a K(π,1) (or Eilenberg MacLane space) for the picture group. In Chapter 1, we further explain this motivation, discuss the fundamentals of representation theory, and introduce the theory on which this thesis lies (namely τ-tilting theory). In Chapter 2, we extend the definitions of the picture group and picture space to our class of interest. We also show that the picture space is a K(π, 1) for the picture group when the algebra’s 2-simple minded collections are characterized by pairwise conditions. In Chapter 3, we show that there exist τ-tilting finite algebras whose 2-simple minded collections are not characterized by pair- wise conditions. In doing so, we develop internal criteria for determining when a set of “bricks” is contained in a 2-simple minded collection and use this criteria to study gentle algebras and preprojective algebras in detail. In Chapter 4, we prove the 2-simple minded collections of Nakayama algebras and Nakayama-like algebras are characterized by pairwise conditions, providing new examples of algebras whose picture spaces are K(π,1)’s for their picture groups.
Geographies of Schooling: An Introduction
Creators: name: Kramer, Caroline
name: Jahnke, Holger
Publisher: name: Springer International Publishing
Year: 2019

description: The chapter offers a first introduction to the field of geographies of schooling in the light of current literature from geography and neighboring disciplines. Several dimensions within the complex interrelation between education and space are scrutinized from different disciplinary perspectives. With a clear focus on spatiality and the territoriality of schooling and education this chapter offers an overview over the broad thematic, methodological and disciplinary approaches that have been undertaken in the diverse research projects present in this volume. The authors conclude with a brief outlook on future research in this emerging field.
Market Research Without a Market: Consumers, the State, and the Economy of Waste in the Soviet Union, 1947–1991
Creators: name: Laas, Nataliia
Publisher: name: Brandeis University
Year: 2027
Subjects: Consumer Behavior
European History
Former Soviet Union
Market Research
Political Economy
Women's Studies

description: The dissertation explores the history of market research and consumer studies in the Soviet Union from the end of the Second World War to the country’s collapse in 1991. Drawing on previously unexplored files from thirteen archives in Estonia, Russia, Ukraine, and the U.S., the study provides the first comprehensive account of this new field within the socialist social sciences. The dissertation demonstrates that the Soviet state’s knowledge of consumers developed as a collaborative project between retailers, economists, statisticians, sociologists, and market researchers, as well as civic-minded consumers, particularly women. Far from being ignorant or indifferent to consumers’ personal needs, the Soviet state, however, cultivated market research and consumer studies as a response to the pressing problem of waste, excess, and overproduction in the consumer sector of the Soviet economy (or the economy of waste, as it is termed in the dissertation). These findings fundamentally revise the existing historiography, which overlooks economic excess and conceptualizes the socialist economy primarily as an economy of shortages. The dissertation thus sheds new light on the relations between the Soviet state and its citizens, on knowledge production under socialism, and on the ways the socialist economy operated.
Genetic Counselor Perceptions of Usability and Implementation of Genetic Carrier Screening Result Disclosure Through a Virtual Assistant
Creators: name: Davila, Silvana Patricia
Publisher: name: Brandeis University
Year: 2023
Subjects: Carrier Screening
Genetic Counseling
Prenatal genetics
Result Disclosure
Virtual Assistant

description: The increased demand for genetic testing and genetic expertise has shed light on the increased workload that the genetic counselor (GC) workforce is currently facing. While some studies have attempted to explore triaging models and a variety of service delivery models to address this increased workload, solutions are still needed to provide patients with quality routine services that GCs may not be able to continue to provide. The aim of this study was to explore the perceptions of prenatal GCs on the use of a virtual assistant (V.A.) to provide carrier screening result disclosure. This study was conducted through an online survey asking participants about their views of a demonstrated V.A., their current practices, comfort with their patients receiving results through a V.A., comfort implementing a V.A., and their current workload. Recruitment took place via the National Society of Genetic Counselors’ listserv, social media posts, and snowball sampling, resulting in a total of 14 prenatal GCs participating in this study. The analysis of results showed that most participants felt a V.A. provided a carrier screen result disclosure in a similar manner to how they would conduct this type of session (85.7%, n=12/14), however, they were only comfortable with a V.A. disclosing low risk results. Responses regarding current practices showed that GCs are handling the majority of the workload surrounding carrier screening, and while GCs expressed that a V.A. used in this setting would assist with their workload, they were uncomfortable with potential implementation of a V.A. Our results show that while GCs see the value of using a V.A. for routine tasks such as low risk carrier screen result disclosure, other clinical questions exist. These include further exploration to determine the appropriate amount of clinical information provided by a V.A. as well as the use of a V.A. for high-risk results, such as positive results for X-linked conditions.
Applications of a hydroxy-directed Diels-Alder reaction and further investigation of the tandem oxy-CopeEne, and oxy-CopeEneClaisen reactions
Creators: name: MacLean, Peter Ross
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Chemistry, Organic.

description: The recent development of a hydroxy-directed Diels-Alder reaction, which enables control of both regio- and diastereoselectivity, has prompted an investigation of potential applications. Extending the methodology to more complicated dienes, such as those created via the tandem oxy-Cope/Ene reaction, offers the potential for rapid construction of polycyclic molecules with significant stereochemical complexity.* The simplicity and efficiency of this technique has also inspired its employment as the primary disconnection in the production of a library of analogues of the unsaturated dialdehyde Isovelleral.* Also examined herein is the recently discovered tandem oxy-Cope/Ene/Claisen reaction; a highly diastereoselective method for generating trans -decalin systems containing quaternary carbon centers. Showing potential as a tool in diterpene synthesis, the scope and limitations of this reaction were further investigated by attempting the synthesis of a rosane derivative 97, recently isolated from the liverwort Gackstroemia decipiens .* *Please refer to dissertation for diagrams.
Effectiveness of the Kinetic Wedge foot orthosis modification to improve gait posture
Creators: name: Rambarran, Kerry K
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Health Sciences, Rehabilitation and Therapy.

description: Clinically, Functional Hallux Limitus (FHL) has been identified as a contributor to the disruption of proper progression of the inverted pendulum through the sagittal plane. The Kinetic Wedge Custom Foot Orthotic (CFO) modification has been used by the podiatric community to facilitate proper first metatarsal-phalangeal (MTP) joint function and improve gait posture. The aim of this study was to determine the effectiveness of the Kinetic Wedge custom foot orthosis (CFO) modification to improve gait, posture, centre of pressure velocity, plantar pressures of the foot, and perceived pain. Fifteen healthy subjects (9 women, 6 men) 22 to 53 years of age diagnosed with moderate to severe FHL volunteered for the study. Kinematic and plantar pressure data were collected without Kinetic Wedge (NKW) and with Kinetic Wedge(KW). There was a significant reduction of plantar pressure under the first MTP, however, there were no significant changes in plantar pressures under the hallux and fifth metatarsal. There was no significant difference in centre of pressure velocities. In addition, there were no significant increases in trunk, hip, knee, and ankle range of motion. Furthermore, self perceived pain did not significantly reduce 2 months after testing.
Differential Responses to Neuromodulation in Model Neurons of the Crustacean Stomatogastric Ganglion
Creators: name: Hoyland, Alec
Publisher: name: Brandeis University
Year: 2018
Subjects: computational
stg
Neuroscience

description: Neuronal networks must produce stable circuit output for sustained periods of time\r despite environmental perturbation. In addition, they must be sensitive to key\r endogenous signaling to produce differing output. The STG manages these\r competing objectives while remaining degenerate to ion channel density.\r Neuromodulators can produce a diverse set of network states using the same cellular\r and synaptic morphology. In particular to the STG, the dense, tangled neuropil and\r gradations in reversal potential render neurons isopotential with respect to the\r somata. Neuromodulators, then, play the role of maintaining and switching network\r activity. For stable and responsive biological activity, degenerate networks must still\r be robust to environmental perturbation and responsive to intentional modulation.\r In this thesis, I describe red pigment-concentrating hormone (RPCH) acting as a\r neuromodulator on a computational model of a rhythmic motor circuit.
Multiple Storage Configuration For InvenioRDM at New York University
Creators: name: Pechekhonova, Kate
name: Verhoff, Deb
Publisher: name: Zenodo
Year: 2024
Subjects: InvenioRDM
Institutional Repositories
Storage
Preservation
User Experience
OR2024

description: Customizations made by NYU Libraries for their InvenioRDM instance, including multiple file storage options and changes to the user interface.
Antimicrobial secondary metabolites of an endolichenic Aspergillus niger isolated from lichen thallus of Parmotrema ravum
Creators: name: Srichandan Padhi
name: Masi, Marco
name: Sujogya K. Panda
name: Luyten, Walter
name: Cimmino, Alessio
name: Kumanand Tayung
name: Evidente, Antonio
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology

description: A new 6-benzyl-γ-pyrone (1), named aspergyllone was isolated from the culture filtrates of an endolichenic fungus Aspergillus niger Tiegh, obtained from lichen thallus Parmotrema ravum (Krog & Swinscow) Serus, collected in India. 1 was isolated for the first time from an endolichenic fungus together with six other known metabolites identified as aurasperones A (2) and D (3), asperpyrone A (4), fonsecinone A (5), carbonarone A (6) and pyrophen (7). The compounds were tested against a panel of human, plant, food borne and fish pathogens. Aspergyllone showed strong selective antifungal activity against Candida parapsilosis (Ashford) Langeron & Talice, with an IC50 of 52 µg/mL. Aurasperone A and pyrophen showed moderate to strong antimicrobial activity inhibiting seven different test pathogens, being pyrophen active with IC50 ranging from 35 to 97 µg/mL.
Phytochemicals, antioxidant, anti-acetyl-cholinesterase, and antimicrobial activities of decoction and infusion of Pelargonium graveolens
Creators: name: Ennaifer, Malek
name: Taroub Bouzaiene
name: Messaoud, Chokri
name: Moktar Hamdi
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: In Tunisia, Pelargonium graveolens is widely consumed as a food aromatizing hydrosol. Recent studies have shown the potential of plant solvent-free extracts as food and pharmaceutical natural additives. Accordingly, in this study, we investigate the phenolic content, the volatile fractions of green P. graveolens extracts such as infusion and decoction, and we evaluate their biological activities. The total phenolic content of the infusion (27.05 mg GAE/gDM) is significantly different from that of decoction (31.2 mg GAE/gDM). The GC-MS analysis identified about twenty volatile components in both extracts. The DPPH inhibition and the β-carotene bleaching tests of the infusion and the decoction had considerable results. Besides, infusion and decoction exhibited a relatively high anti-acetyl-cholinesterase activity and a considerable antimicrobial activity against S. aureus, among three tested pathogenic bacteria.
Neural network based feedback linearization control of an unmanned aerial vehicle
Creators: name: Jiang, Yiwu
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Engineering, Mechanical.

description: In this thesis, a flight control design of an unmanned aerial vehicle (UAV) using neural network based feedback linearization and the output redefinition technique is presented. The UAV model we chose in this research is a nonlinear nonminimum phase system. The output redefinition technique is used in a way such that the resulting system is minimum phase and can be inverted. The nonlinear autoregressive moving average (NARMA-L2) neural network is trained off-line to identify the forward dynamics of the UAV model with the redefined output, and then inverted to force the real output to approximately track the desired trajectory. The results shows that a good tracking performance can be achieved using this control scheme.
Ectopic gene conversions in eukaryotic genomes
Creators: name: Benovoy, David
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Biology, Genetics.

description: We studied ectopic gene conversions, i.e., gene conversions between duplicated genes located at different chromosomal positions, in eukaryotic genomes. In the first part we examined the factors affecting ectopic gene conversions in the human genome and compared their characteristics to those observed in other eukaryotic and prokaryotic species. In the second part, we examined the effect that ectopic conversions have on the GC-content of the duplicated genes found in yeast and Arabidopsis genomes. Using Stanley Sawyer's method implemented in his GENCONV program, we identified and characterized the ectopic gene conversions of the human genome. The human gene families containing 3 or more members contained 483 pairs of converted genes. The average length of conversions is 371+/-752 (+/- standard deviation) nucleotides long with the smallest conversions being 10 nucleotides long and the largest 6011 nucleotides long. Larger gene conversions are found between sequences that are more similar and the frequency of intra-chromosomal gene conversion increases as the distance between genes decreases. Pairs of intra-chromosomal genes sharing the same transcriptional orientation convert more often than intra-chromosomal genes in opposite transcriptional orientation. The excess of conversions in the 3'-end suggest incomplete cDNA molecules are often involved in gene conversions with chromosomal gene copies. Allelic recombination has previously been shown to increase the GC-content of the sequences of a wide variety of eukaryotic species. Ectopic recombination between clustered tandemly repeated genes has also been shown to increase their GC-content. Here we show that gene conversions between the dispersed genes found in the duplicated regions of the yeast and Arabidopsis genomes also increases their GC-content when these genes are more than 88% similar.
Time dependent complex scaling: Quantum dynamics in strongly perturbed systems
Creators: name: Van Vlack, Cole
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Physics, Elementary Particles and High Energy.

description: We have begun development of a tool for investigating the bound state dynamics of single electron systems in intense fields. This was done by implementing the method of uniform complex scaling in a 1D test system in two different ways and have shown that the use of the "c-norm" in non-Hermitian quantum mechanics can fail for time dependent simulations. We have developed the method of complex backscaling which transforms the wavefunction from the complex scaled space back into real space and have shown that it is more robust than the "c-norm" and predicts the correct ionization when compared to simulations done in real space. We have also begun using the complex scaling method in a 2D NZ model but it seems that the nature of the potential requires a more difficult type of scaling which causes problems within the calculations.
Composition and antioxidant activity of the essential oil of Artemisia annua L
Creators: name: Zhigzhitzhapova, Svetlana V.
name: Dylenova, Elena P.
name: Gulyaev, Sergey M.
name: Tuyana E. Randalova
name: Taraskin, Vasiliy V.
name: Zhargal A. Tykheev
name: Radnaeva, Larisa D.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified

description: Artemisia annua L. is an annual Eurasian desert-steppe plant. The composition of essential oils found in Artemisia annua from Russian (Buryatian) flora was analyzed in this work using gas chromatography mass-spectrometry method. Artemisia ketone, β-selinene, caryophyllene, caryophyllene oxide, germacrene D were the main components of the analyzed essential oils. The comparison of own and literature data showed that the essential oils of A. annua conditionally could be divided into “Asian” and “European” groups. Our samples, referring to “Asian” profile, exhibited higher antiradical activity in comparison with data from previously published studies.
title: Should All Patients With Breast Cancer be Offered Genetic Testing?
title: Reactions to the ASBrS Consensus on Genetic Testing for Hereditary Breast Cancer
titleType: Subtitle
Creators: name: Tripi, Kelly
Publisher: name: Brandeis University
Year: 2020
Subjects: Genetic counseling
Genetic testing
Cancer Genetics
Breast Cancer

description: The increase in genetic testing availability, coupled with the increase in demand for genetic counselors has led some groups to evaluate who is offered genetic testing and genetic counseling, and how those services are provided. Hereditary breast cancer risk assessment is one of the fields currently undergoing re-evaluation of services. In February of 2019, the American Society of Breast Surgeons (ASBrS) released a consensus statement calling for all breast cancer patients to be offered genetic testing, which is a departure from the widely accepted National Comprehensive Cancer Network (NCCN) guidelines that recommend genetic testing based on a combination of certain cancer diagnoses, age of cancer diagnosis, as well as family history. It is the aim of this study to understand the impact of the ASBrS guidelines on the very group who stands to be most impacted by them:
description: genetic counselors.
description: A survey of 73 current cancer genetic counselors in the United States sought to understand the clinical practice of genetic counselors both before and after the announcement of the ASBrS guidelines. Additionally, we sought to understand both the personal and professional opinions of genetic counselors in regard to the ASBrS guidelines. Overall, participants were neutral on whether they personally supported testing all breast cancer patients, however those who were not part of a NCCN institution were more likely to personally support testing than those who were part of a NCCN institution (p = .001, !2 = 18.2). Additionally, participants who were not part of a NCCN institution were more likely to believe the ASBrS guidelines have clinical utility compared to participants who were part of a NCCN institution (p = .003, !2 = 16.3).
description: Over 70% of participants stated they were concerned about following the ASBrS guidelines due to billing and/or insurance coverage as well as the burden on genetic counselors. At least 50% of participants stated they would be comfortable if a non-genetics provider performed pre-test counseling, risk assessment or ordered a breast STAT panel. Thematic analysis of open-ended responses revealed 20.8% and 29.2% of participants were actively considering insurance and testing criteria, respectively, and 33.3% of respondents were considering alternative delivery methods in response to the ASBrS guidelines and an increase in referrals.
description: As genetic testing availability continues to increase, there is a need for concordance among both genetics and non-genetics providers on how to best provide testing, and for whom it should be offered. The views of the genetic counselors who participated in this study emphasized the need for further discussion and examination of the impacts of the ASBrS guidelines on the hereditary breast cancer field.
Exploring the technical qualities of the self-assessment process in the intermediate grades.
Creators: name: McLeod, Leslie.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Education, Curriculum and Instruction.

description: The focus of this study is to explore the implementation of a proposed self-assessment framework in grades 6, 7 and 8. Educational assessment literature proposes a number of advantages regarding the use of self-assessment. Assessment experts recommend that it provides an excellent way of familiarizing the students with the proposed learning standards as both students and teacher must have similar understandings of the assessment criteria. Others suggest that students are also able to participate more responsibly and enthusiastically in the learning process if they have a deeper understanding of the learning goals and related standards for performance. Although self-assessment is recommended with enthusiasm in the professional teaching literature, there is little scientific research that supports its use as an assessment process in the elementary grades. The present study is exploratory in nature and examines the self-assessment process by investigating the implementation of a researcher-proposed framework for student self-assessment. Six teachers participated in this study and worked with their students to develop rubrics that were used for student self-assessment in paragraph writing. The framework included implementational steps as well as checks to ensure the validity and reliability of the process. The self-assessment process undergone by these six classes is documented and the assessment results are analyzed to determine levels of validity and reliability. In addition, the researcher has identified important factors which can impact the validity and reliability of the results. (Abstract shortened by UMI.)
Silymarin, a polyphenolic flavonoid impede Plasmodium falciparum growth through interaction with heme
Creators: name: Mina, Pooja Rani
name: Kumar, Yogesh
name: Ajeet Kumar Verma
name: Feroz Khan
name: Sudeep Tandon
name: Anirban Pal
name: Darokar, Mahendra Pandurang
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified

description: A polyphenolic flavonoid, Silymarin isolated from Silybum marianum is widely known for its hepatoprotective action. In the present study anti-plasmodial activity of Silymarin has been demonstrated for the first time having IC50 of 14 ± 0.33 μM against the NF-54 strain of P. falciparum with high selectivity index (>100). The parasitostatic action is exerted through inhibition of β-hematin/hemozoin formation which is due to the interaction (Kd = 3.63 ± 0.9µM) of silymarin with free heme in a Stoichiometry of 1:1 Silymarin: heme complex resulting into heme-induced membrane damage in the parasite. Silymarin could hinder the glutathione and hydrogen peroxide-induced heme detoxification. Silymarin also induces apoptosis in the parasite through the elevation of caspase-3 level in a dose-dependent manner. Results from the docking studies suggest that Silymarin interacts with heme.