cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Preparation, Characterization and in vitro Anticoagulant Activity of Corn Stover Xylan Sulfates
Creators: name: Cheng, He-Li
name: Liu, Hao
name: Feng, Qing-Hua
name: Xie, Yi-Min
name: Zhan, Huai-Yu
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Hematology
subject: Plant Biology

description: A new anticoagulant agent was prepared by introducing sulfate groups into corn stover xylan through homogeneous reactions. Three organic solvents, N, N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO) and formamide (FA), were adopted as reaction media, with the assistance of LiCl. Structural characterization by FT-IR and 13CNMR showed that xylan sulfate (XS) could be successfully synthesized with SO3∙Pyridine (SO3∙Py) complexes sulfation reagent in the three media. The effect of sulfation temperature, sulfation time, media type and molar ratio of -SO3/-OH on the degree of substitution (DS) and degree of the polymerization (DP) were studied. DMF/LiCl were more effective than DMSO/LiCl and FA/LiCl in preparation of xylan sulfate with high DS. The optimal conditions for sulfation were obtained when SO3∙Py complex was added to DMF/LiCl with -SO3/-OH ratio of 1.5:1 and maintained at 50 °C for 3 h. Degree of polymerization of xylan was decreased during the sulfation process and DMF/LiCl offered the least xylan degradation as compared with DMSO/LiCl or FA/LiCl. Anticoagulant activities of the resultant xylan sulfates with different DS were evaluated by using activated partial thromboplastin time (APTT), thrombin time (TT), and prothrombin time (PT). Results indicated that the introducing of sulfate groups into xylan did endow the polysaccharides with anticoagulant activity. The APTT and TT of XS with DS of 1.20 reached 141 s and 45.3 s at a dosage of 20 μg/mL, while the APTT and TT values for the blank sample were only 35.5 s and 15.6 s. Furthermore, coagulation time was prolonged with the increase of DS and the concentration of XS. Our findings provide new insights into the value-added utilization of agricultural biomass.
Seco-pregnane glycosides from the stems of Epigynum auritum
Creators: name: Gao, Fei
name: Yao, Yuan-Cheng
name: Wan, Zong
name: Cai, Sheng-Bao
name: Fan, Jian
name: Zhao, Tian-Rui
name: Cao, Jian-Xin
name: Cheng, Gui-Guang
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Chemical investigation of the stems of Epigynum auritum led to the isolation and identification of a novel 16,17-seco pregnane glycoside, epigynoside D, along with other three known compounds (2–4). The structure of compound 1 was elucidated by means of spectroscopic analysis, including HRESIMS, 1D and 2D NMR experiments. All isolated compounds were tested for their in vitro cytotoxic, immunological and anti-acetylcholinesterase activities.
Investment modeling to optimize the technical and economic indicators of agricultural machinery utilization for the production of farm crops in Iran
Creators: name: Jalalzadeh, Behnam
name: Borghei, Ali Mohammad
name: Almassi, Morteza
Publisher: name: figshare
Year: 2017
Subjects: subject: 140201 Agricultural Economics
subject: FOS: Economics and business

description: Investment modeling to optimize the technical and economic indicators of agricultural machinery utilization for the production of farm crops in Iran
Phytochemical composition and biological activities of Artemisia quettensis Podlech ethanolic extract
Creators: name: Farahani, Zahra Bagheri
name: Mirzaie, Amir
name: Ashrafi, Fatemeh
name: Hesari, Maryam Rahimpour
name: Chitgar, Ali
name: Noorbazargan, Hassan
name: Rahimi, Arian
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Plant Biology

description: The present study aim to investigate the phytochemical composition, antibacterial, antioxidant and anticancer activities of the ethanolic extract from aerial parts of Artemisia quettensis Podlech. The aerial part of A. quettensis Podlech extract was used for Gas chromatography–mass spectrometry (GC-MS) analysis, antioxidant, antibacterial and anticancer activities. GC/MS analysis of extract from this plant showed 23 major components and the most dominant components were acetic acid, [4-(1-hydroxy-1-methylethyl) cyclohex-1-enyl] methyl ester (13.88%), trans-Phytol (10.06%) and 2,6-Dimethyl-2,6-octadiene-1,8-diol diacetate (6.8%). The extract had significant antibacterial and anticancer effects. The highest percentage of antioxidant activity was 78.46% at 2 mg/mL concentration of extract. Moreover, the highest antibacterial effects of extract were against to gram-positive bacteria and the IC50 cell cytotoxicity value on HT29 cell line in 24 h, 48 h and 72 h were 31.54, 6.08 and 2.96 mg/mL, respectively. From this study, A. quettensis Podlech could be considered as a promising source for novel drug compounds.
Three new diterpenoids from Croton laui Merr. et Metc
Creators: name: Yang, Li
name: Wu, Zhong-Nan
name: Zhang, Yu-Bo
name: Chen, Neng-Hua
name: Zhuang, Ling
name: Li, Yao-Lan
name: Wang, Guo-Cai
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Three new diterpenoids, including one labdane diterpenoid (1) and two cembrane diterpenoids (2–3), were isolated from the aerial parts of Croton laui, along with four known analogues (4–7). Their structures were elucidated by spectroscopic analysis and comparison with literature data. All compounds were evaluated for their cytotoxicity against two tumour cell lines.
Application of IATA – A case study in evaluating the global and local performance of a Bayesian network model for skin sensitization
Creators: name: J. M. Fitzpatrick
name: G. Patlewicz
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Genetics
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy

description: The information characterizing key events in an Adverse Outcome Pathway (AOP) can be generated from in silico, in chemico, in vitro and in vivo approaches. Integration of this information and interpretation for decision making are known as integrated approaches to testing and assessment (IATA). One such IATA was published by Jaworska et al., which describes a Bayesian network model known as ITS-2. The current work evaluated the performance of ITS-2 using a stratified cross-validation approach. We also characterized the impact of replacing the most significant component of the network, output from the expert system TIMES-SS, with structural alert information from the OECD Toolbox and Toxtree. Lack of structural alerts or TIMES-SS predictions yielded a sensitization potential prediction of 79%. If the TIMES-SS prediction was replaced by a structural alert indicator, the network predictivity increased up to 87%. The original network’s predictivity was 89%. The local applicability domain of the original ITS-2 network was also evaluated using reaction mechanistic domains to understand what types of chemicals ITS-2 was able to make the best predictions for. We found that the original network was successful at predicting which chemicals would be sensitizers, but not at predicting their potency.
A new diphenyl ether derivative from Mirabilis himalaica
Creators: name: Zhou, Si-Yu
name: Wang, Guo-Wei
name: Zou, Yan-Lin
name: Deng, Li-Qing
name: Liu, Ming-Xu
name: Liao, Zhi-Hua
name: Lan, Xiao-Zhong
name: Chen, Min
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: One new compound, himalain A (1), together with 12 known compounds were isolated from Mirabilis himalaica. Their structures were determined by spectroscopic methods, including 2D NMR techniques, and the absolute configuration of the 1,2-diol moiety in 1 was defined through Riguera’s method. All isolated compounds were tested for their cytotoxic and antibacterial activities.
Additional file 1 of Skin oncoplasties: O-to-Z technique a technique of choice in situation of limited resources? Case of Burkina Faso
Creators: name: Zongo, Nayi
name: Ouedraogo, N. L. Marie
name: Windsouri, Mamadou
name: Yameogo, Laure S. C.
name: Kouchika Chabi, Thierry R.
name: Niamba, Pascal
name: Traore, Adama
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Additional file 1.
Permutation flow-shop scheduling problem to optimize a quadratic objective function
Creators: name: Ren, Tao
name: Zhao, Peng
name: Zhang, Da
name: Liu, Bingqian
name: Yuan, Huawei
name: Bai, Danyu
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: A flow-shop scheduling model enables appropriate sequencing for each job and for processing on a set of machines in compliance with identical processing orders. The objective is to achieve a feasible schedule for optimizing a given criterion. Permutation is a special setting of the model in which the processing order of the jobs on the machines is identical for each subsequent step of processing. This article addresses the permutation flow-shop scheduling problem to minimize the criterion of total weighted quadratic completion time. With a probability hypothesis, the asymptotic optimality of the weighted shortest processing time schedule under a consistency condition (WSPT-CC) is proven for sufficiently large-scale problems. However, the worst case performance ratio of the WSPT-CC schedule is the square of the number of machines in certain situations. A discrete differential evolution algorithm, where a new crossover method with multiple-point insertion is used to improve the final outcome, is presented to obtain high-quality solutions for moderate-scale problems. A sequence-independent lower bound is designed for pruning in a branch-and-bound algorithm for small-scale problems. A set of random experiments demonstrates the performance of the lower bound and the effectiveness of the proposed algorithms.
Isolation of flavonoids from apple peel using novel graphene oxide cotton fiber
Creators: name: Z. Xu
name: R. Peng
name: X. Chen
name: R. Ghosh
name: H. P. V. Rupasinghe
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy
subject: Plant Biology

description: A novel graphene oxide cotton fibre (GOF) was used to adsorb flavonoids from crude ethanol extracts derived from apple peels. Ultra-high pressure liquid chromatography–mass spectrometry was used to analyse polyphenol content, and the resulting data demonstrated that GOF-based flash chromatography can be used to efficiently separate polyphenols from sugars and can facilitate the removal of 95% of the sugar content. Flavonoids can be easily separated from phenolic acids. Chalcones and flavonols were eluted with 100% methanol and subsequently flavan-3-ols can be eluted with 0.04 M sodium hydroxide. The novel GOF has the potential to be used in the isolation of flavonoids.
title: Revista Portuguesa de Investigação Educacional, n. 19 (2019): Educação, inclusão e sucesso para todos
title: Educação, inclusão e sucesso para todos
titleType: AlternativeTitle
Creators: name: Revista Portuguesa De Investigação Educacional
Publisher: name: Revista Portuguesa de Investigação Educacional
Year: 2019

description: Apresentação...11-13 Perceções de professores de 1.º ciclo sobre a implementação de um programa de promoção de mudanças no processo de ensino e aprendizagem. O caso das comunidades escolares de aprendizagem Gulbenkian XXI...14-40 Nos trilhos da flexibilidade curricular. O que vimos, ouvimos e refletimos...41-66 Análise do meio escolar na perspetiva dos agentes educativos: características, dinâmicas e condutas...67-89 PertenSer: avaliação de um projeto comunitário de promoção do sucesso escolar...90-120 A língua gestual e o ensino de surdos: uma reflexão sobre as práticas bilingues...121-140 Inclusão de jovens adultos com dificuldades intelectuais e desenvolvimentais no ensino superior: contributos da literatura no contexto europeu...141-166 Projeto 3I: mediação intercultural, inclusão e educação...167-192 Como se tece a oferta educativa de natureza profissional no território: entre a encenação dos pactos e a imposição burocrática...193-221 MusicalMente. Programa de educação emocional com teatro musical...222-256 Da gestão da sala de aula à aprendizagem: o uso da fenomenografia na análise das conceções de gestão de sala de aula dos formandos...257-280 Formação de professores e utilização das tecnologias digitais na escola...281-307
A new phenolic glycoside from the stem of Dendrobium nobile
Creators: name: Zhou, Xue-Ming
name: Zheng, Cai-Juan
name: Wu, Jia-Ting
name: Chen, Guang-Ying
name: Zhang, Bin
name: Sun, Chong-Ge
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: A new phenolic glycoside dendroside (1), together with seven known compounds (2–8) were isolated from the stems of Dendrobium nobile. The structures of these compounds were elucidated using comprehensive spectroscopic methods. The inhibitory activities of all compounds against three cancer cell lines HeLa, MCF-7 and A549 were evaluated.
A new wortmannine derivative from a Tripterygium wilfordii endophytic fungus Talaromyces wortmannii LGT-4
Creators: name: Sun, Jing-Yun
name: Zhong-Duo Yang
name: Fu, Guang-Chao
name: Wang, Yong-Gang
name: Xue, Hong-Yan
name: Shu, Zong-Mei
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Plant Biology

description: A new wortmannine derivative named wortmannine E (1) was isolated from Talaromyces wortmannii LGT-4, an endophytic fungus of Tripterygium wilfordii. Its structure was established by 1D and 2D NMR spectra.
Synthesis of crystalline Mo–V–W–O complex oxides with orthorhombic and trigonal structures and their application as catalysts
Creators: name: Qiu, Chuntian
name: Chen, Chen
name: Ishikawa, Satoshi
name: Zhang, Zhenxin
name: Murayama, Toru
name: Ueda, Wataru
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Computational Biology

description: Crystalline Mo–V–W–O complex oxides with the orthorhombic or trigonal structure were synthesized by a hydrothermal method. Those Mo–V–W–O samples with various amounts of tungsten were characterized by inductively coupled plasma atomic emission spectroscopy, TEM, STEM–EDX, X-ray diffraction, Rietveld analysis, and a N2 adsorption method. It was found for the first case that an additional metal such as W can be successfully incorporated into the trigonal Mo–V–O structure by using (CH3CH2NH3)2Mo3O10.The alkylammonium cation acted as a structural stabilizer that was requisite for the formation of a trigonal structure when additional metal ions were present. For the orthorhombic Mo–V–W–O structure, introduction of W into the orthorhombic structure caused a rod segregation effect by which nanoscale crystals formed and the external surface area greatly increased. Additionally, these Mo–V–W–O materials were applied as catalysts for the gas phase selective oxidation of acrolein to acrylic acid. The best catalyst was assigned to the orthorhombic Mo–V–O–W7.5, which possessed an ordered arrangement of heptagonal and hexagonal channels and a large external surface area.
EC0096.pdf
Creators: name: Jalalzadeh, Behnam
name: Borghei, Ali Mohammad
name: Almassi, Morteza
Publisher: name: figshare
Year: 2017
Subjects: subject: 140201 Agricultural Economics
subject: FOS: Economics and business

description: Investment modeling to optimize the technical and economic indicators of agricultural machinery utilization for the production of farm crops in Iran
Dilated cerebral venous system observed in growth-restricted fetuses
Creators: name: Baron, Joel
name: Mastrolia, Salvatore Andrea
name: Shelef, Ilan
name: Tirosh, Dan
name: Daniel-Spiegel, Etty
name: Reli Hershkovitz
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Purpose: The dilation of the fetal cerebral veins is a rare phenomenon that may be associated to a bad obstetric outcome, and is usually connected to antenatal thrombosis of the posterior dural venous sinuses. There are several descriptions of cerebral vein distension on magnetic resonance imaging (MRI), but all of them are detected postnatally. We present herein two cases of fetal antenatal cerebral dilation of the venous system, without any association to any sign of vein thrombosis, and a systematic review of literature regarding pathogenesis, diagnosis and outcomes associated to the antenatal detection of this condition with the use of MRI. Materials and methods: To identify potentially eligible studies, we searched PubMed, Scopus, Cochrane Library (all from inception to October 20th, 2016) and applied no language restrictions. Results: The electronic database search provided a total of 22,843 results. After the exclusion of duplicates, manuscripts that resulted not relevant to the review based on title and abstract screening, and analysis of manuscripts eligible for full-text assessment, no papers were found related to the subject reported in the present manuscript. Conclusions: Our report adds importance to MRI as a tool in cases of complex ultrasound finding with the presence of fetal heart failure and deterioration of fetal growth, in order to improve the prognostic evaluation and patient?s counseling.
Additional file 1 of Specialist wait time reporting using family physicians’ electronic medical record data: a mixed method study of feasibility and clinical utility
Creators: name: Naimer, Michelle S.
name: Aliarzadeh, Babak
name: Bell, Chaim M.
name: Ivers, Noah
name: Jaakkimainen, Liisa
name: McIsaac, Warren
name: Meaney, Christopher
name: Moineddin, Rahim
name: Permaul, Joanne A.
name: Makuwaza, Tutsirai
name: Kukan, Sahana
Publisher: name: figshare
Year: 2022
Subjects: subject: Biotechnology
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1.
Régimes de réponse de structures en béton armé impactées par des avalanches de neige
Creators: name: Ousset, I.
name: Bertrand, D.
name: Thibert, E.
name: Limam, A.
name: Naaïm, M.
Publisher: name: Academic Journal of Civil Engineering
Year: 2020

description: Cet article traite du comportement de structures en béton armé (BA) sous l’effet de chargements d’avalanche de neige. L’approche pression-impulsion proposée permet de mettre en exergue trois types de comportement théoriques en fonction de l’impulsion du chargement. En pratique, si l’on confronte les diagrammes obtenus pour deux types de structure à des données réelles de signaux de pression d’avalanche, on s’aperçoit que la structure de protection de type mur en L étudiée ici est susceptible de se comporter de façon quasi-statique alors qu’une structure de type poteaux-poutres aurait tendance à se comporter de façon dynamique.
description: Academic Journal of Civil Engineering, Vol 34 No 1 (2016): Special Issue - RUGC 2016 Liège
EACS 2016 paper - Viability of optical tracking systems for monitoring deformations of a long span bridge
Creators: name: Brownjohn, James
name: Hester, David
name: Xu, Yan
name: Bassitt, J.
name: Koo, K-Y
Publisher: name: The University of Sheffield
Year: 2017
Subjects: classificationCode: 401799
subject: Mechanical engineering not elsewhere classified

description: EACS 2016 Paper No. 172 (113)

Characterisation of both dynamic and quasi-static deformations of suspension bridges is essential to manage their serviceability and to appreciate the internal forces due to the various live loads effects of wind, temperature and traffic. GPS is commonly used for the largest, most flexible structures but the limitations are not well understood and accelerometers cannot capture the extreme low frequency movements. Optical displacement tracking has potential to avoid all these errors but has different types of limitation that need to be evaluated and mitigated. In attempt to cross-validate optical tracking technology against GPS data, a commercial optical system the Imetrum ‘Video Gauge’ was used at Humber Bridge, after first initial experiments on a short span bridge to identify the most effective way to deploy it in the field for measurements at very long range. Some results are presented illustrating the character of the observed deformations and the limitations of the various forms of deformation monitoring instrumentation. In particular limitations of GPS were highlighted through comparison with Video Gauge and accelerometer data.
Heteroskedasticity-robust semi-parametric GMM estimation of a spatial model with space-varying coefficients
Creators: name: Wei, Hongjie
name: Sun, Yan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Plant Biology
subject: FOS: Biological sciences

description: Heteroskedasticity-robust semi-parametric GMM estimation of a spatial model with space-varying coefficients. Spatial Economic Analysis. The spatial model with space-varying coefficients proposed by Sun et al. in 2014 has proved to be useful in detecting the location effects of the impacts of covariates as well as spatial interaction in empirical analysis. However, Sun et al.’s estimator is inconsistent when heteroskedasticity is present – a circumstance that is more realistic in certain applications. In this study, we propose a kind of semi-parametric generalized method of moments (GMM) estimator that is not only heteroskedasticity robust but also takes a closed form written explicitly in terms of observed data. We derive the asymptotic distributions of our estimators. Moreover, the results of Monte Carlo experiments show that the proposed estimators perform well in finite samples.
Additional file 2 of Specialist wait time reporting using family physicians’ electronic medical record data: a mixed method study of feasibility and clinical utility
Creators: name: Naimer, Michelle S.
name: Aliarzadeh, Babak
name: Bell, Chaim M.
name: Ivers, Noah
name: Jaakkimainen, Liisa
name: McIsaac, Warren
name: Meaney, Christopher
name: Moineddin, Rahim
name: Permaul, Joanne A.
name: Makuwaza, Tutsirai
name: Kukan, Sahana
Publisher: name: figshare
Year: 2022
Subjects: subject: Biotechnology
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2.
Antifungal activity of cinnamic acid and benzoic acid esters against Candida albicans strains
Creators: name: Tamires C. Lima
name: Ferreira, Alana R.
name: Silva, Daniele F.
name: Edeltrudes O. Lima
name: Damião P. De Sousa
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Candida albicans is an important opportunistic fungal pathogen capable of provoking infection in humans. In the present study, we evaluated the antifungal effect of 23 ester derivatives of the cinnamic and benzoic acids against 3 C. albicans strains (ATCC-76645, LM-106 and LM-23), as well as discuss their Structure–Activity Relationship (SAR). The antifungal assay results revealed that the screened compounds exhibited different levels of activity depending on structural variation. Among the ester analogues, methyl caffeate (5) and methyl 2-nitrocinnamate (10) were the analogues that presented the best antifungal effect against all C. albicans strains, presenting the same MIC values (MIC = 128 μg/mL), followed by methyl biphenyl-2-carboxylate (21) (MIC = 128, 128 and 256 μg/mL for C. albicans LM-106, LM-23, and ATCC-76645, respectively). Our results suggest that certain molecular characteristics are important for the antifungal action.
Societal implications of medical insurance coverage for imatinib as first-line treatment of chronic myeloid leukemia in China: a cost-effectiveness analysis
Creators: name: Sheng, Guangying
name: Chen, Suning
name: Dong, Chaohui
name: Zhang, Ri
name: Miao, Miao
name: Wu, Depei
name: Tan, Seng Chuen
name: Liu, Chao
name: Xiong, Tengbin
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Hematology

description: Objectives: Imatinib (Glivec) and nilotinib (Tasigna) have been covered by critical disease insurance in Jiangsu province of China since 2013, which changed local treatment patterns and outcomes of patients with chronic myeloid leukemia (CML). This study evaluated the long-term cost-effectiveness of insurance coverage with imatinib as the first-line treatment for patients with CML in China from a societal perspective. Methods: A decision-analytic model based on previously published and real-world evidence was applied to simulate and evaluate the lifetime clinical and economic outcomes associated with CML treatments before and after imatinib was covered by medical insurance. Incremental cost-effectiveness ratio (ICER) was calculated with both costs and quality-adjusted life years (QALYs) discounted at 3% annually. Different assumptions of treatment benefits and costs were taken to address uncertainties and were tested with sensitivity analyses. Results: In base case analysis, both cost and effectiveness of CML treatments increased after imatinib was covered by the medical insurance; on average, the incremental QALY and cost were 5.5 and ¥277,030 per patient in lifetime, respectively. The ICER of insurance coverage with imatinib was ¥50,641, which is less than the GDP per capita of China. Monte Carlo simulation resulted in the estimate of 100% probability that the insurance coverage of imatinib is cost-effective. Total cost was substantially saved at 5 years after patients initiated imatinib treatment with insurance coverage compared to no insurance coverage, the saved cost at 5 years was ¥99,565, which included the cost savings from both direct (e.g. cost of bone marrow or stem cell transplant) and indirect costs (e.g. productivity loss of patients and care-givers). Conclusions: The insurance coverage of imatinib is very cost-effective in China, according to the local cost and clinical data in Jiangsu province. More importantly, the insurance coverage of imatinib and nilotinib have changed the treatment patterns of CML patients, thus dramatically increasing life expectancy and quality-of-life (QoL) saving on productivity losses for both CML patients and their caregivers.
Additional file 3 of Specialist wait time reporting using family physicians’ electronic medical record data: a mixed method study of feasibility and clinical utility
Creators: name: Naimer, Michelle S.
name: Aliarzadeh, Babak
name: Bell, Chaim M.
name: Ivers, Noah
name: Jaakkimainen, Liisa
name: McIsaac, Warren
name: Meaney, Christopher
name: Moineddin, Rahim
name: Permaul, Joanne A.
name: Makuwaza, Tutsirai
name: Kukan, Sahana
Publisher: name: figshare
Year: 2022
Subjects: subject: Biotechnology
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 3.
Модели Блэка-Шоулса с детерминированным и случайным моментом времени изменения параметров модели
Creators: name: Сушко Степан Сергеевич
Publisher: name: Известия высших учебных заведений. Северо-Кавказский регион. Естественные науки
Year: 2010
Subjects: модель Блэка-Шоулса
винеровский процесс
преобразование Гирсанова
мартингальная мера
опцион
производная Радона-Никодима
Black-Sholes model
Wiener process
Girsanov transformation
martingale measure
Option
Radon-Nikodim derivative

description: Рассматриваются 2 обобщения модели Блэка-Шоулса для ценообразования опционов с изменяющимися в момент времени τ параметрами волатильности σ, тренда μ  и процентной ставки r. В 1-й модели τ марковский момент остановки, во 2-й P(τ = τ0) = 1.
description: We consider two generalizations of the Black-Scholes model for the computation of option prices in this article. In both of them parameters for volatility σ, trend μ and interest rate r changes at once at a time moment τ. In the first model τ is Markovian stopping time, in the second one we consider that P(τ = τ0) = 1.
Prenatally diagnosed congenital portosystemic shunts
Creators: name: Francois, Bérengère
name: Lachaux, Alain
name: Fréderic Gottrand
name: Smet, Stéphanie De
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: Computational Biology

description: Aim: Congenital portosystemic shunts (CPSS) are rare, congenital malformations that are increasingly often discovered during the fetal period, and for which, the manifestations and evolution are poorly understood. The objective of this review is to describe the phenotype and evolution of forms diagnosed in the antenatal period. Materials and methods: We performed a systematic review of the literature cited in Pubmed between 1982 and 2016 for CPSS cases diagnosed during the fetal period. Results: We identified 123 cases. The median age at diagnosis was 25 GA (14–38 weeks GA). Eighty patients had 128 associated congenital anomalies. The congenital abnormalities most frequently associated with antenatal diagnosis of CPSS were congenital cardiac disease (30 cases), intrauterine growth restriction (21 cases), vascular anomalies (14 cases), and trisomy 21 (7 cases). Seventy-five complications were reported in the literature. The most frequent were antenatal hemodynamic abnormalities (27 cases), neonatal cholestasis (11 cases), and hyperammonemia (10 cases). Twenty-nine patients had no complications. The choice of treatment was conservative in 29/56 cases, interventional radiology in 15 cases and surgery in 15 cases (three of the latter after failure of embolization). Conclusion: From this review, we propose an algorithm for the perinatal management of this congenital abnormality.
06. Transitory moments in infant/toddler play: Agentic imagination
Creators: name: Ridgway, Avis
name: Li, Liang
name: Quiñones, Gloria
Publisher: name: Monash University
Year: 2016
Subjects: subject: 130102 Early Childhood Education (excl. Maori)
subject: FOS: Educational sciences
subject: 130313 Teacher Education and Professional Development of Educators
subject: 130202 Curriculum and Pedagogy Theory and Development

description: Studying relationships in infant/toddler play, using visual narrative methodology to identify transitory moments, supports our current research on babies and toddlers. We use Vygotsky’s theorisation of play to understand children’s affective and intellectual aspirations in play. The theoretical discussion, using cultural-historical concepts, argues for identification of transitory moments as turning points for learning. Through examining transitory moments in screen- capture snapshots from video, researchers illustrate the actual worlds of infant/toddler play where personal and collective meaning, and affect and resolution, are created and located. Our study of infant/toddler relationships in play reveals several transitory moments reflecting imaginative thought in action: agentic imagination. A case example from Long Day Care brings visual narrative together with a dialogue commentary to provide meaning of the playful circumstances in which babies’ and toddlers’ “affective incentives” (Vygotsky, this issue, p. 9) are realised and resolved in imaginary situations. This paper addresses a gap existing in pedagogical awareness of what transitory moments in play can mean for infant/toddler learning and development in early childhood education.
International Research in Early Childhood Education, vol. 7, no. 2, pp. 91–110
Antibacterial activity of a triterpenoid saponin from the stems of Caesalpinia pulcherrima Linn.
Creators: name: Asati, Nidhi
name: R. N. Yadava
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: A new compound 1 was isolated from the methanolic extract of the stems of the Caesalpinia pulcherrima Linn. along with a reported compound (2) 3-O-β-D-glucopyranosyl-(1→4)-β-D-xylopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl hederagenin 28-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester. The new compound 1 has m.p. 272–274°C, m.f. C46H74O17, [M]+ m/z 898. It was characterised as 3-O-β-D-glucopyranosyl-(1→4)-α-L-arabinopyranosyl hederagenin 28-O-β-D- xylopyranosyl ester by various colour reactions, chemical degradations and spectral analyses. Antibacterial activity of compound 1 was screened against various Gram-positive and Gram-negative bacteria and showed significant results.
MODELING THE EFFECT OF MECHANIZATION LEVEL INDEX ON CROP YIELD APPROACHING SYSTEM DYNAMICS METHODOLOGY
Creators: name: Jalalzadeh, Behnam
name: Borghei, Ali Mohammad
name: Almassi, Morteza
Publisher: name: figshare
Year: 2017
Subjects: subject: 99901 Agricultural Engineering
subject: FOS: Other engineering and technologies
subject: 140201 Agricultural Economics
subject: FOS: Economics and business

description: MODELING THE EFFECT OF MECHANIZATION LEVEL INDEX ON CROP YIELD APPROACHING SYSTEM DYNAMICS METHODOLOGY
Societal implications of medical insurance coverage for imatinib as first-line treatment of chronic myeloid leukemia in China: a cost effectiveness analysis
Creators: name: Sheng, Guangying
name: Chen, Suning
name: Dong, Chaohui
name: Zhang, Ri
name: Miao, Miao
name: Depei, Wu
name: Tan, Seng Chuen
name: Liu, Chao
name: Xiong, Tengbin
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Hematology

description: Objectives: Imatinib (Glivec) and nilotinib (Tasigna) have been covered by critical disease insurance in Jiangsu province of China since 2013, which changed local treatment patterns and outcomes of patients with chronic myeloid leukemia (CML). This study evaluated the long-term cost-effectiveness of insurance coverage with imatinib as the first-line treatment for patients with CML in China from a societal perspective. Methods: A decision-analytic model based on previously published and real-world evidence was applied to simulate and evaluate the lifetime clinical and economic outcomes associated with CML treatments before and after imatinib was covered by medical insurance. Incremental cost-effectiveness ratio (ICER) was calculated with both costs and quality-adjusted life years (QALYs) discounted at 3% annually. Different assumptions of treatment benefits and costs were taken to address uncertainties and were tested with sensitivity analyses. Results: In base case analysis, both cost and effectiveness of CML treatments increased after imatinib was covered by the medical insurance, on average, the incremental QALY and cost were 5.5 and ¥277,030 per patient in lifetime, respectively. The ICER of insurance coverage with imatinib was ¥50,641, which is less than the GDP per capita of China. Monte Carlo simulation resulted in the estimate of 100% probability that the insurance coverage of imatinib is cost-effective. Total cost was substantially saved at 5 years after patients initiated imatinib treatment with insurance coverage compared to no insurance coverage, the saved cost at 5 years was ¥99,565, which included the cost savings from both direct (e.g. cost of bone marrow or stem cell transplant) and indirect costs (e.g. productivity loss of patients and care-givers). Conclusions: The insurance coverage of imatinib is very cost-effective in China, according to the local cost and clinical data in Jiangsu province. More importantly, the insurance coverage of imatinib and nilotinib have changed the treatment patterns of CML patients thus dramatically increasing life expectancy and quality of life (QoL) saving on productivity losses for both CML patients and their care givers.
Solar Regenerative High Altitude Long Endurance Aircraft Multidisciplinary Design Optimization
Creators: name: McDonnell, Taylor
name: Mehr, Judd
Publisher: name: figshare
Year: 2017
Subjects: subject: Aerospace Engineering
subject: FOS: Mechanical engineering

description: Multidisciplinary Design Optimization of a Solar Regenerative High Altitude Long Endurance Unmanned Aerial Vehicle
Additional file 1 of A cautionary signal from the Red Sea on the impact of increased dust activity on marine microbiota
Creators: name: Behzad, Hayedeh
name: Ohyanagi, Hajime
name: Alharbi, Badr
name: Ibarra, Martin
name: Alarawi, Mohammed
name: Saito, Yoshimoto
name: Duarte, Carlos M.
name: Bajic, Vladimir
name: Mineta, Katsuhiko
name: Gojobori, Takashi
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional file 1.
Supplementary Material for: Combining Virtual Touch Tissue Imaging and BI-RADS May Improve Solid Breast Lesion Evaluation
Creators: name: Wu, S.
name: Cui, X.
name: Huang, L.
name: Bai, X.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Background: Ultrasound elastography (UE) is a novel imaging method. The purpose of this study was to determine the utility of Virtual Touch tissue imaging in the evaluation of solid breast lesions. Patients and Methods: 209 breast solid lesions in 192 patients that had been evaluated using ultrasound (US) and UE were reviewed and analyzed. Results: The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value for UE, US, and US plus UE in the differentiation of malignant from benign breast lesions were 80.8, 75.6, 77.9, 73.1, and 82.8% for UE, 87.2, 86.1, 86.6, 83.7, and 89.2% for US, and 92.5, 86.9, 89.5, 85.3, and 93.4% for US plus UE. There were significant differences between UE and US plus UE (all p < 0.05). Except for accuracy, there were no significant differences between UE and US or US and US plus UE (all p > 0.05). The area under the curve obtained from the ROC curve for UE, US, and US plus UE in differentiating malignant from benign lesions was 0.845, 0.884, and 0.922, respectively. Conclusion: The UE scoring system is not superior to BI-RADS in the sonographic evaluation of solid breast lesions. Combined use may improve the performance.
Electronic Supplementary Material from Chimpanzees breed with genetically dissimilar mates
Creators: name: Walker, Kara K.
name: S. Rudicell, Rebecca
name: Li, Yingying
name: H. Hahn, Beatrice
name: Wroblewski, Emily
name: E. Pusey, Anne
Publisher: name: The Royal Society
Year: 2016

description: This single file contains detailed information on the paternity assignment procedure, including genbank numbers and a summary of paternity analyses. It also contains information on and checks of potential biases in our calculation of pairwise relatedness measures and compares our generated pairwise relatedness values to Hamilton's R for individuals of known pedigree. It contains supplementary information on two offspring; one of whom's determination of inbreeding was less precise than usual and one who was conceived in unusual circumstances. Finally, we also duplicate our results presented in the main paper using triadic likelihood pairwise relatedness values. Inbreeding adversely affects fitness, whereas heterozygosity often augments it. Therefore, mechanisms to avoid inbreeding and increase genetic distance between mates should be advantageous in species where adult relatives reside together. Here we investigate mate choice for genetic dissimilarity in chimpanzees, a species in which many females avoid inbreeding through dispersal, but where promiscuous mating and sexual coercion can limit choice when related adults reside together. We take advantage of incomplete female dispersal in Gombe National Park, Tanzania to compare mate choice for genetic dissimilarity among immigrant and natal females in two communities using pairwise relatedness measures in 135 genotyped chimpanzees. As expected, natal females were more related to adult males in their community than were immigrant females. However, among 62 breeding events, natal females were not more related to the sires of their offspring than immigrant females, despite four instances of close inbreeding. Moreover, females were generally less related to the sires of their offspring than to non-sires. These results demonstrate that chimpanzees may be capable of detecting relatedness and selecting mates on the basis of genetic distance.
title: Lettre numérisée de Marc-Philippe Daubresse envoyée le 11 septembre 2014 à Richard Cross (Les Amis d'ICCARRE) , transférée à des destinataires non révélés
Creators: name: Daubresse, Marc-Philippe (1953-....)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Source: http://www.calames.abes.fr/pub/ms/Calames-2019311113234772
Additional file 1 of Perspectives on deployment of humanitarian workers through operational partnerships during the acute emergency health response to the Rohingya refugee crisis in Cox’s Bazar
Creators: name: Blackmore, Claire
name: Evers, Egmond Samir
name: Sazed, S. M. Asif
name: Baidjoe, Amrish
name: Vilas, Victor Del Rio
name: Pesigan, Art
name: Ofrin, Roderico
Publisher: name: figshare
Year: 2022
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Additional file 1.
Optimizing theCounterweight Trebuchet for Maximum Range
Creators: name: Park, Jared
Publisher: name: figshare
Year: 2017
Subjects: subject: 120403 Engineering Design Methods
subject: FOS: Other engineering and technologies

description: We performed an optimization on the design of a counterweight trebuchet with a fixed “footprint,” or projected area. For this project, we used research performed by others, re-deriving the equations of motion ourselves, to find the best design for throwing a set projectile the greatest distance. Design variables were short arm length, sling length, weight rope length, swing clearance, starting angle and release angle. The constraints were the footprint, the height of the pivot, and the weight position, and we chose the mass of the counterweight and the mass of the projectile. We also included drag on the projectile and built a full-size model of the optimized trebuchet to get real-world data and validate our model. The optimized design launched the projectile 26.8 meters and validated our model to within an error of 6.3%.