cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Constraining the duration of ram pressure stripping features in the optical from the direction of jellyfish galaxy tails
Creators: name: Salinas, Vicente
name: Jaffé, Yara L.
name: Smith, Rory
name: Shinn, Jong-Ho
name: Crossett, Jacob P.
name: Gullieuszik, Marco
name: González-Torà, Gemma
name: Piraino-Cerda, Franco
name: Poggianti, Bianca
name: Vulcani, Benedetta
name: Biviano, Andrea
name: Lourenço, Ana C. C.
name: Bilton, Lawrence E.
name: Kelkar, Kshitija
name: Calderón-Castillo, Paula
Publisher: name: arXiv
Year: 2024
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Ram pressure stripping is perhaps the most efficient mechanism for removing gas and quenching galaxies in dense environments as they move through the intergalactic medium. Extreme examples of on-going ram pressure stripping are known as jellyfish galaxies, characterized by a tail of stripped material that can be directly observed in multiple wavelengths. Using the largest homogeneous broad-band optical jellyfish candidate sample in local clusters known to date, we measure the angle between the direction of the tails visible in the galaxies, and the direction towards the host cluster center. We find that $33\%$ of the galaxy tails point away from the cluster center, $18\%$ point towards the cluster center, and $49\%$ point elsewhere. Moreover, we find stronger signatures of ram pressure stripping happening on galaxies with a tail pointing away and towards the cluster center, and larger velocity dispersion profiles for galaxies with tails pointing away. These results are consistent with a scenario where ram pressure stripping has a stronger effect for galaxies following radial orbits on first infall. The results also suggest that in many cases, radially infalling galaxies are able to retain their tails after pericenter and continue to experience significant on-going ram pressure stripping. We further constrain the lifespan of the optical tails from the moment they first appear to the moment they disappear, by comparing the observed tail directions with matched N-body simulations through Bayesian parameter estimation. We obtain that galaxy tails appear for the first time at $\sim 1.16$ R$_{200}$ and disappear $\sim660$ Myr after pericenter.
description: 19 pages, 17 figures
The Impact of Energy Security on a German Energy System by 2030 and 2045 and the Role of Heat Pumps
Creators: name: Kost, Christoph
name: Kaiser, Markus
name: Brandes, Julian
name: Jürgens, Patrick
name: :Unav
Publisher: name: Fraunhofer-Gesellschaft
Year: 2021
Subjects: energy security
energy modeling
climate neutrality
natural gas
price

description: The recent energy crises of natural gas supply in Europe caused by the Russian invasion of the Ukraine have put a spotlight on the interdependence between the energy transition towards climate neutrality and security of supply of conventional fuels from to today until 2030 and 2035. This paper therefore assesses the impact of a sustained energy crisis and resulting higher fossil resource prices, in particular for natural gas and oil, and options for dedicated measure to reduce the dependence on imports in particular of natural gas and oil. The results are based on a common scenario approach in the ARIADNE Kopernikus project and are calculated by using the energy system REMod which was used in several important scenario studies recently. There are multiple studies analyzing the German energy transformation considering its national CO2 reduction goals, i.e. with the target of net-zero emissions in 2045 (Brandes et al. 2021; Luderer, Kost, and Dominika 2021; Prognos, Öko-Institut, and Wuppertal-Institut 2021). However, all of them have been published before the current energy crisis in 2022. A second detailed analysis of this paper is the role of heat pumps as they are a central substitution technology of natural gas in the building sector of Germany. As electricity demand by heat pumps will grow, this demand will be analyzed in a statistical analysis of the operation of heat pumps.
General Relativity and Geodesy
Creators: name: Hackmann, Eva
name: Huckfeldt, Moritz
name: Lämmerzahl, Claus
name: Philipp, Dennis
name: Rievers, Benny
Publisher: name: arXiv
Year: 2025
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Mass redistribution on Earth due to dynamic processes such as ice melting and sea level rise leads to a changing gravitational field, observable by geodetic techniques. Monitoring this change over time allows us to learn more about our planet and its dynamic evolution. In this paper, we highlight the impact of General Relativity (GR) on geodesy: it provides corrections essential for the interpretation of high-precision measurements and enables a completely novel measurement approach using chronometry, i.e., clock-based observations. Focusing on the latter, we review the construction of the relativistic gravity potential and the corresponding geoid definition as an isochronometric surface to elucidate the comparison to the conventional Newtonian geoid. Furthermore, we comment on additional potentials due to the non-Newtonian degrees of freedom of the relativistic gravitational field, and assess the feasibility of clock-based measurements for Gravity Field Recovery (GFR) from space. Although clock observations in space demonstrate technical promise for GFR, achieving the necessary precision for practical applications remains challenging.
description: Preprint of an article published in International Journal of Modern Physics D, doi:10.1142/S0218271825400115, copyright World Scientific Publishing Company, www.worldscientific.com/worldscinet/ijmpd
Polyphenol-rich strawberry tree honey inhibits cell proliferation, promotes apoptosis and ROS production, and regulates EGFR signaling pathways in HCT-116 human colon carcinoma cells
Creators: name: Afrin, Sadia
name: Forbes Hernández, Tamara Yuliett
name: Gasparrini, Massimiliano
name: Spano, Nadia
name: Sanna, Gavino
name: Giampieri, Francesca
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Objectives: To evaluate the chemopreventive activity of polyphenol-rich Strawberry tree honey, on the human colon cancer HCT-116 cell line.
 Methodology: 12 monofloral Strawberry tree honey (STH) samples were analyzed to determine their total phenolic (TP), flavonoid (TF) and protein contents as well as their total antioxidant capacity (TAC). HCT-116 cells were treated with different concentrations of the best STH sample and the cell viability was evaluated by MTT assay. It was also determined the intracellular ROS production and apoptosis rate by Tali® Image-Based Cytometer. In order to elucidate the pathway involved, the expression of different proteins related to the apoptosis (Caspase-3, p53 and PARP) and EGFR (p-AKT and p-EKR1/2) pathway was determined by western blotting.
 Results: Berchidda’s honey which showed the highest amount of TP, TF, protein and TAC was selected for treating HCT-116 cells. STH significantly reduced HCT-116 cells proliferation in a concentration-dependent manner and induced apoptosis and ROS production. After STH treatment, the Caspase-3, p-53 and PARP were significantly upregulated and EGFR, p-AKT and p-ERK1/2 signalling proteins were suppressed.
 Conclusion: STH could be a novel and promising chemotherapeutic agent in colon cancer treatment although more analysis is needed to confirm this hypothesis.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 4 (2016)
RHiOTS: A Framework for Evaluating Hierarchical Time Series Forecasting Algorithms
Creators: name: Roque, Luis
name: Soares, Carlos
name: Torgo, Luís
Publisher: name: arXiv
Year: 2024
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences
subject: I.2.6; I.5.1; G.3; H.2.8

description: We introduce the Robustness of Hierarchically Organized Time Series (RHiOTS) framework, designed to assess the robustness of hierarchical time series forecasting models and algorithms on real-world datasets. Hierarchical time series, where lower-level forecasts must sum to upper-level ones, are prevalent in various contexts, such as retail sales across countries. Current empirical evaluations of forecasting methods are often limited to a small set of benchmark datasets, offering a narrow view of algorithm behavior. RHiOTS addresses this gap by systematically altering existing datasets and modifying the characteristics of individual series and their interrelations. It uses a set of parameterizable transformations to simulate those changes in the data distribution. Additionally, RHiOTS incorporates an innovative visualization component, turning complex, multidimensional robustness evaluation results into intuitive, easily interpretable visuals. This approach allows an in-depth analysis of algorithm and model behavior under diverse conditions. We illustrate the use of RHiOTS by analyzing the predictive performance of several algorithms. Our findings show that traditional statistical methods are more robust than state-of-the-art deep learning algorithms, except when the transformation effect is highly disruptive. Furthermore, we found no significant differences in the robustness of the algorithms when applying specific reconciliation methods, such as MinT. RHiOTS provides researchers with a comprehensive tool for understanding the nuanced behavior of forecasting algorithms, offering a more reliable basis for selecting the most appropriate method for a given problem.
description: Proceedings of the 30th ACM SIGKDD Conference on Knowledge Discovery and Data Mining (KDD '24), August 25--29, 2024, Barcelona, Spain
Assessment of polyphenolic profile evolution of maqui berry (Aristotelia chilensis (Molina) Stuntz) during in vitro gastrointestinal digestion.
Creators: name: Navarro-Coves, Sergio
name: Lucas-Gonzalez, Raquel
name: Muñoz, Loreto A
name: Perez-Alvarez, José A.
name: Fernández-López, Juana
name: Viuda-Martos, Manuel
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Maqui (Aristotelia chilensis (Molina) Stuntz) is a wild edible berry that grows in Chile. These fruits are extremely rich in anthocyanins, being responsible for their intense blackish color. Thus, the aim of the present study was to determine the effect of in vitro gastrointestinal digestion (GID) on the anthocyanins profile evolution of maqui berry. The extracts obtained in each step of GID were used to determine the stability of polyphenolic profile using HPLC. The HPLC analysis of maqui berry showed a total of eight compounds identified as anthocyanins, being delphinidin and cyanidin derivatives the predominant compounds (Delphinidin-3-sambubioside-5-glucoside, Delphinidin-3,5-diglucoside, Cyanidin-3-sambubioside-5-glucoside, Cyanidin-3,5-diglucoside, Delphinidin-3-sambubioside, Delphinidin-3-glucoside, Cyanidin-3-sambubioside, Cyanidin-3-glucoside). After mouth step, all anthocyanins detected decreased the concentration (p<0.05) with respect to the initial concentration. At the end of gastric step, all compounds increased the concentration (p<0.05) with respect to mouth step. The enzyme activity or pH conditions could facilitate the breakage of large molecules as high molecular weight phenols which initially may be insoluble. At the end of intestinal step, none of these compounds was found maybe by the change in pH conditions. The results suggest that GID may alter the biological effects of maqui berry anthocyanins significantly.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 4 (2016)
Two-membrane etalon
Creators: name: Marzioni, Francesco
name: Natali, Riccardo
name: Malossi, Nicola
name: Vitali, David
name: Di Giuseppe, Giovanni
name: Piergentili, Paolo
Publisher: name: arXiv
Year: 2025
Subjects: subject: Quantum Physics (quant-ph)
subject: Applied Physics (physics.app-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Optomechanics with semi-transparent membrane multi-oscillators in a high-finesse cavity is an established solution for designing the dispersive interaction, and reaching many achievements, such as the study of non-linear dynamics, heat transfer, and so on. The multi-oscillators are dielectric slabs, usually with low reflectivity, constituting an etalon. Here we propose the theoretical and experimental investigation of a low-finesse optical cavity formed by two (nominally identical) parallel semi-transparent membranes. The experiment consists in laser-driving the cavity, detecting interferometrically the field reflected by the etalon, and measuring the intensity of the transmitted field, for different distances within the two membranes. A complete characterization of the membrane sandwich is provided. On the other hand, we developed an analytical model to describe the fields, which reproduces all the experimental results, under specific approximations. As expected, the model reproduces the known results when high-reflectivity, and/or fixed mirrors conditions are restored. This work paves the way for a complete and analytical model to describe multi-oscillators "membrane-in-the-middle" optomechanics.
description: 8 pages, 7 figures
Effect of in vitro gastrointestinal digestion on the bioaccessibility of polyphenolic compounds of flours obtained from lemon and cactus pear fruit co-products.
Creators: name: López-López, Daniel
name: Lucas-Gonzalez, Raquel
name: Sayas-Barberá, Estrella
name: Perez-Alvarez, José A.
name: Fernández-Lopez, Juana
name: Viuda-Martos, Manuel
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: The flours obtained from several co-products like lemon (Citrus lemon) or cactus pear fruit (Opuntia indica) contains a wide range of bioactive compounds mainly dietary fiber and polyphenolic compounds. In this work, the bioaccessibility of polyphenolic compounds (phenolic acids and flavonoids) present in the flours obtained from lemon (LF) and cactus pear (CPF) was tested by the application of in vitro gastrointestinal digestion. In vitro gastrointestinal digestion of samples was performed according to the method described by Mills et al. (2008) while the bioaccessibility of polyphenolic compounds was determined following the indications of Ortega et al. (2011). The bioaccessibility index of phenolic acids present in LF and CPF, at the end of intestinal digestion, were 18.25 and 46.53%, respectively with statistical differences (p<0.05) between them. The bioaccessibility of flavonoid compounds in LF and CPF, at the end of intestinal digestion, was 13.94 and 11.32% respectively, with statistical differences (p<0.05) between them. These values suggest that several changes in phenolic and flavonoid compounds like modification of chemical structure, increased or reduced solubility or interaction with other compounds might happen during the gastrointestinal digestion of co-product flours, which influence the bioaccessibility as mentioned Gullón et al. (2015).
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 4 (2016)
BIOPHENOLS CHARACTERIZATION OF EXTRA VIRGIN OLIVE OIL EXTRACTS AND IN VITRO TEST ON A MODEL OF COLORECTAL CANCER CELLS
Creators: name: Mulas, Stefano
name: Palmini, Gaia
name: Fierini, Elisa
name: Ieri, Francesca
name: Tanini, Annalisa
name: Pampaloni, Barbara
name: Brandi, Marialuisa
name: Romani, Annalisa
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Extra virgin olive oil (EVOO) is believed to exert beneficial effects against many pathological processes, including the development of colorectal cancer (CRC). It is well known that olive oil contains a variety of biophenols, which are thought to be responsible for this anti-carcinogenic effects [1]. Several studies have shown that the expression of estrogen receptor β (ERβ) is significantly reduced in colon cancer cells. To investigate the correlation between the presence of biophenols and the beneficial effects, different EVOOs have been chemical characterized and in vitro tested on a model of human colon cancer cell line HCT8-β8 [2].
 Chemical characterization of extracts was performed by HPLC/DAD/MS techniques [3]; three main categories were identified (Table 1): simple phenols, secoiridoids, and lignans. Consequently, we have evaluated the in vitro effects of the EVOOs extracts (5-75 µM) and of hydroxytyrsol (OH-Tyr) standard (5-50 µM) on HCT8-β8 [4].
 Both extracts have showed a biological activity on HCT8-β8 at the concentration of 25 µM, whereas OH-Tyr at 5 µM. Additionally, at the same concentration, EVOO2 has showed an anti-proliferative effect higher than EVOO1 (Table 2). In conclusion EVOOs extracts can inhibit the mitotic activity of colon cancer and it seems correlated to the biophenols concentration.
  ACKNOWLEDGEMENTS
 This work is supported by TrACS and TUSCANY NATURBEN projects
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 4 (2016)
Recovery of polyphenols having beneficial biological activities from red and white grape pomace
Creators: name: Tassoni, Annalisa
name: Michelini, Elisa
name: Calabretta, Maria Maddalena
name: Roda, Aldo
name: Ferri, Maura
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Grape is the world’s largest fruit crop mostly used in wine making, a process during which 20-30% of the weight ends up as pomace,  that constitutes a rich but yet underutilised source of valuable compounds. Polyphenolic compounds were extracted from red and white grape pomace and the extracts were assayed for several beneficial bioactivities. Polyphenolic compounds of wet (WP) and dried (DP) grinded pomace were recovered by enzymatic digestions and ethanol-based extractions. In general, extracts from white pomace were 1.4-fold (WP) and 7.7-fold (DP) more rich of polyphenols than those from red samples [1].
 Large concentrations of anthocyanins and flavanols were found respectively in red and white samples. Quantification of 28 specific compounds was carried on by HPLC-DAD. All the extracts showed antioxidant activity; the best red pomace samples exerted cholesterol-lowering capacity, while white extracts were tested for anti-inflammatory and anti-tyrosinase effects [1]. The results support the possibility of exploiting the extracts as ingredients for functional and innovative products in the nutraceutical, pharmaceutical, cosmetic or bioplastic fields.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 4 (2016)
Assessing Economic Transitions Study : 2023 Fall Update
Creators: name: McCormack, Deb
name: Whelan, MaryJo
name: Assessing Economic Transitions Study (ASSETS) Team
Publisher: name: The University of British Columbia
Year: 2023

description: The ASSET Study is focused on the ways people make money in the Downtown Eastside (DTES) community and how that affects their health and well-being. It was developed in collaboration with DTES economic opportunity providers to explore experiences and outcomes across the income generation spectrum. An update on the status of the ASSET Study and its planned next steps is provided in this Fall newsletter.
Sardinian parasitic plants Cytinus hypocistis and Cynomorium coccineum as effective sources of biological active compounds
Creators: name: Zucca, Paolo
name: Sanjust, Enrico
name: Rosa, Antonella
name: Nieddu, Mariella
name: Argiolas, Antonio
name: Rinaldi, Andrea C.
name: Rescigno, Antonio
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Cytinus hypocistis (Cytinaceae) and Cynomorium coccineum (Cynomoriaceae) are two Mediterranean parasitic plants, wildly diffused in Sardinia and well-known for several ethnopharmacological activities [1-2]. Nevertheless, only partially confirmation have been reported so far. To explore their potential, we undertook a thorough biological study.

 Cynomorium coccineum
 Cytinus hypocistis
 Antioxidant
 +
 ++
 Antibacterial(Gram+)
 +
 +
 Antibacterial   (Gram-)
 +/-
 +/-
 Antityrosinase
 +
 ++
 Cytotoxicity against B16F10
 +
 -
 Pro-erectile
 +
 NT
 Water and methanol extracts from both plants presented intriguing biological activities, due to a high content in phenolics (Table 1). The main active components were identified as gallic acid and cyanidin-3-O-glucoside [2]. Antioxidant activity was determined with both ET (FRAP, DPPH, and TEAC-ABTS) and HAT assays (ORAC-pyrogallol). Both plants were active against clinical isolate methicillin-resistant Staphylococcus aureus. Significant differences were found in the cytotoxic properties of the two plants. In fact, whereas Cynomorium was toxic against tumoral line B16F10, Cytinus did not have a significant effect even at the highest dose (1000μg/mL). In C. coccineum, even pro-erectile function was detected, confirming traditional use. Altogether these activities are promising in the perspective of potential nutraceutical applications.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 4 (2016)
Working with Color: How Color Quantization Can Aid Researchers of Problematic Information
Creators: name: Lutz, Nina
name: Padzensky, Jordyn W.
name: Schafer, Joseph S.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computers and Society (cs.CY)
subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: Analyzing large sets of visual media remains a challenging task, particularly in mixed-method studies dealing with problematic information and human subjects. Using AI tools in such analyses risks reifying and exacerbating biases, as well as untenable computational and cost limitations. As such, we turn to adopting geometric computer graphics and vision methods towards analyzing a large set of images from a problematic information campaign, in conjunction with human-in-the-loop qualitative analysis. We illustrate an effective case of this approach with the implementation of color quantization towards analyzing online hate image at the US-Mexico border, along with a historicist trace of the history of color quantization and skin tone scales, to inform our usage and reclamation of these methodologies from their racist origins. To that end, we scaffold motivations and the need for more researchers to consider the advantages and risks of reclaiming such methodologies in their own work, situated in our case study.
Supplementary document for Dual-Modality Hyperspectral Microscopy for Biomedical and Fluorescent Imaging - 6089118.pdf
Creators: name: Zhang, Shuyan
name: Cheng, Joseph
name: Chua, Jian Jun
name: Li, Xiuting
name: Olivo, Malini
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary information (revised)
Our Practice Newsletter : By Pharmacists For Pharmacists. Issue 34
Creators: name: Ziemczonek, Adrian
name: Domanski, Nicole
Publisher: name: The University of British Columbia
Year: 2024

description: Feature Case: Contraception Conundrum? Leveraging Your Assessment Skills for Impactful Prescribing. This case highlights how a detailed review of comorbidities and patient preferences can allow for impactful prescribing that addresses multiple health issues with a single medication.
Finding Joy
Creators: name: Sargeant, Ky
Publisher: name: The University of British Columbia
Year: 2024

description: Equity, Diversity, and Inclusion is hard work. Harder than most give it credit for. Though the mandate for EDI has grown across both public and private institutions, the gap between what is asked and the resources provided regularly places the burden of change upon those most affected by its absence. In the wake of the tech crash of 2023, we saw how EDI budgets were often among the first to be cut. A 2023 report by Revelio Labs found that EDI-focused roles “experienced a nearly 40% churn rate at companies engaged in layoffs, as compared to about 24% for non-DEI roles”, with hiring for Chief Diversity Officers now declining after the rapid uptake in 2020. However, the need for EDI remains ever-present, as many initiatives continue to be led from the ground up by passionate individuals and Employee Resource Groups, often doing so in addition to their typical responsibilities. The question for those passionate about EDI and practitioners in the field is how do we maintain the sustainability of our efforts in spite of these setbacks? And, How do we begin to inspire those around us to take the small steps needed to build our collective capacity to make inclusive change? This workshop will draw on frameworks from a range of general management and social psychology literature to explore the challenging nature of work that puts your passion on the line and how we take care of ourselves to find the capacity to keep doing it. Topics that this session covers: What is “our job” when it comes to EDI work and where do we draw the line The importance of building personal and professional support networks Finding joy and staying optimistic amidst challenging circumstances
An Interactive Augmented Reality Interface for Personalized Proxemics Modeling
Creators: name: Nigro, Massimiliano
name: O'Connell, Amy
name: Groechel, Thomas
name: Velentza, Anna-Maria
name: Matarić, Maja
Publisher: name: arXiv
Year: 2024
Subjects: subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: Understanding and respecting personal space preferences is essential for socially assistive robots designed for older adult users. This work introduces and evaluates a novel personalized context-aware method for modeling users' proxemics preferences during human-robot interactions. Using an interactive augmented reality interface, we collected a set of user-preferred distances from the robot and employed an active transfer learning approach to fine-tune a specialized deep learning model. We evaluated this approach through two user studies: 1) a convenience population study (N = 24) to validate the efficacy of the active transfer learning approach; and 2) a user study involving older adults (N = 15) to assess the system's usability. We compared the data collected with the augmented reality interface and with the physical robot to examine the relationship between proxemics preferences for a virtual robot versus a physically embodied robot. We found that fine-tuning significantly improved model performance: on average, the error in testing decreased by 26.97% after fine-tuning. The system was well-received by older adult participants, who provided valuable feedback and suggestions for future work.
description: M. Nigro, A. O'Connell, T. Groechel, A.M. Velentza and M. Matari\'c, "An Interactive Augmented Reality Interface for Personalized Proxemics Modeling: Comfort and Human-Robot Interactions," in IEEE Robotics & Automation Magazine, doi: 10.1109/MRA.2024.3415108
АНАТОМО-ФИЗИОЛОГИЧЕСКОЕ ОСОБЕННОСТИ РАЗВИТИЯ ПЛОДА В УТРОБЕ МАТЕРИ
Creators: name: Тургунова, Малика
name: Бабаджанова, Хурсаной
Publisher: name: Zenodo
Year: 2025

description: Внутриутробное развитие плода представляет собой поэтапный процесс формирования будущего организма, от зачатия до рождения. Именно в этот период формируется все основные органы и системы, происходит морфогенез, функциональная специализация и рост тканей.
Supplementary document for In-line Mach-Zehnder interferometer and Bragg grating integrated by femtosecond laser for discrimination of temperature and directional torsion - 6089862.pdf
Creators: name: Yang, Wenqing
name: Wu, Tianhao
name: Wu, Zhifang
name: Wang, Xicheng
name: Shum, Perry
name: Wang, Xiaoyan
name: Wang, Zhiyuan
name: Pu, Jixiong
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: The spectral variation of Dip1 under different torsion
title: DataCite Team Retreat 2024 – Cooking and Collaboration
Creators: name: Edmunds, Rorie
Publisher: name: DataCite
publisherIdentifier: https://ror.org/04wxnsj81
publisherIdentifierScheme: ROR
Year: 2024

description: ‘If you want to create good and tasty food, then you must have love and respect for the person who will consume it’. This was the overriding message that the DataCite Team was taught when learning to cook Moroccan food at our recent retreat, and one that is pertinent to not only serving guests in your home, but also for DataCite when developing services for the community.
Politische Bildung auf Sekundarstufe I. Erscheinungsformen und Herausforderungen am Beispiel von Unterrichtssequenzen zu «Europa – EU – Schweiz»
Creators: name: Thyroff, Julia
name: Scheller, Jan
name: Schneider, Claudia
name: Waldis Weber, Monika
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2020
Subjects: subject: 370 - Erziehung, Schul- und Bildungswesen

description: Mit Einführung des Lehrplans 21 stehen Geschichtslehrpersonen künftig vor der Herausforderung, auf Sekundarstufe I auch Politische Bildung zu unterrichten – ein Fach, das jedoch über ganz eigene Prinzipien, Perspektiven, Konzepte und Kompetenzen verfügt. Inwiefern gelingt es Lehrpersonen aktuell, diese genuin politische Fachlichkeit zu realisieren? Im Text stellen wir Ergebnisse unserer Unterrichtsanalysen vor, die wir anhand von acht Doppellektionen zum Gegenstand «Europa – EU – Schweiz», durchgeführt von vier Lehrpersonen, gewonnen haben. Wir fokussieren dabei auf zwei Aspekte: a) Inwiefern wird von den Lehrpersonen auf der Gegenstandsebene politische Fachlichkeit realisiert und b) inwieweit werden in den formulierten Arbeitsaufträgen politische Kompetenzen adressiert?
Seasonal variation in the effects of Mediterranean polyphenol extracts on the exsheathment kinetics of goat gastro-intestinal nematode larvae
Creators: name: Azaizeh, Hassan Ahmad
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: The use of chemical drugs for the control of Gastro-intestinal nematodes causes rapid development of resistance to anthelmintics in worm populations. The possible use of polyphenols from plants has been identified as a valuable solution.  However, the concentration of these bio-actives in plants can be seasonal and we hypothesized that this may cause different anthelmintic bio-activity. Using two-species Teladorsagia circumcinta and Trichostrongylus colubriformis, we tested this hypothesis by using the larval exsheathment inhibition assay. We examined effect on L3 larval exsheathment kinetics and polyphenol content of ethanol 70% extracts of Pistacia lentiscus, Phillyrea latifolia, and Inula viscosa clipped during different seasons. Extracts of P. latifolia showed similar inhibition of larval exsheathment throughout the year; in contrast, the inhibition by  both extracts of P. lentiscus and I. viscosa was affected by season, ranking fall>summer>spring=winter and spring>summer=fall>winter, respectively. The total polyphenol content in foliage of these plant species was highest in fall for P. lentiscus and in spring for I. viscosa, but did not vary significantly for P. latifolia. Differences in larval exsheathment inhibition did not completely fit differences in phenolics contents. Seasonal variation in anthelmintic activity should be taken into account where plants are integrated into anthelmintic strategies.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 4 (2016)
Perioperative application of polyphenol melanin in surgical management of patients with kidney cancer
Creators: name: Yakovlev, Pavel G.
name: Falaleyeva, Tetyana M.
name: Beregova, Tetyana V.
name: Ostapchenko, Lena
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: The management of kidney cancer (KC) patients implies multi-modal approach. Adding dietary supplements may yield additional benefit to the patient. We examine the effects of dietary polyphenol supplement “Melatal” administered perioperatively on treatment outcome in patients with KC subjected to nephrectomy.
Materials and methods. During 2014-2015 twenty patients with KC surgically treated (nephrectomy) received dietary supplement “Melatal” (vital activity product of black yeast “Nadsoniella nigra sp. X-1”) daily week before and three weeks after surgery. Controls were blood analysis of 20 patients with KC subjected to nephrectomy and placebo. Absolute lymphocyte count (ALC) and % of lymphocytes (Lph%) were analyzed before the administration of “Melatal”/placebo, on the day of surgery (day 7), and weekly postoperatively.
Results. Median ALC, Lph% prior to kidney surgery was 1.2*103/ml, 22% respectively. In study group ALC and Lph% by surgery day rose to median 3.1*103/ml and 39%, in control group were unchanged. By the day 7 postoperatively, study group showed stable lymphocyte count, in control group median ALC and median Lph% dropped to 0.9*103/ml and 17%.

Conclusion. Perioperative monthly application of dietary supplement “Melatal” (active substance: polyphenol drug melanin) in kidney cancer patients exerts curative immunostimulatory effect.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 4 (2016)
Effect of printing parameters on mechanical performance of material-extrusion 3D-printed PEEK specimens at the point-of-care
Creators: name: Zarean, Paridokht
name: Zarean, Parichehr
name: De Wild, Michael
name: Thieringer, Florian M.
name: Sharma, Neha
name: Seiler, Daniel
name: Malgaroli, Patrick
Publisher: name: MDPI
Year: 2023
Subjects: subject: 540 - Chemie

description: Additive manufacturing (AM) of polyetheretherketone (PEEK) biomaterials using the material-extrusion (MEX) method has been studied for years. Because of the challenging manufacturing process, precisely controlling printing parameters is crucial. This study aimed to investigate the effects of printing parameters such as orientation and position of printing on mechanical properties. Thus, 34 samples were printed using PEEK filament and the MEX process. Samples were divided into two main groups (A,B) according to their printing orientations (A: groups 1–3) and positions on the build plate (B: groups 4–8). Mechanical tensile tests were performed to evaluate the effects of different printing orientations and positions on mechanical properties. The means of the tensile modulus in samples 3D-printed in XY (group 1), XZ (group 2), and ZX (group 3) orientations were not significantly different (p-value = 0.063). Groups 1 and 2 had smaller distributions than group 3 in the means of tensile strength. The t-test showed that the overall means of the measurements in groups 4–8 did not differ significantly (p-value = 0.315). The tensile tests indicated that printing in vertical and horizontal orientations had no significant influence on mechanical properties. There were no significant differences in mechanical strength between top/bottom printed samples in five different lateral positions. Reliability of printing with good mechanical properties could be a step forward to manufacturing patient-specific implants.
Bio-enhancers for Improving Bioavailability of Phytochemicals
Creators: name: Choi, Inwook
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Introduction: Low bioavailability and effectiveness on target tissues of phytochemicals can limit their utilization as potent nutraceuticals. In this study, we introduced some bio-enhancers to modify absorption or hepatic metabolism of phytochemicals for increasing their bioavailability as well as improving functional properties on target tissues.
Methods: Phytochemicals and bio-enhancers were co-treated in human hepatoma HepG2 cells, human liver microsomes, cytosols and human recombinant UGT, SULT isoforms. The production of pro-inflammatory markers such as NO, PGE2, IL-1β, IL-6 and TNF-α were examined in LPS-stimulated a murine macrophage RAW264.7 cells. In addition, the anti-inflammatory activity of metabolites of phytochemicals was investigated against carrageenan-induced paw edema in mice.
Results: Bio-enhancers inhibited hepatic metabolism of phytochemicals by phase II conjugating enzymes including UGT, and SULT. Co-treatment of phytochemicals and bio-enhancers reduced the production of pro-inflammatory mediators in LPS-stimulated RAW 264.7 cells. Administration of phytochemicals and bio-enhancer also markedly attenuated paw edema formation after carrageenan injection. These results suggest that bio-enhancer plays synergistic roles in maintaining anti-inflammatory effect of phytochemicals after hepatic metabolism.
Conclusion: Our data provide a new insight on possible improvement in functional properties of phytochemicals on target cells by improving their absorption as well as modifying their metabolic pathway in hepatocytes.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 4 (2016)
Virtual Reality and Active Video Game Integration within an Intensive Bimanual Therapy Program for Children with Hemiplegia
Creators: name: Ferron, Audrey
name: Robert, Maxime T.
name: Fortin, William
name: Bau, Odette
name: Cardinal, Marie-Claude
name: Desgagné, Julie
name: Saussez, Geoffroy
name: Bleyenheuft, Yannick
name: Levac, Danielle
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Medicine
Neuroscience
Science Policy
Virology
Computational Biology

description: To describe the nature of custom and non-custom virtual reality and active video game (VR/AVG) implementation within a Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE) intervention program for children with hemiplegia. Six children aged 8-11 years participated in a 10-day HABIT-ILE intervention (65 h; 6.5 planned VR/AVG hours). VR/AVG implementation details were recorded daily and summarized with descriptive statistics; active motor engagement was quantified as minutes of active game participation. Post-intervention interviews with interventionists were analyzed with qualitative content analysis. On average, participants received 79% of the planned VR/AVG dosage (314/400 planned minutes, range 214–400 min), of which the per-session active motor engagement average was 68% (27 min, SD 12 min). Participation involved equivalent amounts of custom (49%) and non-custom (51%) VR/AVG system use. Material and verbal adaptations facilitated alignment with HABIT-ILE principles. Interventionists identified type of task (gross versus fine motor), children’s perceived motivation, and VR/AVG attributes as factors influencing active motor engagement and alignment with HABIT-ILE principles. Describing individual and technological challenges of VR/AVG integration within HABIT-ILE can advance knowledge about VR/AVG use in intensive interventions and identify directions for subsequent research.
Charting everyday activities in later life. Study protocol of the mobility, activity, and social interactions study (MOASIS)
Creators: name: Röcke, Christina
name: Luo, Minxia
name: Bereuter, Pia
name: Katana, Marko
name: Fillekes, Michelle
name: Gehriger, Victoria
name: Sofios, Alexandros
name: Martin, Mike
name: Weibel, Robert
Publisher: name: Frontiers Research Foundation
Year: 2023
Subjects: subject: Mobility
subject: Physical acitivity
subject: Social interactions
subject: Cognitive activities
subject: Ambulatory assessment
subject: Functional ability
subject: GIS
subject: GPS
subject: Psychology
subject: FOS: Psychology
subject: Gerontopsychology
subject: Gerontology
subject: Study design
subject: 150 - Psychologie

description: Prominent theories of aging emphasize the importance of resource allocation processes as a means to maintain functional ability, well-being and quality of life. Little is known about which activities and what activity patterns actually characterize the daily lives of healthy older adults in key domains of functioning, including the spatial, physical, social, and cognitive domains. This study aims to gain a comprehensive understanding of daily activities of community-dwelling older adults over an extended period of time and across a diverse range of activity domains, and to examine associations between daily activities, health and well-being at the within- and between-person levels. It also aims to examine contextual correlates of the relations between daily activities, health, and well-being. At its core, this ambulatory assessment (AA) study with a sample of 150 community-dwelling older adults aged 65 to 91 years measured spatial, physical, social, and cognitive activities across 30 days using a custom-built mobile sensor (“uTrail”), including GPS, accelerometer, and audio recording. In addition, during the first 15 days, self-reports of daily activities, psychological correlates, contexts, and cognitive performance in an ambulatory working memory task were assessed 7 times per day using smartphones. Surrounding the ambulatory assessment period, participants completed an initial baseline assessment including a telephone survey, web-based questionnaires, and a laboratory-based cognitive and physical testing session. They also participated in an intermediate laboratory session in the laboratory at half-time of the 30-day ambulatory assessment period, and finally returned to the laboratory for a posttest assessment. In sum, this is the first study which combines multi-domain activity sensing and self-report ambulatory assessment methods to observe daily life activities as indicators of functional ability in healthy older adults unfolding over an extended period (i.e., 1 month). It offers a unique opportunity to describe and understand the diverse individual real-life functional ability profiles characterizing later life.
Collagenase, Elastase and Hyaluronidase Inhibitory Activities of Some Polyphenols Isolated from Ononidis Radix
Creators: name: Ergene Oz, Burcin
name: Saltan Iscan, Gülçim
name: Akkol, Esra
name: Bahadir Acikara, Ozlem
name: Suntar, Ipek
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: The genus Ononis L. which belongs to Fabaceae family, is represented by more than 75 species in Europe as well as Atlantic Islands, West Asia and North Africa. The genus is especially distributed closed to the coasts of Mediterranean Sea (Al-Khalil, 1995; Reyes-Betancort & Scholz, 2008). Ononis spinosa L. is a well known species especially in the central region of Turkey and the roots of this species is used as folk medicine against skin diseases due to its wound healing activity (Altanlar et al., 2006; Sever Yılmaz et al., 2006).
In this study, in vitro collagenase, elastase and hyaluronidase inhibitory activities of five polyphenolic compounds, namely trifolirhizin, ononin, medicarpin-3-O-glucoside, onogenin-7-O-glucoside and sativanone-7-O-glucoside, were evaluated. The compounds were isolated from the ethylacetate fraction of the roots of O. spinosa and the structure of the bioactive compounds were established by MS, 1H- and 13C-NMR as well as 2D-NMR (COSY, TOCSY, HSQC, HMBC) techniques.

According to the results; among the tested compounds, ononin and sativanone-7-O-glucoside were found to possess hyaluronidase and elastase inhibitory activity. At the dose of 100 μg/ml, ononin showed %31.66 hyaluronidase inhibitory activity and %41.75 elastase inhibitory activity; as the results were found to be %45.58 and %46.88 sativanone-7-O-glucoside, respectively.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 4 (2016)
In vitro study of DNA protecting effects of polyphenols against hydroxyl radical produced in Fenton reaction
Creators: name: Sjakste, Nikolajs
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Environmental genotoxic stress produces numerous hazards including DNA lesions. Thus search for remedies capable to protect DNA and increase radioresistance in humans appears to be a topical problem. Aim of this study was to test the DNA-protecting activity of four natural compounds (quercetin, myricetin, indole-3-carbinol and ipriflavone). PTZ57R plasmid DNA was isolated from Escherichia coli strain DH5alpha. DNA breaks were caused by the Fenton reaction. Fenton reaction mixture was formed in 10 μl by combining following substances: plasmid DNA (0.2 μg), 0.003% hydrogen peroxide, ferrous sulfate, 0.01 mM phosphate buffer, and the analyte in 5, 10, 25, 50, 100 µM concentrations. Bands on the gel were analyzed with the GelAnalyzer2010a program. Quercetin, myricetin and indole-3-carbinol were effective in preventing Fenton reaction-induced oxidative DNA damage. Quercetin was most effective in concentrations 5μM and 10μM, myricetin - 10μM and indole-3-carbinol - 5μM. Ipriflavone in concentration-dependent manner, manifested a statistically significant DNA protective capacity from H2O2-induced oxidative damage at 1μM, 5μM and 10μM concentrations. The latter semi-synthetic compound appears to be a prospective radio protective drug.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 4 (2016)
Effects of myricetin and a 1,4-dihydropiridien derivative on expression of NO synthase genes and DNA breakage in intact and diabetic rats
Creators: name: Sjakste, Tatjana
name: Osina, Kristine
name: Rostoka, Evita
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Nitrosative stress caused by eNOS uncoupling and iNOS overexpression as well as DNA breakage are important in pathogenesis of Type 1 diabetes mellitus (T1DM). Search for novel remediescorrecting above effects is a topical biomedical problem. We have performed a study of iNos and eNos gene expressionnd DNA brekage after administration of  myricetin and 1,4-dihydropyridine derivative AV-153-Na to animals with experimental DM.

eNos gene expression in kidneys of diabetic animals was decreased by 30% compared to controls. Myricetin increased the eNos gene expression in kidneys of control animals. In diabetics myricetin and AV-153-Na produced similar effect.

iNos expression increased after induction of diabetes. Myricetin and the combination up-regulated the gene expression in control animals to the level comparable to that in diabetic rats. In diabetic animals none of the three treatments could normalize expression of the gene.

Both myricetin and AV-153-Na given separately or in combination increased level of DNA breakage in white blood cells of both intact and diabetic animals.

Our data indicate co-existence of both favorable and unfavorable effects of myricetin and AV-153-Na on NO synthase gene expression and DNA breakage in T1DM.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 4 (2016)
Literature as a Mirror of History and Society: A Case Study of OkeyNdibe'sArrows of Rain
Creators: name: Kenneth Obinna, Patrick
Publisher: name: Zenodo
Year: 2024

description: To know History is to be forearmed.Literature is one of the most excellent tools and gift of society. While many writers write to entertain, literature can achieve much more than the entertainment function. It also exposes to and informs the reader about events that happened in the past. It is not out of point to say that history, which is the society’s memory, should go hand-in-hand with literature to the end that community would be informed, educated, and armed. Through literature, the entirety of humanity is further revealed and bared to the people. In this study, we shall discuss the relationship between literature and history and their impact and relevance to society, using the text, Arrows of Rain by OkeyNdibe.Keywords: arrows of rain, history, literature, historiography, okeyndibe, society