cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Role of IL‐17 in atopy—A systematic review
Creators: name: Hofmann, Maja A.
name: Fluhr, Joachim W.
name: Ruwwe‐Glösenkamp, Christoph
name: Stevanovic, Katarina
name: Bergmann, Karl‐Christian
name: Zuberbier, Torsten
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: allergische Erkrankung
subject: atopische Dermatitis
subject: Atopie
subject: Überempfindlichkeit
subject: IL-17
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose of Review: Atopy is defined as the genetic predisposition to react with type I allergic diseases such as food-, skin-, and respiratory allergies. Distinct molecular mechanisms have been described, including the known Th2 driven immune response. IL-17A (IL-17) is mainly produced by Th17 cells and belongs to the IL-17 family of cytokines, IL-17A to F. While IL-17 plays a major role in inflammatory and autoimmune disorders, more data was published in recent years elucidating the role of IL-17 in allergic diseases. The present study aimed to elaborate specifically the role of IL-17 in atopy. Methods: A systematic literature search was conducted in MEDLINE, Embase, and Cochrane Central Register of Controlled Trials, regarding IL-17 and atopy/allergic diseases. Results: In total, 31 novel publications could be identified (food allergy n = 3, allergic asthma n = 7, allergic rhinitis [AR] n = 10, atopic dermatitis [AD] n = 11). In all allergic diseases, the IL-17 pathway has been investigated. Serum IL-17 was elevated in all allergic diseases. In AR, serum and nasal IL-17 levels correlated with the severity of the disease. In food allergies, serum IL-17E was also elevated in children. In AD, there is a trend for higher IL-17 values in the serum and skin specimen, while it is more expressed in acute lesions. In allergic asthma, serum IL-17 levels were increased. In two studies, higher serum IL-17 levels were found in severe persistent asthmatic patients than in intermittent asthmatics or healthy controls. Only one therapeutic clinical study exists on allergic diseases (asthma patients) using a monoclonal antibody against the IL-17 receptor A. No clinical efficacy was found in the total study population, except for a subgroup of patients with (post-bronchodilator) high reversibility. Summary: The role of IL 17 in the pathogenesis of allergic diseases is evident, but the involvement of the Th17 cytokine in the pathophysiological pathway is not conclusively defined. IL-17 is most likely relevant and will be a clinical target in subgroups of patients. The current data indicates that IL-17 is elevated more often in acute and severe forms of allergic diseases.
Cytosolic DNA Promotes Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation by TANK-binding Kinase 1 (TBK1) to Restrain STAT3 Activity
Creators: name: Baldwin, Albert S.
name: Hutti, Jessica E.
name: Hsia, Hung-Ching
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Cytosolic DNA can elicit beneficial as well as undesirable immune responses. For example, viral or microbial DNA triggers cell-intrinsic immune responses to defend against infections, whereas aberrant cytosolic accumulation of self-DNA results in pathological conditions, such as autoimmunity. Given the importance of these DNA-provoked responses, a better understanding of their molecular mechanisms is needed. Cytosolic DNA engages stimulator of interferon genes (STING) to activate TANK-binding kinase 1 (TBK1), which subsequently phosphorylates the transcription factor interferon regulatory factor 3 (IRF3) to promote interferon expression. Recent studies have reported that additional transcription factors, including nuclear factor κB (NF-κB) and signal transducer and activator of transcription 6 (STAT6), are also activated by cytosolic DNA, suggesting that cytosolic DNA-induced gene expression is orchestrated by multiple factors. Here we show that cytosolic DNA activates STAT3, another member of the STAT family, via an autocrine mechanism involving interferon β (IFNβ) and IL-6. Additionally, we observed a novel cytosolic DNA-induced phosphorylation at serine 754 in the transactivation domain of STAT3. Upon cytosolic DNA stimulation, Ser 754 is directly phosphorylated by TBK1 in a STING-dependent manner. Moreover, Ser 754 phosphorylation inhibits cytosolic DNA-induced STAT3 transcriptional activity and selectively reduces STAT3 target genes that are up-regulated in response to cytosolic DNA. Taken together, our results suggest that cytosolic DNA-induced STAT3 activation via IFNβ and IL-6 is restrained by Ser 754 phosphorylation of STAT3. Our findings reveal a new signaling axis downstream of the cytosolic DNA pathway and suggest potential interactions between innate immune responses and STAT3-driven oncogenic pathways.
Sonnenfleckenzeichnung Nr. 27.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 08.02.2008, 08:30, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2008

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
title: Case Report of Vigabatrin Related MRI Changes
Creators: name: Prematunga, Kurundeniya
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2016
Subjects: subject: Neuroradiology brain
subject: Paediatric
subject: MR
subject: Education
subject: Toxicity
subject: Education and training
subject: Seizure disorders

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: Highlight the potential neurotoxicity in patients on Vigabatrin, especially infants on relatively high doses and suggest consideration of medication related causes of MRI abnormalities that are reversible with drug discontinuation.MRI abnormalities...
Sonnenfleckenzeichnung Nr. 91.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 22.04.2008, 07:30, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2008

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Sonnenfleckenzeichnung Nr. 223.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 17.09.2008, 06:15, erstellt von Michele Bianda
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2008

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 2.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
title: General Anaesthesia for Interventional Radiology Procedures: An Audit of Current Practice
Creators: name: Craft, Melissa
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2016
Subjects: subject: Patterns of Care
subject: Acute
subject: Audit and standards
subject: Catheter arteriography
subject: Interventional non-vascular
subject: Interventional vascular

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Interventional radiology (IR) is a growing specialty, which offers both diagnostic and therapeutic benefits. Every day across Australia and worldwide, more complex procedures are being developed, performed, and incorporated into radiologists’...
Bidens chodatii Hassl., Repert. 2018, Spec. Nov.
Creators: name: Chocarro, María Del Carmen Peña
name: Egea, Juana De
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Asterales
Asteraceae
Bidens
Bidens chodatii

description: Bidens chodatii Hassl., Repert. Spec. Nov. Regni Veg. 12: 369. 1913.
Herb.
 Vouchers: Amambay: Basualdo 4885 (FCQ). Paraguarí: Fiebrig 571, type (BM, G, K); Hassler 3757, type (G). San Pedro: Basualdo 4831 (G).
description: Published as part of Chocarro, María Del Carmen Peña & Egea, Juana De, 2018, Checklist of the endemic vascular plants of Paraguay, pp. 448-450 in Phytotaxa 384 (1) on pages 448-450, DOI: 10.11646/phytotaxa.384.1.1, http://zenodo.org/record/13725946
Sonnenfleckenzeichnung Nr. 293.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 24.12.2008, 09:00, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2008

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Sonnenfleckenzeichnung Nr. 129.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 07.06.2008, 12:00, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2008

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Some Remarks on Glaisher-Ramanujan Type Integrals
Creators: name: Patkowski, Alexander E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: Some integrals of the Glaisher-Ramanujan type are established in a more general form than in previous studies. As an application we prove some Ramanujan-type series identities, as well as a new formula for the Dirichlet beta function at the value $s=3.$
Transmission pathways of campylobacter spp. at broiler farms and their environment in Brandenburg, Germany
Creators: name: Reichelt, Benjamin
name: Szott, Vanessa
name: Epping, Lennard
name: Semmler, Torsten
name: Merle, Roswitha
name: Roesler, Uwe
name: Friese, Anika
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: campylobacter
subject: environment
subject: transmission
subject: broiler
subject: WGS
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

description: Broiler meat is widely known as an important source of foodborne Campylobacter jejuni and Campylobacter coli infections in humans. In this study, we thoroughly investigated transmission pathways that may contribute to possible Campylobacter contamination inside and outside broiler houses. For this purpose we carried out a comprehensive longitudinal sampling approach, using a semi-quantitative cultivation method to identify and quantify transmissions and reservoirs of Campylobacter spp.. Three german broiler farms in Brandenburg and their surrounding areas were intensively sampled, from April 2018 until September 2020. Consecutive fattening cycles and intervening downtimes after cleaning and disinfection were systematically sampled in summer and winter. To display the potential phylogeny of barn and environmental isolates, whole genome sequencing (WGS) and bioinformatic analyses were performed. Results obtained in this study showed very high Campylobacter prevalence in 51/76 pooled feces (67.1%) and 49/76 boot swabs (64.5%). Average counts between 6.4 to 8.36 log10MPN/g were detected in pooled feces. In addition, levels of 4.7 and 4.1 log10MPN/g were detected in boot swabs and litter, respectively. Samples from the barn interior showed mean Campyloacter values in swabs from drinkers 2.6 log10MPN/g, walls 2.0 log10MPN/g, troughs 1.7 log10MPN/g, boards 1.6 log10MPN/g, ventilations 0.9 log10MPN/g and 0.7 log10MPN/g for air samples. However, Campylobacter was detected only in 7/456 (1.5%) of the environmental samples (water bodies, puddles or water-filled wheel tracks; average of 0.6 log10MPN/g). Furthermore, WGS showed recurring Campylobacter genotypes over several consecutive fattening periods, indicating that Campylobacter genotypes persist in the environment during downtime periods. However, after cleaning and disinfection of the barns, we were unable to identify potential sources in the broiler houses. Interestingly, alternating Campylobacter genotypes were observed after each fattening period, also indicating sources of contamination from the wider environment outside the farm. Therefore, the results of this study suggest that a potential risk of Campylobacter transmission may originate from present environmental sources (litter and water reservoirs). However, the sources of Campylobacter transmission may vary depending on the operation and farm environmental conditions.
Use of preprint articles in prevention research – a mixed-methods approach - update
Creators: name: Ratajczak, Piotr
name: Sommer, Isolde
name: Griebler, Ursula
name: Klerings, Irma
name: Dobrescu, Andreea
name: Sunder-Plassmann, Vincent
name: Gartlehner, Gerald
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Public Health
subject: Community Health and Preventive Medicine
subject: Medicine and Health Sciences
subject: medRxiv
subject: Preprints
subject: Prevention
subject: Survey

description: During the initial study regarding the use of preprint articles in prevention research (https://osf.io/cnkdw), where we compared the effect sizes and conclusion of preprints with their published articles (initial objective 3), we realised that we still do not know why certain preprints never get published. To address this issue, we will explore the reasons for the non-publication of preprints in peer-reviewed journals and authors' attitudes towards preprints in general.
title: Assessment and Predictors of Fatigue in Men Receiving Radiotherapy and Androgen Deprivation Therapy for Prostate Cancer
Creators: name: Bandara, Vindya
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2016
Subjects: subject: Toxicity
subject: Outcomes
subject: Cancer
subject: Radiation therapy / Oncology
subject: Health policy and practice
subject: MR
subject: Oncology
subject: Genital / Reproductive system male

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Fatigue is a commonly reported symptom in patients receiving radiation therapy and androgen deprivation therapy (ADT) for prostate cancer [1]. It is a major cause of reduced quality of life in cancer patients, with detrimental consequences for...
Plasma calcitonin gene‐related peptide (CGRP) in migraine and endometriosis during the menstrual cycle
Creators: name: Raffaelli, Bianca
name: Overeem, Lucas Hendrik
name: Mecklenburg, Jasper
name: Hofacker, Maxi Dana
name: Knoth, Henriette
name: Nowak, Claus Peter
name: Neeb, Lars
name: Ebert, Andreas Dietmar
name: Sehouli, Jalid
name: Mechsner, Sylvia
name: Reuter, Uwe
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Calcitonin Gene-Related Peptide
subject: Endometriosis
subject: Longitudinal Studies
subject: Menstrual Cycle
subject: Migraine Disorders
subject: Peptide Fragments
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objective: Migraine, endometriosis, and the comorbidity of both are frequent pain disorders of special relevance for women. The neuropeptide calcitonin gene-related peptide (CGRP) is critically involved in migraine, and circumstantial evidence suggests a role in endometriosis. We assessed CGRP levels at different times of menstrual cycle in four groups: healthy women, women with migraine or endometriosis and with the comorbidity of both. Methods: Women with episodic migraine and women with a histologically confirmed endometriosis were recruited from specialized centers. For CGRP determination with a commercial enzyme immunoassay kit, cubital vein blood samples were collected on menstrual cycle day 2 ± 2 (during menstruation) and on day 15 ± 2 (periovulatory period). The primary endpoint of the study was the absolute difference of CGRP plasma levels between the menstrual and the periovulatory phase of all study groups. Groups were compared using nonparametric test procedures. Results: A total of 124 women were included in the study. The change of CGRP plasma levels between menstruation and the periovulatory period was different between groups (p = 0.007). Women with comorbid migraine and endometriosis showed an increase of CGRP in the menstrual phase of +6.32 (interquartile range, IQR −3.64–13.60) compared to the periovulatory time, while healthy controls had a decrease of −10.14 (−22.54–0.91, p = 0.004). CGRP levels were different in the periovulatory phase among groups (p = 0.008), with highest values in healthy controls. Interpretation: CGRP levels change significantly during the menstrual cycle. Different patterns in women with the comorbidity point to a deviant regulation of CGRP release.
title: Gallium-68 PSMA PET/CT and PET/MRI for Staging Prostate Cancer: Factors Associated with Tumour Detection Rate
Creators: name: Rai, Divyajeet
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2016
Subjects: subject: Oncology
subject: Pelvis
subject: PET-CT
subject: PET-MR
subject: Radiation therapy / Oncology
subject: Metastases

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: The expression of prostate specific membrane antigen (PSMA) is increased in prostatic carcinoma. PSMA PET/CT is used in the clinical setting for detecting primary tumour and/or distant metastases. Clinical settings include 1) staging of patients...
Calea formosa Chodat, Bull. Herb. Boissier
Creators: name: Chocarro, María Del Carmen Peña
name: Egea, Juana De
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Asterales
Asteraceae
Calea
Calea formosa

description: Calea formosa Chodat, Bull. Herb. Boissier, sér. 2(2): 396. 1902.
Herb.
 Vouchers: Amambay: Hassler 9785 (F); Solomon 6882 (SI). Canindeyú: Hassler 4943 (BM, G, K, P, S). Concepción: Pedersen 14644 (SI).
description: Published as part of Chocarro, María Del Carmen Peña & Egea, Juana De, 2018, Checklist of the endemic vascular plants of Paraguay, pp. 448-450 in Phytotaxa 384 (1) on pages 448-450, DOI: 10.11646/phytotaxa.384.1.1, http://zenodo.org/record/13725946
Down-regulation of Insulin Receptor Substrate 1 during Hyperglycemia Induces Vascular Smooth Muscle Cell Dedifferentiation
Creators: name: White, Morris F.
name: Clemmons, David R.
name: Wai, Christine
name: Xi, Gang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Diabetes is a major risk factor for the development of atherosclerosis, but the mechanism by which hyperglycemia accelerates lesion development is not well defined. Insulin and insulin-like growth factor I (IGF-I) signal through the scaffold protein insulin receptor substrate 1 (IRS-1). In diabetes, IRS-1 is down-regulated, and cells become resistant to insulin. Under these conditions, the IGF-I receptor signals through an alternate scaffold protein, SHPS-1, resulting in pathophysiologic stimulation of vascular smooth muscle cell (VSMC) migration and proliferation. These studies were undertaken to determine whether IRS-1 is functioning constitutively to maintain VSMCs in their differentiated state and, thereby, inhibit aberrant signaling. Here we show that deletion of IRS-1 expression in VSMCs in non-diabetic mice results in dedifferentiation, SHPS-1 activation, and aberrant signaling and that these changes parallel those that occur in response to hyperglycemia. The mice showed enhanced sensitivity to IGF-I stimulation of VSMC proliferation and a hyperproliferative response to vascular injury. KLF4, a transcription factor that induces VSMC dedifferentiation, was up-regulated in IRS-1−/− mice, and the differentiation inducer myocardin was undetectable. Importantly, these changes were replicated in wild-type mice during hyperglycemia. These findings illuminate a new function of IRS-1: that of maintaining cells in their normal, differentiated state. Because IRS-1 is down-regulated in states of insulin resistance that occur in response to metabolic stresses such as obesity and cytokine stimulation, the findings provide a mechanism for understanding how patients with metabolic stress and/or diabetes are predisposed to developing vascular complications.
Effect of doping on the electronic properties of Graphene and T-graphene : A theoretical approach
Creators: name: Sadhukhan, Banasree
name: Nayak, Arabinda
name: Mookerjee, Abhijit
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: In this communication we present together four distinct techniques for the study of electronic structure of solids : the tight-binding linear muffin-tin orbitals (TB-LMTO), the real space and augmented space recursions and the modified exchange-correlation. Using this we investigate the effect of random vacancies on the electronic properties of the carbon hexagonal allotrope, graphene, and the non-hexagonal allotrope, planar T graphene. We have inserted random vacancies at different concentrations, to simulate disorder in pristine graphene and planar T graphene sheets. The resulting disorder, both on-site (diagonal disorder) as well as in the hopping integrals (off-diagonal disorder), introduces sharp peaks in the vicinity of the Dirac point built up from localized states for both hexagonal and non-hexagonal structures. These peaks become resonances with increasing vacancy concentration. We find that in presence of vacancies, graphene-like linear dispersion appears in planar T graphene and the cross points form a loop in the first Brillouin zone similar to buckled T graphene that originates from $π$ and $π$* bands without regular hexagonal symmetry. We also calculate the single-particle relaxation time, $τ(\vec{q})$ of $\vec{q}$ labeled quantum electronic states which originates from scattering due to presence of vacancies, causing quantum level broadening.
title: To warn or not to warn? Trigger warnings in arts, humanities and social sciences in UK HE
Creators: name: Boyle, Karen
name: McCarry, Melanie
name: House, Melody
Publisher: name: Strathprints - University of Strathclyde
Year: 2025

description: Although gender-based violence (GBV) in HE has received considerable attention recently, this has not, typically, extended to a concern with how experiences of GBV impact on student engagement with content about GBV. On the other hand, the emerging research evidence around trigger warnings in HE has not addressed GBV in a consistent way. This article thus aims to bring feminist work on GBV into the trigger warning debate. Drawing on our online survey of 525 teaching staff and focus groups with 42 staff and student-survivors of GBV, we argue for an epistemological shift that encourages a sharing of responsibility and an acknowledgment that there are survivors in all classrooms.
Spin-2 Form Factors at Three Loop in QCD
Creators: name: Ahmed, Taushif
name: Das, Goutam
name: Mathews, Prakash
name: Rana, Narayan
name: Ravindran, V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Spin-2 fields are often candidates in physics beyond the Standard Model namely the models with extra-dimensions where spin-2 Kaluza-Klein gravitons couple to the fields of the SM. Also, in the context of Higgs searches, spin-2 fields have been studied as an alternative to the scalar Higgs boson. In this article, we present the complete three loop QCD radiative corrections to the spin-2 quark-antiquark and spin-2 gluon-gluon form factors in SU(N) gauge theory with $n_f$ light flavors. These form factors contribute to both quark-antiquark and gluon-gluon initiated processes involving spin-2 particle in the hadronic reactions at the LHC. We have studied the structure of infrared singularities in these form factors up to three loop level using Sudakov integro-differential equation and found that the anomalous dimensions originating from soft and collinear regions of the loop integrals coincide with those of the electroweak vector boson and Higgs form factors confirming the universality of the infrared singularities in QCD amplitudes.
description: 20 pages, 2 figures
Acute porphyrias – A neurological perspective
Creators: name: Gerischer, Lea M.
name: Scheibe, Franziska
name: Nümann, Astrid
name: Köhnlein, Martin
name: Stölzel, Ulrich
name: Meisel, Andreas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: acute porphyria
subject: autoimmune encephalitis
subject: Guillain-Barre syndrome
subject: porphyric encephalopathy
subject: porphyric neuropathy
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Acute hepatic porphyrias (AHP) can cause severe neurological symptoms involving the central, autonomic, and peripheral nervous system. Due to their relative rarity and their chameleon-like presentation, delayed diagnosis and misdiagnosis are common. AHPs are genetically inherited disorders that result from heme biosynthesis enzyme deficiencies and comprise four forms: acute intermittent porphyria (AIP), variegate porphyria (VP), hereditary coproporphyria (HCP), and ALA-dehydratase porphyria (ALADP). Depending on the clinical presentation, the main differential diagnoses are Guillain-Barré syndrome and autoimmune encephalitis. Red flags that could raise the suspicion of acute porphyria are neurological symptoms starting after severe (abdominal) pain, in association with reddish urine, hyponatremia or photodermatitis, and the presence of encephalopathy and/or axonal neuropathy. We highlight the diagnostic difficulties by presenting three cases from our neurological intensive care unit and give a comprehensive overview about the diagnostic findings in imaging, electrophysiology, and neuropathology.
Sonnenfleckenzeichnung Nr. 77.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 01.04.2008, 07:30, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2008

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Sonnenfleckenzeichnung Nr. 296.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 27.12.2008, 09:00, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2008

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Sonnenfleckenzeichnung Nr. 149.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 30.06.2008, 07:15, erstellt von Marco Cagnotti
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2008

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
A Generalized Method for Measuring Weak Lensing Magnification With Weighted Number Counts
Creators: name: Gillis, Bryan
name: Taylor, Andy
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present a derivation of a generalized optimally-weighted estimator for the weak lensing magnification signal, including a calculation of errors. With this estimator, we present a local method for optimally estimating the local effects of magnification from weak gravitational lensing, using a comparison of number counts in an arbitrary region of space to the expected unmagnified number counts. We show that when equivalent lens and source samples are used, this estimator is simply related to the optimally-weighted correlation function estimator used in past work and vice-versa, but this method has the benefits that it can calculate errors with significantly less computational time, that it can handle overlapping lens and source samples, and that it can easily be extended to mass-mapping. We present a proof-of-principle test of this method on data from the CFHTLenS, showing that its calculated magnification signals agree with predictions from model fits to shear data. Finally, we investigate how magnification data can be used to supplement shear data in determining the best-fit model mass profiles for galaxy dark matter haloes. We find that at redshifts greater than z ~ 0.6, the inclusion of magnification can often significantly improve the constraints on the components of the mass profile which relate to galaxies' local environments relative to shear alone, and in high-redshift, low- and medium-mass bins, it can have a higher signal-to-noise than the shear signal.
description: 20 pages, 10 figures, submitted to MNRAS, first revision
Calea rojasiana Chodat, Bull. Herb. Boissier
Creators: name: Chocarro, María Del Carmen Peña
name: Egea, Juana De
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Asterales
Asteraceae
Calea
Calea rojasiana

description: Calea rojasiana Chodat, Bull. Herb. Boissier sér. 2(3): 728. 1903.
Herb.
 Vouchers: Concepción: Hassler 7390, type (G). Cordillera: Mereles 1247 (SI). Misiones: Soria 665 (FCQ). Paraguarí: Hicken & Rojas 5449, type (AS, LP, SI).
description: Published as part of Chocarro, María Del Carmen Peña & Egea, Juana De, 2018, Checklist of the endemic vascular plants of Paraguay, pp. 448-450 in Phytotaxa 384 (1) on pages 448-450, DOI: 10.11646/phytotaxa.384.1.1, http://zenodo.org/record/13725946
Sonnenfleckenzeichnung Nr. 262.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 08.11.2008, 08:30, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2008

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
A Jones matrix formalism for simulating three-dimensional polarized light imaging of brain tissue
Creators: name: Menzel, Miriam
name: Michielsen, Kristel
name: De Raedt, Hans
name: Reckfort, Julia
name: Amunts, Katrin
name: Axer, Markus
Publisher: name: arXiv
Year: 2015
Subjects: subject: Medical Physics (physics.med-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The neuroimaging technique three-dimensional polarized light imaging (3D-PLI) provides a high-resolution reconstruction of nerve fibres in human post-mortem brains. The orientations of the fibres are derived from birefringence measurements of histological brain sections assuming that the nerve fibres - consisting of an axon and a surrounding myelin sheath - are uniaxial birefringent and that the measured optic axis is oriented in direction of the nerve fibres (macroscopic model). Although experimental studies support this assumption, the molecular structure of the myelin sheath suggests that the birefringence of a nerve fibre can be described more precisely by multiple optic axes oriented radially around the fibre axis (microscopic model). In this paper, we compare the use of the macroscopic and the microscopic model for simulating 3D-PLI by means of the Jones matrix formalism. The simulations show that the macroscopic model ensures a reliable estimation of the fibre orientations as long as the polarimeter does not resolve structures smaller than the diameter of single fibres. In the case of fibre bundles, polarimeters with even higher resolutions can be used without losing reliability. When taking the myelin density into account, the derived fibre orientations are considerably improved.
description: 20 pages, 8 figures
Endoplasmic reticulum stress–induced degradation of DNAJB12 stimulates BOK accumulation and primes cancer cells for apoptosis
Creators: name: Ren, Hong Yu
name: Cyr, Douglas M.
name: Sopha, Pattarawut
name: Grove, Diane E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: DNAJB12 (JB12) is an endoplasmic reticulum (ER)-associated Hsp40 family protein that recruits Hsp70 to the ER surface to coordinate the function of ER-associated and cytosolic chaperone systems in protein quality control. Hsp70 is stress-inducible, but paradoxically, we report here that JB12 was degraded by the proteasome during severe ER stress. Destabilized JB12 was degraded by ER-associated degradation complexes that contained HERP, Sel1L, and gp78. JB12 was the only ER-associated chaperone that was destabilized by reductive stress. JB12 knockdown by siRNA led to the induction of caspase processing but not the unfolded protein response. ER stress-induced apoptosis is regulated by the highly labile and ER-associated BCL-2 family member BOK, which is controlled at the level of protein stability by ER-associated degradation components. We found that JB12 was required in human hepatoma cell line 7 (Huh-7) liver cancer cells to maintain BOK at low levels, and BOK was detected in complexes with JB12 and gp78. Depletion of JB12 during reductive stress or by shRNA from Huh-7 cells was associated with accumulation of BOK and activation of Caspase 3, 7, and 9. The absence of JB12 sensitized Huh-7 to death caused by proteotoxic agents and the proapoptotic chemotherapeutic LCL-161. In summary, JB12 is a stress-sensitive Hsp40 whose degradation during severe ER stress provides a mechanism to promote BOK accumulation and induction of apoptosis.
Construction and validation of a scale of sexual self-concept for the elderly Chilean population
Creators: name: Ramirez-Perez, Mauricio
name: Ferrer, Rodrigo
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences
subject: sexual self-concept, elderly, scale, sexuality

description: Sexual self-concept has a central role in the life of the elderly. Indeed, their sexual self-concept has significant and positive relationships with satisfaction with life, pleasure and willingness to interact with others. However, based on social-cultural prejudice, the elderly are considered asexual individuals, harming their sexual self-concept. This prejudice is relevant in Chile, where the elderly do not have clear information about their sexuality. However, Chilean elderly research is still in its infancy and requires more attention. Hence, this research aims to construct and validate a scale of sexual self-concept for the elderly Chilean population to cover this identified gap in the literature. Sixty items were integrated into the first version of the scale. Ten external judges were asked to assess the content validity. Twenty-eight items were maintained. Subsequently, an instrumental and cross-sectional design was implemented with a non-probabilistic sampling (N = 188). Items were refined with corrected homogeneity indices and conditional estimates of Cronbach's alpha and Omega coefficient. A final scale of 9-items equally distributed in three dimensions was obtained: Sexual self-efficacy (ω = 0.867), Sexual assertiveness (ω = 0.764), and Sexual self-esteem (ω = 0.803). The confirmatory factor analysis reflects that the theoretical model has an adequate fit (CFI = .989; TLI = .984; RMSEA = .086). The data analyses confirmed that the scale has adequate psychometric properties. This scale can be used for multidimensional measurements of sexual self-concept in the elderly in Chile. Further research can confirm its psychometric properties in different settings within the Spanish language population.
Alexithymia and Emotion Differentiation in Uncertain Circumstances
Creators: name: Dalton, Belinda
name: Koval, Peter
name: Moeck, Ella
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Psychology
subject: FOS: Psychology
subject: Social and Behavioral Sciences
subject: alexithymia
subject: daily diary
subject: emotion differentiation

description: This study explores how self-reported trait alexithymia is associated with emotion differentiation in daily life, assessed using both participant-generated (idiographic) and researcher-generated (standard) measures of affective experience. This is a specific research question that was part of a larger data collection. The larger data collection pre-registration, which contains all study details and full data collection protocol, is available at https://osf.io/tq3gc
Sonnenfleckenzeichnung Nr. 292.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 23.12.2008, 09:30, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2008

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
"What do they call me?" : quilting aesthetics in the music of the Black Arts Movement
Creators: name: Buffington-Anderson, Heather Nicole
Publisher: name: The University of Texas at Austin
Year: 2022
Subjects: Music
Black Arts Movement
Jazz
Gender

description: It is clear from the foundational theoretical texts and subsequent scholarship that music is at the center of the Black Arts Movement discourse. Discussions have primarily focused on the insistence from Black Arts theorists to look to Black music as the standard for Black expression to develop a Black Aesthetic. Theorists often located free jazz as the standard for Black Arts cultural production. As a result, the experimental sounds of the jazz avant-garde became the representative music of radical Black politics of the 1960s and 1970s. Recent scholarship underlines the dominant narratives of Blackness and radical Black politics of the Black Power era privilege heterosexual Black masculinity. This has rendered the participation of Black women artist-activists invisible within the movement. Influenced by this scholarship, I reorient discussions of Black Arts music by exploring the participation of jazz vocalists. By focusing on musicians at the margins of jazz, this project aims to expand and complicate notions of Black radicalism, Black aesthetics, as well as the chronology of the Black Arts Movement. This dissertation explores the music and activism of Oscar Brown Jr., Betty Carter, Abbey Lincoln, and Nina Simone by focusing on Black aesthetic strategies, collaborations, reception, and identity. I develop a theory of a quilting aesthetic to discuss how artists-activists move between genres and forms as an act of subversion and resistance. The lens of a quilting aesthetic supplements discussions of a Black Aesthetic that privileges primarily Black male jazz musicians associated with the experimentalism of avant-garde jazz. I argue that quilting, as an aesthetic and activist strategy, can bring into relief the ways these artist-activists obscure conventional binaries to challenge divisions between jazz and popular, masculinity and femininity, and blackness and whiteness. Ultimately, within this dissertation, I aim to highlight how dominant notions of the Black Aesthetic are gendered masculine. Resituating Brown Jr., Carter, Lincoln, and Simone within the Black Arts discourse does not simply increase the roster of musicians within the movement. Rather, I aim to reconfigure and complicate notions of Black radicalism and the jazz avant-garde by underlining multiple Black aesthetics within the Black Arts Movement.
New 3,3-disubstituted oxetanes and azetidines: Synthesis, evaluation and new opportunities for drug discovery
Creators: name: Dubois, Maryne Andrée Jacqueline
Publisher: name: Imperial College London
Year: 2020

description: 3,3-Disubstituted oxetanes and azetidines are valuable motifs with attractive physichochemical properties and are potential replacement groups for gem-dimethyl, carbonyls and larger heterocycles. The development of robust methods to access such scaffolds is highly desirable. In this thesis, novel 3,3-disubstituted oxetanes and azetidines are prepared through the in situ generation of carbocations and radicals. The suitability of these new motifs for drug discovery programmes is also evaluated. In this regard, 3,3-diaryloxetanes are first assessed as replacement groups for diarylketones and 1,1-diarylalkanes in part 3. These oxetanes are synthesised through a Friedel–Crafts reaction with oxetanols. The comparison of the physicochemical properties between 3,3-diaryloxetanes, benzophenones and 1,1-diarylalkanes shows that these oxetanes are suitable replacements groups for medicinal chemistry application. The preparation of new 3,3-diarylazetidines and 3-arylsulfanyl-azetidines is then described in part 4. This was achieved through in situ generation of azetidinyl carbocations from NCbz-azetidin-3-ols using Ca and Fe catalysts. These carbocations can react with nucleophiles such as (hetero)aromatics and thiols giving new azetidine scaffolds in high yields. The generation of oxetanyl and azetidinyl carbocations required the alcohol precursors to bear electron-rich aromatics. An alternative Fe-catalysed Friedel–Crafts reaction is then described in part 5, where the use of hexafluoroisopropanol as solvent enables oxetanyl carbocation formation from oxetanols bearing phenyl and electron-poor aromatics. Previously inaccessible 3,3-diaryloxetanes are synthesised as well as one example of 3,3-diarylazetidine and 3-arylsulfanyl-oxetane. New oxetane and azetidine scaffolds are then prepared through in situ generation of radicals in part 6. This was achieved through photoredox-catalysed decarboxylation of oxetane and azetidine carboxylic acid precursors. The radicals are trapped with alkenes to give new 3-aryl-3-alkyl oxetanes and azetidines. A two-step protocol is also described to efficiently access the acid precursors. This involves the preparation of 3-aryl-3-furanyl intermediates through Friedel–Crafts reaction followed by oxidative cleavage of the furan.