Additional file 1 of Exploring the host factors affecting asymptomatic Plasmodium falciparum infection: insights from a rural Burkina Faso study
Creators: name: Neyer, Peter J.
name: Kaboré, Bérenger
name: Nakas, Christos T.
name: Hartmann, Britta
name: Post, Annelies
name: Diallo, Salou
name: Tinto, Halidou
name: Hammerer-Lercher, Angelika
name: Largiadèr, Carlo R.
name: van der Ven, Andre J.
name: Huber, Andreas R.
Publisher: name: figshare
Year: 2024
Subjects: subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Table S1. Frequency of combined haemoglobin genotypes HBA1/HBA2 and HBB genes (total n = 805). Table S2. Frequency of all 21 haemoglobin genotypes covered by the strip assays (Viennalab alpha-Globin for HBA, total samples n = 805), two individuals showed co-inheritance of more than one mutation. Table S3. Frequency of all 22 haemoglobin genotypes covered by the strip assay (Viennalab beta-Globin MED for HBB, total samples n = 805), 16 individuals showed co-inheritance of more than one mutation. Table S4. Univariate logistic regression results of parasitaemia as response variable. Table S5. Univariate linear regression results of parasite density as response variable. Table S6. Multivariable logistic regression of parasitaemia as response variable (total n = 688). The overall probability of parasitaemia was 56%. Figure S1. Relationship of anaemia and asymptomatic malaria parasitaemia (log10 of parasite density). (A) A lower parasite density in the non-anaemic group is documented (p &lt; 0.001, n = 384). (B) Lower haemoglobin concentrations are documented for the aparasitaemic group (p = 0.02, n = 688). Figure S2. Parasitaemia positive frequency for the basic anaemia categories (age-related total haemoglobin cut-offs) is plotted in bars and lines describing 95% CI from binomial distribution. A similar difference as in Fig. S3 (A) is observed as the parasitaemia and parasite density both appear lower in the non-anaemic group. Figure S3. Inflammation marker concentrations (log10 transformed) are illustrated and grouped by qualitative parasitaemia categories (n = 688). Highly significant differences are observed for all the parameters. Figure S4. Positive parasitaemia frequency for the gametocytaemia categories (cut-off of 1.3/µL was previously defined in the literature, [27]) is plotted in bars and lines with 95% CI from binomial distribution as lines. Differences are non-significant. Gametocytaemia is similarly prevalent in the non-parasitised group in this investigated endemic region. Figure S5. Body mass index is illustrated in a dot plot with box plots overlayed grouped by categories of nutritional status (n = 688). Individuals were categorised depending on their age, and upper-arm circumference or body mass index. For the group &lt; 19 years malnutrition status was determined by MUAC-for-age z-score and for the adult group of 20 years and older body mass index classification was used. Both variables were calculated and previously published cut-offs applied.