cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Generation of integration free induced pluripotent stem cells from fibrodysplasia ossificans progressiva (FOP) patients from urine samples
Creators: name: Hildebrand, Laura
name: Rossbach, Bella
name: Kühnen, Peter
name: Gossen, Manfred
name: Kurtz, Andreas
name: Reinke, Petra
name: Seemann, Petra
name: Stachelscheid, Harald
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Fibrodysplasia ossificans progressiva (FOP) is an extremely rare, autosomal dominant transmitted genetic disease. Patients experience progressive bone formation replacing tendons, ligaments, muscle and soft tissue. Cause of FOP are gain-of-function mutations in the Bone Morphogenetic Protein (BMP) receptor Activin A receptor type 1 (ACVR1) ( Kaplan et al., 2008). The most common mutation is R206H, which leads to the substitution of codon 206 from arginine to histidine (Shore et al., 2006). Here, we describe the derivation and characterization of two hiPSC lines from two FOP patients, both carrying the mutation R206H. Cells were isolated from urine and reprogrammed using integration free Sendai virus vectors under defined conditions.
The 2dF galaxy redshift survey: The blue galaxy fraction and implications for the Butcher-Oemler effect
Creators: name: De Propris, Roberto
name: Colless, Matthew
name: Peacock, John A.
name: Couch, Warrick
name: Driver, Simon P.
name: Balogh, Michael L.
name: Baldry, Ivan K.
name: Baugh, Carlton M.
name: Bland-Hawthorn, Joss
name: Bridges, Terry
name: Cannon, Russell
name: Cole, Shaun
name: Collins, Chris
name: Cross, Nicholas
name: Dalton, Gavin
name: Efstathiou, George
name: Ellis, Richard S.
name: Frenk, Carlos S.
name: Glazebrook, Karl
name: Hawkins, Edward
name: Jackson, Carole
name: Lahav, Ofer
name: Lewis, Ian
name: Lumsden, Stuart
name: Maddox, Steve
name: Madgwick, Darren
name: Norberg, Peder
name: Percival, Will
name: Peterson, Bruce A.
name: Sutherland, Will
name: Taylor, Keith
Publisher: name: Swinburne
Year: 2024

description: We derive the fraction of blue galaxies in a sample of clusters at z < 0.11 and the general field at the same redshift. The value of the blue fraction is observed to depend on the luminosity limit adopted, cluster-centric radius and, more generally, local galaxy density, but it does not depend on cluster properties. Changes in the blue fraction are due to variations in the relative proportions of red and blue galaxies but the star formation rate for these two galaxy groups remains unchanged. Our results are most consistent with a model where the star formation rate declines rapidly and the blue galaxies tend to be dwarfs and do not favour mechanisms where the Butcher-Oemler effect is caused by processes specific to the cluster environment.
Growing Playful, Never Lonely : Ludic Landscapes : Weaving Playfulness into the Fabric of Urban Placemaking among Older Adults with Dementia
Creators: name: Windrem, Kaitlin
Publisher: name: The University of British Columbia
Year: 2025

description: My graduate project explores the integration of playful, intergenerational spaces into urban placemaking, with a focus on older adult communities with dementia. Inspired by the principles of ludic landscapes (refer to page 07 for key terms), it argues that urban environments often fail to address the cognitive, social, and sensory needs of aging populations, especially in cities like Victoria, BC, where a significant percentage of the population are those 65 years-of-age and older. The goal of this project is to emphasize the importance of play as a tool to combat loneliness, while enhancing mental and physical well-being. By examining precedent studies and urban planning frameworks, this research highlights the potential for play-centered interventions to create inclusive, adaptable public spaces. The design for the site will explore sensory elements and cognitive engagement tools to challenge the perceptions of public space and promote more dementia-inclusive communities. The site for these interventions will be selected in Victoria’s downtown core, reflecting its aging population and unique city structure.
title: Heterogeneity of Leishmania donovani Parasites Complicates Diagnosis of Visceral Leishmaniasis
title: Comparison of Different Serological Tests in Three Endemic Regions
titleType: Subtitle
Creators: name: Abass, Elfadil
name: Kang, Cholho
name: Martinkovic, Franjo
name: Semião-Santos, Saul J.
name: Sundar, Shyam
name: Walden, Peter
name: Piarroux, Renaud
name: Harith, Abdallah El
name: Lohoff, Michael
name: Steinhoff, Ulrich
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften

description: Diagnostic tests for visceral leishmaniasis that are based on antigens of a single Leishmania strain can have low diagnostic performance in regions where heterologous parasites predominate. The aim of this study was to investigate and compare the performance of five serological tests, based on different Leishmania antigens, in three endemic countries for visceral leishmaniasis. A total number of 231 sera of symptomatic and asymptomatic cases and controls from three endemic regions of visceral leishmaniasis in East Sudan, North India and South France were evaluated by following serological tests: rKLO8- and rK39 ELISA, DAT (ITMA-DAT) and two rapid tests of rK39 (IT LEISH) and rKE16 (Signal-KA). Overall, rKLO8- and rK39 ELISA were most sensitive in immunocompetent patients from all endemic regions (96–100%) and the sensitivity was reduced to 81.8% in HIV co-infected patients from France. Sera of patients from India demonstrated significantly higher antibody responses to rKLO8 and rK39 compared with sera from Sudan (p<0.0001) and France (p<0.0037). Further, some Indian and Sudanese patients reacted better with rKLO8 than rK39. Sensitivity of DAT (ITMA-DAT) was high in Sudan (94%) and India (92.3%) but low in France being 88.5% and 54.5% for VL and VL/HIV patients, respectively. In contrast, rapid tests displayed high sensitivity only in patients from India (96.2%) but not Sudan (64–88%) and France (73.1–88.5% and 63.6–81.8% in VL and VL/HIV patients, respectively). While the sensitivity varied, all tests showed high specificity in Sudan (96.7–100%) and India (96.6%).Heterogeneity of Leishmania parasites which is common in many endemic regions complicates the diagnosis of visceral leishmaniasis. Therefore, tests based on homologous Leishmania antigens are required for particular endemic regions to detect cases which are difficult to be diagnosed with currently available tests.
Copernicus für das Umweltmonitoring
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2018

description: "Copernicus für das Umweltmonitoring" enthält ausführliche Informationen zu Copernicus, aktuelle Anwendungsbeispiele und eine kleine Übung zur ersten Verarbeitung von Sentineldaten. Quelle: HP des Hrsg.
Probing the Sensing Properties of Organic Thin Film Devices at Room Temperature
Creators: name: Ali, Salman
Publisher: name: Swinburne
Year: 2024

description: This thesis focuses on the fabrication and characterisation of humidity and gas sensors operating at room temperature based on a new class of organic semiconductor. Two different types of sensors - capacitive and amperometric - have been fabricated and an extensive study of sensitivity, selectivity and stability of these sensors at different operating frequencies undertaken. The results have widespread implications in areas of industrial engineering and chemical process control to agriculture and nature conservation, to personal health monitoring, smart cities, and national defence.
Early New Ischemic Lesions Located Outside the Initially Affected Vascular Territory Appear More Often in Stroke Patients with Elevated Glycated Hemoglobin (HbA1c)
Creators: name: Braemswig, Tim Bastian
name: Nolte, Christian H.
name: Fiebach, Jochen B.
name: Usnich, Tatiana
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: stroke
subject: diabetes mellitus
subject: hemoglobin A
subject: glycosylated
subject: magnetic resonance imaging
subject: new ischemic lesions
subject: diffusion magnetic resonance imaging
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background: Early new ischemic lesions are common in patients with an acute ischemic stroke. These new ischemic lesions may represent the natural course of the initial stroke or de novo events. Objective: We hypothesized that early new ischemic lesions located outside the initially affected vascular territory would point at de novo events. Therefore, we differentiated new ischemic lesions located outside the initially affected vascular territory from those occurring only inside the initially affected vascular territory to identify risk factors that are associated with de novo events. Methods: Stroke patients underwent three magnetic resonance imaging examinations (at 3-T): on admission, on the next day and 4–7 days after symptom onset (clinicaltrials.gov: NCT00715533). Diffusion-weighted imaging (DWI) lesions were delineated, coregistered, and then analyzed for new hyperintensities on follow-up examinations by raters blinded to clinical details. Patients were classified as having “new distant lesions” if new DWI lesions appeared outside or both outside and inside the initially affected vascular territory or “new local lesions” if they were only inside. Results: 115 patients with early new DWI lesions constitute the study population. Sixteen patients (14%) had new distant lesions and 99 patients (86%) had new local lesions. In comparison between patients with new distant and new local lesions, patients with new distant lesions had significantly more often elevated glycated hemoglobin (HbA1c ≥ 6.5%; p = 0.022). Conclusion: Our data indicate that patients with elevated HbA1c have an increased risk for new, de novo ischemic lesions in the acute phase after an ischemic stroke.
title: Grüne Produkte in Deutschland
title: Grüne Produkte in Deutschland
titleType: AlternativeTitle
Creators: name: Schwegler, Regina
name: Spescha, Gina
Publisher: name: My University
Year: 2013
Subjects: subject: Nachhaltiger Konsum
subject: Nachhaltigkeit
subject: Konsumverhalten
subject: Nachhaltigkeitsindikator
subject: Marktforschung
subject: Konsum
subject: Datengewinnung
subject: Datensammlung
subject: Ökonomische Instrumente
subject: Produkte
subject: Grüne Ökonomie
subject: Klimafreundlicher Konsum
subject: Konsumgut
subject: Wirtschaft
subject: Wirtschaft | Konsum
subject: Economy | Consumption

description: Der vorliegende Bericht trägt erstmalig Marktzahlen zu umweltverträglichen Produkten aus verschiedenen Konsumfeldern für Deutschland zusammen. Dabei geht es nicht nur um die meist im Vordergrund stehende Frage, ob die Umsatzzahlen für „grüne“ Produkte steigen. Der Bericht beantwortet auch die wichtige Frage, ob umweltverträgliche Produkte aufholen, d. h. Marktanteile gegenüber den konventionellen Varianten gewinnen. Dies ist eine wesentliche Voraussetzung dafür, dass die mit dem Konsum verbundenen Umweltbelastungen tatsächlich sinken. Er analysiert in einem weiteren Schritt auch die Umweltbelastungen, die aus einzelnen Konsumfeldern resultieren, sowie die Marktdynamiken eben dieser Konsumfelder.Der Bericht liefert wichtige Erkenntnisse für eine systematische Marktbeobachtung ökologischer Produkte und Dienstleistungen. Er schafft eine notwendige Voraussetzung für eine verbraucherorientierte Umweltpolitik. Diese kann auf Basis dieses Berichts das Marktgeschehen objektiver beurteilen und Maßnahmen zur Förderung nachhaltigen Konsums hinsichtlich ihrer Wirksamkeit besser einschätzen.Inzwischen liegt auch eine englische Fassung des Berichts vor. Diese enthält aktualisierte Daten (Bezugsjahr 2012) und zusätzliche Informationen zu Aspekten einer umweltbezogenen europäischen Produktpolitik.Daten aus den Jahren 2008 bis 2015 finden Sie in der Ausgabe 2017.
CO2-Emissionsfaktoren für fossile Brennstoffe
Creators: name: Juhrich, Kristina
Publisher: name: Umweltbundesamt
Year: 2022
Subjects: subject: Kohlendioxid
subject: Treibhausgasinventar
subject: CO2
subject: Emissionsfaktoren
subject: Fossile Brennstoffe
subject: Klima | Energie

description: Deutschland ist verpflichtet, jährlich die nationalen Emissionen der Treibhausgase an die Europäische Union und an die Vereinten Nationen zu berichten. Über 80 % der berichteten Treibhausgasemissionen in Deutschland entstehen aus der Verbrennung fossiler Brennstoffe, zum weit überwiegenden Teil in Form von Kohlendioxid. Um die Kohlendioxid-Emissionen zu berechnen benötigt man neben den Aktivitätsdaten auch passende Emissionsfaktoren, diese hängen wiederum von der Brennstoffqualität und der eingesetzten Menge ab. Aufgrund der Relevanz dieser Quellen werden für das deutsche Inventar keine internationalen Durchschnittswerte verwendet, sondern landesspezifische Emissionsfaktoren. Für deren Bestimmung ist eine umfangreiche Kenntnis der Brennstoffzusammensetzung, insbesondere der Kohlenstoffgehalte und Heizwerte unbedingt nötig. Die folgende Veröffentlichung gibt einen Überblick über die Qualität der wichtigsten in Deutschland eingesetzten Brennstoffe und die daraus berechneten CO2-Emissionsfaktoren. Da die Treibhausgasemissionen bis 1990 zurück berechnet werden müssen, werden auch Brennstoffe untersucht, die aktuell nicht mehr eingesetzt werden. Dazu werden Archivdaten verwendet, im Falle von Datenlücken werden Methoden angewendet, die eine Rückrechnung bis zum Basisjahr ermöglichen. Quelle: www.umweltbundesamt.de
description: Deutschland ist verpflichtet, jährlich die nationalen Emissionen der Treibhausgase an die Europäische Union und an die Vereinten Nationen zu berichten. Über 80 % der berichteten Treibhausgasemissionen in Deutschland entstehen aus der Verbrennung fossiler Brennstoffe, zum weit überwiegenden Teil in Form von Kohlendioxid. Um die Kohlendioxid-Emissionen zu berechnen benötigt man neben den Aktivitätsdaten auch passende Emissionsfaktoren, diese hängen wiederum von der Brennstoffqualität und der eingesetzten Menge ab. Aufgrund der Relevanz dieser Quellen werden für das deutsche Inventar keine internationalen Durchschnittswerte verwendet, sondern landesspezifische Emissionsfaktoren. Für deren Bestimmung ist eine umfangreiche Kenntnis der Brennstoffzusammensetzung, insbesondere der Kohlenstoffgehalte und Heizwerte unbedingt nötig.Die folgende Veröffentlichung gibt einen Überblick über die Qualität der wichtigsten in Deutschland eingesetzten Brennstoffe und die daraus berechneten CO2-Emissionsfaktoren. Da die Treibhausgasemissionen bis 1990 zurück berechnet werden müssen, werden auch Brennstoffe untersucht, die aktuell nicht mehr eingesetzt werden. Dazu werden Archivdaten verwendet, im Falle von Datenlücken werden Methoden angewendet, die eine Rückrechnung bis zum Basisjahr ermöglichen.
title: Association of screen time with self-perceived attention problems and hyperactivity levels in French students
title: a cross-sectional study
titleType: Subtitle
Creators: name: Montagni, Ilaria
name: Guichard, Elie
name: Kurth, Tobias
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Objective To investigate whether high levels of screen time exposure are associated with self-perceived levels of attention problems and hyperactivity in higher education students. Design Cross-sectional study among participants of the i-Share cohort. Setting French-speaking students of universities and higher education institutions. Participants 4816 graduate students who were at least 18 years old. Exposure Screen time was assessed by self-report of the average time spent on five different screen activities on smartphone, television, computer and tablet and categorised into quartiles. Main outcome measure We used the Attention Deficit Hyperactivity Disorder Self-Report Scale (ASRS-v1.1) concerning students’ behaviour over the past 6 months to measure self-perceived levels of attention problems and hyperactivity. Responses were summarised into a global score as well as scores for attention problems and hyperactivity. Results The 4816 participants of this study had a mean age of 20.8 years and 75.5% were female. Multivariable ordinary regression models showed significant associations of screen time exposure with quintiles of the total score of self-perceived attention problems and hyperactivity levels as well as the individual domains. Compared to the lowest screen time exposure category, the ORs (95% CI) were 1.58 (1.37 to 1.82) for each increasing level of quintiles of the global score, 1.57 (1.36 to 1.81) for increasing quintiles of attention levels and 1.25 (1.09 to 1.44) for increasing quartiles of hyperactivity. Conclusions Results of this large cross-sectional study among French university and higher education students show dose-dependent associations between screen time and self-perceived levels of attention problems and hyperactivity. Further studies are warranted to evaluate whether interventions could positively influence these associations.
title: Utilidad clínica de la angiografía por  CT  como procedimiento  inicial  en la hemorragia  digestiva baja aguda
Creators: name: Martí De Gracia, Milagros
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Haemorrhage
subject: Diagnostic procedure
subject: CT-Angiography
subject: Emergency

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
El objetivo es determinar la utilidad clínicade la angiografía por TC cuando se utiliza como procedimin¡entoinicial en pacientes con hemorragia digestiva baja...
title: Anatomía del hueso temporal. Guía para residentes
Creators: name: Larrazabal Echevarria, Eneritz
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Congenital
subject: Normal variants
subject: CT-High Resolution
subject: Anatomy

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
La interpretación de los estudios de oído es una tarea que ha resultado típicamente dificultosa para los residentes.
Esto es debido a que se encuentran alojadas en un hueso que contienenumerosas estructuras,
que además son de pequeño tamaño...
Smart Cities werden nachhaltig: Empfehlungen für den Bund
Creators: name: Keppner, Benno
name: Kahlenborn, Walter
name: Libbe, Jens
Publisher: name: Umweltbundesamt
Year: 2022
Subjects: Klimaschutz
Ressourcenerhaltung

description: Kommunen entwickeln zunehmend "smarte" Konzepte und Lösungen, die auf Klima-, Umwelt- und Ressourcenschutz abzielen. Nicht selten wird dabei eine Vision einer Smart City als Schlüssel zu nachhaltigeren Städten gezeichnet. Ihr Beitrag zum urbanen Umweltschutz ist in der Praxis allerdings noch wenig untersucht. Da Kommunen jedoch eine zentrale Rolle beim Erreichen lokaler sowie globaler Umwelt-, Klima- und Nachhaltigkeitsziele spielen, sollten Umweltaspekte auch in Smart-City-Ansätzen künftig noch stärker integriert werden. Das Vorhaben hat den Beitrag "smarte Lösungen" zu bestehenden Umwelt- und Nachhaltigkeitsstrategien beleutchtet. Ein weiterer Fokus lag auf der internationalen Normung und Standardisierung im Smart City Kontext. Quelle: www.umweltbundesamt.de
description: Municipalities are increasingly developing "smart" concepts and solutions aimed at climate mitigation, environmental and resource protection. The aim of the three-year project (October 2017 - September 2020) was to investigate the contribution of "smart solutions" to environmental and sustainability strategies. In 2019, four case studies in municipalities were conducted. A further focus of the project was the issue of international standardization in the field of smart cities. Quelle: www.umweltbundesamt.de
title: Thought Insertion as a Self-Disturbance
title: An Integration of Predictive Coding and Phenomenological Approaches
titleType: Subtitle
Creators: name: Sterzer, Philipp
name: Mishara, Aaron L.
name: Voss, Martin
name: Heinz, Andreas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: self-disorders
subject: first rank symptoms
subject: schizophrenia
subject: phenomenological psychiatry
subject: Bayesian inference
subject: predictive coding
subject: Mayer-Gross
subject: mescaline
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Current theories in the framework of hierarchical predictive coding propose that positive symptoms of schizophrenia, such as delusions and hallucinations, arise from an alteration in Bayesian inference, the term inference referring to a process by which learned predictions are used to infer probable causes of sensory data. However, for one particularly striking and frequent symptom of schizophrenia, thought insertion, no plausible account has been proposed in terms of the predictive-coding framework. Here we propose that thought insertion is due to an altered experience of thoughts as coming from “nowhere”, as is already indicated by the early 20th century phenomenological accounts by the early Heidelberg School of psychiatry. These accounts identified thought insertion as one of the self-disturbances (from German: “Ichstörungen”) of schizophrenia and used mescaline as a model-psychosis in healthy individuals to explore the possible mechanisms. The early Heidelberg School (Gruhle, Mayer-Gross, Beringer) first named and defined the self- disturbances, and proposed that thought insertion involves a disruption of the inner connectedness of thoughts and experiences, and a “becoming sensory” of those thoughts experienced as inserted. This account offers a novel way to integrate the phenomenology of thought insertion with the predictive coding framework. We argue that the altered experience of thoughts may be caused by a reduced precision of context-dependent predictions, relative to sensory precision. According to the principles of Bayesian inference, this reduced precision leads to increased prediction-error signals evoked by the neural activity that encodes thoughts. Thus, in analogy with the prediction-error related aberrant salience of external events that has been proposed previously, “internal” events such as thoughts (including volitions, emotions and memories) can also be associated with increased prediction-error signaling and are thus imbued with aberrant salience. We suggest that the individual’s attempt to explain the aberrant salience of thoughts results in their interpretation as being inserted by an alien agent, similarly to the emergence of delusions in response to the aberrant salience of sensory stimuli.
Boden schützen leicht gemacht
Creators: name: Meiser, Monika
name: Lahaye, Lara
name: Schmidt, Katharina
Publisher: name: My University
Year: 2019
Subjects: subject: Bodenschutz
subject: Gartenbau
subject: Nahrungsproduktion
subject: Boden
subject: Bodenlebensraumfunktion
subject: Nahrungsmittelanbau
subject: Bodendüngung
subject: bodenschonendes Bauen
subject: Boden | Fläche

description: Unser Boden ist ein echter Superheld. Auf ihm wachsen unsere Nahrungsmittel, er speichert Wasser und Nährstoffe, er schützt uns vor Überschwemmungen und er kann das ⁠Treibhausgas⁠ Kohlendioxid binden, damit es nicht in die ⁠Atmosphäre⁠ gelangt. Aber auch Helden brauchen Verbündete. Doch wie werden wir zu echten Verbündeten? Was können wir konkret für den Boden tun? Die Broschüre vermittelt konkrete Anregungen und Tipps, wie jeder und jede von uns mit kleinen, aber äußerst effektiven Taten unsere Lebensgrundlage Boden im Garten, im Alltag und beim Bauen schützen und erhalten kann. Sie basiert auf einer Zusammenarbeit des ⁠UBA⁠ mit der Deutschen Bodenkundlichen Gesellschaft (DBG), dem Bundesverband Boden e.V. (BVB), dem Ingenieurtechnischen Verband für Altlastenmanagement und Flächenrecycling (ITVA) und dem Bodenbündnis Europäischer Städte, Kreise und Gemeinden (ELSA).
Using a meta-narrative literature review and focus groups with key stakeholders to identify perceived challenges and solutions for generating robust evidence on the effectiveness of treatments for rare diseases
Creators: name: Tingley, Kylie
name: Coyle, Doug
name: Graham, Ian D.
name: Sikora, Lindsey
name: Chakraborty, Pranesh
name: Wilson, Kumanan
name: Mitchell, John J.
name: Stockler, Sylvia
name: Potter, Beth K.
Publisher: name: BioMed Central
Year: 2018

description: Introduction: For many rare diseases, strong analytic study designs for evaluating the efficacy and effectiveness of interventions are challenging to implement because of small, geographically dispersed patient populations and underlying clinical heterogeneity. The objective of this study was to integrate perspectives from published literature and key rare disease stakeholders to better understand the perceived challenges and proposed methodological approaches to research on clinical interventions for rare diseases. Methods: We used a meta-narrative literature review and focus group interviews with key rare disease stakeholders to better understand the perceived challenges in generating and synthesizing treatment effectiveness evidence, and to describe various research methods for mitigating these identified challenges. Data from both components of this study were synthesized narratively according to research paradigms that emerged from our data. Results: Results from our meta-narrative literature review and focus group interviews revealed three fundamental challenges in generating robust treatment effectiveness evidence for rare diseases: i) limitations in recruiting a sufficient sample size to achieve planned statistical power; ii) inability to account for clinical heterogeneity and assess treatment effects across a clinical spectrum; and iii) reliance on short-term, surrogate outcomes whose clinical relevance is often unclear. We mapped these challenges and associated solutions to three interrelated research paradigms: i) explanatory evidence generation; ii) comparative effectiveness/pragmatic evidence generation; and iii) patient-oriented evidence generation. Within each research paradigm, numerous criticisms and potential solutions have been described with respect to overcoming these challenges from a research study design perspective. Conclusions: Over time, discussions about clinical research for interventions for rare diseases have moved beyond methodological approaches to overcome challenges related to explanatory evidence generation, with increased recognition of the importance of pragmatic and patient-oriented evidence. Future directions for our work include developing a framework to expand current evidence synthesis practices to take into consideration many of the concepts discussed in this paper.
Native mortality in Canada: An epidemiological study using computerized record linkage of native administrative files with the Canada mortality database and two sources of routinely collected mortality statistics.
Creators: name: Hasselback, Paul.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Health Sciences, Public Health.

description: Natives in Canada suffer from high rates of morbidity and mortality in comparison to the Canadian population. Investigation of this inequity has been hampered by a lack of valid health statistics on native populations. This thesis assesses native mortality through a study of three potential sources of native mortality statistics using routinely collected data. Objectives were to: (1) Measure mortality indicators using a computerized record linkage of government Indian administrative records with the Canada Mortality Database. (2) Compare native mortality indicators based on the linked files, on-reserve deaths, and Medical Services Branch native client files. (3) Relate mortality amongst natives with respect to the Canadian population. (4) Determine if there is a contribution of "rural" living to native mortality. The record linkage includes deaths recorded with DIAND as occurring in 1981. The average annual mortality rate for the two other native files and comparison populations are derived from 1979-1983 records. (Abstract shortened by UMI.)
Trinkwasser wird bleifrei
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2013
Subjects: subject: Trinkwasser
subject: Blei
subject: Trinkwasserqualität
subject: Hausinstallation
subject: Bleibelastung
subject: Trinkwasser Wassergüte
subject: Trinkwasser-Hausinstallation
subject: Trinkwasserleitung
subject: Gesundheit
subject: Wasser
subject: Health
subject: Water

description: Blei im Trinkwasser gefährdet die Gesundheit. Dieses Faltblatt erläutert warum und erklärt, wie man Bleirohre erkennt und wie ein Austausch von Trinkwasserrrohren vonstattengeht.
title: Traumatismos del espacio pleural en el paciente politraumatizado. Frecuencia. Lesiones asociadas e implicación en el pronóstico del paciente.
Creators: name: Villar Cánovas, Amparo
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Trauma
subject: CT
subject: Thorax

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
Revisar lostraumatismos del espacio pleural (txEP) diagnosticados en nuestro servicio,
en el contexto del paciente politraumatizado,
durante los últimos dos años. Describir su frecuencia. Describir la asociación a otras lesiones tanto torácicas...
In search of compact massive spheroids in the local universe
Creators: name: Hon, Suei-Hei (Dexter)
Publisher: name: Swinburne
Year: 2024

description: This work investigates the possible evolutionary path taken by a special class of galaxy, i.e. the red nuggets, galaxies that are simultaneously compact, massive, and quiescent (no star formation). These galaxies were abundant ~10Gyr ago but are now extinct and have potentially been transformed structurally into other galaxy types in the local Universe. We found that some of these galaxies have gone through a rotational disc regrowth to become what we now see as lenticular or early-type galaxies. The result of this thesis solidifies the importance of disc formation as an integral part of the process of galaxy evolution.
title: Manejo de pacientes embarazadas en estudios con radiaciones ionizantes. Consentimiento informado.
Creators: name: Fernández Quintero, Rosa Mª
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Foetus
subject: Biological effects
subject: Radiation effects
subject: Medico-legal issues
subject: Radioprotection / Radiation dose
subject: Obstetrics (Pregnancy / birth / postnatal period)

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
Presentar nuestros modelos de consentimiento informado (CI) para gestantes sometidas a estudios de imagen con radiación ionizante. Exponer nuestra experiencia referida a situaciones clínicas concretas en el empleo de los mismos. Dar a conocer la...
Transformative Learning in Girl Guides of Canada : A Case Study
Creators: name: Walley, Chelsea Alyssa Anne
Publisher: name: The University of British Columbia
Year: 2025

description: Transformative Learning has been established as a desirable goal in education, with most research focusing on adult learners in post-secondary settings. However, significantly less research has been done to examine the implementation of transformative learning in non-formal education or with youth learners. As one of the largest non-formal educational organizations in Canada, Girl Guides of Canada (GGC) is the focus of this case study. Five main components of transformative learning were identified from the literature and used as the framework for understanding the extent to which GGC enables and/or constrains the implementation of transformative learning programs for its girl members. This qualitative case study uses a combination of surveys and interviews with Unit Guiders, program and organizational documents from GGC, and researcher journal reflections. The research found evidence of all five components of transformative learning in GGC, but the age of learners can be a complicating factor. The flexible and responsive nature of the GGC program was perceived by Unit Guiders as central to supporting transformative learning, particularly for youth. Four additional components that enabled transformative learning were also identified: setting expectations; just having fun; doing hard things; and personal and family associations. Providing data on how youth learners impact the way the key components of transformative learning can be implemented can offer useful guidance for educators in both non-formal and formal education. When seeking to facilitate transformative learning for young learners, the lessons learned from GGC can offer valuable suggestions for improving teaching practices.
The 2dF galaxy redshift survey: Clustering properties of radio galaxies
Creators: name: Magliocchetti, Manuela
name: Maddox, Steve J.
name: Hawkins, Ed
name: Peacock, John A.
name: Bland-Hawthorn, Joss
name: Bridges, Terry
name: Cannon, Russell
name: Cole, Shaun
name: Colless, Matthew
name: Collins, Chris
name: Couch, Warrick
name: Dalton, Gavin
name: De Propris, Roberto
name: Driver, Simon P.
name: Efstathiou, George
name: Ellis, Richard S.
name: Frenk, Carlos S.
name: Glazebrook, Karl
name: Jackson, Carole A.
name: Jones, Bryn
name: Lahav, Ofer
name: Lewis, Ian
name: Lumsden, Stuart
name: Norberg, Peder
name: Peterson, Bruce A.
name: Sutherland, Will
name: Taylor, Keith
Publisher: name: Swinburne
Year: 2024

description: The clustering properties of local, S1.4 GHz ≥ 1 mJy, radio sources are investigated for a sample of 820 objects drawn from the joint use of the Faint Images of the Radio Sky at 20 cm (FIRST) and 2dF Galaxy Redshift surveys. To this aim, we present 271 new bJ ≤ 19.45 spectroscopic counterparts of FIRST radio sources to be added to those already introduced in our previous paper. The two-point correlation function for the local radio population is found to be entirely consistent with estimates obtained for the whole sample of 2dFGRS galaxies. From measurements of the redshift-space correlation function Θ(s) we derive a redshift-space clustering length s0 = 10.7-0.7+0.8 Mpc, while from the projected correlation function ζ (rT) we estimate the parameters of the real-space correlation function ζ (r) = (r/r0) -γ, r0 = 6.7-1.10.9 Mpc and γ = 1.6 ± 0.1, where h = 0.7 is assumed. Different results are instead obtained if we only consider sources that present signatures of active galactic nucleus (AGN) activity in their spectra. These objects are shown to be very strongly correlated, with r0 = 10.9-1.2+10 Mpc and γ = 2 ± 0.1, a steeper slope than has been claimed in other recent works. No difference is found in the clustering properties of radio-AGNs of different radio luminosity. Comparisons with models for ζ (r) show that AGN-fuelled sources reside in dark matter haloes more massive than ∼1013.4 M⊙, higher than the corresponding figure for radio-quiet quasi-stellar objects. This value can be converted into a minimum black hole mass associated with radio-loud, AGN-fuelled objects of M BHmin ∼ 109 M⊙. The above results then suggest - at least for relatively faint radio objects - the existence of a threshold black hole mass associated with the onset of significant radio activity such as that of radio-loud AGNs; however, once the activity is triggered, there appears to be no evidence for a connection between black hole mass and level of radio output.
title: Variantes anatómicas de la vena cava inferior: consideraciones prequirúrgicas
Creators: name: Alfonso Cerdan, Sheila
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Congenital
subject: Normal variants
subject: Contrast agent-intravenous
subject: CT
subject: Vascular
subject: Anatomy
subject: Abdomen

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
- Revisión de las variantes anatómicas de la vena cava inferior (VCI) así como de su embriología. - Destacar los hallazgos relevantes en el TC de las variantes anatómicas más importantes y frecuentes que deben ser consideradas previamente a...
title: Vocabulary for the Registration and Description of Research Data Repositories
Creators: name: Vierkant, Paul
name: Spier, Shaked
name: Ruecknagel, Jessika
name: Gundlach, Jens
name: Kindling, Maxi
name: Pampel, Heinz
name: Manova, Stefka
name: Goebelbecker, Hans-Juergen
name: Klump, Jens
name: Bertelmann, Roland
name: Schirmbacher, Peter
name: Scholze, Frank
Publisher: name: re3data.org
Year: 2012
Subjects: research data
data repositories

description: re3data.org
Ethnobotany and ethnopharmacology of Q'eqchi' Maya medicinal plants from southern Belize used for ethnopsychiatric and neurological purposes
Creators: name: Bourbonnais-Spear, Natalie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Health Sciences, Pharmacy.
subject: Psychology, General.

description: This study investigated plant use by Q'eqchi' Maya healers (Southern Belize) in the context of ethno-psychiatric and neurological conditions. The healers recognize eight of these disorders, which they treat with 82 identified plant species. Moreover, the Piperaceae family is the plant family most selected by the healers for these purposes. In a second section, the etiological basis of susto, a folk illness known throughout Latin America, was investigated. Some plants used by most of the healers showed anxiolytic and/or fear suppression activity. In addition, rituals surrounding the treatment process may have calming effects, and many plants used for susto are often used to treat mental/neurological disorders as well. This strengthens the basis for the inclusion of psychological/neurological factors in susto. A third section gives insights into the domestication and conservation of key medicinal species, indicating that harvesting practices are sustainable in the current context.
title: Toxikologische Basisdaten und Textentwürfe für die Ableitung eines EU-LCI-Wertes für 2,2,4-Trimethyl-1,3-pentandiol monoisobutyrat, 2,2,4-Trimethylpentandiol diisobutyrat, 2-Methyl-1-propanol, 2-Phenoxyethanol, Isopropylbenzol
title: Toxikologische Basisdaten und Textentwürfe für die Ableitung eines EU-LCI-Wertes für 2,2,4-Trimethyl-1,3-pentandiol monoisobutyrat, 2,2,4-Trimethylpentandiol diisobutyrat, 2-Methyl-1-propanol, 2-Phenoxyethanol, Isopropylbenzol
titleType: AlternativeTitle
Creators: name: Wibbertmann, Axel
name: Wahnschaffe, Ulrich
name: Wiedemeier, Petra
Publisher: name: Umweltbundesamt
Year: 2017
Subjects: subject: Stoffbewertung
subject: LCI-Werte
subject: Bauprodukte
subject: Internationale Harmonisierung
subject: Stoffbewertungen
subject: Chemikalien

description: In diesem Projekt wurden für fünf Stoffe toxikologische Daten zusammengestellt und bewertet mit anschließender Ableitung einer Lowest Concentration of Interest (LCI). LCI-Werte ermöglichen eine europaweit einheitliche Bewertung gesundheitlicher Risiken durch Schadstoffe aus Baumaterialien. Die Ableitung dieser Werte erfolgte gemäß ECA Report 29 (ECA-IAQ, 2013).
Quelle: Forschungsbericht
description: In this project for five substances toxicological data were collected and evaluated with subsequent derivation of a Lowest Concentration of Interest (LCI). In Europe, these LCI values can be used for an assessment of health risks from emissions of building materials. The derivation of these values was performed according to ECA Report 29 (ECA-IAQ, 2013).
Quelle: Forschungsbericht
description: Im Rahmen dieses Forschungsvorhabens wurden 5 Stoffdossiers für die folgenden Stoffe erstellt: 2-Phenoxyethanol (CAS Nr. 122-99-6), 2-Methyl-1-propanol (CAS 78-83-1), 2,2,4-Trimethyl-1,3-pentandiol monoisobutyrat (CAS Nr. 25265-77-4), 2,2,4-Trimethylpentandiol diisobutyrat (CAS Nr. 6846-50-0) und Isopropylbenzol (CAS Nr. 98-82-8). Für diese Stoffe wurden die toxikologischen Basisdaten recherchiert, zusammengestellt und, anhand der Daten, EU-LCI Werte vorgeschlagen. Die EU-LCI Werte bilden die Bemessungsgrundlage für die gesundheitliche Wirkung von Emissionen aus Bauprodukten und sollten eine europaweite Vereinheitlichung der gesundheitlichen Bewertung von Bauproduktemissionen ermöglichen. Die endgültigen EU-LCI Werte werden allerdings von der EU-LCI Arbeitsgruppe, eine Expertengruppe mit Fachleuten aus zehn europäischen Ländern, festgelegt. Diese Arbeitsgruppe entwickelt derzeit eine harmonisierte europäische Liste mit Stoffen und den dazugehörigen Emissionsgrenzen (EU-LCI Werte). Die im Rahmen dieses Projektes erarbeiteten Stoffdossiers unterstützen und beschleunigen diesen Prozess.
Artificial Intelligence Driven Non-Linear Narrative: An Extended Reality Application for Management Training
Creators: name: Gironacci, Irene M.
Publisher: name: Swinburne
Year: 2024

description: Existing XR simulations use pre-configured scenarios in which the trainee always experiences the same training, without any variation or personalization to suit the needs or background and behaviour of the trainee. This research intends to contribute to the existing knowledge in the field of AI-driven narrative exploring how training simulators could evolve towards an interactive and dynamic narrative experience, by integrating Artificial Intelligence in an Extended Reality training simulator. In particular, the simulator uses a Content-Based recommender system to recommend training scenarios to the user. Although customization can be achieved in many ways, this project focuses on in-game input data: user interaction with virtual objects, decisions made by the user, and metadata associated with the training scenario.
Pre-Interventional Kynurenine Predicts Medium-Term Outcome after Contrast Media Exposure Due to Coronary Angiography
Creators: name: Reichetzeder, Christoph
name: Heunisch, Fabian
name: Von Einem, Gina
name: Tsuprykov, Oleg
name: Kellner, Karl-Heinz
name: Dschietzig, Thomas
name: Kretschmer, Axel
name: Hocher, Berthold
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Contrast induced acute kidney injury
subject: Coronary angiography
subject: Major adverse kidney event
subject: Kynurenine
subject: Preinterventional biomarker
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background/Aims: Contrast induced acute kidney injury (CI-AKI) remains a serious complication of contrast media enhanced procedures like coronary angiography. There is still a lack of established biomarkers that help to identify patients at high risk for short and long-term complications. The aim of the current study was to evaluate plasma kynurenine as a predictive biomarker for CI-AKI and long-term complications, measured by the combined endpoint "major adverse kidney events" (MAKE) up to 120 days after CM application. Methods: In this prospective cohort study 245 patients undergoing coronary angiography were analyzed. Blood samples were obtained at baseline, 24h and 48h after contrast media (CM) application to diagnose CI-AKI. Patients were followed for 120 days for adverse clinical events including death, the need for dialysis, and a doubling of plasma creatinine. Occurrence of any of these events was summarized in the combined endpoint MAKE. Results: Preinterventional plasma kynurenine was not associated with CI-AKI. Patients who later developed MAKE displayed significantly increased preinterventional plasma kynurenine levels (p<0.0001). ROC analysis revealed that preinterventional kynurenine is highly predictive for MAKE (AUC=0.838; p<0.0001). The optimal cutoff was found at ≥3.5 µmol/L Using this cutoff, the Kaplan-Meier estimator demonstrated that concentrations of plasma kynurenine ≥3.5 µmol/L were significantly associated with a higher prevalence of MAKE until follow up (p<0.0001). This association remained significant in multivariate Cox regression models adjusted for relevant factors of long-term renal outcome. Conclusion: Preinterventional plasma kynurenine might serve as a highly predictive biomarker for MAKE up to 120 days after coronary angiography.
Increased richness and diversity of the vaginal microbiota and spontaneous preterm birth
Creators: name: Freitas, Aline C.
name: Bocking, Alan
name: Hill, Janet E.
name: Money, Deborah M.
Publisher: name: BioMed Central
Year: 2018

description: Background: The bacterial community present in the female lower genital tract plays an important role in maternal and neonatal health. Imbalances in this microbiota have been associated with negative reproductive outcomes, such as spontaneous preterm birth (sPTB), but the mechanisms underlying the association between a disturbed microbiota and sPTB remain poorly understood. An intrauterine infection ascending from the vagina is thought to be an important contributor to the onset of preterm labour. Our objective was to characterize the vaginal microbiota of pregnant women who had sPTB (n = 46) and compare to those of pregnant women who delivered at term (n = 170). Vaginal swabs were collected from women at 11–16 weeks of gestational age. Microbiota profiles were created by PCR amplification and pyrosequencing of the cpn60 universal target region. Results: Profiles clustered into seven community state types: I (Lactobacillus crispatus dominated), II (Lactobacillus gasseri dominated), III (Lactobacillus iners dominated), IVA (Gardnerella vaginalis subgroup B or mix of species), IVC (G. vaginalis subgroup A dominated), IVD (G. vaginalis subgroup C dominated) and V (Lactobacillus jensenii dominated). The microbiota of women who experienced preterm birth (< 37 weeks gestation) had higher richness and diversity and higher Mollicutes prevalence when compared to those of women who delivered at term. The two groups did not cluster according to CST, likely because CST assignment is driven in most cases by the dominance of one particular species, overwhelming the contributions of more rare taxa. In conclusion, we did not identify a specific microbial community structure that predicts sPTB, but differences in microbiota richness, diversity and Mollicutes prevalence were observed between groups. Conclusions: Although a causal relationship remains to be determined, our results confirm previous reports of an association between Mollicutes and sPTB and further suggest that a more diverse microbiome may be important in the pathogenesis of some cases.