cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of TNFAIP3 mutation may be associated with favorable overall survival for patients with T-cell lymphoma
Creators: name: Chen, Cunte
name: Chen, Zheng
name: Huang, Ling
name: Zhou, Lingling
name: Zhu, Lihua
name: Liu, Sichu
name: Luo, Gengxin
name: Li, Wenyu
name: Zeng, Chengwu
name: Li, Yangqiu
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1: Table S1. PCR primers for TNFAIP3.
Spaces of expertise and geographies of ethics : health worker recruitment and migration from the Philippines to Canada
Creators: name: Santiago, Mark Lawrence
Publisher: name: University of British Columbia
Year: 2015

description: Spaces of Expertise and Geographies of Ethics: Health Worker Recruitment and Migration from the Philippines to Canada is my contribution to the contemporary academic and policy interest on the issue of international recruitment and migration of health workers. Through the discipline of human geography and using global ethnographic methodology, my thesis fulfils four overlapping aims and objectives: (1) I explain the role of state institutions in the recruitment and migration of registered nurses from a major sending country context, the Philippines; (2) I illustrate how private recruitment agencies’ strategic partnership with Philippine state institutions facilitate the migration of Philippine nurses to Canada and other migrant workers globally; (3) I describe the work of Canadian state institutions that sustain and support the current dependence of a receiving country like Canada on immigrant health workers through one province’s “ethical recruitment” drive and the daily work of one provincial recruitment firm and finally; (4) I analyse how bilateral agreements, international instruments and ethical institutional design facilitate international health worker recruitment and migration. Through historically informed, ethically orientated and empirically grounded socio-cultural and political geographic analyses, I narrate stories of local, transnational and global policies circulating and flowing through the knowledge, action and expertise of individuals across multiple institutions and state border that affect and frame the issue of health worker recruitment and migration.
Unexpected weak spatial variation of local density of sates induced by individual Co impurity atoms in Na(Fe{1-x}Cox)As as revealed by scanning tunneling spectroscopy
Creators: name: Yang, Huan
name: Wang, Zhenyu
name: Fang, Delong
name: Li, Sheng
name: Kariyado, Toshikaze
name: Chen, Genfu
name: Ogata, Masao
name: Das, Tanmoy
name: Balatsky, A. V.
name: Wen, Hai-Hu
Publisher: name: arXiv
Year: 2012
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We use spatially resolved scanning tunneling spectroscopy in Na(Fe{1-x}Cox)As to investigate the impurity effect induced by Co dopants. The Co impurities are successfully identified, and the spatial distributions of local density of state at different energies around these impurities are investigated. It is found that the spectrum shows negligible spatial variation at different positions near the Co impurity, although there is a continuum of the in-gap states which lifts the zero-bias conductance to a finite value. Our results put constraints on the S+- and S++ models and sharpen the debate on the role of scattering potentials induced by the Co dopants.
description: 8 pages, 10 figures
Some operators that preserve the locality of a pseudovariety of semigroups
Creators: name: Costa, Alfredo
name: Escada, Ana
Publisher: name: arXiv
Year: 2011
Subjects: subject: Group Theory (math.GR)
subject: FOS: Mathematics
subject: 20M07, 20M35

description: It is shown that if V is a local monoidal pseudovariety of semigroups, then K(m)V, D(m)V and LI(m)V are local. Other operators of the form Z(m)(_) are considered. In the process, results about the interplay between operators Z(m)(_) and (_)*D_k are obtained.
description: To appear in International Journal of Algebra and Computation
Additional file 1 of Insulin-like growth factor-2 does not improve behavioral deficits in mouse and rat models of Angelman Syndrome
Creators: name: Berg, Elizabeth L.
name: Petkova, Stela P.
name: Born, Heather A.
name: Adhikari, Anna
name: Anderson, Anne E.
name: Silverman, Jill L.
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Pharmacology

description: Additional file 1. Supplementary information.
A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia
Creators: name: Shah, Sohela
name: Schrader, Kasmintan A.
name: Waanders, Esmé
name: Timms, Andrew E.
name: Vijai, Joseph
name: Miething, Cornelius
name: Wechsler, Jeremy
name: Yang, Jun
name: Hayes, James
name: Klein, Robert J.
name: Zhang, Jinghui
name: Wei, Lei
name: Wu, Gang
name: Rusch, Michael
name: Nagahawatte, Panduka
name: Ma, Jing
name: Chen, Shann-Ching
name: Song, Guangchun
name: Cheng, Jinjun
name: Meyers, Paul
name: Bhojwani, Deepa
name: Jhanwar, Suresh
name: Maslak, Peter
name: Fleisher, Martin
name: Littman, Jason
name: Offit, Lily
name: Rau-Murthy, Rohini
name: Fleischut, Megan Harlan
name: Corines, Marina
name: Murali, Rajmohan
name: Gao, Xiaoni
name: Manschreck, Christopher
name: Kitzing, Thomas
name: Vundavalli, Murty V.
name: Raimondi, Susana C.
name: Kuiper, Roland P.
name: Simons, Annet
name: Schiffman, Joshua D.
name: Onel, Kenan
name: Plon, Sharon E.
name: Wheeler, David A.
name: Ritter, Deborah
name: Ziegler, David S.
name: Tucker, Kathy
name: Sutton, Rosemary
name: Chenevix-Trench, Georgia
name: Li, Jun
name: Huntsman, David G.
name: Hansford, Samantha
name: Senz, Janine
name: Walsh, Tom
name: Lee, Ming
name: Hahn, Christopher N.
name: Roberts, Kathryn G.
name: King, Mary-Claire
name: Lo, Sarah M.
name: Levine, Ross L.
name: Viale, Agnes
name: Socci, Nicholas D.
name: Nathanson, Katherine L.
name: Scott, Hamish S.
name: Daly, Mark
name: Lipkin, Steven M.
name: Lowe, Scott W.
name: Downing, James R.
name: Altshuler, David
name: Sandlund, John T.
name: Horwitz, Marshall S.
name: Mullighan, Charles G.
name: Offit, Kenneth
Publisher: name: Columbia University
Year: 2013
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Human chromosome abnormalities--Diagnosis
subject: Leukemia

description: Somatic alterations of the lymphoid transcription factor gene PAX5 (also known as BSAP) are a hallmark of B cell precursor acute lymphoblastic leukemia (B-ALL)1–3, but inherited mutations of PAX5 have not previously been described. Here we report a new heterozygous germline variant, c.547G>A (p.Gly183Ser), affecting the octapeptide domain of PAX5 that was found to segregate with disease in two unrelated kindreds with autosomal dominant B-ALL. Leukemic cells from all affected individuals in both families exhibited 9p deletion, with loss of heterozygosity and retention of the mutant PAX5 allele at 9p13. Two additional sporadic ALL cases with 9p loss harbored somatic PAX5 substitutions affecting Gly183. Functional and gene expression analysis of the PAX5 mutation demonstrated that it had significantly reduced transcriptional activity. These data extend the role of PAX5 alterations in the pathogenesis of pre-B cell ALL and implicate PAX5 in a new syndrome of susceptibility to pre-B cell neoplasia.
Overtopping Wave Energy Converters: general aspects and stage of development
Creators: name: Bevilacqua, Giovanna
name: Zanuttigh, Barbara
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2011
Subjects: ICAR/01 Idraulica

description: Wave power is the transport of energy by ocean surface waves, and the capture of that energy to do useful work, for example for electricity generation, water desalination, or the pumping of water (into reservoirs). For these and many other reasons, technologies to exploit wave resource are increasingly developing, especially in the recent years, and the wave power could potentially represent a very practical solution.
Devices able to generate electricity exploiting the energy of the waves are commonly called Wave Energy Converter (WEC). At the moment exist a variety of technologies to capture the energy from waves; one of these is the one of the Overtopping Converters. An Overtopping device captures sea water of incident waves in a reservoir above the sea level, then releases the water back to sea through turbines connected to a generator
Nonlinear Modeling of Si/SiGe HBT Using ANN
Creators: name: Taher, H.
name: Schreurs, D.
name: Vestiel, E.
name: Gillon, R.
name: Nauwelaers, B.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2004
Subjects: ING-INF/01 Elettronica

description: We present a large signal model for Si/SiGe
HBTs using an Artificial Neural Network (ANN). The ANN
is used to model the DC non-linearities of the intrinsic device. In this way, physical phenomena such as nonideal
leakage currents and the Kirk effect can be modeled without
time-consuming extraction. Capacitive nonlinearities are
modeled by the well-known relationship between the
capacitance and the junction voltage, ignoring the diffusion
capacitance. By comparing ANN model results to
measurements, we show that a good agreement for DC and
nonlinear characteristics is obtained.
Funktionelle Charakterisierung des Arabidopsis MAP-Kinase 6-Substrates, AtERF104, in Hinblick auf die basale Resistenz
Creators: name: Bethke, Gerit
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2009
Subjects: subject: Online-Publikation
subject: Hochschulschrift
subject: 571.963742364
subject: 570

description: MAPK-Kaskaden spielen in allen Eukaryoten eine entscheidende Rolle bei der Intergration extrazellulärer Stimuli in zelluläre Antworten. In Arabidopsis thaliana werden die MAPKinasen AtMPK3, AtMPK4 und AtMPK6 durch den PAMP (Pathogen-Associated Molecular Pattern) flg22 aktiviert. Die vorliegende Arbeit beschreibt die Identifikation des Transkriptionsfaktors AtERF104 als neues in vivo-Substrat von AtMPK6. Die Phosphorylierung durch AtMPK6 erhöht dabei die Proteinstabilität von AtERF104. AtMPK6 und AtERF104 bilden einen Komplex im Zellkern, der nach Elicitierung mit dem PAMP flg22 aufgelöst wird. Für die Auflösung der Interaktion von AtERF104 und AtMPK6 sind die Kinaseaktivität von AtMPK6 und die Phosphorylierbarkeit von AtERF104 entscheidend. Dabei liegt die Aktivierung von AtMPK6 im Signalweg oberhalb der Ethylenbiosynthese. Weiterhin konnte gezeigt werden, daß obwohl die biochemische Aktivierung von AtMPK6 unabhängig von der Ethylensignaltransduktion ist, für die Auflösung der AtMPK6-AtERF104-Interaktion eine funktionierende Ethylensignalkaskade entscheidend ist. AtERF104 kann spezifisch GCC-Element-enthaltende Promotoren binden und die Genexpression nachgestellter Gene induzieren. Als direktes Zielgen von AtERF104 wurde AtPDF1.2 identifiziert. Die Resistenz gegen das nichtadaptierte Pathogen Pseudomonas syringae pv. phaseolicola war sowohl in ERF104-Überexpressionslinien als auch in ERF104-RNAi- bzw. knockout-Linien reduziert. AtERF104 spielt also eine Rolle in der basalen Resistenz. Auch die verstärkte flg22-abhängige Inhibierung des Wurzelwachstums in AtERF104OE und erf104 unterstreicht die Bedeutung von AtERF104 in den Signalwegen nach PAMP-Erkennung.
PCDH10, a novel p53 transcriptional target in regulating cell migration
Creators: name: Shi, Dingding
name: Vundavalli, Murty V.
name: Gu, Wei
Publisher: name: Columbia University
Year: 2015
Subjects: Antioncogenes
p53 antioncogene
Cell cycle--Regulation
Aging
Apoptosis
Cell migration

description: Cell cycle arrest, senescence and apoptosis are commonly regarded as the major tumor suppression mechanisms of p53. However, accumulating evidence indicates that loss of these canonical functions is not sufficient for tumor formation, highlighting the complexity of p53-mediated tumor suppression. PCDH10 belongs to a proto cadherin protein family and is a potential tumor suppressor protein as the dysregulation of PCDH10 gene frequently existed in multiple human tumors. Here, we found that PCDH10 is a transcriptional target of p53 and that the levels of PCDH10 expression can be induced by wild type p53 but not mutant p53 in a number of human cancer cell lines. Moreover, we identified a p53 consensus binding site located in the PCDH10 promoter region that is responsive to p53 regulation. Although upregulation of PCDH10 has no obvious effect on growth arrest or apoptosis in human cells, PCDH10 exhibits inhibitory roles in cancer cell motility and cell migration. These results suggest an important role of p53 in regulating tumor cell migration through activating PCDH10 expression and support the notion that non-canonical activities of p53 may contribute to its tumor suppressor function in vivo.
A probabilistic approach to interior regularity of fully nonlinear degenerate elliptic equations in smooth domains
Creators: name: Zhou, Wei
Publisher: name: arXiv
Year: 2011
Subjects: subject: Probability (math.PR)
subject: Analysis of PDEs (math.AP)
subject: Optimization and Control (math.OC)
subject: FOS: Mathematics
subject: 60H30, 60J60, 35J60, 35J70, 35B65, 93E20, 49L20

description: We consider the value function of a stochastic optimal control of degenerate diffusion processes in a domain $D$. We study the smoothness of the value function, under the assumption of the non-degeneracy of the diffusion term along the normal to the boundary and an interior condition weaker than the non-degeneracy of the diffusion term. When the diffusion term, drift term, discount factor, running payoff and terminal payoff are all in the class of $C^{1,1}(\bar D)$, the value function turns out to be the unique solution in the class of $C_{loc}^{1,1}(D)\cap C^{0,1}(\bar D)$ to the associated degenerate Bellman equation with Dirichlet boundary data. Our approach is probabilistic.
description: Accepted. 31 pages
A High Performance 2.4GHz Linear Power Amplifier in
Enhancement-mode GaAs pHEMT Technology
Creators: name: Chow, Yut-Hoong
name: Chong, Thomas
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2004
Subjects: ING-INF/01 Elettronica

description: This paper describes the design and realization of a high performance linear power amplifier in the 2.4GHz band for the IEEE 802.11b/g WLAN (Wireless Local Area Network) and ISM (Industrial Scientific and Medical) applications using a proprietary 0.5um enhancement-mode Pseudomorphic High-Electron-Mobility Transistor (e-pHEMT) technology. 
The amplifier exhibits a linear power output of 18.5dBm at 5%Error Vector magnitude (EVM) and efficiency of 30% at 2.45GHz at 3.3V supply in a chip-on-board (COB) module. The design also includes an integrated power detector.
Additional file 1 of Development of genus-specific universal primers for the detection of flaviviruses
Creators: name: Daidoji, Tomo
name: Morales Vargas, Ronald Enrique
name: Hagiwara, Katsuro
name: Arai, Yasuha
name: Watanabe, Yohei
name: Nishioka, Keisuke
name: Murakoshi, Fumi
name: Garan, Kotaro
name: Sadakane, Hiroki
name: Nakaya, Takaaki
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: Ecology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Additional file 1. Fig. S1: Standard curve for the quantitative-PCR assay. A standard curve of Ct values versus copy number. The standard curve was constructed by 10-fold serial dilution (8.16 × 107 to 8.16 copies) of a plasmid encoding the JEV genome. All Ct values are the mean values of quadruplicate measurements, except for the value of 8.16 copies, which is the mean value of triplicate measurements (due to the detection limit).
Untersuchungen zur Wirkung von Biotin auf humane Keratinozyten und zur Modulation der Biotinpenetration in humane Haut
Creators: name: Huschka, Christoph
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1998
Subjects: Elektronische Publikation

description: In der vorliegenden Arbeit wurde der Einfluß von Biotin auf humane kultivierte Keratinozyten untersucht. Dabei bestand das vorrangige Ziel in der Klärung des Wirkungsmechanismus bzw. der zellulären Reaktion des Keratinozyten auf verschiedene Wirkstoffkonzentrationen. Die Ergebnisse zeigten eine hohe Toleranz der Zellsystems gegenüber dem Vitamin. Sowohl die Proliferation als auch der Ablauf der Differenzierung der Keratinozyten können frei vom Einfluß des Biotins gewertet werden. Gleiches gilt für den regulative Einfluß auf die Apoptose, die durch Fettsäuren induziert wurde. Nach Überschreiten einer notwendigen Schwellkonzentration war eine steigernde Wirkung von Biotin auf die Synthese von Lipiden im Kerationzyten nachweisbar. Aufbauend auf die ermittelten epidermal wirksamen Biotinkonzentrationen schloß sich eine Studie zum Penetrationsverhalten von topisch appliziertem Biotin in humane Haut ex vivo an. Innerhalb dieser Untersuchungen lag der Schwerpunkt auf der systematischen Penetrationsbeeinflussung. Dabei galt das Interesse neben der Vehikelmodulation durch die Anwendung verschiedener kolloidaler Arzneistoffträgersysteme auch der gezielten Modulation von standardisierten Emulsionen. Nach den vorliegenden Ergebnissen eignen sich die Modulatoren Hyaluronidase und Harnstoff besonders für den effektiven Transport von Biotin in die lebenden Schichten der Haut.
description: In the present study the influence of biotin on human cultured keratinocytes was examined. The prior-ranking aim was to characterize the effect mechanism and the cellular reaction of the keratinocytes to different drug concentrations. The human epidermal cells have shown a high tolerance of the vitamin. Both the proliferation and the differentiation of the keratinocytes can be judged to be free of the influence of biotin. No regulatory influence on the apoptosis, which was induced by fatty acids, could be detected. After exceeding a necessary swelling concentration an increasing effect of biotin on the lipid synthesis in the kerationcytes was provably. Following the results from the cell culture and the known necessary effective concentration of biotin we determined the penetration behavior of topical applied biotin into human skin ex vivo. Within these examinations the main interest lay on the systematic modulation of the penetration behavior. So we compared the biotin penetration from standardized emulsions with modulated emulsions and with different types of biotin containing colloidal drug carriers too. Our results particularly recommend the use of the modulators hyaluronidase and urea for an effective enhancement of biotin into the living layers of the skin.
Cytogenetic analysis of adult T-Cell leukemia/ lymphoma: evaluation of a Caribbean cohort
Creators: name: Sun, Yi
name: Vundavalli, Murty V.
name: Leeman-Neill, Rebecca J.
name: Soderquist, Craig R.
name: Park, David C.
name: Neill, Daniel B.
name: Bhagat, Govind
name: Alobeid, Bachir
Publisher: name: Columbia University
Year: 2019
Subjects: Cytogenetics
Adult T-cell leukemia
HTLV-I infections
Leukemia
Lymphomas
Cohort analysis

description: Adult T-cell leukemia/lymphoma (ATLL) is a rare and highly aggressive type of peripheral T-cell lymphoma associated with human T-lymphotropic virus, type I (HTLV-I) infection. ATLL has a long latency and only a small percentage of HTLV-I infected individuals develop ATLL, suggesting the requirement of additional genetic events for neoplastic transformation of HTLV-I infected lymphocytes. The disease is endemic in several regions of the world, in particular, southwestern Japan and the Caribbean basin. The clinical features of Caribbean ATLL have been reported to differ from Japanese cases, includ- ing a younger age at diagnosis, higher frequency of the lymphomatous subtype, and a more aggressive clinical course [1–7]. A number of publications have described the cytogenetic profile of Japanese ATLL [8–11]; however, cytogenetic data on Caribbean ATLL are limited [5,6]. In this study, we assessed the cytogenetic alterations in a large series of Caribbean ATLL cases to investigate whether the differences in the types and frequencies of karyotype abnormalities account for the reported differ- ences in clinical presentation and outcome between Japanese and Caribbean patients.
Additional file 1 of Incidence and missed diagnosis risk of occult posterior malleolar fractures associated with the tibial shaft fractures: a systematic review
Creators: name: Wang, Zhongzheng
name: Chen, Wei
name: Zhu, Yanbin
name: Tian, Siyu
name: Zhao, Kuo
name: Guo, Jialiang
name: Hou, Zhiyong
name: Zhang, Qi
name: Zhang, Yingze
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1. PRISMA 2020 Checklist.
Anisotropic Conductive Adhesives for Millimeterwave
Flipchip Interconnections
Creators: name: Heyen, Johann
name: Jacob, Arne F.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2004
Subjects: ING-INF/01 Elettronica

description: In this paper anisotropic conductive pastes (ACP) are proposed for the 1st level interconnect of millimeter-wave multichip modules (MCM) and packages. This 1st level interconnect between components on top of the module
and the MCM is established in a flipchip approach. Here,
instead of gold based bumps ACP together with a structured
dielectric layer are used. The latter features additional chip
support and bump shaping capabilities. These flipchip arrangements are experimentally investigated and compared
to conventional gold based interconnections up to 110GHz.
Additional file 1 of Complete reversal of bilateral optic nerve infiltration from lymphoblastic leukemia using chemotherapy without adjuvant radiotherapy
Creators: name: da Costa, Douglas Rodrigues
name: Fernandes, Rodrigo Dahia
name: Susanna, Fernanda Nicolela
name: da Silva Neto, Epitácio Dias
name: Monteiro, Mario Luiz Ribeiro
Publisher: name: figshare
Year: 2021
Subjects: Medicine
Neuroscience
Pharmacology
Cancer
Hematology

description: Additional file 1. Bone marrow analysis upon diagnosis. Bone marrow analysis upon diagnosis. CD: cluster of differentiation; TdT: terminal deoxynucleotidyl transferase; PBX1: PBX Homebox 1.
Epigenetic Inactivation of TRAIL Decoy Receptors at 8p12-21.3 Commonly Deleted Region Confers Sensitivity to Apo2L/TRAIL-Cisplatin Combination Therapy in Cervical Cancer
Creators: name: Narayan, Gopeshwar
name: Xie, Dongxu
name: Ishdorj, Ganchimeg
name: Scotto, Luigi
name: Mansukhani, Mahesh M.
name: Pothuri, Bhavana
name: Wright, Jason D.
name: Kaufmann, Andreas
name: Schneider, Achim
name: Arias-Pulido, Hugo
name: Vundavalli, Murty V.
Publisher: name: Columbia University
Year: 2016
Subjects: subject: Epigenetics
subject: Genetics
subject: FOS: Biological sciences
subject: Cervix uteri--Cancer
subject: Cervix uteri--Cancer--Treatment
subject: Carcinogenesis

description: Multiple chromosomal regions are affected by deletions in cervical cancer (CC) genomes, but their consequence and target gene involvement remains unknown. Our single nucleotide polymorphism (SNP) array identified 8p copy number losses localized to an 8.4 Mb minimal deleted region (MDR) in 36% of CC. The 8p MDR was associated with tumor size, treat- ment outcome, and with multiple HPV infections. Genetic, epigenetic, and expression analyses of candidate genes at MDR identified promoter hypermethylation and/or inactivation of decoy receptors TNFRSF10C and TNFRSF10D in the majority of CC patients. TNFRSF10C methylation was also detected in precancerous lesions suggesting that this change is an early event in cervical tumorigenesis. We further demonstrate here that CC cell lines exhibiting downregulated expression of TNFRSF10C and/or TNFRSF10D effectively respond to TRAIL-induced apoptosis and this affect was synergistic in combi- nation with DNA damaging chemotherapeutic drugs. We show that the CC cell lines harboring epigenetic inactivation of TRAIL decoy receptors effectively activate downstream caspases suggesting a critical role of inactivation of these genes in efficient execution of extrinsic apoptotic pathway and therapy response. Therefore, these findings shed new light on the role of genetic/epigenetic defects in TRAIL decoy receptor genes in the pathogenesis of CC and provide an opportunity to explore strategies to test decoy receptor gene inactivation as a biomarker of response to Apo2L/TRAIL-combination therapy.
A 1-Watt Ku-band Power Amplifier MMIC using
Cost-effective Organic SMD Package
Creators: name: Bessemoulin, A.
name: Parisot, M.
name: Quentin, P.
name: Saboureau, C.
name: Van Heijningen, M.
name: Priday, J.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2004
Subjects: ING-INF/01 Elettronica

description: This paper presents the design and performance of a compact 1-Watt Ku-band power amplifier MMIC implemented in a novel microwave organic power package, compatible with SMD assembly lines. Due to the use of simple materials, like RO4003 substrate and copper, it allows significant cost reduction for RF module assembly.
The packaged amplifier MMIC demonstrates as well, very
high-gain, as high as 32 dB at Ku-band, under very stable
conditions, and more than 1.25-Watt continuous-wave
output power (>31 dBm).
Non-Linear Modeling of the Kink Effect in Deep
Sub-micron SOI MOSFET
Creators: name: Siligaris, Alexandre
name: Dambrine, G.
name: Danneville, F.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2004
Subjects: ING-INF/01 Elettronica

description: Starting from an empirical non-linear model developed for deep sub-micron channel MOSFETs, we present a new model for floating body SOI MOSFETs. It
introduces a new non-linear current model for the kink effect,
which takes into account of the related frequency dispersion.
The model reproduces very well the AC experimental properties related to the kink effect in floating body devices.
As an application, it is used in the framework of large signal
simulations to study the impact of the kink effect on the third
order intermodulation point.
Index Terms — Non linear RF modeling, MOS SOI
transistors, low frequency effects, kink effect,
intermodulation.
Distributed Amplifiers for Transmitter and Receiver
of a 40 Gbit/s DPSK Optical Transmission System
Creators: name: Milivojevic, B.
name: Hoffmann, S.
name: Thiede, A.
name: Noé, R.
name: Leblanc, R.
name: Wroblewsk, B.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2004
Subjects: ING-INF/01 Elettronica

description: For a 40 Gbit/s DPSK optical transmission system, two circuits are reported. The first circuit is a high frequency, high power modulator driver based on a twin traveling wave amplifier (combiner) with an active power divider circuit and measured output voltages greater than 7 Vpp. A second circuit consisting of a differential preamplifier and TWA main stages is presented with concept and simulation results.
Singularity in self-energy and composite fermion excitations of interacting electrons
Creators: name: Zhu, Lijun
name: Zhu, Jian-Xin
Publisher: name: arXiv
Year: 2011
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We propose that a composite fermion operator $f_{iσ}(2n_{i{\bar σ}}-1)$ could have coherent excitations, where $f_{iσ}$ is the fermion operator for interacting electrons and $n_{i{\bar σ}}$ is the number operator of the opposite spin. In the two-impurity Anderson model, it is found that the excitation of this composite fermion has a pseudogap in the Kondo regime, and has a finite spectral weight in the regime where the excitation of the regular fermion $f_{iσ}$ has a pseudogap. In the latter regime, the self-energy of $f_{iσ}$ is found to be singular near Fermi energy. We argue that this composite fermion could develop a Fermi surface with Fermi liquid behaviors but "hidden" from charge excitations in lattice generalizations. We further illustrate that this type of excitations is essential in addressing the pseudogap state and unconventional superconductivity.
description: 10 pages, 6 figures
Improvement in ACLR Asymmetry forW-CDMA
InGaP/GaAs HBT Power Amplifier
Creators: name: Kimura, Koichi
name: Seki, Masato
name: Matsumura, Nobuhisa
name: Honjo, Kazuhiko
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2004
Subjects: ING-INF/01 Elettronica

description: Asymmetry in Adjacent Channel Leakage
power Ratio (ACLR) has been often observed in high power
amplifiers for digital wireless communication systems such
as W-CDMA. This paper describes a method for reducing
the asymmetry by controlling bias circuit impedance at sub
harmonics. By shortening both at 4MHz and 8MHz at the
bias circuits, an 8.37-dB ACLR asymmetry could be
suppressed to a 5.05-dB ACLR asymmetry, where a 10.5-dB
3rd order Inter Modulation Distortion (IMD3) asymmetry
could also be successfully improved to a 1.8-dB IMD3
asymmetry.
PCDH10 Promoter Hypermethylation is Frequent in most Histologic Subtypes of Mature Lymphoid Malignancies and Occurs Early in Lymphomagenesis
Creators: name: Narayan, Gopeshwar
name: Xie, Dongxu
name: Freddy, Allen J.
name: Ishdorj, Ganchimeg
name: Do, Catherine
name: Satwani, Prakash
name: Liyanage, Hema
name: Clark, Lorraine N.
name: Kisselev, Sergey
name: Nandula, Subhadra
name: Scotto, Luigi
name: Alobeid, Bachir
name: Savage, David G.
name: Tycko, Benjamin
name: O’Connor, Owen Anthony
name: Bhagat, Govind
name: Vundavalli, Murty V.
Publisher: name: Columbia University
Year: 2013
Subjects: Lymphomas
Carcinogenesis
Promoters (Genetics)
Methylation
Epigenetics

description: PCDH10 is epigenetically inactivated in multiple tumor types; however, studies in mature lymphoid malignancies are limited. Here, we have investigated the presence of promoter hypermethylation of the PCDH10 gene in a large cohort of well-characterized subsets of lymphomas. PCDH10 promoter hypermethylation was identified by methylation-specific PCR in 57 to 100% of both primary B- and T-cell lymphoma specimens and cell lines. These findings were further validated by Sequenom Mass-array analysis. Promoter hypermethylation was also identified in 28.6% cases of reactive follicular hyperpla- sia, more commonly occurring in states of immune deregulation and associated with rare presence of clonal karyotypic aberrations, suggesting that PCDH10 methylation occurs early in lymphomagenesis. PCDH10 expression was down regu- lated via promoter hypermethylation in T- and B-cell lymphoma cell lines. The transcriptional down-regulation resulting from PCDH10 methylation could be restored by pharmacologic inhibition of DNA methyltransferases in cell lines. Both T- and B-cell lymphoma cell lines harboring methylation-mediated inactivation of PCDH10 were resistant to doxorubicin treatment, suggesting that hypermethylation of this gene might contribute to chemotherapy response.
Analysis of Drain Lag and Power Compression in GaN MESFET
Creators: name: Horio, K.
name: Yonemoto, K.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2004
Subjects: ING-INF/01 Elettronica

description: Two-dimensional transient simulation of a
GaN MESFET is performed in which deep levels in a semiinsulating
buffer layer is considered. It is shown that the
drain voltage VD is raised, the drain current overshoot the
steady-state value, and when VD is lowered, the drain
current remains at a low value for some periods, showing
drain lag behavior. This drain lag is shown to become a
cause of so-called power compression in the GaN MESFET.
Targeting SLMAP-ALK—a novel gene fusion in lung adenocarcinoma
Creators: name: Pagan, Carlos A.
name: Barua, Subit
name: Hsiao, Susan
name: Mansukhani, Mahesh M.
name: Saqi, Anjali
name: Vundavalli, Murty V.
name: Fernandes, Helen
Publisher: name: Columbia University
Year: 2019
Subjects: Lungs--Cancer
Gene rearrangement
Adenocarcinoma
Lungs--Cancer--Diagnosis

description: Assessment of ALK gene rearrangements is strongly recommended by the Molecular Testing Guideline for Selection of Lung Cancer Patients proposed by IASLC, AMP, and CAP at the time of diagnosis for patients with advanced stage disease. Non- small-cell lung cancer (NSCLC) with ALK gene rearrangements or the resulting fusion pro- teins have been, for the most part, successfully targeted with ALK tyrosine kinase inhibitors (TKIs). The most frequent rearrangement, the EML4-ALK oncogenic fusion, has more than 10 distinct variants, each with a discrete breakpoint in EML4. Recent studies have suggested that EML4-ALK variants may have differential responses to TKIs. Additionally, non-EML4- ALK fusions that result from ALK rearrangements with diverse 5′ partners could possibly have varied biologic and clinical implications in their therapeutic responses and outcomes of patients with NSCLC. Existing literature documents at least 20 non-EML4 fusion partners for ALK, and the clinical responsiveness to crizotinib ranges from increased sensitivity to re- sistance. This underscores the importance of identifying the precise 5′ fusion partner to ALK before initiation of therapy. Herein we report the identification of a novel SLMAP-ALK fusion in a patient with NSCLC.
Transient Analysis of Collector Current Collapse In Power HBTs
Creators: name: Sommet, R.
name: Lopez, D.
name: Quéré, R.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2002
Subjects: ING-INF/01 Elettronica

description: This paper describes the dynamic of the current collapse phenomenon that can occur in a multifinger power HBT. The electrothermal model used is a self consistent model based on an electrical distributed Ebers Moll model coupled to a thermal subcircuit derived from Ritz vector reduction technique of 3D thermal finite element simulation. Simulation of static as well as dynamic collector current collapse for HBT has been performed and allows to optimize the ballast resistor.
A T-odd Momentum Correlation in Radiative β-Decay
Creators: name: Gardner, Susan
name: He, Daheng
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We consider neutron radiative β-decay, n\to p e^- \barν_eγ, and compute the T-odd momentum correlation in the decay rate characterized by the kinematical variable ξ= {\bf l}_ν\cdot ({\bf l}_e\times{\bf k}) arising from electromagnetic final-state interactions in the Standard Model. Our expression for the corresponding T-odd asymmetry A_ξ^{SM} is exact in O(α) up to terms of recoil order, and we evaluate it numerically under various kinematic conditions. Noting the universality of the V-A law in the absence of recoil order terms, we retain the parametric dependence on masses and coupling constants throughout, so that our results serve as a template for the computation of A_ξ^{SM} in allowed nuclear radiative β-decays and hyperon radiative β-decays as well. We consider the pattern of A_ξ^{SM} which appears in nuclear decays and show that A_ξ^{SM} can be suppressed in particular cases, facilitating searches for new sources of CP-violation in such processes.
description: 24 pages, 6 figures; published version
Behind the counter : migration, labour policy and temporary work in a global fast food chain
Creators: name: Polanco Sorto, Aida Geraldina
Publisher: name: University of British Columbia
Year: 2014

description: This dissertation explores the shift from local to global recruitment practices in western Canada’s low-waged service sector, with fast food and Tim Hortons serving as the industry and case study for this project. By examining the recent expansion to Canada’s Temporary Foreign Worker Program, I show how a market-driven immigration program is resulting in new flows of workers entering Canada for low-waged occupations like fast food service. These workers are primarily young, educated, eager and able-bodied male and female migrant workers recruited disproportionately from the Philippines. They are new in the sense that they are part of a highly qualified flow of migrants who no longer have the opportunity to permanently immigrate and become full members of the Canadian polity. They enter Canada in pursuit of the classical immigrant dream only to discover that the context of reception has changed. They are recruited through a labour migration program that offers migrants few if any opportunities to transition from temporary to permanent residency status, and one that encourages migrants to compete for permanent residency within the worksite, at improbable odds. This study draws from 62 semi-structured interviews, ethnographic field research conducted in Canada and the Philippines, and freedom of information data gathered on Tim Hortons’ recruitment practices of migrant workers in Alberta and British Columbia. I show how: the tourism and hospitality industry was instrumental for institutionalizing an employer-friendly market driven immigration program; how the Filipino migration apparatus seeks to deliver culturally appropriate workers to foreign employers; how the turn to migrant labour by fast food is providing employers with young, able-bodied and an industry-preferred workforce; and how the Canadian dream operates to enlist the consent of migrant workers within the worksite. This study has implications beyond fast food and western Canada given the proliferation of migrant worker programs on a global scale, and the status of Canada and the Philippines as model immigration and labour programs.
Scalable Large Signal Modeling of InGaP/GaAs HBT for CAD Tools
Creators: name: Suh, Y.S.
name: Han, K.-Y.
name: Ahn, C.-H.
name: Heo, D.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2002
Subjects: ING-INF/01 Elettronica

description: A new HBT current source model and the corresponding direct parameter extraction methods are presented. Exact analytical expressions for the current source model parameter are derived. This method is applied to scalable modeling of HBT. Some techniques to reduce redundancy of the parameters are introduced. The model based on this method can accurately predict the measured data for the change of ambient temperature, size, and bias.
Shared data files for "Failure Mechanism in Protonic Ceramic Fuel Cells (PCFCs) Under Gaseous Cr and CO2 Exposure and the Introduction of Protective Barrier Layer for Mitigation"
Creators: name: Yang, Sungeun
Publisher: name: Zenodo
Year: 2024

description: The data is a shared data files for a scientific article titled "Failure Mechanism in Protonic Ceramic Fuel Cells (PCFCs) Under Gaseous Cr and CO2 Exposure and the Introduction of Protective Barrier Layer for Mitigation".

The data includes raw electron microscopy files and XRD data along with TEM image data
A 18 GHz MMIC biquad active filter
Creators: name: Avitabile, G.
name: Chellini, B.
name: Giannini, F.
name: Limiti, E.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2002
Subjects: ING-INF/01 Elettronica

description: A high-Q bandpass biquad filter operating at 18GHz is proposed. It is based on an active parallel resonator and it is suitable for MMIC implementation. A prototype has been implement ed using the Philips ED02AH PHEMT foundry process. A quality factor of 120 at 18GHz with a current consumption of 5mA @ 2V bias has been reported.
Additional file 1 of Needs of patients with dementia and their caregivers in primary care: lessons learned from the Alzheimer plan of Quebec
Creators: name: Khanassov, Vladimir
name: Rojas-Rozo, Laura
name: Sourial, Rosa
name: Yang, Xin Qiang
name: Vedel, Isabelle
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1.
Highly-Integrated X-band Multi-function MMIC with Integrated LNA and Driver Amplifier
Creators: name: De Boer, A.
name: Hoogland, J.A.
name: Suijker, E.M.
name: Van Wanum, M.
name: Van Vliet, F.E.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2002
Subjects: ING-INF/01 Elettronica

description: The design and performance of a highly integrated X-band multi-function MMIC with integrated LNA and high output power will be discussed. The MMIC integrates all the control functions of a transmit/receive module. The integration of a Low Noise Amplifier and Driver Amplifier makes this MMIC extremely suitable for a two chip T/R module solution. The MMIC is realised in the 0.25µm PHEMT (PH25) process of UMS.
From the Cooper problem to canted supersolids in Bose-Fermi mixtures
Creators: name: Anders, Peter
name: Werner, Philipp
name: Troyer, Matthias
name: Sigrist, Manfred
name: Pollet, Lode
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We calculate the phase diagram of the Bose-Fermi Hubbard model on the 3d cubic lattice at fermionic half filling and bosonic unit filling by means of single-site dynamical mean-field theory. For fast bosons, this is equivalent to the Cooper problem in which the bosons can induce s-wave pairing between the fermions. We also find miscible superfluid and canted supersolid phases depending on the interspecies coupling strength. In contrast, slow bosons favor fermionic charge density wave structures for attractive fermionic interactions. These competing instabilities lead to a rich phase diagram within reach of cold gas experiments.
description: 5 pages, 4 figures; replaced with published version
Additional file 1 of Plasma inflammatory cytokines and treatment-resistant depression with comorbid pain: improvement by ketamine
Creators: name: Zhou, Yanling
name: Wang, Chengyu
name: Lan, Xiaofeng
name: Li, Hanqiu
name: Chao, Ziyuan
name: Ning, Yuping
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Table S1. Change in depressive symptoms and pain intensity in pain group and non-pain group. Abbreviations: MADRS, Montgomery-Asberg Depression Rating Scale; VAS, Visual Analogue Scale; PPI, Present Pain Intensity. Table S2. Baseline plasma levels of inflammatory cytokines in pain group, non-pain group and healthy controls. Abbreviations: ITAC, interferon-inducible T cell alpha chemoattractant; GM-CSF, granulocyte macrophage colony-stimulating factor; IFN, interferon; IL, interleukin; MIP, macrophage inflammatory protein; TNF, tumor necrosis factor; HCs, healthy controls. Table S3. Comparison of inflammatory cytokines levels between groups using linear mixed model analysis. Abbreviations: ITAC, interferon-inducible T cell alpha chemoattractant; GM-CSF, granulocyte macrophage colony-stimulating factor; IFN, interferon; IL, interleukin; MIP, macrophage inflammatory protein; TNF, tumor necrosis factor.
A Highly Linear Mixer For Zero-IF Bluetooth Receiver
Creators: name: Cidronali, A.
name: Collodi, G.
name: Magrini, I.
name: Manes, G.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2002
Subjects: ING-INF/01 Elettronica

description: In this paper a compact and highly linear monolithic integrated circuit (MMIC) suitable for zero-IF Bluetooth receiver is described. The prototype is designed in order to overcome the drawbacks that homodyne receivers present, like flicker noise, LO leakage and sensitivity to the 2-nd, 3-rd order intermodulation products. For these tasks a passive sub-harmonic topology has been utilized. The fabricated prototype exhibites a 3-rd order intercept point of +30dBm, 2-nd order intercept point of +98dBm, conversion loss of 8dB, 1-dB compression point of +4 dBm and better than 50dB small signal isolation RF and LO ports.
Fast Tuning Electronically Switched 16 x 1 Channel Receiver For Packet-Switched WDM Systems
Creators: name: Manfrin, S.K.
name: De Dominicis, M.
name: Orengo, G.
name: Giannini, F.
name: Romero, M.A.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2002
Subjects: ING-INF/01 Elettronica

description: This paper revisits an optical receiver topology, for a wavelength division multiplexing (WDM) optical network at 2.5 Gbps bit rate, based on non-tunable wavelength demultiplexing and electronic switching.We demonstrate novel, monolithically integrated, four-channel optical receiver module composed of MESFET transimpedance amplifiers and switches that can be independently switched “on” or “off” electronically by a digital signal. The selector chips have also been reconfigured as a 16 channel selector array. Frequency and noise performance as well as switching speed and crosstalk between neighboring channels have been investigated.
Additional file 1 of Identification of persistent and resolving subphenotypes of acute hypoxemic respiratory failure in two independent cohorts
Creators: name: Sathe, Neha A.
name: Zelnick, Leila R.
name: Mikacenic, Carmen
name: Morrell, Eric D.
name: Bhatraju, Pavan K.
name: McNeil, J. Brennan
name: Kosamo, Susanna
name: Hough, Catherine L.
name: Liles, W. Conrad
name: Ware, Lorraine B.
name: Wurfel, Mark M.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Additional file 1. Supplemental methods, figures, and tables.