cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Spectral proper orthogonal decomposition
Creators: name: Sieber, Moritz
name: Oberleithner, Kilian
name: Paschereit, Christian Oliver
Publisher: name: arXiv
Year: 2015
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: The identification of coherent structures from experimental or numerical data is an essential task when conducting research in fluid dynamics. This typically involves the construction of an empirical mode base that appropriately captures the dominant flow structures. The most prominent candidates are the energy-ranked proper orthogonal decomposition (POD) and the frequency ranked Fourier decomposition and dynamic mode decomposition (DMD). However, these methods fail when the relevant coherent structures occur at low energies or at multiple frequencies, which is often the case. To overcome the deficit of these "rigid" approaches, we propose a new method termed Spectral Proper Orthogonal Decomposition (SPOD). It is based on classical POD and it can be applied to spatially and temporally resolved data. The new method involves an additional temporal constraint that enables a clear separation of phenomena that occur at multiple frequencies and energies. SPOD allows for a continuous shifting from the energetically optimal POD to the spectrally pure Fourier decomposition by changing a single parameter. In this article, SPOD is motivated from phenomenological considerations of the POD autocorrelation matrix and justified from dynamical system theory. The new method is further applied to three sets of PIV measurements of flows from very different engineering problems. We consider the flow of a swirl-stabilized combustor, the wake of an airfoil with a Gurney flap, and the flow field of the sweeping jet behind a fluidic oscillator. For these examples, the commonly used methods fail to assign the relevant coherent structures to single modes. The SPOD, however, achieves a proper separation of spatially and temporally coherent structures, which are either hidden in stochastic turbulent fluctuations or spread over a wide frequency range.
title: Die Komplikationen der radikalen Zystektomie mit Harnableitung: Eine retrospektive, monozentrische Studie
Creators: name: Haas, Maximilian
name: Siebertz, Leopold
name: Huber, Toni
name: Pickl, Christoph
name: Gierth, Michael
name: Breyer, Johannes
name: Burger, Maximilian
name: Mayr, Roman
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Die radikale Zystektomie ist eine Operation, die aufgrund des ausgedehnten chirurgischen Eingriffes und einer aggressiven Grunderkrankung mit einem hohen Risiko für Komplikationen vergesellschaftet ist. Ziel dieser Studie war es, die Komplikationen der radikalen Zystektomie objektiv,[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 45. Gemeinsame Tagung der Österreichischen Gesellschaft für Urologie und Andrologie und der Bayerischen Urologenvereinigung
title: Ecosystem services for communities in forest frontiers: An assessment of nature’s benefits to local stakeholders under different land use and tenure systems in a tropical frontier landscape in Myanmar
Creators: name: Feurer, Mélanie
Publisher: name: Universität Bern
Year: 2022
Subjects: subject: 910 Geography & travel

description: Tropical forest frontier landscapes are subject to land use changes and different claims on land by various actors, often leading to trade-offs and a general decline in ecosystem services (ES) for local communities. However, few comprehensive ES studies have been done in such data-scarce frontier regions and they are limited in terms of area, land uses, and number and types of ES assessed. This doctoral thesis aimed to analyse how local stakeholders in Myanmar’s Tanintharyi Region can benefit from various ES and how these are associated to different factors such as land use, land tenure, market access, or population structures. Applying advanced modelling techniques, I used Bayesian networks to model the supply, demand, flow and final outcomes of nine ES: subsistence foods, commercial products, fuelwood, medicinal plants, biodiversity, climate regulation, water regulation, environmental education, and cultural identity. The models were developed in an iterative process and integrated existing spatial datasets, census data and qualitative data from focus group discussions and interviews with local communities, government representatives, researchers, civil society organizations and non-governmental institutions working on land issues in Tanintharyi. I linked the nine models to spatial data to map ES supply, demand, and flow for local stakeholders across the region. Finally, I combined these maps to identify supply/demand (mis)matches as well as accessibility that particularly affects local communities. The thesis highlights the value of mosaic landscapes and the crucial role of equitable land tenure in tropical forest frontiers for providing multiple ES and enhancing human well-being.
Artificial gauge fields in the t-z mapping for optical pulses: spatio-temporal wavepacket control and quantum Hall physics
Creators: name: Oliver, Christopher
name: Mukherjee, Sebabrata
name: Rechtsman, Mikael C.
name: Carusotto, Iacopo
name: Price, Hannah M.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Optics (physics.optics)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We extend the $t-z$ mapping formalism of time-dependent paraxial optics by identifying configurations displaying a synthetic magnetic vector potential, leading to a non-trivial band topology in propagating geometries. We consider an inhomogeneous 1D array of coupled optical waveguides beyond the standard monochromatic approximation, and show that the wave equation describing paraxial propagation of optical pulses can be recast in the form of a Schrödinger equation, including a synthetic magnetic field whose strength can be controlled via the transverse spatial gradient of the waveguide properties across the array. We use an experimentally-motivated model of a laser-written waveguide array to demonstrate that this synthetic magnetic field can be engineered in realistic setups and can produce interesting observable effects such as cyclotron motion, a controllable Hall drift of the wavepacket displacement in space or time, and unidirectional propagation in chiral edge states. These results significantly extend the variety of physics that can be explored within propagating geometries and pave the way for exploiting this platform for higher-dimensional topological physics and strongly correlated fluids of light.
Gaussian random field power spectrum and the Sérsic law
Creators: name: Nipoti, Carlo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The surface-brightness profiles of galaxies are well described by the Sérsic law: systems with high Sérsic index m have steep central profiles and shallow outer profiles, while systems with low m have shallow central profiles and steep outer profiles. R. Cen (2014, ApJL, 790, L24) has conjectured that these profiles arise naturally in the standard cosmological model with initial density fluctuations represented by a Gaussian random field (GRF). We explore and confirm this hypothesis with N-body simulations of dissipationless collapses in which the initial conditions are generated from GRFs with different power spectra. The numerical results show that GRFs with more power on small scales lead to systems with higher m. In our purely dissipationless simulations the Sérsic index is in the range 2
description: 6 pages, 2 figures, accepted for publication in the ApJL
Acigonium spinosa P. A. Sims & D. M. Williams 2018, comb. nov.
Creators: name: Sims, Pat A.
name: Williams, David M.
name: Ashworth, Matt
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Chromista
Ochrophyta
Bacillariophyceae
Triceratiales
Parodontellaceae
Acigonium
Acigonium spinosa

description: Acigonium spinosa (Greville) P.A. Sims & D. M. Williams, comb. nov. (Figs 21–28)
 Basionym: Biddulphia spinosa Greville (1865a: 6, pl. 1, fig. 3) non Biddulphia spinosa (Bailey) Boyer 1900: 703 (= Triceratium spinosum Bailey 1844: 139, pl. 3, fig. 12 = Biddulphia setigera ??)
 Synonyms:— Odontella spinosa (Greville) Grunow (1884: 58)? Denticella spinosa (Greville) Grunow (1884: 58)
 Type:— Barbadoes 1865; Cambridge, Barbadoes Johnson 1864 (BM 3114?, BM 3125, syntypes)
Valves lanceolate with acuminate apices (Figs 21, 23). Valve face narrow to broadly lanceolate bordered by well developed marginal ridge (Figs 22, 26). Valve length 65–100um, breadth 28–50um, 18 striae in 10um on valve mantle. Valve face with outwardly directed elevation at each pole (Fig. 23) with circular ocellus on distal face of summit (Figs 24, 28). Areolae loculate, with internal foramina (Fig. 24). On exterior of valve face rows of fine pores lie within irregular pattern of square to rectangular hyaline walls (Figs 25, 27). On mantle fine pores lie in vertical rows, on valve face in transverse rows meeting at central sternum (Figs 25, 27). Rimoportulae 6–9, opening through long hollow spines, expanded at base where they penetrate the marginal ridge (Figs 25, 26).
 Observations:— The description above is based on material from Barbados, Vema CAS locality no. 39573/8 (‘Vema Cruise 17 South Atlantic, Core Number 107, Water Depth 1525, From top of Core 50 cm. 3–55 cm’, BM; details of the Vema material can be found in Hanna et al. 1976). The valve face on specimens from Barbados appears to be broadly lanceolate, whilst those from Vema are narrow and lanceolate.
 For details of Acigonium gladarmatum Komura and A. gladiorum Komura see Komura (1999).
description: Published as part of Sims, Pat A., Williams, David M. & Ashworth, Matt, 2018, Examination of type specimens for the genera Odontella and Zygoceros (Bacillariophyceae) with evidence for the new family Odontellaceae and a description of three new genera, pp. 1-56 in Phytotaxa 382 (1) on page 10, DOI: 10.11646/phytotaxa.382.1.1, http://zenodo.org/record/13724044
Nash multiplicities and resolution invariants
Creators: name: Bravo, A.
name: Encinas, S.
name: Pascual-Escudero, B.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14E15, 14J17

description: The Nash multiplicity sequence was defined by M. Lejeune-Jalabert as a non-increasing sequence of integers attached to a germ of a curve inside a germ of a hypersurface. M. Hickel generalized this notion and described a sequence of blow ups which allows us to compute it and study its behavior. In this paper, we show how this sequence can be used to compute some invariants that appear in algorithmic resolution of singularities.
description: minor corrections, 42 pages
title: Androgenresistenz als Ursache für Difference of Sex Development (DSD) und Infertilität
Creators: name: Turba, Simon
name: Lintner, Christian
name: Breinl, Eckart
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Innerhalb eines sehr vereinfachten Modells wird Hypogonadismus klassischerweise bei Patienten mit typischer Symptomatik und niedrigen Testosteronspiegel diagnostiziert. Sowohl Veränderungen des nukleären Androgenrezeptors (AR) selbst als auch unzähliger mit ihm interagierender Proteine[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 45. Gemeinsame Tagung der Österreichischen Gesellschaft für Urologie und Andrologie und der Bayerischen Urologenvereinigung
Precision Modulation of Neurodegenerative Disease-Related Gene Expression in Human iPSC-Derived Neurons
Creators: name: Wood, Matthew John Andrew
name: Heman-Ackah, Sabrina Mahalia
name: Bassett, Andrew Roger
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The ability to reprogram adult somatic cells into induced pluripotent stem cells (iPSCs) and the subsequent development of protocols for their differentiation into disease-relevant cell types have enabled in-depth molecular analyses of multiple disease states as hitherto impossible. Neurons differentiated from patient-specific iPSCs provide a means to recapitulate molecular phenotypes of neurodegenerative diseases in vitro. However, it remains challenging to conduct precise manipulations of gene expression in iPSC-derived neurons towards modeling complex human neurological diseases. The application of CRISPR/Cas9 to mammalian systems is revolutionizing the utilization of genome editing technologies in the study of molecular contributors to the pathogenesis of numerous diseases. Here, we demonstrate that CRISPRa and CRISPRi can be used to exert precise modulations of endogenous gene expression in fate-committed iPSC-derived neurons. This highlights CRISPRa/i as a major technical advancement in accessible tools for evaluating the specific contributions of critical neurodegenerative disease-related genes to neuropathogenesis.
title: Die Assoziation von Samenleukozyten, Interleukin-6 und Interleukin-8 mit Fragmentierung der Spermien-DNA
Creators: name: Aghazarian, Artin
name: Huf, Wolfgang
name: Pflüger, Heinz
name: Klatte, Tobias
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Ziel: Die Evaluierung der Korrelation der Spermien-DNA-Integrität mit den Markern der Samenentzündung und Routinespermienparametern. Material und Methode: Wir untersuchten Samenleukozyten, Interleukin (IL) -6, IL-8 und Routinespermienparameter bei 134 aufeinander folgenden Männern.[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 45. Gemeinsame Tagung der Österreichischen Gesellschaft für Urologie und Andrologie und der Bayerischen Urologenvereinigung
Coupled $ππ, K\overline{K}$ scattering in $P$-wave and the $ρ$ resonance from lattice QCD
Creators: name: Wilson, David J.
name: Briceno, Raul A.
name: Dudek, Jozef J.
name: Edwards, Robert G.
name: Thomas, Christopher E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We determine elastic and coupled-channel amplitudes for isospin-1 meson-meson scattering in $P$-wave, by calculating correlation functions using lattice QCD with light quark masses such that $m_π= 236$ MeV in a cubic volume of $\sim (4 \,\mathrm{fm})^3$. Variational analyses of large matrices of correlation functions computed using operator constructions resembling $ππ$, $K\overline{K}$ and $q\bar{q}$, in several moving frames and several lattice irreducible representations, leads to discrete energy spectra from which scattering amplitudes are extracted. In the elastic $ππ$ scattering region we obtain a detailed energy-dependence for the phase-shift, corresponding to a $ρ$ resonance, and we extend the analysis into the coupled-channel $K\overline{K}$ region for the first time, finding a small coupling between the channels.
description: matches published version, minor typos corrected
Parodontella fimbriata D. M. Williams & P. A. Sims 2018, comb. nov.
Creators: name: Sims, Pat A.
name: Williams, David M.
name: Ashworth, Matt
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Chromista
Ochrophyta
Bacillariophyceae
Triceratiales
Parodontellaceae
Parodontella
Parodontella fimbriata

description: Parodontella fimbriata (Greville) D. M. Williams & P.A. Sims, comb. nov. (Figs 44–50)
 Basionym:— Biddulphia fimbriata Greville (1865a: 6, pl. 1, fig. 4) non Biddulphia fimbriata (Wallich) Mann (1925: 39) (= Triceratium fimbriatum Wallich 1858: 247, pl. 12, figs 4–9)
 Synonyms:— Odontella fimbriata (Greville) Grunow (1884: 58)? Denticella fimbriata (Greville) Grunow (1884: 58) Odontella fimbriata (Greville) Schrader in Schrader & Fenner (1976: 992, pl. 20, fig. 6), nom. superfl.
 Type:— Barbadoes, Johnson 1863, 1864 (BM 3186 (1863), lectotype; BM 3197 (1864), syntypes).
Valves broadly lanceolate with acuminate apices (Figs 44–47), length 187–225μm (Greville’s specimen measures 92.5–102μm) breadth 104–109μm, striae on mantle exterior c. 15 in 10μm. Valve face lanceolate with outwardly directed slightly curved elevations at each pole (Figs 46–47), ocellus on distal side of summit (Fig. 48). Well-developed marginal ridge of solid spines, fused at base, separates valve face from deep mantle expanded at its centre (Figs 44, 47). Valve structure loculate with internal foramina (Fig. 50), exterior with single or double rows of slightly radially aligned poroids between hyaline lines on valve face (Fig. 49) and between barely raised costae on mantle (Fig. 48). Spinules, some long, on valve face and mantle (Fig. 49). Rimoportulae 8–12, opening through very long slender spines lying on each side of valve face just within marginal ridge (Fig. 47). Internal opening a slit across a sunken papillus (Fig. 50).
 Observations:— The description above is based on material from Sengilei, Russia (BM). It has been found in: Cambridge, Barbadoes (Johnson in Greville 1865a); Navarin Basin Province, Bering Sea (Baldauf & Barron 1987: Pl. 10, fig. 15); Oligocene sediments of the Norwegian Sea (Schrader & Fenner 1976); lower Oligocene sediments of the southwestern Pacific (Hajós 1976: Pl. 22, figs 7, 8).
description: Published as part of Sims, Pat A., Williams, David M. & Ashworth, Matt, 2018, Examination of type specimens for the genera Odontella and Zygoceros (Bacillariophyceae) with evidence for the new family Odontellaceae and a description of three new genera, pp. 1-56 in Phytotaxa 382 (1) on page 13, DOI: 10.11646/phytotaxa.382.1.1, http://zenodo.org/record/13724044
title: Erektile Rehabilitation mit niedrig-dosiertem Sildenafil: Der Erhalt der nächtlichen penilen Tumeszenzen 6 Wochen nach nervenerhaltender radikaler Prostatektomie korreliert mit der weiteren Rehabilitation der erektilen Funktion nach 12 Monaten
Creators: name: Bannowsky, Andreas
name: Steinhagen, Cindy
name: Wedel, Caroline
name: Bothe, Katrin
name: Armbrust, Florian
name: Fuchs, Julia
name: Ückert, Stefan
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: In vorangegangenen Studien konnte gezeigt werden, dass die tägliche Einnahme von niedrig-dosiertem Sildenafil (25 mg) zu einem signifikanten Erhalt der nächtlichen Erektionen 6 Wochen nach nervenerhaltender radikaler Prostatektomie (nsRP) führt. Ziel dieser Studie war, ob [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 45. Gemeinsame Tagung der Österreichischen Gesellschaft für Urologie und Andrologie und der Bayerischen Urologenvereinigung
Stewardship of Prehospital Low Titer O-Positive Whole Blood in a Large Urban Fire-Based EMS System
Creators: name: Bullock, William
name: Schaefer, Randall
name: Wampler, David
name: Stringfellow, Michael
name: Dieterle, Mark
name: Winckler, Christopher “CJ”
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Cardiology

description: Introduction: Trauma is the leading cause of death for those aged 1 to 46 years with most fatalities resulting from hemorrhage prior to arrival to hospital. Hemorrhagic shock patients receiving transfusion with 15 minutes experience lower mortality. Prehospital blood transfusion has many legal, fiduciary, and logistical issues. The San Antonio Fire Department participates in a consortium designed to enhance the stewardship of prehospital whole blood. This study aimed to stratify blood usage amongst the field supervisors and special operations units that carry whole blood. Methods: This was a 12-month retrospective analysis of blood usage. Blood tracking forms (used for either blood exchange of transfusion) were cross referenced with city financial records to determine blood usage patterns in the 7th Largest City in the US. We used descriptive statistics, compared usage ratios, and chi-square to compare dichotomized data. Results: A total of 363 whole blood units were obtained and 248 (68.3%) units of whole blood were transfused. EMS field supervisors transfused 74% of whole blood vs. 44% for special operations ambulances (p= <0.001). Response vehicles located in densely populated areas had the highest usage rates. All blood units were either transfused or returned for a zero blood unit wastage for expiration. Conclusion: The information contained within this work can provide other EMS agencies with a basic framework for comparison. The data from the SAFD’s whole blood transfusion rate coupled with the clinical transfusion guideline has provided some insight for prospective agencies considering adopting a whole blood program. EMS systems and municipalities with similar characteristics can project their own whole blood needs and make informed decisions regarding program feasibility and design.
Survival after Resuscitated Out-of-Hospital Cardiac Arrest in Patients with Paramedic-Identified ST-Segment Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention
Creators: name: Doan, Tan N.
name: Prior, Marcus
name: Vollbon, William
name: Rogers, Brett
name: Rashford, Stephen
name: Bosley, Emma
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Background: ST-segment elevation myocardial infarction (STEMI) is a common cause of out-of-hospital cardiac arrest (OHCA). For these patients, urgent angiography and revascularization is an important treatment goal. There is a lack of data on the prognosis of STEMI patients after OHCA, who are diagnosed and treated by paramedics prior to hospital transport for primary percutaneous coronary intervention (PCI). Methods: Included were adult STEMI patients identified and treated by paramedics in Queensland (Australia) from January 2016 to December 2019, transported to a hospital for primary PCI, and receiving primary PCI. Patients were grouped into those with resuscitated OHCA and those without OHCA. Clinically-important time intervals, angiographic and clinical profiles, and survival were described. Results: Patients with OHCA had longer time intervals from prehospital STEMI identification to reperfusion than those without OHCA (median 97 versus 87 mins, p = 0.001). The former had higher rates of cardiac arrhythmia history (50.5 versus 12.4%, p < 0.001), classified low left ventricular ejection fraction on admission (64.9 versus 50.1%, p = 0.006), and cardiogenic shock (5.2 versus 1.2%, p = 0.011) than the latter. A significantly higher proportion of patients with OHCA had multiple diseased vessels (16.9 versus 8.3%, p = 0.005). In-hospital, 30-day, and one-year mortality was low, being 4.1%, 4.1% and 5.2%, respectively, for STEMI patients with OHCA. The corresponding figures for those without OHCA were 1.6%, 1.8% and 3.3%, respectively. Conclusions: Survival in paramedic-identified STEMI patients treated with primary PCI following OHCA resuscitation was high. Rapid angiography and reperfusion are critical in these patients.
title: Assoziation von Masturbation und funktionellem Outcome im postoperativen Verlauf nach nervschonender radikaler Prostatektomie
Creators: name: Meissner, Valentin Henri
name: Dumler, Sonja
name: Kron, Martina
name: Schiele, Stefan
name: Bannowsky, Andreas
name: Gschwend, Jürgen Erich
name: Herkommer, Kathleen
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Fragestellung/Ziel: Die penile Rehabilitation nach nervschonender radikaler Prostatektomie (nsRP) beeinflusst das funktionelle Outcome (erektile Funktion und Kontinenz) positiv. Dabei werden postoperativ Medikamente/Hilfsmittel eingesetzt, um die Erektionsfähigkeit zu verbessern. Ob auch[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 45. Gemeinsame Tagung der Österreichischen Gesellschaft für Urologie und Andrologie und der Bayerischen Urologenvereinigung
Proteomic dissection of LPS-inducible, PHF8-dependent secretome reveals novel roles of PHF8 in TLR4-induced acute inflammation and T cell proliferation
Creators: name: Chen, Xian
name: Wu, Bing
name: Erdogan, Özgün
name: Wang, Li
name: Kong, Qing
name: Xie, Ling
name: Wan, Yisong
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Endotoxin (LPS)-induced changes in histone lysine methylation contribute to the gene-specific transcription for control of inflammation. Still unidentified are the chromatin regulators that drive the transition from a transcriptional-repressive to a transcriptional-active chromatin state of pro-inflammatory genes. Here, using combined approaches to analyze LPS-induced changes in both gene-specific transcription and protein secretion to the extracellular compartment, we characterize novel functions of the lysine demethylase PHF8 as a pro-inflammatory, gene-specific chromatin regulator. First, in the LPS-induced, acute-inflamed macrophages, PHF8 knockdown led to both a reduction of pro-inflammatory factors and an increase in a transcriptional-repressive code (H3K9me2) written by the methyltransferase G9a. Through unbiased quantitative secretome screening we discovered that LPS induces the secretion of a cluster of PHF8-dependent, ‘tolerizable’ proteins that are related to diverse extracellular pathways/processes including those for the activation of adaptive immunity. Specifically, we determined that PHF8 promotes T-cell activation and proliferation, thus providing the first link between the epigenetic regulation of inflammation and adaptive immunity. Further, we found that, in the acute-inflamed macrophages, the acute-active PHF8 opposes the H3K9me1/2-writing activity of G9a to activate specific protein secretions that are suppressed by G9a in the endotoxin-tolerant cells, revealing the inflammatory-phenotypic chromatin drivers that regulate the gene-specific chromatin plasticity.
Tides Alone Cannot Explain Kepler Planets Close to 2:1 MMR
Creators: name: Silburt, Ari
name: Rein, Hanno
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: A number of Kepler planet pairs lie just wide of first-order mean motion resonances (MMRs). Tides have been frequently proposed to explain these pileups, but it is still an ongoing discussion. We contribute to this discussion by calculating an optimistic theoretical estimate on the minimum initial eccentricity required by Kepler planets to explain the current observed spacing, and compliment these calculations with N-body simulations. In particular, we investigate 27 Kepler systems having planets within 6% of the 2:1 MMR, and find that the initial eccentricities required to explain the observed spacings are unreasonable from simple dynamical arguments. Furthermore, our numerical simulations reveal resonant tugging, an effect which conspires against the migration of resonant planets away from the 2:1 MMR, requiring even higher initial eccentricities in order to explain the current Kepler distribution. Overall, we find that tides alone cannot explain planets close to 2:1 MMR, and additional mechanisms are required to explain these systems.
description: Accepted for publication in MNRAS, 9 pages, 5 figures, 1 table
Identification of Non-Fatal Opioid Overdose Cases Using 9-1-1 Computer Assisted Dispatch and Prehospital Patient Clinical Record Variables
Creators: name: Ajumobi, Olufemi
name: Verdugo, Silvia R.
name: Labus, Brian
name: Reuther, Patrick
name: Lee, Bradford
name: Koch, Brandon
name: Davidson, Peter J.
name: Wagner, Karla D.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology
subject: Computational Biology

description: Background: The current epidemic of opioid overdoses in the United States necessitates a robust public health and clinical response. We described patterns of non-fatal opioid overdoses (NFOODs) in a small western region using data from the 9-1-1 Computer Assisted Dispatch (CAD) record and electronic Patient Clinical Records (ePCR) completed by EMS responders. We determined whether CAD and ePCR variables could identify NFOOD cases in 9-1-1 data for intervention and surveillance efforts. Methods: We conducted a retrospective analysis of 1 year of 9-1-1 emergency medical CAD and ePCR (including naloxone administration) data from the sole EMS provider in the response area. Cases were identified based on clinician review of the ePCR, and categorized as definitive NFOOD, probable NFOOD, or non-OOD. Sensitivity, specificity, positive and negative predictive values (PPV and NPV) of the most prevalent CAD and ePCR variables were calculated. We used a machine learning technique—Random-Forests (RF) modeling—to optimize our ability to accurately predict NFOOD cases within census blocks. Results: Of 37,960 9-1-1 calls, clinical review identified 158 NFOOD cases (0.4%), of which 123 (77.8%) were definitive and 35 (22.2%) were probable cases. Overall, 106 (67.1%) received naloxone from the EMS responder at the scene. As a predictor of NFOOD, naloxone administration by paramedics had 67.1% sensitivity, 99.6% specificity, 44% PPV, and 99.9% NPV. Using CAD variables alone achieved a sensitivity of 36.7% and specificity of 99.7%. Combining ePCR variables with CAD variables increased the diagnostic accuracy with the best RF model yielding 75.9% sensitivity, 99.9% specificity, 71.4% PPV, and 99.9% NPV. Conclusion: CAD problem type variables and naloxone administration, used alone or in combination, had sub-optimal predictive accuracy. However, a Random Forests modeling approach improved accuracy of identification, which could foster improved surveillance and intervention efforts. We identified the set of NFOODs that EMS encountered in a year and may be useful for future surveillance efforts.
title: Sexualverhalten ungarischer und deutscher MedizinstudentInnen mit Fokus auf den Einfluss neuer Medien
Creators: name: Herkommer, Kathleen
name: Höppler, Katharina
name: Kron, Martina
name: Schulwitz, H.
name: Takács, Olivia
name: Benyó, Mátyás
name: Gschwend, Jürgen E.
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Fragestellung/Ziel: In früheren Studien wurden vermehrt geschlechterspezifische Unterschiede (Frau vs. Mann) im Sexualverhalten untersucht, während das Ziel vorliegender Studie war, gleichgeschlechtliche Unterschiede (Frau vs. Frau; Mann vs. Mann) im Sexualverhalten von MedizinstudentInnen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 45. Gemeinsame Tagung der Österreichischen Gesellschaft für Urologie und Andrologie und der Bayerischen Urologenvereinigung
Analytic functions on tubes of non-Archimedean analytic spaces
Creators: name: Martin, Florent
name: Kappen, Christian
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Geometry (math.AG)
subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: Let $k$ be a discretely valued non-Archimedean field. We give an explicit description of analytic functions whose norm is bounded by a given real number $r$ on tubes of reduced $k$-analytic spaces associated to special formal schemes (those include $k$-affinoid spaces as well as open polydiscs). As an application we study the connectedness of these tubes. This generalizes (in the discretely valued case) a result of Siegfried Bosch. We use as a main tool a result of A.J. de Jong relating formal and analytic functions on special formal schemes and a generalization of de Jong's result which is proved in the joint appendix with Christian Kappen.
description: 19 pages; modifications in section 4 to drop the assumption that the rings are reduced; typos corrected and examples added; the appendix appears now as a joint appendix
Parodontella tenuicornis D. M. Williams & P. A. Sims 2018, comb. nov.
Creators: name: Sims, Pat A.
name: Williams, David M.
name: Ashworth, Matt
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Chromista
Ochrophyta
Bacillariophyceae
Triceratiales
Parodontellaceae
Parodontella
Parodontella tenuicornis

description: Parodontella tenuicornis (Greville) D. M. Williams & P.A. Sims, comb. nov. (Figs 51–55)
 Basionym: — Biddulphia tenuicornis Greville (1865b: 51, pl. 6, fig. 17)
 Synonyms: — Odontotropis tenuicornis (Greville) Grunow (1884: 60) Odontotropis tenuicornis (Greville) De Toni (1894: 881) Parodontella obliqua Komura (1999: 64, figs 16, 17, 107–123)
 Type:— “ Barbadoes, Cambridge Estate, Johnson 1862” (BM 2777!, holotype of Biddulphia tenuicornis); Nabuto beach, Boso Peninsula, central Japan (MPC-1653, holotype of Parodontella obliqua).
Valves broadly lanceolate with apiculate apices, long slender elevation at each pole and four long tubular spines, exterior openings of rimoportulae on valve face (Figs 51, 53). Valve length 42–19μm, breadth 15–53μm, mantle costae 19 in 10μm. Summit of elevation slightly expanded and flattened with 3–4 small marginal linking (?) spines on proximal face, inverted triangular ocellus on distal face (Fig. 54). Well-developed marginal ridge formed by fused mantle costae extending as solid spinules on summit, separates valve face from expanded semi-lanceolate mantle (Figs 52, 55). Areolae loculate, single or bi-seriate rows of poroids forming striae on mantle (Fig. 55), on valve face irregular transapical lines of poroids meeting at central sternum (Fig. 53, arrow). Long spines, expanded at base, opening on valve face, occasionally on mantle (Figs 52, 55). Rimoportulae 4, opening on valve face, through long tubular spines, flattened at base, 2 spines positioned sub-marginally at valve centre, 2 positioned either side of sternum towards elevations (Figs 51, 53). No interior view obtained.
 Observations:— The description above is based on material from Vema 39573 (9) (‘Vema Cruise 17 South Atlantic, Core Number 107, Water Depth 1525’, BM), Vema 39576/10 (‘Vema Cruise 12, South Atlantic, Core Number 46, Water Depth 1167 m; from top of Core 280; details of the Vema material can be found in Hanna et al. 1976) and Cambridge, Barbadoes (after Greville 1865b). Also found at Calvert County, Pöplein, Maryland, USA.
description: Published as part of Sims, Pat A., Williams, David M. & Ashworth, Matt, 2018, Examination of type specimens for the genera Odontella and Zygoceros (Bacillariophyceae) with evidence for the new family Odontellaceae and a description of three new genera, pp. 1-56 in Phytotaxa 382 (1) on pages 13-17, DOI: 10.11646/phytotaxa.382.1.1, http://zenodo.org/record/13724044
title: BipolEP vs. TUR-P – eine Interimsanalyse nach 16 Patienten
Creators: name: Pallauf, Maximilian
name: Drerup, Martin
name: Lusuardi, Lukas
name: Kunit, Thomas
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die bipolare Enukleation der Prostata (BipolEP) stellt eine alternative endoskopische Operationsmethode zur Behandlung der BPH dar. Rezent wurde eine von Prof. TRW Herrmann entwickelte Elektrode präsentiert, welche die korrekte anatomische Enukleation der Prostata erleichtern soll. [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 45. Gemeinsame Tagung der Österreichischen Gesellschaft für Urologie und Andrologie und der Bayerischen Urologenvereinigung
A One-Year Cross Sectional Analysis of Emergency Medical Services Utilization and Its Association with Hypertension in Pregnancy
Creators: name: Hutchcraft, Megan L.
name: Ola, Oluwabusola
name: McLaughlin, Eric M.
name: Hade, Erinn M.
name: Murphy, Andrew J.
name: Frey, Heather A.
name: Larrimore, Ashley
name: Panchal, Ashish R.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Objective: To evaluate the prehospital obstetric population that utilizes emergency medical services (EMS) and their association with hypertensive disorders of pregnancy. Methods: We conducted a retrospective evaluation of one year of all medical calls from a large, municipal, midwestern fire department. Inclusion criteria included all pregnant patients transported to a hospital by EMS. Descriptive statistics were calculated to evaluate prehospital event information (e.g., zip code, time, and duration of call), patient characteristics, and clinical management data regarding blood pressure. Census data were used to compare neighborhood information with poverty rates. Results: Of the 1,575 identified patients, 64.4% (1015/1575) presented with obstetric complaints, 57.4% (700/1220) were in their third trimester and 72.7% (686/944) were multiparous. The median call duration was 17 (interquartile range 12–22) minutes. In the areas where EMS usage was highest, one quarter of individuals lived below the poverty level. Of the studied population, 32.0% (504/1575) were found to be hypertensive; 14.9% (75/504) of hypertensive patients were found to have severe hypertension. Only one patient (1/1575, 0.06%) presented with a chief complaint of hypertension; the rest were discovered by EMS. The highest rates of hypertension were noted in wealthier areas of the city. Patients with severe hypertension were more likely to present with seizures, consistent with eclampsia. Conclusion: Hypertension is common in the obstetric population using EMS. Prehospital management of hypertensive disorders of pregnancy may focus on identification and treatment of severe pre-eclampsia or eclampsia. Areas with longer call times may consider treatment of severe hypertension. Prehospital treatment of hypertensive disorders of pregnancy could be optimized.
Assessing Mass Loss and Stellar-to-Halo Mass Ratio of Satellite Galaxies: A Galaxy-Galaxy Lensing Approach Utilizing DECaLS DR8 Data
Creators: name: Wang, Chunxiang
name: Li, Ran
name: Shan, Huanyuan
name: Xu, Weiwei
name: Yao, Ji
name: Jing, Yingjie
name: Gao, Liang
name: Li, Nan
name: Xie, Yushan
name: Zhu, Kai
name: Yang, Hang
name: Chen, Qingze
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The galaxy-galaxy lensing technique allows us to measure the subhalo mass of satellite galaxies, studying their mass loss and evolution within galaxy clusters and providing direct observational validation for theories of galaxy formation. In this study, we use the weak gravitational lensing observations from DECaLS DR8, in combination with the redMaPPer galaxy cluster catalog from Sloan Digital Sky Survey data (SDSS) DR8 to accurately measure the dark matter halo mass of satellite galaxies. We confirm a significant increase in the stellar-to-halo mass ratio of satellite galaxies with their halo-centric radius, indicating clear evidence of mass loss due to tidal stripping. Additionally, we find that this mass loss is strongly dependent on the mass of the satellite galaxies, with satellite galaxies above $10^{11}~{\rm M_{\odot}/h}$ experiencing more pronounced mass loss compared to lower mass satellites, reaching 86\% at projected halo-centric radius $0.5R_{\rm 200c}$. The average mass loss rate, when not considering halo-centric radius, displays a U-shaped variation with stellar mass, with galaxies of approximately $4\times10^{10}~{\rm M_{\odot}/h}$ exhibiting the least mass loss, around 60\%. We compare our results with state-of-the-art hydrodynamical numerical simulations and find that the satellite galaxy stellar-to-halo mass ratio in the outskirts of galaxy clusters is higher compared to the predictions of the Illustris-TNG project about factor 5. Furthermore, the Illustris-TNG project's numerical simulations did not predict the observed dependence of satellite galaxy mass loss rate on satellite galaxy mass.
description: 14 pages, 9 figures
Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFRWT and EGFRT790M inhibitors
Creators: name: Al-Warhi, Tarfah
name: Al-Karmalawy, Ahmed A.
name: Elmaaty, Ayman Abo
name: Alshubramy, Maha A.
name: Abdel-Motaal, Marwa
name: Majrashi, Taghreed A.
name: Asem, Medhat
name: Nabil, Ahmed
name: Eldehna, Wagdy M.
name: Sharaky, Marwa
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer

description: Herein, a set of pyridine and pyrimidine derivatives were assessed for their impact on the cell cycle and apoptosis. Human breast cancer (MCF7), hepatocellular carcinoma (HEPG2), larynx cancer (HEP2), lung cancer (H460), colon cancers (HCT116 and Caco2), and hypopharyngeal cancer (FADU), and normal Vero cell lines were used. Compounds 8 and 14 displayed outstanding effects on the investigated cell lines and were further tested for their antioxidant activity in MCF7, H460, FADU, HEP2, HEPG2, HCT116, Caco2, and Vero cells by measuring superoxide dismutase (SOD), malondialdehyde content (MDA), reduced glutathione (GSH), and nitric oxide (NO) content. Besides, Annexin V-FITC apoptosis detection and cell cycle DNA index using the HEPG-2 cell line were established on both compounds as well. Furthermore, compounds 8 and 14 were assessed for their EGFR kinase (Wild and T790M) inhibitory activities, revealing eligible potential. Additionally, molecular docking, ADME, and SAR studies were carried out for the investigated candidates.
Nomenclature, comparative anatomy, and evolution of the reflected lamina of the angular in non-mammalian synapsids
Creators: name: Olroyd, Savannah L.
name: Sidor, Christian A.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: The reflected lamina of the angular has long been portrayed as a key component in understanding the evolution of the mammalian mandible and middle ear, yet the function of this structure in non-mammalian therapsids remains uncertain. We undertake a broad scale survey of two aspects of the reflected lamina that have been poorly characterized: the ridges and fossae on its lateral surface and the extent of the underlying angular cleft. These two features were visualized in a wide range of therapsids using CT data from the literature and blue light surface scanning. Most species exhibit a clade-specific pattern of surface topography, although dicynodonts are highly variable. A striking similarity in the general number and orientation of fossae and ridges is seen between the otherwise disparate therapsid clades, and we propose homologies in these surface features across Therapsida. These features may serve as useful phylogenetic characters in analyses of the relationships among the major therapsid clades. The angular cleft does not underlie all of what is often referred to as the ‘reflected lamina’ in the literature, and an updated definition of this term is provided. Several therapsid groups independently expanded the angular cleft to further separate the reflected lamina from the angular body. We discuss some functional consequences of our findings and note inconsistency between proposed clade-specific muscle attachment sites and the presence of homologous fossae and ridges across much of Therapsida.
title: Perioperative Evaluation von Holmium Laser Enukleation der Prostata (HoLEP) vs. Transurethrale Resektion der Prostata (TURP) bei Patienten unter Antikoagulation
Creators: name: Westhofen, Thilo
name: Magistro, Giuseppe
name: Gratzke, Christian
name: Stief, Christian G.
name: Weinhold, Philipp
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: HoLEP ist ein sicheres minimal invasives Laser-gestütztes OP-Verfahren, welches sich zur Therapie BPH-bedingter LUTS eignet. Eine zunehmende Anzahl von Patienten die eine operative Sanierung ihres BPS benötigen sind unter Therapie mit Thrombozytenaggregationhemmern (TAH) oder oraler Antikoagulation(AK).[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 45. Gemeinsame Tagung der Österreichischen Gesellschaft für Urologie und Andrologie und der Bayerischen Urologenvereinigung
Oscillatory orbits in the restricted elliptic planar three body problem
Creators: name: Guardia, Marcel
name: Martín, Pau
name: Sabbagh, Lara
name: Seara, Tere M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: The restricted planar elliptic three body problem models the motion of a massless body under the Newtonian gravitational force of the two other bodies, the primaries, which evolve in Keplerian ellipses. A trajectory is called oscillatory if it leaves every bounded region but returns infinitely often to some fixed bounded region. We prove the existence of such type of trajectories for any values for the masses of the primaries provided they make almost circular orbits.