cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Stability Tests of Alkynygold(I)(NHC) Complexes by HPLC-DAD-MS
Creators: name: Hoffmeister, Henrik
name: Ott, Ingo
Publisher: name: Universitätsbibliothek Braunschweig
Year: 2020
Subjects: subject: 615.19
subject: 660

description: Gold organometallic compounds have been extensively investigated as potential anticancer metallodrugs and have shown
a high potential regarding antiproliferative effects [Hickey, 2008; Andermark, 2016; Meyer, 2012; Schmidt, 2019].
Enhanced stability is a driving argument for the design of gold complexes with N-heterocyclic carbene (NHC) ligands.
The more surprising is the lack of methods of pharmaceutical analytics for their stability and solution chemistry. Such
analytical methods are important key elements for future metabolomic investigations and will help to ensure a better
understanding of the biological behavior of the complexes [Kostiainen, 2003].
We selected complexes of the type of alkynylgold(I)(NHC) for detailed stability studies by HPLC-DAD-MS, in
comparison to the well-known antirheumatic drug Auranofin. A RP-based chromatographic method was established to
separate possible degradation products of alkynylgold(I)(NHC) complexes. The stability studies were performed at 37°C
over 24h using dimethylformamide (DMF), dimethyl sulfoxide (DMSO), water and Dulbecco`s modified eagle medium
(DMEM) solutions of each compound. Furthermore, interaction experiments of alkynylgold(I)(NHC) complexes with
acetylcysteine are under way with the same set-up as the stability tests [Albert 2012].
ESI (+) and (-) ionisation with a quadrupole analyser was used for mass spectrometry. The first results indicate that
alkynylgold(I)(NHC) complexes are stable in the analysed solvents with no significant changes in their AUCs [Fig 2].
description: SPhERe Proceedings: 3rd International Symposium on Pharmaceutical Engineering Research
Inferring X-ray coronal structures from Zeeman-Doppler images
Creators: name: Jardine, M.
name: Wood, K.
name: Cameron, A. Collier
name: Donati, J. -F.
name: Mackay, D. H.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We have modelled the X-ray emission from the young rapid rotator AB Doradus (P = 0.514 days) using as a basis Zeeman-Doppler maps of the surface magnetic field. This allows us to reconcile the apparently conflicting observations of a high X-ray emission measure and coronal density with a low rotational modulation in X-rays. The technique is to extrapolate the coronal field from the surface maps by assuming the field to be potential. We then determine the coronal density for an isothermal corona by solving hydrostatic equilibrium along each field line and scaling the plasma pressure at the loop footpoints with the magnetic pressure. We set the density to zero along those field lines that are open and those where at any point along their length the plasma pressure exceeds the magnetic pressure. We then calculate the optically thin X-ray emission measure and rotational modulation for models with a range of coronal densities. Although the corona can be very extended, much of the emission comes from high-latitude regions close to the stellar surface. Since these are always in view as the star rotates, there is little rotational modulation. We find that emission measures in the observed range of 10^52.8 - 10^53.3 per cubic centimetre can be reproduced with densities in the range 10^9 - 10^10.7 per cubic centimetre for coronae at temperatures of 10^6-10^7 K.
description: 7 pages, 9 figures, to be published in Monthly Notices of the Royal Astronomical Society
title: Development of suitable working Protocol for in vitro Tape Stripping: A Case Study with biocompatible Aceclofenac-loaded topical Nanoemulsions
Creators: name: Ilić, Tanja
name: Savić, Sanela
name: Pantelić, Ivana
name: Marković, Bojan
name: Savić, Snežana
Publisher: name: Universitätsbibliothek Braunschweig
Year: 2020
Subjects: subject: tape stripping, porcine ear skin, nanoemulsions, in vitro-in vivo correlation, aceclofenac
subject: 615.19
subject: 660

description: Considering the numerous organizational and legislative issues associated with in vivo studies, the present study aimed
to develop in vitro tape stripping protocol that could serve as a prospective technique for skin penetration studies. The
research was mainly focused on the suitability of transepidermal water loss (TEWL) measurements, as a barrier
integrity test for porcine ear skin subjected to freezing/thawing procedure, as well as on the selection of the most
suitable device for pressing adhesive tapes onto the porcine ear surface during skin stripping procedure. Obtained
results suggest that TEWL measurements were able to detect the damage of the stratum corneum (SC) caused by
physical impairment (using adhesive tapes) and tissue degradation/dehydration (prolonged storage at –20ºC/ambient
conditions). Penetration profiles of aceclofenac from nanoemulsions based on sucrose esters or polysorbate 80 as
coemulsifiers, obtained in vitro (using a roller as pressure device), were in a good agreement with data obtained in vivo
on humans, supporting the use of developed in vitro tape-stripping protocol in skin formulation development and
optimization.
description: SPhERe Proceedings: 3rd International Symposium on Pharmaceutical Engineering Research
Energy and spatial resolution of a large volume liquid scintillator detector
Creators: name: Smirnov, O.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: The result of studies of the energy and spatial resolution of a large volume liquid scintillator detector are presented. The relations are obtained, which allows an estimation of the detector's energy and spatial resolutions without modeling. The relations are verified with the data obtained with the CTF detector, which is the prototype of the new detector for solar neutrinos, called Borexino. An event reconstruction technique using charge and time data from the PMTs is analyzed using the obtained relations in order to improve the detector resolution. Algorithms for the energy and coordinates reconstruction of events are presented
Scattering Equations and Factorization of Amplitudes II: Effective Field Theories
Creators: name: Gomez, Humberto
name: Helset, Andreas
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We continue the program of extending the scattering equation framework by Cachazo, He and Yuan to a double-cover prescription. We discuss how to apply the double-cover formalism to effective field theories, with a special focus on the non-linear sigma model. A defining characteristic of the double-cover formulation is the emergence of new factorization relations. We present several factorization relations, along with a novel recursion relation. Using the recursion relation and a new prescription for the integrand, any non-linear sigma model amplitude can be expressed in terms of off-shell three-point amplitudes. The resulting expression is purely algebraic, and we do not have to solve any scattering equation. We also discuss soft limits, boundary terms in BCFW recursion, and application of the double-cover prescription to other effective field theories, like the special Galileon theory.
description: 39+14 pages
Incident Substance Use Disorder Following Anxiety Disorder in Privately Insured Youth
Creators: name: Olfson, M.
name: Bushnell, G.A.
name: Compton, S.N.
name: Dusetzina, S.B.
name: Gaynes, B.N.
name: Stürmer, T.
Publisher: name: Elsevier USA
Year: 2019

description: Purpose: Anxiety disorders in childhood might be associated with an increased risk of substance use disorders. Incident substance use–related diagnoses were quantified in the 2 years after youth were newly diagnosed with an anxiety disorder and in a similar cohort of youth without diagnosed anxiety. Methods: Privately insured youth (10–17 years) were identified in a commercial claims database who were newly diagnosed with an anxiety disorder (2005–2014), treatment naïve, and without baseline substance-related disorder diagnoses. The comparison cohort included age, sex, region, and date matched youth with equivalent baseline exclusions. We used Kaplan–Meier estimator to calculate 2-year cumulative incidence of substance use disorder diagnosis following a new office-based anxiety disorder diagnosis (or match date for comparison cohort). Results: In 131,271 youth with a new anxiety disorder diagnosis (male = 41%, median age = 14 years), 1.5% (95% confidence interval = 1.5–1.6) had an incident substance use disorder diagnosis 1 year after their anxiety diagnosis, 2.9% (95% confidence interval = 2.8–3.0) by 2 years. Over the same period, .5% and 1.1% of the comparison cohort had incident substance use disorder diagnoses (n = 1,321,701). In the anxiety cohort, 2-year incidence was higher in youth aged 14–17 years (4.6%) versus 10–13 years (.7%). Incidence of substance use diagnosis varied by anxiety disorder (e.g., 2-year incidence: 4.3% for post-traumatic stress disorder, 3.0% for generalized anxiety disorder). Conclusion: Approximately 3% of youth newly diagnosed with anxiety received an incident substance use disorder diagnosis within 2 years, almost threefold the incidence in youth without an anxiety diagnosis, emphasizing the need for increased awareness and prevention of substance-related disorders in pediatric anxiety.
SOS vs. MAD
Creators: name: Costa Macedo, Pedro Adélio
Publisher: name: Zenodo
Year: 2017

description: Recensão crítica da obra “The Safe Operating Space Treaty - A New Approach to Managing Our Use of the Earth System”, Eds. Magalhães, P., Steffen, W., Bosselmann, K., Aragão, A., & Marques, V. S. (2016). Newcastle upon Tyne, UK: Cambridge Scholars Publishing. 309 pp. ISBN 978-1-4438-8903-2
title: Application of lower Punch Vibration to improve the mechanical Stability of Tablets
Creators: name: Kalies, Alexander
name: Heinrich, Thomas
name: Leopold, Claudia
Publisher: name: Universitätsbibliothek Braunschweig
Year: 2020
Subjects: subject: Tableting, lower punch vibration, mechanical stability, lamination
subject: 615.19
subject: 660

description: A sufficient mechanical stability of tablets to be compacted prevents problems during tableting (e.g. sticking, capping,
lamination) and is crucial with regard to further processing steps such as coating or packaging. Often, an improvement of
the mechanical stability is only achievable by an adaption of the production settings (die disk speed) or an alteration of
the powder blend composition. In the present study, a novel lower punch vibration device was developed and implemented
on a rotary tablet press to improve the mechanical stability of the resulting tablets without changing the production
conditions or the powder formulation. Various types of microcrystalline cellulose with different physical properties were
selected. The powders were investigated concerning their powder flow, density, particle morphology and surface area and
the tablets concerning their weight, tensile strength, and capping index. The results showed that externally applied lower
punch vibration improved the mechanical stability of the investigated tablets beyond the adaption of the production
settingss and the physical properties of the powder blend.
description: SPhERe Proceedings: 3rd International Symposium on Pharmaceutical Engineering Research
Brevipalpus yothersi Baker 1949
Creators: name: Sinico, Thaís Elise
name: Nunes, Maria Andréia
name: Kitajima, Elliot Watanabe
name: Cunha, Bruna Aparecida
name: Novelli, Valdenice Moreira
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Tenuipalpidae
Brevipalpus
Brevipalpus yothersi

description: Brevipalpus yothersi egg morphology
Details of external eggs morphology could be followed under SEM. Transverse streaks in the outer layer of the eggs called carenas (Rodrigues and Machado 1999) (Figure 2a) and a fold-like structure in the equatorial region of the egg (Figure 2b). An external globular structure were observed in studies by Rodrigues and Machado (1999). However, it was observed only in eggs with a more advanced development time but morphologically different from the one found in our study.
 Eggshells frequently broke during fixation in Carnoy’s solution, allowing for observation of the internal structure of eggs. Additionally, channels similar to small perforations were seen extending between the shell and intermediate lamella (Figure 3). These channels may be associated with the respiratory tract of the embryo. Such structures were also observed by Dittrich (1971) in studies with T. urticae, and they have been shown to give mites protection against desiccation and gas exchange.
description: Published as part of Sinico, Thaís Elise, Nunes, Maria Andréia, Kitajima, Elliot Watanabe, Cunha, Bruna Aparecida & Novelli, Valdenice Moreira, 2022, Notes on the embryological development of the Brevipalpus yothersi (Acari: Tenuipalpidae), pp. 113-119 in Acarologia 62 (1) on page 116, DOI: 10.24349/0gr3-3a6b, http://zenodo.org/record/7160131
Search for dark matter produced in association with a pair of bottom quarks in proton-proton collisions at $\sqrt{s}$ = 13 TeV
Creators: name: CMS Collaboration
Publisher: name: arXiv
Year: 2024
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: A search for dark matter (DM) particles produced in association with bottom quarks is presented. The analysis uses proton-proton collision data at a center-of-mass energy of $\sqrt{s}$ = 13 TeV, corresponding to an integrated luminosity of 138 fb$^{-1}$. The search is performed in the final state with large missing transverse momentum and a pair of jets originating from bottom quarks. No significant excess of data is observed with respect to the standard model expectation. Results are interpreted in the context of a type-II two-Higgs-doublet model with an additional light pseudoscalar (2HDM+a). An upper limit is set on the mass of the lighter pseudoscalar, excluding masses up to 260 GeV at 95% confidence level. Sensitivity to the parameter space with the ratio of the vacuum expectation values of the two Higgs doublets, $\tanβ$, greater than 15 is achieved, capitalizing on the enhancement of couplings between pseudoscalars and bottom quarks with high $\tanβ$.
description: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at http://cms-results.web.cern.ch/cms-results/public-results/publications/SUS-23-008 (CMS Public Pages)
Robustness as an Evolutionary Principle
Creators: name: Bornholdt, Stefan
name: Sneppen, Kim
Publisher: name: arXiv
Year: 2000
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: Biological Physics (physics.bio-ph)
subject: Molecular Networks (q-bio.MN)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: We suggest to simulate evolution of complex organisms constrained by the sole requirement of robustness in their expression patterns. This scenario is illustrated by evolving discrete logical networks with epigenetic properties. Evidence for dynamical features in the evolved networks is found that can be related to biological observables.
description: 5 pages RevTeX, 4 figures PostScript, submitted to Proc R. Soc. London B
Doppler-Shifted Alkali D Absorption as Indirect Evidence for Exomoons
Creators: name: Schmidt, Carl
Publisher: name: arXiv
Year: 2022
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Sodium and potassium signatures in transiting exoplanets can be challenging to isolate from the stellar absorption lines. Here, these challenges are discussed in the framework of Solar System observations, and transits of Mercury in particular. Radiation pressure is important for alkali gas dynamics in close-orbiting exoplanets since the D lines are efficient at resonant scattering. When the star-planet velocity is >10km/s, eccentric exoplanets experience more than an order of magnitude higher radiation pressures, aiding atmospheric escape and producing a larger effective cross-section for absorbing starlight at the phase of transit. The Doppler shift also aids in isolating the planetary signature from the stellar photosphere's absorption. Only one transiting exoplanet, HD 80606b, is presently thought to have both this requisite Doppler shift and alkali absorption. Radiation pressure on a planetary exosphere naturally produces blue-shifted absorption, but at levels insufficient to account for the extreme Doppler shifts that have been inferred from potassium transit measurements of this system. In the absence of clear mechanisms to generate such a strong wind, it is described how this characteristic could arise from an exomoon-magnetosphere interaction, analogous to Io-Jupiter. At low contrasts presented here, follow-up transit spectra of HD 80606b cannot rule out a potassium jet or atmospheric species with a broad absorption structure. However, it is evident that line absorption within the imaging passbands fails to explain the narrow-band photometry that has been reported in-transit. New observations of energetic alkalis produced by the Io-Jupiter interaction are also presented, which illustrate that energetic sodium Doppler structure offers a more valuable marker for the presence of an exomoon than potassium.
description: 15 pages, 4 Figures, Frontiers in Astronomy and Space Sciences, Accepted 28 Feb 2022
title: Engineering Yeast for Production of Benzophenones and Xanthones as Precursors of Polycyclic Polyprenylated Acylphloroglucinols
Creators: name: Liu, Benye
name: Kalz, Lars
name: Jia, Yizhen
name: Grull, Marco
name: Beuerle, Till
name: Beerhues, Ludger
Publisher: name: Universitätsbibliothek Braunschweig
Year: 2020
Subjects: subject: benzophenone, xanthone, yeast, prenyltransferase, synthetic biology
subject: 615.19
subject: 660

description: Polycyclic polyprenylated acylphloroglucinols (PPAPs) exhibit a broad range of biological activities, such as
antidepressant, antibacterial, antiviral and antitumor properties. The content of PPAPs in the producing plants is often
quite low, and their complex structures make total chemical synthesis difficult and economically impractical. Progresses
in synthetic biology provide an alternative approach for the production of these valuable compounds. Here we present
our results on reconstruction of the biosynthetic pathways of PPAP precursors in yeast. Based on our previous works on
the biosynthesis of PPAPs, genes involved in the formation of benzophenones and xanthones from Hypericum sp. and
other organisms were expressed in yeast either episomally or by integration into the genome. The production of the
expected products reached around 0.5 mg/l, which is high enough to be the substrate for enzymes of subsequent
biosynthetic steps. The yeast strains will be further engineered by introducing various prenyltransferase enzymes to
reconstruct the full biosynthetic pathways of PPAPs.
description: SPhERe Proceedings: 3rd International Symposium on Pharmaceutical Engineering Research
Psychotherapy claims surrounding pharmacotherapy initiation in children and adolescents with anxiety disorders
Creators: name: Brookhart, M.A.
name: Dusetzina, S.B.
name: Compton, S.N.
name: Gaynes, B.N.
name: Stürmer, T.
name: Bushnell, G.A.
Publisher: name: Mary Ann Liebert Inc.
Year: 2019

description: Objectives: Psychotherapy is an effective, recommended treatment for pediatric anxiety disorders. Nevertheless, individuals with mental health conditions often do not receive psychotherapy, with variation across provider types. This study sought to examine psychotherapy claims surrounding medication initiation in U.S. children with diagnosed anxiety disorders. Methods: The study cohort included privately insured children (3-17 years) with a diagnosed anxiety disorder initiating a medication to treat anxiety from 2004 to 2014. We examined psychotherapy claims in the 3 months before and 3 months after medication initiation and described children with multiple (2+) psychotherapy claims per 3-month period. Results: Of the 75,024 children initiating a medication for anxiety (median age = 14 years, 58% female), 35% had multiple psychotherapy claims before medication initiation, with variation by age, anxiety disorder, and psychiatric comorbidity and with little change across time. Psychotherapy claims after medication initiation varied by whether the child had prior psychotherapy: 80% in children with prior psychotherapy and 30% in children without prior psychotherapy claims (44% of children diagnosed by a psychiatrist, 21% of children diagnosed by a pediatrician). Conclusion: Many privately insured children do not have claims for psychotherapy before or after pharmacotherapy initiation for anxiety. Findings can inform future research and efforts to ultimately increase appropriate psychotherapy utilization in children with anxiety disorders.
Exploring the Long-Term Damaging Effects of Coercive Manipulation and Verbal Abuse
Creators: name: Dequina, Jezreel
Publisher: name: Zenodo
Year: 2025

description: This paper explores the long-term psychological and neurological effects of coercive manipulation tactics, particularly those resembling MK-Ultra-adjacent strategies and common patterns in emotional domestic violence. Without the use of substances or pharmacological agents, psychological conditioning methods such as gaslighting, emotional flooding, moral inversion, and trauma bonding are shown to produce chronic cognitive disruption, identity fragmentation, and loss of moral autonomy[1][2][3]. Through trauma theory, neuroscience, and survivor-informed analysis, this paper identifies key zones of psychological impact and calls for renewed ethical recognition of emotional manipulation as a form of psychological torture, Jezreel Dequina (2025)
Excess deaths attributable to influenza-like illness in the ESRD population
Creators: name: Chertow, G.M.
name: Ashfaq, A.
name: Collins, A.J.
name: Wetmore, J.B.
name: Winkelmayer, W.C.
name: Brookhart, M.A.
name: Herzog, C.A.
name: Gilbertson, D.T.
name: Bradbury, B.D.
name: Stürmer, T.
name: Rothman, K.J.
name: Liu, J.
name: Monda, K.L.
Publisher: name: American Society of Nephrology
Year: 2019

description: Background Morbidity and mortality vary seasonally. Timing and severity of influenza seasons contribute to those patterns, especially among vulnerable populations such as patients with ESRD. However, the extent to which influenza-like illness (ILI), a syndrome comprising a range of potentially serious respiratory tract infections, contributes to mortality in patients with ESRD has not been quantified. Methods We used data from the Centers for Disease Control and Prevention (CDC) Outpatient Influenzalike Illness Surveillance Network and Centers for Medicare and Medicaid Services ESRD death data from 2000 to 2013. After addressing the increasing trend in deaths due to the growing prevalent ESRD population, we calculated quarterly relative mortality compared with average third-quarter (summer) death counts. We used linear regression models to assess the relationship between ILI data and mortality, separately for quarters 4 and 1 for each influenza season, and model parameter estimates to predict seasonal mortality counts and calculate excess ILI-associated deaths. Results An estimated 1% absolute increase in quarterly ILI was associated with a 1.5% increase in relative mortality for quarter 4 and a 2.0% increase for quarter 1. The average number of annual deaths potentially attributable to ILI was substantial, about 1100 deaths per year. Conclusions We found an association between community ILI activity and seasonal variation in all-cause mortality in patients with ESRD, with ILI likely contributing to .1000 deaths annually. Surveillance efforts, such as timely reporting to the CDC of ILI activity within dialysis units during influenza season, may help focus attention on high-risk periods for this vulnerable population.
title: The extended Elution by characteristic Point Method to determine Adsorption Isotherms of Labyrinthopeptin for Purification via Ion-Exchange Chromatography
Creators: name: Lohr, Jonas
name: Hartig, Dave
name: Scholl, Stephan
name: Spieß, Antje
Publisher: name: Universitätsbibliothek Braunschweig
Year: 2020
Subjects: subject: Adsorption isotherm, Elution by Characteristic Point, Ion-Exchange Chromatography, Labyrinthopeptin
subject: 615.19
subject: 660

description: Ion-exchange chromatography (IEC) is the most frequently used technique to purify proteins and therefore, plays an
important role in process development for therapeutical proteins. To improve the purification using ion-exchange
chromatography, adequate characterization of adsorption isotherms is obligatory. The Elution by Characteristic Point
method (ECP) can be used to determine adsorption isotherms applying only minor amounts of sample material to the
chromatography column. Here, the applicability of the extended ECP method to determine adsorption isotherms of the
model protein bovine serum albumin (BSA) using bovine hemoglobin (bHb) as tracer substance to quantify all nonidealities
of the system is shown. The resulting isotherm was validated using the static batch approach. In the next step,
the gained knowledge is used to measure isotherms of Labyrinthopeptins A1 and A2, which show promising activity
against retroviruses like herpes simplex virus or human immunodeficiency virus.
description: SPhERe Proceedings: 3rd International Symposium on Pharmaceutical Engineering Research
Topological phases of non-symmorphic crystals : Shastry-Sutherland lattice at integer filling
Creators: name: Yang, Hyeok-Jun
name: Lee, SungBin
Publisher: name: arXiv
Year: 2018
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Motivated by intertwined crystal symmetries and topological phases, we study the possible realization of topological insulator in nonsymmorphic crystals at integer fillings. In particular, we consider spin orbit coupled electronic systems of two-dimensional crystal Shastry-Sutherland lattice at integer filling where the gapless line degeneracy is protected by glide reflection symmetry. Based on a simple tight-binding model, we investigate how the topological insulating phase is stabilized by breaking nonsymmorphic symmetries but in the presence of time reversal symmetry and inversion symmetry. In addition, we also discuss the regime where Dirac semimetal is stabilized, having non trivial $Z_2$ invariants even without spin orbit coupling (SOC). Our study can be extended to more general cases where all lattice symmetries are broken and we also discuss possible application to topological Kondo insulators in nonsymmorphic crystals where crystal symmetries can be spontaneously broken as a function of Kondo coupling.
description: 6 pages, 4 figures
Results: Preliminary experiments with the Andean Condor Algorithm to Solve Problems of Continuous Domains
Creators: name: Almonacid, Boris
Publisher: name: figshare
Year: 2019
Subjects: subject: 10303 Optimisation
subject: FOS: Mathematics

description: Results of the experiment performed when using the Andean Condor Algorithm in a continuous domain function.
Dipolar fluence distribution of statistically isotropic FERMI gamma-ray bursts
Creators: name: Lopes, Maria
name: Bernui, Armando
name: Hipólito-Ricaldi, Wiliam S.
name: Franco, Camila
name: Avila, Felipe
Publisher: name: arXiv
Year: 2024
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We investigated the large-angle distribution of the gamma-ray bursts (GRBs) from the updated FERMI/GBM catalog to probe the statistical isotropy of these astrophysical transient events. We also studied the angular distribution of the GRB fluence as a way to explore whether this radiative feature shows some preferred direction on the sky that suggest their origin. Our model-independent approach performed a directional analysis of the updated FERMI/GBM catalog. The statistical significance of our results is obtained by comparison with a large set of statistically isotropic samples of cosmic objects, with the same features of the FERMI data. Our analyses confirm that the angular distribution of the FERMIGRB is statistically isotropic on the celestial sphere. Moreover, analyzing the directional distribution of the FERMIGRB fluence, that is, the median GRB fluence in a set of directions that scans the celestial sphere, we found that this astrophysical property exhibits a net dipolar structure with a directional preference for latitudes near the Galactic plane. However, additional studies show that this directional preference is not correlated with the Milky Way Galactic plane, which suggests that the GRB dataset, and its fluence dipolar structure, are extra-Galactic in origin. Interestingly, the analyses of the BATSE Channel 4 fluence data, that is, those GRBs from BATSE with energy $>$ 300 keV, reveal that its dipole direction is very well aligned with the cosmic microwave background dipole.
description: Accepted for publication in Astronomy & Astrophysics (A&A)
Wormholes and Flux Tubes in 5D Kaluza-Klein Theory
Creators: name: Dzhunushaliev, V.
name: Singleton, D.
Publisher: name: arXiv
Year: 1998
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this paper spherically symmetric solutions to 5D Kaluza-Klein theory, with ``electric'' and/or ``magnetic'' fields are investigated. It is shown that the global structure of the spacetime depends on the relation between the ``electrical'' and ``magnetic'' Kaluza-Klein fields. For small ``magnetic'' field we find a wormhole-like solution. As the strength of the ``magnetic'' field is increased relative to the strength of the ``electrical'' field, the wormhole-like solution evolves into a finite or infinite flux tube depending on the strengths of the two fields. For the large ``electric'' field case we conjecture that this solution can be considered as the mouth of a wormhole, with the $G_{55}$, $G_{5t}$ and $G_{5ϕ}$ components of the metric acting as the source of the exotic matter necessary for the formation of the wormhole's mouth. For the large ``magnetic'' field case a 5D flux tube forms, which is similar to the flux tube between two monopoles in Type-II superconductors, or the hypothesized color field flux tube between two quarks in the QCD vacuum.
description: 12 pages, 5 eps.figures, REVTEX, Discussion about null surfaces ammended. References added. To be published in PRD
Limnesia (Limnesia) ekama Cook 1986
Creators: name: Smit, Harry
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Limnesiidae
Limnesia
Limnesia ekama

description: Limnesia (Limnesia) ekama Cook, 1986
 New records — Tasmania. 1/1/0, unnamed creek at crossing of Rosendale Road, 2.5 km off Tasman Highway, Bicheno, 19 Oct. 1997 ; 0/1/0, Betka River at crossing with Stony Creek Road, SW of Genoa, 24 Oct. 1997. Victoria. 2/3/2, Aire River at Aire Crossing, Great Otway Ranges NP, 38°42.190′ S 143°28.536′ E, 202 m a.s.l., 1 Apr. 2008. New South Wales. 0/1/0, tributary of Sawyers Creek, N of Kangaroo Valley, 6 Nov. 2001. Queensland. 0/1/0, Lacey Creek, Mission Beach, 17 Sept. 2000 ; 2/2/0, Babinda River, Wooroonooran NP, 17°20.484′ S 145°52.113′ E, 16 Oct. 2005 ; 1/0/0, Tully River at campground, Tully Gorge NP, 17°46.280′ S 145°39.073′ E, 86 m a.s.l., 4 Nov. 2014.
 Distribution — Previously known from Tasmania and New South Wales (Cook 1986) and reported here for the first time from Victoria and Queensland.
description: Published as part of Smit, Harry, 2022, New records of water mites of the family Limnesiidae Thor from Australia (Acari: Hydrachnidia), with the description of seven new species, pp. 193-222 in Acarologia 62 (1) on page 196, DOI: 10.24349/yu9v-w0lf, http://zenodo.org/record/7160186
Comparison of alternative approaches to trim subjects in the tails of the propensity score distribution
Creators: name: Poole, C.
name: Rothman, K.J.
name: Lunt, M.
name: Stürmer, T.
name: Schneeweiss, S.
name: Glynn, R.J.
Publisher: name: John Wiley and Sons Ltd
Year: 2019

description: Purpose: In nonexperimental comparative effectiveness research, restricting analysis to subjects with better overlap of covariate distributions, hence greater treatment equipoise, helps balance the groups compared and can improve validity. Three alternative approaches, derived from different perspectives, implement restriction by trimming observations in the tails of the propensity score (PS). Across approaches, we compared the relationships between the overlap in treatment-specific PS distributions and the size of the balanced study population after trimming. Methods: The three trimming approaches considered were absolute trimming to the range 0.1<PS<0.9, asymmetric trimming to include subjects in both treatment groups with PS above the 5th percentile of the distribution in the target group and below the 95th percentile in the comparison group, and restriction to preference score values between 0.3 and 0.7. Comparisons of approaches used simulated PSs from beta distributions and two example studies. Results: The magnitude of the C-statistic strongly predicted (R2≥.95) the percent of the balanced study population remaining. The balanced study population was largest under trimming at absolute PS levels, unless the target treatment was uncommon. Fewer than half of original study subjects remained after preference score trimming if C≥.80 and after asymmetric trimming if C≥.85. In examples, trimming improved the precision of estimated risk differences and identified apparent treatment effect heterogeneity in the PS tails where covariate balance was limited. Relative amounts of trimming in examples reflected the simulation results. Conclusions: Study populations with high PS C-statistics include only small percentages of subjects in whom valid treatment effects are confidently expected.
title: Solvation free Energy Predictions from molecular Dynamics Simulations by improved alchemical Pathways and optimized Force Field Parameters
Creators: name: Mecklenfeld, Andreas
name: Raabe, Gabriele
Publisher: name: Universitätsbibliothek Braunschweig
Year: 2020
Subjects: subject: Molecular simulation, solvation free energy, force field optimization
subject: 615.19
subject: 660

description: The rapid development of affordable medications relies on the knowledge of suitable solvents for potential active
pharmaceutical ingredients. Molecular simulations can be interpreted as computational experiments and may complement
laboratory experiments, as they not only enable the calculation of thermophysical properties but also allow for an insight
into a systems behavior on the molecular level. Relative solubilities can be predicted by using molecular simulations to
calculate the Gibbs free energy of solvation ΔGsolv. We developed algorithms to reduce the required computational effort
and increase the statistical precision by improved alchemical pathways. However, the agreement between ΔGsolv
predictions from simulations and experimental data depends on the molecular models (force fields) used. To consider
polarization effects, we combined partial charges derived by the IPolQ-Mod method with the General Amber Force Field
(GAFF) and found a comparable ΔGsolv accuracy to GAFF and its default RESP charges for a large set of compounds in
various solvents. We initiated a parameter optimization to improve the accuracy of GAFF/IPolQ-Mod and present our
current results of the refitting process.
description: SPhERe Proceedings: 3rd International Symposium on Pharmaceutical Engineering Research
Predicting Exoplanets Mass and Radius: A Nonparametric Approach
Creators: name: Ning, Bo
name: Wolfgang, Angie
name: Ghosh, Sujit
Publisher: name: arXiv
Year: 2018
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: A fundamental endeavor in exoplanetary research is to characterize the bulk compositions of planets via measurements of their masses and radii. With future sample sizes of hundreds of planets to come from TESS and PLATO, we develop a statistical method that can flexibly yet robustly characterize these compositions empirically, via the exoplanet M-R relation. Although the M-R relation has been explored in many prior works, they mostly use a power-law model, with assumptions that are not flexible enough to capture important features in current and future M-R diagrams. To address these shortcomings, a nonparametric approach is developed using a sequence of Bernstein polynomials. We demonstrate the benefit of taking the nonparametric approach by benchmarking our findings with previous work and showing that a power-law can only reasonably describe the M-R relation of the smallest planets and that the intrinsic scatter can change non-monotonically with different values of a radius. We then apply this method to a larger dataset, consisting of all the Kepler observations in the NASA Exoplanet Archive. Our nonparametric approach provides a tool to estimate the M-R relation by incorporating heteroskedastic measurement errors into the model. As more observations will be obtained in the near future, this approach can be used with the provided R code to analyze a larger dataset for a better understanding of the M-R relation.
description: 20 pages, 13 figures
A Stress Tensor for Anti-de Sitter Gravity
Creators: name: Balasubramanian, Vijay
name: Kraus, Per
Publisher: name: arXiv
Year: 1999
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We propose a procedure for computing the boundary stress tensor associated with a gravitating system in asymptotically anti-de Sitter space. Our definition is free of ambiguities encountered by previous attempts, and correctly reproduces the masses and angular momenta of various spacetimes. Via the AdS/CFT correspondence, our classical result is interpretable as the expectation value of the stress tensor in a quantum conformal field theory. We demonstrate that the conformal anomalies in two and four dimensions are recovered. The two dimensional stress tensor transforms with a Schwarzian derivative and the expected central charge. We also find a nonzero ground state energy for global AdS_5, and show that it exactly matches the Casimir energy of the dual N=4 super Yang-Mills theory on S^3 x R.
description: 19 pages. added footnote, reference
title: Hydrogels based on polymerized ionic Liquids as innovative Drug Carriers in controllable and individualized Dosage Forms
Creators: name: Mildner, Andrea
name: Henke, Laurids
name: Gerdes, T.
name: Großeheilmann, Julia
Publisher: name: Universitätsbibliothek Braunschweig
Year: 2020
Subjects: subject: Hydrogel, Polymerized Ionic Liquids, Drug Delivery
subject: 615.19
subject: 660

description: Novel Polymerized Ionic Liquids (PILs)-based Hydrogels as Innovative Drug Delivery Systems are presented. The
embedding of drugs in hydrogels enables the “smart” delivery of bioactive molecules from drugs for an oral route of
administration. Therefore, a high mechanical strength as well as a favorable pH-dependent swelling behavior is required
which is shown in this study. A mechanical compression of PILs-based hydrogels up to 98.5% and a high swelling
behavior of poly(VEImBr) hydrogels in a solution with a high pH value is achieved. A significant lower swelling is
achieved in a solution with a lower pH value.
description: SPhERe Proceedings: 3rd International Symposium on Pharmaceutical Engineering Research
Cork oak stands understory management: impacts on the soil - Gestão do subcoberto em Montado: impactos no solo
Creators: name: Felizardo, Ana Raquel
Publisher: name: Zenodo
Year: 2019
Subjects: RAIN
cork oak trees
Portugal
farmer
stakeholder
agroforestry
pasture
fodder
organic matter content
nutrients
Sobreiro
cortiça
agricultor
partes interessadas
sistemas agroflorestais
pastagens
forragens
conteúdo em matéria orgânica
nutriente

description: Presentation on the 5th Portuguese RAIN meeting
Efficient magnetohydrodynamic modelling of the time-evolving corona by COCONUT
Creators: name: Wang, Haopeng
name: Poedts, Stefaan
name: Lani, Andrea
name: Brchnelová, Michaela
name: Baratashvili, Tinatin
name: Linan, Luis
name: Zhang, Fan
name: Hou, Dawei
name: Zhou, Yuhao
Publisher: name: arXiv
Year: 2024
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: Compared to quasi-steady-state corona models that are constrained by a time-invariant magnetogram over a CR period, time-evolving corona models driven by time-varying photospheric magnetograms are more realistic and can maintain more useful information to accurately describe solar wind evolution and forecast CME propagation. This paper demonstrate that time-evolving corona simulations can be performed efficiently and accurately using an implicit method with relatively large time steps. We also evaluate differences between coronal structures captured by time-evolving and quasi-steady simulations over a CR period during solar minimum. We used a series of hourly updated photospheric magnetograms to drive the evolution of coronal structures from the solar surface to $25\; R_s$ during two CRs around the 2019 eclipse in an inertial coordinate system. We compare the time-evolving and quasi-steady simulations to demonstrate that the differences in these two types of coronal modelling can be obvious even for a solar minimum. The relative differences in radial velocity and density can be over $15 \%$ and $25 \%$ at 20$\;R_s$ during one CR period. We also evaluated the impact of time steps on the simulation results. Using a time step of approximately 10 minutes balances efficiency and necessary numerical stability and accuracy for time-evolving corona simulations around solar minima, with coronal evolution during a full CR simulated within only 9 hours (using 1080 CPU cores for 1.5M grid cells). The simulation results demonstrate that time-evolving MHD coronal simulations can be performed efficiently and accurately using an implicit method, offering a more realistic alternative to quasi-steady-state simulations. The fully implicit time-evolving corona model thus promises to simulate the time-evolving corona accurately in practical space weather forecasting.
description: accept, 14 pages, 7 figures, 4 movies
title: Characterisation of Water Uptake and swelling Force of pharmaceutical Tablets
Creators: name: Puckhaber, Daniel
name: Finke, Jan
name: Lange, Lennart
name: Juhnke, Michael
name: John, Edgar
name: Kwade, Arno
Publisher: name: Universitätsbibliothek Braunschweig
Year: 2020
Subjects: subject: Water uptake, swelling force, tablets, disintegrants
subject: 615.19
subject: 660

description: Tablets are the most common dosage form in the pharmaceutical industry. Rapid drug release is ensured by quick tablet
disintegration which is caused by the absorption of water into the tablet. Therefore, water uptake and subsequent volume
expansion are necessary requirements for tablet disintegration. In this work, binary mixtures of excipients were compacted
to tablets with varying structural and mechanical properties to determine the influence of formulation and process
parameters on water uptake and resulting swelling force of tablets. Results showed strong influences of disintegrant
concentration as well as tablet porosity on both absorbed amount of water and acting swelling force. Obtained results
revealed that water uptake and swelling force measurements are useful tools for an improved understanding of tablet
disintegration.
description: SPhERe Proceedings: 3rd International Symposium on Pharmaceutical Engineering Research
Nonthermal radiation from clusters of galaxies: the role of merger shocks in particle acceleration
Creators: name: Gabici, Stefano
name: Blasi, Pasquale
Publisher: name: arXiv
Year: 2002
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Nonthermal radiation is observed from clusters of galaxies in the radio, hard X-rays, and possibly in the soft X-ray/UV bands. While it is known that radiative processes related to nonthermal electrons are responsible for this radiation, the sites and nature of particle acceleration are not known. We investigate here the acceleration of protons and electrons in the shocks originated during mergers of clusters of galaxies, where the Fermi acceleration may work. We propose a semi-analytical model to evaluate the Mach number of the shocks generated during clusters mergers and we use this procedure to determine the spectrum of the accelerated particles for each one of the shocks produced during the merger history of a cluster. We follow the proton component, accumulated over cosmological time scales, and the short lived electron component. We conclude that efficient particle acceleration, resulting in nonthermal spectra that compare to observations, occurs mainly in minor mergers, namely mergers between clusters with very different masses. Major mergers, often invoked to be sites for the production of extended radio halos, are found to have on average too weak shocks and are unlikely to result in appreciable nonthermal activity.
description: Version accepted for publication in the Astrophysical Journal
Microscopic Treatment of Binary Interactions in the Non-Equilibrium Dynamics of Partially Bose-condensed Trapped Gases
Creators: name: Proukakis, N. P.
name: Burnett, K.
name: Stoof, H. T. C.
Publisher: name: arXiv
Year: 1997
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: In this paper we use microscopic arguments to derive a nonlinear Schrödinger equation for trapped Bose-condensed gases. This is made possible by considering the equations of motion of various anomalous averages. The resulting equation explicitly includes the effect of repeated binary interactions (in particular ladders) between the atoms. Moreover, under the conditions that dressing of the intermediate states of a collision can be ignored, this equation is shown to reduce to the conventional Gross-Pitaevskii equation in the pseudopotential limit. Extending the treatment, we show first how the occupation of excited (bare particle) states affects the collisions, and thus obtain the many-body T-matrix approximation in a trap. In addition, we discuss how the bare particle many-body T-matrix gets dressed by mean fields due to condensed and excited atoms. We conclude that the most commonly used version of the Gross-Pitaevskii equation can only be put on a microscopic basis for a restrictive range of conditions. For partial condensation, we need to take account of interactions between condensed and excited atoms, which, in a consistent formulation, should also be expressed in terms of the many-body T-matrix. This can be achieved by considering fluctuations around the condensate mean field beyond those included in the conventional finite temperature mean field, i.e. Hartree-Fock-Bogoliubov (HFB), theory.
description: Resolved some problems with printing of figures