cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Micro Combined Heat and Power Units in the UK: Feasibility Assessment Using Real Time Pricing and Analysis of Related Policies
Creators: name: Sudtharalingam, Sohasini
Publisher: name: Imperial College London
Year: 2012

description: This thesis considers the techno-economic feasibility of micro combine heat and power (micro-CHP) units within individual dwellings. A cost-minimisation unit-commitment control strategy is applied so that units are operated in their most advantageous fashion in various scenarios. A variety of dwelling types and energy needs were modelled (with data from the Carbon Trust field trial) and a set of sample days chosen to represent seasonal changes. Four different micro-CHP technologies were examined and thermal storage and auxiliary heating considered. The objective was to establish whether a possible introduction of Real Time Pricing (RTP) of energy would affect the viability of micro-CHP and to establish which, if any, support mechanisms might be appropriate. The results show that fuel cell micro-CHPs out-performed the engine-based micro- CHP in most aspects. Low heat to electricity ratio is a desired characteristic given that the electricity price is typically significantly higher than that of gas and a higher production of on-site electricity is favourable. The results show that significant reduction in energy bills (electricity and gas) are possible under RTP compared to fixed tariffs but, in most cases, are not sufficient to cover the capital costs of the micro-CHP. Adoption of micro-CHP becomes tenable when financial incentives such as capital grants and operational cost support (such as Feed in Tariffs, FiT) exist. The results show FiT to be effective from both the consumers’ and a government’s points of view. However, operational cost support alone might not be sufficient to encourage uptake of micro-CHPs and therefore a loan scheme, which supports the initial cost, should be implemented in parallel. A study of CO2 emissions showed that the extent emissions reduction contributed by micro-CHPs is strongly dependent on the type of micro-CHP used and somewhat less influenced by the price of energy.
Additional file 4 of A robust cell culture system for large scale feeder cell-free expansion of human breast epithelial progenitors
Creators: name: Sumanta Chatterjee
name: Basak, Pratima
name: Buchel, Edward
name: Murphy, Leigh
name: Raouf, Afshin
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Supplementary methods. (PDF 93 kb)
Basins of convergence in the circular Sitnikov four-body problem with non-spherical primaries
Creators: name: Zotos, Euaggelos E.
name: Satya, Satyendra Kumar
name: Aggarwal, Rajiv
name: Suraj, Md Sanam
Publisher: name: arXiv
Year: 2018
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: The Newton-Raphson basins of convergence, related to the equilibrium points, in the Sitnikov four-body problem with non-spherical primaries are numerically investigated. We monitor the parametric evolution of the positions of the roots, as a function of the oblateness coefficient. The classical Newton-Raphson optimal method is used for revealing the basins of convergence, by classifying dense grids of initial conditions in several types of two-dimensional planes. We perform a systematic and thorough analysis in an attempt to understand how the oblateness coefficient affects the geometry as well as the basin entropy of the convergence regions. The convergence areas are related with the required number of iterations and also with the corresponding probability distributions.
description: Published in International Journal of Bifurcation and Chaos (IJBC) journal
Non-Commutative Moduli Spaces, Dielectric Tori and T-duality
Creators: name: Berenstein, David
name: Jejjala, Vishnu
name: Leigh, Robert G.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We review and extend recent work on the application of the non-commutative geometric framework to an interpretation of the moduli space of vacua of certain deformations of N=4 super Yang-Mills theories. We present a simple worldsheet calculation that reproduces the field theory results and sheds some light on the dynamics of the D-brane bubbles. Different regions of moduli space are associated with D5-branes of various topologies; singularities in the moduli space are associated with topology change. T-duality on toroidal topologies maps between mirror string realizations of the field theory.
description: published version: a few clarifications, a new figure and a new title
title: ADCO, Comptes du Petit-Cîteaux (1477-1491) (11 H 1179), f. 00231
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Archives Départementales De La Côte D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: comptes
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Comptes du Petit-Cîteaux (1477-1491), Archives départementales de la Côte-d'Or, (11 H 1179). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Comptes du Petit-Cîteaux (1477-1491), Archives départementales de la Côte-d'Or, (11 H 1179), f. 00231, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Iron Kalpha line widths in magnetic cataclysmic variables
Creators: name: Hellier, Coel
name: Mukai, Koji
name: Osborne, J. P.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Following a recent report that AO Psc has broad iron Kalpha emission lines we have looked at the ASCA spectra of 15 magnetic cataclysmic variables. We find that half of the systems have Kalpha lines broadened by ~200 eV, while the remainder have narrow lines. We argue that the Doppler effect is insufficient to explain the finding and propose that the lines originate in accretion columns on the verge of optical thickness, where Compton scattering of resonantly-trapped line photons broadens the profile. We suggest that the broadening is a valuable diagnostic of conditions in the accretion column.
description: 5 pages, 1 figure, LaTeX, To appear in MNRAS. Also at http://www.astro.keele.ac.uk/~ch/
Meat fatty acids profile including metabolic, qualitative, nutritional indices, and organoleptic evaluation as affected by Rumex nervosus leaves meal fortified broiler diets
Creators: name: Qaid, Mohammed M.
name: Al-Mufarrej, Saud I.
name: Al-Garadi, Maged A.
name: Al-Abdullatif, Abdulaziz A.
name: Alqhtani, Abdulmohsen H.
name: Alhotan, Rashed A.
name: Alharthi, Abdulrahman S.
name: BaZeyad, Abdulgader Y.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Science Policy

description: The effects of dietary supplementation with Rumex nervosus leaves (RNL) on fatty acid (FAs) indices, organoleptic evaluation, performance index, and feed efficiency were investigated. This study consists of five treatments. Broilers in treatments 1–4 received basal feed plus RNL at doses of 0, 1, 3, and 5 g/kg, while broilers in treatment 5 received basal feed plus the antibiotic Colimex. On day 34, FAs profile and organoleptic assessment were evaluated, and performance index and feed efficiency were determined for the entire experimental period. Results showed that FAs profile of the breast meat was affected by treatments with varying degrees (p˂0.05). The 1 g RNL resulted in the highest eicosapentaenoic acid + docosahexaenoic acid, which resulted in the highest meat lipid quality, the highest elongation index, improved organoleptic characteristics, and tended to improve performance index, feed efficiency, and nutritional index. The 5 g RNL treatment reduced total saturated fatty acids (ƩSFAs), omega-6/omega-3 ratio, especially linoleic acid/α-linolenic acid ratio, alanine aminotransferase, and increased total omega-3 fatty acids, unsaturation index, and Δ9-desaturase. In conclusion, RNL can be introduced to broiler diets, especially at an incorporation rate of 1 g, and it promotes broiler health and performance because it contains phytoconstituents that can alter the content and indices of FAs meat and improve storability and sensory quality. Oxidative chemicals increase lipid peroxidation and decrease sensory quality of broiler meat. As antioxidants, natural RNL inhibit oxidative degradation and prevent lipid peroxidation. RNL contains phytoconstituents that increase the fatty acid content and oxidative stability of meat. Fat deposition and associated markers in breast meat differed between low and high RNL levels. RNL improved nutritional index, sensory quality, performance index, and feed efficiency.
On the manifestations of particles
Creators: name: Buchholz, Detlev
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The mathematical description of stable particle-like systems appearing in relativistic quantum field theory at large, respectively small scales or non-zero temperatures is discussed.
description: 28 pages, latex; This paper has already appeared in "Mathematical Physics Towards the 21st Century", R. Sen, A. Gersten eds. Beer-Sheva, Ben Gurion University Press 1994
Development of an Apparatus for a Strontium Optical Lattice Optical Frequency Standard
Creators: name: Hill, Ian Robert
Publisher: name: Imperial College London
Year: 2012

description: Accurate time keeping is critical to the function and advancement of many human endeavours. Atomic clocks based on a microwave transition in atomic Cs have served as primary frequency standards to realise the SI second since their formal adoption in 1967. State-of-the-art, laser cooled, Cs fountains now routinely operate with fractional frequency uncertainties below the 10⁻¹⁵ level in laboratories throughout the world. Over the last decade, efforts to build frequency standards based on optical transitions have come to fruition and potential inaccuracies below the 10⁻¹⁷ level have been demonstrated. Such standards point to the future of time keeping and much development is being pursued to realise the potential of these 'next generation' optical clocks. One such approach, on which this work focusses, relies on a 'magic' wavelength optical lattice trap to provide (almost) Doppler- and recoil-free confinement of atoms during clock interrogation. At this 'magic' wavelength, light induced perturbation of the clock states is equal and so cancels precisely. This thesis describes the design and implementation of an optical lattice frequency standard apparatus based on 88Sr held in a 1D optical lattice. A review of the development of atomic frequency metrology is given from a historical viewpoint and the technology and limitations of current methods discussed. To tackle the blackbody radiation shift, which currently presents the greatest limitation to the Sr lattice clock, imposing at the 10⁻¹⁶ level, a scheme to measure the blackbody radiation shift coefficient at the 10⁻¹⁷ level is developed. Techniques to laser cool and trap atomic strontium are described and the implementation detailed. All laser systems required for clock operation are described including the design and implementation of extended-cavity diode lasers for precision spectroscopy. Details relevant to the eventual operation of the apparatus are discussed.
BANYAN. XIII. A First Look at Nearby Young Associations with Gaia Data Release 2
Creators: name: Gagné, Jonathan
name: Faherty, Jacqueline K.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: In this paper we examine the nearest 100 pc entries in the data release 2 of Gaia to identify previously unrecognized candidate members in young associations. We analyze 695 952 stars with the BANYAN Σ Bayesian classification software and discover 898 new high-likelihood candidate members that span a wide range in properties, from spectral types B9 to L2, including 104 co-moving systems, 111 brown dwarfs and 31 new bona fide members. Our sample is mostly composed of highly active M dwarfs and will be crucial to examine the low-mass end of the initial mass function of young associations. Our sample includes new candidate members near the Galactic plane where previous surveys suffered from a high rate of contamination. This paper represents the first step towards a full reassessment of young associations in the Solar neighborhood with the second data release of the Gaia mission.
description: Accepted for publication in ApJ. 45 pages, 5 tables, 14 figures
Additional file 2: of Multiple paralogues of α-SNAP in Giardia lamblia exhibit independent subcellular localization and redistribution during encystation and stress
Creators: name: Shankari Datta
name: Kuladip Jana
name: Avisek Mondal
name: Sandipan Ganguly
name: Srimonti Sarkar
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Table S1. α-SNAP orthologues throughout the eukaryotes. Table S2. γ-SNAP orthologues throughout the eukaryotes. Table S3. SNARE binding residues of bovine α-SNAP and residues at analogous positions on Sec17 and giardial SNAPs. Table S4. Primer sequences. Table S5. List of constructs. Table S6. Percentage of cells exhibiting relocalization of the various α-SNAPs in different stages of encystation. Table S7. Percentage of cells exhibiting relocalization of the various α-SNAPs under oxidative stress. (DOCX 43 kb)
The development and applications of a new liquid handling device
Creators: name: Shaw Stewart, Patrick
Publisher: name: Imperial College London
Year: 1988

description: This thesis describes the development of a new device for carrying out liquid chemical reactions on a very small scale, and its application to a number of problems in the biological sciences including clinical biochemistry, cell manipulation and crystallography. The device operates by containing all reactants as droplets in an inert immiscible liquid, all within a system of conduits. By moving the immiscible liquid, droplets can be dispersed, subdivided, stored or coalesced. The thesis includes a description of the device, details of the evolution of the design, and reports of experiments to test its performance. The requirements for two types of detector, bioluminescent and photometric are discussed, and preliminary experiments were performed to demonstrate their feasibility. There follows an investigation of the application of the device to clinical chemistry, especially paediatric testing. Two examples of chemical procedures to measure glucose were executed, dispensing reactants both with the device, and by other means. In order to investigate the utility of the device for handling live cells, it was demonstrated that the device could be sterilised, and operated aseptically. This opens up applications in cell fusion, and transformation in molecular biology. Preliminary experiments showed that plant cells were clearly visible within the device, and droplets containing single cells could be coalesced. It was also shown that the activity of two restriction enzymes was not significantly reduced in droplets in silicone carrier liquid. Experiments were also included to show the degree of contamination of the walls when droplets containing bacteria are moved and stored in the conduits. Moderate contamination was observed. Finally, a pilot study was conducted to investigate the utility of the device for identifying the appropriate conditions for producing crystals of newly purified proteins. This showed great promise and photographs of two proteins are shown, for which the appropriate conditions were already known. Further development of the device is also discussed in each of these areas.
Comparing the basins of attraction for several methods in the circular Sitnikov problem with spheroid primaries
Creators: name: Zotos, Euaggelos E.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: The circular Sitnikov problem, where the two primary bodies are prolate or oblate spheroids, is numerically investigated. In particular, the basins of convergence on the complex plane are revealed by using a large collection of numerical methods of several order. We consider four cases, regarding the value of the oblateness coefficient which determines the nature of the roots (attractors) of the system. For all cases we use the iterative schemes for performing a thorough and systematic classification of the nodes on the complex plane. The distribution of the iterations as well as the probability and their correlations with the corresponding basins of convergence are also discussed. Our numerical computations indicate that most of the iterative schemes provide relatively similar convergence structures on the complex plane. However, there are some numerical methods for which the corresponding basins of attraction are extremely complicated with highly fractal basin boundaries. Moreover, it is proved that the efficiency strongly varies between the numerical methods.
description: Published in Astrophysics and Space Science (A&SS) journal
On the orbital period distribution of cataclysmic variables
Creators: name: Hellier, Coel
name: Naylor, T.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Using the latest compilation of cataclysmic variable orbital periods by Ritter & Kolb we argue against Verbunt's conclusion that the period gap is not significant for nova-like variables. We also discuss the relation of the VY Scl stars to the dwarf novae.
description: 3 pages, 3 figures, LaTeX, To appear in MNRAS. Also at http://www.astro.keele.ac.uk/~ch/
Milk characteristics and milking efficiency in Italian Mediterranean buffalo
Creators: name: Matera, Roberta
name: Pascarella, Lorenzo
name: Cotticelli, Alessio
name: Conte, Giuseppe
name: Tondo, Alessia
name: Campanile, Giuseppe
name: Neglia, Gianluca
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Mental Health
subject: Virology

description: The study aimed to verify the influence of different milking machine setting parameters on Italian Mediterranean buffalo milking performance. Data on milking machine settings (Milking Dry Tests [MDTs]) and milk Test-day (TD) were collected by the Italian Breeders Association (AIA). Data for each TD consisted of milk yield (MY), fat percentage (FP), protein percentage (PP), lactose percentage (LP) and linear score (LS). Working vacuum level (VL), pulsation ratio (PR), automatic cluster removal system (AC) and effective vacuum reserve (EVR) were recorded from each MDT. A total of 558 MDTs, 217,967 TD, collected from 43,593 buffaloes in 198 buffalo farms were utilised. MDT, TD and Animal data (AD) were analysed through a mixed linear model and a logistic regression model was used to evaluate the relationship between VL and EVR. Analysis of MY and quality revealed that an incorrect setting of the milking was responsible for a higher LS and lower MY and LP, along with higher FP and PP compared to farms with adequate EVR. Except for PP, the height of the milking system significantly influenced all milk parameters. Conversely, VL affected all milking traits. A higher PR (70:30) was responsible for significantly lower LS and higher FP compared to a 60:40 PR. Similarly, the presence of AC showed a significant effect on FP and MY and a slight reduction in LS. Finally, the diameter and length of the pipeline (DL) ratio lower than 2.5 m was associated with a decrease in LS. These results suggest that buffaloes require specific milking parameters. Buffalo has a specific requirement for milking parameters.Incorrect milking setting increase somatic cells and reduce lactose content.Vacuum level (VL) affects milk yield (MY) and quality as well as somatic cells and lactose. Buffalo has a specific requirement for milking parameters. Incorrect milking setting increase somatic cells and reduce lactose content. Vacuum level (VL) affects milk yield (MY) and quality as well as somatic cells and lactose.
Mutual information based measures on complex interdependent networks of neuro data sets
Creators: name: Abdul Razak, Fatimah
Publisher: name: Imperial College London
Year: 2013

description: We assume that even the simplest model of the brain is nonlinear and ‘causal’. Proceeding with the first assumption, we need a measure that is able to capture nonlinearity and hence Mutual Information whose variants includes Transfer Entropy is chosen. The second assumption of ‘causality’ is defined in relation to prediction ala Granger causality. Both these assumptions led us to Transfer Entropy. We take the simplest case of Transfer Entropy, redefine it for our purposes of detecting causal lag and proceed with a systematic investigation of this value. We start off with the Ising model and then moved on to created an amended Ising model where we attempted to replicate ‘causality’. We do the same for a toy model that can be calculated analytically and thus simulations can be compared to its theoretical value. Lastly, we tackle a very interesting EEG data set where Transfer Entropy shall be used on different frequency bands to display possible emergent property of ‘causality’ and detect possible candidates for causal lag on the data sets.
Cells In Sillico – Parallel Tissue Development Simulation
Creators: name: Berghoff, Marco
Publisher: name: Karlsruher Institut für Technologie (KIT)
Year: 2021

description: Insights in cell dynamics and tissue development are constantly changing our understanding of fundamental biological processes including embryogenesis, wound healing, and tumorigenesis. The availability of high-quality microscopy data and an increasing understanding of single-cell effects are speeding up discoveries. However, many computational models still describe either a few cells in high detail or larger cell ensembles and tissues in rather coarse detail. We combine these two scales, therefore we developed a highly parallel version of the cellular Potts model and provides an agent-based model for controlling cellular events. The model can be modularly extended to a multimodel simulation at both scales. Based on the NAStJA framework, we implemented a scalable version that runs efficiently on high-performance computing systems. Our model scales beyond 10,000 cores in an approximately linear manner, enabling the simulation of large three-dimensional tissues. The strictly modular design allows flexible configuration of arbitrary models and enables applications in a wide range of research questions. Cells in Silico can be easily adapted to different modeling assumptions and helps computational scientists to extend their simulations to a new area of tissue simulations. As an example, we show a 1000^3 voxel cancer tissue simulation with sub-cellular resolution.
Potentiale für nachhaltige Mobilität in der Region Hannover
Creators: name: Levin-Keitel, Meike
name: Ruhrort, Lisa
name: Allert, Viktoria
name: Gödde, Jan
name: Krasilnikova, Nadezda
Publisher: name: TU Dortmund
Year: 2020
Subjects: subject: Nachhaltigkeit
subject: Hannover
subject: Homeoffice
subject: Umwelt
subject: Klima
subject: Verkehr
subject: Verkehrswende
subject: 710

description: Analyse der Ausgangssituation in Hinblick auf Verkehrsentwicklung, verkehrspolitische Diskurse sowie Veränderungen von Lebens- und Arbeitsformen in Großstadt und Umlandgemeinden.
description: Arbeitspapier der Nachwuchsforschungsgruppe MoveMe;1
Infrared singularities in the renormalization group flow of Yang-Mills theories in the axial gauge
Creators: name: Panza, Annamaria
name: Soldati, Roberto
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: It is shown, by explicit calculation in the axial gauge, that the renormalization group flow for the Wilson loop in perturbation theory does exhibit singularities and consequently it can not eventually reproduce the gauge invariant result, when the infrared cut off is removed
description: 12 pages, 3 figures, revised version to appear in Phys. Lett. B
MPEC 2024-E121 : 2021 LZ44
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
The phase 0.5 absorption in SW Sextantis-type cataclysmic variables
Creators: name: Hellier, Coel
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The SW Sextantis stars are a group of cataclysmic variables with distinctive observational characteristics, including absorption features in the emission line cores at phases 0.2-0.6. Hellier and Robinson have proposed that these features are caused by the accretion stream flowing over the accretion disk. However, in a simple model the absorption occurred at all orbital phases, which is contradicted by the data. I show that invoking a flared accretion disk resolves this problem.
description: 4 pages, 3 figures, LaTeX, To appear in PASP. Also at http://www.astro.keele.ac.uk/~ch/
Bottom-up approach to torus bifurcation in neuron models
Creators: name: Ju, Huiwen
name: Neiman, Alexander
name: Shilnikov, Andrey
Publisher: name: arXiv
Year: 2018
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: Dynamical Systems (math.DS)
subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We study the quasi-periodicity phenomena occurring at the transition between tonic spiking and bursting activities in exemplary biologically plausible Hodgkin-Huxley type models of individual cells and reduced phenomenological models with slow and fast dynamics. Using the geometric slow-fast dissection and the parameter continuation approach we show that the transition is due to either the torus bifurcation or the period-doubling bifurcation of a stable periodic orbit on the 2D slow-motion manifold near a characteristic fold. We examine various torus bifurcations including stable and saddle torus-canards, resonant tori, the co-existence of nested tori and the torus breakdown leading to the onset of complex and bistable dynamics in such systems.
description: 25 figures
Integrated machine learning and single-cell analysis reveal the prognostic and therapeutic potential of SUMOylation-related genes in ovarian cancer
Creators: name: Deng, zhenrong
Publisher: name: Zenodo
Year: 2024

description: Ovarian cancer (OC) has high mortality and chemoresistance rates, necessitating novel prognostic signatures and molecular biomarkers. SUMOylation, crucial in cellular stress responses, alters in various cancers. In this study, using multi-omics data, we characterized the unique features of SUMOylation in OC and revealed the close association between SUMOylation-related genes (SRGs) and OC malignancy. Integrated machine learning identified 22 prognostic SRGs based on the TCGA-OV cohort. Further single-cell analysis refined these findings, pinpointing five SRGs as novel biomarkers closely associated with OC function, metabolism and the tumor microenvironment. In cancer cells, SUMOylation levels regulate the expression of four SRGs (PI3, AUP1, CD200 and GNAS), which are closely associated with the activities of epigenetic regulation process and epithelial mesenchymal signaling. Notably, we discovered that AUP1 overexpression is a risk factor for chemoresistance of OC. In tumor microenvironment, CD8+ cytotoxic T cell with high CCDC80 (another SRG) expression exhibit inhibited cytotoxicity activities. Overall, five SRGs were identified and validated as novel prognostic and therapeutic targets, providing valuable insights for precision medicine of OC.
How to construct a coordinate representation of a Hamiltonian operator on a torus
Creators: name: Ishikawa, S.
name: Miyazaki, T.
name: Yamamoto, K.
name: Yamanobe, M.
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The dynamical system of a point particle constrained on a torus is quantized à la Dirac with two kinds of coordinate systems respectively; the Cartesian and toric coordinate systems. In the Cartesian coordinate system, it is difficult to express momentum operators in coordinate representation owing to the complication in structure of the commutation relations between canonical variables. In the toric coordinate system, the commutation relations have a simple form and their solutions in coordinate representation are easily obtained with, furthermore, two quantum Hamiltonians turning up. A problem comes out when the coordinate system is transformed, after quantization, from the Cartesian to the toric coordinate system.
description: 17 pages, LaTeX, 1 Figure included as a compressed uuencoded postscript file
Vector Supersymmetry of 2D Yang-Mills Theory
Creators: name: Boldo, J. L.
name: Sasaki, C. A. G.
name: Sorella, S. P.
name: Vilar, L. C. Q.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The vector supersymmetry of the 2D topological BF model is extended to 2D Yang-Mills. The consequences of the corresponding Ward identity on the ultraviolet behavior of the theory are analyzed.
description: Some references added
Histone Acetylation and Chemoresistance in Colorectal Cancer: an Opportunity for Effective Personalized Treatment
Creators: name: Alzoubi, Samer
Publisher: name: Imperial College London
Year: 2013

description: Colorectal cancer (CRC) is the most common cause of deaths in the West. Despite many therapeutic opportunities, drug resistance or recurrence has significant rates among patients. Nearly 50% of CRC patients develop metastases. Therefore, sensitive biomarker and effective treatments with minimal toxicity are needed. Genetic and epigenetic alterations play major roles in initiation, development, and chemoresistance of CRC. Histone deacetylase2 (HDAC2) over-expression is well-known in CRC. Many studies have associated HDAC2 over-expression and TP53 mutations with late stages of metastatic CRC (mCRC). However, the relationship between HDAC2 expression level and TP53 status and mCRC drug resistance is unclear. Here, I have investigated HDAC2 role in drug resistance and assessed the synergistic effects of DNA chemotherapeutics agents and HDAC inhibitors (HDACIs) on TP53 status in mCRC cell lines. I have shown for the first time that in mutated p53 mCRC cells (Sw480 and HT-29) the steady-state level of HDAC2 is low compared to wild-type p53 cells (HCT116 p53+/+). I have also found that increase in HDAC2 expression level in the highly resistant cell line HT-29 enhances drug resistance and its depletion by shRNA sensitises HT-29 to 5Fluorouracil (5FU) or Oxaliplatin (Oxa). The combined treatment of suberoylanilide hydroxamic acid (SAHA)/5FU and SAHA/Oxa was able to reduced HDAC2 expression level and induced mitotic cell death. However, SAHA/Doxorubicin combined treatment induced cell death in wild-type p53 (HCT116 p53+/+), null p53 (HCT116 p53-/-), and SW480 cell lines. This cell death associated with decrease in HDAC2 level. I have shown the association between sensitivity to treatment and reduction of HDAC2 level via bioluminescence imaging in combination with liposomal-encapsulated SAHA/Doxorubicin delivery to monitor tumour growth. I have observed a significant decrease in tumour growth and HADC2 level. Therefore, I suggest that unlike mutated p53, HDAC2 could be an epigenetic prognostic biomarker to predict therapeutic response in mCRC.
On the Nature of the X-ray Emission from M32
Creators: name: Loewenstein, M.
name: Hayashida, K.
name: Toneri, T.
name: Davis, D. S.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We have obtained the first broad-band X-ray spectra of the nearby compact elliptical galaxy M32 by using the ASCA satellite. The extracted spectra and X-ray luminosity are consistent with the properties of the hard spectral component measured in giant elliptical galaxies believed to originate from X-ray binaries. Two ASCA observations were performed two weeks apart; a 25% flux decrease and spectral softening occurred in the interval. We have also analyzed archival ROSAT HRI data, and discovered that the X-ray emission is dominated by a single unresolved source offset from the nucleus of M32. We argue that this offset, combined with the extremely rapid large magnitude variations, and hard X-ray spectrum combine to weakly favor a (single) X-ray binary over an AGN origin for the X-rays from M32. The nuclear black hole in M32 must be fuel-starved and/or accreting from a radiatively inefficient advection-dominated disk: the product of the accretion rate and the radiative efficiency must be less than 1e-10 solar masses per year if the X-ray source is indeed an X-ray binary.
description: 22 pages Latex plus 6 postscript figures, uses aasms4.sty, to appear in April 20 ApJ
MOESM1 of Administration of α-Galactosylceramide Improves Adenine-Induced Renal Injury
Creators: name: Cristhiane Aguiar
name: Cristiane Naffah-De-Souza
name: Castoldi, Angela
name: Matheus Corrêa-Costa
name: Tárcio Braga
name: Érika Naka
name: Amano, Mariane
name: Abate, Débora
name: Meire Hiyane
name: Cenedeze, Marcos
name: Filho, Alvaro E Silva
name: Câmara, Niels
Publisher: name: figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Marine Biology
subject: Science Policy

description: Supplementary material, approximately 3523 KB.
The Role of Caching in Future Communication Systems and Networks
Creators: name: Paschos, Georgios S.
name: Iosifidis, George
name: Tao, Meixia
name: Towsley, Don
name: Caire, Giuseppe
Publisher: name: arXiv
Year: 2018
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: This paper has the following ambitious goal: to convince the reader that content caching is an exciting research topic for the future communication systems and networks. Caching has been studied for more than 40 years, and has recently received increased attention from industry and academia. Novel caching techniques promise to push the network performance to unprecedented limits, but also pose significant technical challenges. This tutorial provides a brief overview of existing caching solutions, discusses seminal papers that open new directions in caching, and presents the contributions of this Special Issue. We analyze the challenges that caching needs to address today, considering also an industry perspective, and identify bottleneck issues that must be resolved to unleash the full potential of this promising technique.
description: to appear in IEEE JSAC
Automated Construction of Petri Net Performance Models from High-Precision Location Tracking Data
Creators: name: Anastasiou, Nikolas
Publisher: name: Imperial College London
Year: 2013

description: Stochastic performance models are widely used to analyse the performance and reliability of systems that involve the flow and processing of customers and resources. However, model formulation and parameterisation are traditionally manual and thus expensive, intrusive and error-prone. This thesis illustrates the feasibility of automated performance model construction from high-precision location tracking data. In particular, we present a methodology based on a four-stage data processing pipeline which automatically constructs Coloured Generalised Stochastic Petri Net (CGSPN) performance models from an input dataset consisting of raw location tracking traces. The output performance model can be visualised using PIPE2, the platform independent Petri Net editor. The developed methodology can be applied to customer-processing systems which support multiple customers classes and can capture the initial and inter-routing probability of the customer flow of the underlying system. Furthermore, it detects any presence-based synchronisation conditions that may be inherent in the underlying system and the presence of service cycles. Service time distributions, one for each customer class, of each service area in the system and travelling time distributions between pairs of service areas are also characterised. PEPERCORN, the tool that implements the developed methodology, is also presented. In addition to the latter, this thesis presents LocTrackJINQS, the extensible, location-aware Queueing Network simulator. LocTrackJINQS was developed to support location-based research. It has the ability to simulate a user-specified Queueing Network and while simulation progresses, it generates and outputs location tracking data – associated with the movement of the customers in the network – in a trace file. Our methodology is evaluated through six case studies. These case studies use synthetic location tracking data generated by LocTrackJINQS. The obtained results suggest that the methodology can infer the abstract structure of the system – specified in terms of the locations and service radii of the system’s service areas (max error 0.320 m and 0.277 m respectively) and customer flow – and approximate its service time delays well. In fact, the maximum relative entropy value that was obtained between the simulated and inferred service time distributions is 0.324 nats. Furthermore, whenever synchronisation between service areas takes place, the simulated synchronisation conditions are successfully inferred.
Oral history interview with Marc Connelly, 1959
Publisher: name: Columbia University
Year: 2020
Subjects: Screenwriters
Dramatists
Theater--Production and direction
Motion picture authorship

description: Career in New York theater including "Wisdom Tooth," "Beggar on Horseback," "Green Pastures"; screen writing in Hollywood from 1927: "Cradle Song" and "Captains Courageous"; Motion Picture Production Code: Butterworth Athletic Club; reflections on theater, acting, the 1920s and Prohibition. Audio is comprised of narrator's excerpts from the Westinghouse Broadcasting Company's radio program series "Memoirs of the Movies"
Investigation of Corticosteroid Responsiveness in Airway Smooth Muscle Cells of Severe Asthma
Creators: name: Chang, Po-Jui
Publisher: name: Imperial College London
Year: 2012

description: Asthma is characterised by airway inflammation, hyper-responsiveness and airway remodelling. Features of airway remodelling include hypertrophy/hyperplasia of airway smooth muscle cells (ASMC), which possess an important synthetic capacity in addition to their contractile function. Patients with severe asthma respond poor to even high-dose corticosteroids and consume enormous healthcare resources. Corticosteroid insensitivity in peripheral blood mononuclear cells and alveolar macrophages of severe asthma has been reported. It is still unclear whether ASMC display a similar phenotype. I hypothesised that corticosteroid insensitivity exists in ASMC of severe asthma, and the underlying mechanisms were investigated. ASMC were obtained from endobronchial biopsy and were experimented with at passage 4-5. TNF-α induced CCL11, CXCL8 and CXCL10 expression in ASMC. IFN-γ suppressed TNFα-induced CCL11 and CXCL8, through attenuation of NF-κB (p65) recruitment to the gene promoters, but potentiated induced CXCL10. CX3CL1 was induced synergistically only by combined both cytokines. Baseline and TNFα-induced CCL11 expression in non-severe asthma were greater than the healthy and severe asthma, while IFNγ-induced CXCL10 was increased in severe asthma. Whereas TNFα-induced p65 expression was increased in severe asthma, there was no difference in nuclear translocation or recruitment to the gene promoters between groups. The effect of dexamethasone was reduced in terms of suppressing induced CCL11 and CXCL8 expression in severe asthma, while the potentiating effect on CX3CL1 was not different between groups. Of the mitogen-activated protein kinases (MAPK), p38 activation was heightened in severe asthma, and p38 inhibition restored the corticosteroid sensitivity. Expression of glucocorticoid receptor (GR) was decreased in asthma, while nuclear translocation of GR was impaired only in severe asthma. In conclusion, there is differential expression of inflammatory chemokines in ASMC of asthma. Corticosteroid insensitivity exists in ASMC of severe asthma in terms of suppressing induced chemokines, partially attributed to heightened p38 MAPK activity and impaired nuclear translocation of GR.
U-duality and Intersecting D-branes
Creators: name: Sen, Ashoke
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Spectrum of elementary string states in type II string theory compactified on a torus contains short multiplets which are invariant under only one quarter of the space-time supersymmetry generators. $U$-duality transformation converts these states into bound states of Dirichlet branes which wrap around intersecting cycles of the internal torus. We study a class of these bound states that are dual to the elementary string states at the first excited level, and argue that the degeneracy of these bound states is in agreement with the $U$-duality prediction.
description: LaTeX file, 7 pages
Imagining Humans in the Age of DNA: Genetics and Contemporary British Fiction
Creators: name: Azevedo Soares, Andreia
Publisher: name: Imperial College London
Year: 2012

description: This thesis examines to what extent modern genetics has influenced novelists to adopt a more deterministic view of human beings. It has been claimed that molecular biology, behavioural genetics and evolutionary psychology have challenged traditional ideas about humankind. My hypothesis is that if gene-centred disciplines changed the way we see ourselves, then this would have implications for the literary novel, a genre that depends greatly on representations of humans. In analysing how genetics was incorporated in contemporary British fiction, I try to uncover the ways in which the human characters deal with – or are constrained or empowered by – scientific products or concepts. In addition, I seek to understand what novelists know and think about human genetics, and whether they believe it influenced their stories. Attention is also paid to novelists’ relationship with scientists’ cognitive authority. Specifically, I am interested in whether experts and scientific knowledge were positioned hierarchically above lay audiences and other forms of knowledge. To answer those questions, extended semi-structured interviews and textual analysis were chosen as main research methods. Six literary novels were selected for analysis. This corpus consists of: A.S. Byatt’s A Whistling Woman, Carole Cadwalladr’s The Family Tree, Margaret Drabble’s The Peppered Moth, Maggie Gee’s The Ice People, Simon Mawer’s Mendel’s Dwarf and David Mitchell’s Cloud Atlas. The main conclusion of this project is that novelists are able to incorporate ideas about genetics in their texts without simply perpetuating reductionist discourses. Literary novels offer several advantages compared to the expository writing: they are a flexible literary form; deal imaginatively with the human experience; and effortlessly accommodate multiple perspectives, open-ended questions and complex ideas such as doubt and ambiguity. As such, this genre affords the opportunity to explore contemporary science as a provisional, contingent and socially-embedded endeavour.