cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Modeling the Black hole Merger of QSO 3C 186
Creators: name: Lousto, Carlos O.
name: Zlochower, Yosef
name: Campanelli, Manuela
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Recent detailed observations of the radio-loud quasar 3C 186 indicate the possibility that a supermassive recoiling black hole is moving away from the host galaxy at a speed of nearly 2100km/s. If this is the case, we can model the mass ratio and spins of the progenitor binary black hole using the results of numerical relativity simulations. We find that the black holes in the progenitor must have comparable masses with a mass ratio $q=m_1/m_2>1/4$ and the spin of the primary black hole must be $α_2=S_2/m_2^2>0.4$. The final remnant of the merger is bounded by $α_f>0.45$ and at least $4\%$ of the total mass of the binary system is radiated into gravitational waves. We consider four different pre-merger scenarios that further narrow those values. Assuming, for instance, a cold accretion driven merger model, we find that the binary had comparable masses with $q=0.70^{+0.29}_{-0.21}$ and the normalized spins of the larger and smaller black holes were $α_2=0.94^{+0.06}_{-0.22}$ and $α_1=0.95^{+0.05}_{-0.09}$. We can also estimate the final recoiling black hole spin $α_f=0.93^{+0.02}_{-0.03}$ and that the system radiated $9.6^{+0.8}_{-1.4}\%$ of its total mass, making the merger of those black holes the most energetic event ever observed.
description: 4 pages, 2 figures
Additional file 8 of CoSTA: unsupervised convolutional neural network learning for spatial transcriptomics analysis
Creators: name: Xu, Yang
name: McCord, Rachel Patton
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 8. Supplementary Fig. 8: Comparison of SPARK, SpatialDE, CoSTA, and pixel overlap results. (A) Overlap of gene lists correlated with Vim, Ctsd, and Gfap at 2 weeks after injury identified by CoSTA, SPARK, SpatialDE, and overlap analysis (“Slide-seq”). (B) Examples of gene expression images for genes detected as similar to Vim, Gfap, and Ctsd by SPARK and also by CoSTA (left) or SPARK and not CoSTA (right). Numbers below images indicate the rank of the given gene in the list of correlated genes. See Figure S7 for expression patterns of the query genes. All images are scaled between 0 and 1 for visualization purposes. Key visible regions of high expression in Vim, Gfap, and Ctsd are circled in red for cross comparison of all images. (C) Gene Ontology term enrichment evaluated by Gorilla using the ranked correlated gene list produced by CoSTA (see Table S4). (D) Examples of gene expression images for genes highly ranked by CoSTA only (left), pixel only (middle), and both (right) as similar to Vim, Gfap, and Ctsd. Annotations next to gene names indicate rankings in CoSTA “C” and Pixel “P”.
Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities
Creators: name: Chrienova, Zofia
name: Nepovimova, Eugenie
name: Andrys, Rudolf
name: Dolezal, Rafael
name: Janockova, Jana
name: Muckova, Lubica
name: Fabova, Lenka
name: Soukup, Ondrej
name: Oleksak, Patrik
name: Valis, Martin
name: Korabecny, Jan
name: Marco-Contelles, José
name: Kuca, Kamil
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biochemistry
Medicine
Molecular Biology
Neuroscience
Pharmacology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Cancer
Mental Health
Hematology

description: Twenty-four novel compounds bearing tetrahydroacridine and N-propargyl moieties have been designed, synthesised, and evaluated in vitro for their anti-cholinesterase and anti-monoamine oxidase activities. Propargyltacrine 23 (IC50 = 21 nM) was the most potent acetylcholinesterase (AChE) inhibitor, compound 20 (IC50 = 78 nM) showed the best inhibitory human butyrylcholinesterase (hBChE) profile, and ligand 21 afforded equipotent and significant values on both ChEs (human AChE [hAChE]: IC50 = 0.095 ± 0.001 µM; hBChE: IC50 = 0.093 ± 0.003 µM). Regarding MAO inhibition, compounds 7, 15, and 25 demonstrated the highest inhibitory potential towards hMAO-B (IC50 = 163, 40, and 170 nM, respectively). In all, compounds 7, 15, 20, 21, 23, and 25 exhibiting the most balanced pharmacological profile, were submitted to permeability and cell viability tests. As a result, 7-phenoxy-N-(prop-2-yn-1-yl)-1,2,3,4-tetrahydroacridin-9-amine hydrochloride (15) has been identified as a permeable agent that shows a balanced pharmacological profile [IC50 (hAChE) = 1.472 ± 0.024 µM; IC50 (hBChE) = 0.659 ± 0.077 µM; IC50 (hMAO-B) = 40.39 ± 5.98 nM], and consequently, as a new hit-ligand that deserves further investigation, in particular in vivo analyses, as the preliminary cell viability test results reported here suggest that this is a relatively safe therapeutic agent.
title: Zur Nordprovinz der El Argar-Kultur
title: Zur Nordprovinz der El Argar-Kultur
titleType: Subtitle
Creators: name: Brandherm, Dirk
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Huerta de Murcia
subject: Huerta de Murcia

description: Madrider Mitteilungen, Vol. 37 (1996)
description: Deutsche Zusammenfassung folgt.
Additional file 1: of Coping with dry eyes: a qualitative approach
Creators: name: Yeo, Sharon
name: Tong, Louis
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Supplementary materials. Script for Dry Eye Focus Group. Table S1. Examples of strategies used in the themes uncovered in the focus groups. Table S2. The number of times focus group themes were mentioned by participants. (DOCX 21Â kb)
Close-up images of the final Philae landing site on comet 67P/Churyumov-Gerasimenko acquired by the ROLIS camera
Creators: name: Schröder, S. E.
name: Mottola, S.
name: Arnold, G.
name: Grothues, H. -G.
name: Jaumann, R.
name: Keller, H. U.
name: Michaelis, H.
name: Bibring, J. -P.
name: Pelivan, I.
name: Koncz, A.
name: Otto, K.
name: Remetean, E.
name: Souvannavong, F.
name: Dolives, B.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: After coming to rest on the night side of comet 67P/Churyumov-Gerasimenko, the ROLIS camera on-board Rosetta's Philae lander acquired five images of the surface below the lander, four of which were with the aid of LED illumination of different colors. The images confirm that Philae was perched on a sloped surface. A local horizon is visible in one corner of the image, beyond which we can see the coma. Having spent a full day on the surface Philae was commanded to lift and rotate, after which a final, sixth, LED image was acquired. The change in perspective allowed us to construct a shape model of the surface. The distance to the foreground was about 80 cm, much larger than the nominal 30 cm. This caused stray light, rather than directly reflected LED light, to dominate the image signal, complicating the analysis. The images show a lumpy surface with a roughness of apparently fractal nature. Its appearance is completely different from that of the first landing site, which was characterized by centimeter to meter-sized debris (Mottola et al., 2015). We recognize neither particles nor pores at the image resolution of 0.8 mm per pixel and large color variations are absent. The surface has a bi-modal brightness distribution that can be interpreted in terms of the degree of consolidation, a hypothesis that we support with experimental evidence. We propose the surface below the lander to consist of smooth, cracked plates with unconsolidated edges, similar to terrain seen in CIVA images.
title: Zambujal (Portugal): Vorbericht über die Grabungen 1994
title: Zambujal (Portugal): Vorbericht über die Grabungen 1994
titleType: Subtitle
Creators: name: Kunst, Michael
name: Uerpmann, Hans-Peter
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Zambujal (Torres Vedras, Lisboa, Port.)
subject: Zambujal (Torres Vedras, Lisboa, Port.)

description: Madrider Mitteilungen, Vol. 37 (1996)
description: Deutsche Zusammenfassung folgt.
Additional file 9 of CoSTA: unsupervised convolutional neural network learning for spatial transcriptomics analysis
Creators: name: Xu, Yang
name: McCord, Rachel Patton
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 9. Supplementary Fig. 9: Expression patterns of SE genes identified by CoSTA 2 weeks after brain injury. SE genes were clustered into 6 groups by SpatialDE and CoSTA. CoSTA cluster numbers correspond to Figure 4d and the most similar SpatialDE cluster is placed below the most closely corresponding CoSTA cluster when possible. The SpatialDE cluster containing Vim, Gfap, and Ctsd is cluster 2. Average expression pattern in 3rd row shows the overall pattern of all genes combined in the 2-week dataset.
Survey of cold water lines in protoplanetary disks: indications of systematic volatile depletion
Creators: name: Du, Fujun
name: Bergin, Edwin Anthony
name: Hogerheijde, Michiel
name: van Dishoeck, Ewine F.
name: Blake, Geoff
name: Bruderer, Simon
name: Cleeves, Ilse
name: Dominik, Carsten
name: Fedele, Davide
name: Lis, Dariusz C.
name: Melnick, Gary
name: Neufeld, David
name: Pearson, John
name: Yildiz, Umut
Publisher: name: arXiv
Year: 2017
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We performed very deep searches for 2 ground-state water transitions in 13 protoplanetary disks with the HIFI instrument on-board the Herschel Space Observatory, with integration times up to 12 hours per line. Two other water transitions that sample warmer gas were also searched for with shallower integrations. The detection rate is low, and the upper limits provided by the observations are generally much lower than predictions of thermo-chemical models with canonical inputs. One ground-state transition is newly detected in the stacked spectrum of AA Tau, DM Tau, LkCa 15, and MWC 480. We run a grid of models to show that the abundance of gas-phase oxygen needs to be reduced by a factor of at least ~100 to be consistent with the observational upper limits (and positive detections) if a dust-to-gas mass ratio of 0.01 were to be assumed. As a continuation of previous ideas, we propose that the underlying reason for the depletion of oxygen (hence the low detection rate) is the freeze-out of volatiles such as water and CO onto dust grains followed by grain growth and settling/migration, which permanently removes these gas-phase molecules from the emissive upper layers of the outer disk. Such depletion of volatiles is likely ubiquitous among different disks, though not necessarily to the same degree. The volatiles might be returned back to the gas phase in the inner disk (within about 15 AU), which is consistent with current constraints. Comparison with studies on disk dispersal due to photoevaporation indicates that the timescale for volatile depletion is shorter than that of photoevaporation.
description: Accepted for publication in ApJ
1,3,4-Oxadiazole-naphthalene hybrids as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative activity, apoptotic effect, and in silico studies
Creators: name: Hagras, Mohamed
name: Saleh, Marwa A.
name: Eldin, Rogy R. Ezz
name: Abuelkhir, Abdelrahman A.
name: Khidr, Emad Gamil
name: El-Husseiny, Ahmed A.
name: El-Mahdy, Hesham A.
name: Elkaeed, Eslam B.
name: Eissa, Ibrahim H.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: In the current work, some 1,3,4-oxadiazole-naphthalene hybrids were designed and synthesised as VEGFR-2 inhibitors. The synthesised compounds were evaluated in vitro for their antiproliferative activity against two human cancer cell lines namely, HepG-2 and MCF-7. Compounds that exhibited promising cytotoxicity (5, 8, 15, 16, 17, and 18) were further evaluated for their VEGFR-2 inhibitory activities. Compound 5 showed good antiproliferative activity against both cell lines and inhibitory effect on VEGFR-2. Besides, it induced apoptosis by 22.86% compared to 0.51% in the control (HepG2) cells. This apoptotic effect was supported by a 5.61-fold increase in the level of caspase-3 compared to the control cells. Moreover, it arrested the HepG2 cell growth mostly at the Pre-G1 phase. Several in silico studies were performed including docking, ADMET, and toxicity studies to predict binding mode against VEGFR-2 and to anticipate pharmacokinetic, drug-likeness, and toxicity of the synthesised compounds.
title: Dos ídolos calcolíticos en "La Gallega", Valencina de la Concepción, Sevilla
title: Dos ídolos calcolíticos en "La Gallega", Valencina de la Concepción, Sevilla
titleType: Subtitle
Creators: name: Martín Espinosa, Amparo
name: Ruiz Moreno, María Teresa
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: La Gallega (Valencina de la Concepción, Sevilla)
subject: La Gallega (Valencina de la Concepción, Sevilla)

description: Madrider Mitteilungen, Vol. 37 (1996)
description: Folgt.
Criterion for Stability of a Special Relativistically Covariant Dynamical System
Creators: name: Horwitz, L. P
name: Zucker, D.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Classical Physics (physics.class-ph)
subject: Mathematical Physics (math-ph)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: We study classically the problem of two relativistic particles with an invariant Duffing-like potential which reduces to the usual Duffing form in the nonrelativistic limit. We use a special relativistic generalization (RGEM) of the geometric method (GEM) developed for the analysis of nonrelativistic Hamiltonian systems to study the local stability of a relativistic Duffing oscillator. Poincar'e plots of the simulated motion are consistent with the RGEM. We found a threshold for the external driving force required for chaotic behavior in the Minkowski spacetime.
description: 11 pages. 18 figures
Additional file 1: of mORCA: ubiquitous access to life science web services
Creators: name: Diaz-Del-Pino, Sergio
name: Trelles, Oswaldo
name: Falgueras, Juan
Publisher: name: figshare
Year: 2018
Subjects: subject: Cell Biology
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Marine Biology
subject: Science Policy
subject: Plant Biology

description: State-of-the-art Apps. A PDF file with a full list of apps belonging to the stores of the main mobile platforms, its descriptions, links, and icons. (PDF 1546Â kb)
title: Der geometrische Dekor des Reichen Saales von Madinat az-Zahra : eine Untersuchung zur spanisch-islamischen Ornamentik
title: Der geometrische Dekor des Reichen Saales von Madinat az-Zahra : eine Untersuchung zur spanisch-islamischen Ornamentik
titleType: Subtitle
Creators: name: Kubisch, Natascha
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Madinat al-Zahra' (Córdoba)
subject: Madinat al-Zahra' (Córdoba)

description: Madrider Mitteilungen, Vol. 38 (1997)
description: Deutsche Zusammenfassung folgt.
The Hubble Space Telescope UV Legacy Survey of Galactic Globular Clusters. VIII. Preliminary Public Catalog Release
Creators: name: Soto, M.
name: Bellini, A.
name: Anderson, J.
name: Piotto, G.
name: Bedin, L. R.
name: van der Marel, R. P.
name: Milone, A. P.
name: Brown, T. M.
name: Cool, A. M.
name: King, I. R.
name: Sarajedini, A.
name: Granata, V.
name: Cassisi, S.
name: Aparicio, A.
name: Hidalgo, S.
name: Ortolani, S.
name: Nardiello, D.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The Hubble Space Telescope (HST) UV Legacy Survey of Galactic Globular Clusters (GO-13297) has been specifically designed to complement the existing F606W and F814W observations of the Advanced Camera for Surveys (ACS) Globular Cluster Survey (GO-10775) by observing the most accessible 47 of the previous survey's 65 clusters in three WFC3/UVIS filters F275W, F336W, and F438W. The new survey also adds super-solar metallicity open cluster NGC 6791 to increase the metallicity diversity. The combined survey provides a homogeneous 5-band data set that can be used to pursue a broad range of scientific investigations. In particular, the chosen UV filters allow the identification of multiple stellar populations by targeting the regions of the spectrum that are sensitive to abundance variations in C, N, and O. In order to provide the community with uniform preliminary catalogs, we have devised an automated procedure that performs high-quality photometry on the new UV observations (along with similar observations of seven other programs in the archive). This procedure finds and measures the potential sources on each individual exposure using library point-spread functions and cross-correlates these observations with the original ACS-Survey catalog. The catalog of 57 clusters we publish here will be useful to identify stars in the different stellar populations, in particular for spectroscopic follow-up. Eventually, we will construct a more sophisticated catalog and artificial-star tests based on an optimal reduction of the UV survey data, but the catalogs presented here give the community the chance to make early use of this HST Treasury survey.
description: 10 pages, 4 figures. Accepted for publication in AJ. The catalogs from this program can be accessed at http://www.astro.uda.cl/public_release/globularclusters41.html and http://groups.dfa.unipd.it/ESPG/treasury.php
Additional file 1: of Molecular and functional signatures in a novel Alzheimer’s disease mouse model assessed by quantitative proteomics
Creators: name: Kim, Dong
name: Joonho Park
name: Dohyun Han
name: Jinhee Yang
name: Ahbin Kim
name: Jongmin Woo
name: Youngsoo Kim
name: Inhee Mook-Jung
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology

description: Supplementary Methods. (DOCX 31 kb)
title: El mausoleo del Dintel de los Ríos de Mérida, Revue Anabaraecus y el culto de la confluencia
title: El mausoleo del Dintel de los Ríos de Mérida, Revue Anabaraecus y el culto de la confluencia
titleType: Subtitle
Creators: name: Canto, Alicia
name: Bejarano, Ana
name: Palma, Félix
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Mérida (Badajoz)
subject: Mérida (Badajoz)

description: Madrider Mitteilungen, Vol. 38 (1997)
description: Folgt.
Models for classifying spaces for $\mathbb{Z}\rtimes \mathbb{Z}$
Creators: name: Juan-Pineda, Daniel
name: Trujillo-Negrete, Alejandra
Publisher: name: arXiv
Year: 2017
Subjects: subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics
subject: 20F65, 55R35

description: We construct two models for the classifying space for the family of infinite cyclic subgroups of the fundamental group of the Klein bottle. These examples do not fit in general constructions previously done, for example, for hyperbolic groups.
description: 14 pages
The scale effects of the spatial autocorrelation measurement: aggregation level and spatial resolution
Creators: name: Zhang, Boen
name: Xu, Gang
name: Jiao, Limin
name: Liu, Jiafeng
name: Dong, Ting
name: Li, Zehui
name: Liu, Xiaoping
name: Liu, Yaolin
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Information Systems not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: The scale effects of the spatial autocorrelation (SA) measurement has been explored for decades. However, the effects of the data aggregation levels and spatial resolution on the SA measurement are often confused. Whether the two types of scale effects are the same is still unclear and requires further investigation. We retrieved the land surface temperature (LST) from Landsat 8 images in 30 capital cities of China. By aggregating the LST images, we observed a decrease in the SA of the LST as the data aggregation level increased; this relationship can be fitted well with a negative logarithmic function. We derived an indicator to measure the scale effects intensity of SA, which was negatively correlated with the spatial complexity of LST. Both aggregating images and the increasing spatial resolution induce weaker SA, but the effect of the former was stronger. The aggregating images negatively affected the SA degree regardless of the spatial resolutions of the original images. The SA degrees of the aggregated images were far below those of the real-life images. This study suggests that the scale effects caused by aggregation levels and spatial resolutions are different, and cautions should be taken when applying relevant conclusions derived from aggregating images.
Additional file 3: of Benefits of VCE-003.2, a cannabigerol quinone derivative, against inflammation-driven neuronal deterioration in experimental Parkinson’s disease: possible involvement of different binding sites at the PPARγ receptor
Creators: name: García, Concepción
name: Gómez-Cañas, María
name: Burgaz, Sonia
name: Palomares, Belén
name: Gómez-Gálvez, Yolanda
name: Palomo-Garo, Cristina
name: Campo, Sara
name: Ferrer-Hernández, Joel
name: Pavicic, Carolina
name: Navarrete, Carmen
name: M. Luz Bellido
name: García-Arencibia, Moisés
name: M. Ruth Pazos
name: Muñoz, Eduardo
name: Fernández-Ruiz, Javier
Publisher: name: figshare
Year: 2018
Subjects: subject: Molecular Biology
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Supplementary information and Supplementary Figures S3–S5. Effects of VCE-003.2 in 6-hydroxydopamine-lesioned mice (PDF 564 kb)
title: Die Mysterien von Panóias (Vila Real, Portugal)
title: Die Mysterien von Panóias (Vila Real, Portugal)
titleType: Subtitle
Creators: name: Alföldy, Géza
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 38 (1997)
description: Deutsche Zusammenfassung folgt.
Positional scanning of natural product hispidol’s ring-B: discovery of highly selective human monoamine oxidase-B inhibitor analogues downregulating neuroinflammation for management of neurodegenerative diseases
Creators: name: Hassan, Ahmed H. E.
name: Kim, Hyeon Jeong
name: Gee, Min Sung
name: Park, Jong-Hyun
name: Jeon, Hye Rim
name: Lee, Cheol Jung
name: Choi, Yeonwoo
name: Moon, Suyeon
name: Lee, Danbi
name: Lee, Jong Kil
name: Park, Ki Duk
name: Lee, Yong Sup
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Neuroscience
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Multifunctional molecules might offer better treatment of complex multifactorial neurological diseases. Monoaminergic pathways dysregulation and neuroinflammation are common convergence points in diverse neurodegenerative and neuropsychiatric disorders. Aiming to target these diseases, polypharmacological agents modulating both monoaminergic pathways and neuroinflammatory were addressed. A library of analogues of the natural product hispidol was prepared and evaluated for inhibition of monoamine oxidases (MAOs) isoforms. Several molecules emerged as selective potential MAO B inhibitors. The most promising compounds were further evaluated in vitro for their impact on microglia viability, induced production of proinflammatory mediators and MAO-B inhibition mechanism. Amongst tested compounds, 1p was a safe potent competitive reversible MAO-B inhibitor and inhibitor of microglial production of neuroinflammatory mediators; NO and PGE2. In-silico study provided insights into molecular basis of the observed selective MAO B inhibition. This study presents compound 1p as a promising lead compound for management of neurodegenerative disease.
title: La villa romana de Vilauba, Banyoles (provincia de Girona) : excavación de un ámbito de culto doméstico
title: La villa romana de Vilauba, Banyoles (provincia de Girona) : excavación de un ámbito de culto doméstico
titleType: Subtitle
Creators: name: Castanyer i Masoliver, Pere
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Vilauba (Banyoles, Gerona)
subject: Vilauba (Banyoles, Gerona)

description: Madrider Mitteilungen, Vol. 38 (1997)
description: Folgt.
Room-temperature high detectivity mid-infrared photodetectors based on black arsenic phosphorus
Creators: name: Long, Mingsheng
name: Gao, Anyuan
name: Wang, Peng
name: Xia, Hui
name: Ott, Claudia
name: Pan, Chen
name: Fu, Yajun
name: Liu, Erfu
name: Chen, Xiaoshuang
name: Lu, Wei
name: Nilges, Tom
name: Xu, Jianbin
name: Wang, Xiaomu
name: Hu, Weida
name: Miao, Feng
Publisher: name: arXiv
Year: 2017
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The mid-infrared (MIR) spectral range, pertaining to important applications such as molecular 'fingerprint' imaging, remote sensing, free space telecommunication and optical radar, is of particular scientific interest and technological importance. However, state-of-the-art materials for MIR detection are limited by intrinsic noise and inconvenient fabrication processes, resulting in high cost photodetectors requiring cryogenic operation. We report black arsenic-phosphorus-based long wavelength infrared photodetectors with room temperature operation up to 8.2 um, entering the second MIR atmospheric transmission window. Combined with a van der Waals heterojunction, room temperature specific detectivity higher than 4.9*10^9 Jones was obtained in the 3-5 um range. The photodetector works in a zero-bias photovoltaic mode, enabling fast photoresponse and low dark noise. Our van der Waals heterojunction photodector not only exemplify black arsenic-phosphorus as a promising candidate for MIR opto-electronic applications, but also pave the way for a general strategy to suppress 1/f noise in photonic devices.
description: To appear in Science Advances; 27 pages, 3 figures, 9 supplementary figures; submitted on Feb. 24th, 2017
title: Die römischen Villen von Milreu (Algarve, Portugal) : ein Beitrag zur Romanisierung der südlichen Provinz Lusitania
title: Die römischen Villen von Milreu (Algarve, Portugal) : ein Beitrag zur Romanisierung der südlichen Provinz Lusitania
titleType: Subtitle
Creators: name: Teichner, Felix
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Milreu, villa (Faro, Port.)
subject: Milreu, villa (Faro, Port.)

description: Madrider Mitteilungen, Vol. 38 (1997)
description: Folgt.
Identification of key genes and their association with immune infiltration in adipose tissue of obese patients: a bioinformatic analysis
Creators: name: Wen, Jie
name: Wang, Liwen
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Mental Health
subject: Hematology
subject: Computational Biology

description: Immune cell-mediated adipose tissue (AT) inflammation contributes to obesity-related metabolic disorders, but the precise underlying mechanisms remain largely elusive. In this study, we used the R software to screen key differentially expressed genes (DEGs) in AT from lean and obese individuals and conducted function enrichment analysis. We then analysed their PPI network by using the STRING database. Hub genes were screened by cytohubba plugin. Subsequently, CIBERSORTx was used to predict the proportion of immune cells in AT from lean and obese subjects. Finally, the correlation between hub genes and immune cell proportions was analysed. These studies identified 290 DEGs in the AT between lean and obese subjects. Among them, IL6, CCL19, CXCL8, CXCL12, CCL2, CCL3, CCL4, CXCL2, IL1B, and CXCL1 were proved to be hub genes in regulating the protein-protein interaction (PPI) network. We also found that CXCL8 is positively correlated with resting NK cells, monocytes, activated mast cells, and eosinophils, but negatively correlated with CD8+ T cells and activated NK cells in obese individuals. Taken together, our study identified key genes in AT that are correlated with immune cell infiltration, uncovering potential new targets for the prevention and treatment of obesity and its related complications via regulating the immune microenvironment.
Two special subgroups of the universal sofic group
Creators: name: Cavaleri, Matteo
name: Munteanu, Radu B.
name: Paunescu, Liviu
Publisher: name: arXiv
Year: 2017
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 46M07, 28Dxx, 05A05

description: We define a subgroup of the universal sofic group, obtained as the normaliser of a separable abelian subalgebra. This subgroup can be obtained as an extension by the group of automorphisms on a standard probability space. We show that each sofic representation can be conjugated inside this subgroup.
description: 11 pages
title: Two dedications to Divus Augustus and Diva Augusta from Augusta Emerita and the early development of the imperial cult in Lusitania re-examined
title: Two dedications to Divus Augustus and Diva Augusta from Augusta Emerita and the early development of the imperial cult in Lusitania re-examined
titleType: Subtitle
Creators: name: Edmondson, Jonathan
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 38 (1997)
description: Follows.
Dataset Distillation with Neural Characteristic Function: A Minmax Perspective
Creators: name: Wang, Shaobo
name: Yang, Yicun
name: Liu, Zhiyuan
name: Sun, Chenghao
name: Hu, Xuming
name: He, Conghui
name: Zhang, Linfeng
Publisher: name: arXiv
Year: 2025
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Artificial Intelligence (cs.AI)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Dataset distillation has emerged as a powerful approach for reducing data requirements in deep learning. Among various methods, distribution matching-based approaches stand out for their balance of computational efficiency and strong performance. However, existing distance metrics used in distribution matching often fail to accurately capture distributional differences, leading to unreliable measures of discrepancy. In this paper, we reformulate dataset distillation as a minmax optimization problem and introduce Neural Characteristic Function Discrepancy (NCFD), a comprehensive and theoretically grounded metric for measuring distributional differences. NCFD leverages the Characteristic Function (CF) to encapsulate full distributional information, employing a neural network to optimize the sampling strategy for the CF's frequency arguments, thereby maximizing the discrepancy to enhance distance estimation. Simultaneously, we minimize the difference between real and synthetic data under this optimized NCFD measure. Our approach, termed Neural Characteristic Function Matching (\mymethod{}), inherently aligns the phase and amplitude of neural features in the complex plane for both real and synthetic data, achieving a balance between realism and diversity in synthetic samples. Experiments demonstrate that our method achieves significant performance gains over state-of-the-art methods on both low- and high-resolution datasets. Notably, we achieve a 20.5\% accuracy boost on ImageSquawk. Our method also reduces GPU memory usage by over 300$\times$ and achieves 20$\times$ faster processing speeds compared to state-of-the-art methods. To the best of our knowledge, this is the first work to achieve lossless compression of CIFAR-100 on a single NVIDIA 2080 Ti GPU using only 2.3 GB of memory.
description: Accepted by CVPR 2025, 11 pages, 7 figures
MOESM1 of Production of Aspergillus niger biomass on sugarcane distillery wastewater: physiological aspects and potential for biodiesel production
Creators: name: Chuppa-Tostain, Graziella
name: Hoarau, Julien
name: Watson, Marie
name: Adelard, Laetitia
name: Sing, Alain Shum Cheong
name: Yanis Caro
name: Grondin, Isabelle
name: Bourven, Isabelle
name: Francois, Jean-Marie
name: Girbal-Neuhauser, Elisabeth
name: Petit, Thomas
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Additional file 1. Data from Fig. 2 including standard deviations.
Anisotropic magnetoresistance and piezoelectric effect in GaAs Hall samples
Creators: name: Ciftja, Orion
Publisher: name: arXiv
Year: 2017
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: In this work, we argue that an anisotropic interaction potential may stabilize anisotropic liquid phases of electrons even in a strong magnetic field regime where normally one expects to see only isotropic quantum Hall or isotropic Fermi liquid states. We use this approach to support a theoretical framework that envisions the possibility of an anisotropic liquid crystalline state of electrons in the lowest Landau level. In particular, we argue that an anisotropic liquid state of electrons may stabilize in the lowest Landau level close to the liquid-solid transition region at filling factor $ν=1/6$ for a given anisotropic Coulomb interaction potential. Quantum Monte Carlo simulations for a liquid crystalline state with broken rotational symmetry indicate stability of liquid crystalline order consistent with the existence of an anisotropic liquid state of electrons stabilized by anisotropy at filling factor $ν=1/6$ of the lowest Landau level.
description: 10 pages, 7 figures
Additional file 2: Figure S2. of Benefits of VCE-003.2, a cannabigerol quinone derivative, against inflammation-driven neuronal deterioration in experimental Parkinson’s disease: possible involvement of different binding sites at the PPARγ receptor
Creators: name: García, Concepción
name: Gómez-Cañas, María
name: Burgaz, Sonia
name: Palomares, Belén
name: Gómez-Gálvez, Yolanda
name: Palomo-Garo, Cristina
name: Campo, Sara
name: Ferrer-Hernández, Joel
name: Pavicic, Carolina
name: Navarrete, Carmen
name: M. Luz Bellido
name: García-Arencibia, Moisés
name: M. Ruth Pazos
name: Muñoz, Eduardo
name: Fernández-Ruiz, Javier
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: BV2 cells were seeded at 1 × 105 in 60-mm dishes and 24 h later treated with RGZ or VCE-003.2 in the absence or the presence of LPS (50 ng/mL) for 6 h and the steady state levels of endogenous PPARγ and β-actin detected by western blot (PDF 105 kb)
Spectral sequences via examples
Creators: name: Ramos, Antonio Díaz
Publisher: name: arXiv
Year: 2017
Subjects: subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics
subject: 55T

description: These are lecture notes for a short course about spectral sequences that was held at Málaga, October 18--20 (2016), during the "Fifth Young Spanish Topologists Meeting". The approach was to illustrate the basic notions via fully computed examples arising from Algebraic Topology and Group Theory.
description: 31 pages
Additional file 4: of Rice NAC transcription factor ONAC066 functions as a positive regulator of drought and oxidative stress response
Creators: name: Yuan, Xi
name: Wang, Hui
name: Cai, Jiating
name: Bi, Yan
name: Li, Dayong
name: Song, Fengming
Publisher: name: figshare
Year: 2019
Subjects: Medicine
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Developmental Biology
Mental Health
Computational Biology

description: Table S1. Primers used in this study. (DOCX 16 kb)
Short divalent ethacrynic amides as pro-inhibitors of glutathione S-transferase isozyme Mu and potent sensitisers of cisplatin-resistant ovarian cancers
Creators: name: Xu, Bangtian
name: Tong, Tingting
name: Wang, Xin
name: Liu, Fang
name: Zhang, Xiang
name: Hu, Xiaolei
name: Li, Xinpeng
name: Yang, Xiaolan
name: Liao, Fei
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Virology

description: The linking of ethacrynic acid with ethylenediamine and 1,4-butanediamine gave EDEA and BDEA, respectively, as membrane-permeable divalent pro-inhibitors of glutathione S-transferase (GST). Their divalent glutathione conjugates showed subnanomolar inhibition and divalence-binding to GSTmu (GSTM) (PDB: 5HWL) at ∼0.35 min−1. In cisplatin-resistant SK-OV-3, COC1, SGC7901 and A549 cells, GSTM activities probed by 15 nM BDEA or EDEA revealed 5-fold and 1.0-fold increases in cisplatin-resistant SK-OV-3 and COC1 cells, respectively, in comparison with the susceptible parental cells. Being tolerable by HEK293 and LO2 cells, BDEA at 0.2 μM sensitised resistant SK-OV-3 and COC1 cells by ∼3- and ∼5-folds, respectively, released cytochrome c and increased apoptosis; EDEA at 1.0 μM sensitised resistant SK-OV-3 and A549 cells by ∼5- and ∼7-fold, respectively. EDEA at 1.7 μg/g sensitised resistant SK-OV-3 cells to cisplatin at 3.3 μg/g in nude mouse xenograft model. BDEA and EDEA are promising leads for probing cellular GSTM and sensitising cisplatin-resistant ovarian cancers.
Interaction of letrozole and its degradation products with aromatase: chemometric assessment of kinetics and structure-based binding validation
Creators: name: De Luca, Michele
name: Occhiuzzi, Maria Antonietta
name: Rizzuti, Bruno
name: Ioele, Giuseppina
name: Ragno, Gaetano
name: Garofalo, Antonio
name: Grande, Fedora
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Letrozole is one of the most prescribed drugs for the treatment of breast cancer in post-menopausal women, and it is endowed with selective peripheral aromatase inhibitory activity. The efficacy of this drug is also a consequence of its long-lasting activity, likely due to its metabolic stability. The reactivity of cyano groups in the letrozole structure could, however, lead to chemical derivatives still endowed with residual biological activity. Herein, the chemical degradation process of the drug was studied by coupling multivariate curve resolution and spectrophotometric methodologies in order to assess a detailed kinetic profile. Three main derivatives were identified after drug exposure to different degradation conditions, consisting of acid-base and oxidative environments and stressing light. Molecular docking confirmed the capability of these compounds to accommodate into the active site of the enzyme, suggesting that the sustained inhibitory activity of letrozole may be at least in part attributed to the degradation compounds.
title: Dos reacuñaciones romano-republicanas sobre moneda hispánica
title: Dos reacuñaciones romano-republicanas sobre moneda hispánica
titleType: Subtitle
Creators: name: Arévalo González, Alicia
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 38 (1997)
description: Folgt.
Additional file 1 of Establishment and validation of a prognostic model based on HRR-related lncRNAs in colon adenocarcinoma
Creators: name: Tang, Xingkui
name: Lin, Yukun
name: He, Jialin
name: Luo, Xijun
name: Liang, Junjie
name: Zhu, Xianjun
name: Li, Tao
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: Additional file 1: Supplementary Figure 1. Coexpression network between the nineteen HRR-related lncRNAs and HRR genes.
Radio Tomography for Roadside Surveillance
Creators: name: Anderson, Christopher R.
name: Martin, Richard K.
name: Walker, T. Owens
name: Thomas, Ryan W.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Radio tomographic imaging (RTI) has recently been proposed for tracking object location via radio waves without requiring the objects to transmit or receive radio signals. The position is extracted by inferring which voxels are obstructing a subset of radio links in a dense wireless sensor network. This paper proposes a variety of modeling and algorithmic improvements to RTI for the scenario of roadside surveillance. These include the use of a more physically motivated weight matrix, a method for mitigating negative (aphysical) data due to noisy observations, and a method for combining frames of a moving vehicle into a single image. The proposed approaches are used to show improvement in both imaging (useful for human-in-the-loop target recognition) and automatic target recognition in a measured data set.
description: http://ieeexplore.ieee.org/document/6644288/
title: Neue Überlegungen und eine neue Quelle zur Entstehung der althispanischen Schriften
title: Neue Überlegungen und eine neue Quelle zur Entstehung der althispanischen Schriften
titleType: Subtitle
Creators: name: Untermann, Jürgen
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: lala

description: Madrider Mitteilungen, Vol. 38 (1997)
description: Deutsche Zusammenfassung folgt.
Efficiently reducing transition curvature in heat-assisted magnetic recording with state-of-the-art write heads
Creators: name: Vogler, Christoph
name: Abert, Claas
name: Bruckner, Florian
name: Suess, Dieter
Publisher: name: arXiv
Year: 2017
Subjects: subject: Computational Physics (physics.comp-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The curvature of bit transitions on granular media is a serious problem for the read-back process. We address this fundamental issue and propose a possibility to efficiently reduce transition curvatures with state-of-the-art heat-assisted magnetic recording (HAMR) heads. We compare footprints of conventional with those of the proposed head design on different media, consisting of exchange coupled and single phase grains. Additionally, we investigate the impact of various recording parameters, like the full width at half maximum (FWHM) of the applied heat pulse and the coercivity gradient near the write temperature of the recording grains. The footprints are calculated with a coarse grained model, based on the Landau-Lifshitz-Bloch (LLB) equation. The presented simulations show a transition curvature reduction of up to 40 %, in the case of a medium with exchange coupled grains and a heat pulse with a FWHM of 40 nm. We further give the reason for the straightening of the bit transitions, by means of basic considerations with regard to the effective recording time window (ERTW) of the write process. Besides the transition curvature reduction the proposed head design yields an improvement of the transition jitter in both down-track and off-track direction.
Bouncing on Titan: Motion of the Huygens Probe in the Seconds After Landing
Creators: name: Schröder, Stefan E.
name: Karkoschka, Erich
name: Lorenz, Ralph D.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: While landing on Titan, several instruments onboard Huygens acquired measurements that indicate the probe did not immediately come to rest. Detailed knowledge of the probe's motion can provide insight into the nature of Titan's surface. Combining accelerometer data from the Huygens Atmospheric Structure Instrument (HASI) and the Surface Science Package (SSP) with photometry data from the Descent Imager/Spectral Radiometer (DISR) we develop a quantitative model to describe motion of the probe, and its interaction with the surface. The most likely scenario is the following. Upon impact, Huygens created a 12 cm deep hole in the surface of Titan. It bounced back, out of the hole onto the flat surface, after which it commenced a 30-40 cm long slide in the southward direction. The slide ended with the probe out of balance, tilted in the direction of DISR by around 10 degrees. The probe then wobbled back and forth five times in the north-south direction, during which it probably encountered a 1-2 cm sized pebble. The SSP provides evidence for movement up to 10 s after impact. This scenario puts the following constraints on the physical properties of the surface. For the slide over the surface we determine a friction coefficient of 0.4. While this value is not necessarily representative for the surface itself due to the presence of protruding structures on the bottom of the probe, the dynamics appear to be consistent with a surface consistency of damp sand. Additionally, we find that spectral changes observed in the first four seconds after landing are consistent with a transient dust cloud, created by the impact of the turbulent wake behind the probe on the surface. The optical properties of the dust particles are consistent with those of Titan aerosols from Tomasko et al. (P&SS 56, 669). We suggest that the surface at the landing site was covered by a dust layer, possibly the 7 mm layer of...
description: 31 pages, 14 figures