cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Autophagy Links Inflammasomes to Atherosclerotic Progression
Creators: name: Virgin, Herbert W.
name: Feng, Chu
name: Kastan, Michael B.
name: Coleman, Trey
name: Ting, Jenny P.
name: Semenkovich, Clay F.
name: Hwang, Seungmin
name: Wen, Haitao
name: Razani, Babak
name: Emanuel, Roy
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: We investigated the role of autophagy in atherosclerosis. During plaque formation in mice, autophagic markers co-localized predominantly with macrophages (mϕ). Atherosclerotic aortas had elevated levels of p62, suggesting that dysfunctional autophagy is characteristic of plaques. To determine if autophagy directly influences atherogenesis, we characterized Beclin-1 heterozygous-null and mϕ-specific ATG5-null (ATG5-mϕKO) mice, commonly used models of autophagy haploinsufficiency and deficiency, respectively. Haploinsufficent Beclin-1 mice had no atherosclerotic phenotype, but ATG5-mϕKO mice had increased plaques suggesting an essential role for basal levels of autophagy in atheroprotection. Defective autophagy is associated with pro-atherogenic inflammasome activation. Classic inflammasome markers were robustly induced in ATG5-null mϕ, especially when co-incubated with cholesterol crystals. Moreover, cholesterol crystals appear to be increased in ATG5-mϕKO plaques, suggesting a potentially vicious cycle of crystal formation and inflammasome activation in autophagy-deficient plaques. These results show that autophagy becomes dysfunctional in atherosclerosis and its deficiency promotes atherosclerosis in part through inflammasome hyperactivation.
Bicha space-time : queer and trans femme spatial practices in Sobral, Ceará
Creators: name: Rojas, Joseph Luis
Publisher: name: The University of Texas at Austin
Year: 2023
Subjects: Bicha
Brazilian Northeast
Cities
Drag
Femme
Forró
Queer space
Trans
Vogue

description: Despite prevailing stereotypes that construct the Brazilian Northeast and non-metropolitan urban spaces as anachronistic and conservative, queer and trans people in a growing number of cities such as Sobral, Ceará, have managed to project themselves onto local, regional, and (trans)national imaginaries. Inspired by Dora Silva Santana’s concept of Afro trans vivências, this thesis centers bicha vivências nordestinas (Northeastern bicha living), understood as the embodied knowledge and resistance of Northeastern queer and trans femmes. I follow a group of college-aged sobralenses primarily consisting of (effeminate) gay men, drag queens, and non-binary and transfeminine folks, and examine the ways in which they adeptly navigate and negotiate different parts of the city in an effort to appropriate spaces for queer and trans sociability. I argue that they queer or trans-form space in Sobral, producing what I call transient geographies, through public performances of femininity and gender nonconformity made possible by fleeting but recurring assemblages of queer people in relationship. I also narrate the embodiments and performances of Rawser, a non-binary gay drag queen who sings in the historically macho genre of forró, and Malika, a black trans artist who translocalizes cultural forms such as ballroom and slam poetry. I argue for techniques of transfemmation as a framework for understanding the methods or tactics by which ephemeral performances of femininity and gender non-conformity, such as those modeled by Rawser and Malika, may queer or trans-form space. Collectively, my interlocutors complicate standard depictions of the region, contest social norms, disrupt the expected uses of (symbolic) space, and demonstrate some of the creative ways in which queer and trans femme spatial practices work within, alongside, and against otherwise cisheteronormative geographies.
Genetic Control of Obesity and Gut Microbiota Composition in Response to High-Fat, High-Sucrose Diet in Mice
Creators: name: Org, Elin
name: Parks, Brian W.
name: Kirby, Mark
name: He, Aiqing
name: Pan, Calvin
name: Gargalovic, Peter
name: Bennett, Brian J.
name: Drevon, Christian A.
name: Knight, Rob
name: Nam, Elizabeth
name: Ursell, Luke K.
name: Eskin, Eleazar
name: Castellani, Lawrence W.
name: Lusis, Aldons J.
name: Mehrabian, Margarete
name: Rau, Christoph D.
name: Norheim, Frode
name: Drake, Thomas A.
name: Zinker, Bradley
name: Civelek, Mete
name: Kirchgessner, Todd
name: Kostem, Emrah
name: Hui, Simon T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Obesity is a highly heritable disease driven by complex interactions between genetic and environmental factors. Human genome-wide association studies (GWAS) have identified a number of loci contributing to obesity; however, a major limitation of these studies is the inability to assess environmental interactions common to obesity. Using a systems genetics approach, we measured obesity traits, global gene expression, and gut microbiota composition in response to a high-fat/high-sucrose (HF/HS) diet of more than 100 inbred strains of mice. Here we show that HF/HS feeding promotes robust, strain-specific changes in obesity that is not accounted for by food intake and provide evidence for a genetically determined set-point for obesity. GWAS analysis identified 11 genome-wide significant loci associated with obesity traits, several of which overlap with loci identified in human studies. We also show strong relationships between genotype and gut microbiota plasticity during HF/HS feeding and identify gut microbial phylotypes associated with obesity.
In Vivo HIF-Mediated Reductive Carboxylation Is Regulated by Citrate Levels and Sensitizes VHL-Deficient Cells to Glutamine Deprivation
Creators: name: Yang, Juanjuan
name: Wang, Zongwei
name: Olumi, Aria
name: López-Larrubia, Pilar
name: Arreola, Alexandra
name: Gameiro, Paulo A.
name: Metelo, Ana M.
name: Iliopoulos, Othon
name: Pérez-Carro, Rocio
name: Rathmell, W. Kimryn
name: Baker, Rania
name: Stephanopoulos, Gregory
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Hypoxic and VHL-deficient cells use glutamine to generate citrate and lipids through reductive carboxylation (RC) of α-ketoglutarate. To gain insights into the role of HIF and the molecular mechanisms underlying RC, we took advantage of a panel of disease-associated VHL mutants and showed that HIF expression is necessary and sufficient for the induction of RC in human renal cell carcinoma (RCC) cells. HIF expression drastically reduced intracellular citrate levels. Feeding VHL-deficient RCC cells with acetate or citrate or knocking down PDK-1 and ACLY restored citrate levels and suppressed RC. These data suggest that HIF-induced low intracellular citrate levels promote the reductive flux by mass action to maintain lipogenesis. Using [1–13C] glutamine, we demonstrated in vivo RC activity in VHL-deficient tumors growing as xenografts in mice. Lastly, HIF rendered VHL-deficient cells sensitive to glutamine deprivation in vitro, and systemic administration of glutaminase inhibitors suppressed the growth of RCC cells as mice xenografts.
Reserva Pacuare, CR
Creators: name: Schimelpfenig, David
name: Manager Reserva Pacuare
Publisher: name: figshare
Year: 2020
Subjects: subject: 50202 Conservation and Biodiversity
subject: FOS: Biological sciences
subject: Ecology
subject: 50203 Environmental Education and Extension
subject: FOS: Earth and related environmental sciences
subject: Environmental Science
subject: 50209 Natural Resource Management
subject: 60202 Community Ecology (excl. Invasive Species Ecology)
subject: 60299 Ecology not elsewhere classified
subject: Marine Biology
subject: 60205 Marine and Estuarine Ecology (incl. Marine Ichthyology)

description: Established in 1989 and administered by Ecology Project International (EPI) since 2016, Reserva Pacuare encompasses 800 hectares of tropical rainforest on the Caribbean coast of Costa Rica with 6km of coastline. It hosts a high density of wildlife, is the most important nesting beach in the country for the leatherback sea turtles, and is habitat to the only accessible breeding colony of Agami herons in the Caribbean, North, Central and northern South America regions. Reserva Pacuare is managed to promote conservation, research and environmental education.

Contact Reserva Pacuare (https://www.pacuarereserve.org) for information regarding access, data sharing, use of facilities, or research opportunities).

(10.168 N, 83.235 W)
www.ecologyproject.org
Cytoplasmic Ig-domain proteins: Cytoskeletal regulators with a role in human disease
Creators: name: Otey, Carol A.
name: Goicoechea, Silvia M.
name: Stack, Christianna
name: Dixon, Richard
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Immunoglobulin domains are found in a wide variety of functionally diverse transmembrane proteins, and also in a smaller number of cytoplasmic proteins. Members of this latter group are usually associated with the actin cytoskeleton, and most of them bind directly to either actin or myosin, or both. Recently, studies of inherited human disorders have identified disease-causing mutations in five cytoplasmic Ig-domain proteins: myosin-binding protein C, titin, myotilin, palladin, and myopalladin. Together with results obtained from cultured cells and mouse models, these clinical studies have yielded novel insights into the unexpected roles of Ig domain proteins in mechanotransduction and signaling to the nucleus. An emerging theme in this field is that cytoskeleton-associated Ig domain proteins are more than structural elements of the cell, and may have evolved to fill different needs in different cellular compartments.
title: Is it possible to recover the visual assessment of BI-RADS classification based on MRI using radiomic features?
Creators: name: Saint Martin, Marie-Judith
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Artificial Intelligence
subject: Breast
subject: MR
subject: Computer Applications-Detection, diagnosis
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: BI-RADS (Breast Imaging-Reporting and Data System) [1] provides radiologists with a widely recognised lexicon to assess breast mammography, ultrasound and MRI studies. In patients diagnosed with locally advanced breast cancer and who underwent...
Developmental regulation of calmodulin-dependent adenylate cyclase activity in an insect endocrine gland.
Creators: name: Meller, Victoria
name: Gilbert, Lawrence I.
name: Sakurai, Sho
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: The insect prothoracic gland produces ecdysteroids that elicit molting and metamorphosis, and neurohormone stimulation of steroidogenesis by this gland involves both Ca2+ and cyclic adenosine monophosphate second messengers. Prothoracic gland adenylate cyclase exhibits a complex Ca2+/calmodulin (CaM) dependence, a component of which requires an activated Gs alpha for expression. A developmental switch in this system has been identified that correlates with a change in both regulation and function of the gland and involves the loss of sensitivity to extracellular Ca2+ at a time approximately concurrent with the loss of Ca2+/CaM sensitivity by the adenylate cyclase. The extent of cholera toxin activation of gland Gs alpha is lowered before this developmental switch. However, no alterations in Gs alpha levels or mobility are detected, suggesting that Gs alpha interaction with another component in the signaling pathway, perhaps adenylate cyclase itself, produces the apparent Ca2+/CaM dependence and influences the ability of toxin to modify Gs alpha.
Probing the end of reionization with the near-zones of z > 6 QSOs
Creators: name: Keating, Laura C.
name: Haehnelt, Martin G.
name: Cantalupo, Sebastiano
name: Puchwein, Ewald
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: QSO near-zones are an important probe of the the ionization state of the IGM at z ~ 6-7, at the end of reionization. We present here high-resolution cosmological 3D radiative transfer simulations of QSO environments for a wide range of host halo masses, 10$^{10-12.5}$ M_sun. Our simulated near-zones reproduce both the overall decrease of observed near-zone sizes at 6 < z < 7 and their scatter. The observable near-zone properties in our simulations depend only very weakly on the mass of the host halo. The size of the H II region expanding into the IGM is generally limited by (super-)Lyman Limit systems loosely associated with (low-mass) dark matter haloes. This leads to a strong dependence of near-zone size on direction and drives the large observed scatter. In the simulation centred on our most massive host halo, many sightlines show strong red damping wings even for initial volume averaged neutral hydrogen fractions as low as ~ 10$^{-3}$. For QSO lifetimes long enough to allow growth of the central supermassive black hole while optically bright, we can reproduce the observed near-zone of ULAS J1120+0641 only with an IGM that is initially neutral. Our results suggest that larger samples of z > 7 QSOs will provide important constraints on the evolution of the neutral hydrogen fraction and thus on how late reionization ends.
description: This is a pre-copyedited, author-produced PDF of an article accepted for publication in MNRAS following peer review. 19 pages, 17 figures and 3 tables
Presynaptic release regulating metabotropic receptors: dimerization and receptor cross talk
Creators: name: VERGASSOLA, MATTEO
Publisher: name: Universit� degli studi di Genova
Year: 2020

description: The Class C subfamily of the G protein coupled receptor (GPCR) family is one of the most important in the central nervous system (CNS), and includes the glutamatergic and GABAergic metabotropic receptors (mGlu and GABAB). The mGlu receptors are fundamental in modulating the efficiency of chemical neurotransmission in the CNS and, as a consequence, they are also involved in several neurological and neurodegenerative disorders. Recently, dimerization of these receptors has become an important topic of investigation and it has been proposed to be crucial to physio-pathological processes in the CNS, as well as to the impact of therapeutics in patients. In this thesis, I will discuss the basic properties of Class C GPCRs focusing on the first and second group of mGlu receptors (Group I and II) and their possible dimerization and/or cross talk with other receptors. I will focus on recent findings concerning these processes that have been mainly obtained by using purified isolated nerve endings (here referred to as synaptosomes), a subcellular preparation of choice for studying presynaptic release regulating receptors. Starting from the pharmacological characterization of Group I and II mGlu receptors, I will then discuss different examples of cross-talk linking these receptors to other ones (i.e. the GABAB and the 5HT2A receptors). I will also show results obtained using electrophysiology to study the role of these receptor subtypes in the modulation of synaptic transmission in hippocampal slices. The resulting picture is undoubtedly complex and highlights how the cross-talk and dimerization of these receptors represent a new frontier in neuropharmacological studies.
How the transition frequencies of microtubule dynamic instability (nucleation, catastrophe, and rescue) regulate microtubule dynamics in interphase and mitosis: analysis using a Monte Carlo computer simulation.
Creators: name: Gliksman, N. R.
name: Skibbens, R. V.
name: Salmon, E. D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: Microtubules (MTs) in newt mitotic spindles grow faster than MTs in the interphase cytoplasmic microtubule complex (CMTC), yet spindle MTs do not have the long lengths or lifetimes of the CMTC microtubules. Because MTs undergo dynamic instability, it is likely that changes in the durations of growth or shortening are responsible for this anomaly. We have used a Monte Carlo computer simulation to examine how changes in the number of MTs and changes in the catastrophe and rescue frequencies of dynamic instability may be responsible for the cell cycle dependent changes in MT characteristics. We used the computer simulations to model interphase-like or mitotic-like MT populations on the basis of the dynamic instability parameters available from newt lung epithelial cells in vivo. We started with parameters that produced MT populations similar to the interphase newt lung cell CMTC. In the simulation, increasing the number of MTs and either increasing the frequency of catastrophe or decreasing the frequency of rescue reproduced the changes in MT dynamics measured in vivo between interphase and mitosis.
(401649) Unkown [Macintosh]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Aortoenteric fistula: Keys to the diagnosis of an increasingly less prevalent but fatal entity.
Creators: name: Cobo Ruiz, Teresa
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Arteries / Aorta
subject: Gastrointestinal tract
subject: CT
subject: CT-Angiography
subject: Contrast agent-intravenous
subject: Diagnostic procedure
subject: Fistula
subject: Grafts
subject: Haemorrhage

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To assess the importance of a prompt emergency diagnosis using CT in patients with aortoenteric fistula, a rare but life-threatening condition. To define and describe the concept and types of aortoenteric fistulas as well as their differences. To...
Observation of Floquet states in a strongly driven artificial atom
Creators: name: Deng, Chunqing
name: Orgiazzi, Jean-Luc
name: Shen, Feiruo
name: Ashhab, Sahel
name: Lupascu, Adrian
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We present experiments on the driven dynamics of a two-level superconducting artificial atom. The driving strength reaches 4.78 GHz, significantly exceeding the transition frequency of 2.288 GHz. The observed dynamics is described in terms of quasienergies and quasienergy states, in agreement with Floquet theory. In addition, we observe the role of pulse shaping in the dynamics, as determined by non-adiabatic transitions between Floquet states, and we implement subnanosecond single-qubit operations. These results pave the way to quantum control using strong driving with applications in quantum technologies.
Suppression of yeast geranylgeranyl transferase I defect by alternative prenylation of two target GTPases, Rho1p and Cdc42p.
Creators: name: Botstein, David
name: Qadota, Hiroshi
name: Anraku, Yasuhiro
name: Ohya, Yoshikazu
name: Pringle, John R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: Geranylgeranyl transferase I (GGTase I), which modifies proteins containing the sequence Cys-Ali-Ali-Leu (Ali: aliphatic) at their C-termini, is indispensable for growth in the budding yeast Saccharomyces cerevisiae. We report here that GGTase I is no longer essential when Rho1p and Cdc42p are simultaneously overproduced. The lethality of a GGTase I deletion is most efficiently suppressed by provision of both Rho1p and Cdc42p with altered C-terminal sequences (Cys-Ali-Ali-Met) corresponding to the C-termini of substrates of farnesyl transferase (FTase). Under these circumstances, the FTase, normally not essential for growth of yeast, becomes essential.
U.S. Food Expenditures, 1954-1978: New Measures at Point of Sale and by Type of Purchaser
Creators: name: Manchester, Alden C.
name: King, Richard A.
name: Manchester, Alden C.
name: King, Richard A.
Publisher: name: Unknown
Year: 1979
Subjects: subject: Food Consumption/Nutrition/Food Safety
subject: Research Methods/ Statistical Methods
subject: Food sales
subject: food expenditures
subject: food retailers

description: The series currently used to estimate food expenditures yield incomplete and often conflicting data. The new series described here is more comprehensive. Called the total expenditures series, it reports total U.S. food sales by all retailers of food consumed both on- and off-premises. The series also includes food provided to military personnel, and food served in hospitals, institutions, and schools, where separate sales figures for food are unavailable. The series separates the total figures by different types of sellers and different food categories and provides estimates of total U.S. food expenditures between 1954 and 1978.
Magnetized color superconducting cold quark matter within the SU(2)$_f$ NJL model: a novel regularization scheme
Creators: name: Allen, Pablo G.
name: Grunfeld, Ana G.
name: Scoccola, Norberto N.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The influence of intense magnetic fields on the behavior of color superconducting cold quark matter is investigated using an SU(2)$_f$ NJL-type model for which a novel regulation scheme is introduced. In such a scheme the contributions which are explicitly dependent on the magnetic field turn out to be finite and, thus, do not require to be regularized. As a result of this, nonphysical oscillations that might arise in the alternative regularization schemes previously used in the literature are naturally removed. The sensitivity of our results to the model parametrization is analyzed.
description: 28 pages, 7 figures
Il punto di vista degli insegnanti. Il ruolo di belief e barriere nell'integrazione delle tecnologie nella didattica delle lingue.
Creators: name: VAGO, VALERIA
Publisher: name: Universit� degli studi di Genova
Year: 2020

description: Fissando quali obiettivi di ricerca lo scarso utilizzo di tecnologia nella didattica delle lingue straniere nella scuola secondaria di secondo grado e la possibilit� che la Dirigenza Scolastica possa esserne la causa, � stato selezionato un campione di docenti di due scuole al quale � stato proposto un questionario riguardante belief (l?insieme delle convinzioni, dei pensieri e delle opinioni) e barriere (tutto ci� che comporta la presenza di ostacoli all?introduzione delle tecnologie nella didattica) che ha esplorato il punto di vista dei professori in merito all?introduzione, all?uso e all?utilit� delle tecnologie nella didattica delle lingue. I risultati hanno portato ad eliminare la Dirigenza dai possibili fattori che limiterebbero l?uso di TIC nella didattica spostando l?attenzione sulle scelte personali dei docenti circa le loro convinzioni ed esperienze professionali personali.
(401645) Elizabeth Malcolm
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: CEUS: Characterization of focal liver lesions
Creators: name: Pérez Termenón, Alicia
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Ultrasound
subject: Contrast agent-other
subject: Metastases

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To review the principles of contrast enchanced ultrasound To review typical characteristic appearance of focal liver lesions in CEUS To illustrate and review cases of our clinical...
Giant and tunable valley degeneracy splitting in MoTe2
Creators: name: Qi, Jingshan
name: Li, Xiao
name: Niu, Qian
name: Feng, Ji
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Monolayer transition-metal dichalcogenides possess a pair of degenerate helical valleys in the band structure that exhibit fascinating optical valley polarization. Optical valley polarization, however, is limited by carrier lifetimes of these materials. Lifting the valley degeneracy is therefore an attractive route for achieving valley polarization. It is very challenging to achieve appreciable valley degeneracy splitting with applied magnetic field. We propose a strategy to create giant splitting of the valley degeneracy by proximity-induced Zeeman effect. As a demonstration, our first principles calculations of monolayer MoTe$_2$ on a EuO substrate show that valley splitting over 300 meV can be generated. The proximity coupling also makes interband transition energies valley dependent, enabling valley selection by optical frequency tuning in addition to circular polarization. The valley splitting in the heterostructure is also continuously tunable by rotating substrate magnetization. The giant and tunable valley splitting adds a readily accessible dimension to the valley-spin physics with rich and interesting experimental consequences, and offers a practical avenue for exploring device paradigms based on the intrinsic degrees of freedom of electrons.
description: 8 pages, 5 figures, 1 table
Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells.
Creators: name: Turner, Christopher E.
name: McLean, Natalie
name: Burridge, Keith
name: Romer, Lewis H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1994

description: Tyrosine phosphorylation of cytoskeletal proteins occurs during integrin-mediated cell adhesion to extracellular matrix proteins. We have investigated the role of tyrosine phosphorylation in the migration and initial spreading of human umbilical vein endothelial cells (HUVEC). Elevated phosphotyrosine concentrations were noted in the focal adhesions of HUVEC migrating into wounds. Anti-phosphotyrosine Western blots of extracts of wounded HUVEC monolayers demonstrated increased phosphorylation at 120-130 kDa when compared with extracts of intact monolayers. The pp125FAK immunoprecipitated from wounded monolayers exhibited increased kinase activity as compared to pp125FAK from intact monolayers. The time to wound closure in HUVEC monolayers was doubled by tyrphostin AG 213 treatment. The same concentration of AG 213 interfered with HUVEC focal adhesion and stress fiber formation. AG 213 inhibited adhesion-associated tyrosine phosphorylation of pp125FAK in HUVEC. Tyrphostins AG 213 and AG 808 inhibited pp125FAK activity in in vitro kinase assays. pp125FAK immunoprecipitates from HUVEC treated with both of these inhibitors also had kinase activity in vitro that was below levels seen in untreated HUVEC. These findings suggest that tyrosine phosphorylation of cytoskeletal proteins may be important in HUVEC spreading and migration and that pp125FAK may mediate phosphotyrosine formation during these processes.
Health Impact of Air Pollution from Shipping in the Baltic Sea: Effects of Different Spatial Resolutions in Sweden-Supplementary material
Creators: name: Mwase, Nandi
name: Ekström, Alicia
name: Jonson, Jan Eiof
name: Svensson, Erik
name: Jalkanen, Juka-Pekka
name: Wichmann, Janine
name: Molnár, Peter
name: Stockfelt, Leo
Publisher: name: Zenodo
Year: 2020

description: This is supplementary material for the article submission entitled,"Health Impact of Air Pollution from Shipping in the Baltic Sea: Effects of Different Spatial Resolutions in Sweden" to the International Journal of Environmental Research and Public Health.
(401646) John Malcolm
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Computer analysis of the binding reactions leading to a transmembrane receptor-linked multiprotein complex involved in bacterial chemotaxis.
Creators: name: Bourret, Robert B.
name: Bray, Dennis
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: The chemotactic response of bacteria is mediated by complexes containing two molecules each of a transmembrane receptor and the intracellular signaling proteins CheA and CheW. Mutants in which one or the other of the proteins of this complex are absent, inactive, or expressed at elevated amounts show altered chemotactic behavior and the phenotypes are difficult to interpret for some overexpression mutants. We have examined the possibility that these unexpected phenotypes might arise from the binding steps that lead to active complex formation. A limited genetic algorithm was used to search for sets of binding reactions and associated binding constants expected to give mutant phenotypes in accord with experimental data. Different sets of binding equilibria and different assumptions about the activity of particular receptor complexes were tried. Computer analysis demonstrated that it is possible to obtain sets of binding equilibria consistent with the observed phenotypes and provided a simple explanation for these phenotypes in terms of the distribution of active and inactive complexes formed under various conditions. Optimization methods of this kind offer a unique way to analyze reactions taking place inside living cells based on behavioral data.
"SAMIMIYAT" UMUMIY MA'NOLI MAQOLLARNING SEMANTIK XUSUSIYATI
Creators: name: Sayfullayeva, Fotima
Publisher: name: Zenodo
Year: 2023

description: Ushbu maqolada "samimiyat" umumiy ma'noli maqollarning semantik xususiyatlari, ularning semantik tizimi o'rganildi. "Ma'naviyat" leksik-semantik kategoriyasining "samimiyat" umumiy ma'noli birliklari o'quvchilarda shaxs ma'naviy sifatlarining takomillashuvi va tarbiyaviy ahamiyatiga ta'siri maqollar tahlili orqali amalga oshirilgan.
Force Generation by Microtubule Assembly/Disassembly in Mitosis and Related Movements
Creators: name: Salmon, Edward D.
name: Inoué, Shinya
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: In this article, we review the dynamic nature of the filaments (microtubules) that make up the labile fibers of the mitotic spindle and asters, we discuss the roles that assembly and disassembly of microtubules play in mitosis, and we consider how such assembling and disassembling polymer filaments can generate forces that are utilized by the living cell in mitosis and related movements.
title: O-RADS MRI: how the radiologist can help in decision-making process in patients with ovarian masses
Creators: name: Konidari, Maria Anna
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Genital / Reproductive system female
subject: Pelvis
subject: MR
subject: Diagnostic procedure
subject: Cancer
subject: Cysts
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To provide radiologists with a comprehensive review regarding the O-RADS MRI classification system and enable them to use it in daily practice in order to characterize adnexal masses. To understand the O-RADS MRI features using typical cases as a...
Developments in Marketing Spreads for Food Products in 1979
Creators: name: Dunham, Denis
name: Dunham, Denis
Publisher: name: Unknown
Year: 1980
Subjects: subject: Food Consumption/Nutrition/Food Safety
subject: Marketing
subject: FOS: Economics and business
subject: Production Economics
subject: Food prices
subject: Farm values
subject: Price spreads
subject: Marketing costs
subject: Food expenditures

description: Retail food prices in grocery stores were 10.8 percent higher in 1979 than in 1978. The largest Increase was for red meat, up 17 percent, reflecting a 24-percent increase in Choice beef prices. Higher farm values for food commodities, up 11.4 percent, accounted for a third of the increase. The spread between farm and retail prices (representing charges made for processing; and distributing foods after they leave the farm) was 11.9 percent wider and accounted for slightly over half the food price increase. Higher prices for fish and imported foods accounted for the remainder of the increase.
(401647) James Robert Malcolm
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Integrin alpha 5 beta 1 expression negatively regulates cell growth: reversal by attachment to fibronectin.
Creators: name: Varner, Judith A.
name: Juliano, Rudolph L.
name: Emerson, David A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: Cells selected for overexpression of the integrin alpha 5 beta 1 show decreased proliferation and loss of the transformed phenotype. We provide evidence that de novo expression of the integrin alpha 5 beta 1 in HT29 colon carcinoma cells results in the growth arrest of these cells as characterized by reduced DNA synthesis and cellular proliferation in vitro. In fact, expression of integrin alpha 5 beta 1 on these cells induces the transcription of growth arrest specific gene 1 (gas-1), a gene product known to induce cellular quiescence, but blocks transcription of the immediate early genes c-fos, c-jun, and jun B. In vivo, the alpha 5 beta 1 transfectants display dramatically reduced tumorigenicity as well as a highly differentiated phenotype when compared with their pSVneo-transfected counterparts. Surprisingly, ligation of alpha 5 beta 1 on these cells by cell attachment to a fibronectin substrate not only reverses the growth inhibition and gas-1 gene induction but activates immediate early gene transcription. These findings demonstrate that integrin alpha 5 beta 1 expression in the absence of attachment to fibronectin activates a signaling pathway leading to decreased cellular proliferation and that ligation of this receptor with fibronectin reverses this signal, thereby contributing to the proliferation of transformed cells.
title: CT evaluation of ventricular assist devices (VADs)
Creators: name: Mursic, Miroslav
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Cardiac
subject: CT
subject: Education
subject: Cardiac Assist Devices

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To familiarize radiologists with morphology, function and types of VADs, and to evaluate possible complications with...
La pensosit� infantile nell'immaginario della letteratura e della filosofia
Creators: name: BEVILACQUA, SILVIA
Publisher: name: Universit� degli studi di Genova
Year: 2021

description: Questa ricerca � frutto di diversi anni di pratica di philosophy for children/community. Lo scritto non parla di queste esperienze, ma proprio da esse sorge l?idea fare ricerca nell?immaginario della pensosit� infantile letteraria e filosofica. Consapevoli che, come sostiene J-L Nancy, il pensiero non � il soggetto che pone davanti a s� un oggetto da esaminare e valutare. Questa ricerca e lo scritto che ne deriva � un organismo complesso: 1. Ogni capitolo contiene alcune citazioni da ritenersi fuori opera nella misura in cui sollecitano riflessioni a prescindere dal corpo del testo principale. 2. Le illustrazioni non sono tratte dalle opere citate nelle mitografie, ma sono testo. 3. L?abecedario delle figure metodologiche ha lo scopo di introdurre alla metodologia di questa ricerca filosofica. 4. Le mitografie sono l?esito della ricerca stessa intorno alla pensosit� infantile nel territorio della letteratura, come territorio da esplorare. La pensosit� infantile non � da intendersi solo come spazio di ricerca, ma soggetto e al tempo stesso modo di pensiero. Potremmo indicare questa idea di pensiero come perturbante, irreale, dubitante, aderente, aurorale, sotterranea, aerea o addirittura magica, ma quel che balza agli occhi � il suo effetto straniante che rappresenta il senso e la ragione per cui essa sia una possibile direzione, non trascurabile, nell?ambito della ricerca sui processi culturali e sulle migrazioni. La pensosit� infantile � al centro di questa ricerca filosofica, in particolare, nel suo sviluppo nell?immaginario letterario e filosofico.
Constructions and Noise Threshold of Hyperbolic Surface Codes
Creators: name: Breuckmann, Nikolas P.
name: Terhal, Barbara M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We show how to obtain concrete constructions of homological quantum codes based on tilings of 2D surfaces with constant negative curvature (hyperbolic surfaces). This construction results in two-dimensional quantum codes whose tradeoff of encoding rate versus protection is more favorable than for the surface code. These surface codes would require variable length connections between qubits, as determined by the hyperbolic geometry. We provide numerical estimates of the value of the noise threshold and logical error probability of these codes against independent X or Z noise, assuming noise-free error correction.
Eggplant-Derived Biochar-Halloysite Nanocomposite as Supports of Pd Nanoparticles for the Catalytic Hydrogenation of Nitroarenes in the Presence of Cyclodextrin
Creators: name: Heravi, Majid Mommahed
Publisher: name: figshare
Year: 2020
Subjects: subject: 30302 Nanochemistry and Supramolecular Chemistry
subject: FOS: Chemical sciences
subject: 30502 Natural Products Chemistry
subject: 30205 Non-metal Chemistry
subject: Nuclear Chemistry
subject: 30303 Optical Properties of Materials
subject: Organic Chemistry
subject: 30503 Organic Chemical Synthesis
subject: 30599 Organic Chemistry not elsewhere classified
subject: 30504 Organic Green Chemistry
subject: 39904 Organometallic Chemistry
subject: 30699 Physical Chemistry not elsewhere classified

description: A novel halloysite-hydrochar nanocomposite has been prepared and applied for the immobilization of Pd NPs to furnish an efficient catalyst for the hydrogenation of nitroarenes. It was confirmed that use of a catalytic amount of β-cyclodextrin (β-CD) could improve the yield of the reaction significantly. With the aim of investigation of the effect of combination of Hal and Char, Char surface modification, and the way of use of β-CD on the catalytic activity, several control catalysts were prepared and their catalytic activities were compared with that of the catalyst. It was confirmed that the use of Hal-Char as a support was more effective than the use of each component individually. Moreover, the use of β-CD in its free form was more efficient than incorporating it to the framework of the catalyst or as a capping agent. It was also found that Char in its unmodified form was more efficient than modified ones. To justify the results, a precise study was carried out by comparing the average Pd particle size and loading of each samples. It was confirmed that the Pd particle size and dispersion effectively affected the catalytic activity. Additionally, β-CD amount was a key factor for achieving high catalytic activity.
title: Hypersensitivity Pneumonitis: Radiological Findings and diagnostic criteria in the light of ATS/JRS/ALAT 2020 Guideline
Creators: name: Pérez Termenón, Alicia
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Lung
subject: Thorax
subject: CT
subject: Diagnostic procedure
subject: Pathology

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To describe the most recent hypersensitivity pneumonitis diagnostic criteria To illustrate the radiological findings in fibrotic and non fibrotic HP To summarize the recommendations formulated by the...
PT-symmetric Rabi model: Perturbation theory
Creators: name: Lee, Tony E.
name: Joglekar, Yogesh N.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We study a non-Hermitian version of the Rabi model, where a two-level system is periodically driven with an imaginary-valued drive strength, leading to alternating gain and loss. In the Floquet picture, the model exhibits PT symmetry, which can be broken when the drive is sufficiently strong. We derive the boundaries of the PT phase diagram for the different resonances by doing perturbation theory beyond the rotating-wave approximation. For the main resonance, we show that the non-Hermitian analog of the Bloch-Siegert shift corresponds to maximal PT-breaking. For the higher-order resonances, we capture the boundaries to lowest order. We also solve the regime of high frequency by mapping to the Wannier-Stark ladder. Our model can be experimentally realized in waveguides with spatially-modulated loss or in atoms with time-modulated spontaneous decay.
description: 8 pages, 6 figures
(401641) William Forest Malcolm
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(401643) William Aitken
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Imposed Magnetic Field and Hot Electron Propagation in Inertial Fusion Hohlraums
Creators: name: Strozzi, D. J.
name: Perkins, L. J.
name: Marinak, M. M.
name: Larson, D. J.
name: Koning, J. M.
name: Logan, B. G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: The effects of an imposed, axial magnetic field $B_{z0}$ on hydrodynamics and energetic electrons in inertial confinement fusion (ICF) indirect-drive hohlraums are studied. We present simulations from the radiation-hydrodynamics code HYDRA of a low-adiabat ignition design for the National Ignition Facility (NIF), with and without $B_{z0}=70$ Tesla. The field's main hydrodynamic effect is to significantly reduce electron thermal conduction perpendicular to the field. This results in hotter and less dense plasma on the equator between the capsule and hohlraum wall. The inner laser beams experience less inverse bremsstrahlung absorption before reaching the wall. The x-ray drive is thus stronger from the equator with the imposed field. We study superthermal, or "hot," electron dynamics with the particle-in-cell code ZUMA, using plasma conditions from HYDRA. During the early-time laser picket, hot electrons based on two-plasmon decay in the laser entrance hole (Regan et al., Phys. Plasmas 2010) are guided to the capsule by a 70 T field. 12x more energy deposits in the deuterium-tritium (DT) fuel. For plasma conditions early in peak laser power, we present mono-energetic test-case studies with ZUMA, as well as sources based on inner-beam stimulated Raman scattering. The effect of the field on DT deposition depends strongly on the source location, namely whether hot electrons are generated on field lines that connect to the capsule.
description: 21 pages. Submitted to Journal of Plasma Physics. Revised version
(401644) David Malcolm
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.