title: ÐÐ»Ð¸ÑÐ½Ð¸Ðµ Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸Ñ ÑÐµÑÐµÐ±ÑÐ° Ð½Ð° ÑÐ¾ÑÑ Ð°ÑÑÐ¸ÑÐ½Ð¾Ð¹ ÑÐ¾ÑÐ¼Ñ Ð°Ð´ÐµÐ½Ð¾ÐºÐ°ÑÑÐ¸Ð½Ð¾Ð¼Ñ Ð­ÑÐ»Ð¸Ñ Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: The influence of silver nanoparticles on the growth of the ascitic form of Ehrlichs adenocarcinoma
Creators: name: Ð ÐµÐºÐ¸Ð½Ð°, ÐÐ°Ð»ÐµÑÐ¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2023
Subjects: Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸ÑÑ ÑÐµÑÐµÐ±ÑÐ°
ÑÑÐ°ÑÑÑ Ð¼ÐµÐ´Ð¸
Ð°Ð´ÐµÐ½Ð¾ÐºÐ°ÑÑÐ¸Ð½Ð¾Ð¼Ð° Ð­ÑÐ»Ð¸Ñ Ð°
Ð¼ÐµÑÐ°Ð±Ð¾Ð»Ð¸Ð·Ð¼ Ð¼ÐµÐ´Ð¸
ÑÐºÐ¾ÑÐ¾ÑÑÑ ÑÐ¾ÑÑÐ° Ð¾Ð¿ÑÑ Ð¾Ð»Ð¸
silver nanoparticles
the status of copper
Ehrlichs adenocarcinoma
copper metabolism
tumor growth rate

description: Ð Ð¿Ð¾ÑÐ»ÐµÐ´Ð½Ð¸Ðµ Ð³Ð¾Ð´Ñ Ð½Ð°ÐºÐ¾Ð¿Ð»ÐµÐ½Ð¾ Ð±Ð¾Ð»ÑÑÐ¾Ðµ ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²Ð¾ Ð´Ð°Ð½Ð½ÑÑ, ÑÐºÐ°Ð·ÑÐ²Ð°ÑÑÐ¸Ñ Ð½Ð° Ð°ÐºÑÐ¸Ð²Ð½Ð¾Ðµ ÑÑÐ°ÑÑÐ¸Ðµ Ð¼ÐµÐ´Ð¸ Ð² ÑÐ¾ÑÑÐµ Ð¸ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ð¸ Ð¾Ð¿ÑÑÐ¾Ð»ÐµÐ¹, Ð² ÑÐ²ÑÐ·Ð¸ Ñ ÑÐµÐ¼ ÑÐ²Ð»ÑÐµÑÑÑ Ð°ÐºÑÑÐ°Ð»ÑÐ½ÑÐ¼ Ð¿Ð¾Ð¸ÑÐº Ð±ÐµÐ·Ð¾Ð¿Ð°ÑÐ½ÑÑ Ð¿ÑÑÐµÐ¹ ÑÐ½Ð¸Ð¶ÐµÐ½Ð¸Ñ ÑÑÐ°ÑÑÑÐ° Ð¼ÐµÐ´Ð¸ Ð² Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð¼Ðµ Ð² ÐºÐ°ÑÐµÑÑÐ²Ðµ Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð¾Ð¿ÑÑÐ¾Ð»ÐµÐ²Ð¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸. ÐÑÐµÐ´Ð¿Ð¾Ð»Ð¾Ð¶Ð¸ÑÐµÐ»ÑÐ½Ð¾, ÑÑÐ¾ Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½Ð¾ Ð·Ð° ÑÑÐµÑ Ð²Ð²ÐµÐ´ÐµÐ½Ð¸Ñ Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸Ñ ÑÐµÑÐµÐ±ÑÐ°, Ð¾Ð´Ð½Ð°ÐºÐ¾ ÑÐ¾ÑÐ½Ð¾Ð³Ð¾ Ð¼ÐµÑÐ°Ð½Ð¸Ð·Ð¼Ð° Ð¸Ñ Ð²Ð»Ð¸ÑÐ½Ð¸Ñ Ð½Ð° Ð·Ð°Ð¼ÐµÐ´Ð»ÐµÐ½Ð¸Ðµ Ð¿ÑÐ¾Ð³ÑÐµÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¾Ð¿ÑÑÐ¾Ð»ÐµÐ¹ Ð½Ðµ ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð¾. ÐÐ¾ÑÑÐ¾Ð¼Ñ ÑÐµÐ»ÑÑ Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ Ð±ÑÐ»Ð¾ Ð¸Ð·ÑÑÐµÐ½Ð¸Ðµ Ð²Ð»Ð¸ÑÐ½Ð¸Ñ Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸Ñ ÑÐµÑÐµÐ±ÑÐ° Ð½Ð° ÑÐ¾ÑÑ Ð°ÑÑÐ¸ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÐºÐ°ÑÑÐ¸Ð½Ð¾Ð¼Ñ Ð­ÑÐ»Ð¸ÑÐ°. ÐÐ»Ñ ÐºÐ°Ð¶Ð´Ð¾Ð¹ Ð¸ÑÑÐ»ÐµÐ´ÑÐµÐ¼Ð¾Ð¹ Ð³ÑÑÐ¿Ð¿Ñ Ð±ÑÐ» Ð²ÑÐ±ÑÐ°Ð½ ÑÐ²Ð¾Ð¹ Ð¿ÑÐ¾ÑÐ¾ÐºÐ¾Ð» Ð»ÐµÑÐµÐ½Ð¸Ñ Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸ÑÐ°Ð¼Ð¸, ÑÐ°Ð·Ð»Ð¸ÑÐ¸Ñ Ð¼ÐµÐ¶Ð´Ñ Ð½Ð¸Ð¼Ð¸ Ð±ÑÐ»Ð¸ Ð² ÑÑÐ¾ÐºÐ°Ñ Ð½Ð°ÑÐ°Ð»Ð° Ð¸ Ð¿ÑÐ¾Ð´Ð¾Ð»Ð¶Ð¸ÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ Ð²Ð²ÐµÐ´ÐµÐ½Ð¸Ñ Ð¸Ð½ÑÐµÐºÑÐ¸Ð¹. ÐÐ½ÑÑÑÐ¸Ð±ÑÑÑÐ¸Ð½Ð½Ð¾Ðµ Ð²Ð²ÐµÐ´ÐµÐ½Ð¸Ðµ Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸Ñ ÑÐµÑÐµÐ±ÑÐ°, ÐºÐ¾ÑÐ¾ÑÐ¾Ðµ Ð±ÑÐ»Ð¾ Ð½Ð°ÑÐ°ÑÐ¾ Ð¾Ð´Ð½Ð¾Ð²ÑÐµÐ¼ÐµÐ½Ð½Ð¾ Ñ Ð¸Ð½Ð¾ÐºÑÐ»ÑÑÐ¸ÐµÐ¹ ÐºÐ»ÐµÑÐ¾Ðº Ð°Ð´ÐµÐ½Ð¾ÐºÐ°ÑÑÐ¸Ð½Ð¾Ð¼Ñ Ð­ÑÐ»Ð¸ÑÐ°, ÑÐ¿Ð¾ÑÐ¾Ð±ÑÑÐ²Ð¾Ð²Ð°Ð»Ð¾ ÑÐ»ÑÑÑÐµÐ½Ð¸Ñ Ð²ÑÐ¶Ð¸Ð²Ð°ÐµÐ¼Ð¾ÑÑÐ¸ Ð¼ÑÑÐµÐ¹, Ð¿ÑÐµÐ´Ð¿Ð¾Ð»Ð¾Ð¶Ð¸ÑÐµÐ»ÑÐ½Ð¾ Ð·Ð° ÑÑÐµÑ ÑÐ½Ð¸Ð¶ÐµÐ½Ð¸Ñ Ð¿ÑÐ¾Ð»Ð¸ÑÐµÑÐ°ÑÐ¸Ð¸ Ð¾Ð¿ÑÑÐ¾Ð»ÐµÐ²ÑÑ ÐºÐ»ÐµÑÐ¾Ðº. Ð¢Ð°ÐºÐ¶Ðµ Ð¸Ð½ÑÐµÐºÑÐ¸Ð¸ Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸Ñ ÑÐµÑÐµÐ±ÑÐ° ÑÐ½Ð¸Ð¶Ð°Ð»Ð¸ ÑÑÐ°ÑÑÑ Ð¼ÐµÐ´Ð¸ Ð² ÑÑÐ²Ð¾ÑÐ¾ÑÐºÐµ ÐºÑÐ¾Ð²Ð¸ Ð¼ÑÑÐµÐ¹ Ñ ÑÐ°ÑÑÑÑÐµÐ¹ Ð¾Ð¿ÑÑÐ¾Ð»ÑÑ. ÐÐ± ÑÑÐ¾Ð¼ ÑÐ²Ð¸Ð´ÐµÑÐµÐ»ÑÑÑÐ²ÑÐµÑ ÑÐ½Ð¸Ð¶ÐµÐ½Ð¸Ðµ ÐºÐ¾Ð½ÑÐµÐ½ÑÑÐ°ÑÐ¸Ð¸ Ð¼ÐµÐ´Ð¸ Ð¸ ÑÐµÑÐ¼ÐµÐ½ÑÐ°ÑÐ¸Ð²Ð½Ð¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÑÐµÑÑÐ»Ð¾Ð¿Ð»Ð°Ð·Ð¼Ð¸Ð½Ð°, Ð½Ð¾ Ð½Ðµ ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸Ñ Ð±ÐµÐ»ÐºÐ°.Â  ÐÑÐ»Ð° Ð¿Ð¾Ð´Ð°Ð²Ð»ÐµÐ½Ð° ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ñ Ð³ÐµÐ½Ð¾Ð² Ð¾Ð¿ÑÑÐ¾Ð»ÐµÐ²ÑÑ ÑÐ°ÐºÑÐ¾ÑÐ¾Ð² LOXP Ð¸ TNFa Ð² ÐºÐ»ÐµÑÐºÐ°Ñ Ð¿ÐµÑÐµÐ½Ð¸ Ð¸ HIF1Î±, TNFa, LOX, ATOX1, ATP7A, DMT1 Ð¸ MT Ð² ÐºÐ»ÐµÑÐºÐ°Ñ Ð¾Ð¿ÑÑÐ¾Ð»Ð¸.
description: In recent years, a large amount of data has been accumulated indicating the active participation of copper in tumor growth and development, therefore it is important to find safe approaches to reduce the copper status in the body as an anti-tumor therapy. Presumably, this is possible by administration of silver nanoparticles, but the exact mechanism of their effect on the progression of tumors has not been established. Therefore, the purpose of this work was to study the effect of silver nanoparticles on the growth of ascitic Ehrlich carcinoma. For each study group, a different treatment protocol with nanoparticles administration was chosen, the differences between them were the time of the first injection and the duration of silver nanoparticles administration. Intraperitoneal administration of silver nanoparticles, that was initiated simultaneously with the inoculation of Ehrlichs adenocarcinoma cells, improved the survival of mice, presumably by reducing the proliferation of tumor cells. In addition, the injections of silver nanoparticles reduced the copper status in the blood serum of the mice with a growing tumor. This is proven by a decrease in the concentration of copper and the enzymatic activity of ceruloplasmin, but not the protein content. The expression of the genes of tumor factors LOXP and TNFa in liver cells and HIF1a, TNFa, LOX, ATOX1, ATP7A, DMT1 and MT in tumor cells was suppressed.