cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Analyse der Literatur zu Klimawirkungen in Deutschland: ein Gesamtbild mit Lücken
Creators: name: Fleischhauer, Mark
name: Greiving, Stefan
name: Lindner, Christian
name: Schauser, Inke
Publisher: name: My University
Year: 2017

description: Dieses Kapitel präsentiert Ergebnisse einer umfassenden Literaturauswertung zu relevanten Klimawirkungen für Deutschland, die im Rahmen des Projekts ćNetzwerk Vulnerabilität̮ vorgenommen wurde. Es zeigt auf, dass ein aggregiertes Gesamtbild der Klimawirkungen für Deutschland als Grundlage für Folgenabschätzungen und Anpassungsplanungen noch nicht gezeichnet werden kann, da eine große Bandbreite an Ansätzen zur Bewertung von Vulnerabilitäten oder Klimawandelfolgen existiert und die gegenwärtig vorhandenen Klimawirkungs- und Vulnerabilitätsstudien von großer Heterogenität gekennzeichnet sind. Als erster Schritt wird deshalb eine Zusammenschau bereits vorhandener Ansätze geliefert. Quelle: http://link.springer.com
Dismembers of the audience: the expulsive, explosive force of bodies in games
Creators: name: Wilken, Rowan
Publisher: name: Swinburne
Year: 2024

description: In this paper, a conceptual framework is developed for critiquing extreme violence in computer and videogames from an aesthetic perspective. In particular focus is the common play element of ‘corpseplay’ and the reduction of the physical form into ‘gibs’, chunks and blood. What occurs when the player turns enemies into a screaming ballet of slow-motion meat? The mechanics underlying games suggest a release of forces and tensions, so how does it become possible, if at all, to speak in general and specific terms about extreme videogame violence?
Panel discussion on „Open Science in a Time of Global Crises“
Creators: name: Tochtermann, Klaus
name: Masuzzo, Paola
name: Opialla, Tobias
name: Persic, Ana
name: Polka, Jessica
Publisher: name: Forschungzentrum Jülich
Year: 2021
Subjects: Other

description: doi:10.5446/53440
description: The Open Science Conference 2021 is the 8th international conference of the Leibniz Research Alliance Open Science. The annual conference is dedicated to the Open Science movement and provides a unique forum for researchers, librarians, practitioners, infrastructure providers, policy makers, and other important stakeholders to discuss the latest and future developments in Open Science. https://www.open-science-conference.eu/ #osc2021
Challenges of Multi-Temporal and Multi-Sensor Forest Growth Analyses in a Highly Disturbed Boreal Mixedwood Forests
Creators: name: Tompalski, Piotr
name: Rakofsky, Joseph
name: Coops, Nicholas C.
name: White, Joanne C.
name: Graham, Alexander N. V.
name: Rosychuk, Kyle
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Airborne laser scanning (ALS) and digital aerial photogrammetry (DAP) have both been demonstrated as reliable sources of information on forest stand inventory attributes. The increasing availability of both datasets provides a means for improving stand dynamics information over time; however, the cost of multi-temporal ALS can be prohibitive in some circumstances. As a result, a combination of ALS at an initial time step and subsequent updates using DAP has been proposed as a cost-effective alternative for maintaining forest inventories. In this study we used low density ALS and DAP point clouds acquired in 2007 and 2015, respectively, to quantify changes in forest structure, in a highly disturbed boreal mixedwood forest in Alberta, Canada. We examined the capacity of the two technologies to model changes in top height (H), volume (V), and basal area (BA) using both direct and indirect approaches for estimation. Results indicate that the proportion of explained variance (adjusted R²) for the models derived from the ALS (Time 1; T1) and DAP (Time 2; T2) data were highest for models predicting H at T1, and lowest for BA at T1 and T2 (R² was 0.66–0.70). The indirect estimates of change in H, BA, and V were calculated by subtracting the T1 and T2 predictions. For the direct approach, separate regression models were developed that used the differences in point cloud metrics between T1 and T2 as predictors. Results indicated that the accuracy of the estimates generated using the indirect approach were markedly lower than the estimates generated using the direct approach, with especially poor results for ∆BA and ∆V. Best results were achieved for ∆H using the direct approach with an R² coefficient of 0.65 and an root mean square error (RMSE)% of 190.06%. We found that the error associated with change estimates of H, BA and V increased with the increase or decrease in mortality. We conclude that forest managers should act carefully when applying the multi-temporal and multi-sensor analysis of forest growth if forest growth is slow and the level of mortality is high.
Transition en milieu communautaire d'enfants-adultes vivant avec une déficience intellectuelle : perceptions des parents.
Creators: name: Lafontaine, Luce.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Health Sciences, Mental Health.

description: Cette étude examine l'effet de la désinstitutionnalisation sur les perceptions de parents d'enfants-adultes vivant avec une déficience intellectuelle. L'échantillon est constitué de' 66 participants divisés en deux groupes. Le groupe expérimental comptait 33 personnes responsables d'un enfant-adulte qui allait vivre la transition d'un milieu institutionnel à un milieu communautaire. Le groupe témoin comptait aussi 33 personnes responsables d'un enfant-adulte qui vivait dans la communauté depuis au moins deux ans. Les membres du groupe expérimental ont été évalués avant la désinstitutionnalisation de l'enfant-adulte et de nouveau de quatre à six mois après la transition en milieu communautaire. Les sujets du groupe témoin ont été évalués deux fois en respectant un intervalle similaire à celui du groupe expérimental. Les instruments de mesure utilisés sont l'Inventaire des rôles liés à l'intégration sociale (version revisée), l'Échelle des comportements négatifs, l'Échelle québécoise de comportements adaptatifs (ÉQCA), l'Échelle de stress familial et l'Échelle de fréquence des contacts. Les résultats indiquent, pour les deux groupes, qu'il n'existe aucune différence entre les perceptions parentales aux deux temps d'évaluation, sauf pour la fréquence de contacts des parents du groupe expérimental avec l'enfant-adulte. Le nombre de visites des parents à l'enfant-adulte dans sa nouvelle résidence a augmenté significativement. Il ressort aussi des analyses effectuées que l'augmentation de la fréquence des contacts est associée à une réduction de la distance entre le domicile familial et le milieu de vie de l'enfant-adulte vivant avec une déficience intellectuelle. Enfin, les analyses révèlent une réduction du nombre de comportements négatifs, tels qu'évalués par les intervenants, approchant du niveau de signification.
Habitat disturbance influences the skin microbiome of a rediscovered neotropical-montane frog
Creators: name: Jiménez, Randall R.
name: Alvarado, Gilbert
name: Sandoval, José
name: Sommer, Simone
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Skin bacterial diversity
subject: 16S rRNA amplicon sequencing
subject: Land-use change
subject: Anthropogenic disturbance
subject: Amphibian health implications and conservation
subject: DDC 570 / Life sciences
subject: DDC 590 / Animals (Zoology)
subject: Batrachochytrium dendrobatidis
subject: Landnutzung

description: Background: The skin microbiome serves as a first line defense against pathogens in vertebrates. In amphibians, it has the potential to protect against the chytrid fungus Batrachochytrium dendrobatis (Bd), a likely agent of amphibian declines. Alteration of the microbiome associated with unfavorable environmental changes produced by anthropogenic activities may make the host more susceptible to pathogens. Some amphibian species that were thought to be “extinct” have been rediscovered years after population declines in the late 1980s probably due to evolved Bd-resistance and are now threatened by anthropogenic land-use changes. Understanding the effects of habitat disturbance on the host skin microbiome is relevant for understanding the health of these species, along with its susceptibility to pathogens such as Bd. Here, we investigate the influence of habitat alteration on the skin bacterial communities as well as specifically the putative Bd-inhibitory bacterial communities of the montane frog Lithobates vibicarius. This species, after years of not being observed, was rediscovered in small populations inhabiting undisturbed and disturbed landscapes, and with continuous presence of Bd. Results: We found that cutaneous bacterial communities of tadpoles and adults differed between undisturbed and disturbed habitats. The adults from disturbed habitats exhibited greater community dispersion than those from undisturbed habitats. We observed a higher richness of putative Bd-inhibitory bacterial strains in adults from disturbed habitats than in those from undisturbed habitats, as well as a greater number of these potential protective bacteria with a high relative abundance. Conclusions: Our findings support the microbial “Anna Karenina principle”, in which disturbance is hypothesized to cause greater microbial dispersion in communities, a so-called dysbiosis, which is a response of animal microbiomes to stress factors that decrease the ability of the host or its microbiome to regulate community composition. On the positive side, the high richness and relative abundance of putative Bd-inhibitory bacteria may indicate the development of a defense mechanism that enhances Bd-protection, attributed to a co-occurrence of more than 30-years of host and pathogen in these disturbed habitats. Our results provide important insight into the influence of human-modified landscapes on the skin microbiome and health implications of Bd-survivor species.
Flaxseed and its Important constituents
Creators: name: Binod Kumar Bharti, Sonia Kumari, A.K.Jha and J. Badshah
Publisher: name: Zenodo
Year: 2024

description:  

Flaxseed is considered as one of the oldest crops in the world, it is cultivated since the beginning of civilization. The Latin name of the flaxseed is known as Linum usitatissimum, means “very useful”. Flaxseed was first introduced in the United States of America for producing fiber for clothing. Every part of the flaxseed plant is utilized commercially either directly or after processing treatment. The stem of flaxseed yields high quality of fibers and having high strength and durability (Singh et al., 2011). Flax has been used for the fabrication of cloths and papers and flaxseed oil are used in animal feed formulation. The terms flaxseed oil is sometimes also known as linseed oil. Flaxseed focused in the field of diet and disease due to the potential health benefits associated with some of its biologically active components. Flaxseeds have many nutritional properties and it is also rich source of ω-3 fatty acid (α-linolenic acid), short chain polyunsaturated fatty acids, soluble and insoluble fibers, phytoestrogenic lignans, proteins and antioxidants (Ivanova et al., 2011; Alhassane and Xu 2010). flaxseed and flaxseed oil have medicinal value so it is used as a functional food. Flaxseed have many nutritional properties because it contains high in protein, fibre etc.
Land Degradation Neutrality
Creators: name: Wunder, Stephanie
name: Kaphengst, Timo
name: Frelih-Larsen, Ana
Publisher: name: My University
Year: 2018
Subjects: subject: Bodenschutz
subject: Boden
subject: Flächennutzung
subject: Bodendegradation
subject: Nachhaltigkeitsstrategie
subject: land degradation neutrality
subject: Landdegradationsneutralität
subject: Landnutzung
subject: SDGs
subject: Sustainable Development Goals
subject: UN-Nachhaltigkeitsziele
subject: Boden | Fläche

description: Vor dem Hintergrund der zunehmenden Bedrohung durch die Degradation von Land und Böden wurde in diesem Projekt untersucht, wie SDG-Unterziel 15.3, welches eine landdegradationsneutrale Welt bis zum Jahr 2030 anstrebt, erreicht werden kann. Der Bericht schlägt insbesondere eine Vorgehensweise zur Umsetzung von Land Degradation Neutrality (LDN) auf nationaler Ebene vor und untersucht, welche Indikatoren sich für die Erfassung von LDN eignen könnten. Darüber hinaus wurde ein Ansatz für einen ⁠Indikator⁠ zur Erfassung von LDN entwickelt, der basierend auf Landnutzungskategorien, unabhängig von aufwändig zu messenden Bodenparametern, Rückschlüsse auf die Bodenqualität ermöglichen soll.
Cisplatin resistance in nonsmall cell lung cancer: Role of platinum accumulation and cell membranes.
Creators: name: Popovic, Predrag.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Biology, Cell.

description: A cisplatin resistant cell line named E-8/0.7 was derived from the nonsmall cell lung cancer HTB 56 cell line. According to IC$\sb{50}$ estimations, E-8/0.7 cells were approximately 7.7 times more resistant to cisplatin than were HTB 56 cells. Uptake of cisplatin 100 $\mu$M over 1 hour was measured by atomic absorption spectrophotometry, and showed around a 30% lower uptake in E-8/0.7 cells compared to HTB 56 cells. Barotropic behaviour was analyzed by pressure tuning infrared spectroscopy. In the CH symmetric stretching region, we found a lower break point (and consequently lower membrane fluidity) in E-8/0.7 cells compared to the parent cell line. Lipid analyses of the two cell lines showed a higher cholesterol to phospholipid molar ratio in E-8/0.7 than in HTB 56 cells. Moreover, concentration of sphingomyelin was higher in E-8/0.7 cells than in HTB 56 cells.
Étude des critères d'évaluation d'un stage d'enseignement.
Creators: name: Charland, Julie Marie Lise.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Education, Tests and Measurements.

description: Cette these porte sur les criteres d'evaluation des stages d'enseignement en Ontario francais. La recension des ecrits comprend des recherches sur certains aspects de cette evaluation ainsi que des analyses de formulaires d'evaluation de stages employes par differentes universites. Il ressort de la recension des ecrits qu'il n'y a pas de consensus sur les criteres de reussite d'un stage d'enseignement. Consequemment, la presente etude pose les questions de recherche suivantes: (1) Quels sont les criteres d'evaluation consideres par le panel d'experts comme essentiels a la reussite d'un stage d'enseignement? (2) Quels sont les criteres d'evaluation consideres par le panel d'experts comme complementaires a la reussite d'un stage d'enseignement? Pour y repondre, une technique Delphi a ete employee. L'objectif etait d'obtenir un consensus parmi des experts de quatre groupes: les enseignants associes, les etudiants mai tres, les superviseurs universitaires et les administrateurs. Les deux premieres rondes ont permis aux participants de chaque groupe de suggerer des criteres et d'en juger l'importance au sein de leur groupe alors qu'au troisieme et dernier tour, les criteres suggeres par tous les groupes etaient presentes a l'ensemble des participants. Au terme de l'exercice, il y a eu un consensus sur 32 criteres juges essentiels et quatre juges complementaires. Ces criteres sont repartis sous quatre themes: la facon d'enseigner, la gestion de la classe, les responsabilites professionnelles et les relations interpersonnelles. Quatorze des criteres identifies par les experts n'avaient pas ete releves dans les recherches anterieures ni dans les formulaires consultes.
Segnare il confine con una performance ciclistica. In bicicletta sulle strade dell'identità (Trentino, 1908)
Creators: name: Tonezzer, Elena
Publisher: name: Alma Mater Studiorum, University of Bologna
Year: 2010

description: Segnare il confine con una performance ciclistica. In bicicletta sulle strade dell'identità (Trentino, 1908)
Alcoholism treatment digest (Release No. 62, December 14, 1962)
Creators: name: Keller, Mark
Publisher: name: No Publisher Supplied
Year: 1962

description: The Alcoholism Treatment Digest was a subscription-based publication prepared for special clients by the editorial department of the Quarterly Journal of Studies on Alcohol / Journal of Studies on Alcohol from 1950 to 1973 with Mark Keller as editor. It was published in February, April, June, October, and December, summarizing scholarly content on four topics, available to republish with attribution. Some of the reviews were simultaneously published in the "Connecticut Review on Alcoholism" under the identical subtitle "Alcoholism Treatment Digest" every other month. The authors of the reviews were first noted in 1964, in the June issue.Contents, Release No. 621.Psychodynamic Aspects of Drug Treatments in Alcoholism2.·The Role of the Clergy in Treating Alcoholism3.Dialysis - -A Life-Saving Procedure in ·Severe Alcohol Poisoning 4.Procrastination - -An Alcoholic Defense Against Sobriety
Rewards and Incentives for Open Science: A global registry, a global collaboration
Creators: name: Hanahoe, Hilary
Publisher: name: Forschungzentrum Jülich
Year: 2021
Subjects: Other

description: doi:10.5446/52031
description: The Open Science Conference 2021 is the 8th international conference of the Leibniz Research Alliance Open Science. The annual conference is dedicated to the Open Science movement and provides a unique forum for researchers, librarians, practitioners, infrastructure providers, policy makers, and other important stakeholders to discuss the latest and future developments in Open Science.
Nascita di un sapere razziale. La ziganologia nell'Inghilterra tardo-vittoriana tra esotismo, filantropismo e governo delle razze
Creators: name: Turrini, Mauro
Publisher: name: Alma Mater Studiorum, University of Bologna
Year: 2010

description: Nascita di un sapere  razziale. La ziganologia nell'Inghilterra tardo-vittoriana tra  esotismo, filantropismo e governo delle razze
Brand and Value Co-Creation: A Stakeholder Approach to Ottawa's CFL Expansion Franchise
Creators: name: Rodrigue, Francois
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: co-creation
value
brand equity
football
value co-creation
brand co-creation
branding
marketing

description: This study intended to advance the understanding of brand and value co-creation in sport management. A single exploratory case study of the Ottawa REDBLACKS, the CFL expansion franchise launching in 2014, was conducted. The purpose of the research was to unveil the practices that could lead to brand and value co-creation in the relationships between the Ottawa REDBLACKS and their stakeholders. Semi-structured interviews were performed with 20 participants from the focal organization’s network of stakeholders. The sample was built through a purposeful and snowball sampling method that added to stakeholders identified from the literature. Archival data of media publications, organizational online content, and radio podcasts were also gathered in order to complement the data from the interviews. The deductive and inductive data analysis highlighted five main practices that could lead to brand or value co-creation in the stakeholder-firm relationship performance in a unique sport context: establishing relationships, supporting public relations, sharing resources, enhancing the experience, and driving brand image. The findings explained that joint actions between stakeholders and the REDBLACKS can lead to increases in brand equity and value creation. In the end, the study suggested that future research should investigate the threat of co-destruction.
What are some possible and likely solutions to the current and future labour shortage in Japan?
Creators: name: Omori, Maho
Publisher: name: Swinburne
Year: 2024

description: The aim of this study was to investigate what are some possible and likely solutions in the current and future labour shortage in Japan. The three possible solutions were examined and evaluated. These were: increasing Japanese women’s workforce participation; accepting more foreign workers; developing automation. The document analyses of a range of secondary sources were conducted. Overall, these three solutions may certainly ease the labour shortage in Japan. None of them, however, are perfect solutions by themselves because the feasibility of them varies between business sectors. Moreover, socio-cultural aspects have had enormous influences on these solutions. Cultural barriers, the ideology of traditional gender roles and cultural homogeneity, are too strong for the first and second solutions respectively (i.e. Japanese women and foreign workers) to bring successful outcomes to the labour shortage. By contrast, there are more limited cultural barriers constraining the third solution (i.e. automation) from easing the labour shortage and rather, cultural aspects may facilitate it.
The noise properties of 42 millisecond pulsars from the European Pulsar Timing Array and their impact on gravitational-wave searches
Creators: name: Caballero, R. N.
name: Lee, K. J.
name: Lentati, L.
name: Desvignes, G.
name: Champion, D. J.
name: Verbiest, J. P. W.
name: Janssen, G. H.
name: Stappers, B. W.
name: Kramer, M.
name: Lazarus, P.
name: Possenti, A.
name: Tiburzi, C.
name: Perrodin, D.
name: Oslowski, S.
name: Babak, S.
name: Bassa, C. G.
name: Brem, P.
name: Burgay, M.
name: Cognard, I.
name: Gair, J. R.
name: Graikou, E.
name: Guillemot, L.
name: Hessels, J. W. T.
name: Karuppusamy, R.
name: Lassus, A.
name: Liu, K.
name: McKee, J.
name: Mingarelli, C. M. F.
name: Petiteau, A.
name: Purver, M. B.
name: Rosado, P. A.
name: Sanidas, S.
name: Sesana, A.
name: Shaifullah, G.
name: Smits, R.
name: Taylor, S. R.
name: Theureau, G.
name: van Haasteren, R.
name: Vecchio, A.
Publisher: name: Swinburne
Year: 2024

description: The sensitivity of Pulsar Timing Arrays to gravitational waves (GWs) depends on the noise present in the individual pulsar timing data. Noise may be either intrinsic or extrinsic to the pulsar. Intrinsic sources of noise will include rotational instabilities, for example. Extrinsic sources of noise include contributions from physical processes which are not sufficiently well modelled, for example, dispersion and scattering effects, analysis errors and instrumental instabilities. We present the results from a noise analysis for 42 millisecond pulsars (MSPs) observed with the European Pulsar Timing Array. For characterizing the low-frequency, stochastic and achromatic noise component, or `timing noise', we employ two methods, based on Bayesian and frequentist statistics. For 25 MSPs, we achieve statistically significant measurements of their timing noise parameters and find that the two methods give consistent results. For the remaining 17 MSPs, we place upper limits on the timing noise amplitude at the 95 per cent confidence level. We additionally place an upper limit on the contribution to the pulsar noise budget from errors in the reference terrestrial time standards (below 1 per cent), and we find evidence for a noise component which is present only in the data of one of the four used telescopes. Finally, we estimate that the timing noise of individual pulsars reduces the sensitivity of this data set to an isotropic, stochastic GW background by a factor of >9.1 and by a factor of >2.3 for continuous GWs from resolvable, inspiralling supermassive black hole binaries with circular orbits.
Ghrelin-based therapies for ALS – understanding mechanisms of action
Creators: name: Gray, James Alexander
Publisher: name: The University of St Andrews
Year: 2024
Subjects: ALS
Motor neuron disease
Ghrelin
Leptin
Metabolism
Neuroendocrinology

description: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder with no effective treatment. A difficulty in synthesising an effective treatment for ALS stems from its heterogenous nature and that there are numerous pathological processes involved in progression. Therefore, the need for a therapy which can effectively target multiple pathways, thus being effective in treating numerous forms of the disease, is imperative. Ghrelin is an endogenous growth hormone that enhances appetite. ALS patients show reduced ghrelin, whilst having a lower body mass index, suggesting impaired ghrelin signalling contributes to disease progression, with ghrelin having been found to exert neuroprotective effects on primary murine motor neurons. In chapter 2, to investigate the neuroprotective capabilities of ghrelin against the reactive oxygen species (ROS) hydrogen peroxide (H₂O₂), SH-SY5Y human neuroblastoma cells were utilised. In these experiments, treatment with ghrelin led to an increase in cell viability when cells were faced with H₂O₂ insult. Chapter 3 utilised NSC-34 murine motor neuron-like cells to assess the effects of ghrelin on The cytokine TNF-α was utilised to mimic pro-inflammatory conditions observed in ALS patients. Ghrelin provided significant protection against cell death and improvements to cell viability. Subsequent experiments found that ghrelin treatment reduced caspase 3 activation, suggesting that ghrelin prevents apoptosis via inhibition of the caspase pathway. In chapter 4, in order to further understanding of ghrelin’s ability to attenuate the immune response, BV-2 microglial cells, alone and in co-culture with NSC-34 cells were utilised. It was found that treatment with ghrelin led to a decrease in microglial CD68 expression, a proxy for lysosomal activity following LPS inducement. Pilot qPCR data (n=1) also suggests in addition to a reduction in proinflammatory cytokines, ghrelin treatment leads to an upregulation of anti-inflammatory cytokines. Therefore, future experiments should focus on understanding how ghrelin may modulate microglia from their active to tissue repair state. The pathology of ALS and effects of ghrelin both involve a wide range of molecular pathways the data presented in this study highlight areas of interest for subsequent experiments involving shared aspects of ALS pathology and ghrelin, namely anti-inflammatory, mitochondrial and metabolic function.
An Analysis of Genome-Wide Association Studies to Produce Evidence Useful in Guiding Their Reporting and Synthesis
Creators: name: Yurkiewich, Alexander John
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: Genome-Wide Association Studies

description: Introduction The present study evaluated reported methodological characteristics of GWAS, investigating relationships between reported methodological characteristics and outcomes observed. Methods GWAS were identified from NHGRI’s catalogue of GWAS (2005 to 2009). Multivariate meta-regression models (random effects) were produced to identify the impact of reported study characteristics and the strength of relationships between the variables and outcomes. Results The summary odds ratios for replication components of GWAS in cancer was 1.34 (95% CI 1.25, 1.43) and neuropsychiatric disorders was 1.43 (95% CI 1.30, 1.57). Heterogeneity was accounted for by nature of the control group, relationship between case/control groups, whether cases/controls were drawn from the same population, if data was a primary collection or a build on pre-existing data, if quality assurance was reported, and if the study reported power/sample size. Conclusion Evidence supports the existence of variability in reporting, with index components demonstrating less variability than replication components in the GWAS.
How annulus defects can act as initiation sites for herniation
Creators: name: Wade, K.
name: Berger-Roscher, N.
name: Saggese, T.
name: Rasche, V
name: Wilke, Hans-Joachim
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Disc herniation
subject: Complex loading
subject: Disc prolapse
subject: DDC 610 / Medicine & health
subject: Microstructure
subject: Intervertebral Disc Displacement
subject: Annulus Fibrosus
subject: Mikrostruktur

description: Purpose Both posture and loading rate are key factors in the herniation process and can determine the mechanism of disc failure. The aim of this study was to test the hypothesis that disruption visible with HR-MRI post-testing corresponds with microstructural features and further elucidate the mechanism by which this disruption weakens the disc. This will enable us to gain new insights into the herniation process. Methods Thirty ovine lumbar spinal segments were subjected to combinations of four loading conditions (0–12° flexion, 0–9° lateral bending, 0–4° axial rotation, 0–1500 N axial compression) for 1000 loading cycles at 2 Hz in a dynamic disc loading simulator. The discs were scanned in an ultra-high field MRI (11.7 T) then examined using brightfield microscopy to examine their microstructure. Results Four discs herniated and seven discs suffered nucleus displacement. These discs contained pre-existing defects in the central posterior annulus. Generally, following testing discs contained more posterior annulus disruption, Microstructural investigation revealed there was clear correspondence between HR-MRI and microstructural observations, and that the mid-outer annular-endplate junction had failed in all discs examined in this study. Conclusions While all discs suffered outer annulus damage, only the discs containing pre-existing defects herniated. These pre-existing defects weakened the inner and mid annulus, allowing herniation to occur once the mid and outer annular wall was compromised. We propose this can occur during the degenerative cascade.
Let's Make a Deal: Consumers, Negotiation and Telecommunications Pricing in Canada
Creators: name: Lauer, David
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: Canada
Consumers
Focus Groups
Negotiation
Phase Model
Pricing Strategy
Qualitative Data
Telecommunications

description: The aim of this study is to re-contextualize prior negotiation theory emanating from the field of communications in a unique contemporary setting. The research focuses on the Canadian residential telecommunications sector, where the dominant business model involves the use of a rather peculiar variable pricing strategy, which has compelled a proportion of consumers to adopt competitive negotiation strategies. Through a series of three focus groups, the project gleans insight into the participants’ experiences and perceptions of the telecommunications procurement process. Based on prior theoretical assumptions and on this original research, the study tests the appropriateness of descriptive phase models of negotiation in the Canadian telecommunications industry, providing a new dimension to the nascent body of academic research in this area.
Open Science Festival Session 5: A Student Open Science Community
Creators: name: Volz, Leonhard
name: Smal, Iris
name: Borgo, Alessia Delia
Publisher: name: Forschungzentrum Jülich
Year: 2022
Subjects: Open Science
Student Research
Community Building
Education

description: Lecture at Seminar (), ; doi:10.5281/ZENODO.7058008
description: In this session, we wanted to brainstorm on how we can improve the awareness and promotion of open science to students in the long run with educators, students, program coordinators, and any other interested parties. Additionally, pinpointing aspects of open science that are universally important to students across disciplines and discussing how open science differs between disciplines, could be very insightful when deciding how best to bring students and open science together.
Vascular access site complications do not correlate with large sheath diameter in TAVI procedures with new generation devices
Creators: name: Gonska, Birgid
name: Reuter, Christopher
name: Mörike, Johannes
name: Rottbauer, Wolfgang
name: Buckert, Dominik
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Vascular complications
subject: Bleeding
subject: Sheath size
subject: Calcification
subject: DDC 610 / Medicine & health
subject: Transcatheter aortic valve replacement
subject: Aortenklappenersatz

description: Background: Vascular complications after transfemoral transcatheter aortic valve implantation (TAVI) are associated with morbidity and mortality. However, consistent predictors have not been identified yet. The size of the implantation sheath seems to play a role, though especially with new generation TAVI devices and their improved sheaths and delivery systems this remains uncertain. Objectives: This study aimed to determine the incidence and predictors of access site-related vascular complications (VC) in the era of new generation TAVI devices. Methods and Results: Four hundred consecutive patients receiving TAVI in an experienced tertiary care center were analyzed. VC occurred in 89 patients (22.25%) with the majority being minor VC (21%) and only 1.25% major VC. Possible predictors for VC were tested, and only peri-interventional dual antiplatelet therapy (DAPT) showed to be predictive for VC [OR 2.11 (95% CI 1.10–4.06, p = 0.025)]. The female gender [OR 0.75 (95% CI 0.44–1.3), p = 0.31], sheath to femoral artery ratio >1.05 [OR 1.18 (95% CI 0.66–2.08, p = 0.58)], calcification of the access site vessel [OR 0.83 (95% CI 0.48–1.42, p = 0.48)], known peripheral artery disease [OR 0.95 (95% CI 0.4–2.25, p = 0.9)], and BMI 25 kg/m² [OR 0.69 (95% CI 0.41–1.19, p = 0–19)] were not predictive of VC. The larger sheath with 20 French even showed less VC than the smaller sheath with 16 French [OR 0.43 (95% CI 0.25–0.74, p = 0.002)]. Conclusions: Overall, the rate of major and minor VC was low in this study population (for major VC: rate of 1.25%). Predefined risk factors were not associated with the occurrence of VC, except for peri-interventional treatment with DAPT. Especially, larger sheath size could not be identified as a predictor for VC in the setting of TAVI procedures performed with contemporary devices.
Phenotypic Plasticity and Population-level Variation in Thermal Physiology of the Bumblebee 'Bombus impatiens'
Creators: name: Rivière, Bénédicte Aurélie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: bumblebee
Bombus
metabolic rate
wingbeat frequency
thermoregulation
phenotypic plasticity
thermal acclimation
latitudinal compensation
Bombus impatiens

description: Temperature variation affects most biological parameters from the molecular level to community structure and dynamics. Current studies on thermal biology assess how populations vary in response to environmental temperature, which can help determine how populations differentially respond to climate change. To date, temperature fluctuation effects on endothermic poikilotherms such as the common eastern bumblebee (Bombus impatiens) are unknown even though bumblebees are the most important natural pollinators in North America. A cold-acclimation experiment with B. impatiens colonies revealed individuals acclimated to 5°C or 10°C at night did not differ in resting metabolic rate, flight metabolic rate, wingbeat frequency, or morphological measurements, compared to the control group. Moreover, an infrared camera showed that all colonies maintained maximum nest temperature consistently above 36.8°C. A latitudinal sampling of flight metabolic rate and morphological measurements of B. impatiens from four locations spanning Ontario (N 45°; W 75°) to North Carolina (N 34°; W 77°) indicated no latitudinal trend in the measured variables. This study shows that bumblebees are well equipped to face a wide range of environmental temperatures, both in the short term and long term, and can use a combination of behavioural and physiological mechanisms to regulate body and nest temperatures. These results are reassuring on the direct effects of climate change on bumblebee ecology, but further studies on the indirect effect of temperature variation on North American bumblebees are required to predict future ecosystem dynamics.
La réflexion sur la condamnation d'innocents : l'affaire Guy Paul Morin.
Creators: name: Asubeti, Sefu Pene.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: History, Canadian.

description: Ce travail constitue, pour l'essentiel, une recherche empirique qualitative sur le problème de la condamnation d'innocents. Il se penche sur un cas exemplaire--celui de Guy Paul Morin--de ce que l'on a convenu d'appeller une "erreur judiciaire". Il s'agit de mettre en évidence le fait, qu'à partir d'un élément du caractère ou du passé d'un individu, les professionnels de l'administration de la justice prétendent parvenir à identifier un individu innocent, hors de tout doute raisonnable, comme coupable d'un délit donné. Et ce, par la pratique des manoeuvres frauduleuses et illégales telles la fabrication de preuves, la manipulation des témoins, le mensonge, l'implantation de preuves.... Il est donc ici question de reconstituer les processus qui sont à la base de la condamnation, sur des fausses preuves de Guy Paul Morin. Le présent travail est composé de quatre chapitres. Le premier situe la problèmatique théorique, le deuxième traitera de l'approche méthodologique alors que les deux derniers chapitres traiteront de la présentation et de l'analyse des données, à l'aide de la problèmatique théorique élaborée au premier chapitre. (Abstract shortened by UMI.)
Open Science in Practice
Creators: name: Papadopoulou, Elli
Publisher: name: Forschungzentrum Jülich
Year: 2020
Subjects: data management
open access
data management plan
tool
open access publishing
FAIR principles
research data management lifecycle
hands-on

description: Lecture at Seminar (), ; doi:10.5281/ZENODO.4320969
description: This lesson is part of the  Course on Open Science and Research Data Management  organised in the framework of CHIST-ERA December 11th, 2020, Module 4 Given  the engagement of CHIST-ERA in Open Science , a new Open Science policy will come into effect starting from the next CHIST-ERA Call, with new tools, standards and support. In collaboration with  OpenAIRE , the training course has been tailored to the new CHIST-ERA policy as well as to the needs of CHIST-ERA project participants. It consists of the following 4 modules: Module 1 (2 nd  December): Introduction and motivations Module 2 (4 th  December): Open Access to Publications, Open Data and FAIR Data, Open Software and FAIR software Module 3 (9 th  December): Research Data Management and Data Management Plan Module 4 (11 th  December): Hands-on session with the provided tools The course covers all modern aspects of Open Science (Publications, Open Data, FAIR principles, DMP, etc.) and familiarise you with the tools and standards now required by the new calls of CHIST-ERA.
Different and diverse anaerobic microbiota were seen in women living with HIV with unsuppressed HIV viral load and in women with recurrent bacterial vaginosis : a cohort study
Creators: name: Elwood, Chelsea
name: Albert, Arianne
name: McClymont, Elisabeth
name: Wagner, Emily
name: Mahal, Daljeet Singh
name: Devakandan, Keshini
name: Quiqley, Bonnie L.
name: Pakzad, Zahra
name: Yudin, Mark H.
name: Money, Deborah M.
name: Vogue Research Group
Publisher: name: The University of British Columbia
Year: 2020

description: Objective: To compare the vaginal microbiota of women living with HIV (WLWH) to the vaginal microbiota of women with recurrent bacterial vaginosis (BV) and healthy women without HIV to determine if there are differences in the vaginal microbiome, what factors influence these differences, and to characterize HIV clinical parameters including viral load and CD4 count in relation to the vaginal microbiome.
CRI Open Science Course
Creators: name: Hidalgo, Enric Senabre
name: Tzovaras, Bastian Greshake
name: Atal, Ignacio
name: Lindner, Ariel
Publisher: name: Forschungzentrum Jülich
Year: 2021
Subjects: open science
research design

description: Lecture at Seminar (), ; doi:10.5281/ZENODO.4767242
description: This is a printed version of the open educational resource 'CRI Open Science Course', originally published on Wikiversity (editable version) .
Design of an agile manufacturing workcell for light mechanical applications
Creators: name: Quinn, Roger D.
name: Causey, Greg C.
name: Merat, Frank L.
name: Sargent, David M.
name: Barendt, Nicholas A.
name: Newman, Wyatt S.
name: Velasco Jr., Virgilio B.
name: Podgurski, Andy
name: Jo, Ju-yeon
name: Sterling, Leon S.
name: Kim, Yoohwan
Publisher: name: Swinburne
Year: 2024

description: This paper introduces a design for agile manufacturing workcells intended for light mechanical assembly of products made from similar components (i.e. parts families). We define agile manufacturing as the ability to accomplish rapid changeover from the assembly of one product to the assembly of another product. Rapid hardware changeover is made possible through the use of robots, flexible part feeders, modular grippers and modular assembly hardware. The flexible feeders rely on belt feeding and binary computer vision for pose estimation. This has a distinct advantage over nonflexible feeding schemes such as bowl feeders which require considerable adjustment to changeover from one part to another. Rapid software changeover is being facilitated by the use of a real-time, object-oriented software environment, modular software, graphical simulations for off-line software development, and an innovative dual VMEbus controller architecture. These agile features permit new products to be introduced with minimal downtime and system reconfiguration.
W. V. Quine and Ludwig Wittgenstein: Two approaches to philosophy.
Creators: name: Sigouin, Tara-Lynne.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Philosophy.

description: This dissertation explores the works of W. V. Quine and Ludwig Wittgenstein. It provides a detailed and comprehensive discussion of their distinct conceptions of philosophy. It shows how Quine is involved in a scientific philosophy aimed at the discovery of truth and explanation. It also demonstrates how Wittgenstein's critical approach attempts to dissolve philosophical problems and theories. The main purpose of this work is to explain how a proper understanding of each philosopher's framework of study, is crucial to the understanding and criticism of their respective philosophical ideas. The only way to properly refute Quine's theories is to evaluate them in a scientific framework. Any other interpretation could change his intention and weaken his arguments. Similarly, the only way to refute Wittgenstein's claims is to interpret them in everyday language. However, this is not to say that either view can be refuted. It is simply to point out that any attempt to oppose Wittgenstein's claims from a scientific viewpoint, or Quine's from a non-scientific perspective, will be flawed since it is contrary to the way in which each view was conceived.
Supplementary document for Photonic polymeric structures and electrodynamics simulation method based on a coupled oscillator finite-difference time-domain (O-FDTD) approach - 5093362.pdf
Creators: name: Adão, Ricardo
name: Caño-García, Manuel
name: Maibohm, Christian
name: Nieder, Jana
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Simulation and Modelling

description: Supplemental Document
title: Development of spray dried solid dispersion formulations to improve oral and pulmonary delivery
Creators: name: Hibbard, Thomas
Publisher: name: University of Reading
Year: 2023

description: Chapter 1 presents an introduction for crystal engineering in formulation development 
with emphasis on salt, co-crystal, and solid dispersion formation. Preparation, 
characterisation, and applications for oral and inhaled delivery are outlined, with a focus 
on preparation using spray drying. 
Chapter 2 reviews literature on solid dispersion formulations for carrier free, dry powder 
inhalation, outlining applications for antimicrobial and anticancer therapies. 
Chapter 3 reports four new ciprofloxacin salts with dicarboxylic acids and their X-ray, 
thermal, and spectroscopic characterisation. All salts showed enhanced saturated 
solubility, especially the glutaric acid salt which was higher than ciprofloxacin 
hydrochloride monohydrate. 
Chapter 4 describes the formulation of ciprofloxacin salt solid dispersions with HPMC, 
through contrasting three-fluid nozzle spray drying methods. The formulations showed 
modified ciprofloxacin release and enhanced powder aerosolisation properties. Solution 
and suspension spray drying methods generated solid dispersions with differing in vitro 
and in vivo drug release.
Chapter 5 presents the preparation of spray dried progesterone formulations for dry 
powder inhalation. Form II progesterone polymorph was present in the crystalline state, 
independent of feedstock solvent or excipients. Formulations with HPMCAS showed no 
temperature induced phase change to Form I as well as increased kinetic solubility and 
fine particle fraction. 
Chapter 6 describes a new progesterone co-crystal following in silico and experimental 
screening, followed by provisional scale up method testing. The co-crystal showed 
enhanced dissolution compared to progesterone and then UtrogestranTM when 
formulated as a tablet. 
Chapter 7 explores how spray drying process parameters influence the preparation of 
salicylic acid:caffeine co-crystal. All two-fluid and three-fluid nozzle methods generated 
co-crytsal although to differing crystallinities and with additional crystalline caffeine 
phase dependent on feedstock composition. 
Chapter 8 summarises key findings with their critical evaluation and suggestions for 
future work. Spray drying can prepare salts, co-crystals, and solid dispersions for use in 
inhaled and oral formulation development.
Www.CompanyNameSucks.com: Effetti orizzontali dei diritti fondamentali sulle parti private nella legge autonoma di Internet
Creators: name: Karavas, Vaios
name: Teubner, Gunther
Publisher: name: Alma Mater Studiorum, University of Bologna
Year: 2010

description: Www.CompanyNameSucks.com: Effetti orizzontali dei diritti fondamentali sulle parti private nella legge autonoma di Internet
Tutorial Open Science - SEBD2020
Creators: name: Lazzeri, Emma
name: Manghi, Paolo
Publisher: name: Forschungzentrum Jülich
Year: 2020
Subjects: Open Science
Open Access
Reproducibility
FAIR data
European Commission OS mandates

description: Lecture at Seminar (), ; doi:10.5281/ZENODO.3904168
description: Tutorial Speakers: Paolo Manghi , CNR-ISTI, CTO of the European OpenAIRE e-infrastructure Emma Lazzeri , CNR-ISTI, OpenAIRE National Open Access Desk Tutorial contents: How does science work today? Scientific process and scientific communication Scientific indicators Market interests and business models in the current research evaluation system Open Science Open Science: science set free Open Access: advantages, cultural barriers, European mandates and obligations Open Data: why and how to manage research data FAIRness of research products Reproducibility of science and state of the art in Computer Science
Open Science, FAIR data
Creators: name: Giglia, Elena
Publisher: name: Forschungzentrum Jülich
Year: 2020
Subjects: Open Science, Open Access, FAIR data, Data Management Plans

description: Lecture at Seminar (), ; doi:10.5281/ZENODO.3611067
description: Seminar held at IRCCS Candiolo May 2019 Topics: crisis of the current scholarly communication system, the Open alternative, European policies and framework, Open Access in practice, FAIR and Open data, Data Management Plans