cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Impact of granulocyte contamination on PBMC integrity of shipped blood samples: Implications for multi-center studies monitoring regulatory T cells
Creators: name: Agashe, Charuta
name: Berin, M. Cecilia
name: Sampson, Hugh A.
name: Chiang, David
name: Leung, Donald Y.M.
name: Wood, Robert A.
name: Jones, Stacie M.
name: Masilamani, Madhan
name: Grishin, Alexander
name: Burks, A. Wesley
name: Dawson, Peter
name: Sicherer, Scott H.
Publisher: name: Elsevier
Year: 2017

description:
In centralized immune monitoring for a multi-center allergen immunotherapy trial, we observed frequent loss of CD4+ T cell integrity following staining of cultured PBMCs with our regulatory T cell flow cytometry panel. Samples were marked by a loss of total cellular events, altered scatter properties, and reduced CD3+CD4+ events. This occurred only in samples that were stained with Foxp3 and were therefore treated with Foxp3 fixation-permeabilization buffer. We identified granulocyte contamination in samples associated with a loss of integrity, and went on to test the impact of granulocyte depletion on day-old blood samples. Granulocyte depletion prevented loss of cell integrity and CD3+CD4+ events, and reduced variability in detection of Foxp3+ cells. Addition of purified neutrophils back to PBMCs altered scatter properties and detection of CD4+ T cells. Implementation of a granulocyte depletion step in our standard operating protocols has reduced assay failure due to loss of sample integrity from 31% to 0%. Routine incorporation of a granulocyte depletion step during PBMC isolation is recommended prior to downstream immune monitoring in blood with next-day processing.
Lactate efflux inhibitors plus immunotherapy for the treatment of lung cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Checkpoint inhibitors like the blockbuster drug Keytruda have dramatically transformed the state of care for lung cancer. However, their clinical impact is limited by the fact that the tumor microenvironment in some patients is too immunosuppressed to respond to immunotherapies like Keytruda. Further, many of the other targeted therapies in lung cancer have been shown to be toxic in combination with Keytruda. One avenue under intense investigation is to identify targeted therapies that can be safely used in combination with immunotherapy. We recently identified monocarboxylate transporter 1 (MCT1) as a very promising target that may fit these requirements. We hypothesize that a significant subset of lung cancers with no other known drivers are uniquely dependent on MCT1, and that inhibitors targeting MCT1 represent a novel treatment option for these patients both as monotherapy and in combination with checkpoint inhibitors. We have generated pilot data demonstrating that several lung cancer cell models have a unique dependency on MCT1 and further show exquisite sensitivity to drugs targeting MCT1. Beyond this direct anti-tumor effect, MCT1 inhibitors may be of further therapeutic benefit to lung cancer patients due to its role in regulating immune cells. Blocking MCT1 has been recently shown to increase immune infiltration of tumors and improve response to immunotherapy.. Here, we propose to broaden our proof-of-concept work to further explore MCT1’s role in lung cancer biology, ability to potentiate immune checkpoint therapy, and predictive response biomarkers for patient selection. Ultimately, this work has the potential to enable an exciting new therapeutic option for thousands of patients with lung cancer every year.
Adolescents’ perceptions of research-based goal setting in the writing process
Creators: name: Levandowski, Douglas Oliver
Publisher: name: No Publisher Supplied
Year: 2014

description: This qualitative case study examined participants’ perceptions of research-based goal setting in the writing process.  Specifically, the five participants learned how to generate and then used implementation intentions to set goals and state how they would reach those goals in a simulated classroom setting.  In addition, this study examined how participants’ motivational structures corresponded with their opinions and uses of these goal-setting strategies.  Participants indicated that, for the most part, they felt that research-based goal setting, as it was implemented in this study, was helpful in improving their writing – though the effect of this strategy decreased when they felt rushed. In terms of the specific structure of the implementation intentions, one participant was resistant to use the strategy and one participant felt that having to state implementation intentions were excessive; she felt that simply setting a goal was adequate.  These two differences of opinion from the other three participants corresponded to different general motivation orientations.  These motivation orientations, thus, tended to correspond with differing use, both in application and in form, of goal setting and implementation intentions.  However, this study also found that participants’ motivation orientations were, in general, too complex to be placed in a single cell of the 3×2 motivation orientation matrix.  In addition, this study found that all participants tended to set goals based directly on teacher feedback.  It demonstrated that goal setting, when conducted in the context created by the SAT writing course and in accord with what researchers have identified as best practices, is perceived by adolescents as being helpful and worthwhile.  The study concludes by addressing the implications for educational practice and the avenues for potential future research.
Rhinolekos garavelloi Martins & Langeani 2011
Creators: name: Langeani, Francisco
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Siluriformes
Loricariidae
Rhinolekos
Rhinolekos garavelloi

description: Rhinolekos garavelloi Martins & Langeani (2011).
Holotype: DZSJRP 10479, 31.4 mm SL, stream at Fazenda Lageado, next to GO-213 highway, after rio Corumbá bridge, rio Paranaíba basin, Caldas Novas, Goiás, 17°44’20”S, 48°28’27”W, cols. F. Langeani, L.G.G. Silveira, D. Simiele, M.M.F. Marinho & J.P. Serra, 8 Jun 2007 (Fig. 17).
Paratypes: 2 lots, 59 specimens; DZSJRP 10477, 22 (3 c&s), 15.2–36.2 mm SL, same locality as holotype, cols. L.G.G. Silveira & F. Langeani, 11 May 2007; and DZSJRP 12191, 37 (4 c&s), 10.7–32.8 mm SL, collected with the holotype.
description: Published as part of Langeani, Francisco, 2017, Annotated catalog of the type specimens deposited at the fish collection of the " Universidade Estadual Paulista, Câmpus de São José do Rio Preto ", São Paulo, Brazil (DZSJRP), pp. 435-460 in Zootaxa 4319 (3) on page 456, DOI: 10.11646/zootaxa.4319.3.2, http://zenodo.org/record/890303
STAR (Stand against Tobacco through Advocacy and Research) in the Inland Empire (IE)
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Stand against Tobacco through Advocacy and Research (STAR) in the Inland Empire (IE) is organized around the theme of combating secondhand and thirdhand (residual nicotine & other chemicals on surfaces from tobacco) smoke exposure, through cutting edge research and advocacy, and train the next generation of tobacco control experts. Scholars will be recruited from tobacco priority populations: sexual and gender minorities, racial/ethnic minorities, low socioeconomic status, veterans, and formerly incarcerated adults. California State University San Bernardino (CSUSB) is poised due to its high prevalence student population representing such groups and student centers for recruitment (Veterans Success Center, Project Rebound for formerly incarcerated students, Queer & Transgender Resource Center, etc.). Institutional resources, such as, over 1,700 current students in health-related majors, Office of Student Research and its routine student training workshops on research and career development, as well as Center for Health Equity with its established internship programs, together able the needed foundations for student recruitment and training. CSUSB also has existing partnerships with organizations involved in tobacco-control (California Health Collaborative-San Bernardino County Tobacco Control Program, American Cancer Society-Cancer Action Network, etc.), and a track record of training students in mentored internships through such organizations. The PI, representative of tobacco priority population, has over 9 years of experience of college-level instruction, leadership roles in student recruitment and training, program development, successfully establishing two mentored research and internship programs, and has partnered with local doctoral-granting institutions on successful research outcomes; thus demonstrating the capacity and commitment for formalizing partnerships and leading the future SVFSI-Program Award. The team has together mentored over 124 students, collaboratively worked on health disparities research (including tobacco), thus demonstrating the ability to effectively recruit and support the future SVFSI award. The planning grant will thus provide time and resources needed to formalize partnerships to establish mentored advocacy projects and recruit mentors to engage scholars in cutting edge research with local doctoral granting universities.
Brassica Linnaeus 1753
Creators: name: Başköse, İsa
name: Özüdoğru, Bariş
name: Savran, Ahmet
name: Keskin, Ali
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Brassicales
Brassicaceae
Brassica

description: An Identification key of Turkish wild Brassica species;
1. Plant biennial or perennial................................................................................................................................................................. 2 +. Plant annual ....................................................................................................................................................................................... 5
2. Stem leaves amplexicaul ...................................................................................................................................................... 1. cretica +. Stem leaves not amplexicaul ............................................................................................................................................................. 3
3. Stem divaricately branched: infrutescence corymbose .............................................................................................. 3. beytepeensis + Stem not divaricately branched: infrutescence racemose or panicle................................................................................................. 4
4. Stem leaves many, leaf blade oblong, oblong-ovate, or lanceolate.................................................................................. 2. elongata +. Stem leaves few, leaf blade linear or narrow oblong............................................................................................. 8. huseyin-duralii
5. Siliquae deflexed; beak not tapering ................................................................................................................................... 4. deflexa +. Siliquae erect, erecto-patent, or spreading beak tapering.................................................................................................................. 6
6. Siliquae 10–17 mm, tightly adpressed to stem....................................................................................................................... 5. nigra +. Siliquae 30–80 mm; erect, erecto-patent, or spreading ..................................................................................................................... 7
7. Beak 10–20 mm; seeds 1.2–1.6 mm ............................................................................................................................. 6. tournefortii +. Beak 5–10 mm; seeds c. 1 mm ............................................................................................................................................. 7. juncea
description: Published as part of Başköse, İsa, Özüdoğru, Bariş, Savran, Ahmet & Keskin, Ali, 2023, A new species of Brassica (Brassicaceae) from Bolkar Mountains (Türkiye) with morphological and molecular evidence, pp. 101-117 in Phytotaxa 632 (2) on page 114, DOI: 10.11646/phytotaxa.632.2.1, http://zenodo.org/record/10438552
Inventaire du fonds Bastaire de littérature populaire et infantine [version 1]. Petits éditeurs (livres scolaires ) avant 1914
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024

description: Numérisation ICB CollEx-Persée AAP20212022
description: Les titres sont ceux donnés par Jean Bastaire. Les dates indiquées ont été établies depuis un courrier de Jean à Michel Bastaire qui lui demandait de dresser l'inventaire. Et la date de fin correspond à la donation et à la publication de Lectures englouties. Listes manuscrites de la collection établie par Jean Bastaire et Michel Bastaire ; Jean sous forme de livrets thématiques et feuilles volantes au format A5. Michel a consigné les titres dans un carnet bloc type Rhodia format A6.
description: Source: Fonds Bastaire Université Clermont Auvergne (Bas-G08_D003)
description: Relation: http://www.calames.abes.fr/pub/ms/_631139801_Bas-G08_D003
description: created: 1993/2008
A systematic review of migrant gender pay gaps: implications for Australian organizations and human resources management practices
Creators: name: Jiang, Xiaohui
Publisher: name: Macquarie University
Year: 2025
Subjects: classificationCode: 350706
subject: International business

description: Gender equality and global migration have attracted ample attention amongst the leaders of various countries and organisations around the globe. Immigrants form a critical part of Australian society as 30% of Australia's population were born outside of Australia (ABS, 2024). After decades of initiatives and efforts from the Australian Government and organisations, including improving legislation, the Workplace Gender Equality Agency (WGEA, 2024) reported a 21.7% gender pay gap in November 2023 based on Australia’s average total remuneration, which includes all payments received and annualised full time equivalent salaries of part time and casual staff from eligible organisations. However, less data is available on migrant pay gaps as the data reported is generic in nature without further categorization of immigrant status. In addition, the articles published in top tier journals mostly feature gender pay gap or migrants’ labour market experience, rarely combining the two. The lack of statistics and research created the necessity for a systematic review to understand the current state of migrant gender pay gap issue in Australia. This thesis aims to identify gaps between Australia and other countries on migrant gender pay gaps and explore the barriers to gender equality and provide insights to organisations and Human Resources Management practice by conducting an analysis on relevant legislations through a “Systematic Literature Review” of existing studies on this focal area. This thesis identified gaps in Australian legislation and studies compared to the rest of the regions, and systematic barriers experienced by female migrants, including gaps in legislation, the “double negative” effect of being a woman and a migrant, employment challenges migrants experienced due to various reasons such as location and background, discrimination, and perception from existing workforce of being a threat. This thesis also found a growing body of research exploring the effect of COVID, which disproportionately affected female migrants because they are most vulnerable to loss of employment and income. In conclusion, the implications of the research findings are discussed to provide insights to organisations and Human Resources Management practices, including reviewing and improving various policies and practices to reduce migrant gender pay gaps.
title: Petits riens sophocléens : Antigone V (v. 1095–1099, 1110–1112, 1113–1114, 1127–1130, 1140–1141 et 1149–1150, 1165–1171, 1206–1211, 1215–1218, 1223–1225, 1226–1230, 1251–1252, 1278–1280, 1344–1346)
Creators: name: Liberman, Gauthier
Publisher: name: Hyperboreus 30: 2 (2024) 173–198
Year: 2024

description: This is the last of fi ve sets of text-critical, exegetical and sometimes metrical remarks on Antigone. These *Sophocleuncula are not only minute philological notes but they involve broader issues having a bearing on the interpretation and meaning of the drama as a whole. These remarks were composed with a view to drawing attention to a number of forgotten or unseen diffi culties and to trying to address a number of seen but unsolved problems more effi caciously. The text and meaning of not a few other passages from other works of Sophocles or of other writers are also dealt with.
description: Статья представляет собой последнюю из пяти последовательных публикаций, содержащих замечания о критике текста, экзегетических и метрических сложностях в Антигоне Софокла. *Sophocleuncula посвящены не только частным филологическим проблемам, но и более общим вопросам, значимым для интерпретации драмы в целом. Заметки призваны привлечь внимание к ряду забытых или упущенных из виду сложностей и предложить более действенные решения осознаваемых, но нерешенных проблем. К анализу привлекается также немало пассажей из других произведений Софокла и других авторов.
Report of the Special Committee on Water Supply to the Senate and General Assembly
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1941

description: The Special Committee on Water Supply was created by a Concurrent Resolution of the Senate and House of Assembly and charged with the responsibility of "formulating a plan for the solution of the Water Supply Problem of the State." The committee submits herewith a series of bills intended to accomplish the desired end.The bills submitted are an expansion of the water policy and general water supply acts that have proved adequate in their sphere. the broadening of our water supply laws by new and original provisions which have been incorporated in the bills, thereby making it possible, through a central agency of the State, to finance, consolidate, construct and interconnect water supplies.
Rhinolekos schaeferi Martins & Langeani 2011
Creators: name: Langeani, Francisco
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Siluriformes
Loricariidae
Rhinolekos
Rhinolekos schaeferi

description: Rhinolekos schaeferi Martins & Langeani (2011).
Paratypes: 1 lot, 3 specimens; DZSJRP 12192 (1 c&s), 36.5–38.4 mm SL, córrego Fazenda, at Chácara Fernanda, rio Paranaíba drainage, upper rio Paraná basin, Alexânia, Goiás, Brazil, 16°7’S, 48°31’W, col. R.E. Reis, 31 December 2000.
description: Published as part of Langeani, Francisco, 2017, Annotated catalog of the type specimens deposited at the fish collection of the " Universidade Estadual Paulista, Câmpus de São José do Rio Preto ", São Paulo, Brazil (DZSJRP), pp. 435-460 in Zootaxa 4319 (3) on page 456, DOI: 10.11646/zootaxa.4319.3.2, http://zenodo.org/record/890303
Melieria Robineau-Desvoidy 1830
Creators: name: El-Hawagry, Magdi S.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Ulidiidae
Melieria

description: Genus MELIERIA Robineau-Desvoidy
Melieria Robineau-Desvoidy, 1830: 715. Type species: Melieria gangraenosa Robineau-Desvoidy, 1830 (= Musca crassipennis Fabricius, 1794), by subsequent designation (Rondani 1869).
description: Published as part of El-Hawagry, Magdi S., 2017, Catalogue of Egyptian Tephritoidea (Diptera: Schizophora: Acalyptratae), pp. 151-190 in Zootaxa 4299 (2) on page 179, DOI: 10.11646/zootaxa.4299.2.1, http://zenodo.org/record/843233
Effect of endotoxin and alum adjuvant vaccine on peanut allergy
Creators: name: McRitchie, Susan
name: Kulis, Michael
name: Johnson-Weaver, Brandi T.
name: Germolec, Dori
name: Sumner, Susan J.
name: Chan, Cliburn
name: Staats, Herman F.
name: Burks, A. Wesley
name: Mercier, Kelly A.
name: Pathmasiri, Wimal
Publisher: name: Elsevier
Year: 2017

description:
Environmental influences play a significant role in host immune responses and it is hypothesized that environmental changes may be responsible for enhanced allergy prevalence. The hygiene hypothesis proposed that smaller families and increased cleanliness reduces  infectious diseases (and thereby endotoxin exposure) in a household and contributes to enhanced allergic disease.
Assessing barriers to community engagement in applying tobacco control lessons to cannabis policy
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Legalization of cannabis has spread rapidly nationwide. Yet key public health and equity concerns are only just beginning to be addressed. Our TRDRP supported pilot research assessed incorporation of lessons from tobacco control into cannabis policy by California’s 539 cities and counties 1-2 years after adult-use was legalized. Major deficiencies were noted in adoption of policies reflecting decades of lessons from tobacco control, and specifically policies immediately relevant to the interface of tobacco, cannabis, and vaping. These include regulation of smoke-free air, vaping products, flavored products, taxation, etc. Using the research, we created and disseminated 2 years of local cannabis policy scorecards (CLCPS - see gettingitrightfromthestart.org), inspired by the American Lung Association’s widely used local tobacco control scorecards. As we worked separately to provide technical assistance to over 100 California jurisdictions, the clear challenge of paucity of engagement of community stakeholders with experience from tobacco control, substance abuse prevention, youth advocacy, and others in the cannabis policy process grew evident. Decision-making appears dominated by cannabis industry engagement with public officials. The proposed study will examine factors that make it harder or easier to engage stakeholders traditionally active in tobacco control and substance use prevention in the cannabis policy process and assess usefulness of the CLCPS as a tool for community engagement. The project will seek to survey all California Tobacco Control Program (CTCP) grantees, county health officers, planning officials as well as major voluntary organizations and community substance abuse prevention advocates. It will also carry out qualitative interviews with selected stakeholders and policymakers. Grantees from communities of color will be a special focus. Surveys will be conducted in Years 1 & 3 to establish a baseline and assess progress. Research will seek to clarify knowledge, attitudes and practices regarding cannabis policy, practical barriers to community engagement, and perceptions and use of the Cannabis Local Policy Scorecards, and to directly apply findings to implementation. Findings will be shared with key policymakers, community stakeholders, CTCP, county health officers, the Dept. of Cannabis Control and others.
Plagioscion casattii Aguilera & Rodrigues 2001
Creators: name: Langeani, Francisco
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Perciformes
Sciaenidae
Plagioscion
Plagioscion casattii

description: Plagioscion casattii Aguilera & Rodrigues (2001).
Paratypes: 1 lot, 2 specimens; DZSJRP 5482, río Orinoco (obtained at the Ciudad Bolívar fish market), Bolívar, Venezuela, col. O. Aguilera, 15 February 2000.
description: Published as part of Langeani, Francisco, 2017, Annotated catalog of the type specimens deposited at the fish collection of the " Universidade Estadual Paulista, Câmpus de São José do Rio Preto ", São Paulo, Brazil (DZSJRP), pp. 435-460 in Zootaxa 4319 (3) on page 456, DOI: 10.11646/zootaxa.4319.3.2, http://zenodo.org/record/890303
Targeting organelle homeostasis in non-small cell lung cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Lung cancer is the leading cause of deaths by cancer worldwide, and tobacco use is a well-established risk factor. Lung carcinomas associated with exposure to commercial tobacco products often carry mutations which make them highly aggressive and difficult to treat. These therapy-resistant tumors represent about 20% of diagnosed patients. Finding therapies for these patients is an urgent unmet clinical need. A characteristic of these therapy resistant tumors is their dependence of high energy production for survival. Limiting their ability to obtain energy appears to kill these tumor cells while sparing normal cells. We have discovered that an inhibitor of an enzyme called N-myristoyltransferase (NMT) is effective at specifically killing these highly metabolic tumor cells. We are interested in understanding the mechanism by which this takes place and test the effectiveness of this inhibitor at decreasing tumor size in mice implanted with human cells and tumors from these patients. Importantly, this inhibitor is currently in clinical trial for lymphoma. Therefore, testing this experimental drug in lung cancers without available therapeutic options is timely and highly significant. Understanding how the inhibitor kills cancer cells will also inform further efforts to translate these findings into the clinic.
Melieria nigritarsis Becker 1903
Creators: name: El-Hawagry, Magdi S.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Ulidiidae
Melieria
Melieria nigritarsis

description: Melieria nigritarsis Becker, 1903
Melieria nigritarsis Becker, 1903: 130. Syntypes. Egypt (Damietta and Fayoum) (ZMHB). Distribution. AF: south to Namibia, Kenya. PA: Egypt, Iran, Iraq, Israel, Kazakhstan, Ukraine, European Russia, Saudi Arabia, Siberia, Tunisia, Turkmenistan, United Arab Emirates, Uzbekistan, western China. Egyptian localities. Coastal Strip: Alexandria, Cleopatra, Dekheila, Mariout. Fayoum: Eastern Desert: Ismailiya. Fayoum City. Lower Nile Valley and Delta: Abu Rawash, Helwan, Kafr Hakim, Kerdassa. Western Desert: Abu Mongar, Dakhla Oasis, Kharga Oasis.
Plants from which flies were swept. Cogon or Satintail grass (Imperata sp.).
Dates of collection. February to October.
description: Published as part of El-Hawagry, Magdi S., 2017, Catalogue of Egyptian Tephritoidea (Diptera: Schizophora: Acalyptratae), pp. 151-190 in Zootaxa 4299 (2) on page 179, DOI: 10.11646/zootaxa.4299.2.1, http://zenodo.org/record/843233
Water quality management : New Jersey's vanishing options
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1973

description: "Water Quality Management: New Jersey's Vanishing Options"  is the its eighth report of the County and Municipal Government Study Commission. This study continues the examination of local government's structure and functions in New Jersey. The Commission notes that in the water management function the State plays a preeminent role and that its responsibilities are likely to increase in the future. Thus, the recommendations in this report are addressed to remedial actions at all levels of government and begin with the overhaul of the current statutory base.This report concludes that New Jersey needs strong, comprehensive legislation upon which to base a formal system for managing water quality issues.
A neural circuit mechanism for the dose dependent effects of nicotine on reward and aversion
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: A predominant hypothesis for nicotine addiction is that nicotine “hijacks” natural reward processes in the brain. Like other addictive drugs, nicotine stimulates the dopamine system, and this action is critical for establishing and maintaining the tobacco smoking habit. While much research has been conducted to understand how the brain responds to nicotine to generate feelings of pleasure and reward, it is less well understood how a high dose of nicotine can induce unpleasant feelings that lead to aversion. Indeed, in humans, nicotine is also highly noxious, particularly at higher doses, and aversive reactions to nicotine can decrease the likelihood of developing a tobacco habit in many first-time smokers. Similarly, research in animal models have shown that the behavioral response to nicotine is dose-dependent; at low doses, nicotine is reinforcing and high doses it promotes aversion. Preliminary research results that were obtained with support of a TRDRP Pilot Award (26IP-0035) suggest that a low, rewarding dose of nicotine activates dopamine neurons whereas a higher, aversive dose inhibits them. Based on this finding and a previous study from our lab, which suggests that separate dopamine pathways are differentially modulated by rewarding and aversive stimuli (de Jong et al., 2019; Neuron), an intriguing possibility is that different dopamine pathways contribute to the dose dependent effects of nicotine reward and aversion. To study this, we will leverage the unique pharmacological profile of nicotine and perform intravenous infusions of nicotine in tandem with in vivo fiber photometry in awake, behaving mice to determine how different doses of nicotine modulate dopamine release in different downstream projection targets. Additionally, we will examine inhibitory inputs from the laterodorsal tegmentum as a potential upstream regulator of dopamine cell activity and promising component for understanding the circuit mechanisms that contribute to nicotine aversion. Together, the proposed research will provide a mechanistic circuit-level understanding of the pharmacological and neurobiological processes that contribute to nicotine’s dose-dependent effects on reward and aversion. Such knowledge may be important for the development of novel therapeutic agents for tobacco dependence that act not by blocking nicotine reward but by enhancing nicotine avoidance.
Report of W.P.A. traffic safety survey, Plainfield, New Jersey.
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1937

description: The Plainfield Area Safety Council conducted this traffic survey of all streets andhighways in Plainfield to support their goal of making Plainfield a safercommunity for both motorists and pedestrians.This survey, conducted under the supervision of Mr. Eugene A. Barton, includes the following: Collection of accident fact data, engineering study of streets, highways and intersections, enforcementand educational studies and recommendations.
Chamaecrista ensiformis H. S. Irwin & Barneby, Mem.
Creators: name: Silva, Lucas
name: Thomaz, Luciana Dias
name: Dutra, Valquíria Ferreira
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Fabales
Fabaceae
Chamaecrista
Chamaecrista ensiformis

description: 1.1 Chamaecrista ensiformis (Vell.) H.S. Irwin & Barneby, Mem. New York Bot. Gard. 35: 642. 1982.
(Fig. 4J)
Arbustos a árvores, 2,5-5 m alt.; ramos glabros, inermes. Estípulas 14-26 × 6-12 mm, ovadas, livres, decíduas. Folhas paripinadas, 4-folioladas; pecíolos 51-79 mm compr., glabrescentes; raque foliar 28-51 mm compr., glabra; folíolos 78-123 × 40-69 mm, elípticos, base cuneada, ápice agudo, margem inteira, faces adaxial e abaxial glabras; nectários foliares entre os pares de folíolos, pateliformes. Inflorescências racemosas, 8-15-floras, caulifloras. Flores assimétricas, pentâmeras, não ressupinadas; cálice dialissépalo, pentâmero, 3-5 × 1,5-2 mm, sépalas lanceoladas, cremes a amarelas, tomentosas; corola dialipétala, 4 pétalas externas 14-16 × 6-7 mm, 1 vexilar interna 20 × 8 mm, elípticas, amarelas; estames 10, livres, 5- 5, 8 mm compr., homodínamos; filetes amarelos; anteras uniformes, 3,2-5 mm compr., poricidas, estaminódios ausentes; ovário ca. 5 mm compr., séssil, tomentoso; estilete ca. 11 mm compr., tomentoso. Legumes 9-7 × 0,9-1,5 cm, glabros, elasticamente deiscentes. Sementes 13-14, largamente elípticas, 10-10,9 × 8,4-8,8 mm, marrons.
Espécie endêmica do Brasil ocorrendo nas regiões Norte (AM, PA, TO), Nordeste (AL, BA, CE, MA, PB, PE, PI, RN, SE), Centro-Oeste (GO, MT) e Sudeste (ES, MG, RJ, SP), nos Domínios Fitogeográficos da Amazônia, Caatinga, Mata Atlântica e Cerrado (BFG 2015, material suplementar). No PNMJ ocorre em Floresta Inundável e Floresta Não Inundável, em borda de estrada. Coletada com flores em janeiro, abril e julho com frutos em janeiro e outubro.
O gênero Chamaecrista possui como características as folhas paripinadas, inflorescência racemosa, flores amarelas, legumes elasticamente deiscentes (Rando 2009). No PNMJ, C. ensiformis difere-se das demais espécies do gênero Chamaecrista por possuir porte arbustivo (vs. herbáceo a subarbustivo), pela presença de inflorescências (vs. flores solitárias), caulifloria e estípulas maiores (14-26 mm compr. vs. 3-12 nas demais espécies).
Material examinado: BRASIL, Espírito Santo, Vila Velha, Parque Natural Municipal de Jacarenema, 21.X.1987, O. J. Pereira et al. 1199 (VIES); 01.IV.2012, L. A. Silva (VIES); 25.VII.2012, L. A. Silva 228 (VIES); 10. I.2013, L. A. Silva 293 (VIES); 10. I.2013, L. A. Silva 294 (VIES); 10. I.2013, L. A. Silva 295 (VIES).
description: Published as part of Silva, Lucas, Thomaz, Luciana Dias & Dutra, Valquíria Ferreira, 2018, Leguminosae no Parque Natural Municipal de Jacarenema, Vila Velha, Espírito Santo, Brasil, pp. 261-289 in Iheringia, Série Botânica 73 (3) on page 268, DOI: 10.21826/2446-8231201873305, http://zenodo.org/record/10950818
Real-time predictors of nicotine and cannabis vaping among young adults
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Nicotine and cannabis vaping among young adults has grown dramatically in the last five years. Approximately 700,000 California young adults reported vaping nicotine in the past month. Co-vaping of both substances is common, and vaping either substance is associated with use of cigarettes and other tobacco products, putting users at risk for tobacco-related diseases. Despite young adults’ interest in quitting vaping and a recent call for vaping cessation interventions, we lack evidence-based personalized interventions, particularly those leveraging technology to best reach young people. The goal of this proposal is to examine real-time predictors of nicotine and cannabis vaping among young adults (18-29 years old) and to understand cessation needs and preferences for a future smartphone-based intervention. Our multidisciplinary team brings together expertise in tobacco control, cannabis use, and mobile health to address two specific aims. First, we will use an existing NIH-funded smartphone app (the Eureka) to collect real-time data on vaping occurrences and situational factors among 100 young adult vapers. Based on our preliminary studies, we will examine both intrapersonal (e.g., craving, emotion) and environmental predictors (e.g., location, triggers) for vaping each susbtance. Second, we will conduct interviews with a subsample of 20 participants to understand needs for cessation support and recommendations for a smartphone-based intervention. This study addresses a major public health concern (i.e., the vaping epidemic) in a priority population for tobacco control (i.e., young adults). By leveraging smartphone technology and combining different types of data, this study will advance our understanding of real-time predictors of vaping to inform the development of innovative intervention strategies addressing these predictors to curb the vaping epidemic among young adults. Findings will lay the groundwork for a future proposal to develop and evaluate an intervention that delivers personalized supports for vaping cessation via smartphone. Thus, this study responds to the TRDRP’s research priority in “social and behavioral prevention and treatment” and informs the Endgame Policy Platform by moving California closer to providing “population-wide comprehensive, barrier-free, and widely promoted cessation support.”
Identifying a primary motivator of continued tobacco use in the schizophrenia population
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Smoking remains the most important preventable cause of premature death. Despite the fact that smoking causes serious health problems (such as cardiovascular disorders, chronic respiratory disorders, and lung cancer) many people continue to smoke. Individuals suffering from schizophrenia smoke at much higher rates than the general population, and find it more difficult to quit, contributing to widening health inequalities. A number of hypotheses have been proposed to explain the relationship between high smoking rates and schizophrenia, mostly relating to self-medication primarily for the negative symptoms of schizophrenia. A core feature of schizophrenia is cognitive dysfunction. Nicotine is the main active ingredient in tobacco, and although it is an addictive substance, it has also been found to enhance cognitive function in individuals, including schizophrenia patients. It has therefore been hypothesized that schizophrenics smoke heavily, despite negative health consequences, to self-medicate cognitive deficits. Abstinence would deprive them of the beneficial effects, explaining the hesitation among people with schizophrenia to pursue smoking cessation. Understanding the mechanisms underlying nicotine-induced cognitive enhancement in schizophrenia patients may provide novel insights into the etiology and treatment of the condition, with the added benefit of facilitating smoking cessation among people with schizophrenia. This research proposal is to understand how nicotine enhances memory function in individuals suffering from schizophrenia for the development of smoking cessation treatment among people with schizophrenia.
Role of pulmonary innate lymphoid type II cells in perinatal vaping-induced asthma in offspring
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: It is well established that the human gut microbiome performs many critical functions including the development and regulation of the immune system. Emerging evidence suggests that disruption of gut microbiome increases the risk of many chronic conditions including an increased predisposition to allergic asthma. Preliminary data from our nicotine exposure rodent model and studies by other investigators suggest that perinatal nicotine exposure alters the gut microbiome of pregnant women and the consequent short chain fatty acid (SCFA) levels produced by the gut microorganisms. However, the effect of perinatal nicotine exposure by traditional or e-cigs on maternal/offspring gut microbiome and the consequent SCFA profiles, and offspring asthma has not been determined. This is highly relevant since 1) vaping among women of reproductive age group has increased sharply and 2) in adult rodent models of allergic asthma, by modulating SCFA profile we have recently documented complete mitigation of house dust mite-induced allergic asthma. We hypothesize that perinatal inhaled nicotine predisposes offspring to allergic asthma, which, at least in part is mediated via nicotine’s effects on specialized immune cells, known as the pulmonary group 2 innate lymphoid cells or ILC2s, which have been implicated to play a critical role in allergic asthma in adults. We further hypothesize that modulation of maternal gut microbiota during pregnancy and lactation can effectively block perinatal nicotine vaping-induced asthma. Our research team with expertise in e-cig vaping, nicotine toxicology, and allergic asthma will use cutting-edge techniques to determine the effect of perinatal nicotine vaping on 1) maternal gut microbiome and maternal/offspring SCFA profile; 2) molecular mechanisms regulating the development and function of ILC2s; and 3) whether modulation of maternal gut microbiome during pregnancy and lactation to high butyrate producing microorganisms blocks nicotine-vaping induced allergic asthma in the exposed offspring. This work is likely to provide new objective information for Endgame Policy Platform to enlighten public on the long lasting dangers of vaping during pregnancy and lactation. Importantly, it can also potentially lead to novel, safer, effective mechanism-based and relatively easily implementable therapies for perinatal inhaled nicotine-induced asthma.
Melieria omissa
Creators: name: El-Hawagry, Magdi S.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Ulidiidae
Melieria
Melieria omissa

description: Melieria omissa (Meigen, 1826)
Ortalis omissa Meigen, 1826: 274. Types apparently lost. Germany (Berlin).
Melieria omissa misrica Steyskal, 1968: 123. Holotype. Egypt (Helwan) (EFC). Distribution. PA: Austria, Belgium, Czech Republic, Denmark, Egypt, France, Germany, Great Britain, Greece, Hungary, Iran, Italy, Japan, Korea, Latvia, Moldavia, Mongolia, Netherlands, Poland, Romania, Russia, Saudi Arabia, Sicily, Slovakia, Spain, Switzerland, Ukraine.
Egyptian localities. Eastern Deser: Gebel Asfar, Wadi Sayal. Fayoum: Fayoum City, Kom Osheem, Wadi El- Rayian. Lower Nile Valley and Delta: Barrage, Roudah.
Plants from which flies were swept. Cogon or Satintail grass (Imperata sp.) and wild sugarcane (Saccharum spontaneum L.).
Dates of collection. March to December.
description: Published as part of El-Hawagry, Magdi S., 2017, Catalogue of Egyptian Tephritoidea (Diptera: Schizophora: Acalyptratae), pp. 151-190 in Zootaxa 4299 (2) on page 179, DOI: 10.11646/zootaxa.4299.2.1, http://zenodo.org/record/843233
Mechanism underlying perinatal e-cigarette smoke/nicotine-induced cardiac dysfunction in offspring
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: There has been a sharp rise in vaping, mainly due to the perception among users that vaping is relatively harmless because it does not contain smoke. The result is increased exposure of developing fetuses to potential harm from nicotine and flavorings in the inhaled vapors. Due to growing concerns, the Food and Drug Administration has recently recommended a ban on most flavored electronic cigarettes (e-cigs). However, the effective implementation of this ban is problematic, has been stalled in many states, and some flavored e-cigs remain freely accessible. Thus far, there have been very few systematic investigations on the potential adverse health effects of vaping on the developing heart. Our preliminary data in animals show that nicotine can have harmful effects on the developing heart. In a rat model, we exposed pregnant dams to nicotine and found that the hearts of offspring have structural and functional effects, making them more prone to poor recovery from heart attacks. These data led us to wonder whether exposure to vaping via e-cigs might also produce the same adverse health effects. Our studies will address these questions using established models and experienced investigators. Specifically, we propose investigating whether vaping nicotine and/or selected e-cig flavorings, e.g., menthol and tobacco, while pregnant can have long-term effects on the developing heart and, if so, what are the underlying mechanisms involved. The proposed studies will provide a novel framework for understanding an individual’s predisposition to heart disease, i.e., in addition to other factors that are unhealthy for heart health, an individual’s heart disease susceptibility might also be related to ancestral smoke/nicotine exposure, heralding a novel paradigm for personalized heart disease susceptibility, prevention, and treatment. Overall, our studies will advance the understanding of how adverse effects of vaping affect the developing heart, and will not just inform public policy-makers but will arm them with objective evidence as they work to protect our society and our offspring from the harmful effects of vaping.
NextGen Smoke and Vape Free Latinx Scholars Program
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The proposed partnership between San Diego State University (SDSU, doctoral-granting institution) and Southwestern College (SWC, CA Community College) will provide a student-centered, research-intensive mentoring program for undergraduate students, focusing on tobacco-related health disparities and health equity. Our program goal is to build a diverse and equitable pipeline of tobacco control scholars.
 Our project focuses on training students who identify as Latinx, are first-time-to-college students, and are receiving financial aid. Southwestern College is a Hispanic-Serving Institution with almost 70% of students identifying as Latinx and where 86% of Latinx students receive some form of financial aid. In addition, 86% of Latinx students receive some form of financial aid. We plan to train 15 undergraduate transfer scholars over the project period. Tobacco-focused mentors at SDSU, a Hispanic-serving Institution, focus on a wide range of research topics with diverse and interdisciplinary backgrounds, including psychology, sociology, public health, anthropology, communications, biology, and public policy. Mentors are involved in grant-funded health disparities research and successfully work with students through the doctoral level. Projects address vaping and tobacco product behaviors, secondhand and thirdhand smoke, tobacco product waste, equity implications of tobacco policy, pulmonary biology, and tobacco-related diseases. Researcher mentors also have strong community and advocacy partnerships, with current work disseminating tobacco control messages to priority populations and working with both local and state legislators on tobacco-control policies. Further, our team has a wealth of experience working with student career development. For example, many team members have worked with students on student supplement awards and have led or completed other nationally recognized training programs. Our proposed tobacco-related health disparities and health equity research program will interface with existing experiences and student clubs to also include internships and professional development (e.g., conference presentations, academic writing, interview/resume workshops).