Additional file 4 of Effects of semaglutide on risk of cardiovascular events across a continuum of cardiovascular risk: combined post hoc analysis of the SUSTAIN and PIONEER trials
Creators: name: Husain, Mansoor
name: Bain, Stephen C.
name: Holst, Anders Gaarsdal
name: Mark, Thomas
name: Rasmussen, Søren
name: Lingvay, Ildiko
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy

description: Additional file 4: Table S4. Baseline characteristics, observation times and number of events in subjects receiving semaglutide in individual SUSTAIN (A) and PIONEER (B) trials, and in subjects receiving comparators (C). A: *The CV risk score was derived as the predicted values from a Cox proportional hazard regression of time to first MACE, where all significant baseline predictors, except randomized treatment, were included as explanatory variables. †eGFR was estimated using the CKD-EPI formula. Data are mean (SD) or n (%). bpm, beats per minute; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; CV, cardiovascular; eGFR, estimated glomerular filtration rate; HbA1c, glycated hemoglobin; JP, Japanese trial; LDL-C, low-density lipoprotein cholesterol; MACE, major adverse cardiovascular events; MI, myocardial infarction; Mono, monotherapy; NHYA, New York Heart Association; OAD, oral antidiabetes drug; SBP, systolic blood pressure; SD, standard deviation. B: *The CV risk score was derived as the predicted values from a Cox proportional hazard regression of time to first MACE, where all significant baseline predictors, except randomized treatment, were included as explanatory variables. †eGFR was estimated using the CKD-EPI formula. Data are mean (SD) or n (%). bpm, beats per minute; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; CV, cardiovascular; eGFR, estimated glomerular filtration rate; HbA1c, glycated hemoglobin; LDL-C, low-density lipoprotein cholesterol; MACE, major adverse cardiovascular events; MI, myocardial infarction; NHYA, New York Heart Association; SBP, systolic blood pressure; SD, standard deviation. C: *The CV risk score was derived as the predicted values from a Cox proportional hazard regression of time to first MACE, where all significant baseline predictors, except randomized treatment, were included as explanatory variables. †eGFR was estimated using the CKD-EPI formula. Data are mean (SD) or n (%). bpm, beats per minute; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; CV, cardiovascular; DPP-4i, dipeptidyl peptidase-4 inhibitor; eGFR, estimated glomerular filtration rate; GLP-1RA, glucagon-like peptide-1 receptor agonist; HbA1c, glycated hemoglobin; HF, heart failure; LDL-C, low-density lipoprotein cholesterol; MACE, major adverse cardiovascular events; MI, myocardial infarction; NHYA, New York Heart Association; OAD, oral antidiabetes drug; SD, standard deviation; SGLT-2i, sodium–glucose co-transporter-2 inhibitor.