Additional file 1 of Association analysis and functional annotation of imputed sequence data within genomic regions influencing resistance to gastro-intestinal parasites detected by an LDLA approach in a nucleus flock of Sarda dairy sheep
Creators: name: Casu, Sara
name: Usai, Mario Graziano
name: Sechi, Tiziana
name: Salaris, Sotero L.
name: Miari, Sabrina
name: Mulas, Giuliana
name: Tamponi, Claudia
name: Varcasia, Antonio
name: Scala, Antonio
name: Carta, Antonello
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Figure S1. Graphical comparison of LDLA and WGS-based data association analyses within the QTL region Q_01_1 (chromosome 1). The figure shows the test statistics (− log10(nominal p-values) profile of the LDLA analysis (LDLA Mapping, red line) and Manhattan plot of the association analysis based on imputed genotypes from re-sequenced animals (WGS Mapping, blue dots) in the QTL region Q_01_1 (chromosome 1, imputation from 99 to 100 Mb of the Ovis aries genome assembly v4.0). Figure S2. Graphical comparison of LDLA and WGS-based data association analyses within the QTL region Q_02_1 (chromosome 2). The figure shows the test statistics (− log10(nominal p-values) profile of the LDLA analysis (LDLA Mapping, red line) and Manhattan plot of the association analysis based on imputed genotypes from re-sequenced animals in the QTL region Q_02_1 (chromosome 2, imputation from 135 to 137 Mb of the Ovis aries genome assembly v4.0). Figure S3. Graphical comparison of LDLA and WGS-based data association analyses within the QTL region Q_02_2 (chromosome 2). The figure shows the test statistics (− log10(nominal p-values) profile of the LDLA analysis (LDLA Mapping, red line) and Manhattan plot of the association analysis based on imputed genotypes from re-sequenced animals in the QTL region Q_02_2 (chromosome 2, imputation from 212 to 214 Mb of the Ovis aries genome assembly v4.0). Figure S4. Graphical comparison of LDLA and WGS-based data association analyses within the QTL region Q_04_1 (chromosome 4). The figure shows the test statistics (− log10(nominal p-values) profile of the LDLA analysis (LDLA Mapping, red line) and Manhattan plot of the association analysis based on imputed genotypes from re-sequenced animals in the QTL region Q_04_1 (chromosome 4, imputation from 4 to 10 Mb of the Ovis aries genome assembly v4.0). Figure S5. Graphical comparison of LDLA and WGS-based data association analyses within the QTL region Q_06_1 (chromosome 6). The figure shows the test statistics (− log10(nominal p-values) profile of the LDLA analysis (LDLA Mapping, red line) and Manhattan plot of the association analysis based on imputed genotypes from re-sequenced animals in the QTL region Q_06_1 (chromosome 6, imputation from 12 to 14 Mb of the Ovis aries genome assembly v4.0). Figure S6. Graphical comparison of LDLA and WGS-based data association analyses within the QTL region Q_07_1 (chromosome 7). The figure shows the test statistics (− log10(nominal p-values) profile of the LDLA analysis (LDLA Mapping, red line) and Manhattan plot of the association analysis based on imputed genotypes from re-sequenced animals in the QTL region Q_07_1 (chromosome 7, imputation from 87 to 89 Mb of the Ovis aries genome assembly v4.0). Figure S7. Graphical comparison of LDLA and WGS-based data association analyses within the QTL region Q_12_1 (chromosome 12). The figure shows the test statistics (− log10(nominal p-values) profile of the LDLA analysis (LDLA Mapping, red line) and Manhattan plot of the association analysis based on imputed genotypes from re-sequenced animals in the QTL region Q_12_1 (chromosome 7, imputation from 35 to 42 Mb of the Ovis aries genome assembly v4.0). Figure S8. Graphical comparison of LDLA and WGS-based data association analyses within the QTL region Q_15_1 (chromosome 15). The figure shows the test statistics (− log10(nominal p-values) profile of the LDLA analysis (LDLA Mapping, red line) and Manhattan plot of the association analysis based on imputed genotypes from re-sequenced animals in the QTL region Q_15_1 (chromosome 15, imputation from 33 to 35 Mb of the Ovis aries genome assembly v4.0). Figure S9. Graphical comparison of LDLA and WGS-based data association analyses within the QTL region Q_19_1 (chromosome 19). The figure shows the test statistics (− log10(nominal p-values) profile of the LDLA analysis (LDLA Mapping, red line) and Manhattan plot of the association analysis based on imputed genotypes from re-sequenced animals in the QTL region Q_19_1 (chromosome 19, imputation from 18 to 32 Mb of the Ovis aries genome assembly v4.0). Figure S10. Graphical comparison of LDLA and WGS-based data association analyses within the QTL region Q_20_1 (chromosome 20). The figure shows the test statistics (− log10(nominal p-values) profile of the LDLA analysis (LDLA Mapping, red line) and Manhattan plot of the association analysis based on imputed genotypes from re-sequenced animals in the QTL region Q_20_1 (chromosome 20, imputation from 16 to 37 Mb of the Ovis aries genome assembly v4.0).