cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Microcavia H. Gervais and Ameghino 1880
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Caviidae
Microcavia

description: Microcavia H. Gervais and Ameghino, 1880. Mamm. Fos. Am. Sud., p. 50. COMMENT: Reviewed by Huckinghaus, 1961, Z. Wiss. Zool., 166:72-84, and Cabrera, 1961:570-573. ISIS NUMBER: 5301410019004000000.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Rodentia (Part 6), pp. 560-594 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 574, DOI: 10.5281/zenodo.7353039
description: {"references": ["Huckinghaus, F. 1961. Vergleichende Untersuchungen uber die Formenmannigfaltigkeit der Unterfamilie Caviinae Murray 1886. (Ergebnisse der Sudamerikaexpedition Herre / Rohrs 1956 - 1957). Zeitschrift fur Wissenschaftliche Zoologie, 166: 1 - 98, 62 pls."]}
Transcription factor and microRNA interactions in lung cells: an inhibitory link between NK2 homeobox 1, miR-200c and the developmental and oncogenic factors Nfib and Myb
Creators: name: Tagne, Jean-Bosco
name: Mohtar, Omar R.
name: Campbell, Joshua D.
name: Lakshminarayanan, Meenakshi
name: Huang, Jingshu
name: Hinds, Anne C.
name: Lu, Jining
name: Ramirez, Maria I.
Publisher: name: Columbia University
Year: 2015
Subjects: Gene expression
Epithelial cells
Genetic transcription--Research
Cytology

description: Background:
The transcription factor NK2 homeobox 1 (Nkx2-1) plays essential roles in epithelial cell proliferation and differentiation in mouse and human lung development and tumorigenesis. A better understanding of genes and pathways downstream of Nkx2-1 will clarify the multiple roles of this critical lung factor. Nkx2-1 regulates directly or indirectly numerous protein-coding genes; however, there is a paucity of information about Nkx2-1-regulated microRNAs (miRNAs).

Methods and results:
By miRNA array analyses of mouse epithelial cell lines in which endogenous Nkx2-1 was knocked-down, we revealed that 29 miRNAs were negatively regulated including miR-200c, and 39 miRNAs were positively regulated by Nkx2-1 including miR-1195. Mouse lungs lacking functional phosphorylated Nkx2-1 showed increased expression of miR-200c and alterations in the expression of other top regulated miRNAs. Moreover, chromatin immunoprecipitation assays showed binding of NKX2-1 protein to regulatory regions of these miRNAs. Promoter reporter assays indicated that 1kb of the miR-200c 5′ flanking region was transcriptionally active but did not mediate Nkx2-1- repression of miR-200c expression. 3′UTR reporter assays support a direct regulation of the predicted targets Nfib and Myb by miR-200c.

Conclusions:
These studies suggest that Nkx2-1 controls the expression of specific miRNAs in lung epithelial cells. In particular, we identified a regulatory link between Nkx2-1, the known tumor suppressor miR-200c, and the developmental and oncogenic transcription factors Nfib and Myb, adding new players to the regulatory mechanisms driven by Nkx2-1 in lung epithelial cells that may have implications in lung development and tumorigenesis.

Keywords:

microRNA Transcription factors Gene expression Lung epithelial cells Targets
The association of alcohol consumption with
mammographic density in a multiethnic urban
population
Creators: name: Quandt, Zoe
name: Flom, Julie D.
name: Tehranifar, Parisa
name: Reynolds, Diane
name: Terry, Mary Beth
name: McDonald, Jasmine A.
Publisher: name: Columbia University
Year: 2015
Subjects: Breast--Cancer--Etiology
Minorities--Health and hygiene
Alcohol--Physiological effect
Public health

description: Background:
Alcohol consumption is associated with higher breast cancer risk. While studies suggest a modest association between alcohol intake and mammographic density, few studies have examined the association in racial/ethnic minority populations.

Methods:
We assessed dense breast area and total breast area from digitized film mammograms in an urban cohort of African American (42%), African Caribbean (22%), white (22%), and Hispanic Caribbean (9%) women (n = 189, ages 40-61). We examined the association between alcohol intake and mammographic density (percent density and dense area). We used linear regression to examine mean differences in mammographic density across alcohol intake categories. We considered confounding by age, body mass index (BMI), hormone contraceptive use, family history of breast cancer, menopausal status, smoking status, nativity, race/ethnicity, age at first birth, and parity.

Results:
Fifty percent currently consumed alcohol. Women who consumed >7 servings/week of alcohol, but not those consuming ≤7 servings/week, had higher percent density compared to nondrinkers after full adjustments (servings/week >7 β = 8.2, 95% Confidence Interval (CI) 1.8, 14.6; ≤7 β = -0.5, 95% CI -3.7, 2.8). There was a positive association between high alcohol intake and dense area after full adjustments (servings/week >7 β = 5.8, 95% CI -2.7, 14.2; ≤7 β = -0.1, 95% CI -4.4, 4.2). We did not observe race/ethnicity modification of the association between alcohol intake and percent density. In women with a BMI of <25 kg/m2, drinkers consuming >7 servings/week of alcohol had a 17% increase in percent density compared to nondrinkers (95% CI 5.4, 29.0) and there was no association in women with a BMI ≥ 25 kg/m2 (BMI ≥ 25-30 kg/m2 > 7 β = 5.1, 95% CI -8.5, 18.7 and BMI > 30 kg/m2 > 7 β = 0.5, 95% CI -6.5, 7.5) after adjusting for age and BMI (continuous).

Conclusion:
In a racially/ethnically diverse cohort, women who consumed >7 servings/week of alcohol, especially those with a BMI < 25 kg/m2, had higher percent density.

Keywords:

Mammographic breast density Alcohol consumption Breast cancer
Microcavia australis
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Caviidae
Microcavia
Microcavia australis

description: Microcavia australis (I. Geoffroy and d'Orbigny, 1833). Mag. Zool. Paris, p. 3. TYPE LOCALITY: Argentina, Patagonia, vicinity of the lower part of the Rio Negro. DISTRIBUTION: Argentina between Jujuy and Santa Cruz Provs.; Aisen Prov. (Chile); possibly extreme S. Bolivia. COMMENT: Reviewed by Thomas, 1921, Ann. Mag. Nat. Hist., 9(7):445. ISIS NUMBER: 5301410019004001001.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Rodentia (Part 6), pp. 560-594 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 574, DOI: 10.5281/zenodo.7353039
A Swiss Pocket Knife for Computability
Creators: name: Jones, Neil D.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Programming Languages (cs.PL)
subject: Computational Complexity (cs.CC)
subject: FOS: Computer and information sciences

description: This research is about operational- and complexity-oriented aspects of classical foundations of computability theory. The approach is to re-examine some classical theorems and constructions, but with new criteria for success that are natural from a programming language perspective. Three cornerstones of computability theory are the S-m-ntheorem; Turing's "universal machine"; and Kleene's second recursion theorem. In today's programming language parlance these are respectively partial evaluation, self-interpretation, and reflection. In retrospect it is fascinating that Kleene's 1938 proof is constructive; and in essence builds a self-reproducing program. Computability theory originated in the 1930s, long before the invention of computers and programs. Its emphasis was on delimiting the boundaries of computability. Some milestones include 1936 (Turing), 1938 (Kleene), 1967 (isomorphism of programming languages), 1985 (partial evaluation), 1989 (theory implementation), 1993 (efficient self-interpretation) and 2006 (term register machines). The "Swiss pocket knife" of the title is a programming language that allows efficient computer implementation of all three computability cornerstones, emphasising the third: Kleene's second recursion theorem. We describe experiments with a tree-based computational model aiming for both fast program generation and fast execution of the generated programs.
description: In Proceedings Festschrift for Dave Schmidt, arXiv:1309.4557
British Columbia Legislative Assembly sessional clipping book (1891-02)
Creators: name: :Unav
Publisher: name: University of Victoria Libraries
Year: 2022
Subjects: subject: British Columbia. Legislative Assembly
valueUri: http://id.worldcat.org/fast/600765
subject: Law
valueUri: http://id.worldcat.org/fast/993678
subject: FOS: Law
subject: Politics and government
valueUri: http://id.worldcat.org/fast/1919741

description: These Sessional Clippings books cover the period 1891 to 1972, and include newspaper accounts written by various legislative reporters who covered debates occurring in the British Columbia Legislative Assembly. Transcripts of debates of the Legislative Assembly (Hansard) were not published in B.C. until 1970; hence these "Sessional Clipping Books" augment the "Journals", the record of daily proceedings of the Legislative Assembly. Selected clippings from various newspapers including the Vancouver Sun, the Vancouver Province, the Colonist, and the Times newspapers, relating to the newspaper reports concerning activities of the Legislature. The original sessional clippings books comprise 351 ledger size print volumes, held at the Legislative Library in Victoria BC. The print volumes were microfilmed onto 26 reels in 1977 under a Tri University Libraries (TRIUL) project by Precision Micrographic Services (Vancouver, B.C.), with the permission of the Legislative Library, Victoria, British Columbia. This digital collection was created by scanning the 26 microfilm reels.
Orientation dependence of energy absorption and relaxation dynamics of $\text{C}_{60}$ in fs-laser pulses: How round is $\text{C}_{60}$?
Creators: name: Fischer, M.
name: Handt, J.
name: Seifert, G.
name: Schmidt, R.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Atomic and Molecular Clusters (physics.atm-clus)
subject: FOS: Physical sciences

description: By means of non-adiabatic quantum molecular dynamics it is shown, that the amount of energy deposited into $\text{C}_{60}$ by a short laser field strongly depends on the molecular orientation with respect to the laser polarization direction. In consequence, subsequent electron-vibration coupling leads to different nuclear relaxation mechanisms with mainly three pathways: (1) excitation of giant $\text{A}_g(1)$ modes ("breathing"), (2) formation of deformed cage-like complexes ("isomers"), fragmentation predominantly into two large pieces ("fission"). The results are in accord with and explain nicely already existing experimental data. Future experiments are proposed to confirm the detailed predictions.
description: 5 pages, 3 figures
UA-FLP models and instances
Creators: name: Domínguez-Casasola, Saúl
name: Velasco, Jonás
name: Urbán-Rivero, Luis Eduardo
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 401404
subject: Industrial engineering
classificationCode: 490304
subject: Optimisation

description: The Facility Layout Problem (FLP) is a classic problem for industrial engineers and work area designers, taking relevance because of its direct impact on productivity and efficiency in productive systems. On the other hand, we face the Unequal Area Facility Layout Problem (UA-FLP) when the departments may have different areas. This study aims to propose two mixed integer linear programming formulations for the UA-FLP and use them to solve some academic instances. In particular, there is a case study in which we relocated the departments in an SME of dairy products to make the company more profitable by minimizing the total cost of movements between areas. This project was successful, obtaining excellent results, which becomes relevant because of its potential replication in other SMEs, making their production systems more efficient and their local economies more vigorous.
Residential environment and breast cancer incidence and mortality: a systematic review and meta-analysis
Creators: name: Akinyemiju, Tomi F.
name: Genkinger, Jeanine M.
name: Farhat, Maggie
name: Wilson, Adrienne
name: Gary-Webb, Tiffany L.
name: Tehranifar, Parisa
Publisher: name: Columbia University
Year: 2015
Subjects: Environmental impact analysis
Breast--Cancer--Mortality
Breast--Cancer--Etiology
Public health

description: Background:
Factors beyond the individual level such as those characterizing the residential environment may be important to breast cancer outcomes. We provide a systematic review and results of meta-analysis of the published empirical literature on the associations between breast cancer risk and mortality and features of the residential environment.

Methods:
Using PRISMA guidelines, we searched four electronic databases and manually searched the references of selected articles for studies that were published before June 2013. We selected English language articles that presented data on adult breast cancer incidence or mortality in relation to at least one area-based residential (ABR) independent variable.

Results:
We reviewed 31 eligible studies, and observed variations in ABR construct definition and measurement, study design, and analytic approach. The most common ABR measures were indicators of socioeconomic status (SES) (e.g., income, education, summary measures of several SES indicators or composite SES). We observed positive associations between breast cancer incidence and urbanization (Pooled RR for urban vs. rural: 1.09. 95% CI: 1.01, 1.19), ABR income (Pooled RR for highest vs. lowest ABR income: 1.17, 95% CI: 1.15, 1.19) and ABR composite SES (Pooled RR for highest vs. lowest ABR composite SES: 1.25, 95% CI: 1.08, 1.44). We did not observe consistent associations between any ABR measures and breast cancer mortality.

Conclusions:
The findings suggest modest positive associations between urbanization and residential area socioeconomic environment and breast cancer incidence. Further studies should address conceptual and methodological gaps in the current publications to enable inference regarding the influence of the residential environment on breast cancer.

Keywords:

Breast cancer epidemiology Residential environment Socio-economic status Mortality Urbanization
Smooth and non-smooth traveling wave solutions of some generalized Camassa-Holm equations
Creators: name: Rehman, T.
name: Gambino, G.
name: Choudhury, S. Roy
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: In this paper we employ two recent analytical approaches to investigate the possible classes of traveling wave solutions of some members of a recently-derived integrable family of generalized Camassa-Holm (GCH) equations. A recent, novel application of phase-plane analysis is employed to analyze the singular traveling wave equations of three of the GCH NLPDEs, i.e. the possible non-smooth peakon and cuspon solutions. One of the considered GCH equations supports both solitary (peakon) and periodic (cuspon) cusp waves in different parameter regimes. The second equation does not support singular traveling waves and the last one supports four-segmented, non-smooth $M$-wave solutions. Moreover, smooth traveling waves of the three GCH equations are considered. Here, we use a recent technique to derive convergent multi-infinite series solutions for the homoclinic orbits of their traveling-wave equations, corresponding to pulse (kink or shock) solutions respectively of the original PDEs. We perform many numerical tests in different parameter regime to pinpoint real saddle equilibrium points of the corresponding GCH equations, as well as ensure simultaneous convergence and continuity of the multi-infinite series solutions for the homoclinic orbits anchored by these saddle points. Unlike the majority of unaccelerated convergent series, high accuracy is attained with relatively few terms. We also show the traveling wave nature of these pulse and front solutions to the GCH NLPDEs.
Adapting an evidence-based HIV behavioral intervention for South African couples
Creators: name: Wechsberg, Wendee M.
name: El-Bassel, Nabila
name: Carney, Tara
name: Browne, Felicia A.
name: Myers, Bronwyn
name: Zule, William A.
Publisher: name: Columbia University
Year: 2015
Subjects: HIV-positive persons--Sexual behavior
Couples--Health and hygiene
HIV infections—Prevention
Public health

description: Background:
In South Africa, heterosexual couples are at risk for HIV infection and transmission through substance use, gender-based violence and traditional gender roles, and sex risk behaviors such as having multiple partners and unsafe sex.

Methods:
To address these interconnected HIV risks among heterosexual couples, we used the ADAPT framework to modify an existing, efficacious women’s HIV prevention intervention (the Western Cape Women’s Health CoOp) to include components of an evidence-based couple’s intervention from the United States (Project Connect) and components from the Men as Partners program that has been used successfully in South Africa. We conducted focus groups with men, women and couples, and obtained feedback from a long-standing Community Collaborative Board (CCB) to guide the synthesis of elements of these three interventions into a new intervention. We then piloted the adapted intervention for feasibility and acceptability.

Results:
The new intervention is called the Couples’ Health CoOp. This intervention targets men who use alcohol and other drugs and engage in unprotected sex, and their main female sex partners. The intervention addresses substance use, sex risk, HIV and other sexually transmitted infections, gender roles, gender-based violence, communication skills, and goal-setting activities to increase sexy (eroticize) safe-sex behaviors. The Couples’ Health CoOp also includes “voices” from the focus group members to ground the intervention in the experiences of these at-risk couples. In addition, it utilizes a participant handbook that reiterates workshop content and includes homework assignments for couples to complete together to increase problem-solving skills within their relationship, and to improve their sexual relationship and help sustain HIV risk-reduction strategies. All of these adaptations were based on participants’ suggestions made during formative work and pilot testing.

Conclusions:
The Couples’ Health CoOp is a couple-based HIV prevention intervention that targets alcohol and other drug use to reduce sexual risk, reduce gender-based violence and offer alternatives for conflict resolution, promote healthy relationships, and modify traditional gender roles in South Africa.Keywords:

HIV Heterosexual couples Intervention adaptation Substance abuse Gender-based violence Sex risk behaviors South Africa
title: Knechte Gottes als Lieblinge des Himmels; 1779
title: Eine Gast- und Vesperpredigt gehalten zu Straßburg in der Stiftskirche zu St. Thomä am Tage aller Heiligen, über die gewöhnliche Epistel aus der Offenb. Johannis im VII Cap. v. 2. 3.
titleType: Subtitle
Creators: name: Lobstein, Johann Michael
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2015

description: In Fraktur
Detect adverse drug reactions for drug Pioglitazone
Creators: name: Liu, Yihui
name: Aickelin, Uwe
Publisher: name: arXiv
Year: 2013
Subjects: subject: Computational Engineering, Finance, and Science (cs.CE)
subject: FOS: Computer and information sciences

description: In this study we propose a novel method to successfully detect the ADRs using feature matrix and feature selection. A feature matrix, which characterizes the medical events before patients take drugs or after patients take drugs, is created from THIN database. The feature selection method of Student's t-test is used to detect the significant features from thousands of medical events. The significant ADRs, which are corresponding to significant features, are detected. Experiments are performed on the drug Pioglitazone. Compared to other computerized methods, our proposed method achieves good performance.
description: IEEE 11th International Conference on Signal Processing (ICSP), 1654-1658, 2012
A Proof System with Names for Modal Mu-calculus
Creators: name: Stirling, Colin
Publisher: name: arXiv
Year: 2013
Subjects: subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences

description: Fixpoints are an important ingredient in semantics, abstract interpretation and program logics. Their addition to a logic can add considerable expressive power. One general issue is how to define proof systems for such logics. Here we examine proof systems for modal logic with fixpoints. We present a tableau proof system for checking validity of formulas which uses names to keep track of unfoldings of fixpoint variables as devised by Jungteerapanich.
description: In Proceedings Festschrift for Dave Schmidt, arXiv:1309.4557
PAX7 is required for patterning the esophageal musculature
Creators: name: Chihara, Daisuke
name: Romer, Anthony I.
name: Bentzinger, C. Florian
name: Rudnicki, Michael A.
name: Krauss, Robert S.
Publisher: name: Columbia University
Year: 2015
Subjects: Genetic transcription--Regulation
Stem cells
Esophagus--Muscles
Biochemistry
Biomechanics

description: Background
The mammalian esophageal musculature is unique in that it makes a transition from smooth to skeletal muscle, with most of this process occurring after birth. In order to better understand the mechanisms that control esophageal musculature development, we investigated the roles in this process of the paired box transcription factor, PAX7, a principal regulator of skeletal myogenic progenitor cells. Previous studies showed that Pax7 is important for determining the esophageal muscle composition.

Results
We characterized the postnatal development of the esophageal musculature in Pax7 −/− mice by analyzing morphology, muscle composition, and the expression of markers of myogenesis, cell proliferation, and apoptosis. Pax7 −/− mice displayed megaesophagus with a severe defect in the postnatal developmental process whereby esophageal smooth muscle is replaced by skeletal muscle. Pax7 −/− esophagi have substantially reduced skeletal muscle, most likely due to diminished proliferation and premature differentiation of skeletal muscle precursor cells. This impaired the proximal-to-distal progression of skeletal myogenesis and indirectly affected the patterning of the smooth muscle-containing portion of the esophageal musculature.

Conclusions
Postnatal patterning of the esophageal musculature appears to require robust, PAX7-dependent cell proliferation to drive the proximal-to-distal progression of skeletal myogenesis. This process in turn influences distal smooth muscle morphogenesis and development of the mature pattern of the esophageal musculature.
Searching for Elko dark matter spinors at the CERN LHC
Creators: name: Alves, Alexandre
name: de Campos, Fernando
name: Dias, Marco
name: da Silva, Julio M. Hoff
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The aim of this work is to explore the possibility to discover a fermionic field with mass dimension one, the Elko field, in the Large Hadron Collider (LHC). Due to its mass dimension, an Elko can only interact either with Standard Model (SM) spinors and gauge fields at 1-loop order or at tree level through a quartic interaction with the Higgs field. In this Higgs portal scenario, the Elko is a viable candidate to a dark matter constituent which has been shown to be compatible with relic abundance measurements from WMAP and direct dark matter--nucleon searches. We propose a search strategy for this dark matter candidate in the channel $pp \rightarrow l^+ l^- + \not\!\! E_T$ at the $\sqrt{s}=14$ TeV LHC. We show the LHC potential to discover the Elko considering a triple Higgs-Elko coupling as small as $\sim 0.5$ after 1 pb$^{-1}$ of integrated luminosity. Some phenomenological consequences of this new particle and its collider signatures are also discussed.
description: 7 pages, 3 figures
On Quantifying Qualitative Geospatial Data: A Probabilistic Approach
Creators: name: Skoumas, Georgios
name: Pfoser, Dieter
name: Kyrillidis, Anastasios
Publisher: name: arXiv
Year: 2013
Subjects: subject: Databases (cs.DB)
subject: FOS: Computer and information sciences
subject: H.2.8
subject: 62-07

description: Living in the era of data deluge, we have witnessed a web content explosion, largely due to the massive availability of User-Generated Content (UGC). In this work, we specifically consider the problem of geospatial information extraction and representation, where one can exploit diverse sources of information (such as image and audio data, text data, etc), going beyond traditional volunteered geographic information. Our ambition is to include available narrative information in an effort to better explain geospatial relationships: with spatial reasoning being a basic form of human cognition, narratives expressing such experiences typically contain qualitative spatial data, i.e., spatial objects and spatial relationships. To this end, we formulate a quantitative approach for the representation of qualitative spatial relations extracted from UGC in the form of texts. The proposed method quantifies such relations based on multiple text observations. Such observations provide distance and orientation features which are utilized by a greedy Expectation Maximization-based (EM) algorithm to infer a probability distribution over predefined spatial relationships; the latter represent the quantified relationships under user-defined probabilistic assumptions. We evaluate the applicability and quality of the proposed approach using real UGC data originating from an actual travel blog text corpus. To verify the quality of the result, we generate grid-based maps visualizing the spatial extent of the various relations.
De novo transcriptome reconstruction and annotation of the Egyptian rousette bat
Creators: name: Lee, Albert Kim
name: Kulcsar, Kirsten A.
name: Elliott, Oliver T.
name: Khiabanian, Hossein
name: Nagle, Elyse R.
name: Jones, Megan E.B.
name: Amman, Brian R.
name: Sanchez-Lockhart, Mariano
name: Towner, Jonathan S.
name: Palacios, Gustavo
name: Rabadan, Raul
Publisher: name: Columbia University
Year: 2015
Subjects: Marburg virus disease
Virus diseases--Pathogenesis
Host-virus relationships
Morphology
Virology

description: Background
The Egyptian Rousette bat (Rousettus aegyptiacus), a common fruit bat species found throughout Africa and the Middle East, was recently identified as a natural reservoir host of Marburg virus. With Ebola virus, Marburg virus is a member of the family Filoviridae that causes severe hemorrhagic fever disease in humans and nonhuman primates, but results in little to no pathological consequences in bats. Understanding host-pathogen interactions within reservoir host species and how it differs from hosts that experience severe disease is an important aspect of evaluating viral pathogenesis and developing novel therapeutics and methods of prevention.

Results
Progress in studying bat reservoir host responses to virus infection is hampered by the lack of host-specific reagents required for immunological studies. In order to establish a basis for the design of reagents, we sequenced, assembled, and annotated the R. aegyptiacus transcriptome. We performed de novo transcriptome assembly using deep RNA sequencing data from 11 distinct tissues from one male and one female bat. We observed high similarity between this transcriptome and those available from other bat species. Gene expression analysis demonstrated clustering of expression profiles by tissue, where we also identified enrichment of tissue-specific gene ontology terms. In addition, we identified and experimentally validated the expression of novel coding transcripts that may be specific to this species.

Conclusion
We comprehensively characterized the R. aegyptiacus transcriptome de novo. This transcriptome will be an important resource for understanding bat immunology, physiology, disease pathogenesis, and virus transmission.
On the Suitable Domain for SVM Training in Image Coding
Creators: name: Camps-Valls, Gustavo
name: Gutiérrez, Juan
name: Gómez-Pérez, Gabriel
name: Malo, Jesús
Publisher: name: arXiv
Year: 2013
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: Conventional SVM-based image coding methods are founded on independently restricting the distortion in every image coefficient at some particular image representation. Geometrically, this implies allowing arbitrary signal distortions in an $n$-dimensional rectangle defined by the $\varepsilon$-insensitivity zone in each dimension of the selected image representation domain. Unfortunately, not every image representation domain is well-suited for such a simple, scalar-wise, approach because statistical and/or perceptual interactions between the coefficients may exist. These interactions imply that scalar approaches may induce distortions that do not follow the image statistics and/or are perceptually annoying. Taking into account these relations would imply using non-rectangular $\varepsilon$-insensitivity regions (allowing coupled distortions in different coefficients), which is beyond the conventional SVM formulation. In this paper, we report a condition on the suitable domain for developing efficient SVM image coding schemes. We analytically demonstrate that no linear domain fulfills this condition because of the statistical and perceptual inter-coefficient relations that exist in these domains. This theoretical result is experimentally confirmed by comparing SVM learning in previously reported linear domains and in a recently proposed non-linear perceptual domain that simultaneously reduces the statistical and perceptual relations (so it is closer to fulfilling the proposed condition). These results highlight the relevance of an appropriate choice of the image representation before SVM learning.
British Columbia Legislative Assembly sessional clipping book (1891-01)
Creators: name: :Unav
Publisher: name: University of Victoria Libraries
Year: 2022
Subjects: subject: Law
valueUri: http://id.worldcat.org/fast/993678
subject: FOS: Law
subject: British Columbia. Legislative Assembly
valueUri: http://id.worldcat.org/fast/600765
subject: Politics and government
valueUri: http://id.worldcat.org/fast/1919741

description: These Sessional Clippings books cover the period 1891 to 1972, and include newspaper accounts written by various legislative reporters who covered debates occurring in the British Columbia Legislative Assembly. Transcripts of debates of the Legislative Assembly (Hansard) were not published in B.C. until 1970; hence these "Sessional Clipping Books" augment the "Journals", the record of daily proceedings of the Legislative Assembly. Selected clippings from various newspapers including the Vancouver Sun, the Vancouver Province, the Colonist, and the Times newspapers, relating to the newspaper reports concerning activities of the Legislature. The original sessional clippings books comprise 351 ledger size print volumes, held at the Legislative Library in Victoria BC. The print volumes were microfilmed onto 26 reels in 1977 under a Tri University Libraries (TRIUL) project by Precision Micrographic Services (Vancouver, B.C.), with the permission of the Legislative Library, Victoria, British Columbia. This digital collection was created by scanning the 26 microfilm reels.
Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice
Creators: name: Kim-Muller, Ja Young
name: Fan, Jason Chen
name: R. Kim, Young Jung
name: Lee, Seung-Ah
name: Ishida, Emi
name: Blaner, William S.
name: Accili, Domenico
Publisher: name: Columbia University
Year: 2016
Subjects: Pancreatic beta cells
Diabetes--Etiology
Aldehyde dehydrogenase
Cytology

description: Insulin-producing β cells become dedifferentiated during diabetes progression. An impaired ability to select substrates for oxidative phosphorylation, or metabolic inflexibility, initiates progression from β-cell dysfunction to β-cell dedifferentiation. The identification of pathways involved in dedifferentiation may provide clues to its reversal. Here we isolate and functionally characterize failing β cells from various experimental models of diabetes and report a striking enrichment in the expression of aldehyde dehydrogenase 1 isoform A3 (ALDH+) as β cells become dedifferentiated. Flow-sorted ALDH+ islet cells demonstrate impaired glucose-induced insulin secretion, are depleted of Foxo1 and MafA, and include a Neurogenin3-positive subset. RNA sequencing analysis demonstrates that ALDH+ cells are characterized by: (i) impaired oxidative phosphorylation and mitochondrial complex I, IV and V; (ii) activated RICTOR; and (iii) progenitor cell markers. We propose that impaired mitochondrial function marks the progression from metabolic inflexibility to dedifferentiation in the natural history of β-cell failure.
Microcavia niata
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Caviidae
Microcavia
Microcavia niata

description: Microcavia niata (Thomas, 1898). Ann. Mag. Nat. Hist., ser. 7, 1:282. TYPE LOCALITY: Bolivia, Oruro Dept., Monte Sajama, 4000 m. DISTRIBUTION: S.W. Bolivia in the high Andes. ISIS NUMBER: 5301410019004002001.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Rodentia (Part 6), pp. 560-594 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 574, DOI: 10.5281/zenodo.7353039
Notes on counter-orbiting globular clusters in the Milky Way
Creators: name: Yankelevich, Victoria
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: It is argued that Galactic globular clusters rotating retrograde may originate from prograde globular clusters that change their angular momenturm due to gravitational perturbations from the Magellanic Cloud galaxies. It is shown that those galactic globular clusters with orbits near the Lagrangiane point of the system "Milky Way - Maggellanic Clouds" can change the sign of their angular momentum in few Gyr time scale.
description: 9 pages, 6 figures
Proteomic assessment of a cell model of spinal muscular atrophy
Creators: name: Wu, Chia-Yen
name: Whye, Dosh
name: Glazewski, Lisa
name: Choe, Leila
name: Kerr, Douglas
name: Lee, Kelvin H.
name: Mason, Robert W.
name: Wang, Wenlan
Publisher: name: Columbia University
Year: 2011
Subjects: Neuromuscular diseases
Proteins--Analysis
Spinal muscular atrophy
Morphology
Aging

description: Background
Deletion or mutation(s) of the survival motor neuron 1 (SMN1) gene causes spinal muscular atrophy (SMA), a neuromuscular disease characterized by spinal motor neuron death and muscle paralysis. Complete loss of the SMN protein is embryonically lethal, yet reduced levels of this protein result in selective death of motor neurons. Why motor neurons are specifically targeted by SMN deficiency remains to be determined. In this study, embryonic stem (ES) cells derived from a severe SMA mouse model were differentiated into motor neurons in vitro by addition of retinoic acid and sonic hedgehog agonist. Proteomic and western blot analyses were used to probe protein expression alterations in this cell-culture model of SMA that could be relevant to the disease.

Results
When ES cells were primed with Noggin/fibroblast growth factors (bFGF and FGF-8) in a more robust neural differentiation medium for 2 days before differentiation induction, the efficiency of in vitro motor neuron differentiation was improved from ~25% to ~50%. The differentiated ES cells expressed a pan-neuronal marker (neurofilament) and motor neuron markers (Hb9, Islet-1, and ChAT). Even though SMN-deficient ES cells had marked reduced levels of SMN (~20% of that in control ES cells), the morphology and differentiation efficiency for these cells are comparable to those for control samples. However, proteomics in conjunction with western blot analyses revealed 6 down-regulated and 14 up-regulated proteins with most of them involved in energy metabolism, cell stress-response, protein degradation, and cytoskeleton stability. Some of these activated cellular pathways showed specificity for either undifferentiated or differentiated cells. Increased p21 protein expression indicated that SMA ES cells were responding to cellular stress. Up-regulation of p21 was confirmed in spinal cord tissues from the same SMA mouse model from which the ES cells were derived.

Conclusion
SMN-deficient ES cells provide a cell-culture model for SMA. SMN deficiency activates cellular stress pathways, causing a dysregulation of energy metabolism, protein degradation, and cytoskeleton stability.
Microcavia shiptoni
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Caviidae
Microcavia
Microcavia shiptoni

description: Microcavia shiptoni (Thomas, 1925). Ann. Mag. Nat. Hist., ser. 9, 15:419. TYPE LOCALITY: Argentina, Catamarca Prov., Laguna Blanca, 3400 m. DISTRIBUTION: N.W. Argentina. ISIS NUMBER: 5301410019004003001.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Rodentia (Part 6), pp. 560-594 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 574, DOI: 10.5281/zenodo.7353039
Concomitant Socioeconomic, Behavioral, and Biological Factors Associated with the Disproportionate HIV Infection Burden among Black Men Who Have Sex with Men in 6 U.S. Cities
Creators: name: Mayer, Kenneth H.
name: Wang, Lei
name: Koblin, Beryl
name: Mannheimer, Sharon B.
name: Magnus, Manya
name: Del Rio, Carlos
name: Buchbinder, Susan
name: Wilton, Leo
name: Cummings, Vanessa
name: Watson, Christopher C.
name: Piwowar-Manning, Estelle
name: Gaydos, Charlotte
name: Eshleman, Susan H.
name: Clarke, William
name: Liu, Ting-Yuan
name: Griffith, Samuel
name: Mao, Cherry
name: Wheeler, Darrell
name: HPTN061 Protocol Team
Publisher: name: Columbia University
Year: 2014
Subjects: Gay men, Black
HIV infections--Epidemiology
HIV infections--Diagnosis
HIV-positive men
Epidemiology

description: Background

American Black men who have sex with men (MSM) are disproportionately affected by HIV, but the factors associated with this concentrated epidemic are not fully understood.

Methods

Black MSM were enrolled in 6 US cities to evaluate a multi-component prevention intervention, with the current analysis focusing on the correlates of being newly diagnosed with HIV compared to being HIV-uninfected or previously diagnosed with HIV.

Results

HPTN 061 enrolled 1553 Black MSM whose median age was 40; 30% self-identified exclusively as gay or homosexual, 29% exclusively as bisexual, and 3% as transgender. About 1/6th (16.2%) were previously diagnosed with HIV (PD); of 1263 participants without a prior HIV diagnosis 7.6% were newly diagnosed (ND). Compared to PD, ND Black MSM were younger (p < 0.001); less likely to be living with a primary partner (p < 0.001); more likely to be diagnosed with syphilis (p < 0.001), rectal gonorrhea (p = 0.011) or chlamydia (p = 0.020). Compared to HIV-uninfected Black MSM, ND were more likely to report unprotected receptive anal intercourse (URAI) with a male partner in the last 6 months (p < 0.001); and to be diagnosed with syphilis (p < 0.001), rectal gonorrhea (p = 0.004), and urethral (p = 0.025) or rectal chlamydia (p < 0.001). They were less likely to report female (p = 0.002) or transgender partners (p = 0.018). Multivariate logistic regression analyses found that ND Black MSM were significantly more likely than HIV-uninfected peers to be unemployed; have STIs, and engage in URAI. Almost half the men in each group were poor, had depressive symptoms, and expressed internalized homophobia.

Conclusions

ND HIV-infected Black MSM were more likely to be unemployed, have bacterial STIs and engage in URAI than other Black MSM. Culturally-tailored programs that address economic disenfranchisement, increase engagement in care, screen for STIs, in conjunction with safer sex prevention interventions, may help to decrease further transmission in this heavily affected community.
A Comparison of Well-Quasi Orders on Trees
Creators: name: Mogensen, Torben Æ.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Programming Languages (cs.PL)
subject: Computational Complexity (cs.CC)
subject: Data Structures and Algorithms (cs.DS)
subject: FOS: Computer and information sciences
subject: E.1; F.2.2; F.3.2

description: Well-quasi orders such as homeomorphic embedding are commonly used to ensure termination of program analysis and program transformation, in particular supercompilation. We compare eight well-quasi orders on how discriminative they are and their computational complexity. The studied well-quasi orders comprise two very simple examples, two examples from literature on supercompilation and four new proposed by the author. We also discuss combining several well-quasi orders to get well-quasi orders of higher discriminative power. This adds 19 more well-quasi orders to the list.
description: In Proceedings Festschrift for Dave Schmidt, arXiv:1309.4557
British Columbia Legislative Assembly sessional clipping book (1892-01)
Creators: name: :Unav
Publisher: name: University of Victoria Libraries
Year: 2022
Subjects: subject: Law
valueUri: http://id.worldcat.org/fast/993678
subject: FOS: Law
subject: Politics and government
valueUri: http://id.worldcat.org/fast/1919741
subject: British Columbia. Legislative Assembly
valueUri: http://id.worldcat.org/fast/600765

description: These Sessional Clippings books cover the period 1891 to 1972, and include newspaper accounts written by various legislative reporters who covered debates occurring in the British Columbia Legislative Assembly. Transcripts of debates of the Legislative Assembly (Hansard) were not published in B.C. until 1970; hence these "Sessional Clipping Books" augment the "Journals", the record of daily proceedings of the Legislative Assembly. Selected clippings from various newspapers including the Vancouver Sun, the Vancouver Province, the Colonist, and the Times newspapers, relating to the newspaper reports concerning activities of the Legislature. The original sessional clippings books comprise 351 ledger size print volumes, held at the Legislative Library in Victoria BC. The print volumes were microfilmed onto 26 reels in 1977 under a Tri University Libraries (TRIUL) project by Precision Micrographic Services (Vancouver, B.C.), with the permission of the Legislative Library, Victoria, British Columbia. This digital collection was created by scanning the 26 microfilm reels.
Hydrochaeridae Gray 1825
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Hydrochaeridae

description: Family Hydrochaeridae REVIEWED BY: J. P. Jorgenson (JPJ); M. A. Mares (MAM); T. Pearson (TP); C. A. Woods (CAW). ISIS NUMBER: 5301410020000000000.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Rodentia (Part 6), pp. 560-594 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 575, DOI: 10.5281/zenodo.7353039
Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages
Creators: name: Doobin, David J.
name: Kemal, Shahrnaz
name: Dantas, Tiago J.
name: Vallee, Richard B.
Publisher: name: Columbia University
Year: 2016
Subjects: subject: Stem cells
subject: Electroporation
subject: Microcephaly
subject: Neurosciences
subject: FOS: Clinical medicine

description: Microcephaly is a cortical malformation disorder characterized by an abnormally small brain. Recent studies have revealed severe cases of microcephaly resulting from human mutations in the NDE1 gene, which is involved in the regulation of cytoplasmic dynein. Here using in utero electroporation of NDE1 short hairpin RNA (shRNA) in embryonic rat brains, we observe cell cycle arrest of proliferating neural progenitors at three distinct stages: during apical interkinetic nuclear migration, at the G2-to-M transition and in regulation of primary cilia at the G1-to-S transition. RNAi against the NDE1 paralogue NDEL1 has no such effects. However, NDEL1 overexpression can functionally compensate for NDE1, except at the G2-to-M transition, revealing a unique NDE1 role. In contrast, NDE1 and NDEL1 RNAi have comparable effects on postmitotic neuronal migration. These results reveal that the severity of NDE1-associated microcephaly results not from defects in mitosis, but rather the inability of neural progenitors to ever reach this stage.
Volume-wise destruction of the antiferromagnetic Mott insulating state through quantum tuning
Creators: name: Frandsen, Benjamin A.
name: Liu, Lian
name: Cheung, Sky Chance
name: Khasanov, Rustem
name: Guguchia, Zurab
name: Morenzoni, Elvezio
name: Munsie, Timothy J. S.
name: Hallas, Alannah M.
name: Cai, Yipeng
name: Wilson, Murray N.
name: Luke, Graeme M.
name: Chen, Bijuan
name: Li, Wenmin
name: Ding, Cui
name: Jin, Changqing
name: Guo, Shengli
name: Ning, Fanlong
name: Ito, Takashi U.
name: Higemoto, Wataru
name: Billinge, Simon J. L.
name: Sakamoto, Shoya
name: Fujimori, Atsushi
name: Murakami, Taito
name: Kageyama, Hiroshi
name: Alonso, Jose Antonio
name: Kotliar, Gabriel
name: Imada, Masatoshi
name: Uemura, Yasutomo J.
Publisher: name: Columbia University
Year: 2016
Subjects: Muon spin rotation
Energy levels (Quantum mechanics)
Rare earth metals--Magnetic properties
Quantum theory

description: RENiO3 (RE=rare-earth element) and V2O3 are archetypal Mott insulator systems. When tuned by chemical substitution (RENiO3) or pressure (V2O3), they exhibit a quantum phase transition (QPT) between an antiferromagnetic Mott insulating state and a paramagnetic metallic state. Because novel physics often appears near a Mott QPT, the details of this transition, such as whether it is first or second order, are important. Here, we demonstrate through muon spin relaxation/rotation (μSR) experiments that the QPT in RENiO3 and V2O3 is first order: the magnetically ordered volume fraction decreases to zero at the QPT, resulting in a broad region of intrinsic phase separation, while the ordered magnetic moment retains its full value until it is suddenly destroyed at the QPT. These findings bring to light a surprising universality of the pressure-driven Mott transition, revealing the importance of phase separation and calling for further investigation into the nature of quantum fluctuations underlying the transition.
Hydrochaeris Brunnich 1772
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Hydrochaeridae
Hydrochaeris

description: Hydrochaeris Brunnich, 1772. Zool. Fundamenta, p. 44. COMMENT: Husson, 1978:457, discussed the spelling of the generic name. ISIS NUMBER: 5301410020001000000.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Rodentia (Part 6), pp. 560-594 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 575, DOI: 10.5281/zenodo.7353039
description: {"references": ["Husson, A. M. 1978. The mammals of Suriname. E. J. Brill, Leiden, 569 pp., 160 pls."]}