cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A pragmatic reconstruction of M.A.K. Halliday’s systemic functional grammar
Creators: name: Wylie, Peter K.
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: M.A.K. Halliday’s metafunctional functionalism, which forms the basis for the semantics of his grammar, is based upon a revision of Bühler’s triadic functions of language. However, the more philosophical, classical American branch of the pragmatic tradition developed a likewise triadic understanding of experience, which also differs from Bühler’s. Whitehead’s pragmatic metaphysics provides the most comprehensive example of such a non-reductive philosophical system, crowned by an aesthetically-based general theory of value. These different functional trajectories suggest the possibility of reconstructing Halliday’s central functional notions, including his three metafunctions and subject notions (Theme, Subject and Actor), thereby radicalizing existing critiques advanced by McGregor, Martin, Bateman and others. On this view, the organic unity of language is based upon its expressive compositionality, grounded in the compositionality of value rather than independent metafunctions. An emphasis on action, motivated by the expression and realization of value, means that the underlying conceptions of language also differ. Although Halliday’s grammar is amongst the more comprehensive, functional linguistic theories, his functionalism is based upon the system network formalism. On this pragmatic view, the contents conveyed by a grammar are not abstract, general categories as Halliday holds, but rather valuations intrinsic to the organization of language itself. These function to organize the now grammatically central activity of reference, understood not representationally, as language transcendent, but immanently. The content of the grammar, now understood as composed of indexicals or shifters, generalized beyond words to all forms of grammatical expression, is, then, essentially reflexive, relative and variable. Indeed, not just Halliday’s textual metafunction, but the whole of the grammar provides language users with the means to jointly coordinate their linguistic activities by varying the valuations that form the organizational basis for their discourse.
A Modular Regularized Variational Multiscale Proper Orthogonal Decomposition for Incompressible Flows
Creators: name: Eroglu, Fatma G.
name: Kaya, Songul
name: Rebholz, Leo G.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: In this paper, we propose, analyze and test a post-processing implementation of a projection-based variational multiscale (VMS) method with proper orthogonal decomposition (POD) for the incompressible Navier-Stokes equations. The projection-based VMS stabilization is added as a separate post-processing step to the standard POD approximation, and since the stabilization step is completely decoupled, the method can easily be incorporated into existing codes, and stabilization parameters can be tuned independent from the time evolution step. We present a theoretical analysis of the method, and give results for several numerical tests on benchmark problems which both illustrate the theory and show the proposed method's effectiveness.
Additional file 1: Table S1. of Low serum sodium concentration is a prognostic factor related to current blood glucose level in stable hemodialysis patients: an observational study
Creators: name: Nagai, Kojiro
name: Ueda, Sayo
name: Tsuchida, Kenji
name: Doi, Toshio
name: Minakuchi, Jun
Publisher: name: figshare
Year: 2017
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Hematology

description: Demographic and clinical characteristics of stable hemodialysis patients analyzed in age-stratified analysis (PDF 142Â kb)
Additional file 6: of Insulin-like growth factor receptor and sphingosine kinase are prognostic and therapeutic targets in breast cancer
Creators: name: Ochnik, Aleksandra
name: Baxter, Robert
Publisher: name: figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Plant Biology
subject: 60506 Virology

description: OSI-906 inhibits p-IGF1R and IGF1R signaling factors in breast cancer cell-lines. 3 × 105 ER-positive A. MCF7 and ER-negative B. HCC-1806 breast cancer cells were plated per well of a 6-well plate and cultured for 24 h and subsequently treated with the dual IGF1R/InsR dual tyrosine kinase inhibitor (OSI-906; 0.1, 0.4 and 1.6 μM) and/or SphK1 inhibitor (SKI-II; 4 μM) for 24 h. Protein lysates were collected and 20 μg of protein was used for immunoblot analysis to measure changes to IGF1R signaling (i.e. AKT and eIF4E-BP1 (protein translation)) and SphK1 steady-state protein expression levels. B-actin was used as a loading control. Abbreviations: Hyper-P = hyper-phosphorylation and Hypo-P = hypophosphorylated. (DOCX 255 kb)
Population background exploration and genetic distribution analysis Pakistan Hazara via 23 autosomal STRs
Creators: name: Chen, Pengyu
name: Adnan, Atif
name: Rakha, Allah
name: Wang, Mengge
name: Zou, Xing
name: Mo, Xiaodan
name: He, Guanglin
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Computational Biology

description: Background: Short tandem repeats (STRs) have gained considerable attention in family searches (Y-chromosomal STRs), complex paternity identification (X-chromosomal STRs), routine forensic personal identification (autosomal STRs) and population genetics. Aim: To explore the forensic characteristics of 23 autosomal STRs included in the Huaxia Platinum system in the South Pakistan Hazara population and investigate the genetic similarities and differences between Hazara and 54 worldwide reference populations. Subjects and methods: Variation in the 23-autosomal STRs detected by the Huaxia Platinum system was first investigated and reported in a sample 261 Quetta Hazara in Balochistan Province, Southwest Pakistan. Results: The combined power of discrimination is 0.999999999999999999999999999 and combined power of exclusion is 0.99999999989596 in Quetta Hazara. Comprehensive population comparisons between Hazara and another 13 Eurasian populations based on genotype data, as well as between Hazara and 54 worldwide populations based on the allele frequency distribution, were conducted. Multidimensional scaling plots, principal components analysis, and neighboring-joining phylogenetic trees consistently demonstrated that Pakistan Hazara harbour close affinities with neighbouring Turkic-speaking populations. Model-based genetic structure analysis further suggests that Quetta Hazara derives about half its ancestry directly from the East Asians. Conclusion: 25 forensic-related markers included in the Huaxia Platinum system can be used for forensic practice in the Central Asia Hazara population. Quetta Hazara has a close genetic relationship with the Turkic-speaking populations Uyghur and Kazakh. Further whole-genome sequencing of Hazara needs to be conducted to validate the observed genetic structure and reconstruct the fine-scale population history of Hazara.
Highly specific host-pathogen interactions influence Metarhizium brunneum blastospore virulence against Culex quinquefasciatus larvae
Creators: name: Alkhaibari, Abeer M.
name: Lord, Alex M.
name: Maffeis, Thierry
name: Bull, James C.
name: Olivares, Fabio L.
name: Samuels, Richard I.
name: Butt, Tariq M.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Evolutionary Biology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology
subject: Computational Biology

description: Entomopathogenic fungi are potential biological control agents of mosquitoes. Our group observed that not all mosquitoes were equally susceptible to fungal infection and observed significant differences in virulence of different spore types. Conidiospores and blastospores were tested against Culex quinquefasciatus larvae. Blastospores are normally considered more virulent than conidia as they form germ tubes and penetrate the host integument more rapidly than conidia. However, when tested against Cx. quinquefasciatus, blastospores were less virulent than conidia. This host-fungus interaction was studied by optical, electron and atomic force microscopy (AFM). Furthermore, host immune responses and specific gene expression were investigated. Metarhizium brunneum (formerly M. anisopliae) ARSEF 4556 blastospores did not readily adhere to Culex larval integument and the main route of infection was through the gut. Adhesion forces between blastospores and Culex cuticle were significantly lower than for other insects. Larvae challenged with blastospores showed enhanced immune responses, with increased levels of phenoloxidase, glutathione-S-transferase, esterase, superoxide dismutase and lipid peroxidase activity. Interestingly, M. brunneum pathogenicity/stress-related genes were all down-regulated in blastospores exposed to Culex. Conversely, when conidia were exposed to Culex, the pathogenicity genes involved in adhesion or cuticle degradation were up-regulated. Delayed host mortality following blastospore infection of Culex was probably due to lower adhesion rates of blastospores to the cuticle and enhanced host immune responses deployed to counter infection. The results here show that subtle differences in host-pathogen interactions can be responsible for significant changes in virulence when comparing mosquito species, having important consequences for biological control strategies and the understanding of pathogenicity processes.
Stereotactic Body Radiation Therapy for the Curative Treatment of Prostate Cancer in Ultralarge (≥100 cc) Glands
Creators: name: Hurwitz, Joshua C.
name: Haas, Jonathan
name: Mendez, Christopher
name: Sanchez, Astrid
name: Santos, Vianca F.
name: Akerman, Meredith
name: Carpenter, Todd
name: Tam, Moses
name: Katz, Aaron
name: Corcoran, Anthony
name: Mahadevan, Anand
name: Taneja, Samir S.
name: Lepor, Herbert
name: Lischalk, Jonathan W.
Publisher: name: PRIME
Year: 2024
Subjects: classificationCode: 320222
subject: Radiology and organ imaging
classificationCode: 320214
subject: Nephrology and urology

description: AbstractPurpose: Historically, toxicity concerns have existed in patients with large prostate glands treated with radiation therapy, particularly brachytherapy. There are questions whether this risk extends to stereotactic body radiation therapy (SBRT). In this retrospective review, we examine clinical outcomes of patients with prostate glands ≥100 cc treated curatively with SBRT.Methods and materials: We retrospectively analyzed a large institutional database to identify patients with histologically confirmed localized prostate cancer in glands ≥100 cc, who were treated with definitive-robotic SBRT. Prostate volume (PV) was determined by treatment planning magnetic resonance imaging. Toxicity was measured using Common Terminology Criteria for Adverse Events, version 5.0. Many patients received the Expanded Prostate Cancer Index Composite Quality of Life questionnaires. Minimum follow-up (FU) was 2 years.Results: Seventy-one patients were identified with PV ≥100 cc. Most had grade group (GG) 1 or 2 (41% and 37%, respectively) disease. All patients received a total dose of 3500 to 3625 cGy in 5 fractions. A minority (27%) received androgen deprivation therapy (ADT), which was used for gland size downsizing in only 10% of cases. Nearly half (45%) were taking GU medications for urinary dysfunction before RT. Median toxicity FU was 4.0 years. Two-year rates of grade 1+ genitourinary (GU), grade 1+ gastrointestinal (GI), and grade 2+ GU toxicity were 43.5%, 15.9%, and 30.4%, respectively. Total grade 3 GU toxicities were very limited (2.8%). There were no grade 3 GI toxicities. On logistic regression analysis, pretreatment use of GU medications was significantly associated with increased rate of grade 2+ GU toxicity (odds ratio, 3.19; P = .024). Furthermore, PV (analyzed as a continuous variable) did not have an effect on toxicity, quality of life, or oncologic outcomes.Conclusions: With early FU, ultra large prostate glands do not portend increased risk of high-grade toxicity after SBRT but likely carry an elevated risk of low-grade GU toxicity.
'I don't like it': A comparative analysis of emotions in the political rhetoric of Pauline Hanson from 1996-1998 and 2016-2018
Creators: name: Miles, Aprill
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: In Australian politics and popular culture, few politicians have ever been considered as controversial as Pauline Hanson. From 60 Minutes to Pauline Pantsdown, from The House of Representatives to Dancing With the Stars and The Celebrity Apprentice, Hanson has barely left the public imagination since her explosive entrance into politics in the 1996 federal election. Hanson's successful 2016 election to the Senate has once again brought her firmly into the spotlight and raised questions of how Hanson succeeded a second time. While Hanson has been discredited on both the political left and right as the 'ignorant' and 'racist' voice of a minority, our most outcast members of the Government can show us surprising cultural truths. This thesis explores how Pauline Hanson's political discourse has changed over the last 18 years and the role that emotions play in her speeches. Through a content and an applied thematic analysis of Hanson's Parliamentary speeches from 1996-1998 and 2016-2018, this thesis will highlight the mirroring of emotional regimes of the radical populist right in the Australian political sphere.
Aerosol optical properties and direct radiative forcing based on measurements from the China Aerosol Remote Sensing Network (CARSNET) in eastern China
Creators: name: Che, Huizheng
name: Qi, Bing
name: Zhao, Hujia
name: Xia, Xiangao
name: Eck, Thomas
name: Et Al.
Publisher: name: EGU
Year: 2018

description: Authors: - Huizheng Che, Bing Qi, Hujia Zhao, Xiangao Xia, Thomas F. Eck, Philippe Goloub, Oleg Dubovik, Victor Estelles, Emilio Cuevas-Agulló, Luc Blarel, Yunfei Wu, Jun Zhu, Rongguang Du, Yaqiang Wang, Hong Wang, Ke Gui, Jie Yu, Yu Zheng, Tianze Sun, Quanliang Chen, Guangyu Shi, and Xiaoye Zhang
description: Aerosol pollution in eastern China is an unfortunate consequence of the region's rapid economic and industrial growth. Here, sun photometer measurements from seven sites in the Yangtze River Delta (YRD) from 2011 to 2015 were used to characterize the climatology of aerosol microphysical and optical properties, calculate direct aerosol radiative forcing (DARF) and classify the aerosols based on size and absorption. Bimodal size distributions were found throughout the year, but larger volumes and effective radii of fine-mode particles occurred in June and September due to hygroscopic growth and/or cloud processing. Increases in the fine-mode particles in June and September caused AOD₄₄₀ ₙₘ > 1.00 at most sites, and annual mean AOD₄₄₀ ₙₘ values of 0.71–0.76 were found at the urban sites and 0.68 at the rural site. Unlike northern China, the AOD₄₄₀ ₙₘ was lower in July and August (∼ 0.40–0.60) than in January and February (0.71–0.89) due to particle dispersion associated with subtropical anticyclones in summer. Low volumes and large bandwidths of both fine-mode and coarse-mode aerosol size distributions occurred in July and August because of biomass burning. Single-scattering albedos at 440 nm (SSA₄₄₀ ₙₘ) from 0.91 to 0.94 indicated particles with relatively strong to moderate absorption. Strongly absorbing particles from biomass burning with a significant SSA wavelength dependence were found in July and August at most sites, while coarse particles in March to May were mineral dust. Absorbing aerosols were distributed more or less homogeneously throughout the region with absorption aerosol optical depths at 440 nm ∼ 0.04–0.06, but inter-site differences in the absorption Angström exponent indicate a degree of spatial heterogeneity in particle composition. The annual mean DARF was −93 ± 44 to −79 ± 39 W m⁻² at the Earth's surface and ∼ −40 W m⁻² at the top of the atmosphere (for the solar zenith angle range of 50 to 80∘) under cloud-free conditions. The fine mode composed a major contribution of the absorbing particles in the classification scheme based on SSA, fine-mode fraction and extinction Angström exponent. This study contributes to our understanding of aerosols and regional climate/air quality, and the results will be useful for validating satellite retrievals and for improving climate models and remote sensing algorithms.
Exploring Localization in Nuclear Spin Chains
Creators: name: Wei, Ken Xuan
name: Ramanathan, Chandrasekhar
name: Cappellaro, Paola
Publisher: name: arXiv
Year: 2016
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Characterizing out-of-equilibrium many-body dynamics is a complex but crucial task for quantum applications and the understanding of fundamental phenomena. A central question is the role of localization in quenching quantum thermalization, and whether localization survives in the presence of interactions. The localized phase of interacting systems (many-body localization, MBL) exhibits a long-time logarithmic growth in entanglement entropy that distinguishes it from the noninteracting Anderson localization (AL), but entanglement is difficult to measure experimentally. Here, we present a novel correlation metric, capable of distinguishing MBL from AL in high-temperature spin systems. We demonstrate the use of this metric to detect localization in a natural solidstate spin system using nuclear magnetic resonance (NMR). We engineer the natural Hamiltonian to controllably introduce disorder and interactions and observe the emergence of localization. In particular, while our correlation metric saturates for AL, it keeps increasing logarithmically for MBL, a behavior reminiscent of entanglement entropy, as we confirm by simulations. Our results show that our NMR techniques, akin to measuring out-of-time correlations, are well suited for studying localization in spin systems.
description: 6 + 11 pages, comments are welcome
Absolute efficiency of a two-stage microchannel plate for electrons in the 30 - 900 eV energy range
Creators: name: Apponi, A.
name: Pandolfi, F.
name: Rago, I.
name: Cavoto, G.
name: Mariani, C.
name: Ruocco, A.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: We report on an apparatus able to measure the absolute detection efficiency of a detector for electrons in the 30 - 900 eV range. In particular, we discuss the characterisation of a two-stage chevron microchannel plate (MCP). The measurements have been performed in the LASEC laboratory at Roma Tre University, whit a custom-made electron gun. The very good stability of the beam current in the fA range, together with the picoammeter nominal resolution of 0.01 fA, allowed the measurement of the MCP absolute efficiency $ε$. We found an $ε$ = (0.489 $\pm$ 0.003) with no evident energy dependence. We fully characterised the MCP pulse shape distribution, which is quasi-Gaussian with a well visible peak above the noise level. We measured a 68% variation of the average pulse height between 30 and 500 eV. Furthermore, with a deeper analysis of the pulse shape, and in particular of the correlation between pulse height, area and width, we found a method to discriminate single- and multi- electron events occurring within a 10 ns time window.
description: 15 pages, 25 figures
Highly specific host-pathogen interactions influence Metarhizium brunneum blastospore virulence against Culex quinquefasciatus larvae
Creators: name: Alkhaibari, Abeer M.
name: Lord, Alex M.
name: Maffeis, Thierry
name: C. Bull, James
name: Olivares, Fabio L.
name: Samuels, Richard I.
name: M. Butt, Tariq
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Evolutionary Biology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology
subject: Computational Biology

description: Entomopathogenic fungi are potential biological control agents of mosquitoes. Our group observed that not all mosquitoes were equally susceptible to fungal infection and observed significant differences in virulence of different spore types. Conidiospores and blastospores were tested against Culex quinquefasciatus larvae. Blastospores are normally considered more virulent than conidia as they form germ tubes and penetrate the host integument more rapidly than conidia. However, when tested against Cx. quinquefasciatus, blastospores were less virulent than conidia. This host-fungus interaction was studied by optical, electron and atomic force microscopy (AFM). Furthermore, host immune responses and specific gene expression were investigated. Metarhizium brunneum (formerly M. anisopliae) ARSEF 4556 blastospores did not readily adhere to Culex larval integument and the main route of infection was through the gut. Adhesion forces between blastospores and Culex cuticle were significantly lower than for other insects. Larvae challenged with blastospores showed enhanced immune responses, with increased levels of phenoloxidase, glutathione-S-transferase, esterase, superoxide dismutase and lipid peroxidase activity. Interestingly, M. brunneum pathogenicity/stress-related genes were all down-regulated in blastospores exposed to Culex. Conversely, when conidia were exposed to Culex, the pathogenicity genes involved in adhesion or cuticle degradation were up-regulated. Delayed host mortality following blastospore infection of Culex was probably due to lower adhesion rates of blastospores to the cuticle and enhanced host immune responses deployed to counter infection. The results here show that subtle differences in host-pathogen interactions can be responsible for significant changes in virulence when comparing mosquito species, having important consequences for biological control strategies and the understanding of pathogenicity processes.
Genetic diversity of 23 STR loci in Guangxi Zhuang population and its phylogenetic relationship with other 25 populations
Creators: name: Zhang, Li
name: Zhu, Shisheng
name: Yang, Fan
name: Bai, Xue
name: Yao, Yiren
name: Li, Jianbo
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Aim: To estimate genetic diversity of 23 STR loci included in the DNA TyperTM 25 Kit, and evaluate its effectiveness in forensic application. Subjects and methods: A total of 450 (251 males and 179 females) unrelated healthy individuals from Guangxi Zhuang population were amplified with DNA TyperTM 25 Kit, isolated by a/the? 3730 analyzer and genotyped using the GeneMapper ID-X. Genetic parameters and population relationships were analysed. Results: Allele frequencies ranged from 0.001 to 0.5889. The combined power of discrimination (CPD) and the combined power of exclusion (CPE) of the 23 STR loci were 0.999999999999999999 and 0.999996765, respectively. No deviations from Hardy-Weinberg equilibrium and linkage disequilibrium were observed. Inter-population comparison based on Fst, PCA, genetic distance, phylogenetic trees and MDS showed that Zhuang population clustered with the population which holds a close geographic distance with Zhuang (Guangdong Han and Hainan Li populations). Conclusions: Our study indicated that the 23 autosomal STR loci included in DNA TyperTM 25 Kit can be used as forensic tools for individual identification and parentage testing. Moreover, the result of our mass investigation will enrich the forensic database of Chinese populations and serve for further study of the origin of anthropology.
Genotype-specific acquisition, evolution and adaptation of characteristic mutations in hepatitis E virus
Creators: name: Ikram, Aqsa
name: Hakim, Mohamad S.
name: Zhou, Jian-hua
name: Wang, Wenshi
name: Peppelenbosch, Maikel P.
name: Pan, Qiuwei
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Hepatitis E virus (HEV) infection is a major cause of acute hepatitis but also provokes chronic infection in immunocompromised patients. Although the pathogenesis and treatment outcome involve complex interplay between the virus and host, the nature of adaptive responses of HEV to the host immune system remain obscure at best. In this study, we used large-scale proteomic bioinformatics to profile characteristic mutations in human HEV isolates associated to ribavirin treatment failure, chronic hepatitis, hepatic failure or altered immunoreactivity. The prevalence of specific mutations was examined in a large number of protein sequences of ORF1 and ORF2 regions of the 3 major human-derived HEV genotypes (1, 3 and 4). By analyzing potential B, CD4+ and CD8+ T cell epitopes, we found that many of these mutations overlap with the predicted epitopes and are frequently present among the 3 HEV genotypes. These overlapping mutations mediate reduced antigenicity. Finally, by delineation of diversification and evolution of the underlying epitopes, we observe that most of these variants apparently evolved earlier in genotype 1 when compared with genotypes 3 and 4. These results indicate that HEV is under substantial evolutionary pressure to develop mutations enabling evasion of the host immune response and resistance to antiviral treatment. This indicates the existence of an ongoing evolutionary arms race between human immunity, antiviral medication and HEV.
The eyes and ears of the king: a study on a set of designations and the 18th Dynasty officials who held them
Creators: name: Chapman, David A. T.
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: In the 18th dynasty, high officials often held the designations "eyes of the King" and" ears of the king". These eyes-and-ears appellations can firmly be identified in 49 text excerpts. These enigmatic phrases are associated with 35 individuals between the co-rule of Hatshepsut and Thutmosis III and the aftermath of the Amarna episode. Despite the substantial body of evidence relating to these appellations, scholars have not up until now thoroughly considered this dataset. A variety of interpretations of royal sense-organ designations have emerged in the literature regardless, and scholars have been unable to come to agreement as to their meaning. Some authors regard these entities as titles of occupation or rank, while others suggest it is used to indicate an official's closeness or level of trust with the monarch. This study has principally been concerned with discerning whether patterns can be detected in the linguistic features and construction of the phrases, their wider textual context, and the social milieu and careers of the officials who held them. The study found there are some commonalities in the linguistic elements of constructions and their co-text, however, there is not a single factor which unites the officials who acquired these appellations.
Processes in Reading Chinese as a Second or Heritage Language: Reading Performance, Problems and Problem-solving Strategies
Creators: name: Li, Xinxin
Publisher: name: Monash University
Year: 2020
Subjects: classificationCode: 470303
subject: Chinese languages
classificationCode: 520405
subject: Psycholinguistics (incl. speech production and comprehension)

description: Learning to read in Chinese poses unique challenges due to the nature of the Chinese writing system.
This study examined the reading process for second language and heritage language learners studying Chinese in Australia, with either intermediate or advanced competence. It explored reading problems and problem-solving strategies, and the differences and similarities between the groups. Both second language and heritage learners had difficulty with character and word recognition. However, heritage learners were able to draw on superior underlying linguistic knowledge, and faced fewer problems related to cultural knowledge than the second language learners.
Additional file 5: of Insulin-like growth factor receptor and sphingosine kinase are prognostic and therapeutic targets in breast cancer
Creators: name: Ochnik, Aleksandra
name: Baxter, Robert
Publisher: name: figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer

description: Breast cancer cell viability dose curves in response to SKI-II. Refer to Fig. 5 for experimental details. A. MCF7, B. T47D, C. HCC-1806 and D. HCC70 were treated with single agents of the SphK1 inhibitor (SKI-II; 0.16, 0.8, 4, 10 and 20 μM) for 96 h. Graphs depict experimental data normalized to zero treatment vehicle control and 1-way ANOVA followed by Tukey’s test was performed to determine significance between treatment groups and significance accepted p-values *p
Temporal trends in mortality location in patients with anal cancer in the USA: an analysis of the National Center for Health Statistics mortality data
Creators: name: Sohail, Amir H.
name: Williams, Caroline E.
name: Schiller, Emily
name: Ye, Ivan B.
name: Orozco, Ronald
name: Hakmi, Hazim
name: Shahjehan, Faisal
name: Ali, Hassam
name: K Gangwani, Manesh
name: Aziz, Muhammad
name: Hayat, Umar
name: Maan, Soban
name: Akhtar, Aisha
name: Symer, Matthew
Publisher: name: PRIME
Year: 2024
Subjects: classificationCode: 420316
subject: Palliative care

description: AbstractObjectives: Investigate trends in where patients died of anal cancer in the USA.Methods: Retrospective cohort study using the US National Center for Health Statistics Wide-Ranging ONline Data for Epidemiologic Research platform from 2003 to 2020; all patients with death certificates listing anal cancer as the underlying cause of death in the USA. Main outcome measure of location of patient death: inpatient facility, home, hospice, nursing home/long-term care facility and other.Results: There were a total of 16 296 deaths with anal cancer as the underlying diagnosis during the study period. The crude rate increased from 0.191 per 100 000 deaths in 2003 to 0.453 per 100 000 deaths in 2020. Over the study period, 22.4% of patient deaths occurred in inpatient facilities, 44.9% at home, 12.2% at hospice facilities and 13.1% at nursing homes/long-term care facilities. The percentage of deaths occurring in hospice facilities increased from 1.0% to 13.3% during the study period. Deaths at home also increased from 42.7% in 2003 to 55.8% in 2020. Meanwhile, inpatient deaths decreased from 33.5% in 2003 to 14.4% in 2020.Conclusions: There has been a significant increase in the proportion of patients with anal cancer dying at home or hospice from 2003 to 2020.
Observing a quantum Maxwell demon at work
Creators: name: Cottet, N.
name: Jezouin, S.
name: Bretheau, L.
name: Campagne-Ibarcq, P.
name: Ficheux, Q.
name: Anders, J.
name: Auffèves, A.
name: Azouit, R.
name: Rouchon, P.
name: Huard, B.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: In apparent contradiction to the laws of thermodynamics, Maxwell's demon is able to cyclically extract work from a system in contact with a thermal bath exploiting the information about its microstate. The resolution of this paradox required the insight that an intimate relationship exists between information and thermodynamics. Here, we realize a Maxwell demon experiment that tracks the state of each constituent both in the classical and quantum regimes. The demon is a microwave cavity that encodes quantum information about a superconducting qubit and converts information into work by powering up a propagating microwave pulse by stimulated emission. Thanks to the high level of control of superconducting circuits, we directly measure the extracted work and quantify the entropy remaining in the demon's memory. This experiment provides an enlightening illustration of the interplay of thermodynamics with quantum information.
Additional file 1: Table S1. of Life-history strategy, resource dispersion and phylogenetic associations shape dispersal of a fig wasp community
Creators: name: Vignesh Venkateswaran
name: Shrivastava, Amitabh
name: Anusha Kumble
name: Borges, Renee
Publisher: name: figshare
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: Plant Biology
subject: Computational Biology

description: Dispersal-trait parameter values (untransformed means and standard deviations) for each fig wasp species in the Ficus racemosa community. Figure S1. Length of oviposition windows associated with each fig wasp species in relation to the developmental ontogeny of the syconium. Figure S2. Results of the phenogram generated using cluster analysis. Figure S3. Methods for quantifying dispersal capacity of fig wasps. Figure S4. Putative phylogenetic relationships of wasp species of F. racemosa. (DOC 778Â kb)
title: ADCO, Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.1 (début XIIIe siècle), Cart. 166 (11 H 64), 136 folios, f. 0096v
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.1 (début XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 166 (11 H 64), 136 folios, f. 0096v, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.1 (début XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 166 (11 H 64), 136 folios, f. 0096v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
Test of the local form of higher-spin equations via AdS/CFT
Creators: name: Didenko, V. E.
name: Vasiliev, M. A.
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The local form of higher-spin equations found recently to the second order [1] is shown to properly reproduce the anticipated $AdS/CFT$ correlators for appropriate boundary conditions. It is argued that consistent $AdS/CFT$ holography for the parity-broken boundary models needs a nontrivial modification of the bosonic truncation of the original higher-spin theory with the doubled number of fields, as well as a nonlinear deformation of the boundary conditions in the higher orders.
description: 18 pages, Typos and acknowledgement corrected. Misleading notation in Section 4.2 changed. References corrected
Self-consistent radiative corrections to false vacuum decay
Creators: name: Garbrecht, Bjorn
name: Millington, Peter
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: With the Higgs mass now measured at the sub-percent level, the potential metastability of the electroweak vacuum of the Standard Model (SM) motivates renewed study of false vacuum decay in quantum field theory. In this note, we describe an approach to calculating quantum corrections to the decay rate of false vacua that is able to account fully and self-consistently for the underlying inhomogeneity of the solitonic tunneling configuration. We show that this method can be applied both to theories in which the instability arises already at the level of the classical potential and those in which the instability arises entirely through radiative effects, as is the case for the SM Higgs vacuum. We analyse two simple models in the thin-wall regime, and we show that the modifications of the one-loop corrections from accounting fully for the inhomogeneity can compete at the same level as the two-loop homogeneous corrections.
description: 10 pages, 8 figures. Prepared for the proceedings of DISCRETE2016: the Fifth Symposium on Prospects in the Physics of Discrete Symmetries, 28 November-3 December 2016, University of Warsaw, Poland, to appear in the Journal of Physics: Conference Series (JPCS). Presented by P. Millington
Live load analysis of existing masonry arch bridges without plans
Creators: name: Turiano, Kara
Publisher: name: No Publisher Supplied
Year: 2022

description: Many masonry arch bridges across the United States are historical structures and in need of evaluation and rehabilitation. As vehicular traffic increases, it is critical to analyze these structures with modern live loading requirements. Specifically, for masonry arches in New Jersey, guidance is limited for rating live load under the New Jersey Department of Transportation Design Manual for Bridges and Structures, AASHTO LRFD Bridge Design Specifications and AASHTO Manual for Bridge Evaluation and is generally modified from the guidance specified for three-sided flat culverts. Contributing to the complexity of the live load rating of existing masonry arch bridges is the frequent lack of available or informative “As-Built” plans.The objective of this thesis is to provide a standard procedure to evaluate moving vehicular lives loads on existing masonry arch bridges. The procedure will include specifications for modeling arch bridges in STAAD Pro analysis software, determining controlling load cases for moving live loads using the analysis software, longitudinal and transverse distribution of wheel loads through soil fill and final distributed loads on arch for multiple single-span sample bridges. The thesis will also generate guidance for determining reasonable assumptions regarding unknown or limited properties, geometry or capacity of arch ring or foundations. These results will be compared to previous live load ratings of the sample bridges to assess the response to assumptions and the simplicity and accuracy of the various methods.
Additional file 1 of Development and validation of a gradient boosting machine to predict prognosis after liver resection for intrahepatic cholangiocarcinoma
Creators: name: Ji, Gu-Wei
name: Jiao, Chen-Yu
name: Xu, Zheng-Gang
name: Li, Xiang-Cheng
name: Wang, Ke
name: Wang, Xue-Hao
Publisher: name: figshare
Year: 2022
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Mathematical Sciences not elsewhere classified
Cancer

description: Additional file 1: Fig. S1. Scatter plot of gradient boosting machine-based prediction scores in the training/validation and test cohort. Scores are reported as median (interquartile range). Fig. S2. X-tile analysis to determine the optimal cut-points for GBM-based prediction scores. The optimal cut-points highlighted by black circle (A) are detailed in histogram of the training/validation cohort (B) with corresponding Kaplan-Meier curves (C). GBM gradient boosting machine. Table S1. Comparison of proposed and existing prognostic tools for ICC in sub-cohort with or without missing covariates. Table S2. Comparison of demographic and clinicopathological characteristics among different risk groups
The Late-Type Extension to MoVeRS (LaTE-MoVeRS): Proper motion verified low-mass stars and brown dwarfs from SDSS, 2MASS, and WISE
Creators: name: Theissen, Christopher A.
name: West, Andrew A.
name: Shippe, Guillaume
name: Burgasser, Adam J.
name: Schmidt, Sarah J.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present the Late-Type Extension to the Motion Verified Red Stars (LaTE-MoVeRS) catalog, containing 46,463 photometric late-type ($>$ M5) dwarfs within the Sloan Digital Sky Survey (SDSS) footprint. Proper motions were computed for objects combining astrometry from the SDSS Data Release 12 (DR12), the Two-Micron All-Sky Survey (2MASS) Point Source Catalog (PSC), and the \emph{Wide-field Infrared Survey Explorer} (\emph{WISE}) AllWISE datasets. LaTE-MoVeRS objects were required to have significant proper motion ($μ_\mathrm{tot} \geqslant 2σ_{μ_\mathrm{tot}}$). Using the LaTE-MoVeRS sample and \emph{Gaia} Data Release 1, we estimate \emph{Gaia} will be $\sim$64\% complete for very-low-mass objects ($>$ M5) in comparison to the combined SDSS+2MASS+\emph{WISE} dataset ($i < 21.3$). We computed photometric distances and estimated stellar effective temperatures for the LaTE-MoVeRS catalog. The majority of the dwarfs in the sample have distances $< 150$ pc and $T_\mathrm{eff} < 3000$ K. Thirteen objects were identified within LaTE-MoVeRS with estimated photometric distances within 25 pc that have not been previously identified as nearby objects. We also identified one new object with a large amount of excess mid-infrared flux that has not been previously identified (2MASS J11151597$+$1937266). This object appears to be an L2$γ$ at $\sim$50 pc showing spectroscopic signs of a flaring event (e.g., strong Hydrogen Balmer emission lines). This object does not exhibit kinematics similar to any known kinematic association. The LaTE-MoVeRS catalog is available through SDSS CasJobs and VizieR.
description: Accepted for publication in AJ. 18 pages including 14 figures and 5 tables
Minding the gender gap in MBA study
Creators: name: Wood, Michelle
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: The research reported in this thesis examined the barriers women face in pursuing postgraduate study in business, and why these barriers may be less salient for men. It also examines some potential ways to overcome these barriers. It involved thirty-eight, one-hour in-depth interviews with men (n=9) and women (n=29) who are either (a) considering doing an MBA, (b) in the middle of doing an MBA, or (c) MBA graduate. The interviews were transcribed, and a qualitative analysis of the resulting textual data was performed. Many of the themes captured by the interview data are grounded in previous research on the gender gap in MBAs, but some of the emergent themes have no obvious counterpart in the literature. This includes that women complete MBAs to overcome perceived personal deficits, that they are deterred from MBA study because they perceive the work/life juggle too difficult to manage (as opposed to the difficulty of the study itself) and that by better linking study with a postXMBA leadership pathway, as well as aligning students with mentors/sponsors, employers have a significant role to play in increasing the numbers of female MBAs.
Novel small molecule modulators of quorum sensing in avian pathogenic Escherichia coli (APEC)
Creators: name: Helmy, Yosra A.
name: Deblais, Loic
name: Kassem, Issmat I.
name: Kathayat, Dipak
name: Rajashekara, Gireesh
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Colibacillosis caused by avian pathogenic E. coli (APEC), is an economically important bacterial disease of poultry. APEC are a subgroup of extra intestinal pathogenic E. coli (ExPEC) and poultry are considered potential sources of foodborne ExPEC to humans. Currently, APEC infections in poultry are controlled by antibiotics and/or vaccination; however, their effect is limited due to emergence of antibiotic resistant strains and infections with heterologous serotypes. Therefore, novel approaches are needed. Here, using the bioluminescent quorum sensing (QS) autoinducer 2 (AI-2) indicator Vibrio harveyi BB170, we screened the cell free culture supernatant of APEC O78 prepared from cultures grown in the presence of 4,182 small molecules (SMs; 100 μM). A total of 69 SMs inhibited > 75% of APEC O78 AI-2 activity in the indicator bacteria. Ten SMs that showed highest AI-2 inhibition were selected for further studies. Most of these SMs inhibited the AI-2 activity of other APEC serotypes and significantly reduced APEC O78 biofilm formation and motility. Most compounds showed minimal toxicity on human intestinal cells (Caco-2), chicken macrophage (HD-11), and chicken and sheep red blood cells, and reduced APEC survival in HD-11 and THP-1 macrophages. The SMs induced no or minimal toxicity and conferred protection against APEC in wax moth larval model. SMs affected the expression of APEC O78 QS, virulence, biofilm and motility associated genes providing insight on their potential mode(s) of action. Further testing in chickens will facilitate development of these SMs as novel therapeutics to control APEC in poultry and thereby also reduce zoonotic transmission.