cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Growth dynamics of a Bose-Einstein condensate in a dimple trap without cooling
Creators: name: Garrett, Michael C.
name: Ratnapala, Adrian
name: Van Ooijen, Eikbert D.
name: Vale, Christopher
name: Weegink, Kristian
name: Schnelle, Sebastian K.
name: Vainio, Otto
name: Heckenberg, Norman R.
name: Rubinsztein-Dunlop, Halina
name: Davis, Matthew J.
Publisher: name: Swinburne
Year: 2024

description: We study the formation of a Bose-Einstein condensate in a cigar-shaped three-dimensional harmonic trap, induced by the controlled addition of an attractive 'dimple' potential along the weak axis. In this manner we are able to induce condensation without cooling due to a localized increase in the phase-space density. We perform a quantitative analysis of the thermodynamic transformation in both the sudden and adiabatic regimes for a range of dimple widths and depths. We find good agreement with equilibrium calculations based on self-consistent semiclassical Hartree-Fock theory describing the condensate and thermal cloud. We observe that there is an optimal dimple depth that results in a maximum in the condensate fraction. We also study the nonequilibrium dynamics of condensate formation in the sudden turn-on regime, finding good agreement for the observed time dependence of the condensate fraction with calculations based on quantum kinetic theory.
Analysis of interactions with the mammalian deubiquitinating enzyme, USP4
Creators: name: Twomey, Erin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Chemistry, Biochemistry.

description: We have previously reported the cloning of the murine USP4 (previously Unp) and human USP4 (previously Unph) genes. These genes encode ubiquitin specific proteases capable of cleaving ubiquitin tags from synthetic substrates in vitro. However, the natural substrates of this deubiquitinating enzyme are not known. It has been shown that USP4-overexpressing NIH3T3 cells consistently produce tumors in nude mice experiments and USP4 has been implicated in specific types of human lung tumors such as small cell and adenocarcinomas. Unlike some other deubiquitinating enzymes, USP4 does not have an overall affect on cellular ubiquitination. Therefore, it is thought that USP4 has only one or a few substrates and that it may be functioning by stabilizing a protein by editing its ubiquitin degradation signal. As a first step in attempting to identify USP4's substrate(s), we have been looking for proteins that may interact with USP4. We have done this using an in vitro pull down system and mass spectrometry analysis. The translational elongation factor, EF1A, was identified by mass spectrometry and this interaction was confirmed in vivo using immunoprecipitations and immunofluorescence.
Is it feasible to integrate and harmonise national surveys on working conditions? A scoping paper (Deliverable 11.5)
Creators: name: Desiere, Sam
name: Lenaerts, Karolien
Publisher: name: Zenodo
Year: 2020

description: The InGRID-1 project prepared an inventory of national surveys on working conditions in the EU. This InGRID-2 scoping paper examines whether these surveys can be harmonised and integrated. To do so, national surveys on working conditions in the Netherlands and Germany were compared to the European Working Conditions Survey (EWCS), the only EU-wide survey on working conditions. The conclusion of this exercise is that the existing national surveys cannot be harmonised and integrated in the short or medium term. While this working paper presents evidence that responses to similar questions are comparable between surveys (e.g. the same share of the employees report being satisfied with their working conditions in the EWCS as in the national surveys), the questionnaires contain only a few similar questions. Coupled with large differences in the aim and scope of the national surveys, their population and sample, the timing and other points further complicate this exercise. Rather than investing in the harmonisation and integration of national working conditions surveys, it seems more cost-effective to invest in and strengthen the EWCS if one wants to build EU-wide indicators on working conditions.
Content delivery networks
Creators: name: Chao, Yaxin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Education, Technology of.
subject: Engineering, System Science.

description: Since bottlenecks and congestion often happen with the phenomenal growth in the use of the network, the demand for improving network delivered performance is very necessary. Deploying Content Delivery Networks (CDNs) technology to improve delivery performance has caused more and more people's attention. Content Delivery Networks employ many geographically distributed sites to improve the scalability and improves network performance by reducing the client's response time. In this thesis, we initially present the background knowledge on CDNs, which includes CDNs concept, function, methodology, components and market analysis. The thesis emphasizes analyzing, comparing and evaluating various aspects of CDNs. We divide the whole comparison and evaluation into three parts. Firstly, we analyze and compare CDNs to other methods for improving performance and congestion control. Secondly, we overview different technologies that can be used within CDNs, then compare and analyze various CDNs components and implementations. Thirdly, we select current representative CDNs companies or providers to compare and evaluate their products and services. In this thesis, we also describe some main applications of CDNs and do a case study of Cisco ECDN and Volera Velocity CDN for E-learning. Finally, we conclude this thesis by summarizing our analysis and giving recommended trends for CDNs development.
Social capital and housing tenure in an Adelaide neighbourhood
Creators: name: Ziersch, Anna
name: Arthurson, Kathy
Publisher: name: Swinburne
Year: 2024

description: In this article we compare and contrast elements of social capital across different housing tenures in an Adelaide neighbourhood. Using the results of 530 self-completion questionnaires and in-depth qualitative interviews with 16 people we assess perceptions of conflict across housing tenures and between socio-economic groups, feelings of acceptance and belonging in the local neighbourhood, and levels of involvement in local formal and informal networks. While only a small number of questionnaire respondents reported negative views of socio-economic diversity in the area a theme emerging in the qualitative data indicated that housing tenure was relevant to some of these negative perceptions. Respondents from across different tenure types also reported differences in feelings of acceptance in the neighbourhood, and involvement in formal and informal networks. The study findings suggest that housing tenure is relevant to the development of neighbourhood-based social capital, and that this factor needs to be considered by social planners, housing policy makers and others involved in implementing social mix policies. In addition, the findings indicate the need to consider the community housing and public housing tenures in their own right, given the different models of housing provision, rather than collectively under the common banner of social housing as most research studies do. It is recommended that the full diversity of housing tenure is considered in any future analysis.
3D shape analyses of extant primate and fossil hominin vertebrae support the ancestral shape hypothesis for intervertebral disc herniation
Creators: name: Plomp, Kimberly A
name: Dobney, Keith
name: Weston, Darlene A
name: Strand Viðarsdóttir, Una
name: Collard, Mark
Publisher: name: BioMed Central
Year: 2019

description: Background: Recently we proposed an evolutionary explanation for a spinal pathology that afflicts many people, intervertebral disc herniation (Plomp et al. [2015] BMC Evolutionary Biology 15, 68). Using 2D data, we found that the bodies and pedicles of lower vertebrae of pathological humans were more similar in shape to those of chimpanzees than were those of healthy humans. Based on this, we hypothesized that some individuals are more prone to intervertebral disc herniation because their vertebrae exhibit ancestral traits and therefore are less well adapted for the stresses associated with bipedalism. Here, we report a study in which we tested this “Ancestral Shape Hypothesis” with 3D data from the last two thoracic and first lumbar vertebrae of pathological Homo sapiens, healthy H. sapiens, Pan troglodytes, and several extinct hominins. Results: We found that the pathological and healthy H. sapiens vertebrae differed significantly in shape, and that the pathological H. sapiens vertebrae were closer in shape to the P. troglodytes vertebrae than were the healthy H. sapiens vertebrae. Additionally, we found that the pathological human vertebrae were generally more similar in shape to the vertebrae of the extinct hominins than were the healthy H. sapiens vertebrae. These results are consistent with the predictions of the Ancestral Shape Hypothesis. Several vertebral traits were associated with disc herniation, including a vertebral body that is both more circular and more ventrally wedged, relatively short pedicles and laminae, relatively long, more cranio-laterally projecting transverse processes, and relatively long, cranially-oriented spinous processes. We found that there are biomechanical and comparative anatomical reasons for suspecting that all of these traits are capable of predisposing individuals to intervertebral disc herniation. Conclusions: The results of the present study add weight to the hypothesis that intervertebral disc herniation in H. sapiens is connected with vertebral shape. Specifically, they suggest that individuals whose vertebrae are towards the ancestral end of the range of shape variation within H. sapiens have a greater propensity to develop the condition than other individuals. More generally, the study shows that evolutionary thinking has the potential to shed new light on human skeletal pathologies.
Supplementary document for Light-field-driven current control in solids with pJ-level laser pulses at 80 MHz repetition rate - 5167246.pdf
Creators: name: Hanus, Vaclav
name: Csajbók, Viktória
name: Pápa, Zsuzsanna
name: Budai, Judit
name: Marton, Zsuzsanna
name: kiss, Zsolt
name: Sándor, Péter
name: Paul, Pallabi
name: Szeghalmi, Adriana
name: Wang, Zilong
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary information
Gene expression during active cell death in involuting prostate and mammary gland: Cloning and characterization of regression-selected genes (RSG).
Creators: name: Guenette, Robert S.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Biology, Molecular.

description: Following hormonal ablation in the rat ventral prostate (via castration) or rat mammary gland (after weaning) the epithelial cells of both glands are eliminated by active cell death during the regression of the glands. Several genes including TRPM-2, (testosterone repressed prostate message), RVP.1, fos, and myc, have been shown to be induced in the prostate during this process. We have investigated the expression of several other genes that may be associated with apoptosis, including tissue transglutaminase (tTGase), poly (ADP-ribose) polymerase (PARP), and heat shock protein 27 (Hsp27). Northern hybridization has been used to determine the steady-state mRNA levels of these genes in both the regressing prostate and mammary glands. The time course of induction has been compared to changes in the steady state levels of several control genes including prostate steroid binding protein (PSBP) (prostate), $\beta$-casein (mammary), $\alpha$-tubulin, and TRPM-2 (both prostate and mammary). A novel cross-screening approach first described by Wong et al., 1989 was used to clone and characterize genes other than those described above which were induced during the regression of both rat prostate and mammary gland. Two regression selected genes (RSG) refered to as RSG-2, and RSG-8, were isolated, and their role in the active cell death process has been investigated. RSG-2 is homologous to cathepsin B, a thiol protease that has been previously identified as one of the extracellular proteases that is activated in metastatic cells. RSG-8, is homologous to rat insulin like growth factor binding protein 5 (IGFBP-5), a member of a group of six related proteins that are known to mediate the effects of the growth factors IGF-I, and IGF-II. The steady state level of IGFBP-5 mRNA in the normal prostate is low but detectable. In the regressing prostate, the mRNA for IGFBP-5 mRNA is induced and its steady state peaks in the luminal epithelial cells of the prostate that undergo active cell death (ACD) between 3 and 4 days after castration. The gene is induced in a similar fashion in the regressing mammary gland following weaning. The expression of another IGFBP, namely IGFBP-2 contrasts that of IGFBP-5, with a high steady state level in both prostate and mammary gland, which increase only slightly during the regression process. The increase in mRNA steady-state levels for both IGFBP-2 and IGFBP-S were shown by in-situ hybridization to localize to the epithelial cells that are deleted during the regression process. The differential expression of IGFBP-2 and IGFBP-5 suggest that modulating the epithelial cells response to the IGF growth factors may influence the active cell death process in hormonally dependent tissues such as the prostate and mammary gland. (Abstract shortened by UMI.)
title: Zu mentalen Konzepten im Bilingualismus
Creators: name: Huttner, Lena-Marie
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2019

description: Menschen die bilingual aufwachsen, müssen zwei oder mehr Bedeutungssysteme erwerben und aushandeln. Dabei stellt sich die Frage, wie die Konzepte bilingualer Sprecher entstehen und interagieren. Um diese Frage zu beantworten werden Bilingualismus und Konzepte in vorliegender Arbeit zunächst von theoretischer Seite betrachtet. Bilingualismus wird hierbei als der Erwerb zweier Erstsprachen im Kindesalter definiert. Konzepte stellen, als multimodale sensomotorische Repräsentationen, einen Teil der nicht-sprachlichen Kognition und des Denkens dar. Der Erwerb bilingualer Konzepte gestaltet sich dabei anders als der Erwerb des Vokabulars einer Fremdsprache. Demnach muss sich auch die konzeptuelle Organisation unterscheiden. Monolingual-sprachvergleichende Studien lassen vermuten, dass die konzeptuelle Ähnlichkeit der Wörter mit steigendem Abstraktionsgrad abnimmt. Um den Zusammenhang von Sprache und konzeptuellen Denken im Bilingualismus experimentell zu untersuchen, bewerteten spanisch-deutsch Bilinguale 15 übersetzungsgleiche Begriffe unterschiedlichen Abstraktionsgrades auf einem semantischen Differenzial. Eine später erlernte Fremdsprache, Englisch, wird ebenfalls in die Umfrage aufgenommen. Die Auswertung zeigt, dass sich abstrakte Begriffe am ähnlichsten sind, während konkrete Begriffe in ihrer konzeptuellen Ähnlichkeit weiter auseinander liegen. Die Ergebnisse der Studie zeigen, dass die Lexika monolingualer und bilingualer Sprecher nicht zu vergleichen sind. Das bilinguale mentale Lexikon bildet damit eine eigene, vollkommene Entität und unterscheidet sich vom monolingualen mentalen Lexikon.
Die Europäische Union - ein Erfolgsmodell für das 21. Jahrhundert?: Unbehagen an Europa
Creators: name: Gehler, Michael
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: BAG WiWA
subject: DGWF
subject: DDC 320 / Political science
subject: European Union
subject: Europagedanke
subject: Europäische Integration
subject: Europäische Union
subject: Online-Publikation
subject: Ringvorlesung

description: Die Zukunft der EU und der gegenwärtige Zustand Europas beherrschen die politischen Diskussionen unserer Tage. Nach einer Einführung zur Entstehung der Gemeinschaften widmet sich der Vortrag ihren institutionellen Strukturen (Aufbau und Funktionen) von der Montanunion bis zum Vertrag von Lissabon, Perzeptionen und Reaktionen sowie Fragen von Erosion und Zerfall der EU in stürmischen Krisenzeiten. Eine Bilanz und Zusammenfassung der Thematik werden ausreichend Anlässe bieten für ein Unbehagen mit dem Unbehagen gegenüber der Europäischen Union.
Searching for Variability in the Globular Cluster Messier 4
Creators: name: Ferdman, Robert D.
name: Richer, Harvey B.
name: Brewer, James
name: Fahlman, Greg G.
name: Gibson, Brad K.
name: Hansen, Brad M. S.
name: Huber, Mark E.
name: Ibata, Rodrigo A.
name: Kalirai, Jasonjot S.
name: Matthews, Jaymie M.
name: Rich, R. Michael
name: Rowe, Jason F.
name: Shara, Michael M.
name: Stetson, Peter B.
Publisher: name: Swinburne
Year: 2024

description: Time-series data taken with the Hubble Space Telescope of a field six core radii (∼5′) from the center of the globular cluster Messier 4, and covering a period of about 10 weeks in early 2001, have been analyzed in search of variable objects. Various criteria were employed to select candidate variable stars. Period searches were performed on the selected candidates using phase dispersion minimization (PDM). The reliability of the PDM search results was tested using synthetic light curves of eclipsing binary stars and sinusoidal light curves of different periods. Results from this analysis showed that there are probably no eclipsing binary stars or periodic variables in our field with periods on the order of a few hours to a few days, down to limiting magnitudes of V ∼ 25 and I ∼ 24, which is consistent with the absence of contact binaries such as W Ursae Majoris systems. However, one candidate variable star does show an increase in brightness of ∼ 0.1 mag in both bandpasses, which seems to last for a few days. Possible explanations concerning the nature of this object include a binary system with a white dwarf primary and a low-mass main-sequence secondary or a BY Draconis variable star. We are able to set an upper limit to the observed fraction of photometric variability in this data set of 0.05%.
Systematic parameter space study for the UHECR originfrom GRBs in models with multiple internal shocks
Creators: name: Heinze, Jonas
name: Biehl, Daniel
name: Fedynitch, Anatoli
name: Boncioli, Denise
name: Rudolph, Annika
name: Winter, Walter
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2020
Subjects: cosmic radiation: UHE
gamma ray: burst
sensitivity
propagation
stochastic
messenger
neutrino: flux
injection
stacking
quality

description: 16 pp. (2020).
description: We scrutinize the paradigm that conventional long-duration Gamma-Ray Bursts (GRBs) are the dominant source of the ultra-high energy cosmic rays (UHECRs) within the internal shock scenario by describing UHECR spectrum and composition and by studying the predicted (source and cosmogenic) neutrino fluxes. Since it has been demonstrated that the stacking searches for astrophysical GRB neutrinos strongly constrain the parameter space in single-zone models, we focus on the dynamics of multiple collisions for which different messengers are expected to come from different regions of the same object. We propose a model which can describe both stochastic and deterministic engines, which we study in a systematic way. We find that GRBs can indeed describe the UHECRs for a wide range of different model assumptions with comparable quality; the required heavy mass fraction at injection is found to be larger than 70% (95% CL). We demonstrate that the post-dicted (from UHECR data) neutrino fluxes from sources and UHECR propagation are indeed below the current sensitivities but will be reached by the next generation of experiments. We finally critically review the required source energetics with the specific examples found in this study.
EeV Astrophysical neutrinos from FSRQs?
Creators: name: Righi, C.
name: Palladino, A.
name: Tavecchio, F.
name: Vissani, F.
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2020
Subjects: neutrino: energy: high
neutrino: energy
neutrino: flux
energy: high
black hole
radio wave
spectrum
background
gamma ray
blazar
quasar

description: 10 pp. (2020).
description: Flat Spectrum Radio Quasars (FSRQ) are the most powerful blazars in the gamma-ray band. Although they are supposed to be good candidates in producing high energy neutrinos, no secure detection of FSRQs has been obtained up to now, except for a possible case of PKS B1424-418. In this work, we compute the expected flux of high energy neutrinos from FSRQs using standard assumptions for the properties of the radiation fields filling the regions surrounding the central supermassive black hole. We obtain as a result that high energy neutrinos are naturally expected from FSRQs in the sub-EeV-EeV energy range and not at PeV energies. This justifies the non-observation of neutrinos from FSRQs with the present technology, since only neutrinos below 10 PeV have been observed. We found that for a non-negligible range of the parameters the cumulative flux from FSRQs is comparable to or even exceeds the expected cosmogenic neutrino flux. This result is intriguing and highlights the importance to disentangle these point-source emissions from the diffuse cosmogenic background.
Routine cerebrospinal fluid (CSF) parameters in patients with spinal muscular atrophy (SMA) treated with nusinersen
Creators: name: Koch, Jan C.
name: Cordts, Isabell
name: Dreyhaupt, Jens
name: Otto, Markus
name: Uzelac, Zeljko
name: Witzel, Simon
name: Winter, Benedikt
name: Kocak, Tugrul
name: Schocke, Michael
name: Weydt, Patrick
name: Wollinsky, Kurt
name: Ludolph, Albert C.
name: Deschauer, Marcus
name: Lingor, Paul
name: Tumani, Hayrettin
name: Hermann, Andreas
name: Günther, René
name: Wurster, Claudia Diana
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: antisense-oligonucleotide
subject: routine CSF parameters
subject: lumbar puncture
subject: BARRIER DYSFUNCTION
subject: DIAGNOSIS
subject: PHASE-1
subject: DDC 610 / Medicine & health
subject: Muscular atrophy, Spinal
subject: Motor neuron disease
subject: Multiple sclerosis
subject: Proteins
subject: Spinal puncture
subject: Spinale Muskelatrophie
subject: Multiple Sklerose

description: Background: Nusinersen is an antisense-oligonucleotide (ASO) approved for treatment of 5q-spinal muscular atrophy (SMA). Since the drug cannot cross the blood-brain barrier (BBB), it must be administered into the cerebrospinal fluid (CSF) space repeatedly by lumbar puncture. However, little is known whether ASOs have an impact on CSF routine parameters that may yield information on CSF flow and/or intrathecal inflammation. The objective of this study was to examine CSF routine parameters in SMA patients treated with nusinersen. Methods: Routine CSF parameters [white cell count, total protein, CSF/serum quotients of albumin (Qalb), lactate, and oligoclonal IgG bands (OCB)] of 60 SMA patients (type 1, 2, and 3, aged 7–60 years) were retrospectively analyzed. Results: White cells ranged from 0 to 4/μL in CSF; a singular case of pleocytosis (8/μL) was observed in a patient in parallel with a systemic infection. Total protein and Qalb showed a mild increase from baseline to the following lumbar punctures (except for total protein in CSF at the fourth injection of nusinersen). Lactate levels revealed a stable course. In one patient, positive OCB in CSF were transiently observed. The slight change in total CSF protein and Qalb may be caused by repeated lumbar puncture and/or intrathecal administration of the drug. Conclusion: Our data suggest that a regular examination of routine CSF parameters in patients in which intrathecal ASOs are administered is important to obtain information on possible side effects and to gain further insights into intrathecal processes.
Supplementary document for Light-field-driven current control in solids with pJ-level laser pulses at 80 MHz repetition rate - 5167246.pdf
Creators: name: Hanus, Vaclav
name: Csajbók, Viktória
name: Pápa, Zsuzsanna
name: Budai, Judit
name: Marton, Zsuzsanna
name: kiss, Zsolt
name: Sándor, Péter
name: Paul, Pallabi
name: Szeghalmi, Adriana
name: Wang, Zilong
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: Supplementary information
Dark Matter and Dark Energy: Introduction, Development, and Gravitational Lensing
Creators: name: Khan, Ragib A.
Publisher: name: Zenodo
Year: 2024

description: Abstract

Scientists have solidified their understanding of dark matter and energy, confirming their existence. However, while dark energy has been observed and verified, dark matter remains elusive. The characteristics of these phenomena are still not fully comprehended, with dark matter remaining a theoretical construct. This article offers a summary of the historical context and contemporary advancements in the theories of dark matter and dark energy, along with the current areas of research, methodologies, preliminary scientific hypotheses, and key research techniques such as gravitational lensing for studying dark matter and energy.

Keywords: Baryonic matter, non-baryonic matter, MACHOs, WIMPs, gravitational lensing, thermal relics
Radiation-induced apoptosis and the adaptive response in human lymphocytes.
Creators: name: Cregan, Sean P.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Biology, Molecular.

description: Apoptosis is a genetically programmed cell death process which can be activated in cells by a variety of toxic agents including ionizing radiation. It has generally been assumed that radiation-induced DNA damage is responsible for activating the apoptotic process; however, some recent data suggests that oxidative damage of the plasma membrane may be more important. It has previously been reported that pre-exposure of mitogen-stimulated lymphocytes to a low dose of ionizing radiation can reduce the extent of chromosomal damage induced by a subsequent high dose radiation exposure. This phenomena has been termed an "adaptive response" to ionizing radiation and has been proposed to involve the induction of a DNA repair process by the low dose radiation exposure. In the present study we investigated the possibility that pre-exposure of lymphocytes to a low dose of ionizing radiation could modify the extent of apoptosis induced by a subsequent radiation exposure. Our results demonstrate that when lymphocytes from various donors were pre-exposed to a 0.1-Gy (adapting) dose of ionizing radiation the extent of apoptosis induced by a subsequent 2-Gy (challenge) dose of radiation was either significantly enhanced (mean increase of 26.1 +/- 6.8%) or did not change. This sensitization effect was shown to be significantly greater when the adapting exposure was given 6 hours prior to the challenge exposure than when it was given immediately before suggesting that the sensitization effect involves an induced cellular response and does not simply result from an additivity of the lesions produced by the two radiation exposures. Furthermore, we show that this increased sensitivity to radiation-induced apoptosis could be triggered in cells pre-exposed to either a low dose of ionizing radiation or a low concentration of t-butyl hydroperoxide. On the other hand, these pretreatments did not affect the level of apoptosis induced by exposure to a high concentration of the membrane oxidizing agent t-butyl hydroperoxide. Since an increase in the elimination of genetically damaged cells by apoptosis could reduce the risk of cancer from exposure to radiation or other DNA damaging agents, this cellular sensitization for apoptosis may represent a novel adaptive response mechanism. (Abstract shortened by UMI.)
Characterization of the repression of glucocorticoid-induced transcription of the mouse mammary tumor virus through negative regulatory element 1.
Creators: name: Rodda, David J.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Chemistry, Biochemistry.

description: The physiological effects of steroid hormones are mediated by their cognate receptors which regulate expression of target genes in response to binding of their steroid ligand. The mouse mammary tumor virus (MMTV) promoter is a widely used system for studying the effects of steroid hormones due to its strong activation by several classes of steroids. MMTV induces mammary tumors in female mice following lactation. T-cell lymphomas are also induced at much lower frequency and all cases of lymphoma that have been examined have deletions spanning a region of the long terminal repeat (LTR) from -421 to -364. This region has a transcriptional negative regulatory element called NRE1. Characterization of NRE1 revealed nuclear factors binding to the double-stranded (ds) form, as well as each of the single strands (up, lo - upper and lower strands respectively). A truncated element (MT) was also recognized but only the ds form. Kinetic studies showed binding occurred to the ds, up, to and MT with t1/2s of 11, 1.5, 3 and 4 min respectively. The off-rates (t1/2) were determined to be 60 min, 30 min, 12 h and 4 h respectively. Four factors were observed to bind NRE1 in southwestern analysis, while only one was observed binding to MT, that corresponded in mobility to the smallest NRE1 binding factor. The four factors appeared to cross-react with an octamer motif. The dsNRE1 binding factor was confirmed to recognize an octamer motif in EMSA. The dsNRE1 binding factor was identified as the Ku autoantigen heterodimer. It was demonstrated to bind directly to NRE1 with an affinity of Kd = 0.84 +/- 0.24 mum. Ku also bound upNRE1 with an affinity of K d = 3.5 +/- 1.3 mM. In kinetic analyses of purified Ku binding to upNRE1 the on-rate was determined to be t1/2 = 1.6 min, while the off rate was t1/2 = 68 min. Transient transfection assays using MMTV reporters either containing or lacking NRE1 were performed. Using cell lines not expressing functional Ku or its associated factor DNA-PK it was shown that both factors were required for the NRE1 mediated repression of glucocorticoid-induced transcription of MMTV. DNA-PK was shown to specifically phosphorylate a myc-tagged glucocorticoid receptor (GR) on serine 527 (5527) in vitro. A second phosphorylation site was determined to result from the addition of the myc tag, while a native receptor was phosphorylated only on S527. Transient transfections using 5527 mutants of GR demonstrated that substitution of S527 for alanine abrogated NRE1 mediated repression. The same effect was observed for glutamic acid and aspartic acid substitutions. We therefore conclude that binding of DNA-PK to NRE1 through its DNA binding subunit, Ku, allows it to phosphorylate GR on serine 527 resulting in a repression of glucocorticoid-induced transcription.
Proceedings of the Final conference of the EU project VIVALDI
Creators: name: ARZUL Isabelle
Publisher: name: Zenodo
Year: 2020
Subjects: bivalve diseases
aquatic diseases

description: VIVALDI (Preventing and Mitigating Farmed Bivalve Diseases) is a European scientific project, financed in the framework of the EU Research and Development programme called Horizon 2020. Carried out between 2016 and 2020 by a consortium of 21 partners, from 10 countries, VIVALDI’s overarching purpose was to increase the sustainability and competitiveness of the European shellfish industry. VIVALDI has not only improved the understanding of the diseases but also developed practical solutions to prevent, control and manage them. Results of the project have been presented during the final conference of the project organised in November 2019 in Brest (France). These proceedings present the abtrracts of the presentations.
Use of Systems Biology in Deciphering Mode of Action and Predicting Potentially Adverse Health Outcomes of Nanoparticle Exposure, Using Carbon Black as a Model
Creators: name: Bourdon, Julie A.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: Nanotoxicology
Systems Biology
Toxicogenomics
Toxicity Testing in the 21st Century

description: Nanoparticles (particles less than 100 nm in at least one dimension) exhibit chemical properties that differ from their bulk counterparts. Furthermore, they exhibit increased potential for systemic toxicities due to their deposition deep within pulmonary tissue upon inhalation. Thus, standard regulatory assays alone may not always be appropriate for evaluation of their full spectrum of toxicity. Systems biology (e.g., the study of molecular processes to describe a system as a whole) has emerged as a powerful platform proposed to provide insight in potential hazard, mode of action and human disease relevance. This work makes use of systems biology to characterize carbon black nanoparticle-induced toxicities in pulmonary and extra-pulmonary tissues (i.e., liver and heart) in mice over dose and time. This includes investigations of gene expression profiles, microRNA expression profiles, tissue-specific phenotypes and plasma proteins. The data are discussed in the context of potential use in human health risk assessment. In general, the work provides an example of how toxicogenomics can be used to support human health risk assessment.
Grafting and thermolysis of tetraneopentylzirconium on silica
Creators: name: Alladin, Tagenine
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Chemistry, Inorganic.

description: The gas-solid reaction of tetra(neopentyl)zirconium with the surface of Aerosil 200 pretreated thermally at 200°C has been investigated. Consistent with previous investigations of a similar reaction involving deposition of tetra(neopentyl)zirconium from solution, a unique supported organometallic fragment is formed. It was characterized by IR, 13C CP/MAS NMR, XAS and analytical techniques as (≡SiO)2Zr(CH2 C(CH3)3)2. Thermolysis of silica-supported bis(neopentyl)zirconium(IV) at ca. 120°C results in the extrusion of one equiv. of neopentane. The nature of the remaining surface organometallic fragment was inferred, by its reactivity in olefin metathesis as well as by curve-fitting of its EXAFS spectrum, to be neopentylidenezirconium(IV), presumably formed by alpha-H abstraction. This result is analogous to previously established transformations of bis(alkyl) complexes of titanium, vanadium and chromium supported on silica, but was unexpected since earlier reports of the thermolysis of Zr(CH2C(CH3)3) 4 supported gamma-H abstraction and the formation of a zirconacyclobutane intermediate. The alpha-H abstraction occurs with pseudo-first-order kinetics and activation parameters DeltaH‡ = 24(5) kJ/mol and DeltaS ‡ = -19(7) J/K•mol. Both the bis(neopentyl)- and neopentylidenezirconium(IV) fragments were found to catalyze polymerization of ethylene, at room temperature without any added cocatalyst. The reactions are pseudo-first-order in P(C2 H4).
Il capitalismo non è un termine evangelico. Una breve riflessione “sturziana” rileggendo l’Enciclica Caritas in veritate di Benedetto XVI
Creators: name: Barbieri, Luigi
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2012

description: SOMMARIO: 1. Economia e religione - 2. L’etica protestante e lo spirito del capitalismo - 3. L’etica cattolica e il capitalismo - 4. Il capitalismo buono e l’umanizzazione dell’economia - 5. Il capitalismo cattivo - 6. La riflessione di Luigi Sturzo.Brevi cenni.
description: Stato, Chiese e pluralismo confessionale, 2012: 15 ottobre
Fathers’ Views and Experiences of Creating a Smoke-Free Home : A Scoping Review
Creators: name: O’Donnell, Rachel
name: Angus, Kathryn
name: McCulloch, Peter
name: Amos, Amanda
name: Greaves, Lorraine
name: Semple, Sean
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2020

description: Enabling parents to create a smoke-free home is one of the key ways that children’s exposure to second-hand smoke (SHS) can be reduced. Smoke-free home interventions have largely targeted mothers who smoke, and there is little understanding of the barriers and facilitators that fathers experience in creating a smoke-free home. Systematic searches combining terms for fathers, homes, and SHS exposure were run in April 2019 in Web of Science’s Citation Indices, PsycINFO, and PubMed for English-language studies published since 2008. The searches identified 980 records for screening, plus 66 records from other sources. Twelve studies reported in 13 papers were included in this scoping review. Eight of the studies were conducted in Asian countries (five in China, one in India, one in Japan, and one in Iran), three were conducted in Canada, and one in Turkey. Findings were extracted in verbatim text for thematic analysis. The review identified that attitudes and knowledge, cultural and social norms, gender power relations, and shifting perceptions and responsibilities related to fatherhood can impact on fathers’ views of their role in relation to creating and maintaining a smoke-free home. There were too few published studies that had assessed smoke-free home interventions with fathers to draw conclusions regarding effective approaches. Research is clearly needed to inform our understanding of fathers’ roles, successes and challenges in creating and maintaining a smoke-free home, so that father-inclusive rather than mother-led interventions can be developed to benefit entire households and improve gender equity as well as health.
Spectral characterization of distributed Brillouin sensors in the transient regime
Creators: name: Ferrier, Graham Alan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Physics, Optics.

description: Brillouin scattering based fibre optic sensors have been actively researched over the past decade due to their enhanced sensitivity to environmental parameters such as temperature and strain. Applications range from dynamic health monitoring of civil structures such as bridges, pipelines, and nuclear reactors to real-time threshold applications such as fire detection. As temperature and strain changes often represent the first symptoms of structural degradation, the development of Brillouin scattering based technology will bear considerable scientific as well as economic benefit. Brillouin sensors employing the probe-pump amplification technique obtain distributed spatial information along a fibre using narrow pulses. In this study, the impact of pulse width and extinction ratio on the overall Brillouin spectrum shape is investigated. From independent theoretical and experimental investigations, a comprehensive curve fitting method is proposed to reveal the physical nature of Brillouin scattering in the transient regime.
Is distributed database evaluation cloud-ready?
Creators: name: Seybold, Daniel
name: Domaschka, Jörg
Publisher: name: Universität Ulm
Year: 2017
Subjects: subject: database evaluation
subject: DDC 004 / Data processing & computer science
subject: Distributed databases
subject: Database management; Evaluation
subject: Cloud computing
subject: Non-relational databases
subject: Cloud Computing
subject: NoSQL-Datenbanksystem
subject: Verteiltes Datenbanksystem
subject: Formative Evaluation

description: The database landscape has significantly evolved over the last decade as cloud computing enables to run distributed databases on virtually unlimited cloud resources. Hence, the already non-trivial task of selecting and deploying a distributed database system becomes more challenging. Database evaluation frameworks aim at easing this task by guiding the database selection and deployment decision. The evaluation of databases has evolved as well by moving the evaluation focus from performance to distribution aspects such as scalability and elasticity. This paper presents a cloud-centric analysis of distributed database evaluation frameworks based on evaluation tiers and framework requirements. It analysis eight well adopted evaluation frameworks. The results point out that the evaluation tiers performance, scalability, elasticity and consistency are well supported, in contrast to resource selection and availability. Further, the analysed frameworks do not support cloud-centric requirements but support classic evaluation requirements.
title: Pesticides in European rivers, lakes and groundwaters - data assessment
title: Pesticides in European rivers, lakes and groundwaters
titleType: AlternativeTitle
Creators: name: Mohaupt, Volker
name: Völker, Jeanette
name: Altenburger, Rolf
Publisher: name: My University
Year: 2020
Subjects: See [Binnengewässer]
Grundwasser
Schädlingsbekämpfungsmittel
Umweltstandard
Europa

description: Pesticides play an important role in the food production process, but they can also lead to harmful effects in the environment. This report provides an overview of the available information on pesticide concentrations in fresh waters and groundwaters in Europe. The report considers data comparable at European level, delivering a detailed summary of data reported to WISE-SoE by Eionet countries, for concentrations in rivers, lakes and groundwater between 2007 - 2017. This includes information on 180 substances, which were characterised according to usage, mode of action, environmental quality standards and analytical limits of quantification. Other data sources, like scientific research projects, special campaigns or emission data were found to be less useful for a Europe-wide assessment. For rivers and lakes over the period 2007 - 2017, between 5 - 15 % of the monitoring stations showed exceedances of environmental quality standards by herbicides and 3 - 8 % by insecticides. Exceedances in groundwater were 7 % for herbicides and less than 1 % for insecticides. Exceedances were assessed using European environmental quality standards where possible, but otherwise a precautionary approach was taken, using national standards. By comparison, percentages of water body status as reported under the Water Framework Directive (2010 - 2015) were similar for groundwater, but for surface waters only 0.4% were reported as failing good status. The data quality assurance and assessment methods provide a sound basis for further work to develop an indicator on pesticides in water. ©European Topic Centre on Inland, Coastal and Marine waters (ETC/ICM), 2020
L'esercizio dell'attività sindacale dei ministri di culto nella Chiesa ortodossa romena
Creators: name: Botti, Federica
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2012

description: Il contributo, sottoposto a valutazione, è destinato alla pubblicazione in una raccolta di saggi sui rapporti tra Stato e Confessioni religiose in Romania che apparirà nella Collana di Diritto Ecclesiastico Comparato e Diritti Umani diretta da G. Cimbalo e pubblicata dalla Bononia University Press di BolognaSOMMARIO: 1. Premessa – 2. La costituzione di organizzazioni sindacali di ministri di culto e laici appartenenti alla BOR - 3. Il riconoscimento della personalità giuridica civile al “Sindicatul Pǎstorul cel Bun”- 4. La questione davanti alla Corte EDU: la preminenza del diritto alla tutela attraverso l’azione sindacale - 5. La Corte EDU e l’esistenza di un “besoin social impérieux” - 6. La risposta della Chiesa ortodossa romena alla sentenza CEDU e l’appello alla Grand Chambre - 7. Alcune considerazioni conclusive
description: Stato, Chiese e pluralismo confessionale, 2012: 15 ottobre
Institutional Dynamics in Research. Processes of co-creation in Research Infrastructures.
Creators: name: Morselli, Francesca
Publisher: name: Zenodo
Year: 2020
Subjects: Research Infrastructures; collaboration; co-creation

description: Presentation of my PhD research at the workshop "Knowledge Infrastructures and Digital Governance. History, Challenges, Practices". on 07-08/ 09/2020.
Nuove leggi per vecchie intese
Creators: name: Canonico, Marco
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2012

description: Contributo sottoposto a valutazioneSOMMARIO: 1. L’insperato recupero di alcune intese - 2. Le novità degne di nota - 3. Osservazioni conclusive
description: Stato, Chiese e pluralismo confessionale, 2012: 15 ottobre
An Ensemble Empirical Mode Decomposition Approach to Wear Particle Detection in Lubricating Oil Subject to Particle Overlap
Creators: name: Li, Zhendan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: particle detection
EMD

description: With the development of mechanical fault diagnosis technology, complex mechanical systems do not need to be shut down periodically for the maintenance. The working condition of the mechanical systems can be monitored by analyzing the wear metal particles in the systems' lubricating oil. However, the output signals of the monitoring sensor are non-stationary. In some case the particle signals are overlapped with each other. The goal of this thesis is to find a method to decompose those overlapped particle signals, and then count the particle number in the lubricating oil. At the beginning EMD method was introduced in the experiment because of the character of the sensor signals. In this project, because EMD method is sensitive to the noise in the original signals, an improved version of EMD, EEMD method was implemented. Finally, a post processing method was used to get a better result.
La convivenza coniugale quale elemento ostativo alla delibazione della sentenza ecclesiastica di nullità matrimoniale alla luce delle recenti evoluzioni giurisprudenziali
Creators: name: Mioli, Graziano
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2012

description: Contributo sottoposto a valutazioneIl contenuto dei §§ 1-2-6, con alcune modifiche ed in versione ridotta nelle note, è destinato alla pubblicazione su Ius Ecclesiae come nota a sentenza di Cass., 4 giugno 2012, n. 8926SOMMARIO: 1. La critica della (non) critica della ragion giuridica – 2. Il riesame del merito: un pericolo incombente – 3. La rilevabilità d'ufficio delle questioni di contrarietà all'ordine pubblico – 4. Le inquietanti derive delle corti di merito – 5. Il riproporsi di una vexata quaestio, ossia il divieto di attività istruttoria – 6. Per una soluzione definitiva di una storia infinita
description: Stato, Chiese e pluralismo confessionale, 2012: 15 ottobre
Internationalisation activities and performance of Vietnam SMEs
Creators: name: Le, Viet
name: Harvi, Charles
Publisher: name: Swinburne
Year: 2024

description: Small and medium enterprises accounts for a majority of Vietnamese enterprises. They have made significant contributions to the economy of Vietnam by creating employment, income and economic growth. Increasingly, they also participate in internationalisation activities as Vietnam is furthering its integration to the global economy. This paper focuses on the impact of internationalisation activities and the performance of Vietnamese manufacturing SMEs. Specifically, it examines the impact of exporting, subcontracting and cooperation with a foreign partner on the technical efficiency of SMEs in the manufacturing sector and its subsectors from three surveys of domestic private SMEs in 2002, 2005 and 2007. Using a stochastic frontier production function model and a technical inefficiency effects model the paper found that there are limited benefits of these activities on the technical efficiency performance of manufacturing SMEs across different sub-sectors. Thus, the paper suggests SMEs to upgrade their technology and skills of their employees to become competitive and benefit from these internationalisation activities. In addition, it emphasises the need for the government to focus on encouraging SMEs in sub-sectors which are competitive in the international markets to pursue these activities and provide quality information to help domestic SMEs to identify the right partners from overseas.