cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Inhibition of Breast Cancer Aggressiveness by Cannabidiol
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: An anti-cancer agent with a low toxicity profile that can both inhibit cancer cell growth and metastasis would be extremely valuable clinically. We have discovered that cannabidiol (CBD), a non-psychotropic cannabinoid constituent of the plant Cannabis sativa, can inhibit the growth, migration and invasion of aggressive breast cancer cells in culture. Cannabinoid compounds, in general, have low toxicity profiles. Furthermore, our preliminary research demonstrated that CBD is a novel inhibitor of a protein whose activity has been closely linked to the aggressiveness of human breast cancers; called inhibitor of DNA binding-1 (Id-1). Whether CBD can inhibit the spread of metastatic breast cancer in vivo (in the body), compared to cell culture conditions, has not been determined. However, CBD has been demonstrated to inhibit aggressive human brain cancers in vivo. Understanding the mechanisms behind the anti-cancer activity of CBD may lead to the validation of new biological targets for diagnostics and therapies for breast cancer.

 To study the effects of CBD on the growth and spread of aggressive breast cancer, we will use time lapse microscopy to capture detailed changes in cell growth/death, migration, and morphology. Classical biochemical measures of cell growth/death and invasion will also be used in combination with novel compounds to identify receptors that CBD interacts with to produce its anti- breast cancer effects. A mouse model of breast cancer metastasis will be used to determine whether CBD effectively reduces the spread of aggressive breast cancer in vivo. At the intracellular level, we will study whether CBD, (1) regulates Id-1 in an extracellular signal-regulated kinase-dependent manner, and (2) serves to activate a pro-apoptotic (cell death) pathway in a caspase-dependent manner.

 Novel and effective non-toxic therapies for aggressive breast cancers are urgently required. Plant cannabinoids are compounds that are well tolerated during chronic (long-term) administration. CBD, and compounds based on its structure, may be the basis for the treatment of metastatic breast cancer. If successful, our studies will set the stage for additional translational work to develop CBD’s eligibility for clinical trials.
RAMANUJAN'S SUMMATION : WHICH  CONTRADICTS THE TRADITONAL SENSE
Creators: name: Mukherjee, Prahlad
Publisher: name: Zenodo
Year: 2021

description: Applied Mathematics & Theoritical  Physics are the most important things to study about the nature.”The beauty of Mathematics lies to solve all hidden secrets of our world”The summation of all natural numbers must ba a positive number but the topic of this project is how the value is (-1/12) which contradicts the traditional sense . In the other hand without this result the Earth can’t expand, the Casimir Force will not act . Even we can’t stand on the Earth surface  if the result is not equal to (-1/12)Application of this is indispensable for Space Science & Higher Mathematical Research . We can say that where there is application of physical significance of the world there is use of  1+2+3+….∞= (-1/12)
description: I have tried to link real & complex analysis through Beta-Gamma Function & also have shown how it's used in Bosonic String Theory & Casimir Effect.This was my undergraduate project in Suri Vidyasagar College affilated under The University of Burdwan
Fermi Assecuratori
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Livorno
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
CCR5 knockout HSC as an anti-HIV therapy
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: HIV infects cells by binding to two entry molecules, the CD4 protein and an additional co-receptor molecule such as CCR5. The finding that people with a genetic mutation that blocks the expression of CCR5 are naturally resistant to HIV has led to a great deal of interest in the development of therapies that could block the HIV-CCR5 interaction in patients, and several drugs that block CCR5 are now in development. We hypothesize that it may also be possible to engineer a patient’s own hematopoietic (blood) stem cells to prevent expression of the CCR5 gene, and that these stem cells would then be able to give rise to CCR5-negative progeny blood cells in a patient that would be resistant to HIV. In order to do this, we are working with a technology based on zinc finger nucleases that specifically target the CCR5 gene and cause a mutation at that site. The current proposal is aimed at maximizing the efficiency with which we can perform this CCR5 disruption event so that we can begin to test whether such engineered cells remain fully functional despite the loss of CCR5, and whether they can give rise to progeny cells that do not express CCR5 and are indeed resistant to HIV.
Finck, J. L
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Frankfurt a. M.
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Zygothrica oviserrata Grimaldi 1987
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Zygothrica
Zygothrica oviserrata

description: oviserrata Grimaldi, 1987: 160. Type locality: Colombia. NT Distr.: Colombia. Near Bogotá, Usme-El Hato Road. HT M (AMNH).
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 738, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Fehr, J. C
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: St. Gallen
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Forcart, Johann Conrad
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Lausanne
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Protein Engineering Aids Chimeric Antigen Receptor Design
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Chimeric antigen receptor (CAR) directed T-cell therapy has reenergized the cancer immunotherapy field with remarkable success treating patients with multiple types of leukemia and lymphoma in the clinic. Two such therapies, Kymriah and Yescarta, were recently approved by the FDA for widespread clinical use. On the heels of this success, the immunotherapy field has begun to apply this technology to treat many different types of cancers. The generation of new chimeric antigen receptors for these applications is empirical and inefficient, requiring low-throughput experiments to validate activity. Many of the potential pitfalls in this process stem from the molecular design of these CARs, which can lead to undesirable characteristics that decrease therapeutic impact. I am using engineering principles and high-throughput screening techniques to aid CAR design and rapidly screen hundreds of millions to billions of variant molecules capable of mediating T cell recognition for appropriate disease-specific interactions. Overall, this work will streamline the CAR development process through a suite of efficient techniques, as well as open new avenues for the development of novel CARs as additional immunotherapy targets in different cancers are discovered. Additionally, CARs developed through these projects will progress toward clinical translation, turning these fundamental scientific advances into technologies with a positive impact on patients and their families.
MRI Guided Focused Ultrasound in Breast Cancer Treatment
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Improved technologies for breast cancer screening have led to an increased detection of tumors that cannot be felt through palpation. Because these tumors are non-palpable, the current method to locate them for breast conservation surgery is image guided, single wire placement. However, wire localization lacks precision. It can result in positive tumor margins, which is the largest cause of local recurrence after breast conservation surgery, in 14-57% of patients. A new approach for pre-operative localization is to use MR-Image guided Focused Ultrasound (MR-FUS). By using a highly focused ultrasound beam, a small (2mm x 8mm) thermal hot spot kills cells deep within the body, while completely sparing healthy adjacent tissues. The mechanical properties of the tissue change due to heating, and can become stiffer. We hypothesize that the thermal lesions created by MR-FUS can precisely mark the perimeter non-palpable tumors, even irregularly shaped tumors, so that surgeons can feel where the tumor is during surgery.

 To further advance the MR-FUS approach, the present study will develop a MR Acoustic Radiation Force Imaging (MR-ARFI) sequence that uses non-thermal ultrasound pulses to displace tissue. The MR-ARFI sequence will be used to 1) calibrate the ultrasound focal spot location in the tissue and to 2) monitor the focal spot during the heating phase of ablation. It will also be used to measure changes in tissue displacement, which correlate to a change in tissue stiffness of the ablated lesions. Next, we will optimize the ultrasound parameters. Thermal lesions will be tested separately in various tissue types found in the breast: fatty, primarily fibroglandular, and heterogeneous spots with both fatty and fibroglandular components. Lastly, the MR-FUS method will be compared against the wire localization method. Non-palpable mock tumors with MR contrast agent will be injected into cadaver breasts. Half of the breast specimens will receive pre-operative image guided tumor localization using the wire localization technique, and the other half will be localized using the MR-FUS method. A trained breast surgeon will use the localization methods to excise the mock tumor from the breast. The results of each method will be compared by imaging the remaining breast tissue to evaluate tumor margins.

 This research is aimed to better breast conservation surgery with an image guided intervention. By changing the approach for breast conservation surgery, this project has the potential improve surgical outcomes, and to reduce the heavy patient burden of repeat surgeries.
Fellner, Constantin & Sohn
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Frankfurt a. M.
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Identification and characterization of critical laminin-111 sequences required for polymerization and cell surface anchorage and the requirement of both activities for proper basement membrane formation and other events
Creators: name: Harrison, David A.
Publisher: name: No Publisher Supplied
Year: 2012

description: A system was developed for expression and purification of various recombinant a1 LG4-5 and heterotrimeric laminin-111 proteins. A number of combinations involving different promoters, 5’UTRs, signal sequences, epitope tags, selectable antibiotics, and purification schemes were tested in order to optimize the system.  A homology model of laminin a1 LG4-5 was generated and utilized to identify candidates for mutation and expression as recombinant a1 LG4-5 proteins.  The crystal structure of a1 LG4-5 was also determined.  Heparin, a-dystroglycan (aDG), and sulfatide binding of the generated mutants demonstrated wide differences and dependence upon contributions from basic residues on the surface of LG4, including: RKR2721 and KRK2793 for heparin;  RAR2833, KDR2860, the Asn2811 glycation moiety, and the LG4 Ca2+ ion for aDG;  the LG4 Ca2+, Arg2833 of RAR2833, and Lys2766 residue of RKGRTK2770 for one sulfatide binding site, and the Arg2831 of RAR2833 for a second sulfatide site.   The produced recombinant heterotrimeric laminin-111s demonstrated a requirement for the N-terminal LN domains of laminin-111’s constituent a1, b1, and g1 chains in self-polymerization.  The inability of embryoid bodies, derived from laminin g1 null embryonic stem cells, to express Lm-111 and develop past formation of an outer endodermal layer of cells without laminin, was utilized via the addition of exogeneous recombinant laminin-111s, to test the various functions of the recombinant laminins and their ability to form a basement membrane and induce both differentiation of an epiblast layer and formation of a central cavity.  Laminins’ containing defective polymerization or a1 LG4 anchorage failed to form a BM or undergo any further development after endodermal differentiation.     Experiments with Schwann cells, C2C12 myotubes, and mouse embryonic fibroblasts demonstrated the requirement for both polymerization and a1 LG4 mediated anchorage in laminin-111 for proper BM formation, cytoskeletal attachment, and laminin induced cell signaling via Src.  The results also suggest a role for laminin-111 polymerization and anchorage in providing a means for aggregation and accumulation of low affinity interactions in a complex, thereby attaining very high net affinities for binding interactions and attaining otherwise unatainable thresholds necessary for these interactions to exert their effects through manipulation of the cytoskeleton, as well as, laminin induced differentiation and cell signaling.
Zygothrica panopia Grimaldi 1987
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Zygothrica
Zygothrica panopia

description: panopia Grimaldi, 1987: 264. Type locality: Panama, Chiriqui, El Volcán. HT M (USNM). NT Distr.: Bolivia to Costa Rica.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 738, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
RNA-guided genome engineering for HIV resistance
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The biggest obstacle in a cure for HIV/AIDS is the elimination of latently infected T-cells, in which the virus can remain dormant for years or even decades despite continuous antiretroviral therapy. It is well established that the vast majority, if not all, HIV-infected adults have a reservoir of latent virus that will likely persist the rest of their lives. In this research proposal, we aim to engineer a recently discovered biological process toward developing a novel therapeutic that may offer a curative strategy for HIV. This natural ‘gene editing’ process, referred to as CRISPR, exists in bacteria to cause DNA damage in harmful viruses that infect bacteria. This system uses a small RNA to recognize a specific viral DNA sequence, analogous to a ‘lock-and-key.’ We aim to harness the RNA-guided CRISPR technology for eradicating HIV latency and creating HIV-resistant cells. By engineering the CRISPR technology as a new anti-HIV therapeutic, we will target the HIV genes in latently infected cells, which is not achievable with current therapeutics. Moreover, this technology is easily adaptable for using multiple small RNAs that target different genes or even different DNA sequences within the same gene. Thus, using the same CRISPR system with different small RNAs, we will direct DNA damage in specific human genes that are necessary for HIV infection, but are not essential for normal cell health. One such gene is called CCR5. People with natural mutations in this gene have normal health, but they are also naturally resistant to HIV. Thus, we propose using the CRISPR technology to disrupt the CCR5 gene in hematopoietic stem cells, which could generate an immune system that is resistant to HIV infection. This concept is supported by the recent report of the famous ‘Berlin Patient,’ who was functionally cured of HIV after receiving a transplant of hematopoietic stem cells that contained natural mutations in the CCR5 gene. However, natural mutations within the CCR5 gene are extremely rare, so a technology that could specifically eliminate the CCR5 gene would vastly expand the number of HIV patients that could be functionally cured like the ‘Berlin Patient.’ In addition to CCR5, we propose a similar CRISPR strategy to remove the human CXCR4 gene in T-cells. Like CCR5, CXCR4 is human co-receptor used during HIV infection. Therefore, we propose using the same RNA-guided CRISPR technology to eliminate latent HIV infections and to create HIV-resistant cells.
Fioretti, Gaspare
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Brescia
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Feuer-Versicherungs-Anstalt
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Leipzig
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Identification of the cellular target of Vpu
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: HIV expresses four so-called ‘accessory’ proteins, whose activity is vital for the development of AIDS. One of these proteins, the Vpu protein, strongly stimulates the production of new virus particles from an infected cell. However the mechanism whereby it does this is unknown, and represents a significant gap in our understanding of HIV biology. We have been investigating the ability of Vpu to enhance virus production from a variety of cell types and have made interesting preliminary discoveries that we wish to follow up on. First, we have shown that the generally accepted view that the membrane-spanning region of Vpu contains the virus enhancing activity is incomplete, as the cytoplasmic tail of the protein is also essential for this activity. Several interesting signals are present in this region of the protein and by studying their role in Vpu activity we expect to gain a better understanding of how Vpu works. Second, we have identified a mutant cell line which has lost the ability to support Vpu activity. By studying the differences between this cell line and normal cells, we hope to uncover the defect in the non-responsive cells and thereby gain insight into the host cell machinery that Vpu interacts with in order to promote virus production. Such information would open up a new area of HIV research and could lead to the development of novel anti-HIV drugs.
Flersheim, Salomon, & Co
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Frankfurt a. M.
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Breast Cancer Neoadjuvant Chemotherapy Response with miRNA
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Pre-operative chemotherapy, also referred to as neoadjuvant chemotherapy (NCT), is increasingly being used to treat patients with late-stage breast cancers, with the expectation that the treatment can reduce the size or extent of the cancer before surgery, thus making the surgical procedures easier and more likely to be successful. However, only a minority of the patients who have receive NCT show optimal response. The underlying reasons remain unclear; therefore, it is critical to develop clinical markers to better predict patients’ NCT response and to determine the causes of drug resistance at the molecular level.

 This project focuses on the detection of a novel type of biomarker, microRNAs (miRNAs), from the blood of breast cancer patients. These, recently discovered, small molecules play crucial functions in various physiological mechanisms and are aberrantly expressed in cancer. MiRNAs can be secreted by cancer cells and readily detected from blood, since they are so stable. Our project is a study to assess circulating miRNAs in breast cancer patients, and on their correlation with tumor NCT response.

 Our approach, first, is to collect RNA fractions enriched for small RNAs from paired breast cancer tissue and serum samples prior to and after NCT. These samples will be analyzed by “deep sequencing” (i.e., DNA sequencing at very high throughput) with the Solexa platform. We will characterize changes in the miRNA profiles after NCT, and will identify miRNA signatures associated with drug response and resistance. In parallel, growth media will be prepared from a panel of breast cancer cell lines and normal cells cultured in the presence/absence of the chemotherapy agent cisplatin. Deep sequencing analyses will be carried out and the profiles of miRNAs secreted by cancer and normal cells. Secreted miRNAs with cancer specificity and correlated to clinical features, and those for which level is changed upon drug treatment will be validated and selected for additional study. Taken together, we hope to relate the changes in the miRNA “signature” to clinically-relevant mechanistic/ molecular-level changes that predict a patients’ successful NCT response.

 Identification of blood-based miRNA “signature” that predicts response to NCT, as an immediate outcome of this study, will enhance our ability to develop individualized NCT, which will result in higher drug efficacy with reduced side effects. This study may also reveal novel mechanisms of drug action/resistance.
Verwaltungsrat Protokolle 9
Creators: name: Chemische Fabrik Uetikon
Publisher: name: [s.n.]
Year: 1969

description: Deutsch
description: Verzeichnung=Description=Inventaire 18.10.2023 Automatisierter Import Archivbestand
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Verwaltungsrat Protokolle 8
Creators: name: Chemische Fabrik Uetikon
Publisher: name: [s.n.]
Year: 1966

description: Deutsch
description: Verzeichnung=Description=Inventaire 18.10.2023 Automatisierter Import Archivbestand
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
title: Interested in Peer Reviewing? Let’s Talk
Creators: name: Raboin, Regina
Publisher: name: eScholarship@UMassChan
Year: 2022

description: What does good peer review mean in the context of scholarly publishing? How can I be an effective peer reviewer? If I’ve never done it before, where would I start? Regina Raboin, Editor-In-Chief of the Journal of eScience Librarianship, will de-mystify peer review and answer your questions about this important process. In this presentation, both new and experienced peer reviewers can learn how to sharpen their skills and contribute to excellent scholarly communication.
Henderson, Katherine D.
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: While breast cancer mortality has been steadily decreasing since 1990, this decline has not been realized equally among all racial/ethnic groups in the U.S. For example, from 1995-2004, SEER data indicates a 2.4% yearly decrease in mortality for white and Hispanic/Latina women, but only a 1.6% yearly decrease for African Americans. Although rates are decreasing over time among both African Americans and whites, the rate among whites is decreasing faster, so the net effect has been a widening disparity in breast cancer mortality. While differences in stage at diagnosis are important in understanding these survival disparities, even when stage is controlled for, a persistent and growing survival disparity emerges. The reasons for this are not clear.

 Among other racial/ethnic groups even less is known about the factors affecting survival rates. Attempts to fill this knowledge gap are hindered because specific racial/ethnic subgroups are often aggregated to achieve sufficient numbers in studies, but this procedure may be obscuring important trends and factors specific to certain subgroups.

 The cohort and case-control studies overcome this problem by collecting detailed information on each individual through the use of a variety of survey instruments and often blood and/or fluid sampling. However, existing California cohort and case-control studies do not have sufficient numbers of different racial and ethnic populations to allow inter-group comparisons.

 Representatives of the California Teachers Study and other studies are collaborating to determine whether it is feasible to pool data from our existing California case-control and cohort studies to investigate critical issue(s) in stage-specific survival that could not be answered by any of the studies alone. This feasibility study will review and evaluate:

 1. The comparability of survey instruments

 2. The compatibility of data sets (platforms, variables, etc.),

 3. The quality and type(s) of additional data that could be linked to data from study participants (e.g. records from medical databases).

 4. The specific research question(s) not answered by the individual studies that could be answered by pooling data from these studies.

 The proposed goal of this study is a full research proposal to investigate unique questions about disparities and breast cancer survival in California.
Verwaltungsrat Protokolle 7
Creators: name: Chemische Fabrik Uetikon
Publisher: name: [s.n.]
Year: 1964

description: Deutsch
description: Verzeichnung=Description=Inventaire 18.10.2023 Automatisierter Import Archivbestand
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Drosophila pictura Grimaldi 1987
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila pictura

description: pictura Grimaldi, 1987: 187. Type locality: Colombia, Amazonas, Leticia. HT M (AMNH) NT Distr.: Colombia.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 738, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Inducible expression of siRNAs to inhibit HIV replication
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Gene therapy strategies using genetically modified T cells or blood stem cells have been proposed as an adjuvant to chemotherapy for treating HIV infection. RNA interference (RNAi) is a gene expression-silencing mechanism in which small interfering 21- to 23-mer double-stranded RNA (siRNA) pairs with the target mRNA and mediates sequence-specific degradation of the mRNA. The discovery that exogenously delivered siRNA can lead to mRNA degradation in mammalian cells raises the possibility of using the RNAi technology as a therapeutic tool to down-regulate HIV mRNAs and inhibit its infection. However, expression of a single siRNA frequently leads to the emergence of HIV escape mutants resistant to the siRNA. Sequence analysis of these mutants reveals that the siRNA target sites have nucleotide substitutions or deletions. The rapid replication kinetics of HIV-1 and the error-prone nature of virus replication most likely lead to the emergence and selection of virus mutants with changes in the siRNA target site, thereby abolishing the siRNA antiviral effect. Thus, similar to antiviral drug therapy paradigms, multiple siRNAs targeting to different regions of the HIV-1 genome need to be developed to reduce the probability of generating resistant mutants. The other problem is that stable expression of anti-HIV siRNAs in cells can cause undesirable side effects to the cells, including a block in RNAi machinery normally operating in the cell. Moreover, an “off-target” effect caused by partial pairing between a siRNA and a host mRNA may also alter host cell gene expression non-specifically. These problems can be partially solved by designing siRNAs targeting to multiple sites in the HIV genome and by using an inducible promoter to control the siRNA gene expression. We propose to evaluate two specific promoters: the interleukin-2 promoter and the HIV promoter for their ability to regulate siRNA expression. Both promoters have relatively low basal activity without stimulation but can be strongly activated by HIV infection. We will place siRNA genes specifically to HIV gag, tat/rev and HIV co-receptor CCR5 genes under the control of the inducible promoter and deliver the expression cassette into human blood-derived cells. The inducible expression of these siRNA genes and their anti-HIV efficacy will be evaluated by infecting these cells with HIV-1 and monitored by HIV production from the infected cells.
Verwaltungsrat Protokolle 6
Creators: name: Chemische Fabrik Uetikon
Publisher: name: [s.n.]
Year: 1961

description: Deutsch
description: Verzeichnung=Description=Inventaire 18.10.2023 Automatisierter Import Archivbestand
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
The efficacy of the Association of Art Museum Directors’ online antiquities registry
Creators: name: Hagen, Alyssa Cathleen
Publisher: name: No Publisher Supplied
Year: 2012

description: High-profile international legal suits and the gradual establishment of legal precedence for repatriation cases in the U.S. under the National Stolen Property Act and the Cultural Property Implementation Act of 1983 have coincided with the Association of Art Museum Directors (AAMD) adopting codes of ethics and recommended guidelines for member museum acquisitions. When the AAMD Subcommittee on the Acquisition of Archaeological Materials and Ancient Art issued its 2008 report, it established the online Registry of New Acquisitions of Archaeological Material and Works of Ancient Art to help member museums efficiently disseminate information about recent acquisitions with incomplete provenance. This is the first systematic analysis of its contents. Using data from 325 listings (as of January 2012) by eleven participating institutions, this paper argues that museums are not sufficiently vigilant about following the AAMD's 2008 guidelines.
Machine made
Creators: name: Golway, Terrence
Publisher: name: No Publisher Supplied
Year: 2012

description: Although Tammany Hall was founded as a social club just after the American Revolution, it exists in memory as the quintessential American political machine, run by and for Irish-American political operatives more concerned with power than ideas. This dissertation seeks to re-interpret Tammany in the context of a transatlantic Irish experience of hunger, dislocation, and alienation. Irish immigrants brought with them distinct political narratives which were incorporated into Tammany Hall’s pragmatic but progressive ideology during the first quarter of the 20th Century.  These political narratives, centered on the experience of powerlessness and oppression in Ireland and inextricably linked to Catholicism, led Irish immigrants to regard reformers in New York as American versions of their traditional enemies, the well-born Anglo-Protestant.     The Irish arrived in New York with an understanding of the power of mass politics thanks to Daniel O’Connell’s campaign for Catholic Emancipation in the 1820s. Few studies of Tammany Hall attempt to link O’Connell’s mobilization of the Irish peasantry to Tammany’s ability to turn out the vote, especially after the Famine exodus of 1845-52.     Likewise, the critical role of John Hughes, the first Catholic archbishop of New York and a native of Ireland, remains outside the story of Irish-American politics, despite the key role he played in organizing the Irish vote behind transatlantic grievances.     This dissertation seeks to show how a particularly Irish experience in both Ireland and New York helped to mobilize a new kind of politics which emphasized cultural pluralism, populist rhetoric, and practical solutions to social injustice. A child of a Famine immigrant, Charles Francis Murphy, transformed Tammany into a force for social change during the Progressive Era. Murphy’s forgotten role in nurturing politicians such as Alfred E. Smith and Robert Wagner has been forgotten, but this dissertation will show that his embrace of change helped set the stage for the rise of Franklin Roosevelt and the implementation of the New Deal.
Zygothrica posthona Grimaldi 1987
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Zygothrica
Zygothrica posthona

description: posthona Grimaldi, 1987: 256. Type locality: Bolivia, El Beni S. Inicua, Alto Beni River, 1100 m. HT M (CNC). NT Distr.: Colombia to Bolivia.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 738, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Sexual Health Communication: Young Gay Men and Their Friends
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: It is crucial to prevent the further transmission of HIV infection among young gay men (YGM). One way to reduce behaviors that may transmit HIV among YGM is to foster strong sexual communication skills with their sexual partners. However, little is known about the content and quality of sexual health communication between YGM and their friends. Friendships with other YGM and heterosexual females are particularly important sources of support for YGM. Thus, we propose to explore how sexual health communication between YGM and their best gay male and best heterosexual female friends may be related to healthier sexual lives among the YGM. This proposal is guided by the theories of planned behavior and sexual scripts. We plan to conduct in-depth, semi-structured interviews with 24 dyads (12 gay male dyads and 12 gay male/heterosexual female dyads). Participants for the study will be recruited at gay venues and invited to participate in a series of interviews: first as a dyad and second, individually. Participants will complete a brief quantitative survey. The findings from this study will have important implications, not only for YGM in Los Angeles, but also among similar populations at risk for HIV infection in California and nationally. We will use the findings to: inform an HIV prevention intervention that targets friendship dyads; learn about the topics of sexual health communication that YGM discuss with their best gay male and heterosexual female friends; and assess receptivity to HIV intervention topics and formats among YGM and their best friends.
Improving physical performance
Creators: name: Golem, Devon
Publisher: name: No Publisher Supplied
Year: 2012

description: Advances in mouthguard design applied the dental technique of jaw-repositioning to not only prevent negative effects but to enhance athletic performance.  Improved posture and proprioception have been observed with use of jaw-repositioning appliances (1-4).   In a previous study, a jaw-repositioning mouthguard improved muscular power in athletes (5). We compared a neuromuscular dentistry-designed jaw-repositioning mouthguard to a standard mouthguard in a randomized, crossover study evaluating muscular endurance and anaerobic capacity in male athletes.  The advanced jaw-repositioning mouthguard led to improved muscular power performance (6).  Although effective, the neuromuscular dentistry-designed mouthguard was highly expensive causing it to be impractical for the typical athlete.  The next two studies utilized affordable versions of the above mouthguard to expand the practical application of the findings.   We evaluated the effects of two jaw-repositioning mouthguards on other aspects of physical performance including balance, flexibility, agility, power and strength in male athletes.  A battery of exercise tests was completed in a randomized, controlled, crossover study.  No significant differences between the jaw-repositioning mouthguards, the placebo mouthguard, and the no-mouthguard control were observed in these aspects of physical performance.    Our final study evaluated the effects of two jaw-repositioning mouthguards on aerobic performance.  Jaw-repositioning devices treat sleep apnea by increasing the size of upper respiratory airways (7-11).  Jaw-repositioning mouthguards may have similar effects on the airways in athletes lending to improved aerobic performance.  The effects of two jaw-repositioning mouthguards on aerobic dynamics at rest and during a graded treadmill test in male athletes were evaluated.  No significant differences between the jaw-repositioning mouthguards and the controls were observed in respiratory functional tests, ventilation, gas exchange, or maximal aerobic performance.     These results indicate that the affordable jaw-repositioning mouthguards did not have any effect, positive or negative, on various performance aspects.  This information can be used to encourage mouthguard compliance and dissuade the concerns of performance impediments.  Incorporation of advanced dental techniques and individualized design may be necessary to obtain an “optimal jaw position” that promotes positive physical responses.  Future research on jaw-repositioning mouthguards should use advanced dental techniques and explore effects on other aspects of physical performance.
Drosophila prodispar Duda 1927
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila prodispar

description: prodispar Duda, 1927: 63. Type locality: Peru, Pinipini. HT M (SMT). NT Distr.: Mexico to Brazil and Peru. Refs.: Grimaldi, 1987.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 738, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Zygothrica zygia Grimaldi 1987
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Zygothrica
Zygothrica zygia

description: zygia Grimaldi, 1987: 209. Type locality: Trinidad & Tobago, Tabaquite, Charuma Forest. HT M (USNM). NT Distr.: Trinidad to Peru.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 738, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Risk factors and prevention of cardiovascular disease among Asian-Indian men in a U.S. managed care organization
Creators: name: Ghai, Nirupa Rajendra
Publisher: name: No Publisher Supplied
Year: 2012

description: Researchers have reported higher rates of cardiovascular disease (CVD) clinical risk factors including diabetes mellitus (DM), hypertension, and dyslipidemia in Asian-Indians.  We sought to examine lifestyle/behavioral CVD risk factors overall and by vegetarian/non-vegetarian status, as well as CVD clinical risk factors in Asian-Indian men compared to white non-Hispanic men (WNH).  Eligible men were recruited from Kaiser Permanente Southern and Northern California into the California Men’s Health Study (CMHS) Cohort between 2002-2003.  Asian-Indians more often reported a healthy BMI (18.5-24.9), and consumed <30% calories from fat compared to WNHs.  Among healthy weight men, Asian-Indians were less likely to eat 5 or more fruit and vegetables a day.  Overall, Asian-Indians were more likely to have never smoked and to abstain from alcohol.  Asian-Indians were less likely to report moderate/vigorous physical activity > 3.5 hours/week.    Vegetarians more often consumed a lower fat diet compared to non-vegetarians [Adjusted Odds Ratio (AOR) = 3.22; (95% Confidence Interval) (95% CI) 2.80-3.71].  Vegetarians reported consuming more fruits and vegetables; however a statistically significant difference was not detected among Asian-Indians.  Further, WNH vegetarians reported less sedentary activity [AOR = 0.65; 95% CI 0.54-0.78] and more moderate/vigorous physical activity [AOR = 1.87; 95% CI 1.55-2.25] than WNH non-vegetarians, however this was not the case among Asian-Indians.    We found Asian-Indians had higher rates of DM and dyslipidemia compared to WNHs.  Asian-Indians more often had lower mean systolic, diastolic and low-density lipoprotein (LDL) levels compared to WNHs.  Although control of hypertension and dyslipidemia was similar in the two populations, overall only 50% of men had LDL and triglyceride levels under the target values for control.    Our examination of lifestyle related CVD risk factors found evidence for both potentially protective and harmful health behaviors among Asian-Indian men.  Overall, we found that WNH vegetarians lead a healthier lifestyle (consuming lower fat diets and more fruits and vegetables, and participating in more physical activity and less sedentary behaviors) compared to non-vegetarians.  Finally, our examination of clinical CVD risk factors found evidence for increased clinical risk factors (DM and dyslipidemia) and clustering of clinical risk factors for CVD among Asian-Indians.
Patient and Clinician Knowledge of Breast Cancer Lymphedema
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Many women diagnosed with breast cancer can expect survival that is similar to cancer-free women of the same age due to advances in early detection and effective adjuvant therapies. Thus, quality of survivorship is becoming increasingly important. One potential complication during the survivorship period is breast cancer-related lymphedema (BCRL), a chronic condition characterized by irregular swelling of the arm, hand, and/or chest. Thus far, survivors have voiced dissatisfaction regarding their education on BCRL risk and being informed about BCRL risk reduction strategies from their healthcare providers. Therefore, an important need exists to better educate patients as well as clinicians about BCRL.

 The breast cancer-specific lymphedema topics to be addressed by this research include:

 1) the level of knowledge of BCRL among primary care physicians and NPs (nurse practitioners) compared to oncologists (medical and radiation) and surgeons (general and plastic)

 2) the relationship between misconceptions about the incidence and availability of treatment of BCRL between oncologists and surgeons

 3) overall knowledge of BCRL among patients by age at breast cancer diagnosis and race/ethnicity.

 4) follow-up referral rate differences for women diagnosed by their primary care physician or NPs.

 For these studies we will use data from a large HMO setting (Kaiser Permanente of Northern California (KPNC) Medical Care Program). We will evaluate the clinical management of BCRL from both the clinician and patient perspective by: (1) conducting a 10-minute web survey asking about knowledge of BCRL and associated referral patterns among 2,575 primary care physicians and 337 NPs, 111 oncologists, and 238 surgeons; and (2) administering a 20-minute telephone survey asking about knowledge and referral experience of BCRL among 400 breast cancer patients diagnosed with BCRL. In addition, we will collaborate with the National Lymphoma Network (Oakland, CA) to develop and pilot test our data collection instruments and protocols, and they will assist us in the dissemination of study results.

 BCRL is a chronic condition that can occur in up to 56% of breast cancer survivors weeks to years following treatment. Considering the above research context, our study will contribute to reducing the number of women with BCRL who go undetected and untreated in a large HMO setting.