cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Environmental DNA-based monitoring of the fish ladder in Dessau-Roßlau
Creators: name: Arle, Jens
name: Macher, Till-Hendrik
name: Schütz, Robin
name: Koschorreck, Jan
name: Beermann, Arne J.
name: Leese, Florian
name: Wagner, Falko
Publisher: name: My University
Year: 2023

description: Fast, reliable, comprehensive, and cost-efficient biodiversity data are needed for environmental assessment and decision making in water management. In this study, we investigated whether eDNA metabarcoding approaches can fulfil these requirements for fish monitoring. We collected 18 water samples of 1 l along a 2 km stretch of the river Mulde (Germany) on a single day in April 2019, in parallel with comprehensive fisheries monitoring conducted over 17 weeks at the fish ladder in Dessau-Roßlau. Additionally, data from Water Framework Directive (WFD) fish monitoring for the years 2017-19 of the same site were available. A total of 33 fish species were detected with all three sampling strategies. The highest number of species was detected with eDNA metabarcoding (28 species), followed by the fish ladder monitoring (27) and the WFD monitoring (22). In direct comparison with the eDNA-based approach, the fish ladder assessment had a higher overlap of detected species (23 of 32 species detected by both methods) than with the WFD monitoring data (19 of 31). While eDNA-based methods are currently limited to assessing species composition, data on abundance and even age composition could also be generated in future. Here, the smart combination of fisheries-based methods with a high spatial and temporal resolution of eDNA metabarcoding can contribute to a better understanding of changes in the ecosystem and thus improve water management. © 2023, Springer Fachmedien Wiesbaden GmbH, ein Teil von Springer Nature.
Forging New Ground: Creative civil society engagement of government to achieve rights-based policy change on immigration detention
Creators: name: Mitchell, Grant
Publisher: name: Swinburne
Year: 2024

description: This research examines the processes by which civil society has engaged governments to achieve rights-based policy change on immigration detention to inform human rights advocacy practices. Data was gathered from observations of meetings, interviews with policy makers and civil society groups in 16 countries, as well as the researcher’s experience as a participant working in the field. The research found a range of mechanisms that enhanced dialogue between civil society and government to bring about rights-based change in policies regarding immigration detention. Results will inform strategies for engagement between civil society and government on human rights issues.
Transcendance et technique chez Gabriel Marcel: Contribution a une éthique chrétienne
Creators: name: Poitras, François
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Theology.

description: Cette thèse de théologie veut étudier le lien entre la transcendance et la technique dans la pensée de Gabriel Marcel afin d'apporter une contribution a l'éthique chrétienne. En effet, à une époque ou l'omniprésence de la technique et de la science influence d'une manière significative la vie en société, il n'est pas surprenant que cela ait suscité de nombreuses réflexions de la part de philosophes au XXe siècle. Gabriel Marcel fait partie de ceux qui se sont penchés sur cette question. Sa réflexion porte moins sur la technique comme telle, que sur ses répercussions sur les relations entre les êtres humains. À cette dimension que nous pouvons appeler horizontale, s'ajoute une dimension verticale qui est la transcendance entendue comme une réalité qui fonde notre existence et lui confère un sens. Ultimement, cette transcendance se nomme Dieu. De prime abord, le lien entre la transcendance et la technique n'apparaît pas évident. Cependant, Gabriel Marcel nous montre qu'il ne faut pas en rester à cette première impression. Bien qu'il reconnaisse que les progrès techniques apportent leur lot de bienfaits indéniables à la société humaine, il n'en a pas moins dénoncé les graves dérivés. Pour Gabriel Marcel, la déshumanisation des relations humaines par la technique provient de sa mauvaise utilisation. Plus profondément, elle tient à la façon dont l'homme se situe dans l'existence et du sens qu'il peut y trouver. Si l'homme se ferme à une réalité qui fonde son être et lui donne son sens, il risque de se refermer sur lui-même et de se considérer comme le seul point de référence de ses projets et de ses actes. Dans cette optique, le recours à Carl Mitcham nous aidera à préciser certaines questions au sujet de la technique. Par exemple: en sont les intentions? Quels en sont les enjeux? (Abstract shortened by UMI.)
Supplementary document for filter construction using Ronchi masks and Legendre polynomials to analyze the noise in aberrations applying the irradiance transport equation - 4661363.pdf
Creators: name: Hernández, Jesús Arriaga
name: Otahola, Bolivia
name: Oliveros, Jose
name: Jaramillo-Núñez, Alberto
name: Castillo, María Morín
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized
Image Processing
Optical Physics not elsewhere classified

description: Supplemental material
title: Particle mass concentrations and number size distributions in 40 Homes in Germany: Indoor-to-outdoor relationships, diurnal and seasonal variation
title: Particle mass concentrations and number size distributions in 40 Homes in Germany: Indoor-to-outdoor relationships, diurnal and seasonal variation
titleType: AlternativeTitle
Creators: name: Birmili, Wolfram
name: Zhao, Jiangyue
name: Daniels, Anja
name: Wehner, Birgit
Publisher: name: My University
Year: 2020
Subjects: Innenraumluft
Europa

description: Few studies investigated residential particle concentration levels with a full picture of aerosol particles from 10 nm to 10 Ìm size range with size-resolved information, and none was performed in central Europe in the long-term in multiple homes. To capture representative diurnal and seasonal patterns of exposure to particles, and investigate the driving factors to their variations, measurements were performed in 40 homes for around two weeks each in Leipzig and Berlin, Germany. These over 500 days' measurements combined PM10 and PM2.5 mass concentrations, particle number concentration and size distribution (PNC and PNSD, 10-800 nm), CO2 concentration, and residential activities diary into a unique dataset. Natural ventilation was dominated, the mean ventilation rate calculated from CO2 measurements was 0.2 h-1 and 3.7 h-1 with closed and opened windows, respectively. The main findings of this study showed that, the residents in German homes were exposed to a significantly higher mass concentration of coarse particles than outdoors, thus indoor exposure to coarse particles cannot be described by outdoors. The median indoor PNC diurnal cycles were generally lower than outdoors (median I/O ratio 0.69). However, indoor exposure to particles was different in the cold and warm season. In the warm season, due to longer opening window periods, indoor sources' contribution was weakened, which also resulted in the indoor PNC and PNSD being very similar to the outdoors. In the cold season, indoor sources caused strong peaks of indoor PNC that exceeded outdoors, along with the relatively low penetration factor - 0.5 for all size ranges, and indoor particle losses, which was particularly effective in reducing the ultrafine PNC, resulting in a different particle exposure load than outdoors. This study provides a detailed understanding of residential particle exposure in multiple homes, facilitating future studies to assess health effects in residential environments. Quelle. https://aaqr.org/
Credibly conveyed and genuinely received: Reconciliation and the South African TRC revisited
Creators: name: Earl, Derek J. R
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Political Science, International Law and Relations.

description: This thesis revisits the South African Truth and Reconciliation Commission (TRC) to explore societal-level reconciliation viewed as the reconstruction of identity. It argues that narrative processes of identity construction can contribute in a positive way to reconciliation when a message of reconciliation is credibly conveyed and genuinely received. This means that a message of reconciliation is communicated, that the content of the message responds to the needs of the socio-cultural context, and that the message has been understood and accepted. The TRC message of reconciliation is embodied in themes of human rights, forgiveness, and ubuntu which offer a vision to a peaceful, inclusive South Africa. The conclusions reached suggest some positive indicators of a developing process of reconciliation, but the long-term success of the construction of a peaceful, democratic, and inclusive South Africa will also be a function of success in the political and socio-economic sectors.
Can TROPOMI-NO2 satellite data be used to track the drop and resurgence of NOx emissions between 2019-2021 using the multi-source plume method (MSPM)?
Creators: name: Dammers, Enrico
name: Tokaya, Janot
name: Mielke, Christian
name: Hausmann, Kevin
Publisher: name: My University
Year: 2022

description: Nitrogen dioxide (NOx) is an important primary air pollutant, dominantly produced by anthropogenic, mostly combustion based, activities from sectors such as industry, traffic and transport. NOx is directly linked to negative health and environmental impacts. Currently, the construction of emission inventories to keep track of NOx emissions is based on official national reported emissions and proxies such as activity data as well as direct measurements. The effort to properly construct an accurate inventory is significant and time consuming which causes a reporting offset between one and five years with respect to the current date. Next to this temporal lag difficulties in composed inventories can arise from legislative and protocol differences between countries and over time in reporting of emissions. Satellite based atmospheric composition measurements provide a unique opportunity to fill this gap and independently estimate emissions on a large scale in a consistent, transparent and comprehensible way. They give the possibility to check for compliance with emission reduction targets in a timely manner as well as to observe rapid emission reductions such as experienced during the COVID-19 lock-downs. In this study we apply a consistent methodology to derive NOx emissions over Germany for the years of 2019-2021. For the years where reporting is available differences between satellite estimates and inventory totals were within 100 kt. The large reduction of NOx emissions related to the COVID-19 lock-downs were observed in both the inventory and satellite derived emissions. The recent projections for the inventory emissions pointed to a recovery of the emissions towards pre-COVID19 levels this increase was not observed. While emissions from the larger power-plants did rebound to earlier levels, others sectors such as road transport and shipping did not and could be linked to a reduction in the number of heavier transport trucks. This again illustrates the value of having a consistent satellite based methodology for faster projections to guide and check the conventional emission inventory reporting. The method described in this manuscript also meet the demand for independent verification of the official emission inventories, which will enable inventory compilers to detect potentially problematic reporting issues. Transparency and comparability, two key values for emission reporting, are thus bolstered by this technique. © Author(s) 2022
Pathological and genetic analysis of host susceptibility to cardiovirulent coxsackievirus B3 infection in mice
Creators: name: Lejmi Mrad, Rim
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Biology, Genetics.
subject: Biology, Animal Physiology.

description: Nearly fifty percent of North American myocarditis cases are associated to coxsackievirus group B, type 3 (CVB3) infection. CVB3 infection of mice provides a useful model to study pathogenic mechanism of myocarditis. The objective of this study is to test the hypothesis that susceptibility, during the acute CVB3 infection, is under polygenic control including H2 as well as the non H-2 genes. To identify differential parameters of the disease, and if they are influenced by the H-2 haplotype, several phenotypic traits were characterized. Three inbred strains of mice and two congenic strains were infected with CVB3. Differences in survival, body weight loss, quantification of myocarditis and quantification of sarcolemmal disruption were found by comparing three sets of mice sharing the same H-2 haplotype but not the same background. It was determined that host susceptibility to CVB3-induced myocarditis is mainly controlled by "background" genes. Moreover, because there is a naturally occurring variability among inbred mice, ten inbred strains of mice were used for the genetic analysis of four CVB3-induced phenotypes: survival, body weight loss, heart viral load and quantification of sarcolemmal disruption. It was concluded that the strains could be divided into three groups: the highly resistant, the resistant to intermediate strains and the highly susceptible strains. This phenotypic data on commonly used and genetically diverse inbred mouse strains sets up the platform for a detailed analysis of the genetic basis of susceptibility to CVB3.
Serum levels of leptin and high molecular weight adiponectin are inversely associated with radiographic spinal progression in patients with ankylosing spondylitis: results from the ENRADAS trial
Creators: name: Hartl, Agnes
name: Sieper, Joachim
name: Syrbe, Uta
name: Listing, Joachim
name: Hermann, Kay-Geert
name: Rudwaleit, Martin
name: Poddubnyy, Denis
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Axial spondyloarthritis
subject: Ankylosing spondylitis
subject: Leptin
subject: Adiponectin
subject: Adipokine
subject: Radiographic progression
subject: Syndesmophytes
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Previous research indicates a role of adipokines in inflammation and osteogenesis. Hence adipokines might also have a pathophysiological role in inflammation and new bone formation in patients with ankylosing spondylitis (AS). The aim of this study was to investigate the role of adipokine serum levels as predictors of radiographic spinal progression in patients with AS. Methods A total of 120 patients with definite AS who completed a 2-year follow up in the ENRADAS trial were included in the current study. Radiographic spinal progression was defined as: (1) worsening of the modified Stoke Ankylosing Spondylitis spine (mSASSS) score by ≥2 points and/or (2) new syndesmophyte formation or progression of existing syndesmophytes after 2 years. Serum levels of adipokines (adiponectin (APN) and its high molecular weight form (HMW-APN), chemerin, leptin, lipocalin-2, omentin, resistin, visfatin) were measured using enzyme-linked immunosorbent assays. Results There was a significant association between radiographic spinal progression and both leptin and HMW-APN. Baseline serum levels of both adipokines were lower in patients who showed radiographic spinal progression after 2 years. This association was especially evident in men; they had generally lower leptin and HMW-APN serum levels as compared to women. The inverse association between adipokines and radiographic spinal progression was confirmed in the logistic regression analysis: the odds ratios (OR) for the outcome “no mSASSS progression ≥2 points” were 1.16 (95% CI 1.03 to 1.29) and 1.17 (95% CI 0.99 to 1.38), for leptin and HMW-APN, respectively; for “no syndesmophyte formation/progression” the respective OR were 1.29 (95% CI 1.11 to 1.50) and 1.18 (95% CI 0.98 to 1.42), adjusted for the presence of syndesmophytes at baseline, C-reactive protein at baseline, sex, body mass index (BMI), non- steroidal anti-inflammatory drugs intake score over 2 years, and smoking status at baseline. Conclusion Serum leptin and HMW-APN predict protection from spinal radiographic progression in patients with AS. Women generally have higher leptin and HMW-APN serum levels that might explain why they have less structural damage in the spine as compared to male patients with AS. Trial registration EudraCT: 2007-007637-39. ClinicalTrials.gov, NCT00715091. Registered on 14 July 2008.
Is Heightened-Shoaling a Good Candidate for Positive Emotional Behavior in Zebrafish?
Creators: name: Franks, Becca
name: Graham, Courtney
name: Von Keyserlingk, Marina A. G.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Zebrafish, a highly-social species of freshwater fish, are widely studied across many fields of laboratory science including developmental biology, neuroscience, and genomics. Nevertheless, as standard housing for zebrafish typically consists of small and simplistic environments, less is known about their social behavioral repertoire in more naturalistic settings. In particular, spontaneously occurring, socio-positive affiliative behaviors (e.g., social coordination and cohesion) that may be indicative of positive emotional experiences have rarely been reported or studied deliberately in zebrafish. Housing adult zebrafish (10 fish/tank) in large semi-natural tanks (110 L; n = 6) with sloping gravel substrate, rocks, and artificial plants, we observed a previously undescribed behavior: Distinct periods of spontaneous, synchronized, compact aggregations, what we call “heightened-shoaling”. This project aimed to quantify the characteristics of this distinctive behavior and compare parameters of heightened-shoaling to baseline periods (normal behavior) and pre-feed periods (feed-anticipatory behavior). First, across 4 days, we selected video-clips (100 s each) from within (i) instances of heightened-shoaling (n = 9), (ii) baseline periods (n = 18), and (iii) pre-feed periods (n = 18). For each of these video clips, we scan sampled every 10 s to determine fish orientations and location within the tank and agonistic behavior. Next, we used an all-occurrence sampling method to record the timing and duration of all episodes of heightened-shoaling behavior when tank-lights were on (8:00 h to 18:00 h) across 10 days. From the scan-sampling data, we found that compared to baseline periods, heightened-shoaling was characterized by increased shoal cohesion (p < 0.0001), increased adherence to the horizontal plane (p < 0.0001), decreased agonism (p < 0.0001), and no diving behavior (lower positions within the water column signal negative effect in zebrafish, p > 0.1). From the all-occurrence sampling data, we found 31 episodes of heightened-shoaling with instances observed in all six tanks and only a single case in which heightened-shoaling occurred in two tanks at the same time. The median episode duration was 7.6 min (Range 1.3–28.6). As the first systematic description of heightened-shoaling behavior, this research contributes to our knowledge of the range of zebrafish social dynamics living in naturalistic environments. Moreover, as a spontaneously occurring, protracted, affiliative behavior, heightened-shoaling appears to be a good candidate for future research into positive emotional behavior in zebrafish.
Uni Ulm intern - das Ulmer Universitätsmagazin, Nr. 304 (40. Jg.), Juni 2010
Creators: name: (:Unkn) Unknown
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: Uni Ulm intern
subject: DDC 050 / General serial publications
subject: Universities; Germany; Ulm
subject: Ulm / Universität

description: N/A
Applying genetic programming to scripted mobile robotics
Creators: name: August, Riley
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Engineering, Robotics.
subject: Computer Science.

description: In this thesis, we develop a new language for genetic programming, specifically designed for high-level controller scripting on mobile robots. We then test this language against previous conventions on the Robots Everywhere Antbot platform. We develop a genetic programming framework using Python and the new language, to create corridor-following programs in a simple simulation. Using this framework, we conduct a variety of experiments to find good parameters and techniques that apply to this new language, which can evolve the best controllers. Our results suggest that hierarchical GP using a measure of elitism is likely the best solution, and that the new language is very capable of evolving solutions with a high degree of robustness and generality.
title: L’importanza pratica del punto di vista estetico. La bellezza salverà il diritto (e le città)?
Creators: name: Stanzione, Giovanna
Publisher: name: Italian Society for Law and Literature (ISLL)
Year: 2024

description: [Will Beauty Save the Law (and the Cities)?] George Steiner wrote that language and art exist due to the presence of the Other, a concept shared with the law, which also derives its existence from the Other. Cities, too, are intricately connected to this concept, serving as aggregations of Others and primarily providing habitation for people. The verb "to inhabit," as noted by Heidegger, embodies humanity's relationship with the Earth, reflecting the essence of human nature. Similarly, lawyers, artists, and urban architects recognize the profound influence of ever-changing human nature on their work. Within this framework, an exploration of Beauty, as a fundamental aspect of human life, becomes unavoidable in legal and political fields.
The role of the retinoblastoma protein in cortical neurogenesis
Creators: name: Ferguson, Kerry L
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Biology, Neuroscience.

description: The retinoblastoma (Rb) protein was known to be a critical cell cycle regulator in tumour cells, however, little was known regarding its role in normal neural development. To determine the importance of the Rb signalling pathway in neural precursor proliferation and differentiation, I first characterized the key cell cycle regulators and examined the requirement for Rb in these processes. In contrast to previous studies, dominant negative CDK4/6 mutants induced mitotic arrest in neural precursors, despite the binding and sequestration of the Cip/Kip CKIs, p21Cip1 and p27 Kip1. The activity of these mutants was Rb-dependent, indicating that activation of the Rb pathway was sufficient to cause cell cycle arrest in neural precursor cells. While the phenotype of Rb germline knockouts indicated a requirement for Rb in neural precursor differentiation and survival, embryonic lethality and contradictions in the literature precluded a definitive answer. To assess the neural requirement for Rb in the absence of pleiotropic defects, I examined a conditional knockout in which Rb was specifically deleted in the developing telencephalon. These mutants survived to birth and exhibited minimal apoptosis. Although Rb-/- progenitor cells divided ectopically, they were able to survive and differentiate. Due to increased neuroblast proliferation, mutant telencephalic lobes were significantly enlarged. These studies demonstrated that cell cycle deregulation during differentiation does not necessitate apoptosis and terminal mitosis may not be required to initiate differentiation. I next examined the impact of Rb deficiency on cortical development and neuronal differentiation. By histological examination and in situ analyses, Rb mutants were found to exhibit defective laminar organization and region-specific cellularity. Although the majority of cortical neurons survived in the absence of Rb, specific populations, such as Cajal-Retzius neurons, required Rb for survival. By the selective reduction of calbindin- and Lhx6-positive interneurons from the cortical MZ, Rb was shown to regulate these tangentially migrating populations. These studies revealed a role for Rb in the development of cortical architecture, neuronal migration and its requirement in diverse neuronal populations. Together, my studies demonstrated critical functions for Rb in the developing cortex, from the regulation of precursor differentiation to cell type-specific requirements in neuronal survival and migration.
Psychosocial stress and longitudinally measured gestational weight gain throughout pregnancy: the Ulm SPATZ health study
Creators: name: Braig, Stefanie
name: Logan, Chad A.
name: Reister, Frank
name: Rothenbacher, Dietrich
name: Genuneit, Jon
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Hair cortisol
subject: Eating behavior
subject: 3rd trimester
subject: DDC 150 / Psychology
subject: DDC 610 / Medicine & health
subject: Pregnant women; Psychology
subject: Mental health
subject: Eating
subject: Obesity
subject: Depression
subject: Anxiety
subject: Weight gain
subject: Psychosoziale Belastung
subject: Schwangere
subject: Essgewohnheit
subject: Gewichtszunahme

description: Psychosocial stress is thought to influence gestational weight gain (GWG), but results are inconsistent. We investigated the relationship of questionnaire-based maternal stress and related constructs assessed at childbirth with maternal weight measured throughout pregnancy. Data were derived from the Ulm SPATZ Health Study, a birth cohort recruited from the general population (04/2012–05/2013, Ulm, Germany). Adjusted generalized estimating equations were performed. Regression coefficients (b) and 95% confidence intervals, each highest versus lowest tertile of stress or related constructs, are presented. In 748 women, we observed positive associations for maternal chronic stress (b = 4.36 kg (1.77; 6.95)), depressive symptoms (b = 2.50 kg (0.14; 4.86)), anxiety symptoms (b = 3.26 kg (0.62, 5.89)), and hair cortisol (b = 3.35 kg (0.86; 5.83)) with maternal weight at the first gestational month. GWG was considerably lower in mothers with higher chronic stress. Pregnancy-related anxiety was positively related to weight at first month (b = 4.16 kg (1.74; 6.58)) and overall GWG. In contrast, no association was observed between anxiety symptoms and GWG. Odds ratios for association with inadequate weight gain according to Institute of Medicine recommended cutoffs differed from the results presented obove. There is evidence of an association between stress and weight gain lying beyond the recommended cut-offs, which however needs further corroboration.
Model reaction for a synthesis of streptamine.
Creators: name: Wang, Margaret Ching-Tuan.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1968
Subjects: subject: Chemistry, Biochemistry.

description: Part I. trans,trans-1,3-Diacetamido-2-nitrocyclohexane (IV) was prepared from trans,trans-1,3-diacetoxy-2-nitrocyclohexane (II) by reaction with ammonia followed by acetylation. The configuration of IV was determined by studies of the n.m.r. spectra of two derivatives, trans,trans -2-amino-1,3-diacetamidocyclohexane (V) and trans,trans-1,2,3-triacetamidocyclohexane (VI). Permanganate oxidation of compound IV gave 2,6-diacetamidocyclohexanone (VII), whose 2,4-dinitrophenylhydrazone (VIII) was also prepared. The ketone VII was reduced by sodium borohydride and yielded trans,trans-2,6-diacetamidocyclohexanol (IX), whose configuration was confirmed by its n.m.r. spectrum and by that of its derivative, trans,trans-2,6-diacetamidocyclohexanol acetate (XI). The Clemmensen reduction of compound VII was investigated as a possible route to 1,3-diacetamidocyclohexane (XII). Action of ammonia followed by N-acetylation converted deoxynitro-scyllo-inositol pentaacetate (XIII) into 1,3-diacetamido-2-deoxy-2-nitro-scyllo-inositol (XIV). Part II. 3-Phthalidylnitromethane (XIII) was allowed to react with triethylamine in anhydrous methylene chloride to give 2-(2-nitrovinyl) benzoate ion (XIV) as suggested by the ultraviolet spectrum. Upon subsequent addition of diazomethane two products were isolated, neither of which had retained the nitro group and only one of which contained methoxyl. Possible molecular formulas for these products are discussed.
Study of Psychological Distress and Quality of Life in a Rural District of Bangladesh
Creators: name: Uddin, Mohammed Nazim
Publisher: name: Swinburne
Year: 2024

description: A significant proportion of global disease attributed to mental and behavioural disorders. People with mental health conditions (MHCs) have lower levels of health-related quality of life. However, there is a lack of evidence in the literature regarding MHCs and screening tools for measuring psychological distress or quality of life. The study recruited 2,425 participants to check current awareness of MHCs and validate the Kessler Psychological Distress Scale (K10) and the World Health Organization Quality of Life (WHOQOL) scale in Rural Bangladesh. Participant awareness of MHCs appeared to be very low. The research suggested modifying those scales and proposed the seven-item of K10 and 19-item WHOQOL instead, which would be extremely useful for such screenings in the Bangladeshi context.
Supplementary document for filter construction using Ronchi masks and Legendre polynomials to analyze the noise in aberrations applying the irradiance transport equation - 4661363.pdf
Creators: name: Hernández, Jesús Arriaga
name: Otahola, Bolivia
name: Oliveros, Jose
name: Jaramillo-Núñez, Alberto
name: Castillo, María Morín
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Uncategorized
Image Processing
Optical Physics not elsewhere classified

description: Supplemental material
Hypoxia-induced gene expression results from selective mRNA partitioning to the endoplasmic reticulum
Creators: name: Staudacher, Jonas J.
name: Naarmann-De Vries, Isabel S.
name: Ujvari, Stefanie J.
name: Klinger, Bertram
name: Kasim, Mumtaz
name: Benko, Edgar
name: Ostareck-Lederer, Antje
name: Ostareck, Dirk H.
name: Persson, Anja Bondke
name: Lorenzen, Stephan
name: Meier, Jochen C.
name: Blüthgen, Nils
name: Persson, Pontus B.
name: Henrion-Caude, Alexandra
name: Mrowka, Ralf
name: Fähling, Michael
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie

description: Protein synthesis is a primary energy-consuming process in the cell. Therefore, under hypoxic conditions, rapid inhibition of global mRNA translation represents a major protective strategy to maintain energy metabolism. How some mRNAs, especially those that encode crucial survival factors, continue to be efficiently translated in hypoxia is not completely understood. By comparing specific transcript levels in ribonucleoprotein complexes, cytoplasmic polysomes and endoplasmic reticulum (ER)-bound ribosomes, we show that the synthesis of proteins encoded by hypoxia marker genes is favoured at the ER in hypoxia. Gene expression profiling revealed that transcripts particularly increased by the HIF-1 transcription factor network show hypoxia-induced enrichment at the ER. We found that mRNAs favourably translated at the ER have higher conservation scores for both the 5′- and 3′-untranslated regions (UTRs) and contain less upstream initiation codons (uAUGs), indicating the significance of these sequence elements for sustained mRNA translation under hypoxic conditions. Furthermore, we found enrichment of specific cis-elements in mRNA 5′- as well as 3′-UTRs that mediate transcript localization to the ER in hypoxia. We conclude that transcriptome partitioning between the cytoplasm and the ER permits selective mRNA translation under conditions of energy shortage.
Comparative analysis of different platelet lysates and platelet rich preparations to stimulate tendon cell biology : an in vitro study
Creators: name: Klatte-Schulz, Franka
name: Schmidt, Tanja
name: Uckert, Melanie
name: Scheffler, Sven
name: Kalus, Ulrich
name: Rojewski, Markus
name: Schrezenmeier, Hubert
name: Pruss, Axel
name: Wildemann, Britt
Publisher: name: Universität Ulm
Year: 2018
Subjects: subject: platelet rich plasma
subject: platelet lysate
subject: tenocyte-like cells
subject: tendon healing
subject: DDC 570 / Life sciences
subject: DDC 610 / Medicine & health
subject: Tendons
subject: Tendon injuries
subject: Platelet-rich plasma
subject: Cell culture techniques
subject: Sehnenverletzung
subject: Thrombozytenreiches Plasma
subject: Zellkultur

description: The poor healing potential of tendons is still a clinical problem, and the use of Platelet Rich Plasma (PRP) was hypothesized to stimulate healing. As the efficacy of PRPs remains unproven, platelet lysate (PL) could be an alternative with its main advantages of storage and characterization before use. Five different blood products were prepared from 16 male donors: human serum, two PRPs (Arthrex, (PRP-ACP); RegenLab (PRP-BCT)), platelet concentrate (apheresis, PC), and PL (freezing-thawing destruction of PC). Additionally, ten commercial allogenic PLs (AlloPL) from pooled donors were tested. The highest concentration of most growth factors was found in AlloPL, whereas the release of growth factors lasted longer in the other products. PRP-ACP, PRP-BCT, and PC significantly increased cell viability of human tenocyte-like cells, whereas PC and AlloPL increased Col1A1 expression and PRP-BCT increased Col3A1 expression. MMP-1, IL-1β, and HGF expression was significantly increased and Scleraxis expression decreased by most blood products. COX1 expression significantly decreased by PC and AlloPL. No clear positive effects on tendon cell biology could be shown, which might partially explain the weak outcome results in clinical practice. Pooled PL seemed to have the most beneficial effects and might be the future in using blood products for tendon tissue regeneration.
Altered increase in STAT1 expression and phosphorylation in severe COVID‐19
Creators: name: Rincon‐Arevalo, Hector
name: Aue, Arman
name: Ritter, Jacob
name: Szelinski, Franziska
name: Khadzhynov, Dmytro
name: Zickler, Daniel
name: Stefanski, Luisa
name: Lino, Andreia C.
name: Körper, Sixten
name: Eckardt, Kai‐Uwe
name: Schrezenmeier, Hubert
name: Dörner, Thomas
name: Schrezenmeier, Eva V.
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: STAT1
subject: IRF9
subject: Type I interferon
subject: pSTAT1
subject: DDC 610 / Medicine & health
subject: COVID-19; Drug therapy
subject: Interferons
subject: Signal transduction
subject: COVID-19
subject: Pharmakotherapie
subject: Interferon

description: Abstract The interferon pathway, a key antiviral defense mechanism, is being considered as a therapeutic target in COVID‐19. Both, substitution of interferon and JAK/STAT inhibition to limit cytokine storms have been proposed. However, little is known about possible abnormalities in STAT signaling in immune cells during SARS‐CoV‐2 infection. We investigated downstream targets of interferon signaling, including STAT1, STAT2, pSTAT1 and 2, and IRF1, 7 and 9 by flow cytometry in 30 patients with COVID‐19, 17 with mild, and 13 with severe infection. We report upregulation of STAT1 and IRF9 in mild and severe COVID‐19 cases, which correlated with the IFN‐signature assessed by Siglec‐1 (CD169) expression on peripheral monocytes. Interestingly, Siglec‐1 and STAT1 in CD14+ monocytes and plasmablasts showed lower expression among severe cases compared to mild cases. Contrary to the baseline STAT1 expression, the phosphorylation of STAT1 was enhanced in severe COVID‐19 cases, indicating a dysbalanced JAK/STAT signaling that fails to induce transcription of interferon stimulated response elements (ISRE). This abnormality persisted after IFN‐α and IFN‐γ stimulation of PBMCs from patients with severe COVID‐19. Data suggest impaired STAT1 transcriptional upregulation among severely infected patients may represent a potential predictive biomarker and would allow stratification of patients for certain interferon‐pathway targeted treatments.
description: Anomalous upregulation of STAT1 and IRF9 (key components of IFN signaling) in B and T cells and monocytes from patients with severe COVID‐19, with absence of pSTAT1 upregulation upon IFN restimulation. Mild COVID‐19 group had strong STAT1 and IRF9 upregulation. image
Prisoner subjectivity: Exploring forms of self-government and everyday acts of resistance
Creators: name: Chartrand, Vicki
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Sociology, Criminology and Penology.

description: Through a qualitative approach of seven life-sentenced prisoner interviews, I explore prisoner practices, relations, and perceptions to gain a certain insight into how the prisoners manage themselves and their sentence. The research findings reveal that, through self-forming activities and practices, prisoners self-govern their conduct in an attempt to maintain an autonomous sense of self while attempting to improve their chances for release. I conclude that a Foucauldian analysis of subjectivity is a useful tool to investigate the prison as it reveals how prisoners continually negotiate their concept of 'self' between the goals of the prison and with their own ways of 'doing' and 'being'. Despite its controlling nature, prisoners subtly resist individualizing forms of power that seek to submit them towards conformity. Such an approach opens a space for prisoner agency to emerge and directs our attention towards those forming activities of the prison that fail to correspond with the lived realities of the prisoner and their concept of 'self'. (Abstract shortened by UMI.)
Potenzielle SVHC in Umwelt und Erzeugnissen
Creators: name: Wirth, Olaf
name: Bliklen, Rebecca
name: Rödig, Lisa
Publisher: name: Deutschland. Umweltbundesamt
Year: 2019
Subjects: Perfluorierter Kohlenwasserstoff
Chemikalien
Schadstoffexposition
Besonders besorgniserregende Stoffe
Datengewinnung

description: Der Bericht umfasst die Kernergebnisse zweier Informationssammlungen, die es ermöglichen sollten Risiken zu beurteilen die von per- und polyflourirten Chemicalien (PFC) ausgehen können, mit dem Ziel die Anhang XV Dossiers erstellen zu können, um möglicherweise Beschränkungen im Rahmen von REACH anzustoßen. Die Arbeiten umfassten konkret Informationserhebungen zu den langkettigen perflourierten alkylierten Carboxylsäuren (engl. long-chain per- and polyfluorinated carboxylic acids - long-chain PFCA) sowie den kurzkettigen per- und polyflourinierten alkylierten Stoffen (short-chain per- and polyfluorinated alkylated substances - short-chain PFAS). Eingeschlossen in die Datenerhebung waren zudem die Salze der beiden Stoffgruppen, Vorläuferstoffe sowie Stoffe, wie Polymere, die diese Stoffe als strukturelle Elemente enthalten. Die Informationen wurden über Literaturstudien, IT-gestützte Umfragen sowie gezielte Interviews mit Interessensvertretern erhoben. Des Weiteren enthält der Bericht auch grundsätzliche Überlegungen zum Nutzen IT-gestützter Umfragen im Rahmen solcher Informationserhebungen im Rahmen regulatorische Aktivitäten unter REACH. Quelle: Forschungsbericht
description: The report covers main findings of two information collection activities that have been performed with the aim to collect basic information to be able to assess risks that originate from per- and polyfluorinated compounds (PFC) in the frame of the preparation of Annex XV Dossiers to initiate a restriction under REACH. The work covered in particular long-chain per- and polyfluorinated carboxylic acids (long-chain PFCA) and short-chain per- and polyfluorinated alkylated substances (short-chain PFAS). Also included were the salts of the two groups, precursor substances and substances, such as polymers, that contain these substances as structural element. Information were collected via literature research, IT-based surveys and targeted interviews with stakeholders. Furthermore, the report contains some general considerations on the use of IT-based surveys in the context of such information collections in regulatory activities under REACH. Quelle: Forschungsbericht
CODEX: Measuring the acceleration of the universe and beyond
Creators: name: Pasquini, Luca
name: Cristiani, S.
name: Dekker, H.
name: Haehnelt, M.
name: Molaro, P.
name: Pepe, F.
name: Avila, G.
name: Delabre, B.
name: D'Odorico, S.
name: Liske, J.
name: Shaver, P.
name: Bonifacio, P.
name: Borgani, S.
name: D'Odorico, V.
name: Vanzella, E.
name: Bouchy, F.
name: Dessauges, M.
name: Lovis, C.
name: Mayor, M.
name: Queloz, D.
name: Udry, S.
name: Murphy, Michael
name: Viel, M.
name: Grazian, A.
name: Levshakov, S.
name: Moscardini, L.
name: Wiklind, T.
name: Zucker, S.
Publisher: name: Swinburne
Year: 2024

description: The combination of the collecting power of an ELT with an ultra-stable high resolution spectrograph opens up the possibility to measure for the first time directly the dynamical effect of the acceleration of the Universe. CODEX will also provide unique opportunities for advance in many other branches of astrophysics. The CODEX design is based on an array of several identical spectrographs. It is highly modular and can be easily adapted to a large range of sky apertures and telescope diameters. CODEX is designed to work as a seeing limited instrument. The requirements for the telescope are moderate and clearly identified.
Archbishop Elias Zoghby and his efforts at Orthodox-Catholic reconciliation within the Patriarchate of Antioch: An exposition in the light of contemporary ecumenical thought
Creators: name: Aboueid, Suzane Mary
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Theology.

description: This thesis studies Archbishop Elias Zoghby and his efforts at Orthodox-Catholic reconciliation within the Patriarchate of Antioch in the light of contemporary ecumenical thought. He has spent the past forty years promoting the cause of unity among the Catholic and Orthodox Churches and has written several articles and books on the unification of the Byzantine Churches of Antioch. Kyr Elias encountered many challenges and criticisms for his project of Double Communion and received much attention for his theological contributions. Although his ideas have been set aside as impractical, it is argued that his treatment of the subject of ecumenism is based on the experiences of everyday life of the lay faithful of Antioch. As such it is a viable representation of lived communion. Chapter One examines briefly the history of the Church of Antioch its experience of the tragedy of schism, and its special vocation to breaking new ground, all from a perspective that helps to better understand the present ecumenical climate within that Church and the milieu from which Archbishop Zoghby emerged. Chapter Two introduces the man himself, his life and his ministry. In the third chapter the written ecumenical works of Archbishop Zoghby are examined chronologically. In Chapter Four is an analysis of his ideas, explored by means of the reactions of both the Catholic and the Orthodox authorities to his initiatives. Furthermore, this chapter sets Kyr Elias's writings alongside the ecumenical ideas of Pope John Paul II's encyclical Ut Unum Sint in order to compare and contrast the two. The conclusion notes some of the weaknesses of Archbishop Zoghby's initiative, but also highlights some aspects of his proposals that have not yet been fully accepted and perhaps not even fully understood by the ecumenical movement at large.
Developing a Robust Ceramic Pressure-Driven Membrane-Based System for the Efficient Removal of Pollutants from Mining Wastewaters
Creators: name: Samaei, Seyed Mohsen
Publisher: name: Swinburne
Year: 2024

description: Due to increased water shortages and environmental protection concerns, treated industrial effluents including treated mining wastewater has been accepted as a sustainable option to address these problems. The research objective was to develop and investigate the efficiency of a ceramic membrane-based system in mining operations, thereby producing treated wastewater fit for recycling or reusing with reduced environmental impacts and health risks. The designed system has high durability, superior chemical, mechanical and thermal stability, and bacteria resistance. It will benefit the mining sector as it has the potential to guarantee steady-state long-term operations without any or minimum requirement for parts replacement.
The constituent aspects of synchresis: A practice-led examination of audio-visual synchronization in key sites of production
Creators: name: Presser, Hugo
Publisher: name: Swinburne
Year: 2024

description: With the aim of deconstructing audio-visual synchronism and forging new approaches to synchresis, the methods used in this project contribute a unique research undertaking in the form of a practice-led method that is supported by an examination of synchresis in music video and commercial advertising production. This submission is comprised of two parts: a written component herein, alongside an artefact component of original music and music video that has been created in dialogue with the written submission.
Comparison of different risk classification systems in 558 patients with gastrointestinal stromal tumors after R0-resection
Creators: name: Schmieder, Michael
name: Henne-Bruns, Doris
name: Mayer, Benjamin
name: Knippschild, Uwe
name: Deufel, Claudia
name: Schwab, Matthias
name: Kramer, Klaus Michael
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: GIST
subject: TKI
subject: risk classification
subject: DDC 610 / Medicine & health
subject: Gastrointestinal stromal tumors
subject: Prognosis
subject: Treatment outcome
subject: Gastrointestinaltrakt
subject: Sarkom
subject: Prognose
subject: Therapieerfolg

description: Background: Due to adjuvant treatment concepts for patients with R0-resected gastrointestinal stromal tumors (GIST), a reproducible and reliable risk classification system proved of utmost importance for optimal treatment of patients and prediction of prognosis. The aim of this study was to reevaluate the impact of five widely-applied and well-established GIST risk classification systems (i.e., scores by Fletcher, Miettinen, Huang, Joensuu, and TNM classification) on a series of 558 GIST patients with long-term follow-up after R0 resection. Methods: Tumor size, mitotic count and site were used in variable combination to predict high- and low risk patients by the use of the five risk classification models. For survival analyses disease-specific survival, disease-free survival and overall-survival were investigated. Patients with initial metastatic disease or incompletely resectable tumors were excluded. Results: All GIST classification models distinguished well between patients with high-risk and low-risk tumors and none of the five risk systems was superior to predict patient outcome. The models showed significant heterogeneity. There was no significant difference between the different risk-groups regarding overall-survival. Subdivision of GIST patients with very low- and low-risk appeared to be negligible. Conclusions: Currently applied GIST risk classification systems are comparable to predict high- or low-risk patients with initial non-metastatic and completely resected GIST. However, the heterogeneity of the high-risk group and the absence of differences in overall survival indicate the need for more precise tumor- and patient-related criteria for better stratification of GIST and identification of patients who would benefit best from adjuvant tyrosine kinase inhibitor therapy.