cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Bartlett corrections in beta regression models
Creators: name: Bayer, Fábio M.
name: Cribari-Neto, Francisco
Publisher: name: arXiv
Year: 2015
Subjects: subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences
subject: 62F03, 62F05, 62F40, 62E17, 62E20

description: We consider the issue of performing accurate small-sample testing inference in beta regression models, which are useful for modeling continuous variates that assume values in $(0,1)$, such as rates and proportions. We derive the Bartlett correction to the likelihood ratio test statistic and also consider a bootstrap Bartlett correction. Using Monte Carlo simulations we compare the finite sample performances of the two corrected tests to that of the standard likelihood ratio test and also to its variant that employs Skovgaard's adjustment; the latter is already available in the literature. The numerical evidence favors the corrected tests we propose. We also present an empirical application.
description: 27 pages, 5 tables, 3 figures
Frobenius Manifolds and Formality of Lie Algebras of Polyvector Fields
Creators: name: Barannikov, Sergey
name: Kontsevich, Maxim
Publisher: name: arXiv
Year: 1997
Subjects: subject: Algebraic Geometry (math.AG)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We construct a generalization of the variations of Hodge structures on Calabi-Yau manifolds. It gives a Mirror partner for the theory of genus=0 Gromov-Witten invariants
description: 12 pages, AMS-TeX; typos and a sign corrected, appendix added. Submitted to IMRN
Thermoresponsive oligo(ethylene glycol) methyl ether methacrylate homopolymers via RAFT polymerization in 1-alkyl-3-methylimidazolium hexafluorophosphate ionic liquids
Creators: name: Perez, Ser John Lynon P.
name: Montalbo, Reynaldo Carlos K.
name: Concio, Christian Angelo P.
name: Madrid, Ludhovik Luiz B.
name: Arco, Susan D.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology

description: Responsive polymer-based materials vary their physicochemical properties upon external stimuli. In the past decades, these materials have been utilized in diverse applications such as drug delivery, tissue engineering, biosensors, and surface coatings. In these applications, stimuli-responsive polymers with narrow dispersity are ideal to ensure good sensitivity. RAFT polymerization remains one of the living polymerization techniques that affords great control over polymer size and dispersity. Herein, we investigated how the solvent size, RAFT agent choice, and monomer size affect the RAFT polymerization of thermoresponsive OEGMEMA in hexafluorophosphate-based RTILs. Gel permeation chromatography (GPC) results showed that increased RTIL chain length resulted in an increased polymerization rate, polymer size and dispersity. The RAFT agent CPDB provided better control over the polymerization kinetics. Moreover, GPC data revealed an inverse relationship between the monomer size and the dispersity of its polymer. Monomer size also restricted polymer growth with decreasing rate through time. Among the homopolymers, P(DEGMEMA) synthesized in [HMIM]PF6 and CPBD exhibited the highest percent conversion, fastest reaction rate, and relatively high size uniformity. Our findings demonstrate that a thermoresponsive P(DEGMEMA) can be rapidly obtained in high molecular weights and conversion in RTILs.
Soft-gluon expansions through NNNLO
Creators: name: Kidonakis, Nikolaos
Publisher: name: arXiv
Year: 2005
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: I present universal master formulas for soft-gluon corrections to hard-scattering cross sections through next-to-next-to-next-to-leading order (NNNLO). I also briefly discuss applications to some processes where these corrections enhance the cross section and decrease the scale dependence.
description: 4 pages; presented at DIS 2005, Madison, Wisconsin, April 27-May 1, 2005
MPEC 2023-U132 : 2023 UQ2
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 UQ2

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Pendant propargyloxy-functionalized aromatic (co)polycarbonates: synthesis, thermal crosslinking and chemical modification
Creators: name: Nagane, Samadhan S.
name: Maher, Deepak M.
name: Verma, Savita
name: Talanikar, Aniket A.
name: Wadgaonkar, Prakash P.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Inorganic Chemistry
subject: 60506 Virology
subject: FOS: Biological sciences

description: A bisphenol monomer bearing pendant propargyloxy group viz, 1, 1-bis (4-hydoxyphenyl)-1-(4′-propargyloxyphenyl) ethane (BPP) was synthesized starting from commercially available 1, 1, 1-tris (4-hydroxyphenyl) ethane (THPE) by mono O-propargylation reaction using propargyl bromide. A new series of pendant propargyloxy-functionalized aromatic (co)polycarbonates was synthesized by low-temperature solution polycondensation of BPP or different molar ratios of BPP and bisphenol-A with triphosgene in dichloromethane in the presence of triethylamine. The formation of reasonably high molecular weight (co)polycarbonates was confirmed by inherent viscosity (0.52–0.83 dL/g) and gel permeation chromatography (Mn 37,000–69,800 g/mol, polystyrene standards) measurements. 13C NMR spectral studies supported formation of random copolycarbonates in copolymerization of BPP and BPA with triphosgene. The 10% weight loss temperature (T10) values of (co)polycarbonates, determined by thermogravimetric analysis under nitrogen atmosphere, were in the range 427–438 °C indicating their good thermal stability. The glass transition temperature (Tg) values of (co)polycarbonates were observed in the range 147–152 °C. The crosslinking ability of (co)polycarbonates involving pendant propargyloxy groups leading to formation of networked structure was evaluated via non-isothermal curing studies by DSC. As a proof-of-concept, the post-modification of a representative polycarbonate bearing pendant propargyloxy groups with 1-octane thiol as a model compound via thiol-yne click reaction was briefly studied.
Tissue-specific regulation of ACE/ACE2 and AT 1 /AT 2 receptor gene expression by oestrogen in apolipoprotein E/oestrogen receptor-α knock-out mice: Oestrogen regulation of ACE/ACE2 and AT1/AT2
Creators: name: Gallagher, Patricia
name: Smithies, Oliver
name: Maeda, Nobuyo
name: Brosnihan, K. Bridget
name: Hodgin, Jeffrey B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: ACE and ACE2 and the AT1 and AT2 receptors are pivotal points of regulation in the renin-angiotensin system. ACE and ACE2 are key enzymes in the formation and degradation of Ang II and Ang-(1-7). Ang II acts at either the AT1 or the AT2 receptor to mediate opposing actions of vasoconstriction/vasodilation. While it is known that estrogen (E2) acts to down-regulate ACE and the AT1 receptors, its regulation of ACE2 and the AT2 receptor and the involvement of a specific estrogen receptor subtype are unknown. To investigate the role of estrogen receptor-α (ERα) in estrogen’s regulation of ACE/ACE2 and AT1/AT2 mRNAs in lung and kidney, ovariectomized female mice lacking apolipoprotein E (ee) with the ERα (AAee) or without the ERα (ααee) were treated with 17-β estradiol (6 µg/day) or placebo for 3 months. ACE,ACE2 and AT1/AT2 receptor mRNAs were measured using reverse transcriptase, real-time polymerase chain reaction (RT/RT-PCR). In the kidney, 17-β estradiol showed 1.7 fold down-regulation of ACE mRNA in AAee mice, with 2.1-fold up-regulation of ACE mRNA in ααee mice. 17-β estradiol showed 1.5 and 1.8 fold down-regulation of ACE2 and AT1 receptor mRNA in AAee mice; this regulation was lost in ααee mice. 17-β estradiol showed marked (81-fold) up-regulation of the AT2 receptor mRNA in AAee mice. In the lung 17-β estradiol treatment had no effect on AT1 receptor mRNA in AAee mice, but resulted in a 1.5-fold decreased regulation of AT1 mRNA in ααee. There was no significant interaction of estrogen with ER in the lung for ACE, ACE2, and AT2 receptor genes. These studies reveal tissue specific regulation by 17-β estradiol of ACE/ACE2 and AT1/AT2 receptor genes with the ERα receptor primarily responsible for the regulation of kidney ACE2 , AT1 receptor, and AT2 receptor genes.
A Simple Model for Long-Range Interacting Pendula
Creators: name: Myers, Owen
name: Del Maestro, Adrian
name: Wu, Junru
name: Marshall, Jeffrey S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Classical Physics (physics.class-ph)
subject: FOS: Physical sciences

description: We show that the Hamiltonian mean field (HMF) model describes the equilibrium behavior of a system of long pendula with flat bobs that are coupled through long-range interactions (charged or self gravitating). We solve for the canonical partition function in the coordinate frame of the pendula angles. The Hamiltonian in the angles coordinate frame looks similar to the form of the HMF model but with the inclusion of an index dependent phase in the interaction term. We also show interesting non-equilibrium behavior of the pendula angles, namely that a quasistationary clustered state can exist when pendula angles are initially ordered by their index.
Shifting Focus: Asian German Film Representation since 1910
Creators: name: Fitzpatrick, Zach Ramon
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: Uncategorized

description: SHIFTING FOCUS: ASIAN GERMAN FILM REPRESENTATION SINCE 1910 constitutes the first ever full-length critical history of Asia and Asians within German cinema. I insist that Asian subjects and influence in German film are not wholly invisible, as is often polemically stated. Instead, Asians on German screens are figuratively blurry and out of focus, in a depth of field beyond our line of sight. Refocusing our attention on Asian representation reveals over 300 films that belong to a counter-history of German cinema since 1910. The main criterion of my selection process for films to analyze is the prevalence of South, Southeast, and/or East Asian topoi. By including films with Asian settings, Asian filming locations, Asian characters, credited actors of Asian descent in at least supporting roles, Asian-coded props, and/or film titles referencing Asia, I have amassed a substantial body of films fulfilling some or all of these criteria. Chapter Two of this dissertation provides a chronological overview, writing Asian representation (back) into German film history. Chapter Three explores recurring tropes in the representations of Asians through German cinema, tracing how certain filmic stereotypes employed a century ago still occur today. Chapter Four outlines a selection of subversive and empowering moments in film history that complicate the recurring representational stereotypes covered in Chapter Three. After these more overarching chronological and thematic/formal analyses, Chapters Five and Six spotlight two landmark examples of Asian German representation that are, thus far, lacking in critical scholarship; through theoretically informed analyses, these case studies will demonstrate the importance of an Asian German film studies lens. My dissertation looks beyond traditional notions of national cinema and the canon to paint a more heterogeneous, nuanced picture of who and what comprises German cinema and culture. The increased awareness of anti-Asian racism sparked by reactions to COVID-19 is a reminder that my work is prescient, as it provides a visual/filmic history of Orientalist discourses and tropes that have helped shape conceptions of Asianness today. However, I also use this broad corpus of films to highlight several opportunities for the contemporary Asian German community to find much-needed points of identification and empowerment.
Challenges and Opportunities in Running Kubernetes Workloads on HPC
Creators: name: Chazapis, Antony
name: Maliaroudakis, Evangelos
name: Nikolaidis, Fotis
name: Marazakis, Manolis
name: Bilas, Angelos
Publisher: name: Zenodo
Year: 2024

description: Cloud and HPC increasingly converge in hardware platform capabilities and specifications, nevertheless still largely differ in the software stack and how it manages available resources.The HPC world typically favors Slurm for job scheduling, whereas Cloud deployments rely on Kubernetes to orchestrate container instances across nodes. Running hybrid workloads is possible by using bridging mechanisms that submit jobs from one environment to the other.However, such solutions require costly data movements, while operating within the constraints set by each setup's network and access policies. In this presentation, we introduce an container-based approach design that enables running unmodified Kubernetes workloads directly on HPC systems, by having users deploy their own private Kubernetes mini Cloud, which internally converts container lifecycle management commands to use the HPC system-level Slurm infrastructure for scheduling and Singularity/Apptainer as the container runtime. We consider this approach to be practical for deployment in HPC centers, as it requires minimal pre-configuration and retains existing resource management and accounting policies.
title:  Arctic Leverage: Canadian Sovereignty and Security
Creators: name: Caldwell Jr., Nathaniel French
Publisher: name: Old Dominion University Libraries
Year: 1989

description: In 1987 the Canadian government recognized that in order to be a major player in collective security with the United States and NATO, it would have to make a significant contribution to the common defense. However. since Canada could not hope to outspend the larger powers, its contribution would have to be leveraged by control of a strategic piece of real estate -- the Canadian Arctic. The major program to enhance Canadian control of the Arctic would be the acquisition of ten-to-twelve nuclear attack submarines. That submarine force was sold to the public and Parliament as a means to enhance Canadian sovereignty which was perceived to be threatened by United States activities in the Arctic. Historically, Canadian sovereignty has been promoted, not threatened, when Arctic terr·itory has been perceived as strategically critical to North American defense. Canadian control of the Northwest Passage is meant to magnify Canada's voice in collective security well beyond its relative contribution.
Mesenchymal stem cells at the intersection of cell and gene therapy
Creators: name: Li, Tieshi
name: Spagnoli, Anna
name: Yan, Yun
name: Myers, Timothy J
name: Longobardi, Lara
name: Granero-Molto, Froilan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Mesenchymal stem cells have the ability to differentiate into osteoblasts, chondrocytes and adipocytes. Along with differentiation, MSCs can modulate inflammation, home to damaged tissues and secret bioactive molecules. These properties can be enhanced through genetic-modification that would combine the best of both cell and gene therapy fields to treat monogenic and multigenic diseases.
Vibration of low amplitude imaged in amplitude and phase by sideband versus carrier correlation digital holography
Creators: name: Verrier, N
name: Alloul, L
name: Gross, M
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Sideband holography can be used to get fields images (E0 and E1) of a vibrating object for both the carrier (E0) and the sideband (E1) frequency with respect to vibration. We propose here to record E0 and E1 sequentially, and to image the correlation E1E * 0 . We show that this correlation is insensitive the phase related to the object roughness and directly reflect the phase of the mechanical motion. The signal to noise can be improved by averaging the correlation over neighbor pixel. Experimental validation is made with vibrating cube of wood and with a clarinet reed. At 2 kHz, vibrations of amplitude down to 0.01 nm are detected.
Classification of Kaehler homogeneous manifolds of non-compact dimension two
Creators: name: Ahmadi, Seyed Ruhallah
name: Gilligan, Bruce
Publisher: name: arXiv
Year: 2015
Subjects: subject: Complex Variables (math.CV)
subject: FOS: Mathematics
subject: 32M10

description: Suppose $G$ is a connected complex Lie group and $H$ is a closed complex subgroup such that $X := G/H$ is Kaehler and the codimension of the top non-vanishing homology group of $X$ with coefficients in $\mathbb Z_2$ is less than or equal to two. We show that $X$ is biholomorphic to a complex homogeneous manifold constructed using well-known basic building blocks, i.e., $\mathbb C, \mathbb C^*$, Cousin groups, and flag manifolds.
Cardanol and bisphenol-F based benzoxazines with zirconium phosphate reinforced composites coating for protecting the mild steel surface from corrosion
Creators: name: Latha, Govindraj
name: Hariharan, Arumugam
name: Balaji, Krishnasamy
name: Kumaravel, Ammasai
name: Alagar, Muthukaruppan
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Cancer

description: The present work is to develop and characterize the benzoxazines from cardanol and bisphenol-F with imdazole core based amine in order to utilize them in the form of (50/50 wt%) blended composites coating for corrosion resistance application. The benzoxazine blends were reinforced with varying weight percentages of (0.5, 1, 1.5, 2.0 and 2.5 wt%) of 3-glycidoxypropyltrimethoxysilane (GPTMS) functionalized zirconium phosphate (ZrP) to obtain respective composites blended coatings. The thermal stability of composites was studied by thermogravimetric analysis (TGA). In order to ascertain their hydrophobic behavior the water contact angle studies were carried out and the values obtained for 0.5, 1, 1.5, 2.0 and 2.5 wt% GPTMS functionalized ZrP reinforced (50/50 wt% of C-ima/BF-ima) benzoxazines blended composites are 114,116,117,119,120 and 123° respectively. The UV shielding behavior of ZrP reinforced polybenzoxazine blended composites material was also studied by UV-Vis spectroscopic technique and the results obtained infer that these materials possess good UV shielding behavior. ZrP reinforced benzoxazine blended composites were coated on the mild steel specimens and their corrosion resisting behavior was studied. Results of Nyquist plot and Tafel plot, ascertain that among the coated specimens, the specimen coated with 2.5 wt% ZrP reinforced poly(C-ima/BF-ima) blended composites exhibits highest corrosion resisting efficiency.
Euclidean Time Formulation for the Superstring Ensembles: Perturbative Canonical Ensemble with Neveu-Schwarz B Field Backgrounds
Creators: name: Chaudhuri, Shyamoli
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The lengthy discussion and derivations given in this paper have been corrected, and completed with additional results and greater simplicity. We show that the high temperature limits of the heterotic E8xE8 and Spin(32)/Z2 strings and their Type I A/B superstring duals are finite and convergent. The Hagedorn growth of the degeneracies in the string mass level expansion is suppressed by an exponential linear in the mass level number for both heterotic strings, and suppressed by the exponential of the negative square root of the mass level number for the Type IB superstring. However, in the massless gauge field theoretic limit of the Type IB open and closed superstring, we find clear evidence for the thermal deconfinement phase transition at the self-dual temperature by examining the annulus graph alone. Above the self-dual temperature, there is a discontinuity in the first derivative with respect to temperature of both the free energy, and the heavy quark potential, leading to a deconfined thermal gluon ensemble, with universal 1/r potential, and temperature dependent corrections, as predicted by Luscher and Weisz. A number of essential aspects of the worldsheet formalism of the heterotic strings are derived in an appendix, deducing thereby the O8-D0-D8brane Type IA duals of all of the heterotic CHL island universe moduli spaces.
description: 52 pages
Controlled rephasing of single collective spin excitations in a cold atomic quantum memory
Creators: name: Albrecht, Boris
name: Farrera, Pau
name: Heinze, Georg
name: Cristiani, Matteo
name: de Riedmatten, Hugues
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We demonstrate active control of inhomogeneous dephasing and rephasing for single collective atomic spin excitations (spin-waves) created by spontaneous Raman scattering in a quantum memory based on cold $^{87}$Rb atoms. The control is provided by a reversible external magnetic field gradient inducing an inhomogeneous broadening of the atomic hyperfine levels. We demonstrate experimentally that active rephasing preserves the single photon nature of the retrieved photons. Finally, we show that the control of the inhomogeneous dephasing enables the creation of time-separated spin-waves in a single ensemble, followed by a selective readout in time. This is an important step towards the implementation of a functional temporally multiplexed quantum repeater node.
description: 5 pages, 4 figures
Strategies to circumvent humoral immunity to adeno-associated viral vectors
Creators: name: Tse, Longping V
name: Asokan, Aravind
name: Moller-Tank, Sven
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Recent success in gene therapy of certain monogenic diseases in the clinic has infused enthusiasm into the continued development of recombinant adeno-associated viral (AAV) vectors as next-generation biologics. However, progress in clinical trials has also highlighted the challenges posed by the host humoral immune response to AAV vectors. Specifically, while pre-existing neutralizing antibodies (NAbs) limit the cohort of eligible patients, NAb generation following treatment prevents vector re-dosing.
Exploring the Potential of Native Urease-Producing Bacteria of Hilly Terrain for Soil Strength Enhancement
Creators: name: Devrani, Rituraj
name: Vangla, Prashanth
name: Sharma, Shilpi
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Bio-cementation of weathered soils of hilly regions using native ureolytic bacteria is a practical approach to improve soil strength. This study aimed to isolate and characterize native urease-producing bacterial strains from different slope failure regions of Uttarakhand, India, through multi-step screening, and showcased their potential in soil improvement. A total of 80 bacterial strains were isolated from thirteen landslide-prone sites to screen for potent native urease-producing strains. Interestingly, nine native strains exhibited high calcium carbonate precipitation (158–187 mg/10 ml) and urease activity (657–3495 µM/mL) compared to Sporosarcina pasteurii (NCIM 2477), a potent bacterium commonly used for bio-cementation. These strains belonged to various genera, including Lysinibacillus sp., Sporosarcina sp., Pseudochrobactrum sp., and Cytobacillus sp. Cohesionless soil samples treated with the native strains exhibited high unconfined compressive strength values ranging from 0.1 MPa to 1 MPa, whereas those treated with S. pasteurii were 0.15 MPa. The urease-producing bacterial strains with CaCO3 precipitation activity influenced the soil strength and failure patterns. FESEM, XRD, and acid-washing tests revealed that native bacterial strains precipitated CaCO3 more than S. pasteurii strain. The study explores, for the first time, the potential of native ureolytic bacteria from different regions of Uttarakhand, India, for soil strength enhancement.
Spectral asymptotics for canonical systems
Creators: name: Eckhardt, Jonathan
name: Kostenko, Aleksey
name: Teschl, Gerald
Publisher: name: arXiv
Year: 2014
Subjects: subject: Spectral Theory (math.SP)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: Primary 34B20, 47B15, Secondary 47B32, 34B30

description: Based on continuity properties of the de Branges correspondence, we develop a new approach to study the high-energy behavior of Weyl-Titchmarsh and spectral functions of $2\times2$ first order canonical systems. Our results improve several classical results and solve open problems posed by previous authors. Furthermore, they are applied to radial Dirac and radial Schrödinger operators as well as to Krein strings and generalized indefinite strings.
description: 28 pages
Tumor-targeted delivery of siRNA by non-viral vector: safe and effective cancer therapy
Creators: name: Huang, Leaf
name: Chen, Yunching
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: RNA interference technology has been developed as a potential therapeutic agent for many indications, including cancer. Silencing a specific oncogene in tumor cells brings about cell death both in vitro and in vivo. However, there is a great need for powerful delivery strategies to enhance the therapeutic effect of small interfering RNA (siRNA). This review summarizes different signaling pathways inhibited by siRNA and the advantages of targeted siRNA as a delivery system.
Physicochemical and Biological Changes of Compost Inoculated with Pseudomonas Aeruginosa AAC1 and Rock Phosphate: Implications for P Availability
Creators: name: Ahmad, Areesha
name: Zafar, Urooj
name: Haq, Tooba
name: Qader, Shah Ali Ul
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology
subject: Computational Biology

description: Phosphorus (P) is an essential nutrient for plant growth, but its availability in soil is often limited. Present study was conducted to design compost enriched with phosphate-solubilizing bacteria (PSB) and rock phosphate (RP). Four compost piles were prepared with RP and 30:1 carbon-to-nitrogen (C: N). Out of these, two piles were inoculated with PSB strain Pseudomonas aeruginosa AAC1 (RP + AAC1) while two piles were left un-inoculated and served as control (RP). The physicochemical assessment of the designed compost revealed that the addition of RP and inoculation of P. aeruginosa AAC1 (RP + AAC1) significantly (p < 0.05) increased the composting temperature (over 58 °C), calcium (36.84%), magnesium (35%) and available P contents (43.50%) indicating the solubilization of inorganic P, Ca and Mg bound phosphates However, the addition did not significantly (p > 0.05) influence the carbon (C), carbon to nitrogen (C/N) ratio, organic matter, and ash content but significantly (p < 0.05) reduced the moisture content (41%) and pH (up to 5.4). After 60 days, all compost piles reached maturity at temperature ranges of 27-30 °C, pH level between 7.2–7.6, and moisture content 31-35%. Scanning electron microscopy and energy-dispersive X-ray spectrometry (SEM-EDS) confirmed the presence of elements including carbon (C), oxygen (O), magnesium (Mg), aluminum (Al), silicon (Si), calcium (Ca), and P (P) in the compost. Microbiological monitoring revealed the survival of P. aeruginosa AAC1 during the composting process even at higher temperatures (∼58 °C). Indigenous bacterial populations were recovered within the range of 109 - 1014 CFUg−1. Compost was also safe in regard to heavy metal concentrations. Thus, the results suggest that combining P. aeruginosa AAC1 and RP in compost can enhance the availability of soluble P, thus serving as an effective phosphatic biofertilizer.
A novel ACE2 decoy for both neutralization of SARS-CoV-2 variants and killing of infected cells
Creators: name: Kegler, Alexandra
name: Drewitz, Laura
name: Arndt, Claudia
name: Daglar, Cansu
name: Rodrigues Loureiro, Liliana
name: Mitwasi, Nicola M. J.
name: Neuber, Christin
name: González Soto, Karla Elizabeth
name: Bartsch, Tabea
name: Baraban, Larysa
name: Ziehr, Holger
name: Heine, Markus
name: Nieter, Annabel
name: Moreira-Soto, Andres
name: Kühne, Arne
name: Drexler, Jan Felix
name: Seliger, Barbara
name: Laube, Markus
name: Máthé, Domokos
name: Pályi, Bernadett
name: Hajdrik, Polett
name: Forgách, László
name: Kis, Zoltán
name: Szigeti, Krisztián
name: Bergmann, Ralf
name: Feldmann, Anja
name: Bachmann, Michael
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to millions of infections and deaths worldwide. As this virus evolves rapidly, there is a high need for treatment options that can win the race against new emerging variants of concern. Here, we describe a novel immunotherapeutic drug based on the SARS-CoV-2 entry receptor ACE2 and provide experimental evidence that it cannot only be used for (i) neutralization of SARS-CoV-2 in vitro and in SARS-CoV-2-infected animal models but also for (ii) clearance of virus-infected cells. For the latter purpose, we equipped the ACE2 decoy with an epitope tag. Thereby, we converted it to an adapter molecule, which we successfully applied in the modular platforms UniMAB and UniCAR for retargeting of either unmodified or universal chimeric antigen receptor-modified immune effector cells. Our results pave the way for a clinical application of this novel ACE2 decoy, which will clearly improve COVID-19 treatment.
Notes on morphological characteristics, genetic diversity and ethnobotanical uses for conservation of Citrus hongheensis (Rutaceae): an endemic and endangered Papeda from southwest China
Creators: name: Mou, Feng-Juan
name: Li, Jian-Qin
name: Gao, Yu-Hong
name: Li, Yue-Yan
name: Meng, Ting-Yao
name: Han, Shun-Long
Publisher: name: figshare
Year: 2023
Subjects: Other agricultural, veterinary and food sciences not elsewhere classified

description: Including three tables and six figures.
Two-photon polymerization of microneedles for transdermal drug delivery
Creators: name: Gittard, Shaun D
name: Doraiswamy, Anand
name: Ovsianikov, Aleksandr
name: Narayan, Roger J
name: Chichkov, Boris N
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Microneedles are small-scale devices that are finding use for transdermal delivery of protein-based pharmacologic agents and nucleic acid-based pharmacologic agents; however, microneedles prepared using conventional microelectronics-based technologies have several shortcomings, which have limited translation of these devices into widespread clinical use.
Linearized Non-Minimal Higher Curvature Supergravity
Creators: name: Farakos, Fotis
name: Kehagias, Alex
name: Koutrolikos, Konstantinos
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: In the framework of linearized non-minimal supergravity (20/20), we present the embedding of the $R + R^2$ model and we analyze its field spectrum. As usual, the auxiliary fields of the Einstein theory now become propagating, giving rise to additional degrees of freedom, which organize themselves into on-shell irreducible supermultiplets. By performing the analysis both in component and superspace formulations we identify the new supermultiplets. On top of the two massive chiral superfields reminiscent of the old-minimal supergravity embedding, the spectrum contains also a consistent physical, massive, vector supermultiplet and a tachyonic ghost, massive, vector supermultiplet.
Using molecular biology to develop drugs for renal cell carcinoma
Creators: name: Rathmell, W Kimryn
name: Cowey, C Lance
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Renal cell carcinoma is a disease marked by a unique biology which has governed it’s long history of poor response to conventional cancer treatments. The discovery of the signaling pathway activated as a result of inappropriate constitutive activation of the hypoxia inducible factors (HIF), transcription factors physiologically and transiently stabilized in response to low oxygen, has provided a primary opportunity to devise treatment strategies to target this oncogenic pathway.
An all-green photo-electrochemical biosensor using microalgae immobilized on eco-designed lignin-based screen-printed electrodes to detect sustainable nanoherbicides
Creators: name: Antonacci, Amina
name: Frisulli, Valeria
name: Carvalho, Lucas Bragança
name: Fraceto, Leonardo F.
name: Miranda, Bruno
name: Stefano, Luca
name: Johanningmeier, Udo
name: Giardi, Maria Teresa
name: Scognamiglio, Viviana
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 570

description: Herein, a novel completely green biosensor was designed exploiting both the biological and instrumental components made of eco-friendly materials for the detection of herbicides encapsulated into biodegradable nanoparticles for a sustainable agriculture. Similar nanocarriers, indeed, can deliver herbicides to the correct location, reducing the amount of active chemicals deposited in the plant, impacting the agricultural and food industries less. However, handling measurements of nanoherbicides is crucial to provide comprehensive information about their status in the agricultural fields to support farmers in decision-making. In detail, whole cells of the unicellular green photosynthetic alga Chlamydomonas reinhardtii UV180 mutant were immobilized by a green protocol on carbonized lignin screen-printed electrodes and integrated into a photo-electrochemical transductor for the detection of nanoformulated atrazine. Specifically, atrazine encapsulated into zein and chitosan doped poly-ε-caprolactone nanoparticles (atrazine-zein and atrazine-PCL-Ch) were analyzed following the current signals at a fixed applied potential of 0.8 V, in a range between 0.1 and 5 µM, indicating a linear relationship in the measured dose-response curves and a detection limit of 0.9 and 1.1 nM, respectively. Interference studies resulted in no interference from 10 ppb bisphenol A, 1 ppb paraoxon, 100 ppb arsenic, 20 ppb copper, 5 ppb cadmium, and 10 ppb lead at safety limits. Finally, no matrix effect was observed on the biosensor response from wastewater samples and satisfactory recovery values of 106 ± 8% and 93 ± 7% were obtained for atrazine-zein and atrazine-PCL-Ch, respectively. A working stability of 10 h was achieved.
Polarimetric modeling of corotating interaction regions (CIRs) threading massive-star winds
Creators: name: Ignace, R.
name: St-Louis, N.
name: Proulx-Giraldeau, F.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Massive star winds are complex radiation-hydrodynamic (sometimes magnetohydrodynamic) outflows that are propelled by their enormously strong luminosities. The winds are often found to be structured and variable, but can also display periodic or quasi-periodic behavior in a variety of wind diagnostics. The regular variations observed in putatively single stars, especially in UV wind lines, have often been attributed to corotating interaction regions (CIRs) like those seen in the solar wind. We present light curves for variable polarization from winds with CIR structures. We develop a model for a time-independent CIR based on a kinematical description. Assuming optically thin electron scattering, we explore the range of polarimetric light curves that result as the curvature, latitude, and number of CIRs are varied. We find that a diverse array of variable polarizations result from an exploration of cases. The net polarization from an unresolved source is weighted more toward the inner radii of the wind. Given that most massive stars have relatively fast winds compared to their rotation speeds, CIRs tend to be conical at inner radii, transitioning to a spiral shape at a few to several stellar radii in the wind. Winds with a single CIR structure lead to easily identifiable polarization signatures. By contrast allowing for multiple CIRs, all emerging from a range of azimuth and latitude positions at the star, can yield complex polarimetric behavior. Although our model is based on some simplifying assumptions, it produces qualitative behavior that we expect to be robust, and this has allowed us to explore a wide range of CIR configurations that will prove useful for interpreting polarimetric data.
description: accepted to A&A
Influence of nano-zinc oxide and fortified rice residue compost on rice productivity, zinc biofortification, zinc use efficiency, soil quality, zinc fractions and profitability in different rice production systems
Creators: name: Ramaiyan, Singaravel
name: Vijayakumar, Prabhu
name: Balasubramanian, Ramakichenin alias Balagandhi
name: Nallathambi, Mathivanan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: Transplanted rice (TPR) faces several limitations, including deteriorating soil quality, zinc (Zn) deficiency, low use efficiency of zinc sulfate (ZnSO4), water scarcity and escalating labor costs, which are dictating the shift toward alternate production systems like direct-sown rice (DSR) and aerobic rice (AR). However, this shift affects soil Zn dynamics and Zn availability to crops. This study was conducted to compare the effectiveness of Zn nutrition (ZnSO4 as soil application and zinc oxide nanoparticles (ZnO NPs) as seed priming alone or with foliar spray) and fortified organic manures (farm yard manure and rice residue) on the rice productivity, Zn use efficiency, grain biofortification, soil quality, Zn fractions and profitability under TPR, DSR and AR. The application of ZnO NPs and fortified rice residue compost significantly improved the yield traits (437 productive tillers m−2 and 186 filled grains panicle−1), grain weight (6.27 Mg ha−1), grain Zn fortification (33.41 mg kg−1) and Zn fractions in all rice production systems. The AR was found to be more encouraging in improving soil organic carbon (11.3%), dehydrogenase activity (21.96%), microbial biomass carbon (17.31%) and DTPA-Zn (10.57%) than TPR and DSR. ZnO NPs seed priming and fortified rice residue resulted in superior zinc use efficiency in both TPR and DSR. The maximum benefit-cost ratio was obtained in DSR with ZnO NPs and fortified rice residue compost. Altogether, DSR with seed priming and foliar spraying of ZnO NPs and fortified rice residue can be a more efficient way to enhance rice productivity, grain Zn fortification and profitability.
Recurrences and progression following microsurgery of vestibular schwannoma
Creators: name: Scheer, Maximilian
name: Simmermacher, Sebastian
name: Prell, Julian
name: Leisz, Sandra
name: Scheller, Christian
name: Mawrin, Christian
name: Strauss, Christian
name: Rampp, Stefan
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Background: The treatment approach of vestibular schwannoma (VS) has seen a change in recent years, with a trend away from radical surgery towards preservation of cranial nerve function. A recent study reported recurrences as long as 20 years after complete removal of VS. Objective: To report the risk of recurrence and progression in our patient population the authors retrospectively reviewed outcomes of patients. Methods: Cases with unilateral VS who had undergone primary microsurgery via retrosigmoidal approach between 1995 and 2021 were investigated. Complete tumor removal was defined as gross total resection (GTR), a capsular remnant was categorized as near total resection (NTR) and residual tumor was designated as subtotal resection (STR). The primary endpoint was radiological recurrence-free survival. Results: 386 patients fulfilled the inclusion criteria of the study and were evaluated. GTR was achieved in 284 patients (73.6%), NTR was achieved in 63 patients (10.1%) and STR was present in 39 patients (16.3%). A total of 28 patients experienced recurrences with significant differences in the three subgroups. The strongest predictor of recurrence was the extent of resection, with patients who underwent STR having an almost 10-fold higher risk of recurrence and patients who had undergone NTR having an almost 3-fold higher risk than those treated with GTR. More than 20% of recurrences (6/28) occured after more than 5 years. Conclusion: The degree of resection is an important guide to the interval of follow-up, but long-term follow-up should be considered also in the case of GTR. The majority of recurrences occurs after 3–5 years. Nevertheless, a follow-up of at least 10 years should be carried out.
Superconductive Ultra-compact Magnetically Coupled Resonator with Twin-spiral Structure
Creators: name: Averkin, A. S.
name: Zhuravel, A. P.
name: Karpov, A.
name: Anlage, S. M.
name: Ustinov, A. V.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We describe a practical design of an ultra-compact on-chip superconductive micro-resonator as a potential magnetic element of metamaterial. The achieved resonator size with respect to the wavelength in our experiment is about λ/ 14400. The resonator consists of two superconducting Nb spirals, sandwiched face to face, with a small gap filled with dielectric. The spirals are turning in opposite directions: one clockwise, another counter-clockwise. We study the resonator spectral response and its inner modes using numerical simulation in HFSS. In experiment with a Laser Scanning Microscope (LSM) we confirm the predictions for the resonance frequencies of Nb superconductive resonator and its inner modes structures. Small size and the ease of manufacturing make the two-spiral resonator an attractive solution for superconductive filters, coupling circuits, and as a magnetic component of a metamaterial.
description: 4 pages, 6 figures
Jammed Machines: The Novel in the Longue Durée of Cybernetics
Creators: name: Raden, Justin
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: Uncategorized

description: This dissertation attempts to trace the effects of media on literary production and literary critical discourse; in particular, on the novel. It does so not on the grounds that the novel absorbs forms from, responds to, or reacts against the proliferation of media, but takes a rather different approach. I argue instead that the encounter between literature and media is the defining constraint of the novel; the entanglement of the cultural practices of reading and writing and media technologies accounts for the adjudication of what can count as literature during the high period of the (predominantly Anglophone) novel in the second half of the nineteenth century through its modernist instantiation in the early twentieth. This account, then, vehemently rejects the language of “reaction” or “reflection” so often appended to accounts of (predominantly) modernist literary dispositions toward the late nineteenth and early twentieth century media and technological milieu. Instead I argue, drawing heavily on a combination of methodological approaches –– from what is sometimes called “media philosophy” or Kulturtechniken to deconstruction to Marxism –– that the development of the novel passes through the cultural techniques associated with alphabetic literacy which are also the discursive and technical conditions of not just possibility but indeed necessity of the development of media. I trace this history episodically, focusing on critical moments of transformation in both the practices and technologies of writing (broadly understood) and their reflection in exemplary literary texts.
Massive Primordial Black Holes from Hybrid Inflation as Dark Matter and the seeds of Galaxies
Creators: name: Clesse, Sébastien
name: García-Bellido, Juan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this paper we present a new scenario where massive Primordial Black Holes (PBH) are produced from the collapse of large curvature perturbations generated during a mild waterfall phase of hybrid inflation. We determine the values of the inflaton potential parameters leading to a PBH mass spectrum peaking on planetary-like masses at matter-radiation equality and producing abundances comparable to those of Dark Matter today, while the matter power spectrum on scales probed by CMB anisotropies agrees with Planck data. These PBH could have acquired large stellar masses today, via merging, and the model passes both the constraints from CMB distortions and micro-lensing. This scenario is supported by Chandra observations of numerous BH candidates in the central region of Andromeda. Moreover, the tail of the PBH mass distribution could be responsible for the seeds of supermassive black holes at the center of galaxies, as well as for ultra-luminous X-rays sources. We find that our effective hybrid potential can originate e.g. from D-term inflation with a Fayet-Iliopoulos term of the order of the Planck scale but sub-planckian values of the inflaton field. Finally, we discuss the implications of quantum diffusion at the instability point of the potential, able to generate a swiss-cheese like structure of the Universe, eventually leading to apparent accelerated cosmic expansion.
description: 17 pages, 5 figures, comments welcome