cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Product Line Annotations with UML-F
Creators: name: Pree, Wolfgang
name: Fontoura, Marcus
name: Rumpe, Bernhard
Publisher: name: arXiv
Year: 2014
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: The Unified Modeling Language (UML) community has started to define so-called profiles in order to better suit the needs of specific domains or settings. Product lines1 represent a special breed of systems they are extensible semi-finished pieces of software. Completing the semi-finished software leads to various software pieces, typically specific applications, which share the same core. Though product lines have been developed for a wide range of domains, they apply common construction principles. The intention of the UML-F profile (for framework architectures) is the definition of a UML subset, enriched with a few UML-compliant extensions, which allows the annotation of such artifacts. This paper presents aspects of the profile with a focus on patterns and exemplifies the profile's usage.
description: 10 pages, 9 figures
Additional file 3 of Factors influencing health workers’ compliance with the WHO intermittent preventive treatment for malaria in pregnancy recommendations in the Northern Region, Ghana
Creators: name: Mohammed, Abdul Gafaru
name: Duah, Dwomoh
name: Kenu, Ernest
name: Nonvignon, Justice
name: Manu, Alex
name: Bonful, Harriet Affran
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 3. Facility assessment.
Additional file 23 of Adiposity and mortality among intensive care patients with COVID-19 and non-COVID-19 respiratory conditions: a cross-context comparison study in the UK
Creators: name: Bell, Joshua A.
name: Carslake, David
name: Hughes, Amanda
name: Tilling, Kate
name: Dodd, James W.
name: Doidge, James C.
name: Harrison, David A.
name: Rowan, Kathryn M.
name: Davey Smith, George
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 23: Table S8 Associations of confounding/selection factors with all-cause mortality among ICU patients with non-COVID-19 respiratory conditions, by admission date
Evaluation of turbine film cooling holes designed for engine scale additive manufacturing
Creators: name: Furgeson, Michael Thomas
name: 0000-0001-7802-8001
Publisher: name: The University of Texas at Austin
Year: 2021
Subjects: Film cooling
Additive manufacturing

description: In recent years, it has become feasible to use additive manufacturing (AM) for gas turbine components, which allows novel turbine cooling designs such as rounded inlet film cooling holes. This thesis investigates the sensitivity of shaped holes designed for engine scale AM to internal roughness features produced during construction. In the study, two versions of a nominally 9-9-3 film cooling hole were evaluated with both “as-designed” and “as-built” configurations. The two 9-9-3 versions are an original rounded inlet hole as well as a rounded inlet and exit hole designed to minimize deformations that commonly occur with AM. Each hole configuration was constructed at engine scale using direct laser metal sintering (DMLS). The surfaces of these “as-built” geometries were characterized through computerized tomography (CT) scans. These scans were then used to build a scaled-up model of adiabatic and matched Biot number models, which were experimentally tested in a low speed wind tunnel to obtain adiabatic and overall cooling effectiveness data. In addition, computational predictions were performed for the rounded inlet, as-designed hole and compared to experimental data
Cooperative Roles for Fimbria and Filamentous Hemagglutinin in Bordetella Adherence and Immune Modulation
Creators: name: Cotter, Peggy A.
name: Scheller, Erich V.
name: Melvin, Jeffrey A.
name: Sheets, Amanda J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: ABSTRACTBordetella fimbriae (FIM) are generally considered to function as adhesins despite a lack of experimental evidence supporting this conclusion for Bordetella pertussis and evidence against a requirement for FIM in adherence of Bordetella bronchiseptica to mammalian cell lines. Using B.bronchiseptica and mice, we developed an in vivo adherence assay that revealed that FIM do function as critically important adhesins in the lower respiratory tract. In the first few days postinoculation, FIM-deficient B.bronchiseptica induced a more robust inflammatory response than wild-type bacteria did, suggesting that FIM, like filamentous hemagglutinin (FHA), allow B.bronchiseptica to suppress the innate immune response to infection. Localization analyses indicated that FIM are required for efficient attachment to airway epithelium, as bacteria lacking FIM localized to alveoli. FHA-deficient bacteria, in contrast, localized to airways. Bacteria unable to produce both FIM and FHA localized to alveoli and caused increased inflammation and histopathology identical to that caused by FIM-deficient bacteria, demonstrating that lack of FIM is epistatic to lack of FHA. Coinoculation experiments provided evidence that wild-type B.bronchiseptica suppresses inflammation locally within the respiratory tract and that both FHA and FIM are required for defense against clearance by the innate immune system. Altogether, our data suggest that FIM-mediated adherence to airway epithelium is a critical first step in Bordetella infection that allows FHA-dependent interactions to mediate tight adherence, suppression of inflammation, and resistance to inflammatory cell-mediated clearance. Our results suggest that mucosal antibodies capable of blocking FIM-mediated interactions could prevent bacterial colonization of the lower respiratory tract.IMPORTANCEAlthough fimbriae (FIM) have been shown to be important mediators of adherence for many bacterial pathogens, there is surprisingly little experimental evidence supporting this role for Bordetella fimbria. Our results provide the first demonstration that Bordetella FIM function as adhesins in vivo, specifically to airway epithelium. Furthermore, our results suggest that FIM mediate initial interactions with airway epithelial cells that are followed by tight filamentous hemagglutinin (FHA)-mediated binding and that together, FIM and FHA allow Bordetella to suppress inflammation, leading to prolonged colonization. Given the shortcoming of the current acellular component pertussis (aP) vaccine in preventing colonization, these findings suggest that generation of antibodies capable of blocking FIM-mediated adherence could potentially prevent Bordetella colonization.
Optically selected fossil groups; X-ray observations and galaxy properties
Creators: name: Khosroshahi, Habib G.
name: Gozaliasl, Ghassem
name: Rasmussen, Jesper
name: Molaeinezhad, Alireza
name: Ponman, Trevor
name: Dariush, Ali A.
name: Sanderson, Alastair J. R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We report on the X-ray and optical observations of galaxy groups selected from the 2dfGRS group catalog, to explore the possibility that galaxy groups hosting a giant elliptical galaxy and a large optical luminosity gap present between the two brightest group galaxies, can be associated with an extended X-ray emission, similar to that observed in fossil galaxy groups. The X-ray observations of 4 galaxy groups were carried out with Chandra telescope with 10-20 ksec exposure time. Combining the X-ray and the optical observations we find evidences for the presence of a diffuse extended X-ray emission beyond the optical size of the brightest group galaxy. Taking both the X-ray and the optical criteria, one of the groups is identified as a fossil group and one is ruled out because of the contamination in the earlier optical selection. For the two remaining systems, the X-ay luminosity threshold is close to the convention know for fossil groups. In all cases the X-ray luminosity is below the expected value from the X-ray selected fossils for a given optical luminosity of the group. A rough estimation for the comoving number density of fossil groups is obtained and found to be in broad agreement with the estimations from observations of X-ray selected fossils and predictions of cosmological simulations.
description: Accepted for publication in MNRAS
Enhanced Trapping of HIV-1 by Human Cervicovaginal Mucus Is Associated with Lactobacillus crispatus -Dominant Microbiota
Creators: name: Lai, Samuel K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: ABSTRACT Cervicovaginal mucus (CVM) can provide a barrier that precludes HIV and other sexually transmitted virions from reaching target cells in the vaginal epithelium, thereby preventing or reducing infections. However, the barrier properties of CVM differ from woman to woman, and the causes of these variations are not yet well understood. Using high-resolution particle tracking of fluorescent HIV-1 pseudoviruses, we found that neither pH nor Nugent scores nor total lactic acid levels correlated significantly with virus trapping in unmodified CVM from diverse donors. Surprisingly, HIV-1 was generally trapped in CVM with relatively high concentrations of d -lactic acid and a Lactobacillus crispatus -dominant microbiota. In contrast, a substantial fraction of HIV-1 virions diffused rapidly through CVM with low concentrations of d -lactic acid that had a Lactobacillus iners -dominant microbiota or significant amounts of Gardnerella vaginalis , a bacterium associated with bacterial vaginosis. Our results demonstrate that the vaginal microbiota, including specific species of Lactobacillus , can alter the diffusional barrier properties of CVM against HIV and likely other sexually transmitted viruses and that these microbiota-associated changes may account in part for the elevated risks of HIV acquisition linked to bacterial vaginosis or intermediate vaginal microbiota. IMPORTANCE Variations in the vaginal microbiota, especially shifts away from Lactobacillus -dominant microbiota, are associated with differential risks of acquiring HIV or other sexually transmitted infections. However, emerging evidence suggests that Lactobacillus iners frequently colonizes women with recurring bacterial vaginosis, raising the possibility that L. iners may not be as protective as other Lactobacillus species. Our study was designed to improve understanding of how the cervicovaginal mucus barrier against HIV may vary between women along with the vaginal microbiota and led to the finding that the vaginal microbiota, including specific species of Lactobacillus , can directly alter the diffusional barrier properties of cervicovaginal mucus. This work advances our understanding of the complex barrier properties of mucus and highlights the differential protective ability of different species of Lactobacillus , with Lactobacillus crispatus and possibly other species playing a key role in protection against HIV and other sexually transmitted infections. These findings could lead to the development of novel strategies to protect women against HIV.
Strategie per la valorizzazione dei centri storici minori nelle aree interne: proposte metodologiche
Creators: name: D'Andria, Emanuela
Publisher: name: Universita degli studi di Salerno
Year: 2021
Subjects: subject: ICAR/10 ARCHITETTURA TECNICA
subject: Centri minori
subject: Valorizzazione
subject: Analisi multicriterio

description: 2019 - 2020
description: The will to face the issue of small towns in inland areas comes from the awareness of the importance of these realities for the sustainable development of territories. There is a growing need to establish valorization strategies with a broad and multi-disciplinary approach, covering the built heritage matters, but also social, cultural, environmental and economic problems. Moreover, it is fundamental to consider or-ganic actions that go beyond punctual operations on a single building. In this regard, it may be useful to set up operational tools in order to support local governments and stakeholders in choosing the most effective interventions to be taken in these scopes. The small realities are extremely complex and characterized by a vast material and immaterial heritage difficult to understand, manage and protect. Although there are many researches, studies and bibliographical references on the subject, there is no investigation in the literature that includes the use of multi-criteria analysis models for the selection of the most valid enhancement actions to be carried out in small municipalities, as well as for the specific detection of the weaknesses of the strategies already implemented. In view of these considerations, the research goal is the valorization of small towns to be pursued through the development of a multi-criteria tool aimed at directing the decision-maker – local government and/or stakeholders – in the evaluation of the efficacy of the actions carried out. Such a tool can help in quickly understanding the critical issues and promote targeted improvements for the right regeneration and en-hancement of the place. The aforementioned purpose is feasible because multi-criteria models allow making convenience judgments about specific interventions based on multiple factors. In fact, the multi-criteria analysis (MCDA) supports the decision-maker in solving complex problems that pose heterogeneous and conflicting issues. This leads to com-promise solutions that balance the pursuit of established goals with a view to max-imizing collective well-being and environmental protection. In light of the topic’s specificity, due to the coexistence of multiple factors, it was decided to examine the subject in the following areas: architectural-landscape, eco-nomic, sociological, environmental... [edited by Author]
Genetic Diversity in the Collaborative Cross Model Recapitulates Human West Nile Virus Disease Outcomes
Creators: name: Suthar, Mehul S.
name: Ferris, Martin T.
name: Gale, Michael
name: Ireton, Renee
name: Graham, Jessica B.
name: Lund, Jennifer M.
name: McMillan, Aimee A.
name: Swarts, Jessica
name: Treuting, Piper M.
name: Thomas, Sunil
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: ABSTRACTWest Nile virus (WNV) is an emerging neuroinvasive flavivirus that now causes significant morbidity and mortality worldwide. The innate and adaptive immune responses to WNV infection have been well studied in C57BL/6J inbred mice, but this model lacks the variations in susceptibility, immunity, and outcome to WNV infection that are observed in humans, thus limiting its usefulness to understand the mechanisms of WNV infection and immunity dynamics. To build a model of WNV infection that captures human infection outcomes, we have used the Collaborative Cross (CC) mouse model. We show that this model, which recapitulates the genetic diversity of the human population, demonstrates diversity in susceptibility and outcomes of WNV infection observed in humans. Using multiple F1 crosses of CC mice, we identified a wide range of susceptibilities to infection, as demonstrated through differences in survival, clinical disease score, viral titer, and innate and adaptive immune responses in both peripheral tissues and the central nervous system. Additionally, we examined the Oas1b alleles in the CC mice and confirmed the previous finding that Oas1b plays a role in susceptibility to WNV; however, even within a given Oas1b allele status, we identified a wide range of strain-specific WNV-associated phenotypes. These results confirmed that the CC model is effective for identifying a repertoire of host genes involved in WNV resistance and susceptibility. The CC effectively models a wide range of WNV clinical, virologic, and immune phenotypes, thus overcoming the limitations of the traditional C57BL/6J model, allowing genetic and mechanistic studies of WNV infection and immunity in differently susceptible populations.IMPORTANCEMouse models of West Nile virus infection have revealed important details regarding the innate and adaptive immune responses to this emerging viral infection. However, traditional mouse models lack the genetic diversity present in human populations and therefore limit our ability to study various disease outcomes and immunologic mechanisms subsequent to West Nile virus infection. In this study, we used the Collaborative Cross mouse model to more effectively model the wide range of clinical, virologic, and immune phenotypes present upon West Nile virus infection in humans.
The set of space-filling curves: topological and algebraic structure
Creators: name: Bernal-González, L.
name: Calderón-Moreno, M. C.
name: Prado-Bassas, J. A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Topology (math.GN)
subject: FOS: Mathematics
subject: 15A03, 20M05, 46E15, 54E40, 54F15

description: In this paper, a study of topological and algebraic properties of two families of functions from the unit interval $I$ into the plane $\mathbb{R}^2$ is performed. The first family is the collection of all Peano curves, that is, of those continuous mappings onto the unit square. The second one is the bigger set of all space-filling curves, i.e. of those continuous functions $I \to \mathbb{R}^2$ whose images have positive Jordan content. Emphasis is put on the size of these families, in both topological and algebraic senses, when endowed with natural structures.
Additional file 19 of Adiposity and mortality among intensive care patients with COVID-19 and non-COVID-19 respiratory conditions: a cross-context comparison study in the UK
Creators: name: Bell, Joshua A.
name: Carslake, David
name: Hughes, Amanda
name: Tilling, Kate
name: Dodd, James W.
name: Doidge, James C.
name: Harrison, David A.
name: Rowan, Kathryn M.
name: Davey Smith, George
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 19: Table S4 Associations of confounding/selection factors with BMI among ICU patients with non-COVID-19 respiratory conditions, by admission date
Эффективность комплексного подхода к терапии сахарного диабета типа 2
Creators: name: Алимова Галия Умяровна
Publisher: name: Эндокринология: Новости. Мнения. Обучение
Year: 2017
Subjects: КОМПЛЕКСНОЕ МНОГОФАКТОРНОЕ УПРАВЛЕНИЕ
САХАРНЫЙ ДИАБЕТ ТИПА 2
АНТИОКСИДАНТНАЯ ТЕРАПИЯ
ОКСИДАТИВНЫЙ СТРЕСС
ГЛЮКОЗОЛИПОТОКСИЧНОСТЬ
INTEGRATED MULTIFACTORIAL MANAGEMENT
TYPE 2 DIABETES MELLITUS
ANTIOXIDANT THERAPY
OXIDATIVE STRESS
GLUCOSOLIPOTOXICITY

description: Использование комплексного подхода в лечении сахарного диабета типа 2 (СД2) приводит к улучшению показателей гликемического и липидного контроля, тем самым к снижению глюкозои липотоксичности, уменьшению уровня оксидативного стресса, положительной динамике массы тела. Антиоксидантная терапия является патогенетической по отношению к формированию осложнений у пациентов с СД2, в связи с чем активно изучаются препараты природные антиоксиданты, в частности глюкоберри, который показал высокую эффективность в качестве дополнительной метаболической терапии в комплексном управлении СД2.The use of integrated approach in the treatment of type 2 diabetes mellitus (DM2) leads to improved glycemic and lipid control, by that reducing glucose and lipotoxicity, reducing oxidative stress, and improving body weight. Antioxidant therapy is pathogenetic in relation to the development of complications in patients with DM2, in connection with which the active substances are studied -natural antioxidants, in particular "Glukoberry", which showed high efficiency as an additional metabolic therapy in the integrated management of type 2 diabetes.
Additional file 1 of Evaluating sensitivity to classification uncertainty in latent subgroup effect analyses
Creators: name: Loh, Wen Wei
name: Kim, Jee-Seon
Publisher: name: figshare
Year: 2022
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Additional file 1: Supplementary Material.
A Review on Non-Minimal Universal Extra Dimensions
Creators: name: Flacke, Thomas
name: Kong, Kyoungchul
name: Park, Seong Chan
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We report on the current status of non-minimal universal extra dimension (UED) models. Our emphasis is on the possible extension of the minimal UED model by allowing bulk masses and boundary localized terms. We take into account the data from the Large Hadron Collider as well as direct and indirect searches of dark matter and electroweak precision measurements.
description: 14 pages, invited review on non-minimal universal extra dimensions to appear in Modern Physics Letters A
Glycolytic Dependency of High-Level Nitric Oxide Resistance and Virulence in Staphylococcus aureus
Creators: name: Richardson, Anthony R.
name: Spahich, Nicole A.
name: Vitko, Nicholas P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: ABSTRACTStaphylococcus aureus is a prolific human pathogen capable of causing severe invasive disease with a myriad of presentations. The ability of S.aureus to cause infection is strongly linked with its capacity to overcome the effects of innate immunity, whether by directly killing immune cells or expressing factors that diminish the impact of immune effectors. One such scenario is the induction of lactic acid fermentation by S.aureus in response to host nitric oxide (NO·). This fermentative activity allows S.aureus to balance redox during NO·-induced respiration inhibition. However, little is known about the metabolic substrates and pathways that support this activity. Here, we identify glycolytic hexose catabolism as being essential for S.aureus growth in the presence of high levels of NO·. We determine that glycolysis supports S.aureus NO· resistance by allowing for ATP and precursor metabolite production in a redox-balanced and respiration-independent manner. We further demonstrate that glycolysis is required for NO· resistance during phagocytosis and that increased levels of extracellular glucose limit the effectiveness of phagocytic killing by enhancing NO· resistance. Finally, we demonstrate that S.aureus glycolysis is essential for virulence in both sepsis and skin/soft tissue models of infection in a time frame consistent with the induction of innate immunity and host NO· production.IMPORTANCEStaphylococcusaureus is a leading human bacterial pathogen capable of causing a wide variety of diseases that, as a result of antibiotic resistance, are very difficult to treat. The frequency of S.aureus tissue invasion suggests that this bacterium has evolved to resist innate immunity and grow using the nutrients present in otherwise sterile host tissue. We have identified glycolysis as an essential component of S.aureus virulence and attribute its importance to promoting nitric oxide resistance and growth under low oxygen conditions. Our data suggest that diabetics, a patient population characterized by excess serum glucose, may be more susceptible to S.aureus as a result of increased glucose availability. Furthermore, the essential nature of S.aureus glycolysis indicates that a newly developed glycolysis inhibitor may be a highly effective treatment for S.aureus infections.
Additional file 21 of Adiposity and mortality among intensive care patients with COVID-19 and non-COVID-19 respiratory conditions: a cross-context comparison study in the UK
Creators: name: Bell, Joshua A.
name: Carslake, David
name: Hughes, Amanda
name: Tilling, Kate
name: Dodd, James W.
name: Doidge, James C.
name: Harrison, David A.
name: Rowan, Kathryn M.
name: Davey Smith, George
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 21: Table S6 Associations of confounding/selection factors with all-cause mortality among ICU patients with COVID-19, by admission date
Avoided Valence Transition in a Plutonium Superconductor
Creators: name: Ramshaw, B. J.
name: Shekhter, A.
name: McDonald, R. D.
name: Betts, J. B.
name: Mitchell, J. N.
name: Tobash, P. H.
name: Mielke, C. H.
name: Bauer, E. D.
name: Migliori, A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Some of the most remarkable phenomena---and greatest theoretical challenges---in condensed matter physics arise when $d$ or $f$ electrons are neither fully localized around their host nuclei, nor fully itinerant. This localized/itinerant "duality" underlies the correlated electronic states of the high-$T_c$ cuprate superconductors and the heavy-fermion intermetallics, and is nowhere more apparent than in the $5f$ valence electrons of plutonium. Here we report the full set of symmetry-resolved elastic moduli of $PuCoGa_5$---the highest $T_c$ superconductor of the heavy fermions ($T_c$=18.5 K)---and find that the bulk modulus softens anomalously over a wide range in temperature above $T_c$. Because the bulk modulus is known to couple strongly to the valence state, we propose that plutonium valence fluctuations drive this elastic softening. This elastic softening is observed to disappear when the superconducting gap opens at $T_c$, suggesting that plutonium valence fluctuations have a strong footprint on the Fermi surface, and that $PuCoGa_5$ avoids a valence-transition by entering the superconducting state. These measurements provide direct evidence of a valence instability in a plutonium compound, and suggest that the unusually high-$T_c$ in this system is driven by valence fluctuations.
description: 4 figures
СУҒОРИШ МИҚДОРИ БИЛАН ТУПРОҚНИНГ ШЎРЛАНГАНЛИГИ ВА ЗИЧЛИГИ ОРАСИДАГИ БОҒЛИҚЛИКНИ АНИҚЛАШ БЎЙИЧА ТАЖРИБА НАТИЖАЛАРИ
Creators: name: Мамбетназаров, Е.Б.
name: Атаниязов, А.С.
name: Бердикеев, Б.Б.
Publisher: name: Zenodo
Year: 2023

description: Суғориладиган майдонларда шўр ювишда суғориш меъёри 4000-5000 м3/га бўлганда тупроқ таркибидаги умумий тузлар миқдорини суғориш меъёрига  боғлиқ равишда  0,446-0,498 % гача ва хлор миқдорини  0,0275-0,030 % гача камайтириб, кучсиз шўрланиш даражасига келтиришга эришиш мумкин.
Paesaggi d’acqua. Il fenomeno del termalismo nel comprensorio euganeo tra antichità ed età moderna
Creators: name: Zanovello, Paola;Meleri, Andrea
Publisher: name: La Rivista di Engramma
Year: 2023
Subjects: Thermalism
Euganean Hills
Water Landscapes

description: Thermalism in the Euganean area has been known and exploited for millennia, but today the interests, including economic ones, are concentrated in particular in the area between Abano and Montegrotto Terme, where there are important remains from the Roman era. However, the phenomenon is much wider and more widespread in the territory and deserves adequate valorisation, also because in the less known and frequented areas the thermal water landscape better preserves its original characteristics and lends itself to tourist and cultural promotion actions.
In Vivo Transcriptional Profiling of Yersinia pestis Reveals a Novel Bacterial Mediator of Pulmonary Inflammation
Creators: name: Goldman, William E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: ABSTRACTInhalation of Yersinia pestis results in primary pneumonic plague, a highly lethal and rapidly progressing necrotizing pneumonia. The disease begins with a period of extensive bacterial replication in the absence of disease symptoms, followed by the sudden onset of inflammatory responses that ultimately prove fatal. Very little is known about the bacterial and host factors that contribute to the rapid biphasic progression of pneumonic plague. In this work, we analyzed the in vivo transcription kinetics of 288 bacterial open reading frames previously shown by microarray analysis to be dynamically regulated in the lung. Using this approach combined with bacterial genetics, we were able to identify five Y.pestis genes that contribute to the development of pneumonic plague. Deletion of one of these genes, ybtX, did not alter bacterial survival but attenuated host inflammatory responses during late-stage disease. Deletion of ybtX in another lethal respiratory pathogen, Klebsiella pneumoniae, also resulted in diminished host inflammation during infection. Thus, our in vivo transcriptional screen has identified an important inflammatory mediator that is common to two Gram-negative bacterial pathogens that cause severe pneumonia.IMPORTANCEYersiniapestis is responsible for at least three major pandemics, most notably the Black Death of the Middle Ages. Due to its pandemic potential, ease of dissemination by aerosolization, and a history of its weaponization, Y.pestis is categorized by the Centers for Disease Control and Prevention as a tier 1 select agent most likely to be used as a biological weapon. To date, there is no licensed vaccine against Y.pestis. Importantly, an early “silent” phase followed by the rapid onset of nondescript influenza-like symptoms makes timely treatment of pneumonic plague difficult. A more detailed understanding of the bacterial and host factors that contribute to pathogenesis is essential to understanding the progression of pneumonic plague and developing or enhancing treatment options.
Maximally Supersymmetric AdS4 Vacua in N=4 Supergravity
Creators: name: Louis, Jan
name: Triendl, Hagen
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study AdS backgrounds of N=4 supergravity in four space-time dimensions which preserve all sixteen supercharges. We show that the graviphotons have to form a subgroup of the gauge group that consists of an electric and a magnetic SO(3)_+ x SO(3)_-. Moreover, these N=4 AdS backgrounds are necessarily isolated points in field space which have no moduli.
description: 11 pages
Additional file 15 of Adiposity and mortality among intensive care patients with COVID-19 and non-COVID-19 respiratory conditions: a cross-context comparison study in the UK
Creators: name: Bell, Joshua A.
name: Carslake, David
name: Hughes, Amanda
name: Tilling, Kate
name: Dodd, James W.
name: Doidge, James C.
name: Harrison, David A.
name: Rowan, Kathryn M.
name: Davey Smith, George
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 15: Figure S15 Association between BMI and mortality in COVID-19 and non-COVID-19 respiratory patients, by geographical region.
Additional file 1 of Posttraumatic growth inventory: challenges with its validation among French cancer patients
Creators: name: Dubuy, Yseulys
name: Sébille, Véronique
name: Bourdon, Marianne
name: Hardouin, Jean-Benoit
name: Blanchin, Myriam
Publisher: name: figshare
Year: 2022
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Additional file 1.
Нарушения репродуктивной функции у мужчин после комплексного лечения медуллобластомы
Creators: name: Бобков Даниил Николаевич
Publisher: name: Эндокринология: Новости. Мнения. Обучение
Year: 2017
Subjects: МЕДУЛЛОБЛАСТОМА
МУЖСКОЕ РЕПРОДУКТИВНОЕ ЗДОРОВЬЕ
ДЕТСКИЙ И ПОДРОСТКОВЫЙ ВОЗРАСТ
ВЗРОСЛЫЙ ВОЗРАСТ
КОМПЛЕКСНОЕ ЛЕЧЕНИЕ ОБРАЗОВАНИЙ ГОЛОВНОГО МОЗГА
NEUROGLIOCYTOMA
MALE REPRODUCTIVE HEALTH
CHILDHOOD AND ADOLESCENCE
ADULT AGE
COMPLEX TREATMENT OF BRAIN FORMATIONS

description: Изучена структура и клинико-лабораторные характеристики репродуктивных нарушений у мужчин, получавших комплексную терапию по поводу медуллобластомы (МБ). Установлено, что у мужчин после терапии МБ крайне высока распространенность нарушений репродуктивной системы, особенно выраженные нарушения развиваются при проведении лечения в детском и подростковом возрасте.The structure and clinico-laboratorial characteristics of reproductive disorders in men who received complex therapy for neurogliocytoma were investigated. It was found that after therapy for neurogliocytoma in men, prevalence of reproductive system disorders is extremely high, especially severe disorders develop during treatment in childhood and adolescence.
Agricultural Income and Purchasing Power
Creators: name: Stine, O. C.
name: Stine, O. C.
Publisher: name: Unknown
Year: 1934
Subjects: Agricultural Finance
Crop Production/Industries
Demand and Price Analysis
Financial Economics
Livestock Production/Industries

description: Excerpt: The gross income from agriculture for the 1934 season, probably will be about $7,200,000,000, compared with about $6,300,000,000 for 1933 and $3,300,000,000 for 1932, the low point in the depression. This is an increase of 36 percent in 2 years. Cash income will probably increase from $4,370,000,000 to about $6,200,000,000, an increase of $1,830,000,000 or 42 percent. Rental and benefit payments made material contributions to this increase, amounting to $271,000,000 in 1933 and about $589,000,000 in 1934. The actual position of the farm operator has been improved more than is indicated by these figures. A 3-year period, 1930-32, in which income was insufficient to pay all expenses and farm-hand wages to the operator, has now been followed by 2 years of income sufficient to return something to the operator for his management and capital. The income to farm operators from 1934 production, for labor, capital, and management, after paying expenses, probably would purchase about twice the quantity of the goods that could be bought by that for 1932.
description: Address, Joint Session, American Statistical Association, and American Farm Economic Association, Chicago, Dec. 28, 1934 devoted to discussions of the topic Changes in the Aggregate Volume and Distribution of Purchasing Power During Recovery. By O. C. Stine, Principal Agricultural Economist, In Charge, Division of Statistical and Historical Research, Bureau of Agricultural Economics
Показатели углеводного обмена у работников локомотивных бригад железнодорожного транспорта, работающих в ночные смены
Creators: name: Гариева Майя Акакиевна
Publisher: name: Эндокринология: Новости. Мнения. Обучение
Year: 2017
Subjects: САХАРНЫЙ ДИАБЕТ
РАБОТНИКИ ЛОКОМОТИВНЫХ БРИГАД
СТРЕССОУСТОЙЧИВОСТЬ
ГЛИКИРОВАННЫЙ ГЕМОГЛОБИН
НОЧНЫЕ СМЕНЫ
DIABETES MELLITUS
WORKERS OF LOCOMOTIVE BRIGADES
STRESS RESISTANCE
HBA1C LEVEL
NIGHT SHIFTS

description: Сахарный диабет типа 2 является социально значимым заболеванием, увеличивающим риски инвалидизации и смертности трудоспособного населения. Распространенность сахарного диабета неуклонно растет, в связи с чем все большее значение приобретают вопросы его профилактики и своевременное выявление факторов риска его развития. В последние время большое внимание уделяется нарушениям сна как одному из факторов, оказывающих влияние на углеводный обмен. Так, в Великобритании проводилось исследовани, по данным которого ночная работа увеличивает риск диабета на 9%. Это вызвано плохим питанием и нарушением метаболизма из-за сбоя внутренних часов. Однако вопрос взаимосвязи работы в ночные смены и развития нарушений углеводного обмена, ранней диагностики этих нарушений, а также достижения эффективного контроля гликемии у данной когорты пациентов остается открытым.Diabetes mellitus type 2 is a socially significant disease that increases the risk of development of disability and mortality of the able-bodied population. The prevalence of diabetes mellitus is steadily increasing, so that the importance of its prevention becomes more important, the timely detection of risk factors for its occurrence. In recent times, much attention is paid to sleep disturbances, as one of the factors affecting the carbohydrate metabolism. So in the UK, a study was conducted, according to which night work increases the risk of diabetes by 9%. This is caused by poor diet and metabolic disorders due to a malfunction of the internal clock. However, the issue of the relationship of work to night shifts and the development of carbohydrate metabolism disorders, the early diagnosis of these disorders, and the achievement of effective glycemic control in this cohort of patients remains open.
Kaposi’s Sarcoma-Associated Herpesvirus Interleukin-6 Modulates Endothelial Cell Movement by Upregulating Cellular Genes Involved in Migration
Creators: name: Giffin, Louise
name: Damania, Blossom
name: West, John A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: ABSTRACT Kaposi’s sarcoma-associated herpesvirus (KSHV) is the causative agent of human Kaposi’s sarcoma, a tumor that arises from endothelial cells, as well as two B cell lymphoproliferative diseases, primary effusion lymphoma and multicentric Castleman’s disease. KSHV utilizes a variety of mechanisms to evade host immune responses and promote cellular transformation and growth in order to persist for the life of the host. A viral homolog of human interleukin-6 (hIL-6) named viral interleukin-6 (vIL-6) is encoded by KSHV and expressed in KSHV-associated cancers. Similar to hIL-6, vIL-6 is secreted, but the majority of vIL-6 is retained within the endoplasmic reticulum, where it can initiate functional signaling through part of the interleukin-6 receptor complex. We sought to determine how intracellular vIL-6 modulates the host endothelial cell environment by analyzing vIL-6’s impact on the endothelial cell transcriptome. vIL-6 significantly altered the expression of many cellular genes associated with cell migration. In particular, vIL-6 upregulated the host factor carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) at the protein and message levels. CEACAM1 has been implicated in tumor invasion and metastasis and promotes migration and vascular remodeling in endothelial cells. We report that vIL-6 upregulates CEACAM1 by a STAT3-dependent mechanism and that CEACAM1 promotes vIL-6-mediated migration. Furthermore, latent and de novo KSHV infections of endothelial cells also induce CEACAM1 expression. Collectively, our data suggest that vIL-6 modulates endothelial cell migration by upregulating the expression of cellular factors, including CEACAM1. IMPORTANCE Kaposi’s sarcoma-associated herpesvirus (KSHV) is linked with the development of three human malignancies, Kaposi’s sarcoma, multicentric Castleman’s disease, and primary effusion lymphoma. KSHV expresses many factors that enable the virus to manipulate the host environment in order to persist and induce disease. The viral interleukin-6 (vIL-6) produced by KSHV is structurally and functionally homologous to the human cytokine interleukin-6, except that vIL-6 is secreted slowly and functions primarily from inside the host cell. To investigate the unique intracellular role of vIL-6, we analyzed the impact of vIL-6 on endothelial cell gene expression. We report that vIL-6 significantly alters the expression of genes associated with cell movement, including that for CEACAM1. The gene for CEACAM1 was upregulated by vIL-6 and by latent and primary KSHV infection and promotes vIL-6-mediated endothelial cell migration. This work advances the field’s understanding of vIL-6 function and its contribution to KSHV pathogenesis.
Knockout of Epstein-Barr Virus BPLF1 Retards B-Cell Transformation and Lymphoma Formation in Humanized Mice
Creators: name: Montgomery, Stephanie A.
name: Su, Lishan
name: Pagano, Joseph S.
name: Montgomery, Nathan D.
name: Li, Guangming
name: Whitehurst, Christopher B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: ABSTRACT BPLF1 of Epstein-Barr virus (EBV) is classified as a late lytic cycle protein but is also found in the viral tegument, suggesting its potential involvement at both initial and late stages of viral infection. BPLF1 possesses both deubiquitinating and deneddylating activity located in its N-terminal domain and is involved in processes that affect viral infectivity, viral DNA replication, DNA repair, and immune evasion. A recently constructed EBV BPLF1-knockout (KO) virus was used in conjunction with a humanized mouse model that can be infected with EBV, enabling the first characterization of BPLF1 function in vivo . Results demonstrate that the BPLF1-knockout virus is approximately 90% less infectious than wild-type (WT) virus. Transformation of human B cells, a hallmark of EBV infection, was delayed and reduced with BPLF1-knockout virus. Humanized mice infected with EBV BPLF1-knockout virus showed less weight loss and survived longer than mice infected with equivalent infectious units of WT virus. Additionally, splenic tumors formed in 100% of mice infected with WT EBV but in only 25% of mice infected with BPLF1-KO virus. Morphological features of spleens containing tumors were similar to those in EBV-induced posttransplant lymphoproliferative disease (PTLD) and were almost identical to cases seen in human diffuse large B-cell lymphoma. The presence of EBV genomes was detected in all mice that developed tumors. The results implicate BPLF1 in human B-cell transformation and tumor formation in humanized mice. IMPORTANCE Epstein-Barr virus infects approximately 90% of the world’s population and is the causative agent of infectious mononucleosis. EBV also causes aggressive lymphomas in individuals with acquired and innate immune disorders and is strongly associated with diffuse large B-cell lymphomas, classical Hodgkin lymphoma, Burkitt lymphoma, and nasopharyngeal carcinoma (NPC). Typically, EBV initially infects epithelial cells in the oropharynx, followed by a lifelong persistent latent infection in B-cells, which may develop into lymphomas in immunocompromised individuals. This work is the first of its kind in evaluating the effects of EBV’s BPLF1 in terms of pathogenesis and lymphomagenesis in humanized mice and implicates BPLF1 in B-cell transformation and tumor development. Currently, there is no efficacious treatment for EBV, and therapeutic targeting of BPLF1 may lead to a new path to treatment for immunocompromised individuals or transplant recipients infected with EBV.
New Insight into Filamentous Hemagglutinin Secretion Reveals a Role for Full-Length FhaB in Bordetella Virulence
Creators: name: Melvin, Jeffrey A.
name: Noël, Christopher R.
name: Scheller, Erich V.
name: Cotter, Peggy A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: ABSTRACTBordetella filamentous hemagglutinin (FHA), a primary component of acellular pertussis vaccines, contributes to virulence, but how it functions mechanistically is unclear. FHA is first synthesized as an ~370-kDa preproprotein called FhaB. Removal of an N-terminal signal peptide and a large C-terminal prodomain (PD) during secretion results in “mature” ~250-kDa FHA, which has been assumed to be the biologically active form of the protein. Deletion of two C-terminal subdomains of FhaB did not affect production of functional FHA, and the mutant strains were indistinguishable from wild-type bacteria for their ability to adhere to the lower respiratory tract and to suppress inflammation in the lungs of mice. However, the mutant strains, which produced altered FhaB molecules, were eliminated from the lower respiratory tract much faster than wild-type B.bronchiseptica, suggesting a defect in resistance to early immune-mediated clearance. Our results revealed, unexpectedly, that full-length FhaB plays a critical role in B.bronchiseptica persistence in the lower respiratory tract.IMPORTANCEThe Bordetella filamentous hemagglutinin (FHA) is a primary component of the acellular pertussis vaccine and an important virulence factor. FHA is initially produced as a large protein that is processed during secretion to the bacterial surface. As with most processed proteins, the mature form of FHA has been assumed to be the functional form of the protein. However, our results indicate that the full-length form plays an essential role in virulence in vivo. Furthermore, we have found that FHA contains intramolecular regulators of processing and that this control of processing is integral to its virulence activities. This report highlights the advantage of studying protein maturation and function simultaneously, as a role for the full-length form of FHA was evident only from in vivo infection studies and not from in vitro studies on the production or maturation of FHA or even from in vitro virulence-associated activity assays.
Применение препаратов а-липоевой кислоты у больных сахарным диабетом типа 2 с диабетической полинейропатией
Creators: name: Горшков Иван Петрович
name: Волынкина Анна Петровна
Publisher: name: Эндокринология: Новости. Мнения. Обучение
Year: 2017
Subjects: САХАРНЫЙ ДИАБЕТ
ДИАБЕТИЧЕСКАЯ ПОЛИНЕЙРОПАТИЯ
А-ЛИПОЕВАЯ КИСЛОТА
ОКСИДАТИВНЫЙ СТРЕСС
DIABETES MELLITUS
DIABETIC POLYNEUROPATHY
ALPHA-LIPOIC ACID
OXIDATIVE STRESS

description: Оценивали клинико-лабораторную эффективность а-липоевой кислоты (АЛК) у больных сахарным диабетом типа 2 (СД2) с диабетической полинейропатией (ДПН). Под наблюдением находились 59 больных СД2 с ДПН: 27 (45,8%) женщин и 32 (54,2%) мужчины. 30 пациентов дополнительно получали внутривенно 600 мг АЛК в день в течение 14 дней. В группе получавших АЛК в сравнении с контрольной группой общая оксидативная способность сыворотки крови, уровень антител IgG к окисленным липопротеинам низкой плотности (MDA-LDLdgG) снизились на 13,9% (Д-0,5) и 12,9% (А-45,8) соответственно, а общая антиоксидантная способность сыворотки крови увеличилась на 27,3% (А+29,4) (U, p<0,05), что отразилось на субъективных и объективных проявлениях ДПН: индекс TSS ниже на 11,6% (А-1,1), NDS на 9,1% (А-1,5), DN4 на 14,3% (А-0,9) (U, p<0,05).CLinicaL and Laboratory efficacy of а-Lipoic acid (ALA) in type 2 diabetes meLLitus (DM2) patients with diabetic poLyneuropathy (DPN) was evaLuated. There were 59 DM2 patients with DPN under observation: 27 (45.8%) women and 32 (54.2%) men. 30 patients were additionaLLy treated with iv 600 mg of ALA daiLy for 14 days. TotaL serum oxidative capacity and LeveL of IgG antibodies to oxidized Low-density Lipoprotein (MDA-LDLc IgG) decreased by 13.9% (Д-0.5) and 12.9% (Д-45.8) respectiveLy in ALA-treated group compared with controL group and totaL serum antioxidant capacity increased by 27.3% (Д+ 29.4) (U, p <0.05), which affected DPN subjective and objective manifestations: TSS index is Lower by 11.6% (Д-1.1), NDS by 9.1% (Д-1.5), DN4 by 14.3% (Д-0.9) (U, p<0.05).