cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 3 of Prevalence and risk factors for laminitis within the Norwegian pony breed Nordlandshest/Lyngshest
Creators: name: Lykkjen, Sigrid
name: Stenbakk, Linda Koldal
name: Holmøy, Ingrid Hunter
Publisher: name: figshare
Year: 2023
Subjects: subject: Neuroscience
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 3: Distribution across counties. The table displays the distribution across counties for all horses registered in the Norwegian breed association for Nordlandshest/lyngshestin 2019, and the NL study-population.
title: Gene Expression Regulation in the Mouse Liver by Mechanistic Target Of Rapamycin Complexes I and II
Creators: name: Poluyanoff, Anthony
Publisher: name: University of Massachusetts Amherst
Year: 2020

description: The mechanistic target of rapamycin (mTOR) is a key serine/threonine protein kinase that functions in complexes mTORC1 and mTORC2. mTORC1, originally discovered due to its sensitivity towards the mTOR inhibitor rapamycin, responds to extracellular growth factor signaling, WNT signaling, and nutrient abundance via glucose and amino acid-triggered signaling. Downstream effectors of mTORC1 include autophagy, mitochondrial metabolic function, protein synthesis, and ribosome biogenesis. mTORC2, initially discovered as a rapamycin-insensitive complex of mTOR, responds to insulin, growth factor signaling, and inflammatory signaling such as tumor necrosis factor-alpha, with its downstream effectors being Akt, a key serine/threonine kinase that functions in cell division and is frequently dysregulated in many types of cancer, the NFkB pathway, and cytoskeletal reorganization and protein synthesis. Much research has been devoted to mTORC1 signaling, with mTORC2 receiving significantly less attention, despite both complexes’ regulation of key cellular activities and response to rapamycin, as well as to other rapamycin-derived drugs (rapalogs). We have targeted both mTORC1 and mTORC2 for hepatocyte-specific deletion during the gestational period of mice, with the goal of describing mTORC1 and mTORC2 signaling and its perturbation in the adult mouse hepatocyte. Our model has shown that deletion of RAPTOR, the regulatory associated protein of mTOR, and RICTOR, the rapamycin insensitive component of mTOR, in mTORC1 and mTORC2 respectively, leads to widespread effects on the hepatocyte transcriptome. We have found that a subset of genes responds both to Raptor and Rictor knockout, and an analysis of these genes indicates their function in key disorders of the liver, such as non-alcoholic fatty liver disease and hepatocellular carcinoma. Bioinformatic analysis following hepatocyte RNA sequencing of mTORC1 and mTORC2 knockout mice has revealed an unexpected upregulation of genes known to be regulated by these respective complexes. We have also found that cross talk exists between both complexes, in which the knockout of one yields the activation of the other. We have additionally found translationally relevant enrichments following Ingenuity Pathway Analysis (IPA) of RNA sequencing data. These results provide a key mechanistic discovery of mTOR signaling activity, and allow for a better understanding of the potential physiological effects of mTOR inhibition in human patients.
Additional file 1 of Immune phenotype of patients with stage IV metastatic inflammatory breast cancer
Creators: name: Fernandez, Sandra V.
name: MacFarlane, Alexander W.
name: Mowafaq Jillab
name: Arisi, Maria F.
name: Yearley, Jennifer
name: Lakshmanan Annamalai
name: Yulan Gong
name: Cai, Kathy Q.
name: R. Katherine Alpaugh
name: Cristofanilli, Massimo
name: Campbell, Kerry S.
Publisher: name: figshare
Year: 2020
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1.
TIP49b, a Regulator of Activating Transcription Factor 2 Response to Stress and DNA Damage
Creators: name: Ivanov, Vladimir N.
name: Ronai, Ze'ev
name: Cho, Ssang-Goo
name: Bhoumik, Anindita
name: Rosenstein, Barry
name: Broday, Limor
Publisher: name: Columbia University
Year: 2001
Subjects: Apoptosis
Transcription factors
Cytology
Molecular biology

description: Activating transcription factor 2 (ATF2/CRE-BP1) is implicated in transcriptional control of stress-responsive genes. A yeast two-hybrid screen identified TBP-interacting protein 49b (TIP49b), a component of the INO80 chromatin-remodeling complex, as a novel ATF2-interacting protein. TIP49b's association with ATF2 is phosphorylation dependent and requires amino acids 150 to 248 of ATF2 (ATF2150–248), which are implicated in intramolecular inhibition of ATF2 transcriptional activities. Forced expression of TIP49b efficiently attenuated ATF2 transcriptional activities under normal growth conditions as well as after UV treatment, ionizing irradiation, or activation of p38 kinase, all of which induced ATF2 phosphorylation and increased TIP49b-ATF2 association. Constitutive expression of ATF2150–248 peptide outcompeted TIP49b interaction with ATF2 and alleviated the suppression of ATF2 transcriptional activities. Expression of ATF2150–248 in fibroblasts or melanoma but not in ATF2-null cells caused a profound G2M arrest and increased degree of apoptosis following irradiation. The interaction between ATF2 and TIP49b constitutes a novel mechanism that serves to limit ATF2 transcriptional activities and highlights the central role of ATF2 in the control of the cell cycle and apoptosis in response to stress and DNA damage.
Consistent Compactification of Double Field Theory on Non-geometric Flux Backgrounds
Creators: name: Hassler, Falk
name: Lust, Dieter
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this paper, we construct non-trivial solutions to the $2D$-dimensional field equations of Double Field Theory (DFT) by using a consistent Scherk-Schwarz ansatz. The ansatz identifies $2(D-d)$ internal directions with a twist $U^M{}_N$ which is directly connected to the covariant fluxes $\mathcal{F}_{ABC}$. It exhibits $2(D-d)$ linear independent generalized Killing vectors $K_I{}^J$ and gives rise to a gauged supergravity in $d$ dimensions. We analyze the covariant fluxes and the corresponding gauged supergravity with a Minkowski vacuum. We calculate fluctuations around such vacua and show how they gives rise to massive scalars field and vectors field with a non-abelian gauge algebra. Because DFT is a background independent theory, these fields should directly correspond the string excitations in the corresponding background. For $(D-d)=3$ we perform a complete scan of all allowed covariant fluxes and find two different kinds of backgrounds: the single and the double elliptic case. The later is not T-dual to a geometric background and cannot be transformed to a geometric setting by a field redefinition either. While this background fulfills the strong constraint, it is still consistent with the Killing vectors depending on the coordinates and the winding coordinates, thereby giving a non-geometric patching. This background can therefore not be described in Supergravity or Generalized Geometry.
description: 44 pages, 3 tables, references added, typos corrected
title: A Cross-Sectional Study of Phthalate Exposure and Inflammation Biomarker Levels Among Postmenopausal Women
Creators: name: Trim, Avery
Publisher: name: University of Massachusetts Amherst
Year: 2020

description: Phthalates are industrial chemicals added to plastics found in products such as children’s toys, cosmetics, and household items, and some laboratory studies suggest phthalates may increase levels of inflammation. Chronic inflammation is associated with many chronic health conditions, such as diabetes and rheumatoid arthritis. Although research is limited, recent studies suggest a strong positive relationship between mono-butyl phthalate (MBP), mono-isobutyl phthalate (MiBP), and monocarboxynonyl phthalate (MCNP) and c-reactive protein (CRP), as well as monoethyl phthalate (MEP) and mono-3-carboxypropyl phthalate (MCPP) and interleukin-6 (IL-6). Additionally, this relationship has not been examined among postmenopausal women, a population that is at higher risk of developing chronic health conditions. Our aim was to examine the association between urinary phthalate biomarkers and inflammation biomarkers among postmenopausal women using baseline data from a subset of participants of the Women’s Health Initiative (WHI) (n=443). Phthalate exposure was assessed using phthalate biomarkers (i.e. phthalate metabolites or their molar sum) from urine samples collected at WHI clinical centers from 1993-1998. We measured 13 phthalate metabolites: MEP, MBP, mono-hydroxybutyl phthalate (MHBP), MiBP, mono-hydroxyisobutyl phthalate (MHiBP), monobenzyl phthalate (MBzP), MCPP, mono (2-ethylhexyl) phthalate (MEHP), mono (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono (2-ethyl-5-oxohexyl) phthalate (MEOHP), mono (2-ethyl-5-carboxypentyl) phthalate (MECPP), mono-carboxyoctyl phthalate (MCOP), and MCNP. Serum and plasma inflammatory biomarker levels (i.e. CRP, IL-6) were measured in separate WHI ancillary studies, using blood samples collected at baseline. We used multivariable linear regression to analyze associations between each phthalate biomarker and inflammation biomarker, adjusting for important covariates. Phthalate biomarkers MCNP (Model 1: b = 0.523; Model 2: b = 0.362) and MCOP (Model 1: b = 0.384; Model 2: b = 0.240) were positively associated with CRP. Additionally, MCNP (Model 1: b = 0.369; Model 2: b = 0.181) was positively associated with IL-6. Statistically significant associations were not observed among the remaining phthalate biomarkers. Our findings suggest that certain phthalates may be related to increasing levels of inflammation.
Jun NH2-Terminal Kinase Phosphorylation of p53 on Thr-81 Is Important for p53 Stabilization and Transcriptional Activities in Response to Stress
Creators: name: Ivanov, Vladimir N.
name: Buschmann, Thomas
name: Potapova, Olga
name: Bar-Shira, Anat
name: Fuchs, Serge Y.
name: Henderson, Scott
name: Fried, Victor A.
name: Minamoto, Toshinari
name: Alarcon-Vargas, Dania
name: Pincus, Matthew R.
name: Gaarde, William A.
name: Holbrook, Nikki J.
name: Shiloh, Yosef
name: Ronai, Ze'ev
Publisher: name: Columbia University
Year: 2001
Subjects: Tumor suppressor proteins
Apoptosis
Cytology
Molecular biology

description: The p53 tumor suppressor protein plays a key role in the regulation of stress-mediated growth arrest and apoptosis. Stress-induced phosphorylation of p53 tightly regulates its stability and transcriptional activities. Mass spectrometry analysis of p53 phosphorylated in 293T cells by active Jun NH2-terminal kinase (JNK) identified T81 as the JNK phosphorylation site. JNK phosphorylated p53 at T81 in response to DNA damage and stress-inducing agents, as determined by phospho-specific antibodies to T81. Unlike wild-type p53, in response to JNK stimuli p53 mutated on T81 (T81A) did not exhibit increased expression or concomitant activation of transcriptional activity, growth inhibition, and apoptosis. Forced expression of MKP5, a JNK phosphatase, in JNK kinase-expressing cells decreased T81 phosphorylation while reducing p53 transcriptional activity and p53-mediated apoptosis. Similarly transfection of antisense JNK 1 and -2 decreased T81 phosphorylation in response to UV irradiation. More than 180 human tumors have been reported to contain p53 with mutations within the region that encompasses T81 and the JNK binding site (amino acids 81 to 116). Our studies identify an additional mechanism for the regulation of p53 stability and functional activities in response to stress.
Dynamics and Conductivity Near Quantum Criticality
Creators: name: Gazit, Snir
name: Podolsky, Daniel
name: Auerbach, Assa
name: Arovas, Daniel P.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Relativistic O(N) field theories are studied near the quantum critical point in two space dimensions. We compute dynamical correlations by large scale Monte Carlo simulations and numerical analytic continuation. In the ordered side, the scalar spectral function exhibits a universal peak at the Higgs mass. For N=3 and 4 we confirm its ω^3 rise at low frequency. On the disordered side, the spectral function exhibits a sharp gap. For N=2, the dynamical conductivity rises above a threshold at the Higgs mass (density gap), in the superfluid (Mott insulator) phase. For charged bosons, (Josephson arrays) the power law rise above the Higgs mass, increases from two to four. Approximate charge-vortex duality is reflected in the ratio of imaginary conductivities on either side of the transition. We determine the critical conductivity to be σ^*_c = 0.3 (\pm 0.1) 4e^2/h. In the appendices, we describe a generalization of the worm algorithm to N>2, and also a singular value decomposition error analysis for the numerical analytic continuation.
description: 17 pages, 17 figures, revised appendix B, additional references added, corrected typos
title: Die unterzeichneten, im Königreich Hannover zur deutschen Nationalversammlung gewählten Abgeordenten, haben das Schreiben, welches das Königlich Hannoversche Gesammtministerium unterm 7. d. M. an die jetzt vertagte Hannoversche Ständeversammlung gerichtet hat, welches dieser Erklärung anliegt,mit der Aufmerksamkeit geprüft, welche dessen Inhalt erheischt. ...; [1848]
title: Frankfurt a. M., den 12. Juli 1848
titleType: Subtitle
Creators: name: Lang, Friedrich
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2018

description: Enth. als Beilage: Schreiben des Königlichen Gesammt-Ministerii vom 7. Julius 1848
Elevated Serum Carboxymethyl-Lysine, an Advanced Glycation End Product, Predicts Severe Walking Disability in Older Women: The Women's Health and Aging Study I
Creators: name: Sun, Kai
name: Semba, Richard D.
name: Fried, Linda P.
name: Schaumberg, Debra A.
name: Ferrucci, Luigi
name: Varadhan, Ravi
Publisher: name: Columbia University
Year: 2012
Subjects: Walking--Physiological aspects
Older women
Epidemiology
Aging

description: Advanced glycation end products (AGEs) have been implicated in the pathogenesis of sarcopenia. Our aim was to characterize the relationship between serum carboxymethyl-lysine (CML), a major circulating AGE, and incident severe walking disability (inability to walk or walking speed < 0 . 4  m/sec) over 30 months of followup in 394 moderately to severely disabled women, ≥ 6 5 years, living in the community in Baltimore, Maryland (the Women’s Health and Aging Study I). During followup, 154 (26.4%) women developed severe walking disability, and 23 women died. Women in the highest quartile of serum CML had increased risk of developing of severe walking disability in a multivariate Cox proportional hazards model, adjusting for age and other potential confounders. Women with elevated serum CML are at an increased risk of developing severe walking disability. AGEs are a potentially modifiable risk factor. Further work is needed to establish a causal relationship between AGEs and walking disability.
British Columbia Legislative Assembly sessional clipping book (1932-03)
Creators: name: :Unav
Publisher: name: University of Victoria Libraries
Year: 2022
Subjects: subject: Law
valueUri: http://id.worldcat.org/fast/993678
subject: FOS: Law
subject: Politics and government
valueUri: http://id.worldcat.org/fast/1919741
subject: British Columbia. Legislative Assembly
valueUri: http://id.worldcat.org/fast/600765

description: These Sessional Clippings books cover the period 1891 to 1972, and include newspaper accounts written by various legislative reporters who covered debates occurring in the British Columbia Legislative Assembly. Transcripts of debates of the Legislative Assembly (Hansard) were not published in B.C. until 1970; hence these "Sessional Clipping Books" augment the "Journals", the record of daily proceedings of the Legislative Assembly. Selected clippings from various newspapers including the Vancouver Sun, the Vancouver Province, the Colonist, and the Times newspapers, relating to the newspaper reports concerning activities of the Legislature. The original sessional clippings books comprise 351 ledger size print volumes, held at the Legislative Library in Victoria BC. The print volumes were microfilmed onto 26 reels in 1977 under a Tri University Libraries (TRIUL) project by Precision Micrographic Services (Vancouver, B.C.), with the permission of the Legislative Library, Victoria, British Columbia. This digital collection was created by scanning the 26 microfilm reels.
Additional file 2 of Prevalence and risk factors for laminitis within the Norwegian pony breed Nordlandshest/Lyngshest
Creators: name: Lykkjen, Sigrid
name: Stenbakk, Linda Koldal
name: Holmøy, Ingrid Hunter
Publisher: name: figshare
Year: 2023
Subjects: subject: Neuroscience
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2: Causal diagram for laminitis.
Additional file 5 of Mapping and understanding the decision-making process for providing nutrition and hydration to people living with dementia: a systematic review
Creators: name: Anantapong, Kanthee
name: Davies, Nathan
name: Chan, Justin
name: McInnerney, Daisy
name: Sampson, Elizabeth L.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 5:. Overall judgements of quality assessment.docx
Y Chromosomes of 40% Chinese Are Descendants of Three Neolithic Super-grandfathers
Creators: name: Yan, Shi
name: Wang, Chuan-Chao
name: Zheng, Hong-Xiang
name: Wang, Wei
name: Qin, Zhen-Dong
name: Wei, Lan-Hai
name: Wang, Yi
name: Pan, Xue-Dong
name: Fu, Wen-Qing
name: He, Yun-Gang
name: Xiong, Li-Jun
name: Jin, Wen-Fei
name: Li, Shi-Lin
name: An, Yu
name: Li, Hui
name: Jin, Li
Publisher: name: arXiv
Year: 2013
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: Genomics (q-bio.GN)
subject: FOS: Biological sciences

description: Demographic change of human populations is one of the central questions for delving into the past of human beings. To identify major population expansions related to male lineages, we sequenced 78 East Asian Y chromosomes at 3.9 Mbp of the non-recombining region (NRY), discovered >4,000 new SNPs, and identified many new clades. The relative divergence dates can be estimated much more precisely using molecular clock. We found that all the Paleolithic divergences were binary; however, three strong star-like Neolithic expansions at ~6 kya (thousand years ago) (assuming a constant substitution rate of 1e-9/bp/year) indicates that ~40% of modern Chinese are patrilineal descendants of only three super-grandfathers at that time. This observation suggests that the main patrilineal expansion in China occurred in the Neolithic Era and might be related to the development of agriculture.
description: 29 pages of article text including 1 article figure, 9 pages of SI text, and 2 SI figures. 5 SI tables are in a separate ancillary file
Financial Strain Is Associated with Malnutrition Risk in Community-Dwelling Older Women
Creators: name: Samuel, Laura J.
name: Szanton, Sarah L.
name: Weiss, Carlos O.
name: Thorpe, Roland J.
name: Semba, Richard D.
name: Fried, Linda P.
Publisher: name: Columbia University
Year: 2012
Subjects: Finance, Personal
Malnutrition
Older women
Epidemiology
Aging
Nutrition

description: This study examined the relationship between financial strain, or difficulty acquiring necessities, and malnutrition risk in a community dwelling sample of frail and nonfrail women aged 70-79 in the Women’s Health and Aging Study (n = 679). Malnutrition risk was measured with a modified version of the Mini-Nutritional Assessment Short Form (MNA-SF) and defined as a score < 11, financial strain was measured by (1) sufficiency of money on a monthly basis and (2) adequacy of income for food, and income was measured by ordinal categories. Mean (SD) modified MNA-SF score was 12.2 (1.80), and 14.7% of women had malnutrition risk. Women who usually did not have enough money to make ends meet had more than four-fold increased odds of malnutrition risk (OR = 4.54; 95% CI: 2.26, 9.14) compared to their counterparts who had some money left over each month. This was only slightly attenuated after control for income and education, (OR = 4.08; 95% CI: 1.95, 8.52) remaining robust. These results show an association between financial strain and malnutrition risk, independent of income, in older women. Self-reported financial strain may be preferable to income as a screener for malnutrition risk in older adults in clinical and research settings.
Using Process Calculus for Optimizing Data and Computation Sharing in Complex Stateful Parallel Computations
Creators: name: Tian, Zilu
name: Olteanu, Dan
name: Koch, Christoph
Publisher: name: arXiv
Year: 2025
Subjects: subject: Databases (cs.DB)
subject: FOS: Computer and information sciences

description: We propose novel techniques that exploit data and computation sharing to improve the performance of complex stateful parallel computations, like agent-based simulations. Parallel computations are translated into behavioral equations, a novel formalism layered on top of the foundational process calculus $π$-calculus. Behavioral equations blend code and data, allowing a system to easily compose and transform parallel programs into specialized programs. We show how optimizations like merging programs, synthesizing efficient message data structures, eliminating local messaging, rewriting communication instructions into local computations, and {aggregation pushdown} can be expressed as transformations of behavioral equations. We have also built a system called OptiFusion that implements behavioral equations and the aforementioned optimizations. Our experiments showed that OptiFusion is over 10$\times$ faster than state-of-the-art stateful systems benchmarked via complex stateful workloads. Generating specialized instructions that are impractical to write by hand allows OptiFusion to outperform even the hand-optimized implementations by up to 2$\times$.
description: To appear on SIGMOD'25
Propagation of coupled quartic and dipole multi-solitons in optical fibers medium with higher-order dispersions
Creators: name: Kruglov, Vladimir I.
name: Triki, Houria
Publisher: name: arXiv
Year: 2023
Subjects: subject: Pattern Formation and Solitons (nlin.PS)
subject: FOS: Physical sciences

description: We present the discovery of two types of multiple-hump soliton modes in a highly dispersive optical fiber with a Kerr nonlinearity. We show that multi-hump optical solitons of quartic or dipole types are possible in the fiber system in the presence of higher-order dispersion. Such nonlinear wave packets are very well described by an extended nonlinear Schrodinger equation involving both cubic and quartic dispersion terms. It is found that the third- and fourth-order dispersion effects in the fiber material may lead to the coupling of quartic or dipole solitons into double-, triple-, and multi-humped solitons. We provide the initial conditions for the formation of coupled multi-hump quartic and dipole solitons in the fiber. Numerical results illustrate that propagating multi-quartic and multi-dipole solitons in highly dispersive optical fibers councide with a high accuracy to our analytical multi-soliton solutions. It is important for applications that described multiple-hump soliton modes are stable to small noise perturbation that was confirmed by numerical simulations. These numerical results confirm that the newly found multi-soliton pulses can be potentially utilized for transmission in optical fibers medium with higher-order dispersions.
description: 6 pages, 6 figures
title: The Ecological Value of Spruce Plantations in Massachusetts
Creators: name: Ritter, Calvin
Publisher: name: University of Massachusetts Amherst
Year: 2020

description: The establishment of monoculture plantations of exotic tree species is common practice for supplementing native timber stocks. Such plantations typically provide inferior habitat for wildlife compared to native forest, which may result in a net reduction in biodiversity. However, some studies report that plantations may increase net biodiversity at the landscape scale by introducing novel habitats or supplementing existing natural forests. Using point count surveys, I examined six mature Norway spruce (Picea abies) plantations in western Massachusetts in 2016 and 2017 to evaluate bird use of these habitats relative to native forest stands. Count data were analyzed using N-mixture models to correct for imperfect detection, providing more accurate estimates of true abundance. Our findings showed that overall species richness for spruce plantations was not significantly lower than that of native forest habitats. Red-breasted nuthatch (Sitta canadensis) and golden-crowned kinglet (Regulus satrapa) were most abundant in spruce plantations. Conifer dependent species such as Blackburnian warbler (Setophaga fusca) and brown creeper (Certhia americana), were significantly more abundant in spruce plantations relative to native deciduous, hemlock, and mixed stands. Species that heavily associate with broadleaf habitat were rarely observed in spruce plantations. Species that associate with eastern hemlock habitat, such as Blue-headed vireo (Vireo solitarious) and black-throated green warbler (Setophaga virens) were observed using spruce plantations at similar levels as eastern hemlock stands. These results demonstrate that Norway spruce plantations can provide suitable habitat for native species associated with conifers, which is significant given projected continued decline of eastern hemlock in response to the hemlock wooly adelgid (Adelges tsugae). Although large-scale conversion of native forest to plantations would likely lead to a loss in biodiversity, land managers could be justified in allowing small-scale plantations to persist without suffering negative impacts to native biodiversity.
Additional file 3 of A COVID-19 call center for healthcare providers: dealing with rapidly evolving health policy guidelines
Creators: name: Aharona Glatman-Freedman
name: Bromberg, Michal
name: Ram, Amit
name: Lutski, Miri
name: Bassal, Ravit
name: Michailevich, Olga
name: Saban, Mor
name: Frankental, Dvora
name: Dichtiar, Rita
name: Kruglikov-Moldavsky, Anna
name: Rozani, Violetta
name: Dolev Karolinsky
name: Braun, Tali
name: Zuker, Inbar
name: Keinan-Boker, Lital
name: Silverman, Barbara G.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 3: Supplemental Table S3. The most common calls content in each call category.
Exploration of walking speed prediction: a data-driven approach
Creators: name: Wood, Andrew
Publisher: name: The University of Edinburgh
Year: 2023
Subjects: walking speed
fixed variables
walking slope
gradient
terrain obstruction
GPS data
environmental factors

description: Hikers and hillwalkers typically use the gradient in the direction of travel (walking slope) as the main variable in established methods for predicting walking speeds along a route. Research into fell-running has suggested further variables which impact speed in this context. Recent improvements in data availability, as well as widespread use of GPS tracking now make it possible to test these variables on a large scale. Here we tested various models used to predict walking speed against public GPS data from almost 93,000 km of UK walking / hiking tracks. Tracks were filtered to remove breaks and non-walking sections. A generalised linear model (GLM) was found to be most accurate at determining walking speeds. Key differences between the GLM and commonly used rules were that the GLM considered the gradient of the terrain (hill slope) irrespective of walking slope, as well as the terrain type and level of terrain obstruction in off-road travel. All of these factors were shown to be highly significant, and this is supported by a lower root-mean-square-error compared to existing functions, particularly in the areas where the majority of travel occurs. We also noted an increase in RMSE between the GLM and established methods as hill slope increases, further exemplifying the importance of this variable. As well as providing a new walking speed formula, the underlying dataset can be used in future work to test alternate models.
Additional file 4 of Prevalence and risk factors for laminitis within the Norwegian pony breed Nordlandshest/Lyngshest
Creators: name: Lykkjen, Sigrid
name: Stenbakk, Linda Koldal
name: Holmøy, Ingrid Hunter
Publisher: name: figshare
Year: 2023
Subjects: subject: Neuroscience
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 4: Univariate analyses. The table displays the number of observations, odds ratio, 95% confidence intervalsand P-values for factors associated with outcomewith P<0.2, based on univariable testing using logistic regression.
Echoes of multiple outbursts of Sagittarius A* revealed by Chandra
Creators: name: Clavel, Maïca
name: Terrier, R.
name: Goldwurm, A.
name: Morris, M. R.
name: Ponti, G.
name: Soldi, S.
name: Trap, G.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The relatively rapid spatial and temporal variability of the X-ray radiation from some molecular clouds near the Galactic center shows that this emission component is due to the reflection of X-rays generated by a source that was luminous in the past, most likely the central supermassive black hole, Sagittarius A*. Studying the evolution of the molecular cloud reflection features is therefore a key element to reconstruct Sgr A*'s past activity. The aim of the present work is to study this emission on small angular scales in order to characterize the source outburst on short time scales. We use Chandra high-resolution data collected from 1999 to 2011 to study the most rapid variations detected so far, those of clouds between 5' and 20' from Sgr A* towards positive longitudes. Our systematic spectral-imaging analysis of the reflection emission, notably of the Fe Kalpha line at 6.4 keV and its associated 4-8 keV continuum, allows us to characterize the variations down to 15" angular scale and 1-year time scale. We reveal for the first time abrupt variations of few years only and in particular a short peaked emission, with a factor of 10 increase followed by a comparable decrease, that propagates along the dense filaments of the Bridge cloud. This 2-year peaked feature contrasts with the slower 10-year linear variations we reveal in all the other molecular structures of the region. Based on column density constraints, we argue that these two different behaviors are unlikely to be due to the same illuminating event. The variations are likely due to a highly variable active phase of Sgr A* sometime within the past few hundred years, characterized by at least two luminous outbursts of a few-year time scale and during which the Sgr A* luminosity went up to at least 10^39 erg/s.
description: 17 pages, 16 figures, Accepted for publication in Astronomy & Astrophysics
British Columbia Legislative Assembly sessional clipping book (1932-04)
Creators: name: :Unav
Publisher: name: University of Victoria Libraries
Year: 2022
Subjects: subject: Politics and government
valueUri: http://id.worldcat.org/fast/1919741
subject: British Columbia. Legislative Assembly
valueUri: http://id.worldcat.org/fast/600765
subject: Law
valueUri: http://id.worldcat.org/fast/993678
subject: FOS: Law

description: These Sessional Clippings books cover the period 1891 to 1972, and include newspaper accounts written by various legislative reporters who covered debates occurring in the British Columbia Legislative Assembly. Transcripts of debates of the Legislative Assembly (Hansard) were not published in B.C. until 1970; hence these "Sessional Clipping Books" augment the "Journals", the record of daily proceedings of the Legislative Assembly. Selected clippings from various newspapers including the Vancouver Sun, the Vancouver Province, the Colonist, and the Times newspapers, relating to the newspaper reports concerning activities of the Legislature. The original sessional clippings books comprise 351 ledger size print volumes, held at the Legislative Library in Victoria BC. The print volumes were microfilmed onto 26 reels in 1977 under a Tri University Libraries (TRIUL) project by Precision Micrographic Services (Vancouver, B.C.), with the permission of the Legislative Library, Victoria, British Columbia. This digital collection was created by scanning the 26 microfilm reels.
Infection with the Intracellular Protozoan Parasite Theileria parva Induces Constitutively High Levels of NF-κ B in Bovine T Lymphocytes.
Creators: name: Ivanov, Vladimir N.
name: Stein, Bernd
name: Baumann, Ina
name: Dobbelaere, Dirk A. E.
name: Herrlich, Peter
name: Williams, Richard O.
Publisher: name: Columbia University
Year: 1989
Subjects: T cells
Cytology
Molecular biology

description: The intracellular protozoan parasite Theileria parva causes a lymphoproliferative disease of T cells in cattle and uncontrolled lymphocyte proliferation in culture. We have identified and characterized in infected cells the transcriptional activator, NF-κ B, whose recognition motifs have been identified in several gene enhancers important for lymphocyte-specific gene expression. NF-κ B is normally constitutively activated in nuclear extracts derived from B cells and can be induced in T cells and nonlymphoid cells by phorbol esters. Theileria-infected lymphocytes contained constitutively high levels of activated NF-kappa B in nuclear fractions and inactive NF-κ B in cytoplasmic fractions. The inactive cytoplasmic precursor could be activated by treatment of extracts with deoxycholate, which was shown previously to dissociate NF-κ B from an inhibitor, I kappa B. Treatment of lymphocyte extracts with 3 mM GTP stimulated NF-κ B binding to its recognition motif in vitro, thereby distinguishing it from a related nuclear factor, H2-TF1. Selective killing of the parasite, which left the host cells intact, resulted in a rapid loss of NF-κ B from the nuclear fractions and a slower loss from the cytoplasmic fractions. In parasitized cells, NF-κ B could not be further stimulated by treatment with 12-O-tetradecanoylphorbol-13-acetate whereas in cells treated to remove the parasite, this compound stimulated elevated levels of NF-κ B. We propose that high levels of activated NF-κ B are maintained by the presence of the parasite in infected T cells. Similarly, we propose that the high levels of inactive cytoplasmic precursor are a result of increased synthesis due to the presence of the parasite.
title: The Association between Dengue Virus Infection and Liver and Kidney Function among Cambodian Children
Creators: name: Moineau, Ashley
Publisher: name: University of Massachusetts Amherst
Year: 2020

description: Severe liver and kidney dysfunction are prevalent in 10%-30% of the Southeast Asian population. Dengue virus infection has been reported as a modifiable risk factor for liver and kidney dysfunction, especially among children in Southeast Asia. Epidemiologic studies assessing this relationship are sparse, often failed to include children, and did not adjust for important covariates. Therefore, we evaluated the relationship between dengue virus infection and liver and kidney dysfunction among hospitalized children in Cambodia (n=551). Participants with a serologically confirmed dengue virus infection were categorized according to increasing severity of infection (i.e. dengue fever, dengue hemorrhagic fever, or dengue shock syndrome) using clinical assessment. Laboratory assays were used to assess liver (i.e. albumin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total protein) and kidney protein levels (i.e. creatinine and urea). Descriptive statistics were used to assess the impact of severity of dengue virus infection on kidney dysfunction. Additionally, descriptive statistics and linear mixed modeling were used to assess the impact of severity of dengue virus infection on liver dysfunction while adjusting for important risk factors. Approximately 75% of all participants had abnormal liver or kidney protein level(s) over the first four days of follow-up. Overall, a negative association was observed between increasing dengue disease severity and albumin (ßadj = -0.08, 95% CI = -0.45 to 0.29), ALT (ßadj = -18.02, 95% CI = -51.59 to 15.55), and AST (ßadj = -7.18, 95% CI = -49.57 to 35.21) protein levels. A positive association was observed between increasing dengue disease severity and total protein levels (ßadj = 7.14, 95% CI = 1.15 to 13.13). While abnormal liver function (increases in ALT and/or AST levels and decreases in albumin and/or total protein levels) is a common clinical finding in dengue infections, we did not find evidence for a significant association with more severe forms of dengue virus infection (i.e. dengue hemorrhagic fever or dengue shock syndrome) and greater liver dysfunction as compared to patients with dengue fever in pediatric populations in Cambodia.
title: An den Präsidenten der constituirenden Nationalversammlung; [1848]
title: Nürnberg, 2. Juli 1848
titleType: Subtitle
Creators: name: Andrian-Werburg, Victor ¬von
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2018

description: Kopftitel. - Denkschrift. - Namen der Unterzeichneten: Andrian, Victor von ; Jucho,Friedrich S. ; Raveaux, Franz ; Franke, Carl ; Saucken, ... von ; Rotenhahn, Hermann ; Heckscher, Johann G.
Pinning down the primordial black hole formation mechanism with gamma-rays and gravitational waves
Creators: name: Xie, Ke-Pan
Publisher: name: arXiv
Year: 2023
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Primordial black holes (PBHs) are predicted in many models via different formation mechanisms. Identifying the origin of PBHs is of the same importance as probing their existence. We propose to probe the asteroid-mass PBHs [$\mathcal{O}(10^{17})~{\rm g}\lesssim M\lesssim\mathcal{O}(10^{22})~{\rm g}$] with gamma-rays from Hawking radiation and the stochastic gravitational waves (GWs) from the early Universe. We consider four concrete formation mechanisms, including collapse from primordial curvature perturbations, first-order phase transitions, or cosmic strings, and derive the extended PBH mass functions of each mechanism for phenomenological study. The results demonstrate that by combining gamma-rays and GW signals we can probe PBHs up to $\mathcal{O}(10^{19})~{\rm g}$ and identify their physical origins.
description: 18 pages + references. 10 figures and 1 table. To appear on JCAP
Additional file 2 of A COVID-19 call center for healthcare providers: dealing with rapidly evolving health policy guidelines
Creators: name: Aharona Glatman-Freedman
name: Bromberg, Michal
name: Ram, Amit
name: Lutski, Miri
name: Bassal, Ravit
name: Michailevich, Olga
name: Saban, Mor
name: Frankental, Dvora
name: Dichtiar, Rita
name: Kruglikov-Moldavsky, Anna
name: Rozani, Violetta
name: Dolev Karolinsky
name: Braun, Tali
name: Zuker, Inbar
name: Keinan-Boker, Lital
name: Silverman, Barbara G.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 2: Supplemental Table S2. Categories of questions raised by callers to the ICDC call center (N=6,933).
TNF-α Is the Critical Mediator of the Cyclic AMP-Induced Apoptosis of CD8+4+ Double-Positive Thymocytes
Creators: name: Ivanov, Vladimir N.
name: Nikolić-Žugić, Janko
name: Guevara Patiño, José A.
name: Lacy, Elizabeth
name: Elkon, Keith B.
name: Marino, Michael W.
Publisher: name: Columbia University
Year: 2000
Subjects: subject: T cells
subject: Apoptosis
subject: Immunology
subject: FOS: Clinical medicine
subject: Cytology

description: Apoptosis is one of the key regulatory mechanisms in tissue modeling and development. In the thymus, 95–98% of all thymocytes die by apoptosis because they failed to express a TCR with an optimal affinity for the selecting intrathymic peptide-MHC complexes. We studied the possible role of two prominent nerve growth factor (NGF-TNF) family member systems, Fas ligand (FasL)-Fas receptor (FasR) and TNF-α-TNFR, in apoptosis of murine CD8+4+ double-positive (DP) thymocytes induced via TCR-CD3- and cAMP-mediated signaling. TCR-CD3ε-mediated apoptosis of DP thymocytes was found not to be dependent on either of the two systems. The FasL-FasR system was also found to be dispensable for the cAMP-mediated apoptosis. By contrast, cAMP agonists (dibutyryl-cAMP and forskolin) induced apoptosis via TNF-α, as evidenced by 1) the ability of anti-TNF-α mAbs to abrogate cAMP analogue-induced DP apoptosis in a dose-dependent manner; and 2) increased resistance of DP thymocytes from TNF-α−/− and TNFR I−/−II−/− animals to cAMP agonist-mediated apoptosis. cAMP agonists induced DP thymocyte death by a combination of two mechanisms: first, they induced selective up-regulation of TNF-α production, and, second, they sensitized DP thymocytes to TNF-α. The latter effect may be due to the down-regulation of TNFR-associated factor 2 protein. These results identify TNF-α as the critical mediator of cAMP-induced apoptosis in thymocytes and provide a molecular explanation for how the cAMP stimulators, including the sex steroids, may modulate T cell production output, as observed under physiological and pharmacological conditions.
Radiative Symmetry Breaking from Flat Potential in various U(1)' models
Creators: name: Hashimoto, Michio
name: Iso, Satoshi
name: Orikasa, Yuta
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We investigate a radiative electroweak gauge symmetry breaking scenario via the Coleman-Weinberg mechanism starting from a completely flat Higgs potential at the Planck scale ("flatland scenario"). In our previous paper, we showed that the flatland scenario is possible only when an inequality K<1 among the coefficients of the beta functions is satisfied. In this paper, we calculate the number K in various models with an extra U(1) gauge sector in addition to the SM particles. We also show the renormalization group (RG) behaviors of a couple of the models as examples.
description: 14 pages, 5 figures; references added, to appear in PRD
Additional file 3 of Mapping and understanding the decision-making process for providing nutrition and hydration to people living with dementia: a systematic review
Creators: name: Anantapong, Kanthee
name: Davies, Nathan
name: Chan, Justin
name: McInnerney, Daisy
name: Sampson, Elizabeth L.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 3:. Full search strategy MEDLINE.docx
Melancholy and the loss of self: a nomadic inquiry
Creators: name: Vermeulen, Tim
Publisher: name: The University of Edinburgh
Year: 2023
Subjects: melancholy
loss of self
nomadism
melancholic ethic
melancholia
Freud
Klein
Lacan

description: I’m sitting across from my client, S, wishing I could escape the crushing gravity of the black sun (Kristeva 1989). Its dark rays render our bodies inert, and each utterance becomes too frail to carry meaning. Yet, every so often, in our melancholic stupor, we are seduced by the radiance of a desperate and beautiful sadness that returns us to loss, and the impossibility of mourning. Through wandering and wondering (Tamas 2010) I find myself on nightly walks or wading through memories of my mother’s death. I attempt to step into the contradictions where deadness meets desire. I wish I could untether and dissolve into nothingness. Here I find a melancholic fantasy which I call ‘the loss of self’. Ever the diligent practitioner, I turn to Freud, Kristeva, and Lacan for some support. Their different voices offer me layered perspectives on melancholia, from hallucinating the lost loved object (Freud 1917), to elaborately mourning the loss of something that is available, but no longer desired (Žižek 2000). Yet something of their thinking constrains me, their ideas too focused on a specific relationality to the lost object.
Mid- to far infrared properties of star-forming galaxies and active galactic nuclei
Creators: name: Magdis, G. E.
name: Rigopoulou, D.
name: Helou, G.
name: Farrah, D.
name: Hurley, P.
name: Alonso-Herrero, A.
name: Bock, J.
name: Burgarella, D.
name: Chapman, S.
name: Charmandaris, V.
name: Cooray, A.
name: Dai, Y. S.
name: Dale, D.
name: Elbaz, D.
name: Feltre, A.
name: Hatziminaoglou, E.
name: Huang, J-S
name: Morrison, G.
name: Oliver, S.
name: Page, M.
name: Scott, D.
name: Shi, Y.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We study the mid- to far-IR properties of a 24um-selected flux-limited sample (S24 > 5mJy) of 154 intermediate redshift (~0.15), infrared luminous galaxies, drawn from the 5MUSES survey. By combining existing mid-IR spectroscopy and new Herschel SPIRE submm photometry from the HerMES program, we derived robust total infrared luminosity (LIR) and dust mass (Md) estimates and infered the relative contribution of the AGN to the infrared energy budget of the sources. We found that the total infrared emission of galaxies with weak 6.2um PAH emission (EW<0.2um) is dominated by AGN activity, while for galaxies with EW>0.2um more than 50% of the LIR arises from star formation. We also found that for galaxies detected in the 250-500um Herschel bands an AGN has a statistically insignificant effect on the temperature of the cold dust and the far-IR colours of the host galaxy, which are primarily shaped by star formation activity. For star-forming galaxies we reveal an anti-correlation between the LIR-to-rest-frame 8um luminosity ratio, IR8 = LIR\L8, and the strength of PAH features. We found that this anti-correlation is primarily driven by variations in the PAHs emission, and not by variations in the 5-15um mid-IR continuum emission. Using the [NeIII]/[NeII] line ratio as a tracer of the hardness of the radiation field, we confirm that galaxies with harder radiation fields tend to exhibit weaker PAH features, and found that they have higher IR8 values and higher dust-mass-weighted luminosities (LIR/Md), the latter being a proxy for the dust temperature (Td). We argue that these trends originate either from variations in the environment of the star-forming regions or are caused by variations in the age of the starburst. Finally, we provide scaling relations that will allow estimating LIR, based on single-band observations with the mid-infrared instrument, on board the upcoming JWST.
description: Accepted for publication in A&A