cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Exploring the perspectives of community members as research partners in rural and remote areas
Creators: name: Pelletier, Chelsea A
name: Pousette, Anne
name: Ward, Kirsten
name: Fox, Gloria
Publisher: name: BioMed Central
Year: 2020

description: Background: Community engagement in research has the potential to support the development of meaningful health promotion interventions to address health inequities. People living in rural and remote areas face increased barriers to participation in health research and may be unjustly excluded from participation. It is necessary to understand the process of patient and public engagement from the perspective of community members to support partnered research in underserved areas. The aim of this project was to increase understanding on how to include community members from rural and remote areas as partners on research teams. Methods: Using purposive sampling, we completed semi-structured interviews with a representative sample of 12 community members in rural and remote areas of northern British Columbia, Canada. Interviews were audio recorded and transcribed verbatim. Following an integrated knowledge translation approach, an inductive thematic analysis was completed to incorporate researcher and knowledge user perspectives. Results: The factors important to community members for becoming involved in research include: 1) relevance; 2) communication; and 3) empowering participation. The analysis suggests projects must be relevant to both communities and individuals. Most participants stated that they would not be interested in becoming partners on research projects that did not have a direct benefit or value for their communities. Participants expressed the need for clear expectations and clarification of preferred communication mechanisms. Communication must be regular, appropriate in length and content, and written in a language that is accessible. It is essential to ensure that community members are recognized as subject matter experts, to provide appropriate training on the research process, and to use research outcomes to support decision making. Conclusions: To engage research partners in rural and remote communities, research questions and outcomes should be co-produced with community members. In-person relationships can help establish trust and bidirectional communication mechanisms are prudent throughout the research process, including the appropriate sharing of research findings. Although this project did not include community members as research team members or in the co-production of this research article, we present guidelines for research teams interested in adding a patient or public perspective to their integrated knowledge translation teams.
Les laïcs dans l’histoire de la philosophie médiévale
Creators: name: König-Pralong, Catherine
Publisher: name: Doctor Virtualis
Year: 2010

description: Con particolare riferimento alla ricerca degli ultimi sessant'anni, l'articolo si propone di suggerire alcune riflessioni metodologiche. Nella recente storiografia filosofica si possono individuare due movimenti di particolare rilievo: in primo luogo, il recupero di grandi figure come Lullo, Petrarca e Dante nel campo della filosofia e, in secondo luogo, l'attenzione per autori poco studiati che si muovono in spazi talvolta trascurati, l'interesse per i quali nasce spesso dall'incontro della storia della filosofia con la storia sociale e culturale.   Particularly concerning to researches of the last sixty years, the article aims to suggest some interesting methodological reflections. In the recent philosophical historiography we can identify two movements of singular importance: in the first place, the retrieval of great figures, as Lullo, Petrarca and Dante, in the field of philosophy and, secondly, the attention for barely studied authors who live in sometimes neglected environments, the new interest for which often stems from encounter of the history of philosophy with the social and cultural history.
description: Doctor Virtualis, N° 9 (2009): Laicità e Medioevo
Dynamic Alpha Congestion Controller for WebRTC
Creators: name: Atwah, Rasha Jamal M.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Google Congestion Control
Real Time Communication
Congestion Control

description: Video conferencing applications have significantly changed the way in which people communicate over the Internet. Web real-time communication (WebRTC), drafted by the World Wide Web Consortium (W3C) and the Internet Engineering Task Force (IETF), has added new functionality to web browsers, allowing audio/video calls between browsers without the need to install any video telephony applications. The Google Congestion Control (GCC) algorithm has been proposed as WebRTC’s receiver congestion control mechanism, but its performance is limited due to using a fixed incoming rate decrease factor, known as an alpha (α). In this thesis, we have proposed a dynamic alpha model to reduce the receiving bandwidth estimate during overuse, as indicated by the overuse detector. Experiments using our specific testbed show that our proposed model achieves a higher incoming rate and a lower Round-Trip Time while slightly increasing the packet loss rate in some cases compared to fixed alpha model. Our mathematical model proves that it is necessary to use an adaptive alpha α as the receiver side controller. The experimental results show improvement in the term of incoming rate, Round-Trip Time, and packet fraction loss rate in some cases. Our model increases the amount of incoming rate and decreases Round-Trip Time and fraction loss.
Per una lettura laica della teologia medievale
Creators: name: Buzzetti, Dino
Publisher: name: Doctor Virtualis
Year: 2010

description: È possibile operare una forma di epoché sui concetti di carattere teologico? Ed è possibile riflettere sulla loro importanza, prescindendo dalla loro portata religiosa? I concetti teologici riescono a dirci qualcosa, se si trascura il loro riferimento essenziale alla nostra relazione con un essere divino? La risposta a queste domande consente di comprendere che cosa significhi essere un studioso laico della filosofia medievale, mentre è impossibile discutere tale problema senza prendere in considerazione anche la teologia medievale. Tutto ciò dunque riguarda non solo la natura della teologia, ma anche l’idea stessa di laicità. Dunque una storiografia del pensiero medievale pienamente consapevole di se stessa deve studiare il discorso teologico e affrontare in profondità la portata teorica di questo problema. Si può concludere che per una lettura laica della teologia medievale è paradossalmente essenziale cogliere proprio il senso intimo del pensiero religioso e le forme storicamente determinate della sua effettiva concettualizzazione.   Is some form of epoché possible on theological concepts? In which way? Is it possible consider their importance leaving their religious scope aside? Can the theological concepts tell us something unless we consider their essential reference to our relationship with a divine being? The answer to these questions let us to understand what means to be a secular (laico) scholar of medieval philosophy. It's impossible conversely to discuss this problem without dealing with medieval theology. And this concerns not only the nature of theology, but also and deeply the same idea of secularism (laicità). Therefore a fully aware historiography of medieval thought has to understand the theological speech and to encounter the depth of this theoretical question. So we can conclude that for a secular reading of the medieval theology is paradoxically essential to catch the intimate sense of religious thought and the historically defined forms of its actual conceptualizations.
description: Doctor Virtualis, N° 9 (2009): Laicità e Medioevo
Synthesis and Preliminary Evaluation of an F-18 Labeled Fluoropyridine Losartan Analog as a Novel PET Tracer for Imaging AT1 Receptors
Creators: name: Arksey, Natasha C.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: AT1R
F-18
AngII
PET

description: Several cardiac diseases, including hypertrophy, cardiomyopathy, and myocardial infarction, result in the upregulation of cardiac angiotensin II type-1 receptors (AT1R). Imaging the AT1R in vivo via PET provides the potential to monitor disease progression and guide therapy accordingly. The aim of this research was to develop a novel F-18 labeled losartan analog as an AT1R PET tracer and begin evaluation in rats. Due to the longer half-life and shorter positron range of F-18, we presume that an F-18 labeled tracer will be more beneficial than current C-11 labeled tracers. Prior structure-activity relationship (SAR) studies suggested the addition of substituents to the hydroxyl group of losartan would minimally affect AT1R binding affinity. [18F]Fluoropyridine losartan ([18F]FPyrLos) was synthesized in an automated module through conjugation of [18F]fluoro-3-pent-4-yn-1-yloxypyridine ([18F]FPyKYNE) to azide-modified losartan via the Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC) ‘click’ reaction. [18F]FPyrLos was produced in approximately 10% yield (decay-corrected) with > 97.5% purity and specific activities up to 4,200 mCi/µmol. MicroPET (Siemens Inveon) images of normal Sprague Dawley rats displayed high uptake in the kidneys (ratio of 8.3 compared to surrounding tissue at 10 min). Metabolite analysis in the kidneys and plasma by column-switch HPLC revealed that roughly two-thirds of the tracer was unchanged 10 min post-injection and that one labeled hydrophilic metabolite exists, accounting for roughly 6% of the total activity. Both microPET and metabolism studies displayed a dose-dependent reduction in renal uptake upon co-injection with AT1R blocker candesartan indicating specific binding. Further work in rat disease models is required to evaluate the potential of this tracer for imaging cardiac AT1R.
Dialogo tra un mistico,  uno scettico e un retore
Creators: name: Parodi, Massimo
Publisher: name: Doctor Virtualis
Year: 2010

description: Una specie di favola, ispirata al Dialogus di Abelardo, per riflettere sul ruolo del cristianesimo nello sviluppo del pensiero filsofico medievale. La filosofia medievale è complessa e articolata come quella di ogni altro periodo storico e spesso, anziché porsi al servizio della teologia, si appoggia sui contenuti della fede per dare stabilità alle proprie ricerche.   A sort of tale, inspired by the Abaelard's Dialogus, to consider the role of christianity in the development of the medieval philosophical thought. The medieval philosophy is complex and articulated as that of any other historical period and often, instead of being at the service of theology, is founded on the contents of faith to give stability to its own research.
description: Doctor Virtualis, N° 9 (2009): Laicità e Medioevo
Abandon des cours d'éducation physique : parole aux étudiantes francophones.
Creators: name: Brun, Chantale R.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Women's Studies.

description: Le but principal de cette étude était d'investiguer les facteurs qui ont motivé les jeunes femmes francophones du secondaire à abandonner leurs cours d'éducation physique et les facteurs qui les motiveraient à réintégrer ces cours. L'entrevue de groupe a été privilégiée comme instrument permettant de recueillir ces facteurs d'abandon et de réintégration. Onze entrevues de groupe ont donc été réalisées, impliquant 38 étudiantes de deux écoles secondaires francophones du sud-est du Nouveau-Brunswick. Les résultats de l'étude ont été regroupés sous cinq thèmes principaux: (a) les perceptions envers l'éducation physique et l'activité physique, (b) les sentiments à l'égard des cours d'éducation physique et à l'égard de l'activité physique, (c) les facteurs d'abandon des cours, (d) les éléments associés à un cours idéal et (e) les facteurs de réintégration à un cours d'éducation physique. Les principaux facteurs d'abandon de l'éducation physique sont reliés au manque d'importance de l'éducation physique, au contenu insatisfaisant des cours, au manque de considération pour certaines questions corporelles, à l'attitude négative du personnel enseignant, aux attitudes méprisantes des garçons et aux méthodes d'évaluation inadéquates. Les résultats de l'étude indiquent également que les facteurs qui motiveraient les jeunes femmes à réintégrer un cours d'éducation physique sont le contenu plus varié des cours, l'attitude positive du personnel enseignant, l'importance accordée à l'éducation physique, la considération des questions corporelles, les méthodes d'évaluation équitables et l'attitude respectueuse des confrères et consoeurs de classe.
The experience of technological change in rural Australia: comparing emancipatory rhetoric with empirical reality
Creators: name: Kwansah-Aidoo, Kwamena
name: Elson, Shane G.
Publisher: name: Swinburne
Year: 2024

description: This paper is an attempt to compare the heralded potentials of new Information and Communication Technologies with the real life situation of people who have adopted them. Specifically, it discusses the uptake and utilisation of ICTs in three localities in the rural Gippsland Region of Victoria, Australia. It addresses the question of whether the promised emancipatory potentials of ICTs have been realised in the lives of people who have adopted them in that setting. Using Habermas' constructs of 'emancipatory potentials' and 'communicative action' we develop a theoretical model to test the proposition that ICTs have emancipatory potentials as suggested by the dominant discourses. The model encompasses the four themes of participation, integration, ability of ICTs to overcome context and responses or resistance to change. We conclude that the de-contextualised nature of ICT mediated communications do offer limited forms of emancipation. In addition to that, we contend that while the Habermasian notions of communicative action and emancipatory potentials are ideals, they are no less legitimate than the idealisms expressed in the dominant discourses.
Un'eco d'Oriente. Sekherezada di Rimskij-Korsakov
Creators: name: Riccardi, Letizia
Publisher: name: Doctor Virtualis
Year: 2010

description: Oggi come in passato l'Oriente è vittima di stereotipi derivati dalla tradizione orientalistica ottocentesca che ha contribuito a plasmare una miriade di cliché esotici dai quali fatichiamo a renderci indipendenti. In questo intervento si cerca di segnalare, e in parte demitizzare, alcuni di tali luoghi comuni, con particolare riferimento al contesto musicale russo di fine Ottocento. Nel quadro dell'immaginario dell'Oriente che si sviluppa nella cultura russa si colloca la suite sinfonica Sekherezada op. 35 di Nikolaj Andreevič Rimskij-Korsakov: temi popolari di sapore orientaleggiante si sviluppano su impianti sonori di grande effetto che trasportano gli uditori in un mondo lontano, sconosciuto, immaginato, chiamato Oriente As a consequence of the multitude of exotic cliché shaped by the eighteenth-century orientalistic tradition, the East has always fallen victim to a series of misleading stereotypes from which we can hardly set free.The aim of this paper is to bring to light and demythologize some of those cliché, with particular attention paid to the eighteenth-century musical output in Russia. Among the Russian musical works that focus on the theme of the East is the symphonic suite Sekherezada op. 35 composed by Nikolaj Andreevič Rimskij-Korsakov: oriental-sounding folk themes develop on impressive sonorities taking the listener to a far-away, unknown, imaginary place, called “East”.
description: Doctor Virtualis, N° 9 (2009): Laicità e Medioevo
title: Checklisten für die Untersuchung und Beurteilung des Zustandes von Anlagen mit wassergefährdenden Stoffen und Zubereitungen in der Zellulose- und Papierindustrie
title: Zellulose- und Papierindustrie: Checkliste Nr. ZT. 0: BVT
titleType: AlternativeTitle
Creators: name: Winkelmann-Oei, Gerhard
Publisher: name: My University
Year: 2016
Subjects: subject: Papierindustrie
subject: Zellstoffindustrie
subject: Gewässerschutz
subject: Wasserverunreinigung
subject: Risikomanagement
subject: Leitfaden
subject: Zelluloseindustrie
subject: Zellstoffproduktion
subject: Wasserverschmutzung
subject: Wasserschadstoffe
subject: Checkliste
subject: Chemikalien
subject: Chemicals

description: Diese branchenspezifischen Checklisten bilden einen Leitfaden für die Untersuchung und Beurteilung des Zustandes von Anlagen mit wassergefährdenden Stoffen und Zubereitungen in der Zellulose- und Papierindustrie. Dabei bieten sie eine Übersicht über die verschiedenen Handlungsfelder sowie einen nach Produktionsbereichen aufgeteilten Bereich um potentielle Risikoquellen und Modernisierungsziele zu identifizieren. Quelle: Bericht
description: Diese branchenspezifischen Checklisten bilden einen Leitfaden für die Untersuchung und Beurteilung des Zustandes von Anlagen mit wassergefährdenden Stoffen und Zubereitungen in der Zellulose- und Papierindustrie. Dabei bieten sie eine Übersicht über die verschiedenen Handlungsfelder sowie einen nach Produktionsbereichen aufgeteilten Bereich um potentielle Risikoquellen und Modernisierungsziele zu identifizieren.
Documenting Reproducibility: The Integral Role of Documentation in Transparent Qualitative Research
Creators: name: Haaker, Maureen
Publisher: name: Zenodo
Year: 2024

description: An international drive for open data has been growing since the early 2000s to promote greater reproducibility within research. This has culminated in Wilkinson’s et al (2016) guidelines for FAIR data. As these calls for reproducibility and FAIR data are codified in data policies and publishing ethics, it raises difficult questions for qualitative researchers for how transparency can be consistently and ethically demonstrated within their projects. Using observations and findings from a systematic review of over 1000 qualitative collections held at the UK Data Service, this presentation presents an archive’s point-of-view of how innovative ways of documenting data and new curation tools can provide support for demonstrating process and analytic transparency in qualitative research. I outline key ways that good practices in data management and curation support transparency, as well enhanced ways that go further in showing research integrity. As part of this discussion, I introduce exemplary case studies from the UK Data Service’s collections and qualitative-specific tools developed at the UK Data Service which exemplify the core principles of transparency and reproducibility in qualitative research. Reflecting on the recent developments in curation, this presentation offers qualitative researchers new possibilities for constructively responding to calls for reproducibility, as well as providing further guidance on how policies and procedures might take into account the specific needs of qualitative data.
Investigating the Experiences of Track Athletes during a Season-long Psychological Skills and Biofeedback Training Program
Creators: name: Stelfox, Kara B
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: psychological skills training
biofeedback
focus
arousal control
debriefing
track athletes
qualitative research

description: The purpose of this study was to explore the experiences of five track athletes (three men and two women, aged 18-33 yrs) during a season-long PST-Biofeedback training program designed to help them learn how to self-regulate physiologically, psychologically, and emotionally. Three key psychological skills were emphasized: focus (Janelle, 2002; Nideffer & Sagal, 2006), arousal control through biofeedback training (e.g., Bar-Eli, Dreshman, Blumenstein, & Weinstein, 2002), and debriefing (Hogg, 2002; McArdle, Martin, Lennon, & Moore, 2010). The program, which consisted of one-on-one initial and final semi-structured interviews with PST-biofeedback sessions in between, was individualized to meet each athlete’s needs and progress during the study. Results indicated that the athletes found the program helpful; they perceived an improvement in their ability to focus, debrief, and control arousal in the lab; and, to varying degrees, they transferred those skills into training and competition. The athletes also perceived an improvement in their sport performances.
Thermal spray: the best thing since sliced bread?
Creators: name: Berndt, Christopher
Publisher: name: Swinburne
Year: 2024

description: This article discusses thermal spray technology. Thermal spray's microstructure sometimes provokes skepticism about the suitability of thermal spray to a particular application. Questions about such issues as surface roughness and tensile strength are apt to arise. As a practical matter, though, thermal spray has a good track record.
Evaluation and facilitation of intervention fidelity in community exercise programs through an adaptation of the TIDier framework
Creators: name: Bird, Marie-Louise
name: Mortenson, W. Ben
name: Eng, Janice
Publisher: name: BioMed Central
Year: 2020

description: Background: Despite high quality evidence supporting multiple physical and cognitive benefits of community-based exercise for people after stroke, there is little understanding on how to facilitate uptake of these research findings to real-world programs. A common barrier is a lack of standardised training for community fitness instructors, which hampers the ability to train more instructors to deliver the program as it was designed. Scaling up program delivery, while maintaining program fidelity, is complex. The objective of this research is to explore novel use of the Template for Intervention Description and Replication (TIDier) framework to evaluate and support implementation fidelity of a community exercise program. Methods: We embedded intervention fidelity evaluation into an inaugural training program for fitness instructors who were to deliver the Fitness and Mobility Exercise Program for stroke, which has established efficacy. The training program consisted of a face-to-face workshop followed by 3 worksite ‘audit and feedback coaching cycles’ provided over 3 iterations of the 12-week program offered over 1 year. A modified TIDIER checklist (with 2 additional criteria) was used within the training workshop to clarify the key ‘active ingredients’ that were required for program fidelity, and secondly as a basis for the audit and feedback process enabling the quantitative measurement of fidelity. Data were collected from audits of observed classes and from a survey provided by fitness instructors who implemented the program. Results: We demonstrated the feasibility of the TIDier checklist to capture 14 essential items for implementation evaluation of a complex exercise intervention for people with chronic health conditions over 3 iterations of the program. Based on the audit tool, program fidelity was high and improved over time. Three content areas for workplace coaching (intensity monitoring, space, and educational tips) were identified from the audit tool and were addressed. Conclusion: Training of staff to deliver exercises to high need populations utilising workshops and workplace coaching that used the TIDier framework for training, onsite audit and feedback resulted in a high level of fidelity to the program principles. A novel checklist based on the TIDier framework was useful for embedding implementation fidelity in complex community-based interventions.
title: Bisphenol A and six other environmental phenols in urine of children and adolescents in Germany - human biomonitoring results of the German Environmental Survey 2014-2017 (GerES V)
title: Bisphenol A and six other environmental phenols in urine of children and adolescents in Germany - human biomonitoring results of the German Environmental Survey 2014-2017 (GerES V)
titleType: AlternativeTitle
Creators: name: Kolossa-Gehring, Marike
name: Tschersich, Carolin
name: Murawski, Aline
name: Rucic, Enrico
name: Schwedler, Gerda
Publisher: name: My University
Year: 2021
Subjects: Triclosan
Endokrin wirksame Substanz
Risikoanalyse

description: Exposure to environmental phenols such as bisphenol A, benzophenones, 2-phenylphenol, triclosan, and triclocarban is of concern, because of their endocrine disrupting properties and broad application in consumer products. The current body burden of the 3-17-year-old population in Germany to these substances was assessed in first-morning void urine samples (N = 515-516) collected within the population-representative German Environmental Survey for Children and Adolescents 2014-2017 (GerES V). Bisphenol A was the most prominent phenol analysed here, ubiquitously found in almost all samples with a geometric mean (GM) concentration of 1.905 (my)g/L (1.669 (my)g/gcreatinine) and a maximum (MAX) urinary concentration of 399 (my)g/L. Benzophenone-3 and benzophenone-1 were quantified in 35% and 41% of the samples. GM was below the limit of quantification (LOQ) for benzophenone-3 and 0.559 (my)g/L (0.489 (my)g/gcrea) for benzophenone-1, MAX concentrations were 845 (my)g/L and 202 (my)g/L, respectively. In 16% of the samples triclosan was found in quantifiable amounts resulting in a GM below LOQ and a MAX concentration of 801 (my)g/L. Benzophenone-8, 2-phenylphenol and triclocarban were quantified in none or only 1% of the samples. Benzophenone-1 and -3 concentrations were found to be associated with frequent application of personal care products. A comparison with the previous cycle of the survey, GerES IV (2003-2006), showed a decrease of urinary bisphenol A concentrations, mainly in young children. Despite this decrease, the concentration of bisphenol A exceeded the human biomonitoring (HBM) value HBM-I of 0.1 mg/L in 0.11% of the samples. For triclosan, all urinary concentrations were well below the HBM-I value of 2 mg/L. To minimise environmental health risks, it is therefore necessary to maintain a further declining trend for bisphenol A and continue monitoring the exposure to environmental phenols, as well as to monitor substitutes such as bisphenol F and S. © 2020 Published by Elsevier B.V.
Graduate attributes: what are they and how do we know if students can achieve them?
Creators: name: Levin, Elizabeth
name: Tempone, Irene
name: Salehi, Kay
Publisher: name: Swinburne
Year: 2024

description: This paper considers two practical issues regarding graduate attributes. The first issue concerns the development of a comprehensive list of graduate attributes whilst the second issue addresses the question of how one determines whether graduate attributes and generic skills have been adequately fostered throughout an undergraduate program of study.
Hārūn al-Rashīd e al-Muqtadir. Come distinguere un buon califfo da un cattivo califfo
Creators: name: Osti, Letizia
Publisher: name: Doctor Virtualis
Year: 2010

description: In questo articolo ci si occupa di come il regno e la vita di due califfi abbasidi siano ritratti e valutati dalle fonti narrative arabe medievali. Hārūn al-Rashīd (r. 170/786-193/809) e al-Muqtadir (r. 295/908-320/932) divennero, pochi decenni dopo la loro morte, il paradigma del buono e del cattivo califfo rispettivamente; tuttavia, i loro lunghi califfatia le loro biografie personali presentano diversi elementi comuni. Un'analisi  di temi simili presenti nelle rappresentazioni dei due sovrani illustrano mezzi e strategie narrativi impiegati dalle fonti, nel tentativo di stabilire quali fattori determinino lo sviluppo di una reputazione post-mortem positiva o negativa.This paper looks at how the lives and reigns of two Abbasid caliphs are portrayed and evaluated in medieval Arabic narrative sources. Hārūn al-Rashīd (r. 170/786-193/809) and al-Muqtadir (r. 295/908-320/932) became, only a few decades after their death, the paradigm of the good and the bad caliph respectively. However, their long caliphates as well as their personal biographies share several elements. An analysis of similar themes in the portrayals of the two rulers illustrates narrative means and strategies employed by the sources, in an attempt to establish which factors determine the development of a positive or negative post-mortem reputation.
description: Doctor Virtualis, N° 9 (2009): Laicità e Medioevo
Candidate Genes In the Gut and Pancreas of Diabetes-prone Rats
Creators: name: Noel, Janet Ariana
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Type 1 Diabetes
Gene Expression
Beta-cell
Diet
Pancreas
Jejunum

description: Type 1 diabetes (T1D) is an autoimmune disorder, targeting the β-cells of the pancreas. Processes occurring in the gut and pancreas are inferred to be involved. The pre-diabetic expression signature in these tissues is largely uncharacterized. HYPOTHESIS: Spontaneous models of T1D, the LEW.1AR1/Ztm-iddm rat (LEW-DP) and BioBreeding diabetes-prone rat (BBdp) exhibit a distinct transcriptional signature prior to T1D onset. Transcriptional profiling was used to elucidate the expression signatures of the LEW-DP gut and BBdp pancreas. The LEW-DP gut displayed decreased expression of markers of anti-inflammatory M2 macrophages. The LEW-DP rats showed an upregulation of markers of pro-inflammatory signaling when fed a diabetes-promoting cereal diet compared with LEW-DP rats fed a protective hydrolyzed casein diet. Prospective pancreatectomy was used to analyze T1D development in the BBdp rat. Significant upregulation of β-cell markers Reg3α, Reg3β, and Trim26 was observed in pre-diabetic rats. Thus, it was shown that environment modifies the transcriptional program and the transcriptional profile is programmed early to affect T1D development.
Funerary inscription for Xenokritos son of Hephaistokles, of Massalia
Creators: name: Prag, Jonathan
Publisher: name: Zenodo
Year: 2018
Subjects: subject: Sicily
subject: epigraphy
subject: http://vocab.getty.edu/page/aat/300138808
subject: https://pleiades.stoa.org/places/462492

description: TEI EpiDoc record
Sensorsysteme zur Messung der Luftqualität
Creators: name: Brauer, Hannes
name: Bastian, Susanne
name: Conrad, Thorsten
name: Travnicek, Wilma
name: Wirtz, Klaus
Publisher: name: VDI-Verlag
Year: 2021
Subjects: Luftreinhaltung

description: Auf dem Markt sind heutzutage sehr einfach aufgebaute und daher zum Teil vergleichsweise preisgünstige Sensorsysteme verfügbar. In der Öffentlichkeit stoßen diese Sensorsysteme zur Messung der Luftqualität auf großes Interesse. Sie werden häufig abseits der behördlichen Messstationen in der Fläche eingesetzt, um dort ortsbezogen die Luftqualität zu ermitteln. Zum Vergleich der Ergebnisse werden sie mitunter auch direkt neben diesen Messstationen betrieben. Aber sie erfüllen die gesetzlichen Anforderungen an die Güte von Luftqualitätsmessungen für sich nicht und können derzeit nicht zur gesetzlichen Überwachung von Grenzwerten der Luftqualität eingesetzt werden. Sie sind aktuell keine Alternative zu den in den Messnetzen der Bundesländer eingesetzten Referenzmessverfahren, können allerdings in bestimmten Situationen eine sinnvolle Ergänzung darstellen. Die Nutzung von geeigneten Sensorsystemen in Kombination mit Ausbreitungsmodellen kann das Vertrauen in vorhandene Ausbreitungsmodellierungen stärken. Maßnahmen zur Produktzertifizierung seitens der Hersteller und regelmäßige unabhängige Prüfungen auf Basis technischer Standards können wesentlich dazu beitragen, die Nutzung von Sensorsystemen zu fördern und das Vertrauen in die Verlässlichkeit der damit gewonnenen Messwerte zu erhöhen. Quelle: https://www.vdi.de/
Content and Method of Information for Participants in Clinical Studies With Induced Pluripotent Stem Cells (iPSCs)
Creators: name: Orzechowski, Marcin
name: Schochow, Maximilian
name: Kühl, Michael
name: Steger, Florian
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Clinical translation
subject: Clinical research
subject: DDC 610 / Medicine & health
subject: Induced pluripotent stem cells
subject: Research
subject: Informed consent
subject: Ethics, Clinical
subject: Induzierte pluripotente Stammzelle

description: Research with induced pluripotent stem cells (iPSCs) involves specific ethical challenges, which should be addressed in the informed consent process. Up to now, little concern has been paid to the practice of information in iPSC-clinical studies. In order to fill this research gap, we have searched the documentation of the Research Ethics Committee at Ulm University from the years 2007 to 2019. In our previous research, we have identified 11 items for evaluation of the process of information in iPSC research. We used these items to analyze content and form of information provided for participants in the iPSC studies conducted at Ulm University and Ulm University Hospital in Germany. All analyzed studies provide general information regarding the study’s aim, method, and collection of donor’s personal data and specimen. The information for participants in these studies adheres to general guidelines for research involving human subjects; however, in several areas fails to take into account the specific nature of research with iPSCs. The majority of analyzed studies fail to provide information about possible individual consequences connected with genetic research, such as the possibility of re-identification of the donor or incidental findings acquired during research. Missing is also information about the possibility of future studies involving reproductive research or transplantation of cells and organs. The donor information process in all analyzed studies is conducted in form of the information sheet and oral information. The results of our research show that the process of informed consent in iPSC research should be updated as new developments emerge in this area. However, comprehension of information should not be jeopardized through information overload. Effective communication of essential information requires improved information methods tailored to the needs of participants, such as video animations, interactive consent modules or social media instruments.
Multidimensional Nonlinear Femtosecond Spectroscopy of Biological Molecules
Creators: name: Lincoln, Craig
Publisher: name: Swinburne
Year: 2024

description: In this thesis photon echo spectroscopy is extended by measuring the spec- trum of the scattered signal (spectrally resolved photon echo) and by using two different wavelengths for the different applied laser pulses (two-colour photon echo), in order to investigate the ultrafast dynamics in biological molecules. To characterise the signal response of the spectrally resolved measurement a theoretical study using the Multimode Brownian Oscillator (MBO) model is performed. The MBO model describes the interaction of the analyte of interest and the surrounding environment in terms of a time- dependent correlation function M(t). The inverse linewidth of the measured signal spectra is found to correspond well with the temporal width of the photon echo pulse and an analytical fit to the signal is able to reasonably describe both the coupling strength and the dynamics of the time-dependent correlation function. The spectrally resolved and two-colour measurement techniques are ap- plied to a laser dye, rhodamine 101, to characterise the signal response (photophysics) of a molecule that does not undergo a chemical reaction. The measurement of the nonlinear signal spectra for rhodamine 101 proved in- valuable in identifying the different underlying photophysical processes that would otherwise have been difficult given only integrated intensity data. Another interesting result of measuring the signal spectra is the ability to characterise separately the ground and excited state dynamics. Information about the dynamics of fast processes that are otherwise difficult to deter- mine can be extracted using the two-colour technique. The combination of the spectrally resolved and two-colour techniques showed that AC-Stark effects are present and need to be considered when performing photon echo (transient grating) experiments. The new technique, two-colour spectrally resolved photon echo spec- troscopy, is applied to the biological system carbonmonoxy myoglobin (MbCO). Upon illumination MbCO undergoes a reaction where the carbonyl complex dissociates to form deoxy-myoglobin (deoxy-Mb). This study provides sup- porting evidence for the mechanism and the dynamics of the initial steps involved in this photodissociation reaction. We show that a change in spin state from the low spin bound state to the high spin unbound state occurs in the first 200 fs after excitation: the photophysics of photodissociation involve a second (intermediate) excited state with a lifetime of around 200 fs for MbCO and not vibrational cooling of a hot ground state as proposed in a previous model. Other photophysical time scales are also estimated: the Fe-CO bond breakage occurs within 25 fs and the lifetime of the Q-band levels is 35 fs.
Supplementary document for Magnetically driven rotary microfilter fabricated by two-photon polymerization for multimode filtering of particles - 5210465.pdf
Creators: name: Wu, Dong
name: Wang, Chaowei
name: Hu, Zhijiang
name: Yang, Liang
name: Zhang, Chenchu
name: Zhang, Leran
name: Ji, Shengyun
name: Xu, Liqun
name: Li, Jiawen
name: Hu, Yanlei
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized
Nonlinear Optics and Spectroscopy

description: Supplemental document
Identification of Mechanisms Regulating Endothelial Cell Capillary Morphogenesis
Creators: name: Howe, Grant Alexander
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: RhoB
RhoA
miRNA
miR-30b
TGF beta
VEGF
capillary morphogenesis
angiogenesis
endothelial

description: In order to effectively treat disorders whose pathology is marked by neovascularization, a better understanding of the pathways that mediate the processes involved in angiogenesis is needed. To this end we have identified two important pathways that regulate endothelial cell capillary morphogenesis, a key process in angiogenesis. We have identified the small GTPase RhoB as being induced by vascular endothelial growth factor (VEGF) in human umbilical vein endothelial cells (HUVECs). Depletion of RhoB inhibited endothelial cell VEGF - mediated migration, sprouting, and cord formation. Cells depleted of RhoB showed a marked increase in RhoA activation in response to VEGF. Defects in cord formation in RhoB - depleted cells could be partially restored through treatment with the Rho inhibitor C3 transferase or ROCK I/II inhibitors, indicating increased RhoA activity and enhanced downstream signaling from RhoA contribute to the phenotype of decreased cord formation observed in cells depleted of RhoB. Interestingly, we did not observe a significant change in RhoC activity in RhoB - depleted cells suggesting differential regulation of RhoA and RhoC by RhoB in HUVECs. We have also identified microRNA - 30b (miR - 30b) as being negatively regulated by VEGF and as being a negative regulator of HUVEC capillary morphogenesis. Overexpression of miR - 30b significantly reduced HUVEC cord formation in vitro, while inhibition of miR - 30b enhanced cord formation. Neither overexpression nor inhibition of miR - 30b affected migration or viability of endothelial cells. Interestingly, miR - 30b regulated the expression of TGFβ2 but not TGFβ1, with overexpression of miR - 30b inducing expression of TGFβ2 mRNA and protein, and inducing phosphorylaton of Smad2 , suggesting TGFβ2 produced in response to miR - 30b overexpression functions in an iii autocrine manner to stimulate HUVECs . MiR - 30b effects on TGFβ2 expression were found to be regulated to an extent by ATF2, as miR - 30b overexpressing cells exhibited increased levels of phosphorylated ATF2 , with depletion of ATF2 via siRNA resulting in inhibition of miR - 30b - induced TGFβ2 expression. Treatment of HUVECs with TGFβ2 inhibited cord formation, while TGFβ1 had no effect, indicating a major difference in how endothelial cells respond to these two related growth factors. Inhibition of TGFβ2 with a neutralizing antibody restored cord formation in miR - 30b overexpressing cells to levels similar to control cells, thus identifying TGFβ2 expression as contributing to the inhibitory effects of miR - 30b overexpression on capillary morphogenesis. Thus, we have identified two signaling pathways regulated by VEGF in HUVECs that further our understanding of the process of angiogenesis and may provide novel targets for therapeutic intervention into diseases involving angiogenesis.
The Effects of Carcinogens and Irradiation on Cells and Tissues of the Eastern Red Spotted Newt (Notophthalmus viridescens)
Creators: name: Linklater, Stefanie K.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: Newt
Cancer
Carcinogen
Irradiation
Regeneration

description: Newts, such as Notophthalmus viridescens, can regenerate many structures after amputation or injury and have also shown a refractory response to the formation of cancer in tissues that have regenerative capabilities. The mechanisms behind this latter ability have surprisingly not been studied. In the current study, N. viridescens were exposed to a variety of carcinogens in tissue that cannot regenerate with the intention of inducing tumour formation. After testing multiple carcinogens, multiple sites of injection, and two different modes of delivery, no tumours were generated. Consequently, in vitro assays were developed in order to better understand this ability of newt cells to evade transformation. Mouse and newt muscle cells were exposed to DNA damaging agents, such as irradiation and carcinogens, in culture and their response was monitored with respect to the DNA damage response proteins γ-H2AX, p53, and phospho-p53. These proteins are important as they help prevent mutations in the genome from being passed on to daughter cells and potentially generating cells that proliferate uncontrollably, a hallmark of cancer. Preliminary results suggest that after irradiation, γ-H2AX is present in newt cells for a considerably longer period of time in comparison to mouse cells. p53, as well as phospho-p53, appear to be present at a basal level before and after irradiation in newt cells, whereas mouse cells have a distinct increase upon damage and decrease upon repair. The carcinogen treatments also suggest that newt cells have basal levels of expression of these proteins prior to treatment. These studies suggest that newt cells may have a unique profile of these DNA damage response proteins and may be “primed” to repair any future damage. This is a good first step in understanding what is likely a very complicated explanation for newts’ refractory response to cancer formation.
Medioevo, teorie storiografiche e oggetti intenzionali
Creators: name: Fedriga, Riccardo
Publisher: name: Doctor Virtualis
Year: 2010

description: Il medioevo cinematografico come oggetto essenzialmente teorico, ma dotato di una propria specifica forma di realtà, che ne fa qualcosa definibile, con terminologia fortemente medievale, come oggetto intenzionale.
description: Doctor Virtualis, N° 6 (2007): Un medioevo per il cinema: Intentio, Fictio
Language levels for the universal variability language : An Extension mechanism and conversion strategies
Creators: name: Vill, Stefan
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: variability modeling
subject: variability language
subject: unified language
subject: exchange format
subject: software product lines
subject: universal variability language
subject: Produktlinie
subject: DDC 620 / Engineering & allied operations
subject: UML (Computer science)
subject: Product lines
subject: Produktlinie

description: Feature models are commonly used to describe software product lines. There are different textual representations to describe a feature model, which leads to additional effort when using tools and feature models that use different languages. The Universal Variability Language (UVL) is a textual feature-modeling language. UVL is developed in close cooperation with the community with the goal to gain widespread adoption. The current version of UVL is rather simple, which makes it easy to understand and integrate into tools. However, this simple UVL version is not suitable for some use cases due to a lack of language features. An example that is difficult to represent as UVL feature model is a configurable computer, with the constraint that the accumulated power consumption of all parts must be lower than a certain threshold. If UVL adds explicit support to describe such a constraint, tools need to manage the added complexity to fully use UVL which again hampers exchange. The goals of being suitable for many use cases, but also easy to integrate into tools, contradict each other. We address this contradiction by adding optional language levels to UVL. This way, developers can integrate UVL into their tool and specify the language levels the tool supports. Tools that support different language levels are not interoperable by default. To improve exchangeability, we provide a set of basic conversion strategies to translate between language levels. Through conversion strategies, tools can use feature models, even if they do not fully support all UVL language level. As initial set of UVL language levels, we add support for expressions and equations over numerical attributes in constraints and feature cardinality to UVL. We provide tool support for parsing, printing, and conversion of feature models with a Java library. Our proposal makes UVL suitable for more use cases and reduces the effort when using UVL models across multiple tools.
Supplementary document for Deep learning of image- and time-domain data enhances visibility of structures in optoacoustic tomography - 5211163.pdf
Creators: name: Davoudi, Neda
name: Özbek, Ali
name: Lafci, Berkan
name: DEÁN-BEN, XOSÉ
name: Razansky, Daniel
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary Document