cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
MEASUREMENT AND MODELING OF SOOT FORMATION AND DEPOSITION IN FUEL RICH HIGH PRESSURE KEROSENE COMBUSTION
Creators: name: Kulakhmetov, Rufat
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Aerospace engineering not elsewhere classified

description: Combustion of kerosene propellants often deposits soot on chamber walls. These deposits act as a thermal barrier and can significantly affect the analysis of cooling systems. This is especially vital for reusable engines since the accumulated soot deposit can make the wall heat flux vary between every firing. This dissertation discusses a computational and experimental effort to understand the main drivers of these soot deposits. The computational approach employs the Method of Moments with Interpolative Closure (MOMIC) model to predict soot particle dynamics; Brownian and thermophoretic diffusion for particle transport to the chamber surface; and the Hydrogen-Abstraction-Acetylene-Addition (HACA) mechanism for soot surface growth. These models were incorporated in a 1D plug flow reactor. Two-dimensional axisymmetric reacting CFD simulations were also run to understand the flow field influence on the near wall gas phase chemistry. Simultaneously, a fuel rich kerosene and gaseous oxygen experiment was developed and fired to obtain soot deposit thickness measurements for model comparison. The results show the reduced order plug flow model can satisfactorily predict the soot thickness and that thermophoresis is the dominant deposition mechanism. However, though the model can predict deposit mass trends, it underpredicts the absolute values for some conditions and may need an additional mechanism.
Supplemental Material, sj-pdf-1-ppq-10.1177_13540688211029794 - Voters’ short-term responsiveness to coalition deals
Creators: name: Plescia, Carolina
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160607 International Relations
subject: FOS: Political science

description: Supplemental Material, sj-pdf-1-ppq-10.1177_13540688211029794 for Voters’ short-term responsiveness to coalition deals by Carolina Plescia in Party Politics
High-Frequency Murine Ultrasound Provides Enhanced Metrics of BAPN-Induced AAA Growth
Creators: name: Romary, Daniel J
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Biomedical engineering not elsewhere classified
Biomechanical engineering
Clinical microbiology
Cardiology (incl. cardiovascular diseases)

description: An abdominal aortic aneurysm (AAA), defined as a pathological expansion of the largest artery in the abdomen, is a relatively common disease that frequently leads to death if rupture occurs. Once diagnosed, clinicians often evaluate the rupture risk based on the maximum diameter of the aneurysm, a limited metric that is not accurate for all patients. In this study, we worked to provide additional distinguishing factors between growing and stable AAAs to aid in clinical rupture risk assessment. We utilized a relatively new murine model that uses surgical application of topical elastase to cause initial aortic expansion, and a lysyl oxidase inhibitor, β-aminopropionitrile (BAPN), in the drinking water to promote AAA growth. We further sought to develop and demonstrate applications of advanced imaging approaches, including four-dimensional ultrasound (4DUS), to obtain and evaluate alternative geometric and biomechanical parameters between 1) growing AAAs, 2) stable AAAs, and 3) non-aneurysmal control mice. Our study confirmed the reproducibility of the model and found reduced strain values, greater tortuosity, and decreased elastin health in mice with aneurysms. We also found expanding murine AAAs to have increased peak wall stress and surface area per length compared to stable aneurysms. The results from this work help provide a better understanding of the growth patterns associated with elastase-BAPN murine aneurysms and demonstrate the capabilities of high-frequency ultrasound. Eventually these data could help lay the groundwork for improving insight into clinical prediction of AAA expansion.
Identifying signals of disproportionate reporting for calcitonin gene-related peptide inhibitors: real-world evidence from the FDA adverse event reporting system
Creators: name: Lee, Nai
name: Ok, Jihoon
name: Kwon, Yonghoon
name: Rhee, Su-jin
name: Kim, Yun
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Calcitonin gene-related peptide (CGRP) inhibitors have been FDA-approved for migraine prophylaxis and relief. However, their safety profile remains uncertain. This study analyzes adverse events (AEs) and signals of disproportionate reporting (SDRs) using the FDA Adverse Event Reporting System (FAERS). We analyzed FAERS reports from approval through Q2 2023, standardizing terms using preferred terminology and system organ class (SOCs) classifications. Disproportionality analyses (ROR, PRR, IC) identified SDRs and inclusion in FDA prescribing information was reviewed. Additional analyses included comparisons with other migraine drugs, indication-based sensitivity analyses and causality assessment using the Bradford Hill framework. Galcanezumab showed strong signals for underdose (ROR 47.4; 95% CI 43.79–51.3), alopecia (5.72; 5.09–6.43), and constipation (6.01; 5.35–6.75), while fremanezumab exhibited notable associations with alopecia (6.9; 5.72–8.33) and weight increased (6.34; 5.18–7.76). Among gepants, rimegepant was linked to somnolence (4.52; 3.57–5.73) and dizziness (3.73; 3.15–4.42) and atogepant showed a strong signal for therapy interruption (16.58; 12.86–21.38). This study highlights CGRP inhibitor-associated AEs, underscoring the need for clinical monitoring and risk identification. Early detection of AEs and SDRs can inform protective measures to enhance patient safety.
A-Hypergeometric Systems and D-Module Functors
Creators: name: Steiner, Avram W
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Pure mathematics not elsewhere classified

description: Let A be a d by n integer matrix. Gel'fand et al.\ proved that most A-hypergeometric systems have an interpretation as a Fourier–Laplace transform of a direct image. The set of parameters for which this happens was later identified by Schulze and Walther as the set of not strongly resonant parameters of A. A similar statement relating A-hypergeometric systems to exceptional direct images was proved by Reichelt. In the first part of this thesis, we consider a hybrid approach involving neighborhoods U of the torus of A and consider compositions of direct and exceptional direct images. Our main results characterize for which parameters the associated A-hypergeometric system is the inverse Fourier–Laplace transform of such a "mixed Gauss–Manin system".
If the semigroup ring of A is normal, we show that every A-hypergeometric system is "mixed Gauss–Manin".
In the second part of this thesis, we use our notion of mixed Gauss–Manin systems to show that the projection and restriction of a normal A-hypergeometric system to the coordinate subspace corresponding to a face are isomorphic up to cohomological shift; moreover, they are essentially hypergeometric. We also show that, if A is in addition homogeneous, the holonomic dual of an A-hypergeometric system is itself A-hypergeometric. This extends a result of Uli Walther, proving a conjecture of Nobuki Takayama in the normal homogeneous case.
sj-docx-1-joo-10.1177_14653125211029959 – Supplemental material for Patient reported experiences and treatment outcomes of orthodontic patients treated within secondary care settings in the South West of England during the COVID-19 pandemic
Creators: name: Jopson, Jenifer L
name: Ellis, Pamela E
name: Jerreat, Amelia S
name: Kneafsey, Louise C
name: Moore, Matthew B
name: Day, Christian
name: Scott, Julia K
name: Griffiths, Helen
name: Lee, Tara VN
name: Oliver, Graham R
name: Fowler, Peter V
name: Sherriff, Martyn
name: Ireland, Anthony J
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine

description: Supplemental material, sj-docx-1-joo-10.1177_14653125211029959 for Patient reported experiences and treatment outcomes of orthodontic patients treated within secondary care settings in the South West of England during the COVID-19 pandemic by Jenifer L Jopson, Pamela E Ellis, Amelia S Jerreat, Louise C Kneafsey, Matthew B Moore, Christian Day, Julia K Scott, Helen Griffiths, Tara VN Lee, Graham R Oliver, Peter V Fowler, Martyn Sherriff and Anthony J Ireland in Journal of Orthodontics
sj-docx-1-anp-10.1177_00048674211025722 – Supplemental material for Insight in nonpsychotic disorders: A new model of insight and a systematic review of measures
Creators: name: Halaj, Asala
name: Huppert, Jonathan D
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: Neuroscience

description: Supplemental material, sj-docx-1-anp-10.1177_00048674211025722 for Insight in nonpsychotic disorders: A new model of insight and a systematic review of measures by Asala Halaj and Jonathan D Huppert in Australian & New Zealand Journal of Psychiatry
Review of studies evaluating the effectiveness of risk minimization measures for oncology medicinal products registered in the European Medicines Agency (HMA-EMA) catalogue: findings and lessons learned
Creators: name: Monteiro, Jorge
name: Almeida, Diogo
name: Fernandes, João Paulo
name: Sepodes, Bruno
name: Torre, Carla
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Risk management in oncology is critical due to toxicity, narrow therapeutic windows, and strict dosing schedules. This study analyzed post-authorization studies from the HMA-EMA Real-World Data Catalogues evaluating the effectiveness of risk minimization measures (RMM) for oncology medicines. We reviewed all RMM effectiveness studies registered in the HMA-EMA RWD Catalogues until February 2024, focusing on medicines classified under ATC codes ‘L’ and ‘V10’ for oncological conditions. Data from protocols and reports were analyzed, including study design, population, objectives, RMM types, process and outcomes indicators and reported effectiveness. Out of 1,280 records, 21 studies met the inclusion criteria. Most studies (81%) were cross-sectional surveys, 57% targeted healthcare professionals, and 86% used primary data. Additional RMMs were evaluated in 81% of studies. Process indicators were assessed in nearly all studies, but only 5% included outcome indicators. Of the 15 studies with available results, 60% were deemed effective, 27% inconclusive, and 13% ineffective by the sponsors. Future studies should set success thresholds in advance, use a dual evidence approach to measure outcomes, and consider new methods to increase participant numbers. Feasibility assessments prior to conducting studies are essential for achieving meaningful objectives in oncology risk management.
Additional file 2 of Malaria infection among adults residing in a highly endemic region from the Democratic Republic of the Congo
Creators: name: Kayiba, Nadine Kalenda
name: Nitahara, Yuko
name: Tshibangu-Kabamba, Evariste
name: Mbuyi, Denis Kalambayi
name: Kabongo-Tshibaka, Augustin
name: Kalala, Nestor Tshituka
name: Tshiebue, Barthélemy Mukenga
name: Candray-Medina, Katherine-Sofia
name: Kaku, Natsuko
name: Nakagama, Yu
name: Speybroeck, Niko
name: Mumba, Dieudonné Ngoyi
name: Disashi, Ghislain Tumba
name: Kaneko, Akira
name: Kido, Yasutoshi
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Additional file 2. Survey Questionnaire
Evaluation of Prebiotic and Probiotic as Functional Feed Additives on Physiological and Immunological Parameters of Nile Tilapia, Oreochromis niloticus
Creators: name: Saillant, Kenneth E
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Animal immunology
Animal physiology - systems

description: Experiments were conducted to evaluate the ability of prebiotic and probiotic supplementation of commercial fish feed to improve the physiological, immunological, and growth responses of stressed Nile tilapia. To investigate these objectives, tilapia were divided in two major groups: control fish (fed regular commercial feed) and stressed fish (induced by dietary cortisol supplemented to regular commercial feed). Stressed fish were further divided into three sub-groups: stressed fish fed regular feed, stressed fish fed probiotic-supplemented feed, and stressed fish fed a mixture of prebiotic and probiotic supplemented feed. Fish were maintained and tested over an eight-week long experimental period. A variety of physiological, immunological, and growth parameters were measured over the course of the experimental period. These parameters include: serum cortisol, blood glucose, plasma protein, packed cell volume, hepato-somatic index (HSI), spleen-somatic index (SSI), lysozyme activity, feed conversion ratio (FCR), specific growth rate (SGR), protein efficiency ratio (PER), length gain, weight gain, length gain, and condition factor (K). The results of this study does not support the use of these specific prebiotic and probiotic as functional feed additives in Nile tilapia at the levels tested in this study. Further research is needed to determine which probiotic species are best suited for use in Nile tilapia and which prebiotic, when used in combination, will allow these probiotics to have maximum effect.
Pathogenese der Legionelleninfektion
Creators: name: Flieger, Antje
name: Banerji, S.
name: Broich, M.
name: Rydzewski, Kerstin
name: Shadrach, W. S.
Publisher: name: Robert Koch-Institut
Year: 2003
Subjects: subject: Legionelleninfektion
subject: Pathogenese
subject: 610 Medizin

description: Legionellen sind Gram-negative Bakterien, die im Süßwasser als intrazelluläre Parasiten von Protozoen vorkommen. Nach Inhalation besiedelt das Bakterium Alveolarmakrophagen und alveoläre Epithelzellen der Lunge. Beim Menschen kann insbesondere die Spezies Legionella pneumophila die Legionärskrankheit, eine schwere Pneumonie, auslösen, die oft einen Funktionsverlust der Lunge zur Folge hat. In den letzten Jahren wurde eine Reihe von bakteriellen Faktoren beschrieben, die die intrazelluläre Vermehrung und Virulenz fördern. Unter diesen befindet sich das Typ-II-Protein-Sekretionssystem Lsp von L. pneumophila, das hydrolytische Enzyme, wie z.B. die Zink-Metalloprotease, saure Phosphatasen, Phospholipasen A und Lysophospholipasen A transportiert. Im Moment ist noch nicht vollständig geklärt,welche dieser exportierten Faktoren die eigentlichen Effektoren von intrazellulärer Vermehrung und Virulenz sind.Phospholipase- Aktivität wurde bei Bakterien (z.B. Pseudomonas aeruginosa, Listeria monocytogenes, Yersinia enterocolitica) als einer der maßgeblichen Pathogenitätsfaktoren charakterisiert. Somit könnte die Phospholipase- A-Aktivität von L. pneumophila z.B. über die Zerstörung von alveolärem Lungenepithel, Alveolarmakrophagen und Lungensurfactant zur Pathogenese einer Legionelleninfektion beitragen. Die Forschungsvorhaben der Nachwuchsgruppe "Pathogenese der Legionelleninfektion" haben zum Ziel, neue Pathogenesemechanismen von Legionellen zu charakterisieren und sollen gleichzeitig versuchen, neue Therapiemethoden über die Inhibition von hydrolytischen Enzymen zu etablieren.
sj-docx-1-jdr-10.1177_00220345211018182 – Supplemental material for Using Proanthocyanidin as a Root Dentin Conditioner for GIC Restorations
Creators: name: Cai, J.
name: Burrow, M.F.
name: Manton, D.J.
name: Palamara, J.E.A.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine
subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, sj-docx-1-jdr-10.1177_00220345211018182 for Using Proanthocyanidin as a Root Dentin Conditioner for GIC Restorations by J. Cai, M.F. Burrow, D.J. Manton and J.E.A. Palamara in Journal of Dental Research
ИЧКИ ИШЛАР ОРГАНЛАРИ ҲУҚУҚБУЗАРЛИКЛАР ПРОФИЛАКТИКАСИ БЎЛИНМАЛАРИНИНГ ЖАМОАТЧИЛИК БИЛАН ҲАМКОРЛИГИНИНГ МУВОФИҚЛАШТИРИШГА ОИД ХОРИЖИЙ ДАВЛАТЛАР ТАЖРИБАСИ
Creators: name: Ниматов, Шерзод
Publisher: name: Zenodo
Year: 2024

description: Жамиятда тинчлик ва осойишталикни сақлаш, жамоат тартиби ва хавфсизлигини таъминлаш, фуқароларнинг ҳуқуқ ва эркинлшшарини ҳар қандай тажовузлардан ҳимоя килишдек юксак мақсадларга эришиш учун истиқлол йилларида ички ишлар органлари тизимини чуқур ислоҳ қилиш бўйича кенг кўламли ишлар амалга оширилди.
Post-marketing safety assessment of constipation drugs: a real-world pharmacovigilance study based on FAERS database
Creators: name: Zhang, Wenyu
name: Wang, Hui
name: Yang, Shiwei
name: Pang, Xue
name: Hu, Wenqi
name: Zhang, Guang
name: Xin, Xuezhi
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Laxatives are widely used in the treatment of constipation, but they also have brought many adverse reactions to patients. We conducted a pharmacovigilance analysis based on the United States Food and Drug Administration Adverse Event Reporting System (FAERS) database to analyze the adverse events of six constipation drugs (linaclotide, lubiprostone, prucalopride, naloxegol, naldemedine, and plecanatide) and to search for clinically meaningful adverse reaction signals. We used disproportionality analysis as the main analysis method to detect pharmacovigilance signals, which includes Frequentist methods and Bayesian methods. Among the reports of the six drugs, more adverse reactions were reported from females than males, and the number of adverse reactions reported was higher in the group of 60–89 years. Linaclotide had the lowest proportion of serious adverse event reports (4.38%), while naldemedine had the highest proportion of serious adverse event reports (25.57%). According to the classification of system organ classification (SOC), the number of gastrointestinal adverse events (N = 8321) was the largest. The adverse reactions of constipation drugs were mainly gastrointestinal symptoms such as diarrhea, abdominal pain and abdominal distension. Linaclotide has the highest safety, and more studies are needed to analyze the cardiovascular safety of lubiprostone.
Vorausberechnungen des Herzinfarktgeschehens in Deutschland
Creators: name: Wiesner, Gerd
name: Grimm, J.
name: Bittner, Edelgard
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2002
Subjects: subject: Herzinfarkt
subject: Deutschland
subject: Inzidenz
subject: Prävalenz
subject: Vorausberechnung
subject: Germany
subject: Prevalence
subject: Incidence
subject: Heart Attack
subject: Prediction
subject: 610 Medizin

description: Auf der Grundlage des Bundes-Gesundheitssurveys 1998, des Augsburger Herzinfarktregisters und der 9. koordinierten Bevölkerungsvorausberechnung erfolgte eine Vorausberechnung des Herzinfarktgeschehens in der Bundesrepublik Deutschland bis zum Jahre 2050. Allein aus demographischer Perspektive wird sich ungeachtet medizinischer und sozialer Einflussfaktoren der kardiologische Versorgungsbedarf beträchtlich erhöhen. Unter der theoretischen Voraussetzung eines gleichbleibenden Erkrankungsrisikos bzw. einer gleichbleibenden Häufigkeit des Krankseins steigt insgesamt im Projektionszeitraum von 1998 bis 2050 die Zahl der inzidenten bzw. prävalenten Herzinfarktfälle im Alter von 25 bis >90 Jahre bzw. 35 bis
description: Based on the Federal Health Survey from 1998, the Augsburg heart attack registry, and the ninth coordinated population prediction, we have estimated the occurrence of heart attacks in Germany up to the year 2050. From the mere demographic perspective – regardless of medical and social influences – we can expect that the need for cardiac care will increase considerably. If we assume that the risk or the frequency of having a heart attack will remain the same, then the number of heart attacks in people aged 25 to over 90 and 35 to under 90 will increase, although the population size of these age groups will decline. The population over 75 years of age will with certainty determine the course of the incidence and prevalence of heart attacks. In addition to standardised incidence and/or prevalence rates, estimations of the absolute number of incidents and/or prevalent cases of the respective target illness have to be included in morbidity predictions in order to avoid misinterpretations.
sj-pdf-1-hss-10.1177_15563316211029837 – Supplemental material for Comparing the Efficacy of Radiation Free Machine-Vision Image-Guided Surgery With Traditional 2-Dimensional Fluoroscopy: : A Randomized, Single-Center Study
Creators: name: Dorilio, Jessica
name: Utah, Nicole
name: Dowe, Christina
name: Avrumova, Fedan
name: Alicea, Daniel
name: Brecevich, Antonio
name: Callanan, Tucker
name: Sama, Andrew
name: Lebl, Darren R.
name: Abjornson, Celeste
name: Cammisa, Frank P.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110323 Surgery
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-1-hss-10.1177_15563316211029837 for Comparing the Efficacy of Radiation Free Machine-Vision Image-Guided Surgery With Traditional 2-Dimensional Fluoroscopy: : A Randomized, Single-Center Study by Jessica Dorilio, Nicole Utah, Christina Dowe, Fedan Avrumova, Daniel Alicea, Antonio Brecevich, Tucker Callanan, Andrew Sama, Darren R. Lebl, Celeste Abjornson and Frank P. Cammisa in HSS Journal®: The Musculoskeletal Journal of Hospital for Special Surgery
Additional file 1 of An impact study of the Iranian National University Entrance Exam from students and parents’ perspectives
Creators: name: Ahmadi Safa, Mohammad
name: Sheykholmoluki, Hamidreza
Publisher: name: figshare
Year: 2024
Subjects: subject: Sociology
subject: FOS: Sociology

description: Additional file 1:Appendix A. Iranian National University Entrance Exam (INUEE) Impact Questionnaire. Appendix B. Interview questions for parents. Appendix C. The results of rotated factor matrix (PCA with Varimax rotation) and communalities. Appendix D. Descriptive statistics for the items of the INUEE questionnaire.
Direct Demand Estimation for Bus Transit in Small Cities
Creators: name: Shellhamer, Nathaniel J
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Transport planning
Civil engineering not elsewhere classified

description: Public transportation is vital for many people who do not have the means to use other forms of transportation. In small communities, transit service is often limited, due to funding constraints of the transit agency. In order to maximize the use of available funding resources, agencies strive to provide effective and efficient service that meets the needs of as many people as possible. To do this, effective service planning is critical. Unlike traditional road-based transportation projects, transit service modifications can be implemented over the span of just a few weeks. In planning for these short-term changes, the traditional four-step transportation planning process is often inadequate. Yet, the characteristics of small communities and the resources available to them limit the applicability of existing transit demand models, which are generally intended for larger cities. This research proposes a methodology for using population and demographic data from the Census Bureau, combined with stop-level ridership data from the transit agency, to develop models for forecasting transit ridership generated by a given geographic area with known population and socioeconomic characteristics. The product of this research is a methodology that can be applied to develop ridership models for transit agencies in small cities. To demonstrate the methodology, the thesis built ridership models using data from Lafayette, Indiana. A total of four (4) ridership models are developed, giving a transit agency the choice to select a model, based on available data and desired predictive power. More complex models are expected to provide greater predictive power, but also require more time and data to implement. Simpler models may be adequate where data availability is a challenge. Finally, examples are provided to aid in applying the models to various situations. Aggregation levels of the American Community Survey (ACS) data provided some challenge in developing accurate models, however, the developed models are still expected to provide useful information, particularly in situations where local knowledge is limited, or where additional information is unavailable.
Epidemiologische, genetische und therapeutische Aspekte der Adipositas
Creators: name: Willich, S. N.
name: Sharma, A. M.
name: Krasemann, E.O.
name: Meyer-Sabellek, W.
name: Thefeld, Wolfgang
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2001
Subjects: subject: Adipositas
subject: Body Mass Index
subject: Herz-Kreislauf-Erkrankungen
subject: Risikofaktor
subject: Obesity
subject: Cardiovascular diseases
subject: Risk factor
subject: 610 Medizin

description: Die Prävalenz von Adipositas (Body Mass Index ≥30 kg/m2) liegt in Deutschland für Männer bei 19,9% und für Frauen bei 21,6%, im Osten jeweils höher als im Westen. Medizinische Risiken bei Übergewicht sind vor allem die erhöhte Inzidenz von Risikofaktoren und Manifestationen der Herz-Kreislauf-Erkrankungen. Epidemiologische Untersuchungen zeigen zudem eine kontinuierliche Zunahme der Gesamtmortalität bereits ab Body Mass Index 25. In multivariaten Analysen erwies sich Adipositas unter Berücksichtigung von Hyperlipoproteinämie, Hypertonie und Diabetes als ein unabhängiger signifikanter Risikofaktor für koronare Herzkrankheit, Herzinsuffizienz, Schlaganfall und plötzlichen Herztod. Genetische Aspekte spielen bei der Entwicklung von Adipositas eine wichtige Rolle. Die Ergebnisse bisheriger Interventionsstudien sind weitgehend enttäuschend. Nach wie vor gilt: “Most obese persons will not stay in treatment, most will not lose weight, and of those who lose weight, most will regain it”. (“Die meisten adipösen Personen bleiben nicht in Behandlung, die meisten verlieren kein Gewicht und von denen, die Gewicht verlieren, nehmen die meisten wieder zu”.) Die Akzeptanz von Adipositas als ernst zu nehmende Erkrankung wird zur Entwicklung wirksamer und dauerhafter Therapie- und Präventionsstrategien beitragen.
description: In Germany, the prevalence of obesity (body mass index ≥30 kg/m2) in men is 19,9% and in women 21,6%. In both groups the prevalence is higher in the easter compared to the western part of Germany. Obesity leads to the risk factors and manifestation of cardiovascular diseases. In addition, epidemiologic investigations indicate a continous increase in mortality, already starting at a body mass index of 25. In multivariate analyses, obesity proved as an independent significant risk factor for coronary heart disease, heart failure, stroke, and sudden cardiac death after adjustment for hyperlipidemia, high blood pressure and diabetes. Genetic aspects play an important role in the development of obesity. To a large extent, the results of previous intervention studies have been disappointing. Still it holds: “Most obese persons will not stay in treatment, most will not lose weight, and of those who lose weight, most will regain it”. The acceptance of obesity as a serious disorder will contribute to the development of effective and long-lasting therapeutic and preventive strategies.
Review of studies evaluating the effectiveness of risk minimization measures for oncology medicinal products registered in the european medicines agency (HMA-EMA) catalogue: findings and lessons learned
Creators: name: Monteiro, Jorge
name: Almeida, Diogo
name: Fernandes, João Paulo
name: Sepodes, Bruno
name: Torre, Carla
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Risk management in oncology is critical due to toxicity, narrow therapeutic windows, and strict dosing schedules. This study analyzed post-authorization studies from the HMA-EMA Real-World Data Catalogues evaluating the effectiveness of risk minimization measures (RMM) for oncology medicines. We reviewed all RMM effectiveness studies registered in the HMA-EMA RWD Catalogues until February 2024, focusing on medicines classified under ATC codes ‘L’ and ‘V10’ for oncological conditions. Data from protocols and reports were analyzed, including study design, population, objectives, RMM types, process and outcomes indicators and reported effectiveness. Out of 1,280 records, 21 studies met the inclusion criteria. Most studies (81%) were cross-sectional surveys, 57% targeted healthcare professionals, and 86% used primary data. Additional RMMs were evaluated in 81% of studies. Process indicators were assessed in nearly all studies, but only 5% included outcome indicators. Of the 15 studies with available results, 60% were deemed effective, 27% inconclusive, and 13% ineffective by the sponsors. Future studies should set success thresholds in advance, use a dual evidence approach to measure outcomes, and consider new methods to increase participant numbers. Feasibility assessments prior to conducting studies are essential for achieving meaningful objectives in oncology risk management.
Additional file 1 of Slip distribution of the 2024 Noto Peninsula earthquake (MJMA 7.6) estimated from tsunami waveforms and GNSS data
Creators: name: Fujii, Yushiro
name: Satake, Kenji
Publisher: name: figshare
Year: 2024
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences
subject: Geophysics

description: Additional file 1: Fig. S1. Comparison of the observed and calculated tsunami waveforms from the joint inversion of tsunami waveform and GNSS data for the JSPJ fault models. The thick black and gray lines are the observed waveforms used and not used in the inversion, respectively. The red lines show the synthetic tsunami waveforms from the joint inversion, with the thick parts used in the inversion. The blue lines show the computed waveforms from the inversion using only tsunami waveform data. Synthetic waveforms from the joint inversion and the tsunami waveform inversion are indistinguishable except at Wajima WG station. The gray bars below the waveforms indicate the time windows used in the inversions. Fig. S2. Same as Fig. S1. but for a case adopting the MLIT fault models. Fig. S3. Same as Fig. 2, but for a case adopting the MLIT fault models. Fig. S4. Same as Fig. 3, but for a case adopting the MLIT fault models. Table S1. Fault parameters of the MLIT models and the inversion results.
sj-docx-3-sat-10.1177_11782218211033298 – Supplemental material for Changes in Alcohol Habits Among Workers During the Confinement of COVID-19: Results of a Canadian Cross-Sectional Survey
Creators: name: Mongeau-Pérusse, Violaine
name: Rizkallah, Elie
name: Bruneau, Julie
name: Chênevert, Denis
name: Menvielle, Loick
name: Jutras-Aswad, Didier
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, sj-docx-3-sat-10.1177_11782218211033298 for Changes in Alcohol Habits Among Workers During the Confinement of COVID-19: Results of a Canadian Cross-Sectional Survey by Violaine Mongeau-Pérusse, Elie Rizkallah, Julie Bruneau, Denis Chênevert, Loick Menvielle and Didier Jutras-Aswad in Substance Abuse: Research and Treatment
DIAMETERS AND VELOCITIES FOR CHARGED LIQUID DROPS UNDERGOING AERODYNAMIC BREAKUP
Creators: name: Yang, Ze
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Aerospace engineering not elsewhere classified
Mechanical engineering not elsewhere classified

description: The sizes and velocities of fragments resulting from the aerodynamic breakup of charged drops are reported here. Measurements were made using digital inline holography (DIH). Highly and moderate conductive liquid droplets are used. Uncertainty of parameters is discussed. Finally, a discussion on the applied potential used for possible fragment charge-to-mass ratio charge is presented.
Der SF-36 im Bundes-Gesundheitssurvey Erste Ergebnisse und neue Fragen
Creators: name: Bellach, Bärbel-Maria
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2000
Subjects: subject: Gesundheitssurvey
subject: Morbidität
subject: Gesundheitsbezogene Lebensqualität
subject: Zufriedenheit
subject: Health survey
subject: Morbidity
subject: Health Related Quality of Life HRQOL
subject: Satisfaction
subject: 610 Medizin

description: Im Rahmen des Bundes-Gesundheitssurveys 1998 wurde der international erprobte Fragebogen SF-36 (Short Form 36) zur Messung der Lebensqualität eingesetzt. Die Anwendung dieses Instruments bei einer repräsentativen Bevölkerungserhebung von Gesundheitsparametern und Gesundheitsverhalten erschließt weitaus mehr Möglichkeiten, als die der Bereitstellung einer neuen Normstichprobe und deren Beschreibung. Es können sehr komplexe Fragen zum Zusammenhang von Morbidität, Zufriedenheit, Risikofaktoren, Schichtzugehörigkeit, Alter und Geschlecht einerseits und der subjektiv eingeschätzten gesundheitsbezogenen Lebensqualität andererseits untersucht werden. Erste Auswertungsergebnisse der Surveydaten werden exemplarisch vorgestellt. Dies gibt nicht nur Einblicke in die subjektive Wahrnehmung von Gesundheit durch die Probanden, sondern demonstriert auch Möglichkeiten und Grenzen des Instruments SF-36 zur Messung gesundheitsbezogener Lebensqualität auf Bevölkerungsebene.
description: Within the framework of the National Health Interview and Examination Survey 1998 the Short Form Questionnaire SF-36 has been applied to measure the health related quality of life (HRQOL). This opened more opportunities than simply creating a new normative sample for the German adult population. Thus, the very complex interdependence between morbidity, satisfaction, risk factors, health related behaviours, social status, age and sex on the one side and the subjective assessment of health related quality of life on the other hand may be investigated. First results of the Survey data are presented which open the discussion of the possibilities and limits of the SF-36 instrument for measuring health related quality of life at the population level.
sj-pdf-1-inq-10.1177_00469580211022968 – Supplemental material for Do Medicare’s Facility Fees Incentivize Hospitals to Vertically Integrate with Oncologists?
Creators: name: Valdez, Samuel
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-1-inq-10.1177_00469580211022968 for Do Medicare’s Facility Fees Incentivize Hospitals to Vertically Integrate with Oncologists? by Samuel Valdez in INQUIRY: The Journal of Health Care Organization, Provision, and Financing
Mary’s Play: T. S. Eliot, Emily Hale, and The Family Reunion
Creators: name: Whittier-Ferguson, John
Publisher: name: Humanities Commons
Year: 2020
Subjects: subject: Eliot, T. S. (Thomas Stearns), 1888-1965
subject: Drama

description: A paper for the T. S. Eliot and Emily Hale panel (385 - T. S. Eliot and Emily Hale) that looks at Eliot's newly unsealed correspondence with Emily Hale, particularly during the year 1937, alongside the character of Mary in Eliot's 1939 play, The Family Reunion. The paper argues for the centrality of Mary to Eliot's ambitions for a new kind of drama and discusses why Eliot can't allow her to continue the trajectory he places her on at the end of the first act.
sj-docx-8-tam-10.1177_17588359211022905 – Supplemental material for Oral vinorelbine and cisplatin as first-line therapy for advanced squamous NSCLC patients: a prospective randomized international phase II study (NAVoTrial 03)
Creators: name: Grossi, Francesco
name: Jaśkiewicz, Piotr
name: Ferreira, Marion
name: Czyżewicz, Grzegorz
name: Kowalski, Dariusz
name: Ciuffreda, Libero
name: Garcia-Gomez, Ramon
name: Caruso, Salvatore
name: Bosch-Barrera, Joaquim
name: Gautier, Stéphanie
name: Ta Thanh Minh, Christine
name: Henriet, Sébastien
name: de Castro, Gilberto
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 110203 Respiratory Diseases

description: Supplemental material, sj-docx-8-tam-10.1177_17588359211022905 for Oral vinorelbine and cisplatin as first-line therapy for advanced squamous NSCLC patients: a prospective randomized international phase II study (NAVoTrial 03) by Francesco Grossi, Piotr Jaśkiewicz, Marion Ferreira, Grzegorz Czyżewicz, Dariusz Kowalski, Libero Ciuffreda, Ramon Garcia-Gomez, Salvatore Caruso, Joaquim Bosch-Barrera, Stéphanie Gautier, Christine Ta Thanh Minh, Sébastien Henriet and Gilberto de Castro in Therapeutic Advances in Medical Oncology
Additional file 1 of α-Synuclein-carrying astrocytic extracellular vesicles in Parkinson pathogenesis and diagnosis
Creators: name: Wang, Pan
name: Lan, Guoyu
name: Xu, Bin
name: Yu, Zhenwei
name: Tian, Chen
name: Lei, Xia
name: Meissner, Wassilios G.
name: Feng, Tao
name: Yang, Ying
name: Zhang, Jing
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Environmental Sciences not elsewhere classified

description: Additional file 1. Fig. S1. Characterization of overexpression of A53T α-syn and aggregated α-syn in primary astrocytes. Fig. S2. The levels of neuron-derived L1CAM positive EVs carrying total α-syn in plasma of PD, MSA, and HC groups. Fig. S3. The effect of a-syn on the function of the lysosome in primary astrocytes. Fig. S4. Full-length western blots. Fig. S5. The correlation of the level of α-syn-carrying astrocytic EVs with gender as well as MDS-UPDRS III.
Mapping low intake of micronutrients across Europe
Creators: name: Mensink, Gert
name: Fletcher, Reg
name: Gurinovic, M.
name: Huybrechts, I.
name: Lafay, L.
name: Serra-Majem, Lluis
name: Szponar, Lucjan
name: Tetens, Inge
name: Verkaik-Kloosterman, J.
name: Baka, A.
name: Stephen, A. M.
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2013
Subjects: subject: Dietary surveys
subject: Europe
subject: Micronutrients
subject: Inadequacies
subject: Nutrient requirements
subject: 610 Medizin

description: Achieving an understanding of the extent of micronutrient adequacy across Europe is a major challenge. The main objective of the present study was to collect and evaluate the prevalence of low micronutrient intakes of different European countries by comparing recent nationally representative dietary survey data from Belgium, Denmark, France, Germany, The Netherlands, Poland, Spain and the United Kingdom. Dietary intake information was evaluated for intakes of Ca, Cu, I, Fe, Mg, K, Se, Zn and the vitamins A, B1, B2, B6, B12, C, D, E and folate. The mean and 5th percentile of the intake distributions were estimated for these countries, for a number of defined sex and age groups. The percentages of those with intakes below the lower reference nutrient intake and the estimated average requirement were calculated. Reference intakes were derived from the UK and Nordic Nutrition Recommendations. The impact of dietary supplement intake as well as inclusion of apparently low energy reporters on the estimates was evaluated. Except for vitamin D, the present study suggests that the current intakes of vitamins from foods lead to low risk of low intakes in all age and sex groups. For current minerals, the study suggests that the risk of low intakes is likely to appear more often in specific age groups. In spite of the limitations of the data, the present study provides valuable new information about micronutrient intakes across Europe and the likelihood of inadequacy country by country.
A screening tool to prioritize public health risk associated with accidental or deliberate release of chemicals into the atmosphere
Creators: name: Blakey, David H.
name: Lafontaine, Marc
name: Lavigne, Jocelyn
name: Sokolowski, Danny
name: Philippe, Jean-Marc
name: Sapori, Jean-Marc
name: Biederbick, Walter
name: Horre, Regine
name: Marzi, Willi B.
name: Kondo, Hisayoshi
name: Kuroki, Yumiko
name: Namera, Akira
name: Okumura, Tetsu
name: Yamamoto, Miyako
name: Yashiki, Mikio
name: Blain, Peter G.
name: Russell, David R.
name: Cibulsky, Susan M.
name: Jett, David A.
Publisher: name: Robert Koch-Institut
Year: 2013
Subjects: subject: Public health
subject: Risk assessment
subject: Chemicals
subject: Atmospheric releases
subject: Screening tool
subject: Disaster management cycle
subject: 610 Medizin

description: The Chemical Events Working Group of the Global Health Security Initiative has developed a flexible screening tool for chemicals that present a risk when accidentally or deliberately released into the atmosphere. The tool is generic, semi-quantitative, independent of site, situation and scenario, encompasses all chemical hazards (toxicity, flammability and reactivity), and can be easily and quickly implemented by non-subject matter experts using freely available, authoritative information. Public health practitioners and planners can use the screening tool to assist them in directing their activities in each of the five stages of the disaster management cycle.
Automation of the Supine Pressor Test for Preeclampsia
Creators: name: Qureshi, Hamna
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Biomedical instrumentation
Biomedical engineering not elsewhere classified

description: Preeclampsia leads to increased risk of morbidity and mortality for both mother and fetus. Most previous studies have largely neglected mechanical compression of the left renal vein by the gravid uterus as a potential mechanism. In this study we first used a murine model to investigate the pathophysiology of left renal vein constriction. The results indicate that prolonged renal vein stenosis after 14 days can cause renal necrosis and an increase in blood pressure (BP) of roughly 30 mmHg. The second part of this study aimed to automate a diagnostic tool, known as the supine pressor test (SPT), to enable pregnant women to assess their preeclampsia development risk. A positive SPT has been previously defined as an increase of at least 20 mmHg in diastolic BP when switching between left lateral recumbent and supine positions. The results from this study established a baseline BP increase between the two body positions in non-pregnant female subjects and demonstrated the feasibility and utility of an automated SPT in pregnant women. Our results demonstrate that there is a baseline increase in BP of roughly 10-14 mmHg and that pregnant women can autonomously perform the SPT. Overall, this work in both rodents and humans suggests that 1) stenosis of the left renal vein in mice leads to elevation in BP and acute renal failure, 2) non-pregnant women experience a baseline increase in BP when they shift from left lateral recumbent to supine position, and 3) the SPT can be automated and used autonomously.
Population level survival of patients with chronic myelocytic leukemia in Germany compared to the US in the early 21st century
Creators: name: Pulte, Dianne
name: Barnes, Benjamin
name: Jansen, Lina
name: Eisemann, Nora
name: Emrich, Katharina
name: Gondos, Adam
name: Hentschel, Stefan
name: Holleczek, Bernd
name: Kraywinkel, Klaus
name: Brenner, Hermann
Publisher: name: Robert Koch-Institut
Year: 2013
Subjects: subject: Survival
subject: Prognosis
subject: Chronic myeloid leukemia
subject: Period analysis
subject: 610 Medizin

description: Introduction: The advent of tyrosine kinase inhibitors has produced 5-year survival of 90 + % for chronic myelocytic leukemia (CML) patients in clinical trials. However, population level survival has been lower, especially in older patients. Here, we examine survival of patients with CML in Germany and compare it to survival of patients in the United States (US). Methods: Data were extracted from the Surveillance, Epidemiology, and End Results database in the US and 11 cancer registries in Germany. Patients 15–69 years old diagnosed with CML were included in the analysis. Period analysis for 2002–2006 was used to provide the most up-to-date possible estimates of five-year relative survival. Results: Five-year relative survival was 68.7% overall in Germany and 72.7% in the US. Survival was higher in the US for all age groups except for ages 15–39 years, but the difference was only statistically significant for ages 50–59 years (at 67.5% vs 77.7% in Germany and the US, respectively). Survival decreased with age, ranging from 83.1% and 81.9%, respectively, in Germany and the US for patients 15–39 years old to 54.2% and 54.5%, respectively, in patients 65–69 years old. Survival increased between 2002 and 2006 by 12.0% points in Germany and 17.1% points in the US. Conclusions: Five-year survival estimates were higher in the US than in Germany overall, but the difference was only significant for ages 50–59 years. Survival did not equal that seen in clinical trials for either country, but strong improvement in survival was seen between 2002 and 2006.