cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Novel chemometric and computational methods for modelling cardiovascular metabolic phenotypic data
Creators: name: Dos Santos Correia, Goncalo
Publisher: name: Imperial College London
Year: 2016

description: Metabolic phenotyping, the analysis of the chemical content of human tissue and biofluid samples with either NMR or MS profiling, holds great potential for diagnostics, patient stratification and as a molecular epidemiology approach. But for this potential to be fulfilled, adequate bioinformatic and computational methodologies are required to help extract information from the vast amounts of complex data generated by the analytical platforms, whose high-throughput capacity, phenotypic coverage and cost-effectiveness are ever increasing. The work described in this thesis strives to contribute to this necessary development of bioinformatic work-flows and data analysis methods with the aim of assisting in the processing, analysis, interpretation and design of metabolic phenotyping studies and approaches. Special emphasis was given to the development of bioinformatic solutions for the pre- processing of very high-throughput direct infusion mass spectrometry assays, the adaptation of curve-fitting workflows for the automated annotation and quantification of metabolites from the proton NMR spectra of human serum and plasma biofluid, and to the development of computational and simulation methodologies for the design of metabolic phenotyping studies. The main outcomes of the work described in this thesis were the development of a python open source software for efficient handling and analysis of large direct infusion mass spectrometry datasets, the demonstration of the feasibility and the advantage of applying BATMAN, an automated curve fitting open source software for the routine analysis of NMR spectra of human blood products, and finally, the development of flexible methodologies for sample size determination, power analysis and design of metabolic phenotyping studies.
Figure S1 from Voltage-gated sodium channel gene repertoire of lampreys: gene duplications, tissue-specific expression and discovery of a long-lost gene
Creators: name: Zakon, Harold H.
name: Weiming Li
name: Pillai, Nisha E.
name: Sumanty Tohari
name: Shingate, Prashant
name: Jianfeng Ren
name: Byrappa Venkatesh
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Neuroscience
subject: Evolutionary Biology
subject: FOS: Biological sciences

description: Studies of the voltage-gated sodium (Nav) channels of extant gnathostomes have made it possible to deduce that ancestral gnathostomes possessed four voltage-gated sodium channel genes derived from a single ancestral chordate gene following two rounds of genome duplication early in vertebrates. We investigated the Nav gene family in two species of lampreys (the Japanese lamprey, Lethenteron japonicum and sea lamprey, Petromyzon marinus) (jawless vertebrates—agnatha) and compared them with those of basal vertebrates to better understand the origin of Nav genes in vertebrates. We noted six Nav genes in both lamprey species but orthology with gnathostome (jawed vertebrate) channels was inconclusive. Surprisingly, the Nav2 gene, ubiquitously found in invertebrates and believed to have been lost in vertebrates, is present in lampreys, elephant shark (Callorhinchus milii) and coelacanth (Latimeria chalumnae). Despite repeated duplication of the Nav1 family in vertebrates, Nav2 is only in single copy in those vertebrates in which it is retained, and was independently lost in ray-finned fishes and tetrapods. Of the other five Nav channel genes, most were expressed in brain, one in brain and heart, and one exclusively in skeletal muscle. Invertebrates do not express Nav channel genes in muscle. Thus, early in the vertebrate lineage Nav channels began to diversify and different genes began to express in heart and muscle.
nanoo.tv PRO - Market Entry Strategy for Swiss SMEs
Creators: name: Anderegg, Gina
name: Kriech, Michael
name: Moser, Delia
name: Siegrist, Alice
name: Studer, Chantal
Publisher: name: Hochschule für Wirtschaft FHNW
Year: 2016
Subjects: subject: Market Entry Strategy
subject: Product Launch
subject: New Market
subject: Market Introduction
subject: 330 - Wirtschaft

description: The company, Werft22 AG, aims to introduce their product, nanoo.tv PRO, to the market of Swiss small and medium-sized enterprises (SMEs). The product provides all the necessary support for companies to store and manage their video material on one single platform. By means of this Live Project, the Project Group has been entrusted to undertake the first steps of a Market Entry Strategy for nanoo.tv PRO.
Mother grooming of offspring and non-offspring in post-conflict versus non-conflict intervals from Limited evidence for third-party affiliation during development in wild chimpanzees (Pan troglodytes schweinfurthii)
Creators: name: Miller, Jordan A.
name: Stanton, Margaret A.
name: Lonsdorf, Elizabeth V.
name: Wellens, Kaitlin R.
name: A. Catherine Markham
name: Murray, Carson M.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 60801 Animal Behaviour
subject: FOS: Biological sciences

description: Histogram of 10,000 proportions of non-conflict intervals in which mothers groomed A) offspring and B) non-offspring. PC = Average proportion of PC intervals in which an offspring or non-offspring was groomed. NC = Bootstrapped mean of proportions in which an offspring or non-offspring was groomed in a random non-conflict interval.
MOESM1 of Periostin involved in the activated hepatic stellate cells-induced progression of residual hepatocellular carcinoma after sublethal heat treatment: its role and potential for therapeutic inhibition
Creators: name: Zhang, Rui
name: Lin, Xia-Hui
name: Ma, Min
name: Chen, Jie
name: Chen, Jun
name: Gao, Dong-Mei
name: Cui, Jie-Feng
name: Chen, Rong-Xin
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Plant Biology

description: Additional file 1: Table S1. Primers for quantitative RT-PCR.
Figure S5 from Voltage-gated sodium channel gene repertoire of lampreys: gene duplications, tissue-specific expression and discovery of a long-lost gene
Creators: name: Zakon, Harold H.
name: Weiming Li
name: Pillai, Nisha E.
name: Sumanty Tohari
name: Shingate, Prashant
name: Jianfeng Ren
name: Byrappa Venkatesh
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Neuroscience
subject: Evolutionary Biology
subject: FOS: Biological sciences

description: Studies of the voltage-gated sodium (Nav) channels of extant gnathostomes have made it possible to deduce that ancestral gnathostomes possessed four voltage-gated sodium channel genes derived from a single ancestral chordate gene following two rounds of genome duplication early in vertebrates. We investigated the Nav gene family in two species of lampreys (the Japanese lamprey, Lethenteron japonicum and sea lamprey, Petromyzon marinus) (jawless vertebrates—agnatha) and compared them with those of basal vertebrates to better understand the origin of Nav genes in vertebrates. We noted six Nav genes in both lamprey species but orthology with gnathostome (jawed vertebrate) channels was inconclusive. Surprisingly, the Nav2 gene, ubiquitously found in invertebrates and believed to have been lost in vertebrates, is present in lampreys, elephant shark (Callorhinchus milii) and coelacanth (Latimeria chalumnae). Despite repeated duplication of the Nav1 family in vertebrates, Nav2 is only in single copy in those vertebrates in which it is retained, and was independently lost in ray-finned fishes and tetrapods. Of the other five Nav channel genes, most were expressed in brain, one in brain and heart, and one exclusively in skeletal muscle. Invertebrates do not express Nav channel genes in muscle. Thus, early in the vertebrate lineage Nav channels began to diversify and different genes began to express in heart and muscle.
Effect of Celebrity Endorsement on Consumer’s Perception of Corporate Image, Corporate Credibility and Corporate Loyalty (Case Study: Novin Charm Company)
Creators: name: Ghotbivayghan, Bahareh
name: Shahri, Masoumeh Hosseinzadeh
name: Mohammadreza Ebrahimi
Publisher: name: figshare
Year: 2020
Subjects: subject: 150301 Business Information Management (incl. Records, Knowledge and Information Management, and Intelligence)
subject: FOS: Economics and business

description: Nowadays, the use of celebrity endorsement in product marketing and advertising is one of
the major factors in companies’ promotion strategies. Celebrities as one of the major tools in
advertising can lead to encourage consumers to use specific products and corporate loyalty
because of their special and unique abilities or characteristics.
Study result show that the celebrity endorsement has a positive effect on corporate image,
corporate credibility and corporate loyalty. Moreover corporate image have a positive effect
on corporate credibility and corporate credibility have a positive effect on corporate loyalty.
Pelvic kinematics as confounding factor for cam hip impingement
Creators: name: Hardijzer, Antoinette
Publisher: name: Imperial College London
Year: 2017

description: The purpose of this thesis was to explore a range of biomechanical factors linked to the development of symptoms and potentially early onset hip OA in people with cam hip impingement. This was achieved through shape analysis on 3D bone models (segmented from medical images), and motion analysis performed during walking and squatting. Following ethical approval, kinematic and morphological variables were obtained from 19 pre-operative hip impingement patients and 18 healthy controls, and these were compared between groups. Patients demonstrated reduced neck-shaft-angles (-6.0°, p
Contribution of physical activity to the increased risk of type-2 diabetes in UK South Asians compared to Europeans.
Creators: name: Afaq, Saima
Publisher: name: Imperial College London
Year: 2017

description: Background: South Asians have ~3 times excess risk of T2D and related metabolic disturbances compared to Europeans. The known dietary, adiposity and genetic risk factors do not explain this excess risk of T2D in South Asians compared to Europeans. Contribution of physical activity to the increased T2D risk in South Asians remains undetermined. Methods: I determined the accuracy of three physical activity accelerometers amongst South Asians and Europeans. I estimated physical activity levels amongst UK South Asian and European men and women, using accelerometers, and investigated the association of physical activity with T2D, insulin resistance and related glycaemic disturbances by using univariate and multivariate analyses. Results: Energy expenditure Measured by the three accelerometers, in all the positions evaluated, was lower compared to Actual energy expenditure. Difference between Measured and Actual energy expenditure was smallest for the Actigraph GT3X+ in the ankle position compared to all other device-position combinations, amongst both South Asians and Europeans. Total physical activity, as determined by Actigraph GT3X+, was ~31% lower amongst South Asians compared to Europeans (P=0.01). After adjusting for age, sex and adiposity, an increase in physical activity was associated with reduced risk of T2D, insulin resistance and associated glycaemic disturbances (all P<0.05). Incidence of T2D was 13.4% amongst South Asians and 4.6% amongst Europeans in the LOLIPOP cohort over mean 9 years’ follow-up (P<0.001). The age, sex and adiposity adjusted relative risk of T2D reduced from 3.3 (95% CI: 2.9-3.7, P=1.1 x 10-75) to 2.3 (95% CI: 2.0-2.7, P=4.5 x 10-35) after adjusting for total physical activity levels. The T2D population attributable risk (%) for achieving less than 600 MET.minutes per week was ~16% in South Asians and ~37% in Europeans. Conclusions: The results show that accelerometers are as effective in measuring physical activity in South Asians as they are in Europeans and Actigraph GT3X+ is the most accurate device for measuring physical activity in the two populations. My findings suggest the potential for increased physical activity to improve glucose metabolism and insulin resistance, which predict T2D risk, amongst South Asians and help reduce their excess risk of T2D and its related complications. However, an increase in physical activity alone is unlikely to bridge the 3-fold excess risk of T2D in South Asians compared to Europeans.
Epigenetic reprogramming and mitotic chromosome structure
Creators: name: Kohler, Anne-Celine
Publisher: name: Imperial College London
Year: 2017

description: The epigenetic memory of a cells defines its identity. Upon reprogramming towards pluripotency a somatic cell undergoes epigenetic remodeling in order to become pluripotent. The work I am presenting here is divided into two parts. In the first part, I am using cell fusion mediated reprogramming to investigate Xi reactivation, a typical example of epigenetic remodeling, as well as how ploidy affects reprogramming efficiency. Among all the technique established for in vitro reprogramming towards pluripotency, cell fusion has the advantage of allowing us to study early events of reprogramming as well as having a higher efficiency compared to induced Pluripotent Stem cells (iPS). Despites intensive research on the molecular mechanisms and the epigenetic changes leading a somatic cell towards pluripotency, a lot remain unanswered. In this thesis, I showed that somatic cells were able to reprogram towards pluripotency and that some X-linked genes were reactivated upon reprogramming. I also demonstrated that haploid Embryonic Stem cells (ES) cells are able to reprogram somatic cells with a lower potential compared to diploid ES cells. This low reprogramming potential can be partially rescued by overexpression of Nanog. In the second part of my thesis, I focused on setting up a technique to visualize chromatin and aimed at studying the structure of mitotic chromosomes 19 using high resolution microscopy techniques such as Structured Illumination Microscopy (SIM) and cryo-Electron Microscopy (cryo-EM). Higher order chromatin structure remains unknown in mitosis. During mitosis, chromatin become highly compacted to form a mitotic chromosome. In order to isolate a specific chromosome (chromosome 19), first I reestablished flow karyotyping technique to sort the chromosomes 19. I also showed that chromosomes after sorting retained a certain degree of compaction as well as protein important for centromeric integrity such as Centromere Protein A (CENPA). To validate the isolation of mitotic chromosomes and the use of cryo-EM in chromosomes structure analysis, I assessed the compaction of mitotic chromosomes 19 upon loss of cohesin. Chromosomes 19 lacking Rad21 cohesin subunit possess a larger area and their chromatin looked more decondensed compared to mitotic chromosomes 19 with cohesin. This promising tool could be used in the future to study how epigenetic modifications affect chromatin structure.
Kinder- und Jugendhilfe und LGBTIQ*
Creators: name: Mangold, Katharina
name: Rein, Angela
Publisher: name: Springer
Year: 2021
Subjects: subject: Kinder- und Jugendhilfe
subject: LGBTIQ*
subject: 370 - Erziehung, Schul- und Bildungswesen

description: Der Beitrag führt in den Schwerpunkt ein und skizziert dabei dessen Zielsetzung, indem er die Texte und deren Akzentuierung kurz vorstellt.
Figure S3 from Voltage-gated sodium channel gene repertoire of lampreys: gene duplications, tissue-specific expression and discovery of a long-lost gene
Creators: name: Zakon, Harold H.
name: Weiming Li
name: Pillai, Nisha E.
name: Sumanty Tohari
name: Shingate, Prashant
name: Jianfeng Ren
name: Byrappa Venkatesh
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Neuroscience
subject: Evolutionary Biology
subject: FOS: Biological sciences

description: Studies of the voltage-gated sodium (Nav) channels of extant gnathostomes have made it possible to deduce that ancestral gnathostomes possessed four voltage-gated sodium channel genes derived from a single ancestral chordate gene following two rounds of genome duplication early in vertebrates. We investigated the Nav gene family in two species of lampreys (the Japanese lamprey, Lethenteron japonicum and sea lamprey, Petromyzon marinus) (jawless vertebrates—agnatha) and compared them with those of basal vertebrates to better understand the origin of Nav genes in vertebrates. We noted six Nav genes in both lamprey species but orthology with gnathostome (jawed vertebrate) channels was inconclusive. Surprisingly, the Nav2 gene, ubiquitously found in invertebrates and believed to have been lost in vertebrates, is present in lampreys, elephant shark (Callorhinchus milii) and coelacanth (Latimeria chalumnae). Despite repeated duplication of the Nav1 family in vertebrates, Nav2 is only in single copy in those vertebrates in which it is retained, and was independently lost in ray-finned fishes and tetrapods. Of the other five Nav channel genes, most were expressed in brain, one in brain and heart, and one exclusively in skeletal muscle. Invertebrates do not express Nav channel genes in muscle. Thus, early in the vertebrate lineage Nav channels began to diversify and different genes began to express in heart and muscle.
Additional file 1 of Reducing glucoamylase usage for commercial-scale ethanol production from starch using glucoamylase expressing Saccharomyces cerevisiae
Creators: name: Wang, Xin
name: Liao, Bei
name: Li, Zhijun
name: Liu, Guangxin
name: Diao, Liuyang
name: Qian, Fenghui
name: Yang, Junjie
name: Jiang, Yu
name: Zhao, Shumiao
name: Li, Youguo
name: Yang, Sheng
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1. Supporting information.
Figure S4 from Voltage-gated sodium channel gene repertoire of lampreys: gene duplications, tissue-specific expression and discovery of a long-lost gene
Creators: name: Zakon, Harold H.
name: Weiming Li
name: Pillai, Nisha E.
name: Sumanty Tohari
name: Shingate, Prashant
name: Jianfeng Ren
name: Byrappa Venkatesh
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Neuroscience
subject: Evolutionary Biology
subject: FOS: Biological sciences

description: Studies of the voltage-gated sodium (Nav) channels of extant gnathostomes have made it possible to deduce that ancestral gnathostomes possessed four voltage-gated sodium channel genes derived from a single ancestral chordate gene following two rounds of genome duplication early in vertebrates. We investigated the Nav gene family in two species of lampreys (the Japanese lamprey, Lethenteron japonicum and sea lamprey, Petromyzon marinus) (jawless vertebrates—agnatha) and compared them with those of basal vertebrates to better understand the origin of Nav genes in vertebrates. We noted six Nav genes in both lamprey species but orthology with gnathostome (jawed vertebrate) channels was inconclusive. Surprisingly, the Nav2 gene, ubiquitously found in invertebrates and believed to have been lost in vertebrates, is present in lampreys, elephant shark (Callorhinchus milii) and coelacanth (Latimeria chalumnae). Despite repeated duplication of the Nav1 family in vertebrates, Nav2 is only in single copy in those vertebrates in which it is retained, and was independently lost in ray-finned fishes and tetrapods. Of the other five Nav channel genes, most were expressed in brain, one in brain and heart, and one exclusively in skeletal muscle. Invertebrates do not express Nav channel genes in muscle. Thus, early in the vertebrate lineage Nav channels began to diversify and different genes began to express in heart and muscle.
Subjects Biographical Information & Sample Sizes from Limited evidence for third-party affiliation during development in wild chimpanzees (Pan troglodytes schweinfurthii)
Creators: name: Miller, Jordan A.
name: Stanton, Margaret A.
name: Lonsdorf, Elizabeth V.
name: Wellens, Kaitlin R.
name: A. Catherine Markham
name: Murray, Carson M.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 60801 Animal Behaviour
subject: FOS: Biological sciences

description: Focal immature subjects and TPA sample sizes included in the analyses.
Determinants of unplanned admissions in children: investigating the relationship between primary care quality and health service use with unplanned admissions in children
Creators: name: Cecil, Elizabeth
Publisher: name: Imperial College London
Year: 2016

description: Introduction: High quality primary care is considered central to preventing avoidable health system waste such as unplanned short stay admissions (SSA) for minor conditions and alleviating health inequality. Recent policy changes in primary care (2004) may have impacted on provision, access and supply of GPs. This provides an ideal opportunity to study its role on keeping children healthy in the community. I aimed to quantify the impact of policy change; GP timeliness and access; and GP utilisation on potentially preventable admissions and health disparities in children. Methods: My studies included a segmented population based trends study design and a retrospective cohort design. I used national hospital and primary care administrative datasets, focusing on children aged ≤14 years between April 2000 and March 2013, in England. My primary outcome measures were SSA rates (<2 days stay) for chronic conditions and infectious illness; my secondary outcome emergency department (ED) visits. I investigated: the impact of 1) primary care policy change in 2004; 2) patients’ reported access to their GP; and 3) primary care utilization on unplanned health service use and reducing deprivation gradients. Results: There was a significant increase in the number of children being admitted with chronic conditions for a short stay after primary care policy changes (11% rate increase in year of change), but not for infectious illness. Children were less likely to visit EDs or be admitted for a chronic condition if their GP offered better access. Better preventive care reduced children’s risk of an unplanned admission and deprivation gradients were narrowed in children who regularly consulted their GP. Conclusion: Primary care plays a significant role in limiting use of urgent and unplanned health service use, particularly for deprived children and those with chronic conditions. Investment in primary care is vital in a time of epidemiological transition in children.
Just a little bit more legumes! Results of an online survey in Europe
Creators: name: Marette, Stéphan
name: Roosen, Jutta
name: Marette, Stéphan
name: Roosen, Jutta
Publisher: name: Unknown
Year: 2022
Subjects: subject: Consumer/Household Economics
subject: Crop Production/Industries
subject: Food Consumption/Nutrition/Food Safety
subject: consumer behavior
subject: legumes
subject: nutrition
subject: environment
subject: web survey

description: A web survey was conducted in France, Germany, Poland, and the UK to examine how providing information about the benefits of legumes could influence purchase intent. In each country, 600 participants were recruited in September 2020. First, participants answered a series of questions about their dietary habits. Second, they were asked about their intention to purchase lentils, before and after they read an informational message about the nutritional or environmental benefits of lentils. The results show that receiving this information significantly affected purchase intent, even if the impact was relatively small. Indeed, after this revelation of information, about 10% of participants expressed a change of mind regarding their purchase intent. This effect was dependent on product type (i.e. dried lentils vs lentil pasta) and information type (i.e. nutritional vs environmental benefits). Across countries and products, information about the food’s environmental benefits had often a greater impact on purchase intent than did information about the food’s nutritional benefits. After reading the informational messages, 25-42% of all the participants said they planned to eat more legumes in the future. As consumers choices are weak drivers for developing legumes cultivation, other instruments focusing on farmers incentives such as subsidies could be selected.
ATLAS ePartizipation: demokratische Stadtentwicklung
Creators: name: (:Unkn) Unknown
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2015
Subjects: ePartizipation
Stadtentwicklung
Partizipation
digitale Tools

description: Die Publikation präsentiert eine Bestandesaufnahme aktueller Partizipationsprojekte die mit eWerkzeugen operieren und bietet als Handbuch hilfreiche Inputs für die Entwicklung von neuen Projekten und den Einsatz von eWerkzeugen für eine partizipative Stadtplanung. Eine Publikation der FHNW, finanziert von der HABG
Predictive modelling of short term outcomes following systemic neo-adjuvant and adjuvant therapy in breast cancer
Creators: name: Randhawa, Sunreet Maneeta Kaur
Publisher: name: Imperial College London
Year: 2017

description: Chemotherapy in breast cancer is limited by a narrow therapeutic index. Toxicity from chemotherapy can be life threatening, henceforth biomarkers to predict side effects allowing treatment to be tailored for individual patients would enable improved patient outcomes. Side effects studied during this pilot study include neutropenia and subsequent complications, weight gain, fatigue and toxicity from all causes. Metabolites identified in each section not only offer the potential of a biomarker but also highlight perturbed physiological and metabolic pathways. Specifically, underlying mechanisms likely contributing to chemotherapy induced neutropenia are secondary to suppression of granulopoiesis by branched chain amino acid metabolites, altered cytotoxicity as a consequence of baseline inflammation and low baseline haematological results. Metabolites identified associated with weight gain indicate perturbations in energy expenditure pathways, which predispose and lead to weight gain during treatment. A metabolic framework generated from pre-treatment serum samples showed changes in fatty acids, glycerol, hypoxanthine and amino acids, reflecting perturbations in energy metabolism to be a major feature and causative factor in the development of chemotherapy related fatigue. In the study of all cause toxicity pre-treatment differences between fatty acids, ketones and branched chain amino acids predispose patients to development of greater toxicity and poorer QOL. This pilot study has identified several potential biomarkers that warrant future investigation.
Supplementary document for Multifunctional difluoroboron β-diketonate-based luminescent receiver for high-speed underwater wireless optical communication system - 6600118.pdf
Creators: name: Wang, Yue
name: Wang, Jian-Xin
name: Alkhazragi, Omar
name: Gutiérrez-Arzaluz, Luis
name: Zhang, Hua-Fan
name: Kang, Chun Hong
name: Ng, Tien Khee
name: Bakr, Osman
name: MOHAMMED, OMAR F.
name: Ooi, Boon
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: Uncategorized

description: This document includes the details about the material synthesis process, color-converter fabrication process, and the results of free-space and underwater optical communication.
Development of multi-modal endoscopic optical biopsy for laryngeal (head and neck) cancer screening
Creators: name: Tatla, Taranjit Singh
Publisher: name: Imperial College London
Year: 2017

description: The work presented in this thesis aimed to study the application of optical coherence tomography (OCT), fluorescence lifetime imaging microscopy (FLIM), polarization resolved (PR) imaging and hybrid multi / hyper-spectral / structured lighting (MS / SL) to investigate their potential for diagnostic contrast of diseased head and neck mucosal tissues, with a particular emphasis on head and neck (laryngeal) cancer. Initially, an ex vivo study utilising bench-top OCT was undertaken to provide a baseline reference data-set on mucosal sub-sites from a laryngectomy patient. Technical development and pre-clinical (phantom) testing of a novel, endoscopic miniaturized OCT arrangement followed, prior to single-centre, in vivo clinical trial of the prototype arrangement at the NHS site. The portable OCT platform was adapted for dual hand-held and endoscopic application within the ENT outpatient clinic, allowing evaluation and preliminary correlation of OCT images (larynx and skin) with histopathology sections. Design considerations and feedback to the technical team, for further optimization of the OCT platform, concluded this work-stream. FLIM application thereafter, also involved design considerations for portability and endoscopic adaptation, prior to single-site clinical application. Use was limited to ex vivo diseased tissues extracted from the larynx, nasal cavity and oropharynx, exclusively within the busy operating theatre environment. As with OCT, limited histopathology correlation allowed commentary on tissue contrast between laryngeal disease states and between other head and neck sub-site mucosal pathologies. Similarly for PR, MS and SL, portable imaging assemblies were installed and optimised for operating room-based endoscopic application. Both ex vivo and in vivo application across head and neck mucosal sub-sites, and across disease states, was performed and contrast patterns reported. All four optical modalities demonstrated useful and potentially complimentary optical contrast capabilities, providing critical pilot data for future co-assembly of a multi-modal, optical imaging platform for head and neck (cancer and non-cancer, endoscopic and topical) disease screening. In modular format, the same multi-modality optical imaging platform may support augmented vision during microscope and robot-assisted disease resection, optical needle biopsies, in vivo optical observation of disease pathogenesis, as well as allowing objective non-invasive optical characterization of response to pharmaceutical and other treatments.
Integration and visualisation of clinical-omics datasets for medical knowledge discovery
Creators: name: Homola, Daniel
Publisher: name: Imperial College London
Year: 2017

description: In recent decades, the rise of various omics fields has flooded life sciences with unprecedented amounts of high-throughput data, which have transformed the way biomedical research is conducted. This trend will only intensify in the coming decades, as the cost of data acquisition will continue to decrease. Therefore, there is a pressing need to find novel ways to turn this ocean of raw data into waves of information and finally distil those into drops of translational medical knowledge. This is particularly challenging because of the incredible richness of these datasets, the humbling complexity of biological systems and the growing abundance of clinical metadata, which makes the integration of disparate data sources even more difficult. Data integration has proven to be a promising avenue for knowledge discovery in biomedical research. Multi-omics studies allow us to examine a biological problem through different lenses using more than one analytical platform. These studies not only present tremendous opportunities for the deep and systematic understanding of health and disease, but they also pose new statistical and computational challenges. The work presented in this thesis aims to alleviate this problem with a novel pipeline for omics data integration. Modern omics datasets are extremely feature rich and in multi-omics studies this complexity is compounded by a second or even third dataset. However, many of these features might be completely irrelevant to the studied biological problem or redundant in the context of others. Therefore, in this thesis, clinical metadata driven feature selection is proposed as a viable option for narrowing down the focus of analyses in biomedical research. Our visual cortex has been fine-tuned through millions of years to become an outstanding pattern recognition machine. To leverage this incredible resource of the human brain, we need to develop advanced visualisation software that enables researchers to explore these vast biological datasets through illuminating charts and interactivity. Accordingly, a substantial portion of this PhD was dedicated to implementing truly novel visualisation methods for multi-omics studies.
A systems approach to identifying patient safety problems in arterial surgery
Creators: name: Lear, Rachael
Publisher: name: Imperial College London
Year: 2018

description: In the face of the oft-quoted dictum ‘primum non nocere’, it is now widely recognised that a significant number of patients come to harm whilst in hospital. A large body of evidence demonstrates that half of all harm events are preventable and the operating theatre appears to be the most common site for adverse events to occur. For patients undergoing arterial intervention, technical expertise and risk-factor management are clearly important in achieving excellent outcomes. Recent research in vascular surgery has focussed on volume-outcome relationships and the impact of advancements in endovascular intervention. By contrast, there is a relative lack of research examining the extraordinarily complex system within which patients with arterial disease are treated. This thesis aims to develop a broad understanding of system failures and their relationship with patient safety and outcomes in arterial surgery in the British NHS. In section I (chapter 1 and 2) the systems approach is outlined and discussed and the rationale for adopting this approach in arterial surgery is provided. Section II consists of three exploratory studies: chapter 3 presents a systematic review of the literature examining the impact of system factors on safety in arterial surgery; chapter 4 reports a mixed-methods study exploring surgeons’ perceptions of the causes of adverse events in arterial surgery; and chapter 5 presents a multi-centre study of safety culture in vascular operating departments in England. Section III provides an account of the LEAP study: a multi-centre study of system failures occurring during aortic intervention. The methods and main findings of the LEAP study are presented in chapters 6 and 7. Chapter 8 reports on the determinants of intraoperative system failures and the relationship between intraoperative failure and patient outcome. Chapter 9 summarises the main findings and limitations of this thesis, and discusses recommendations for practice and future research.
Additional file 1 of Distribution of chimeric antigen receptor-modified T cells against CD19 in B-cell malignancies
Creators: name: Ying, Zhitao
name: He, Ting
name: Wang, Xiaopei
name: Zheng, Wen
name: Lin, Ningjing
name: Tu, Meifeng
name: Xie, Yan
name: Ping, Lingyan
name: Zhang, Chen
name: Liu, Weiping
name: Deng, Lijuan
name: Wu, Meng
name: Feng, Feier
name: Leng, Xin
name: Du, Tingting
name: Qi, Feifei
name: Hu, Xuelian
name: Ding, Yanping
name: Lu, Xin-an
name: Song, Yuqin
name: Zhu, Jun
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Table 1. Distribution of CAR-T cells in NCG mice. Table 2. Tissue distribution parameters in NCG mice. Table 3. Distribution of CAR-T cells in tumor-bearing NCG mice. Table 4. Changes of CAR-T cells in the blood of patients over time. Table 5. CAR-T peak in the blood of patients during the therapy. Table 6. Sequences of primers and probes for CAR-T detection
Computational genomics of regulatory elements and regulatory territories
Creators: name: Tan, Ge
Publisher: name: Imperial College London
Year: 2017

description: Whole genome comparison of metazoan genomes reveals extremely high level of noncoding conservation over tens to hundreds of base pairs across distant species. These sequences are termed as conserved noncoding elements (CNEs). Arrays of conserved noncoding elements that span the loci of developmental regulatory genes and their span defines regulatory genomic blocks (GRBs). CNEs are currently known to be involved in transcriptional regulation and development as long-range enhancers. However, no molecular mechanism can yet explain their exceptional degree of conservation. As a first step towards the genome-wide study of these elements, I developed two R/Bioconductor packages CNEr and TFBSTools, to detect and analyse regulatory elements. Next, I designed a novel CNE detection pipeline for duplicated regions in the ameiotic Adineta vaga genome. Identification of CNEs in this genome suggests that the principal function of CNEs is regulation of developmental gene expression rather than copy number sensing. In addition, I performed a de novo genome annotation of European common carp Cyprinus carpio. This genome stands as an ideal candidate for comparative study of zebrafish genome. Its analysis revealed a wealth of previously undetected fish regulatory elements and their unexpectedly high level of conservation between the two genomes. Finally, I presented a computational method for the identification of GRB boundaries and prediction of the corresponding target genes under long-range regulation. The predicted target genes are implicated in developmental, transcriptional regulation and axon guidance. The disruption of regulation of these target genes is likely to cause complex diseases, including cancer. The GRB boundaries and predicted target genes are valuable resource for investigating developmental regulation and interpreting genome-wide association studies.
Table S1. Volume composition of prey types in predator scats over the irruption cycle. from Prey selection and dietary flexibility of three species of mammalian predator during an irruption of non-cyclic prey
Creators: name: Spencer, Emma E.
name: Newsome, Thomas M.
name: Dickman, Christopher R.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Environmental Science
subject: Ecology
subject: FOS: Biological sciences

description: Percentage volumetric composition of prey types in feral cat (Felis catus), red fox (Vulpes vulpes) and dingo (Canis dingo) scats, grouped across four different stages of an irruption and collected in the Simpson Desert, central Australia.
Relationship between brand and dealer loyalty in the agricultural equipment market
Creators: name: Feeney, Roberto
name: Harmath, Pedro
name: Ramoni-Perazzi, Josefa
name: Clay, Pablo Mac
name: Feeney, Roberto
name: Harmath, Pedro
name: Ramoni-Perazzi, Josefa
name: Clay, Pablo Mac
Publisher: name: Unknown
Year: 2022
Subjects: subject: Agribusiness
subject: Marketing
subject: FOS: Economics and business
subject: ag equipment firms and dealers
subject: agricultural producers
subject: brand loyalty
subject: dealer loyalty
subject: probit models

description: Agricultural equipment companies intend to understand agriculture producers’ buying behavior by answering questions such as how loyal producers are to brands and dealers, which have an important impact on their profitability. This paper addresses the problem of how loyal agricultural producers are to equipment brands and dealers. Using a combination of cluster analysis and probit models, we identified producers’ behavioral and attitudinal loyalty to brands and dealers and analyzed the factors that explain such loyalty. We also found a strong interdependence between brand and dealer loyalty and the significant value that dealer loyalty adds to the brands. Additionally, we present some management implications of developing brand recognition, understanding producers purchasing behavior, and segmenting producers. This paper’s contributions are the establishment and measurement of an ‘empirical’ definition of brand and dealer loyalty, the identification and quantification of the impact of the explanatory factors of brand and dealer loyalty, and the determination of a dual loyalty relationship between brand and dealer loyalty.
Additional file 1: of Alterations of brain local functional connectivity in amnestic mild cognitive impairment
Creators: name: Zhen, Dan
name: Xia, Wei
name: Yi, Zhong
name: Zhao, Pan
name: Zhong, Jian
name: Shi, Hai
name: Li, Hua
name: Dai, Zhen
name: Pan, Ping
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Neuroscience
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Criteria for objective assessment of methodological quality of individual studies. Notes: A maximum score of 20 for each study, allocated as per the criteria specified above. (DOCX 19 kb)
Politics and the City: Introduction to Special Issue
Creators: name: Savic, Selena
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2020
Subjects: city
politics
urbanization
non-city
posthuman

description: The challenge of this special issue in finding words and coming to terms with contemporary city and contemporary politics is amplified by the difficulty to pin point what and where exactly a city is and how can we perceive political activities in its context. We might be better off asking: what is not city today, which place on Earth is empty of city-ness? This special issue presents four contributions that proceed from the panel City, Civility and Post-political Models of Freedom and Conflict panel held in November 2018 as part of the Scaffolds international symposium organized by ALICE lab from the École polytechnique fédérale de Lausanne, supported by the C I.II.III.IV. A, the Kanal Centre Pompidou, and with the participation of several institutions and university departments from KU Leuven, ULB, TU Delft, and TU Vienna. Without pertaining to comprehensiveness, the present collection captures some points in the debate on city and civility informed by questions that originate in design and architecture.
Additional file 1 of Maresin 1 protects the liver against ischemia/reperfusion injury via the ALXR/Akt signaling pathway
Creators: name: Tang, Da
name: Fu, Guang
name: Li, Wenbo
name: Sun, Ping
name: Loughran, Patricia A.
name: Deng, Meihong
name: Scott, Melanie J.
name: Billiar, Timothy R.
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Plant Biology
subject: Virology

description: Additional file 1. Figure S1. In vitro toxicity profile of MaR1. Primary cultured mouse HCs and NPCs were exposed to escalating concentrations of Maresin 1 (MaR1), and cytotoxicity was evaluated using a CKK-8 assay. Figure S2. ALXR and LGR6 expression during hepatic I/Rinjury
Immature grooming and playing with mothers in post-conflict versus non-conflict intervals from Limited evidence for third-party affiliation during development in wild chimpanzees (Pan troglodytes schweinfurthii)
Creators: name: Miller, Jordan A.
name: Stanton, Margaret A.
name: Lonsdorf, Elizabeth V.
name: Wellens, Kaitlin R.
name: A. Catherine Markham
name: Murray, Carson M.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 60801 Animal Behaviour
subject: FOS: Biological sciences

description: Histogram of 10,000 proportions of non-conflict intervals in which an immature A) groomed or B) played with his/her mother obtained from a randomization procedure for individuals of age class 1.5 – 5.0, 5.0 – 8.0, 8.0 – 12.0. PC = Average proportion of PC intervals in which the mother was groomed or played with. NC = Bootstrapped mean of proportions in which the mother was groomed or played with in a random non-conflict interval.
The role of business in responsibility to protect (R2P) in relation to the guiding principles of business and human rights and corporate social responsibility (CSR)
Creators: name: Nathan, Ganesh
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2015
Subjects: Responsibility to Protect (R2P)
Human Rights and Business
UN Global Compact
Corporate Social Responsibility
mass atrocities
Ruggie's framework

description: This paper attempts to explore whether there is a role for business in effectively contributing to the implementation of Responsibility to Protect (R2P) doctrine through the links between guiding principles of business and human rights which endorses Ruggie’s framework of respect, protect and remedy and the UN global compact within the umbrella term of corporate social responsibility (CSR). In response to the failures of preventing mass atrocities in Rwanda, Bosnia and Kosovo, despite having many conventions and charter on human rights, R2P framework was originally devised by the International Commission on Intervention and State Sovereignty in 2001 and later adapted by the UN (Alleblas, 2015). R2P was also pointed out as a necessity in the case of Syria crisis (Williams et al. 2012). It is a challenging doctrine with regard to intervention in the sovereignty of the state on mass atrocities. Although R2P acknowledges that the primary responsibility lies with the state, it also calls for other non-state actors of international community, including private businesses, to play a role in preventing mass atrocities within the state. There are practical examples to illustrate how private business could contribute to preventing mass atrocities such as Kenya Private Sector Alliance (KEPSA) (Alleblas, 2015). However, there is no clear guidance on how and why should private business actors contribute to R2P obligations. There are many research articles on conflict prevention and business; moreover, there is some correlation between conflict prevention and prevention of mass atrocities. However, further research is required on the importance of business and R2P in relation to the guiding principles on business and human rights framework which was recognized by the UN Human Rights Council in 2011 and the UN Global Compact (UNGC).
'Transcription Poetry as a Vehicle for Documenting the Lives of Disabled People' - conference paper for the Fifth International Disability Studies Conference, Lancaster University, UK, 2010
Creators: name: Sutherland, Allan
Publisher: name: BathSPAdata
Year: 2022
Subjects: Creative writing (incl. scriptwriting)
People with disability
Cultural and creative industries
Creative arts, media and communication curriculum and pedagogy

description: This conference paper was presented by Allan Sutherland at the Fifth International Disability Studies Conference, which took place at Lancaster University in September 2010. The paper describes Sutherland's working methods in transcription poetry up to that point and attempts to place this work in a historical context.
His previous experience in transcription poetry led to his involvement with the Electric Bodies project strand of D4D. This work is detailed elsewhere in the repository.

This content has been uploaded with the permission of the creator.