cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Thyroid hormone deiiodinases
Creators: name: Colquhoun, Eric Quentin
Publisher: name: University Of Tasmania
Year: 2023

description: Assay systems involving iodine-125 labelled iodothyronine substrates have been established which can detect deiodination with high sensitivity. A HPLC separation has also been established which complements the radiochemical assays. Using these assays, 5'-deiodinase enzyme activities have been localized to the plasma membranes, to the endoplasmic reticulum and to the lysosomes prepared from liver and kidney homogenates. A further activity in the cytosol of these tissues was also found, but evidence suggested, in part, that its presence there may be due to an artefact of the homogenisation procedures. Purification studies were performed on the cytosol 5'-deiodinase (because of its solubility) and on the combined microsomal 5'-deiodinase activity. Substantial purification (300 fold) of the 5'-deiodinase from cytosol was achieved using thyroxine as the ligand in affinity chromatography. Gel electrophoresis of this purified product suggested the presence of only a small number of proteins which combine in a regular fashion to produce aggregates of related structures. The combined plasma membrane and endoplasmic reticulum microsomal activity was significantly purified (3-10 fold) using iopanoic acid (which is a 5'-deiodinase inhibitor) as the ligand in affinity chromatography. The degree of purification compares favourably to that achieved by other workers. A model for deiodination of T4 is suggested in which the production of both T3 and rT 3 occurs predominantly at the plasma membrane. The rT 3 produced is then subject to rapid catabolism by deiodination in the lysosome. The rate of rT 3 deiodination by lysosomes is controlled by the inhibition or stimulation of lysosomal autophagy or changes in the lysosomal membrane or both by drugs, hormones or aminoacids. This leads to alterations in the intracellular levels of rT 3 which in turn feeds-back negatively on the plasma membrane enzyme (and also perhaps the endoplasmic reticulum deiodinase) to inhibit the production of T3. This then leads to a rise in plasma rT 3 followed soon after by a fall in plasma 13. It is further postulated that the final common pathway for dietary changes of rT 3 /T 3 levels is via the intracellular levels of aminoacids in the liver, especially those (e.g. Asn, Gln, Leu) which are gluconeogenic or anabolic. Finally drugs which are known to be lysomotrophic and markedly affect the stability of lysosomes are predicted to have effects on the ratio of rT3 to T3 found in plasma.
Modeling framework for dynamic pricing in macroscopic urban road networks
Creators: name: Katsifaraki, Georgia
Publisher: name: Zenodo
Year: 2024

description: We present a conceptual framework for applying pricing in macroscopic traffic networks, focusing on how traffic flows route themselves when path prices are utilized to manage demand at a macroscopic level. We define the minimum disutility mechanism that guides flows in macroscopic traffic networks, and illustrate the guiding process of flows under the effect of pricing, utilizing simple road network structures. The suggested mechanism forms the cornerstone of the conceptual framework for dynamic pricing in a macroscopic setting, as described herein. This framework highlights that, within a priced network, implementing a dynamic pricing policy to adjust path prices and equalize their disutilities can effectively distribute demand across both spatial and temporal dimensions. To ensure an efficient demand distribution, and thereby keep the network at the non-congested regime, an adequate availability of spatiotemporal paths is required however, both with and without perfect routing information.
title: Spirituality and People with Intellectual Disabilities: Comparing the Significance of Spirituality in Faith and Non-Faith Based Care Services
Creators: name: Sango, Precious N.
Publisher: name: University of Kent
Year: 2016

description: Background and Aim: The spiritual lives of people with ID has been under researched (Swinton, 2002; Turner et al., 2004) and as yet, no research has been carried out comparing faith-based and non-faith-based services for people with ID. This research explores and compares a faith-based care organisation with a non-faith based care organisation with the aim of investigating the significance of spiritual/religious based principles as modes of care to the quality of life of individuals, acknowledging that non-faith based care providers may provide ‘a spiritual/religious environment’, explicitly or non-explicitly. Method: A mixed-method design using both qualitative and quantitative methods was utilised. Six months were spent volunteering within each community in order to engage in participant observation of both care organisations. Quantitative methods included the Quality of Life Questionnaire; Self-esteem Scale and the Social Network Guide in addition to semi-structured interview schedules. Results: People with ID were found to enjoy spiritual/religious based activities, with spirituality being an important aspect of their quality of life. Staff from the non-faith based service provided religious spiritual care mainly through church attendance, whilst staff from the faith-based service provided both religious and non-religious spiritual care. Staff from both care services reported that practical implementation of spiritual/ religious care tended to be overridden by legalistic administrative tasks, communication issues and staff availability. Conclusion: There is a need for ID services to not only acknowledge but also facilitate spirituality in the lives of people with ID.
A survey of Eastern Australian and some other approaches to legislative control of off-road vehicles : lessons and proposals for Tasmania
Creators: name: Brown, Ross G
Publisher: name: University Of Tasmania
Year: 2023

description: Rapidly changing social patterns and increasing standards of living have brought about pronounced changes in the way in which leisure and recreation time is utilized. This, combined with rapid technological innovation in vehicle capabilities and manouverability, has brought about a dramatic increase in human use pressure on the natural environment. Despite the relatively short time in which the incidence of off-road vehicle impacts have been monitored and documented, there already exists a large body of literature (particularly North American) detailing the adverse and long term impacts of unrestricted vehicle use. That problems involving off-road recreational vehicles in Tasmania occur as regularly as they do suggests that Tasmanian land use management is failing to ensure that recreation vehicles are strictly controlled in confined areas or restricted to properly designed trails. The frustrations of the land manager are continually experienced by the author himself, through personal experience in bushland management with the Parks and Recreation Department, Hobart City Council. Persons caught driving illegally off-road usually protest ignorance of the relevant vehicular restrictions. All, however, indicate a common problem by asking: \where can I legally go?\" That dilemma the author as the owner of an endro motor-bike has also experienced when seeking off-road opportunities. The plethora of Tasmanian legislation dealing with the management of Crown land contains provisions for regulation and control of recreation vehicles. Despite this officers in the land management field are still confronted with enforcement problems. Indications elsewhere are that specific control measures must be implemented. It is argued drawing on lessons from the states of mainland Australia (and elsewhere) that problems posed by off-road recreational vehicles can be best ameliorated by the formulation of strict guidelines for land administering authorities to follow in drawing up regulations for application to recreational use of vehicles on public land. It is also argued that Tasmania should introduce specific legislation possibly based on similar legislation elsewhere in Australia or overseas (perhaps the USA in particular where considerable planning and legislation for off-road recreational vehicles has already been effected). A 'bundle' of strategies is suggested. Initially a policy and strategy with definite objectives must be formulated. Specific legislation while necessary must be backed by determined enforcement and prosecution. Just as important is the role of education in changing community attitudes. Control provisions which foster the latter objective require urgent implementation."
Potential of Onchocerca ochengi inosine-5′-monophosphate dehydrogenase (IMPDH) and guanosine-5′-monophosphate oxidoreductase (GMPR) as druggable and vaccine candidates: immunoinformatics screening
Creators: name: Gaiya, Daniel Danladi
name: Muhammad, Aliyu
name: Aimola, Idowu Asegame
name: Udu, Stella Kuyet
name: Balarabe, Sallau Abdullahi
name: Auta, Richard
name: Ekpa, Emmanuel
name: Sheyin, Abraham
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Onchocerciasis is a vector-borne disease caused by the filarial nematode Onchocerca volvulus, which is responsible for most of the visual impairments recorded in Africa, Asia and the Americas. It is known that O. volvulus has similar molecular and biological characteristics as Onchocerca ochengi in cattle. This study was designed to screen for immunogenic epitopes and binding pockets of O. ochengi IMPDH and GMPR ligands using immunoinformatic approaches. In this study, a total of 23 B cell epitopes for IMPDH and 7 B cell epitopes for GMPR were predicted using ABCpred tool, Bepipred 2.0 and Kolaskar and Tongaonkar methods. The CD4+ Th computational results showed 16 antigenic epitopes from IMPDH with strong binding affinity for DRB1_0301, DRB3_0101, DRB1_0103 and DRB1_1501 MHC II alleles while 8 antigenic epitopes from GMPR were predicted to bind DRB1_0101 and DRB1_0401 MHC II alleles, respectively. For the CD8+ CTLs analysis, 8 antigenic epitopes from IMPDH showed strong binding affinity to human leukocyte antigen HLA-A*26:01, HLA-A*03:01, HLA-A*24:02 and HLA-A*01:01 MHC I alleles while 2 antigenic epitopes from GMPR showed strong binding affinity to HLA-A*01:01 allele, respectively. The immunogenic B cell and T cell epitopes were further evaluated for antigenicity, non-alllergernicity, toxicity, IFN-gamma, IL4 and IL10. The docking score revealed favorable binding free energy with IMP and MYD scoring the highest binding affinity at −6.6 kcal/mol with IMPDH and −8.3 kcal/mol with GMPR. This study provides valuable insight on IMPDH and GMPR as potential drug targets and for the development of multiple epitope vaccine candidates. Communicated by Ramaswamy H. Sarma
Size-dependent melting: Numerical calculations of the phonon spectrum
Creators: name: Kang, Kai
name: Qin, Shaojing
name: Wang, Chuilin
Publisher: name: arXiv
Year: 2008
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: In order to clarify the relationship between the phonon spectra of nanoparticles and their melting temperature, we studied in detail the size-dependent low energy vibration modes. A minimum model with atoms on a lattice and harmonic potentials for neighboring atoms is used to reveal a general behavior. By calculating the phonon spectra for a series of nanoparticles of two lattice types in different sizes, we found that density of low energy modes increases as the size of nanoparticles decreases, and this density increasing causes decreasing of melting temperature. Size-dependent behavior of the phonon spectra accounts for typical properties of surface-premelting and irregular melting temperature on fine scales. These results show that our minimum model captures main physics of nanoparticles. Therefore, more physical characteristics for nanoparticles of certain types can be given by phonons and microscopic potential models.
description: 5 pages, 5 figures
Taxonomic and ecologic aspects of zoosporic fungi in coastal and steppe soils
Creators: name: Booth, Thomas
Publisher: name: University of British Columbia
Year: 2011

description: Certain criteria used to distinguish chytrid taxa are highly variable and unstable. This variability is evident from a study of ten single-spore isolates of an Entophlyctis species collected in Western Canada, Oregon, California and Nevada. The observed variations place these Entophlyctis isolates in different species, genera, subfamilies, families, and series, thus demonstrating that various current taxonomic dispositions and concepts are of questionable value. Zoosporic fungi, mainly Chytridiales, are widely distributed in coastal and steppe soils. Based on distributional records and determination of physical and chemical parameters for each soil collection, eleven chytrid and chytridiaceous species are divisible into four groups: a) obligately marine, b) marine, c) facultatively marine and d) marine occasionals. Certain aspects of this study are problematic which emphasizes the necessity of a more sophisticated line of approach. Temperature-salinity growth responses of fifty-seven axenic single-spore cultures of zoosporic fungi, maintained under similar controlled conditions for a minimum of six months, correlate with habitat types and certain environmental parameters. These responses, similar over several isolates of a species from the same soil collection, are temporally constant and, thus, are ecotypic.
Molecular dynamics simulations reveal the impact of NUDT15 R139C and R139H variants in structural conformation and dynamics
Creators: name: Gómez-Rubio, Elena
name: Garcia-Marin, Javier
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: NUDT15, also known as MTH2, is a member of the NUDIX protein family that catalyzes the hydrolysis of nucleotides and deoxynucleotides, as well as thioguanine analogues. NUDT15 has been reported as a DNA sanitizer in humans, and more recent studies have shown that some genetic variants are related to a poor prognosis in neoplastic and immunologic diseases treated with thioguanine drugs. Despite this, the role of NUDT15 in physiology and molecular biology is quite unclear, as is the mechanism of action of this enzyme. The existence of clinically relevant variants has prompted the study of these enzymes, whose capacity to bind and hydrolyze thioguanine nucleotides is still poorly understood. By using a combination of biomolecular modeling techniques and molecular dynamics, we have studied the monomeric wild type NUDT15 as well as two important variants, R139C and R139H. Our findings reveal not only how nucleotide binding stabilizes the enzyme but also how two loops are responsible for keeping the enzyme in a packed, close conformation. Mutations in α2 helix affect a network of hydrophobic and π-interactions that enclose the active site. This knowledge contributes to the understanding of NUDT15 structural dynamics and will be valuable for the design of new chemical probes and drugs targeting this protein. Communicated by Ramaswamy H. Sarma
Intellectual and Immaterial Bank (IIB): transformative processes and hybridization of skills via humor
Creators: name: Zaytseva, Anna
Publisher: name: Zenodo
Year: 2019
Subjects: humor
hybrid
breaking things
transformation
flat collaboration
distributed system
emerging jobs
future of jobs
blindness

description: Intellectual and Immaterial bank is a computational change agent in the form of a science-driven digital solution for several purposes: - facilitation of transformative processes in formation of emerging competences and jobs for future professionals and their individually informed uniqueness in the age of digitalization - facilitation of emergence and sustainable existence of flexible collaborating working environments - discovering, attracting and retaining lovely misfits, capable of recognizing and dealing with clashes and breaking frames for successful change and transformation in collaboration for achieving visions ...all that made by humor, funny, neutral simple jokes and visualizations via massive intelligent distributed infrastructure, were no unnecessary information – any facial data, unrelated to being capable – is ever shown, and the data belongs to the user that has actively generated it and can dispose it ...where both sides of the interaction – persons and collaborative environments – are treated in symmetry for their spontaneous, imperfect, but stimulating self-organization Welcome to our collaboration!
description: Funded by Innovation Norway
Heisenberg-Weyl algebra revisited: Combinatorics of words and paths
Creators: name: Blasiak, P.
name: Horzela, A.
name: Duchamp, G. H. E.
name: Penson, K. A.
name: Solomon, A. I.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The Heisenberg-Weyl algebra, which underlies virtually all physical representations of Quantum Theory, is considered from the combinatorial point of view. We provide a concrete model of the algebra in terms of paths on a lattice with some decomposition rules. We also discuss the rook problem on the associated Ferrers board; this is related to the calculus in the normally ordered basis. From this starting point we explore a combinatorial underpinning of the Heisenberg-Weyl algebra, which offers novel perspectives, methods and applications.
description: 5 pages, 3 figures
Submission for the degree of Doctor of Science
Creators: name: Bloom, Walter R
Publisher: name: University Of Tasmania
Year: 2023

description: My research lies in harmonic analysis, overlapping the areas of pure and applied mathematics, and over the last twenty years has developed along two major themes: (a) Abstract approximation and multiplier theory (b) Hypergroups and probability theory In addition I have been active in: (c) Mathematics education and other areas My work in abstract approximation and multiplier theory began with my doctoral studies on Bernstein's inequality for locally compact groups. An important breakthrough was to prove versions of this inequality based purely on properties of group translation, and without any reference to a differential structure. This led to versions of the Jackson and Bernstein theorems estimating the degree of approximation of smooth functions by partial sums of their Fourier series. An integral part of these developments was a study of multiplier theory for various related spaces of functions. During the past ten years my research has been in hypergroups and probability theory on these spaces. Much of this work has been done in collaboration with Herbert Heyer, and covers a study of the properties of the Fourier transform and convolution, through to the development of properties of positive definite and negative definite functions. As part of this work a major activity of the past five years has been the preparation (jointly with Herbert Heyer) of a substantial research monograph Harmonic analysis of probability measures on hypergroups which will be published by Walter de Gruyter publishers this year. This thesis covers those publications listed under (a) and (b) that have appeared in print.
Structure-Specific Scaling of Ground Motions for Estimating Peak Floor Accelerations in Multistory Buildings
Creators: name: Eren, Numan
name: Sucuoglu, Halȗk
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Neuroscience
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Mental Health
subject: Plant Biology
subject: FOS: Biological sciences

description: A structure-specific ground motion amplitude scaling procedure has been developed for reliable estimation of peak floor accelerations in multistory buildings. The introduced procedure is intended for the performance evaluation of acceleration-sensitive components attached to the floors of multistory frames. Floor accelerations are highly sensitive to high frequencies in base excitations. Accordingly, higher mode contributions to floor acceleration are considered explicitly in scaling the ground motions in this study. The ground motions scaled with the proposed procedure, and with two other scaling procedures are applied to two different 20-story concrete buildings. The results are evaluated comparatively through nonlinear response history analyses.
Introduction to Loop Quantum Gravity
Creators: name: Mercuri, Simone
Publisher: name: arXiv
Year: 2010
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The questions I have been asked during the 5th International School on Field Theory and Gravitation, have compelled me to give an account of the premises that I consider important for a beginner's approach to Loop Quantum Gravity. After a description of some general arguments and an introduction to the canonical theory of gravity, I review the background independent approach to quantum gravity, giving only a brief survey of Loop Quantum Gravity.
description: 91 pages, based on two invited lectures given at the 5th International School on Field Theory and Gravitation, April 20-24, 2009 Cuiaba city, Brazil
Jet Reconstruction with charged tracks only in CMS
Creators: name: Azzurri, Paolo
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The performance of jet finding using only charged tracks in CMS has been investigated. Different jet algorithms have been applied to QCD di-jet events, to hadronic tt multi-jet events and on Z+jets events. Results using jets made with tracks only or calorimeter towers are compared for energy response, angular resolution and jet matching to the leading partons. The jet reconstruction performance in the presence of pile-up interactions is presented for the Z+jets sample.
description: 4 pages, 3 figures, proceedings of Physics at LHC, 29 September - 4 October 2008, Split, Croatia
Quantum Biology
Creators: name: Sergi, Alessandro
Publisher: name: arXiv
Year: 2009
Subjects: subject: General Physics (physics.gen-ph)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Physical sciences

description: A critical assessment of the recent developments of molecular biology is presented. The thesis that they do not lead to a conceptual understanding of life and biological systems is defended. Maturana and Varela's concept of autopoiesis is briefly sketched and its logical circularity avoided by postulating the existence of underlying {\it living processes}, entailing amplification from the microscopic to the macroscopic scale, with increasing complexity in the passage from one scale to the other. Following such a line of thought, the currently accepted model of condensed matter, which is based on electrostatics and short-ranged forces, is criticized. It is suggested that the correct interpretation of quantum dispersion forces (van der Waals, hydrogen bonding, and so on) as quantum coherence effects hints at the necessity of including long-ranged forces (or mechanisms for them) in condensed matter theories of biological processes. Some quantum effects in biology are reviewed and quantum mechanics is acknowledged as conceptually important to biology since without it most (if not all) of the biological structures and signalling processes would not even exist. Moreover, it is suggested that long-range quantum coherent dynamics, including electron polarization, may be invoked to explain signal amplification process in biological systems in general.
Excitations of the $ν=5/2$ Fractional Quantum Hall State and the Generalized Composite Fermion Picture
Creators: name: Simion, George E.
name: Quinn, John J.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We present a generalization of the composite Fermion picture for a muticomponent quantum Hall plasma which contains particle with different effective charges. The model predicts very well the low-lying states of a $ν=5/2$ quantum Hall state found in numerical diagonalization.
description: 5 pages, 3 figures
Results on Top Quark Physics at D0
Creators: name: Peters, Y.
Publisher: name: arXiv
Year: 2008
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: In 1995, the top quark was discovered at the Fermilab Tevatron Collider by the CDF and D0 collaborations in the ppbar collisions at sqrt(s)=1.8 TeV using about 50pb^-1 of data per experiment. We present the studies of the top quark properties based on 1fb^-1 of data collected by the D0 experiment at a center of mass energy of 1.96TeV. The increased statistics and higher collision energy allow to perform precision measurements of the top quark production and decay characteristics and open the possibility to probe physics beyond the Standard Model in the top quark sector. The presentation mainly focuses on the measurement of the top pair production cross section and branching fraction of the top quark decays, a search for ttbar resonances, and the measurement of the top quark pair production cross section ratio and its interpretation in terms of new physics.
description: 5 pages, 4 figures, Submitted to the Proceedings of the Lake Louise Winter Institute, Top2008, 16-21 February 2008, Lake Louise, Canada
Statistical analysis of body surface electrocardiographic maps in ischemic heart disease
Creators: name: Bell, Anthony James
Publisher: name: University Of Tasmania
Year: 2023

description: Body surface electrocardiographic mapping is a technique for recording the thoracic electrical potentials generated by the cardiac cycle and transmitted to the body surface. The body surface map emphasizes the spatial distribution of the cardiac electrical potentials rather than the time magnitude relationship of the standard electrocardiogram. The body surface map contains more information than the standard electrocardiogram and in a different format. This thesis addresses the following questions: 1. is the additional information contained in the body surface map of clinical significance in myocardial infarction ? 2. is the display format and thus the application of topographical statistics of clinical benefit in myocardial infarction? 3. is the addition information able to detect coronary artery disease in patients presenting with chest pain ? Detailed analysis of the body surface map in acute inferior wall myocardial infarction predicted the clinical course of the patient, one map pattern being associated with a high mortality and morbidity, giving a guideline to immediate therapy. The area of ST segment elevation corresponds to the the area of eventual Q wave formation in acute inferior wall myocardial infarction. Thus the body surface map may be useful in assessing reperfusion by thrombolytic agents in acute myocardial infarction. In acute anterior wall myocardial infarction the body surface map was diagnostic but only moderately predictive of the eventual outcome. Again the area of ST segment elevation matched the area of Q wave formation and thus the body surface map may be of value in assessing reperfusion. The body surface mapping was unable to differentiate patients with and without coronary artery disease who had normal standard electrocardiograms. The body surface map was useful in differentiating patients with acute or old myocardial infarction from normal patients but did not detect coronary artery disease in the absence of myocardial damage. The information content of the body surface is increased if an accurate inverse transformation can be used to calculate the epicardial potentials in the clinical situation. To prove that epicardial potentials are accurately calculated, comparison of the area of myocardial damage to the calculated epicardial area of ST segment elevation was made using thallium scanning. This demonstrated a good correlation demonstrating that the inverse transformation was accurate. The technique is adding a new dimension to the understanding of the origin of the electrocardiogram. Body surface mapping is an easily performed clinical investigation that adds information in the assessment of the patients with myocardial infarction.
Active Galactic Nuclei with Starbursts: Sources for Ultra High Energy Cosmic Rays
Creators: name: Biermann, P. L.
name: Becker, J. K.
name: Caramete, L.
name: Gergely, L. A.
name: Maris, I. C.
name: Meli, A.
name: de Souza, V.
name: Stanev, T.
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Ultra high energy cosmic ray events presently show a spectrum, which we interpret here as galactic cosmic rays due to a starburst in the radio galaxy Cen A pushed up in energy by the shock of a relativistic jet. The knee feature and the particles with energy immediately higher in galactic cosmic rays then turn into the bulk of ultra high energy cosmic rays. This entails that all ultra high energy cosmic rays are heavy nuclei. This picture is viable if the majority of the observed ultra high energy events come from the radio galaxy Cen A, and are scattered by intergalactic magnetic fields across most of the sky.
description: 4 pages, 1 figure, proceedings of "High-Energy Gamma-rays and Neutrinos from Extra-Galactic Sources", Heidelberg
Design, synthesis, anticancer evaluation, in silico docking and ADMET analysis of novel indole-based thalidomide analogs as promising immunomodulatory agents
Creators: name: El-Zahabi, Mohamed Ayman
name: Elkady, Hazem
name: Sakr, Helmy
name: Abdelraheem, Adel S.
name: Eissa, Sally I.
name: El-Adl, Khaled.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health

description: In the present work, novel 16 indole-based thalidomide analogs were designed and synthesized to obtain new effective antitumor immunomodulatory agents. The synthesized compounds were evaluated for their cytotoxic activities against HepG-2, HCT-116, PC3 and MCF-7 cell lines. Generally, the opened analogs of glutarimide ring exhibited higher activities than the closed ones. Compounds 21a–b and 11d,g showed strong potencies against all tested cell lines with IC50 values ranging from 8.27 to 25.20 µM comparable to that of thalidomide (IC50 values ranging from 32.12 to 76.91 µM). The most active compounds were further evaluated for their in vitro immunomodulatory activities via estimation of human tumor necrosis factor alpha (TNF-α), human caspase-8 (CASP8), human vascular endothelial growth factor (VEGF), and nuclear factor kappa-B P65 (NF-κB P65) in HCT-116 cells. Thalidomide was used as a positive control. Compounds 11g, 21a and 21b showed remarkable significant reduction in TNF-α. Furthermore, compounds 11g, 21a and 21b showed significant elevation in CASP8 levels. Compounds 11g and 21a significantly inhibited VEGF. In addition, derivatives 11d, 11g and 21a showed significant decrease in level of NF-κB p65. Moreover, our derivatives exhibited good in silico docking and ADMET profile. Communicated by Ramaswamy H. Sarma
Using adiabatic coupling techniques in atom-chip waveguide structures
Creators: name: O'Sullivan, B.
name: Morrissey, P.
name: Morgan, T.
name: Busch, Th.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: Adiabatic techniques are well known tools in multi-level electron systems to transfer population between different states with high fidelity. Recently it has been realised that these ideas can also be used in ultra-cold atom systems to achieve coherent manipulation of the atomic centre-of-mass states. Here we present an investigation into a realistic setup using three atomic waveguides created on top of an atom chip and show that such systems hold large potential for the observation of adiabatic phenomena in experiments.
description: 10 pages, 6 figures, accepted for publication in Physica Scripta for the CEWQO2009 proceedings
Formation Criteria and the Mass of Secondary Population III Stars
Creators: name: Susa, Hajime
name: Umemura, Masayuki
name: Hasegawa, Kenji
Publisher: name: arXiv
Year: 2009
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We explore the formation of secondary Population III (Pop III) stars under radiation hydrodynamic (RHD) feedback by a preformed massive star. To properly treat RHD feedback, we perform three-dimensional RHD simulations incorporating the radiative transfer of ionizing photons as well as H_2 dissociating photons from a preformed star. A collapsing gas cloud is settled at a given distance from a 120Msun Pop III star, and the evolution of the cloud is pursued including RHD feedback. We derive the threshold density depending on the distance, above which the cloud can keep collapsing owing to the shielding of H_2 dissociating radiation. We find that an H_2 shell formed ahead of an ionizing front works effectively to shield the H_2 dissociating radiation, leading to the positive feedback for the secondary Pop III star formation. Also, near the threshold density, the envelope of gas cloud is stripped significantly by a shock associated with an ionizing front. By comparing the mass accretion timescale with the Kelvin-Helmholtz timescale, we estimate the mass of secondary Pop III stars. It turns out that the stripping by a shock can reduce the mass of secondary Pop III stars down to \approx 20Msum.
description: ApJ accepted, 11 pages, 11 figures
Magnesium regulation in Aedes campestris larvae
Creators: name: Kiceniuk, Joe Willie
Publisher: name: University of British Columbia
Year: 2011

description: Regulation of hemolymph and whole-body Mg ++ concentration was studied in the larvae of Aedes campestris Dyar and Knab from a salt-lake containing 190 m Eq Mg++/litre. Hemolymph Mg++ concentration of the larvae responded quickly to a change in external Mg++ concentration and reached a new level after one day. Over a wide range (0.02 to 200 m Eq/litre) of external Mg++ concentrations the blood Mg++ concentration changed only from 4 to 8 m Eq/litre. The rate of entry of Mg++ into the larvae by drinking was 19 to 57 n Eq/mg x hr. Drinking rate was found to be independent of temperature (10C- 22C), Mg++ concentration (100- 300 m Eq/litre), and presence of particles in the medium. More than 95% of the ingested Mg++ was absorbed from the midgut. Whole-body Mg++ content of larvae remained low, indicating that excess Mg++ was not stored in tissue. Measurement of urine Mg++ concentrations of animals in different media showed that excretion via urine could account for all of the ingested Mg++. Anal papillae need not therefore be implicated in Mg++ excretion in Aedes campestris larvae.
The application of Rousseau's theory of social contract to corporate governance
Creators: name: Baron, PD
Publisher: name: University Of Tasmania
Year: 2023

description: Much of the literature in the area of Australian corporate law reveals dissatisfaction with our current regulatory scheme. Despite extensive (and ongoing) legislative reforms, the scheme continues to be criticised as costly, complex and largely inefficient in regulating corporate abuse. The objective of this thesis is to consider a new model of corporate governance, both internal (that is, between the members and the management of the corporation) and external (that is, between the corporation and the state). This model is based upon the theory of contractual rights and obligations proposed by Jean Jacques Rousseau in The Social Contract. The value of this model is that it recognises and seeks to reconcile the inherent tension which underlies all associations (be they family, state or corporation): that of individual self-interest on the one hand and the collective good on the other. In this thesis, I shall argue that our ideas of what a corporation is and how it should be governed have been largely constructed by liberal theory. The corporation and its regulation, then, are not absolutes, but social and historical constructs which we are free to reject or modify as we see fit. By examining the ways in which the values and assumptions of liberalism are made explicit in corporate law; then by comparing the traditional model of corporate law with that based upon Rousseau's social contract theory, I shall seek to show that many of the assumptions and values underlying corporate law are no longer valid. Merely 'patching up' the existing model is insufficient. What is needed is a complete re-evaluation of the corporation and its place in our society. The thesis will begin by examining the corporation as a political entity. Rousseau's political theory will then be contrasted with those of Hobbes and Locke in order to reveal the different values and assumptions that underlie these theories. I shall then examine the way in which contemporary company law is based upon the values and assumptions of liberalism, before examining both the internal and external governance of corporations in order to identify the problems of regulation and the application of Rousseau's theory to those problems.
Virtual screening and structure–activity relationship study of novel BTK inhibitors in Traditional Chinese Medicine for the treatment of rheumatoid arthritis
Creators: name: Sun, Lili
name: Wang, Zixiao
name: Yang, Zhigang
name: Liu, XiuJuan
name: Dong, Haiyan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Bruton tyrosine kinase (BTK) is a known drug target for the treatment of autoimmune diseases, including rheumatoid arthritis (RA). In this study, a series of 1-amino-1H-imidazole-5-carboxamide derivatives with good inhibitory activity against BTK were selected to explore the structure-activity relationships of these BTK inhibitors (BTKIs). Furthermore, we concentrated on 182 prescriptions of Traditional Chinese Medicine with therapeutic effects on RA. 54 herbs with a frequency of ≥10 were counted to establish a database containing 4027 ingredients for virtual screening. Five compounds with relatively higher docking scores and better absorption, distribution, metabolism, elimination and toxicity (ADMET) parameters were then selected for higher precision docking. The results demonstrated that the potentially active molecules form hydrogen bond interactions with the hinge region residues Met477, Glu475, glycine-rich P-loop residue Val416, Lys430 and DFG motif Asp539. In particular, they also interact with the key residues Thr474 and Cys481 of BTK. The molecular dynamics (MD) results demonstrated that all five compounds above could bind with BTK stably as its cognate ligand in dynamic conditions. This work identified several potential BTKIs using a computer-aided drug design approach and may provide crucial information for developing novel BTKIs. Communicated by Ramaswamy H. Sarma
The pathogenesis and behaviour of clinical endocrinopathy in multiple endocrine neoplasia type 1
Creators: name: Burgess, John Richard
Publisher: name: University Of Tasmania
Year: 2023

description: As a first year medical student at the University of Tasmania in 1984, I learned of the rare autosomal dominant disease - multiple endocrine neoplasia type 1 (MEN 1), then newly recognised to be at high prevalence in the island state of Tasmania. MEN 1 had been reported to be an \all or none\" syndrome characterised by the triad of parathyroid hyperplasia pancreatic neoplasia and pituitary tumour. As an intern undertaking a term on the professorial surgical unit I was struck by the diversity of MEN 1 phenotypic disease. Whilst some patients survived to advanced age with minimal clinical disease others developed aggressive polyendocrinopathy early in life. Some four years later in 1994 as an advanced trainee in endocrinology at the Royal Hobart Hospital I was again surprised by aspects of disease expression in this disorder. In some families specific disease manifestations appeared to be particularly common whilst rare in others. The research presented in this thesis was undertaken by myself between 1995 and 1998 in an attempt to establish the extent and aetiology of phenotypic variability in MEN 1 disease expression. My role in this work spans all aspects of the research - conceptual planning submission of applications for funding and institutional ethics committee approval patient recruitment clinical screening collection and collation of biomedical data statistical analysis and preparation of manuscripts for publication. In conjunction with this research I have established the Tasmanian MEN 1 Register. AIMS 1. To assess the extent and significance of disease homogeneity and heterogeneity in families with MEN 1. 2. To determine if a role exists for heritable disease modifier factor(s) in the pathogenesis of disease associated with MEN 1. 3. To identify factors influencing the clinical behaviour and response to treatment of endocrine disease associated with MEN 1. HYPOTHESIS Whilst a mutation of the MEN 1 gene is central to the pathogenesis of disease in MEN 1 disease modifier factors have an important role in determining the development and clinical behaviour of MEN 1 disease phenotypes."
Phase transitions in the $sdg$ interacting boson model
Creators: name: Van Isacker, P.
name: Bouldjedri, A.
name: Zerguine, S.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: A geometric analysis of the $sdg$ interacting boson model is performed. A coherent-state is used in terms of three types of deformation: axial quadrupole ($β_2$), axial hexadecapole ($β_4$) and triaxial ($γ_2$). The phase-transitional structure is established for a schematic $sdg$ hamiltonian which is intermediate between four dynamical symmetries of U(15), namely the spherical ${\rm U}(5)\otimes{\rm U}(9)$, the (prolate and oblate) deformed ${\rm SU}_\pm(3)$ and the $γ_2$-soft SO(15) limits. For realistic choices of the hamiltonian parameters the resulting phase diagram has properties close to what is obtained in the $sd$ version of the model and, in particular, no transition towards a stable triaxial shape is found.
description: 19 pages, 5 figures, submitted to J. Phys. G
Novel multi-epitope vaccine against bovine brucellosis: approach from immunoinformatics to expression
Creators: name: Rahimnahal, Somayyeh
name: Yousefizadeh, Shahnaz
name: Mohammadi, Yahya
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Brucellosis is a zoonotic caused by the Brucella which is a well-known infectious disease agent in domestic animals and if transmitted, it can cause infection in humans. Because brucellosis is contagious, its control depends on the eradication of the animal disease in farms. There are two vaccines based on the killed and/or weakened bacteria against B. melitensis and B. abortus, but no recombinant vaccine is available for preventing the disease. The present study was designed to develop a multi-epitope vaccine against of B. melitensis and B. abortus using virB10, Omp31 and Omp16 antigens by the prediction of T lymphocytes, T cell cytotoxicity and IFN-γ epitopes. 50S L7/L12 Ribosomal protein from Mycobacterium tuberculosis was used as a bovine TLR4 and TLR9 agonist. GPGPG, AAY and KK linkers were used as a linker. Brucella construct was well-integrated in the pET-32a Shuttle vector with BamHI and HindIII restriction enzymes. The final construct contained 769 amino acids, that it was soluble protein of about ∼82 kDa after expression in the Escherichia coli SHuffle host. Modeled protein analysis based on the tertiary structure validation, molecular docking studies, molecular dynamics simulations results like RMSD, Gyration and RMSF as well as MM/PBSA analysis showed that this protein has a stable construct and is capable being in interaction with bovine TLR4 and TLR9. Analysis of the data obtained suggests that the proposed vaccine can induce the immune response by stimulating T- and B-cells, and may be used for prevention and remedial purposes, against B. melitensis and B. abortus. Communicated by Ramaswamy H. Sarma
Binding order and apparent binding affinity in the bisubstrate activity of strictosidine synthase
Creators: name: Kulhar, Nitin
name: Rajakumara, Eerappa
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: The Rauvolfia serpentina strictosidine synthase (RsSTR) enzyme with a bisubstrate activity is central to monoterpenoid indole alkaloid (MIA) biosynthesis pathways, as it stereoselectively condenses the terpenoid and indole metabolites, secologanin and tryptamine, respectively, into strictosidine. Here, cooperativity was aimed to be deciphered by proxy with help of a non-substrate tryptamine analog (decoy compound) to allow a bisubstrate binding without reaction, facilitating an isothermal titration calorimetry (ITC)-based analysis of the effect of the presence of one substrate on the binding of the other. Tryptamine and tryptamine analog bound to RsSTR with similar binding affinities (Kd). On the contrary, ITC revealed an exothermic titration of secologanin to RsSTR but could not fully quantify it because of weak binding. Interestingly, secologanin bound to RsSTR with an apparent binding affinity (Kd,app) of 212.1 μM in the presence of the decoy compound, as opposed to a lack of binding to RsSTR alone, strongly suggesting a “tryptamine-first” mode of binding. Conversely, binding of tryptamine analog in the presence of secologanin was enhanced >3-fold. Further, molecular dynamics simulation (MDS) analyses revealed the conformational flexibility needed for such cooperativity. Our binding studies complemented with the computational analyses suggested cooperativity in the ordered bisubstrate binding to RsSTR. Therefore, understanding thermodynamics and cooperativity in the binding of substrates or ligands would help to unravel the mechanism of enzyme catalysis and ligand-receptor interactions, and would guide the redesign of enzymes for enhanced properties and the design of inhibitors against enzymes and receptors. Communicated by Ramaswamy H. Sarma