cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Driven Markovian Quantum Criticality
Creators: name: Marino, Jamir
name: Diehl, Sebastian
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We identify a new universality class in one-dimensional driven open quantum systems with a dark state. Salient features are the persistence of both the microscopic non-equilibrium conditions as well as the quantum coherence of dynamics close to criticality. This provides a non-equilibrium analogue of quantum criticality, and is sharply distinct from more generic driven systems, where both effective thermalization as well as asymptotic decoherence ensue, paralleling classical dynamical criticality. We quantify universality by computing the full set of independent critical exponents within a functional renormalization group approach.
description: 5+3 pages, 2 figures; published version with improved presentation of results
Identification of Atlantic Chub mackerel Scomber colias population through the analysis of body shape in Tunisian waters
Creators: name: ALLAYA, Hassen
name: BEN FALEH, Abderraouf
name: REBAYA, Manel
name: ZRELLI, Sonia
name: HAJJEJ, Ghailen
name: HATTOUR, Abdallah
name: QUIGNARD, Jean-Pierre
name: TRABELSI, Monia
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2016

description: The Atlantic chub mackerel Scomber colias (Gmelin, 1789) is one of the main fisheries resources in Tunisian waters. Studying the differentiation of populations of this species presents a great importance in the resource management and knowledge of environment diversity. Therefore, morphological characteristics from three distant sampling sites along the coast of Tunisia were analysed, using 13 morphometric and 4 meristic characters in order to investigate the morphological variation of these species. Analysis of variance (ANOVA) of 314 adult specimens showed significant differences for 13 standardized morphometric measurements and 2 meristic characters (the number of branchial spins Right (BrR) and Left (BrL)) for the three landing sites using Sheffe's post-Hoc test. In morphometric traits, discriminant function analysis (DFA), the scatter plot of individual component score between DF1 and DF2 showed that all specimens assigned into 3 morphometric groups that correspond to the three landing sites. For the meristic characters, a scatter plot of DFA clearly showed a distinction between Mahdia population, Ghar El Melh and that of Zarzis. In this analysis, the overall assignments of individuals into their origin groups were 83.87% for the morphometric variables and 49% for the meristic data, respectively. The current study indicated that Atlantic chub mackerel landing sites surveyed had high morphologically differentiation between the three sampling sites along the coast of Tunisia which could be caused by differences in genetic structure or environmental parameters.
Large-scale statistical analysis and modelling of real and regulatory total energy use in existing single-family houses in Flanders
Creators: name: Van Hove, M. Y. C.
name: Deurinck, M.
name: Lameire, W.
name: Laverge, J.
name: Janssens, A.
name: Delghust, M.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Large-scale statistical studies on the gap between the real and regulatory energy use in residential buildings in Europe have shown that the regulatory calculation overestimated the real energy use, inflated true energy savings and undermined national energy policy making. Using data from 122,680 Flemish existing single-family houses, this research builds further on existing studies by contributing results for Flanders. The study also examines to what extent available aggregated variables explain the real annual total building energy use using statistical linear models and addresses the problem of multicollinearity and the importance of bootstrapped confidence intervals for model quality control. The overestimation of the real total energy use (and potential energy savings) by the Flemish regulatory method is exceedingly large compared to studies from other EU countries. The Flemish labels prove very poor indicators of the real energy use. Statistical linear models explain up to 46.6% of all variability and indicate that a significant extent of multicollinearity had to be corrected. Half of the variability has been left unexplained and has to be attributed to variables that were not available and the fact that the data were insufficiently accurate. Future analysis will explore whether more complex models identify more evidence.
Additional file 1 of Challenges to the right to health in sub-Saharan Africa: reflections on inequities in access to dialysis for patients with end-stage kidney failure
Creators: name: Ashu, James Tataw
name: Mwangi, Jackline
name: Subramani, Supriya
name: Kaseje, Daniel
name: Ashuntantang, Gloria
name: Luyckx, Valerie A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1.
title: Radiation therapy in the management of early Dupuytren’s contracture – revisiting the discussion
Creators: name: Baxi, Siddhartha
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Treatment effects
subject: Radiation therapy / Oncology
subject: Efficacy studies
subject: Ultrasound
subject: Extremities
subject: Soft tissues / Skin
subject: Connective tissue disorders
subject: Radiotherapy techniques
subject: Patterns of Care

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Radiation therapy can halt the progression of early Dupuytren’s contracture in appropriately selected patients.Overseas data indicates either symptomatic improvement or stabilised disease in approximately 80% of cases.[1] In an era of historically...
Comparative Evaluation of Symmetric SVD Algorithms for Real-time Face and Eye Tracking
Creators: name: Pradhan, Tapan
name: Routray, Aurobinda
name: Kabi, Bibek
Publisher: name: arXiv
Year: 2015
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: Computation of singular value decomposition (SVD) has been a topic of concern by many numerical linear algebra researchers. Fast SVD has been a very effective tool in computer vision in a number of aspects, such as: face recognition, eye tracking etc. At the present state of the art fast and fixed-point power efficient SVD algorithm needs to be developed for real-time embedded computing. The work in this paper is the genesis of an attempt to build an on-board real-time face and eye tracking system for human drivers to detect loss of attention due to drowsiness or fatigue. A major function of this on-board system is quick customization. This is carried out when a new driver comes in. The face and eye images are recorded while instructing the driver for making specific poses. The eigen faces and eigen eyes are generated at several resolution levels and stored in the on-board computer. The discriminating eigen space of face and eyes are determined and stored in the on-board flash memory for detection and tracking of face and eyes and classification of eyes (open or closed) as well. Therefore, fast SVD of image covariance matrix at various levels of resolution needs to be carried out to generate the eigen database. As a preliminary step, we review the existing symmetric SVD algorithms and evaluate their feasibility for such an application. In this article, we compare the performance of (1) Jacobi's, (2) Hestenes', (3) Golub-Kahan, (4) Tridiagonalization and Symmetric QR iteration and (5) Tridiagonalization and Divide and Conquer algorithms. A case study has been demonstrated as an example.
description: 20 pages, 4 figures, book chapter
The digestive system of Euphausia krohni (Crustacea, Euphausiacea): functional morphology and phylogenetic relevance
Creators: name: JONG, Laetitia De
name: JEAN, Séverine
name: MOREAU, Xavier
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2004

description: This report deals with the structure and ultrastructure of the labrum, foregut, midgut and midgut gland of
 Euphausia krohni. The labrum appears to play a major role in the first step of the digestive process. It is involved in both
 mechanical and chemical breakdown of the food. Structural, ultrastructural and cytochemical data on the labrum reveal
 similarities with the labrum of the primitive Mysidacea Lophogaster typicus (Lophogastrida). The foregut acts
 predominantly in triturating the food and in separating fine particles and fluids from coarse material by filters.
 Morphological features indicate that the foregut of euphausiids might have evolved from the same ancestral morphological
 type as the mysidaceans, i.e. close to Gnathophausia gracilis (Lophogastrida). The midgut exhibits typical ultrastructural
 features known in the Malacostraca, i.e. an epithelium composed of a single cell type which is implicated in absorption and
 production of peritrophic membranes. The midgut gland exhibits F-cells, considered to secrete enzymes in Decapoda, and
 not truly evidenced in the Mysidacea. Therefore, this study suggests that the digestive system of Euphausiacea has both
 primitive features evidenced in the lower Malacostraca (Lophogastrida), and also evolved ones found in the higher
 Malacostraca (Decapoda).
Mathematical Model of Nucleotide Regulation on Airway Epithelia: IMPLICATIONS FOR AIRWAY HOMEOSTASIS
Creators: name: Okada, Seiko F.
name: Elston, Timothy C.
name: Zuo, Peiying
name: Boucher, Richard C.
name: Picher, Maryse
name: Button, Brian
name: Lazarowski, Eduardo R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: In the airways, adenine nucleotides support a complex signaling network mediating host defenses. Released by the epithelium into the airway surface liquid (ASL) layer, they regulate mucus clearance through P2 (ATP) receptors, and following surface metabolism through P1 (adenosine; Ado) receptors. The complexity of ASL nucleotide regulation provides an ideal subject for biochemical network modeling. A mathematical model was developed to integrate nucleotide release, the ectoenzymes supporting the dephosphorylation of ATP into Ado, Ado deamination into inosine (Ino), and nucleoside uptake. The model also includes ecto-adenylate kinase activity and feed-forward inhibition of Ado production by ATP and ADP. The parameters were optimized by fitting the model to experimental data for the steady-state and transient concentration profiles generated by adding ATP to polarized primary cultures of human bronchial epithelial (HBE) cells. The model captures major aspects of ATP and Ado regulation, including their >4-fold increase in concentration induced by mechanical stress mimicking normal breathing. The model also confirmed the independence of steady-state nucleotide concentrations on the ASL volume, an important regulator of airway clearance. An interactive approach between simulations and assays revealed that feed-forward inhibition is mediated by selective inhibition of ecto-5′-nucleotidase. Importantly, the model identifies ecto-adenylate kinase as a key regulator of ASL ATP and proposes novel strategies for the treatment of airway diseases characterized by impaired nucleotide-mediated clearance. These new insights into the biochemical processes supporting ASL nucleotide regulation illustrate the potential of this mathematical model for fundamental and clinical research.
Polychaete assemblages of rocky shore along the South Adriaticcoast (Mediterranean Sea)
Creators: name: GIANGRANDE, Adriana
name: DELOS, Anna Lucia
name: MUSCO, Luigi
name: LICCIANO, Margherita
name: PIERRI, Cataldo
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2004

description: The present study deals with the distribution of hard substratum polychaete assemblages under different
 environmental conditions. Samples were collected along a stretch of coast from Torre Guaceto to Otranto (Southern Adriatic
 Sea, Italy), in three transects perpendicular to the coast from 5 to 25 m in July 2000, by scraping off 400 cm2. A total of
 3188 specimens, belonging to 118 taxa were collected. Multivariate analysis showed that polychaete assemblages differed
 among depths with a clear difference between the shallowest sites (5 m) and the deeper ones (15-25 m). A variation among
 sites was also observed, with highest differences among sites within samples collected at 5 m depth, and with a sharp
 separation of some samples relative to Torre Guaceto from the remaining ones. Some potential causes for the observed
 differences both within and among sites were hypothesized and discussed, as well as the usefulness of polychaete
 assemblage analysis as descriptor of different environmental situations.
PSAMMOLITTORAL MARINE TARDIGRADES FROM NORTH CAROLINA AND THEIR CONFORMITY TO WORLDWIDE ZONATION PATTERNS
Creators: name: LINDGREN, Eric W.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1971

description: Five species of tardigrades, Batillipes mirus, B. bullacaudatus, Stygarctus bradgpus, S. granulatus, and Tanarctus arbospinosus nov. spec., are reported from the ocean-exposed intertidal zone of Bogue Bank, North Carolina. The new species is distinguished by a dorsal median cirrus and extremely long posterio-lateral spines with several secondary branches and many smaller tertiary projections. Intertidal distributions for each species are discussed and correlated with ecological measurements.
Mechanism of MutS Searching for DNA Mismatches and Signaling Repair
Creators: name: Yang, Yong
name: Zhai, Jie
name: Hsieh, Peggy
name: Du, Chungwei
name: Hingorani, Manju M.
name: Tessmer, Ingrid
name: Erie, Dorothy A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: DNA mismatch repair is initiated by the recognition of mismatches by MutS proteins. The mechanism by which MutS searches for and recognizes mismatches and subsequently signals repair remains poorly understood. We used single-molecule analyses of atomic force microscopy images of MutS-DNA complexes, coupled with biochemical assays, to determine the distributions of conformational states, the DNA binding affinities, and the ATPase activities of wild type and two mutants of MutS, with alanine substitutions in the conserved Phe-Xaa-Glu mismatch recognition motif. We find that on homoduplex DNA, the conserved Glu, but not the Phe, facilitates MutS-induced DNA bending, whereas at mismatches, both Phe and Glu promote the formation of an unbent conformation. The data reveal an unusual role for the Phe residue in that it promotes the unbending, not bending, of DNA at mismatch sites. In addition, formation of the specific unbent MutS-DNA conformation at mismatches appears to be required for the inhibition of ATP hydrolysis by MutS that signals initiation of repair. These results provide a structural explanation for the mechanism by which MutS searches for and recognizes mismatches and for the observed phenotypes of mutants with substitutions in the Phe-Xaa-Glu motif.
Bradyagaue from Western Australia, description of a new species (Acari, Halacaridae)
Creators: name: BARTSCH, Ilse
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2004

description: Bradyagaue exilis sp. nov., from southwestern Australia, is described. This is the second Bradyagaue species
 from Western Australia.
title: Age and gender dependant variations of normal temporal lobe dimensions in the South Asian Population
Creators: name: Pallewatte, Aruna
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Neuroradiology brain
subject: MR
subject: Diagnostic procedure
subject: Dementia
subject: Geriatrics

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Medial temporal lobe structures such as hippocampus, parahippocampal and entorhinal neocortical regions are critical for declarative or long-term memory. It is well known that certain dementias are associated with atrophy and degeneration of these...
Multiple Membrane-Cytoplasmic Domain Contacts in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mediate Regulation of Channel Gating
Creators: name: Cui, Liying
name: Hegedus, Tamás
name: Aleksandrov, Andrei A.
name: Aleksandrov, Luba A.
name: Serohijos, Adrian W.R.
name: Dokholyan, Nikolay V.
name: He, Lihua
name: Riordan, John R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The cystic fibrosis transmembrane conductance regulator (CFTR) is a unique ATP-binding cassette (ABC) ion channel mutated in patients with cystic fibrosis. The most common mutation, deletion of phenylalanine 508 (ΔF508) and many other disease-associated mutations occur in the nucleotide binding domains (NBD) and the cytoplasmic loops (CL) of the membrane-spanning domains (MSD). A recently constructed computational model of the CFTR three-dimensional structure, supported by experimental data (Serohijos, A. W., Hegedus, T., Aleksandrov, A. A., He, L., Cui, L., Dokholyan, N. V., and Riordan, J. R. (2008) Proc. Natl. Acad. Sci. U. S. A. 105, 3256–3261) revealed that several of these mutations including ΔF508 disrupted interfaces between these domains. Here we have used cysteine cross-linking experiments to verify all NBD/CL interfaces predicted by the structural model and observed that their cross-linking has a variety of different effects on channel gating. The interdomain contacts comprise aromatic clusters important for stabilization of the interfaces and also involve the Q-loops and X-loops that are in close proximity to the ATP binding sites. Cross-linking of all domain-swapping contacts between NBDs and MSD cytoplasmic loops in opposite halves of the protein rapidly and reversibly arrest single channel gating while those in the same halves have lesser impact. These results reinforce the idea that mediation of regulatory signals between cytoplasmic- and membrane-integrated domains of the CFTR channel apparently relies on an array of precise but highly dynamic interdomain structural joints.
(4046) Janet Gilmour
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Partial Rescue of the Amelogenin Null Dental Enamel Phenotype
Creators: name: Harrison, Gerald
name: Simmons, Darrin
name: Daly, Bill
name: Fong, Hanson
name: Yuan, Zhi An
name: Aragon, Melissa
name: Li, Yong
name: Suggs, Cynthia
name: Golub, Ellis E.
name: Kulkarni, Ashok B.
name: Wright, J. Timothy
name: Gibson, Carolyn W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The amelogenins are the most abundant secreted proteins in developing dental enamel. Enamel from amelogenin (Amelx) null mice is hypoplastic and disorganized, similar to that observed in X-linked forms of the human enamel defect amelogenesis imperfecta resulting from amelogenin gene mutations. Both transgenic strains that express the most abundant amelogenin (TgM180) have relatively normal enamel, but strains of mice that express a mutated amelogenin (TgP70T), which leads to amelogenesis imperfecta in humans, have heterogeneous enamel structures. When Amelx null (KO) mice were mated with transgenic mice that produce M180 (TgM180), the resultant TgM180KO offspring showed evidence of rescue in enamel thickness, mineral density, and volume in molar teeth. Rescue was not observed in the molars from the TgP70TKO mice. It was concluded that a single amelogenin protein was able to significantly rescue the KO phenotype and that one amino acid change abrogated this function during development.
First occurrence of dusky grouper Epinephelus marginatus (Lowe, 1834) in a Marine Protected Area on the Uruguayan coast
Creators: name: CONDINI, Mario Vinicius
name: VÉLEZ-RUBIO, Gabriela M.
name: FALLABRINO, Alejandro
name: GARCIA, Alexandre Miranda
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2016

description: The present study reports the first records of endangered species, dusky grouper Epinephelus marginatus, on the Uruguayan coast. The occurrence of dead or disoriented individuals along the surf zone within the Marine Protected Area (MPA) of Cerro Verde (Uruguay) was recorded. Continuous monitoring and future studies are needed to reveal the relevance of this MPA in the conservation of this endangered grouper species in the southernmost limit of its distribution in the Southwestern Atlantic.
Preferential Assembly of Epithelial Sodium Channel (ENaC) Subunits in Xenopus Oocytes: ROLE OF FURIN-MEDIATED ENDOGENOUS PROTEOLYSIS
Creators: name: Harris, Michael
name: Stutts, M. Jackson
name: Rossier, Bernard C.
name: Firsov, Dmitri
name: Garcia-Caballero, Agustin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The epithelial sodium channel (ENaC) is preferentially assembled into heteromeric αβγ complexes. The α and γ (not β) subunits undergo proteolytic cleavage by endogenous furin-like activity correlating with increased ENaC function. We identified full-length subunits and their fragments at the cell surface, as well as in the intracellular pool, for all homo- and heteromeric combinations (α, β, γ, αβ, αγ, βγ, and αβγ). We assayed corresponding channel function as amiloride-sensitive sodium transport (INa). We varied furin-mediated proteolysis by mutating the P1 site in α and/or γ subunit furin consensus cleavage sites (αmut and γmut). Our findings were as follows. (i) The β subunit alone is not transported to the cell surface nor cleaved upon assembly with the α and/or γ subunits. (ii) The α subunit alone (or in combination with β and/or γ) is efficiently transported to the cell surface; a surface-expressed 65-kDa α ENaC fragment is undetected in αmutβγ, and INa is decreased by 60%. (iii) The γ subunit alone does not appear at the cell surface; γ co-expressed with α reaches the surface but is not detectably cleaved; and γ in αβγ complexes appears mainly as a 76-kDa species in the surface pool. Although basal INa of αβγmut was similar to αβγ, γmut was not detectably cleaved at the cell surface. Thus, furin-mediated cleavage is not essential for participation of α and γ in αβγ heteromers. Basal INa is reduced by preventing furin-mediated cleavage of the α, but not γ, subunits. Residual current in the absence of furin-mediated proteolysis may be due to non-furin endogenous proteases.
Three new species of Tisbe (Copepoda: Harpacticoida) and a new record with complete redescription of Tisbe monozota from north-western Mexico
Creators: name: GÓMEZ, Samuel
name: PUELLO-CRUZ, Ana Carmela
name: GONZÁLEZ-RODRÍGUEZ, Blanca
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2004

description: Representatives of the genus Tisbe were collected during two short-term studies examining the effects of organic
 enrichment on the abundance of meiofauna and diversity of harpacticoid copepods in two coastal systems in central and
 southern Sinaloa (north-western Mexico), and from an experimental culture of bullseye puffer (Sphoeroides annulatus).
 Three new species are described: Tisbe antennulodenticulata sp. nov., T. brigittevolkmannae sp. nov. and T. puelloi sp. nov..
 Additionally T. longisetosa is relegated to a species inquirenda. Some specimens collected from experimental cultures of
 bullseye puffer turned out to belong to T. monozota known from a salt water aquarium in Florida. To the best of our
 knowledge, this is the first time that T. monozota is reported from the Tropical Eastern Pacific, and it is the second report of
 the species from salt water aquariums. A complete redescription of the species is provided.
Translation Memory Retrieval Methods
Creators: name: Bloodgood, Michael
name: Strauss, Benjamin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences
subject: I.2.7

description: Translation Memory (TM) systems are one of the most widely used translation technologies. An important part of TM systems is the matching algorithm that determines what translations get retrieved from the bank of available translations to assist the human translator. Although detailed accounts of the matching algorithms used in commercial systems can't be found in the literature, it is widely believed that edit distance algorithms are used. This paper investigates and evaluates the use of several matching algorithms, including the edit distance algorithm that is believed to be at the heart of most modern commercial TM systems. This paper presents results showing how well various matching algorithms correlate with human judgments of helpfulness (collected via crowdsourcing with Amazon's Mechanical Turk). A new algorithm based on weighted n-gram precision that can be adjusted for translator length preferences consistently returns translations judged to be most helpful by translators for multiple domains and language pairs.
description: 9 pages, 6 tables, 3 figures; appeared in Proceedings of the 14th Conference of the European Chapter of the Association for Computational Linguistics, April 2014
Rho Family GTPase Modification and Dependence on C AAX Motif-signaled Posttranslational Modification
Creators: name: Der, Channing J.
name: Chenette, Emily J.
name: Kirschmeier, Paul
name: Wilson, Oswald
name: Mitin, Natalia
name: Keller, Patricia J.
name: Cox, Adrienne D.
name: Currin, Rachel O.
name: Roberts, Patrick J.
name: Madigan, James P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Rho GTPases (20 human members) comprise a major branch of the Ras superfamily of small GTPases, and aberrant Rho GTPase function has been implicated in oncogenesis and other human diseases. Although many of our current concepts of Rho GTPases are based on the three classical members (RhoA, Rac1, and Cdc42), recent studies have revealed the diversity of biological functions mediated by other family members. A key basis for the functional diversity of Rho GTPases is their association with distinct subcellular compartments, which is dictated in part by three posttranslational modifications signaled by their carboxyl-terminal CAAX (where C represents cysteine, A is an aliphatic amino acid, and X is a terminal amino acid) tetrapeptide motifs. CAAX motifs are substrates for the prenyltransferase-catalyzed addition of either farnesyl or geranylgeranyl isoprenoid lipids, Rce1-catalyzed endoproteolytic cleavage of the AAX amino acids, and Icmt-catalyzed carboxyl methylation of the isoprenylcysteine. We utilized pharmacologic, biochemical, and genetic approaches to determine the sequence requirements and roles of CAAX signal modifications in dictating the subcellular locations and functions of the Rho GTPase family. Although the classical Rho GTPases are modified by geranylgeranylation, we found that a majority of the other Rho GTPases are substrates for farnesyltransferase. We found that the membrane association and/or function of Rho GTPases are differentially dependent on Rce1- and Icmt-mediated modifications. Our results further delineate the sequence requirements for prenyltransferase specificity and functional roles for protein prenylation in Rho GTPase function. We conclude that a majority of Rho GTPases are targets for pharmacologic inhibitors of farnesyltransferase, Rce1, and Icmt.
APERÇU SUR LA BATHYMÉTRIE, LA SEDIMENTOLOGIE ET LES PEUPLEMENTS BENTHIÇUES DU LARGE DE ROSCOFF D'APRÈS LA CARTE BATHYMÉTRIÇUE AU I/40.000e ET LES PHOTOGRAPHIES SOUS-MARINES
Creators: name: AUFFRET, G.A.
name: BERTHOIS, L.
name: CABIOCH, L.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1971

description: A comparative study of echo-sounding profiles and underwater photographs taken along them brings precisions on the morphology, sedimentology and distribution of benthic populations. It is suggested that periglacial solifluction may have contributed to the deposition of the layers of stones and boulders on the paleozoic and eocene grounds off Roscoff.
Ribosomal Protein S9 Is a Novel B23/NPM-binding Protein Required for Normal Cell Proliferation
Creators: name: Zhang, Yanping
name: Lindström, Mikael S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: B23 (NPM/nucleophosmin) is a multifunctional nucleolar protein and a member of the nucleoplasmin superfamily of acidic histone chaperones. B23 is essential for normal embryonic development and plays an important role in genomic stability, ribosome biogenesis, and anti-apoptotic signaling. Altered protein expression or genomic mutation of B23 is encountered in many different forms of cancer. Although described as multifunctional, a genuine molecular function of B23 is not fully understood. Here we show that B23 is associated with a protein complex consisting of ribosomal proteins and ribosome-associated RNA helicases. A novel, RNA-independent interaction between ribosomal protein S9 (RPS9) and B23 was further investigated. We found that S9 binding requires an intact B23 oligomerization domain. Depletion of S9 by small interfering RNA resulted in decreased protein synthesis and G1 cell cycle arrest, in association with induction of p53 target genes. We determined that S9 is a short-lived protein in the absence of ribosome biogenesis, and proteasomal inhibition significantly increased S9 protein level. Overexpression of B23 facilitated nucleolar storage of S9, whereas knockdown of B23 led to diminished levels of nucleolar S9. Our results suggest that B23 selectively stores, and protects ribosomal protein S9 in nucleoli and therefore could facilitate ribosome biogenesis.
Selective Targeting of Leukemic Cell Growth in Vivo and in Vitro Using a Gene Silencing Approach to Diminish S -Adenosylmethionine Synthesis
Creators: name: Taxman, Debra J.
name: Geller, Arthur
name: Gardner, Lidia A.
name: Kotb, Malak
name: Mahrous, Engy
name: Ting, Jenny P.Y.
name: Rowe, Sarah
name: LeGros, Leighton
name: Attia, Ramy R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: We exploited the fact that leukemic cells utilize significantly higher levels of S-adenosylmethionine (SAMe) than normal lymphocytes and developed tools that selectively diminished their survival under physiologic conditions. Using RNA interference gene silencing technology, we modulated the kinetics of methionine adenosyltransferase-II (MAT-II), which catalyzes SAMe synthesis from ATP and l-Met. Specifically, we silenced the expression of the regulatory MAT-IIβ subunit in Jurkat cells and accordingly shifted the of the enzyme 10–15-fold above the physiologic levels of l-Met, thereby reducing enzyme activity and SAMe pools, inducing excessive apoptosis and diminishing leukemic cell growth in vitro and in vivo. These effects were reversed at unphysiologically high l-Met (>50 μm), indicating that diminished leukemic cell growth at physiologic l-Met levels was a direct result of the increase in MAT-II due to MAT-IIβ ablation and the consequent reduction in SAMe synthesis. In our NOD/Scid IL-2Rγnull humanized mouse model of leukemia, control shRNA-transduced Jurkat cells exhibited heightened engraftment, whereas cells lacking MAT-IIβ failed to engraft for up to 5 weeks post-transplant. These stark differences in malignant cell survival, effected by MAT-IIβ ablation, suggest that it may be possible to use this approach to disadvantage leukemic cell survival in vivo with little to no harm to normal cells.
(4042) Richard Poole
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: A review of imaging features, anatomical variations, prevalence and associated anomalies of oblique occipital sinus on Magnetic Resonance Venography (MRV)
Creators: name: Pallewatte, Aruna
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Diagnostic procedure
subject: MR-Angiography
subject: Neuroradiology brain
subject: Congenital

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: 1.Introduction to Oblique Occipital Sinus and related embryology. 2.MRV and other radiological techniques used to study cerebral venous drainage specially in the diagnosis of cerebral venous sinus thrombosis. 3.Anatomy of occipital...
Site-specific Androgen Receptor Serine Phosphorylation Linked to Epidermal Growth Factor-dependent Growth of Castration-recurrent Prostate Cancer
Creators: name: Wilson, Elizabeth M.
name: French, Frank S.
name: Gregory, Christopher W.
name: Ponguta, Liliana A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The androgen receptor (AR) is required for prostate cancer development and contributes to tumor progression after remission in response to androgen deprivation therapy. Epidermal growth factor (EGF) increases AR transcriptional activity at low levels of androgen in the CWR-R1 prostate cancer cell line derived from the castration-recurrent CWR22 prostate cancer xenograft. Here we report that knockdown of AR decreases EGF stimulation of prostate cancer cell growth and demonstrate a mechanistic link between EGF and AR signaling. The EGF-induced increase in AR transcriptional activity is dependent on phosphorylation at mitogen-activated protein kinase consensus site Ser-515 in the AR NH2-terminal region and at protein kinase C consensus site Ser-578 in the AR DNA binding domain. Phosphorylation at these sites alters the nuclear-cytoplasmic shuttling of AR and AR interaction with the Ku-70/80 regulatory subunits of DNA-dependent protein kinase. Abolishing AR Ser-578 phosphorylation by introducing an S578A mutation eliminates the AR transcriptional response to EGF and increases both AR binding of Ku-70/80 and nuclear retention of AR in association with hyperphosphorylation of AR Ser-515. The results support a model in which AR transcriptional activity increases castration-recurrent prostate cancer cell growth in response to EGF by site-specific serine phosphorylation that regulates nuclear-cytoplasmic shuttling through interactions with the Ku-70/80 regulatory complex.
Length-weight relationship and maturity of the Atlantic mackerel Scomber scombrus from the Adriatic Sea (Eastern Mediterranean)
Creators: name: BOTTARI, Teresa
name: RINELLI, Paola
name: GIORDANO, Daniela
name: GRECO, Silvestro
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2004

description: The Atlantic mackerel, Scomber scombrus, is widely distributed throughout the Mediterranean Sea. Most studies
 on S. scombrus have been realized from the Atlantic Sea and updated information about this species in the Mediterranean
 Sea is still poor. Data on S. scombrus sampled in the South Adriatic Sea have been analysed to elucidate seasonal and annual
 pattern of weight-length relationship and maturity of gonads. A total of 828 specimens were analysed from November 2000
 to October 2001. The Atlantic mackerel is confirmed as a winterspawner species. A negative allometry was established
 during the spawning period for total and gutted fish weight analysis, which recorded the same trend during the year.
 Otherwise the annual allometry coefficient "b" values showed, for both sexes, an isometric and an allometric (negative)
 growth for total and gutted fish weight respectively. No differences among sexes were observed.
Self-Adjointness and Domain of the Froehlich Hamiltonian
Creators: name: Griesemer, M.
name: Wuensch, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: 81Q10, 81T16

description: In the large polaron model of H. Froehlich, the electron-phonon interaction is a small perturbation in form sense, but a large perturbation in operator sense. This means that the form-domain of the Hamiltonian is not affected by the interaction but the domain of self-adjointness is. In the particular case of the Froehlich model, we are nevertheless able, thanks to a recently published new operator bound, to give an explicit characterization of the domain in terms of a suitable dressing transform. Using the mapping properties of this dressing transform, we analyze the smoothness of vectors in the domain of the Hamiltonian with respect to the position of the electron.
description: 20 pages, with some clarifications and improvements compared to version 1. To appear in Journal of Mathematical Physics
THE PRODUCTION OF THE GASTROPODS RISSOA-PARVA, BARLEEIA-UNIFASCIATA AND BITTIUM-RETICULATUM WAS CALCULATED IN 6 POPULATIONS INHABITING AT THE BASQUE COAST (N SPAIN)
Creators: name: Borja, A.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1988

Abstract
title: Whole body computed tomography versus selective imaging in patients with trauma.
Creators: name: Chacko, Amit
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Emergency
subject: Trauma
subject: CT
subject: Conventional radiography
subject: Audit and standards
subject: Diagnostic procedure
subject: Safety
subject: Trauma
subject: Quality assurance

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: To assess the benefit of patients involved in trauma who undergo whole body computed tomography (CT) compared to traditional selective imaging during their initial assessment. Patients who are considered for whole body CT are selected due to their...
Structural Determinants Underlying the Temperature-sensitive Nature of a Gα Mutant in Asymmetric Cell Division of Caenorhabditis elegans
Creators: name: Johnston, Christopher A.
name: Siderovski, David P.
name: Willard, Francis S.
name: Gönczy, Pierre
name: Snyder, Jason T.
name: Afshar, Katayoun
name: Tall, Gregory G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Heterotrimeric G-proteins are integral to a conserved regulatory module that influences metazoan asymmetric cell division (ACD). In the Caenorhabditis elegans zygote, GOA-1 (Gαo) and GPA-16 (Gαi) are involved in generating forces that pull on astral microtubules and position the spindle asymmetrically. GPA-16 function has been analyzed in vivo owing notably to a temperature-sensitive allele gpa-16(it143), which, at the restrictive temperature, results in spindle orientation defects in early embryos. Here we identify the structural basis of gpa-16(it143), which encodes a point mutation (G202D) in the switch II region of GPA-16. Using Gαi1(G202D) as a model in biochemical analyses, we demonstrate that high temperature induces instability of the mutant Gα. At the permissive temperature, the mutant Gα was stable upon GTP binding, but switch II rearrangement was compromised, as were activation state-selective interactions with regulators involved in ACD, including GoLoco motifs, RGS proteins, and RIC-8. We solved the crystal structure of the mutant Gα bound to GDP, which indicates a unique switch II conformation as well as steric constraints that suggest activated GPA-16(it143) is destabilized relative to wild type. Spindle severing in gpa-16(it143) embryos revealed that pulling forces are symmetric and markedly diminished at the restrictive temperature. Interestingly, pulling forces are asymmetric and generally similar in magnitude to wild type at the permissive temperature despite defects in the structure of GPA-16(it143). These normal pulling forces in gpa-16(it143) embryos at the permissive temperature were attributable to GOA-1 function, underscoring a complex interplay of Gα subunit function in ACD.
(4043) Margaret Brown
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Hydroxyapatite crystal deposition disease: A common entity in uncommon locations.
Creators: name: Sekhon, Rupinder
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Musculoskeletal bone
subject: Musculoskeletal soft tissue
subject: Musculoskeletal joint
subject: CT
subject: MR
subject: Diagnostic procedure
subject: Acute
subject: Calcifications / Calculi

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: Hydroxyapatite crystal deposition disease (HADD) is a common periarticular pathology, most frequently observed in the shoulder 1 . Although deposits are usually asymptomatic, clinical presentation from symptomatic lesions may mimic infection or...
Semantic Enrichment of Mobile Phone Data Records Using Background Knowledge
Creators: name: Dashdorj, Zolzaya
name: Sobolevsky, Stanislav
name: Serafini, Luciano
name: Antonelli, Fabrizio
name: Ratti, Carlo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Artificial Intelligence (cs.AI)
subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences
subject: H.1.2; H.2.8; H.3.3; I.2.3; I.2.4; G.3
subject: 68

description: Every day, billions of mobile network events (i.e. CDRs) are generated by cellular phone operator companies. Latent in this data are inspiring insights about human actions and behaviors, the discovery of which is important because context-aware applications and services hold the key to user-driven, intelligent services, which can enhance our everyday lives such as social and economic development, urban planning, and health prevention. The major challenge in this area is that interpreting such a big stream of data requires a deep understanding of mobile network events' context through available background knowledge. This article addresses the issues in context awareness given heterogeneous and uncertain data of mobile network events missing reliable information on the context of this activity. The contribution of this research is a model from a combination of logical and statistical reasoning standpoints for enabling human activity inference in qualitative terms from open geographical data that aimed at improving the quality of human behaviors recognition tasks from CDRs. We use open geographical data, Openstreetmap (OSM), as a proxy for predicting the content of human activity in the area. The user study performed in Trento shows that predicted human activities (top level) match the survey data with around 93% overall accuracy. The extensive validation for predicting a more specific economic type of human activity performed in Barcelona, by employing credit card transaction data. The analysis identifies that appropriately normalized data on points of interest (POI) is a good proxy for predicting human economical activities, with 84% accuracy on average. So the model is proven to be efficient for predicting the context of human activity, when its total level could be efficiently observed from cell phone data records, missing contextual information however.
description: 40 pages, 34 figures
Additional file 1 of “There is no joy in the family anymore”: a mixed-methods study on the experience and impact of maternal mortality on families in Ghana
Creators: name: Lawrence, Emma R.
name: Appiah-Kubi, Adu
name: Lawrence, Hannah R.
name: Lui, Maxine Y.
name: Owusu-Antwi, Ruth
name: Konney, Thomas
name: Moyer, Cheryl A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. Linearregression analyses evaluating predictors of depressive symptoms followingmaternal death.
Diagrams and Parastatistical Factors for Cascade Emission of a Pair of Paraparticles
Creators: name: Nelson, Charles A.
name: Kraynova, Margarita
name: Mera, Calvin S.
name: Shapiro, Alanna M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The empirical absence to date of particles obeying parastatistics in high energy collider experiments might be due to their large masses, weak scale couplings, and lack of gauge couplings. Paraparticles of order p=2 must be pair produced, so the lightest such particles are absolutely stable and so are excellent candidates to be associated with dark matter and/or dark energy. If there is a portal to such particles, from a new scalar A1 boson they might be cascade emitted as a pair of para-Majorana neutrinos as in A1 ---> A2 para-nu para-nu or as a pair of neutral spin-zero paraparticles such as in A1 ---> A2 para-A para-B, where para-B is the anti-paraparticle to para-A. In this paper, for an assumed supersymmetric-like "statistics portal" Lagrangian, the associated connected tree diagrams and their parastatistical factors are obtained for the case of order p=2 parastatistics. These factors are compared with the corresponding statistical factors for the analogous emission of a non-degenerate or a 2-fold degenerate pair which obey normal statistics. This shows that diagrams, and diagrammatic thinking, can be use in perturbatively analyzing paraparticle processes. The parastatistical factor associated with each diagram does require explicit calculation.
description: 14 pages, 10 figures, present paper makes our earlier overlapping arXiv:1310.7798 obsolete; v2: Corrects P-bar-sum eigenvalue (after A6), same as PRD 93