Additional file 1 of Blood-based epigenome-wide analyses of cognitive abilities
Creators: name: McCartney, Daniel L.
name: Hillary, Robert F.
name: Conole, Eleanor L. S.
name: Banos, Daniel Trejo
name: Gadd, Danni A.
name: Walker, Rosie M.
name: Nangle, Cliff
name: Flaig, Robin
name: Campbell, Archie
name: Murray, Alison D.
name: Maniega, Susana Muñoz
name: Valdés-Hernández, María del C.
name: Harris, Mathew A.
name: Bastin, Mark E.
name: Wardlaw, Joanna M.
name: Harris, Sarah E.
name: Porteous, David J.
name: Tucker-Drob, Elliot M.
name: McIntosh, Andrew M.
name: Evans, Kathryn L.
name: Deary, Ian J.
name: Cox, Simon R.
name: Robinson, Matthew R.
name: Marioni, Riccardo E.
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: Additional file 1: Supplementary Tables 1-13. Table S1: Generation Scotland cohort summary. Table S2: Mean variance accounted for by the effects of DNA methylation (DNAm) and genome-wide DNA single nucleotide polymorphisms (GWAS) alone, DNAm data conditioned on GWAS data (DNAmAdjGWAS), and the additive effects of DNAm and GWAS data for six cognitive traits. Table S3: Comparison of epigenetic variance components estimates between BayesR+ and a linear mixed model approach, OSCA. Table S4: Contribution of mixtures with small, medium, and large effect sizes (variances of 0.01%, 0.1%, and 1%, respectively) to the mean variance accounted for by the effects of DNA methylation (DNAm) for the cognitive traits. Table S5: List of blood-based CpG sites that are with strong evidence (Group PIP&gt;0.95) for association with general cognitive function in Generation Scotland. PIP: Posterior Inclusion Probability. Table S6: Epigenome-wide association study (EWAS) catalog lookup of three CpGs with strong (Group PIP&gt;0.95) associations with general cognitive ability. Table S7: Lookup of CpGs associated with cognitive abilities and Alzheimer’s disease. Table S8: LBC1921 and LBC1936 Cohort Summaries. Table S9: Correlations between measured white blood cell counts and cognitive EpiScore in LBC1921 and LBC1936. Table S10: Age- and sex-adjusted linear regression associations between the cognitive g Epigenetic Score (EpiScore) and measured g score and traits associated with cognitive ageing and dementia (outcomes) in the Lothian Birth Cohorts 1936 and 1921. Table S11: Multiple regression output from a saturated model comprised of measured g (outcome) age, sex, 10 health and lifestyle traits, and the EpiScore for general cognitive function (predictors). Table S12: Age- and sex-adjusted linear regression associations between 70 inflammation-related and 90 neurology related proteins (outcomes) with the cognitive g Epigenetic Score (EpiScore) and measured cognitive ability in the Lothian Birth Cohort 1936. Table S13: Age at MRI scan- and sex-adjusted linear regression associations between the Epigenetic g Score (EpiScore) and measured g score and traits associated with global neuroimaging outcomes in the Lothian Birth Cohorts 1936.