cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
LA CAÍDA DEL LEVIATÁN (THE EXPANSE 9) leer el libro
Creators: name: Alexander
Publisher: name: Zenodo
Year: 2024

description: LA CAÍDA DEL LEVIATÁN (THE EXPANSE 9) de JAMES S. A. COREY

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Ficha técnica

LA CAÍDA DEL LEVIATÁN (THE EXPANSE 9)

JAMES S. A. COREY

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788418037474

Editorial: NOVA

Año de edición: 2024

 

 

 

 

 

Descarga libros para iphone 3 LA CAÍDA DEL LEVIATÁN (THE EXPANSE 9) in Spanish 9788418037474

 

Overview

Así acaba todo. El explosivo cierre de la serie superventas galardonada con el Premio Hugo 2020 a la mejor saga y en la que se basa la adaptación de TV The Expanse. «El equivalente, en clave de ciencia ficción, de Canción de hielo y fuego». NPR Books El imperio de Laconia ha caído y los mil trescientos sistemas planetarios han logrado liberarse del gobierno de Winston Duarte. Pero el antiguo enemigo que acabó con los constructores de las puertas ha despertado, y la guerra contra nuestro universo ha vuelto a comenzar. En el sistema muerto de Adro, Elvi Okoye lidera una misión científica casi imposible con el objetivo de comprender qué eran los constructores y qué fue lo que acabó con ellos, aunque eso signifique ponerse en peligro a sí misma y a los niños híbridos, los sujetos medio alienígenas medio humanos de su investigación. Entretanto, la coronel Aliana Tanaka se dedica a buscar a la hija desaparecida de Duarte por la inmensidad de la galaxia… y también al mismísimo y destrozado emperador. Y, en la Rocinante, James Holden y su tripulación se afanan por crear un futuro para la humanidad a partir de los vestigios y las ruinas de lo que antaño existió. Así pues, mientras unas fuerzas casi inimaginables se preparan para aniquilar la humanidad, Holden y un grupo de aliados imposibles dan al fin con una última y desesperada oportunidad para unirla con la promesa de una vasta civilización galáctica libre de guerras, facciones, mentiras y secretos, en caso de que consigan la victoria. Pero el precio a pagar por ella puede ser mayor que el coste de la derrota.
An efficient, compact, and versatile fiber double scrambler for high precision radial velocity instruments
Creators: name: Halverson, Samuel
name: Roy, Arpita
name: Mahadevan, Suvrath
name: Ramsey, Lawrence
name: Levi, Eric
name: Schwab, Christian
name: Hearty, Fred
name: MacDonald, Nick
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We present the design and test results of a compact optical fiber double-scrambler for high-resolution Doppler radial velocity instruments. This device consists of a single optic: a high-index $n$$\sim$2 ball lens that exchanges the near and far fields between two fibers. When used in conjunction with octagonal fibers, this device yields very high scrambling gains and greatly desensitizes the fiber output from any input illumination variations, thereby stabilizing the instrument profile of the spectrograph and improving the Doppler measurement precision. The system is also highly insensitive to input pupil variations, isolating the spectrograph from telescope illumination variations and seeing changes. By selecting the appropriate glass and lens diameter the highest efficiency is achieved when the fibers are practically in contact with the lens surface, greatly simplifying the alignment process when compared to classical double-scrambler systems. This prototype double-scrambler has demonstrated significant performance gains over previous systems, achieving scrambling gains in excess of 10,000 with a throughput of $\sim$87% using uncoated Polymicro octagonal fibers. Adding a circular fiber to the fiber train further increases the scrambling gain to $>$20,000, limited by laboratory measurement error. While this fiber system is designed for the Habitable-zone Planet Finder spectrograph, it is more generally applicable to other instruments in the visible and near-infrared. Given the simplicity and low cost, this fiber scrambler could also easily be multiplexed for large multi-object instruments.
description: 10 pages, 13 figures, accepted in ApJ
title: Developing Cultural Competence Among Sixth-Grade Students Through Indigenous Knowledge and Place-Based Education
Creators: name: Roanhorse, Tyus
Publisher: name: Utah State University
Year: 2022

description: There is a need to develop cultural competence in educational settings. While there is a focus on training K-12 educators to be culturally competent, there is little focus on developing and examining the impact of student cultural competence training. Integrating Indigenous knowledge in an education setting is a unique way to start developing cultural competency by recognizing cross-cultural worldviews and perspectives. This can be done while using place-based education, which links the classroom to the cultural environment that has significant meaning to Indigenous peoples while enriching the learning experience for all students. The current study examines and measures the development of cultural competence among students from a culturally disruptive pedagogy that uses Indigenous knowledge and a diverse place-based field experience. Participants were sixth-grade students (N= 39) from an elementary school in northern Utah. The students participated in a field experience to the San Juan region located on the boarder of the Navajo Nation and participated in Indigenous knowledge lessons. A repeated measures ANOVA was used to examine the development of cultural competency across three time points throughout the school year. Findings showed significant differences in student perspective-taking, but no significant differences in other domains of cultural competence. The current study brings awareness to the development of cultural competence among youth through Indigenous knowledge and a place-based learning field experience.
(3496) Robert Roddick Ackrill Breare
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
PDF [Download] Cover Story by Rachel Lacey
Creators: name: Chichester
Publisher: name: Zenodo
Year: 2024

description: Cover Story by Rachel Lacey

 

 

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Cover Story

Rachel Lacey

Page: 299

Format: pdf, ePub, mobi, fb2

ISBN: 9781662517402

Publisher: Amazon Publishing

 

Download from google books online Cover Story CHM MOBI iBook (English Edition) by Rachel Lacey

Cover Story: A Novel - Rigetti, Susan: Books Writing during the day and accompanying Cat to extravagant parties at night, Lora's life quickly shifts from looming nightmare to dream-come-true. But as Lora  Cover Story | Buy Stylish Western Wear for Women Online Elegant dresses, modish tops, comfy jumpsuits, Cover Story's new range of women's wear is worth checking out. Shop the latest western wear for women now! Cover Story Primary Menu · Cover Story · DeKalb HS 'Man of Steel' wins CSO's Young Artist Comp. · Local HS senior wows crowd at IHSA Basketball Finals · Why Skilling is  Cover Story Vision Canvas The Cover Story Vision Canvas challenges you and your team to project yourselves in the future: how will the world respond to what you have accomplished? Coverstories: Stunning advertorials, effortlessly created. Tease readers with a beautiful cover. Make them open a story in a format of your choice. Branded article. Keep readers hooked from start to finish with our  Cover Story Introducing Cover Story, a New Investigative Podcast From New York MagazineHost iO Tillett Wright uncovers the secrets of psychedelic therapy. Listen to the  «Cover Story» в Apple Podcasts The story of a billionaire with a hero complex, the ex-spy who turned his life inside out, and us, the reporters who got caught up in their macho drama. Cover  Cover Story Podcast: House Full of Shit Jan 5, 2022 — Cover Story Cover Story. 2,24832 पसंद · 98 इस बारे में बात कर रहे हैं · 16 यहाँ थे. A FAST FASHION BRAND THAT DESIGNS & DELIVERS THE LATEST GLOBAL TRENDS TO Cover Story Vision® Canvas The cover story canvas ® challenges you and your team to project yourselves in the future: how will the world respond to what you have accomplished at that time  cover-story | Журнал Правила жизни В этом разделе собраны материалы с тегом cover-story. About Cover Story - Middle School Writing Curriculum for Learn more about Cover Story, a unique and engaging middle school writing curriculum for homeschool. Your student will write their own magazine,
Cyclic diguanylate regulates virulence factor genes via multiple riboswitches in Clostridium difficile
Creators: name: McKee, R.W.
name: Tamayo, R.
name: Harvest, C.K.
Publisher: name: American Society for Microbiology
Year: 2018

description: The intracellular signaling molecule cyclic diguanylate (c-di-GMP) regulates many processes in bacteria, with a central role in controlling the switch between motile and nonmotile lifestyles. Recent work has shown that in Clostridium difficile (also called Clostridioides difficile), c-di-GMP regulates swimming and surface motility, biofilm formation, toxin production, and intestinal colonization. In this study, we determined the transcriptional regulon of c-di-GMP in C. difficile, employing overexpression of a diguanylate cyclase gene to artificially manipulate intracellular c-di-GMP. Consistent with prior work, c-di-GMP regulated the expression of genes involved in swimming and surface motility. c-di-GMP also affected the expression of multiple genes encoding cell envelope proteins, several of which affected biofilm formation in vitro. A substantial proportion of the c-di-GMP regulon appears to be controlled either directly or indirectly via riboswitches. We confirmed the functionality of 11 c-di-GMP riboswitches, demonstrating their effects on downstream gene expression independent of the upstream promoters. The class I riboswitches uniformly functioned as "off" switches in response to c-di-GMP, while class II riboswitches acted as "on" switches. Transcriptional analyses of genes 3= of c-di-GMP riboswitches over a broad range of c-di-GMP levels showed that relatively modest changes in c-di-GMP levels are capable of altering gene transcription, with concomitant effects on microbial behavior. This work expands the known c-di-GMP signaling network in C. difficile and emphasizes the role of the riboswitches in controlling known and putative virulence factors in C. difficile.
title: Programming Process, Patterns and Behaviors: Insights from Keystroke Analysis of CS1 Students
Creators: name: Shrestha, Raj
Publisher: name: Utah State University
Year: 2022

description: With all the experiences and knowledge, I take programming as granted. But learning to program is still difficult for a lot of introductory programming students. This is also one of the major reasons for a high attrition rate in CS1 courses. If instructors were able to identify struggling students then effective interventions can be taken to help them. This thesis is a research done on programming process data that can be collected non-intrusively from CS1 students when they are programming. The data and their findings can be leveraged in understanding students’ thought process, detecting patterns and identifying behaviors that could possibly help instructors to identify struggling students, help them and design better courses.
Characterization of flagellum and toxin phase variation in Clostridioides difficile ribotype 012 isolates
Creators: name: Maldonado-Vazquez, N.
name: Tamayo, R.
name: Anjuwon-Foster, B.R.
Publisher: name: American Society for Microbiology
Year: 2018

description: Clostridioides difficile causes diarrheal diseases mediated in part by the secreted toxins TcdA and TcdB. C. difficile produces flagella that also contribute to motility and bacterial adherence to intestinal cells during infection. Flagellum expression and toxin gene expression are linked via the flagellar alternative sigma factor, SigD. Recently, we identified a flagellar switch upstream of the early flagellar biosynthesis operon that mediates phase variation of both flagellum and toxin production in C. difficile strain R20291. However, we were unable to detect flagellar switch inversion in C. difficile strain 630, a ribotype 012 strain commonly used in research labs, suggesting that the strain is phase locked. To determine whether a phase-locked flagellar switch is limited to 630 or present more broadly in ribotype 012 strains, we assessed the frequency and phenotypic outcomes of flagellar switch inversion in multiple C. difficile ribotype 012 isolates. The laboratory-adapted strain JIR8094, a derivative of strain 630, and six clinical and environmental isolates were all found to be phase-off, nonmotile, and attenuated for toxin production. We isolated low-frequency motile derivatives of JIR8094 with partial recovery of motility and toxin production and found that additional changes in JIR8094 impact these processes. The clinical and environmental isolates varied considerably in the frequency by which flagellar phase-on derivatives arose, and these derivatives showed fully restored motility and toxin production. Taken together, these results demonstrate heterogeneity in flagellar and toxin phase variation among C. difficile ribotype 012 strains and perhaps other ribotypes, which could impact disease progression and diagnosis.
DOWNLOAD [PDF] {EPUB} The Book of Animal Secrets: Nature's Lessons for a Long and Happy Life by David B. Agus
Creators: name: Levasseur
Publisher: name: Zenodo
Year: 2024

description: The Book of Animal Secrets: Nature's Lessons for a Long and Happy Life by David B. Agus

 

 

Download Book ➡ Link

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The Book of Animal Secrets: Nature's Lessons for a Long and Happy Life

David B. Agus

Page: 416

Format: pdf, ePub, mobi, fb2

ISBN: 9781668043578

Publisher: Simon & Schuster

 

Free computer books downloading The Book of Animal Secrets: Nature's Lessons for a Long and Happy Life ePub by David B. Agus

Overview

From the #1 New York Times bestselling author of The End of Illness comes an ingenious guide to what our fellow animals can teach us about living longer, healthier, happier lives. Mother nature has a lot to teach us, if only we open our eyes. Pigeons and dolphins offer creative strategies for preserving our memories and warding off dementia, while squirrels and pigs harbor secrets for managing chronic pain. Rhinoceroses demonstrate the subtle power of our environments—and how to exercise better—while chimps have surprising parenting tips, not to mention great diet advice. Studying elephants has unlocked insights into preventing cancer, and we can look to giraffes for solutions to cardiovascular issues. Ants reveal the unusual benefits of collaboration and altruism, dogs are masterful mentors in living the good life, prairie voles hold clues to connection, and hitchhikers from our evolutionary past may bring us to the edge of immortality. In The Book of Animal Secrets, visionary physician and biomedical researcher David B. Agus, MD, explores all these ways—and more—that we can harness the wonders of the animal kingdom in our own, very human lives. Filled with lively storytelling and astonishing practical takeaways, this revelatory guide will have you rethinking what’s possible for your health and wellbeing—now and for years to come.
title: Natural and Experimental Slow Slip Observed Along Shallow Hematite Faults
Creators: name: DiMonte, Alexandra A.
Publisher: name: Utah State University
Year: 2022

description: Fault slip relieves stress in the shallow crust by slipping suddenly during earthquakes, but some faults also slip slowly in between earthquakes. Exhumed faults, brought up to the Earth’s surface from depth, preserve a record of fault processes and slip rates informed by fault rock structures, textures, and chemistry. Hematite, a common iron oxide mineral that precipitates on fault surfaces, exhibits crystal textures that potentially indicate past slip rate. Hematite can be dated using the radioisotopic system of (U-Th)/He thermochronometry, which constrains the time when He is trapped within a crystal, a process that is a function of temperature. Exhumed faults that are parallel and connect to the San Andreas Fault (southernmost California) at depth cut crystalline rock and contain networks of small, hematite-coated faults. Here, hematite displays crystal morphology and structures that indicate hematite formed episodically a formation, repeatedly slipped at slow rates. Hematite (U-Th)/He dates show hematite formed at shallow depths (
title:  Modernità, postmodernità, postmedievalità
Creators: name: Maffesoli, Michel
Publisher: name: Roma TrE-Press
Year: 2016

description: A partire dalla nozione di «episteme» e di «paradigma» il saggio mostra come il cambiamento dei valori sociali, osservati empiricamente nella vita quotidiana, ci induca a pensare che, saturatosi un ciclo, quello della modernità, sta per incominciarne un altro che, in mancanza di un termine migliore, possiamo chiamare «postmoderno». A partire da qualche indizio rinvenuto in particolare nelle pratiche giovanili, si può provare ad indicare quali siano le ‘caratteristiche essenziali’ della società in gestazione, tenendo sempre presente la complessità della negoziazione del sociale attraverso una produzione discorsiva istituzionale, omogeneizzante, ideologica. In particolare, il saggio si concentrerà sul rapporto fra la configurazione dell’individuo nella modernità (o postmedievalità) e la condizione postmoderna, secondo un’articolazione geopolitica specifica in cui le comunità tradizionali si dissolvono in una nuova dimensione sociale (contesa fra ‘babelizzazione’ e globalizzazione).
description: Modernità nelle Americhe
(3497) Sybelle Jessie MacDuff Breare
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Holocene Chronostratigraphy of Dune Fields in Southern Utah: Geomorphic Record of Past Aridity in the Central Colorado Plateau
Creators: name: Cornachione, Harriet S.
Publisher: name: Utah State University
Year: 2022

description: The southwestern United States is characterized by dry climate, and droughts are common. The region is currently in an extreme drought that began in 2000 CE and has lasted longer than any previous drought in at least 500 years. Models predict greater future climate extremes under human-caused climate change. Understanding of the natural range of climate variability is important to put these changes in context. Sedimentary archives of past sand dune activity can help extend the available instrumental observations (last century) and tree-ring records (last millennium).
Sand dunes are landforms that are sensitive to aridity and decreased vegetation cover. They can reactivate and migrate downwind during periods of aridity leaving behind a sediment record of past dune field activity. Research goals were to reconstruct past dune activity the Kanab and San Rafael dune fields in southern Utah. This was accomplished by mapping the dune forms and sampling for age control and sediment character. Modern wind data were compared to the orientation of the older dune forms to determine if wind directions have changed.
The Kanab dune field, in southwestern Utah, was found to have been active five times over the last 10,000 yr. The data indicate 1000 yr-long periods of activity separated by similar duration periods of stability. The San Rafael dune field, in east central Utah contained records of seven episodes of eolian activity from late Pleistocene (~17,000 years ago) to the present. Dunes are active today in this dune field with thinner dune deposits and sparser vegetation suggesting greater wind erosion than in the Kanab dune field. Comparing records between the two dune fields indicates three time periods when they were both actively migrating, suggesting regional aridity ~9,500-7,500, 2000-1500 and 1000-500 years ago. Expanding this comparison to existing sand dune records across the Colorado Plateau suggests at least these three periods, and as many as five periods of regional aridity, may have occurred in the last 10,000 years. Wind and geochemical data indicate similar wind and source sediments have been active over the history of the dune fields.
title: Investigating Factors That Impact Income Generation and Distribution in Western National Park Gateway Communities
Creators: name: Depew, Elizabeth
Publisher: name: Utah State University
Year: 2022

description: Many rural towns in the western united states have come to be defined by high levels of tourism, seasonal residents, and migration driven by the desire to be close to natural amenities and the higher quality of life they afford. This shift is especially apparent in communities that are “gateways” to natural amenities such as national parks. Embracing this shift towards the “New West,” many community planners have heralded amenity-led development as a remedy to the waning feasibility of relying on agriculture and extractive industries. However, anecdotal evidence and several case studies indicate the factors which make these gateway communities unique can lead to a lower incomes and increased income inequality. This work is a regional study of the factors that effect income generation and distribution in western gateway communities near national parks. Through an examination of the literature, seven unique variables were identified as having the potential to effect income and income inequality in gateway communities; these variables were: park visitation, proximity to park visitor’s center, number of other gateway communities within 16.1 km (10 miles) of the park, the population size of the gateway community, it’s migration rate, it’s proportion of seasonal residential units, and it’s proportion of jobs in the leisure and hospitality industry.
Using data from the American Community Survey as well as open-source GIS, I investigate two primary research questions: Research question 1: Are there significant trends in the income profiles of gateway communities? And, do these trends in income profiles differ from comparable non-gateway communities? Research question 2: Are there significant relationships between the unique characteristics of gateway communities and the income generation and distribution within these communities?
 Results suggest a negative trend in gateway community earnings from 2010 to 2019. In addition, gateway communities have had significantly lower mean earnings than comparable benchmark communities. The proportion of in-migration, the proportion of seasonal residential units, the proportion of jobs in the leisure and hospitality industry, and the interaction between the latter two variables had a significant and negative impact on income in gateway communities. In my discussion, I detail how these results can guide community planning and decision making within gateway communities outside of national parks.
Type IV pili promote Clostridium difficile adherence and persistence in a mouse model of infection
Creators: name: Tamayo, R.
name: Garrett, E.M.
name: Aleksanyan, N.
name: McKee, R.W.
Publisher: name: American Society for Microbiology
Year: 2018

description: Cyclic diguanylate (c-di-GMP) is a second messenger that regulates the transition from motile to sessile lifestyles in numerous bacteria and controls virulence factor production in a variety of pathogens. In Clostridium difficile, c-di-GMP negatively regulates flagellum biosynthesis and swimming motility and promotes the production of type IV pili (TFP), biofilm formation, and surface motility in vitro. Flagella have been identified as colonization factors in C. difficile, but the role of TFP in adherence to host cells and in colonization of the mammalian gut is unknown. Here we show that c-di-GMP promotes adherence to epithelial cells in vitro, which can be partly attributed to the loss of flagella. Using TFP-null mutants, we demonstrate that adherence to epithelial cells is partially mediated by TFP and that this TFP-mediated adherence requires c-di-GMP regulation. In a mouse model of colonization, the TFP-null mutants initially colonized the intestine as well as the parental strain but were cleared more quickly. Moreover, compared to the parent strain, C. difficile strains lacking TFP were particularly deficient in association with the cecal mucosa. Together these data indicate that TFP and their positive regulation by c-di- GMP promote attachment of C. difficile to the intestinal epithelium and contribute to persistence of C. difficile in the host intestine.
MEMORIAS DE UN VIVIDOR. ERROL FLYNN ePub gratis
Creators: name: Atkinson
Publisher: name: Zenodo
Year: 2024

description: MEMORIAS DE UN VIVIDOR. ERROL FLYNN de ERROL FLYNN

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Ficha técnica

MEMORIAS DE UN VIVIDOR. ERROL FLYNN

ERROL FLYNN

Número de páginas: 404

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788412379198

Editorial: CULT BOOKS

Año de edición: 2021

 

 

 

 

 

Descarga gratuita de libros de audio del Reino Unido MEMORIAS DE UN VIVIDOR. ERROL FLYNN (Literatura española) de ERROL FLYNN iBook

 

Overview

Para los millones de espectadores que le adoraron como Robin Hood, como el Capitán Blood,como Fletcher Christian, como George Armstrong Custer, Errol Flynn (1909-1959) vivió una vidamucho más emocionante que cualquiera de las aventuras que llevó a la pantalla: viajes exóticos,hazañas criminales, relaciones con mujeres hermosas, confrontaciones violentas, acusaciones deestupro, escándalos, fama internacional. En esta autobiografía, el legendario actor desnuda su viday su personalidad como nunca lo había hecho antes.Memorias de un vividor es la crónica desacomplejada de la tumultuosa vida de un hombre queno era inmoral, sino amoral. Nunca habríamos sospechado que Errol Flynn fuera un escritordivertido y brillante, pero a juzgar por sus memorias es todo eso y más. Lo que sorprenderá a lagente que conoció al Flynn de los sórdidos titulares que marcaron su vida (y su muerte) es elretrato que emerge de un hombre sensible, inteligente y sabio.La suya fue una vida de incesante búsqueda del placer. Pero este libro constituye, además, unimpagable documento sobre el mundo de Hollywood, salpicado con abundante chismografíacinematográfica e irreverentes retratos de personalidades del séptimo arte. Memorias de unvividor describe con detalle el olfato propio de un anecdotista nato y el
Editorial overview: Bacterial cell regulation: from genes to complex environments
Creators: name: Veening, J.-W.
name: Tamayo, R.
Publisher: name: Elsevier Ltd
Year: 2018

description: Scientists, funding agencies, policy makers, and the general public have come to appreciate and embrace the societal and environmental relevance of the microbial world. For instance, in 2014, the first museum dedicated entirely to microbes was opened (https://www.micropia.nl/). Microbiology has become a truly interdisciplinary field, and this, combined with recent technological advances in areas such as DNA sequencing, gene editing, and fluorescence microscopy, is revolutionizing our knowledge of microbial life. Recent work on how bacterial cells regulate basic processes such as DNA replication and division and central metabolism reveal remarkable elegance and sophistication in the control mechanisms involved. In addition to these core functions, bacteria have evolved numerous strategies to make the best of their environment. Consider chemotaxis and bacterial exploration towards new nutrient-rich niches, production of nanotubes to transmit information with others, immune evasion of the host they are feeding off, or killing competitors in their environment. In this issue of Current Opinion in Microbiology, we highlight new insights in bacterial regulation in its broadest sense. New developments in understanding bacterial chromosomal organization to regulation of anti-bacteriophage CRISPR systems are discussed. The latest technologies for studying bacterial life that have made these advances possible, such as single cell (dual) RNA-seq, are also discussed. The overall picture emerging from this collection of reviews is that tremendous progress is being made towards our understanding of the molecular basis of bacterial cell regulation, demonstrating the versatility, flexibility, and exquisite regulation that bacteria employ.
Coulomb drag
Creators: name: Narozhny, B. N.
name: Levchenko, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Other Condensed Matter (cond-mat.other)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Coulomb drag is a transport phenomenon whereby long-range Coulomb interaction between charge carriers in two closely spaced but electrically isolated conductors induces a voltage (or, in a closed circuit, a current) in one of the conductors when an electrical current is passed through the other. The magnitude of the effect depends on the exact nature of the charge carriers and microscopic, many-body structure of the electronic systems in the two conductors. Drag measurements have become part of the standard toolbox in condensed matter physics that can be used to study fundamental properties of diverse physical systems including semiconductor heterostructures, graphene, quantum wires, quantum dots, and optical cavities.
description: Review article, 59 pages, 35 figures, lots of references (pages 52-59); submitted to Reviews of Modern Physics
(3498) Blodwen Lloyd Williams
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Genome-wide detection of conservative site-specific recombination in bacteria
Creators: name: Camilli, A.
name: Mathias Garrett, E.
name: Sekulovic, O.
name: Shen, A.
name: Bourgeois, J.
name: Tamayo, R.
Publisher: name: Public Library of Science
Year: 2018

description: The ability of clonal bacterial populations to generate genomic and phenotypic heterogeneity is thought to be of great importance for many commensal and pathogenic bacteria. One common mechanism contributing to diversity formation relies on the inversion of small genomic DNA segments in a process commonly referred to as conservative site-specific recombination. This phenomenon is known to occur in several bacterial lineages, however it remains notoriously difficult to identify due to the lack of conserved features. Here, we report an easy-to-implement method based on high-throughput paired-end sequencing for genome-wide detection of conservative site-specific recombination on a single-nucleotide level. We demonstrate the effectiveness of the method by successfully detecting several novel inversion sites in an epidemic isolate of the enteric pathogen Clostridium difficile. Using an experimental approach, we validate the inversion potential of all detected sites in C. difficile and quantify their prevalence during exponential and stationary growth in vitro. In addition, we demonstrate that the master recombinase RecV is responsible for the inversion of some but not all invertible sites. Using a fluorescent gene-reporter system, we show that at least one gene from a two-component system located next to an invertible site is expressed in an on-off mode reminiscent of phase variation. We further demonstrate the applicability of our method by mining 209 publicly available sequencing datasets and show that conservative site-specific recombination is common in the bacterial realm but appears to be absent in some lineages. Finally, we show that the gene content associated with the inversion sites is diverse and goes beyond traditionally described surface components. Overall, our method provides a robust platform for detection of conservative site-specific recombination in bacteria and opens a new avenue for global exploration of this important phenomenon.
Additional methods and tables from Living on the edge of a shrinking habitat: the ivory gull, Pagophila eburnea, an endangered sea-ice specialist.
Creators: name: Gilg, Olivier
name: Istomina, Larysa
name: Heygster, Georg
name: Strøm, Hallvard
name: Gavrilo, Maria V.
name: Mallory, Mark L.
name: Gilchrist, Grant
name: Aebischer, Adrian
name: Sabard, Brigitte
name: Huntemann, Marcus
name: Mosbech, Anders
name: Yannic, Glenn
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Living on the edge of a shrinking habitat: the ivory gull, Pagophila eburnea, an endangered sea-ice specialist
Phase variation of Clostridium difficile virulence factors
Creators: name: Tamayo, R.
name: Anjuwon-Foster, B.R.
Publisher: name: Taylor and Francis
Year: 2018

description: Clostridium difficile is a leading cause of nosocomial infections, causing disease that ranges from mild diarrhea to potentially fatal colitis. A variety of surface proteins, including flagella, enable C. difficile colonization of the intestine. Once in the intestine, toxigenic C. difficile secretes two glucosylating toxins, TcdA and TcdB, which elicit inflammation and diarrheal disease symptoms. Regulation of colonization factors and TcdA and TcdB is an intense area of research in C. difficile biology. A recent publication from our group describes a novel regulatory mechanism that mediates the ON/OFF expression of co-regulated virulence factors of C. difficile, flagella and toxins. Herein, we review key findings from our work, present new data, and speculate the functional consequence of the ON/OFF expression of these virulence factors during host infection.
DOWNLOAD [PDF] {EPUB} Crescent City 3 by Sarah J. Maas
Creators: name: Johnson
Publisher: name: Zenodo
Year: 2024

description: Crescent City 3 by Sarah J. Maas

 

 

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Crescent City 3

Sarah J. Maas

Page: 816

Format: pdf, ePub, mobi, fb2

ISBN: 9781635574104

Publisher: Bloomsbury USA

 

Free computer textbook pdf download Crescent City 3 9781635574104 by Sarah J. Maas

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The stunning third book in the sexy, action-packed Crescent City series, following the global bestsellers House of Earth and Blood and House of Sky and Breath.
title: Stewards and Conservationists: Merging Moral Norms and the Theory of Planned Behavior to Understand Altruistic Conservation Behavior Among Hunters in Southwestern Utah
Creators: name: Richards, Jacob C.
Publisher: name: Utah State University
Year: 2022

description: The leading cause of mortality in California Condors (condors) is lead poisoning, which occurs when condors ingest lead-based ammunition left in carcasses. As a critically endangered species with approximately 115 individuals remaining in the American southwest, increasing the adoption of non-lead ammunition is essential to the recovery of the species. In Utah, the Division of Wildlife Resources (DWR) uses communication with hunters as the primary tool for increasing the adoption of non-lead ammunition in southwestern Utah. In this research, we use social science theory and data collected from a survey of hunters throughout the region to develop a strategic communication framework aimed at increasing the use of non-lead ammunition among hunters. The strategic communication framework is intended to drive more specific, targeted, and effective messages regarding the use of non-lead ammunition by the Utah Division of Wildlife Resources and their conservation partners.
Our findings suggest hunters, on average, hold positive attitudes towards non-lead ammunition and that their intention to use non-lead ammunition while hunting in in the area is high. This is good news for the DWR as an initial concern of the agency was that hunters may tend to hold negative attitudes towards non-lead ammunition and not be aware of the agency’s preferences and programs regarding the behavior.
We asked hunters to self-report feelings of stewardship for the landscape and for the hunting tradition, believing that these feelings could be used as key leverage points to encourage the use of non-lead ammunition. These ‘personal norms’ were very strong amongst hunters; 92.7% of hunters consider themselves to be a steward of the natural landscape where they hunt and 88.4% believe they are stewards of the hunting tradition for future generations. Given these findings, we provide specific guidance on how the DWR can target personal norms in their communication with hunters regarding the use of non-lead ammunition. Tapping into feelings of stewardship over the landscape and family traditions are likely to be the most effective for effectuation behavioral change, reducing the use of lead ammunition, and conserving the condor population.
An Altered Immune Response, but Not Individual Cationic Antimicrobial Peptides, Is Associated with the Oral Attenuation of Ara4N-Deficient Salmonella enterica Serovar Typhimurium in Mice
Creators: name: Tamayo, R.
name: Strandberg, K.L.
name: Gunn, J.S.
name: Reeves, L.T.
name: Richards, S.M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Salmonella enterica serovar Typhimurium (S. Typhimurium) uses two-component regulatory systems (TCRS) to respond to stimuli in the local microenvironment. Upon infection, the Salmonella TCRSs PhoP-PhoQ (PhoPQ) and PmrA-PmrB (PmrAB) are activated by environmental signals in the intestinal lumen and within host cells. TCRS-mediated gene expression results in lipopolysaccharide (LPS) modification and cationic antimicrobial peptide resistance. The PmrA-regulated pmrHFIJKLM operon mediates 4-amino-4-deoxy-L-arabinose (Ara4N) production and attachment to the lipid A of LPS. A ΔpmrF S. Typhimurium strain cannot produce Ara4N, exhibits increased sensitivity to cationic antimicrobial peptide (CAMP)-mediated killing, and attenuated virulence in mice upon oral infection. CAMPs are predicted to play a role in elimination of Salmonella, and may activate PhoPQ and PmrAB in vivo, which could increase bacterial resistance to host defenses. Competition experiments between wild type (WT) and ΔpmrF mutant strains of S. Typhimurium indicated that selection against this mutant first occurs within the intestinal lumen early during infection. However, CRAMP and active cryptdins alone are not responsible for elimination of Ara4N-deficient bacteria in vivo. Investigation into the early immune response to ΔpmrF showed that it differed slightly from the early immune response to WT S. Typhimurium. Further investigation into the early immune response to infection of Peyer's patches suggests a role for IL-13 in the attenution of the ΔpmrF mutant strain. Thus, prominent CAMPs present in the mouse intestine are not responsible for the selection against the ΔpmrF strain in this location, but limited alterations in innate immune induction were observed that affect bacterial survival and virulence.
Identifying new variables during infection: Proximity to the host epithelium and epigenetic programs alter the expression of virulence factors in Vibrio cholerae
Creators: name: Tamayo, R.
name: Mudrak, B.
Publisher: name: Frontiers Research Foundation
Year: 2011

description: In the life cycles of facultative pathogens, the ability to transition between the external environment and the host is key to survival. These transitions are accompanied by alterations in transcriptional and proteomic profiles (Merrell et al., 2002; Schild et al., 2007; LaRocque et al., 2008). Numerous studies have investigated the changes in gene expression that occur during these environmental shifts and have identified factors that are important for survival and growth in the two disparate settings. Less is known about the changes in gene expression that result as a pathogen transitions between microenvironments within the host or even the number of such transitions that occur. A single organ or tissue may in fact constitute a wide array of strikingly different environmental conditions for an invading pathogen.
Additional methods and tables from Living on the edge of a shrinking habitat: the ivory gull, Pagophila eburnea, an endangered sea-ice specialist
Creators: name: Gilg, Olivier
name: Istomina, Larysa
name: Heygster, Georg
name: Strøm, Hallvard
name: Gavrilo, Maria V.
name: Mallory, Mark L.
name: Gilchrist, Grant
name: Aebischer, Adrian
name: Sabard, Brigitte
name: Huntemann, Marcus
name: Mosbech, Anders
name: Yannic, Glenn
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Living on the edge of a shrinking habitat: the ivory gull, Pagophila eburnea, an endangered sea-ice specialist
Gate-tuned Superconductor-Insulator transition in (Li,Fe)OHFeSe
Creators: name: Lei, B.
name: Xiang, Z. J.
name: Lu, X. F.
name: Wang, N. Z.
name: Chang, J. R.
name: Shang, C.
name: Luo, X. G.
name: Wu, T.
name: Sun, Z.
name: Chen, X. H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The antiferromagnetic(AFM) insulator-superconductor transition has been always a center of interest in the underlying physics of unconventional superconductors. The quantum phase transition between Mott insulator with AFM and superconductor can be induced by doping charge carriers in high-Tc cuprate superconductors. For the best characterized organic superconductors of k-(BEDT-TTF)2X (X=anion), a first order transition between AFM insulator and superconductor can be tuned by applied external pressure or chemical pressure. Also, the superconducting state can be directly developed from AFM insulator by application of pressure in Cs3C60. The resemblance of these phase diagrams hints a universal mechanism governing the unconventional superconductivity in close proximity to AFM insulators. However, the superconductivity in iron-based high-Tc superconductors evolves from an AFM bad metal by doping charge carriers, and no superconductor-insulator transition has been observed so far. Here, we report a first-order transition from superconductor to insulator with a strong charge doping induced by ionic gating in the thin flakes of single crystal (Li,Fe)OHFeSe. The Tc is continuously enhanced with electron doping by ionic gating up to a maximum Tc of 43 K, and a striking superconductor-insulator transition occurs just at the verge of optimal doping with highest Tc. A novel phase diagram of temperature-gating voltage with the superconductor-insulator transition is mapped out, indicating that the superconductor -insulator transition is a common feature for unconventional superconductivity. These results help to uncover the underlying physics of iron-based superconductivity as well as the universal mechanism of high-Tc superconductivity. Our finding also suggests that the gate-controlled strong charge doping makes it possible to explore novel states of matter in a way beyond traditional methods.
description: 20 pages, 4 figures, supplementary information is not uploaded
(3499) Margaret Barbara Tennant
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Passage Probability of Woody Debris Elements and Accumulations at I- and V-Shaped Rock Weirs
Creators: name: Margetts, Kathryn
Publisher: name: Utah State University
Year: 2022

description: The transport and accumulation of driftwood or large woody debris (LWD) in mountain streams is a natural part of catchment health and river connectivity. At hydraulic structures, the presence of LWD may impact flow efficiency and influence upstream water depth. LWD has been studied at a variety of spillways and weir types, however, little is known about its interaction at rock weirs. This study investigated factors affecting the passage of individual LWD elements and any LWD accumulations at rock weirs, as well as potential impacts upstream of LWD accumulations through field-informed scaled model testing. Observations of LWD at rock weirs located on the Blacksmith Fork River, a mountain stream located in Utah, USA, were used to replicate I-and V-shaped rock weirs in a large flume. The river response to rock weirs on the corresponding section of the Blacksmith Fork River was also investigated using historic aerial imagery and field data. Approaches to LWD management typically prioritize either natural processes or hydraulic structure safety and flow conveyance. A new hybrid approach should consider both aspects for rock weirs in mountain streams.