cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Gene expression profiling and proteomic analysis of cartilage degradation in a mouse model of osteoarthritis
Creators: name: Gardiner, Matthew David
Publisher: name: Imperial College London
Year: 2011

description: Osteoarthritis (OA) is characterised by articular cartilage degradation and changes in associated joint tissues. It is a common condition, which causes significant pain and disability. Aetiological factors include age, mechanical stress, genetic predisposition and obesity. The exact sequence of molecular events in disease initiation and progression remains unclear. Treatment options are limited to symptom control and joint replacement surgery for severe disease. The aim of this research was to perform a global analysis of the gene expression and protein profile of cartilage during the early stages of OA. The destabilisation of the medial meniscus mouse (DMM) model of OA was used to study changes in the cartilage of operated or unoperated knee joints at two, four, and eight weeks following surgery. A new method was developed to retrieve articular cartilage from the mouse knee joint. This enabled proteomic analysis of the cartilage using two-dimensional difference gel electrophoresis and tandem mass spectrometry. No significant changes were seen at two or four weeks; at eight weeks both intracellular and extracellular proteins had altered abundance including small leucine rich repeat proteoglycans (SLRPs) and proteins involved in energy production and the cytoskeleton. For whole genome expression profiling, RNA was isolated from cartilage at the same time points, amplified and hybridised to Mouse WG-6 v2.0 Expression BeadChips. Validations were performed using real-time RT-PCR. Changes in gene expression were most marked at two weeks with up-regulation of metalloproteinases and SLRPs and markedly altered expression of cytoskeletal elements. These findings demonstrate the significant alteration of key biological processes related to cartilage degeneration early in the progression of OA.
A Class III Cultural Resources Reconnaissance of the Proposed Expansion of an Explosive Shipping and Receiving Area on the Tonopah Test Range, Nye County, Nevada
Creators: name: Klimowicz, Janis
Publisher: name: Desert Research Institute
Year: 1990
Subjects: Clark (County)
United States of America (Country)
Stinking Spring SW QUAD 7.5'
Las Vegas, Nevada
Nevada (State / Territory)
Nye (County)
Nellis Air Force Base, Nevada
Tonopah Test Range
26NY7523
Chipped Stone
Obsidian
Reconnaissance / Survey

description: A preactivity survey of the proposed expansion of the Sandia National Laboratories explosive shipping and receiving building in area 9 was conducted. This survey was requested to identify any cultural resources that may exist in the proposed expansion area, and to evaluate the potential for adverse effects to those cultural resources resulting from the developmental activities. The area had not been previously surveyed for cultural materials, so the area was subject to a cultural resources reconnaissance. The proposed area within the security fence was examined and it was determined that this area had been previously disturbed and no further reconnaissance would be necessary. An area outside and adjacent to the security fence which is undisturbed will also be impacted by the construction. A survey of this area revealed cultural resources.
A Cultural Resource Inventory of the West Range Diversion Dike Project, Clark County, Nevada
Creators: name: Knight & Leavitt Associates, Inc.
Year: 1992
Subjects: Clark (County)
United States of America (Country)
Las Vegas, Nevada
Nevada (State / Territory)
Nye (County)
Nellis Air Force Base, Nevada
Records Search / Inventory Checking
Systematic Survey

description: A Cultural resource inventory of the West Range Diversion Dike project on BLM land in Clark County Nevada. A total of 204 acres was surveyed. The purpose of the survey was to inventory a linear parcel for a diversion dike being constructed for the Clark County Flood Control District.
Association of NaV1.8 with lipid rafts in DRG sensory neurons
Creators: name: Pristera, Alessandro
Publisher: name: Imperial College London
Year: 2011

description: Voltage gated sodium channels (VGSCs) play a key role in the initiation and propagation of action potentials in neuronal cells. NaV1.8 is a Tetrodotoxin resistant VGSC expressed in nociceptors and underlies the majority of sodium currents during action potentials. Many studies have highlighted a key role of NaV1.8 in different pain pathways. Lipid rafts are microdomains of the plasma membrane highly enriched in cholesterol and sphingolipids characterised by unique physical features: a liquid ordered phase and the resistance to nonionic detergent at 4°C. Lipid rafts are thought to act as platforms on the membrane where proteins and lipids can be compartmentalised and functionally clustered. In the present study we investigated NaV1.8 sub-cellular localisation and explored the idea that it is associated with lipid rafts in nociceptors. We hypothesised that lipid rafts on primary sensory neurons act as a platform on the membrane where NaV1.8 can be trafficked and underlie action potentials generation. We demonstrated that NaV1.8 is associated with lipid rafts along the sciatic nerve ex vivo and in DRG neurons in vitro. We also found that NaV1.8 is distributed in clusters along the axons of DRG neurons in vitro and ex vivo. We investigated the functional meaning of NaV1.8-raft association by studying action potential propagation in sensory neurons, in response to mechanical and chemical stimulation, by calcium imaging. Disruption of the association between NaV1.8 and lipid rafts in cultured sensory neurons, by methyl-betacyclodextrin and 7-ketocholesterol, caused a reduction in the number of cells able to propagate action potentials. In addition, lipid raft depletion caused a remarkable reduction in the conduction velocity upon mechanical stimulation. These findings highlight the importance of the association between NaV1.8 and lipid rafts in the conduction of action potentials and could lead to new perspectives in the study of NaV1.8 trafficking and nociceptor excitability.
A Class III Cultural Resources Survey of Four Station Lines for the Placement of Eight Ground Motion Canisters and One GRMPY Van near U20ax Drill Pad, Pahute Mesa, Area 20 , Nevada Test Site, Nye County, Nevada
Creators: name: Holz, Barbara A.
Year: 1992
Subjects: Clark (County)
United States of America (Country)
Las Vegas, Nevada
Nevada (State / Territory)
Nye (County)
Nellis Air Force Base, Nevada
Scrugham Peak QUAD 7.5'
Reconnaissance / Survey

description: A Class III Cultural Resources Survey of Four Station Lines for the Placement of Eight Ground Motion Canisters and One GRMPY Van near U20ax Drill Pad, Pahute Mesa, Area 20 , Nevada Test Site, Nye County, Nevada.
Bruton's tyrosine kinase control of cytokine production in Toll‐like receptor signalling
Creators: name: Urbaniak, Anna Maria
Publisher: name: Imperial College London
Year: 2011

description: Inappropriate and un-regulated inflammation is the hallmark of a variety of inflammatory diseases including Rheumatoid Arthritis (RA). Central to the pathogenesis of this disease is the cytokine Tumour Necrosis Factor α (TNF), a product of activated macrophages. Macrophages are activated by numerous exogenous and endogenous ligands through Toll like receptors (TLR) leading to the activation of numerous protein tyrosine kinases (PTK). These studies have mainly described the LPS pathway and have not focused on endosomal TLRs, which are being increasingly implicated in the pathology of RA. The work presented in this thesis describes the role of Bruton's Tyrosine Kinase (Btk) in TLR8 signalling in human primary macrophages. Using an adenovirus overexpression system and RNAi technology, Btk has been shown to control the production of TNF in R848-stimulated cells. This regulation occurred on a transcriptional level as Btk downregulation decreased the level of the primary TNF transcript at 2h as well as the recruitment of RNA Polymerase II to the promoter of the TNF gene at 1h. This rapid effect of Btk depletion on gene transcription resulted in significantly less TNF protein production at 2h following R848 stimulation. Subsequent analysis of transcription factors potentially involved in the Btk-dependent regulation of TNF transcription revealed that Btk affects both NFkB and AP-1 in TLR8 signalling. In particular, Btk downregulation decreased the binding of NFkB to its consensus site as shown by EMSA as well as the recruitment of p65 to the TNF promoter or 3' enhancer region as shown by ChIP. The regulation of p65 by Btk occurred at the level of p65 phosphorylation on Serine 536 and did not affect the degradation of IkBα. AP-1 activity in EMSA was also decreased under the Btk knockdown conditions, with cJun and ATF-2 but not cFos being involved in Btk signalling. At the same time, Btk did not alter p38, ERK and JNK MAPK activity ruling out their involvement in the Btk-dependent control of AP-1 in R848-challenged macrophages. These data extend current knowledge regarding the involvement of Tec kinases in the regulation of cytokine production under inflammatory conditions by providing a potential mechanism of transcriptional control.
Arsenite removal from groundwater in a batch electrocoagulation process: Optimization through response surface methodology
Creators: name: Demirbas, Erhan
name: Kobya, Mehmet
name: Oncel, Mehmet Salim
name: Şık, Emrah
name: Aysegul Yagmur Goren
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: In this study, influences of seven process variables such as initial pH (pHi), applied current (i), operating time (tEC), initial As(III) concentration (Co), diameter of Fe ball anode (dp), column height in the electrocoagulation (EC) reactor (h) and airflow rate (Qair) for removal of As(III) from groundwater by a new air-fed fixed-bed EC reactor were evaluated with a response surface methodology (RSM). The proposed quadratic model fitted very well with the experimental data for the responses. The removal efficiencies and operating costs were determined to be 99% and 0.01 $/m3 at the optimum operating conditions (a pHi of 8.5, 0.05 A, 4.94 min, dp of 9.24 mm, h of 7.49 cm, Qair of 9.98 L/min for 50 µg/L). This study clearly showed that the RSM in the EC process was a very suitable method to optimize the operating conditions at the target value of effluent As(III) concentration (10 µg/L) while keeping the operating cost to minimal and maximize the removal efficiency.
Brief von Philipp Wolfers an Verein für Cultur und Wissenschaft der Juden, 08.08.1823
Creators: name: (:Unkn) Unknown
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1823
Subjects: subject: 090

description: zur Ministerialverfügung vom 4.12.1822
Oral history interview with Jewel Plummer Cobb 1985
Publisher: name: Columbia University
Year: 2019
Subjects: African American women executives
Women college teachers
College presidents
Education--Research
Minorities--Scholarships, fellowships, etc
Charitable uses, trusts, and foundations

description: academic background; discontent at the University of Michigan abd subsequent transfer to Talladega College in Alabama, New York University graduate school; observations of working environment of Spencer Foundation Board of Directors; need for increased support of minority scholarships; description of work as University President, California State College at Fullerton.
Finding The Lazy Programmer's Bugs
Creators: name: Allwood, Tristan Oliver Richard
Publisher: name: Imperial College London
Year: 2011

description: Traditionally developers and testers created huge numbers of explicit tests, enumerating interesting cases, perhaps biased by what they believe to be the current boundary conditions of the function being tested. Or at least, they were supposed to. A major step forward was the development of property testing. Property testing requires the user to write a few functional properties that are used to generate tests, and requires an external library or tool to create test data for the tests. As such many thousands of tests can be created for a single property. For the purely functional programming language Haskell there are several such libraries; for example QuickCheck [CH00], SmallCheck and Lazy SmallCheck [RNL08]. Unfortunately, property testing still requires the user to write explicit tests. Fortunately, we note there are already many implicit tests present in programs. Developers may throw assertion errors, or the compiler may silently insert runtime exceptions for incomplete pattern matches. We attempt to automate the testing process using these implicit tests. Our contributions are in four main areas: (1) We have developed algorithms to automatically infer appropriate constructors and functions needed to generate test data without requiring additional programmer work or annotations. (2) To combine the constructors and functions into test expressions we take advantage of Haskell's lazy evaluation semantics by applying the techniques of needed narrowing and lazy instantiation to guide generation. (3) We keep the type of test data at its most general, in order to prevent committing too early to monomorphic types that cause needless wasted tests. (4) We have developed novel ways of creating Haskell case expressions to inspect elements inside returned data structures, in order to discover exceptions that may be hidden by laziness, and to make our test data generation algorithm more expressive. In order to validate our claims, we have implemented these techniques in Irulan, a fully automatic tool for generating systematic black-box unit tests for Haskell library code. We have designed Irulan to generate high coverage test suites and detect common programming errors in the process.
Adiabatic Theory of Electron Detachment from Negative Ions in Two-Color Laser Field
Creators: name: Kuchiev, M. Yu.
name: Ostrovsky, V. N.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: Negative ion detachment in bichromatic laser field is considered within the adiabatic theory. The latter represents a recent modification of the famous Keldysh model for multiphoton ionization which makes it quantitatively reliable. We calculate angular differential detachment rates, partial rates for particular ATD (Above Threshold Detachment) channels and total detachment rates for the Hydrogen ion in a bichromatic field with 1:3 frequency ratio and various phase differences. Reliability of the present, extremely simple approach is testified by comparison with much more elaborate earlier calculations.
description: 22 pages, 6 Postscript figures
Focused microwave irradiation-assisted synthesis of N-cyclohexyl-1,2,4-oxadiazole derivatives with antitumor activity
Creators: name: Oliveira, Valentina Nascimento Melo De
name: Santos, Franciane Gonçalves Dos
name: Ferreira, Vanessa Pinheiro Gonçalves
name: Héverton Mendes Araújo
name: Pessoa, Cláudia Do Ó
name: Nicolete, Roberto
name: Oliveira, Ronaldo Nascimento De
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences

description: A facile synthesis of 3,5-disubstituted 1,2,4-oxadiazole derivatives under focused microwave irradiation (FMWI) is reported. Arylamidoximes 1a–i and dicyclohexylcarbodiimide (DCC) were carried out in DMF under FMWI to obtain 1,2,4-oxadiazoles 2a–i in 61–81% yields. All compounds exhibited antiproliferative activities in vitro against three human cancer cell lines HCT-116, PC-3, and SNB-19.
Central regulation of food intake and reproduction
Creators: name: Beale, Kylie Emma Louise
Publisher: name: Imperial College London
Year: 2011

description: The work described in this thesis investigates the actions of hypothalamic neuropeptides involved in the control of energy homeostasis and reproduction. Cerebellin 1 (Cbln1) is a 16-amino acid peptide abundantly expressed in the cerebellum and the hypothalamus. I have shown that Cbln1 increases food intake when administered centrally to rats, and that this effect may be partly mediated by neuropeptide Y. I have also demonstrated that Cbln1 mRNA expression within the ventromedial nucleus of the hypothalamus is up-regulated following a 48-hour fast, suggesting that Cbln1 may have a physiological role in the control of food intake. In addition to hypothalamic centres, the reward system has an important role in the control of feeding. The melanocortin system has a well characterised role in the homeostatic control of food intake. My work suggests that the melanocortin system may also have a previously unknown role within the ventral tegmental area (VTA) in the hedonic control of feeding. Intra- VTA administration of a melanocortin agonist reduced, whereas an antagonist increased, food intake in rats. My work suggests that the VTA melanocortin system may act upstream of dopamine signalling to influence feeding. Kisspeptin is a hypothalamic neuropeptide with a crucial role in reproduction. The hypothalamus contains two populations of kisspeptin neurones, located in the arcuate nucleus (Arc) and in the anteroventral periventricular nucleus. The physiological role of these two populations is unknown. I used recombinant adeno-associated virus (rAAV) to suppress kisspeptin expression within the Arc in female rats. Animals injected bilaterally into the Arc with rAAV-kisspeptin antisense had significantly fewer oestrous cycles, and an increase in oestrous cycle length, compared to controls. In summary, these studies have identified novel roles for Cbln1 and the melanocortin system in the control of food intake, and have demonstrated the importance of Arc kisspeptin signalling in the regulation of reproduction.
HOD modelling of high redshift galaxies using the BLUETIDES simulation
Creators: name: Bhowmick, Aklant Kumar
name: Campbell, Duncan
name: DiMatteo, Tiziana
name: Feng, Yu
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We construct halo occupation distribution (HOD) models of high redshift ($z \gtrsim 7.5$) galaxies with $M_{*}>10^8~M_{\odot}/h$ using the BlueTides hydrodynamic simulation suite, with a particular emphasis on modelling the small scale / 1-halo clustering ($0.01\lesssim r \lesssim 1~ h^{-1}\rm{Mpc}$). Similar to low redshift studies, we find that the central and satellite mean HODs ($\left$ and $\left$) can be modeled by a smoothed step function and a power law respectively. The number density of satellite galaxies is however significantly suppressed compared to low redshift (satellite fractions drop from $\sim 50 \%$ at $z=0$ to $\lesssim 10 \%$ at $z=7.5$). The mean number of satellites, $\left < 1$ for halo masses below $3 \times 10^{11} M_{\odot}/h$ (a rare halo at these redshifts). For the radial number density profiles, satellites with $10^8 \lesssim M^* \lesssim 10^{9} M_{\odot}/h$ in halos with $M_H \gtrsim 3 \times10^{11} M_{\odot}/h$ are consistent with NFW (with concentrations $c_{\mathrm{sat}} \sim 10-40$). Within halos of mass $M_H\lesssim 3 \times 10^{11} M_{\odot}/h$ satellites exhibit a power law profile with slope -3. Because these halos dominate the small scale clustering, the resulting 1-halo term is steeper than predicted using standard NFW profiles. Using this power-law profile for satellites, we can successfully reproduce the small-scale clustering exhibited by BlueTides galaxies using HOD modelling. We predict the highest probability of detecting satellites at $z>7.5$ is around centrals of $M^*\sim 3 \times 10^{10} M_{\odot}/h$ (with $M^{*}\gtrsim$ a few $10^{7} M_{\odot}/h$ ). This should be achievable with the James Webb Space Telescope (JWST).
description: 14
Gauging the Full R-Symmetry Group in Five-dimensional, N=2 Yang-Mills/Einstein/tensor Supergravity
Creators: name: Gunaydin, Murat
name: Zagermann, Marco
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We show that certain five dimensional, N=2 Yang-Mills/Einstein supergravity theories admit the gauging of the full R-symmetry group, SU(2)_R, of the underlying N=2 Poincare superalgebra. This generalizes the previously studied Abelian gaugings of U(1)_R subgroup of SU(2)_R and completes the construction of the most general vector and tensor field coupled five dimensional N=2 supergravity theories with gauge interactions. The gauging of SU(2)_R turns out to be possible only in special cases, and leads to a new type of scalar potential. For a large class of these theories the potential does not have any critical points.
description: Latex file, 15 pages ; section two is split in two and the discussion of the critical points is moved into the new section. Version to appear in Physical Review D
Catalytic Hollow Fibre Membrane Micro-reactors for Energy Applications
Creators: name: Rahman, Mukhlis Bin A
Publisher: name: Imperial College London
Year: 2011

description: An asymmetric ceramic hollow fibre is proposed as a substrate for the development of a catalytic hollow fibre microreactor (CHFMR) and a catalytic hollow fibre membrane microreactor (CHFMMR). The ceramic substrate that is prepared using the phase inversion and sintering technique has a finger-like structure and a sponge-like region in the inner region and the outer surface respectively. The finger-like structure consists of thousands of conical microchannels distributed perpendicularly to the lumen of ceramic hollow fibres onto which a catalyst is impregnated using the sol-gel Pechini method to improve a catalytic reaction. To further enhance the catalytic reaction, a membrane has been incorporated on the outer layer of ceramic hollow fibre. This study focuses on the use of palladium (Pd) and palladium/silver (Pd/Ag) membranes to separate hydrogen from reaction zones in the water-gas shift (WGS) reactions and the ethanol steam reforming (ESR) respectively. In the development of CHFMMR, the fabrication of Pd and Pd/Ag membranes is carried out prior to the catalyst impregnation process to avoid the dissolution of catalyst into the plating solution due to the presence of ammonia and ethylenediaminetetraacetic acid (EDTA). The catalytic activity tests show that the CHFMR, that does not have the Pd membrane on its outer surface, improves the carbon monoxide (CO) conversion compared with its fixed-bed counterpart. The presence of conical microchannels is expected to enhance the activities of the catalyst in the substrate. The incorporations of Pd and Pd/Ag membranes on the outer layer of ceramic hollow fibres enable pure hydrogen to be produced in the shell-side for both the WGS reaction and the ESR. The CHFMMR is used to remove one of the products enabling the WGS reaction to favour the formation of product. It also facilitates the small amount of catalyst to be used to produce significant amount of hydrogen in the ESR.
The role of CXCR4/SDF-1 and VLA-4/VCAM-1 in migration of bystander-activated T cells: implications for rheumatoid arthritis
Creators: name: Bryant, Jane
Publisher: name: Imperial College London
Year: 2011

description: Bystander lymphocytes generated in vitro by cytokine stimulation (IL-2, IL-6, TNFα) have previously been shown to demonstrate significant identity in phenotype and activation of monocyte signalling pathways to T cells isolated from rheumatoid arthritis (RA) synovial tissue. Tck are a therefore relevant surrogate model for studying the RA T cell. The results presented in this thesis extend previous studies of cytokine- activated T cells (Tck) through phenotypic analysis and determination of migratory responsiveness. Cytokine stimulation upregulated expression of chemokine receptors and integrins on Tck, including CXCR4, VLA-4 and LFA-1. Results of in vitro chemotaxis and extravasation studies revealed that increased expression of CXCR4 and VLA-4 integrin resulted in concentration-dependent Tck migration to their ligands, CXCL12 and VCAM-1, which could be blocked through specific inhibitors and neutralizing antibodies. Increased expression of VLA-4 and LFA-1 also resulted in increased Tck extravasation, inhibited through blockade of VLA-1, LFA-1 or their ligands. Moreover, Tck demonstrated an increased chemotactic response to RA fibroblast- like synoviocytes cultured in vitro, which could be decreased using inhibitors against VLA-4 and CXCR4. The RA/ SCID mouse model was established to assess Tck migratory responsiveness in vivo; however the model did not prove sufficiently robust to definitively determine if the in vitro results reflected the situation in vivo. The activated phenotype of Tck results in increased migratory responsiveness to chemokines and proteins found in the RA synovial joint environment. Tcks elicit proinflammatory cytokine production from monocytes, which was further increased in the migrated Tck subset. Tck also exhibit a phenotype similar to RA synovial tissue T cells, indicating that cytokine activation of T cells could contribute to RA pathogenicity by migration and subsequent cell-cell interactions, perpetuating the inflammatory cascade in RA. The CXCR4/ CXCL12 and VLA-4/ VCAM-1 axes could also potentially be exploited for therapeutic gain in treatment of RA.
Rezension zur Gottesdienst-Ordnung für die Juden im Großherzogthume Sachsen-Weimar-Eisenach, Weimar 1833
Creators: name: (:Unkn) Unknown
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1833
Subjects: subject: 090

description: Laut einer Anmerkung von anderer Hand ist die Rezension 1833 von einem "achtbaren Gelehrten" geschrieben worden; es ist nicht ganz klar, ob damit Zunz gemeint ist oder dieser nur die Abschrift angefertigt hat. Reform des Judentums; Emanzipation der Juden
High performance micro-tubular solid oxide fuel cell
Creators: name: Othman, Mohd Hafiz Dzarfan Bin
Publisher: name: Imperial College London
Year: 2011

description: The development of micro-tubular solid oxide fuel cells (SOFCs) has received more and more attention recently due to a number of advantages of this configuration, such as high volumetric power output and rapid start-up/shut-down. Previously, the fabrication of micro-tubular SOFC was achieved through multiple-step processes, which involves at least one sintering in each step, making the cell fabrication time consuming and costly. For a more economical fabrication of micro-tubular SOFC with more reliability and flexibility in quality control, an advanced dry-jet wet extrusion technique, i.e. a phase inversion-based co-extrusion process, followed by co-sintering and reduction processes has been developed and systematically investigated in this thesis. At the beginning of the study, a dual-layer hollow fibre which consists of a ceriumgadolinium oxide (CGO) electrolyte outer layer of approximately 80 μm supported by an asymmetric nickel (Ni)-CGO anode inner layer, is successfully fabricated using this technique. The resultant cell of the corresponding dual-layer hollow fibre produces the maximum power density of 0.34-0.68 W cm-2 at 550-600 oC. Improvement on the structure of the dual-layer hollow fibres is performed by reducing the electrolyte layer thickness to as thin as 10 μm and the maximum power density of the corresponding cell increases to about 1.11 W cm-2 at 600 oC. However, the value of power density is still slightly lower than what have been previously reported in the literature. One of the major reasons for such lower power output is the less effective porosity in the anode layer of hollow fibres. Therefore, the optimisation on anode porosity of the dual-layer HF is carried out and resulting in the outstanding power output of about 2.32 W cm-2 at 600 oC. This result indeed highlights the advantage of co-extrusion/co-sintering as a fabrication technique in developing high quality micro-tubular SOFC.
A Systematic Review of Survival Rates in R0 Curative Resections after Multiorgan Resection for Locally Advanced Gastric Cancer
Creators: name: Bratosin, Felix
Publisher: name: OSF Registries
Year: 2024
Subjects: subject: Medicine and Health Sciences

description: This systematic review seeks to elucidate the survival outcomes of patients undergoing MVR for LAGC with the intent of achieving R0 resection. By compiling and analyzing data from various studies, this review aims to provide a comprehensive overview of the current evidence on the efficacy of this surgical approach. The review encompasses studies that report on overall survival (OS), disease-free survival (DFS), postoperative morbidity, and mortality rates, offering insights into the benefits and risks associated with MVR in the treatment of LAGC.
title: ADCO, Cartulaire de l'office de la Porte de l'abbaye de Cîteaux, Registrum possessionum porte Cistercii (début XVe siècle), Cart. 172 (11 H 69), 115 folios, f. 0067
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire de l'office de la Porte de l'abbaye de Cîteaux, Registrum possessionum porte Cistercii (début XVe siècle), Archives départementales de la Côte-d'Or, Cart. 172 (11 H 69), 115 folios, f. 0067, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de l'office de la Porte de l'abbaye de Cîteaux, Registrum possessionum porte Cistercii (début XVe siècle), Archives départementales de la Côte-d'Or, Cart. 172 (11 H 69), 115 folios, f. 0067, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Supersymmetric Toda Field Theories
Creators: name: Papadopoulos, G.
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We present new supersymmetric extensions of Conformal Toda and $A^{(1)}_N$ Affine Toda field theories. These new theories are constructed using methods similar to those that have been developed to find supersymmetric extensions of two-dimensional bosonic sigma models with a scalar potential. In particular, we show that the Conformal Toda field theory admits a (1,1)-supersymmetric extension, and the $A^{(1)}_N$ Affine Toda field admits a (1,0)-supersymmetric extension.
description: 13 pages
Two-photon exchange: myth and history
Creators: name: Tomasi-Gustafsson, Egle
name: Pacetti, Simone
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: After recalling the arguments for possible excess of two-photon contribution over $α$-counting, model independent statements about the consequences on the observables will be given. The relevant experimental data are discussed: (polarized and unpolarized) electron and positron elastic scattering on the proton, as well as annihilation data. A reanalysis of unpolarized electron-proton elastic scattering data is presented in terms of the electric to magnetic form factor squared ratio. This observable is in principle more robust against experimental correlations and global normalizations. The present analysis shows indeed that it is a useful quantity that contains reliable and coherent information. The comparison with the ratio extracted from the measurement of the longitudinal to transverse polarization of the recoil proton in polarized electron-proton scattering shows that the results are compatible. These results bring a decisive piece of information in the controversy on the deviation of the proton form factors from the dipole dependence.
description: 12 pages, 5 figures, contribution to NSTAR 2017, to appear in Few Body Systems
Detailed Modelling of Heterogeneous Chemistry on Palladium and Platinum
Creators: name: Bonanni, Michele
Publisher: name: Imperial College London
Year: 2011

description: The investigation presents the development, analysis and iterative validation of a heterogeneous chemical kinetic model for the simulation of reactive hydrocarbon flows over noble metal catalysts. An axisymmetric, two-dimensional boundary layer system is used to model a virtual pore, physically and chemically representative of the average pore through a catalytic bed in short contact time reactors. A mechanism for the modeling of heterogeneous chemistry over palladium was developed by adopting the Unity Bond Index Quadratic Exponential Potential (UBI-QEP) for the calculation of the energetics. This was integrated, where appropriate, with results from ab initio and experimental investigations. The surface mechanism was coupled with a thoroughly validated homogeneous gas mechanism to model the oxidative dehydrogenation of ethane over an alumina supported palladium catalyst (1%Pd/Al2O3). A bimetallic palladium-platinum mechanism was constructed by coupling the palladium chemistry with a platinum mechanism previously developed with the same methodology. The refinement of the mechanism was carried out and validated with experimental measurements of ethane and ethane-acetylene co-feeds over two catalysts (0.2%Pd 3%Pt/Al2O3 and 1%Pd 3%Pt/Al2O3). Extensive investigation of the sensitivity of the model to physical and chemical parameters was undertaken and evaluated in concert with the analysis of modifications to the energetics and chemical kinetic mechanisms. Of particular significance, for the palladium mechanism, was the reduction of the atomic heat of adsorption of carbon on palladium (to 363 kJ/mol). On platinum, evidence of poisoning by acetylene confirmed the indication that an increase in the adsorption energy of acetylene (to 219 kJ/mol) would correct the balance in relative heats of adsorption of key species. The study provides a framework for the construction and development of bimetallic heterogeneous chemical kinetic mechanisms and produces a validated working model for the simulation of reacting flows over pure palladium and bimetallic palladium-platinum catalysts in a range of conditions.
Determing structure-activity relationships between novel pet radiotracers and their non-specific binding properties
Creators: name: Child, Chloe Rose
Publisher: name: Imperial College London
Year: 2012

description: The non-invasive imaging modality positron emission tomography (PET) is used extensively in clinical settings and is increasingly being used by the pharmaceutical industry in drug development. Molecules of biological interest are labelled with positron emitting isotopes e.g. 11C, allowing their biodistribution and kinetics to be followed in vivo. A major factor in the failure of radioligands is the magnitude of unwanted background signal, non-specific binding (NSB) obscuring binding to the desired target. Assumptions have previously been made as to the physiochemical and pharmacological properties of radioligands that can affect NSB. However, little work has been carried out to quantify NSB with regard to determining structure-activity relationships (SARs) in order to optimise efficient radiotracer discovery. Non-specific binding is a poorly understood process but is believed to be related to the non-saturable binding of labelled molecules with tissue membranes. In this work the synthesis of novel radiolabelled molecular libraries has been conducted, their physicochemical properties determined and their non-specific binding measured in vitro using autoradiographical and cell based mass spectrometry assay methods. Structure-activity relationships have been formed between partition coefficient properties, acid dissociation constants, interaction energies and molecular weight in order to determine the effect each of these properties has on non-specific binding. Traditionally lipophilicity, log P, of a radioligand is the main predictor to its non-specific binding properties. However from this work it has been shown that a single physicochemical property cannot be relied on to predict the NSB of a radioligand but multiple properties must be considered.
Dataset for phenomics-enabled genetic dissection of ground cover in wheat
Creators: name: Singh, Daljit
name: Vipin Tomar
name: Wang, Xu
name: Gautam, Yogesh
name: Sandesh Shrestha
name: Kumar, Manish
name: Kumar, Uttam
name: Singh, Ravi Prakash
name: Poland, Jesse
Publisher: name: figshare
Year: 2018
Subjects: subject: 90905 Photogrammetry and Remote Sensing
subject: FOS: Environmental engineering
subject: 70305 Crop and Pasture Improvement (Selection and Breeding)
subject: FOS: Agriculture, forestry and fisheries
subject: 70602 Horticultural Crop Improvement (Selection and Breeding)
subject: 60408 Genomics
subject: FOS: Biological sciences

description: This repository contains digital ground cover data collected at multiple time-points over the large wheat nurseries in South Asia.
Additional file 2 of Identification of key sex-specific pathways and genes in the subcutaneous adipose tissue from pigs using WGCNA method
Creators: name: Wang, Huiyu
name: Wang, Xiaoyi
name: Li, Mingli
name: Wang, Shuyan
name: Chen, Qiang
name: Lu, Shaoxiong
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 2: Table S2.The number of genes in each of the 17 modules.
Historical Archaeological Overview of Nellis Air Force Base Area 2
Creators: name: Stockton, Richard R.
Year: 1994
Subjects: Clark (County)
United States of America (Country)
Las Vegas, Nevada
Nevada (State / Territory)
Nye (County)
Nellis Air Force Base, Nevada
Historic

description: The report presents the results of a cultural resources investigation of Nellis AFB Area 2. The survey that was conducted in May and June of 1993 by Environmental Solutions Inc. identified a range of historic artifacts and features that can serve as the basis for defining a pattern of historic utilization in isolated portions of the Las Vegas Valley and possibly in other desert areas. The field work recorded historic resources that serve as a compliment to written sources.
Class III Cultural Resources Reconnaissance of Drill Hole U19ar on Pahute Mesa, Nye County, Nevada
Creators: name: Reno, Ronald L.
name: Bill, Dennis
name: Myhrer, Keith
name: Lockett, Cari
Year: 1983
Subjects: Clark (County)
United States of America (Country)
Las Vegas, Nevada
Nevada (State / Territory)
Nye (County)
Nellis Air Force Base, Nevada
S062483RR1
S042883RR2
SR062483-1
S042883RR3
S062483RR4
Reconnaissance / Survey

description: Twenty acres surrounding drill hole U19ad were surveyed just north of the existing powerline which is to be rerouted. Much of this area was disturbed by previous testing activity, but the survey (Zerga 1979) demonstrates that archaeological site S042883RR3 did not extend into this area, which is now entirely disturbed.
Projection Based Models for High Dimensional Data
Creators: name: McWilliams, Brian Victor Parulian
Publisher: name: Imperial College London
Year: 2011

description: In recent years, many machine learning applications have arisen which deal with the problem of finding patterns in high dimensional data. Principal component analysis (PCA) has become ubiquitous in this setting. PCA performs dimensionality reduction by estimating latent factors which minimise the reconstruction error between the original data and its low-dimensional projection. We initially consider a situation where influential observations exist within the dataset which have a large, adverse affect on the estimated PCA model. We propose a measure of “predictive influence” to detect these points based on the contribution of each point to the leave-one-out reconstruction error of the model using an analytic PRedicted REsidual Sum of Squares (PRESS) statistic. We then develop a robust alternative to PCA to deal with the presence of influential observations and outliers which minimizes the predictive reconstruction error. In some applications there may be unobserved clusters in the data, for which fitting PCA models to subsets of the data would provide a better fit. This is known as the subspace clustering problem. We develop a novel algorithm for subspace clustering which iteratively fits PCA models to subsets of the data and assigns observations to clusters based on their predictive influence on the reconstruction error. We study the convergence of the algorithm and compare its performance to a number of subspace clustering methods on simulated data and in real applications from computer vision involving clustering object trajectories in video sequences and images of faces. We extend our predictive clustering framework to a setting where two high-dimensional views of data have been obtained. Often, only either clustering or predictive modelling is performed between the views. Instead, we aim to recover clusters which are maximally predictive between the views. In this setting two block partial least squares (TB-PLS) is a useful model. TB-PLS performs dimensionality reduction in both views by estimating latent factors that are highly predictive. We fit TB-PLS models to subsets of data and assign points to clusters based on their predictive influence under each model which is evaluated using a PRESS statistic. We compare our method to state of the art algorithms in real applications in webpage and document clustering and find that our approach to predictive clustering yields superior results. Finally, we propose a method for dynamically tracking multivariate data streams based on PLS. Our method learns a linear regression function from multivariate input and output streaming data in an incremental fashion while also performing dimensionality reduction and variable selection. Moreover, the recursive regression model is able to adapt to sudden changes in the data generating mechanism and also identifies the number of latent factors. We apply our method to the enhanced index tracking problem in computational finance.
Oral history interview with Jim B., 1981
Publisher: name: Columbia University
Year: 2020
Subjects: Drug addicts--United States
Drug dealers--United States
Imprisonment--United States
Drug traffic--History--20th century.--United States
Drug abuse--History--20th century.--United States
Heroin abuse--History--20th century.--United States
Drug addicts--Rehabilitation--United States
Methadone maintenance--History--20th century.--United States

description: In this interview, Jim B. discusses his life in New York, with special attention towards his drug use. He describes how he was first introduced to heroin and how he began dealing it. He discusses how he began using heroin in 1952 in order to lessen his pending jail sentence. He describes how he bribed police in the thirty-second precinct in Manhattan in order to keep his family, who had gotten involved in his drug trafficking, out of jail. He delves into how he sold drugs on Rikers Island while incarcerated. He also describes in great detail the shooting galleries he frequented in the 1950s and 1960s including how and where they operated, and what kind of people they serviced. Jim discusses how he has seen the methadone program change in the ten years he has been a part of it. He remarks on his interest in self improvement and self-education, and describes how he believes it played a role in his survival through his heroin addiction. Jim compares the quality and price of heroin between the 1950s and 1960s. He describes his experience of heroin cravings, and mentions that he would sometimes physically manifest withdrawal symptoms after abstaining from the drug for years. He discusses how he contracted hepatitis twice from heroin injection. Jim also touches on his experience at various drug rehabilitation centers including Serrah and the Morris J. Bernstein Institute
Imaging Hybrid Photon Detectors with Minimized Dead Area and Protection Against Positive Ion Feedback
Creators: name: Ferenc, Daniel
Publisher: name: arXiv
Year: 1998
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: Imaging Hybrid Photon Detectors (HPD) have been developed for integration in large area Cherenkov detectors for high energy physics and astrophysics. The presented designs - developed particularly for the experiments MAGIC, LHCb and AQUA-RICH - comprise very good imaging properties, protection against positive ion feedback and(or) minimum dead area. The underlying innovations are discussed in some detail.
description: 29 pages, 20 figures, submitted to Nucl. Inst. Meth. A
Letter: Tribal letters Regarding Bighorn Sheep Methodology for NTTR
Creators: name: Freeman, Michael A.
Year: 2016
Subjects: Clark (County)
United States of America (Country)
Las Vegas, Nevada
Nevada (State / Territory)
Nye (County)
Nellis Air Force Base, Nevada
Environment Research

description: Tribal letters sent regarding 2016 Bighorn Sheep Methodology for Nevada Test and Training Range (NTTR) Legislative Environmental Impact Statement.
On the N = 2 supersymmetric CP(N) sigma model and Chern Simons terms
Creators: name: Ciuchini, Massimiliano
name: Gracey, J. A.
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We use the large $N$ self consistency method to compute the critical exponents of the fields and coupling of the supersymmetric CP(N) sigma model at leading order in $1/N$ in various dimensions. We verify that the correction to the critical beta-function slope vanishes at O(1/N) which is consistent with supersymmetry. The three dimensional model is investigated explicitly when a Chern Simons term is included supersymmetrically. We determine the modification that this has on the gauge independent quantity β^\prime(g_c) as a function of the Chern Simons coupling, \vartheta. For an N = 2 supersymmetric Chern Simons term the exponent is independent of \vartheta at O(1/N), whilst it is invariant under \vartheta \rightarrow 1/\vartheta when an N = 1 supersymmetric Chern Simons term is included.
description: 24 pages latex, 2 uuencoded figures and 2 uuencoded tables