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title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Development of software for analysis of intracellular calcium homeostasis and contractility of isolated cardiomyocytes
Creators: name: Ð¤Ð¸Ð»Ð¸Ð¿Ð¿Ð¾Ð², Ð®ÑÐ¸Ð¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2021
Subjects: ÐÐ²ÑÐ¾Ð¼Ð°ÑÐ¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐµ ÑÐ¸ÑÑÐµÐ¼Ñ Ð¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ
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description: This work is devoted to the development of software for the analysis of intracellular calcium homeostasis and contractility of isolated cardiomyocytes and its testing on an experimental model of diabetes mellitus. In the course of the work carried out, the following tasks were solved: 1. creation of software that allows simultaneous analysis of the characteristics of spontaneous and induced Ca2+ waves and contractions of isolated cardiomyocytes; 2. software approbation using cells isolated from the hearts of normal rats (control); 3. software approbation using an experimental model of rat diabetes. The research part was conducted on the basis of the Sechenov institute of evolutionary physiology and biochemistry of the Russian academy of sciences (IEFB RAS) in the group of Neuroregulation of muscle function under the guidance of Maxim G. Doretsov, PhD.