cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Synthesis of 1,2,4 oxadiazol-5-imine, 1,2,4-triazol-3-imine and derivatives: a substituted cyanamide-based strategy for heterocycle synthesis
Creators: name: Bhat, Shreesha VA
Publisher: name: University of Lincoln
Year: 2024
Subjects: F151 - Pharmaceutical chemistry

description: Considering the importance of nitrogen-rich heterocycles in drug discovery, a novel strategy towards heterocycle synthesis was envisioned using cyanamide chemistry. Synthesis which involve mild conditions, avoids multi-step sequence and non-toxic reagents are desirable for generation of large combinatorial libraries of drug molecules. We envisaged that the NCN linkage of the cyanamide as well as the concomitant use of the nucleo-and electrophilic centres of the cyanamide could provide a novel synthetic route towards nitrogen heterocycles.The first part (Ch-2) constitute the bulk of the thesis and it focuses on the generation of cyanamide ion and its cyclisative capture with a 1,3-dipole – nitrile oxide in situ. The cycloadduct -1,2,4-oxadiazol-5(4H)-imine was obtained in good yields, which was further transformed into pharmacologically important cores like oxadiazolone and amidines. A library of the different heterocyclic cores was generated, which tolerated a wide variety of functional groups in good to excellent yields.In the second part (Ch-3), we developed a novel protocol for the synthesis of 1,2,4-triazol-3-imine via a formal 1,3-dipolar cycloaddition of in situ generated nitrile imines and cyanamide ion. Further hydrolysis furnished with 1,2,4-triazol-3-one, which is an important core from medicinal chemistry point of view.The concomitant generation and reaction of two reactive species- 1,3-dipoles and cyanamide ion was achieved in a single pot in situ to provide a route towards novel and pharmaceutically important heterocyclic cores. The present work provides a platform for the development of cyanamide derivatives as a ‘single-reagent—diverse-scaffolds’ strategy for time efficient library delivery of structurally diverse molecules.
Correlated Random Measures
Creators: name: Ranganath, Rajesh
name: Blei, David M.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Plant Biology

description: We develop correlated random measures, random measures where the atom weights can exhibit a flexible pattern of dependence, and use them to develop powerful hierarchical Bayesian nonparametric models. Hierarchical Bayesian nonparametric models are usually built from completely random measures, a Poisson-process-based construction in which the atom weights are independent. Completely random measures imply strong independence assumptions in the corresponding hierarchical model, and these assumptions are often misplaced in real-world settings. Correlated random measures address this limitation. They model correlation within the measure by using a Gaussian process in concert with the Poisson process. With correlated random measures, for example, we can develop a latent feature model for which we can infer both the properties of the latent features and their dependency pattern. We develop several other examples as well. We study a correlated random measure model of pairwise count data. We derive an efficient variational inference algorithm and show improved predictive performance on large datasets of documents, web clicks, and electronic health records. Supplementary materials for this article are available online.
Multi-Armed Bandit for Species Discovery: A Bayesian Nonparametric Approach
Creators: name: Battiston, Marco
name: Favaro, Stefano
name: Teh, Yee Whye
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Let (P1, …, PJ) denote J populations of animals from distinct regions. A priori, it is unknown which species are present in each region and what are their corresponding frequencies. Species are shared among populations and each species can be present in more than one region with its frequency varying across populations. In this article, we consider the problem of sequentially sampling these populations to observe the greatest number of different species. We adopt a Bayesian nonparametric approach and endow (P1, …, PJ) with a hierarchical Pitman–Yor process prior. As a consequence of the hierarchical structure, the J unknown discrete probability measures share the same support, that of their common random base measure. Given this prior choice, we propose a sequential rule that, at every time step, given the information available up to that point, selects the population from which to collect the next observation. Rather than picking the population with the highest posterior estimate of producing a new value, the proposed rule includes a Thompson sampling step to better balance the exploration–exploitation trade-off. We also propose an extension of the algorithm to deal with incidence data, where multiple observations are collected in a time period. The performance of the proposed algorithms is assessed through a simulation study and compared to three other strategies. Finally, we compare these algorithms using a dataset of species of trees, collected from different plots in South America. Supplementary materials for this article are available online.
Observations of Channel Change from Constructed Wood Jams on a Forested Gravel-Bed Stream
Creators: name: Flannery, Joel
name: Stubblefield, Andrew
name: Fiori, Rocco
name: Shea, Conor
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Salmonids in the Pacific Northwest face a number of threats: habit degradation, loss of habitat, overharvest, competition from hatchery fish, dams, and climate change. Wood has been shown to play a key role in many aspects of stream habitat quality; however, it is in low supply in many Pacific Northwest streams because of wood removal and timber harvest practices in riparian zones. Wood placement for restoration has the potential to benefit salmonid populations. However, common applications often fall short of producing the physical changes necessary to achieve the objectives, such as the formation of deep pools and cover. This study evaluated the hypothesis that wood jams constructed with whole-tree materials, high wood piece counts, and high wood volumes would be effective at creating instream geomorphic complexity, function, and aquatic habitat quality. Results were based on an evaluation of changes to surface sediment textures and channel morphology at eight constructed wood jams built with varying complexity, wood volumes, and whole-tree materials, including large-diameter trees with an attached rootwad, logs, and branches. We found that complex wood jams created statistically significant changes that include increasing percentage pool cover, increasing scour pool habitat, and sorting and metering gravel, resulting in an increase in the proportion of the stream bed composed of gravels appropriately sized for local species of spawning salmonids, increased habitat heterogeneity, and increased gradient and channel width. Received May 27, 2016; accepted September 1, 2016 Published online December 16, 2016
Synthesis of 1,2,4 oxadiazol-5-imine, 1,2,4-triazol-3-imine and derivatives: a substituted cyanamide-based strategy for heterocycle synthesis
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: F151 - Pharmaceutical chemistry

description: Considering the importance of nitrogen-rich heterocycles in drug discovery, a novel strategy towards heterocycle synthesis was envisioned using cyanamide chemistry. Synthesis which involve mild conditions, avoids multi-step sequence and non-toxic reagents are desirable for generation of large combinatorial libraries of drug molecules. We envisaged that the NCN linkage of the cyanamide as well as the concomitant use of the nucleo-and electrophilic centres of the cyanamide could provide a novel synthetic route towards nitrogen heterocycles.The first part (Ch-2) constitute the bulk of the thesis and it focuses on the generation of cyanamide ion and its cyclisative capture with a 1,3-dipole – nitrile oxide in situ. The cycloadduct -1,2,4-oxadiazol-5(4H)-imine was obtained in good yields, which was further transformed into pharmacologically important cores like oxadiazolone and amidines. A library of the different heterocyclic cores was generated, which tolerated a wide variety of functional groups in good to excellent yields.In the second part (Ch-3), we developed a novel protocol for the synthesis of 1,2,4-triazol-3-imine via a formal 1,3-dipolar cycloaddition of in situ generated nitrile imines and cyanamide ion. Further hydrolysis furnished with 1,2,4-triazol-3-one, which is an important core from medicinal chemistry point of view.The concomitant generation and reaction of two reactive species- 1,3-dipoles and cyanamide ion was achieved in a single pot in situ to provide a route towards novel and pharmaceutically important heterocyclic cores. The present work provides a platform for the development of cyanamide derivatives as a ‘single-reagent—diverse-scaffolds’ strategy for time efficient library delivery of structurally diverse molecules.
Virtual reality video game spectating
Creators: name: Gallacher, Jack Leslie
Publisher: name: University of Lincoln
Year: 2024
Subjects: I100 - Computer science
I140 - Human-computer interaction

description: The effects of wearing a Virtual Reality headset is something that had not been fully investigated due to how new the consumer devices are. Using an Oculus Rift DK2, an accelerometer and adapting past studies by Geri (2002) and LoPresti (2003), a purpose made application was created that studied the effect of a Virtual Reality headset on head movement. While it was found that Virtual Reality headsets do not affect head movement, the process of creating the test application uncovered a potential issue with the Unity game engine where data spikes occur at regular intervals when a stream-reader is used to parse string output from a Python process. As the application provided a base on which to further investigate the effect of Virtual Reality headsets on head movement, the application was made freely available for others to replicate or adapt for use in further research regarding this area.Because there had been no studies that explored viewer preference within Virtual Reality, the second study investigated which camera view was preferred when spectating a Virtual Reality game in Virtual Reality. Using the HTC Vive and several camera angles, it was found that having a first person view of the gameplay is least preferred by spectators whereas having free roam around the game level is the most preferred view. Furthermore, a panning transition between cameras is preferred over an instant switch. Additionally, the level of presence felt in each view, determined by the Spatial Presence Experience Scale (Hartmann et al, 2015) had no effect on spectators preferred view. Although, results suggested a larger study may uncover a significant link. This study also led to the created application being made available for anybody who wished to continue research in this area as it provides a platform to implement and test other Virtual Reality spectator views.
Virtual reality video game spectating
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: I100 - Computer science
I140 - Human-computer interaction

description: The effects of wearing a Virtual Reality headset is something that had not been fully investigated due to how new the consumer devices are. Using an Oculus Rift DK2, an accelerometer and adapting past studies by Geri (2002) and LoPresti (2003), a purpose made application was created that studied the effect of a Virtual Reality headset on head movement. While it was found that Virtual Reality headsets do not affect head movement, the process of creating the test application uncovered a potential issue with the Unity game engine where data spikes occur at regular intervals when a stream-reader is used to parse string output from a Python process. As the application provided a base on which to further investigate the effect of Virtual Reality headsets on head movement, the application was made freely available for others to replicate or adapt for use in further research regarding this area.Because there had been no studies that explored viewer preference within Virtual Reality, the second study investigated which camera view was preferred when spectating a Virtual Reality game in Virtual Reality. Using the HTC Vive and several camera angles, it was found that having a first person view of the gameplay is least preferred by spectators whereas having free roam around the game level is the most preferred view. Furthermore, a panning transition between cameras is preferred over an instant switch. Additionally, the level of presence felt in each view, determined by the Spatial Presence Experience Scale (Hartmann et al, 2015) had no effect on spectators preferred view. Although, results suggested a larger study may uncover a significant link. This study also led to the created application being made available for anybody who wished to continue research in this area as it provides a platform to implement and test other Virtual Reality spectator views.
Design and development of a smart drowning detection system
Creators: name: Zhu, Yujie
Publisher: name: Macquarie University
Year: 2024
Subjects: classificationCode: 400906
subject: Electronic sensors

description: Drowning is a global public health concern, causing an estimated 236,000 deaths in 2019. It is usually the result of inadequate swimming skills, panic, or unattended children. The process of drowning is always quick and silent, and the most effective traditional drowning prevention effort is lifeguard monitoring, but it is costly and less efficient in large areas. There are two primary methods of intelligent drowning detection, including image processing-based systems and sensor-based wearable devices. Sensor-based devices are cost-effective and have high underwater detection capabilities which make them worthy of further development. This thesis proposes two novel wearable devices for drowning prevention: a Smart Wearable Drowning Detector (SWDD) and a Smart Life Vest (SLV). The SWDD consists of a sensing device equipped with multiple sensors and a GPS beacon, which evaluates various parameters to detect drowning, while the GPS beacon will send location data when drowning is detected. Meanwhile, the SLV will deploy via the designed actuator and start inflating automatically to provide buoyancy for the victims. This proposed system achieves timely drowning detection, and real-time localisation, while buying more time for victims to be rescued, which is expected to significantly reduce casualties from drowning.
Giving teachers a voice within the teacher effectiveness paradigm: a mixed methods study focusing on teachers’ perceptions of the impact of their classroom practices on student outcomes in mathematics
Creators: name: Mulligan, Maria McMahon
Publisher: name: University of Lincoln
Year: 2024
Subjects: X300 - Academic studies in education

description: The purpose of this research is to add to the teacher effectiveness research paradigm by furthering understanding about how teachers promote student learning and achievement in mathematics. Across the teacher effectiveness paradigm, there has been a great deal of research that quantitatively measures the value added by teachers to student achievement on standardised tests. However, there is a current under-representation of the voices of teachers about how and why certain factors promote student achievement in mathematics. Therefore, in order to address the complexity of the teaching and learning process, this mixed methods study draws upon secondary TIMSS 2011 data, as well as qualitative interview data from fourth class teachers in Ireland and Northern Ireland. Results from this study highlight qualitative teacher insights as an essential tool for understanding the complex process through which teacher-related factors influence student learning and achievement in mathematics. Several factors which were perceived to promote student achievement on fourth class standardised mathematics tests were revealed. These factors include promoting constant revision of mathematics concepts, engaging in a collaborative staff strategic plan for assessing and addressing student underachievement on standardised tests, communicating a strong positive attitude towards mathematics to students, and holding consecutive years of experience at the same grade level. In addition, teacher insights were instrumental for understanding TIMSS score differences between Ireland and Northern Ireland. These findings suggest that researchers within the teacher effectiveness paradigm, as well as educational policymakers, should recognise teachers as experts regarding the teaching and learning process and include their insights in future studies through use of qualitative methodology. Furthermore, quantitative teacher effectiveness studies should consider including qualitative teacher insights in order to gain a deeper understanding of quantitative findings.
Giving teachers a voice within the teacher effectiveness paradigm: a mixed methods study focusing on teachers’ perceptions of the impact of their classroom practices on student outcomes in mathematics
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: X300 - Academic studies in education

description: The purpose of this research is to add to the teacher effectiveness research paradigm by furthering understanding about how teachers promote student learning and achievement in mathematics. Across the teacher effectiveness paradigm, there has been a great deal of research that quantitatively measures the value added by teachers to student achievement on standardised tests. However, there is a current under-representation of the voices of teachers about how and why certain factors promote student achievement in mathematics. Therefore, in order to address the complexity of the teaching and learning process, this mixed methods study draws upon secondary TIMSS 2011 data, as well as qualitative interview data from fourth class teachers in Ireland and Northern Ireland. Results from this study highlight qualitative teacher insights as an essential tool for understanding the complex process through which teacher-related factors influence student learning and achievement in mathematics. Several factors which were perceived to promote student achievement on fourth class standardised mathematics tests were revealed. These factors include promoting constant revision of mathematics concepts, engaging in a collaborative staff strategic plan for assessing and addressing student underachievement on standardised tests, communicating a strong positive attitude towards mathematics to students, and holding consecutive years of experience at the same grade level. In addition, teacher insights were instrumental for understanding TIMSS score differences between Ireland and Northern Ireland. These findings suggest that researchers within the teacher effectiveness paradigm, as well as educational policymakers, should recognise teachers as experts regarding the teaching and learning process and include their insights in future studies through use of qualitative methodology. Furthermore, quantitative teacher effectiveness studies should consider including qualitative teacher insights in order to gain a deeper understanding of quantitative findings.
Multiple Testing of Submatrices of a Precision Matrix With Applications to Identification of Between Pathway Interactions
Creators: name: Xia, Yin
name: Tianxi Cai
name: T. Tony Cai
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Making accurate inference for gene regulatory networks, including inferring about pathway-by-pathway interactions, is an important and difficult task. Motivated by such genomic applications, we consider multiple testing for conditional dependence between subgroups of variables. Under a Gaussian graphical model framework, the problem is translated into simultaneous testing for a collection of submatrices of a high-dimensional precision matrix with each submatrix summarizing the dependence structure between two subgroups of variables. A novel multiple testing procedure is proposed and both theoretical and numerical properties of the procedure are investigated. Asymptotic null distribution of the test statistic for an individual hypothesis is established and the proposed multiple testing procedure is shown to asymptotically control the false discovery rate (FDR) and false discovery proportion (FDP) at the prespecified level under regularity conditions. Simulations show that the procedure works well in controlling the FDR and has good power in detecting the true interactions. The procedure is applied to a breast cancer gene expression study to identify between pathway interactions. Supplementary materials for this article are available online.
The Spike-and-Slab LASSO
Creators: name: Ročková, Veronika
name: George, Edward I.
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Despite the wide adoption of spike-and-slab methodology for Bayesian variable selection, its potential for penalized likelihood estimation has largely been overlooked. In this article, we bridge this gap by cross-fertilizing these two paradigms with the Spike-and-Slab LASSO procedure for variable selection and parameter estimation in linear regression. We introduce a new class of self-adaptive penalty functions that arise from a fully Bayes spike-and-slab formulation, ultimately moving beyond the separable penalty framework. A virtue of these nonseparable penalties is their ability to borrow strength across coordinates, adapt to ensemble sparsity information and exert multiplicity adjustment. The Spike-and-Slab LASSO procedure harvests efficient coordinate-wise implementations with a path-following scheme for dynamic posterior exploration. We show on simulated data that the fully Bayes penalty mimics oracle performance, providing a viable alternative to cross-validation. We develop theory for the separable and nonseparable variants of the penalty, showing rate-optimality of the global mode as well as optimal posterior concentration when p > n. Supplementary materials for this article are available online.
MyGene2 automated match report: MKS1
Creators: name: Team, The MyGene2
Publisher: name: figshare
Year: 2016
Subjects: subject: 110311 Medical Genetics (excl. Cancer Genetics)
subject: FOS: Basic medicine

description: MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If multiple MyGene2 profiles potentially match on a shared gene of interest, MyGene2 automatically generates a match report summarizing the information in these profiles. This automated match report is shared publicly to help facilitate further research and/or connections between the submitters of the MyGene2 profiles and other interested parties. This is an automated match report for MKS1.
Multiple Testing of Submatrices of a Precision Matrix with Applications to Identification of Between Pathway Interactions
Creators: name: Xia, Yin
name: Tianxi Cai
name: T. Tony Cai
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Making accurate inference for gene regulatory networks, including inferring about pathway by pathway interactions, is an important and difficult task. Motivated by such genomic applications, we consider multiple testing for conditional dependence between subgroups of variables. Under a Gaussian graphical model framework, the problem is translated into simultaneous testing for a collection of submatrices of a high-dimensional precision matrix with each submatrix summarizing the dependence structure between two subgroups of variables. A novel multiple testing procedure is proposed and both theoretical and numerical properties of the procedure are investigated. Asymptotic null distribution of the test statistic for an individual hypothesis is established and the proposed multiple testing procedure is shown to asymptotically control the false discovery rate (FDR) and false discovery proportion (FDP) at the pre-specified level under regularity conditions. Simulations show that the procedure works well in controlling the FDR and has good power in detecting the true interactions. The procedure is applied to a breast cancer gene expression study to identify between pathway interactions.
An exploratory study on educating learners with ASD in primary inclusive setting in Saudi Arabia: issues, attitudes, and challenges
Creators: name: Alzaidi, Faten Abdulhadi
Publisher: name: University of Lincoln
Year: 2024
Subjects: X300 - Academic studies in education
X360 - Academic studies in specialist education

description: The purpose of this research is to facilitate the development and understanding of inclusiveeducation for students with Autism Spectrum Disorder (ASD) in Saudi Arabia. The study islocated within Riyadh, a city in Saudi Arabia. The culture and religion of Saudi society arecentral themes in this study. ASD is a complex disorder due to its characteristics, whichinclude a lack of social skills, communication difficulties, and behaviour problems. A rangeof qualitative methods were adopted; interviews with twenty general education teachers (GT)and special education teachers (SET) as well as participant observation in five schools. Theresearch seeks to identify the attitudes and practices of primary school teachers in terms oftheir support for children in mainstream schools. The study shows that teachers are mostlysupportive and have positive attitudes toward the inclusive education of learners with ASD.The study shows barriers to inclusive education, for example, lack of time, overcrowdedclassrooms, curriculum, attitudes, lack of training, teaching methods and school environmentsand the extent to which mainstream school buildings and classrooms are suitable forinclusion of students with Special Educational Needs (SEN) in general and, more specifically,for students with ASD. Another factor that emerged from the study to support inclusiveeducation was peer tutoring. All the teachers involved in the study are qualified in educationbut they need additional training and knowledge about inclusion and ASD. Finally, the studyprovides some practical recommendations as well as some ideas for future research and otheractivities.
An exploratory study on educating learners with ASD in primary inclusive setting in Saudi Arabia: issues, attitudes, and challenges
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: X300 - Academic studies in education
X360 - Academic studies in specialist education

description: The purpose of this research is to facilitate the development and understanding of inclusiveeducation for students with Autism Spectrum Disorder (ASD) in Saudi Arabia. The study islocated within Riyadh, a city in Saudi Arabia. The culture and religion of Saudi society arecentral themes in this study. ASD is a complex disorder due to its characteristics, whichinclude a lack of social skills, communication difficulties, and behaviour problems. A rangeof qualitative methods were adopted; interviews with twenty general education teachers (GT)and special education teachers (SET) as well as participant observation in five schools. Theresearch seeks to identify the attitudes and practices of primary school teachers in terms oftheir support for children in mainstream schools. The study shows that teachers are mostlysupportive and have positive attitudes toward the inclusive education of learners with ASD.The study shows barriers to inclusive education, for example, lack of time, overcrowdedclassrooms, curriculum, attitudes, lack of training, teaching methods and school environmentsand the extent to which mainstream school buildings and classrooms are suitable forinclusion of students with Special Educational Needs (SEN) in general and, more specifically,for students with ASD. Another factor that emerged from the study to support inclusiveeducation was peer tutoring. All the teachers involved in the study are qualified in educationbut they need additional training and knowledge about inclusion and ASD. Finally, the studyprovides some practical recommendations as well as some ideas for future research and otheractivities.
The role of emotions in initial teacher training in English further education
Creators: name: Hernon-Jarvis, Jane
Publisher: name: University of Lincoln
Year: 2024
Subjects: C811 - Occupational psychology
C812 - Educational psychology
X341 - Academic studies in further education

description: This thesis examines the emerging role of emotional labour in the context of Further Education (FE) colleges in England. These colleges provide Initial Teacher Training (ITT) courses of study for Further Education teachers who are training to become qualified practitioners in the English lifelong learning sector. Using four teacher trainees and four teacher trainers, the thesis explores the nature and scope of how emotional labour can impact on teacher trainees’ learning and the well-being of both teacher trainees and teacher trainers in order to investigate how the insights gleaned would help to develop practice in the field of English ITT in English FE. The findings evidenced that when teaching, a relationship can form. This can be a professional relationship or a relationship that exceeds the boundaries of professionalism.Over a six-month period in 2013/2014 the teacher trainee participants completed an autobiographical life-grid, whilst both trainees and trainers completed a diary and end interview. An exploratory study using two FE colleges and analysis of data using thematic analysis was used to explore the role of emotions in ITT in FE colleges. Two significant findings presented themselves within this thesis. Firstly, the emotional dimensions of a) FE teaching are explored, and b) it is recommended that the support that is given for new teachers in FE in England become an explicit part of the curricula and of staff development in ITT delivery. Secondly, in supporting teaching staff to alleviate the burden of emotional labour, social sharing (i.e. talking about emotional aspects with peers, colleagues) should be encouraged.
The role of emotions in initial teacher training in English further education
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2024
Subjects: C811 - Occupational psychology
C812 - Educational psychology
X341 - Academic studies in further education

description: This thesis examines the emerging role of emotional labour in the context of Further Education (FE) colleges in England. These colleges provide Initial Teacher Training (ITT) courses of study for Further Education teachers who are training to become qualified practitioners in the English lifelong learning sector. Using four teacher trainees and four teacher trainers, the thesis explores the nature and scope of how emotional labour can impact on teacher trainees’ learning and the well-being of both teacher trainees and teacher trainers in order to investigate how the insights gleaned would help to develop practice in the field of English ITT in English FE. The findings evidenced that when teaching, a relationship can form. This can be a professional relationship or a relationship that exceeds the boundaries of professionalism.Over a six-month period in 2013/2014 the teacher trainee participants completed an autobiographical life-grid, whilst both trainees and trainers completed a diary and end interview. An exploratory study using two FE colleges and analysis of data using thematic analysis was used to explore the role of emotions in ITT in FE colleges. Two significant findings presented themselves within this thesis. Firstly, the emotional dimensions of a) FE teaching are explored, and b) it is recommended that the support that is given for new teachers in FE in England become an explicit part of the curricula and of staff development in ITT delivery. Secondly, in supporting teaching staff to alleviate the burden of emotional labour, social sharing (i.e. talking about emotional aspects with peers, colleagues) should be encouraged.
KEF_INV_132559_05
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022

description: Carnet d'inventaire de l'année 1995 (68 pages)
description: Coverage: Kition-Bamboula-Port
title: Recoding Black Mirror Workshop Report 2019
Creators: name: Kanza, Samantha
Publisher: name: University of Southampton
Year: 2019
Subjects: subject: AI3SD, Workshop Report, CPCD, ethical issues, Social Behavior, Artificial Intelligence, Machine Learning, Machine Intelligence

description: The intriguingly named âRe-Coding Black Mirrorâ was a one day workshop at the CPDP Conference (Computers, Privacy & Data Protection) which had three main themes of addressing the Ethical and Societal challenges of digital technologies, considering Computer Science solutions against the misuse of technologies, and Technological approaches to prevent Black Mirrorâs dystopian future. The programme was made up of several sessions of presentations, followed by a group activity to design your own dystopian episode of Black Mirror. These events were all run consecutively so it was possible to attend each talk and take part in the group activities.
Multiple Testing of Submatrices of a Precision Matrix With Applications to Identification of Between Pathway Interactions
Creators: name: Xia, Yin
name: Tianxi Cai
name: T. Tony Cai
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Making accurate inference for gene regulatory networks, including inferring about pathway-by-pathway interactions, is an important and difficult task. Motivated by such genomic applications, we consider multiple testing for conditional dependence between subgroups of variables. Under a Gaussian graphical model framework, the problem is translated into simultaneous testing for a collection of submatrices of a high-dimensional precision matrix with each submatrix summarizing the dependence structure between two subgroups of variables. A novel multiple testing procedure is proposed and both theoretical and numerical properties of the procedure are investigated. Asymptotic null distribution of the test statistic for an individual hypothesis is established and the proposed multiple testing procedure is shown to asymptotically control the false discovery rate (FDR) and false discovery proportion (FDP) at the prespecified level under regularity conditions. Simulations show that the procedure works well in controlling the FDR and has good power in detecting the true interactions. The procedure is applied to a breast cancer gene expression study to identify between pathway interactions. Supplementary materials for this article are available online.
MyGene2 automated match report: OFD1
Creators: name: Team, The MyGene2
Publisher: name: figshare
Year: 2016
Subjects: subject: 110311 Medical Genetics (excl. Cancer Genetics)
subject: FOS: Basic medicine

description: MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If multiple MyGene2 profiles potentially match on a shared gene of interest, MyGene2 automatically generates a match report summarizing the information in these profiles. This automated match report is shared publicly to help facilitate further research and/or connections between the submitters of the MyGene2 profiles and other interested parties. This is an automated match report for OFD1.
The challenge of establishing decomposition functional types to estimate heterotrophic respiration at large scales
Creators: name: Bond-Lamberty, Ben
Publisher: name: figshare
Year: 2016
Subjects: subject: 50102 Ecosystem Function
subject: FOS: Earth and related environmental sciences
subject: 40104 Climate Change Processes

description: Heterotrophic respiration (HR), the aerobic and anaerobic processes mineralizing organic matter, is a key carbon flux but one impossible to measure at large scales. This impedes our ability to understand carbon and nutrient cycles, benchmark models, or reliably upscale point measurements. Given that a new generation of highly mechanistic, genomic-specific global models is not imminent, we suggest that a useful step would be the development of “Decomposition Functional Types” (DFTs). Analogous to established plant functional types (PFTs) and proposed ecosystem functional types, DFTs would abstract and capture important differences in HR metabolism and flux dynamics, allowing modelers and experimentalists to efficiently group and vary these characteristics across space and time. DFTs should be developed using bottom-up, data-driven analyses that will depend heavily on established databases and remote sensing products. We present an example clustering analysis to show how annual HR can be broken into distinct groups associated with global variability in biotic and abiotic factors, and demonstrate that these groups are distinct from (but complementary to) already-existing PFTs. A similar analysis incorporating observational data could form the basis for future DFTs. Finally, we suggest next steps and critical priorities, all critical steps to build a foundation for DFTs in global models, thus providing the ecological and climate change communities with robust, scalable estimates of HR.
MyGene2 automated match report: PKD1
Creators: name: Team, The MyGene2
Publisher: name: figshare
Year: 2016
Subjects: subject: 110311 Medical Genetics (excl. Cancer Genetics)
subject: FOS: Basic medicine

description: MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If multiple MyGene2 profiles potentially match on a shared gene of interest, MyGene2 automatically generates a match report summarizing the information in these profiles. This automated match report is shared publicly to help facilitate further research and/or connections between the submitters of the MyGene2 profiles and other interested parties. This is an automated match report for PKD1.
From Papyrus to Pixels: Optical Character Recognition Applied to Ancient Egyptian Hieratic
Creators: name: Tabin, Julius
Publisher: name: University of Chicago
Year: 2022
Subjects: subject: Hieratic
subject: Ancient Egypt
subject: Middle Kingdom
subject: Middle Egyptian
subject: Optical Character Recognition
subject: Image Deformation Model
subject: Paleography

description: In this thesis, Optical Character Recognition (OCR) was used to investigate the morphology of Middle Egyptian Hieratic, a cursive form of the ancient Egyptian hieroglyphic script used primarily in the ancient Egyptian Middle Kingdom and after. A data set of 13,134 individual hieratic signs was created from existing and new facsimiles and a novel program was developed to analyze them using an Image Deformation Model. It was determined that the program operates with high accuracy, can distinguish separate signs, and can perceive variation from the original texts beyond that of modern facsimiles. When the program was used on large portions of the data, some signs previously thought to be effectively identical have been shown to be morphologically distinct. Also, the “tails” of A1 signs were shown to be largely irrelevant in the analyses, implying that they do not convey significant information. Beyond this, the program was used to answer questions about various well-known texts: it validated the established hypothesis that the Shipwrecked Sailor and Papyrus Prisse were written in the same hand, isolated sign forms unique to the town of Lahun, demonstrated similarities between Papyrus Ebers and the Rhind Papyrus, and determined sign forms unique to Papyrus Westcar. The work provides a starting point for future study in hieratic digital paleography, allowing far more signs to be compared at once than ever before, and offers a free, open-source tool and data set.
Acceptance and Commitment Therapy self-help intervention for depression in haemodialysis patients: a feasibility randomised controlled trial
Creators: name: Vogt, William
Publisher: name: University of Lincoln
Year: 2024
Subjects: C800 - Psychology

description: Objective: People with end-stage renal disease (ESRD) experience high rates of depression and this is associated with poorer health-related outcomes. Acceptance and Commitment Therapy (ACT) has shown promising results in a number of long-termconditions and has been translated into a variety of self-help formats. We aimed to determine the feasibility of a trial examining telephone-supported self-help based on ACT for individuals with ESRD who experience depression. A brief and extended account of theresearch is provided. This is preceded by a systematic literature review examining whether ACT interventions can improve quality of life in long-term physical conditions (see section for more information). Design: A feasibility randomised controlled trial comparing telephone-supported ACT self-help with treatment as usual. Methods: Participants were recruited from four outpatient haemodialysis units acrossNottinghamshire, UK. The Patient Health Questionnaire (PHQ-9), EuroQol (EQ-5D-5L) health-related quality of life measure, Acceptance and Action Questionnaire II (AAQ-II) andValued Living Questionnaire (VLQ) were completed at baseline and 2- and 4-months post-randomisation. Participants in the intervention arm were asked to complete an ACT self-helpmanual over six weeks with weekly telephone support. Following completion of the trial, six participants were interviewed to examine the acceptability of the trial procedure and intervention. Interview data was analysed using framework analysis. Results: In total, 99 (36.87%) of 276 screening questionnaires were returned. Of these, 30 (30.3%) met the cut-off for depression on the PHQ-9 with nine enrolling in the trial. AAQ-II scores of screened participants were positively associated with scores on the PHQ-9 and GAD-7, indicating a positive relationship between psychological inflexibility and distress.Interview data indicated that the recruitment and randomisation procedure, and assessment methods were acceptable. Only one in four of the participants in the ACT arm of the trial completed all chapters of the book with health problems the main barrier to completion. Conclusion: Our findings indicate that a definitive trial examining the effectiveness of a telephone-supported ACT self-help intervention would not be feasible. Many aspects of thetrial were acceptable to participants, including the main recruitment strategy, randomisation procedure and data collection methods. However, low recruitment numbers and poor adherence to the self-help manual indicate that a full-scale trial would not be viable. Factorsthat might account for low recruitment numbers are discussed and personal reflections on the research process are provided.