cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
産業観光イベント「RENEW」と自律的な地域変容のためのデザイン: 内発的発展論およびEzio Manziniの理論をもとに (Factory Tour Event“RENEW”and Design for Autonomous Regional Transformation: Based on Endogenous Development and Ezio Manzini’s Theory)
Creators: name: Mori, Kazuki
Publisher: name: figshare
Year: 2022
Subjects: subject: 120302 Design Innovation
subject: FOS: Arts (arts, history of arts, performing arts, music)
subject: 120508 Urban Design
subject: FOS: Social and economic geography
subject: Design

description: 本稿は「地域の人々が自律的に地域を変容させる状況を後押しするために，私たちはどのよう なデザイン介入ができるか」を問いに掲げ，産業観光イベント「RENEW」の分析を通じて，地 域の内発的な実践を拡大・促進するための関与プロセスの提示を試みるものである.2015 年より 福井県鯖江市・越前市・越前町で開催される「RENEW」は，地域事業所を一斉開放し，工房見 学やワークショップなどを楽しめるイベントだが，6 年間にわたる実践は，参加事業者らによる 約 30 の新規施設の開設などに発展し，地域の変容をもたらしてきた.本稿ではこれを内発的発展 として位置づけ，CoDesignおよびイタリアのデザイン理論家Ezio Manziniの議論を下敷きに考 察することで，地域の人々による内発的な実践をエンパワーする関与の枠組みを抽出した.整理 の結果，「可能空間の可視化」「足場の架設」「実験空間の創出」「参加の促進」の四つのプロセス からなる「内発的実践のエンパワメント」のモデルを提示し，地域へのデザイン介入を通じて， 地域の人々の主体的な参加・実践による地域変容の実現が可能であることを示した.
 (This paper is an attempt to articulate a design intervention process, based on a case analysis, to enhance a regional transformation led by local inhabitants. Having been held in Sabae City, Echizen City, and Echizen Town since 2015, RENEW is an industrial tourism event in which local businesses open their studios and factories to the public for guided tours, workshops and more. This annual event has resulted in approximately 30 new shops, inns, galleries, and factories being opened by participating local companies, which has changed the landscape and culture of the region. By analysing this movement, underpinned by Tsurumi’s endogenous development theory and by Ezio Manzini’s design for social innovation theory, I propose a model called “empowerment for endogenous practice”. This model consists of four processes: visualisation of the possible space, scaffolding, the creation of the experimental space, and the promotion of participation. In addition, it can enable regional transformation through local residents’ participation and utilisation. * This English abstract is not peer-reviewed)
産業観光イベント「RENEW」と自律的な地域変容のためのデザイン: 内発的発展論およびEzio Manziniの理論をもとに (Factory Tour Event“RENEW”and Design for Autonomous Regional Transformation: Based on Endogenous Development and Ezio Manzini’s Theory)
Creators: name: Mori, Kazuki
Publisher: name: figshare
Year: 2022
Subjects: subject: 120302 Design Innovation
subject: FOS: Arts (arts, history of arts, performing arts, music)
subject: 120508 Urban Design
subject: FOS: Social and economic geography
subject: Design

description: 本稿は「地域の人々が自律的に地域を変容させる状況を後押しするために，私たちはどのよう なデザイン介入ができるか」を問いに掲げ，産業観光イベント「RENEW」の分析を通じて，地 域の内発的な実践を拡大・促進するための関与プロセスの提示を試みるものである.2015 年より 福井県鯖江市・越前市・越前町で開催される「RENEW」は，地域事業所を一斉開放し，工房見 学やワークショップなどを楽しめるイベントだが，6 年間にわたる実践は，参加事業者らによる 約 30 の新規施設の開設などに発展し，地域の変容をもたらしてきた.本稿ではこれを内発的発展 として位置づけ，CoDesignおよびイタリアのデザイン理論家Ezio Manziniの議論を下敷きに考 察することで，地域の人々による内発的な実践をエンパワーする関与の枠組みを抽出した.整理 の結果，「可能空間の可視化」「足場の架設」「実験空間の創出」「参加の促進」の四つのプロセス からなる「内発的実践のエンパワメント」のモデルを提示し，地域へのデザイン介入を通じて， 地域の人々の主体的な参加・実践による地域変容の実現が可能であることを示した. (This paper is an attempt to articulate a design intervention process, based on a case analysis, to enhance a regional transformation led by local inhabitants. Having been held in Sabae City, Echizen City, and Echizen Town since 2015, RENEW is an industrial tourism event in which local businesses open their studios and factories to the public for guided tours, workshops and more. This annual event has resulted in approximately 30 new shops, inns, galleries, and factories being opened by participating local companies, which has changed the landscape and culture of the region. By analysing this movement, underpinned by Tsurumi’s endogenous development theory and by Ezio Manzini’s design for social innovation theory, I propose a model called “empowerment for endogenous practice”. This model consists of four processes: visualisation of the possible space, scaffolding, the creation of the experimental space, and the promotion of participation. In addition, it can enable regional transformation through local residents’ participation and utilisation. * This English abstract is not peer-reviewed) https://www.fpu.ac.jp/rire/publication/regular/d154339.html
Measurement of the Z boson invisible width at $\sqrt{s}=13$ TeV with the ATLAS detector
Creators: name: ATLAS Collaboration
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: A measurement of the invisible width of the $Z$ boson using events with jets and missing transverse momentum is presented using 37 $\mbox{fb\(^{-1}\)}$ of 13 TeV proton-proton data collected by the ATLAS detector in 2015 and 2016. The ratio of $Z\rightarrow \textrm{inv}$ to $Z\rightarrow\ell\ell$ events, where inv refers to non-detected particles and $\ell$ is either an electron or a muon, is measured and corrected for detector effects. Events with at least one energetic central jet with $p_{\textrm{T}} \geq 110$ GeV are selected for both the $Z\rightarrow \textrm{inv}$ and $Z\rightarrow\ell\ell$ final states to obtain a similar phase space in the ratio. The invisible width is measured to be $506\pm2 \textrm{ (stat.)} \pm12 \textrm{ (syst.)}$ MeV and is the single most precise recoil-based measurement. The result is in agreement with the most precise determination from LEP and the Standard Model prediction based on three neutrino generations.
description: 41 pages in total, author list starting page 24, 7 figures, 1 table, published in Phys. Lett. B 854 (2024) 138705. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2019-01
Multipole expansion at the level of the action in $d$-dimensions
Creators: name: Amalberti, Loris
name: Larrouturou, François
name: Yang, Zixin
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this paper we study the multipole expansion of the long-wavelength effective action for radiative sources in ($d$+1) spacetime dimensions. We present detailed expressions for the multipole moments for the case of scalar-, electromagnetic-, and (linearized) gravitational-wave emission. For electromagnetism and gravity, we derive expressions for the odd-parity, magnetic-type moments as SO($d$) duals of the ones traditionally used in the literature. The $d$-dimensional case features a novel set of `Weyl-type' moments, coupling to the spatial part of the Weyl tensor, which are absent in three dimensions. Agreement is found in the overlap with previous known results, notably in the $d \to 3$ limit. Due to its reliance on dimensional regularization, the results presented here play a crucial role for the further development of the Effective Field Theory approach to gravitational dynamics, and in particular for the computation of the gravitational-wave flux, starting at the third post-Newtonian order.
description: 26 pages, v2: typos corrected, published version
title: Schacht der Verlorenen
Creators: name: Parein, René
name: Club Spéléo Furets Jaunes De Seyssins
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Topographie de la cavité Schacht der Verlorenen ; Profondeur : - 724 m ; géomorphologie ; toponymie ; Coupe complète ; coupe developpée ; [Echelle : 1/1000]
description: Coverage: Europe
description: Coverage: Autriche
description: Coverage: Salzburg
description: Provenance: Don Christophe Gauchon
BAX channel activity mediates lysosomal disruption linked to Parkinson disease
Creators: name: Bové, Jordi
name: Martínez-Vicente, Marta
name: Dehay, Benjamin
name: Celine Perier
name: Recasens, Ariadna
name: Bombrun, Agnes
name: Antonsson, Bruno
name: Vila, Miquel
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Earth and Environmental Sciences
subject: Neuroscience
subject: Molecular Biology
subject: Cell Biology
subject: Medicine
subject: Biochemistry

description: Lysosomal disruption is increasingly regarded as a major pathogenic event in Parkinson disease (PD). A reduced number of intraneuronal lysosomes, decreased levels of lysosomal-associated proteins and accumulation of undegraded autophagosomes (AP) are observed in PD-derived samples, including fibroblasts, induced pluripotent stem cell-derived dopaminergic neurons, and post-mortem brain tissue. Mechanistic studies in toxic and genetic rodent PD models attribute PD-related lysosomal breakdown to abnormal lysosomal membrane permeabilization (LMP). However, the molecular mechanisms underlying PD-linked LMP and subsequent lysosomal defects remain virtually unknown, thereby precluding their potential therapeutic targeting. Here we show that the pro-apoptotic protein BAX (BCL2-associated X protein), which permeabilizes mitochondrial membranes in PD models and is activated in PD patients, translocates and internalizes into lysosomal membranes early following treatment with the parkinsonian neurotoxin MPTP, both in vitro and in vivo, within a time-frame correlating with LMP, lysosomal disruption, and autophagosome accumulation and preceding mitochondrial permeabilization and dopaminergic neurodegeneration. Supporting a direct permeabilizing effect of BAX on lysosomal membranes, recombinant BAX is able to induce LMP in purified mouse brain lysosomes and the latter can be prevented by pharmacological blockade of BAX channel activity. Furthermore, pharmacological BAX channel inhibition is able to prevent LMP, restore lysosomal levels, reverse AP accumulation, and attenuate mitochondrial permeabilization and overall nigrostriatal degeneration caused by MPTP, both in vitro and in vivo. Overall, our results reveal that PD-linked lysosomal impairment relies on BAX-induced LMP, and point to small molecules able to block BAX channel activity as potentially beneficial to attenuate both lysosomal defects and neurodegeneration occurring in PD.
NK Cell Mediated Recognition and Killing of HIV-Infected Macrophages
Creators: name: KEK, HANS
Publisher: name: Monash University
Year: 2024
Subjects: classificationCode: 320404
subject: Cellular immunology
classificationCode: 320407
subject: Innate immunity
classificationCode: 320211
subject: Infectious diseases
classificationCode: 310706
subject: Virology

description: HIV can infect a type of immune cell called macrophages, which persists in people with HIV despite anti-HIV therapy. These cells are a barrier to HIV cure, however, not much is known about how we can eliminate them. This thesis identified anti-HIV antibodies that can target HIV-infected macrophages and developed a modified anti-HIV antibody that can enhance immune killing of them. It also identified types of immune cells called natural killer cells that can effectively target HIV-infected macrophages. These natural killer cells may be used together with anti-HIV antibodies as part of an HIV cure immunotherapy in the future for people living with HIV.
Involvement of autophagy in hypoxic-excitotoxic neuronal death
Creators: name: Ginet, Vanessa
name: Luthi-Carter, Ruth
name: Puyal, Julien
name: Spiehlmann, Amélie
name: Rummel, Coralie
name: Rudinskiy, Nikita
name: Grishchuk, Yulia
name: Clarke, Peter GH
name: Truttmann, Anita C
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Earth and Environmental Sciences
subject: Physiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Molecular Biology
subject: Cell Biology
subject: Microbiology
subject: Medicine
subject: Biochemistry

description: Neuronal autophagy is increased in numerous excitotoxic conditions including neonatal cerebral hypoxia-ischemia (HI). However, the role of this HI-induced autophagy remains unclear. To clarify this role we established an in vitro model of excitotoxicity combining kainate treatment (Ka, 30 µM) with hypoxia (Hx, 6% oxygen) in primary neuron cultures. KaHx rapidly induced excitotoxic death that was completely prevented by MK801 or EGTA. KaHx also stimulated neuronal autophagic flux as shown by a rise in autophagosome number (increased levels of LC3-II and punctate LC3 labeling) accompanied by increases in lysosomal abundance and activity (increased SQSTM1/p62 degradation, and increased LC3-II levels in the presence of lysosomal inhibitors) and fusion (shown using an RFP-GFP-LC3 reporter). To determine the role of the enhanced autophagy we applied either pharmacological autophagy inhibitors (3-methyladenine or pepstatinA/E64) or lentiviral vectors delivering shRNAs targeting Becn1 or Atg7. Both strategies reduced KaHx-induced neuronal death. A prodeath role of autophagy was also confirmed by the enhanced toxicity of KaHx in cultures overexpressing BECN1 or ATG7. Finally, in vivo inhibition of autophagy by intrastriatal injection of a lentiviral vector expressing a Becn1-targeting shRNA increased the volume of intact striatum in a rat model of severe neonatal cerebral HI. These results clearly show a death-mediating role of autophagy in hypoxic-excitotoxic conditions and suggest that inhibition of autophagy should be considered as a neuroprotective strategy in HI brain injuries.
Mori_Factory_Tour_Event_RENEW_and_Design_for_Autonomous_Regional_Transformation.pdf
Creators: name: Mori, Kazuki
Publisher: name: figshare
Year: 2022
Subjects: subject: 120302 Design Innovation
subject: FOS: Arts (arts, history of arts, performing arts, music)
subject: 120508 Urban Design
subject: FOS: Social and economic geography
subject: Design

description: 本稿は「地域の人々が自律的に地域を変容させる状況を後押しするために，私たちはどのよう なデザイン介入ができるか」を問いに掲げ，産業観光イベント「RENEW」の分析を通じて，地 域の内発的な実践を拡大・促進するための関与プロセスの提示を試みるものである.2015 年より 福井県鯖江市・越前市・越前町で開催される「RENEW」は，地域事業所を一斉開放し，工房見 学やワークショップなどを楽しめるイベントだが，6 年間にわたる実践は，参加事業者らによる 約 30 の新規施設の開設などに発展し，地域の変容をもたらしてきた.本稿ではこれを内発的発展 として位置づけ，CoDesignおよびイタリアのデザイン理論家Ezio Manziniの議論を下敷きに考 察することで，地域の人々による内発的な実践をエンパワーする関与の枠組みを抽出した.整理 の結果，「可能空間の可視化」「足場の架設」「実験空間の創出」「参加の促進」の四つのプロセス からなる「内発的実践のエンパワメント」のモデルを提示し，地域へのデザイン介入を通じて， 地域の人々の主体的な参加・実践による地域変容の実現が可能であることを示した.
 (This paper is an attempt to articulate a design intervention process, based on a case analysis, to enhance a regional transformation led by local inhabitants. Having been held in Sabae City, Echizen City, and Echizen Town since 2015, RENEW is an industrial tourism event in which local businesses open their studios and factories to the public for guided tours, workshops and more. This annual event has resulted in approximately 30 new shops, inns, galleries, and factories being opened by participating local companies, which has changed the landscape and culture of the region. By analysing this movement, underpinned by Tsurumi’s endogenous development theory and by Ezio Manzini’s design for social innovation theory, I propose a model called “empowerment for endogenous practice”. This model consists of four processes: visualisation of the possible space, scaffolding, the creation of the experimental space, and the promotion of participation. In addition, it can enable regional transformation through local residents’ participation and utilisation. * This English abstract is not peer-reviewed) https://www.fpu.ac.jp/rire/publication/regular/d154339.html
title: Beyond Words:Engaging young children and families in gallery education
Creators: name: Wright, D
Publisher: name: Liverpool John Moores University
Year: 2020

description: Beyond Words: Engaging Young Children and Families in Gallery Education at Tate Liverpool, is a three year ethnographic case study that explores what happens when preschool children, parents and nursery practitioners from a Sure Start Children’s Centre, visit Tate to participate in an extended series of gallery visits and workshops with artists. This study explores the potential value and tensions of these creative and cultural experiences, particularly for young children and families, by critically examining different perspectives, discourses and possible constructs of effective creative engagement. A theoretical bricolage is used for presenting various insights into the relationship between exploratory creative processes, children’s artistic flow, experiential learning and matters of inclusion. Bringing structuralist theories of learning together with non-representational theories, this study draws on Reggio Emilia, Deweyan and Deleuzian philosophies for thinking about children’s learning in art galleries. In doing so, it makes a case for new materialist and posthuman discourses to be considered alongside cognitive, linguistic and social constructivist pedagogies. This PhD study also contributes to debates on involving young children and families from marginalised communities in cultural visits and creative practices by opening up existing discussions on poverty and negative stereotypes. It also argues for a more creative, democratic and process driven education for young children which does not sit comfortably within current structures of formal teacher-led education, and therefore requires a messier, unbounded and rhizomatic way of thinking.
Effective mass and field-reinforced superconductivity in uranium compounds
Creators: name: Mineev, V. P.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: A theory of strong coupling superconductivity in uranium compounds has been developed, based on electron-electron interaction through magnetic fluctuations described by frequency-dependent magnetic susceptibility. The magnetic field dependence of the electron effective mass is expressed through the field dependence of the magnetic susceptibility components. It is shown that the intensity of triplet pairing, and hence the critical temperature of the transition to the superconducting state, is also determined by the field-dependent susceptibility. The results are discussed in relation to the properties of ferromagnetic uranium compounds URhGe and UCoGe, as well as the recently discovered UTe2.
description: 21 pages
Identification of autophagy as a longevity-assurance mechanism in the aging model Podospora anserina
Creators: name: Hamann, Andrea
name: Knuppertz, Laura
name: Pampaloni, Francesco
name: Stelzer, Ernst
name: Osiewacz, Heinz D
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Biological Sciences
subject: Ecology
subject: Earth and Environmental Sciences
subject: Physiology
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Biochemistry

description: The filamentous ascomycete Podospora anserina is a well-established aging model in which a variety of different pathways, including those involved in the control of respiration, ROS generation and scavenging, DNA maintenance, proteostasis, mitochondrial dynamics, and programmed cell death have previously been demonstrated to affect aging and life span. Here we address a potential role of autophagy. We provide data demonstrating high basal autophagy levels even in strains cultivated under noninduced conditions. By monitoring an N-terminal fusion of EGFP to the fungal LC3 homolog PaATG8 over the lifetime of the fungus on medium with and without nitrogen supplementation, respectively, we identified a significant increase of GFP puncta in older and in nitrogen-starved cultures suggesting an induction of autophagy during aging. This conclusion is supported by the demonstration of an age-related and autophagy-dependent degradation of a PaSOD1-GFP reporter protein. The deletion of Paatg1, which leads to the lack of the PaATG1 serine/threonine kinase active in early stages of autophagy induction, impairs ascospore germination and development and shortens life span. Under nitrogen-depleted conditions, life span of the wild type is increased almost 4-fold. In contrast, this effect is annihilated in the Paatg1 deletion strain, suggesting that the ability to induce autophagy is beneficial for this fungus. Collectively, our data identify autophagy as a longevity-assurance mechanism in P. anserina and as another surveillance pathway in the complex network of pathways affecting aging and development. These findings provide perspectives for the elucidation of the mechanisms involved in the regulation of individual pathways and their interactions.
Macrophage dynamics in muscle regeneration and wound resolution
Creators: name: MANNEKEN, JESSICA DANIELLE
Publisher: name: Monash University
Year: 2024
Subjects: classificationCode: 320606
subject: Regenerative medicine (incl. stem cells)

description: This thesis examines the behaviours and dynamics of an innate immune cell type, the macrophage, during muscle repair. Specifically, this thesis focuses on dissecting the direct interactions of macrophages and muscle progenitor cells and identifies potential mechanisms for how macrophages influence the behaviour of muscle progenitor cells.
OʻZBEK, RUS VA QORAQALPOQ TILLARIDA SON SO'Z TURKUMI
Creators: name: Usanova, Qademay
name: Xudayarova, M.
Publisher: name: Zenodo
Year: 2024

description: Mazkur maqolada o‘zbek, rus va qoraqalpoq tillarida son so‘z turkumining qiyosi, sintaktik vazifalari, o‘xshash va farqli tomonlari tadqiq etildi.
LOCAL HISTORY AS TEACHERS' CURRICULAR SPACE FOR PROMOTING CITIZENSHIP EDUCATION IN THAI PUBLIC SCHOOLS
Creators: name: Wasan Sapphasuk
Publisher: name: National Research Council of Thailand
Year: 2020
Subjects: Social studies
Local history
Citizenship education
Curricular space

description: Official Journal of National Research Council of Thailand In conjunction with the International Journal of Multiculturalism and Education, 6, 1, 13-26
title: Entrepreneurial Marketing as a Way for Chinese SMEs to Operate Effectively in a Transition Economy
Creators: name: Chen, M
Publisher: name: Liverpool John Moores University
Year: 2020

description: Entrepreneurial marketing is both a theoretical and practical construct at the interface between entrepreneurship and marketing, with a relatively long existence, but insufficiently developed in theoretical terms. Most evidence of effective EM practice is Western in nature. Little attempt has been made to explore entrepreneurial marketing in transition economies, such as China. This research builds on the limited work to date on the practical aspect of the role of EM in a transition economy, China. The findings of this research are generated from qualitative research through in-depth interviews and participant observation. To investigate the role of EM among Chinese SMEs, Morris et al. (2002)’s seven dimensions framework is applied. The findings show that all dimensions of EM have been internalised and applied effectively in marketing activities among Chinese SMEs with promising results. The results also confirm a positive link between the core EM elements (including networking, word of mouth marketing, creativity) and Chinese SMEs’ performance. EM provides Chinese SMEs with new opportunities in overcoming obstacles posed by certain limitations, such as constrains in business financing, underdeveloped free market, industry barriers, and so on. While traditional marketing is causal logic-based, EM decision-making tends to be effectual. Through using Sarasvathy (2009)’s principles of effectuation, this research assessed the part played by Chinese entrepreneurs in shaping a business venture. The findings show that all participant Chinese entrepreneurs had applied effectuation logic in their decision-making, especially when they first started their businesses. Chinese entrepreneurs display sufficient signs of effectuation reasoning and play an essential role in shaping a new business venture. The finding also confirms that all dimensions of EM and principles of effectuation are not independent; instead, they can all be regarded as complementary elements. Chinese SMEs share EM and effectuation elements such as relying on networking, relationship building, adopting a bottom-up approach, use resources at hand, use creative ways to leverage limited resources, achieve control of the future, and so on. Being more entrepreneurial in marketing, employing both entrepreneurial orientation and market orientation as well as applying effectual decision making help Chinese SMEs to operate effectively in the turbulent business environment.
title: Préface_Des œufs en abondance, à la ferme, chez l'amateur
Creators: name: AmateurS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021

description: Préface
description: ID_PARA_01021
On the Potential of Image Similarity Metrics for Comparing Phase Center Corrections
Creators: name: Kröger, Johannes
name: Kersten, Tobias
name: Breva, Yannick
name: Schön, Steffen
Publisher: name: Berlin ; Heidelberg : Springer
Year: 2022
Subjects: subject: Image similarity metrics
subject: Multi-GNSS processing
subject: Phase center corrections
subject: Singular value decomposition
subject: Konferenzschrift
subject: Dewey Decimal Classification::500 | Naturwissenschaften::550 | Geowissenschaften

description: For highly precise and accurate positioning and navigation with Global Navigation Satellite Systems (GNSS), it is mandatory to take phase center corrections (PCC) into account. These corrections are provided by different calibration facilities and methods. Currently, discussions in the framework of the International GNSS Service (IGS) antenna working group (AWG) are ongoing on how to accept new calibration facilities as an official IGS calibration facility. In this paper, different image similarity measures and their potential for comparing PCC are presented. Currently used comparison strategies are discussed and their performance is illustrated with several geodetic antennas. We show that correlation coefficients are an appropriate measure to compare different sets of PCC since they perform independently of a constant part within the patterns. However, feature detection algorithms like the Speeded-Up Robust Features (SURF) mostly do not find distinctive structures within the PCC differences due to the smooth character of PCC. Therefore, they are inapplicable for comparing PCC. Singular Value Decomposition (SVD) of PCC differences (ΔPCC) can be used to analyse which structures ΔPCC are composed of. We show that characteristic structures can be found within ΔPCC. Therefore, the SVD is a promising tool to analyse the impact of PCC differences in the coordinate domain.
The Use of Medicinal Marijuana for Treating Cerebral Palsy: A Systematic Review
Creators: name: Shaw, Trent
name: Charles, James
name: J. McDonough, Daniel
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 420899
subject: Traditional, complementary and integrative medicine not elsewhere classified
classificationCode: 420106
subject: Physiotherapy
classificationCode: 420199
subject: Allied health and rehabilitation science not elsewhere classified

description: This is a systematic literature review to explore MM interventions globally with a focus on MM treatment of symptoms and conditions associated with adult CP patients, including spasticity, pain, sleep, QOL, and SEWB.
Bounding the Residual Tropospheric Error by Interval Analysis
Creators: name: Su, Jingyao
name: Schön, Steffen
Publisher: name: Berlin ; Heidelberg : Springer
Year: 2022
Subjects: subject: Error bounding
subject: Global navigation satellite systems
subject: Integrity
subject: Interval analysis
subject: Residual tropospheric error
subject: Konferenzschrift
subject: Dewey Decimal Classification::500 | Naturwissenschaften::550 | Geowissenschaften

description: GNSS integrity monitoring requires proper bounding to characterize all ranging error sources. Unlike classical approaches based on probabilistic assumptions, our alternative integrity approach depends on deterministic interval bounds as inputs. The intrinsically linear uncertainty propagation with intervals is adequate to describe remaining systematic uncertainty, the so-called imprecision. In this contribution, we make a proposal on how to derive the required intervals in order to quantify and bound the residual error for empirical troposphere models, based on the refined sensitivity analysis via interval arithmetic. We evaluated experimentally the Saastamoinen model with (i) a priori ISO standard atmosphere, and (ii) on-site meteorological measurements from IGS and Deutscher Wetterdienst (DWD) stations as inputs. We obtain consistent and complete enclosure of residual ZPD errors w.r.t IGS ZPD products. Thanks to the DWD dense network, interval maps for meteorological parameters and residual ZPD errors are generated for Germany as by-products. These experimental results and products are finally validated, taking advantage of the high-quality tropospheric delays estimated by the Vienna Ray Tracer. Overall, the results indicate that our strategy based on interval analysis successfully bounds tropospheric model uncertainty. This will contribute to a realistic uncertainty assessment of GNSS-based single point positioning.
Ozone exposure and systemic biomarkers: Evaluation of evidence for adverse cardiovascular health impacts
Creators: name: Sax, Sonja N.
name: Goodman, Julie E.
name: Prueitt, Robyn L.
name: Pizzurro, Daniella M.
name: Lynch, Heather N.
name: Zu, Ke
name: Venditti, Ferdinand J.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Earth and Environmental Sciences
Biotechnology
Cell Biology
Medicine

description: The US Environmental Protection Agency (EPA) recently concluded that there is likely to be a causal relationship between short-term (< 30 days) ozone exposure and cardiovascular (CV) effects; however, biological mechanisms to link transient effects with chronic cardiovascular disease (CVD) have not been established. Some studies assessed changes in circulating levels of biomarkers associated with inflammation, oxidative stress, coagulation, vasoreactivity, lipidology, and glucose metabolism after ozone exposure to elucidate a biological mechanism. We conducted a weight-of-evidence (WoE) analysis to determine if there is evidence supporting an association between changes in these biomarkers and short-term ozone exposure that would indicate a biological mechanism for CVD below the ozone National Ambient Air Quality Standard (NAAQS) of 75 parts per billion (ppb). Epidemiology findings were mixed for all biomarker categories, with only a few studies reporting statistically significant changes and with no consistency in the direction of the reported effects. Controlled human exposure studies of 2 to 5 hours conducted at ozone concentrations above 75 ppb reported small elevations in biomarkers for inflammation and oxidative stress that were of uncertain clinical relevance. Experimental animal studies reported more consistent results among certain biomarkers, although these were also conducted at ozone exposures well above 75 ppb and provided limited information on ozone exposure-response relationships. Overall, the current WoE does not provide a convincing case for a causal relationship between short-term ozone exposure below the NAAQS and adverse changes in levels of biomarkers within and across categories, but, because of study limitations, they cannot not provide definitive evidence of a lack of causation.
An update to the toxicological profile for water-soluble and sparingly soluble tungsten substances
Creators: name: Ranulfo Lemus
name: Venezia, Carmen F.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Science Policy
Biological Sciences
Chemistry
Earth and Environmental Sciences
Medicine

description: Tungsten is a relatively rare metal with numerous applications, most notably in machine tools, catalysts, and superalloys. In 2003, tungsten was nominated for study under the National Toxicology Program, and in 2011, it was nominated for human health assessment under the US Environmental Protection Agency's (EPA) Integrated Risk Information System. In 2005, the Agency for Toxic Substances and Disease Registry (ATSDR) issued a toxicological profile for tungsten, identifying several data gaps in the hazard assessment of tungsten. By filling the data gaps identified by the ATSDR, this review serves as an update to the toxicological profile for tungsten and tungsten substances. A PubMed literature search was conducted to identify reports published during the period 2004–2014, in order to gather relevant information related to tungsten toxicity. Additional information was also obtained directly from unpublished studies from within the tungsten industry. A systematic approach to evaluate the quality of data was conducted according to published criteria. This comprehensive review has gathered new toxicokinetic information and summarizes the details of acute and repeated-exposure studies that include reproductive, developmental, neurotoxicological, and immunotoxicological endpoints. Such new evidence involves several relevant studies that must be considered when regulators estimate and propose a tungsten reference or concentration dose.
title: Ein Beitrag zur Instandhaltung von Brandschutzmaßnahmen in Immobilien
Creators: name: Seeger, Arndt-Philipp C.
Publisher: name: UNSPECIFIED
Year: 2025

description: Die vorliegende Dissertation befasst sich mit der Instandhaltung von Brandschutzmaßnahmen während des längsten Abschnitts im Lebenszyklus von Immobilien: der Nutzungsphase. Ausgangspunkt ist unter anderem die hohe Mängelquote bei wiederkehrenden Prüfungen von Brandschutzeinrichtungen. Diese Mängel gefährden nicht nur die Sicherheit von Personen, Sachwerten und der Umwelt, sondern können auch erhebliche rechtliche und finanzielle Konsequenzen für Immobilieneigentümer*innen nach sich ziehen. Vor diesem Hintergrund liefert die vorliegende Arbeit eine Analyse von Schlüsselprozessen der Instandhaltung von Brandschutzmaßnahmen und baut dabei auf den Grundlagen des baulichen Brandschutzes auf. Diese bestehen aus den grundlegenden Anforderungen an bauliche, technische und organisatorische Brandschutzmaßnahmen, der Verankerung des Brandschutzes im Lebenszyklus einer Immobilie sowie der Betrachtung der Instandhaltung. Im Zuge der Untersuchung wurden die Aspekte des Immobilienübergangs, verschiedene Soll- und Ist-Zustände sowie die Betreiberverantwortung erarbeitet. Darauf aufbauend erfolgte die Entwicklung eines Prozessmodells, das durch eine systematische Betrachtung, Strukturierung und Priorisierung der relevanten Abläufe aus der Perspektive von Immobilieneigentümer*innen die notwendigen Prozesse der Instandhaltung abbildet. Der Fokus liegt dabei auf der Einordnung in das polyzyklische Lebenszyklusmodell von Immobilien, wobei das Prozessmodell aus drei zentralen Ketten besteht: der Integrationsphase, der Instandhaltungsphase und der Mängelbeseitigung. Weiter ist die Dokumentation der Instandhaltung von zentraler Bedeutung innerhalb des Modells und für die Instandhaltung an sich. Anhand dieser erfolgt die Prüfung der Instandhaltung, sowohl intern als auch durch die Behörden. Ebenfalls findet über die Rückkopplung mit der Unternehmensstrategie die geplante Verwendung einer Immobilie durch den Eigentümer bzw. die Eigentümerin Eingang in die Instandhaltung. Insgesamt wird ein Beitrag zur Praxis des Immobilienmanagements geleistet, indem ein ganzheitlicher und methodisch fundierter Ansatz für die Instandhaltung von Brandschutzmaßnahmen entwickelt wird.
Estimation and Validation of Codephase Center Correction Using the Empirical Mode Decomposition
Creators: name: Breva, Yannick
name: Kröger, Johannes
name: Kersten, Tobias
name: Schön, Steffen
Publisher: name: Berlin ; Heidelberg : Springer
Year: 2022
Subjects: subject: Absolute antenna calibration
subject: Codephase center corrections
subject: Empirical mode decomposition
subject: Group delay variations
subject: Konferenzschrift
subject: Dewey Decimal Classification::500 | Naturwissenschaften::550 | Geowissenschaften

description: In high precision Global Navigation Satellite Systems (GNSS) applications, it is necessary to take phase center corrections (PCC) into account. Beside these corrections for carrier phase measurements, also corrections for the codephase are necessary, so called codephase center corrections (CPC). The CPC, also known as group delay variations, are antenna dependent delays of the received codephase, which are varying with azimuth and elevation of the incoming GNSS signal. A concept for estimating absolute CPC and PCC for multi GNSS signals has been established by the Institut für Erdmessung. In this paper, the standard calibration approach with a sampling rate of 1 Hz is briefly described, which works well for PCC estimation. The main challenge of this approach for estimating repeatable CPC patterns is the significantly higher noise to pattern ratio in the observations compared to PCC determination. Therefore, an alternative processing strategy is presented in this contribution. By increasing the sampling rate to 10 Hz, the empirical mode decomposition can be used to reduce the noise of the input observations by maintaining all pattern information. With this method, the calibration repeatability is improved by 46% to 60% for GPS and Galileo C1C signals for a geodetic antenna. Moreover, the estimated pattern is validated in the positioning domain with a single point positioning approach. By considering the estimated CPC the accuracy of the height component can be improved.
Breeding biology of mola carplet, (Amblypharyngodon mola, Hamilton, 1822) in semi-natural condition
Creators: name: Al-Asif, Abdulla
Publisher: name: figshare
Year: 2022
Subjects: subject: 70201 Animal Breeding
subject: FOS: Animal and dairy science
subject: 70401 Aquaculture
subject: FOS: Agriculture, forestry and fisheries
subject: 70402 Aquatic Ecosystem Studies and Stock Assessment

description: Background and Objective: The mola carplet, Amblypharyngodon mola is a representative small indigenous fish species that is enriched with different vitamins and minerals. The main objective of this study was to determine the reproductive biology of A. mola for better scientific management and conservation in hapa based culture, set up in a large earthen pond. Materials and Methods: The experiment was conducted of three treatment with two replicates along hapa size varied treatment: T1 (2 m3), treatment: T2 (10 m3) and treatment: T3 (20 m3) with two replicates each and the stocking density in those hapas were 50, 250 and 500g, respectively in April, 2012 to March, 2013. Some biological characteristics, gonad weight, Gonadosomatic Index (GSI) and condition factor (K) of both sexes were observed. Results: Cycle of gonadal maturation and month-wise variations were documented with their fecundity, size-frequency of intra-ovarian oocytes in females. Throughout the suitable physic-chemical parameters, monthly microscopic examination of gonad revealed five maturity stages of female A. mola but male showed same four stages. Ripe ova have been observed for nine consecutive months (April to December) which referring extended the breeding season. Considering the stocking density and hapa sizes, A. mola bred the highest frequency in T3 during the culture period. Different size classes of intraovarian oocytes have portrayed the batch-wise (asynchronous) development of oocytes in A. mola throughout the culture period. Conclusion: This evidence suggests that A. mola has its inherent regulating mechanism of oocyte development adapted to the annual life of the fish, in spite of their single spawning habit, they discharge all oocytes in different batches throughout the spawning season.
On the Effect of Antenna Calibration Errors on Geodetic Estimates: Investigation on Zero and Double Difference Approaches
Creators: name: Kersten, Tobias
name: Krzan, Grzegorz
name: Dawidowicz, Karol
name: Schön, Steffen
Publisher: name: Berlin ; Heidelberg : Springer
Year: 2022
Subjects: subject: Coordinates
subject: Double difference (DD)
subject: Generic patterns
subject: Phase centre corrections (PCC)
subject: Zenith tropospheric delays (ZTD)
subject: Zero difference (ZD)
subject: Konferenzschrift
subject: Dewey Decimal Classification::500 | Naturwissenschaften::550 | Geowissenschaften

description: This paper addresses an approach to assess the impact of phase centre correction errors of selected receiving antennas in the Polish ASG-Eupos network using GNSS processing strategies such as zero differencing and double differencing. The objective is to characterise the nature of the error patterns of GNSS receiver antennas and to understand their impact on GNSS derived integrated water vapour and geodetic estimates. A semi-analytical approach for characterising variants of error patterns is applied. Differences of up to +12 mm between type-mean and individual receiver antenna calibrations of current antenna models on the ionosphere-free linear combination are identified for repeatable pattern deformations. The analyses show that repeatable effects on tropospheric estimates of up to 8 mm – which corresponds to approx. 1.2 kg/m2 – occur even though only 5 mm variations were applied to the pattern. The results of our analysis show a strong correlation with the type of error patterns that affect the estimates differently. Due to the complex relationship between datum settings, processing strategy, baseline orientation and satellite sky distribution, artefacts in GNSS processing models and their effects must to be modelled in order to achieve a better understanding in the context of GNSS networks and GNSS meteorology.
Particle motion and diffusion at weak bed load: accounting for unsteadiness effects of entrainment and disentrainment
Creators: name: Campagnol, Jenny
name: Radice, Alessio
name: Ballio, Francesco
name: Nikora, Vladimir
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 60506 Virology
subject: FOS: Biological sciences
subject: Cancer
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Cell Biology
subject: Microbiology
subject: Engineering
subject: Biochemistry

description: ABSTRACTA study of weak bed load over a plane bed is presented with a particular focus on the motion and diffusion of individual particles that were tracked along their movements. Grain position, velocity and acceleration were measured with particle-scale resolution; ensemble statistics over a significant sample of particle trajectories were then computed, enabling unsteady phases of particle motion (corresponding to entrainment and disentrainment) to be identified. Based on the experimental findings, a physically-based conceptual model for particle kinematics consisting of an initial (entrainment) unsteady phase, a quasi-steady phase, and a final (disentrainment) unsteady phase is explored. The unsteadiness effects in particle dispersion due to entrainment and disentrainment, typically overlooked in previous studies, are explicitly quantified by analysing the time evolution of the particle position variance. Starting with a previously published model of particle diffusion, a refined model is proposed which explicitly accounts for the unsteadiness effects in particle motion.
Refined models of New Delhi metallo-beta-lactamase-1 with inhibitors: an QM/MM modeling study
Creators: name: Yeng-Tseng Wang
name: Tian-Lu Cheng
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: New Delhi metallo-beta-lactamase 1 (NDM-1) has been identified as a potential target for the treatment of multi-drug resistance bacterial infections. We used molecular docking, normal MD, SIE, QM/MM MD simulations, QM/MM GBSA binding free energy, and QM/MM GBSA alanine-scanning mutagenesis techniques to investigate interactions of the NDM-1 with 11 inhibitors (Tigecycline, BAL30072, D-captopril, Penicillin G, Ampicillin, Carbenicillin, Cephalexin, Cefaclor, Nitrocefin, Meropenem, and Imipenem). From our normal MD and QM/MM simulations, the correlation coefficients between the predicted binding free energies and experimental values are .88 and .93, respectively. Then simulations, which combined QM/MM/GBSA and alanine-scanning mutagenesis techniques, were performed and our results show that two residues (Lys211 and His250) have the strongest impact on the binding affinities of the 11 NDM-1/inhibitors. Therefore, our approach theoretically suggests that the two residues (Lys211 and His250) are responsible for the selectivity of NDM-1 associated inhibitors. Difference in the predicted binding free energy of the virtual alanine mutations of the NDM-1 with the 11 inhibitors.
Kalman-Filter Based Hybridization of Classic and Cold Atom Interferometry Accelerometers for Future Satellite Gravity Missions
Creators: name: HosseiniArani, Alireza
name: Tennstedt, Benjamin
name: Schilling, Manuel
name: Knabe, Annike
name: Wu, Hu
name: Schön, Steffen
name: Müller, Jürgen
Publisher: name: Berlin ; Heidelberg : Springer
Year: 2022
Subjects: subject: Atom interferometry
subject: Hybrid accelerometer
subject: Quantum sensor
subject: Satellite gravimetry
subject: Konferenzschrift
subject: Dewey Decimal Classification::500 | Naturwissenschaften::550 | Geowissenschaften

description: Proof-of-principle demonstrations have been made for cold atom interferometer (CAI) sensors. Using CAI-based accelerometers in the next generation of satellite gravimetry missions can provide long-term stability and precise measurements of the non-gravitational forces acting on the satellites. This would allow a better understanding of climate change processes and geophysical phenomena which require long-term monitoring of mass variations with sufficient spatial and temporal resolution. The proposed accuracy and long-term stability of CAI-based accelerometers appear promising, while there are some major drawbacks in the long dead times and the comparatively small dynamic range of the sensors. One interesting way to handle these limitations is to use a hybridization with a conventional navigation sensor. This study discusses one possible solution to employ measurements of a CAI accelerometer together with a conventional Inertial Measurement Unit (IMU) using a Kalman filter framework. A hybrid navigation solution of these two sensors for applications on ground has already been demonstrated in simulations. Here, we adapt this method to a space-based GRACE-like gravimetry mission. A simulation is performed, where the sensitivity of the CAI accelerometer is estimated based on state-of-the-art ground sensors and further published space scenarios. Our results show that the Kalman filter framework can be used to combine the measurements of conventional inertial measurement units with the CAI accelerometers measurements in a way to benefit from the high accuracy of the conventional IMU measurements in higher frequencies together with the high stability of CAI measurements in lower frequencies. We will discuss the challenges, potential solutions, and the possible performance limits of the proposed hybrid accelerometry scenario.