cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The characterisation, pharmacology and applications of stem cell derived Endothelial cells
Creators: name: Reed, Daniel Mark
Publisher: name: Imperial College London
Year: 2014

description: Stem cell derived endothelial cells have a growing number of applications in clinical medicine and biomedical research and will be critical in any organ regeneration programme. Endothelial cells can now be derived from a number of distinct stem cell populations including embryonic stem cells, blood progenitors and induced pluripotent stem cells. In order for stem cell derived endothelial cells to be used optimally it is important that they are fully assessed for the cardinal characteristics of endothelial cells on mature vessels. With this in mind, in my thesis I have assessed the ability of stem cell derived endothelial cells to display hallmarks of authentic endothelial cells from vessels including, alignment under shear stress, responses to pathogen stimuli and vasoactive hormone release. My group has previously shown that endothelial cells from human embryonic stem cells did not respond to agonists of toll-like receptor-4 (TLR4). TLR4 is important to allow endothelial cells to sense infection, but is also associated with cardiovascular disease. In my PhD, I showed that, whilst these cells have no TLR4 they have a fully functional NOD1 receptor pathway which allows the cells to sense Gram-negative bacteria. This may be relevant to their use therapeutically and allowed me to speculate that these cells are immune competent, but through lack of TLR4 might be protected from vascular inflammation. In order for stem cell derived endothelial cells to be useful in in vitro assays however, it is important that they express all the key hallmarks of endothelial cells from vessels. Endothelial cells grown from blood progenitors or from induced pluripotent stem cells did have TLR4 responses and released vasoactive hormones at levels comparable to endothelial cells from vessels. In the later part of my PhD, I applied endothelial cells derived from blood progenitor cells to key assays to study endothelial cell biology and pharmacology. This included an assay to detect cytokine storm reactions to drugs, which currently limits the development of biological drugs. This assay, employing cells derived from stem cells of individual patients also has applications in personalised medicine. In my final chapter, I was able to grow BOEC from a patient with a homozygous mutation that results in loss of function of the enzyme cPLA2, which is thought to be critical to prostaglandin and prostacyclin release, and used these cells to study this pathway. I showed that cPLA2α is the dominant isoform responsible for the release of prostacyclin from endothelial cells and provided a proof-of-concept that BOEC can be used to phenotype patients. In summary, my thesis includes characterisation of stem cell derived endothelial cells, and includes applications of adult progenitor derived cells in assays to study pharmacology and cell biology with a view to developing personalised medicines and cell therapies.
Negative thermal magnetoresistivity as a signature of chiral anomaly in Weyl superconductors
Creators: name: Kobayashi, Takuro
name: Matsushita, Taiki
name: Mizushima, Takeshi
name: Tsuruta, Atsushi
name: Fujimoto, Satoshi
Publisher: name: arXiv
Year: 2018
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We propose that chiral anomaly of Weyl superconductors gives rise to negative thermal magnetoresistivity induced by emergent magnetic fields, which are generated by vortex textures of order parameters or lattice strain. We establish this scenario by combining the argument based on Berry curvatures, and the quasi-classical theory of the Eilenberger equation with quantum corrections arising from inhomogeneous structures. It is found that the chiral anomaly contribution of the thermal conductivity exhibits characteristic temperature dependence, which can be a smoking-gun signature of this effect.
description: 10 pages, 3 figures, the version accepted for publication in Physical Review Letters
Investigating inhibitors of the IgE:high affinity receptor protein-protein interaction
Creators: name: Smith, Lucy
Publisher: name: Imperial College London
Year: 2014

description: The protein-protein interaction (PPI) between immunoglobulin E (IgE) and its high affinity receptor (FcεRI) is an important part of the allergic response. Inhibition of the IgE:FcεRI interaction is a key strategy for the development of allergy treatments. This PPI has been validated as a therapeutic target by the humanised monoclonal antibody omalizumab, which binds to IgE and prevents the formation of the IgE:FcεRI complex and has proved successful at treating allergic asthma. However, small molecule inhibitors of the IgE:FcεRI PPI that are orally available would be a more desirable form of treatment. This thesis describes the design, synthesis and testing of two series of inhibitors of the IgE:FcεRI interaction; small molecules based on the natural product aspercyclide A and short, linear peptides based on a key binding epitope of FcεRI. It also describes the development of a high-throughput time resolved fluorescence resonance energy transfer (TR-FRET) assay to test inhibitors and subsequent x-ray crystallography and SPR experiments to further investigate the mode of action of the inhibitors. An analogue of aspercyclide A has shown inhibition of the IgE:FcεRI interaction in the micromolar range and an improved potency compared to the natural product itself. A number of 8-residue, linear peptides have been found to inhibit the IgE:FcεRI PPI in the micromolar range when tested in the TR-FRET assay. The most potent peptide has been biotinylated and immobilised for SPR experiments with IgE and FcεRI. These SPR experiments suggest that the peptide inhibits the IgE:FcεRI interaction by binding to the high affinity receptor rather than to IgE.
Charge redistribution in correlated heterostuctures within nonequilibrium real-space dynamical mean-field theory
Creators: name: Titvinidze, Irakli
name: Sorantin, Max E.
name: Dorda, Antonius
name: von der Linden, Wolfgang
name: Arrigoni, Enrico
Publisher: name: arXiv
Year: 2018
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We address the steady-state behavior of a system consisting of several correlated monoatomic layers sandwiched between two metallic leads under the influence of a bias voltage. In particular, we investigate the effect of the local Hubbard and of the long-range Coulomb interactions on the charge redistribution at the interface. We provide a detailed study of the importance of the various system parameters, like Hubbard $U$, lead-correlated region coupling strength, and the applied voltage on the charge distribution in the correlated region and in the adjacent parts of the leads. Our results are obtained within non-equilibrium (steady-state) real-space dynamical mean-field theory (R-DMFT), with a self-consistent treatment of the long-range part of the Coulomb interaction by means of the Poisson equation. The latter is solved by the Newton-Raphson method and we find that this significantly reduces the computational cost compared to existing treatment. As impurity solver for R-DMFT we use the auxiliary master equation approach (AMEA), which addresses the impurity problem within a finite auxiliary system coupled to Markovian environments.
description: 14 pages, 8 figures
Lithium depletion in the sun: a study of mixing based on hydrodynamical simulations
Creators: name: Bloecker, T.
name: Holweger, H.
name: Freytag, B.
name: Herwig, F.
name: Ludwig, H. -G.
name: Steffen, M.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Based on radiation hydrodynamics modeling of stellar convection zones, a diffusion scheme has been devised describing the downward penetration of convective motions beyond the Schwarzschild boundary (overshoot) into the radiative interior. This scheme of exponential diffusive overshoot has already been successfully applied to AGB stars. Here we present an application to the Sun in order to determine the time scale and depth extent of this additional mixing, i.e. diffusive overshoot at the base of the convective envelope. We calculated the associated destruction of lithium during the evolution towards and on the main-sequence. We found that the slow-mixing processes induced by the diffusive overshoot may lead to a substantial depletion of lithium during the Sun's main-sequence evolution.
description: 8 pages including 4 PostScript figures, using spackap.sty, Proc. of the workshop "Solar Composition and its Evolution - From Core to Corona, to appear in Space Science Reviews, also available from http://www.speckle.mpifr-bonn.mpg.de/publications.html
Design and implementation of a mammalian synthetic gene oscillator
Creators: name: Sant'Ana Pereira, Hugo
Publisher: name: Imperial College London
Year: 2016

description: The core goal of synthetic biology as a discipline is to design, develop and characterize biological parts in order to precisely control cellular behaviour. Much of the research in this field has been focused on the development of gene regulatory networks, namely switches and oscillators. The study of synthetic gene oscillators has attracted significant attention in the past decade due to their intriguing dynamics and relevance in controlling inflammatory, metabolic and circadian signalling pathways. Additionally, the precise expression dynamics and molecular mechanisms that underlie the mammalian circadian clock structure are not fully understood. The work presented herein regards the design and implementation of a tuneable mammalian synthetic gene oscillator with a novel biological structure. To this end, an approach based on a combination of in silico design and in vivo part validation, in conjunction with a comparative analysis of previously implemented synthetic gene oscillators, was taken when assembling the proposed system. The topology of the system relies on a delayed negative feedback loop, consisting of the coupled regulatory activities of the transcription regulators LacI, tTA, and Gal4. The numerical solution and stability analysis of an ODE-based model describing the dynamics of the system are indicative that the proposed system is capable of generating sustained oscillations across a wide range of parameter values. The biological parts that comprise the system have been monitored and validated in HEK293T cells through time-lapse fluorescence microscopy and image analysis. The in vivo performance of the proposed mammalian synthetic gene oscillator was also assessed in the HEK293T cell line, and monitored using time-lapse fluorescence microscopy. Damped fluorescence oscillations were observed: these could be tuned by a differential IPTG concentration gradient and abolished by doxycycline. The proposed mammalian synthetic gene oscillator provides valuable insight into the gene expression regulatory processes leading to oscillatory behaviour, and has the potential to foster progress in future synthetic biology-based therapies.
A Review of Recent Developments in Atomic Processes for Divertors and Edge Plasmas
Creators: name: Post, D. E.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: The most promising concepts for power and particle control in tokamaks and other fusion experiments rely upon atomic processes to transfer the power and momentum from the edge plasma to the plasma chamber walls. This places a new emphasis on processes at low temperatures (1-200 eV) and high densities (10^20-10^22 m^-3). The most important atomic processes are impurity and hydrogen radiation, ionization, excitation, recombination, charge exchange, radiation transport, molecular collisions, and elastic scattering of atoms, molecules and ions. Important new developments have occurred in each of these areas. The best available data for these processes and an assessment of their role in plasma wall interactions are summarized, and the major areas where improved data are needed are reviewed.
description: Preprint for the 11th PSI meeting, postscript with 22 figures, 40 pages
Additional file 1: of The landscape of vaccines in China: history, classification, supply, and price
Creators: name: Zheng, Yaming
name: Rodewald, Lance
name: Yang, Juan
name: Qin, Ying
name: Pang, Mingfan
name: Feng, Luzhao
name: Yu, Hongjie
Publisher: name: figshare
Year: 2018
Subjects: subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Table S1. Vaccine supplied in China, 2007â 2016; The table contains the vaccine preventable diseases, name of vaccine, acronyms, category, year of license, year of EPI, number of domestic and international manufacturers. Table S2. The vaccines not supplied in China but in UK and US; The table contains the vacciens supplied in UK and USA but not supplied in China. Figure S1. The national immunization program vaccines in China, UK, US, Russia, Brazil, India and South Africa. The figure contains vaccines integrated in EPI in China, UK, US, Russia, Brazil, India and South Africa in Green and vaccines not included in EPI in China in Gold. (DOCX 40 kb)
title: Functionalisation of polyoxometalates: towards advanced applications in catalysis and materials
Creators: name: Lydon, Claire Elizabeth
Publisher: name: University of Glasgow
Year: 2011
Subjects: subject: Polyoxometalate.

description: This thesis focuses on reactions involving the assembly of polyoxometalate building blocks, specifically the Wells-Dawson trilacunary species [P2W15O56]12-. This reactive fragment can have the vacant sites filled with a variety of transition metals and can form extended architectures.
The variables of a reaction intended to substitute various transition metals into the lacunary Dawson species were systematically tested. This resulted in the formation of numerous structures, some of which were recurring with different transition metals and some of which were found to have interesting magnetic properties. The magnetic properties of a Ni-W cubane were studied and it was shown to display ferromagnetic coupling behaviour. A nine Co atom containing trimer and fourteen Co atom containing tetrameric compound were synthesised and their magnetic properties studied. The tetrameric compound was found to display single molecule magnet behaviour. A Mn trimer analogous to the Co atom trimer was also synthesised as were two ‘banana-shaped’ sandwich clusters with either Mn or Co.
The V substituted {P2W15} fragment has been widely used for hybrid applications and it was discovered that this compound can form a sandwich cluster with a V oxide double cubane in the centre of the two POMs. This cluster was studied by mass spectrometry, x-ray diffractometry and electrochemical methods and was found to have interesting electronic properties.
New analogues of previously known {P2W15V3} dumbbell structures were synthesised with a view to studying vesicle formation. The compounds presented here have functional groups that have not been incorporated into these structures before.
Sirepo: Domain-Rich Computational Physics Gateway
Creators: name: Nagler, Robert
name: Moeller, Paul
name: Bruhwiler, David
name: Rakitin, Maksim
name: Chubar, Oleg
Publisher: name: figshare
Year: 2018
Subjects: subject: Computer Software
subject: FOS: Computer and information sciences
subject: Computational Physics

description: Sirepo is an open source, domain-rich gateway for computational science. Sirepo is used by both novice and expert physicists and engineers to simulate electromagnetic radiation and charged particle dynamics. Key design objectives are seamless integration with legacy codes, low barrier to entry for new users, configuration transfer to command line mode, catalogue of provenance to aid reproducibility, and simplified collaboration through multimodal sharing.
SELI
Creators: name: MAUFFRET Aourell
Publisher: name: Sismer
Year: 2016

description: Le dispositif « SELI » est mis en place depuis 2016 pour acquérir des données sur les effets biologiques intégrateurs de la contamination chimique chez des organismes marins (poissons et bivalves) et ainsi renseigner le critère 2 du descripteur 8 de la DCSMM (Le niveau de concentration des contaminants ne provoque pas d'effets dus à la pollution). Il permet aussi de renseigner les bases de données des conventions des mers régionales OSPAR et MEDPOL sur le suivi de la contamination chimique et de ses effets. Les biomarqueurs suivis ciblent 1) des effets sur plusieurs grandes fonctions biologiques : reprotoxicité, génotoxicité, neurotoxicité ainsi que 2) la santé générale de l'organisme. Les contaminants suivis dans les organismes sont les éléments traces métalliques et les contaminants organiques hydrophobes (historiques et émergents) susceptibles de s'accumuler dans les organismes et de s'amplifier dans les réseaux trophiques. SELI se décline en 3 sous-dispositifs, un sous-dispositif étant mis en oeuvre par année, et donc chaque sous-dispositif étant mis en oeuvre tous les 3 ans : SELIMED : suivi des effets de la contamination chez les rougets barbets (Mullus barbatus) et les moules (Mytilus galloprovincialis) dans le golfe du Lion (début : 2016). SELILOIRE : suivi des effets de la contamination chez les soles (Solea solea) et les moules (Mytilus edulis) dans l'estuaire de Loire et Vilaine (début : 2017). SELISEINE : suivi des effets de la contamination chez les soles (Solea solea), les flets (Platichthys flesus) et les moules (Mytilus edulis) dans la Baie de Seine (début : 2018).L'ensemble de ces analyses permet de répondre aux questions :- Quel est le niveau d'imprégnation des organismes à la contamination chimique ?- Quelles sont les réponses biologiques observées ? Peuvent-elles être associées à l'exposition à un stress chimique dans des zones de pressions anthropiques variées ?
Rauvolfia tetraphylla Linnaeus 1753
Creators: name: Jarvis, Charlie
Publisher: name: Linnaean Society of London in association with the Natural History Museum
Year: 2007
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Gentianales
Apocynaceae
Rauvolfia
Rauvolfia tetraphylla

description: Rauvolfia canescens Linnaeus, Species Plantarum, ed. 2, 1: 303. 1762.
"Habitat in Jamaica." RCN: 1701.
Type not designated.
Original material: Browne, Herb. Linn. No. 293.4 (LINN).
Current name: Rauvolfia tetraphylla L. (Apocynaceae).
Note: Rendle (in Proc. Linn. Soc. London 149: 108. 1937) says the name is "founded on" Browne specimens in LINN, which he illustrates as his pl. 3 (= 293.4 LINN). However, "founded on" is not accepted as an equivalent of “type”.
description: Published as part of Jarvis, Charlie, 2007, Chapter 7: Linnaean Plant Names and their Types (part R), pp. 785-805 in Order out of Chaos. Linnaean Plant Types and their Types, London :Linnaean Society of London in association with the Natural History Museum on page 788, DOI: 10.5281/zenodo.291971
The approach to equilibrium in N-body gravitational systems
Creators: name: El-Zant, Amr
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The evolution of closed gravitational systems is studied by means of $N$-body simulations. This, as well as being interesting in its own right, provides insight into the dynamical and statistical mechanical properties of gravitational systems: the possibility of the existence of stable equilibrium states and the associated relaxation time would provide an ideal situation where relaxation theory can be tested. Indeed, these states are found to exist for single mass $N$-body systems, and the condition condition for this is simply that obtained from elementary thermodynamical considerations applied to self-gravitating ideal gas spheres. However, even when this condition is satisfied, some initial states may not end as isothermal spheres. It is therefore only a necessary condition. Simple considerations also predict that, for fixed total mass, energy and radius, stable isothermal spheres are unique. Therefore, statistically irreversible perturbations to the density profile caused by the accumulation of massive particles near the centre of multimass systems, destroy these equilibria if the aforementioned quantities are kept fixed. The time-scale for this to happen was found to be remarkably short (a few dynamical times when $N= 2500$) in systems undergoing violent relaxation. The time taken to achieve thermal equilibrium depended on the initial conditions and could be comparable to a dynamical time (even when the conditions for violent relaxation were not satisfied) or the two body relaxation time. The relaxation time for velocity anisotropies was intermediate between these two time-scales, being long compared to the dynamical time but much (about four times) shorter than the time-scale of energy relaxation.
description: To appear in Physical Review E
The IRIE - Universitat de les Illes Balears CoARA Action Plan 2024-2027
Creators: name: Carranza-Guasch, Miguel
Publisher: name: Zenodo
Year: 2024

description: This document describes the action plan that the IRIE undertakes to carry out between 2024 and 2027, which was approved by the Executive Board on May 22, following a process of internal consultation and participation.

The Institute for Educational Research and Innovation (IRIE) is since April 19th 2024 member of the Coalition for Advancing Research Assessment (CoARA). Part of the commitment to CoARA is the development of a four-year institutional action plan to fulfill the Agreement on Reforming Research Assessment.
Coarsening and percolation in the kinetic $2d$ Ising model with spin exchange updates and the voter model
Creators: name: Tartaglia, Alessandro
name: Cugliandolo, Leticia F.
name: Picco, Marco
Publisher: name: arXiv
Year: 2018
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences
subject: 82C20

description: We study the early time dynamics of bimodal spin systems on $2d$ lattices evolving with different microscopic stochastic updates. We treat the ferromagnetic Ising model with locally conserved order parameter (Kawasaki dynamics), the same model with globally conserved order parameter (nonlocal spin exchanges), and the voter model. As already observed for non-conserved order parameter dynamics (Glauber dynamics), in all the cases in which the stochastic dynamics satisfy detailed balance, the critical percolation state persists over a long period of time before usual coarsening of domains takes over and eventually takes the system to equilibrium. By studying the geometrical and statistical properties of time-evolving spin clusters we are able to identify a characteristic length $\ell_p(t)$, different from the usual length $\ell_d(t) \sim t^{1/z_{d}}$ that describes the late time coarsening, that is involved in all scaling relations in the approach to the critical percolation regime. We find that this characteristic length depends on the particular microscopic dynamics and the lattice geometry. In the case of the voter model, we observe that the system briefly passes through a critical percolation state, to later approach a dynamical regime in which the scaling behaviour of the geometrical properties of the ordered domains can be ascribed to a different criticality.
description: 78 pages, 42 figures
Reminiscences of Leverett Saltonstall, 1967
Publisher: name: Columbia University
Year: 2020
Subjects: Legislators--United States
Government executives--United States
Korean War, 1950-1953

description: 1952 pre-convention period and campaign; transition period; Senate Armed Services Committee; Appropriations Committee; White House legislative conferences; Republican politics, 1952-60; President Eisenhower's relations with Congress, his appointments; use of non-obligated funds; unification of the armed services; Korean War; Tuesday morning meetings; financial policy of Dept. of Defense
Calculations of Energy Losses due to Atomic Processes in Tokamaks with Applications to the ITER Divertor
Creators: name: Post, D.
name: Abdallah, J.
name: Clark, R. E. H.
name: Putvinskaya, N.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: Reduction of the peak heat loads on the plasma facing components is essential for the success of the next generation of high fusion power tokamaks such as the International Thermonuclear Experimental Reactor (ITER) 1 . Many present concepts for accomplishing this involve the use of atomic processes to transfer the heat from the plasma to the main chamber and divertor chamber walls and much of the experimental and theoretical physics research in the fusion program is directed toward this issue. The results of these experiments and calculations are the result of a complex interplay of many processes. In order to identify the key features of these experiments and calculations and the relative role of the primary atomic processes, simple quasi-analytic models and the latest atomic physics rate coefficients and cross sections have been used to assess the relative roles of central radiation losses through bremsstrahlung, impurity radiation losses from the plasma edge, charge exchange and hydrogen radiation losses from the scrape-off layer and divertor plasma and impurity radiation losses from the divertor plasma. This anaysis indicates that bremsstrahlung from the plasma center and impurity radiation from the plasma edge and divertor plasma can each play a significant role in reducing the power to the divertor plates, and identifies many of the factors which determine the relative role of each process. For instance, for radiation losses in the divertor to be large enough to radiate the power in the divertor for high power experiments, a neutral fraction of 10-3 to 10-2 and an impurity recycling rate of netrecycle of ~ 10^16 s m^-3 will be required in the divertor.
description: Preprint for the 1994 APSDPP meeting, uuencoded and gzipped postscript with 22 figures, 40 pages.
title: ADCO, Cartulaire de Cîteaux pour la grange et seigneurie d'Ouges (XVe siècle), Cart. 173 (11 H 939), 226 folios, f. 0224
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2015
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire de Cîteaux pour la grange et seigneurie d'Ouges (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 173 (11 H 939), 226 folios, f. 0224, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour la grange et seigneurie d'Ouges (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 173 (11 H 939), 226 folios, f. 0224, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: abbaye de Cîteaux
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: http://www.wikidata.org/entity/Q843261
Rauvolfia tetraphylla Linnaeus 1753
Creators: name: Jarvis, Charlie
Publisher: name: Linnaean Society of London in association with the Natural History Museum
Year: 2007
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Gentianales
Apocynaceae
Rauvolfia
Rauvolfia tetraphylla

description: Rauvolfia subpubescens Linnaeus, Mantissa Plantarum Altera: 345. 1771, nom. illeg.
RCN: 1701.
Replaced synonym: Rauvolfia hirsuta Jacq. (1760).
Type not designated.
Current name: Rauvolfia tetraphylla L. (Apocynaceae).
Note: An illegitimate replacement name for R. hirsuta Jacq. (1760).
description: Published as part of Jarvis, Charlie, 2007, Chapter 7: Linnaean Plant Names and their Types (part R), pp. 785-805 in Order out of Chaos. Linnaean Plant Types and their Types, London :Linnaean Society of London in association with the Natural History Museum on page 788, DOI: 10.5281/zenodo.291971
DCE-BENTHOS
Creators: name: FOVEAU Aurélie
Publisher: name: Sismer
Year: 2018

description: Dans le cadre de la DCE, cette série vise à échantillonner les stations subtidales des façades Seine-Normandie et Artois-Picardie pour répondre à la surveillance des masses d'eaux côtières ou de transition pour le paramètre macro-invertébrés benthiques.
Assessing the safety profile of antisense therapeutics through a novel computational and analytical framework
Creators: name: Kamola, Piotr
Publisher: name: Imperial College London
Year: 2015

description: With many safety and technical limitations partly mitigated through chemical modifications, antisense oligonucleotides (ASOs) are gaining recognition as therapeutic entities. The increased potency realised by ‘third generation chemistries’ may, however, simultaneously increase affinity to unintended targets with partial sequence complementarity. Hybridisation-dependent off-target effects (OTEs), a risk historically regarded as low, are not being adequately investigated. My data shows an unexpectedly high OTEs confirmation rate for locked nucleic acid gapmer ASOs, showing a wide range of mismatch (MM) and gap patterns. Critically, hybridisation predicted against intronic regions of pre-mRNAs was tested and confirmed. This dramatically increases the ASO-binding landscape which, together with the high potency of such interactions, is a serious safety concern. OTEs were also found to translate in vivo in the mouse and highly correlate with observed hepatotoxcity. With base pairing-driven target recognition it is possible to predict the putative off-targets and a novel software pipeline (‘RNArcher’) was developed to address several challenges faced during ASO drug discovery. While the presence of chemical modifications limited the thermodynamics analysis of ASOs, the concept was applied to siRNAs. A correlation was found between the sequence composition of siRNA non-seed region (and its target sites) and seed-dependent OTEs that can be used to increase specificity of this modality. Overall, the hybridisation-mediated exonic and intronic OTEs are a significant safety concern for ASOs with 3rd generation chemistry. The ASO and siRNA-based guidelines and computational solutions developed throughout this project will aid the community in designing more specific molecular biology tools and safer therapeutics.
Visualizing the macroscale spatial distributions of biofilms in complex flow channels using industrial computed tomography
Creators: name: Xiao, Yang
name: Sawicka, Barbara
name: Liu, Yaoze
name: Zhou, Bo
name: Hou, Peng
name: Li, Yunkai
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: The presence of biofilms in enclosed pipelines can lead to numerous deleterious issues. To date, it has been difficult to use optical imaging techniques to monitor the macroscale spatial distributions of biofilms. To address this concern, a combination of industrial computed tomography (ICT) and a contrast agent was explored to noninvasively visualize biofilms in three types of drip irrigation emitters. The results showed that ICT successfully observed and quantified the macroscale spatial distributions of biofilms. The complex hydrodynamic characteristics in the emitter channels affected the local distributions of biofilms. Biofilms were mainly attached to the lateral and medial faces and biomass decreased along the flow directions. Based on the distributions of biofilms, some emitter structural design defects were further diagnosed. Applying ICT in combination with the contrast agent could potentially provide a visual and effective way to reveal the formation mechanisms of biofilms and to optimize flow channel structures to avoid biofilm accumulations.
title: Synthesis of Cyclopentenone Isoprostanes and Highly Functionalized Cyclopentanes
Creators: name: Cirule, Dace
Publisher: name: Universität Bern
Year: 2024
Subjects: subject: 540 Chemistry

description: Cyclopentane ring itself or as an element of bicyclic or polycyclic systems is not only ubiquitous in nature but also an increasingly recognized structural motif for biomedical research and drug discovery. In this context, the first part of the thesis describes our efforts towards synthetic analogs of a natural epoxy cyclopentenone isoprostane known to possess anti-inflammatory bioactivity. Employing reported strategies seven novel cyclopentenone isoprostanes were provided to our collaborators to examine their bioactivity. Additionally, preliminary studies demonstrated that the analog bearing an azide functionality could be labeled with an alkyne-containing cyanine (Cy5) and thus could serve as a valuable tool to further study the signaling pathway of related isoprostanes.
While numerous methodologies have been developed for the synthesis of this structural entity, the employment of known strategies to access relevant structural analogs can still be tedious and challenging. Acknowledging that, the second part of the thesis covers our investigations towards the use of vinylboron derivatives in radical-mediated [3 + 2] annulation reactions. The development of an efficient route giving access to 1,1-diborylethene in gram scale allowed us to extend the scope of this reaction allowing the synthesis of substituted cyclopentanes flanked with two boronic ester moieties. The established processes are operationally simple, convergent, atom economical, and mild. Thus, the synthesis of cyclopentanes presenting sensitive functional groups is enabled.
Additionally, the utility of the synthesized cyclopentane platforms was demonstrated by taking advantage of the presence of either the iodine atom, the boron atom(s), or both functionalities. These functionalization products include intriguing and applicable bicyclo[3.1.0]hexanes decorated with a boronic ester moiety, allylic gem-diboronates, and homoallyiodides among others, and are all easily accessible in one or two steps.
The effect of increased colonic propionate production on appetite regulation and energy homeostasis in humans
Creators: name: Alhabeeb, Habeeb Ali S
Publisher: name: Imperial College London
Year: 2016

description: Propionate is a short chain fatty acid produced in the colon via fermentation of undigested foods. Elegant in vitro and in vivo studies have shown that increased production of propionate in the gut can reduce body weight and energy intake, and improve glucose homeostasis. These positive effects have been attributed to increased levels of the gut hormones, PYY and GLP-1, increased energy expenditure and improved beta-cell function. Furthermore, bariatric surgery increases levels of colonic propionate and this likely contributes to the huge weight loss seen with this treatment. Additionally, other short chain fatty acids and the consumption of fermentable carbohydrates to increase levels of short chain fatty acids can delay gastric emptying and affect the central regulation of appetite. Taken together, these findings suggest propionate could have several beneficial health effects in humans. Inulin-propionate ester was developed to deliver propionate to the colon. Effects of acute delivery of propionate to the colon with a single dose of inulin-propionate ester was investigated in healthy human volunteers on energy intake, subjective ratings of appetite and satiety and plasma glucose and insulin levels. Potential mechanisms for any effects were explored by assessing plasma levels of PYY and GLP-1, gastric emptying using 13C-octanoic acid, energy expenditure using indirect calorimetry, and central effects using fMRI. In addition, encapsulated sodium propionate was used to assess delivery to the small intestine on appetite and glucose and insulin levels. Acutely increasing colonic levels of propionate significantly reduced energy intake, increased satiety, increased levels of PYY and GLP-1, and reduced anticipatory food behaviour in humans. No effects were observed on gastric emptying, plasma levels of glucose and insulin and energy expenditure. In addition, delivery of propionate to the small intestine did not affect appetite or plasma levels of glucose and insulin. Colonic propionate significantly reduced energy intake and reduced appetite likely through increasing levels of GLP-1 and PYY and reducing anticipatory food behaviour. In addition, propionate does not affect appetite or glucose and insulin levels via the small intestine. As obesity is a growing epidemic, it is likely that interventions that increase colonic propionate levels could prevent weight gain or drive weight loss by regulating energy homeostasis.
Rauvolfia tetraphylla Linnaeus, 1753, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1753
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Gentianales
Apocynaceae
Rauvolfia
Rauvolfia tetraphylla

description: Rauvolfia tetraphylla, spec. nov.
 1. Rauvolfia. Hort. cliff. 75. t. 9.
 Rauvolfia tetraphylla angustifolia. Plum. gen.19.
 β. Rauvolfia tetraphylla latifolia. Plum. gen.19.
 Habitat in America calidiore. ♄
description: Published as part of Linnaeus, Carolus, 1753, Species plantarum: exhibentes plantas rite cognitas, ad genera relatas, cum differentiis specificis, nominibus trivialibus, synonymis selectis, locis natalibus, secundum systema sexuale digestas, Stockholm :Laurentius Salvius on page 208, DOI: 10.5281/zenodo.3931989
Reminiscences of Lewis J. Fields 1971
Publisher: name: Columbia University
Year: 2019
Subjects: Veterans
World War, 1939-1945--Naval operations, American
Vietnam War, 1961-1975

description: Education, St. John's College; Maryland National Guard, 1925-32; South Pacific, Australia, New Zealand, 1942-44; aide to United States Marine Corps Commandant, 1945-47; postwar demobilization; Supreme Headquarters Allied Powers Europe, 1954-56; Director of Personnel, Marine Corps Headquarters, 1962-65; Vietnam.
Archival searches for transient optical emission in the error box of the 1991 January 22 gamma-ray burst
Creators: name: Gorosabel, Javier
name: Castro-Tirado, Alberto
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present here the results of a study carried out at the Harvard College Observatory Plate Collection. We examined 3995 plates covering the error box of the gamma-ray burst GRB 910122, over a time span of 90 yr (from 1889 to 1979). The total exposure time is ~0.55 yr. No convincing evidence of optical transient emission was found within the GRB 910122 IPN error box. However, a possible OT was found outside the GRB 910122 error box. Optical ground based observations have revealed a V~22.3 object consistent with the position of the new object. The colours of the object are typical of a K7/M0 star or a reddened galaxy, which could have caused the OT, but the fact that the object is far away from the GRB error box makes both events unrelated.
description: 9 pages with 15 encapsulated PostScript figures included, gzipped tar format. Uses Astronomy & Astrophysics LaTeX macros. Accepted for publication in Astronomy & Astrophysics
ECHOSONDE
Creators: name: DORAY Mathieu
Publisher: name: Sismer
Year: 2017

description: La série de campagnes Echosonde a permis de réaliser des échosondages et de collecter des données hydrobiologiques sur l'écosystème pélagique autour de l'emplacement du futur parc éolien de Saint Nazaire et du site SEM-REV. Cette série s'intègre dans le projet Ifremer / Centrale Nantes / Pays de la Loire Ec(h)osonde qui a permis de déployer un observatoire de fond de mer acoustique intégré de l'impact des énergies marines renouvelables sur l'environnement pélagique dans le site SEM-REV. L'observatoire EchoSonde a également été testé avant déploiement pendant la série de campagnes.
Studies of Plasma Detachment Using a One Dimensional Model for Divertor Operation
Creators: name: Vesey, R. A.
name: Post, D. E.
name: Bateman, G.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: To characterize the conditions required to reach advanced divertor regimes, a one-dimensional computational model has been developed based on a coordinate transformation to incorporate two-dimensional effects. This model includes transport of ions, two species each of atoms and molecules, momentum, and ion and electron energy both within and across the flux surfaces. Impurity radiation is calculated using a coronal equilibrium model which includes the effects of charge-exchange recombination. Numerical results indicate that impurity radiation acts to facilitate plasma detachment and enhances the power lost from the divertor channel in escaping neutral atoms by cooling the electrons and suppressing ionization. As divertor particle densities increase, cold and thermal molecules become increasingly important in cooling the plasma, with molecular densities dominating electron and atomic densities under some conditions.
description: Preprint for the 11th International Conference on Plasma Surface Interactions in Mito, Japan (1994), uuencoded and gzipped postscript with 5 figures, 14 pages
Detailed Radiative Transport Modeling of a Radiative Divertor
Creators: name: Wan, A. S.
name: Dalhed, H. E.
name: Scott, H. A.
name: Post, D. E.
name: Rognlien, T. D.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: An effective radiative divertor maximizes the utilization of atomic processes to spread out the energy deposition to the divertor chamber walls and to reduce the peak heat flux. Because the mixture of neutral atoms and ions in the divertor can be optically thick to a portion of radiated power, it is necessary to accurately model the magnitude and distribution of line radiation in this complex region. To assess their importance we calculate the effects of radiation transport using CRETIN, a multi-dimensional, non-local thermodynamic equilibrium simulation code that includes the atomic kinetics and radiative transport processes necessary to model the complex environment of a radiative divertor. We also include neutral transport to model radiation from recycling neutral atoms. This paper presents a case study of a high-recycling radiative divertor with a typical large neutral pressure at the divertor plate to estimate the impact of H line radiation on the overall power balance in the divertor region with consideration for line opacities and atomic kinetics.
description: Preprint for the 11th International Conference on Plasma Surface Interactions in Mito, Japan (1994), uuencoded and gzipped postscript with 3 figures, 15 pages
Cytochalasins from endophytic Diaporthe sp. GDG-118
Creators: name: Huang, Xishan
name: Zhou, Dexiong
name: Liang, Yan
name: Liu, Xiaobo
name: Cao, Fei
name: Qin, Yuyue
name: Mo, Tuxiang
name: Xu, Zhaolong
name: Li, Jun
name: Yang, Ruiyun
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology
subject: Virology

description: The plant Sophora tonkinensis, possessed a range of active compounds, was traditionally used in the medicine of Chinese minorities. Endophytic fungi were isolated from this plant, of which the fungus Diaporthe sp. GDG-118 was fermented and extracted with methanol. The extract was screened by antifungal and antibacterial assays leading to the discovery of two new 21-acetoxycytochalasins (1–2) and five known cytochalasins (3–7). These two new compounds were elucidated by spectroscopic analyses, and further their absolute configurations were determined by the X-ray of compound 3 and comparing their experimental CD spectra. The antibacterial and antifungal effects of these compounds were evaluated. Compound 2 showed significant inhibitory activity against Bacillus anthraci and Escherichia coli with MIC value of 12.5 μg/mL, and 7 showed strong antifungal activity against Alternaria oleracea, Pestalotiopsis theae and Colletotrichum capsici with MIC values of 3.125, 1.56 and 1.56 μg/mL, respectively.
THEMISTO
Creators: name: COTTE Cédric
Publisher: name: Sismer
Year: 2016

description: L'objectif principal de THEMISTO est d'étudier la distribution en 3-D du zooplancton et du micronecton en lien avec les phénomènes physiques et climatiques. Le projet propose d'utiliser l'acoustique active comme outil de mesure de la distribution et des densités d'organismes. Grâce à l'acquisition en continu par l'échosondeur EK80 (à 5 fréquences, de plus de 1000m de profondeur pour le 18kHz jusqu'à 200m pour le 200kHz) lors des transits La Réunion-Crozet-Kerguelen-Amsterdam-La Réunion le but est de i) distinguer les groupes et espèces de zooplancton et micronecton et ii) caractériser la variabilité de leur distribution en 3-D sur un important gradient latitudinal (des régions tropicales à polaires). Les processus physiques sont étudiés simultanément (principalement données in-situ du thermosalinographe et analyses des images satellite), permettant de définir les habitats critiques multi-échelles d'espèces clés des écosystèmes du sud de l'océan Indien. Incluant une partie développement méthodologique pour tirer le meilleur profit du nouveau matériel embarqué et bénéficiant de collaborations (notamment REPCCOAI et OISO sur les campagnes Obsaustral au niveau national et MOBYDICK et MESOPP (Mesopelagic Southern Ocean Prey and Predators) en international), les résultats obtenus permettent de mieux comprendre les écosystèmes pélagiques mais aussi la contribution de ces informations en terme d'assimilation dans les modèles trophiques et de conservation via la planification spatiale
Rauvolfia tetraphylla Linnaeus 1753
Creators: name: Jarvis, Charlie
Publisher: name: Linnaean Society of London in association with the Natural History Museum
Year: 2007
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Gentianales
Apocynaceae
Rauvolfia
Rauvolfia tetraphylla

description: Rauvolfia tetraphylla Linnaeus, Species Plantarum 1: 208. 1753.
"Habitat in America calidiore." RCN: 1700.
Lectotype (Stearn, Introd. Linnaeus’ Sp. Pl. (Ray Soc. ed.): 47. 1957): [icon] " Rauvolfia " in Linnaeus, Hort. Cliff: 75, t. 9. 1738. - Voucher: Herb. Clifford: 75, Rauvolfia 1 (BM).
Generitype of Rauvolfia Linnaeus.
Current name: Rauvolfia tetraphylla L. (Apocynaceae).
Note: See extensive discussion by Rendle (in Proc. Linn. Soc. London 149: 108. 1937), Rao (in Ann. Missouri Bot. Gard. 43: 255, 285. 1956) and Fuchs (in Taxon 9: 37-40. 1960). Leeuwenberg (in Jarvis & al., Regnum Veg. 127: 81. 1993) designated a Clifford sheet as lectotype but this choice is pre-dated by that of Stearn.
description: Published as part of Jarvis, Charlie, 2007, Chapter 7: Linnaean Plant Names and their Types (part R), pp. 785-805 in Order out of Chaos. Linnaean Plant Types and their Types, London :Linnaean Society of London in association with the Natural History Museum on page 788, DOI: 10.5281/zenodo.291971