cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Role of Serine and Metallo-Hydrolase's in Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Like most solid tumors, it is metastasis from the primary tumor to secondary organs that is the leading cause of mortality in breast cancer. As such, the continued discovery of molecules underlying breast cancer development and metastasis and their molecular contribution to such processes remains an important and essential challenge for researchers. Extracellular and cell-surface enzymes from the serine and metallo-hydrolase family are known to play important roles during development and normal tissue homeostasis. In addition, these enzymes are believed to be important during primary tumor progression, invasion, and metastasis. For example, proteases are able to remodel the extracellular matrix and the basement membrane creating a pro-migratory and pro-invasive environment. This can occur through the degradation of the basement membrane to permit the passage of tumor cells to the blood and lymphatic vessels, or through the proteolysis and activation or inactivation of growth factors, growth factor receptors, cell-associated molecules and cytokines.

 To identify serine and metallo-hydrolase enzyme activities that could play a potential role in tumor progression and metastasis we propose the use of newly developed functional proteomic technologies. Our three major aims are to:

 • Identify serine and metallo-hydrolase enzyme activities that are elevated or decreased in an in vivo-derived breast cancer cell line that displays enhanced pathogenic properties compared to its parental cell line.

 • Test the contribution that identified enzyme activities provide to the aggressive properties of the in vivo-derived breast cancer line.

 • Profile serine and metallo-hydrolases activities across a panel of ductal and lobular primary human breast tumors.

 The identification of serine and metallo- hydrolase enzyme activities will involve a novel technology called activity-based protein profiling (ABPP), that utilizes active site-directed probes to measure changes in enzyme activity directly in native proteomes, in combination with an LC-MS based platform called multidimensional protein identification technology (MudPIT). ABPP-MudPIT will be used to profile enzyme activities in an in vivo derived breast cancer cell line that displays enhanced tumorigenic potential compared to its parental cell line. The contribution that identified protease activities provide to the aggressive properties of this breast cancer cell line will be tested by disrupting their expression using RNA interference. Finally, the potential contribution of these enzyme activities to the progression of primary human breast cancer will be examined by profiling a panel of ductal and lobular primary human breast tumors.
Eoferreola alwahaibii Schmid-Egger & Al-Jahdhami 2018
Creators: name: Gadallah, Neveen S.
name: Schmid-Egger, Christian
name: Brothers, Denis J.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Pompilidae
Eoferreola
Eoferreola alwahaibii

description: Eoferreola alwahaibii Schmid-Egger & Al-Jahdhami, 2018
Distribution in the Arabian Peninsula: Oman (Schmid-Egger & Al-Jahdhami 2018).
Extralimital distribution: No records.
description: Published as part of Gadallah, Neveen S., Schmid-Egger, Christian & Brothers, Denis J., 2020, Biodiversity of the aculeate wasps (Hymenoptera: Aculeata) of the Arabian Peninsula: Vespoidea, Pompilidae, pp. 153-173 in Zootaxa 4754 (1) on page 162, DOI: 10.11646/zootaxa.4754.1.16, http://zenodo.org/record/3719039
Biochemical study of a HIV-1 Gag - PR resistance mechanism
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The pandemic of human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) remains an unsolved scientific and medical problem. The research effort since the early 1980s led to a therapeutic strategy that renders an improved and prolonged lifespan, but it in the moment there is no cure, no vaccination and only limited therapy options for AIDS. Moreover, many patients fail therapy and have to change their regimen due to a phenomenon called drug resistance. This is a widely spread problem among HIV positive patients that demands an extensive monitoring of therapy and consequently adjustment of treatment. It is known that HIV is a highly versatile virus but how the virus escapes the cocktail of antiretroviral drugs remains to be clarified. Our goal is the investigation of drug resistance development and definition of a general paradigm that allows the prediction of therapy failure and improvement of therapy. In the past, we developed a novel technique that allows studies of an important viral process at a molecular level. Together with scientist at the University of California, San Diego (UCSD) and The Scripps Research Institute (TSRI) we intend to employ this technique to learn more about the underlying mechanism and make suggestions for future strategies. Moreover, we will pursue first steps towards new HIV therapeutics by employing the novel technique for dug discovery and inhibitor development. Many molecular processes during the HIV life cycle represent potential targets for current drug development. In collaboration with chemists at TSRI we will focus on a key function during virus production and provide new small compounds that potentially could be part of the antiviral drug pool.
Ursus arctos Linnaeus 1758
Creators: name: Jo, Yeong-Seok
name: Baccus, John T.
name: Koprowski, John L.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Carnivora
Ursidae
Ursus
Ursus arctos

description: Ursus arctos Linnaeus, 1758 —Brown Bear
Ursus arctos Linnaeus, 1758 p.47; Type locality- Sweden; Won, 1968 p.271; Han, 1994 p.46; Won & Smith, 1999 p.17; Oh, 2004a p.165.
U. lasiotus Gray, 1867 p.301; Type locality- interior of northern China.
Melanarctos cavifrons Heude, 1901 p.1; Type locality- northwestern Manchuria.
U. cavifrons: Kishida & Mori, 1931 p.379.
U. arctos lasiotus: Kuroda, 1938 p.31; Ellerman & Morrison-Scott, 1951 p.238; Won, 1958 p.440; Won, 1967 p.122; Won, 1968 p.273.
U. arctos arctos: Yoon, 1992 p.99.
Range: The distribution of U. arctos covers most northern alpine habitats and extends to the southern boundary at Mt. Geumgang (Kim et al. 2015; Fig. 40). Although this bear species was recorded around Mt. Baekdu until the 1980s, the current presence in the Mt. Geumgang and Mt. Baekdu areas in North Korea remains uncertain.
Remarks: The Subspecies U. a. lasiotus Gray, 1867, Ussuri brown bear (or Amur brown bear, black grizzly or horse bear) in northeastern Asia traditionally included the Korean Peninsula.
Conservation status: North Korea designated two brown bear habitats (Ryongrim, Jagang Province and Gwanmobong, Hamgyeongbuk Province) as Natural Monuments in 1980. The Red Data Book of North Korea lists this species as ‘Vulnerable’ (MAB National Committee of DPR Korea 2002). Populations in China and Mongolia are protected by CITES Appendix I and Russian populations are protected by Appendix II.
description: Published as part of Jo, Yeong-Seok, Baccus, John T. & Koprowski, John L., 2018, Mammals of Korea: a review of their taxonomy, distribution and conservation status, pp. 1-216 in Zootaxa 4522 (1) on page 65, DOI: 10.11646/zootaxa.4522.1.1, http://zenodo.org/record/2610198
Inhibition of TF Signaling as Novel Breast Cancer Therapy
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Activation of the blood clotting cascade and the resulting increased risk for thrombosis are well known to cancer patients. The cause of increased clotting tendency is expression of a cell surface receptor, termed tissue factor (TF), by cancer cells. Once TF comes in contact with blood, it triggers blood coagulation. Previous studies have focused on blocking the coagulation pathway in breast cancer patients. However, anticoagulant therapy increases the risk of bleeding which limits aggressive adjuvant therapy in long-term cancer care.

 It has become evident from basic research that TF can change the basic biology of cells through direct cell signaling, which is independent of its ability to trigger blood clotting. We have identified an antibody with the unique property to block direct TF signaling without altering TF-induced coagulation. This antibody also attenuates the growth of highly aggressive breast cancer tumors in mouse models. These properties suggest a novel concept to block direct signaling of TF for breast cancer therapy without any adverse effects on normal blood clotting.

 This research aims to evaluate the synergistic effects of anti-TF antibody when applied with existing anti-angiogenic, anti-growth factor and chemotherapy in a mouse model of aggressive human breast cancer. We have established an aggressive breast tumor cell line that will be “tagged” to allow tumor imaging. This new cell line will be injected into the mammary gland of immunodeficient mice together with either: (1) antibodies targeting the tumor vasculature (anti-VEGF or anti-VEGFR2), (2) our own anti-TF antibody to block signaling functions, or (3) a combination of both antibody types. In addition, we will also address the potential utility of anti-TF therapy in a chemotherapy regimen or anti-EGF (epidermal growth factor receptor) treatment (Cetuximab). We will follow the effect of the treatment with imaging techniques as well as with standard tumor measurement methods. A more in depth analysis will be performed by histology of the tumor samples collected from these experiments.

 These experiments will test the novel concept that inhibiting direct TF signaling can enhance breast cancer therapy when applied in combination with established treatment options. Establishing potential treatment synergies is a crucial next step to address the viability of such therapies in clinical breast cancer care.
Additional file 1: of Assessment of success of the Ponseti method of clubfoot management in sub-Saharan Africa: a systematic review
Creators: name: Smythe, Tracey
name: Mudariki, Debra
name: Kuper, Hannah
name: Lavy, Christopher
name: Foster, Allen
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Expanded search terms for country name in sub-Saharan Africa. (DOCX 13 kb)
Eoferreola cyrenaica
Creators: name: Gadallah, Neveen S.
name: Schmid-Egger, Christian
name: Brothers, Denis J.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Pompilidae
Eoferreola
Eoferreola cyrenaica

description: Eoferreola cyrenaica (Guiglia, 1941)
Distribution in the Arabian Peninsula: Saudi Arabia (Gadallah & El-Barty 2011).
Extralimital distribution: Egypt, Jordan, Libya, Mali, Morocco, Palestine (Guiglia 1941; Priesner 1955, 1966b; Wahis & Schmid-Egger 2002).
description: Published as part of Gadallah, Neveen S., Schmid-Egger, Christian & Brothers, Denis J., 2020, Biodiversity of the aculeate wasps (Hymenoptera: Aculeata) of the Arabian Peninsula: Vespoidea, Pompilidae, pp. 153-173 in Zootaxa 4754 (1) on page 162, DOI: 10.11646/zootaxa.4754.1.16, http://zenodo.org/record/3719039
Targeting Brain Metastasis with a Cell-based Approach
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Breast cancer patients diagnosed with brain metastases have an extremely poor prognosis since no efficient therapies are available. Brain lesions are often shielded by the blood-brain barrier (BBB) which hinders drug penetration. Furthermore, the presence of multifocal brain lesions often hinders their complete removal by surgery due to neurotoxicities. Thus, novel therapeutic concepts tailored to overcome these current limitations in the treatment of brain lesions are urgently required.

 In our mouse models of breast cancer brain metastasis we have observed a specific homing of activated microglia to cancer cells from the time point of their arrival in the brain and persisting throughout the development of macroscopic brain lesions. Microglia are the resident macrophages of the brain and spinal cord, and act as a form of immune defense in the central nervous system. Our preliminary work suggests that the majority of cancer cell-associated activated microglia originate from the inflammatory monocytes that are derived from the hematopoietic stem cells (HSC) in bone marrow. The infiltration of inflammatory monocytes into the brain is drastically increased upon the initiation of brain lesions.

 For these studies, we have established mouse models of breast cancer brain metastases in which cancer cells are injected into the carotid artery to colonize the brain from the blood stream or implanted directly into the brain itself. Our first aim is to study the role of microglial activation in these models. For this we will administer minocycline, a BBB-permeable suppressor of microglial activation, and deplete bone marrow-derived microglia using clodronate-loaded liposomes. The suppression of microglial activation and their depletion will be confirmed by pathology staining and analyzed by FACS (fluorescence activated cell sorting) using markers for microglia and inflammatory monocytes. The quantification of tumor growth over time in treated animals vs. controls will be performed by bioluminescent imaging of cancer cells. Our second aim is to determine whether genetically engineered HSC will “home” to brain tumors from the blood stream. For this we will isolate HSC, introduce a fluorescent tracer, inject them into the circulation, and determine whether they migrate to sites of breast cancer metastasis in the brain. If this strategy proofs successful, we plan to use HSC as cellular vehicles to deliver therapeutic agents to malignant brain lesions.

 Our microglia-based approaches could lead to novel therapies targeting brain metastases by overcoming the major therapeutic limitations imposed by the BBB, drug resistance, and the multifocal nature of brain lesions.
Citharomantis Rehn 1909
Creators: name: Schwarz, Christian J.
name: Konopik, Oliver
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Mantodea
Hymenopodidae
Citharomantis

description: Citharomantis Rehn, 1909
Monotypic, related to Acromantis. Arboricolous, restricted to forests.
Citharomantis falcata Rehn, 1909
Distribution. Malay Peninsula, Sumatra, N Borneo (Giglio-Tos 1915a, Werner 1922, Helmkampf et al. 2007, Bragg 2008).
Bornean records. Sarawak: Mt. Mulu (Bragg 2008); Sabah: Danum Valley (Helmkampf et al. 2007), Ulu Dusun (Bragg 2008), Labuk River (Bragg 2008), Sorinsim (AFUW), Crocker Range (AFUW).
description: Published as part of Schwarz, Christian J. & Konopik, Oliver, 2014, An annotated checklist of the praYing mantises (Mantodea) of Borneo, including the results of the 2008 scientific expedition to Lanjak Entimau Wildlife SanctuarY, Sarawak, pp. 130-168 in Zootaxa 3797 (1) on page 141, DOI: 10.11646/zootaxa.3797.1.12, http://zenodo.org/record/226038
Modern rebels
Creators: name: Pauli, Benjamin Jacob
Publisher: name: No Publisher Supplied
Year: 2014

description: This dissertation is the first sustained evaluation of postwar British and American anarchist thought. I argue that British and American anarchist intellectuals like Herbert Read, Alex Comfort, Colin Ward, Paul Goodman, and Murray Bookchin gave shape to a distinct genre of anarchist thought in the middle decades of the 20th century by adapting anarchism to non-revolutionary conditions. Their thought was both radical and reformist, utopian and pragmatic, aimed at democratizing existing institutions no less than constructing alternatives outside of the state system. It was inspired not only by “classical” anarchist thinkers like William Godwin and Peter Kropotkin, but by disciplines like psychology, sociology, and urban planning, as well as indigenous sources of radicalism like Guild Socialism and Populism. I show how these figures made anarchism relevant to the most pressing social and political issues of the postwar world: the rise of the “managerial” welfare state, the threat of nuclear annihilation, the influence of mass culture and mass education on a growing middle class, and burgeoning concerns about environmental destruction. Their thought pointed towards a new approach to political practice, giving theoretical expression to the “intuitive” anarchism of new social movements like the nuclear disarmament and pacifist movements, the student movement, the ecology movement, and the community control movement. By revealing the political thought of the New Anarchists to be a coherent and inventive body of ideas, I overturn the common belief that the postwar era was unproductive for anarchist theory.
Additional file 1: of Am I getting an accurate picture: a tool to assess clinical handover in remote settings?
Creators: name: Moore, Malcolm
name: Roberts, Chris
name: Newbury, Jonathan
name: Crossley, Jim
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology

description: Semi-structured interview: RFDS doctors. Question list. (DOCX 14Â kb)
Episyron anticum
Creators: name: Gadallah, Neveen S.
name: Schmid-Egger, Christian
name: Brothers, Denis J.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Pompilidae
Episyron
Episyron anticum

description: Episyron anticum (Klug, 1834)
Distribution in the Arabian Peninsula: Saudi Arabia (Abu Zoherah et al. 1993 as Pompilus anticus).
Extralimital distribution: Algeria, Egypt, Israel (Priesner 1966a).
description: Published as part of Gadallah, Neveen S., Schmid-Egger, Christian & Brothers, Denis J., 2020, Biodiversity of the aculeate wasps (Hymenoptera: Aculeata) of the Arabian Peninsula: Vespoidea, Pompilidae, pp. 153-173 in Zootaxa 4754 (1) on page 162, DOI: 10.11646/zootaxa.4754.1.16, http://zenodo.org/record/3719039
Bodenlagerung in Beziehung zu Kalkabscheidung und Fossilführung beim "Böttinger Marmor" (Schwäbische Alb, SW-Deutschland)
Creators: name: Bleich, Klaus Eberhard
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1998

description: Jahreshefte der Gesellschaft für Naturkunde in Württemberg
description: 154
Thermal reaction of anisaldehyde in the presence of l-cysteine, a model reaction of Chinese stew meat flavor generation
Creators: name: Pu, Xu
Publisher: name: No Publisher Supplied
Year: 2014

description: Chinese stew meat is very popular in China due to its special flavor generated during cooking process. However, how these flavors are produced has not been studied yet. Star anise is one of the indispensable ingredients in the formation of Chinese stewed meat flavor. One of the most important volatile components in star anise is anisaldehyde. Anisaldehyde may react with sulfur-containing constituents of meat such as cysteine to form components of sensory significant during the cooking of stewed meat. Cysteine is major precursor for meat flavor generation.    We present here results of a study that tested the thermal reaction of anisaldehyde in the presence of cysteine under certain conditions. Anisaldehyde was mixed with cysteine, then the mixture was heated to both 60℃, 80℃, 120℃ and 150℃ for two hours by oil bath. To determine both volatile and non-volatile compounds, products were separated into two parts. In order to detect non-volatile compounds, one part of the products was extracted by ethyl acetate. One major non-volatile product was purified from the sample by HPLC. Mass spectrometry was used to determine the structure of that major non-volatile compound, which is identified as 4-methoxybenzothialdehyde. For volatile compound detection, the other part of the product was extracted by dichloromethane and the volatile compounds were then determined by using GC/MS. Several major sulfur containing aroma compounds were identified besides various products generated during cysteine thermal degradation. Detection for both volatile and non-volatile compounds indicates that anisaldehyde can react with cysteine and may influence the meat flavor generation during the Chinese stew meat cooking process.
Ursus thibetanus G. Cuvier 1823
Creators: name: Jo, Yeong-Seok
name: Baccus, John T.
name: Koprowski, John L.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Carnivora
Ursidae
Ursus
Ursus thibetanus

description: Ursus thibetanus G. [Baron] Cuvier, 1823 —Asian Black Bear
Ursus thibetanus G. Cuvier, 1823 p.325; Type locality- Assam, India; Won, 1968 p.276; Han, 1994 p.46; Won & Smith, 1999 p.17.
Selenarctos ussuricus Heude, 1901 p.2; Type locality- Ussuri, Russia.
S. thibetanus wulsini Howell, 1928 p.115; Type locality- Chihli, Hebei, China (not Chiri/or Jiri, Korea; often, Korean bear scientists confused Chiri with Chihli).
U. ussuricus: Kishida & Mori, 1931 p.379.
U. thibetanus ussuricus: Kuroda, 1939 p.32; Won, 1958 p.440; Won, 1967 p.127; Won, 1968 p.277.
S. thibetanus ussuricus: Ellerman & Morrison-Scott, 1951 p.239; Yoon, 1992 p.98.
S. thibetanus: Oh, 2004a p.162.
Range: Despite unofficial reports of Asian black bears, wild populations in South Korea can be considered extirpated. However, bear farms now exist throughout the country, and several bears from these farms escape every year. A restoration project with nonindigenous bears implemented in 2001 at Mt. Jiri National Park had limited success. A natural population of black bears existed on Mt. Myohyang in the 2000s and even the isolated and heavily human-populated Mt. Guwol had a population (W. Duckworth, IUCN, 2015, pers. comm.). Populations of black bears also reside in the Mt. Baekdu and Mt. Geumgang areas of North Korea (Kim et al. 2015; Fig. 41).
Remarks: The subspecific name of black bears in the Korean Peninsula has traditionally been U. t. ussuricus Heude, 1901, Ussuri black bear.
Conservation status: The South Korean Government designated the Asian black bear as a Natural Monument in 1982 and an endangered species in 1997. For the recovery project in South Korea, bears were released in 2001 from a bear farm near Seoul. These bears had a recall in 2004 due to a dispute about their origin. Since 2004, bears from a bear orphanage in Russia, bears from a bear farm in China, and bears from Pyongyang Zoo in North Korea have been released. According to genetic analysis, these three sources belonged to the same subspecies (U. t. ussuricus) as the indigenous inhabitant of Korea (Kim et al. 2011b). The NIBR (2012) considered South Korean populations as ‘Endangered’, and North Korea classified this species as ‘Vulnerable’. Ursus thibetanus is also protected by CITES Appendix I.
description: Published as part of Jo, Yeong-Seok, Baccus, John T. & Koprowski, John L., 2018, Mammals of Korea: a review of their taxonomy, distribution and conservation status, pp. 1-216 in Zootaxa 4522 (1) on pages 65-66, DOI: 10.11646/zootaxa.4522.1.1, http://zenodo.org/record/2610198
Side view and end view mixing measurements of a sonic transverse jet in a supersonic crossflow
Creators: name: Pizzaia, Adam R.
Publisher: name: No Publisher Supplied
Year: 2014

description: The primary investigation was to determine if mixing of a sonic transverse jet in the side-view plane was correlated to or equal to the mixing in the end-view plane. The analysis was conducted by imaging a sonic jet in a supersonic crossflow at jet momentum ratios of 1.2, 2.&, and 5.2. Because of the difficulty of placing a camera streamwise to a supersonic crossflow to obtain end view images, off axis imaging was carried out. Overall, the jets appear to be more symmetric when injected into the thin boundary layer than in the thick boundary layer. Centerline probability density functions in the end view plane were compared with probability density functions in the side view plane. The probability of finding unmixed fluid at the windward side of the jet was higher than finding unmixed fluid toward the center or near the orifice plane.  Different paths other than those that fall on the mid planes were analyzed and compared in the end-view plane. The effect of the boundary layer thickness on the penetration and mixing of the sonic jet in supersonic flow was investigated.
Heliomantis Giglio-Tos 1915
Creators: name: Schwarz, Christian J.
name: Konopik, Oliver
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Mantodea
Hymenopodidae
Heliomantis

description: Heliomantis Giglio-Tos, 1915
= Paraspilota Bolívar, 1914
= Deiroharpax Werner, 1916
Related to Anaxarcha and Odontomantis, with one Indian and one Bornean species. Arboricolous.
Heliomantis latipennis Werner, 1930
Distribution. NE Sarawak: Mt. Murud (Werner 1930).
description: Published as part of Schwarz, Christian J. & Konopik, Oliver, 2014, An annotated checklist of the praYing mantises (Mantodea) of Borneo, including the results of the 2008 scientific expedition to Lanjak Entimau Wildlife SanctuarY, Sarawak, pp. 130-168 in Zootaxa 3797 (1) on page 142, DOI: 10.11646/zootaxa.3797.1.12, http://zenodo.org/record/226038
MOESM3 of Active fraction (HS7) from Taiwanofungus camphoratus inhibits AKT-mTOR, ERK and STAT3 pathways and induces CDK inhibitors in CL1-0 human lung cancer cells
Creators: name: I-Chun Lai
name: Gi-Ming Lai
name: Jyh-Ming Chow
name: Hsin-Lun Lee
name: Yeh, Chuan-Feng
name: Chi-Han Li
name: Jiann-Long Yan
name: Shuang-En Chuang
name: Whang-Peng, Jacqueline
name: Kuan-Jen Bai
name: Chih-Jung Yao
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 3. Apoptosis induction in CL1-0 lung cancer cells by HS7 at dose of 50Â Îźg/mL.
Erstnachweis von Psilophyllites hagenowi (Ammonoidea) im Schwarzen Jura Alpha 1 (Hettangium, Unterer Lias) von Ostwürttemberg
Creators: name: Bloos, Gert
name: Gräbenstein, Stefan
name: Werner, Günther
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1998

description: Jahreshefte der Gesellschaft für Naturkunde in Württemberg
description: 154
Milk-borne bioactive factors
Creators: name: Rahman, Kathleen M.
Publisher: name: No Publisher Supplied
Year: 2014

description: Milk-borne bioactive factors (MbFs) are delivered to nursing offspring via a lactocrine mechanism to affect development of somatic tissues, including the uterus. In the pig, lactocrine-sensitive events associated with postnatal uterine development between birth (postnatal day = PND 0) and PND 2 define the developmental program and can determine developmental trajectory and function. However, lactocrine-sensitive elements of the neonatal porcine uterine transcriptome have not been defined during this period. The extent to which MbFs, including insulin-like growth factor (IGF)-I, affect development of the porcine uterus postnatally is unknown. Furthermore, whether nursing supports testicular development in pigs by PND 2 remains to be determined. Research goals were to (1) define the lactocrine-sensitive uterine transcriptome in  nursed gilts compared to animals fed replacer from birth until PND 2; (2) determine whether feeding colostrum, with or without IGF-I supplementation, supports endometrial cell proliferation at 12 h postnatal; and (3) assess whether nursing affects Sertoli and Leydig cell development as well as expression of markers important for testicular development within two days after birth. Results showed that in uteri of nursed as compared to replacer-fed gilts, 896 genes were differentially expressed and multiple elements of biological processes and pathways affected by PND 2. Additionally, data indicated that when compared to replacer-fed gilts, a single dose of colostrum at birth increased endometrial cell proliferation at 12 h postnatal. Furthermore, oral IGF-I increased uterine cell proliferation when co-administered with replacer, but not with colostrum. Sertoli cell number and proliferation were increased in boars nursed for two days compared to newborn or replacer-fed boars at PND 2. However, testicular RXFP1 expression was increased in replacer-fed animals as compared to boars collected at birth or after two days of nursing. Collectively, data presented here reinforce and extend previous findings that lactocrine signaling supports neonatal porcine reproductive development. Results can be used to refine and focus the lactocrine hypothesis to identify key MbFs as well as cellular and molecular mechanisms that regulate postnatal male and female reproductive development in the pig.
Episyron arnoldi Priesner 1966
Creators: name: Gadallah, Neveen S.
name: Schmid-Egger, Christian
name: Brothers, Denis J.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Pompilidae
Episyron
Episyron arnoldi

description: Episyron arnoldi Priesner, 1966
Distribution in the Arabian Peninsula: United Arab Emirates (Schmid-Egger 2017).
Extralimital distribution: Algeria, Egypt, Sudan (Priesner 1966a; Wolf 1983).
description: Published as part of Gadallah, Neveen S., Schmid-Egger, Christian & Brothers, Denis J., 2020, Biodiversity of the aculeate wasps (Hymenoptera: Aculeata) of the Arabian Peninsula: Vespoidea, Pompilidae, pp. 153-173 in Zootaxa 4754 (1) on page 162, DOI: 10.11646/zootaxa.4754.1.16, http://zenodo.org/record/3719039
Episyron rufipes
Creators: name: Gadallah, Neveen S.
name: Schmid-Egger, Christian
name: Brothers, Denis J.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Pompilidae
Episyron
Episyron rufipes

description: Episyron rufipes (Linnaeus, 1758)
Distribution in the Arabian Peninsula: Saudi Arabia (Gadallah & El-Barty 2011; Loktionov & Lelej 2017a), Yemen (Wahis 2002; Loktionov & Lelej 2017a).
Extralimital distribution: All Europe, Iran, Jordan, Ethiopia, Kazakhstan, Kyrgyzstan, North Africa, Russia (from European part to Sakhalin and Kamchatka in the East), Sudan, Syria, Turkey, Turkmenistan, Uzbekistan (Junco y Reyes 1963; Priesner 1966a; Day 1988; Wolf 1997, 1998c, 2005; Wahis 2002; Zonstein 2002; Ebrahimi et al. 2008; Yildirim & Wahis 2011; Loktionov & Lelej 2017a).
description: Published as part of Gadallah, Neveen S., Schmid-Egger, Christian & Brothers, Denis J., 2020, Biodiversity of the aculeate wasps (Hymenoptera: Aculeata) of the Arabian Peninsula: Vespoidea, Pompilidae, pp. 153-173 in Zootaxa 4754 (1) on page 162, DOI: 10.11646/zootaxa.4754.1.16, http://zenodo.org/record/3719039
High Resolution Studies of the Full Length HIV-1 Env Trimer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Ever since the introduction of human immunodeficiency virus (HIV) into the human population around 50 years ago, it has become a persistent pandemic infecting millions of people worldwide. As of now there is no cure for HIV/AIDS, and the available treatments that help alleviate symptoms and prolong life are not readily accessible to the majority of HIV patients living in third world countries. In order to curb the epidemic, researchers have conducted over 30 clinical trials with vaccine candidates since 1987, albeit without success. Vaccines work by training the immune system against viral proteins prior to infection, such that it readily produces antibodies that recognize the foreign viral component upon infection. In HIV, this antigen is called the envelope glycoprotein (Env), which forms a trimeric spike embedded on the viral membrane on the surface of the virus, where each of the three pillars within the trimer consists of two protein components, gp120 and gp41. The failure in vaccine development has been due to the numerous tactics employed by HIV to escape the surveillance by immune system. These include gp120 shedding which reduces the number of spikes available for recognition by the immune system, a shield of carbohydrates around gp120 that makes it look less foreign, and high mutation rates resulting in a lack of a consistent target for antibodies produced. The recent fortuitous discovery of broadly neutralizing antibodies (bNAbs) that are able to potently disable diverse HIV strains lead to the idea of engineering an Env based vaccine that is able to elicit the same bNAb responses. In order to illustrate how bNAbs interact with Env, I will utilize electron microscopy (EM) to take high magnification pictures of Env-antibody complexes. From these 2D images I will use computational methods to create 3D models showing how these proteins interact. Because many of the previous structural studies of Env proteins have only visualized small fragments, I will focus my studies on the full length protein in its native membrane environment. The models generated from these studies will provide hints as to which regions of Env are the most vulnerable and why, what specific shape Env has to assume for recognition by antibodies to be possible, and how these antibodies neutralize HIV activity by binding to Env. The knowledge garnered from structural studies can aid in the design of an Env protein that behaves and is recognized by the immune system in a manner able to drive antibody response upon future infection.
Der Nusplinger Plattenkalk (Weißer Jura Zeta) - Grabungskampagne 1997
Creators: name: Dietl, Gerd
name: Kapitzke, Martin
name: Rieter, Markus
name: Hugger, Rolf
name: Schweigert, Günter
name: Zügel, Peter
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1998

description: Jahreshefte der Gesellschaft für Naturkunde in Württemberg
description: 154
Mustelidae Fischer 1817
Creators: name: Jo, Yeong-Seok
name: Baccus, John T.
name: Koprowski, John L.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Carnivora
Mustelidae

description: Family MUSTELIDAE Fischer, 1817
Since the exclusion of the Mephitidae, Wozencraft (2005) recognized two Subfamilies, Lutrinae and Mustelinae within the Family Mustelidae. Four genera and nine species of mustelids occur in Korea.
description: Published as part of Jo, Yeong-Seok, Baccus, John T. & Koprowski, John L., 2018, Mammals of Korea: a review of their taxonomy, distribution and conservation status, pp. 1-216 in Zootaxa 4522 (1) on page 67, DOI: 10.11646/zootaxa.4522.1.1, http://zenodo.org/record/2610198
Source apportionment of polychlorinated biphenyls in New Jersey air and Delaware river sediments
Creators: name: Praipipat, Pornsawai
Publisher: name: No Publisher Supplied
Year: 2014

description: Polychlorinated Biphenyls (PCBs) are chlorinated organic compounds that are classified as toxic, bioaccumulative, and persistent in the environment. Although the commercial production and use of PCBs was banned in the late 19&0s, PCBs are ubiquitous in the environment as they cycle through air, water, soil, and sediment at levels that often exceed applicable environmental standards. The purpose of this dissertation was to identify PCB sources to the sediments of the Delaware River and the air of the New Jersey/Delaware River basin region. This was accomplished in part by analyzed existing data sets via a source apportionment tool called positive matrix factorization (PMF). In Delaware River sediment (Chapter 2), PMF resolved seven factors. Three were unweathered Aroclors, two were non-Aroclor sources related to pigment use and production, and the remaining two were probably originally related to Aroclors but were highly weathered.            PMF was also applied to data from the Delaware Atmospheric Deposition Network (DADN) collected in Camden (1999-2011) and New Brunswick (199&-2011) (Chapter 3). PMF resolved four factors at each site. The factors that dominate PCB burden in the atmosphere at both sites resemble unaltered Aroclor 1242 and vaporized Aroclor 1248. During 2004-2011, only one of the eight factors was declining. All others were unchanged or increasing. This suggests natural attenuation alone will not control atmospheric PCB concentrations, and additional efforts are needed to control PCB emissions. Moreover, the Total Maximum Daily Loads promulgated for PCBs in the tidal Delaware River are not achievable in the foreseeable future due to continuing atmospheric deposition.            In Chapter 4, PCBs 4 and PCB 11 were measured by reanalyzing the original gas-phase DADN samples from Camden, New Brunswick, and Lums Pond. To ensure that these dichlorobiphenyl congeners can be accurately quantified in these samples, a careful study of the breakthrough of PCBs when using polyurethane foam (PUF) as a sorbent for high-volume air sampling was performed. Gas-phase concentrations of PCB 11 ranged from non-detect to 146 pg m-3 and did not display a strong urban to rural gradient. PCB 4 concentrations ranged from 0.18 to 168 pg m-3 and were highest at Camden.
Psychomantis Giglio-Tos 1915
Creators: name: Schwarz, Christian J.
name: Konopik, Oliver
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Mantodea
Hymenopodidae
Psychomantis

description: Psychomantis Giglio-Tos, 1915
Closely resembling Acromantis, with two Sunda species (Beier 1931a). Arboricolous, prefers primary forest.
Psychomantis borneensis (De Haan, 1842)
Mantis borneensis De Haan, 1842: 91
Distribution. Borneo, Sumatra (Werner 1922, Ehrmann 2002; AFUW, SMNK).
Bornean records. Sarawak: Lanjak Entimau (2 m, 1 f, CSUB/SFDC), Mt. Dulit (Beier 1937), Mt. Mulu (CS in situ); Brunei: Kuala Belalong (OK in situ); Sabah: Malinau (Giglio-Tos 1915a), Poring Hot Springs (Helmkampf et al. 2007; SMNK), Sorinsim (AFUW), Danum Valley (CSUB), Maliau Basin (OK in situ); Kalimantan: Sakoembang (De Haan, 1842), Boentok (Giglio-Tos, 1915a), Moan (Beier 1958), Sambas (Werner 1922), Waisi (Beier 1958).
description: Published as part of Schwarz, Christian J. & Konopik, Oliver, 2014, An annotated checklist of the praYing mantises (Mantodea) of Borneo, including the results of the 2008 scientific expedition to Lanjak Entimau Wildlife SanctuarY, Sarawak, pp. 130-168 in Zootaxa 3797 (1) on page 142, DOI: 10.11646/zootaxa.3797.1.12, http://zenodo.org/record/226038
A comparative study of familial racial socialization and its impact on black/white biracial siblings
Creators: name: Porow, Monique Anne
Publisher: name: No Publisher Supplied
Year: 2014

description: This dissertation examines the nature of racial socialization within the families of biracial people. Unlike previous studies of racial socialization of children with one Black and one White parent, this project broadens the scope of influential agents of racial socialization. Utilizing an inclusive approach, I examine the role that parents, extended family members, and siblings play in the process of shaping the racial identity development of biracial people. Through the use of a grounded theory approach, I draw upon data from 22 qualitative, semi-structured interviews with people who have one Black and one White parent. I utilize their responses to questions regarding the nature of their relationship with various family members, and the impact of those experiences. The 22 respondents included in this study composed 10 sibling sets: 8 dyads and 2 triads. This comparative sibling design provides a context ripe with information about the family inaccessible through other study designs. Employing this sibling study, I elucidate the nature of messages conveyed regarding race, from various members of the family, and I theorize these complex and overlooked processes of racial socialization. I outline agent-specific mechanisms of racial socialization within the family illustrating that parents are not the only influential agents as extant literature would suggest. I argue that all members of the family can be influential agents when engaging agent-specific mechanisms of racial socialization. Those mechanisms include: parents acting as direct and strategic agents of racial socialization, extended family members acting as indirect cultivators of group-belonging or exclusion, and sibling ancillary support to biracial people negotiating and developing their racial identities. There is an interconnectedness of influence that results from these various approaches to racial socialization. I conceptualize these complex and agent-specific mechanisms, through a figure called the Family Nexus of Racial Socialization. This concept enhances our present understanding of how various family members engage in racial socialization, and the interconnectedness of their influence.
Benthic index development: Assessment of ecological status of benthic communities in New Jersey marine coastal waters
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 2011

description: This report describes the development of a biotic index using macrofaunal benthic communities designed to assess the ecological condition of nearshore ocean waters along the New Jersey coast. It was compiled as part of the New Jersey Department of Environmental Protection’s (NJDEP) benthic indicators project with the goal of implementing ecosystem-based management in New Jersey's coastal waters.
Additional file 3: of The ICU-Diary study: prospective, multicenter comparative study of the impact of an ICU diary on the wellbeing of patients and families in French ICUs
Creators: name: Maïté Garrouste-Orgeas
name: Flahault, Cécile
name: Fasse, Léonor
name: Ruckly, Stéphane
name: Amdjar-Badidi, Nora
name: Argaud, Laurent
name: Badie, Julio
name: Bazire, Amélie
name: Naike Bige
name: Boulet, Eric
name: Bouadma, Lila
name: Bretonnière, Cédric
name: Floccard, Bernard
name: Gaffinel, Alain
name: Forceville, Xavier De
name: Grand, Hubert
name: Halidfar, Rebecca
name: Olfa Hamzaoui
name: Mercé Jourdain
name: Paul-Henri Jost
name: Kipnis, Eric
name: Large, Audrey
name: Lautrette, Alexandre
name: Lesieur, Olivier
name: Maxime, Virginie
name: Mercier, Emmanuelle
name: Mira, Jean
name: Monseau, Yannick
name: Parmentier-Decrucq, Erika
name: Jean-Philippe Rigaud
name: Rouget, Antoine
name: Santoli, François
name: Simon, Georges
name: Tamion, Fabienne
name: Thieulot-Rolin, Nathalie
name: Thirion, Marina
name: Valade, Sandrine
name: Vinatier, Isabelle
name: Vioulac, Christel
name: Bailly, Sebastien
name: Jean-François Timsit
Publisher: name: Figshare
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Participants’ centers. (DOCX 13 kb)
Vulnerability of &0 plant species of greatest conservation need to climate change in New Jersey
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 2013

description: In order to better integrate the conservation of plant species into the New Jersey State Wildlife Action Plan, this analysis of the vulnerability to climate change of seventy plant Species of Greatest Conservation Need in New Jersey was initiated.  The Climate Change Vulnerability Index bases its determination of vulnerability to climate change on two main components: exposure to future projected climate change and sensitivity to climate change, and scores various factors related to each of these.
Lutra Brisson 1762
Creators: name: Jo, Yeong-Seok
name: Baccus, John T.
name: Koprowski, John L.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Carnivora
Mustelidae
Lutra

description: Genus Lutra Brisson, 1762
This genus represents the Subfamily Lutrinae and has three recognized species: Lutra lutra occupies most of Eurasia, L. sumatrana occurs in southeastern Asia, and the extinct L. nippon was endemic to Japan. A single species, L. lutra lives throughout the Korean Peninsula and littoral islands.
description: Published as part of Jo, Yeong-Seok, Baccus, John T. & Koprowski, John L., 2018, Mammals of Korea: a review of their taxonomy, distribution and conservation status, pp. 1-216 in Zootaxa 4522 (1) on page 68, DOI: 10.11646/zootaxa.4522.1.1, http://zenodo.org/record/2610198
Episyron histrio
Creators: name: Gadallah, Neveen S.
name: Schmid-Egger, Christian
name: Brothers, Denis J.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Pompilidae
Episyron
Episyron histrio

description: Episyron histrio (Lepeletier, 1845)
Distribution in the Arabian Peninsula: Yemen (Kohl 1906 as Pompilus histrio; Wahis 2000a).
Extralimital distribution: Democratic Republic of Congo, Ethiopia, Mali, South Africa, Zimbabwe (Arnold 1936; Picker et al. 2002).
description: Published as part of Gadallah, Neveen S., Schmid-Egger, Christian & Brothers, Denis J., 2020, Biodiversity of the aculeate wasps (Hymenoptera: Aculeata) of the Arabian Peninsula: Vespoidea, Pompilidae, pp. 153-173 in Zootaxa 4754 (1) on page 162, DOI: 10.11646/zootaxa.4754.1.16, http://zenodo.org/record/3719039
Integrated management guidelines for four habitats and associated state endangered plants and wildlife species of greatest conservation need in the Skylands and Pinelands landscape conservation zones of the New Jersey state wildlife action plan
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 2013

description: The purpose of this project is to develop rare plant conservation strategies that complement conservation actions for animal species in the context of biodiversity protection and climate change in New Jersey. The project focused on two high-priority regions of the state with the development of a spatial framework and conservation strategy prototype that can be used in other regions of the state.
Die Massen- und Bankkalke bei Geislingen/Steige (Kimmeridge, östl. Schwäbische Alb) - Mikrofazies, Ablagerungsraum und diagnetische Entwicklung
Creators: name: Reinhold, Carsten
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1998

description: Jahreshefte der Gesellschaft für Naturkunde in Württemberg
description: 154