title: ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÐ¾Ð»Ð¸ Ð½ÐµÐ¹ÑÐ¾Ð²Ð¾ÑÐ¿Ð°Ð»ÐµÐ½Ð¸Ñ Ð² Ð¿Ð°ÑÐ¾Ð³ÐµÐ½ÐµÐ·Ðµ ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ð¸ Ð½Ð° Ð¼Ð¾Ð´ÐµÐ»Ð¸ ÐºÑÑÑ ÐÑÑÑÐ¸Ð½ÑÐºÐ¾Ð³Ð¾-ÐÐ¾Ð»Ð¾Ð´ÐºÐ¸Ð½Ð¾Ð¹
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Investigation of the role of neuroinflammation in the pathogenesis of epilepsy on the model of Krushinsky-Molodkina rats
Creators: name: ÐÐ¸ÑÐµÐ½ÐºÐ¾Ð²Ð°, ÐÐ°ÑÑÑ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2023
Subjects: ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ñ
Ð½ÐµÐ¹ÑÐ¾Ð²Ð¾ÑÐ¿Ð°Ð»ÐµÐ½Ð¸Ðµ
Ð°Ð¿Ð¾Ð¿ÑÐ¾Ð·
fas
fasl
caspase-8
p105
epilepsy
neuroinflammation
apoptosis

description: ÐÐ¾Ð¸ÑÐº Ð½Ð¾Ð²ÑÑ ÑÐµÑÐ°Ð¿ÐµÐ²ÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¼Ð¸ÑÐµÐ½ÐµÐ¹ Ð¸ Ð¿Ð¾Ð´ÑÐ¾Ð´Ð¾Ð² Ðº Ð»ÐµÑÐµÐ½Ð¸Ñ ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ð¸ ÑÐ²Ð»ÑÐµÑÑÑ Ð°ÐºÑÑÐ°Ð»ÑÐ½ÑÐ¼ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸ÐµÐ¼ Ð² ÑÑÐµÑÐµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¹ Ð½ÐµÐ²ÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ð¹.Â  Â  Â  Â  Â  Â  ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð±ÐµÐ»ÐºÐ¾Ð², ÑÑÐ°ÑÑÐ²ÑÑÑÐ¸Ñ Ð² Ð°Ð¿Ð¾Ð¿ÑÐ¾Ð·Ðµ, Fas, FasL (CD178), Ñaspase-8 Ð¸ Ð±ÐµÐ»ÐºÐ° Ð¸Ð¼Ð¼ÑÐ½Ð½Ð¾Ð³Ð¾ Ð¾ÑÐ²ÐµÑÐ° NF-kB (p105) Ð² ÐºÐ¾ÑÐµ Ð²Ð¸ÑÐ¾ÑÐ½Ð¾Ð¹ Ð´Ð¾Ð»Ð¸ Ð³Ð¾Ð»Ð¾Ð²Ð½Ð¾Ð³Ð¾ Ð¼Ð¾Ð·Ð³Ð° Ð¸ Ð¸Ñ ÑÐ¾Ð»Ð¸ Ð² Ð½ÐµÐ¹ÑÐ¾Ð²Ð¾ÑÐ¿Ð°Ð»ÐµÐ½Ð¸Ð¸, Ð²Ð¾Ð·Ð½Ð¸ÐºÐ°ÑÑÐµÐ¼ Ñ ÐºÑÑÑ Ð¿Ð¾ÑÐ»Ðµ Ð°ÑÐ´Ð¸Ð¾Ð³ÐµÐ½Ð½Ð¾Ð¹ ÑÑÐ¸Ð¼ÑÐ»ÑÑÐ¸Ð¸ ÑÑÐ´Ð¾ÑÐ¾Ð¶Ð½ÑÑ Ð¿ÑÐ¸Ð¿Ð°Ð´ÐºÐ¾Ð². ÐÑÐ»Ð¾ Ð²ÑÑÐ²Ð»ÐµÐ½Ð¾ Ð¿Ð¾Ð²ÑÑÐµÐ½Ð¸Ðµ ÑÑÐ¾Ð²Ð½Ñ Ð±ÐµÐ»ÐºÐ¾Ð² FasL, caspase-8, p105 Ñ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑ Ð»Ð¸Ð½Ð¸Ð¸ ÐÑÑÑÐ¸Ð½ÑÐºÐ¾Ð³Ð¾-ÐÐ¾Ð»Ð¾Ð´ÐºÐ¸Ð½Ð¾Ð¹ Ð¿Ð¾ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ñ Ñ Ð³ÑÑÐ¿Ð¿Ð°Ð¼Ð¸ ÐºÐ¾Ð½ÑÑÐ¾Ð»Ñ. ÐÑÐ¾Ð¼Ðµ ÑÐ¾Ð³Ð¾, c Ð¿Ð¾Ð¼Ð¾ÑÑÑ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° TUNEL Ð±ÑÐ»Ð¾ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð½Ð¾, ÑÑÐ¾ Ð² Ð³ÑÑÐ¿Ð¿Ðµ ÐºÑÑÑ, Ð¿ÑÐ¾ÑÐµÐ´ÑÐ¸Ñ ÑÑÑÑÐ½ÐµÐ´ÐµÐ»ÑÐ½ÑÑ Ð¿ÑÐ¾ÑÐµÐ´ÑÑÑ ÐºÐ¸Ð½Ð´Ð»Ð¸Ð½Ð³Ð°, Ð½Ð°Ð±Ð»ÑÐ´Ð°Ð»Ð°ÑÑ Ð¿Ð¾Ð²ÑÑÐµÐ½Ð½Ð°Ñ Ð³Ð¸Ð±ÐµÐ»Ñ Ð½ÐµÐ¹ÑÐ¾Ð½Ð¾Ð² ÐºÐ¾ÑÑ. Ð­ÐºÑÐ¿ÑÐµÑÑÐ¸Ñ caspase-8 Ð±ÑÐ»Ð° Ð¿Ð¾Ð²ÑÑÐµÐ½Ð° Ñ Ð³ÑÑÐ¿Ð¿Ñ ÐÐ Ð¿Ð¾ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ñ Ñ ÐÐÐ,Â  ÑÑÐ¾Ð²ÐµÐ½Ñ Fas Ð±ÑÐ» Ð¿Ð¾Ð²ÑÑÐµÐ½ Ñ ÐÐÐ Ð¿Ð¾ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ñ Ñ ÐÐ¸ÑÑÐ°Ñ. Ð¢Ð°ÐºÐ¸Ð¼ Ð¾Ð±ÑÐ°Ð·Ð¾Ð¼, Ð¼Ñ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð»Ð¸, ÑÑÐ¾ ÑÑÐ¾Ð²Ð½Ð¸ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð¸ÑÑÐ»ÐµÐ´ÑÐµÐ¼ÑÑ Ð±ÐµÐ»ÐºÐ¾Ð² Ð¼Ð¾Ð³ÑÑ ÐºÐ¾ÑÑÐµÐ»Ð¸ÑÐ¾Ð²Ð°ÑÑ Ñ Ð´Ð»Ð¸ÑÐµÐ»ÑÐ½Ð¾ÑÑÑÑ ÐºÐ¸Ð½Ð´Ð»Ð¸Ð½Ð³Ð°, ÐºÑÐ¾Ð¼Ðµ ÑÐ¾Ð³Ð¾, Ð¼Ð¾Ð¶Ð½Ð¾ Ð³Ð¾Ð²Ð¾ÑÐ¸ÑÑ Ð¾ Ð³ÐµÐ½ÐµÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¾ÑÐ»Ð¸ÑÐ¸ÑÑ Ð² ÑÑÐ¾Ð²Ð½Ðµ Ð±ÐµÐ»ÐºÐ¾Ð² Ñ Ð»Ð¸Ð½Ð¸Ð¸ ÐÐ Ð¸ ÐÐ¸ÑÑÐ°Ñ.
description: Topic of the final qualification work: "Investigation of the role of neuroinflammation in the pathogenesis of epilepsy on the model of Krushinsky-Molodkina rats" The search for new therapeutic targets and approaches to the treatment of epilepsy is an important area in the field of neurological disease research. This work is devoted to the study of the expression of proteins involved in apoptosis Fas, FasL (CD178), caspase-8, and the immune response protein NF-kB (p105) in the temporal cortex of the brain and their role in neuroinflammation that occurs in rats after audiogenic stimulation of seizures. An increase in the level of FasL, caspase-8, p105 proteins was found in experimental animals of the Krushinsky-Molodkina line compared with control groups. In addition, using the TUNEL analysis, it was shown that in the group of rats that underwent a three-week kindling procedure, increased death of cortical neurons was observed. The expression of caspase-8 was increased in the Wistar group compared to KMK, the level of Fas was increased in KMK compared to Wistar. Thus, we have shown that the levels of expression of the studied proteins can correlate with the duration of kindling; in addition, we can talk about genetic differences in the level of proteins in the KM and Wistar lines.