cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Targeting centrosome amplification in aneuploid B-cell precursor acute lymphoblastic leukemia
Creators: name: Guo, Meiyun
Publisher: name: University of British Columbia
Year: 2020

description: B-cell precursor acute lymphoblastic leukemia (B-ALL) remains the single largest contributor to relapse in the pediatric leukemia patient population and new treatments are sorely needed to address this clinical challenge. Centrosomes play an important role in cell division, and centrosome abnormalities are a common feature in cancer cells. Mitotic cells with centrosome amplification are likely to form multipolar spindles, which generally lead to cell death. Cancer cells, therefore, must cluster supernumerary centrosomes to form pseudo-bipolar mitotic spindles and maintain cancer cell viability. My study investigates the efficacy of emerging inhibitors of centrosome clustering as new therapies to target pediatric B-ALL cells. As normal cells do not need to use centrosome clustering pathways, these inhibitors have the potential for low toxicity to healthy and growing tissues. However, tumor cells often resist targeted therapies and it is prudent to expect tumor adaption. My study shows that centrosome clustering inhibitors induce genetic and genomic instability in refractory leukemia cells, including micronuclei, which localize the DNA sensor cGAS and increase production of pro-inflammatory signals. Thus, refractory tumor cells may be immunogenic and activate an innate immune response. Overall, these findings identify centrosome clustering inhibitors as potential therapies to kill tumor cells and condition an immunogenic population that may be targeted by immune-based therapies to achieve long-term immune protection.
Stochastic blockmodels with growing number of classes
Creators: name: Choi, David S.
name: Wolfe, Patrick J.
name: Airoldi, Edoardo M.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Statistics Theory (math.ST)
subject: Social and Information Networks (cs.SI)
subject: Methodology (stat.ME)
subject: Machine Learning (stat.ML)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences

description: We present asymptotic and finite-sample results on the use of stochastic blockmodels for the analysis of network data. We show that the fraction of misclassified network nodes converges in probability to zero under maximum likelihood fitting when the number of classes is allowed to grow as the root of the network size and the average network degree grows at least poly-logarithmically in this size. We also establish finite-sample confidence bounds on maximum-likelihood blockmodel parameter estimates from data comprising independent Bernoulli random variates; these results hold uniformly over class assignment. We provide simulations verifying the conditions sufficient for our results, and conclude by fitting a logit parameterization of a stochastic blockmodel with covariates to a network data example comprising a collection of Facebook profiles, resulting in block estimates that reveal residual structure.
description: 12 pages, 3 figures; revised version
Random, blocky and alternating ordering in supramolecular polymers of chemically bidisperse monomers
Creators: name: Jabbari-Farouji, Sara
name: van der Schoot, Paul
Publisher: name: arXiv
Year: 2010
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: As a first step to understanding the role of molecular or chemical polydispersity in self-assembly, we put forward a coarse-grained model that describes the spontaneous formation of quasi-linear polymers in solutions containing two self-assembling species. Our theoretical framework is based on a two-component self-assembled Ising model in which the bidispersity is parameterized in terms of the strengths of the binding free energies that depend on the monomer species involved in the pairing interaction. Depending upon the relative values of the binding free energies involved, different morphologies of assemblies that include both components are formed, exhibiting paramagnetic-, ferromagnetic- or anti ferromagnetic-like order,i.e., random, blocky or alternating ordering of the two components in the assemblies. Analyzing the model for the case of ferromagnetic ordering, which is of most practical interest, we find that the transition from conditions of minimal assembly to those characterized by strong polymerization can be described by a critical concentration that depends on the concentration ratio of the two species. Interestingly, the distribution of monomers in the assemblies is different from that in the original distribution, i.e., the ratio of the concentrations of the two components put into the system. The monomers with a smaller binding free energy are more abundant in short assemblies and monomers with a larger binding affinity are more abundant in longer assemblies. Under certain conditions the two components congregate into separate supramolecular polymeric species and in that sense phase separate. We find strong deviations from the expected growth law for supramolecular polymers even for modest amounts of a second component, provided it is chemically sufficiently distinct from the main one.
description: Submitted to Macromolecules, 6 figures. arXiv admin note: substantial text overlap with arXiv:1111.1767
On the problems of detecting Fast Radio Bursts with the LPA LPI
Creators: name: Brylyakova, E. A.
name: Tyul'bashev, S. A.
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The paper presents the verification of previously published fast radio bursts (FRB) from the work of V.A. Fedorova and A.E. Rodin, detected in the monitoring data of the Large Phased Array (LPA) radio telescope using a search algorithm based on the convolution of data with a scattered pulse pattern. The same 6-channel data (channel width 415 kHz) were used for verification, in which FRBs were detected with dispersion measures of 247, 570 and 1767 pc/cm3. Additional verification of the published FRB was also carried out in 32-channel data (channel width 78 kHz). We have not been able to confirm any published FRB on the signal-to-noise ratios stated in the original paper. The main errors are caused by incorrect identification of the baseline and incorrect estimation of the standard deviations of noise.
description: published in Astronomy Reports, translated by Yandex translator with correction of scientific lexis, 7 pages, 3 figures, 1 table
Constraining the orbital history of the Magellanic Clouds: A new bound scenario suggested by the tidal origin of the Magellanic Stream
Creators: name: Diaz, Jonathan
name: Bekki, Kenji
Publisher: name: arXiv
Year: 2011
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Bound orbits have traditionally been assigned to the Large and Small Magellanic Clouds (LMC and SMC, respectively) in order to provide a formation scenario for the Magellanic Stream (MS) and its Leading Arm (LA), two prominent neutral hydrogen (HI) features connected to the LMC and SMC. However, Hubble Space Telescope (HST) measurements of the proper motions of the LMC and SMC have challenged the plausibility of bound orbits, causing the origin of the MS to re-emerge as a contested issue. We present a new tidal model in which structures resembling the bifurcated MS and elongated LA are able to form in a bound orbit consistent with the HST proper motions. The LMC and SMC have remained bound to each other only recently in our model despite being separately bound to the Milky Way for more than 5 Gyr. We find that the MS and LA are able to form as a consequence of LMC-dominated tidal stripping during the recent dynamical coupling of the LMC and SMC. Our orbital model depends on our assumption that the Milky Way has a constant circular velocity of V_cir=250 km/s up to 160 kpc, which implies a massive isothermal halo that is not completely rejected by observations.
description: 7 pages, 6 figures, 1 table, accepted by MNRAS. Supplementary animation will be available through MNRAS
THE NEW WAY TO THE GENE THERAPEUTIC CORRECTION OF THE PATHOGENETIC MECHANISMS OF CORONARY INSUFFICIENCY
Creators: name: Makeev, O.
name: Schuman, E.
name: Korotkov, A.
name: Kostyukova, S.
name: Satonkina, O.
Publisher: name: Sciences of Europe
Year: 2021
Subjects: angiogenesis
ischemic myocardium
HIF1a
HIF1b
VEGF165
VEGF225.

description: The problem of angiogenesis in the ischemic myocardium is the main item for the widespread prevalence of cardiovascular diseases. The mechanism is the age-dependent epigenetic blockade of the corresponding genes. In model experiments, it was shown that transfection of ischemic myocardium with plasmid vectors carrying the HIF1a, HIF1b, VEGF165, VEGF225 genes in a stoichiometric ratio of 1: 0.2: 0.5: 0.3, at a concentration of 400 μg / ml of physiological solution at a rate of 200 μg DNA per cm2 of ischemia zone and a step over an area of 210 mm, with the addition of an adjuvant 2-dimethylaminoethanol at a concentration of 2.5 mmol / L, restores full neoangiogenesis. It was shown for the first time that with the use of four genes, including the formation of a complete vasculature with myocardium
Il consiglio di cooperazione
Creators: name: Guglielmini, Sofia
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2017

description: Questo lavoro di Bachelor presenta la ricerca-azione da me effettuata sul consiglio di cooperazione e sulla relativa applicazione nella mia classe (terza elementare), da gennaio a oggi. Nello specifico ho valutato l’efficacia di questo spazio-tempo con riferimento alle interazioni affettive presenti nella classe e all’accettazione dell’ “altro”. Tramite un questionario sul benessere della classe, un’osservazione partecipante continua e dei test sociometrici e di percezione sociometrica, sono giunta alla conclusione che, relativamente alla mia classe, il consiglio di cooperazione, affiancato da regolari lavori di tipo collaborativo, possa essere uno strumento oltremodo efficace. Le relazioni affettive intercorrenti tra i miei bambini a inizio percorso hanno senz’altro vissuto un importante mutamento in positivo, con un aumento di scelte reciproche. Tale evento ha generato un comune miglioramento del clima di classe, difatti “il senso di essere un gruppo nasce quando i membri che lo costituiscono scelgono di stabilire interazioni personali e dirette e, soprattutto, si impegnano a mirare al benessere e all’autorealizzazione di ciascun componente” (Polito, 2000).
Doping on the kagome lattice: A variational Monte-Carlo study of the $t-J$ model
Creators: name: Guertler, Siegfried
name: Monien, Hartmut
Publisher: name: arXiv
Year: 2011
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We study doping on the Kagome lattice by exploring the $t-J$-model with variational Monte-Carlo. We use a number of Gutzwiller projected spin-liquid and valence bond-crystal states and compare their energies at several system-sizes. We find that introducing mobile holes drives the system away from the Spin-Liquid state proposed by Ran et al for the undoped system, towards a uniform state with zero-flux. On top of the uniform-state a VBC of the Hastings-type is formed for low doping. The results are compared to exact diagonalization on small clusters. This agrees well.
description: 5 pages, 7 figures
GIS ANALYSIS OF PHYSICAL ACCESSIBILITY TO FOOD MARKETS IN THARAKA REGION OF KENYA
Creators: name: KIBETU, Dickson Kinoti
name: HUHO, Julius Mburu
name: OUNA, Tom Odhiambo
name: KIBETU, Dickson Kinoti
name: HUHO, Julius Mburu
name: OUNA, Tom Odhiambo
Publisher: name: Unknown
Year: 2020
Subjects: subject: Agribusiness
subject: Agricultural and Food Policy
subject: Food Consumption/Nutrition/Food Safety
subject: Food Security and Poverty
subject: Marketing
subject: FOS: Economics and business
subject: Research and Development/Tech Change/Emerging Technologies
subject: geographic accessibility
subject: open air markets
subject: food security
subject: GIS

description: In semi-arid rural Kenya, most households travel long distances to access food markets. This has negative effects on food consumption and the use of market facilities. Over70 % of farmers in Tharaka Constituency lack access to formal markets often relying on contracted middlemen who buy at farm gate for traders in major urban centres. Studies on intra-variation in accessibility to market services remains scanty, yet market purchases account for most food consumed across urban and rural areas. Distance defines accessibility and performance of market facilities in most areas where food insecurity and malnutrition are common. This study used Geographic Information Systems (GIS) to measure physical accessibility to open air markets within semi-arid Tharaka, a constituency where vulnerability to acute food shortage is comparatively high. Normative, administrative and geospatial datasets were used in the analysis. Results showed that geographic accessibility to local market centres vary spatially across the villages. In terms of market accessibility, 40.4% of the total population live in areas with high inaccessibility risks while 36.1% are found in places with low inaccessibility risks and only 23.5% of the population exists in areas with moderate inaccessibility risks. This means a large proportion of deprived population live in villages within high to very high inaccessibility risk areas. This spatial inequity has implications on household food security and explains the chronic problems of hunger and malnutrition experienced in the area. Therefore, markets within high inaccessibility risk areas should be upgraded and infrastructure thereof improved to enable food mobility across these areas.
description: doi: 10.15414/raae.2020.23.02.36-44; https://roaae.org/issue/review-of-agricultural-and-applied-economics-raae-vol-23-no-2-2020-2/?article=gis-analysis-of-physical-accessibility-to-food-markets-in-tharaka-region-of-kenya
Role of Village Committee in Promoting Democracy: The Case Study of Khlong Kok Village, Moo 12, Bankuan Subdistrict, Lang Suan District, Chumphon Province
Creators: name: Napat Damnil
Publisher: name: Department of Political Science, Mahamakut Buddhist University
Year: 2023
Subjects: Village committee
Democracy
Chumphon Province

description: Journal of Political Science Mahamakut Buddhist University, 3, 2, 1-15
Reducing off-flavour in plant protein isolates by lactic acid fermentation
Creators: name: Shi, Yuan
Publisher: name: University of British Columbia
Year: 2020

description: Pea is a nutritious legume that can be used as an animal protein substitute. However, the unpleasant greeny aroma severely inhibits the application of pea-derived proteins as a food ingredient. This study aims at improving the aroma of pea protein isolates (PPIs) with an aim to employ these PPIs for plant-based dairy substitute production. Major objective of this study is to establish the applicability of lactic acid fermentation (LAF) in eliminating unpleasant aroma from PPIs while maintaining the functional properties and protein quality. We hypothesize that LAF treatment can reduce the undesirable aroma of pea protein isolates by virtue of desirable bacterial action on plant proteins. A solid-phase microextraction followed by gas chromatography-mass spectrometry (SPME-GC-MS) method was developed in this study to identify and quantify the volatile compound profile of plant-based protein. Total concentration of volatile compounds belonging to aldehyde, ketone and alcohol group in the pea, soy and brown rice protein is analyzed and compared. Different LAF treatments are performed with Lactobacillus plantarum, Lactobacillus casei and mixed strains of probiotics. The protein quality of treated and untreated protein sample is analyzed by the Bradford protein assay and sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE). Evolution of functional properties including emulsifying properties, foaming properties, water holding and oil binding capacities of samples with different times of lactic acid fermentation treatments are also analyzed. Based on the experimental results, the water-soluble protein content decreased with the increase of fermentation time, with protein configuration majorly altered beyond 15-hour of fermentation. Thus, a 10-hour L. plantarum fermentation was found optimal in eliminating off-flavour while maintaining protein quality and functional properties. For the optimal treatment, around 42% aldehyde and 64% ketone content were removed, and a small amount of alcohol was produced. This change of the aroma compound profile is considered desirable for dairy substitute production. Results from a descriptive analysis sensory test showed that LAF treatment successfully decreased the overall aroma and flavour intensity in PPIs. The results of this study could be used by the Canadian Food Industry for pre-treating pea protein isolates, before using them as an ingredient in plant-based dairy substitutes.
On the Implications of Late Internal Dissipation for Shallow-Decay Afterglow Emission and Associated High-Energy Gamma-Ray Signals
Creators: name: Murase, Kohta
name: Toma, Kenji
name: Yamazaki, Ryo
name: Meszaros, Peter
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The origin of the shallow-decay emission during early X-ray afterglows has been an open issue since the launch of the Swift satellite. One of the appealing models is the late internal dissipation model, where X-ray emission during the shallow-decay phase is attributed to internal dissipation, analogous to the prompt gamma-ray emission. We discuss possible scenarios of the late prompt emission, such as late internal shocks, magnetic reconnection, and photospheric dissipation. We also consider the consequences of late dissipation and a two-component (early and late) jet model for the high-energy (GeV-TeV) emission. We study not only synchrotron self-Compton (SSC) emission from the early and late jets but also external inverse-Compton (EIC) emission, which is naturally predicted in the late dissipation model. For the latter, we perform numerical calculations taking into account the equal-arrival-time surface of EIC photons and show that the EIC component typically has a peak at ~1-100 GeV which may dominate over the SSC components. We demonstrate that very high energy gamma rays from both these components are detectable for nearby and/or energetic gamma-ray bursts, with current and future Cherenkov detectors such as MAGIC, VERITAS, CTA and HAWC, and possibly Fermi. Although the expected event rate would not be large, detections should be useful as a test of the model. Multi-wavelength observations using both the ground-based telescopes and the Swift and/or Fermi satellites are also important to constrain the models.
description: 16 pages, 16 figures, minor revisions; published in ApJ 04/19/2011; accepted 03/03/2011
The observation of Extensive Air Showers from an Earth-Orbiting Satellite
Creators: name: Pallavicini, M.
name: Pesce, R.
name: Petrolini, A.
name: Thea, A.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: In this paper we review the main issues that are relevant for the detection of Extensive Air Showers (EAS) from space. EAS are produced by the interaction of Ultra-High Energy Cosmic Particles (UHECP) with the atmosphere and can be observed from an orbiting telescope by detecting air fluorescence UV light. We define the requirements and provide the main formulas and plots needed to design and optimize a suitable telescope. We finally estimate its expected performances in ideal conditions.
description: 24 pages, 10 figures; submitted to Astroparticle Physics 27 pages, 14 figures; major revision; added new figures and sections; typos fixed. arXiv admin note: substantial text overlap with arXiv:0810.5711
A characterization of the electromagnetic stress-energy tensor
Creators: name: Navarro, J.
name: Sancho, J. B.
Publisher: name: arXiv
Year: 2011
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In a previous paper, we pointed out how a dimensional analysis of the stress-energy tensor of the gravitational field allows to derive the field equation of General Relativity. In this note, we comment an analogous reasoning in presence of a 2-form, that allows to characterize the so called electromagnetic stress-energy tensor.
description: 4 pages
Additional file 1: of Physiological, hematological and biochemical factors associated with high-altitude headache in young Chinese males following acute exposure at 3700Â m
Creators: name: Wang, Kun
name: Zhang, Menghan
name: Li, Yi
name: Pu, Weilin
name: Ma, Yanyun
name: Wang, Yi
name: Liu, Xiaoyu
name: Kang, Longli
name: Wang, Xiaofeng
name: Wang, Jiucun
name: Qiao, Bin
name: Jin, Li
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology
subject: Computational Biology

description: The distribution and QQ-norm plot of SpO2 at 50 m and 3700 m. (DOCX 168 kb)
Linear Stability Analysis of Symmetric Periodic Simultaneous Binary Collision Orbits in the Planar Pairwise Symmetric Four-Body Problem
Creators: name: Bakker, Lennard F.
name: Mancuso, Scott C.
name: Simmons, Skyler C.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: 70F10, 70H12, 70H14, 70F16, 70H33

description: We apply the symmetry reduction method of Roberts to numerically analyze the linear stability of a one-parameter family of symmetric periodic orbits with regularizable simultaneous binary collisions in the planar pairwise symmetric four-body problem with a mass $m\in(0,1]$ as the parameter. This reduces the linear stability analysis to the computation of two eigenvalues of a $3\times 3$ matrix for each $m\in(0,1]$ obtained from numerical integration of the linearized regularized equations along only the first one-eighth of each regularized periodic orbit. The results are that the family of symmetric periodic orbits with regularizable simultaneous binary collisions changes its linear stability type several times as $m$ varies over $(0,1]$, with linear instability for $m$ close or equal to 0.01, and linear stability for $m$ close or equal to 1.
description: 13 pages, 1 figure
Additional file 2: of Physiological, hematological and biochemical factors associated with high-altitude headache in young Chinese males following acute exposure at 3700Â m
Creators: name: Wang, Kun
name: Zhang, Menghan
name: Li, Yi
name: Pu, Weilin
name: Ma, Yanyun
name: Wang, Yi
name: Liu, Xiaoyu
name: Kang, Longli
name: Wang, Xiaofeng
name: Wang, Jiucun
name: Qiao, Bin
name: Jin, Li
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Plant Biology
subject: Computational Biology

description: The incidence of mild, moderate and severe headaches after ascent to 3700 m altitude. (DOCX 16 kb)
Isomorphism and embedding of Borel systems on full sets
Creators: name: Hochman, Michael
Publisher: name: arXiv
Year: 2010
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 37A35

description: A Borel system consists of a measurable automorphism of a standard Borel space. We consider Borel embeddings and isomorphisms between such systems modulo null sets, i.e. sets which have measure zero for every invariant probability measure. For every t>0 we show that in this category there exists a unique free Borel system (Y,S) which is strictly t-universal in the sense that all invariant measures on Y have entropy
description: 17 pages, v2: correction to bibliography
Linguistic trade-offs among syntax and semantics in the narrative language of typically-developing children and children with specific language impairment
Creators: name: Garcia, Rebecca Diane
Publisher: name: The University of Texas at Austin
Year: 2005
Subjects: Specific language impairment
Linguistic trade-off

description: The current study examined the presence of linguistic trade-offs among the domains of syntax and semantics in the narratives of children with specific language impairment (SLI) in comparison to typically-developing children. Measures of linguistic trade-offs were obtained using a Relative Strength of Form (RSF) index, which incorporated scores of ten items from the Late for School and Aliens story telling tasks of the TNL. SLI and control groups were divided into three categories defined by low grammar and high semantic performance, relatively equal grammar and semantic performance, and higher grammar and lower semantic performance. Categorization was based on RSF index scores, and specified the degree of linguistic discrepancy within each child. The results indicated that language-impaired children were more likely than nonimpaired children to exhibit linguistic trade-offs, pointing to group differences in generalized processing capacities
Entropy, Contact Interaction with Horizon and Dark Energy
Creators: name: Zhitnitsky, Ariel R.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present some arguments suggesting that the mismatch between Bekenstein- Hawking entropy and the entropy of entanglement for vector fields is due to the same gauge configurations which saturate the contact term in topological susceptibility in QCD. In both cases the extra term with a "wrong sign" is due to distinct topological sectors in gauge theories. This extra term has non-dispersive nature, can not be restored from conventional spectral function through dispersion relations, and can not be associated with any physical propagating degrees of freedom. We make few comments on some profound consequences of our findings. In particular, we speculate that the source of the observed dark energy may also be related to the same type of gauge configurations which are responsible for the mismatch between black hole entropy and the entropy of entanglement in the presence of causal horizon.
description: final version to appear in Phys. Rev. D (2011)
Risdiplam: A Review in Spinal Muscular Atrophy
Creators: name: Paik, Julia
Publisher: name: Adis Journals
Year: 2022
Subjects: subject: Medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine

description: Declarations Funding The preparation of this review was not supported by any external funding. Authorship and Conflict of interest Julia Paik is a salaried employee of Adis International Ltd/Springer Nature, and declares no relevant conflicts of interest. All authors contributed to the review and are responsible for the article content. Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability not applicable Additional information about this Adis Drug Review can be found here Abstract Risdiplam (Evrysdi®) is the first oral drug developed to treat spinal muscular atrophy (SMA) and is approved in multiple countries worldwide. It is approved for the treatment of SMA in patients aged ≥ 2 months in the USA and the EU, with this approval further specified in the EU for the treatment of 5q-autosomal recessive SMA with a clinical diagnosis of SMA types 1, 2, or 3 or with one to four survival motor neuron 2 (SMN2) copies. As an SMN2 pre-mRNA splicing modifier, risdiplam increases the production of full-length SMN protein, the lack of which drives the pathophysiology of SMA. In phase 2/3 clinical trials, risdiplam significantly improved motor function in infants with SMA type 1 and in patients aged 2–25 years with SMA types 2 or 3. These motor improvements were maintained with up to 2 years of treatment with risdiplam. Risdiplam had a generally acceptable tolerability profile in these trials. As an oral drug, risdiplam provides a convenient and useful treatment option across a broad range of patient ages and subtypes of SMA. © Springer Nature Switzerland AG 2022
title: ÐÐ°Ð´Ð°ÑÐ° ÑÐºÑÐ¿ÑÐµÑÑ-Ð¾ÑÐµÐ½ÐºÐ¸ ÐºÐ¾ÑÑÐµÐºÑÐ½Ð¾ÑÑÐ¸ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÑÑÐµÑÐ¸Ð½Ñ Ð³ÑÐ¿ Ð½Ð° Ð¿ÑÐ¸Ð¼ÐµÑÐµ Ð¿Ð¾ÑÑÐ°Ð½Ð¾Ð²ÐºÐ¸ Planar3D
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: The task of express evaluation of the correctness of hydraulic fracturing modeling by the example of Planar3D statement
Creators: name: ÐÐ°ÑÑÑÐºÐ¾Ð², Ð¡ÐµÐ²Ð°ÑÑÑÑÐ½
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: Ð³Ð¸Ð´ÑÐ¾ÑÐ°Ð·ÑÑÐ² Ð¿Ð»Ð°ÑÑÐ°
Ð¼ÐµÑÐ¾Ð´Ð¸ÐºÐ° ÑÐµÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ
Ð¼Ð¾Ð´ÑÐ»Ñ Planar3D
Ð¿ÑÐµÐ´ÐµÐ»ÑÐ½ÑÐµ Ð¿ÐµÑÐµÑ Ð¾Ð´Ñ
ÑÑÐµÑÐºÐ¸
hydraulic fracturing
testing method
module Planar3D
limit transitions
leakoff

description: Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð¿ÑÐ¾Ð²ÐµÑÐµÐ½Ð° ÐºÐ¾ÑÑÐµÐºÑÐ½Ð¾ÑÑÑ ÑÐµÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¾ÑÐ½Ð¾Ð²Ð½ÑÑ Ð´Ð¾Ð¿ÑÑÐµÐ½Ð¸Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸ Planar3D Ð² ÑÐ¸Ð¼ÑÐ»ÑÑÐ¾ÑÐµ Ð³Ð¸Ð´ÑÐ¾ÑÐ°Ð·ÑÑÐ²Ð° Ð¿Ð»Ð°ÑÑÐ° (ÐÐ Ð) Ð² ÑÑÐ»Ð¾Ð²Ð¸ÑÑ ÑÑÐµÑÑÐ»Ð¾Ð¹Ð½Ð¾Ð¹ ÑÐ¸Ð¼Ð¼ÐµÑÑÐ¸ÑÐ½Ð¾Ð¹ ÑÑÐµÐ´Ñ Ñ Ð¿Ð¾ÑÑÐ¾ÑÐ½Ð½Ð¾Ð¹ Ð·Ð°ÐºÐ°ÑÐºÐ¾Ð¹ Ð½ÑÑÑÐ¾Ð½Ð¾Ð²ÑÐºÐ¾Ð¹ Ð¶Ð¸Ð´ÐºÐ¾ÑÑÐ¸. ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½Ñ ÑÐµÑÑÑ Ð½Ð° Ð¿Ð¾Ð³ÑÐµÑÐ½Ð¾ÑÑÑ ÑÐ¸Ð¼ÑÐ»ÑÑÐ¾ÑÐ° ÐÐ Ð, Ð½Ð° Ð¿ÑÐµÐ´ÐµÐ»ÑÐ½ÑÐµ Ð¿ÐµÑÐµÑÐ¾Ð´Ñ Ð¸ Ð½Ð° ÑÑÐµÑÐºÐ¸ Ð¶Ð¸Ð´ÐºÐ¾ÑÑÐ¸.
description: In this paper, the correctness of the implementation of the basic assumptions of the Planar3D model in the hydraulic fracturing simulator in the formulation of a three-layer symmetric reservoir with constant injection of Newtonian fluid is verified. Tests were conducted for the error of the hydraulic fracturing simulator, for the limiting transitions, and for leakoff.
IMPROVEMENT OF ORGANIZATION OF INDEPENDENT WORK OF STUDENTS
Creators: name: Pavlovych, L.
name: Kamyshna, I.
name: Bakaliuk, T.
Publisher: name: Sciences of Europe
Year: 2021
Subjects: independent work of students

description: Objective. The article is sanctified to the problem of perfection of organization of independent work of students, determination of ways of the methodical providing of the marked process.
Edge Charge Asymmetry in Top Pair Production at the LHC
Creators: name: Xiao, Bo
name: Wang, You-Kai
name: Zhou, Zhong-Qiu
name: Zhu, Shou-hua
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: In this brief report, we propose a new definition of charge asymmetry in top pair production at the LHC, namely the edge charge asymmetry (ECA). ECA utilizes the information of drifting direction only for single top (or anti-top) with hadronically decay. Therefore ECA can be free from the uncertainty arising from the missing neutrino in the $t\bar{t}$ event reconstruction. Moreover rapidity $Y$ of top (or anti-top) is required to be greater than a critical value $Y_{\rm C}$ in order to suppress the symmetric $t\bar{t}$ events mainly due to the gluon-gluon fusion process. In this paper ECA is calculated up to next-to-leading order QCD in the standard model and the choice of the optimal $Y_{\rm C}$ is investigated.
description: 10 pages, 6 figures
title: ÐÑÐ»Ð¸ÑÐ¸ÑÐµÐ»ÑÐ½ÑÐµ Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸ ÑÑÐ°Ð½ÑÑÐ·ÑÐºÐ¾Ð³Ð¾ ÑÐ·ÑÐºÐ° Ð² ÐÐ°Ð½Ð°Ð´Ðµ (Ð½Ð° Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ðµ ÑÐµÑÐ¸Ð°Ð»Ð° Les Bougon: câest aussi Ã§a la vie)
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: The distinctive features of the Canadian French on the basis of the series "Les Bougon â câest aussi Ã§a la vie!"
Creators: name: ÐÐ¾Ð½Ð´ÑÐ°ÑÐµÐ²Ð°, ÐÐ»ÐµÐºÑÐ°Ð½Ð´ÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2023
Subjects: ÑÑÐ°Ð½ÑÑÐ·ÑÐºÐ¸Ð¹ ÑÐ·ÑÐº
ÐÐ°Ð½Ð°Ð´Ð°
ÑÑÐ°Ð½ÐºÐ¾-ÐºÐ°Ð½Ð°Ð´ÑÐºÐ¸Ð¹ ÑÐ·ÑÐº
french language
Canada
canadian french

description: Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð½Ð° Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ðµ ÑÐµÑÐ¸Ð°Ð»Ð° âLes Bougon â cest aussi Ã§a la vie!â ÑÐ°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ñ Ð¾ÑÐ»Ð¸ÑÐ¸ÑÐµÐ»ÑÐ½ÑÐµ ÑÐµÑÑÑ ÐºÐ°Ð½Ð°Ð´ÑÐºÐ¾Ð³Ð¾ Ð²Ð°ÑÐ¸Ð°Ð½ÑÐ° ÑÑÐ°Ð½ÑÑÐ·ÑÐºÐ¾Ð³Ð¾ ÑÐ·ÑÐºÐ° Ð² ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ð¸ ÑÐ¾ ÑÑÐ°Ð½Ð´Ð°ÑÑÐ½ÑÐ¼ Ð²Ð°ÑÐ¸Ð°Ð½ÑÐ¾Ð¼ ÑÑÐ°Ð½ÑÑÐ·ÑÐºÐ¾Ð³Ð¾ ÑÐ·ÑÐºÐ°. ÐÑÐ¾Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð° Ð¸ÑÑÐ¾ÑÐ¸Ñ ÑÐ°ÑÐ¿ÑÐ¾ÑÑÑÐ°Ð½ÐµÐ½Ð¸Ñ ÑÑÐ°Ð½ÑÑÐ·ÑÐºÐ¾Ð³Ð¾ ÑÐ·ÑÐºÐ° Ð½Ð° ÑÐµÑÑÐ¸ÑÐ¾ÑÐ¸Ð¸ ÐÐ°Ð½Ð°Ð´Ñ, Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½ ÑÐ¾Ð²ÑÐµÐ¼ÐµÐ½Ð½ÑÐ¹ ÑÑÐ°ÑÑÑ ÑÑÐ°Ð½ÑÑÐ·ÑÐºÐ¾Ð³Ð¾ ÑÐ·ÑÐºÐ° Ð² ÐÐ°Ð½Ð°Ð´Ðµ. ÐÐ¿Ð¸ÑÐ°ÑÑÑ Ð½Ð° ÑÐ°Ð±Ð¾ÑÑ ÑÑÐµÐ½ÑÑ-Ð»Ð¸Ð½Ð³Ð²Ð¸ÑÑÐ¾Ð², Ð±ÑÐ»Ð¸ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ñ Ð¾ÑÐ½Ð¾Ð²Ð½ÑÐµ Ð»ÐµÐºÑÐ¸ÑÐµÑÐºÐ¸Ðµ, ÑÐ¾Ð½ÐµÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð¸ Ð³ÑÐ°Ð¼Ð¼Ð°ÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸, Ð¿ÑÐ¸Ð¼ÐµÑÑ ÐºÐ¾ÑÐ¾ÑÑÑ Ð¿ÑÐ¾Ð´ÐµÐ¼Ð¾Ð½ÑÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ñ Ð² Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÑÐµÐ¼Ð¾Ð¼ ÑÐ¸ÑÐºÐ¾Ð¼Ðµ âLes Bougon â câest aussi Ã§a la vie!â. ÐÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ°Ñ Ð·Ð½Ð°ÑÐ¸Ð¼Ð¾ÑÑÑ ÑÐ°Ð±Ð¾ÑÑ ÑÐ¾ÑÑÐ¾Ð¸Ñ Ð² ÑÐ¾Ð¼, ÑÑÐ¾ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¼Ð¾Ð³ÑÑ Ð±ÑÑÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ñ Ð² ÐºÐ°ÑÐµÑÑÐ²Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°ÑÐµÐ»ÑÑÐºÐ¾Ð¹ Ð±Ð°Ð·Ñ, Ð°Ð½Ð°Ð»Ð¸ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð¸ Ð¿ÑÐ¾ÐµÐºÑÐ½Ð¾Ð¹ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ Ð»Ð¸Ð½Ð³Ð²Ð¸ÑÑÐ¾Ð², ÑÐ°ÑÑÐ¼Ð°ÑÑÐ¸Ð²Ð°ÑÑÐ¸Ñ ÑÐµÐ¼Ñ ÐºÐ°Ð½Ð°Ð´ÑÐºÐ¾Ð³Ð¾ Ð²Ð°ÑÐ¸Ð°Ð½ÑÐ° ÑÑÐ°Ð½ÑÑÐ·ÑÐºÐ¾Ð³Ð¾ ÑÐ·ÑÐºÐ°.
description: In this work on the material of the series "Les Bougon â câest aussi Ã§a la vie!" distinctive features of the Canadian variant of the French language in comparison with the standard variant of the French language are considered. The history of the distribution of the French language in Canada has been analyzed, the current status of the French language in Canada has been determined. Basing on the work of linguists, the main lexical, phonetic and grammatical features, examples of which are demonstrated in the analyzed sitcom "Les Bougon â câest aussi Ã§a la vie!". The practical importance of the research is that the results of the study can be used as a basis for the research, analysis and design for linguists dealing with the Canadian French.
Designing Bugs or Doing Another Project: Effects on Secondary Students' Self-Beliefs in Computer Science
Creators: name: Morales-Navarro, Luis
name: Fields, Deborah A.
name: Giang, Michael
name: Kafai, Yasmin B
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences
subject: K.3.2

description: Debugging, finding and fixing bugs in code, is a heterogeneous process that shapes novice learners' self-beliefs and motivation in computing. Our Debugging by Design intervention (DbD) provocatively puts students in control over bugs by having them collaborate on designing creative buggy projects during an electronic textiles unit in an introductory computing course. We implemented DbD virtually in eight classrooms with two teachers in public schools with historically marginalized populations, using a quasi-experimental design. Data from this study included post-activity results from a validated survey instrument (N=144). For all students, project completion correlated with increased computer science creative expression and e-textiles coding self-efficacy. In the comparison classes, project completion correlated with reduced programming anxiety, problem-solving competency beliefs, and programming self-concept. In DbD classes, project completion is uniquely correlated with increased fascination with design and programming growth mindset. In the discussion, we consider the relative benefits of DbD versus other open-ended projects.
Un ciclo attorno all'acquario: lezioni tenute alla scuola pratica di Locarno da Giuseppe Mondada. Minerva : rivista della scuola magistrale - Anno III No. 9-10, Locarno, settembre-ottobre 1938
Creators: name: Mondada, Giuseppe
Publisher: name: Locarno
Year: 1938
Subjects: Agriculture
Food education
Civics
Technical and manual education
Italian
Scientific subjects (Biology, Chemistry, Physics, Geology, Sciences)

description: Volume monotematico di Giuseppe Mondada.
L'effet de la stratégie de remue-méninges sur les attitudes des élèves à l'égard du cours d'éducation physique et sportive en sports collectifs au secondaire
Creators: name: BEDDA, Messaoud
name: BEKAI, Ismail
name: AIDI, Mourad
Publisher: name: Zenodo
Year: 2024
Subjects: Brainstorming, Attitudes Towards Séance , Physical Sporting Activity, Team Sports Secondary Cycle

description: The study aimed to identify the effect of the brainstorming strategy on students’ emotional attitudes towards the physical education and sports class in teams sports in the secondary stage. For this purpose, we used the experimental approach on a sample consisting of 58 students, which were randomly selected. To collect data, we used the attitude scale. After collecting the information and processing it statistically, it was concluded that the brainstorming strategy had an impact on students’ emotional attitudes toward the physical education andsports class in team sports. On this basis, the study recommended giving importance to modern teachingstrategies, especially in the field of physical activity.
Superconductivity in Mo$_4$Ga$_{20}$As with Endohedral Gallium Clusters
Creators: name: Ruan, Bin-Bin
name: Chen, Le-Wei
name: Shi, Yun-Qing
name: Yi, Jun-Kun
name: Yang, Qing-Song
name: Zhou, Meng-Hu
name: Ma, Ming-Wei
name: Chen, Gen-Fu
name: Ren, Zhi-An
Publisher: name: arXiv
Year: 2023
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We report the discovery and detailed investigation of superconductivity in Mo$_4$Ga$_{20}$As. Mo$_4$Ga$_{20}$As crystallizes in the space group of $I4/m$ (No. 87), with lattice parameters $a$ = 12.86352 Åand $c$ = 5.30031 Å. The resistivity, magnetization, and specific heat data reveal Mo$_4$Ga$_{20}$As to be a type-II superconductor with $T_c$ = 5.6 K. The upper and lower critical fields are estimated to be 2.78 T and 22.0 mT, respectively. In addition, electron-phonon coupling in Mo$_4$Ga$_{20}$As is possibly stronger than the BCS weak-coupling limit. First-principles calculations suggest the Fermi level being dominated by the Mo-4$d$ and Ga-4$p$ orbitals.
THE NATURE OF JUDICIAL DECISIONS IN THE CONDITIONS OF THE DIGITAL TRANSFORMATION OF THE JUDICIAL POWER OF UZBEKISTAN
Creators: name: Ruzinazarov Sh.
name: Ibratova, F.
name: Kalkanova Zh.
Publisher: name: Sciences of Europe
Year: 2021
Subjects: judicial act
electronic court proceedings
electronic access
electronic format
information system.

description: The article discusses the issues of creating conditions for the parties to receive court decisions online, strengthening measures to ensure information and cybersecurity of information systems. It is concluded that special legislative regulation of judicial acts will provide an opportunity for effective legal protection of the rights and interests of subjects of digital civil circulation.
I punti di riferimento nella città: geografia in classe o sul territorio?
Creators: name: Logori, Laura
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2015

description: La seguente ricerca aveva lo scopo di confrontare due metodologie dell’insegnamento della geografia. Gli allievi dovevano aiutare un simpatico turista di nome Fredrich ad arrivare al Castelgrande partendo dalle scuola elementari di Bellinzona Nord. I bambini hanno individuato dei punti di riferimento utili al turista e creato un percorso che gli permettesse di arrivare al castello. L’indagine qui presentata aveva l’obiettivo di scoprire se l’uscita sul territorio potesse migliorare l’orientamento spaziale, rispetto allo svolgere lezioni di geografia rimanendo in classe. Per verificare quale metodologia di lavoro sviluppasse meglio questo aspetto, i bambini a gruppi hanno collocato su una mappa i punti di riferimento. Inizialmente gli allievi si sono basati sulle loro esperienze per riuscire a disporre quest’ultimi nella carta geografica, mentre la seconda collocazione è avvenuta dopo l’uscita sul territorio. Dall’analisi dei dati emerge che l’uscita, grazie anche alla visione della città dal Castelgrande, ha consentito un miglioramento, non solo per quanto concerne l’orientamento spaziale, ma anche nella lettura della carta geografica. Gli allievi hanno dimostrato anche una maggiore precisione nel disporre i punti di riferimento. Relatore: Reto Torti.
Making Sense of Machine Learning: Integrating Youth's Conceptual, Creative, and Critical Understandings of AI
Creators: name: Morales-Navarro, Luis
name: Kafai, Yasmin B.
name: Castro, Francisco
name: Payne, William
name: DesPortes, Kayla
name: DiPaola, Daniella
name: Williams, Randi
name: Ali, Safinah
name: Breazeal, Cynthia
name: Lee, Clifford
name: Soep, Elisabeth
name: Long, Duri
name: Magerko, Brian
name: Solyst, Jaemarie
name: Ogan, Amy
name: Tatar, Cansu
name: Jiang, Shiyan
name: Chao, Jie
name: Rosé, Carolyn P.
name: Vakil, Sepehr
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences
subject: K.3.2; H.5.3

description: Understanding how youth make sense of machine learning and how learning about machine learning can be supported in and out of school is more relevant than ever before as young people interact with machine learning powered applications everyday; while connecting with friends, listening to music, playing games, or attending school. In this symposium, we present different perspectives on understanding how learners make sense of machine learning in their everyday lives, how sensemaking of machine learning can be supported in and out of school through the construction of applications, and how youth critically evaluate machine learning powered systems. We discuss how sensemaking of machine learning applications involves the development and integration of conceptual, creative, and critical understandings that are increasingly important to prepare youth to participate in the world.
Additional file 1 of Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) moonlights as an adhesin in Mycoplasma hyorhinis adhesion to epithelial cells as well as a plasminogen receptor mediating extracellular matrix degradation
Creators: name: Wang, Jia
name: Li, Yao
name: Pan, Longji
name: Li, Jun
name: Yu, Yanfei
name: Liu, Beibei
name: Zubair, Muhammad
name: Wei, Yanna
name: Pillay, Bala
name: Olaniran, Ademola Olufolahan
name: Chiliza, Thamsanqa E.
name: Shao, Guoqing
name: Feng, Zhixin
name: Xiong, Qiyan
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Neuroscience
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Assessment of the reactivity and specificity of the prepared polyclonal antibody against rGAPDH. A The whole cell protein of E. coli and purified rGAPDH protein were subjected to 12% SDS-PAGE and transferred to a polyvinylidene fluoride (PVDF) membrane. After blocking with 5% skim milk in TBST buffer, the membrane was incubated with the anti-GAPDH sera (1:5000), followed by horseradish peroxidase (HRP)-conjugated goat anti-rabbit IgG (1:10 000 dilution). Finally, filters were developed with Electro-Chemi-Luminescence (ECL) substrate using a ChemiDoc XRS + system (Bio-Rad, USA). M, protein molecular weight marker, lane 1, whole cell lysate of E. coli BL21 carrying empty vector pET-28a( +) before induction, lane 2 and 3, whole cell lysate of E. coli BL21 carrying recombinant vector pET-28a-gapdh before and after induction by IPTG overnight; lane 4, purified rGAPDH through Ni-chelating affinity chromatography. B, C The hybridization to the whole cell lysate of M. hyorhinis was furtherly conducted to assess the specificity of the polyclonal antibody against rGAPDH (B). The sera obtained before immunization was used as negative control (C). M, protein molecular weight marker; lane 1, whole cell lysate of M. hyorhinis, lane 2, purified rGAPDH.
The cosmological constant and the black hole equation of state
Creators: name: Dolan, Brian P.
Publisher: name: arXiv
Year: 2010
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The thermodynamics of black holes in various dimensions are described in the presence of a negative cosmological constant which is treated as a thermodynamic variable, interpreted as a pressure in the equation of state. The black hole mass is then identified with the enthalpy, rather than the internal energy, and heat capacities are calculated at constant pressure not at constant volume. The Euclidean action is associated with a bridge equation for the Gibbs free energy and not the Helmholtz free energy. Quantum corrections to the enthalpy and the equation of state of the BTZ black hole are studied.
description: 20 pages, 4 figures: some typos corrected in v5
Heavy Ion Initial Conditions and Correlations Between Higher Moments in the Spatial Anisotropy
Creators: name: Nagle, James L.
name: McCumber, Michael P.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Fluctuations in the initial conditions for relativistic heavy ion collisions are proving to be crucial to understanding final state flow and jet quenching observables. The initial geometry has been parametrized in terms of moments in the spatial anisotropy (i.e. $ε_2, ε_3, ε_4, ε_5...$), and it has been stated in multiple published articles that the vector directions of odd moments are uncorrelated with the even moments and the reaction place angle. In this article, we demonstrate that this is incorrect and that a substantial correlation exists between the even and odd moments in peripheral Au+Au collisions. These correlations persist for all centralities, though at a very small level for the 0-55% most central collisions.
description: 4 pages, 6 figures