cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Use of withdrawal management services among people who use illicit drugs in Vancouver, Canada
Creators: name: Vipler, Sharon
name: Hayashi, Kanna
name: Milloy, M-J
name: Wood, Evan
name: Nosova, Ekaterina
name: Kerr, Thomas
name: Ti, Lianping
Publisher: name: BioMed Central
Year: 2018

description: Background: For many individuals with substance use disorders, the entry point for addiction treatment can be through withdrawal management (e.g. detoxification) services. However, little is known about the factors that predict withdrawal management service use among people who use illicit drugs (PWUD). Using data derived from two prospective cohorts of PWUD, we conducted a longitudinal data analysis of factors associated with use of withdrawal management services. Methods: Individuals participating in two cohorts of PWUD were prospectively followed between December 2005 and May 2016 in Vancouver, Canada. Bivariate and multivariate generalized estimating equations were used to examine factors associated with use of withdrawal management services. Results: Out of a total of 2001 participants, 339 (16.9%) individuals reported having been to a withdrawal management centre in the previous 6 months at some point during the study period. In multivariate analyses, male sex (adjusted odds ratio [AOR]: 1.62, 95% Confidence Interval [CI]: 1.17–2.24), homelessness (AOR: 1.86, 95% CI: 1.45–2.38), binge use of any substance (AOR: 1.34, 95% CI: 1.08–1.67), having attended a supervised injection facility (AOR: 1.66, 95% CI: 1.3–2.11), and having accessed other addiction medicine treatment or supports (other than withdrawal management services or opioid agonist therapy; AOR: 3.34, 95% CI: 2.64–4.22) were positively associated with having accessed withdrawal management services, whereas older age (AOR: 0.81, 95% CI: 0.7–0.94) was negatively associated with the outcome. Conclusions: This study identified specific factors associated with accessing withdrawal management services. Current evidence suggests a need to re-examine the provision of withdrawal management services. Consideration needs to be given to redesigning access to care and bridging to evidence-based addiction treatment, particularly for highly vulnerable subpopulations, identified in this study as females and older people.
Optimal Recovery of Potentials or Weights for Sturm-Liouville Problems with One Given Eigenvalue
Creators: name: Guo, Hongjie
Publisher: name: Swinburne
Year: 2024

description: Driven by the application in many fields, the extremal problems in Sturm-Liouville theory and inverse spectral problems have been hot issues. In the study of classical inverse spectral problems, it is generally necessary to know two sets of full spectral information to uniquely determine the potential functions. In fact, one can only detect a finite number of eigenvalues. This thesis focuses on the quantitative expression of infimum of integral modulus for potentials or weights of Sturm-Liouville problems and the attainable function when one eigenvalue is given, so as to realize the optimal recovery of potentials (weights).
Caspase-2 kills cells with extra centrosomes
Creators: name: Rizzotto, Dario
name: Vigorito, Vincenza
name: Villunger, Andreas
name: Fava, Luca
Publisher: name: Zenodo
Year: 2024

description: Centrosomes are membrane-less organelles that orchestrate a wide array of biological functions by acting as microtubule organizing centers. Here, we report that caspase-2-driven apoptosis is elicited in blood cells failing cytokinesis and that extra centrosomes are necessary to trigger this cell death. Activation of caspase-2 depends on the PIDDosome multi-protein complex and priming of PIDD1 at extra centrosomes is necessary for this pathway. Accordingly, loss of its centrosomal adapter, ANKRD26, allows for cell survival and unrestricted polyploidization in response to cytokinesis failure. Mechanistically, cell death is initiated upstream of mitochondria via caspase-2-mediated processing of the BCL2 family protein BID, driving BAX/BAK-dependent mitochondrial outer membrane permeabilization (MOMP). Remarkably, BID-deficient cells enforce apoptosis by engaging p53-dependent pro-apoptotic transcriptional responses initiated by caspase-2. Consistently, BID and MDM2 act as shared caspase-2 substrates, with BID being kinetically favored. Our findings document that the centrosome limits its own unscheduled duplication by the induction of PIDDosome-driven mitochondrial apoptosis to avoid potentially pathogenic polyploidization events.
“Only Fake Words” : Revisiting Catharine MacKinnon in the Age of Deepfake Pornography
Creators: name: Yong, Tina
Publisher: name: The University of British Columbia
Year: 2025

description: Over 95% of deepfakes contain non-consensual pornographic depictions of women. In the United States, First Amendment jurisprudence has lent credence to the emerging legal argument that deepfakes are immune from prohibition, on the grounds that they qualify as protected speech. In this paper, I revive Catharine MacKinnon’s argument in Only Words (1993) — that pornography should not be protected as speech because it constitutes gender inequality — to demonstrate why her work holds renewed salience in the deepfake age. I advance three distinct claims: firstly, conventional pornography and deepfakes are contiguous in their shared endorsement of sexual coercion. Secondly, deepfake pornography falsely constructs and silences women, which warrants its formal designation as discrimination rather than as constitutionally protected expression. Thirdly, drawing upon G.W.F. Hegel’s master-slave dialectic, I illustrate how fully synthetic pornography could constrain women’s sexual freedom in ways unforeseen by MacKinnon’s work, in part due to her myopic focus on the material harm of pornographic production and comparative inattention to how porn structures one’s sense of “self” and “other.” Taken together, I aim to answer the following question: What did MacKinnon get right about pornography, and how can we extend her account to more accurately diagnose novel dangers in the dawning age of artifice?
Immune responses upon Campylobacter jejuni infection of secondary abiotic mice lacking nucleotide-oligomerization-domain-2
Creators: name: Bereswill, Stefan
name: Grundmann, Ursula
name: Alutis, Marie E.
name: Fischer, Andre
name: Kuehl, Anja A.
name: Heimesaat, Markus M.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Campylobacter jejuni
subject: Nucleotide-oligomerization-domain-2 (Nod2)
subject: Secondary abiotic (gnotobiotic) mice
subject: Bacterial colonization properties
subject: Pro-inflammatory cytokines
subject: Adaptive immune cells
subject: IL-23/IL-22/IL-18 axis
subject: Apoptosis
subject: Bacterial translocation
subject: Mucin-2
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Campylobacter jejuni infections are of rising importance worldwide. Given that innate immune receptors including nucleotide-oligomerization- domain-2 (Nod2) are essentially involved in combating enteropathogenic infections, we here surveyed the impact of Nod2 in murine campylobacteriosis. Methods and results In order to overcome physiological colonization resistance preventing from C. jejuni infection, we generated secondary abiotic Nod2−/− and wildtype (WT) mice by broad-spectrum antibiotic treatment. Mice were then perorally infected with C. jejuni strain 81-176 on 2 consecutive days and could be stably colonized by the pathogen at high loads. Notably, Nod2 deficiency did not affect gastrointestinal colonization properties of C. jejuni. Despite high intestinal pathogenic burdens mice were virtually uncompromised and exhibited fecal blood in single cases only. At day 7 postinfection (p.i.) similar increases in numbers of colonic epithelial apoptotic cells could be observed in mice of either genotype, whereas C. jejuni infected Nod2−/− mice displayed more distinct regenerative properties in the colon than WT controls. C. jejuni infection was accompanied by increases in distinct immune cell populations such as T lymphocytes and regulatory T cells in mice of either genotype. Increases in T lymphocytes, however, were less pronounced in large intestines of Nod2−/− mice at day 7 p.i. when compared to WT mice, whereas colonic numbers of B lymphocytes were elevated in WT controls only upon C. jejuni infection. At day 7 p.i., colonic pro-inflammatory mediators including nitric oxide, TNF, IFN-γ and IL-22 increased more distinctly in Nod2−/− as compared to WT mice, whereas C. jejuni induced IL-23p19 and IL-18 levels were lower in the large intestines of the former. Converse to the colon, however, ileal concentrations of nitric oxide, TNF, IFN-γ, IL-6 and IL-10 were lower in Nod2−/− as compared to WT mice at day 7 p.i. Even though MUC2 was down-regulated in C. jejuni infected Nod2−/− mice, this did not result in increased pathogenic translocation from the intestinal tract to extra-intestinal compartments. Conclusion In secondary abiotic mice, Nod2 signaling is involved in the orchestrated host immune responses upon C. jejuni infection, but does not control pathogen loads in the gastrointestinal tract.
Datenmanagement
Creators: name: Haase, Robert
Publisher: name: Zenodo
Year: 2024

description: In dieser Data Management Session wird der Lebenszyklus von Daten näher beleuchtet. Wie entstehen Daten, was passiert mit ihnen, wenn sie verarbeitet werden? Wem gehören die Daten und wer ist dafür verantwortlich, sie zu veröffentlichen, zu archivieren und gegebenenfalls wiederzuverwenden? Wir werden einen Datenmanagementplan in Gruppenarbeit entwerfen, ggf. mit Hilfe von ChatGPT.
"Hello Mrs. Scribbles": Storytelling, identity and teacher research in the kindergarten.
Creators: name: Stewart, Sandra Rae.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Education, Early Childhood.

description: Using the framework of critical ethnography, one that offers an insider's view to understanding processes, I entered my own kindergarten classroom and tried to place my own storytelling pedagogy under critical scrutiny. I tried to find answers to such questions as: (1) what impact my storytelling praxis had on the identity of the children, (2) how my teacher belief about storytelling and literacy learning of young children informed my classroom praxis and (3) how the children responded to this praxis. This research was conducted over ten weeks in 1994 in a small English speaking school in a mid-sized city in central Canada. Forty-two children took part in the study; twenty-five were five years old and seventeen were four years old. Twenty-six of the children were English speaking. Sixteen children were from ethnically diverse backgrounds. Each week I told the children one story, taken from my annual "Fairy Tale and Nursery Rhyme" theme. I taperecorded these tellings and demonstrated the use of the taperecorder for the children. The taperecorder was then made available to the children and they were encouraged to go and tell their own stories into it. During this time I also collected field notes and kept a reflective journal. An analysis of the data revealed a storytelling praxis rife with problems. The themes of the teacher-told stories offered a very narrow Eurocentric world view. Most child storytellers were five years old and had strong English skills. Four year old children or children with weak English skills tended to stay away from the taperecorder. Finally, while acting as both a teacher and a researcher is a creative means of bringing the classroom teacher's voice into the literature, it proved to be full of tension. (Abstract shortened by UMI.)
Kriterien zur Bewertung des Transformationspotentials von Nachhaltigkeitsinitiativen
Creators: name: Wunder, Stephanie
name: Albrecht, Stefanie
name: Porsch, Lucas
Publisher: name: My University
Year: 2019
Subjects: subject: Sozialer Wandel
subject: Nachhaltigkeitspolitik
subject: Gesellschaftliche Transformation
subject: Nische
subject: Mainstream
subject: Nachhaltigkeitsinitiativen
subject: Nachhaltigkeit | Strategien | Internationales

description: Den Mehrwert von Nachhaltigkeitsinitiativen sichtbar machen – Grundlagen für ein Bewertungstool Nachhaltigkeitsinitiativen und soziale Innovationen haben eine wichtige Funktion für den gesellschaftlichen Wandel zur ⁠Nachhaltigkeit⁠: In Tauschringen, in Repaircafés oder Foodsharinginitiativen zeigen sie, wie Nachhaltigkeit funktionieren kann. Viele dieser Initiativen befinden sich in der "Nische". Bei entsprechender (politischer) Unterstützung könnten sie jedoch gesellschaftliche Verbreitung finden.Hier setzt das Vorhaben an: Was ist genau der Mehrwert von Nachhaltigkeitsinitiativen und warum sind sie politisch unterstützenswert? In dem Vorhaben sind erstmals Kriterien entwickelt worden, um objektiv den Mehrwert dieser Initiativen für eine Transformation und für Nachhaltigkeit zu erfassen. Der Ansatz kann von der Bundesebene, der kommunalen Ebene, Förderinstitutionen, der Wissenschaft oder Nachhaltigkeitsinitiativen selbst genutzt werden.
Safety of Combined Treatment With Monoclonal Antibodies and Viscum album L Preparations
Creators: name: Schad, Friedemann
name: Axtner, Jan
name: Kröz, Matthias
name: Matthes, Harald
name: Steele, Megan L.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: adverse events
subject: combination therapy
subject: integrative oncology
subject: Helixor
subject: mistletoe
subject: Viscum album L
subject: safety
subject: targeted therapy
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik

description: Combination strategies involving chemotherapy and monoclonal antibodies (mAb) are commonly used in attempts to produce better clinical outcomes. This practice has led to new and ongoing toxicities that may lead to reductions in dose or noncompliance, limiting the effectiveness of treatment. Viscum album L (VA) preparations are widely used in Europe as additive therapy and have been associated with reduced chemotherapy-related adverse reactions and increased health-related quality of life. Concomitant VA therapy might also reduce toxicity related to mAb. This retrospective study investigated the safety of combined treatment with VA and mAb in cancer patients. A total of 43 patients had combined therapy (474 exposures); 12 had VA without mAb (129 exposures), and 8 had mAb without VA (68 exposures). Most patients (89.3%) received concomitant chemotherapy or supportive therapies. A total of 34 patients (60.7%) experienced 142 adverse events (AEs). Leucopenia (14.1% of all events), acneiform rash (8.5%), and stomatitis (6.3%) occurred most frequently. Longitudinal logistic regression analysis suggested a nearly 5 times higher odds of experiencing an AE following treatment with mAb compared with mAb plus VA (95% CI = 1.53-16.14). Our results, together with theoretical consideration of potential botanical-drug interactions, suggest that combined treatment with VA and mAb is safe.
title: RM fetal: Estudio de la patología torácica y abdómino-pélvica
Creators: name: Recio Rodríguez, Manuel
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Foetal imaging

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
INTRODUCCIÓN: La ecografía (US) es el método de estudio rutinario para el cribado de las anomalías fetales que incluso en manos experimentadas tiene limitaciones técnicas.
La mayoría de las ecografías son diagnósticas,
sin embargo estas...
title: NEUROFIBROMATOSIS: técnicas de estudio y hallazgos radiológicos fundamentales.
Creators: name: Sobrino Castro, Uxia
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Statistics
subject: FOS: Mathematics
subject: Ultrasound
subject: CT
subject: MR
subject: Neuroradiology peripheral nerve
subject: Neuroradiology brain

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Objetivo docente: A través de la revisión de todos los estudios de imagen realizados entre 2009 y 2011 en nuestro centro a los pacientes con diagnóstico confirmado de neurofibromatosis (tipo I y II),
el objetivo es revisar: - las técnicas de...
Perspectives of patients, first-degree relatives and rheumatologists on preventive treatments for rheumatoid arthritis: a qualitative analysis
Creators: name: Munro, Sarah
name: Spooner, Luke
name: Milbers, Katherine
name: Hudson, Marie
name: Koehn, Cheryl
name: Harrison, Mark (Assistant Professor)
Publisher: name: BioMed Central
Year: 2018

description: Background: There is growing evidence that it may be possible to identify people at high risk of developing rheumatoid arthritis (RA). Assuming that effective interventions were available, this could mean that treatments introduced in the pre-symptomatic phase could prevent or delay the onset of the disease. Our study aimed to identify the potential attributes involved in decision-making around whether or not to take preventive treatment for RA, in order to inform the development of a discrete choice experiment (DCE) to ascertain consumer preferences for a preventive treatment program for RA. Methods: We conducted a focus group study to develop conceptual attributes, refine their meaning, and develop levels. Participants included RA patients, first-degree relatives of RA patients, and rheumatologists who were 18 years of age and over, could read and speak English, and could provide informed consent. Candidate attributes were refined through iterative rounds of data collection and analysis. All focus groups were audio-recorded and transcribed, and then analyzed using the Framework Method to identify, compare, and contrast key conceptual attributes. Results: Attributes identified from analysis included: accuracy of the test, certainty in estimates, method of administration, risk of RA and risk of reduction with treatment, risk and seriousness of side effects, person recommending the test, and opinion of the health care professional. Patients with RA, first-degree relatives of patients, and rheumatologists all valued the accuracy of testing due to concerns about false positives, and valued certainty in estimates of the test and preventive treatment. Patients and first-degree relatives desired this evidence from a range of sources, including discussions with people with the disease and health care professionals, and their preferences were modified by the strength of recommendation from their health care professional. Conclusions: The role of the person who recommends a test and the opinion of a health care professional are novel potential attributes involved in decisions around whether or not to take preventive treatment for RA, that have not been included in previous DCEs.
title: La comunicación entre residentes de Radiodiagnóstico en España. ¿Dónde estamos? ¿Hasta dónde podemos llegar?
Creators: name: Amador Gil, Alberto
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Education
subject: Computer applications
subject: Management
subject: Teleradiology

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Mostrar el estado actual de la comunicación entre los residentes de Radiodiagnóstico a nivel de España y los beneficios a nivel formativo y de relación interpersonal que podría aportar una mejora en las...
An Evaluation of the Extrinsic Stressors Impacting Pacific Herring, Clupea pallasi, Spawn in False Creek
Creators: name: Ahmed, Molly
name: Dykstra, Natalie
name: Janowicz, Allie
name: Lam, Samantha
Publisher: name: The University of British Columbia
Year: 2025

description: Pacific Herring, Clupea pallasi, are essential forage fish along the Northwest Pacific Coast that have always played a crucial role in B.C.'s economy and in the livelihoods of coastal indigenous Peoples. False Creek has historically provided spawning habitat for herring and other species prior to colonisation, urban infill and development. To address the ecological degradation of False Creek, the Squamish Streamkeepers are supporting the reestablishment of herring populations by providing alternative spawning substrate. This is the 5th year of UBC ENVR 400 student involvement in the project. Our goal is to inform management decisions by collecting, analysing, and interpreting data. Our project objectives were to 1) Synthesise all previous ENVR 400 False Creek Herring reports and build an infographic to be shared to build awareness of herring in False Creek. 2) Monitor the 2025 herring spawn and compare it to previous iterations. 3) Evaluate how light exposure and cleaning impacts algal build-up on nets at Fisherman's Wharf. 4) Determine how the conductivity and temperature profiles at Fisherman's Wharf change annually and during the anticipated spawning period. 5) Investigate if 6PPD-Quinone is present in Fisherman’s Wharf. 6) Develop a lab protocol for a 6PPD-Quinone exposure experiment on herring egg development. We found that conductivity and temperature at our study sight was impacted by tidal fluxes, seen by daily fluctuations, and the water temperature was below the ideal spawning range for herring during the anticipated spawning period. Nets that were not cleaned had dense algae coverage, but the effects of algae growth on spawn could not be assessed due to the lack of spawn. Trace concentrations of 6PPD-Q were found in surface samples, but not at depth with 6 out of 14 samples had traces of 6PPD-Q. The sample with the maximum concentration found was collected after a rain event and was 3.37 ng/L. There were some speculations behind low spawn including an increase in predator populations, an increase in catch limit for Food and Bait fisheries in the Strait of Georgia which target resident, pre-spawning populations, sewer construction by the study site and colder and drier temperatures during the spawning period.
Breaking Toxic Triangles: How Courageous Followers stand up to Destructive Leadership
Creators: name: de Sales, Alain
Publisher: name: Swinburne
Year: 2024

description: Destructive leadership is a growing phenomenon with very real consequences. The scant work that exists largely focuses on destructive leaders while discounting the role of followers and contexts. Using theories on power, agency and structure, this study analyses the actions and discourses undertaken by courageous followers to shift the power balance while attempting to collapse Toxic Triangles (i.e., the confluence of a destructive leader, susceptible followers and the environment). This transdisciplinary study covers 70 episodes across diverse domains within mass movements, politics, and business. The findings have important implications for how we can challenge destructive leaders and democratise our workplaces.
Exploring the impact of muti-site data acquisition parameters on deep learning models for fMRI data
Creators: name: Saeed, Fahad
name: Almuqhim, Fahad
Publisher: name: Zenodo
Year: 2023

description: 1.  Our results demonstrate that multisite datasets, such as ABIDE-I in this case, can still show site specific effects even after data preprocessing, which can lead to suboptimal classification results.2. Our results also show that the machine-learning models may be learning site-specific variations in the patterns that may not be specific to the ASD biomarkers and requires further investigation.
Dynamique de l'organisation écologique d'un paysage rural du comté de Dundas.
Creators: name: Séguin, Joanne F.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Urban and Regional Planning.

description: The goal of this thesis is to establish if the dynamic model of ecological organization at a distance reflect the same influence or different influences than the ones which acted upon the areas in the vicinity of the city. In order to accomplish this, existing studies of Phipps, Baudry and Burel measuring the ecological organization of a rural landscape in two segments submitted to a low urban pressure (between 1 Km and 10 Km from the city) and high urban pressure (less than 1 Km to the city) will be used. The problem is seen from a landscape point of view, from the organization measured in time and from the variable effect of the urban pressure. With the results of this study, we should be able to complete the picture of the study of the dynamic of the ecological organization of a landscape in view of the distance to the urban center. (Abstract shortened by UMI.)
title: Nociones y detalles básicos para crear un archivo docente en el servicio de Radiodiagnóstico.
Creators: name: Amador Gil, Alberto
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Computer applications
subject: Education
subject: PACS
subject: Teleradiology

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Mostrar de forma clara y comprensible cómo crear un archivo docente en aquellos servicios que aún no dispongan de uno.
Exponer nociones básicas de teoría de redes,
bases de datos,
configuración de servidores y servicios web adaptados al...
title: Alteraciones focales de la señal de la médula ósea de los cuerpos vertebrales: Hallazgos en RM y diagnóstico diferencial.
Creators: name: Sales Fernandez, Covadonga
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Metastases
subject: Infection
subject: Haemangioma
subject: MR

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
Describir las alteraciones focales más frecuentes de la señal de la médula ósea de los cuerpos vertebrales normales y patológicas.
Establecer el diagnóstico diferencial entre las lesiones patológicas y aquellas que “no hay que tocar” e...
Polystyrylboronic acid: A new polymeric protecting group for the selective functionalization of polyols.
Creators: name: Moffatt, Elizabeth Seymour.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1977
Subjects: subject: Chemistry, Polymer.

description: A regenerable polystyrylboronic acid resin has been prepared for the selective functionalization of polyols. The resin reacts with a diol group of a polyol to form a resin-bound cyclic boronate. Both the coupling and cleavage steps are performed under very mild conditions (removal or addition of water) and the resin is regenerated directly by the cleavage step. Monoacyl derivatives of some acyclic polyols and some partially acylated carbohydrate derivatives have been prepared efficiently on the resin without the need for any purification of intermediates. In addition, the polystyrylboronic acid resin which exhibits a high selectivity for cis diol systems, can be used in the separation of cis and trans diol mixtures such as the cyclohexanediols by affinity chromatography.
Specification-based regression testing measurement with risk analysis
Creators: name: Chen, Yanping
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Computer Science.

description: Regression testing is essential to ensure software quality. A test team applies a regression test suite to ensure that new or modified features do not regress (make worse) existing features. Code-based regression test selection is good for unit testing, but it has a scalability problem. When the size of the object under test grows, it becomes hard to manage all relevant Risk Exposure information and to create corresponding traceability matrices for validation and coverage assessment. We propose a scalable alternative, namely a specification-based method for regression test selection. There are three major parts of our work: First, we propose and justify a new, specification-based regression test strategy built on two complementary test coverage goals, namely coverage of modified features, and "affected entities" (Targeted Coverage), and additional, complementary coverage of functional areas of risk (Safety Coverage). Secondly, we provide systematic methods for selecting these two types of regression test cases. Finally, to evaluate our approach, we use data from a real software product to do case studies. (Abstract shortened by UMI.)
title: Infecciones Enfisematosas en el abdomen y pelvis: hallazgos radiológicos y diagnóstico diferencial.
Creators: name: Borrego Gómez, Jesús
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Infection
subject: Imaging sequences
subject: Localisation
subject: Image compression
subject: Ultrasound
subject: Conventional radiography
subject: CT-High Resolution
subject: Education
subject: Pelvis
subject: Abdomen
subject: Abscess
subject: Tissue characterisation

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Reconocer la importancia de la patología enfisematosa en el abdomen. Mostrar las manifestaciones radiológicas más características de las infecciones enfisematosas abdominopélvicas. Revisar la infecciones enfisematosas abdominopélvicas más...
Managing Feelings of Incompetence in Supervision: A Modified Grounded Theory Study of Counselling Interns
Creators: name: Nyiri, Anna
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Education, Guidance and Counseling.
subject: Psychology, Counseling.

description: Feelings of incompetence (FOI) are a pervasive self-care issue for practitioners of psychotherapy, independent of their levels of experience (Theriault & Gazzola, 2008). Supervision may be an effective strategy for alleviating the impact of FOI; however, it is unclear how FOI are managed in supervision and how therapists experience their struggles with FOI in the context of supervision. The researcher conducted semi-structured interviews with six Master's level counselling interns (5 female, 1 male) who were receiving individual supervision. A modified grounded theory analysis (Corbin & Strauss, 2008) yielded five major categories: Properties of Intern FOI that Required Management in and/or out of Supervision, Actions of the Intern that Pertain to the Management of FOI in Supervision, Attributes of the Intern That Influence FOI-Management in Supervision, Aspects of Supervision That are Helpful to the Management of FOI, and Aspects of Supervision That Hinder the Management of FOI. Implications for counsellor supervisors, counsellor educators, and counselling interns themselves are discussed.
Corticotropin-releasing factor overexpression in mice abrogates sex differences in body weight, visceral fat, and food intake response to a fast and alters levels of feeding regulatory hormones
Creators: name: Wang, Lixin
name: Goebel-Stengel, Miriam
name: Yuan, Pu-Qing
name: Stengel, Andreas
name: Tache, Yvette
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Corticotropin-releasing factor overexpressing (CRF-OE) male mice showed an inhibited feeding response to a fast, and lower plasma acyl ghrelin and Fos expression in the arcuate nucleus compared to wild-type (WT) mice. We investigated whether hormones and hypothalamic feeding signals are impaired in CRF-OE mice and the influence of sex. Methods Male and female CRF-OE mice and WT littermates (4–6 months old) fed ad libitum or overnight fasted were assessed for body, adrenal glands and perigonadal fat weights, food intake, plasma hormones, blood glucose, and mRNA hypothalamic signals. Results Under fed conditions, compared to WT, CRF-OE mice have increased adrenal glands and perigonadal fat weight, plasma corticosterone, leptin and insulin, and hypothalamic leptin receptor and decreased plasma acyl ghrelin. Compared to male, female WT mice have lower body and perigonadal fat and plasma leptin but higher adrenal glands weights. CRF-OE mice lost these sex differences except for the adrenals. Male CRF-OE and WT mice did not differ in hypothalamic expression of neuropeptide Y (NPY) and proopiomelanocortin (POMC), while female CRF-OE compared to female WT and male CRF-OE had higher NPY mRNA levels. After fasting, female WT mice lost more body weight and ate more food than male WT, while CRF-OE mice had reduced body weight loss and inhibited food intake without sex difference. In male WT mice, fasting reduced plasma insulin and leptin and increased acyl ghrelin and corticosterone while female WT showed only a rise in corticosterone. In CRF-OE mice, fasting reduced insulin while leptin, acyl ghrelin and corticosterone were unchanged with no sex difference. Fasting blood glucose was higher in CRF-OE with female > male. In WT mice, fasting increased hypothalamic NPY expression in both sexes and decreased POMC only in males, while in CRF-OE mice, NPY did not change, and POMC decreased in males and increased in females. Conclusions These data indicate that CRF-OE mice have abnormal basal and fasting circulating hormones and hypothalamic feeding-related signals. CRF-OE also abolishes the sex difference in body weight, abdominal fat, and fasting-induced feeding and changes in plasma levels of leptin and acyl ghrelin.
Structure and reactivity of silica-supported chromium(IV) complexes.
Creators: name: Amor Nait Ajjou, Jamila.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Chemistry, Inorganic.

description: This thesis has been divided into four major sections. The first section deals with the reactions of CrR4 (R is neopentyl or trimethylsilylmethyl) with the surfaces of partially dehydroxylated silicas, leading to the formation of discrete mononuclear surface organometallic fragments. The reaction stoichiometry was found to depend on the density of surface hydroxyl groups. On silica subjected to prior dehydroxylation at 500°C, one Cr is grafted per hydroxyl group and one equiv. of alkane is evolved, leaving ≡SiOCrR3 on the surface. On silica dehydroxylated at 200°C, each Cr is grafted onto two hydroxyl groups and two equiv. of alkane are evolved, giving (≡SiO) 2CrR2. When CrR4 reacts with deuterated hydroxyl groups, monodeuteroalkane is liberated. The chemisorbed Cr species retain the oxidation state (IV) and nuclearity (mono-) of their parent molecular precursors. The second section examines the thermal transformations of silicasupported (≡SiO)2Cr(CH2CMe3)2, which undergoes a clean reaction at 69°C to generate a supported alkylidene complex, (≡SiO)2Cr=CHCMe3, with concurrent liberation of CMe4. The reaction is quantitative and kinetically first-order. Isotope-labeling and kinetics experiments support a mechanistic assignment of intramolecular alpha-H abstraction. The temperature dependence of the first-order rate constants is consistent with a two-step mechanism of reversible (alkyl)(alkyhdene)Cr(VI) hydride formation followed by reductive elimination of alkane. Reactions with acetone and Br2 are consistent with the alkylidene formulation. A related alkylidene complex was prepared by thermolysis of silicasupported (≡SiO)2Cr(CH2SiMe3) 2 at 150°C. The third section describes the reactions of supported alkylidenes with various olefins. In contrast to silica-supported bis(neopentyl)Cr(IV), the surface alkylidene complexes are efficient room temperature alpha-olefin polymerization catalysts. Based on kinetic and isotope effects, a mechanism of agostic-assisted migratory insertion is proposed for the propagation step. The overall oxidation state of the Cr remains (IV) during the reaction. The last part of this thesis deals with the study of silica-supported amido and alkoxo chromium complexes. The reactions of Cr(NEt2) 4 and Cr(OtBu)4 with the partially dehydroxylated silica surface at 200°C give exclusively (≡SiO)2Cr(NEt 2)2 and (≡SiO)2Cr(OtBu) 2, respectively. Both surface organometallic complexes undergo ligand exchange reactions with alcohols. Thermal treatment of (≡SiO)2 Cr(OtBu)2 followed by addition of benzyl alcohol shows evidence for oxidation to benzoic acid. However, the "Cr=O" intermediate has yet to be detected.
title: Radiología de la patología ginecológica en urgencias
Creators: name: Mas Gelabert, Miguel
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Pathology
subject: Diagnostic procedure
subject: Ultrasound-Colour Doppler
subject: Ultrasound
subject: CT
subject: Genital / Reproductive system female
subject: Emergency

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Uno de los problemas que más frecuentemente se le plantean almédico de urgencias,
es la valoración de un dolor abdominalbajoen una paciente mujer en edad fértil.
Nuestro objetivo esconocer la eficacia de los metodos de imagenen el diagnóstico...
title: Escala de   Ginebra: ¿cual es su  valor predictivo para angioTC positiva  en la urgencia?
Creators: name: Martí De Gracia, Milagros
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Embolism / Thrombosis
subject: Diagnostic procedure
subject: Efficacy studies
subject: CT-Angiography
subject: Thorax
subject: Emergency

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
Introducción El tromboembolismo pulmonar (TEP) es una patología que constituye la tercera causa de mortalidad en nuestro país y se que se encuentra asociada a una marcada morbilidad,
sobre todo la hipertensión pulmonar (Monreal et al.,
2006)....
Daviault, drunkenness, and discourse: The social construction of the drunkenness defence as a feminist issue.
Creators: name: Frieday, Karen Yvonne.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Sociology, Criminology and Penology.

description: As part of an overall move towards protecting the public (especially those felt to be most vulnerable, e.g. women and children), legislation has recently been tabled which would forbid the use of a defence based on self-induced extreme intoxication producing a state akin to automatism (the drunkenness defence) in trials of general intent offences. This legislation (Bill C-72, s. 33.1), is in direct conflict with the 1994 ruling of the Supreme Court of Canada in Daviault in which the majority found that to deny such a defence in general intent cases was in violation of the principles of fundamental justice enshrined in our Charter of Rights and Freedoms. The Supreme Court of Canada decided that the common-law precedents set by cases such as Beard, Majewski, and Leary, which did not allow evidence of extreme intoxication in general intent cases, had the effect of convicting individuals for crimes in which they were lacking the necessary mens rea or voluntariness. It is proposed that Bill C-72 was tabled in response to feminist claims-making, in addition to the public, and media outcry raised by the Daviault case. (Abstract shortened by UMI.)
ATP Synthase Deficiency due to TMEM70 Mutation Leads to Ultrastructural Mitochondrial Degeneration and Is Amenable to Treatment
Creators: name: Braczynski, Anne K.
name: Vlaho, Stefan
name: Müller, Klaus
name: Wittig, Ilka
name: Blank, Anna-Eva
name: Tews, Dominique S.
name: Drott, Ulrich
name: Kleinle, Stephanie
name: Abicht, Angela
name: Horvath, Rita
name: Plate, Karl H.
name: Stenzel, Werner
name: Goebel, Hans H.
name: Schulze, Andreas
name: Harter, Patrick N.
name: Kieslich, Matthias
name: Mittelbronn, Michel
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie

description: TMEM70 is involved in the biogenesis of mitochondrial ATP synthase and mutations in the TMEM70 gene impair oxidative phosphorylation. Herein, we report on pathology and treatment of ATP synthase deficiency in four siblings. A consanguineous family of Roma (Gipsy) ethnic origin gave birth to 6 children of which 4 were affected presenting with dysmorphic features, failure to thrive, cardiomyopathy, metabolic crises, and 3-methylglutaconic aciduria as clinical symptoms. Genetic testing revealed a homozygous mutation (c.317-2A>G) in the TMEM70 gene. While light microscopy was unremarkable, ultrastructural investigation of muscle tissue revealed accumulation of swollen degenerated mitochondria with lipid crystalloid inclusions, cristae aggregation, and exocytosis of mitochondrial material. Biochemical analysis of mitochondrial complexes showed an almost complete ATP synthase deficiency. Despite harbouring the same mutation, the clinical outcome in the four siblings was different. Two children died within 60 h after birth; the other two had recurrent life-threatening metabolic crises but were successfully managed with supplementation of anaplerotic amino acids, lipids, and symptomatic treatment during metabolic crisis. In summary, TMEM70 mutations can cause distinct ultrastructural mitochondrial degeneration and almost complete deficiency of ATP synthase but are still amenable to treatment.
title: MENINGIOMA ATÍPICO: Espectro radiológico y correlación con hallazgos de Anatomía patológica.
Creators: name: Ortega Quintanilla, Joaquin
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Neoplasia
subject: CT
subject: MR-Diffusion/Perfusion
subject: MR
subject: Oncology
subject: Neuroradiology brain

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Ilustrar las diferentes manifestaciones radiológicas que orientan hacia el diagnóstico de meningioma atípico,
mostrando correlación anatomo-patológica. Realizamos revisión de 44 casos diagnosticados (con confirmación anatomopatológica y...
Investigating the Detectability of Axion Quark Nugget Dark Matter Emission in Modern Telescopes
Creators: name: Scully, Benjamin Peter
Publisher: name: The University of British Columbia
Year: 2025

description: The axion quark nugget dark matter model offers a solution to both the dark matter and matter-antimatter asymmetry problems observed in our universe. As a sparsely distributed dark matter model with a non-negligible emission mechanism, the most promising avenue of detection lies in astronomical observation. In this thesis, the thermal emission of axion quark nuggets is simulated on cosmological scales and directly compared to observational limits of the Euclid Telescope and James Webb Space Telescope. We find that certain mass ranges of axion quark nuggets produce emission which lies in a theoretically detectable region of both telescopes while not being ruled out by existing observations. This opens the door for the application of component separation techniques to achieve a dark matter detection in current-day telescope observations in the near future.
title: Afectación del mesenterio en el abdomen agudo: buscando el camino entre la niebla.
Creators: name: Iglesias Hidalgo, Gotzon
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Abdomen
subject: CT

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
1.
Conocer el diagnóstico diferencial de las lesiones que condicionan una afectación del mesenterioen el abdomen agudo. 2.
Reconocer las manifestaciones en la TC de las distintas patologías que lo pueden presentar. 3.
Identificar los hallazgos en...
The Effects of Delayed Visual Feedback on Postural Dynamics
Creators: name: Boulet, Jason
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Biophysics, Biomechanics.

description: We report on experiments and modeling of the interactions between delayed visual feedback and postural control in human quiet stance. A heuristic model is derived based on physiological and psychophysical parameters. The level of agreement found between the data and the model was found to be very good for power spectral densities, probability density functions and mean-squared displacements (or Hurst exponents). The stochastic delayed differential model identifies critical time scales of postural corrections. We also investigate properties of the model such as stability, small delay approximations and the power spectral density. Lastly, we use nonlinear time series techniques to investigate the temporal structure of the experimental postural dynamics. We propose the first dynamical model of visually assisted posture control.
Participant, peer and PEEP: considerations and strategies for involving people who have used illicit substances as assistants and advisors in research
Creators: name: Greer, Alissa M.
name: Amlani, Ashraf
name: Pauly, Bernadette
name: Burmeister, Charlene
name: Buxton, Jane A.
Publisher: name: BioMed Central
Year: 2018

description: Background: The Peer Engagement and Evaluation Project (PEEP) aimed to engage, inspire, and learn from peer leaders who represented voices of people who use or have used illicit substances, through active membership on the ‘Peeps’ research team. Given the lack of critical reflection in the literature about the process of engaging people who have used illicit substances in participatory and community-based research processes, we provide a detailed description of how one project, PEEP, engaged peers in a province-wide research project. Methods: By applying the Peer Engagement Process Evaluation Framework, we critically analyze the intentions, strategies employed, and outcomes of the process utilized in the PEEP project and discuss the implications for capacity building and empowerment among the peer researchers. This process included: the formation of the PEEP team; capacity building; peer-facilitated data collection; collaborative data analysis; and, strengths-based approach to outputs. Results: Several lessons were learned from applying the Peer Engagement Process Evaluation Framework to the PEEP process. These lessons fall into themes of: recruiting and hiring; fair compensation; role and project expectations; communication; connection and collaboration; mentorship; and peer-facilitated research. Conclusion: This project offers a unique approach to engaging people who use illicit substances and demonstrates how participation is an important endeavor that improves the relevance, capacity, and quality of research. Lessons learned in this project can be applied to future community-based research with people who use illicit substances or other marginalized groups and/or participatory settings.
title: Masas pélvicas inusuales en RM; Sarcomas uterinos.
Creators: name: Gil Martín, Ana
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Genital / Reproductive system female
subject: Oncology
subject: MR
subject: Chemotherapy
subject: Neoplasia

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Objetivos docentes: Analizar la presentación clínica,
las características anatomopatológicas y radiológicas de la serie de sarcomas uterinos de nuestro hospital. Establecer las secuencias y protocolos más adecuados para el estudio de esta...