cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Author_Response_2 – Supplemental material for Patterns and predictors of low physical activity in patients with stable COPD: a longitudinal study
Creators: name: Sánchez-Martínez, María Piedad
name: Bernabeu-Mora, Roberto
name: García-Vidal, Jose Antonio
name: Benítez-Martínez, Josep
name: Oliveira-Sousa, Silvana Loana De
name: Medina-Mirapeix, Francesc
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine
subject: 110203 Respiratory Diseases

description: Supplemental material, Author_Response_2 for Patterns and predictors of low physical activity in patients with stable COPD: a longitudinal study byMaría Piedad Sánchez-Martínez, Roberto Bernabeu-Mora, Jose Antonio García-Vidal, Josep Benítez-Martínez, Silvana Loana de Oliveira-Sousa and Francesc Medina-Mirapeix in Therapeutic Advances in Respiratory Disease
Mutational Signatures as Biomarkers of Carcinogen Exposure Among Female Firefighters
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: The International Agency for Research on Cancer (IARC) classifies firefighting as a known human carcinogen based on evidence of a causal association between working as a firefighter and developing cancer. Firefighter cancer research has focused on male cohorts, with little study of women. However, in epidemiological studies that included some female firefighters, nearly half of all cancers were breast cancers and breast cancer incidence was higher than in the general public. Hence, our team is studying the exposures and biological mechanisms that increase breast cancer risk among female firefighters. Measuring early biomarkers of cancer can help identify causes, and new methods are needed. In its 2023 Monographs, IARC noted strong mechanistic evidence of DNA damage (genotoxicity) associated with occupational exposure as a firefighter. This is unsurprising because products of combustion are genotoxic, however there are likely other important exposures contributing to mutations and breast cancer. Since mutations are an intermediate step between DNA damage and cancer, and can also result from non-genotoxic processes, assessing mutations may provide a more predictive biomarker for cancer risk. We propose to measure the burden and patterns of mutations associated with firefighting using two comparisons: 1) female firefighters compared to matched office workers and 2) female firefighters at recruitment baseline and after 2-3 years of firefighting. Using novel and highly accurate error-corrected DNA sequencing technology, we will measure mutation frequency and identify mutational signatures overrepresented among firefighters. We will compare these signatures to a reference database and our previous exposure measurements to predict which occupational exposures most likely caused the mutations. To further refine predictions of mutagenic chemicals in smoke, we will use computational approaches to model DNA lesions caused by this class of chemicals. Our research supports breast cancer prevention by applying a novel technology to identify early biomarkers predictive of risk. Our team will support firefighter risk reduction throughout the project. Findings will be published in peer-reviewed journals and disseminated to the fire service and study participants, providing a scientific basis for interventions to reduce breast cancer risk among women firefighters.
Identifying Pathogen Exposures that Ignite Breast Cancer Risk and Lethality
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: It is not known how people become at risk for developing breast cancer, as many exposures to breast cancer carcinogens are difficult to trace. We hypothesize that exposure to pathogens cause breast cancer and breast cancer lethality. This is because pathogens, particularly those that establish infection in the breast, demonstrate many carcinogenic qualities such as driving chronic inflammation and mutations to the DNA. Yet, research has not been conducted to learn which types of infection act as carcinogens and put populations at risk for breast cancer and breast cancer being lethal. Our lab has designed an innovative multi-omics pipeline to trace infections with pathogens that act as carcinogens in clinical trial datasets. This is important because these exposures are frequent and pathogen exposures initiate cancer hallmarks and change the types of treatments that would work for patients. Our study recruits patients who have infection and breast cancer; which allows us to specifically study at risk patients. Our novel preclinical studies of breast cancer and infection will show us how exposure to pathogens can cause breast cancer hallmarks and lethality. In our study we test and deliver new concepts for preventative strategies to minimize risk of breast cancer by blocking pathogen driven cancer hallmarks like tumor promoting inflammation and tumor blood vessel formation eliminate cancer risk. We also design novel combination immune checkpoint treatments and use them with interventions specific for comorbid infection. This is important because these patients have diminished immune function– but no studies have been done on how to restore the ability of their immune system to recognize and kill breast cancer cells. We close this gap by delineating treatments that restore anti-tumor and anti-pathogen immune function. As an outcome of these results and this study, we will impact breast cancer prevention, treatment, community engagement, and political policy by providing clear data on which types of infectious exposures put people at risk for lethal breast cancer. Therefore, this study will motivate action to implement new concepts for how breast cancer initiates and progresses and effective prevention and treatment strategies to block the ability of pathogens to cause breast cancer or make breast cancer lethal.
Additional file 2 of Genetic association analysis of dietary intake and idiopathic pulmonary fibrosis: a two-sample mendelian randomization study
Creators: name: Zhang, Chenwei
name: Xi, Yujia
name: Zhang, Yukai
name: He, Peiyun
name: Su, Xuesen
name: Fan, Fangfang
name: Wu, Min
name: Kong, Xiaomei
name: Shi, Yiwei
Publisher: name: figshare
Year: 2024
Subjects: subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Mental Health
subject: Plant Biology

description: Additional file 2. STROBE-MR Table.
Disrupting Breast Cancer Metastasis with compound #26 via Myo10 - Integrin Interaction Targeting
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Fighting Breast Cancer: A New Frontier in Stopping Cancer Spread Breast cancer metastasis, where cells spread from a primary site to other parts of the body, is a major challenge in cancer treatment. Imagine cancer cells as tiny invaders that navigate through the body, seeking new territories. What if we could interfere with their navigation system, making it harder for them to spread? Our project is at the forefront of this exciting possibility, focusing on breast cancer, a type that affects millions worldwide and is the most common cancer in women in the US. Our research focuses on filopodia, cellular "fingers" guiding movement through tumor-surrounding areas. These "fingers" help cancer cells decide where to move, especially through the dense and stiff areas around tumors. Our goal is to find a way to halt these fingers, stopping breast cancer cells from moving and spreading. Our team has discovered a promising substance, which we refer to as #26, that can do just that. It targets and blocks the action of filopodia, showing great potential in preventing the spread of breast cancer cells without harming the body's healthy cells. This discovery could revolutionize how we approach breast cancer treatment, offering hope for strategies that prevent cancer from reaching other body parts. How are we doing this? Through a series of experiments that combine biology and chemistry, we are testing how well #26 can stop breast cancer cells in their tracks and exploring how #26 affect cancer cells' ability to sense and respond to their environment, aiming to understand exactly how they work. What makes our project innovative is the discovery of #26, and our approach in studying its effects and potential. If successful, we could identify new treatments that specifically target the ability of cancer cells to spread, opening up new avenues for preventing metastasis in breast cancer. The impact of our work could be significant, offering new hope for treatments that go beyond current methods, focusing on stopping cancer from spreading rather than just shrinking tumors. Our research is a step toward a future where breast cancer can be effectively contained, reducing the threat they pose to patients worldwide.
A targeted approach to eliminate metastatic tumor cells to inhibit TNBC metastasis
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Triple Negative Breast Cancer (TNBC) representing ~15 % of breast cancer types, is the most aggressive with a high likelihood of spreading to other organs (metastasis), causing 150,000 deaths worldwide, and ~30% of all breast cancer-related deaths. TNBC frequently recurs after standard breast cancer treatment. Few targeted treatments are available for TNBC, and they are limited in scope and effectiveness, and have adverse side effects. Thus, there is an urgent clinical need to develop new targeted therapies that would prevent metastasis and benefit many women with TNBC. We have identified a protein, t-SATB1, that we hypothesize to be a promising target for TNBC therapy based on the following innovative discoveries. We found that this protein is expressed specifically in breast cancer cells with high metastatic activity, and not in healthy cells. We identified a specific messenger RNA (mRNA) that cells use to produce this protein and devised a method to specifically degrade this mRNA to eliminate this protein in metastatic breast cancer cells. Indeed, this method readily kills TNBC cells grown in cell culture, showing that tumor cells can be effectively eliminated. Further, when we injected TNBC cells into the blood stream of mice, our targeted-elimination method blocked TNBC cells from growing in the lungs to form new tumors in mice, preventing metastasis. Using an approach called “xenograft,” we propose to implant piece of human tumor donated by TNBC patients in the breast of mice and test the efficacy of our approach. We hypothesize that t-SATB1 elimination will block metastasis. We will also monitor safety of our approach by studying any side effects, both at the organism health level as well as at the gene expression level. Because the targeted protein is not present in normal cells, we expect that side effects will be minimal. If our research is successful, we anticipate that our approach may lay the critical groundwork to develop a new type of targeted therapy for TNBC to effectively block metastatic recurrence while minimizing adverse effects of treatment, thus saving many lives. Because t-SATB1 is found in other types of aggressive breast cancers, we anticipate that our approach may be readily applied more broadly, and our antibody that detects t-SATB1 will be a useful diagnostic tool to identify patients who may benefit from this treatment.
Developing covalent PolQ inhibitors for targeted treatment of breast cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Targeted cancer therapy holds the promise to deliver effective and less toxic treatments to thousands of patients with breast cancer. A successful example is the use of PARP inhibitors to treat patients with harmful BRCA mutations. Unfortunately, even with targeted therapy, the development of drug resistance poses a significant challenge. Our research proposal aims to generate new therapeutics that will address this problem. DNA polymerase theta (POLQ) has emerged as a promising target for developing a new class of drugs for breast cancer treatment. POLQ levels are abnormally high in 70% of breast cancers, particularly those with poor prognosis, including the triple negative breast cancer. These tumor cells rely on POLQ to survive, especially under conditions of cell stress, whereas normal cells do not depend on POLQ for viability. We have shown that by inhibiting POLQ, we can also kill BRCA variant tumors that have acquired PARP inhibitor resistance. To become an effective treatment for patients, POLQ inhibitors still face the challenge of maintaining sufficient levels in the body to kill cancer cells. In this study, we will use a powerful new tool known as click chemistry (which is a pioneering method of joining molecules together to manufacture new drugs), developed by Dr. Barry Sharpless (2022 Nobel Prize Chemistry). With the addition of innovative PROTAC (Proteolysis Targeting Chimeras) technology, we plan to develop a new class of POLQ inhibitors that will provide long lasting and effective treatment. We have successfully identified promising new POLQ inhibitor leads and propose to further improve the potency and minimize potential side effects. We will test the efficacy of these new inhibitors in both cell-based assays and mouse breast cancer models. Our innovative approach to develop new types of POLQ inhibitors will yield compounds with high potency and prolonged duration, effectively addressing the current challenges associated with POLQ inhibition and enhancing the likelihood of success in clinical settings. The success of our study will pave the way for specific and effective targeted treatment for patients with breast cancer and has the potential to improve survival rates as well as quality of life.
Leveraging Radiomics and Artificial Intelligence with Mammography for Early Breast Cancer Detection
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Breast cancer (BCa) is the most common cancer among women, second only to skin cancer in the United States. Although the number of BCa deaths has decreased over time, it is still one of the most common causes of cancer-related deaths in women overall and the most common among Hispanic women. Early detection of BCa via screening programs has helped reduce mortality. Imaging modalities such as contrast enhanced mammography (CEM) and magnetic resonance imaging (MRI) have greatly improved BCa detection; however, these modalities are not suitable for routine screening due to high cost, limited availability or exposure to radiation and contrast agents. 2D mammography (2D MG) has been routinely used for BCa screening; however, it has a high false positive rate, a high false negative rate and cannot provide clinical insight until a lesion is visible on imaging, which limits early detection. Volumetric mammographic imaging of the breast using digital breast tomosynthesis (DBT) has been reported to improve BCa detection; however, DBT is associated with a higher radiation exposure to the patient. The increased availability of artificial intelligence (AI) and imaging informatics tools have made it possible to detect pre-malignancy signal and triage women with different risk profiles. In this proposed study, we will combine the strength of advanced image processing methods, AI and advanced statistical modeling, to derive an innovative biomarker: pre-malignancy index (PMI). By leveraging PMI, we can further construct a digital twin for breast health. Under this framework, we can aggregate health information including family history, lifestyle, genomic makeup, and observable physical traits to project the future trajectory of breast health. Furthermore, using digital twin framework based on PMI, we can monitor BCa risk and simulate responses from different lifestyle modifications in minimizing the risk of BCa.
RISE UP for Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: RISE UP (Revolutionizing Investigations to Link Screening to Experimental Therapeutics to Upend Prognosis for Breast Cancer) is a new conference that will bring an interdisciplinary, prevention-focused approach to the challenge of eliminating breast cancer mortality in our lifetime. The conference will bring together experts from a variety of backgrounds and disciplines, including (but not limited to!) physicians (oncology, surgery, obstetrics and gynecology, radiology, among others), basic scientists, advocates, entrepreneurs, policy makers, regulators, and venture capital/investment sector leaders from across the United States and the world. We will apply this wealth of varied expertise to three main focus areas: 1) new breast cancer subtypes and drugs/treatments that can be successfully used to get rid of tumors in the early-stage setting; 2) early endpoints (including imaging) and new trial designs that can accelerate learning, funding, and FDA approvals for treatment, screening and prevention; 3) highlight important research surrounding the biology of breast cancer and of the hormonal cycle control in women. As our understanding of breast cancer improves, we should use this knowledge to upgrade the hormonal control products that millions of women worldwide take over the course of their lifetime with a goal of reducing breast cancer incidence. The event will consist of poster sessions to highlight research as well as a series of speaker and discussion sessions. The conference is designed to foster questions, collaborations, and overall generation of new ideas and ways of thinking about breast cancer, with none of the sessions overlapping each other so people can attend everything they want to. The conference will be held over two and a half days (Thursday – Saturday) in Fall 2024 in San Francisco. We are especially excited about the city of San Francisco as the location for the event and hope that the can-do, entrepreneurial spirit of Silicon Valley will energize attendees to challenge the status quo and take action. We will build this notion of idea to implementation into the conference: we will hold a competition for the best idea for incorporating breast cancer prevention into the hormone-based OB/GYN care women already receive-- and a prize of working with Bay Area biotech and investment leaders to make that idea a reality.
Investigating the relationship between chemical exposures, DNA methylation, and breast cancer risk.
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: BACKGROUND Women are exposed to a wide array of toxic chemicals throughout their life course that are known to increase breast cancer risk (e.g.pesticides such as malathion). The research that has produced this evidence has been limited to studying one single chemical at a time. However, women are exposed to multiple chemicals simultaneously. It is unknown whether exposures to chemical mixtures have a larger effect on breast cancer risk than exposure to single chemicals. Biological markers (biomarkers) of exposure are needed to serve as an indication of past or current exposure. DNA methylation is a biomarker that changes in response to environmental exposures. DNA methylation is a reversible chemical process that regulates the activity of genes. HYPOTHESES 1. Exposure to mixtures of toxic chemicals is associated with higher risk for breast cancer compared to exposure to single chemicals 2. DNA methylation biomarkers can serve as a biomarker of exposure to chemical mixtures that increase breast cancer risk. METHODS We will measure the abundance of thousands of chemicals in archived blood samples of 300 women who developed breast cancer and 300 samples of women who did not. We will examine which chemicals have higher abundance in women who developed breast cancer. We will then create mixtures by grouping chemicals based on their impact on human health and other factors. We will then examine whether exposure to each mixture increases breast cancer risk and identify which of the chemicals in each mixture has the greatest impact on risk. All blood samples will also be sent for DNA methylation array analysis. We will then investigate whether there are specific DNA sites that are different among women with high total exposure to all the chemicals in a mixture and investigate which biological process are affected. IMPACT The findings can inform regulations on the use and release of toxic chemicals mixtures. DNA methylation biomarkers can be included in breast cancer risk models to find women at highest risk and intervene to reduce their risk.
MPEC 2024-K152 : 2018 VC
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Corradetti_et_al_Supplemental_Figure1 – Supplemental material for Bioactive Immunomodulatory Compounds: A Novel Combinatorial Strategy for Integrated Medicine in Oncology? BAIC Exposure in Cancer Cells
Creators: name: Corradetti, Bruna
name: Vaiasicca, Salvatore
name: Mantovani, Mauro
name: Virgili, Edy
name: Bonucci, Massimo
name: Ferri, Ivano Hammarberg
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: 111702 Aged Health Care

description: Supplemental material, Corradetti_et_al_Supplemental_Figure1 for Bioactive Immunomodulatory Compounds: A Novel Combinatorial Strategy for Integrated Medicine in Oncology? BAIC Exposure in Cancer Cells by Bruna Corradetti, Salvatore Vaiasicca, Mauro Mantovani, Edy Virgili, Massimo Bonucci and Ivano Hammarberg Ferri in Integrative Cancer Therapies
Coming Clean: Investigating the Impact of Cleaning Products & Breast Cancer on Domestic Workers
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: The Los Angeles based worker center, Institute of Popular Education of Southern California (IDEPSCA), seeks to address breast cancer risk factors of chemicals in consumer products and occupational factors by launching a Cleaning Product Systemic Intervention. With this planning grant, we would facilitate 3 collaborative educational sessions between policy partners, Breast Cancer Prevention Partners (BCPP), and IDEPSCA worker leaders to help understand the science behind toxic exposure in consumer products and the risk factors connected to breast cancer. There would be an additional listening session for immigrant Latina household workers cleaning private homes to share existing barriers in eliminating toxic cleaning products at work, as well as their overall perceptions about breast cancer risks. The goal would be to better understand what type of messaging and research would help encourage green cleaning products amongst workers and employers. Given the existing lack of health and safety protections for household workers in the country and ongoing efforts to eliminate the exclusion of domestic work from occupational health laws in California, the aim of this project is to provide more concrete recommendations to Cal OSHA on what implementation the Cleaning Product Right to Know for the Domestic Work Industry should look like. In 2017, the Cleaning Product Right to Know Act, also known as SB 258, passed in California, requiring consumer cleaning products sold in the state to disclose ingredients both online and on the product label. While an important step forward, the law did not adequately address the needs and concerns of domestic workers. Having a list of chemical names does not communicate the health risk domestic workers experience while using these products, often all day, 5 days a week or more. The information gap between what is on labels and what Domestic Workers need to know and understand about these products is what the educational sessions, and the potential longer term systemic interventions, are designed to address.
Drinking Water Contamination in California Central Valley and Central Coast
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: This project focuses on reducing water contamination in underserved regions of California, a theme that ranked as high importance for breast cancer prevention in Phase 1 of the Charting Paths to Prevention project. Nearly 1 million Californians lack safe drinking water, and two-thirds of failing water systems are in low-income, underserved communities. A previous CBCRP-funded drinking water study conducted by UC Davis detected several contaminants in California drinking water linked to breast cancer, such as per and polyfluoroalkyl substances (PFAS), 1,2,3-trichloropropane, and di-ethylhexyl phthalate (DEHP). We plan to build upon the UC Davis drinking water project into underserved communities in the Central Valley and/or Central Coast of California. These regions are disproportionately impacted by groundwater contamination due to their close proximity to agricultural fields, oil extraction sites, landfills, hazardous waste sites, or other industrial areas. Some of the small communities in these regions receive bottled water as a short-term solution. However, this type of solution risks exposure to phthalate compounds and a long-term, affordable and sustainable solution is essential for reducing exposures and improving health and quality of life in these populations. Our proposed Full Award project aims to monitor water contaminants, create culturally relevant educational materials, and develop a community-level intervention that will benefit those impacted by contaminated water and ultimately reduce breast cancer risk. Engaging community members at every stage of the project is imperative to ensure long-term success; thus, during the Planning Grant, we will build relationships with community organizations and members in the regions. For example, the Community Water Center is a community-based organization and is currently engaged in efforts to implement 1,2,3-trichloropropane treatment for domestic wells and small water systems. Once we have developed an understanding of a community’s specific water issues and needs, we will work with CWC, UC Davis, policy makers, health practitioners, and other stakeholders such as Pesticide Action Network and the Safe Ag Safe Schools coalition, to strategize on topics including water monitoring methods, filtration systems as a way to reduce exposure, and community education around taking action on water contamination.
AUT868907_Lay_Abstract – Supplemental material for Understanding anxiety in adults on the autism spectrum: An investigation of its relationship with intolerance of uncertainty, sensory sensitivities and repetitive behaviours
Creators: name: Ye In (Jane) Hwang
name: Arnold, Samuel
name: Preeyaporn Srasuebkul
name: Trollor, Julian
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: Education
subject: 130312 Special Education and Disability
subject: FOS: Educational sciences

description: Supplemental material, AUT868907_Lay_Abstract for Understanding anxiety in adults on the autism spectrum: An investigation of its relationship with intolerance of uncertainty, sensory sensitivities and repetitive behaviours by Ye In (Jane) Hwang, Samuel Arnold, Preeyaporn Srasuebkul and Julian Trollor in Autism
Underground Rising: Reducing breast cancer risks near contaminated coastal sites
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Volatile organic compounds (VOCs) have been left in place in soil and groundwater at former military, industrial and commercial sites. The practice has been to cap these soils at the surface with concrete or clay to keep rain from mobilizing the contaminants. However, in coastal areas the process of rising sea level will push shallow groundwater up at many locations, potentially mobilizing these contaminants from below. Mobilized VOCs can enter indoor air via sewer connections or openings in building foundations and expose people to chemicals associated with increased risk of breast cancer (Miller et al 2020, Kay et al 2024). One study found more than 1,400 sites with contaminants over rising groundwater in the San Francisco Bay Area alone (Hill et al 2023). Most are in underserved areas where people are already exposed to higher levels of pollution. Recent wet winters may have already mobilized contaminants at some sites, since rain can seasonally elevate shallow groundwater by several feet. Groundwater monitoring is absent or very limited, and it is not designed to register maximum levels or check for movement of contaminants offsite. We will use the Full Award to develop a method that would allow government agencies to systematically identify buildings where people are now or may in the near future be at risk of VOC penetration by contaminants associated with increased risk of breast cancer that originate in groundwater. During the Planning Grant, we will pilot our methods on the south Richmond shoreline in the San Francisco Bay Area, where VOCs are known to be present in groundwater and where occupied buildings are connected to sewer lines in the flow path of VOCs. This pilot has three goals: first, to develop a mapping process that identifies sewer lines at risk of VOC infiltration and buildings at risk of indoor air penetration. Second, we will develop a dialogue within our team about methods for sewer and indoor air monitoring in preparation for the Full Proposal. Third, we will develop communication materials to help the public become aware of these risks. Our team has the right mix of expertise to pilot these methods and develop a Full Proposal that could impact how contaminated sites and vulnerable buildings are monitored and managed.
Santa Clara County Breast Cancer Prevention Coalition
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Community Health Partnership of Santa Clara County (CHP) will co-lead a coalition to develop a Full Award CLASP-BC proposal to implement an intervention that advances the primary prevention of breast cancer within some of the most diverse and underserved communities of Santa Clara County, California. CHP’s confirmed coalition partners include Community Agency for Resources, Advocacy and Services, Latinas Contra Cancer, Community in Action Team, Community Solutions, Working Partnerships USA, and the SCC Public Health Department. These organizations represent community, practice, and policy experts. Additionally, the coalition will seek out and secure an academic research partner early in the planning phase. The coalition has identified the following risk factors from the Paths to Prevention: the California Breast Cancer Primary Prevention Plan that the group is most interested in addressing: race, power, and inequities; alcohol; chemicals in consumer products; ionizing radiation; light at night; and occupation. CHP and its partners have extensive experience and expertise in the areas of culturally appropriate health education and promotion, grassroots community organizing, advocacy, and policy campaigns. Therefore, the group expects to implement relevant strategies such as launching public education campaigns, capacity-building for underrepresented groups to increase their involvement in political processes, and influencing regulatory policies and measures that help prevent breast cancer. During the planning grant project period, the coalition will convene periodically to develop the proposal collaboratively and with representative community input. In the first half of the project period, from September to November 2024, the coalition will narrow down its initial ideas, obtain broader community input beyond the project team, and secure a research partner. In the second half of the project period, from December 2024 to February 2025, the coalition will finalize the intervention’s research questions and aims, draft all application components, obtain feedback from the coalition members, and finalize the application package. To ensure all activities are completed on time, CHP will facilitate discussions and decision-making exercises through several in-person meetings.
Additional file 1 of Physical activity practiced at a young age is associated with a less severe subsequent clinical presentation in facioscapulohumeral muscular dystrophy
Creators: name: Bettio, Cinzia
name: Banchelli, Federico
name: Salsi, Valentina
name: Vicini, Roberto
name: Crisafulli, Oscar
name: Ruggiero, Lucia
name: Ricci, Giulia
name: Bucci, Elisabetta
name: Angelini, Corrado
name: Berardinelli, Angela
name: Bonanno, Silvia
name: D’Angelo, Maria Grazia
name: Di Muzio, Antonio
name: Filosto, Massimiliano
name: Frezza, Erica
name: Maggi, Lorenzo
name: Mongini, Tiziana
name: Pegoraro, Elena
name: Rodolico, Carmelo
name: Scarlato, Marina
name: Vattemi, Gaetano
name: Velardo, Daniele
name: Tomelleri, Giuliano
name: D’Amico, Roberto
name: D’Antona, Giuseppe
name: Tupler, Rossella
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Supplemental Table 1
The Breast Cancer Prevention LATCH Plan
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Women who breastfeed lower their risk of breast cancer. Yet only 43% of women in California are still breastfeeding at 12 months because of barriers out of their control. One of the biggest barriers new mothers face is getting quality breastfeeding support after having a baby. This is especially true for Black women, who have a higher chance of dying from breast cancer and getting breast cancer under the age of 40. Getting breastfeeding support is also hard for non-english speakers, low-income families, and other communities that are often not included in health services like LGBTQAI families. The purpose of the Breast Cancer Prevention Lactation Accessibility for Thriving Community Health (LATCH) Plan is to better understand the challenges these communities face when trying to get help, create a comprehensive statewide directory of breastfeeding support services, and provide free breastfeeding phone support in multiple languages. We plan on working with lactation professionals, breastfeeding coalitions, breast cancer experts and the California families most affected by lack of access to breastfeeding support. The information we gather from these advocates, professionals, and parents will help us in creating the most complete breastfeeding support directory in California and the launch of a free breastfeeding phone support helpline. Providing free, easily accessible, multilingual resources and support will help Black, low income, and underrepresented women breastfeed longer, helping prevent breast cancer in these underrepresented populations.
Additional file 2 of Physical activity practiced at a young age is associated with a less severe subsequent clinical presentation in facioscapulohumeral muscular dystrophy
Creators: name: Bettio, Cinzia
name: Banchelli, Federico
name: Salsi, Valentina
name: Vicini, Roberto
name: Crisafulli, Oscar
name: Ruggiero, Lucia
name: Ricci, Giulia
name: Bucci, Elisabetta
name: Angelini, Corrado
name: Berardinelli, Angela
name: Bonanno, Silvia
name: D’Angelo, Maria Grazia
name: Di Muzio, Antonio
name: Filosto, Massimiliano
name: Frezza, Erica
name: Maggi, Lorenzo
name: Mongini, Tiziana
name: Pegoraro, Elena
name: Rodolico, Carmelo
name: Scarlato, Marina
name: Vattemi, Gaetano
name: Velardo, Daniele
name: Tomelleri, Giuliano
name: D’Amico, Roberto
name: D’Antona, Giuseppe
name: Tupler, Rossella
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Supplemental Table 2
Food prices in remote areas of Scotland: A natural experiment measuring the out-shopping effect
Creators: name: Russo, Carlo
name: Revoredo-Giha, Cesar
Publisher: name: Unknown
Year: 2024
Subjects: subject: Consumer/Household Economics
subject: Food Security and Poverty
subject: Remote rural areas
subject: food prices
subject: rural development
subject: consumer behavior
subject: home-scanner data

description: An important aspect of the survival of remote rural areas in a country is whether the food prices that their citizens face are similar to those elsewhere. There is a conflictive literature about existence and magnitude of a “remoteness premium” (i.e., whether households in remote areas pay more for food than the average prices paid in the country). This paper investigates the effect of out-shopping on food expensiveness in remote rural areas in Scotland. For this purpose, a natural experiment was used. An expensiveness index was constructed using home scanner data. Food expensiveness was compared during the 2020 COVID-19 lockdown, when travel restriction prevented out-shopping, with the data from the same period in 2019. It was assumed that the difference – after controlling for the change in the purchased bundle of goods – may be attributed to the lockdown effect, preventing out-shopping. The results find that the premium paid in remote rural areas was small and out-shopping is an important factor limiting food expensiveness in remote areas of Scotland.
Supplemental Material, Appendix_1_Survey_Instrument_(1) - Clinical Pharmacy Practice Patterns Among North Carolina Rural Hospitals
Creators: name: Lanier, Cameron
name: Moss, Jason
name: Tunney, Robert
name: Ruthanne Baird
name: Kelly, Kim
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 111199 Nutrition and Dietetics not elsewhere classified
subject: FOS: Health sciences
subject: 111702 Aged Health Care
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine

description: Supplemental Material, Appendix_1_Survey_Instrument_(1) for Clinical Pharmacy Practice Patterns Among North Carolina Rural Hospitals by Cameron Lanier, Jason Moss, Robert Tunney, Ruthanne Baird and Kim Kelly in Journal of Pharmacy Practice
Os Efeitos Do Vaivém Da Emigração Continental: Um Estudo De Caso Em Melgaço
Creators: name: Castro, Joaquim De
Publisher: name: Zenodo
Year: 2008
Subjects: Emigração, aculturação, diferenciação sociocultural, conflito agonístico, transculturação assimétrica.

description: O objecto de estudo é a emigração melgacense desde meados do século XX e as diferenças socioculturais entre os melgacenses com experiências emigratórias e os residentes, as quais resultam num conflito agonístico entre ambos os grupos. Os melgacenses com percursos emigratórios percepcionam a existência de uma separação sociocultural face aos residentes. A diferenciação sociocultural revela-se no uso da língua estrangeira, na construção da casa “afrancesada” e na ostentação económica, fomentando as tensões agonísticas. No uso da língua estrangeira, os melgacenses com percursos emigratórios sentem-se aculturados e ambivalentes, no entanto, na atribuição para esta situação não se percepcionam como parte interdependente das tensões agonísticas, conferindo relevância a elementos relacionais: o facto de estarem de férias, de reencontrarem a família e a falta de hábito no uso da língua portuguesa. Na problemática da casa “afrancesada”, a socialização laboral realizada é desvalorizada pelos questionados, sendo, no entanto, valoriza pelos informantes privilegiados e, não directamente, pelas profissões mantidas no espaço de acolhimento e pelos graus de escolaridade. A emigração, conquanto conote algo de intrinsecamente negativo, tornou-se num fenómeno social não problematizado. Emigrar, em Melgaço, ainda significa ascender a um estatuto social mais favorável. E, efectivamente, os melgacenses com percursos emigratórios percepcionam-se como tendo ascendido socialmente. Os comportamentos agonísticos dos residentes são percebidos na base da inveja e não como uma redefinição das posições sociais ou através de condições objectivas de ambos os espaços. No registo do conflito agonístico, não se percebem como fonte de tensão agonística, sendo que, no entanto, são os emigrantes, as mulheres, os mais jovens e os licenciados que a percepciona com maior intensidade. Conquanto, a relativa melhoria das condições de vida, em termos comunitários, a ascensão económica parece não ter efeitos positivos, uma vez que a melhoria técnico-profissional é escassa, as remessas têm diminuído, o investimento, agora, é feito no espaço de acolhimento e a desertificação humana e física têm aumentado. A relação mantida entre ambos os espaços, no âmbito da transculturação, é assimétrica.
description: Emigração, aculturação, diferenciação sociocultural, conflito agonístico, transculturação assimétrica.
Additional file 3 of Physical activity practiced at a young age is associated with a less severe subsequent clinical presentation in facioscapulohumeral muscular dystrophy
Creators: name: Bettio, Cinzia
name: Banchelli, Federico
name: Salsi, Valentina
name: Vicini, Roberto
name: Crisafulli, Oscar
name: Ruggiero, Lucia
name: Ricci, Giulia
name: Bucci, Elisabetta
name: Angelini, Corrado
name: Berardinelli, Angela
name: Bonanno, Silvia
name: D’Angelo, Maria Grazia
name: Di Muzio, Antonio
name: Filosto, Massimiliano
name: Frezza, Erica
name: Maggi, Lorenzo
name: Mongini, Tiziana
name: Pegoraro, Elena
name: Rodolico, Carmelo
name: Scarlato, Marina
name: Vattemi, Gaetano
name: Velardo, Daniele
name: Tomelleri, Giuliano
name: D’Amico, Roberto
name: D’Antona, Giuseppe
name: Tupler, Rossella
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Supplementary Fig. 1
O Contexto Da Aculturação Português Através Do Modelo De Rudmin: Do Encontro Intercultural Com O Japão Até Ao Luso-Tropicalismo
Creators: name: Castro, Joaquim De
Publisher: name: Zenodo
Year: 2014
Subjects: Aculturação, luso-tropicalismo, modelo de fusão, modelo de Rudmin, aprendizagem, e/imigração. VI

description: A investigação propôs dois objetivos: explorar e contextualizar a cultura portuguesa da aculturação e deslocar a abordagem da aculturação para a aprendizagem recíproca, tendo em conta o modelo de Rudmin (2009). Aplicou-se o método misto: análise de conteúdo, trabalho quantitativo e etnográfico, mediante uma análise diacrónica e sincrónica, através de fontes primárias e secundárias. A análise de conteúdo às obras de Fernão Mendes Pinto e de Luís de Fróis demonstrou que o discurso histórico português acerca da aculturação reporta aprendizagem recíproca, sendo diferente da cultura anglo-saxónica. Porém, este discurso é também caracterizado pelas relações assimétricas, sendo contradito pela e/imigração portuguesas. Portanto, a tentativa de contextualizar a cultura portuguesa da aculturação foi alargada aos referidos fenómenos. Tornou-se ainda necessário verificar qual a reação da maioria portuguesa às suas mudanças culturais, tendo ainda em conta as apreensões dos emigrantes portugueses e dos imigrantes cabo-verdianos, usando-se três amostras distintas (maioria portuguesa, imigrantes cabo-verdianos e emigrantes portugueses. Assim dispondo, a cultura portuguesa da aculturação foi definida como funcionando através de duas avaliações, simultâneas, uma “ideal”, a qual corresponde ao modelo de fusão e ao luso-tropicalismo, tal como ocorreu na aculturação jesuítica no Japão do século XVI; e uma outra avaliação, a “real”, correspondendo às apreensões desencadeadas pelas motivações das três amostras. A cultura luso-tropical funciona na cultura portuguesa como uma ideologia consensual, preferindo as misturas culturais próprias do modelo da fusão; no entanto, as atitudes culturais mudam consoante o estatuto social das amostras, tornando-as relativas e seletivas, assistindo-se à existência de diferenças inter/intragrupais, sendo que as culturas interagem de forma diferenciada. A cultura portuguesa da aculturação é distinta da anglo-saxónica, levantando a problemática da falta de equivalência e apontando para a necessidade de se contextualizar as investigações provenientes da cultura anglo-saxónica mediante as decisões de utilidade, o background português e a evolução do construto da aculturação. Investigações posteriores deverão abordar a aculturação como um fenómeno interativo e dinâmico, no qual a aprendizagem reciproca é regulada pelas motivações aculturativas; sugeriu-se assim o conceito de saudade, pois este permite verificar as misturas culturais e a manutenção cultural, em simultâneo.

Palavras-Chave: Aculturação, luso-tropicalismo, modelo de fusão, modelo de Rudmin, aprendizagem, e/imigração.

VI
description: Acculturation, Luso-Tropicalism, Fusion Model, Rudmin Model, Learning, E/Immigration.