cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Regulation of low density lipoprotein receptor-related protein gene expression, and, Cholesteryl ester transfer protein-mediated HDL selective uptake in the liver
Creators: name: Gauthier, Andre
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Biology, Molecular.
subject: Chemistry, Biochemistry.

description: Disordered lipoprotein metabolism is a major risk factor for coronary artery disease (CAD). This thesis focuses on two proteins that may exert protective effects against CAD: (1) the regulation of LDL receptor-related protein (LRP) gene expression and (2) hepatic cholesteryl ester transfer protein (CETP)-mediated selective uptake. LRP is a large multifunctional receptor, which is implicated in numerous biologically important processes including lipoprotein metabolism, cell signal transduction and atherosclerosis. Despite this, regulation of LRP gene expression remains largely unknown. We have identified a novel transcriptional regulatory element, known as a peroxisome proliferator response element (PPRE), at position -1185 to -1173 in the 5'-flanking region of the human LRP gene. The PPRE is transactivated by peroxisome proliferator activated receptors (PPAR) alpha and gamma when activated by ligands such as long chain fatty acids, rosiglitazone (PPARgamma-specific) and fenofibric acid (PPARalpha-specific). This results in upregulation of LRP expression and function in several cell types including adipocytes (PPARgamma-expressing) and hepatocytes (PPARalpha-expressing). These data suggest that LRP gene expression could be preferentially modulated by the use of PPAR-selective agonists and may have important implications for the regulation of human preadipocyte differentiation and triglyceride-rich lipoprotein metabolism in adipocytes and hepatocytes. CETP is a hydrophobic glycoprotein that plays a central role in human high-density lipoprotein (HDL) metabolism. We have examined the role of CETP in HDL-cholesteryl ester (CE) selective uptake in primary mouse hepatocytes expressing CETP via adenovirus-mediated gene transfer (ad-CETP) or incubated in CETP-containing media. These studies demonstrate that CETP mediates hepatocyte selective uptake of HDL-derived CE independently of other known lipoprotein receptors. Furthermore, CETP-mediated selective uptake occurs by two pathways, only one of which requires CETP transfer activity. Hepatic expression of ad-CETP in vivo resulted in an acute drop in plasma cholesterol in particles in the HDL density range. Finally, CETP-mediated selective uptake in vivo was only partially inhibited by concomitant administration of torcetrapib, a compound which inhibits CETP neutral lipid transfer activity. Taken together, these studies demonstrate a novel and important role for CETP in the selective uptake of HDL-derived CE by hepatocytes, findings which are of fundamental importance to human lipoprotein metabolism.
Robust estimation of multivariate and spatial autoregression
Creators: name: Roknossadati, Mohammad
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Mathematics.

description: This dissertation consists of five chapters. In Chapter 1, we collect some fundamental concepts and definitions employed in the forthcoming chapters. In Chapter 2, we consider the limiting behavior of a vector autoregressive model of order one (VAR(1)) with independent and identically distributed (i.i.d.) innovations vector with dependent components in the domain of attraction of a multivariate stable law with possibly different indices of stability. It is shown that in some cases the ordinary least squares (OLS) estimates are inconsistent. This inconsistency basically originates from the fact that each coordinate of the partial sum processes of dependent i.i.d. vectors of innovations in the domain of attraction of stable laws needs a different normalizer to converge to a limiting process. It is also revealed that certain M-estimates, with some regularity conditions, as an appropriate alternative, not only resolve inconsistency of the OLS estimates but also give higher consistency rates in all cases. In Chapter 3, we study the limiting behavior of the M-estimators of parameters for a spatial unilateral autoregressive model with i.i.d. innovations in the domain of attraction of a stable law with index alpha ∈ (0, 2]. Both stationary and unit root models and some extensions are considered. It is shown that self-normalized M-estimators are asymptotically normal. In Chapter 4, we investigate the limit theory of the M-estimators of parameters for a near unit root spatial autoregressive model considered in Chapter 3. Finally, some suggestions for future research are presented in Chapter 5.
Flow-Field and Induced Bed Shear Stress Due to a Sphere Oscillating Close to a Boundary
Creators: name: Satish, Samayam
Publisher: name: Swinburne
Year: 2024

description: The study of complex flow field problems concerning fully submerged structures of spherical shape oscillating adjacent to a solid boundary within the fluid is of immense importance due to their fundamental interest and high relevance to wave energy converters. This study investigates the flow field and shear modifications close to a plane boundary using three-dimensional direct numerical simulations and flow visualisation experiments. A novel particle congregation is demonstrated, towards which particles are swept and would accumulate over a long duration of operation of the oscillating object. This phenomenon will affect the positioning of mooring points and seabed environmental impacts.
Combining graphical scenarios with a requirements management system
Creators: name: Jiang, Bo
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Computer Science.

description: Scenarios have gained in popularity for the description of functional requirements. However, scenarios cannot specify all types of requirements, and often they are expressed separately from other requirements. In order for scenarios to be used in cooperation with complementary general requirements, both views must be linked in a way that supports traceability, navigation, and analysis. This thesis proposes an approach to introduce graphical scenarios (represented as Use Case Maps---UCMs) into a requirements management system (namely, Telelogic DOORS) and to maintain relationships from and to external requirements as both views evolve over time. In the first part of the thesis, an export mechanism is added to the Use Case Map Navigator tool that enables the export of UCM models in a format that can be understood by the target requirements management system, i.e., DOORS. In the second part of the thesis, DOORS is enhanced with an import mechanism to create or update UCM models based on the information generated by the UCM tool. Finally, the approach is illustrated with a case study (a supply chain management business process) that demonstrates how the UCM model, the external requirements, and their links can be kept consistent as both views evolve.
Induction of adaptive immunity by a novel influenza vaccine: immunization by mRNA administration
Creators: name: Saad, Amine
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Biology, Microbiology.

description: Vaccination is one of the major strategies available for combating viral infections in humans. The seasonal inactivated influenza virus vaccine elicits type-specific, protective neutralizing antibodies that are detectable in the serum of a vaccinated person; however, the very nature of the virus requires a reformulation of the vaccine to match the currently circulating strains in any given year. In the present study, a novel vaccination approach was developed to induce protective immunity against Influenza A. The approach consisted of delivering naked or protected mRNA encoding for Hemagglutinin as a vaccine. The vaccine was administrated to B6C3Fl mice and the overall immune response raised by an mRNA-based vaccine was assessed through the evaluation of the cellular and humoral responses induced by this type of vaccination and the in vitro protection it confers against Influenza A virus. Results from these studies suggest that rnRNA vaccination in the context of infectious diseases, specifically influenza, is feasible and that mRNA vaccines are capable of inducing a balanced immune response as characterized by the production of protective neutralizing antibodies and the induction of cellular immunity against influenza.
Zircon alteration in wallrock of Pamour and Hoyle Pond Au deposits, Abitibi granite-greenstone belt: Constraints on timescales of fluid flow from depth-profiling techniques
Creators: name: Bachtel, Jonathan M
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Geology.
subject: Petrology.

description: Quartz-carbonate vein Au deposits in the Timmins-Porcupine gold camp, Abitibi Subprovince, have equivocal protracted parageneses and formed during late to post-Kenoran (2750-2670 Ma) deformation and metamorphism. SIMS U-Pb and delta18O depth-profiling and LA-ICPMS REE depth-profiling techniques were employed on unpolished wallrock zircons to resolve temporal constraints on mineralization and hydrothermal fluid sources at Hoyle Pond and Pamour mines. Depth-profiling techniques successfully uncovered <3 mum alteration domains in zircon rims based on Th/U, REE, and isotopic signatures, and rim 207Pb/206Pb ages are significantly younger than host rock ages. Zircon alteration is from a complex interplay of recrystallization and localized dissolution-reprecipitation of metamict to fully crystalline zircon during hydrothermal fluid flow. Alteration of Hoyle Pond and Pamour zircons at 2660 Ma correlates to intensely mineralized and deformed quartz-carbonate-Au shear veins, and this age represents peak fluid infiltration at the mines coinciding with peak regional metamorphism. Subsequent zircon alteration correlating to thin, shallow-dipping and less altered / mineralized vein networks occurred at 2640 Ma, and this age likely represents a late hydrothermal fluid pulse at the end of regional retrograde metamorphism. Protracted hydrothermal alteration along discrete zones within the camp continued into the Proterozoic. Th/U and 18O values of zircon alteration domains suggest that fluids were most likely derived from lower crustal metamorphic and/or plutonic activity. While the underutilized depth-profiling technique has resolved ∼200 m.y. of continuous crustal evolution and fluid flow in the southern Abitibi, further investigation of the southern Abitibi is required to clarify the genetic relationship between Au mineralization and zircon alteration.
Pharmacologic Treatment Assigned for Niemann Pick Type C1 Disease Partly Changes Behavioral Traits in Wild-Type Mice
Creators: name: Schlegel, Victoria
name: Thieme, Markus
name: Holzmann, Carsten
name: Witt, Martin
name: Grittner, Ulrike
name: Rolfs, Arndt
name: Wree, Andreas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: cyclodextrin
subject: allopregnanolone
subject: miglustat
subject: NPC
subject: mice
subject: behavior
subject: accelerod
subject: Morris water maze
subject: elevated plus maze
subject: open field
subject: hot-plate
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Niemann-Pick Type C1 (NPC1) is an autosomal recessive inherited disorder characterized by accumulation of cholesterol and glycosphingolipids. Previously, we demonstrated that BALB/c-npc1nihNpc1−/− mice treated with miglustat, cyclodextrin and allopregnanolone generally performed better than untreated Npc1−/− animals. Unexpectedly, they also seemed to accomplish motor tests better than their sham-treated wild-type littermates. However, combination-treated mutant mice displayed worse cognition performance compared to sham-treated ones. To evaluate effects of these drugs in healthy BALB/c mice, we here analyzed pharmacologic effects on motor and cognitive behavior of wild-type mice. For combination treatment mice were injected with allopregnanolone/cyclodextrin weekly, starting at P7. Miglustat injections were performed daily from P10 till P23. Starting at P23, miglustat was embedded in the chow. Other mice were treated with miglustat only, or sham- treated. The battery of behavioral tests consisted of accelerod, Morris water maze, elevated plus maze, open field and hot-plate tests. Motor capabilities and spontaneous motor behavior were unaltered in both drug-treated groups. Miglustat-treated wild-type mice displayed impaired spatial learning compared to sham- and combination-treated mice. Both combination- and miglustat-treated mice showed enhanced anxiety in the elevated plus maze compared to sham- treated mice. Additionally, combination treatment as well as miglustat alone significantly reduced brain weight, whereas only combination treatment reduced body weight significantly. Our results suggest that allopregnanolone/cyclodextrin ameliorate most side effects of miglustat in wild-type mice. View Full-Text
title: Vías de diseminación metastásica del neuroblastoma
Creators: name: Ballesteros Guerrero, Carmen
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Paediatric

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
Describir las diferentes formas de diseminación del...
Impact of Housing and Community Conditions on Multidimensional Health among Middle- and Low-Income Groups in Hong Kong
Creators: name: Wang, Jionghua
name: Huang, Bo
name: Zhang, Ting
name: Wong, Hung
name: Huang, Yifan
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: With decades of urbanization, housing and community problems (e.g., poor ventilation and lack of open public spaces) have become important social determinants of health that require increasing attention worldwide. Knowledge regarding the link between health and these problems can provide crucial evidence for building healthy communities. However, this link has heretofore not been identified in Hong Kong, and few studies have compared the health impact of housing and community conditions across different income groups. To overcome this gap, we hypothesize that the health impact of housing and community problems may vary across income groups and across health dimensions. We tested these hypotheses using cross-sectional survey data from Hong Kong. Several health outcomes, e.g., chronic diseases and the SF-12 v. 2 mental component summary scores, were correlated with a few types of housing and community problems, while other outcomes, such as the DASS-21–Stress scores, were sensitive to a broader range of problems. The middle- and low-income group was more severely affected by poor built environments. These results can be used to identify significant problems in the local built environment, especially amongst the middle- and low-income group.
A fundamental study of Starling flow and protein redistribution within a cell-free rectilinear membrane flow device.
Creators: name: Pomalis, Richard.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Engineering, Biomedical.

description: The efficiency of hollow fiber bioreactors depends on design and operations parameters. Protein redistribution, a consequence of Starling flow, can result in poor cell distribution and reductions in performance. Hydrodynamic investigations require consideration of design and sampling. A simplified rectilinear flow system was developed and modeled. A 2D (SIMPLER) model incorporating gravity, and correlations for density, viscosity, diffusivities, and osmotic pressures was coded in FORTRAN 77. Experiments with bovine serum albumin (BSA) and a cellulose acetate membrane were carried out to validate the model. Further validation was obtained with a 1D simulator. Simulations show the effects of run duration, initial BSA concentration, channel velocity, and Dextran 70 loading on BSA polarization. The results indicate noticeable BSA polarization only in long duration runs, BSA redistribution in the transverse direction, and the importance of buoyancy. Simulations with fluid flowing against gravity suggest that this orientation can be used to eliminate protein polarization.
Understanding Family Violence Use by Australian Young People: An Examination of Risk and the Impact of Situational Factors
Creators: name: Sheed, Abigail
Publisher: name: Swinburne
Year: 2024

description: This thesis examines the characteristics and behaviour of Australian young people (10 - 24 years; N = 5014) reported to police for using family violence over a four-month period in 2019 (N = 5014). Specifically, it fills a gap in the literature by advancing knowledge of (1) how characteristics vary according to age and offending history, (2) recidivism risk and risk assessment practices, and (3) situational factors relevant to incidents of child-to-parent abuse. The findings of this thesis have several important implications for clinical practice - particularly in the areas of risk assessment, management, and intervention - and theory development.
The SAMI Galaxy Survey: Asymmetry in gas kinematics and its links to stellar mass and star formation
Creators: name: Bloom, J. V.
name: Fogarty, L. M R
name: Croom, S. M.
name: Schaefer, A.
name: Bryant, J. J.
name: Cortese, Luca
name: Richards, S.
name: Bland-Hawthorn, J.
name: Ho, I. T.
name: Scott, N.
name: Goldstein, G.
name: Medling, A.
name: Brough, S.
name: Sweet, Sarah
name: Cecil, G.
name: López-Sánchez, A.
name: Glazebrook, Karl
name: Parker, Q.
name: Allen, J. T.
name: Goodwin, M.
name: Green, A. W.
name: Konstantopoulos, I. S.
name: Lawrence, J. S.
name: Lorente, N.
name: Owers, M. S.
name: Sharp, R.
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 510103
subject: Cosmology and extragalactic astronomy

description: We study the properties of kinematically disturbed galaxies in the Sydney-AAO Multi-object Integral field spectrograph (SAMI) Galaxy Survey using a quantitative criterion, based on kinemetry (Krajnović et al.). The approach, similar to the application of kinemetry by Shapiro et al., uses ionized gas kinematics, probed by Ha emission. By this method, 23 ± 7 per cent of our 360-galaxy sub-sample of the SAMI Galaxy Survey are kinematically asymmetric. Visual classifications agree with our kinemetric results for 90 per cent of asymmetric and 95 per cent of normal galaxies.We find that stellar mass and kinematic asymmetry are inversely correlated and that kinematic asymmetry is both more frequent and stronger in low-mass galaxies. This builds on previous studies that found high fractions of kinematic asymmetry in low-mass galaxies using a variety of different methods. Concentration of star formation and kinematic disturbance are found to be correlated, confirming results found in previous work. This effect is stronger for high-mass galaxies (log(M*) > 10) and indicates that kinematic disturbance is linked to centrally concentrated star formation. Comparison of the inner (within 0.5Re) and outer Ha equivalent widths of asymmetric and normal galaxies shows a small but significant increase in inner equivalent width for asymmetric galaxies.
The NuSTAR view of the non-thermal emission from PSR J0437-4715
Creators: name: Guillot, S.
name: Kaspi, V. M.
name: Archibald, R. F.
name: Bachetti, M.
name: Flynn, Christopher
name: Jankowski, F.
name: Bailes, Matthew
name: Boggs, S.
name: Christensen, F. E.
name: Craig, W. W.
name: Hailey, C. A.
name: Harrison, F. A.
name: Stern, D.
name: Zhang, W. W.
Publisher: name: Swinburne
Year: 2024

description: We present a hard X-ray Nuclear Spectroscopic Telescope Array (NuSTAR) observation of PSR J0437-4715, the nearest millisecond pulsar. The known pulsations at the apparent pulse period ~5.76ms are observed with a significance of 3.7σ, at energies up to 20keV above which the NuSTAR background dominates. We measure a photon index Γ = 1.50 ± 0.25 (90 per cent confidence) for the power-law fit to the non-thermal emission. It had been shown that spectral models with two or three thermal components fit the XMM-Newton spectrum of PSR J0437-4715, depending on the slope of the power-law component, and the amount of absorption of soft X-rays. The new constraint on the high-energy emission provided by NuSTAR removes ambiguities regarding the thermal components of the emission below 3 keV. We performed a simultaneous spectral analysis of the XMM-Newton and NuSTAR data to confirm that three thermal components and a power law are required to fit the 0.3-20 keV emission of PSR J0437-4715. Adding a ROSAT-PSPC spectrum further confirmed this result and allowed us to better constrain the temperatures of the three thermal components. A phase-resolved analysis of the NuSTAR data revealed no significant change in the photon index of the high-energy emission. This NuSTAR observation provides further impetus for future observations with the NICER mission (Neutron Star Interior Composition Explorer) whose sensitivity will provide much stricter constraints on the equation of state of nuclear matter by combining model fits to the pulsar's phase-folded light curve with the pulsar's well-defined mass and distance from radio timing observations.
Dynamical invariants, multistability, controllability and synchronization in delay-differential and difference equations.
Creators: name: Mensour, Boualem.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Biology, Neuroscience.

description: We have studied the properties of nonlinear delay-differential equations (DDE's) that commonly appear in models of physiological, neural control and of laser cavities. These systems exhibit multistability at large delays which makes them attractive for information storage purposes. We have considered the storage in stable periodic orbits of the dynamics of recurrent circuits, involving spiking and non-spiking neurons, and in unstable periodic orbits stabilized by delayed feedback-based chaos-control techniques. The information is encoded into the initial function from which the DDE evolves into a periodic solution. The storage capacity is found to be proportional to the delay time of the feedback loop and to be related to the unstable modes in the linearized system in the absence of control. In the chaotic regime, a combination of stable and unstable modes is used to explain the oscillations in power spectra. The latter is used to estimate the attractor dimension and the metric entropy, which are more simple to calculate than with Lyapunov and dimension techniques, especially when the attractor is high-dimensional. The power spectra also provide analytical insight into multistability of delay-differential and difference equations, an area in which there are still few results. The singular perturbation limit of the DDE provides an improved method to control unstable periodic orbits in discrete-time maps, and in particular, in neural networks that are modeled by discrete-time dynamics. This limit also provides insight into controllability and synchronization of DDE's. This is applied to the context of secure communication, where an information-carrying signal is masked or modulated by a DDE broadband carrier. The results are relevant to the study of control systems, physiological and other, involving multiple feedback loops.
Lean Systems and its Potential Impact on Carbon Intensity
Creators: name: Neser, Sasha
Publisher: name: Swinburne
Year: 2024

description: This research was conducted in response to climate change and the contribution of the manufacturing sector to global warming. It was conducted in collaboration with industry, finding that across multiple industries, carbon emissions can be reduced through the application of lean systems. The research findings are useful for policy makers, academics and manufacturing industry practitioners as it provides evidence that an established operational management framework can be applied by manufacturers to reduce their carbon footprint.
Nucleation kinetics-based solvent selection for the liquid antisolvent crystallization of a lipophilic intermediate
Creators: name: Nandi, Snehashis
name: Padrela, Luis
name: Tajber, Lidia
name: Collas, Alain
Publisher: name: University of Limerick
Year: 2024
Subjects: classificationCode: 34
subject: Chemical sciences
subject: FOS: Chemical sciences

description: The fundamental understanding of solubility and nucleation kinetics are two primary pillars for liquid antisolvent crystallization (LASC) process development. In our present work, the solubility of intermediate A in four different solvents and binary mixtures with water, in the temperature range from 273 K to 323 K, was determined using a liquid chromatographic method to acquire the fundamental thermodynamic information for the LASC process. Intermediate A was monitored both in the solid phase and in the liquid phase by in line Raman spectroscopy. The importance of selection of the optimum scale and mixing conditions (volume and fluid dynamics dependency) for conducting metastable zone width (MSZW) measurements for the nucleation kinetics study, due to stochastic nature of nucleation, has been demonstrated to translate the findings to larger industrial scales. The 3.5 mL volume in reactor with a 3 blade downflow overhead impeller in the Crystalline™ (Technobis) was found to be an optimal platform for the data generation for the extraction of nucleation kinetics. The minimum detection threshold value (fN) reported in the literature was experimentally derived for the intermediate A-solvent systems used, covering the effect of supersaturation, reaction volume and agitation rate. The combined polythermal and antisolvent addition approach was applied to determine MSZWs and, subsequently, the kinetic parameters were estimated based on both linearized integral and 3D nucleation models. It was demonstrated how the derived parameters complemented with accurate solubility data are required to guide solvent selection for bottom-up generation of nanosuspensions. The findings were validated by conducting batch and continuous LASC of intermediate A. Particle size distributions derived from electron scanning microscopy obtained at similar driving forces confirmed the solvents selection order based on their nucleation tendency of dissolved intermediate A. These results serve as an example for applying a nucleation kinetics-based fundamental approach for solvent selection in the development of LASC process for generation of long-acting injectable suspensions.
INTEGRAL EDUCATION: A MEANS FOR SOCIAL TRANSFORMATION
Creators: name: Dhal, Pravat
Publisher: name: figshare
Year: 2020
Subjects: Education

description: Integral education is propounded by the great seer Sri Aurobindo. It aims at transformation of the world through transformation of human consciousness. The psychic is the leader of march among other components physical being, mental being, vital being and spiritual one. It integrates all aspects of human and transforms towards a holistic, integrated, balanced and spiritual being. Individual transformation leads to social and global transformation. How Integral education acts and influences the civilization towards this noble effect is the key of this paper.
The contribution of long-term prisoners to violence in Canadian penitentiaries.
Creators: name: Barlow, Christine.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Sociology, Criminology and Penology.

description: The law pertaining to capital punishment in Canada saw significant changes during the 1960-70 period and culminated in 1976 with the abolishment of capital punishment and its replacement with life sentences for what is known now as first and second degree murder. Individuals incarcerated for these "life sentences" have created a complex managerial dilemma for correctional officials. This study showed that institutions that house long term offenders were indeed disproportionately involved in incidents of violence however it was unclear as to whether that was due to the presence of long term inmates or other factors. This relationship became further in doubt when the second hypothesis revealed that short term not long term inmates were disproportionately involved in incidents of violence and escapes. This finding was consistent with other research done in this area. Finally, a number of distinguishing characteristics were found amongst the long term offender population which might begin to provide a basis for which to predict institutional behavior. Not surprisingly, the distinguishing factors related primarily to age at time of offence and previous convictions and incarcerations. A system of dispersal-concentration appears to most accommodate the findings that the data provides. (Abstract shortened by UMI.)
Expectancies, perceptions and beliefs associated with the generalization of criticism skills over a one year interval.
Creators: name: Welburn, Kenneth.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1989
Subjects: subject: Psychology, Social.

description: This study was designed to assess post-program cognitions and experiences which were hypothesized to play a role in the generalization of social skills over time. In particular, self-efficacy perceptions, outcome expectancies, outcome values, and anxiety were assessed through a Biographical Inventory before participation in a social skills program. The Inventory was then used to assess the subjects' experiences once a month for three months after the program, and one year following the program. Subjects who demonstrated generalization on in-vivo, role-play, or self-report measures of giving and receiving criticism over the one year were contrasted, on their responses to the Biographical Inventory, with those who showed little or no generalization. Results from the in-vivo and self-report measures indicated that the high generalization group differed from the low generalization group in their post-program experiences with giving and receiving criticism. Higher self-efficacy perceptions and the perception of positive consequences were evident for the high generalization group for experiences involving criticism. The results are discussed in relation to self-efficacy theory.
An investigation of mental readiness and its links to performance excellence in surgery.
Creators: name: McDonald, Judy M.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Health Sciences, Education.

description: The purpose of this study was to assess factors that are related to excellence among surgeons. The sample included 33 highly proficient surgeons involved in high- and low-mortality-risk surgery, seven of whom were known by reputation as "elite". A framework developed by researchers in athletics was used to examine how surgeons perform their best in challenging elective procedures. Individual in-depth interviews were carried out to determine their mental readiness before, during and after surgery. This provided a quantitative and qualitative analysis of mental readiness. These findings were compared with Orlick's "Theory of Human Excellence" which is based on results from world-class athletics and other high-performance domains. Common elements of success were found which included: commitment, belief, positive images, mental readiness, full focus, distraction control, and constructive evaluation. Major performance blocks were identified which interfered with optimal performance. Characteristics which distinguished certain groups of surgeons were identified. This investigation confirmed that there were many similarities in mental preparation procedures and perspectives engaged in by top surgeons and top athletes. Practical recommendations for mental training were provided relevant to excellence in the surgical arena.
The SLUGGS Survey: A Catalog of over 4000 Globular Cluster Radial Velocities in 27 Nearby Early-type Galaxies
Creators: name: Forbes, Duncan
name: Alabi, Adebusola
name: Brodie, Jean
name: Romanowsky, Aaron J.
name: Strader, Jay
name: Foster, Caroline
name: Usher, Christopher
name: Spitler, Lee
name: Bellstedt, Sabine
name: Pastorello, Nicola
name: Villaume, Alexa
name: Wasserman, Asher
name: Pota, Vincenzo
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 510103
subject: Cosmology and extragalactic astronomy

description: Here, we present positions and radial velocities for over 4000 globular clusters (GCs) in 27 nearby early-type galaxies from the SLUGGS survey. The SLUGGS survey is designed to be representative of elliptical and lenticular galaxies in the stellar mass range 10 < log M∗/Mo < 11.7. The data have been obtained over many years, mostly using the very stable multi-object spectrograph DEIMOS on the Keck II 10 m telescope. Radial velocities are measured using the calcium triplet lines, with a velocity accuracy of ±10-15 km s-1. We use phase space diagrams (i.e., velocity-position diagrams) to identify contaminants such as foreground stars and background galaxies, and to show that the contribution of GCs from neighboring galaxies is generally insignificant. Likely ultra-compact dwarfs are tabulated separately. We find that the mean velocity of the GC system is close to that of the host galaxy systemic velocity, indicating that the GC system is in overall dynamical equilibrium within the galaxy potential. We also find that the GC system velocity dispersion scales with host galaxy stellar mass, in a similar manner to the Faber-Jackson relation for the stellar velocity dispersion. Publication of these GC radial velocity catalogs should enable further studies in many areas, such as GC system substructure, kinematics, and host galaxy mass measurements.
Survivance de l'art oral traditionnel dans le roman négro-africain d'expression française : "Karim" d'Ousmane Socé, et "Les soleils des indépendances" d'Akmadou Kourouma.
Creators: name: Kasende, Luhaka Anyikoy.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Literature, Romance.

description: L'etude de la survivance de l'art oral traditionnel dans le roman negro-africain d'expression francaise, cas de Karim d'Ousmane Soce et des Soleils des independances d'Ahmadou Kourouma, aborde en trois chapitres les differents aspects importants suggeres implicitement par la formulation meme du sujet de cette these dans une perspective a la fois ethnologique, sociocritique et textuelle. Le premier chapitre, s'appuyant sur des donnees theoriques, circonscrit en la precisant et en l'integrant dans le contexte du milieu traditionnel negro-africain la notion de l'oralite a la fois comme litterature et comme art. Les autres points de ce chapitre determinent les criteres esthetiques et structurels de l'oralite comme art et presentent les deux univers imaginaires des romans choisis dans cette etude comme cadre de production ou de realisation de l'oralite. Le deuxieme chapitre releve des univers romanesques tous les enonces de la litterature orale, en analyse le contexte d'usage et les interprete au niveau syntagmatique selon la logique et les donnees representant les referents extratextuels. Deux tableaux a la fin de ce chapitre explicitent la correspondance entre la thematique de chaque roman et la valeur affirmative de differents enonces de la litterature orale utilises par l'auteur, eclairant ainsi la place de l'oralite dans les romans. Le troisieme chapitre degage des univers des romans les differentes caracteristiques de l'oralite en tant que techniques narratives, etablit le rapport fonctionnel entre ces dernieres et les thematiques ou les theses des romans tout en demontrant que ce choix narratif et structurel participe de la strategie discursive globale des auteurs pour le besoin des theses qu'ils soutiennent.
The medical fee (fee for service) negotiation processes of several Canadian provinces (- to 1978).
Creators: name: Kelly, Albert John.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1982
Subjects: subject: Health Sciences, Health Care Management.

description: The method whereby fees are set for medical services is of significant relevance to the operation and overall total cost of a health care delivery system. Until the advent of medical insurance, the setting of fees was traditionally a matter for the profession. Although many of the early medical insurance organisations were physician sponsored, the profession began to lose its autonomy as these insurance bodies became involved in the process. With the introduction of medicare the setting of fees became a joint government and profession matter with fees, for medical benefit purposes, being set by negotiation. It may be argued that by 1978 the Government had assumed responsibility for medical fee setting in many Provinces. The purpose of this paper is to review the conduct of fee negotiations in five provinces---Alberta (in depth), British Columbia, Saskatchewan, Ontario and Quebec---up until 1978. In the first chapter the purpose is further defined and explained, while in the second the method to be followed is developed. The third chapter is devoted to a review of literature relevant to physician behaviour in relation to fees and income. As an introduction to the chapters dealing with the individual Provinces the fourth chapter develops a set of possible objectives for the profession and the government in the fee negotiation process; this reference set is provided to allow the reader to access the conduct of negotiations in each Province. The individual provinces are dealt with one by one in Chapters V to IX. In the final chapter the conduct of fee negotiations is discussed.
The physical properties of cupric nitrosyl complexes.
Creators: name: Mercer, Mary.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1962
Subjects: subject: Chemistry, Organic.

description: The reaction between cupric chloride and nitric oxide in methanol has been studied by measuring the absorption of nitric oxide per mole copper as a function of initial cupric chloride concentration. The results were interpreted by the equilibria: CuCl2+NO&rlhar2;CuCl2NO CuCl2NO&rlhar2;CuCl2- +NO+ NO++CH3OH&rlhar2;CH3 NO2+H+ Over the concentration range 0.016--0.2 M, dissociation of the nitrosyl to NO-containing species is estimated to be 35%. As the concentration is decreased further, this dissociation tends to completion. The nitrosyl of salicylal o-hydroxybenzylamine copper (II) was prepared, and the number of molecules of associated solvent determined by the mole ratio method.* The nitrosyl complexes of cupric iodide, cyanide, thiocyanate and pyridine thiocyanate have been prepared in solution. The nitrosyls of cupric iodide, cyanide and thiocyanate are extremely unstable, with a lifetime of the order of two minutes. The nitrosyl of cupric pyridine thiocyanate is stable in solution for several hours. Spectrophotometric evidence is presented for their existence. Further investigations covered cupric nitrate, hydroxide, iodate, aslicyaldoximate and dithio-oxamide. None of these compounds were observed to form nitrosyls. Consideration of the conditions under which nitrosyls may be formed has led to the suggestion that NO requires to be able to attack the fourth co-planar position. The solid nitrosyls of cupric bromide and chloride have been isolated by precipitation with petroleum ether. On drying, the solid loses associated solvent, and it is suggested that dimerization could be expected to (CuCl 2NO)2. Analysis of the solid shows that it may be isolated with one molecule of solvent attached. Solvation determination by I.R. spectra on CuCl2NO shows that one molecule of solvent is attached, with some indication of a second less strongly held. *Please refer to dissertation for diagrams.
The structure of smoking motivation: The development and initial validation of a smoking motives inventory.
Creators: name: Forrester, Leslie Anne.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Psychology, Behavioral.

description: There has been increasing pressure on all health-related disciplines, including epidemiology to translate research findings into practice. As a result, the need for valid and reliable data has become increasingly important. The primary objective of the present investigation was to develop a clinically relevant and psychometrically sound measure of motivation for the maintenance of smoking behaviour. A balance of clinimetric and psychometric strategies for scale development was employed. Based on a sample of 200 regular daily smokers, the present study revealed that there are three prominent and important factors that motivate smokers to maintain their smoking behaviour. Specifically, our data demonstrated that regular daily smokers are motivated to maintain their smoking behaviour to reduce or eliminate negative emotions, to satisfy their addiction to cigarettes and to obtain pleasure and relaxation. The literature, however, has identified at least seven factors that motivate smokers to maintain their smoking behaviour. Explanations for the discrepancy in the number of smoking motive factors observed are forwarded. Preliminary psychometric evaluation of the Smoking Motives Inventory and two of its subscales, namely Reduction in Negative Affect and Addiction, indicate strong support for the internal consistency reliability of the scale and initial support for its validity, Further work is required to develop the Pleasure and Relaxation factor. Finally, the implications of the findings and directions for future research are presented.
Autophagy has a key role in the pathophysiology of schizophrenia
Creators: name: Merenlender-Wagner, A.
name: Malishkevich, A.
name: Shemer, Z.
name: Udawela, M.
name: Gibbons, A.
name: Scarr, E.
name: Dean, Brian
name: Levine, J.
name: Agam, G.
name: Gozes, I.
Publisher: name: Swinburne
Year: 2024

description: Autophagy is a process preserving the balance between synthesis, degradation and recycling of cellular components and is therefore essential for neuronal survival and function. Several key proteins govern the autophagy pathway including beclin1 and microtubule associated protein 1 light chain 3 (LC3). Here, we show a brain-specific reduction in beclin1 expression in postmortem hippocampus of schizophrenia patients, not detected in peripheral lymphocytes. This is in contrast with activity-dependent neuroprotective protein (ADNP) and ADNP2, which we have previously found to be deregulated in postmortem hippocampal samples from schizophrenia patients, but that now showed a significantly increased expression in lymphocytes from related patients, similar to increases in the anti-apoptotic, beclin1-interacting, Bcl2. The increase in ADNP was associated with the initial stages of the disease, possibly reflecting a compensatory effect. The increase in ADNP2 might be a consequence of neuroleptic treatment, as seen in rats subjected to clozapine treatment. ADNP haploinsufficiency in mice, which results in age-related neuronal death, cognitive and social dysfunction, exhibited reduced hippocampal beclin1 and increased Bcl2 expression (mimicking schizophrenia and normal human aging). At the protein level, ADNP co-immunoprecipitated with LC3B suggesting a direct association with the autophagy process and paving the path to novel targets for drug design.
Mineral potential modelling of gold and silver mineralization in the Nevada Great Basin: A GIS-based analysis using weights of evidence.
Creators: name: Mihalasky, Mark John.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Physical Geography.

description: The distribution of 2,690 gold-silver-bearing occurrences in the Nevada Great Basin was examined in terms of spatial association with various geological phenomena. Analysis of these relationships, using GIS and weights of evidence modelling techniques, has predicted areas of high potential where little or no mining activity exists. Mineral potential maps for sedimentary ("disseminated") and volcanic ("epithermal") rock-hosted gold-silver mineralization revealed two distinct patterns that highlight two sets of crustal-scale geologic features that likely control the regional distribution of these deposit types. Mineral potential maps predicting the distribution of gold-silver-bearing occurrences successfully predicted nearly 70% of the total number of known occurrences. In blind tests, the sedimentary and volcanic rock-hosted mineral potential maps predicted 10 out of 12 and 5 out of 5 occurrences, respectively. The key mineral predictor factors, in order of importance, were determined to be: geology (including lithology, structure, and lithotectonic terrane), geochemistry (indication alteration), and geophysics. Areas of elevated sedimentary rock-hosted mineral potential are generally confined to central, north-central, and north-eastern Nevada. These areas form a conspicuous "V"-shape pattern that is coincident with the Battle Mountain-Eureka (Cortez) and Carlin mineral trends and a segment of the Roberts Mountain thrust front, which bridges the southern ends of the trends. This pattern appears to delineate northwest-southeast-trending crustal-scale structural zones, here termed the "Carlin" and "Cortez" structural zones. Mineralizing processes were focused along these structural zones. The Carlin and Cortez structural zones are considered to be transcurrent features representing a long-lived, deep-crustal or mantle-rooted zone of weakness. Areas of elevated volcanic rock-hosted mineral potential are principally distributed along two broad and diffuse belts that trend (1) northwest-southeast across Nevada, parallel to the Sierra Nevada, and (2) northeast-southwest across northern Nevada, extending diagonally from the Sierra Nevada to southern Idaho. The first belt corresponds to the Walker Lane shear zone, a wide region of complex strike-slip faulting. The second, here termed the " Humboldt shear(?) zone", may represent a structural zone of transcurrent movement. Volcanic rock-hosted mineralizing was closely tied to the southward and westward migration of Tertiary magmatism across the region (which may have been mantle plume-driven). Latest movement along the Humboldt shear(?) zone is constrained between ∼42-30 Ma (sedimentary rock-hosted mineralization) and ∼17-14 Ma, (most recent igneous activity along the northern Nevada rift zone). (Abstract shortened by UMI.)