Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer
Creators: name: Beckmann, Lars
name: Khaw, Kay-Tee
name: Robson, Mark
name: Lambrechts, Diether
name: Lilyquist, Janna
name: Hallberg, Emily
name: Winqvist, Robert
name: Richardson, Andrea
name: Mulligan, Anna M.
name: Tung, Nadine
name: Arver, Brita
name: Scott, Rodney
name: Arun, Banu K.
name: Glendon, Gord
name: Zheng, Wei
name: Nevanlinna, Heli
name: Malone, Kathleen E.
name: Milne, Roger L.
name: Greene, Mark H.
name: Chung, Wendy K.
name: Neuhausen, Susan L.
name: Makalic, Enes
name: Le Marchand, Loic
name: Tollenaar, Robert A. E. M.
name: Benitez, Javier
name: Beckmann, Matthias W.
name: Santella, Regina M.
name: Tamimi, Rulla
name: Ekici, Arif B.
name: Hall, Per
name: Ahsan, Habibul
name: Olson, Janet E.
name: Jensen, Uffe Birk
name: Barrowdale, Daniel
name: Ghoussaini, Maya
name: Lindblom, Annika
name: Montagna, Marco
name: Kabisch, Maria
name: Cox, Angela
name: Gabrielson, Marike
name: Kraft, Peter
name: Radice, Paolo
name: Tihomirova, Laima
name: Wang-Gohrke, Shan
name: Szabo, Csilla I.
name: Claes, Kathleen B. M.
name: Hooning, Maartje J.
name: Buys, Saundra S.
name: Lindstrom, Sara
name: Tumino, Rosario
name: Lee, Eunjung
name: Swerdlow, Anthony
name: Eccles, Diana M.
name: Rahman, Nazneen
name: Bonanni, Bernardo
name: Darabi, Hatef
name: Nathanson, Katherine L.
name: Barile, Monica
name: Hansen, Thomas V. O.
name: Chenevix-Trench, Georgia
name: Mai, Phuong L.
name: Cross, Simon S.
name: Jones, Michael
name: Teo, Soo-Hwang
name: Carpenter, Jane
name: Dos-Santos-Silva, Isabel
name: Wang, Zhaoming
name: Peto, Julian
name: Tsimiklis, Helen
name: Dorfling, Cecilia M.
name: Schmidt, Marjanka K.
name: Cunningham, Julie M.
name: Rappaport, Christine
name: Gapstur, Susan M.
name: Schmutzler, Rita K.
name: Haeberle, Lothar
name: Guénel, Pascal
name: Goldberg, Mark S.
name: Hunter, David J.
name: Karlan, Beth Y.
name: Olopade, Olufunmilayo I.
name: Lester, Jenny
name: Stoppa-Lyonnet, Dominique
name: Czene, Kamila
name: Turnbull, Clare
name: Haiman, Christopher A.
name: Andrulis, Irene L.
name: Miller, Austin
name: Bogdanova, Natalia V.
name: Toland, Amanda E.
name: Park, Sue K.
name: Senter, Leigha
name: Ehrencrona, Hans
name: Dunning, Alison M.
name: Van Rensburg, Elizabeth J.
name: Couch, Fergus J.
name: Giles, Graham G.
name: Kwong, Ava
name: Yang, Xiaohong R.
name: Olswold, Curtis
name: Lubinski, Jan
name: Barkardottir, Rosa B.
name: Flesch-Janys, Dieter
name: Nordestgaard, Børge G.
name: Domchek, Susan M.
name: Mendoza-Fandino, Gustavo A.
name: Bojesen, Stig E.
name: Easton, Douglas F.
name: Yao, Song
name: Teulé, Alex
name: Sinilnikova, Olga M.
name: Slager, Susan
name: Zamora, M Pilar
name: Schmidt, Daniel F.
name: Vachon, Celine
name: Hamann, Ute
name: Ko, Yon-Dschun
name: Gerdes, Anne-Marie
name: Nussbaum, Robert L.
name: Devilee, Peter
name: Southey, Melissa
name: Rennert, Gad
name: Eliassen, Heather
name: Humphreys, Keith
name: García-Closas, Montserrat
name: Chang-Claude, Jenny
name: Healey, Sue
name: Lindor, Noralane
name: Godwin, Andrew K.
name: Soucy, Penny
name: Huzarski, Tomasz
name: Figueroa, Jonine
name: Teixeira, Manuel R.
name: Thompson, Deborah
name: Sawyer, Elinor J.
name: Hopper, John L.
name: Mazoyer, Sylvie
name: Goldgar, David E.
name: Mannermaa, Arto
name: Ursin, Giski
name: Diez, Orland
name: Agata, Simona
name: Long, Jirong
name: Knight, Julia A.
name: Dolcetti, Riccardo
name: Hogervorst, Frans B. L.
name: Van Deurzen, Carolien H. M.
name: Hollestelle, Antoinette
name: Rutgers, Emiel J.
name: Ganz, Patricia A.
name: Antoniou, Antonis C.
name: Fasching, Peter A.
name: Hoover, Robert N.
name: Friebel, Tara
name: Weitzel, Jeffrey N.
name: Peterlongo, Paolo
name: Chanock, Stephen J.
name: Monteiro, Alvaro A. N.
name: Damiola, Francesca
name: Weiderpass, Elisabete
name: Tapper, William
name: Phelan, Catherine M.
name: Hart, Steven
name: Friedman, Eitan
name: Anton-Culver, Hoda
name: Blank, Stephanie V.
name: Margolin, Sara
name: Burwinkel, Barbara
name: Sanchez, Maria-Jose
name: Kuchenbaecker, Karoline B.
name: Tomlinson, Ian
name: Liu, Jianjun
name: González-Neira, Anna
name: Rudolph, Anja
name: Varon-Mateeva, Raymonda
name: Pylkäs, Katri
name: Canzian, Federico
name: Miron, Penelope
name: Arndt, Volker
name: Wildiers, Hans
name: Fostira, Florentia
name: Peissel, Bernard
name: Caldes, Trinidad
name: Rantala, Johanna
name: Ellis, Steve
name: Michailidou, Kyriaki
name: Garber, Judy
name: Konstantopoulou, Irene
name: Kibriya, Muhammad G.
name: Heikkinen, Tuomas
name: Aittomäki, Kristiina
name: Laitman, Yael
name: Kar, Siddhartha
name: Truong, Thérèse
name: Sharma, Priyanka
name: Thomassen, Mads
name: Försti, Asta
name: Gaudet, Mia M.
name: Bolla, Manjeet K.
name: Olah, Edith
name: Janavicius, Ramunas
name: Gunter, Marc
name: Ambrosone, Christine
name: Yannoukakos, Drakoulis
name: Lazaro, Conxi
name: Frost, Debra
name: Brenner, Hermann
name: Terry, Mary B.
name: Caligo, Maria A.
name: Steinemann, Doris
name: Marme, Frederik
name: Osorio, Ana
name: James, Paul
name: De La Hoya, Miguel
name: Pharoah, Paul D. P.
name: Meindl, Alfons
name: Blomqvist, Carl
name: Pilarski, Robert
name: Dumont, Martine
name: Kosma, Veli-Matti
name: Romieu, Isabelle
name: Khan, Sofia
name: Henderson, Brian E.
name: Peeters, Petra H.
name: Singer, Christian F.
name: Kristensen, Vessela
name: Gronwald, Jacek
name: Simard, Jacques
name: Martens, John W. M.
name: Mcguffog, Lesley
name: Gayther, Simon A.
name: Imyanitov, Evgeny N.
name: John, Esther M.
name: Offit, Kenneth
name: Schumacher, Fredrick
name: Gammon, Marilie D.
name: Stenmark-Askmalm, Marie
name: Foulkes, William D.
name: Isaacs, Claudine
name: Whittemore, Alice
name: Nord, Silje
name: Daly, Mary B.
name: Ding, Yuan C.
name: Manoukian, Siranoush
name: Jakubowska, Anna
name: Muranen, Taru A.
name: Herzog, Josef
name: Poppe, Bruce
name: Brauch, Hiltrud
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P<5 × 10−8) with oestrogen receptor (ER)-negative breast cancer and BRCA1-associated breast cancer risk. In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negative cases and 14,352 controls, combined with 7,333 ER-negative cases and 42,468 controls and 15,252 BRCA1 mutation carriers genotyped on the iCOGS array. We identify four previously unidentified loci including two loci at 13q22 near KLF5, a 2p23.2 locus near WDR43 and a 2q33 locus near PPIL3 that display genome-wide significant associations with ER-negative breast cancer. In addition, 19 known breast cancer risk loci have genome-wide significant associations and 40 had moderate associations (P<0.05) with ER-negative disease. Using functional and eQTL studies we implicate TRMT61B and WDR43 at 2p23.2 and PPIL3 at 2q33 in ER-negative breast cancer aetiology. All ER-negative loci combined account for ∼11% of familial relative risk for ER-negative disease and may contribute to improved ER-negative and BRCA1 breast cancer risk prediction.