cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
In vitro and in vivo elucidation of AMPK as a new therapeutic target in Amyotrophic Lateral Sclerosis
Creators: name: Coughlan, Karen
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Adenosine 5'-monophosphate-activated protein kinase (AMPK) is the main sensor and regulator of energy homeostasis in the body. As abnormal energy metabolism is a well documented pathological feature of Amyotrophic Lateral Sclerosis (ALS) in patients and mouse models of ALS, we investigated AMPK as a possible therapeutic target to relieve disease phenotype in ALS mice. Firstly, we examined AMPK signalling patterns across disease progression in SOD1G93a mice, as this mouse model is the most characterised and well understood mouse model of ALS. We observed increased AMPK activation in S0D1G93A spinal cords at symptom onset (post natal day (PND) 90) which also continued later into disease progression at PND 120. As AMPK can activate autophagy we investigated autophagy protein levels also. Similarly, we found elevated autophagy activity at PND 90. Latrepirdine has recently been identified as a small molecular activator of AMPK. Therefore, we tested the effect of Latrepirdine treatment in primary motor neuron cells and found that it elevated AMPK activation when used at a sub-nanomolar concentration (0.1 nM). Additionally, in vivo, Latrepirdine treatment increased AMPK activation in spinal cords of S0D1G93A and TDP-43A3I5T mice when used at 1 pg/kg dose. Furthermore, previous studies targeting AMPK in pre-conditioning treatment paradigms have proved to be neuroprotective. Transient AMPK activation is associated with pro-survival effects, while pro-longed AMPK activation can lead to cell death. Flere, we trialled Latrepirdine as a possible therapeutic agent in SOD 1G93A mice (n=24 animals per group; sex- and litter-matched), and found that ‘pre-conditioning’ treatment with Latrepirdine (1 pg/kg, i.p.) from PND 70 - PND 120 improved survival (p<0.01) and delayed the onset of motor function disabilities in these mice, particularly in males. Moreover, we characterised AMPK signalling in another mouse model of ALS, TDP-43A315T mice. We investigated AMPK as a pharmalogical target in this mouse model using Latrepirdine as a ‘pre-conditioning’ treatment (1 pg/kg, i.p.) from PND 40 - PND 80 and found that this treatment regime increased lifespan significantly (p<0.05) also. The work from this thesis shows that ‘pre-conditioning’ treatments using Latrepirdine may provide a possible therapeutic strategy to target AMPK in ALS. Additionally, as Latrepirdine significantly increased life span in two mouse models of ALS, this pharmalogical treatment strategy may be a possible therapeutic intervention in many sub-populations of ALS cases linked to various genetic mutations of the disease.
Dual polarization nonlinear Fourier transform-based optical communication system
Creators: name: Gaiarin, Simone
name: Perego, Auro Michele
name: da Silva, Edson Porto
name: Da Ros, Francesco
name: Zibar, Darko
Publisher: name: arXiv
Year: 2018
Subjects: subject: Emerging Technologies (cs.ET)
subject: FOS: Computer and information sciences

description: New services and applications are causing an exponential increase in internet traffic. In a few years, current fiber optic communication system infrastructure will not be able to meet this demand because fiber nonlinearity dramatically limits the information transmission rate. Eigenvalue communication could potentially overcome these limitations. It relies on a mathematical technique called "nonlinear Fourier transform (NFT)" to exploit the "hidden" linearity of the nonlinear Schrödinger equation as the master model for signal propagation in an optical fiber. We present here the theoretical tools describing the NFT for the Manakov system and report on experimental transmission results for dual polarization in fiber optic eigenvalue communications. A transmission of up to 373.5 km with bit error rate less than the hard-decision forward error correction threshold has been achieved. Our results demonstrate that dual-polarization NFT can work in practice and enable an increased spectral efficiency in NFT-based communication systems, which are currently based on single polarization channels.
Additional file 1: of Biological compatibility between two temperate lineages of brown dog ticks, Rhipicephalus sanguineus (sensu lato)
Creators: name: Dantas-Torres, Filipe
name: Latrofa, Maria
name: Ramos, Rafael
name: Lia, Riccardo
name: Capelli, Gioia
name: Parisi, Antonio
name: Porretta, Daniele
name: Urbanelli, Sandra
name: Otranto, Domenico
Publisher: name: figshare
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Science Policy

description: Table S1. Group, stage, generation and genotype of ticks genetically identified in this study. (DOCX 18 kb)
The Perturbative Onset of Multiparticle Production in Weak Interactions
Creators: name: Morris, D. A.
name: Rosenfeld, R.
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We use perturbation theory to estimate the energy scale beyond which multiparticle final states become a dominant feature of high energy weak interactions. Using estimates from a weak parton model and comparing two, three and four body final states we deduce that multiparticle states become important at energy scales in the range 10**7 - 10**9 GeV.
description: 23 pages, 10 figures (in PostScript, available on request), typeset in LaTeX, UCLA 92/TEP/38
title: ADCO, Cinquième cartulaire de Saint-Étienne de Dijon (1664), Cart. 28 (G 132), 258 folios, f. 00239
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cinquième cartulaire de Saint-Étienne de Dijon (1664), Archives départementales de la Côte-d'Or, Cart. 28 (G 132), 258 folios, f. 00239, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cinquième cartulaire de Saint-Étienne de Dijon (1664), Archives départementales de la Côte-d'Or, Cart. 28 (G 132), 258 folios, f. 00239, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
A Radio Frequency Non-reciprocal Network Based on Switched Acoustic Delay Lines
Creators: name: Lu, Ruochen
name: Manzaneque, Tomas
name: Yang, Yansong
name: Gao, Liuqing
name: Gao, Anming
name: Gong, Songbin
Publisher: name: arXiv
Year: 2018
Subjects: subject: Signal Processing (eess.SP)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: This work demonstrates the first non-reciprocal network based on switched low-loss acoustic delay lines. The 4-port circulator is built upon a recently reported frequency-independent, programmable, non-reciprocal framework based on switched delay lines. The design space for such a system, including the origins of the insertion loss and harmonic responses, is theoretically investigated, illustrating that the key to better performance and low-cost modulation signal synthesis lies in a large delay. To implement a large delay, we resort to in-house fabricated low-loss, wide-band lithium niobate (LiNbO3) SH0 mode acoustic delay lines employing single-phase unidirectional transducers (SPUDT). The 4-port circulator, consisting of two switch modules and one delay line module, has been modularly designed, assembled, and tested. The design process employs time-domain full circuit simulation and the results match well with measurements. A 18.8 dB non-reciprocal contrast between insertion loss (IL = 6.6 dB) and isolation (25.4 dB) has been achieved over a fractional bandwidth of 8.8% at a center frequency 155 MHz, using a record low switching frequency of 877.19 kHz. The circulator also shows 25.9 dB suppression for the intra-modulated tone and 30 dBm for IIP3. Upon further development, such a system can potentially lead to future wide-band, low-loss chip-scale nonreciprocal RF systems with unprecedented programmability.
description: 13 pages, 23 figures
Relativistic Dynamical Friction in the Weak Scattering Limit
Creators: name: Syer, D.
Publisher: name: arXiv
Year: 1994
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: A test mass, $M$, moving through an ambient medium of light particles with lower average kinetic energy than itself suffers a deceleration caused by its scattering of the light particles. The phenomenon is usually referred to as dynamical friction. The velocity, $\v$, of the test mass decays on a timescale independent of $\v$ in the non-relativistic case. We derive expressions for dynamical friction in the case that the test mass and the light particles are relativistic, and that the scattering is weak (with impact parameter, $b\gg M$). In the case that the light particles are ultra-relativistic, and isotropic in the frame in which $M$ moves with velocity $v$, we find an explicit expression for the dynamical friction. The well known factor of 2 correcting the Newtonian scattering of photons to give the Einstein angle, $4M/b$, has the largest effect on the resulting friction, which is modified by a factor of roughly $16 / 3γ_v$ over the simple non-relativistic case. In the non-relativistic case, the largest contribution to the friction comes from light particles moving slower than $v$. We find that this is not the case for ultra-relativistic scattering, essentially because the scattering angle is independent of $\v$. Some astrophysical implications are discussed. (Accepted for publication in Monthly Notices.)
description: 10 pages (no figures), self-unpacking uuencoded PostScript (uufiles), RDF#1
Additional file 1 of Isopsoralen ameliorates rheumatoid arthritis by targeting MIF
Creators: name: Han, Yi
name: Wang, Jinguang
name: Li, Shufeng
name: Li, Yi
name: Zhang, Yongli
name: Zhang, Ruojia
name: Zhang, Yuang
name: Fan, Huancai
name: Shi, Haojun
name: Pan, Jihong
name: Song, Guanhua
name: Ge, Luna
name: Wang, Lin
Publisher: name: figshare
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1: Figure S1.
Is molecular cloud turbulence driven by external supernova explosions?
Creators: name: Seifried, D.
name: Walch, S.
name: Haid, S.
name: Girichidis, P.
name: Naab, T.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present high-resolution ($\sim$ 0.1 pc), hydrodynamical and magnetohydrodynamical simulations to investigate whether the observed level of molecular cloud (MC) turbulence can be generated and maintained by external supernova (SN) explosions. The MCs are formed self-consistently within their large-scale galactic environment following the non-equilibrium formation of H$_2$ and CO including (self-) shielding and important heating and cooling processes. The MCs inherit their initial level of turbulence from the diffuse ISM, where turbulence is injected by SN explosions. However, by systematically exploring the effect of individual SNe going off outside the clouds, we show that at later stages the importance of SN driven turbulence is decreased significantly. This holds for different MC masses as well as MCs with and without magnetic fields. The SN impact also decreases rapidly with larger distances. Nearby SNe ($d$ $\sim$ 25 pc) boost the turbulent velocity dispersions of the MC by up to 70 per cent (up to a few km s$^{-1}$). For $d$ $>$ 50 pc, however, their impact decreases fast with increasing $d$ and is almost negligible. For all probed distances the gain in velocity dispersion decays rapidly within a few 100 kyr. This is significantly shorter than the average timescale for a MC to be hit by a nearby SN under solar neighbourhood conditions ($\sim$ 2 Myr). Hence, at these conditions SNe are not able to sustain the observed level of MC turbulence. However, in environments with high gas surface densities and SN rates like the Central Molecular Zone, observed elevated MC dispersions could be triggered by external SNe.
description: 10 pages, 11 figures, accepted for publication in ApJ, updated to final version
The Quantum Hall Effect in a One-Dimensional Lateral Superlattice: Nearly Dissipationless Transport Across High Potential Barriers
Creators: name: Müller, G.
name: Weiss, Dieter
name: Klitzing, K.
name: Streda, P.
name: Weimann, G.
Publisher: name: Universität Regensburg
Year: 1995
Subjects: subject: 530 Physik

description: We have investigated strongly modulated one- dimensional lateral superlattices in the quantum Hall regime. Although the modulation amplitude is comparable to the Fermi energy in the system, giving rise to zero magnetic field square resistances of up to 75 k¦¸, we observe nearly dissipationless transport across the barriers at integer filling factors. While the Hall resistance displays quantized plateaus, there are no gaps in the Landau level density of states. The experimental findings can be explained in terms of B¨¹ttiker¡¯s edge channel model involving the high aspect ratio of the barriers.
SPH/N-body simulations of small (D = 10 km) asteroidal breakups and improved parametric relations for Monte-Carlo collisional models
Creators: name: Ševeček, P.
name: Brož, M.
name: Nesvorný, D.
name: Enke, B.
name: Durda, D.
name: Walsh, K.
name: Richardson, D. C.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We report on our study of asteroidal breakups, i.e. fragmentations of targets, subsequent gravitational reaccumulation and formation of small asteroid families. We focused on parent bodies with diameters $D_{\rm pb} = 10$ km. Simulations were performed with a smoothed-particle hydrodynamics (SPH) code combined with an efficient N-body integrator. We assumed various projectile sizes, impact velocities and impact angles (125 runs in total). Resulting size-frequency distributions are significantly different from scaled-down simulations with $D_{\rm pb} = 100$ km targets (Durda et al., 2007). We derive new parametric relations describing fragment distributions, suitable for Monte-Carlo collisional models. We also characterize velocity fields and angular distributions of fragments, which can be used as initial conditions for N-body simulations of small asteroid families. Finally, we discuss a number of uncertainties related to SPH simulations.
description: Accepted to Icarus
Multi-Channel Selective Femtosecond Coherent Control Based on Symmetry Properties
Creators: name: Gandman, Andrey
name: Chuntonov, Lev
name: Rybak, Leonid
name: Amitay, Zohar
Publisher: name: arXiv
Year: 2007
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We present and implement a new scheme for extended multi-channel selective femtosecond coherent control based on symmetry properties of the excitation channels. Here, an atomic non-resonant two-photon absorption channel is coherently incorporated in a resonance-mediated (2+1) three-photon absorption channel. By proper pulse shaping, utilizing the invariance of the two-photon absorption to specific phase transformations of the pulse, the three-photon absorption is tuned independently over order-of-magnitude yield range for any possible two-photon absorption yield. Noticeable is a set of two-photon dark pulses inducing widely-tunable three-photon absorption.
Additional file 2: of Community knowledge, attitudes and practices related to schistosomiasis and associated healthcare-seeking behaviours in northern Côte d’Ivoire and southern Mauritania
Creators: name: Amoin Koffi
name: Doumbia, Mohamed
name: Fokou, Gilbert
name: Keita, Moussa
name: Brama Koné
name: N’doumy Abé
Publisher: name: figshare
Year: 2018
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: Plant Biology

description: Table S1. Sociodemographic characteristics of informants. (DOC 58 kb)
L’occhio di Quasimodo
Creators: name: Paino, Marina
Publisher: name: Avellino : Associazione culturale Internazionale Sinestesie
Year: 2019
Subjects: Quasimodo
Letteratura
Arti visive
Cromatismo
Literature
Visual arts
Chromatism

description: Figlio di una generazione intellettuale che ha variamente cercato e coltivato feconde contaminazioni testuali (spesso rinsaldate da rapporti amicali) tra la letteratura e le arti visive, Salvatore Quasimodo non ha mancato di intrecciare la propria poesia e la propria attività di uomo di cultura con l’espressione figurativa, nella scia di un’esperienza ampiamente praticata da tanti in quel periodo e tra essi da quell’Elio Vittorini.
description: Son of an intellectual generation which has variously searched for and cultivated productive textual contaminations (usually reiforced by friendly relations) between literature and visual arts, Salvatore Quasimodo interwined his own poetry and cultural activity with the figurative arts, as many others did at time (and Elio Vittorini was one of them).
Chemical Principles of Topological Semimetals
Creators: name: Schoop, Leslie
name: Pielnhofer, Florian
name: Lotsch, Bettina
Publisher: name: arXiv
Year: 2018
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Initiated by the discovery of topological insulators, topologically non-trivial materials have attracted immense interest in the physics community in the past decade. One of the latest additions to the field, the material class of topological semimetals, has grown at an extremely fast rate . While the prototype of a topological semimetal, graphene, has been known for a while, the first 3D analogues of graphene have only been discovered recently. This review, written from a chemistry perspective, intends to make the growing field of topological semimetals accessible to the wider community of materials scientists and scholars from related disciplines. To this end, we describe key features of topological semimetals, embedded in their electronic structure, and how they can be achieved based on chemical principles. We introduce the different classes of topological semimetals and review their salient representatives. Finally, selected properties and potential applications of these materials are discussed.
description: published in Chem. Mater. https://pubs.acs.org/doi/abs/10.1021/acs.chemmater.7b05133
title: Shared Decision Making Best Practices
Creators: name: Misra, Joya
Publisher: name: University of Massachusetts Amherst
Year: 2020

description: There are many potential topics for shared decision-making in departments. Some of the most common, and most challenging, include: Recommending faculty hires to Dean Suggesting Chair appointments to Dean Adopting/amending bylaws Tenure and promotion deliberation process Electing faculty to committees Changing curricula Recommending office space/lab allocations Merit deliberations Faculty can be involved in many other different kinds of decisions, such as identifying speakers to invite to campus, student awards, ensuring faculty and student success, and other activities.
Critical phenomena in gravitational collapse
Creators: name: Gundlach, Carsten
name: Martin-Garcia, Jose M.
Publisher: name: arXiv
Year: 2007
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: As first discovered by Choptuik, the black hole threshold in the space of initial data for general relativity shows both surprising structure and surprising simplicity. Universality, power-law scaling of the black hole mass, and scale echoing have given rise to the term "critical phenomena". They are explained by the existence of exact solutions which are attractors within the black hole threshold, that is, attractors of codimension one in phase space, and which are typically self-similar. Critical phenomena give a natural route from smooth initial data to arbitrarily large curvatures visible from infinity, and are therefore likely to be relevant for cosmic censorship, quantum gravity, astrophysics, and our general understanding of the dynamics of general relativity.
description: 51 pages, 5 figures. Major update of Living Rev. Rel. 2 (1999) 4
The spectral dimension controls the decay of the quantum first detection probability
Creators: name: Thiel, Felix
name: Kessler, David A.
name: Barkai, Eli
Publisher: name: arXiv
Year: 2018
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We consider a quantum system that is initially localized at $x_{in}$ and that is repeatedly projectively probed with a fixed period $τ$ at position $x_d$. We ask for the probability that the system is detected in $x_d$ for the very first time, $F_n$, where $n$ is the number of detection attempts. We relate the asymptotic decay and oscillations of $F_n$ with the system's energy spectrum, which is assumed to be absolutely continuous. In particular $F_n$ is determined by the Hamiltonian's measurement spectral density of states (MSDOS) $f(E)$ that is closely related to the density of energy states (DOS). We find that $F_n$ decays like a power law whose exponent is determined by the power law exponent $d_S$ of $f(E)$ around its singularities $E^*$. Our findings are analogous to the classical first passage theory of random walks. In contrast to the classical case, the decay of $F_n$ is accompanied by oscillations with frequencies that are determined by the singularities $E^*$. This gives rise to critical detection periods $τ_c$ at which the oscillations disappear. In the ordinary case $d_S$ can be identified with the spectral dimension found in the DOS. Furthermore, the singularities $E^*$ are the van Hove singularities of the DOS in this case. We find that the asymptotic statistics of $F_n$ depend crucially on the initial and detection state and can be wildly different for out-of-the-ordinary states, which is in sharp contrast to the classical theory. The properties of the first detection probabilities can alternatively be derived from the transition amplitudes. All our results are confirmed by numerical simulations of the tight-binding model, and of a free particle in continuous space both with a normal and with an anomalous dispersion relation. We provide explicit asymptotic formulae for the first detection probability in these models.
description: 20 pages, 7 figures
Teatro e Musica nel «Mistero provenzale di Sant’Agnese»
Creators: name: De Santis, Silvia
Publisher: name: Avellino : Associazione culturale Internazionale Sinestesie
Year: 2019
Subjects: Teatro
Musica
Medievale
Contrafactum
Drama
Music
Medival

description: Il contributo prende in esame la messinscena del Mistero provenzale di Sant’Agnese, generalmente considerato come il reperto più rilevante della produzione del teatro medievale in lingua occitana. Partendo dallo studio delle ‘note di regia’ presenti nell’unico manoscritto che tramanda l’opera (BAV, Chig. C.V.151), vengono descritti e analizzati lo spazio scenico, la scenografia, gli effetti di luce, i costumi, gli “effetti speciali” e la recitazione, rivolgendo, inoltre, particolare attenzione alla funzione drammatica dei numerosi e importanti inserti musicali del testo.
description: The article axamines the staging of the ‘Mistero provenzale di Sant’Agnese’, generally considered as the most relevant testimony of the Occitan medieval dramatic production. Starting from the study of the numerous stage directions contained in the only manuscript which transmits the work (BAV, Chig. C.V.151), the stage and scenic units, scenography elements, lighting effects, costumes, “special effects”, and acting are described and analised, payng also special attention to the dramatic function of the musical insertions of the text.
Effects of schizophrenia, bipolar disorder, and haloperidol on the hippocampus: a proteomic approach.
Creators: name: Schubert, Klaus O.
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Effects of schizophrenia, bipolar disorder, and haloperidol on the hippocampus: a proteomic approach.
Additional file 2: of Novel long-range regulatory mechanisms controlling PKD2 gene expression
Creators: name: Moisan, Stéphanie
name: Levon, Stéphanie
name: Gall, Emilie Cornec-Le
name: Meur, Yannick Le
name: Audrézet, Marie-Pierre
name: Dostie, Josée
name: Férec, Claude
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: Table S2. PCR primer sequences used for cloning into the luciferase reporter construct (5′ - 3′). (PDF 12 kb)
Analytical solution for heat conduction due to a moving Gaussian heat flux with piecewise constant parameters
Creators: name: Forslund, Robert
name: Snis, Anders
name: Larsson, Stig
Publisher: name: arXiv
Year: 2018
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 65M80

description: We provide an analytical solution of the heat equation in the half-space subject to a moving Gaussian heat flux with piecewise constant parameters. The solution is of interest in powder bed fusion applications where these parameters can be used to control the conduction of heat due to a scanning beam of concentrated energy. The analytical solution is written in a dimensionless form as a sum of integrals over (dimensionless) time. For the numerical computation of these integrals we suggest a quadrature scheme that utilizes pre-calculated look-up tables for the required quadrature orders. Such a scheme is efficient because the required quadrature orders are strongly dependent on the parameters in the heat flux. The possibilities of using the obtained computational technique for the control and optimization of powder bed fusion processes are discussed.
title: ADCO, Comptes du Petit-Cîteaux (1477-1491) (11 H 1179), f. 00656
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte D'Or
name: Petot, Frédérique
name: Projet CBMA
name: Petot, Frédéric
name: CBMA/CG21/F.PETOT/2019
name: Archives Départementales De La Côte-D'Or
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: comptes

description: Comptes du Petit-Cîteaux (1477-1491), Archives départementales de la Côte-d'Or, (11 H 1179). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Comptes du Petit-Cîteaux (1477-1491), Archives départementales de la Côte-d'Or, (11 H 1179), f. 00656, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Additional file 1: of Community knowledge, attitudes and practices related to schistosomiasis and associated healthcare-seeking behaviours in northern Côte d’Ivoire and southern Mauritania
Creators: name: Amoin Koffi
name: Doumbia, Mohamed
name: Fokou, Gilbert
name: Keita, Moussa
name: Brama Koné
name: N’doumy Abé
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: Plant Biology

description: Multilingual abstracts in the six official working languages of the United Nations. (PDF 591 kb)
The functional roles of GPVI, GPIba, and PARs in the generation of platelet-derived reactive oxygen species.
Creators: name: Naadiya Carrim
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Platelet receptor ligation initiates multiple signalling pathways leading to platelet-specific events such as shape change, secretion, integrin αІІbβ3 activation and platelet aggregation. In addition to these events, albeit less understood, platelets generate reactive oxygen species (ROS). In phagocytic cells, ROS act as a defence mechanism, while in nonphagocytic cells, such as platelets, the function of ROS has not been well described. Previous studies have shown that platelet-generated ROS serve to activate platelets and are involved in cellular signalling. This thesis focuses on the specific roles of two key platelet receptors pivotal in haemostasis and thrombosis, the glycoprotein (GP)lb-IX-V complex and GPVI, and the signalling pathways induced through these receptors that lead to ROS production. An important role for focal adhesion kinase (FAK) in the GPVI pathway is described and it is shown that GPIbα, like GPVI, plays a role in platelet-derived ROS generation. Signalling proteins involved in protease activated receptor (PAR)-induced ROS formation are identified, and a functional role for PAR4 is described that is independent of PARI. Furthermore, a novel association between PAR4 and GPIbα in platelet-derived ROS generation is proposed. NOX1 is determined as the main source of ROS in platelets, regardless of the agonist employed, and is found to mediate thromboxane A2 (TxA2) generation, independent of platelet aggregation. In conclusion, ROS generation is an attractive potential target in cardiovascular disease. It remains to be established whether targeting ROS in cardiovascular disease provides an alternative, safer and more specific therapy than other anti-platelet drugs such as aspirin.
L’incanto dell’‘altrove’ nella poesia di Carlo Betocchi
Creators: name: Santoli, Carlo
Publisher: name: Avellino : Associazione culturale Internazionale Sinestesie
Year: 2018
Subjects: Carlo Betocchi
Altrove
Poesia
Realtà vince il sogno
Elsewhere
Poetry

description: L’‘altrove’ diviene la cifra del cammino di Carlo Betocchi, un itinerarium hominis in Deum compiuto nel reale. Il poeta – come il viandante – si volge all’‘oltre’, rendendo visibile, attraverso la parola poetica, l’originale messaggio evangelico, che attesta una profonda interiorità umana. La prospettiva ontologica trasmette a Betocchi un senso ampio e diffuso di gioia, che gli permette di sentirsi vivo fra le cose del mondo. E questa naturalezza e semplicità può scorgersi nella prima raccolta: Realtà vince il sogno del 1932, in cui la ricerca dell’eterno si invera in un mirabile scenario di consolazione e luce.
description: The “elsewhere” is the backbone of Carlo Betocchi’s work, an ‘itinerarium hominis in Deum’ made in real. The poet – as a wanderer – turns to the “afterworld”, making vsible – thanks to poetry – te original evangelical message which reveals a deep human interiority. Due to the ontological perspective, Betocchi feels a wide and spread joy which allows him to feel alive in the world. Such a candor and simplicity are present in the firse collection: ‘Realtà vince il sogno’ (1932), where the quest for eternity comes to life in an amazing ‘scenario’ of light and solace.
Extended Effective Field Theory of Inflation
Creators: name: Ashoorioon, Amjad
name: Casadio, Roberto
name: Cicoli, Michele
name: Geshnizjani, Ghazal
name: Kim, Hyung J.
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We present a general framework where the effective field theory of single field inflation is extended by the inclusion of operators with mass dimension 3 and 4 in the unitary gauge. These higher dimensional operators introduce quartic and sextic corrections to the dispersion relation. We study the regime of validity of this extended effective field theory of inflation and the effect of these higher dimensional operators on CMB observables associated with scalar perturbations, such as the speed of sound, the amplitude of the power spectrum and the tensor-to-scalar ratio. Tensor perturbations remain instead, unaltered.
description: new version matches the published version, includes adding few citations and correcting few typos
Baudelaire, interlocutore privilegiato dell’ermeneuta Ungaretti
Creators: name: Giurdanella, Laura
Publisher: name: Avellino : Associazione culturale Internazionale Sinestesie
Year: 2018
Subjects: Ungaretti
Baudelaire
Ricezione
Identificazione
Affinità
Saggi e lezioni
Reception
Identification
Affinity

description: Il presente contributo intende occuparsi del momento sorgivo dell’esperienza lirica di Giuseppe Ungaretti e, nello specifico, si propone di mettere in luce la consonanza con la poesia di Charles Baudelaire, padre dell’estetica moderna e faro dell’Ottocento il cui riverbero illumina ancora i poeti del Novecento. Come lavoro preliminare allo scavo intertestuale a livello della poesia, viene esplicitata la ricezione ungarettiana del poeta Baudelaire. L’influenza della cultura e della letteratura francese sul poeta italiano è stata oggetto di numerose ricerche le quali, secondo Giurdanella, non hanno prodotto contributi puntuali in merito all’affinità tra le opere dei due poeti. Pertanto, l’autrice tiene conto della produzione saggistica, delle traduzioni nonché delle lezioni di Ungaretti professore e il dato che le appare preminente è stato quello relativo a un Baudelaire maestro e riferimento costante, “compagno di vita” e interlocutore privilegiato.
description: The present study investigates Giuseppe Ungaretti’s first lyrical experience and more specifically, it wants to show the consonance with Charles Baudelaire’s poetry, father of modern aesthetics and the backbone of the 19th century who still sheds light on the 20th century poets. In order to examine the poems intertextually, it has been fundamental to highlight Ungaretti’s reception of Baudelaire’s poetry. Many researches have explored how the French culture and literature influenced the Italian poet. However, such studies havenot produced any precise contribution about the similarities between the two poets. Thus, musing on Ungaretti’s essays, traslations and lessons, Boudelaire seems to be a master,a benchmark, a "life partner” and a privileged interlocutor.
Extracting the Gamma Ray Signal from Dark Matter Annihilation in the Galactic Center Region
Creators: name: Dodelson, Scott
name: Hooper, Dan
name: Serpico, Pasquale D.
Publisher: name: arXiv
Year: 2007
Subjects: subject: Astrophysics (astro-ph)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The GLAST satellite mission will study the gamma ray sky with considerably greater exposure than its predecessor EGRET. In addition, it will be capable of measuring the arrival directions of gamma rays with much greater precision. These features each significantly enhance GLAST's potential for identifying gamma rays produced in the annihilations of dark matter particles. The combined use of spectral and angular information, however, is essential if the full sensitivity of GLAST to dark matter is to be exploited. In this paper, we discuss the separation of dark matter annihilation products from astrophysical backgrounds, focusing on the Galactic Center region, and perform a forecast for such an analysis. We consider both point-like and diffuse astrophysical backgrounds and model them using a point-spread-function for GLAST. While the results of our study depend on the specific characteristics of the dark matter signal and astrophysical backgrounds, we find that in many scenarios it is possible to successfully identify dark matter annihilation radiation, even in the presence of significant astrophysical backgrounds.
description: 8 pages, 5 figures. Minor changes, note added. Matches published version
'Il durevole segno luminoso’. Vittorio Bodini e Rafael Alberti
Creators: name: Giorgino, Simone
Publisher: name: Avellino : Associazione culturale Internazionale Sinestesie
Year: 2018
Subjects: Bodini
Alberti
Meridionalità
Meridionality

description: Il saggio approfondisce, anche attraverso lo studio di lettere e altri documenti inediti, il rapporto di amicizia e collaborazione artistica che lega il poeta e traduttore salentino Vittorio Bodini (1914-1970) e il poeta andaluso Rafael Alberti (1902-1999), intensificatosi a Roma fra il 1963, inizio dell’esilio italiano di Alberti, e il 1970, anno della prematura scomparsa di Bodini. Già dalle primissime fasi appare chiaro che il loro non è un semplice rapporto fra traduttore e autore, ma si tratta, piuttosto, della relazione fra un poeta e un altro poeta, o meglio fra uno scrittore ancora in cerca della sua voce più autentica e quello che egli considera un suo ‘fratello maggiore’. Il motivo della meridionalità, per esempio, con tutto il suo portato di cromatismi, penombre, il suo «sentimento drammatico dell’amore e dell’odio» – sono parole di Alberti – è uno dei tratti che accomunano le loro opere.
description: This essay deepens, also through the study of letters and other unpublished documents, the relationship of friendship and artistic collaboration that binds the poet and traslator from Salento Vittorio Bodini (1914-1970) and the andalusian poet Rafael Alberti (1902-1999), intensified between 1963, the beginning of Alberti’s Italian exile, and 1970, the year of the untimely death of Bodini. From the beginning it is clear that is not a simple relationship between a traslator and an author, but rather the relationship between a poet and another poet, or rather between a writer still in search of his most authentic voice and the he regards as his ‘big brother’. The motif of the merionality, for exampe, with all its colors, its dimness, its “dramatic feeling of love and hatred” -these are Alberti’s words- is one of the features that unite their works.
Additional file 3 of Isopsoralen ameliorates rheumatoid arthritis by targeting MIF
Creators: name: Han, Yi
name: Wang, Jinguang
name: Li, Shufeng
name: Li, Yi
name: Zhang, Yongli
name: Zhang, Ruojia
name: Zhang, Yuang
name: Fan, Huancai
name: Shi, Haojun
name: Pan, Jihong
name: Song, Guanhua
name: Ge, Luna
name: Wang, Lin
Publisher: name: figshare
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 3: Supplied Table 1.
Intrauterine Fetal Growth Restriction - New Insights into Prenatal Detection, Definition, Surveillance and Delivery
Creators: name: Unterscheider, Julia
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Fetal growth restriction (FGR) is a common complication of pregnancy. Data presented in this thesis, which mainly originate from the national multicentre Prospective Observational Trial to Optimise Paediatric Health in IUGR (PORTO) study, consolidate knowledge in FGR, and contribute new insights into this important clinical problem. For the purpose of this study, FGR was defined as estimated fetal weight (EFW) below the 10th centile for gestation based on population standards. Contemporary practice was initially evaluated through survey and confirmed the inconsistencies in definition and management of pregnancies with FGR among Irish obstetricians. The PORTO study recruited 1,116 non-anomalous fetuses with EFW <10th >centile; 1 in 20 infants (n=57) was affected by adverse perinatal outcome and 1 in 4 infants (n=312) required admission to neonatal intensive care. The objective of the primary analysis was to optimise the definition of FGR using population and customised standards and by analysing growth trajectories. Pregnancies at increased risk of adverse outcome were those with abnormal umbilical artery (UA) Doppler, EFWpublications, data showed that there was no single predominant pattern of Doppler deterioration occurring in one fetus over time. UA Doppler was found to be the most important vessel to inform perinatal outcome. Additional analyses focused on delivery outcomes and clinical decision making in FGR which showed that clinicians used ultrasound information to indicate delivery in 77% of cases. Evaluation of placental injuries in FGR identified villous developmental abnormalities as the most common lesion in infants with adverse perinatal outcome. Finally, this work was used to formulate an evidence-based care standard for FGR pregnancies in Ireland which resulted in the development of the first national clinical practice guideline on FGR. Together with published studies from the PORTO results, the guideline provides clinicians with evidence to improve and consolidate their current standard of care.
«La città morta» nel teatro all’aperto del Castello Regina Cornaro di Asolo (1935)
Creators: name: Pagani, Maria Pia
Publisher: name: Avellino : Associazione culturale Internazionale Sinestesie
Year: 2019
Subjects: Città morta
Gabriele d'Annunzio
Teatro all'aperto
Asolo
1935
Dead city
Open air theatre

description: Questo contributo considera l’allestimento della tragedia dannunziana “La città morta” nel teatro all’aperto del Castello di Asolo tenutosi il 24 agosto 1935, con replica il 31 agosto. Dedicato alla memoria di Eleonora Duse, ebbe la regia di Guido Salvini che elaborò accorti espedienti scenici per ricreare l’Argolide nel panorama del Grappa. Il successo riportato da Emma Gramatica, Memo Benassi e Giulio Stival rese questa rappresentazione davvero memorabile, nella storia del teatro en plein air negli Anni Trenta.
description: This paper analyzes the staging of the tragedy ‘The Dead City’ by Gabriele d’Annunzio in the open air theatre of the Castle in Asolo, held on 24 August 1935 (with a repeat performance on 31 August). Dedicated to the memory of Eleonora Duse, it was directed by Giulio Salvini, who invented clever scenic effects in order to recreate the Argolis in the panorama of Grappa. The success of the actors Emma Gramatica, Memo Benassi and Giulio Stival made this staging truly memorable, in the history of the ‘en plein air’ theatre in the 1930s.
Coexistence of superconductivity and short-range double-stripe spin correlations in Te-vapor annealed FeTe$_{1-x}$Se$_{x}$ with $x\le0.2$
Creators: name: Xu, Zhijun
name: Schneeloch, J. A.
name: Yi, Ming
name: Zhao, Yang
name: Matsuda, Masaaki
name: Pajerowski, D. M.
name: Chi, Songxue
name: Birgeneau, R. J.
name: Gu, Genda
name: Tranquada, J. M.
name: Xu, Guangyong
Publisher: name: arXiv
Year: 2018
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: In as-grown bulk crystals of Fe$_{1+y}$Te$_{1-x}$Se$_{x}$ with $x\lesssim0.3$, excess Fe ($y>0$) is inevitable and correlates with a suppression of superconductivity. At the same time, there remains the question as to whether the character of the antiferromagnetic correlations associated with the enhanced anion height above the Fe planes in Te-rich samples is compatible with superconductivity. To test this, we have annealed as-grown crystals with $x=0.1$ and 0.2 in Te vapor, effectively reducing the excess Fe and inducing bulk superconductivity. Inelastic neutron scattering measurements reveal low-energy magnetic excitations consistent with short-range correlations of the double-stripe type; nevertheless, cooling into the superconducting state results in a spin gap and a spin resonance, with the extra signal in the resonance being short-range with a mixed single-stripe/double-stripe character, which is different than other iron-based superconductors. The mixed magnetic character of these superconducting samples does not appear to be trivially explainable by inhomogeneity.
description: 6 pages, 6 figures
A Model for the Chemical Evolution of the Galaxy with Refuses
Creators: name: Rocha-Pinto, Helio J.
name: Arany-Prado, Lilia I.
name: Maciel, Walter J.
Publisher: name: arXiv
Year: 1994
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: A model is presented for the chemical evolution of the solar neighbourhood which takes into account three families of galactic objects, according to their condensation states: stars, refuses and gas. Stars are defined as every condensed objects with masses greater than or equal to the minimum mass which ignites hydrogen and which will give rise to an evolutionary track on the HR diagram to the left of Hayashi's limit; refuses include the remnants, which are compact objects resulting from stellar deaths, and the residues, which have masses not large enough to ignite hydrogen; gas is defined as the mass which can be condensed to form stars and/or residues. We have developed equations for the mass evolution of each family, and have studied the gas metallicity distribution within the framework of the instantaneous recycling approximation, adopting different initial conditions. In order to constrain the model parameters we have also used preliminary evaluations of comet cloud masses to investigate the role of the residues as sinks of heavy elements in the Galaxy.
description: 11 pages (figures and table upon request), Tex, Ap.Spac.Sci. (in press)
Avalanche in the Valley (Fermions, Anomaly and Unitarity in High-Energy Electroweak Interactions)
Creators: name: Guida, R.
name: Konishi, K.
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Problems related to fermions, unitarity and chiral anomaly in high energy electroweak interactions, are investigated. Particular attention is paid to the correct functional integration over fermion fields in the background of instanton-anti\-instanton type configurations. This leads to an expansion of correlation functions in terms of a small parameter, $ρ/R$, when the instanton-antiinstanton separation ($R$) is large compared to their sizes ($ρ$). Applying such a method to widely discussed cases of fermion-number violation in the electroweak theory, we conclude that there are no theoretical basis for expecting anomalous cross sections to become observable at energies in the $10$ TeV region.
description: 11 pages + 1 figure (not included)