cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Bispecific Antibodies for Radiotherapy of Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: There is a critical need for improved treatment strategies in breast cancer for women diagnosed with metastatic disease. In such clinical settings, the current therapy options result in survival periods of less than 2 years in most cases. These breast cancer metastases are in many organs (e.g. lung and bone) and direct surgical removal or external beam radiotherapy are merely palliative. However, radioimmunotherapy, which utilizes monoclonal antibodies attached to high-energy radioisotopes, have demonstrated promise in the treatment of metastatic cancer. In addition, radioimmunotherapy is able to target multiple metastasis throughout the body in a single treatment. While excellent results have been reported using radioimmunotherapy in lymphoma, the corresponding success in solid tumors has been limited. Drawbacks of radioimmunotherapy in the treatment of breast cancer include the low tumor accumulation of the radiolabeled monoclonal antibody due to the large size of the antibody molecule as well as "bystander" radiation delivered to normal tissue during tumor localization. Thus, improvements are needed to: (1) increase the radiation delivered to tumor, while (2) decreasing the radiation to normal tissue in order to give doses of radioactive drug that will destroy all tumor cells without causing toxicity to normal tissues.

 Our approach is to engineer antibody fragments to a cell surface glycoprotein, the MUC-1 antigen. This antigen is abundant on 90% of human breast cancers in forms not present in normal tissue. In preliminary work, we have generated antibodies to MUC-1, and genetically manipulated the antigen binding site (variable heavy and variable light chain) genes into single-chain antibody fragments. In this project, we will first characterize the potential utility of selected antibodies by binding studies on breast cancer cells lines and breast tumors. Those antibodies with the most favorable binding characteristics will be DNA sequenced. These will be modified and made into bifunctional agents that combine the ability to recognize the MUC-1 antigen and carry the radiometal chelate, 90Y-DOTA. Thus, the goal is to produce hybrid molecules containing both the breast cancer binding region and the radioactive chelate binding region on a single therapeutic agent. Finally, we intend to evaluate these bispecific antibodies in mice with human breast tumors to determine the appropriate phamacokinetic characteristics (i.e., blood half-life, biodistribution, tumor uptake, dosage, etc.).

 We hope that our approach using genetic engineered bispecific immunotherapeutics will allows us to overcome the limitations encountered using targeted radioimmunotherapy of advanced breast cancer.
Additional file 1: Figure S1. of Single molecule counting and assessment of random molecular tagging errors with transposable giga-scale error-correcting barcodes
Creators: name: Lau, Billy
name: Hanlee Ji
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Inorganic Chemistry
subject: Plant Biology
subject: Computational Biology

description: Pairwise comparison of EXB barcode subunits. Figure S2. Enzymatic construction of EXBs. Figure S3. EXB analysis workflow. Figure S4. Barcode correlation between paired-end EXB groups. Figure S5. Gene expression correlation between EXB-labelled transcriptome data at 10 ng input. Figure S6. Gene expression correlation between EXB-labelled transcriptome data at 1 ng input. Figure S7. Gene expression correlation between EXB-labelled transcriptome data at 100 pg input. Figure S8. Artefactual effects of random-mer-based expression analysis as a function of EXB expression level. Figure S9. Technical variation between counting methods. Table S1. List of barcodes generated by linear coding matrix. Table S3. Sequencing statistics for 10 ng input cDNA assays. Table S4. Sequencing statistics for 1 ng input cDNA assays. Table S5. Sequencing statistics for 100 pg input cDNA assays. Table S8. Comparison to other molecular barcoding sequencing methods. (PDF 7740 kb)
Corvonirmus pleuropelios Mey 2017
Creators: name: Gustafsson, Daniel R.
name: Bush, Sarah E.
name: Palma, Ricardo L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Phthiraptera
Philopteridae
Corvonirmus
Corvonirmus pleuropelios

description: Corvonirmus pleuropelios Mey, 2017
Corvonirmus pleuropelios Mey, 2017: 120, fig. 40, pl. V: fig. 6, pl. VI: fig. 1.
Type host: Corvus mellori Mathews, 1912 —little raven.
Type locality: Toganmain, Groongal New South Wales, Australia.
Remarks. The female subgenital plates of Co. pleuropelios Mey, 2017 and Co. orruaticus Mey, 2017 (plate VI: fig. 1 and plate IV: fig. 6, respectively) seem to differ and, although tenuously separated from the other two new species of Australian Corvonirmus described by Mey (2017), we accept Co. pleuropelios as a valid species. We have examined additional specimens from the type host of Co. pleuropelios and can confirm that it is a distinct species. However, a thorough redescription and more illustrations are needed to properly characterize this species.
description: Published as part of Gustafsson, Daniel R., Bush, Sarah E. & Palma, Ricardo L., 2019, The genera and species of the Brueelia - complex (Phthiraptera: Philopteridae) described by Mey (2017), pp. 252-284 in Zootaxa 4615 (2) on page 260, DOI: 10.11646/zootaxa.4615.2.2, http://zenodo.org/record/3244680
Disruption of Cyclin E/Cell Cycle In Breast Cancer Cells
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The ability of a cell to divide is highly regulated, and this regulation becomes defective in cancer. The progression (temporal and physical) of a cell through cell division is termed the ‘cell cycle’. Numerous genes have been identified that control the cell cycle. A critical phase is the transition from either a stationary (G0) or a growing cell (G1) into the phase of active DNA synthesis (S) immediately prior to cell division. The cellular protein factors that regulate the forward progression of the cell cycle are called cyclins. Mutations in the genes encoding cyclins have been detected in clinical breast tumors. In normal cell growth and division, the temporal expression and destruction of specific cyclins coordinate cellular activities required for ordered cell cycle passage. Significantly, it is during the first phase of the cycle, G1, that the cell makes the commitment to either (i) exit the cycle to differentiate, or (ii) begin DNA replication (S). Our research focus is the G1-S transition, which appears to be regulated by a specific cyclin, cyclinE (cycE). Mutations in the cycE gene have been observed both in cultured human breast cancer cells and in clinical breast tumors. Also, comparing normal human breast cells and breast tumors showed that cycE protein either was either present at a high level or was abnormally stable in the tumors.

 Our research will further define the role of cycE activity and the proteins it regulates in breast cancer. The most direct means of studying cycE is to deplete the cells of the protein and compare them with normal cells for cell cycle abnormalities. The key approach we will use is to block cycE protein production at the RNA level using two types of inhibitory molecules called either ‘antisense’ or ‘ribozymes’. These inhibitory molecules block the production of cycE protein, and we anticipate a possible reversion of the breast cancer phenotype to more normal cells. The cell systems used in this project include both normal and tumorigenic human breast epithelial cells.

 An improved understanding of cell cycle regulatory genes is essential to explain how carcinogens and genetic mutations cause uncontrolled tumor cell growth. Ultimately, this will greatly aid in the design and development of measures to prevent the initiation of breast cancer and therapies to combat it once it has developed.
Constraint interaction in Spanish /s/-aspiration: three Peninsular varieties
Creators: name: Morris, Richard E.
Publisher: name: Cascadilla Press
Year: 2000

description: Studies of aspiration in Peninsular Spanish usually concur that aspiration is characterized by considerable variation. Despite this variation, however, three clear patterns emerge: simple aspiration, gemination with preaspiration, and gemination. (e.g. obispo [obihpo], [obihppo], [obippo]). Unlike the voiceless stops and sonorants, the voiced obstruent series conditions a combination of aspiration, voicing assimilation, and segmental coalescence (e.g. resbalar [reFalar], desde [deTe], disgusto [dixuhto]). {Note: [F] = voiceless bilabial fricative; [T] = voiceless dental fricative} This paper presents a reanalysis of Peninsular data in which the three aspiration varieties represent different ways of satisfying the coda condition for Spanish, which varies across dialects but also conforms to universal norms, all the while maintaining maximal feature faithfulness. All three aspiration varieties require the suppression of some underlying structure and the reconfiguration of already existing structure. Two positional markedness constraints *C/[spread glottis] or *C/[continuant], which ban their respective features from syllable coda, force violation of lower-ranked IDENT [spread], IDENT [cont], DEP-LINK (No structural insertion), UNIFORMITY (No merging), and HAVE-PLACE (No placeless segments) in candidate evaluation. Progressively promoting *C/[spread] and demoting DEP-LINK results in increasingly unmarked coda structures, and models the diachronic tendency toward aspiration and ultimately segmental deletion. Secondary processes, such as preaspiration, gemination and coalescence, are shown to represent emergence of the unmarked.
Hormone Receptors and Breast Cancer Survival
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: We plan to study factors that affect survival from breast cancer. The hormone-receptor status of breast tumors is an important determinant of how a breast cancer patient will respond to therapy, and it is considered when determining a patient’s likelihood of survival. The major types of hormone receptors present on breast cells are estrogen and progesterone receptors. Estrogen receptors bind estrogen, a hormone that stimulates the growth of normal and cancerous breast tissue. Generally, women whose tumors have hormone receptors are more likely to survive than women whose tumors do not have hormone receptors. However, results from a recent study in Norway suggest that among women with similar tumor hormone-receptor status other factors may influence a woman’s chance of dying from her disease. In the study from Norway, the researchers found that overweight women whose breast tumors had hormone receptors were more likely to die from their disease than leaner women whose breast tumors had similar characteristics. We propose to investigate whether body weight and other factors such as prior use of hormone-replacement therapy and physical activity in any way influence the likelihood of death from breast cancer of women with given tumor hormone receptor status.

 The study will be carried out at the University of Southern California which has a formal Breast Cancer Research Program at the Norris Comprehensive Cancer Center. Using resources of the University of Southern California Cancer Surveillance Program, the population-based cancer registry for Los Angeles County, we will determine the survival status of women with breast cancer who participated in earlier studies of breast cancer risk factors. This information will then be used to determine a woman’s likelihood of dying given her tumor hormone-receptor status and other information such as her body weight, use of estrogen-replacement therapy, and physical activity levels at the time of her diagnosis with breast cancer.

 Despite massive research efforts, breast cancer death rates have not declined over the past decade. Identifying factors that influence disease progression and that are possible to change, such as body weight, physical activity habits or use of estrogen-replacement therapy, would help us better understand how tumors grow. It would give physicians additional strategies for managing their patients’ diseases and it would allow the patients to take a more active role in their care. In addition, this fellowship will give the Principal Investigator greater experience in breast cancer research, refining her expertise in hormone receptors and breast cancer.
Harmonic Serialism and Parallelism
Creators: name: McCarthy, John J.
Publisher: name: No Publisher Supplied
Year: 2000

description: The most familiar architecture for Optimality Theory is a fully parallel one, meaning that "all possible ultimate outputs are contemplated at once" (Prince and Smolensky 1993: &9). But Prince and Smolensky also briefly entertain a serial architecture for OT, called Harmonic Serialism. The idea is that Gen Eval iterates, sending the output of Eval back into Gen as a new input. This loop continues until the derivation converges (i.e., until Eval returns the same form as the input to Gen). There are clear resemblances between this approach and theories based on notions like derivational economy (e.g., Chomsky 1995). There is also a connection with serial rule-based phonology. In the implementation of Harmonic Serialism that Prince and Smolensky consider, each iteration of Gen is limited to making a single change in the input. The resulting derivation is quite similar to what rule-based phonology produces, if each rule is limited to the form A B/C77D, where A is a single segment.Apart from chapter 2 of Prince and Smolensky (1993), Harmonic Serialism has not figured very prominently in the literature, though with significant additional enhancements it has been used as a vehicle for incorporating rules into OT by Black (1993) and Blevins (199&).In this talk, I will look closely at Harmonic Serialism (without the enhancements). I will distinguish it from parallel OT and from other serial constraint-based theories such as Harmonic Phonology or "Stratal" OT. My goal is to develop a range of predictions made by Harmonic Serialism, under varying implementational assumptions, for phenomena that have been regarded as typical effects of serial derivation, such as phonological opacity. A key finding is that Harmonic Serialism doesn't improve much on classic parallel OT in analyzing opacity, and in certain other respects does significantly worse.
Additional file 1: of Identification and characterization of regulatory network components for anthocyanin synthesis in barley aleurone
Creators: name: Strygina, Ksenia
name: Börner, Andreas
name: Khlestkina, Elena
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: The presence of the HvMyc2-BA allele in barley Bowman NILs (1–2), parents of the mapping population used (3–4), recombinant DH lines of this population (5–96), accessions and cultivars from IPK Genbank (97–98) and ICG collection GenAgro (99–107). (PDF 149 kb)
BIOACTIVITIES OF SoRIP1, A TYPE 1 RIBOSOME INACTIVATING PROTEIN FROM SPINACIA OLERACEA
Creators: name: PAKEEZA ISMAIL
name: Dr. ALEENA SUMRIN
Publisher: name: Zenodo
Year: 2025
Subjects: Antibacterial, Antifungal properties, cytotoxic protein, Glycosidase activity, Ribosome inactivating protein.

description: Abstract

A single-stranded ribosome inactivating protein SoRIP1 from Spinacia oleracea (Spinach) is a 30 kDa protein. It is a multipurpose protein with versatile biological activities. This paper defines cloning and expression of SoRIP1 in bacteria to study its versatile biological properties and cytotoxic potential. The recombinant plasmid pET29a-SoRIP1 was synthesized and then transferred into top10 and BL21 (DE3) cells of Escherichia coli. The protein SoRIP1 was expressed after giving induction of 0.5 mM IPTG for 16 h at 37 ℃. The purification was achieved by Ni–NTA affinity chromatography. The protein SoRIP1 reserved its inherent biological activities like topological inactivation and N glycosidase activity when tested and exhibited hemaglutination activity as well. SoRIP1 demonstrated cytotoxicity against a liver carcinoma cell line (HepG-2) and human breast adenocarcinoma cell line (MCF-7). SoRIP1 protein when tested against pathogenic bacterial (Ralstonia solanaceum and Acinetobacter lwoffii) and fungal (Alternaria solani and Alternaria Alternata) strains demonstrated growth inhibiting effect. These results suggested that SoRIP1 may be a potential anticancer and antimicrobial agent to be used in medicinal and agricultural field.
Assimilation to the Unmarked
Creators: name: Bakovic, Eric
Publisher: name: University of Pennsylvania.
Year: 1999

description: In this paper I explain how an apparent problem arises when one considers input forms with uneven ratios of the values of an assimilatory feature. If the usual positional considerations of assimilation are irrelevant, then an effect dubbed 'majority rule' emerges. Majority rule is a pathological consequence of the vertical symmetry of input-output faithfulness whereby an arbitrarily better- represented feature value overrules the other value, resulting in assimilation of the latter to the former rather than vice-versa. I propose to circumvent the majority rule effect by invoking the local conjunction of co-relevant markedness and faithfulness constraints. A local conjunction of this type is asymmetrically violated by a mapping from an unmarked feature value to a marked one, and is universally ranked above its conjuncts -- its faithfulness conjunct in particular -- thereby heading off the apparent problem induced by the symmetry of faithfulness. This solution yields the successful description of an attested pattern, assimilation to the unmarked, which is furthermore claimed to correspond to the pattern of dominant-recessive vowel harmony.
Corvonirmus wakuiacus Mey 2017
Creators: name: Gustafsson, Daniel R.
name: Bush, Sarah E.
name: Palma, Ricardo L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Phthiraptera
Philopteridae
Corvonirmus
Corvonirmus wakuiacus

description: Corvonirmus wakuiacus Mey, 2017
Corvonirmus wakuiacus Mey, 2017: 120, figs 39, 43–44, pl. V: figs 4–5. Species inquirenda.
Type host: Corvus bennetti North, 1901 —little crow.
Type locality: Yeelirrie, Western Australia, Australia.
Remarks. This species is separated from other congeners by a single character: the reduction of the distal female subgenital plate. However, as shown by Mey (2017: 119, fig. 44a–f), this is a highly variable character, which is not clearly illustrated for any of the other three Australian species described by Mey (2017). Futhermore, comparing the photographs of Co. pleuropelios (Mey 2017: pl. VI: fig. 1) and that of Co. wakuiacus (Mey 2017: pl. V: fig. 5), it is impossible to ascertain whether the shape of the female subgenital plates of these species are significantly different. Mey (2017: 118) mentioned that one female Co. orruaticus has the subgenital plate reduced as in Co. wakuiacus, but this is not illustrated. Although we examined additional specimens from the type host, which appear to be conspecific with Co. wakuiacus, we consider Co. wakuiacus insufficiently diagnosed and regard it as species inquirenda.
description: Published as part of Gustafsson, Daniel R., Bush, Sarah E. & Palma, Ricardo L., 2019, The genera and species of the Brueelia - complex (Phthiraptera: Philopteridae) described by Mey (2017), pp. 252-284 in Zootaxa 4615 (2) on page 260, DOI: 10.11646/zootaxa.4615.2.2, http://zenodo.org/record/3244680
MOESM2 of Genome-wide scan for runs of homozygosity identifies potential candidate genes associated with local adaptation in Valle del Belice sheep
Creators: name: Mastrangelo, Salvatore
name: Tolone, Marco
name: Sardina, Maria
name: Sottile, Gianluca
name: Sutera, Anna
name: Gerlando, Rosalia Di
name: Portolano, Baldassare
Publisher: name: Figshare
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: Additional file 2: Figure S2. Total number of runs of homozygosity (ROH) longer than 1Â Mb and total length of genome (Mb) covered by ROH segments per individual. Observed (black) vs simulated (red) data.
Positional Asymmetries and Licensing
Creators: name: Zoll, Cheryl
Publisher: name: No Publisher Supplied
Year: 1998

description: The most restrictive version of Optimality Theory includes just three families of constraints: Markedness, Faithfulness and Alignment (Prince 199&). Using only these constraints there have been two basic approaches to licensing in phonology. In the first, licensing effects follow from context-specific markedness constraints such as those in (1). (1) Licensing is context-specific markedness: (Kiparsky 1995, Smolensky 1995, Ito and Mester 1996, Zoll 1996, Steriade 199& inter alia) License(voice): No voiced obstruents in coda position License(complex segment): A complex segment coincides with the first syllable Alternatively, others have argued that licensing constraints are context specific faithfulness constraints, exemplified by the POSITIONAL FAITH-FULNESS constraint shown in (2). (2) Licensing is context-specific faithfulness: (Selkirk 1994, Alderetem 1995, Beckman 1995, 199&, Casali 199&) IDENT-ONSET(voice): An onset segment is identical to its input correspondent with respect to voicing This paper, an expanded handout of a talk given at the LSA meeting in January 1998, demonstrates that licensing must be due to context- specific markedness constraints. The predictions of the two approaches differ in at least three ways, and in each case only context-specific markedness yields the correct result. In particular, the faithfulness version of licensing: (i) wrongly restricts the possible repairs of potentially unlicensed material; (ii) wrongly predicts that licensing will not be sensitive to derived properties; and (iii) cannot straight- forwardly account for necessarily negative licensing effects. It follows that while context-specific markedness constraints are indispensable, context-specific faithfulness is both inadequate and probably unnecessary for licensing. This result has important consequences for Optimality Theory more generally, since the expression of context-specific markedness appears to require the additional power of constraint conjunction (Smolensky 1995).
Alcohol Intake & Risk of Estrogen-Receptor Positive Br Ca
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: In this study, the association of alcohol intake with risk of breast cancer will be assessed separately for estrogen receptor-positive and estrogen receptor-negative tumors, using data from two large epidemiological studies of risk factors for breast cancer. Estrogen receptors are cellular proteins that bind estrogen, a hormone that stimulates growth of breast tissue. Breast tumor cells with higher levels of estrogen receptors (estrogen receptor-positive tumors) respond better to hormonal therapies than breast tumor cells with low levels of estrogen receptors (estrogen receptor-negative tumors). If alcohol intake is related only to estrogen receptor-positive tumors, this may clarify the role of alcohol in the etiology of breast cancer, and potentially support an estrogen-mediated effect of alcohol on breast cancer. In addition, an association of alcohol with risk of breast cancer that differs for estrogen receptor-positive and estrogen receptor-negative cancers would support the hypothesis that estrogen receptor status defines different types of breast cancer, rather than two stages in the development of one disease.

 Subjects are 2,330 women diagnosed for the first time with breast cancer (cases) and 2,330 women without breast cancer (controls) participating in two population-based case-control studies (Studies A and B) of risk factors for breast cancer. All subjects are white (Anglo or Hispanic) female residents of Los Angeles County. Each case subject is individually matched to a control subject on age, parity (Study A only), and neighborhood of residence. Eligible cases in Study A were women in Los Angeles County aged 40 years or younger diagnosed with in situ (localized) or invasive breast cancer from July, 1983, through December, 1988. Eligible cases in Study

 B were women in Los Angeles County aged 55-64 years diagnosed with in situ or invasive breast cancer from March, 1987, through December, 1989. Alcohol consumption, demographics, and other information were obtained in interview questionnaires. Estrogen receptor status was determined for all case subjects, but for 80 percent of the subjects the original pathology laboratories must be queried for the results. Appropriate statistical analyses will be used to estimate the association of alcohol intake with risk of estrogen receptor-positive and estrogen receptor-negative breast cancer.

 The results of this research may increase understanding of mechanisms through which alcohol might increase the risk of breast cancer, and the postdoctoral fellow will gain valuable experience working in a renowned breast cancer research program, leading to a career in breast cancer research.
Implementation of a behavior management program in a residential school
Creators: name: Barakat, Nicole M.
Publisher: name: No Publisher Supplied
Year: 2014

description: Educational programs that serve youth with emotional and behavioral disabilities (E/BD), including residential treatment centers, often utilize behavioral techniques and behavior management programs such as Positive Behavior Supports (PBS) to decrease student maladaptive behavior, and increase adaptive behavior.  The successful implementation of behavior management programs is influenced by a variety of factors related to the organizational context.  However, few program evaluation studies have looked specifically at factors that influence the implementation of behavior management programs in specialized school settings for students with E/BD.  New Jersey Private School (NJPS), a residential treatment center for boys with E/BD, requested a program evaluation in order to assess the implementation and outcomes of their behavior management system.  Staff surveys were used to answer program evaluation questions regarding implementer knowledge, self-reported use, attitudes, perceptions of administrative support, and perceptions of student responsiveness towards programs.  School observations and a review of permanent records were conducted in order to answer additional questions regarding fidelity and student behavioral outcomes.  Teachers who reported using behavior management programs consistently were found to have more knowledge and more positive attitudes towards programs.  Additionally, teachers’ positive perceptions of administrator support were found to be related to overall positive attitudes towards programs, as well as to fewer behavioral incidents in their classrooms.  Barriers to implementation identified by this survey included a lack of knowledge of behavioral theory and techniques, and poor perceptions of consistency of implementation, communication, and team work amongst staff.  Staff identified training and performance feedback as two areas of need.  In general, teachers’ knowledge, and their positive perceptions of both programs and administrator support were strongly associated with higher implementation and more successful outcomes for students.  Ultimately, the results of this study suggest that in order to ensure successful implementation of behavior management programs, administrators must focus on providing implementers with the supports necessary to maintain high knowledge and positive attitudes, including ongoing training, performance feedback, and facilitation of cohesion amongst staff.
Additional file 2: Figure S3. of Development of F1 hybrid population and the high-density linkage map for European aspen (Populus tremula L.) using RADseq technology
Creators: name: Zhigunov, Anatoly
name: Ulianich, Pavel
name: Lebedeva, Marina
name: Chang, Peter
name: Nuzhdin, Sergey
name: Potokina, Elena
Publisher: name: Figshare
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified

description: Information about 138 sequenced ddRAD libraries and reads successfully mapped to the P. trichocarpa reference genome. (PDF 391Â kb)
HSP27 Regulation of Breast Tumor Blood Vessel Growth
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The growth and spread of breast cancer is dependent on the establishment of a blood supply to the cancerous tumor. This is accomplished by the extension of existing blood vessels into the tumor mass by the migration and growth of the endothelial cells which line the intruding blood vessels. Highly vascularized tumors are generally larger and more likely to spread to other organs. The extent of tumor vascularization, therefore, is correlative with the risk of morbidity. Understanding how the generation of a tumor blood supply is regulated is essential to the understanding of the progression of the disease and may provide future avenues of prevention. Work in our laboratory has identified a small heat shock protein (HSP27) as a potential regulator of vessel growth. Increasing HSP27 levels by placing the human gene into bovine arterial endothelial cells results in enhanced growth and migration. HSP27 has been of interest to cancer researchers and oncologists because estrogen treatment of certain breast cancer cells, which causes accelerated growth of these cells, also causes increased HSP27 production. Since endothelial cell HSP27 is also responsive to estrogen, we propose that endothelial cell HSP27 regulates the vascularization of tumors which generate estrogen and/or grow in a milieu where estrogen is a key regulatory factor, e.g., breast carcinoma.

 To test this hypothesis, the following is proposed. First, the effects of estrogen treatment or the co-culture of breast cancer cells on the growth and migration of endothelial cells producing elevated HSP27 levels or mutant HSP27 will be measured. In addition, the effect of lowering endothelial cell HSP27 levels (through the infection of adenovirus vectors carrying anti-sense DNA) on these processes will be tested. Second, culture conditions will be modified to support the formation of capillary-like structures. The effect of estrogen or co-cultured breast tumor cells on the generation of these structures will be measured. Finally, mice expressing human HSP27 in addition to mouse HSP27 will be used to test the effect of elevated endothelial cell HSP27 levels on the formation of new blood vessels. The effect of elevated circulating and local estrogen levels (the latter approximating the effect of tumor-generated estrogen) will also be assessed. These studies address the complex communications which occur between breast tumor cells and invading vascular cells and will delineate the role of a key player in breast tumor vascularization.
Couala koaphilus Mey 2017
Creators: name: Gustafsson, Daniel R.
name: Bush, Sarah E.
name: Palma, Ricardo L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Phthiraptera
Philopteridae
Couala
Couala koaphilus

description: Koanirmus koaphilus Mey, 2017
Koanirmus koaphilus Mey, 2017: 127, fig. 53, pl. VI: fig. 6.
Couala koaphila (Mey, 2017). New combination.
Type host: Coua caerulea (Linnaeus, 1766) —blue coua.
Type locality: Madagascar.
Remarks. We place the only species described in Koanirmus as a valid species of Couala. However, a proper redescription of the single female holotype of Cl. koaphilus or its comparison against Cl. dodekopter, is needed to establish whether or not these two species are separable.
description: Published as part of Gustafsson, Daniel R., Bush, Sarah E. & Palma, Ricardo L., 2019, The genera and species of the Brueelia - complex (Phthiraptera: Philopteridae) described by Mey (2017), pp. 252-284 in Zootaxa 4615 (2) on page 261, DOI: 10.11646/zootaxa.4615.2.2, http://zenodo.org/record/3244680
Foleyellides mayenae Romero-Mayén & León-Règagnon, 2016, n. sp.
Creators: name: Romero-Mayén, Angeles R.
name: León-Règagnon, Virginia
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Nematoda
Chromadorea
Spirurida
Onchocercidae
Foleyellides
Foleyellides mayenae

description: Foleyellides mayenae n. sp.
(Figs. 1, 2)
Females more than three times longer than males. Body with anterior and posterior extremities round (Fig. 1 A, B). Maximum width at the esophagus-intestine junction level. Mouth small, oval, 2 parastomal structures present. Cephalic plate with 4 pairs of papillae,,two on each lateral lobe; external papillae larger than internal; amphids between papillae (Fig. 2 A). Lateral and caudal alae present in both sexes (Fig. 1 C, 2B, C). Esophagus long and divided in anterior muscular and posterior glandular parts. Glandular esophagus longer and thicker (Fig. 1 A).
MALES (based on 23 specimens). Body length 18.2-28.8 (21.44) mm. Maximum width at level of glandular esophagus 200–410 (310), width at nerve ring 110–210 (150), at muscular/glandular esophagus junction 110–210 (160), at esophagus—intestine junction 160–290 (260). Esophagus 830–1,460 (1,120), muscular region length 160–270 (210), width 30–49 (40); glandular region length 660–1,210 (900), width 69–130 (91). Nerve ring, anterior to esophagus division, at 120–210 (179) from anterior end. Five pairs of caudal papillae, sessile, mamiliform: 1 pair pre-anal, 1 adanal and 3 post-anal (Fig. 2 C, D). Their size decreasing towards posterior end. Preanal plaque absent. Spicules unequal in size, left larger than right, 280–440 (380) and 130–180 (150), respectively. Tail length 47–71 (60). Caudal alae reaching tail tip, only the posteriormost papillae; thinner at this level (Fig. 1 C).
FEMALES (based on 17 specimens). Body 41.5–93.8 (68.31) mm, maximum width at the anterior part of the intestine 410–850 (620). Width at nerve ring 140–240 (170), muscular/glandular esophagus junction 150–240 (180), at esophagus-intestine junction 260–530 (360), at vulva 240–470 (330). Esophagus 920–1,850 (1,380), muscular region length 180–350 (240) width 33–58 (40); glandular region length 830–1,630 (1,150), width 71–140 (100). Nerve ring at 130–240 (170) from the anterior end. Vulva anterior to junction of esophagus and intestine, 1,020–1,490 (1,024) from anterior extremity (Fig. 1 A). Tail length 110–260 (180) (n=19). Lateral alae present and reaching the end of the tail (Fig. 2 B).
description: Published as part of Romero-Mayén, Angeles R. & León-Règagnon, Virginia, 2016, A new species of Foleyellides (Nematoda: Onchocercidae) parasite of Lithobates spp. (Amphibia: Ranidae) from Mexico with a key for the species of the genus, pp. 581-586 in Zootaxa 4170 (3) on page 582, DOI: 10.11646/zootaxa.4170.3.10, http://zenodo.org/record/268226
Additional file 2: Figure S1. of Fine organization of genomic regions tagged to the 5S rDNA locus of the bread wheat 5B chromosome
Creators: name: Sergeeva, Ekaterina
name: Shcherban, Andrey
name: Adonina, Irina
name: Nesterov, Michail
name: Beletsky, Alexey
name: Rakitin, Andrey
name: Mardanov, Andrey
name: Ravin, Nikolai
name: Salina, Elena
Publisher: name: Figshare
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The PCR testing for the overlapping of BAC-clones of pool_52 (TaaCsp5BS025F09 and TaaCsp5BS010O13). The positions of BAC End Sequences for two fragments derived from TaaCsp5BS025F09 indicated by red arrows. The three pairs of ISBP primers were designed to TE insertions (Danae-1/Fatima: 5′-GACAAAAATGGCCAACATCC-3′ and 5′- GACCCCCTAATCCAGGACTC-3′; Fatima/Danae-1: 5′-TGTCCCCAGCCTCTTGTTAC-3′ and 5′- GTGAAGGTGCCAACGAACTC-3′; 5SrDNA/Laura: 5′-ACCCTAGTTGGTTTCAGAGG-3′ and 5′- TGGGTGCTCACGATTCAC-3′) are indicated by black arrows. Primers were tested on the individual BAC-DNA templates TaaCsp5BS025F09 and TaaCsp5BS010O13. The PCR amplification results for each primer pairs presented over the corresponding TE junction and demonstrate the overlapping of TaaCsp5BS025F09 and TaaCsp5BS010O13. (DOCX 152 kb)
A survey of New Jersey school psychologists' knowledge of cochlear implanted children
Creators: name: Dworkin, Chelsey Page
Publisher: name: No Publisher Supplied
Year: 2014

description: Cochlear implantation provides children with severe to profound sensorineural hearing loss the ability to achieve age-appropriate speech, language, and communication levels, and improved reading ability and literacy rates. With comprehensive habilitation services post-implementation, children with cochlear implants (CIs) have the opportunity to participate in inclusive educational programs. School psychologists (SPs) have an essential role in providing services and supports, and managing the educational needs of children with CIs in schools. In this study, a survey was conducted targeting SPs in New Jersey public schools to assess their knowledge and experience in working with children with CIs. Participants assessed a variety of areas relevant to the field including: background knowledge, classification and support services, programming, assessments, social emotional functioning, related services, and parent support. SPs also evaluated whether their school/district provided the necessary services and supports to assist children with CIs and their families sufficiently. The survey also queried possible challenges to the provision of services and desired resources to better service this population in public school settings. An electronic survey was created by the dissertation committee and emailed to all SPs in New Jersey public schools in order to receive a representative sample of the state. Contact information was gathered through Internet searches and telephone calls. An entire database of 1,&&& SPs were emailed to participate in the study, with 490 respondents (2&.5&%). Data were analyzed using descriptive statistics. Survey questions had varying numbers of useable responses, requiring individual item analysis. Responses to open-ended questions were reviewed individually and categorized in order to determine common themes. The various categorical findings indicate that SPs in New Jersey public schools have limited knowledge, skills, and awareness regarding children with CIs; however, public schools/districts in New Jersey are integrating and servicing children with CIs moderately well. Many SPs indicate the use of a needs-based and individualized approach when working with children with CIs, and the desire to receive more training and information regarding this population. The study’s practical implications, limitations, and future directions for research are discussed.
Novel Retinoids with Enhanced Anti-Breast Tumor Efficacy
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Standard breast cancer treatments include surgery, radiation, and chemotherapy. Patients having estrogen receptor-positive tumors may respond favorably to the anti-estrogen tamoxifen, but can experience side-effects and develop resistance within two years. Moreover, anti-estrogens fail in more invasive, malignant tumors that have lost growth dependence on estrogen. Retinoids are natural and synthetic derivatives of retinoic acid, an active form of vitamin A. Retinoids can inhibit the growth of various types of cancer cells. However, natural retinoids have a number of undesirable side effects. Many groups have looked for retinoid and retinoid-like compounds with improved anti-cancer efficacy without major side effects. Our work concerns the study of a novel group of compounds, called AHPNs, that appear to inhibit cancer growth by a different pathway than traditional retinoids. The synthesis of one such AHPN compound, which is our lead, has been a significant step because our preliminary results suggest novel and potent activity in inhibiting the growth of breast tumors.

 The key to our approach has been to synthesize retinoid-like compounds that do not bind to or activate the "traditional" retinoic acid receptor subtypes. The new compounds that we will prepare will be derived from our lead compound. We find that this lead causes programmed cell death (i.e., apoptosis) in both breast cancer cells and the blood vessel cells that form the vascular network of tumors. The first aim of our BCRP-funded project is to improve the anticancer activity of our initial lead with the help of a computer-modeling process that identifies a "pharmacophore", which will show the most important features in the AHPN class that cause cancer cell apoptosis. We are conducting this aim with colleagues at the Molecular Research Institute in Mountain View. The second aim is to gain more biological insight into how these AHPNs work against breast cancer and endothelial cells, and then to explore their use in relevant animal models of breast cancer. In summary, our overall goal is to pinpoint the cancer and endothelial cell signaling pathways that are affected by the AHPN derivatives. As a result, we can apply this knowledge to improve the anti-breast cancer activity of our new candidates over that of our original lead. We will also be able to show how the AHPN class might best be applied in a treatment setting.

 We believe that this approach has great promise because the AHPN derivatives can be readily prepared. Because they are small molecules, they could be considered for oral administration. Thus, they have the potential to be useful in the prevention of breast cancer.
A preliminary evaluation of a team-based institute model of professional development in bullying prevention
Creators: name: Velderman, Christopher John
Publisher: name: No Publisher Supplied
Year: 2014

description: Professional development has been thoroughly researched in the areas of teacher effectiveness and academic instruction.  Far less research has been completed to assess the elements of effective professional development as it pertains to prevention programming, whole-school change, and the training of non-teaching staff (e.g., mental health professionals).  The current study evaluated participant perceptions of the Bullying Prevention Institute (BPI), a team-based, institute style professional development program.  The 2011-2012 pilot year of BPI provided training to school districts in the areas of the New Jersey Anti-Bullying Bill of Rights Act, bullying prevention, bullying intervention, and the school-change process.  To accomplish this training, BPI’s approach contained previously identified elements of effective professional development programs.  Data  came from thematic analysis of interviews conducted with a subset of Anti-Bullying Coordinators (ABCs) as well as through survey measures which were open to all BPI participants.  Participants provided feedback on the structure, content, and overall impact of program activities.  Participants identified year-long duration, frequent and on-going contact, consultation, and working in teams (both within and across school districts) as beneficial elements in the structure of BPI.  Participants also reported that they benefitted from active learning opportunities, material that was aligned with state standards, and content that was relevant, meaningful, and specific.  They also found it helpful to work towards an identified goal: the creation of a comprehensive bullying prevention plan.  Following participation in BPI, ABCs reported implementing aspects of their bullying prevention plans, as well as intent to implement additional aspects of their plans in the future.  ABCs also reported that participation in BPI had led, in part, to changes in their school or district’s climate.  Increased knowledge in the areas of bullying prevention, bullying intervention, and the school-change process were also reported.  These findings confirm previous results related to the elements of effective professional development, and they show that these elements are also effective in training non-teaching staff and in the content area of prevention programming.  Implications for the development of future training programs are also discussed.