cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Using heparin molecules to manage COVID‐2019
Creators: name: Key, Nigel S.
name: Arnold, Katelyn
name: Pawlinski, Rafal
name: Liu, Jian
name: Li, Jine
Publisher: name: Elsevier
Year: 2020

description: The coronavirus disease 2019 (COVID-19) pandemic is becoming one of the largest global public health crises in modern history. The race for an effective drug to prevent or treat the infection is the highest priority among health care providers, government officials, and the pharmaceutical industry. Recent evidence reports that the use of low-molecular-weight heparin reduces mortality in patients with severe coronavirus with coagulopathy. Although the full scope of the benefits from heparin for COVID-19 patients is unfolding, encouraging clinical data suggest that heparin-like molecules may represent a useful approach to treat or prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The intent of this article is to offer our opinions on the mechanism(s) by which heparin may attenuate the course of SARS-CoV-2 infection. Furthermore, we propose a novel strategy to treat or prevent SARS-CoV-2 infection using "designer" heparin molecules that are fabricated using a synthetic biology approach.
Risk stratification and outreach to hematology/oncology patients during the COVID-19 pandemic
Creators: name: Ray, Emily M.
name: van Deventer, Hendrik
name: Rodriguez-O’Donnell, Julia
name: Osterman, Chelsea K.
name: Sanoff, Hanna K.
name: Bigelow, Sharon M.
name: Triglianos, Tammy
name: Winzelberg, Gary S.
name: Nichols, Angela D.
Publisher: name: Springer Nature
Year: 2020

description: Purpose Cancer patients have many medical and psychosocial needs, which may increase during the COVID-19 pandemic. We sought to (1) risk-stratify hematology/oncology patients using general medicine and cancer-specific methods to identify those at high risk for acute care utilization, (2) measure the correlation between two risk stratification methods, and (3) perform a telephone-based needs assessment with intervention for high-risk patients. Methods Patients were risk-stratified using a general medical health composite score (HCS) and a cancer-specific risk (CSR) stratification based on disease and treatment characteristics. The correlation between HCS and CSR was measured using Spearman’s correlation. A multi-disciplinary team developed a focused needs assessment script with recommended interventions for patients categorized as high-risk by either method. The number of patient needs identified and referrals for services made in the first month of outreach are reported. Results A total of 1697 patients were risk-stratified, with 17% high-risk using HCS and 22% high-risk using CSR. Correlation between HCS and CSR was modest (ρ = 0.41). During the first month of the pilot, 286 patients were called for outreach with 245 contacted (86%). Commonly identified needs were financial difficulties (17%), uncontrolled symptoms (15%), and interest in advance care planning (13%), resulting in referral for supportive services for 33% of patients. Conclusion There is a high burden of unmet medical and psychosocial needs in hematology/oncology patients during the COVID-19 pandemic. A telephone-based outreach program results in the identification of and intervention for these needs; however, additional cancer-specific risk models are needed to improve targeting to high-risk patients.
ความหมายและขอบเขตของการบัญชี
Creators: name: นิพันธ์ เห็นโชคชัยชนะ
Publisher: name: คณะพาณิชยศาสตร์และการบัญชี มหาวิทยาลัยธรรมศาสตร์
Year: 2016
Subjects: การบัญชี, วิชาชีพบัญชี, ขอบเขตของการบัญชี

description: วารสารวิชาชีพบัญชี JAP, 12, 35 (กันยายน 59)
การแก้ไขข้อผิดพลาดทางบัญชีเพื่อมุ่งสู่การทำบัญชีตามสภาพความเป็นจริง
Creators: name: สุพิชญ์ชญา เหล่าธรรมทัศน์
Publisher: name: คณะพาณิชยศาสตร์และการบัญชี มหาวิทยาลัยธรรมศาสตร์
Year: 2016
Subjects: การแก้ไขข้อผิดพลาด, การทําบัญชีตามสภาพความเป็นจริง, การปรับปรุงข้อผิดพลาด

description: วารสารวิชาชีพบัญชี JAP, 12, 35 (กันยายน 59)
The Controller's Function: The Work of the Managerial Accountant
Creators: name: ไพลิน ตรงเมธีรัตน์
Publisher: name: คณะพาณิชยศาสตร์และการบัญชี มหาวิทยาลัยธรรมศาสตร์
Year: 2016

description: วารสารวิชาชีพบัญชี JAP, 12, 35 (กันยายน 59)
Reviving Routine Gastrointestinal Endoscopy in the COVID-19 Era
Creators: name: Shaheen, Nicholas J.
name: Peery, Anne F.
name: Arora, Shifali
Publisher: name: Wolters Kluwer
Year: 2020

description: Routine gastrointestinal (GI) endoscopy has been on hold. This
pause was necessary while health care resources were concentrated
on the coronavirus disease 2019 (COVID-19) pandemic and our
patients sheltered at home. Unfortunately, COVID-19 will likely
persist for months, if not years, in our communities. Although the
decision to resume routine GI endoscopy will depend on the
availability of resources, local trends in severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection, and state and
federal regulations, our units will eventually need to reopen for
routine endoscopy to provide appropriate care to our patients.
Coping With COVID-19: Learning From Past Pandemics to Avoid Pitfalls and Panic
Creators: name: Halperin, Daniel T.
Publisher: name: Johns Hopkins School Bloomberg School of Public Health, Center for Communication Programs
Year: 2020

description: It is imperative to concur on the main transmission routes of COVID-19 to explain risk and determine the most effective means to reduce illness and mortality. We must avoid generating irrational fear and maintain a broader perspective in the pandemic response, including assessing the possibility for substantial unintended consequences. As we wrestle with how best to mitigate COVID-19, it is imperative to concur on the likely main drivers of transmission (notably, infection clusters resulting from prolonged indoor respiratory exposure) in order to clearly explain risk and to determine the most effective, realistic behavioral and other means to reduce illness and mortality.At the same time, we must avoid generating irrational fear and maintain a broader perspective, including assessing the possibility for substantial unintended consequences from the response to the pandemic. As we wrestle with how best to mitigate COVID-19, it is imperative to concur on the likely main drivers of transmission (notably, infection clusters resulting from prolonged indoor respiratory exposure) in order to clearly explain risk and to determine the most effective, realistic behavioral and other means to reduce illness and mortality. At the same time, we must avoid generating irrational fear and maintain a broader perspective, including assessing the possibility for substantial unintended consequences from the response to the pandemic.
A Pathophysiological Model for COVID-19: Critical Importance of Transepithelial Sodium Transport upon Airway Infection
Creators: name: Rossier, Bernard C
name: Gentzsch, Martina
Publisher: name: Oxford University Press (OUP)
Year: 2020

description: The Coronavirus Disease 2019 (COVID-19) pandemic remains a serious public health problem and will continue to be until effective drugs and/or vaccines are available. The rational development of drugs critically depends on our understanding of disease mechanisms, that is, the physiology and pathophysiology underlying the function of the organ targeted by the virus. Since the beginning of the pandemic, tireless efforts around the globe have led to numerous publications on the virus, its receptor, its entry into the cell, its cytopathic effects, and how it triggers innate and native immunity but the role of apical sodium transport mediated by the epithelial sodium channel (ENaC) during the early phases of the infection in the airways has received little attention. We propose a pathophysiological model that defines the possible role of ENaC in this process.
Gaps in Knowledge About COVID-19 Among US Residents Early in the Outbreak
Creators: name: Bann, Carla M.
name: Lynch, Molly
name: MacDonald, Pia D.M.
name: Squiers, Linda
name: McCormack, Lauren A.
name: Frasier, Alicia M.
name: Bevc, Christine
Publisher: name: SAGE Publications
Year: 2020

description: OBJECTIVES: The novel coronavirus disease 2019 (COVID-19) resulting from severe acute respiratory syndrome coronavirus 2 began to affect the United States in early 2020. This study aimed to assess the US public's initial understanding about the disease and virus to inform public health communication efforts.
METHODS: We conducted a survey of US households from February 28 through March 2, 2020, using a probability-based web-panel survey of 1021 US residents. To assess knowledge about COVID-19, we asked respondents a series of 16 true/false questions. We conducted descriptive statistics and linear regression analyses to examine differences in knowledge scores based on demographic and background characteristics.
RESULTS: Knowledge about COVID-19 and the virus was relatively low overall at the beginning of the outbreak, with average scores of 62% on a 16-item knowledge index (ie, answers for 6 of the 16 questions were incorrect or unknown). Knowledge was especially low among people who had low education and income levels, were unemployed, were Hispanic, were non-Hispanic Black, were aged 18-24 and 35-49, indicated having "other" health insurance, and had limited exposure to information about the pandemic. Non-Hispanic Black respondents were less knowledgeable about COVID-19 and the virus at every education level compared with non-Hispanic White respondents at higher education levels. Non-Hispanic Black respondents with <high school degree were the least knowledgeable of all subgroups.
CONCLUSIONS: The findings of our study highlight the need for widespread, ongoing public health education about the virus and COVID-19, especially among certain populations. It is critical to effectively translate complex clinical and epidemiologic evidence into messages that most people can understand and act on during a pandemic, that combat misinformation about the virus and COVID-19, and that consider low levels of health literacy.
Half of Rural Residents at High Risk of Serious Illness Due to COVID‐19, Creating Stress on Rural Hospitals
Creators: name: Whitaker, Rebecca
name: Kaufman, Brystana G.
name: Pink, George
name: Holmes, G. Mark
Publisher: name: Wiley
Year: 2020

description: PURPOSE: During the COVID-19 epidemic, it is critical to understand how the need for hospital care in rural areas aligns with the capacity across states.
METHODS: We analyzed data from the 2018 Behavioral Risk Factor Surveillance System to estimate the number of adults who have an elevated risk of serious illness if they are infected with coronavirus in metropolitan, micropolitan, and rural areas for each state. Study data included 430,949 survey responses representing over 255.2 million noninstitutionalized US adults. For data on hospital beds, aggregate survey data were linked to data from the 2017 Area Health Resource Files by state and metropolitan status.
FINDINGS: About 50% of rural residents are at high risk for hospitalization and serious illness if they are infected with COVID-19, compared to 46.9% and 40.0% in micropolitan and metropolitan areas, respectively. In 19 states, more than 50% of rural populations are at high risk for serious illness if infected. Rural residents will generate an estimated 10% more hospitalizations for COVID-19 per capita than urban residents given equal infection rates.
CONCLUSION: More than half of rural residents are at increased risk of hospitalization and death if infected with COVID-19. Experts expect COVID-19 burden to outpace hospital capacity across the country, and rural areas are no exception. Policy makers need to consider supply chain modifications, regulatory changes, and financial assistance policies to assist rural communities in caring for people affected by COVID-19.
This Moment is the Curriculum: Equity, Inclusion, and Collectivist Critical Curriculum Mapping for Study Abroad Programs in the COVID-19 Era
Creators: name: Ohito, Esther O.
name: Lyiscott, Jamila
name: Wilcox, Susan E.
name: Green, Keisha L.
Publisher: name: SAGE Publications
Year: 2020

description: Background: This article explores critical curriculum mapping in experiential education through immersive travel or Study Abroad Programs (SAPs). Purpose: The tetrad of authors theorizes then models the practice of criticality in curriculum mapping for SAPs. Methodology/Approach: Using Black feminist thought as a theoretical moor and dialogue and reflexive narrative as methods, authors present a curriculum mapping framework that is berthed to collective knowledge of how Black women in the African diaspora make meaning of lived experience to survive a perpetually precarious world. Findings/Conclusions: The framework exemplifies an epistemological alternative to dominant individualistic Euro/American approaches to curriculum mapping. Such approaches privilege predictability and linearity, contributing to the low participation of collectivist-oriented Black, Indigenous, and People of Color (BIPOC) students in SAPs. Implications: A collectivist critical orientation to curriculum mapping may, therefore, be useful for (a) epistemologically diversifying curricular responsiveness (with implications for teaching and learning in the unpredictable chaos of the current COVID-19 moment) and (b) addressing enduring issues of equity and inclusion in SAPs.
A Primary Care Response to COVID‐19 for Patients with an Opioid Use Disorder
Creators: name: Ramage, Melinda
name: Fagan, E. Blake
name: Wilson, Courtenay Gilmore
Publisher: name: Wiley
Year: 2020

description: The Coronavirus Disease of 2019 (COVID-19) has
prompted adaptations and restructuring of almost every
institution in the nation. While these efforts to mitigate
the spread of COVID-19 affect everyone, patients treated
with buprenorphine/naloxone for an opioid use disorder
(OUD) will feel these disruptions more acutely, especially
in rural communities
Comprensión lectora y aprendizaje de palabras durante la lectura
Creators: name: Gutiérrez Sánchez, Susana Isabel
name: González Reyes, Ana Luisa
Publisher: name: Revista de Investigación Educativa, Intervención Pedagógica y Docencia
Year: 2024

description: Se ha demostrado que la lectura es una fuente importante de adquisición de vocabulario; no obstante, se propone que para que los alumnos aprendan de forma eficiente palabras durante la lectura, deben tener una buena comprensión lectora. El objetivo de esta investigación es determinar la influencia que ejerce la habilidad de comprensión lectora sobre la capacidad para aprender nuevas palabras durante la lectura. Se aplicaron dos pruebas a una muestra de 102 alumnos de cuarto de primaria: una prueba estandarizada de comprensión de oraciones, comprensión de un texto en silencio y comprensión de un texto en voz alta, y una de aprendizaje de palabras durante la lectura, de creación propia. Posteriormente se analizaron los puntajes a través de las técnicas estadísticas de correlación y regresión jerárquica para observar el efecto de una habilidad sobre otra. Se encontró que la comprensión de textos en voz alta es el predictor más significativo en la capacidad para aprender palabras de los niños. A diferencia de investigaciones previas, este trabajo estudia el aprendizaje de niños hispanohablantes y utiliza pseudopalabras como estímulos.
description: Revista de Investigación Educativa, Intervención Pedagógica y Docencia, Vol. 2 Núm. 2 (2024): Revista de Investigación Educativa, Intervención Pedagógica y Docencia
Wissenskosmos. Eine Medieninstallation Der Slub Dresden
Creators: name: Mittelbach, Jens
name: Clemente, Mirko
Publisher: name: Zenodo
Year: 2016
Subjects: Datenvisualisierung
Regenburger Verbundklassifikation
Video-Installation

description: Eine Video-Installation in der Zentralbibliothek der SLUB Dresden: Visualisierung von Echtzeit-Daten aus dem SLUB-Katalog.
Bienestar social y compromiso académico predictores del bienestar académico en estudiantes mexicanos de educación superior
Creators: name: Chávez Ortega, Edgar Alejandro
Publisher: name: Revista de Investigación Educativa, Intervención Pedagógica y Docencia
Year: 2023

description: La investigación tuvo como objetivo identificar relación entre Bienestar Social, Compromiso Académico con el Bienestar Académico con jóvenes universitarios del área metropolitana de  México. Las variables predictivas de Bienestar Social y Compromiso Académico han sido estudiadas en su relación con otros factores en ámbito educativo, pero no con el Bienestar Académico. Con un diseño no experimental. La muestra estuvo conformada por 230 participantes (35.2% hombres y 64.8% mujeres) del área metropolitana de México. Se desarrollaron análisis de correlaciones y de regresión lineal múltiple con el método de entrada. Se observó que el Bienestar Social (β=.332, p.<0.01) y Compromiso Académico (β=.226, p.<0.01) predicen un 20.7% del Bienestar Académico. Los resultados también permiten seguir consolidando la asocian entre las variables.


 
description: Revista de Investigación Educativa, Intervención Pedagógica y Docencia, Vol. 1 Núm. 1 (2023): Revista de Investigación Educativa, Intervención Pedagógica y Docencia
Concepciones sobre los números decimales en futuros profesores
Creators: name: Sánchez Tapia, Juan José
Publisher: name: Revista de Investigación Educativa, Intervención Pedagógica y Docencia
Year: 2024

description: El propósito del presente artículo es dar a conocer el desarrollo y los resultados de un taller realizado vía remota dedicado a ampliar los conocimientos matemáticos sobre los números decimales. El objeto de estudio e intervención fueron ocho estudiantes de segundo semestre de una escuela Normal Rural del Estado de Zacatecas, en México. Debido a la llegada intempestiva del Sars-Cov2 en 2020, la preparación de actividades presenciales se adaptó para realizarse a distancia. Se inició con la aplicación de un diagnóstico para definir los contenidos adecuados. Se utilizó la plataforma Meet, los formularios de Google, las pizarras electrónicas y los teléfonos inteligentes como principales recursos para la acción. Los resultados muestran que los participantes avanzaron en sus conocimientos y su comprensión de los números decimales, así como en su capacidad de argumentación. La interacción y construcción social de los conocimientos fueron posibles a pesar del distanciamiento físico gracias a la permanente solicitud de comparar y justificar las respuestas de los distintos estudiantes utilizando los medios disponibles.
description: Revista de Investigación Educativa, Intervención Pedagógica y Docencia, Vol. 2 Núm. 2 (2024): Revista de Investigación Educativa, Intervención Pedagógica y Docencia
El nacimiento del sistema educativo militar, dirección general de educación militar en la república, 1931-1935.
Creators: name: Vidal Urrutia, Jorge Alberto
name: Monterrosas Suárez, Claudia
Publisher: name: Revista de Investigación Educativa, Intervención Pedagógica y Docencia
Year: 2024

description: El presente trabajo analiza una tema poco estudiado en la historia de las instituciones en México y en la historia de la educación retomaremos los argumentos expuestos en el proyecto de institucionalización de mediados de los años veinte, y exploraremos uno de los logros de la institucionalización del ejército mexicano, que al entrar por el camino de la revolución hecha gobierno se encuentra ante el problema de su profesionalización y para tal tenía que crearse una infraestructura sin precedentes en la historia del ejército mexicano, la cual respondiera a las necesidades materiales e ideológicas más apremiantes dentro del instituto armado.
Al día de hoy las fuerzas armadas en la nación destacan los diferentes frentes de la sociedad, en auxilio a la seguridad interna del país, como históricamente lo han realizado en auxilio a desastres con el plan DN III y hasta con traslado y cuidado de dosis de vacunas. Su papel profesional no tiene dudas ni cuestionamientos serios al respecto, sin embargo, resulta importante preguntarnos ¿si el proceso de profesionalización por medio de un sistema educativo militar incide en estos relevantes papeles?, de ser así ¿cómo ocurrió tal génesis?, producto de ¿qué contexto surge?, estas son interrogantes que esta investigación busca esclarecer.
description: Revista de Investigación Educativa, Intervención Pedagógica y Docencia, Vol. 2 Núm. 2 (2024): Revista de Investigación Educativa, Intervención Pedagógica y Docencia
spub-ri-2017-0122-File007 – Supplemental material for Inequalities in smoking and obesity in Europe predicted to 2050: Findings from the EConDA project
Creators: name: Pérez-Ferrer, Carolina
name: Abbygail Jaccard
name: Knuchel-Takano, Andre
name: Retat, Lise
name: Brown, Martin
name: Kriaucioniene, Vilma
name: Webber, Laura
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, spub-ri-2017-0122-File007 for Inequalities in smoking and obesity in Europe predicted to 2050: Findings from the EConDA project by Carolina Pérez-Ferrer Abbygail Jaccard, Andre Knuchel-Takano, Lise Retat, Martin Brown, Vilma Kriaucioniene and Laura Webber in Scandinavian Journal of Public Health
COVID‐19 pandemic perspectives: A scientific silver lining?
Creators: name: Wolberg, Alisa S.
name: Dobson, Dre'Von A.
Publisher: name: Elsevier
Year: 2020

description: Accounts of the numerous negative effects caused by COVID-19 are pervasive, but few perspectives have identified any positive impacts of this massive societal shift. This forum examines potentially positive changes that have occurred within the scientific community amid the chaotic pandemic. Among these positives are the formation of virtual supergroups and an interdisciplinary brain trust. In forcing scientists away from their lab benches, COVID-19 has created time and space for more conversations about science and experimental design. Being away from the lab in this time of social unrest has also given scientists time to directly address institutional racism and its suppression of diversity in science. Although COVID-19 has been an unforeseen disaster of epic proportions, some of the resulting changes in our scientific community should remain in place after the pandemic is over. By leveraging these small wins, we will undoubtedly return to our laboratories stronger, smarter, and more efficient.
COVID-19 and haematological malignancy: navigating a narrow strait
Creators: name: Rubinstein, Samuel M
name: Warner, Jeremy L
Publisher: name: Elsevier
Year: 2020

description: Patients with haematological malignancies face unique
infectious risks. Not only do their cancers typically directly
affect the immune system, but therapies can cause severe
myelosuppression and lymphodepletion, especially in
curative settings. Vigilance to avoid life-threatening
infection is a part of life for these patients and is crucial in
medical decision making. With this context, the COVID-19
pandemic has understandably shaken this community,
and more data to guide management are needed.
Recreational and philanthropic sectors are the worst-hit US industries in the COVID-19 aftermath
Creators: name: Roy, Satyaki
name: Ghosh, Preetam
name: Dutta, Ronojoy
Publisher: name: Elsevier
Year: 2020

description: Lockdown measures to curb the spread of COVID-19 has brought the world economy on the brink of a recession. It is imperative that nations formulate administrative policies based on the changing economic landscape. In this work, we apply a statistical approach, called topic modeling, on text documents of job loss notices of 26 US states to identify the specific states and industrial sectors affected economically by this ongoing public health crisis. Our analysis reveals that there is a considerable incongruity in job loss patterns between the pre- and during-COVID timelines in several states and the recreational and philanthropic sectors register high job losses. It further shows that the interplay among several possible socioeconomic factors would lead to job losses in many sectors, while also creating new job opportunities in other sectors such as public service, pharmaceuticals and media, making the job loss trends a key indicator of the world economy. Finally, we compare the low income job loss rates against overall job losses due to COVID-19 in the US counties, and discuss the implications of press reports on reopening businesses and the unemployed workforce being absorbed by other sectors.
Characteristics of COVID-19 clinical trials registered with ClinicalTrials.gov: cross-sectional analysis
Creators: name: Woodford, Ashley L
name: Platts-Mills, Timothy F
name: Jones, Christopher W
Publisher: name: BMJ
Year: 2020

description: OBJECTIVES: To characterise current COVID-19-related research activities.
DESIGN: Cross-sectional analysis.
SETTING: Clinical trials registered with ClinicalTrials.gov testing interventions relevant to COVID-19.
DATA SOURCES: ClinicalTrials.gov was searched for COVID-19 and related terms to identify trials registered between 1 December 2019 and 1 May 2020 that test interventions related to the COVID-19 pandemic.
MAIN OUTCOME MEASURES: We classified trials according to intervention type, and report key trial characteristics including recruitment status, location, funder type, target enrolment number, intervention model (single group, randomised or sequential assignment) and projected completion date.
RESULTS: Of the 630 identified clinical trials related to COVID-19, 509 (81%) involved the study of drugs or biological agents. Of these trials of drugs and biologics, 305 (60%) use an open-label design, 43 (8%) are single blinded (participant only) and 161 (32%) are double blinded (participant and investigator). 94 (18%) of the drug/biological trials are non-randomised. Either hydroxychloroquine or chloroquine is administered as part of the study protocol in 152 (30%) of the drug/biological trials. The total planned enrolment for these hydroxychloroquine/chloroquine trials is over 200 000 participants, which represents 65% of the total planned enrolment for all registered trials of drugs or biologics. There are also at least 25 registered trials of azithromycin (n=53), convalescent plasma (n=38), lopinavir/ritonavir (n=30), stem cell treatments (n=29) and tocilizumab (n=25). 142 trials were registered in the first 3 months of 2020, and 488 trials were registered between 1 April and 1 May 2020.
CONCLUSIONS: These findings demonstrate a robust research response to the COVID-19 pandemic, though many of the currently planned and ongoing trials focus on a small number of potential therapies, and many also lack essential design features and power necessary to provide accurate treatment effect estimates.
Beyond Traditional Advance Care Planning: Tailored Preparedness for COVID-19
Creators: name: Cavalier, Joanna S
name: Kamal, Arif H
name: Maguire, Jennifer M
Publisher: name: Elsevier
Year: 2020

description: To the Editor: At the time of writing, there have been more than 18.6 million patients across the world with the novel coronavirus disease 2019 (COVID-19).1 COVID-19 has drastically altered how we care for patients, requiring barriers between providers and patients who undermine the depth of conversations and the ability to keep patients and families truly informed. The pandemic has introduced both logistical and psychosocial challenges put forth by resource shortages, visitor restrictions, and requirements for social distancing. These challenges necessitate early and intentional conversations about preferences, values, and goals of care. This preparedness planning and documentation should address both general concerns and specific issues to the sequelae of COVID-19, allowing us to care for our patients in an informed and a respectful manner.
Factors affecting COVID-19 infected and death rates inform lockdown-related policymaking
Creators: name: Roy, Satyaki
name: Ghosh, Preetam
Publisher: name: Public Library of Science (PLoS)
Year: 2020

description: BACKGROUND: After claiming nearly five hundred thousand lives globally, the COVID-19 pandemic is showing no signs of slowing down. While the UK, USA, Brazil and parts of Asia are bracing themselves for the second wave-or the extension of the first wave-it is imperative to identify the primary social, economic, environmental, demographic, ethnic, cultural and health factors contributing towards COVID-19 infection and mortality numbers to facilitate mitigation and control measures.
METHODS: We process several open-access datasets on US states to create an integrated dataset of potential factors leading to the pandemic spread. We then apply several supervised machine learning approaches to reach a consensus as well as rank the key factors. We carry out regression analysis to pinpoint the key pre-lockdown factors that affect post-lockdown infection and mortality, informing future lockdown-related policy making.
FINDINGS: Population density, testing numbers and airport traffic emerge as the most discriminatory factors, followed by higher age groups (above 40 and specifically 60+). Post-lockdown infected and death rates are highly influenced by their pre-lockdown counterparts, followed by population density and airport traffic. While healthcare index seems uncorrelated with mortality rate, principal component analysis on the key features show two groups: states (1) forming early epicenters and (2) experiencing strong second wave or peaking late in rate of infection and death. Finally, a small case study on New York City shows that days-to-peak for infection of neighboring boroughs correlate better with inter-zone mobility than the inter-zone distance.
INTERPRETATION: States forming the early hotspots are regions with high airport or road traffic resulting in human interaction. US states with high population density and testing tend to exhibit consistently high infected and death numbers. Mortality rate seems to be driven by individual physiology, preexisting condition, age etc., rather than gender, healthcare facility or ethnic predisposition. Finally, policymaking on the timing of lockdowns should primarily consider the pre-lockdown infected numbers along with population density and airport traffic.
COVID-19–Related Glomerulopathy: A Report of 2 Cases of Collapsing Focal Segmental Glomerulosclerosis
Creators: name: Alhashimi, Fatema
name: Hu, Yanglin
name: Berhanu, Kabaye
name: Khanna, Siddharth
name: Malhotra, Varun
name: Bichu, Prasad
name: Magoon, Sandeep
Publisher: name: Elsevier
Year: 2020

description: Coronavirus disease 19 (COVID-19), an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with acute kidney injury, presumably due to acute tubular injury. However, this does not explain proteinuria, sometimes severe, and hematuria often observed. We present 2 African American patients with glomerulopathy demonstrated by kidney biopsy in the setting of acute kidney injury and COVID-19 infection. Kidney biopsy specimens showed a collapsing variant of focal segmental glomerulosclerosis in addition to acute tubular injury. Both patients were homozygous for apolipoprotein L1 (APOL1). COVID-19 infection likely caused the interferon surge as a second hit causing podocyte injury leading to collapsing focal segmental glomerulosclerosis. APOL1 testing should be strongly considered in African American patients with nephrotic-range proteinuria. More data from future kidney biopsies will further elucidate the pathology of kidney injury and glomerular involvement from COVID-19 infections.
Novel Antimicrobial Surfaces to Defeat COVID-19 Transmission
Creators: name: Narayan, Roger J.
name: Chrisey, Douglas B.
name: Cristescu, Rodica
Publisher: name: Springer Nature
Year: 2020

description: Antimicrobial surface coatings function as a contact biocide and are extensively used to prevent the growth and transmission of pathogens on environmental surfaces. Currently, scientists and researchers are intensively working to develop antimicrobial, antiviral coating solutions that would efficiently impede/stop the contagion of COVID-19 via surface contamination. Herein we present a flavonoid-based antimicrobial surface coating fabricated by laser processing that has the potential to eradicate COVID-19 contact transmission. Quercetin-containing coatings showed better resistance to microbial colonization than antibiotic–containing ones.
COVID-19-Compliant Strategies for Supporting Treatment Adherence Among People Living with HIV in Sub-Saharan Africa
Creators: name: Okumu, Moses
name: Nyoni, Thabani
Publisher: name: Springer Nature
Year: 2020

description: COVID-19 public health responses such as social distancing and shelter-in-place protocols are critical to preventing and containing the spread of coronavirus. Yet these important measures may also prevent people living with HIV (PLWH) from accessing needed antiretroviral (ART) treatments and reduce their likelihood of treatment adherence. PLWHs from sub-Saharan Africa (SSA) account
for about 67.5% of the 37.9 million PLWHs globally
COVID-19, instability and migrant fish workers in Asia
Creators: name: Kadfak, Alin
name: Havice, Elizabeth
name: Marschke, Melissa
name: Isopescu, Ilinca
name: Duker, Peter
name: Vandergeest, Peter
name: MacDonnell, Mallory
Publisher: name: Springer Nature
Year: 2020

description: This paper seeks to establish how COVID-19 is impacting migrant fish workers through focusing on two global fish hubs, Thailand and Taiwan. Through a careful review of the news reports, social media, and NGO reports and press releases, three significant themes emerged: employment disruptions due to seafood system instabilities; travel or mobility restrictions; and poor access to services such as health care or social programs. We unpack each theme in turn to spotlight the impacts COVID-19 is having on yet another vulnerable worker population, fish workers. We further reflect on what this pandemic reveals about unacceptable work in industrial fisheries and consider if the pandemic may be producing opportunities to advocate for better working conditions.
Buckle-Delamination-Enabled Stretchable Silver Nanowire Conductors
Creators: name: Yao, Shanshan
name: Liu, Yuxuan
name: Wu, Shuang
name: Hu, Xiaogang
name: Zhu, Yong
name: Huang, He Helen
Publisher: name: American Chemical Society (ACS)
Year: 2020

description: Controlled buckling and delamination of thin films on a compliant substrate has attracted much attention for applications ranging from micro/nanofabrication to flexible and stretchable electronics to bioengineering. Here, a highly conductive and stretchable conductor is fabricated by attaching a polymer composite film (with a thin layer of silver nanowires embedded below the surface of the polymer matrix) on top of a prestretched elastomer substrate followed with releasing the prestrain. A partially delaminated wavy geometry of the polymer film is created. During the evolution of the buckle-delamination, the blisters pop-up randomly but self-adjust into a uniform distribution, which effectively reduces the local strain in the silver nanowires. The resistance change of the conductor is less than 3% with the applied strain up to 100%. A theoretical model on the buckle-delamination structure is developed to predict the geometrical evolution, which agrees well with experimental observation. Finally, an integrated silver nanowire/elastomer sensing module and a stretchable thermochromic device are developed to demonstrate the utility of the stretchable conductor. This work highlights the important relevance of mechanics-based design in nanomaterial-enabled stretchable devices.
Benchmark neutrinoless double-β decay matrix elements in a light nucleus
Creators: name: Basili, R. A. M.
name: Lockner, M.
name: Vary, J. P.
name: Engel, J.
name: Maris, P.
name: Yao, J. M.
name: Hergert, H.
Publisher: name: American Physical Society (APS)
Year: 2020

description: We compute nuclear matrix elements of neutrinoless double-β decay mediated by light Majorana-neutrino exchange in the A=6 system. The goal is to benchmark two many-body approaches, the no-core shell model and the multireference in-medium similarity renormalization group (SRG). We use a SRG-evolved next-to-next-to-next-to-leading chiral order two-body potential for the nuclear interaction, and make the approximation that the isospin is conserved. We compare the results of the two approaches as a function of the cutoff on the many-body basis space. Although differences are seen in the predicted nuclear radii, the ground-state energies and neutrinoless double-β decay matrix elements produced by the two approaches show significant agreement. We discuss the implications for calculations in heavier nuclei.
Development and psychometric testingof the Chinese nurses job satisfaction scale
Creators: name: Liu, Ying
name: Yupin Aungsuroch
name: Jintana Yunibhand
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2016
Subjects: exploratory factor analysis,scale development,nurse job satisfaction,second-order confirmatory factor analysis

description: Songklanakarin Journal of Science and Technology (SJST), 38, 5
Evaluation of EED Inhibitors as a Class of PRC2-Targeted Small Molecules for HIV Latency Reversal
Creators: name: Strahl, Brian D.
name: James, Katherine S.
name: Winecoff, Daniel K.
name: Potjewyd, Frances
name: James, Lindsey I.
name: Archin, Nancie M.
name: Turner, Anne-Marie W.
name: Browne, Edward P.
name: Margolis, David M.
name: Kirchherr, Jennifer L.
name: Dronamraju, Raghuvar
Publisher: name: American Chemical Society (ACS)
Year: 2020

description: A hallmark of human immunodeficiency type-1 (HIV) infection is the integration of the viral genome into host chromatin, resulting in a latent reservoir that persists despite antiviral therapy or immune response. Thus, key priorities toward eradication of HIV infection are to understand the mechanisms that allow HIV latency and to develop latency reversal agents (LRAs) that can facilitate the clearance of latently infected cells. The repressive H3K27me3 histone mark, catalyzed by the PRC2 complex, plays a pivotal role in transcriptional repression at the viral promoter in both cell line and primary CD4+ T cell models of latency. EZH2 inhibitors which block H3K27 methylation have been shown to act as LRAs, suggesting other PRC2 components could also be potential targets for latency reversal. EED, a core component of PRC2, ensures the propagation of H3K27me3 by allosterically activating EZH2 methyltransferase activity. Therefore, we sought to investigate if inhibition of EED would also reverse latency. Inhibitors of EED, EED226 and A-395, demonstrated latency reversal activity as single agents, and this activity was further enhanced when used in combination with other known LRAs. Loss of H3K27me3 following EED inhibition significantly increased the levels of H3K27 acetylation globally and at the HIV LTR. These results further confirm that PRC2 mediated repression plays a significant role in the maintenance of HIV latency and suggest that EED may serve as a promising new target for LRA development.
Eating disorders genetics in Asia
Creators: name: Bulik, Cynthia M.
Publisher: name: Wiley
Year: 2020

description: A complete understanding of the genetic architecture of eating disorders requires adequately large sample sizes from individuals of all ancestries. Failure to include representative samples truncates understanding and may even exacerbate health disparities. Several countries in Asia have made rich contributions in psychiatric genetics; however, the eating disorders field requires concerted global efforts to increase representation from Asian ancestry populations to ensure that our global efforts accurately reflect the true distribution of eating disorders around the world and across ancestries.
Binge Drinking: Macropinocytosis Promotes Tumorigenic Growth of RAS-Mutant Cancers
Creators: name: Hobbs, G Aaron
name: Der, Channing J
Publisher: name: Elsevier
Year: 2020

description: The RAS oncoprotein drives elevated macropinocytosis, a metabolic process essential for cancer growth. A recent study by Ramirez et al. elucidated a mechanism whereby RAS controls V-ATPase association with the plasma membrane to drive RAC1 GTPase-dependent macropinocytosis. Potentially actionable targets to disrupt this RAS-dependent nutrient acquisition pathway were identified.
EX0909 mapping field trials, Leg 1 : Necker Ridge, August 21, 2009 to Sept 3, 2009 Honolulu, HI to Honolulu, HI
Creators: name: Malik, Mashkoor
name: VerPlanck, Nicola
name: Lobecker, Elizabeth
name: Stuart, Elaine
name: Sheehan, Jessica
name: LeBarage, Andrea
name: Hunt, Jonathan
name: Colello, Benjamin
Publisher: name: NOAA Office of Ocean Exploration and Research
Year: 2009
Subjects: subject: Scientific expeditions -- Hawaii -- Necker Island

description: The purpose of the cruise report is to briefly describe the data acquisition and processing without going into very detailed setup of the multibeam and ancillary sensors.
Ab Initio Treatment of Collective Correlations and the Neutrinoless Double Beta Decay of Ca48
Creators: name: Hergert, H.
name: Engel, J.
name: Wirth, R.
name: Rodríguez, T. R.
name: Yao, J. M.
name: Bally, B.
Publisher: name: American Physical Society (APS)
Year: 2020

description: Working with Hamiltonians from chiral effective field theory, we develop a novel framework for describing arbitrary deformed medium-mass nuclei by combining the in-medium similarity renormalization group with the generator coordinate method. The approach leverages the ability of the first method to capture dynamic correlations and the second to include collective correlations without violating symmetries. We use our scheme to compute the matrix element that governs the neutrinoless double beta decay of ^{48}Ca to ^{48}Ti, and find it to have the value 0.61, near or below the predictions of most phenomenological methods. The result opens the door to ab initio calculations of the matrix elements for the decay of heavier nuclei such as ^{76}Ge, ^{130}Te, and ^{136}Xe.
Increasing learning and engagement in cybersecurity through segmented and interactive modules
Creators: name: Raina, Sagar
Publisher: name: Maryland Shared Open Access Repository
Year: 2016

description: (D. Sc.) -- Towson University, 2016
description: Cybersecurity is a global crisis. Continuously increasing cyber threats and attacks have lead the United States to take several initiatives to produce skilled cybersecurity workforce professionals. One such initiative is the introduction of cybersecurity education in schools. Since a majority of cybersecurity problems are attributed to software vulnerabilities, there is a need for teaching secure coding and computer security concepts to students using effective cybersecurity learning modules. Learning intervention based on modules are common in computer science education. Some cybersecurity learning modules have been developed, including the Security Injections @Towson cybersecurity modules. Learning modules that present a large amount of content on a single web page in a linear format may lead to pedagogical issues including - 1) content skipping, and 2) lower student engagement and learning. Addressing these issues in web-based learning modules is critical at a time when module-based pedagogical approach is widely adopted by instructors in academia and industry. This research presents a theoretical framework that uses the e-learning design principles of segmentation and interactivity to address these issues; describes a system built on this framework; and tests its effectiveness through quasi-experimental studies using the Security Injections @Towson cybersecurity modules in computer literacy, Computer Science 0 (CS0) and Computer Science I (CS1) courses .

A total of four studies compare linear modules and segmented interactive modules using the two group control group experimental design in the following order - 1) student engagement evaluations using post surveys in spring 2014; 2) student learning (retention of knowledge and ability to apply knowledge) evaluations using pre-survey, post-survey in fall 2014 and spring 2015, 3) students’ content skipping evaluations using an eye-tracking in fall 2015 and spring 2016; and 4) usability evaluations using surveys in fall 2015. A significant increase in student engagement (p < 0.05), ability to apply knowledge (0.05) and students’ content reading (p < 0.05) was demonstrated by students using segmented-interactive modules compared to linear modules. The segmentedinteractive modules were found to be significantly (p < 0.05) more usable than the linear modules. In addition, students indicated higher interest towards segmented-interactive modules.
description: http://library.towson.edu/cdm/ref/collection/etd/id/54044
(Mis)Alignment of instructional policy supports in Pre-K and kindergarten: Evidence from rural districts in North Carolina
Creators: name: Cohen-Vogel, Lora
name: Sadler, James R.
name: Little, Michael
name: Merrill, Becca
Publisher: name: Elsevier
Year: 2020

description: Over the past few decades, instructional policy supports — encompassing standards, curricula, and assessments — have featured centrally in the education reform movement. So, too, have efforts to align them. In this article, we conduct interviews with local educators with responsibility for early education about the alignment of instructional supports in Pre-K and kindergarten. Perceptions among study participants indicate that the degree of alignment among standards, curricula, and assessments is stronger within Pre-K and kindergarten than it is between them. Reported reasons for weak alignment between Pre-K and kindergarten include a debate over the purposes of early childhood education, institutional silos, and procedures that disrupt data sharing and transition practices. We consider what participants identify as the barriers to alignment mean for the development of policies aimed at lifting them.
Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer
Creators: name: Anderson, Andrew O.
name: Wennerberg, Krister
name: Esposito, Dominic
name: DeLiberty, Jonathan M.
name: Campbell, Sharon L.
name: Petricoin, Emanuel F.
name: Papke, Bjoern
name: Wolpin, Brian M.
name: Bryant, Kirsten L.
name: Diehl, J. Nathaniel
name: Baker, Nicole M.
name: Der, Channing J.
name: Simanshu, Dhirendra K.
name: Hobbs, G. Aaron
name: Miermont, Anne M.
name: Waters, Andrew M.
name: Klomp, Jennifer E.
name: Cox, Adrienne D.
name: Rudloff, Udo
name: Goodwin, Craig M.
name: Pierobon, Mariaelena
name: Gautam, Prson
name: Hodge, Richard G.
name: Tran, Timothy H.
name: Thurman, Ryan D.
name: Ng, Raymond W.S.
name: Wang, Junning
name: Aguirre, Andrew J.
Publisher: name: American Association for Cancer Research (AACR)
Year: 2020

description: Allele-specific signaling by different KRAS alleles remains poorly understood. The KRASG12R mutation displays uneven prevalence among cancers that harbor the highest occurrence of KRAS mutations: It is rare (∼1%) in lung and colorectal cancers, yet relatively common (∼20%) in pancreatic ductal adenocarcinoma (PDAC), suggesting context-specific properties. We evaluated whether KRASG12R is functionally distinct from the more common KRASG12D- or KRASG12V-mutant proteins (KRASG12D/V). We found that KRASG12D/V but not KRASG12R drives macropinocytosis and that MYC is essential for macropinocytosis in KRASG12D/V- but not KRASG12R-mutant PDAC. Surprisingly, we found that KRASG12R is defective for interaction with a key effector, p110α PI3K (PI3Kα), due to structural perturbations in switch II. Instead, upregulated KRAS-independent PI3Kγ activity was able to support macropinocytosis in KRASG12R-mutant PDAC. Finally, we determined that KRASG12R-mutant PDAC displayed a distinct drug sensitivity profile compared with KRASG12D-mutant PDAC but is still responsive to the combined inhibition of ERK and autophagy. SIGNIFICANCE: We determined that KRASG12R is impaired in activating a key effector, p110α PI3K. As such, KRASG12R is impaired in driving macropinocytosis. However, overexpression of PI3Kγ in PDAC compensates for this deficiency, providing one basis for the prevalence of this otherwise rare KRAS mutant in pancreatic cancer but not other cancers.See related commentary by Falcomatà et al., p. 23.This article is highlighted in the In This Issue feature, p. 1.