cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 2: of The effect of optimised patient information materials on recruitment in a lung cancer screening trial: an embedded randomised recruitment trial
Creators: name: Adwoa Parker
name: Knapp, Peter
name: Treweek, Shaun
name: Vichithranie Madhurasinghe
name: Littleford, Roberta
name: Gallant, Stephanie
name: Sullivan, Frank
name: Schembri, Stuart
name: Rick, Jo
name: Graffy, Jonathan
name: Collier, David
name: Eldridge, Sandra
name: Kennedy, Anne
name: Bower, Peter
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Original patient information brochure. (DOCX 1004 kb)
title: ADCO, Cartulaire de Cîteaux pour les possessions de Dijon et du Dijonnais (XVe siècle), Cart. 175 (11 H 479), 115 folios, f. 0177
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2017
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Cartulaire de Cîteaux pour les possessions de Dijon et du Dijonnais (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 175 (11 H 479), 115 folios, f. 0177, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les possessions de Dijon et du Dijonnais (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 175 (11 H 479), 115 folios, f. 0177, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Strix nyctea Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Strigiformes
Strigidae
Strix
Strix nyctea

description: Strix nyctea [spec. nov.]
S. capite laevi, corpore albido maculis lunatis distantibus fuscis. Fn. svec. 54.
Aluco albus diurnus. Edv. av. 61. t. 61.
Habitat in Europa & America septentrionali.
Alba fereque immaculata in Alpibus Lapponicis.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 93, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
OH 1720 MHz Masers in Supernova Remnants --- C-Shock Indicators
Creators: name: Lockett, Phil
name: Gauthier, Eric
name: Elitzur, Moshe
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Recent observations show that the OH 1720 MHz maser is a powerful probe of the shocked region where a supernova remnant strikes a molecular cloud. We perform a thorough study of the pumping of this maser and find tight constraints on the physical conditions needed for its production. The presence of the maser implies moderate temperatures (50 -- 125 K) and densities ($\sim 10^5 cm^{-3}$), and OH column densities of order $10^{16} cm^{-2}$. We show that these conditions can exist only if the shocks are of C-type. J-shocks fail by such a wide margin that the presence of this maser could become the most powerful indicator of C-shocks. These conditions also mean that the 1720 MHz maser will be inherently weak compared to the other ground state OH masers. All the model predictions are in good agreement with the observations.
description: 16 pages, 5 Postscript figures (included), uses aaspp4.sty. To appear in the Astrophysical Journal
Estimate of time-scale for the current relaxation of percolative Random Resistor cum Tunneling Network model
Creators: name: Bhattacharya, Somnath
Publisher: name: arXiv
Year: 2018
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: The Random Resistor cum Tunneling Network (RRTN) model was proposed from our group by considering an extra phenomenological (semi-classical) tunneling process into a classical RRN bond percolation model. We earlier reported about early-stage two inverse power-laws, followed by large time purely exponential tail in some of the RRTN macroscopic current relaxations. In this paper, we investigate on the broader perspective of current relaxation. We present here an analytical argument behind the strong convergence (irrespective of initial voltage configuration) of the bulk current towards its steady-state, mapping the problem into a special kind of Gauss-Seidel method. We find two phenomenological time-scales (referred as $τ_t$ and $τ_s$), those emerge from the variation of macroscopic quantities during current dynamics. We show that not both, only one of them is independent. Thus there exists a {\it single} scale in time which controls the entire dynamics.
description: 7 Pages, 9 figures
Computational modelling and experimental evaluation of fluid and mass transport in lymph node with implications in inflammation
Creators: name: Jafarnejad, Mohammad
Publisher: name: Imperial College London
Year: 2016

description: The lymphatic system plays a critical role in normal physiology and is associated with pathologies from lymphoedema to cancer metastasis. A primary role of the lymphatic system is to transport lymph containing pathogens and immune cells from tissues to lymph nodes (LNs) where humoral and cellular adaptive immune response is initiated. Despite the importance of fluid and proteins transport to specific regions of the LN in proper immune response, little is known about fluid distribution and its modulation under different pathologic conditions such as inflammation. Four studies in this thesis set out to improve our understanding of how lymph transport in the LN modulates its function. The first study established a computational model of fluid flow in the LN demonstrating its important role in fluid exchange with blood vessels, and determined medulla hydraulic conductivity as the key parameter for controlling hydraulic resistance of the LN. In the second study, the experimentally measured LN resistance showed an increase after inflammation, which was associated with medulla hydraulic conductivity. The third study demonstrated an application of this model in providing insight into the role of lymph transport in formation of interfollicular chemokine gradients in the LN that are crucial for antigen presenting cell entry to LN paracortex. In the fourth study, the effect of shear stress that is present in the sinuses of the LN was examined on the calcium dynamics of the lymphatic endothelium. Overall, this research revealed that lymph flow both modulates (e.g. chemokine gradient formation and calcium signalling) and is modulated by (e.g. hydraulic resistance change with inflammation) LN function. The lymph flow plays a critical role in fluid balance and immune response and has a great potential as a therapeutic target for modulating immune response.
Identiﬁcation and characterisation of a novel aldo-keto reductase regulating sleep in Drosophila melanogaster
Creators: name: Petzold, Anne
Publisher: name: Imperial College London
Year: 2017

description: Sleep is an important behaviour that has been observed in all animals studied so far, including Drosophila melanogaster. While a range of studies demonstrates that sleep is crucial to preserve an animal’s cognitive and physical health, relatively little is known about its regulation. Speciﬁcally, the molecular mechanisms that regulate sleep are still unclear, although a strong heritable component prevails. While the gene network governing sleep timing – the circadian system – is comparatively well described, the network calibrating the sleep homeostat is still vague. The study of sleep-regulatory mechanisms was greatly advanced by the adoption of the relatively simple model organism Drosophila melanogaster. Following seminal studies that demonstrated the suitability of Drosophila for the study of sleep, several sleep mutants were identiﬁed. Among those, hyperkinetic – a member of the aldo-keto reductase (AKR) family of enzymes – was one of the ﬁrst Drosophila sleep mutants ever described. The abundance and importance of AKRs for human health and disease in combination with their conservation in Drosophila provides an excellent basis to examine whether AKRs systematically act as molecular regulators of sleep behaviour. Thus, we produced the ﬁrst in silico study of potential Drosophila AKRs. We experimentally tested potential AKRs for neural sleep-regulatory roles through a nervous system-wide and Mushroom body-speciﬁc screen. We identiﬁed and further characterised the neural populations expressing particular candidates and the role these candidate AKRs fulﬁl to modulate sleep behaviour. We identiﬁed a novel AKR, CG10638, which speciﬁcally acts through a pair of wake-promoting peptidergic projection neurons termed “inferior contralateral interneurons” (ICLI) whose inhibition is necessary to relieve sleep pressure built up during the day, or speciﬁcally induced through dedicated sleep deprivation. We also demonstrate that ICLI neurons receive inputs from the major ‘clock’ neurons of the ﬂy brain, and show that CG10638 negatively regulates ICLI neurons to acutely gauge the sleep homeostat and to integrate sleep pressure with the circadian network. We also identiﬁed a Mushroom body-speciﬁc sleep-regulatory AKR, CG3397, that may be close to Hyperkinetic in structure and function.
Cosmological constraints with self-interacting sterile neutrinos
Creators: name: Song, Ningqiang
name: Gonzalez-Garcia, M. C.
name: Salvado, Jordi
Publisher: name: arXiv
Year: 2018
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this work we revisit the question of whether Cosmology can be made compatible with scenarios with light sterile neutrinos, as invoked to explain the SBL anomalies, in the presence of self-interaction among sterile neutrinos mediated by massive gauge bosons. We examine this proposal by deriving the cosmological predictions of the model in a wide range of the model parameters including the effective interaction strength $G_X$, sterile neutrino mass $m_{\rm st}$ and active-sterile mixings. With those we perform a statistical analysis of the cosmological data from BBN, CMB, and BAO data to infer the posterior probabilities of the sterile self-interaction model parameters. BBN mostly provides information about the effective interaction strength and we find that $\log_{10}(G_X/G_F)\geq 3.6$ can describe the primordial abundances at 95% CL. Our analysis of CMB and BAO data show that when allowing a wide prior for the sterile neutrino mass its posterior is bounded to $m_{\rm st}\leq 0.91~{\rm eV}$ (95% CL) considering CMB data only and $m_{\rm st}\leq 0.37~{\rm eV}$ (95% CL) when adding the BAO information. So the mass bounds are slighly relaxed compared with that of a non-interacting sterile neutrino model but a sterile neutrino mass of 1 eV is still excluded at more than $2σ$ CL. Conversely if fixing the sterile neutrino mass and mixing to the values prefered by short baseline data we find that while that CMB data alone favors the self-interacting scenario, including the BAO information severly degrades the agreement with the model. Altogether we conclude then that adding the self-interaction can alleviate the tension between eV sterile neutrinos and CMB data, but when including also the BAO results the self-interacting sterile neutrino model cannot lead to a satisfactory description of the data.
description: 26 pages, 10 figures, 3 tables; Corrected assumption of entropy conservation. Added explicit comparison with previous results obtained with entropy conservation assumption. Qualitative results unchanged. Version accepted in JCAP
In vivo assessment of pathology in Parkinson’s disease with Positron Emission Tomography
Creators: name: Simpson, Benjamin
Publisher: name: Imperial College London
Year: 2014

description: Twenty-one non-demented Parkinson’s disease (PD) subjects had [11C]-(R)-PK11195, [11C]-PIB and [18F]-FDG PET scans to evaluate activated microglia, amyloid and cerebral metabolism, respectively; of these, 19 underwent repeat scanning at a mean interval of 21.4 months. Motor, cognitive and non-motor clinical assessments were conducted. 7 subjects with PD dementia had [11C]-PIB and [18F]-FDG scans. 8 [11C]-(R)-PK11195, 9 [11C]-PIB, and 8 [18F]-FDG control scans were obtained. [11C]-(R)-PK11195 uptake correlated with multiple motor and cognitive deficits and other non-motor clinical symptoms, suggesting that neuroinflammation associated with microglial activation is relevant to the clinical phenotypic expression from early disease onwards. Higher activated microglia burden was associated with greater cognitive deterioration, and may constitute a biomarker for risk of PD dementia. [11C]-PIB uptake was elevated throughout the neocortex and in the striatum in the non-demented PD group compared to controls, with a predilection for posterior cortical structures. [11C]-PIB uptake had increased in the non-demented PD group at interval scanning. [11C]-PIB retention in the PD dementia group was higher than in the non-demented PD group, with a relative excess of anterior cortical [11C]-PIB binding. Striatal [11C]-PIB retention correlated inversely with verbal fluency. Subjective motor disability, impaired verbal fluency, and communication difficulties were associated with frontal lobe [11C]-PIB uptake in the non-demented PD group, suggesting that amyloid may contribute to frontal lobe dysfunction in PD before the onset of dementia. In a separate study, 47 [18F]-FDG PET scans with comprehensive gait analysis data were acquired. Brain metabolic deficits, detected with [18F]-FDG PET, were associated with abnormalities in gait pace and variability. Reduced gait velocity correlated with hypometabolism in the brainstem, putamen, globus pallidus, cingulate and anterior neocortex. The same pattern of metabolic derangement was related to increased gait variability, but spared the brainstem. It is conceived that brainstem locomotor structure contribute to pace, a more rudimentary component of gait function, whilst excess variability is a consequence of impaired supratentorial control of brainstem locomotion structures. Excess gait variability in PD may represent failure of compensatory mechanisms localising to the basal ganglia and anterior neocortex, due to progressive intrinsic PD pathology in these structures.
The geology and geochemistry of the Sakatti Cu-Ni-PGE deposit, N. Finland
Creators: name: Brownscombe, William
Publisher: name: Imperial College London
Year: 2015

description: The Sakatti Cu-Ni-PGE (platinum group elements) deposit is a newly discovered mineral deposit in northern Finland. The deposit is a magmatic sulphide hosted in an ultramafic intrusion in the Central Lapland Greenstone Belt. The major lithologies and styles of mineralisation of the deposit are characterised and defined in this project and their origin investigated. The host rock is composed primarily of olivine with forsterite content between 0.85 and 0.91 and a Ni content between 3000-3700 ppm. This suggests that the olivine is undepleted with respect to Ni and has not been derived from a sulphide-saturated melt. The intrusion sits in a plagioclase-picrite and the locus of the deposit occurs at a change in gradient that occurs when the intrusion transgresses to a stratigraphically higher lithology. Sulphur isotope analysis shows that the Sakatti deposit has consistent δ34S values 2.6 ± 2.4 ‰. This is not consistent with the regional Matarakoski schists contributing S to the deposit.The deposit has unusually low Ni/Cu values, particularly the shallower portions. Magnetite trace element analysis, PPGE/IPGE values and Ni isotope analysis presented suggest that this is due to sulphide fractionation and loss of early fractionating Ni-rich sulphide cumulates. The PGE mineralogy in the Sakatti deposit is exclusively PGE tellurides, derived from sulphide melt. The dominance of tellurides leads to a wide array of moncheite-merenskyite-melonite compositions that is not seen elsewhere globally. A model is presented for the formation of the deposit where earlier Ni-rich cumulates are lost at an earlier stage in the conduit-like intrusion and remobilised by later silicate melt that does not re-equilibrate with the sulphides.
Additional file 1: of Predicting recurrence of Clostridium difficile infection following encapsulated fecal microbiota transplantation
Creators: name: Staley, Christopher
name: Kaiser, Thomas
name: Vaughn, Byron
name: Graiziger, Carolyn
name: Hamilton, Matthew
name: Tauseef Rehman
name: Song, Kevin
name: Khoruts, Alexander
name: Sadowsky, Michael
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Supplemental figures and tables. (DOCX 292 kb)
Towards an improved model of self-interacting dark matter haloes
Creators: name: Sokolenko, Anastasia
name: Bondarenko, Kyrylo
name: Brinckmann, Thejs
name: Zavala, Jesús
name: Vogelsberger, Mark
name: Bringmann, Torsten
name: Boyarsky, Alexey
Publisher: name: arXiv
Year: 2018
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this work, we discuss the relation between the strength of the self-interaction of dark matter particles and the predicted properties of the inner density distributions of dark matter haloes. We present the results of $N$-body simulations for 28 haloes performed with the same initial conditions for cold dark matter and for self-interacting dark matter, for a range of cross-sections. We provide a simple phenomenological description of these results and compare with the semi-analytical model typically used in the literature. Using these results, we then predict how the inner dark matter surface density and core radius should depend on the self-interaction cross-section for observed haloes.
description: Corresponds to published version
Additional file 5: of Pharmacological inhibition of LSD1 activity blocks REST-dependent medulloblastoma cell migration
Creators: name: Callegari, Keri
name: Maegawa, Shinji
name: Bravo-Alegria, Javiera
name: Gopalakrishnan, Vidya
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: A, Scatter plots of REST and HIF1A correlation across the whole SHH MB cohort and across each Cluster 1–6. Clusters 3 and 4 had majority of points located in the top right quadrant of the graph, indicating high expression of these transcripts, while Cluster 5 had lower left localization indicating lower expression levels. B, Scatter plots of REST and HIF1A transcript correlation in SHH MB patients from dataset GSE37418 (n = 10; r = 0.59; p
Is PB1-F2 a virulence factor for avian influenza virus in poultry?
Creators: name: James, Joe
Publisher: name: Imperial College London
Year: 2017

description: PB1-F2 is a small accessory protein encoded by influenza A viruses. In mammals it has been implicated in a wide range of functions which contribute to increased pathogenesis. In the avian host, PB1-F2 is understudied despite increased conservation of functional-length PB1-F2 in viruses isolated from avian compared to mammalian hosts. Therefore the aim of this thesis is to understand the contribution of the avian influenza virus PB1-F2 protein to virulence and pathogenesis in poultry. Isogenic viruses were generated that encoded a full-length or knock-out PB1-F2 protein in both H9N2 and H5N1 virus backgrounds. During experimental infection of chickens and chicken embryos, the presence of PB1-F2 correlated with reduced pathogenicity, the opposite observation published for mammalian hosts, yet prolonged infectious virus shedding, enhancing virus transmission to contact chickens. In vivo PB1-F2 coincided with a reduction in the transcript abundance of interferon stimulated genes and pro-inflammatory associated cytokines. Further in vitro characterisation identified that PB1-F2 from these avian viruses antagonises chicken type I interferon signalling and NF-κB responses through interactions with chicken variants of the signalling components MAVS and IKKβ in a similar fashion to PB1-F2 from human viruses in human cells. The potency with which each pathway was antagonised by PB1-F2 appeared to be in-part determined by the mitochondrial localisation and was strain dependent, determined by multiple residues in the C-terminal region of PB1-F2. The degree of mitochondria localisation exhibited by PB1-F2 also correlated with the ability to induce apoptosis, which in the H5N1 virus background impaired infectious virus titres. The work in this thesis leads to the hypothesis that in the avian host PB1-F2 is positively maintained due to the interaction with key innate immune proteins leading to innate immune antagonism, suppressing viral clearance and disease severity thus prolonging viral shedding and enhancing the transmission window in the field.
BATSE Observations of the Large-Scale Isotropy of Gamma-Ray Bursts
Creators: name: Briggs, Michael S.
name: Paciesas, William S.
name: Pendleton, Geoffrey N.
name: Meegan, Charles A.
name: Fishman, Gerald J.
name: Horack, John M.
name: Brock, Martin
name: Kouveliotou, Chryssa
name: Hartmann, Dieter H.
name: Hakkila, Jon
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We use dipole and quadrupole statistics to test the large-scale isotropy of the first 1005 gamma-ray bursts observed by the Burst and Transient Source Experiment (BATSE). In addition to the entire sample of 1005 gamma-ray bursts, many subsets are examined. We use a variety of dipole and quadrupole statistics to search for Galactic and other predicted anisotropies and for anisotropies in a coordinate-system independent manner. We find the gamma-ray burst locations to be consistent with isotropy, e.g., for the total sample the observed Galactic dipole moment differs from the value predicted for isotropy by 0.9 sigma and the observed Galactic quadrupole moment by 0.3 sigma. We estimate for various models the anisotropies that could have been detected. If one-half of the locations were within 86 degrees of the Galactic center, or within 28 degrees of the Galactic plane, the ensuing dipole or quadrupole moment would have typically been detected at the 99% confidence level. We compare the observations with the dipole and quadrupole moments of various Galactic models. Several Galactic gamma-ray bursts models have moments within 2 sigma of the observations; most of the Galactic models proposed to date are no longer in acceptable agreement with the data. Although a spherical Dark Matter Halo distribution could be consistent with the data, the required core radius is larger than the core radius of the Dark Matter Halo used to explain the Galaxy's rotation curve. Gamma-ray bursts are much more isotropic than any observed Galactic population, strongly favoring but not requiring an origin at cosmological distances.
description: Accepted for publication in ApJ, 1996 March 1. 40 pages of text and tables. A plain Postscript version, including additional tables and the figures (2.6 Mb) is available under "Research Articles" at http://xanth.msfc.nasa.gov/astro/batse/batse_home.shtml
Methods for analysis and integration of heterogeneous network data
Creators: name: Gligorijevic, Vladimir
Publisher: name: Imperial College London
Year: 2017

description: In many areas of science and technology data describing a phenomenon or a system of interest and its individual components can be obtained from different types of instruments, using different acquisition techniques and experimental setups. Furthermore, many systems can be characterized by different data sets obtained by observing the system from different perspectives, under different conditions, or at different points in time. For example, in biology and biomedicine, rapid technological advances have led to the production of such heterogeneous and multimodal data, and enabled construction of complex networks with various types of interactions between diverse biological entities. Conventional network data analysis methods were shown to be limited in dealing with such multi-relational network data, as they are designed specifically for analysis of single-relational networks. Therefore, in this Thesis, we propose novel integrative methods that can collectively mine multiple types of biological networks and create more accurate integrative models capable of producing more holistic, systems-level biological insights. The proposed methods are based on Non-negative Matrix Factorization, a dimensionality reduction technique, that is further extended for learning and modelling dependencies between large-scale heterogeneous and multimodal network data. Our methods have a wide range of applications of which we focus on those from systems biology and biomedicine, including protein function prediction, multiple network alignment, extraction of composite functional modules from multimodal biological networks, and problems in precision medicine, including patient strati cation, drug repurposing and cancer driver gene prediction. In each of these applications we show that our methods outperform existing methods, provide biological insights and generate novel hypothesis that could guide future research and biological experiments.
Strix stridula Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Strigiformes
Strigidae
Strix
Strix stridula

description: Strix stridula [spec. nov.]
S. capite laevi, corpore ferrugineo, remige tertia longiore. Fn. svec. 55.
Strix. Aldr. ornith. 561. t. 563. Will. ornith. 65. Raj. av. 25.
Habitat in Europa.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 93, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Renewable chitin based nanomaterials from fungi
Creators: name: Wan Nawawi, Wan Mohd Fazli
Publisher: name: Imperial College London
Year: 2016

description: Fungal cell walls are rich in structural fibers made of chitin and glucan. These fibers were covalently linked, forming a ready-made nanocomposite fabric which is potentially useful in the development of a single-sourced bioreinforcement material that combines the strength of chitin and the toughness of glucan. In this study, chitin-glucan material was extracted from common mushroom (Agaricus bisporus) and tree bracket fungi (Daedaleopsis confragosa). Animal chitin extracted from crab shells (Cancer pagurus) was used as a comparison. We adopted mild extraction process to preserve the native quality of chitin-glucan within the fungal source. Six themes will be discussed: (1) comparison between fungal-based and animal-based chitin, (2) the effect of grammage on fungal chitin film, (3) the effect of blending time on fungal chitin film, (4) composite preparation using combination of different fungal extracts, (5) preparation of high volume fraction fungal-based chitin laminates, and (6) utilization of fungal chitin nanofiber as a natural binder for loose flax fiber. Extracts from common mushroom were found to be (1) readily disintegrated into nanofiber dimension (10–20 nm wide, several micrometers long) without any post-mechanical treatment, (2) more hydrophobic than animal based chitin, and (3) possess a film forming capability. Extracts from tree bracket fungi assumes microfiber dimension (1–2 µm wide, several micrometers long) and require specialized equipment for further nanofibrillation. Chitin to glucan ratio in common mushroom was found to be nearly equal at 40:50, while glucan predominates in bracket fungi (chitin to glucan, 1:99). This translates to distinct mechanical properties, in which strong films having tensile strength of ~200 MPa were produced from common mushroom extract, while tough films with elongation at break exceeding 10% were produced from bracket fungi. The strength of common mushroom nanofibers is further extended as a reinforcement in epoxy laminated composite and as a binder for nonwoven flax preform.
Model-independent reconstruction of the linear anisotropic stress $η$
Creators: name: Pinho, Ana Marta
name: Casas, Santiago
name: Amendola, Luca
Publisher: name: arXiv
Year: 2018
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this work, we use recent data on the Hubble expansion rate $H(z)$, the quantity $fσ_8(z)$ from redshift space distortions and the statistic $E_g$ from clustering and lensing observables to constrain in a model-independent way the linear anisotropic stress parameter $η$. This estimate is free of assumptions about initial conditions, bias, the abundance of dark matter and the background expansion. We denote this observable estimator as $η_{\rm obs}$. If $η_{\rm obs}$ turns out to be different from unity, it would imply either a modification of gravity or a non-perfect fluid form of dark energy clustering at sub-horizon scales. Using three different methods to reconstruct the underlying model from data, we report the value of $η_{\rm obs}$ at three redshift values, $z=0.29, 0.58, 0.86$. Using the method of polynomial regression, we find $η_{\rm obs}=0.57\pm1.05$, $η_{\rm obs}=0.48\pm0.96$, and $η_{\rm obs}=-0.11\pm3.21$, respectively. Assuming a constant $η_{\rm obs}$ in this range, we find $η_{\rm obs}=0.49\pm0.69$. We consider this method as our fiducial result, for reasons clarified in the text. The other two methods give for a constant anisotropic stress $η_{\rm obs}=0.15\pm0.27$ (binning) and $η_{\rm obs}=0.53 \pm 0.19$ (Gaussian Process). We find that all three estimates are compatible with each other within their $1σ$ error bars. While the polynomial regression method is compatible with standard gravity, the other two methods are in tension with it.
description: 25 pages, 4 figures, 9 tables
Genetic and epigenetic regulation of gene expression in pancreatic islets
Creators: name: Nakic, Nikolina
Publisher: name: Imperial College London
Year: 2016

description: T2D is a complex disease with evidence of a strong genetic basis. Studies of the human pancreatic islets have provided valuable insight into the islet regulatory landscape and identified enrichment of T2D-associated variants in islet enhancers. The relationship between cis-regulatory variation and changes in gene expression, however, remains unclear. This question is challenging to address in human, as it calls for a systematic analysis of cis-regulatory variation and the impact it has on gene expression in the native genomic context. While a mouse model can be used for this purpose, the regulatory landscape of the mouse pancreatic islets has been poorly characterized. This thesis addresses the questions of genetic and epigenetic regulation of gene expression in pancreatic islets in two parts. First, a genome-wide map of several histone modifications and transcription factor binding sites is created for the mouse pancreatic islet. This enabled identification of the mouse islet regulatory elements and characterization of enhancer clustering, transcription factor occupancy and conservation. A systematic comparison of enhancer clustering between mouse and human islets identified species-common and species-specific subsets of the islet regulatory program, each associated to a distinct biological function of the pancreatic islet. Second, a hybrid mouse was used as a model where naturally occurring genetic variation drives changes in gene expression. High-density mapping of allelic regulatory activity, chromatin accessibility and transcription provided insight into the properties of both genes subject to cis-regulatory variation and the regulatory elements driving the change in expression. As a result, tissue-specific genes associated to clustered enhancers were shown to be most influenced by cis-regulatory variation. Additionally, enhancer clustering emerged as the dominant property of regulatory elements associated to changes in gene expression. Overall, this thesis advanced our knowledge of the mouse islet regulatory landscape and provided novel insight into the properties of functional cis-regulatory variation.
Additional file 1: of The effect of optimised patient information materials on recruitment in a lung cancer screening trial: an embedded randomised recruitment trial
Creators: name: Adwoa Parker
name: Knapp, Peter
name: Treweek, Shaun
name: Vichithranie Madhurasinghe
name: Littleford, Roberta
name: Gallant, Stephanie
name: Sullivan, Frank
name: Schembri, Stuart
name: Rick, Jo
name: Graffy, Jonathan
name: Collier, David
name: Eldridge, Sandra
name: Kennedy, Anne
name: Bower, Peter
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Checklist of items for reporting embedded recruitment trials, based on the guidelines for reporting embedded recruitment trials, which adapts Consolidated Standards of Reporting Trials (CONSORT) for embedded recruitment trials. (DOCX 17 kb)
Partially-observed Networks: Inference and Dynamics
Creators: name: Hoffmann, Till
Publisher: name: Imperial College London
Year: 2018

description: Observing networks completely is not always possible or practical. However, attributes of nodes can help us predict how they interact with one another---even when only partial observations are available. Based on this premise, we discuss four core concepts in this thesis. First, we model individuals as inhabitants of a social space spanned by their demographic attributes who connect with one another based on an unknown connectivity kernel. We develop the statistical techniques to learn the kernel from ego networks and infer friendship preferences from eleven survey datasets from the United Kingdom and the United States, as well as data we collected in three online surveys. Second, we use the kernel to develop an intuitive segregation measure applicable to discrete attributes, such as gender or ethnicity, and continuous attributes, such as age or income. For certain kernels, the measure reduces to a metric that allows us to quantify distance in a multidimensional social space. Third, we show that linear dynamics on large, spatially-embedded networks with a known connectivity kernel can be approximated by convolutional partial differential equations. We illustrate the spatial mean-field theory with two synthetic examples, demonstrate that coupled oscillators on networks behave wave-like at large scales, and test the approximation on a location-based social network. Finally, we develop a model-based community detection algorithm for time series. The hierarchical model allows us to propagate uncertainties from the raw data to community labels. We use the model evidence to automatically determine the number of communities and show that we can recover communities from simulated data even when the number of observations is small. We apply our approach to daily returns of the constituents of the S\&P 100 index to identify communities of stocks with similar behaviour.
Anisotropic light-shift and magic-polarization of the intercombination line of Dysprosium atoms in a far-detuned dipole trap
Creators: name: Chalopin, Thomas
name: Makhalov, Vasiliy
name: Bouazza, Chayma
name: Evrard, Alexandre
name: Barker, Adam
name: Lepers, Maxence
name: Wyart, Jean-François
name: Dulieu, Olivier
name: Dalibard, Jean
name: Lopes, Raphael
name: Nascimbene, Sylvain
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Atomic Physics (physics.atom-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We characterize the anisotropic differential ac-Stark shift for the Dy $626$ nm intercombination transition, induced in a far-detuned $1070$ nm optical dipole trap, and observe the existence of a "magic polarization" for which the polarizabilities of the ground and excited states are equal. From our measurements we extract both the scalar and tensorial components of the dynamic dipole polarizability for the excited state, $α_E^\text{s} = 188 (12)\,α_\text{0}$ and $α_E^\text{t} = 34 (12)\,α_\text{0}$, respectively, where $α_\text{0}$ is the atomic unit for the electric polarizability. We also provide a theoretical model allowing us to predict the excited state polarizability and find qualitative agreement with our observations. Furthermore, we utilize our findings to optimize the efficiency of Doppler cooling of a trapped gas, by controlling the sign and magnitude of the inhomogeneous broadening of the optical transition. The resulting initial gain of the collisional rate allows us, after forced evaporation cooling, to produce a quasi-pure Bose-Einstein condensate of $^{162}$Dy with $3\times 10^4$ atoms.
description: 6 pages, 4 figures
Strix ulula Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Strigiformes
Strigidae
Strix
Strix ulula

description: Strix ulula [spec. nov.]
S. capite laevi, corpore supra fusco albo maculato, rectricibus fasciis albis. Fn. svec. 52.
Ulula. Gesn. av. 773. Aldr. ornith. l. 8. c. 6. Will. ornith. 68. t. 13. Raj. av. 26. n. 4.
Habitat in Europa.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 93, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Additional file 4: of Pharmacological inhibition of LSD1 activity blocks REST-dependent medulloblastoma cell migration
Creators: name: Callegari, Keri
name: Maegawa, Shinji
name: Bravo-Alegria, Javiera
name: Gopalakrishnan, Vidya
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Hematology
subject: 60506 Virology

description: A, MTT assay of 24 h and 48 h time points with three different LSD1 inhibitors (Tranylcypromine, GSKLSD1, and GSK2789552) in Daoy and UW228 cells showing no dose-response in response to up to 100 uM drug dosage. B, MTT assay of 24 h and 48 h timepoints with three different LSD1 inhibitors (Tranylcypromine, GSKLSD1, and GSK2789552) in isogenic high-REST counterparts, Daoy-REST and UW228-REST cells, showing no dose-response in response to up to 100 uM drug dosage. (PDF 1067 kb)
Recursive axiomatizations for representable posets
Creators: name: Egrot, Rob
Publisher: name: arXiv
Year: 2018
Subjects: subject: Logic (math.LO)
subject: FOS: Mathematics
subject: 03C98, 06A11

description: We use model theoretic techniques to construct explicit first-order axiomatizations for the classes of posets that can be represented as systems of sets, where the order relation is given by inclusion, and existing meets and joins of specified countable cardinalities correspond to intersections and unions respectively.
description: Minor edits
Supernovae, Pulsars and Gamma-Ray Bursts: A Unified Picture
Creators: name: Cen, Renyue
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: A scenario is proposed that explains both the observed high pulsar velocities and extragalactic gamma-ray bursts (GRBs). The model involves an ultra- relativistic jet from a supernova (SN), that produces a GRB and its afterglow, whose characteristics are similar to an isotropic fireball GRB perhaps with some differences at late times in the afterglow once some significant transverse diffusion has occurred. The time scales and many other properties of GRBs and their afterglows in this model are consistent with observations. GRBs in this model have special intrinsic properties, that can either falsify or prove this model unambiguously by observations. The most direct proof is the detection of a SN about the same time as the luminous GRB event. Most GRBs and SNe are expected occur at moderate redshift ($z\sim 1-3$), if they follow the observed universal star formation history, as implied in this model. Searching for GRB/SN associations is a challenge, because majority of the SNe will be faint. Some additional, dramatic observable consequences are predicted, which can also be utilized to test the model.
description: ApJ Letters in press, 4 emulateapj pages
title: ADCO, Cartulaire du prieuré Notre-Dame de Bonvaux, dépendant du Val-des-Ecoliers (XVe siècle), Dijon, Cart. 228 (27 H), 68 folios, 109 actes (1211-1356), f. 0017
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2011
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi

description: Cartulaire du prieuré Notre-Dame de Bonvaux, dépendant du Val-des-Ecoliers (XVe siècle), Dijon, Archives départementales de la Côte-d'Or, Cart. 228 (27 H), 68 folios, 109 actes (1211-1356). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire du prieuré Notre-Dame de Bonvaux, dépendant du Val-des-Ecoliers (XVe siècle), Dijon, Archives départementales de la Côte-d'Or, Cart. 228 (27 H), 68 folios, 109 actes (1211-1356), f. 0017, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: Dijon
description: Provenance: http://www.wikidata.org/entity/Q7003
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb15250518p
description: Provenance: http://www.idref.fr/02643413X/id
description: Provenance: https://www.geonames.org/6453767
On the maximum of conditioned random walks and tightness for pinning models
Creators: name: Caravenna, Francesco
Publisher: name: arXiv
Year: 2018
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 82B41, 60K35, 60B10

description: We consider real random walks with finite variance. We prove an optimal integrability result for the diffusively rescaled maximum, when the walk or its bridge is conditioned to stay positive, or to avoid zero. As an application, we prove tightness under diffusive rescaling for general pinning and wetting models based on random walks.
description: 13 pages. Changed title, improved result (Theorem 3.2), fixed typos. Final version published in ECP
Strix passerina Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Strigiformes
Strigidae
Strix
Strix passerina

description: Strix passerina [spec. nov.]
S. capite laevi, remigibus albis: maculis qvinqve ordinum. Fn. Svec. 53.
Noctua minima. Gesn. av. 620. Aldr. ornith. l. 8. c. 7. Will. ornith. 69. t. 13. Raj. av. 26. n. 6. Alb. av. 2. p. 12. t. 12. Frisch. av. t. 100.
Habitat in Europa.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 93, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
MOESM1 of Gene Expression Profiles in Alveolar Macrophages Induced by Lipopolysaccharide in Humans
Creators: name: Reynier, Frederic
name: Vos, Alex De
name: Hoogerwerf, Jacobien
name: Bresser, Paul
name: Zee, Jaring Van Der
name: Malick Paye
name: Pachot, Alexandre
name: Mougin, Bruno
name: Poll, Tom Van Der
Publisher: name: figshare
Year: 2012
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Supplementary material, approximately 823 KB.
title: A ladder type iron(II) coordination polymer with cooperative spin transition
Creators: name: Bauer, Wolfgang
name: Schlamp, Stephan
name: Weber, Birgit
Publisher: name: University of Bayreuth
Year: 2012
Subjects: subject: 540

description: Ladder type 1D coordination polymers were synthesised with the aim to improve the spin crossover properties of the iron(ii) complexes following the concepts of crystal engineering. A wide hysteresis loop (34 K) was observed if rigid linkers were used. The first X-ray structure for a 1D iron(ii) ladder is reported.
Environmental effects on the structure of the Dwarf Spheroidal Galaxies
Creators: name: Bellazzini, M.
name: Pecci, F. Fusi
name: Ferraro, F. R.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The central surface brightness ($μ_V(0)$) of the dwarf spheroidal satellites of our own Galaxy is found to correlate with their distance from the Galactic Center ($R_{GC}$). This observational evidence suggests that environmental effects could strongly influence their structure. This suggestion is further supported by a clear-cut bivariate correlation linking $μ_V(0)$ to a linear combination of $M_V$, the absolute integrated magnitude, and $R_{GC}$, which seems to be shared also by the M31 spheroidals. Possible implications for the Fundamental Plane of elliptical galaxies and Dark Matter content of dwarf spheroidals are also briefly discussed.
description: 14 pages, plain TEX, 4 figures soon available via ftp://boas3.bo.astro .it bap/files/ , get bap95-34fig*.ps or http://www.bo.astro.it/ or upon request at bellazzini@astbo3.bo.astro.it --accepted by MNRAS-Letters