title: ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð¾Ð¿ÑÑ Ð¾Ð»ÐµÐ²Ð¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð½Ð¾Ð²Ð¾Ð³Ð¾ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ñ Ð¸Ð· ÐºÐ»Ð°ÑÑÐ° Ð½Ð¸ÑÑÐ¾Ð·Ð¾Ð°Ð»ÐºÐ¸Ð»Ð¼Ð¾ÑÐµÐ²Ð¸Ð½ Ð½Ð° Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð°ÑÑÐ¸ÑÐ½Ð¾Ð¹ Ð¾Ð¿ÑÑ Ð¾Ð»Ð¸ Ð­ÑÐ»Ð¸Ñ Ð° Ñ Ð¼ÑÑÐµÐ¹
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Investigation of the antitumor activity of a new compound from the class of nitrosoalkylureas on the model of Ehrlich's ascitic tumor of mice
Creators: name: ÐÐ¸Ð½ÑÐµÐ½ÐºÐ¾, Ð®Ð»Ð¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: ÐºÐ°ÑÑÐ¸Ð½Ð¾Ð¼Ð° Ð­ÑÐ»Ð¸Ñ Ð°
Ð¿ÐµÑÐ¸ÑÐ¾Ð½ÐµÐ°Ð»ÑÐ½ÑÐ¹ ÐºÐ°Ð½ÑÐµÑÐ¾Ð¼Ð°ÑÐ¾Ð·
ÐºÐ»Ð°ÑÑ Ð½Ð¸ÑÑÐ¾Ð·Ð¾Ð°Ð»ÐºÐ¸Ð»Ð¼Ð¾ÑÐµÐ²Ð¸Ð½
Ð¿Ð°ÐºÐ»Ð¸ÑÐ°ÐºÑÐµÐ»
Ð¸Ð½ÑÑÐ·Ð¸Ñ
Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð¾Ðµ Ð¾Ð±ÐµÑÐ¿ÐµÑÐµÐ½Ð¸Ðµ Pass online
Erlich carcinoma
peritoneal carcinomatosis
nitrosoalkylureas
paclitaxel
infusion
pass Online software

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description: On 65 pages, 13 figures, 13 tables.The purpose of the research work is to study the antitumor activity of "compound 710", a derivative of a new group of antitumor compounds from the class of nitrosoalkylureas, on the model of Ehrlich's ascites carcinoma in BALB/c mice. The tasks of the study: - to evaluate the antitumor activity of compound 710 using the model of intraperitoneal infusion in BALB/c mice with a transplanted Ehrlich tumo- to conduct a comparative analysis of the drug paclitaxel, used in intraperitoneal chemotherapy, and a new domestic compound from the class of nitrosoalkylureas;- to use the Pass Online software to analyze the biological activity and toxicity of compound 710 and paclitaxel in BALB/c mice with a transplanted Ehrlich tumor;- to identify dangerous factors in the work process of researchers of the Federal State Budgetary Institution "National Medical Research Center of Oncology named after N.N.Petrov" of the Ministry of Health of the Russian Federation.The object of the research work is compound 710 from the class of nitrosoalkylureas, synthesized at Federal State Budgetary Institution "National Medical Research Center of Oncology named after N.N.Petrov" of the Ministry of Health of the Russian Federation. The subject of the study is the antitumor activity of compound 710 in the treatment of BALB/c mice with transplanted Ehrlich's tumor.The novelty of the work is â¢ study of the antitumor activity of a new compound 710 from the class of nitrosoalkylureas, using in the experiment a new method of intraperitoneal infusion, which is practically not used in clinical practice;â¢ a comparative analysis of the results of the experiment with the Pass Online software database to identify the antitumor activity and toxicity of a given compound 710, the possibility of expanding the Pass Online database for this tumor model in mice.Compound 710 has been shown to be effective in a BALB/c mouse model of Ehrlich's ascitic carcinoma. The data obtained using the Pass Online software confirm the antitumor effect of compound 710. This makes further clinical studies of the compound with a view to its future use in clinical practice highly relevant.