cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Ultrasound scan characterisation of ovarian masses
Creators: name: Sayasneh, Ahmad
Publisher: name: Imperial College London
Year: 2014

description: Background: Different ultrasound based models, rules and descriptors are used to characterise ovarian masses. LR2 is a logistic regression model with six variables to assess the preoperative risk of ovarian malignancy. Simple rules (SR) are ten features of an adnexal mass that may be identified using ultrasonography. Simple descriptors (SD) are five ultrasound characteristics and one based on age and serum CA 125 that enable an intuitive classification of adnexal masses. Objectives: The main aim was to assess the performance of the conventional (Risk of Malignancy Index RMI) and the IOTA (International Ovarian Tumour Analysis Group) models (LR2, SR and SD) and subjective assessment (SA) by examiners of varied ultrasound training and experience (level II). Methods: We carried out a prospective single-blinded randomised controlled trial (IOTA 4a) to investigate the referral pattern following the use of RMI and LR2. In IOTA 4b, diagnostic performance measures for LR2, RMI, SR, SD and SA were compared in a three-year multicentre prospective observational study. A prospective comparison was also carried out between LR2 and ROMA (Risk of Ovarian Malignancy Algorithm). Results: In the IOTA 4a RCT, LR2 correctly classified 100% of benign masses as low risk compared to 70% for RMI (difference of 30%. p<0.0001). In IOTA 4b study, a higher AUC for LR2 compared to RMI was observed in premenopausal women (0.93 and 0.83 respectively. p=0.05). Overall the combination of SD and SR were able to characterise 89% of masses (DOR of 348). Subjective assessment by level II ultrasound examiners had a DOR of 85.56. In relation to ROMA, the AUC of LR2 for discriminating between benign and malignant adnexal masses (0.952) was higher than that of ROMA (0.893) (p=0.0004). Conclusion: The overall test performance of IOTA LR2, SR and SD was maintained in the hands of examiners with varying levels of training and experience. This performance was generally better than the RMI. LR2 showed a better diagnostic performance than ROMA.
Constraints on CDM theories from observations of massive, X-ray luminous clusters of galaxies at high redshift
Creators: name: Luppino, G. A.
name: Gioia, I. M.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: During the course of a gravitational lensing survey of distant, X-ray selected, EMSS clusters of galaxies, we have studied 6 X-ray luminous (Lx > 5x10^44 h_{50}^{-2} erg s^{-1}) clusters at redshifts exceeding z=0.5. All of these clusters are apparently massive. In addition to their high X-ray luminosity, two of the clusters at z~0.6 exhibit gravitationally lensed arcs. Furthermore, the highest redshift cluster in our sample, MS1054-0321 at z=0.826, is both extremely X-ray luminous (L[0.3-3.5 keV]=9.3x10^{44} h_{50}^{-2} erg s^{-1}), and exceedingly rich with an optical richness comparable to an Abell Richness Class 4 cluster. In this {\it Letter}, we discuss the cosmological implications of the very existence of these clusters for hierarchical stucture formation theories such as standard Ω=1 CDM, hybrid Ω=1 C+HDM, and flat, low-density Λ+CDM models.
description: 11 pages, compressed and uuencoded postscript. 3 postscript images can be found in ftp://hubble.ifa.hawaii.edu/pub/ger/*.ps.Z To appear in ApJ Letters.
Relative chaos in gravitating systems with massive centre
Creators: name: El-Zant, Amr
name: Gurzadyan, Vahe
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: A geometric method, using the Ricci (or mean) curvature of the Lagrangian (configuration) manifold, is used to study the relative instability of evolving $N$-body gravitating systems with massive centres. The performed numerical experiments show that the Ricci curvature decreases with the increase in central concentration, thus indicating an increasing instability for systems with massive centre --- either in the form of a point mass or a core formed during the evolution of single and multimass systems. Simulations of such systems do indeed suggest that they have faster gravothermal evolution than less concentrated ones.
description: To appear in Physica D (Nonlinear Sciences)
Additional file 1 of A graph-based filtering method for top-down mass spectral identification
Creators: name: Runmin Yang
name: Daming Zhu
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology

description: A summary of parameters and their default values of the SGM filtering algorithm. (PDF 28 kb)
Quantum diffusion beyond slow-roll: implications for primordial black-hole production
Creators: name: Ezquiaga, Jose María
name: García-Bellido, Juan
Publisher: name: arXiv
Year: 2018
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Primordial black-holes (PBH) can be produced in single-field models of inflation with a quasi-inflection point in the potential. In these models, a large production of PBHs requires a deviation from the slow-roll (SR) trajectory. In turn, this SR violation can produce an exponential growth of quantum fluctuations. We study the back-reaction of these quantum modes on the inflationary dynamics using stochastic inflation in the Hamilton-Jacobi formalism. We develop a methodology to solve quantum diffusion beyond SR in terms of the statistical moments of the probability distribution. We apply these techniques to a toy model potential with a quasi-inflection point. We find that there is an enhancement of the power spectrum due to the dominance of the stochastic noise in the phase beyond SR. Moreover, non-Gaussian corrections become as well relevant with a large positive kurtosis. Altogether, this produces a significant boost of PBH production. We discuss how our results extend to other single-field models with similar dynamics. We conclude that the abundance of PBHs in this class of models should be revisited including quantum diffusion.
description: 17+7 pages, 5 figures. Matches JCAP version
Behaviour and design of prestressed steel structures
Creators: name: Gosaye Fida Kaba, Jonathan
Publisher: name: Imperial College London
Year: 2015

description: The behaviour and design of prestressed steel structures, with an emphasis on trussed arches, are examined in this thesis. For long-span structural systems, where self-weight becomes an increasingly dominant component of the design loading, significant material savings can be achieved through the use of high tensile strength steel cables in conjunction with conventional steelwork. Further benefits can be achieved by prestressing the cables. In the system currently being investigated, the prestressed cables, which are housed within the bottom chord of tubular arched trusses, apply a compressive force to the chord members, which is opposite in nature to the resultant forces arising from the externally applied gravity loads. The stability of the trussed elements under prestress and the load--deformation response of the prestressed elements to the subsequent application of tensile loading are examined analytically, numerically and experimentally, with good correlation achieved between the three approaches. The benefits of prestressing, in terms of increased member strength and stiffness, are demonstrated, and optimal prestress levels are investigated. In instances of load reversal (e.g. due to wind uplift) in trusses without horizontal end anchorage that would allow catenary forces to develop, the presence of prestress can become detrimental. To examine this, a total of eight pin-ended cable-in-tube systems, featuring both non-grouted and grouted members, were tested in compression. Increasing initial prestress levels was found to reduce the capacity of the system in compression, but initial prestress was shown to be less detrimental than externally applied compressive loading of the same magnitude, due to the absence of second order bending moments. Finite element models were developed and, following accurate replication of test results, were used to generate parametric results for a range of member slendernesses and prestress levels. The test and FE results were compared against capacity predictions based on a proposed modified Perry-Robertson design method. Consistent, accurate and generally safe-side predictions were achieved. Following the examination of behaviour of individual prestressed elements within the truss, a series of analytical and numerical models of the full arched truss system were developed to investigate its global structural behaviour. Parametric studies revealed that the horizontal end boundary conditions, prestress level, truss depth and diagonal member arrangements were the key parameters influencing the stiffness, load bearing capacity and failure mode of the structure.
Cycle Consistent Adversarial Denoising Network for Multiphase Coronary CT Angiography
Creators: name: Kang, Eunhee
name: Koo, Hyun Jung
name: Yang, Dong Hyun
name: Seo, Joon Bum
name: Ye, Jong Chul
Publisher: name: arXiv
Year: 2018
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Artificial Intelligence (cs.AI)
subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: In coronary CT angiography, a series of CT images are taken at different levels of radiation dose during the examination. Although this reduces the total radiation dose, the image quality during the low-dose phases is significantly degraded. To address this problem, here we propose a novel semi-supervised learning technique that can remove the noises of the CT images obtained in the low-dose phases by learning from the CT images in the routine dose phases. Although a supervised learning approach is not possible due to the differences in the underlying heart structure in two phases, the images in the two phases are closely related so that we propose a cycle-consistent adversarial denoising network to learn the non-degenerate mapping between the low and high dose cardiac phases. Experimental results showed that the proposed method effectively reduces the noise in the low-dose CT image while the preserving detailed texture and edge information. Moreover, thanks to the cyclic consistency and identity loss, the proposed network does not create any artificial features that are not present in the input images. Visual grading and quality evaluation also confirm that the proposed method provides significant improvement in diagnostic quality.
description: This work is accepted in Medical Physics
Renal denervation in heart failure with preserved ejection fraction
Creators: name: Patel, Hitesh Chandrakant
Publisher: name: Imperial College London
Year: 2016

description: There are no treatments proven to significantly reduce heart failure hospitalisations or mortality in patients with heart failure with preserved ejection fraction (HFpEF). Activity of the sympathetic nervous system (SNS) is elevated in heart failure regardless of ejection fraction and may be an important target in HFpEF. Renal denervation (RDT) is a percutaneous technique that seeks to attenuate SNS activity. The aim of this thesis was to investigate the role of RDT in patients with HFpEF. A randomised (2:1) open-controlled trial with blinded endpoint analysis was planned. 10 228 patients were screened for the Renal DenervaTion in heart failure with Preserved Ejection Fraction trial (RDT-PEF), and ultimately 25 were randomised (17 received RDT and 8 were allocated to the open control arm). The primary endpoint was an improvement in a minimum of three out of the following six surrogate endpoints: Minnesota Living with Heart Failure questionnaire score, peak oxygen uptake on exercise, B-type natriuretic peptide, E/e‟ from echocardiography, left atrial volume from cardiac magnetic resonance imaging (CMR) and left ventricular mass from (CMR). The primary endpoint was not met but the study was underpowered. On post-hoc analysis there was an improvement in a composite score of all six endpoint in the RDT arm compared to the control arm at three months but this did not persist to 12 months. The study satisfied its safety endpoints. However, two patients required balloon angioplasty during the RDT procedure for significant renal artery spasm/oedema. RDT had no effect on blood pressure, renal function, vascular function, renin-angiotensin system or SNS activity. In summary, this thesis has shown that HFpEF is not as prevalent as reported. RDT did not improve quality of life, exercise function, biomarkers and left heart remodelling in HFpEF. The procedure was safe though not without complications in patients with HFpEF.
Additional file 6: of Role of anatomical sites and correlated risk factors on the survival of orthodontic miniscrew implants: a systematic review and meta-analysis
Creators: name: Mohammed, Hisham
name: Wafaie, Khaled
name: Mumen Rizk
name: Almuzian, Mohammed
name: Sosly, Rami
name: Bearn, David
Publisher: name: figshare
Year: 2018
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy
subject: Hematology

description: Figure S1. Sensitivity analyses. (PDF 530 kb)
A novel architecture for secure database processing in cloud computing
Creators: name: Chen, Hung-Kwan
Publisher: name: Imperial College London
Year: 2016

description: Security, particularly data privacy, is one of the biggest barriers to the adoption of Database-as-a-Service (DBaaS) in Cloud Computing. Recent security breaches demonstrate that a more powerful protection mechanism is needed to protect data confidentiality from any honest-but-curious administrator. Typical prior effort on addressing this security problem is either prohibitively slow or highly restrictive in operation. In this thesis, a novel cloud system architecture CypherDB, which makes use of a secure processor, is proposed to protect the confidentiality of outsourced database processing. To achieve this, a framework is developed to use these secure processors in the cloud for secure database processing. This framework allows distributed and parallel processing of the encrypted data and exhibits virtualization features in Cloud Computing. The CypherDB architecture also relies on two major components to protect the privacy of an outsourced database against any honest-but-curious administrator of high performance. Firstly, a novel database encryption scheme is developed to protect the outsourced database which can be executed under a CypherDB secure processor with high performance. Our proposed scheme makes use of custom instructions to hide the encryption latency from the program execution. This scheme is extensively validated through an integration with SQLite, a practical database application program. Secondly, a novel secure processor architecture is also developed to provide architectural support to our proposed database encryption scheme and efficient protection mechanism to secure all intermediate data generated on-the-fly during query execution. The efficiency, robustness and the cost of our novel processor architecture are validated and evaluated through extensive simulations and implementation on a FPGA platform. A fully-functional Field-Programmable Gate Array (FPGA) implementation of our CypherDB secure processor and simulation studies demonstrate that our proposed architecture is cost-effective and of high performance. Our experiment of running the TPC-H database benchmark on SQLite demonstrates 10 to 14 percent performance overhead on average. The security components in CypherDB consume about 21K Logic Elements and 54 Block RAMs on the FPGA. The modification of SQLite only consists of 208 lines of code (LOC).
Dehn surgery and Heegaard Floer homology
Creators: name: Gainullin, Fjodor
Publisher: name: Imperial College London
Year: 2016

description: This thesis presents some new results on Dehn surgery. The overarching theme of the thesis is to find restrictions on obtaining a 3-manifold by a Dehn surgery on a knot in another 3-manifold (although we also find new examples in chapter 5) and most of these restrictions are obtained by exploring the consequences of the mapping cone formula in Heegaard Floer homology. In particular, we show that only finitely many alternating knots can yield a given 3-manifold by Dehn surgery and confirm the knot complement conjecture for many classes of knots.
Untitled ItemTeaching laboratory best practice considerations for Covid19
Creators: name: Dickie, Ian A.
name: Heinemann, Jack A
name: Galilee, Craig
name: Lauren-Manuera, Nicole
name: Meisrimler, Claudia-Nicole
name: Remus-Emsermann, Mitja
name: Stott, Matthew
Publisher: name: figshare
Year: 2021
Subjects: Uncategorized

description: The purpose of this document is to help collate information about Covid19 spreadprevention, and make recommendations for best practice in teaching laboratories.The focus is specifically on teaching laboratories. Nonetheless, most elements in thisdocument are also relevant to research laboratories, which are addressed in theappendix. We note that while this document is specific to the SARS-Cov2 virus andCovid19, many elements of best-practice during an epidemic or pandemic situationare also good general practice. The same practices that reduce Covid-19 will alsogreatly reduce flu, the common cold, and other illnesses in students and staff.
Ricinus communis Linnaeus 1753
Creators: name: Jarvis, Charlie
Publisher: name: Linnaean Society of London in association with the Natural History Museum
Year: 2007
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Malpighiales
Euphorbiaceae
Ricinus
Ricinus communis

description: Ricinus communis Linnaeus, Species Plantarum 2: 1007. 1753.
"Habitat in India utraque, Africa, Europa australi." RCN: 7298.
Lectotype (Seegeler, Oil Pl. Ethiopia: 212. 1983): Herb. Clifford: 450, Ricinus 1 (BM-000647441).
Generitype of Ricinus Linnaeus.
Current name: Ricinus communis L. (Euphorbiaceae).
Note: Fawcett & Rendle (Fl. Jamaica 4: 307. 1920) indicated 1142.1 (LINN) as type but this was a post-1753 addition to the collection, from Brander, and not original material for the name.
description: Published as part of Jarvis, Charlie, 2007, Chapter 7: Linnaean Plant Names and their Types (part R), pp. 785-805 in Order out of Chaos. Linnaean Plant Types and their Types, London :Linnaean Society of London in association with the Natural History Museum on page 796, DOI: 10.5281/zenodo.291971
G-inflation: From the intermediate, logamediate and exponential models
Creators: name: Herrera, Ramon
name: Videla, Nelson
name: Olivares, Marco
Publisher: name: arXiv
Year: 2018
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The intermediate, logamediate and exponential inflationary models in the context of Galileon inflation or G-inflation are studied. By assuming a coupling of the form $G(ϕ,X)\proptoϕ^ν\,X^{n}$ in the action, we obtain different analytical solutions from the background cosmological perturbations assuming the slow-roll approximation. General conditions required for these models of G-inflation to be realizable are determined and discussed. In general, we analyze the condition of inflation and also we use recent astronomical and cosmological observations for constraining the parameters appearing in these G-inflationary models.
description: 27 pages and 2 figures. Non-Gaussianities added, accepted by EPJC
The Ages of Elliptical Galaxies in a Merger Model
Creators: name: Kauffmann, Guinevere
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The tightness of the observed colour-magnitude and Mg$_{2}$- velocity dispersion relations for elliptical galaxies has often been cited as an argument against a picture in which ellipticals form by the merging of spiral disks. A common view is that merging would mix together stars of disparate ages and produce a large scatter in these relations. Here I use semi-analytic models of galaxy formation to derive the distribution of the mean ages, colours and metallicities of the stars in elliptical galaxies formed by mergers in a flat CDM universe. It is seen that most of the stars in ellipticals form at relatively high redshift (z > 1.9) and that the predicted scatter in the colour-magnitude and Mg_2 - sigma relations falls within observational bounds. I conclude that the apparent homogeneity in the properties of the stellar populations of ellipticals is not inconsistent with a merger scenario for the origin of these systems.
description: latex file, figures available upon request
The Generic Degree of Autonomy
Creators: name: Shankar, Shiva
name: Rocha, Paula
Publisher: name: arXiv
Year: 2018
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics
subject: 39A14, 93B25, 13P25

description: This paper calculates the degree of autonomy of a generic autonomous n-D system given by the kernel of a partial difference operator. The calculation implies that attaching a generic controller to a non-autonomous system, results in a controlled system whose degree of autonomy is the maximum possible. Thus a generic controller is maximally efficient with respect to the criterion of maximising degree of autonomy. The term generic here refers to an open (dense) subset of the set of all n-D systems with the Zariski topology.
description: This arxiv version corrects errors in the published version of the paper (SIAM Journal on Applied Algebra Geometry, 2(3), 410-427, 2018), where an error in Theorem 3.1 propagated to the statements of Theorems 3.2, 4.1 and 4.2. These corrections will also appear as a Corrigendum
Nonlinear analysis of composite shells with application to glass structures
Creators: name: Liang, Yating
Publisher: name: Imperial College London
Year: 2015

description: Laminated glass is a special composite material, which is characterised by an alternating stiff/soft lay-up owing to the significant stiffness mismatch between glass and PVB. This work is motivated by the need for an efficient and accurate nonlinear model for the analysis of laminated glass structures, which describes well the through-thickness variation of displacement fields and the transverse shear strains and enables large displacement analysis. An efficient lamination model is proposed for the analysis of laminated composites with an alternating stiff/soft lay-up, where the zigzag variation of planar displacements is taken into account by adding to the Reissner-Mindlin formulation a specific set of zigzag functions. Furthermore, a piecewise linear through-thickness distribution of the material transverse shear strain is assumed, which agrees well with the real distribution, yet it avoids layer coupling by not imposing continuity constraints on transverse shear stresses. Local formulations of curved multi-layer shell elements are established employing the proposed lamination model, which are framed within local co-rotational systems to allow large displacement analysis for small-strain problems. In order to eliminate the locking phenomenon for the shell elements, an assumed strain method is employed and improved, which readily addresses shear locking, membrane locking, and distortion locking for each constitutive layer. Furthermore, a local shell system is proposed for the direct definition of the additional zigzag displacement fields and associated parameters, which allows the additional displacement variables to be coupled directly between adjacent elements without being subject to the large displacement co-rotational transformations. The developed multi-layer shell elements are employed in this work for typical laminated glass problems, including double glazing systems for which a novel volume-pressure control algorithm is proposed. Several case studies are finally presented to illustrate the effectiveness and efficiency of the proposed modelling approach for the nonlinear analysis of glass structures.
TWO-POINT ANGULAR CORRELATION FUNCTION FOR THE GREEN BANK 4.85 GHZ SKY SURVEY
Creators: name: Kooiman, Brian L.
name: Burns, Jack O.
name: Klypin, Anatoly A.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: This paper presents an angular correlation analysis of the Green Bank 4.85 GHz radio catalog (Gregory \& Condon 1991) of 54,579 sources (S \gsim 25 mJy). The Green Bank catalog is found to be complete to S $\geq$ 35 mJy over 20$^{\circ} \leq δ< 74^{\circ}$, 0$^h \leq α< 24^h$, and Galactic latitude $|b| \geq 10^{\circ}$. The 2-point angular correlation function shows evidence for the clustering of radio sources, with a power-law distribution consistent with a slope $γ= -0.8$. This may well provide the $first$ detection of an angular correlation in a large area, complete deep radio survey.
description: 14 pages, compressed, uuencoded postscript. Plots and text: anonymous ftp://charon.nmsu.edu/pub/PAPERS/aklypin, apj.uu and apjfigs.uu
Probabilistic Fault-Tolerant Universal Quantum Computation and Sampling Problems in Continuous Variables
Creators: name: Douce, Tom
name: Markham, Damian
name: Kashefi, Elham
name: van Loock, Peter
name: Ferrini, Giulia
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Continuous-Variable (CV) devices are a promising platform for demonstrating large-scale quantum information protocols. In this framework, we define a general quantum computational model based on a CV hardware. It consists of vacuum input states, a finite set of gates - including non-Gaussian elements - and homodyne detection. We show that this model incorporates encodings sufficient for probabilistic fault-tolerant universal quantum computing. Furthermore, we show that this model can be adapted to yield sampling problems that cannot be simulated efficiently with a classical computer, unless the polynomial hierarchy collapses. This allows us to provide a simple paradigm for short-term experiments to probe quantum advantage relying on Gaussian states, homodyne detection and some form of non-Gaussian evolution. We finally address the recently introduced model of Instantaneous Quantum Computing in CV, and prove that the hardness statement is robust with respect to some experimentally relevant simplifications in the definition of that model.
description: Corrected a mistake in v1 concerning squeezing amplification
Additional file 2 of Clinical and molecular factors that impact the efficacy of first-line crizotinib in ROS1-rearranged non-small-cell lung cancer: a large multicenter retrospective study
Creators: name: Zhang, Yongchang
name: Zhang, Xiangyu
name: Zhang, Ruiguang
name: Xu, Qinqin
name: Yang, Haiyan
name: Lizaso, Analyn
name: Xu, Chunwei
name: Liu, Jun
name: Wang, Wenxian
name: Ou, Sai-Hong Ignatius
name: Zhang, Jiexia
name: Song, Zhengbo
name: Yang, Nong
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Additional file 2:. Table S1. List of genes included in the 168-gene panel (Lung Plasma, Burning Rock Biotech). Table S2. Distribution of ROS1 fusions among the 220 patients with single ROS1 fusion and 15 patients with non-reciprocal/reciprocal ROS1 translocations. Table S3. Detailed breakpoint information for the non-reciprocal/reciprocal ROS1 translocations detected in the cohort. Table S4. Response to crizotinib of ROS1-rearranged lung cancers. Table S5. Clinicopathologic characteristics of the patients with single ROS1 fusions and non-reciprocal/reciprocal ROS1 translocations. Table S6. Treatment outcomes on first-line crizotinib therapy of the 159 patients with single ROS1 fusion grouped according to ROS1 fusion partners. Table S7. Detailed clinicopathologic characteristics and clinical outcomes of the 13 patients with uncommon non-CD74 ROS1 fusions. Table S8. Detailed clinicopathologic characteristics and clinical outcomes of the patients with non-reciprocal/reciprocal ROS1 translocations. Table S9. Comparison of concurrent mutation according to ROS1 mutation. Table S10. Cox regression analysis for progression-free survival (n=168). Table S11. Detailed clinicopathological characteristics and clinical outcomes of the 9 patients with concomitant driver mutations. Table S12. Detailed clinicopathological characteristics and clinical outcomes of the 8 patients with concomitant brain and non-brain progression on first-line crizotinib therapy. Table S13. Clinicopathological characteristics of the patients with brain progression and non-brain progression on first-line crizotinib therapy
Additional file 3: of The unintended consequences of combining equity measures with performance-based financing in Burkina Faso
Creators: name: Turcotte-Tremblay, Anne-Marie
name: Allegri, Manuela De
name: Idriss Gali-Gali
name: ValĂŠry Ridde
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Average number of new consultations for patients classified as indigents or non-indigents seen in curative care for healthcare centres in PBF2 and PBF3 across eight districts. (DOCX 149 kb)
Assessment of nanomedicine preparations as potential therapies for pulmonary arterial hypertension
Creators: name: Mohamed, Nura
Publisher: name: Imperial College London
Year: 2016

description: Pulmonary arterial hypertension (PAH) is an aggressive disease with poor prognosis, no available cure and with survival rates of 2-5 years after diagnosis. However, there are drugs available, which work by enhancing dilator pathways or blocking constrictors that limit progression of the disease; Unfortunately these drugs have the critical limitation of dilator effects in the systemic circulation and are associated with class specific side effects. One way of overcoming systemic (and other) side effects is to employ a nanomedicine approach where drugs can be encapsulated in a nano-sized (≈100nm) carrier molecule and directed specially to the diseased vessels of the lung. Nanoparticles used in the medical field are classified to being organic or inorganic. In my PhD I investigated the effects of two nanomedicine formulations in biological systems one organic and one inorganic. Firstly I prepared an iron (Fe) containing metal organic framework (MOF), MIL-89 and it is PEGylated form (MIL-89 PEG).. MIL-89 preparations confirmed to the predicted structure and were non-toxic in vitro and in vivo with some potential anti-inflammatory effects at high concentrations. Unfortunately loading MIL-89 with drug and assessing effects in relevant systems was beyond the scope of my PhD thesis, but future development of MIL-89 in a PAH setting is discussed throughout. Secondly I studied the chemical and biological effects of a novel NO-releasing nanomedicine formulation consisting of nitrated polymers (NO-NP). NO-NP released NO, is relatively non-toxic, inhibited some aspects of inflammation and was an effective vasodilator with selectively towards pulmonary artery over systemic vessels (aorta). The data in my thesis are consistent with the idea that a nanomedicine approach is achievable in PAH and my personal view is that in the future PAH drugs will be delivered as targeted therapies with the potential of converting PAH into a chronic drug-managed condition.
MgTa2N3: A new reference Dirac semimetal
Creators: name: Wu, QuanSheng
name: Piveteau, Christophe
name: Song, Zhida
name: Yazyev, Oleg V.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We present a prediction of the Dirac semimetal (DSM) phase in MgTa2N3 based on first-principles calculations and symmetry analysis. In this material, the Fermi level is located exactly at the Dirac point without additional Fermi surface pockets. The band inversion associated with the Dirac cone involves the d orbitals of two structurally inequivalent Ta atoms with octahedral and trigonal prismatic coordination spheres. We further show that the lattice symmetry breaking can realize topological phase transitions from the DSM phase to a triple nodal point semimetal, Weyl semimetal or topological insulator. The topologically protected surface states and the non-protected Fermi arc surface states are also studied.
description: 4 figures, 11 pages
Towards a Maturity Assessment Framework for MBSE Adoption: Results from a Meta-Synthesis - Supplementary Material
Creators: name: Henoeckl, Tobias
name: Verbruggen, Charlotte
name: Bork, Dominik
Publisher: name: Zenodo
Year: 2025

description: This repository contains the suplementary material for the paper:

Henoeckl, T., Verbruggen, C., Bork, D. (2025). Towards a Maturity Assessment Framework for MBSE Adoption: Results from a Meta-Synthesis. Accepted at EMMSAD'25

 

The file Level1_InitialPreparation.jpg is a large image depicting a detailed version of Level 1 of the maturity assessment framework.

The file Level2_PlanningAndStructure.jpg is a large image depicting a detailed version of Level 2 of the maturity assessment framework.

The file Level3_PilotProject.jpg is a large image depicting a detailed version of Level 3 of the maturity assessment framework.

The file Level4_ScalingMBSEadoption.jpg is a large image depicting a detailed version of Level 4 of the maturity assessment framework.

The file TowardsaMaturityAssessmentFrameworkForMBSEadoption_ChallengesPitfallsAndBestPractices.pdf contains the self-assessment questionnaire to identify the maturity level of an organization in MBSE adoption, and a detailed explanation for each Challenge, Pitfall and Best Practice from the maturity assessment framework.

The file TowardsaMaturityAssessmentFrameworkForMBSEadoption_DomainExpertSurvey.pdf contains the survey that was sent to domain experts for an initial evaluation of the maturity assessment framework.
Turbulent inhomogeneous autoignition of liquid fuels
Creators: name: Gupta, Ajay
Publisher: name: Imperial College London
Year: 2016

description: Autoignition is a multi-physics phenomenon that occurs in wide-ranging engineering applications, such as diesel engines, gas turbines and jet-engine afterburners. In these applications, autoignition occurs in the presence of flow inhomogeneities and turbulence. Further, liquid fuel autoignition presents a case of chemically reacting flow where processes such as jet break-up, atomisation, droplet evaporation (interfacial heat and mass transfer), turbulent mixing and chemical reaction occur simultaneously in the presence of important flow, mixture and phase inhomogeneities. The multi-scale nature and direct coupling between these various contributing processes, present a challenging fundamental problem which cannot be understood by extrapolation from homogeneous, inhomogeneous (gaseous) and even single droplet combustion studies. This thesis presents an experimental study on autoignition of polydispersed droplets generated by single liquid jets of pure liquid n-heptane and n-pentane injected axisymmetrically from a circular nozzle into a confined turbulent hot coflow of air at atmospheric pressure. Distinct phenomena are identified concerning the emergence of various autoignition regimes --- no autoignition, random spots and continuous flame; the occurrence of these regimes depends on the reaction conditions of air temperature, air velocity, and liquid fuel injection velocity. In the random spots regime, autoignition appears in the form of well-defined localised spots occurring randomly along the length of the reactor. Optical measurements of these random spots are made from which the autoignition lengths/locations are measured and are used to infer average delay (or residence) times from injection. At higher air temperatures and lower liquid fuel injection velocities, autoignition is observed to move closer to the injector; the corresponding delay times also decrease. With increasing air velocity and hence turbulent fluctuations, autoignition moves downstream but the delay times decrease. The shorter delay times are also associated with faster evaporation of the liquid fuel. The results from this work suggest that turbulent inhomogeneous autoignition of liquid fuels cannot be directly predicted from chemical delay times from homogeneous studies and that the effects of evaporation, and turbulent mixing, as quantified by the mixture fraction and conditional scalar dissipation rate must be accounted for. The results also provide insights into the flow conditions leading up to the various observed autoignition phenomena for liquid fuels, and constitute a valuable data-set that can contribute towards developing and validating models of advanced multiphase turbulent combustion and chemically reacting flows.
The COBE Diffuse Infrared Background Experiment Search for the Cosmic Infrared Background: I. Limits and Detections
Creators: name: Hauser, M. G.
name: Arendt, R. G.
name: Kelsall, T.
name: Dwek, E.
name: Odegard, N.
name: Weiland, J. L.
name: Freudenreich, H. T.
name: Reach, W. T.
name: Silverberg, R. F.
name: Moseley, S. H.
name: Pei, Y. C.
name: Lubin, P.
name: Mather, J. C.
name: Shafer, R. A.
name: Smoot, G. F.
name: Weiss, R.
name: Wilkinson, D. T.
name: Wright, E. L.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The DIRBE on the COBE spacecraft was designed primarily to conduct systematic search for an isotropic CIB in ten photometric bands from 1.25 to 240 microns. The results of that search are presented here. Conservative limits on the CIB are obtained from the minimum observed brightness in all-sky maps at each wavelength, with the faintest limits in the DIRBE spectral range being at 3.5 microns (νI_ν< 64 nW/m^2/sr, 95% CL) and at 240 microns (νI_ν< 28 nW/m^2/sr, 95% CL). The bright foregrounds from interplanetary dust scattering and emission, stars, and interstellar dust emission are the principal impediments to the DIRBE measurements of the CIB. These foregrounds have been modeled and removed from the sky maps. Assessment of the random and systematic uncertainties in the residuals and tests for isotropy show that only the 140 and 240 microns data provide candidate detections of the CIB. The residuals and their uncertainties provide CIB upper limits more restrictive than the dark sky limits at wavelengths from 1.25 to 100 microns. No plausible solar system or Galactic source of the observed 140 and 240 microns residuals can be identified, leading to the conclusion that the CIB has been detected at levels of νI_ν= 25+-7 and 14+-3 nW/m^2/sr at 140 and 240 microns respectively. The integrated energy from 140 to 240 microns, 10.3 nW/m^2/sr, is about twice the integrated optical light from the galaxies in the Hubble Deep Field, suggesting that star formation might have been heavily enshrouded by dust at high redshift. The detections and upper limits reported here provide new constraints on models of the history of energy-releasing processes and dust production since the decoupling of the cosmic microwave background from matter.
description: 26 pages and 5 figures, accepted for publication in the Astrophyical Journal
First results on nucleon resonance photocouplings from the $γp \to π^+π^-p$ reaction
Creators: name: CLAS Collaboration
name: Golovatch, E.
name: Burkert, V. D.
name: Carman, D. S.
name: Gothe, R. W.
name: Hicks, K.
name: Ishkhanov, B. S.
name: Mokeev, V. I.
name: Pasyuk, E.
name: Adhikari, S.
name: Akbar, Z.
name: Amaryan, M. J.
name: Avakian, H.
name: Ball, J.
name: Barion, L.
name: Bashkanov, M.
name: Battaglieri, M.
name: Bedlinskiy, I.
name: Biselli, A. S.
name: Boiarinov, S.
name: Briscoe, W. J.
name: Cao, F.
name: Celentano, A.
name: Chatagnon, P.
name: Chetry, T.
name: Ciullo, G.
name: Clark, L.
name: Clary, B. A.
name: Cole, P. L.
name: Contalbrigo, M.
name: Crede, V.
name: D'Angelo, A.
name: Dashyan, N.
name: De Vita, R.
name: De Sanctis, E.
name: Defurne, M.
name: Deur, A.
name: Diehl, S.
name: Djalali, C.
name: Dugger, M.
name: Dupre, R.
name: Egiyan, H.
name: Ehrhart, M.
name: Alaoui, A. El
name: Fassi, L. El
name: Elouadrhiri, L.
name: Eugenio, P.
name: Fedotov, G.
name: Fersch, R.
name: Filippi, A.
name: Ghandilyan, Y.
name: Gilfoyle, G. P.
name: Giovanetti, K. L.
name: Girod, F. X.
name: Glazier, D. I.
name: Griffioen, K. A.
name: Guidal, M.
name: Guo, L.
name: Hafidi, K.
name: Hakobyan, H.
name: Harrison, N.
name: Hattawy, M.
name: Heddle, D.
name: Holtrop, M.
name: Ilieva, Y.
name: Ireland, D. G.
name: Isupov, E. L.
name: Jenkins, D.
name: Jo, H. S.
name: Johnston, S.
name: Joo, K.
name: Kabir, M. L.
name: Keller, D.
name: Khachatryan, G.
name: Khachatryan, M.
name: Khandaker, M.
name: Kim, W.
name: Klein, A.
name: Klein, F. J.
name: Kubarovsky, V.
name: Lanza, L.
name: Lenisa, P.
name: Livingston, K.
name: MacGregor, I. J. D.
name: Marchand, D.
name: Markov, N.
name: McKinnon, B.
name: Meyer, C. A.
name: Montgomery, R. A.
name: Movsisyan, A.
name: Camacho, C. Munoz
name: Nadel-Turonski, P.
name: Niccolai, S.
name: Niculescu, G.
name: Osipenko, M.
name: Ostrovidov, A. I.
name: Paolone, M.
name: Paremuzyan, R.
name: Park, K.
name: Pogorelko, O.
name: Price, J. W.
name: Prok, Y.
name: Protopopescu, D.
name: Ripani, M.
name: Riser, D.
name: Rizzo, A.
name: Rosner, G.
name: Sabatié, F.
name: Salgado, C.
name: Schumacher, R. A.
name: Sharabian, Y. G.
name: Skorodumina, Iu.
name: Smith, G. D.
name: Sober, D. I.
name: Sokhan, D.
name: Sparveris, N.
name: Strakovsky, I. I.
name: Strauch, S.
name: Taiuti, M.
name: Tan, J. A.
name: Tyler, N.
name: Ungaro, M.
name: Voskanyan, H.
name: Voutier, E.
name: Wang, R.
name: Wei, X.
name: Wood, M. H.
name: Zachariou, N.
name: Zhang, J.
name: Zhao, Z. W.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We report the first experimental measurements of the nine 1-fold differential cross sections for the $γp \to π^+π^-p$ reaction, obtained with the CLAS detector at Jefferson Laboratory. The measurements cover the invariant mass range of the final state hadrons from 1.6~GeV~$
title: Εισαγωγή στη γλωσσολογία σωμάτων κειμένων
Creators: name: Goutsos, Dionysios
name: Fragkaki, Georgia
Publisher: name: Kallipos, Open Academic Editions
Year: 2016
Subjects: ΣΩΜΑΤΑ ΚΕΙΜΕΝΩΝ
ΓΛΩΣΣΟΛΟΓΙΑ ΣΩΜΑΤΩΝ ΚΕΙΜΕΝΩΝ
ΨΗΦΙΑΚΕΣ ΑΝΘΡΩΠΙΣΤΙΚΕΣ ΕΠΙΣΤΗΜΕΣ
ΥΠΟΛΟΓΙΣΤΙΚΗ ΓΛΩΣΣΟΛΟΓΙΑ
Corpora
Corpus Linguistics
Digital Humanities
Computational Linguistics

description: Το βιβλίο αποτελεί μια βασική εισαγωγή στις θεωρητικές και πρακτικές πτυχές της γλωσσολογίας σωμάτων κειμένων. Τα σώματα κειμένων (corpora) είναι συλλογές μεγάλου αριθμού κειμένων, αποθηκευμένων σε ηλεκτρονική μορφή και επεξεργάσιμων με υπολογιστικά εργαλεία. Η εκτεταμένη χρήση τους κατά τις τελευταίες δεκαετίες για την ανάλυση ποικίλων γλωσσικών φαινομένων έχει καθιερώσει τη γλωσσολογία σωμάτων κειμένων (corpus linguistics) σε μια από τις βασικές μεθόδους και θεωρητικές οπτικές της γλωσσολογίας. Βασικός στόχος του βιβλίου είναι η εξοικείωση με τα είδη σωμάτων κειμένων, το σχεδιασμό και τη δημιουργία τους, καθώς και τα μεθοδολογικά εργαλεία ανάλυσής τους. Ιδιαίτερη έμφαση δίνεται στην ανάλυση λεξικών, γραμματικών και κειμενικών πτυχών της Ελληνικής και άλλων γλωσσών με τη βοήθεια σωμάτων κειμένων, ενώ παρουσιάζεται και η συμβολή τους στην ανάλυση της γλωσσικής ποικιλότητας και σε διάφορα πεδία της εφαρμοσμένης γλωσσολογίας. Ιδιαίτερο χαρακτηριστικό του βιβλίου αποτελεί η διαδραστική σύνδεση του περιεχομένου με ιστότοπους σωμάτων κειμένων (π.χ. Σώμα Ελληνικών Κειμένων) και συναφών εφαρμογών με στόχο την εμπέδωση των σχετικών εννοιών και την εξάσκηση στις πρακτικές πτυχές της γλωσσολογίας σωμάτων κειμένων. Το βιβλίο θα περιλαμβάνει, τέλος, γλωσσάρι με τους βασικούς όρους της γλωσσολογίας σωμάτων κειμένων.
Inducing IL-1β to increase vaccine efficacy
Creators: name: Russell, Ryan
Publisher: name: Imperial College London
Year: 2016

description: Despite decades of research, there is no vaccine for respiratory syncytial virus (RSV). Many different approaches have been tested, but recently, small hydrophobic gene (SH) deletion mutants have been suggested as potential vaccine candidates since such strains are attenuated in vivo. The function of the SH protein is unknown, but multiple studies suggest that SH forms a viroporin capable of acting as an ion channel. Ion flux can activate inflammasomes, complexes based on Nod-like receptors (NLR), intracellular danger sensing receptors that catalyse the cleavage of highly inflammatory cytokines including IL-1β. Since it can form an ion channel, it was hypothesised that SH plays a role in inflammasome activation. The data presented here suggest that SH prevents activation of inflammasomes, reducing production of the key cytokine IL-1β, and it is shown that IL-1β is important for the control of RSV growth in vivo. Based on this finding, it was tested whether inflammasomes would make good targets for improving vaccination, through the use of specific adjuvants. The NLRs/inflammasomes have not been fully explored as adjuvant targets. Traditional adjuvants target pathways which are less functional in vulnerable populations, including neonates, making them less efficacious in such patients. Putative inflammasome activating compounds were tested in vitro for IL-1β inducing capabilities. Those found to induce such responses were taken forward into influenza vaccine and challenge models. It was found that one adjuvant, NanoSiO2, showed particularly strong potential as a vaccine adjuvant. Moreover, this compound appears to afford protection to severe flu infection in neonates, a group traditionally challenging to immunise. The NLRs and inflammasomes may therefore represent a viable target for activation during immunisation of neonates and other vulnerable groups. This study provides evidence for the rationale of NLR/inflammasome targeting during vaccination and demonstrates two new approaches to improve vaccines for difficult pathogens and at-risk populations.
Additional file 5: of Role of anatomical sites and correlated risk factors on the survival of orthodontic miniscrew implants: a systematic review and meta-analysis
Creators: name: Mohammed, Hisham
name: Wafaie, Khaled
name: Mumen Rizk
name: Almuzian, Mohammed
name: Sosly, Rami
name: Bearn, David
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: Table S4. Grading of evidence. (PDF 848 kb)