cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Herbicide, fumigant, and fungicide use and breast cancer risk among farmers' wives
Creators: name: Sandler, D.P.
name: Satagopan, J.
name: Beane Freeman, L.E.
name: Lerro, C.C.
name: Werder, E.J.
name: Koutros, S.
name: Alavanja, M.C.
name: Blair, A.
name: Engel, L.S.
Publisher: name: Wolters Kluwer Health
Year: 2020

description: Background: Evidence from epidemiologic and laboratory studies relating pesticides to breast cancer risk is inconsistent. Women engaging in agricultural work or living in agricultural areas may experience appreciable exposures to a wide range of pesticides, including herbicides, fumigants, and fungicides. Methods: We examined exposure to herbicides, fumigants, and fungicides in relation to breast cancer risk among farmers' wives with no prior history of breast cancer in the Agricultural Health Study. Women provided information on pesticide use, demographics, and reproductive history at enrollment (1993-1997) and at a 5-year follow-up interview. We used Cox proportional hazards regression to estimate associations (hazard ratios [HRs] and 95% confidence intervals [CIs]) between the women's and their husbands' self-reported use of individual pesticides and incident breast cancer risk. Results: Out of 30,594 women, 38% reported using herbicides, fumigants, or fungicides and 1,081 were diagnosed with breast cancer during a median 15.3 years of follow-up. We found elevated risk in relation to women's ever use of the fungicide benomyl (HR = 1.6; 95% CI = 0.9, 2.7) and the herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) (HR = 1.6; 95% CI = 0.8, 3.1) and to their husbands' use of the herbicide 2-(2,4,5-trichlorophenoxy) propionic acid (2,4,5-TP) (HR = 1.5; 95% CI = 0.9, 2.7). We observed few other chemical associations and little evidence of differential risk by tumor estrogen receptor status or linear exposure-response relationships. Conclusion: We did not observe clear excesses between use of specific pesticides and breast cancer risk across exposure metrics, although we did observe elevated risk associated with women's use of benomyl and 2,4,5-T and husbands' use of 2,4,5-TP.
Quasi-arithmeticity of lattices in PO(n,1)
Creators: name: Thomson, Scott
Publisher: name: arXiv
Year: 2014
Subjects: subject: Geometric Topology (math.GT)
subject: Group Theory (math.GR)
subject: FOS: Mathematics
subject: 22E40, 20H10, 11F06

description: We show that the non-arithmetic lattices in PO(n,1) of Belolipetsky and Thomson (2011), obtained as fundamental groups of closed hyperbolic manifolds with short systole, are quasi-arithmetic in the sense of Vinberg, and, by contrast, the well-known non-arithmetic lattices of Gromov and Piatetski-Shapiro are not quasi-arithmetic. A corollary of this is that there are, for all $n\geq 2$, non-arithmetic lattices in PO(n,1) that are not commensurable with the Gromov--Piatetski-Shapiro lattices.
description: 10 pages, 2 figures. This version: minor typos corrected and journal reference added. Final published version available at link.springer.com. Geometriae Dedicata (2015)
Supplementary document for Spectral Peak Recovery in Parametrically Amplified THz-Repetition-Rate Bursts - 6475900.pdf
Creators: name: Stummer, Vinzenz
name: Flöry, Tobias
name: Schneller, Matthias
name: Kaksis, Edgar
name: Zeiler, Markus
name: Pugzlys, Audrius
name: Baltuska, Andrius
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: Uncategorized

description: Supplemental Document
Additional file 1 of The role of companion animals in advanced cancer: an interpretative phenomenological analysis
Creators: name: McGhee, William R. G.
name: Dempster, Martin
name: Graham-Wisener, Lisa
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1:
Additional file 2 of Evaluation of a blended learning approach on stratified care for physiotherapy bachelor students
Creators: name: Adje, Mishael
name: Steinhäuser, Jost
name: Laekeman, Marjan
name: Rogan, Slavko
name: Karstens, Sven
Publisher: name: figshare
Year: 2023
Subjects: Neuroscience
Science Policy
Mental Health

description: Supplementary Material 2
Reproducibility of left ventricular mass by echocardiogram in the ELSA-Brasil
Creators: name: Foppa, Murilo
name: Fernandes, Luciana Pereira
name: Tognon, Alexandre Pereira
name: Duncan, Bruce Bartholow
name: Lotufo, Paulo
name: Chambless, Lloyd Ellwood
name: Luft, Vivian Cristine
name: El Aouar, Lilia Maria Mameri
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: BackgroundEchocardiography, though non-invasive and having relatively low-cost, presents issues of variability which can limit its use in epidemiological studies.ObjectiveTo evaluate left ventricular mass reproducibility when assessed at acquisition (online) compared to when assessed at a reading center after electronic transmission (offline) and also when assessed by different readers at the reading center.MethodsEchocardiographers from the 6 ELSA-Brasil study investigation centers measured the left ventricular mass online during the acquisition from 124 studies before transmitting to the reading center, where studies were read according to the study protocol. Half of these studies were blindly read by a second reader in the reading center.ResultsFrom the 124 echocardiograms, 5 (4%) were considered not measurable. Among the remaining 119, 72 (61%) were women, mean age was 50.2 ± 7.0 years and 2 had structural myocardial abnormalities. Images were considered to be optimal/ good by the reading center for 110 (92.4%) cases. No significant difference existed between online and offline measurements (1,29 g, CI 95% −3.60-6.19), and the intraclass correlation coefficient between them was 0.79 (CI 95% 0.71-0.85). For images read by two readers, the intraclass correlation coefficient was 0.86 (CI 95% 0.78-0.91).ConclusionThere were no significant drifts between online and offline left ventricular mass measurements, and reproducibility was similar to that described in previous studies. Central quantitative assessment of echocardiographic studies in reading centers, as performed in the ELSA-Brasil study, is feasible and useful in clinical and epidemiological studies performed in our setting.
Genetic Modifiers of Atherosclerosis in Mice
Creators: name: Maeda, N.
name: Knowles, J. W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: Atherosclerosis is a complex, multifactorial disease with both genetic and environmental determinants. Experimental investigation of the effects of these determinants on the development and progression of atherosclerosis has been greatly facilitated by the use of targeted mouse models of the disease, particularly those resulting from the absence of functional genes for apolipoprotein E or the low density lipoprotein receptor (LDLR). This review focuses on the influence on atherosclerosis of combining apoE or LDLR deficiencies with factors affecting atherogenesis, including (1) inflammatory processes, (2) glucose metabolism, (3) blood pressure, and (4) coagulation and fibrinolysis. We also discuss the general problem of using the mouse to test the effects on atherogenesis of human polymorphic variations and future ways of enhancing the usefulness of these mouse models.
Increased Atherosclerosis and Smooth Muscle Cell Hypertrophy in Natriuretic Peptide Receptor A-/-Apolipoprotein E-/- Mice
Creators: name: Alexander, M. R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Natriuretic peptide signaling is important in the regulation of blood pressure as well as in the growth of multiple cell types. To examine the role of natriuretic peptide signaling in atherosclerosis, we crossbred mice that lack natriuretic peptide receptor A (NPRA; Npr1−/−) with atherosclerosis-prone mice that lack apolipoprotein E (apoE; Apoe−/−).
The association between residential proximity to brownfield sites and high-traffic areas and measures of immunity
Creators: name: Lodge, E.K.
name: Engel, L.S.
name: Galea, S.
name: Aiello, A.E.
name: Ferrando-Martínez, S.
name: Wildman, D.
name: Uddin, M.
Publisher: name: Springer Nature
Year: 2020

description: The mechanisms by which neighborhood environmental exposures influence health are poorly understood, although immune system dysregulation represents a potential biological pathway. While many neighborhood exposures have been investigated, there is little research on residential proximity to brownfield waste. Using biomarker data from 262 participants in the Detroit Neighborhood Health Study, we estimated the association between proximity to brownfields and heavy traffic and signal joint T-cell receptor excision circles (sjTRECs, a measure of naive T-cell production), C-reactive protein (CRP, a measure of systemic inflammation), and interleukin-6 (IL-6, a pro-inflammatory cytokine). We assessed residential proximity ≤200 m from brownfields and highways on all three biomarkers using multivariate regression. We demonstrated that living ≤200 m from a brownfield site was associated with a 0.30 (95% CI = 0.59, 0.02, p = 0.04) loge-unit decrease in sjTRECs per million whole blood cells, as well as non-significantly elevated levels of CRP and IL-6. Heavy traffic was not associated with any biomarker. Persons living in close proximity to brownfield sites had significantly lower naive T-cell production, suggesting accelerated immune aging. Decreased T-cell production associated with brownfield proximity may be caused by toxicant exposure in brownfield sites, or may serve as a marker of other neighborhood stressors.
Low- and high-level information analyses of transcriptome connecting endometrial-decidua-placental origin of preeclampsia subtypes: A preliminary study
Creators: name: Herdiantri Sufriyana
name: Wu, Yu-Wei
name: Su, Emily Chia-Yu
Publisher: name: F1000 Research Limited
Year: 2023

description: Background. Existing proposed pathogenesis for preeclampsia (PE) was only applied for early onset subtype and did not consider pre-pregnancy and competing risks. We aimed to decipher PE subtypes by identifying related transcriptome that represents endometrial maturation and histologic chorioamnionitis. Methods. We utilized eight arrays of mRNA expression for discovery (n=289), and other eight arrays for validation (n=352). Differentially expressed genes (DEGs) were overlapped between those of: (1) healthy samples from endometrium, decidua, and placenta, and placenta samples under histologic chorioamnionitis; and (2) placenta samples for each of the subtypes. They were all possible combinations based on four axes: (1) pregnancy-induced hypertension; (2) placental dysfunction-related diseases (e.g., fetal growth restriction [FGR]); (3) onset; and (4) severity. Results. The DEGs of endometrium at late-secretory phase, but none of decidua, significantly overlapped with those of any subtypes with: (1) early onset (p-values ≤0.008); (2) severe hypertension and proteinuria (p-values ≤0.042); or (3) chronic hypertension and/or severe PE with FGR (p-values ≤0.042). Although sharing the same subtypes whose DEGs with which significantly overlap, the gene regulation was mostly counter-expressed in placenta under chorioamnionitis (n=13/18, 72.22%; odds ratio [OR] upper bounds ≤0.21) but co-expressed in late-secretory endometrium (n=3/9, 66.67%; OR lower bounds ≥1.17). Neither the placental DEGs at first- nor second-trimester under normotensive pregnancy significantly overlapped with those under late-onset, severe PE without FGR. Conclusions. We identified the transcriptome of endometrial maturation in placental dysfunction that distinguished early- and late-onset PE, and indicated chorioamnionitis as a PE competing risk. This study implied a feasibility to develop and validate the pathogenesis models that include pre-pregnancy and competing risks to decide if it is needed to collect prospective data for PE starting from pre-pregnancy including chorioamnionitis information.
Absence of Hyperlipidemia in LDL Receptor-Deficient Mice Having Apolipoprotein B100 Without the Putative Receptor-Binding Sequences
Creators: name: Maeda, N.
name: Johnson, L. A.
name: Altenburg, M. K.
name: Walzem, R. L.
name: Scanga, L. T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: To examine the effects of apoB100 structure, specifically a mutation in the LDLr binding region, on the production of LDL and development of atherosclerosis in vivo.
Additional file 2 of Macrophage Notch1 inhibits TAK1 function and RIPK3-mediated hepatocyte necroptosis through activation of β-catenin signaling in liver ischemia and reperfusion injury
Creators: name: Xu, Dongwei
name: Qu, Xiaoye
name: Tian, Yizhu
name: Jie, Zhao
name: Xi, Zhifeng
name: Xue, Feng
name: Ma, Xueyun
name: Zhu, Jianjun
name: Xia, Qiang
Publisher: name: figshare
Year: 2022
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1. Supplementary Materials.
Additional file 3 of Evaluation of a blended learning approach on stratified care for physiotherapy bachelor students
Creators: name: Adje, Mishael
name: Steinhäuser, Jost
name: Laekeman, Marjan
name: Rogan, Slavko
name: Karstens, Sven
Publisher: name: figshare
Year: 2023
Subjects: Neuroscience
Science Policy
Mental Health

description: Supplementary Material 3
The First Ones Back: Actor Testimony and the ‘Show Must Go On’ Ethos at the Stratford Festival of Canada in 2021
Creators: name: Lane, Cyrus
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2024
Subjects: actor
Pandemic Shakespeare
Shakespeare
Shakespearean Performance pandemic
Covid 19
Stratford Festival

description: This thesis looks at Shakespearean performance at the Stratford Festival of Canada during its 2021 outdoor ‘pandemic’ season. It argues that the dominant pre-pandemic ‘show must go on’ ethos, that puts institutional well-being ahead of actor well-being, persisted during the pandemic season, even as the Festival implemented painstaking anti-racist and anti-oppressive initiatives. Alongside this argument, the thesis interrogates the ethics around the use of actor testimony in scholarship and attempts to ethically expand its focus from pure Shakespearean performance to include actor statements on institutional practices and policy. Extensive interviews with the 2021 casts of A Midsummer Night’s Dream and R+J are, to this end, at the heart of the study. The paper follows Bridget Escolme’s instruction to use actor testimony dialogically and places these interviews in conversation with contemporary Shakespearean performance theory around labour, disability, diversity, pandemic Shakespeare, the nature of the ‘Shakespearean actor’ in Western culture, and, most importantly, with actor testimony from other sources and the auto-ethnography of the author, a Stratford actor himself. Concentrating on testimony around Zoom, masking, and social distancing during the rehearsal process, the thesis reveals the emotional, physical and financial difficulties the actors took on in order for the show to go on at the Stratford Festival during the Covid-19 pandemic.
Additional file 3 of Macrophage Notch1 inhibits TAK1 function and RIPK3-mediated hepatocyte necroptosis through activation of β-catenin signaling in liver ischemia and reperfusion injury
Creators: name: Xu, Dongwei
name: Qu, Xiaoye
name: Tian, Yizhu
name: Jie, Zhao
name: Xi, Zhifeng
name: Xue, Feng
name: Ma, Xueyun
name: Zhu, Jianjun
name: Xia, Qiang
Publisher: name: figshare
Year: 2022
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 2. Supplementary Table 1.
Supplementary files for "Modular, cement-free, customized headpost and connector-chamber implants for macaques."
Creators: name: Eleni, Psarou
name: Julien, Vezoli
name: Schölvinck Marieke, L.
name: Pierre-Antoine, Ferracci
name: Yufeng, Zhang
name: Iris, Grothe
name: Rasmus, Roese
name: Pascal, Fries
Publisher: name: Zenodo
Year: 2022
Subjects: chronic implants, headpost, connector chamber, macaque, refinement, osseointegration

description: This repository contains the models of the implants and tools that are presented in Psarou et al. Modular, cement-free, customized headpost and connector-chamber implants for macaques. For an easy and interactive visualization of the models, open the respective “eDrawings” files (.html format).
Cellular Procoagulant Activity Dictates Clot Structure and Stability as a Function of Distance From the Cell Surface
Creators: name: Bagnell, C. R.
name: Overmyer, K. A.
name: Campbell, R. A.
name: Wolberg, A. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Thrombin concentration modulates fibrin structure and fibrin structure modulates clot stability; however, the impact of localized, cell surface-driven in situ thrombin generation on fibrin structure and stability has not previously been evaluated.
Additional file 4 of Evaluation of a blended learning approach on stratified care for physiotherapy bachelor students
Creators: name: Adje, Mishael
name: Steinhäuser, Jost
name: Laekeman, Marjan
name: Rogan, Slavko
name: Karstens, Sven
Publisher: name: figshare
Year: 2023
Subjects: Neuroscience
Science Policy
Mental Health

description: Supplementary Material 4
Phase transition in ferromagnetic Ising model with a cell-board external field
Creators: name: González-Navarrete, Manuel
name: Pechersky, Eugene
name: Yambartsev, Anatoly
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mathematical Physics (math-ph)
subject: Probability (math.PR)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We show the presence of a first-order phase transition for a ferromagnetic Ising model on $\mathbb{Z}^2$ with a periodical external magnetic field. The external field takes two values $h$ and $-h$, where $h>0$. The sites associated with positive and negative values of external field form a cell-board configuration with rectangular cells of sides $L_1\times L_2$ sites, such that the total value of the external field is zero. The phase transition holds if $h
description: 24 pages, 4 figures
Additional file 1: of Comparison on simultaneous capillary and venous parasite density and genotyping results from children and adults with uncomplicated malaria: a prospective observational study in Uganda
Creators: name: Lehane, Aine
name: Were, Moses
name: Wade, Martina
name: Musleehat Hamadu
name: Cahill, Megan
name: Kiconco, Sylvia
name: Kajubi, Richard
name: Aweeka, Francesca
name: Mwebaza, Norah
name: Fangyong Li
name: Parikh, Sunil
Publisher: name: Figshare
Year: 2019
Subjects: subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Table S1. Mean difference in parasite density (parasites per ÎźL) at different time points over the course of follow-up in all participants. Table S2. Summary of studies comparing capillary and venous measurements for malaria parameters. (DOCX 26 kb)
Comparison of deconvolution algorithms for GeoMx spatial transcriptomics immune cell data
Creators: name: Walter, Carolin
name: Sandmann, Sarah
name: Klotz, Luisa
name: Varghese, Julian
Publisher: name: F1000 Research Limited
Year: 2023

description: Spatial Transcriptomics (ST) is a powerful Next Generation Sequencing-based technique that combines expression information and spatial context for a given sample, and thus allows new insights into the cellular composition and spatial organization of tissues. Several ST techniques with different structures exist, e.g. grid-based spot data, or marker-based regions of interest (ROI), but most current approaches are limited to multi-cell resolution. A precise estimation of the abundance of cell types in a chosen region of interest is therefore essential for accurate ST data interpretation.
 We compared the performance of deconvolution algorithms regarding the inference of immune cell types on original and published NanoString GeoMx ST data from multiple sclerosis (MS) lesions and lung tumor tissue. Both published and single cell-based custom immune cell profiles were used for the cell type deconvolution, and effects of raw data quality and algorithm parameter settings on the estimated immune cell populations were assessed. With preprocessed immune signature matrices as basis for computational deconvolution, SpatialDecon, FARDEEP, and EPIC consistently identified core immune cell populations in a subset of seven CD68-marked MS regions. Detection of other cell types was more variable, and algorithm-dependent. Lower sample quality generally impeded accurate cell type deconvolution.
Additional file 1: of Comparison on simultaneous caillary and venous parasite density and genotyping results from children and adults with uncomplicated malaria: a prospective observational study in Uganda
Creators: name: Lehane, Aine
name: Were, Moses
name: Wade, Martina
name: Musleehat Hamadu
name: Cahill, Megan
name: Kiconco, Sylvia
name: Kajubi, Richard
name: Aweeka, Francesca
name: Mwebaza, Norah
name: Fangyong Li
name: Parikh, Sunil
Publisher: name: Figshare
Year: 2019
Subjects: subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Table S1. Mean difference in parasite density (parasites per ÎźL) at different time points over the course of follow-up in all participants. Table S2. Summary of studies comparing capillary and venous measurements for malaria parameters. (DOCX 26 kb)
Lung function in oil spill responders 4-6 years after the Deepwater Horizon disaster
Creators: name: Stenzel, M.R.
name: Stewart, P.A.
name: Engel, L.S.
name: Sandler, D.P.
name: Keil, A.P.
name: Garantziotis, S.
name: Kwok, R.K.
name: Lawrence, K.G.
name: Curry, M.D.
name: Umbach, D.M.
name: McGrath, J.A.
name: Jackson, W.B.
Publisher: name: Taylor and Francis Inc.
Year: 2020

description: Oil spill response and clean-up (OSRC) workers were exposed to hazardous airborne chemicals following the 2010 Deepwater Horizon disaster. The aim of this study was to evaluate lung function in workers 4–6 years following the disaster using a prospective cohort. Participants who completed two spirometry test sessions 1–3 years, and 4–6 years after the spill (N = 1,838) were included and forced expiratory volume in 1 s (FEV1; ml), forced vital capacity (FVC; ml), and ratio (FEV1/FVC; %) determined. Linear mixed models were utilized to estimate relationships between OSRC exposures and lung function 4–6 years after the spill and changes since the prior measurement. Despite suggestive reduced lung function at 1–3 years, at the 4–6-year exam workers with total hydrocarbon (THC) exposure 1–2.99 ppm and ≥3 ppm compared to those with ≤0.29 ppm exhibited higher FEV1 (β: 108 ml, 95% CI: 17, 198) and (β: 118 ml, 95% CI: 5, 232), respectively. Compared with support workers, those in higher exposed jobs displayed greater improvement in FEV1 between visits: cleanup on water (β: 143 ml, 95% CI: 35, 250), operations (β: 132 ml, 95% CI: 30, 234) and response (β: 149 ml, 95% CI: 43, 256). Greater FEV1 improvement was also associated with higher versus the lowest level THC exposure: 1–2.99 ppm (β: 134 ml, 95% CI: 57, 210) and ≥3 ppm (β: 205 ml, 95% CI: 109, 301). Lung function decrements seen shortly after the spill were no longer apparent 4–6 years later, with the greatest improvement among those with the highest exposures.
Contribution of Host-Derived Tissue Factor to Tumor Neovascularization
Creators: name: Weitz, J. I.
name: Luyendyk, J. P.
name: Milsom, C.
name: Anderson, G. M.
name: May, L.
name: Yu, J.
name: Mackman, N.
name: Rak, J.
name: Broze, G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The role of host-derived tissue factor (TF) in tumor growth, angiogenesis and metastasis has hitherto been unclear, and was investigated in this study.
FRNK Expression Promotes Smooth Muscle Cell Maturation During Vascular Development and After Vascular Injury
Creators: name: Sayers, R. L.
name: Rojas, M.
name: Parsons, J. T.
name: Taylor, J. M.
name: Mack, C. P.
name: Hayasaka, H.
name: Sundberg-Smith, L. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Smooth muscle cell (SMC) differentiation is a dynamic process that must be tightly regulated for proper vascular development and to control the onset of vascular disease. Our lab previously reported that a specific focal adhesion kinase (FAK) inhibitor termed FRNK (FAK Related Non-Kinase) is selectively expressed in large arterioles when SMC are transitioning from a synthetic to contractile phenotype and that FRNK inhibits FAK-dependent SMC proliferation and migration. Herein, we sought to determine whether FRNK expression modulates SMC phenotypes in vivo.
Additional file 5 of Evaluation of a blended learning approach on stratified care for physiotherapy bachelor students
Creators: name: Adje, Mishael
name: Steinhäuser, Jost
name: Laekeman, Marjan
name: Rogan, Slavko
name: Karstens, Sven
Publisher: name: figshare
Year: 2023
Subjects: Neuroscience
Science Policy
Mental Health

description: Supplementary Material 5
Computational investigations of base drag for squareback automotive geometries
Creators: name: Luckhurst, Sophie
Publisher: name: Figshare
Year: 2019
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies

description: Drag reduction continues to be a high priority for automotive manufactures, to reduce CO2 emissions targets and improve the range of electric vehicles. For squareback geometries, a popular vehicle shape, base pressure drag contributes a large proportion of the overall drag and therefore a robust computational method was developed to characterise wake structures, for chosen simplified models, and their influence on base pressure drag. Within the method development both spatial and temporal resolution were considered and the importance of the replication of flow near the floor of the computational domain identified. Further to this the sensitivity of a highly simplified model, with lateral and vertical symmetry, to experimental misalignment was indicated through analysis of the time-dependent wake. Analysis of the flow fields demonstrated a relationship between the main recirculating structures and the near base flow velocities. A method of manipulating this structure was identified, in the form of rectangular cross-section, horizontal base slats. The slats were designed to be geometrically small to ensure minimal aesthetic impact. A statistically significant drag reduction was achieved due to flow impingement on the upper slat surface and a reduction in near base velocity of the lower recirculation, these mechanisms were also observed on a fully detailed geometry. Further configurations considered an asymmetric slat design and a combination of slats, with the optimum configuration producing a drag reduction of 6 counts (ΔCD = 0.006), worth approximately 0.75gCO2/km or a 3km increase in electric vehicle range. This is especially significant given how small the geometry change is, and highlights how many localised flow modifications can produce large cumulative effects; indicating existing vehicle development strategies should be supplemented by localised feature optimisation.
Human LDL Receptor Enhances Sequestration of ApoE4 and VLDL Remnants on the Surface of Hepatocytes but Not Their Internalization in Mice
Creators: name: Altenburg, M.
name: Maeda, N.
name: Wilder, J.
name: Arbones-Mainar, J.
name: Johnson, L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: In humans, apolipoprotein (apo) E4 is associated with elevated plasma cholesterol levels and a high risk of developing atherosclerosis, whereas apoE2 is protective. Here we investigate the mechanism by which mice expressing human apoE isoforms recapitulate this association when they also express high levels of human low-density lipoprotein receptor (LDLR).
Plasma levels of polychlorinated biphenyls (PCBs) and breast cancer mortality: The Carolina Breast Cancer Study
Creators: name: Tse, C.-K.
name: Parada, H., Jr.
name: Engel, L.S.
name: Troester, M.A.
name: Hoh, E.
name: Olshan, A.F.
name: Sun, X.
Publisher: name: Elsevier GmbH
Year: 2020

description: Background: It is unknown whether carcinogenic and endocrine disrupting polychlorinated biphenyls (PCBs) influence mortality following breast cancer. We examined plasma levels of 17 PCB congeners in association with mortality among women with breast cancer. Methods: Participants included 456 white and 292 black women in North Carolina who were diagnosed with primary invasive breast cancer from 1993 to 1996, and who had PCB and lipid measurements from blood samples obtained an average of 4.1 months after diagnosis. Over a median follow-up of 20.6 years, there were 392 deaths (210 from breast cancer). We used Cox regression to estimate covariate-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause and breast cancer-specific 5-year mortality, and 20-year mortality (conditional on 5-year survival) in association with tertiles and continuous ln-transformed lipid-adjusted PCB levels. Results: The highest (vs. lowest) tertiles of PCB74, PCB99, and PCB118 were associated with 5-year breast cancer-specific mortality HRs of 1.46 (95%CI = 0.86–2.47), 1.57 (95%CI = 0.90–2.73), and 1.86 (95%CI = 1.07–3.23), respectively. Additionally, one-ln unit increases in PCB74, PCB99, PCB118, and total PCBs were each associated with 33–40% increases in 5-year breast cancer-specific mortality rates. The PCBs were not, however, associated with longer-term breast cancer-specific mortality. For all-cause mortality, one-ln unit increases in PCB118, PCB146, PCB153, PCB182, PCB187, and total PCBs were associated with 20–37% increases in 20-year all-cause mortality rates among women who survived at least 5 years. Conclusion: PCBs may increase the risk of short-term breast cancer-specific mortality and long-term all-cause mortality among women with breast cancer.
Unbounded violation of quantum steering inequalities
Creators: name: Marciniak, M.
name: Rutkowski, A.
name: Yin, Z.
name: Horodecki, M.
name: Horodecki, R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We construct steering inequalities which exhibit unbounded violation. The concept was to exploit the relationship between steering violation and uncertainty relation. To this end we apply mutually unbiased bases and anti-commuting observables, known to exibit the strongest uncertainty. In both cases, we are able to procure unbounded violations. Our approach is much more constructive and transparent than the operator space theory approach employed to obtain large violation of Bell inequalities. Importantly, using anti-commuting observables we are able to obtain a {\it dichotomic} steering inequality with unbounded violation. So far there is no analogous result for Bell inequalities. Interestingly, both the dichotomic inequality and one of our inequalities can not be directly obtained from existing uncertainty relations, which strongly suggest the existence of an unknown kind of uncertainty relation.
Dagny Schüler, Einander begegnen und begleiten
Creators: name: Rechberger, Walter H.
name: Mette, Norbert
name: Dormeyer, Detlev
Publisher: name: Diakonia
Year: 1970

description: Diakonia, Bd. 21 Nr. 6 (1990): Diakonia, Band 21, Heft 6
Additional file 1 of Individual competence predominates over host nutritional status in Arabidopsis root exudate-mediated bacterial enrichment in a combination of four Burkholderiaceae species
Creators: name: Cillero, Javier Ignacio
name: Henríquez, Pablo Andrés
name: Ledger, Thomas Warwick
name: Ruz, Gonzalo Andrés
name: González, Bernardo
Publisher: name: figshare
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file 1. Viable cell numbers of Burkholderiaceae strains from single cultures and co-culture combinations on Arabidopsis thaliana root exudates.
Additional file 1 of Leukocyte- and platelet-rich fibrin in endoscopic endonasal skull base reconstruction: study protocol for a multicenter prospective, parallel-group, single-blinded randomized controlled non-inferiority trial
Creators: name: Coucke, Birgit
name: Van Hoylandt, Anaïs
name: Jorissen, Mark
name: Meulemans, Jeroen
name: Decramer, Thomas
name: van Loon, Johannes
name: Vander Poorten, Vincent
name: Theys, Tom
name: Van Gerven, Laura
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Computational Biology

description: Additional file 1: Supplementary table S1. World Health Organization Trial Registration Data Set {2b}.
Probabilistic analysis of Wiedemann's algorithm for minimal polynomial computation
Creators: name: Harrison, Gavin
name: Johnson, Jeremy
name: Saunders, B. David
Publisher: name: arXiv
Year: 2014
Subjects: subject: Symbolic Computation (cs.SC)
subject: FOS: Computer and information sciences
subject: F.2.1; I.1.2

description: Blackbox algorithms for linear algebra problems start with projection of the sequence of powers of a matrix to a sequence of vectors (Lanczos), a sequence of scalars (Wiedemann) or a sequence of smaller matrices (block methods). Such algorithms usually depend on the minimal polynomial of the resulting sequence being that of the given matrix. Here exact formulas are given for the probability that this occurs. They are based on the generalized Jordan normal form (direct sum of companion matrices of the elementary divisors) of the matrix. Sharp bounds follow from this for matrices of unknown elementary divisors. The bounds are valid for all finite field sizes and show that a small blocking factor can give high probability of success for all cardinalities and matrix dimensions.
description: 19 pages. To be published in the Journal of Symbolic Computation, please cite as "Harrison, G., et al. Probabilistic analysis of Wiedemann's algorithm for minimal polynomial computation. J. Symb. Comput. (2015), http://dx.doi.org/10.1016/j.jsc.2015.06.005"
Polymorphisms of the IL1-Receptor Antagonist Gene (IL1RN) Are Associated With Multiple Markers of Systemic Inflammation
Creators: name: Walston, J. D.
name: Jarvik, G. P.
name: Carlson, C. S.
name: Wurfel, M. M.
name: Jenny, N. S.
name: Nickerson, D. A.
name: Desmarais, C.
name: Iribarren, C.
name: Reiner, A. P.
name: Nord, A. S.
name: Williams, O. D.
name: Carty, C. L.
name: Lange, L. A.
name: Rieder, M. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Circulating levels of acute phase reactant proteins such as plasma C-reactive protein (CRP) are likely influenced by multiple genes regulating the innate immune response.
Blood BTEXS and heavy metal levels are associated with liver injury and systemic inflammation in Gulf states residents
Creators: name: Falkner, K.C.
name: Werder, E.J.
name: Cave, M.C.
name: Engel, L.S.
name: Sandler, D.P.
name: Beier, J.I.
name: Gripshover, T.
name: Wahlang, B.
Publisher: name: Elsevier Ltd
Year: 2020

description: Introduction: Exposures to volatile organic compounds and metals have previously been associated with liver diseases including steatohepatitis, although more data are needed. Benzene, toluene, ethylbenzene, xylenes, styrene (BTEXS) and metals were measured in blood samples collected between May 2012–July 2013 from volunteers participating in home visits for the Gulf Long-term Follow-up (GuLF) Study. This cross-sectional analysis evaluates associations of exposure biomarkers with serum liver injury and adipocytokine biomarkers in a sample of 214 men. Methods: Adult nonsmoking men without a history of liver disease or heavy alcohol consumption were included. The serologic disease biomarkers evaluated were the hepatocellular injury biomarker, cytokeratin 18 [whole (CK18 M65) and caspase-cleaved fragment (CK18 M30)]; and adipocytokines. Confounder-adjusted beta coefficients were determined using linear regression models for the overall sample (primary endpoints) and for obesity-classified sub-groups (secondary endpoints). A product interaction term between the exposure of interest and a dichotomized indicator of obesity was included to determine the disease modifying effects of obesity on the biomarker associations. Results: The study sample was 57% white and 51% obese. In the overall sample, lead was positively associated with CK18 M30 (β = 21.7 ± 6.0 (SE), p = 0.0004); IL-1β (β = 32.8 ± 5.2, p < 0.0001); IL-6 (β = 72.8 ± 18.3, p = 0.0001); and IL-8 (β = 140.8 ± 42.2, p = 0.001). Cadmium exposures were associated with increased IL-1β (β = 77.8 ± 26.3, p = 0.003) and IL-8 (β = 419.5 ± 201.2, p = 0.04). There were multiple significant interactions between obesity and exposure to lead, cadmium, benzene and toluene in relation to outcome biomarkers. Among obese participants (n = 108), benzene, lead, and cadmium were each positively associated with CK18 M30, IL-1β, IL-6, and IL-8. In obese subjects, lead was also inversely associated with leptin, and toluene was positively associated with IL-1β. Conclusion: For the overall sample, heavy metal exposures were associated with liver injury (lead only) and/or systemic inflammation (lead and cadmium). Obesity modified the associations between BTEXS and heavy metal exposures on several of the outcome variables. In the obesity subgroup, liver injury was positively associated with lead, cadmium and benzene exposures; systemic inflammation was increased with lead, cadmium, benzene, and toluene exposures; and leptin was inversely associated with lead exposures. The cross-sectional design of this study makes it difficult to determine causality, and all results should be interpreted cautiously. Nonetheless, the potential impact of exposures to lead, cadmium, benzene and toluene in steatohepatitis, an obesity-associated inflammatory liver disease, warrants further investigation.
Positivity of linear maps under tensor powers
Creators: name: Müller-Hermes, Alexander
name: Reeb, David
name: Wolf, Michael M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Mathematical Physics (math-ph)
subject: Operator Algebras (math.OA)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We investigate linear maps between matrix algebras that remain positive under tensor powers, i.e., under tensoring with $n$ copies of themselves. Completely positive and completely co-positive maps are trivial examples of this kind. We show that for every $n\in\mathbb{N}$ there exist non-trivial maps with this property and that for two-dimensional Hilbert spaces there is no non-trivial map for which this holds for all $n$. For higher dimensions we reduce the existence question of such non-trivial "tensor-stable positive maps" to a one-parameter family of maps and show that an affirmative answer would imply the existence of NPPT bound entanglement. As an application we show that any tensor-stable positive map that is not completely positive yields an upper bound on the quantum channel capacity, which for the transposition map gives the well-known cb-norm bound. We furthermore show that the latter is an upper bound even for the LOCC-assisted quantum capacity, and that moreover it is a strong converse rate for this task.
description: 25 pages, no figures
The characterisation and simulation of 3D vision sensors for measurement optimisation
Creators: name: Hodgson, John
Publisher: name: Figshare
Year: 2019
Subjects: subject: 91399 Mechanical Engineering not elsewhere classified
subject: FOS: Mechanical engineering

description: The use of 3D Vision is becoming increasingly common in a range of industrial applications including part identification, reverse engineering, quality control and inspection. To facilitate this increased usage, especially in autonomous applications such as free-form assembly and robotic metrology, the capability to deploy a sensor to the optimum pose for a measurement task is essential to reduce cycle times and increase measurement quality. Doing so requires knowledge of the 3D sensor capabilities on a material specific basis, as the optical properties of a surface, object shape, pose and even the measurement itself have severe implications for the data quality. This need is not reflected in the current state of sensor  haracterisation standards which commonly utilise optically compliant artefacts and therefore can not inform the user of a 3D sensor the realistic expected performance on non-ideal objects.
This thesis presents a method of scoring candidate viewpoints for their ability to perform geometric measurements on an object of arbitrary surface finish. This is achieved by first defining a technology independent, empirical sensor characterisation method which implements a novel variant of the commonly used point density point cloud quality metric, which is normalised to isolate the effect of surface finish on sensor performance, as well as the more conventional assessment of point standard deviation. The characterisation method generates a set of performance maps for a sensor per material which are a function of distance and surface orientation. A sensor simulation incorporates these performance maps to estimate the statistical properties of a point cloud on objects with arbitrary shape and surface finish, providing the sensor has been characterised on the material in question.
A framework for scoring measurement specific candidate viewpoints is presented in the context of the geometric inspection of four artefacts with different surface finish but identical geometry. Views are scored on their ability to perform each measurement based on a novel view score metric, which incorporates the expected point density, noise and occlusion of measurement dependent model features. The simulation is able to score the views reliably on all four surface finishes tested, which range from ideal matt white to highly polished aluminium. In 93% of measurements, a set of optimal or nearly optimal views is correctly selected.
Additional file 2 of Individual competence predominates over host nutritional status in Arabidopsis root exudate-mediated bacterial enrichment in a combination of four Burkholderiaceae species
Creators: name: Cillero, Javier Ignacio
name: Henríquez, Pablo Andrés
name: Ledger, Thomas Warwick
name: Ruz, Gonzalo Andrés
name: González, Bernardo
Publisher: name: figshare
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file 2. Selection of replicates of the 4-member combination to set the next generation inocula.
Six-Dimensional Superconformal Theories and their Compactifications from Type IIA Supergravity
Creators: name: Apruzzi, Fabio
name: Fazzi, Marco
name: Passias, Achilleas
name: Rota, Andrea
name: Tomasiello, Alessandro
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We describe three analytic classes of infinitely many AdS_d supersymmetric solutions of massive IIA supergravity, for d = 7, 5, 4. The three classes are related by simple universal maps. For example, the AdS_7 x M_3 solutions (where M_3 is topologically S^3) are mapped to AdS_5 x Sigma_2 x M'_3, where Sigma_2 is a Riemann surface of genus g >= 2 and the metric on M'_3 is obtained by distorting M_3 in a certain way. The solutions can have localized D6 or O6 sources, as well as an arbitrary number of D8-branes. The AdS_7 case (previously known only numerically) is conjecturally dual to an NS5-D6-D8 system. The field theories in three and four dimensions are not known, but their number of degrees of freedom can be computed in the supergravity approximation. The AdS_4 solutions have numerical "attractor" generalizations that might be useful for flux compactification purposes.
description: 5 pages, 2 figures; v2: new title, new introductory and concluding paragraphs, references added; v3: minor corrections
Quantum computation speedup limits from quantum metrological precision bounds
Creators: name: Demkowicz-Dobrzanski, Rafal
name: Markiewicz, Marcin
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We propose a scheme for translating metrological precision bounds into lower bounds on query complexity of quantum search algorithms. Within the scheme the link between quadratic performance enhancement in idealized quantum metrological and quantum computing schemes becomes clear. More importantly, we utilize results from the field of quantum metrology on a generic loss of quadratic quantum precision enhancement in presence of decoherence to infer an analogous generic loss of quadratic speed-up in oracle based quantum computing. While most of our reasoning is rigorous, at one of the final steps, we need to make use of an unproven technical conjecture. We hope that we will be able to amend this deficiency in the near future, but we are convinced that even without the conjecture proven our results provide a novel and deep insight into relationship between quantum algorithms and quantum metrology protocols.
description: 6 pages, 2 figures
Additional file 6 of Evaluation of a blended learning approach on stratified care for physiotherapy bachelor students
Creators: name: Adje, Mishael
name: Steinhäuser, Jost
name: Laekeman, Marjan
name: Rogan, Slavko
name: Karstens, Sven
Publisher: name: figshare
Year: 2023
Subjects: Neuroscience
Science Policy
Mental Health

description: Supplementary Material 6
Additional file 3 of Individual competence predominates over host nutritional status in Arabidopsis root exudate-mediated bacterial enrichment in a combination of four Burkholderiaceae species
Creators: name: Cillero, Javier Ignacio
name: Henríquez, Pablo Andrés
name: Ledger, Thomas Warwick
name: Ruz, Gonzalo Andrés
name: González, Bernardo
Publisher: name: figshare
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file 3 Growth curves for individual and 4-member coculture of Burkholderiaceae strains.