Integrated Molecular Characterization of Uterine Carcinosarcoma
Creators: name: Kim, Jaegil
name: Shen, Hui
name: Hoffmann, Robert
name: Zhang, Wei
name: Tam, Angela
name: Jones, Steven J.M.
name: Zhang, Jiashan
name: Walter, Vonn
name: David, Mutch
name: Wang, Chen
name: Weisenberger, Daniel J.
name: Cherniack, Andrew D.
name: Weinstein, John N.
name: Dowdy, Sean
name: Soloway, Matthew G.
name: Ling, Shiyun
name: Akbani, Rehan
name: Salvesen, Helga B.
name: Gupta, Manaswi
name: Sougnez, Carrie
name: Jones, Corbin D.
name: Bodenheimer, Tom
name: Verhaak, Roel G.W.
name: Robertson, A. Gordon
name: Yang, Liming
name: Dhalla, Noreen
name: Getz, Gad
name: Leshchiner, Ignaty
name: Wong, Tina
name: Roach, Jeffrey
name: Zmuda, Erik
name: Laird, Peter W.
name: Lai, Phillip H.
name: Lawrence, Michael S.
name: Zenklusen, Jean C.
name: Haussler, David
name: Stewart, Chip
name: Tan, Donghui
name: Mungall, Andrew J.
name: Felau, Ina
name: Naresh, Rashi
name: Thiessen, Nina
name: Olvera, Narciso
name: Schein, Jacqueline E.
name: Liu, Jia
name: Brooks, Denise
name: Hoadley, Katherine A.
name: Mieczkowski, Piotr A.
name: Jefferys, Stuart R.
name: Kandoth, Cyriac
name: Wu, Ye
name: Ramirez, Nilsa C.
name: Rathmell, W. Kimryn
name: Winterhoff, Boris
name: Wise, Lisa
name: Ferguson, Martin L.
name: Kanchi, Rupa S.
name: Gastier-Foster, Julie M.
name: Heiman, David I.
name: Lander, Eric
name: Frazer, Scott
name: Marra, Marco A.
name: Holt, Robert A.
name: Hess, Julian
name: Noble, Michael S.
name: Chudamani, Sudha
name: Lin, Pei
name: Carlsen, Rebecca
name: Baylin, Stephen B.
name: Balu, Saianand
name: Broaddus, Russell R.
name: Cibulskis, Kristian
name: Chuah, Eric
name: Shi, Yan
name: Shih, Juliann
name: Bogomolniy, Faina
name: Zhang, Hailei
name: Sofia, Heidi J.
name: Sipahimalani, Payal
name: Zuna, Rosemary E.
name: Hutter, Carolyn M.
name: Levine, Douglas A.
name: Radenbaugh, Amie J.
name: von Bismarck, Amanda
name: Maglinte, Dennis T.
name: Soslow, Robert A.
name: Saksena, Gordon
name: Mayo, Michael
name: Auman, J. Todd
name: Kucherlapati, Raju
name: Huang, Mei
name: Tse, Kane
name: Wang, Zhining
name: Wan, Yunhu
name: Kasaian, Katayoon
name: Ally, Adrian
name: Bowlby, Reanne
name: Gerken, Mark
name: Tseng, Jill
name: Cline, Melissa
name: Veluvolu, Umadevi
name: Perou, Amy H.
name: Mose, Lisle E.
name: Skelly, Tara
name: Meng, Shaowu
name: Leraas, Kristen M.
name: Zhu, Jing-chun
name: Meyerson, Matthew
name: Pihl, Todd
name: Beroukhim, Rameen
name: Demchok, John A.
name: Dao, Fanny
name: Tarnuzzer, Roy
name: Lichtenberg, Tara M.
name: Frick, Jessica
name: Sheth, Margi
name: Bowen, Jay
name: Zhang, Jiashan (Julia)
name: Hoyle, Alan P.
name: Hu, Xin
name: Voet, Doug
name: Mills, Gordon B.
name: Hayes, D. Neil
name: Liu, Yuexin
name: Broaddus, Russell
name: Lee, Darlene
name: Kerr, Sarah
name: Lolla, Laxmi
name: Wilkerson, Matthew D.
name: Moore, Richard A.
name: Lu, Yiling
name: Bootwalla, Moiz S.
name: Cho, Juok
name: Boice, Lori
name: Sun, Charlie
name: Thorne, Leigh B.
name: Ma, Yussanne
name: Schumacher, Steven E.
name: Balasundaram, Miruna
name: Parker, Joel S.
name: Sadeghi, Sara
name: Robertson, Gordon
name: Liu, Wenbin
name: Perou, Charles M.
name: Gehlenborg, Nils
name: Simons, Janae V.
name: Murray, Bradley A.
name: Mungall, Karen
name: Gabriel, Stacey
name: Van Den Berg, David J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: SummaryWe performed genomic, epigenomic, transcriptomic, and proteomic characterizations of uterine carcinosarcomas (UCSs). Cohort samples had extensive copy-number alterations and highly recurrent somatic mutations. Frequent mutations were found in TP53, PTEN, PIK3CA, PPP2R1A, FBXW7, and KRAS, similar to endometrioid and serous uterine carcinomas. Transcriptome sequencing identified a strong epithelial-to-mesenchymal transition (EMT) gene signature in a subset of cases that was attributable to epigenetic alterations at microRNA promoters. The range of EMT scores in UCS was the largest among all tumor types studied via The Cancer Genome Atlas. UCSs shared proteomic features with gynecologic carcinomas and sarcomas with intermediate EMT features. Multiple somatic mutations and copy-number alterations in genes that are therapeutic targets were identified.