cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Cost-effectiveness of a novel urethral catheter safety device in preventing catheterization injuries in the UK
Creators: name: Croghan, Stefanie M.
name: Malcolm, Robert
name: Flood, Hugh D.
name: Mealing, Stuart
name: Avey, Brooke
name: Leonard, Gavin
name: Wright, James
name: Davis, Niall F.
name: Walsh, Michael T.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Intraurethral catheter balloon inflation is a substantial contributor to significant catheter-related urethral injury. A novel safety valve has been designed to prevent these balloon-inflation injuries. The purpose of this evaluation was to assess the cost-effectiveness of urethral catheterisation with the safety valve added to a Foley catheter versus the current standard of care (Foley catheter alone). The analysis was conducted from the UK public payer perspective on a hypothetical cohort of adults requiring transurethral catheterization. A decision tree was used to capture outcomes in the first 30 days following transurethral catheterization, followed by a Markov model to estimate outcomes over a person’s remaining lifetime. Clinical outcomes included catheter balloon injuries [CBIs], associated short-term complications, urethral stricture disease, life years and QALYs. Health-economic outcomes included total costs, incremental cost-effectiveness ratio, net monetary benefit (NMB) and net health benefit. Over a person’s lifetime, the safety valve was predicted to reduce CBIs by 0.04 per person and CBI-related short-term complications by 0.03 per person, and nearly halve total costs. The safety valve was dominant, resulting in 0.02 QALYs gained and relative cost savings of £93.19 per person. Probabilistic sensitivity analysis indicated that the safety valve would be cost-saving in 97% of simulations run versus standard of care. The addition of a novel safety valve aiming to prevent CBIs during transurethral catheterization to current standard of care was estimated to bring both clinical benefits and cost savings.
Classification of secant defective manifolds near the extremal case
Creators: name: Han, Kangjin
Publisher: name: arXiv
Year: 2011
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14MXX, 14NXX, 14M22

description: Let $X\subset ¶^N$ be a nondegenerate irreducible closed subvariety of dimension $n$ over the field of complex numbers and let $SX\subset¶^N$ be its secant variety. $X\subset¶^N$ is called `secant defective' if $\dim(SX)$ is strictly less than the expected dimension $2n+1$. In \cite{Z1}, F.L. Zak showed that for a secant defective manifold necessarily $N\le{n+2 \choose n}-1$ and that the Veronese variety $v_2(¶^n)$ is the only boundary case. Recently R. Mu$\tilde{\textrm{n}}$oz, J. C. Sierra, and L. E. Solá Conde classified secant defective varieties next to this extremal case in \cite{MSS}.
 In this paper, we will consider secant defective manifolds $X\subset¶^N$ of dimension $n$ with $N={n+2 \choose n}-1-ε$ for $ε\ge0$. First, we will prove that $X$ is a $LQEL$-manifold of type $δ=1$ for $ε\le n-2$ (see Theorem \ref{main_thm}) by showing that the tangential behavior of $X$ is good enough to apply Scorza lemma. Then we will completely describe the above manifolds by using the classification of conic-connected manifolds given in \cite{IR1}. Our method generalizes previous results in \cite{Z1,MSS}.
description: 8 pages, corrected typos and simplified the proof of Corollary 2.3, to appear in Proc. of Amer. Math. Soc
Integrated budget impact model to estimate the impact of introducing selpercatinib as a tumor-agnostic treatment option for patients with RET-altered solid tumors in the US
Creators: name: Bhandari, Naleen Raj
name: Gilligan, Adrienne M.
name: Myers, Julie
name: Ale-Ali, Amine
name: Smolen, Lee
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences

description: To estimate the potential budget impact on US third party payers (commercial or Medicare) associated with addition of selpercatinib as a tumor-agnostic treatment for patients with Rearranged during Transfection (RET)-altered solid tumors. An integrated budget impact model (iBIM) with 3-year (Y) time horizon was developed for 19 RET-altered tumors. It is referred to as an integrated model because it is a single model that integrated results across multiple tumor types (as opposed to tumor-specific models developed traditionally). The model estimated eligible patient populations and included tumor-specific comparator treatments for each tumor type. Estimated annual total costs (2022USD, $) included costs of drug, administration, supportive care, and toxicity. For a one-million-member plan, the number of patients with RET-altered tumors eligible for treatment, incremental total costs, and incremental per-member per-month (PMPM) costs associated with introduction of selpercatinib treatment were estimated. Uncertainty associated with model parameters was assessed using various sensitivity analyses. Commercial perspective estimated 11.68 patients/million with RET-altered tumors as treatment-eligible annually, of which 7.59 (Y1), 8.17 (Y2), and 8.76 (Y3) patients would be selpercatinib-treated (based on forecasted market share). The associated incremental total and PMPM costs (commercial) were estimated to be: $873,099 and $0.073 (Y1), $2,160,525 and $0.180 (Y2), and $2,561,281 and $0.213 (Y3), respectively. The Medicare perspective estimated 55.82 patients/million with RET-altered tumors as treatment-eligible annually, of which 36.29 (Y1), 39.08 (Y2), and 41.87 (Y3) patients would be selpercatinib-treated. The associated incremental total and PMPM costs (Medicare) were estimated to be: $4,447,832 and $0.371 (Y1), $11,076,422 and $0.923 (Y2), and $12,637,458 and $1.053 (Y3), respectively. One-way sensitivity analyses across both perspectives identified drug costs, selpercatinib market share, incidence of RET, and treatment duration as significant drivers of incremental costs. Three-year incremental PMPM cost estimates suggest a modest impact on payer-budgets associated with introduction of tumor-agnostic selpercatinib treatment.
Dactylorhiza majalis P. F. Hunt & Summerh.
Creators: name: Konrad Lauber
name: Gerhart Wagner
name: Andreas Gygax
Publisher: name: Haupt Verlag
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Dactylorhiza
Dactylorhiza majalis

description: Dactylorhiza majalis (Rchb.) P. F. Hunt & Summerh.
Artbeschreibung: Bis 45 cm hoch. Stängel hohl, dünnwandig (durch leichtes Zusammendrücken feststellbar), unter dem Blütenstand mehr als 3 mm dick, mit nur 3-6 Blättern, die obersten den Blütenstand erreichend. Blätter oberseits mit oder ohne Flecken, wenigstens die unteren Tragblätter die Blüten weit überragend, grün bis dunkelrot. Blüten 15-30, meist rot, selten rosa, mit variabler dunkler Musterung.
Blütezeit: 5-6
Standort und Verbreitung in der Schweiz: Feuchte Wiesen, Flachmoore / kollin-subalpin / CH
Verbreitung global: Europäisch
Ökologische Zeigerwerte nach Landolt & al. (2010)
BodenfaktorenKlimafaktorenSalztoleranzFeuchtezahl F--Lichtzahl L--Salzzeichen--Reaktionszahl R--Temperaturzahl T--Nährstoffzahl N--Kontinentalitätszahl K--
Volksname Deutscher Name: Breitblättrige Fingerwurz Nom français: Orchis à feuilles larges Nome italiano: Orchide a foglie larghe
description: Published as part of Konrad Lauber, Gerhart Wagner & Andreas Gygax, 2018, Flora Helvetica - Orchidaceae, pp. 1324-1362 in Flora Helvetica, Bern :Haupt Verlag on page 1342
CHERIvoke: Characterising pointer revocation using CHERI capabilities for temporal memory safety
Creators: name: Xia, H
name: Woodruff, J
name: Ainsworth, S
name: Filardo, NW
name: Roe, M
name: Richardson, A
name: Rugg, P
name: Neumann, PG
name: Moore, SW
name: Watson, RNM
name: Jones, TM
Publisher: name: ACM
Year: 2019
Subjects: temporal safety
use-after-free
architecture
security

description: A lack of temporal safety in low-level languages has led to an epidemic of use-after-free exploits. These have surpassed in number and severity even the infamous buffer-overflow exploits violating spatial safety. Capability addressing can directly enforce spatial safety for the C language by enforcing bounds on pointers and by rendering pointers unforgeable. Nevertheless, an efficient solution for strong temporal memory safety remains elusive. CHERI is an architectural extension to provide hardware capability addressing that is seeing significant commercial and open- source interest. We show that CHERI capabilities can be used as a foundation to enable low-cost heap temporal safety by facilitating out-of-date pointer revocation, as capabilities enable precise and efficient identification and invalidation of pointers, even when using unsafe languages such as C. We develop CHERIvoke, a technique for deterministic and fast sweeping revocation to enforce temporal safety on CHERI systems. CHERIvoke quarantines freed data before periodically using a small shadow map to revoke all dangling pointers in a single sweep of memory, and provides a tunable trade-off between performance and heap growth. We evaluate the performance of such a system using high-performance x86 processors, and further analytically examine its primary overheads. When configured with a heap-size overhead of 25%, we find that CHERIvoke achieves an average execution-time overhead of under 5%, far below the overheads associated with traditional garbage collection, revocation, or page-table systems.
Integrated budget impact model to estimate the impact of introducing selpercatinib as a tumor-agnostic treatment option for patients with RET-altered solid tumors in the US
Creators: name: Bhandari, Naleen Raj
name: Gilligan, Adrienne M.
name: Myers, Julie
name: Ale-Ali, Amine
name: Smolen, Lee
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences

description: Objective: To estimate the potential budget impact on US third party payers (commercial or Medicare) associated with addition of selpercatinib as a tumor-agnostic treatment for patients with Rearranged during Transfection (RET)-altered solid tumors. Methods: An integrated budget impact model (iBIM) with three-year (Y) time horizon was developed for 19 RET-altered tumors. It is referred to as an integrated model because it is a single model that integrated results across multiple tumor types (as opposed to tumor-specific models developed traditionally). The model estimated eligible patient populations and included tumor-specific comparator treatments for each tumor type. Estimated annual total costs (2022USD, $) included costs of drug, administration, supportive care, and toxicity. For a one-million-member plan, the number of patients with RET-altered tumors eligible for treatment, incremental total costs, and incremental per-member per-month (PMPM) costs associated with introduction of selpercatinib treatment were estimated. Uncertainty associated with model parameters was assessed using various sensitivity analyses. Results: Commercial perspective estimated 11.68 patients/million with RET-altered tumors as treatment-eligible annually, of which 7.59 (Y1), 8.17 (Y2), and 8.76 (Y3) patients would be selpercatinib-treated (based on forecasted market share). The associated incremental total and PMPM costs (commercial) were estimated to be: $873,099 and $0.073 (Y1), $2,160,525 and $0.180 (Y2), and $2,561,281 and $0.213 (Y3), respectively. The Medicare perspective estimated 55.82 patients/million with RET-altered tumors as treatment-eligible annually, of which 36.29 (Y1), 39.08 (Y2), and 41.87 (Y3) patients would be selpercatinib-treated. The associated incremental total and PMPM costs (Medicare) were estimated to be: $4,447,832 and $0.371 (Y1), $11,076,422 and $0.923 (Y2), and $12,637,458 and $1.053 (Y3), respectively. One-way sensitivity analyses across both perspectives identified drug costs, selpercatinib market share, incidence of RET, and treatment duration as significant drivers of incremental costs. Conclusions: Three-year incremental PMPM cost estimates suggest modest impact on payer-budgets associated with introduction of tumor-agnostic selpercatinib treatment.
Pedro Gabe de Massarelos (1788-1831), Hamburger Kaufmann, Herausgeber  einer  Anthologie  portugiesisch-brasilianischer  Literatur,  einer  portugiesischen Grammatik und Volksliedsammler portugiesischer Musik
Creators: name: Obermeier, Franz
Publisher: name: Zenodo
Year: 2024
Subjects: Pedro Gabe de Massarelos
portuguese literature
brazilian literature
germany
reception history
19 th century
portuguese grammar
Hamburg commerce
cultural exchange
hanseatic cities
portuguese diplomats
José Anselmo Correia Henriques
Anthology

description: Pedro Gabe de Massarelos war, wie wir in unserem Beitrag zeigen konnten, eine der Figuren, die im 19. Jahrhundert aus eigenem persönlichen Interesse und vor der Entstehung einer institutionalisierten  Fachforschung  oder  eines  universitären  Unterrichts  des  Portugiesischen  am Austausch zwischen dem portugiesisch-brasilianischen Kulturraum und Deutschland durchaus erfolgreich mit viel persönlichem Engagement mitgewirkt haben. Die Breite seiner Interessen schloss durch die Herausgabe der Grammatik auch die Schaffung der notwendigen Portugiesischkenntnisse bei seinem Leser mit ein. Er publizierte seine Grammatik und Chrestomathie wohl  auch  mit  eigenen  Mitteln.  Die  Chrestomathie  hatte  eine  didaktische  Funktion,  diente aber  auch  dazu,  ein  breites  Panorama  der  damals  in  Deutschland  unbekannten  moderneren portugiesischen  und  in  Auswahl  auch  brasilianischen  Literatur  zu  liefern.  Auch  wenn  viel heute vergessenes Populäres enthalten ist, wird Gabe diesem Anspruch durchaus gerecht, vor allem im Lyrikteil. Neuere Literatur machte er auch durch die Publikation der Werke seines Freundes Correia Henriques in Hamburg bekannt. Seine breite Konzeption der Kultur schlossauch die Sammlung und Weitergabe von volkstümlichen Melodien von damals kaum beachteten portugiesischen Modinhas mit ein, von denen eine immerhin Beethoven zu einer Komposition inspiriert hat.  Gabe  konnte  vor  allem  mit  seiner  bisher  kaum  beachteten  Anthologie  portugiesischer  und brasilianischer Literatur ein umfassendes Bild des Kulturraums für deutsche und französischsprachige Leser in seinem persönlichen Umfeld in Hamburg und darüber hinaus liefern. Dass dies anerkannt wurde, zeigen Urteile von Zeitgenossen. Die Verdienste der Familie Gabe im für  die  portugiesisch-deutschen  Handelsbeziehungen  wurden  später  übrigens  durch  die Verleihung eines portugiesischen Adelstitels an einen Nachkommen gewürdigt.
Searching for planet-driven dust spirals in ALMA visibilities
Creators: name: Stevenson, Edward T.
name: Ribas, Álvaro
name: Speedie, Jessica
name: Booth, Richard A.
name: Clarke, Cathie J.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: ALMA (Atacama Large Millimetre/submillimetre Array) observations of the thermal emission from protoplanetary disc dust have revealed a wealth of substructures that could evidence embedded planets, but planet-driven spirals, one of the more compelling lines of evidence, remain relatively rare. Existing works have focused on detecting these spirals using methods that operate in image space. Here, we explore the planet detection capabilities of fitting planet-driven spirals to disc observations directly in visibility space. We test our method on synthetic ALMA observations of planet-containing model discs for a range of disc/observational parameters, finding it significantly outperforms image residuals in identifying spirals in these observations and is able to identify spirals in regions of the parameter space in which no gaps are detected. These tests suggest that a visibility-space fitting approach warrants further investigation and may be able to find planet-driven spirals in observations that have not yet been found with existing approaches. We also test our method on six discs in the Taurus molecular cloud observed with ALMA at 1.33 mm, but find no evidence for planet-driven spirals. We find that the minimum planet masses necessary to drive detectable spirals range from $\approx$ 0.03 to 0.5 $M_{\text{Jup}}$ over orbital radii of 10 to 100 au, with planet masses below these thresholds potentially hiding in such disc observations. Conversely, we suggest that planets $\gtrsim$ 0.5 to 1 $M_{\text{Jup}}$ can likely be ruled out over orbital radii of $\approx$ 20 to 60 au on the grounds that we would have detected them if they were present.
description: 16 pages, 14 figures, 3 tables. Accepted 2024 April 18 for publication in MNRAS
Dactylorhiza sambucina Soo
Creators: name: Konrad Lauber
name: Gerhart Wagner
name: Andreas Gygax
Publisher: name: Haupt Verlag
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Dactylorhiza
Dactylorhiza sambucina

description: Dactylorhiza sambucina (L.) Soó
Artbeschreibung: Stängel 10-30 cm hoch, beblättert. Blätter verkehrt-eilanzettlich, grösste Breite über der Mitte. Blütenstand gedrungen. Untere Tragblätter ihre Blüten weit überragend. Blüten gelb oder rot mit gelblichem Lippengrund. 3 Perigonblätter zusammenneigend, die 2 seitlichen äusseren aufwärts abstehend. Lippe 8-12 mm lang, rundlich, undeutlich 3teilig oder nur gezähnt. Sporn kegelförmig, abwärts gebogen, 10-18 mm lang.
Blütezeit: 5-6
Standort und Verbreitung in der Schweiz: Wiesen, lichte Waldstellen / montan-subalpin / A, J (nördlich bis Chasseral)
Verbreitung global: Europäisch
Ökologische Zeigerwerte nach Landolt & al. (2010)
BodenfaktorenKlimafaktorenSalztoleranzFeuchtezahl F--Lichtzahl L--Salzzeichen--Reaktionszahl R--Temperaturzahl T--Nährstoffzahl N--Kontinentalitätszahl K--
Volksname Deutscher Name: Holunder-Fingerwurz Nom français: Orchis à odeur de sureau Nome italiano: Orchide sambucina
description: Published as part of Konrad Lauber, Gerhart Wagner & Andreas Gygax, 2018, Flora Helvetica - Orchidaceae, pp. 1324-1362 in Flora Helvetica, Bern :Haupt Verlag on page 1342
Promoting equality in utilization of basic public health services in China: the role of the family doctor contract service
Creators: name: Lai, Sha
name: Huang, Yawei
name: Zhang, Xiaolong
name: Wang, Zechen
name: Feng, Junfei
name: Zhou, Zhongliang
name: Shen, Chi
name: Lu, Li
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: The Family Doctor Contract Service (FDCS) system is a service model for primary care reform launched in 2016 to offer families and individuals active and continuous health care by a team of family doctors within primary care institutions in China. This study aimed to estimate socioeconomic-related inequalities in the utilization of basic public health services, and to identify the contribution of FDCS to promoting equality. Data for the study were collected from a 2023 cross-sectional household health survey in western China, involving 39,456 participants. The concentration index (C) was employed for analyzing the extent of socioeconomic-related inequalities in the utilization of basic public health services and the coarsened exact matching technique was employed for sensitivity analysis in order to reduce selection bias. Our results indicated pro-poor inequalities in the utilization of health records (C = −0.046), free health check-ups (C = −0.009), and follow-ups for hypertension (C = −0.051). Additionally, a more equitable distribution across the economic spectrum was observed within the FDCS group (people who voluntarily contracted for services) compared to the non-FDCS group. The FDCS demonstrated more favorable positive impacts among individuals with higher (quintiles 60–80%) and the highest (top 20%) socioeconomic status. The FDCS contributed 83.94%, 59.24%, and 36.92% to pro-poor inequalities in the utilization of three basic public health services. These contributions reflected the positive impact of the FDCS on utilization. Government policy and service delivery models require a paradigm shift to promote a stronger primary healthcare approach to practice, as evidenced by the effectiveness of the FDCS in promoting equality.
Asynch-SGBDT: Asynchronous Parallel Stochastic Gradient Boosting Decision Tree based on Parameters Server
Creators: name: Daning, Cheng
name: Fen, Xia
name: Shigang, Li
name: Yunquan, Zhang
Publisher: name: arXiv
Year: 2018
Subjects: subject: Machine Learning (cs.LG)
subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: In AI research and industry, machine learning is the most widely used tool. One of the most important machine learning algorithms is Gradient Boosting Decision Tree, i.e. GBDT whose training process needs considerable computational resources and time. To shorten GBDT training time, many works tried to apply GBDT on Parameter Server. However, those GBDT algorithms are synchronous parallel algorithms which fail to make full use of Parameter Server. In this paper, we examine the possibility of using asynchronous parallel methods to train GBDT model and name this algorithm as asynch-SGBDT (asynchronous parallel stochastic gradient boosting decision tree). Our theoretical and experimental results indicate that the scalability of asynch-SGBDT is influenced by the sample diversity of datasets, sampling rate, step length and the setting of GBDT tree. Experimental results also show asynch-SGBDT training process reaches a linear speedup in asynchronous parallel manner when datasets and GBDT trees meet high scalability requirements.
Tromatobia forsiusi
Creators: name: Varga, Oleksandr
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Ichneumonidae
Tromatobia
Tromatobia forsiusi

description: Tromatobia forsiusi (Hellen, 1915) (Fig. 14)
Records. New record.
Material examined. Cherkasy Reg.: 2 ♀, Zolotonosha Distr., Chekhivka, SN, 22.viii.1984, leg. V. Tolkanitz.
Distribution. Palaearctic; Ukraine: Cherkasy Reg.
Biology. EEFS. August.
description: Published as part of Varga, Oleksandr, 2019, Taxonomy and distribution of pimpline parasitoids (Hymenoptera, Ichneumonidae, Pimplinae) in Ukraine, pp. 1-65 in Zootaxa 4693 (1) on page 42, DOI: 10.11646/zootaxa.4693.1.1, http://zenodo.org/record/3529018
Tricomplex Distance Estimation for Filled-in Julia Sets and Multibrot Sets
Creators: name: Parisé, Pierre-Olivier
name: Brouillette, Guillaume
name: Rochon, Dominic
Publisher: name: arXiv
Year: 2018
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 37F50, 32A30, 30G35, 00A69

description: In this article, we present a distance estimation formula that can be used to ray trace 3D slices of the filled-in Julia sets and the Multibrot sets generated by the tricomplex polynomials of the form $η^p+c$ where $p$ is any integer greater than $1$.
title: Functionality of the Na⁺-translocating NADH:quinone oxidoreductase and quinol:fumarate reductase from Prevotella bryantii inferred from homology modeling
Creators: name: Hau, Jann-Louis
name: Schleicher, Lena
name: Herdan, Sebastian
name: Simon, Jörg
name: Seifert, Jana
name: Fritz, Günter
name: Steuber, Julia
Publisher: name: Springer
Year: 2025

description: Members of the family Prevotellaceae are Gram-negative, obligate anaerobic bacteria found in animal and human microbiota. In Prevotella bryantii, the Na+-translocating NADH:quinone oxidoreductase (NQR) and quinol:fumarate reductase (QFR) interact using menaquinone as electron carrier, catalyzing NADH:fumarate oxidoreduction. P. bryantii NQR establishes a sodium-motive force, whereas P. bryantii QFR does not contribute to membrane energization. To elucidate the possible mode of function, we present 3D structural models of NQR and QFR from P. bryantii to predict cofactor-binding sites, electron transfer routes and interaction with substrates. Molecular docking reveals the proposed mode of menaquinone binding to the quinone site of subunit NqrB of P. bryantii NQR. A comparison of the 3D model of P. bryantii QFR with experimentally determined structures suggests alternative pathways for transmembrane proton transport in this type of QFR. Our findings are relevant for NADH-dependent succinate formation in anaerobic bacteria which operate both NQR and QFR.
Cost-effectiveness of a novel urethral catheter safety device in preventing catheterization injuries in the UK
Creators: name: Croghan, Stefanie
name: Malcolm, Robert
name: Flood, Hugh
name: Mealing, Stuart
name: Avey, Brooke
name: Leonard, Gavin
name: Wright, James
name: Davis, Niall
name: Walsh, Michael
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Intraurethral catheter balloon inflation is a substantial contributor to significant catheter-related urethral injury. A novel safety valve has been designed to prevent these balloon-inflation injuries. The purpose of this evaluation was to assess the cost-effectiveness of urethral catheterisation with the safety valve added to a Foley catheter versus the current standard of care (Foley catheter alone). The analysis was conducted from the UK public payer perspective on a hypothetical cohort of adults requiring transurethral catheterization. A decision tree was used to capture outcomes in the first 30 days following transurethral catheterization, followed by a Markov model to estimate outcomes over a person’s remaining lifetime. Clinical outcomes included catheter balloon injuries [CBIs], associated short-term complications, urethral stricture disease, life years and QALYs. Health-economic outcomes included total costs, incremental cost-effectiveness ratio, net monetary benefit (NMB) and net health benefit. Over a person’s lifetime, the safety valve was predicted to reduce CBIs by 0.04 per person and CBI-related short-term complications by 0.03 per person, and nearly halve total costs. The safety valve was dominant, resulting in 0.02 QALYs gained and relative cost savings of £93.19 per person. Probabilistic sensitivity analysis indicated that the safety valve would be cost-saving in 97% of simulations run versus standard of care. The addition of a novel safety valve aiming to prevent CBIs during transurethral catheterization to current standard of care was estimated to bring both clinical benefits and cost savings.
Additional file 8 of Sampling-based Bayesian approaches reveal the importance of quasi-bistable behavior in cellular decision processes on the example of the MAPK signaling pathway in PC-12 cell lines
Creators: name: Jensch, Antje
name: Thomaseth, Caterina
name: Radde, Nicole
Publisher: name: Figshare
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Sensitivity analysis of the simulation-based classification scheme. (PDF 175 kb)
A simple symmetric exclusion process driven by an asymmetric tracer particle
Creators: name: Ayyer, Arvind
Publisher: name: arXiv
Year: 2020
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Mathematical Physics (math-ph)
subject: Combinatorics (math.CO)
subject: Probability (math.PR)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 82C05, 82C22, 82C23, 60J27, 05A15, 05A18

description: We consider an exclusion process on a periodic one-dimensional lattice where all particles perform simple symmetric exclusion at rate $1$ except for a single tracer particle, which performs partially simple asymmetric exclusion with rate $p$ to the right and rate $q$ to the left. This model was first considered by Ferrari, Goldstein and Lebowitz (Progr. Phys., 1985) as a test for the validity of the Einstein relation in microscopic systems.
 The main thrust of this work is an exact solution for the steady state of this exclusion process. We show that the stationary probabilities factorize and give an exact formula for the nonequilibrium partition function. Perhaps surprisingly, we find that the nonequilibrium free energy in the steady state is not well-defined for this system in the thermodynamic limit for any values of $p$ and $q$ if $p \neq q$. We provide formulas for the current and two-point correlations. When the tracer particle performs asymmetric exclusion ($q=0$), the results are shown to simplify significantly and we find an unexpected connection with the combinatorics of set partitions. Finally, we study the system from the point of view of the tracer particle, the so-called environment process. In the environment process, we show that the density of particles decays exponentially with the scaled position in front of the tracer particle in the thermodynamic limit.
description: 28 pages, 3 figures, minor improvements, final version
Cost‑effectiveness of add‑on dapagliflozin for heart failure with reduced ejection fraction patients without diabetes
Creators: name: Abushanab, Dina
name: Chbib, Salma
name: Kaddoura, Rasha
name: Al Hail, Moza
name: Rouf, Palli Valappila Abdul
name: El-Kassem, Wessam
name: Shah, Jassim
name: Nair, Ramesh
name: Al-Badriyeh, Daoud
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: To evaluate the cost-effectiveness of dapagliflozin added to standard of care (SoC) versus SoC in heart failure with reduced ejection fraction (HFrEF) and without type 2 diabetes mellitus (T2DM) patients from the Qatari healthcare perspective. A lifetime Markov model was developed to evaluate the cost-effectiveness of adding dapagliflozin to SoC based on the findings of Petrie et al., 2020, which were based on the DAPA-HF trial. The model was constructed based on four health states: ‘alive with no event’, ‘urgent visit for heart failure’, ‘hospitalization for heart failure’, and ‘dead’. The model considered 1,000 hypothetical HFrEF and without T2DM patients using 3-month cycles over a lifetime horizon. The outcome of interest was the incremental cost-effectiveness ratio (ICER) per quality-adjusted life-year gained (QALY) and years of life lived (YLL). Utility and cost data were obtained from published sources. A scenario analysis was performed to replace the transition probabilities of events in people without T2DM with the transition probabilities of events irrespective of T2DM status, based on findings of the DAPA-HF trial. Sensitivity analyses were conducted to confirm the robustness of the conclusion. Adding dapagliflozin to SoC was estimated to dominate SoC alone, resulting in 0.6 QALY and 0.8 YLL, at a cost saving of QAR771 (USD211) per person compared with SoC alone, with total healthcare costs of QAR42,413 (USD 11,620) versus 43,184 (USD11,831) per person, respectively. When replacing the transition probabilities of events in people without T2DM with the transition probabilities of events in people irrespective of T2DM status, dapagliflozin was cost-effective at ICER of QAR5,212 (USD1,428) per QALY gained and QAR3,880 (USD1,063) per YLL. In the probabilistic sensitivity analysis, dapagliflozin combined with SoC was cost saving in over 49% of the cases and cost-effective in over 43% of the simulated cases against QALYs gained and YLL. Data from clinical trials were used instead of local data, which may limit the local relevance. However, evidence from the local Qatari population is lacking. Also, indirect costs were not included due to a paucity of available data. Adding dapagliflozin to SoC is likely to be a cost-saving therapy for patients with HFrEF and without T2DM in Qatar.
Dactylorhiza traunsteineri Soo
Creators: name: Konrad Lauber
name: Gerhart Wagner
name: Andreas Gygax
Publisher: name: Haupt Verlag
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Dactylorhiza
Dactylorhiza traunsteineri

description: Dactylorhiza traunsteineri (Rchb.) Soó
Artbeschreibung: Stängel 20-35 cm hoch, kaum hohl, unter dem Blütenstand ca. 2 mm dick, mit höchstens 6 Stängelblättern, die unteren schmal-lanzettlich, höchstens 1,5 cm breit, mit oder ohne Flecken, tragblattähnliche Blätter 0-2, Blüten meist leuchtend purpurrot.
Blütezeit: 5-6
Standort und Verbreitung in der Schweiz: Feuchte Wiesen, Flachmoore / (kollin-)montan-subalpin / CH (selten J, MW und MZ)
Verbreitung global: Alpin
Ökologische Zeigerwerte nach Landolt & al. (2010)
BodenfaktorenKlimafaktorenSalztoleranzFeuchtezahl Fsehr feucht; Feuchtigkeit stark wechselnd (mehr als ± 2 Stufen)Lichtzahl LhellSalzzeichen--Reaktionszahl Rneutral bis basisch (pH 5.5-8.5)Temperaturzahl Tmontan (Wälder mit Buche, Weisstanne, in den Zentralalpen mit Waldföhre)Nährstoffzahl Nmässig nährstoffarm bis mässig nährstoffreichKontinentalitätszahl Ksubozeanisch (hohe Luftfeuchtigkeit, geringe Temperaturschwankungen, eher milde Winter)
Volksname Deutscher Name: Traunsteiners Fingerwurz Nom français: Orchis de Traunsteiner Nome italiano: Orchide di Traunsteiner
description: Published as part of Konrad Lauber, Gerhart Wagner & Andreas Gygax, 2018, Flora Helvetica - Orchidaceae, pp. 1324-1362 in Flora Helvetica, Bern :Haupt Verlag on page 1342
MOESM1 of In vitro activity of anti-malarial ozonides against an artemisinin-resistant isolate
Creators: name: Baumgärtner, Fabian
name: Jourdan, Joëlle
name: Scheurer, Christian
name: Blasco, Benjamin
name: Campo, Brice
name: Mäser, Pascal
name: Wittlin, Sergio
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Table S1. Mean per cent survival (individual values in brackets) of NF54 after 6 h exposure to 500 nM of DHA, OZ439 or OZ277 using the synchronization protocol from Straimer et al. [44]. Table S2. Mean in vitro IC50 values (single values in brackets) for Plasmodium falciparum isolate Cam3.IR539T and NF54 in the 72-h [3H] hypoxanthine assay.
Cost-effectiveness of pembrolizumab as an adjuvant treatment of renal cell carcinoma post-nephrectomy in Switzerland
Creators: name: Schur, Nadine
name: Favre-Bulle, Andrea
name: Flori, Michael
name: Xiao, Ying
name: Lupatsch, Judith E.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Medicine
Cancer
Science Policy
Virology

description: Pembrolizumab has demonstrated significantly prolonged disease-free survival and overall survival (OS) among adult patients post-nephrectomy who have an intermediate-high risk, high-risk, or M1 stage with no evidence of disease (M1 NED) renal cell carcinoma (RCC) with clear cell component. The aim of this study was to evaluate the cost-effectiveness of pembrolizumab for patients with RCC post-nephrectomy versus observation in Switzerland. A previously published Markov model was adapted for the Swiss setting to estimate the cost-effectiveness of adjuvant pembrolizumab versus observation from the Swiss statutory health insurance perspective. Transition probabilities between model states were estimated using survival curves from KEYNOTE-564 (data cut-off: 14 June 2021). Outcomes included costs (2022 Swiss francs [CHF]), quality-adjusted life-years (QALYs), and life-years (LYs), measured over a lifetime horizon. Costs included drug acquisition and administration for adjuvant and subsequent therapy. Both costs and effectiveness were discounted at 3.0% annually. Cost-effectiveness was evaluated at a hypothetical willingness-to-pay (WTP) threshold of CHF 100,000. Sensitivity was assessed through scenario analyses as well as deterministic and probabilistic sensitivity analyses. Over a lifetime horizon, the total incremental cost for pembrolizumab versus observation was CHF 59,089, providing incremental gains of 0.90 QALYs (1.07 LYs); the incremental cost-effectiveness ratio was CHF 65,299/QALY. Pembrolizumab was deemed cost-effective versus observation, with a 69.9% probability of cost-effectiveness. A more recent interim analysis data cut from KEYNOTE-564 with median follow up of 57.2 months has since been published; however, these were not available at the time of analysis. It would likely have minimal impact on transition probabilities from disease-free, and the current approach remains conservative for predicting OS for pembrolizumab. As an adjuvant treatment of RCC post-nephrectomy, pembrolizumab was found to be cost-effective versus observation in Switzerland at a WTP threshold of CHF 100,000/QALY. Policy makers should consider pembrolizumab as an adjuvant treatment for patients with RCC post-nephrectomy when making decisions regarding resource allocation.
Epipactis atrorubens Besser
Creators: name: Konrad Lauber
name: Gerhart Wagner
name: Andreas Gygax
Publisher: name: Haupt Verlag
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Epipactis
Epipactis atrorubens

description: Epipactis atrorubens Besser
Artbeschreibung: Stängel 20-80 cm hoch, oben rötlich. Blätter lanzettlich bis eilanzettlich, 2zeilig angeordnet, länger als die Stängelglieder. Blüten in reichblütiger Traube. Perigonblätter dunkelpurpurn, die äusseren zusammenneigend. Lippe durch eine tiefe Einschnürung quer zweigeteilt (nur bei Epipactis!), etwas kürzer als die Perigonblätter, vorderes Glied mit 2 faltig-krausen Höckern, hinteres schüsselförmig. Kein Sporn. Fruchtknoten dicht und kurz flaumig.
Blütezeit: 6-8
Standort und Verbreitung in der Schweiz: Wälder, trockenwarme Hänge, auf Kalk / kollin-subalpin(-alpin) / CH
Verbreitung global: Eurasiatisch
Ökologische Zeigerwerte nach Landolt & al. (2010)
BodenfaktorenKlimafaktorenSalztoleranzFeuchtezahl Fmässig trocken; Feuchtigkeit stark wechselnd (mehr als ± 2 Stufen)Lichtzahl LhalbschattigSalzzeichen--Reaktionszahl Rneutral bis basisch (pH 5.5-8.5)Temperaturzahl Tmontan (Wälder mit Buche, Weisstanne, in den Zentralalpen mit Waldföhre)Nährstoffzahl Nsehr nährstoffarmKontinentalitätszahl Ksubkontinental (niedrige relative Luftfeuchtigkeit, grosse Temperaturschwankungen, eher kalte Winter)
Volksname Deutscher Name: Braunrote Stendelwurz, Braunrote Sumpfwurz Nom français: Epipactis pourpre noirâtre Nome italiano: Elleborine violacea
description: Published as part of Konrad Lauber, Gerhart Wagner & Andreas Gygax, 2018, Flora Helvetica - Orchidaceae, pp. 1324-1362 in Flora Helvetica, Bern :Haupt Verlag on page 1342
AXBOROTLASHTIRISH JARAYONI.JAMIYAT VA TA'LIMNI AXBOROTLASHTIRISH
Creators: name: Qodirov, Farrux
name: Safarova, Mohinabonu
Publisher: name: Zenodo
Year: 2024

description: Axborotlashgan jamiyat sharoitida axborot va bilimlar boshqaruv, taʼlim va iqtisodiyotni rivojlantirishning muhim omiliga aylanmoqda. Jamiyatni axborotlashtirish – bu zamonaviy axborot-kommunikatsiya texnologiyalari (AKT) yordamida ijtimoiy hayotning barcha sohalariga axborot va raqamli texnologiyalarni joriy etish jarayonidir. Ushbu jarayon taʼlim tizimida ham chuqur o‘zgarishlarni talab qiladi, chunki bilim va malakalarni rivojlantirishda innovatsion texnologiyalar muhim rol o‘ynaydi.
Exploring the Outer Solar System with Solar Sailing Smallsats on Fast-Transit Trajectories and In-Flight Autonomous Assembly of Advanced Science Payloads
Creators: name: Turyshev, Slava G.
name: Helvajian, Henry
name: Friedman, Louis D.
name: Heinsheimer, Tom
name: Garber, Darren
name: Davoyan, Artur
name: Toth, Viktor T.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: We discuss the in-flight autonomous assembly as the means to build advanced planetary science payloads to explore the outer regions of the solar system. These payloads are robotically constructed from modular parts delivered by a group of smallsats (< 20 kg) which are placed on fast solar system transfer trajectories while being accelerated by solar sail propulsion to velocities of ~10 AU/yr. This concept provides the planetary science community with inexpensive, frequent access to distant regions of the solar system with flexible, reconfigurable instruments and systems that are assembled in flight. It permits faster revisit times, rapid replenishment and technology insertions, longer mission capability with lower costs. It also increases the science capabilities of smallsats via the use of modular, redundant architectures and allows for proliferation of sensing instrumentation throughout the solar system.
description: A White Paper to the National Academy of Sciences Planetary Science and Astrobiology Decadal Survey 2023-2032. 7 pages
On the sensitivity of weak gravitational lensing to the cosmic expansion function
Creators: name: Schmidt, Christian F.
name: Bartelmann, Matthias
Publisher: name: arXiv
Year: 2020
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We analyse the functional derivative of the cosmic-shear power spectrum $C_\ell^γ$ with respect to the cosmic expansion function. Our interest in doing so is two-fold: (i) In view of attempts to detect minor changes of the cosmic expansion function which may be due to a possibly time-dependent dark-energy density, we wish to know how sensitive the weak-lensing power spectrum is to changes in the expansion function. (ii) In view of recent empirical determinations of the cosmic expansion function from distance measurements, independent of specific cosmological models, we wish to find out how uncertainties in the expansion function translate to uncertainties in the cosmic-shear power spectrum. We find the following answers: Relative changes of the expansion function are amplified by the cosmic-shear power spectrum by a factor $\approx 2-6$, weakly depending on the scale factor where the change is applied, and the current uncertainty of one example for an empirically determined expansion function translates to a relative uncertainty of the cosmic-shear power spectrum of $\approx10\,\%$.
description: 8 pages, 8 figures, submitted to MNRAS
Promoting equality in utilization of basic public health services in China: The role of the family doctor contract service
Creators: name: Lai, Sha
name: Huang, Yawei
name: Zhang, Xiaolong
name: Wang, Zechen
name: Feng, Junfei
name: Zhou, Zhongliang
name: Shen, Chi
name: Lu, Li
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: The Family Doctor Contract Service (FDCS) system is a service model for primary care reform launched in 2016 to offer families and individuals active and continuous health care by a team of family doctors within primary care institutions in China. This study aimed to estimate socioeconomic-related inequalities in the utilization of basic public health services, and to identify the contribution of FDCS to promoting equality. Data for the study were collected from a 2023 cross-sectional household health survey in western China, involving 39,456 participants. The concentration index (C) was employed for analyzing the extent of socioeconomic-related inequalities in the utilization of basic public health services and the coarsened exact matching technique was employed for sensitivity analysis in order to reduce selection bias. Our results indicated pro-poor inequalities in the utilization of health records (C = -0.046), free health check-ups (C = -0.009), and follow-ups for hypertension (C = -0.051). Additionally, a more equitable distribution across the economic spectrum was observed within the FDCS group (people who voluntarily contracted for services) compared to the non-FDCS group. The FDCS demonstrated more favorable positive impacts among individuals with higher (quintiles 60-80%) and the highest (top 20%) socioeconomic status. The FDCS contributed 83.94%, 59.24%, and 36.92% to pro-poor inequalities in the utilization of three basic public health services. These contributions reflected the positive impact of the FDCS on utilization. Government policy and service delivery models require a paradigm shift to promote a stronger primary healthcare approach to practice, as evidenced by the effectiveness of the FDCS in promoting equality.
MOESM1 of In vitro activity of anti-malarial ozonides against an artemisinin-resistant isolate
Creators: name: Baumgärtner, Fabian
name: Jourdan, Joëlle
name: Scheurer, Christian
name: Blasco, Benjamin
name: Campo, Brice
name: Mäser, Pascal
name: Wittlin, Sergio
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Table S1. Mean per cent survival (individual values in brackets) of NF54 after 6 h exposure to 500 nM of DHA, OZ439 or OZ277 using the synchronization protocol from Straimer et al. [44]. Table S2. Mean in vitro IC50 values (single values in brackets) for Plasmodium falciparum isolate Cam3.IR539T and NF54 in the 72-h [3H] hypoxanthine assay.