cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sonnenfleckenzeichnung Nr. 23458.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 15.09.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Development of Pd-catalyzed functionalization reactions of alkenyl substrates via stabilized Pd alkyl intermediates
Creators: name: Opra, Susanne Maria
Publisher: name: University of Utah
Year: 2012
Subjects: Alkene
Palladium
Alkenyl substrates
Hydroalkoxylation
Styrenes
Hydroarylation

description: The palladium-catalyzed functionalization of sp3-hybridized carbons has been an active area of research in recent years. In order to accomplish such transformations, control of β-hydride elimination is one of the central issues to be addressed. In our group, palladium-catalyzed hydro- and difunctionalization reactions of alkenes have been a long-standing area of interest, and we have developed several catalytic systems that achieve precise control of β-hydride elimination from various Pd complexes. Three of these systems are presented in this thesis. In the first chapter, a hydroalkoxylation of styrenes is discussed. In this method, it is proposed that a Pd hydride is generated via Pd-catalyzed aerobic oxidation of an alcohol solvent. The substrate would then insert into the Pd-H bond to form a Pd alkyl intermediate, which undergoes nucleophilic substitution to yield the overall hydroalkoxylation product. Mechanistic experiments performed in parallel with the development of this transformation highlighted the precise control over relative rates of the different steps that is necessary for the reaction to proceed effectively. Importantly, the stabilization imparted by π-benzyl interactions on the Pd alkyl intermediates was found to be crucial to allow for their functionalization. In the second chapter, an asymmetric hydroarylation of styrenes and dienes is described. This was developed on the basis of several racemic styrene and diene hydroarylation reactions previously reported by our laboratory. Analogously to the hydroalkoxylation, oxidation of the alcohol solvent was proposed to provide the hydrogen incorporated into product; and formation of a Pd π-benzyl or π-allyl intermediate was found to be essential for further functionalization. Toward the development of an asymmetric variant of this reaction, several classes of ligands were explored, with bisoxazolines giving the highest  enantioselectivities. Bisoxazolines were then systematically modified and evaluated. As the effort toward an asymmetric hydroarylation was only moderately successful, we chose to investigate other routes to access hydroarylation-type products, as presented in Chapter 3. Specifically, we decided to access Pd π-allyl complexes from homoallyl electrophiles by "walking" the Pd along the carbon chain of the substrate. This would result in a novel approach to Pd π-allyl complexes and their functionalization, which has the potential to be further developed into an asymmetric reaction. The development of this reaction as well as the preliminary scope and mechanism are presented.
Acidente Vascular Cerebral Isquémico por Infeção por Vírus Varicela Zoster
Creators: name: Jacob, Sylvia Helder
name: Pereira, Sandra
name: Silva, Guilherme
name: Sousa, Raquel
Publisher: name: Portuguese Journal of Pediatrics
Year: 2018

description: Portuguese Journal of Pediatrics, Vol. 49 No. 1 (2018)
Oil reserves in the oil shale and coal deposits of Utah
Creators: name: E. Clarence Schmutz
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Petroleum
subject: Geology
subject: FOS: Earth and related environmental sciences
subject: Economics

description: The great importance of fuels and their utilization to the industrial and domestic progress of cities and nations, has directed the attention of many of our leading scientists, engineers, and forward looking people to newer ways by which our fuel resources can be so utilized to bring many benefits to the general scale and plane of living. Utah is fortunate in having received many years of state and federal cooperative study of her oil shale and coal resources, with respect to their by-products. These studies have proved the reserves of oil in oil shales and coals of Utah to be very extensive, and many times greater than any of the present proved petroleum fields. Recent research and experimental evidences are changing with respect to the order of development of the oil shale and coal reserves. It has been the generally accepted idea that oil shale was a more likely source of oil than coal. Industrial activity, also, has tended more in the development of oil shales than coal for production of oil in the past. But later developments in the manufacture of oil from coal are tending to reverse the situation.
Sonnenfleckenzeichnung Nr. 23370.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 12.06.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
pH and reduction dual-responsive micelles based on novel polyurethanes with detachable poly(2-ethyl-2-oxazoline) shell for controlled release of doxorubicin
Creators: name: Bu, Leran
name: Zhang, Hena
name: Xu, Kang
name: Du, Baixiang
name: Zhu, Caihong
name: Li, Yuling
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: We describe a biodegradable amphiphilic polyurethane (PU) with disulfide bonds in the main chain [PEtOz-b-PU(SS)-b-PEtOz]. This multi-block PU was synthesized using poly (ε-caprolactone) diol (PCL-SS-PCL) and poly (2-ethyl-2-oxazoline) (PEtOz-OH) as soft segments, and bis (2-isocyanatoethyl) disulfide as the hard segment. Acid-sensitive PEtOz-OH was used as a hydrophilic segment for pH sensitivity. And reduction sensitivity was induced via disulfide bonds incorporated into the hydrophobic poly (ε-caprolactone) segment of the amphiphilic PUs. The system can self-assemble to form micelles responsive to pH and reducing conditions. The properties of the micelle were studied with dynamic light scattering and scanning electron microscopy. Doxorubicin (DOX) was chosen as a model drug. The in vitro release studies showed that PEtOz-b-PU(SS)-b-PEtOz micelle could degrade more rapidly and completely in a reductive and acidic environment [10 mM dl-Dithiothreitol, pH 5.0]. The methyl tetrazolium (MTT) assay and fluorescent microscopy confirmed the cytotoxicity of the DOX-loaded micelles. This work provides a promising dual-responsive drug carrier based on amphiphilic PU to achieve efficient drug delivery.
Sonnenfleckenzeichnung Nr. 23389.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 01.07.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung Nr. 23489.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 20.10.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung Nr. 23360.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 02.06.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Da Tumefação Lombar à Espondilodiscite Tuberculosa: Um Caso Clínico de Doença de Pott
Creators: name: Soares, Sara
name: Cardoso, Ana Lúcia
name: Liz, Catarina
name: Pena, Teresa
name: Machado, Leonilde
Publisher: name: Portuguese Journal of Pediatrics
Year: 2018

description: A doença de Pott, também conhecida por espondilodiscite tuberculosa, é uma doença rara. A sintomatologia é insidiosa e inespecífica, sendo os sintomas mais comuns a dor lombar, febre e perda ponderal. Apresenta-se o caso clínico de uma adolescente de 16 anos observada no serviço de urgência por tumefação na zona lombar esquerda com oito dias de evolução, associada a dor lombar e inguinal esquerda em deambulação. Analiticamente apresentava aumento da velocidade de sedimentação. Ecograficamente foi descrita uma lesão nodular volumosa, com áreas de aspeto quisto interno. A ressonância magnética evidenciou lesões sugestivas de espondilodiscite infeciosa em L1-L2, associada a abcesso intra-somático com componente intracanalar epidural anterior, paravertebral anterior lateral direito, e exuberante abcesso paravertebral esquerdo com extensão desde D12-L1 até à região inferior da fossa ilíaca à esquerda, com extensão para os tecidos moles laterias à esquerda, condicionando a tumefação na superfície. O exame anatomopatológico do material drenado da lesão revelou Mycobacterium tuberculosis. A doença de Pott é uma situação potencialmente grave que, tal como outras formas de tuberculose extrapulmonar, constitui um desafio diagnóstico.
description: Portuguese Journal of Pediatrics, Vol. 49 No. 1 (2018)
Hipertensão Renovascular: Casuística de uma Consulta de Nefrologia Pediátrica
Creators: name: Gomes, Clara
name: Cordinhã, Carolina
name: Carmo, Carmen
name: Gomes, Clara
name: Correia, António Jorge
Publisher: name: Portuguese Journal of Pediatrics
Year: 2018

description: Introdução: A hipertensão arterial em idade pediátrica é geralmente secundária e potencialmente tratável, sendo que 3%-10% desta população tem hipertensão renovascular. Este trabalho teve como objetivo avaliar as manifestações clínicas, tratamento e evolução dos doentes com este diagnóstico. Métodos: Estudo retrospetivo descritivo dos casos de hipertensão renovascular admitidos na consulta de nefrologia pediátrica de um hospital de nível III, de janeiro de 2006 a junho de 2016. Resultados: Incluíram-se nove doentes (seis do género masculino, idade média no diagnóstico 6,7 ± 2 anos). O diagnóstico de hipertensão arterial foi feito em contexto de cefaleias num doente, má progressão ponderal noutro, e nos sete restantes que estavam assintomáticos, em avaliação de rotina. Dois tinham patologia sistémica (neurofibromatose tipo I e arterite de Takayasu). A ecografia renal com Doppler identificou estenose da artéria renal em 88,9% dos casos e a angiografia em 100% dos oito casos em que foi realizada (estenose bilateral num doente). Em dois doentes a hipertensão arterial foi controlada farmacologicamente. Nos outros sete, por manutenção da hipertensão arterial (três com hipertensão arterial grave, apesar de quatro fármacos), realizaram-se procedimentos de revascularização (angioplastia em cinco e reimplantação da artéria em dois). Na evolução, três colocaram stent, três complicaram com trombose da artéria renal e nefrectomia. Na última avaliação (média de seguimento de 2,8 anos), três estavam sem terapêutica anti-hipertensora. Discussão: Salienta-se a importância da avaliação sistemática da pressão arterial na criança pois a hipertensão arterial, mesmo grave, pode ser assintomática. A hipertensão renovascular necessita, frequentemente, de vários procedimentos terapêuticos invasivos, não isentos de risco. A investigação etiológica e a intervenção precoces podem retardar a progressão da doença renal e modificar o prognóstico.
description: Portuguese Journal of Pediatrics, Vol. 49 No. 1 (2018)
Ultrafast photophysics of π-conjugated polymers for organic photovoltaic applications
Creators: name: Chhetri, Bill Pandit
Publisher: name: University of Utah
Year: 2012
Subjects: π-conjugated polymers
Ultrafast photophysics
Organic photovoltaic applications

description: In this work, we used the pump-probe photomodulation (PM) spectroscopy technique to measure the transient PM spectrum and decay kinetics in various π - conjugated polymers (PCPs) films and blends with appropriate molecular acceptors. Using two ultrafast laser systems, we covered a broad spectral range from 0.25 - 2.5 eV in the time domain from 100 fs to 1 ns with 150 fs time resolution. We also used continuous wave (CW) photomodulation spectroscopy, photoluminescence, electro-absorption, doping-induced absorption, and x-ray diffraction to study the excitations and other optical properties of PCPs and polymer donor-fullerene acceptor blends. In P3HT/PCBM blend with maximum domain separation we found that although the intrachain excitons in the polymer domains decay within ~ 10 ps, no charge polarons are generated at their expense. Instead, there is a build-up of charge-transfer (CT) excitons at the donor (D) - acceptor (A) interfaces that may dissociate into separated polarons in the D and A domains at a later time. Our results elucidate the charge photogeneration mechanism in polymer/fullerene blends, and unravel the important role of the binding energy in generating free charge polarons. We also studied the photophysics of a low band gap polymer, namely poly-thienophene-benzodithiophene seven (PTB7) film and its blend with acceptor [6,6] phenyl C71 butyric acid methyl ester [PC71BM]. In the CW PM spectrum of PTB7/PC71BM blend, clear signatures of polarons are observed. Whereas PA bands of triplet excitons and trapped polarons are observed in pristine PTB7 film. In the transient ultrafast PA spectrum of PTB7/PC71BM blend, surprisingly, we found singlet exciton, charge transfer exciton and a polaron band that are generated simultaneously; this is different from the transient PM spectrum of P3HT/PCBM blend. We also focused on the photophysics of DOO-PPV with different isotopes and their blends with PCBM. The transient ultrafast PA spectra of all isotope films are dominated by a singlet exciton. Similar results were observed in the isotope/PCBM blends. As in P3HT/PCBM blend, we do not observe the charge transfer exciton and polaron band immediately after photoexcitation, but they show up in the PM spectrum at a later time.
Synthesis and evaluation of polymeric micelle containing piperacillin/tazobactam for enhanced antibacterial activity
Creators: name: Morteza, Milani
name: Roya, Salehi
name: Hamed, Hamishehkar
name: Amir, Zarebkohan
name: Abolfazl, Akbarzadeh
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Infections caused by multidrug-resistant bacteria such as P. aeruginosa are important therapeutic complications. Piperacillin/Tazobactam is considered a safe antimicrobial agent. But we should not ignore the prevalence of resistant strains to this drug. In this work, a new polymeric micelle composed of Piperacillin/Tazobactam-loaded Poly (ethylene glycol) methyl ether-block-poly (lactide-co-glycolide) (PLGA-PEG) was developed to improve the antimicrobial performance of P/T. The SEM and TEM studies of PLGA-PEG micelle showed, semi-spherical morphology with a mean diameter of below 30 nm. Zeta potential results indicated that the surface charge of PLGA-PEG micelle was −2.98 mV, while after encapsulation of P/T, the surface charge decreases to −4.13 mV. Clinical strains of P. aeruginosa were isolated and their resistance pattern against different antibiotics was evaluated. The MIC of free and P/T -Loaded PLGA-PEG micelles was determined. Also, the effect of free or P/T micelle against minimal biofilm eradication concentration and motility inhibition was evaluated. The bacterial isolates were resistant to most common antibiotics. The MIC of the free drug form and micelle form ranged from 4 to 512 µg/ml and 2 to 256 µg/ml, respectively. Generally, micelle showed more effective antibiofilm activities, inhibition of bacterial motility and reducing the MIC than that free drug form.
Hemorragia Feto-Materna Grave Como Causa de Encefalopatia Hipoxico-Isquémica
Creators: name: Ferreira, Lígia M.
name: Coutinho, Inês M.
name: Lima Teixeira, Elsa
name: Lapa, Patrícia
Publisher: name: Portuguese Journal of Pediatrics
Year: 2018

description: A hemorragia feto-materna é a passagem de sangue fetal para a circulação materna e ocorre na maioria das gestações de formainsignificante. Quando a hemorragia é acentuada, pode associar-se a morbimortalidade fetal e neonatal importante. Apresenta-se o caso clínico de um recém-nascido de termo, sexo feminino, de gravidez sem intercorrências até dois dias antes do parto, quando a grávida notou diminuição dos movimentos fetais, tendo sido realizada cesariana emergente no dia da admissão no serviço de urgência, por sofrimento fetal agudo. O recém-nascido apresentou-se pálido, verificando-se posteriormente, anemia acentuada (hemoglobina 2,9 g/dL), choque hipovolémico e encefalopatia hipoxico-isquémica. Perante uma anemia neonatal grave e excluídas as hipóteses de hemólise e descolamento de placenta, evocou-se o diagnóstico de hemorragia feto-materna, confirmado por citometria de fluxo (7,9% de hemoglobina fetal no sangue materno). Os autores pretendem realçar que apesar da hemorragia feto-materna grave ser uma causa rara de anemia neonatal, pode manifestar-se como sofrimento fetal agudo, com morbilidade significativa.
description: Portuguese Journal of Pediatrics, Vol. 49 No. 1 (2018)
Sonnenfleckenzeichnung Nr. 23336.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 05.05.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Attachment security as a mediator of the relationship between marital conflict and youth competence
Creators: name: Traeden, Heather Marcie
Publisher: name: University of Utah
Year: 2013
Subjects: Adolescent
Attachment security
Competence
Marital conflict
Mediator
Youth

description: The marital relationship has been a key element in determining the quality of family life. Child outcomes, both positive and negative, are associated with the quality of the marital relationship, and it has become increasingly evident that children living with marital conflict are at risk for maladjustment. The relationship between interparental conflict and adolescents' competence and behavior has been documented by many studies. Less is known about the influence that mother-child and father-child attachment relationships have in mediating the relationship between children's reactions to marital conflict and youth competence. The study examined whether attachment security mediates the influence of children's reactions to interparental conflict on adolescents' competence over time. Results indicate that attachment security may act as a mediator of the relationship between children's reactions to interparental conflict and youth competence. There was more clear evidence supporting the mediational path for the mother-child attachment relationship than for the father-child attachment relationship. Future research is warranted to better understand the mediational path of father-child attachment security.
Colecistite Aguda Alitiásica por Salmonella enteritidis
Creators: name: De Sousa Damião, Filipe
name: Gouveia, Catarina
name: Visinho, Ana Nunes
Publisher: name: Portuguese Journal of Pediatrics
Year: 2018

description: A colecistite aguda alitiásica define-se como a inflamação aguda da vesícula biliar na ausência de cálculos. Em pediatria representa a principal patologia aguda da vesícula biliar. Anteriormente associada a casos de mau prognóstico e de doença sistémica grave, são cada vez mais os casos de colecistite aguda alitiásica em crianças previamente saudáveis, com patologia infeciosa. A associação com Salmonella enteritidis é pouco frequente. Apresenta-se o caso clínico de um rapaz de 7 anos internado por desidratação no contexto de gastroenterite por Salmonella enteritidis, complicada por colecistite aguda alitiásica. Evoluiu bem após antibioterapia endovenosa, sem necessidade de intervenção cirúrgica. O tropismo da Salmonella pela vesícula biliar é um assunto pouco esclarecido, pelo que é revista resumidamente a literatura mais recente.
description: Portuguese Journal of Pediatrics, Vol. 49 No. 1 (2018)
Sonnenfleckenzeichnung Nr. 23430.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 15.08.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Surface-engineered polyethyleneimine-modified liposomes as novel carrier of siRNA and chemotherapeutics for combination treatment of drug-resistant cancers
Creators: name: Mendes, Livia P.
name: Sarisozen, Can
name: Luther, Ed
name: Pan, Jiayi
name: Torchilin, Vladimir P.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Inorganic Chemistry

description: Modification of nanoparticle surfaces with PEG has been widely considered the gold standard for many years. However, PEGylation presents controversial and serious challenges including lack of functionality, hindered cellular interaction, allergic reactions, and stimulation of IgM production after repetitive dosing that accelerates blood clearance of the nanoparticles. We report the development of novel liposomal formulations surface-modified with a low molecular weight, branched polyethyleneimine (bPEI)–lipid conjugate for use as an alternative to PEG. The formulations had very good stability characteristics in ion- and protein-rich mediums. Protein adsorption onto the liposomal surface did not interfere with the cellular interaction. bPEI-modified liposomes (PEIPOS) showed enhanced association with three different cell lines by up to 75 times compared to plain or PEGylated liposomes and were without carrier toxicity. They also penetrated the deeper layers of 3D spheroids. Encapsulating paclitaxel (PTX) into PEIPOS did not change its main mechanism of action. PEIPOS complexed and intracellularly delivered siRNAs and downregulated resistance-associated proteins. Finally, tumor growth inhibition was observed in a mouse ovarian xenograft tumor model, without signs of toxicity, in animals treated with the siRNA/PTX co-loaded formulation. These complex-in-nature but simple-in-design novel liposomal formulations constitute viable and promising alternatives with added functionality to their PEGylated counterparts.
Capitalism, justice, and human autonomy
Creators: name: Aslantepe, Ilker
Publisher: name: University of Utah
Year: 2012
Subjects: Nozick, Robert - Criticism and interpretation
Cohen, G.A (Gerald Allen), 1941-2009 - Criticism and interpretation
Marx, Karl, 181-1883 - Criticism and interpretation
Autonomy (Philosophy)
Capitalism
Justice

description: This thesis examines the writings of Robert Nozick, G. A. Cohen, and Karl Marx on capitalism, justice, and human autonomy, especially in connection with the  conceptualization of capitalism, exploitation, equality, human autonomy, consciousness, self-realization, self-actualization, and justice. According to Nozick, capitalism is the freest and most just society because he believes it respects the individual rights based on self-ownership, the view that people own themselves and they own whatever they produce. Cohen, on the other hand, believes that Nozick's theory is not compatible with any notion of equality and autonomy, and thus, lacks any commitment to a just society. For him, Nozick tries to justify the inequalities that emerge under a regime based on private property. Also, Cohen thinks that there are close affinities between Marx's critique of capitalism and the libertarian challenge to egalitarianism, in that, both are based on the concept of self-ownership. According to Cohen, because Marx's critique of capitalism is based on moral grounds as an unjust and exploitative social system, his concept of exploitation and the labor theory value are unnecessary or irrelevant for the moral claim that labor is exploited under capitalism. The moral argument has little to do with the extraction of surplus labor as such, but rather with social, distributive injustice. Against this argument advanced by Cohen, this study juxtaposes Marx's notion of exploitation as a characteristic of all class societies, in general, and capitalist exploitation in particular. It shows how the critique of capitalism based on a theory of justice differs from Marx's own critique based on the notion that capitalism undermines human autonomy forming a barrier to real human freedom based on a life of consciousness, selfrealization, and self-actualization.
Diabetes gestacional - Otimização do controlo materno e morbilidade neonatal
Creators: name: Mimoso, Maria Gabriela
Publisher: name: Portuguese Journal of Pediatrics
Year: 2018

description: Introdução - A diabetes gestacional (DG) é uma das complicações médicas mais frequentes na gravidez. O diagnóstico mais precoce e o rigor do controlo metabólico é fundamental para diminuir a morbilidade perinatal. A hiperglicémia materna ao induzir hiperglicémia fetal e consequente hiperinsulinismo, é responsável pela maioria das complicações do feto e no recém-nascido (RN). Objetivo - Avaliar a evolução da morbilidade neonatal de filhos de mães com DG explorando as possíveis correlações entre a morbilidade neonatal e o controlo metabólico materno. População e Métodos - Estudo observacional analítico, retrospetivo descritivo de RN de mães com DG com gravidez unifetal seguida numa Maternidade de nível III (MN3) no período de 1994 e 2013 com o recurso à informação clinica de RN e mães com DG recolhidos de um modo longitudinal sistemático e armazenada em base de dados. Analisou-se a evolução da morbi-mortalidade perinatal em três períodos, agrupados de acordo com o protocolo de diagnóstico e de terapêutica utilizado. Resultados – Analisaram-se 2440 díades mãe-filho. Nestes 20 anos o diagnóstico de DG foi mais precoce, a administração de insulinoterapia mais frequente o que condicionou menor número de RN macrossómicos e melhoria da morbilidade neonatal. Contudo, nos últimos três anos constatámos um aumento do número de RN leves para a idade gestacional e um número superior de RN com hipoglicémia e anomalias congénitas. Conclusão – Ao longo de vinte anos de seguimento foi possível objetivar as grandes etapas no seguimento de mulheres com DG e na morbilidade neonatal a ela associada, evidenciando o interesse da sua monitorização.
description: Portuguese Journal of Pediatrics, Vol. 49 No. 1 (2018)
Revisão dos Casos de MEN2A numa População Pediátrica
Creators: name: Dias, Inês
name: Ferreira, Lígia M.
name: Serra Cetanoa, Joana
name: Piedade, Cláudia
name: Cardoso, Rita
name: Dinis, Isabel
name: Ramos, Manuel
name: Mirante, Alice
Publisher: name: Portuguese Journal of Pediatrics
Year: 2018

description: Introdução: As neoplasias endócrinas múltiplas do tipo 2A consistem na tríade carcinoma medular da tiroide, feocromocitoma e hiperplasia das paratiroides. Os testes genéticos constituem uma ferramenta importante na deteção e seguimento destes doentes. Este estudo tem por objetivo descrever a experiência dos autores no seguimento de crianças diagnosticadas com neoplasias endócrinas múltiplas do tipo 2A. Métodos: Estudo observacional e descritivo de crianças com neoplasias endócrinas múltiplas do tipo 2A, acompanhadas num centro terciário de endocrinologia pediátrica. Foram utilizados os critérios da American Thyroid Association para a definição de risco das mutações encontradas. Resultados: Foram estudadas cinco crianças com neoplasias endócrinas múltiplas do tipo 2A, com idades entre 3-14 anos. Três apresentavam mutações de alto risco e duas de risco moderado. Quatro foram submetidas a tiroidectomia profilática. Uma criança desenvolveu hipoparatiroidismo pós-cirúrgico. Relativamente à análise histológica, uma peça operatória apresentou alterações. Em dois doentes verificou-se ausência de correlação genotípica-fenotípica. Discussão: De acordo com a experiência dos autores, a referenciação tardia para a consulta resultou no atraso da tiroidectomia profilática em dois casos. Após realização de tiroidectomia profilática é mandatório manter a monitorização destes doentes, que vão necessitar de terapêutica de reposição hormonal e de forma a detetar outras potenciais manifestações da doença.
description: Portuguese Journal of Pediatrics, Vol. 49 No. 1 (2018)
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität nach einer Projektion vom 27.12.1970, erstellt von Max Waldmeier am Astrophysikalischen Observatorium Tschuggen in Arosa.
Zusätzlich ist vermerkt: Coelostat
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung am Astrophysikalischen Observatorium Tschuggen in Arosa. Instrumentennachweise: 1950: Visuelles Objektiv an der Coelostatenanlage (15 cm Öffnung und 224 cm Brennweite, projiziertes Sonnenbild D = 25 cm), gemäss Tätigkeitsber. gedr. 1950 für das vorhergehende Jahr, S. 4, sowie Erneuerung, 1967: Instrument: Coudé-Refraktor (15 cm Öffnung und 225 cm Brennweite, projiziertes Sonnenbild D = 25 cm). - Instrumentennachweis gemäss Tätigkeitsber. für das Jahr 1967, S. 1.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt
Morbilidade e Mortalidade em Grandes Prematuros: Leves Versus Adequados para a Idade Gestacional
Creators: name: Neves, Catarina
name: Morais, Sofia
name: Mimoso, Gabriela
Publisher: name: Portuguese Journal of Pediatrics
Year: 2018

description: Introdução: A influência de nascer leve para a idade gestacional sobre a morbilidade e mortalidade permanece controversa. O objetivo deste estudo foi avaliar a morbilidade e mortalidade dos recém-nascidos com idade gestacional inferior a 32 semanas comparando os leves com os de peso adequado à idade gestacional. Métodos: Estudo retrospetivo analítico dos processos clínicos de recém-nascidos com idade gestacional inferior 32 semanas internados, num período de 10 anos, na unidade de cuidados intensivos neonatais duma maternidade de nível III. Foram excluídos gémeos, recém-nascidos com anomalias congénitas graves e recém-nascidos grandes para a idade gestacional. Adotaram-se as curvas de Fenton, considerando-se ser leves para a idade gestacional se percentil do peso de nascimento inferior a 10, adequados para a idade gestacional se percentil entre 10 e 90 e grandes para a idade gestacional se percentil superior a 90. Análise estatística através do SPSS17 com significância para p<0,05. Resultados: Foram incluídos 282 recém-nascidos, tendo sido classificados como leves para a idade gestacional 34 (12,1%). Nestes ocorreram significativamente maior número de nascimentos na nossa maternidade (p = 0,020), partos por cesariana (p < 0,001) e partos induzidos (p < 0,001). Ao primeiro minuto o índice de Apgar foi inferior (p = 0,003), não havendo diferenças ao quinto e 10º minutos. Os adequados à idade gestacional tiveram uma maior incidência de hemorragia peri-intraventricular (p = 0,028). Não houve diferenças estatisticamente significativas nos restantes parâmetros de morbilidade avaliados e na mortalidade. Discussão: Nesta série de recém-nascidos grandes prematuros, ser leve para a idade gestacional não representou maior risco de morbilidade e mortalidade significativa.
description: Portuguese Journal of Pediatrics, Vol. 49 No. 1 (2018)
Biochemically enhanced methane production from coal
Creators: name: Opara, Aleksandra
Publisher: name: University of Utah
Year: 2012
Subjects: Fuel
Methane
Microbial

description: For many years, biogas was connected mostly with the organic matter decomposition in shallow sediments (e.g., wetlands, landfill gas, etc.). Recently, it has been realized that biogenic methane production is ongoing in many hydrocarbon reservoirs. This research examined microbial methane and carbon dioxide generation from coal. As original contributions methane production from various coal materials was examined in classical and electro-biochemical bench-scale reactors using unique, developed facultative microbial consortia that generate methane under anaerobic conditions. Facultative methanogenic populations are important as all known methanogens are strict anaerobes and their application outside laboratory would be problematic. Additional testing examined the influence of environmental conditions, such as pH, salinity, and nutrient amendments on methane and carbon dioxide generation. In 44-day ex-situ bench-scale batch bioreactor tests, up to 300,000 and 250,000 ppm methane was generated from bituminous coal and bituminous coal waste respectively, a significant improvement over 20-40 ppm methane generated from control samples. Chemical degradation of complex hydrocarbons using environmentally benign reagents, prior to microbial biodegradation and methanogenesis, resulted in dissolution of up to 5% bituminous coal and bituminous coal waste and up to 25% lignite in samples tested.
The role of religion in the formation of nationalism, two case studies: Turkish and Armenian nationalisms
Creators: name: Tekkoyun, Ali
Publisher: name: University of Utah
Year: 2012
Subjects: Armenian nationalism
Nationalim
Religion
Turkish nationalism

description: Nationalism provides a rational framework for the formation of a national identity for societies by associating that identity with territory, religion, and/or language. This study takes the association of nationalism with religion into account in the Turkish and Armenian cases with the aim of providing a new perspective to the Armenian question. Instead of ignoring the economic and political reasons, this study seeks the role of religion in the conflict which witnessed violence and resulted in a service of tragedies. Nationalism aiming at building an independence nation-state was a threat for the Ottoman Empire, which consisted of various ethnicities and religions. The Ottoman political and social formation was based on religious identities, which enabled its subjects to keep their ethnic identities, and these gained priority with the influence of nationalism. In order to prevent the dissolution of its millets into essentially national entities, the Ottoman administration tried various policies, namely, Ottomanism, Islamism, and Turkish nationalism, whose common element was to be Islam, which provided the social base and justified the arguments of the ideologies. It was Islam that motivated people to fight against infidels in order to defend the homeland (vatan).  The "self-isolation" process that began with the separation of the Armenian Church from the Greek Church in the fourth century transformed into an Armenian identity characterized by religious and ethnic attachments under the hegemony of foreign powers. In the context; of the Armenian question, the Armenian Gregorian Church contributed to Armenian nationalism by transforming the historical attachments of Armenian identity into nationalist discourses. Religious motivation of people toward nationalistic goals by the religious leaders, such as Mkrdich Khrimian, a member of the Armenian clergy, can easily embrace violence by mobilizing people to sacrifice themselves. Violence has been unavoidable when the politicization of religions, namely Islam and Armenian Gregorian Orthodoxy, toward nationalistic goals takes a place in the same territory. In the context; of the Armenian question, the role of religion needs to be examined within the framework of politicization with nationalist discourses, which will provide an understanding of the origins of the conflict and its tragic results.
Experimental and numerical study on the mechanism of liquefaction flow-slides in gently sloping ground
Creators: name: Amini, Zahra A
Publisher: name: University of Utah
Year: 2012
Subjects: Soil liquefaction
Soil mechanics
Earthquake hazard analysis

description: This study focuses on two major concepts related to the mechanism of liquefaction flow-slides in gently sloping ground, i.e., (a) ultimate steady state strength smaller than static driving shear stress, and (b) void redistribution and water film development in layered sand deposits. The results of a laboratory study based on undrained cyclic and monotonic triaxial tests conducted on a silty-sand characterizing the liquefiable deposit at  the past liquefaction flow-slide sites throughout the Farmington Siding Landslide Complex (FSLC) in Davis County, Utah are used to investigate the minimum slope gradient that would generate flow-sliding in the light of concept (a). An infinite slope analysis using the postliquefaction undrained shear strength from laboratory testing  indicates that a slope gradient much greater than the actual site conditions at the FSLC  (characterized by a mild topography with an average slope gradient not greater than 1%)  would be required to trigger flow failure. This outcome suggests that the flow-slide  concept involving ultimate steady state strength smaller than the static driving shear  stress is inconsistent with the mechanism of large lateral displacements associated with  earthquake-induced ground liquefaction at the FSLC. The geologic setting at the FSLC  strongly favors concept (b), i.e., water film development beneath low permeability  interlayers within a liquefiable deposit, as the potential mechanism characterizing the past  liquefaction flow-slides in the region. In this context, a one-dimensional void  redistribution model for analyzing the generation and dissipation of water films in a  liquefied deposit with a low permeability interlayer has been developed. A parametric  study carried out using the developed numerical model revealed that a decrease in depth  of the silt interlayer would result in thicker water films. The results of the simulation also  indicate that in case of thicker silt interlayers, less water is trapped underneath the silt  interlayer through time and that for lower permeability coefficients of the liquefiable  deposit, larger ground displacements are expected due to larger times required for the  water film to reach its maximum thickness and to dissipate.
Towards optical intensity interferometry for high angular resolution stellar astrophysics
Creators: name: Nunez, Paul D.
Publisher: name: University of Utah
Year: 2012
Subjects: Cherenkov telescopes
Gamma ray astronomy
High angular resolution
Intensity interferometry
Stars

description: Most neighboring stars are still detected as point sources and are beyond the angular resolution reach of current observatories. Methods to improve our understanding of stars at high angular resolution are investigated. Air Cherenkov telescopes (ACTs), primarily used for Gamma-ray astronomy, enable us to increase our understanding of the circumstellar environment of a particular system. When used as optical intensity interferometers, future ACT arrays will allow us to detect stars as extended objects and image their surfaces at high angular resolution. ACTs are used in gamma-ray astronomy to investigate violent phenomena in the universe. However, this technique can also be used for stellar astrophysics on some isolated sources. Such is the case with the X-ray binary LS I +61◦303 which was detected in the TeV range. A gamma-ray attenuation model is developed and applied to this system. This models allows us to place constraints on fundamental properties of the system. However, a much better understanding of this system, and more so of nearby bright stellar systems, could be obtained with high angular resolution techniques. Optical stellar intensity interferometry (SII) with ACT arrays, composed of nearly 100 telescopes, will provide means to measure fundamental stellar parameters and also open the possibility of model-independent imaging. A data analysis algorithm is developed and permits the reconstruction of high angular resolution images from simulated SII data. The capabilities and limitations of future ACT arrays used for high angular resolution imaging are investigated via Monte-Carlo simulations. Simple stellar objects as well as stellar surfaces with localized hot or cool regions can be accurately imaged. Finally, experimental efforts to measure intensity correlations are expounded. The functionality of analog and digital correlators is demonstrated. Intensity correlations have been measured for a simulated star emitting pseudo-thermal light, resulting in angular diameter measurements. The StarBase observatory, consisting of a pair of 3m telescopes separated by 23m, is described.
Effect of immunization on defense mechanisms against infectious disease in irradiated animals
Creators: name: Perkins, Eugene Hafen
Publisher: name: University of Utah
Year: 2012

description: It was observed that a cellular infiltration of phagocytic cells induced in the peritoneum of x-irradiated mice by injection of a 0.1% glycogen saline solution enhanced the resistance of these animals to a later challenge of infection with K. pneumoniae.  A single intraperitoneal injection of heterologous leukocytes (rat or rabbit) administered on any given day in the first postirradiation week failed to significantly reduce mortality of non-challenged irradiated mice.  However animals which received two intraperitoneal injections of homologous phagocytic leukocytes at critical postirradiation periods exhibited reduced mortalities.  Investigation carried on in vitro demonstrated that phagocytic cells of actively immunized animals had a enhanced ability to destroy or inhibit multiplication of viable organisms independent of demonstrable agglutinating antibody.  Similarly in vivo experiments demonstrated that phagocytic cells of actively immunized animals had enhanced phagocytic function in that injections of these cells enhanced the resistance of irradiated mice to subsequent challenge with the homologous organisms whereas cell obtained from norm mice afforded no protection.