cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Properties and applications of rare-earth doped fiber amplifiers and lasers.
Creators: name: Barnard, Chris.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Engineering, Electronics and Electrical.

description: An analytical model for two-, three-, and four-level system rare-earth-doped fiber amplifiers and lasers is presented. Fiber amplifier gain is expressed in terms of easily measured attenuation coefficients, intrinsic saturation powers, and cross saturation powers at the pump and signal wavelengths. System-independent formulas are given for the slopes and thresholds of ring and linear fiber lasers. Good agreement between theory and experiment is shown for erbium-doped fiber amplifiers and lasers and thulium-doped fiber lasers. Approximate system-independent solutions are also given for fiber amplifiers with excited state absorption at either the pump or signal wavelengths. A novel technique, requiring only one tunable light source, is proposed for finding the best pump wavelength when pump ESA is present. Analysis of erbium doped fiber amplifier (EDFA) gain and noise yields a new expression for the amplifier signal-to-noise ratio (SNR) as a function of the fiber length. This leads to a new expression for the fiber length that optimizes the output SNR. Optical gain switching of EDFAs with short pulses at wavelengths within the amplifier bandwidth is modelled to determine how the pump and signal powers, pulse energy, fiber length, and dopant concentration affect the switching time and gain compression. Greater than 20 dB gain compression with nanosecond switching times is demonstrated with good agreement between theory and experiment. Remote EDFA switching from as far as 50 km away is demonstrated. The distance is limited by spontaneous Raman scattering of the switching pulses. These limitations are experimentally and theoretically investigated. Novel configurations are proposed for bidirectional amplification in both single-mode fiber and polarization maintaining fiber. New frequency dependent optical isolators are demonstrated for OTDR testing of amplified fiber links. The new bidirectional amplifier design is much better at attenuating backreflections than a standard EDFA. Polarization separated bidirectional fiber local area networks are proposed. Point-to-point and reflective N-star coupler networks where N = $M\sp2$ or 2$M\sp2$ are considered for an integer M. Reflective star coupler networks use a novel proposed fiber device: an orthogonal polarization variable reflector which can act as an orthogonal polarization full or half reflector. A bidirectional fiber amplifier configuration for polarization separated signals is also proposed.
Engineering curriculum design - Understanding motivational variables and their influence on self-directed learners when using 1:1 mobile devices
Creators: name: Firipis, Arthur
name: Joordens, Matthew
name: Palmer, Stuart
name: Chandraskaren, Siva
Publisher: name: Swinburne
Year: 2024

description: Engineering curriculum design and delivery within the framework of budget restraints, learning outcome policies and industry standards, is a complex task that understandably universities and the engineering industry invest significant resources. It would be expected that what is actually occurring within the engineering learning space is a reflection of the constraints upon the industry, producing graduates, and products and services that provide a return on investment through intellectual capital. Firstly, the literature review will contextualise and explain the engineering student’s motivational variables to actively engage in their learning spaces, and how this may be applied by curriculum designers to improve the quality and delivery of courses. In particular, what are the intrinsic and extrinsic motivational variables and associated values that student’s desire during their engineering learning experience. Secondly, the research study will explore how motivational theory can be applied to the stages of ‘active learning’ when integrating 1:1 mobile devices for engineering learning. 1:1 mobile devices include iPad, mobile phones, Surface Tablets or handheld Wi-Fi or Internet accessible device used for learning purposes. It is not fully understood how to influence ‘active learning using existing teaching and learning strategies. How to influence an engineering undergraduate student to prioritise the use of 1:1 mobile devices as a means to source prescribed and unprescribed curriculum resources to improve learning outcomes. Is it unreasonable to expect engineering students to be constrained to the learning resources supplied by the engineering course facilitated, or should engineering students be encouraged to use their own initiative and find their own supporting information?
InvenioRDM and Devbox
Creators: name: Krägelin, Karl
name: Wiechers, Sarah
Publisher: name: Zenodo
Year: 2024
Subjects: InvenioRDM
Devbox
Developer Experience
NixOS
OR2024

description: This presentation introduces the InvenioRDM development workflow of Uni Münster utilizing devbox for shareable and reproducible development environments.
Dimensional characteristics of FDM 3D printed PEEK implant for craniofacial reconstructions
Creators: name: Sharma, Neha
name: Honigmann, Philipp
name: Cao, Shuaishuai
name: Thieringer, Florian
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2020

description: Additive manufacturing (AM) or three-dimensional (3D) printing is rapidly gaining acceptance in craniomaxillofacial surgeries. Polyetheretherketone (PEEK) patient-specific implants (PSIs) have been used, mainly in reconstructive surgeries, as a reliable alternative to other alloplastic biomaterials. With the use of Fused Deposition Modeling (FDM) 3D printing technology, complex anatomical shaped PEEK PSIs can be fabricated within a clinically acceptable dimensional accuracy range and in a short time-frame. This aspect paves the way for prospective clinical applicability, especially in an in-house 3D printing set-up, where hospitals can utilize this digital AM workflow to provide personalized treatments cost-effectively.
description: Transactions on Additive Manufacturing Meets Medicine, Vol 2 No 1 (2020): Trans. AMMM
Identifying the ligands of the novel [Fe-S] cofactor of the Hepatitis B virus X oncoprotein
Creators: name: Liu, Xingchen
Publisher: name: Brandeis University
Year: 2020
Subjects: Viruses
Hepatitis B
Proteins

description: The Hepatitis B virus (HBV) X protein (HBx) is a regulatory oncoprotein associated with the development of Hepatocellular Carcinoma (HCC) and cirrhosis (Feitelson and Duan 1997, Neuveut et al., 2010). Regardless of the overabundance of reported functions, the structural and functional characteristics of HBx still remain unknown. In this study, we focused on the characterization of the [Fe-S] cluster, recently discovered by us, and the identification of the protein-based coordinating ligands. Soluble HBx fusion proteins were constructed with two different solubility enhancement tag proteins, namely the maltose binding protein (MBP) and the N-utilization substance protein A (NusA). Single-point substitutions of 7 tentative ligand residues (i.e. C7, C61, C69, C137, H139, C143, and C148) to alanine were performed together with larger sequence truncations of 14 (Δ14) or 27 (Δ27) amino acids (aa) at the C-terminus, which are clinically relevant. The extent of [Fe-S] cluster incorporation in the variant proteins was quantified and compared to that in the wild-type HBx. Only some substitutions (C61A, C69A, and C137A, and H139A) resulted in a lesser yield of the [Fe-S] cluster incorporation. However, none of the single-point substitutions was able to abolish completely [Fe-S] cluster formation. We thus adopted two different strategies; a) generation of C-terminal truncated variants, which lack two and three cysteine residues, respectively and b) generation of double- and triple-point substitutions. In addition, apart from monitoring cluster assembly, we also performed kinetic experiments to investigate the O2-sensitivity of the cofactor and its fate upon oxidation. Intriguingly, our results demonstrate that both clinically relevant variants (Δ14, and Δ27) can assemble the same type of [Fe-S] cluster to similar extents, whereas its O2-sensitivity is hardly affected.
Implementation of Design for Additive Manufacturing in rapid product development.
Creators: name: Schutte, Juan
name: Diegel, Olaf
name: Ferreira, Arno
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2020

description: Attempts to contain and prevent the spread of 2020’s CoVID-19 pandemic resulted in major supply-chain limitations. Additive manufacturing provided a potential solution through which the manufacturing of critically needed medical equipment could be facilitated. Whilst this led to innovative initiatives with potentially feasible/beneficial outcomes, some solutions did not account for the limitations of the technology. Here a case study is put forward in which a Design for Additive Manufacturing approach is taken for the feasible development of an automated AMBU-bag based ventilator.
description: Transactions on Additive Manufacturing Meets Medicine, Vol 2 No 1 (2020): Trans. AMMM
British North Americans who fought in the American Civil War, 1861-1865.
Creators: name: Jenkins, Danny R.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1993
Subjects: subject: History, Canadian.

description: Between 33,000 and 55,000 British North Americans (BNAs) fought in the American Civil War. Historians though, have largely overlooked or misinterpreted the BNAs' contribution. Most historical accounts portray BNAs as mercenaries, bounty jumpers, or as the victims of press gangs. Many works imply that most BNAs were kidnapped, or drugged and hauled while unconscious across the border to "volunteer." We are also told that BNAs expended enormous amounts of energy attempting to secure their discharges, and of necessity, had to be placed under guard to prevent their desertion. Nowhere, however, are we informed about average BNAs. Most were neither victims nor abusers of the American recruitment system. Unfortunately, their large and significant contributions to the Union's war effort are all but lost, as historians have tried to capture the more exciting and extraordinary side of BNA recruitment. Such an unbalanced portrayal of BNAs characterizes them as inferior soldiers, and that is a disservice to both BNAs, and to the units in which they served. Much of the misunderstanding surrounding BNAs stems from the lack of a common definition for BNA, and through a failure by researchers to appreciate the significance of the changing nature of the Civil War soldiers' enlistment motivations. My study, on the other hand, concentrates on average BNAs and, in the process, tries to come to grips with their true reasons for enlisting. In the end, the payoff is a more balanced depiction of BNA troops; and the discovery that BNAs were not a homogeneous group of men. There were two basic types: those who resided in the United States before their enlistment, and those who crossed the frontier from the British provinces to volunteer. Both types were willing recruits, but otherwise they showed unique characteristics and enrollment behaviour. American resident BNAs enlisted in patterns much like their American neighbours and friends, while British North American resident BNAs were, in the main, driven by the enlistment bounty. The distinction is important if a better understanding of BNAs is to be achieved.
Digital design and fabrication of controlled porosity, personalized lower limb AFO splints
Creators: name: Mohammed, Mazher
name: Elmo, Frank
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2020

description: We present the preliminary phases of developing a custom lower limb splint concept which considers both design and mechanical elements of the final device. We present an approach to verify the flexural properties of the device through the systematic measurement of flexural stress of 3D printed samples and how this evolves based upon increased porosity. Our initial results demonstrate we can effectively predict the stiffness characteristics of a 3D printed splint concept and apply this to inform the design choices.
description: Transactions on Additive Manufacturing Meets Medicine, Vol 2 No 1 (2020): Trans. AMMM
Studies in pi-facial selectivity.
Creators: name: Dimitroff, Martin.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Chemistry, Organic.

description: A number of dienophiles and ketones have been prepared and the resultant $\pi$-facial selectivity of these substrates in Diels-Alder and nucleophilic additions have been investigated. The ketene equivalent dienophile 46 gave all four possible cycloadducts when reacted with cyclopentadiene under thermal conditions. The resultant $\pi$-facial selectivity was in accord with the calculated electrostatic potential surface of 46. The $\pi$-facial selectivity of the double bond isomer of dienophile 46 was also in accord with the electrostatic potential model. The use of boron trichloride at low temperatures resulted in the isolation of a single endo cycloadduct with complete $\pi$-facial selectivity in the Diels-Alder reaction of 46 with cyclopentadiene. The Cieplak model was not followed in either thermal or Lewis acid-catalyzed conditions employed. The $\pi$-facial selectivity of a number of cyclic ketones containing adjacent heteroatoms using organometallic and reducing agents was examined. The $\pi$-facial selectivity was independent of the size of reducing agent, contrary to results using cyclohexanones. The use of diisobutylaluminum hydride produced a reversal of $\pi$-facial selectivity in cyclopentanones 97, 108, 114, but no reversal was observed with spiro-ketones 129 and 133. The failure of the Cieplak model in many of the reduction reactions indicates that transition state stabilization by hyperconjugation is not an important factor. In many of the cases, electrostatic potential surfaces correctly predicted $\pi$-facial selectivity. Carbon nucleophiles such as methyllithium added to give the major diastereomer predicted by the Cieplak model in all cases examined except tetrahydrofuran 129. The levels of $\pi$-facial selectivity for both carbon nucleophile addition and reduction reactions were at synthetically useful levels for most reagents with the exception of zinc borohydride.* ftn*Please refer to the dissertation for diagrams.
The International Criminal Tribunal for the Former Yugoslavia: An analysis of the legal basis for its operation.
Creators: name: Khan, Ausma Zehanat.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Political Science, International Law and Relations.

description: The premise of this thesis is that the creation of the international Criminal Tribunal for the Former Yugoslavia is a unique initiative aimed at reasserting the perspective of the international community on what type of conduct is considered acceptable and legal in international and internal warfare. The foremost question that must be asked by anyone studying the tribunal is what is it meant to achieve? In my analysis, I focus on three primary issues: (1) what is the legal basis for the operation of the ICTFY? This involves looking both at the law that empowers the tribunal, as well as the laws that the tribunal will rely on in interpreting and prosecuting genocide, war crimes and crimes against humanity. (2) Should the ICTFY be regarded as a mechanism aimed at ending the conflict on the ground, and is this, in fact, a role that tribunals, domestic or international, are supposed to play; and (3) if so, is the ICTFY a successful resolution mechanism? The third question will be answered in the negative. (Abstract shortened by UMI.)
A Mechanism for Phenotypic Tuning of Influenza A Virion Shape During Attenuated Infection
Creators: name: Jaeggi-Wong, Anna
Publisher: name: Brandeis University
Year: 2023
Subjects: Electron Microscopy
Influenza
Viral Infections

description: Filamentous influenza A (IAV) virions can resist inactivation at the level of cell entry. Filaments therefore predominate over spherical particles in clinical infections and may enable viruses to persist and evolve in the face of immune pressure. Despite this, the mechanism of virion shape regulation is not well understood. Shape distribution is currently viewed as a defined feature of a viral genome. However, unpublished data in our lab show that shape can be tuned phenotypically in response to external pressures, without a genetic change. Our goal is to investigate non-genetic determinants of shape in order to begin piecing together the overall mechanism of shape regulation. I performed single-cycle infections with influenza A virus in the presence of inhibitors targeting defined steps in the virus life cycle. I measured the resulting dynamic shape effects using our novel flow virometry approach. Unlike traditional electron microscopy, this technique enables us to measure the shape of many individual fluorescently-labeled virus particles in a high-throughput manner. My results reveal that shape changes actively in response to treatment within a single cycle of infection, in which genetic change is unlikely. Overall, reduced viral yields correlate with increased amounts of filaments. Additionally, I show that inhibiting viral production after endocytosis leads to greater amounts of filaments for greater input particles. This is consistent with host cell membrane surface tension playing a role in phenotypic tuning of shape. I further demonstrate that membrane surface tension can also explain how certain published genetic changes affect shape. Based on our results, we propose shifting the field’s current perspective on virion shape regulation to include both genetics and external environment. Our insight can also be used to inform antiviral strategies, in order to avoid inhibitors which drive formation of filamentous particles.
Conflits profonds et leur résolution.
Creators: name: Palmer, Céline.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Philosophy.

description: Le but de cette these est l'evaluation de differentes tactiques pouvant etre adoptees dans la resolution des conflits profonds. On se demandera jusqu'ou peut aller la raison dans ces entreprises et quelles sont les options qui restent apres l'epuisement des moyens rationnels. La position rationaliste, qui propose des regles pre-etablies a la resolution de differends, sera comparee avec une methode plus souple, qui prefere s'en remettre a l'examen approfondi de chaque cas afin de decouvrir les moyens uniquement appropries a chaque situation particuliere. Une evaluation de differentes techniques d'argumentation logique sera suivie de l'expose de cas de dilemmes. Enfin, une analyse de la facon dont une solution peut etre envisagee dans chaque cas sera presentee.
Determination of the critical closing pressure for a 3D printed collapsible model of an idealized upper airway geometry
Creators: name: Ibbeken, Alina
name: Hagen, Christina
name: Zell, Fenja
name: Steffen, Armin
name: Grzyska, Ulrike
name: Frydrychowicz, Alex
name: Buzug, Thorsten M.
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2020

description: Obstructive sleep apnea is a common sleep disorder caused by a partial or complete collapse of the upper airway due to a shift of soft tissues. A parameter to measure the airway collapsibility is the critical closing pressure, which defines the pharyngeal pressure at which the airway collapses. A 3D printed collapsible model of an idealized upper airway geometry was used to perform deformation and pressure measurements and thus to determine the critical closing pressure. The influence of increasing airway resistance on the deformation behavior was examined by changing the size of the inflow area.
description: Transactions on Additive Manufacturing Meets Medicine, Vol 2 No 1 (2020): Trans. AMMM
Moralesonia D. M. Williams, Ts. Georgiev, T. M. Schust. & C. E. Wetzel 2024, gen. nov.
Creators: name: Williams, David M.
name: Georgiev, Tsvetoslav
name: Schuster, Tanja M.
name: Wetzel, Carlos E.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Sapindales
Rutaceae
Moralesonia

description: Moralesonia D. M. Williams, Ts. Georgiev, T. M. Schust. & C. E. Wetzel gen. nov.
Type species.
Moralesonia frauenfeldii (Grunow) D. M. Williams, Ts. Georgiev, T. M. Schust. & C. E. Wetzel, comb. nov.
Etymology.
Named for the late Eduardo Morales (1968–2023, https://diatoms.org/news/in-memoriam-eduardo-a-morales).
Registration.
http://phycobank.org/104544
Description.
Valves lunate, each with two transapical ribs dividing valve into three ± equal parts. Transapical ribs evident, extending to mantle, internally raised, tapering towards mantle edge. Areolae ± round, radiating from eccentric hyaline centre, sometimes elongated. Rimoportulae absent. Few simple pores on valve surface. Cribra with well-developed, complex volate structure. External surface of valve ornamented. Girdle composed of few bands, all (presumed) copulae. ‘ Central area with radiating areolae’ is the proposed (putative) synapomorphy (diagnostic character) for this genus.
Notes.
We have included all specimens from various parts of the African continent in Moralesonia frauenfeldii and omitted those from other localities for the time being, except from two samples from the Nicobar Islands as they present a similar morphology. These specimens may not be Moralesonia frauenfeldii but, as yet, detailed examination has not been possible (see below). Of these, we have documented them according to the details available to us. The specimens from Australia have been given a specific name, while the others are left without names as relevant characters have yet to be identified. We have SEM details for some specimens from Île Rodriguez, but no LM specimen, so are unable to assign a holotype other than the SEM stub, which we are reluctant to do at this time as their longevity cannot be established with any certainty (Fig. 10 A – F).
description: Published as part of Williams, David M., Georgiev, Tsvetoslav, Schuster, Tanja M. & Wetzel, Carlos E., 2024, The relationships of Eunotogramma frauenfeldii (Bacillariophyta) I. An account of its structure and description of the new genus Moralesonia, pp. 270-290 in Plant Ecology and Evolution 157 (3) on pages 270-290, DOI: 10.5091/plecevo.121829
Using 3D printing to implement a hyperthermia insert for a preclinical MPI scanner
Creators: name: Wei, Huimin
name: Behrends, Andre
name: Friedrich, Thomas
name: Buzug, Thorsten
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2020

description: Magnetic particle imaging (MPI) is a rapidly developing imaging modality, which determines the spatial distribution of magnetic nanoparticles. Magnetic fluid hyperthermia (MFH) is a promising therapeutic approach where magnetic nanoparticles are used to transform electromagnetic energy into heat. The similarities of MPI and MFH give rise to the potential of integration of MFH and MPI. 3D printing is used for the manufacture of an oil-cooled MFH insert. The design and the implementation of a MFH insert for a preclinical MPI scanner is presented in this paper.
description: Transactions on Additive Manufacturing Meets Medicine, Vol 2 No 1 (2020): Trans. AMMM
Differences in experiences of care between patients diagnosed with metastatic cancer of known and unknown primaries: Mixed-method findings from the 2013 cancer patient experience survey in England
Creators: name: Wagland, Richard
name: Bracher, Mike
name: Drosdowsky, Allison
name: Richardson, Alison
name: Symons, John
name: Mileshkin, Linda
name: Schofield, Penelope
Publisher: name: Swinburne
Year: 2024

description: Objectives: To explore differences in experiences of care reported in the Cancer Patient Experience Survey (CPES) between patients with cancer of unknown primary (CUP) and those with metastatic disease of known primary (non-CUP); to determine insights pertaining to the experiences of care for CUP respondents from free-text comments. Design: Two separate, but related, studies, involving secondary analysis of existing data. Using frequency matching of CUP and non-CUP patients, statistical comparisons of responses to CPES questions were conducted. Free-text comments from CUP respondents were analysed thematically. Setting and participants: The CPES questionnaire comprises 63 closed questions measuring 8 areas that relate to experience of care and 3 free-text questions. Questionnaires were mailed to all adult patients (aged ≥16 years) in England with cancer admitted to hospital between 1 September 2013 and 30 November 2013. Results: Matched analysis of closed response items from 2992 patients found significant differences between CUP (n=1496) and non-CUP patients (n=1496): CUP patients were more likely to want more written information about their type of cancer and tests received, to receive their diagnosis from a general practitioner (GP) and have seen allied health professionals, but less likely to have understood explanations of their condition or had surgery. Freetext responses (n=3055) were coded into 17 categories and provided deeper insight regarding patient information and interactions with GPS. CPES data may include a preponderance of patients with favourable CUP subtypes and patients initially identified as CUP but whose primary was subsequently identified. Conclusions: These are the first large-scale studies to explore the experiences of care of CUP patients. The significant differences identified between the experiences of CUP and non-CUP patients suggest CUP patients require more psychosocial support and specific interventions to manage diagnostic uncertainty and the multiple investigations many CUP patients face. Substantial limitations were identified with the CPES data, emphasising the need for prospective studies.
Mechanical performance of electronically functional smart textiles
Creators: name: Merhi, Youssif
name: Mikkelsen, Peter H.
name: Suetta, Charlotte
name: Nygaard, Jens V.
name: Agarwala, Shweta
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2020

description: With advancements in electronics technology, the new-era of devices are flexible and bendable. This has given rise to new smart textiles as wearables. Printed electronics enables to put down electronics on textiles without affecting the flexibility of the fabric. We have developed dry electrodes on healthcare stockings to stimulate muscles to preserve muscle mass in COVID-19 patients. The fabric does not allow direct printing of electronics. Thus, various layers are used. This paper investigates the mechanical strength of these layers on the stocking to remain functional for daily usage. We also discuss washing results on the layers.
description: Transactions on Additive Manufacturing Meets Medicine, Vol 2 No 1 (2020): Trans. AMMM
Sensors integration in additive DMLS metal parts
Creators: name: De Pasquale, Giorgio
name: Buffon, Alberto
name: Bongiorni, Lorenzo
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2020

description: The fabrication of metal parts by laser-based additive manufacturing (AM) processes is providing many applications in the medical field. The layer-by-layer growth of the component provided by powder micromelting allows, at least in theory, the incorporation of discrete sensors and wires inside the metal material. However, several process-related issues make this operation very challenging. This paper introduces the incorporation of thermal and inertial sensors inside 17-4PH steel specimens fabricated by DMLS (direct metal laser sintering) process (PCT/IB2019/053581, 02/05/2018). In the final configuration, the sensors are totally encased into the continuous metal parts with complete protection against contamination and tampering.
description: Transactions on Additive Manufacturing Meets Medicine, Vol 2 No 1 (2020): Trans. AMMM
Selection and characterization of adenylate kinase as a means of assessing ancestral enzyme evolvability
Creators: name: Irvin, Joseph
Publisher: name: Brandeis University
Year: 2023
Subjects: Adenylate kinase
Directed evolution
sacB
Selection
Turbidostat

description: In the directed evolution of enzymes, the starting protein template used is a critical factor in determining the rate at which desirable mutations accumulate. Therefore, a more “evolvable” template capable of supporting a wider range of positive and neutral mutations will lead to faster and more efficient evolution. Ancestral proteins resurrected through ancestral sequence reconstruction (ASR) have been observed to act as highly stable generalists with broader functionalities than modern proteins, and as a result, they are believed to harbor more evolutionary potential than their modern homologs. Using ancestral and modern mutant libraries of the essential enzyme adenylate kinase (ADK) in E. coli with genomic ADK knocked out, evolvability can be assessed and compared through selection experiments performed under the selective pressure of low temperature. Establishment of these cell lines has proven challenging, particularly with regards to persistence of the plasmid pKoComp, which keeps cells alive between knockout of genomic ADK and transformation of library ADK but must later be removed for selection to take place. Additional challenges have arisen regarding the performance and reliability of our custom turbidostat bioreactor, which automates the process of diluting cell cultures to a desirable cell density during selection. In order to streamline and improve the selection process, modifications to the turbidostat bioreactor have improved the instrument’s performance and reliability, and the design and implementation of a conditional toxin counterselection system has shown promise as an additional means of ensuring pKoComp removal.
Direct-seeding Legumes into Orchard Alleys for Nitrogen Production Acknowledgements
Creators: name: Granatstein, David
name: Kirby, Elizabeth
name: Davenport, Joan R
name: Morgan, Warren
name: Kukes, Amos
Publisher: name: Washington State University
Year: 2008
Subjects: legume
cover crop
orchard floor management
Nitrogen Fixation

description: Poster on a legume cover crop research trial in a commerical orchard in Quincy, WA.
Structure Function Analysis of Drosophila OCRL
Creators: name: Ali, Abdulmuhsen
Publisher: name: Brandeis University
Year: 2013
Subjects: OCRL Function Structure

description: Lowe syndrome is an X-linked disorder that is caused by defects in the protein OCRL (Oculocerebrorenal Syndrome of Lowe), a phosphoinositide-5-phosphatase implicated in membrane trafficking, phosphoinositide metabolism, actin dynamics and endocytosis. Despite the fact that OCRL's crystal structure has been solved, the molecular mechanism by which defects in OCRL give rise to Lowe syndrome is not fully understood. Since OCRL is well conserved from mammals to insects, we have used D. melanogaster to recreate a model for Lowe syndrome. We create several site directed-mutations in the single Drosophila homologue of OCRL that disturb important interactions and mimic mutations found in Lowe syndrome patients. We aim to study OCRL's function and subcellular localization by utilizing this insect model for the disease. We found several key amino acids that regulate dOCRL’s capability to bind its partners and control its localization. We hope that in characterizing these conserved residues we are able to shed light on the activity of OCRL to gain a better understanding of Lowe syndrome.
Characterization of YoaA as it Relates to DNA Replication and Repair
Creators: name: Giordano, Gabriela Grace
Publisher: name: Brandeis University
Year: 2021
Subjects: E Coli

description: Effective DNA replication and repair is crucial to the survival of all organisms and necessitates the cooperation of a variety of macromolecules. In Escherichia coli, the DNA Polymerase III holoenzyme is one of these macromolecules which, along with being the main contributor to DNA replication, is known to participate in other interactions which aid in the repair of damaged DNA. One such interaction is with YoaA, a putative helicase found to promote tolerance to replication inhibiting factors. The interaction between YoaA and the DNA Polymerase III holoenzyme takes place at HolC, one of the holoenzyme’s protein subunits. This project seeks to further characterize the interaction between YoaA and HolC while also attempting to identify the types of DNA damage and repair to which YoaA responds. Through Yeast Two-Hybrid, I have shown that the C-terminus of YoaA is the region responsible for HolC binding. Additionally, E. coli growth assays show that mutations in the C-terminus of YoaA may alter the protein’s function in vivo. A variety of phenotypic assays have suggested that YoaA does not exhibit a significant response to recombination events or point mutations.
3D-printing of elastic stenosis phantoms
Creators: name: Friedrich, Thomas
name: Wegner, Franz
name: Buzug, Thorsten
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2020

description: Minimally invasive endovascular interventions play an important role in clinical practice. The procedures are a versatile tool to physicians and are therefore also important for the development of devices and imaging systems, which leads to a high demand for preclinical evaluation. This work focuses on the feasibility of 3D-printing for vessel phantoms with user defined stenoses made of elastic materials.
description: Transactions on Additive Manufacturing Meets Medicine, Vol 2 No 1 (2020): Trans. AMMM
The Mental Health Impacts of Community Gardening and Urban Farming in a Diverse, Urban City
Creators: name: Ho, Kristi
name: Lam, Thuy L.
Publisher: name: Brandeis University
Year: 2022
Subjects: community gardening
urban agriculture
intervention
farming
Community Health
Mental Health
Public Health

description: Background: The burden of mental illness remains a public health problem that continues to grow. Research into the benefits of community gardening and urban farming (CG/UF) primarily focuses on physical health benefits, but there is less understood about the mental health benefits among racial/ethnic minorities, especially among those who tend to experience longer and more severe cases of mental illness. Examining the participants from Everett Community Growers (ECG), a local non-profit, this study aims to explore the mental health impacts of CG/UF among racially/ethnically diverse residents, identify the mechanisms involved, and finally to provide ECG feedback on ways to improve their programming.
Materials & Methods: Nineteen participants completed an online questionnaire assessing the quantitative mental health impacts of CG/UF, and seven interview participants were recruited from the survey in order to understand the pathways to positive mental health. Exact logistic regression models were used to determine whether the length of ECG participation and frequency of garden/farm visits were associated with the presence of anxiety and depressive symptoms. Interview data were analyzed using thematic analysis based on grounded theory. 
Results: For each additional year a grower participated with ECG, there was a 33% higher odds of anxiety/depression symptoms after adjusting for race, gender, and income, (OR = 1.33, 95% CI [0.88, 3.24] p = 0.19) compared to growers that participated fewer years. There was an 11% higher odds of anxiety/depression symptoms based on the frequency of garden/farm visits after adjusting for covariates (OR = 1.12, 95% CI [0.46, 2.99], p = 0.93. From our qualitative interviews, CG/UF appears to contribute to an overall positive impact on mental health with specific themes focused on time spent outdoors, social interactions, and positive emotions from the process of gardening. Feedback from ECG participants indicated a desire for more social gatherings and learning opportunities (e.g., gardening and cooking workshops).
Summary and Significance: Based on qualitative interviews, CG/UF may serve as a culturally relevant mental health promotion method for racially/ethnically diverse populations. Furthermore, other urban agriculture programs can consider tailoring their programming to best support their growers and allow opportunities for social interactions to reap the mental health benefits. Findings highlight the need for establishing additional zoning regulations for urban agriculture to expand the benefits of CG/UF programs.
3D selective laser glass etching for medical applications
Creators: name: Butkute, Agne
name: Baravykas, Tomas
name: Tičkūnas, Titas
name: Jonušauskas, Linas
name: Sirutkaitis, Valdas
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2020

description: Glass is one of the most common materials in medicine. It is used due to being biologically inert, having excellent optical transparency and possibility to handle it easily. However, there are severe limitations in processing glass structures in 3D fashion at µm scale. In this work we present femtosecond laser-based selective glass etching as an attractive tool to produce medical glass structures. We discuss how it can be used to create various microfluidical and micromechanical systems. The challenges and capabilities related to the technology are highlighted, comparing it to other additive manufacturing techniques.
description: Transactions on Additive Manufacturing Meets Medicine, Vol 2 No 1 (2020): Trans. AMMM
EPIDEMIOLOGY OF VASOMOTOR RHINITIS (NONALLERGIC RHINITIS) IN PATIENTS WITH THYROTOXICOSIS
Creators: name: Muminov, S.Kh.
Publisher: name: Zenodo
Year: 2025

description: During recent years, clinicians have investigated extensively the causative factors in vasomotor rhinitis, more particularly the seasonal vasomotor rhinitis or so-called hay-fever. There is, however, a group of cases in which this type of symptoms continues throughout the year, without a definite seasonal activity. With thyroid dysfunction, a number of significant deviations from the physiological norm are observed on the part of the ENT organs, which indicates the influence of thyroid hormones on the functional state of the upper respiratory tract. The purpose of this review is to study the effect of thyrotoxicosis on the course of vasomotor rhinitis. The review material included scientific publications over the past 10 years, published in the international databases E-library, Scopus and Web of Science. Thus, it follows that the study of the features of the clinical course and treatment of vasomotor rhinitis associated with thyrotoxicosis is of particular importance.
Moralesonia australis D. M. Williams, Ts. Georgiev, T. M. Schust. & C. E. Wetzel 2024, sp. nov.
Creators: name: Williams, David M.
name: Georgiev, Tsvetoslav
name: Schuster, Tanja M.
name: Wetzel, Carlos E.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Sapindales
Rutaceae
Moralesonia
Moralesonia australis

description: Moralesonia australis D. M. Williams, Ts. Georgiev, T. M. Schust. & C. E. Wetzel sp. nov.
Fig. 7
Type locality.
Australia, Carpentaria Bay (Arafura sea), BM 12829! (= Fig. 7 E – F), holotype (= Cleve & Möller Diatoms [no.] 61, “ Carpentaria Bay ”, as Euodia Fraunfeldii Grunow), and BM Adams ‘ Cleve & Möller [no.] 61 ’!, isotype. BM 31718! [Comber 927], “ Carpentaria Golf ”, Australia, J. D. Möller [no. 896, 1889]; BM 6481! (‘ Euodia Fraunfeldii Grun. | Australien | J. D. Möller’, Fig. 7 G), BM 60070! (J. D. Möller ex Wynne Baxter 6992); BM 74090! (J. D. Möller ex Wise [no.] 1918, “ Australie ”); BM 26837! (as “ Eunotogramma frauenfeldii Grun. | Australie ”, Van Heurck 1885: 118, sér. XXII, no. 526 = Fig. 7 A – E) and BM Adams HVH 526!; W 0164933! (Grunow sample 1484) (J. D. Möller, “ Carpentaria Golf, Australia ”), isotype, Fig. 7 D, H – I, Grunow’s drawings, catalogue notes, and slide; BRM HB- 19–20.
Registration.
http://phycobank.org/104548
Description.
Valves lunate, occasionally fusiform, length 55–65 μm, width 20–25 μm, width ± constant, forming less convex ventral margin. Each valve with two transapical ribs dividing valve into three ± equal parts. Ribs evident externally by clear area, extending through to entire mantle, indicating it as part of valve. Internally raised by 2–3 μm, tapering towards mantle edge. Areolae ± round, radiating from eccentric hyaline centre. Rimoportulae absent. Cribra detail not visible or preserved. Girdle unknown. Species synapomorphy: large and diffuse areolae.
Notes.
It is quite possible that all the material cited above is from the same source: Carpentaria Bay (Arafura Sea), Australia, which is a reasonably large area. The notes on the material for Cleve and Möller slide no. 61 simply state “ Comm. [unicavit] I. D. Möller [= Johann Diedrich Möller] ” (Cleve and Möller 1878: 2).
description: Published as part of Williams, David M., Georgiev, Tsvetoslav, Schuster, Tanja M. & Wetzel, Carlos E., 2024, The relationships of Eunotogramma frauenfeldii (Bacillariophyta) I. An account of its structure and description of the new genus Moralesonia, pp. 270-290 in Plant Ecology and Evolution 157 (3) on pages 270-290, DOI: 10.5091/plecevo.121829
The baryonic halos of isolated elliptical galaxies
Creators: name: Salinas, Ricardo
name: Alabi, Adebusola
name: Hammar, Nicklas
name: Richtler, Tom
name: Lane, Richard R.
name: Schirmer, Mischa
Publisher: name: Swinburne
Year: 2024

description: Without the interference of a number of events, galaxies may suffer in crowded environments (e.g., stripping, harassment, strangulation); isolated elliptical galaxies provide a control sample for the study of galaxy formation. We present the study of a sample of isolated ellipticals using imaging from a variety of telescopes, focusing on their globular cluster systems as tracers of their stellar halos. Our main findings are: (a) GC color bimodality is common even in the most isolated systems; (b) the specific frequency of GCs is fairly constant with galaxy mass, without showing an increase towards high-mass systems like in the case of cluster ellipticals; (c) on the other hand, the red fraction of GCs follows the same inverted V shape trend with mass as seen in cluster ellipticals; and (d) the stellar halos show low Sérsic indices which are consistent with a major merger origin.
Supplementary document for Intelligent on-demand inverse design of high-degree-of-freedom meta-atoms: Multi-constraint-latent diffusion model and contrastive learning - 7459766.pdf
Creators: name: Zhu, Lu
name: Hua, wei
name: Lv, Cong
name: Liu, YuanYuan
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement 1
Sintering behavior of 3D printed barium titanate composite scaffolds for bone repair
Creators: name: Polley, Christian
name: Schulze, Sebastian
name: Distler, Thomas
name: Detsch, Rainer
name: Boccaccini, Aldo R.
name: Seitz, Hermann
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2020

description: Additive manufacturing of novel biomaterials with additional stimulating functions represents a promising strategy for bone repair. In this study, a systematic investigation of the necessary thermal post-treatment of 3D printed barium titanate composite ceramics to achieve the desired mechanical properties for bone regeneration is presented. The maximum sintering temperature was varied from 1320 °C to 1380 °C in 10 K intervals. After sintering, the samples were systematically characterized with respect to their porosity and mechanical properties. Specimens sintered at 1380 °C exhibit a considerably densified microstructure and improved mechanical integrity compared to specimens sintered at lower temperatures.
description: Transactions on Additive Manufacturing Meets Medicine, Vol 2 No 1 (2020): Trans. AMMM
Three essays evaluating how policies expanding access to Medicaid dental services impact early detection of oral cancer in low-income adults
Creators: name: Semprini, Jason
Publisher: name: University of Iowa
Year: 2025
Subjects: subject: Causal Inference
subject: Dental
subject: Medicaid
subject: Policy
subject: public abstract
subject: Econometrics
subject: FOS: Economics and business
subject: Oral Cancer
subject: Public Health

description: Every year in America, over 10,000 adults die from oral cancer. This disease primarily affects lower income adults. While there are differences by socioeconomic and Human Papillomavirus (HPV) status, the stage at diagnosis is an important factor for patient outcomes. Earlier detection of oral cancer is associated with longer survival, lower treatment costs, and better quality of life. Unfortunately, less than 30% of oral cancers are detected early and evidence for improving early detection has been limited. The first study analyzes nationally representative oral cancer screening data to determine if the ACA increased oral cancer screening rates for physicians or dentists. Before and after the ACA, low-income adults had the lowest prevalence of oral cancer screenings. However, the ACA was associated with higher oral cancer screenings for low-income adults, but only for screenings performed by dentists. The second study reexamines the effect of Medicaid expansion on early detection of oral cancer in states offering Medicaid dental benefits. We found that expanding Medicaid eligibility was associated with a decrease in late-stage diagnoses, but only for HPV(-) oral cancers in states which added Medicaid dental benefits. The third study evaluated California’s decision to drop Medicaid dental benefits. Among Medicaid patients diagnosed with non-oropharyngeal HPV(-) oral cancer, dropping Medicaid dental benefits was associated with a decline in early-stage diagnoses. This effect was highest in counties with more available dentists. Unequal access to Medicaid dental coverage and provider shortages delays oral cancer detection. Alternative approaches are needed to promote early detection of HPV+ oral cancer.
Structural Static Characterization of a Novel 3D Printed Prosthetic Foot
Creators: name: Porras, Fabian
name: Araya, Miguel
name: Sánchez, Olga
name: Vargas, Roberto
name: Corrales, Sebastián
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2020

description: The new possibilities in Additive Manufacturing allow the development and manufacture of functional, high strength, and customizable 3D printing prosthetic components. This study characterizes the structural resistance, under static loads, of a 3D printed prosthetic foot fabricated with additive manufacturing of continuous filament deposition. Two conditions (keel and heel tests) were evaluated according to the standard ISO 22675. Peak forces of 4106 N were applied to the prosthetic foot with a maximum deformation of 40.8 mm, as a result, no visible fractures were found and total shape recovery.
description: Transactions on Additive Manufacturing Meets Medicine, Vol 2 No 1 (2020): Trans. AMMM