cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Estimation of coronary artery calcification score in non-ECG gated CT
Creators: name: Masajada, Anna
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Cardiac
subject: Cardiovascular system
subject: CT
subject: Screening
subject: Calcifications / Calculi

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Cardiovascular disease is currently the leading cause of death worldwide [1]. Coronary artery calcium (CAC) is characteristic of coronary artery disease and its assessment enables the stratification of coronary risk. The standard method for the...
title: A prevalence study of spinal inflammation lesions as detected by sacroiliac joints (SIJs) MRI: preliminary reports.
Creators: name: Di Meglio, Nunzia
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Musculoskeletal joint
subject: Musculoskeletal spine
subject: MR
subject: Diagnostic procedure
subject: Education
subject: Experimental investigations
subject: Education and training

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Establishing a diagnosis for axial spondylarthritis (axSpA) is based on the combined presence of several clinical and laboratory features in association with imaging ( Fig.1 ). In patients with chronic low back pain (LBP) of more than 3 months’...
title: Viro clarissimo eruditissimo meritissimo summa reverentia colendo Friderico Münscher philosophiae doctori directori gymnasii Marburgensis equiti ordinis IV aquilae rubrae ...
Creators: name: Schimmelpfeng, Gustav
name: Rothfuchs, Julius
Publisher: name: Philipps-Universität Marburg
Year: 2025
Subjects: Generalities, Science
Allgemeines, Wissenschaft
Festschrift

description: Elektronische Reproduktion von: Viro clarissimo eruditissimo meritissimo summa reverentia colendo Friderico Münscher philosophiae doctori directori gymnasii Marburgensis equiti ordinis IV aquilae rubrae ... diem auspicatissimum a.d. X. Cal. Mai. MDCCCLXXXIII quo ante quinquaginta annos primum suscepit munus scholasticum rite celebranti gratulabundi et venerabundi ... / nuncupant Gustav Schimmelpfeng Ilfeldensis ; Julius Rothfuchs Guterslohensis. - Körperschaft: Franckesche Stiftungen zu Halle. Waisenhaus [Drucker]. - 
Halis Saxonum : Typis Orphanotrophei, [1883]. - 11 ungezählte Seiten ; 4°. - 
Standort: Universität Marburg, Universitätsbibliothek. - 
Signatur: VIII B 331 db, 16. - 
Bemerkungen: Text in deutsch, lateinisch und griechisch in griechischer Schrift. - 
Titel- und Texteinrahmung in Rotdruck. - 
Festschrift zum 50jährigen Amtsjubiläum Münschers. - 
Die Rückseite des Titelblatts ist unbedruckt. - 
(Hassiaca)

Digitalisiert 2024
title: Useful glossary terms in radiology management
Creators: name: Villaquirán, Susana
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Management
subject: PACS
subject: Cost-effectiveness
subject: Health policy and practice
subject: Economics

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: The aim of this study is to know, to understand and apply, appropiately, the most frequent terms used in management processes, in radiology...
title: Creating and Sustaining a National Quality and Safety Network for Italian National Federation of Radiographers and Technical, Rehabilitation and Prevention Health Professions
Creators: name: Migliorini, Matteo
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Management
subject: Plain radiographic studies
subject: Safety
subject: Workforce

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Although debate continues over estimates of the amount of preventable medical harm that occurs in health care, there seems to be a consensus that health care is not as safe and reliable as it might be. It is often assumed that copying and adapting...
(401318) Margaret Maxwell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Positive Inotropic Effects by Uridine Triphosphate (UTP) and Uridine Diphosphate (UDP) via P2Y2 and P2Y6 Receptors on Cardiomyocytes and Release of UTP in Man During Myocardial Infarction
Creators: name: Borna, Catharina
name: Wang, Lingwei
name: Dou, Ying
name: Balogh, Johanna
name: Erlinge, David
name: Arner, Anders
name: Jacobson, Kenneth A.
name: Wihlborg, Anna Karin
name: Joshi, Bhalchandra V.
name: Lazarowski, Eduardo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: The aim of this study was to examine a possible role for extracellular pyrimidines as inotropic factors for the heart. First, nucleotide plasma levels were measured to evaluate whether UTP is released in patients with coronary heart disease. Then, inotropic effects of pyrimidines were examined in isolated mouse cardiomyocytes. Finally, expression of pyrimidine-selective receptors (a subgroup of the P2 receptors) was studied in human and mouse heart, using real time polymerase chain reaction, Western blot, and immunohistochemistry. Venous plasma levels of UTP were increased (57%) in patients with myocardial infarction. In electrically stimulated cardiomyocytes the stable P2Y2/4 agonist UTPγS increased contraction by 52%, similar to β1-adrenergic stimulation with isoproterenol (65%). The P2Y6-agonist UDPγS also increased cardiomyocyte contraction (35%), an effect abolished by the P2Y6-blocker MRS2578. The phospholipase C inhibitor {"type":"entrez-nucleotide","attrs":{"text":"U73122","term_id":"4098075","term_text":"U73122"}}U73122 inhibited both the UDPγS and the UTPγS-induced inotropic effect, indicating an IP3-mediated effect via P2Y6 receptors. The P2Y14 agonist UDP-glucose was without effect. Quantification of mRNA with real time polymerase chain reaction revealed P2Y2 as the most abundant pyrimidine receptor expressed in cardiomyocytes from man. Presence of P2Y6 receptor mRNA was detected in both species and confirmed at protein level with Western blot and immunohistochemistry in man. In conclusion, UTP levels are increased in humans during myocardial infarction, giving the first evidence for UTP release in man. UTP is a cardiac inotropic factor most likely by activation of P2Y2 receptors in man. For the first time we demonstrate inotropic effects of UDP, mediated by P2Y6 receptors via an IP3-dependent pathway. Thus, the extracellular pyrimidines (UTP and UDP) could be important inotropic factors involved in the development of cardiac disease.
Role of Soluble Epoxide Hydrolase in Postischemic Recovery of Heart Contractile Function
Creators: name: Roberts, Holly
name: Carey, Michelle A.
name: Hammock, Bruce D.
name: Seubert, John M.
name: Sinal, Christopher J.
name: Goralski, Kerry
name: Zeldin, Darryl C.
name: Newman, John W.
name: Murphy, Elizabeth
name: Lee, Craig R.
name: Graves, Joan
name: Degraff, Laura M.
name: Bradbury, J. Alyce
name: Falck, John R.
name: Rockman, Howard A.
name: Luria, Ayala
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Cytochrome P450 epoxygenases metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs) which are converted to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (Ephx2, sEH). To examine the functional role of sEH in the heart, mice with targeted disruption of the Ephx2 gene were studied. Hearts from sEH null mice have undetectable levels of sEH mRNA and protein and cannot convert EETs to DHETs. sEH null mice have normal heart anatomy and basal contractile function, but have higher fatty acid epoxide:diol ratios in plasma and cardiomyocyte cell culture media compared with wild type (WT). sEH null hearts have improved recovery of left ventricular developed pressure (LVDP) and less infarction compared with WT hearts after 20 minutes ischemia. Perfusion with the putative EET receptor antagonist 14,15-epoxyeicosa-5(Z)-enoic acid (10 to 100 nmol/L) before ischemia abolishes this cardioprotective phenotype. Inhibitor studies demonstrate that perfusion with phosphatidylinositol-3 kinase (PI3K) inhibitors wortmannin (200 nmol/L) or LY294002 (5 μmol/L), the ATP-sensitive K+ channel (KATP) inhibitor glibenclamide (1 μmol/L), the mitochondrial KATP (mitoKATP) inhibitor 5-hydroxydecanoate (100 to 200 μmol/L), or the Ca2+-sensitive K+ channel (KCa) inhibitor paxilline (10 μmol/L) abolishes the cardioprotection in sEH null hearts. Consistent with increased activation of the PI3K cascade, sEH null mice exhibit increased cardiac expression of glycogen synthase kinase-3β (GSK-3β) phospho-protein after ischemia. Together, these data suggest that targeted disruption of sEH increases the availability of cardioprotective EETs that work by activating PI3K signaling pathways and K+ channels.
Additional file 1 of Measuring commissioners’ willingness-to-pay for community based childhood obesity prevention programmes using a discrete choice experiment
Creators: name: Webb, Edward J. D.
name: Stamp, Elizabeth
name: Collinson, Michelle
name: Farrin, Amanda J.
name: Stevens, June
name: Burton, Wendy
name: Rutter, Harry
name: Schofield, Holly
name: Bryant, Maria
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: Computational Biology

description: Additional file 1. Survey statistical design, model estimation, calculating willingness to pay for real world programmes.
(401314) Albert Edward Dixon
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Brothers and Sisters: Molecular Insights Into Arterial-Venous Heterogeneity
Creators: name: Portbury, Andrea L.
name: Schisler, Jonathan C.
name: Aitsebaomo, Julius
name: Patterson, Cam
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The molecular differences between arteries and veins are genetically predetermined and are evident even before the first embryonic heart beat. Although ephrinB2 and EphB4 are expressed in cells that will ultimately differentiate into arteries and veins respectively, many other genes have been shown to play a significant role in cell fate determination. The expression patterns of ephrinB2 and EphB4 are restricted to arterial-venous boundaries, and Eph/ephrin signaling provides repulsive cues at arterial-venous boundaries that are thought to prevent intermixing of arterial- and venous-fated cells. However, the maintenance of arterial-venous fate is susceptible to some degree of plasticity. Thus, in response to signals from the ambient microenvironment and shear stress, there is flow-mediated intercalation of the arteries and veins that ultimately leads to the formation of a functional, closed-loop circulation. In addition, cells in the blood vessels of each organ undergo epigenetic, morphologic and functional adaptive changes that are specific to the proximate function of their cognate organ(s). These adaptive changes result in an inter-organ and intra-organ vessel heterogeneity that manifest clinically in a disparate response of different organs to identical risk factors and injury in the same animal. In this review, we will focus on the molecular and physiologic factors influencing arterial-venous heterogeneity between and within different organ(s). We will explore arterial-venous differences in selected organs as well as their respective endothelial cell architectural organization that results in their inter- and intra-organ heterogeneity.
Heparin-Binding Epidermal Growth Factor-Like Growth Factor Signaling in Flow-Induced Arterial Remodeling
Creators: name: Faber, James E.
name: Zhang, Hua
name: McNaughton, K. Kirk
name: Johns, Terrance G.
name: Lee, David C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Heparin-binding EGF-like growth factor (HB-EGF) is activated by reduced endothelial shear stress and stimulates smooth muscle cell (SMC) proliferation in vitro. More- over, HB-EGF is augmented at sites of intimal hyperplasia and atherosclerosis— conditions favored by low/disturbed shear stress. We thus tested whether HB-EGF contributes to low Flow-Induced NUegative hypertrophic Remodeling (FINR) of mouse carotid artery. Blood flow was surgically decreased in the left and increased in the right common carotids. After 21 days, left carotid exhibited lumen narrowing, thickening of intima-media and adventitia, and increased circumference that were inhibited by ~50% in HB-EGF+/- and ~90% in HB-EGF-/- mice. FINR was also inhibited by the EGF receptor inhibitor, AG1478. In contrast, eutrophic outward remodeling of the right carotid was unaffected in HB-EGF+/- and HB-EGF-/- mice or by AG1478. FINR-induced proliferation and leukocyte accumulation were reduced in HB-EGF-/-. FINR was associated with increased: reactive oxygen species, expression of pro-HB-EGF and TACE (pro-HB-EGF sheddase), phosphorylation of EGFR and Erk1/2, and NF-κB activity. Apocynin and deletion of p47phox inhibited FINR, while deletion of HB-EGF abolished NF-κB activation in SMCs. These findings suggest that HB-EGF signaling is required for low flow-induced hypertrophic remodeling and may participate in vascular wall disease and remodeling.
(401316) Gilbert Sutherland McDowell Elliott
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Intraorbital foreign bodies: A radiological point of view
Creators: name: Klemencic, Antonio
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Eyes
subject: CT
subject: MR
subject: Diagnostic procedure
subject: Acute
subject: Foreign bodies
subject: Trauma

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To give the pictorial examples and radiological features of the most common types of intraorbital foreign bodies...
Radiative Linear Seesaw model, Dark Matter and $U(1)_{B-L}$
Creators: name: Wang, Weijian
name: Han, Zhi-Long
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this paper we propose a radiated linear seesaw model where the naturally small term $μ_{L}$ are generated at one-loop level and its soft-breaking of lepton number symmetry attributes to the spontaneous breaking(SSB) of B-L gauge symmetry. The value of $B-L$ charges for new particles are assigned to satisfy the anomalies cancelation. It is founded that some new particles may have exotic values of $B-L$ charge such that there exists residual $Z_{2}\times Z_{2}^{\prime}$ symmetry even after SSB of $B-L$ gauge symmetry. The $Z_{2}\times Z_{2}^{\prime}$ discrete symmetry stabilizes the these particles as dark matter candidates. In the model, two classes of inert fermions and scalars with different $B-L$ charges are introduced, leading to two-component dark matter candidates. The lepton flavor violation processes, the relic density of dark matter, the direct detection of dark matter and the phenomenology at LHC are investigated.
description: 23 pages, 13 figures, more discussions and references are added, published in PRD
title: CT and MRI of cerebellopontine angles: What radiologist should know?
Creators: name: Klemencic, Antonio
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Head and neck
subject: Oncology
subject: CT
subject: MR
subject: Diagnostic procedure
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To present the anatomy of cerebellopontine angles (CPA) as well as clinical features and radiological appearance of the most common cerebellopontine angle...
Localized  4 Integrin Phosphorylation Directs Shear Stress-Induced Endothelial Cell Alignment
Creators: name: Tkachenko, Eugene
name: Tzima, Eleni
name: Nguyen, Phu
name: Goldfinger, Lawrence E.
name: Chien, Shu
name: Groisman, Alex
name: Kiosses, William B.
name: Kinbara, Kayoko
name: Gutierrez, Edgar
name: Ginsberg, Mark H.
name: Stockton, Rebecca
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Vascular endothelial cells respond to laminar shear stress by aligning in the direction of flow, a process which may contribute to athero-protection. Here we report that localized α4 integrin phosphorylation is a mechanism for establishing the directionality of shear stress-induced alignment in microvascular endothelial cells. Within 5 minutes of exposure to a physiological level of shear stress, endothelial α4 integrins became phosphorylated on Ser988. In wounded monolayers, phosphorylation was enhanced at the downstream edges of cells relative to the source of flow. The shear-induced α4 integrin phosphorylation was blocked by inhibitors of cAMP-dependent protein kinase A (PKA), an enzyme involved in the alignment of endothelial cells under prolonged shear. Moreover, shear-induced localized activation of the small GTPase Rac1, which specifies the directionality of endothelial alignment, was similarly blocked by PKA inhibitors. Furthermore, endothelial cells bearing a non-phosphorylatable α4(S988A) mutation failed to align in response to shear stress, thus establishing α4 as a relevant PKA substrate. We thereby show that shear-induced PKA-dependent α4 integrin phosphorylation at the downstream edge of endothelial cells promotes localized Rac1 activation, which in turn directs cytoskeletal alignment in response to shear stress.
(401312) Piercy Griffith Bruce-Austin
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Lysophosphatidic Acid Receptors 1 and 2 Play Roles in Regulation of Vascular Injury Responses but Not Blood Pressure
Creators: name: Rojas, Mauricio
name: Yang, Fanmuyi
name: Dong, Anping
name: Smyth, Susan S.
name: Miriyala, Sumitra
name: Lynch, Kevin
name: Chun, Jerold
name: Vallant, Christopher
name: Panchatcharam, Manikandan
name: End, Christopher
name: Morris, Andrew J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Phenotypic modulation of vascular smooth muscle cells (SMC) is essential for the development of intimal hyperplasia. Lysophosphatidic acid (LPA) is a serum component that can promote phenotypic modulation of cultured SMC, but an endogenous role for this bioactive lipid as a regulator of SMC function in vivo has not been established. Ligation injury of the carotid artery in mice increased levels in the vessel of both autotaxin, the lysophospholipaseD enzyme responsible for generation of extracellular LPA, and two LPA responsive G-protein coupled receptors 1 (LPA1) and 2 (LPA2). LPA1-/-2-/- mice were partially protected from the development of injury-induced neointimal hyperplasia, whereas LPA1-/- mice developed larger neointimal lesions after injury. Growth in serum, LPA-induced ERK activation, and migration to LPA and serum were all attenuated in SMC isolated from LPA1-/-2-/- mice. In contrast, LPA1-/- SMCs exhibited enhanced migration resulting from an upregulation of LPA3. However, despite their involvement in intimal hyperplasia, neither LPA1 nor LPA2 were required for dedifferentiation of SMC following vascular injury or dedifferentiation of isolated SMC in response to LPA or serum in vitro. Similarly, neither LPA1 nor LPA2 were required for LPA to elicit a transient increase in blood pressure following intravenous administration of LPA to mice. These results identify a role for LPA and two defined LPA receptors in regulating SMC migratory responses in the context of vascular injury, but suggest that additional LPA receptor subtypes are required for other LPA-mediated effects in the vasculature.
title: Trauergesang am Grabe unsers unvergeßlichen Lehrers Herrn Prorektors Wilhelm Münscher
Creators: name: Schulz, Thomas
Publisher: name: Philipps-Universität Marburg
Year: 2025
Subjects: Generalities, Science
Allgemeines, Wissenschaft
Festschrift

description: Elektronische Reproduktion von: Trauergesang am Grabe unsers unvergeßlichen Lehrers Herrn Prorektors Wilhelm Münscher : aus Dankbarkeit gewidmet / von Seinem Schüler Thomas Schulz, Studiosus der Theologie, a.d. Grafschaft Mark. - Marburg, 1814. - [4] Blätter. - 
Standort: Universität Marburg, Universitätsbibliothek. - 
Signatur: VIII B 331 db, 16. - 
Bemerkungen: In Fraktur. - 
Umlaute mit übergestelltem "e" dargestellt. - 
(Hassiaca)

Digitalisiert 2024
Cosmic anisotropic doomsday in Bianchi type I universes
Creators: name: Cataldo, Mauricio
name: Cid, Antonella
name: Labraña, Pedro
name: Mella, Patricio
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In order to investigate if the anisotropy of the spacetime may induce future singularities at a finite value of the cosmic time on the evolution of cosmological models, we study vacuum and non-vacuum Bianchi type I spacetimes exhibiting such future singularities. We show that in the case of Kasner vacuum cosmologies the spacetime may rip itself apart in a finite time, and only in the direction corresponding to the unique scale factor which diverges at this finite value of the cosmic time. The other two directional scale factors and the average scale factor do not diverge and tend to zero at this time, while the directional and average expansion rates also become infinite. Due to the absence of the matter content this anisotropic future singularity is induced by the shear scalar, which also blows up at this time. We call such a singularity "Vacuum Rip". For non-vacuum solutions we discuss fully anisotropic Bianchi type I spacetimes filled with a stiff fluid and ellipsoidal (axisymmetric) cosmological models filled with matter with isotropic and anisotropic barotropic pressure, and characterized by $σ/θ=const$, where $σ$ and $θ$ are the shear scalar and the expansion scalar respectively.
description: 10 pages, 6 figures, Accepted for publication in Journal of Mathematical Physics (2016)
The LIM Protein Leupaxin Is Enriched in Smooth Muscle and Functions As an Serum Response Factor Cofactor to Induce Smooth Muscle Cell Gene Transcription
Creators: name: MacK, Christopher P.
name: Sayers, Rebecca L.
name: Taylor, Joan M.
name: Sundberg-Smith, Liisa J.
name: Dimichele, Laura A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Leupaxin is a LIM-domain containing adapter protein belonging to the paxillin family that has been previously reported to be preferentially expressed in hematopoeitic cells. Herein, we identified leupaxin in a screen for FAK binding partners in aortic smooth muscle, show that leupaxin is enriched in human and mouse vascular smooth muscle, and that leupaxin expression is dynamically regulated during development. In addition, our studies reveal that leupaxin can undergo cytoplasmic/nuclear shuttling and functions as an SRF-cofactor in the nucleus. We found that leupaxin forms a complex with SRF, associates with CArG-containing regions of SM promoters, and that ectopic expression of leupaxin induces SM marker gene expression in both 10T1/2 cells and rat aortic smooth muscle cells (SMC). Subsequent studies indicated that enhanced FAK activity (induced by fibronectin or expression of constitutively active FAK) attenuates the nuclear accumulation of leupaxin and limits the ability of leupaxin to enhance SRF-dependent gene transcription. Thus, these studies indicate that modulation of the sub-cellular localization of SRF-cofactors is one mechanism by which extracellular matrix-dependent signals might regulate phenotypic switching of SMC.
Newton-Okounkov bodies of Bott-Samelson varieties and Grossberg-Karshon twisted cubes
Creators: name: Harada, Megumi
name: Yang, Jihyeon Jessie
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Geometry (math.AG)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics

description: We describe, under certain conditions, the Newton-Okounkov body of a Bott-Samelson variety as a lattice polytope defined by an explicit list of inequalities. The valuation that we use to define the Newton-Okounkov body is different from that used previously in the literature. The polytope that arises is a special case of the Grossberg-Karshon twisted cubes studied by Grossberg and Karshon in connection to character formulae for irreducible $G$-representations and also studied previously by the authors in relation to certain toric varieties associated to Bott-Samelson varieties.
description: 17 pages, 3 figures. References added
Cardiac Muscle Ring Finger-1 Increases Susceptibility to Heart Failure In Vivo
Creators: name: Hilliard, Eleanor G.
name: Charles, Peter C.
name: Patterson, Cam
name: Rodríguez, Jessica E.
name: Willis, Monte S.
name: Schisler, Jonathan C.
name: Li, Luge
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Muscle ring finger-1 (MuRF1) is a muscle-specific protein implicated in the regulation of cardiac myocyte size and contractility. MuRF2, a closely related family member, redundantly interacts with protein substrates, and hetero-dimerizes with MuRF1. Mice lacking either MuRF1 or MuRF2 are phenotypically normal whereas mice lacking both proteins develop a spontaneous cardiac and skeletal muscle hypertrophy indicating cooperative control of muscle mass by MuRF1 and MuRF2. In order to identify the unique role that MuRF1 plays in regulating cardiac hypertrophy in vivo, we created transgenic mice expressing increased amounts of cardiac MuRF1. Adult MuRF1 transgenic (Tg+) hearts exhibited a non-progressive thinning of the left ventricular wall and a concomitant decrease in cardiac function. Experimental induction of cardiac hypertrophy by trans-aortic constriction (TAC) induced rapid failure of MuRF1 Tg+ hearts. Microarray analysis identified that the levels of genes associated with metabolism (and in particular mitochondrial processes) were significantly altered in MuRF1 Tg+ hearts, both at baseline and during the development of cardiac hypertrophy. Surprisingly, ATP levels in MuRF1 Tg+ mice did not differ from wild type mice despite the depressed contractility following TAC. In comparing the level and activity of creatine kinase (CK) between wild type and MuRF1 Tg+ hearts we found that mCK and CK-M/B protein levels were unaffected in MuRF1 Tg+ hearts, however total CK activity was significantly inhibited. We conclude that increased expression of cardiac MuRF1 results in a broad disruption of primary metabolic functions, including alterations in CK activity that leads to increased susceptibility to heart failure following TAC. This study demonstrates for the first time a role for MuRF1 in the regulation of cardiac energetics in vivo.
title: Granulomatous Mastitis : The Great Simulator.
Creators: name: Abbes, Wejden
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Breast
subject: Mammography
subject: MR
subject: Ultrasound
subject: Abscess delineation
subject: Abscess
subject: Cancer
subject: Inflammation

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Our aim is to: Illustrate the spectrum of radiologic features seen in chronic granulomatous mastitis on mammography, ultrasound and magnetic resonance imaging (MRI). To clarify the main differential diagnosis pitfalls especially breast...
Chloride Intracellular Channel-4 Is a Determinant of Native Collateral Formation in Skeletal Muscle and Brain
Creators: name: Faber, James E.
name: Edwards, John C.
name: Chalothorn, Dan
name: Zhang, Hua
name: Smith, Jennifer E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The capacity of the collateral circulation to lessen injury in occlusive vascular disease depends on the density and caliber of native (pre-existing) collaterals, as well as their ability to outwardly remodel in ischemia. Native collateral conductance varies widely among healthy individuals, yet little is known about what specifies collateral formation. Chloride intracellular channel-4 protein (CLIC4) is required for endothelial cell hollowing, a process necessary for vessel formation during embryogenesis and ischemia. Whether CLIC4 has other physiological roles in vascular biology is uncertain. We studied collateral formation and remodeling in mice deficient in CLIC1 and CLIC4. Vascular responses to femoral artery ligation were similar in Clic1-/- and wild-type mice. In contrast, immediately after ligation perfusion dropped more in Clic4-/- than wild-type mice, suggesting fewer pre-existing collaterals—a finding confirmed by angiography, greater ischemia and worse recovery of perfusion; however, collateral remodeling was unaffected. Likewise, native cerebral collateral density in Clic4-/- (but not Clic1-/-) mice was reduced, resulting in severe infarctions. This was associated with impaired perinatal formation and stabilization of nascent collaterals. Clic4 hemizygous mice had intermediate deficits in the above parameters, suggesting a gene-dose effect. Ischemia augmented CLIC1 and CLIC4 expression similarly in wild-type mice. However, CLIC1 increased 3-fold more in Clic4-/- mice, suggesting compensation. Despite greater ischemia in Clic4-/- mice, HIF-1α, VEGF and angiopoietin-2 increased less compared to wild-type, suggesting CLIC4 exerts influences upstream of HIF-1α—VEGF signaling. Hence, CLIC4 represents the second gene that, along with VEGF shown by us previously, specifies native collateral formation.
(401313) Florence [Florry] Oldfield
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Keep an eye on the hepatic perfusion disorders
Creators: name: fahlouchi, wejdene
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Liver
subject: CT
subject: Contrast agent-intravenous
subject: Abscess
subject: Infection

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Recognizing an hepatic perfusion disorder on CT-scan. Defining CT-scan protocol for exploration of hepatic perfusion abnormalities. Understanding the different causes of hepatic perfusion...
Many-body theory of ultrafast demagnetization and angular momentum transfer in ferromagnetic transition metals
Creators: name: Töws, W.
name: Pastor, G. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Exact calculated time evolutions in the framework of a many-electron model of itinerant magnetism provide new insights into the laser-induced ultrafast demagnetization observed in ferromagnetic (FM) transition metal thin films. The interplay between local spin-orbit interactions and interatomic hopping is shown to be at the origin of the observed post-excitation breakdown of FM correlations between highly stable local magnetic moments. The mechanism behind spin- and angular-momentum transfer is revealed from a microscopic perspective by rigorously complying with all fundamental conservation laws. An energy-resolved analysis of the time evolution shows that the efficiency of the demagnetization process reaches almost 100% in the excited states.
Vortex assisted mechanism of photon counting in superconducting nanowire single photon detector revealed by external magnetic field
Creators: name: Vodolazov, D. Yu.
name: Korneeva, Yu. P.
name: Semenov, A. V.
name: Korneev, A. A.
name: Goltsman, G. N.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We use external magnetic field to probe the detection mechanism of superconducting nanowire single photon detector. We argue that the hot belt model (which assumes partial suppression of the superconducting order parameter $Δ$ across the whole width of the superconducting nanowire after absorption of the single photon) does not explain observed weak field dependence of the photon count rate (PCR) for photons with $λ$=450 nm and noticeable {\it decrease} of PCR (with increasing the magnetic field) in some range of the currents for photons with wavelengths $λ$ =450-1200 nm. Found experimental results for all studied wavelengths $λ= 450-1550$ nm could be explained by the vortex hot spot model (which assumes partial suppression of $Δ$ in the area with size smaller than the width of the nanowire) if one takes into account nucleation and entrance of the vortices to the photon induced hot spot and their pinning by the hot spot with relatively large size and strongly suppressed $Δ$.
description: 11 pages, 10 figures
(401308) Andrew Willison
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Transient Expression of FRNK Reveals Stage-Specific Requirement for Focal Adhesion Kinase Activity in Cardiac Growth
Creators: name: Sayers, Rebecca L.
name: Hakim, Zeenat S.
name: Taylor, Joan M.
name: MacK, Christopher P.
name: Rojas, Mauricio
name: Schwartz, Robert J.
name: Dimichele, Laura A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Focal adhesion kinase (FAK) is strongly activated by integrins and growth factors and is essential for embryonic development. We previously showed that the C terminus of FAK is expressed as a separate protein termed FAK-related nonkinase (FRNK) in a smooth muscle cell–selective fashion and that FRNK functions to buffer FAK-dependent signals. We now show that FRNK is also transiently expressed in the neonatal myocardium, with peak levels occurring 5 to 7 days postnatal, just before cell cycle withdrawal. Using novel mouse models, we demonstrate that cardiac-selective expression of FRNK (leading to inhibition of FAK) starting at embryonic day 10.5 leads to a severe ventricular noncompaction defect associated with reduced cardiomyocyte proliferation. Remarkably, postnatal expression of nearly identical levels of FRNK is well tolerated and does not affect viability or anabolic cardiac growth. Nonetheless, FRNK expression in the adult heart does attenuate pathological cardiac hypertrophy following aortic banding, confirming and extending our previous data that this compensatory response is blunted in FAK null hearts. Our mechanistic studies in cultured neonatal cardiomyocytes reveal that FRNK expression induces p38/p27kip-dependent cell cycle withdrawal and attenuates extracellular signal-regulated kinase–dependent hypertrophic growth. These findings indicate that dynamic expression of FRNK in the neonatal heart may function to promote cardiomyocyte quiescence in an environment that is particularly rich in growth factors and growth promoting extracellular matrices.
Weyl semimetals in optical lattices: moving and merging of Weyl points, and hidden symmetry at Weyl points
Creators: name: Hou, Jing-Min
name: Chen, Wei
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: We propose to realize Weyl semimetals in a cubic optical lattice. We find that there exist three distinct Weyl semimetal phases in the cubic optical lattice for different parameter ranges. One of them has two pairs of Weyl points and the other two have one pair of Weyl points in the Brillouin zone. For a slab geometry with (010) surfaces, the Fermi arcs connecting the projections of Weyl points with opposite topological charges on the surface Brillouin zone is presented. By adjusting the parameters, the Weyl points can move in the Brillouin zone. Interestingly, for two pairs of Weyl points, as one pair of them meet and annihilate, the originial two Fermi arcs coneect into one. As the remaining Weyl points annihilate further, the Fermi arc vanishes and a gap is opened. Furthermore, we find that there always exists a hidden symmetry at Weyl points, regardless of anywhere they located in the Brillouin zone. The hidden symmetry has an antiunitary operator with its square being $-1$.
description: 10 pages, 5 figures
Endothelial Nitric Oxide Synthase Deficiency Causes Collateral Vessel Rarefaction and Impairs Activation of a Cell Cycle Gene Network During Arteriogenesis
Creators: name: Dai, Xuming
name: Faber, James E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The collateral circulation is tissue- and life-saving in obstructive arterial disease. Disappointing outcomes in clinical trials aimed at augmenting collateral growth highlight the need for greater understanding of collateral biology.
Genetic Architecture Underlying Variation in Extent and Remodeling of the Collateral Circulation
Creators: name: Faber, James E.
name: Sealock, Robert
name: Zhang, Hua
name: Dai, Xuming
name: Wang, Shiliang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Collaterals are arteriole-to-arteriole anastomoses that connect adjacent arterial trees. They lessen ischemic tissue injury by serving as endogenous bypass vessels when the trunk of one tree becomes narrowed by vascular disease. The number and diameter (“extent”) of native (pre-existing) collaterals, plus their amount of lumen enlargement (growth/remodeling) in occlusive disease, show remarkably wide variation among inbred mouse strains (eg, C57BL/6 and BALB/c), resulting in large differences in tissue injury in models of occlusive disease. Evidence suggests similar large differences exist among healthy humans.
Global bifurcations in the two-sphere: a new perspective
Creators: name: Ilyashenko, Yulij
name: Kudryashov, Yury
name: Schurov, Ilya
Publisher: name: arXiv
Year: 2015
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: We construct an open set of structurally unstable three parameter families whose weak and so called moderate topological classification defined below has a numerical invariant that may take an arbitrary positive value. Here and below "families" are "families of vector fields in the two-sphere". This result disproves an Arnold's conjecture of 1985. Then we construct an open set of six parameter families whose moderate topological classification has a functional invariant. This invariant is an arbitrary germ of a smooth map $(\mathbb R_+, a)\to(\mathbb R_+, b)$. More generally, for any positive integers $d$ and $d'$, we construct an open set of families whose topological classification has a germ of a smooth map $\left(\mathbb R_+^d, a\right)\to\left(\mathbb R_+^{d'}, b\right)$ as an invariant. Any smooth germ of this kind may be realized as such an invariant. These results open a new perspective of the global bifurcation theory in the two sphere. This perspective is discussed at the end of the paper.
Myocardial Lineage Development
Creators: name: Conlon, Frank L.
name: Yelon, Deborah
name: Evans, Sylvia M.
name: Kirby, Margaret L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The myocardium of the heart is composed of multiple highly specialized myocardial lineages, including those of the ventricular and atrial myocardium, and the specialized conduction system. Specification and maturation of each of these lineages during heart development is a highly ordered, ongoing process involving multiple signaling pathways and their intersection with transcriptional regulatory networks. Here, we attempt to summarize and compare much of what we know about specification and maturation of myocardial lineages from studies in several different vertebrate model systems. To date, most research has focused on early specification, and while there is still more to learn, less is known about factors that promote subsequent maturation of myocardial lineages required to build the functioning adult heart.
Role of PECAM-1 in Arteriogenesis and Specification of Preexisting Collaterals
Creators: name: Tzima, Ellie
name: Rubin, Janet
name: Chen, Zhongming
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Hemodymic forces caused by the altered blood flow in response to an occlusion lead to the induction of collateral remodeling and arteriogenesis. Previous work showed that platelet endothelial cell adhesion molecule-1 (PECAM-1) is a component of a mechanosensorycomplex that mediates endothelial cell (EC) responses to shearstress.
Sent to Destroy: The Ubiquitin Proteasome System Regulates Cell Signaling and Protein Quality Control in Cardiovascular Development and Disease
Creators: name: Willis, Monte S.
name: Patterson, Cam
name: Townley-Tilson, W. H.Davin
name: Kang, Eunice Y.
name: Homeister, Jonathon W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The ubiquitin proteasome system (UPS) plays a crucial role in biological processes integral to the development of the cardiovascular system and cardiovascular diseases. The UPS prototypically recognizes specific protein substrates and places polyubiquitin chains on them for subsequent destruction by the proteasome. This system is in place to degrade not only misfolded and damaged proteins, but is essential also in regulating a host of cell signaling pathways involved in proliferation, adaptation to stress, regulation of cell size, and cell death. During the development of the cardiovascular system, the UPS regulates cell signaling by modifying transcription factors, receptors, and structural proteins. Later, in the event of cardiovascular diseases as diverse as atherosclerosis, cardiac hypertrophy, and ischemia reperfusion injury, ubiquitin ligases and the proteasome are implicated in protecting and exacerbating clinical outcomes. However, when misfolded and damaged proteins are ubiquitinated by the UPS, their destruction by the proteasome is not always possible due to their aggregated confirmations. Recent studies have discovered how these ubiquitinated misfolded proteins can be destroyed by alternative “specific” mechanisms. The cytosolic receptors p62, NBR, and HDAC6 recognize aggregated ubiquitinated proteins and target them for autophagy in the process of “selective autophagy”. Even the ubiquitination of multiple proteins within whole organelles that drive the more general macro-autophagy may be due, in part, to similar ubiquitin-driven mechanisms. In summary, the cross-talk between the UPS and autophagy highlight the pivotal and diverse roles the UPS plays in maintaining protein quality control and regulating cardiovascular development and disease.