title: ÐÐµÐ¿ÑÐ¸Ð´Ñ Ð¸ Ð³ÐµÐ½Ð¾Ð¼: Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½ÑÐµ Ð¼ÐµÑ Ð°Ð½Ð¸Ð·Ð¼Ñ Ð½ÐµÐ¹ÑÐ¾Ð¿ÑÐ¾ÑÐµÐºÑÐ¸Ð¸
title: Ð¼Ð¾Ð½Ð¾Ð³ÑÐ°ÑÐ¸Ñ
titleType: Subtitle
title: Peptides and genome: molecular mechanisms of neuroprotection
Creators: name: ÐÐ¾Ð¿Ð¾Ð²Ð¸Ñ, ÐÑÐ¸Ð½Ð°
name: Ð ÑÐ¶Ð°Ðº, ÐÐ°Ð»Ð¸Ð½Ð°
name: ÐÐµÑÑÑÐ¾Ð², ÐÐ¸ÑÐ°Ð¸Ð»
name: ÐÐ¸Ð½ÑÐºÐ¾Ð²Ð°, ÐÐ°ÑÐ°Ð»ÑÑ
name: ÐÐ¾Ð¶ÐµÐ²Ð½Ð¸ÐºÐ¾Ð²Ð°, ÐÐºÐ°ÑÐµÑÐ¸Ð½Ð°
name: ÐÐ¸ÑÐ¾Ð½Ð¾Ð²Ð°, ÐÐºÐ°ÑÐµÑÐ¸Ð½Ð°
name: ÐÑÐ°ÑÐºÐ¾Ð²ÑÐºÐ°Ñ, ÐÐ¸Ð½Ð°
name: ÐÐ»ÑÐ¸Ð½Ð°, ÐÐ½Ð°ÑÑÐ°ÑÐ¸Ñ
name: ÐÐ¾ÑÑÑÐºÐ¾, ÐÐ¸Ð½Ð°
Publisher: name: ÐÐÐÐÐ¢ÐÐ¥-ÐÐ ÐÐ¡Ð¡
Year: 2022
Subjects: ÐÐµÐ¿ÑÐ¸Ð´Ñ
ÐÐ¾Ð»ÐµÐºÑÐ»ÑÑÐ½Ð°Ñ Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸Ñ

description: ÐÑÐ¸Ð²ÐµÐ´ÐµÐ½Ñ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¼Ð½Ð¾Ð³Ð¾Ð»ÐµÑÐ½Ð¸Ñ ÑÐ¾Ð²Ð¼ÐµÑÑÐ½ÑÑ Ð½Ð°ÑÑÐ½ÑÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¹ ÑÐ¾ÑÑÑÐ´Ð½Ð¸ÐºÐ¾Ð² Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¾Ð³Ð¾ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑÐ° ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾ (Ð¡ÐÐ±ÐÐ£), Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¾Ð³Ð¾ Ð¸Ð½ÑÑÐ¸ÑÑÑÐ° Ð±Ð¸Ð¾ÑÐµÐ³ÑÐ»ÑÑÐ¸Ð¸ Ð¸ Ð³ÐµÑÐ¾Ð½ÑÐ¾Ð»Ð¾Ð³Ð¸Ð¸ Ð¸ ÐÐ½ÑÑÐ¸ÑÑÑÐ° ÑÐ¸Ð·Ð¸Ð¾Ð»Ð¾Ð³Ð¸Ð¸ Ð¸Ð¼. Ð. Ð. ÐÐ°Ð²Ð»Ð¾Ð²Ð° Ð ÐÐ. ÐÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ð° Ð½Ð¾Ð²Ð°Ñ Ð³ÑÑÐ¿Ð¿Ð° Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸ Ð°ÐºÑÐ¸Ð²Ð½ÑÑ (Ð½ÐµÐ¹ÑÐ¾Ð¿ÑÐ¾ÑÐµÐºÑÐ¾ÑÐ½ÑÑ) Ð¿ÐµÐ¿ÑÐ¸Ð´Ð¾Ð² Ð¸ Ð¸Ñ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ Ð¿ÑÐ¸ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ð¸ Ð² ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð¼Ð¾Ð´ÐµÐ»ÑÑ. ÐÐ·ÑÑÐµÐ½Ñ Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½ÑÐµ Ð¼ÐµÑÐ°Ð½Ð¸Ð·Ð¼Ñ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð¿ÐµÐ¿ÑÐ¸Ð´Ð¾Ð². ÐÐ¿ÐµÑÐ²ÑÐµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð° in silico Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½Ð¾ÑÑÑ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ ÐºÐ¾ÑÐ¾ÑÐºÐ¸Ñ Ð¿ÐµÐ¿ÑÐ¸Ð´Ð¾Ð² Ñ ÐÐÐ, Ð³Ð¸ÑÑÐ¾Ð½Ð¾Ð²ÑÐ¼Ð¸ Ð±ÐµÐ»ÐºÐ°Ð¼Ð¸ Ð¸ Ð½ÑÐºÐ»ÐµÐ¾ÑÐ¾Ð¼Ð¾Ð¹. ÐÐµÐ¹ÑÐ¾Ð¿ÑÐ¾ÑÐµÐºÑÐ¾ÑÐ½ÑÐµ ÑÑÐ¸Ð¿ÐµÐ¿ÑÐ¸Ð´Ñ Ð¿ÑÐµÐ´Ð¾ÑÐ²ÑÐ°ÑÐ°ÑÑ Ð¿Ð¾ÑÐµÑÑ ÑÐ¸Ð½Ð°Ð¿ÑÐ¸ÑÐµÑÐºÐ¸Ñ ÐºÐ¾Ð½ÑÐ°ÐºÑÐ¾Ð² Ð² Ð¼Ð¾Ð´ÐµÐ»ÑÑ Ð½ÐµÐ¹ÑÐ¾Ð´ÐµÐ³ÐµÐ½ÐµÑÐ°ÑÐ¸Ð²Ð½ÑÑ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ð¹. ÐÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ñ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¹ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÐºÐ¾ÑÐ¾ÑÐºÐ¸Ñ Ð¿ÐµÐ¿ÑÐ¸Ð´Ð¾Ð² Ð¿Ð¾ Ð²Ð¾ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð¸Ñ Ð¼Ð¾ÑÑÐ¾ÑÑÐ½ÐºÑÐ¸Ð¾Ð½Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ ÑÐ¾ÑÑÐ¾ÑÐ½Ð¸Ñ Ð½ÐµÐ¹ÑÐ¾Ð½Ð½ÑÑ ÑÐµÑÐµÐ¹ Ð² Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð±Ð¾Ð»ÐµÐ·Ð½Ð¸ ÐÐ»ÑÑÐ³ÐµÐ¹Ð¼ÐµÑÐ° in vivo.
ÐÑÐµÐ´Ð½Ð°Ð·Ð½Ð°ÑÐµÐ½Ð° Ð´Ð»Ñ ÑÐ¿ÐµÑÐ¸Ð°Ð»Ð¸ÑÑÐ¾Ð² Ð² Ð¾Ð±Ð»Ð°ÑÑÐ¸ Ð¼ÐµÐ´Ð¸ÑÐ¸Ð½Ñ, Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½Ð¾Ð¹ Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸Ð¸, Ð³ÐµÐ½ÐµÑÐ¸ÐºÐ¸, Ð±Ð¸Ð¾ÑÐ¸Ð·Ð¸ÐºÐ¸ Ð¸ Ð±Ð¸Ð¾ÑÐ¸Ð¼Ð¸Ð¸.
description: The monograph provides the results of the long-term collaborative research conducted by the scientists of Peter the Great St. Petersburg Polytechnic University (SPbPU), St. Petersburg Institute of Bioregulation and Gerontology, and I. P. Pavlov Institute of Physiology of the Russian Academy of Sciences (RAS). A new group of biologically active (neuroprotective) peptides and their effectiveness when used in various experimental models is presented. The authors studied molecular mechanisms of peptide action. It is the first time when the possibility of interaction of short peptides with DNA, histones, and nucleosomes has been studied in silico. Neuroprotective tripeptides prevent the loss of synaptic contacts in models of neurodegenerative diseases. The monograph presents the results of studies on the effectiveness of short peptides in restoring the morphofunctional state of neural networks in Alzheimer's disease models in vivo. The monograph is intended for specialists in medicine, molecular biology, genetics, biophysics, and biochemistry.