cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Linear functions and duality on the infinite polytorus
Creators: name: Brevig, Ole Fredrik
Publisher: name: arXiv
Year: 2018
Subjects: subject: Functional Analysis (math.FA)
subject: Complex Variables (math.CV)
subject: FOS: Mathematics

description: We consider the following question: Are there exponents $22$. Our approach is based on duality arguments and a detailed study of linear functions. Some related results are also presented.
description: This paper has been accepted for publication in Collectanea Mathematica
title: ADCO, Grènetier de Cîteaux : comptes (1497-1504) (11 H 1172), f. 00469
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: comptes
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172), f. 00469, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Statistical Trends in the Obliquity Distribution of Exoplanet Systems
Creators: name: Muñoz, Diego J.
name: Perets, Hagai B.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Important clues on the formation and evolution of planetary systems can be inferred from the stellar obliquity $ψ$. We study the distribution of obliquities using the California-Kepler Survey and the TEPCat Catalog of Rossiter-MacLaughlin (RM) measurements, from which we extract, respectively, 275 and 118 targets. We infer a "best fit" obliquity distribution in $ψ$ with a single parameter $κ$. Large values of $κ$ imply that $ψ$ is distributed narrowly around zero, while small values imply approximate isotropy. Our findings are: (1) The distribution of $ψ$ in Kepler systems is narrower than found by previous studies and consistent with $κ\sim15$ (mean $\langleψ\rangle\sim19^\circ$ and spread $ψ\sim10^\circ$). (2) The value of $κ$ in Kepler systems does not depend, at a statistically significant level, on planet multiplicity, stellar multiplicity or stellar age; on the other hand, metal-rich hosts, small planet hosts and long-period planet hosts tend to be more oblique than the general sample (at a $\sim$2.5-$σ$ significance level). (3) Hot Jupiter (HJ) systems with RM measurements are consistent with $κ\sim2$, more broadly distributed than the general Kepler population. (4) A separation of the RM sample into cooler ($T_{\rm eff}\lesssim$6250 K) and hotter ($T_{\rm eff}\gtrsim$6250 K) HJ hosts results in two distinct distributions, $κ_{\rm cooler}\sim4$ and $κ_{\rm hotter}\sim1$ (4-$σ$ significance), both more oblique than the Kepler sample. We hypothesize that the total mass in planets may be behind the increasing obliquity with metallicity and planet radius, and that the period dependence could be due to primordial disk alignment rather than realignment of stellar spin.
description: 16 pages, 11 figures, accepted to AJ
Nanomaterials for pregnancy detection
Creators: name: Albilal, Nawal
Publisher: name: Imperial College London
Year: 2014

description: Point of care (POC) is a powerful tool as a diagnostic test because of its advantage of being small, portable device and rapid results obtained. One major class of POC is the lateral flow assay (LFA), which is widely used for protein determinations. A home pregnancy test is the most successful example of the LFAs. A limitation of being quantitative or at best semi quantitative assay leads to improve the assay performance and to enhance its sensitivity. Hence, for this project, a switch from visual detections to electrochemical measurements is the primary goal, which occurred by developing the assay’ concept with keeping the ease and robustness of the traditional LF assay. The integration of streptavidin lateral flow with electrochemical measurements (in particular voltammetric techniques) is the key element to introduce an electrochemical lateral flow assay (ELFA). This concept was based on the amplification of the polymer nanoparticles. A pH responsive eudragit S- 100 was synthesized by nanoprecipitation process. These PNPs are encapsulated with redox active probe such as hydroxylmethyl ferrocene. Eudragit S-100 is dissolved at pH > 7 and it is insoluble in an acidic condition. This dissolution mechanism is preferable since the release of entrapped probe can be controlled until it is being detectable at the test line. Our findings summarized as follows; nanoprecipitation process is able to synthesis PNPs encapsulated both hydroxylmethyl ferrocene and methylene blue. These small-sized particles (~200 nm and ~300 nm) have a highly value negative zeta potentials (-34 mV and -29 mV). These two proprieties respectively, are important in enhancing the probe loading efficiency and in efficient adsorption with the antibody. From our data, it was found that more than 50% of the probes were encapsulated. Further characterizations were performed to investigate the probes’ electroactivity as well as their electrochemical behavior. These voltammetric techniques include cyclic voltammetry and square wave voltammetry, the results suggested good electrochemical behaviors of both probes in respect of their release form the PNPs in immobilized format as well as in the aqueous phase. Importantly, an electrochemical lateral flow assay (ELFA) was investigated the FcMeOH-PNPs and was successfully demonstrated in the presence of varied concentrations of hCG compared to the control (absence of hCG). This indicates that the applied approach was proven. However, further improvements are needed. This led to move toward the screen-printed technology to realize a point of care device.
Optimised protocols for time-critical applications and internetworking in wehicular ad-hoc networks
Creators: name: Rossi, Giorgia
Publisher: name: Imperial College London
Year: 2017

description: Vehicular ad-hoc networks (VANETs) that enable communication among vehicles and between vehicles and unmanned aerial vehicles (UAVs) and cellular base stations have recently attracted significant interest from the research community, due to the wide range of practical applications they can facilitate (e.g., road safety, traffic management and rescue missions). Despite this increased research activity, the high vehicle mobility in a VANET raises concerns regarding the robustness and adaptiveness of such networks to support time-critical applications and internetworking. In this thesis, as a first step toward the design of efficient MAC protocol to support time-critical applications and internetworking, we show that it is indeed possible to follow the dynamics of a network and consequently adapt the transmission probability of the Aloha protocol to reduce the interference and maximise the single-hop throughput between adjacent nodes. Extensive simulation validates the proposed analytical model, which thus can serve as a promising tool to improve VANETs performance. By exploiting the parallel between the CSMA/CA and Aloha performance models, the optimal transmission probability for the Aloha protocol as a function of estimated vehicular density is derived. This probability is then used to obtain the optimal maximum CW that can be integrated in an amended CSMA/CA protocol to maximise the single-hop throughput among adjacent vehicles. We show by means of simulation that the beneficial impact the proposed protocol is increased channel throughput and reduced transmission delay when compared with the standardised protocol CSMA/CA in IEEE 802.11p. These results reveal the applicability of the new, optimised protocol to safety applications and clustering techniques with stringent performance requirements. Lastly, we propose a Stable Clustering Algorithm for vehicular ad-hoc networks (SCalE) internetworking. The exchange of the necessary status information to support the efficient clusters formation can firmly relay on the support of our optimised CSMA/CA protocol. The SCalE algorithm makes use of the knowledge of the vehicles behaviour (explained in Chapter 5) for efficient selection of CHs, and selects a backup CH on top of the CH to maintain the stability of cluster structures. The increased stability and improved performance of the SCalE algorithm is studied and compared with existing clustering algorithms.
Three-integral oblate galaxy models
Creators: name: Robijn, F. H. A.
name: de Zeeuw, P. T.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: A simple numerical scheme is presented for the construction of three-integral phase-space distribution functions for oblate galaxy models with a gravitational potential of Stäckel form, and an arbitrary axisymmetric luminous density distribution. The intrinsic velocity moments can be obtained simultaneously with little extra effort. The distribution of the inner and outer turning points of the short-axis tube orbits that are populated can be specified freely, and is chosen in advance. The entire distribution function is then derived from the density by an iterative scheme that starts from the explicitly known distribution function of the thin-orbit (maximum streaming) model, in which only the tubes with equal inner and outer turning points are populated. The versatility and limitations of this scheme are illustrated by the construction of a number of self-consistent three-integral flattened isochrone models of Kuzmin--Kutuzov type, and by investigation of special cases where the scheme is tractable analytically. This includes the behaviour of the distribution functions in the outer regions of the models. The scheme converges rapidly for models containing orbits with ratios of the outer to inner turning point as large as ten, and is particularly suited for the construction of tangentially anisotropic flattened models, self-consistent as well as non-consistent. The algorithm simplifies in the disk and spherical limit, and can be generalized to triaxial models.
description: uuencoded gziped PostScript, 21 pages without figures. PostScript with figures available from http://www.strw.leidenuniv.nl/dynamics/Papers/ or ftp://ftp.strw.leidenuniv.nl/pub/dynamics/Papers/RobijnDeZeeuw95.tar.Z Accepted by MNRAS
Assessment of the atmospheric fate and environmental impact of amine emissions from post combustion CO2 capture
Creators: name: Manzoor, Saba
Publisher: name: Imperial College London
Year: 2015

description: Emissions from post combustion CO2 capture plants using amine solvents are of concern due to their adverse impacts on the human health and environment. Potent carcinogens such as nitrosamines and nitramines resulting from the degradation of the amine emissions in the atmosphere have not been fully investigated. It is, therefore, imperative to determine the atmospheric fate of these amine emissions, such as their chemical transformation, deposition and transport pathways away from the emitting facility to perform essential human health and environmental risk assessments. In this study an in-depth analysis of the complex atmospheric chemistry mechanisms of monoethanolamine, methylamine and dimethylamine are considered. Rate constants describing the atmospheric chemistry reactions of the amines are obtained within experimental accuracy using theoretical quantum chemistry methods and kinetic modelling. Their dispersion away from the emitting PCCC facility in the atmosphere is quantified using an atmospheric dispersion model, ADMS 5. The cancer incident probability for humans living in vicinity of the plant is also predicted. The implementation of the developed methodology is illustrated by conducting worst-case scenarios on three emitting facilities at different geographical locations. In conclusion, the established method is independent from experimental parameters which can assess the fate of any generic amine emission and its environmental impact regardless of the size and geographical location of the CO2 capture facility. Since PCCC technology is yet to be widely implemented at a commercial scale in operation; the developed method can ensure if a proposed facility complies with the air quality regulatory limits, essential for its chemical discharge permit. The technique can be used to propose ideal plant parameters with respect to its design and recommend ideal geographical locations for industrial installations such that the CO2 capture advantage of using amines can outweigh the risk associated with solvent discharge issues.
Investigating the dietary intake and metabolic disease in South Asian and Caucasian populations
Creators: name: Foroughifar, Neda
Publisher: name: Imperial College London
Year: 2017

description: There is a high prevalence of T2DM and CHD in South Asians who have migrated to developed countries including UK, compared to their Caucasian counterparts. Studies investigating genetics, obesity, and physical activity have not been able to explain the prevalence of metabolic disorders in South Asians. Dietary intake might play a role in the development of metabolic diseases suggested by published work showing contradictory result. We hypothesized that detailed dietary assessment will lead to understanding the high prevalence of metabolic disorders in South Asians. The data of a sub-cohort from LOLIPOP was used to re-examine the dietary intake and metabolic disorders in groups without and with CHD in South Asians versus Caucasians. Initially the estimated dietary records were analysed which revealed higher carbohydrate but lower SFA and alcohol intakes in both South Asian groups, a dietary profile which is not associated with metabolic disorders. It is possible that food components which are not shown in traditional dietary assessment play a role in metabolic diseases. Thus, I undertook metabolomics profiling method for serum and duplicate diet samples with the intention to get further insight in the relationship between dietary intake and metabolic disorders. ¹HNMR technique was applied for both samples. The analysis for serum and food samples showed no difference between South Asians and Caucasians in the UK. But the comparison between South Asians in the UK versus India revealed higher levels of valine, citrate, and glucose but, lower dimethylglycine and phenylalanine. Food analysis revealed higher levels of citrate, glucose, alanine, and glycerol whereas, fumarate and phenylalanine were lower in South Asians in UK. Most of the identified compounds play a role in energy metabolism which raises the possibility of the effect of diet composition on metabolic disorders. Further investigation is required applying a targeted metabolomics study to identify specific pathways.
Proton and electron transfers to dinitrogen on iron phosphine complexes
Creators: name: Crawford, Andrew Dixie
Publisher: name: Imperial College London
Year: 2017

description: The conversion of atmospheric dinitrogen to ammonia is the starting point for the formation of all nitrogen-containing compounds on earth, and is consequently a hugely important chemical transformation. The anthropogenic production of ammonia currently requires enormous amounts of energy, and reducing this energy cost is acknowledged to be a major challenge to research chemistry. Efforts over the last 60 years to realise this goal have taken inspiration from the existing anthropogenic and biological systems capable of performing the fixation of dinitrogen to ammonia, both of which require transition metal catalysts. Synthetic transition metal complexes are capable of catalysing homogeneous dinitrogen fixation increasingly effectively, and iron complexes have moved to the forefront of research in this area. This dissertation explores a broad range of factors relevant to dinitrogen fixation at simple iron phosphine complexes, which have recently been shown to mediate this important transformation extremely efficiently. Chapter 1 introduces the broader context in which these investigations were performed, and outlines current areas of investigation in the field. Chapter 2 then details the preparation of a novel iron bisphosphine framework, and its application to homogeneous dinitrogen fixation. In Chapter 3, alternative iron phosphine complexes with tripodal ligand architectures are discussed, and the results of investigations into the functionalisation of coordinated dinitrogen with protons and other electrophiles are reported. Chapter 4 then describes the possible use of dihydrogen as a source of protons and electrons in homogeneous dinitrogen fixation, and the preparation of unusual tripodal hydride and dihydrogen complexes in this context. Chapter 5 provides the experimental details for all of the investigations performed. Additional materials, including crystallographic data, are given in the Appendix.
Assessment and retrofitting of reinforced concrete buildings with shear walls subject to earthquake loading
Creators: name: Masjuki, Siti Aliyyah
Publisher: name: Imperial College London
Year: 2017

description: A large number of reinforced concrete (RC) buildings not designed to resist seismic loading are located in earthquake prone regions. If these structures are not assessed and eventually strengthened, in the near future they will potentially suffer significant damage due to the effects of earthquakes causing casualties and economic disruption. Thus at present, seismic assessment and retrofitting of existing RC buildings is a major challenge which requires the use of realistic structural analysis techniques and practical and effective strengthening solutions. In this research, the use of RC walls as a global strengthening measure to enhance to seismic performance of existing framed buildings is considered. The study commences with a critical appraisal of existing modelling strategies for RC walls subjected to in-plane loading. The wide-column approach, the use of 2D detailed FE descriptions and macro-elements with nonlinear springs and rigid links are considered, and models based upon these alternative strategies are implemented in ADAPTIC, an advanced finite element code for nonlinear analysis of structures under extreme loading. A parametric study allowed identifying the most effective modelling strategy to be used within detailed nonlinear representations for RC buildings subjected to earthquake loading, and potential enhancements for existing models to be implemented to achieve a better representation of the response of RC walls subjected to in-plane loading. In the second part of the research an enhanced description using macro-elements to describe RC wall units is developed. It employs novel coupled nonlinear springs to describe wall portions modelled as RC panels subjected to biaxial stress/strain states. Model accuracy and efficiency is shown in numerical examples on slender and short walls. In the final part of the research, an advanced 3D modelling strategy for representing the nonlinear dynamic response of RC buildings with shear walls is presented and used in accurate simulations. The seismic assessment of a realistic RC building is carried out and the effectiveness of using RC walls as global strengthening measure is shown comparing the seismic performance of the original structure against that of the retrofitted building.
Rapid prototyping of soft lithography masters for microfluidic devices using dry film photoresist in a non-cleanroom setting
Creators: name: Mukherjee, P
name: Nebuloni, F
name: Gao, H
name: Zhou, Jian
name: Papautsky, Ian
Publisher: name: University of Illinois at Chicago
Year: 2021
Subjects: Uncategorized

description: Fabrication of microfluidic devices by soft lithography is by far the most popular approach due to simplicity and low cost. In this approach PDMS (polydimethylsiloxane) is cast on a photoresist master to generate replicas that are then sealed against glass slides using oxygen plasma. In this work, we demonstrated fabrication of soft photolithography masters using lamination of ADEX dry film as an alternative to the now classic SU-8 resist masters formed by spin coating. Advantages of using ADEX dry film include the easily-achievable uniform thickness without edge bead; simplicity of the process with significant time savings due to non-sticky nature of the film; and fewer health concerns due to less toxic developing solution and antimony-free composition. As we demonstrate, the process can be performed in a low-cost improvised fabrication room in ambient light, in place of a conventional yellow-light cleanroom environment. We believe this approach holds the promise of delivering state-of-the-art microfluidic techniques to the broad field of biomedical and pharmaceutical research.
Aspects of market completion and stochastic volatility
Creators: name: Trabalzini, Romano
Publisher: name: Imperial College London
Year: 2016

description: This work sets out to give a rigorous formulation to market completion as an attempt to investigate the “dynamics of the volatility surface". The center stage in the model is occupied by a latent factor process whose natural filtration is the market filtration and whose cardinality is the multiplicity of the spanning set. Given a strong solution of the purely diffusive SDE instantiating the state, market completeness is predicated on martingale representation: a weights process is identified which replicates any contingent claim(s) observed in the market by a combination of the forward process and a set of options. A rich but tractable class of factor processes whose stochastic variance is a functional of the Wishart family has been singled out. The search for two properties has driven its choice: (i) affinity of the characteristic function and (ii) an adequate geometry of the state space. The decisive factor for (i) has been the availability of a well-understood theory that reduces Backward equations to simple ODEs plus the availability of fast algorithms. The idea behind (ii) has been to pick one that by construction could allow for richer factor cross-correlation. Imposing some additional structure on the functions characterizing the factor process and the boundaries, the check that a particular choice of spanning securities does indeed complete the market has been reformulated as a simple computable condition given in terms of the solution set of the Riccati equation characterizing the solution of the factor process. After some numerics, whereby the robustness of the model is investigated against real market data, the dynamic hedging problem under scrutiny has finally been rephrased into a non-linear tracking problem whereby the discrete-time market prices are interpreted as the small noise observation process whose non-linear relationship with the signal - the state vector- is taken care of by a variation on the Extended Kalman Filter.
Limits on Dust and Metallicity Evolution of Lya Forest Clouds from COBE
Creators: name: Ferrara, A.
name: Nath, B.
name: Sethi, S.
name: Shchekinov, Yu.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We consider possible observational consequences of dust and metals in \lya forest clouds. We relate the dust content, $Ω_d^{Lya}$, to the metal evolution of the absorbers and assume that dust is heated by the ultraviolet background radiation and by the CMB. We find that the dust temperature deviates from $T_{CMB}$ by at most 10% at redshift $z=0$. The \lya cloud dust opacity to redshift $\sim 5$ sources around the observed wavelength $λ_0 \sim 1 μ$m is $\sim 0.13$, and could affect observations of the distant universe in that band. The expected CMB spectral distortions due to high-$z$ dust in \lya clouds is $\sim 1.25-10$ smaller than the current COBE upper limit, depending on the metallicity evolution of the clouds. If \lya clouds are clustered, the corresponding CMB anisotropy due to dust is $\sim 10^{-1}$ on angular scales $θ\simlt 10''$ at frequencies probed by various future/ongoing FIR missions, which makes these fluctuations potentially detectable in the near future. Emission from CII fine-structure transitions could considerably contribute to submm range of the FIR background radiation. Depending on the ionization of carbon and on the density of metal enriched regions, this contribution can be comparable with the observed residual flux at $λ\approx 0.15$ mm, after CMB subtraction. We argue that constraints on metal evolution versus redshift can be obtained from the observed flux in that range.
description: 8 pages, 3 figures, MNRAS, in press
A Lower Limit on the Age of the Universe
Creators: name: Chaboyer, Brian
name: Kernan, Peter J.
name: Krauss, Lawrence M.
name: Demarque, Pierre
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We report the results of a detailed numerical study designed to estimate both the absolute age and the uncertainty in age (with confidence limits) of the oldest globular clusters. Such an estimate is essential if a comparison with the Hubble age of the universe is to be made to determine the consistency, or lack thereof, of various cosmological models. Utilizing estimates of the uncertainty range (and distribution) in the input parameters of stellar evolution codes we produced 1000 Monte Carlo realizations of stellar isochrones, with which we could fit the ages of the 18 oldest globular clusters. Incorporating the observational uncertainties in the measured color-magnitude diagrams for these systems and the predicted isochrones, we derived a probability distribution for the mean age of these systems. The one-sided 95$\%$ C.L.~ lower bound for this distribution occurs at an age of 12.07 Gyr. This puts interesting constraints on cosmology which we discuss. Further details, including a description of the distributions, covariance matrices, dependence upon individual input parameters, etc.\ will appear in a future article.
description: Latex, 18 pages, plus 2 postscript figures (one color) available as separate uuencoded file
AdS$_2$ Holography: Mind the Cap
Creators: name: Bena, Iosif
name: Heidmann, Pierre
name: Turton, David
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: AdS$_2$ plays an extremely important role in black-hole physics. We construct several infinite families of supergravity solutions that are asymptotically AdS$_2$ in the UV, and terminate in the IR with a cap that is singular in two dimensions but smooth in ten dimensions. These solutions break conformal invariance, and should correspond to supersymmetric ground states of a holographically dual CFT$_1$. We solve the free massless scalar wave equation on a family of these solutions, finding towers of finite-energy normalizable bound-state excitations. We discuss the intriguing possibility that these excitations correspond to time-dependent excitations of the dual CFT$_1$, which would imply that this CFT$_1$ is dynamical rather than topological, and hence cannot have a conformally invariant ground state.
description: 50 pages, 5 figures, v2: typos corrected, reference added
CBS News Poll: November 2018
Creators: name: CBS News
Publisher: name: Roper Center for Public Opinion Research
Year: 2021

description: President Donald Trump job approval (4); right direction/wrong track (1); favorability of political parties (2); economy (2); November 2018 congressional elections (3); political parties care about people like you (2); women in Congress (4); Speaker of the House of Representatives (1); Democrats in Congress (4); wall along United States-Mexico border (4); investigation into Russian interference in the 2016 presidential election (2); changes to health care laws in United States (1); United States election and voting systems (5); holiday shopping (3); discussing politics at Thanksgiving dinner (1); registered to vote (1); voted in previous elections (2).
Regulation of inflammation by platelets in tuberculosis
Creators: name: Fox, Katharine
Publisher: name: Imperial College London
Year: 2017

description: Introduction: Mycobacterium tuberculosis (M.tb) infection, causing tuberculosis (TB), kills more people than any other pathogen in the world. Innate immune cells are stimulated by M.tb antigens to result in an inflammatory and tissue-degrading phenotype associated with TB transmission, morbidity and mortality. Platelets are known to interact with the innate immune system and regulate matrix metalloproteinase (MMP)-driven tissue destruction but their role in the pathology of TB is not understood. My hypothesis is that platelets drive TB immunopathology through mechanisms that regulate key innate immune cell responses to M.tb infection. Methods: Multiplex analysis of bronchoalveolar lavage (BALF) and immunohistochemistry of a pulmonary TB mouse model detected platelets in the M.tb-infected lung. I developed a novel in vitro TB model using freshly isolated and thrombin-activated platelets in co-culture with primary human monocytes, neutrophils and airway epithelial cells. I assessed MMP and cytokine regulation at the gene, protein and functional level, with quantitative RT-PCR, Luminex bead array, ELISA, DQ matrix degradation, western blot and bacterial colony counts. Results: Investigation in the M.tb-infected lung revealed abundant platelets in a murine TB model, and activated platelet-derived factors in human BALF. Platelets upregulated specific MMPs, cytokines and chemokines in M.tb-infected monocytes, leading to type I collagen destruction and reduced intracellular bacterial killing. The platelet-secreted product CD40 ligand (CD40L) upregulated MMP-1 secretion, however, direct platelet-monocyte contact enhanced MMP regulation further. Platelets regulated monocytes through phosphorylated phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K), extracellular signal-regulated kinase (ERK)-1/2 and p38 pathways. Interestingly, platelets inhibited early neutrophil MMP secretion in TB. Platelet-secreted factors upregulated airway epithelial cell collagenase and gelatinase activity alone and in combination with TB networks. Conclusions: My data show that platelets are present at the site of pulmonary M.tb infection. Platelets regulate inflammation and tissue destruction driven by different leukocytes and respiratory epithelial cells through multiple signalling pathways.
Mapping inertial migration in the cross section of a microfluidic channel with high-speed imaging
Creators: name: Zhou, Jian
name: Peng, Z
name: Papautsky, Ian
Publisher: name: University of Illinois at Chicago
Year: 2021
Subjects: Uncategorized

description: The wide adoption of inertial microfluidics in biomedical research and clinical settings, such as rare cell isolation, has prompted the inquiry of its underlying mechanism. Although tremendous improvement has been made, the mechanism of inertial migration remains to be further elucidated. Contradicting observations are not fully reconciled by the existing theory, and details of the inertial migration within channel cross sections are missing in the literature. In this work, for the first time, we mapped the inertial migration pathways within channel cross section using high-speed imaging at the single-particle level. This is in contrast to the conventional method of particle streak velocimetry (PSV), which provides collective information. We also applied smoothed particle hydrodynamics (SPH) to simulate the transient motion of particles in 3D and obtained cross-sectional migration trajectories that are in agreement with the high-speed imaging results. We found two opposing pathways that explain the contradicting observations in rectangular microchannels, and the force analysis of these pathways revealed two metastable positions near the short walls that can transition into stable positions depending on the flow condition and particle size. These new findings significantly improve our understanding of the inertial migration physics, and enhance our ability to precisely control particle and cell behaviors within microchannels for a broad range of applications.
D-9.2-INITIAL COMMUNICATION PLAN
Creators: name: Ziemba, Alexander
Publisher: name: Zenodo
Year: 2021
Subjects: Communication Plan

description: This document outlines the initial communication flow pathways for the project, bother internal and external, which is of great importance for a well working consortium and good communication to externals. The UNITED project requires open channels of communication with many different parties, between the large number of partners, specific to the communities surrounding and involved with the demonstration pilots, and external entities that are concerned  with the development, deployment, and management of multi-use from the local to international scales.
Measuring Earth Tables
Creators: name: Tubiello, Francesco Nicola
Publisher: name: Zenodo
Year: 2024

description: This dataset contains two Tables appearing in the manuscript ''Measuring Earth for Policy Action'' by Tubiello, Carlson, Mari --submitted to Science on Feb 19 2024.

Table 1. Dataset of measure values of earth quantities provided by the IPCC AR6 and collected by the authors among all ''very likely'' outcomes summarised by the IPCC AR6 SPMs across WGI, WGII and WGIII.

Information provided includes mean estimates, boundaries of 90% CI, relative uncertainty as the inverse of accuracy. Additional information specifies WG, place in SPM where data appear (i.e., para., Fig. or Tab.), plus a note detailing nature of the data being collected.

Table 2. Aggregated data from Tab.1 in terms of observed, estimated and simulated/projected data.
The Need for Meaning: Understanding the Dimensions of the "Meanings of Life!" - Insights from ‘Great Thinkers’ including Jung, Frankl,  Geertz,  Baumeister, Dr. Paul Wong, Steger,  Reker, Plus the Synthesis-Consensus of Frankl, Jung, & James - with preamb
Creators: name: Peck Jr, Charles
Publisher: name: Humanities Commons
Year: 2008
Subjects: subject: Meaning (Psychology)
subject: Meaning (Philosophy)
subject: Truth
subject: Logotherapy
subject: Jungian psychology
subject: Existential psychology
subject: Psychology
subject: FOS: Psychology
subject: Manners and customs
subject: Culture

description: The Meaning of Meaning As a metaphor, which might give a better perspective of meaning, could possibly be compared to the role and purpose of blood in physiology and the human body. Meaning, like blood is essential to life. We live and breathe meaning. That's what our world is made of-meaning. Similar to how blood circulates through our body and delivers essential substances like oxygen and nutrients to the body's cells, meanings, symbols, circulate among our worldviews, ideologies, and beliefs-which are all intricately interconnected by these meanings, symbols and their intrinsic goals and purposes. Blood also transports metabolic waste products away from cells, and similarly, "meaning reconstruction," which involves at times, discarding false truths and outdated or useless meanings-is often found for instance in the painful grieving processes. Meaning, which includes, goal-setting, orientation, awareness, as well as purpose and guidance is the life blood of human consciousness and human understanding.   Many of Psychology's 'Great Thinkers', such as Carl Jung, Viktor Frankl, Clifford Geertz, Roy Baumeister, Paul Wong, as well as most existential and positive psychologists, advocate that a powerful Need for Meaning is vital and pivotal in human consciousness and humanity. The central concept of all these icons is the concept of the human being primarily as a meaning-seeking animal. Viktor Frankl, a Jewish survivor of Nazi concentration camps and a pioneer of psychoanalysis and psychology, based his theory on the principle that human beings possess a very powerful Will to Meaning: "Man's search for meaning is the primary motivation in his life and not a 'secondary rationalization of instinctual drives. This meaning is unique and specific in that it must and can be fulfilled by him alone; only then does it achieve a significance which will satisfy his own will to meaning." (p.99 search)
Picae Linnaeus, 1758, ord. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Picae

description: Picae [ord. nov.]
II. PICAE.
Rostrum subcompressum, convexum.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 96, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
DIVERSE AND LINKED: FARMERS' ORGANISATIONS IN TANZANIA
Creators: name: Mattee, Amon
name: Lassalle, Thierry
name: Mattee, Amon
name: Lassalle, Thierry
Publisher: name: Unknown
Year: 1994
Subjects: Agribusiness

description: Experiences from research and extension projects being run at Sokoine University of Agriculture (SUA) and elsewhere in Tanzania, indicate that farmers' groups can play an instrumental role in the generation of appropriate solutions to small farmers' problems. An approach which uses farmers! groups as points of entry in the rural development process must take into account the diversity of these groups, their inter-linkages or networking, their independence and their relationships with professionals. Both farmers and professionals have to be willing to devote time to know and work with each other. This approach poses two challenges: for professionals to accept (and promote) the increasing emancipation of farmers, and for all concerned to challenge pre-conceived notions of the valuation of time and of the process of development.
CLIENT-DRIVEN CHANGE AND INSTITUTIONAL REFORM IN AGRICULTURAL EXTENSION: AN ACTION LEARNING EXPERIENCE FROM ZIMBABWE
Creators: name: Hagmann, Jurgen
name: Chuma, Edward
name: Connolly, Mike
name: Murwira, Kudakwashe
name: Hagmann, Jurgen
name: Chuma, Edward
name: Connolly, Mike
name: Murwira, Kudakwashe
Publisher: name: Unknown
Year: 1998
Subjects: Institutional and Behavioral Economics

description: This paper describes the development and the institutionalisation of a participatory approach to innovation development and extension which took place through an action learning process in Zimbabwe. In order to scale up this approach through institutionalisation within the agricultural extension department it was necessary to adopt a complex and multi-faceted strategy. The development of 'learning cases', the exposure of extension officers to these cases, as well as deliberate trespassing and provoking action were means used to raise awareness and commitment for change. An informal network ofprojects which were all pursuing participatory development acted as a lobby group to strengthen the influence of the approach and bring it into mainstream thinking. Once commitment for change had developed in the extension department, operationalisation of participatory extension approaches became a major challenge. This reform required substantial changes in the organisational culture, roles, relationships and attitudes of individuals and groups. Changes of that nature are presently being addressed in an organisational development programme within the extension department, which includes a learning process to facilitate behavioural and attitudinal changes. The paper concludes that the institutionalisation and operationalisation of participatory approaches takes far more than simply the training of staff in participatory methods. These are complex interventions which require considerable commitment from all actors, sound strategies, flexible methodologies, a conducive atmosphere for learning and a focus on human relationships rather than technical and formal issues.
Preventing tuberculosis in people at high risk
Creators: name: Wingfield, Tom
Publisher: name: Imperial College London
Year: 2015

description: Background Poverty drives TB rates but the current TB control approach is disproportionately biomedical. In 2015, the World Health Organisation’s End TB Strategy explicitly identified the need to address the social determinants of TB through socioeconomic interventions. However, evidence concerning poverty-reduction and costs-mitigation strategies is limited. My PhD research aimed to address this knowledge gap. Methods During this PhD, I aimed to develop as an independent researcher while addressing the social determinants of TB in impoverished shantytown communities of Callao, Peru, through integrated projects. The research was divided into two phases: 1) Final follow-up, data collection, analysis, and write-up of: a case-control study defining the TB-poverty association; an ecological study assessing poverty-related risk factors for TB infection and disease; and a cohort study identifying TB-related costs of TB-affected families and creating a clinically-relevant catastrophic costs threshold. 2) Conception, design, implementation, data collection, analysis, and write-up of a household-randomized controlled study of a socioeconomic intervention to improve TB cure and prevention. Results The first phase showed that TB remains a disease of people living in poverty, that “free” TB care was expensive for impoverished TB-affected families to afford, and that incurring catastrophic costs explained as many adverse outcomes as multi-drug resistant (MDR) TB. The second phase showed that, in households receiving the TB-specific socioeconomic intervention, TB-affected households were less likely to incur catastrophic costs, household contacts were more likely to start and adhere to TB preventive therapy, and TB patients were more likely to be cured. Conclusion In impoverished Peruvian shantytowns, poverty remains associated with TB and incurring catastrophic TB-related costs predicted adverse TB outcome. A novel TB-specific socioeconomic intervention reduced catastrophic costs and improved TB preventive therapy uptake and TB cure. The impact of the intervention on TB control will now be evaluated during the Community Randomized Evaluation of a Socioeconomic Intervention to Prevent TB (CRESIPT) study.
Psittacus Linnaeus, 1758, gen. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Psittaciformes
Psittacidae
Psittacus

description: Psittacus [gen. nov.]
Rostrum aduncum: mandibula superiore mobili cera instructa.
Lingua carnosa, obtusa, integra.
Pedum digiti antici 2, posticique 2.
* Macrouri cauda cuneiformi.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 96, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
User needs over time
Creators: name: Silberer, Jan
name: Astfalk, Stefanie
name: Planing, Patrick
name: Müller, Patrick
name: :Unav
Publisher: name: Fraunhofer-Gesellschaft
Year: 2022
Subjects: Acceptability
Acceptance
Adoption
Technology

description: This paper conceptualizes how consumers perceive innovations at different stages of technology maturity. The market and technology maturity model (MTMM) combines the constructs of acceptability, acceptance, and adoption with the widely used technology readiness level (TRL). The MTMM proposes that different aspects impact users’ attitudes and behavior at different stages of technology maturity. To demonstrate the effect of technology maturity on the acceptance factors, a review was conducted based on previous studies on the acceptance of new technologies at various stages of technological maturity. The findings demonstrate that performance expectancy remains stable across the TRL stages, but effort expectancy tends to gain importance only after TRL 7. This indicates that consumers do not consider effort when the technology is still in early development. The results show that the importance of technology acceptance constructs differs across the stages of technology maturity. A limitation of this study is that only the most commonly used factors influencing acceptance have been considered. Future meta-studies should confirm the hypothesis with other factors such as social influence and hedonic motivation.
Exploring novel applications for ursodeoxycholic acid in the treatment of cardiovascular conditions
Creators: name: Adeyemi, Oladipupo
Publisher: name: Imperial College London
Year: 2016

description: As a bile acid, ursodeoxycholic acid (UDCA) is found endogenously formed in humans and other mammals where it is primarily involved in lipid metabolism. It is approved under a number of different brand names for the treatment of gallstones and Primary Billiary Cholangitis (PBC). Previous studies in cardiac cell models of Intrahepatic Cholestasis of Pregnancy (ICP) have demonstrated that UDCA can also be protective against the conduction slowing effects of the bile acid, taurocholic acid (TC). Therefore, this thesis aimed to identify novel applications for UDCA in the treatment of fetal arrhythmiasin ICP. It describes the development of a novel isolated-perfused neonatal rat heart model as a model of the fetal heart (FH) and an adult female rat heart model as a model of the maternal heart (MH) for evaluating the mechanism of bile acid induced arrhythmias. Using optical mapping and electrocardiogram (ECG) recording techniques, it separately evaluated TC effects in the atria and ventricles of the FH and compared them to effects in the MH model. It also evaluated the effects of UDCA in ischemia in a pilot study. It was observed that TC treatment induced significant conduction slowing in both the atria (ECG PR interval prolongation) and ventricles of the FH, but as occurs in ICP, these effects were absent or less pronounced in the MH model. Interestingly, co-administration of UDCA with TC was protective as it inhibited the observed conduction slowing effects. Using selective cardiac calcium channel blockers, it demonstrated that the conduction slowing effects of TC were mediated by blockade of the T-type calcium channel subtype. This was confirmed using the patch clamp technique that demonstrated that TC reduces the calcium current amplitude in neonatal rat and adult human fetal cardiomyocytes and this effect was inhibited with UDCA treatment. No beneficial effects were identified for UDCA in the treatment of acute global ischemia.
A New Method for the Determination of the Hubble Parameter
Creators: name: Bergh, Sidney van den
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: By chance, the slope of the Mv(max) versus (B-V)max relation for recent theoretical models of supernovae of Type Ia (SNe Ia) by Hoflich & Khokhlov is indistinguishable from the slope of a reddening line in the V versus B-V plane. This coincidence allows one to determine a parameter Mv*(max) for SNe Ia that is independent of both supernova detonation model and of interstellar reddening. Calibrating Mv*(max) with observations of SNe Ia by Hamuy et al. yields values of the Hubble parameter Ho in the range 55 - 60 km s-1 Mpc-1 . The discrepancy between this result, and values of Ho recently obtained from observations of Cepheids in the Virgo cluster, suggests that either (1) the Cepheid distance scale is wrong, (2) the SN Ia models of Hoflich & Khokhlov are too bright by ~ 0.75 mag near maximum light, or (3) their models are too red by \~ 0.25 mag in B-V.
description: 12 pages and 1 figure as uuencoded compressed Postscript. Also available at http://www.dao.nrc.ca/DAO/SCIENCE/science.html