cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Mirrors and Visions: Nu Luu Tho Quan and the Woman Question in Interwar Vietnam
Creators: name: Aitchison, Madeleine
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2023
Subjects: Vietnam
History
Southeast Asia
Women

description: This thesis examines the varied output of a small press called Nữ Lưu Thơ Quán (Women’s Bookstore) that operated in Gò Công, Cochinchina from 1928 until 1930. Under the editorial direction of a woman named Phan Thị Bạch Vân (1903-1980), this press sought to influence Vietnamese women’s involvement in their families and communities through novels and biographies, along with instructive and prescriptive literature. Bạch Vân and her cohort of Vietnamese intellectuals derived influence from women’s movements in France, the United States, China, and Japan. They translated a diverse range of ideas and concepts through their own unique lens, with attention paid to their audience and desired influence. I combine literary and historical analyses to consider the significance of works in Nữ Lưu Thơ Quán’s catalogue, such as: Phan Thị Bạch Vân’s novels, Kiếp hoa thảm sử (1928-1929), Nữ anh tài (1928), and Lâm Kiều Loan (1932), the biographies of Madame Roland (1754-1793) and Qiu Jin (1875-1907), and instructive books by Bạch Vân and a writer named Đạm Phương (1881-1947), called Vần Quốc ngữ (1929) and Gia Đình Giáo Dục (1928). This dissertation examines written media that has hitherto been unexplored and shows Vietnamese women’s serious involvement in what contemporaries termed “the Woman’s Question.” Additionally, I show how a director of a small women’s press sought to ensure a remarkable future for the Vietnamese derived from her own vision and through the direction of other women.
Cell type-specific mechanisms coupling protease-activated receptor-1 to infectious colitis pathogenesis
Creators: name: Steinbrecher, K.A.
name: Antoniak, S.
name: Boucher, A.A.
name: Qualls, J.
name: Crowther, R.R.
name: Shafer, J.
name: Palumbo, J.S.
name: Rosenfeldt, L.
name: Flick, M.J.
name: McKell, M.C.
name: Mureb, D.
name: Whitt, J.
name: Alenghat, T.
name: Sharma, B.K.
name: Lane, A.
name: Mackman, N.
Publisher: name: Blackwell Publishing Ltd
Year: 2020

description: Background: Protease-activated receptor-1 (PAR-1) plays a major role in multiple disease processes, including colitis. Understanding the mechanisms coupling PAR-1 to disease pathogenesis is complicated by the fact that PAR-1 is broadly expressed across multiple cell types. Objective: Determine the specific contributions of PAR-1 expressed by macrophages and colonic enterocytes to infectious colitis. Methods: Mice carrying a conditional PAR-1 allele were generated and bred to mice expressing Cre recombinase in a myeloid- (PAR-1ΔM) or enterocyte-specific (PAR-1ΔEPI) fashion. Citrobacter rodentium colitis pathogenesis was analyzed in mice with global PAR-1 deletion (PAR-1−/−) and cell type-specific deletions. Results: Constitutive deletion of PAR-1 had no significant impact on weight loss, crypt hypertrophy, crypt abscess formation, or leukocyte infiltration in Citrobacter colitis. However, colonic shortening was significantly blunted in infected PAR-1−/− mice, and these animals exhibited decreased local levels of IL-1β, IL-22, IL-6, and IL-17A. In contrast, infected PAR-1ΔM mice lost less weight and had fewer crypt abscesses relative to controls. PAR-1ΔM mice had diminished CD3+ T cell infiltration into colonic tissue, but macrophage and CD4+ T cell infiltration were similar to controls. Also contrasting results in global knockouts, PAR-1ΔM mice exhibited lower levels of IL-1β, but not Th17-related cytokines (ie, IL-22, IL-6, IL-17A). Infected PAR-1ΔEPI mice exhibited increased crypt hypertrophy and crypt abscess formation, but local cytokine elaboration was similar to controls. Conclusions: These studies reveal complex, cell type-specific roles for PAR-1 in modulating the immune response to Citrobacter colitis that are not readily apparent in analyses limited to mice with global PAR-1 deficiency.
RICERCHE SULLA DISTRIBUZIONE ED ECOLOGIA DI BATILLIPES PENNAKI MARCUS IN UNA SPIAGGIA PUGLIESE (HETEROTARDIGRADA)
Creators: name: DE ZIO, Susanna
name: GRIMALDI, Piero
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1964

description: A quantitative study of the interstitial fauna of the Cozze, a beach near Bari, has been done, following different periods of the year; the granulometric and mineralogical characteristics of the beach have been laid down. Special attention has been given to the distribution of Batillipes pennaki Marcus (Heterotardigrada) wich represents the most conspicuous stocking, as regards the shore line, the depth, the quantity of interstitial water and the temperature.
The following conclusions can been drawn from a survey of the data : a) Batillipes pennaki follows the oscillations of the shore line, drawing near it during the hottest months and bearing off during coldest ones; b) in the first meters it is specially found near the surface, while towards the interior of the beach,itisfoundat a greater depth in the sand; c) there are daily migrations linked with the evaporation and the increase in temperature, that is why the Batillipes goes deeper in the afternoon; d) ananalysis of the horizontal distribution of the two groups allows to conclude to a possible competition between Tardigrades and Nematodes.
A geometric approach to quantum control in projective Hilbert spaces
Creators: name: Pastorello, Davide
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: A quantum theory in a finite-dimensional Hilbert space can be geometrically formulated as a proper Hamiltonian theory as explained in [2, 3, 7, 8]. From this point of view a quantum system can be described in a classical-like framework where quantum dynamics is represented by a Hamiltonian flow in the phase space given by projective Hilbert space. This paper is devoted to investigate how the notion of accessibility algebra from classical control theory can be applied within geometric Hamiltonian formulation of Quanum Mechanics to study controllability of a quantum system. A new characterization of quantum controllability in terms of Killing vector fields w.r.t. Fubini-Study metric on projective space is also discussed.
description: 11 pages
Coagulation Abnormalities and Thrombosis in Patients Infected with SARS-CoV-2 and Other Pandemic Viruses
Creators: name: Antoniak, S.
name: Key, N.S.
name: MacKman, N.
name: Wolberg, A.S.
name: Kasthuri, R.
Publisher: name: Lippincott Williams and Wilkins
Year: 2020

description: The world is amid a pandemic caused by severe acute respiratory syndrome-coronavirus 2. Severe acute respiratory syndrome-coronavirus causes serious respiratory tract infections that can lead to viral pneumonia, acute respiratory distress syndrome, and death. Some patients with coronavirus disease 2019 (COVID-19) have an activated coagulation system characterized by elevated plasma levels of d-dimer - a biomarker of fibrin degradation. Importantly, high levels of D-dimer on hospital admission are associated with increased risk of mortality. Venous thromboembolism is more common than arterial thromboembolism in hospitalized COVID-19 patients. Pulmonary thrombosis and microvascular thrombosis are observed in autopsy studies, and this may contribute to the severe hypoxia observed in COVID-19 patients. It is likely that multiple systems contribute to thrombosis in COVID-19 patients, such as activation of coagulation, platelet activation, hypofibrinolysis, endothelial cell dysfunction, inflammation, neutrophil extracellular traps, and complement. Targeting these different pathways may reduce thrombosis and improve lung function in COVID-19 patients.
Uniform and virus-free citrus rootstocks production via nucellus culture
Creators: name: Sepehrtaj, A.
name: Shahsavar, A.R.
Publisher: name: Advances in Horticultural Science
Year: 2017

description: Prevalence of various virus and virus-like diseases is among the main reasons for the decrease in quality and quantity of citrus crops. These diseases are mainly spread through the propagation method in citrus which is budding. Using nucellus culture of bitter orange and Mexican lime seeds, uniform and virus-free rootstocks could be produced so that the diseases prevalence could be prevented. In order to generate adventitious shoots from nucellus culture in each of the two rootstocks, direct organogenesis method is used. In all conducted experiments, Murashige and Skoog (MS) medium were used. Two plant growth regulators of benzyl adenine (BA) in 0, 1, 1.5 and 2 mg l-1 concentration and gibberellins (GA) in 0, 1 and 2 mg l-1 concentration were used in the medium and the main effects of each plant growth regulator were studied separately and their interaction on shoot generation were also surveyed. Considering the retrieved data, it was determined that the interaction of BA and GA have a higher impact on shooting, comparing to the cases where each of the regulators is used alone. In Mexican lime rootstock, the best culture medium for generating shoots from nucellus culture is the culture medium containing 2 mg l-1 BA and 2 mg l-1 GA and in bitter orange rootstock, the highest shooting rate was attributed to the culture medium containing 2 mg l-1 GA and 1 mg l-1 BA. For the Mexican lime and bitter orange shoots rooting, indole butyric acid (IBA) was used. The concentrations of this plant growth regulator used in Mexican lime were 0, 0.5, 1 and 1.5 mg l-1 and for bitter orange were 0, 1 and 1.5 mg l-1. The highest rooting rate for Mexican lime was in culture medium containing 0.5 mg l-1 IBA and for bitter orange, it was the culture medium containing 1 mg l-1 IBA. The obtained plantlets were gradually adapted with the external environment.
description: Advances in Horticultural Science, Vol 31 No 3 (2017)
Roles of Coagulation Proteases and PARs (Protease-Activated Receptors) in Mouse Models of Inflammatory Diseases
Creators: name: Owens, A.P.
name: Spronk, H.M.
name: Antoniak, S.
name: Hisada, Y.
name: Posma, J.J.
name: Grover, S.P.
name: Mackman, N.
Publisher: name: Lippincott Williams and Wilkins
Year: 2019

description: Activation of the blood coagulation cascade leads to fibrin deposition and platelet activation that are required for hemostasis. However, aberrant activation of coagulation can lead to thrombosis. Thrombi can cause tissue ischemia, and fibrin degradation products and activated platelets can enhance inflammation. In addition, coagulation proteases activate cells by cleavage of PARs (protease-activated receptors), including PAR1 and PAR2. Direct oral anticoagulants have recently been developed to specifically inhibit the coagulation proteases FXa (factor Xa) and thrombin. Administration of these inhibitors to wild-type mice can be used to determine the roles of FXa and thrombin in different inflammatory diseases. These results can be compared with the phenotypes of mice with deficiencies of either Par1 (F2r) or Par2 (F2rl1). However, inhibition of coagulation proteases will have effects beyond reducing PAR signaling, and a deficiency of PARs will abolish signaling from all proteases that activate these receptors. We will summarize studies that examine the roles of coagulation proteases, particularly FXa and thrombin, and PARs in different mouse models of inflammatory disease. Targeting FXa and thrombin or PARs may reduce inflammatory diseases in humans.
สภาพแวดล้อมในบ้านของผู้สูงอายุที่มีความเสี่ยงต่อการพลัดตกหกล้ม: กรณีศึกษา ตำบลแม่กา อำเภอเมือง จังหวัดพะเยา
Creators: name: พันธพัฒน์ บุญมา
Publisher: name: คณะสถาปัตยกรรมศาสตร์
Year: 2020
Subjects: ความเสี่ยงของผู้สูงอายุ
ลดความเสี่ยงการพลัดตกหกล้ม
อาคารที่พักอาศัย

description: วารสาร สิ่งแวดล้อมสรรค์สร้างวินิจฉัย (Built Environment Inquiry BEI), 19, 3, 43-60
(507) Alexa Ogabril
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A hybrid of 1-deoxynojirimycin and benzotriazole induces preferential inhibition of butyrylcholinesterase (BuChE) over acetylcholinesterase (AChE)
Creators: name: Evangelista, Tereza Cristina Santos
name: López, Óscar
name: Puerta, Adrián
name: Fernandes, Miguel X.
name: Ferreira, Sabrina Baptista
name: Padrón, José M.
name: Fernández-Bolaños, José G.
name: Sydnes, Magne O.
name: Lindbäck, Emil
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: The synthesis of four heterodimers in which the copper(I)-catalysed azide-alkyne cycloaddition was employed to connect a 1-deoxynojirimycin moiety with a benzotriazole scaffold is reported. The heterodimers were investigated as inhibitors against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The heterodimers displayed preferential inhibition (> 9) of BuChE over AChE in the micromolar concentration range (IC50 = 7–50 µM). For the most potent inhibitor of BuChE, Cornish-Bowden plots were used, which demonstrated that it behaves as a mixed inhibitor. Modelling studies of the same inhibitor demonstrated that the benzotriazole and 1-deoxynojirimycin moiety is accommodated in the peripheral anionic site and catalytic anionic site, respectively, of AChE. The binding mode to BuChE was different as the benzotriazole moiety is accommodated in the catalytic anionic site.
Passive scalars: mixing, diffusion and intermittency in helical and non-helical rotating turbulence
Creators: name: Imazio, P. Rodriguez
name: Mininni, P. D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We use direct numerical simulations to compute structure functions, scaling exponents, probability density functions and turbulent transport coefficients of passive scalars in turbulent rotating helical and non-helical flows. We show that helicity affects the inertial range scaling of the velocity and of the passive scalar when rotation is present, with a spectral law consistent with $\sim k_{\perp}^{-1.4}$ for the passive scalar variance spectrum. This scaling law is consistent with the phenomenological argument presented in \cite{imazio2011} for rotating non-helical flows, wich states that if energy follows a $E(k)\sim k^{-n}$ law, then the passive scalar variance follows a law $V(k) \sim k^{-n_θ}$ with $n_θ=(5-n)/2$. With the second order scaling exponent obtained from this law, and using the Kraichnan model, we obtain anomalous scaling exponents for the passive scalar that are in good agreement with the numerical results. Intermittency of the passive scalar is found to be stronger than in the non-helical rotating case, a result that is also confirmed by stronger non-Gaussian tails in the probability density functions of field increments. Finally, Fick's law is used to compute the effective diffusion coefficients in the directions parallel and perpendicular to the rotation axis. Calculations indicate that horizontal diffusion decreases in the presence of helicity in rotating flows, while vertical diffusion increases. We use a mean field argument to explain this behavior in terms of the amplitude of velocity field fluctuations.
title: Εφαρμογή συστημάτων ελέγχου σε τμήματα κίνησης ενός ηλεκτρικού οχήματος
title: Application of control systems at the driving units of an electric car
Creators: name: Τσαραι Ρενατο
Publisher: name: Technical University of Crete
Year: 2020

description:  Η ανάγκη υιοθέτησης βιώσιμων πηγών ενέργειας με σκοπό την προστασία του περιβάλλοντος σε συνδυασμό με τη συνεχή προσπάθεια για αυτοματισμό, έχει ως αποτέλεσμα την ραγδαία εξέλιξη των ηλεκτρικών οχημάτων και των συστημάτων αυτοματισμού στη σύγχρονη αυτοκινητοβιομηχανία. Απώτερος σκοπός της παρούσης διπλωματικής εργασίας είναι η ερευνητική εμβάθυνση στον τομέα της εφαρμογής συμβατικών (κατά κύριο λόγο) συστημάτων ελέγχου σε προκαθορισμένα τμήματα κίνησης ενός ηλεκτρικού οχήματος: στον ηλεκτρικό κινητήρα και τις αναρτήσεις.
                Με βάση τα παραπάνω, η διπλωματική εργασία ξεκινάει με μία ιστορική αναδρομή για την εμφάνιση των πρώτων οχημάτων, έως και την σημερινή εποχή που χαρακτηρίζεται από την ολοένα και αυξανόμενη ανάγκη χρήσης υβριδικών/ηλεκτρικών οχημάτων. Στην συνέχεια, παρουσιάζονται συνοπτικά όλα τα μέρη κίνησης ενός ηλεκτρικού οχήματος με έμφανση να δίδεται στον ηλεκτρικό κινητήρα, τα συστήματα ισχύος, τα είδη των συσσωρευτών, καθώς και τις αναρτήσεις. Έπειτα, παρουσιάζεται συνοπτικά η έννοια και η θεωρία του ελεγκτή PID που αποτελεί (αν και συμβατικό σύστημα ελέγχου) μία από τις βασικές επιλογές της ερευνητικής κοινότητας στην μελέτη κίνησης ενός οχήματος.
                Ως επόμενο βήμα, παρουσιάζεται το βασικό κομμάτι της διπλωματικής εργασίας. Ειδικότερα, παρουσιάζεται το μαθηματικό μοντέλο του εκάστοτε τμήματος κίνησης ενός οχήματος (π.χ. κινητήρας και αναρτήσεις) και αναλύεται μία επιλεγμένη σειρά μελετών της βιβλιογραφίας στον τομέα εφαρμογής συστημάτων ελέγχου. Ειδικότερα, αναλύονται οι σύγχρονες μέθοδοι “tuning” ενός ελεγκτή PID με χρήση αλγορίθμων της Τεχνητής Νοημοσύνης (π.χ. Γενετικοί Αλγόριθμοι, Νευρωνικά δίκτυα) προσφέροντας έτσι στους μηχανικούς νέες μεθόδους αντιμετώπισης τέτοιον προβλημάτων. Επιπλέον γίνεται η σύγκριση και η αξιολόγηση τους με συμβατικές μεθόδους ρύθμισης ελεγκτών PID όπως είναι για παράδειγμα η κλασσική μέθοδος Ziegler-Nichols.
                Τα αποτελέσματα παρείχαν σημαντικές πληροφορίες πως ο τομέας της Τεχνητής Νοημοσύνης μπορεί να ανταπεξέλθει σε πολύ μεγάλο βαθμό ικανοποιώντας τα κυριότερα κριτήρια ελέγχου προσφέροντας την απαιτούμενη ευστάθεια, ικανοποιητικό έλεγχο απόκρισης και αντιμετώπισης διαταραχών.
Evaluating the cost-utility of a direct transfer to angiosuite protocol within 6 h of symptom onset in suspected large vessel occlusion patients
Creators: name: Requena, Manuel
name: Seguel-Ravest, Valeska
name: Vilaseca-Jolonch, Andreu
name: Woods, Jacklyn
name: Guijarro, Pablo
name: Ribo, Marc
name: Tomasello, Alejandro
name: Molina, Carlos A.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Plant Biology

description: A direct transfer to angiosuite (DTAS) protocol has shown to be effective and safe by shortening in-hospital workflows and encouraging long-term outcome benefits. To implement DTAS at a new facility, a large organizational effort is necessary. We performed a cost-utility analysis and budget impact analysis (BIA) of the operation of a new angiosuite, primarily dedicated to stroke patients, that allows facilities to approximate the cost implications of utilizing a DTAS pathway. Sixty-one patients who underwent endovascular treatment (EVT) following DTAS were matched for baseline variables to 117 patients who underwent a conventional imaging protocol at a hospital in Catalonia, Spain. An economic model, based on actual data from these patients, was developed to assess the short- and long-term clinical and economic implications of DTAS. In the BIA, the DTAS scenario was gradually implemented for 20% of patients each year until reaching a plateau at 80% of patients in the DTAS pathway. Initial investment and additional organizational costs, €4 million, were taken into consideration to compare the budget impact of the DTAS scenario with no organizational changes over five years. DTAS was associated with better patient functional independence rates (mRS 0–2: 50.9% vs. 41.0%) and a quality-adjusted life-years gain of 0.82 per patient. Despite the additional initial investment, DTAS development was associated with an estimated 10.2% reduction (€14.7 million) of the total costs (€144.5 million). Cost savings were mainly due to long-term associated costs related to patient disability (€13.2 million). The study relies on data obtained from a single-center, and therefore it may be difficult to generalize the findings Our economic model predicts that the implementation of a DTAS program is cost-effective compared with no organizational changes. Our model also predicts better clinical outcomes for patients in terms of functional independence and quality-adjusted life years.
New universality class in percolation on multifractal scale-free planar stochastic lattice
Creators: name: Hassan, M. K.
name: Rahman, M. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We investigate site percolation on a weighted planar stochastic lattice (WPSL) which is a multifractal and whose dual is a scale-free network. Percolation is typically characterized by percolation threshold $p_c$ and by a set of critical exponents $β$, $γ$, $ν$ which describe the critical behavior of percolation probability $P(p)\sim (p_c-p)^β$, mean cluster size $S\sim (p_c-p)^{-γ}$ and the correlation length $ξ\sim (p_c-p)^{-ν}$. Besides, the exponent $τ$ characterizes the cluster size distribution function $n_s(p_c)\sim s^{-τ}$ and the fractal dimension $d_f$ the spanning cluster. We obtain an exact value for $p_c$ and for all these exponents. Our results suggest that the percolation on WPSL belong to a new universality class as its exponents do not share the same value as for all the existing planar lattices.
description: 5 pages, 5 figures
Protease-activated receptor 4 protects mice from Coxsackievirus B3 and H1N1 influenza A virus infection
Creators: name: Schmedes, C.M.
name: Mackman, N.
name: Tatsumi, K.
name: Antoniak, S.
name: Butler, E.
name: Houston, E.R.
Publisher: name: Academic Press Inc.
Year: 2019

description: PAR4 is expressed by a variety of cells, including platelets, cardiac, lung and immune cells. We investigated the contribution of PAR4 to viral infections of the heart and lung. Toll-like receptor (TLR) 3-dependent immune responses were analyzed after co-stimulation of PAR4 in murine bone-marrow derived macrophages, embryonic fibroblasts and embryonic cardiomyocytes. In addition, we analyzed Coxsackievirus B3 (CVB3) or H1N1 influenza A virus (H1N1 IAV) infection of PAR4−/− (ΔPAR4) and wild-type (WT) mice. Lastly, we investigated the effect of platelet inhibition on H1N1 IAV infection. In vitro experiments revealed that PAR4 stimulation enhances the expression of TLR3-dependent CXCL10 expression and decreases TLR3-dependent NFκB-mediated proinflammatory gene expression. Furthermore, CVB3-infected ΔPAR4 mice exhibited a decreased anti-viral response and increased viral genomes in the heart leading to more pronounced CVB3 myocarditis compared to WT mice. Similarly, H1N1 IAV-infected ΔPAR4 mice had increased immune cell numbers and inflammatory mediators in the lung, and increased mortality compared with infected WT controls. The study showed that PAR4 protects mice from viral infections of the heart and lung.
The factor Xa inhibitor rivaroxaban reduces cardiac dysfunction in a mouse model of myocardial infarction
Creators: name: Grover, S.P.
name: Subramaniam, S.
name: Andrade-Gordon, P.
name: Antoniak, S.
name: Bode, M.F.
name: Rennie, A.
name: Auriemma, A.C.
name: Hisada, Y.
name: Cooley, B.
name: Mackman, N.
name: Bode, W.D.
name: Vora, R.
Publisher: name: Elsevier Ltd
Year: 2018

description: Introduction: Rivaroxaban selectively inhibits factor Xa (FXa), which plays a central role in blood coagulation. In addition, FXa activates protease-activated receptor-2 (PAR-2). We have shown that PAR-2 −/− mice exhibit less cardiac dysfunction after cardiac injury. Material and methods: Wild-type (WT) and PAR-2 −/− mice were subjected to left anterior descending artery (LAD) ligation to induce cardiac injury and heart failure. Mice received either placebo or rivaroxaban chow either starting at the time of surgery or 3 days after surgery and continued up to 28 days. Cardiac function was measured by echocardiography pre-surgery and 3, 7 and 28 days after LAD ligation. We also measured anticoagulation, intravascular thrombi, infarct size, cardiac hypertrophy and inflammation at various times. Results: Rivaroxaban increased the prothrombin time and inhibited the formation of intravascular thrombi in mice subjected to LAD ligation. WT mice receiving rivaroxaban immediately after surgery had similar infarct sizes at day 1 as controls but exhibited significantly less impairment of cardiac function at day 3 and beyond compared to the placebo group. Rivaroxaban also inhibited the expansion of the infarct at day 28. Rivaroxaban did not significantly affect the expression of inflammatory mediators or a neutrophil marker at day 2 after LAD ligation. Delaying the start of rivaroxaban administration until 3 days after surgery failed to preserve cardiac function. In addition, rivaroxaban did not reduce cardiac dysfunction in PAR-2 −/− mice. Conclusions: Early administration of rivaroxaban preserves cardiac function in mice after LAD ligation.
(509) John Turner
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Rao-Blackwellized particle smoothers for conditionally linear Gaussian models
Creators: name: Lindsten, Fredrik
name: Bunch, Pete
name: Särkkä, Simo
name: Schön, Thomas B.
name: Godsill, Simon J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computation (stat.CO)
subject: FOS: Computer and information sciences

description: Sequential Monte Carlo (SMC) methods, such as the particle filter, are by now one of the standard computational techniques for addressing the filtering problem in general state-space models. However, many applications require post-processing of data offline. In such scenarios the smoothing problem--in which all the available data is used to compute state estimates--is of central interest. We consider the smoothing problem for a class of conditionally linear Gaussian models. We present a forward-backward-type Rao-Blackwellized particle smoother (RBPS) that is able to exploit the tractable substructure present in these models. Akin to the well known Rao-Blackwellized particle filter, the proposed RBPS marginalizes out a conditionally tractable subset of state variables, effectively making use of SMC only for the "intractable part" of the model. Compared to existing RBPS, two key features of the proposed method are: (i) it does not require structural approximations of the model, and (ii) the aforementioned marginalization is done both in the forward direction and in the backward direction.
Additional file 2 of Bioassays for the evaluation of the attractiveness of attractive targeted sugar bait (ATSB) against Anopheles mosquitoes in controlled semi-field systems
Creators: name: Tenywa, Frank S. C.
name: Kibondo, Ummi A.
name: Entwistle, Julian
name: Dogan, Osward
name: Haruna, Mapipi
name: Phisoo, Restuta P.
name: Moore, Jason
name: Machange, Jane J.
name: Makame, Haji
name: Tripet, Frederic
name: Müller, Pie
name: Mondy, Mathias
name: Nimmo, Derric
name: Stevenson, Jennifer C.
name: Moore, Sarah J.
Publisher: name: figshare
Year: 2025
Subjects: subject: Cell Biology
subject: Neuroscience
subject: Ecology
subject: FOS: Biological sciences
subject: Mental Health

description: Supplementary Material 2.
Dephasing due to nuclear spins in large-amplitude electric dipole spin resonance
Creators: name: Chesi, Stefano
name: Yang, Li-Ping
name: Loss, Daniel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We have analyzed effects of the hyperfine interaction on electric dipole spin resonance when the amplitude of the quantum-dot motion becomes comparable or larger than the quantum dot's size. Away from the well known small-drive regime, the important role played by transverse nuclear fluctuations leads to a gaussian decay with characteristic dependence on drive strength and detuning. A characterization of spin-flip gate fidelity, in the presence of such additional drive-dependent dephasing, shows that vanishingly small errors can still be achieved at sufficiently large amplitudes. Based on our theory, we analyze recent electric-dipole spin resonance experiments relying on spin-orbit interactions or the slanting field of a micromagnet. We find that such experiments are already in a regime with significant effects of transverse nuclear fluctuations and the form of decay of the Rabi oscillations can be reproduced well by our theory.
description: 6 pages, 4 figures
Sonic shrinking of Pickering-stabilised ultrasound contrast agent at a low acoustic amplitude
Creators: name: Anderton, Nicole
name: Carlson, Craig
name: Matsumoto, Ryunosuke
name: Shimizu, Ri-ichiro
name: Poortinga, Albert T.
name: Kudo, Nobuki
name: Postema, Michiel
Publisher: name: arXiv
Year: 2023
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Ultrasound contrast agents comprise gas microbubbles surrounded by stabilising elastic or viscoelastic shells. Microbubbles containing liquid or solid cores are referred to as antibubbles. The manufacturing process of long-lived antibubbles involves the adsorption of colloidal particles at the interfaces, a process called Pickering stabilisation. With and without cores present inside, Pickering-stabilised microbubbles generate a harmonic response, even at modest transmission amplitudes. Therefore, Pickering-stabilised ultrasound contrast agents may be of interest in contrast-enhanced ultrasonic imaging. In a previous study, we determined that the presence of a core inside Pickering-stabilised microbubbles slightly hampered the oscillation amplitude compared to identical microbubbles without a core. The purpose of the present study is to determine whether the absence of a core negatively influences the stability of Pickering-stabilised microbubbles under sonication.
description: 6 pages, 3 figures, submitted to the 42th Symposium on UltraSonic Electronics (USE2021)
Evaluating the cost-utility of a direct transfer to angiosuite protocol within 6 hours of symptom onset in suspected large vessel occlusion patients
Creators: name: Requena, Manuel
name: Seguel, Valeska
name: Vilaseca-Jolonch, Andreu
name: Woods, Jacklyn
name: Guijarro, Pablo
name: Ribo, Marc
name: Tomasello, Alejandro
name: Molina, Carlos A.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Plant Biology

description: A direct transfer to angiosuite (DTAS) protocol has shown to be effective and safe by shortening in-hospital workflows and encouraging long-term outcome benefits. To implement DTAS at a new facility a large organizational effort is necessary. We performed a cost-utility analysis and budget impact analysis (BIA) of the operation of a new angiosuite, primarily dedicated to stroke patients, that allows facilities to approximate the cost implications of utilizing a DTAS pathway. Sixty-one patients who underwent endovascular treatment (EVT) following DTAS were matched for baseline variables to 117 patients who underwent a conventional imaging protocol at a hospital in Catalonia, Spain. An economic model, based on actual data from these patients, was developed to assess the short and long-term clinical and economic implications of DTAS. In the BIA, the DTAS scenario was gradually implemented for 20% of patients each year until reaching a plateau at 80% of patients in the DTAS pathway. Initial investment and additional organizational costs, €four million, were taken into consideration to compare the budget impact of the DTAS scenario with no organizational changes over 5 years. DTAS was associated with better patient functional independence rates (mRS 0-2: 50.9% vs 41.0%) and a quality-adjusted life-years gain of 0.82 per patient. Despite the additional initial investment, DTAS development was associated with an estimated 10.2% reduction (€14.7 million) of the total costs (€144.5 million). Cost savings were mainly due to long-term associated costs related to patient disability (€13.2 million). The study relies on data obtained from a single-center therefore it may be difficult to generalize the findings Our economic model predicts that the implementation of a DTAS program is cost-effective compared to no organizational changes. Our model also predicts better clinical outcomes for patients in terms of functional independence and quality-adjusted life years.
Protease-activated receptor 1 activation enhances doxorubicin-induced cardiotoxicity
Creators: name: Mackman, N.
name: Tatsumi, K.
name: Grover, S.P.
name: Antoniak, S.
name: Pawlinski, R.
name: Schmedes, C.M.
Publisher: name: Academic Press
Year: 2018

description: Objective: The anti-cancer anthracycline drug Doxorubicin (Dox) causes cardiotoxicity. We investigated the role of protease-activated receptor 1 (PAR-1) in Dox-induced cardiotoxicity. Methods and results: In vitro experiments revealed that PAR-1 enhanced Dox-induced mitochondrial dysfunction, reactive oxygen species and cell death of cardiac myocytes and cardiac fibroblasts. The contribution of PAR-1 to Dox-induced cardiotoxicity was investigated by subjecting PAR-1−/− mice and PAR-1+/+ mice to acute and chronic exposure to Dox. Heart function was measured by echocardiography. PAR-1−/− mice exhibited significant less cardiac injury and dysfunction compared to PAR-1+/+ mice after acute and chronic Dox administration. PAR-1−/− mice had reduced levels of nitrotyrosine, apoptosis and inflammation in their heart compared to PAR-1+/+ mice. Furthermore, inhibition of PAR-1 in wild-type mice with vorapaxar significantly reduced the acute Dox-induced cardiotoxicity. Conclusion: Our results indicate that activation of PAR-1 contributes to Dox-induced cardiotoxicity. Inhibition of PAR-1 may be a new approach to reduce Dox-induced cardiotoxicity in cancer patients.
RESEARCH ON THE COMPARED SPECTRA OF LITTORINA-SAXATILIS AND LITTORINA-NIGROLINEATA LIVING ON INTER-TIDAL SHORES OF ROSCOFF .2. POPULATIONS AMONG MACROSCOPIC ALGAE
Creators: name: Sacchi, C. F.
name: Ambrogi, A. O.
name: Voltolina, D.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1981

Abstract
Exemplars and Counterexemplars Explanations for Image Classifiers, Targeting Skin Lesion Labeling
Creators: name: Metta, Carlo
name: Guidotti, Riccardo
name: Yin, Yuan
name: Gallinari, Patrick
name: Rinzivillo, Salvatore
Publisher: name: arXiv
Year: 2023
Subjects: subject: Image and Video Processing (eess.IV)
subject: Artificial Intelligence (cs.AI)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Machine Learning (cs.LG)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: Explainable AI consists in developing mechanisms allowing for an interaction between decision systems and humans by making the decisions of the formers understandable. This is particularly important in sensitive contexts like in the medical domain. We propose a use case study, for skin lesion diagnosis, illustrating how it is possible to provide the practitioner with explanations on the decisions of a state of the art deep neural network classifier trained to characterize skin lesions from examples. Our framework consists of a trained classifier onto which an explanation module operates. The latter is able to offer the practitioner exemplars and counterexemplars for the classification diagnosis thus allowing the physician to interact with the automatic diagnosis system. The exemplars are generated via an adversarial autoencoder. We illustrate the behavior of the system on representative examples.
description: arXiv admin note: text overlap with arXiv:2111.11863
Cirripeds (Crustacea) from the Mid-Atlantic Ridge collected by the submersible Nautile
Creators: name: YOUNG, Paulo S.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1998

description: Nine species of barnacles were dredged along the Mid-Atlantic Ridge during several cruises of the French
 submersible Nautile. They include the lepadomorph Glyptelasma rectum, the scalpellomorphs Scillaelepas sp.,
 Trianguloscalpellum regium, Arcoscalpellum michelottianum, the verrucomorphs Altiverruca erecta, A. longicarinata,
 A. obliqua, and the balanomorph Hexelasma americanum. A new verrucomorph Newmaniverruca ferruginea sp. nov. is
 described. Altiverruca erecta and A. longicarinata are redescribed. All these species have a wide distribution, except
 A. erecta and N. ferruginea sp. nov. Based on several recent studies it now appears that Atlantic hydrothermal vents areas
 are not refugia for unusual relic cirripeds such as those found in the Pacific hydrothermal fields.
Tissue factor and oxidative stress
Creators: name: Mackman, N.
name: Antoniak, S.
Publisher: name: American Society of Hematology
Year: 2018

description: In this issue of Blood, Ebert et al conclude that endothelial cell (EC) tissue factor (TF) activity induces a prothrombotic state in mice that lack the antioxidant paraoxonase-2 (PON2).
An examination into the effects of frozen storage of olive fruit on extracted olive oils
Creators: name: Asheri, M.
name: Sharifani, M.M.
name: Kiani, G.
Publisher: name: Advances in Horticultural Science
Year: 2017

description: This study was achieved to examine the effects of freezing olive fruits of the Arbequina, Koroneiki and Mission cultivars (the most common olive oil producing cultivars in Iran) on the standard indices used for assessing virgin olive oil quality. Oil was obtained from olive fruits stored at -4˚C for 1 week and 3 weeks, and compared with oil obtained immediately after harvest (control). The quality indices of oils obtained from frozen fruit showed no significant degradation in quality compared with the control samples. In fact the peroxide value of the frozen fruits decreased compared to the control, which is considered to have a positive effect on oil quality. In addition, compositions of the main fatty acids are not altered by freezing which demonstrate frozen storage as a viable option. Oil derived from frozen olive fruit is not of inferior quality to non-frozen fruit in the production of olive oil.
description: Advances in Horticultural Science, Vol 31 No 3 (2017)
Fundamental rate-loss tradeoff for optical quantum key distribution
Creators: name: Takeoka, Masahiro
name: Guha, Saikat
name: Wilde, Mark M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Since 1984, various optical quantum key distribution (QKD) protocols have been proposed and examined. In all of them, the rate of secret key generation decays exponentially with distance. A natural and fundamental question is then whether there are yet-to-be discovered optical QKD protocols (without quantum repeaters) that could circumvent this rate-distance tradeoff. This paper provides a major step towards answering this question. We show that the secret-key-agreement capacity of a lossy and noisy optical channel assisted by unlimited two-way public classical communication is limited by an upper bound that is solely a function of the channel loss, regardless of how much optical power the protocol may use. Our result has major implications for understanding the secret-key-agreement capacity of optical channels---a long-standing open problem in optical quantum information theory---and strongly suggests a real need for quantum repeaters to perform QKD at high rates over long distances.
description: 9+4 pages, 3 figures. arXiv admin note: text overlap with arXiv:1310.0129
Applications of likelihood-free parameter inference methods on numerical models of cancer invasion
Creators: name: Xiao, Yunchen
Publisher: name: The University of St Andrews
Year: 2022
Subjects: subject: Mathematical biology
subject: Bayesian statistics
subject: QH323.5X5
subject: Biology--Mathematical models

description: In this thesis, we present two different methods to estimate parameters within a Partial Differential Equation (PDE) model of cancer invasion and an Individual-based Model (IBM) derived from it. The PDE model was fitted to synthetic spatial 1D data generated from the model, and the IBM was fitted to authentic spatial 2D data derived from the invasion patterns observed in in vitro and ex vivo organotypic assays. The first estimation method is a likelihood-free approach related to Approximate Bayesian Computation (ABC). The second is a two-stage gradient matching method based on smoothing the data with a Generalized Additive Model (GAM) and matching gradients from the GAM to those from the model. Both methods performed well on spatial 1D synthetic data when the synthetic data was generated assuming no measurement errors. To increase realism we tested both methods with simulated measurement errors, and found that the ability to estimate some model parameters deteriorated rapidly as measurement error increased for the gradient matching method. The ABC method was more robust to the introduction of measurement errors. For spatial 2D authentic data, we only applied the ABC method. The simulated patterns produced at the end of the estimation procedure were quantitatively close to the observed ones. In addition, most of the final parameter samples obtained in the spatial 2D inference passed a set of ABC posterior diagnostics, implying they are valid posteriors from the perspective of Bayesian inference. The ABC-derived calibration methods developed in this thesis are not limited to models of cancer invasion alone, and can potentially be applied in a wide variety of application areas where the system under examination can be described using PDE models.
SUR LA STRUCTURE ET LE RÔLE DES GLANDES VESTIBULAIRES ET SUR LA NATURE DE CERTAINS ORGANES DE LA CAVITÉ CYSTIDIENNE CHEZ LES BRYOZOAIRES CHILOSTOMES
Creators: name: LUTAUD, Geneviève
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1964

description: A first discrimination between the gland-like structures that can be considered as connected with the orifice of the zoecium in Cheilostoma is established by the systematic survey of 53 species from Roscoff. The vestibular glands of the Aseas and some other specific organs included either in the autozoecium or in the avicularium chambers are studied together.
1.—The vestibular glands studied by histochemistry in Schizobrachiella sanguinea (Norman) produce a mucous secretion in the area where the tentacles emerge. They develop from two lateral thickenings in the upper part of the embryonic tentacular sheath. Their evolution through the group is directed towards an increase in volume and the différenciation of two cytologically and functionally distinct regions.
2.—The specific bodies of the autozoecium cavity in Figularia figularis (Johnston)and S. sanguinea are unpaired organs hanging from the margin of the orifice. They are anatomically independent of any other cystidian or polypidian organ. They develop from an évagination of the vestibule wall and undergo cyclical regeneration, but the phases of this renovation may differ from the polypid regeneration periodicity. Similar, though paired, bodies exist also in the avicularium of Porella concinna (Busk).
In the three species, the specific bodies are made of a thin cellular sheath filled with an internal anhistous mass ; this internal part is itself made of two different elements : the first one appears in the live isolated organ either as a granular heap (F. figularis) or as a matting of entangled threads (S. sanguinea) or short rods (P. concinna) ; the second one is a protidic or mucoidic substance either diffused (F. figularis and P. concinna) or included within internal cells (S. sanguinea) and can be considered as the product of the functionally active organ.
The first component exhibits after enzymatic control both the histochemical characters of the ribonucleins stained by pyronin and the Feulgen positive reaction of chromatin. Such histochemical featu
(510) Janet [Turner]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Letter to Editor response: Endothelial cell tissue factor and coagulation
Creators: name: Mackman, N.
name: Antoniak, S.
Publisher: name: Elsevier Inc.
Year: 2017

description: Thank you for the opportunity to respond to the letter by Drs. Witkowski and Rauch about our editorial. It is very challenging moving from in vitro studies with cultured cells to in vivo studies that analyze gene expression. In the tissue factor(TF) field it is well accepted that cultured endothelial cells(EC) do not express TF under basal conditions but can be induced to express TF after stimulation with a variety of agonists. Witkowski and Rauch state that the induction of TF in culture ECs “makes itlikelythatTFderivedfromECs contributes to coagulation under pathological conditions”. However, the models they present in support of arole for ECTF in coagulation are not selective for TF. For instance, over-expression of an NFκB inhibitor or EC-specific knock-out of miR-126 will affect many genes in the endothelium. Interestingly, miR-126 also regulates TF expression in monocytes. Furthermore,blood vessels are surrounded by pericytes, smooth muscle cells and adventitial fibroblasts, all of which express TF. Therefore, it is very difficult to distinguish the contribution of TF expression induced in the endothelium from that exposed on perivascular cells due to disruption of the endothelialbarrier.