cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Melodrama, Liederspiel and Revolution: Robert Schumann’s Domestication of Theater after 1848
Creators: name: Dupuis, Jacques
Publisher: name: Brandeis University
Year: 2021
Subjects: Liederspiel
melodrama
musical genre
musical theater
Robert Schumann
Theater history
Music
Germany

description: Following the 1848 European revolutions, Robert Schumann began a period of prolific composition. Among the pieces he composed for domestic spaces at this time are five opus numbers—Schön Hedwig, op. 106, Zwei Balladen, op. 122, Spanisches Liederspiel, op. 74, Minnespiel, op. 101, and Spanische Liebeslieder, op. 138—that transmit genres traditionally associated with theatre into domestic spaces: melodrama and Liederspiel. I gather these pieces under the designation “domestic dramatic vocal music,” reflecting their connections to theater and intended performance away from it. I argue that the most germane operating theoretical frameworks of these pieces are genre and the public/private dichotomy. In the first chapter of this dissertation, I discern Schumann’s understanding of genre and how he deployed it in his writing and music. The second chapter considers the public/private sphere dichotomy as it pertains to Schumann’s work, as well as its use in the field of musicology more broadly. The third through sixth chapters take these frameworks as groundwork for understanding the characteristic mechanisms of the composer’s work in this music. Chapters three and four are dedicated to relevant melodrama history and analysis of cultural contexts that resonate in Schumann’s melodramatic declamation ballads, opp. 106 and 122. Chapter five considers aspects of the Liederspiel genre from its invention in 1800 onward that pertain to Schumann’s pieces. This chapter also presents a picture of the genre during the second half of the century, yet understudied, with the argument that Schumann contributed to a living genre, not one he revived, as many scholars have explicitly or implicitly argued. Chapter six is dedicated to Schumann’s Liederspiele, opp. 74, 101 and 138, focusing on their significance to those close to the composer, their reception history, and close readings for cultural and nationalistic political resonances. In the epilogue, I argue that these pieces are among those that reflect Schumann’s perspective on the midcentury European revolutions, and particularly emphasize individual personal experience.
The small RNA landscape is stable with age and resistant to loss of FOXO signaling in Drosophila
Creators: name: Gartland, Siobhan
Publisher: name: Brandeis University
Year: 2023
Subjects: argonaute
FOXO
RNA interference
Aging

description: Aging is the overall decline of cellular processes with time and recent work has shown that small RNA pathways are involved in aging in many ways. Small RNAs play important roles in development, cellular physiology, and innate immunity by inhibiting complementary RNAs with the aid of RNA induced silencing complexes (RISC) in RNA interference (RNAi). There are two RNAi pathways in the somatic tissue of Drosophila melanogaster: the microRNA (miRNA) pathway and the small interfering RNA (siRNA) pathway. Argonaute1 (Ago1) is the core component of the miRNA RISC while Argonaute2 (Ago2) is the core component of the siRNA RISC. siRNA silencing efficiency is increased by the stress response transcription factor Forkhead box O (FOXO). FOXO responds to many stress pathways that have important implications for aging and lifespan. In the siRNA pathway, FOXO regulates Ago2 and the upstream processing enzyme Dicer-2 which produces siRNAs, while the only known FOXO targets in the miRNA pathway include RISC components and no processing enzymes. Because of this asymmetry, we speculated that FOXO may be able to alter the contents of argonaute RISC and therefore the total small RNA landscape as well, particularly as animals age. Here, we used next generation sequencing to investigate changes in small RNA abundance and RISC loading with age in male and female Drosophila. To our knowledge, these are the first small RNA libraries from Ago1 and Ago2 RISC in female Drosophila and the only comparison of sequencing libraries between total small RNA and RISC loaded RNA. We also assessed how the loss of FOXO could affect the aging small RNA landscape. We found that the majority of small RNAs do not change with age. The landscape is largely resistant to loss of FOXO but the loading of a few small RNAs in RISC is changed.
An urgent call for resilient WASH solutions at fish landing sites
Creators: name: Manga, Musa
name: Semanda, Judith Nanyondo
name: Kwiringira, Andrew
name: Lebu, Sarah
name: Fred, Tusabe
name: Makena, Mugambi Evelyn
name: Kesande, Maureen
Publisher: name: Public Library of Science
Year: 2024

description: Access to safe water, sanitation and hygiene (WASH) is the most basic human need for health and well-being. Globally, it’s estimated that around 600 million people depend on fisheries and aquaculture for their livelihoods, many of whom reside in coastal and fish landing site communities. Fish landing sites are often located at the interface of land and water where they are directly exposed to variations in water levels. Unlike other flood-prone areas, fish landing sites are proximal to water bodies and low-lying terrains making them vulnerable to the regular occurrence of floods that overwhelm existing WASH systems, making them unreliable or completely non-functional during critical times. The combination of significant organic waste from fish processing with floodwaters leads to serious water quality issues, such as contamination of drinking water sources, increased risk of waterborne diseases like cholera, and ecosystem disruptions via algal blooms. Additionally, these sites are highly susceptible to frequent infrastructure inundation, further contamination of water sources, and substantial damage to sanitation facilities. Despite the poor WASH infrastructure risk factors, most research has focused on fish catch reduction and unsanitary processing practices that expose fishing communities to pathogens. While this focus is essential for understanding food safety, it overlooks a critical aspect of public health—resilient sanitation and hygiene infrastructure in fishing communities. In this article, we provide expert opinions to enhance WASH infrastructure and practice resilience for better health outcomes in fishing communities.
'The Thin Black Line': Black comedy and its descent from subversive comic provocation to mainstream inglorious offence
Creators: name: Beck, Chris
Publisher: name: Swinburne
Year: 2024

description: This thesis examines whether black comedy still lampoons influential institutions and probes social mores with sharp satire and strong language or simply aims to offend for its own sake. It questions whether the freedom of speech that comedians in the 1960s advocated to defend their social and political subversion is now assumed, as a right, by comedians for the less edifying practice of humiliating people and targeting the vulnerable.
The effects of ambient temperature on post-exercise blood pressure.
Creators: name: Dottori, Tracy E.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Biology, Animal Physiology.

description: Although the cardiovascular changes associated with dynamic exercise have been investigated, there still remain many unanswered questions with respect to blood pressure following exercise. This study examined the effect of temperature on systolic (SBP), diastolic blood pressure (DBP), heart rate (HR), oxygen consumption $\rm(VO\sb2),$ and skin temperature (Tsk) in 10 healthy, young males (23-28 years of age), during a 60-minute supine post-exercise recovery period. On separate occasions, 20 minutes of treadmill exercise at heart rate of 140 beats per minute, preceded a 60-minute recovery period in a supine position conducted at either $\rm18\sp\circ C,\ 27\sp\circ C,\ or\ 40\sp\circ C.$ Results indicated that mean SBP was significantly more above baseline values at $\rm18\sp\circ C$ than at either $\rm27\sp\circ C\ or\ 40\sp\circ C.$ However, no significant difference in SBP was observed between recovery at $\rm27\sp\circ C\ and\ 40\sp\circ C.$ Also, no significant differences were observed among the three conditions for mean DBP. HR decreased progressively during recovery but remained above baseline values, except at $\rm18\sp\circ C$. No significant differences among recovery conditions were observed for $\rm VO\sb2.$ Mean skin temperatures were significantly different among the three recovery conditions except immediately upon entering the chamber. It was concluded that recovery at $\rm18\sp\circ C$ maintained post-exercise SBP above baseline values while $\rm27\sp\circ C\ and\ 40\sp\circ$C caused a decrease in post-exercise SBP with respect to baseline values. DBP and $\rm VO\sb2$ during recovery were not influenced by temperature. HR decreased gradually post-exercise with the lowest HR observed during cold exposure. Therefore, for the conditions of this experiment temperature had a significant effect on SBP, HR and skin temperature all of which effectively appeared to be associated with peripheral vasodilation/constriction mechanisms.
Kitsap County 4-H Newsletter, September 2020
Creators: name: Washington State University Kitsap County Extension
Publisher: name: Washington State University
Year: 2020
Subjects: 4-H Club

description: Contents:
description: Important Dates
description: In the Spotlight
description: 4-H in Kitsap County
description: State & National 4-H Opportunities
description: 4-H Fundraisers
description: Scholarship Opportunities
description: Volunteer News
description: 4-H Office Contact Information
Insulin and TSH signal transduction pathways in human preadipocytes.
Creators: name: Bell, Andrea Dorothy Lee.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Biology, Cell.

description: Signaling through the rapamycin-sensitive mammalian target of rapamycin-p70 S6 kinase (p70 S6K) pathway was examined in human preadipocytes in primary culture. The inhibitory effect of rapamycin on insulin-induced differentiation of preadipose cell lines has been attributed to a blockade of clonal expansion. We demonstrate that rapamycin inhibits the differentiation of human preadipocytes in primary culture, even though these cells do not undergo clonal expansion. Glycerol-3-phosphate-dehydrogenase (GPDH) activity, an indicator of differentiation, was reduced in omental and subcutaneous preadipocytes to 17 +/- 10% (mean +/- 95% confidence limits, n = 10) of standard differentiation. Our data suggest rapamycin-sensitive pathways operate independently of clonal expansion. Our second objective addressed a novel route of p70 S6K activation. We have detected the presence of TSH receptor in human preadipocytes, and have shown it activates PKB and p70 S6K in a wortmannin-sensitive manner. A model depicting the convergence of insulin and TSH signaling in human preadipocytes is proposed.
DISSECTING CONTRIBUTIONS OF QUINOA AND BUCKWHEAT TO AGROECOSYSTEM AND HUMAN HEALTH
Creators: name: Breslauer, Rachel Sarah
Publisher: name: Washington State University
Year: 2025
Subjects: Quinoa
Buckwheat
Essential Amino Acid
Crop rotation
Edible Seed Crops

description: No addition to a crop rotation is a silver bullet for addressing concerns about food security, nutrition, and cropping system resilience. New food crops can add functional diversity into an agroecosystem and food system but are rarely monoliths in their contributions. This dissertation attempts to advance our understanding of the value that quinoa (Chenopodium quinoa Willd.) and buckwheat (Fagopyrum esculentum Moench.) can bring as novel features of western Washington (WWA) crop rotations.
description: Quinoa seed proteins have essential amino acid (EAA) profiles that are close to human requirements, but there are many examples of quinoa failing to meet the human requirements for individual EAA. In a controlled environment study, we found that low mid-season nitrogen supply can cause low levels of isoleucine, leucine, and valine in quinoa seed. This study underscored the importance of managing soil fertility to maintain high-quality quinoa seed protein. We then explored the sensitivity of quinoa EAA to planting date in a WWA field study. This study was the first evaluation of EAA of field-grown quinoa for which all samples met adult EAA requirements. Planting date primarily affected overall protein content but did not affect EAA composition. The small differences in EAA observed in this study were attributed to the effect of variety and year.
description: Buckwheat is an edible seed crop that is a common choice as a weed-suppressive cover crop in organic systems. Historically it has rarely been grown to seed in WWA and there is consequently limited production guidance for prospective growers in this region. A review of buckwheat production potential in WWA identified flooding sensitivity and heat sensitivity at seed set as key emerging production challenges in the region. This review was adapted into a production guide to provide resources to beginning buckwheat producers in WWA.
description: The final portion of this dissertation considers the potential for breeding buckwheat and other edible seed crops (ESC) for providing multiple ecosystem services in WWA cropping systems. A baseline study of multifunctional performance of commercial buckwheat varieties in WWA found few differences in yield. However there were distinct differences in the onset of flowering and maturity as well as preliminary evidence that weed suppressive ability is variety-dependent. A survey of ESC producers in WWA found that across production scales, these producers grew ESC both as cash crops and to support soils in their systems. This study revealed that ESC producers use these crops to support nutrient cycling, soil formation, and fixing carbon into organic matter.
description: Together, these studies highlight opportunities to improve management strategies and breeding targets for quinoa and buckwheat as novel crops in WWA.
3046222.pdf
Creators: name: Saastamoinen, Kimmo
name: Leppänen, Lasse-Petteri
name: Vartiainen, Ismo
name: Friberg, Ari Tapio
name: Setala, Tero
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental document on used methods, analysis and fabrication.
Taking the repeats: Modern American poetry in imitation of eighteenth-century musical forms.
Creators: name: Richardson, C. Scott.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Literature, Modern.

description: This dissertation surveys the various efforts by modern American poets to imitate the repetitive structures of eighteenth-century instrumental music, setting in a wider historical context some of the central achievements of the twentieth-century long poem, as well as offering readings of some lesser-known but interesting works that draw on musical structures and processes as their formal models. The introduction examines why such disparate poets have wished to organize their work through some analogue to musical form. Taking their cues from western instrumental composition, writers have let the shapes of their poems be determined not by the demands of narrative for succession or the demands of discursive argument for progressive development but instead by music's repetitive imperative. In musical structures such as the variation set, the fugue, and the sonata, poets found constructive techniques congenial to the twentieth-century mind. Eighteenth-century musical genres can be seen as anticipating in a remarkable manner modern ideas concerning the circular patterns of thought and experience. The first chapter examines poetry modeled on the variation set, surveying works by Randall Jarrell, Wallace Stevens, Harry Mathews, Charles Olson, and Frank O'Hara. The second chapter deals with poetic fugues, including works by May Sarton, William Bronk, Weldon Kees, Delmore Schwartz, and Sylvia Plath. It also examines the validity of fugal analogies at both the macro- and micro-level of analysis in two key modern long poems, Ezra Pound's Cantos and Louis Zukofsky's "A". The final chapter examines poetic versions of sonata forms, including the sonata-based genres of symphony and quartet. It deals with works by Donald Justice, Conrad Aiken, John Gould Fletcher, Stevens, W. C. Williams, and John Ashbery. T. S. Eliot is central to the discussion: the chapter reexamines the validity of musical analogy in relation to Four Quartets and places Eliot's achievement in historical context, as a culmination of earlier currents and as a dominant presence in later musically-patterned poetry.
Unveil hidden gems: Improving discoverability of Ming Qing Women Poets and their poetry works through Wikidata
Creators: name: Heng, Greta
name: Deng, Sai
name: Zhu, Lihong
Publisher: name: Washington State University
Year: 2023
Subjects: Chinese culture and heritage
Chinese women poets
Cultural heritage collections
Linked data in libraries
Linked open data
Wikidata
WikiProject

description: Traditionally, special collections featuring cultural heritage materials, and related authority data on authors and works, have been created using conventional cataloging standards with limited data interoperability. To increase accessibility and visibility of Chinese cultural heritage data, a group of Chinese American librarians created the Wikidata:WikiProject Chinese Culture and Heritage in 2020. This project utilized Wikidata's Linked Open Data (LOD) platform to create, share, and reuse data. Specifically, the project members added and enriched entries over 4,000 poets and 160 poetry works in Wikidata. By using Wikidata SPARQL service and its visualization tools, the project succeeded in visualizing the relationships between various entities, such as poets, places, and works, and generating graph views for women poets' biological information. This poster presentation aims to provide an overview of the project, highlighting the challenges faced and how the LOD approach contributed to better information discovery for cultural heritage collections. Additionally, this poster will demonstrate the project's impact, showcase its achievements, and outline future plans. As evidence of its success, the project received Special Recognition in 2022 as part of the Chinese American Librarians Association's 50th Anniversary CALASYS Grant and has garnered positive feedback from the community.
Exploring Mechanisms of Rehumanization: Can Cognitive-Based Compassion Training Reduce Blatant Dehumanization?
Creators: name: Mikesell, Caley Marie
Publisher: name: Brandeis University
Year: 2024
Subjects: Cognitive-Based Compassion Training
Compassion
Dehumanization
Meditation
Prejudice
Rehumanization

description: Dehumanization is a type of social perception in which we fail to represent another as a full human with whom we can empathize, instead likening them with machines, objects, or animals. Seeing someone as “less-than” absolves the perceiver of the moral obligations they would be expected to abide by when dealing with another person. In turn, this disinhibits actions or attitudes that would otherwise be deemed extreme. For this reason, blatant dehumanization is associated with the worst of intergroup outcomes, including discrimination, mass violence, and genocide. Developing multiple strategies to reduce blatant dehumanization is important given its pervasiveness, the potentially high stakes outcomes with which it is associated, and because no intervention is universally effective in preventing it. Practices that are effective in engaging empathy and reducing some forms of bias, such as meditation, are a promising new category of intervention. For example, Cognitive-Based Compassion Training (CBCT), a secularized compassion meditation training, has been used to improve empathic accuracy, and similar interventions have yielded a reduction in some types of bias. To make the case that CBCT should be piloted as a rehumanization intervention, this review begins with an overview of what blatant dehumanization is, why people engage in it, how it arises, and why it is distinct from other forms of prejudice. Then, it describes existing interventions, proposes CBCT as an outgroup-independent rehumanization strategy, and theorizes potential mechanisms of change. These include decoupling automatic dehumanization from current perception, promoting connection, empathic accuracy, and security, and priming the perceiver for different social interactions via attitudinal, behavioral, neural, and somatic changes. Finally, it discusses how CBCT may overcome initial resistance to intervention and negotiate moral pitfalls in ways that other strategies may not be suited to do and concludes with limitations.
Kitsap County 4-H Newsletter, November 2020
Creators: name: Washington State University Kitsap County Extension
Publisher: name: Washington State University
Year: 2020
Subjects: 4-H Club

description: Contents:
description: Important Dates
description: In the Spotlight
description: 4-H in Kitsap County
description: State & National 4-H Opportunities
description: 4-H Fundraisers
description: Scholarship Opportunities
description: Volunteer News
description: 4-H Office Contact Information
Marketing for AIDS prevention: What gay men's autobiographical life histories tell us about the role of altruism and the moral norm
Creators: name: Campbell, Gordon
Publisher: name: Swinburne
Year: 2024

description: Cost of HIV/AIDS to Australian society is high and increasing. The need; increase adherence to behaviours that prevent transmission of the HIV virus to gay men, the most at-risk population. Sixteen gay men from the Melbourne gay milieu provided their autobiographical life histories. Analysis identified how they initially form and then maintain their attitudes towards preventative behaviours. Additionally, they held a moral norm enabling them to behave altruistically to achieve values important to them. Contribution to society; models identified that provide managerial direction for the design of promotions for preventative behaviours. Recommendations follow for further research and trials of promotional concepts.
Activation of polycystin-1 signaling by binding of stalk-derived peptide agonists
Creators: name: Miao, Yinglong
name: Magenheimer, Brenda S
name: Maser, Robin L
name: Joshi, Keya
name: Pawnikar, Shristi
name: Haldane, Allan
name: Nevarez-Munoz, Ericka
Publisher: name: eLife
Year: 2024

description: Polycystin-1 (PC1) is the protein product of the PKD1 gene whose mutation causes autosomal dominant Polycystic Kidney Disease (ADPKD). PC1 is an atypical G protein-coupled receptor (GPCR) with an autocatalytic GAIN domain that cleaves PC1 into extracellular N-terminal and membrane-embedded C-terminal (CTF) fragments. Recently, activation of PC1 CTF signaling was shown to be regulated by a stalk tethered agonist (TA), resembling the mechanism observed for adhesion GPCRs. Here, synthetic peptides of the first 9- (p9), 17- (p17), and 21-residues (p21) of the PC1 stalk TA were shown to re-activate signaling by a stalkless CTF mutant in human cell culture assays. Novel Peptide Gaussian accelerated molecular dynamics (Pep-GaMD) simulations elucidated binding conformations of p9, p17, and p21 and revealed multiple specific binding regions to the stalkless CTF. Peptide agonists binding to the TOP domain of PC1 induced close TOP-putative pore loop interactions, a characteristic feature of stalk TA-mediated PC1 CTF activation. Additional sequence coevolution analyses showed the peptide binding regions were consistent with covarying residue pairs identified between the TOP domain and the stalk TA. These insights into the structural dynamic mechanism of PC1 activation by TA peptide agonists provide an in-depth understanding that will facilitate the development of therapeutics targeting PC1 for ADPKD treatment.
Mild hypothermia provides Treg stability
Creators: name: Marek-Trzonkowska, Natalia
name: Piekarska, Karolina
name: Filipowicz, Natalia
name: Piotrowski, Arkadiusz
name: Gucwa, Magdalena
name: Vogt, Katrin
name: Sawitzki, Birgit
name: Siebert, Janusz
name: Trzonkowski, Piotr
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Applied immunology
subject: Immunology
subject: FOS: Clinical medicine
subject: Methylation
subject: Regulatory T cells
subject: Translational research
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten

description: Regulatory T cells (Tregs) play crucial role in maintenance of peripheral tolerance. Recent clinical trials confirmed safety and efficacy of Treg treatment of deleterious immune responses. However, Tregs lose their characteristic phenotype and suppressive potential during expansion ex vivo. Therefore, multiple research teams have been studding Treg biology in aim to improve their stability in vitro. In the current paper, we demonstrate that mild hypothermia of 33 °C induces robust proliferation of Tregs, preserves expression of FoxP3, CD25 and Helios, and prevents TSDR methylation during culture in vitro. Tregs expanded at 33 °C have stronger immunosuppressive potential and remarkably anti-inflammatory phenotype demonstrated by the whole transcriptome sequencing. These observations shed new light on impact of temperature on regulation of immune response. We show that just a simple change in temperature can preserve Treg stability, function and accelerate their proliferation, responding to unanswered question- how to preserve Treg stability in vitro.
A Retributive Rescue of Plea Bargaining
Creators: name: Schwartz, Michael Ezra
Publisher: name: Brandeis University
Year: 2023
Subjects: Plea Bargaining
Retributivism
Punishment
Legal Theory
Criminal Justice
Legal Procedure

description: Though every criminal defendant in the United States is entitled to a trial in which their innocence is presumed, in reality, few defendants exercise their right to trial today. Instead, the main method of criminal case resolution is the guilty plea, which is often reached as the result of a plea bargain. The central question of this thesis is whether any or all of the various types of plea bargaining procedures align with the normative foundations of criminal punishment. In particular, I analyze plea bargaining through the lens of Jean Hampton's expressive retributivism.
description: The scholarly consensus to date is that plea bargaining violates retributive principles of proportionality in punishment, because two people who commit the same crime may face vastly different sentences depending on whether they were convicted at trial or received their sentence after pleading guilty. Therefore, it is argued, a scheme of criminal punishment can either be retributivist or feature plea bargaining but cannot do both. In this thesis, I challenge that consensus by arguing that the guilty plea that comes as a part of each plea bargain carries normative weight. In particular, I argue that the guilty plea essentially accomplishes the same retributive goals as punishment. To use Hampton's language, while punishment accomplishes diminishment performed by the state, I make the case that the guilty plea accomplishes self-diminishment. Therefore, we do not have to abandon a retributive theory of punishment to justify at least some types of plea bargaining.
The Reward of Oscillating: A Life of Distortion
Creators: name: Patrick Carodine
Publisher: name: Unified Theistic Naturalism
Year: 2025

description: Oscillation is not failure. It is reward. The sufferer and seeker who move in and out of presence are not punished by the Divine. They are rewarded by the material ego and the illusionary ego—with distortion. And distortion, though subtle, is complete. It touches joy, touches peace, touches wisdom—but never holds them.

 

This paper exposes the hidden prize of the one who has not surrendered their movement to Divine cadence. It invites the seeker to observe their life not through meaning, but through movement.
Assembling Green Bonds: Data, Narrative, Time, Work, and People in Climate Finance
Creators: name: Tripathy, Aneil
Publisher: name: Brandeis University
Year: 2021
Subjects: subject: Climate Finance
subject: Green Bonds
subject: Markets
subject: Climate Change
subject: Finance
subject: Anthropology
subject: FOS: Sociology

description: Financial markets occupy a privileged place in the global economy and wield a large and growing influence on public policy and collective decision-making. The developing finance subfields of climate and sustainable finance situate financial markets as both the principal problem and solution to the climate crisis and environmental degradation. The financial industry continues to fund fossil fuels, resource extraction, and social inequalities that produce and exacerbate current environmental, social, and climate crises. In this dissertation, I explore the tension created as climate finance practitioners distinguish the green bond market and climate finance from mainstream finance, while simultaneously attempting to shift mainstream finance towards sustainable investment. I analyze the work and activity through which climate finance and the green bond market have come to exist. This work produces green bonds and the green bond market through its components of data, market narrative, time, work, and climate finance people. Anthropologists of finance and markets highlight and trace the embeddedness of market dynamics in politics, society, and history. The anthropology of contemporary financial markets employs two dominant forms of analysis. Science and Technology Studies scholars meticulously document devices and tools used by market participants, while sociocultural anthropologists focus on lived experiences and cultural worlds. In my analysis of the green bond market, I combine both approaches and further the study of financial market mechanisms and market cultural ethos. I breakdown my study of the green bond market into distinct components while connecting these components together through the larger societal dynamics of climate finance and the green bond market. The composite of data, narrative, time, work, and people in the green bond market produces a new ethical field that is contested through explicit discussion on the purpose of financial markets. This ethical field shows financial markets to be a contested and diverse space. Given the outsized role of finance in society, identifying the fissures made possible by climate finance may grow in importance as the climate crisis intensifies.
3046222.pdf
Creators: name: Saastamoinen, Kimmo
name: Leppänen, Lasse-Petteri
name: Vartiainen, Ismo
name: Friberg, Ari Tapio
name: Setala, Tero
Publisher: name: Optica Publishing Group
Year: 2018
Subjects: Uncategorized

description: Supplemental document on used methods, analysis and fabrication.
Multitarget-directed phytochemicals to combat plaques and tangles in Alzheimer's disease and improving its pharmacokinetics using nanoencapsulation
Creators: name: Christopher, Joanna
Publisher: name: Swinburne
Year: 2024

description: One of the major hurdles facing drug discovery for Alzheimer’s disease (AD) is its multifactorial nature involving several molecular targets that contribute to its etiopathology. Thus, a multitarget ligand was proposed in this study as a promising therapeutic strategy to address the complex nature of AD. The findings indicate that butein, a plant polyphenol, displayed drug-like properties and can modulate multiple targets of AD. In the context of pharmacology, the bioavailability of the compound is crucial for therapeutic implication; the outcomes from this study suggested that the reported polymer-lipid nanoencapsulation was efficient in improving stability, solubility and bioavailability of butein.
Volunteer navigation partnerships: Piloting a compassionate community approach to early palliative care
Creators: name: Pesut, Barbara
name: Duggleby, Wendy
name: Warner, Grace
name: Fassbender, Konrad
name: Antifeau, Elisabeth
name: Hooper, Brenda
name: Greig, Madeleine
name: Sullivan, Kelli
Publisher: name: BioMed Central
Year: 2017

description: Background: A compassionate community approach to palliative care provides important rationale for building community-based hospice volunteer capacity. In this project, we piloted one such capacity-building model in which volunteers and a nurse partnered to provide navigation support beginning in the early palliative phase for adults living in community. The goal was to improve quality of life by developing independence, engagement, and community connections. Methods: Volunteers received navigation training through a three-day workshop and then conducted in-home visits with clients living with advanced chronic illness over one year. A nurse navigator provided education and mentorship. Mixed method evaluation data was collected from clients, volunteer navigators, the nurse navigator, and other stakeholders. Results: Seven volunteers were partnered with 18 clients. Over the one-year pilot, the volunteer navigators conducted visits in home or by phone every two to three weeks. Volunteers were skilled and resourceful in building connections and facilitating engagement. Although it took time to learn the navigator role, volunteers felt well-prepared and found the role satisfying and meaningful. Clients and family rated the service as highly important to their care because of how the volunteer helped to make the difficult experiences of aging and advanced chronic illness more livable. Significant benefits cited by clients were making good decisions for both now and in the future; having a surrogate social safety net; supporting engagement with life; and ultimately, transforming the experience of living with illness. Overall the program was perceived to be well-designed by stakeholders and meeting an important need in the community. Sustainability, however, was a concern expressed by both clients and volunteers. Conclusions: Volunteers providing supportive navigation services during the early phase of palliative care is a feasible way to foster a compassionate community approach to care for an aging population. The program is now being implemented by hospice societies in diverse communities across Canada.
Generative Adversarial Networks for Multi-Objective Synthetic Data Generation
Creators: name: DeSmet, Chance Nicholas
Publisher: name: Washington State University
Year: 2024
Subjects: Synthetic data

description: Synthetic data has become increasingly accessible due to remarkable advancements in machine learning. This data is extremely useful to researchers due to its wide range of applications. Synthetic data may be used to robust populations that are under-sampled, or to create permutations of some existing data, generating combinations not seen in the original data. Synthetic data may also be used in place of the original data completely when sensitive aspects limit the distribution.
description: Previously, research in synthetic data generation has been primarily focused on generating data that is maximally realistic. Significantly less attention has been paid to assurances of other components of the data, such as privacy concerns or data diversity. This has left a gap in the field of synthetic data generation. We address this through the investigation of multi-agent synthetic data generation.
description: In this dissertation, we expand the scope of data generation by introducing agents that optimize various facets of synthetic data, such as privacy, class diversity, and training utility. We propose a novel, multi-objective synthetic generation framework to allow all of these objectives to be optimized. We finally demonstrate this framework can generate high quality data across multiple domains for an arbitrary number of objectives.
“Confident Girls”: A Case-Study of the Self-Esteem of Pre-Adolescent Females in a Non-Traditional Educational Environment
Creators: name: Forster, Emma
Publisher: name: Brandeis University
Year: 2022
Subjects: self-esteem
confidence
educational environment
socioecological model
pre-adolescence
Sociology of Sex and Gender

description: This study uses a meaningful case study sample to investigate the self-esteem of pre-adolescent girls and the contributing factors. I studied three pre-adolescent girls in rural Hawaii who all participated in the same homeschooling community. In this paper, I offer a socioecological model of the perceived support of self-esteem of the girls. This model addresses the following questions: How do the three girls in the study demonstrate confidence? Are they perceived as confident by themselves, and the others in the study? What aspects of the educational community context are considered salient by educators, parents, and students? My findings draw on the following data sources: Informal observations over nine sessions and interviews with students, parents and teachers (N= 13). Following a thematic analysis, thirteen salient themes were identified which speak to different aspects of the educational context which are perceived to foster self-esteem. From an educational and psychological perspective, my findings emphasize the nested and interconnected influences within an educational environment that should be considered regarding self-esteem in pre-adolescent females.
The Cultural Coercion and Minimization of Gender “(Micro)aggressions”
Creators: name: Hansen-Osborne, Hailey
Publisher: name: Brandeis University
Year: 2023
Subjects: sexual violence
microaggressions
victim-survivors
socialization
gender-based violence
intersectionality
patriarchy
rape
sexual assault
consent
love
humor
Trauma

description: This study explores the connection between the minimization of (micro)aggressions and the propensity of American society to diminish the impact of “bigger,” more legally recognized, acts such as rape and sexual assault. One hundred and seventy-three participants ages eighteen to seventy were surveyed for an IRB-approved study that compared people’s experiences with their perpetuation of (micro)aggressions. This study argues that there is a cultural coercion to minimize (micro)aggressions, which creates a larger cultural environment that is infused with violence. (Micro)aggressions, in and of themselves, are violent and are an allowable mechanism of perpetuating gender-based violence on a day-to-day basis. The messages sent by media, such as Disney and romantic comedies, play an important role in shaping social scripts that people are pressured to adhere to. Further, this study explores how repeated exposure to (micro)aggressions and sexual violence in media impacts people’s sympathy for victim-survivors, beliefs about their severity, and the normalization of violence as a normal aspect of love. The use of humor as a mechanism of minimization is also explored. Lastly, this study argues that people, through socialization, learn to contribute and maintain the perpetuation of them, while justifying (micro)aggressions as minimal harmful, which then informs people’s baseline attitude about sexual violence. Overall, the daily minimization of (micro)aggressions helps foster a culture that functions on the belief that sexual violence is “not so bad.” 
Experimental and theoretical studies of unimolecular reactions of gas phase cluster ions.
Creators: name: Ochran, Richard Acquaah.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Chemistry, Physical.

description: The work presented in the following pages is the culmination of four years of research in the area of gas phase ion chemistry. During this period mass spectrometry and ab initio molecular orbital calculations were employed to investigate the unimolecular decomposition of proton-bound complexes between acetonitrile and methanol, ethanol, n-propanol, i-propanol, n-butanol, s-butanol, i-butanol, and t-butanol. Common to these systems, is a competition between dissociation of the hydrogen bond in the proton-bound dieter and isomerization to (CH3CNR)(H2O)+ (R=CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, butyl). The minimum energy reaction pathways for the isomerization in these systems are presented and compared. The dominant isomerization pathway for these ions is an internal SN2 reaction that proceeds via an intermediate CH3CN &cdots; ROH2+ ion (R=CH3, CH2CH 3, CH2CH2CH3, CH(CH3) 2). The mass spectra for the four butanol containing dimers (n-, s-, i-, and t-butanol) show similar behaviour. The effect of chlorine substitution on the acetonitrile on the four systems methanol, ethanol, n- and i-propanol were also investigated. The theoretical and experimental studies reveal a potential energy surface which is very similar to that obtained for the CH 3CN containing analogues (CH3CN)(CH3OH)H +, (CH3CN)(CH3CH2OH)H+, (CH3CN)(CH3CH2CH2OH)H+ and (CH3CN)((CH3)2CHOH)H +. The effect of chloro-substitution of the acetonitrile does not significantly affect the height of the rate limiting isomerization barrier which governs the water loss channel. The chloro-substitution however, lowers the proton affinity of the chloroacetonitrile and hence where there is competition between simple cleavage and isomerization, the protonated alcohol outcompetes the protonated chloroacetonitrile in the MI mass spectra. The dimer ion of acetonitrile and oxygen exhibit three peaks at m/z 32 (O 2), m/z 41, (CH3CN and ·CH2CNH +) and m/z 56 (-OH) in its MI mass spectrum. When O2 (triplet ground state) encounters a CH3CN+· or ·CH2CNH+ ion, the resulting complex (C2H3N)(O2)+· can take on either a doublet or quartet character. RRKM calculations predict a fast forward isomerization of CH3CN+· to ·CH2CNH+. The fact the dissociation and isomerization compete on the microsecond timescale is an indication that the reactions do not occur statistically and that RRKM theory does not apply.
title: Cartilage in facet joints of patients with ankylosing spondylitis (AS) shows signs of cartilage degeneration rather than chondrocyte hypertrophy
title: implications for joint remodeling in AS
titleType: Subtitle
Creators: name: Bleil, Janine
name: Sieper, Joachim
name: Maier, René
name: Schlichting, Uwe
name: Hempfing, Axel
name: Syrbe, Uta
name: Appel, Heiner
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Introduction In ankylosing spondylitis (AS), joint remodeling leading to joint ankylosis involves cartilage fusion. Here, we analyzed whether chondrocyte hypertrophy is involved in cartilage fusion and subsequent joint remodeling in AS. Methods We assessed the expression of chondrocyte hypertrophy markers runt-related transcription factor 2 (Runx2), type X collagen (COL10), matrix metalloproteinase 13 (MMP13), osteocalcin and beta-catenin and the expression of positive bone morphogenic proteins (BMPs) and negative regulators (dickkopf-1 (DKK-1)), sclerostin, (wingless inhibitory factor 1 (wif-1)) of chondrocyte hypertrophy in the cartilage of facet joints from patients with AS or osteoarthritis (OA) and from autopsy controls (CO) by immunohistochemistry. Sex determining region Y (SRY)-box 9 (Sox9) and type II collagen (COL2) expression was assessed as indicators of chondrocyte integrity and function. Results The percentage of hypertrophic chondrocytes expressing Runx2, COL10, MMP13, osteocalcin or beta-catenin was significantly increased in OA but not in AS joints compared to CO joints. Frequencies of sclerostin-positive and DKK-1-positive chondrocytes were similar in AS and CO. In contrast, wif-1- but also BMP-2- and BMP-7-expressing and Sox9-expressing chondrocytes were drastically reduced in AS joints compared to CO as well as OA joints whereas the percentage of COL2-expressing chondrocytes was significantly higher in AS joints compared to CO joints. Conclusions We found no evidence for chondrocyte hypertrophy within hyaline cartilage of AS joints even in the presence of reduced expression of the wnt inhibitor wif-1 suggesting that chondrocyte hypertrophy is not a predominant pathway involved in joint fusion and remodeling in AS. In contrast, the reduced expression of Sox9, BMP-2 and BMP-7 concomitantly with induced COL2 expression rather point to disturbed cartilage homeostasis promoting cartilage degeneration in AS.
Harmonizing community-based health worker programs for HIV: a narrative review and analytic framework
Creators: name: De Neve, Jan-Walter
name: Boudreaux, Chantelle
name: Gill, Roopan
name: Geldsetzer, Pascal
name: Vaikath, Maria
name: Bärnighausen, Till
name: Bossert, Thomas J
Publisher: name: BioMed Central
Year: 2018

description: Background: Many countries have created community-based health worker (CHW) programs for HIV. In most of these countries, several national and non-governmental initiatives have been implemented raising questions of how well these different approaches address the health problems and use health resources in a compatible way. While these questions have led to a general policy initiative to promote harmonization across programs, there is a need for countries to develop a more coherent and organized approach to CHW programs and to generate evidence about the most efficient and effective strategies to ensure their optimal, sustained performance. Methods: We conducted a narrative review of the existing published and gray literature on the harmonization of CHW programs. We searched for and noted evidence on definitions, models, and/or frameworks of harmonization; theoretical arguments or hypotheses about the effects of CHW program fragmentation; and empirical evidence. Based on this evidence, we defined harmonization, introduced three priority areas for harmonization, and identified a conceptual framework for analyzing harmonization of CHW programs that can be used to support their expanding role in HIV service delivery. We identified and described the major issues and relationships surrounding the harmonization of CHW programs, including key characteristics, facilitators, and barriers for each of the priority areas of harmonization, and used our analytic framework to map overarching findings. We apply this approach of CHW programs supporting HIV services across four countries in Southern Africa in a separate article. Results: There is a large number and immense diversity of CHW programs for HIV. This includes integration of HIV components into countries’ existing national programs along with the development of multiple, stand-alone CHW programs. We defined (i) coordination among stakeholders, (ii) integration into the broader health system, and (iii) assurance of a CHW program’s sustainability to be priority areas of harmonization. While harmonization is likely a complex political process, with in many cases incremental steps toward improvement, a wide range of facilitators are available to decision-makers. These can be categorized using an analytic framework assessing the (i) health issue, (ii) intervention itself, (iii) stakeholders, (iv) health system, and (v) broad context. Conclusions: There is a need to address fragmentation of CHW programs to advance and sustain CHW roles and responsibilities for HIV. This study provides a narrative review and analytic framework to understand the process by which harmonization of CHW programs might be achieved and to test the assumption that harmonization is needed to improve CHW performance.