cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Quantification of glucose uptake in the mammalian skeletal muscle
Creators: name: Rudayni, Hassan
Publisher: name: La Trobe
Year: 2023

description: Submission note: A thesis submitted in total fulfillment of the requirements for the Degree of Doctor of Philosophy to the School of Life Sciences, College of Science, Health and Engineering, La Trobe University, Bundoora.

Until now, the ability to measure accurately the kinetic properties of glucose uptake in muscle had meant that the limitations to glucose transport and thus, dysregulation of glucose transport, could only be speculated upon. This arose in part from the inability to discriminate between barriers (such as the surface membrane and hexokinase). It also arose because of the inability to directly measure the intracellular glucose concentration. The first aim of this thesis was to describe a new and novel approach to measure the transport kinetics of glucose in single muscle fibres of known type. In Chapters 2 and 3 I describe a novel method for measuring the kinetics of glucose transport specifically via the GLUTs. I consequently identify for the first time the kinetic properties of GLUTs in situ by fibre type and determine the contribution of GLUT-1 and GLUT-4 to basal glucose transport and that the total glucose pool is not fully utilized even at high extracellular glucose concentration. Consequently, I also show that the basal rate of transport of glucose across the surface membrane is not the rate limiting step. I also measure for the first time the intracellular glucose concentration and describe a possible role of elevated intracellular glucose in the development of insulin resistance. The second major aim of this thesis was to then examine the properties of Insulin mediated glucose transport using this newly developed technique. In Chapter 4, I describe the kinetic properties of insulin mediated glucose transport. I show that kinetic properties of insulin mediated glucose transport via GLUTs are identical for both FT and ST fibres. Importantly, I was able to measure the rate of hexokinase activity and show that insulin has no effect on hexokinase. Consequently, I show that the kinetics of insulin xxviii mediated glucose uptake is predominately mediated by GLUT-4 translocation to the surface membrane. The third major aim of this thesis was to examine the effects of specific reactive oxygen and nitrosylating species (ROS/NO) on the kinetics of glucose transport. I describe for the first time an effect of ROS/NO specifically on GLUT-1 and hexokinase and show that both molecular species contribute to increased glucose uptake via an AMPK independent pathway. These results have implications in understanding the role of ROS/NO in the development of insulin resistance.
Planning out of place and the place of planners: Culture, landscape and planning for farmland protection in an era of rural transition: a case study of peri-urban and multi-functional regions around Melbourne, Australia
Creators: name: Butt, Andrew
Publisher: name: La Trobe
Year: 2023

description: Submission note: A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Humanities and Social Sciences, College of Arts, Social Sciences and Commerce, La Trobe University, Bundoora.

Peri-urbanisation and related processes of development and change challenge the legitimacy and capacity of rural planning as an instrument for effectively managing land use. Trends towards non-farming rural activities and the emergence of social preferences for rural lifestyle options are evident in land use conflicts and are the central concerns of rural planning in Australia. Yet despite the variegated realities of change, planning responses are typically framed in abstract, uniform and delocalised ideals of appropriate rural landscapes and land uses. These regions defy existing logics of territorial distinction. My research explored the practices and attitudes of rural planners operating within a context of peri-urbanisation and the formation of multi-functional rural landscapes. It involved a case study of the views and responses of land use planners working within the extensive and expanding peri-urban region surrounding the city of Melbourne, in the Australian state of Victoria. Its substance is concerned with how peri-urbanisation is occurring, how policy and policy cultures have formed to problematise it, and consequently how planners consider, understand and represent the formation of such places. My work included historical assessment, land use and population analysis, policy texts and interviews with planners to consider the narratives of rural planning for farmland protection in this region. Finally, I investigated how planning is performed, negotiated and discussed in this region, specifically in relation to understandings of agriculture, including its perseverance and productivity in the face of community and economic change. This insight enables conclusions about the need to address the defusion of collective representations of the peri-urban. Despite planners preferences for a doctrinal understanding of rural land use, in an era of increasingly hybrid and multi-functional place formation approaches to planning and community governance require success in creating shared narratives of land use futures.
An Optimised High Current Impulse Source
Creators: name: Kempen, S.
name: Peier, D.
Publisher: name: Institut für Umformtechnik - Technische Universität Dortmund
Year: 2004
Subjects: subject: electromagnetic high-speed forming
subject: impulse current source
subject: optimisation
subject: 620
subject: 670

description: Starting from a predefined 8/20 µs impulse current, the design and construction of an impulse current source is derived. In the first step an equivalent circuit is defined that meets exactly the predefined impulse current. In the next step the components that are required to realise the equivalent circuit diagram are chosen and modelled by their equivalent circuit diagrams. As far as the components do not show ideal behaviour, the stray parameters if the components are determined by calculation and measurement. Further on, the construction parameters for the geometric structure of the plant are derived from the equivalent circuit diagram of the entire impulse generating network. Finally it is shown that the measured current of the realised impulse current generator meets exactly the desired predefined impulse current.
(200823) Henry Glaisyer
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The Distances of the Galactic Novae
Creators: name: Özdönmez, Aykut
name: Güver, Tolga
name: Cabrera-Lavers, Antonio
name: Ak, Tansel
Publisher: name: arXiv
Year: 2016
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Utilising the unique location of red clump giants on colour-magnitude diagrams obtained from various near-IR surveys, we derived specific reddening-distance relations towards 119 Galactic novae for which independent reddening measurements are available. Using the derived distance-extinction relation and the independent measurements of reddening we calculated the most likely distances for each system. We present the details of our distance measurement technique and the results of this analysis, which yielded the distances of 73 Galactic novae and allowed us to set lower limits on the distances of 46 systems. We also present the reddening-distance relations derived for each nova, which may be useful to analyze the different Galactic components present in the line of sight.
description: Published in MNRAS (24 pages, 12 figures, 4 tables), Minor typo correction. For the catalogue which has all reddening-distance relations, see http://highenergyastro.istanbul.edu.tr/novae_cat/index.php, 2016MNRAS.461.1177O
Synthesis of novel hybrids of 1,2,3-triazoles-hydrazone: targeting cholinesterases and Alzheimer's related genes
Creators: name: Shareghi-Boroujeni, Diba
name: Iraji, Aida
name: Dara, Mahintaj
name: Hashempur, Mohammad Hashem
name: Zare, Shahrokh
name: Hariri, Roshanak
name: Akbarzadeh, Tahmineh
name: Saeedi, Mina
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Cell Biology
Neuroscience
Pharmacology
Chemical Sciences not elsewhere classified

description: Aim: A new series of 1,2,3-triazole-hydrazone derivatives were developed to evaluate their anti-Alzheimer's activity. Materials & methods: All compounds were screened toward cholinesterases via the modified Ellman's method. The toxicity assay on SH-SY5Y cells was performed using the MTT assay, and the expression levels of GSK-3α, GSK-3β, DYRK1 and CDK5 were assessed in the presence of compounds 6m and 6p. Results:6m and 6p; acting as mixed-type inhibitors, exhibited promising acetylcholinesterase and butyrylcholinesterase inhibitory activity, respectively. 6m demonstrated no toxicity under tested concentrations on the SH-SY5Y cells and positively impacted neurodegenerative pathways. Notably, 6m displayed a significant downregulation in mRNA levels of GSK-3α, GSK-3β and CDK5. Conclusion: The target compounds could be considered in developing anti-Alzheimer's disease agents. A new series of 1,2,3-triazole-hydrazone hybrids were synthesized and evaluated for their anti- Alzheimer's activity. Synthesized compounds were screened for cholinesterase inhibitory activity to select potent compounds for further biological assessment. Compounds 6m and 6p exhibited promising inhibitory activity, with IC50 values of 5.23 and 3.39 μM against AChE and BChE, respectively, as mixed-type inhibitors. Compounds 6m demonstrated no toxicity under tested concentrations on the SH-SY5Y cell line and positively impacted neurodegenerative pathways. Compound 6m displayed a significant downregulation in mRNA levels of GSK-3α, GSK-3β and CDK5, suggesting a potential indirect role in mitigating toxic neurofibrillary tangle and amyloid β (Aβ) aggregate formation.
The Indonesian Foreign Fighters, Hegemonic Masculinity and Globalisation
Creators: name: NOOR HUDA ISMAIL
Publisher: name: Monash University
Year: 2019
Subjects: subject: 160607 International Relations
subject: FOS: Political science
subject: Gender studies

description: The thesis investigated the role of gender in giving the rise of Indonesian Muslim foreign fighters’ networks. It finds that promoting and socialising a specific understanding of masculinity—especially the notion of being a mujahid—as the highest social status for Muslim men, plays a much more important role relative to other factors such as (globalised) religious ideology, impact of state ideology, securitisation and even poverty, to providing an environment conducive for the rise of foreign fighters in Indonesia.
Quantum Heat Current under Non-perturbative and Non-Markovian Conditions: Applications to Heat Machines
Creators: name: Kato, Akihito
name: Tanimura, Yoshitaka
Publisher: name: arXiv
Year: 2016
Subjects: subject: Quantum Physics (quant-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We consider a quantum system strongly coupled to multiple heat baths at different temperatures. Quantum heat transport phenomena in this system are investigated using two definitions of the heat current, one in terms of the system energy, and the other in terms of the bath energy. When we consider correlations among system-bath interactions (CASBI) -- which have a purely quantum mechanical origin -- the definition in terms of the bath energy becomes different. We found that CASBI are necessary to maintain the consistency of the heat current with thermodynamic laws in the case of strong system-bath coupling. However, within the context of the quantum master equation approach, both of these definitions are identical. Through a numerical investigation, we demonstrate this point for a non-equilibrium spin-boson model and a three-level heat engine model using the reduced hierarchal equations of motion approach under strongly coupled and non-Markovian conditions. We observe cyclic behavior of the heat currents and the work performed by the heat engine,and we find that their phases depend on the system-bath coupling strength. Through consideration of the bath heat current, we show that the efficiency of the heat engine decreases as the strength of the system-bath coupling increases, due to the CASBI contribution. In the case of a large system-bath coupling, the efficiency increases further if the bath temperature is decreased, with fixed the ratio of the bath temperatures, due to the discretized nature of energy eigenstates. This is also considered to be a unique feature of quantum heat engines.
description: 10 pages, 6 figures, updated in the published version
“To You it’s Just Words”: David Foster Wallace’s Fiction and Affect Theory
Creators: name: AISLING NANDINI SMITH
Publisher: name: Monash University
Year: 2019
Subjects: subject: Literature
subject: 200506 North American Literature
subject: FOS: Languages and literature

description: Affect is an underlying thread in David Foster Wallace studies; discussions of sincerity, irony and empathy implicitly assume that affect exists in Wallace’s writing as a key concern. However, affect itself has remained largely untheorised, with critics usually dissolving explorations of affect into these frameworks. In contrast, this thesis sets out to explore Wallace’s fiction through the lens of affect theory. Rather than discussing affect in a general way, it focuses on specific affects. Each of the chapters traces an individual affect across one of Wallace’s fictional works.
Marital experiences of young married couples in Vietnam
Creators: name: Vu, Thanh Thi
Publisher: name: La Trobe
Year: 2023

description: Submission note: A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Humanities and Social Sciences College of Arts, Social Sciences and Commerce La Trobe University Bundoora".

This thesis investigates the meaning and practice of marriage among young couples living in Vietnam. The exposure to foreign cultures in the context of strengthening socio-cultural exchanges has led to concerns about the risks to the longevity and harmony of marriage that will accompany the de-traditionalisation and/or modernisation of marriage in Vietnam. Marriage in Vietnam is also said to be challenged by gender inequality arising from the influences of patriarchal values of Confucianism. By conducting in-depth interview with 30 young couples, the thesis explores the meaning of marriage and the construction of gender relationships including experiences of gender equality between 30 young Vietnamese married couples. The thesis argues that marriage remains important. While marriage is sometimes thought to be in decline in the West, the data suggest that young people in Vietnam today remain committed to marriage, which retains both symbolic and practical significance for individuals. The perceptions and expectations of young people reflect the continuing influence of Vietnamese norms that emphasise marriage as essential and the value of harmonious and enduring marital relationships. I also investigate the construction of gender relations between spouses. There are dilemmas reflected in the marriages of the young couples as they try to sustain and maintain enduring and harmonious marriages, while also wanting to fulfil some of the ideals of love, mutual disclosure and an egalitarian relationship. There remains a clear imbalance in their relationships, with wives more involved in managing chores, money, affection and conflict than men. However, the spousal relationships of young couples demonstrate an egalitarian ethos in the way they emphasise love and seek to share responsibilities in their marriage.
Hyperscaling violating black hole solutions and Magneto-thermoelectric DC conductivities in holography
Creators: name: Ge, Xian-Hui
name: Tian, Yu
name: Wu, Shang-Yu
name: Wu, Shao-Feng
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We derive new black hole solutions in Einstein-Maxwell-Axion-Dilaton theory with a hyperscaling violation exponent. We then examine the corresponding anomalous transport exhibited by cuprate strange metals in the normal phase of high-temperature superconductors via gauge/gravity duality. Linear temperature dependence resistivity and quadratic temperature dependence inverse Hall angle can be achieved. In the high temperature regime, the heat conductivity and Hall Lorenz ratio are proportional to the temperature. The Nernst signal first increases as temperature goes up but it then decreases with increasing temperature in the high temperature regime.
description: 10 pages, two figures, major revision, published version
Fachdidaktisches Wissen von Lehrerinnen und Lehrern bei der didaktischen Strukturierung von Mathematikunterricht im Vergleich mit COACTIV-Testergebnissen
Creators: name: Hille, Manuela
Publisher: name: Gesellschaft für Didaktik der Mathematik
Year: 2012
Subjects: subject: 510

description: In der COACTIV-Studie wurde unter anderem das fachdidaktische Wissen mithilfe eines Tests erhoben, der jedoch keine Einschätzung des tatsächlichen Unterrichts der Lehrkräfte erlaubt. Im Vortrag werden anhand von Analysen einer kleinen qualitativen Videostudie die didaktischen Strukturierungen des Unterrichts dreier Lehrpersonen vorgestellt. Diese haben ebenfalls den COACTIV-Test bearbeitet, sodass ein Vergleich der COACTIV-Testergebnisse mit dem tatsächlichen Unterricht möglich wird.
Development of a Quantitative MRM assay using Sebum to Diagnose Parkinson's Disease
Creators: name: Zhu, Minhui
name: van Dissel, Lea
name: Russell, Matthew
name: Walton-Doyle, Caitlin
name: Hoare, Thomas
name: Sinclair, Eleanor
name: Trivedi, Drupad
name: Hollywood, Katherine
name: Rijs, Anouk
name: Welch, Jessica
name: Hu, Michele
name: Barran, Perdita
Publisher: name: Zenodo
Year: 2024

description: Talk at the British Mass Spectrometry Society (BMSS) Super Meeting 2024 in Warwick
Olson J. R01 HD082554-01A1. The Impact of Early Medical Treatment in Transgender Youth. 2014
Creators: name: Regenstreif, Leonora
Publisher: name: figshare
Year: 2023
Subjects: Child and adolescent development

description: Summary of Olson CHLA Grant Proposal:
 According to the study authors the objective of the research is "to provide evidence-based data to inform clinical care for transgender youth". There are two cohorts proposed to be studied. 1) An early pubertal cohort (Tanner Stages 2-3) to be evaluated for the effects of "GnRH agonists administered for puberty suppression, on mental health, psychological well-being, physiologic parameters, and bone health", and 2) A later pubertal cohort (Tanner stages 4-5) evaluated for the effects of "cross-sex hormones administered for gender transition on mental health, psychological well-being, and metabolic/physiologic parameters as well as document the safety of cross-sex hormones.
"Mainlander" as an Evolving Identity: A Study of Eight Works by Taiwan's Second-generation Mainlander Writers
Creators: name: YU-TING HUANG
Publisher: name: Monash University
Year: 2019
Subjects: Literature

description: This thesis examines the “mainlander" identity articulated in eight literary works published in Taiwan from 1982 to 2011 by second-generation mainlander writers, whose parents are Chinese civil war migrants. Drawing upon theories of Sinophone studies and memory studies, it argues that while these works are focused on the themes of “China” and “Chineseness”, mainlander characters are presented as profoundly informed by their life in Taiwan and unable to settle into a “Chinese” or “Taiwanese” identity. It argues that the “mainlander" identity in these texts is distinguished by its cultural hybridity and emotional in-betweenness, which contests the existing homogeneous idea of “Chineseness”.
(200824) Joseph Glaisyer
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Foucault und Mathematikdidaktik
title: eine fruchtbare Mischung?
titleType: AlternativeTitle
Creators: name: Kollosche, David
Publisher: name: Gesellschaft für Didaktik der Mathematik
Year: 2012
Subjects: subject: 510

description: Bisher blieb das Werk von Michel Foucault in der deutschen Mathematikdidaktik weitestgehend ungenutzt. Vorgestellt werden soll daher ein foucaultsches Theorieangebot rund um sein Konzept der Gouvernementalität, in welchem sich Macht, Wissen und Individualisierung erklärungsstark verbinden. In der Hoffnung, den Nutzen der Arbeit Foucaults für die Mathematikdidaktik diskutieren zu können, sollen abschließend Fragen an den Mathematikunterricht in den Begriffen Foucaults gestellt werden.
The construction of the figure of the ‘Un-Australian’ in Australian newspaper coverage of two natural disasters
Creators: name: Briggs, James
Publisher: name: La Trobe
Year: 2023

description: Submission note: A thesis submitted in total fulfilment of the requirements for the degree of Master of Arts to the School of Humanities and Social Sciences, College of Arts, Social Sciences and Commerce, La Trobe University, Bundoora.

This thesis seeks to answer the research question of what kinds of values have been constructed as ‘un-Australian’ in newspaper coverage of natural disasters, and determine how these values fit in with historical media-constructed representations of ‘Australian’ qualities. A literature review, of historical Australian texts, was conducted to ascertain some of the values that have been historically discussed as ‘Australian’. Following this, discourse analysis was applied across a sample of 36 newspaper articles in order to ascertain the sorts of values that are being constructed, by the media, as ‘Australian’ during times of national crisis. The research discovered that modern constructions of ‘Australian’ values are both dynamic and contested, with the findings indicating that, in contrast to the egalitarian values historically constructed as ‘Australian’, neo-liberal values such as self-reliance and sufficiency are often discussed by newspapers as ‘Australian’ during times of national crisis. The crucial discovery of this research is that during contemporary newspaper coverage of natural disasters ‘Australian’ values are often assigned and constructed in the negative, through in- depth descriptions of the values seen as ‘un-Australian’.
title: Sichtweisen von Lernenden zu statistischer Variabilität
title: Vorstellungen von Grundschüler(inne)n, Realschüler(inne)n und Studierenden
titleType: AlternativeTitle
Creators: name: Kuntze, Sebastian
Publisher: name: Gesellschaft für Didaktik der Mathematik
Year: 2012
Subjects: subject: 510

description: Mit statistischer Variabilität umgehen zu können ist ein wesentlicher Aspekt von Statistical Literacy. Hierbei könnten jenseits der Kompetenzmessung Überzeugungen und Sichtweisen von Lernenden zu statistischer Variabilität eine wesentliche Rolle spielen. In dieser quantitativ angelegten Studie wurde daher untersucht, welche Sichtweisen Lernende verschiedener Altersstufen in diesem Bereich haben.
Prospects of detecting CEvNS using XENON100
Creators: name: Ni, Kaixuan
Publisher: name: Zenodo
Year: 2019
Subjects: CEvNS
dark matter
neutrinos

description: Two-phase xenon detectors are being actively developed over the last decade and made substantial improvement of search sensitivity for WIMP dark matter. These detectors, operated in time projection chamber (TPC) mode, strongly suppress the electronic recoil background, making it possible to detect CEvNS of neutrinos at the Spallation Neutron Source (SNS). In addition, two-phase xenon detectors operated in electron counting (EC) mode are sensitive to single-electron signals, making it possible to detect CEvNS from reactor neutrinos and Solar neutrinos. Drawing experience from the XENON10, XENON100 and recent XENON1T experiments, we will discuss the prospects of detecting coherent scattering of neutrinos from SNS, reactors and the Sun using an improved and movable XENON100 detector. Presented at the 2019 Magnificent CEvNS workshop.
Current and projected changes in the southern hemisphere UTLS ozone and effects of bushfire smoke aerosols
Creators: name: Siddaway, Jason Michael
Publisher: name: La Trobe
Year: 2023

description: Submission note: A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Molecular Science, College of Science, Health and Engineering, La Trobe University, Bundoora.

An analysis of future projections of ozone levels over Antarctica from coupled chemistry climate models (CCMVal-2) using multi-model median (MMM) trends found that the Antarctic Total Ozone Column (TOC) will not return to 1965 values during the September-November months by the end of the 21st century and that December TOC will not return to that baseline until 2080. The rate of TOC recovery during December was slower than for austral spring, due to a delayed increase of ozone at 50-100 hPa. At these altitudes, MMM temperature trends were projected to stop increasing by 2060 due to the combined radiative effect of a projected increase in greenhouse gases (GHG) and a decrease in ozone depleting substances. A persisting polar vortex was projected until the middle of the 21st century during December in the lower stratosphere. Seasonal TOC zonal asymmetry patterns are analysed, with MMM seasonal trends during the observation period (1979-2005) showing reduced amplitudes and smaller eastward phase trends in TOC compared with satellite observations during austral spring. Fourier decomposition of MMM TOC trends show that the QSW-wave 1 harmonic is dominant during austral spring at Antarctic latitudes, indicating reduced tropospheric planetary wave forcing. There is qualitative agreement between eastward phase trends over Antarctica and model simulations during the ozone depletion period which then reverses with increasing ozone during the 21st century. A residual eastward phase trend towards the end of the century in both seasons is observed, suggesting a long-term phase shift in TOC distribution due to changes in GHGs and ozone depletion. Limb-scattered radiance data was used to monitor the pyrocb event from the 2009 Black Saturday bushfire as it was transported into the lower stratosphere, reaching altitudes of at least 21 km. The smoke plume dispersed over time and circled the globe in about 6 weeks, with smoke aerosols present in the lower stratosphere for approximately 3 months. Water vapour was entrained with the smoke plume from the upper troposphere, hydrating the dry lower stratosphere over latitudes of approximately 10-40◦S. Water vapour perturbations were observed for at least 3 weeks after bushfire ignition from two sets of satellite measurements. Additionally, the smoke plume also transported ozone-poor air from the troposphere into the lower stratosphere, providing localised ozone depletion for at least 4 weeks up to the lower boundary of the Brewer Dobson Circulation. Such chemical perturbations have not been observed previously in relation to a pyrocb event.
Informationsvermittler zwischen Schreiben und Lesen: Wissensmanager, Bibliothekarinnen oder wer oder was?
Creators: name: Havekost, Hermann
Publisher: name: Universität Dortmund
Year: 2002
Subjects: subject: 020

description: Seit dem Aufkommen von CD-ROM und Internet wird das Ende von Buch, Bibliothek und bibliothekarischen Aufgaben prognostiziert. Bibliothekarische Bedenkenträger, die sich diese Prognosen zu eigen gemacht haben, denken darüber nach, was sie dann tun sollen und wie man die Bibliothek retten kann, wenn sie es denn nötig hat. Ich denke, sie stellen einfach noch die falschen Fragen. Man muß die Bibliotheken gar nicht retten wollen. Wenn die Bibliothekare die richtigen Fragen stellen würden, dann könnten sich auch andere, vielleicht neue Perspektiven zeigen, auch für Bibliotheken. Darüber sollte man sprechen.
Crucible of Dreams: Gallipoli as Myth in the Performance of Australian National Identity
Creators: name: STEPHEN WILLIAM VIZARD
Publisher: name: Monash University
Year: 2020
Subjects: subject: 190402 Creative Writing (incl. Playwriting)
subject: FOS: Arts (arts, history of arts, performing arts, music)
subject: 160403 Social and Cultural Geography
subject: FOS: Social and economic geography
subject: Sociology
subject: FOS: Sociology
subject: 160601 Australian Government and Politics
subject: FOS: Political science
subject: 160609 Political Theory and Political Philosophy
subject: History
subject: 200502 Australian Literature (excl. Aboriginal and Torres Strait Islander Literature)
subject: FOS: Languages and literature

description: The Centenary of Gallipoli in 2015, affirmed Gallipoli as the pre-eminent narrative in the performance of Australian national identity. Whilst a substantial body of research has examined Gallipoli in various modes of cultural discourse, mainly as history, little research has analysed its performance as myth. This study argues that the special status in Australia of Gallipoli and its embodied Anzac Spirit, can be understood in its performance as a myth, in particular as Australia’s national foundation myth. The research demonstrates an original methodology and arguments of relevance to the study of nation, national myths, cultural studies, history, Australian studies and Performance Theory.
(200825) Ellen Glaisyer
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Die Bibliothek als Verleger elektronischer Publikationen - eine juristische Checkliste
Creators: name: Müller, Harald
Publisher: name: Universität Dortmund
Year: 2002
Subjects: subject: 020

description: Der Vortrag schließt sich nahtlos an den Vortrag "Die Bibliothek als Verlag? - Rechtsfragen elektronischer Veröffentlichungen", gehalten am 24.11.1998 auf der Tagung "Neue Organisationsformen elektronischer Veröffentlichungen" in Dortmund (http://eldorado.uni-dortmund.de:8080/bib/98/workshop/mueller). Im Verlauf der dortigen Diskussion hatte sich gezeigt, daß ein praktisches Bedürfnis für Bibliotheken besteht, die im Zusammenhang mit elektronischen Veröffentlichungen auftretenden Rechtsfragen, besonders das Vertragsverhältnis mit dem Verfasser eines digitalen Werks, anhand einer Checkliste durchgehen zu können. Der Vortrag wird sich deshalb darauf beschränken, die wichtigsten Gesichtspunkte einer vertraglichen Vereinbarung zwischen Bibliothek und Autor darzustellen und juristisch zu kommentieren. Die Webseiten vieler deutscher Bibliotheken bieten bereits vorzügliche Beispiele gelungener Verträge. In einer Synthese werden die besten Formulierungen bzw. Regelungen zu einer Art Mustervertrag zusammengestellt werden.
Designing an optimal fed-batch process using a comprehensive differential equation model
Creators: name: Schlögel, Guido
Year: 2023
Subjects: subject: Bioinformatik
subject: Bioinformatics
subject: FOS: Computer and information sciences
subject: ÖFOS 2012 -- NATURWISSENSCHAFTEN (1) -- Biologie (106) -- Biologie (1060) -- Bioinformatik (106005)
subject: ÖFOS 2012 -- NATURAL SCIENCES (1) -- Biology (106) -- Biology (1060) -- Bioinformatics (106005)
subject: fed batch
subject: differential equation model
subject: model simplification
subject: optimal control

description: Conference Poster
Crime and Court Reporting: Journalistic Autonomy in Australia, Hong Kong and Mainland China – A Comparative Study
Creators: name: YANZHU XU
Publisher: name: Monash University
Year: 2019
Subjects: subject: 200104 Media Studies
subject: FOS: Media and communications

description: This thesis investigates the status of journalistic autonomy, specifically crime and court reporting, and the influence of other social fields on this autonomy in Australia, Hong Kong and mainland China. By examining newspaper coverage and interviewing 18 journalists from the three regions, the study finds and argues that, for crime and court reporting, in Australia the biggest challenge is increasing market pressure; in mainland China the autonomy of journalism is weak under the influence of the powerful political regime; and in Hong Kong, crime and court reporting has been affected by the growing conflicts within the political arena.
“Calm down, it’s just Facebook”: Transparent, Responsive, and Interactive Facebook Audience Engagement in Australian Journalism
Creators: name: ERIN MAREE BRADSHAW
Publisher: name: Monash University
Year: 2019
Subjects: subject: 200104 Media Studies
subject: FOS: Media and communications

description: This project examined how four Australian news organisations engage with their audiences on Facebook both during routine daily coverage and at times of ethical controversy. It combined analysis of their posts with interviews and online surveys, adding depth and scope to the analysis. A key finding was that when news sites were unresponsive to public outcry over breaches in journalism ethics, the public would allow their comments to bleed into unrelated stories across the organisation’s Facebook page. This is the first time this kind of audience behaviour has been observed and documented in Journalism Studies research.
The role and regulation of the BH3‐only protein Bim in immune suppression during sepsis
Creators: name: Doerflinger, Marcel
Publisher: name: La Trobe
Year: 2023

description: Submission note: A thesis submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the Department of Biochemistry and Genetics, Institute for Molecular Science, College of Science, Health and Engineering, La Trobe University, Bundoora.

Sepsis is a complex inflammatory disorder that leads to substantial mortality in non‐coronary ICUs. Sepsis incidence after surgery trebled in the last 10 years and are estimated to further increase due to an aging population and comorbidities. Improved protocols for the treatment of acute sepsis have resulted in most patients surviving the early hyper‐inflammatory stage and entering a protracted immune suppressive phase, which accounts for most of the fatalities. This phase is characterized by extensive apoptosis in the cells of the adaptive immune system leading to prolonged lymphocytopenia. This makes the patients susceptible to nosocomial infections and is now considered an independent predictor of patient survival in sepsis. Independent reports suggested systemic circulating immunomodulatory factors in sepsis patients that mediate cellular apoptosis and immune suppression. The BH3‐only protein Bim was previously shown to be a major player in sepsis‐mediated immune cell apoptosis, however the molecular mechanisms remain elusive. In the present study, a central role for Bim during sepsis was confirmed both in vivo and in a newly established in vitro sepsis model assay system. The induction of endoplasmic reticulum stress was discovered to be the prevalent mechanism of Bim induction and blockage of ER stress led to improved lymphocyte survival. Biochemical purification identified a secreted form of the ER chaperone BiP/Grp78 as the apoptosis‐inducing factor. BiP was previously described to have immunomodulatory functions and therefore presents an exciting novel therapeutic target for sepsis. In the present study, monoclonal antibodies against recombinant human BiP were generated and validated in vitro as therapeutic tool for treatment of sepsis‐associated lymphocytopenia. Furthermore, a diagnostic ELISA was established and could show elevated levels of secreted BiP in septic mice and human sepsis patients and therefore BiP has the potential to be used as novel sepsis biomarker.
(200822) Acton Plummer
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Amtliche Mitteilungen der Universität Dortmund Nr. 03/82
Creators: name: (:Unkn) Unknown
Publisher: name: Universität Dortmund
Year: 1982
Subjects: subject: 080

description: 1. Promotionsordnung der Universität Dortmund für die Abteilung Bauwesen
description: 2. Diplomprüfungsordnung der Abteilung Chemie (Berichtigung der AM Nr. 8/79 und Nr. 9/80)
description: Amtliche Mitteilungen der Universität Dortmund ; 3, 1982
From Federation to the '501s': Māori inclusion and exclusion in Australia since 1901
Creators: name: PAUL ALLAN HAMER
Publisher: name: Monash University
Year: 2020
Subjects: History

description: Māori were largely included in White Australia, partly on the unwritten understanding that few would migrate. By the 1980s, however, trans-Tasman migration had become uneven, with significant flows of New Zealanders to Australia. This included many Māori and Pacific Islanders. Canberra became dissatisfied about this and instituted a series of migration filters. The most drastic of these has effectively excluded most New Zealanders in Australia from a social security safety net or pathway to citizenship. But while Māori have been those worst affected by these changes, Australia has continued to offer most Māori a significant increase in their material wellbeing.
Amtliche Mitteilungen der Universität Dortmund Nr. 18/85
Creators: name: (:Unkn) Unknown
Publisher: name: Universität Dortmund
Year: 1985
Subjects: subject: 080

description: Ordnung zur Änderung des Innenorganisationsrechts der Studentenschaft der Universität Dortmund vom 18. Dezember 1985
description: Amtliche Mitteilungen der Universität Dortmund ; 18, 1985
Motherlands: Interpreting Home Through the Gaze of the Flâneuse
Creators: name: AMARYLLIS MARIA PIA GACIOPPO
Publisher: name: Monash University
Year: 2019
Subjects: subject: 200599 Literary Studies not elsewhere classified
subject: FOS: Languages and literature
subject: 190402 Creative Writing (incl. Playwriting)
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: This thesis investigates flâneuserie as a mode of inquiry into the concept of home. Using both critical analysis and a creative inquiry, this research aims to define a methodology for flâneuserie using contemporary literary case studies. The critical component is centred on a literary analysis of nonfiction walking narratives by women writers: Valeria Luiselli’s Sidewalks (2014), Vivian Gornick’s The Odd Woman and the City (2015), and Igiaba Scego’s Roma Negata (2014). Applying flâneuserie to creative practice, the creative component features a series of experimental essays that follow my walks through the urban landscapes of my maternal heritage.
Nobiletin protects against alcohol-induced mitochondrial dysfunction and liver injury by regulating the hepatic NRF1-TFAM signaling pathway
Creators: name: Lu, Dan
name: Huang, Aiping
name: Tong, Xiaoqing
name: Zhang, Xiaoyan
name: Li, Songtao
name: Yu, Xiaolong
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine

description: Alcohol and its metabolites, such as acetaldehyde, induced hepatic mitochondrial dysfunction play a pathological role in the development of alcohol-related liver disease (ALD). In this study, we investigated the potential of nobiletin (NOB), a polymethoxylated flavone, to counter alcohol-induced mitochondrial dysfunction and liver injury. Our findings demonstrate that NOB administration markedly attenuated alcohol-induced hepatic steatosis, endoplasmic reticulum stress, inflammation, and tissue damage in mice. NOB reversed hepatic mitochondrial dysfunction and oxidative stress in both alcohol-fed mice and acetaldehyde-treated hepatocytes. Mechanistically, NOB restored the reduction of hepatic mitochondrial transcription factor A (TFAM) at both mRNA and protein levels. Notably, the protective effects of NOB against acetaldehyde-induced mitochondrial dysfunction and cell death were abolished in hepatocytes lacking Tfam. Furthermore, NOB administration reinstated the levels of hepatocellular NRF1, a key transcriptional regulator of TFAM, which were decreased by alcohol and acetaldehyde exposure. Consistent with these findings, hepatocyte-specific overexpression of Nrf1 protected against alcohol-induced hepatic Tfam reduction, mitochondrial dysfunction, oxidative stress, and liver injury. Our study elucidates the involvement of the NRF1-TFAM signaling pathway in the protective mechanism of NOB against chronic-plus-binge alcohol consumption-induced mitochondrial dysfunction and liver injury, suggesting NOB supplementation as a potential therapeutic strategy for ALD.
The dynamic characterisation of forgery behaviour and its application to static forensic examinations of disputed signatures
Creators: name: Dewhurst, Tahnee Ngair
Publisher: name: La Trobe
Year: 2023

description: Submission note: A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy by published work to the Department of Human Biosciences, Faculty of Health Sciences, La Trobe University, Bundoora.

One of the major tasks of Forensic Document Examiners (FDEs) in handwriting and signature examination casework is to compare a population of known signatures with questioned signatures, of which the authenticity is in dispute. Questioned signatures may be genuine (written by the known writer), disguised (written by the known writer for the purposes of denial) or simulated (forged by a writer other than the known writer). The opinions of FDEs, regarding the authenticity of these types of questioned signatures have been accepted in the judicial environment for well over a century, however, aspects of the skills claimed by FDEs and components of signature forgery theory remain un-tested, and have received both academic and judicial criticism. The body of work described here focused on: validating elements of forensic handwriting examination methodology; assessing motivational aspects of expertise testing regimes; and characterising signature dynamics associated with forgery behaviour. The results provided further empirical evidence that FDEs have a greater skill for signature examination tasks than lay individuals. The results also provided evidence regarding the types of signature formations that examiners should feel confident expressing authorship opinions on. However, it was also shown that there may be skilled forgeries that are not detected by some qualified forensic handwriting examiners and that examiners should exercise caution when viewing historically typical forgery indicators such as pen lifts in isolation. Furthermore, through the application of technology to assess above page writing instrument movements, it was shown how the implementation of advanced methodologies to detect and characterise covert features of forgery behaviour could be useful. It is concluded that the addition of objective methods of signature examination in support of FDEs’ current subjective approach, would provide a more scientifically robust platform for their investigations and subsequent forming of opinion as to the authenticity of signature formations.

Thesis with publications.
Paving the way to legitimacy in insurgency: the process of 'legitimation' and government response to FARC in Colombia
Creators: name: ALEXANDRA RACHEL PHELAN
Publisher: name: Monash University
Year: 2019
Subjects: subject: 160607 International Relations
subject: FOS: Political science

description: This thesis examines why the Colombian government alternated between military approaches and negotiations with the Revolutionary Armed Forces of Colombia (FARC). It found that legitimation activities influenced government response towards FARC in alternating between policies that emphasise a military or negotiation approach, and can shed light on why this is the case despite the shift in zero-sum and positive-sum considerations of legitimacy. This study argues that insurgencies deliberately use legitimation modes to cultivate organisational legitimacy and to construct an identity distinct from the subject of its grievances in an attempt to consolidate authority through the establishment of a normative system, in turn mobilising popular support. These legitimation modes shape insurgent strategy which impacts and influences government response.
(200821) Martha Plummer
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Moral Enhancement and Autonomy
Creators: name: PEI-HUA HUANG
Publisher: name: Monash University
Year: 2019
Subjects: subject: Philosophy
subject: FOS: Philosophy, ethics and religion

description: This thesis uses autonomy as the key notion to structure the inquiry of four major arguments against moral bioenhancement. I argue that using autonomy to approach these arguments helps clarify that the concerns behind these four arguments are all linked to two vital conceptions of autonomy: personal autonomy and political autonomy.