cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Treatment program effect and nursing patient classification as determinants of psychiatric nurse staffing
Creators: name: Evans, Dale Helen Frost
Publisher: name: University of Utah
Year: 2012
Subjects: Manpower

description: The influence of treatment programs of specialized psychiatric units of the need for nurse staffing was the problem area explored in this study.  The major research question asked whether the treatment program of an inpatient psychiatric unit accounted for more variance in the need for nurse staffing than was attributable to a nursing patient classification system which measures patients' need for nursing care.  The study was an extension of a larger research project completed for the Veterans Administration (VA).  Six test hospitals in the VA system were used as the sample.  The six test hospitals contained 30 impatient units with a variety of treatment programs.  A nursing patient classification instrument developed as an outcome of the VA study was used to reclassify all 898 original study patients according to their need for nursing care.  The direct care hours given to each category of patient were obtained by worksampling in the original study.  The direct care hours were used to analyze the effect of treatment program in hierarchical regression analysis.  The treatment program accounted for approximately 1% of the variance in direct care give to patients.  The nursing patient classification instrument together with shift accounted for 17% of the variance in direct care.  This finding was consistent with the original VA study in that other variable thought to influence the need for nurse staffing, such as amount of socialization groups or chronicity of patients, contributed 1% less to the variance in direct care.  The nursing patient classification instrument is a valid indicator of the amount of nursing care required by patients in a wide variety of VA hospitals.  A valid nursing patient classification instrument is particularly useful in determining staffing patterns and budget.  Other applications of the data produced by a nursing patient classification instrument are in the areas of quality assurance and costing of nursing care services.  With the advent of prospective payment systems for hospitals, it is crucial to the nursings' professional and economic survival to unbundle the costs of patients for nursing care from the daily hospital room rate.  The outcomes of the VA study and this study will add to the knowledge base of the profession in the area of nursing patient classification and support the use of new nursing patient classification system, the MESA Psychiatric Patient Classification System (MEPP).
Cyclocephala perforata Arrow 1913
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala perforata

description: Cyclocephala perforata Arrow, 1913
Cyclocephala perforata Arrow 1913a: 465 (Brazil)
Distribution. Suriname: MHCN - NEW COUNTRY RECORD (Suriname, Para, 1 km W of Zanderij, (5°27′37″N, 55°13′21″W). 5-I-2011. A. J. Hielkema. On UV/HPL in savanna forest.). French Guiana: Endrödi 1966a: 281, 1985a: 42, 118; Dechambre 1979c: 165; Brûlé et al. 2011b: 120; Duranton 2011: 14; Ponchel 2011: 60; Dupuis 2016b: 109; Moore et al. 2018b: 230. Brazil: Arrow 1913a: 465, 1937b: 14; Blackwelder 1944: 252; Endrödi 1966a: 281, 1985a: 42, 118; Dechambre 1979c: 165; Moore et al. 2018b: 230.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 177, DOI: 10.5281/zenodo.3678492
Palliative/end-of-life care in the newborn intensive care unit
Creators: name: Clark, Fawn N.
Publisher: name: University of Utah
Year: 2012
Subjects: Protocols
Newborn Intensive Care Units

description: This descriptive study determined the presence of palliative/end-of-life care protocols in two newborn intensive care units (NICUs). The study also explored the experiences and attitudes of NICU registered nurses (RNs) and neonatal nurse practitioners (NNPs) in providing care to infants at the end of life. This study served as a basis for exploring the current practices and attitudes of RNs and NNPs about neonatal end-of-life care. There was an absence of palliative/end-of-life care protocols in both NICUs in this study. The majority of respondents indicated that they thought the addition of a neonatal palliative/end-of-life care protocol would be helpful to them in providing care to infants and their families. Several common themes regarding RN and NNP perceptions of skills, concerns, and rewards in providing neonatal palliative/end-of-life care were found.
Brief an [Johann Bernoulli]
Creators: name: Lengnich, Karl Benjamin
Publisher: name: [s.n.]
Year: 1790

description: von [Carl Benjamin] Lengnich
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Evaluation of platelet transfusions from histocompatibility locus: a matched and nonmatched unrelated donors to thrombocytopenic patients
Creators: name: OwYoung, Judith Grace
Publisher: name: University of Utah
Year: 2012
Subjects: Isolantigens
HLA Antigens

description: Prolonged platelet transfusion therapy often tends towards a refractory state in the thrombocytopenic patient.  This may be caused by alloimmunization (isoimmunizaytion) to platelet antigens, especially transplantation antigens of the Histocompatibility locus-A (HL-A) system.  Histocompatibility between patient and donor is essential for the hemostatic effectiveness of transfused platelets.  In this study, platelet transfusions were studied in 19 patients exhibiting different thrombocytopenic states.  The number and frequency of platelet transfusions were determined by the recipient's physician(s). All patients that received ABO specific non HL-A matched platelets became refractory after 30 units.  Patients that received ABO specific non HL-A matched platelets, bleeding severely and had received blood transfusion six months prior to this study, demonstrated the lowest 20 hour increments of all group investigated.  They demonstrated median and mean increments of 1,230 X M2/unit and 890  X M2.unit  respectively. Patients that received ABO specific non HL-A matched platelets, not actively bleeding and had not received blood transfusions six months or longer prior to this study, responded with a median and mean 20 hour increments of 19,460 X M2/unit and  21,460 X M2/unit respectively.  These values are similar to those of non-sensitized patients receiving non HL-A matched platelets over a short period of time.  One patient received ABO, HL-A matched compatible platelets.  He did not show the expected response.  This was probably due to sensitization to non HL-A antigens and specific platelet antigens from prior numerous blood transfusion.  The patient died soon after admission into the hospital.  Two patients received both HL-A matched platelets.  The median and mean 20 hour increments were 940 X M2/unit and 3,380 X M2/unit with HL-A matched platelets as compared to 200 X M2/unit 400 x M2/unit respectively with non HL-A matched platelets.  The feasibility of establishing a volunteer HL-A platelet donor program was also investigated.  At this time it appears a 100 percent volunteer donor program is not possible until such time of greater public, physician, and blood transfusion services education, and awareness of the necessity of HL-A matched platelets in prolonged platelet therapy.  Utilizing occasional paid donors it was possible to establish a HL-A match platelet transfusion program.
Moving beyond the Lipset hypothesis: examining the correlation between economic development and democracy
Creators: name: Khong, Kevin
Publisher: name: University of Utah
Year: 2012
Subjects: Political culture
South Korea
Politics

description: Following the logic of Seymour Martin Lipset's 1959 hypothesis, the main axis of the  Democratic Transitions debate has long been the strong correlation between economic  development and democracy. More recent empirical evidence puts in doubt the direct  relationship of economic development and democracy in cases where liberal economies  are able to persist without the presupposed necessity for a transition to democracy. This  thesis seeks to investigate the inconsistencies of the correlation between economic  development and democracy. Specifically, why do some countries fail to transition to  democracy despite having high economic development, and why do some countries fail  at developing economically after transitioning to democracy? My findings reject the  preconceived notion that economic development and democracy are directly  intertwined, and propose that certain conditions of political stability and political  legitimacy are required to produce the positive correlation between the two and explain  the role of political institutions in explaining these inconsistencies.
Brief an [Johann Bernoulli]
Creators: name: Langer, Ernst Theodor
Publisher: name: [s.n.]
Year: 1782

description: von [Ernst Theodor] Langer
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Brief an [Johann Bernoulli]
Creators: name: Lengnich, Karl Benjamin
Publisher: name: [s.n.]
Year: 1786

description: von [Carl Benjamin] Lengnich
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Significant parameter identification and characterization of complex in situ reservoir simulations
Creators: name: Bauman, Jacob H.
Publisher: name: University of Utah
Year: 2012
Subjects: In situ
Kerogen pyrolysis
Oil shale
Reservoir modeling
Unconventional fuel
ICSE

description: The energy industry is facing major challenges as world energy demand continues to increase. Unconventional resources, including oil shale, have the capacity to meet that demand as production technology develops. There are many challenges associated with production of fuels from these resources including economics, environmental considerations, sustainability, and government policies. Improving predictive capabilities for energy production from these resources could play a major role in addressing these challenges. Simulation of thermal/reactive reservoir systems is complex. Heat transfers through the rock and fluids by conduction and convection, chemical reactions occur, phases change, multiphase fluids ow, and rock mechanical properties change. Each of these physical processes occurs simultaneously, affecting each other. Important physical processes also occur at widely varying length and time scales. Even where physical process models may be appropriate, the input data are highly uncertain. Useful modeling tools must find a balance between solution accuracy and computational effeciency. Simplifying assumptions are typically made according to data and experience. However, these simplifying assumptions may not be justified where data are sparse and where system characteristics change as a process unfolds. This research explores methods to expose the most important physical parameters and models for making efficient and useful predictions. Reservoir simulation methods for approaching thermal and reactive problems have been explored and analyzed showing heating by conduction alone is slow, and removal of products in a rubble system is not trivial. Experimental design methods have been implemented to expose some important parameters for predicting liquid fuel production, and surrogate models have been created with those parameters that approximate full simulation within 15% accuracy. Expected variations in kinetics and relative permeability modeling parameters predict a normal probability with a mean of 295 bbls (about 39 wt% initial kerogen in place) ultimate oil recovery with a standard deviation of 40 bbls (about 5 wt% initial kerogen in place). A case study involving a hybrid process involving in situ pyrolysis, in situ combustion, and CO2 enhanced oil recovery has shown that the energy input requirement for oil shale heating can be reduced by more than 335 million BTU, or 55%, and produce 160 bbls or 36% more oil. Finally, novel methods for performing these complex simulations are discussed. Progress and challenges with these novel methods are also discussed.
SPRUS : a knowledge based understanding system for radiology text
Creators: name: Ranum, David Leland
Publisher: name: University of Utah
Year: 2012
Subjects: Natural Language Processing
Radiology Information Systems
Software Design

description: A computerized data acquisition tool, SPRUS (Special Purpose Radiology Understanding System), has been implemented as a module in the HELP Hospital Information System.  The tool uses semantic information from a diagnostic expert system to parse free text radiology reports and extract coded findings that are stored in the patient data base.  A unique feature of SPRUS is the ability to recognize ambiguous (missing) information and perform resolution based upon the context of the report and the underlying knowledge base.  Initial test have shown overall True Positive Rates ranging from 0.86 to 0.90 with Bad Data Rates from 0.046 to 0.06.  For diagnostic results, SPRUS shows True Positive Rates from .947 to .986 and Bad Data Rates from 0.04 to 0.06.  Errors (both missed and bad) have been categorized and are discussed with examples in terms of management and future project considerations.  In summary, SPRUS has prototype of understand knowledge based understanding of radiology reports within the HELP Radiology Subsystem.
Inhibition of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae with aromatic sulphonamides and clinically licenced drugs – a joint docking/molecular dynamics study
Creators: name: Bonardi, Alessandro
name: Nocentini, Alessio
name: Osman, Sameh Mohamed
name: Alasmary, Fatmah Ali
name: Almutairi, Tahani Mazyad
name: Abdullah, Dalal Saied
name: Gratteri, Paola
name: Supuran, Claudiu T.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The binding mode of aromatic sulphonamides and clinically licenced drugs to the three carbonic anhydrase (CA, EC 4.2.1.1) isoforms from the human pathogen V. cholerae was here thouroghly characterised by a joint docking and molecular dynamics in silico protocol. In fact, VchCA, VchCAβ, and VchCAγ are crucial in the pathogen life cycle and growth and represent innovative targets to fight V. cholerae proliferation overcoming the spreading chemoresistance to the available drugs. A set of 40 sulphonamides/sulfamates VchCAs inhibitors was studied using the proteins homology built 3 D models unveiling the key and stable interactions responsible for a potent CA inhibition. This study has the aim to offer insights and guidelines for the future rational design of potent and selective inhibitors targeting CA isoforms from V. cholerae or other human pathogens.
Brief an [Johann Bernoulli]
Creators: name: Landi, Antonio
Publisher: name: [s.n.]
Year: 1783

description: Schickt ausgeliehene Bücher zurück. (lettres historiques)
description: von [Antonio] Landi
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Brief an [Johann] Bernoulli
Creators: name: Lengnich, Karl Benjamin
Publisher: name: [s.n.]
Year: 1794

description: von [Carl Benjamin] Lengnich
description: Mit schwarzen Siegelresten
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Brief an [Johann Bernoulli]
Creators: name: Lengnich, Karl Benjamin
Publisher: name: [s.n.]
Year: 1791

description: von [Carl Benjamin] Lengnich
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
The role of dihydropyridine voltage-sensitive calcium channel antagonists as N-methyl-D-aspartate antagonists
Creators: name: Skeen, Gwendolyn Appell
Publisher: name: University of Utah
Year: 2012
Subjects: Mice
Granule Cells

description: Nitrendipine and other 1,4-dihydropyridine (DHP) voltage-sensitive calcium channel (VSCC) antagonists have been shown to possess anticonvulsant and neuroprotectant activity in a variety of model systems. Antagonists of the N-methyl-D-aspartate (NMDA) glutamate receptor subtype are also anticonvulsant and neuroprotectant. Both VSCC and NMDA antagonists exert their effects by inhibiting the neuronal influx of calcium associated with activation of VSCCs or NMDA receptors, respectively. Although results which provide evidence for cross-reactivity between compounds acting at DHP-sensitive VSCCs and NMDA receptors have been reported, direct modulation of NMDA receptor function by DHPs has not been demonstrated.  The objectives of this investigation were to determine (1) if the DHP nitrendipine modulates NMDA receptor function, (2) if this effect of nitrendipine can be observed within various brain structures, (3) the specific mechanism of nitrendipine's interaction with NMDA receptors, and (4) if the effects of nitrendipine are universal for all, or for only specific DHP compounds. Nitrendipine reduced NMDA-evoked calcium flux (measured via the calcium-specific fluorescent probe indo-1) into mouse cerebellar granule cells in a concentration-dependent manner. Over a similar concentration range, nitrendipine reduced the binding of the NMDA antagonist [3H] dizocilpine (MK-801) to mouse brain sections and cortical and hippocampal membranes. Therefore, nitrendipine reduced the function of NMDA receptors throughout mouse brain. A mechanism which could account for nitrendipine's effects on NMDA receptor function was identified via patch clamp electrophysiology with primary cultures of rodent cortical neurons. In these studies, nitrendipine voltage- and use-dependently reduced NMDA-evoked whole-cell current in a manner which was accounted for by reductions in single-channel kinetics (open and burst frequencies and average durations, and the open time constant). Collectively, these results suggest that nitrendipine interacts with NMDA receptors by a mechanism most similar to the open channel trap block model described for the interaction of MK-801 with NMDA receptors. This interaction of nitrendipine with NMDA receptors may be unique amongst the DHPs since similar concentrations of the DHPs nimodipine and nifedipine did not greatly affect NMDA-evoked calcium influx, [3H] MK-801 binding or NMDA-evoked currents.
Anticancer activity and toxicity of new quaternary ammonium geldanamycin derivative salts and their mixtures with potentiators
Creators: name: Skrzypczak, Natalia
name: Pyta, Krystian
name: Ruszkowski, Piotr
name: Mikołajczak, Przemysław
name: Kucińska, Małgorzata
name: Murias, Marek
name: Gdaniec, Maria
name: Bartl, Franz
name: Przybylski, Piotr
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Inorganic Chemistry

description: Geldanamycin (GDM) has been modified by different type neutral/acidic/basic substituents (1–7) and by quinuclidine motif (8), transformed into ammonium salts (9–13) at C(17). These compounds have been characterised by spectroscopic and x-ray methods. Derivative 8 shows better potency than GDM in MCF-7, MDA-MB-231, A549 and HeLa (IC50s = 0.09–1.06 µM). Transformation of 8 into salts 9–13 reduces toxicity (by 11-fold) at attractive potency, e.g. MCF-7 cell line (IC50∼2 µM). Our studies show that higher water solubility contributes to lower toxicity of salts than GDM in healthy CCD39Lu and HDF cells. The use of 13 mixtures with potentiators PEI and DOX enhanced anticancer effects from IC50∼2 µM to IC50∼0.5 µM in SKBR-3, SKOV-3, and PC-3 cancer cells, relative to 13. Docking studies showed that complexes between quinuclidine-bearing 8–13 and Hsp90 are stabilised by extra hydrophobic interactions between the C(17)-arms and K58 or Y61 of Hsp90.
Design, synthesis, HER2 inhibition and anticancer evaluation of new substituted 1,5-dihydro-4,1-benzoxazepines
Creators: name: Cruz-López, Olga
name: Ner, Matilde
name: Nerín-Fonz, Francho
name: Jiménez-Martínez, Yaiza
name: Araripe, David
name: Marchal, Juan A.
name: Boulaiz, Houria
name: Gutiérrez-de-Terán, Hugo
name: Campos, Joaquín M.
name: Conejo-García, Ana
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: A series of 11 new substituted 1,5-dihydro-4,1-benzoxazepine derivatives was synthesised to study the influence of the methyl group in the 1-(benzenesulphonyl) moiety, the replacement of the purine by the benzotriazole bioisosteric analogue, and the introduction of a bulky substituent at position 6 of the purine, on the biological effects. Their inhibition against isolated HER2 was studied and the structure–activity relationships have been confirmed by molecular modelling studies. The most potent compound against isolated HER2 is 9a with an IC50 of 7.31 µM. We have investigated the effects of the target compounds on cell proliferation. The most active compound (7c) against all the tumour cell lines studied (IC50 0.42–0.86 µM) does not produce any modification in the expression of pro-caspase 3, but increases the caspase 1 expression, and promotes pyroptosis.
Brief an Christfr[ied] Kirch
Creators: name: Lange, Johann Joachim
Publisher: name: [s.n.]
Year: 1736

description: von Johann Joachim Lange
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
title: The Fun is Just Beginning: Juggling Values-Based Practice in a High-Stakes World (23rd Health Sciences Lively Lunchtime Discussion)
title: The Fun is Just Beginning: Juggling Values-Based Practice in a High-Stakes World (The 23rd Health Sciences Lively Lunchtime Discussion)
titleType: AlternativeTitle
Creators: name: Kubilius, Ramune K.
name: McLellan, Andrea
name: Cox, Christopher
name: Tzoc, Elías
name: Speer, Elizabeth
Publisher: name: Prism. Galter Health Sciences Library. Northwestern University
Year: 2023
Subjects: subject: Libraries, Medical
subject: Library Collection Development
subject: Artificial intelligence
subject: Artificial Intelligence
subject: Collection management (Libraries)
subject: Library budgets
subject: Collection audits

description: Compilation includes: 1) Handout, prepared for and presented in synopsis during a brief (traditional) annual update of interesting and noteworthy trends in the health publishing and health information sectors that occurred or were noticed since the 2022 Health Sciences Lively Lunch at the Charleston Conference: Issues in Book and Serial Acquisition. 2-4) Session presentation slides of: Andrea McLellan (McMaster University Health Sciences Library), Elizabeth Speer (University of North Texas Health Sciences Center), Chris (Christopher) Cox and Elias Tzoc (Clemson University).  (The 23rd Lively Lunch took place on Thursday, November 9, 2023 in Charleston, SC and was repeated during online conference week on November 30, 2023; Elizabeth Speer pre-recorded presentation for the Charleston audience). Version 2 post conference compilation includes added appendices to Speer and Cox/Tzoc slide decks.
Vanillin enones as selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII. The out of the active site pocket for the design of selective inhibitors?
Creators: name: Riafrecha, Leonardo E.
name: Le Pors, Macarena S.
name: Lavecchia, Martín J.
name: Bua, Silvia
name: Supuran, Claudiu T.
name: Colinas, Pedro A.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: New C-glycosides and α,β-unsaturated ketones incorporating the 4-hydroxy-3-methoxyphenyl (vanillin) moiety as inhibitors of carbonic anhydrase (CA, EC 4.2.1.1) isoforms have been investigated. The inhibition profile of these compounds is presented against four human CA (hCA) isozymes, comprising hCAs I and II (cytosolic, ubiquitous enzymes) and hCAs IX and XII (tumour associated isozymes). Docking analysis of the inhibitors within the active sites of these enzymes has been performed and is discussed, showing that the observed selectivity could be explained in terms of an alternative pocket out of the CA active site where some of these compounds may bind. Several derivatives were identified as selective inhibitors of the tumour-associated hCA IX and XII. Their discovery might be a step in the strategy for finding an effective non-sulfonamide CA inhibitor useful in therapy/diagnosis of hypoxic tumours or other pathologies in which CA isoforms are involved.
title: The Fun is Just Beginning: Juggling Values-Based Practice in a High-Stakes World (23rd Health Sciences Lively Lunchtime Discussion)
title: The Fun is Just Beginning: Juggling Values-Based Practice in a High-Stakes World (The 23rd Health Sciences Lively Lunchtime Discussion)
titleType: AlternativeTitle
Creators: name: Kubilius, Ramune K.
name: McLellan, Andrea
name: Cox, Christopher
name: Tzoc, Elías
name: Speer, Elizabeth
Publisher: name: Prism. Galter Health Sciences Library. Northwestern University
Year: 2023
Subjects: subject: Library budgets
subject: Collection audits
subject: Artificial intelligence
subject: Collection management (Libraries)
subject: Artificial Intelligence
subject: Libraries, Medical
subject: Library Collection Development

description: Compilation includes: 1) Handout, prepared for and presented in synopsis during a brief (traditional) annual update of interesting and noteworthy trends in the health publishing and health information sectors that occurred or were noticed since the 2022 Health Sciences Lively Lunch at the Charleston Conference: Issues in Book and Serial Acquisition. 2-4) Session presentation slides of: Andrea McLellan (McMaster University Health Sciences Library), Elizabeth Speer (University of North Texas Health Sciences Center), Chris (Christopher) Cox and Elias Tzoc (Clemson University).  (The 23rd Lively Lunch took place on Thursday, November 9, 2023 in Charleston, SC and was repeated during online conference week on November 30, 2023; Elizabeth Speer pre-recorded presentation for the Charleston audience)
Development of novel isatin–nicotinohydrazide hybrids with potent activity against susceptible/resistant Mycobacterium tuberculosis and bronchitis causing–bacteria
Creators: name: Elsayed, Zainab M.
name: Eldehna, Wagdy M.
name: Abdel-Aziz, Marwa M.
name: Hassab, Mahmoud A. El
name: Elkaeed, Eslam B.
name: Al-Warhi, Tarfah
name: Abdel-Aziz, Hatem A.
name: Abou-Seri, Sahar M.
name: Mohammed, Eman R.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Joining the global fight against Tuberculosis, the world's most deadly infectious disease, herein we present the design and synthesis of novel isatin-nicotinohydrazide hybrids (5a–m and 9a–c) as promising anti-tubercular and antibacterial agents. The anti-tubercular activity of the target hybrids was evaluated against drug-susceptible M. tuberculosis strain (ATCC 27294) where hybrids 5d, 5g and 5h were found to be as potent as INH with MIC = 0.24 µg/mL, also the activity was evaluated against Isoniazid/Streptomycin resistant M. tuberculosis (ATCC 35823) where compounds 5g and 5h showed excellent activity (MIC = 3.9 µg/mL). Moreover, the target hybrids were examined against six bronchitis causing-bacteria. Most derivatives exhibited excellent antibacterial activity. K. pneumonia emerged as the most sensitive strain with MIC range: 0.49–7.81 µg/mL. Furthermore, a molecular docking study has proposed DprE1 as a probable enzymatic target for herein reported isatin-nicotinohydrazide hybrids, and explored the binding interactions within the vicinity of DprE1 active site.
Brief an [Johann] Bernoulli
Creators: name: Lengnich, Karl Benjamin
Publisher: name: [s.n.]
Year: 1786

description: von [Carl Benjamin] Lengnich
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Design and characterisation of piperazine-benzofuran integrated dinitrobenzenesulfonamide as Mycobacterium tuberculosis H37Rv strain inhibitors
Creators: name: Murthy, Vallabhaneni S.
name: Tamboli, Yasinalli
name: Krishna, Vagolu Siva
name: Sriram, Dharmarajan
name: Ansari, Siddique Akber
name: Alarfaj, Abdullah A.
name: Hirad, Abdurahman H.
name: Vijayakumar, Vijayaparthasarathi
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Molecular hybridisation of four bioactive fragments piperazine, substituted-benzofuran, amino acids, and 2,4-dinitrobenzenesulfonamide as single molecular architecture was designed. A series of new hybrids were synthesised and subjected to evaluation for their inhibitory activity against Mycobacterium tuberculosis (Mtb) H37Rv. 4d–f and 4o found to exhibit MIC as 1.56 µg/mL, equally active as ethambutol whereas 4a, 4c, 4j displayed MIC 0.78 µg/mL were superior to ethambutol. Tested compounds demonstrated an excellent safety profile with very low toxicity, good selectivity index, and antioxidant properties. All the newly synthesised compounds were thoroughly characterised by analytical methods. The result was further supported by molecular modelling studies on the crystal structure of Mycobacterium tuberculosis enoyl reductase.
Cyclocephala picipes
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala picipes

description: Cyclocephala picipes (Olivier, 1789)
Melolontha picipes Olivier 1789: 80 (French Guiana)
Distribution. Suriname: MHCN - NEW COUNTRY RECORD (Suriname, Brokopondo, Bergendal Resort, (5°09′00″N, 55°04′15″W). 1/ 10-II-2014. A. J. Hielkema. Flying at light.); NZCS. French Guiana: Endrödi 1966a: 283 (designation NEOTYPE Melolontha picipes), 1985a: 85, 121; Lachaume 1992: 15; Ratcliffe 1992: 185; Brûlé et al. 2011a: 191, 2014: 181; Duranton 2011: 14; Ponchel 2011: 60; Dupuis 2016b: 109; Moore et al. 2018b: 230; MHCN. Brazil (NA): Arrow 1937b: 14; Blackwelder 1944: 252; Ratcliffe 1992: 185 (NA); Moore et al. 2018b: 230. Venezuela (EO): Kirmse and Ratcliffe 2019: 153 (EO). Other: Olivier 1789: 80 (none).
Note. Moore et al. (2018b: 107) conclude that the neotype of Melolontha picipes designated in Endrödi (1966a: 283) is invalid because it violates several demands of Article 75 of the ICZN (1964: 81).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 178, DOI: 10.5281/zenodo.3678492
Brief an [Johann Bernoulli]
Creators: name: Langguth, Christian August
Publisher: name: [s.n.]
Year: 1786

description: von [Christian August] Langguth
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
description: Bl. 29-30: 2 gedruckte Anzeigen
description: Bl. 31-33: 3 Kupf. eines botanischen Werks
Prostitution policy and the function of silence: the communicative constitution of a clandestine (un)organization
Creators: name: Taylor, Julie Lynn
Publisher: name: University of Utah
Year: 2014
Subjects: Clandestine organization
Communication constitutes organizing
Discourse
Feminist poststructuralism
Prostitution policy
Silence

description: While often hailed as the world's oldest profession, prostitution is most commonly considered an illegal activity. As such, prostitution operates as a hidden organization relying on covert organizing processes in order to function. However, this reality begs the question of how hidden organizations operate and (re)produce. Through feminist poststructuralism and communication as constitutive to organizing, the research questions in this study ask how discourse(s) communicatively constitute prostitution and with what unintended consequences. Using local prostitution policies and in-depth interviews, data analysis revealed that policy-as-written and policy-as-practice are disparate in the communicative construction of organizing prostitution. Moreover, discourse is examined through both talk and silence. As a result systematic and pervasive silence(s) organized networks of prostitution in new ways. In the end, prostitution is highlighted as an organized network or rather an (un)organization.
Brief an Johann Bernoulli
Creators: name: Lengnich, Karl Benjamin
Publisher: name: [s.n.]
Year: 1789

description: von [Carl Benjamin] Lengnich
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Brief an [Johann] Bernoulli
Creators: name: Lengnich, Karl Benjamin
Publisher: name: [s.n.]
Year: 1787

description: von [Carl Benjamin] Lengnich
description: Mit Spuren von einer Oblate
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
description: Bl. 258: J. Uphagen an Lengnich, 26. Juli 1787
Learning statistics in the computer lab
Creators: name: Knaeble, Brian
Publisher: name: University of Utah
Year: 2012
Subjects: Learning
Computer lab

description: The purpose of this dissertation was to create a textbook that supplements traditional statistics curriculum. Emphasis was placed on statistical computing. Multiple computing environments were used to demonstrate essential skills for the applied statistican. Mathematical theory was developed in order to make the text self contained. A technique was developed to replace a faulty command for computing moment generating functions within Mathematica.
Pressure-assisted ozonation and aeration of activated sludge for cell rupturing and anaerobic digestion enhancement
Creators: name: Cheng, Chia-Jung
Publisher: name: University of Utah
Year: 2012
Subjects: Activated sludge
Ozonation
Anaerobic digestion

description: The generation of a large volume of activated sludge (AS) from wastewater treatment has increasingly become a great burden on the environment. Anaerobic digestion is routinely practiced for excess waste sludge; however, the process retention time is long because of kinetic limitation in the hydrolysis step. This study tested the feasibility of applying cycles of pressure-assisted ozonation (PAO) to enhance the disintegration and solubilization of AS for digestion using reduced ozone dose and contact time. The kinetics of solid reduction and biogas production of PAO-treated sludge are evaluated in this study. The ultimate goal is to introduce an effective treatment method that produces increased soluble organic contents from AS for enhanced excess sludge reduction and biogas production during conventional anaerobic digestion. Results show that for the returned AS with total chemical oxygen demand (tCOD) of 8200 mg L-1, a dose of 0.01 g O3 g-1 total suspended solids (TSS) delivered via 20 pressure cycles within 16 min resulted in a 37-fold increase of the sCOD/tCOD ratio (due to increased soluble COD, i.e., sCOD) and a 25% reduction of TSS, in comparison to a dose of 0.08 g O3 g-1 TSS via bubbling contact over 15 min that resulted in a 15-fold increase of the sCOD/tCOD ratio and a 12% reduction of TSS. Sludge solubilization was evidenced by increased dissolved contents of total phosphorous (from 10 to 64 mg L-1), total nitrogen (from 14 to 120 mg L-1), and protein (from < 15 to 39 mg L-1) in the sludge suspension after treatment, indicating significant solubilization of AS. The subsequent anaerobic digestion tests showed solids reduction to be significantly dependant on food-to-inoculum (F/I) ratios in the range 0.5 to 2 rather than treatments when unacclimated inoculum was used. However, improvements of solids reduction and biogas production by conventional ozonation and PAO resulted when using acclimated inocula at F/I = 0.4 to 0.8. Using PAO at a smaller dose (10 mg O3 g-1 TSS) at F/I of 0.8, VSS reduction and biogas production were 1.4- and 2.6-fold higher, respectively, than those of conventional ozonation (52 mg O3 g-1 TSS). This study has demonstrated the advantage of using PAO in disrupting excess activated sludge and in terms of improved solids reduction and biogas production during subsequent anaerobic digestion.
Brief an [Johann] Bernoulli
Creators: name: Lengnich, Karl Benjamin
Publisher: name: [s.n.]
Year: 1787

description: von [Carl Benjamin] Lengnich
description: Mit Oblate
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Molecular design, synthesis and in vitro biological evaluation of thienopyrimidine–hydroxamic acids as chimeric kinase HDAC inhibitors: a challenging approach to combat cancer
Creators: name: Abdel-Atty, Mona M.
name: Farag, Nahla A.
name: Serya, Rabah A. T.
name: Abouzid, Khaled A. M.
name: Mowafy, Samar
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: A series of thieno[2,3-d]pyrimidine-based hydroxamic acid hybrids was designed and synthesised as multitarget anti-cancer agents, through incorporating the pharmacophore of EGFR, VEGFR2 into the inhibitory functionality of HDAC6. Three compounds (12c, 15b and 20b) were promising hits, whereas (12c) exhibited potent VEGFR2 inhibition (IC50=185 nM), potent EGFR inhibition (IC50=1.14 µM), and mild HDAC6 inhibition (23% inhibition). Moreover, compound (15c) was the most potent dual inhibitor among all the synthesised compounds, as it exhibited potent EGFR and VEGFR2 inhibition (IC50=19 nM) and (IC50=5.58 µM), respectively. While compounds (20d) and (7c) displayed nanomolar selective kinase inhibition with EGFR IC50= 68 nM and VEGFR2 IC50= 191 nM, respectively. All of the synthesised compounds were screened in vitro for their cytotoxic effect on 60 human NCI tumour cell lines. Additionally, molecular docking studies and ADMET studies were carried out to gain further insight into their binding mode and predict the pharmacokinetic properties of all the synthesised inhibitors.
Cyclocephala poncheli Dechambre and Duranton 2005
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala poncheli

description: Cyclocephala poncheli Dechambre and Duranton, 2005
Cyclocephala poncheli Dechambre and Duranton 2005: 69 (French Guiana)
Distribution. French Guiana: Dechambre and Duranton 2005: 69; Ponchel 2011: 60; Dupuis 2016b: 109; Moore et al. 2018b: 232.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 178, DOI: 10.5281/zenodo.3678492
Brief an Johann Bernoulli
Creators: name: Lengnich, Karl Benjamin
Publisher: name: [s.n.]
Year: 1794

description: von [Carl Benjamin] Lengnich
description: Mit Oblate
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Dammarane triterpenes targeting α-synuclein: biological activity and evaluation of binding sites by molecular docking
Creators: name: Cornejo, Alberto
name: Caballero, Julio
name: Simirgiotis, Mario
name: Torres, Vanessa
name: Sánchez, Luisa
name: Díaz, Nicolás
name: Guimaraes, Marcela
name: Hernández, Marcos
name: Areche, Carlos
name: Alfaro, Sergio
name: Caballero, Leonardo
name: Melo, Francisco
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Neuroscience
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Parkinson's disease (PD) is a neurodegenerative disorder that affects adult people whose treatment is palliative. Thus, we decided to test three dammarane triterpenes 1, 1a, 1b, and we determined that 1 and 1a inhibit β-aggregation through thioflavine T rather than 1b. Since compound 1 was most active, we determined the interaction between α-synuclein and 1 at 50 µM (Kd) through microscale thermophoresis. Also, we observed differences in height and diameter of aggregates, and α-synuclein remains unfolded in the presence of 1. Also, aggregates treated with 1 do not provoke neurites' retraction in N2a cells previously induced by retinoic acid. Finally, we studied the potential sites of interaction between 1 with α-synuclein fibrils using molecular modelling. Docking experiments suggest that 1 preferably interact with the site 2 of α-synuclein through hydrogen bonds with residues Y39 and T44.
3S RECIPE – Smart Shrinkage Solutions: Timisoara (RO) Policy Brief #3. Liveability
Creators: name: Nadolu, Bogdan
name: Dincă, Melinda
name: Daniel, Lucheş
name: Raceanu, Corina
name: Mykhnenko, Vlad
Publisher: name: Zenodo
Year: 2020
Subjects: smart
solutions
shrinking
cities
urban
futures
resilience
intervention

description: This policy brief showcases a successful initiative to improve urban liveability through the implementation of smart city technologies as a coherent measure to prevent and mitigate further demographic decline in Timișoara, a middle size city in western Romania. Following the city’s successful popular uprising against the communist dictatorship of Nicolae Ceaușescu in 1989, Timișoara has experienced a comprehensive transition towards a multi-party democracy, a pluralist society, and a liberal market-based economy.
 Romania’s legalisation of abortion in 1990, combined with a gradual introduction of the pan-European freedom of movement regime during the 1990s and early 2000s, has led to further social changes across the country: birth control, out-migration, and rampant urban sprawl have resulted in Timișoara losing well over 50,000 inhabitants. Though the present population has stabilised at around 330,000, the city’s geographical proximity to five major European capitals, and its excellent highway connections with western Europe remain a constant pull factor, putting a pressure on the municipality to increase the city’s attractiveness and liveability. Building on local knowledge and the stakeholders’ experience in implementing this project, this policy brief demonstrates how smart city solutions can contribute to liveability in the inner city as well as in the broader metropolitan area. It also offers a set of policy recommendations on how to enable such an effective public intervention on a city scale.
description: 3S RECIPE is part of the Joint Programming Initiative (JPI) Urban Europe's ERA-NET Cofund Smart Urban Futures Call (ENSUF). This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 857160.