cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Coherent Control of Isotope Separation in HD+ Photodissociation by Strong Fields
Creators: name: Charron, Eric
name: Giusti-Suzor, Annick
name: Mies, Frederick
Publisher: name: arXiv
Year: 1995
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: The photodissociation of the HD+ molecular ion in intense short- pulsed linearly polarized laser fields is studied using a time- dependent wave-packet approach where molecular rotation is fully included. We show that applying a coherent superposition of the fundamental radiation with its second harmonic can lead to asymmetries in the fragment angular distributions, with significant differences between the hydrogen and deuterium distributions in the long wavelength domain where the permanent dipole is most efficient. This effect is used to induce an appreciable isotope separation.
description: Physical Review Letters, 1995 (in press). 4 pages in revtex format, 3 uuencoded figures. Full postcript version available at: http://chemphys.weizmann.ac.il/~charron/prl.ps or ftp://scipion.ppm.u-psud.fr/coherent.control/prl.ps
TV_LPTBGI 2023 cruise,Marion Dufresne R/V
Creators: name: Benoit, LOUBRIEU
name: Javier, ESCARTIN
Publisher: name: Sismer
Year: 2023

description: Initiative « Valorisation bathymétrique des transits de la flotte océanographique » L'acquisition de données bathymétriques sur ce transit est à l¿initiative d'un groupe de géologues et géophysiciens , en concertation avec la Flotte Océanographique Française. L'objectif global de cette initiative est de généraliser l¿acquisition de données de sondeurs multifaisceaux sur les transits des navires de la flotte, en vue de a) compléter les couvertures bathymétriques existantes à moyenne et haute résolution et contribuer à la cartographie bathymétrique globale des océans, b) établir un protocole d¿acquisition ettraitement des données des transits valorisées, et c) faciliter les travaux de recherche à travers le partage publique des données acquises lors de ces transits. Les données sont destinées à un usage de cartographie moyenne résolution (modèle numérique de terrain au pas de grille d¿une centaine de mètres). L'acquisition de données se fait dans un mode contraint : - la vitesse du navire est celle fixée par le transit, sans ajustement vis-à-vis de la qualité des données ou leur résolution. - le sondeur multifaisceaux est placé dans un mode automatique. L¿acquisition n¿est pas nécessairement suivie en continu par un opérateur spécialisé. - les profils de célérité utilisés pour l¿acquisition des données et le calcul des sondes sont établis à partir de tables globales, sans mesure in-situ de température et salinité lors de l¿acquisition (de type sondes de température). Les données sont pré-traitées et validées et sont destinées à être mise à disposition à court terme dans la base de données des navires océanographiques Sismer. L'acquisition est limitée aux eaux internationales, pour lesquelles aucune demande d¿autorisation n¿est nécessaire. Cette initiative se fait également en interaction avec le projet Seabed2030 (seabed2030.org).
Engineering synthetic receptors in Bacillus subtilis
Creators: name: Samson, Jennifer Adele
Publisher: name: Imperial College London
Year: 2015

description: Engineering signaling processes is central to building customized cells with bespoke novel functions. However, there are relatively few examples of engineering cellular control in response to artificial extracellular ligands, likely due to the complexity of engineering receptor sensor elements. Increasingly, there is also agreement that we may further our current understanding of endogenous signaling pathways through engineering new signaling behaviours. The lack of control over when and how bacterial endospores germinate has limited their use as a potential chassis for biotechnology purposes. Despite spore germination being best described in Bacillus subilis, there are still many fundamental questions about the mechanisms underlying germination. Yet, spores offer attractive characteristics over other candidates for use in biotechnology since they are inexpensive to prepare, are able to withstand harsh environmental conditions and can be stored at room temperature after dessication. Here, we describe a novel sensor system in spores of Bacillus subtilis that can detect small molecules, peptides and protein ligands. We exploit the modularity of a kinase germination receptor to engineer control over spore germination using synthetic receptors. Through engineering synthetic germination receptors we reveal unknown features of endogenous germination pathways in B. subtilis. This research contributes to our understanding of germination behaviour in B. subtilis spores and the complexity of which is necessary to understand in order for the potential of spore-based applications in biotechnology to be achieved. Using the same engineering strategy, we also describe how a synthetic receptor may regulate gene expression in cells of B. subtilis, which demonstrates the robustness of this approach.
Reconstructing $f(R)$ gravity from the spectral index
Creators: name: Chiba, Takeshi
Publisher: name: arXiv
Year: 2018
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Recent cosmological observations are in good agreement with the scalar spectral index $n_s$ with $n_s-1\simeq -2/N$, where $N$ is the number of e-foldings. In the previous work, the reconstruction of the inflaton potential for a given $n_s$ was studied, and it was found that for $n_s-1=-2/N$, the potential takes the form of either $α$-attractor model or chaotic inflation model with $ϕ^2$ to the leading order in the slow-roll approximation. Here we consider the reconstruction of $f(R)$ gravity model for a given $n_s$ both in the Einstein frame and in the Jordan frame. We find that for $n_s-1=-2/N$ (or more general $n_s-1=-p/N$), $f(R)$ is given parametrically and is found to asymptote to $R^2$ for large $R$. This behavior is generic as long as the scalar potential is of slow-roll type.
description: 8 pages, 2 figures, references added, version to appear in PTEP
The Lx-T Relation and Intracluster Gas Fractions of X-ray Clusters
Creators: name: Arnaud, Monique
name: Evrard, August E.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We re-examine the X-ray luminosity-temperature relation using a nearly homogeneous data set of 24 clusters selected for statistically accurate temperature measurements and absence of strong cooling flows. The data exhibit a remarkably tight power-law relation between bolometric luminosity and temperature with a slope 2.88 \pm 0.15. With reasonable assumptions regarding cluster structure, we infer an upper limit on fractional variations in the intracluster gas fraction
description: 11 pages, 4 figures, uses mn.sty and epsf.sty, accepted for publication in MNRAS; minor modifications: discussion added on CF LX (Sec. 3.1);comparison with Allen & Fabian L-T results (Sec.3.1 & Sec.4.4); statistics precised (3.1), discussion clarified (Sec. 2.2,Sec. 4.4); slight mistake in the r-T and M-T relation calibration corrected and thus fgas in Fig.3, Fig 4, Tab 2 slightly changed
Wave dynamics alteration by discontinuous flexible mats of artificial seagrass can support seagrass restoration efforts
Creators: name: Villanueva, Raúl
name: Paul, Maike
name: Schlurmann, Torsten
Publisher: name: [London] : Macmillan Publishers Limited, part of Springer Nature
Year: 2023
Subjects: subject: Hydrodynamics
subject: coconut
subject: field study
subject: hydrodynamics
subject: motion
subject: Dewey Decimal Classification::500 | Naturwissenschaften
subject: Dewey Decimal Classification::600 | Technik

description: Seagrass restoration can be promoted through the use of artificial seagrass (ASG). However, there is no guideline for ASG design, which requires a sound understanding of the inherent hydrodynamics in a submerged environment. Present know-how primarily stems from idealized ASG attached to a fixed bed. To develop accessible field deployment for restoration, anchored prototype scale ASG mats (coconut mesh) were proposed and tested under differing wave conditions. The aim of this study was then to: 1) analyze hydrodynamic interaction of ASG mats; and 2) assess the suitability of contemporary predictive hydrodynamic models. Velocity structure and wave propagation were measured around one and two ASG mats (separated by a 2-m gap). The mats reduced orbital velocities by up to 16% (2 mats), whereby the average reduction of all tested vegetated conditions was low (< 10 %) compared to the non-vegetated conditions. Velocities increased above the ASG, with the gap enhancing velocity (up to 11%) instead of attenuating it. Wave decay followed an exponential decrease, further enhanced by the second mat. Current models did not capture the induced hydrodynamics for the full range of wave conditions tested, with the second mat increasing uncertainties. Wave decay models generally overestimated wave attenuation (up to 30%), except for longer wave periods. Nevertheless, for the full range of conditions, the models provide accurate insight into the expected magnitude of attenuation under field conditions. It is speculated that mat flexibility affects the surrounding hydrodynamics through inherent motion, with the gap contributing to the uncertainties.
TV_RECLPT 2023 cruise,Marion Dufresne R/V
Creators: name: Benoit, LOUBRIEU
name: Javier, ESCARTIN
Publisher: name: Sismer
Year: 2023

description: L'acquisition de données bathymétriques sur ce transit est l'initiative d'un groupe de géologues et de géophysiciens, en consultation avec la Flotte Océanographique Française. L'objectif global de cette initiative est de généraliser l'acquisition de données de sondeurs multifaisceaux lors des transits des navires de recherche français, afin de a) combler les lacunes de la couverture bathymétrique moyenne résolution existante et contribuer à la cartographie bathymétrique globale des océans, b) établir un protocole pour l'acquisition, le traitement et la valorisation des données, et c) faciliter les travaux de recherche par le partage public des données acquises lors de ces transits. Les données sont destinées à être utilisées pour la cartographie à moyenne résolution (modèle numérique de terrain avec un maillage d'environ 100 mètres). L'acquisition des données pendant le transit peut être contrainte : - la vitesse du navire est celle fixée par le transit, sans ajustement en ce qui concerne la qualité des données ou leur résolution. - le sondeur multifaisceaux est placé en mode automatique. L'acquisition en temps réel n'est pas nécessairement suivie en continu par un opérateur spécialisé. - les profils de vitesse du son utilisés pour l'acquisition des données sont établis à partir de tables globales de température et de salinité, sans mesures in-situ lors de l'acquisition (sondes de température). Les données sont prétraitées et validées et sont destinées à être mises à disposition à court terme via la base de données des navires de recherche de l'Ifremer Sismer. L'acquisition est limitée aux eaux internationales, pour lesquelles aucune demande d'autorisation n'est nécessaire. Cette initiative est également en interaction avec le projet Seabed2030 (seabed2030.org).
Anomalous normal state resistivity in superconducting $La_{2-x}Ce_xCuO_4$: Fermi liquid or strange metal?
Creators: name: Sarkar, Tarapada
name: Greene, Richard L.
name: Sarma, S. Das
Publisher: name: arXiv
Year: 2018
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We present experimental results for the in-plane resistivity of the electron-doped cuprate superconductor $La_{2-x}Ce_xCuO_4$ above its transition temperature $T_c$ as a function of Ce doping x and temperature. For the doping x between 0.11 and 0.17, where $T_c$ varies from 30 K (x=0.11) to 5 K (x=0.17), we find that the resistivity shows an approximate $T^2$ behavior for all values of doping over the measurement range from 100 K to 400 K. The coefficient of the $T^2$ resistivity term decreases with increasing x following the trend in $T_c$. We analyze our data theoretically and posit that n-type cuprates are better thought of as strange metals. Although the quadratic temperature dependence appears to be in naive agreement with the Fermi liquid (FL) expectations, the fact that the measured resistivity is large and no phonon-induced linear-in-T resistivity manifests itself even at 400 K argue against a standard normal metal Fermi liquid picture being applicable. We discuss possible origins of the strange metal behavior.
description: 18 Pages, 5 figures (any comments are welcome)
Bond Orientational Order, Molecular Motion and Free Energy of High Density DNA Mesophases
Creators: name: Podgornik, R.
name: Strey, H. H.
name: Gawrisch, K.
name: Rau, D. C.
name: Rupprecht, A.
name: Parsegian, V. A.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: By equilibrating condensed DNA arrays against reservoirs of known osmotic stress and examining them with several structural probes, it has been possible to achieve a detailed thermodynamic and structural characterization of the change between two distinct regions on the liquid crystalline phase digram: a higher-density hexagonally packed region with long-range bond orientational order in the plane perpendicular to the average molecular direction; and a lower-density cholesteric region with fluid-like positional order. X-rays scattering on highly ordered DNA arrays at high density and with the helical axis oriented parallel to the incoming beam showed a six-fold azimuthal modulation of the first order diffraction peak that reflects the macroscopic bond-orientational order. Transition to the less-dense cholesteric phase through osmotically controlled swelling shows the loss of this bond orientational order that had been expected from the change in optical birefringence patterns and that is consistent with a rapid onset of molecular positional disorder. This change in motion was previously inferred from intermolecular force measurements and is now confirmed by $\rm ^{31}P$ NMR. Controlled reversible swelling and compaction under osmotic stress, spanning a range of densities between $\sim 120$ mg/ml to $\sim 600$ mg/ml, allows measurement of the free energy changes throughout each phase and at the phase transition, essential information for theories of liquid-crystalline states.
description: 14 pages, 3 figures in gif format available at http://abulafia.mgsl.dcrt.nih.gov/pics.html E-mail: rudi@helix.nih.gov
Additional file 1 of Shifting the microbiome of a coral holobiont and improving host physiology by inoculation with a potentially beneficial bacterial consortium
Creators: name: Zhang, Ying
name: Yang, Qingsong
name: Ling, Juan
name: Long, Lijuan
name: Huang, Hui
name: Yin, Jianping
name: Wu, Meilin
name: Tang, Xiaoyu
name: Lin, Xiancheng
name: Zhang, Yanying
name: Dong, Junde
Publisher: name: figshare
Year: 2021
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional file 1: Figure S1. Average protein concentrations (a), carbohydrate concentrations (b) and lipid concentrations (c) in the placebo (white bars) and BMC (gray bars) group on days 7, 14, and 21. All averages are standardized to grams of ash-free dry tissue weight (gdw), n=6. * and ** indicate significant differences at P<0.05 and P<0.01, respectively. Bars represent the standard deviation of the mean. Figure S2. (a) Chlorophyll-a concentration of BMC (triangle) versus placebo (circle) and are standardized to the ash-free dry weight of the sample. (b) The maximum quantum yields of the PSII photochemistry (Fv/Fm) was determined at the day before the end of experiment. Number of coral fragments: Fv/Fm, n=4 and chlorophyll-a, n=6. Figure S3. Principal coordinates analysis (PCoA) of Pocillopora damicornis microbiome in the placebo (red) and BMC (blue) group on days 7 (b), 14 (c), 21 (d) and three time points (a), based on Bray-Curtis dissimilarity index, n = 6. Table S1. Characteristics of the bacteria strains used to generate the inoculation bacterial consortium. nt: nucleotides.
Pretreating with cannabidiol (CBD) enhances chemotherapy: evidence for mitochondrial "priming"
Creators: name: Henley, Aine
Publisher: name: Imperial College London
Year: 2015

description: The current treatment for cancer is focused on chemotherapeutic treatments which can lead to many side effects including nausea, vomiting and chemoresistance. Combating chemoresistance is a key target in cancer therapy, along with enhancing the effects of current chemotherapy treatments. One progressive novel approach being investigated is pre-treating (“priming”) cells prior to chemotherapeutic treatment. Evidence has shown that “priming” of cancer cells can sensitizes the mitochondria to respond better to chemotherapy and hence reduce severity of treatment and side effects. In this thesis, I aim to define the mechanism by which “priming” enhances cell death through the mitochondria. Firstly, cannabidiol (CBD), a phytocannabinoid that has shown to have beneficial properties in inflammation, pain relief and in reducing cancer cell progression was examined for a potential “priming” agent. Secondly, the effect of the chemotherapy agent, cisplatin, was fully defined for its role in mitochondrial function along with a combination therapy of CBD and cisplatin. And finally, “priming” with CBD was assessed for any potential benefit to cancer treatment. I have demonstrated here that “priming” with CBD can enhance the killing effect of cisplatin in cancer cells and not in control cells. More specifically, the underlying mechanism for “priming” by CBD was shown to be through the modulation of mitochondrial function by means of the high stress two-phase system p53/Nrf2 together with voltage dependant anion channel 1 (VDAC1) receptor activation. From this body of work, “priming” has been shown to have a potential in enhancing current chemotherapeutic treatment.
TV_HORBES 2023 cruise,L'Atalante R/V
Creators: name: Benoit, LOUBRIEU
name: Javier, ESCARTIN
Publisher: name: Sismer
Year: 2023

description: Initiative « Valorisation bathymétrique des transits de la flotte océanographique » L'acquisition de données bathymétriques sur ce transit est à l'initiative d'un groupe de géologues et géophysiciens , en concertation avec la Flotte Océanographique Française. L'objectif global de cette initiative est de généraliser l'acquisition de données de sondeurs multifaisceaux sur les transits des navires de la flotte, en vue de a) compléter les couvertures bathymétriques existantes à moyenne et haute résolution et contribuer à la cartographie bathymétrique globale des océans, b) établir un protocole d'acquisition et traitement des données des transits valorisées, et c) faciliter les travaux de recherche à travers le partage publique des données acquises lors de ces transits. Les données sont destinées à un usage de cartographie moyenne résolution (modèle numérique de terrain au pas de grille d'une centaine de mètres). L'acquisition de données se fait dans un mode contraint : - la vitesse du navire est celle fixée par le transit, sans ajustement vis-à-vis de la qualité des données ou leur résolution. - le sondeur multifaisceaux est placé dans un mode automatique. L'acquisition n'est pas nécessairement suivie en continu par un opérateur spécialisé. - les profils de célérité utilisés pour l¿acquisition des données et le calcul des sondes sont établis à partir de tables globales, sans mesure in-situ de température et salinité lors de l'acquisition (de type sondes de température). Les données sont pré-traitées et validées et sont destinées à être mise à disposition à court terme dans la base de données des navires océanographiques Sismer. L'acquisition est limitée aux eaux internationales, pour lesquelles aucune demande d'autorisation n'est nécessaire. Cette initiative se fait également en interaction avec le projet Seabed2030 (seabed2030.org).
TV_KINFNC 2024 cruise,Pourquoi pas ? R/V
Creators: name: Benoit, LOUBRIEU
name: Javier, ESCARTIN
Publisher: name: Sismer
Year: 2024

description: Initiative « Valorisation bathymétrique des transits de la flotte océanographique » L'acquisition de données bathymétriques sur ce transit est à l'initiative d'un groupe de géologues et géophysiciens, en concertation avec la Flotte Océanographique Française. L'objectif global de cette initiative est de généraliser l'acquisition de données de sondeurs multifaisceaux sur les transits des navires de la flotte, en vue de a) compléter les couvertures bathymétriques existantes à moyenne et haute résolution et contribuer à la cartographie bathymétrique globale des océans, b) établir un protocole d'acquisition et traitement des données des transits valorisées, et c) faciliter les travaux de recherche à travers le partage publique des données acquises lors de ces transits. Les données sont destinées à un usage de cartographie moyenne résolution (modèle numérique de terrain au pas de grille d'une centaine de mètres). L'acquisition de données se fait dans un mode contraint : la vitesse du navire est celle fixée par le transit, sans ajustement vis-à-vis de la qualité des données ou leur résolution; le sondeur multifaisceaux est placé dans un mode automatique. L'acquisition n'est pas nécessairement suivie en continu par un opérateur spécialisé; les profils de célérité utilisés pour l'acquisition des données et le calcul des sondes sont établis à partir de tables globales, sans mesure in-situ de température et salinité lors de l'acquisition (de type sondes de température).Les données sont pré-traitées et validées et sont destinées à être mise à disposition à court terme dans la base de données des navires océanographiques Sismer. L'acquisition est limitée aux eaux internationales, pour lesquelles aucune demande d'autorisation n'est nécessaire. Cette initiative se fait également en interaction avec le projet Seabed2030.
Reminiscences of Lyman L. Lemnitzer, 1972
Publisher: name: Columbia University
Year: 2020
Subjects: Veterans
World War, 1939-1945
Korean War, 1950-1953
Space flight

description: World War II experiences; Deputy Chief of Staff for plans and research, Department of the Army, 1952-55; United Nations, Commander-in-Chief, Korea; Army vice chief of staff, 1957-59; Chief of Staff, 1959-60; arguments regarding Jupiter missile, space program and formation of National Air and Space Administration (NASA)
Holographic c-theorem and Born-Infeld Gravity Theories
Creators: name: Alkac, Gokhan
name: Tekin, Bayram
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The requirement of the existence of a holographic c-function for higher derivative theories is a very restrictive one and hence most theories do not possess this property. Here, we show that, when some of the parameters are fixed, the $D\geq3$ Born-Infeld gravity theories admit a holographic c-function. We work out the details of the $D=3$ theory with no free parameters, which is a non-minimal Born-Infeld type extension of new massive gravity. Moreover, we show that these theories generate an infinite number of higher derivative models admitting a c-function in a suitable expansion and therefore they can be studied at any truncated order.
description: 18 pages, minor corrections, version accepted for publication in Physical Review D
title: ADCO, Cartulaire de Saint-Étienne de Dijon (XIVe siècle), Cart. 24 (G 137), 31 folios, f. 0048
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2011
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: Corpus Burgundiae Medii Aevi

description: Cartulaire de Saint-Étienne de Dijon (XIVe siècle), Archives départementales de la Côte-d'Or, Cart. 24 (G 137), 31 folios, f. 0048, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Saint-Étienne de Dijon (XIVe siècle), Archives départementales de la Côte-d'Or, Cart. 24 (G 137), 31 folios, f. 0048, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Reminiscences of Lyman Lloyd Bryson : 1951
Publisher: name: Columbia University
Year: 2020
Subjects: Journalists
Educators
Radio broadcasting
Broadcast journalism
Radio supplies industry

description: Family background and education; journalism instructor, University of Michigan; Army, 1917; American Red Cross; lecturer, University of California, 1925; director, San Diego Museum; Teachers College; radio commentator from 1927; educational broadcasts for CBS: networks and local stations; radio and fiscal matters; views on broadcasting; impressions of acadmic and broadcasting personalities
Leptocarpus simplex R. Br.
Creators: name: Jarvis, Charlie
Publisher: name: Linnaean Society of London in association with the Natural History Museum
Year: 2007
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Poales
Restionaceae
Leptocarpus
Leptocarpus simplex

description: Restio simplex Linnaeus, Systema Vegetabilium, ed. 13: 738. 1774.
RCN: 7395.
Type not designated.
Original material: none traced.
Current name: Leptocarpus simplex (L.) R. Br. (Restionaceae).
description: Published as part of Jarvis, Charlie, 2007, Chapter 7: Linnaean Plant Names and their Types (part R), pp. 785-805 in Order out of Chaos. Linnaean Plant Types and their Types, London :Linnaean Society of London in association with the Natural History Museum on page 790, DOI: 10.5281/zenodo.291971
Armus dual roles in autophagy and E-cadherin degradation: distinct partners, regulation and implications for cancer patients
Creators: name: Mohd Naim, Noor Faizah
Publisher: name: Imperial College London
Year: 2015

description: Cancer is one of the leading causes of mortality worldwide. Invasion, metastasis and apoptotic evasion are cancer hallmarks. Tumour cell metastasis requires loss of E-cadherin cell-cell adhesion receptor. Apoptotic evasion can be mediated by up-regulation of autophagy, which maintains cellular energy during metabolic stress in cancer cells. Armus is a TBC/RabGAP protein that regulates both E-cadherin degradation and autophagy by controlling lysosome fusion with late vesicular compartments or autophagosomes. Understanding Armus function in these degradative processes during tumourigenesis may lead to combinatorial inhibition of oncogenic pathways and novel therapeutic targets. Here I address: (i) whether Armus participates in E-cadherin deregulation downstream of oncogenes, (ii) potential mechanisms through which Armus can switch between its function at junctions and autophagosomes and (iii) potential strategies to inhibit Armus intracellular localisation. I found that Armus is involved in Src and H-Ras disruption of E-cadherin junctions in keratinocytes. Armus binds to α-catenin at junctions, while at autophagosomes Armus interacts with autophagy marker, LC3. Incubation with Armus peptides containing LC3-interacting motifs partially blocks Armus function in autophagy. Mutation of the specific residues mediating α-catenin association reduces Armus localisation at cell-cell contacts. The close juxtaposition of LC3 and α-catenin binding at PH domain at Armus N-terminus may suggest additional roles. Armus N-terminus and RabGAP domain interact directly, and residue K480 is critical for binding. This intramolecular interaction may form a closed conformation, and Armus activation may require the release of this auto-inhibition. It is tempting to suggest that protein interactions at the PH domain such as LC3 and α-catenin may modulate Armus auto-inhibition. Alternatively, the phosphoinositide repertoire interacting with the PH domain may contribute to Armus intracellular distribution and activation. Further insights into Armus activation may provide greater understanding of its function in distinct cellular events with implications for tumourigenesis.
Early Evolution of Disk Galaxies : Formation of Bulges in Clumpy Young Galactic Disks
Creators: name: Noguchi, Masafumi
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: A new idea is proposed for the origin of bulges in spiral galaxies. Numerical simulations for the protogalactic collapse suggest strongly that galactic bulges have been assembled from massive clumps formed in the galactic disks in their early evolutionary phase. These clumps result from the gravitational instability of the gas-rich disks of young galaxies. Those massive clumps, individual masses of which can be as large as one billion solar masses, are able to spiral toward the galactic center owing to dynamical frictions within a few Gyr. Inward transport of disk matter by this process leads to the formation of a galactic bulge. A simple analytical model has been constructed, in which the clumpy evolution of a disk galaxy is controlled by two parameters; the timescale with which the primordial gas in the halo accretes onto the disk plane (i.e., collapse timescale) and the mass fraction of the primordial gas relative to the galaxy total mass. Under plausible assumptions for the variation of these parameters among spiral galaxies, the clumpy evolution model can explain the observed trend that the bulge-to-disk ratio increases as the total mass or the internal density of the galaxy increases. This success suggests that the clumpy evolution of the galactic disk constitutes an important ingredient of the disk galaxy evolution. Star formation in primeval disk galaxies takes place mostly in the clumps. Resulting knotty appearance of these systems may explain the peculiar morphology observed in a number of high-redshift galaxies.
description: 45 pages, 8 GIF figures, 17 PS figures, submitted to ApJ, PS versions of the text and all the figures can be taken from http://www.astr.tohoku.ac.jp/~noguchi/ftp/bulge-paper/
CFD modeling of void distribution in two-phase flows
Creators: name: Majumder, Golam Qutube Rabbani
Publisher: name: Imperial College London
Year: 2016

description: Cross-flow boiling on tube/tube-bundles commonly found in horizontal steam generators, kettle reboilers, etc. presents substantial complexity due to the local two-phase flow structures in the presence of phase-change heat transfer, but a modelling capability would be of considerable practical use. To use component-scale ensemble-averaged Eulerian-Eulerian CFD multiple additional closure models are required to define the interactions between bubble-liquid and bubble–bubble interfaces, and the choice of these models inevitably affects the predictions. This thesis reports investigations into these closure models, focusing mainly on the interfacial forces for modeling two-phase adiabatic and subcooled boiling flows, and the effects that they have upon the predictions of the flow, with the objective of attempting to identify so far as possible a "best combination". Detailed CFD investigations on adiabatic and boiling upward two-phase flows in a simple vertical pipe geometry, using the ensemble average Eulerian-Eulerian two-fluid framework of the commercial CFD code STAR-CCM+, with various interfacial force models, are reported. This is done for both adiabatic and subcooled boiling flows. One of the main findings of these studies was the model inadequacies associated with the non-drag interfacial forces that are primarily responsible for the lateral void distributions. Among the interfacial force models investigated for adiabatic cases, the use of the Ishii and Zuber (1979) drag coefficient, the Behzadi et al. (2004) lift coefficient and the Antal et al. (1991) wall lubrication force model combination gives the best predictions for all the primitive variables considered. However, the need for a more appropriate model for the lift force coefficient, along with a matched/paired model for the wall lift/lubrication force, is identified. For the subcooled boiling investigation, a negative lift coefficient (-0.1) in conjunction with the default turbulent dispersion and wall lubrication force models predicted a reasonably accurate axial void distribution, as well as an acceptable velocity profile for both phases, and this is identified as the “best combination”. In addition, many other shortcomings regarding the closures related to the two-fluid framework have been identified and are discussed. Finally, the ‘best combination’ of models has been used successfully to simulate the boiling heat transfer on a single tube under cross-flow, which is a novel application of the Eulerian-Eulerian two-fluid approach in conjunction with the WHFP approach on such flow geometry.
Rhamnus alaternus Linnaeus, 1753, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1753
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Rosales
Rhamnaceae
Rhamnus
Rhamnus alaternus

description: Rhamnus alaternus, spec. nov.
 4. Rhamnus inermis, floribus dioicis, stigmate triplici. Vir. cliff. 19. Hort. ups. 47. Sauv. monsp.95.
 Rhamnus inermis, floribus polygamis, stigmate triplici, foliis serratis. Hort. cliff. 70. Roy. lugdb. 225.
 Phylica elatior. Bauh. pin. 477.
 Phylica humilior. Bauh. pin. 477.
 Alaternus. 1. 2. Clus. hist. 1. p. 50.
 Habitat in Europa australi. ♄    * * * Aculeati.
description: Published as part of Linnaeus, Carolus, 1753, Species plantarum: exhibentes plantas rite cognitas, ad genera relatas, cum differentiis specificis, nominibus trivialibus, synonymis selectis, locis natalibus, secundum systema sexuale digestas, Stockholm :Laurentius Salvius on pages 193-194, DOI: 10.5281/zenodo.3931989
TV_FNCBES 2024 cruise,Pourquoi pas ? R/V
Creators: name: Benoit, LOUBRIEU
name: Javier, ESCARTIN
Publisher: name: Sismer
Year: 2024

description: Initiative « Valorisation bathymétrique des transits de la flotte océanographique » L'acquisition de données bathymétriques sur ce transit est à l'initiative d'un groupe de géologues et géophysiciens, en concertation avec la Flotte Océanographique Française. L'objectif global de cette initiative est de généraliser l'acquisition de données de sondeurs multifaisceaux sur les transits des navires de la flotte, en vue de a) compléter les couvertures bathymétriques existantes à moyenne et haute résolution et contribuer à la cartographie bathymétrique globale des océans, b) établir un protocole d'acquisition et traitement des données des transits valorisées, et c) faciliter les travaux de recherche à travers le partage publique des données acquises lors de ces transits. Les données sont destinées à un usage de cartographie moyenne résolution (modèle numérique de terrain au pas de grille d'une centaine de mètres). L'acquisition de données se fait dans un mode contraint : la vitesse du navire est celle fixée par le transit, sans ajustement vis-à-vis de la qualité des données ou leur résolution; le sondeur multifaisceaux est placé dans un mode automatique. L'acquisition n'est pas nécessairement suivie en continu par un opérateur spécialisé; les profils de célérité utilisés pour l'acquisition des données et le calcul des sondes sont établis à partir de tables globales, sans mesure in-situ de température et salinité lors de l'acquisition (de type sondes de température).Les données sont pré-traitées et validées et sont destinées à être mise à disposition à court terme dans la base de données des navires océanographiques Sismer. L'acquisition est limitée aux eaux internationales, pour lesquelles aucune demande d'autorisation n'est nécessaire. Cette initiative se fait également en interaction avec le projet Seabed2030.
TV_HORBES 2024 cruise,L'Atalante R/V
Creators: name: Benoit, LOUBRIEU
name: Javier, ESCARTIN
Publisher: name: Sismer
Year: 2024

description: Initiative « Valorisation bathymétrique des transits de la flotte océanographique » L'acquisition de données bathymétriques sur ce transit est à l'initiative d'un groupe de géologues et géophysiciens, en concertation avec la Flotte Océanographique Française. L'objectif global de cette initiative est de généraliser l'acquisition de données de sondeurs multifaisceaux sur les transits des navires de la flotte, en vue de a) compléter les couvertures bathymétriques existantes à moyenne et haute résolution et contribuer à la cartographie bathymétrique globale des océans, b) établir un protocole d'acquisition et traitement des données des transits valorisées, et c) faciliter les travaux de recherche à travers le partage publique des données acquises lors de ces transits. Les données sont destinées à un usage de cartographie moyenne résolution (modèle numérique de terrain au pas de grille d'une centaine de mètres). L'acquisition de données se fait dans un mode contraint : la vitesse du navire est celle fixée par le transit, sans ajustement vis-à-vis de la qualité des données ou leur résolution; le sondeur multifaisceaux est placé dans un mode automatique. L'acquisition n'est pas nécessairement suivie en continu par un opérateur spécialisé; les profils de célérité utilisés pour l'acquisition des données et le calcul des sondes sont établis à partir de tables globales, sans mesure in-situ de température et salinité lors de l'acquisition (de type sondes de température).Les données sont pré-traitées et validées et sont destinées à être mise à disposition à court terme dans la base de données des navires océanographiques Sismer. L'acquisition est limitée aux eaux internationales, pour lesquelles aucune demande d'autorisation n'est nécessaire. Cette initiative se fait également en interaction avec le projet Seabed2030.
Epigenetic control of the post-bariatric phenotype: the role of microRNAs
Creators: name: Alkandari, Abdullah
Publisher: name: Imperial College London
Year: 2015

description: The rising obesity pandemic and the concomitant rise in its co-morbidities are leading causes of global morbidity and mortality. Bariatric surgery is a form of gastrointestinal surgery that leads to sustained weight loss, diabetes resolution, reduction in cancer risk and other improvements in health. MicroRNAs are a family of small, endogenous, non-coding RNAs that regulate gene expression at the post-transcriptional level. MicroRNAs control expression of over half the human transcriptome and are involved in processes fundamental to both normal physiology and disease, including obesity and diabetes. This study hypothesizes that microRNAs are biomarkers for health improvements following bariatric surgery. Using quantitative PCR, a microRNA baseline was established in the serum and urine of an obese human population and increases in three anti-fibrotic microRNAs were found in urine following bariatric surgery. Circulating microRNA profiles were characterised in Roux-en-Y gastric bypass patients preoperatively and at 5 timepoints postoperatively. Roux-en-Y gastric bypass significantly altered circulating microRNA profiles in a time dependent manner. Relative to preoperative levels, of the 159 circulating microRNAs assayed 2 were significantly deregulated 1 month postoperatively, 5 were deregulated at 3 months, 10 at 6 months, 28 at 9 months and 31 at 12 months. Target prediction and pathway analysis revealed that these differentiated microRNAs regulate biological pathways that are involved in obesity and that microRNAs may contribute to the development of the beneficial post-bariatric phenotype. Both circulating and urinary post-bariatric microRNA levels correlated with measured clinical biomarkers such as BMI and blood glucose. These results indicate that bariatric operations fundamentally alter microRNA expression both in urine and in circulation and suggest that microRNAs represent not only potentially novel biomarkers for improvements in health following surgery, but are possible biological effectors that contribute to the mechanisms behind bariatric surgery. MicroRNA expression profiles could potentially be used to monitor operative outcomes and understanding the role of these differentially expressed microRNAs could shed light behind the mechanism by which bariatric surgery improves health.
TV_BESZLO 2024 cruise,L'Atalante R/V
Creators: name: Benoit, LOUBRIEU
name: Javier, ESCARTIN
Publisher: name: Sismer
Year: 2024

description: Initiative « Valorisation bathymétrique des transits de la flotte océanographique » L'acquisition de données bathymétriques sur ce transit est à l'initiative d'un groupe de géologues et géophysiciens , en concertation avec la Flotte Océanographique Française. L'objectif global de cette initiative est de généraliser l'acquisition de données de sondeurs multifaisceaux sur les transits des navires de la flotte, en vue de a) compléter les couvertures bathymétriques existantes à moyenne et haute résolution et contribuer à la cartographie bathymétrique globale des océans, b) établir un protocole d'acquisition et traitement des données des transits valorisées, et c) faciliter les travaux de recherche à travers le partage publique des données acquises lors de ces transits. Les données sont destinées à un usage de cartographie moyenne résolution (modèle numérique de terrain au pas de grille d'une centaine de mètres). L'acquisition de données se fait dans un mode contraint : - la vitesse du navire est celle fixée par le transit, sans ajustement vis-à-vis de la qualité des données ou leur résolution. - le sondeur multifaisceaux est placé dans un mode automatique. L'acquisition n'est pas nécessairement suivie en continu par un opérateur spécialisé. - les profils de célérité utilisés pour l'acquisition des données et le calcul des sondes sont établis à partir de tables globales, sans mesure in-situ de température et salinité lors de l'acquisition (de type sondes de température). Les données sont pré-traitées et validées et sont destinées à être mise à disposition à court terme dans la base de données des navires océanographiques Sismer. L'acquisition est limitée aux eaux internationales, pour lesquelles aucune demande d'autorisation n'est nécessaire. Cette initiative se fait également en interaction avec le projet Seabed2030.
Evaluation and improvement of QSAR predictions of skin sensitization for pesticides
Creators: name: C. Braeuning
name: A. Braeuning
name: H. Mielke
name: A. Holzwarth
name: M. Peiser
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: In vivo skin sensitization assays have to be provided by applicants to the competent authorities in the European Union for the approval of active substances (AS) in pesticides. This study aimed to test the practicability of in silico predictions for AS by freely available (Q)SAR tools to evaluate their use as a time- and cost-effective alternative to animal testing in the context of the 3R concept. Predictions of skin sensitization for 48 selected sensitizing and non-sensitizing AS by the software programs CAESAR, Toxtree, OECD (Q)SAR Toolbox, CASE Ultra, Leadscope and SciQSAR were collected and compared. Different data evaluation methodologies (score definition, mean, weighted mean, threshold score definition) were applied to optimize the predictions. The calculation methods were internally cross-validated and further validated with an additional validation set of 80 AS. Although the presented calculation methodologies are not suitable as a stand-alone method, this study has shown weaknesses and strengths of some prominent (Q)SAR programs and diverse combinatorial options in the prediction of skin sensitization by pesticidal AS. The present study will help to foster discussions on in silico alternatives to animal testing in the pesticide area.
Reminiscences of Malcolm Ames MacIntyre, 1981
Publisher: name: Columbia University
Year: 2021
Subjects: Government executives--United States
Lawyers
Practice of law
Law partnership
Airlines

description: Associate, Sullivan & Cromwell, 1934-42; Air Transport Command, 1942-46; partner in law firm of Douglas Proctor MacIntyre & Gates, 1946-48; Debevoise Plimpton Lyons & Gates, 1948-57: decision to join, general counsel to American Airlines; Undersecretary of Air Force, 1957-59: U-2 incident; President of Eastern Airlines, 1959-63: innovation of New York City-Washington DC shuttle service; member, New York State Law Revision Commision, 1972-76; differences between lawyers and business executives
Ensuring the resilience of wireless sensor networks to malicious data injections through measurements inspection
Creators: name: Illiano, Vittorio Paolo
Publisher: name: Imperial College London
Year: 2017

description: Malicious data injections pose a severe threat to the systems based on \emph{Wireless Sensor Networks} (WSNs) since they give the attacker control over the measurements, and on the system's status and response in turn. Malicious measurements are particularly threatening when used to spoof or mask events of interest, thus eliciting or preventing desirable responses. Spoofing and masking attacks are particularly difficult to detect since they depict plausible behaviours, especially if multiple sensors have been compromised and \emph{collude} to inject a coherent set of malicious measurements. Previous work has tackled the problem through \emph{measurements inspection}, which analyses the inter-measurements correlations induced by the physical phenomena. However, these techniques consider simplistic attacks and are not robust to collusion. Moreover, they assume highly predictable patterns in the measurements distribution, which are invalidated by the unpredictability of events. We design a set of techniques that effectively \emph{detect} malicious data injections in the presence of sophisticated collusion strategies, when one or more events manifest. Moreover, we build a methodology to \emph{characterise} the likely compromised sensors. We also design \emph{diagnosis} criteria that allow us to distinguish anomalies arising from malicious interference and faults. In contrast with previous work, we test the robustness of our methodology with automated and sophisticated attacks, where the attacker aims to evade detection. We conclude that our approach outperforms state-of-the-art approaches. Moreover, we estimate quantitatively the WSN degree of resilience and provide a methodology to give a WSN owner an assured degree of resilience by automatically designing the WSN deployment. To deal also with the extreme scenario where the attacker has compromised most of the WSN, we propose a combination with \emph{software attestation techniques}, which are more reliable when malicious data is originated by a compromised software, but also more expensive, and achieve an excellent trade-off between cost and resilience.