cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Impact of the AMPK gamma2 R302Q Mutation on Human Skeletal Muscle Metabolism
Creators: name: Moffat, Cynthia
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Chemistry, Biochemistry.

description: AMP-activated protein kinase, AMPK, is a heterotrimeric protein complex comprised of an alpha catalytic, and of beta and gamma regulatory subunits. It is widely conserved across most organisms and is commonly referred to as the master regulator of cellular metabolism. By responding to increases in the AMP:ATP ratio, AMPK promotes ATP producing catabolic pathways, while simultaneously inhibiting ATP consuming anabolic pathways. Naturally occurring mutations in AMPK exist in various organisms and these can have a severe impact on fuel storage and metabolism. One such mutation in humans is the R302Q mutation in the gamma2 subunit; the outcome is accelerated glycogen production and impaired electrical conductance within the heart, resulting in Wolff-Parkinson White (WPW) syndrome. The impact of this rare mutation on AMPK activity is not well understood. By examining skeletal muscle samples from affected patients from the Ottawa region, we strove to determine the impact of the R302Q mutation on AMPK activity, and skeletal muscle metabolism. Skeletal muscle biopsies were utilized for histological analyses and cell culture determinations of fuel storage and AMPK activity. Trends for decreased triglyceride storage and increased glycogen storage, as well as impaired basal and AMP-stimulated AMPK activity were observed in the affected patient populations. Corollary work done in an adenoviral infected C2C12 muscle cell line expressing human gamma2 WT or the R302Q variant yielded no difference between groups in fuel storage or protein phosphorylation due to limitations (infection efficiency) of this model.
Challenges faced by multidisplinary new investigators on addressing grand challenges in global health
Creators: name: Logie, Carmen
name: Dimaras, Helen
name: Fortin, Anny
name: Ramón-García, Santiago
Publisher: name: BioMed Central
Year: 2015

description: Background. The grand challenges approach aims to spark innovative and transformative strategies to overcome barriers to significant global health issues. Grand Challenges Canada endorses an ‘Integrated Innovation™’ approach that focuses on the intersection of scientific/technological, social and business innovation. In this article we explore themes emerging from a dialogue between the authors, who are multidisciplinary recipients of the ‘Rising Stars in Global Health’ award from Grand Challenges Canada, regarding benefits of engaging in integrated innovation research, and recommendations for how this approach may develop in the future. Discussion Our dialogue followed a semi-structured interview format that addressed three topics: 1) reflections on applying an Integrated Innovation™ approach for global health; 2) thoughts on participation in the Grand Challenges 2012 meeting; and 3) authors’ visions of Grand Challenges Canada and the Grand Challenge movement towards 2020. The dialogue was transcribed verbatim and we used thematic analysis techniques to identify, analyze and report themes in the data. Benefits of working using the Grand Challenges approach centered on two themes: a) the potential for scientific breakthrough and b) building interdisciplinary collaborations and a community of scholars. Challenges and opportunities for Grand Challenges in moving forward included: a) capacity building, particularly regarding Integrated Innovation™ and scale-up planning; b) interdisciplinary and international mentorship for new investigators; and c) potential for future commercialization. Conclusions Our discussion highlighted that Integrated Innovation™ offers the opportunity to develop new theories, methods and approaches to global health while simultaneously fostering a collaborative spirit grounded in international, interdisciplinary collaborations. However, the arguable over-emphasis on corporatization poses a major challenge for new investigators. We propose a more balanced way forward that can harness technology to foster mentorship across time and space to support the development of such skills and ideas among new investigators.
Victims' rights organizations and the Daubney Committee: An examination of claims and their incorporation.
Creators: name: Lonsdale, Raymond.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Political Science, General.

description: The purpose of this thesis is to assess the response of the Daubney Committee to the claims of five victims' rights organizations. Victims' rights organizations claim that the criminal justice system consistently fails to keep dangerous offenders incarcerated and drinking drivers off the road, resulting in considerable threat to the public. Chapter 2 presents a number of theories that have dominated the notion of social problems and claims making in the last fifty years. Of particular interest is the notion of "claims-making" as its focuses on explaining a social problem as a series of claims made by a person or a group about an issue. Chapter 3 offers a brief historical account of the establishment of several victims' rights organizations. Once established, victims' groups proceeded throughout the 1980s making claims and lobbying for fairer treatment. Chapters 4 and 5 concern the primary claims-making activities of the five victims' rights organizations in this study, and focuses on how these claims-makers framed issues in order to attract attention. Chapters 6 and 7 explore whether the Daubney Committee responded to claims-making by these five groups. Chapter 7 introduces Bill C-36. This legislation is important as it embodies the spirit of the Daubney Committee. It will be argued, that while the Daubney Committee made a concerted effort to respond to some of the concerns expressed by victims' rights organizations only those concerns seen as reparative in nature were seriously considered. Chapter 8 illustrates this point, listing the expectations of the victims' group and the response of the Daubney Committee in a table format. In Chapter 9, the thesis concludes by suggesting that the creation of an amendment to the Canadian constitution would be a necessary step in ensuring fair and equitable treatment for victims of crime. (Abstract shortened by UMI.)
Barriers and facilitators for implementation of electronic consultations (eConsult) to enhance specialist access to care: a scoping review protocol.
Creators: name: Osman, Mohamed A.; Schick-Makaroff, Kara; Thompson, Stephanie; Featherstone, Robin; Bialy, Liza; Kurzawa, Julia; Okpechi, Ikechi G.; Habib, Syed; Shojai, Soroush; Jindal, Kailash; Klarenbach, Scott; Bello, Aminu K.
Publisher: name: University of Alberta Libraries
Year: 2018

Abstract
Convergence targeted: policy battle ahead
Creators: name: Given, Jock
Publisher: name: Swinburne
Year: 2024

description: The final report of the Convergence Review recommends fundamental changes to the regulation of media enterprises in Australia. Instead of directing most of the regularion at TV and radio licenseses the Review proposes to regulate 'content service enterprises.' The big questions now are whether or not a vulnerable minority government a year away from an election will endorse the plan; which organisations might be covered by the definition of 'content service enterprises'; and how the complex transition from the current rules to any new ones might be managed. A government wanting 'to examine the operation of media and communications regulation in Australia and assess its effectiveness in achieving appropriate policy objectives' had many places to focus. It could have concentrated on the 'socialisation' of media through applications like Facebook; the proliferation of media channels and the fragmentation of audience choices; or the growing power of media users.
title: 03_0755
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Selective multistage detection algorithm in flat Rayleigh fading channel
Creators: name: Pan, Li
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Engineering, Electronics and Electrical.

description: Selective multistage detection algorithm applied in AWGN channel is first proposed in [1]. It is shown that the BER performance of this detector is slightly better than conventional multistage detector if the threshold level is properly selected. At the same time, the number of computations performed by the receiver is greatly reduced since MAI cancellation is only applied to those decision variables whose magnitudes are less than a threshold value. In this thesis, we will investigate the performance of selective multistage detection algorithm for the frequency nonselective Rayleigh fading channel which is more common in the wireless communications. The performance will be determined by computer simulation. First, we will consider the performance of selective multistage detection and nonselective multistage detection when the receiver perfectly estimates the channel gains of all of the users. Then we will employ pilots based estimation with optimum interpolator to estimate the channel gains. Receiver will make use of the estimated channel gain to detect the data of every user. Finally we will compare the performances of selective and nonselective multistage detectors under the imperfect channel estimation case. We also propose a modified selective multistage algorithm in order to improve the performance of selective multistage detector further without a large increase in the amount of computation. It applies partial MAI cancellation, instead of full cancellation, to those decision variables whose magnitudes are less than a threshold value. By employing the modified selective multistage algorithm, we will achieve the performance that is close to that of conventional multistage with perfect channel estimation.
La réflexion et les communautés de pratique pour faciliter l'apprentissage par expérience d'entraîneurs d'un club de karaté et d'un programme de sport scolaire
Creators: name: Lemyre, François
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Education, Physical.
subject: Education, Teacher Training.
subject: Recreation.

description: Considérant (a) que les programmes de formation formels semblent avoir un impact mitigé sur le parcours d'apprentissage des entraîneurs, (b) que ce ne sont pas tous les entraîneurs qui réfléchissent sur leurs actions, (c) que les entraîneurs échangent très peu leur savoir entre eux et (d) qu'il peut être avantageux de combiner des types d'apprentissage individuel et collectif (Raelin, 2000), le but général de la thèse était de documenter deux initiatives visant à favoriser, chez les entraîneurs, l'apprentissage au rôle d'entraîneur. Ces initiatives étaient guidées par les principes du paradigme de recherche participatoire (Heron et Reason, 1997). La première étude a été réalisee avec des entraîneurs de karaté dans un club civil et le chercheur assumait un rôle de pleine participation. La seconde étude s'est déroulée avec des entraîneurs de volley-ball et de basket-ball d'une même éccole secondaire et le chercheur était engagé dans une participation partielle. Dans une perspective de formation d'entraîneurs à partir de leur expérience, nos résultats ont fait ressortir que les principaux défis des chercheurs consistent à (a) négocier leur rôle/implication pour optimiser les apprentissages, (b) aider les entraîneurs à devenir des praticiens réflexifs, (c) faciliter la construction de savoir à travers des activités pouvant inciter les entraîneurs à créer leur CdP et (d) identifier clairement la réalité du milieu. Nos résultats indiquent également que des approches telles l'objectivation clinique, l'Action Learning et l'Action Science peuvent stimuler la construction de savoir dans la mesure où les entraîneurs peuvent surpasser les principales barrières au processus d'apprentissage que sont le manque de temps et l'attribution d'un certain pouvoir à l'intérieur du groupe.
Brachylia fibigeri Yakovlev, 2019, sp. nov.
Creators: name: Yakovlev, Roman V.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Cossidae
Brachylia
Brachylia fibigeri

description: Brachylia fibigeri sp. nov. (Figure 1: A−B)
 Material. Holotype: male, Yemen, Prov. Sana’a, 13º48′N; 44º10′E, Mahal al Houmeira, 5 km NON Qa’idah, 1840−1900 m, 6.iii.2000, leg. F. Aulombard, M. Fibiger, H. Hacker & H.P. Schreier (Museum Witt, GenPr Heterocera: 32.733).
 Name. The new species is named after its collector, the prominent entomologist, specialist in Noctuoidea, Michael Fibiger (1945−2011).
 Diagnosis. The new species is mostly close to the East-African species Brachylia reussi (Strand, 1913) (Type locality: Morogoro in D.O. Africa [Tanzania]) widely spread in Kenya and Tanzania, from which it differs by the following characters:
- the reticulated pattern on the fore wing
- the absence of the brown patch on the fore wing discal area
- the absence of small prongs on the abdominal edge of the transtilla process
- the longer, sharpened transtilla processes.
 Description. Fore wing length 17 mm. Wing relatively narrow, apically triangle. Antenna bipectinate, crest processes twice longer than antenna rod diameter. Tegulae and patagia grey. Fore wing grey with thin undulated transverse lines, more dense in discal area, a series of frequent black strokes along costal edge, basal area darkened, fringe pale grey unicolorous. Hind wing pale grey with poorly expressed pattern of grey thin undulated lines, fringe pale grey unicolorous.
Male genitalia. Uncus triangle, relatively short, slightly tapered apically; gnathos arms of medium length, thick; gnathos robust, densely covered with short spikes; valve apically semicircular, apex membranous, on costal edge in place of transition of sclerotized part into membranous one there is a robust double crest with two strongly sclerotized ribs on inner valve surface; transtilla process basally thick, gradually narrowing apically, uncinate, strongly curved in medium third; juxta small, triangle, apex directed abdominally, two lateral processes basally thin and gradually widening to apices; saccus semicircular, robust; phallus equal to length of valve, curved at border of proximal and medium thirds, apex obliquely cut, vesica aperture in dorso-apical position, equal to 2/3 of phallus in length, vesica without cornuti.
Female unknown.
 Distribution. Known only from Yemen (Province Sana’a).
description: Published as part of Yakovlev, Roman V., 2019, Two new species of Cossinae (Lepidoptera, Cossidae) from Arabian Peninsula, pp. 42-45 in Ecologica Montenegrina 21 on page 43, DOI: 10.37828/em.2019.21.4, http://zenodo.org/record/13356289
Osteoarthritis incidence and trends in administrative health records from British Columbia, Canada
Creators: name: Rahman, Md Mushfiqur
name: Cibere, Jolanda, 1962-
name: Goldsmith, Charlie H.
name: Anis, Aslam H. (Aslam Hayat), 1959-
name: Kopeć, Jacek A.
Publisher: name: The University of British Columbia
Year: 2020

description: Objectives Our objectives were to calculate the incidence rates of osteoarthritis (OA) and to describe the changes in incidence using 18 years of administrative health records. Methods We analyzed visits to health professionals and hospital admission records in a random sample (n = 640,000) from British Columbia (BC), Canada from 1991/92 through 2008/09. OA was defined in two ways: Def1) at least one physician diagnosis or one hospital admission; and Def2) at least two physician diagnoses in two years or one hospital admission. Crude and age-standardized rates were calculated, and the annual relative changes were estimated from the Poisson regression models. Results In 2008/09, the overall crude incidence rate (95% CI) of OA using Def1 was 14.6 (14.0-14.8) (12.5 (12.0-13.0) among men and 16.3 (15.8-16.8) among women) per 1000 person years. The rates were lower by about 44% under Def2. For the period 2000/01-2008/09, crude incidence rates based on Def1 varied from 11.8-14.2 per 1000 person years for men and from 15.7-18.5 for women. Annually on average, crude rates rose by about 2.5-3.3% for both men and women. The age-adjusted rates increased by 0.6-0.8% among men and showed no trend among women. Conclusions Our study generated updated incidence rates of administrative OA for the province of British Columbia. Physician diagnosed overall incidence rates of OA varied with the case definitions used, however trends were similar in both case definitions. Age-adjusted rates among men increased slightly during the period 2000/01-2008/09. These findings have implications for projecting future prevalence and costs of OA.
Gene and protein expression profiling of a presymptomatic type III spinal muscular atrophy mouse model
Creators: name: Balabanian, Sylvia
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Biology, Neuroscience.

description: In order to determine the molecular events leading up to motor neuron degeneration in SMA this study profiled the changes at the mRNA and protein levels in spinal cords of Smn+/- mice with those of Smn+/- littermates. The Smn+/- mice show 50% motor neuron loss by 6 months of age and are used as a model for mild SMA in humans. We have isolated RNA from spinal cords of 5-week-old mice in order to perform representational difference analysis (RDA) and microarray analysis using Affymetrix MOE430 arrays. Subtle but reproducible changes occur in the transcriptome of SMA mice. Genes involved in RNA metabolism, apoptosis regulation and transcriptional regulation were shown to be the most affected in the Smn +/- mice. These changes in expression were characterized by semi-quantitative RT-PCR and Western blot analysis at various timepoints. The differences in protein levels in 5-week-old Smn +/- and Smn+/+ spinal cords were examined using apoptosis and kinase protein screens from Kinetworks Bioinformatics. Results demonstrated similar protein expression levels in the Smn +/- and Smn+/+ samples. Although the signaling pathways and apoptotic protein levels do not seem to be significantly altered in the SMA mouse spinal cord at the 5-week presymptomatic stage we believe that the cells present the first signs of the apoptotic process indicating that they are responding to the stress of Smn depletion.
METHODOLOGY TO CHARACTERIZE MULTIMODES INTERFEROMETER
Creators: name: Feugnet, Gilles
name: Evanno, Léonie
Publisher: name: Zenodo
Year: 2024
Subjects: multimodes interferometer
characterization
building blocks

description: This document aims at summarizing the characterization method that was developed in ELENA project. In these projects, different partners characterize the same building blocks and they had to define common characterizations and analysis methods.

 

The information, documentation and figures in this document are written by the ELENA consortium under EC grant agreement no. 101016138 and do not necessarily reflect the views of the European Commission. The European Commission is not liable for any use that may be made of the information contained herein.
Keeping up with the feds: The provincial response to Canada's Species at Risk Act
Creators: name: Hofmann, Catherine
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Law.
subject: Political Science, General.
subject: Environmental Sciences.

description: This thesis examines how the threat of federal intrusion into provincial jurisdiction over natural resource management which accompanied the development and passage of Canada's Species at Risk Act (SARA) has impacted provincial legislation and policies aimed at protecting endangered species. SARA's safety net provisions constitute the mechanism by which Ottawa may act unilaterally to provide effective protection for species at risk and their habitats where a provincial or territorial government fails to do so. The federal government's historical reluctance to use similar clauses in other environmental legislation suggests that the true value of the safety net is the degree to which threat alone is sufficient to motivate provincial action. A review of the statutory and policy changes undertaken by the provinces reveals the extent to which the development of SARA and its safety net has spurred provincial governments to provide more effective protection for endangered species.
Evolution of gene structure in the conifer Picea glauca: a comparative analysis of the impact of intron size
Creators: name: Stival Sena, Juliana
name: Giguère, Isabelle
name: Boyle, Brian
name: Rigault, Philippe
name: Birol, Inanc
name: Zuccolo, Andrea
name: Ritland, Kermit
name: Ritland, Carol
name: Bohlmann, Jörg
name: Jones, Steven J. M.
name: Bousquet, Jean
name: Mackay, John
Publisher: name: BioMed Central
Year: 2015

description: Background. A positive relationship between genome size and intron length is observed across eukaryotes including Angiosperms plants, indicating a co-evolution of genome size and gene structure. Conifers have very large genomes and longer introns on average than most plants, but impacts of their large genome and longer introns on gene structure has not be described. Results Gene structure was analyzed for 35 genes of Picea glauca obtained from BAC sequencing and genome assembly, including comparisons with A. thaliana, P. trichocarpa and Z. mays. We aimed to develop an understanding of impact of long introns on the structure of individual genes. The number and length of exons was well conserved among the species compared but on average, P. glauca introns were longer and genes had four times more intronic sequence than Arabidopsis, and 2 times more than poplar and maize. However, pairwise comparisons of individual genes gave variable results and not all contrasts were statistically significant. Genes generally accumulated one or a few longer introns in species with larger genomes but the position of long introns was variable between plant lineages. In P. glauca, highly expressed genes generally had more intronic sequence than tissue preferential genes. Comparisons with the Pinus taeda BACs and genome scaffolds showed a high conservation for position of long introns and for sequence of short introns. A survey of 1836 P. glauca genes obtained by sequence capture mostly containing introns <1 Kbp showed that repeated sequences were 10× more abundant in introns than in exons. Conclusion Conifers have large amounts of intronic sequence per gene for seed plants due to the presence of few long introns and repetitive element sequences are ubiquitous in their introns. Results indicate a complex landscape of intron sizes and distribution across taxa and between genes with different expression profiles.
Effects of high meal frequency on body weight loss, appetite regulation and PYY levels
Creators: name: Cyr, Marie-Josee
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Health Sciences, Nutrition.

description: Whether increasing meal frequency leads to greater body weight loss, better appetite control and higher levels of PYY remains to be determined. The purpose of this study is to investigate the effect of high MF (HMF) on body weight loss, appetite and PYY in healthy obese men and women. Sixteen obese individuals were randomized to an 8-week equicaloric energy restriction (-700 kcal/day) that either consisted of HMF (3 meals/day and 3 snacks/day; age= 34.63+/-9.50 y and BMI=37.1+/-4.6 kg/m 2) or low MF (LMF) (3 meals/day; age=36.3+/-7.4 y and BMI=34.8+/-4.0 kg/m2). Baseline energy needs were determined with indirect calorimetry. Appetite (VAS) and body composition (DEXA) were assessed before and after weight loss. Body weight was significantly decreased in both groups (p<0.001), but no significant difference was found between conditions (p>0.05). Significant higher levels of fullness at time 120min and at time 300min was noted for the LMF group (p< .05). PYY levels were comparable across conditions and remained unchanged over the intervention. These findings suggest that increasing MF under conditions of equicaloric energy restriction does not increase weight loss. Further, no favorable effects of increased MF on appetite and on PYY levels were noted.
Characterizing the CNS protection induced by systemic administration of the oncolytic mutant virus DeltaM51-VSV
Creators: name: Balathasan, Lukxmi
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Biology, Microbiology.
subject: Biology, Virology.

description: Direct brain infection with VSV in mice, including the attenuated DeltaM51 strain, results in widespread viral replication, leading to irreversible and often fatal damage. When DeltaM51-VSV is administered i.v., a trace amount of the virus is found within the brain, but is eventually cleared leaving the animal physically undamaged. In response to a peripheral infection, it seems that the host is able to mount an antiviral state in the CNS. Here, I show that by "priming" the host with mutant VSV prior to direct injection of VSV into the CNS, the host is able to send "warnings" in the form of cellular messengers and/or chemical signals preparing the brain to protect itself by any means possible against VSV. I used in vivo imaging techniques coupled with direct labelling of brain tissue sections to assess the effects of priming and CNS protection. My experiments indicate that priming mice with the interferon inducing mutant VSV, DeltaM51-VSV, is in fact CNS protective. Priming limits VSV spread in the brain not by preventing infection of neurons, but by rapid induction of apoptosis in either infected cells or cells neighbouring areas of active infection. Further investigation into the factor(s) or mechanism(s) mediating viral clearance and CNS protection indicates that the innate immune system is able to control and clear DeltaM51-VSV from the CNS before an adaptive response is required.
The flipside: Young womens' understanding of the risks in skateboarding
Creators: name: Young, Alana
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Health Sciences, General.

description: Through the examination of 12 young women skateboarders' narratives, I explore skateboarding as a gendered performance which challenges existing cultural norms about gender through the corporeal display of risk-taking and the ability to withstand pain and injury. Most of the participants construct themselves as 'alternative' women who engage in 'masculine' practices, rejecting dominant notions of femininities. Although skateboarding provides young women with a space to complicate and challenge dominate discourses of gender, skateboarding nevertheless also reinforces dominant constructions of gender. Indeed, young women struggled to establish 'alternative' identities as they are not immune to the ideological power of the dominant codes embedded in the social structures. Using a feminist poststructuralist framework (Lupton, 1999; Weedon, 1997), I explore how discursive power contributes to the construction of women's subjectivities as skateboarders and risk-takers by examining how female skateboarders come to conform to, resist and/or reconstruct dominant notions of 'femininities' and risk.
Examining the association between sleep duration, diet and body mass index in Quebec children
Creators: name: Tatone-Tokuda, Fabiola E
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Health Sciences, Epidemiology.

description: The prevalence of obesity in young children is increasing. Sleep duration is suggested to affect the regulation of body weight through changes in metabolic hormones that regulate appetite, food selection, and energy expenditure. Using data obtained from the Quebec Longitudinal Study of Child Development, this study prospectively examined: 1) the association between longitudinal sleep duration pattern (LSDP) (age 2.5 to 6 years) and overweight/obesity at age 6 and 7 years; and, 2) whether such an association may be mediated by dietary intake and/or eating behaviour at the population level. Associations were examined using multivariate logistic regression methods, with adjustments for potential confounders. Boys with a 'short persistent or short increasing ' LSDP had significantly greater odds of being overweight/obese at age 6 and 7 years, in comparison to boys with an '11-hour persistent ' LSDP. This association was partially mediated by problematic eating behaviours. LSDP did not associate with overweight/obesity in girls.
Porphyromonas gingivalis and the Participatory Role of Interleukin-1beta in the Progression of Atherosclerosis
Creators: name: Chan, Joshua Y.S
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Chemistry, Biochemistry.

description: Periodontal disease promotes atherosclerosis via a poorly defined mechanism. Our laboratory has previously shown that caspase-1, responsible for activating IL-1beta, is important in this process. We hypothesized that Porphyromonas gingivalis infection requires activated IL-1beta to promote atherosclerosis. Six-week old IL-1beta-/- apoE-/- mice of both genders received 15 oral inoculations of P.gingivalis. Detection of anti-P.gingivalis antibodies in serum of inoculated mice confirmed successful infection. Unexpectedly, atherosclerosis at age 17 weeks showed no effect of infection on IL-1beta+/+ mice. Moreover, contrary to our hypothesis, inoculated IL-1beta-/- females showed increased rather than decreased atherosclerosis compared to inoculated IL-1beta+/+ and non-inoculated IL-1beta-/-. Thus, either IL-1beta does not playa role in atherosclerosis development following P.gingivalis infection or there is a compensatory mechanism. IL-1beta deficiency may stimulate another pathway to promote P.gingivalis-induced atherosclerosis. Elucidation of the pathway by which P.gingivalis infection contributes to atherosclerosis development could reveal novel targets for therapy to impede disease progression.
Multiplexor categories and models of soft linear logic
Creators: name: Redmond, Brian F
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Mathematics.

description: This thesis furthers our semantical understanding of polynomial time complexity by clarifying the semantical status of Lafont's soft linear logic, a logical system complete for polynomial time computation. We shall see that soft linear logic is ideal for this purpose because it possesses a very natural and simple mathematical interpretation. To begin, we introduce the notion of a multiplexor category, which is the categorical interpretation of soft linear logic. We show that a multiplexor category provides a denotational semantics for soft linear logic and that the exponential operator can be interpreted canonically as a certain type of limit. This leads to a large class of models and motivates us to introduce a new class of AJM games which we shall call noetherian. Such games may be infinite, but do not have infinite length plays (i.e. there are no infinite increasing chains of plays in their game trees), hence total strategies will naturally compose. Motivated by notions in complexity theory, we are led to introduce a finitary version of soft linear logic and a corresponding notion of finitary multiplexor category. One of the main results in this thesis is a categorical method for constructing a multiplexor category from a finitary one, called the S-construction, which leads to a stratified view of soft linear logic. This interpretation is inspired by the characterization of PTIME by uniformly polynomial circuits in complexity theory. Our construction has many applications. First, we use it to give a realizability model and a new proof that any algorithm representable in soft linear logic is polytime. Next, we utilize the S-construction to obtain a stratified finite game model of soft linear logic and prove a full-completeness result. Finally, we use it to give an alternative description of a model that has recently appeared in the literature. We also note that the stratified interpretation allows for placing polynomial depth restrictions on the length of plays in our game model. Again, this is consistent with our circuit analogy. We feel that this work provides an important first step towards a truly semantic perspective on PTIME complexity.
Late medieval Benedictine anxieties and the politics of John Lydgate
Creators: name: Webber, Reginald
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Biography.
subject: Literature, English.

description: In Reform and Cultural Revolution, James Simpson has argued that the many affiliations of John Lydgate (1370-1449) mitigate against the traditional critical portrayal of the poet as a mere Lancastrian propagandist. My dissertation explores the influence of Lydgate's major affiliation, his Benedictine monasticism, on his political work. I argue that the autonomy of the Benedictine order was already under siege a hundred years before the Tudor dissolution of the monasteries and that the resulting anxieties and remedial strategies of the Benedictine order could not help but have an impact on the work of a fifteenth-century Benedictine poet. I attempt to show that, far from being uniformly "pro-Lancastrian," Lydgate's political poetry (which comprises just about all of his secular work and much of his religious work) is often openly resistant to the main activities of the Lancastrian regime: the usurpation and murder of Richard II; the suppression of the alien priories and the taxation of the church; the invasion of Normandy and the continuation of the war in France after the Treaty of Troyes and the death of Henry V; and the encroachment of the Lancastrian hierarchical church---under the direction of a succession of powerful archbishops of Canterbury---on the autonomy of the religious orders, the monks in particular. I read Lydgate's works as a reflection of Benedictine policy that, more often than not, stands in opposition not only to the Lancastrian dynasty, but to the official hierarchy of the orthodox church in England, and I reconstruct the poet as a Benedictine spokesman very much in control of his own voice.
TANZANIA ELECTRIFICATION INVESTMENT ASSESMENT PROSPECT
Creators: name: Manyama, Francis Faraji
Publisher: name: Zenodo
Year: 2024

description: This presentation constitutes the outcome of a three-weeks capacity building activity on GEP-OnSSET as part of the 2024 Energy Modelling Platform - Global workshop. The authors collected input data, set parameters, calibrated the model, and run electrification investment scenarios for Tanzania in order to explore pathways leading to the achievement of electrification targets. The results of this analysis are not conclusive, but rather the output of experimentation with the model and thus only indicative. You may contact the author for more information and/or questions about the methodology, limitations, and follow-up activities of this study.
Dilute nitride long wavelength semiconductor diode lasers
Creators: name: Zhang, Xia
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Engineering, Electronics and Electrical.

description: This thesis studies the novel dilute nitride semiconductor materials, GaInNAs and GalnNAsSb, and their usage in GaAs-based diode lasers emitting between 1.25 to 1.55 mum in wavelength. This work covers material physical modeling, laser simulations, design and the experimental work of device characterization. The tabulated band anti-crossing theory of the quaternary GaInNAs is formulated. The resulting formulas are further corrected by our experimental observations. This modified band anti-crossing theory is implemented into the commercial laser simulator Las2D. Together with other electrical and optical models equipped with the unique GaInNAs parameters, Las2D becomes the first simulator that calculates the operational behavior of dilute nitride lasers. A two-dimensional simulation algorithm is discovered using the samples of ridge waveguide GalnAs/GaAs lasers that emit at 1.0 mum in wavelength. This algorithm is used in the calibration of the Las2D simulator for dilute nitride lasers. Using the calibrated simulator, several optimized quantum well designs for high-speed, temperature-insensitive devices are suggested with special considerations on the carrier uneven distributions in quantum wells and the nitrogen-induced gain reduction that occurs in dilute nitride material. Fabry-Perot cavity, ridge waveguide lasers emitting at 1275 nm were fabricated by molecular beam epitaxy using a double quantum well GaInNAs (well)---GaAs (barrier) structure. A complete set of static and dynamic characterizations were carried out on those lasers to evaluate dilute nitride material properties as an active media. The temperature dependent light-current (L-I) measurements demonstrated a temperature insensitive device with a characteristic temperature as high as 155 K. Although challenges in material quality remain, the lasers show lasing properties similar to conventional GaAs- and InP-based lasers with respect to the transparency current (6 mA), the material gain (1000 cm -1), the optical loss (7 cm-1), the beam quality (single transverse mode operation, 2.8 in linewidth enhancement factor, 0.55 nm/K in the rate of spectral temperature shift), and the maximum modulation bandwidth (9.7 GHz). The GaInNAsSb QW structure allows the further extension of the laser emitting wavelength to the desired 1.55 mum range. Although the quantum wells and the nitrogen-content barrier challenge the crystal growth, a room temperature, continuous-wave operating GaInNAsSb (quantum well)---GaNAs (barrier) laser was demonstrated for the first time with a record long operating wavelength (1553 nm) for GaAs-based lasers. L-I measurements were carried out on those lasers. The laser optical gain and loss properties were studied using the unique cavity loss dependent analysis.
The effect of LMNA mutations on lamin AC and binding partner interactions and cellular distribution
Creators: name: Labib, Sarah
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: subject: Chemistry, Biochemistry.

description: Mutations in the LMNA gene, which encodes the nuclear intermediate filament proteins lamin A and lamin C, are associated with over ten tissue-specific diseases, including Dilated Cardiomyopathy (DCM) and lone Atrial Fibrillation (lone AF). There is no clear genotype-phenotype relationship between the location of the mutation and the associated disease phenotype. The general hypothesis of this thesis is that LMNA mutations exert their tissue-specific effects via the perturbation of lamin A and lamin C's specific interacting partners. Protein kinase C alpha, PKCalpha, is a lamin A/C binding partner implicated in heart failure and cardiac hypertrophy. Furthermore, abnormal PKCalpha function results in IKAch activity associated with chronic AF. My first aim is to identify specific phenotypes associated with three laminopathies: lone AF, DCM, and DCM with AF by a) comparing the cellular phenotype induced by LMNA mutations associated with lone AF, DCM, and DCM with AF and b) determining the effect of the mutations on the cellular distribution of PKCalpha. I found two previously unreported mutant lamin A and C phenotypes -- cytoplasmic lamin A/C extrusion and the formation of intranuclear lamin A/C sickle-shaped aggregates associated with one lone AF mutation and one DCM mutation. I show that PKCalpha is mislocalized to the nucleus in C2C12 cells transfected with the same mutants. The E2 conjugating enzyme of the Sumo process, Ubc9, is a reported lamin A/C binding partner. Sumo1 is a post-translational modifying protein that is sequestered within mutant lamin A/C aggregates and has increased substrate conjugation in DCM-associated mutant cells. My second aim is to determine how lamin A and C are involved in the Sumo process by a) investigating Ubc9 cellular distribution and lamin A and C binding in the presence of DCM-associated LMNA mutations and b) determining whether lamin A and/or Care Sumo! binding partners. I show that Ubc9 is mislocalized from the inner nuclear membrane to the mutant lamin A/C aggregates. Co-immunoprecipitation did not show lamin A/C sumoylation by Sumo1. Mass spectrometric analysis indicates that heterogeneous ribonucleoprotein U may be a novel lamin A/C binding partner that is sumoylated by Sumo1. In conclusion, I found that two cellular pathways are perturbed in the presence of LMNA mutations and might account for the specific symptoms observed in the tissue-specific laminopathies. Incorrect activation or deactivation of tissue-specific targets may lead to the wide range of tissue-specific diseases associated with LMNA mutations.
ZARDO'ZLIK SA'NATI TIKUV BUYUMLARINI ZARDO'ZLIK USULI BILAN BEZASH
Creators: name: Samatova, Fotima
Publisher: name: Zenodo
Year: 2025

description: Mazkur maqolada zardoʻzlik sanati va uning tikuv buyumlarini bezashdagi o‘rni haqida so‘z yuritiladi. Zardo‘zlik — o‘ziga xos milliy hunarmandchilik turi bo‘lib, matoga oltin va kumush iplardan, shuningdek, marvarid, tosh va boshqa bezak elementlari yordamida naqsh tushirish san’atidir. Ushbu uslub liboslar, pardalar, sumkalar va boshqa mato buyumlarini nafis va boy koʻrinishga keltiradi. Maqolada zardo‘zlikning tarixi, asosiy usullari va zamonaviy tikuvchilik sohasidagi ahamiyati haqida batafsil ma’lumot beriladi.
Harnessing microbiome and probiotic research in sub-Saharan Africa: recommendations from an African workshop
Creators: name: Reid, Gregor S. D.
name: Nduti, Nicholas
name: Sybesma, Wilbert
name: Kort, Remco
name: Kollmann, Tobias R.
name: Adam, Rod
name: Boga, Hamadi
name: Brown, Eric M.
name: Einerhand, Alexandra
name: El-Nezami, Hani
name: Gloor, Gregory B.
name: Kavere, Irene I.
name: Lindahl, Johanna
name: Manges, Amee R.
name: Mamo, Wondu
name: Martin, Rocio
name: McMillan, Amy
name: Obiero, Jael
name: Ochieng’, Pamela A.
name: Onyango, Arnold
name: Rulisa, Stephen
name: Salminen, Eeva
name: Salminen, Seppo
name: Sije, Antony
name: Swann, Jonathan R.
name: Van Treuren, William
name: Waweru, Daniel
name: Kemp, Steve J.
Publisher: name: BioMed Central
Year: 2015

description: Abstract To augment capacity-building for microbiome and probiotic research in Africa, a workshop was held in Nairobi, Kenya, at which researchers discussed human, animal, insect, and agricultural microbiome and probiotics/prebiotics topics. Five recommendations were made to promote future basic and translational research that benefits Africans.
Sequence-Based Analysis of Structural Organization and Composition of the Cultivated Sunflower (Helianthus annuus L.) Genome
Creators: name: Gill, Navdeep
name: Buti, Matteo
name: Kane, Nolan
name: Bellec, Arnaud
name: Helmstetter, Nicolas
name: Berges, Hélène
name: Rieseberg, Loren H.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Sunflower is an important oilseed crop, as well as a model system for evolutionary studies, but its 3.6 gigabase genome has proven difficult to assemble, in part because of the high repeat content of its genome. Here we report on the sequencing, assembly, and analyses of 96 randomly chosen BACs from sunflower to provide additional information on the repeat content of the sunflower genome, assess how repetitive elements in the sunflower genome are organized relative to genes, and compare the genomic distribution of these repeats to that found in other food crops and model species. We also examine the expression of transposable element-related transcripts in EST databases for sunflower to determine the representation of repeats in the transcriptome and to measure their transcriptional activity. Our data confirm previous reports in suggesting that the sunflower genome is >78% repetitive. Sunflower repeats share very little similarity to other plant repeats such as those of Arabidopsis, rice, maize and wheat; overall 28% of repeats are “novel” to sunflower. The repetitive sequences appear to be randomly distributed within the sequenced BACs. Assuming the 96 BACs are representative of the genome as a whole, then approximately 5.2% of the sunflower genome comprises non TE-related genic sequence, with an average gene density of 18kbp/gene. Expression levels of these transposable elements indicate tissue specificity and differential expression in vegetative and reproductive tissues, suggesting that expressed TEs might contribute to sunflower development. The assembled BACs will also be useful for assessing the quality of several different draft assemblies of the sunflower genome and for annotating the reference sequence.