cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: The Role of ER-Golgi Membrane Contact Sites and of FAPP1 in Phosphoinositide Homeostasis at the Golgi Complex
Creators: name: Masone, Maria Chiara
Publisher: name: The Open University
Year: 2020

description: Initially considered to be a precursor for highly phosphorylated phosphatidylinositol species, phosphatidylinositol 4-phosphate (PI4P) turned out to be “active” in its own right as a pivotal regulator of multiple cellular functions including membrane trafficking, sphingolipid metabolism, autophagy, and cell migration. PI4P levels at the Golgi in control conditions are the result of the balanced activity of Golgi-localized PI4-kinases (PI4KIIIβ and to a lesser extent PI4KIIα) and a single, highly conserved 4-phosphatase known as SAC1, localized in the ER. To coordinate such a variety of functions, multiple layers of regulation are required to modulate PI4P levels in time and space, by directing both PI4P enzymes localization and their activity. Here I show that the phosphatidylinositol 4-phosphate adaptor protein 1 (FAPP1) acts as a PI4P sensor, binds to PI4P and regulates its levels by interacting with and stimulating SAC1 at the level of ER-TGN membrane contact sites (ERTGoCS). At these ERTGoCS, FAPP1 acts as an adaptor that directs and stabilizes SAC1 towards PI4P-rich domains to promote its activity in trans to dephosphorylate PI4P at the TGN. Consequently, FAPP1 depletion leads to a huge increase in PI4P levels at the Golgi. I found that the FAPP1-regulated PI4P pool controls the post-Golgi trafficking of specific cargoes. One of these is the β-lipoprotein ApoB-100, which is more secreted upon FAPP1 depletion, highlighting a possible physiological role of this pool of PI4P controlled at the level of ER-TGN membrane contact sites. Intriguingly, another affected cargo is the autophagy protein ATG9, whose trafficking from the Golgi is increased in FAPP1 KD cells, thus resulting in a strong induction of autophagy. Besides the regulation of specific trafficking events, I found that the pool of PI4P controlled by FAPP1 recruits and promotes the activation of the PI4P-binding oncogene GOLPH3. When PI4P levels increase in FAPP1-KD cells, GOLPH3 is hyperactivated and promotes uncontrolled cell migration and invasion. My thesis work presents new information on the molecular mechanisms underlying the regulation of PI4P at the Golgi complex, identifying FAPP1 as a negative regulator of PI4P levels. It also sheds light on the need to keep PI4P levels within a certain range since an uncontrolled increase in PI4P can result in oncogenic potential and mis-trafficking of selective cargoes. Overall, this work provides novel insights into the homeostatic control of PI4P with an important contribution in understanding the complex picture of PI4P control and function in cell biology.
Bitis rhinoceros
Creators: name: Segniagbeto, Gabriel Hoinsoude
name: Trape, Jean François
name: David, Patrick
name: Ohler, Annemarie
name: Dubois, Alain
name: Glitho, Isabelle Adolé
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Viperidae
Bitis
Bitis rhinoceros

description: Bitis rhinoceros (Schlegel, 1855)
(Fig. 11)
MATERIAL EXAMINED. — 13 specimens (ZMB 19562, South Togo; ZMB 22007, MRAC 62412, “ Togo ”, no precise locality; ZMB 22006, Missahohe; MRAC 29454, MRAC 29456, Badou; MRAC 29741, Atakpame; GHS-W 0224, Diguingue; GHS-W 1285, GHS-W 1290, GHS-Togo 80, Yo [Agome Yo]; GHS-W 1293, Agave; GHS-Togo 35, Agbanon).
MORPHOLOGY. — TL from 265 to 725 mm; 36-40 MSR, keeled; 130-145 Ven, smooth; 18-27 Sc, paired; anal single; 14-15 supralabials; 18-19 scales surrounding the eye; 16-17 infralabials.
DISTRIBUTION. — This species is mostly found in forest. It has been recorded only in ER IV of the country.
REMARK
 Bitis rhinoceros was long regarded as a synonym or a subspecies of Bitis gabonica (Duméril, Bibron & Duméril, 1854). Both taxa were separated at the species level by Lenk et al. (1999) on the basis of molecular analyses. Bitis gabonica has largely been mentioned from forested areas of Togo by Sternfeld (1908b, 1909: 25), Hulselmans & Verheyen (1970), Hulselmans et al. (1970), Harding & Welch (1980), Roman (1984), Rasmussen (1995c), Spawls & Branch (1995) and David & Ineich (1999). Dorandeu (1991) mentioned this taxon as Bitis gabonica rhinoceros. All specimens of “ Bitis gabonica ” from Togo examined by us are indeed referable to Bitis rhinoceros. On the basis of the ranges of both species given in Chippaux (2006), we believe that all literature mentions from Togo refer indeed to Bitis rhinoceros.
description: Published as part of Segniagbeto, Gabriel Hoinsoude, Trape, Jean François, David, Patrick, Ohler, Annemarie, Dubois, Alain & Glitho, Isabelle Adolé, 2011, The snake fauna of Togo: systematics, distribution and biogeography, with remarks on selected taxonomic problems, pp. 325-360 in Zoosystema 33 (3) on page 352, DOI: 10.5252/z2011n3a4, http://zenodo.org/record/4547017
Additional file 2 of Co-establishing an infrastructure for routine data collection to address disparities in infant mortality: planning and implementation
Creators: name: Fareed, Naleef
name: Swoboda, Christine M.
name: Lawrence, John
name: Griesenbrock, Tyler
name: Huerta, Timothy
Publisher: name: figshare
Year: 2022
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences

description: Additional file 2. OEI Data Dictionary. This file includes the complete data dictionaries for the enrollment, birth, exit, and encounter forms used as part of this study.
Paläoökologische Untersuchungen zum Krefeld—Interglazial am Niederrhein
Creators: name: Urban, Brigitte
Publisher: name: Geozon Science Media
Year: 1980

description: Aus dem Bereich der saalezeitlichen Stauchendmoränen im Großraum Krefeld am Niederrhein wurden vier Pollendiagramme aus den Krefelder-Schichten erarbeitet und als Krefeld-Interglazial bezeichnet. Das Profil Römerhof II wurde zudem malakozoologisch untersucht. Die erfaßten vegetationsgeschichtlichen Abschnitte zeigen bei relativer Gleichförmigkeit eine Dominanz der Koniferengehölze, die mit Auewaldelementen (Pterocarya, Alnus, Vitis) das Vegetationsbild am Niederrhein ausgemacht haben. Juglandaceae-Pollen ist ebenso wie der Pollen von Fagus in diesen Abschnitten des Interglazials regelmäßig, allerdings nur in Spuren vertreten. Massulae von Azolla filiculoides sind in allen Profilen zum Teil reichlich vorhanden. Eine stratigraphische Einstufung der gestauchten (Krefelder-Schichten) und der ungestauchten (Kempener-Schichten) wird diskutiert.
description: research
Implicit Regularization and Renormalization of QCD
Creators: name: Sampaio, M. D.
name: Scarpelli, A. P. B.
name: Ottoni, J. E.
name: Nemes, M. C.
Publisher: name: arXiv
Year: 2005
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We apply the Implicit Regularization Technique (IR) in a non-abelian gauge theory. We show that IR preserves gauge symmetry as encoded in relations between the renormalizations constants required by the Slavnov-Taylor identities at the one loop level of QCD. Moreover, we show that the technique handles divergencies in massive and massless QFT on equal footing.
description: (11 pages, 2 figures)
Additional file 1 of The roles, activities and impacts of middle managers who function as knowledge brokers to improve care delivery and outcomes in healthcare organizations: a critical interpretive synthesis
Creators: name: Boutcher, Faith
name: Berta, Whitney
name: Urquhart, Robin
name: Gagliardi, Anna R.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 1. ENTREQ checklist
On the mechanism of microbe inactivation by metallic iron
Creators: name: Noubactep, Chicgoua
Publisher: name: FID GEO
Year: 2011

description: This letter challenges the concept that the metallic iron (Fe0) surface contributes directly to the process of micro-organism inactivation in aqueous solutions. It is shown that any antimicrobial properties of Fe0 is related to the cycle of expansion/contraction accompanying aqueous iron corrosion. This demonstration corroborates the concept that aqueous contaminant removal in the presence of Fe0 mostly occurs at the Fe-oxide/water interface or within the oxide-film on Fe0.
Remarkable changes in the near-infrared spectrum of the nova-like variable V4332 Sgr
Creators: name: Banerjee, D. P. K.
name: Varricatt, P. W.
name: Ashok, N. M.
name: Launila, O.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We report on recent near-IR observations of V4332 Sgr - the nova-like variable that erupted in 1994. Its rapid, post-outburst evolution to a cool M type giant/supergiant, soon after its outburst, had showed that it was an unusual object differing from other eruptive variables like classical/symbiotic novae or born-again AGB stars. The present study of V4332 Sgr was motivated by the keen interest in the recent eruption of V838 Mon - which along with V4332 Sgr - is believed to belong to a new class of objects (we propose they may be called "quasi-novae"). Our observations show new developments in the evolution of V4332 Sgr. The most striking feature is the detection of several molecular bands of AlO - a rarely seen molecule in astronomical spectra - in the JHK spectra. Many of these bands are being detected for the first time. The only other detection of some of these AlO bands are in V838 Mon, thereby showing further spectral similarities between the two objects. JHK photometry shows the development of a new dust shell around V4332 Sgr with a temperature of ~ 900K. This dust shell does not appear to be associated with ejecta of the 1994 outburst but is due to a second mass-loss episode which is not expected in a classical nova outburst. The cold molecular environment, suggested by the AlO emission, is also not expected in novae ejecta. We model the AlO bands and also discuss the possible formation mechanism of the AlO.
description: To appear in Ap.J(L), 3 figures
Polar flock with bond disorder
Creators: name: Singh, Jay Prakash
name: Pattanayak, Sudipta
name: Mishra, Shradha
Publisher: name: arXiv
Year: 2020
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: In this study, we introduce a minimal model for a collection of polar self-propelled particles (SPPs) on a two-dimensional substrate where each particle has a different ability to interact with its neighbours. The SPPs interact through a short-range alignment interaction and interaction strength of each particle is obtained from a uniform distribution. Moreover, the volume exclusion among the SPPs is taken care of by introducing a repulsive interaction among them. We characterise the ordered steady state and kinetics of the system for different strengths of the disorder. We find that the presence of the disorder does not destroy the usual long-range ordering in the system. To our surprise, we note that the density clustering is enhanced in the presence of the disorder. Moreover, the disorder leads to the formation of a random network of different interaction strengths, which makes the alignment weaker and it results in the slower dynamics. Hence, the disorder leads to more cohesion among the particles. Furthermore, we note that the kinetics of the ordered state remains unaffected in the presence of the disorder. Size of orientationally ordered domains and density clusters grow with time with dynamic growth exponents $z_{o} \sim 2$ and $z_ρ \sim 4$, respectively.
Additional file 1 of Reducing expectations for antibiotics in primary care: a randomised experiment to test the response to fear-based messages about antimicrobial resistance
Creators: name: Roope, Laurence S. J.
name: Tonkin-Crine, Sarah
name: Herd, Natalie
name: Michie, Susan
name: Pouwels, Koen B.
name: Castro-Sanchez, Enrique
name: Sallis, Anna
name: Hopkins, Susan
name: Robotham, Julie V.
name: Crook, Derrick W.
name: Peto, Tim
name: Peters, Michele
name: Butler, Christopher C.
name: A. Sarah Walker
name: Wordsworth, Sarah
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology
subject: FOS: Biological sciences

description: Additional file 1. Survey instrument.
Evolution of the tRNALeu (UAA) Intron and Congruence of Genetic Markers in Lichen-Symbiotic Nostoc.
Creators: name: Kaasalainen, Ulla
name: Olsson, Sanna
name: Rikkinen, Jouko
Publisher: name: FID GEO
Year: 2015

description: The group I intron interrupting the tRNALeu UAA gene (trnL) is present in most cyanobacterial genomes as well as in the plastids of many eukaryotic algae and all green plants. In lichen symbiotic Nostoc, the P6b stem-loop of trnL intron always involves one of two different repeat motifs, either Class I or Class II, both with unresolved evolutionary histories. Here we attempt to resolve the complex evolution of the two different trnL P6b region types. Our analysis indicates that the Class II repeat motif most likely appeared first and that independent and unidirectional shifts to the Class I motif have since taken place repeatedly. In addition, we compare our results with those obtained with other genetic markers and find strong evidence of recombination in the 16S rRNA gene, a marker widely used in phylogenetic studies on Bacteria. The congruence of the different genetic markers is successfully evaluated with the recently published software Saguaro, which has not previously been utilized in comparable studies.
description: Open-Access-Publikationsfonds 2015
Exact Maximal Height Distribution of Fluctuating Interfaces
Creators: name: Majumdar, Satya N.
name: Comtet, Alain
Publisher: name: arXiv
Year: 2004
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We present an exact solution for the distribution P(h_m,L) of the maximal height h_m (measured with respect to the average spatial height) in the steady state of a fluctuating Edwards-Wilkinson interface in a one dimensional system of size L with both periodic and free boundary conditions. For the periodic case, we show that P(h_m,L)=L^{-1/2}f(h_m L^{-1/2}) for all L where the function f(x) is the Airy distribution function that describes the probability density of the area under a Brownian excursion over a unit interval. For the free boundary case, the same scaling holds but the scaling function is different from that of the periodic case. Numerical simulations are in excellent agreement with our analytical results. Our results provide an exactly solvable case for the distribution of extremum of a set of strongly correlated random variables.
description: 4 pages revtex (two-column), 1 .eps figure included
Letheobia crossi
Creators: name: Segniagbeto, Gabriel Hoinsoude
name: Trape, Jean François
name: David, Patrick
name: Ohler, Annemarie
name: Dubois, Alain
name: Glitho, Isabelle Adolé
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Typhlopidae
Letheobia
Letheobia crossi

description: Letheobia crossi (Boulenger, 1893)
MATERIAL EXAMINED. — 2 specimens (IRD 92- T, Fazao, IRD 102- T, Alédjo [Alédjo Kadara]).
MORPHOLOGY. — Morphological characters of these specimens were checked by Youssouph Mané and appeared in Trape & Segniagbeto (2008).
DISTRIBUTION. — First record from Togo. Fazao and Alédjo, both in ER II, are the sole localities recorded in Togo for this species.Previously, this species was considered to be endemic to Nigeria (Roux-Estève 1974).
description: Published as part of Segniagbeto, Gabriel Hoinsoude, Trape, Jean François, David, Patrick, Ohler, Annemarie, Dubois, Alain & Glitho, Isabelle Adolé, 2011, The snake fauna of Togo: systematics, distribution and biogeography, with remarks on selected taxonomic problems, pp. 325-360 in Zoosystema 33 (3) on page 350, DOI: 10.5252/z2011n3a4, http://zenodo.org/record/4547017
Efektywność wykorzystania środków trwałych w gospodarstwach rolnych
EFFICIENCY IN THE USE OF FIXED ASSETS ON FARM HOLDINGS
Creators: name: Kołoszko-Chomentowska, Zofia
name: Kołoszko-Chomentowska, Zofia
Publisher: name: Unknown
Year: 2017
Subjects: subject: Agribusiness
subject: środki trwałe
subject: efektywność
subject: reprodukcja
subject: gospodarstwo rolne

description: This paper presents fixed-asset turnover in agricultural holdings in the Podlaskie voivodeship. Fixed-asset turnover was assessed on the basis of their productivity and profitability. Selected methods of financial analysis were also applied. Assessments of fixed-asset reproduction were conducted on the basis of the fixed-asset reproduction rate. Positive changes in the fixed assets owned by agricultural holdings were observed. As the value of fixed assets grew, their turnover also increased, and farms achieved better economic results. Farms with larger areas and more machinery and equipment (group C) were characterized by the greatest fixed-asset turnover, and only farms from this group had the capability of expanded reproduction. These farms took advantage of external financing for fixed assets more often, but the degree in which agricultural holdings were dependent on foreign capital was low in all groups.
Testing the Suitability of Zerovalent Iron Materials for Reactive Walls
Creators: name: Noubactep, Chicgoua
name: Meinrath, Günther
name: Dietrich, Peter
name: Sauter, Martin
name: Merkel, B. J.
Publisher: name: FID GEO
Year: 2005

description: Zerovalent iron (ZVI) has been proposed as reactive material in permeable in-situ walls for contaminated groundwater. An economically feasible ZVI reactive wall requires cheap but efficient iron materials. From an uranium treatability study and results of iron dissolution in 0.002 M EDTA by five selected ZVI materials, it is shown that current research and field implementation is not based on a rational selection of application-specific iron metal sources. An experimental procedure is proposed which could enable a better material characterization. This procedure consists in mixing ZVI materials and reactive additives including contaminant releasing materials (CRM) in long term batch experiments and characterise the contaminant concentration over the time.
Additional file 2 of The roles, activities and impacts of middle managers who function as knowledge brokers to improve care delivery and outcomes in healthcare organizations: a critical interpretive synthesis
Creators: name: Boutcher, Faith
name: Berta, Whitney
name: Urquhart, Robin
name: Gagliardi, Anna R.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 2. Search strategy
Postawa konsumentów względem wdrażania idei segregacji odpadów piekarsko-cukierniczych „u źródła”
CONSUMER ATTITUDE TOWARDS THE IMPLEMENTATION OF THE IDEA OF BAKERY AND CONFECTIONERY WASTE SEGREGATION „AT SOURCES”
Creators: name: Korzeniowska-Ginter, Renata
name: Dereszewska, Alina
name: Spigarska, Ewa
name: Korzeniowska-Ginter, Renata
name: Dereszewska, Alina
name: Spigarska, Ewa
Publisher: name: Unknown
Year: 2017
Subjects: subject: Agribusiness
subject: odpady piekarsko-cukiernicze
subject: segregacja „u źródła”

description: The aim of the study was to evaluate the perception of the problem of waste of bread, the tendency of consumers to separate their waste bakery and confectionery, the factors that encourage and opinions on the directions of use of this type of waste. A survey was conducted among 314 consumers. It was found that waste of bread especially for people over the age of 40 years is a very important issue. The respondents showed a high acceptance in relation to the concept of waste segregation bakery and confectionery. Factors supporting segregation would be properly prepared containers and the awareness that the bread is not thrown in the trash. Respondents expressed scepticism in relation to the use of bakery and confectionery waste to produce biogas or methanol. Demonstrated popular support indicates the need for action in the municipalities allow for collection of waste bakery and confectionery to their effective management, and the conduct in this field of educational activities.
Study of the Modified Gaussian Model on olivine diagnostic spectral features and its applications in space weathering experiments
Creators: name: Han, Hui-Jie
name: Lu, Xiao-Ping
name: Yang, Ya-Zhou
name: Zhang, Hao
name: Mutelo, Admire Muchimamui
Publisher: name: arXiv
Year: 2020
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The absorption features of olivine in visible and near-infrared (VNIR) reflectance spectra are the key spectral parameters in its mineralogical studies. Generally, these spectral parameters can be obtained by exploiting the Modified Gaussian Model (MGM) with a proper continuum removal. However, different continua may change the deconvolution results of these parameters. This paper investigates the diagnostic spectral features of olivine with diverse chemical compositions. Four different continuum removal methods with MGM for getting the deconvolution results are presented and the regression equations for predicting the Mg-number (Fo#) are introduced. The results show that different continua superimposed on the mineral absorption features will make the absorption center shift, as well as the obvious alterations in shape, width, and strength of the absorption band. Additionally, it is also found that the logarithm of a second-order polynomial continuum can match the overall shape of the spectrum in logarithmic space, and the improved regression equations applied to estimate the chemical composition of olivine-dominated spectra also have a better performance. As an application example, the improved approach is applied to pulse laser irradiated olivine grains to simulate and study the space weathering effects on olivine diagnostic spectral features. The experiments confirm that space weathering can make the absorption band center shift toward longer wavelength. Therefore, the Fo# estimated from remote sensing spectra may be less than its actual chemical composition. These results may provide valuable information for revealing the difference between the spectra of olivine grains and olivine-dominated asteroids.
description: 27 pages, 15 figures
Nonfactorizable contributions in anti-B0 -> Ds+ Ds- and anti-Bs0 -> D+ D- decays
Creators: name: Eeg, J. O.
name: Fajfer, S.
name: Hiorth, A.
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The decay amplitudes for anti-B0 -> Ds+ Ds- and anti-Bs0 -> D+ D- have no factorizable contributions. We suggest that dominant contributions to the decay amplitudes arise from two chiral loop contributions and one soft gluon emission contribution. Then we determine branching ratios BR(anti-B0 -> Ds+ Ds-) ~ 7E-5 and BR(anti-Bs0 -> D+ D-) ~ 1E-3.
description: LaTeX, 5 pages, 4 figures, contributed paper for LP03
What is the probability of intersecting the set of Brownian double points?
Creators: name: Pemantle, Robin
name: Peres, Yuval
Publisher: name: arXiv
Year: 2004
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60J45 (Primary)

description: We give potential theoretic estimates for the probability that a set $A$ contains a double point of planar Brownian motion run for unit time. Unlike the probability for $A$ to intersect the range of a Markov process, this cannot be estimated by a capacity of the set $A$. Instead, we introduce the notion of a capacity with respect to two gauge functions simultaneously. We also give a polar decomposition of $A$ into a set that never intersects the set of Brownian double points and a set for which intersection with the set of Brownian double points is the same as intersection with the Brownian path.
description: Published in at http://dx.doi.org/10.1214/009117907000000169 the Annals of Probability (http://www.imstat.org/aop/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Additional file 4 of The influence of equine body weight gain on inflammatory cytokine expressions of adipose tissue in response to endotoxin challenge
Creators: name: Blaue, Dominique
name: Schedlbauer, Carola
name: Starzonek, Janine
name: Gittel, Claudia
name: Brehm, Walter
name: Blüher, Matthias
name: Pfeffer, Martin
name: Vervuert, Ingrid
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Computational Biology

description: Additional file 4. Comparison of mRNA expression levels between AT depots at t0, t1 and t2.
Minimal and maximal elements in Kazhdan-Lusztig double sided cells of $S_n$ and Robinson-Schensted correspondance
Creators: name: Hohlweg, Christophe
Publisher: name: arXiv
Year: 2003
Subjects: subject: Representation Theory (math.RT)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05E15, 05E10, 20C08

description: In symmetric groups, a two-sided cell is the set of all permutations which are mapped by the Robinson-Schensted correspondence on a pair of tableaux of the same shape. In this article, we show that the set of permutations in a two-sided cell which have a minimal number of inversions is the set of permutations which have a maximal number of inversions in conjugated Young subgroups. We also give an interpretation of these sets with particular tableaux, called reading tableaux. As corollary, we give the set of elements in a two-sided cell which have a maximal number of inversions.
description: 10 pages, final version. This is the final version, to appear in Discrete math
A horizontal gene transfer supported the evolution of an early metazoan biomineralization strategy
Creators: name: Jackson, Daniel J.
name: Macis, Luciana
name: Reitner, Joachim
name: Wörheide, Gert
Publisher: name: FID GEO
Year: 2011

description: Background The synchronous and widespread adoption of the ability to biomineralize was a defining event for metazoan evolution during the late Precambrian/early Cambrian 545 million years ago. However our understanding on the molecular level of how animals first evolved this capacity is poor. Because sponges are the earliest branching phylum of biomineralizing metazoans, we have been studying how biocalcification occurs in the coralline demosponge Astrosclera willeyana. Results We have isolated and characterized a novel protein directly from the calcified spherulites of A. willeyana. Using three independent lines of evidence (genomic architecture of the gene in A. willeyana, spatial expression of the gene product in A. willeyana and genomic architecture of the gene in the related demosponge Amphimedon queenslandica), we show that the gene that encodes this protein was horizontally acquired from a bacterium, and is now highly and exclusively expressed in spherulite forming cells. Conclusions Our findings highlight the ancient and close association that exists between sponges and bacteria, and provide support for the notion that horizontal gene transfer may have been an important mechanism that supported the evolution of this early metazoan biomineralisation strategy.
Non-reciprocal optical reflection from a bidimensional array of subwavelength holes in a metallic film
Creators: name: Sarrazin, Michael
name: Vigneron, Jean Pol
Publisher: name: arXiv
Year: 2004
Subjects: subject: Optics (physics.optics)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: Using simulations and theoretical arguments we investigate the specular reflection of a perforated gold film deposited on a glass substrate. A square lattice of cylindrical holes is assumed to produce the periodic lateral corrugation needed to hybridize the surface plasmons with radiative states. It is shown that, contrasting transmission approaches, a knowledge of the reflection on either side of the film provides separate information on the gold-vacuum surface plasmons and on the gold-glass interface plasmons. Recent experimental data on a specific implementation of this system are reexamined; these show a good agreement between the measured reflections and the simulations in both directions of incident wave probes. This confirms the importance of taking into account the reflection asymmetry in the far-field assessment of surface plasmons properties.
description: 4 pages, 3 figures. Published version
Probing Energetic Light Dark Matter with Multi-Particle Tracks Signatures at DUNE
Creators: name: De Roeck, Albert
name: Kim, Doojin
name: Moghaddam, Zahra Gh.
name: Park, Jong-Chul
name: Shin, Seodong
name: Whitehead, Leigh H.
Publisher: name: arXiv
Year: 2020
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The search for relativistic scattering signals of cosmogenic light dark matter at terrestrial detectors has received increasing attention as an alternative approach to probe dark-sector physics. Large-volume neutrino experiments are well motivated for searches of dark matter that interacts very weakly with Standard Model particles and/or that exhibits a small incoming flux. We perform a dedicated signal sensitivity study for a detector similar to the one proposed by the DUNE Collaboration for cosmogenic dark-matter signals resulting from a non-minimal multi-particle dark-sector scenario. The liquid argon time projection chamber technology adopted for the DUNE detectors is particularly suited for searching for complicated signatures owing to good measurement resolution and particle identification, as well as $dE/dx$ measurements to recognize merged tracks. Taking inelastic boosted dark matter as our benchmark scenario that allows for multiple visible particles in the final state, we demonstrate that the DUNE far detectors have a great potential for probing scattering signals induced by relativistic light dark matter. Detector effects and backgrounds have been estimated and taken into account. Model-dependent and model-independent expected sensitivity limits for a DUNE-like detector are presented.
description: 35 pages, 11 figures, 2 tables, journal published version
Shear modulus, heat capacity, viscosity and structural relaxation time of Na2O–Al2O3–SiO2 and Na2O–Fe2O3–Al2O3–SiO2 melts
Creators: name: Falenty, Katarzyna
name: Webb, Sharon
Publisher: name: Springer-Verlag
Year: 2010

description: The configurational heat capacity, shear modulus and shear viscosity of a series of Na2O–Fe2O3–Al2O3–SiO2 melts have been determined as a function of composition. A change in composition dependence of each of the physical properties is observed as Na2O/(Na2O + Al2O3) is decreased, and the peralkaline melts become peraluminous and a new charge-balanced Al-structure appears in the melts. Of special interest are the frequency dependent (1 mHz–1 Hz) measurements of the shear modulus. These forced oscillation measurements determine the lifetimes of Si–O bonds and Na–O bonds in the melt. The lifetime of the Al–O bonds could not, however, be resolved from the mechanical spectrum. Therefore, it appears that the lifetime of Al–O bonds in these melts is similar to that of Si–O bonds with the Al–O relaxation peak being subsumed by the Si–O relaxation peak. The appearance of a new Al-structure in the peraluminous melts also cannot be resolved from the mechanical spectra, although a change in elastic shear modulus is determined as a function of composition. The structural shear-relaxation time of some of these melts is not that which is predicted by the Maxwell equation, but up to 1.5 orders of magnitude faster. Although the configurational heat capacity, density and shear modulus of the melts show a change in trend as a function of composition at the boundary between peralkaline and peraluminous, the deviation in relaxation time from the Maxwell equation occurs in the peralkaline regime. The measured relaxation times for both the very peralkaline melts and the peraluminous melts are identical with the calculated Maxwell relaxation time. As the Maxwell equation was created to describe the timescale of flow of a mono-structure material, a deviation from the prediction would indicate that the structure of the melt is too complex to be described by this simple flow equation. One possibility is that Al-rich channels form and then disappear with decreasing Si/Al, and that the flow is dominated by the lifetime of Si–O bonds in the Al-poor peralkaline melts, and by the lifetime of Al–O bonds in the relatively Si-poor peralkaline and peraluminous melts with a complex flow mechanism occurring in the mid-compositions. This anomalous deviation from the calculated relaxation time appears to be independent of the change in structure expected to occur at the peralkaline/peraluminous boundary due to the lack of charge-balancing cations for the Al-tetrahedra.
Additional file 3 of The roles, activities and impacts of middle managers who function as knowledge brokers to improve care delivery and outcomes in healthcare organizations: a critical interpretive synthesis
Creators: name: Boutcher, Faith
name: Berta, Whitney
name: Urquhart, Robin
name: Gagliardi, Anna R.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 3. Eligibility criteria
Atheris chlorechis
Creators: name: Segniagbeto, Gabriel Hoinsoude
name: Trape, Jean François
name: David, Patrick
name: Ohler, Annemarie
name: Dubois, Alain
name: Glitho, Isabelle Adolé
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Viperidae
Atheris
Atheris chlorechis

description: Atheris chlorechis (Pel, 1851)
(Fig. 10)
MATERIAL EXAMINED. — 1 specimen (GHS-W 1035), Badou.
MORPHOLOGY. — TL 410 mm; 33 MSR, keeled; 153 Ven, smooth; 55 Sc, paired; anal single; 17 scales surrounding the eye; 12 interorbital scales on upper head surface; 12 supralabials; 11 infralabials.
 DISTRIBUTION. — This species is essentially a forestdweller. It has previously been mentioned from Togo by Sternfeld (1908b, 1909: 26), Harding & Welch (1980), Golay et al. (1993), David & Ineich (1999), Anonymous (2002), Ernst & Rödel (2002) and Chippaux (2006).
description: Published as part of Segniagbeto, Gabriel Hoinsoude, Trape, Jean François, David, Patrick, Ohler, Annemarie, Dubois, Alain & Glitho, Isabelle Adolé, 2011, The snake fauna of Togo: systematics, distribution and biogeography, with remarks on selected taxonomic problems, pp. 325-360 in Zoosystema 33 (3) on page 351, DOI: 10.5252/z2011n3a4, http://zenodo.org/record/4547017
Subgrain boundaries in Antarctic ice quantified by X-ray Laue diffraction
Creators: name: Weikusat, Ilka
name: Miyamoto, Atsushi
name: Faria, Sergio H.
name: Kipfstuhl, Sepp
name: Azuma, Nobuhiko
name: Hondoh, Takeo
Publisher: name: FID GEO
Year: 2011

description: Ice in polar ice sheets undergoes deformation during its flow towards the coast. Deformation and recrystallization microstructures such as subgrain boundaries can be observed and recorded using high-resolution light microscopy of sublimation-edged sample surfaces (microstructure mapping). Subgrain boundaries observed by microstructure mapping reveal characteristic shapes and arrangements. As these arrangements are related to the basal plane orientation, full crystallographic orientation measurements are needed for further characterization and interpretation of the subgrain boundary types. X-ray Laue diffraction measurements validate the sensitivity of different boundary types with sublimation used by microstructure mapping for the classification. X-ray Laue diffraction provides misorientation values of all four crystal axes. Line scans across a subgrain boundary pre-located by microstructure mapping can determine the rotation axis and angle. Together with the orientation of the subgrain boundary this yields information on the dislocation types. Tilt and twist boundaries composed of dislocations lying in the basal plane, and tilt boundaries composed of nonbasal dislocations were found. A statistical analysis shows that nonbasal dislocations play a significant role in the formation of all subgrain boundaries.
Cellular regulation of inflammatory processes in periodontal disease controlled by the ανβ6 integrin, a junctional epithelium cell receptor
Creators: name: Nica, Daniela
Publisher: name: University of British Columbia
Year: 2011

description: Periodontitis is an inflammatory disease caused by a combination of specific bacteria, host susceptibility and environmental factors. The sulcular and junctional epithelia act as the barrier for the plaque biofilm. Increased anaerobic pathogens are potent virulent factors that interact with the gingival epithelium inducing inflammatory cytokines including TGFβ. As an immunosuppressive cytokine, TGFβ acts as a growth inhibitor of the junctional epithelium. The latent form of TGFβ can be activated by άvβ6 integrin, a keratinocyte cell receptor found in the junctional epithelium (JE). In this study we have used a rat model of periodontitis induced by LPS and blocking antibodies for άcvβ6 integrin to manipulate the function of this integrin in order to observe its role in inflammation. Pocket epithelium formation was also investigated in a knock out (KO) mouse models for β6, TSP-1 and for both β6 and TSP-1. In the rat model, 24 animals were divided in four groups that were treated for 8 weeks. The experimental groups (n=6) were treated with blocking (6.3G9) or non-blocking (7.8B3) anti-β6 antibody and LPS. The control group was treated with pyrogen free water and one group was treated with LPS alone. Measurements of the junctional epithelium migration for area and length below the cementum enamel junction (CEJ) were quantified and compared statistically. Our findings showed that there was significant differences in JE migration between all rat treatment groups (ANOVA and Tukey test, p<0.05). Also inflammatory cellular infiltration was evaluated and was statistically different between the 6.3G9+LPS group and 7.8B3+LPS group and between the 6.3G9+LPS group and LPS group alone(p<0.05 ANOVA) and not statistically different between LPS and 7.8B3+LPS group (p >0.05 unpaired t-Test). In the second model histological analysis was carried out for the knock out mice. In the murine KO model JE area and length of migration bellow the CEJ was found statistically different between the three different KO strains of mouse (ANOVA, p<0.05). The Tukey test found that the difference between the double KO and β6 KO was not significant for area only. We concluded that άcvβ6 integrin plays an important role in inflammation possibly through activation of TGFβ.
title: DNA Damage Induction by Bilirubin Induced Oxidative Stress and Activation of DNA Repair Pathways by Bilirubin
Creators: name: Rawat, Vipin Singh
Publisher: name: The Open University
Year: 2018

description: “Kernicterus” due to hyperbilirubinemia is one of main cause of irreversible brain damage in low and middle income countries. Deaths due to “kernicterus” are ranked within the top 3 causes of neonatal death in African countries. Neonates experiencing permanent or temporary absence or reduced activity of Uridine diphosphate-glucuronosyl-transferase A1 (UGT1A1) enzyme present increased levels of total unconjugated bilirubin (UCB) in the blood. When the bilirubin binding capacity of serum albumin is saturated, this results in the increase in the free fraction of bilirubin (Bf). The excess of Bf is accumulated in lipid-rich tissues such as the brain, where it may reach toxic levels causing bilirubin-induced encephalopathy in jaundiced newborns and patients with Crigler-Najjar syndrome Type I, leading to kernicterus if not promptly treated. Bilirubin causes severe neurological dysfunction by affecting several different cellular pathways such as, induction of oxidative stress, endoplasmic reticulum (ER) stress, autophagy, neuroinflammation and DNA damage. The work done in this thesis focus on the DNA damaging effect of bilirubin on neuronal (SH SY 5Y) and non-neuronal (HeLa) cells and the effect of bilirubin on the different double stranded break (DSB) repair pathways was investigated using HeLa DR GFP and HeLa cell lines. Bilirubin exposure led to time-dependent increase in DNA damage in neuronal cells. Treatment with the anti-oxidant N-acetylcysteine (NAC) caused a dose-dependent decrease in DNA damage, suggesting a key role of oxidative stress in bilirubin-induced DNA damage. In the second part of this work, I studied the effect of bilirubin on different DSB repair pathways using HeLa cell lines. Treatment with bilirubin modulated Homologous Recombination (HR) in a time-dependent manner. In fact, treatment with different doses of bilirubin led to a dose-dependent increase in HR. Bilirubin-induced increase in HR was reversed by addition of NAC, suggesting the important role of oxidative stress in bilirubin-induced modulation of HR. DNA damage analysis after bilirubin treatment showed an increase in DNA damage in HeLa cells. Unexpectedly, bilirubin-induced DNA damage had no effect on the cell cycle profile. Similarly, exposure to bilirubin concentrations similar to those found in patients led to an increase in the Non-Homologous End Joining (NHEJ) pathway. These results suggest the general increase in DSB repair pathways by bilirubin.
Role of proton irradiation and relative air humidity on iron corrosion
Creators: name: Lapuerta, S.
name: Moncoffre, N.
name: Millard-Pinard, N.
name: Jaffrézic, H.
name: Bérerd, N.
name: Crusset, D.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: This paper presents a study of the effects of proton irradiation on iron corrosion. Since it is known that in humid atmospheres, iron corrosion is enhanced by the double influence of air and humidity, we studied the iron corrosion under irradiation with a 45% relative humidity. Three proton beam intensities (5, 10 and 20 nA) were used. To characterise the corrosion layer, we used ion beam methods (Rutherford Backscattering Spectrometry (RBS), Elastic Recoil Detection Analysis (ERDA)) and X-ray Diffraction (XRD) analysis. The corrosion kinetics are plotted for each proton flux. A diffusion model of the oxidant species is proposed, taking into account the fact that the flux through the surface is dependent on the kinetic factor K. This model provides evidence for the dependence of the diffusion coefficient, D, and the kinetic factor, K, on the proton beam intensity. Comparison of the values for D with the diffusion coefficients for thermal oxygen diffusion in iron at 300 K suggests an enhancement due to irradiation of 6 orders of magnitude.
Dynamical spin excitations of topological Haldane gapped phase in the $S=1$ Heisenberg antiferromagnetic chain with single-ion anisotropy
Creators: name: Huang, Jun-Han
name: Zhang, Guang-Ming
name: Yao, Dao-Xin
Publisher: name: arXiv
Year: 2020
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We study the dynamical spin excitations of the one-dimensional $S=1$ Heisenberg antiferromagnetic chain with single-ion anisotropy by using quantum Monte Carlo simulations and stochastic analytic continuation of imaginary-time correlation function. Using the transverse dynamic spin structure factor, we observe the quantum phase transition with a critical point between the topological Haldane gapped phase and the trivial phase. At the quantum critical point, we find a broad continuum characterized by the Tomonaga-Luttinger liquid similar to a $S=1/2$ Heisenberg antiferromagnetic chain. We further identify that the elementary excitations are fractionalized spinons.
description: 7 pages, 8 figures
Additional file 4 of The roles, activities and impacts of middle managers who function as knowledge brokers to improve care delivery and outcomes in healthcare organizations: a critical interpretive synthesis
Creators: name: Boutcher, Faith
name: Berta, Whitney
name: Urquhart, Robin
name: Gagliardi, Anna R.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 4. Data extraction form for eligible studies
Cost-optimal single-qubit gate synthesis in the Clifford hierarchy
Creators: name: Mooney, Gary J.
name: Hill, Charles D.
name: Hollenberg, Lloyd C. L.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: For universal quantum computation, a major challenge to overcome for practical implementation is the large amount of resources required for fault-tolerant quantum information processing. An important aspect is implementing arbitrary unitary operators built from logical gates within the quantum error correction code. A synthesis algorithm can be used to approximate any unitary gate up to arbitrary precision by assembling sequences of logical gates chosen from a small set of universal gates that are fault-tolerantly performable while encoded in a quantum error-correction code. However, current procedures do not yet support individual assignment of base gate costs and many do not support extended sets of universal base gates. We analysed cost-optimal sequences using an exhaustive search based on Dijkstra's pathfinding algorithm for the canonical Clifford+$T$ set of base gates and compared them to when additionally including $Z$-rotations from higher orders of the Clifford hierarchy. Two approaches of assigning base gate costs were used. First, costs were reduced to $T$-counts by recursively applying a $Z$-rotation catalyst circuit. Second, costs were assigned as the average numbers of raw (i.e. physical level) magic states required to directly distil and implement the gates fault-tolerantly. We found that the average sequence cost decreases by up to $54\pm 3\%$ when using the $Z$-rotation catalyst circuit approach and by up to $33\pm 2 \%$ when using the magic state distillation approach. In addition, we investigated observed limitations of certain assignments of base gate costs by developing an analytic model to estimate the proportion of sets of $Z$-rotation gates from higher orders of the Clifford hierarchy that are found within sequences approximating random target gates.
description: 19 pages, 7 figures