cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Type 1 diabetes and epilepsy in childhood and adolescence: Do glutamic acid decarboxylase autoantibodies play a role? Data from the German/Austrian/Swiss/Luxembourgian DPV Registry
Creators: name: De Sousa, Gideon John
name: Tittel, Sascha René
name: Häusler, Martin
name: Holterhus, Paul Martin
name: Berger, Gabriele
name: Holder, Martin
name: Kamrath, Clemens
name: Golembowski, Sven
name: Herrlinger, Silke
name: Holl, Reinhard Walter
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: children and adolescents
subject: glutamic acid decarboxylase autoantibodies
subject: severe hypoglycemia
subject: DDC 610 / Medicine & health
subject: Diabetes mellitus, Type 1
subject: Child
subject: Adolescent
subject: Epilepsy
subject: Celiac disease
subject: Autoimmunity
subject: Antibodies
subject: Risk factors
subject: Diabetes mellitus Typ 1
subject: Kind
subject: Jugend
subject: Epilepsie
subject: Zöliakie
subject: Risikofaktor

description: Abstract Aims We aimed to analyze the relationship between epilepsy and glutamic acid decarboxylase autoantibodies (GADA) in patients with type 1 diabetes mellitus (T1DM) and the impact of GADA on demographic, clinical, and metabolic data in T1DM patients with epilepsy. Methods We searched for patients with T1DM ≤20 years and GADA measurements, and within this group for patients with epilepsy. We formed groups: T1DM + Epilepsy + GADA positive; T1DM + Epilepsy + GADA negative; T1DM + GADA positive; T1DM + GADA negative. We used logistic regression to analyze the relationship between epilepsy and GADA with odds ratio adjusted for sex, duration of diabetes (DOD), and age at diabetes onset (ADO). We used logistic regression with odds ratio adjusted for DOD and ADO onset using epilepsy as a dependent variable and GADA, HbA1c, ketoacidosis, severe hypoglycemia (SH), sex, celiac disease, and autoimmune thyroiditis as independent variables. We conducted regression analyses adjusted for sex, DOD, and ADO to analyze differences in clinical/metabolic parameters between the groups. Results Epilepsy was not more frequent in GADA‐positive patients (GPP). Logistic regression including all patients with GADA measurements showed that hypoglycemia with coma (HC) correlated with epilepsy when compared to no SH. We found no differences in clinical and metabolic data between GPP and GADA‐negative patients (GNP) with epilepsy. SH occurred more often in GPP with epilepsy in comparison to GPP without epilepsy. GNP with epilepsy had a higher rate of HC than GPP without epilepsy. Conclusion We found no relationship between epilepsy and GADA. A relationship between T1DM and epilepsy might be explainable by SH.
title: Determinanten der Wahlbeteiligung bei Europaparlamentswahlen
Creators: name: Aichholzer, Julian
Year: 2009

description: Für moderne, repräsentative Demokratien stellt die institutionalisierte Form der Beteiligung an Wahlen immer noch die wichtigste Form der politischen Partizipation dar. Heute findet der demokratische Prozess ebenso auf supranationaler Ebene, im Rahmen von Wahlen zum Europäischen Parlament statt. Gleichzeitig ist jedoch die durchschnittliche Wahlbeteiligung bei Europaparlamentswahlen seit den ersten Wahlen im Jahr 1979 kontinuierlich gesunken und stagniert heute bei weniger als der Hälfte der Wahlberechtigten. Die zentralen Fragen dieser Arbeit lauten: Was bedeutet der Umstand geringer Wahlbeteiligung für eine Demokratie? Welche individuellen Determinanten machen die Wahlteilnahme aus? Die Arbeit geht somit der politischen als auch soziologischen Frage nach, wie gesellschaftliche Zielsetzungen zu Stande kommen und wer daran beteiligt ist. Ein theoretischer Abschnitt bietet zunächst einen Überblick über verschiedene Ansätze zur Erklärung von politischer Partizipation im Verhältnis von Individuum und Gesellschaft. Die besprochenen Ansätze betonen bspw. das Individuum in der Sozialstruktur bzw. in sozioökonomischen Rahmenbedingungen, das Individuum als Teil von Gruppen und seine Integration in die Gesellschaft sowie die sozialpsychologische Dimension und individuelle Motivationen. Aufbauend auf dem theoretischen Teil wird ein theoriegeleitetes, multivariates statistisches Modell (Strukturgleichungsmodell) erstellt. Im Zentrum der Arbeit steht schließlich eine empirische Analyse der Europaparlamentswahlen in Österreich im Jahr 2004, welche sich auf Daten einer Nachwahlbefragung im Rahmen der „European Election Studies“ stützt. Die empirischen Ergebnisse legen nahe, dass primär das persönliche Interesse an den Wahlen und der Grad der Informiertheit für die Teilnahme entscheidend sind. Weiters spielen bspw. die Stärke der Bindung an eine Partei und höherer sozioökonomischer Status einer Person eine fördernde Rolle. Die Conclusio appelliert abschließend an die Stärkung der Möglichkeit zur politischen Partizipation, um die demokratische Grundlage Europas zu sichern. Dies könnte etwa über eine effektivere Vermittlungsarbeit von Parteien und Massenmedien, breite politische Bildung sowie durch Einführung europaweiter Referenden erreicht werden.
title: MINTELL4EU; the European Minerals Yearbook
Creators: name: Deady ,  Eimear
name: Kumelj ,  Špela
name: Jørgensen ,  Lisbeth Flindt
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: The MINTELL4EU project builds upon previous European-wide mineral intelligence projects, including ORAMA, MICA, MINventory and particularly the Minerals Intelligence Network for Europe project (Minerals4EU). In this most recent iteration, we have surveyed European geological surveys and other relevant data sources for detailed information on European mineral production, trade, resource, reserve and exploration data. We present an updated electronic Minerals Yearbook, a snapshot of current European mineral intelligence. We will illustrate some preliminary data analysis of resources and reserves using baseline data from the previous survey in 2013. Time series analysis of production and trade data from 2013 will also be shown. We also present comparisons of European mineral data with global datasets for selected commodities essential to the net-zero carbon transition.
title: "Mit den Wölfen muss man heulen ..."
Creators: name: Kölbl-Baudisch, Lisa Maria
Year: 2009

description: Die nachfolgende Arbeit rekonstruiert Integrationsstrategien von Menschen die in den vergangenen drei Jahrzehnten nach Österreich gekommen sind. Zum besseren Verständnis der Studie werden zu Beginn einige klassische Theorien der Migration bzw. Integrationskonzepte vorgestellt, doch das Haupt-augenmerk liegt auf den individuellen Einstellungen und Leistungen der Ge-sprächspartnerInnen. Zitate aus den biographischen Interviews, die nach den Grundsätzen der quali-tativen Forschung als narrative Interviews geführt worden sind, verdeutlichen die Herausarbeitung und Beschreibung der Erwägungen, die den individuellen Handlungen zu Grunde gelegt waren. Untersucht wird, welche spezifischen Eigenleistungen und welche gesellschaft-lichen Strukturen maßgeblich den Integrationsprozess der Befragten förderten bzw. beschränken.
description: The subsequent paper is a reconstruction of integration strategies of people who have come to Austria in the past three decades. For better understanding some classical theories of migration and integration concepts are presented in the beginning. The main focus is on individual atti-tudes and performance of the dialogue partners. Citations from the biographical interviews, which have been carried out as nar-rative interviews according to the principles of qualitative research, illustrate the identification and description of the considerations the individual acts were based on. It is an investigation on which specific personal contributions and what social structures relevantly promote or restrict the integration process of people.
Adenosine receptor 2B activity promotes autonomous growth, migration as well as vascularization of head and neck squamous cell carcinoma cells
Creators: name: Wilkat, Max
name: Bast, Hanna
name: Drees, Robert
name: Dünser, Johannes
name: Mahr, Amelie
name: Azoitei, Ninel
name: Marienfeld, Ralf
name: Frank, Felicia
name: Brhel, Magnus
name: Ushmorov, Alexey
name: Greve, Jens
name: Goldberg‐Bockhorn, Eva
name: Theodoraki, Marie‐Nicole
name: Döscher, Johannes
name: Laban, Simon Andreas
name: Schuler, Patrick
name: Hoffmann, Thomas K.
name: Brunner, Cornelia
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: HNSCC
subject: ADORA2B
subject: CD39
subject: CD73
subject: CL-IB-MECA
subject: DDC 610 / Medicine & health
subject: Squamous cell carcinoma of head and neck
subject: Apoptosis
subject: Adenosine
subject: Endothelial cells
subject: Squamöser Krebs
subject: Krebszelle
subject: Adenosin
subject: Adenosinrezeptor

description: Adenosine is a signaling molecule that exerts dual effects on tumor growth: while it inhibits immune cell function and thereby prevents surveillance by the immune system, it influences tumorigenesis directly via activation of adenosine receptors on tumor cells at the same time. However, the adenosine‐mediated mechanisms affecting oncogenic processes particularly in head and neck squamous cell carcinomas (HNSCC) are not fully understood. Here, we investigated the role of adenosine receptor activity on HNSCC‐derived cell lines. Targeting the adenosine receptor A2B (ADORA2B) on these cells with the inverse agonist/antagonist PSB‐603 leads to inhibition of cell proliferation, transmigration as well as VEGFA secretion in vitro. At the molecular level, these effects were associated with cell cycle arrest as well as the induction of the apoptotic pathway. In addition, shRNA‐mediated downmodulation of ADORA2B expression caused decreased proliferation. Moreover, in in vivo xenograft experiments, chemical and genetic abrogation of ADORA2B activity impaired tumor growth associated with decreased tumor vascularization. Together, our findings characterize ADORA2B as a crucial player in the maintenance of HNSCC and, therefore, as a potential therapeutic target for HNSCC treatment.
description: What's new? The adenosinergic system plays an important role in the development of many types of cancer. However, the underlying mechanisms remain poorly understood. This study set to identify the oncogenic function of the adenosine receptor 2B (ADORA2B) in head and neck squamous cell carcinoma (HNSCC)‐derived tumor cells. The results show that ADORA2B is upregulated and constitutively active in HNSCC‐derived cell lines. This activity is sufficient to promote autonomous cell growth, migration, and angiogenesis in vitro and in vivo. The data suggest ADORA2B as an important biomarker and potential therapeutic target for the treatment of HNSCC and other ADORA2B‐expressing solid tumors.
Additional file 2 of Impact of residual microcalcifcations on prognosis after neoadjuvant chemotherapy in breast cancer patients
Creators: name: Kim, Eun Young
name: Lee, Kwan Ho
name: Yun, Ji-Sup
name: Park, Yong Lai
name: Park, Chan Heun
name: Jang, Sung Yoon
name: Ryu, Jai Min
name: Lee, Se Kyung
name: Chae, Byung-Joo
name: Lee, Jeong Eon
name: Kim, Seok Won
name: Nam, Seok Jin
name: Yu, Jong Han
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Hematology
subject: Plant Biology
subject: FOS: Biological sciences

description: Supplementary Material 2.
Fluorescence analysis of vitamin D receptor status of circulating tumor cells (CTCS) in breast cancer: from cell models to metastatic patients
Creators: name: Zhang, Xi
name: Hofmann, Simone
name: Rack, Brigitte
name: Harbeck, Nadia
name: Jeschke, Udo
name: Sixou, Sophie
Publisher: name: Universität Ulm
Year: 2017
Subjects: subject: vitamin D receptor
subject: circulating tumor cells
subject: breast cancer
subject: DDC 610 / Medicine & health
subject: Breast neoplasms
subject: Neoplastic cells, Circulating
subject: Neoplasm metastasis
subject: Vitamin D
subject: Receptors, Calcitriol
subject: Brustkrebs
subject: Tumorzelle
subject: Metastase

description: The Vitamin D receptor (VDR) expressed in normal breast tissue and breast tumors has been suggested as a new prognostic biomarker in breast cancer (BC). Besides, increasing evidence supports the view that the detection of circulating tumor cells (CTCs) predicts outcome in early and metastatic BC. Consequently, an evaluation of VDR expression in the CTCs of BC patients may allow optimization of their treatment. As an attempt to profile and subtype the CTCs of metastatic patients, we established an innovative fluorescence technique using nine BC cell lines to visualize, define, and compare their individual VDR status. Afterwards, we tested the CTC presence and VDR expression in blood samples (cytospins) collected from 23 metastatic BC patients. The results demonstrated major differences in the VDR levels among the nine cell lines, and VDR positive CTCs were detected in 46% of CTC-positive patients, with a total of 42 CTCs individually analyzed. Due to the limited number of patients in this study, no correlation between VDR expression and BC subtype classification (according to estrogen receptor (ER), progesterone receptor (PR) and HER2) could be determined, but our data support the view that VDR evaluation is a potential new prognostic biomarker to help in the optimization of therapy management for BC patients.
sj-docx-4-son-10.1177_23779608231218155 - Supplemental material for Survey of Guideline Compliance and Attitude Toward Symptom Management in Japanese Intensive Care Units
Creators: name: Yamada, Shuhei
name: Sakuramoto, Hideaki
name: Aikawa, Gen
name: Naya, Kazuaki
Publisher: name: SAGE Journals
Year: 2023
Subjects: Medicine
Nursing not elsewhere classified
Public Health and Health Services not elsewhere classified

description: Supplemental material, sj-docx-4-son-10.1177_23779608231218155 for Survey of Guideline Compliance and Attitude Toward Symptom Management in Japanese Intensive Care Units by Shuhei Yamada, Hideaki Sakuramoto and Gen Aikawa, Kazuaki Naya in SAGE Open Nursing
Additional file 3 of Impact of residual microcalcifcations on prognosis after neoadjuvant chemotherapy in breast cancer patients
Creators: name: Kim, Eun Young
name: Lee, Kwan Ho
name: Yun, Ji-Sup
name: Park, Yong Lai
name: Park, Chan Heun
name: Jang, Sung Yoon
name: Ryu, Jai Min
name: Lee, Se Kyung
name: Chae, Byung-Joo
name: Lee, Jeong Eon
name: Kim, Seok Won
name: Nam, Seok Jin
name: Yu, Jong Han
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Hematology
subject: Plant Biology
subject: FOS: Biological sciences

description: Supplementary Material 3.
Intact Glucocorticoid Receptor Dimerization Is Deleterious in Trauma-Induced Impaired Fracture Healing
Creators: name: Hachemi, Yasmine
name: Rapp, Anna Elise
name: Lee, Sooyeon
name: Dorn, Ann-Kristin
name: Krüger, Benjamin T.
name: Kaiser, Kathrin Nadine
name: Ignatius, Anita
name: Tuckermann, Jan
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: fracture
subject: thoracic trauma
subject: bone repair
subject: DDC 610 / Medicine & health
subject: Inflammation
subject: Receptors, Glucocorticoid
subject: Bone and bones
subject: Fracture healing
subject: Frakturheilung
subject: Knochen
subject: Entzündung
subject: Glucocorticosteroidrezeptor

description: Following severe trauma, fracture healing is impaired because of overwhelming systemic and local inflammation. Glucocorticoids (GCs), acting via the glucocorticoid receptor (GR), influence fracture healing by modulating the trauma-induced immune response. GR dimerization-dependent gene regulation is essential for the anti-inflammatory effects of GCs. Therefore, we investigated in a murine trauma model of combined femur fracture and thoracic trauma, whether effective GR dimerization influences the pathomechanisms of trauma-induced compromised fracture healing. To this end, we used mice with decreased GR dimerization ability (GRdim). The healing process was analyzed by cytokine/chemokine multiplex analysis, flow cytometry, gene-expression analysis, histomorphometry, micro-computed tomography, and biomechanical testing. GRdim mice did not display a systemic or local hyper-inflammation upon combined fracture and thorax trauma. Strikingly, we discovered that GRdim mice were protected from fracture healing impairment induced by the additional thorax trauma. Collectively and in contrast to previous studies describing the beneficial effects of intact GR dimerization in inflammatory models, we report here an adverse role of intact GR dimerization in trauma-induced compromised fracture healing.
Giorgione's discovery of Jupiter's four largest moons 105 years before Galileo Galilei
Creators: name: Keim, Frank
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: Ganymedes
subject: Io
subject: Jupiter
subject: Simon Marius
subject: DDC 500 / Natural sciences & mathematics
subject: Astronomy; 16th century
subject: Optics
subject: Optics. History
subject: Satellites. Jupiter
subject: Science. History
subject: Aristarchus
subject: Callisto
subject: Europa
subject: Fernrohr
subject: Heliozentrisches System
subject: Optik

description: In his 1508/09 painting "The three philosophers", Giorgio di Castelfranco (alias Giorgione) portrayed next to others Aristarchus of Samos, a great astronomer of his time. Almost as an aside, Giorgione’s painting captured a revolutionary discovery, which is shown on the document Aristarchus holds in front of his chest: the observation of Jupiter’s four largest moons, one hundred years before Galileo Galilei. (This paper is an extract from the enquiry "Giorgiones Entdeckung der vier großen Jupitermonde 105 Jahre vor Galileo Galilei" by the author, published at Ulm in 2005 via: http://vts.uni-ulm.de/doc.asp?id=5401).
Integration of the deacetylase SIRT1 in the response to nucleolar stress:metabolic implications for neurodegenerative diseases
Creators: name: Kreiner, Grzegorz
name: Sönmez, Aynur
name: Liß, Birgit
name: Parlato, Rosanna
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: nucleolus
subject: rRNA
subject: neuronal homeostasis
subject: neurodegeneration
subject: DDC 610 / Medicine & health
subject: Nervous system; Degeneration
subject: Neurodegenerative diseases
subject: Sirtuins
subject: Oxidative stress
subject: RNA, Ribosomal
subject: Nervendegeneration
subject: Sirtuine
subject: Oxidativer Stress
subject: Ribosomale RNS
subject: Protein p53

description: Understanding underlying mechanisms of neurodegenerative diseases is fundamental to develop effective therapeutic intervention. Yet they remain largely elusive, but metabolic, and transcriptional dysregulation are common events. Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NADC)-dependent lysine deacetylase, regulating transcription, and critical for the cellular adaptations to metabolic stress. SIRT1 regulates the transcription of ribosomal RNA (rRNA), connecting the energetic state with cell growth and function. The activity of the transcription initiation factor-IA (TIF-IA) is important for the transcriptional regulation of ribosomal DNA (rDNA) genes in the nucleolus, and is also sensitive to changes in the cellular energetic state. Moreover, TIF-IA is responsive to nutrient-deprivation, neurotrophic stimulation, and oxidative stress. Hence, both SIRT1 and TIF-IA connect changes in cellular stress with transcriptional regulation and metabolic adaptation. Moreover, they finely tune the activity of the transcription factor p53, maintain mitochondrial function, and oxidative stress responses. Here we reviewed and discussed evidence that SIRT1 and TIF-IA are regulated by shared pathways and their activities preserve neuronal homeostasis in response to metabolic stressors. We provide evidence that loss of rDNA transcription due to altered TIF-IA function alters SIRT1 expression and propose a model of interdependent feedback mechanisms. An imbalance of this signaling might be a critical common event in neurodegenerative diseases. In conclusion, we provide a novel perspective for the prediction of the therapeutic benefits of the modulation of SIRT1- and nucleolar-dependent pathways in metabolic and neurodegenerative diseases.
Communications Specifications Plan - D7.1 Invade H2020
Creators: name: Cordobés, Cristóbal
Publisher: name: Zenodo
Year: 2017
Subjects: INVADE
Flexibility
Smart Grids
H2020
Electric vehicles
Batteries

description: The deliverable examines the communication requirements of the envisaged INVADE communication Layer establishing the steps and baseline to be followed in the next tasks and WPs related with the Pilot developments, regarding all communications.

The document presents the communication use cases that will be required by the Business Process Layer (BPL) to control all relevant devices involved. The communication use cases shall be based on a high-level architect model known as Smart Grid Architecture Model (SGAM).
Additional file 4 of Impact of residual microcalcifcations on prognosis after neoadjuvant chemotherapy in breast cancer patients
Creators: name: Kim, Eun Young
name: Lee, Kwan Ho
name: Yun, Ji-Sup
name: Park, Yong Lai
name: Park, Chan Heun
name: Jang, Sung Yoon
name: Ryu, Jai Min
name: Lee, Se Kyung
name: Chae, Byung-Joo
name: Lee, Jeong Eon
name: Kim, Seok Won
name: Nam, Seok Jin
name: Yu, Jong Han
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Hematology
subject: Plant Biology
subject: FOS: Biological sciences

description: Supplementary Material 4.
title: Burnout Prävention für Betreuerinnen und Betreuer autistisch behinderter Menschen
Creators: name: Schörghuber, Oliver
Year: 2009

description: Betreuer autistisch behinderter Menschen sind auf Grund der Eigenheiten ihrer Klienten spezifischen Herausforderungen und hohen Belastungen ausgesetzt. Diese Herausforderungen und Belastungen können zu einem erhöhten Energiebedarf führen und in Folge ein Burnout verursachen. Damit die hohen Herausforderungen und Belastungen nicht zu einem Burnout für die Betreuer autistisch behinderter Menschen führen, müssen geeignete Maßnahmen zur Vorbeugung von Burnout gesetzt werden. In der bisherigen Fachliteratur findet das Themenfeld der Burnout Prävention unzureichend, für Betreuer autistischer Menschern überhaupt keine Bearbeitung. Daher ist das Anliegen der vorliegenden Arbeit, Maßnahmen zur Burnout Prävention für Betreuer autistisch behinderter Menschen aufzuzeigen. Das Aufzeigen von präventiven Maßnahmen erfordert die theoretische Auseinandersetzung mit dem Krankheitsbild des Autismus, den Eigenheiten von autistischen Menschen und den Belastungen für ihre Betreuer. Im Weiteren folgt die Aufarbeitung von Burnout, der Ursachen von Burnout und den theoretischen Erklärungsmodellen. Das Aufzeigen präventiver Maßnahmen zur Vorbeugung von Burnout für autistisch behinderte Menschen schließt die theoretischen Ausführungen. Um die Aussagen über Burnout Prävention für Betreuer autistisch behinderter Menschen zu vertiefen bzw. zu veranschaulichen, wurden Interviews mit Betreuern autistisch behinderter Menschen durchgeführt.
Effort considerations of compressed sensing for automotive radar
Creators: name: Roos, Fabian
name: Hügler, Philipp
name: Bechter, Jonathan
name: Razzaq, Muhammad Ahsan
name: Knill, Christina
name: Appenrodt, Nils
name: Dickmann, Jürgen
name: Waldschmidt, Christian
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: Automotive radar
subject: Effort
subject: Interference mitigation
subject: DDC 620 / Engineering & allied operations
subject: Compressed sensing (Telecommunication)
subject: Radar
subject: MIMO systems
subject: Signal processing
subject: Data reduction
subject: Komprimierte Abtastung
subject: Radar
subject: MIMO
subject: Signalverarbeitung

description: The application of iterative compressed sensing algorithms for automotive radar is often considered as too complex for real-time evaluation. In this paper, it is shown that the number of required iterations can be chosen considerable low. To determine the necessary steps, a quality criterion is evaluated. The two examined scenarios are a reduced data rate and an interference mitigation. Measurement results are shown for different numbers of iterations to verify the sufficient reconstruction capabilities.
sj-docx-1-whe-10.1177_17455057231213272 – Supplemental material for Maternal and umbilical cord blood levels of leptin in pre-eclamptic and healthy pregnant women: A comparative cross-sectional study
Creators: name: Okafor, Lazarus Ugochukwu
name: Eleje, George Uchenna
name: Ikechebelu, Joseph Ifeanyichukwu
name: Ugwu, Emmanuel Onyebuchi
name: Nwosu, Obi Betrand
name: Ikpeze, Okechukwu Christian
name: Udigwe, Gerald Okanandu
name: Eke, Ahizechukwu Chigoziem
name: Okoli, Samuel A
name: Oguejiofor, Charlotte Blanche
name: Ogabido, Chukwudi Anthony
name: Malachy, Divinefavour Echezona
name: Ofor, Ifeanyichukwu Jude
name: Okafor, Chigozie Geoffrey
Publisher: name: SAGE Journals
Year: 2023
Subjects: Obstetrics and Gynaecology

description: Supplemental material, sj-docx-1-whe-10.1177_17455057231213272 for Maternal and umbilical cord blood levels of leptin in pre-eclamptic and healthy pregnant women: A comparative cross-sectional study by Lazarus Ugochukwu Okafor, George Uchenna Eleje, Joseph Ifeanyichukwu Ikechebelu, Emmanuel Onyebuchi Ugwu, Obi Betrand Nwosu, Okechukwu Christian Ikpeze, Gerald Okanandu Udigwe, Ahizechukwu Chigoziem Eke, Samuel A Okoli, Charlotte Blanche Oguejiofor, Chukwudi Anthony Ogabido, Divinefavour Echezona Malachy, Ifeanyichukwu Jude Ofor and Chigozie Geoffrey Okafor in Women’s Health
Additional file 1 of Elucidation of the genetic determination of body weight and size in Chinese local chicken breeds by large-scale genomic analyses
Creators: name: Wang, Jie
name: Liu, Jie
name: Lei, Qiuxia
name: Liu, Zhihe
name: Han, Haixia
name: Zhang, Shuer
name: Qi, Chao
name: Liu, Wei
name: Li, Dapeng
name: Li, Fuwei
name: Cao, Dingguo
name: Zhou, Yan
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 1
The effects of childhood maltreatment on epigenetic regulation of stress-response associated genes: an intergenerational approach
Creators: name: Ramo-Fernández, Laura
name: Böck, Christina
name: König, Alexandra M.
name: Schury, Katharina
name: Binder, Elisabeth B.
name: Gündel, Harald
name: Fegert, Jörg M.
name: Karabatsiakis, Alexander
name: Kolassa, Iris-Tatjana
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: Gene regulation
subject: Translational immunology
subject: DDC 150 / Psychology
subject: DDC 570 / Life sciences
subject: Epigenetics
subject: Genetic regulation
subject: Epigenomics
subject: Psychology
subject: FOS: Psychology
subject: Epigenetik
subject: Genregulation
subject: Genexpression
subject: Immunologie

description: While biological alterations associated with childhood maltreatment (CM) have been found in affected individuals, it remains unknown to what degree these alterations are biologically transmitted to the next generation. We investigated intergenerational effects of maternal CM on DNA methylation and gene expression in N = 113 mother-infant dyads shortly after parturition, additionally accounting for the role of the FKBP5 rs1360780 genotype. Using mass array spectrometry, we assessed the DNA methylation of selected stress-response-associated genes (FK506 binding protein 51 [FKBP5], glucocorticoid receptor [NR3C1], corticotropin-releasing hormone receptor 1 [CRHR1]) in isolated immune cells from maternal blood and neonatal umbilical cord blood. In mothers, CM was associated with decreased levels of DNA methylation of FKBP5 and CRHR1 and increased NR3C1 methylation, but not with changes in gene expression profiles. Rs1360780 moderated the FKBP5 epigenetic CMassociated regulation profiles in a gene × environment interaction. In newborns, we found no evidence for any intergenerational transmission of CM-related methylation profiles for any of the investigated epigenetic sites. These findings support the hypothesis of a long-lasting impact of CM on the biological epigenetic regulation of stress-response mediators and suggest for the first time that these specific epigenetic patterns might not be directly transmitted to the next generation.
title: Gewalt der Gefühle
Creators: name: Themel, Sarah Magdalena
Year: 2009

description: Sigmund Freud setzt sich in einem seiner Briefe an Albert Einstein mit der Frage „Warum Krieg?“ kulturtheoretisch auseinander. Eine seiner Thesen darin lautet: „Wir haben gehört, was eine Gemeinschaft zusammenhält, sind zwei Dinge: der Zwang der Gewalt und die Ge-fühlsbindungen – Identifizierungen heißt man sie technisch – der Mitglieder.“ Gewalt und Gefühlsbindungen sind es auch welche man als die thematischen Maxime des Heldenepos Dietrichs Flucht bezeichnen könnte. Ein Kreislauf der Gewalttätigkeiten, welcher seine Hö-hepunkte in kriegerischen Aktivitäten in nahezu regelmäßigen Abständen erreicht, dabei gleichzeitig verschiedene Ebenen von Emotion freilegt, erscheint als das ambiguitäre Moment jener Dichtung. Versucht wurde die Notwendigkeit, in Anbetracht der Entwicklung der Figu-ren sowie einer kritischen Auseinandersetzung mit dem Kriegsbegriff, jenes gewalttätigen Kreislaufs, unter Beweis zu stellen. Eine kulturgeschichtliche Skizzierung des Krieges im Mittelalter dient als Hintergrund einer sich auf Schlachtgeschehen und personalen Bindungen konzentrierenden Textanalyse, welche den Hauptteil dieser Arbeit bildet. Mittels der getroffenen Analyse soll ein umfassendes Bild der Entwicklung von Krieg und damit einhergehend von Emotionalität im Werk wiedergege-ben werden. Abschließend werden Möglichkeiten einer gewandelten Wahrnehmung von Krieg, Gemeinschaft und Identität verhandelt. Das Leid des Krieges und damit das Leiden der Figuren sollen einen möglichen Ausblick auf die Phantasie vom friedlichen Miteinander freigeben. Die herausragende Melancholie des Helden Dietrich scheint derartigen Theorien Recht zu geben. Der Krieg in Dietrichs Flucht soll als Basis des Werkes bewiesen werden. Diese Arbeit seine Bedeutsamkeit hinterfragen, interpretieren und damit gleichzeitig in den Vordergrund rücken.
High quality of life reduces depression, hopelessness, and suicide ideations in patients in forensic psychiatry
Creators: name: Büsselmann, Michael
name: Nigel, Stefanie
name: Otte, Stefanie
name: Lutz, Maximilian
name: Franke, Irina
name: Dudeck, Manuela
name: Streb, Judith
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Social conditions
subject: Hopelessness
subject: DDC 150 / Psychology
subject: Forensic psychiatry
subject: Quality of life
subject: Depression
subject: Suicidal deation
subject: Suicide
subject: Gerichtliche Psychiatrie
subject: Lebensqualität
subject: Selbstmordgefährdung

description: Background Suicides are more common in forensic patients than in the general population. Two reasons for this discrepancy are discussed: (1) Suicides are the consequence of maladaptation to the restrictive living conditions in forensic psychiatry, and (2) suicides are explained by the demographic, social, and psychosocial characteristics of the inmates themselves, i.e., suicides happen because the inmates belong to a particularly vulnerable group. Therefore, the present study aimed to analyze the relationship between quality of life, as an indicator of the restrictive living conditions, and hopelessness, depression, and suicide ideations in a sample of forensic patients. Methods We assessed quality of life with a German version of the Measuring the Quality of Prison Life questionnaire that had been adapted to forensic hospitals (MQPL-forensic) and depressive symptoms with the Beck Depression Inventory, hopelessness with the Beck Hopelessness Scale, and suicide ideations with the Beck Scale for Suicide Ideation. The study included a total of 159 patients in 12 German forensic psychiatric hospitals who had been admitted in accordance with Section 64 of the German Criminal Code. We analyzed the relationships between quality of life and depression, hopelessness, and suicide ideations on the patient and hospital levels. Hospital characteristics were generated by aggregating the MQPL-forensic variables measured at the patient level. Results In generalized estimating equation models, the MQPL-forensic total score and almost all the subscale scores were significant negative predictors of depressive symptoms, hopelessness, and suicide ideations at the patient and hospital levels. At the patient level, patients who experienced a supportive welcome at the hospital, good relationships with their therapists, respectful interactions, transparent decisions, and supportive therapeutic approaches were significantly less depressed, less hopeless, and less likely to consider suicide. At the hospital level, good relationships with therapists and respectful interactions were significant negative predictors of these variables. Discussion The results indicate that the social framework within forensic psychiatric hospitals influences the frequency of suicide ideation and the severity of depressive symptoms and hopelessness among forensic patients. Forensic-psychiatric hospitals should be aware of these significant relationships and try to improve patients’ quality of life.
Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A consensus statement
Creators: name: Hegen, Harald
name: Arrambide, Georgina
name: Gnanapavan, Sharmilee
name: Kaplan, Batia
name: Khalil, Michael
name: Saadeh, Ruba
name: Teunissen, Charlotte
name: Tumani, Hayrettin
name: Villar, Luisa Maria
name: Willrich, Maria Alice V
name: Zetterberg, Henrik
name: Deisenhammer, Florian
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: Cerebrospinal fluid
subject: kappa-free light chains
subject: multiple sclerosis
subject: clinically isolated syndrome
subject: diagnosis
subject: disease activity
subject: prediction
subject: biomarker
subject: index
subject: consensus
subject: N LATEX FLC
subject: BIOLOGICAL VARIATION
subject: FLOW-RATE
subject: CSF
subject: PERFORMANCE
subject: SERUM
subject: VALIDATION
subject: GUIDELINES
subject: DDC 610 / Medicine & health

description: Cerebrospinal fluid (CSF) analysis is of utmost importance for diagnosis and differential diagnosis of patients with suspected multiple sclerosis (MS). Evidence of intrathecal immunoglobulin G (IgG) synthesis proves the inflammatory nature of the disease, increases diagnostic certainty and substitutes for dissemination in time according to current diagnostic criteria. The gold standard to determine intrathecal IgG synthesis is the detection of CSF-restricted oligoclonal bands (OCBs). However, advances in laboratory methods brought up κ-free light chains (FLCs) as a new biomarker, which are produced in excess over intact immunoglobulins and accumulate in CSF in the case of central nervous system-derived inflammation. Overwhelming evidence showed a high diagnostic accuracy of intrathecal κ-FLC synthesis in MS with sensitivity and specificity of approximately 90% similar to OCB. κ-FLCs have advantages as its detection is fast, easy, cost-effective, reliable, rater-independent and returning quantitative results which might also improve the value of predicting MS disease activity. An international panel of experts in MS and CSF diagnostics developed a consensus of all participants. Six recommendations are given for establishing standard CSF evaluation in patients suspected of having MS. The panel recommended to include intrathecal κ-FLC synthesis in the next revision of MS diagnostic criteria as an additional tool to measure intrathecal immunoglobulin synthesis.
Supplemental Material - Yoga Plus Mantram Repetition to Reduce Chronic Pain in Veterans With Post-Traumatic Stress Disorder: A Feasibility Trial
Creators: name: Groessl, Erik J.
name: Hafey, Carol
name: McCarthy, Adhana
name: Hernandez, Rahil M.
name: Prado-Nava, Miguel
name: Casteel, Danielle
name: McKinnon, Symone
name: Chang, Douglas G.
name: Ayers, Catherine R.
name: Rutledge, Thomas R.
name: Lang, Ariel J.
name: Bormann, Jill E.
Publisher: name: SAGE Journals
Year: 2023
Subjects: Health and Community Services
Medicine
Public Health and Health Services not elsewhere classified

description: Supplemental Material for Yoga Plus Mantram Repetition to Reduce Chronic Pain in Veterans With Post-Traumatic Stress Disorder: A Feasibility Trial by Erik J. Groessl, Carol L. Hafey, Adhana McCarthy, Rahil M. Hernandez, Miguel Prado-Nava, Danielle Casteel, Symone McKinnon, Douglas G. Chang, Catherine R. Ayers, Thomas R. Rutledge, Ariel J. Lang, and Jill E. Bormann in Global Advances in Integrative Medicine and Health
NeuroExercise: The Effect of a 12-Month Exercise Intervention on Cognition in Mild Cognitive Impairment—A Multicenter Randomized Controlled Trial
Creators: name: Stuckenschneider, Tim
name: Sanders, Marit L.
name: Devenney, Kate E.
name: Aaronson, Justine A.
name: Abeln, Vera
name: Claassen, Jurgen A. H. R.
name: Guinan, Emer
name: Lawlor, Brian
name: Meeusen, Romain
name: Montag, Christian
name: Olde Rikkert, Marcel G. M.
name: Polidori, M. Cristina
name: Reuter, Martin
name: Schulz, Ralf-Joachim
name: Vogt, Tobias
name: Weber, Bernd
name: Kessels, Roy P. C.
name: Schneider, Stefan
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Alzheimer's disease
subject: non-pharmacological treatment
subject: aerobic exercise
subject: DDC 150 / Psychology
subject: DDC 610 / Medicine & health
subject: Alzheimer disease
subject: Cognition
subject: Cognitive dysfunction
subject: Complementary therapies
subject: Exercise
subject: Quality of life
subject: Alzheimerkrankheit
subject: Kognition
subject: Alternative Medizin
subject: Lebensqualität

description: Exercise intervention studies in mild cognitive impairment (MCI), a prodromal stage of Alzheimer's disease (AD), have demonstrated inconsistent yet promising results. Addressing the limitations of previous studies, this trial investigated the effects of a 12-month structured exercise program on the progression of MCI. The NeuroExercise study is a multicenter randomized controlled trial across three European countries (Ireland, Netherlands, Germany). Hundred and eighty-three individuals with amnestic MCI were included and were randomized to a 12-month exercise intervention (3 units of 45 min) of either aerobic exercise (AE; n = 60), stretching and toning exercise (ST; n = 65) or to a non-exercise control group (CG; n = 58). The primary outcome, cognitive performance, was determined by an extensive neuropsychological test battery. For the primary complete case (CC) analyses, between-group differences were analyzed with analysis of covariance under two conditions: (1) the exercise group (EG = combined AE and ST groups) compared to the CG and (2) AE compared to ST. Primary analysis of the full cohort (n = 166, 71.5 years; 51.8% females) revealed no between-group differences in composite cognitive score [mean difference (95% CI)], 0.12 [(−0.03, 0.27), p = 0.13] or in any cognitive domain or quality of life. VO2 peak was significantly higher in the EG compared to the CG after 12 months [−1.76 (−3.39, −0.10), p = 0.04]. Comparing the two intervention groups revealed a higher VO2peak level in the aerobic exercise compared to the stretching and toning group, but no differences for the other outcomes. A 12-month exercise intervention did not change cognitive performance in individuals with amnestic MCI in comparison to a non-exercise CG. An intervention effect on physical fitness was found, which may be an important moderator for long term disease progression and warrants long-term follow-up investigations. Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT02913053, identifier: NCT02913053.
Additional file 1 of Genome sequencing and analysis of black flounder (Paralichthys orbignyanus) reveals new insights into Pleuronectiformes genomic size and structure
Creators: name: Villarreal, Fernando
name: Burguener, Germán F.
name: Sosa, Ezequiel J.
name: Stocchi, Nicolas
name: Somoza, Gustavo M.
name: Turjanski, Adrián G.
name: Blanco, Andrés
name: Viñas, Jordi
name: Mechaly, Alejandro S.
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary material 1.
sj-docx-1-wso-10.1177_17474930231222163 – Supplemental material for Plateauing atrial fibrillation burden in acute ischemic stroke admissions in the United States from 2010 to 2020
Creators: name: Otite, Fadar Oliver
name: Patel, Smit D
name: Aneni, Ehimen
name: Lamikanra, Oluwatomi
name: Wee, Claribel
name: Albright, Karen C
name: Burke, Devin
name: Latorre, Julius Gene
name: Morris, Nicholas Allen
name: Anikpezie, Nnabuchi
name: Singla, Amit
name: Sonig, Ashish
name: Kamel, Hooman
name: Khandelwal, Priyank
name: Chaturvedi, Seemant
Publisher: name: SAGE Journals
Year: 2024
Subjects: subject: Cardiology
subject: Medicine
subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine

description: Supplemental material, sj-docx-1-wso-10.1177_17474930231222163 for Plateauing atrial fibrillation burden in acute ischemic stroke admissions in the United States from 2010 to 2020 by Fadar Oliver Otite, Smit D Patel, Ehimen Aneni, Oluwatomi Lamikanra, Claribel Wee, Karen C Albright, Devin Burke, Julius Gene Latorre, Nicholas Allen Morris, Nnabuchi Anikpezie, Amit Singla, Ashish Sonig, Hooman Kamel, Priyank Khandelwal and Seemant Chaturvedi in International Journal of Stroke
Supplemental Material - Factors Associated With Fatigue in Persons With Atrial Fibrillation in the Atherosclerosis Risk in Communities (ARIC) Study
Creators: name: Wood, Kathryn A.
name: Alam, Aniqa B.
name: Chen, Lin Yee
name: Soliman, Elsayed Z.
name: Quyyumi, Arshed A.
name: Alonso, Alvaro
Publisher: name: SAGE Journals
Year: 2024
Subjects: Nursing not elsewhere classified

description: Supplemental Material for Factors Associated With Fatigue in Persons With Atrial Fibrillation in the Atherosclerosis Risk in Communities (ARIC) Study by Kathryn A. Wood, PhD, RN, Aniqa B. Alam, MPH, Lin Yee Chen, MD, MS, Elsayed Z. Soliman, MD, MSc, MS, Arshed A. Quyyumi, MD, and Alvaro Alonso, MD, PhD in Biological Research For Nursing.
Dataset & Syntax for paper "It’s a challenge! Empathizing with sad but not with angry individuals results in cardiovascular reactivity consistent with a challenge motivational state"
Creators: name: (:Unkn) Unknown
Publisher: name: Universität Ulm
Year: 2018
Subjects: subject: physiologische Daten
subject: Forschungsdaten
subject: Experimentalablauf
subject: DDC 150 / Psychology
subject: Sadness
subject: Anger
subject: Emotions

description: This dataset contains data and a sytax for the data described in the following article "It’s a challenge! Empathizing with sad but not with angry individuals results in cardiovascular reactivity consistent with a challenge motivational state". Moreover, it contains a pdf document describing the exerimental procedures.
sj-pdf-1-jse-10.1177_15270025231222632 - Supplemental material for Should I Stay or Should I Go Pro? Early NFL Draft Entry by NCAA FBS Underclassmen
Creators: name: Humphreys, Brad R.
name: Chikish, Yulia
name: von Allmen, Peter
Publisher: name: SAGE Journals
Year: 2024
Subjects: Economics
Organisation and Management Theory

description: Supplemental material, sj-pdf-1-jse-10.1177_15270025231222632 for Should I Stay or Should I Go Pro? Early NFL Draft Entry by NCAA FBS Underclassmen by Brad R. Humphreys, Yulia Chikish and Peter von Allmen in Journal of Sports Economics
SOD2ako mouse displays a psychotic moment.
Creators: name: (:Unkn) Unknown
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: psychotic moment
subject: DDC 610 / Medicine & health
subject: Affective Disorders, Psychotic
subject: Psychotiker

description: Representative video of a SOD2ako mouse displaying a psychotic moment. Left: SOD2ako mouse, Right: WT mouse.
sj-docx-4-dhj-10.1177_20552076231223801 - Supplemental material for ‘It's not everybody's snapshot. It's just an insight into that world’: A qualitative study of multiple perspectives towards understanding the mental health experience and addressing stigma in healthcare students through virtual reality
Creators: name: Szekely, Raul
name: Mason, Oliver
name: Frohlich, David
name: Barley, Elizabeth
Publisher: name: SAGE Journals
Year: 2024
Subjects: subject: Health and Community Services
subject: Cardiology
subject: Endocrinology
subject: Geriatrics and Gerontology
subject: Nursing not elsewhere classified
subject: Oncology and Carcinogenesis not elsewhere classified
subject: Aged Health Care
subject: Public Health and Health Services not elsewhere classified
subject: Engineering not elsewhere classified
subject: Anthropology
subject: FOS: Sociology
subject: Cultural Studies not elsewhere classified
subject: Information and Computing Sciences not elsewhere classified
subject: Organisation and Management Theory
subject: Science Policy
subject: Social Policy
subject: Sociology

description: Supplemental material, sj-docx-4-dhj-10.1177_20552076231223801 for ‘It's not everybody's snapshot. It's just an insight into that world’: A qualitative study of multiple perspectives towards understanding the mental health experience and addressing stigma in healthcare students through virtual reality by Raul Szekely, Oliver Mason, David Frohlich and Elizabeth Barley in DIGITAL HEALTH
How do technologies support School Direct students' learning on a
      PGCE with Qualified Teacher Status within a Networked Learning Model
Creators: name: Toyn, Mike
Publisher: name: Lancaster University
Year: 2018

description: This work is a study of the way that students select and use technologies
      to build and maintain a learning network while training to become primary
      school teachers. It builds on the body of research which has explored
      Networked Learning by applying it to the context of teacher education and
      by applying it to a course where the ICTs used are selected by students
      not provided by tutors.

      It is a case study based on intrinsic interest with an exploratory focus
      to understand how and why students make use of the technologies they
      select. It uses multiple data sources including group interviews with
      students, interviews with tutors, questionnaires, virtual learning
      environment data and transcripts of students’ social media interactions.
      The analysis of these has been performed along three lines of enquiry to
      establish who is talking to whom, what they are talking about and why they
      are talking about it.

      The findings bring together a novel approach to the application of
      Networked Learning and research into a new route into teaching and show
      that students are sophisticated and agile users of a range of
      technologies. They use a variety of technologies to build and support
      interactions with artefacts, tutors and other learners. Where there are
      constraints in place, such as tutors’ preference for face-to-face
      interactions there is evidence that students will make use of technologies
      to substitute other interactions in their place. It finds that students’
      most extensive interactions take place with other students and that these
      are multifaceted combining interactions directly related to learning,
      around-task interactions and social elements.

      It builds on research done in blended learning, networked learning,
      teacher education and social aspects of learning. It will be of interest
      to those interested in the role of technologies in education or those
      involved in teacher education.