cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Applicability of liquid biopsies to represent the mutational profile of tumor tissue from different cancer entities
Creators: name: Liebs, Sandra
name: Eder, Theresa
name: Klauschen, Frederick
name: Schütte, Moritz
name: Yaspo, Marie-Laure
name: Keilholz, Ulrich
name: Tinhofer, Ingeborg
name: Kidess-Sigal, Evelyn
name: Braunholz, Diana
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: liquid biopsies
subject: mutational profile
subject: tumor tissue
subject: cancer entities
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Genetic investigation of tumor heterogeneity and clonal evolution in solid cancers could be assisted by the analysis of liquid biopsies. However, tumors of various entities might release different quantities of circulating tumor cells (CTCs) and cell-free DNA (cfDNA) into the bloodstream, potentially limiting the diagnostic potential of liquid biopsy in distinct tumor histologies. Patients with advanced colorectal cancer (CRC), head and neck squamous cell carcinoma (HNSCC), and melanoma (MEL) were enrolled in the study, representing tumors with different metastatic patterns. Mutation profiles of cfDNA, CTCs, and tumor tissue were assessed by panel sequencing, targeting 327 cancer-related genes. In total, 30 tissue, 18 cfDNA, and 7 CTC samples from 18 patients were sequenced. Best concordance between the mutation profile of tissue and cfDNA was achieved in CRC and MEL, possibly due to the remarkable heterogeneity of HNSCC (63%, 55% and 11%, respectively). Concordance especially depended on the amount of cfDNA used for library preparation. While 21 of 27 (78%) tissue mutations were retrieved in high-input cfDNA samples (30-100 ng, N = 8), only 4 of 65 (6%) could be detected in low-input samples (<30 ng, N = 10). CTCs were detected in 13 of 18 patients (72%). However, downstream analysis was limited by poor DNA quality, allowing targeted sequencing of only seven CTC samples isolated from four patients. Only one CTC sample reflected the mutation profile of the respective tumor. Private mutations, which were detected in CTCs but not in tissue, suggested the presence of rare subclones. Our pilot study demonstrated superiority of cfDNA- compared to CTC-based mutation profiling. It was further shown that CTCs may serve as additional means to detect rare subclones possibly involved in treatment resistance. Both findings require validation in a larger patient cohort.
Experiences and Perceived Effects of Rosary Praying: A Qualitative Study
Creators: name: Stöckigt, Barbara
name: Jeserich, Florian
name: Walach, H.
name: Elies, M.
name: Brinkhaus, Benno
name: Teut, Michael
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Rosary
subject: Praying
subject: Well-being
subject: Spirituality
subject: Qualitative research
subject: Coping
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The aim of this study is to explore experiences and perceived effects of the Rosary on issues around health and well-being, as well as on spirituality and religiosity. A qualitative study was conducted interviewing ten Roman Catholic German adults who regularly practiced the Rosary prayer. As a result of using a tangible prayer cord and from the rhythmic repetition of prayers, the participants described experiencing stability, peace and a contemplative connection with the Divine, with Mary as a guide and mediator before God. Praying the Rosary was described as helpful in coping with critical life events and in fostering an attitude of acceptance, humbleness and devotion.
ELIXIR-STEERS M3.3 Use cases for benchmarking workflows identified
Creators: name: Batut, Bérénice
name: Ben-Avraham, Dan
name: Capella-Gutierrez, Salvador
name: Carazo, Jose Maria
name: Fernandez, Jose Maria
name: Golobardes Vilarasau, Anna
name: Mehdiabadi, Mahta
name: Piovesan, Damiano
name: Redondo, Ana
name: Sanchez de Lara, Lola
name: Schwämmle, Veit
name: Tosatto, Silvio
name: Yahalomi, Dayana
name: Zierep, Paul
Publisher: name: Zenodo
Year: 2025
Subjects: ELIXIR-STEERS
OpenEBench
Workflows

description: In the framework of ELIXIR-STEERS, task 3.3 aims to extend the OpenEBench community-led evaluation feature. This extension will enable the technical benchmarking of workflows used for common analyses in the Life Sciences domain based on reference datasets.

For that purpose, from the ELIXIR-STEERS Task 3.3 perspective, a software has been developed to obtain a set of technical metrics. Such metrics should enable the assessment of efficiency and environmental impact of software executions. This software is the Execution Metrics Collector, which gathers low-level technical metrics from Linux processes, which are then used to derive high-level indicators, including computational carbon footprint estimations. The Technical Metrics live document describes the low and high-level community-led metrics.

The identification of use cases for benchmarking workflows has been carried out in collaboration with ELIXIR-STEERS WP2, several ELIXIR Communities and other relevant Life Sciences communities, and is presented in Milestone 3.3 report. From the use cases identified, we will obtain low- and high-level metrics that will enable assessing the workflow executions' carbon footprint impact. We will connect those workflows with popular managers systems like Galaxy to gather usage. Altogether will provide us with valuable information about reproducibility and the reuse of workflows by the different scientific communities in ELIXIR and, potentially, beyond.
title: Behring, Emil von
title: Catalogus Professorum Halensis
titleType: Subtitle
title: Biografienportal Sachsen-Anhalt
titleType: Other
Creators: name: Catalogus Professorum Halensis
name: Eberle, Henrik
Publisher: name: Historisches Datenzentrum Sachsen-Anhalt,Institut für Landesgeschichte (Sachsen-Anhalt)
Year: 2025
Subjects: subject: History
classificationCode: 4023025-9
subject: Halle (Saale)
valueUri: https://d-nb.info/gnd/4023025-9
classificationCode: 4006804-3
subject: Biografie
valueUri: https://d-nb.info/gnd/4006804-3
classificationCode: 4166546-6
subject: Landesgeschichte
valueUri: https://d-nb.info/gnd/4166546-6
classificationCode: 4051181-9
subject: Sachsen-Anhalt
valueUri: https://d-nb.info/gnd/4051181-9
classificationCode: 1048495779
subject: Universität Halle (Saale) | Halle (Saale)
valueUri: https://d-nb.info/gnd/1048495779
classificationCode: 2024276-1
subject: Martin-Luther-Universität Halle-Wittenberg | Halle (Saale); Wittenberg
valueUri: https://d-nb.info/gnd/2024276-1
classificationCode: 4020517-4
subject: Geschichte
valueUri: https://d-nb.info/gnd/4020517-4
classificationCode: 7504326-9
subject: Universitätsgeschichte
valueUri: https://d-nb.info/gnd/7504326-9
classificationCode: 7504427-4
subject: Wissenschaftsgeschichte
valueUri: https://d-nb.info/gnd/7504427-4
subject: Biografienportal Sachsen-Anhalt
subject: Catalogus Professorum Halensis
classificationCode: 120134756
subject: Eberle, Henrik | 1970– | Historiker
valueUri: https://d-nb.info/gnd/120134756
classificationCode: 118654918
subject: Behring, Emil von | 1854–1917 | Arzt; Wissenschaftler
valueUri: https://d-nb.info/gnd/118654918

description: Das Biografienportal Sachsen-Anhalt versammelt in Erst- und Zweitveröffentlichung oder zu Zwecken der Langzeitarchivierung Biografien von Menschen aus und in Sachsen-Anhalt. Integriert wurde der Catalogus Professorum Halensis, der durch Mitarbeitende des Instituts für Geschichte der Martin-Luther-Universität Halle-Wittenberg entstand. Dabei handelt es sich um ein bio-bibliografisches Online-Lexikon zu den Professoren der Universität Halle zwischen 1694 und 1968. Die Texte wurden vor allem von Henrik Eberle und anderen Mitarbeitenden zwischen 2005 und 2010 recherchiert und erstellt. Etliche Artikel zum Zeitraum 1694 bis 1817 verfasste Julia Schopferer. Bei der Überführung in das Biografienportal wurden die Lebensangaben neu recherchiert und Metadaten über Verfahren des Named Entity Recogniton erschlossen. Automatisiert erkannt wurden Personennamen, Ortsbezeichnungen und Körperschaften, die in der hier vorhandenen RTF-Datei indexiert vorliegt. Zudem wurden diese mit GND-Einträgen abgeglichen. Weiterhin erfolgte ein Abgleich mit der „Ontologie der historischen, deutschsprachigen Amts- und Berufsbezeichnungen“. Die Texte liegen im Jahr 2024 in zweifacher Ausgabe im Catalogus Professorum Halensis des Universitätsarchivs und des Biografienportals des Historischen Datenzentrums Sachsen-Anhalts vor. Sie werden hier für die Langzeitarchivierung der ursprünglichen Fassung archiviert.
description: https://www.catalogus-professorum-halensis.de/
description: Biografienportal Sachsen-Anhalt: https://www.histdata.uni-halle.de/
title: Model-Based Systems Engineering of the Event-Driven Industrial Internet of Things
Creators: name: Amiri, Amirali
name: Thoma, Max Albin
name: Steindl, Gernot
name: Klaassen, Christoph
name: Kastner, Wolfgang
Publisher: name: TU Wien
Year: 2024
Subjects: Industrial Internet of Things (IIoT)
Model-Based Systems Engineering (MBSE)
Event-Driven Communication

description: The Industrial Internet of Things (IIoT) is characterized by a multitude of standards, protocols, and tools. Moreover, the convergence of Information Technology (IT) and Operational Technology (OT) brings new architectural styles, e.g., event-driven communication, that are easier to scale and integrate IIoT devices. Architects need extensive expertise to manage the complex task of designing systems that encompass hardware, software, information, communication, and users. Proven approaches such as Model-Based Systems Engineering (MBSE) can simplify the design of IIoT systems by offering abstractions through system models and views. In this paper, we introduce an MBSE approach grounded in Systems Modeling Language (SysML) 2.0. Our method involves defining metadata tailored to event-driven IIoT systems. System designers can generate tagged model instances that undergo automatic validation against system requirements, such as asynchronous messaging, authentication, and health checks. Following validation, these models are utilized by an artifact generator to produce code, test cases, or documentation. Our approach is designed for reusability, and we provide tool support to streamline the implementation of requirements checking for emerging standards and guidelines. This enhances the flexibility and efficiency of IIoT system design, ensuring compliance with diverse and evolving industry requirements.
Supplementary document for Dynamics of single cell femtosecond laser printing - 6314126.pdf
Creators: name: Zhang, Jun
name: Frank, Christine
name: Byers, Patrick
name: Djordjevic, Sasa
name: Docheva, Denitsa
name: Clausen-Schaumann, Hauke
name: Sudhop, Stefanie
name: Huber, Heinz
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Fluid Physics

description: Supplemental Document
title: Die Abdominal Pain Unit als Behandlungspfad
title: Strukturierte Versorgung von Patient*innen mit atraumatischen Bauchschmerzen in der Notaufnahme
titleType: Subtitle
Creators: name: Helbig, Lukas
name: Stier, Britta
name: Römer, Claudia
name: Kilian, Maik
name: Slagman, Anna
name: Behrens, Angelika
name: Stiehr, Vera
name: Vollert, Jörn Ole
name: Bachmann, Ulrike
name: Möckel, Martin
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Treatment procedure
subject: Standardization
subject: Acute care
subject: Efficiency
subject: APU
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Patients with atraumatic abdominal pain are common in the emergency department and have a relatively high hospital mortality, with a very wide spectrum of different causes. Rapid, goal-directed diagnosis is essential in this context. Methods: In a Delphi process with representatives of different disciplines, a diagnostic treatment pathway was designed, which is called the Abdominal Pain Unit (APU). Results: The treatment pathway was designed as an extended event process chain. Crucial decision points were specified using standard operating procedures. Discussion: The APU treatment pathway establishes a consistent treatment structure for patients with atraumatic abdominal pain. It has the potential to improve the quality of care and reduce intrahospital mortality over the long term.
title: Wechselwirkung Kläranlage - Gewässer
Creators: name: Kreuzinger, Norbert
name: Franz, Andreas
Publisher: name: TU Wien
Year: 1996
Subjects: Imissionsbetrachtung
Ablaufqualität
Abwasserreinigungsanlage

description: Ausgehend von der Diskussion um zentrale und dezentrale Lösungsansätze für die Abwasserentsorgung im ländlichen Raum soll der Versuch einer Skizzierung der Wechselwirkung zwischen Abwasserreinigungsanlage und Gewässer unternommen werden. Dabei soll unabhängig von einem spezifischen Konzept der Abwasserreinigung ein genereller Rückkoppelungsmechanismus aufgezeigt werden, der von einer Großkläranlage bis hin zur Kleinstkläranlage gleichermaßen gültig ist. Die einzelnen Punkte dieser Wechselwirkung werden besprochen und anhand von Beispielen veranschaulicht. Das System „Abwasserreinigungsanlage“ wird in die Faktoren Planung - realisiertes Projekt, Betrieb, Ablaufqualität und Ablaufquantität unterteilt. Die Untergliederung des Systems „Gewässer“ beschränkt sich auf die für die Bewilligung und Planung relevanten Faktoren Wassermenge, Immission und ökologische Funktionsfähigkeit. Diese Faktoren werden in eine Beziehung zueinander gebracht.
Deep learning for accurately recognizing common causes of shoulder pain on radiographs
Creators: name: Grauhan, Nils F.
name: Niehues, Stefan M.
name: Gaudin, Robert A.
name: Keller, Sarah
name: Vahldiek, Janis L.
name: Adams, Lisa C.
name: Bressem, Keno K.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Convolutional neural network
subject: Deep learning
subject: Orthopedics
subject: Shoulder
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objective: Training a convolutional neural network (CNN) to detect the most common causes of shoulder pain on plain radiographs and to assess its potential value in serving as an assistive device to physicians. Materials and methods: We used a CNN of the ResNet-50 architecture which was trained on 2700 shoulder radiographs from clinical practice of multiple institutions. All radiographs were reviewed and labeled for six findings: proximal humeral fractures, joint dislocation, periarticular calcification, osteoarthritis, osteosynthesis, and joint endoprosthesis. The trained model was then evaluated on a separate test dataset, which was previously annotated by three independent expert radiologists. Both the training and the test datasets included radiographs of highly variable image quality to reflect the clinical situation and to foster robustness of the CNN. Performance of the model was evaluated using receiver operating characteristic (ROC) curves, the thereof derived AUC as well as sensitivity and specificity. Results: The developed CNN demonstrated a high accuracy with an area under the curve (AUC) of 0.871 for detecting fractures, 0.896 for joint dislocation, 0.945 for osteoarthritis, and 0.800 for periarticular calcifications. It also detected osteosynthesis and endoprosthesis with near perfect accuracy (AUC 0.998 and 1.0, respectively). Sensitivity and specificity were 0.75 and 0.86 for fractures, 0.95 and 0.65 for joint dislocation, 0.90 and 0.86 for osteoarthrosis, and 0.60 and 0.89 for calcification. Conclusion: CNNs have the potential to serve as an assistive device by providing clinicians a means to prioritize worklists or providing additional safety in situations of increased workload.
title: Energiemonitoring Käthe-Dorsch-Gasse 17, 1140 Wien
Creators: name: Handler, Simon
name: Enigl, Philipp
name: Herenda, Niklas
Publisher: name: TU Wien
Year: 2024
Subjects: Monitoring
Erdwärme
Erdsonden
Bauteilaktivierung

description: Monitoringergebnisse des mehrgeschoßigen Wohnbaus (ca. 300 Wohnungen). Der Wohnbau ist mit Bauteilaktivierung und einem Sondenfeld als Wärmequelle/Senke ausgestattet. Wärmerückgewinnung aus dem Abwasser für die Warmwasserbereitung.
Novel hybrid coaxial-U-shaped closed-loop geothermal system for enhanced energy extraction: a numerical analysis
Creators: name: Chappidi, Srinivas
name: Kumar, Ankesh
name: Singh, Jogender
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Space Science
Physical Sciences not elsewhere classified
Molecular Biology
Biotechnology
Environmental Sciences not elsewhere classified

description: Insulated U-shaped closed-loop geothermal system (UCLGS) is an efficient and environmentally friendly method of harnessing geothermal energy. However, heat available in the rock surrounding the insulated production pipe has not been extracted yet. Therefore, this study proposed a novel hybrid coaxial-U-shaped CLGS (HCLGS) to enhance the overall thermal performance of CLGS. The HCLGS comprises an insulated UCLGS for harnessing energy from the reservoir rock, alongside a coaxial double pipe system designed to extract additional thermal energy from the rock enveloping the insulated production pipe of the UCLGS. Further, the study explored the thermal feasibility of the proposed HCLGS in various rock formations for geothermal energy extraction at different depths. The results showed that the HCLGS installed in the pyroxenite rock produced primary hot fluid with a maximum temperature of 94°C and secondary hot fluid at a temperature of 38.5°C for the base case, achieving a COP of 1.15. The proposed HCLGS can extract up to 18% higher thermal power than the insulated UCLGS, with a COP ranging from 1.11 to 1.16. Finally, the proposed hybrid system significantly harnessed the additional heat available in the rock encompassing the insulated production pipe of UCLGS.
Preoperative Comparison of Three Anticholinergic Drug Scales in Older Adult Patients and Development of Postoperative Delirium: A Prospective Observational Study
Creators: name: Heinrich, Maria
name: Müller, Anika
name: Cvijan, Andela
name: Mörgeli, Rudolf
name: Kruppa, Jochen
name: Winterer, Georg
name: Slooter, Arjen J. C.
name: Spies, Claudia D.
name: BioCog Consortium
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Postoperative Delirium
subject: Anticholinergic Drug Scales
subject: Older Adult Patients
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Postoperative delirium (POD) is a frequent and serious complication after surgery. Evidence of a relationship between anticholinergic medication and the development of delirium is inconclusive, but studies on POD are rare. Objectives: The objective of this study was to evaluate the anticholinergic load of preoperative medication in older adult patients and its association with the development of POD. Methods: This investigation was part of the European BioCog project (http://www.bioco g.eu), a prospective multicenter observational study in older adult surgical patients (ClinicalTrials.gov identifier: NCT02265263, 15 October 2014). Patients with a Mini-Mental State Examination score <= 23 points were excluded. POD was assessed up to 7 days after surgery using the Nursing Delirium Screening Scale, Confusion Assessment Method and a patient chart review. The preoperative anticholinergic load was calculated using the Anticholinergic Drug Scale (ADS), the Anticholinergic Risk Scale (ARS) and the Anticholinergic Cognitive Burden Scale (ACBS), and associations with POD were analyzed using logistic regression analysis adjusting for age, comorbidities, duration of anesthesia and number of drugs used. Results: In total, 837 participants were included for analysis, and 165 patients (19.7%) fulfilled the criteria of POD. After adjusting for confounders, we found no association between preoperative anticholinergic load and the development of POD (ADS [points] odds ratio [OR] 0.928; 95% confidence interval [CI] 0.749-1.150; ARS [points] OR 0.832; 95% CI 0.564-1.227; ACBS [points] OR 1.045; 95% CI 0.842-1.296). Conclusion: This study found no association between the anticholinergic load of drugs used preoperatively and the development of POD in older adult patients without severe preexisting cognitive impairment. Future analyses should examine the influence of intra- and postoperative administration of anticholinergic drugs as well as dosages of and interactions between medications.
Single-cell RNA sequencing reveals distinct tumor microenvironmental patterns in lung adenocarcinoma
Creators: name: Bischoff, Philip
name: Trinks, Alexandra
name: Obermayer, Benedikt
name: Pett, Jan Patrick
name: Wiederspahn, Jennifer
name: Uhlitz, Florian
name: Liang, Xizi
name: Lehmann, Annika
name: Jurmeister, Philipp
name: Elsner, Aron
name: Dziodzio, Tomasz
name: Rückert, Jens-Carsten
name: Neudecker, Jens
name: Falk, Christine
name: Beule, Dieter
name: Sers, Christine
name: Morkel, Markus
name: Horst, David
name: Blüthgen, Nils
name: Klauschen, Frederick
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Single-cell RNA sequencing
subject: lung adenocarcinoma
subject: tumor microenvironmental patterns
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Recent developments in immuno-oncology demonstrate that not only cancer cells, but also the tumor microenvironment can guide precision medicine. A comprehensive and in-depth characterization of the tumor microenvironment is challenging since its cell populations are diverse and can be important even if scarce. To identify clinically relevant microenvironmental and cancer features, we applied single-cell RNA sequencing to ten human lung adenocarcinomas and ten normal control tissues. Our analyses revealed heterogeneous carcinoma cell transcriptomes reflecting histological grade and oncogenic pathway activities, and two distinct microenvironmental patterns. The immune-activated (CPE)-E-2 microenvironment was composed of cancer-associated myofibroblasts, proinflammatory monocyte-derived macrophages, plasmacytoid dendritic cells and exhausted CD8+ T cells, and was prognostically unfavorable. In contrast, the inert (NMC)-M-3 microenvironment was characterized by normal-like myofibroblasts, non-inflammatory monocyte-derived macrophages, NK cells, myeloid dendritic cells and conventional T cells, and was associated with a favorable prognosis. Microenvironmental marker genes and signatures identified in single-cell profiles had progonostic value in bulk tumor profiles. In summary, single-cell RNA profiling of lung adenocarcinoma provides additional prognostic information based on the microenvironment, and may help to predict therapy response and to reveal possible target cell populations for future therapeutic approaches.
Frequency of silent brain infarction in transient global amnesia
Creators: name: Ganeshan, Ramanan
name: Betz, Manja
name: Scheitz, Jan F.
name: Erdur, Hebun
name: Audebert, Heinrich J.
name: Fiebach, Jochen B.
name: Villringer, Kersten
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Transient global amnesia
subject: MRI
subject: Autonomic nervous system
subject: Brain-heart syndrome
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: and purpose To determine the frequency and distribution pattern of acute DWI lesions outside the hippocampus in patients clinically presenting with Transient Global Amnesia (TGA). Methods: Consecutive patients clinically presenting with TGA between January 2010 and January 2017 admitted to our hospital were retrospectively evaluated. All patients fulfilled diagnostic criteria of TGA. We analyzed imaging and clinical data of all patients undergoing MRI with high-resolution diffusion-weighted imaging within 72 h from symptom onset. Results: A total of 126 cases were included into the study. Fifty-three percent (n = 71/126) presented with one or more acute lesions in hippocampal CA1-area. Additional acute DWI lesions in other cortical regions were found in 11% (n = 14/126). All patients with DWI lesions outside the hippocampus presented with neurological symptoms typical for TGA (without additional symptoms.) Conclusions: In a relevant proportion of clinical TGA patients, MRI reveals acute ischemic cerebral lesions. Therefore, cerebral MRI should be performed in patients with TGA to identify a possible cardiac involvement and to detect stroke chameleons.
Supplementary document for Picosecond x-ray magnetic circular dichroism spectroscopy at the Fe L-edges with a laser-driven plasma source - 6314458.pdf
Creators: name: Schick, Daniel
name: Borchert, Martin
name: Engel, Wolfgang-Dietrich
name: von Korff Schmising, Clemens
name: Pfau, Bastian
name: Eisebitt, Stefan
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental Material
Factors influencing the presence of Candida dubliniensis and other non-albicans species in patients with oral lichen planus: a retrospective observational study
Creators: name: Molkenthin, Florian
name: Hertel, Moritz
name: Neumann, Konrad
name: Schmidt-Westhausen, Andrea Maria
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Candida
subject: Oral lichen planus
subject: Non-albicans species
subject: Oral candidiasis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objectives: The epidemiologic distribution of non-albicans species in the oral cavity of oral lichen planus (OLP) patients remains uncertain. Therefore, the aim of this study was to identify factors associated with the presence of C. dubliniensis and other non-albicans species. Furthermore, independent risk factors for Candida superinfection in OLP should be identified. Material and methods: Epidemiologic data and microbiological findings from 268 symptomatic OLP patients who underwent continuous oral swab culture over a 5-year period (2015-2019) were retrospectively reviewed. Candida species identification and semi-quantification were obtained by culture on CHROMagar Candida, followed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Results: C. albicans was the most frequently isolated species (72.3%), followed by C. glabrata (7.3%), C. dubliniensis (5.8%), C. krusei and C. parapsilosis (both 2.6%). The presence of C. dubliniensis was significantly associated with tobacco smoking. Other non-albicans spp. were significantly more often detected in patients using removable dentures. Increasing age and the intake of psychotropic drugs were identified as independent risk factors of Candida superinfection in OLP. Conclusion: In OLP patients, certain local and systemic factors increase the risk of carrying potentially drug-resistant Candida species and the development of Candida superinfection of OLP lesions. Clinical relevance: Due to the frequent detection of non-albicans species in OLP, resistance or at least reduced sensitivity to azole antifungals should be expected, especially in smokers and patients using removable dentures. In the case of oral complaints, a superinfection with Candida should be considered, whereby older patients and patients taking psychotropic drugs have an increased risk for oral infection with Candida.
Novel Treatment Approaches for Substance Use Disorders: Therapeutic Use of Psychedelics and the Role of Psychotherapy
Creators: name: Koslowski, Michael
name: Johnson, Matthew W.
name: Gründer, Gerhard
name: Betzler, Felix
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Psychedelics
subject: LSD
subject: Psilocybin
subject: Psychotherapy
subject: Psychodynamic
subject: CBT
subject: Addiction
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose of Review: The use of psychedelics in a therapeutical setting has been reported for the treatment of various diagnoses in recent years. However, as psychedelic substances are still commonly known for their ( illicit) recreational use, it may seem counterintuitive to use psychedelic therapy to treat substance use disorders. This review aims to discuss how psychedelics can promote and intensify psychotherapeutic key processes, in different approaches like psychodynamic and cognitive behavioral therapy, with a spotlight on the treatment of substance use disorders (SUD). Recent Findings: There is promising evidence of feasibility, safety, and efficacy of psychedelic therapy in SUD. In the whole process of former and current psychedelic therapy regimes that have shown to be safe and efficacious, various psychotherapeutic elements, both psychodynamic and behavioral as well as other approaches, can be identified, while a substantial part of the assumed mechanism of action, the individual psychedelic experience, cannot be distinctly classified to just one approach. Summary: Psychedelic therapy consists of a complex interaction of pharmacological and psychological processes. When administered in well-defined conditions, psychedelics can serve as augmentation of different psychotherapy interventions in the treatment of SUD and other mental disorders, regardless of their theoretical origin.
Virtual Reality-Based Treatment Approaches in the Field of Substance Use Disorders
Creators: name: Tsamitros, Nikolaos
name: Sebold, M.
name: Gutwinski, Stefan
name: Beck, A.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Virtual reality
subject: Addiction
subject: Craving
subject: Cue reactivity
subject: Relapse
subject: Cue exposure therapy
subject: Substance use disorders
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: Substance use disorders (SUD) are burdening chronic conditions characterized by high relapse rates despite severe negative consequences. Substance-related cues that elicit craving by means of automatic physiological and behavioural responses have long been suggested to predict relapse. One major mechanism contributing to relapse behaviour are cue-induced behavioural approach tendencies towards the addictive agent. Recently, there has been an emerging interest in virtual reality (VR)-based approaches to assess and modify craving and its related responses. This review aims at elucidating (1) VR techniques applied in the field of SUD, (2) VR as an induction/assessment tool for biopsychological correlates of craving and (3) VR-based therapeutic approaches. Findings: There is an emerging number of studies focusing on different substances of abuse incorporating VR in craving induction/assessment as well as therapy. Despite some limitations as missing of randomized controlled clinical trials with large samples and missing data on the long-term effects of VR treatment, the VR approach showed consistent results in eliciting and reducing craving across different substances. Summary: This review suggests virtual reality as a promising tool for the assessment and treatment of craving among individuals with substance use disorders. Because of its ecological validity, VR unifies the benefits of a laboratory setting with the advantages of a realistic environment. Further studies with large samples and randomized controlled clinical trials using more homogenous VR techniques as well as assessment of objective biophysiological craving markers are required.
Einsatz von Instrumenten bei der klinischen Untersuchung in deutschen HNO-Abteilungen und Privatpraxen heutzutage
Creators: name: Franzen, Achim M.
name: Sykora, Hannes
name: Hauptmann, Michael
name: Coordes, Annekatrin
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Otorhinolaryngology
subject: Forehead mirror
subject: Microscope
subject: Endoscope
subject: Otoscope
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: The classical forehead reflector as traditionally used by ear, nose, and throat (ENT) physicians for the ENT examination is now iconic for doctors in general. It is unknown which instruments are currently used in Germany to clinically examine ENT patients. Therefore, this study aims to present results of a survey about commonly used instruments. Materials and methods: An evaluation of 321 questionnaires from ENT doctors working in general and university hospitals (172) and in private practices (149) was performed. Results: The ENT mirror examination is nowadays carried out with a self-illuminating headlamp with battery and/or light guide cable. Approximately 20% of respondents also use a forehead mirror. The microscope is used by 90% of doctors to examine the ears; a rigid endoscope was used in 53.3% to examine the larynx, epipharynx (41.1%), and the nose/sinuses (34.6%). Flexible endoscopes and otoscopes are used only rarely. Conclusion: The self-illuminating headlamp, which is more often wireless in eastern Germany, has largely replaced the classical forehead reflector, with which doctors younger than 40 years were no longer trained. At least some organs are also examined very regularly with the microscope or rigid endoscope. The flexible endoscope and otoscope are used much less frequently overall, mainly by younger physicians and ENT doctors working in hospitals. The diagnostic potential of flexible endoscopy may be compromised by the outpatient remuneration structures in Germany.
Mindfulness in Treatment Approaches for Addiction — Underlying Mechanisms and Future Directions
Creators: name: Rosenthal, Annika
name: Levin, Michael E.
name: Garland, Eric L.
name: Romanczuk-Seiferth, Nina
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Mindfulness
subject: Addiction
subject: Mechanisms
subject: Intervention
subject: Reward
subject: Stress
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose of Review: While the treatment of addictive disorders proves to be challenging, new treatment approaches that evolved around the concepts of mindfulness and acceptance have been utilized and investigated in recent years. Our goal is to summarize the efficacy and possible underlying mechanisms of mindfulness-based interventions (MBI) in addictive disorders. Recent Findings: Various meta-analyses have suggested that MBIs show clinical efficacy in the treatment of addictive disorders. Considering the factors that impact addictive disorders, MBIs have been indicated to augment responsiveness to natural rewards in contrast to addiction-related cues as well as to increase top-down cognitive control, decrease subjective and physiological stress perception, and enhance positive affect. Summary: In summary, MBIs hold promise in treating addictive disorders while larger randomized controlled trials with longitudinal study designs are needed to confirm their utility. Newest clinical endeavors strive to enhance the clinical utility of MBIs by augmentation or personalization.
title: Effects of introducing the DRG system on medical treatments in a neurological department
title: Auswirkungen des DRG-Systems auf die Behandlung in einer Neurologischen Akutklinik
Creators: name: Poerschke, Yvonne
Publisher: name: Philipps-Universität Marburg
Year: 2016
Subjects: DRG-System
Neurologische Fallpauschalen
Diagnosis-related-groups-Konzept
Medical sciences, Medicine
Medizin, Gesundheit
Tagesgleiche Pflegesätze

description: The present study analyses the
      effects of introducing the DRG system using the example of
      the Neurologische Klinik Bad Zwesten, a relatively
      homogeneous 40 beds department within a neurological centre
      including all stages of neurological treatment. For that
      purpose, collectives of patients before and after the
      implementation of the DRG systems were evaluated. In hospital
      treated patients of the Neurologische Akutklinik of each
      half-year 1996 (n=463) and 2008 (n=910) were compared. The
      main results could be found in the alterations concerning
      main diagnosis, length of stay and in a hypothetical
      comparison of the reimbursement of hospital
      treatments.
description: In der vorliegenden Arbeit werden
      die Auswirkungen der Etablierung des DRG-Systems am Beispiel
      der Neurologischen Akutklinik Bad Zwesten, einer homogenen
      40-Betten-Abteilung innerhalb eines Neurologischen Zentrums
      mit allen Phasen der neurologischen Behandlung, untersucht.
      Dazu werden Patientenkollektive vor und nach Einführung des
      DRG-Systems herangezogen. Verglichen werden die stationär
      behandelten Patienten der NAK des jeweils ersten Halbjahres
      1996 (n = 463) und 2008 (n = 910). Als wesentliche Ergebnisse
      sind die Veränderungen bezüglich häufigster Hauptdiagnosen,
      Verweildauer und, in einem hypothetischen Vergleich, der
      Behandlungserlöse zu sehen.
Prediction of prostate cancer grade using fractal analysis of perfusion MRI: retrospective proof-of-principle study
Creators: name: Michallek, Florian
name: Huisman, Henkjan
name: Hamm, Bernd
name: Elezkurtaj, Sefer
name: Maxeiner, Andreas
name: Dewey, Marc
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Prostatic neoplasms
subject: Neoplasm grading
subject: Perfusion
subject: Fractals
subject: Multiparametric magnetic resonance imaging
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objectives: Multiparametric MRI has high diagnostic accuracy for detecting prostate cancer, but non-invasive prediction of tumor grade remains challenging. Characterizing tumor perfusion by exploiting the fractal nature of vascular anatomy might elucidate the aggressive potential of a tumor. This study introduces the concept of fractal analysis for characterizing prostate cancer perfusion and reports about its usefulness for non-invasive prediction of tumor grade. Methods: We retrospectively analyzed the openly available PROSTATEx dataset with 112 cancer foci in 99 patients. In all patients, histological grading groups specified by the International Society of Urological Pathology (ISUP) were obtained from in-bore MRI-guided biopsy. Fractal analysis of dynamic contrast-enhanced perfusion MRI sequences was performed, yielding fractal dimension (FD) as quantitative descriptor. Two-class and multiclass diagnostic accuracy was analyzed using area under the curve (AUC) receiver operating characteristic analysis, and optimal FD cutoffs were established. Additionally, we compared fractal analysis to conventional apparent diffusion coefficient (ADC) measurements. Results: Fractal analysis of perfusion allowed accurate differentiation of non-significant (group 1) and clinically significant (groups 2-5) cancer with a sensitivity of 91% (confidence interval [CI]: 83-96%) and a specificity of 86% (CI: 73-94%). FD correlated linearly with ISUP groups (r(2) =0.874, p < 0.001). Significant groupwise differences were obtained between low, intermediate, and high ISUP group 1-4 (p <= 0.001) but not group 5 tumors. Fractal analysis of perfusion was significantly more reliable than ADC in predicting non-significant and clinically significant cancer (AUC(FD) =0.97 versus AUC(ADC) = 0.77, p < 0.001). Conclusion: Fractal analysis of perfusion MRI accurately predicts prostate cancer grading in low-, intermediate-, and high-, but not highest-grade, tumors.
Brains in space: the importance of understanding the impact of long-duration spaceflight on spatial cognition and its neural circuitry
Creators: name: Stahn, Alexander C.
name: Kühn, Simone
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Spatial cognition
subject: Hippocampus
subject: Spaceflight
subject: Extreme environments
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Fifty years after the first humans stepped on the Moon, space faring nations have entered a new era of space exploration. NASA's reference mission to Mars is expected to comprise 1100 days. Deep space exploratory class missions could even span decades. They will be the most challenging and dangerous expeditions in the history of human spaceflight and will expose crew members to unprecedented health and performance risks. The development of adverse cognitive or behavioral conditions and psychiatric disorders during those missions is considered a critical and unmitigated risk factor. Here, we argue that spatial cognition, i.e., the ability to encode representations about self-to-object relations and integrate this information into a spatial map of the environment, and their neural bases will be highly vulnerable during those expeditions. Empirical evidence from animal studies shows that social isolation, immobilization, and altered gravity can have profound effects on brain plasticity associated with spatial navigation. We provide examples from historic spaceflight missions, spaceflight analogs, and extreme environments suggesting that spatial cognition and its neural circuitry could be impaired during long-duration spaceflight, and identify recommendations and future steps to mitigate these risks.
Time pressure predicts decisional regret in men with localized prostate cancer: data from a longitudinal multicenter study
Creators: name: Hilger, Caren
name: Schostak, Martin
name: Otto, Isabella
name: Kendel, Friederike
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Decisional regret
subject: Erectile functioning
subject: Localized prostate cancer
subject: Satisfaction with sexual life
subject: Time pressure
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: A substantial proportion of men with localized prostate cancer (lPCa) later regret their treatment decision. We aimed to identify factors contributing to decisional regret. Methods: We conducted a longitudinal study, in which men with lPCa were surveyed at four measurement points: T0 (baseline) = prior to treatment; T1 = 6; T2 = 12; T3 = 18 months after baseline. chi(2)-tests and independent t-tests were used to compare men undergoing different treatments [Active Surveillance (AS) vs. local treatment]. Logistic regression models were fitted to investigate the associations between predictors (time pressure, information provided by the urologist, impairment of erectile functioning, satisfaction with sexual life) and the criterion decisional regret. Results: At baseline, the sample included N = 176 men (AS: n = 100; local treatment: n = 76). At T2 and T3, men after local therapies reported higher regret than men under AS. Decisional regret at T3 was predicted by time pressure at baseline (OR 2.28; CI 1.04-4.99; p < 0.05), erectile dysfunction at T2 and T3 (OR 3.40; CI 1.56-7.42; p < 0.01), and satisfaction with sexual life at T1-T3 (OR 0.44; CI 0.20-0.96; p < 0.05). Conclusions: Time pressure, erectile dysfunction, and satisfaction with sexual life predict decisional regret in men with lPCa. Mitigating time pressure and realistic expectations concerning treatment side effects may help to prevent decisional regret in PCa survivors.
Deep learning for cephalometric landmark detection: systematic review and meta-analysis
Creators: name: Schwendicke, Falk
name: Chaurasia, Akhilanand
name: Arsiwala, Lubaina
name: Lee, Jae-Hong
name: Elhennawy, Karim
name: Jost-Brinkmann, Paul-Georg
name: Demarco, Flavio
name: Krois, Joachim
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Artificial intelligence
subject: Convolutional neural networks
subject: Evidence-based medicine
subject: Meta-analysis
subject: Orthodontics
subject: Systematic review
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objectives: Deep learning (DL) has been increasingly employed for automated landmark detection, e.g., for cephalometric purposes. We performed a systematic review and meta-analysis to assess the accuracy and underlying evidence for DL for cephalometric landmark detection on 2-D and 3-D radiographs. Methods: Diagnostic accuracy studies published in 2015-2020 in Medline/Embase/IEEE/arXiv and employing DL for cephalometric landmark detection were identified and extracted by two independent reviewers. Random-effects meta-analysis, subgroup, and meta-regression were performed, and study quality was assessed using QUADAS-2. The review was registered (PROSPERO no. 227498). Data: From 321 identified records, 19 studies (published 2017-2020), all employing convolutional neural networks, mainly on 2-D lateral radiographs (n=15), using data from publicly available datasets (n=12) and testing the detection of a mean of 30 (SD: 25; range.: 7-93) landmarks, were included. The reference test was established by two experts (n=11), 1 expert (n=4), 3 experts (n=3), and a set of annotators (n=1). Risk of bias was high, and applicability concerns were detected for most studies, mainly regarding the data selection and reference test conduct. Landmark prediction error centered around a 2-mm error threshold (mean; 95% confidence interval: (-0.581; 95 CI: -1.264 to 0.102 mm)). The proportion of landmarks detected within this 2-mm threshold was 0.799 (0.770 to 0.824). Conclusions: DL shows relatively high accuracy for detecting landmarks on cephalometric imagery. The overall body of evidence is consistent but suffers from high risk of bias. Demonstrating robustness and generalizability of DL for landmark detection is needed. Clinical significance: Existing DL models show consistent and largely high accuracy for automated detection of cephalometric landmarks. The majority of studies so far focused on 2-D imagery; data on 3-D imagery are sparse, but promising. Future studies should focus on demonstrating generalizability, robustness, and clinical usefulness of DL for this objective.
Project Identity: Brand, Marketing Basics and Website
Creators: name: DEL VALLE-ZERMEÑO, RICARDO
name: Haferburg, Katja
Publisher: name: Zenodo
Year: 2024

description: The deliverable D6.1 Marketing basics is part of Work Package 6- Communication and Dissemination which aims to increase awareness of the ZEvRA EU project by means of a coherent visual identity and by identifying audiences for disseminating successes and results and communicating project developments and news.  This document explains and shows the visual identity of ZEvRA including a colour palette and logos as well as fonts and templates. Three marketing materials for print were developed and are available on the website: a flyer, a brochure and a banner. A project website has been set up at www.zevraproject.eu and is presented in chapter 4.
title: Balloonsinuplasty as a therapy in chronic rhinosinusitis - a retrospective analysis among patients of the Marburg universitary ENT hospital
title: Die Ballonsinuplastik als Behandlungsform rezidivierender Sinusitiden - Eine retrospektive Analyse am Patientengut der Marburger Universität-HNO-Klinik
Creators: name: Jendryan, Annika
Publisher: name: Philipps-Universität Marburg
Year: 2016
Subjects: Nasennebenhöhlen
Medical sciences, Medicine
Medizin, Gesundheit
Chronic Rhinosinusitis
Balloon Dilation
Paranasal Sinus
SNOT 20, Lund-Mackay
Ostium
Chronische Rhinosinusitis
Ballon
Dilatation

description: Auswertung des Behandlungserfolgs
      der Ballonsinuplastik an 31 Patienten in einem Zeitraum von
      einem Jahr an der Universitätklinik Marburg. Verwendung der
      Scores SNOT 20 und Lund-Mackay, sowie Untersuchung der
      Durchleuchtungszeit und der Ostienweite der behandelten
      Nasennebenhöhlenostien.
description: Evaluation of surgical succuess of
      balloon sinuplasty including 31 patients during one year at
      the universitary hospital Marburg. Use of validated scores
      SNOT 20 and Lund-Mackay, as well as evaluation of duration of
      fluoroscopy and with of ostia that have been treated.