cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Characterizing and Subsetting Big Data Workloads
Creators: name: Jia, Zhen
name: Zhan, Jianfeng
name: Wang, Lei
name: Han, Rui
name: McKee, Sally A.
name: Yang, Qiang
name: Luo, Chunjie
name: Li, Jingwei
Publisher: name: arXiv
Year: 2014
Subjects: subject: Performance (cs.PF)
subject: FOS: Computer and information sciences

description: Big data benchmark suites must include a diversity of data and workloads to be useful in fairly evaluating big data systems and architectures. However, using truly comprehensive benchmarks poses great challenges for the architecture community. First, we need to thoroughly understand the behaviors of a variety of workloads. Second, our usual simulation-based research methods become prohibitively expensive for big data. As big data is an emerging field, more and more software stacks are being proposed to facilitate the development of big data applications, which aggravates hese challenges. In this paper, we first use Principle Component Analysis (PCA) to identify the most important characteristics from 45 metrics to characterize big data workloads from BigDataBench, a comprehensive big data benchmark suite. Second, we apply a clustering technique to the principle components obtained from the PCA to investigate the similarity among big data workloads, and we verify the importance of including different software stacks for big data benchmarking. Third, we select seven representative big data workloads by removing redundant ones and release the BigDataBench simulation version, which is publicly available from http://prof.ict.ac.cn/BigDataBench/simulatorversion/.
description: 11 pages, 6 figures, 2014 IEEE International Symposium on Workload Characterization
Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway
Creators: name: Amuchastegui, Carmen S.
name: Nataraj, Chandra
name: Mannon, Roslyn B.
name: Coffman, Thomas M.
name: Audoly, Laurent P.
name: Ruiz, Phillip
name: Oliverio, Michael I.
name: Smithies, Oliver
name: Mannon, Peter J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: The renin-angiotensin system (RAS) is a key regulator of vascular tone and blood pressure. In addition, angiotensin II also has a number of cellular effects that may contribute to disease pathogenesis. Using Agtr1a–/– mice, which lack AT1A receptors for angiotensin II, we have identified a novel function of the RAS to modulate the immune system. We find that angiotensin II, acting through type 1 (AT1) receptors on immune cells, triggers the proliferation of splenic lymphocytes. These actions contribute to the vigor of cellular alloimmune responses. Within lymphoid organs, sufficient components of the RAS are present to activate AT1 receptors during an immune response, promoting cell growth. These actions require activation of calcineurin phosphatase. In an in vivo model of cardiac transplantation, the absence of AT1 signaling accentuates the immunosuppressive effects of the calcineurin inhibitor cyclosporine. We conclude that inhibition of AT1 receptor signaling should be useful as an anti-inflammatory and immunosuppressive therapy. Furthermore, the actions of the RAS to promote lymphocyte activation may contribute to inflammation that characterizes a number of diseases of the heart and the vascular system.
Perturbed precessing ellipses as the building blocks of spiral arms in a barred galaxy with two pattern speeds
Creators: name: Harsoula, M.
name: Efthymiopoulos, C.
name: Contopoulos, G.
name: Tzemos, A. C.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Observations and simulations of barred spiral galaxies have shown that, in general, the spiral arms rotate at a different pattern speed to that of the bar. The main conclusion from the bibliography is that the bar rotates faster than the spiral arms with a double or even a triple value of angular velocity. The theory that prevails in explaining the formation of the spiral arms in the case of a barred spiral galaxy with two pattern speeds is the manifold theory, where the orbits that support the spiral density wave are chaotic, and are related to the manifolds emanating from the Lagrangian points L_1 and L_2 at the end of the bar. In the present study, we consider an alternative scenario in the case where the bar rotates fast enough in comparison with the spiral arms and the bar potential can be considered as a perturbation of the spiral potential. In this case, the stable elliptical orbits that support the spiral density wave (in the case of grand design galaxies) are transformed into quasiperiodic orbits (or 2D tori) with a certain thickness. The superposition of these perturbed preccesing ellipses for all the energy levels of the Hamiltonian creates a slightly perturbed symmetrical spiral density wave.
description: 9 pages, 7 figures
Orbital stability of smooth solitary waves for the $b$-family of Camassa-Holm equations
Creators: name: Long, Teng
name: Liu, Changjian
Publisher: name: arXiv
Year: 2022
Subjects: subject: Analysis of PDEs (math.AP)
subject: Classical Analysis and ODEs (math.CA)
subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 35Q35, 37G15, 37K40

description: In this paper, we study the stability of smooth solitary waves for the $b$-family of Camassa-Holm equations. We verify the stability criterion analytically for the general case $b>1$ by the idea of the monotonicity of the period function for planar Hamiltonian systems and show that the smooth solitary waves are orbitally stable, which gives a positive answer to the open problem proposed by Lafortune and Pelinovsky [S. Lafortune, D. E. Pelinovsky, Stability of smooth solitary waves in the $b$-Camassa-Holm equation].
Is Sensory Integration & Praxis Test Useful in  India? Single Parameter Index Analysis in an  Indian Set Up
Creators: name: Anjan Bhattacharya
name: Jewel Chakraborty
Publisher: name: IJDBP
Year: 2023
Subjects: Sensory Integration; Sensory Processing; Sensory Dysfunction; Special Needs; Learning Problems; Neurodevelopmental Disorders; Child Development Centre

description: Introduction:  Integration  of  various  senses  is   a  function  of  childhood  development.  Subtle  
problems  in  these  areas  of  development  leads  to  many  problems  in  children  and  adult  life  
including   learning   and   emotional   problems.  Currently,  these  can  be  measured  reliably  and  
thus, remedied; leading to satisfactory resolution,  if intervened early. Sensory Integration & Praxis  Test (SIPT) is one such tool.
Apo E structure determines VLDL clearance and atherosclerosis risk in mice
Creators: name: Sullivan, Patrick M.
name: Knouff, Christopher
name: Maeda, Nobuyo
name: Hinsdale, Myron E.
name: Altenburg, Michael K.
name: Quarfordt, Steven H.
name: Mezdour, Hafid
name: Watanabe, Masahiko
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: We have generated mice expressing the human apo E4 isoform in place of the endogenous murine apo E protein and have compared them with mice expressing the human apo E3 isoform. Plasma lipid and apolipoprotein levels in the mice expressing only the apo E4 isoform (4/4) did not differ significantly from those in mice with the apo E3 isoform (3/3) on chow and were equally elevated in response to increased lipid and cholesterol in their diet. However, on all diets tested, the 4/4 mice had approximately twice the amount of cholesterol, apo E, and apo B-48 in their VLDL as did 3/3 mice. The 4/4 VLDL competed with human LDL for binding to the human LDL receptor slightly better than 3/3 VLDL, but the VLDL clearance rate in 4/4 mice was half that in 3/3 mice. On an atherogenic diet, there was a trend toward greater atherosclerotic plaque size in 4/4 mice compared with 3/3 mice. These data, together with our earlier observations in wild-type and human APOE*2-replacement mice, demonstrate a direct and highly significant correlation between VLDL clearance rate and mean atherosclerotic plaque size. Therefore, differences solely in apo E protein structure are sufficient to cause alterations in VLDL residence time and atherosclerosis risk in mice.
Gwadaptive_scattering: an automated pipeline for scattered light noise characterization
Creators: name: Bianchi, Stefano
name: Longo, Alessandro
name: Valdes, Guillermo
name: González, Gabriela
name: Plastino, Wolfango
Publisher: name: arXiv
Year: 2021
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences

description: Scattered light noise affects the sensitivity of gravitational waves detectors. The characterization of such noise is needed to mitigate it. The time-varying filter empirical mode decomposition algorithm is suitable for identifying signals with time-dependent frequency such as scattered light noise (or scattering). We present a fully automated pipeline based on the pytvfemd library, a python implementation of the tvf-EMD algorithm, to identify objects inducing scattering in the gravitational-wave channel with their motion. The pipeline application to LIGO Livingston O3 data shows that most scattering noise is due to the penultimate mass at the end of the X-arm of the detector (EXPUM) and with a motion in the micro-seismic frequency range.
description: 14 pages, 8 figures
Near-field radiative heat transfer between closely spaced graphene and amorphous SiO$_2$
Creators: name: Volokitin, A. I.
name: Persson, B. N. J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study the near-field radiative energy transfer between graphene and an amorphous SiO$_2$ substrate. In comparison with the existing theories of near-field radiative heat transfer our theory takes into account that the free carriers in graphene are moving relative to the substrate with a drift velocity $v$. In this case the heat flux is determined by both thermal and quantum fluctuations. We find that quantum fluctuations give an important contribution to the radiative energy transfer for low temperatures and high electric field (large drift velocities). For nonsuspended graphene the near-field radiative energy transfer gives a significant contribution to the heat transfer, in addition to the contribution from phononic coupling. For suspended graphene (large separation) the corresponding radiative energy transfer coefficient at nanoscale gap is $\sim$ 3 orders of magnitude larger than radiative heat transfer coefficient of the blackbody radiation limit.
description: 4 pages, 2 figures. arXiv admin note: text overlap with arXiv:1112.4912, arXiv:1012.5212, arXiv:1409.0145
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 6 (38)]
Creators: name: Johannes
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1415
Subjects: subject: Sonstige geistliche Aussteller
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Johannes de Cigognariis, praepositus des Klosters St. Cataldi in Cremona, verpachtet dem Christoforus de Serasiis, Sohn des verstorbenen Zilotus, aus der Nachbarschaft St. Apollinarii in Cremona ein Stück Land, gelegen im Stadtgebiet Cremonas.
A Random Batch Method for Efficient Ensemble Forecasts of Multiscale Turbulent Systems
Creators: name: Qi, Di
name: Liu, Jian-Guo
Publisher: name: arXiv
Year: 2022
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: A new efficient ensemble prediction strategy is developed for a general turbulent model framework with emphasis on the nonlinear interactions between large and small scale variables. The high computational cost in running large ensemble simulations of high dimensional equations is effectively avoided by adopting a random batch decomposition of the wide spectrum of the fluctuation states which is a characteristic feature of the multiscale turbulent systems. The time update of each ensemble sample is then only subject to a small portion of the small-scale fluctuation modes in one batch, while the true model dynamics with multiscale coupling is respected by frequent random resampling of the batches at each time updating step. We investigate both theoretical and numerical properties of the proposed method. First, the convergence of statistical errors in the random batch model approximation is shown rigorously independent of the sample size and full dimension of the system. Then, the forecast skill of the computational algorithm is tested on two representative models of turbulent flows exhibiting many key statistical phenomena with direct link to realistic turbulent systems. The random batch method displays robust performance in capturing a series of crucial statistical features of general interests including highly non-Gaussian fat-tailed probability distributions and intermittent bursts of instability, while requires a much lower computational cost than the direct ensemble approach. The efficient random batch method also facilitates the development of new strategies in uncertainty quantification and data assimilation for a wide variety of complex turbulent systems in science and engineering.
description: 23 pages, 6 figures
OSLO: On-the-Sphere Learning for Omnidirectional images and its application to 360-degree image compression
Creators: name: Bidgoli, Navid Mahmoudian
name: Azevedo, Roberto G. de A.
name: Maugey, Thomas
name: Roumy, Aline
name: Frossard, Pascal
Publisher: name: arXiv
Year: 2021
Subjects: subject: Image and Video Processing (eess.IV)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: State-of-the-art 2D image compression schemes rely on the power of convolutional neural networks (CNNs). Although CNNs offer promising perspectives for 2D image compression, extending such models to omnidirectional images is not straightforward. First, omnidirectional images have specific spatial and statistical properties that can not be fully captured by current CNN models. Second, basic mathematical operations composing a CNN architecture, e.g., translation and sampling, are not well-defined on the sphere. In this paper, we study the learning of representation models for omnidirectional images and propose to use the properties of HEALPix uniform sampling of the sphere to redefine the mathematical tools used in deep learning models for omnidirectional images. In particular, we: i) propose the definition of a new convolution operation on the sphere that keeps the high expressiveness and the low complexity of a classical 2D convolution; ii) adapt standard CNN techniques such as stride, iterative aggregation, and pixel shuffling to the spherical domain; and then iii) apply our new framework to the task of omnidirectional image compression. Our experiments show that our proposed on-the-sphere solution leads to a better compression gain that can save 13.7% of the bit rate compared to similar learned models applied to equirectangular images. Also, compared to learning models based on graph convolutional networks, our solution supports more expressive filters that can preserve high frequencies and provide a better perceptual quality of the compressed images. Such results demonstrate the efficiency of the proposed framework, which opens new research venues for other omnidirectional vision tasks to be effectively implemented on the sphere manifold.
description: Accepted for publication in IEEE Transactions on Image Processing
Leukocyte infection by the granulocytic ehrlichiosis agent is linked to expression of a selectin ligand
Creators: name: Klein, Marina B.
name: Nelson, Curtis M.
name: Goodman, Jesse L.
name: Hayes, Stanley F.
name: Weston, Brent W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: Human granulocytic ehrlichiosis (HGE) is an emerging tickborne illness caused by an intracellular bacterium that infects neutrophils. Cells susceptible to HGE express sialylated Lewis x (CD15s), a ligand for cell selectins. We demonstrate that adhesion of HGE to both HL60 cells and normal bone marrow cells directly correlates with their CD15s expression. HGE infection of HL60 cells, bone marrow progenitors, granulocytes, and monocytes was blocked by monoclonal antibodies against CD15s. However, these antibodies did not inhibit HGE binding, and anti-CD15s was capable of inhibiting the growth of HGE after its entry into the target cell. In contrast, neuraminidase treatment of HL60 cells prevented both HGE binding and infection. A cloned cell line (HL60-A2), derived from HL60 cells and resistant to HGE, was deficient in the expression of α-(1,3)fucosyltransferase (Fuc-TVII), an enzyme known to be required for CD15s biosynthesis. Less than 1% of HL60-A2 cells expressed CD15s, and only these rare CD15s-expressing cells bound HGE and became infected. After transfection with Fuc-TVII, cells regained CD15s expression, as well as their ability to bind HGE and become infected. Thus, CD15s expression is highly correlated with susceptibility to HGE, and it, and/or a closely related sialylated and α-(1,3) fucosylated molecule, plays a key role in HGE infection, an observation that may help explain the organism's tropism for leukocytes.
Nucleotide pool imbalance and adenosine deaminase deficiency induce alterations of N-region insertions during V(D)J recombination
Creators: name: Gangi-Peterson, Lisa
name: Sorscher, David H.
name: Reynolds, Jon W.
name: Mitchell, Beverly S.
name: Kepler, Thomas B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: Template-independent nucleotide additions (N regions) generated at sites of V(D)J recombination by terminal deoxynucleotidyl transferase (TdT) increase the diversity of antigen receptors. Two inborn errors of purine metabolism, deficiencies of adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP), result in defective lymphoid development and aberrant pools of 2′-deoxynucleotides that are substrates for TdT in lymphoid precursors. We have asked whether selective increases in dATP or dGTP pools result in altered N regions in an extrachromosomal substrate transfected into T-cell or pre–B-cell lines. Exposure of the transfected cells to 2′-deoxyadenosine and an ADA inhibitor increased the dATP pool and resulted in a marked increase in A–T insertions at recombination junctions, with an overall decreased frequency of V(D)J recombination. Sequence analysis of VH-DH-JH junctions from the IgM locus in B-cell lines from ADA-deficient patients demonstrated an increase in A–T insertions equivalent to that found in the transfected cells. In contrast, elevation of dGTP pools, as would occur in PNP deficiency, did not alter the already rich G–C content of N regions. We conclude that the frequency of V(D)J recombination and the composition of N-insertions are influenced by increases in dATP levels, potentially leading to alterations in antigen receptors and aberrant lymphoid development. Alterations in N-region insertions may contribute to the B-cell dysfunction associated with ADA deficiency.
ADVANCING INTERSTELLAR COMMUNICATION - HARNESSING THE POWER OF CODE SYSTEMS
Creators: name: Brandl, Edenilson
Publisher: name: Zenodo
Year: 2023
Subjects: Interstellar Communication
Complex Code Systems
Data Transmission
Error Correction
Ethical Considerations
Adaptability
Quantum Computing
Artificial Intelligence
Space Exploration
Secure Communication
Interstellare Kommunikation
Komplexe Codesysteme
Datenübertragung
Fehlerkorrektur
Ethische Überlegungen
Anpassungsfähigkeit
Quantencomputer
Künstliche Intelligenz
Weltraumforschung
Sichere Kommunikation

description: Interstellar exploration stands at the forefront of human scientific ambition, propelled by the potential for groundbreaking discoveries in the far reaches of the cosmos. Central to this endeavor is the development and deployment of sophisticated complex code systems for interstellar communication. These intricate codes, designed to compress, secure, and transmit diverse forms of information, offer unprecedented efficiency in the face of vast cosmic distances. However, the complexity of these codes presents challenges in interpretation, human-machine alignment, and ethical considerations, necessitating careful navigation of the cosmic communication landscape. This article explores the advantages and challenges of employing complex code systems, emphasizing their role in ensuring efficient data transmission, security, and adaptability in interstellar missions. Furthermore, it underscores the vital need for continuous research and development, interdisciplinary collaboration, and ethical frameworks to guide the responsible use of these codes as humanity embarks on its cosmic odyssey.
 
Die interstellare Erforschung steht an der Spitze der menschlichen wissenschaftlichen Ambitionen und wird durch das Potenzial für bahnbrechende Entdeckungen in den entlegensten Regionen des Kosmos vorangetrieben. Im Mittelpunkt dieses Vorhabens steht die Entwicklung und Bereitstellung hochentwickelter komplexer Codesysteme für die interstellare Kommunikation. Diese komplizierten Codes, die darauf ausgelegt sind, verschiedene Formen von Informationen zu komprimieren, zu sichern und zu übertragen, bieten angesichts der riesigen kosmischen Entfernungen eine beispiellose Effizienz. Die Komplexität dieser Codes stellt jedoch Herausforderungen in Bezug auf Interpretation, Mensch-Maschine-Ausrichtung und ethische Überlegungen dar und erfordert eine sorgfältige Navigation durch die kosmische Kommunikationslandschaft. Dieser Artikel untersucht die Vorteile und Herausforderungen des Einsatzes komplexer Codesysteme und betont deren Rolle bei der Gewährleistung einer effizienten Datenübertragung, Sicherheit und Anpassungsfähigkeit bei interstellaren Missionen. Darüber hinaus unterstreicht es die entscheidende Notwendigkeit kontinuierlicher Forschung und Entwicklung, interdisziplinärer Zusammenarbeit und ethischer Rahmenbedingungen, um den verantwortungsvollen Umgang mit diesen Codes zu leiten, während sich die Menschheit auf ihre kosmische Odyssee begibt.
Star formation timescale in the molecular filament WB 673
Creators: name: Ryabukhina, O. L.
name: Kirsanova, M. S.
name: Henkel, C.
name: Wiebe, D. S.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present observations of ammonia emission lines toward the interstellar filament WB~673 hosting the dense clumps WB~673, WB~668, S233-IR and G173.57+2.43. LTE analysis of the lines allows us to estimate gas kinetic temperature ($\lesssim$ 30~K in all the clumps), number density ($7-17\times10^3$~cm$^{-3}$), and ammonia column density ($\approx 1-1.5\times 10^{15}$~cm$^{-2}$) in the dense clumps. We find signatures of collapse in WB 673 and presence of compact spatially unresolved dense clumps in S233-IR. We reconstruct 1D density and temperature distributions in the clumps and estimate their ages using astrochemical modelling. Considering CO, CS, NH$_3$ and N$_2$H$^+$ molecules (plus HCN and HNC for WB~673), we find a chemical age of $t_{\rm chem}=1-3\times 10^5$~yrs providing the best agreement between the simulated and observed column densities in all the clumps. Therefore, we consider $t_{\rm chem}$ as the chemical age of the entire filament. A long preceding low-density stage of gas accumulation in the astrochemical model would break the agreement between the simulated and observed column densities. We suggest that rapid star formation over a $\sim 10^5$~yrs timescale take place in the filament.
description: 10 pages, 7 figures, accepted for publication in MNRAS
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 6 (118)]
Creators: name: De Ciuidali, Petrus Johannes
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1458
Subjects: subject: Sonstige weltliche Aussteller
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Petrus Johannes de Ciuidali, Sohn des verstorbenen Betinus sowie Onkel väterlicherseits und Vormund des minderjährigen Bernardinus de Ni[...], aus der Nachbarschaft St. Vincentii in Cremona legt in Gegenwart des Ubertus de [...], Doktor der Rechte und iudex rationis des Paulus Amiconibus, seinerseits Podestà von Cremona, ein Inventar der Güter seines Mündels vor.
End to end numerical simulations of the MAORY multiconjugate adaptive optics system
Creators: name: Arcidiacono, Carmelo
name: Schreiber, Laura
name: Bregoli, Giovanni
name: Diolaiti, Emiliano
name: Foppiani, Italo
name: Cosentino, Giuseppe
name: Lombini, Matteo
name: Butler, R. C.
name: Ciliegi, Paolo
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: MAORY is the adaptive optics module of the E-ELT that will feed the MICADO imaging camera through a gravity invariant exit port. MAORY has been foreseen to implement MCAO correction through three high order deformable mirrors driven by the reference signals of six Laser Guide Stars (LGSs) feeding as many Shack-Hartmann Wavefront Sensors. A three Natural Guide Stars (NGSs) system will provide the low order correction. We develop a code for the end-to-end simulation of the MAORY adaptive optics (AO) system in order to obtain high-delity modeling of the system performance. It is based on the IDL language and makes extensively uses of the GPUs. Here we present the architecture of the simulation tool and its achieved and expected performance.
description: 8 pages, 4 figures, presented at SPIE Astronomical Telescopes + Instrumentation 2014 in Montr\'eal, Quebec, Canada, with number 9148-251
Reduced angiotensinogen expression attenuates renal interstitial fibrosis in obstructive nephropathy in mice
Creators: name: Chevalier, Robert L.
name: Kim, Hyung-Suk
name: Smithies, Oliver
name: Thornhill, Barbara A.
name: Fern, Robert J.
name: Yesko, Christine M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: A novel approach was employed to assess the contribution of the renin-angiotensin system (RAS) to obstructive nephropathy in neonatal mice having zero to four functional copies of the angiotensinogen gene (Agt). Two-day-old mice underwent unilateral ureteral obstruction (UUO) or sham operation; 28 days later, renal interstitial fibrosis and tubular atrophy were quantitated. In all Agt genotypes, UUO reduced ipsilateral renal mass and increased that of the opposite kidney. Renal interstitial collagen increased after UUO linearly with Agt expression, from a fractional area of 25% in zero-copy mice to 54% in two-copy mice. Renal expression of transforming growth factor-β1 was increased by ipsilateral UUO in mice expressing Agt, but not in zero-copy mice. However, the prevalence of atrophic tubules due to UUO did not vary with Agt expression. Blood pressure was not different in all groups, except for a reduction in sham zero-copy mice. We conclude that a functional RAS is not necessary for compensatory renal growth. This study demonstrates conclusively that angiotensin regulates at least 50% of the renal interstitial fibrotic response in obstructive nephropathy, an effect independent of systemic hemodynamic changes. Angiotensin-induced fibrosis likely is a mechanism common to the progression of many forms of renal disease.
3alpha clustering in the excited states of 16C
Creators: name: Baba, T.
name: Chiba, Y.
name: Kimura, M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The alpha cluster states of 16C are investigated by using the antisymmetrized molecular dynamics. It is shown that two different types of alpha cluster states exist: triangular and linear-chain states. The former has an approximate isosceles triangular configuration of alpha particles surrounded by four valence neutrons occupying sd-shell, while the latter has the linearly aligned alpha particles with two sd-shell neutrons and two pf-shell neutrons. It is found that the structure of the linear-chain state is qualitatively understood in terms of the 3/2 pi- and 1/2 sigma- molecular orbit as predicted by molecular-orbital model, but there exists non-negligible Be+alpha+2n correlation. The band-head energies of the triangular and linear-chain rotational bands are 8.0 and 15.5 MeV, and the latter is close to the He+Be threshold energy. It is also shown that the linear-chain state becomes the yrast sstate at J=10 with excitation energy 27.8 MeV owing to its very large moment-of-inertia comparable with hyperdeformation.
description: 7 pages, 5 figures
Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E2 receptor
Creators: name: Coffman, Thomas M.
name: Audoly, Laurent P.
name: Tilley, Stephen L.
name: Kim, Hyung-Suk
name: Flannery, Patrick J.
name: Hicks, Elizabeth H.
name: Koller, Beverly H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: Prostaglandins (PGs) are bioactive lipids that modulate a broad spectrum of biologic processes including reproduction and circulatory homeostasis. Although reproductive functions of mammals are influenced by PGs at numerous levels, including ovulation, fertilization, implantation, and decidualization, it is not clear which PGs are involved and whether a single mechanism affects all reproductive functions. Using mice deficient in 1 of 4 prostaglandin E2 (PGE2) receptors — specifically, the EP2 receptor — we show that Ep2–/– females are infertile secondary to failure of the released ovum to become fertilized in vivo. Ep2–/– ova could be fertilized in vitro, suggesting that in addition to previously defined roles, PGs may contribute to the microenvironment in which fertilization takes place. In addition to its effects on reproduction, PGE2 regulates regional blood flow in various vascular beds. However, its role in systemic blood pressure homeostasis is not clear. Mice deficient in the EP2 PGE2 receptor displayed resting systolic blood pressure that was significantly lower than in wild-type controls. Blood pressure increased in these animals when they were placed on a high-salt diet, suggesting that the EP2 receptor may be involved in sodium handling by the kidney. These studies demonstrate that PGE2, acting through the EP2 receptor, exerts potent regulatory effects on two major physiologic processes: blood pressure homeostasis and in vivo fertilization of the ovum.
How close Are Integrable and Non-integrable Models: A Parametric Case Study Based on the Salerno Model
Creators: name: Mithun, Thudiyangal
name: Maluckov, Aleksandra
name: Mančić, Ana
name: Khare, Avinash
name: Kevrekidis, Panayotis G.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Pattern Formation and Solitons (nlin.PS)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: In the present work we revisit the Salerno model as a prototypical system that interpolates between a well-known integrable system (the Ablowitz-Ladik lattice) and an experimentally tractable non-integrable one (the discrete nonlinear Schrödinger model). The question we ask is: for "generic" initial data, how close are the integrable to the non-integrable models? Our more precise formulation of this question is: how well is the constancy of formerly conserved quantities preserved in the non-integrable case? Upon examining this, we find that even slight deviations from integrability can be sensitively felt by measuring these formerly conserved quantities in the case of the Salerno model. However, given that the knowledge of these quantities requires a deep physical and mathematical analysis of the system, we seek a more "generic" diagnostic towards a manifestation of integrability breaking. We argue, based on our Salerno model computations, that the full spectrum of Lyapunov exponents could be a sensitive diagnostic to that effect.
How Many Dissimilarity/Kernel Self Organizing Map Variants Do We Need?
Creators: name: Rossi, Fabrice
Publisher: name: arXiv
Year: 2014
Subjects: subject: Machine Learning (stat.ML)
subject: Machine Learning (cs.LG)
subject: Neural and Evolutionary Computing (cs.NE)
subject: FOS: Computer and information sciences

description: In numerous applicative contexts, data are too rich and too complex to be represented by numerical vectors. A general approach to extend machine learning and data mining techniques to such data is to really on a dissimilarity or on a kernel that measures how different or similar two objects are. This approach has been used to define several variants of the Self Organizing Map (SOM). This paper reviews those variants in using a common set of notations in order to outline differences and similarities between them. It discusses the advantages and drawbacks of the variants, as well as the actual relevance of the dissimilarity/kernel SOM for practical applications.
Adenosine and inosine increase cutaneous vasopermeability by activating A3 receptors on mast cells
Creators: name: Wagoner, Victoria A.
name: Tilley, Stephen L.
name: Koller, Beverly H.
name: Salvatore, Christopher A.
name: Jacobson, Marlene A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: Adenosine has potent effects on both the cardiovascular and immune systems. Exposure of tissues to adenosine results in increased vascular permeability and extravasation of serum proteins. The mechanism by which adenosine brings about these physiological changes is poorly defined. Using mice deficient in the A3 adenosine receptor (A3AR), we show that increases in cutaneous vascular permeability observed after treatment with adenosine or its principal metabolite inosine are mediated through the A3AR. Adenosine fails to increase vascular permeability in mast cell–deficient mice, suggesting that this tissue response to adenosine is mast cell–dependent. Furthermore, this response is independent of activation of the high-affinity IgE receptor (FcεR1) by antigen, as adenosine is equally effective in mediating these changes in FcεR1 β-chain–deficient mice. Together these results support a model in which adenosine and inosine induce changes in vascular permeability indirectly by activating mast cells, which in turn release vasoactive substances. The demonstration in vivo that adenosine, acting through a specific receptor, can provoke degranulation of this important tissue-based effector cell, independent of antigen activation of the high-affinity IgE receptor, supports an important role for this nucleoside in modifying the inflammatory response.
The Scintillating Tail of Comet C/2020 F3 (Neowise)
Creators: name: Fallows, R. A.
name: Forte, B.
name: Mevius, M.
name: Brentjens, M. A.
name: Bassa, C. G.
name: Bisi, M. M.
name: Offringa, A.
name: Shaifullah, G.
name: Tiburzi, C.
name: Vedantham, H.
name: Zucca, P.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Context. The occultation of a radio source by the plasma tail of a comet can be used to probe structure and dynamics in the tail. Such occultations are rare, and the occurrence of scintillation, due to small-scale density variations in the tail, remains somewhat controversial. Aims. A detailed observation taken with the Low-Frequency Array (LOFAR) of a serendipitous occultation of the compact radio source 3C196 by the plasma tail of comet C/2020 F3 (Neowise) is presented. 3C196 tracked almost perpendicularly behind the tail, providing a unique profile cut only a short distance downstream from the cometary nucleus itself. Methods. Interplanetary scintillation (IPS) is observed as the rapid variation of the intensity received of a compact radio source due to density variations in the solar wind. IPS in the signal received from 3C196 was observed for five hours, covering the full transit behind the plasma tail of comet C/2020 F3 (Neowise) on 16 July 2020, and allowing an assessment of the solar wind in which the comet and its tail are embedded. Results. The results reveal a sudden and strong enhancement in scintillation which is unequivocally attributable to the plasma tail. The strongest scintillation is associated with the tail boundaries, weaker scintillation is seen within the tail, and previously-unreported periodic variations in scintillation are noted, possibly associated with individual filaments of plasma. Furthermore, contributions from the solar wind and comet tail are separated to measure a sharp decrease in the velocity of material within the tail, suggesting a steep velocity shear resulting in strong turbulence along the tail boundary
description: Accepted for publication in Astronomy and Astrophysics, 8 pages, 9 figures
Late-time correlation functions in dS$_3$/CFT$_2$ correspondence
Creators: name: Chen, Heng-Yu
name: Chen, Shi
name: Hikida, Yasuaki
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We compute the late-time correlation functions on three-dimensional de Sitter spacetime for a higher-spin gravity theory. For this, we elaborate on the formulation to obtain the wave functional of universe from a dual conformal field theory, which is used to compute the late-time correlation functions. We argue that the relation to direct bulk Feynman diagram computations in the in-in formulation. We furthermore provide a precise prescription to construct a higher-spin dS$_3$ holography as an analytic continuation of Gaberdiel-Gopakumar duality for AdS$_3$. Part of results here were already reported in an earlier letter. We explain the details of their derivations and extend the analysis to more generic cases in this paper. Previously, we have examined two- and three-point functions and a simple four-point correlator at the leading order in Newton constant. Here we also evaluate more complicated four-point correlators. Finally, we study late-time correlators in an alternative limit of dS$_3$/CFT$_2$ with critical level coset, such as, two-point correlator on conical defect geometry. We also examine one-loop corrections to two-point correlator on dS$_3$.
description: 52 pages, 6 figures, minor changes, references added, to appear in JHEP
The Murchison Widefield Array Commissioning Survey: A Low-Frequency Catalogue of 14,110 Compact Radio Sources over 6,100 Square Degrees
Creators: name: Hurley-Walker, Natasha
name: Morgan, John
name: Wayth, Randall B.
name: Hancock, Paul J.
name: Bell, Martin E.
name: Bernardi, Gianni
name: Bhat, Ramesh
name: Briggs, Frank
name: Deshpande, Avinash A.
name: Ewall-Wice, Aaron
name: Feng, Lu
name: Hazelton, Bryna J.
name: Hindson, Luke
name: Jacobs, Daniel C.
name: Kudryavtseva, David L. Kaplan Nadia
name: Lenc, Emil
name: McKinley, Benjamin
name: Mitchell, Daniel
name: Pindor, Bart
name: Procopio, Pietro
name: Oberoi, Divya
name: Offringa, André
name: Ord, Stephen
name: Riding, Jennifer
name: Bowman, Judd D.
name: Cappallo, Roger
name: Corey, Brian
name: Emrich, David
name: Gaensler, B. M.
name: Goeke, Robert
name: Greenhill, Lincoln
name: Hewitt, Jacqueline
name: Johnston-Hollitt, Melanie
name: Kasper, Justin
name: Kratzenberg, Eric
name: Lonsdale, Colin
name: Lynch, Mervyn
name: McWhirter, Russell
name: Morales, Miguel F.
name: Morgan, Edward
name: Prabu, Thiagaraj
name: Rogers, Alan
name: Roshi, Anish
name: Shankar, Udaya
name: Srivani, K.
name: Subrahmanyan, Ravi
name: Tingay, Steven
name: Waterson, Mark
name: Webster, Rachel
name: Whitney, Alan
name: Williams, Andrew
name: Williams, Chris
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: We present the results of an approximately 6,100 square degree 104--196MHz radio sky survey performed with the Murchison Widefield Array during instrument commissioning between 2012 September and 2012 December: the Murchison Widefield Array Commissioning Survey (MWACS). The data were taken as meridian drift scans with two different 32-antenna sub-arrays that were available during the commissioning period. The survey covers approximately 20.5 h < Right Ascension (RA) < 8.5 h, -58 deg < Declination (Dec) < -14 deg over three frequency bands centred on 119, 150 and 180 MHz, with image resolutions of 6--3 arcmin. The catalogue has 3-arcmin angular resolution and a typical noise level of 40 mJy/beam, with reduced sensitivity near the field boundaries and bright sources. We describe the data reduction strategy, based upon mosaiced snapshots, flux density calibration and source-finding method. We present a catalogue of flux density and spectral index measurements for 14,110 sources, extracted from the mosaic, 1,247 of which are sub-components of complexes of sources.
description: 22 pages, 18 figures, accepted to PASA
Reconstruction of charged tracks with Timepix4 ASICs
Creators: name: Akiba, Kazu
name: van Beuzekom, Martin
name: van Beveren, Vincent
name: Byczynski, Wiktor
name: Coco, Victor
name: Collins, Paula
name: Dall'Occo, Elena
name: Dumps, Raphael
name: Evans, Tim
name: Geertsema, Robbert
name: Gkougkousis, Evangelios
name: Halvorsen, Marius
name: van der Heijden, Bas
name: Heijhoff, Kevin
name: Cid, Edgar Lemos
name: Pajero, Tommaso
name: Rolf, David
name: Schindler, Heinrich
Publisher: name: arXiv
Year: 2022
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The design of a detector system comprised of four silicon sensors bump-bonded to Timepix4 ASICs is described together with its data acquisition system, operational infrastructure, and dedicated software. The spatial and temporal performance of the system are assessed with a 180 GeV/c mixed hadron beam at the CERN SPS and reported in detail. Particle tracks are reconstructed using time-space measurements from the four detector planes. The spatial hit resolution is assessed to be $(15.5\pm 0.5)$ $μ$m and $(4.5\pm0.3)$ $μ$m for 100 and 300 $μ$m thick sensors, respectively. The timestamps from the detectors are also measured with fine precision, yielding time resolutions of $(452\pm10)$ ps, $(420\pm10)$ ps, $(639\pm10)$ ps, $(631\pm10)$ ps for the two 100 and two 300 $μ$m thick sensors respectively. These measurements are combined to a track time resolution of $(340\pm 5)$ ps.
description: 15 pages, 15 images in 9 figures
Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A
Creators: name: de Silva, Aravinda M.
name: Anguita, Juan
name: Pal, Utpal
name: Anderson, John F.
name: Montgomery, Ruth R.
name: Lobet, Yves
name: Fish, Durland
name: Fikrig, Erol
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: Borrelia burgdorferi outer surface protein (Osp) A has been used as a Lyme disease vaccine that blocks transmission: OspA antibodies of immune hosts enter ticks during blood feeding and destroy spirochetes before transmission to the host can occur. B. burgdorferi produce OspA in the gut of unfed Ixodes scapularis ticks, and many spirochetes repress OspA production during the feeding process. This preferential expression suggests that OspA may have an important function in the vector. Here we show that OspA mediates spirochete attachment to the tick gut by binding to an I. scapularis protein. The binding domains reside in the central region and COOH-terminus of OspA. OspA also binds to itself, suggesting that spirochete-spirochete interactions may further facilitate adherence in the gut. OspA-mediated attachment in the tick provides a possible mechanism for how stage-specific protein expression can contribute to pathogenesis during the B. burgdorferi natural cycle.
Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2
Creators: name: Langenbach, Robert
name: Sartor, R. Balfour
name: Dieleman, Levinus A.
name: Smithies, Oliver
name: Sellon, Rance
name: Morham, Scott G.
name: Morteau, Olivier
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: To investigate roles in intestinal inflammation for the 2 cyclooxygenase (COX) isoforms, we determined susceptibility to spontaneous and induced acute colitis in mice lacking either the COX-1 or COX-2 isoform. We treated wild-type, COX-1–/–, COX-2–/–, and heterozygous mice with dextran sodium sulfate (DSS) to provoke acute colonic inflammation, and we quantified tissue damage, prostaglandin (PG) E2, and interleukin-1β. No spontaneous gastrointestinal inflammation was detected in mice homozygous for either mutation, despite almost undetectable basal intestinal PGE2 production in COX-1–/– mice. Both COX-1–/– and COX-2–/– mice showed increased susceptibility to a low-dose of DSS that caused mild colonic epithelial injury in wild-type mice. COX-2–/– mice were more susceptible than COX-1–/– mice, and selective pharmacologic blockade of COX-2 potentiated injury in COX-1–/– mice. At a high dose, DSS treatment was fatal to 50% of the animals in each mutant group, but all wild-type mice survived. DSS treatment increased PGE2 intestinal secretion in all groups except COX-2–/– mice. These results demonstrate that COX-1 and COX-2 share a crucial role in the defense of the intestinal mucosa (with inducible COX-2 being perhaps more active during inflammation) and that neither isoform is essential in maintaining mucosal homeostasis in the absence of injurious stimuli.
Enhanced Photonic Maxwell's Demon with Correlated Baths
Creators: name: Zanin, Guilherme L.
name: Antesberger, Michael
name: Jacquet, Maxime J.
name: Ribeiro, Paulo H. Souto
name: Rozema, Lee A.
name: Walther, Philip
Publisher: name: arXiv
Year: 2021
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Maxwell's Demon is at the heart of the interrelation between quantum information processing and thermodynamics. In this thought experiment, a demon generates a temperature gradient between two thermal baths initially at equilibrium by gaining information at the single-particle level and applying classical feed-forward operations, allowing for the extraction of work. Here we implement a photonic version of Maxwell's Demon with active feed-forward in a fibre-based system using ultrafast optical switches. We experimentally show that, if correlations exist between the two thermal baths, the Demon can generate a temperature difference over an order of magnitude larger than without correlations, and so extract more work. Our work demonstrates the great potential of photonic experiments -- which provide a unique degree of control on the system -- to access new regimes in quantum thermodynamics.
description: 25 pages with appendix, 6 figures. Final version published on Quantum
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 6 (119)]
Creators: name: Beltramollus De Burris
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1447
Subjects: subject: Sonstige weltliche Aussteller
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Beltramollus de Burris, Sohn des verstorbenen Anzerinus, früher wohnhaft in Corbetta in der plebs und im comitatus von Mailand, veranlasst Georgius de Bruziano, seine Verpflichtungen gegenüber Jacomollus de Mandello, genannt Ceradus, Sohn des verstorbenen Galuagniolus, früher wohnhaft in Corbetta, zu tilgen, damit Jacomollus seine Schulden ihm begleichen kann.