cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 5: Figure S2. of A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence
Creators: name: Eirini-Stavroula Komseli
name: Pateras, Ioannis
name: ThorbjĂ¸Rn Krejsgaard
name: Stawiski, Konrad
name: Rizou, Sophia
name: Polyzos, Alexander
name: Fani-Marlen Roumelioti
name: Chiourea, Maria
name: Mourkioti, Ioanna
name: Paparouna, Eleni
name: Zampetidis, Christos
name: Gumeni, Sentiljana
name: Trougakos, Ioannis
name: Dafni-Eleftheria Pefani
name: OâNeill, Eric
name: Gagos, Sarantis
name: Eliopoulos, Aristides
name: Fendler, Wojciech
name: Dipanjan Chowdhury
name: Jiri Bartek
name: Vassilis Gorgoulis
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Hematology

description: RB phosphorylation in HBEC CDC6 Tet-ON system. Immunoblot analysis of total and phosphorylated RB levels. CDK4 over-expression in HBEC results in continuous phorsphorylation of RB protein, while induction of CDC6 increased p-RB due to transcriptional down-regulation of p16 [63]. Actin serves as loading control. (PDF 21Â kb)
Use of autologous platelet-rich plasma in androgenetic alopecia in women: a systematic review and meta-analysis
Creators: name: de Oliveira, Antonio Flávio Queiroz
name: Arcanjo, Francisco Plácido Nogueira
name: Rodrigues, Maria Rosineida Paiva
name: Rosa e Silva, Ana Augusta
name: Hall, Peter Richard
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Medicine
Developmental Biology
Science Policy

description: To conduct a systematic review and meta-analysis to verify the efficacy of using autologous platelet-rich plasma (PRP) in female pattern alopecia (FPA). Androgenetic alopecia is the leading cause of hair loss in men andwomen and often impacts self-esteem and quality of life. MEDLINE/PubMed, Cochrane Library, ClinicalTrials.gov, and EMBASE up to May 2021. We identified all studies evaluating the effect of PRP in FPA. A narrative synthesis was performed from data on the efficacy of PRP treatment and adverse effects; quantitative results of PRP use compared to control treatment for female androgenetic alopecia (AGA) were synthesized. The outcomes analyzed were terminal density and hair thickness. Seven articles were selected for this review. Meta-analysis showed that PRP-based interventions were able to increase terminal hair density compared to control (standardized mean difference (SMD)=2.98, 95% confidence intervals (CIs)=1.10, 4.85), with no significant increase in hair thickness (SMD = 1.16, 95% CI= −0.96, 3.28). During and after treatment, no major side effects were reported by patients or researchers. The use of autologous PRP injections in female AGA seems to be promising, with more consistent results on terminal hair density. However, caution is recommended in the interpretation of these results until they can be replicated in larger and more representative samples. PROSPERO registration number CRD42021257154.
Additional file 2: of Metformin, Asian ethnicity and risk of prostate cancer in type 2 diabetes: a systematic review and meta-analysis
Creators: name: Chen, Christopher
name: Eskin, Maxim
name: Eurich, Dean
name: Majumdar, Sumit
name: Johnson, Jeffrey
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Current Metformin Use Vs. No Current Metformin Use in Western-Based Cohort Studies. Comparison of metformin use in western-based cohort studies. (DOCX 25Â kb)
Machining of titanium alloys using WC cutting tools: conventional vs. 3D printed Ti-6AI-4V
Creators: name: Colussi, Jordan
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: The advancement of material science ed to the introduction of 3D printing metals. One of these metals, titanium, is a material with the best weight to strength ration of any metal. As it is expensive to manufacture, 3D printing aims to create intricate components that would normally be uneconomically viable. 3D printing does not yet produce parts with a good quality surface finish, hence requiring machining to get the desired finish. With little information on how to machine the 3D printed material, the thesis sets out to investigate whether the machining parameters typically used for commercial grade are suitable for 3D printed titanium. The project involves lathe machining both commercial grade and SLM 3D printed Ti-6AI-4V and using different cutting tools at different machining parameters to find trends and the most optimal cutting procedure. Electron microscopes (SEM) and compositional analysis (EDS) is used to analyse the specimens to confirm if any diffusion or premature wearing of the carbide occurred. As 3D printed titanium is a much harder material than commercial grade, the coating failed and large built up edges formed on the cutting tools. No diffusion was found on the uncoated cutting tools; the coating on the cutting tool, titanium is the same as the machined metal' it is inconclusive whether diffusion occurred. 3D printing requires decades of innovation before it is at a standard where processing is no longer required. Until then machining will remain as a post processing method. Effective machining will introduce the widespread use of 3D printed specimens and minimise the downsides of such manufacturing methods.
Dual projecting neurons for the laryngeal chemoreflex apnoea
Creators: name: Toor, Rahat Ul Ain Summan
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: The activation of the SLN produces a strong inhibitory response to stop central breathing (apnoea). The neuronal mechanism underlying this apnoeic response, however, remains unknown. A characteristic, non-respiratory burst activity in the expiratory laryngeal motoneurons plays a critical role in producing the apnoeic response. The potential burst-relaying neurons were predicted in the nucleus tractus solitarius (NTS), with simultaneous projections to the Botzinger complex (BotC) to stop central breathing and to the laryngeal motoneurons in the caudal nucleus ambiguus (NA) to close vocal cords. The aim of this project was to provide anatomical evidence to support the existence of such dual-projecting neurons in the NTS. Experiments were performed on 25 anaesthetised Sprague Dawley rats. Four to five days after microinjection of the fluorescent conjugates of cholera toxin B into BotC and unconjugated CTB into the caudal NA, the rats were perfused transcardially with 4% paraformaldehyde. Unconjugated CTB visualized using Goat anti CTB tagged to Alexa-fluor 488 using immunohistochemistry protocol and sections were visualized on Ziess fluorescence microscope. Retrograde labelled neurons in the NTS projecting to BotC and NA were found in the caudal NTS. A small number of double labelled neurons with simultaneous projections to BotC and NA were found ~360um rostral to ~360um caudal to the obex mainly in interstitial and ventrolateral NTS. The study provided anatomical evidences for dual projecting neurons involved in production of apnoeic response and vocal cords adduction.
Additional file 1: of Metformin, Asian ethnicity and risk of prostate cancer in type 2 diabetes: a systematic review and meta-analysis
Creators: name: Chen, Christopher
name: Eskin, Maxim
name: Eurich, Dean
name: Majumdar, Sumit
name: Johnson, Jeffrey
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Current Metformin Use Vs. No Current Metformin Use in Western- and Asian-Based Cohort Studies. Comparison of metformin use in western and asian-based cohort studies. (DOCX 26Â kb)
Additional file 8: of CRABP1, C1QL1 and LCN2 are biomarkers of differentiated thyroid carcinoma, and predict extrathyroidal extension
Creators: name: Celestino, Ricardo
name: Nome, Torfinn
name: Pestana, Ana
name: Hoff, Andreas M.
name: A. Pedro Gonçalves
name: Pereira, Luísa
name: Cavadas, Bruno
name: Eloy, Catarina
name: Bjøro, Trine
name: Sobrinho-Simões, Manuel
name: Skotheim, Rolf I.
name: Soares, Paula
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology
subject: 60506 Virology

description: Prediction and experimental validation of the fusion genes expressed in follicular thyroid carcinomas used in RNA-sequencing. (DOCX 17 kb)
Adipose-derived stem cell exosomes for treatment of dupilumab-related facial redness in patients with atopic dermatitis
Creators: name: Han, Hye Sung
name: Koh, Young Gue
name: Hong, Jun Ki
name: Roh, Yoon Jin
name: Seo, Seong Jun
name: Park, Kui Young
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Dupilumab facial redness (DFR) is a side effect of dupilumab treatment that has only been recently reported. We previously reported on two patients with DFR who were successfully treated with a topical formulation containing human adipose tissue-derived mesenchymal stem cell-derived exosomes (ASCEs). The study aimed to evaluate the efficacy and safety of ASCEs in DFR. We performed 12-week prospective study at single center. Twenty adult atopic dermatitis patients diagnosed with DFR were enrolled. They were treated with a topical application of the exosome formulation every week for five consecutive weeks. After exosome treatment, both the average investigator global assessment score and clinical erythema assessment scale scores decreased. 19 patients (95%) were satisfied with the treatment. Compared to baseline, erythema index at week 4 were decreased by 31, 27, 13, and 25 units on the forehead, chin, right and left cheek respectively. The analysis of stratum corneum samples revealed the expression of IL-1α and human thymic stromal lymphopoietin was suppressed after exosome treatment, whereas filaggrin and vascular endothelial growth factor expression increased. This study suggests topical formulation containing ASCEs can alleviate DFR by downregulating local inflammation and restoring skin barrier function.
Additional file 1 of DNA methylation and expression profiles of placenta and umbilical cord blood reveal the characteristics of gestational diabetes mellitus patients and offspring
Creators: name: Lu, Sha
name: Wang, Jiahao
name: Kakongoma, Nisile
name: Hua, Wen
name: Xu, Jiahui
name: Wang, Yunfei
name: He, Shutao
name: Gu, Hongcang
name: Shi, Jiantao
name: Hu, Wensheng
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file1: Fig. S1 Placenta shows genome-wide methylation alteration associated with glucose metabolism in GDM patients. Unique mapping ratio of placenta and blood samples for A RRBS data and B RNA-seq data. C Genomic distribution of DMRs in placenta. GO pathway enrichment result of placenta for D hyper-DMGs and E hypo-DMGs. The number in brackets represents the number of enriched genes. Fig. S2 Methylation contributes to expression change of genes associated with insulin signaling pathway. A KEGG pathway enrichment analysis of down-DMGs in placenta. B “Cortisol synthesis and secretion” C “Adherens junction,” D “Insulin resistance” and E “Type I diabetes mellitus” pathway enrichment result of placenta expression profile GSEA analysis. F GSEA analysis of placenta DMGs to placenta expression profile. Fig. S3 Alterations for umbilical cord blood were related to insulin secretion and resistance A Genomic distribution of DMRs in umbilical cord blood. B Differences of DMRs mean methylation levels between GDM and control umbilical cord blood samples. Yellow box represents GDM samples and green box represents control samples. *** P value < 0.001, Wilcoxon rank-sum test. Fig. S4 Differential characteristics of primary bile acid synthesis and autophagy between GDM and control samples. Total bile acid concentration between GDM and control sample in A 24 gestational week and B 40 gestational week. Wilcoxon rank-sum test. C ‘primary bile acid biosynthesis’ and D ‘Autophagy’ pathway enrichment result of placenta expression profile GSEA analysis.
Additional file 17: of Metformin, Asian ethnicity and risk of prostate cancer in type 2 diabetes: a systematic review and meta-analysis
Creators: name: Chen, Christopher
name: Eskin, Maxim
name: Eurich, Dean
name: Majumdar, Sumit
name: Johnson, Jeffrey
Publisher: name: figshare
Year: 2018
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Current Metformin Use Vs. No Current Metformin Use in Asian-Based Observational Studies. Comparison of metformin use in Asian-based observational studies. (DOCX 14Â kb)
title: ADCO, Cartulaire de Cîteaux pour les possessions de Chaugey et Maison-Dieu (Fin XVe siècle), Cart. 180 (11 H 755), 83 folios, f. 0084
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2017
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Cartulaire de Cîteaux pour les possessions de Chaugey et Maison-Dieu (Fin XVe siècle), Archives départementales de la Côte-d'Or, Cart. 180 (11 H 755), 83 folios, f. 0084, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les possessions de Chaugey et Maison-Dieu (Fin XVe siècle), Archives départementales de la Côte-d'Or, Cart. 180 (11 H 755), 83 folios, f. 0084, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Changes and innovations for the surgical management of intracranial aneurysms
Creators: name: Lai, Leon Tat
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Advancements have been made in the understanding of intracranial aneurysms and their management. Surgical strategies have evolved, with many principles revisited, many approaches reconsidered, and many frontiers successfully conquered. The global expansion of endovascular services has challenged the existence of aneurysm surgery, changing the complexity of aneurysm case mix and volume that are presently referred for surgical repair. As in the evolution of any type of procedures, innovations arise from the criticisms of currently available techniques. The development and technological maturation of endoscopic surgery in recent years have emboldened neurosurgeons, who are already familiar with the transsphenoidal techniques, to consider expanded endonasal approaches for the treatment of more complex cranial base pathologies. The surgical relevance of an endoscopic transnasal access for the clip reconstruction of intracranial aneurysms is a natural extension of the philosophy underlying this evolution. This thesis presents a compilation of scientific investigations (through literature reviews, clinical studies and preclinical experiments) that examined the history, evolution and contemporary innovations in the surgical management of intracranial aneurysms. The results of this study have the potential to expand the therapeutic options for intracranial aneuryms.
Fuzzy Clustering Data Given on the Ordinal Scale Based on Membership and Likelihood Functions Sharing
Creators: name: Hu, Zhengbing
name: Bodyanskiy, Yevgeniy V.
name: Tyshchenko, Oleksii K.
name: Samitova, Viktoriia O.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: A task of clustering data given in the ordinal scale under conditions of overlapping clusters has been considered. It's proposed to use an approach based on memberhsip and likelihood functions sharing. A number of performed experiments proved effectiveness of the proposed method. The proposed method is characterized by robustness to outliers due to a way of ordering values while constructing membership functions.
description: International Journal of Intelligent Systems and Applications(IJISA), Vol. 9, No. 2, February 2017
Disorder enabled band structure engineering of a topological insulator surface
Creators: name: Xu, Yishuai
name: Chiu, Janet
name: Miao, Lin
name: He, Haowei
name: Alpichshev, Zhanybek
name: Kapitulnik, A.
name: Biswas, Rudro R.
name: Wray, L. Andrew
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Three dimensional topological insulators are bulk insulators with $\mathbf{Z}_2$ topological electronic order that gives rise to conducting light-like surface states. These surface electrons are exceptionally resistant to localization by non-magnetic disorder, and have been adopted as the basis for a wide range of proposals to achieve new quasiparticle species and device functionality. Recent studies have yielded a surprise by showing that in spite of resisting localization, topological insulator surface electrons can be reshaped by defects into distinctive resonance states. Here we use numerical simulations and scanning tunneling microscopy data to show that these resonance states have significance well beyond the localized regime usually associated with impurity bands. At native densities in the model Bi$_2$X$_3$ (X=Bi, Te) compounds, defect resonance states are predicted to generate a new quantum basis for an emergent electron gas that supports diffusive electrical transport.
title: Exécution d'une truie coupable de meurtre - Archives départementales de la Côte-d'Or, E 2166-74 0004
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: subject: LaMOP
subject: Laboratoire de médiévistique occidentale de Paris

description: Commune d’Is-sur-Tille, autorisation accordée par le duc de Bourgogne au seigneur de la ville d’exécuter une truie coupable d’avoir tué un enfant
Document transcrit dans le cadre des ateliers de paléographie du Chancelier Rolin des Archives départements des Côtes d’Or
Page : 4/4
description: Source: https://archives.cotedor.fr/v2/site/AD21/web/media/04_apprendre/02_ateliers_chancelier_rolin/paleographie/debutants/2010_2011/document_12.pdf
description: Source: https://www.nakala.fr/10.34847/nkl.6904sa0w
description: Exécution d'une truie coupable de meurtre - Archives départementales de la Côte-d'Or, E 2166-74 0004
Denaturing Kinship: Gender, Science, and Politics in Urban China's Pet Ownership
Creators: name: Liu, Yuer
name: Kohrman, Matthew
name: Fullwiley, Duana
Publisher: name: Stanford Digital Repository
Year: 2024
Subjects: Kinship
Gender
Pet Ownership
Urban China

description: Drawing on ethnographic fieldwork conducted in Ruichong veterinary hospital in Shanghai, this thesis explores the intersections of gender, science, and politics through the lens of pet ownership in urban China. Amidst a booming pet industry and evolving family structures, it examines how urban middle-class women, particularly those born under the One-Child Policy, are redefining kinship by integrating pets into their families.
Chapter 1 delves into the scrutiny faced by 'single-child pet moms,' predominantly childless, middle-class women aged 20 to 40, within contemporary biopolitical and economic frameworks. Pets serve both as strategies for managing elder care and as a means to sustain life amidst personal challenges and societal anxieties. The chapter elucidates the roles pets play in contemporary family settings and the reproduction of life, thereby uncovering the nuances of urban womanhood in China. Engaging with Lauren Berlant's concepts of 'lateral agency' and 'slow death,' this chapter complicates existing theories on agency and power.
Chapter 2 thoroughly examines the dynamics within the veterinary ophthalmology hospital, interrogating the complex interrelations among pet owners, their pets, and veterinary professionals. The focus is primarily on the analysis of 'failed' medical interventions to uncover the ontological shifts experienced by pets as they transition from being regarded as family members to medical subjects. This analysis explores how medical narratives reconfigure the identities of pets and humans and consequently alter kinship dynamics. The chapter explores the intricate negotiations of trust and ethical considerations, thereby contributing to the discourse on animal agency and veterinary ethics in the urban Chinese context.
Collectively, these chapters illustrate the reciprocal influence between human and animal identities and ontologies, both within familial dynamics and medicalized settings. This interplay reveals a kinship structure that surpasses simplistic dichotomous classifications, advocating for a more intricate understanding of interspecies relationality in the context of urban Chinese socioeconomic realities.
The clinical relevance of dupilumab serum concentration in patients with atopic dermatitis: a two-center prospective cohort study
Creators: name: Bosma, Angela L.
name: Gerbens, Louise A.A.
name: Khattabi, Hajar El
name: Loeff, Floris C.
name: Duckworth, Michael
name: Woolf, Richard T.
name: PhD, MBChB
name: Rispens, Theo
name: Smith, Catherine H.
name: Spuls, Phyllis I.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Virology

description: Dupilumab is prescribed in one dosage across adult atopic dermatitis patients. Differences in drug exposure may explain variation in treatment response. Investigating the clinical relevance of dupilumab serum concentration in atopic dermatitis in real-world practice. In two centres (Netherlands, UK), adults treated with dupilumab for atopic dermatitis were evaluated for effectiveness and safety pre-treatment and at 2, 12, 24 and 48 weeks; trough serum samples were analysed for dupilumab concentration at corresponding time points. In 149 patients, median dupilumab levels during follow-up ranged from 57.4-72.4μg/mL. Levels showed high inter-patient and low intra-patient variability. No correlation was found between levels and ΔEASI. At 2 weeks, levels of ≥64.1μg/mL predict EASI ≤ 7 at 24 weeks (specificity:100%, sensitivity:60%;p = 0.022). At 12 weeks, ≤32.7μg/mL predicts EASI > 7 at 24 weeks (sensitivity:95%, specificity:26%;p = 0.011). Inverse correlations were found between baseline EASI and levels at 2, 12 and 24 weeks (r=-0.25-0.36;p ≤ 0.023). Low levels were particularly observed in patients with adverse events, treatment interval deviation and discontinuation. At the on-label dosage, the measured range of dupilumab levels does not seem to yield differences in treatment effectiveness. However, disease activity does seem to influence dupilumab levels - higher baseline disease activity results in lower levels at follow-up.
Treatment persistence of interleukin-17 inhibitor class drugs among patients with psoriasis in Japan: a retrospective database study
Creators: name: Wang, Chaochen
name: Torisu-Itakura, Hitoe
name: Hanada, Takao
name: Matsuo, Takashi
name: Cai, Zhihong
name: Osaga, Satoshi
name: Aranishi, Toshihiko
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Mental Health

description: Real-world evidence on persistence of interleukin-17 inhibitors (IL-17i) as a drug class among Japanese patients with psoriasis is lacking. Hence, we aimed to describe persistence rates of IL-17is among patients with psoriasis including psoriasis vulgaris (PsO), psoriatic arthritis (PsA), and generalized pustular psoriasis (GPP) or erythrodermic psoriasis (EP) in Japan. We analyzed claims data from the Medical Data Vision database. Patients ≥15 years old with a psoriasis diagnosis and an IL-17i prescription between November 2016 and August 2020 were included and followed through August 2021. Persistence rates of the IL-17i class among patients with psoriasis and its subtypes (PsO, PsA, and GPP or EP), and persistence rates of ixekizumab, secukinumab, or brodalumab among patients with PsO or PsA were analyzed using Kaplan-Meier method. Analyses were conducted in the bio-naïve and bio-experienced subgroups. The IL-17i class had >50% persistence rates up to 36 months among patients with psoriasis and its subtypes (PsO, PsA, and GPP or EP). 36-Month persistence rates for ixekizumab, secukinumab, and brodalumab were 46.2% to 57.7% in patients with PsO and 43.0% to 48.4% in patients with PsA. Across analyses, bio-naïve patients demonstrated similar or greater persistence rates than bio-experienced patients. IL-17is’ persistence rates over 36 months were >50% among patients with psoriasis and its subtypes (PsO, PsA, and GPP or EP) in Japan.
Additional file 7: Table S4. of CRABP1, C1QL1 and LCN2 are biomarkers of differentiated thyroid carcinoma, and predict extrathyroidal extension
Creators: name: Celestino, Ricardo
name: Nome, Torfinn
name: Pestana, Ana
name: Hoff, Andreas M.
name: A. Pedro Gonçalves
name: Pereira, Luísa
name: Cavadas, Bruno
name: Eloy, Catarina
name: Bjøro, Trine
name: Sobrinho-Simões, Manuel
name: Skotheim, Rolf I.
name: Soares, Paula
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer
subject: Plant Biology
subject: 60506 Virology

description: Oligonucleotide primers used in RT-PCR to detect the fusion genes. (DOCX 13 kb)
Gain enhanced Fano resonance in a coupled photonic crystal cavity-waveguide structure
Creators: name: Zhao, Yanhui
name: Qian, Chenjiang
name: Qiu, Kangsheng
name: Tang, Jing
name: Sun, Yue
name: Jin, Kuijuan
name: Xu, Xiulai
Publisher: name: arXiv
Year: 2016
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Systems with coupled cavities and waveguides have been demonstrated as optical switches and optical sensors. To optimize the functionalities of these optical devices, Fano resonance with asymmetric and steep spectral line shape has been used. We theoretically propose a coupled photonic crystal cavity-waveguide structure to achieve Fano resonance by placing partially reflecting elements in waveguide. To enhance Fano resonance, optical gain material is introduced into the cavity. As the gain increases, the transmission line shape becomes steepened and the transmissivity can be six times enhanced, giving a large contrast by a small frequency shift. It is prospected that the gain enhanced Fano resonance is very useful for optical switches and optical sensors.
description: 16 pages, 5 figures
Complete cosmological evolution model of a classical scalar field with a Higgs potential. III. Features of phase trajectory flows
Creators: name: Ignat'ev, Yu. G.
name: Samigullina, A. R.
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The flows of phase trajectories of cosmological models based on the vacuum classical Higgs field and their behavior on the Einstein-Higgs surface near singular points of a dynamical system are investigated by numerical simulation. The influence of the singular points on the process of phase flow splitting is shown and the efficiency of the Einstein-Higgs hypersurface application is demonstrated.
description: 7 pages, 13 figures, 4 references
Giving selflessly and building oneself: a study of social entrepreneurial motives and rewards
Creators: name: Ruskin, Jennifer
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Social entrepreneurs employ market-based methods to fill gaps in the provision of social goods or services. In the growing field of academic research on social entrepreneurship, surprisingly few studies investigate the factors that drive social entrepreneurs to create value for others. This thesis presents two qualitative studies and one quantitative study that examine motives experienced by social entrepreneurs and the rewards they receive. The first two studies are based on a qualitative, phenomenon-driven case study exploring the motives and rewards for social entrepreneurship. In contrast to the social entrepreneurship literature, findings from these studies suggest that social entrepreneurs experience both self- and other-oriented motives. Further, the distinct emotions of passion and frustration precede self-oriented motivation, while the emotions of sympathy and empathy precede other-oriented motivation. Having a successful venture is a key reward for social entrepreneurs and awareness that the venture is achieving social aims contributes to social entrepreneurs’ experience of personal growth and well-being. Although financial rewards are not primary drivers of social entrepreneurship, there seems to be a threshold of financial returns, below which it is difficult to sustain engagement in the venture. The third study is a quantitative enquiry of social entrepreneurial motivation. Data from an online survey of 193 social and commercial entrepreneurs show strong, direct relationships between self-oriented motivation and value placed on financial rewards, and between other-oriented motivation and the intrinsic rewards of hedonic and eudaimonic happiness. Moreover, entrepreneurs in ventures with high social emphasis place more importance on intrinsic rewards. As social entrepreneurship becomes an increasingly important part of the economy’s third sector, it is critical to understand what drives and maintains engagement in social ventures. Having a better understanding of social entrepreneurial motivation may enablesocial entrepreneurs to build satisfying ventures that sustain engagement. From an academic perspective, new frameworks for understanding social entrepreneurial motivation contribute to this emerging field of research.This thesis presents two qualitative studies and one quantitative study that examine motives experienced by social entrepreneurs and the rewards they receive.
A systematic review investigating at what proportion clinical images are shared in prospective randomized controlled trials involving patients with psoriasis and biological agents
Creators: name: Polesie, Sam
name: Alinaghi, Farzad
name: Egeberg, Alexander
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Science Policy
subject: Mental Health

description: For many patients including those with psoriasis, scientific manuscripts comprising clinical outcomes including psoriasis area severity index (PASI) and/or physician global assessment (PGA) may be difficult to understand. However, most patients can relate to images at baseline and follow-up, particularly for dermatological diseases. This study aimed to assess the proportion of shared clinical images in psoriasis trials. A systematic review adhering to the PRISMA guidelines was performed. The review was limited to randomized controlled trials, and among these, only investigations involving biological agents for treatment of psoriasis were included. The Embase, MEDLINE and Scopus databases were searched for eligible studies published from inception to October 26, 2021. In total, 152 studies were included. When combining these, 62,871 patients were randomized. Overall, 203 images were shared depicting 60 patients in the manuscripts yielding an overall sharing rate of 0.1%. Patient images are seldom incorporated in clinical trial manuscripts which impairs interpretation for patients. Inclusion of image material would strengthen the patients’ perspective and understanding on what treatment effects that can be expected. As such, this systematic review should be an invitation to the pharmaceutical industry, other sponsors, and editorial offices to improve easy transfer of information to patients using image data.
Additional file 6: Table S3. of CRABP1, C1QL1 and LCN2 are biomarkers of differentiated thyroid carcinoma, and predict extrathyroidal extension
Creators: name: Celestino, Ricardo
name: Nome, Torfinn
name: Pestana, Ana
name: Hoff, Andreas M.
name: A. Pedro Gonçalves
name: Pereira, Luísa
name: Cavadas, Bruno
name: Eloy, Catarina
name: Bjøro, Trine
name: Sobrinho-Simões, Manuel
name: Skotheim, Rolf I.
name: Soares, Paula
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Developmental Biology
subject: Plant Biology
subject: 60506 Virology

description: Fusion genes selected by customized filtering steps and experimentally validated by RT-PCR and Sanger sequencing. FTC, follicular thyroid carcinoma; ORF, open reading frame. (DOCX 15 kb)
Effect of magnetic field on dilepton production in a hot plasma
Creators: name: Bandyopadhyay, Aritra
name: Mallik, S.
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Noncentral collision of heavy ions can generate large magnetic field in its neighbourhood. We describe a method to calculate the effect of this field on the dilepton emission rate from the colliding region, when it reaches thermal equilibrium. It is calculated in the real time method of thermal field theory. We find that the rate is affected significantly only for lower momenta of dileptons.
description: 14 pages, 5 figures; Accepted for publication in Phys. Rev. D
On the performance of preconditioned methods to solve \(L^p\)-norm phase unwrapping
Creators: name: Legarda-Saenz, Ricardo
name: Brito-Loeza, Carlos
name: Espinosa-Romero, Arturo
Publisher: name: arXiv
Year: 2022
Subjects: subject: Numerical Analysis (math.NA)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences
subject: 65K10, 78-10

description: In this paper, we analyze and evaluate suitable preconditioning techniques to improve the performance of the $L^p$-norm phase unwrapping method. We consider five preconditioning techniques commonly found in the literature, and analyze their performance with different sizes of wrapped-phase maps. Keywords.- Phase unwrapping, $L^p$-norm based method, Preconditioning techniques.
Epistemic justice: confronting implicit bias, explicit prejudice, and epistemiology of oppression
Creators: name: Mehdi, Muhammad
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: This thesis attempts to further develop Fricker's notion of epistemic justice. Fricker defines epistemic justice, in the Aristotelian tradition, as a virtue of character. However, given that epistemic justice is also a corrective measure to the various forms of epistemic injustice, it seems as an inadequate corrective response in its current individualistic and virtue-theoretic form. Keeping the virtue-theoretic form of epistemic justice - though briefly alluding to its inadequacies as well, I explore various social roles that can cultivate this virtue as a corrective to epistemic injustice. I do so by horizontally and vertically expanding the social landscape where epistemic injustice occurs. Horizontal expansion reveals that every instance of epistemic injustice includes three distinct social roles that consists of the perpetrator, the victim and possibly the audience or witnesses of the injustice. Certain epistemic justice virtues can be construed for each of these roles. Vertical expansion reveals three distinct layers in the social system where epistemic injustice can be located, namely the layer where individual agents perform, the layer where collectives are formed and operate, and the broader social system. A socially situated view op epistemic injustice allows imagining non-individualistic virtues, such as the virtues of groups and the virtues that exist in the social systems.
Oedometric compression of a granular material: computation of energies involved during breakage with a discrete element modelling
Creators: name: Nader, François
name: Silvani, Claire
name: Djeran-Maigre, Irini
Publisher: name: arXiv
Year: 2022
Subjects: subject: Classical Physics (physics.class-ph)
subject: FOS: Physical sciences

description: A numerical model able to simulate the grain breakage with the discrete element method, using the "Non-Smooth Contact Dynamics" is presented. The model reproduces 3D grains having complex shapes and is tested in single grain and in oedometric compressions. Numerical simulations are then carried out to evaluate the different energies active during breakage (surface creation and redistribution energies). The surface creation energy is estimated. Results are closed to the ones found in the literature.
Additional file 16: of Metformin, Asian ethnicity and risk of prostate cancer in type 2 diabetes: a systematic review and meta-analysis
Creators: name: Chen, Christopher
name: Eskin, Maxim
name: Eurich, Dean
name: Majumdar, Sumit
name: Johnson, Jeffrey
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Current Metformin Use Vs. No Current Metformin Use in Western- Based Observational Studies. Comparison of metformin use in Western-based observational studies. (DOCX 18Â kb)
Effects and safety of fire needle adjuvant chemical peels therapy in acne vulgaris: a systematic review and meta-analysis
Creators: name: Zhang, Jianfeng
name: Lin, Peng
name: Guo, Chenqi
name: Ma, Cong
name: Liu, Yiting
name: Wang, Yingdong
name: Zhang, Yu
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Acne vulgaris (AV) is a common skin disease. Fire needle is a method of quickly piercing the local skin lesions with red-hot needles for AV. This work aimed to evaluate the efficacy and safety of fire needle combined with chemical peels for AV. Eight databases including PubMed, EMBASE, Cochrane Library, Web of Science, China National Knowledge Internet, Wanfang, Sinomed, and VIP databases were searched to enrolled randomized controlled trials (RCTs) comparing fire needle therapy combined with chemical peels with chemical peels alone. The risk of bias was evaluated by the Cochrane Collaboration’s tool. Statistical analysis was completed by RevMan 5.3 and Stata 14.0. Altogether 18 studies including 1213 patients were enrolled. Compared with chemical peels alone, fire needle adjuvant chemical peels therapy improved the total effective rate (RR = 1.37,95% CI [1.26,1.48], p < 0.00001) and skin lesions (MD = −2.11, 95% CI [−2.74, −1.47], p < 0.00001), and reduced the recurrence rate (RR  = 0.50,95% CI [0.33,0.76], p = 0.0009).The application of fire needle was associated with few adverse reactions, all of which were well tolerated and transient. Fire needle adjuvant chemical peels therapy is effective and safe for AV. Nevertheless, more large-scale, well-designed clinical studies are warranted to provide evidence-based medical support.
Haldane relation for interacting dimers
Creators: name: Giuliani, Alessandro
name: Mastropietro, Vieri
name: Toninelli, Fabio Lucio
Publisher: name: arXiv
Year: 2016
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Mathematical Physics (math-ph)
subject: Probability (math.PR)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We consider a model of weakly interacting, close-packed, dimers on the two-dimensional square lattice. In a previous paper, we computed both the multipoint dimer correlations, which display non-trivial critical exponents, continuously varying with the interaction strength; and the height fluctuations, which, after proper coarse graining and rescaling, converge to the massless Gaussian field with a suitable interaction-dependent pre-factor (`amplitude'). In this paper, we prove the identity between the critical exponent of the two-point dimer correlation and the amplitude of this massless Gaussian field. This identity is the restatement, in the context of interacting dimers, of one of the Haldane universality relations, part of his Luttinger liquid conjecture, originally formulated in the context of one-dimensional interacting Fermi systems. Its validity is a strong confirmation of the effective massless Gaussian field description of the interacting dimer model, which was guessed on the basis of formal bosonization arguments. We also conjecture that a certain discrete curve defined at the lattice level via the Temperley bijection converges in the scaling limit to an SLE$_κ$ process, with $κ$ depending non-trivially on the interaction and related in a simple way to the amplitude of the limiting Gaussian field.
description: 43 pages, 3 figures
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VIII, Cart. 192 (11 H 77), 295 folios, f. 0170r
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VIII, Archives départementales de la Côte-d'Or, Cart. 192 (11 H 77), 295 folios, f. 0170r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VIII, Archives départementales de la Côte-d'Or, Cart. 192 (11 H 77), 295 folios, f. 0170r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
MOESM1 of A high-density genetic map constructed using specific length amplified fragment (SLAF) sequencing and QTL mapping of seed-related traits in sesame (Sesamum indicum L.)
Creators: name: Du, Hua
name: Zhang, Haiyang
name: Wei, Libin
name: Li, Chun
name: Duan, Yinghui
name: Wang, Huili
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Additional file 1: Table S1. Pairwise correlation coefficients between thousand seed weight and seed size traits for sesame under two environments. *Significant at P ≤ 0.05, **Significant at P ≤ 0.01; tsw, thousand seed weight; sl, seed length; sw, seed width; lwr, length-to-width ratio; sp., seed perimeter; sd, seed diameter; sa, seed area; sc, seed circularity.
Additional file 15: of Metformin, Asian ethnicity and risk of prostate cancer in type 2 diabetes: a systematic review and meta-analysis
Creators: name: Chen, Christopher
name: Eskin, Maxim
name: Eurich, Dean
name: Majumdar, Sumit
name: Johnson, Jeffrey
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Current Metformin Use Vs. No Current Metformin Use in Western- and Asian-Based Observational Studies. Comparison of metformin use in Western- and Asian-based observational studies. (DOCX 26Â kb)
Ballistic Aggregation in Systems of Inelastic Particles: Cluster growth, structure and aging
Creators: name: Paul, Subhajit
name: Das, Subir K.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We study far-from-equilibrium dynamics in models of freely cooling granular gas and ballistically aggregating compact clusters. For both the cases, from event driven molecular dynamics simulations we have presented detailed results on structure and dynamics in space dimensions $d=1$ and $2$. Via appropriate analyses it has been confirmed that the ballistic aggregation mechanism applies in $d=1$ granular gases as well. Aging phenomena for this mechanism, in both the dimensions, have been studied via the two-time density autocorrelation function. This quantity is demonstrated to exhibit scaling property similar to that in the standard phase transition kinetics. The corresponding functional forms have been quantified and discussed in connection with the structural properties. Our results on aging establish a more complete equivalence between the granular gas and the ballistic aggregation models in $d=1$.