title: ÐÐ»Ð¸ÑÐ½Ð¸Ðµ Ð¼ÑÑÐ°ÑÐ¸Ð¸ Ð² Ð³ÐµÐ½Ðµ ACF1 Ð½Ð° Ð¿ÑÐ¾ÑÐµÑÑ ÑÐµÐ¿Ð°ÑÐ°ÑÐ¸Ð¸ Ð² ÑÐ¼Ð±ÑÐ¸Ð¾Ð³ÐµÐ½ÐµÐ·Ðµ Ð´ÑÐ¾Ð·Ð¾ÑÐ¸Ð»Ñ
title: Ð¼Ð°Ð³Ð¸ÑÑÐµÑÑÐºÐ°Ñ Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ñ
titleType: Subtitle
Creators: name: ÐÑÐ¾ÑÐ°ÑÐ¾Ð², ÐÐ»ÐµÐºÑÐ°Ð½Ð´Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2016
Subjects: ÐÐ»ÐµÑÐºÐ° (Ð±Ð¸Ð¾Ð»)
ÐÑÐºÐ»ÐµÐ¸Ð½Ð¾Ð²ÑÐµ ÐºÐ¸ÑÐ»Ð¾ÑÑ
ÐÐ¾Ð½Ð¸Ð·Ð¸ÑÑÑÑÐ¸Ðµ Ð¸Ð·Ð»ÑÑÐµÐ½Ð¸Ñ
Ð¼ÑÑÐ°ÑÐ¸Ð¸
ÑÐ¼Ð±ÑÐ¸Ð¾Ð³ÐµÐ½ÐµÐ·
ÐºÐ¾Ð½ÑÐ¾ÐºÐ°Ð»ÑÐ½Ð°Ñ Ð¼Ð¸ÐºÑÐ¾ÑÐºÐ¾Ð¿Ð¸Ñ
mutations
embryogenesis
confocal microscopy

description: Ð Ð¾Ð»Ñ ÐÐ¢Ð¤-Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼ÑÑ ÑÐ°ÐºÑÐ¾ÑÐ¾Ð² Ð² ÑÐ±Ð¾ÑÐºÐµ ÑÑÐ¾Ð¼Ð°ÑÐ¸Ð½Ð° Ð½Ð° Ð´Ð°Ð½Ð½ÑÐ¹ Ð¼Ð¾Ð¼ÐµÐ½Ñ Ð¸Ð·ÑÑÐµÐ½Ð° Ð¿Ð»Ð¾ÑÐ¾. ÐÐ´Ð½Ð¸Ð¼ Ð¸Ð· ÑÐ°ÐºÑÐ¾ÑÐ¾Ð², Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½Ð¾ ÑÑÐ°ÑÑÐ²ÑÑÑÐ¸Ñ Ð² ÑÐ±Ð¾ÑÐºÐµ ÑÑÐ¾Ð¼Ð°ÑÐ¸Ð½Ð°, ÑÐ²Ð»ÑÐµÑÑÑ ÑÐ°ÐºÑÐ¾Ñ ACF. Ð¦ÐµÐ»ÑÑ ÑÐ°Ð±Ð¾ÑÑ ÑÐ²Ð»ÑÐ»Ð¾ÑÑ Ð¸Ð·ÑÑÐµÐ½Ð¸Ðµ Ð²Ð»Ð¸ÑÐ½Ð¸Ñ Ð¼ÑÑÐ°ÑÐ¸Ð¸ Ð² Ð³ÐµÐ½Ðµ ÑÑÐ±ÑÐµÐ´Ð¸Ð½Ð¸ÑÑ Acf1 ÐÐ¢Ð¤-Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾Ð³Ð¾ ÑÐ°ÐºÑÐ¾ÑÐ° ÑÐ±Ð¾ÑÐºÐ¸ ÑÑÐ¾Ð¼Ð°ÑÐ¸Ð½Ð° ACF Ð½Ð° ÑÑÑÐµÐºÑÑ, Ð²ÑÐ·ÑÐ²Ð°ÐµÐ¼ÑÐµ Ð´ÐµÐ¹ÑÑÐ²Ð¸ÐµÐ¼ Ð¸Ð¾Ð½Ð¸Ð·Ð¸ÑÑÑÑÐµÐ¹ ÑÐ°Ð´Ð¸Ð°ÑÐ¸Ð¸ Ð² ÑÐ°Ð½Ð½ÐµÐ¼ ÑÐ¼Ð±ÑÐ¸Ð¾Ð³ÐµÐ½ÐµÐ·Ðµ Ð´ÑÐ¾Ð·Ð¾ÑÐ¸Ð»Ñ. Ð¡ Ð¿Ð¾Ð¼Ð¾ÑÑÑ Ð¼ÐµÑÐ¾Ð´Ð° ÑÐºÐ°Ð½Ð¸ÑÑÑÑÐµÐ¹ ÐºÐ¾Ð½ÑÐ¾ÐºÐ°Ð»ÑÐ½Ð¾Ð¹ Ð¼Ð¸ÐºÑÐ¾ÑÐºÐ¾Ð¿Ð¸Ð¸ Ð¾ÑÐµÐ½ÐµÐ½Ð° Ð¿ÑÐ¾Ð´Ð¾Ð»Ð¶Ð¸ÑÐµÐ»ÑÐ½Ð¾ÑÑÑ S-ÑÐ°Ð·Ñ ÐºÐ»ÐµÑÐ¾ÑÐ½Ð¾Ð³Ð¾ ÑÐ¸ÐºÐ»Ð°, Ð¿Ð¾Ð»Ð½Ð°Ñ Ð¿ÑÐ¾Ð´Ð¾Ð»Ð¶Ð¸ÑÐµÐ»ÑÐ½Ð¾ÑÑÑ ÐºÐ»ÐµÑÐ¾ÑÐ½Ð¾Ð³Ð¾ ÑÐ¸ÐºÐ»Ð° Ð½Ð° ÑÑÐ°Ð¿Ðµ ÑÐ°Ð½Ð½ÐµÐ³Ð¾ ÑÐ¼Ð±ÑÐ¸Ð¾Ð³ÐµÐ½ÐµÐ·Ð° Ñ ÑÐ¼Ð±ÑÐ¸Ð¾Ð½Ð¾Ð² Ð´ÑÐ¾Ð·Ð¾ÑÐ¸Ð»Ñ Ð»Ð¸Ð½Ð¸Ð¹ Ð´Ð¸ÐºÐ¾Ð³Ð¾ ÑÐ¸Ð¿Ð° Ð¸ Ð¼ÑÑÐ°Ð½ÑÐ¾Ð² Ð¿Ð¾ Ð³ÐµÐ½Ñ Acf1. Ð¢Ð°ÐºÐ¶Ðµ Ð¿Ð¾Ð»ÑÑÐµÐ½Ñ Ð´Ð°Ð½Ð½ÑÐµ Ð¿Ð¾ Ð³Ð¸Ð±ÐµÐ»Ð¸ ÑÐ¾Ð¼Ð°ÑÐ¸ÑÐµÑÐºÐ¸Ñ ÑÐ´ÐµÑ ÑÐ¼Ð±ÑÐ¸Ð¾Ð½Ð¾Ð² Ð´ÑÐ¾Ð·Ð¾ÑÐ¸Ð»Ñ Ð»Ð¸Ð½Ð¸Ð¹ Ð´Ð¸ÐºÐ¾Ð³Ð¾ ÑÐ¸Ð¿Ð° Ð¸ Ð¼ÑÑÐ°Ð½ÑÐ¾Ð² Ð¿Ð¾ Ð³ÐµÐ½Ñ Acf1. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ Ð´Ð°Ð½Ð½ÑÐµ ÑÐ²Ð¸Ð´ÐµÑÐµÐ»ÑÑÑÐ²ÑÑÑ Ð¾ ÑÐ¾ÐºÑÐ°ÑÐµÐ½Ð¸Ð¸ Ð¿ÑÐ¾Ð´Ð¾Ð»Ð¶Ð¸ÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ S-ÑÐ°Ð·Ñ ÐºÐ»ÐµÑÐ¾ÑÐ½Ð¾Ð³Ð¾ ÑÐ¸ÐºÐ»Ð° Ñ Ð¼ÑÑÐ°Ð½ÑÐ¾Ð² Ð¿Ð¾ Ð³ÐµÐ½Ñ Acf1, Ð¿Ð¾ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ñ Ñ Ð»Ð¸Ð½Ð¸ÐµÐ¹ Ð´Ð¸ÐºÐ¾Ð³Ð¾ ÑÐ¸Ð¿Ð°, Ð±ÐµÐ· Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð²Ð½ÐµÑÐ½Ð¸Ñ ÐÐÐ-Ð¿Ð¾Ð²ÑÐµÐ¶Ð´Ð°ÑÑÐ¸Ñ ÑÐ°ÐºÑÐ¾ÑÐ¾Ð² Ð¸ Ð¿Ð¾ÑÐ»Ðµ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð¸Ð¾Ð½Ð¸Ð·Ð¸ÑÑÑÑÐµÐ³Ð¾ Ð¸Ð·Ð»ÑÑÐµÐ½Ð¸Ñ. ÐÐ¸Ð±ÐµÐ»Ñ Ð±Ð¾Ð»ÑÑÐµÐ³Ð¾ ÑÐ¸ÑÐ»Ð° ÑÐ´ÐµÑ Ñ Acf1(7)-Ð¼ÑÑÐ°Ð½ÑÐ¾Ð² Ð¿Ð¾ÑÐ»Ðµ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð¸Ð¾Ð½Ð¸Ð·Ð¸ÑÑÑÑÐµÐ³Ð¾ Ð¸Ð·Ð»ÑÑÐµÐ½Ð¸Ñ ÑÐºÐ°Ð·ÑÐ²Ð°ÐµÑ Ð½Ð° ÑÑÐ°ÑÑÐ¸Ðµ ÐÐ¢Ð¤-Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾Ð³Ð¾ ÑÑÐ¾Ð¼Ð°ÑÐ¸Ð½-Ð°ÑÑÐµÐ¼Ð±Ð»Ð¸ÑÑÑÑÐµÐ³Ð¾ ÑÐ°ÐºÑÐ¾ÑÐ° ACF Ð² ÑÐµÐ¿Ð°ÑÐ°ÑÐ¸Ð¸ Ð¿Ð¾Ð²ÑÐµÐ¶Ð´ÐµÐ½Ð¸Ð¹ ÐÐÐ Ð½Ð° ÑÑÐ°Ð´Ð¸Ð¸ Ð´ÐµÐ»ÐµÐ½Ð¸Ð¹ Ð´ÑÐ¾Ð±Ð»ÐµÐ½Ð¸Ñ.
description: The role of ATP-dependent chromatin assembly factors in the currently poorly understood. One of the factors, which may participate in the assembly of chromatin, is a factor ACF. The aim of the work was to study the effect of mutations in the gene Acf1 subunit of ATP-dependent chromatin factor ACF assembly on the effects caused by the action of ionizing radiation in the early Drosophila embryogenesis. Using the method of scanning confocal microscope estimated duration of S-phase of the cell cycle, the total duration of the cell cycle at the early stage of embryogenesis in Drosophila embryos of wild-type strains and mutants of the gene Acf1. Also obtained data on the death of somatic nuclei of Drosophila embryos of wild-type strains and mutants by gene Acf1. These data suggest shortening S-phase of the cell cycle in the mutant gene Acf1, compared to the wild-type line, without the influence of external factors, DNA damage after exposure to ionizing radiation. The death of a greater number of cores in Acf1 (7) mutants after exposure to ionizing radiation indicates a part of ATP-dependent chromatin-assembled ACF factor in the repair of DNA damage at the stage of cleavage divisions.