Associations between serum electrolyte and short-term outcomes in patients with acute decompensated heart failure
Creators: name: Zhao, Kai
name: Zheng, Qun
name: Zhou, Jiang
name: Zhang, Qi
name: Gao, Xiaoli
name: Liu, Yinghua
name: Li, Senlin
name: Shan, Weichao
name: Liu, Li
name: Guo, Nan
name: Tian, Hongsen
name: Wei, Qingmin
name: Hu, Xitian
name: Cui, Yingkai
name: Geng, Xue
name: Wang, Qian
name: Cui, Wei
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Hematology

description: There is a dearth of comprehensive studies on the association between serum electrolyte and adverse short-term prognosis of Chinese patients with acute decompensated heart failure (ADHF). A total of 5166 patients with ADHF were divided into four serum electrolyte-related study populations (potassium (<i>n</i> = 5145), sodium (<i>n</i> = 5135), chloride (<i>n</i> = 4966), serum total calcium (STC) (<i>n</i> = 4143)) under corresponding exclusions. Different logistic regression models were utilized to gauge the association between these electrolytes or the number of electrolyte abnormalities and the risk of a composite of all-cause mortality or 30-day heart failure (HF) readmission. In multivariable adjusted analysis, patients with potassium below 3.5 mmol/L (odds ratios (ORs) 1.45; 95% confidence interval (CI):1.07–1.95), 4.01–4.50 mmol/L (OR: 1.29, CI: 1.02–1.62), 4.51–5.00 mmol/L (OR: 1.43, CI: 1.08–1.90) and above 5.00 mmol/L (OR: 1.74, CI: 1.21–2.51) had an increased risk of outcome when compared with potassium at 3.50–4.00 mmol/L. Sodium levels were inversely related to the risk of a composite outcome (&lt;130 mmol/L: OR: 2.73 (95% CI, 1.81–4.12); 130–134 mmol/L: OR, 1.97 (CI, 1.45–2.68); 135–140 mmol/L: OR, 1.45 (CI, 1.17–1.81); <i>p</i> for trend &lt; 0.001) in comparison with sodium at 141–145 mmol/L. Chloride &lt; 95 mmol/L corresponded to a higher risk of a composite outcome with an OR of 1.65 (95% CI, 1.16–2.37) in contrast to chloride levels at 101–105 mmol/L. In addition, the adjusted ORs (95% CI) for a composite outcome comparing the STC &lt; 2.00 and 2.00–2.24 vs. 2.25–2.58 mmol/L were 0.98 (0.69–1.43) and 1.13 (0.89–1.44), respectively. Besides that, the number of electrolyte abnormalities was positively related to the risk of a composite outcome (<i>N</i> = 1, OR 1.40, 95% CI: 1.13–1.73; <i>N</i> = 2, OR 2.51, 95% CI: 1.85–3.42; <i>N</i> = 3, OR 2.47, 95% CI: 1.45–4.19; <i>p</i> for trend &lt; 0.001) in comparison with <i>N</i> = 0. A deviation of potassium levels from 3.50 to 4.00 mmol/L, lower sodium levels and hypochloremia were associated with poorer short-term prognosis of ADHF. Furthermore, the number of electrolyte abnormalities positively correlated with adverse short-term prognosis of patients with ADHF. Key MessagesADHF patients with baseline serum potassium at first half part of normal range (3.50–4.00 mmol/L) may herald the lowest risk of recent cardiovascular events.Serum sodium and chloride levels exhibit discrepancies in terms of risk of short-term adverse events of ADHF patients.The number of electrolyte abnormalities is a significant predictor of poor short-term prognosis in patients with ADHF. ADHF patients with baseline serum potassium at first half part of normal range (3.50–4.00 mmol/L) may herald the lowest risk of recent cardiovascular events. Serum sodium and chloride levels exhibit discrepancies in terms of risk of short-term adverse events of ADHF patients. The number of electrolyte abnormalities is a significant predictor of poor short-term prognosis in patients with ADHF. http://www.chictr.org.cn/showproj.aspx?proj=23139. Unique identifier: ChiCTR-POC-17014020.