cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The IR-resummed Effective Field Theory of Large Scale Structures
Creators: name: Senatore, Leonardo
name: Zaldarriaga, Matias
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We present a new method to resum the effect of large scale motions in the Effective Field Theory of Large Scale Structures. Because the linear power spectrum in $Λ$CDM is not scale free the effects of the large scale flows are enhanced. Although previous EFT calculations of the equal-time density power spectrum at one and two loops showed a remarkable agreement with numerical results, they also showed a 2% residual which appeared related to the BAO oscillations. We show that this was indeed the case, explain the physical origin and show how a Lagrangian based calculation removes this differences. We propose a simple method to upgrade existing Eulerian calculations to effectively make them Lagrangian and compare the new results with existing fits to numerical simulations. Our new two-loop results agrees with numerical results up to $k\sim 0.6 h/$Mpc to within 1% with no oscillatory residuals. We also compute power spectra involving momentum which is significantly more affected by the large scale flows. We show how keeping track of these velocities significantly enhances the UV reach of the momentum power spectrum in addition to removing the BAO related residuals. We compute predictions for the real space correlation function around the BAO scale and investigate its sensitivity to the EFT parameters and the details of the resummation technique.
description: 37 pages, 9 figures. v2: JCAP published version, added references and extended explanations
Tumor necrosis factor mediates endotoxic effects in mice
Creators: name: Bauss, F.
name: Dröge, W.
name: Männel, Daniela N.
Publisher: name: Universität Regensburg
Year: 1987
Subjects: subject: 610 Medizin
subject: Animals
subject: Blood Cell Count
subject: Blood Glucose/metabolism
subject: Body Temperature Regulation/drug effects
subject: Endotoxins/toxicity
subject: Glycoproteins/toxicity
subject: Hematocrit
subject: Lactates/blood
subject: Lipopolysaccharides/toxicity
subject: Male
subject: Mice
subject: Mice, Inbred C3H
subject: Salmonella
subject: Tumor Necrosis Factor-alpha

description: Endotoxic reactions induced in mice by recombinant human tumor necrosis factor (TNF) were examined. Mice showed a dose-dependent hypothermia after intravenous TNF injection which was similar to a reaction to lipopolysaccharide injection. Plasma glucose levels were decreased, and plasma lactate levels were increased. Blood hematocrit levels were increased after TNF injection. No interleukin-1 activity was detected in the plasma of TNF-treated animals. The number of leukocytes was reduced 30 min after TNF injection and returned to normal within 24 h. Thus, the data demonstrate that the pathophysiological effects induced by TNF were similar to the effects induced by bacterial endotoxin. Since lipopolysaccharide is a very potent agent for eliciting TNF release from activated macrophages, these results suggest that TNF could act as an endogenous mediator of endotoxin effects.
Proteomics Approach COPD Fibroblasts - Online Supplemental Data
Creators: name: Bekker, Nicolaas J.
name: van Pijkeren, Alienke
name: Wolters, Justina C.
name: Sánchez Brotons, Alejandro
name: Guryev, Victor
name: Woldhuis, Roy
name: Bischoff, Rainer
name: Alkema, Wynand
name: van den Berge, Maarten
name: Horvatovich, Peter
name: Van Nijnatten, Jos
name: Timens, Wim
name: Brandsma, Corry-Anke
Publisher: name: figshare
Year: 2023
Subjects: Respiratory diseases
Pathology (excl. oral pathology)
Oral medicine and pathology
Plant cell and molecular biology
Animal cell and molecular biology
Gene expression (incl. microarray and other genome-wide approaches)
Biochemistry and cell biology not elsewhere classified
Epidemiology not elsewhere classified
Medical biochemistry - proteins and peptides (incl. medical proteomics)
Proteomics and intermolecular interactions (excl. medical proteomics)

description: Supplemental figures and tables for the research article "A proteomics approach to identify COPD-related changes in lung fibroblasts" by N.J. Bekker et al.
Very large thermophase in ferromagnetic Josephson junctions
Creators: name: Giazotto, F.
name: Heikkilä, T. T.
name: Bergeret, F. S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: The concept of thermophase refers to the appearance of a phase gradient inside a superconductor originating from the presence of an applied temperature bias across it. The resulting supercurrent flow may, in suitable conditions, fully counterbalance the temperature-bias-induced quasiparticle current therefore preventing the formation of any voltage drop, i.e., a thermovoltage, across the superconductor. Yet, the appearance of a thermophase is expected to occur in Josephson-coupled superconductors as well. Here we theoretically investigate the thermoelectric response of a thermally-biased Josephson junction based on a ferromagnetic insulator. In particular, we predict the occurrence of a very large thermophase which can reach $π/2$ across the contact for suitable temperatures and structure parameters, i.e., the quasiparticle thermal current can reach the critical current. Such a thermophase can be several orders of magnitude larger than that predicted to occur in conventional Josephson tunnel junctions. In order to assess experimentally the predicted very large thermophase we propose a realistic setup realizable with state-of-the-art nano fabrication techniques and well-established materials which is based on a superconducting quantum interference device. This effect could be of strong relevance in several low-temperature applications, for example, for revealing tiny temperature differences generated by coupling the electromagnetic radiation to one of the superconductors forming the junction.
description: 4.5 pages, 4 color figures
Reversing The Weapons: Recuperating the marginalised body with performative photography
Creators: name: Morris-cafiero, Haley
Publisher: name: University of Westminster
Year: 2023

description: This thesis investigates the practice-based research connected with three photographic series produced over twelve years. Wait Watchers, The Bully Pulpit, and Buoyant Force have been exhibited in multiple solo and group exhibitions internationally and have been the subject of viral media activity and two monographs. The practice contributes to the discussions of performance, collaboration, and transgressive humour in photography. Supporting research involves theoretical discourses around the gaze, the invisibility of marginalised bodies, and social media as the 21st century panopticon. The work activates the disobedient female body defined as “grotesque” through wilful transgressions of the rules that try to control it. Performative self-portrait photography is employed to show the evolution of a marginalised body, first operating as the site of public attack, then as a figure with agency to enact revenge on Internet trolls and finally acting as a body empowered through performance. This thesis analyses the three photographic series in relation to the following research questions: How can performative photographic methods be used to challenge Western society’s standards of beauty that regulate the idealised shape of the female body? How can photography bring into visibility Western society’s use of the gaze and humour as devices to maintain patriarchal female body standards? How can collaborative photographic methods be used to empower marginalised bodies and bring them into visibility in previously unimagined ways? These questions are addressed in relation to these photographic series over six sections examining art historical, photographic, feminist, and sociological frameworks. Section 1 establishes the framework that positions my body as marginalised within society’s Western standards of idealised female beauty. Section 2 employs the writings of Mikhail Bakhtin and Mary Russo to figure and celebrate my body that is the subject of this practice-based research as grotesque. Section 3 asserts a definition of performative photography within the practicebased research as a methodology based on the scholarship of Amelia Jones, Michel Poivert, and Philip Auslander. Section 4 employs the writings of Michel Foucault and Jeannine A. Gailey to examine the marginalised female body as a site for social attack through the gaze as evidenced in Wait Watchers and bullying comments received through social media. Section 5 examines The Bully Pulpit in relation to theories of public shaming and the use of humour as a device for social control. Section 6 concludes this thesis by analysing Buoyant Force’s contribution to collaborative photography, tracing the development of performances and costumes produced in dialogue with collaborators who were inspired by Wait Watchers.
Enumeration of $k$-Fibonacci Paths using Infinite Weighted Automata
Creators: name: De Castro, Rodrigo
name: Ramírez, José L.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 52B05, 11B39, 05A15

description: In this paper, we introduce a new family of generalized colored Motzkin paths, where horizontal steps are colored by means of $F_{k,l}$ colors, where $F_{k,l}$ is the $l$th $k$-Fibonacci number. We study the enumeration of this family according to the length. For this, we use infinite weighted automata.
description: arXiv admin note: substantial text overlap with arXiv:1310.2449
Biological aspects of tumor necrosis factor
Creators: name: Männel, Daniela N.
Publisher: name: Universität Regensburg
Year: 1986
Subjects: subject: 610 Medizin
subject: Animals
subject: Body Temperature/drug effects
subject: Cell Survival/drug effects
subject: Cells, Cultured
subject: Endotoxins/toxicity
subject: Female
subject: Glycoproteins/pharmacology
subject: Interferon-gamma/pharmacology
subject: Macrophage Activation
subject: Macrophages/physiology
subject: Male
subject: Mice
subject: Neoplasms, Experimental/therapy
subject: Recombinant Proteins/pharmacology
subject: Tumor Necrosis Factor-alpha

description: Tumor necrosis factor (TNF) has been determined as an endogenous mediator for endotoxin-induced tumor necrosis. This macrophage product has been biochemically characterized and its protein structure defined by molecular cloning of the TNF gene. Experiments with antibodies to TNF demonstrated that TNF acts as an effector molecule of activated cytotoxic macrophages involved in tumor destruction. Purified TNF has been shown to exert direct necrotic activity against tumors in vivo. In addition, a number of similar effects in vivo and in vitro of TNF, endotoxin, and interleukin 1 (IL 1) have been observed. For example, in vivo the thermoregulatory activity of TNF is similar to IL 1. Since TNF was found to mediate other effects of endotoxin in modulating immune responses in addition to the tumor necrotic activity, it can be considered a true immunoregulator produced by macrophages after endotoxin stimulation.
Decrease of natural killer cell activity and monokine production in peripheral blood of patients treated with recombinant tumor necrosis factor
Creators: name: Kist, A.
name: Ho, A. D.
name: Räth, U.
name: Wiedenmann, B.
name: Bauer, A.
name: Schlick, E.
name: Kirchner, H.
name: Männel, Daniela N.
Publisher: name: Universität Regensburg
Year: 1988
Subjects: subject: 610 Medizin
subject: Adult
subject: Concanavalin A
subject: Cytotoxicity, Immunologic/drug effects
subject: Drug Evaluation
subject: Female
subject: Humans
subject: Immunosuppressive Agents/administration & dosage
subject: Infusions, Intravenous
subject: Interleukin-1/biosynthesis
subject: Killer Cells, Natural/immunology
subject: Lymphocyte Activation/drug effects
subject: Male
subject: Middle Aged
subject: Neoplasms/immunology
subject: Phytohemagglutinins
subject: Receptors, Fc/analysis
subject: Receptors, IgG
subject: Recombinant Proteins/administration & dosage
subject: Tumor Necrosis Factor-alpha/administration & dosage

description: Tumor necrosis factor (TNF), a protein predominantly produced by activated macrophages/monocytes, is presently available in recombinant, purified form for clinical trials. Intensive studies in many laboratories have shown that besides the tumorcytotoxic effects, TNF acts on a large array of different cells and has potent immunomodulatory activities. In a clinical phase I study, some immunologic functional parameters of blood cells from patients who received 24-hour infusions of recombinant human TNF (rhTNF) were analyzed. Natural killer (NK) cell activity, TNF production, interleukin-1 (IL-1) production and mitogen-induced proliferation were measured either in whole blood samples or in cultures of peripheral mononuclear leukocytes of the patients directly before and after rhTNF infusion. NK cell activity, TNF and IL-1 production capacity and proliferative responses to concanavalin A (Con A) were significantly reduced after rhTNF application. We conclude from these observations that rhTNF in vivo acts directly or indirectly on NK cells and monocytes by either inactivating their functional capacity or by absorbing the relevant cells to the endothelial cell layer, thus removing them from circulation.
Protein-protein interactions and novel biomarkers of Leiomyosarcoma
Creators: name: ashraf, farinaz
name: Jafarpoorian, Amirhossein
name: Silverman, Rosalind
name: Silverman, Lorelei
Publisher: name: figshare
Year: 2022
Subjects: Molecular targets
Predictive and prognostic markers
Cancer cell biology

description: Soft-tissue sarcoma (STS) arises mainly from the embryonic mesoderm with some contribution from the neuroectoderm. STS is a rare malignancy that accounts for less than 1% of all adult cancers. It encompasses a heterogeneous group of tumours with over 175 molecular subtypes. Classically, LMS would either originate directly from the smooth muscle cells or from the precursor mesenchymal stem cells that would eventually differentiate into smooth muscle cells. (1) The rarity of this disease has led to various problems in research, diagnosis and providing acceptable therapeutic options. As such the new biomarkers would give experts new perspectives for treating this disease
Spectroscopy of Surface-Induced Noise Using Shallow Spins in Diamond
Creators: name: Romach, Y.
name: Muller, C.
name: Unden, T.
name: Rogers, L. J.
name: Isoda, T.
name: Itoh, K. M.
name: Markham, M.
name: Stacey, A.
name: Meijer, J.
name: Pezzagna, S.
name: Naydenov, B.
name: McGuinness, L. P.
name: Bar-Gill, N.
name: Jelezko, F.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We report on the noise spectrum experienced by few nanometer deep nitrogen-vacancy centers in diamond as a function of depth, surface coating, magnetic field and temperature. Analysis reveals a double-Lorentzian noise spectra consistent with a surface electronic spin bath, with slower dynamics due to spin-spin interactions and faster dynamics related to phononic coupling. These results shed new light on the mechanisms responsible for surface noise affecting shallow spins at semiconductor interfaces, and suggests possible directions for further studies. We demonstrate dynamical decoupling from the surface noise, paving the way to applications ranging from nanoscale NMR to quantum networks.
Tumour necrosis factor production and natural killer cell activity in peripheral blood during treatment with recombinant tumour necrosis factor
Creators: name: Männel, Daniela N.
name: Kist, A.
name: Ho, A. D.
name: Räth, U.
name: Reichardt, P.
name: Wiedenmann, B.
name: Schlick, E.
name: Kirchner, H.
Publisher: name: Universität Regensburg
Year: 1989
Subjects: subject: 610 Medizin
subject: Adult
subject: Aged
subject: Colorectal Neoplasms/therapy
subject: Female
subject: Humans
subject: Killer Cells, Natural/drug effects
subject: Male
subject: Middle Aged
subject: Recombinant Proteins/therapeutic use
subject: Tumor Necrosis Factor-alpha/therapeutic use

description: Tumour necrosis factor (TNF) has been found to be an important immunomodulator. Among other functions TNF activates natural killer (NK) cells and stimulates monocytes/macrophages in an autocrine fashion. TNF production and NK activity in peripheral blood mononuclear cells were determined in a clinical phase I study in which recombinant human (rh) TNF was administered as a continuous infusion weekly for a period of 8 weeks. Even though TNF production and NK activity were significantly reduced directly after rhTNF infusion the effect proved to be transient and most pronounced at the first rhTNF administration. One day after completion of the rhTNF infusion the peripheral cells released more TNF into the supernatant compared to TNF activity immediately before the rhTNF infusion. This effect was conspicuous in non-stimulated cultures. After repeated rhTNF infusions both stimulated and non-stimulated TNF production of the peripheral blood mononuclear cells was increased. NK cell activity was also enhanced after repeated cycles of rhTNF administration as compared to early rhTNF treatment. Thus, repeated rhTNF infusions lead to a stimulatory effect on TNF production and NK activity of peripheral blood cells.
Probing fluctuations and correlations of strangeness by net-kaon cumulants in Au+Au collisions at $\sqrt{s_{NN}} = 7.7$ GeV
Creators: name: Chen, Qian
name: Wang, Han-Sheng
name: Ma, Guo-Liang
Publisher: name: arXiv
Year: 2022
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We calculate the cumulants and correlation functions of net-kaon multiplicity distributions in Au+Au collisions at $\sqrt{s_{NN}} = 7.7$ GeV using a multiphase transport model (AMPT) with both a new coalescence mechanism and all charge conservation laws. The AMPT model can qualitatively describe the centrality dependences of the net-kaon cumulants and cumulant ratios measured by the STAR experiment. By focusing on the stage evolution of the cumulants, cumulant ratios, and correlation functions, we reveal several key effects on the fluctuations and correlations of strangeness during the dynamical evolution of relativistic heavy-ion collisions, including strangeness production and diffusion, hadronization, hadronic rescatterings, and weak decays. Without considering the quantum chromodynamics critical fluctuations in the dynamic model, we demonstrate that the net-kaon fluctuations can largely represent the net-strangeness fluctuations. Our results provide a baseline for understanding the net-kaon and net-strangeness fluctuations, which help to search for the possible critical behaviors at the critical end point in relativistic heavy-ion collisions.
description: 11 pages, 7 figures; final published version
Bootstrap percolation in inhomogeneous random graphs
Creators: name: Amini, Hamed
name: Fountoulakis, Nikolaos
name: Panagiotou, Konstantinos
Publisher: name: arXiv
Year: 2014
Subjects: subject: Probability (math.PR)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05C80, 60K35

description: A bootstrap percolation process on a graph G is an "infection" process which evolves in rounds. Initially, there is a subset of infected nodes and in each subsequent round every uninfected node which has at least r infected neighbours becomes infected and remains so forever. The parameter r > 1 is fixed. We consider this process in the case where the underlying graph is an inhomogeneous random graph whose kernel is of rank 1. Assuming that initially every vertex is infected independently with probability p > 0, we provide a law of large numbers for the number of vertices that will have been infected by the end of the process. We also focus on a special case of such random graphs which exhibit a power-law degree distribution with exponent in (2,3). The first two authors have shown the existence of a critical function a_c(n) such that a_c(n)=o(n) with the following property. Let n be the number of vertices of the underlying random graph and let a(n) be the number of the vertices that are initially infected. Assume that a set of a(n) vertices is chosen randomly and becomes externally infected. If a(n) << a_c(n), then the process does not evolve at all, with high probability as n grows, whereas if a(n)>> a_c(n), then with high probability the final set of infected vertices is linear. Using the techniques of the previous theorem, we give the precise asymptotic fraction of vertices which will be eventually infected when a(n) >> a_c (n) but a(n) = o(n). Note that this corresponds to the case where p approaches 0.
description: 42 pages
Finite size correction to the spectrum of regular random graphs: an analytical solution
Creators: name: Metz, Fernando L.
name: Parisi, Giorgio
name: Leuzzi, Luca
Publisher: name: arXiv
Year: 2014
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Probability (math.PR)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We develop a thorough analytical study of the $O(1/N)$ correction to the spectrum of regular random graphs with $N \rightarrow \infty$ nodes. The finite size fluctuations of the resolvent are given in terms of a weighted series over the contributions coming from loops of all possible lengths, from which we obtain the isolated eigenvalue as well as an analytical expression for the $O(1/N)$ correction to the continuous part of the spectrum. The comparison between this analytical formula and direct diagonalization results exhibits an excellent agreement, confirming the correctness of our expression.
description: Extended version with an extra appendix explaining the connection with rigorous results
Induction of monokine production by tumor cells
Creators: name: Männel, Daniela N.
name: Jänicke, R.
Publisher: name: Universität Regensburg
Year: 1989
Subjects: subject: 610 Medizin
subject: Biological Factors/metabolism
subject: Humans
subject: Interleukin-1/genetics
subject: Monocytes/metabolism
subject: Monokines
subject: RNA, Messenger/metabolism
subject: Tumor Cells, Cultured/immunology
subject: Tumor Necrosis Factor-alpha/genetics

description: Cells of the proerythromyeloid cell line K562 and of the T cell line Jurkat were able to induce an increase in TNF-, IL1 alpha-, and IL1 beta-mRNA expression in human peripheral blood derived monocytes in vitro. The activating principle of these tumor cells was associated with fractions of membrane preparations of distinct molecular mass, 32-38 kD for Jurkat cells and 46-54 kD for K562 cells, respectively. At least part of the activating constituent seemed to be protein in nature. Isolated membrane preparations of both cell types induced production and secretion of TNF. Stimulation of monocytes with the viable tumor cells led to TNF release only when Jurkat cells were used. Viable K562 cells induced enhanced TNFmRNA expression but seemed to absorb soluble TNF from the supernatant.
Excited-state quantum phase transitions and periodic dynamics
Creators: name: Engelhardt, G.
name: Bastidas, V. M.
name: Kopylov, W.
name: Brandes, T.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We investigate signatures of the excited-state quantum phase transition in the periodic dynamics of the Lipkin-Meshkov-Glick model and the Tavis-Cummings model. In the thermodynamic limit, expectation values of observables in eigenstates of the system can be calculated using classical trajectories. Motivated by this, we suggest a method based on the time evolution of the finite-size system, to find singularities in observables, which arise due to the excited-state quantum phase transition.
description: 9 pages, 3 figures, comments are welcome
Spontaneous monokine release by alveolar macrophages in chronic sarcoidosis
Creators: name: Strausz, J.
name: Männel, Daniela N.
name: Pfeifer, S.
name: Borkowski, A.
name: Ferlinz, R.
name: Müller-Quernheim, J.
Publisher: name: Universität Regensburg
Year: 1991
Subjects: subject: 610 Medizin
subject: Adult
subject: Antibodies, Monoclonal/immunology
subject: Bronchoalveolar Lavage Fluid/immunology
subject: CD4-CD8 Ratio
subject: Chronic Disease
subject: Female
subject: Humans
subject: Interleukin-1/biosynthesis
subject: Lung Diseases/immunology
subject: Lymphocyte Activation/immunology
subject: Macrophages, Alveolar/immunology
subject: Male
subject: Sarcoidosis/immunology
subject: T-Lymphocytes/immunology
subject: Tumor Necrosis Factor-alpha/biosynthesis

description: In pulmonary sarcoidosis an activation of alveolar T lymphocytes and alveolar macrophages (AM) has been demonstrated. There is evidence that in contrast to acute disease a heightened T-cell response cannot be observed in the chronic phase of sarcoidosis. The role of AM in the inflammatory process of chronic sarcoidosis is not yet intensively evaluated. To address this question we measured the release of tumor necrosis factor alpha (TNF alpha) and interleukin-1 (IL-1) by AM of 39 patients with chronic sarcoidosis (duration greater than 4 years; 30 active, 9 inactive diseases) without therapy and correlated the monokine release with parameters of T-cell alveolitis and the course of the disease. The T4/T8 ratio was higher in the active than in the inactive group without reaching statistical significance. TNF alpha as well as IL-1 is spontaneously released by AM of the active group 2,099 +/- 518 pg/ml TNF alpha/10(6) cells/24 h and 8/13 (IL-1+/total) respectively. In the inactive group the AM release 375 +/- 246 pg/ml TNF alpha/10(6) cells/24 h which is in the range of the control and 1 out of 5 patients was IL-1-positive. There was no correlation between the monokine release and any parameter of T-cell alveolitis. These data support the hypothesis that the inflammatory process in chronic sarcoidosis is dominated by the activity of AM and that this activity determines the course of the disease.
Distinct tumor cell membrane constituents activate human monocytes for tumor necrosis factor synthesis
Creators: name: Jänicke, R.
name: Männel, Daniela N.
Publisher: name: Universität Regensburg
Year: 1990
Subjects: subject: 610 Medizin
subject: Blotting, Northern
subject: Gene Expression Regulation
subject: Humans
subject: Lipopolysaccharides/pharmacology
subject: Macrophage Activation
subject: Membrane Proteins/physiology
subject: Monocytes/metabolism
subject: Neoplasm Proteins/physiology
subject: Neoplasms/physiopathology
subject: RNA, Messenger/genetics
subject: Tumor Cells, Cultured
subject: Tumor Necrosis Factor-alpha/biosynthesis

description: Several lines of evidence point to an activation mechanism of monocytes/macrophages by tumor cells. In this study we present data for distinct surface structures on K562 and Jurkat cells to directly induce TNF-mRNA expression and TNF production by human peripheral blood monocytes. Northern analysis showed that incubation of monocytes with either K562 or Jurkat cells led to a significant increase in TNF-mRNA expression. In addition, enhanced TNF production was detected in supernatants of monocyte cultures activated by Jurkat cells. Not only viable tumor cells but also metabolically inactivated tumor cells, cytoblasts, and membrane preparations from Jurkat and K562 cells induced TNF-mRNA expression. We identified two different membrane protein fractions with relative molecular mass of 32 to 38 kDa for Jurkat cells and 46 to 54 kDa for K562 cells that were responsible for monocyte activation.
YKS TERCİHLERİNDE VERİ MADENCİLİĞİ VE YAPAY ZEKA UYGULAMALARI
Creators: name: Kaya, Rıdvan
Publisher: name: Zenodo
Year: 2024

description: Yks tercihlerinin bilimsel bir şekilde yapılabilmesi için veri madenciliği, istatistik, matematik, yazılım ve yapay zekadan faydalanmak gerekir.  Bu kitapçıkla birlikte bunu nasıl yapacağınızı öğreneceksiniz.
Taylor- and fugacity expansion for the effective Z(3) spin model of QCD at finite density
Creators: name: Grünwald, Eva
name: Mercado, Ydalia Delgado
name: Gattringer, Christof
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Series expansions in the chemical potential mu are studied for an effective theory of QCD which has a flux representation where the complex action is overcome. In particular we consider fugacity series, Taylor expansion and a modified Taylor expansion and compare the outcome of these series to the reference results from a Monte Carlo simulation in the flux representation where arbitrary mu is accessible. It is shown that for most parameter values the fugacity expansion gives the best approximation to the data from the flux simulation, followed by our newly proposed modified Taylor expansion. For the conventional Taylor expansion we find that the results coincide with the flux data only for very small mu.
description: Minor changes. Final version to appear in International Journal of Modern Physics A
Supplementary Information from Pathogen transmission modes determine contact network structure, altering other pathogen characteristics
Creators: name: Collier, Melissa
name: Albery, Gregory F.
name: McDonald, Grant C.
name: Bansal, Shweta
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 60801 Animal Behaviour

description: Additional results and figures to add context to the main document
ASSESSMENT OF PHARMACEUTICAL INVENTORY MANAGEMENT PERFORMANCE AT HEALTH FACILITIES
Creators: name: Tariku Mahammed
Publisher: name: Zenodo
Year: 2018

description: The purpose of this study was to assess the pharmaceutical inventory management performance

at health facilities found in South Wollo zone, Amhara region. The specific objective of the study

are to measure how accurate is the stock-keeping records, to determine the significance of the

record-keeping errors, to find out how much of the pharmaceutical stock is maintained, to

determine the average stock out duration of pharmaceuticals, to identify the pharmaceutical

storage conditions in health facilities of South Wollo zone. The study was a cross-sectional survey

that involved nine health facilities of south Wollo zone, Amhara region. The research adopted

descriptive study design. A stratified random sampling technique was applied to the study. The

researcher used a sample size of 30% of the target population to act as the sample size. The

researcher used inventory management assessment tool and storage condition observation

checklist to collect data for the research. The collected data were quantitatively analyzed using

statistical methods to produce frequency tables and graphs for effective interpretation. The key

findings from the study revealed that all health facilities visited had stock out of a number of tracer

products in the past 100 days. The study found that the average percent of time out of stock was

14%, the average percent of products available on the day of assessment was 76% in the surveyed

public health facilities found in South Wollo Zone, The study has found that the average percentage

of stock keeping records that were accurate is 62%, health facilities had on average 27% of

records greater than physical counts, health facilities had on average 12% of records were lesser

than physical counts and the average ratio of inventory variation to total stock is 11%. The study

also revealed that majority of the public health facilities (55.6%) practiced unacceptable storage

condition. This study demonstrated poor inventory management with respect to the general quality

of record keeping, space allocation and general organization of the pharmaceutical storeroom.
Differentiability Properties for Boundary Control of Fluid-Structure Interactions of Linear Elasticity with Navier-Stokes Equations with Mixed-Boundary Conditions in a Channel
Creators: name: Hintermüller, Michael
name: Kröner, Axel
Publisher: name: New York, NY : Springer
Year: 2023
Subjects: subject: Boundary control
subject: Differentiability properties
subject: Domain with corners
subject: Fluid-structure interaction
subject: Mixed boundary conditions
subject: Navier Stokes equation
subject: 510

description: In this paper we consider a fluid-structure interaction problem given by the steady Navier Stokes equations coupled with linear elasticity taken from (Lasiecka et al. in Nonlinear Anal 44:54–85, 2018). An elastic body surrounded by a liquid in a rectangular domain is deformed by the flow which can be controlled by the Dirichlet boundary condition at the inlet. On the walls along the channel homogeneous Dirichlet boundary conditions and on the outflow boundary do-nothing conditions are prescribed. We recall existence results for the nonlinear system from that reference and analyze the control to state mapping generalizing the results of (Wollner and Wick in J Math Fluid Mech 21:34, 2019) to the setting of the nonlinear Navier-Stokes equation for the fluid and the situation of mixed boundary conditions in a domain with corners.
The impact of financial development on labour share: a cross country study
Creators: name: Vijayasivajie, Anushiya
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Our study investigates the impact of financial development on functional income inequality. Unlike financial development and personal income inequality, this nexus has received little interest. But this nexus is equally important and requires serious exposition given the close association between personal and functional income inequality and the much documented global post 1980s increase in functional income inequality—this as revealed by trends of declining labour share. To investigate this nexus, our study utilises a heterogenous set of mostly high and middle income countries and implements static as well as dynamic models; moreover, the study also includes a selection of factors studied in the past, technological progress, globalisation etc. as controls, and redresses issues of labour share underestimation by utilising labour share measures that include the income of the self-employed. On our main result, it underscores that, in high income countries, financial development reduces functional income inequality whilst, in middle income countries, its impact is unclear. This finding is robust (to some extent) to different measures of financial development and labour share, as well as, to static and dynamic specifications. Hence, our results stress that loosening regulations on credit intermediation and developing incentives that boosts savings and lending in the economy has short and medium run positive impact on countering increasing functional income inequality in most countries. On the other variables, our results suggest that, they also tend to impact countries differently. On technological progress, our results strongly suggest that, in high income countries, capital augmenting technological progress increases functional income inequality, though greater government economic involvement redresses this. In contrast, in middle income countries, financial globalisation increases functional income inequality, though, educational development reverses this.
Inhibition of endotoxin-induced activation of human monocytes by human lipoproteins
Creators: name: Flegel, W. A.
name: Wölpl, A.
name: Männel, Daniela N.
name: Northoff, H.
Publisher: name: Universität Regensburg
Year: 1989
Subjects: subject: 610 Medizin
subject: Antibodies, Bacterial/physiology
subject: Cholesterol/blood
subject: Complement System Proteins/physiology
subject: Dietary Fats/blood
subject: Endotoxins
subject: Fatty Acids/blood
subject: Humans
subject: Immunosuppressive Agents/physiology
subject: Kinetics
subject: Lipopolysaccharides/immunology
subject: Lipoproteins/physiology
subject: Macrophage Activation
subject: Temperature

description: Toxicity of lipopolysaccharide (LPS) (endotoxin) is, to a large extent, mediated by the activation of monocytes/macrophages and subsequent release of monokines, such as interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-alpha). It is known that LPS binds readily to serum lipoproteins and that LPS-lipoprotein complexes are less toxic than unbound LPS. Here we present data analyzing the impact of the LPS-serum interaction at the cellular level. By measuring IL-1 TNF-alpha, and IL-6, the interaction of different LPSs or lipid A with human serum could be shown to prevent the activation of human monocytes. The amounts of LPS inactivated by normal human serum did not exceed 10 ng/ml. The LPS-inactivating capacity of serum was shown to be a function of the lipoproteins. Other serum components, such as naturally occurring anti-LPS immunoglobulin G, complement, or nutritive lipids, had no significant influence in our system. Our experiments suggest that serum lipoproteins control endotoxin-induced monocyte activation and monokine release.
Disordered structures in ultracold spin-imbalanced Fermi gas
Creators: name: Tüzemen, Buğra
name: Zawiślak, Tomasz
name: Wlazłowski, Gabriel
name: Magierski, Piotr
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We investigate properties of spin-imbalanced ultracold Fermi gas in a large range of spin polarizations at low temperatures. We present results of microscopic calculations based on mean-field and density functional theory approaches, with no symmetry constraints. At low polarization values we predict the structure of the system as consisting of several spin-polarized droplets. As the polarization increases, the system self-organizes into a disordered structures similar to liquid crystals, and energetically they can compete with ordered structures such as grid-like domain walls. At higher polarizations the system starts to develop regularities that, in principle, can be called supersolid, where periodic density modulation and pairing correlations coexist. The robustness of the results has been checked with respect to temperature effects, dimensionality, and the presence of a trapping potential. Dynamical stability has also been investigated.
description: Ancillary files contain reproducibility packs of numerical calculations
Simultaneous quasi-optimal convergence in FEM-BEM coupling
Creators: name: Melenk, Jens Markus
name: Praetorius, Dirk
name: Wohlmuth, Barbara
Publisher: name: arXiv
Year: 2014
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 65N30, 65N38

description: We consider the symmetric FEM-BEM coupling that connects two linear elliptic second order partial differential equations posed in a bounded domain $Ω$ and its complement, where the exterior problem is restated by an integral equation on the coupling boundary $Γ=\partialΩ$. We assume that the corresponding transmission problem admits a shift theorem for data in $H^{-1+s}$, $s \in [-1,-1+s_0]$, $s_0 > 1/2$. We analyze the discretization by piecewise polynomials of degree $k$ for the domain variable and piecewise polynomials of degree $k-1$ for the flux variable on the coupling boundary. Given sufficient regularity we show that (up to logarithmic factors) the optimal convergence $O(h^{k+1/2})$ in the $H^{-1/2}(Γ)$-norm is obtained for the flux variable, while classical arguments by Céa-type quasi-optimality and standard approximation results provide only $O(h^k)$ for the overall error in the natural product norm on $H^1(Ω)\times H^{-1/2}(Γ)$.
On the Regularity of Weak Solutions to Time-Periodic Navier–Stokes Equations in Exterior Domains
Creators: name: Eiter, Thomas
Publisher: name: Basel : MDPI
Year: 2022
Subjects: subject: exterior domain
subject: Oseen problem
subject: regularity criterion
subject: Serrin condition
subject: time-periodic solutions
subject: weak solutions
subject: 510

description: Consider the time-periodic viscous incompressible fluid flow past a body with non-zero velocity at infinity. This article gives sufficient conditions such that weak solutions to this problem are smooth. Since time-periodic solutions do not have finite kinetic energy in general, the well-known regularity results for weak solutions to the corresponding initial-value problem cannot be transferred directly. The established regularity criterion demands a certain integrability of the purely periodic part of the velocity field or its gradient, but it does not concern the time mean of these quantities.
title: Optimizing Collaborative Plain Text Editing Algorithms for Decentralized Non-Realtime Text Editing
Creators: name: Hedtke, Moritz
Publisher: name: UNSPECIFIED
Year: 2024

description: Text editing is ubiquitous, as it occurs on almost every website, mobile app, and desktop application. Collaborative text editing avoids manual synchronization when working together with others on text. This requires algorithms that can efficiently combine the concurrent edit operations in an intent-preserving way. Additionally, supporting a wide range of network scenarios enables offline work in a decentralized manner with better availability and reliability than with central servers. In this thesis, we first look at prior solutions for plain text editing and their ability to preserve user intentions, as users should not experience unexpected behavior when concurrently editing text. Then, we improve the benchmarking approach of prior research to estimate asymptotic complexity and to measure performance of algorithmic edge cases. Based on that, we propose optimizations for a prior collaborative text editing algorithm called Fugue. Our optimized algorithm can handle character insertion and deletion in logarithmic runtime in relation to the text length and with constant memory usage per character operation. It uses 25 bytes and one microsecond per operation on four Intel Xeon Gold vCPUs for a representative text with 25 million operations. We also develop a local web application as a proof of concept for working on plain text collaboratively using WebRTC. Additionally, we show that the maximally non-interleaving property in the Fugue paper can exhibit interleaving when deletions are involved.
Electromagnetic fields in compact binaries: a post-Newtonian approach
Creators: name: Henry, Quentin
name: Larrouturou, François
name: Le Poncin-Lafitte, Christophe
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2023

description: Galactic binaries, and notably double white dwarfs systems, will be a prominent source for the future LISA and Einstein Telescope detectors. Contrarily to the black holes observed by the current LIGO-Virgo-KAGRA network, such objects bear intense magnetic fields, that are naturally expected to leave some imprints on the gravitational wave emission. The purpose of this work is thus to study those imprints within the post-Newtonian (PN) framework, particularly adapted to double white dwarfs systems. To this end, we construct an effective action that takes into account the whole electromagnetic structure of a star, and then specify it to dipolar order. With this action at hand, we compute the acceleration and Noetherian quantities for generic electric and magnetic dipoles, at a relative 2PN order. Finally, focusing on physically relevant systems, we show that the magnetic effects on the orbital frequency, energy and angular momentum is significant, confirming previous works conclusions.
Numerical upscaling of parametric microstructures in a possibilistic uncertainty framework with tensor trains
Creators: name: Eigel, Martin
name: Gruhlke, Robert
name: Moser, Dieter
name: Grasedyck, Lars
Publisher: name: Heidelberg : Springer
Year: 2022
Subjects: subject: Fuzzy partial differential equations
subject: Homogenisation
subject: Linear elasticity
subject: Low-rank tensor formats
subject: Parametric partial differential equations
subject: Polymorphic uncertainty modeling
subject: Possibility
subject: Tensor trains
subject: Uncertainty quantification
subject: 530
subject: 004

description: A fuzzy arithmetic framework for the efficient possibilistic propagation of shape uncertainties based on a novel fuzzy edge detection method is introduced. The shape uncertainties stem from a blurred image that encodes the distribution of two phases in a composite material. The proposed framework employs computational homogenisation to upscale the shape uncertainty to a effective material with fuzzy material properties. For this, many samples of a linear elasticity problem have to be computed, which is significantly sped up by a highly accurate low-rank tensor surrogate. To ensure the continuity of the underlying mapping from shape parametrisation to the upscaled material behaviour, a diffeomorphism is constructed by generating an appropriate family of meshes via transformation of a reference mesh. The shape uncertainty is then propagated to measure the distance of the upscaled material to the isotropic and orthotropic material class. Finally, the fuzzy effective material is used to compute bounds for the average displacement of a non-homogenized material with uncertain star-shaped inclusion shapes.
Isoniazid protects mice against endotoxin lethality without influencing tumor necrosis factor synthesis and release
Creators: name: Urbaschek, R.
name: Männel, Daniela N.
name: Urbanczik, R.
Publisher: name: Universität Regensburg
Year: 1991
Subjects: subject: 610 Medizin
subject: Animals
subject: Cells, Cultured
subject: Endotoxins/toxicity
subject: Female
subject: Humans
subject: Isoniazid/pharmacology
subject: Mice
subject: Monocytes/metabolism
subject: RNA, Messenger/metabolism
subject: Tumor Necrosis Factor-alpha/secretion

description: Treatment of NMRI mice with isoniazid (INH; 25 mg/kg) intraperitoneally induced significant protection when it was injected before or after a lethal intravenous challenge with endotoxin. The INH preparation used was not contaminated with endotoxin. Tumor necrosis factor (TNF) was not elevated in sera from NMRI mice 2 h after the injection of INH. INH did not influence TNF synthesis or release determined in human monocytes in vitro. Therefore, it is concluded that the protective effect of INH against lethal endotoxin is not due to a suppressive effect of INH on TNF production.
Electromagnetic Cascade Emission from Neutrino-Coincident Tidal Disruption Events
Creators: name: Yuan, Chengchao
name: Winter, Walter
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2023
Subjects: neutrino, production
cosmic radiation, acceleration
cascade, electromagnetic
cascade, emission
X-ray
efficiency
GeV
time dependence

description: The potential association between Tidal Disruption Events (TDEs) and high-energy astrophysical neutrinos implies the acceleration of cosmic rays. These accelerated particles will initiate electromagnetic (EM) cascades spanning from keV to GeV energies by the processes related to neutrino production. We model the EM cascade and neutrino emissions by numerically solving the time-dependent transport equations and discuss the implications for AT2019dsg and AT2019fdr in the X-ray and $\gamma$-ray bands. We show that the $\gamma$-ray constraints from \emph{Fermi} can constrain the size of the radiation zone and the maximum energy of injected protons, and that the corresponding expected neutrino event numbers in follow-up searches are limited to be less than about 0.1. Depending on the efficiency of $p\gamma$ interactions, the X-ray and $\gamma$-ray signals can be expected closer to the peak of the optical-ultraviolet (OUV) luminosity, or to the time of the neutrino production.