cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Strukturmechanische Beanspruchungsanalysen dentaler Restaurationen unter Anwendung der Finite-Elemente-Methode
Creators: name: Joedecke, Paul
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: Finite element analysis
subject: Digital imaging techniques
subject: 3D processing
subject: Periodontal ligament
subject: 620.00151825

description: Statement of problem: The development of Finite-Element-Analysis (FEA) in dentistry has progressed rapidly since the 1970s. Nevertheless, results from this application are not used in everyday clinical practice. The effort to create an FEA is high and the validation process difficult. Much time and money must be invested in order to get adequate results. Objectives: The aim of this study was to investigate the static-structural behavior of numerical simulations in dentistry. Moreover, a deduction of the results was performed to carry out an in-silico-validation. Materials and methods: A total of four simulation models were created based on CT and μCT data as well as on an intraoral scan. To perform a simulation, the data sets were segmented and edited in 3D software. Subsequently, the surface deviations were examined to estimate their influence on the calculated results. The boundary conditions for the numerical simulation were taken from literature or are based on own investigations. To be able to simulate different variants, a parameter set in Microsoft Excel was programmed. Results: The model “Fully Toothed Dentition“ is very well suited for the qualitative and quantitative assessment of periodontal diseases. Own in-silico-validations with the models “Jaw Segment“ and “Extracted Tooth“ support this statement. The evaluation of the stresses and strains on the occlusal surfaces is of particular importance for prosthetic procedures. In this respect, the examined models show weaknesses. Qualitative statements could be determined by evaluating the stress and pressure curves. These are mandatory for adjustments of the tooth surfaces, but are not currently found in everyday clinical practice. In order to be able to make quantitative statements, further investigations are necessary in terms of the quality of meshing and the definition of the contact. Conclusion: To make economically feasible use of these calculations for prevention, control and post-treatment, further investigations with statistical evaluation are necessary. In the near future, results will be available in real time for an initially limited examination area and will represent new standards in medical imaging.
A METHODOLOGY TO IMPROVE SPEAKING SKILLS IN ENGLISH LANGUAGE LEARNING USING MOBILE APPLICATIONS  (Facebook, HelloTalk, Tandem, Duolingo)
Creators: name: Akhmadova Feruza Zarifovna 2nd year Master student in Samarkand State Institute of Foreign Languages  Kholmurodova Dilnoza Kholmurodovna Dean of the Faculty of Joint Educational Programs, PhD, Associate Professor
Publisher: name: Zenodo
Year: 2025

description: The development of mobile applications as language learning tools has created new possibilities for enhancing English speaking competence. The current paper presents an analysis of the effectiveness of Facebook, HelloTalk, Tandem, and Duolingo in facilitating speaking skill acquisition by learners. Based on close observation of the app-specific features and how they support language practice, this article gives a guide for students and teachers to incorporate these tools in the development of speaking skills. The paper has benefits, weaknesses, and useful tips, and it points to the potential of these apps to create interactive learning opportunities.
THE KINETICS OF SKYDIVE LANDINGS
Creators: name: Aiyed, Joyce
Publisher: name: Zenodo
Year: 2023
Subjects: ground reaction force
shear force
ankle sprain
parachute
landing

description: Skydiving landing mishaps have overwhelmed the sport as one of the largest causes of injury among licensed skydivers. Landing difficulties may be influenced by various kinetic and kinematic factors, which can contribute to musculoskeletal discomfort or injury development. There is a high prevalence of ankle and foot injuries among skydivers associated with skydive landings. Previous research surrounding airborne operations has focused on assessing the kinetics and kinematics of the parachute landing fall technique, parachute opening shock, and the simulated parachute half-squat. However, there is limited research regarding the kinetics of routine skydive landings. The purpose of this study is to measure the ground reaction forces during stand up skydive landings and compare them to the forces during a task commonly used to mimic a skydive landing, the drop landing. The kinetics of skydiving stand up landings have never been previously studied. Four skydive, 40 cm box landings, and 80 cm box landings were compared. It was found that vertical force was not significantly higher during landings from the 80 cm box compared to the 40 cm box. There were no statistically significant differences in vertical force between skydive landings and the 40 cm and 80 cm box drop landings. Shear forces were significantly greater during skydive landings compared to the 40 cm box drop landing (p ≤ 0.05). Also, 80 cm box landings had significantly more shear forces as compared to 40 cm box landings (p < 0.01). These results underscore the critical role of shear forces in injury risk, highlighting the need for further research to inform safety measures and injury prevention strategies within the realm of skydiving and aerial sports.
Transient fluctuation of the prosperity of firms in a network economy
Creators: name: Maeno, Yoshiharu
Publisher: name: arXiv
Year: 2011
Subjects: subject: Molecular Networks (q-bio.MN)
subject: Computational Engineering, Finance, and Science (cs.CE)
subject: Biological Physics (physics.bio-ph)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Biological sciences
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: The transient fluctuation of the prosperity of firms in a network economy is investigated with an abstract stochastic model. The model describes the profit which firms make when they sell materials to a firm which produces a product and the fixed cost expense to the firms to produce those materials and product. The formulae for this model are parallel to those for population dynamics. The swinging changes in the fluctuation in the transient state from the initial growth to the final steady state are the consequence of a topology-dependent time trial competition between the profitable interactions and expense. The firm in a sparse random network economy is more likely to go bankrupt than expected from the value of the limit of the fluctuation in the steady state, and there is a risk of failing to reach by far the less fluctuating steady state.
Evaluating farm hedgerows for their climate change mitigation potential in the lower Fraser River delta of British Columbia
Creators: name: Thiel, Bryanna
Publisher: name: University of British Columbia
Year: 2015

description: Hedgerows have potential to help mitigate greenhouse gas emissions from agricultural activities by sequestrating carbon in woody biomass and in soil. In the Fraser Valley of British Columbia, a hedgerow stewardship program supports farmers to plant hedgerows to create habitat for biodiversity conservation and to improve ecosystem services, but it is unclear how much hedgerows contribute to climate change mitigation. This study evaluated components of the mitigation potential of two types of hedgerows, those planted by the stewardship program, and those that are remnant in the region. We quantified the carbon stored in woody biomass and soil, and greenhouse gas emissions of these two hedgerow types relative to neighbouring production fields used for cultivation of annual crops. There was no significant difference in the biomass carbon in the two hedgerow types despite age differences. Woody vegetation species diversity was significantly greater in planted hedgerows than remnant hedgerows for richness, Shannon, and Simpson measures. Planted hedgerows stored greater soil carbon than remnant hedgerows to 1.2 t m-² standard soil mass. Soil carbon was significantly correlated with the Shannon, and Simpson diversity of the hedgerow shrubs and trees indicating that planting a diversity of woody species likely has a positive effect on the mitigation potential of hedgerows on farmland. Carbon dioxide, nitrous oxide, and methane effluxes from soil, measured bi-monthly for one year indicate that the mitigation potential is not straightforward. For the 6-month production and non-production seasons, carbon dioxide was significantly greater in hedgerows than production fields. Relative emissions, emissions from hedgerows relative to their neighbouring production fields, from planted hedgerows were significantly greater than remnant hedgerows. For the 6-month production season, nitrous oxide emissions were significantly lower in hedgerows than productions fields, while no difference were observed in the non-production season or between hedgerow types. No significant differences were observed between seasons or hedgerow types for methane fluxes. These findings suggest that planting hedgerows may be an important management option to store carbon on agricultural land in the Fraser River delta relative to remnant hedgerows, but their net impact on climate change mitigation is still unclear.
Vanishing of l^2-cohomology as a computational problem
Creators: name: Grabowski, Łukasz
Publisher: name: arXiv
Year: 2012
Subjects: subject: Group Theory (math.GR)
subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics

description: We show that it is impossible to algorithmically decide if the l^2-cohomology of the universal cover of a finite CW complex is trivial, even if we only consider complexes whose fundamental group is equal to the elementary amenable group (Z_2 \wr Z)^3. A corollary of the proof is that there is no algorithm which decides if an element of the integral group ring of the group (\Z_2 \wr Z)^4 is a zero-divisor. On the other hand, we show, assuming some standard conjectures, that such an algorithm exists for the integral group ring of any group with a decidable word problem and a bound on the sizes of finite subgroups.
description: 18 pages; rewritten following referee's reports; to appear in Bulletin of LMS
Serologische Längsschnittstudie von SARS-CoV-2 positiven Personen
Creators: name: Lange, Paul
Publisher: name: Otto-von-Guericke-Universität Magdeburg
Year: 2022
Subjects: subject: SARS-CoV-2
subject: Antikörperbildung
subject: 616.91

description: In der Arbeit wurde die humorale Immunantwort des Menschen auf SARS-CoV-2 untersucht. Die Serumproben, die in dieser Arbeit untersucht wurden, wurden klinisch und infektionsserologisch charakterisiert. Vier kommerzielle Assays wurden für die Bestimmung von Antikörpern gegen SARS-CoV-2 und weitere Coronaviren verwendet. Die Untersuchung der Antikörper Titer von SARS-CoV-2 positiven Personen zeigte signifikante Unterschiede je nach Schweregrad der Coronavirus-Erkrankung (COVID-19). In der Gruppe moderat bis schwer erkrankter Patienten fanden sich mehr neutralisierende Antikörper als in der asymptomatisch und leicht erkrankten Gruppe. Die Untersuchung der Patientenproben mit einem Peptid Microarray führte zur Identifizierung von immundominanten Epitopen. Die identifizierten Peptidsequenzen wurden mit den homologen Peptidsequenzen weiterer auf dem Peptid Microarray erfassten Coronaviren verglichen und auf kreuzreaktive Antikörper untersucht. Auf dem S und N Protein wurden Epitope identifiziert, die ausdrücklich Antikörperreaktivität für SARS-CoV-2 zeigten. Diese können für die Entwicklung eines Peptid-ELISA verwendet werden.
Vertical representation of $C^{\infty}$-words
Creators: name: Fédou, Jean-Marc
name: Fici, Gabriele
Publisher: name: arXiv
Year: 2012
Subjects: subject: Discrete Mathematics (cs.DM)
subject: Formal Languages and Automata Theory (cs.FL)
subject: FOS: Computer and information sciences
subject: 68R15

description: We present a new framework for dealing with $C^{\infty}$-words, based on their left and right frontiers. This allows us to give a compact representation of them, and to describe the set of $C^{\infty}$-words through an infinite directed acyclic graph $G$. This graph is defined by a map acting on the frontiers of $C^{\infty}$-words. We show that this map can be defined recursively and with no explicit references to $C^{\infty}$-words. We then show that some important conjectures on $C^{\infty}$-words follow from analogous statements on the structure of the graph $G$.
description: Published in Theoretical Computer Science
Neutron-Diffraction Measurements of an Antiferromagnetic Semiconducting Phase in the Vicinity of the High-Temperature Superconducting State of K$_x$Fe$_{2-y}$Se$_2$
Creators: name: Zhao, Jun
name: Cao, Huibo
name: Bourret-Courchesne, E.
name: Lee, D. -H.
name: Birgeneau, R. J.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The recently discovered K-Fe-Se high temperature superconductor has caused heated debate regarding the nature of its parent compound. Transport, angle-resolved photoemission spectroscopy, and STM measurements have suggested that its parent compound could be insulating, semiconducting or even metallic [M. H. Fang, H.-D. Wang, C.-H. Dong, Z.-J. Li, C.-M. Feng, J. Chen, and H. Q. Yuan, Europhys. Lett. 94, 27009 (2011); F. Chen et al. Phys. Rev. X 1, 021020 (2011); and W. Li et al.,Phys. Rev. Lett. 109, 057003 (2012)]. Because the magnetic ground states associated with these different phases have not yet been identified and the relationship between magnetism and superconductivity is not fully understood, the real parent compound of this system remains elusive. Here, we report neutron-diffraction experiments that reveal a semiconducting antiferromagnetic (AFM) phase with rhombus iron vacancy order. The magnetic order of the semiconducting phase is the same as the stripe AFM order of the iron pnictide parent compounds. Moreover, while the root5*root5 block AFM phase coexists with superconductivity, the stripe AFM order is suppressed by it. This leads us to conjecture that the new semiconducting magnetic ordered phase is the true parent phase of this superconductor.
description: 1 table, 4 figures,5 pages
title: Social Conflict and Control, Protest and Repression (Indochina)
title: Social Conflict and Control, Protest and Repression (Indochina)
Creators: name: Morlat, Patrice
Publisher: name: BSB - Bavarian State Library
Year: 2017
Subjects: subject: Indochina
subject: Weltkrieg [1914-1918]
subject: World War, 1914-1918
subject: Indochina

description: Vietnamese resistance to French colonial rule had begun before the war and continued throughout it. The Duy Tan League, founded in 1904, was the most significant of the revolutionary resistance groups: Often aided by secret societies in Cochinchina, it led several insurrection and raids on French colonial offices, prisons, and administrative hubs. In response and empowered by the wartime state of emergency, the colonial government reorganized its intelligence, police, and propaganda networks. The recruitment of some 100,000 Vietnamese “volunteers” as troops and labourers in France additionally disrupted local societies, while also reinforcing the colonial state’s repressive apparatus. Though the Duy Tan League was ultimately defeated, its disappearance opened the door for a far more organized new generation of revolutionaries who would come to prominence in the post-war years.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
The integration of vision and proprioception for obstacle crossing in people with motor-incomplete spinal cord injury
Creators: name: Malik, Raza Naseem
Publisher: name: University of British Columbia
Year: 2015

description: Background: In people with motor-incomplete spinal cord injury (m-iSCI), the ability to perform skilled walking tasks (e.g. obstacle crossing) is an essential component of functional mobility. Sensorimotor integration of visual and proprioceptive inputs, alongside indicators of functional ambulation (i.e. self-efficacy) is important for successful obstacle crossing. Thus, the overall objective was to understand how motor and sensory (specifically proprioception) deficits in people with m-iSCI affect obstacle-crossing strategies. Methods: Nine individuals with m-iSCI and 10 able-bodied controls were asked to step over an obstacle scaled to their motor abilities under full and obstructed vision conditions. An eye tracker was used to determine gaze behavior, motion capture analysis was used to determine toe kinematics relative to the obstacle, and electrogoniometers were used to determine peak ankle, hip and knee (dorsi)flexion angles during obstacle crossing. In subjects with m-iSCI, questionnaires were used to determine balance and ambulatory self-efficacy. Lower limb proprioceptive sense was assessed using a hip and knee joint position-matching task using the Lokomat and customized software controls. Results: Lower limb proprioceptive sense was impaired and varied across subjects with m-iSCI. m-iSCI subjects tended to glance at the obstacle more frequently as they approached it and with shorter gaze durations compared to controls. Decreased self-efficacy and impaired proprioceptive sense may have contributed to these differences in gaze behavior. Obstruction of the lower visual field led to appropriate modulation of lead and trail horizontal distance, however toe clearance height in m-iSCI subjects was increased to a greater extent than controls. An emerging relationship was observed between proprioceptive sense and toe clearance height, in particular for the trail limb. m-iSCI subjects increased peak knee flexion to a greater extent than controls when vision was obstructed. All other changes in joint kinematics were similar across groups. Conclusion: The results of this study indicate that people with m-iSCI rely more heavily on vision to cross obstacles and show impairments in the key gait parameters required for successful obstacle crossing. Our data suggest that proprioceptive deficits also need to be considered in rehabilitation programs aimed at improving functional mobility in individuals with m-iSCI.
Supplementary Materials for the paper 'a Review of R Neural Network Packages (with NNbenchmark): Accuracy and Ease of Use'
Creators: name: Mahdi, Salsabila
name: Verma, Akshaj
name: Dutang, Christophe
name: Kiener, Patrice
name: Nash, John C.
Publisher: name: Zenodo
Year: 2020
Subjects: Neural network
benchmark
R software

description: Supplementary materials for a forthcoming paper entitled 'a Review of R Neural Network Packages (with NNbenchmark): Accuracy and Ease of Use'
X-ray selected AGN Hosts are Similar to Inactive Galaxies out to z=3: Results from CANDELS/CDF-S
Creators: name: Rosario, D. J.
name: Mozena, M.
name: Wuyts, S.
name: Nandra, K.
name: Koekemoer, A.
name: McGrath, E.
name: Hathi, N.
name: Dekel, A.
name: Donley, J.
name: Dunlop, J. S.
name: Faber, S. M.
name: Ferguson, H.
name: Giavalisco, M.
name: Grogin, N.
name: Guo, Y.
name: Newman, J.
name: Kocevski, D. D.
name: Koo, D. C.
name: Laird, E.
name: Rangel, C.
name: Somerville, R.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We use multi-band spatially resolved photometry from the Cosmic Assembly Near-IR Deep Legacy Survey (CANDELS) in the 4 MSec Chandra Deep Field-South (CDF-S) to explore the nuclear and extended colors, color gradients and stellar populations of X-ray selected AGN host galaxies out to z=3. Based on a study of their central light, we develop X-ray based criteria to exclude objects with strong AGN contamination. We use stellar masses from the FIREWORKS database to understand and account for stellar mass selection effects, and carefully study, for the first time, the resolved host galaxy properties of AGNs at z~2 in their rest-frame optical light without substantial nuclear contamination. AGN hosts span a sizable range of stellar masses, colors and color gradients at these redshifts. Their colors, color gradients and stellar population properties are very similar to inactive galaxies of the same stellar mass. At z~1, we find a slightly narrower range in host colors compared to inactive galaxies, as well as hints of more recent star-formation. These differences are weaker or non-existent among AGN hosts at z~2. We discuss the importance of AGN driven feedback in the quenching of galaxies at z>~1 and speculate on possible evolution in the relationship between black hole accretion and the host galaxy towards high redshifts.
description: 20 pages, 14 figures
Synthesis and biological characterization of novel inhibitors of histone deacetylases as anticancer and antiparasitic agents [Kumulative Dissertation]
Creators: name: Ghazy, Ehab Mohamed Elbassiony
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 610

description: Die Epigenetik spielt eine wichtige Rolle in der modernen Medizinischen Chemie und Wirkstoffforschung. Zunächst wurde eine neue Reihe von humane HDAC8-Inhibitoren identifiziert, welche in Neuroblastomzellen eine starke Wirkung zeigten. Desweiteren wurden dual wirkende Inhibitoren von HDAC6/8 BRPF1 entwickelt. Benzhydroxamate wurden weiterhin gegen smHDAC8 untersucht und mehrere Inhibitoren zeigten eine bemerkenswerte Aktivität gegen Parasiten. Basierend auf diesen smHDAC8-Inhibitoren wurde ein Modell der quantitativen Struktur-Aktivitäts-Beziehung erstellt. Außerdem zeigten die Inhibitoren antileishmanische und cestozide Aktivität. Die in der aktuellen Arbeit erzielten Ergebnisse können potenzielle Ausgangspunkte für die weitere Optimierung neuerartiger HDAC-Inhibitoren für Krebs- und antiparasitäre Therapien darstellen.
description: Epigenetics has emerged to become an important field of modern medicinal chemistry and drug discovery. We identified selective human HDAC8 inhibitors with a strong HDAC8 inhibition phenotype in neuroblastoma cells. We applied the polypharmacology concept to design dual-acting inhibitors of HDAC6/8 BRPF1 bromodomains. Other benzhydroxamates were further synthesized against smHDAC8 showing a remarkable activity in vivo against the parasite. Based on these inhibitors, a quantitative structure-activity relationship (QSAR) model was generated and refined to predict the biological activity of novel compounds. The developed smHDAC8 inhibitors also showed antileishmanial and cestocidal activity. The results obtained in the current work could be used to optimize these novel chemotypes as HDAC inhibitors for anticancer and antiparasitic therapies.
Geometric integration of a constrained Cosserat beam model
Creators: name: Hante, Stefan
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 510

description: Die vorliegende Arbeit beschäftigt sich mit der numerischen Lösung der Bewegungsgleichungen eines Cosserat-Balkenmodells, welches mittels Zwangsbedingungen auf ein Kirchhoff-Balkenmodell reduziert wird. Diese Bewegungsgleichungen sind Differentialgleichungen auf Lie-Gruppen, die die Struktur eines semidirekten Produktes haben. Zur Parametrisierung der Orientierung im Raum werden Einheitsquaternionen verwendet. Die Bewegungsgleichungen des Balkens werden zunächst bezüglich des Ortes diskretisiert und führen dann auf differential-algebraische Gleichungen vom Index 3 auf einer höherdimensionalen Lie-Gruppe. Zur Lösung dieser Gleichungen wird ausgehend vom bekannten RATTLE-Verfahren ein neuer Algorithmus „RATTLie“ hergeleitet, der der Klasse der variationellen Integratoren zuzuordnen ist. Es wird bewiesen, dass RATTLie mit zweiter Ordnung konvergiert. Die Untersuchungen werden durch zahlreiche numerische Experimente untermauert.
description: The present thesis is concerned with the numerical solution of the equations of motion of a Cosserat beam model which is reduced to a Kirchhoff beam model by introducing constraints. The equations of motion take the form of differential equations on Lie groups with the structure of a semi-direct product. To parametrize orientation in space, we use unit quaternions. First, we discretize the equations of motion of the beam in space. This leads to differential-algebraic equations of index 3 on a higher dimensional Lie group. Second, in order to solve these equations, we develop a new algorithm called “RATTLie”. It belongs to the class of variational integrators and is based on the wellknown RATTLE method. We prove that RATTLie converges with second order. Finally, we carry out several numerical experiments that confirm our analytical considerations.
Mechanisms of survival against desiccation and associated stresses of the soil-residing actinomycete Rhodococcus jostii strain RHA1
Creators: name: LeBlanc, Justin Christian
Publisher: name: University of British Columbia
Year: 2015

description: Actinomycetes are an abundant bacterial group in soil, with a critical role in the decomposition of organic matter. Rhodococcus jostii strain RHA1 is of particular interest to the field of bioremediation because it can degrade a broad range of organic compounds, both natural and xenobiotic. Understanding the factors contributing to the desiccation resistance of RHA1 will enrich our basic knowledge of this common soil stress and may help advance bioremediation technologies for contaminated soils subject to droughts. Here I report the first transcriptomic analysis of a Gram-positive bacterium during desiccation. Filtered RHA1 cells incubated at either low relative humidity, as an air-drying treatment, or high relative humidity, as a control, were transcriptionally profiled over a comprehensive time series. Also, the morphology of RHA1 cells was characterized by cryofixation scanning electron microscopy during each treatment. Desiccation resulted in a transcriptional response of 819 differentially regulated genes, 8-times more than in the control. Included among the highly up-regulated desiccation-specific genes was dps1 (induced 33-fold), encoding an oxidative stress protection protein which has not previously been directly associated with desiccation, as well as sigF3 (induced 58-fold), encoding a sigma factor possibly involved in the regulatory response to desiccation. RHA1 mutants with dps1 or both of its dps homologs deleted were challenged with oxidative stressors under a variety of assay conditions. The mutants were also exposed to physiological stresses that generate reactive oxygen species intracellularly, including desiccation. In all cases, the dps− mutants did not have impaired oxidative stress resistance – a novel finding with respect to bacterial dps-null strains. Additionally, the RHA1 dps-null mutant did not have substantially lower survival compared to the wild type when challenged with metal toxicity or DNA-damaging agents or when they were cocultured through multiple cycles of starvation. Nevertheless, expression of RHA1 dps1 in an Escherichia coli dps– mutant restored its hydrogen peroxide resistance. Purified RHA1 Dps1 was shown to have ferroxidase activity and thereby to protect DNA from oxidative damage. The general insensitivity of the RHA1 dps-null mutant may be representative of a large group of Actinobacteria for which robust oxidative stress tolerance is an important adaptation.
Untersuchungen zu medikamenteninduzierter Freisetzung extrazellulärer Nukleinsäuren von in vitro kultivierten humanen Lungenkarzinomzellen
Creators: name: Rode, Florian
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 610

description: Extrazelluläre Nukleinsäuren als Biomarker dienen als neuer Ansatz in der Behandlung von Tumorpatienten. Die DNA-Methylierung Tumor-assoziierter Gene lässt sich in zellfreier DNA (cfDNA) nachweisen. Die Mechanismen der Freisetzung cfDNA und ein Zusammenhang zwischen Pharmakotherapie und Methylierung sind bisher kaum untersucht. Ziel dieser Arbeit ist, zu untersuchen, ob eine Pharmakotherapie Einfluss auf die Methylierung von cfDNA hat. Hier konnte gezeigt werden, dass bei allen untersuchten Medikamenten bei allen Zelllinien unterschiedliche Veränderungen der cfDNA-Methylierung der untersuchten Gene im Kulturüberstand auftreten. Unter Cisplatin- und Prednisolon-Behandlung zeigten sich bei zwei Zelllinien Trends hinsichtlich einer Veränderung der Methylierung des Gens SHOX2. Im Zeitverlauf der Zellkultivierung kam es zu einer Zunahme der cfDNA-Konzentration im Überstand der Zellen; es konnte hierbei kein Zusammenhang zwischen cfDNA-Konzentration und dem Zelluntergang beobachtet werden.
description: Extracellular nucleic acids are novel biomarkers for the treatment strategy of cancer patients. DNA methylation of tumor associated genes can be detected in cell free DNA (cfDNA). The mechanisms of cfDNA release as well as the context between pharmacotherapy and DNA methylation are so far barely understood. The aim of this thesis is to investigate if pharmacotherapy affects cfDNA methylation. It was shown that all tested drugs have distinct effects on DNA methylation of the investigated genes in the supernatant of the examined cell lines. Upon treatment with cisplatin and prednisolone alterations of DNA methylation of the gene SHOX2 could be observed in two cell lines. In the course of time an increase of cfDNA concentration was detected in the supernatant of cells, while there was no correlation between cfDNA concentration and cell degradation.
Changes in silicatic raw material procurement in western Ukraine  - First results
Creators: name: Wehren, Helena
name: Affolter, Jehanne
name: Kiosak, Dmytro
Publisher: name: Zenodo
Year: 2019
Subjects: siliceous artefacts
material determination
raw material procurement

description: Knowledge on the distribution of artefacts and on their source of raw material allows to get insights into prehistoric contacts and the area of movement. Samples of the archaeological sites Melnychna Krucha, Kamyane Zavallia and Mogylna III in Ukraine have been investigated. The chosen archaeological sites cover a timespan of more than 3500 years.

With the sedimentary microfacies we can determine the geological attribution of the mother rock. Therefore, it gives us clues about raw material provenience.
title: Lectures du Théétète
Publisher: name: Centre Jean Pépin  UMR 8230 ENS Paris-CNRS-PSL
Year: 2023

description: 2023-2024  - 1er semestre - Lectures du Théétète
Le Théétète met en scène un Socrate qui s’intéresse non plus aux questions éthiques et politiques comme dans les dialogues de jeunesse et de la maturité, mais à une question épistémologique, la définition de la science (épistèmè), comme le Sophiste qu’il annonce. On notera que la discussion a pour préambule la construction par Théodore de longueurs « irrationnelles ». Dans un premier temps, Socrate explique comment il conçoit la pédagogie non comme la transmission d’un savoir, mais comme l’accouchement d’une vérité que chacun possède en lui-même. Puis on passe à la définition de la science. La science ne peut résider dans la sensation comme le prétend Protagoras. On serait amené par là un relativisme plus ou moins absolu. La science ne peut non plus résider dans l’opinion vraie, pas même accompagnée de définition : mais est-il possible que des éléments qui ne peuvent être définis puissent contribuer à la définition d’un tout, compte tenu de surcroît que le terme « définition » présente plusieurs sens ?
Mother Operators and their Descendants
Creators: name: Picard, Rainer
name: Trostorff, Sascha
name: Waurick, Marcus
Publisher: name: arXiv
Year: 2012
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 47F05

description: A mechanism deriving new well-posed evolutionary equations from given ones is inspected. It turns out that there is one particular spatial operator from which many of the standard evolutionary problems of mathematical physics can be generated by this abstract mechanism using suitable projections. The complexity of the dynamics of the phenomena considered can be described in terms of suitable material laws. The idea is illustrated with a number of concrete examples.
description: This is a revised version of the earlier posted pre-print. The corrections concern predominantly Corollary 1.7 and Theorem 1.9 and their consequences
Civic education as an approach to democracy in Russia and Ukraine
Creators: name: Orr, Matthew Rutland
Publisher: name: The University of Texas at Austin
Year: 2021
Subjects: Democracy
Civics
Civic education
Russia
Ukraine

description: This thesis uses historical and qualitative content analysis to understand the role that civic education has played in the development of democracy in Russia and Ukraine since the fall of the Soviet Union. It draws on global and regional discourses of democratization to argue that civic education has been an underappreciated factor by politicians, policymakers, and scholars seeking to shape or explain the political past, present, and future of Russia and Ukraine. Specifically, it argues that civics curriculum in both countries has been plagued by fundamental flaws stimming from their common Soviet history, the reaction to which has shaped each country’s modern political trajectory. While Ukraine has made great strides in recent years to reform civics, Russia’s civic education regime remains startlingly underdeveloped over the past 30 years, a fundamental obstacle that those interested in Russia’s democratization have failed to draw sufficient attention to
Transgenerational transfer of dietary lipids and its consequences for offspring physiology in a marine teleost
Creators: name: Hou, Zhenxin
name: 0000-0002-1301-0799
Publisher: name: The University of Texas at Austin
Year: 2021
Subjects: Lipid metabolism
Fatty acid
Marine fish
Nutrition

description: Maternal provisioning of nutrients can play a key role in the growth, development and long-term fitness of offspring. In teleosts, the composition of maternally derived nutrients (in yolk and oil) depends partly on maternal diet. This dissertation investigates the process of maternal-offspring nutrient transfer and the transgenerational effects of maternal nutrition on offspring physiology in a marine teleost, red drum (Sciaenops ocellatus). Results of 21 diet-shift experiments, from which the fatty acid profiles of the diets and eggs were compared, showed that 15 fatty acids in eggs were correlated with their levels in the recent diet, and the rate of incorporation of fatty acids into eggs was proportional to the magnitude of the diet shift. Further assessment revealed that maternal diet affected egg triglyceride (TG) content but not other lipid classes. Parental dietary variations rapidly affected the fatty acid composition of all major lipid classes in eggs (TG, wax ester/steryl ester (WE/SE), and phosphatidylcholine (PC)), with greater effects on neutral lipids (TG, WE/SE) than on the polar lipid (PC). Rates at which embryos and larvae utilized 15 fatty acids varied with maternal diet and were proportional to their initial concentrations in eggs. Rates of utilization of the oil globule were also affected by maternal diet, resulting in differences in oil globule size at the first feeding stage. Effects of different maternal diets on larval fatty acid compositions persisted at the time of onset of exogenous feeding and afterward. In addition, prolonged effects of maternal nutrition on larval lipid metabolism (nutritional programming) were documented. At 21 days post-hatching (dph), larvae reared under common conditions from eggs produced by adults on different diets showed differences in total fatty acid accumulation and fatty acid profiles (especially polyunsaturated fatty acids in TG). Collectively, these research findings demonstrate some of the profound transgenerational effects of maternal nutrition on offspring physiology. The altered lipid metabolism of offspring resulting from variations in parental diet may have consequences for larval physiological processes and behavioral performance, which may ultimately influence their survival and fitness
Why does attention to web articles fall with time?
Creators: name: Simkin, M. V.
name: Roychowdhury, V. P.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Information Retrieval (cs.IR)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: We analyze access statistics of a hundred and fifty blog entries and news articles, for periods of up to three years. Access rate falls as an inverse power of time passed since publication. The power law holds for periods of up to thousand days. The exponents are different for different blogs and are distributed between 0.6 and 3.2. We argue that the decay of attention to a web article is caused by the link to it first dropping down the list of links on the website's front page, and then disappearing from the front page and its subsequent movement further into background. The other proposed explanations that use a decaying with time novelty factor, or some intricate theory of human dynamics cannot explain all of the experimental observations.
description: To appear in JASIST
A Modified GHG Intensity Indicator: Toward a Sustainable Global Economy based on a Carbon Border Tax and Emissions Trading
Creators: name: Moghaddam, Reza Farrahi
name: Moghaddam, Fereydoun Farrahi
name: Cheriet, Mohamed
Publisher: name: arXiv
Year: 2011
Subjects: subject: General Finance (q-fin.GN)
subject: FOS: Economics and business

description: It will be difficult to gain the agreement of all the actors on any proposal for climate change management, if universality and fairness are not considered. In this work, a universal measure of emissions to be applied at the international level is proposed, based on a modification of the Greenhouse Gas Intensity (GHG-INT) measure. It is hoped that the generality and low administrative cost of this measure, which we call the Modified Greenhouse Gas Intensity measure (MGHG-INT), will eliminate any need to classify nations. The core of the MGHG-INT is what we call the IHDI-adjusted Gross Domestic Product (IDHIGDP), based on the Inequality-adjusted Human Development Index (IHDI). The IDHIGDP makes it possible to propose universal measures, such as MGHG-INT. We also propose a carbon border tax applicable at national borders, based on MGHG-INT and IDHIGDP. This carbon tax is supported by a proposed global Emissions Trading System (ETS). The proposed carbon tax is analyzed in a short-term scenario, where it is shown that it can result in significant reduction in global emissions while keeping the economy growing at a positive rate. In addition to annual GHG emissions, cumulative GHG emissions over two decades are considered with almost the same results.
description: Accepted for publication in Energy Policy (Elsevier)
Einstein equation at singularities
Creators: name: Stoica, Ovidiu-Cristinel
Publisher: name: arXiv
Year: 2012
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Mathematical Physics (math-ph)
subject: Differential Geometry (math.DG)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: Einstein's equation is rewritten in an equivalent form, which remains valid at the singularities in some major cases. These cases include the Schwarzschild singularity, the Friedmann-Lemaître-Robertson-Walker Big Bang singularity, isotropic singularities, and a class of warped product singularities. This equation is constructed in terms of the Ricci part of the Riemann curvature (as the Kulkarni-Nomizu product between Einstein's equation and the metric tensor).
description: 12 pages. Ovidiu-Cristinel Stoica, Cent. Eur. J. Phys., 2014, 10.2478/s11534-014-0427-1
Variance of partial sums of stationary sequences
Creators: name: Deligiannidis, George
name: Utev, Sergey
Publisher: name: arXiv
Year: 2012
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: Let $X_1,X_2,\ldots$ be a centred sequence of weakly stationary random variables with spectral measure $F$ and partial sums $S_n=X_1+\cdots+X_n$. We show that $\operatorname {var}(S_n)$ is regularly varying of index $γ$ at infinity, if and only if $G(x):=\int_{-x}^xF(\mathrm {d}x)$ is regularly varying of index $2-γ$ at the origin ($0
description: Published in at http://dx.doi.org/10.1214/12-AOP772 the Annals of Probability (http://www.imstat.org/aop/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Migrantes no tienen alma, migrantes solo tienen pies : social challenges of returnee women in Guatemala
Creators: name: Alvarez Velez, Rosa Isela
name: 0000-0001-9011-6231
Publisher: name: The University of Texas at Austin
Year: 2020
Subjects: Women
Returnees
Return migration
Reintegration
Migration

description: Scholarship on return migration has historically focused on the return experiences of men, lacking comparison and specificity on women’s experiences. This qualitative study of returnee women in Guatemala focuses on how their roles and identities as daughters, mothers, and retirees, influence their return and reintegration processes into Guatemalan society, as well as the way they make meaning of their experiences. However, regardless of generational status, returnee women face social challenges related to family separation, travel restrictions, judgments and social clashes, and family reintegration, which have a great impact on their health and well-being of their families. Finally, this thesis explores the ways the social work field can work to advocate for and provide necessary social services to help returnee women through their return and reintegration processes
Motives and outcomes of vertical coordination from the processors’ perspective - insights from the Ukrainian dairy industry
Creators: name: Hahlbrock, Maryna
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2014
Subjects: subject: Ukraine
subject: Milchwirtschaft
subject: Supply Chain Management
subject: Online-Publikation
subject: Hochschulschrift
subject: 650
subject: 630

description: Die effiziente Organisation der Beziehungen zwischen Käufern und Lieferanten, sowie einer nachhaltigen Lieferkette sind die größten Herausforderungen der Ukrainischen Milchindustrie. Das Ziel dieser Arbeit besteht darin, die Organisation der Lieferkette und die wichtigsten Motive und Auswirkungen der vertikalen Koordination zu analysieren. Den konzeptionellen Rahmen bilden die Transaktionskosten- und Ressourcentheorie. Vervollständigt wird das Konzept durch Aspekte des Qualitätsmanagements, des Vertrauens und der Performance. Die Transaktionskostentheorie bietet einen geeigneten Erklärungsansatz für die Auswirkungen der Planungsunsicherheit und der Faktorspezifität auf die Vertragsgestaltung und das Ausmaß der gemeinsamen Aktivitäten zwischen den Milchlieferanten und den Verarbeitungsunternehmen. Die Rolle der vorhandenen Ressourcen für die Wahl der Koordinationsformen wird mit Hilfe des Ressourcenbasierten Ansatzes analysiert. Die Konzepte des Qualitätsmanagements, des Vertrauens und der Performance werden angewandt um die Komplexität und die Zusammenhänge in den Käufer-Lieferanten Beziehungen zu ergründen.
description: The efficient organization of buyer-supplier relationships and sustainable milk supply chain represent major challenges to the Ukrainian dairy sector. The main objective of this dissertation is to analyze the organization of the buyer-supplier relationship and the current issues of vertical coordination. The analysis refers to the main drivers and the outcomes of vertical coordination implemented by the Ukrainian milk processing companies. The conceptual framework refers to transaction cost theory and the resource-based view supported by the concepts of quality management, trust and firm performance. The transaction cost theory offers an appropriate approach to explain the impact of planning uncertainty and asset specificity on different forms of contractual governance and joint action between milk suppliers and processing companies. The role of the available resources for vertical coordination has been analyzed through the lens of the resource-based view of the firm. The concepts of quality management, trust and firm performance have been applied to understand the complexity and interrelations in the buyer-supplier relationship.
A note on the 1-prevalence of continuous images with full Hausdorff dimension
Creators: name: Fraser, Jonathan M.
name: Hyde, James T.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Metric Geometry (math.MG)
subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 28A80, 28A78

description: We consider the Banach space consisting of real-valued continuous functions on an arbitrary compact metric space. It is known that for a prevalent (in the sense of Hunt, Sauer and Yorke) set of functions the Hausdorff dimension of the image is as large as possible, namely 1. We extend this result by showing that `prevalent' can be replaced by `1-prevalent', i.e. it is possible to \emph{witness} this prevalence using a measure supported on a one dimensional subspace. Such one dimensional measures are called \emph{probes} and their existence indicates that the structure and nature of the prevalence is simpler than if a more complicated `infinite dimensional' witnessing measure has to be used.
description: 8 pages
Dolastatin und seine Wirkung in der Proliferationsinhibition von humanen Gefäßmuskelzellen
Creators: name: Behr, Hagen
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2012
Subjects: subject: Online-Publikation
subject: Hochschulschrift
subject: 611

description: Gefäßmuskelzellen spielen eine herausragende Rolle bei der Entstehung der Restenose nach Ballondilatation in stenosierten Koronarien. Dolastatin 15 verhindert nach lokaler Applikation die Restenose. Zur Untersuchung der Beeinflussung der proliferationsrelevanten Gene P21, P53, Cyclin A2 und Cortactin wurden humane Gefäßmuskelzellen in Zellkulturen gezüchtet. Als Proliferationsstimuli wurden 10 % FCS und 5 ng/ml IL-1 verwendet. In Proliferations Zell-ELISA, Zellzählungen und S-Phase Analysen im FACS inhibierte 10 µM Dolastatin die Proliferation vollständig. Bei unstimulierten Zellen und FCS stimulierten Zellen zeigten sich unter Dolastatingabe in der RT-PCR, in der Real-Time PCR und im Western Blot teilweise eine signifikante Heraufregulationen von P21. Unter IL-1 Stimulation zeigte Dolastatin keinen Einfluss auf die P21 Regulation, jedoch zeigte sich ein statistisch signifikantes Absinken der Cyclin A2 mRNA. P53 und Cortactin wurden durch Dolastatin nicht beeinflusst.