cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Galaxy cluster number count data constraints on cosmological parameters
Creators: name: Campanelli, L.
name: Fogli, G. L.
name: Kahniashvili, T.
name: Marrone, A.
name: Ratra, Bharat
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: [Abridged] We use data on massive galaxy clusters ($M_{\rm cluster} > 8 \times 10^{14} h^{-1} M_\odot$ within a comoving radius of $R_{\rm cluster} = 1.5 h^{-1}\Mpc$) in the redshift range $0.05 \lesssim z \lesssim 0.83$ to place constraints, simultaneously, on the nonrelativistic matter density parameter $Ω_m$, on the amplitude of mass fluctuations $σ_8$, on the index $n$ of the power-law spectrum of the density perturbations, and on the Hubble constant $H_0$, as well as on the equation-of-state parameters $(w_0,w_a)$ of a smooth dark energy component. For the first time, we properly take into account the dependence on redshift and cosmology of the quantities related to cluster physics: the critical density contrast, the growth factor, the mass conversion factor, the virial overdensity, the virial radius and, most importantly, the cluster number count derived from the observational temperature data. We show that, contrary to previous analyses, cluster data alone prefer low values of the amplitude of mass fluctuations, $σ_8 \leq 0.69 (1σC.L.)$, and large amounts of nonrelativistic matter, $Ω_m \geq 0.38 (1σC.L.)$, in slight tension with the $Λ$CDM concordance cosmological model, though the results are compatible with $Λ$CDM at $2σ$. In addition, we derive a $σ_8$ normalization relation, $σ_8 Ω_m^{1/3} = 0.49 \pm 0.06 (2σC.L.)$.
description: 29 pages, 9 figures, 4 tables. Minor changes, references added. To appear in THE European Physical Journal C
title: Induction of erythroid differentiation in rat erythroleukaemic (REL) cells
Creators: name: Alcorn, Michael Joseph
Publisher: name: University of Glasgow
Year: 1995
Subjects: subject: Cellular biology.

description: The work presented here was an attempt to characterise some properties of a rat erythroleukaemic cell line (REL), in particular, the ability of these cells to undergo erytliroid differentiation following exposure to dimethylsulphoxide (DMSO). Erythroid differentiation was readily demonstrated by the appearance of haemoglobin in REL cells, using the benzidine reaction. Although it required some 72 hours exposure to DMSO before significant numbers of haemoglobinized cells could be detected, it appeared that some cells became committed to differentiate after as little as 8 hours exposure. It was possible to propose a sequence of events when REL cells were exposed to DMSO. After 4 hours of DMSO, DNA synthesis was down- regulated and REL cells started to shift out of S-phase of the cell cycle (i.e. proliferative) and started to accumulate in G0/G1(i.e. quiescent). This loss of proliferative ability was reflected in a reduction in cloning efficiency, i.e. some cells could no longer divide. Cells became committed to differentiation by 8 hours and by 24 hours, gross morphological changes could be observed, e.g. a significant reduction in cell size, cells adopting a smooth surface appearance as demonstrated by scanning electron microscopy (SEM). Cells producing haemoglobin could be detected by 72 hours of DMSO and the number of cells rose to a maximum after about 96 hours. It would appear that haemoglobin production is a relatively late event in DMSO-induced erytliroid differentiation of REL cells. To try to identify the biological activities that regulate differentiation, REL cells were adapted to a chemically defined, serum-free (SF) medium. Although the growth and division of these cells was not significantly different from cells grown in serum-containing medium, without serum, REL cells could not be induced to differentiate. Even when SF medium was supplemented with combinations of known growth factors / cytokines, no significant erythroid differentiation was obtained. It is because of this ability to differentiate along an erythroid pathway that the REL cells are regarded as erythroleukaemic. However, under certain culture conditions, REL cells developed characteristics associated with monocyte / macrophage maturation as demonstrated by morphology, appearance under SEM, cytochemical analyses, and expression of a macrophage-associated surface antigen. It would appear that REL cells are not restricted to the erythroid lineage, but, in fact, they retain the potential to mature along additional lineages. Brief cytogenetic analysis revealed the presence of a chromosomal abberation, namely, the translocation of the major portion of chromosome 3 to the terminal region of chromosome 1. The area of the breakpoint on chromosome 3 contains the protooncogene, c-abl. It may be that this translocation subverts the normal expression of c-abl and this aberrant expression contributes to the unregulated growth of REL cells.
Expression von VGF bei CD14- und CD19-exprimierenden Zellen bei Patienten mit Alzheimer-Demenz, vaskulärer Demenz und neuropsychiatrisch gesunden Kontrollpersonen
Creators: name: Meyer, Eva Christina
Publisher: name: Otto-von-Guericke-Universität Magdeburg
Year: 2021
Subjects: subject: Demenz
subject: B-Lymphozyt
subject: Monozyt
subject: 616.83107

description: Mit zunehmendem Alter auftretende Veränderungen des peripheren Immunsystems werden als Immunseneszenz bezeichnet und können ein chronisches Entzündungsgeschehen, das sogenannte „Inflammaging“, hervorrufen. Immunseneszenz und „Inflammaging“ beschränken sich nicht nur auf das periphere Immunsystem, sondern können Einfluss auf das zentrale Nervensystem und die Entwicklung neurodegenerativer Erkrankungen wie die Alzheimer-Demenz und vaskuläre Demenz nehmen. VGF ist ein Glykoprotein, das Funktionen der Neurogenese übernimmt und dessen Expression bei Patienten mit neuropsychiatrischen Erkrankungen verändert sein kann. In dieser Arbeit wurde die Verteilung von CD14+-Monozyten, als Bestandteil des erworbenen Immunsystems, und die Verteilung von CD19+-B-Lymphozyten, als Bestandteil des adaptiven Immunsystems, bei 38 Patienten mit Alzheimer-Demenz, fünf Patienten mit vaskulärer Demenz und 20 neuropsychiatrisch gesunden Kontrollpersonen untersucht. Es konnte kein Unterschied der prozentualen Verteilung festgestellt werden. Außerdem wurde die Anzahl VGF-exprimierender Monozyten und B-Lymphozyten analysiert. Es ergab sich eine signifikant höhere Anzahl VGF-exprimierender Monozyten bei Patienten mit vaskulärer Demenz im Vergleich zu Patienten mit einer Alzheimer-Demenz. Nach einer zwölfwöchigen medikamentösen Therapie mit Memantin oder Rivastigmin bei 17 Alzheimer-Demenz Patienten konnte keine veränderte Anzahl VGF-exprimierender Monozyten und B-Lymphozyten festgestellt werden. Eine erhöhte Anzahl VGF-exprimierender Monozyten könnte ein Charakteristikum einer vaskulären Demenz sein.
The American Soldier in World War II: Attitudes Toward USO Clubs
Creators: name: Research Branch, Information
Publisher: name: Roper Center for Public Opinion Research
Year: 2021

description: United Service Organizations (USO) clubs; distance from camp to nearest town; transportation to town; USO club attendance; reasons for attending USO club; most important things within a USO club; impressions of USO employees; impression of USO clubs; ordering soldiers to USO clubs; civilian occupation; job opportunities after war; USO clubs and employment problems; religion; recreation.
Statistical modeling of ground motion relations for seismic hazard analysis
Creators: name: Raschke, Mathias
Publisher: name: arXiv
Year: 2012
Subjects: subject: Geophysics (physics.geo-ph)
subject: FOS: Physical sciences
subject: 86

description: We introduce a new approach for ground motion relations (GMR) in the probabilistic seismic hazard analysis (PSHA), being influenced by the extreme value theory of mathematical statistics. Therein, we understand a GMR as a random function. We derive mathematically the principle of area-equivalence; wherein two alternative GMRs have an equivalent influence on the hazard if these GMRs have equivalent area functions. This includes local biases. An interpretation of the difference between these GMRs (an actual and a modeled one) as a random component leads to a general overestimation of residual variance and hazard. Beside this, we discuss important aspects of classical approaches and discover discrepancies with the state of the art of stochastics and statistics (model selection and significance, test of distribution assumptions, extreme value statistics). We criticize especially the assumption of logarithmic normally distributed residuals of maxima like the peak ground acceleration (PGA). The natural distribution of its individual random component (equivalent to exp(epsilon_0) of Joyner and Boore 1993) is the generalized extreme value. We show by numerical researches that the actual distribution can be hidden and a wrong distribution assumption can influence the PSHA negatively as the negligence of area equivalence does. Finally, we suggest an estimation concept for GMRs of PSHA with a regression-free variance estimation of the individual random component. We demonstrate the advantages of event-specific GMRs by analyzing data sets from the PEER strong motion database and estimate event-specific GMRs. Therein, the majority of the best models base on an anisotropic point source approach. The residual variance of logarithmized PGA is significantly smaller than in previous models. We validate the estimations for the event with the largest sample by empirical area functions. etc.
LiftWEC Deliverable D2.1: Preliminary Report on Synthesis of Design Knowledge
Creators: name: Lamont-Kane, Paul
name: Folley, Matt
Publisher: name: Zenodo
Year: 2020
Subjects: LiftWEC
Wave Energy
Wave Energy Converter
Lift-Based Wave Energy Converter
H2020 Deliverable

description: This document constitutes Deliverable ‘D2.1 Preliminary Report on Synthesis of Design Knowledge’ of the LiftWEC project. LiftWEC is a collaborative research project funded by the European Union’s Horizon 2020 Research and Innovation Programme under Grant Agreement No 851885. It is the intention of the project consortium that the LiftWEC project culminates in the identification of one or more promising configurations of a Wave Energy Converter operating through the use of a rotating hydrofoil that generates lift as the primary interaction with the incident waves. This report is intended to provide a preliminary foundation of the knowledge required to undertake the design of LiftWEC configurations in the project.
description: This work was produced as part of the LiftWEC Project. This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 851885. This output reflects the views only of the author(s), and the European Union cannot be held responsible for any use which may be made of the information contained therein.
Die Rolle von DYNLT1 und UCHL1 als prognostische Biomarker in Gliomen und Glioblastomen
Creators: name: Lehmann-Abi-Haidar, Jad
Publisher: name: Otto-von-Guericke-Universität Magdeburg
Year: 2021
Subjects: subject: Glioblastom
subject: Astrozytom
subject: Biomarker
subject: 616.99481

description: Gliome sind aggressive, primäre Hirntumore, die trotz aktueller Fortschritte in den Bereichen der Diagnostik und Therapie mit einer schlechten Prognose einhergehen. Es besteht demnach ein dringender Bedarf, neue zelluläre und molekulare Mechanismen, die die Pathophysiologie dieser Tumore regulieren, zu identifizieren. Dynein light chain 1 (DYNLT1, Tctex-1) ist Bestandteil des Dynein-Motor-Komplexes und spielt eine wichtige Rolle im Rahmen des Zellzyklus. Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) ist ein deubiquitinierendes Enzym, welches in mehreren soliden Tumor-entitäten aberrant exprimiert wird. In der vorliegenden Studie wurden die beiden potentiellen Biomarker DYNLT1 und UCHL1 analysiert und in Bezug auf deren Prognosefähigkeit bei Patienten mit Astrozytomen und Glioblastomen (GBM) beurteilt.
CBS News Poll: George W. Bush/Hurricane Katrina/Iraq
Creators: name: CBS News
Publisher: name: Roper Center for Public Opinion Research
Year: 2021

description: George W. Bush job performance (1); direction of country (1); most important problem (1); George W. Bush job performance (12); economic conditions (2); Congressional job performance (1); partisan Congressional performance (4); Medicare prescription drug benefits (1); legal immigration (1); immigrant employment (2); civilian border patrol (1); national border patrol (1); war with Iraq (1); cost of removing Saddam Hussein (1); personal financial situation (2); Tom DeLay (1); effect of gas prices (2); government energy priority (2); blame on increased oil prices (3); government role (1); confidence in government (2); paying for hurricane recovery (5); opinion of New Orleans (1); nominees to Supreme Court (1); Harriet Miers (2); views on creation/evolution (4); military action against Iraq (7); removal of Saddam Hussein (1); Hussein involvement in September 11 (1); Hussein and Al Qaeda (1); knowledge of others in Hurricane Katrina (2); belief in afterlife (2); belief in supernatural (2); Internet use and blogging (1).
Reaching generalized critical values of a polynomial
Creators: name: Jelonek, Zbigniew
name: Kurdyka, Krzysztof
Publisher: name: arXiv
Year: 2012
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14 D 06, 14 Q 20

description: Let f be a real or complex polynomial. We give an algorithm to compute the set of generalized critical values. The algorithm uses a finite dimensional space of rational arcs along which we can reach all generalized critical values of f.
description: 11 pages, revised version, to appear in Math. Z
The Mechanism of Action of a New Class of Nucleoside Analogs Targeting Gastrointestinal Tumours
Creators: name: Collins, Laura
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2019
Subjects: Nucleoside Analogs
Pancreatic Cancer

description: Gastrointestinal malignancies such as liver and pancreatic cancers are the deadliest due to late detection and drug resistance. Nucleoside analogues, like Gemcitabine, are the conventional therapy despite their little impact on survival and off-target toxicity. A novel class of nucleoside analogues able to evade drug resistance mechanisms has been developed by the Guindon group and biologically screened in our lab. Some of these proprietary molecules were further equipped with a lipoate moiety designed to target cancer cell metabolism. LCB2151 and LCB2179 have emerged as the lead molecules in this class, with an IC50 of 10-15 µM in the Gemcitabine-resistant human pancreatic (Capan-2 & Panc-1) cancer cell lines. The focus of this project is deciphering the cellular mechanisms activated by LCB2151 in these pancreatic cancer lines. A series of biased molecular approaches, like gene expression profiling, and unbiased large throughput proteomic and metabolomics analyses were applied to identify potential targets and affected pathways. Results collectively show that LCB2151 evades drug resistance mechanisms, increases pro-apoptotic markers and impairs mitochondrial respiration as early as 6 hours posttreatment. Furthermore, MS/MS analyses reveal that LCB2151 alters the levels of several metabolites in the central carbon metabolism pathway and identifies the citric acid cycle enzyme α-ketoglutarate dehydrogenase as a potential molecular target of LCB2151. Understanding the exact mechanism of action of our lead molecule along with extensive testing on murine cancer models, will surely pave its way to clinical testing and evaluation.
Sepsis-assoziierte Veränderungen in der Expression von mikroRNAs im Serum als diagnostischer Biomarker
Creators: name: Link, Fabian
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 610

description: In dieser Dissertation wurde die Eignung von miRNAs als Biomarker für Sepsis untersucht und mit etablierten diagnostischen Parametern verglichen. Hierfür wurden Blutproben septischer und nichtseptischer Intensivpatienten sowie gesunder Blutspender analysiert. Es konnte keine miRNA mit optimalen Eigenschaften für die diagnostische Verwendung identifiziert werden. Dennoch zeigte sich, dass die Berücksichtigung ausgewählter miRNAs in diagnostischen Scores einen Mehrwert bieten kann. Um folgende Untersuchungen auf qRT-PCR-Basis zu ermöglichen, wurde zudem nach konstitutiv exprimierten miRNAs („Housekeepern“) zur Datennormalisierung gesucht, die in einem septischen Milieu unverändert exprimiert werden. Hierfür wurde ein Zellkulturmodell (murine Makrophagen RAW264.7; humane Endothelzellen TIME) mit LPS, Zytokinen und Fettsäuren stimuliert. Aufgrund ihrer Stabilität eignen sich als Housekeeper insbesondere miR-151a-5p (TIME) sowie miR-27b-3p und miR-103a-3p (RAW 264.7).
description: In this thesis, the suitability of miRNAs as biomarkers for sepsis was investigated and compared with established diagnostic parameters. For this purpose, blood samples from septic and non-septic intensive care patients as well as healthy blood donors were analyzed. No miRNA with optimal properties for diagnostic use could be identified. Nevertheless, it was shown that integration of miRNAs into scoring systems can improve their diagnostic significance. In addition, to enable subsequent qRT-PCR-based studies, we searched for constitutively expressed miRNAs ("housekeepers") for data normalization that are constantly expressed in a septic environment. For this purpose, a cell culture model (murine macrophages RAW264.7; human endothelial cells TIME) was stimulated with LPS, cytokines, and fatty acids. Due to their stability, miR-151a-5p (TIME) as well as miR-27b-3p and miR-103a-3p (RAW 264.7) are particularly suitable as housekeepers.
Morita classes of microdifferential algebroids
Creators: name: D'Agnolo, Andrea
name: Polesello, Pietro
Publisher: name: arXiv
Year: 2011
Subjects: subject: Algebraic Geometry (math.AG)
subject: Quantum Algebra (math.QA)
subject: FOS: Mathematics
subject: 58J15, 53C56, 32C38

description: Projective cotangent bundles of complex manifolds are the local models of complex contact manifolds. Such bundles are quantized by the algebra of microdifferential operators (a localization of the algebra of differential operators on the base manifold). Kashiwara proved that any complex contact manifold $X$ is quantized by a canonical microdifferential algebroid (a linear stack locally equivalent to an algebra of microdifferential operators). Besides the canonical one, there can be other microdifferential algebroids on $X$. Our aim is to classify them. More precisely, let $Y$ be the symplectification of $X$. We prove that Morita (resp. equivalence) classes of microdifferential algebroids on $X$ are described by $H^2(Y;{\mathbb C}^\times)$. We also show that any linear stack locally equivalent to a stack of microdifferential modules is in fact a stack of modules over a microdifferential algebroid. To obtain these results we use techniques of microlocal calculus, non-abelian cohomology and Morita theory for linear stacks.
description: Final version appeared in Publ. Res. Inst. Math. Sci., 42 pages
Covalency, double-counting and the metal-insulator phase diagram in transition metal oxides
Creators: name: Wang, Xin
name: Han, M. J.
name: Medici, Luca de'
name: Park, Hyowon
name: Marianetti, C. A.
name: Millis, Andrew J.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Dynamical mean field theory calculations are used to show that for late transition-metal-oxides a critical variable for the Mott/charge-transfer transition is the number of d-electrons, which is determined by charge transfer from oxygen ions. Insulating behavior is found only for a narrow range of d-occupancy, irrespective of the size of the intra-d Coulomb repulsion. The result is useful in interpreting 'density functional +U' and 'density functional plus dynamical mean field' methods in which additional correlations are applied to a specific set of orbitals and an important role is played by the 'double counting correction' which dictates the occupancy of these correlated orbitals. General considerations are presented and are illustrated by calculations for two representative transition metal oxide systems: layered perovskite Cu-based "high-Tc" materials, an orbitally non-degenerate electronically quasi-two dimensional systems, and pseudocubic rare earch nickelates, an orbitally degenerate electronically three dimensional system. Density functional calculations yield d-occupancies very far from the Mott metal-insulator phase boundary in the nickelate materials, but closer to it in the cuprates, indicating the sensitivity of theoretical models of the cuprates to the choice of double counting correction and corroborating the critical role of lattice distortions in attaining the experimentally observed insulating phase in the nickelates.
description: 10+ pages, 5 figures
Weak charge form factor and radius of 208Pb through parity violation in electron scattering
Creators: name: Horowitz, C. J.
name: Ahmed, Z.
name: Jen, C. -M.
name: Rakhman, A.
name: Souder, P. A.
name: Dalton, M. M.
name: Liyanage, N.
name: Paschke, K. D.
name: Saenboonruang, K.
name: Silwal, R.
name: Franklin, G. B.
name: Friend, M.
name: Quinn, B.
name: Kumar, K. S.
name: Mammei, J. M.
name: McNulty, D.
name: Mercado, L.
name: Riordan, S.
name: Wexler, J.
name: Michaels, R. W.
name: Urciuoli, G. M.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We use distorted wave electron scattering calculations to extract the weak charge form factor F_W(q), the weak charge radius R_W, and the point neutron radius R_n, of 208Pb from the PREX parity violating asymmetry measurement. The form factor is the Fourier transform of the weak charge density at the average momentum transfer q=0.475 fm$^{-1}$. We find F_W(q) =0.204 \pm 0.028 (exp) \pm 0.001 (model). We use the Helm model to infer the weak radius from F_W(q). We find R_W= 5.826 \pm 0.181 (exp) \pm 0.027 (model) fm. Here the exp error includes PREX statistical and systematic errors, while the model error describes the uncertainty in R_W from uncertainties in the surface thickness σof the weak charge density. The weak radius is larger than the charge radius, implying a "weak charge skin" where the surface region is relatively enriched in weak charges compared to (electromagnetic) charges. We extract the point neutron radius R_n=5.751 \pm 0.175 (exp) \pm 0.026 (model) \pm 0.005 (strange) fm$, from R_W. Here there is only a very small error (strange) from possible strange quark contributions. We find R_n to be slightly smaller than R_W because of the nucleon's size. Finally, we find a neutron skin thickness of R_n-R_p=0.302\pm 0.175 (exp) \pm 0.026 (model) \pm 0.005 (strange) fm, where R_p is the point proton radius.
description: 5 pages, 1 figure, published in Phys Rev. C. Only one change in this version: we have added one author, also to metadata
State rescaling, experimental reforms and institutional continuity : the shifting spatial logics of socioeconomic regulation in post-1949 China
Creators: name: Lim, Kean Fan
Publisher: name: University of British Columbia
Year: 2014

description: Drawing on the literature on state rescaling, this dissertation investigates how post-1978 layers of policy shifts interact with regulatory logics of Mao Zedong-era policies, and in turn how this reproduces what the Chinese state now deems to be ‘necessary’ forms of uneven development. It proceeds on the premise that the shifting regulatory geographies of the Chinese state constitute a prism through which to evaluate socioeconomic change in China. The analysis is presented in two parts. First, it questions the logics and implications of designating specific territories – Hengqin and Qianhai in the Pearl River Delta and Liangjiang in Chongqing – into “nationally strategic new areas” after the 2008 global financial crisis. These logics were assessed through triangulating three primary empirical sources: policy documents, published comments by state actors and interviews with planners and scholars in China. The contemporary cases are presented in two segments, each comprising two chapters (Chapters 6 to 9). The first chapter of each segment explores how the geo-historical context and key actors enabled the national designation, the second examines the implications of key policy experimentation in the areas. Working from these empirical findings, the dissertation revisited historical sources (memoirs from different state actors of the Mao era, statistics extending back to 1949, academic articles in China, etc.) and developed a geographical-historical narrative that evaluates how the spatial logics of socioeconomic regulation have evolved during and after the Mao era (Chapters 4 and 5). The outcome is a two-pronged, mutually-reinforcing attempt to theorize the past from the lens of the present, and to conceptualize the present through ascertaining the impacts of policies inherited from past regimes. In so doing, the dissertation problematizes simple ‘transition’ models that portray a unidirectional, epochal change in the post-1978 Chinese political economy, a change characterized by decentralized governance and intensified economic-geographical inequality. It emphasizes, instead, a more deeply sedimented pattern of development that is marked simultaneously by significant (and enduring) forms of uneven socioeconomic development and experimental (and capricious) attempts to transcend these forms.
Supporting science pre-service elementary teachers in learning to plan modeling-based investigations
Creators: name: Téllez-Acosta, María Esther
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 370

description: Bei der aktuellen Dissertationsarbeit handelt es sich um eine „Design-Based Research“ (DBR)-Forschungsarbeit mit zwei iterativen Zyklen. Sie zielt darauf ab, didaktische Unterstützungen und die damit verbundenen pädagogischen Werkzeuge zu entwerfen, zu implementieren und zu analysieren. Dies soll angehende Sachunterrichtsstudierende beim Lernen unterstützen, um modellbasierte Untersuchungen (MBUs) zu planen. „Professional Vision“ (PV, Goodwin, 1994) wird als theoretischer und analytischer Rahmen verwendet. Die Ergebnisse und Beiträge sind in drei Manuskripten konsolidiert. Manuskript I betont, dass das biologiespezifische epistemische Werkzeug (Transformationsboxen, TBs) in dem Design, die Flexibilität im Umgang mit disziplinären Kernideen und wissenschaftlichen Modellierung fördert (d.h. epistemische Aushandlung). Dieses TBs Tool eröffnet auch Möglichkeiten zur Strukturierung der MBUs (d.h. pädagogische Aushandlung). Manuskript I betont, dass eine zielgerichtete Kombination von webbasierten Ressourcen in ILIAS ® die Diskussion und die Partizipation bei jeder der vorgeschlagenen Aufgaben verbessert. Manuskript III trägt dazu bei, den Wert der Bemühungen einer soziokulturellen Perspektive des Lernens für die Lehrer*innenbildung zu erkennen und zu erweitern.
description: The current dissertation work is two-iterative-cycle Design-based Research (DBR). It aims to design, implement, and analyze pedagogies and their associated pedagogical tools to support pre-service elementary teachers in learning to plan modeling-based investigations (MBIs). Professional vision (PV, Goodwin, 1994) is used as the theoretical and analytical framework. The results and contribution are consolidated in three manuscripts. Manuscript I suggests that the biology-specific epistemic tool (Transformation Boxes, TBs) embedded in the design fostered pre-service teachers' flexibility in dealing with disciplinary core ideas and scientific modeling (i.e., epistemic negotiation). This TBs tool also opened possibilities for structuring MBIs (i.e., pedagogical negotiation). Manuscript II suggests that a goal-oriented combination of web-based resources in the learning management system ILIAS ® enhanced pre-service teachers' discussion and participation in each of the proposed tasks. Manuscript III contributes to recognizing the value of conceptualizing PV from a sociocultural perspective of learning to expand teacher education efforts.
Epigenetic changes in preimplantation embryos from a diabetic pregnancies
Creators: name: Grybel, Katarzyna Joanna
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: 610

description: Unsere Hypothese ist, dass durch Diabetes induzierten Veränderungen im uterinen Milieu zu einer Verzögerung in der Embryonalenentwicklung führenund dass die Entwicklungsverzögerung durch DNA-Methylierungstörungen an spezifischen Genpromotoren bedingt sein können. Zuerst haben wir Bildung der ersten embryonalen Zelllinien, Epi-, Hypo- und Trophoblast in Embryonen von diabetischen Kaninchen untersucht. Das Epiblast spezifische Oct4 mit Pluripotenzgenen Sox2 und Nanog, war im Epiblast erhöht. Die Hypoblastmarker Cer1 und Dkk1 waren herunterreguliert. Danach haben wir die Verteilung der DNA-Methylierung in den funktionalen Elementen des Promotors für das Oct4 mittels Bisulfit-Seq analysiert. Wir konnten eine Hypomethylierung des Hypoblasts in den Embryonen von diabetischen Kaninchen finden. Wir schlussfolgern, dass die Entwicklungsverzögerung in Embryonen von diabetischen Kaninchen auf den Erhalt der Pluripotenz im Epi- und verlangsamerter Differenzierung des Hypoblasten zurückzuführen sind.
description: A diabetic pregnancy has consequences on the health of the offspring, giving predispositions to metabolic syndrome, such diabetes type 2. We have hypothesized that changes in the uterine environment due to diabetes are related to the DNA methylation status at specific gene in the preimplantation embryo from diabetic rabbits. The observed delay in development to the formation of the first embryonic lineages: epiblast, hypoblast and trophoblast was reflected by upregulation of the epiblast lineage specifier Oct4 and pluripotency genes Sox2 and Nanog in epiblasts, and downregulation of the hypoblast markers Cer1 and Dkk1. The DNA methylation pattern of the Oct4 (POU5F1) promoter was investigated by bisulfite seq and hypomethylation of hypoblasts in embryo from diabetic rabbits was found. We conclude the delay in development in rabbit preimplantation embryos from diabetic pregnancies is manifested as retention of pluripotency in the epiblast and slower differentiation of the hypoblast.
La "malizia" della "universita' dei tiranni": chiamare "ribellione" il "resistere". Argomenti della comunicazione politica nel Seicento
Creators: name: De Benedictis, Angela
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2010
Subjects: M-STO/02 Storia moderna
IUS/19 Storia del diritto medievale e moderno
SPS/02 Storia delle dottrine politiche

description: Relazione presentata alla IX Giornata Luigi Firpo, Tirannide e dispotismo nel dibattito politico tra Cinque e Seicento, Torino 27-28 settembre 2002. Gli Atti della Giornata, a cura di Artemisio Enzo Baldini,  risultano in corso di preparazione nel catalogo dell’editore Olschki: http://www.olschki.it/cgi-bin/olscq2.pl?num=3794&lang=it, ISBN: 978 88 222 5739 0, Fondazione Luigi Firpo. Centro di studi sul pensiero politico - Studi e testi, vol. 28. Consegnato al curatore nell’agosto 2003, dall’aprile  2006 il presente saggio si trova nello stato di I bozza per la stampa. 
Il saggio analizza linguaggio politico e discorso politico di un pamphlet che fu parte della rivolta catalana del 1640, e che ora da qualche anno lo è anche della sua storiografia, essendo stato pubblicato in una collana dedicata agli scritti politici catalani del XVII secolo. Si tratta della Noticia Universal de Cataluña scritta dal giurista Francesc Martí Viladamor, e datata 21 dicembre 1640.
Dato il contesto, ovvero il «linguaggio politico delle rivoluzioni», il saggio propone di riconsiderare la problematica storiografica «rivolte e rivoluzioni» in età moderna a partire dal recupero del tema «tirannide».
Stability of Reeb Graphs under function perturbations: the case of closed curves
Creators: name: Di Fabio, Barbara
name: Landi, Claudia
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2010

description: Reeb graphs provide a method for studying the shape of a manifold by encoding
the evolution and arrangement of level sets of a simple Morse function defined on
the manifold. Since their introduction in computer graphics they have been gaining popularity
as an effective tool for shape analysis and matching. In this context one question
deserving attention is whether Reeb graphs are robust against function perturbations. Focusing
on 1-dimensional manifolds, we define an editing distance between Reeb graphs of
curves, in terms of the cost necessary to transform one graph into another. Our main result
is that changes in Morse functions induce smaller changes in the editing distance between
Reeb graphs of curves, implying stability of Reeb graphs under function perturbations.
Einfluss des akuten Nierenversagens auf eine vorbestehende orale Antikoagulation mit Vitamin-K-Antagonisten
Creators: name: Süfling, Luisa Catrice
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 610

description: Obwohl Vitamin-K-Antagonisten (VKA) hauptsächlich hepatisch metabolisiert werden, wurde in Einzelfällen beobachtet, dass die International Normalized Ratio (INR) bei Patienten mit VKA während einer akuten Nierenschädigung (AKI) ansteigt. Diese retrospektive Arbeit ist die erste systemische Studie, die den Zusammenhang zwischen Auftreten eines AKI und Überantikoagulation bei Patienten mit vorbestehender Therapie mit VKA untersucht. Eingeschlossen wurden 100 Patienten, die zwischen 2009 und 2016 in der Innere Medizin II der Martin-Luther-Universitätsklinik in Halle stationär waren, ein AKI erlitten und VKA erhielten. Die INR-Werte während des AKI erwiesen sich höher als zum Referenzzeitpunkt (Median 3,17 vs. 2,24; p < 0,0001). Patienten mit Diabetes mellitus (p = 0,013), Frauen (p = 0,018) und Patienten mit einem BMI von maximal 25 kg/m2 (p = 0,049) waren für eine Überantikoagulation während des AKI prädisponiert. Bei 24 Patienten traten Blutungen auf, 9 erhielten eine Bluttransfusion.
description: Although vitamin K antagonists (VKA) are mainly metabolized by the liver, in isolated cases it has been observed that the International Normalised Ratio (INR) increases in patients with ongoing VKA therapy during acute kidney injury (AKI). This retrospective study is the first systematic trial to investigate the association between the occurrence of AKI and overanticoagulation in patients under permanent anticoagulation therapy with VKA. It included 100 patients who were admitted to the Department of Internal Medicine II of the Martin Luther University Hospital Halle between 2009 und 2016, suffering an AKI and receiving VKA. The average INR values were higher at the time of AKI than at the reference time point (median 3.17 vs. 2.24; p < 0.0001). Patients with diabetes mellitus (p=0.013), women (p=0.018), and patients with a BMI of 25 kg/m2 or less (p=0.049) were predisposed to overanticoagulation during AKI. Bleeding occurred in 24 patients, 9 received a blood transfusion.
Additional file 1 of Genome-wide analysis of Myo-inositol oxygenase gene family in tomato reveals their involvement in ascorbic acid accumulation
Creators: name: Munir, Shoaib
name: Mumtaz, Muhammad Ali
name: Ahiakpa, John Kojo
name: Liu, Genzhong
name: Chen, Weifang
name: Zhou, Guolin
name: Zheng, Wei
name: Ye, Zhibiao
name: Zhang, Yuyang
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 1 Table S1. List of primer sequences. Fig. S1. Phylogenetic analysis of 5 MIOX proteins from S. lycopersicum with other species MIOX proteins. Fig. S2. Alignment of 5 MIOX protein sequence from S. lycopersicum. Multiple sequence alignments were conducted using ClustalW2. Fig. S3. Chromosomal distribution of the SlMIOX genes. A total of 5 SlMIOX genes were mapped onto tomato chromosomes. The gene identity numbers are provided, and respective chromosome numbers are shown at the top.
Proceedings of 2011 Kentucky Water Resources Annual Symposium
Creators: name: Kentucky Water Resources Research Institute, University Of Kentucky
Publisher: name: Kentucky Water Resources Research Institute, University of Kentucky
Year: 2011

description: This conference was planned and conducted as part of the state water resources research annual program with the support and collaboration of the Department of the Interior, U.S. Geological Survey and the University of Kentucky Research Foundation, under Grant Agreement Number 06HQGR0087.
The views and conclusions contained in this document and presented at the symposium are those of the abstract authors and presenters and should not be interpreted as necessarily representing the official policies, either expressed or implied, of the U.S. Government or other symposium organizers and sponsors.
Parents as partners : perspectives of school supports in parents of adolescents with internalizing disorders
Creators: name: Carter, Alexandra
Publisher: name: University of British Columbia
Year: 2014

description: The purpose of this study was to identify, describe, and categorize the experiences of child and family school supports in parents of adolescents with internalizing mental health concerns. Few studies have asked parents about their experiences with their child’s school, particularly in relation to their child’s mental health needs. Furthermore, the needs and involvement of parents of youth with internalizing disorders have not been examined specifically at the secondary school level, where academic and other school-related requirements may differ from elementary school. This research was conducted to add to the limited literature in understanding the school-based needs of parents of youth with internalizing disorders. Eleven parents of adolescents diagnosed with an internalizing disorder were interviewed and asked about aspects of school support that they perceived as being helpful or hindering to their child or family. Data were analyzed using the enhanced critical incident technique (ECIT; Butterfield, Borgen, Maglio, & Amundson, 2009), which has been adapted from Flanagan’s (1954) critical incident technique (CIT). Critical events (n=215) were recorded and sorted into emergent unitary clusters based on content analysis. These categories were subjected to rigorous reliability and validity checks including analysis by another researcher, calculation of interrater agreement, and participant feedback. This process yielded seven categories that represented the participants’ experiences of school support. The categories were: Individualized Support, Communication Between Home and School, Understanding and Support, a Team Approach, A Safe Place at School, Having an Advocate in the School System, and Understanding Mental Health. Participants were asked to generate a wish list of supports they would find helpful if available. Thirty-one wish list items were generated by eight of the participants. Wish list items embodied four categories, which were: Counselling and Learning Supports, Resources and Services, Communication, and Professional Development.
Decomposition of homogeneous polynomials over an algebraically closed field.
Creators: name: Ballico, Edoardo
name: Bernardi, Alessandra
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2010
Subjects: MAT/03 Geometria

description: Let $F$ be a homogeneous polynomial of degree $d$ in $m+1$ variables defined over an algebraically closed field of characteristic zero and suppose that $F$ belongs to the $s$-th secant varieties of the standard Veronese variety $X_{m,d}\subset \mathbb{P}^{{m+d\choose d}-1}$ but that its minimal decomposition as sum of $d$-th powers of linear forms $M_1, \ldots , M_r$ is $F=M_1^d+\cdots + M_r^d$ with $r>s$. We show that if $s+r\leq 2d+1$ then such a decomposition of $F$ can be split in two parts:  one of them is uniquely determined by linear forms that can be written using only two variables, the other part is algorithmically computable. We also show that the $0$-dimensional scheme $\mathcal{Z}$ of degree $s$ that is contained in $X_{m,d}$ and such that $F\in \langle \mathcal{Z}\rangle$ is uniquely determined by $F$ itself.
Injectivity of satellite operators in knot concordance
Creators: name: Cochran, Tim D.
name: Davis, Christopher W.
name: Ray, Arunima
Publisher: name: arXiv
Year: 2012
Subjects: subject: Geometric Topology (math.GT)
subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics
subject: 57M25 (Primary)

description: Let P be a knot in a solid torus, K a knot in 3-space and P(K) the satellite knot of K with pattern P. This defines an operator on the set of knot types and induces a satellite operator P:C--> C on the set of smooth concordance classes of knots. There has been considerable interest in whether certain such functions are injective. For example, it is a famous open problem whether the Whitehead double operator is weakly injective (an operator is called weakly injective if P(K)=P(0) implies K=0 where 0 is the class of the trivial knot). We prove that, modulo the smooth 4-dimensional Poincare Conjecture, any strong winding number one satellite operator is injective on C. More precisely, if P has strong winding number one and P(K)=P(J), then K is smoothly concordant to J in S^3 x [0,1] equipped with a possibly exotic smooth structure. We also prove that any strong winding number one operator is injective on the topological knot concordance group. If P(0) is unknotted then strong winding number one is the same as (ordinary) winding number one. More generally we show that any satellite operator with non-zero winding number n induces an injective function on the set of Z[1/n]-concordance classes of knots. We extend some of our results to links.
description: 16 pages; in second version we have added some results on operators on links and string links and added some references to connections with Mazur manifolds and corks; third version has only very minor changes and will appear in Journal of Topology
Feste Delfiche (1927 e 1930). Fotografie dagli Archivi Storici del Museo Benaki di Atene
Creators: name: Zaccarini, Matteo
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2009
Subjects: L-FIL-LET/02 Lingua e letteratura greca
L-LIN/20 Lingua e letteratura neogreca
L-ART/05 Discipline dello spettacolo
L-ANT/07 Archeologia classica

description: Le Feste Delfiche, opera visionaria ideata e realizzata dal poeta greco Angelos Sikelianos e dalla moglie statunitense Eva Palmer, videro la luce in due edizioni nel 1927 e nel 1930. Ispirate alla cultura greca classica e a ideali di comunione intellettuale e spirituale, le Feste costituirono un tentativo unico, straordinariamente moderno nella sua concezione, di ristabilire e ripensare un legame tra il passato e il presente. La mostra fotografica "Fotografie di antichità classiche dagli archivi del Museo Benaki di Atene (1880-1960)" (Ravenna, Palazzo dei Congressi, 18-30.V.2009 e Atene, College Year in Athens, 18.IV-13.V.2010) ha portato agli occhi del pubblico una selezione di fotografie d'epoca originali e inedite relative alle Feste, tratte dagli Archivi Storici del Museo Benaki di Atene. 


The Delphic festivals, a visionary idea created by the Greek poet Angelos Sikelianos and his American wife Eva Palmer, were realized in two editions in 1927 and 1930. Inspired by classical Greek culture and ideals of intellectual and spiritual communion, the Festivals represent a unique attempt, remarkably modern in its conception, to re-establish and re-think a link between past and present. The photographic exhibition "Photographs of Classical Antiquities from the Archives of the Benaki Museum in Athens (1880-1930)" (Ravenna, Palazzo dei Congressi, 18-30.V.2009 and Athens, College Year in Athens, 18.IV-13.V.2010) brings to the public a selection of original and unpublished photographs of the Festivals, drawn by the Historical Archives of the Benaki Museum in Athens.
Utility maximization with addictive consumption habit formation in incomplete semimartingale markets
Creators: name: Yu, Xiang
Publisher: name: arXiv
Year: 2011
Subjects: subject: Portfolio Management (q-fin.PM)
subject: Optimization and Control (math.OC)
subject: Probability (math.PR)
subject: FOS: Economics and business
subject: FOS: Mathematics

description: This paper studies the continuous time utility maximization problem on consumption with addictive habit formation in incomplete semimartingale markets. Introducing the set of auxiliary state processes and the modified dual space, we embed our original problem into a time-separable utility maximization problem with a shadow random endowment on the product space $\mathbb{L}_+^0(Ω\times [0,T],\mathcal{O},\overline{\mathbb{P}})$. Existence and uniqueness of the optimal solution are established using convex duality approach, where the primal value function is defined on two variables, that is, the initial wealth and the initial standard of living. We also provide sufficient conditions on the stochastic discounting processes and on the utility function for the well-posedness of the original optimization problem. Under the same assumptions, classical proofs in the approach of convex duality analysis can be modified when the auxiliary dual process is not necessarily integrable.
description: Published at http://dx.doi.org/10.1214/14-AAP1026 in the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org)
CLS INFRA D2.1 Communication and Dissemination Plan
Creators: name: Murphy, Ciara L.
name: Tonra, Justin
Publisher: name: Zenodo
Year: 2021
Subjects: research communication
research dissemination
research exploitation
computational literary studies

description: D 2.1: Initial plan for communication and dissemination of project results and RI access, including audience/instrument mapping and communications KPIs (M6, to be updated continuously from then on until M 48).