cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
So depression is an inflammatory disease, but where does the inflammation come from?
Creators: name: Berk, Michael
name: Williams, Lana J.
name: Jacka, Felice N.
name: O'Neil, Adrienne
name: Pasco, Julie A.
name: Moylan, Steven
name: Allen, Nicholas B.
name: Stuart, Amanda L.
name: Hayley, Amie
name: Byrne, Michelle L.
name: Maes, Michael
Publisher: name: Swinburne
Year: 2024

description: Background: We now know that depression is associated with a chronic, low-grade inflammatory response and activation of cell-mediated immunity, as well as activation of the compensatory anti-inflammatory reflex system. It is similarly accompanied by increased oxidative and nitrosative stress (O&NS), which contribute to neuroprogression in the disorder. The obvious question this poses is 'what is the source of this chronic low-grade inflammation?'. Discussion: This review explores the role of inflammation and oxidative and nitrosative stress as possible mediators of known environmental risk factors in depression, and discusses potential implications of these findings. A range of factors appear to increase the risk for the development of depression, and seem to be associated with systemic inflammation; these include psychosocial stressors, poor diet, physical inactivity, obesity, smoking, altered gut permeability, atopy, dental cares, sleep and vitamin D deficiency.Summary: The identification of known sources of inflammation provides support for inflammation as a mediating pathway to both risk and neuroprogression in depression. Critically, most of these factors are plastic, and potentially amenable to therapeutic and preventative interventions. Most, but not all, of the above mentioned sources of inflammation may play a role in other psychiatric disorders, such as bipolar disorder, schizophrenia, autism and post-traumatic stress disorder.
Identifying the reciprocal causation between hit-and-run behavior and crash injury severity
Creators: name: Zhang, Guopeng
name: Xuan, Qianwei
name: Cai, Ying
name: Hu, Xianghong
name: Hu, Nianyi
name: Jiang, Xinguo
name: Yao, Xinkun
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Hit-and-run behavior is believed to exacerbate the injury severity of traffic crashes due to the delayed emergency response for the victims. However, several previous studies indicated the opposite finding that hit-and-run crashes were associated with less severe injuries. The relevant studies mainly identified the statistical associations between hit-and-run behavior and injury severity without revealing causation between them. To this end, the study aims to explore the reciprocal causation between the two variables. The two-stage probit model with endogenous regressors is employed to identify the reciprocal causation between hit-and-run behavior and crash injury severity for single- and two-vehicle crashes, respectively, with the use of crash data extracted from the Crash Report Sampling System and Fatality Analysis Reporting System (2016-2019). The results indicate that 1) for both single- and two-vehicle crashes, the fleeing behavior can significantly increase the injury severity of the victims in the crashes while the severe injury of the victims has a negative impact on the propensity of such behavior, 2) the propensity of hit-and-run behavior is influenced by various instrumental variables such as driver age, gender, alcohol involvement, weekday, area type, and light condition, and 3) crash injury severity is significantly related to the victim age, gender, and vehicle damage. There is a reciprocal causation between hit-and-run behavior and injury severity in traffic crashes. The analytical results can provide a reasonable explanation for the counterintuitive finding on hit-an-run crashes and help mitigate the injury severity.
Prediction of traffic accident risk based on vehicle trajectory data
Creators: name: Li, Hao
name: Yu, Lina
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified

description: The objective of this study is to conduct precise risk prediction of traffic accidents using vehicle trajectory data. For urban road and highway scenarios, a scheme was developed to gather vehicle kinematic data and driving operation records from an in-vehicle device. The raw trajectory samples of over 3000 vehicles were processed through cleaning, filtering, interpolation, and normalization for preprocessing. Three deep learning frameworks based on RNN, CNN, and LSTM were compared. An end-to-end LSTM accident risk prediction model was constructed, and the model was trained using the cross-entropy loss function with Adam optimizer. The LSTM model is capable of directly extracting accident-related hazardous state features from low-quality raw trajectory data, thereby enabling the prediction of accident probability with fine-grained time resolution. In tests conducted under complex traffic scenarios, the model successfully identifies high-risk driving behaviors in high-speed road sections and intersections with a prediction accuracy of 0.89, demonstrating strong generalization performance. The LSTM accident risk prediction model, based on vehicle trajectory, developed in this study, is capable of intelligently extracting dangerous driving features. It can accurately warn about the risk of traffic accidents and provides a novel approach to enhancing road safety.
title: Stop the pain
title: study protocol for a randomized-controlled trial
titleType: Subtitle
Creators: name: Warschburger, Petra
name: Calvano, Claudia
name: Becker, Sebastian
name: Friedt, Michael
name: Hudert, Christian
name: Posovszky, Carsten
name: Schier, Maike
name: Wegscheider, Karl
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Functional abdominal pain (FAP) is not only a highly prevalent disease but also poses a considerable burden on children and their families. Untreated, FAP is highly persistent until adulthood, also leading to an increased risk of psychiatric disorders. Intervention studies underscore the efficacy of cognitive behavioral treatment approaches but are limited in terms of sample size, long-term follow-up data, controls and inclusion of psychosocial outcome data. Methods/Design In a multicenter randomized controlled trial, 112 children aged 7 to 12 years who fulfill the Rome III criteria for FAP will be allocated to an established cognitive behavioral training program for children with FAP (n = 56) or to an active control group (focusing on age-appropriate information delivery; n = 56). Randomization occurs centrally, blockwise and is stratified by center. This study is performed in five pediatric gastroenterology outpatient departments. Observer- blind assessments of outcome variables take place four times: pre-, post-, 3- and 12-months post-treatment. Primary outcome is the course of pain intensity and frequency. Secondary endpoints are health-related quality of life, pain- related coping and cognitions, as well as selfefficacy. Discussion This confirmatory randomized controlled clinical trial evaluates the efficacy of a cognitive behavioral intervention for children with FAP. By applying an active control group, time and attention processes can be controlled, and long-term follow-up data over the course of one year can be explored.
Criteria for two-dimensional kinematics in an interacting Fermi gas
Creators: name: Dyke, Paul
name: Fenech, K.
name: Peppler, T.
name: Lingham, Marcus
name: Hoinka, Sascha
name: Zhang, Wanran
name: Peng, S. G.
name: Mulkerin, Brendan
name: Hu, Hui
name: Liu, Xiaji
name: Vale, Christopher
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 5108
subject: Quantum physics

description: Ultracold Fermi gases subject to tight transverse confinement offer a highly controllable setting to study the two-dimensional (2D) BCS to Berezinskii-Kosterlitz-Thouless superfluid crossover. Achieving the 2D regime requires confining particles to their transverse ground state which presents challenges in interacting systems. Here, we establish the conditions for an interacting Fermi gas to display 2D kinematics. Transverse excitations are detected by measuring the transverse expansion rate which displays a sudden increase when the atom number exceeds a critical value N2D signifying a density driven departure from 2D kinematics. For weak interactions N2D is set by the aspect ratio of the trap. Close to a Feshbach resonance, however, the stronger interactions reduce N2D and excitations appear at lower density.
title: MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients
title: A Potential Link to Skin Destruction and Metabolic Alterations
titleType: Subtitle
Creators: name: Tsaousi, Athanasia
name: Witte, Ellen
name: Witte, Katrin
name: Roewert-Huber, Hans-Joachim
name: Volk, Hans-Dieter
name: Sterry, Wolfram
name: Wolk, Kerstin
name: Schneider-Burrus, Sylke
name: Sabat, Robert
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Acne inversa (AI; also designated as hidradenitis suppurativa) is a chronic inflammatory disease with still unknown pathogenesis that affects the intertriginous skin of perianal, inguinal, and axillary sites. It leads to painful nodules, abscesses, and fistulas with malodorous secretion and is frequently associated with metabolic alterations. Here, we demonstrate that one of the most highly upregulated molecules in AI lesions is matrix metalloproteinase 8 (MMP8), an enzyme specialized in the degradation of extracellular matrix components and the HDL component apolipoprotein A-I. Granulocytes, which were present in AI lesions, secreted high amounts of MMP8 especially after TNF-α stimulation. Furthermore, activated fibroblasts but not keratinocytes were found to express MMP8. The high lesional MMP8 levels were accompanied by elevated blood levels that positively correlated with TNF-α blood levels and disease severity assessed by Sartorius score, especially with the number of regions with inflammatory nodules/abscesses and fistulas. Additionally, we found a negative correlation between blood MMP8 and HDL- cholesterol levels, suggesting a contributory role of MMP8 in metabolic alterations in AI. In summary, we demonstrate elevated MMP8 levels in AI lesions, suggest their role in skin destruction and metabolic alterations, and recommend the use of MMP8 as blood biomarker for AI disease activity assessment.
Global Overexpression of ET-1 Decreases Blood Pressure - A Systematic Review and Meta-Analysis of ET-1 Transgenic Mice
Creators: name: Lu, Yong Ping
name: Tsuprykov, Oleg
name: Vignon-Zellweger, Nicolas
name: Heiden, Susi
name: Hocher, Berthold
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: Heart weight
subject: Endothelin-1 transgenic mice
subject: Blood pressure
subject: Kidney weight
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background/Aims: ET-1 has independent effects on blood pressure regulation in vivo, it is involved in tubular water and salt excretion, promotes constriction of smooth muscle cells, modulates sympathetic nerve activity, and activates the liberation of nitric oxide. To determine the net effect of these partially counteracting mechanisms on blood pressure, a systematic meta- analysis was performed. Methods: Based on the principles of Cochrane systematic reviews, we searched in major literature databases - MEDLINE (PubMed), Embase, Google Scholar, and the China Biological Medicine Database (CBM-disc) - for articles relevant to the topic of the blood pressure phenotype of endothelin-1 transgenic (ET-1+/+) mice from January 1, 1988 to March 31, 2016. Review Manager Version 5.0 (Rev-Man 5.0) software was applied for statistical analysis. In total thirteen studies reported blood pressure data. Results: The meta-analysis of blood pressure data showed that homozygous ET-1 transgenic mice (ET-1+/+ mice) had a significantly lower blood pressure as compared to WT mice (mean difference: -2.57 mmHg, 95% CI: -4.98∼ -0.16, P = 0.04), with minimal heterogeneity (P = 0.86). A subgroup analysis of mice older than 6 months revealed that the blood pressure difference between ET-1+/+ mice and WT mice was even more pronounced (mean difference: -6.19 mmHg, 95% CI: -10.76∼ -1.62, P = 0.008), with minimal heterogeneity (P = 0.91). Conclusion: This meta-analysis provides robust evidence that global ET-1 overexpression in mice lowers blood pressure in an age-dependent manner. Older ET-1+/+ mice have a somewhat more pronounced reduction of blood pressure.
Telemedicine - a scientometric and density equalizing analysis
Creators: name: Groneberg, David A.
name: Rahimian, Shaghayegh
name: Bundschuh, Matthias
name: Schwarze, Mario
name: Gerber, Alexander
name: Kloft, Beatrix
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: Telemedicine
subject: Bibliometry
subject: Scientometry
subject: Density equalizing map
subject: Citation
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background As a result of the various telemedicine projects in the past years a large number of studies were recently published in this field. However, a precise bibliometric analysis of telemedicine publications does not exist so far. Methods The present study was conducted to establish a data base of the existing approaches. Density-equalizing algorithms were used and data was retrieved from the Thomson Reuters database Web of Science. Results During the period from 1900 to 2006 a number of 3290 filed items were connected to telemedicine, with the first being published in 1964. The studies originate from 101 countries, with the USA, Great Britain and Canada being the most productive suppliers participating in 56.08 % of all published items. Analyzing the average citation per item for countries with more than 10 publications, Ireland ranked first (10.19/item), New Zealand ranked second (9.5/item) followed by Finland (9.04/item). The citation rate can be assumed as an indicator for research quality. The ten most productive journals include three journals with the main focus telemedicine and another five with the main focus “Information/Informatics”. In all subject categories examined for published items related to telemedicine, “Health Care Sciences & Services” ranked first by far. More than 36 % of all publications are assigned to this category, followed by “Medical Informatics” with 9.72 % and “Medicine, General & Internal” with 8.84 % of all publications. Conclusion In summary it can be concluded that the data shows clearly a strong increase in research productivity. Using science citation analysis it can be assumed that there is a large rise in the interest in telemedicine studies.
Evidence for the presence of large-scale deletion mutations in a murine tumour model.
Creators: name: Weppler, Sherry Anne.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Biology, Molecular.

description: In order to study mutagenicity occurring within a tumour environment, our lab has developed the Mutated murine tumour model, which is able to sensitively detect mutations at a genetically manipulated hprt locus. Prior to my work, the X-linked hprt gene in the Mutated cell lines was thought to be heterozygous based on high sensitivity to induction of mutations by ionizing radiation and the identification of 3 X-chromosomes by fluorescent in situ hybridization. In order to determine the hprt genotype and to confirm that the hprt gene was indeed heterozygous, the hprt cDNA of Mutated cells was cloned and sequenced. Three mRNA species were identified: mRNA-A corresponds to wild type hprt, mRNA-B contains a single nucleotide deletion within exon 3, and mRNA-C contains a deletion of exons 2 and 3. In order to identify the types of mutations that are generated during in vivo tumour growth, a screening method was devised to analyze mutations occurring in the wild type hprt gene. (Abstract shortened by UMI.)
Robust Adaptation Research in High Mountains: Integrating the Scientific, Social, and Ecological Dimensions of Glacio-Hydrological Change
Creators: name: McDowell, Graham
name: Koppes, Michele
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Climate-related changes in glacierized watersheds are widely documented, stimulating adaptive responses among the 370 million people living in glacier-influenced watersheds as well as aquatic and riparian ecosystems. The situation denotes important interdependencies between science, society, and ecosystems, yet integrative approaches to the study of adaptation to such changes remain scarce in both the mountain- and non-mountain-focused adaptation scholarship. Using the example of glacio-hydrological change, it is argued here that this analytical limitation impedes the identification, development, and implementation of “successful” adaptations. In response, the paper introduces three guiding principles for robust adaptation research in glaciated mountain regions. Principle 1: Adaptation research should integrate detailed analyses of watershed-specific glaciological and hydro-meteorological conditions; glacio-hydrological changes are context-specific and therefore cannot be assumed to follow idealized trajectories of “peak water”. Principle 2: Adaptation research should consider the complex interplay between glacio-hydrological changes and socio-economic, cultural, and political conditions; responses to environmental changes are non-deterministic and therefore not deducible from hydrological changes alone. Principle 3: Adaptation research should be attentive to interdependencies, feedbacks, and tradeoffs between human and ecological responses to glacio-hydrological change; research that does not evaluate these socio-ecological dynamics may lead to maladaptive adaptation plans. These principles call attention to the linked scientific, social, and ecological dimensions of adaptation, and offer a point of departure for future climate change adaptation research in high mountains.
Validation of a generic finite element vehicle buck model for near-side crashes
Creators: name: Costa, Casey G.
name: Devane, Karan
name: Stitzel, Joel D.
name: Iraeus, Johan
name: Weaver, Ashley A.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: Finite element (FE) reconstructions of motor vehicle crashes using human body models are effective tools for developing a better understanding of occupant kinematics and injuries in real-world lateral crash conditions, but current near-side reconstruction methods are limited by the paucity of full-scale FE vehicle models. The objective of this study was to validate a generic vehicle model equipped with left-side airbags and intrusion capability by simulating a series of near-side crash tests for a range of vehicles and assessing model accuracy using objective evaluation methods. Moving deformable barrier crash tests were reconstructed for five common vehicle classifications (compact passenger, mid-size passenger, sport utility vehicle, pickup truck, and van) using an updated version of a previously developed simplified vehicle model. Unknown vehicle and intrusion properties (pretensioner force, seatback airbag pressure, curtain airbag pressure, door panel stiffness, ratio of dynamic-to-static intrusion, intrusion velocity, and intrusion scaling factor) were estimated by parameterizing them across 224 simulations per crash test using a Latin hypercube design of experiments. Model accuracy was assessed for 13 anthropomorphic test device signals using the Correlation and Analysis (CORA) objective rating method and injury metric comparisons. Maximum ratings of 0.69, 0.67, 0.52, 0.52, and 0.62 were achieved for the compact passenger, midsize passenger, sport utility vehicle, pickup truck, and van classifications, respectively. On average, the abdomen displayed the most accurate behavior (0.51 ± 0.12), followed by the thorax (0.50 ± 0.10) and head (0.50 ± 0.07). The pelvis displayed the least accurate behavior (0.46 ± 0.18) of any region. Reconstructions overpraedicted injury metrics in all cases. All vehicles achieved “fair” biofidelity ratings and the compact passenger and midsize passenger vehicles achieved “good” biofidelity ratings, validating them for kinematic evaluations with vehicle-to-vehicle nearside crash reconstructions. Regression models were developed for injuries and CORA ratings and can be used to optimize vehicle parameters in future studies.
Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy
Creators: name: Heinig, Matthias
name: Adriaens, Michiel E.
name: Schafer, Sebastian
name: Deutekom, Hanneke W. M. Van
name: Lodder, Elisabeth M.
name: Ware, James S.
name: Schneider, Valentin
name: Felkin, Leanne E.
name: Creemers, Esther E.
name: Meder, Benjamin
name: Katus, Hugo A.
name: Ruehle, Frank
name: Stoll, Monika
name: Cambien, Francois
name: Villard, Eric
name: Charron, Philippe
name: Varro, Andras
name: Bishopric, Nanette H.
name: George, Alfred L.
name: Remedios, Cristobal Dos
name: Moreno-Moral, Aida
name: Pesce, Francesco
name: Bauerfeind, Anja
name: Rueschendorf, Franz
name: Rintisch, Carola
name: Petretto, Enrico
name: Barton, Paul J.
name: Cook, Stuart A.
name: Pinto, Yigal M.
name: Bezzina, Connie R.
name: Hubner, Norbert
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Gene expression
subject: eQTL
subject: Dilated cardiomyopathy
subject: Heart
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::576 Genetik und Evolution
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background: Genetic variation is an important determinant of RNA transcription and splicing, which in turn contributes to variation in human traits, including cardiovascular diseases. Results: Here we report the first in-depth survey of heart transcriptome variation using RNA-sequencing in 97 patients with dilated cardiomyopathy and 108 non-diseased controls. We reveal extensive differences of gene expression and splicing between dilated cardiomyopathy patients and controls, affecting known as well as novel dilated cardiomyopathy genes. Moreover, we show a widespread effect of genetic variation on the regulation of transcription, isoform usage, and allele-specific expression. Systematic annotation of genome-wide association SNPs identifies 60 functional candidate genes for heart phenotypes, representing 20% of all published heart genome-wide association loci. Focusing on the dilated cardiomyopathy phenotype we found that eQTL variants are also enriched for dilated cardiomyopathy genome-wide association signals in two independent cohorts. Conclusions: RNA transcription, splicing, and allele-specific expression are each important determinants of the dilated cardiomyopathy phenotype and are controlled by genetic factors. Our results represent a powerful resource for the field of cardiovascular genetics.
Healthy Living after Cancer: A dissemination and implementation study evaluating a telephone-delivered healthy lifestyle program for cancer survivors
Creators: name: Eakin, Elizabeth G.
name: Hayes, Sandra C.
name: Haas, Marion R.
name: Reeves, Marina M.
name: Vardy, Janette L.
name: Boyle, Frances
name: Hiller, Janet
name: Mishra, Gita D.
name: Goode, Ana D.
name: Jefford, Michael
name: Koczwara, Bogda
name: Saunders, Christobel M.
name: Demark-Wahnefried, Wendy
name: Courneya, Kerry S.
name: Schmitz, Kathryn H.
name: Girgis, Afaf
name: White, Kate
name: Chapman, Kathy
name: Boltong, Anna G.
name: Lane, Katherine
name: McKiernan, Sandy
name: Millar, Lesley
name: O'Brien, Lorna
name: Sharplin, Greg
name: Baldwin, Polly
name: Robson, Erin L.
Publisher: name: Swinburne
Year: 2024

description: BACKGROUND: Given evidence shows physical activity, a healthful diet and weight management can improve cancer outcomes and reduce chronic disease risk, the major cancer organisations and health authorities have endorsed related guidelines for cancer survivors. Despite these, and a growing evidence base on effective lifestyle interventions, there is limited uptake into survivorship care. METHODS/DESIGN: Healthy Living after Cancer (HLaC) is a national dissemination and implementation study that will evaluate the integration of an evidence-based lifestyle intervention for cancer survivors into an existing telephone cancer information and support service delivered by Australian state-based Cancer Councils. Eligible participants (adults having completed cancer treatment with curative intent) will receive 12 health coaching calls over 6 months from Cancer Council nurses/allied health professionals targeting national guidelines for physical activity, healthy eating and weight control. Using the RE-AIM evaluation framework, primary outcomes are service-level indicators of program reach, adoption, implementation/costs and maintenance, with secondary (effectiveness) outcomes of patient-reported anthropometric, behavioural and psychosocial variables collected at pre- and post-program completion. The total participant accrual target across four participating Cancer Councils is 900 over 3 years. DISCUSSION: The national scope of the project and broad inclusion of cancer survivors, alongside evaluation of service-level indicators, associated costs and patient-reported outcomes, will provide the necessary practice-based evidence needed to inform future allocation of resources to support healthy living among cancer survivors. TRIAL REGISTRATION: Australian and New Zealand Clinical Trials Registry (ANZCTR) - ACTRN12615000882527 (registered on 24/08/2015).
title: Guidelines for conflict-sensitive adaptation to climate change
title: Guidelines for conflict-sensitive adaptation to climate change
titleType: AlternativeTitle
Creators: name: Tänzler, Dennis
name: Scherer, Nikolas
Publisher: name: Umweltbundesamt
Year: 2019
Subjects: subject: Anpassung an den Klimawandel
subject: Klimaänderung
subject: adaptation to climate change
subject: climate change
subject: conflict
subject: Climate | Energy

description: This guide outlines how to design and implement climate change adaptation projects in a fragile or conflict-affected context. It addresses planners and project managers and provides tools and methods to ensure that an adaptation project does not exacerbate tensions and, ideally, contributes to peace and stability. In three chapters, the guide provides a conceptual framework on conflict sensitivity and the relevance of climate change adaptation processes, a modular step-by-step guideline on how to integrate conflict sensitivity in an adaptation project, and an annex with supplementary information and tools to support the practical implementation of the guidelines. Quelle: https://www.umweltbundesamt.de
description: This guide outlines how to design and implement climate change adaptation projects in a fragile or conflict-affected context. It addresses planners and project managers and provides tools and methods to ensure that an adaptation project does not exacerbate tensions and, ideally, contributes to peace and stability. In three chapters, the guide provides a conceptual framework on conflict sensitivity and the relevance of climate change adaptation processes, a modular step-by-step guideline on how to integrate conflict sensitivity in an adaptation project, and an annex with supplementary information and tools to support the practical implementation of the guidelines.
Continuité et discontinuées dans le discours sur la modernité et ses malaises : une étude de Francis Fukuyama, Allan Bloom et Charles Taylor.
Creators: name: Hamon, Frédéric.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Sociology, Theory and Methods.

description: En cette fin de siecle, Allan Bloom, Charles Taylor et Francis Fukuyama s'interrogent sur la societe actuelle et s'interessent a son devenir. L'application large des principes democratiques (dignite, liberte et egalite) au sein des societes contemporaines produiront des changements fondmentaux dans tous les domaines significatifs de la vie. Mais malgre les bienfaits de cette nouvelle forme de vie, on constate certains malaises: relativisme, indifference, individualisme. La societe moderne est remise en question, et l'objectif principal de cette these est de reprendre l'analyse des auteurs susmentionnes sur la societe en vue de voir leur apport a sa remise en marche. Premierement, nous avons resume et presente les analyses de Bloom, Taylor et Fukuyama des malaises de la modernite. Deuxiemement, nous nous sommes interesse a l'analyse que Bloom, Taylor et Fukuyama font du sujet moderne. Troisiemement, nous avons procede a l'analyse de leur solution de rechange en vue de donner aux individus les moyens de rompre avec l'individualisme, le relativisme et l'indifference. Nous concluons avec l'idee suivant laquelle Francis Fukuyama avait propose l'analyse la mieux adaptee au besoin du sujet moderne.
Die Umweltprobenbank
Creators: name: Conrad, André
name: Kolossa-Gehring, Marike
name: Körner, Andrea
name: Koschorreck, Jan
name: Schröter-Kermani, Christa
name: Mohaupt, Volker
name: Rüther, Maria
name: Fliedner, Annette
name: Rüdel, Heinz
Publisher: name: My University
Year: 2016
Subjects: subject: Umweltprobenbank
subject: Umweltmonitoring
subject: Mensch
subject: Umwelt
subject: Chemische Analyse
subject: Chemikalienmanagement
subject: Internationale Beziehungen
subject: Datenspeicherung
subject: Umweltbeobachtung
subject: Datenarchivierung
subject: Gesundheit
subject: Health

description: Die Umweltprobenbank des Bundes (UPB) ist ein Archiv. Proben des Menschen und der Umwelt lagern dort bei sehr tiefen Temperaturen. Mit den regelmäßig gesammelten Proben können wir den Zustand unserer Umwelt dokumentieren und beobachten, wie sich die Belastung durch natürliche und anthropogene (Schad)Stoffe mit der Zeit verändert. Die Proben der UPB werden so gewonnen, transportiert, aufgearbeitet und gelagert, dass ihre biologische und chemische Information auch über lange Zeiträume konstant bleibt. Auf diese Weise machen es Umweltprobenbankenmöglich, dass wir aktuelle Proben mit Archivmaterial vergleichen können, das vor Jahrzehnten gesammelt und eingelagert wurde.Quelle: https://www.umweltbundesamt.de
description: Die Umweltprobenbank des Bundes (UPB) ist ein Archiv. Proben des Menschen und der Umwelt lagern dort bei sehr tiefen Temperaturen. Mit den regelmäßig gesammelten Proben können wir den Zustand unserer Umwelt dokumentieren und beobachten, wie sich die Belastung durch natürliche und anthropogene (Schad)Stoffe mit der Zeit verändert. Die Proben der UPB werden so gewonnen, transportiert, aufgearbeitet und gelagert, dass ihre biologische und chemische Information auch über lange Zeiträume konstant bleibt. Auf diese Weise machen es Umweltprobenbanken möglich, dass wir aktuelle Proben mit Archivmaterial vergleichen können, das vor Jahrzehnten gesammelt und eingelagert wurde.
Umweltverträgliche Nutzung des Untergrundes und Ressourcenschonung
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2014
Subjects: subject: Raumordnung
subject: Ressourcenschonung
subject: Unterirdische Raumplanung
subject: Grundsätze der Raumordnung
subject: Untertägige Raumplanung
subject: Abfall | Ressourcen
subject: Waste | Resources

description: Nutzungsansprüche an den Untergrund nehmen zu. Zugleich kann der Bergbau mit erheblichen Umweltbelastungen einhergehen. Das Positionspapier zeigt, wie eine untertägige ⁠Raumordnung⁠ konkret etabliert werden könnte und wie im Bergrecht insbesondere Umweltschutz, Öffentlichkeitsbeteiligung und Rechtsschutz gestärkt werden könnten. Zudem skizziert es, wie der Ressourcenschonung auch im Interesse künftiger Generationen besser Rechnung getragen werden könnte.
Entropy Ensemble Filter: A Modified Bootstrap Aggregating (Bagging) Procedure to Improve Efficiency in Ensemble Model Simulation
Creators: name: Foroozand, Hossein
name: Weijs, Steven
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Over the past two decades, the Bootstrap AGGregatING (bagging) method has been widely used for improving simulation. The computational cost of this method scales with the size of the ensemble, but excessively reducing the ensemble size comes at the cost of reduced predictive performance. The novel procedure proposed in this study is the Entropy Ensemble Filter (EEF), which uses the most informative training data sets in the ensemble rather than all ensemble members created by the bagging method. The results of this study indicate efficiency of the proposed method in application to synthetic data simulation on a sinusoidal signal, a sawtooth signal, and a composite signal. The EEF method can reduce the computational time of simulation by around 50% on average while maintaining predictive performance at the same level of the conventional method, where all of the ensemble models are used for simulation. The analysis of the error gradient (root mean square error of ensemble averages) shows that using the 40% most informative ensemble members of the set initially defined by the user appears to be most effective.
3289509.pdf
Creators: name: Zhao, Xiaoguang
name: Schalch, Jacob
name: Zhang, Jingdi
name: Seren, Huseyin
name: Duan, Guangwu
name: Averitt, Richard
name: Zhang, Xin
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: The document provides supplemental information to “Electromechanically Tunable Metasurface Transmission Waveplate at Terahertz Frequencies”.
Das Konzept der Nachhaltigkeit in der Sortimentspolitik des Handels - Ein Erfolgs- und Profilierungsfaktor
Creators: name: Ergenzinger, Rudolf
name: Krulis-Randa, Jan S.
Publisher: name: Deutscher Fachverlag
Year: 2008
Subjects: subject: 330 - Wirtschaft
subject: 650 - Management

description: Die Wünsche der Verbraucher wandeln sich schnell und die Lebensdauer von Produkten und Dienstleistungen wird immer kürzer. Welche Angebote sprechen den Kunden an? Welche Sortimente sichern die Wettbewerbsfähigkeit? Das Handbuch "Sortimentsstrategien in Industrie und Handel" beantwortet diese Fragen aus verschiedenen Perspektiven. Zum einen sind es branchenübergreifende Aspekte, wie z.B. Produktkrisen, Nachhaltigkeit, Verbundeffekte, Online-Ver-marktung und standortbezogene Faktoren, die für die Sortimentsplanung relevant sind. Zum anderen fließen die Besonderheiten der Lebensmittelbranche, der Baumärkte und der Automobilwirtschaft, in die Sortimentsstrategien ein. Themen wie situative Sortimentsgestaltung, Bio-Lebensmittel, Premiummarken, Brand Lands und Differenzierungsmöglichkeiten bei Baumärkten sind hier von hoher Wichtigkeit.
"The Country Wife" by William Wycherley: A TEI Edition of Gamini Salgado's 1968 Text
Creators: name: Pérez, Jesús Tronch
Publisher: name: Zenodo
Year: 2019
Subjects: early modern European theatre
The Country Wife
William Wycherley
TEI edition
English Theatre 1500-1700

description: An electronic edition, encoded by Jesús Tronch in XML language following the Guidelines of the Text Encoding Initiative, of Gamini Salgado's edition of William Wycherley's play The Country Wife published in Three Restoration Comedies (Harmondsworth: Penguin Books, 1968). This TEI edition is the basis of the HTML-PHP text published in the EMOTHE Digital Library
description: Funded by Ministerio de Ciencia, Innovación y Universidades, Agencia Estatal de Investigación (Spain) and FEDER/ERDF through project FFI2016-80314-P. Salgado's text is reproduced with kind permission by Fenella Copplestone.
Injective sheaves with values in a category.
Creators: name: Wu, Yel-Chiang.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1964
Subjects: subject: Mathematics.

description: In this thesis, we prove the following result: the category of sheaves with values in a Grothendieck category with a small generator and arbitrary products has enough injectives. The result remains valid if we replace the value-category by a Grothendieck category with a noetherian projective generator. The proofs are based on a theorem on transported structures which is due to J.M. Maranda.
title: Occupational Injuries in Germany
title: Population-Wide National Survey Data Emphasize the Importance of Work-Related Factors
titleType: Subtitle
Creators: name: Rommel, Alexander
name: Varnaccia, Gianni
name: Lahmann, Nils
name: Kottner, Jan
name: Kroll, Lars Eric
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Unintentional injuries cause much of the global mortality burden, with the workplace being a common accident setting. Even in high-income economies, occupational injury figures remain remarkably high. Because risk factors for occupational injuries are prone to confounding, the present research takes a comprehensive approach. To better understand the occurrence of occupational injuries, sociodemographic factors and work- and health-related factors are tested simultaneously. Thus, the present analysis aims to develop a comprehensive epidemiological model that facilitates the explanation of varying injury rates in the workplace. The representative phone survey German Health Update 2010 provides information on medically treated occupational injuries sustained in the year prior to the interview. Data were collected on sociodemographics, occupation, working conditions, health-related behaviors, and chronic diseases. For the economically active population (18–70 years, n = 14,041), the 12-month prevalence of occupational injuries was calculated with a 95% confidence interval (CI). Blockwise multiple logistic regression was applied to successively include different groups of variables. Overall, 2.8% (95% CI 2.4–3.2) of the gainfully employed population report at least one occupational injury (women: 0.9%; 95% CI 0.7–1.2; men: 4.3%; 95% CI 3.7–5.0). In the fully adjusted model, male gender (OR 3.16) and age 18–29 (OR 1.54), as well as agricultural (OR 5.40), technical (OR 3.41), skilled service (OR 4.24) or manual (OR 5.12), and unskilled service (OR 3.13) or manual (OR 4.97) occupations are associated with higher chances of occupational injuries. The same holds for frequent stressors such as heavy carrying (OR 1.78), working in awkward postures (OR 1.46), environmental stress (OR 1.48), and working under pressure (OR 1.41). Among health-related variables, physical inactivity (OR 1.47) and obesity (OR 1.73) present a significantly higher chance of occupational injuries. While the odds for most work-related factors were as expected, the associations for health-related factors such as smoking, drinking, and chronic diseases were rather weak. In part, this may be due to context-specific factors such as safety and workplace regulations in high- income countries like Germany. This assumption could guide further research, taking a multi-level approach to international comparisons.
20 Jahre Anlaufstelle Basler Übereinkommen
Creators: name: Wielenga, Kees
Publisher: name: My University
Year: 2016
Subjects: Abfallverbringungsgesetz

description: Der Bericht fasst die verschiedenen Beiträge der Teilnehmerinnen und Teilnehmer zusammen und hebt die aktuellen Herausforderungen sowie mögliche Verbesserungsmaßnahmen hervor. Er dient als Inspiration für alle Akteure, welche sich mit der internationalen Optimierung der Abfallwirtschaft auseinandersetzen.
This report gives a reflection of the different contributions of the speakers and the participants and highlights the new challenges and possible ways forward. This may serve as inspiration for those involved in the international development of instruments to improve the management of waste.Quelle: http://www.umweltbundesamt.de
The Jaguar and the Mayan Cultures
Creators: name: Croes, Dale R.
Publisher: name: Washington State University
Year: 1969
Subjects: Cultural Anthropology

description: The jaguar is the largest cat found on the .American continent, where it ranges from Texas through Central and South America to Patagonia. The jaguar easily adapted to the area known as the Mayan region. Before man's arrival this giant cat had few enemies. After man appeared he and the jaguar subsisted side by side in natural fear of one another. The jaguar could not relate his association with humans, but man, being of a symbolic nature, had attempted to define his relationship with this spotted cat. This paper is an attempt to show how the Mayan felt towards the jaguar and used his symbol in their culture. As an animal the jaguar was continually present to the peoples of Middle America. People in this area undoubtedly often came into contact with this mysterious cat of the forest. They saw the jaguar in their surrounding territory and could hear the cry of this great cat at night. This cry is deep and hoarse in tone, and consists of the sound pu pu, often repeated. The jaguar is basically yellow-gold with rosette-like spots. It is powerfully built, with a large head. A big male has a mouth wide enough to encase a humans' head. The jaguar some­times attains a length of nine feet, of which the tail comprises some two and a half feet and a large male can weigh up to 400 lbs. This cat usually avoids man and rarely purposely attacks him unless wounded, trapped, or pressed by hunger. It is a skillful climber and preys basically upon deer and small mammals and sometimes upon fish. It has has developed a fond love of water.
Internationale Marketing-Strategien und Marketing-Aktivitäten mit Fokus auf China
Creators: name: Ergenzinger, Rudolf
name: Krulis-Randa, Jan S.
Publisher: name: Springer
Year: 2007
Subjects: subject: 330 - Wirtschaft
subject: 650 - Management

description: Der rasante Aufstieg Chinas zur wirtschaftlichen Macht zwingt europäische Manager, sich mit den wirtschaftlich relevanten Bedingungen Chinas auseinanderzusetzen und geeignete Strategien zu finden. Dieser Sammelband führt in allgemeine Wettbewerbsstrategien ein und untersucht im besonderen geeignete Strategien für den Wettbewerb auf dem chinesischen Markt. Die Beiträge stammen von Management-Spezialisten der GSBA Zürich aus Europa, Asien und den USA.
The engineering of biomolecular systems for chemoselective surface grafting and innovative aptamer biosensing
Creators: name: Hast, Kern Robert Charles
Publisher: name: No Publisher Supplied
Year: 2024

description: This dissertation addresses challenges across biomolecular engineering, encompassing materials science, surface chemistry, biosensing, enzyme inhibition, and DNA nanotechnology. The core aim is to advance medical applications through innovative biomolecular engineering. First is an exploration of chemoselective methods for molecule grafting with DOPA-derived species. It begins with a novel surface functionalization method, merging catechol polymerization and copper-catalyzed alkyne−azide cycloaddition. This technique offers exceptional speed, chemoselectivity, and microvolume coating capability, applicable from preventing bacterial adhesion to tissue engineering. The subsequent chapter expands on this work to describe a bioorthogonal surface functionalization method using tyrosinase-catalyzed catecholamine polymerization and tetrazine ligation, eliminating the need for transition metals. Successful surface grafting of diverse molecules demonstrates its potential for biomedical applications, and demonstrates the value of the method for chemoselective biomolecule grafting.The dissertation then advances further into molecular diagnostics with a systematic methodology for split aptamer biosensors designed for chemical modification-free miRNA detection. This modular split aptamer platform exhibits single-nucleotide specificity and sensitivity in complex biological environments.Finally, the dissertation describes preliminary work in two fields. First is the exploration of synthetic polymers as potential enzyme inhibitors, investigated through the inhibition of RNase A. Significant progress is made in assay development, automated synthesis, and data analysis, contributing to the broader goal of developing these inhibitors. Finally, work is done to expand the scope of DNA nanotechnology through nucleic acid sensors that can be generally integrated into existing DNA nanotechnology, proposing novel mechanisms for dynamic DNA nanotechnologies to interface with diverse biological systems. The study begins to elucidate essential design principles and describes an efficient testing method, offering valuable insights for future work toward achieving this goal.
3289509.pdf
Creators: name: Zhao, Xiaoguang
name: Schalch, Jacob
name: Zhang, Jingdi
name: Seren, Huseyin
name: Duan, Guangwu
name: Averitt, Richard
name: Zhang, Xin
Publisher: name: Optica Publishing Group
Year: 2018
Subjects: Uncategorized

description: The document provides supplemental information to “Electromechanically Tunable Metasurface Transmission Waveplate at Terahertz Frequencies”.