cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: A critical legal analysis of prosecutorial discretion at the International Criminal Court: towards more transparency, accountability, and legitimacy
Creators: name: Pues, Anni Henriette
Publisher: name: University of Glasgow
Year: 2017
Subjects: subject: International Criminal Court, prosecutorial discretion, Llegitimacy, accountability, transparency.

description: The Prosecutor is the gatekeeper at the ICC. Her discretionary decisions determine in which situations the Court will commence an investigation and who will be brought before the Court. The Prosecutor’s focus on Africa has led to severe criticism of alleged anti-African bias and an erosion of the Court's legitimacy. Against this background, this thesis examines the exercise of prosecutorial discretion at the ICC. It identifies the scope for procedural discretionary decisions at the key junctures of the proceedings, covering areas such as how to conduct a preliminary examination, when to commence an investigation, who to prosecute and which charges to bring. The analysis is based on the theoretical understanding that the legality of decisions is crucial, which is why the thesis analyses the legal limitations of the exercise of discretion to clearly determine its boundaries. However, legality alone is not sufficient to serve the aim of safeguarding and enhancing the legitimacy of the Court. It is argued that the Prosecutor is not entirely free, but bound by the main principles and aims represented in the Rome Statute. She must ensure that her decisions demonstrate impartiality, maximize the deterrence effect of the ICC, and respond to victims' interests. To achieve a positive effect on the legitimacy of the Court, it is also required that the Prosecutor deliberates on individual decisions and makes these decisions more transparent. This will provide routes to pragmatic mechanisms of accountability, beyond the limited possibilities in the Rome Statute to hold the Prosecutor formally to account. In this regard, the thesis also analyses the role of the gravity notion, a concept that gained increased prominence in the evolving practice of the Prosecutor, and of the interests of justice, a notion that has not once been used yet. Both are indeterminate concepts that equip the Prosecutor with the necessary flexibility to respond to a variety of very different scenarios that might occur within the jurisdiction of the Court. The thesis demonstrates that the acts of applying these concepts contain a type of interpretative discretion. For the gravity notion, however, the scope is very limited, does not allow any managerial considerations, and must strictly be geared towards consistency. While the interests of justice currently appear redundant, this thesis demonstrates how this concept can gain new importance for the completion of situations, one of the challenges ahead for the Court. Overall, this thesis aims to identify avenues by which the Prosecutor can contribute to turning the Court into a more responsive institution, striking a balance between the preservation of its independence and open interaction with its stakeholders.
Les Sept Contrastes De Couleurs, D'Après Johannes Itten.
Creators: name: MASRI Dorra
Publisher: name: Zenodo
Year: 2018
Subjects: Art
Design
Couleur
Johannes Itten
Sept contraste

description: Cette ressource a pour objectif de présenter et de définir les sept contrastes de couleur d'après le théoricien de la couleur et de la forme Johannes Itten.
Literature review and methodological considerations for understanding circulating risk biomarkers following trauma exposure
Creators: name: Zannas, Anthony S.
name: McLean, Samuel A.
name: Koenen, Karestan C.
name: Linnstaedt, Sarah D.
name: Ressler, Kerry J.
Publisher: name: Springer Nature
Year: 2019

description: Exposure to traumatic events is common. While many individuals recover following trauma exposure, a substantial subset develop adverse posttraumatic neuropsychiatric sequelae (APNS) such as posttraumatic stress, major depression, and regional or widespread chronic musculoskeletal pain. APNS cause substantial burden to the individual and to society, causing functional impairment and physical disability, risk for suicide, lost workdays, and increased health care costs. Contemporary treatment is limited by an inability to identify individuals at high risk of APNS in the immediate aftermath of trauma, and an inability to identify optimal treatments for individual patients. Our purpose is to provide a comprehensive review describing candidate blood-based biomarkers that may help to identify those at high risk of APNS and/or guide individual intervention decision-making. Such blood-based biomarkers include circulating biological factors such as hormones, proteins, immune molecules, neuropeptides, neurotransmitters, mRNA, and noncoding RNA expression signatures, while we do not review genetic and epigenetic biomarkers due to other recent reviews of this topic. The current state of the literature on circulating risk biomarkers of APNS is summarized, and key considerations and challenges for their discovery and translation are discussed. We also describe the AURORA study, a specific example of current scientific efforts to identify such circulating risk biomarkers and the largest study to date focused on identifying risk and prognostic factors in the aftermath of trauma exposure.
title: Small Modular Reactors: A Strategic Investment for Energy and Economic Security
Creators: name: Lenski, Shoshannah
name: Russell, Molly
name: Sit, Christine
Publisher: name: University of Michigan
Year: 2024
Subjects: subject: Policy Brief
subject: Small Modular Reactors
subject: SMRs
subject: Nuclear
subject: Nuclear Energy

description: In a new study published in Nature Energy, University of Michigan researchers Max Vanatta and Michael T. Craig, along with William R. Stewart, identify the conditions for SMR success by modeling the potential learning cost curve under different scenarios of investment, policies, and external environmental factors. They find that SMRs offer a viable, cost-effective clean energy solution for industrial heat with the support of well-designed tax policy and under realistic potential natural gas prices.
Understanding positive child health
Creators: name: Psioda, Matt
name: Fry, Rebecca C.
name: Bangma, Jacqueline T.
name: Hooper, Stephen R.
name: Kuban, Karl C. K.
name: Frazier, Jean A.
name: Douglass, Laurie
name: Kwiatkowski, Evan
name: Santos, Hudson P.
name: Joseph, Robert M.
name: O'Shea, Thomas M.
Publisher: name: Springer Nature
Year: 2019

description: In response to the commentary, we would like to thank the authors for their interest and thoughtful comments.
Calamodontophis ronaldoi Franco 2006
Creators: name: Nogueira, Cristiano C.
name: Argôlo, Antonio J. S.
name: Arzamendia, Vanesa
name: Azevedo, Josué A.
name: Barbo, Fausto E.
name: Bérnils, Renato S.
name: Bolochio, Bruna E.
name: Borges-Martins, Marcio
name: Brasil-Godinho, Marcela
name: Braz, Henrique
name: Buononato, Marcus A.
name: Cisneros-Heredia, Diego F.
name: Colli, Guarino R.
name: Costa, Henrique C.
name: Franco, Francisco L.
name: Giraudo, Alejandro
name: Gonzalez, Rodrigo C.
name: Guedes, Thaís
name: Hoogmoed, Marinus S.
name: Marques, Otavio A. V.
name: Montingelli, Giovanna G.
name: Passos, Paulo
name: Prudente, Ana L. C.
name: Rivas, Gilson A.
name: Sanchez, Paola M.
name: Serrano, Filipe C.
name: Silva Jr., Nelson J.
name: Strüssmann, Christine
name: Vieira-Alencar, João Paulo S.
name: Zaher, Hussam
name: Sawaya, Ricardo J.
name: Martins, Marcio
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Colubridae
Calamodontophis
Calamodontophis ronaldoi

description: Calamodontophis ronaldoi Franco et al., 2006
Type locality. General Carneiro, state of Paraná, Brazil.
Distribution. Endemic to Brazil (Plt. 348A). Recorded in Atlantic Forest (Plt. 348A) at intermediate to high elevations (Plt. 348B). Observed in the field in mosaics of grassland and forest (Franco et al., 2006).
description: Published as part of Nogueira, Cristiano C., Argôlo, Antonio J. S., Arzamendia, Vanesa, Azevedo, Josué A., Barbo, Fausto E., Bérnils, Renato S., Bolochio, Bruna E., Borges-Martins, Marcio, Brasil-Godinho, Marcela, Braz, Henrique, Buononato, Marcus A., Cisneros-Heredia, Diego F., Colli, Guarino R., Costa, Henrique C., Franco, Francisco L., Giraudo, Alejandro, Gonzalez, Rodrigo C., Guedes, Thaís, Hoogmoed, Marinus S., Marques, Otavio A. V., Montingelli, Giovanna G., Passos, Paulo, Prudente, Ana L. C., Rivas, Gilson A., Sanchez, Paola M., Serrano, Filipe C., Silva Jr., Nelson J., Strüssmann, Christine, Vieira-Alencar, João Paulo S., Zaher, Hussam, Sawaya, Ricardo J. & Martins, Marcio, 2019, Atlas of Brazilian Snakes: Verified Point-Locality Maps to Mitigate the Wallacean Shortfall in a Megadiverse Snake Fauna, pp. 1-274 in South American Journal of Herpetology 14 (s 1) on page 41, DOI: 10.2994/SAJH-D-19-00120.1, http://zenodo.org/record/10061686
Gomesophis brasiliensis
Creators: name: Nogueira, Cristiano C.
name: Argôlo, Antonio J. S.
name: Arzamendia, Vanesa
name: Azevedo, Josué A.
name: Barbo, Fausto E.
name: Bérnils, Renato S.
name: Bolochio, Bruna E.
name: Borges-Martins, Marcio
name: Brasil-Godinho, Marcela
name: Braz, Henrique
name: Buononato, Marcus A.
name: Cisneros-Heredia, Diego F.
name: Colli, Guarino R.
name: Costa, Henrique C.
name: Franco, Francisco L.
name: Giraudo, Alejandro
name: Gonzalez, Rodrigo C.
name: Guedes, Thaís
name: Hoogmoed, Marinus S.
name: Marques, Otavio A. V.
name: Montingelli, Giovanna G.
name: Passos, Paulo
name: Prudente, Ana L. C.
name: Rivas, Gilson A.
name: Sanchez, Paola M.
name: Serrano, Filipe C.
name: Silva Jr., Nelson J.
name: Strüssmann, Christine
name: Vieira-Alencar, João Paulo S.
name: Zaher, Hussam
name: Sawaya, Ricardo J.
name: Martins, Marcio
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Colubridae
Gomesophis
Gomesophis brasiliensis

description: Gomesophis brasiliensis (Gomes, 1918)
Type locality. Pindamonhangaba, state of São Paulo, Brazil.
Distribution. Endemic to Brazil (Plt. 349A). Recorded in Araucaria Forest, Atlantic Forest, and adjacent Pampas Grasslands, with isolated records in Cerrado (Plt. 349A), often at high elevations (Plt. 349B). Found in grasslands and wetlands (Lema, 2002; FranÇa and Araújo, 2006).
description: Published as part of Nogueira, Cristiano C., Argôlo, Antonio J. S., Arzamendia, Vanesa, Azevedo, Josué A., Barbo, Fausto E., Bérnils, Renato S., Bolochio, Bruna E., Borges-Martins, Marcio, Brasil-Godinho, Marcela, Braz, Henrique, Buononato, Marcus A., Cisneros-Heredia, Diego F., Colli, Guarino R., Costa, Henrique C., Franco, Francisco L., Giraudo, Alejandro, Gonzalez, Rodrigo C., Guedes, Thaís, Hoogmoed, Marinus S., Marques, Otavio A. V., Montingelli, Giovanna G., Passos, Paulo, Prudente, Ana L. C., Rivas, Gilson A., Sanchez, Paola M., Serrano, Filipe C., Silva Jr., Nelson J., Strüssmann, Christine, Vieira-Alencar, João Paulo S., Zaher, Hussam, Sawaya, Ricardo J. & Martins, Marcio, 2019, Atlas of Brazilian Snakes: Verified Point-Locality Maps to Mitigate the Wallacean Shortfall in a Megadiverse Snake Fauna, pp. 1-274 in South American Journal of Herpetology 14 (s 1) on page 41, DOI: 10.2994/SAJH-D-19-00120.1, http://zenodo.org/record/10061686
Ptychophis flavovirgatus Gomes 1915
Creators: name: Nogueira, Cristiano C.
name: Argôlo, Antonio J. S.
name: Arzamendia, Vanesa
name: Azevedo, Josué A.
name: Barbo, Fausto E.
name: Bérnils, Renato S.
name: Bolochio, Bruna E.
name: Borges-Martins, Marcio
name: Brasil-Godinho, Marcela
name: Braz, Henrique
name: Buononato, Marcus A.
name: Cisneros-Heredia, Diego F.
name: Colli, Guarino R.
name: Costa, Henrique C.
name: Franco, Francisco L.
name: Giraudo, Alejandro
name: Gonzalez, Rodrigo C.
name: Guedes, Thaís
name: Hoogmoed, Marinus S.
name: Marques, Otavio A. V.
name: Montingelli, Giovanna G.
name: Passos, Paulo
name: Prudente, Ana L. C.
name: Rivas, Gilson A.
name: Sanchez, Paola M.
name: Serrano, Filipe C.
name: Silva Jr., Nelson J.
name: Strüssmann, Christine
name: Vieira-Alencar, João Paulo S.
name: Zaher, Hussam
name: Sawaya, Ricardo J.
name: Martins, Marcio
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Colubridae
Ptychophis
Ptychophis flavovirgatus

description: Ptychophis flavovirgatus Gomes, 1915
Type locality. São Bento do Sul, state of Santa Catarina, Brazil.
Distribution. Endemic to Brazil (Plt. 350A). Widespread in Araucaria Forest, with marginal records in the Atlantic Forest and Pampas Grasslands (Plt. 350A), mostly at high elevations (Plt. 350B). Observed in the field in aquatic habitats in open areas (Scartozzoni and Marques, 2004).
description: Published as part of Nogueira, Cristiano C., Argôlo, Antonio J. S., Arzamendia, Vanesa, Azevedo, Josué A., Barbo, Fausto E., Bérnils, Renato S., Bolochio, Bruna E., Borges-Martins, Marcio, Brasil-Godinho, Marcela, Braz, Henrique, Buononato, Marcus A., Cisneros-Heredia, Diego F., Colli, Guarino R., Costa, Henrique C., Franco, Francisco L., Giraudo, Alejandro, Gonzalez, Rodrigo C., Guedes, Thaís, Hoogmoed, Marinus S., Marques, Otavio A. V., Montingelli, Giovanna G., Passos, Paulo, Prudente, Ana L. C., Rivas, Gilson A., Sanchez, Paola M., Serrano, Filipe C., Silva Jr., Nelson J., Strüssmann, Christine, Vieira-Alencar, João Paulo S., Zaher, Hussam, Sawaya, Ricardo J. & Martins, Marcio, 2019, Atlas of Brazilian Snakes: Verified Point-Locality Maps to Mitigate the Wallacean Shortfall in a Megadiverse Snake Fauna, pp. 1-274 in South American Journal of Herpetology 14 (s 1) on page 41, DOI: 10.2994/SAJH-D-19-00120.1, http://zenodo.org/record/10061686
MPEC 2024-J08 : DAILY ORBIT UPDATE (2024 May 1)
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Association of Circulating Proinflammatory and Anti-inflammatory Protein Biomarkers in Extremely Preterm Born Children with Subsequent Brain Magnetic Resonance Imaging Volumes and Cognitive Function at Age 10 Years
Creators: name: Jara, Hernan
name: Paneth, Nigel
name: Rollins, Julie Vanier
name: Aakil, Adam
name: Horn, Mitchell
name: Beaulieu, Forrest
name: O'Shea, T. Michael
name: Cochran, David
name: Heeren, Timothy
name: Alshamrani, Khalid
name: Kuban, Karl C.K.
name: Hirtz, Deborah
name: ELGAN Study Investigators
name: Joseph, Robert M.
name: Douglass, Laurie M.
name: Frazier, Jean A.
name: Fichorova, Raina N.
Publisher: name: Elsevier
Year: 2019

description: 
Objectives
To examine elevated neonatal inflammatory and neurotrophic proteins from children born extremely preterm in relation to later childhood brain Magnetic Resonance Imaging volumes and cognition.
Study design
We measured circulating inflammation-related proteins and neurotrophic proteins on postnatal days 1, 7, and 14 in 166 children at 10 years of age (73 males; 93 females). Top quartile levels on ≥2 days for ≥3 inflammation-related proteins and for ≥4 neurotrophic proteins defined exposure. We examined associations among protein levels, brain Magnetic Resonance Imaging volumes, and cognition with multiple linear and logistic regressions.
Results
Analyses were adjusted for gestational age at birth and sex. Children with ≥3 elevated inflammation-related proteins had smaller grey matter, brain stem/cerebellar, and total brain volumes than those without elevated inflammation-related proteins, adjusted for neurotrophic proteins. When adjusted for inflammation-related proteins, children with ≥4 neurotrophic proteins, compared with children with no neurotrophic proteins, had larger grey matter and total brain volumes. Higher grey matter, white matter, and cerebellum and brainstem volumes were significantly correlated with higher IQ. Grey and white matter volumes were correlated with each other (r = −0.18; P = .021), and cerebellum and brainstem was highly correlated with grey matter (r = 0.55; P < .001) and white matter (r = 0.29; P < .001). Adjusting for other brain compartments, cerebellum and brainstem was associated with IQ (P = .016), but the association with white matter was marginally significant (P = .051). Grey matter was not associated with IQ. After adjusting for brain volumes, elevated inflammation-related proteins remained significantly associated with a lower IQ, and elevated neurotrophic proteins remained associated with a higher IQ.
Conclusions
Newborn inflammatory and neurotrophin protein levels are associated with later brain volumes and cognition, but their effects on cognition are not entirely explained by altered brain volumes.
Neuromodulation of sleep rhythms in schizophrenia: Towards the rational design of non-invasive brain stimulation
Creators: name: Lustenberger, Caroline
name: Fröhlich, Flavio
Publisher: name: Elsevier
Year: 2020

description: Brain function critically depends on oscillatory synchronization of neuronal populations both during wake and sleep. Originally, neural oscillations have been discounted as an epiphenomenon. More recently, specific deficits in the structure of brain oscillations have been linked to psychiatric diseases. For example, schizophrenia is hallmarked by abnormalities in different brain oscillations. Key sleep rhythms during NEM sleep such as sleep spindles, which are implicated in memory consolidation and are related to cognitive functions, are strongly diminished in these patients compared to healthy controls. To date, it remains unclear whether these reductions in sleep oscillations are causal for the functional impairments observed in schizophrenia. The application of non-invasive brain stimulation permits the causal examination of brain network dynamics and will help to establish the causal association of sleep oscillations and symptoms of schizophrenia. To accomplish this, stimulation paradigms that selectively engage specific network targets such as sleep spindles or slow waves are needed. We propose that the successful development and application of these non-invasive brain stimulation approaches will require rational design that takes network dynamics and neuroanatomical information into account. The purpose of this article is to prepare the grounds for the next steps towards such rational design of non-invasive stimulation, with a special focus on electrical and auditory stimulation. First, we briefly summarize the deficits in network dynamics during sleep in schizophrenia. Then, we discuss today's and tomorrow's non-invasive brain stimulation modalities to engage these network targets.
Thamnodynastes almae Franco and Ferreira 2002
Creators: name: Nogueira, Cristiano C.
name: Argôlo, Antonio J. S.
name: Arzamendia, Vanesa
name: Azevedo, Josué A.
name: Barbo, Fausto E.
name: Bérnils, Renato S.
name: Bolochio, Bruna E.
name: Borges-Martins, Marcio
name: Brasil-Godinho, Marcela
name: Braz, Henrique
name: Buononato, Marcus A.
name: Cisneros-Heredia, Diego F.
name: Colli, Guarino R.
name: Costa, Henrique C.
name: Franco, Francisco L.
name: Giraudo, Alejandro
name: Gonzalez, Rodrigo C.
name: Guedes, Thaís
name: Hoogmoed, Marinus S.
name: Marques, Otavio A. V.
name: Montingelli, Giovanna G.
name: Passos, Paulo
name: Prudente, Ana L. C.
name: Rivas, Gilson A.
name: Sanchez, Paola M.
name: Serrano, Filipe C.
name: Silva Jr., Nelson J.
name: Strüssmann, Christine
name: Vieira-Alencar, João Paulo S.
name: Zaher, Hussam
name: Sawaya, Ricardo J.
name: Martins, Marcio
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Colubridae
Thamnodynastes
Thamnodynastes almae

description: Thamnodynastes almae Franco and Ferreira, 2002
Type locality. Luiz Gonzaga hydroelectric Power Plant, rio São Francisco, Rodelas, state of Bahia, Brazil.
Distribution. Endemic to Brazil, recorded in Caatinga (Plt. 351A), at low elevations (Plt. 351B). Observed in the field in open areas (Hamdan and Lira-da-Silva, 2012; Guedes et al., 2014).
description: Published as part of Nogueira, Cristiano C., Argôlo, Antonio J. S., Arzamendia, Vanesa, Azevedo, Josué A., Barbo, Fausto E., Bérnils, Renato S., Bolochio, Bruna E., Borges-Martins, Marcio, Brasil-Godinho, Marcela, Braz, Henrique, Buononato, Marcus A., Cisneros-Heredia, Diego F., Colli, Guarino R., Costa, Henrique C., Franco, Francisco L., Giraudo, Alejandro, Gonzalez, Rodrigo C., Guedes, Thaís, Hoogmoed, Marinus S., Marques, Otavio A. V., Montingelli, Giovanna G., Passos, Paulo, Prudente, Ana L. C., Rivas, Gilson A., Sanchez, Paola M., Serrano, Filipe C., Silva Jr., Nelson J., Strüssmann, Christine, Vieira-Alencar, João Paulo S., Zaher, Hussam, Sawaya, Ricardo J. & Martins, Marcio, 2019, Atlas of Brazilian Snakes: Verified Point-Locality Maps to Mitigate the Wallacean Shortfall in a Megadiverse Snake Fauna, pp. 1-274 in South American Journal of Herpetology 14 (s 1) on page 41, DOI: 10.2994/SAJH-D-19-00120.1, http://zenodo.org/record/10061686
Preparation and enzyme-like catalytic mechanism of iron-based nanozymes
Creators: name: Dong, Haijiao
Publisher: name: Monash University
Year: 2025
Subjects: classificationCode: 340301
subject: Inorganic materials (incl. nanomaterials)
classificationCode: 401807
subject: Nanomaterials
classificationCode: 310607
subject: Nanobiotechnology

description: In this thesis, a variety of iron-based nanozymes, namely iron oxide, lithium iron phosphate, and Prussian blue. were first prepared using chemical synthesis methods. Then, the depletable nature of iron oxide peroxides nanozymes accompanied by the separate migration of electrons and iron ions was revealed. Finally, the first Prussian blue peroxidase nanozyme reference material was developed.
Neuropeptides Modulate Local Astrocytes to Regulate Adult Hippocampal Neural Stem Cells
Creators: name: Jin, Peng
name: Olsen, Reid
name: Asrican, Brent
name: Lim, Szu-Aun
name: Bao, Hechen
name: Hu, Jessica
name: Wooten, Josh
name: Zhang, Feiran
name: Song, Juan
name: Wander, Connor
name: Quintanilla, Luis
name: Li, Ya-Dong
name: Luo, Yan-Jia
name: Yeh, Chia-Yu
Publisher: name: Elsevier
Year: 2020

description: Neural stem cells (NSCs) in the dentate gyrus (DG) reside in a specialized local niche that supports their neurogenic proliferation to produce adult-born neurons throughout life. How local niche cells interact at the circuit level to ensure continuous neurogenesis from NSCs remains unknown. Here we report the role of endogenous neuropeptide cholecystokinin (CCK), released from dentate CCK interneurons, in regulating neurogenic niche cells and NSCs. Specifically, stimulating CCK release supports neurogenic proliferation of NSCs through a dominant astrocyte-mediated glutamatergic signaling cascade. In contrast, reducing dentate CCK induces reactive astrocytes, which correlates with decreased neurogenic proliferation of NSCs and upregulation of genes involved in immune processes. Our findings provide novel circuit-based information on how CCK acts on local astrocytes to regulate the key behavior of adult NSCs.
Thamnodynastes nattereri
Creators: name: Nogueira, Cristiano C.
name: Argôlo, Antonio J. S.
name: Arzamendia, Vanesa
name: Azevedo, Josué A.
name: Barbo, Fausto E.
name: Bérnils, Renato S.
name: Bolochio, Bruna E.
name: Borges-Martins, Marcio
name: Brasil-Godinho, Marcela
name: Braz, Henrique
name: Buononato, Marcus A.
name: Cisneros-Heredia, Diego F.
name: Colli, Guarino R.
name: Costa, Henrique C.
name: Franco, Francisco L.
name: Giraudo, Alejandro
name: Gonzalez, Rodrigo C.
name: Guedes, Thaís
name: Hoogmoed, Marinus S.
name: Marques, Otavio A. V.
name: Montingelli, Giovanna G.
name: Passos, Paulo
name: Prudente, Ana L. C.
name: Rivas, Gilson A.
name: Sanchez, Paola M.
name: Serrano, Filipe C.
name: Silva Jr., Nelson J.
name: Strüssmann, Christine
name: Vieira-Alencar, João Paulo S.
name: Zaher, Hussam
name: Sawaya, Ricardo J.
name: Martins, Marcio
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Colubridae
Thamnodynastes
Thamnodynastes nattereri

description: Thamnodynastes cf. nattereri (Mikan, 1820)
Type locality. “Sebastianópolis,” currently Rio de Janeiro, state of Rio de Janeiro, Brazil, (U. Caramaschi, pers. comm. in Franco and Ferreira, 2002). Coluber nattereri was formerly in the synonymy of T. strigilis (Thunberg, 1787), a name adopted for many Thamnodynastes species with 19 keeled dorsal scale rows (Franco and Ferreira, 2002). The type specimen is lost, and ongoing taxonomic studies (V. Trevine, pers. comm.) will clarify the association of a name to this species, which is diagnosable from all known congeners with 19 dorsal scale rows by its weakly keeled dorsals and the immaculate ventral portion of head (Franco and Ferreira, 2002).
Distribution. Known from Brazil and Uruguay (Plt. 352A). In Brazil, widespread in the Atlantic Forest, with marginal records in Pampas Grasslands, Araucaria Forest, and Caatinga (Plt. 352A). Recorded from low to intermediate elevations (Plt. 352B). Observed in the field in forest (Marques and Sazima, 2004; Hartmann et al., 2009; Dorigo et al., 2014) and open areas (Guedes et al., 2014).
description: Published as part of Nogueira, Cristiano C., Argôlo, Antonio J. S., Arzamendia, Vanesa, Azevedo, Josué A., Barbo, Fausto E., Bérnils, Renato S., Bolochio, Bruna E., Borges-Martins, Marcio, Brasil-Godinho, Marcela, Braz, Henrique, Buononato, Marcus A., Cisneros-Heredia, Diego F., Colli, Guarino R., Costa, Henrique C., Franco, Francisco L., Giraudo, Alejandro, Gonzalez, Rodrigo C., Guedes, Thaís, Hoogmoed, Marinus S., Marques, Otavio A. V., Montingelli, Giovanna G., Passos, Paulo, Prudente, Ana L. C., Rivas, Gilson A., Sanchez, Paola M., Serrano, Filipe C., Silva Jr., Nelson J., Strüssmann, Christine, Vieira-Alencar, João Paulo S., Zaher, Hussam, Sawaya, Ricardo J. & Martins, Marcio, 2019, Atlas of Brazilian Snakes: Verified Point-Locality Maps to Mitigate the Wallacean Shortfall in a Megadiverse Snake Fauna, pp. 1-274 in South American Journal of Herpetology 14 (s 1) on page 41, DOI: 10.2994/SAJH-D-19-00120.1, http://zenodo.org/record/10061686
Progesterone modulates theta oscillations in the frontal-parietal network
Creators: name: Ahn, Sangtae
name: Girdler, Susan
name: Frohlich, Flavio
name: Riddle, Justin
name: McPherson, Trevor
Publisher: name: Wiley
Year: 2020

description: The neuroactive metabolites of the steroid hormones progesterone (P4) and testosterone (T) are GABAergic modulators that influence cognition, yet, the specific effect of P4 and T on brain network activity remains poorly understood. Here, we investigated if a fundamental oscillatory network activity pattern, often related to cognitive control, frontal midline theta (FMT) oscillations, are modulated by steroids hormones, P4 and T. We measured the concentration of P4 and T using salivary enzyme immunoassay and FMT oscillations using high-density electroencephalography (EEG) during eyes-open resting-state in 55 healthy women and men. Electrical brain activity was analyzed using Fourier analysis, aperiodic signal fitting, and beamformer source localization. Steroid hormone concentrations and biological sex were used as predictors for scalp and source-estimated amplitude of theta oscillations. Elevated concentrations of P4 predicted increased amplitude of FMT oscillations across both sexes, and no relationship was found with T. The positive correlation with P4 was specific to the frontal midline electrodes and survived correction for the background aperiodic signal of the brain. Using source localization, FMT oscillations were localized to the frontal-parietal network (FPN). Additionally, theta amplitude within the FPN, but not the default mode network, positively correlated with P4 concentration. Our results suggest that P4 concentration modulates brain activity via upregulation of theta oscillations in the FPN.
Thamnodynastes chaquensis Bergna and Alvarez 1993
Creators: name: Nogueira, Cristiano C.
name: Argôlo, Antonio J. S.
name: Arzamendia, Vanesa
name: Azevedo, Josué A.
name: Barbo, Fausto E.
name: Bérnils, Renato S.
name: Bolochio, Bruna E.
name: Borges-Martins, Marcio
name: Brasil-Godinho, Marcela
name: Braz, Henrique
name: Buononato, Marcus A.
name: Cisneros-Heredia, Diego F.
name: Colli, Guarino R.
name: Costa, Henrique C.
name: Franco, Francisco L.
name: Giraudo, Alejandro
name: Gonzalez, Rodrigo C.
name: Guedes, Thaís
name: Hoogmoed, Marinus S.
name: Marques, Otavio A. V.
name: Montingelli, Giovanna G.
name: Passos, Paulo
name: Prudente, Ana L. C.
name: Rivas, Gilson A.
name: Sanchez, Paola M.
name: Serrano, Filipe C.
name: Silva Jr., Nelson J.
name: Strüssmann, Christine
name: Vieira-Alencar, João Paulo S.
name: Zaher, Hussam
name: Sawaya, Ricardo J.
name: Martins, Marcio
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Colubridae
Thamnodynastes
Thamnodynastes chaquensis

description: Thamnodynastes chaquensis Bergna and Alvarez, 1993
Type locality. Colonia la Mercedes, San Fernando, province of Buenos Aires, Argentina.
Distribution. Known from Argentina, Bolivia, Brazil, and Paraguay (Plt. 353A). In Brazil, widespread in the Pantanal, with marginal records in the western portion of the Cerrado (Plt. 353A), mostly at low elevations (Plt. 353B). Observed in the field in dry forest, wetland, and wet savanna (Bellini et al., 2014).
description: Published as part of Nogueira, Cristiano C., Argôlo, Antonio J. S., Arzamendia, Vanesa, Azevedo, Josué A., Barbo, Fausto E., Bérnils, Renato S., Bolochio, Bruna E., Borges-Martins, Marcio, Brasil-Godinho, Marcela, Braz, Henrique, Buononato, Marcus A., Cisneros-Heredia, Diego F., Colli, Guarino R., Costa, Henrique C., Franco, Francisco L., Giraudo, Alejandro, Gonzalez, Rodrigo C., Guedes, Thaís, Hoogmoed, Marinus S., Marques, Otavio A. V., Montingelli, Giovanna G., Passos, Paulo, Prudente, Ana L. C., Rivas, Gilson A., Sanchez, Paola M., Serrano, Filipe C., Silva Jr., Nelson J., Strüssmann, Christine, Vieira-Alencar, João Paulo S., Zaher, Hussam, Sawaya, Ricardo J. & Martins, Marcio, 2019, Atlas of Brazilian Snakes: Verified Point-Locality Maps to Mitigate the Wallacean Shortfall in a Megadiverse Snake Fauna, pp. 1-274 in South American Journal of Herpetology 14 (s 1) on page 41, DOI: 10.2994/SAJH-D-19-00120.1, http://zenodo.org/record/10061686
Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells.
Creators: name: Song, Juan
name: Yeh, Chia-Yu
name: Quintanilla, Luis J
name: Bao, Hechen
name: Catavero, Christina
Publisher: name: MyJove
Year: 2019

description: Adult neurogenesis is a dynamic process by which newly activated neural stem cells (NSCs) in the subgranular zone (SGZ) of the dentate gyrus (DG) generate new neurons, which integrate into an existing neural circuit and contribute to specific hippocampal functions. Importantly, adult neurogenesis is highly susceptible to environmental stimuli, which allows for activity-dependent regulation of various cognitive functions. A vast range of neural circuits from various brain regions orchestrates these complex cognitive functions. It is therefore important to understand how specific neural circuits regulate adult neurogenesis. Here, we describe a protocol to manipulate neural circuit activity using designer receptor exclusively activated by designer drugs (DREADDs) technology that regulates NSCs and newborn progeny in rodents. This comprehensive protocol includes stereotaxic injection of viral particles, chemogenetic stimulation of specific neural circuits, thymidine analog administration, tissue processing, immunofluorescence labeling, confocal imaging, and imaging analysis of various stages of neural precursor cells. This protocol provides detailed instructions on antigen retrieval techniques used to visualize NSCs and their progeny and describes a simple, yet effective way to modulate brain circuits using clozapine N-oxide (CNO) or CNO-containing drinking water and DREADDs-expressing viruses. The strength of this protocol lies in its adaptability to study a diverse range of neural circuits that influence adult neurogenesis derived from NSCs.
Thamnodynastes hypoconia
Creators: name: Nogueira, Cristiano C.
name: Argôlo, Antonio J. S.
name: Arzamendia, Vanesa
name: Azevedo, Josué A.
name: Barbo, Fausto E.
name: Bérnils, Renato S.
name: Bolochio, Bruna E.
name: Borges-Martins, Marcio
name: Brasil-Godinho, Marcela
name: Braz, Henrique
name: Buononato, Marcus A.
name: Cisneros-Heredia, Diego F.
name: Colli, Guarino R.
name: Costa, Henrique C.
name: Franco, Francisco L.
name: Giraudo, Alejandro
name: Gonzalez, Rodrigo C.
name: Guedes, Thaís
name: Hoogmoed, Marinus S.
name: Marques, Otavio A. V.
name: Montingelli, Giovanna G.
name: Passos, Paulo
name: Prudente, Ana L. C.
name: Rivas, Gilson A.
name: Sanchez, Paola M.
name: Serrano, Filipe C.
name: Silva Jr., Nelson J.
name: Strüssmann, Christine
name: Vieira-Alencar, João Paulo S.
name: Zaher, Hussam
name: Sawaya, Ricardo J.
name: Martins, Marcio
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Colubridae
Thamnodynastes
Thamnodynastes hypoconia

description: Thamnodynastes hypoconia (Cope, 1860)
Type locality. Buenos Aires, Argentina.
Distribution. Known from Argentina, Brazil, Paraguay, and Uruguay (Plt. 354A). In Brazil, widespread in the Cerrado, Pantanal, Atlantic Forest, and Pampas Grasslands, with marginal records in the Araucaria Forest and the Caatinga (Plt. 354A) from low to high elevations (Plt. 354B). Observed in the field in wet grasslands, palm marshes, and gallery forest (FranÇa and Araújo, 2006; Martins et al., 2008b; Hartmann et al., 2009; Guedes et al., 2014).
description: Published as part of Nogueira, Cristiano C., Argôlo, Antonio J. S., Arzamendia, Vanesa, Azevedo, Josué A., Barbo, Fausto E., Bérnils, Renato S., Bolochio, Bruna E., Borges-Martins, Marcio, Brasil-Godinho, Marcela, Braz, Henrique, Buononato, Marcus A., Cisneros-Heredia, Diego F., Colli, Guarino R., Costa, Henrique C., Franco, Francisco L., Giraudo, Alejandro, Gonzalez, Rodrigo C., Guedes, Thaís, Hoogmoed, Marinus S., Marques, Otavio A. V., Montingelli, Giovanna G., Passos, Paulo, Prudente, Ana L. C., Rivas, Gilson A., Sanchez, Paola M., Serrano, Filipe C., Silva Jr., Nelson J., Strüssmann, Christine, Vieira-Alencar, João Paulo S., Zaher, Hussam, Sawaya, Ricardo J. & Martins, Marcio, 2019, Atlas of Brazilian Snakes: Verified Point-Locality Maps to Mitigate the Wallacean Shortfall in a Megadiverse Snake Fauna, pp. 1-274 in South American Journal of Herpetology 14 (s 1) on page 42, DOI: 10.2994/SAJH-D-19-00120.1, http://zenodo.org/record/10061686
Genetic and epigenetic factors and early life inflammation as predictors of neurodevelopmental outcomes
Creators: name: O'Shea, T Michael
name: Fry, Rebecca C
name: Oldenburg, Kirsi S
Publisher: name: Elsevier
Year: 2020

description: Among individuals born very preterm, perinatal inflammation, particularly if sustained or recurring, is highly likely to contribute to adverse neurodevelopmental outcomes, including cerebral white matter damage, cerebral palsy, cognitive impairment, attention-deficit/hyperactivity disorder, and autism spectrum disorder. Antecedents and correlates of perinatal inflammation include socioeconomic disadvantage, maternal obesity, maternal infections, fetal growth restriction, neonatal sepsis, necrotizing enterocolitis, and prolonged mechanical ventilation. Genetic factors can modify susceptibility to perinatal inflammation and to neurodevelopmental disorders. Preliminary evidence supports a role of epigenetic markers as potential mediators of the presumed effects of preterm birth and/or its consequences on neurodevelopment later in life. Further study is needed of factors such as sex, psychosocial stressors, and environmental exposures that could modify the relationship of early life inflammation to later neurodevelopmental impairments. Also needed are pharmacological and non-pharmacological interventions to attenuate inflammation towards the goal of improving the neurodevelopment of individuals born very preterm.
Thamnodynastes lanei Bailey 2005
Creators: name: Nogueira, Cristiano C.
name: Argôlo, Antonio J. S.
name: Arzamendia, Vanesa
name: Azevedo, Josué A.
name: Barbo, Fausto E.
name: Bérnils, Renato S.
name: Bolochio, Bruna E.
name: Borges-Martins, Marcio
name: Brasil-Godinho, Marcela
name: Braz, Henrique
name: Buononato, Marcus A.
name: Cisneros-Heredia, Diego F.
name: Colli, Guarino R.
name: Costa, Henrique C.
name: Franco, Francisco L.
name: Giraudo, Alejandro
name: Gonzalez, Rodrigo C.
name: Guedes, Thaís
name: Hoogmoed, Marinus S.
name: Marques, Otavio A. V.
name: Montingelli, Giovanna G.
name: Passos, Paulo
name: Prudente, Ana L. C.
name: Rivas, Gilson A.
name: Sanchez, Paola M.
name: Serrano, Filipe C.
name: Silva Jr., Nelson J.
name: Strüssmann, Christine
name: Vieira-Alencar, João Paulo S.
name: Zaher, Hussam
name: Sawaya, Ricardo J.
name: Martins, Marcio
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Colubridae
Thamnodynastes
Thamnodynastes lanei

description: Thamnodynastes lanei Bailey et al., 2005
Type locality. Salobra, Miranda, state of Mato Grosso do Sul, Brazil.
Distribution. Known from Argentina, Bolivia, Brazil, and Paraguay (Plt. 355A). In Brazil, recorded in Amazonia, Pantanal, and the western portion of the Cerrado (Plt. 355A) at low elevations (Plt. 355B). Maps and taxonomy in Bailey et al. (2005). Observed in the field in seasonally flooded areas (Bailey et al., 2005).
description: Published as part of Nogueira, Cristiano C., Argôlo, Antonio J. S., Arzamendia, Vanesa, Azevedo, Josué A., Barbo, Fausto E., Bérnils, Renato S., Bolochio, Bruna E., Borges-Martins, Marcio, Brasil-Godinho, Marcela, Braz, Henrique, Buononato, Marcus A., Cisneros-Heredia, Diego F., Colli, Guarino R., Costa, Henrique C., Franco, Francisco L., Giraudo, Alejandro, Gonzalez, Rodrigo C., Guedes, Thaís, Hoogmoed, Marinus S., Marques, Otavio A. V., Montingelli, Giovanna G., Passos, Paulo, Prudente, Ana L. C., Rivas, Gilson A., Sanchez, Paola M., Serrano, Filipe C., Silva Jr., Nelson J., Strüssmann, Christine, Vieira-Alencar, João Paulo S., Zaher, Hussam, Sawaya, Ricardo J. & Martins, Marcio, 2019, Atlas of Brazilian Snakes: Verified Point-Locality Maps to Mitigate the Wallacean Shortfall in a Megadiverse Snake Fauna, pp. 1-274 in South American Journal of Herpetology 14 (s 1) on page 42, DOI: 10.2994/SAJH-D-19-00120.1, http://zenodo.org/record/10061686
Thamnodynastes longicaudus Franco 2003
Creators: name: Nogueira, Cristiano C.
name: Argôlo, Antonio J. S.
name: Arzamendia, Vanesa
name: Azevedo, Josué A.
name: Barbo, Fausto E.
name: Bérnils, Renato S.
name: Bolochio, Bruna E.
name: Borges-Martins, Marcio
name: Brasil-Godinho, Marcela
name: Braz, Henrique
name: Buononato, Marcus A.
name: Cisneros-Heredia, Diego F.
name: Colli, Guarino R.
name: Costa, Henrique C.
name: Franco, Francisco L.
name: Giraudo, Alejandro
name: Gonzalez, Rodrigo C.
name: Guedes, Thaís
name: Hoogmoed, Marinus S.
name: Marques, Otavio A. V.
name: Montingelli, Giovanna G.
name: Passos, Paulo
name: Prudente, Ana L. C.
name: Rivas, Gilson A.
name: Sanchez, Paola M.
name: Serrano, Filipe C.
name: Silva Jr., Nelson J.
name: Strüssmann, Christine
name: Vieira-Alencar, João Paulo S.
name: Zaher, Hussam
name: Sawaya, Ricardo J.
name: Martins, Marcio
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Colubridae
Thamnodynastes
Thamnodynastes longicaudus

description: Thamnodynastes longicaudus Franco et al., 2003
Type locality. São LourenÇo da Serra, state of São Paulo, Brazil.
Distribution. Endemic to Brazil, restricted to the southeastern portion of the Atlantic Forest (Plt. 356A), at intermediate to high elevations (Plt. 356B). No detailed field data on habitat use are available for this species.
description: Published as part of Nogueira, Cristiano C., Argôlo, Antonio J. S., Arzamendia, Vanesa, Azevedo, Josué A., Barbo, Fausto E., Bérnils, Renato S., Bolochio, Bruna E., Borges-Martins, Marcio, Brasil-Godinho, Marcela, Braz, Henrique, Buononato, Marcus A., Cisneros-Heredia, Diego F., Colli, Guarino R., Costa, Henrique C., Franco, Francisco L., Giraudo, Alejandro, Gonzalez, Rodrigo C., Guedes, Thaís, Hoogmoed, Marinus S., Marques, Otavio A. V., Montingelli, Giovanna G., Passos, Paulo, Prudente, Ana L. C., Rivas, Gilson A., Sanchez, Paola M., Serrano, Filipe C., Silva Jr., Nelson J., Strüssmann, Christine, Vieira-Alencar, João Paulo S., Zaher, Hussam, Sawaya, Ricardo J. & Martins, Marcio, 2019, Atlas of Brazilian Snakes: Verified Point-Locality Maps to Mitigate the Wallacean Shortfall in a Megadiverse Snake Fauna, pp. 1-274 in South American Journal of Herpetology 14 (s 1) on page 42, DOI: 10.2994/SAJH-D-19-00120.1, http://zenodo.org/record/10061686
Distributional Properties and Criterion Validity of a Shortened Version of the Social Responsiveness Scale: Results from the ECHO Program and Implications for Social Communication Research
Creators: name: Volk, Heather
name: Piven, Joseph
name: Pandey, Juhi
name: Ozonoff, Sally
name: Botteron, Kelly
name: Croen, Lisa A.
name: Schmidt, Rebecca
name: Catellier, Diane
name: Korrick, Susan
name: Karagas, Margaret R.
name: Kaat, Aaron J.
name: Constantino, John N.
name: Joseph, Robert M.
name: St. John, Tanya
name: Ning, Xuejuan
name: Hosseini, Mina
name: Newschaffer, Craig J.
name: Sathyanarayana, Sheela
name: Hertz-Picciotto, Irva
name: Bush, Nicole R.
name: Fallin, M. Daniele
name: Schultz, Robert T.
name: Dager, Stephen R.
name: Ladd-Acosta, Christine
name: Lyall, Kristen
name: Oken, Emily
name: Messinger, Daniel
name: Landa, Rebecca
name: Hazlett, Heather
name: Duarte, Cristiane S.
Publisher: name: Springer Nature
Year: 2020

description: Prior work proposed a shortened version of the Social Responsiveness Scale (SRS), a commonly used quantitative measure of social communication traits. We used data from 3031 participants (including 190 ASD cases) from the Environmental Influences on Child Health Outcomes (ECHO) Program to compare distributional properties and criterion validity of 16-item â€œshort" to 65-item â€œfull" SRS scores. Results demonstrated highly overlapping distributions of short and full scores. Both scores separated case from non-case individuals by approximately two standard deviations. ASD prediction was nearly identical for short and full scores (area under the curve values of 0.87, 0.86 respectively). Findings support comparability of shortened and full scores, suggesting opportunities to increase efficiency. Future work should confirm additional psychometric properties of short scores.
Thamnodynastes pallidus
Creators: name: Nogueira, Cristiano C.
name: Argôlo, Antonio J. S.
name: Arzamendia, Vanesa
name: Azevedo, Josué A.
name: Barbo, Fausto E.
name: Bérnils, Renato S.
name: Bolochio, Bruna E.
name: Borges-Martins, Marcio
name: Brasil-Godinho, Marcela
name: Braz, Henrique
name: Buononato, Marcus A.
name: Cisneros-Heredia, Diego F.
name: Colli, Guarino R.
name: Costa, Henrique C.
name: Franco, Francisco L.
name: Giraudo, Alejandro
name: Gonzalez, Rodrigo C.
name: Guedes, Thaís
name: Hoogmoed, Marinus S.
name: Marques, Otavio A. V.
name: Montingelli, Giovanna G.
name: Passos, Paulo
name: Prudente, Ana L. C.
name: Rivas, Gilson A.
name: Sanchez, Paola M.
name: Serrano, Filipe C.
name: Silva Jr., Nelson J.
name: Strüssmann, Christine
name: Vieira-Alencar, João Paulo S.
name: Zaher, Hussam
name: Sawaya, Ricardo J.
name: Martins, Marcio
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Colubridae
Thamnodynastes
Thamnodynastes pallidus

description: Thamnodynastes pallidus (Linnaeus, 1758)
Type locality. “Indiis” (in error).
Distribution. Known from Bolivia, Brazil, Colombia, Ecuador, French Guiana, Guyana, Peru, Suriname, and Venezuela (Plt. 357A). In Brazil, widespread in Amazonia and the northern part of the Atlantic Forest, with marginal records near its contact with the Caatinga, forming a disjunct distribution (Plt. 357A). Recorded mostly at low elevations (Plt. 357B). Maps and taxonomy in Bailey et al. (2005). Observed in the field in wet forest (Silveira et al., 2017), close to water (Cunha and Nascimento, 1993; McDiarmid and Donelly, 2005; Santana et al., 2008) and open areas (Guedes et al., 2014).
description: Published as part of Nogueira, Cristiano C., Argôlo, Antonio J. S., Arzamendia, Vanesa, Azevedo, Josué A., Barbo, Fausto E., Bérnils, Renato S., Bolochio, Bruna E., Borges-Martins, Marcio, Brasil-Godinho, Marcela, Braz, Henrique, Buononato, Marcus A., Cisneros-Heredia, Diego F., Colli, Guarino R., Costa, Henrique C., Franco, Francisco L., Giraudo, Alejandro, Gonzalez, Rodrigo C., Guedes, Thaís, Hoogmoed, Marinus S., Marques, Otavio A. V., Montingelli, Giovanna G., Passos, Paulo, Prudente, Ana L. C., Rivas, Gilson A., Sanchez, Paola M., Serrano, Filipe C., Silva Jr., Nelson J., Strüssmann, Christine, Vieira-Alencar, João Paulo S., Zaher, Hussam, Sawaya, Ricardo J. & Martins, Marcio, 2019, Atlas of Brazilian Snakes: Verified Point-Locality Maps to Mitigate the Wallacean Shortfall in a Megadiverse Snake Fauna, pp. 1-274 in South American Journal of Herpetology 14 (s 1) on page 42, DOI: 10.2994/SAJH-D-19-00120.1, http://zenodo.org/record/10061686
Recent progress on cheminformatics approaches to epigenetic drug discovery
Creators: name: Medina-Franco, Jose L
name: Sessions, Zoe
name: Alves, Vinicius M
name: Santos, Hudson P
name: Muratov, Eugene
name: Tropsha, Alexander
name: Prieto-Marti­nez, Fernando D
name: Sanchez-Cruz, Norberto
Publisher: name: Elsevier
Year: 2020

description: The ability of epigenetic markers to affect genome function has enabled transformative changes in drug discovery, especially in cancer and other emerging therapeutic areas. Concordant with the introduction of the term 'epi-informatics', the size of the epigenetically relevant chemical space has grown substantially and so did the number of applications of cheminformatic methods to epigenetics. Recent progress in epi-informatics has improved our understanding of the structure-epigenetic activity relationships and boosted the development of models predicting novel epigenetic agents. Herein, we review the advances in computational approaches to drug discovery of small molecules with epigenetic modulation profiles, summarize the current chemogenomics data available for epigenetic targets, and provide a perspective on the greater utility of biomedical knowledge mining as a means to advance the epigenetic drug discovery.