cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Epigenetic and Posttranscriptional Biomarkers of PTSD: A Scoping Review Protocol
Creators: name: Wellington, Nathan
name: Carter, Roger
name: Lagopoulos, Jim
name: Bouças, Ana
name: Kuballa, Anna
Publisher: name: University of the Sunshine Coast
Year: 2022
Subjects: post-traumatic stress disorder
epigenetics
biomarkers
microRNA

description: Objective: The objective of this scoping review is to explore current knowledge on the genetic regulation implicated with post-traumatic stress disorder (PTSD). Thereby identifying the dysregulated expression of epigenetic and post-transcriptional biomarkers that contribute to molecular perturbations see in PTSD and their diagnostic, prognostic and therapeutic values.
description: Introduction: PTSD sufferers continue to re-experience symptoms long after the trauma event. Whilst, research has identified neurotransmitter systems and neurobiological mechanisms that contribute to PTSD, there is little knowledge of the genetic alterations that underpin the pathophysiology of PTSD.
description: Inclusion criteria: This review examines all human, animal and cell culture studies identifying epigenetic changes in participants, as a consequence of PTSD. The studies will focus on biological markers through experimental design. It will include quantitative studies, meta-analyses, genome-wide and epigenome-wide association studies.
description: Methods: The databases to be searched will include Web of Science, Scopus, Global Health (CABI), PubMed. The search will be supplemented by scanning reference lists of relevant reviews, and hand-searching key journals specialising in PTSD. The search will focus on English publications after 1995. The titles and abstracts and full texts will be reviewed by two independent reviewers against the inclusion criteria. Any conflicting views will be resolved by discussion or a third reviewer. The resulting data will identify validated epigenetic and post-transcriptional changes (>1.5 fold or statistical significance) and their regional location. Consequently, they will be mapped to associated neurobiological signalling
Future research directions in acute lung injury: Summary of a National Heart, Lung, and Blood Institute Working Group
Creators: name: Gimbrone Jr., M.A.
name: Parsons, P.
name: Gail, D.B.
name: Coller, B.
name: Bhattacharya, J.
name: Tracey, K.J.
name: Munford, R.
name: Matalon, S.
name: Ward, P.
name: Floros, J.
name: Harabin, A.L.
name: Hoffman, E.
name: Slutsky, A.S.
name: Zimmerman, G.A.
name: Hubmayr, R.D.
name: Leppert, M.
name: Esmon, C.
name: Doerschuk, C.M.
name: Matthay, M.A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Acute lung injury (ALI) and its more severe form, the acute respiratory distress syndrome (ARDS), are syndromes of acute respiratory failure that result from acute pulmonary edema and inflammation. The development of ALI/ARDS is associated with several clinical disorders including direct pulmonary injury from pneumonia and aspiration as well as indirect pulmonary injury from trauma, sepsis, and other disorders such as acute pancreatitis and drug overdose. Although mortality from ALI/ARDS has decreased in the last decade, it remains high. Despite two major advances in treatment, low VT ventilation for ALI/ARDS and activated protein C for severe sepsis (the leading cause of ALI/ARDS), additional research is needed to develop specific treatments and improve understanding of the pathogenesis of these syndromes. The NHLBI convened a working group to develop specific recommendations for future ALI/ARDS research. Improved understanding of disease heterogeneity through use of evolving biologic, genomic, and genetic approaches should provide major new insights into pathogenesis of ALI. Cellular and molecular methods combined with animal and clinical studies should lead to further progress in the detection and treatment of this complex disease.
Supplementary document for Vortices-interaction-induced microstreaming for pump-free separation of particles - 5301720.pdf
Creators: name: Zhou, Ruixue
name: Yang, Jianxin
name: Zhang, Yanfeng
name: Luo, Fangjing
name: Chen, Yilin
name: Li, Yao
name: Luan, Tianyang
name: Shou, Qian
name: Jiang, Xiaofang
name: Hu, Xiaowen
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Separation Science
Flow Analysis

description: Supplement 1
Platelet endothelial cell adhesion molecule-1 in neutrophil emigration during acute bacterial pneumonia in mice and rats
Creators: name: Qin, L.
name: Albelda, S.M.
name: Tasaka, S.
name: Saijo, A.
name: Doerschuk, C.M.
name: DeLisser, H.M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Platelet endothelial cell adhesion molecule-1 (PECAM-1) (CD31) is an adhesion molecule believed to mediate transendothelial migration of neutrophils and other leukocytes after CD11/CD18-mediated adhesion. Our study evaluated the role of PECAM-1 in neutrophil emigration across the pulmonary capillaries and the bronchial microvasculature using blocking anti-PECAM-1 antibodies in mice and rats. Neutrophil emigration was induced by Escherichia coli, a stimulus eliciting CD11/CD18-dependent emigration, or Streptococcus pneumoniae, a stimulus inducing CD11/CD18-independent emigration. Although anti-PECAM-1 antibodies partially inhibited glycogen-induced neutrophil emigration into the peritoneum, neutrophil emigration across either the pulmonary capillaries or the bronchial microvasculature in response to either E. coli or S. pneumoniae was not prevented when the function of PECAM-1 was inhibited in either mice or rats. There was also no increase in the number of intravascular neutrophils within the bronchial vessels after treatment with anti-PECAM-1 antibody. These studies indicate that either CD11/CD18-dependent or -independent adhesion pathways may lead to PECAM-1-independent transendothelial migration through the pulmonary or the bronchial endothelium.
Injuries to the triceps surae muscle of elite rugby union front rowers: A qualitative video analysis and 3 dimensional kinematic analysis of the front row during live scrummaging
Creators: name: Flavell, Carol
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2010
Subjects: triceps surae
rugby union
scrummaging
front row

description: The increasing incidence of injury to the triceps surae muscle in high performance front row rugby union players has stimulated a need to investigate the events surrounding this injury. Previous research has linked TS muscle injuries with both scrummaging and activities which mimic those of scrummaging, but the possible mechanisms of injury remain unidentified. In addition, limited published data exists, that has reported the biomechanics of scrummaging techniques of high performance players. Of these studies the majority have been undertaken using scrummaging machines, with research on the biomechanics of live scrummaging less well documented. Accordingly, the purpose of this two part study was firstly to conduct an observational video analysis of TS injuries in a group of high performance front row players, and subsequently investigate the lower limb kinematics of a second cohort of high performance players during a series of live scrummaging drills. It was hypothesised that using mixed method analysis would provide a greater depth of understanding about the possible causes and mechanisms for TS injury.
Functions of IκB proteins in inflammatory responses to Escherichia coli LPS in mouse lungs
Creators: name: Scott, M.L.
name: Mizgerd, J.P.
name: Doerschuk, C.M.
name: Spieker, M.R.
Publisher: name: American Lung Association
Year: 2002

description: Acute inflammation induced by intrapulmonary LPS requires nuclear factor (NF)-κB RelA. This study elucidates the effects of intrapulmonary LPS on IκB proteins, endogenous inhibitors of RelA, and the effects of deficiency of IκB-β. IκB-α, IκB-β, and IκB-ε each complexed with RelA in uninfected murine lungs. Intratracheal instillation of LPS induced the degradation of IκB-α and IκB-β, as measured by the loss of immunoreactive proteins in non-nuclear fractions. Degradation was apparent by 2 h and sustained through 6 h. In contrast, net IκB-ε content increased over this period. The small amounts of IκB-α and IκB-β that were detected in nuclear fractions from the lungs also decreased over this time frame, whereas intranuclear NF-κB content (including both RelA and p50) increased. The hypophosphorylated form of IκB-β, which facilitates transcription induced by NF-κB, was not detected. Neutrophil recruitment and edema accumulation did not differ between wild type mice and gene-targeted mice deficient in IκB-β, suggesting that IκB-β is not specifically required for these responses. Altogether, these data suggest that RelA is liberated during LPS-induced pulmonary inflammation by the regulated degradation of both IκB-α and IκB-β. In the absence of IκB-β, IκB-α or other inhibitory proteins can regulate NF-κB functions essential to acute neutrophil emigration in the lungs.
Environmental justice implications of flood risk in the contiguous United States – a spatiotemporal assessment of flood exposure change from 2001 to 2019
Creators: name: Xu, Jinwen
name: Qiang, Yi
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Plant Biology

description: Flood hazard is one of America’s most frequent and expensive natural hazards and causes enormous economic losses in the United States every year. Flood hazards disproportionately affect marginalized and socioeconomically disadvantaged populations. This disproportionate flood exposure constitutes a form of environmental injustice. Few studies have undertaken a large-scale assessment of the long-term change of flood exposure. To fill this gap, this study utilized land use and flood zone data from 2001 to 2019 at a 5-year interval to analyze spatiotemporal changes in flood exposure in the Contiguous United States (CONUS). Two indices, the Deviational Exposure Index and Socioeconomic Disparity Index, were introduced to measure flood exposure and the socioeconomic disparities associated with flood exposure. At the national level, the overall flood exposure in the CONUS decreased in the past two decades, indicating increasing awareness of flood risk in the country. But the local variations of flood exposure and its changing trends vary among communities. In general, coastal and riverine counties show a general avoidance of developing urban areas in flood zones, while inland counties show an opposite tendency of urban development in floodplains. The results of this study reveal socioeconomic and demographic disparities between communities in and out of flood zones and evaluate environmental injustice among disadvantaged populations. The knowledge learned from this study can not only help address environmental justice issues but also benefit the decision-making of the federal government and local authorities in urban development and smart growth when faced with flood risk.
Lung microvascular and arterial endothelial cells differ in their responses to intercellular adhesion molecule-1 ligation
Creators: name: Stevens, T.
name: Doerschuk, C.M.
name: Wang, Q.
name: Pfeiffer II, G.R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Neutrophil adherence to tumor necrosis factor-α (TNF-α)-treated human pulmonary microvascular endothelial cells (PMECs) induces cytoskeletal changes in endothelial cells that require intercellular adhesion molecule-1 (ICAM-1)-dependent signaling events. This study determined whether similar changes occurred in rat PMECs and whether rat pulmonary arterial endothelial cells (PAECs) responded differently. Neutrophil adherence induced an increase in the formation of F-actin and in the apparent stiffness of TNF-α-treated rat PMECs. These responses, however, were absent in PAECs. To determine the mechanisms underlying these differences, ICAM-1-mediated signaling events were compared. Upregulation of ICAM-1 by TNF-α and redistribution of ICAM-1 induced by cross-linking antibodies were similar in both cell types. However, neutrophil adherence induced production of reactive oxygen species only in PMECs and not in PAECs. Moreover, phosphorylation of p38 mitogen-activated protein kinase induced by ICAM-1 cross-linking occurred only in PMECs and not in PAECs. This increase in p38 phosphorylation in PMECs was inhibited by allopurinol, a xanthine oxidase inhibitor. These data demonstrated that whereas TNF-α upregulated ICAM-1 and ICAM-1 cross-linking induced a similar redistribution of ICAM-1 on the endothelial cell surface, ICAM-1 ligation initiated p38 activation and cytoskeletal rearrangements only in PMECs and not in PAECs. Thus, neutrophil adhesion through ICAM-1 induced signaling events leading to cytoskeletal changes only in PMECs, the site of neutrophil emigration and edema formation, and not in PAECs.
Evolution of a thermal mixing layer in uniformly sheared turbulent flow.
Creators: name: Ferchichi, Mohsen.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1991
Subjects: subject: Engineering, Mechanical.

description: Turbulent mixing and transport are very important phenomena due to their relevance in diverse applications (e.g. turbulent mixers, contamination of oceans and the atmosphere). For a better understanding of these phenomena, an experiment dealing with the development of a thermal mixing layer in uniformly sheared turbulent flow has been conducted. This experiment consists of introducing a stepwise increase in the mean temperature to the flow by electrically heating a set of thin ribbons, spanning half of a wind-tunnel cross-section. Hot wire anemometery and cold wire thermometry were used to measure the means and fluctuations of velocity and temperature. The downstream growth of the thermal mixing layer and the distributions of r.m.s. temperature fluctuations, thermal fluxes and other scalar field statistics are reported. Measurements show that the thermal field reaches a quasi-asymptotic state and that the thermal mixing layer penetrated deeper into the low speed side than into the high speed side of the flow. The study also includes theoretical attempts to predict the layer's growth.
The geochemistry of shocked and country rocks from the Lake Wanapitei impact structure, Ontario.
Creators: name: Ber, Tomasz Jan.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Geophysics.

description: Lake Wanapitei is located in central Ontario, 40 km northeast of Sudbury. The geophysical and morphological evidence suggest that the crater originally measured 8500 m in diameter. The original ground surface has been lowered by some 300 m; material scoured from the crater floor has been deposited as glacial float on and south of the southern shoreline. The shock metamorphosed rock fragments in these deposits consist of glassy melt rocks and suevitic breccias with lithic clasts of mainly quartzite, arkose, wacke, siltstone, and diabase. This work concentrates on establishing a compositional relationship between the Wanapitei crater lithologies and the unshocked country rocks at the area. Due to the relatively young age of the structure, the impact melt glasses are well preserved, with a low content of quench plagioclase and other alterations resulting from devitrification. Presented here are the results of bulk rock XRF and microprobe analyses of the Wanapitei crater rocks together with analyses of country rocks, that may have been exposed to the impact at the time of event. The suspected target rocks are represented by Proterozoic quartzitic sediments of Mississagi, Bruce, and Gowganda Formations, and diabase dikes of Nipissing Intrusions. A least-squares mixing model has been applied to determine which of the country rocks, were mixed to produce the observed impact glass lithologies. The results indicate 56% of Mississagi and 44% of Gowganda Formations; however, secondary evidence suggests a limited contribution of the Nipissing rocks. Based on these results, the meteoritic content of the impact melts has been established, and by comparison of siderophile geochemical data with the Wanapitei samples, a chondrite has been confirmed as the most probable projectile. The grade of shock metamorphism recorded in the Wanapitei shocked rocks suggests at least 65-70 GPa for maximum pressures and up to 2500$\sp\circ$C for maximum temperatures.
The Commodification of Retirement: A Case Study of Active Ageing on the Sunshine Coast, Queensland
Creators: name: Lederbauer, Gerd
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2014
Subjects: commodification
retirement
active ageing

description: This thesis is a qualitative case study of the socio-economic tensions in retirement lifestyle and the retirement village industry. It examines active ageing in the context of one retirement village and analyses village lifestyle in relation to commodification processes pursued by the retirement village industry. Regardless of increased social interactions and opportunities for leisure, physical activities, mental and physical health offered in retirement villages, a focus on health and well-being does not take into account the ways in which these can and have been commodified to financially disadvantage some residents. This study argues that today's retirees are actively encouraged to extend consumption practices into retirement and that active ageing has become a process of continuous spending and consumption. This 'active' retirement lifestyle has resulted in numerous socio-economic changes. For example, the emergence of a corporatized retirement village industry has promoted a new style of independent retirement living, featuring the self-funded, 'one-stop' retirement village. The industry sells village villas/units and is successful because it promotes a 'dream lifestyle'. This thesis argues that this promise incorporates elements of commodification since participation in active ageing activities frequently attracts additional expense. Retirement village residents face both social and economic costs and non-participation entails penalties that may result in exclusion and isolation.
Very late antigen-4 in CD18-independent neutrophil emigration during acute bacterial pneumonia in mice
Creators: name: Doerschuk, C.M.
name: Tasaka, S.
name: Mizgerd, J.P.
name: Richer, S.E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: This study tested the hypothesis that very late antigen (VLA)-4 mediates CD18-independent neutrophil emigration into the air-spaces induced by either Streptococcus pneumoniae, a stimulus that induces primarily CD18-independent neutrophil emigration, or Escherichia coli, toward which only 20-30% of the total number of neutrophils emigrate through CD18-independent pathways. In wild-type (WT) mice, VLA-4 expression was less on neutrophils that emigrated into the airspaces than on circulating neutrophils. Vascular cell adhesion molecule-1 (VCAM-1) mRNA, the major endothelial cell ligand for VLA-4, increased more in E. coli than in S. pneumoniae pneumonia. VCAM-1 protein expression was not detected in capillaries, the major site of neutrophil emigration. Neutrophil emigration during E. coli or S. pneumoniae pneumonia was similar in mice given antibodies against both CD18 and VLA-4 compared with mice given the anti-CD18 antibody and a control antibody. However, in hematopoietically reconstituted mice with both WT and CD18-deficient neutrophils in their blood, the migration of CD18-deficient neutrophils in response to S. pneumoniae was slightly but significantly less in animals pretreated with the anti-VLA-4 antibody than in those receiving a control antibody. These data suggest that VLA-4 plays a small role in CD18-independent neutrophil emigration, but the majority of CD18-independent neutrophil emigration induced by bacteria in the lungs occurs through VLA-4-independent mechanisms.
Supplementary document for Generation of 64-fs L-band stretched pulses from an all-fibre Er-doped laser - 5301765.pdf
Creators: name: Huang, Zinan
name: Boscolo, Sonia
name: Huang, Qianqian
name: Xing, Zhikun
name: Yan, Zhijun
name: Chen, Tao
name: Liu, Yunqi
name: Mou, Chengbo
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: supplement
Ions and neutrals in the gas phase: Structure, stability and fragmentation mechanisms.
Creators: name: Harnish, David.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Chemistry, Physical.

description: Overview. With the advent of two new techniques, collisionally induced dissociative ionization and neutralization reionization mass spectrometry, it is possible to investigate the structure and stability of neutrals as well as ions. Fragmentation mechanisms of alkyl phenyl ethers. The metastable fragmentation mechanisms of alkyl phenyl ethers and methyl pentyl ethers have been thoroughly investigated. It has been shown that the formation of an ion/radical complex is the key step in the metastable loss of olefin from alkyl phenyl ethers and loss of methanol from methyl pentyl ethers. The alkyl moiety in an ion/radical complex between a primary alkyl cation and a phenoxy radical undergoes a rate determining isomerization to a secondary or tertiary alkyl cation at an energy above the dissociation threshold for the resulting complex. A $\beta$(H$\sp+$) is then immediately transferred from the alkyl cation to the phenoxy radical followed by dissociation to products. Assigning structures to isomeric ($\rm C\sb5,H\sb \rbrack\sp{+.}$ ions. The ten (C$\rm\sb5,H\sb \rbrack\sp{+.}$ isomers may be distinguished based on their heats of formation, low ionizing electron energy mass spectra and charge stripping mass spectra. The fragmentation mechanisms for H$\sb2$O loss from 1-pentanol and HCl loss from 1-chloropentane were determined the aid of deuterium labelling and identification of the product (C$\rm\sb5,H\sb \rbrack\sp{+.}$ ions. Collision induced ionization efficiencies of fast neutrals. The O$\sb2$ collisional ionization efficiencies of CO and CH$\sb2$=CH$\sb2$ depend on both the translational and internal energies of the neutral. The ionization efficiencies increased with increasing translational energy from 2000-5200 V as expected for ionization by the electron detachment mechanism. The ionization efficiencies decreased with increasing internal energy. The generation of stable BH$\sb3$ and BH$\sb4\sp-$ in the gas phase. The stability of BH$\sb3$, BH$\sb4$ and their deuterated counterparts BD$\sb3$ and BD$\sb4\sp-$ were studied by neutralization reionization mass spectrometry. (Abstract shortened by UMI.)
How significant is the plant biodiversity of localised patches of heathy vegetation growing on low fertility soils on the hills and ranges and adjacent inland of southern Queensland?
Creators: name: Young, Peter
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2016
Subjects: Northeastern subtropics Australia
heathland
sclerophyllous shrubby ecosystems
endemism
disjunction
persistence
rarity
vegetal patterns
fire
substrate

description: This study investigates the occurrence of scattered patches of fire-prone sclerophyllous shrubby (heathy) vegetation confined to infertile soil landscapes in a geographical area defined by a Köppen Cfa sub-tropical climate. The region extends from the long-recognised McPherson-Macleay Overlap and New England Tableland north-west to the edge of the sandstone massif of the Carnarvon Range on the margins of the semi-arid interior of central-eastern Australia. It lies north of the major occurrence of sclerophyllous shrubby vegetation within eastern Australia. Coastal parts of the region are recognised as supporting a distinctive heath flora known as the "wallum". However the remainder of the area has been largely overlooked as a centre containing a definable sclerophyllous shrubby flora. The overall goal of the investigation, therefore, is to determine the extent and nature of the regional heath-type diversity and to place it within broader biogeographical and ecological contexts.
Tumor necrosis factor receptor 2 contributes to ozone-induced airway hyperresponsiveness in mice
Creators: name: Doerschuk, C.M.
name: Murthy, G.G.K.
name: Shore, S.A.
name: Blanc, B.L.E.
name: Schwartzman, I.N.
Publisher: name: American Lung Association
Year: 2001

description: The purpose of this study was to determine whether tumor necrosis factor (TNF) contributes to airway hyperresponsiveness (AHR) and migration of polymorphonuclear leukocytes (PMN) into the airways following exposure to ozone (03). Wild-type mice, TNF p55 or p75 receptor knockout mice (p55 TNFR -/- and p75 TNFR -/-), as well as double receptor knockout mice (p55/p75 TNFR -/-), were exposed to O3. Three hours after cessation of O3, airway responses to inhaled methacholine were determined by whole body plethysmography using changes in enhanced pause (Penh) as an index of airway narrowing. In wild-type mice, O3 exposure (0.5 ppm, 3 h) caused a significant increase in airway responsiveness as indicated by a 1.2 log leftward shift in the methacholine dose-response curve. In contrast, in p55/p75 TNFR -/- mice, O3 caused only a 0.5 log shift in the dose-response curve (p < 0.05 compared with wild-type). Similar results were obtained in p75 TNFR -/mice. In contrast, O3-induced airway hyperresponsiveness was not different in WT and p55 TNFR -/- mice. During O3 exposure (1 pm, 3 h), minute ventilation (V̇e) decreased by 64 ± 4% in wild-type, but only 24 ± 5% in p55/p75 TNFR -/- mice, indicating that despite their reduced O3-induced AHR, the TNFR-deficient mice actually inhaled a greater dose of O3. Similar results were obtained in p75 -/- mice, whereas changes in V̇e induced by O3 were the same in wild-type and p55 -/- mice. PMN numbers in bronchoalveolar lavage fluid recovered 21 h after cessation of exposure to O3 (2 ppm, 3 h) were significantly increased compared with after air exposure but were not different in wild-type and p55/p75 TNFR -/- mice. Our results indicate that TNF contributes to the AHR but not the PMN emigration induced by acute O3 exposure.
Advancing the use of Digital Game-Play in Primary and Secondary School Classrooms to Establish Supportive and Engaging Classroom Learning Environments
Creators: name: Stieler-Hunt, Colleen
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2016
Subjects: games-based learning
elementary education
serious games
video games
educational beliefs
pedagogical issues
game design

description: Digital games have been used sporadically in classrooms since the 1970s, but their adoption rate continues to be low. Researchers have identified a number of benefits of using digital games in the curriculum including deep engagement, improving social skills, and offering opportunities for higher order thinking. However, there are significant barriers to their use in classrooms such as access to appropriate hardware and software, teacher's knowledge of games and how to effectively use them in a classroom environment, negative societal attitudes towards digital games, and difficulties matching digital games to curricula. Many of the digital games created for classroom use are short form drill-and-practice games that focus on learning through repetition and only offer lower levels of learning. These games are not the type of ames students would choose to play at home and may fail to meet learner expectations. Gradually, more complex digital learning games are being created by game designers. However, designers are still learning the best ways to make the most of the affordances offered by the classroom environment. This thesis offers new insights into the experiences of teachers who choose to use digital games in their classrooms and makes recommendations on the design of digital learning games.
Exposure to baby-friendly hospital practices and mothers’ achievement of their planned duration of breastfeeding
Creators: name: Lok, Kris Y W
name: Chow, Charlotte L Y
name: Fan, Heidi S L
name: Chan, Vincci H S
name: Tarrant, Marie
Publisher: name: BioMed Central
Year: 2020

description: Background: Both breastfeeding intentions and exposure to baby-friendly hospital practices were found to be associated with a longer duration of breastfeeding. This study aims to examine the effect of exposure to baby-friendly hospital practices on mothers’ achievement of their planned duration of breastfeeding. Methods: A total of 1011 mother-newborn pairs from the postnatal units of four public hospitals in Hong Kong were recruited. Sociodemographic data and breastfeeding intention data were collected via self-report questionnaires during the postnatal hospitalization and exposure to Baby-Friendly hospital practices were assessed through hospital records and maternal self-report. Breastfeeding status after hospital discharge was assessed through telephone follow-up for up to 12 months postnatal, or until participants were no longer breastfeeding. Results: Only 55% (n = 552) of study participants achieved their intended duration of breastfeeding. Participants with higher socioeconomic status, previous breastfeeding experience, and those who had lived in Hong Kong for less than 5 years, were more likely to achieve their planned duration of breastfeeding. Among baby-friendly hospital practices, feeding only breast milk during the hospitalization and providing information about breastfeeding support on discharge were associated with participants’ achieving their individual breastfeeding intentions. After adjustment, when compared with women who experienced onebaby-friendly practice, participants who experienced six baby-friendly hospital practices were significantly more likely to achieve their planned duration of breastfeeding (adjusted odds ratio = 8.45, 95% confidence interval 3.03–23.6). Conclusions: Nearly half of participants did not achieve their planned breastfeeding duration. Exposure to baby-friendly hospital practices, especially in-hospital exclusive breastfeeding and providing breastfeeding support information upon hospital discharge may help more mothers to achieve their individual breastfeeding goals.
The effect of recovery duration on muscle oxygenation, heart rate, perceived exertion, time motion descriptors, and technical proficiency during small sided games of football
Creators: name: McLean, Scott
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2015
Subjects: football
small sided games
NIRS
recovery
pacing

description: This thesis was comprised of two research studies. The common component was the change in the duration of the recovery periods separating the SSG bouts, with the first study based on the physiological components of the SSG, and the second study based on the technical skill components of the SSG. The data for both studies were collected from the same participant group.
Caspase 3 Cleavage of Pax7 Inhibits Self-Renewal of Satellite Cells
Creators: name: Dick, Sarah
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015

description: Compensatory growth and regeneration of skeletal muscle is dependent on the resident stem cell population, termed satellite cells. Self-renewal and maintenance of the satellite cell niche is coordinated by the transcription factor Pax7, yet continued expression of this protein inhibits the myoblast differentiation program. As such, the reduction or removal of Pax7 may denote a key prerequisite for satellite cells to abandon self-renewal and acquire differentiation competence. Here, we identify caspase 3 cleavage inactivation of Pax7 as a crucial step for terminating the self-renewal process. Inhibition of caspase 3 results in elevated Pax7 protein and satellite cell self-renewal, while caspase activation leads to Pax7 cleavage and initiation of the myogenic differentiation program. We have also noted that casein kinase 2 (CK2) directed phosphorylation of Pax7 attenuates caspase directed cleavage. Together, these results demonstrate that satellite cell fate is dependent on opposing post-translational modifications of the Pax7 protein.
Queerly Ever After: An Exploration of Fairy Tales through a Plurisexual Lens
Creators: name: Cole, Alayna M
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2018
Subjects: queer
representation
diversity
fairy tales
coming out stories

description: The conventions of the European fairy tale canon-comprising the traditional European literary works of Charles Perrault, Jacob and Wilhelm Grimm, and Hans Christian Andersen-perpetuate heteropatriarchal ideals. These limit the ability of readers with diverse sexualities and genders to form understandings of their own identity and place within Western society, while simultaneously contributing to societal attitudes that negatively impact on the queer community. Though some works have made attempts to subvert these heteropatriarchal conventions-such as feminist and queer reimaginings of the European fairy tale canon-there has typically been an emphasis on representing monosexual characters and behaviours, with few existing tales exploring the fluidity of sexuality and gender, and the possibility for plurisexual identities that this reveals. Queerly Ever After is a collection of interlinked short stories constructed to form a greater understanding of representations of plurisexuality, particularly in ways that can expose and challenge heteropatriarchal conventions typical of the European fairy tale canon. The accompanying exegesis has been used to contextualise the creative artefact within existing works and academic discourse. This research, conducted under the candidature of a Doctor of Creative Arts (Creative Writing) seeks to address three key research aims: firstly, this research explores the genre conventions of the European fairy tale canon through the existing work of academics such as Jack Zipes and Elizabeth Harries, and highlights the heteropatriarchal representations within these texts; secondly, this work examines existing queer fairy tales and compares their attempts to subvert genre conventions to the feminist fairy tales that challenge patriarchal structures; and lastly, through the construction of Queerly Ever After, the research establishes how one can consciously select conventions of the European fairy tale canon, queer fairy tales, coming out stories, and feminist fairy tales to adhere to and/or subvert, with the purpose of representing and empowering diverse plurisexual women and their identities.
Regulating Performance Based Mentality: A Metacognitive Development
Creators: name: Love, Steven
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2019
Subjects: metacognition
self-regulation
state anxiety
flow state
attention
sports
athletes
performance
beliefs

description: Metacognition, or experiencing cognition about cognition, has been evidenced to have strong associations with to the way attention, information, and emotions are regulated. However, to date, little research has investigated how metacognitive concepts may apply to a sporting context, which is heavily dependent on the regulation of such phenomena. Therefore, the primary aims of this thesis were to: (a) investigate whether metacognitions were significantly associated with sports related mental states; (b) develop appropriate sports specific measurements of metacognitions; and (c) investigate the associations between sports specific metacognitions with sports related mental states. A literature review, five empirical studies, and a discussion piece were designed for this purpose. The first study evaluated how competitive triathletes' metacognitive beliefs associated with competitive state anxiety, concentration, and performance. It also examined differences in metacognitive beliefs across cross-sectional time-to-event intervals. The second study examined how triathletes' metacognitions relate to mindfulness and the different dimensions of flow during competition. It also assessed at how these factors differed across motivational types (i.e., recreational; social; competitive). The purpose of the third and fourth studies was to develop and validate two self-report questionnaires measuring sport specific metacognitive beliefs and processes, based on previous literature and findings of the previous studies. Additionally, the studies investigated the contributions that these measures had towards psychological outcomes, such as: state anxiety, cognitive flexibility, and concentration. The fifth study aimed to extend the results from the second study, by investigating the associations between the sports specific metacognitive questionnaires, with flow state. The proceeding discussion chapter, evaluated the results of these studies in whole, presented a proposed metacognitive model of performance, discussed potential implications of the findings towards enhancing athletic performance, and suggested areas of focus for future research.
Entre la vie et la mort : processus décisionnel afin de retirer le ventilateur à titre de traitement pour laisser mourir un individu
Creators: name: Chartrand, Louise
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: Théorie d'acteur en réseau
Ventilateur
Thérapeute respiratoire (RRT)
Réflexivité
Laisser mourir
Euthanasie

description: Bien que la technologie médicale a largement contribué à améliorer la qualité ainsi qu’à augmenter la longévité humaine, celle-ci est aussi responsable d’avoir créé de nouvelles responsabilités difficiles. En effet, il est maintenant de notre responsabilité d’un côté de choisir si on désire faire appel à la technologie afin de prolonger la vie et d’un autre côté choisir le moment quand celle-ci devrait être retirée et de « laisser mourir ». Quand est-il approprié de venir à cette conclusion? Comment y arrive-t-on? Nous proposons, à travers la description du processus décisionnel afin de retirer le ventilateur à titre de traitement pour laisser mourir un individu, d’explorer le rôle des différents acteurs impliqués. Ceci est accompli en suivant la perspective de la théorie des acteurs en réseau jumelé à la méthode de la réflexivité institutionnelle, expérientielle et des savoirs. Notre expérience comme thérapeute respiratoire a été centrale afin de décrire le réseau qui se forme lorsque le processus décisionnel afin de retirer le ventilateur pour laisser mourir quelqu’un se produit.
CD11/CD18-Dependent and -independent neutrophil emigration in the lungs: How do neutrophils know which route to take?
Creators: name: Wang, Q.
name: Tasaka, S.
name: Doerschuk, C.M.
Publisher: name: American Lung Association
Year: 2000

description: Neutrophil adhesion to pulmonary microvascular endothelial cells and migration into the distal air spaces of the lungs occur through at least two adhesion pathways: one that requires the leukocyte adhesion complex, CD11/CD18, and one that does not (1–10). Which pathway is selected appears to depend on the stimulus. The role of CD11/CD18 has been primarily established through the use of antibodies to block the function of this molecule. Neutrophil emigration in response to Escherichia coli, E. coli lipopolysaccharide (LPS), Pseudomonas aeruginosa, immunoglobulin (Ig)G immune complexes, interleukin (IL)-1, and phorbol myristate acetate occurs through adhesion pathways that require CD11/CD18 (1–7). In contrast, Streptococcus pneumoniae, Group B Streptococcus, Staphylococcus aureus, hyperoxia, C5a, and hydrochloric acid elicit neutrophil emigration through pathways not inhibited, despite blockade of the CD11/CD18 adhesion complex (1–10). Even when stimuli elicit emigration primarily through CD18-dependent pathways, anti-CD18 antibodies block neutrophil emigration by only 60 to 80%, leaving about 20 to 40% of neutrophils emigrating through CD18-independent pathways. An autopsy report of a child with complete deficiency of CD11/CD18 (leukocyte adhesion deficiency, type I) showed neutrophils and monocytes within the alveoli and small airways (11), suggesting that human neutrophils, as well as those of mice and rats, can use CD11/CD18-independent mechanisms of neutrophil emigration.
Evaluation von Klimavorsorgediensten
Creators: name: Kaiser, Theresa
name: Kind, Christian
name: Kern, Natalie
Publisher: name: Umweltbundesamt
Year: 2022
Subjects: subject: Anpassung an den Klimawandel
subject: Folgen des Klimawandels
subject: Bewertung
subject: Wirkung
subject: Klimaanpassung
subject: Klimavorsorgedienste
subject: Klimafolgen
subject: Evaluation
subject: Hitzeaktionsplan
subject: Klimavorsorgeportal
subject: KLiVO
subject: Klima | Energie
subject: Gesundheit
subject: Nachhaltigkeit | Strategien | Internationales

description: Die Handreichung enthält praktische Hinweise und Methoden zur Evaluation von Klimavorsorgediensten. Neben den zentralen Ebenen eines Wirkungsmodells sowie Leitfragen einer Evaluation werden insbesondere Methoden zur Datenerhebung und Analyse vorgestellt, mit denen ein Einstieg in die Evaluation gelingen kann. Die Handreichung richtet sich an Anbieter von Klimadiensten, Klimaanpassungsdiensten oder Klimavorsorgediensten, die u.a. auf dem Deutschen Klimavorsorgeportal (KLiVO Portal, www.klivoportal.de) zur Verfügung gestellt werden. Quelle: www.umweltbundesamt.de
description: Die Handreichung enthält praktische Hinweise und Methoden zur Evaluation von Klimavorsorgediensten. Neben den zentralen Ebenen eines Wirkungsmodells sowie Leitfragen einer Evaluation werden insbesondere Methoden zur Datenerhebung und Analyse vorgestellt, mit denen ein Einstieg in die Evaluation gelingen kann.Die Handreichung richtet sich an Anbieter von Klimadiensten, Klimaanpassungsdiensten oder Klimavorsorgediensten, die u.a. auf dem Deutschen Klimavorsorgeportal (KLiVO Portal, www.klivoportal.de) zur Verfügung gestellt werden.
Spatio-Temporal Theory of Optical Kerr Nonlinear Instability
Creators: name: Nesrallah, Michael J.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Nonlinear Optics
Kerr Nonlinearity
Light-Matter Interaction
Modulation Instability
Filamentation Instability
Kerr Amplification
Perturbation
Instability Analysis
Maxwell's Equations
Spatio-Temporal

description: This work derives a nonlinear optical spatio-temporal instability. It is a perturbative analysis that begins from Maxwell’s equations and its constituent relations to derive a vectorial nonlinear wave equation. In fact, it is a new theoretical method that has been developed that builds on previous aspects of nonlinear optics in a more general way. The perturbation in the wave equation derived is coupled with its complex conjugate which has been taken for granted so far. Once decoupled it gives rise to a second-order equation and thus a true instability regime because the wavevector can become complex. The solution obtained for the perturbation that co-propagates with the driving laser is a generalization to modulation and filamentation instability, extending beyond the nonlinear Schrodinger and nonlinear transverse diffusion equations[1][2]. As a result of this new mechanism, new phenomena can be explored. For example, the Kerr Nonlinear Instability can lead to exponential growth, and hence amplification. This can occur even at wavelengths that are typically hard to operate at, such as into far infrared wave- lengths. This provides a mechanism for obtaining amplification in the far infrared from a small seed pulse without the need for population inversion. The analysis provides the basic framework that can be extended to many different avenues. This will be the subject of future work, as outlined in the conclusion of this thesis.
Leukocyte trafficking in alveoli and airway passages
Creators: name: Doerschuk, C.M.
Publisher: name: BioMed Central Ltd.
Year: 2000

description: Many pulmonary diseases preferentially affect the large airways or the alveoli. Although the mechanisms are often particular to each disease process, site-specific differences in leukocyte trafficking and the regulation of inflammation also occur. Differences in the process of margination, sequestration, adhesion, and migration occur that can be attributed to differences in anatomy, hemodynamics, and the expression of proteins. The large airways are nourished by the bronchial circulation, whereas the pulmonary circulation feeds the distal lung parenchyma. The presence of different cell types in large airways from those in alveoli might contribute to site-specific differences in the molecular regulation of the inflammatory process.
Machine learning approaches to predict peak demand days of cardiovascular admissions considering environmental exposure
Creators: name: Qiu, Hang
name: Luo, Lin
name: Su, Ziqi
name: Zhou, Li
name: Wang, Liya
name: Chen, Yucheng
Publisher: name: BioMed Central
Year: 2020

description: Background: Accumulating evidence has linked environmental exposure, such as ambient air pollution and meteorological factors, to the development and severity of cardiovascular diseases (CVDs), resulting in increased healthcare demand. Effective prediction of demand for healthcare services, particularly those associated with peak events of CVDs, can be useful in optimizing the allocation of medical resources. However, few studies have attempted to adopt machine learning approaches with excellent predictive abilities to forecast the healthcare demand for CVDs. This study aims to develop and compare several machine learning models in predicting the peak demand days of CVDs admissions using the hospital admissions data, air quality data and meteorological data in Chengdu, China from 2015 to 2017. Methods: Six machine learning algorithms, including logistic regression (LR), support vector machine (SVM), artificial neural network (ANN), random forest (RF), extreme gradient boosting (XGBoost), and light gradient boosting machine (LightGBM) were applied to build the predictive models with a unique feature set. The area under a receiver operating characteristic curve (AUC), logarithmic loss function, accuracy, sensitivity, specificity, precision, and F1 score were used to evaluate the predictive performances of the six models. Results: The LightGBM model exhibited the highest AUC (0.940, 95% CI: 0.900–0.980), which was significantly higher than that of LR (0.842, 95% CI: 0.783–0.901), SVM (0.834, 95% CI: 0.774–0.894) and ANN (0.890, 95% CI: 0.836–0.944), but did not differ significantly from that of RF (0.926, 95% CI: 0.879–0.974) and XGBoost (0.930, 95% CI: 0.878–0.982). In addition, the LightGBM has the optimal logarithmic loss function (0.218), accuracy (91.3%), specificity (94.1%), precision (0.695), and F1 score (0.725). Feature importance identification indicated that the contribution rate of meteorological conditions and air pollutants for the prediction was 32 and 43%, respectively. Conclusion: This study suggests that ensemble learning models, especially the LightGBM model, can be used to effectively predict the peak events of CVDs admissions, and therefore could be a very useful decision-making tool for medical resource management.
title: Adrenal haemangioma: An uncommon incidental finding
Creators: name: Alfonso Cerdán, Sheila
Publisher: name: EURORAD
Year: 2024
Subjects: subject: Abdominal imaging
subject: Abdomen
subject: Retroperitoneum
subject: CT
subject: Haemangioma
subject: Pathology
subject: Clinical Case

description: Clinical History: A 66-year-old asymptomatic male, without significant medical or familial history, was diagnosed with rectal adenocarcinoma during a routine screening program. The diagnosis followed a positive faecal occult blood test, leading to a colonoscopy. Laboratory findings were within normal limits, and the patient had no history of hypertension, dyslipidaemia, or diabetes.

description: 66 years, male