cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Figure S13 from Comparative genomic analysis of the ‘psuedofungus’ Hyphochytrium catenoides.
Creators: name: Leonard, Guy
name: Labarre, Aurélie
name: Milner, David S.
name: Monier, Adam
name: Soanes, Darren
name: Wideman, Jeremy G.
name: Maguire, Finlay
name: Stevens, Sam
name: Sain, Divya
name: Grau-Bove, Xavier
name: Arnau Sebe-Pedros
name: Stajich, Jason E.
name: Paszkiewicz, Konrad
name: Brown, Matthew W.
name: Hall, Neil
name: Wickstead, Bill
name: Richards, Thomas A.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 60408 Genomics
subject: FOS: Biological sciences

description: Eukaryotic microbes have three primary mechanisms for obtaining nutrients and energy: phagotrophy, photosynthesis and osmotrophy. Traits associated with the latter two functions arose independently multiple times in the eukaryotes. Fungi successfully coupled osmotrophy with filamentous growth, similar traits are also manifested in the Pseudofungi (oomycetes and hyphochytriomycetes). Both the Fungi and the Pseudofungi encompass a diversity of plant and animal parasites. Genome-sequencing efforts have focused on host-associated microbes (mutualistic symbionts or parasites), providing limited comparisons with free-living relatives. Here we report the first draft genome sequence of a hyphochytriomycete ‘pseudofungus’; Hyphochytrium catenoides. Using phylogenomic approaches, we identify genes of recent viral ancestry, with related viral derived genes also present on the genomes of oomycetes, suggesting a complex history of viral coevolution and integration across the Pseudofungi. H. catenoides has a complex life cycle involving diverse filamentous structures and a flagellated zoospore with a single anterior-tinselate flagellum. We use genome comparisons, drug sensitivity analysis and high-throughput culture arrays to investigate the ancestry of oomycete/pseudofungal characteristics and metabolic traits, demonstrating that many of the genetic features associated with pathogenic traits evolved specifically within the oomycete radiation. Comparative genomics also identified differences in the repertoire of genes associated with filamentous growth between the Fungi and the Pseudofungi, including differences in vesicle trafficking systems, cell-wall synthesis pathways and motor protein repertoire, demonstrating that unique cellular systems underpinned the convergent evolution of filamentous osmotrophic growth in these two eukaryotic groups.
MOSSOS D´ESQUADRA. TEST PSICOTECNICS, DE PERSONALITAT I L' ENTREVISTA ePub gratis
Creators: name: Riddick
Publisher: name: Zenodo
Year: 2024

description: MOSSOS D´ESQUADRA. TEST PSICOTECNICS, DE PERSONALITAT I L' ENTREVISTA de ROCIO CLAVIJO GAMERO

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MOSSOS D´ESQUADRA. TEST PSICOTECNICS, DE PERSONALITAT I L' ENTREVISTA

ROCIO CLAVIJO GAMERO

Número de páginas: 516

Idioma: CATALÁN

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788414232811

Editorial: MAD

Año de edición: 2019

 

 

 

 

 

Buenos libros descargados MOSSOS D´ESQUADRA. TEST PSICOTECNICS, DE PERSONALITAT I L' ENTREVISTA

 

Overview
(2812) Florence Mann
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 8 of Oral health-related quality of life in 4–16-year-olds with and without juvenile idiopathic arthritis
Creators: name: Gil, Elisabeth G.
name: Skeie, Marit S.
name: Halbig, Josefine
name: Jönsson, Birgitta
name: Lie, Stein Atle
name: Rygg, Marite
name: Fischer, Johannes
name: Rosén, Annika
name: Bletsa, Athanasia
name: Luukko, Keijo
name: Shi, Xie-Qi
name: Frid, Paula
name: Cetrelli, Lena
name: Tylleskär, Karin
name: Rosendahl, Karen
name: Åstrøm, Anne N.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 8. Table S1. Discriminant validity of the Early Childhood Oral Health Impact Scale (ECOHIS) and Child Oral Impacts on Daily Performances (Child-OIDP) according to the global measures and group affiliation.
IGF binding protein 3 exerts its ligand-independent action by antagonizing BMP in zebrafish embryos
Creators: name: Zhong, Yingbin
name: Zhou, Jianfeng
name: Li, Yun
name: Clemmons, David R.
name: Duan, Cunming
name: Lu, Ling
name: Liu, Yunzhang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: IGFBP3 is a multi-functional protein that has IGF-dependent and IGF-independent actions in cultured cells. Here we show that the IGF binding domain (IBD), nuclear localization signal (NLS) and transactivation domain (TA) are conserved and functional in zebrafish Igfbp3. The in vivo roles of these domains were investigated by expression of Igfbp3 and its mutants in zebrafish embryos. Igfbp3, and its NLS and TA mutants had equally strong dorsalizing effects. Human IGFBP3 had similar dorsalizing effects in zebrafish embryos. The activities of IBD and IBD+NLS mutants were lower, but they still caused dorsalization. Thus, the IGF-independent action of Igfbp3 is not related to NLS or TA in this in vivo model. We next tested the hypothesis that Igfbp3 exerts its IGF-independent action by affecting Bmp signaling. Co-expression of Igfbp3 with Bmp2b abolished Bmp2b-induced gene expression and inhibited its ventralizing activity. Biochemical assays and in vitro experiments revealed that IGFBP3 bound BMP2 and inhibited BMP2-induced Smad signaling in cultured human cells. In vivo expression of Igfbp3 increased
PDF [DOWNLOAD] The Genesis 6 Conspiracy Part II: How Understanding Prehistory and Giants Helps Define End-Time Prophecy by Gary Wayne on Iphone
Creators: name: Walsh
Publisher: name: Zenodo
Year: 2024

description: The Genesis 6 Conspiracy Part II: How Understanding Prehistory and Giants Helps Define End-Time Prophecy by Gary Wayne

 

 

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The Genesis 6 Conspiracy Part II: How Understanding Prehistory and Giants Helps Define End-Time Prophecy

Gary Wayne

Page: 768

Format: pdf, ePub, mobi, fb2

ISBN: 9781632696083

Publisher: Deep River Books Llc

 

Ebooks free download for ipad The Genesis 6 Conspiracy Part II: How Understanding Prehistory and Giants Helps Define End-Time Prophecy iBook FB2 CHM (English Edition) 9781632696083

Overview

As was graphically described in the first Genesis 6 Conspiracy book, there are giants among us, passing largely unnoticed, intent on carrying out a secret plan to enslave all humanity. They may not look like giants today, but their bloodlines and DNA extend all the way back to the Nephilim—the offspring of angels who mated with human women—described in Genesis 6 when Giants were roaming the land. Now, in this new work, The Genesis 6 Conspiracy Part II, author Gary Wayne goes in-depth with new information and explanations for each premise laid out in the first book. By adding this fact-filled book to your understanding, you will be able to clearly understand and articulate how we are living in the End of Time. “I was convinced I would not write a sequel to The Genesis 6 Conspiracy,” Wayne said. “So, what swayed my mindset? What I did not perceive was the level of Scriptural angst not appeased by modern clergy, teachers, and leaders in most Christian churches—whether Catholic or Protestant—that, and the thousands of emails I received from those who read the first Genesis 6 Conspiracy book.” This book was written to help answer the lingering questions many Christians have, and to provide scripturally researched answers and data points for these questions. The Genesis 6 Conspiracy Part II explores Scripture's accounting of prehistory, history, and its important prophetic connections and explains in laymen's terms how it all fits together in deciphering the End of Time.
(2813) Michael John Sayer
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
DOWNLOAD [PDF] {EPUB} It Was You All Along by Russ
Creators: name: Su
Publisher: name: Zenodo
Year: 2024

description: It Was You All Along by Russ

 

 

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It Was You All Along

Russ

Page: 208

Format: pdf, ePub, mobi, fb2

ISBN: 9780063357884

Publisher: HarperCollins

 

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Additional file 9 of Oral health-related quality of life in 4–16-year-olds with and without juvenile idiopathic arthritis
Creators: name: Gil, Elisabeth G.
name: Skeie, Marit S.
name: Halbig, Josefine
name: Jönsson, Birgitta
name: Lie, Stein Atle
name: Rygg, Marite
name: Fischer, Johannes
name: Rosén, Annika
name: Bletsa, Athanasia
name: Luukko, Keijo
name: Shi, Xie-Qi
name: Frid, Paula
name: Cetrelli, Lena
name: Tylleskär, Karin
name: Rosendahl, Karen
name: Åstrøm, Anne N.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 9. Table S1. Group affiliation, socio-behavioral, and clinical characteristics in relation to the outcome variable Early Childhood Oral Health Impact Scale (ECOHIS) total score and Child Oral Impacts on Daily Performance (Child-OIDP) simple count (SC) score. Unadjusted and adjusted negative binominal regressions.
SOSP-FR Survey questionnaire
Creators: name: , Charrier
name: Béchec, Le
Publisher: name: Zenodo
Year: 2020
Subjects: open science;questionnaire;digital tools; survey

description: Questionnaire from the SOSP-FR survey conducted by the Lyon URFIST and elaborated by Claire Denecker, Library Conservator, University of Lyon, Lyon URFIST, Philippe Charrier, Research Engineer, University of Lyon, Lyon URFIST,
 Gabriel Gallezot, Senior Lecturer, Université Côte d'Azur, URFIST Méditerranée, Aline Bouchard, Curator of Libraries, École des Chartes, URFIST Paris, Stéphanie Rennes, Engineer, INRAE, Doctoral student, University of Strasbourg.eng
Myosin-X: a MyTH-FERM myosin at the tips of filopodia
Creators: name: Cheney, Richard E.
name: Kerber, Michael L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Myosin-X (Myo10) is an unconventional myosin with MyTH4-FERM domains that is best known for its striking localization to the tips of filopodia and its ability to induce filopodia. Although the head domain of Myo10 enables it to function as an actin-based motor, its tail contains binding sites for several molecules with central roles in cell biology, including phosphatidylinositol (3,4,5)-trisphosphate, microtubules and integrins. Myo10 also undergoes fascinating long-range movements within filopodia, which appear to represent a newly recognized system of transport. Myo10 is also unusual in that it is a myosin with important roles in the spindle, a microtubule-based structure. Exciting new studies have begun to reveal the structure and single-molecule properties of this intriguing myosin, as well as its mechanisms of regulation and induction of filopodia. At the cellular and organismal level, growing evidence demonstrates that Myo10 has crucial functions in numerous processes ranging from invadopodia formation to cell migration.
An essential role for a mammalian SWI/SNF chromatin-remodeling complex during male meiosis
Creators: name: Kim, Yuna
name: Fedoriw, Andrew M.
name: Magnuson, Terry
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Germ cell development and gametogenesis require genome-wide transitions in epigenetic modifications and chromatin structure. These changes include covalent modifications to the DNA and histones as well as remodeling activities. Here, we explore the role of the mammalian SWI/SNF chromatin-remodeling complex during spermatogenesis using a conditional allele of the ATPase subunit, brahma-related gene 1 (Brg1, or Smarca4). Not only do BRG1 levels peak during the early stages of meiosis, genetic ablation of Brg1 in murine embryonic gonocytes results in arrest during prophase of meiosis I. Coincident with the timing of meiotic arrest, mutant spermatocytes accumulate unrepaired DNA and fail to complete synapsis. Furthermore, mutant spermatocytes show global alterations to histone modifications and chromatin structure indicative of a more heterochromatic genome. Together, these data demonstrate a requirement for BRG1 activity in spermatogenesis, and suggest a role for the mammalian SWI/SNF complex in programmed recombination and repair events that take place during meiosis.
Read [Pdf]> 1999: Victory Without War by Richard Nixon
Creators: name: Lewis
Publisher: name: Zenodo
Year: 2024

description: 1999: Victory Without War by Richard Nixon

 

 

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1999: Victory Without War

Richard Nixon

Page: 336

Format: pdf, ePub, mobi, fb2

ISBN: 9781476731773

Publisher: Simon & Schuster

 

Google book downloader for iphone 1999: Victory Without War English version 9781476731773 by Richard Nixon

Overview

“Nixon raises all the timely questions about the present state of the world, and then answers them both systematically and thoroughly.” —The New York Times In this acclaimed national bestseller, Richard Nixon offers a comprehensive strategy for the West—a vital plan of action that will help ensure peace, prosperity, and freedom in the next century. From glasnost and summitry...
Figure S15 from Comparative genomic analysis of the ‘psuedofungus’ Hyphochytrium catenoides
Creators: name: Leonard, Guy
name: Labarre, Aurélie
name: Milner, David S.
name: Monier, Adam
name: Soanes, Darren
name: Wideman, Jeremy G.
name: Maguire, Finlay
name: Stevens, Sam
name: Sain, Divya
name: Grau-Bove, Xavier
name: Arnau Sebe-Pedros
name: Stajich, Jason E.
name: Paszkiewicz, Konrad
name: Brown, Matthew W.
name: Hall, Neil
name: Wickstead, Bill
name: Richards, Thomas A.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 60408 Genomics
subject: FOS: Biological sciences

description: Eukaryotic microbes have three primary mechanisms for obtaining nutrients and energy: phagotrophy, photosynthesis and osmotrophy. Traits associated with the latter two functions arose independently multiple times in the eukaryotes. Fungi successfully coupled osmotrophy with filamentous growth, similar traits are also manifested in the Pseudofungi (oomycetes and hyphochytriomycetes). Both the Fungi and the Pseudofungi encompass a diversity of plant and animal parasites. Genome-sequencing efforts have focused on host-associated microbes (mutualistic symbionts or parasites), providing limited comparisons with free-living relatives. Here we report the first draft genome sequence of a hyphochytriomycete ‘pseudofungus’; Hyphochytrium catenoides. Using phylogenomic approaches, we identify genes of recent viral ancestry, with related viral derived genes also present on the genomes of oomycetes, suggesting a complex history of viral coevolution and integration across the Pseudofungi. H. catenoides has a complex life cycle involving diverse filamentous structures and a flagellated zoospore with a single anterior-tinselate flagellum. We use genome comparisons, drug sensitivity analysis and high-throughput culture arrays to investigate the ancestry of oomycete/pseudofungal characteristics and metabolic traits, demonstrating that many of the genetic features associated with pathogenic traits evolved specifically within the oomycete radiation. Comparative genomics also identified differences in the repertoire of genes associated with filamentous growth between the Fungi and the Pseudofungi, including differences in vesicle trafficking systems, cell-wall synthesis pathways and motor protein repertoire, demonstrating that unique cellular systems underpinned the convergent evolution of filamentous osmotrophic growth in these two eukaryotic groups.
(2814) Alison May Sayer
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Theoretical status of $B \to K^* μ^+μ^-$: The path towards New Physics
Creators: name: Descotes-Genon, Sebastien
name: Hofer, Lars
name: Matias, Joaquim
name: Virto, Javier
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We summarize the status of the analysis of the 4-body angular distribution $B \to K^*(\to K π) μ^+μ^-$ using a basis of optimized observables. We provide a New Physics interpretation of the pattern of deviations observed in the 1fb$^{-1}$ dataset with the coefficient of the semileptonic operator $O_9$ being the main responsible for this pattern. Also other scenarios involving more Wilson coefficients are briefly discussed. Further, we present a detailed description of each of the hadronic uncertainties entering our predictions and suggest possible tests for alternative hadronic explanations. Our most accurate SM predictions for the optimized observables in various bins including all uncertainties are also provided.
description: 17 pages, 1 figure. Talk given at the Discrete 2014: Fourth Symposium on Prospects in the Physics of Discrete Symmetries
M’illumino di meno e le visite guidate a lume di candela al Museo La Specola dell’Osservatorio di Padova
Creators: name: ZANINI, Valeria
name: ZAGGIA, Simone
Publisher: name: O.A. Padova
Year: 2023

description: Dal 2008 l'Osservatorio Astronomico di Padova ha aderito all’evento "M’Illumino di Meno", promosso dalla trasmissione radiofonica Caterpillar di RAI-RADIO2 per favorire la cultura del risparmio energetico, spegnendo computer, luci e riscaldamento per tutto il fine settimana nel quale si svolge l’iniziativa. Dal 2013 si è deciso di partecipare più attivamente, coinvolgendo direttamente il Museo La Specola, sezione museale dell’Osservatorio. In quell’occasione, per la prima volta, sono state organizzate delle speciali visite guidate ‘a lume di candela’ e di torcia elettrica, che hanno riscosso un grandissimo successo. Le visite ‘a lume di candela’ sono state riproposte, anche in occasioni diverse da M’illumino di meno, fino al 2019. Sospese nel 2020 a causa della pandemia, ad oggi non è ancora stato possibile riattivarle dal momento che i Protocolli MAB di accesso alle strutture museali INAF continuano ad essere molto restrittivi e non consentono di ripristinare le attività di visita nelle stesse modalità pre-pandemiche.
[PDF/Kindle] La chronique des Bridgerton Tome 9 by Julia Quinn, Léonie Speer, Cécile Desthuilliers
Creators: name: Wilson
Publisher: name: Zenodo
Year: 2024

description: La chronique des Bridgerton Tome 9 pan Julia Quinn, Léonie Speer, Cécile Desthuilliers

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Caractéristiques

La chronique des Bridgerton Tome 9

Julia Quinn, Léonie Speer, Cécile Desthuilliers

Nb. de pages: 544

Format: Pdf, ePub, MOBI, FB2

ISBN: 9782290380659

Editeur: J'ai lu

Date de parution: 2022

 

 

 

Manuel gratuit à télécharger La chronique des Bridgerton Tome 9 DJVU FB2 in French 9782290380659

 

Overview

Du mariage d'Edmund Bridgerton et de Violet Ledger sont nés huit enfants, héros de La chronique des Bridgerton. Mais que sont devenus Daphné, Anthony, Benedict, Colin, Eloïse, Francesca, Gregory et Hyacinthe, des années plus tard ? Sous le regard bienveillant de lady Violet, la famille se réunit de nouveau. Vous souvenez-vous de lady Whistledown, dont les chroniques alimentaient les ragots du Tout-Londres ? Pour notre plus grand plaisir, elle a repris sa plume et nous narre la saison de deux délicieuses débutantes.
SHP-2 acts via ROCK to regulate the cardiac actin cytoskeleton
Creators: name: Paden, Erika
name: Tandon, Panna
name: Taylor, Joan M.
name: Duddy, Jennifer
name: Conlon, Frank L.
name: Langdon, Yvette
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Noonan syndrome is one of the most common causes of human congenital heart disease and is frequently associated with missense mutations in the protein phosphatase SHP-2. Interestingly, patients with acute myelogenous leukemia (AML), acute lymphoblastic leukemia (ALL), juvenile myelomonocytic leukemia (JMML) and LEOPARD syndrome frequently carry a second, somatically introduced subset of missense mutations in SHP-2. To determine the cellular and molecular mechanisms by which SHP-2 regulates heart development and, thus, understand how Noonan-associated mutations affect cardiogenesis, we introduced SHP-2 encoding the most prevalent Noonan syndrome and JMML mutations into Xenopus embryos. Resulting embryos show a direct relationship between a Noonan SHP-2 mutation and its ability to cause cardiac defects in Xenopus; embryos expressing Noonan SHP-2 mutations exhibit morphologically abnormal hearts, whereas those expressing an SHP-2 JMML-associated mutation do not. Our studies indicate that the cardiac defects associated with the introduction of the Noonan-associated SHP-2 mutations are coupled with a delay or arrest of the cardiac cell cycle in M-phase and a failure of cardiomyocyte progenitors to incorporate into the developing heart. We show that these defects are a result of an underlying malformation in the formation and polarity of cardiac actin fibers and F-actin deposition. We show that these defects can be rescued in culture and in embryos through the inhibition of the Rho-associated, coiled-coil-containing protein kinase 1 (ROCK), thus demonstrating a direct relationship between SHP-2N308D and ROCK activation in the developing heart.
Figure S11 from Comparative genomic analysis of the ‘psuedofungus’ Hyphochytrium catenoides.
Creators: name: Leonard, Guy
name: Labarre, Aurélie
name: Milner, David S.
name: Monier, Adam
name: Soanes, Darren
name: Wideman, Jeremy G.
name: Maguire, Finlay
name: Stevens, Sam
name: Sain, Divya
name: Grau-Bove, Xavier
name: Arnau Sebe-Pedros
name: Stajich, Jason E.
name: Paszkiewicz, Konrad
name: Brown, Matthew W.
name: Hall, Neil
name: Wickstead, Bill
name: Richards, Thomas A.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 60408 Genomics
subject: FOS: Biological sciences

description: Eukaryotic microbes have three primary mechanisms for obtaining nutrients and energy: phagotrophy, photosynthesis and osmotrophy. Traits associated with the latter two functions arose independently multiple times in the eukaryotes. Fungi successfully coupled osmotrophy with filamentous growth, similar traits are also manifested in the Pseudofungi (oomycetes and hyphochytriomycetes). Both the Fungi and the Pseudofungi encompass a diversity of plant and animal parasites. Genome-sequencing efforts have focused on host-associated microbes (mutualistic symbionts or parasites), providing limited comparisons with free-living relatives. Here we report the first draft genome sequence of a hyphochytriomycete ‘pseudofungus’; Hyphochytrium catenoides. Using phylogenomic approaches, we identify genes of recent viral ancestry, with related viral derived genes also present on the genomes of oomycetes, suggesting a complex history of viral coevolution and integration across the Pseudofungi. H. catenoides has a complex life cycle involving diverse filamentous structures and a flagellated zoospore with a single anterior-tinselate flagellum. We use genome comparisons, drug sensitivity analysis and high-throughput culture arrays to investigate the ancestry of oomycete/pseudofungal characteristics and metabolic traits, demonstrating that many of the genetic features associated with pathogenic traits evolved specifically within the oomycete radiation. Comparative genomics also identified differences in the repertoire of genes associated with filamentous growth between the Fungi and the Pseudofungi, including differences in vesicle trafficking systems, cell-wall synthesis pathways and motor protein repertoire, demonstrating that unique cellular systems underpinned the convergent evolution of filamentous osmotrophic growth in these two eukaryotic groups.
The F-BAR domains from srGAP1, srGAP2 and srGAP3 regulate membrane deformation differently
Creators: name: Ghukasyan, Vladimir
name: Coutinho-Budd, Jaeda
name: Polleux, Franck
name: Zylka, Mark J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Coordination of membrane deformation and cytoskeletal dynamics lies at the heart of many biological processes critical for cell polarity, motility and morphogenesis. We have recently shown that Slit-Robo GTPase-activating protein 2 (srGAP2) regulates neuronal morphogenesis through the ability of its F-BAR domain to regulate membrane deformation and induce filopodia formation. Here, we demonstrate that the F-BAR domains of two closely related family members, srGAP1 and srGAP3 [designated F-BAR(1) and F-BAR(3), respectively] display significantly different membrane deformation properties in non-neuronal COS7 cells and in cortical neurons. F-BAR(3) induces filopodia in both cell types, though less potently than F-BAR(2), whereas F-BAR(1) prevents filopodia formation in cortical neurons and reduces plasma membrane dynamics. These three F-BAR domains can heterodimerize, and they act synergistically towards filopodia induction in COS7 cells. As measured by fluorescence recovery after photobleaching, F-BAR(2) displays faster molecular dynamics than F-BAR(3) and F-BAR(1) at the plasma membrane, which correlates well with its increased potency to induce filopodia. We also show that the molecular dynamic properties of F-BAR(2) at the membrane are partially dependent on F-Actin. Interestingly, acute phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] depletion in cells does not interfere with plasma membrane localization of F-BAR(2), which is compatible with our result showing that F-BAR(2) binds to a broad range of negatively-charged phospholipids present at the plasma membrane, including phosphatidylserine (PtdSer). Overall, our results provide novel insights into the functional diversity of the membrane deformation properties of this subclass of F-BAR-domains required for cell morphogenesis.
The role of bars in quenching star formation from z = 3 to the present epoch. Halpha3: an Halpha imaging survey of HI selected galaxies from ALFALFA, VI
Creators: name: Gavazzi, G.
name: Consolandi, G.
name: Dotti, M.
name: Fanali, R.
name: Fossati, M.
name: Fumagalli, M.
name: Viscardi, E.
name: Savorgnan, G.
name: Boselli, A.
name: Gutiérrez, L.
name: Toledo, H. Hernández
name: Giovanelli, R.
name: Haynes, M. P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: A growing body of evidence indicates that the star formation rate per unit stellar mass (sSFR) decreases with increasing mass in normal "main-sequence" star forming galaxies. Many processes have been advocated as responsible for such a trend (also known as mass quenching), e.g., feedback from active galactic nuclei (AGNs), and the formation of classical bulges. We determine a refined star formation versus stellar mass relation in the local Universe. To this aim we use the Halpha narrow-band imaging follow-up survey (Halpha3) of field galaxies selected from the HI Arecibo Legacy Fast ALFA Survey (ALFALFA) in the Coma and Local superclusters. By complementing this local determination with high-redshift measurements from the literature, we reconstruct the star formation history of main-sequence galaxies as a function of stellar mass from the present epoch up to z=3. In agreement with previous studies, our analysis shows that quenching mechanisms occur above a threshold stellar mass M_knee that evolves with redshift as propto (1+z)^{2}. Moreover, visual morphological classification of individual objects in our local sample reveals a sharp increase in the fraction of visually-classified strong bars with mass, hinting that strong bars may contribute to the observed downturn in the sSFR above M_knee. We test this hypothesis using a simple but physically-motivated numerical model for bar formation, finding that strong bars can rapidly quench star formation in the central few kpc of field galaxies. We conclude that strong bars contribute significantly to the red colors observed in the inner parts of massive galaxies, although additional mechanisms are likely required to quench the star formation in the outer regions of massive spiral galaxies. Intriguingly, when we extrapolate our model to higher redshifts, we successfully recover the observed redshift evolution for M_knee.
description: accepted for publication in Astronomy & Astrophysics
The KMN protein network - chief conductors of the kinetochore orchestra
Creators: name: Salmon, E. D.
name: Varma, Dileep
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Successful completion of mitosis requires that sister kinetochores become attached end-on to the plus ends of spindle microtubules (MTs) in prometaphase, thereby forming kinetochore microtubules (kMTs) that tether one sister to one spindle pole and the other sister to the opposite pole. Sites for kMT attachment provide at least four key functions: robust and dynamic kMT anchorage; force generation that can be coupled to kMT plus-end dynamics; correction of errors in kMT attachment; and control of the spindle assembly checkpoint (SAC). The SAC typically delays anaphase until chromosomes achieve metaphase alignment with each sister kinetochore acquiring a full complement of kMTs. Although it has been known for over 30 years that MT motor proteins reside at kinetochores, a highly conserved network of protein complexes, called the KMN network, has emerged in recent years as the primary interface between the kinetochore and kMTs. This Commentary will summarize recent advances in our understanding of the role of the KMN network for the key kinetochore functions, with a focus on human cells.
Figure S14 from Comparative genomic analysis of the ‘psuedofungus’ Hyphochytrium catenoides
Creators: name: Leonard, Guy
name: Labarre, Aurélie
name: Milner, David S.
name: Monier, Adam
name: Soanes, Darren
name: Wideman, Jeremy G.
name: Maguire, Finlay
name: Stevens, Sam
name: Sain, Divya
name: Grau-Bove, Xavier
name: Arnau Sebe-Pedros
name: Stajich, Jason E.
name: Paszkiewicz, Konrad
name: Brown, Matthew W.
name: Hall, Neil
name: Wickstead, Bill
name: Richards, Thomas A.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 60408 Genomics
subject: FOS: Biological sciences

description: Eukaryotic microbes have three primary mechanisms for obtaining nutrients and energy: phagotrophy, photosynthesis and osmotrophy. Traits associated with the latter two functions arose independently multiple times in the eukaryotes. Fungi successfully coupled osmotrophy with filamentous growth, similar traits are also manifested in the Pseudofungi (oomycetes and hyphochytriomycetes). Both the Fungi and the Pseudofungi encompass a diversity of plant and animal parasites. Genome-sequencing efforts have focused on host-associated microbes (mutualistic symbionts or parasites), providing limited comparisons with free-living relatives. Here we report the first draft genome sequence of a hyphochytriomycete ‘pseudofungus’; Hyphochytrium catenoides. Using phylogenomic approaches, we identify genes of recent viral ancestry, with related viral derived genes also present on the genomes of oomycetes, suggesting a complex history of viral coevolution and integration across the Pseudofungi. H. catenoides has a complex life cycle involving diverse filamentous structures and a flagellated zoospore with a single anterior-tinselate flagellum. We use genome comparisons, drug sensitivity analysis and high-throughput culture arrays to investigate the ancestry of oomycete/pseudofungal characteristics and metabolic traits, demonstrating that many of the genetic features associated with pathogenic traits evolved specifically within the oomycete radiation. Comparative genomics also identified differences in the repertoire of genes associated with filamentous growth between the Fungi and the Pseudofungi, including differences in vesicle trafficking systems, cell-wall synthesis pathways and motor protein repertoire, demonstrating that unique cellular systems underpinned the convergent evolution of filamentous osmotrophic growth in these two eukaryotic groups.
Download PDF La France avant la France 481-888
Creators: name: Thomas
Publisher: name: Zenodo
Year: 2024

description: La France avant la France 481-888 pan Geneviève Bührer-Thierry, Charles Mériaux

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La France avant la France 481-888

Geneviève Bührer-Thierry, Charles Mériaux

Nb. de pages: 687

Format: Pdf, ePub, MOBI, FB2

ISBN: 9782701191881

Editeur: Belin

Date de parution: 2014

 

 

 

Téléchargements de livres gratuits pour tablettes La France avant la France 481-888 in French par Geneviève Bührer-Thierry, Charles Mériaux

 

Overview

L'histoire a longtemps juxtaposé des images simples pour définir les quatre siècles écoulés de 481 à 888 : aux Mérovingiens incultes et incapables, succédaient des Carolingiens glorieux et conquérants. Les recherches des dernières décennies, fondées sur une réévaluation des sources écrites et sur les progrès de l'archéologie, ont libéré cette période du carcan des idées reçues. Ce livre, en forme de bilan, dresse des perspectives neuves. Il montre notamment que les rois mérovingiens furent les derniers continuateurs de l'Antiquité et que si les premiers Carolingiens rassemblèrent sous leur autorité presque toute l'Europe occidentale, l'Empire s'avéra une réalité fragile et diverse. Ainsi, les auteurs ramènent-ils les faits aux réalités de l'époque, en rejetant les anachronismes et les outrances, et en appuyant leur exposé sur des textes et des cartes comme sur une iconographie abondante. Cette histoire renouvelée possède un attrait majeur : au-delà des représentations traditionnelles, elle s'efforce d'atteindre le réel.
(2807) Thomas Hopkinson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Antagonism and synergy between extracellular BMP modulators Tsg and BMPER balance blood vessel formation
Creators: name: Heinke, Jennifer
name: Patterson, Cam
name: Helbing, Thomas
name: Moser, Martin
name: Juschkat, Maria
name: Charlet, Anne
name: Mnich, Leonie
name: Bode, Christoph
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Growth and regeneration of blood vessels are crucial processes during embryonic development and in adult disease. Members of the bone morphogenetic protein (BMP) family are growth factors known to play a key role in vascular development. The BMP pathway is controlled by extracellular BMP modulators such as BMP endothelial cell precursor derived regulator (BMPER), which we reported previously acts proangiogenically on endothelial cells in a concentration-dependent manner. Here, we explore the function of other BMP modulators, especially Tsg, on endothelial cell behaviour and compare them to BMPER. In Matrigel assays, BMP modulators chordin and noggin had no stimulatory effect; however, gremlin and Tsg enhanced human umbilical vein endothelial cell (HUVEC) sprouting. As the activation dynamics of Tsg were similar to those of BMPER, we further investigated the proangiogenic effect of Tsg on endothelial cells. Tsg enhanced endothelial cell ingrowth in the mouse Matrigel plug assay as well as HUVEC sprouting, migration and proliferation
The electronic spectra of protonated PANH molecules
Creators: name: Noble, J. A.
name: Dedonder, C.
name: Jouvet, C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Atomic and Molecular Clusters (physics.atm-clus)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Aims. This study was designed to examine the viability of protonated nitrogen-substituted polycyclic aromatic hydrocarbons (H+PANHs) as candidates for the carriers of the diffuse interstellar bands (DIBs). Methods. We obtained the electronic spectra of two protonated PANH cations, protonated acridine and phenanthridine, using parent ion photo-fragment spectroscopy and generated theoretical electronic spectra using ab initio calculations. Results. We show that the spectra of the two species studied here do not correspond to known DIBs. However, based on the general properties derived from the spectra of these small protonated nitrogen-substituted PAHs, we propose that larger H+PANH cations represent good candidates for DIB carriers due to the expected positions of their electronic transitions in the UV-visible and their narrow spectral bands.
description: 7 pages, 2 figures, accepted for publication in A&A
(2808) Lucy [Hopkinson]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The schmidt 67/92 robotic telescope - roboschmidt user manual
Creators: name: TOMASELLA, Lina
name: CAPPELLARO, Enrico
name: BENETTI, Stefano
Publisher: name: O.A. Padova
Year: 2023

description: The 67/91 Schmidt telescope is the largest instrument of this type in Italy. It was officially commissioned in 1966; in 1991 the telescope was moved to mount Ekar, near the Copernico 1.82m telescope, in order to take advantage of the higher altitude and lower light pollution. In 2017 the telescope has been considerably refurbished (new CCD camera, new filters, autoguider) and remotely controlled. Starting from May, 2020 updates of both hardware and software allowed the implementation of the fully robotic operational mode . The observing blocks (OB) are submitted at any time by the PIs of the proposals or their collaborators. The Robotic System has a rapid-response capability that allows it to interrupt regular observations in order to observe transient phenomena with high priority.
Additional file 1 of Effect of a self-help group intervention using Teaching Recovery Techniques to improve mental health among Syrian refugees in Norway: a randomized controlled trial
Creators: name: Hasha, Wegdan
name: Igland, Jannicke
name: Fadnes, Lars T.
name: Kumar, Bernadette N.
name: Heltne, Unni M.
name: Diaz, Esperanza
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Table A1. Number of participants who attended TRT sessions in each intervention and control groups by gender. Table A2. Group comparisons on characteristics of follow-up and dropped out. Table A3. Change in outcomes from first to last session and six weeks after last session for intervention and control groups combined (n=76) using linear mixed models.
(2809) William Mann
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
APC2 and Axin promote mitotic fidelity by facilitating centrosome separation and cytoskeletal regulation
Creators: name: Poulton, John S.
name: Mu, Frank W.
name: Peifer, Mark
name: Roberts, David M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: To ensure the accurate transmission of genetic material, chromosome segregation must occur with extremely high fidelity. Segregation errors lead to chromosomal instability (CIN), with deleterious consequences. Mutations in the tumor suppressor adenomatous polyposis coli (APC) initiate most colon cancers and have also been suggested to promote disease progression through increased CIN, but the mechanistic role of APC in preventing CIN remains controversial. Using fly embryos as a model, we investigated the role of APC proteins in CIN. Our findings suggest that APC2 loss leads to increased rates of chromosome segregation error. This occurs through a cascade of events beginning with incomplete centrosome separation leading to failure to inhibit formation of ectopic cleavage furrows, which result in mitotic defects and DNA damage. We test several hypotheses related to the mechanism of action of APC2, revealing that APC2 functions at the embryonic cortex with several protein partners, including Axin, to promote mitotic fidelity. Our in vivo data demonstrate that APC2 protects genome stability by modulating mitotic fidelity through regulation of the cytoskeleton.
Modeling water uptake by a root system growing in a fixed soil volume
Creators: name: Albrieu, J. L. Blengino
name: Reginato, J. C.
name: Tarzia, D. A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Computational Physics (physics.comp-ph)
subject: Tissues and Organs (q-bio.TO)
subject: FOS: Physical sciences
subject: FOS: Biological sciences
subject: 35Q92, 35R37, 65M60, 76505

description: The water uptake by roots of plants is examined for an ideal situation, with an approximation that resembles plants growing in pots, meaning that the total soil volume is fixed. We propose a coupled water uptake-root growth model. A one-dimensional model for water flux and water uptake by a root system growing uniformly distributed in the soil is presented, and the Van Genuchten model for the transport of water in soil is used. The governing equations are represented by a moving boundary model for which the root length, as a function of time, is prescribed. The solution of the model is obtained by front-fixing and finite element methods. Model predictions for water uptake by a same plant growing in loam, silt and clay soils are obtained and compared. A sensitivity analysis to determine relative effects on water uptake when system parameters are changed is also presented and shows that the model and numerical method proposed are more sensitive to the root growth rate than to the rest of the parameters. This sensitivity decreases along time, reaching its maximum at thirty days. A comparison of this model with a fixed boundary model with and without root growth is also made. The results show qualitative differences from the beginning of the simulations, and quantitative differences after ten days of simulations.
description: To Appear in Applied mathematical modelling 23 pages, 10 figures