cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Mechanics of hamstring function in sprinting
Creators: name: Ede, Carlie
Publisher: name: Loughborough University
Year: 2023
Subjects: Sports science and exercise not elsewhere classified

description: Hamstring strain injury is commonly reported as one of the leading causes of injury in many competitive sports, resulting in significant performance, health and financial implications. Despite a growing body of research, little change has been observed in the prevalence of hamstring strain injury, suggesting the current areas of knowledge may be incomplete. The purpose of this study was to develop a suitable musculoskeletal model to examine hamstring function during sprinting and its relationship with hamstring strain Injury. Experimental data was collected on one male participant running at submaximal and maximal speeds (overground and treadmill). The open-source software, OpenSim, was used to construct, evaluate, and optimise a 3-dimensional musculoskeletal model suitable for sprint running. To successfully simulate sprinting, adjustments were made to a generic model including ranges of motion, anthropometrics, and muscle parameters. The final model was shown to produce realistic estimates of movement and muscle performance. The choice of optimisation method was shown to be important, with direct collocation achieving a dynamically consistent and viable solution, presenting a feasible framework for the investigation of ballistic movements. Hamstring function and joint moments were shown to significantly increase with running speed, supporting the suggestion that hamstring injury risk significantly increases with running speed. Other findings emphasised that the terminal swing is a critical period when the hamstring is at most risk of injury. Investigating multiple strides revealed high variability in hamstring muscle function, showing large changes in the relative load between the hamstring muscles. Previous sprinting research is often limited to a single representative stride, providing a narrowed view on hamstring muscle function. Future research may need to include multiple running strides to better understand the relationship between muscle function and hamstring strain injury. Finally, the effects of altering muscle strength and fibre length on hamstring function were quantified. Findings reveals that adjusting biceps femoris long head fibre length resulted in minimal changes to simulation performance and hamstring function. Reductions in hamstring or gluteal strength, or increases in quadriceps strength, resulted in poorer simulation performance and large changes to hamstring muscle function. Reduced simulation performance was characterised by large changes in the pelvic orientation, supporting the suggestion of pelvic instability as a risk factor for hamstring strain injury.
title: IoT and Edge Computing Technologies for Vertical Farming from Seed to Harvesting
titleType: AlternativeTitle
Creators: name: Jandl, Adrian
Publisher: name: TU Wien
Year: 2021
Subjects: subject: Vertikales farmen
subject: Edge Computing
subject: Internet of Things
subject: Sensoren
subject: Deployment Szenarien
subject: Benchmarks
subject: vertical farming
subject: edge computing
subject: internet of things
subject: sensors
subject: deployment scenarios
subject: benchmark experiments

description: With the ever growing global population, a key challenge of the future will be providing enough food for people. One proposed solution to this is vertical farming, which is the practice of growing crops vertically, above each other in order to increase total crop yield for a given space. Supported by IoT technologies, such as sensors and artificial lighting, it allows farmers to utilize spaces that previously did not provide suitable growing conditions for crops, such as underground car parks, or abandoned underground tunnels. By utilizing developments in IoT technologies, and mechanisms for efficient management of large volumes of IoT-generated data, such as stream processing, it is now possible to measure and analyse the vast amount of parameters that influence plant growth, such as humidity or temperature. This makes it possible to facilitate continuous monitoring and decision making at runtime towards a fully autonomic management of vertical farming processes. Importantly, these technologies can provide support for long-term storage and analysis of such data, in order to create new domain knowledge, such as by developing databases that contain optimal growth parameters for a majority of edible plants.In this thesis we lay the groundwork for such mechanisms. We analyse the software design requirements for a system that can gather such information, as well as analyse various network topologies and deployment strategies for it. In addition, we show an implementation that already can be used to gather important data.Our software architecture lays a focus on extensibility and allows others to easily build upon it. Last, we perform extensive testbed experiments to evaluate the performance of our scheme and to demonstrate its feasibility to operate in diverse deployment scenarios and network architectures and topologies. Aiming to identify the performance limits of low-cost edge computing equipment, we deploy the components of our architecture on low-end single board computers and show them to be able to support monitoring workloads that correspond to thousands of sensing devices. We further explore experimentally the performance and design implications of using modern Low-Power Wide Area Networking technologies, and in particular LoRaWAN, to collect monitoring data from remote vertical farms with minimal network infrastructure requirements. We show that while deploying and managing a full private LPWAN over edge computing devices may have significant effects on the overall system's workload processing capacity, it is still possible to support large-scale vertical farm installations.
Studio practice : experiments in objectless and objectiveless artmaking
Creators: name: Desideri, Valentina
Publisher: name: University of British Columbia
Year: 2023

description: This exegesis reflects on a set of objectless and objectiveless art practices that compose my Studio Practice, which I propose as an approach to artmaking as study and to study as artmaking. In addition to reviewing the relevant theoretical concepts that inform my practice, I discuss four instances of my Studio Practice: the practice of Political Therapy , the collaborative practice of Poethical Readings with Denise Ferreira da Silva, an example of my approach to teaching as study and the performance practice Performance Studies. Political Therapy is a one-to-one artistic practice that addresses through touch a political problem brought up by the participant. Poethical Readings experiment with well-known and newly-designed reading tools – such as the Tarots, Fake Therapy, Reiki, Astrology, amongst others – to image ethical and political questions. My approach to teaching as study experiments with turning any invitation to teach as an occasion for study to self-organize. Finally, Performance Studies is a collaborative practice of performance-making that considers the specific ways in which performance plots attention as productive of knowledge. As an aesthetic praxis, Studio Practice experiments with ways of knowing and making that do not presuppose a knowing subject, an author, or a beholder but rather remain incomplete, in/as study. Indebted to black study, study is understood as a political practice of self-organization which experiments with modes of being together that enact a critical perspective on the modern Subject.
Hamburg Open Science: Forschungsdatenmanagement: Abschluss Prototypentwicklung
Creators: name: Rajski, Beate
name: Wörner, Kai
Publisher: name: Zenodo
Year: 2018
Subjects: research data repository
Hamburg

description: Zur Herbeiführung einer Entscheidung für ein FDM-System pro Institution in Hamburg Open Science werden bis Mitte November 2018 zwei Prototypen entwickelt und exemplarisch mit Testdaten befüllt:
 1. TUHH: auf Basis von DSpace CRIS (Open Source)
 2. UHH: auf Basis von Invenio/Zenodo (Open Source)
Machine learning enhanced resource allocation in wireless networks
Creators: name: Chen, Tianrui
Publisher: name: Loughborough University
Year: 2023
Subjects: Mechanical engineering not elsewhere classified
Electrical engineering not elsewhere classified
Manufacturing engineering not elsewhere classified

description: Resource allocation is a fundamental research topic in wireless communications. With the rapid development of wireless communication systems, the conventional optimization algorithms for resource allocation cannot meet improving requirements such as real-time execution, generalizability to larger networks, distributed implementation, and privacy. To mitigate the aforementioned challenges, this thesis focuses on developing machine learning (ML) methods to enhance resource allocation in wireless networks. Firstly, discrete optimization problems are considered. A graph neural network (GNN) based framework is proposed to solve such problems, and its effectiveness is verified by two case studies, namely link scheduling in device-to-device (D2D) wireless networks and joint channel and power allocation in D2D underlaid cellular networks. Secondly, the proposed GNN approach is extended to address a more complicated continuous optimization problem, i.e., D2D beamforming design. To reduce the learning complexity, the structure of the optimal beamforming is adopted to transfer the beamforming to primal power and dual variables. Therefore, the GNN learns these variables instead of the direct beamforming. Simulation results demonstrate that the proposed GNN approach achieves better sum rate than the state-of-the-art benchmarks, and reduces the execution time to millisecond-level which is favorable in the time-stringent applications. Besides, the GNN approach has great features desired in wireless communications including the generalizability to large networks without retraining and the robustness to corrupted input features. However, the implementation of the proposed GNN method is centralized. Consequently, a decentralized federated learning (FL) approach is proposed to address the D2D link scheduling problem, in which a shared model is distributedly trained by each client, hence the privacy of each client is guaranteed. This is the first work that utilizes FL to solve the D2D link scheduling problem in a distributed manner. Numerical results show that the proposed FL method achieves almost the same performance in terms of the accuracy and the sum rate as the centralized training.
title: Behavioural effects of pheromone-based control system, Exosex™ SPTab, on male Indianmeal moth, Plodia interpunctella
Creators: name: Huggett, N. J.
name: Storm, C. G.
name: Smith, M. J.
Publisher: name: Julius Kühn-Institut
Year: 2010
Subjects: subject: mating disruption
subject: Plodia interpunctella
subject: Exosex SPTab
subject: sex pheromone
subject: flight tunnel

description: Julius-Kühn-Archiv; 425; 119-124
A passion for the Republic
Creators: name: Premat, Christophe
Publisher: name: Stockholm University
Year: 2023
Subjects: classificationCode: 470299
subject: Cultural studies not elsewhere classified
classificationCode: 430399
subject: Historical studies not elsewhere classified

description: This is a presentation of a course given at Stockholm University ("Culture and politics in contemporary France", basic level) based on the publication of the book of Hazareesingh, (2015). How the French think: an affectionate portrait of an intellectual people. Basic Books, a member of the Perseus Books Group. The aim is to analyze the development of Republican ideas in contemporary France.
MPEC 2023-J153 : 2023 JN2
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 JN2

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Additional file 5 of RNF31 represses cell progression and immune evasion via YAP/PD-L1 suppression in triple negative breast Cancer
Creators: name: Yang, Huijie
name: Xue, Min
name: Su, Peng
name: Zhou, Yan
name: Li, Xin
name: Li, Zhongbo
name: Xia, Yan
name: Zhang, Chenmiao
name: Fu, Mingxi
name: Zheng, Xiuxia
name: Luo, Guosheng
name: Wei, Tian
name: Wang, Xinxing
name: Ding, Yinlu
name: Zhu, Jian
name: Zhuang, Ting
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 5 Supplementary Fig. 5 A and E Western blot detecting of PD-L1 and RNF31 expression in BT549 and HS578T cells with indicated treatment. B and F RT–qPCR results of PD-L1 mRNA level with indicated treatment in BT549 and HS578T cells. C-D and G-H The cell-membrane localized PD-L1 in BT549 and HS578T cells with indicated treatment were analyzed by Flow cytometry using PD-L1 antibody.
title: "Missbildung"
title: Interdiskriminierung in der extremen Rechten
titleType: Subtitle
Creators: name: Hechler, Andreas
Publisher: name: Mandelbaum Verlag
Year: 2019
Subjects: subject: Intersexualität
subject: Gewalt
subject: Männlichkeit
subject: Rechtsextremismus
subject: Rassismus
subject: Antisemitismus
subject: Antifaschismus
subject: Intersektionalität
subject: Antifeminismus
subject: Diskriminierung
subject: Antidiskriminierung
subject: 300 Sozialwissenschaften
subject: Intergeschlechtlichkeit
subject: Interdiskriminierung
subject: Interfeindlichkeit
subject: Endosexismus

description: In den folgenden Ausführungen geht es um die These, dass ein Wissen um lntergeschlechtlichkeit und die sie umgebenden Diskurse notwendig ist, um gegenwärtige rechte Diskursformationen rund um das Thema Geschlecht adäquat analysieren zu können. Aus intersektionaler Perspektive werden einerseits die interdiskriminierenden Effekte und Ressentimentstrukturen eines spezifisch rechten Diskurses um "Gender(ismus)" aufgezeigt, andererseits wird der Umgang mit Intergeschlechtlichkeit und die Diskriminierung intergeschlechtlicher Menschen durch rechte Akteur_innen dargestellt.
title: Study on volatile compounds in rice by HS-SPME and GC-MS
Creators: name: Lin, J.-Y.
name: Fan, W.
name: Gao, Y.-N.
name: Wu, S.-F.
name: Wang, S.-X.
Publisher: name: Julius Kühn-Institut
Year: 2010
Subjects: subject: headspace solid phase micro-extraction
subject: rice
subject: gas chromatographic and mass spectrum
subject: volatile substances

description: Julius-Kühn-Archiv; 425; 125-134
ניסוי קורס ניסויית קבוצה 3 - תופעת הגילנות
Creators: name: Golan, Mor Steinberg
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Psychology
subject: FOS: Psychology
subject: Social and Behavioral Sciences

description: זוהי הרשמה מראש למחקר שלנו במסגרת קורס פסיכולוגיה ניסויית.
MPEC 2023-J154 : 2023 JO2
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 JO2

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
title: External egg morphology of common stored-product pests from the families Anobiidae (Ptininae) and Dermestidae (Coleoptera)
Creators: name: Kučerová, Z.
name: Hromádková, J.
name: Stejskal, V.
Publisher: name: Julius Kühn-Institut
Year: 2010
Subjects: subject: egg morphology
subject: SEM micrographs
subject: stored-product pest identification

description: Julius-Kühn-Archiv; 425; 135-138
Additional file 1 of Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer’s disease: results from the DELCODE study
Creators: name: Brosseron, Frederic
name: Maass, Anne
name: Kleineidam, Luca
name: Ravichandran, Kishore Aravind
name: Kolbe, Carl-Christian
name: Wolfsgruber, Steffen
name: Santarelli, Francesco
name: Häsler, Lisa M.
name: McManus, Róisín
name: Ising, Christina
name: Röske, Sandra
name: Peters, Oliver
name: Cosma, Nicoleta-Carmen
name: Schneider, Luisa-Sophie
name: Wang, Xiao
name: Priller, Josef
name: Spruth, Eike J.
name: Altenstein, Slawek
name: Schneider, Anja
name: Fliessbach, Klaus
name: Wiltfang, Jens
name: Schott, Björn H.
name: Buerger, Katharina
name: Janowitz, Daniel
name: Dichgans, Martin
name: Perneczky, Robert
name: Rauchmann, Boris-Stephan
name: Teipel, Stefan
name: Kilimann, Ingo
name: Görß, Doreen
name: Laske, Christoph
name: Munk, Matthias H.
name: Düzel, Emrah
name: Yakupow, Renat
name: Dobisch, Laura
name: Metzger, Coraline D.
name: Glanz, Wenzel
name: Ewers, Michael
name: Dechent, Peter
name: Haynes, John Dylan
name: Scheffler, Klaus
name: Roy, Nina
name: Rostamzadeh, Ayda
name: Spottke, Annika
name: Ramirez, Alfredo
name: Mengel, David
name: Synofzik, Matthis
name: Jucker, Mathias
name: Latz, Eicke
name: Jessen, Frank
name: Wagner, Michael
name: Heneka, Michael T.
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Neuroscience
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health
subject: Hematology

description: Additional file 1.
Feminist conversation analysis: Examining violence against women
Creators: name: Tennent, Emma
name: Weatherall, Ann
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2022
Subjects: Uncategorized

description: Feminist conversation analysis is a powerful methodology for research on language, gender, and sexuality. Although this research approach has been controversial, feminist conversation analysis is a productive approach to examine how issues of gender, power, and identity are consequential in everyday social interactions. The chapter reviews feminist conversation analytic research that has examined oppression in everyday life, the organisation of the gendered social-moral order, and interventions for social change. We illustrate the methodological approach with a discussion of our research project on violence against women. Analysis of calls to a victim support service demonstrates how women disclose violence and negotiate the meanings of victimhood while seeking help. Our findings show that callers described themselves and their problems in ways that invoked common-sense cultural knowledge about gendered violence. Analysing the turn-by-turn unfolding of social interaction provides insight on longstanding feminist questions, such as the difficulties of disclosing violence, women’s experiences with criminal justice institutions, and the practicalities of seeking support. Focusing on what people do and say as they seek help can be used to improve the delivery of service, thus making a practice difference for people in need. Grounded analysis of everyday interactions thus offer remarkable potential for feminist aims.
Map #422, Site 5MT10647, Pithouse 205-226, Nonstructure 216 (Surface 1), and Nonstructure 225
Creators: name: DeVos, Jim
Year: 2018
Subjects: subject: Southwestern Colorado
valueUri: https://core.tdar.org/browse/geographic-keyword/2810/southwestern-colorado
subject: Southwestern US
valueUri: https://core.tdar.org/browse/geographic-keyword/84604/southwestern-us
subject: Basketmaker III
valueUri: https://core.tdar.org/browse/temporal-keyword/78/basketmaker-iii
subject: Pueblo I
valueUri: https://core.tdar.org/browse/temporal-keyword/54/pueblo-i
subject: Pueblo II
valueUri: https://core.tdar.org/browse/temporal-keyword/55/pueblo-ii
subject: 5MT10647
valueUri: https://core.tdar.org/browse/site-name/118013/5mt10647
subject: Dillard Site
valueUri: https://core.tdar.org/browse/site-name/118012/dillard-site

description: Site 5MT10647, Pithouse 205-226, Nonstructure 216 (Surface 1), and Nonstructure 225
UNDERSTANDING THE CATALYTIC MECHANISMS OF UBIQUITIN-E3 LIGASES
Creators: name: VALENTINI, ELEONORA
Publisher: name: Universit� degli Studi di Milano
Year: 2016

description: E3 ubiquitin ligases are key regulatory enzymes of the ubiquitination pathway as they are responsible for substrate specificity. This thesis aimed at deciphering the molecular mechanisms through which two different E3 ligases, Nedd4 and Rabex-5, exert their activity. Nedd4 is the prototype for HECT-E3 ligase while Rabex-5, containing an A20 zinc finger domain (ZnF_A20) instead of a canonical RING, could be defined as an atypical RING-E3 ligase. In the case of Nedd4, we provided the first crystal structure of the catalytic intermediate of HECTNedd4~Ub in complex with Ub non-covalently bound to the UBD present in the N-lobe of HECTNedd4. Our structure represents the next step of the transfer of UbD from the catalytic cysteine of E2 to the one of E3 in which the UbD C-terminal tail is in an extended conformation primed for catalysis. Our data strongly supports the sequential addition model proposed for HECT proteins. Within this study we also clarified some aspects of Rabex-5 as E3 ligase. By yeast-two-hybrid, GST-pull-down assays and ITC analysis, we identified specific E2 partners, Ube2D and Ube2E families, that bind Rabex-5 only when in their active Ub-loaded state. Performing in vitro auto-ubiquitination assay and disulfide stability assay we confirmed that ZnF_A20 is the minimal domain responsible for the catalytic activity. To obtain the structure of the Rabex-51-74:E2-Ub complex, we tested, unfortunately without success, crystallization trials and SAXS analysis with various samples. We also analyzed Rabex-5 catalytic activity towards on H-Ras, which is the unique substrate of Rabex-5 so far identified, and we disproved that H-Ras is a Rabex-5 substrate. To identify candidate substrates we profiled 20.000 human proteins using a microarray-based ubiquitination screening. A list of 67 proteins represent the most statistically stringent and conservative estimate for Rabex-5 substrates that we are going to validate in the nearest future, starting from the ones involved in the endocytic pathway. ?
Scellnetor_standalone_scripts_data
Creators: name: Grønning, Alexander G. B.
Publisher: name: Zenodo
Year: 2021
Subjects: Single-cell, clustering, trajectory, pseudotime

description: Dear reader, This folder contains: Additional scripts used for pre-processing and analysis (in the "additional_scripts.zip" file) "old" Scellnetor output files, which can readily be used to reproduce results presented in the article (see "Kanev_et_al.zip", "Paul_et_al.zip", "Paul_et_al_sorting_n_count_all.zip" and "Paul_et_al_sorting_pseudotime.zip"). The standalone version of Scellnetor, which consists of three ZIP files: "composeexample.zip" "static.zip" "Docker_n_Django_files.zip" These are the steps you need to follow to make the program work: Create a folder called "Scellnetor" Unzip "Docker_n_Django_files.zip" and move all its contents to the folder "Scellnetor" Move "composeexample.zip"" and "static.zip" to the folder Scellnetor and unzip them This creates two folders called "composeexample" and "static" Go to the "Scellnetor" folder sudo docker-compose build (takes ~1 hour) sudo docker-compose up go to: http://0.0.0.0:8000/ It is also possible to download the standalone version of Scellnetor from https://gitlab.com/AlexTheKing/scellnetor_docker_public (easier). You can also use the GitLab repository to see how the folders are supposed to be structured and get additional help. Enjoy.
Additional file 3 of RNF31 represses cell progression and immune evasion via YAP/PD-L1 suppression in triple negative breast Cancer
Creators: name: Yang, Huijie
name: Xue, Min
name: Su, Peng
name: Zhou, Yan
name: Li, Xin
name: Li, Zhongbo
name: Xia, Yan
name: Zhang, Chenmiao
name: Fu, Mingxi
name: Zheng, Xiuxia
name: Luo, Guosheng
name: Wei, Tian
name: Wang, Xinxing
name: Ding, Yinlu
name: Zhu, Jian
name: Zhuang, Ting
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 3 Supplementary Fig. 3 A Western blot detecting of YAP expression in MDAMB231 cell exposed to indicated Verteporfin concentration for 12 h. B-C and J-K Transwell assay (left panel) of MDAMB231 cells. Right panel shows quantification of transwell assay results. Scale bar 100 μm. D-E and L-M FACS analysis (left panel) was performed on the MDAMB231 cell to detect the proportion of apoptotic cells. The cells were incubated with PI and Annexin V. Right panel shows quantification of apoptosis proportion. F-G and H-I Representative images (left panel) of EdU assays in MDAMB231 cell transfected with indicated treatment. EdU-positive cells, red; cell nuclei, blue. Right panel shows quantification of Edu results. Scale bar 100 μm.
Virtual screening of natural compounds as selective inhibitors of polo-like kinase-1 at C-terminal polo box and N-terminal catalytic domain
Creators: name: Olawale, Femi
name: Iwaloye, Opeyemi
name: Elekofehinti, Olusola Olalekan
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: The over-expression of Polo-like kinase-1 (PLK1) is associated with cancer prognosis due to its pivotal role in cell proliferation. The N-terminal catalytic domain (NCD) and C-terminal polo box domain (PBD) of PLK1 are critical for the activity of the protein. Drugs that inhibit PLK1 by targeting these domains are on clinical trials, but so far, none has been approved by FDA. Thus, this study targets the two domains of PLK1 to identify compounds with inhibitory potential. Four validated e-pharmacophore models from NCD (PDB ID: 2OU7 and 4J52) and PBD (PDB ID: 5NEI and 5NN2) were used to screen over 26,000 natural compounds from NPASS database. Hits were identified after the well-fitted compounds were subjected to molecular docking study and ADME prediction. The pIC50 and electronic behaviour of the identified hits selectively targeting NCD and PBD of PLK1 were predicted via an externally validated QSAR model and quantum mechanics. The results showed that CAA180504, CAA197326, CAA74619, CAA328856 modulating PLK1 at NCD, and CBB130581, CBB230713, CBB206123, CBB12656 and CBB267117 modulating PLK1 at PBD had better molecular docking scores, pharmacokinetics and drug-like properties than NCD (volasertib) and PBD (purpurogallin) reference inhibitors. The compounds all had satisfactory inhibitory (pIC50) values which range from 6.187 to 7.157. The electronic behaviours of understudied compounds using HOMO/LUMO and global descriptive parameters revealed the atomic portion of the compounds prone to donating and accepting electrons. In conclusion, the hit compounds identified from the library of natural compounds are worthy of further experimental validation. Communicated by Ramaswamy H. Sarma
Additional file 4 of RNF31 represses cell progression and immune evasion via YAP/PD-L1 suppression in triple negative breast Cancer
Creators: name: Yang, Huijie
name: Xue, Min
name: Su, Peng
name: Zhou, Yan
name: Li, Xin
name: Li, Zhongbo
name: Xia, Yan
name: Zhang, Chenmiao
name: Fu, Mingxi
name: Zheng, Xiuxia
name: Luo, Guosheng
name: Wei, Tian
name: Wang, Xinxing
name: Ding, Yinlu
name: Zhu, Jian
name: Zhuang, Ting
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 4 Supplementary Fig. 4 A-B Western blot detecting of YAP and RNF31 protein localized in cytoplasm and nucleus in the MDAMB231 cell with indicated treatment. Subcellular protein fractionation kit was used for cytoplasm and nucleus separation. Tubulin and Histone3 were engineered to cytoplasm and nucleus controls. Nucleus/Cytoplasm ratio of YAP protein (B). C Representative immunoblots to show the interaction between RNF31 with YAP or TAZ by immunoprecipitation (IP) with RNF31 antibody.
Finding the functional consequences of genetic risk loci on gene expression and DNA methylation by integrating contextual information
Creators: name: Casazza, William
Publisher: name: University of British Columbia
Year: 2023

description: The majority of genetic loci that influence complex traits are non-coding. Roughly half of these loci affect gene expression in one or more tissues, despite making up less than 10% of common genetic variants. However, it is increasingly unlikely that genetic effects on gene expression will be sufficient to assign a function to all non-coding risk loci. This thesis splits the problem of assigning new functions to complex trait loci into two steps. First, I aim to increase the number of non-coding loci with a known function without requiring new molecular datasets. In my thesis, I explore context-dependent genetic regulation of molecular traits, where the context that affects this process is either inferred from data or a common phenotypic measure like sex. I then advocate for associating genetic variation with molecular data other than gene expression, primarily on DNA methylation. Second, I outline how to tie these novel molecular functions to genetic risk for complex traits. Importantly, this requires methods and workflows that summarize genetic effects at individual loci across interpretable functional units (genes) and genome-wide genetic risk for complex traits. In my scholarship chapters, I first show that environments inferred from global gene expression can correlate with various phenotypic and environmental variables. These inferred contexts are replicated across samples and can subsequently be used to identify novel context-specific genetic regulation of gene expression. I then show that novel context-specific genetic regulation can be approached in DNA methylation using sex, measured in virtually all genetic and molecular datasets. My later chapters demonstrate how to summarize genetic effects to learn which traits are particularly relevant to these novel regulatory relationships. I start with effects and individual loci and then explore methods to interpret the gene-level influence of genetic effects on DNA methylation. Then I demonstrate how cumulative, genome-wide risk for complex traits can provide new insight into the biological functions underlying complex traits beyond the effects I observe at individual loci. Overall this thesis shows that we require various approaches to discover disease-relevant molecular functions of non-coding genetic loci.
title: Astronomical calibration of the Early Jurassic Sinemurian Stage based on cyclostratigraphic studies of downhole logging data of the Prees-2 borehole, England (ICDP JET Project)
Creators: name: Leu, Katharina
name: Zeeden, Christian
name: Ulfers, Arne
name: Ruhl, Micha
name: Hesselbo, Stephen Peter
name: Wonik, Thomas
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
In late 2020, an approximately 650 m long core was drilled at Prees within the Cheshire Basin, England, as part of the ICDP project JET (Integrated Understanding of the Early Jurassic Earth System and Timescale). The main objective of this project is to obtain a complete and continuous sedimentary archive of the Early Jurassic. The Early Jurassic (~200-175 million years) was a period of extreme environmental changes, which will serve as an analogue for present and future environmental change. The project aims to provide a reference record for an integrated stratigraphy (bio-, cyclo-, chemo- and magnetostratigraphy) of this period.

Analysis of geophysical borehole logs will allow the description of sedimentary cycles related to orbital parameters and paleoclimatic history if depositional environment and sedimentation rate permits. Here, downhole logging data from the Prees-2 borehole are used to construct a floating astronomical timescale for the Sinemurian stage, contributing to an integrated timescale for the Early Jurassic. Cyclostratigraphic methods, including a statistical and a visual approach, lead to preliminary durations for the Sinemurian stage of ~6.2 and 6.8 million years, respectively.
Moving Towards a General Metadata Extraction Solution for Research Data with State-of-the-Art Methods
Creators: name: Heinrichs, Benedikt Paul Anton
name: Politze, Marius
Publisher: name: RWTH Aachen University
Year: 2020

description: 12th International Conference on Knowledge Discovery and Information Retrieval, KDIR 2020, , 2 Nov 2020 - 4 Nov 2020
Synthesis, experimental and theoretical characterization of an unsymmetrical bis-benzimidazolium nitrate salt
Creators: name: Özdemir, Namık
name: Karataş, Mert Olgun
name: Küçükbay, Hasan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Neuroscience
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Plant Biology
subject: FOS: Biological sciences
subject: 60506 Virology

description: A bis-benzimidazolium nitrate salt was isolated and then characterized by FT-IR, NMR, LC-MS and UV-Vis. spectroscopies and elemental analysis. Geometry of the compound has been confirmed by single crystal X-ray study. The electronic structure and solution spectra have been supported by DFT and TDDFT calculations at HSEH1PBE/cc-pVDZ level of theory. The two-dimensional fingerprint plots associated with the Hirshfeld surface analysis of the compound elegantly quantify the interactions within the crystal structure, revealing significant similarities in the interactions. Structural parameters and spectroscopic properties of the compound are well represented by DFT and TD-DFT calculations.
Can virtuality be protective of team trust? Conflict and effectiveness in hybrid teams
Creators: name: Alves, Marta P.
name: Dimas, Isabel D.
name: Lourenço, Paulo R.
name: Rebelo, Teresa
name: Peñarroja, Vicente
name: Gamero, Nuria
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Molecular Biology
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Virtuality is noticeably present in organisations and influences the way people interact within teams. This study involved 104 organisational teams with some degree of virtuality and intends to analyze a moderated-mediation model in which virtuality moderates the indirect effect of team conflict on team effectiveness and innovation through team trust. First, results reveal that the negative association between conflict and team trust was significant for task conflict only in teams with low virtuality, and for relationship conflict was significant under low and moderate levels of virtuality. Finally, findings indicate that virtuality moderated the negative mediated relationship between both task and relationship team conflict and team effectiveness only through cognitive trust. Overall, the findings suggest that virtuality may protect team trust from the negative effects of conflict, and they point to the key role of cognitive trust as an antecedent of team effectiveness in hybrid teams.
title: Stromatolite-like structures within microbially laminated sandstones of the Paleoarchean Moodies Group, Barberton Greenstone Belt, South Africa
Creators: name: Heubeck, Christoph
name: Reimann, Sebastian
name: Homann, Martin
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
We report abundant small calcareous mounds associated with fossilized kerogenous microbial mats in tidal-facies sandstones of the predominantly siliciclastic Moodies Group (ca. 3.22 Ga) of the Barberton Greenstone Belt (BGB), South Africa and Eswatini. Most of the bulbous, internally microlaminated mounds are several cm in diameter and formed at the sediment-water interface contemporaneous with sedimentation. They originally consisted of Fe-Mg-Mn carbonate which is now largely silicified; subtle internal compositional laminations are composed of organic matter and sericite. Their presence for >6 km along strike, their restriction to the inferred photic zone, and the internal structure suggest that mineral precipitation was induced by photosynthetic microorganisms. Similar calcareous mounds in this unit also occur within and on top of fluid-escape conduits, suggesting that carbonate precipitation may either have occurred abiogenically or involved chemotrophic metabolism(s) utilizing the oxidation of organic matter, methane, or hydrogen, the latter possibly generated by serpentinization of underlying ultramafic rocks. Alternatively or additionally, carbonate may have precipitated abiotically where heated subsurface fluids, sourced by the intrusion of a major Moodies-age sill, reached the tidal flats. In summary, precipitation mechanisms may have been variable; the calcareous mounds may represent “hybrid carbonates” that may have originated from the small-scale overlap of bioinduced and abiotic processes in space and time. Significantly, the widespread occurrence of these stromatolite-like structures in a fully siliciclastic, high-energy tidal setting broadens search criteria in the search for life on Mars while their possible hybrid origin challenges our ability to unambiguously identify a biogenic component.
title: Διερεύνηση παραγόντων πρόκλησης αστικών συμβάντων πλημμύρας μέσω χωρικής στατιστικής ανάλυσης
title: Investigation on factors controlling urban flooding through spatial analysis
titleType: AlternativeTitle
Creators: name: Αρμενιάκου, Χρυσούλα Σοφια
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2021
Subjects: Πλημμύρα
Αττική
Μοντέλα παλινδρόμησης
Συστήματα γεωγραφικών πληροφοριών

description: Στόχος της παρούσας Διπλωματικής εργασίας είναι η διερεύνηση παραγόντων που συνδέονται με την εκδήλωση πλημμυρών σε αστικό περιβάλλον, μέσω της αξιοποίησης των δυνατοτήτων που παρέχουν τα συστήματα γεωγραφικών πληροφοριών για την εφαρμογή μεθόδων χωρικής στατιστικής ανάλυσης. Συγκεκριμένα εξετάζεται το ακραίο περιστατικό πλημμύρας που έπληξε τον Οκτώβριο του 2014 την Αθήνα, κυρίως τις περιοχές της Δυτικής Αθήνας. Για την έρευνα αξιοποιείται ένα σύνολο δεδομένων, όπως οι 10λεπτες καταγραφές βροχόπτωσης από εγκατεστημένους βροχομετρικούς σταθμούς στην ευρύτερη περιοχή και τα αστικά συμβάντα πλημμύρας, δηλαδή οι κλήσεις που δέχεται η πυροσβεστική υπηρεσία για άντληση υδάτων σε ιδιοκτησίες λόγω πλημμύρας που προκλήθηκε εξαιτίας της ισχυρής βροχόπτωσης. Δεδομένης της θέσης των συμβάντων, δύναται να καθοριστεί η τιμή μιας σειράς στατικών και δυναμικών παραγόντων που συνδέονται με το φαινόμενο της πλημμύρας, οι οποίοι, καθώς είναι χωρικά μεταβαλλόμενοι - ή και χρονικά, στην περίπτωση των δυναμικών -, μπορούν να εκφραστούν σε μορφή γεωχωρικών δεδομένων και να αξιοποιηθούν στην κατεύθυνση της στατιστικής ανάλυσης, για την εξαγωγή συμπερασμάτων αναφορικά με το βαθμό συσχέτισης και τελικά συμβολής τους στο φαινόμενο της πλημμύρας. Στο πλαίσιο της εργασίας εφαρμόστηκε πολλαπλή γραμμική παλινδρόμηση και λογιστική παλινδρόμηση για την εξαγωγή μοντέλου που θα εκφράζει σε επίπεδο φατνίου το μέγεθος της πλημμύρας και το ενδεχόμενο εμφάνισής της αντίστοιχα. Η διερεύνηση πραγματοποιήθηκε για διάφορους συνδυασμούς παραγόντων και για διαφορετικό μέγεθος φατνίου. Τα αποτελέσματα που προκύπτουν είναι σύμφωνα με ανάλογες εργασίες της διεθνούς βιβλιογραφίας και ανοίγουν το δρόμο για περαιτέρω διερεύνηση, λαμβάνοντας υπόψη μεγαλύτερο αριθμό παραγόντων, αλλά και εφαρμόζοντας την ανάλυση για άλλα επεισόδια βροχής-πλημμύρας, και σε διαφορετικά περιβάλλοντα.
Mitigating crowded transportation terminals nearby mega-sports events
Creators: name: Elkhouly, Reem
name: Tamaki, Emi
name: Iwasaki, Ken
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Hosting mega sports events in large cities worldwide surges the number of visitors. Congestion is observed at subway, bus, and train stations nearby the sports venues by the end of every competition. We propose two techniques for crowd-control around large sports events. We use Augmented Reality(AR) technology and hand gestures detecting wearable devices for two purposes. First, post-event congestion peak avoidance at the nearest station by passengers' arrival rate reduction. Attraction spots, where fans can enjoy secondary activities such as remote-sightseeing using VR, can be established in arbitrary locations around the venue. This is to postpone some fans' arrival at the nearest station and to encourage walking towards another nearby one. Second, accelerating the inside-station trip to increase passengers' departure rate. Fans moving in groups can use the wearable device and the coupled smartphone application for intra-station navigation and quick way-finding while avoiding getting separated by the crowds. We also present two agent-based simulations to indicate the efficacy of both techniques in mitigating stations overcrowding. The evaluation shows that providing attraction spots reduced fans' arrival at the nearest station to the event and the arrival rates at all stations. Moreover, the navigation of large-size groups was enhanced in crowded stations.
Map #447, Site 5MT10647, Nonstructure 238, Nonstructure 240, Arbitrary Unit 219, and Arbitrary Unit 245, Stratigraphic Profile
Creators: name: DeVos, Jim
Year: 2018
Subjects: subject: Southwestern Colorado
valueUri: https://core.tdar.org/browse/geographic-keyword/2810/southwestern-colorado
subject: Southwestern US
valueUri: https://core.tdar.org/browse/geographic-keyword/84604/southwestern-us
subject: Basketmaker III
valueUri: https://core.tdar.org/browse/temporal-keyword/78/basketmaker-iii
subject: Pueblo I
valueUri: https://core.tdar.org/browse/temporal-keyword/54/pueblo-i
subject: Pueblo II
valueUri: https://core.tdar.org/browse/temporal-keyword/55/pueblo-ii
subject: 5MT10647
valueUri: https://core.tdar.org/browse/site-name/118013/5mt10647
subject: Dillard Site
valueUri: https://core.tdar.org/browse/site-name/118012/dillard-site

description: Site 5MT10647, Nonstructure 238, Nonstructure 240, Arbitrary Unit 219, and Arbitrary Unit 245, Stratigraphic Profile
title: A hot, hydrothermally-fed microbial tidal flat in the Paleoarchean Moodies Group, Barberton Greenstone Belt, South Africa?
Creators: name: Stengel, Hannes
name: Heubeck, Christoph
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
Sandy alluvial-, deltaic-, and tidal-facies sediments of the Paleoarchean Moodies Group (ca. 3,220 Ma) are preserved several km thick in the central Barberton Greenstone Belt, interspersed with diverse units representing substantial mafic to intermediate (sub-)volcanism. Densely biolaminated sandstones feature common, up to 6 m high fluid-escape structures which fed small sand volcanoes during prolonged and/or recurring discharge of gases, liquids, and solids. The to-date highest documented concentration of fluid-escape structures occurs in a single, largely silicified unit of tidal-facies sandstones ca. 150 m thick, traceable along strike for ca. 14 km and located stratigraphically ca. 1 km above the Lomati River Sill, a 15 km long mafic sill of Moodies intrusive age. Fluid-escape conduits are filled by sand, sericitic clay and fine-grained organic matter. Semiquantitative XRF scanning of several slabbed fluid-escape structures indicates that conduits are enriched in Fe, Cr, Ti, and Mg in comparison to the mean composition of adjacent beds, suggesting that fluid-escape structures may not only have formed due to overpressure build-up from decaying microbial mats in the shallow subsurface but also resulting from release of hydrothermal fluids generated in a thermal aureole above the cooling sill. This inference is also supported by sediment textures characteristic of argillaceous and sericitic alteration, Raman temperatures ca. 50 - 100°C above the regional maximum metamorphic temperature of 320 - 370°C, and associated peperites nearby. Surficial hydrothermal activity in the tidal zone would have likely boosted microbial growth. Surficial pre-compaction carbonation and silicification greatly facilitated the preservation of delicate microbial mats.
Sensory marketing: η δύναμη των αισθήσεων στις πωλήσεις
Creators: name: Αγγαρίτη, Γεωργία
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2021
Subjects: subject: Sensory marketing
subject: Neuromarketing
subject: Συμπεριφορά καταναλωτή

description: Η παρούσα εργασία αποτελεί μία ακαδημαϊκή μελέτη, σχετικά με τον αμφιλεγόμενο τομέα του Sensory Marketing, και με τον τρόπο με τον οποίο οι επιχειρήσεις εκμεταλλεύονται όλα τα διαθέσιμα σύγχρονα εργαλεία που έχουν στην διάθεση τους για να αυξήσουν το ανταγωνιστικό τους πλεονέκτημα. Για να μπορέσουμε να έχουμε πιο σωστά αποτελέσματα, έγινε μελέτη περίπτωσης, πιο συγκεκριμένα, με την Nema Resorts Wear, ένα ελληνικό brand ρούχων, και πραγματοποιήθηκαν ημι-δομημένες συνεντεύξεις με τον ιδιοκτήτη της επιχείρησης. Παράλληλα έχει γίνει βιβλιογραφική ανασκόπηση, η οποία καλύπτει όλους τους τομείς του αισθητηριακού marketing, της καταναλωτικής συμπεριφοράς, αλλά και της νευροεπιστήμης, έτσι ώστε ο αναγνώστης να έχει πλήρη επίγνωση για το θέμα και τον τρόπο προσέγγισης του. Τέλος για να υπάρχει μία πιο εμπεριστατωμένη ματιά, πραγματοποιήθηκε και ποσοτική έρευνα, σε ένα δείγμα 100 ατόμων, όπου μέσα από 10 ερωτήσεις κλειστού τύπου, δόθηκαν απαντήσεις σχετικά το αισθητηριακό marketing και κατά πόσο μετράει για τους καταναλωτές. Σύμφωνα με τα αποτελέσματα της ποιοτικής μελέτης που πραγματοποιήθηκε, οι περισσότερες ελληνικές επιχειρήσεις οι οποίες δραστηριοποιούνται στον τομέα της μόδας, έχουν ξεκινήσει να εφαρμόζουν το marketing των αισθήσεων, αλλά σε όχι τόσο μεγάλο βαθμό, καθώς είναι μία προσέγγιση η οποία δεν έχει τύχει μεγάλης αναγνώρισης και υπάρχει ένα μεγάλο κενό έρευνας από την πλευρά των επιχειρήσεων, όσον αφορά αυτό το κομμάτι. Παρόλα αυτά πολλές μικρές επιχειρήσεις αλλά και νέα brands, οι οποίοι δραστηριοποιούνται σε έναν ιδιαίτερα ανταγωνιστικό χώρο έχουν ξεκινήσει να πειραματίζονται και να αφήνουν το δικό τους αποτύπωμα με μεγάλη επιτυχία. Τα αποτελέσματα της ποσοτικής μελέτης που πραγματοποιήθηκε, ανέδειξαν την ανάγκη που υπάρχει στην σύγχρονη αγορά για την μεγαλύτερη εφαρμογή του αισθητηριακού marketing, καθώς οι περισσότεροι καταναλωτές, δυνητικά, θα δώσουν επιπλέον χρήματα σε ένα μαγαζί όπου η μουσική και το περιβάλλον είναι ευχάριστη, θα έχει άμεση επαφή με τα υφάσματα και θα μπορεί να υπάρχει διάδραση μεταξύ επιχείρησης και καταναλωτή.