cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Pericentric Chromatin Is Organized into an Intramolecular Loop in Mitosis
Creators: name: Joglekar, Ajit
name: Yeh, Elaine
name: Bouck, David
name: Haase, Julian
name: Bloom, Kerry S.
name: Salmon, E.D.
name: Bond, Lisa
name: Paliulis, Leocadia V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Cohesin proteins link sister chromatids and provide the basis for tension between bi-oriented sister chomatids in mitosis. Cohesin is concentrated at the centromere region of the chromosome despite the fact that sister centromeres can be separated by 800nm in vivo. The function of cohesin at sites of separated DNA is unknown.
ÓZLESTIRIW YAMASA RASTRATA JOLI MENEN TALAN-TARAJ ETIW JINAYATINIŃ JINAYATLI-HUQIQIY KLASSIFIKACIYASI
Creators: name: Uteeva, Baǵdagúl
Publisher: name: Zenodo
Year: 2023

description: Ózlestiriw yamasa rastrata joli menen talan-taraj etiw jinayatiniń jinayatli-huqiqiy klassifikaciyasi haqqında sóz etildi.
Perpetual Lease Contract from Olympia
Creators: name: Raggiunti, Luca
Publisher: name: Fondazione Università Ca’ Foscari Venezia, Italia
Year: 2022

description: In the sanctuary of Zeus at Olympia, a bronze plate was found in early March 1879, which must have been affixed to a wall of the sanctuary, as the preserved corner holes show. The inscription is written in Elean dialect and can be dated on palaeographic grounds to the last quarter of the 5th century BC. It is a perpetual lease contract for a plot of land in Salmone. The interpretation of the document is problematic: the display of the bronze plate in Olympia and the perpetual duration of the lease are in fact a unicum in a contract that, in light of the linguistic data, is believed to have been concluded between two private individuals.
description: Axon
φ-meson production at forward rapidity in Au+Au collisions at 200 GeV
Creators: name: Acharya, Uttam
Publisher: name: Zenodo
Year: 2022
Subjects: hq22
phenix
φ
forward-rapidity
au+au
qgp
strange
dimuon
dielectron
raa
nuclear
modification
d+au
mid-rapidity

description: Talk presented at the Hot Quarks 2022 workshop
Long-time behavior of 3 dimensional Ricci flow -- Introduction
Creators: name: Bamler, Richard H.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Differential Geometry (math.DG)
subject: Analysis of PDEs (math.AP)
subject: Geometric Topology (math.GT)
subject: FOS: Mathematics

description: In the following series of papers we analyze the long-time behavior of 3 dimensional Ricci flows with surgery. Our main result will be that if the surgeries are performed correctly, then only finitely many surgeries occur and after some time the curvature is bounded by $C t^{-1}$. This result confirms a conjecture of Perelman. In the course of the proof, we also obtain a qualitative description of the geometry as $t \to \infty$.
description: 16 pages, 3 figures
The Spinster Homolog, Two of Hearts, Is Required for Sphingosine 1-Phosphate Signaling in Zebrafish
Creators: name: Ober, Elke A.
name: Jin, Suk-Won
name: Stainier, Didier Y.R.
name: Yelon, Deborah
name: Brand-Arzamendi, Koroboshka
name: Osborne, Nick
name: Verkade, Heather
name: Holtzman, Nathalia Glickman
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The bioactive lipid sphingosine 1-phosphate (S1P) and its G protein-coupled receptors play critical roles in cardiovascular, immune and neural development and function [1–6]. Despite its importance, many questions remain about S1P signaling, including how S1P, which is synthesized intracellularly, is released from cells. Mutations in the zebrafish gene encoding the S1P receptor Miles Apart (Mil)/S1P2 disrupt the formation of the primitive heart tube [5]. We find that mutations of another zebrafish locus, two of hearts (toh), cause phenotypes that are morphologically indistinguishable from those seen in mil/s1p2 mutants. Positional cloning of toh reveals that it encodes a member of the Spinster-like family of putative transmembrane transporters. The biological functions of these proteins are poorly understood, although phenotypes of the Drosophila spinster and zebrafish not really started mutants suggest that these proteins may play a role in lipid trafficking [7, 8]. Through gain- and loss-of-function analyses, we show that toh is required for signaling by S1P2. Further evidence indicates that Toh is involved in the trafficking or cellular release of S1P.
Human Myo19 Is a Novel Myosin that Associates with Mitochondria
Creators: name: Quintero, Omar A.
name: Feliu, Marianela
name: Kortan, Melisa B.
name: Case, Lindsay B.
name: Adikes, Rebecca C.
name: Rengarajan, Michelle
name: Lier, Audun J.
name: Cheney, Richard E.
name: Panaretos, Niki S.
name: Slater, Stephanie Q.
name: DiVito, Melinda M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Mitochondria are pleomorphic organelles [1, 2] that have central roles in cell physiology. Defects in their localization and dynamics lead to human disease [3-5]. Myosins are actin-based motors that power processes such as muscle contraction, cytokinesis, and organelle transport [6]. Here we report the initial characterization of myosin-XIX (Myo19), the founding member of a novel class of myosin that associates with mitochondria. The 970aa heavy chain consists of a motor domain, three IQ motifs, and a short tail. Myo19 mRNA is expressed in multiple tissues and antibodies to human Myo19 detect a ∼109kD band in multiple cell lines. Both endogenous Myo19 and GFP-Myo19 exhibit striking localization to mitochondria. Deletion analysis reveals that the Myo19 tail is necessary and sufficient for mitochondrial localization. Expressing full-length GFP-Myo19 in A549 cells reveals a remarkable gain-of-function where the majority of the mitochondria move continuously. Moving mitochondria travel for many microns with an obvious leading end and distorted shape. The motility and shape-change are sensitive to latrunculin B, indicating that both are actin-dependent. Expressing the GFP-Myo19 tail in CAD cells resulted in decreased mitochondrial run lengths in neurites. These results suggest that this novel myosin functions as an actin-based motor for mitochondrial movement in vertebrate cells.
“To Say Almost the Same Thing”. Metamorphosis of a Vulgarisation
Creators: name: Gualdo, Irene
Publisher: name: Fondazione Università Ca’ Foscari Venezia, Italia
Year: 2022

description:

This essay highlights various open methodological issues that the editors of medieval volgarizzamenti have to face when they intend to publish a critical edition, such as the need to trace different witnesses back to the same archetype despite the often considerable variants introduced by the copyists, or the crucial choice concerning the most suitable technical terms to describe a complex textual situation. Subsequently, focusing on the case study represented by the dossier of volgarizzamenti of the Liber de doctrina dicendi et tacendi by Albertano da Brescia, the article shows and explains some of the lexical and methodological choices made to publish their critical edition.

description: TranScript
Imaging Myosin-X at the Single-Molecule Level Reveals a Novel Form of Motility in Filopodia
Creators: name: Cheney, Richard E.
name: Kerber, Michael L.
name: Jacobs, Damon T.
name: Yin, Taofei
name: Sousa, Aurea D.
name: Quintero, Omar A.
name: Dunn, Brian D.
name: Campagnola, Luke
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Although many proteins, receptors, and viruses are transported rearward along filopodia by retrograde actin flow[1-3], it is less clear how molecules move forward in filopodia. Myosin-X (Myo10) is an actin-based motor hypothesized to use its motor activity to move forward along actin filaments to the tips of filopodia[4]. Here we use a sensitive total internal reflection fluorescence (TIRF) microscopy system to directly visualize the movements of GFP-Myo10. This reveals a novel form of motility at or near the single-molecule level in living cells wherein extremely faint particles of Myo10 move in a rapid and directed fashion towards the filopodial tip. These fast forward movements occur at ∼600 nm/s over distances of up to ∼10 μm and require Myo10 motor activity and actin filaments. As expected for imaging at the single-molecule level, the faint particles of GFP-Myo10 are diffraction-limited, have an intensity range similar to single GFP molecules, and exhibit stepwise bleaching. Faint particles of GFP-Myo5a can also move towards the filopodial tip, but at a slower characteristic velocity of ∼250 nm/s. Similar movements were not detected with GFP-Myo1a, indicating that not all myosins are capable of intrafilopodial motility. These data indicate the existence of a novel system of long-range transport based on the rapid movement of myosin molecules along filopodial actin filaments.
Long-time behavior of 3 dimensional Ricci flow -- A: Generalizations of Perelman's long-time estimates
Creators: name: Bamler, Richard H.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Differential Geometry (math.DG)
subject: Analysis of PDEs (math.AP)
subject: Geometric Topology (math.GT)
subject: FOS: Mathematics

description: This is the first of a series of papers on the long-time behavior of 3 dimensional Ricci flows with surgery. In this paper we first fix a notion of Ricci flows with surgery, which will be used in this and the following three papers. Then we review Perelman's long-time estimates and generalize them to the case in which the underlying manifold is allowed to have a boundary. Eventually, making use of Perelman's techniques, we prove new long-time estimates, which hold whenever the metric is sufficiently collapsed.
description: 58 pages, revised version
In Vivo Protein Architecture of the Eukaryotic Kinetochore with Nanometer Scale Accuracy
Creators: name: Salmon, E.D.
name: Joglekar, Ajit P.
name: Bloom, Kerry
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The kinetochore is a macromolecular protein machine [1] that links centromeric chromatin to the plus-ends of one or more microtubules (MT), and segregates chromosomes during cell division. Its core structure consists of eight multi-component protein complexes, most of which are conserved in all eukaryotes. We use an in vivo two-color fluorescence microscopy technique to determine, for the first time, the location of these proteins along the budding yeast kinetochore axis at nanometer resolution. Together with kinetochore protein counts [2, 3], these localizations predict the 3-D protein architecture of a kinetochore-microtubule attachment, and provide new functional insights. We also find that the kinetochore becomes much shorter in anaphase as metaphase tension is lost. Shortening is mainly due to a decrease in the length of the Ndc80 complex, which may result either from intra-molecular bending of the Ndc80 complex at the kink within the stalk region of the Ndc80/Nuf2 dimer [4, 5] or from a change in its orientation relative to the microtubule axis. Conformational changes within the Ndc80 and Mtw1 complexes may serve as mechanical cues for tension-dependent regulation of MT attachment and the spindle assembly checkpoint. The geometry of the core structure of the budding yeast kinetochore reported here is remarkably similar to that found in mammalian kinetochores, indicating that kinetochore structure is conserved in eukaryotes with either point or regional centromeres.
Long-time behavior of 3 dimensional Ricci flow -- B: Evolution of the minimal area of simplicial complexes under Ricci flow
Creators: name: Bamler, Richard H.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Differential Geometry (math.DG)
subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: In this second part of a series of papers on the long-time behavior of Ricci flows with surgery, we establish a bound on the evolution of the infimal area of simplicial complexes inside a 3-manifold under the Ricci flow. This estimate generalizes an area estimate of Hamilton, which we will recall in the first part of the paper. We remark that in this paper we will mostly be dealing with non-singular Ricci flows. The existence of surgeries will not play an important role.
description: 40 pages, revised version
Analysis of the Most Frequent Morphosyntatic Errors in the Italian of Egyptian Students
Creators: name: Ali, Mai Morsy Tawfik
Publisher: name: Fondazione Università Ca’ Foscari Venezia, Italia
Year: 2022

description:

This research aims to examine from an analytical perspective the most frequent morphosyntactic errors that Egyptian students commit while learning the Italian language. The discussion of this topic is not a mere list of students’ errors, rather it focuses on the problem of error analysis and on the other related problems, such as the typology, the frequency and, finally, the causes of such errors. We started from the fact that in the learning phases of an SL, most students encounter difficulties especially in written production. The correction of the works produced by learners allows us to study the causes of certain errors and to isolate, analyse and correct them.

description: EL.LE
A Review on Digitalisation Approaches for Battery Manufacturing Processes
Creators: name: Dermenci, K. Burak
name: Dammala, Pradeep Kumar
name: Yadav, Poonam
name: Kathribail, Anish Raj
name: Van Mierlo, Joeri
name: Berecibar, Maitane
Publisher: name: Zenodo
Year: 2023
Subjects: Batteries
Li-ion batteries
Manufacturing
Digitalisation
Artificial Intelligence
LIB

description: Manufacturing of Li-ion batteries (LIBs) is difficult, because of some interdependent electrochemical kinetics involved in its chemistry. It became one of the challenging aspects as it is time consuming and needs to be updated while new materials and methodologies are coming. Introduction of digitalised tools has the potential to overcome such challenges quickly. It will reduce the dependency on hands-on experience for optimisation of LIB parameters and pave the way for a successful large-scale implementation. In this study, digitalisation approaches that are being implemented and soon-to-be implemented are reviewed by means of Artificial Intelligence (AI), Machine Learning (ML) and Internet of Things (IoT) while putting a particular focus in the battery-making processes.
description: {"references": ["Witt, D. et al.Myth and Reality of a Universal Lithium-Ion Battery Electrode Design Optimum: A Perspective and Case Study. Energy Technol.9, (2021)", "Liu Z. et. al. Mesoscale Elucidation of the Influence of Mixing Sequence in Electrode Processing Langmuir 2014, 30, 50, 15102\u201315113", "Forouzan, M., et al. Experiment and simulation of the fabrication process of lithium-ion battery cathodes for determining microstructure and mechanical properties. Journal of Power Sources, 2016, 312: 172-183", "Laue, V., et al.Joint structural and electrochemical modeling: Impact of porosity on lithium-ion battery performance. ElectrochimicaActa, 2019, 314: 20-31", "Bayatinejad, M. et. al..Investigatingthe effects of tabs geometry and current collectorsthickness of lithium-ion battery with electrochemical-thermal simulation. Journal of Energy Storage, 2021, 43: 103203"]}
Notch Signaling Functions as a Cell-Fate Switch between the Endothelial and Hematopoietic Lineages
Creators: name: Chong, Shang-Wei
name: Stainier, Didier Y.R.
name: Jin, Suk-Won
name: Jiang, Yun-Jin
name: Lee, Christina Y.
name: Vogeli, Kevin M.
name: Kim, Se-Hee
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Recent studies have begun to elucidate how the endothelial lineage is specified from the nascent mesoderm. However, the molecular mechanisms which regulate this process remain largely unknown. We hypothesized that Notch signaling might play an important role in specifying endothelial progenitors from the mesoderm, given that this pathway acts as a bipotential cell-fate switch on equipotent progenitor populations in other settings. We found that zebrafish embryos with decreased levels of Notch signaling exhibited a significant increase in the number of endothelial cells, whereas embryos with increased levels of Notch signaling displayed a reduced number of endothelial cells. Interestingly, there is a concomitant gain of endothelial cells and loss of erythrocytes in embryos with decreased Notch activity, without an effect on cell proliferation or apoptosis. Lineage-tracing analyses indicate that the ectopic endothelial cells in embryos with decreased Notch activity originate from mesodermal cells that normally produce erythrocyte progenitors. Taken together, our data suggest that Notch signaling negatively regulates the number of endothelial cells by limiting the number of endothelial progenitors within the mesoderm, probably functioning as a cell-fate switch between the endothelial and the hematopoietic lineages.
Generalized and degenerate Whittaker models
Creators: name: Gomez, Raul
name: Gourevitch, Dmitry
name: Sahi, Siddhartha
Publisher: name: arXiv
Year: 2015
Subjects: subject: Representation Theory (math.RT)
subject: FOS: Mathematics
subject: 20G05, 20G20, 20G25, 20G30, 20G35, 22E27, 22E46, 22E50, 22E55, 17B08

description: We study generalized and degenerate Whittaker models for reductive groups over local fields of characteristic zero (archimedean or non-archimedean). Our main result is the construction of epimorphisms from the generalized Whittaker model corresponding to a nilpotent orbit to any degenerate Whittaker model corresponding to the same orbit, and to certain degenerate Whittaker models corresponding to bigger orbits. We also give choice-free definitions of generalized and degenerate Whittaker models. Finally, we explain how our methods imply analogous results for Whittaker-Fourier coefficients of automorphic representations. For $\mathrm{GL}_n(F)$ this implies that a smooth admissible representation $π$ has a generalized Whittaker model $\mathcal{W}_{\mathcal{O}}(π)$ corresponding to a nilpotent coadjoint orbit $\mathcal{O}$ if and only if $\mathcal{O}$ lies in the (closure of) the wave-front set $\mathrm{WF}(π)$. Previously this was only known to hold for $F$ non-archimedean and $\mathcal{O}$ maximal in $\mathrm{WF}(π)$, see [MW87]. We also express $\mathcal{W}_{\mathcal{O}}(π)$ as an iteration of a version of the Bernstein-Zelevinsky derivatives [BZ77,AGS15a]. This enables us to extend to $\mathrm{GL_n}(\mathbb{R})$ and $\mathrm{GL_n}(\mathbb{C})$ several further results from [MW87] on the dimension of $\mathcal{W}_{\mathcal{O}}(π)$ and on the exactness of the generalized Whittaker functor.
description: 36 pages. v4: formulations of Theorem C and Corollary 3.3.7 corrected. v5: minor typo corrections
Genetic polymorphisms of diabetes-related genes, their interaction with diabetes status, and breast cancer incidence and mortality: The Long Island Breast Cancer Study Project
Creators: name: Neugut, A.I.
name: Cleveland, R.J.
name: Parada, H., Jr.
name: Gammon, M.D.
name: Martinez, M.E.
name: Santella, R.M.
name: Stevens, J.
name: North, K.E.
name: Teitelbaum, S.L.
Publisher: name: John Wiley and Sons Inc.
Year: 2019

description: To examine 143 diabetes risk single nucleotide polymorphisms (SNPs), identified from genome-wide association studies, in association with breast cancer (BC) incidence and subsequent mortality. A population-based sample of Caucasian women with first primary invasive BC (n = 817) and controls (n = 1021) were interviewed to assess diabetes status. Using the National Death Index, women with BC were followed for >18 years during which 340 deaths occurred (139 BC deaths). Genotyping was done using DNA extracted from blood samples. We used unconditional logistic regression to estimate age-adjusted odds ratios and 95% confidence intervals (CIs) for BC incidence, and Cox regression to estimate age-adjusted hazard ratios and CIs for all-cause and BC-specific mortality. Twelve SNPs were associated with BC risk in additive genotype models, at α = 0.05. The top three significant SNPs included SLC30A8-rs4876369 (P = 0.0034), HHEX-rs11187146 (P = 0.0086), and CDKN2A/CDKN2B-rs1333049 (P = 0.0094). Diabetes status modified the associations between rs4876369 and rs2241745 and BC incidence, on the multiplicative interaction scale. Six SNPs were associated with all-cause (CDKAL1-rs981042, P = 0.0032; HHEX-rs1111875, P = 0.0361; and INSR-rs919275, P = 0.0488) or BC-specific (CDKN2A/CDKN2B-rs3218020, P = 0.0225; CDKAL1-rs981042, P = 0.0246; and TCF2/HNF1B-rs3094508, P = 0.0344) mortality in additive genotype models, at α = 0.05. Genetic polymorphisms that increase the risk of developing diabetes may also increase the risk of developing and dying from BC.
Spindle Assembly in the Absence of a RanGTP Gradient Requires Localized CPC Activity
Creators: name: Maresca, Thomas J.
name: Salmon, Edward D.
name: Mitchison, Timothy J.
name: Gatlin, Jesse C.
name: Ohi, Ryoma
name: Groen, Aaron C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: During animal cell division, a gradient of GTP-bound Ran is generated around mitotic chromatin [1, 2]. It is generally accepted that this RanGTP gradient is essential for organizing the spindle since it locally activates critical spindle assembly factors [3–5]. Here, we show in Xenopus egg extract, where the gradient is best characterized, that spindles can assemble in the absence of a RanGTP gradient. Gradient-free spindle assembly occurred around sperm nuclei but not around chromatin-coated beads and required the chromosomal passenger complex (CPC). Artificial enrichment of CPC activity within hybrid bead arrays containing both immobilized chromatin and the CPC supported local microtubule assembly even in the absence of a RanGTP gradient. We conclude that RanGTP and the CPC constitute the two major molecular signals that spatially promote microtubule polymerization around chromatin. Furthermore, we hypothesize that the two signals mainly originate from discreet physical sites on the chromosomes to localize microtubule assembly around chromatin: a RanGTP signal from any chromatin, and a CPC-dependent signal predominantly generated from centromeric chromatin.
On Ἀττικός (e Ἀττική) in Ancient Attestations
Creators: name: Vox, Onofrio
Publisher: name: Fondazione Università Ca’ Foscari Venezia, Italia
Year: 2022

description:

The early literary occurrences of Ἀττικός/Ἀττική (from Sol. fr. 2.6 and 30.11 G.-P.2, Alc. fr. 401B V./L., Aesch. Eum. 681) show that this ethnicon, compared with Ἀθηναῖος, is the official name of any Athenian citizen in international context.

description: Lexis
The State of Industry 4.0 in the Australian Construction Industry: An Examination of Industry and Academic Point of View
Creators: name: Soltani, S
name: Maxwell, D
name: Rashidi, Ali
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 3301
subject: Architecture
subject: FOS: Civil engineering
classificationCode: 4005
subject: Civil engineering
classificationCode: 3302
subject: Building

description: The aim of this study is to provide an overview of the current state of Industry 4.0 (IR 4.0) with regard to construction in Australia and to identify the key factors that are driving and hindering its adoption. A literature review and desktop review were conducted to extract mainstream topics, followed by a two-folded workshop designed with a multidisciplinary team of academics, as well as representatives of mainstream firms and peak bodies from the construction value chain. Our study has highlighted the importance of considering both technological and human-related factors in the adoption of IR 4.0 to address barriers that have been traditionally overlooked, and work towards a more successful and holistic implementation of this transformative paradigm. By considering the social aspects of construction, prioritizing data-driven approaches with a focus on privacy and ethics, and emphasizing integration, these facilitators contribute to the effective implementation and success of IR 4.0 in the construction industry. The findings of this study have significant implications for the construction industry in Australia. Addressing the barriers to digital construction adoption and embracing IR 4.0 technologies can help the industry to improve productivity, reduce costs, and enhance sustainability. Additionally, investing in education and training can help to build the necessary skills and capabilities needed to drive the industry forward in the digital age.
Long-time behavior of 3 dimensional Ricci flow -- D: Proof of the main results
Creators: name: Bamler, Richard H.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Differential Geometry (math.DG)
subject: Analysis of PDEs (math.AP)
subject: Geometric Topology (math.GT)
subject: FOS: Mathematics

description: This is the fourth and last part of a series of papers on the long-time behavior of 3 dimensional Ricci flows with surgery. In this paper, we prove our main two results. The first result states that if the surgeries are performed correctly, then the flow becomes non-singular eventually and the curvature is bounded by $C t^{-1}$. The second result provides a qualitative description of the geometry as $t \to \infty$.
description: 100 pages, 15 figures, revised version
MOND-like acceleration in integrable Weyl geometric gravity
Creators: name: Scholz, Erhard
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this paper a Weyl geometric scalar tensor theory of gravity with scalar field $Φ$ and scale invariant cubic ("aquadratic") kinetic Lagrangian is introduced. Einstein gauge (comparable to Einstein frame in Jordan-Brans-Dicke theory) is most natural for studying trajectories. In it, the Weylian scale connection induces an additional acceleration which in the weak field, static, low velocity limit acquires the deep MOND form of Milgrom/Bekenstein's gravity. The energy momentum of $Φ$ leads to another add on to Newton acceleration. Both additional accelerations together imply a MOND-ian phenomenology of the model. It has unusual transition functions. They imply higher phantom energy density than in the case of the more common MOND models with transition functions $μ_1(x), \, μ_2(x)$. A considerable part of it is due to the scalar field's energy density which, in our model, gives a scale and generally covariant expression for the self-energy of the gravitational field.
description: In v.4 the scalar field equation has been simplified by suppressing the B-terms (modification of the kinetic Lagrangian). This improves the MOND approximation considerably. The role of the "upper" transition regime has been made more explicit. 37 pp, 2 figures
Spindle Fusion Requires Dynein-Mediated Sliding of Oppositely Oriented Microtubules
Creators: name: Mitchison, Timothy J.
name: Danuser, Gaudenz
name: Maresca, Thomas J.
name: Gatlin, Jesse C.
name: Needleman, Daniel J.
name: Salmon, E.D.
name: Groen, Aaron C.
name: Matov, Alexandre
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Bipolar spindle assembly is critical for achieving accurate segregation of chromosomes. In the absence of centrosomes, meiotic spindles achieve bipolarity by a combination of chromosome initiated microtubule nucleation/stabilization and motor driven organization of microtubules. Once assembled, the spindle structure is maintained on a relatively long time scale despite the high turnover of the microtubules that comprise it. To study the underlying mechanisms responsible for spindle assembly and steady-state maintenance, we used microneedle manipulation of pre-assembled meiosis II spindles in Xenopus egg extracts.
Childhood obesity intervention studies: A narrative review and guide for investigators, authors, editors, reviewers, journalists, and readers to guard against exaggerated effectiveness claims
Creators: name: Oakes, J.M.
name: Kyle, T.K.
name: Dowla, S.
name: Dawson, J.A.
name: Gelman, A.
name: Keith, S.W.
name: Heymsfield, S.B.
name: Dhurandhar, N.V.
name: Bland, J.M.
name: Altman, D.G.
name: Thomas, D.M.
name: Jayawardene, W.
name: Baranowski, T.
name: Fontaine, K.R.
name: Stevens, J.
name: Brown, A.W.
name: Loken, E.
name: Allison, D.B.
Publisher: name: Blackwell Publishing Ltd
Year: 2019

description: Being able to draw accurate conclusions from childhood obesity trials is important to make advances in reversing the obesity epidemic. However, obesity research sometimes is not conducted or reported to appropriate scientific standards. To constructively draw attention to this issue, we present 10 errors that are commonly committed, illustrate each error with examples from the childhood obesity literature, and follow with suggestions on how to avoid these errors. These errors are as follows: using self-reported outcomes and teaching to the test; foregoing control groups and risking regression to the mean creating differences over time; changing the goal posts; ignoring clustering in studies that randomize groups of children; following the forking paths, subsetting, p-hacking, and data dredging; basing conclusions on tests for significant differences from baseline; equating “no statistically significant difference” with “equally effective”; ignoring intervention study results in favor of observational analyses; using one-sided testing for statistical significance; and stating that effects are clinically significant even though they are not statistically significant. We hope that compiling these errors in one article will serve as the beginning of a checklist to support fidelity in conducting, analyzing, and reporting childhood obesity research.
Glaube als Transformationsprozeß
Creators: name: Brachel, Hans-Ulrich Von
name: Fetz, Reto Luzius
name: Oser, Fritz
Publisher: name: Diakonia
Year: 1970

description: Diakonia, Bd. 14 Nr. 1 (1983): Diakonia, Band 14, Heft 1
Incidence of components of metabolic syndrome in the metabolically healthy obese over 9 years follow-up: The Atherosclerosis Risk in Communities study
Creators: name: Reynolds, K.R.
name: Bradshaw, P.T.
name: Ndumele, C.E.
name: Wagenknecht, L.E.
name: Stevens, J.
Publisher: name: Nature Publishing Group
Year: 2018

description: Background:Some obese adults are not afflicted by the metabolic abnormalities often associated with obesity (the 'metabolically healthy obese' (MHO)); however, they may be at increased risk of developing cardiometabolic abnormalities in the future. Little is known about the relative incidence of individual components of metabolic syndrome (MetSyn).Methods:We used data from a multicenter, community-based cohort aged 45-64 years at recruitment (the Atherosclerosis Risk In Communities study) to examine the first appearance of any MetSyn component, excluding waist circumference. Body mass index (BMI, kg m '2) and cardiometabolic data were collected at four triennial visits. Our analysis included 3969 adults who were not underweight and free of the components of MetSyn at the initial visit. Participants were classified as metabolically healthy normal weight (MHNW), overweight (MHOW) and MHO at each visit. Adjusted hazard ratios (HR) and 95% confidence intervals were estimated with proportional hazards regression models.Results:The relative rate of developing each risk factor was higher among MHO than MHNW, with the strongest association noted for elevated fasting glucose (MHO vs MHNW, HR: 2.33 (1.77, 3.06)). MHO was also positively associated with elevated triglycerides (HR: 1.63 (1.27, 2.09)), low high-density lipoprotein-cholesterol (HR: 1.68 (1.32, 2.13)) and elevated blood pressure (HR: 1.54 (1.26, 1.88)). A similar, but less pronounced pattern was noted among the MHOW vs MHNW.Conclusions:We conclude that even among apparently healthy individuals, obesity and overweight are related to more rapid development of at least one cardiometabolic risk factor, and that elevations in blood glucose develop most rapidly.
The C. elegans Dosage Compensation Complex Propagates Dynamically and Independently of X Chromosome Sequence
Creators: name: Lieb, Jason D.
name: Dick, Lindsay L.
name: Ercan, Sevinç
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The C. elegans Dosage Compensation Complex (DCC) associates with both X chromosomes of XX animals to reduce X-linked transcript levels. Five DCC members are homologous to subunits of the evolutionarily conserved condensin complex, while two non-condensin subunits are required for DCC recruitment to X. Here, we investigated the molecular mechanism of DCC recruitment and spreading along X by examining gene expression and the binding patterns of DCC subunits in different stages of development, and in strains harboring X;autosome fusions. We show that DCC binding is dynamically specified according to gene activity during development, and that the mechanism of DCC spreading is independent of X-chromosome DNA sequence. Accordingly, in X;A fusion strains DCC spreading propagates from X-linked recruitment sites onto autosomal promoters as a function of distance. Quantitative analysis of spreading suggests that the condensin-like subunits spread from recruitment sites to promoters more readily than subunits involved in initial X-targeting. Via these mechanisms, a highly conserved chromatin complex is appropriated to accomplish domain-scale transcriptional regulation during development. Similarities to the X-recognition and spreading strategies used by the Drosophila DCC suggest mechanisms fundamental to chromosome-scale gene regulation.
Weak convergence of the Wojcik model
Creators: name: Endo, Takako
name: Konno, Norio
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We study "the Wojcik model" which is a discrete-time quantum walk (QW) with one defect in one dimension, introduced by Wojcik et al.. For the Wojcik model, we give the weak convergence theorem describing the ballistic behavior of the walker in the probability distribution in a rescaled position-space. In our previous studies, we obtained the time-averaged limit and stationary measures concerning localization for the Wojcik model. As a result, we get the mathematical expression of the whole picture of the behavior of the walker for the Wojcik model. Here the coexistence of localization and the ballistic spreading is one of the peculiar properties of one-dimensional QWs with one defect. Due to the coexistence, it has been strongly expected to utilize QWs to quantum search algorithms. In order to derive the weak convergence theorem, we take advantage of the generating function method. We emphasize that the time-averaged limit measure is symmetric for the origin, however, the weight function in the weak limit measure is asymmetric in general, which implies that the weak convergence theorem represents the asymmetry of the probability distribution. Furthermore, the weak limit measure heavily depends on the phase of the defect and initial state of the walker. Comparing with our previous studies, we also show some numerical results of the probability distribution to confirm that our result is relevant mathematically, and consider the effect of changing the phase and initial coin state on the probability distribution, or the ballistic spreading, which is one of the motivations of our study.
description: 24 pages, 12 figures. arXiv admin note: substantial text overlap with arXiv:1412.4309
Al-Qaṣīda al-Ḫazraǧiyya. Arabic Metrics Explained in Verses
Creators: name: Capezio, Oriana
Publisher: name: Fondazione Università Ca’ Foscari Venezia, Italia
Year: 2022

description:

Didactic poems are one of the main sources for the study of Arabic metrics; one of the best known and most widespread examples is that of al-Ḫazraǧī, Ḍiyāʾ al-Dīn Abū Muḥammad ʿAbd Allāh ibn ʿUṯmān al-Mālikī al-Andalusī. His work, entitled al-Rāmiza al-šāfiya fī ʿilmay al-ʿarūḍ wa-l-qāfiya, came to be known as al-Qaṣīda al-Ḫazraǧiyya. The current study focuses on the presentation, translation, and description of this qaṣīda, based on the commentary made by Muḥammad ibn Abī Bakr al-Damāmīnī (d. 827/1424) and entitled al-ʿUyūn al-ġāmiza ʿalā ḫabāyā al-rāmiza. The main objective is to offer an Italian version of the qaṣīda, and at the same time to show that the didactic poem is, even today, a convenient starting point for the study of ʿilm al-ʿarūḍ.

description: Annali di Ca’ Foscari. Serie orientale
Ettore Sottsass jr’s Archive
Creators: name: Bulegato, Fiorella
name: Scotti, Marco
Publisher: name: Fondazione Università Ca’ Foscari Venezia, Italia
Year: 2022

description:

Ettore Sottsass archive is a fragmented and dispersed reality. At present only an historical research, together with the application of digital strategies and digitisation practices, could (re)construct it as a complete and coherent network of projects. It is today housed in several different institutions: the funds recently donated to Fondazione Giorgio Cini are now central to an ongoing research study, promoted by IUAV University, Venice, together with the ARCHiVe Centre of the same foundation. The project is part of a multi-annual digitisation and inventorying work: its objective is to offer the access to unpublished primary sources to a wider audience.

description: magazén
Cse1l Is a Negative Regulator of CFTR-Dependent Fluid Secretion
Creators: name: Stainier, Didier Y.R.
name: Huisken, Jan
name: Navis, Adam
name: Brand-Arzamendi, Koroboshka
name: Curado, Silvia
name: Bagnat, Michel
name: Herbstreith, Sara
name: Gabriel, Sherif
name: Mostov, Keith
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Transport of chloride through the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) channel is a key step in regulating fluid secretion in vertebrates[1, 2]. Loss of CFTR function leads to cystic fibrosis (CF)[1, 3, 4], a disease that affects the lungs, pancreas, liver, intestine and vas deferens. Conversely, un-controlled activation of the channel leads to increased fluid secretion and plays a major role in several diseases and conditions including cholera[5, 6] and other secretory diarrheas [7] as well as Polycystic Kidney Disease (PKD)[8–10]. Understanding how CFTR activity is regulated in vivo has been limited by the lack of a genetic model. Here, we used a forward genetic approach in zebrafish to uncover CFTR regulators. We report the identification, isolation and characterization of a mutation in the zebrafish cse1l gene that leads to the sudden and dramatic expansion of the gut tube. We show that this phenotype results from a rapid accumulation of fluid due to the un-controlled activation of the CFTR channel. Analyses in zebrafish embryos and mammalian cells indicate that Cse1l is a negative regulator of CFTR-dependent fluid secretion. This work demonstrates the importance of fluid homeostasis in development and establishes the zebrafish as a much needed model system to study CFTR regulation in vivo.
Tension Management in the Kinetochore
Creators: name: Bloom, Kerry
name: Yeh, Elaine
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The kinetochore is the protein machine built at the centromere that integrates mechanical force and chemical energy from dynamic microtubules into directed chromosome motion. The kinetochore also provides a powerful signaling function that is able to alter the properties of the spindle checkpoint and initiate a signal transduction cascade that leads to inhibition of the anaphase promoting complex and cell cycle arrest. Together, the kinetochore accomplishes the feat of chromosome segregation with unparalleled accuracy. Errors in segregation lead to Down’s syndrome, the most frequent inherited birth defect, pregnancy loss, and cancer. Over a century after the discovery of the kinetochore, an architectural map comprising greater than 100 proteins is emerging. Understanding the architecture and physical biology of the key components provides new insights into how this fascinating machine moves genomes.
External Validation of Equations that Use Demographic and Anthropometric Measurements to Predict Percent Body Fat
Creators: name: Lewis, C.E.
name: Stevens, J.
name: Cai, J.
name: Czerwinski, S.A.
name: Choh, A.C.
name: Reynolds, K.R.
Publisher: name: Wiley-Blackwell
Year: 2018

description: Objective: Numerous equation to predict percent body fat using demographics and anthropometrics have been published but external validation of these equations is limited. The objective of this study was to validate published equations that use anthropometrics for prediction of percent body fat using external data. Methods: Data were from the Visceral Fat, Metabolic Rate, and Coronary Heart Disease Risk I (VIM I) Study and the Fels Longitudinal Study (Fels). VIM I was conducted in a subset of subjects from the CARDIA study and included black and white adults 28–40 years (n = 392). Fels consisted of white participants 8–88 years (n = 1,044). Percent body fat assessed by dual X-ray absorptiometry (DXA) in these two studies was compared to results calculated using 13 equations from Stevens et al. and nine other published equations. Results: In general, the Stevens equations performed better than equations from other studies. For example, equation “I“ in women in VIM I, Fels adults, and Fels youth, R2 estimates were 0.765, 0.757 and 0.789, respectively. In men the estimates were 0.702 in VIM I, 0.822 in Fels adults and 0.905 in Fels youth. None of the results from the nine published equations showed R2 this high in corresponding groups. Conclusions: Our results indicate that several of the Stevens equations have external validity superior to that of nine other published equations among varying age groups, genders and races.
Holographic Cosmology from BIonic Solutions
Creators: name: Sepehri, Alireza
name: Faizal, Mir
name: Setare, Mohammad Reza
name: Ali, Ahmed Farag
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this paper, we will use a BIonic solution for analyzing the holographic cosmology. A BIonic solution is a configuration of a D3-brane and an anti-D3-brane connected by a wormhole, and holographic cosmology is a recent proposal to explain cosmic expansion by using the holographic principle. In our model, a BIonic configuration will be produced by the transition of fundamental black strings. The formation of a BIonic configuration will cause inflation. As the D3-brane moves away from the anti-D3-brane, The wormhole will get annihilated, and the inflation will end with the annihilation of this wormhole. However, it is possible for a D3-brane to collide with an anti-D3-brane. Such a collision will occur if the distance between the D3-brane and the anti-D3-brane reduces, and this will create tachyonic states. We will demonstrate that these tachyonic states will lead to the formation of a new wormhole, and this will cause acceleration of the universe before such a collision.
description: 16 pages, no figures, Accepted for Publication in IJMPA
Integrierte Netzplanung für Strom, Gas und Wärme : Konzepte für regionalisierte Szenarien und Netzentwicklung
Creators: name: Vorwerk, Daniela
name: Schulz, Detlef
name: Heise, Johannes
name: Mostafa, Marwan
name: Becker, Christian
name: Vieth, Jonathan
name: Sanina, Natalia
Publisher: name: Helmut-Schmidt-Universität/Universität der Bundeswehr Hamburg, Fakultät für Elektrotechnik, Professur für Elektrische Energiesysteme
Year: 2022
Subjects: subject: 620 Ingenieurwissenschaften
classificationCode: 600
subject: Technik
classificationCode: 620
subject: Ingenieurwissenschaften

description: Die integrierte Netzentwicklungsplanung beschreibt den Prozess für eine gemeinsame strategische Infrastrukturplanung für die leitungsgebundenen Energieträger Strom, Gas und Fern-/bzw. Nahwärme. Im Projekt iNeP wird dafür am Beispiel der Industriemetropole Hamburg eine Methodik entwickelt, die eine solche abgestimmte Netzplanung erlaubt. Dabei hat die Erfüllung des Hamburger Klimaplans höchste Priorität. Als ein zentraler erster Schritt der integrierten Netzplanung dient die Erstellung eines Szenariorahmens, in dem künftige Bedarfe sinnvoll abgeschätzt und darauf aufbauende geeignete Energiekonzepte entwickelt werden. Für die Regionalisierung von Bedarfen können entweder geeignete Top-Down Ansätze verwendet werden, oder auf Basis spezifischer für Hamburg verfügbarer regionaler Daten und gezielter Marktabfragen Prognosen auf detaillierterer räumlicher Ebene getroffen werden. Dazu wird der Ansatz „Neutraler Zonen “vorgestellt. Die als Energiemenge prognostizierten Bedarfe müssen zur Beurteilung der Netzkapazitäten in geeigneter Weise in zu liefernde Leistungen aus den Energienetzen übertragen werden. Hier wird auch die Berücksichtigung von Flexibilität in die Netzplanung thematisiert. Auf dem Szenariorahmen aufbauend geschieht die eigentliche Netzentwicklung. Dazu wird ein Programm zur Erstellung eines Netzmodells aus öffentlichen Daten sowie der Ansatz der Graphentheorie für Multi-Energie-Netze präsentiert.
description: ...
Probing anomalous Higgs couplings in $H \to Z V$ decays
Creators: name: Modak, Tanmoy
name: Srivastava, Rahul
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We analyze the possibility of probing anomalous Higgs couplings in the rare decays $H \to Z V$, $V$ being a vector quarkonium state. These rare decays involve both gauge as well as the Yukawa sectors and either of them can potentially be anomalous. We show that the branching fractions for $H \to Z V$ decays in Standard Model are small, making it a sensitive probe for anomalous Higgs couplings originating from physics beyond Standard Model. Moreover, as both $V$ and $Z$ can decay into pair of charged leptons, they provide experimentally clean channels and future LHC runs should observe such decays. We perform a model independent analysis and show how angular asymmetries can be used to probe these anomalous Higgs couplings, taking further decays of $V$ and $Z$ to pair of charged leptons into account. The angular asymmetries can provide significant information about anomalous Higgs couplings in both gauge and Yukawa sectors.
description: 16 pages, 8 Figures, 2 Tables, discussions and Refs. added