cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Monitoring Techniques based on Wearable Inertial Platforms for Patients Affected by Central Nervous System Diseases
Creators: name: LOCATELLI, Patrick
Publisher: name: Universit� degli studi di Bergamo
Year: 2019

description: Central nervous system (CNS) diseases are a broad category of neurological disorders affecting the structure or the functionality of the brain or spinal cord. Multiple sclerosis (MS), Parkinson's disease (PD), and essential tremor are only some of the most common disorders causing the reduction of motor capabilities, yet their incidence and prevalence on the population are remarkable. Nowadays, CNS diseases represent one of the major public health challenges: to help with their management, it is important for doctors and people with these long-term conditions to understand how their disease changes over time. To this purpose, several assessment tests are used by clinicians to diagnose and monitor the disorders: however, although such tests are typically administered and performed in supervised environments (such as hospitals), most of the symptoms and episodes happen outside of the healthcare structures.
The last decade has seen an increasing diffusion of wireless inertial platforms, and with them an explosion in the capability of monitoring individuals via sensors integrated in smartphones and wearable devices for medical and rehabilitation purposes in the healthcare field. Wearable technologies are typically used in two contexts. In a supervised context, subjects are followed by trained personnel while performing the required tests: by knowing a priori the test conditions and the surrounding environment, it is possible to exploit the wearable devices to extract many useful and disease-specific information. On the contrary, in an unsupervised context (such as home), subjects can be monitored while performing their everyday activities, increasing the probability of bumping into a scenario not replicable in clinic, for which the disease clearly shows itself: due the lack of prior knowledge, only general information about the subject activity can be actually inferred. For these reasons, accurate methods for retrieving information from data need to be designed on the basis of the specific monitored disease and usage context. In addition, other than the definition of the analysis algorithms, the wearable-based systems need to meet specific requirements in order for them to be used as long-term, research-grade monitoring tools.
This thesis presents simple, wearable-based methods and algorithms oriented towards the monitoring of patients affected by CNS disorders. Applications range from the detailed analysis of particular diseases performed in supervised environments (e.g. hospital and clinics), to a more general evaluation of the physical performances, potentially adaptable to several movement disorders. Several analysis algorithms as well as a dedicated wearable platform were specifically designed to cover the entire range of the above mentioned use cases, in order to provide medical staff with objective and simple-to-use monitoring tools.
Additional file 3 of APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward Aβ, through P2RY12
Creators: name: Sepulveda, Jordy
name: Kim, Jennifer Yejean
name: Binder, Joseph
name: Vicini, Stefano
name: Rebeck, G. William
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health

description: Additional file 3: Figure S3. A. Representative images of microglia in the entorhinal cortex (EC) and hippocampus (CA1) from 12- and 21-month-old APOE3 (E3) and APOE4 (E4) mice. Scale bar 20 µm. B. High magnification images of microglia in the entorhinal cortex (EC) and hippocampus (CA1) from 12- and 21-month-old APOE3 (E3) and APOE4 (E4) mice. Scale bar 20 µm. C. Binary overlaps of 12- and 21-months old APOE3 and APOE4 microglia in the EC and CA1. Scale bar 10 µm. D. Quantification of process velocity in response to 1 mM ATP across brain region in 12- months old mice. unpaired two-tailed Student’s t test. E. Quantification of process velocity in response to 1 mM ATP across brain region in 21- months old mice. Unpaired two-tailed Student’s t test.
RICERCHE SULL'AVVOCATURA E SUGLI ORDINI PROFESSIONALI IN AREA SUBALPINA NEI SECOLI XIX-XX
Creators: name: ABENA, ALICE
Publisher: name: Universit� degli Studi di Milano
Year: 2011

description: The idea to carry out a research on the history of professional associations, specifically on legal bar,
originates from a research project presented some years ago by Consiglio Nazionale Forense
(General Council of Lawyers of Italy) ? assisted by lawyers and lecturers ? who expressed their
ambition to develop an historical overview on the origins and development of legal bar in Italy.
The present work is not intended to carry out a detailed historical survey on each and every
Piedmontese professional association. It is the object of the present research to describe the role of a
lawyer in the 19th century society, to understand the way the profession changes constantly, the
way legal bar is arranged and how it interacts with the surrounding political and social environment.
Focusing on North Piedmont, the research on the documentation preserved at Courts produced
completely different results according to the place in point. Certainly, most of the documentation is
preserved in Turin, where trial records of the Consiglio dell?Ordine (General Council of the
Lawyers) since the first meeting after the legislative decree in 1874 were found: such material is in
good preservation status, probably because Turin professional association has always taken special
care of such documentation. As far as Ivrea is concerned instead, differently from Turin ? where
papers are found in volumes ? there is not an inventory and the documentation mainly consists of
scattered papers, which allowed to reconstruct the activities of the association and the relationships
between lawyers during the time in point. The analysis of these papers allowed to draw a picture of
some lawyers, to understand legal bar and their relationships with colleagues, authorities and
judiciary. In Biella and Novara no evidence of the association could be found. Thus, surveys on
single professionals were carried out based on private inventories (Fondo Pampuri in Novara and
Fondo Versano in Biella).
In conclusion, not only should the present work be considered from an historical point of view, but
also with reference to the current debate on the future of legal bar in the 21st century, taking into
account that the knowledge of past lawyers can be an important step forward to understand (and
discover) the identity of the contemporary lawyer.
In vivo evolution of Lactobacillus rhamnosus results in prolonged persistence in the digestive tract
Creators: name: Mark, Alexander Louis
Publisher: name: No Publisher Supplied
Year: 2024

description: Lactobacillus rhamnosus, is a renowned probiotic organism found in many food supplements. This thesis research explored in-vivo evolution as a method to generate bacterial strains with longer bioavailability in the intestinal tract. Lactobacillus rhamnosus was autologously gavaged to mice multiple times to form two evolutionary variants of the bacteria after repeated passage through the intestinal tract. A significantly longer retention time (nearly 3x) and a slower elimination rate of the bacteria in the mouse gut was observed with each evolution. The evolutionary strains were further characterized for improved traits of gut retention such as bile salt resistance, epithelial cell binding, and genetic alterations to understand potential mechanistic hypotheses. Finally, a series of heterologous gavages were performed to determine if the increased retention of the evolutionary variants were because of animal specific host adaptations. Similar results were seen following these gavages, with longer retention and slower elimination observed between the wild type and the evolutionary isolates. Based on these findings, in-vivo evolution shows promise as a technique to generate probiotic strains with improved traits for gut retention as compared to the wild type.
sj-pdf-1-eji-10.1177_20587392211026109 – Supplemental material for Identifying factors causing decline in physical functionality of geriatric population
Creators: name: Asim, Muhammad
name: Aftab, Muhammad
name: Bhatti, Sajjad Haider
name: Ahmad, Tanvir
name: Ali Shah, Syed Muhammad
name: Akram, Muhammad
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Medicine
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Aged Health Care
subject: Paediatrics
subject: Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: Respiratory Diseases
subject: Veterinary Medicine
subject: Cell Biology
subject: Biochemistry
subject: Biological Sciences not elsewhere classified

description: Supplemental material, sj-pdf-1-eji-10.1177_20587392211026109 for Identifying factors causing decline in physical functionality of geriatric population by Muhammad Asim, Muhammad Aftab, Sajjad Haider Bhatti, Tanvir Ahmad, Syed Muhammad Ali Shah and Muhammad Akram in European Journal of Inflammation
sj-pdf-1-jir-10.1177_00221856211021885 - Supplemental material for Analysing the employment impact of Sunday wage premiums reductions: Implications for minimum wage research
Creators: name: Markey, Raymond
name: O’Brien, Martin
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business

description: Supplemental material, sj-pdf-1-jir-10.1177_00221856211021885 for Analysing the employment impact of Sunday wage premiums reductions: Implications for minimum wage research by Raymond Markey and Martin O’Brien in Journal of Industrial Relations
Supplemental Material, sj-docx-5-top-10.1177_00986283211024262 - Multi-Tiered System of Supports: An Ecological Approach to School Psychology Service Delivery
Creators: name: Loftus-Rattan, Susan M.
name: Wrightington, Mahri
name: Furey, Jenlyn
name: Case, Jessica
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Education
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental Material, sj-docx-5-top-10.1177_00986283211024262 for Multi-Tiered System of Supports: An Ecological Approach to School Psychology Service Delivery by Susan M. Loftus-Rattan, Mahri Wrightington, Jenlyn Furey and Jessica Case in Teaching of Psychology
sj-pdf-1-vas-10.1177_17085381211025168 – Supplemental Material for A comparison of endovascular versus open repair for ruptured abdominal aortic aneurysm – Meta-analysis of propensity score-matched data
Creators: name: Alsusa, Hatim
name: Shahid, Abbas
name: Antoniou, George A
Publisher: name: SAGE Journals
Year: 2021
Subjects: Cardiology

description: Supplemental Material, sj-pdf-1-vas-10.1177_17085381211025168 for A comparison of endovascular versus open repair for ruptured abdominal aortic aneurysm – Meta-analysis of propensity score-matched data by Hatim Alsusa, Abbas Shahid and George A Antoniou in Vascular
sj-pdf-1-aop-10.1177_10600280211025792 – Supplemental material for Efficacy of Metformin in Patients With Breast Cancer Receiving Chemotherapy or Endocrine Therapy: Systematic Review and Meta-analysis
Creators: name: Morio, Kayoko
name: Kurata, Yasuko
name: Kawaguchi-Sakita, Nobuko
name: Shiroshita, Akihiro
name: Kataoka, Yuki
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-1-aop-10.1177_10600280211025792 for Efficacy of Metformin in Patients With Breast Cancer Receiving Chemotherapy or Endocrine Therapy: Systematic Review and Meta-analysis by Kayoko Morio, Yasuko Kurata, Nobuko Kawaguchi-Sakita, Akihiro Shiroshita and Yuki Kataoka in Annals of Pharmacotherapy
Dad's evacuation
Creators: name: Project Team, Their Finest Hour
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Frederick was just eight years old when he was evacuated from Liverpool to Aberaeron in Wales. He boarded a train from Lime Street station as his mother waved him off along with hundreds of children. He said he loved it. It was the best time of his childhood, leaving behind a city for the countryside, and he was lucky enough to be with a good family. His mother would travel up from Liverpool and walk across the fields in her high-heeled shoes to get to see him but he wasn't homesick at all and was safe from the bombing in the city. He later travelled back to visit the town as an adult as it had such an impact on him.
Additional file 1 of A multiscalar methodology for holistic analysis of prehistoric rock carvings in Scotland
Creators: name: Barnett, Tertia
name: Valdez-Tullett, Joana
name: Bjerketvedt, Linda Marie
name: Alexander-Reid, Frederick
name: Hoole, Maya
name: Jeffrey, Stuart
name: Robin, Guillaume
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 1: Additional methods.
Synthesis of quinolizisine and benzoazole derivatives with potential pharmacological activity
Creators: name: SADEGHI, MOHAMMADREZA
Publisher: name: Universit� degli studi di Genova
Year: 2018

description: The aim of my thesis is twofold: the first research line consists in the synthesis of quinolizidine derivatives endowed with antiparasitic and anticholinesterase activity; the second study concerns the design and synthesis of benzotriazole derivatives with antitumor activity.
I focused my attention on quinolizidine alkaloids, particularly lupinine and cytisine, for the preparation of compounds endowed with potential therapeutic interest, and particularly antiparasitic against Leishmania tropica and Leishmania infantum, and anticholinesterase activity; the quinolizidine nucleus, indeed, is a chemical moiety that has been widely used to synthesize new molecules (as described in literature), due to its well known biological activities; quinolizidine alkaloids are also very suitable for the linkage to other chemical moiety, such as carbo- and heterocyclic systems.
I synthesized new N-alkyl and N-alkylarylcytisine derivatives, new basic molecules and some corresponding quaternary ammonium salts.
All these compounds showed a weak antiparasitic activity but a very good anticholinesterasic and antibutyrrilcholinesterasic activities. I also synthesized new lupinine, aminolupinane and thiolupinine derivatives of xanthene-9-carboxylic acid and new cytisine derivatives of 1,4-naphthoquinone and anthraquinone.
In parallel with this research line, I also developed an interest towards benzotriazolic derivatives: the benzotriazole nucleus is largely explored due to its broad spectrum of biological activities including antiviral, antimicrobial and anticancer properties. In addition, in our laboratory we recently synthesized benzotriazole-3,4,5-trimethoxybenzoate esters endowed with interesting antiproliferative activity (IC50 submicromolar). On this basis I synthesized two small series of 1-substituted benzoylbenzotriazoles (eight compounds) and of benzoic esters of 1-(2,3-hydroxyalkyl) benzotriazoles (28 compounds). Moreover, I also focused on another alkaloid, colchicine, well known for its antimitotic activity and its antitumoral potential (not yet exploited because of its disadvantages in therapy
such as a very high toxicity). I synthesized a series of eight novel colchicine derivatives characterized by substituted 1,2,3-benzotriazoles moieties. Since colchicine exerts its activity by binding to a site localized in ?-tubulin and thus achieving a conformational change in the tubulin dimer, I carried out docking simulations on the synthesized compounds, in order to predict their linkage to the ?-tubulin. In comparison with the x-ray structure of colchicine bound to tubulin, the new synthesized compounds showed a different orientation in the binding sites but the calculated Ki values appeared to be in the nanomolar or subnanomolar concentration range, and one of them in particular was endowed with a lower Ki value than colchicine.
Goodness of Fit Test For Wrapped Normal Distribution
Creators: name: Nodehi, Anahita
Publisher: name: Universit� degli studi di Bergamo
Year: 2019

description: One of the main difficulties in any statistical method is whether the data could have actually been drawn from that fitted distribution or not. To extend in circular data, it is necessary to consider nature feature of this data. The Wrapped Normal and Von Mises are two most important and famous distributions in circular. Based on the auther?s knowledge, there is no Goodness-of-Fit test for Wrapped Normal. To enhance this issue, in this paper, we present an appropriate test and compare its performance based on simulation study.
The Webber Family's Wartime Stories
Creators: name: Project Team, Their Finest Hour
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Great Grandma Betty Webber used to write poetry to Winston Churchill and actually received a handwritten letter in return, as well as one from his secretary.She was born in 1917 and her poems have been printed in books. Betty was interviewed on the radio about her poems. She often wrote about God, despite not believing in him, but she did it because she thought it would be what most people wanted to read. Francis Gordon Webber received medals in the war. His wife died and he was not excused from the war effort, so the child was put up for adoption. When he was finally given leave, it was too late. In 1937, he was the band master (see photo of man with a trumpet)One member of the family had a gas mask, which actually contained asbestos.
Francis made a photo frame using part of an aeroplane (see frame alongside photo of Francis with trumpet)Lukas' great grandfather owned a barber shop, where he also sold silk cigarette cards.
Chromosomal instability in enterohaemorrhagic Escherichia coli O157:H7: impact on adherence, tellurite resistance and colony phenotype.
Creators: name: Bielaszewska, Martina
name: Middendorf, Barbara
name: Tarr, Phillip I.
name: Zhang, Wenlan
name: Prager, Rita
name: Aldick, Thomas
name: Dobrindt, Ulrich
name: Karch, Helge
name: Mellmann, Alexander
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2011
Subjects: subject: Humans
subject: Virulence
subject: Sequence Deletion
subject: Phenotype
subject: DNA Bacterial/genetics
subject: Sequence Analysis DNA
subject: Cell Line Tumor
subject: Bacterial Adhesion/genetics
subject: Chromosomal Instability
subject: Escherichia coli O157/drug effects
subject: Escherichia coli O157/genetics
subject: Escherichia coli O157/pathogenicity
subject: Genomic Islands
subject: Multigene Family
subject: Tellurium/pharmacology
subject: 610 Medizin

description: Tellurite (Tel) resistant enterohaemorrhagic Escherichia coli (EHEC) O157:H7 is a global pathogen. In strain EDL933 Tel resistance (Tel(R) ) is encoded by duplicate ter cluster in O islands (OI) 43 and 48, which also harbour iha, encoding the adhesin and siderophore receptor Iha. We identified five EHEC O157:H7 strains that differentiate into large (L) colonies and small (S) colonies with high and low Tel minimal inhibitory concentrations (MICs) respectively. S colonies (Tel-MICs ≤ 4 µg ml⁻¹) sustained large internal deletions within the Tel(R) OIs via homologous recombination between IS elements and lost ter and iha. Moreover, complete excision of the islands occurred by site-specific recombination between flanking direct repeats. Complete excision of OI 43 and OI 48 occurred in 1.81 × 10⁻³ and 1.97 × 10⁻⁴ cells in culture, respectively; internal deletion of OI 48 was more frequent (9.7 × 10⁻¹ cells). Under iron limitation that promotes iha transcription, iha-negative derivatives adhered less well to human intestinal epithelial cells and grew slower than did their iha-positive counterparts. Experiments utilizing iha deletion and complementation mutants identified Iha as the major factor responsible for these phenotypic differences. Spontaneous deletions affecting Tel(R) OIs contribute to EHEC O157 genome plasticity and might impair virulence and/or fitness.
sj-pdf-1-eau-10.1177_09562478211019836 – Supplemental material for A city on the edge: the political ecology of urban green space
Creators: name: Cobbinah, Patrick Brandful
name: Nyame, Valentina
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Economics
subject: 120599 Urban and Regional Planning not elsewhere classified
subject: FOS: Social and economic geography

description: Supplemental material, sj-pdf-1-eau-10.1177_09562478211019836 for A city on the edge: the political ecology of urban green space by Patrick Brandful Cobbinah and Valentina Nyame in Environment & Urbanization
Clusters of infectious diseases in German nursing homes – observations from a prospective infection surveillance study, October 2008 to August 2009
Creators: name: Schulz, Mathias
name: Mielke, Martin
name: Wischnewski, Nicoletta
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2011
Subjects: subject: Adult
subject: Humans
subject: Female
subject: Gastroenteritis/epidemiology
subject: Germany/epidemiology
subject: Cluster Analysis
subject: Male
subject: Middle Aged
subject: Population Surveillance
subject: Aged
subject: Respiratory Tract Infections/epidemiology
subject: Communicable Diseases/epidemiology
subject: Cross Infection/epidemiology
subject: Cross Infection/transmission
subject: Comorbidity
subject: Prospective Studies
subject: Aged 80 and over
subject: Disease Susceptibility
subject: Communicable Diseases/nursing
subject: Communicable Diseases/transmission
subject: Cross Infection/nursing
subject: Nursing Homes/statistics & numerical data
subject: Nursing Records
subject: Urinary Tract Infections/epidemiology
subject: Urinary Tract Infections/transmission
subject: 610 Medizin

description: A prospective infection surveillance study was carried out among residents of seven nursing homes in and around Berlin, Germany, from October 2008 to August 2009. A considerable number of infections were found to occur in clusters. Active surveillance was carried out using pre-established case definitions of infections in nursing homes (McGeer criteria). Case finding was based on routine nursing files. Infection rates were calculated per 1,000 resident days. Clusters were identified using a pre-established definition. In total 511 residents were observed during 74,626 resident days (rd), and 393 infections occurred in 243 participants, giving an overall incidence of infection of 5.3 per 1,000 rd. The most common infections were gastrointestinal infections (n=122; 1.6/1,000 rd), acute respiratory disease (n=86; 1.2/1,000 rd) and urinary tract infections (n=71; 1.0/1,000 rd). Seven clusters involving 74 infections in 57 residents were observed: three of acute respiratory disease, three of acute gastrointestinal disease and one of conjunctivitis. Attack rates varied between 11% and 61%. Clusters occurred frequently in the observed nursing homes and could be detected by infection surveillance based on routine documentation.
Inverse Problems in data-driven multi-scale Systems Medicine: application to cancer physiology
Creators: name: SCUSSOLINI, MARA
Publisher: name: Universit� degli studi di Genova
Year: 2018

description: Systems Medicine is an interdisciplinary framework involving reciprocal feedback between clinical investigation and mathematical modeling/analysis. Its aim is to improve the understanding of complex diseases by integrating knowledge and data across multiple levels of biological organization. This Thesis focuses on three inverse problems, arising from three kinds of data and related to cancer physiology, at different scales: tissues, cells, molecules.
The general assumption of this piece of research is that cancer is associated toa path ological glucose consumption and, in fact, its functional behavior can be assessed by nuclear medicine experiments using [18F]-fluorodeoxyglucose (FDG) as a radioactive tracer mimicking the glucose properties. At tissue-scale, this Thesis considers the Positron Emission Tomography (PET) imaging technique, and deals with two distinct issues within compartmental analysis. First, this Thesis presents a compartmental approach, referred to as reference tissue model, for the estimation of FDG kinetics inside cancer tissues when the arterial blood input of the system is unknown. Then, this Thesis proposes an efficient and reliable method for recovering the compartmental kinetic parameters for each PET image pixel in the context of parametric imaging, exploiting information on the tissue physiology.
Standard models in compartmental analysis assume that phosphorylation and dephosphorylation of FDG occur in the same intracellular cytosolic volume. Advances in cell biochemistry have shown that the appropriate location of dephosphorylation is the endoplasmic reticulum (ER). Therefore, at cell-scale, this Thesis formalizes a biochemically-driven compartmental model accounting for the specific role played by the ER, and applies it to the analysis of in vitro experiments on FDG uptake by cancer cell cultures obtained with a LigandTracer (LT) device.
Finally, at molecule-scale, this Thesis provides a preliminary mathematical investigation of a chemical reaction network (CRN), represented by a huge Molecular Interaction Map (MIM), describing the biochemical interactions occurring between signaling proteins in specific pathways within a cancer cell. The main issue addressed in this case is the network parameterization problem, i.e. how to determine the reaction rate coefficients from protein concentration data.
Translational control in malignant pleural mesothelioma
Creators: name: OLIVETO, STEFANIA
Publisher: name: Universit� degli Studi del Piemonte Orientale Amedeo Avogadro
Year: 2016

description: Protein synthesis is a cellular process finely regulated during growth and development and its deregulation can lead to cell apoptosis or disease. Translational control is rate-limiting in cancer growth and translation initiation step is emerging as an attractive therapeutic target. eIF6 is an antiassociation factor that regulates the availability of active 80S. Its activation is driven by the RACK1/PKC? axis, in a mTORc1 independent manner. We previously described that eIF6 haploinsufficiency causes a striking survival in the E?-Myc mouse lymphoma model, with lifespans extendend up to 18 months. microRNAs have been shown to regulate a wide range of biological processes destabilizing messenger RNAs and by repressing the translation of these mRNAs. Involvement of microRNAs in repression of translation suggests that they might be associated with polysomes. Here we screen for 1) eIF6 expression in human cancers and 2) association of microRNAs with polysomes in Malignant Pleural Mesothelioma (MPM). We show that MPM tumors and a MPM cell line (REN cells) contain high levels of hyperphosphorylated eIF6. Enzastaurin is a PKC beta inhibitor used in clinical trials. We prove that Enzastaurin treatment decreases eIF6 phosphorylation rate, but not eIF6 protein stability. The growth of REN, in vivo, and metastasis are reduced by either Enzastaurin treatment or eIF6 shRNA. Molecular analysis reveals that eIF6 manipulation affects the metabolic status of malignant mesothelioma cells. Less glycolysis and less ATP content are evident in REN cells depleted for eIF6 or treated with Enzastaurin (Anti-Warburg effect). We propose that eIF6 is necessary for Malignant Mesothelioma growth, in vivo, and can be targeted by kinase inhibitors. Finally we found that the MPM miRNA signature was characterized also by differential miRNAs subcellular distribution. In particular, only some miRNAs were expressed in the polysomal pool with variability in miRNAs occupancy, indicating that some miRNAs can repress translation, while others cannot. Particularly, we evidenced that polysome-bound miRNAs present a correlation with the cell cycle pathway in REN cell, a MPM epithelioid cell line, suggesting that their polysomal localization could explain how these miRNAs may regulate cell cycle components translation.
Antiretrovirale Therapie der HIV-Infektion
Creators: name: Doerr, Hans W.
name: Brockmeyer, Norbert H.
name: Salzberger, Bernd
name: Marcus, Ulrich
name: Brodt, Hans Reinhard
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2001
Subjects: subject: HIV
subject: antiretrovirale Therapie
subject: Resistenztestung
subject: antiretroviral therapy
subject: resistance test
subject: 610 Medizin

description: Die antiretrovirale Therapie der HIV-Infektion hat sich in den letzten zwei Jahren aufgrund neuer Therapieoptionen und -strategien deutlich gewandelt. Die Empfehlungen zur antiretroviralen Therapie wurden daher in Abhängigkeit von klinischen, immunologischen und virologischen Parametern von einem deutsch-österreichischen Expertengremium überarbeitet. Eingebrachte Studienergebnisse betreffen insbesondere die Wertung der Kombinationstherapien von zwei nukleosidanalogen reverse Transkriptase-Inhibitoren (NRTI) in Kombination mit einem nichtnukleosidanalogen reverse Transkriptase-Inhibitor (NNRTI) oder einem Proteaseinhibitor und mit drei NRTI. Diese Kombinationen werden hinsichtlich ihrer therapeutischen Effektivität und ihres Nebenwirkungsprofils gewichtet. Für eine effektive Therapie sind eine Resistenztestung und eine Bestimmung von Plasmamedikamentenspiegeln bedeutsame Parameter, die für das Monitoring wichtig sind, sowie Faktoren, die einen Wechsel und eine Unterbrechung der Therapie indizieren, werden aufgezeigt.
description: Antiretroviral Therapy in HIV-Infections During the last two years, antiretroviral therapy of HIV infections has changed dramatically. Therefore a board of German and Austrian physicians experienced in antiretroviral research and HIV patient care revised the guidelines for antiretroviral therapy and treatment and have strongly been influenced by data from latest studies on clinical, immunological and viral parameters. These studies mainly investigated combination therapies such as two nucleoside reverse transcritase inhibitor (NRTI) with one protease inhibitor or one non-nucleoside reverse transcriptase inhibitor with three NRTI. These combination therapies are evaluated in regard to their therapeutic effectiveness and their side effects. Resistance testing and drug monitoring are most important during therapy. Parameters which necessitate a change in or interruption of therapy are discussed.
APPLICATION OF COMPUTATIONAL METHODS FOR THE IDENTIFICATION OF NEW DDX3X INHIBITORS
Creators: name: TRIVISANI, CLAUDIA IMMACOLATA
Publisher: name: Universit� degli Studi di Siena
Year: 2021

description: The search for new antiviral drugs for the treatment of clinical and emerging viruses is a delicate task. Drugs available today are developed to target a specific virus or viral strain, and only few prophylactics show a broad-spectrum activity that can be used to treat drug-resistant infections or in case of emergencies. Among the strategies that can be pursued to search for new antiviral drugs, there is the inhibition of a host protein involved in the viral replication cycle. The inhibition of DDX3X, a human ATP-dependent RNA helicase, allowed to discover the first broad-spectrum antiviral compound able to inhibit the replication of HIV resistant strains, HCV and of emerging viruses like West Nile Virus, Japanese Encephalitis Virus, Dengue Virus.
In this project, several computational strategies have been applied to improve the biodistribution and pharmacokinetic properties of this compound and a fluorescent inhibitor was designed to understand the mode of action of DDX3X inhibitors in DENV infected cells.
The selective inhibition of DDX3X can be pursued targeting a small pocket, peculiar to the human protein, called unique motif (UM). The study of the interactions established by the first active compound within UM, allowed to identify the amino acids responsible of its activity. Considering these findings, a small library of derivatives able to establish the fundamental interactions with the UM was designed. Moreover, a pharmacophore-based virtual screening procedure allowed to discover new compounds that will be biologically evaluated as new UM inhibitors.
PROTAC is instead a potent strategy to target protein degradation. A PROTAC molecule, that is constituted by two active moieties hold together by a linker, allow the selective ubiquitination and degradation of the protein of interest by the proteasome. In this contest, the application of computational procedures on known SOCS2 binders, allowed to establish a SAR that will be used to design novel derivatives that can be used both as inhibitors of the protein and as binders of the E3 ligase. A pharmacophore-based virtual screening performed on the Elongin C allowed to discover new compounds that will be biologically evaluated to establish if they can be used as E3 ligase binders.
Supplemental Material, sj-pdf-1-dos-10.1177_15593258211024393 - Celecoxib Alleviates Radiation-Induced Brain Injury in Rats by Maintaining the Integrity of Blood-Brain Barrier
Creators: name: Xu, Xiaoting
name: Huang, Hao
name: Tu, Yu
name: Sun, Jiaxing
name: Xiong, Yaozu
name: Ma, Chenying
name: Qin, Songbing
name: Hu, Wentao
name: Zhou, Juying
Publisher: name: SAGE Journals
Year: 2021
Subjects: Pharmacology and Pharmaceutical Sciences not elsewhere classified
Radiology and Organ Imaging

description: Supplemental Material, sj-pdf-1-dos-10.1177_15593258211024393 for Celecoxib Alleviates Radiation-Induced Brain Injury in Rats by Maintaining the Integrity of Blood-Brain Barrier by Xiaoting Xu, Hao Huang, Yu Tu, Jiaxing Sun, Yaozu Xiong, Chenying Ma, Songbing Qin, Wentao Hu and Juying Zhou in Dose-Response
Progettare e innovare con le nanotecnologie : l'importanza della progettazione di nuovi prodotti nell'ambito nanotecnologico, modi e strumenti per sviluppare il processo innovativo
Creators: name: CASAROTTO, LUCA
Publisher: name: Universit� IUAV di Venezia
Year: 2012

description: Ogni innovazione tecnologica avvia dei processi di trasformazione che si sviluppano trasversalmente nel sistema tecnico, sociale, culturale ed economico che li circonda.
Anche l?innovazione dei prodotti � direttamente correlata a questo processo che permette la creazione di nuovi artefatti e lo sviluppo di nuove categorie di prodotti. Se il rapporto tecnologia/prodotti � un processo consolidato e universalmente riconosciuto, non lo � invece quello prodotti/tecnologia. L?innovazione di prodotto non avvia infatti dei processi di sviluppo tecnologico diretti ma, indirettamente, propone nuove problematiche e indirizzi di ricerca che possono riguardare anche la stessa innovazione tecnico-scientifica.
Con questa prospettiva � stato analizzato il tema delle nano applicazioni, un?innovazione tecnologica recente che non ha ancora trovato ampia applicazione nel panorama dei prodotti e che, dal punto di vista dello sviluppo tecnologico, � per lo pi� ancora in fase di ricerca.
L?obiettivo di questa tesi � quello di avvalorare l?importanza dei prodotti e della progettazione nei processi di innovazione (in particolare quella tecnico-scientifica) prendendo come ambito d?indagine le applicazioni nanotecnologiche. Dopo una prima parte teorica sui processi di innovazione, sono stati individuati gli strumenti pratici che meglio possono permettere uno sviluppo simultaneo dei due processi (tecnico-scientifico e di prodotti).
Nello specifico � stato individuato il database come lo strumento ottimale per mettere in relazione i due processi e le figure professionali che operano nei differenti ambiti. � quindi stato presentato una proposta di database che, sulla base delle propriet� delle applicazioni nanotecnologiche, riesca a mettere in relazione le differenti conoscenze, le scoperte e le proposte di ricercatori, gli ingegneri e i progettisti. Il risultato finale permette quindi di evidenziare come un progettista possa contribuire a produrre innovazione nel campo delle nanotecnologie.
Cross-aware Early Fusion with Stage-divided Vision and Language Transformer Encoders for Referring Image Segmentation
Creators: name: Cho, Yubin
name: Yu, Hyunwoo
name: Kang, Suk-ju
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Referring segmentation aims to segment a target object related to a natural language expression. Key challenges of this task are understanding the meaning of complex and ambiguous language expressions and determining the relevant regions in the image with multiple objects by referring to the expression. Recent models have focused on the early fusion with the language features at the intermediate stage of the vision encoder, but these approaches have a limitation that the language features cannot refer to the visual information. To address this issue, this paper proposes a novel architecture, Cross-aware early fusion with stage-divided Vision and Language Transformer encoders (CrossVLT), which allows both language and vision encoders to perform the early fusion for improving the ability of the cross-modal context modeling. Unlike previous methods, our method enables the vision and language features to refer to each other's information at each stage to mutually enhance the robustness of both encoders. Furthermore, unlike the conventional scheme that relies solely on the high-level features for the cross-modal alignment, we introduce a feature-based alignment scheme that enables the low-level to high-level features of the vision and language encoders to engage in the cross-modal alignment. By aligning the intermediate cross-modal features in all encoder stages, this scheme leads to effective cross-modal fusion. In this way, the proposed approach is simple but effective for referring image segmentation, and it outperforms the previous state-of-the-art methods on three public benchmarks.
description: Published in IEEE Transactions on Multimedia (TMM)
GABAergic synaptic protein dynamics measured by spectroscopic approaches.
Creators: name: COLACI, FRANCESCO
Publisher: name: Universit� degli studi di Genova
Year: 2018

description: The activity dependent adjustment of synaptic strength (synaptic plasticity) involves the reorganization of post-synaptic proteins. The fast diffusion of synaptic proteins has been shown to play an important role in such molecular rearrangements. Taking advantage of single particle tracking (SPT) and fluorescence recovery after photobleaching (FRAP) techniques, it has been demonstrated that during inhibitory long-term potentiation (iLTP) the scaffold protein gephyrin and GABAA receptors are accumulated and immobilized at post-synaptic inhibitory sites.
A Balancing Act Between Form And Function. How To Be A Successful Project Leader: Balancing Users', Architects' And Planners' Requirements In The Financial And Legal Context
Creators: name: Keßler, Ann- Barbara
Publisher: name: Zenodo
Year: 2018

description: Ann Kessler (Subproject Coordinator Campus WU)

How to be a successful project leader: balancing users', architects' and planners' requirements in the financial and legal context
The weight of APOBEC mutations in cancer development
Creators: name: TARANTINO, DANILO
Publisher: name: Universit� degli Studi di Siena
Year: 2021

description: AID/APOBEC protein family members share the common ability to deaminate cytosine into uracil and, by doing so, to mutate both RNA and DNA. In physiological conditions APOBECs activity against viruses, retroviruses, and mobile elements is carried on safely, thanks to cellular repair mechanisms that take care of possible self-inflicted DNA damage. The effects of their aberrant activity in cancer have been observed in the form of their mutational signature in the cancer genomes, in some cancers representing up to 90% of all genetic alterations. Yet, it is still to be defined their weight in driving tumorigenesis and tumor progression. It has been shown that APOBEC mutagenesis is driven by short bursts of expression rather than a stable overexpression, presumably because prolonged APOBECs activation might be cytotoxic. The hypothesis that drove my PhD work focuses on the possibility that APOBEC expression might represent a last-ditch effort to prevent cells to go through the final steps towards cellular transformation: as regulatory pathways and tumor suppressors fail to induce apoptosis, APOBEC induced DNA damages might not be counterbalanced by DNA repair pathways and genotoxic stress would eventually lead to cell death. I thus investigated the behavior of a human breast cancer cell-line (MCF-7) where the APOBEC3B gene was inactivated to assess its proliferation and colony forming capability, also after exogenous reconstitution of APOBEC3B. Intriguingly, doxycycline-mediated overexpression of APOBEC3B caused a small but significative decrease in both clonogenicity and proliferative capacity on the APOBEC3B-/- cells, while cells with the parent cell line no difference after APOBEC3B induction. Moreover, I assessed whether expression of known oncogenes -mutated forms of TP53, KRAS and CTNNB1- could affect APOBEC3B-/- cells: cells expressing endogenous APOBEC3B acquired a larger boost in proliferation compared to APOBEC3B-/- ones but only APOBEC3B-/- showed an increase in clonogenicity. This suggests that lack of APOBEC3B might indeed favor the onset of tumorigenic features. Altogether these results suggest that, during the very early stages of tumorigenesis, APOBEC3B-mutagenesis might play a different role compared to later stages, providing a new perspective on APOBECs as a potential ?tumor suppressor?.
Additional file 1 of Cell morphology best predicts tumorigenicity and metastasis in vivo across multiple TNBC cell lines of different metastatic potential
Creators: name: Conner, Sydney J.
name: Guarin, Justinne R.
name: Le, Thanh T.
name: Fatherree, Jackson P.
name: Kelley, Charlotte
name: Payne, Samantha L.
name: Parker, Savannah R.
name: Bloomer, Hanan
name: Zhang, Crystal
name: Salhany, Kenneth
name: McGinn, Rachel A.
name: Henrich, Emily
name: Yui, Anna
name: Srinivasan, Deepti
name: Borges, Hannah
name: Oudin, Madeleine J.
Publisher: name: figshare
Year: 2024
Subjects: Biophysics
Physical Sciences not elsewhere classified
Medicine
Cell Biology
Biotechnology
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Mathematical Sciences not elsewhere classified
Developmental Biology
Cancer

description: Additional file 1. Supplemental Material.
Approaches to shipboard power generation systems design and management. Probabilistic approach to load prediction and system optimal design, sizing and management
Creators: name: BOVERI, ALESSANDRO
Publisher: name: Universit� degli studi di Genova
Year: 2018

description: This doctoral thesis presents new ideas and formulations on shipboard power system sizing and management. The main motivation behind this work is to fill, at least in part, the current technological and mythological gap between land and marine applications, concerning the sizing and management of power systems. This gap is the result of several changes regarding both the electric and marine applications. Two of these are, for example, the recent increase of electric power installed on board modern vessels and recent development of technologies for land microgrids. In this context, it should be noted that, also the modern ships are comparable to land microgrids, where the generation and loads are close in space and the on board power system may work either islanded or connected to the land grid. Nowadays, microgrids are a hot topic in electric engineering, with a constant development of novel approaches for both their sizing and management. On the other hand, considering the increase in the power installed on board ships, the traditional methods developed in the last century to size and manage these systems have shown increasing limitations and inaccuracies. This results in oversized power generation systems, low performances and high level of air and sea pollution due to ships activities. To overcome these problems and criticalities, this work presents a probabilistic approach to load prediction, which may increase the flexibility of the power system design and allow a significant reduction in the total power installed. Moreover, the traditional method to size the diesel generators, based on satisfying the maximum load, it is revised with the formulation of an optimal problem, which can consider as input either the results of the traditional method to load prediction or those obtained applying the probabilistic one. Finally, due to the recent introduction in land microgrids of energy storage system, which may cover the power fluctuations due to renewable resources, allow a better management of energy and increase the quality of service, an optimum method is developed and described in order to select, size and manage these systems on board ships.
Supplemental Material, sj-docx-1-gsj-10.1177_21925682211022311 - Telemedicine in Spine Surgery: Global Perspectives and Practices
Creators: name: Riew, Grant J.
name: Lovecchio, Francis
name: Samartzis, Dino
name: Louie, Philip K.
name: Germscheid, Niccole
name: An, Howard
name: Cheung, Jason Pui Yin
name: Chutkan, Norman
name: Mallow, Gary Michael
name: Neva, Marko H.
name: Phillips, Frank M.
name: Sciubba, Daniel
name: El-Sharkawi, Mohammad
name: Valacco, Marcelo
name: McCarthy, Michael H.
name: Makhni, Melvin C.
name: Iyer, Sravisht
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 110314 Orthopaedics
subject: 110604 Sports Medicine
subject: FOS: Health sciences
subject: 110323 Surgery

description: Supplemental Material, sj-docx-1-gsj-10.1177_21925682211022311 for Telemedicine in Spine Surgery: Global Perspectives and Practices by Grant Riew, Francis Lovecchio, Dino Samartzis, Philip K. Louie, Niccole Germscheid, Howard An, Jason Pui Yin Cheung, Norman Chutkan, Gary Michael Mallow, Marko H. Neva, Frank M. Phillips, Daniel Sciubba, Mohammad El-Sharkawi, Marcelo Valacco, Michael H. McCarthy, Melvin Makhni and Sravisht Iyer in Global Spine Journal
Wideband cyclostationary spectrum sensing and characterization for cognitive radios
Creators: name: NAWAZ, TASSADAQ
Publisher: name: Universit� degli studi di Genova
Year: 2018

description: Motivated by the spectrum scarcity problem, Cognitive Radios (CRs) have been proposed as a solution to opportunistically communicate over unused spectrum licensed to Primary users (PUs). In this context, the unlicensed Secondary users (SUs) sense the spectrum to detect the presence or absence of PUs, and use the unoccupied bands without causing interference to PUs. CRs are equipped with capabilities such as, learning, adaptability, and recongurability, and are spectrum aware. Spectrum awareness comes from spectrum sensing, and it can be performed using different techniques.