cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Final Pilot Methodology - D10.5 INVADE H2020
Creators: name: Cordobes, Cristobal
name: Gjerløw, Per
Publisher: name: Zenodo
Year: 2019

description: This deliverable presents the final methodology used by each of the pilots. This final methodology is based on the references to KPIs included in deliverable D.10.2 and in the individual pilots’ obligations stated in the DoA. Each pilot bases their final methodology on this first period experiences, with specific adjustments, to fulfil these obligations. This description includes the final steps to be taken in the implementation process, to be prepared for the final tests, to achieve the expected results. This deliverable defines and describes all the processes for each pilot according to the implementation process and the deviations according to the individual DoA obligations. Apart from the General KPI’s, common for all pilots, each pilot will strive to prove their individual KPIs. This final methodology needs to be prepared and support these individual goals.
Existence and optimality conditions for relaxed mean-field stochastic control problems
Creators: name: Bahlali, Khaled
name: Mezerdi, Meriem
name: Mezerdi, Brahim
Publisher: name: arXiv
Year: 2017
Subjects: subject: Optimization and Control (math.OC)
subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 93E20, 60H30

description: We consider optimal control problems for systems governed by mean-field stochastic differential equations, where the control enters both the drift and the diffusion coefficient. We study the relaxed model, in which admissible controls are measure-valued processes and the relaxed state process is driven by an orthogonal martingale measure, whose covariance measure is the relaxed control. This is a natural extension of the original strict control problem, for which we prove the existence of an optimal control. Then, we derive optimality necessary conditions for this problem, in terms of two adjoint processes extending the known results to the case of relaxed controls.
description: 12 pages, To appear in Systems and Control Letters
Hop-by-Hop TCP for Sensor Networks
Creators: name: Lien, Yao-Nan
Publisher: name: figshare
Year: 2018
Subjects: subject: 100503 Computer Communications Networks
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Communication links in a sensor network are unstable such that running conventional TCP protocol over a high loss rate sensor networks will suffer from severe performance degradation. To handle a packet loss, conventional TCP retransmits the lost packet from its source. However, when error rate is high, it may have difficulty to deliver a packet to its destination. Considering that most applications on a sensor network prefer faster and reliable packet delivery to higher throughput, this paper proposes to use the Hop-byHop TCP protocol for sensor networks aiming to accelerate reliable packet delivery. Hop-by-Hop TCP makes every intermediate node in the transmission path execute a light-weight local TCP to guarantee the transmission of each packet on each link. It takes less time in average to deliver a packet in an error-prone environment. The performance of our approach is evaluated by simulation using NS-2 simulator. Our experiments show that Hop-by-Hop TCP outperforms TCP NewReno in both throughput and average packet delivery time. The fairness requirement is also achieved while Hop-by-Hop TCP coexists with other major TCP variants.
Hop-by-Hop TCP for Sensor Networks
Creators: name: Lindamen, Calvin
Publisher: name: figshare
Year: 2018
Subjects: subject: 100503 Computer Communications Networks
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Communication links in a sensor network are unstable such that running conventional TCP protocol over a high loss rate sensor networks will suffer from severe performance degradation. To handle a packet loss, conventional TCP retransmits the lost packet from its source. However, when error rate is high, it may have difficulty to deliver a packet to its destination. Considering that most applications on a sensor network prefer faster and reliable packet delivery to higher throughput, this paper proposes to use the Hop-byHop TCP protocol for sensor networks aiming to accelerate reliable packet delivery. Hop-by-Hop TCP makes every intermediate node in the transmission path execute a light-weight local TCP to guarantee the transmission of each packet on each link. It takes less time in average to deliver a packet in an error-prone environment. The performance of our approach is evaluated by simulation using NS-2 simulator. Our experiments show that Hop-by-Hop TCP outperforms TCP NewReno in both throughput and average packet delivery time. The fairness requirement is also achieved while Hop-by-Hop TCP coexists with other major TCP variants.
Additional file 7 of Whole-genome resequencing of wild and cultivated cannabis reveals the genetic structure and adaptive selection of important traits
Creators: name: Chen, Xuan
name: Guo, Hong-Yan
name: Zhang, Qing-Ying
name: Wang, Lu
name: Guo, Rong
name: Zhan, Yi-Xun
name: Lv, Pin
name: Xu, Yan-Ping
name: Guo, Meng-Bi
name: Zhang, Yuan
name: Zhang, Kun
name: Liu, Yan-Hu
name: Yang, Ming
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 7: Fig. S1. Analysis of the differences in the main phenotypic characteristics between wild cannabisand cultivated cannabis. The data represent the means ± SDs. Significant differences were determined using GraphPad Prism 8 software (* indicates P <0.05; ** indicates P < 0.01; *** indicates P < 0.001; **** indicates P< 0.0001).
Cyclodextrin metal-organic framework as vaccine adjuvants enhances immune responses
Creators: name: Li, Congcong
name: Chen, Chaoxi
name: Wei, Yucai
name: Tan, Min
name: Zhai, Shuo
name: Zhao, Juebo
name: Wang, Lu
name: Dai, Tao
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: It is urgently needed to develop novel adjuvants for improving the safety and efficacy of vaccines. Metal-organic frameworks (MOFs), with high surface area, play an important role in drug delivery. With perfect biocompatibility and green preparation process, the γ-cyclodextrin metal-organic framework (γ-CD-MOF) fabricated with cyclodextrin and potassium suitable for antigen delivery. In this study, we modified γ-CD-MOF with span-85 to fabricate the SP-γ-CD-MOF as animal vaccine adjuvants. The ovalbumin (OVA) as the model antigen was encapsulated into particles to investigate the immune response. SP-γ-CD-MOF displayed excellent biocompatibility in vitro and in vivo. After immunization, SP-γ-CD-MOF loaded with OVA could induce high antigen-specific IgG titers and cytokine secretion. Meanwhile, SP-γ-CD-MOF also significantly improved the proliferation of spleen cells and activated and matured the bone marrow dendritic cells (BMDCs). The study showed the potential of SP-γ-CD-MOF in vaccine adjuvants and provided a novel idea for the development of vaccine adjuvants.
title: ADCO, Cartulaire de Cîteaux pour les possessions de Tontenant (c. 1504), Cart. 184 (11 H 987), 105 folios, f. 0031
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2015
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire de Cîteaux pour les possessions de Tontenant (c. 1504), Archives départementales de la Côte-d'Or, Cart. 184 (11 H 987), 105 folios, f. 0031, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les possessions de Tontenant (c. 1504), Archives départementales de la Côte-d'Or, Cart. 184 (11 H 987), 105 folios, f. 0031, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Pediatric Anaphylaxis in the Prehospital Setting: Incidence, Characteristics, and Management
Creators: name: Andrew, Emily
name: Nehme, Ziad
name: Bernard, Stephen
name: Smith, Karen
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Objective: Although hospital presentations for pediatric anaphylaxis have been described in the literature, a minimal amount is known regarding the incidence, characteristics, and management of pediatric anaphylaxis presenting to emergency medical services (EMS). Methods: We performed a retrospective observational study of pediatrics (≤16 years) presenting to EMS in Victoria, Australia. Patients with suspected anaphylaxis were included if they were treated with epinephrine before or after EMS arrival. We used descriptive statistics to compare baseline characteristics and linear regression to assess trends in incidence over time. Results: Between July 2008 and June 2016, we identified 2,137 pediatric anaphylaxis presentations. Overall, 59% were male and 70% had pre-existing anaphylaxis. The age-adjusted incidence increased over the study period, from 11.8 presentations per 100,000 person-years in 2008–09 to 38.7 in 2015–16 (p for trend < 0.001). Common suspected allergens included nuts (52%) and dairy/milk formula (17%). In total, 1,333 (62%) patients received epinephrine via an autoinjector, and 51 (2%) from a doctor before EMS arrival. When compared to patients receiving epinephrine after EMS arrival, patients treated prior were more likely to present with vital signs within normal limits, including heart rate (66% vs. 84%, p < 0.001), systolic blood pressure (77% vs. 93%, p < 0.001) and respiratory rate (79% vs. 91%, p < 0.001). The most common EMS interventions were intramuscular epinephrine (45%) and inhaled salbutamol (14%). Three out-of-hospital cardiac arrests were observed, two of whom received endotracheal intubation. Conclusion: The incidence of prehospital pediatric anaphylaxis is increasing significantly. Despite this, most patients are hemodynamically stable on presentation and few require emergency treatments beyond the administration of intramuscular epinephrine.
Time-varying coupling functions: dynamical inference and cause of synchronization transitions
Creators: name: Stankovski, Tomislav
Publisher: name: arXiv
Year: 2017
Subjects: subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: Chaotic Dynamics (nlin.CD)
subject: Biological Physics (physics.bio-ph)
subject: Computational Physics (physics.comp-ph)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences

description: Interactions in nature can be described by their coupling strength, direction of coupling and coupling function. The coupling strength and directionality are relatively well understood and studied, at least for two interacting systems, however there can be a complexity in the interactions uniquely dependent on the coupling functions. Such a special case is studied here { synchronization transition occurs only due to the time-variability of the coupling functions, while the net coupling strength is constant throughout the observation time. To motivate the investigation, an example is used to present an analysis of cross-frequency coupling functions between delta and alpha brainwaves extracted from the electroencephalography (EEG) recording of a healthy human subject in a freerunning resting state. The results indicate that time-varying coupling functions are a reality for biological interactions. A model of phase oscillators is used to demonstrate and detect the synchronization transition caused by the varying coupling functions, during an invariant coupling strength. The ability to detect this phenomenon is discussed with the method of dynamical Bayesian inference, which was able to infer the time-varying coupling functions. The form of the coupling function acts as an additional dimension for the interactions and it should be taken into account when detecting biological or other interactions from data.
description: PRE, in press 2017
Hepatic stellate cell reprogramming via exosome-mediated CRISPR/dCas9-VP64 delivery
Creators: name: Luo, Nianan
name: Li, Jiangbin
name: Chen, Yafeng
name: Xu, Yan
name: Wei, Yu
name: Lu, Jianguo
name: Dong, Rui
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Hepatic stellate cells (HSCs) play a crucial role in the progression of liver fibrosis, which can be considered as the specific therapeutic target of anti-fibrotic treatment. Targeted induction of HSCs to hepatocytes via delivery of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (dCas9) system holds promise for hepatic fibrosis treatment. Our study here revealed that CRISPR/dCas9-VP64 system encapsulated in AML12 cell-derived exosomes could efficiently and successfully be delivered into the HSCs. In turn, the CRISPR/dCas9-VP64 system loaded in the exosomes can be efficiently released into the HSCs. As a proof-of-concept study, gRNA against hepatocyte nuclear factor 4α (HNF4α) together with the delivery of CRISPR/dCas9-VP64 system induced the HSCs to hepatocyte-like phenotype. In conclusion, our study here revealed that CRISPR/dCas9-VP64 system encapsulated in AML12 cell-derived exosomes could be functional in HSCs, emerging as a gene therapy strategy for hepatic fibrosis.
Muon g-2 in an Alternative Quasi-Yukawa Unification with Low Fine-Tuned Inverse SeeSaw Mechanism
Creators: name: Altin, Zafer
name: Ozdal, Ozer
name: Un, Cem Salih
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We explore the low scale implications of the Pati-Salam Model including the TeV scale right-handed neutrinos interacting and mixing with the MSSM fields through the inverse seesaw (IS) mechanism in the light of the muon anomalous magnetic moment (muon g-2) resolution, and highlight the solutions which are compatible with the Quasi-Yukawa Unification condition (QYU). We find that the presence of the right-handed neutrinos causes heavy smuons >~ 800 GeV in order to avoid tachyonic staus at the low scale. On the other hand, the sneutrinos can be as light as about 100 GeV along with the light charginos of mass
Dimethylsilanone generation from pyrolysis of polysiloxanes filled with nanosized silica and ceria/silica
Creators: name: Kulyk, Kostiantyn
name: Zettergren, Henning
name: Gatchell, Michael
name: Alexander, John D.
name: Borysenko, Mykola
name: Palianytsia, Borys
name: Larsson, Mats
name: Kulik, Tetiana
Publisher: name: arXiv
Year: 2016
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Polydimethylsiloxane (PDMS) is a widely used organosilicon polymer often employed in formulations with fine oxide particles for various high temperature applications. Although PDMS is considered to be thermally stable and chemically inert, it is not always clear how the oxide filler influences its thermoresistance, decomposition chemistry and what reactive products are formed in the underlying thermal reactions. In this work we use temperature programmed desorption mass spectrometry (TPD MS) to study the pyrolysis of PDMS and its composites with nanosized silica and ceria/silica. Our results suggest that the elusive organosilicon compound - dimethylsilanone is generated from PDMS over a broad temperature range (in some cases starting at 70$°$C). The presence of nano-oxides catalyzed this process. Ions characteristic of the fragmentation of dimethylsilanone under electron ionization were assigned with the aid of DFT structure calculations. Possible reaction mechanisms for generating dimethylsilanone were discussed in the context of the calculated kinetic parameters. Observed accompanying products of PDMS pyrolysis, such as tetramethylcyclodisiloxane and hexamethylcyclotrisiloxane, indicate that multiple channels are involved in the dimethylsilanone release.
description: 24 pages, 9 figures, 1 table
Persisting inter‐limb differences in patients following total hip arthroplasty four to five years after surgery? : a preliminary cross‐sectional study
Creators: name: John, Stefanie
name: Weizel, David
name: Heumann, Anna S.
name: Fischer, Anja
name: Orlowski, Katja
name: Mrkor, Kai-Uwe
name: Edelmann-Nusser, Jürgen
name: Witte, Kerstin
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: Gait
subject: Inter‐limb difference
subject: Muscle strength
subject: Range of motion
subject: Balance
subject: Total hip arthroplasty
subject: 790

description: Background: Total hip arthroplasty (THA) is an effective procedure for patients with end-stage hip osteoarthritis. However, whether or not pre-operatively existing functional deficits are persisting several years post-surgery in the affected limb has not been thoroughly researched. Therefore, the primary aim of this preliminary study was to include patients four to five years after undergoing THA and to investigate potential differences between the operated and non-operated leg in hip strength, range of motion (ROM), balance, and gait. The secondary aim was to compare these values from the operated leg of the patients to those of the legs of healthy subjects. Methods: Sixteen patients (age: 65.20 ± 5.32 years) following unilateral THA (post-operation time: 4.7 ± 0.7 years) and ten, healthy, age-matched control subjects (age: 60.85 ± 7.57 years) were examined for maximum isometric hip muscle strength, active ROM of the hip joint, balance and gait on both limbs. Paired t-tests were used to assess the inter-limb differences in the THA group. Analyses of covariance (ANCOVA) were performed to compare groups, using age as a covariate. Results: The analysis of inter-limb differences in patients following THA revealed significant deficits on the operated side for hip abduction strength (p = 0.02), for hip flexion ROM (p < 0.01) and for balance in terms of the length of center of pressure (COP) (p = 0.04). Compared to values of the control subjects, the patients demonstrated significantly reduced hip strength in flexion, extension and abduction (p < 0.05) on the operated leg as well as reduced ROM measures in hip flexion, extension and abduction (p < 0.05). Conclusions: The first results of this explorative study indicated that inter-limb differences as well as reduced hip strength and hip ROM compared with control subjects were still present four to five years after THA. These persisting asymmetries and deficits in patients following THA may be one explanation for the decrease in healthrelated quality of life (HRQoL) seen in patients over the years after surgery. Further studies are required to replicate these findings with a larger sample size.
title: Morphological regionalization for the urban renovation agenda  in Daegu, South Korea
Creators: name: Gohaud, Emilien
name: Schuetze, Thorsten
Publisher: name: Conference Proceedings  XXIX International Seminar on Urban Form ISUF 2022 Urban Redevelopment and Revitalisation A Multidisciplinary Perspective/ Lodz University of Technology Press
Year: 2023
Subjects: Morphological region, Numerical taxonomy, Urban renovation, Urban regeneration, Korea

description: Following the maturation of Korean cities, urban renovation has become the primary concern of urban policies. Large wholesale redevelopments continue to address decay from a purely physical point of view. In contrast, new area-based urban regeneration projects propose a more delicate and holistic approach to addressing urban decline. The designation of redevelopment or regeneration project areas is not based on the presence of specific urban forms but primarily on technical and economic prospects. As a result, the urban tissue is increasingly losing its structure and coherence. To better connect urban renovation with urban form, it is necessary to identify the various urban fabrics composing large cities such as Daegu. This research executed a large-scale morphological regionalization analysis for the central Daegu city area, based on analysing and evaluating mapping results based on two mapping methods: mixed morphogenetic mapping and morphogenetic mapping. The research results unveil that the urban renovation processes in Daegu lead to the overall consolidation of large apartment complex areas. In contrast, the fine grain urban fabrics that still cover the largest share of the urbanized area are increasingly fragmented. The proposed regionalization is the base for new urban renovation strategy propositions.
Torsional and rotational coupling in non-rigid molecules
Creators: name: Omiste, Juan J.
name: Madsen, Lars Bojer
Publisher: name: arXiv
Year: 2016
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We analyze theoretically the interplay between the torsional and the rotational motion of an aligned biphenyl-like molecule. To do so, we consider a transition between two electronic states with different internal torsional potentials, induced by means of a resonant laser pulse. The change in the internal torsional potential provokes the motion of the torsional wavepacket in the excited electronic state, modifying the structure of the molecule, and hence, its inertia tensor. We find that this process has a strong impact on the rotational wave function, displaying different behavior depending on the electronic states involved and their associated torsional potentials. We describe the dynamics of the system by considering the degree of alignment and the expectations values of the angular momentum operators for the overall rotation of the molecule.
description: 10 pages, 6 figures
Driving protocol for a Floquet topological phase without static counterpart
Creators: name: Quelle, A.
name: Weitenberg, C.
name: Sengstock, K.
name: Smith, C. Morais
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: Periodically driven systems play a prominent role in optical lattices. In these ultracold atomic systems, driving is used to create a variety of interesting behaviours, of which an important example is provided by topological states of matter. Such Floquet topological phases have a richer classification that their equilibrium counterparts. Although analogues of the equilibrium topological phases exist, which are characterised by a Chern number, the corresponding Hall conductivity, and protected edge states, there is an additional possibility. This is a phase that has vanishing Chern number and no Hall conductivity, but nevertheless hosts anomalous topological edge states. Due to experimental difficulties associated with the observation of such a phase, it has not been experimentally realised so far. In this paper, we show that optical lattices prove to be a good candidate for both its realisation and subsequent observation, because they can be driven in a controlled manner. Specifically, we present a simple shaking protocol that serves to realise this special Floquet phase, discuss the specific properties that it has, and propose a method to experimentally detect this fascinating topological phase that has no counterpart in equilibrium systems.
description: 14 pages, 4 figures
Formulation, characterization, and cellular toxicity assessment of tamoxifen-loaded silk fibroin nanoparticles in breast cancer
Creators: name: Moin, Afrasim
name: Wani, Shahid Ud Din
name: Osmani, Riyaz Ali
name: Abu Lila, Amr S.
name: Khafagy, El-Sayed
name: Arab, Hany H.
name: Gangadharappa, Hosahalli V.
name: Allam, Ahmed N.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Silk fibroin (SF) is a natural polymeric biomaterial that is widely adopted for the preparation of drug delivery systems. Herein, we aimed to fabricate and characterize SF nanoparticles loaded with the selective estrogen receptor modulator; tamoxifen citrate (TC-SF-NPs) and to assess their in vitro efficacy against breast cancer cell lines (MCF-7 and MDA-MB-231). TC-loaded SF-NPs were characterized for particle size, morphology, entrapment efficiency, and release profile. In addition, we examined the in vitro cytotoxicity of TC-SF-NPs against human breast cancer cell lines and evaluated the anticancer potential of TC-SF-NPs through apoptosis assay and cell cycle analysis. Drug-loaded SF-NPs showed an average particle size of 186.1 ± 5.9 nm and entrapment efficiency of 79.08%. Scanning electron microscopy (SEM) showed the nanoparticles had a spherical morphology with smooth surface. Tamoxifen release from SF-NPs exhibited a biphasic release profile with an initial burst release within the first 6 h and sustained release for 48 h. TC-SF-NPs exerted a dose-dependent cytotoxic effect against breast cancer cell lines. In addition, flow cytometry analysis revealed that cells accumulate in G0/G1 phase, with a concomitant reduction of S- and G2-M-phase cells upon treatment with TC-SF-NPs. Consequently, the potent anticancer activities of TC-SF-NPs against breast cancer cells were mainly attributed to the induction of apoptosis and cell cycle arrest. Our results indicate that SF nanoparticles may represent an attractive nontoxic nanocarrier for the delivery of anticancer drugs.
Modeling the Network Dynamics of Pulse-Coupled Neurons
Creators: name: Chandra, Sarthak
name: Hathcock, David
name: Crain, Kimberly
name: Antonsen, Thomas M.
name: Girvan, Michelle
name: Ott, Edward
Publisher: name: arXiv
Year: 2017
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: We derive a mean-field approximation for the macroscopic dynamics of large networks of pulse-coupled theta neurons in order to study the effects of different network degree distributions, as well as degree correlations (assortativity). Using the ansatz of Ott and Antonsen (Chaos, 19 (2008) 037113), we obtain a reduced system of ordinary differential equations describing the mean-field dynamics, with significantly lower dimensionality compared with the complete set of dynamical equations for the system. We find that, for sufficiently large networks and degrees, the dynamical behavior of the reduced system agrees well with that of the full network. This dimensional reduction allows for an efficient characterization of system phase transitions and attractors. For networks with tightly peaked degree distributions, the macroscopic behavior closely resembles that of fully connected networks previously studied by others. In contrast, networks with scale-free degree distributions exhibit different macroscopic dynamics due to the emergence of degree dependent behavior of different oscillators. For nonassortative networks (i.e., networks without degree correlations) we observe the presence of a synchronously firing phase that can be suppressed by the presence of either assortativity or disassortativity in the network. We show that the results derived here can be used to analyze the effects of network topology on macroscopic behavior in neuronal networks in a computationally efficient fashion.
description: 10 pages, 7 figures
Fractional div-curl quantities and applications to nonlocal geometric equations
Creators: name: Mazowiecka, Katarzyna
name: Schikorra, Armin
Publisher: name: arXiv
Year: 2017
Subjects: subject: Analysis of PDEs (math.AP)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 42B37, 42B30, 35R11, 58E20, 35B65

description: We investigate a fractional notion of gradient and divergence operator. We generalize the div-curl estimate by Coifman-Lions-Meyer-Semmes to fractional div-curl quantities, obtaining, in particular, a nonlocal version of Wente's lemma. We demonstrate how these quantities appear naturally in nonlocal geometric equations, which can be used to obtain a theory for fractional harmonic maps analogous to the local theory. Firstly, regarding fractional harmonic maps into spheres, we obtain a conservation law analogous to Shatah's conservation law and give a new regularity proof analogous to Hélein's for harmonic maps into spheres. Secondly, we prove regularity for solutions to critical systems with nonlocal antisymmetric potentials on the right-hand side. Since the half-harmonic map equation into general target manifolds has this form, as a corollary, we obtain a new proof of the regularity of half-harmonic maps into general target manifolds following closely Rivière's celebrated argument in the local case. Lastly, the fractional div-curl quantities provide also a new, simpler, proof for Hölder continuity of $W^{s,n/s}$-harmonic maps into spheres and we extend this to an argument for $W^{s,n/s}$-harmonic maps into homogeneous targets. This is an analogue of Strzelecki's and Toro-Wang's proof for $n$-harmonic maps into spheres and homogeneous target manifolds, respectively.
Beal's conjecture
Creators: name: Vega, Frank
Publisher: name: figshare
Year: 2018
Subjects: subject: 10101 Algebra and Number Theory
subject: FOS: Mathematics

description: We prove if $A^{x} + B^{y} = C^{z}$, where $A$, $B$, $C$, $x$, $y$ and $z$ are positive integers, $x$, $y$ and $z$ are all greater than $2$, then $A$, $B$ and $C$ must have a common prime factor. In this way, we demonstrate the Beal's conjecture using the properties of divisibility and applying the reductio ad absurdum.
Membrane protein-chimeric liposome-mediated delivery of triptolide for targeted hepatocellular carcinoma therapy
Creators: name: Zheng, Yanwen
name: Kong, Fanhua
name: Liu, Songyang
name: Liu, Xi
name: Pei, Dongni
name: Miao, Xiongying
Publisher: name: Taylor & Francis
Year: 2021
Subjects: Biophysics
Biochemistry
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Hematology
Virology

description: Triptolide (TPL) is a diterpenoid triepoxide with broad antitumor efficacy, while lack of mechanism of action, severe systemic toxicity, and poor water solubility of TPL limited its usage. To unveil the mechanism of action and improve the pharmaceutical properties of TPL, here we explored the molecular mechanism of TPL and then fabricated TPL-loaded membrane protein-chimeric liposomes (TPL@MP-LP) and tested its anticancer efficacy against hepatocellular carcinoma (HCC). CCK8 assay, colony formation assay, EdU assay, and flow cytometry were used to examine the activity of TPL. RNA sequence and gain-and-loss of function assays were used to explore the molecular mechanisms. TPL@MP-LP was characterized by size, zeta potential, polydispersity index, and transmission electron microscopy. Cellular uptake and cell viability assay were performed to evaluate the internalization and anticancer efficacy of TPL@MP-LP in vitro. Biodistribution and in vivo antitumor efficacy of TPL@MP-LP were evaluated on orthotopic HCC mice models. TPL robustly inhibited HCC cells by inducing cell proliferation arrest, apoptosis via the mitochondrial pathway, and necroptosis via RIPK1/RIPK3/MLKL signaling. TPL was successfully loaded into MP-LP, with a drug-loading capacity of 5.62 ± 0.80%. MP-LP facilitated TPL internalization and TPL@MP-LP exerted enhanced anticancer efficacy against Huh7 cells. TPL@MP-LP showed targeting ability to the tumor site. More importantly, TPL@MP-LP treatment suppressed tumor growth but showed minimal damage to liver and renal functions. TPL exerted anticancer effects on HCC via inducing cell proliferation arrest, apoptosis, and necroptosis, and the MP-LP might be a promising delivery strategy to improve the antitumor efficacy while mitigating toxicity of TPL for HCC therapy.
Cultures, practices and politics of cannabis consumption in 20th century colonial and dictatorial Spain (1920-1980)
Creators: name: Hill, Joshua Alexander
Publisher: name: The University of St Andrews
Year: 2024
Subjects: History
Spain
Drugs
Cannabis

description: This thesis explores the use of cannabis, and the politics that surrounded it, in Spain and Spanish Morocco between 1920 and 1980. It takes a cultural-constructivist approach to drugs, viewing them as culturally contingent, and therefore historical artefacts that can act as heuristic devices. Using cannabis in this way, it looks at how the same drug took on multiple guises in the 60 years that this thesis spans. It looks at how the effects of and narratives that surrounded cannabis changed over time, in ways that often reflected wider social changes, although in ways that were often unpredictable and surprising. In doing so it hopes to bring to light elements of Spanish culture and society that the historian might not otherwise encounter. It also hopes to similarly bring to light the ways in which Spaniards consumed cannabis, and the reasons for doing so. This provides a small glimpse into their inner worlds – drugs by nature elicit highly emotive responses. Above all, it hopes to historicise cannabis, by showing how, in different times and places, the same drug could take on multiple different guises.
Acceleration of diffusion in ethylammonium nitrate ionic liquid confined between parallel glass plates
Creators: name: Filippov, Andrei
name: Gnezdilov, Oleg I.
name: Hjalmarsson, Nicklas
name: Antzutkin, Oleg N.
name: Glavatskih, Sergei
name: Furó, Istvan
name: Rutland, Mark W.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: The bulk self diffusion of the ethylammonium cation and the nitrate anion can both be described by respective single diffusion coefficients. Diffusion of the anion is 1.7 times higher than that of the cation. This indicates no tight association of the ions in the ionic liquid. For the ethylammonium cation confined between glass plates the effective diffusion coefficient along, as well as normal to the confining glass plates is higher by a factor of 1.86 as compared to that in the bulk. The same time, NMR T2 relaxation of protons of NH3 group of the EA cation is faster by a factor of 22 than that in bulk. 2H NMR spectra of selectively labeled CH2 and CH3 groups of EA do not demonstrate any ordering of the EA between the glass plates. We suggested that these data favor a model where a bulk isotropic sponge like structure of EAN is saved in the confinement, but sizes of connecting channels increases. Those leads to faster translational diffusion and faster exchange processes of protons of NH3 group, in comparison with the bulk.
description: 11 pages, 5 figures, 1 table
title: Europe at the close of the tenth century
Creators: name: Larned, J. N. (Josephus Nelson)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2025

description: Extracted from "History for ready reference, from the best historians, biographers, and specialists; their own words in a complete system of history .."
description: Source: https://www.gutenberg.org/ebooks/66861
Input on user behaviour and technology domestication amongst users to the business model development - D9.2 INVADE H2020
Creators: name: Throndsen, William
name: Ryghaug, Marianne
Publisher: name: Zenodo
Year: 2018

description: This document provides the INVADE project with a review of studies on end users of smart energy technology and tariff models. The report provides a thorough review of state of the art literature and previous studies on the role of the end user in relation to energy use. The results cover both qualitative and quantitative analyses on end users and energy use. It also provides a short overview of theoretical perspectives of science and technology studies (STS) that are useful for understanding user engagement with energy markets, business models, tariff structures, and technology and the basis of many of the contributions in the review as well as our recommendations. The aim of the report is to provide INVADE knowledge and insight to the design and deployment of business models and smart energy technologies. It provides recommendations in four sections on 1) intervention and feedback, 2) introducing new technology, 3) segmentation and tariffs, and 4) vehicle to grid.
The Beal's Conjecture Answer
Creators: name: Vega, Frank
Publisher: name: figshare
Year: 2018
Subjects: subject: 10101 Algebra and Number Theory
subject: FOS: Mathematics

description: We prove if $A^{x} + B^{y} = C^{z}$, where $A$, $B$, $C$, $x$, $y$ and $z$ are positive integers, $x$, $y$ and $z$ are all greater than $2$, then $A$, $B$ and $C$ must have a common prime factor. In this way, we demonstrate the Beal's conjecture using the properties of congruence and applying the reductio ad absurdum.
Non-standard hierarchies of the runnings of the spectral index in inflation
Creators: name: Longden, Chris
Publisher: name: arXiv
Year: 2017
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Recent analyses of cosmic microwave background surveys have revealed hints that there may be a non-trivial running of the running of the spectral index. If future experiments were to confirm these hints, it would prove a powerful discriminator of inflationary models, ruling out simple single field models. We discuss how isocurvature perturbations in multi-field models can be invoked to generate large runnings in a non-standard hierarchy, and find that a minimal model capable of practically realising this would be a two-field model with a non-canonical kinetic structure. We also consider alternative scenarios such as variable speed of light models and canonical quantum gravity effects and their implications for runnings of the spectral index.
description: 10 pages, conference proceedings for VARCOSMOFUN'16, submitted to special issue "Varying Constants and Fundamental Cosmology" in Universe
Self-assembled polymeric nanocarrier-mediated co-delivery of metformin and doxorubicin for melanoma therapy
Creators: name: Song, Mingming
name: Xia, Wentao
name: Tao, Zixuan
name: Zhu, Bin
name: Zhang, Wenxiang
name: Liu, Chang
name: Chen, Siyu
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Malignant melanoma is a life-threatening form of skin cancer with a low response rate to single-agent chemotherapy. Although combined therapies of metformin (MET) and doxorubicin (DOX) are effective in treating a variety of cancers, including breast cancer, their different physicochemical properties and administration routines reduce the effective co-accumulation of both drugs in tumors. Nanoparticles (NPs) have been demonstrated to potentially improve drug delivery efficiency in cancer therapy of, for example, liver and lung cancers. Hence, in this study, we prepared pH-sensitive, biocompatible, tumor-targeting NPs based on the conjugation of biomaterials, including sodium alginate, cholesterol, and folic acid (FCA). As expected, since cholesterol and folic acid are two essentials, but insufficient, substrates for melanoma growth, we observed that the FCA NPs specifically and highly effectively accumulated in xenograft melanoma tumors. Taking advantage of the FCA NP system, we successfully co-delivered a combination of MET and DOX into melanoma tumors to trigger pyroptosis, apoptosis, and necroptosis (PANoptosis) of the melanoma cells, thus blocking melanoma progression. Combined, the establishment of such an FCA NP system provides a promising vector for effective drug delivery into melanoma and increases the possibility and efficiency of drug combinations for cancer treatment.
Electrostatic Correlations and the Polyelectrolyte Self Energy
Creators: name: Shen, Kevin
name: Wang, Zhen-Gang
Publisher: name: arXiv
Year: 2017
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We address the effects of chain connectivity on electrostatic fluctuations in polyelectrolyte solutions using a field-theoretic, renormalized Gaussian fluctuation (RGF) theory. As in simple electrolyte solutions (Z.-G. Wang, Phys. Rev. E. {\bf 81}, 021501 (2010)), the RGF provides a unified theory for electrostatic fluctuations, accounting for both dielectric and charge correlation effects in terms of the self-energy. Unlike simple ions, the polyelectrolyte self energy depends intimately on the chain conformation, and our theory naturally provides a self-consistent determination of the response of intramolecular chain structure to polyelectrolyte and salt concentrations. The theory captures the expected scaling behavior of chain size from the dilute to semi-dilute regimes; by properly accounting for chain structure the theory provides improved estimates of the self energy in dilute solution and correctly predicts the eventual $N$-independence of the critical temperature and concentration of salt-free solutions of flexible polyelectrolytes. We show that the self energy can be interpreted in terms of an infinite-dilution energy $μ^\text{el}_{m,0}$ and a finite concentration correlation correction $μ^\text{corr}$ which tends to cancel out the former with increasing concentration.
description: Submitted (JCP)
Report on legal policy implications - D9.3 INVADE H2020
Creators: name: de Brey, Baerte
Publisher: name: Zenodo
Year: 2018

description: In this report we identify institutional bottlenecks that impede the development of the Smart Charging of electric vehicles, as well as batteries in the distribution grid. Also, in the Norwegian, German, Bulgarian and Spanish locations there is a focus on batteries in household and grid. We subsequently identify possible solutions for the most important and urgent bottlenecks. In this way, both market and government are assisted with concrete ideas in order to accelerate the development of Smart Charging in the short term. The study also provides a starting point for the design of an efficiently and effectively functioning market.
Proton distributions in $dp$ dielectron production within Regge theory
Creators: name: Jerusalimov, A. P.
name: Lykasov, G. I.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The processes of dielectron production in deuteron-proton collisions at intermediate incident deuteron beam energies are analyzed in the spectator model within the one-pion exchange reggeized approach. We focus mainly on the momentum and angle distributions of the proton-spectator and the proton emitted in quasi-free $NN$ processes at small angles in the laboratory frame. It is shown that the inclusion of many channels in quasi-free $NN$ interaction allows us to describe the HADES data quite satisfactorily at incident deuteron kinetic energies of about 2.5 GeV.
description: 11 pages, 77 figures
Final Results from Pilots - D10.6 INVADE H2020
Creators: name: Gjerløw, Per
name: Thorbjørnsen, Trond
name: Stanev, Dimitar
name: Gallart, Ramon
Publisher: name: Zenodo
Year: 2019

description: Document D.10.6 reports the conclusions obtained during the pilots and the collected data analysis in T10.3-7. This deliverable gives an overview of all the results from each of the 5 pilots in a structured way. The reference for the results and the performance reported is based on key performance indicators (KPIs) that were defined in D10.2. These KPIs are based on expected improvements from using the INVADE concept/platform.
Nigerian land tenure and food security
Creators: name: Hendriks, Sheryl
name: Ibrahim, Hussian
Publisher: name: University of Pretoria
Year: 2022
Subjects: Other agricultural, veterinary and food sciences not elsewhere classified

description: Dataset are for a journal contribution on examining the association between land tenure and food security among 1434 sampled smallholders from the Nigeria Living Standards Measurement Study-Integrated Surveys on Agriculture (LSMS-ISA) three-round panel dataset.
Full Range of Motion vs Partial Range of Motion at Longer-Muscle Lengths: Effects on Upper-Body Muscle Morphology and Strength
Creators: name: Wolf, Milo
Publisher: name: OSF Registries
Year: 2024
Subjects: subject: Sports Studies
subject: Social and Behavioral Sciences
subject: Other Social and Behavioral Sciences

description: The purpose of this study will be to compare the effects of full range of motion and lengthened partials on muscle morphology and performance.

Funding for this study was provided by Jeff Nippard.
Gateway schemes of quantum control for spin networks
Creators: name: Maruyama, Koji
name: Burgarth, Daniel
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Towards the full-fledged quantum computing, what do we need? Obviously, the first thing we need is a (many-body) quantum system, which is reasonably isolated from its environment in order to reduce the unwanted effect of noise, and the second might be a good technique to fully control it. Although we would also need a well-designed quantum code for information processing for fault-tolerant computation, from a physical point of view, the primary requisites are a system and a full control for it. Designing and fabricating a controllable quantum system is a hard work in the first place, however, we shall focus on the subsequent steps that cannot be skipped and are highly nontrivial.
description: 32 pages, 5 figures, book chapter