cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Practical techniques for organizing and measuring knowledge.
Creators: name: Lethbridge, Timothy Christian.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Information Science.

description: This research is concerned with the problem of making knowledge acquisition and representation practical for a wide variety of people. The key question investigated is the following: What features are needed in what this research defines as a knowledge management system, so that people who are not computer specialists can use it for tasks that involve manipulating complex ideas? In this research the needs of such users were evaluated, and several prototype systems were created, culminating in the creation of a system called CODE4. A key conclusion is as follows: Users need a tool that involves the synthesis of several techniques for organizing the knowledge. The research has led to ideas for two types of features: abstract knowledge representation features and user interface features. Some of the proposed abstract knowledge representation features that are novel or improved include: (1) a uniform treatment of units of knowledge which are called concepts; (2) the separation of the names of concepts from their unique identities so that concepts can have multiple names and a given name can be used for several concepts; (3) the classification of conceptual relations using property and statement hierarchies, and (4) facilities for smoothly integrating informal knowledge with knowledge that is more precisely represented. The above ideas are implemented in CODE4-KR, the abstract knowledge representation used in the CODE4 knowledge management system. Some of the user interface features that are found in CODE4, and are proposed for general use, are: (1) unlimited chained browsers; (2) knowledge maps, representing patterns of knowledge to be explored or processed; (3) fully interchangeable mediating representations operating on knowledge maps; (4) a uniform set of knowledge editing operations in the mediating representations, and (5) masks for highlighting and controlling the visibility of concepts. CODE4 has had a significant amount of serious use by users in such diverse fields as terminology, organizational modelling and software engineering. This has served as the basis for validating the above ideas about knowledge organization. To this end, several techniques have been used including: (1) a detailed questionnaire about CODE4 administered to many users, and (2) a static analysis of the knowledge bases using several newly-developed metrics. The metrics include seven largely independent measures of knowledge base complexity, as well as compound measures that allow the user to ascertain the completeness, well-formedness and information-richness of a knowledge base.
L'urbanisation spontanée au Cameroun et la déviance : le cas de Ngaoundal.
Creators: name: Tiamuh, Aloysius.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1993
Subjects: subject: Sociology, Criminology and Penology.

description: L'objet de cette etude est d'identifier le lien qui existe entre l'urbanisation (spontanee), l'industrialisation en tant qu'indicateurs de developpement, et la delinquance dans les societes subissant une transformation socio-culturelle. Cette etude tente de localiser dans la societe camerounaise, subissant des transformations socio-culturelles, le probleme de la deviance et de la criminalite dans un contexte sociologique et anthropologique mais aussi d'identifier les mecanismes de reaction sociale en jeu (formels et informels) ainsi que d'evaluer plus ou moins leur dynamique propre. Ainsi, nous tentons d'indiquer quelques directions dans lesquelles de futures enquetes criminologiques en Afrique Noire pourraient etre orientees afin qu'on puisse y concevoir des politiques criminelles approppriees. La presente etude souligne quelques aspects sociologiques particuliers et typiques des societes urbaines africaines, surtout des villes naissantes, qui "predisposent" celles-ci a certains comportements deviants et qui font de sorte qu'une comparaison entre la criminalite de ces societes du Tiers monde et celle des societes des pays occidentaux serait irrealiste. Les parametres de comparaison sont difficiles a definir. Notre etude examine egalement la contradiction nee des systemes de droit (droit positif et droit coutumier) en vigueur dans des societes urbaines africaines, ainsi que l'impact de cette contradiction sur la deviance et la criminalite. (Abstract shortened by UMI.)
3048512.pdf
Creators: name: Anton, Carlos
name: Hilaire, Paul
name: Kessler, Christian
name: demory, justin
name: Carbonell, Carmen Gomez
name: Lemaitre, Aristide
name: Sagnes, Isabelle
name: Lanzillotti-Kimura, Norberto
name: Krebs, Olivier
name: Somaschi, Niccolo
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: The Supplemental Document provides details on the theoretical model used to simulate the polarization tomography experiments
Apoptotic Caspases Suppress Expression of Endogenous Retroviruses in HPV31+ Cells That Are Associated with Activation of an Innate Immune Response
Creators: name: Moody, Cary
name: Moscoso, Samantha
name: Damania, Blossom
name: Zhang, Huirong
name: Huang, Ning
name: Studstill, Caleb
name: Sundstrom, Shelby
Publisher: name: MDPI
Year: 2024

description: Avoidance of an immune response is critical to completion of the human papillomavirus (HPV) life cycle, which occurs in the stratified epithelium and is linked to epithelial differentiation. We previously demonstrated that high-risk HPVs use apoptotic caspases to suppress an antiviral innate immune response during the productive phase of the life cycle. We found that caspase-8 and caspase-3 suppress a type I IFN-β and type III IFN-λ response by disabling the MDA5/MAVS double-stranded RNA (dsRNA) sensing pathway, indicating that immunogenic RNAs increase upon differentiation in HPV+ cells. In this study, we demonstrate that caspase inhibition results in aberrant transcription of a subset of endogenous retroviruses (ERVs) that have been shown to activate an IFN response through dsRNA-sensing pathways. We show that the increase in ERV transcription is accompanied by an enrichment in dsRNA formation. Additionally, we demonstrate that the robust increase in ERV expression requires activation of the JAK/STAT-signaling pathway, indicating that this subset of ERVs is IFN-inducible. Overall, these results suggest a model by which caspase activity blocks the reactivation of ERVs through the JAK/STAT pathway, protecting HPV+ cells from an increase in immunogenic dsRNAs that otherwise would trigger an IFN response that inhibits productive viral replication.
Microstructural design of 2D and 3D photonic crystals via topology optimization
Creators: name: Fei, Meng
Publisher: name: Swinburne
Year: 2024

description: Photonic crystals are periodic microstructures composed of two or more materials with different electromagnetic properties. They can modulate light waves with specific wavelengths and generate unusual optical phenomena. The property of photonic crystals relies on the spatial distribution of material. This study develops a topology optimization approach to systematically design the microstructure of photonic crystals. Innovative 2D and 3D photonic crystal designs with maximized photonic band gaps, complete band gaps and, all-angle negative refraction ranges are obtained, the connection between their geometry characteristics and physical properties are analyzed.
Novels of Ocean-Crossing: A Homage to Vibrant Lives Across the Oceans
Creators: name: Kim, Nayoung
Publisher: name: Brandeis University
Year: 2024
Subjects: alternative dissertation
memory
ocean-crossing novels
sensory experience
storytelling
Migration

description: This dissertation is an attempt to tell a modest yet resonating story that is at once literary, critical, and personal through the contemporary global novels written in English that span the places surrounding the Pacific Ocean.
description: As a literary story, this project reads and finds unexpected connections among novels which talk about the experiences of crossing the oceans, ranging from North and South Americas, Australia, Southeast Asia, and the far East in Russia. As a critical story, it says that a migration narrative is not always massive, historical, and impersonal but can be small, sensuous, and personal as you would expect in nature writings. As a personal story, it follows and conjures up my memories of Pacific-crossing which shaped how I view, read, and understand the experiences of moving around the world which may or may not lead to finding new homes and relationships.
description: As you can see, these three stories are not exclusive. Rather, they feed each other. Each becomes a new entry point to the others, often showing that things that appear entirely unrelated can connect—such as the quiet and uneventful lives in the Kamchatka peninsula and whimsical and fantastical events in the Brazilian rainforest; such as my love for interior design and Michelle de Kretser’s multifaceted ocean-crossing story. All essays in this project contain such apparently random connections that are found in words, colors, sounds, and even smells.
description: So when it came to tell this porous yet connected story, it made most sense that I chose a way that best reflected such porous-woven nature which was literally not literal. I decided to make a website and populate it with words, images, and sounds, just like the story that I wanted to tell. And just like this story connected memories and people that were ocean apart, a website would reach readers who were ocean apart from me.
description: There is no table of contents to guide you from the beginning to end. There is no right order to read. You can close your eyes and start from wherever your blind tap landed. Let that first tap lead you to the next. And the next. That is how memories move in us.
title: บทเรียนแห่งความสำเร็จจากการน้อมนำหลักปรัชญาของเศรษฐกิจพอเพียงไปใช้ในด้านการเกษตร
Creators: name: โสภิศ  อินทสโร
Publisher: name: คณะเทคโนโลยีการเกษตร มหาวิทยาลัยราชภัฏมหาสารคาม
publisherIdentifierScheme: ROR
Year: 2025
Subjects: การถอดบทเรียน
บทเรียนความสำเร็จ
ปรัชญาของเศรษฐกิจพอเพียง

description: วารสารเกษตรพระวรุณ, 22, 1, 40-47
3048512.pdf
Creators: name: Anton, Carlos
name: Hilaire, Paul
name: Kessler, Christian
name: demory, justin
name: Carbonell, Carmen Gomez
name: Lemaitre, Aristide
name: Sagnes, Isabelle
name: Lanzillotti-Kimura, Norberto
name: Krebs, Olivier
name: Somaschi, Niccolo
Publisher: name: Optica Publishing Group
Year: 2017
Subjects: Uncategorized

description: The Supplemental Document provides details on the theoretical model used to simulate the polarization tomography experiments
Cost-Effective Techniques to Improve the Performance and Efficiency of CdTe Solar Modules
Creators: name: Al-Hamdi, Tawfeeq Kadheem
Publisher: name: Washington State University
Year: 2019
Subjects: Photovoltaic power generation -- Cooling

description: The shortage in supplying the electricity has stimulated many countries to generate more electricity from clean sources such as utilizing the solar energy in producing the required electricity through using the photovoltaics (PV) technology. Recently, the competition between different PV technologies has started to control the biggest portion of the electricity market. Cadmium telluride (CdTe) PV technology has many traits over the silicon one. However, the decline in the performance because of the increase in their temperature, their high initial investment cost, and low efficiency because the low open-circuit voltage (Voc) could all together limit the extensive utilization of CdTe solar modules. A simple, cheap, and commercially applicable passive cooling mechanism has been presented to mitigate the elevated temperatures problem. It uses a flat sheet of aluminum to perform dual functions; a flat solar concentrator and a heat extractor. The high initial investment cost and the low Voc of the CdTe solar module have been addressed by presenting new cost-effective and doped absorber materials with tailored characteristics to enable high-efficiency CdTe solar modules. High-pressure Bridgman (HPB) technique has been used to achieve this dual-task by combining the synthesize, growth, and doping of CdTe and CdSeTe feedstock materials for CdTe solar modules into one process.The results of the passive cooling technique showed that a concentrator angle of 30o to 40o from the vertical with a thickness of 0.01905 m would be the best selection to guarantee a good balance between high output power and high efficiency for the CdTe solar module. The synthesis, growth, and doping of the feedstock materials have been successfully conducted into a single step by using the HPB. The HPB offers higher growth rates, lower growth time, higher purity than other growth techniques, and the feedstock materials mass could be scaled to more than >20 kg with a cost reduction of 45% per kg. The measured active doping concentration was ~1017 cm-3 and bulk lifetime was from 5 to 40 ns in a deposited solar cell which can raise the efficiency of CdTe solar modules above the present record.
title: การเปรียบเทียบวิธีพยากรณ์ทางอนุกรมเวลาของราคาสับปะรดปัตตาเวียส่งโรงงาน
Creators: name: วรางคณา เรียนสุทธิ์
Publisher: name: คณะวิทยาศาสตร์ มหาวิทยาลัยขอนแก่น
publisherIdentifierScheme: ROR
Year: 2025
Subjects: ราคาสินค้าเกษตร
บ็อกซ์และเจนกินส์
การทำให้เรียบแบบเลขชี้กำลัง
การรวมค่าพยากรณ์

description: KKU Science Journal, 53, 2, 112-123
Increasing quality, throughput and speed of sample preparation for strand-specific messenger RNA sequencing
Creators: name: Haile, Simon
name: Corbett, Richard D.
name: MacLeod, Tina
name: Bilobram, Steve
name: Smailus, Duane
name: Tsao, Philip
name: Kirk, Heather
name: McDonald, Helen
name: Pandoh, Pawan
name: Bala, Miruna
name: Hirst, Martin
name: Miller, Diane
name: Moore, Richard A.
name: Mungall, Andrew J.
name: Schein, Jacquie
name: Coope, Robin J.
name: Ma, Yussanne
name: Zhao, Yongjun
name: Holt, Rob A.
name: Jones, Steven J. M.
name: Marra, Marco, 1966-
Publisher: name: BioMed Central
Year: 2018

description: Background RNA-Sequencing (RNA-seq) is now commonly used to reveal quantitative spatiotemporal snapshots of the transcriptome, the structures of transcripts (splice variants and fusions) and landscapes of expressed mutations. However, standard approaches for library construction typically require relatively high amounts of input RNA, are labor intensive, and are time consuming. Methods Here, we report the outcome of a systematic effort to optimize and streamline steps in strand-specific RNA-seq library construction. Results This work has resulted in the identification of an optimized messenger RNA isolation protocol, a potent reverse transcriptase for cDNA synthesis, and an efficient chemistry and a simplified formulation of library construction reagents. We also present an optimization of bead-based purification and size selection designed to maximize the recovery of cDNA fragments. Conclusions These developments have allowed us to assemble a rapid high throughput pipeline that produces high quality data from amounts of total RNA as low as 25 ng. While the focus of this study is on RNA-seq sample preparation, some of these developments are also relevant to other next-generation sequencing library types.
title: ความหลากชนิดของพรรณพืชที่มีเนื้อไม้ในป่าชุมชนไผ่กอเดียว อำเภอห้วยแถลง จังหวัดนครราชสีมา
Creators: name: เทียมหทัย ชูพันธ์
Publisher: name: คณะวิทยาศาสตร์ มหาวิทยาลัยขอนแก่น
publisherIdentifierScheme: ROR
Year: 2025
Subjects: ชนิดพืช
ป่าชุมชน
ความหลากหลาย
สถานภาพการอนุรักษ์

description: KKU Science Journal, 53, 2, 124-133
Catecholamine secretion during hypoxia in nicotinic receptor-desensitised rainbow trout, Oncorhynchus mykiss.
Creators: name: Lapner, Katherine Nancy.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Biology, Animal Physiology.

description: Experiments were performed in vivo using an extra-corporeal blood loop (EC-loop), on chronically cannulated adult rainbow trout ( Oncorhynchus mykiss) to determine whether the ability of fish to respond to acute hypoxia was impaired by an intravenous nicotine infusion (1.3 x 10-5 mol kg-1 h -1; designed to desensitise chromaffin nicotinic receptors). Respiratory and cardiovascular measurements taken throughout the nicotine infusion of the desensitisation protocol indicate that non-chromaffin, neuronal nicotinic receptors also appear to be stimulated and to desensitise. The next set of experiments showed that despite nicotinic receptor desensitisation induced by intravenous infusion of nicotine, plasma catecholamine levels were increased to similar levels (adrenaline plus noradrenaline = 125--200 nmol l-1) as in control fish during severe hypoxia (40--45 mm Hg). (Abstract shortened by UMI.)
"AYN-UL HAYOT "QASIDASINING NASHRLARIDAGI TAFOVUTLAR.
Creators: name: Muxtorova, Dildora
Publisher: name: Zenodo
Year: 2025

description: Buyuk mutafakkir  Alisher Navoiyning  “Sittayi zaruriya” qasidasi  O’rta Osiyo , arab va eron xalqlari  she’riyatida katta o’rin tutgan .Qasida janri lirikaning rivojida muhim rol o’ynagan . Qasidago’ylik XIV –XV asrlarga kelib o’zbek shoirlari orasida keng tarqalgan edi. Sharq adabiyotida qadimgi davrlardan beri mavjud bo’lgan qasida ,ayniqsa Navoiy va uning zamondoshlari ijodida  yuqori pag’onaga ko’tarildi. Shuning uchun  bu davr  qasidago’yligi  va uning an’analarini o’rganmay turib ,O’zbek adabiyotining rivoji haqida ,ayniqsa ,Navoiy ijodi haqida tugal bir fikr aytish qiyin. Lekin  shunga qaramay ,hozirgacha o’zbek klassik adabiyotida ham bu masala  durustroq o’rganilmagan.
Transfers of Care in the SMA Community: Patient perspectives of adult and pediatric care settings
Creators: name: Smith, Jesika
Publisher: name: Brandeis University
Year: 2023
Subjects: genetic counseling
spinal muscular atrophy
transfers of care
transition planning

description: Spinal muscular atrophy (SMA) is a genetic, neuromuscular disease that causes progressive muscle weakness. With the recent development of life-extending and function-preserving medications, many pediatric patients are living into adulthood. Transition planning is the process of increasing responsibility of healthcare tasks as one ages. Transfer of care is moving from one care setting to another. Few studies have assessed transition and transfer processes in the adult SMA population, and even fewer studies have assessed the involvement of genetic counselors in this space. This study surveyed 47 adults with SMA about their experience in pediatric and adult care settings. The results suggest that the transfer process from pediatric to adult care is happening, with over 90% of middle and older adult respondents (ages 31+) currently receiving care in an adult setting. However, transfers are reported as unsupported and abrupt. Genetic counselors are largely missing from conversations regarding these processes, as 0% of respondents reported speaking with a genetic counselor about transitions and transfer of care. 75% of respondents were open to discussing reproductive health and family planning at their place of primary SMA care, but only 25% reported having those conversations (p value =0.03). These findings suggest there is a demand for education regarding adult and forward-thinking health topics, and we believe that genetic counselors are a valuable resource for initiating and supporting these conversations in a clinical setting. Keywords: genetic counseling, spinal muscular atrophy, transition planning, transfer of care
Effects of adherence to a Mediterranean style diet and healthy lifestyle on cognitive functioning in independently living older individuals
Creators: name: Hardman, Roy
Publisher: name: Swinburne
Year: 2024

description: The focus of this research was to investigate the effects of diet and exercise interventions on cognition and health in older individuals, living independently. The outcomes suggest that diet quality is associated with faster cognitive processing, once medication use had been taken into account. Secondly, increased adherence to a Mediterranean diet combined with more exercise, over the 6 month intervention period improved memory and mood. This research has supported the proposition that by maintaining a healthier lifestyle, there is potential to improve cognition and mood in an ageing population with the potential to minimise the impact of dementia.
Erratum to: Do epinephrine auto-injectors have an unsuitable needle length in children and adolescents at risk for anaphylaxis from food allergy?
Creators: name: Dreborg, Sten
name: Wen, Xia
name: Kim, Laura
name: Tsai, Gina
name: Nevis, Immaculate
name: Potts, Ryan
name: Chiu, Jack
name: Dominic, Arunmozhi
name: Kim, Harold
Publisher: name: BioMed Central
Year: 2018

Abstract
Thermal transpiration in the slip flow regime.
Creators: name: Tang, Lak-Tee.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1970
Subjects: subject: Engineering, Mechanical.

description: The problem of thermal transpiration in the slip flow regime is studied from both theoretical and experimental aspects. Theoretical results are derived using boundary conditions obtained from kinetic theory considerations. Grad's method of solution of Boltzmann's equation is used to develop the slip velocity at the boundary. Consideration is also given here to surface interaction effects. Experiments have been carried out at Knudsen numbers from about 0.01 to 0.15. The theory is found to agree well with both the experimental data of Arney and Bailey and with the data reported here if sigma, the fraction of molecules reflected diffusely, is assumed to be about 0.8. Theoretical pressure ratio vs. temperature ratio results are plotted in graphs with Knudsen number and sigma as parameters.
Assessing generalizability of an AI-based visual test for cervical cancer screening
Creators: name: Mungo C
name: Saidu R.
name: Luckett R.
name: Alfaro K
name: Schiffman M
name: Ahmed S.R
name: Sanjose S.D.
name: Jeronimo J
name: Gage J.C.
name: Raiol T.
name: Egemen D
name: Charoenkwan K
name: Teran C
name: Fokom-Domgue J
name: Kalpathy-Cramer J.
name: Desai K
name: Rodriguez A.C
name: Befano B
name: Ribeiro A.
Publisher: name: Public Library of Science
Year: 2024

description: A number of challenges hinder artificial intelligence (AI) models from effective clinical translation. Foremost among these challenges is the lack of generalizability, which is defined as the ability of a model to perform well on datasets that have different characteristics from the training data. We recently investigated the development of an AI pipeline on digital images of the cervix, utilizing a multi-heterogeneous dataset of 9,462 women (17,013 images) and a multi-stage model selection and optimization approach, to generate a diagnostic classifier able to classify images of the cervix into “normal”, “indeterminate” and “precancer/cancer” (denoted as “precancer+”) categories. In this work, we investigate the performance of this multiclass classifier on external data not utilized in training and internal validation, to assess the generalizability of the classifier when moving to new settings. We assessed both the classification performance and repeatability of our classifier model across the two axes of heterogeneity present in our dataset: image capture device and geography, utilizing both out-of-the-box inference and retraining with external data. Our results demonstrate that device-level heterogeneity affects our model performance more than geography-level heterogeneity. Classification performance of our model is strong on images from a new geography without retraining, while incremental retraining with inclusion of images from a new device progressively improves classification performance on that device up to a point of saturation. Repeatability of our model is relatively unaffected by data heterogeneity and remains strong throughout. Our work supports the need for optimized retraining approaches that address data heterogeneity (e.g., when moving to a new device) to facilitate effective use of AI models in new settings.
title: Estimation of creatinine clearance using plasma creatinine or cystatin C
title: a secondary analysis of two pharmacokinetic studies in surgical ICU patients
titleType: Subtitle
Creators: name: Steinke, Thomas
name: Moritz, Stefan
name: Beck, Stefanie
name: Gnewuch, Carsten
name: Kees, Martin G.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: Pharmacokinetics
subject: Drug dosing
subject: Glomerular filtration
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik

description: Background In ICU patients, glomerular filtration is often impaired, but also supraphysiological values are observed (“augmented renal clearance”, >130 mL/min/1.73 m2). Renally eliminated drugs (e.g. many antibiotics) must be adjusted accordingly, which requires a quantitative measure of renal function throughout all the range of clinically encountered values. Estimation from plasma creatinine is standard, but cystatin C may be a valuable alternative. Methods This was a secondary analysis of renal function parameters in 100 ICU patients from two pharmacokinetic studies on vancomycin and betalactam antibiotics. Estimated clearance values obtained by the Cockcroft-Gault formula (eCLCG), the CKD-EPI formula (eCLCKD-EPI) or the cystatin C based Hoek formula (eCLHoek) were compared with the measured endogenous creatinine clearance (CLCR). Agreement of values was assessed by modified Bland-Altman plots and by calculating bias (median error) and precision (median absolute error). Sensitivity and specificity of estimates to identify patients with reduced (<60 mL/min/1.73 m2) or augmented (>130 mL/min/1.73 m2) CLCR were calculated. Results The CLCR was well distributed from highly compromised to supraphysiological values (median 73.2, range 16.8-234 mL/min/1.73 m2), even when plasma creatinine was not elevated (≤0.8 mg/dL for women, ≤1.1 mg/dL for men). Bias and precision were +13.5 mL/min/1.73 m2 and ±18.5 mL/min/1.73 m2 for eCLCG, +7.59 and ±16.8 mL/min/1.73 m2 for eCLCKD-EPI, and -4.15 and ±12.9 mL/min/1.73 m2 for eCLHoek, respectively, with eCLHoek being more precise than the other two (p
Biomaterials Based on Noncovalent Interactions of Small Molecules
Creators: name: Guo, Jiaqi
Publisher: name: Brandeis University
Year: 2024
Subjects: Biomaterials
Small molecules

description: Unlike conventional materials that covalent bonds connecting atoms are the major force to hold the materials together, supramolecular biomaterials rely on noncovalent intermolecular interactions to assemble. The reversibility and biocompatibility of supramolecular biomaterials render them with diverse range of functions and lead to rapid development in the past two decades. This thesis focuses on exploring the noncovalent and enzymatic/nonenzymatic mechanisms governing the regulation of supramolecular biomaterials, aiming to control self-assembly for diverse biomedical applications. Each chapter of this thesis highlights exemplary applications of supramolecular biomaterials across three distinct categories: tissue engineering, cancer therapy, and drug delivery. Through the exploration of these applications, the works in the thesis intend to show that enzymatic control of intermolecular interactions is a powerful tool for achieving spatiotemporal control both in vitro and in vivo.
Assessing Fragile X Premutation Carriers' Knowledge of the Premutation Phenotype
Creators: name: Metterville, Danielle R.
Publisher: name: Brandeis University
Year: 2009
Subjects: FXPOI
Fragile X syndrome
Fragile X premutation
Premutation carrier
Fragile X-associated tremor/ataxia syndrome
Fragile X-associated primary ovarian insufficiency
FXTAS
Genetic counseling

description: Fragile X syndrome (FXS) is the most common form of inherited cognitive impairment and a known genetic cause of autism. Initially, carriers of the FXS premutation were thought to only be at risk for having a child or grandchild with FXS. However, it has been found that premutation carriers are at risk for conditions not seen in carriers of the full mutation, namely fragile X-associated primary ovarian insufficiency (FXPOI) in females and fragile X-associated tremor/ataxia syndrome (FXTAS) predominantly in males. The aim of this study was to assess if premutation carriers are well informed about FXPOI and FXTAS and to ascertain which resources they find the most useful. We recruited premutation carriers through FXS related websites/listservs and provided a link to an online, anonymous survey, which consisted of questions regarding FXPOI and FXTAS knowledge, personal/family history and resource identification. A total of 43 respondents completed the survey. We found that most premutation carriers are aware of FXPOI and FXTAS. The majority of respondents learned of FXPOI and FXTAS from Internet websites and consider the Internet the most useful resource for gathering information. Most respondents believe the best time to inform a premutation carrier of FXPOI and FXTAS is at the time of diagnosis. Based on survey responses we therefore recommend 1) introducing the discussion of FXPOI and FXTAS at the time of premutation carrier diagnosis 2) referring the patient to reliable Internet resources and 3) establishing a genetic counseling relationship with the patient to continue a thorough discussion of the implications of carrying a premutation. In addition, one area in which genetic counselors can be of great benefit to the FX community is the education of other healthcare providers on FXS, FXPOI, FXTAS and the multigenerational presentation of these conditions.
Improving the security services of the message handling systems in X.400.
Creators: name: Liu, Jingsong.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Computer Science.

description: This thesis studies some security problems in the X.400 Message Handling System (MHS). It focuses on the so-called message-token, a cryptological data structure, used to convey the security-related information and support several basic security services in X.400 MHS. The current X.400 message-token which conforms to the X.509 one-way authentication protocol cannot protect X.400 messages from the attack of impersonation. An exisiting solution in terms of the one-way authentication protocol still cannot solve this problem when it is applied as a message-token in MHS. This thesis develops three new message-tokens for solving the problem. Correctness of the new message-tokens is proved by means of the authentication logic, a formal analysis technique for checking if authentication protocols are able to achieve their goals. Through the study, some weaknesses have been found in the postulates known as the Hash-Function Rules. New Hash-Function Rules are proposed for improving the authentication logic. The newly proposed message-tokens are proved to be capable of ensuring the integrity and originality of the conveyed information and thus prevent the impersonation threat for X.400 messages.
L'idéal de l'authenticité chez Charles Taylor : une redéfinition de l'individualisme contemporain.
Creators: name: Fortin, Josée.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Philosophy.

description: Cette thèse vise en premier lieu la compréhension et l'analyse de la conception de l'individualisme chez Charles Taylor. L'individualisme constitue sans équivoque le mode de vie privilégié des sociétés occidentales. Or, il est souvent perçu comme une cause de la fragmentation sociale et de l'isolement des individus. Il fait l'objet d'analyses sérieuses parmi les penseurs éthiques et politiques modernes. L'originalité de la pensée de Taylor, philosophe canadien de renommée internationale, réside principalement dans un idéal d'authenticité qu'il voit à la source de l'individualisme moderne. Il propose en fait une redéfinition de l'individualisme, un individualisme authentique , qui jette selon lui les bases d'un nouveau modèle de société. L'objectif de ce mémoire consiste donc dans un premier temps à analyser le plus fidèlement possible la conception de l'individualisme authentique chez Charles Taylor, pour en comprendre l'origine historique d'une part et les implications sociales possibles d'autre part. Dans un deuxième temps, ce mémoire démontre comment l'éthique de l'authenticité constitue la pierre angulaire de la pensée taylorienne, et ce au plan moral, politique et religieux, démonstration qui ne semble pas avoir été faite jusqu'à présent.
Illicit Affairs: An Analysis of Criminal Agency in Transnational Organized Crime
Creators: name: Fu, Alyssa
Publisher: name: Brandeis University
Year: 2022
Subjects: transnational
connectivity
criminal mobility
International Relations
Organized Crime

description: Inspired by the fast-paced developments in international relations and their effects on migration networks in our post-pandemic setting, this thesis examines a sector of society that is often overlooked: the illicit underworld. The framework draws upon traditional push-and-pull factor literature to explore the expansion of organized crime through a new angle that acknowledges the significance of criminal agency in transnational movements, especially in times of crisis. A case study comparison between the Italian Cosa Nostra and the Central American Maras groups indicate similar motivations and cross-border trajectories between the United States and their respective homelands. This research synthesizes how connectivity to the state authorities, local community, and fellow members can enhance an organization's ability to adapt to disruptions regardless of origin or cultural differences. By shedding light on one facet of criminal mobility, these findings are a call to action for further understanding of the intersects between politics and crime, such that contributions in academia may eventually influence policy.
Optically Controlled Solid-Solid Phase Change Materials for Photon and Thermal Energy Storage
Creators: name: Cho, Sungwon
Publisher: name: Brandeis University
Year: 2023
Subjects: Crystallization
Energy storage
Isomerization
Molecular structure
Phase transitions
Styrylpyrylium
Adamantane
Azobenzene
Photoswitches

description: Molecular switches are molecules that reversibly transform between two or more states inresponse to external stimuli such as light, heat, electric current, and pH. These molecules havebeen studied for a wide range of applications such as drug delivery, sensing, energy storage, andnanotechnology due to the significant changes in physical and optical properties upon switching.In this thesis, I have studied the fundamental behavior of a diverse set of molecular switches thatcan switch using light (photoswitches) in the solid state. Because the isomerization ofconventional photoswitches is typically studied in dilute solution or condensed liquid phases,there is an interest in investigating solid-state isomerization, especially for energy storageapplications. By studying solid-state energy storage materials, there is hope to increase theenergy harvesting density while avoiding the potential risk of organic liquid leakage andcombustion. In my thesis, I will cover crystal-to-amorphous photoswitchable phase changematerials as well as crystal-to-crystal photoswitchable phase change materials for energy storage through different types of systems. This thesis will hopefully provide insight helpful fordesigning solid-state molecular photoswitches and their application for energy storage.
A TYPOLOGY OF DAYS EXPERIENCED IN EARLY RECOVERY AND AN EXAMINATION OF PATIENT OUTCOMES ASSOCIATED WITH INTERCLASS VARIABILITY
Creators: name: Jenkins, Garrett J.
Publisher: name: Washington State University
Year: 2024
Subjects: substance use disorders
addiction recovery
relapse
opioid use disorder
Ecological Momentary Assessment

description: Substance use disorders (SUDs) occur across a broad range of developmental periods and demographic groups with often severe consequences. The origination of SUDs is not universally understood but is acknowledged to be equifinal. It follows then, given the diversity with which individuals arrive at addiction, that there may similarly be diversity in the manner with which individuals exit addiction and both enter and maintain recovery. The current study defines early recovery using key domains from the the Addictions Neuroclinical Assessment framework (ANA), which provides an integrated theoretical approach to conceptualizing the origins of addiction but which has been applied also to the process of recovery from addiction. Ecological momentary assessment (EMA) data were collected 4x daily for 12 days from 73 individuals voluntarily seeking treatment for opioid use disorder. Data collected measured key aspects of addiction recovery as defined by the ANA. Multilevel latent class models were employed to identify the configurations in which these aspects of addiction recovery tended to occur across the 12 day study period. The optimal solution suggested there were three different level one configurations in which recovery tended to occur on a given day. Three level two clusters were identified which suggested that individuals tended to vary minimally in the level one recovery classes they experienced across days of the study. Person-level variability in these day-level recovery classes was used to predict two distal participant outcomes: sense of daily meaningfulness at the end of the study and time-to-relapse. Mixed results were discovered when examining the relationship between person-level variability in daily recovery class and sense of daily meaningfulness at the end of the study. No significant relationship was found between person-level variability in daily recovery class and time-to-relapse. Additional research should be completed utilizing similar latent variable methods to identify potential underlying recovery-related response patterns not captured in the present investigation, as well as to validate those discovered in this study.
title: A Novel Operative Procedure for Pelvic Organ Prolapse Utilizing a MRI-Visible Mesh Implant
title: Safety and Outcome of Modified Laparoscopic Bilateral Sacropexy
titleType: Subtitle
Creators: name: Joukhadar, Ralf
name: Meyberg-Solomayer, Gabriele
name: Hamza, Amr
name: Radosa, Julia
name: Bader, Werner
name: Barski, Dimitri
name: Ismaeel, Fakher
name: Schneider, Guenther
name: Solomayer, Erich
name: Baum, Sascha
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::619 Gynäkologie, Pädiatrie, Geriatrie

description: Sacropexy is a generally applied treatment of prolapse, yet there are known possible complications of it. An essential need exists for better alloplastic materials. Methods. Between April 2013 and June 2014, we performed a modified laparoscopic bilateral sacropexy (MLBS) in 10 patients using a MRI-visible PVDF mesh implant. Selected patients had prolapse POP-Q stages II-III and concomitant OAB. We studied surgery-related morbidity, anatomical and functional outcome, and mesh-visibility in MRI. Mean follow-up was 7.4 months. Results. Concomitant colporrhaphy was conducted in 1/10 patients. Anatomical success was defined as POP-Q stage 0-I. Apical success rate was 100% and remained stable. A recurrent cystocele was seen in 1/10 patients during follow-up without need for intervention. Out of 6 (6/10) patients with preoperative SUI, 5/6 were healed and 1/6 persisted. De-novo SUI was seen in 1/10 patients. Complications requiring a relaparoscopy were seen in 2/10 patients. 8/10 patients with OAB were relieved postoperatively. The first in- human magnetic resonance visualization of a prolapse mesh implant was performed and showed good quality of visualization. Conclusion. MLBS is a feasible and safe procedure with favorable anatomical and functional outcome and good concomitant healing rates of SUI and OAB. Prospective data and larger samples are required.
Changing paradigm of malnutrition among Bangladeshi women of reproductive age and gaps in national Nutrition Policies and Action Plans to tackle the emerging challenge
Creators: name: Khan, Shusmita
name: Angeles, Gustavo
name: Haider, M. Moinuddin
name: Siraj, Saiqa
name: Ahsan, Karar Zunaid
name: Iqbal, Afrin
name: Jamil, Kanta
Publisher: name: Frontiers Media SA
Year: 2024

description: Objective The main objective of this paper is to document the changing paradigm of malnutrition in Bangladesh and estimating how this is creating an intergenerational risk. This paper also examines national policy responses to tackle the silent epidemic of double burden of malnutrition. Methods Publicly available datasets of five Bangladesh Demographic and Health Surveys were used to see the changing paradigm of malnutrition among Bangladesh women. In addition to that, four national policies concerning, maternal and child health; and nutrition were reviewed using CDC’s 2013 Policy Analytical Framework. Results In Bangladesh, the share of ever-married women aged 15–49 who were underweight declined sharply between 2007 and 2017–2018, from 30 to 12%. In the same period, the proportion of women who were overweight or obese increased from 12 to 32%. Despite remarkable progress in reducing undernourishment among women, the share of well-nourished remained unchanged: 58% in 2007 and 56% in 2017–2018, mainly due to the shift in the dominant burden from undernutrition to overnutrition. This shift occurred around 2012–2013. Currently, in Bangladesh 0.8 million of births occur to overweight women and 0.5 million births occur to underweight women. If the current trend in malnutrition continues, pregnancies/births among overweight women will increase. Bangladesh’s existing relevant policies concerning maternal health and nutrition are inadequate and mostly address the underweight spectrum of malnutrition. Discussion Both forms of malnutrition pose a risk for maternal and child health. Underweight mothers are at risk of having anemia, antepartum/postpartum hemorrhage, and premature rupture of membranes. Maternal obesity increases the risk of perinatal complications, such as gestational diabetes, gestational hypertension, and cesarean deliveries. Currently, around 24% of the children are born to overweight/obese mothers and 15% to underweight mothers. Bangladesh should revise its national policies to address the double burden of malnutrition among women of reproductive age across pre-conception, pregnancy, and post-natal stages to ensure optimum maternal and child health.
Cuticular Waxes of Arabidopsis thaliana Shoots: Cell-Type-Specific Composition and Biosynthesis
Creators: name: Hegebarth, Daniela
name: Jetter, Reinhard, 1962-
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: It is generally assumed that all plant epidermis cells are covered with cuticles, and the distinct surface geometries of pavement cells, guard cells, and trichomes imply functional differences and possibly different wax compositions. However, experiments probing cell-type-specific wax compositions and biosynthesis have been lacking until recently. This review summarizes new evidence showing that Arabidopsis trichomes have fewer wax compound classes than pavement cells, and higher amounts of especially long-chain hydrocarbons. The biosynthesis machinery generating this characteristic surface coating is discussed. Interestingly, wax compounds with similar, long hydrocarbon chains had been identified previously in some unrelated species, not all of them bearing trichomes.
Kitsap County 4-H Newsletter, March 2020
Creators: name: Washington State University Kitsap County Extension
Publisher: name: Washington State University
Year: 2020
Subjects: 4-H Club

description: Contents:
description: New WSU Phone Numbers
description: Important Dates
description: In the Spotlight
description: What's Happening in 4-H in Kitsap County
description: State~National~International 4-H Opportunities
description: 4-H Fundraisers
description: Scholarship Opportunities
description: Volunteer News
description: 4-H Trivia
description: 4-H Office Contact Information
Moment-Based Opacity Optimization
Creators: name: Zeidan, Mahmoud
name: Rapp, Tobias
name: Peters, Christoph
name: Dachsbacher, Carsten
Publisher: name: Karlsruhe
Year: 2020

description: Geometric structures such as points, lines, and surfaces play a vital role in scientific visualization. However, these visualizations frequently suffer from visual clutter that hinders the inspection of important features behind dense but less important features. In the past few years, geometric cluttering and occlusion avoidance has been addressed in scientific visualization with various approaches such as opacity optimization techniques. In this paper, we present a novel approach for opacity optimization based on recent state-of-the-art moment-based techniques for signal reconstruction. In contrast to truncated Fourier series, momentbased reconstructions of feature importance and optical depth along view rays are highly accurate for sparse regions but also plausible for densely covered regions. At the same time, moment-based methods do not suffer from ringing artifacts. Moreover, this representation enables fast evaluation and compact storage, which is crucial for per-pixel optimization especially for large geometric structures. We also present a fast screen space filtering approach for optimized opacities that works directly on moment buffers. This filtering approach is suitable for real-time visualization applications, while providing comparable quality to object space smoothing. Its implementation is independent of the type of geometry such that it is general and easy to integrate. We compare our technique to recent state of the art techniques for opacity optimization and apply it to real and synthetic data sets in various applications.
Knowledge translation for realist reviews: A participatory approach for a review on scaling up complex interventions
Creators: name: Boyko, Jennifer A.
name: Riley, Barbara L.
name: Willis, Cameron D.
name: Stockton, Lisa
name: Zummach, Dana
name: Kerner, Jon
name: Robinson, Kerry
name: Chia, Marie
Publisher: name: Swinburne
Year: 2024

description: Background: Knowledge syntheses that use a realist methodology are gaining popularity. Yet, there are few reports in the literature that describe how results are summarised, shared and used. This paper aims to inform knowledge translation (KT) for realist reviews by describing the process of developing a KT strategy for a review on pathways for scaling up complex public health interventions. Methods: The participatory approach used for the realist review was also used to develop the KT strategy. The approach included three main steps, namely (1) an international meeting focused on interpreting preliminary findings from the realist review and seeking input on KT activities; (2) a targeted literature review on KT for realist reviews; and (3) consultations with primary knowledge users of the review. Results: The international meeting identified a general preference among knowledge users for findings from the review that are action oriented. A need was also identified for understanding how to tailor findings for specific knowledge user groups in relation to their needs. The literature review identified four papers that included brief descriptions of planned or actual KT activities for specific research studies; however, information was minimal on what KT activities or products work for whom, under what conditions and why. The consultations revealed that KT for realist reviews should consider the following: (1) activities closely aligned with the preferences of specific knowledge user groups; (2) key findings that are sensitive to factors within the knowledge user's context; and (3) actionable statements that can advance KT goals, activities or products. The KT strategy derived from the three activities includes a planning framework and tailored KT activities that address preferences of knowledge users for findings that are action oriented and context relevant. Conclusions: This paper provides an example of a KT strategy for realist reviews that blends theoretical and practical insights. Evaluation of the strategy's implementation will provide useful insights on its effectiveness and potential for broader application.