cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Genomic mapping of social behavior traits in a F2 cross derived from mice selectively bred for high aggression
Creators: name: Nehrenberg, Derrick L
name: Perkins, James
name: Wang, Shiliang
name: Buus, Ryan J
name: Pomp, Daniel
name: Pardo-Manuel de Villena, Fernando
Publisher: name: BioMed Central Ltd
Year: 2010

description: Abstract Background Rapid response to selection was previously observed in mice selected for high levels of inter-male aggression based on number of attacks displayed in a novel social interaction test after isolation housing. Attack levels in this high aggression line (NC900) increased significantly within just four generations of selective breeding, suggesting the presence of a locus with large effect. We conducted an experiment using a small (n ≈ 100) F2 cross between the ICR-derived, non-inbred NC900 strain and the low aggression inbred strain C57BL/6J, genotyped for 154 fully informative SNPs, to determine if a locus with large effect controls the high-aggression selection trait. A second goal was to use high density SNP genotyping (n = 549,000) in the parental strains to characterize residual patterns of heterozygosity within NC900, and evaluate regions that are identical by descent (IBD) between NC900 and C57BL/6J, to determine what impacts these may have on accuracy and resolution of quantitative trait locus (QTL) mapping in the F2 cross. Results No evidence for a locus with major effect on aggressive behavior in mice was identified. However, several QTL with genomewide significance were mapped for aggression on chromosomes 7 and 19 and other social behavior traits on chromosomes 4, 7, 14, and 19. High density genotyping revealed that 28% of the genome is still segregating among the six NC900 females used to originate the F2 cross, and that segregating regions are present on every chromosome but are of widely different sizes. Regions of IBD between NC900 and C57BL/6J are found on every chromosome but are most prominent on chromosomes 10, 16 and X. No significant differences were found for amounts of heterozygosity or prevalence of IBD in QTL regions relative to global analysis. Conclusions While no major gene was identified to explain the rapid selection response in the NC900 line, transgressive variation (i.e. where the allele from the C57BL/6J increased attack levels) and a significant role for dominant gene action were hallmarks of the genetic architecture for aggressive behavior uncovered in this study. The high levels of heterozygosity and the distribution of minor allele frequency observed in the NC900 population suggest that maintenance of heterozygosity may have been under selection in this line.
Kicking as movement in infants to early detection and intervention: a scoping review
Creators: name: Merino-Andrés, Javier
name: Robles, Álvaro
name: Marín, María
name: del Río García, María
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Physiotherapy
subject: Kinesiotherapy
subject: Medicine and Health Sciences
subject: Rehabilitation and Therapy
subject: Physical Therapy

description: Scoping review to map evidence supporting use of kicking movement in infants to use as early detection and intervention
Epstein-Barr virus-specific methylation of human genes in gastric cancer cells
Creators: name: Rivenbark, Ashley G
name: Tang, Weihua
name: Coleman, William
name: Knight, Elizabeth RW
name: Gulley, Margaret L
Publisher: name: BioMed Central Ltd
Year: 2010

description: Abstract Background Epstein-Barr Virus (EBV) is found in 10% of all gastric adenocarcinomas but its role in tumor development and maintenance remains unclear. The objective of this study was to examine EBV-mediated dysregulation of cellular factors implicated in gastric carcinogenesis. Methods Gene expression patterns were examined in EBV-negative and EBV-positive AGS gastric epithelial cells using a low density microarray, reverse transcription PCR, histochemical stains, and methylation-specific DNA sequencing. Expression of PTGS2 (COX2) was measured in AGS cells and in primary gastric adenocarcinoma tissues. Results In array studies, nearly half of the 96 human genes tested, representing 15 different cancer-related signal transduction pathways, were dysregulated after EBV infection. Reverse transcription PCR confirmed significant impact on factors having diverse functions such as cell cycle regulation (IGFBP3, CDKN2A, CCND1, HSP70, ID2, ID4), DNA repair (BRCA1, TFF1), cell adhesion (ICAM1), inflammation (COX2), and angiogenesis (HIF1A). Demethylation using 5-aza-2'-deoxycytidine reversed the EBV-mediated dysregulation for all 11 genes listed here. For some promoter sequences, CpG island methylation and demethylation occurred in an EBV-specific pattern as shown by bisulfite DNA sequencing. Immunohistochemistry was less sensitive than was western blot for detecting downregulation of COX2 upon EBV infection. Virus-related dysregulation of COX2 levels in vitro was not recapitulated in vivo among naturally infected gastric cancer tissues. Conclusions EBV alters human gene expression in ways that could contribute to the unique pathobiology of virus-associated cancer. Furthermore, the frequency and reversability of methylation-related transcriptional alterations suggest that demethylating agents have therapeutic potential for managing EBV-related carcinoma.
title: CT findings of osteoradionecrosis of the mandible
Creators: name: Abreu e Silva, Joana
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Cancer
subject: Education
subject: CT
subject: Bones

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Discuss the clinical features and the risk factors forosteoradionecrosis of the mandible. Describe the CTimaging features of...
High Speed Coherent Optical Transmission over Free Space Optics
Creators: name: Guiomar, Fernando P.
name: Fernandes, Marco A.
name: Fernandes, Gil M.
name: Monteiro, Paulo P.
Publisher: name: Zenodo
Year: 2022

description: Colloquium on FSO systems organized by the Eindhoven University of Technology (TU/e), with an invited talk delivered by Fernando Guiomar, entitled "High Speed Coherent Optical Transmission over Free Space Optics".
title: Multislice CT versus cone beam CT: dosimetric and image quality comparision.
Creators: name: Dionisi, Clizia
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Dosimetry
subject: CT
subject: Radioprotection / Radiation dose
subject: Quality assurance

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To respect the principle of optimization It is necessary to keep abreast of new technologies and compare them to those used at the time to check the actual benefits. The aim of the study is the comparison of image quality and effective doses of...
Reformulation of Boundary BF Theory Approach to Statistical Explanation of the Entropy of Isolated Horizons
Creators: name: Huang, Chao-Guang
name: Wang, Jingbo
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: It is shown in this paper that the symplectic form for the system consisting of $D$-dimensional bulk Palatini gravity and SO$(1,1)$ BF theory on an isolated horizon as a boundary just contains the bulk term. An alternative quantization procedure for the boundary BF theory is presented. The area entropy is determined by the degree of freedom of the bulk spin network states which satisfy a suitable boundary condition. The gauge-fixing condition in the approach and the advantages of the approach are also discussed.
description: 17 pages, no figures
Occupation probabilities and current densities of bulk and edge states of a Floquet topological insulator
Creators: name: Dehghani, Hossein
name: Mitra, Aditi
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Results are presented for the occupation probabilities and current densities of bulk and edge states of half-filled graphene in a cylindrical geometry, and irradiated by a circularly polarized laser. It is assumed that the system is closed, and that the laser has been switched on as a quench. Laser parameters corresponding to some representative topological phases are studied: one where the Chern number of the Floquet bands equals the number of chiral edge modes, a second where anomalous edge states appear in the Floquet Brillouin zone boundaries, and a third where the Chern number is zero, yet topological edge states appear at the center and boundaries of the Floquet Brillouin zone. Qualitative differences are found for the high frequency off-resonant and low frequency on-resonant laser with edge states arising due to resonant processes occupied with a high effective temperature on the one hand, while edge states arising due to off-resonant processes occupied with a low effective temperature on the other. For an ideal half-filled system where only one of the bands in the Floquet Brillouin zone is occupied and the other empty, particle-hole and inversion symmetry of the Floquet Hamiltonian implies zero current density. However the laser switch-on protocol breaks the inversion symmetry, resulting in a net cylindrical sheet of current density at steady-state. Due to the underlying chirality of the system, this current density profile is associated with a net charge imbalance between the top and bottom of the cylinders.
description: 16 pages, 9 figures
title: Comparison of T1rho imaging between spoiled gradient echo (SPGR) and balanced steady state free precession (b-FFE) sequence of knee cartilage at 3 tesla
Creators: name: Nozaki, Taiki
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Musculoskeletal joint
subject: MR-Functional imaging
subject: Imaging sequences
subject: Arthritides

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Osteoarthritis (OA) is one of the most prevalent disorders in today’s society, resulting in significant socio-economic costs and morbidity (1). A host of new and exciting therapeutic modalities are being developed for the treatment of OA, which...
דכאון וזכרון
Creators: name: Evron, Dan
name: Hausdorff, Tuvia
name: Michael, Gavriela
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: זהו פרוייקט שנעשה במסגרת הקורס "פסיכולוגיה ניסויית" באוניברסיטת תל אביב, שנערך בסמסטר ב 2022. במסגרת הפרוייקט, אנו עורכים ניסוי שמטרתו לבחון את הקשר בין דכאון לבין זכרון לטווח הקצר של מילים עם 'אופי' משתנה. כל חומרי הניסוי, לרבות תוצאות הניתוחים הסטטיסטיים, רשימות המילים, הפניות למאמרים, השאלונים וכלי המדידה שביצענו בהם שימוש מצורפים לפרויקט זה, כמו גם המצגות אותן בנינו כדי להציג את הפרוייקט לחברינו בכיתה.
Genetic and Other Factors Determining Mannose-binding Lectin Levels in American Indians: The Strong Heart Study
Creators: name: Ferrell, Robert E
name: DeCroo, Susan
name: North, Kari
name: Garred, Peter
name: Umans, Jason
name: Best, Lyle G
name: Lee, Elisa T
name: Zhang, Ying
name: MacCluer, Jean W
name: Howard, Barbara V
name: Palmieri, Vittorio
Publisher: name: BioMed Central Ltd
Year: 2009

description: Abstract Background Mannose-binding lectin (MBL) forms an integral part of the innate immune system. Persistent, subclinical infections and chronic inflammatory states are hypothesized to contribute to the pathogenesis of atherosclerosis. MBL gene (MBL2) variants with between 12 to 25% allele frequency in Caucasian and other populations, result in markedly reduced expression of functional protein. Prospective epidemiologic studies, including a nested, case-control study from the present population, have demonstrated the ability of MBL2 genotypes to predict complications of atherosclerosis,. The genetic control of MBL2 expression is complex and genetic background effects in specific populations are largely unknown. Methods The Strong Heart Study is a longitudinal, cohort study of cardiovascular disease among American Indians. A subset of individuals genotyped for the above mentioned case-control study were selected for analysis of circulating MBL levels by double sandwich ELISA method. Mean MBL levels were compared between genotypic groups and multivariate regression was used to determine other independent factors influencing MBL2 expression. Results Our results confirm the effects of variant structural (B, C, and D) and promoter (H and Y) alleles that have been seen in other populations. In addition, MBL levels were found to be positively associated with male gender and hemoglobin A1c levels, but inversely related to triglyceride levels. Correlation was not found between MBL and other markers of inflammation. Conclusion New data is presented concerning the effects of known genetic variants on MBL levels in an American Indian population, as well as the relationship of MBL2 expression to clinical and environmental factors, including inflammatory markers.
Electron scattering, charge order, and pseudogap physics in La$_{1.6-x}$Nd$_{0.4}$Sr$_x$CuO$_4$: An angle resolved photoemission spectroscopy study
Creators: name: Matt, Christian E.
name: Fatuzzo, Claudia G.
name: Sassa, Y.
name: Mansson, M.
name: Fatale, S.
name: Bitetta, V.
name: Shi, X.
name: Pailhes, S.
name: Berntsen, M. H.
name: Kurosawa, T.
name: Oda, M.
name: Momono, N.
name: Lipscombe, O. J.
name: Hayden, S. M.
name: Yan, J. -Q.
name: Zhou, J. -S.
name: Goodenough, J. B.
name: Pyon, S.
name: Takayama, T.
name: Takagi, H.
name: Patthey, L.
name: Bendounan, A.
name: Razzoli, E.
name: Shi, M.
name: Plumb, N. C.
name: Radovic, M.
name: Grioni, M.
name: Mesot, J.
name: Tjernberg, O.
name: Chang, J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We report an angle-resolved photoemission study of the charge stripe ordered La$_{1.6-x}$Nd$_{0.4}$Sr$_x$CuO$_4$ system. A comparative and quantitative line shape analysis is presented as the system evolves from the overdoped regime into the charge ordered phase. On the overdoped side ($x=0.20$), a normal state anti-nodal spectral gap opens upon cooling below ~ 80 K. In this process spectral weight is preserved but redistributed to larger energies. A correlation between this spectral gap and electron scattering is found. A different lineshape is observed in the antinodal region of charge ordered Nd-LSCO $x=1/8$. Significant low-energy spectral weight appears to be lost. These observations are discussed in terms of spectral weight redistribution and gapping %of spectral weight originating from charge stripe ordering.
description: Accepted by PRB
A Monte Carlo algorithm for simulating fermions on Lefschetz thimbles
Creators: name: Alexandru, Andrei
name: Basar, Gokce
name: Bedaque, Paulo
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Theory (hep-th)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: A possible solution of the notorious sign problem preventing direct Monte Carlo calculations for systems with non-zero chemical potential is to deform the integration region in the complex plane to a Lefschetz thimble. We investigate this approach for a simple fermionic model. We introduce an easy to implement Monte Carlo algorithm to sample the dominant thimble. Our algorithm relies only on the integration of the gradient flow in the numerically stable direction, which gives it a distinct advantage over the other proposed algorithms. We demonstrate the stability and efficiency of the algorithm by applying it to an exactly solvable fermionic model and compare our results with the analytical ones. We report a very good agreement for a certain region in the parameter space where the dominant contribution comes from a single thimble, including a region where standard methods suffer from a severe sign problem. However, we find that there are also regions in the parameter space where the contribution from multiple thimbles is important, even in the continuum limit.
description: 16 pages, 7 figures
Growth against entropy in bacterial metabolism: the phenotypic trade-off behind empirical growth rate distributions in E. coli
Creators: name: De Martino, Daniele
name: Capuani, Fabrizio
name: De Martino, Andrea
Publisher: name: arXiv
Year: 2016
Subjects: subject: Molecular Networks (q-bio.MN)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Biological Physics (physics.bio-ph)
subject: Populations and Evolution (q-bio.PE)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: The solution space of genome-scale models of cellular metabolism provides a map between physically viable flux configurations and cellular metabolic phenotypes described, at the most basic level, by the corresponding growth rates. By sampling the solution space of E. coli's metabolic network, we show that empirical growth rate distributions recently obtained in experiments at single-cell resolution can be explained in terms of a trade-off between the higher fitness of fast-growing phenotypes and the higher entropy of slow-growing ones. Based on this, we propose a minimal model for the evolution of a large bacterial population that captures this trade-off. The scaling relationships observed in experiments encode, in such frameworks, for the same distance from the maximum achievable growth rate, the same degree of growth rate maximization, and/or the same rate of phenotypic change. Being grounded on genome-scale metabolic network reconstructions, these results allow for multiple implications and extensions in spite of the underlying conceptual simplicity.
description: 12 pages, 5 figures
title: T1rho mapping of the entire femoral cartilage using novel depth and angle dependent analysis
Creators: name: Nozaki, Taiki
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Musculoskeletal joint
subject: MR-Functional imaging
subject: Technical aspects
subject: Arthritides

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Osteoarthritis (OA) is the most common type of arthritis and a leading cause of pain, and one of the most prevalent disorders in today’s society, resulting in significant socio-economic costs and morbidity (1). New and advanced therapeutic...
Integrated analysis of independent gene expression microarray datasets improves the predictability of breast cancer outcome
Creators: name: Zhang, Zhe
Publisher: name: BioMed Central Ltd
Year: 2007

description: Abstract Background Gene expression profiles based on microarray data have been suggested by many studies as potential molecular prognostic indexes of breast cancer. However, due to the confounding effect of clinical background, independent studies often obtained inconsistent results. The current study investigated the possibility to improve the quality and generality of expression profiles by integrated analysis of multiple datasets. Profiles of recurrence outcome were derived from two independent datasets and validated by a third dataset. Results The clinical background of patients significantly influenced the content and performance of expression profiles when the training samples were unbalanced. The integrated profiling of two independent datasets lead to higher classification accuracy (71.11% vs. 70.59%) and larger ROC curve area (0.789 vs. 0.767) of the testing samples. Cell cycle, especially M phase mitosis, was significantly overrepresented by the 60-gene profile obtained from integrated analysis (p < 0.0001). This profiles significantly differentiated poor and good prognosis in a third patient cohort (p = 0.003). Simulation procedures demonstrated that the change of profile specificity had more instant influence on the performance of expression profiles than the change of profile sensitivity. Conclusion The current study confirmed that the gene expression profile generated by integrated analysis of multiple datasets achieved better prediction of breast cancer recurrence. However, the content and performance of profiles was confounded by clinical background of training patients. In future studies, prognostic profile applicable to the general population should be derived from more diversified and balanced patient cohorts in larger scale.
Coupling all-atom molecular dynamics simulations of ions in water with Brownian dynamics
Creators: name: Erban, Radek
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computational Physics (physics.comp-ph)
subject: Subcellular Processes (q-bio.SC)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Molecular dynamics (MD) simulations of ions (K$^+$, Na$^+$, Ca$^{2+}$ and Cl$^-$) in aqueous solutions are investigated. Water is described using the SPC/E model. A stochastic coarse-grained description for ion behaviour is presented and parameterized using MD simulations. It is given as a system of coupled stochastic and ordinary differential equations, describing the ion position, velocity and acceleration. The stochastic coarse-grained model provides an intermediate description between all-atom MD simulations and Brownian dynamics (BD) models. It is used to develop a multiscale method which uses all-atom MD simulations in parts of the computational domain and (less detailed) BD simulations in the remainder of the domain.
description: Submitted to Proceedings of the Royal Society A
title: Imaging of the Post-operative Liver: Review of Normal Appearances and Common Complications
Creators: name: Mule, Sebastien
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Liver
subject: CT
subject: MR
subject: Ultrasound-Power Doppler
subject: Surgery
subject: Embolism / Thrombosis
subject: Abscess
subject: Ischaemia / Infarction

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Recent technical developments have lead to a substantial increased number of potential indications for liver surgery. Morbidity and mortality rates remain high, due to increasing number of complex surgical procedures. Imaging plays a crucial role in...
Can behaviour be modulated based on the (non-)occurrence of ⍺-bursts in the ongoing EEG signal?
Creators: name: Vigué-Guix, Irene
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Cognitive Neuroscience
subject: Life Sciences
subject: Neuroscience and Neurobiology
subject: Biological Engineering
subject: Engineering
subject: Biomedical Engineering and Bioengineering

description: This study will implement a “Go/No-go” task in which the moment of target presentation will be determined in real-time based on the (non-)occurrence of ⍺-bursts, estimated through ongoing EEG activity by means of a closed-loop BCI setting. The main aims of the study are: ● Proof-of-concept of real-time burst-triggered stimulus presentation ● Relating the ⍺-bursts to behaviour (e.g., reaction time; RT) in a “Go/No-go” task
title: Extramural Vascular Invasion at Rectal MRI: A Finding of Questionable Clinical Value
Creators: name: Maas, Monique
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Gastrointestinal tract
subject: Colon
subject: Vascular
subject: MR
subject: Diagnostic procedure
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Extramural vascular invasion (EMVI), defined as the presence of malignant cells within endothelial cell–lined blood vessels beyond the muscularis propria [1], and reported to occur in as many as 52% of cases of colorectal cancer [1-4], is a known...
Derivation of a large isotropic diffuse sky emission component at 1.25 and 2.2um from the COBE/DIRBE data
Creators: name: Sano, K.
name: Kawara, K.
name: Matsuura, S.
name: Kataza, H.
name: Arai, T.
name: Matsuoka, Y.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Using all-sky maps obtained with COBE/DIRBE, we reanalyzed the diffuse sky brightness at 1.25 and 2.2 um, which consists of zodiacal light, diffuse Galactic light (DGL), integrated starlight (ISL), and isotropic emission including the extragalactic background light. Our new analysis including an improved estimate of the DGL and the ISL with the 2MASS data showed that deviations of the isotropic emission from isotropy were less than 10% in the entire sky at high Galactic latitude (|b|>35). The result of our analysis revealed a significantly large isotropic component at 1.25 and 2.2 um with intensities of 60.15 +/- 16.14 and 27.68 +/- 6.21 nWm-2sr-1, respectively. This intensity is larger than the integrated galaxy light, upper limits from gamma-ray observation, and potential contribution from exotic sources (i.e., Population III stars, intrahalo light, direct collapse black holes, and dark stars). We therefore conclude that the excess light may originate from the local universe; the Milky Way and/or the solar system.
description: ApJ accepted
title: The Diagnostic Efficiency of Readout-segmented DWI Compared with Single-shot DWI in Acute Cerebral Infarction
Creators: name: Yin, Jianzhong
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: CNS
subject: MR
subject: Imaging sequences
subject: Ischaemia / Infarction

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The most useful clinical application of diffusion-weighted imaging (DWI) is in the early detection of brain infarction. Single-shot echo-planar imaging (ss-EPI) is well established as the method of choice for DWI, however, it is prone to a number of...
Gaining the PROMIS perspective from children with nephrotic syndrome: a Midwest pediatric nephrology consortium study
Creators: name: DeWalt, Darren A
name: Liu, Yang
name: Ferris, Maria
name: Thissen, David
Publisher: name: BioMed Central Ltd
Year: 2013

description: Abstract Background and objectives Nephrotic syndrome (NS) represents a common disease in pediatric nephrology typified by a relapsing and remitting course and characterized by the presence of edema that can significantly affect the health-related quality of life in children and adolescents. The PROMIS pediatric measures were constructed to be publically available, efficient, precise, and valid across a variety of diseases to assess patient reports of symptoms and quality of life. This study was designed to evaluate the ability of children and adolescents with NS to complete the PROMIS assessment via computer and to initiate validity assessments of the short forms and full item banks in pediatric NS. Successful measurement of patient reported outcomes will contribute to our understanding of the impact of NS on children and adolescents. Design This cross-sectional study included 151 children and adolescents 8-17 years old with NS from 16 participating institutions in North America. The children completed the PROMIS pediatric depression, anxiety, social-peer relationships, pain interference, fatigue, mobility and upper extremity functioning measures using a web-based interface. Responses were compared between patients experiencing active NS (n = 53) defined by the presence of edema and patients with inactive NS (n = 96) defined by the absence of edema. Results All 151 children and adolescents were successfully able to complete the PROMIS assessment via computer. As hypothesized, the children and adolescents with active NS were significantly different on 4 self-reported measures (anxiety, pain interference, fatigue, and mobility). Depression, peer relationships, and upper extremity functioning were not different between children with active vs. inactive NS. Multivariate analysis showed that the PROMIS instruments remained sensitive to NS disease activity after adjusting for demographic characteristics. Conclusions Children and adolescents with NS were able to successfully complete the PROMIS instrument using a web-based interface. The computer based pediatric PROMIS measurement effectively discriminated between children and adolescents with active and inactive NS. The domain scores found in this study are consistent with previous reports investigating the health-related quality of life in children and adolescents with NS. This study establishes known-group validity and feasibility for PROMIS pediatric measures in children and adolescents with NS.
title: Attitude maneuvers avoiding forbidden directions
Creators: name: Ailabouni, David
name: Meister, Andreas
name: Spindler, Karlheinz
Publisher: name: Universität Kassel
Year: 2023
Subjects: subject: attitude control
subject: pointing constraints
subject: optimal control on Lie groups
subject: Pontryagin’s Maximum
subject: Principle
subject: 510
subject: Lageregelung
subject: Lie-Gruppe
subject: Pontrjagin, Lev S.

description: Gefördert im Rahmen des Projekts DEAL
Quadrupole moments in chiral material DyFe3(BO3)4 observed by resonant x-ray diffraction
Creators: name: Nakajima, Hiroshi
name: Usui, Tomoyasu
name: Joly, Yves
name: Suzuki, Motohiro
name: Wakabayashi, Yusuke
name: Kimura, Tsuyoshi
name: Tanaka, Yoshikazu
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: By means of circularly polarized x-ray beam at Dy L3 and Fe K absorption edges, the chiral structure of the electric quadrupole was investigated for a single crystal of DyFe3(BO3)4 in which both Dy and Fe ions are arranged in spiral manners. The integrated intensity of the resonant x- ray diffraction of space-group forbidden reflections 004 and 005 is interpreted within the electric dipole transitions from Dy 2p3 to 5d and Fe 1s to 4p, respectively. We have confirmed that the 2 handedness of the crystal observed at Dy L3 and Fe K edges is consistent with that observed at Dy M5 edge in the previous study. By analyzing the azimuth scans of the diffracted intensity, the electronic quadrupole moments of Dy 5d and Fe 4p are derived. The temperature profiles of the integrated intensity of 004 at the Dy L3 and the Fe K edges are similar to those of Dy-O and Fe-O bond lengths, while that at the Dy M5 edge does not. The results indicate that the helix chiral orientations of quadrupole moments due to Dy 5d and Fe 4p electrons are more strongly affected by the crystal fields than Dy 4f.
title: Objective Assessment of NLST Criteria for the Asian Population in the Lung Cancer Screening Program
Creators: name: Yen, Yu
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Cancer
subject: Screening
subject: CT
subject: Oncology
subject: Lung
subject: eHealth

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Lung cancer is the leading cause of cancer death in the world. American National Lung Screening Trial (NLST) shows that low-dose screening CT can reduce the mortality rate of lung cancer up to 20% [1-3]. Entry criteria of NLST includes 1) current or...
Thermally-activated dynamics of spontaneous perpendicular vortices tuned by parallel magnetic fields in thin superconducting films
Creators: name: Kunchur, Milind N.
name: Liang, Manlai
name: Gurevich, Alex
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We report magneto-transport measurements on a superconducting molybdenum-germanium (MoGe) film of thickness $d$=50 nm in parallel magnetic fields and show evidence of a transition from a Meissner state to a resistive state of spontaneous perpendicular vortices generated by thermal fluctuations above a certain temperature $T>T_v(B)$. Here $T_v$ appears to match the vortex core explosion condition $d\approx 4.4ξ(T_v)$, where $ξ$ is the coherence length. For $T>T_v$, we observed that a nonlinear current-voltage ($IV$) response (Ohmic at low currents and the power law $V\propto I^β$ at higher $I$) is exponentially dependent on $B^2$. We propose a model in which the resistive state at $T>T_v$ is due to thermally-activated hopping of spontaneous perpendicular vortices tuned by the pairbreaking effect of the parallel $B$. keywords: vortex, vortices, fluxon, flux lattice, mixed state, lower critical field
A cross-sectional analysis of HIV and hepatitis C clinical trials 2007 to 2010: the relationship between industry sponsorship and randomized study design
Creators: name: Miller, William
Publisher: name: BioMed Central Ltd
Year: 2014

description: Abstract Background The proportion of clinical research sponsored by industry will likely continue to expand as federal funds for academic research decreases, particularly in the fields of HIV/AIDS and hepatitis C (HCV). While HIV and HCV continue to burden the US population, insufficient data exists as to how industry sponsorship affects clinical trials involving these infectious diseases. Debate exists about whether pharmaceutical companies undertake more market-driven research practices to promote therapeutics, or instead conduct more rigorous trials than their non-industry counterparts because of increased resources and scrutiny. The ClinicalTrials.gov registry, which allows investigators to fulfill a federal mandate for public trial registration, provides an opportunity for critical evaluation of study designs for industry-sponsored trials, independent of publication status. As part of a large public policy effort, the Clinical Trials Transformation Initiative (CTTI) recently transformed the ClinicalTrials.gov registry into a searchable dataset to facilitate research on clinical trials themselves. Methods We conducted a cross-sectional analysis of 477 HIV and HCV drug treatment trials, registered with ClinicalTrials.gov from 1 October 2007 to 27 September 2010, to study the relationship of study sponsorship with randomized study design. The likelihood of using randomization given industry (versus non-industry) sponsorship was reported with prevalence ratios (PR). PRs were estimated using crude and stratified tabular analysis and Poisson regression adjusting for presence of a data monitoring committee, enrollment size, study phase, number of study sites, inclusion of foreign study sites, exclusion of persons older than age 65, and disease condition. Results The crude PR was 1.17 (95% CI 0.94, 1.45). Adjusted Poisson models produced a PR of 1.13 (95% CI 0.82, 1.56). There was a trend toward mild effect measure modification by study phase, but this was not statistically significant. In stratified tabular analysis the adjusted PR was 1.14 (95% CI 0.78, 1.68) among phase 2/3 trials and 1.06 (95% CI 0.50, 2.22) among phase 4 trials. Conclusions No significant relationship was found between industry sponsorship and use of randomization in trial design in this cross-sectional study. Prospective studies evaluating other aspects of trial design may shed further light on the relationship between industry sponsorship and appropriate trial methodology.
On the equivalence of separability and extendability of quantum states
Creators: name: Bhat, B. V. Rajarama
name: Parthasarathy, K. R.
name: Sengupta, Ritabrata
Publisher: name: arXiv
Year: 2016
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences
subject: 81P40, 81P99, 94A15

description: Motivated by the notions of $k$-extendability and complete extendability of the state of a finite level quantum system as described by Doherty et al (Phys. Rev. A, 69:022308), we introduce parallel definitions in the context of Gaussian states and using only properties of their covariance matrices derive necessary and sufficient conditions for their complete extendability. It turns out that the complete extendability property is equivalent to the separability property of a bipartite Gaussian state. Following the proof of quantum de Finetti theorem as outlined in Hudson and Moody (Z. Wahrscheinlichkeitstheorie und Verw. Gebiete, 33(4):343--351), we show that separability is equivalent to complete extendability for a state in a bipartite Hilbert space where at least one of which is of dimension greater than 2. This, in particular, extends the result of Fannes, Lewis, and Verbeure (Lett. Math. Phys. 15(3): 255--260) to the case of an infinite dimensional Hilbert space whose C* algebra of all bounded operators is not separable.
description: Proved a conjecture proposed in earlier version. Added Theorem 2.3. Added Section 3 based on quantum de Finetty theorem. Background materials taken from 1506.06526 and 1504.07054. Comments welcome
title: PICC line trends and cost effectiveness
Creators: name: O Brien, Ciara
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Epidemiology
subject: Audit and standards
subject: Fluoroscopy
subject: Interventional vascular

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Peripherally inserted central catheters (PICC lines) are the most commonly requested procedure in most interventional radiology departments (IR). They are essentialto patients who are undergoing prolonged Intravenous treatment for...
A population-based study of prevalence and risk factors of chronic kidney disease in León, Nicaragua
Creators: name: Hogan, Susan
name: Morgan, Douglas R.
name: Lebov, Jill F.
name: Colindres, Romulo E.
Publisher: name: BioMed Central
Year: 2015

description: Abstract Background Recent studies have shown an excess of chronic kidney disease (CKD) among younger adult males in the Pacific coastal region of Nicaragua and suggest a non-conventional CKD etiology in this region. These studies have been conducted in small, non-representative populations. Objectives We conducted a large population-based cross-sectional study to estimate CKD prevalence in León, Nicaragua, and to evaluate the association between previously investigated risk factors and CKD. Methods Estimated glomerular filtration rate, derived using the MDRD equation, was assessed to determine CKD status of 2275 León residents. Multivariable logistic regression was used to estimate adjusted prevalence odds ratios. León CKD prevalence was also standardized to the demographic distributions of the León Health and Demographic Surveillance System and the León 2005 Census. Results CKD prevalence was 9.1%; twice as high for males (13.8%) than females (5.8%). In addition to gender, older age, rural zone, lower education level, and self-reported high blood pressure, more years of agricultural work, lija (unregulated alcohol) consumption, and higher levels of daily water consumption were significantly associated with CKD. Notably, self-reported diabetes was associated with CKD in adjusted models for females but not males. Conclusions Our findings are comparable to those found in regional studies and further support the hypothesis of a Mesoamerican Nephropathy.
A sequential modeling approach for predicting clinical outcomes with repeated measures
Creators: name: Shestopaloff, Konstantin
name: Canizares, Mayilee
name: Power, J. Denise
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Virology
subject: Computational Biology

description: The increased availability of healthcare data has made predictive modeling popular in a clinical setting. If an expected patient-specific outcome can be estimated prior to a medical intervention the healthcare costs can be reduced for both patient and provider. The nature of data used to train such predictive models is frequently longitudinal, as interventions with convalescence times or chronic conditions contain outcome measures at intermediate follow-up points. Here we outline a predictive modeling approach that takes advantage of the longitudinal structure of the data by sequentially predicting the outcomes at intermediate time points and including them as predictors in models for later time points. This is done for continuous and threshold-dichotomized outcomes. The proposed method improves predictive accuracy as it takes advantage of the correlation in follow-up measures to distribute the estimation of coefficient effects over several models, making it advantageous for smaller datasets. This formulation also allows for effective screening of first-order interaction effects. The improved performance is illustrated using a simulation study and an applied example of predicting outcomes following surgery. The proposed approach is shown to be consistent for prediction, effective in modeling interactions and robust to presence of noise variables.
Outflow forces in intermediate mass star formation
Creators: name: van Kempen, T. A.
name: Hogerheijde, M. R.
name: van Dishoeck, E. F.
name: Kristensen, L. E.
name: Belloche, A.
name: Klaassen, P. D.
name: Leurini, S.
name: Jose-Garcia, I. San
name: Aykutalp, A.
name: Choi, Y.
name: Endo, A.
name: Frieswijk, W.
name: Harsono, D.
name: Karska, A.
name: Koumpia, E.
name: van der Marel, N.
name: Nagy, Z.
name: Perez-Beaupuits, J. P.
name: Risacher, C.
name: van Weeren, R. J.
name: Wyrowski, F.
name: Yildiz, U. A.
name: Guesten, R.
name: Boland, W.
name: Baryshev, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Intermediate mass protostarsprovide a bridge between theories of low- and high-mass star formation. Emerging molecular outflows can be used to determine the influence of fragmentation and multiplicity on protostellar evolution through the correlation of outflow forces of intermediate mass protostars with the luminosity. The aim of this paper is to derive outflow forces from outflows of six intermediate mass protostellar regions and validate the apparent correlation between total luminosity and outflow force seen in earlier work, as well as remove uncertainties caused by different methodology. By comparing CO 6--5 observations obtained with APEX with non-LTE radiative transfer model predictions, optical depths, temperatures, densities of the gas of the molecular outflows are derived. Outflow forces, dynamical timescales and kinetic luminosities are subsequently calculated. Outflow parameters, including the forces, were derived for all sources. Temperatures in excess of 50 K were found for all flows, in line with recent low-mass results. However, comparison with other studies could not corroborate conclusions from earlier work on intermediate mass protostars which hypothesized that fragmentation enhances outflow forces in clustered intermediate mass star formation. Any enhancement in comparison with the classical relation between outflow force and luminosity can be attributed the use of a higher excitation line and improvement in methods; They are in line with results from low-mass protostars using similar techniques. The role of fragmentation on outflows is an important ingredient to understand clustered star formation and the link between low and high-mass star formation. However, detailed information on spatial scales of a few 100 AU, covering all individual members is needed to make the necessary progress.
description: 14 pages, accepted for publication in A&A; changed a few boldface text left in
Cardiovascular health and the modifiable burden of incident myocardial infarction: the Tromsø Study
Creators: name: Loehr, Laura
name: Heiss, Gerardo
name: Wilsgaard, Tom
Publisher: name: BioMed Central
Year: 2015

description: Abstract Background The American Heart Association has proposed an impact goal for the year 2020 to improve cardiovascular health by 20%. The objectives of the study were to assess the association between the proposed cardiovascular health metric score and incident myocardial infarction (MI) and to estimate the generalized impact fraction (GIF). Methods The health metric score was derived from ideal levels of six cardiovascular risk factors from the population-based Tromsø Study of 22,121 residents of Tromsø, Norway aged 30 to 79 years, examined in 1994–95, 2001, and 2007–08. Incident events of MI were recorded from the date of enrollment in 1994–95 to the end of 2010. Adjudication of hospitalized and out-of hospital events was performed by an independent endpoints committee based on data from hospital and out-of hospital journals, autopsy records and death certificates. Cox proportional hazard regression was used to estimate hazard ratios (HR). GIF was calculated from age stratified analysis using a case-load weighted-sum method. Bootstrapping was used to estimate 95% simulation intervals. Results A total of 1652 MIs accrued over an average of 14.7 person-years of follow-up. Few men (0.96%) and women (3.6%) had ideal levels in all 6 metrics. 64.7% (men) and 55.7% (women) had ideal levels in 2 or 3 metrics. The age-adjusted HR per point increase in health score was 0.65 (95% confidence interval: 0.61, 0.70) in men and 0.59 (0.54, 0.64) in women. A shift of 30% of subjects from low score levels ≤3 to scores ≥4 was estimated to prevent 13.7% (11.2, 16.2) of incident MI in men and 15.9% (12.1, 19.4) in women. Conclusions The association between the health metric score and MI indicate that close to 15% of incident MIs could be prevented by attainable and realistic improvements in the health metrics.
title: Beyond the complex statistical analysis; will Diffusion Tensor Imaging and Fiber Tractography be simply helpful to diagnosis for radiologist?
Creators: name: Yildirim, Duzgun
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Neuroradiology brain
subject: Neuroradiology brain
subject: Neural networks
subject: Technical aspects
subject: Education and training

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Thanks to fast developing technology, visualization of fiber tracts at brain is possible. The capability of diffusion tensor imaging to reliably display secondary alterations of the white matter tracts caused by the primary pathology has the...