cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Раскопки летописной Ушицы
Creators: name: Моця, Олександр
name: Kuchera, Mykhailo
name: Горішній П.А.
Publisher: name: Figshare
Year: 2019
Subjects: Archaeology

description: Раскопки летописной Ушицы // Археологические открытия 1976 г. - М.: Наука, 1977 / Співавт.: Кучера М.П., Горішній П.А. - С.320-321
A List of Bright Interferometric Calibrators measured at the ESO VLTI
Creators: name: Richichi, A.
name: Percheron, I.
name: Davis, J.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: In a previous publication (Richichi & Percheron 2005) we described a program of observations of candidate calibrator stars at the ESO Very Large Telescope Interferometer (VLTI), and presented the main results from a statistical point of view. In the present paper, we concentrate on establishing a new homogeneous group of bright interferometric calibrators, based entirely on publicly available K-band VLTI observations carried out with the VINCI instrument up to July 2004. For this, we have defined a number of selection criteria for the quality and volume of the observations, and we have accordingly selected a list of 17 primary and 47 secondary calibrators. We have developed an approach to a robust global fit for the angular diameters using the whole volume of quality-controlled data, largely independent of a priori assumptions. Our results have been compared with direct measurements, and indirect estimates based on spectrophotometric methods, and general agreement is found within the combined uncertainties. The stars in our list cover the range K=-2.9 to +3.0 mag in brightness, and 1.3 to 20.5 milliarcseconds in uniform-disk diameter. The relative accuracy of the angular diameter values is on average 0.4% and 2% for the primary and secondary calibrators respectively. Our calibrators are well suited for interferometric observations in the near-infrared on baselines between ~20m and ~200m, and their accuracy is superior, at least for the primary calibrators, to other similar catalogues. Therefore, the present list of calibrators has the potential to lead to significantly improved interferometric scientific results.
Single production of the top partners at high energy colliders
Creators: name: Yue, Chong-Xing
name: Yang, Hui-Di
name: Ma, Wei
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The left-right twin $Higgs$ ($LRTH$) model is a concrete realization of the twin $Higgs$ mechanism, which predicts the existence of the top partner $T$. In this paper, we consider production of $T$ associated with the top quark $t$ at the high energy linear $e^{+}e^{-}$ collider ($ILC$) and the $LHC$ experiments, and its single production in future linac-ring type $ep$ collider experiment. To compare our results with those of the littlest $Higgs$ model with $T$-parity, we also estimate production of the $T$-even top partner $T_{+}$ via the corresponding processes in these high energy collider experiments. A simply phenomenological analysis is also given.
description: 21 pages, 10 figures; to be published in Nucl. Phys. B
The Nonvanishing problem for varieties with nef anticanonical bundle
Creators: name: Lazić, Vladimir
name: Matsumura, Shin-ichi
name: Peternell, Thomas
name: Tsakanikas, Nikolaos
name: Xie, Zhixin
Publisher: name: arXiv
Year: 2022
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14E30

description: We prove that if $(X,Δ)$ is a threefold pair with mild singularities such that ${-}(K_X+Δ)$ is nef, then the numerical class of ${-}(K_X+Δ)$ is effective.
description: v4: minor changes; to appear in Doc. Math
Additional file 10 of Tumor-suppressive circRHOBTB3 is excreted out of cells via exosome to sustain colorectal cancer cell fitness
Creators: name: Chen, Chaoyi
name: Yu, Hongfei
name: Han, Fengyan
name: Lai, Xuan
name: Ye, Kehong
name: Lei, Siqin
name: Mai, Minglang
name: Lai, Maode
name: Zhang, Honghe
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer
subject: 60506 Virology
subject: Computational Biology

description: Additional file 10: Table S1. Oligonucleotide sequences used in this study. Table S2. Vectors used in this study. Table S3. Antibodies used in this study.
Passive Artificial Magnetic Conductor (AMC) Reflector for Far-Field Beam Steering
Creators: name: Al Nahiyan, Swad
name: Ramzan, Mehrab
name: Kamal, Shahanawaz
name: Sen, Padmanava
Publisher: name: Zenodo
Year: 2024

description: This paper presents a 21×21 passive artificial magnetic conductor (PAMC) surface aimed at achieving fixed beam steering of +30◦ at 10 GHz, featuring a measured beam steering bandwidth ranging from 9.75 GHz to 10.75 GHz. By optimizing its placement relative to the wave source, the PAMC facilitates an additional 60◦ of beam steering in both the azimuth and elevation planes. A notable feature that distinguishes the proposed PAMC from the existing AMC surfaces in the literature is its simplified structure, which was achieved by modifications solely in the geometry of the unit cells. Applications of the PAMC span various domains, including millimeter-wave massive multiple-input−multiple-output (MIMO) systems, future radars as well as wireless communication and networking paradigms. Through simulation, detailed analysis and PAMC measurements, the paper highlights the efficacy and potential of the proposed PAMC surface.
Extraction of ground-state decay constant from dispersive sum rules: QCD vs potential models
Creators: name: Lucha, Wolfgang
name: Melikhov, Dmitri
name: Simula, Silvano
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We compare the extraction of the ground-state decay constant from the two-point correlator in QCD and in potential models and show that the results obtained at each step of the extraction procedure follow a very similar pattern. We prove that allowing for a Borel-parameter-dependent effective continuum threshold yields two essential improvements compared to employing a Borel-parameter-independent quantity: (i) It reduces considerably the (unphysical) dependence of the extracted bound-state mass and the decay constant on the Borel parameter. (ii) In a potential model, where the actual value of the decay constant is known from the Schroedinger equation, a Borel-parameter-dependent threshold leads to an improvement of the accuracy of the extraction procedure. Our findings suggest that in QCD a Borel-parameter dependent threshold leads to a more reliable and accurate determination of bound-state characteristics by the method of sum rules.
description: 7 pages
title: Ð¡Ð¿Ð¾ÑÑ, ÑÐµÐ»Ð¾Ð²ÐµÐº, Ð·Ð´Ð¾ÑÐ¾Ð²ÑÐµ. XI ÐÐµÐ¶Ð´ÑÐ½Ð°ÑÐ¾Ð´Ð½ÑÐ¹ ÐºÐ¾Ð½Ð³ÑÐµÑÑ, 26â28 Ð°Ð¿ÑÐµÐ»Ñ 2023 Ð³Ð¾Ð´Ð°, Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³, Ð Ð¾ÑÑÐ¸Ñ
title: Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ñ ÐºÐ¾Ð½Ð³ÑÐµÑÑÐ°
titleType: Subtitle
title: Sport, people and health
Creators: name: "Ð¡Ð¿Ð¾ÑÑ, ÑÐµÐ»Ð¾Ð²ÐµÐº, Ð·Ð´Ð¾ÑÐ¾Ð²ÑÐµ", Ð¼ÐµÐ¶Ð´ÑÐ½Ð°ÑÐ¾Ð´Ð½ÑÐ¹ Ð½Ð°ÑÑÐ½ÑÐ¹ ÐºÐ¾Ð½Ð³ÑÐµÑÑ
Publisher: name: ÐÐÐÐÐ¢ÐÐ¥-ÐÐ ÐÐ¡Ð¡
Year: 2023
Subjects: ÑÐ¸Ð·Ð¸ÑÐµÑÐºÐ°Ñ ÐºÑÐ»ÑÑÑÑÐ°
ÑÐ¿Ð¾ÑÑ

description: ÐÐ°ÑÐµÑÐ¸Ð°Ð»Ñ ÐÐµÐ¶Ð´ÑÐ½Ð°ÑÐ¾Ð´Ð½Ð¾Ð³Ð¾ ÐÐ¾Ð½Ð³ÑÐµÑÑÐ° Â«Ð¡Ð¿Ð¾ÑÑ, Ð§ÐµÐ»Ð¾Ð²ÐµÐº, ÐÐ´Ð¾ÑÐ¾Ð²ÑÐµÂ» Ð¾ÑÐ²Ð°ÑÑÐ²Ð°ÑÑ ÑÐ¸ÑÐ¾ÐºÐ¸Ð¹ ÐºÑÑÐ³ Ð²Ð¾Ð¿ÑÐ¾ÑÐ¾Ð², ÑÐ²ÑÐ·Ð°Ð½Ð½ÑÑ Ñ Ð¿ÐµÑÑÐ¿ÐµÐºÑÐ¸Ð²Ð°Ð¼Ð¸ ÑÐºÑÐµÐ¿Ð»ÐµÐ½Ð¸Ñ Ð¸ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ Ð¼ÐµÐ¶Ð´ÑÐ½Ð°ÑÐ¾Ð´Ð½Ð¾Ð³Ð¾ ÑÐ¿Ð¾ÑÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð´Ð²Ð¸Ð¶ÐµÐ½Ð¸Ñ Ð² ÑÐ¾Ð²ÑÐµÐ¼ÐµÐ½Ð½Ð¾Ð¼ Ð¼Ð¸ÑÐµ Ð¸ Ñ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ½ÑÐ¼ ÑÐ°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ð¸ÐµÐ¼ Ð¿ÑÐ¾Ð±Ð»ÐµÐ¼ Ð² ÑÐ¾Ð²ÑÐµÐ¼ÐµÐ½Ð½Ð¾Ð¼ ÑÐ¿Ð¾ÑÑÐµ.
description: The proceedings of the Congress âSport, People and Healthâ cover a wide range of issues related to the prospects for strengthening and developing the International Sports Movement in the modern world and a comprehensive consideration of problems in modern sports.
Additional file 1 of Tumor-suppressive circRHOBTB3 is excreted out of cells via exosome to sustain colorectal cancer cell fitness
Creators: name: Chen, Chaoyi
name: Yu, Hongfei
name: Han, Fengyan
name: Lai, Xuan
name: Ye, Kehong
name: Lei, Siqin
name: Mai, Minglang
name: Lai, Maode
name: Zhang, Honghe
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer
subject: 60506 Virology
subject: Computational Biology

description: Additional file 1: Fig. S1. Analysis of expression and survival from the TCGA and GEO databases. (A) The reanalyzed GEO datasets in this study. (B) Kaplan-Meier survival analysis of CRC, PAAD, and HCC patients according to the expression level of RHOBTB3 from the TCGA. All experiments were repeated for three times, data were shown as mean ± SD, NS P > 0.05, in Student’s test or log-rank test.
Automatic Performance Estimation for Decentralized Optimization
Creators: name: Colla, Sebastien
name: Hendrickx, Julien M.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Optimization and Control (math.OC)
subject: Multiagent Systems (cs.MA)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences

description: We present a methodology to automatically compute worst-case performance bounds for a large class of first-order decentralized optimization algorithms. These algorithms aim at minimizing the average of local functions that are distributed across a network of agents. They typically combine local computations and consensus steps. Our methodology is based on the approach of Performance Estimation Problem (PEP), which allows computing the worst-case performance and a worst-case instance of first-order optimization algorithms by solving an SDP. We propose two ways of representing consensus steps in PEPs, which allow writing and solving PEPs for decentralized optimization. The first formulation is exact but specific to a given averaging matrix. The second formulation is a relaxation but provides guarantees valid over an entire class of averaging matrices, characterized by their spectral range. This formulation often allows recovering a posteriori the worst possible averaging matrix for the given algorithm. We apply our methodology to three different decentralized methods. For each of them, we obtain numerically tight worst-case performance bounds that significantly improve on the existing ones, as well as insights about the parameters tuning and the worst communication networks.
description: 15 pages, 7 figures, accepted for publication in IEEE Transactions on Automatic Control. arXiv admin note: text overlap with arXiv:2103.14396
Deuteron stripping and pickup involving halo nuclei 11Be and 15C
Creators: name: Deltuva, A.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Three-body calculations of (d,p) and (p,d) reactions involving one-neutron halo nuclei 11Be and 15C are performed using the framework of Faddeev-type scattering equations. Important effects of the optical potential nonlocality are found improving the description of the experimental data. The obtained values for the neutron spectroscopic factor are consistent with estimations from other approaches.
description: 6 pages, 7 figures, extended version to be published in Phys. Rev. C
The Gaia Astrometric Survey
Creators: name: Sozzetti, A.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: In its all-sky survey, the ESA global astrometry mission Gaia will perform high-precision astrometry and photometry for 1 billion stars down to $V = 20$ mag. The data collected in the Gaia catalogue, to be published by the end of the next decade, will likely revolutionize our understanding of many aspects of stellar and Galactic astrophysics. One of the relevant areas in which the Gaia observations will have great impact is the astrophysics of planetary systems. This summary focuses on a) the complex technical problems related to and challenges inherent in correctly modelling the signals of planetary systems present in measurements collected with a space-borne observatory poised to carry out precision astrometry at the micro-arcsecond ($μ$as) level, and b) on the potential of Gaia $μ$as astrometry for important contributions to the astrophysics of planetary systems.
description: 2 pages. Summary of an invited talk given at Special Session 6 (Planetary Systems as Potential Sites for Life) of the XXVIIth IAU General Assembly held in Rio de Janeiro (Brazil). To appear in IAU Highlights of Astronomy 15 (2010)
Deep Learning for Effective and Efficient Reduction of Large Adaptation Spaces in Self-Adaptive Systems
Creators: name: Weyns, Danny
name: Gheibi, Omid
name: Quin, Federico
name: Van Der Donckt, Jeroen
Publisher: name: arXiv
Year: 2022
Subjects: subject: Software Engineering (cs.SE)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Many software systems today face uncertain operating conditions, such as sudden changes in the availability of resources or unexpected user behavior. Without proper mitigation these uncertainties can jeopardize the system goals. Self-adaptation is a common approach to tackle such uncertainties. When the system goals may be compromised, the self-adaptive system has to select the best adaptation option to reconfigure by analyzing the possible adaptation options, i.e., the adaptation space. Yet, analyzing large adaptation spaces using rigorous methods can be resource- and time-consuming, or even be infeasible. One approach to tackle this problem is by using online machine learning to reduce adaptation spaces. However, existing approaches require domain expertise to perform feature engineering to define the learner, and support online adaptation space reduction only for specific goals. To tackle these limitations, we present 'Deep Learning for Adaptation Space Reduction Plus' -- DLASeR+ in short. DLASeR+ offers an extendable learning framework for online adaptation space reduction that does not require feature engineering, while supporting three common types of adaptation goals: threshold, optimization, and set-point goals. We evaluate DLASeR+ on two instances of an Internet-of-Things application with increasing sizes of adaptation spaces for different combinations of adaptation goals. We compare DLASeR+ with a baseline that applies exhaustive analysis and two state-of-the-art approaches for adaptation space reduction that rely on learning. Results show that DLASeR+ is effective with a negligible effect on the realization of the adaptation goals compared to an exhaustive analysis approach, and supports three common types of adaptation goals beyond the state-of-the-art approaches.
description: 41 pages
Additional file 2 of Tumor-suppressive circRHOBTB3 is excreted out of cells via exosome to sustain colorectal cancer cell fitness
Creators: name: Chen, Chaoyi
name: Yu, Hongfei
name: Han, Fengyan
name: Lai, Xuan
name: Ye, Kehong
name: Lei, Siqin
name: Mai, Minglang
name: Lai, Maode
name: Zhang, Honghe
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer
subject: 60506 Virology
subject: Computational Biology

description: Additional file 2: Fig. S2. Verification of exosomes. (A) Observation of exosomes by TEM. (B) Western blotting of CRC cell-derived exosomes using anti-CD63 and anti-TSG101 antibodies. Anti-calnexin was used as a negative control, and cellular lysates were used as positive loading controls.
Indian Education Resource Centre fonds inventory (revised edition)
Creators: name: Wodarczak, Erwin
Publisher: name: University of British Columbia Archives
Year: 2011

description: The Indian Education Resource Centre was established in Brock Hall on the UBC campus in 1970. It functioned as a resource centre for native education in British Columbia, visiting native schools, establishing native research and curriculum projects, producing a newsletter, disseminating information about native affairs and education, and serving as a lobby organization for Indian education in B.C. and across Canada. An association of professionals, para-professionals and members of the educational community, the Centre was funded by government grants and private donations. The Centre was closed in 1978.
A study of the interplay between ionized gas and star clusters in the central region of NGC 5253 with 2D spectroscopy
Creators: name: Monreal-Ibero, A.
name: Vilchez, J. M.
name: Walsh, J. R.
name: Munoz-Tunon, C.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: ABRIDGED: A detailed 2D study of the central region of NGC5253 has been performed to characterize the stellar and ionized gas structure as well as the extinction distribution, physical properties and kinematics of the ionized gas in the central ~210pc x 130pc. We utilized optical integral field spectroscopy (IFS) data obtained with FLAMES. A detailed extinction map for the ionized gas in NGC5253 shows that the largest extinction is associated with the prominent Giant HII region. There is an offset of ~0.5" between the peak of the optical continuum and the extinction peak in agreement with findings in the infrared. We found that stars suffer less extinction than gas by a factor of 0.33. The [SII]l6717/[SII]l6731 map shows an electron density (N_e) gradient declining from the peak of emission in Ha (790cm^-3) outwards, while the argon line ratio traces areas with $N_e~4200 - 6200cm^(-3). The area polluted with extra nitrogen, as deduced from the excess [NII]/Ha, extends up to distances of 3.3" (~60pc) from the maximum pollution, which is offset by ~1.5" from the peak of continuum emission. Wolf-Rayet features are distributed in an irregular pattern over a larger area (~100pc x 100pc) and associated with young stellar clusters. We measured He^+ abundances over most of the field of view and values of He^++/H^+
description: accepted in Astronomy & Astrophysics. 21 pages, 22 figures
MicroRNA pathways as new functional axes in cell fate determination
Creators: name: Fazi, Francesco
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2014

description: The identification of a series of non-coding RNA (ncRNA) families, with regulatory roles in several biological processes, represents one of the most relevant advances derived from transcriptome analysis. These ncRNAs are actively transcribed from the genome of many organisms. Among them microRNAs (miRNAs) are small regulatory, single-stranded, RNA molecules (19–25 nucleotides in length) that are generated in the nucleus as hairpin primary transcripts. miRNAs processing is carried out initially in the nucleus and later on in the cytoplasm, where the mature miRNAs molecules, through a limited base-pairing complementarity, destabilize or block the translation of their phylogenetically conserved target transcripts [1]. miRNAs exert their function assembled in the RNA-induced silencing complexes (RISCs), where members of Argonaute (Ago) family of proteins provide a unique platform for target recognition and gene silencing. Interestingly, recent evidences also suggest that miRNAs and epigenetic pathways appear to form a complex regulatory circuit that modulates the expression of an increasing number of genes in the genome. miRNAs are not only modulated by epigenetic regulation but it is now emerging that miRNAs also have specific epigenetic functions for the regulation of the transcriptional landscape of the cell. Following the identification of a functional miRNAs pathway in C. elegans, their contribution to both embryonic development and maintenance of tissue homeostasis in adults has rapidly emerged also in mammals. miRNAs exhibit a developmental stage- and tissue-specific expression and are present in critical regulatory pathways to regulate stem cells function, cell lineage specification/differentiation, maintenance of cell identity and tissue induction, growth and morphogenesis. The identification of the molecular pathways involving miRNAs and specific RNA-binding proteins, responsible for the regulation of their production, localization, stability and activity, is gaining crucial importance for the characterization of physiological and pathological processes of human development.
description: Italian Journal of Anatomy and Embryology, Vol 118, No 2 (Supplement) 2013
Expression of the K-Cl co-transporter KCC2 in cerebral cortex and thalamus during murine postnatal development
Creators: name: Amadeo, Alida
name: Ferrari, Marco
name: Aracri, Patrizia
name: Pasini, Maria Enrica
name: Smondel, Sara
name: Becchetti, Andrea
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2014

description: In the adult central nervous system GABA mediates fast inhibitory transmission, whereas during development it is an excitatory transmitter and a trophic factor involved in controlling morphogenesis (Ben-Ari, 2002). This funcional shift occurs as a result of a progressively increasing expression of the KCC2 cotransporter, the major chloride extruder in mature neurons. In several pathological conditions associated with hyperexcitability, such as epilepsy, suppression of KCC2 may contribute to alter the balance of excitation and inhibition (Chamma et al., 2012), especially during neural circuit formation. On these basis we studied the expression of KCC2 in two representative areas of neocortex, somatosensory and prefrontal (PFC), and in the dorsal thalamus, at different postnatal stages by western blot and immunocytochemical analysis. Our results show conspicuous expression of KCC2 at postnatal day 0 (P0) in the neuropil of thalamic nuclei, except the reticular nucleus. Lower expression is observed in cortical areas, with PFC displaying the lowest signal. In the first postnatal week, KCC2 is mainly localized in the cell bodies of cortical GABAergic neurons and pyramidal cells. After P7, it is gradually distributed in the membranes of the whole somatodendritic compartment, becoming prevalent in the neuropil by P14. In the adult cortices an intense labelling for KCC2 is observed in the supragranular layers if compared with the moderate expression of layer V; in the thalamus the anterior and sensory nuclear groups show the highest immunoreactivity. Overall, our results suggest a complex spatiotemporal pattern of KCC2 expression in the murine prosencephalon that needs to be related not only with inhibitory transmission but also with the different arrangements of neuronal circuits in cortical and thalamic subregions.
description: Italian Journal of Anatomy and Embryology, Vol 118, No 2 (Supplement) 2013
Stress granules induced by oxidative stress in cultured fibroblast from TDP-43 mutant ALS patients
Creators: name: Brancia, Carla
name: Coni, Paola
name: Floris, Andrea
name: Bellini, Ilaria
name: Orrù, Sandro
name: Sogos, Valeria
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2014

description: Stress granules (SGs) are transient cytoplasmic aggregates that rapidly form when cells are exposed to stress and consist of large messenger ribonucleoprotein (mRNPs) complexes. The SGs seem to function as storage depots for translation silenced complex and are implicated in stress-induced inhibition of global protein synthesis. Protein aggregation, has been observed in several neurodegenerative diseases, including Amyotrophic Lateral Sclerosis (ALS). The protein TDP-43 (TAR DNA-Binding Protein-43), encoded by one of the ALS-causative gene (TARDBP), is a major constituent of pathological inclusions in this disease and it is seems to be implicated in the regulation of SGs. Therefore we investigated the different characteristics of SGs in human cultured fibroblasts from ALS patients carrying TARDBPA382T mutation (group 1) versus healthy subjects (group 2). The cells were exposed to stressful conditions using sodium arsenite (SA) at different concentrations (0.5 mM, 1 mM) and exposure times (30 min, 1h). Preliminary results showed, after 30 minutes, small and sporadic cytoplasmic inclusions immunostained for TIA-1(T-cell internal antigen-1), an early marker for SGs, in both groups of cells. After 1h, the TIA-1 immunostained granules were bright, copious and scattered into the cytosol. Interestingly, we observed a significantly higher number of cells exhibiting SGs in fibroblasts from healthy controls (66%) compared to ALS patients (34%). In parallel, we identified the RNA binding protein HuR-1 (Human antigen R) in a fraction of Tia-1 positive SGs, as well as TDP- 43 localized into the nucleus of all the cells. These data raise the possibility that TDP-43 may modulate the stress granule formation, contributing to the cellular response to acute stress. Moreover the TDP-43 may regulate gene expression as well as cellular recovery and survival, and consequently its mutation may contribute to the neurodegeneration.
description: Italian Journal of Anatomy and Embryology, Vol 118, No 2 (Supplement) 2013
Toll-like receptor-4 is involved in hepatic fibrogenesis in the course of non-alcoholic fatty liver disease
Creators: name: Carotti, Simone
name: Vespasiani-Gentilucci, Umberto
name: Onetti-Muda, Andrea
name: Perrone, Giuseppe
name: Picardi, Antonio
name: Morini, Sergio
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2014

description: Toll-like receptor-4 (TLR4) is actively involved in liver in the response to injury from a variety of etiologies. Recently TLR4 expression by hepatic progenitor cells (HPC) and biliary epithelial cells has been associated to the progression of liver damage in chronic HCV-related hepatitis (1). HPC compartment activation in ductular reaction (DR) is a feature of progressive disease also in non-alcoholic fatty liver disease (NAFLD) (2). We aimed to investigate the association among TLR4 expression, HPC compartment activation and histopathologic features of fibrotic disease progression in NAFLD. Seventy-four patients who had undergone liver biopsy were included and immunohistochemistry for TLR4 was performed on hepatic tissue samples. CK-7 was used to evaluate HPC, bile ducts (BD)/ductules of DR and intermediate hepatocytes; α-smooth muscle actin was used to quantify the activation of hepatic stellate cells (HSC) and of portal/septal myofibroblasts (MF). HPC in BD/DR were responsible for the highest TLR4 intensity of staining. TLR4-positive HPC and BD/ DR correlated with fibrosis (p<0.01 and p<0.05), activity of MF (p<0.001 and p<0.05) and HSC (p<0.001 and p<0.001), portal and interface chronic inflammation (p<0.01 and p=0.01). The present study indicates the activation of the TLR4 expressing HPC compartment as important determinant of the progressive liver damage in NAFLD. TLR4 stimulation could represent one of the mechanisms directly linking the activation of HPC to inflammation and fibrosis in NAFLD.
description: Italian Journal of Anatomy and Embryology, Vol 118, No 2 (Supplement) 2013
Multi-Component Imaging of the Fermi Gamma-ray Sky in the Spatio-spectral Domain
Creators: name: Platz, Lukas I.
name: Knollmüller, Jakob
name: Arras, Philipp
name: Frank, Philipp
name: Reinecke, Martin
name: Jüstel, Dominik
name: Enßlin, Torsten A.
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We perform two distinct spatio-spectral reconstructions of the gamma-ray sky in the range of 0.56-316 GeV based on Fermi Large Area Telescope (LAT) data. Both describe the sky brightness to be composed of a diffuse-emission and a point-source component. The first model requires minimal assumptions and provides a template-free reconstruction as a reference. It makes use of spatial and spectral correlations to distinguish between the different components. The second model is physics-informed and further differentiates between diffuse emission of hadronic and leptonic origin. For this, we assume parametric, but spatially varying energy spectra to distinguish between the processes and use thermal Galactic dust observations to indicate the preferred sites of hadronic interactions. To account for instrumental effects we model the point-spread, the energy dispersion, and the exposure of the telescope throughout the observation. The reconstruction problem is formulated as a Bayesian inference task, that is solved by variational inference. We show decompositions of the Gamma-ray flux into diffuse and point-like emissions, and of the diffuse emissions into multiple physically motivated components. The diffuse decomposition provides an unprecedented view of the Galactic leptonic diffuse emission. It shows the Fermi bubbles and their spectral variations in high fidelity and other areas exhibiting strong cosmic ray electron contents, such as a thick disk in the inner Galaxy and outflow regions. Furthermore, we report a hard spectrum gamma ray arc in the northern outer bubble co-spatial with the reported X-ray arc by the eROSITA collaboration. All our spatio-spectral sky reconstructions and their uncertainty quantification are publicly available.
description: Please see the journal version for a language-edited release of this manuscript (open-access): https://doi.org/10.1051/0004-6361/202243819
Additional file 3 of Tumor-suppressive circRHOBTB3 is excreted out of cells via exosome to sustain colorectal cancer cell fitness
Creators: name: Chen, Chaoyi
name: Yu, Hongfei
name: Han, Fengyan
name: Lai, Xuan
name: Ye, Kehong
name: Lei, Siqin
name: Mai, Minglang
name: Lai, Maode
name: Zhang, Honghe
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer
subject: 60506 Virology
subject: Computational Biology

description: Additional file 3: Fig. S3. circRHOBTB3 inhibits CRC cell proliferation, migration and invasion in vitro. (A) Overexpression of circRHOBTB3 via lentivirus vector transfection in HCT8 and DLD1 cells. (B) Cell proliferation of circRHOBTB3-OE HCT8 and DLD1 cells. (C) migration and invasion assays of circRHOBTB3-OE RKO, HCT116, HCT8 and DLD1 cells. The right column diagram shows the quantification analysis results. (D) Expression of RHOBTB3 in circRHOBTB3-OE RKO, HCT116, HCT8 and DLD1 cells. (E) Cell migration and invasion assay of circRHOBTB3-si RKO cells. The right column diagram shows the quantification analysis results. All experiments were repeated for three times, data were shown as mean ± SD (A, B, D) or mean ± SEM (C, E), * P 0.05, in Student’s test (A, B, D) or paired Student’s test (C, E).
Pseudogap in fermionic density of states in the BCS-BEC crossover of atomic Fermi gases
Creators: name: Tsuchiya, S.
name: Watanabe, R.
name: Ohashi, Y.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We study pseudogap behaviors of ultracold Fermi gases in the BCS-BEC crossover region. We calculate the density of states (DOS), as well as the single-particle spectral weight, above the superfluid transition temperature $T_{\rm c}$ including pairing fluctuations within a $T$-matrix approximation. We find that DOS exhibits a pseudogap structure in the BCS-BEC crossover region, which is most remarkable near the unitarity limit. We determine the pseudogap temperature $T^*$ at which the pseudogap structure in DOS disappears. We also introduce another temperature $T^{**}$ at which the BCS-like double-peak structure disappears in the spectral weight. While one finds $T^*>T^{**}$ in the BCS regime, $T^{**}$ becomes higher than $T^*$ in the crossover and BEC regime. We also determine the pseudogap region in the phase diagram in terms of temperature and pairing interaction.
description: 6 pages, 4 figures, Proceedings of QFS 2009
Additional file 4 of Tumor-suppressive circRHOBTB3 is excreted out of cells via exosome to sustain colorectal cancer cell fitness
Creators: name: Chen, Chaoyi
name: Yu, Hongfei
name: Han, Fengyan
name: Lai, Xuan
name: Ye, Kehong
name: Lei, Siqin
name: Mai, Minglang
name: Lai, Maode
name: Zhang, Honghe
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer
subject: 60506 Virology
subject: Computational Biology

description: Additional file 4: Fig. S4. circRHOBTB3 is secreted outside of tumor cells and suppresses CRC cells in vitro and in vivo. (A) siRNA design for circRHOBTB3. (B) Expression of RHOBTB3 in circRHOBTB3-KD SW480 cells treated with RfxCas13d-BSJ-gRNA. (C) Migration and invasion assays of circRHOBTB3 KD SW480 cells. (D) Images of the subcutaneous xenograft tumors. (E) Images of the liver distant metastasis model established by splenic injection of control (empty vector) and circRHOBTB3-OE HCT116 cells in nude mice (the red arrows indicate metastatic foci). Data were shown as mean ± SD (B), NS P > 0.05, in Student’s test (B).
Novel in vitro and in vivo data on the cellular localization of Hsp10 in smokers affected by COPD and in lung-derived cell lines exposed to cigarette smoke extract as stressor
Creators: name: Corrao, Simona
name: Anzalone, Rita
name: Lo Iacono, Melania
name: Farina, Felicia
name: Peri, Giovanni
name: Zummo, Giovanni
name: Di Stefano, Antonino
name: Brun, Paola
name: Balbi, Bruno
name: Conway De Macario, Everly
name: Macario, Alberto J.L.
name: Cappello, Francesco
name: La Rocca, Giampiero
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2014

description: Cigarette smoke is a potent stressor for the respiratory system, contributing to pathogenesis, for instance in chronic obstructive pulmonary disease (COPD), but its effects on the expression, function, and cellular localization of mitochondrial chaperonins are still largely unknown. We studied in vivo (airways biopsies) the localization of Hsp10 and Hsp60 in patients (smokers and non-smokers) affected by mild-moderate COPD, and characterized the effects of non-lethal doses of cigarette smoke extract (CSE) on the expression of these molecules in two human cell lines: lung fibroblasts (HFL-1) and bronchial epithelial (16HBE). We applied various in vitro methods: immunohistochemistry (IHC), subcellular fractionation analyses (SFA), Western blotting (WB), immunocytochemistry (ICC), and transmission electron microscopy (TEM) immunogold, and used bioinformatics and databases searches to gather structural in silico data for interpreting and complementing the in vitro results. IHC showed that in smokers and non-smokers COPD patients Hsp10 was localized in both, the cytoplasm and the nucleus of epithelial and lamina propria cells, while Hsp60 was present only in the cytosol. ICC, SFA, and WB on both CSE-exposed cell lines confirmed the presence of nuclear Hsp10, with an increasing trend in parallel to CSE concentration. TEM immunogold further confirmed Hsp10 in the nucleus, in addition to its presence in the cytoplasm and mitochondria, on both cell lines. Bioinformatics and in silico structural analyses indicated that Hsp10 can localize in extramitochondrial sites, such as the nucleus, even if Hsp10 lacks known DNA-binding motifs or nuclear import signals in its primary sequence. Our data suggest a link between exposure to exogenous oxidative stress and cell response, involving Hsp10, which would play roles different from its canonical functions. It is known that Hsp10 can display an array of functions depending on its location: cytoplasm, mitochondria, or extracellular. Here, we show for the first time the presence of Hsp10 in the nucleus of epithelial and stromal human-lung cell lines, paralleling the observations in vivo in COPD patients, and indicating that intranuclear Hsp10 levels are affected by oxidative stress due to an exogenous stressor like cigarette-smoke. The questions now are by what mechanism Hsp10 becomes a resident of the nucleus and what are its functions there.
description: Italian Journal of Anatomy and Embryology, Vol 118, No 2 (Supplement) 2013
Reconstructing the Traffic State by Fusion of Heterogeneous Data
Creators: name: Treiber, Martin
name: Kesting, Arne
name: Wilson, R. Eddie
Publisher: name: arXiv
Year: 2009
Subjects: subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: Popular Physics (physics.pop-ph)
subject: FOS: Physical sciences

description: We present an advanced interpolation method for estimating smooth spatiotemporal profiles for local highway traffic variables such as flow, speed and density. The method is based on stationary detector data as typically collected by traffic control centres, and may be augmented by floating car data or other traffic information. The resulting profiles display transitions between free and congested traffic in great detail, as well as fine structures such as stop-and-go waves. We establish the accuracy and robustness of the method and demonstrate three potential applications: 1. compensation for gaps in data caused by detector failure; 2. separation of noise from dynamic traffic information; and 3. the fusion of floating car data with stationary detector data.
description: For more information see http://www.mtreiber.de or http://www.akesting.de
Map of the sarcoglycan sub-complex in rat brain
Creators: name: Cutroneo, G.
name: Rizzo, G.
name: Di Mauro, D.
name: Speciale, F.
name: Vermiglio, G.
name: Favaloro, A.
name: Milazzo, C.
name: Buda, D.
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2014

description: The sarcoglycan-sub-complex is made up of six glycoproteins which play mechanosignaling functions, connecting the extracellular matrix to cytoskeleton. This protein complex has been identified in different kind of tissues; in central nervous system, instead, only the ζ-sarcoglycans and the ε-sarcoglycans are considered to be present, where they seem to play a different role from the role played in muscle. Although that, previous our study have shown the expression of the entire sarcoglycan sub-complex in some region of the rat brain and the colocalization of this complex with post-synaptic receptors as GABA and DOPA receptors. Since we found that each sarcoglycan changes in staining pattern level among the brain regions, in the present study we performed, for the first time, a map of sarcoglycans expression in whole brain of rat and we examined which kind of post-synaptic receptor colocalizes with sarcoglycans in each part of brain. Results have shown that in rat brain the staining pattern level for each sarcoglycan and the different kind of colocalization between sarcoglycans and post-synaptic receptors, sarcoglycan/GABA or sarcoglycan/ DOPA, are characteristic of each brain region. These results support a role of the sarcoglycan sub-complex in post-synaptic neurotransmission, maybe modulating post-synaptic receptor assembly and stabilization.
description: Italian Journal of Anatomy and Embryology, Vol 118, No 2 (Supplement) 2013
Suzaku X-Ray Imaging and Spectroscopy of Cassiopeia A
Creators: name: Maeda, Y.
name: Uchiyama, Y.
name: Bamba, A.
name: Kosugi, H.
name: Tsunemi, H.
name: Helder, E. A.
name: Vink, J.
name: Kodaka, N.
name: Terada, Y.
name: Fukazawa, Y.
name: Hiraga, J.
name: Hughes, J. P.
name: Kokubun, M.
name: Kouzu, T.
name: Matsumoto, H.
name: Miyata, E.
name: Nakamura, R.
name: Okada, S.
name: Someya, K.
name: Tamagawa, T.
name: Tamura, K.
name: Totsuka, K.
name: Tsuboi, Y.
name: Ezoe, Y.
name: Holt, S. S.
name: Ishida, M.
name: Kamae, T.
name: Petre, R.
name: Takahashi, T.
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Suzaku X-ray observations of a young supernova remnant, Cassiopeia A, were carried out. K-shell transition lines from highly ionized ions of various elements were detected, including Chromium (Cr-Kalpha at 5.61 keV). The X-ray continuum spectra were modeled in the 3.4--40 keV band, summed over the entire remnant, and were fitted with a simplest combination of the thermal bremsstrahlung and the non-thermal cut-off power-law models. The spectral fits with this assumption indicate that the continuum emission is likely to be dominated by the non-thermal emission with a cut-off energy at > 1 keV. The thermal-to-nonthermal fraction of the continuum flux in the 4-10 keV band is best estimated as ~0.1. Non-thermal-dominated continuum images in the 4--14 keV band were made. The peak of the non-thermal X-rays appears at the western part. The peak position of the TeV gamma-rays measured with HEGRA and MAGIC is also shifted at the western part with the 1-sigma confidence. Since the location of the X-ray continuum emission was known to be presumably identified with the reverse shock region, the possible keV-TeV correlations give a hint that the accelerated multi-TeV hadrons in Cassiopeia A are dominated by heavy elements in the reverse shock region.
description: Publ. Astron. Soc. Japan 61, pp.1217-1228 (2009)
VGF and Type II Diabetes: decrease of VGF fragment levels in adipose tissues of diet-induced obese mice
Creators: name: D’Amato, Filomena
name: Cocco, Cristina
name: Noli, Barbara
name: Pilleri, Roberta
name: Ferri, Gian-Luca
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2014

description: VGF encodes a precursor protein processed in various neuropeptides, one of these involved in metabolic mechanisms and named TLQP-21, stimulates the autonomic activation of adipose tissue and reduces the early phase of diet-induced obesity in mouse. In immunohistochemistry (ICC) and ELISA, we used antisera to short sequences at C-/N-terminus of the VGF precursor, and of several VGF-derived peptides. Plasma of type II diabetes (DMII) was taken from patients with different body mass index (BMI): (i) BMI =18-24, (ii) BMI=25-29, (iii) BMI=30-39, in parallel with samples from healthy subjects (iiii) matched with BMI of group “i” (n=10 samples/ group). Male CD1 mice were fed with standard chow (group-a: controls), or with standard chow plus 36% lard (group-b: obese) for 16 weeks (n=24 animals/group). For glucose tolerance test, 12 mice from groups a and b, respectively, received i.p. injection of glucose (3g/kg), and were sacrificed after 120 minutes. White and brown adipose tissues (WAT and BAT, respectively) were extracted (n=9 animals/group) while for ICC, mice (~4/group) were perfused with 4% paraformaldehyde. In plasma of DM II patients, we found a clear decrease of VGF C-t, in parallel with the increase of BMI (iiii=1200±70, i=1100±85, ii=760±60, iii=550±40 pmol/ml, mean±SEM). In WAT, through ELISA, we found a significant decrease for VGF C-t in group-b respect to group-a (2±0.5 vs. 5±2*, pmol/g, mean±SEM, *p<0.03). A similar trend was observed in BAT, not only for VGF C-t, but also for N-t, TLQP, and RVW peptides (groups b vs. a, respectively: 10±3 vs. 22±7**, 9±3 vs. 18±4**, 210±75 vs. 420±95**, and 38±11 vs. 70±10*, pmol/g, means±SEM, *p<0.007,**p<0.02). Moreover, exclusively in BAT of group-a but not of group-b, we measured a great increase of VGF C-t, N-t and RVW peptide levels after glucose load (values taken before and after glucose load, respectively: 22±7 vs 35±5**, 18±4 vs. 30±7 **and 70±10 vs. 95±10*, pmol/g, means±SEM, *p<0.02,**p<0.04). In pancreas, BAT and WAT tissues was showed an extended colocalization of VGF C-t peptides with sympathetic fibers, while TLQP peptides were largely restricted to noradrenergic perikaria in celiac ganglia of both control and obese mice. In conclusions, more than one VGF fragment could be important for peripheral activation of autonomic nervous system.
description: Italian Journal of Anatomy and Embryology, Vol 118, No 2 (Supplement) 2013
Minimal Flavor Violation and the Scale of Supersymmetry Breaking
Creators: name: Carena, M.
name: Menon, A.
name: Wagner, C. E. M.
Publisher: name: arXiv
Year: 2008
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this paper we explore the constraints from B-physics observables in SUSY models of Minimal Flavor Violation, in the large tan beta regime, for both low and high scale supersymmetry breaking scenarios. We find that the rare B-decays b -> s gamma and B_s -> mu+ mu- can be quite sensitive to the scale M at which supersymmetry breaking is communicated to the visible sector. In the case of high scale supersymmetry breaking, we show that the additional gluino contribution to the b -> s gamma and B_s -> mu+ mu- rare decay rates can be significant for large tan beta, mu and M_3. The constraints on B_u -> tau nu are relatively insensitive to the precise scale of M. We also consider the additional constraints from the present direct Higgs searches at the Tevatron in the inclusive H/A -> tau tau channel, and the latest CDMS direct dark matter detection experiments. We find that altogether the constraints from B-physics, Higgs physics and direct dark matter searches can be extremely powerful in probing regions of SUSY parameter space for low M_A and large tan beta, leading to a preference for models with a lightest CP-even Higgs mass close to the current experimental limit. We find interesting regions of parameter space that satisfy all constraints and can be probed by Higgs searches at the Tevatron and the LHC and by direct dark matter searches in the near future.
description: 24 pages, 6 figures. Added citations. Published in PRD