cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy
Creators: name: Soballe, Kjeld
name: Rubery, Paul T
name: Nakamura, Takashi
name: Zhang, Xinping
name: Carmouche, Jonathan
name: Boyce, Brendan F
name: O'Keefe, Regis J
name: Goater, J Jeffrey
name: Gromov, Kirill
name: Tiyapatanaputi, Prarop
name: Rabinowitz, Joseph
name: Schwarz, Edward M
name: Koefoed, Mette
name: Ito, Hiromu
name: Samulski, R Jude
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Structural allograft healing is limited because of a lack of vascularization and remodeling. To study this we developed a mouse model that recapitulates the clinical aspects of live autograft and processed allograft healing. Gene expression analyses showed that there is a substantial decrease in the genes encoding RANKL and VEGF during allograft healing. Loss-of-function studies showed that both factors are required for autograft healing. To determine whether addition of these signals could stimulate allograft vascularization and remodeling, we developed a new approach in which rAAV can be freeze-dried onto the cortical surface without losing infectivity. We show that combination rAAV-RANKL- and rAAV-VEGF-coated allografts show marked remodeling and vascularization, which leads to a new bone collar around the graft. In conclusion, we find that RANKL and VEGF are necessary and sufficient for efficient autograft remodeling and can be transferred using rAAV to revitalize structural allografts.
Eine unbekannte Trauermusik von Heinrich Schütz
Creators: name: Möller, Eberhard
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Dieser Artikel widmet sich einer unbekannten Trauermusik von Heinrich Schütz, dem sogenannten Trost-Lied, das Schütz anlässlich eines Todesfalls in der Familie des Hofbibliothekars Christian Behme schrieb. (Barbara Alge) Darauf bezugnehmend: Joshua Rifkin: Heinrich Schütz und Christian Brehme: Eine Ergänzung, in: SJb 34 (2012), S. 177-179.
description: Schütz-Jahrbuch, Bd. 33 (2011)
A role for leukocyte-endothelial adhesion mechanisms in epilepsy
Creators: name: McEver, Rodger P
name: Zanetti, Lara
name: Lowe, John B
name: Benati, Donatella
name: Xia, Lijun
name: Homeister, Jonathon W
name: Rossi, Barbara
name: Marzola, Pasquina
name: Ottoboni, Linda
name: Osculati, Antonio
name: Fabene, Paolo F
name: Merigo, Flavia
name: Nicolato, Elena
name: Butcher, Eugene C
name: Constantin, Gabriela
name: Sbarbati, Andrea
name: Mora, Graciela Navarro
name: Schio, Federica
name: Angiari, Stefano
name: Bach, Simona
name: Martinello, Marianna
name: Chakir, Asmaa
name: Osculati, Francesco
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The mechanisms involved in the pathogenesis of epilepsy, a chronic neurological disorder that affects approximately 1 percent of the world population, are not well understood1–3. Using a mouse model of epilepsy, we show that seizures induce elevated expression of vascular cell adhesion molecules and enhanced leukocyte rolling and arrest in brain vessels mediated by the leukocyte mucin P-selectin glycoprotein ligand-1 (PSGL-1) and leukocyte integrins α4β1 and αLβ2. Inhibition of leukocyte-vascular interactions either with blocking antibodies, or in mice genetically deficient in functional PSGL-1, dramatically reduced seizures. Treatment with blocking antibodies following acute seizures prevented the development of epilepsy. Neutrophil depletion also inhibited acute seizure induction and chronic spontaneous recurrent seizures. Blood-brain barrier (BBB) leakage, which is known to enhance neuronal excitability, was induced by acute seizure activity but was prevented by blockade of leukocyte-vascular adhesion, suggesting a pathogenetic link between leukocyte-vascular interactions, BBB damage and seizure generation. Consistent with potential leukocyte involvement in the human, leukocytes were more abundant in brains of epileptics than of controls. Our results suggest leukocyte-endothelial interaction as a potential target for the prevention and treatment of epilepsy.
The Super Patalan Numbers
Creators: name: Richardson, Thomas M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 5A10, 11B37, 11B75, 15A36

description: We introduce the super Patalan numbers, a generalization of the super Catalan numbers in the sense of Gessel, and prove a number of properties analagous to those of the super Catalan numbers. The super Patalan numbers generalize the super Catalan numbers similarly to how the Patalan numbers generalize the Catalan numbers.
Using non-photochemical quenching of chlorophyll a fluorescence to assess the light climate and growth rate of the cyanobacterium Anabaena circinalis
Creators: name: Green, Damian W
name: Oliver, Roderick L
Publisher: name: La Trobe
Year: 2023

description: La Trobe University Faculty of Science, Technology and Engineering Murray Darling Freshwater Research Centre

MDFRC item.

The possibility of using non-photochemical chlorophyll a fluorescence quenching analysis to indicate the prior light climate and to estimate the growth rate of A. circinalis cultures grown under a range of light regimes was examined. It was found that the degree of non-photochemical quenching measured following 9 - 12 h of darkness, qN (dark), was higher in cultures grown at a high total daily light dose (TDLD). This parameter was able to track large daily changes in TDLD, even in cultures exposed to diel light/dark cycles. The level of qN (dark) was influenced by changes to both the minimum (FO') and maximum (FM') levels of fluorescence. The relative change in FO' after dark incubation increased with growth irradiance, whereas the relative change in FM' after dark incubation saturated at moderate growth irradiances, showing a close relationship with cell growth. We observed that the relative change in FM' after dark incubation could distinguish between A. circinalis receiving the same TDLD but having different growth rates due to a difference in light regime. It is suggested that these fluorescence parameters may be suitable for estimating the TDLD and gross growth rate of A. circinalis in field environments, and therefore could be used to determine relative importance of light and loss factors in the formation and decline of cyanobacterial blooms.
Representation Analysis of Deep Reinforcement Learning algorithms in Robotic Environments
Creators: Taghian Jazi, Mehran
Publisher: name: University of Alberta Library
Year: 2022

The rise of Deep Learning (DL) and its assistance in learning complex feature representations significantly impacted Reinforcement Learning (RL). Deep Reinforcement Learning (DRL) made it possible to apply RL to complex real-world problems and even achieve human-level performance. One of these problems is related to robotics. Recently, DRL agents successfully learned optimal behavior in a range of robotic environments. The policy can provide much information from its learned representation. However, this policy is approximated using a neural network and, therefore, is a black box.

Explainable Artificial Intelligence (XAI) is a new AI subfield focusing on interpreting Machine Learning models' behavior. A large part of XAI's literature has emerged on feature relevance techniques to explain a deep neural network (DNN) output processing on images. These techniques have been extended to explain Graph classification tasks using Graph Networks (GN). Nevertheless, these methods haven't been exploited to analyze the DRL agent's behavior learned to perform in a robotic environment.

In this work, we proposed to analyze the representation learned by a DRL agent's policy in a robotic environment. We use graph structure to represent the robot's observation in an entity-relationship manner and graph neural networks as function approximators in DRL. For the interpretation phase, an explainability technique called Layer-wise Relevance Propagation (LRP), a feature relevance technique that had been successfully applied to explain image and graph classification tasks, is used to interpret the learned policy. We evaluate the information provided by the LRP on two simulated robotic environments on MuJoCo. The experiments and evaluation methods were delicately designed to effectively measure the value of knowledge gained by our approach to analyzing learned representations in the Deep Reinforcement Learning task.
Effectively integrating motivational interviewing skills into undergraduate nursing education
Creators: name: Lemon, Erin
Publisher: name: Oregon Health and Science University
Year: 2023
Subjects: subject: Motivational Interviewing
subject: Tobacco
subject: Students, Nursing
subject: Education, Nursing, Baccalaureate
subject: Curriculum
subject: Assessment of learning
subject: Skill building
subject: Clinical teaching

description: The proposed research study aims to explore the most effective methods of training undergraduate nursing students in motivational interviewing, such that they achieve a basic level of confidence in using MI skills by program completion. This study will compare the effectiveness of including an introductory training in MI skills alone versus adding a follow up training later in the program, as well as intentional integration into curriculum and clinical rotations throughout the nursing program, measuring both objective MI skill level and student perception of confidence in skills.
»Mein Schall aufs Ewig weist«: Das Jenseits und die Kirchenmusik in der lutherischen Orthodoxie
Creators: name: Küster, Konrad
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Ausgehend von Heinrich Schütz‘ Trauergedicht auf Heinrich Posthumus von Reuß und Johann Walters Gedicht Lob und Preis der löblichen Kunst Musica (1538) wird der Eindruck vermittelt, dass in der Lebenswelt des 17. Jahrhunderts die Vision vorherrschte, dass alle Christen nach ihrem Ableben im Jenseits zu Mittätigen im musikalischen Lobpreis Gottes würden. Anhand zeitgenössischer Dokumente der praktischen Theologie, also vor allem Predigten, mit denen eine eschatologische Idee an eine Gemeinde vermittelt wird, und kirchlichen Bildern wird der Frage nachgegangen, wie lange diese bei Walter aufscheinende Idee fortwirkte.
description: Schütz-Jahrbuch, Bd. 33 (2011)
Medien sozialer Distinktion: Funeral- und Gedenkkompositionen des 17. Jahrhunderts im europäischen Vergleich
Creators: name: Schmitz, Peter
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Dieser Beitrag diskutiert, inwiefern Begräbnis- und Memorialforschung auch für musikalische Zusammenhänge nutzbar gemacht werden kann. Der Autor stellt Funeral- und Gedenkkompositionen des 17. Jahrhunderts ins Zentrum seiner Überlegungen und befragt diese nach spezifischen Funktionalisierungsebenen. Dabei bemüht er sich um eine europäische konfessionsübergreifende Perspektive und geht konkret auf Werke mitteldeutscher, österreichischer und englischer Provenienz ein.
description: Schütz-Jahrbuch, Bd. 33 (2011)
Echos in und um »Daphne«
Creators: name: Varwig, Bettina
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Dieser Beitrag widmet sich dem verlorenen Notentext zu Heinrich Schütz‘ Pastoraldrama Dafne. Die Autorin geht von einem bestimmten Moment des Dramas aus, und zwar der Echoszene, die den ersten Akt eröffnet, und beleuchtet anhand dessen den kulturgeschichtlichen Ort des Werks innerhalb der europäischen Literaturszene jener Zeit.
description: Schütz-Jahrbuch, Bd. 33 (2011)
CCL3L1-CCR5 genotype influences durability of immune recovery during antiretroviral therapy of HIV-1–infected individuals
Creators: name: Deeks, Steven G
name: Agan, Brian K
name: Ahuja, Sunil K
name: Frost, Simon
name: Richman, Douglas
name: Little, Susan
name: Delmar, Judith
name: Ahuja, Seema S
name: Clark, Robert A
name: Kulkarni, Hemant
name: O'Connell, Robert J
name: Hecht, Frederick M
name: Dolan, Matthew J
name: Marconi, Vincent C
name: Martin, Jeffrey
name: Camargo, Jose F
name: He, Weijing
name: Catano, Gabriel
name: Eron, Joseph
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The basis for the extensive variability seen in the reconstitution of CD4+ T cell counts in HIV-infected individuals receiving highly active antiretroviral therapy (HAART) is not fully known. Here, we show that variations in CCL3L1 gene dose and CCR5 genotype, but not major histocompatibility complex HLA alleles, influence immune reconstitution, especially when HAART is initiated at <350 CD4+ T cells/mm3. The CCL3L1-CCR5 genotypes favoring CD4+ T cell recovery are similar to those that blunted CD4+ T cell depletion during the time before HAART became available (pre-HAART era), suggesting that a common CCL3L1-CCR5 genetic pathway regulates the balance between pathogenic and reparative processes from early in the disease course. Hence, CCL3L1-CCR5 variations influence HIV pathogenesis even in the presence of HAART and, therefore, may prospectively identify subjects in whom earlier initiation of therapy is more likely to mitigate immunologic failure despite viral suppression by HAART. Furthermore, as reconstitution of CD4+ cells during HAART is more sensitive to CCL3L1 dose than to CCR5 genotypes, CCL3L1 analogs might be efficacious in supporting immunological reconstitution.
Heinrich Schütz und Otto Gibel
Creators: name: Waczkat, Andreas
name: Erbe, Elisa
name: Evers, Timo
name: Richter, Rhea
name: Zur Nieden, Arne
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Dieser Beitrag kontextualisiert ein Zitat aus einem Brief, den Schütz am 29. Januar 1658 an den Mindener Kantor Otto Gibel gerichtet hat und in Gibels Propositiones Mathematico Musicae (1666) angeführt ist. Gibels Bildungsbiographie wird als Grundlage für die hohe Zahl von Referenzen nachgezeichnet, die Gibel in den Propositiones anführt. Die praktische Umsetzung der Propositiones in Gestalt der Konstruktion der „Chor-Pfeife“ mündet in der Frage, inwieweit die Verbindung von theoretischer Grundlegung und praktischer Umsetzung in ein Stimmungssystem die „neue Invention“ darstellt, von der Schütz schreibt.
description: Schütz-Jahrbuch, Bd. 33 (2011)
Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 production
Creators: name: Parmelee, Alissa
name: Doi, Kent
name: Robey, Pamela G
name: Brown, Jared M
name: Mezey, Éva
name: Leelahavanichkul, Asada
name: Star, Robert A
name: Hu, Xuzhen
name: Yuen, Peter S T
name: Jelinek, Ivett
name: Németh, Krisztián
name: Mayer, Balázs
name: Koller, Beverly H
name: Leelahavanichkul, Kantima
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Sepsis causes over 200,000 deaths yearly in the US; better treatments are urgently needed. Administering bone marrow stromal cells (BMSCs—also known as mesenchymal stem cells) to mice before or shortly after inducing sepsis by cecal ligation and puncture reduced mortality and improved organ function. The beneficial effect of BMSCs was eliminated by macrophage depletion or pretreatment with antibodies specific for interleukin-10 (IL-10) or IL-10 receptor. Monocytes and/or macrophages from septic lungs made more IL-10 when prepared from mice treated with BMSCs versus untreated mice. Lipopolysaccharide (LPS)-stimulated macrophages produced more IL-10 when cultured with BMSCs, but this effect was eliminated if the BMSCs lacked the genes encoding Toll-like receptor 4, myeloid differentiation primary response gene-88, tumor necrosis factor (TNF) receptor-1a or cyclooxygenase-2. Our results suggest that BMSCs (activated by LPS or TNF-α) reprogram macrophages by releasing prostaglandin E2 that acts on the macrophages through the prostaglandin EP2 and EP4 receptors. Because BMSCs have been successfully given to humans and can easily be cultured and might be used without human leukocyte antigen matching, we suggest that cultured, banked human BMSCs may be effective in treating sepsis in high-risk patient groups.
(:unas) unassigned
Creators: name: (:Unkn) Unknown
Publisher: name: Universita' degli Studi di Salerno
Year: 2024

description: Questo articolo pone l’attenzione sulla produzione scenografica di uno degli esponenti del Futurismo pugliese, sul quale ancora poco si è scritto: Oronzo Abbatecola. L’analisi del testo scritto dall’artista nel 1994, non noto alla critica italiana, Values in Art, e di alcuni libretti d’opera quali il Belfagor di Respighi e il Parsifal di Wagner, ha dato vita a un approfondimento su alcuni bozzetti che il pittore ha prodotto durante la sua lunga carriera. L’esame di alcuni scritti di Abbatecola, Marinetti e Prampolini, inoltre, ha rivelato coincidenze sorprendenti e scoperte originali utili alla ricerca.
description: The following article focuses on the set designing production of Oronzo Abbatecola, an exponent of Futurism in Apulia, about whom little has been written. The analysis of some pamphlets such as Belfagor by Respighi and Parsifal by Wagner and of Values in Art, a text written by the painter in 1994 and still unknown by Italian critics, has triggered a detailed study on some sketches drawn by the painter in his long career.. Furthermore, the examination of texts by Abbatecola, Marinetti and Prampolini revealed surprising coincidences and original discoveries.
CIB1 is a regulator of pathological cardiac hypertrophy
Creators: name: Xu, Jian
name: Molkentin, Jeffery D
name: Yuan, Weiping
name: Parise, Leslie V
name: Heineke, Joerg
name: Auger-Messier, Mannix
name: Drexler, Helmut
name: Correll, Robert N
name: Benard, Matthew J
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Hypertrophic heart disease is a leading health problem facing the Western world. Here we identified the small EF-hand domain-containing protein CIB1 (Ca2+ and integrin binding protein 1) in a screen for novel regulators of cardiomyocyte hypertrophy. Yeast two-hybrid screening for CIB1 interacting partners identified a related EF-hand domain-containing protein calcineurin B, the regulatory subunit of the pro-hypertrophic protein phosphatase calcineurin. CIB1 largely localizes to the sarcolemma in mouse and human myocardium, where it anchors calcineurin to control its activation in coordination with the L-type Ca2+ channel. CIB1 protein levels and membrane association were enhanced in cardiac pathological hypertrophy, but not in physiological hypertrophy. Consistent with these observations, mice lacking Cib1 show a dramatic reduction in myocardial hypertrophy, fibrosis, cardiac dysfunction, and calcineurin-NFAT activity following pressure overload, while the degree of physiologic hypertrophy after swimming was not altered. Transgenic mice with inducible and cardiac-specific overexpression of CIB1 showed enhanced cardiac hypertrophy in response to pressure overload or calcineurin signaling. Moreover, mice lacking the Ppp3cb gene showed no enhancement in cardiac hypertrophy associated with CIB1 overexpression. Thus, CIB1 functions as a novel regulator of cardiac hypertrophy through its ability to regulate calcineurin sarcolemmal association and activation.
D2.4 Report on barriers experienced by vulnerable groups
Creators: name: Ferri, Delia
name: Higgins, Noelle
name: Donnellan, Katie
name: Serra, M. Laura
Publisher: name: Zenodo
Year: 2022
Subjects: vulnerable groups
end users
access to culture
copyright law

description: The End-user perspective is an often-neglected aspect of the European Union (EU) copyright regulatory framework and of copyright scholarship. In light of the objectives pursued by reCreating Europe, and its overarching aim to promote a modern, creative, culturally diverse, accessible Europe, Work Package (WP) 2 discusses the role of End-users’ rights, interests, expectations, and behaviours vis-à-vis copyright rules. Within WP2, the aim of Task 2.2 is to assess the extent to which vulnerable groups experience barriers in accessing digital cultural content. It also aims to investigate whether, and to what extent, the EU regulatory framework might exacerbate or counteract those barriers. In that regard, we linked ex-ante the idea of vulnerability to structural inequalities by identifying specific groups of End-users. However, the analysis performed in this report aims to unveil further the role of those inequalities and specific barriers linked to them in accessing digital culture. Please note: a screen-reader accessible version of this report can be downloaded via this link https://docs.google.com/uc?export=download&id=1qek2QtRoAuFc570krWhUJH5YKdCKtNn4
LOSS OF JAK2 REGULATION VIA VHL-SOCS1 E3 UBIQUITIN HETEROCOMPLEX UNDERLIES CHUVASH POLYCYTHEMIA
Creators: name: Bunda, Severa
name: Ohh, Michael
name: Sufan, Roxana I
name: Simon, M Celeste
name: Boba, Lukasz M
name: Heathcote, Samuel A
name: Cheresh, David A
name: Chow, Vinca W K
name: Zhou, Bing
name: Barber, Dwayne L
name: Irwin, Meredith S
name: Sybingco, Stephanie S
name: Richmond, Terri D
name: Kim, William Y
name: Roche, Olga
name: Heir, Pardeep
name: Greer, Samantha N
name: Hickey, Michele M
name: Russell, Ryan C
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Chuvash polycythemia (CP) is a rare congenital form of polycythemia caused by homozygous R200W and H191D mutations in the von Hippel-Lindau (VHL) gene whose gene product is the principal negative regulator of hypoxia-inducible factor. However, the molecular mechanisms underlying some of the hallmark features of CP such as hypersensitivity to erythropoietin are unclear. Here, we show that VHL directly binds suppressor of cytokine signalling 1 (SOCS1) to form a heterodimeric E3 ligase that targets phosphorylated (p)JAK2 for ubiquitin-mediated destruction. In contrast, CP-associated VHL mutants have altered affinity for SOCS1 and fail to engage and degrade pJAK2. Systemic administration of a highly selective JAK2 inhibitor, TG101209, reverses the disease phenotype in vhlR200W/R200W knock-in mice, a model that faithfully recapitulates human CP. These results reveal VHL as a SOCS1-cooperative negative regulator of JAK2 and provide compelling biochemical and preclinical evidence for JAK2- targeted therapy in CP patients.
Developmental Contributions of Emotion Regulation and Joint Attention in the Emergence of Autism Spectrum Disorder
Creators: Raza, Sarah
Publisher: name: University of Alberta Library
Year: 2022

Current research efforts are focused on identifying the developmental pathways leading to the emergence of autism spectrum disorder (ASD). Prospective studies of infants at an increased likelihood of ASD report difficulties in emotional regulation (ER) and coordination of social attention (i.e., joint attention) among the earliest signs of ASD, appearing by 12 months of age. How these early-developing processes interact to predict ASD emergence is poorly understood. As such, multimodal, observational studies in infant siblings of children diagnosed with ASD are needed, as ascertainment of likelihood status does not depend on clinical ascertainment, thus an earlier developmental period can be examined. This dissertation examined the developmental relations between early ER and joint attention in infants who were at an increased likelihood (IL; have an older sibling with ASD) and low likelihood (LL; no family history of ASD) of an ASD diagnosis. Three areas were investigated: (1) the interrelations between early ER and social communication in typical development; (2) the relationship between behavioral affect and physiological arousal as measures of ER in IL and LL infants; and (3) how behavioral affect and physiological indices of ER can predict joint attention and ASD symptoms in IL and LL infants. IL and LL infants were assessed and compared at multiple time points during the first two years of life to track the development of ER and joint attention. Behavioral and physiological indices of ER were measured at 6, 12, and 18 months during an emotion-eliciting task called the Laboratory Temperament Assessment Battery. Joint attention was measured at 18 months using a modified version of the Early Social Communication Scales, and ASD symptoms were measured at 18 and 24 months. The results indicated that there was a relationship between ER and joint attention, as well as ER and ASD symptoms, among IL infants who were later classified with ASD. Moreover, joint attention was also related to ASD symptoms in both IL and LL infants. Taken together, the findings indicated that there is a developmental relationship between ER and joint attention during infancy, which in turn influences the emergence of ASD. That is, a complex interplay between emotion dysregulation and early deficits in joint attention may influence the emergence of ASD in IL infants. Results are discussed in relation to theoretical models on the developmental link between ER and social communication skills.
Publishing your (R) workflow: How to get started and where to go next
Creators: name: Figueiredo, Ludmilla
Publisher: name: Zenodo
Year: 2024
Subjects: NFDI4BiodiversityiDivSeasonalSchool2024
reproducibility

description: Presentation about how to make scientific code reproducible and how to publish it. Examples are focused on the use of the R language.
Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11
Creators: name: Prives, Carol
name: Mak, Tak Wah
name: Suzuki, Akira
name: Kamijo, Takehiko
name: Yamashita, Takayuki
name: Maehama, Tomohiko
name: Zhu, Yan
name: Kogo, Ryunosuke
name: Mimori, Koshi
name: Mori, Masaki
name: Wang, Jia
name: Nakano, Toru
name: Sasaki, Masato
name: Sasaki, Takehiko
name: Nishio, Miki
name: Itoh, Bunsho
name: Horie, Yasuo
name: Hikasa, Hiroki
name: Zhang, Yanping
name: Hamada, Koichi
name: Kawahara, Kohichi
name: Yang, Yong Ryoul
name: Komatsu, Yukako
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: PICT1 (also known as GLTSCR2) is considered a tumor suppressor because it stabilizes phosphatase and tensin homolog (PTEN), but individuals with oligodendrogliomas lacking chromosome 19q13, where PICT1 is located, have better prognoses than other oligodendroglioma patients. To clarify the function of PICT1, we generated Pict1-deficient mice and embryonic stem (ES) cells. Pict1 is a nucleolar protein essential for embryogenesis and ES cell survival. Even without DNA damage, Pict1 loss led to p53-dependent arrest of cell cycle phase G1 and apoptosis. Pict1-deficient cells accumulated p53, owing to impaired Mdm2 function. Pict1 binds Rpl11, and Rpl11 is released from nucleoli in the absence of Pict1. In Pict1-deficient cells, increased binding of Rpl11 to Mdm2 blocks Mdm2-mediated ubiquitination of p53. In human cancer, individuals whose tumors express less PICT1 have better prognoses. When PICT1 is depleted in tumor cells with intact P53 signaling, the cells grow more slowly and accumulate P53. Thus, PICT1 is a potent regulator of the MDM2-P53 pathway and promotes tumor progression by retaining RPL11 in the nucleolus
Heinrich Schütz as European cultural agent at the Danish courts
Creators: name: Moe, Bjarke
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Dieser Artikel beleuchtet Heinrich Schütz‘ Aktivitäten am dänischen Hof. Der Autor bezeichnet Schütz als „europäischen Kulturbotschafter“, der es verstand, dem dänischen Hof die „besten Komponisten Europas“ auf der Basis seiner eigenen internationalen Kontakte zu vermitteln.
description: Schütz-Jahrbuch, Bd. 33 (2011)
Evolution of an HIV glycan–dependent broadly neutralizing antibody epitope through immune escape
Creators: name: Hermanus, Tandile
name: Karim, Quarraisha Abdool
name: Lambson, Bronwen E
name: Moore, Penny L
name: Karim, Salim S Abdool
name: Wibmer, C Kurt
name: Tumba, Nancy L
name: Ping, Lihua
name: Sheward, Daniel J
name: Abrahams, Melissa-Rose
name: Ngandu, Nobubelo
name: Bajimaya, Shringkhala
name: Nonyane, Molati
name: Gray, Elin S
name: Bhiman, Jinal N
name: Seaman, Michael S
name: Morris, Lynn
name: Williamson, Carolyn
name: Swanstrom, Ronald I
name: Ranchobe, Nthabeleng
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Neutralizing antibodies are likely to play a crucial part in a preventative HIV-1 vaccine. Although efforts to elicit broadly cross-neutralizing (BCN) antibodies by vaccination have been unsuccessful1-3, a minority of individuals naturally develop these antibodies after many years of infection4-7. How such antibodies arise, and the role of viral evolution in shaping these responses, is unknown. Here we show, in two HIV-1–infected individuals who developed BCN antibodies targeting the glycan at Asn332 on the gp120 envelope, that this glycan was absent on the initial infecting virus. However, this BCN epitope evolved within 6 months, through immune escape from earlier strain-specific antibodies that resulted in a shift of a glycan to position 332. Both viruses that lacked the glycan at amino acid 332 were resistant to the Asn332-dependent BCN monoclonal antibody PGT128 (ref. 8), whereas escaped variants that acquired this glycan were sensitive. Analysis of large sequence and neutralization data sets showed the 332 glycan to be significantly underrepresented in transmitted subtype C viruses compared to chronic viruses, with the absence of this glycan corresponding with resistance to PGT128. These findings highlight the dynamic interplay between early antibodies and viral escape in driving the evolution of conserved BCN antibody epitopes.
Herzog Georg von Calenberg – barocker Staatschef und Dienstherr von Heinrich Schütz
Creators: name: Schwark, Thomas
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Die dynastischen Verhältnisse im Herrschaftsbereich Braunschweig-Lüneburg-Calenberg hatten einen nicht unbedeutenden und direkten Einfluss auf die Lebenswelt von Heinrich Schütz, der 1638 als Leiter der neugegründeten Hofkapelle nach Hannover berufen wurde. Deswegen soll neben dem System des frühmodernen Welfenstaates Schütz‘ Dienstherr und Auftraggeber Herzog Georg von Calenberg (1582–1641) in den Fokus genommen werden und ein vertiefter Blick auf die politischen und gesellschaftlichen Verhältnisse jener Zeit geworfen werden.
description: Schütz-Jahrbuch, Bd. 34 (2012)
Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity
Creators: name: Salter, Michael W
name: Tichauer, David
name: Woolf, Clifford J
name: Diatchenko, Luda
name: Trang, Tuan
name: Zheng, Ming
name: Herbert, Teri A
name: Zaykin, Dmitri V
name: Austin, Jean-Sebastien
name: Seltzer, Ze'ev
name: Meulen, Heather Vander
name: Yarkoni-Abitbul, Merav
name: Costigan, Michael
name: Ritchie, Jennifer
name: Livneh, Jessica
name: Gershon, Edith
name: Sorge, Robert E
name: Jordan, Joanne
name: Slade, Gary D
name: Beggs, Simon
name: Dorfman, Ruslan
name: Tan, Keith
name: Peltz, Gary
name: Smith, Shad B
name: John, Sally L
name: Maixner, William
name: Mogil, Jeffrey S
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Chronic pain is highly variable between individuals, as is the response to analgesics. Although much of the variability in chronic pain and analgesic response is heritable, an understanding of the genetic determinants underlying this variability is rudimentary1. Here we show that variation within the coding sequence of the gene encoding the P2X7 receptor (P2X7R) affects chronic pain sensitivity in both mice and humans. P2X7Rs, which are members of the family of ionotropic ATP-gated receptors, have two distinct modes of function: they can function through their intrinsic cationic channel or by forming nonselective pores that are permeable to molecules with a mass of up to 900 Da2,3. Using genome-wide linkage analyses, we discovered an association between nerve-injury–induced pain behavior (mechanical allodynia) and the P451L mutation of the mouse P2rx7 gene, such that mice in which P2X7Rs have impaired pore formation as a result of this mutation showed less allodynia than mice with the pore-forming P2rx7 allele. Administration of a peptide corresponding to the P2X7R C-terminal domain, which blocked pore formation but not cation channel activity, selectively reduced nerve injury and inflammatory allodynia only in mice with the pore-forming P2rx7 allele. Moreover, in two independent human chronic pain cohorts, a cohort with pain after mastectomy and a cohort with osteoarthritis, we observed a genetic association between lower pain intensity and the hypofunctional His270 (rs7958311) allele of P2RX7. Our findings suggest that selectively targeting P2X7R pore formation may be a new strategy for individualizing the treatment of chronic pain.
Memorandum of Agreement, Submitted to the Advisory Council on Historic Preservation, Demolition of Building 1030
Creators: name: Fort Sam Houston
Publisher: name: Fort Sam Houston
Year: 2000
Subjects: subject: JBSA-Sam Houston
valueUri: https://core.tdar.org/browse/geographic-keyword/82532/jbsa-sam-houston
subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Building 1030
valueUri: https://core.tdar.org/browse/other-keyword/150019/building-1030
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: An unsigned agreement regarding the Department of the Army, Fort Sam Houston and Advisory Council on Historic Preservation. The Department of the Army, Fort Sam Houston, has determined that an undertaking to demolish building 1030 will have an adverse effect on properties that are eligible for inclusion in the National Register of Historic Places, and has consulted with the Texas State Historic Preservation Officer, in accordance with Section 106 of the National Historic Preservation Act, 16 U.S.C. 470 (f), its implementing regulations (36 CFR Part 800), and the Programmatic Agreement executed September 19, 1997, among FSH, the SHPO, the Advisory Council on Historic Preservation, and interested persons.
Controle de Microorganismos na Recepção Hospitalar : Qual o Papel do Setor Administrativo?
Creators: name: Da Costa Xavier, Ana Beatriz
name: De Moura Lira, Ana Vitória
name: Assis, Caroline Nascimento
name: De Andrade, Delízia Pinheiro
name: Da Rosa Ventura, Desirê
name: Da Silva Gama, Maria Eduarda
name: Da Silva, Millena Albuquerque
Publisher: name: Zenodo
Year: 2023
Subjects: Enfermagem
Microrganismos
Bacteriologia

description: Fôlder sobre Controle de Microrganismos na Recepção Hospitalar, produzido pelas Graduandas de Enfermagem da Escola De Enfermagem Aurora de Afonso Costa - Universidade Federal Fluminense.
Heinrich Schütz als Oberkapellmeister »von Haus aus« am Wolfenbütteler Hof
Creators: name: Spohr, Arne
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Über mehr als zehn Jahre hinweg, von Ostern 1655 bis ca. 1666, war Heinrich Schütz als „Oberkapellmeister von Haus aus“ für den Wolfenbütteler Hof tätig, komponierte aber während dieser Zeit kein bekanntes Werk für seinen Dienstherrn und war nach bisherigem Kenntnisstand nur einmal in personam in der Stadt anwesend. Deswegen sollen andere Quellen nach Schütz‘ Rolle als „kulturell Handelndem“ und Kulturvermittler in dieser Zeit befragt werden und damit seine Verortung im Netzwerk der Wolfenbütteler kulturellen Akteure bestimmt werden.
description: Schütz-Jahrbuch, Bd. 34 (2012)
Generalized screened potential model
Creators: name: Gonzalez, P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: A new non relativistic quark model to calculate the spectrum of heavy quark mesons is developed. The model is based on an interquark potential interaction that implicitly incorporates screening effects from meson-meson configurations. An analysis of the bottomonium spectrum shows the appearance of extra states as compared to conventional non screened potential models.
description: 14 pages, 2 figures. arXiv admin note: substantial text overlap with arXiv:1301.2536
title: Jakob Hausheer 1865-1943
title: Jakob Hausheer, 1865-1943
titleType: AlternativeTitle
title: Abschiedsworte bei der Bestattung von D. Dr. phil. Jakob Hausheer, a. Professor an der Universität in Zürich
titleType: Subtitle
title: Montag, den 10. Mai 1943 im Krematorium in Zürich
titleType: Subtitle
Creators: name: Zimmermann, Karl
name: Gut, Walter
name: Ringger, Johannes
name: Baumgartner, Walter
Publisher: name: [Verlag nicht ermittelbar]
Year: 1943
Subjects: subject: 270 Geschichte des Christentums, Kirchengeschichte
subject: 490 Andere Sprachen
subject: 920 Biografien, Genealogie, Insignien
subject: Nachruf
subject: Hausheer, Jakob
subject: Wollishofen
subject: Zollikon
subject: Zürich

description: Inhalt: Abdankungs-Ansprache von Pfarrer Karl Zimmermann ; Ansprache von Herrn Professor Dr. W. Gut ; Ansprache von Herrn Pfarrer Johannes Ringger, Rifferswil ; Nachruf von Herrn Prof. Walter Baumgartner
Exact treatment of magnetism-driven ferroelectricity in the one-dimensional compass model
Creators: name: You, Wen-Long
name: Liu, Guang-Hua
name: Horsch, Peter
name: Oleś, Andrzej M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We consider a class of one-dimensional compass models with antisymmetric Dzyaloshinskii-Moriya exchange interaction in an external magnetic field. Based on the exact solution derived by means of Jordan-Wigner transformation, we study the excitation gap, spin correlations, ground-state degeneracy, and critical properties at phase transitions. The phase diagram at finite electric and magnetic field consists of three phases: ferromagnetic, canted antiferromagnetic, and chiral. Dzyaloshinskii-Moriya interaction induces an electrical polarization in the ground state of the chiral phase, where the nonlocal string order and special features of entanglement spectra arise, while strong chiral correlations emerge at finite temperature in the other phases and are controlled by a gap between the nonchiral ground state and the chiral excitations. We further show that the magnetoelectric effects in all phases disappear above a typical temperature corresponding to the total bandwidth of the effective fermionic model. To this end we explore the entropy, specific heat, magnetization, electric polarization, and the magnetoelectric tensor at finite temperature. We identify rather peculiar specific-heat and polarization behavior of the compass model which follows from highly frustrated interactions.
description: 15 pages, 15 figures, Slight change comparing with the published version
Das sozietäre Netzwerk der Herzogin Sophia Elisabeth von Braunschweig-Wolfenbüttel. »Die Fortbringende« – »Die Gutwillige« – »Die Befreiende«
Creators: name: Ball, Gabriele
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Herzogin Sophia Elisabeth von Braunschweig-Wolfenbüttel, als Komponistin in der Forschungsliteratur bereits präsent, wird anlässlich ihres 400. Geburtstages auf ihr kulturpolitisches und literarisches Wirken hin befragt und gewürdigt. Dazu wird besonders die Einbindung in ihr sozietäres Netzwerk untersucht und ihre Mitgliedschaft in zwei hochadeligen Damengesellschaften in den Vordergrund gerückt. Schließlich werden die Blütezeit der Zusammenarbeit mit der Fruchtbringenden Gesellschaft am Wolfenbütteler Hof und damit einhergehend die in dieser Zeit anzusiedelnden ersten persönlichen und brieflichen Kontakte mit Heinrich Schütz fokussiert.
description: Schütz-Jahrbuch, Bd. 34 (2012)
Temperature-driven band inversion in Pb$_{0.77}$Sn$_{0.23}$Se: Optical and Hall-effect studies
Creators: name: Anand, Naween
name: Chen, Zhiguo
name: Buvaev, Sanal
name: Choudhary, Kamal
name: Martin, C.
name: Gu, Genda
name: Sinnott, S. B.
name: Li, Zhiqiang
name: Hebard, A. F.
name: Tanner, D. B.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Optical and Hall-effect measurements have been performed on single crystals of Pb$_{0.77}$Sn$_{0.23}$Se, a IV-VI mixed chalcogenide. The temperature dependent (10--300 K) reflectance was measured over 40--7000 cm$^{-1}$ (5--870 meV) with an extension to 15,500 cm$^{-1}$ (1.92 eV) at room temperature. The reflectance was fit to the Drude-Lorentz model using a single Drude component and several Lorentz oscillators. The optical properties at the measured temperatures were estimated via Kramers-Kronig analysis as well as by the Drude-Lorentz fit. The carriers were p-type with the carrier density determined by Hall measurements. A signature of valence intraband transition is found in the low-energy optical spectra. It is found that the valence-conduction band transition energy as well as the free carrier effective mass reach minimum values at 100 K, suggesting temperature-driven band inversion in the material. Density function theory calculation for the electronic band structure also make similar predictions.
description: 10 pages, 15 figures
Vermischter Stil
Creators: name: Emans, Reinmar
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Ausgehend von zeitgenössischen Aussagen zur Entstehung des vermischten Stils aus italienischem und französischen Idiom und Beobachtungen zur Einbindung Agostino Steffanis in die Netzwerke der Welfenhöfe um Gottfried Wilhelm Leibniz wird die These aufgestellt, dass bislang die Bedeutung des Italieners Steffani für die Entwicklung des neuen musikalischen Stils unterschätzt wurde. Gleichzeitig folgt daraus, dass die weitere Anreicherung desselben mit Elementen des schwieriger zu fassenden deutschen Stils im Umfeld des Welfenhofs in der Konsequenz nicht zu überraschen vermag.
description: Schütz-Jahrbuch, Bd. 34 (2012)
Die Wolfenbütteler Anfänge der Sammlung Georg Österreich
Creators: name: Küster, Konrad
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Die Sammlungen Düben und Österreich bilden die Hauptquellen zu protestantischer Vokalmusik aus der 2. Hälfte des 17. Jahrhunderts. Ein kritischer und umfangreicher Neuzugang zu beiden Sammlungen ist jedoch unumgänglich, soll die Bedeutung derselben angemessen verstanden werden. Für die Wolfenbütteler Anfänge der Sammlung Georg Österreich wird als Beitrag zu diesem Desiderat eine erste Einordnung vorgenommen, verbunden mit dem Versuch einer chronologischen Gliederung, die auf Erkenntnissen der Schrift- und Wasserzeichenforschung beruht.
description: Schütz-Jahrbuch, Bd. 34 (2012)
Heinrich Schütz aus französischer Sicht – Vom Ende des 19. Jahrhunderts bis 1945
Creators: name: Rothmund, Elisabeth
Publisher: name: Schütz-Jahrbuch
Year: 2017

description: Die Vorzeichen der Rezeption der Werke von Heinrich Schütz in Frankreich waren – da barock, protestantisch und deutsch – einerseits schwierig, die drei genannten Aspekte bilden gleichzeitig allerdings auch bis heute die drei hauptsächlichen Zugangspunkte zum Oeuvre des Komponisten. Dem im ausgehenden 19. Jahrhundert zu verortenden Start der Schütz-Rezeption in Frankreich, der sich „national-spezifischer“ als spätere Phasen darstellt, wird im Folgenden bis zum Einschnitt der Beendigung des 2. Weltkrieges nachgegangen.
description: Schütz-Jahrbuch, Bd. 34 (2012)
Dyna with Options: Incorporating Temporal Abstraction into Planning
Creators: Mihucz, Gábor
Publisher: name: University of Alberta Library
Year: 2022

The motivation to incorporate planning, temporal abstraction and value function approximation in reinforcement learning (RL) algorithms is to reduce the amount of interaction with the environment needed to learn a near-optimal policy. Although each of these concepts has been under intense scrutiny for decades, less is known about their interplay, and specifically: under what circumstances does planning with options provide significant benefits over planning with only primitive actions or model-free alternatives? In this thesis we examine this question by endowing the background planning algorithm, Dyna with access to options with (near)-optimal option policies in two environments: a non-stationary tabular one, in which the changing reward function necessitates rapid value function updates, and in a deterministic, stationary, continuous-state environment that requires value function approximation, a setting in which planning with primitive actions is known to be suboptimal compared to model-free approaches. We find that in the non-stationary environment without a state visitation bonus, all planning algorithms perform significantly better than the model-free Q-learning algorithm; planning with only options (Dyno) performs better than planning with both actions and options (Dyna+options) or planning with actions only (Dyna), the latter two have comparable performance. When a state-visitation bonus is added, each algorithm performs similarly near-optimally, and satisfactory performance can be achieved by restricting the state visitation bonus to goal states. In the value function approximation realm, we find that Dyno outperforms DDQN in terms of speed and robustness at the beginning of learning, but later on, its performance degrades to that of DDQN's in the instances examined. Dyna+options performs better than Dyna and comparably to DDQN during much of the learning process but with higher variance and occasional dips. We conclude that having access to options with (near-)optimal option policies alone is not sufficient to combat the suboptimality arising from planning with inaccurate primitive models and argue that more sophisticated planning architectures are necessary that bypass the reliance on primitive models.
A Construction of MDS Quantum Convolutional Codes
Creators: name: Zhang, Guanghui
name: Chen, Bocong
name: Li, Liangchen
Publisher: name: arXiv
Year: 2014
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: In this paper, two new families of MDS quantum convolutional codes are constructed. The first one can be regarded as a generalization of \cite[Theorem 6.5]{GGGlinear}, in the sense that we do not assume that $q\equiv1\pmod{4}$. More specifically, we obtain two classes of MDS quantum convolutional codes with parameters: {\rm (i)}~ $[(q^2+1, q^2-4i+3,1;2,2i+2)]_q$, where $q\geq5$ is an odd prime power and $2\leq i\leq(q-1)/2$; {\rm (ii)}~ $[(\frac{q^2+1}{10},\frac{q^2+1}{10}-4i,1;2,2i+3)]_q$, where $q$ is an odd prime power with the form $q=10m+3$ or $10m+7$ ($m\geq2$), and $2\leq i\leq2m-1$.
description: 11 pages
The Role of Authentic Assessment Tasks in Problem-Based Learning
Creators: name: Koh, Kim
name: Delanoy, Nadia
name: Thomas, Christy
name: Bene, Rose
name: Chapman, Olive
name: Turner, Jeff
name: Danysk, Gail
name: Hone, Gabrielle
Publisher: name: Papers on Postsecondary Learning and Teaching
Year: 2019

description: Papers on Postsecondary Learning and Teaching, Vol. 3 (2019)