cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Interregional patient mobility in a decentralized healthcare system
Creators: name: Balia, Silvia
name: Brau, Rinaldo
name: Marrocu, Emanuela
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Sociology
subject: FOS: Sociology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy
subject: Hematology

description: Interregional patient mobility in a decentralized healthcare system. Regional Studies. Interregional patient mobility, measured as origin–destination patient flows between any two regions, is analysed within a dynamic spatial panel data framework using 2001–10 data on Italian hospital discharges. The aim is to assess the effects of the main determinants of patient flows, distinguishing between the impacts of regional health policies and those exerted by exogenous factors (geography, size, neighbouring regions, national policies). Empirical results indicate that the main drivers of mobility are regional income, hospital capacity, organizational structure, performance and technology. Moreover, neighbouring regions’ supply factors, specialization and performance largely affect mobility by generating significant local externalities.
A new sesquiterpene from the entomogenous fungus Phomopsis amygdali
Creators: name: Ma, Xiaoli
name: Wang, Wenshu
name: Gao, Fenghua
name: Li, Erwei
name: Guo, Liangdong
name: Pei, Yunfei
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Virology
subject: Plant Biology
subject: FOS: Biological sciences
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Pharmacology
subject: Microbiology
subject: Biochemistry

description: A new sesquiterpene, (+)-S-1-methyl-abscisic-6-acid (1), together with five known compounds, (+)-S-abscisic acid (2), fusicoccin J (3), 3α-hydroxyfusicoccin J (4), (R)-5-hydroxymethylmellein (5) and 4-hydroxyphenethyl acetate (6) was isolated from the fermentation extract of Phomopsis amygdali, an entomogenous fungus isolated from Call midge. Their structures were determined mainly by analysis of MS and NMR spectroscopic data. Compounds 1–6 were tested for antimicrobial activity against three plant pathogenic fungi: Gibberella zeae, Verticillium albo-atrum, and Fusarium nivale, and two bacteria: Escherichia coli and Pseudomonas aeruginosa 2033E. As a result, compounds 1–4 displayed antibacterial activity against Gram-negative P. aeruginosa 2033E, and the minimum inhibition concentration (MIC value) of 1–4 is 30 μg/mL, 58 μg/mL, 26 μg/mL, and 26 μg/mL, respectively.
Geomorphology of the Curueño River headwaters, Cantabrian mountains (NW Spain)
Creators: name: R. B. González-Gutiérrez
name: J. Santos-González
name: A. Gómez-Villar
name: J. M. Redondo-Vega
name: I. Prieto-Sarro
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Computational Biology

description: The article presents the 1:25,000-scale geomorphological map of the upper reaches of the Curueño River, on the southern slope of the Central Cantabrian Mountains, NW Spain. The study area spans approximately 125 km2 and corresponds to the 1:25,000-scale Spanish National Topographical Map Sheet 104-I of Lugueros. The area is moderately mountainous with elevation ranging from 1100 to 2100 m.a.s.l. The main landforms are river gorges, karst, and glacial landforms. The map legend contains 78 elements divided into 9 groups: litho-structural, polygenic, karst, fluvial, glacial, periglacial, nival, gravitational, weathering, and anthropic forms. The map was prepared using Esri ArcGIS with the Universal Transverse Mercator (UTM, Zone 30) projection. In addition, a database and style set were created for each landform with the goal of using this set of symbols in other areas and performing complementary mapping of geologic and geomorphologic risk, protection of natural geoheritage, land-use classification, and applied geomorphology.
A new flavonol glycoside from the florets of Carthamus tinctorius L.
Creators: name: Sun, Lin
name: Song, Yaling
name: Wang, Xuejing
name: Huang, Wenzhe
name: Wang, Zhenzhong
name: Xiao, Wei
name: Xie, Xue
name: Zhou, Jianming
name: Zhang, Hongda
name: Zhao, Yiwu
name: Ni, Fuyong
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Molecular Biology
subject: Cell Biology
subject: Microbiology
subject: Biochemistry

description: One new flavonol glycoside, 6-hydroxykaempferol-3-O-β-D-glucoside-7-O-β-D-glucuronide (1), together with eight known flavonoids and three known quinochalcones, was isolated from the florets of Carthamus tinctorius L. Their structures were determined by extensive spectroscopic analyses. Their cardioprotective effects against H2O2-induced apoptosis in H9c2 cells were also evaluated; compounds 1, 2, 4–5, 7–10 and 12 provided significant protective effects on H2O2-induced H9c2 cells at the concentration of 25 μg/mL.
Creating a Transparent and Interoperable Curation Workflow
Creators: name: Cooper, Talya
Publisher: name: Zenodo
Year: 2024
Subjects: Data curation
Workflow development

description: NYU IT and Data Services launched a new research repository, UltraViolet (made with InvenioRDM), in May 2022. Prior to opening the service, the curation team spent significant time planning and designing a transparent, interoperable workflow. Influenced by the collaborative curation model of the Data Curation Network, including their CURATE(D) steps, the team decided to use shared file and information management systems, with no crucial pieces of communication or tracking left in an individual’s email or personal documents. The workflow weaves together several tools, all of which were previously available and familiar to system users. Patrons begin by entering metadata about a deposit in a Qualtrics form, which feeds into Springshare’s LibAnswers portal. An available curator responds using a LibAnswers macro and supplies a Globus upload link; the researcher then adds their files. As the curator reviews the files and communicates with the researcher, they can use internal notes and templates in LibAnswers that incorporate DCN CURATE(D) checklists to ensure the curator stays attuned to crucial pieces of the curation workflow and maintains a log our whole team can access. All communication with the researcher (both emails and notes from conversations) also stays in LibAnswers, enabling other curators to pick up or refer back to the conversation. For large data, curators can also use an API to connect Globus directly to UltraViolet. This connection automatically loads data to the appropriate record in UltraViolet, transferring the files to our preservation repository while maintaining an ready access copy. The poster depicts this workflow and points to some future refinements and improvements we hope to make, such as connections with other InvenioRDM tools and automations.
A new quinolinone and its natural/artificial derivatives from a shark gill-derived fungus Penicillium polonicum AP2T1
Creators: name: Zhang, Yi
name: Mu, Jun
name: Essmann, Frank
name: Feng, Yan
name: Kramer, Markus
name: Bao, Hai-yan
name: Grond, Stephanie
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: Four quinolinones (1–4; 1 is a new compound) were isolated from the static fermentation culture of a shark gill-derived fungus Penicillium crustosum AP2T1. In addition, five new quinolinone derivatives (5–9) and also 1 were obtained in a trimethylsilyldiazomethane-induced methylation reaction of 4. Their structures were elucidated by spectroscopic analyses. In bioassays, compounds 7 and 5 with lactim structures moderately inhibited the proliferation of human cancer cell line HCT116 (wild-type) with IC50-24 h of 8.4 μg/mL and 30.7 μg/mL, respectively; the other compounds displayed weaker inhibition. The p53 gene may play some role in their action as suggested by their much weakened activity towards p53-knockout HCT116 cell line. Besides, 6 and 8 exhibited moderate or weak toxicity to brine shrimp larvae, and 3, 4, 8 and 9 showed weak inhibition against Staphylococcus aureus. It is the first report on elucidation of new compounds with origin of shark-derived fungi.
A new quinolinone and its natural/artificial derivatives from a shark gill-derived fungus Penicillium crustosum AP2T1
Creators: name: Zhang, Yi
name: Mu, Jun
name: Feng, Yan
name: Grond, Stephanie
name: Essmann, Frank
name: Kramer, Markus
name: Bao, Hai-yan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Pharmacology
subject: Microbiology
subject: FOS: Biological sciences
subject: Biochemistry

description: Four quinolinones (1–4; 1 is a new compound) were isolated from the static fermentation culture of a shark gill-derived fungus Penicillium crustosum AP2T1. In addition, five new quinolinone derivatives (5–9) and also 1 were obtained in a trimethylsilyldiazomethane-induced methylation reaction of 4. Their structures were elucidated by spectroscopic analyses. In bioassays, compounds 7 and 5 with lactim structures moderately inhibited the proliferation of human cancer cell line HCT116 (wild-type) with IC50-24 h of 8.4 μg/mL and 30.7 μg/mL, respectively; the other compounds displayed weaker inhibition. The p53 gene may play some role in their action as suggested by their much weakened activity towards p53-knockout HCT116 cell line. Besides, 6 and 8 exhibited moderate or weak toxicity to brine shrimp larvae, and 3, 4, 8 and 9 showed weak inhibition against Staphylococcus aureus. It is the first report on elucidation of new compounds with origin of shark-derived fungi.
Proximity_Study2_protocol_020517.docx
Creators: name: Hunter, Jennifer
name: Hollands, Gareth
name: Dominique-Laurent Couturier
name: Marteau, Theresa
Publisher: name: figshare
Year: 2017
Subjects: subject: 111712 Health Promotion
subject: FOS: Health sciences
subject: 111104 Public Nutrition Intervention
subject: 111799 Public Health and Health Services not elsewhere classified

description: The second in a series of experimental studies testing a dietary intervention that alters the distance at which an unhealthy snack food is placed to impact consumption.
European Commission's SWITCH-Asia Programme: Country case study -- Sustainable Consumption and Production in the Philippines
Creators: name: Sta. Romana, Leonardo L.
Publisher: name: Zenodo
Year: 2015
Subjects: Consumption, Production, Environment, Sustainability, Sustainable Development, Sustainable Development Goals, Developing countries, Philippines, South East Asia, Pollution, Climate change, Externalities

description: ABSTRACT This chapter examines the patterns of consumption and production in the Philippines and analyses their impact on the environment and climate, with a view to finding out whether they are environmentally sustainable or not.
 It presents the initial findings of the author's research on the topic of sustainable development in the Philippines. It looks first at the national policy and legal framework relating to sustainable consumption and production (SCP). Then it reviews indicators that attempt to assess the overall state of environment in the country, together with those that take stock of the country's ecological footprint and emissions of greenhouse gases. It also
 delves into indicators on air pollution and the generation of waste materials.
 Next, it discusses the state of micro-, small-, and medium-sized enterprises
 (MSMEs) in the country, and notes how policy and logistical support towards them is relevant to the issue of inclusive growth and poverty alleviation. It then looks at the case studies of two SWITCH-Asia projects in the country that are related to MSMEs and which have already been completed.
 Lastly, it looks into the on-going SWITCH-Asia National Policy Support
 Component that provides technical assistance and support to the national government on SCP-related policy and implementation issues.
description: An edited (shorter) version of this paper appears as a chapter in the book, SUSTAINABLE ASIA: Supporting the Transition to Sustainable Consumption and Production in Asian Developing Countries (World Scientific, Feb 2017). The e-book version can be accessed for free, with the compliments of the European Commission's SWITCH-Asia Programme, at: http://www.worldscientific.com/worldscibooks/10.1142/9862
Does occupational exposure to formaldehyde cause hematotoxicity and leukemia-specific chromosome changes in cultured myeloid progenitor cells?
Creators: name: Mundt, Kenneth A.
name: Gallagher, Alexa E.
name: Dell, Linda D.
name: Natelson, Ethan A.
name: Boffetta, Paolo
name: P. Robinan Gentry
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Cancer
subject: Science Policy
subject: Hematology

description: Several cross-sectional studies of a single population of workers exposed to formaldehyde at one of two factories using or producing formaldehyde–melamine resins in China have concluded that formaldehyde exposure induces damage to hematopoietic cells that originate in the bone marrow. Moreover, the investigators interpret observed differences between groups as evidence that formaldehyde induces myeloid leukemias, although the mechanisms for inducing these diseases are not obvious and recently published scientific findings do not support causation. Our objective was to evaluate hematological parameters and aneuploidy in relation to quantitative exposure measures of formaldehyde. We obtained the study data for the original study (Zhang et al. 2010) and performed linear regression analyses. Results showed that differences in white blood cell, granulocyte, platelet, and red blood cell counts are not exposure dependent. Among formaldehyde-exposed workers, no association was observed between individual average formaldehyde exposure estimates and frequency of aneuploidy, suggested by the original study authors to be indicators of myeloid leukemia risk.
Placental Expression Profile of Imprinted Genes Impacts Birth Weight
Creators: name: A Kappil, Maya
name: B Green, Benjamin
name: A Armstrong, David
name: J Sharp, Andrew
name: Lambertini, Luca
name: J Marsit, Carmen
name: Chen, Jia
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Developmental Biology
subject: Biological Sciences
subject: Earth and Environmental Sciences
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Medicine

description: The importance of imprinted genes in regulating feto-placental development has been long established. However, a comprehensive assessment of the role of placental imprinted gene expression on fetal growth has yet to be conducted. In this study, we examined the association between the placental expression of 108 established and putative imprinted genes and birth weight in 677 term pregnancies, oversampled for small for gestational age (SGA) and large for gestational age (LGA) infants. Using adjusted multinomial regression analyses, a two-fold increase in the expression of 9 imprinted genes were positively associated with LGA status (BLCAP (Odds ratio=3.78, [95% Confidence interval: 1.83, 7.82]), DLK1 (1.63, [1.27, 2.09]), H19 (2.79, [1.77, 4.42]), IGF2 (1.43, [1.31, 2.40]), MEG3 (1.42, [1.19, 1.71]), MEST (4.78, [2.64, 8.65]), NNAT (1.40, [1.05, 1.86]), NDN (2.52, [1.72, 3.68], PLAGL1 (1.85, [1.40, 2.44])). For SGA status, a two-fold increase of MEST expression was associated with decreased risk (0.31, [0.17, 0.58]) while a two-fold increase of NNAT expression was associated with increased risk (1.52, [1.1, 2.1]). Following a factor analysis, all genes significantly associated with SGA or LGA status loaded onto 2 of the 8 gene-sets underlying the variability in the dataset. Our comprehensive placental profiling of imprinted genes in a large birth cohort supports the importance of these genes for fetal growth. Given that abnormal birth weight is implicated in numerous diseases and developmental abnormalities, the expression pattern of placental imprinted genes has the potential to be developed as a novel biomarker for postnatal health outcomes.
title: 03_0274
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Single Bone Forearm for Post Traumatic Bone Defect: A Case Report
Creators: name: Abid .H
name: Elayoubi .A
name: El Idrissi .M
name: Shimi .M
name: El Ibrahimi .A
name: El Mrini, A.
Publisher: name: figshare
Year: 2018
Subjects: subject: 110322 Rheumatology and Arthritis
subject: FOS: Clinical medicine

description: 22 years old male patient was victim of severe trauma of the left upper Limb causing multiple fractures of the clavicle, humerus, radius with large bone defect of the ulna. Soft tissues damage was also significant with section of median and ulnar nerve, radial artery, flexor tendons of the hand and fingers. Treatment consisted initially to realize excision of devitalised and contaminated tissues from the wound, obtain skeletal stabilization with restoration of the upper limb length, and exceed the cap of infection. Secondarily, the one bone forearm procedure was performed to recover maximum of function. One year and half after injury, the patient had full elbow flexion-extension with very satisfactory fingers mobility
Placental expression profile of imprinted genes impacts birth weight
Creators: name: A Kappil, Maya
name: B Green, Benjamin
name: A Armstrong, David
name: J Sharp, Andrew
name: Lambertini, Luca
name: J Marsit, Carmen
name: Chen, Jia
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Developmental Biology
subject: Biological Sciences
subject: Earth and Environmental Sciences
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Medicine

description: The importance of imprinted genes in regulating feto-placental development has been long established. However, a comprehensive assessment of the role of placental imprinted gene expression on fetal growth has yet to be conducted. In this study, we examined the association between the placental expression of 108 established and putative imprinted genes and birth weight in 677 term pregnancies, oversampled for small for gestational age (SGA) and large for gestational age (LGA) infants. Using adjusted multinomial regression analyses, a 2-fold increase in the expression of 9 imprinted genes was positively associated with LGA status: BLCAP [odds ratio (OR) = 3.78, 95% confidence interval (CI): 1.83, 7.82], DLK1 [OR = 1.63, 95% CI: 1.27, 2.09], H19 [OR = 2.79, 95% CI: 1.77, 4.42], IGF2 [OR = 1.43, 95% CI:1.31, 2.40], MEG3 [OR = 1.42, 95% CI: 1.19, 1.71], MEST [OR = 4.78, 95% CI: 2.64, 8.65], NNAT [OR = 1.40, 95% CI: 1.05, 1.86], NDN [OR = 2.52, 95% CI: 1.72, 3.68], and PLAGL1 [OR = 1.85, 95% CI: 1.40, 2.44]. For SGA status, a 2-fold increase in MEST expression was associated with decreased risk [OR = 0.31, 95% CI: 0.17, 0.58], while a 2-fold increase in NNAT expression was associated with increased risk [OR = 1.52, 95% CI: 1.1, 2.1]. Following a factor analysis, all genes significantly associated with SGA or LGA status loaded onto 2 of the 8 gene-sets underlying the variability in the dataset. Our comprehensive placental profiling of imprinted genes in a large birth cohort supports the importance of these genes for fetal growth. Given that abnormal birth weight is implicated in numerous diseases and developmental abnormalities, the expression pattern of placental imprinted genes has the potential to be developed as a novel biomarker for postnatal health outcomes.
Biochemical Markers in Osteoarthritis
Creators: name: Verttí, Rubén Daniel Arellano Pérez
name: Astorga, Jesús Rafael Argüello
name: Morán-Martínez .J
name: García-Marín AY
name: Guzmán DD
name: ñiz, Lizette Sarai Aguilar Mu-
name: Gonzalez-Galarza FF
Publisher: name: figshare
Year: 2018
Subjects: subject: 110322 Rheumatology and Arthritis
subject: FOS: Clinical medicine
subject: 110314 Orthopaedics

description: Osteoarthritis (OA) is a chronic disease with a long silent period. The hallmarks of osteoarthritis (OA) include cartilage loss that leads to joint destruction and severe impairment of mobility. Involvement of subchondral bone and synovial tissue is well documentated. OA is the most prevalent cause of disability in the aging population of developing countries.The diagnosis is generally based on clinical symptoms and radiographic changes. However, X-ray has a poor sensitivity that does not allow an early detection of OA or the monitoring of joint damage progression. Another imaging technique is the magnetic resonance imaging (MRI). Although this medical test is more sensitive than plain radiography, it is more expensive and can´t be routinely applied to many patients. The limitations offered by such tools have cleared the need to identify more specific biological markers, which evaluate quantitative variations in joint remodeling, diagnostic, prognostic and efficacy of intervention. OA affects cartilage, subchondral bone, and synovium. Thus, molecules derived from these tissues could be considered as candidates for biological markers in OA, as these molecules have a role in metabolic processes in the joints. Recent data indicates that some markers could be valuable to diagnose, predict OA progression and assess therapeutic response; however, the interpretation of results should be careful because tissue specificity, clearance rates and circadian variations are still under investigation in most of biomarkers. Although biomarkers could be considered valuable tools, they still have some limitations in clinical practice and it is necessary to develop and validate specific and sensitive biomarkers.
Placental expression profile of imprinted genes impacts birth weight
Creators: name: A Kappil, Maya
name: B Green, Benjamin
name: A Armstrong, David
name: J Sharp, Andrew
name: Lambertini, Luca
name: J Marsit, Carmen
name: Chen, Jia
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Computational Biology

description: The importance of imprinted genes in regulating feto-placental development has been long established. However, a comprehensive assessment of the role of placental imprinted gene expression on fetal growth has yet to be conducted. In this study, we examined the association between the placental expression of 108 established and putative imprinted genes and birth weight in 677 term pregnancies, oversampled for small for gestational age (SGA) and large for gestational age (LGA) infants. Using adjusted multinomial regression analyses, a 2-fold increase in the expression of 9 imprinted genes was positively associated with LGA status: BLCAP [odds ratio (OR) = 3.78, 95% confidence interval (CI): 1.83, 7.82], DLK1 [OR = 1.63, 95% CI: 1.27, 2.09], H19 [OR = 2.79, 95% CI: 1.77, 4.42], IGF2 [OR = 1.43, 95% CI:1.31, 2.40], MEG3 [OR = 1.42, 95% CI: 1.19, 1.71], MEST [OR = 4.78, 95% CI: 2.64, 8.65], NNAT [OR = 1.40, 95% CI: 1.05, 1.86], NDN [OR = 2.52, 95% CI: 1.72, 3.68], and PLAGL1 [OR = 1.85, 95% CI: 1.40, 2.44]. For SGA status, a 2-fold increase in MEST expression was associated with decreased risk [OR = 0.31, 95% CI: 0.17, 0.58], while a 2-fold increase in NNAT expression was associated with increased risk [OR = 1.52, 95% CI: 1.1, 2.1]. Following a factor analysis, all genes significantly associated with SGA or LGA status loaded onto 2 of the 8 gene-sets underlying the variability in the dataset. Our comprehensive placental profiling of imprinted genes in a large birth cohort supports the importance of these genes for fetal growth. Given that abnormal birth weight is implicated in numerous diseases and developmental abnormalities, the expression pattern of placental imprinted genes has the potential to be developed as a novel biomarker for postnatal health outcomes.
Subungual Nodule of the Great Toe in Female Child
Creators: name: N. Amraoui
name: S. Gallouj
name: M. Meziane
name: H. Abid
name: A.El Mrini
name: K. Moumna
name: T. Harmouch
name: F. Mernissi
Publisher: name: figshare
Year: 2018
Subjects: subject: 110322 Rheumatology and Arthritis
subject: FOS: Clinical medicine

description: Subungual exostoses are bony projections which arise from the dorsal surface of the distal phalanx, most commonly of the hallux, often disturbing the nail plate and causing pain. We report case of subungual exostosis in a female child of 10 years who presented since one year a fixed firm nodule of the great toe. Clinically, radiologic and histological finding were compatible with subungual exostosis. The treatment is surgical. Early diagnosis avoids nail dystrophy
Staged Surgical Management of Multiple Fractures in Polytrauma Patient
Creators: name: MA, Hafez
name: Mohsen .A
name: Hamza .H
Publisher: name: figshare
Year: 2018
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110322 Rheumatology and Arthritis

description: Multiple trauma usually results from RTAs or falls, affecting several systems. Treatment should be properly designated according to the type of injury, patient's assessment and health-care-serving status. Damage-control orthopaedics aims at improving the patient's physiological status as to delay any orthopaedic surgery that may worsen the patient's condition, meanwhile achieving provisional stability of the fractures. In this work, a patient with multiple fractures at once was managed using this approach. Advanced trauma life support (ATLS) was firstly applied, followed by reduction and fixation. The patient administered long- term prophylactic antibiotics and possessed physiotherapy sessions from the first week. On 3 and 6 months postoperatively, the patient showed progress and regained his ability to work and live normally
title: 01_0203
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Efficient Protocol for the Synthesis of Novel Spiro[acenaphthylene-1,2′-pyrrolidin]-2-one Compounds
Creators: name: Lin, Yan
name: Fu, Zhijie
name: Shen, Tianhua
name: Che, Fengfeng
name: Song, Qingbao
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Earth and Environmental Sciences
Biotechnology
Cell Biology
Physics
Biochemistry
Biophysics

description: An efficient catalyst-free synthesis of 3′-benzoyl-4′,5′-diphenyl-2H-spiro[acenaphthylene-1,2′-pyrrolidin]-2-one derivatives via one-pot 1,3-dipolar cycloaddition of acenaphthenequinone, arylmethyl amines, and chalcones with high regioselectivity is described. The structure of the cycloadducts were characterized by infrared, high-resolution mass spectrometry (electrospray ionization), 1H NMR, and 13C NMR spectra, and the structure of 4a was confirmed using x-ray single-crystal structure analysis.
An Efficient Protocol for the Synthesis of Novel Spiro[Acenaphthylene-1,2′-pyrrolidin]-2-one Compounds
Creators: name: Lin, Yan
name: Fu, Zhijie
name: Shen, Tianhua
name: Che, Fengfeng
name: Song, Qingbao
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Earth and Environmental Sciences
Biotechnology
Cell Biology
Physics
Biochemistry
Biophysics

description: An efficient catalyst-free synthesis of 3′-benzoyl-4′,5′-diphenyl-2H-spiro[acenaphthylene-1,2′-pyrrolidin]-2-one derivatives via one-pot 1,3-dipolar cycloaddition of acenaphthenequinone, arylmethyl amines, and chalcones with high regioselectivity is described. The structure of the cycloadducts were characterized by IR, HRMS (ESI), 1H-NMR, 13C-NMR spectra and the structure of 4a was confirmed using X-ray single crystal structure analysis.
Single Bone Forearm for Post Traumatic Bone Defect: A Case Report
Creators: name: SciDoc Publishers
name: H, Abid
name: Elayoubi A
name: El Idrissi M,
name: Shimi M
name: A, El Ibrahimi
name: A, El Mrini
Publisher: name: figshare
Year: 2017
Subjects: subject: 110322 Rheumatology and Arthritis
subject: FOS: Clinical medicine

description: 22 years old male patient was victim of severe trauma of the left upper Limb causing multiple fractures of the clavicle, humerus, radius with large bone defect of the ulna. Soft tissues damage was also significant with section of median and ulnar nerve, radial artery, flexor tendons of the hand and fingers. Treatment consisted initially to realize excision of devitalised and contaminated tissues from the wound, obtain skeletal stabilization with restoration of the upper limb length, and exceed the cap of infection. Secondarily, the one bone forearm procedure was performed to recover maximum of function. One year and half after injury, the patient had full elbow flexion-extension with very satisfactory fingers mobility
Biochemical Markers in Osteoarthritis
Creators: name: SciDoc Publishers
name: Verttí, Rubén Daniel Arellano Pérez
name: Astorga, Jesús Rafael Argüello
name: Morán-Martínez J
name: García-Marín AY
name: Guzmán DD
name: ñiz, Lizette Sarai Aguilar Mu-
name: Gonzalez-Galarza FF
Publisher: name: figshare
Year: 2017
Subjects: subject: 110322 Rheumatology and Arthritis
subject: FOS: Clinical medicine
subject: 110314 Orthopaedics

description: Osteoarthritis (OA) is a chronic disease with a long silent period. The hallmarks of osteoarthritis (OA) include cartilage loss that leads to joint destruction and severe impairment of mobility. Involvement of subchondral bone and synovial tissue is well documentated. OA is the most prevalent cause of disability in the aging population of developing countries.The diagnosis is generally based on clinical symptoms and radiographic changes. However, X-ray has a poor sensitivity that does not allow an early detection of OA or the monitoring of joint damage progression. Another imaging technique is the magnetic resonance imaging (MRI). Although this medical test is more sensitive than plain radiography, it is more expensive and can´t be routinely applied to many patients. The limitations offered by such tools have cleared the need to identify more specific biological markers, which evaluate quantitative variations in joint remodeling, diagnostic, prognostic and efficacy of intervention. OA affects cartilage, subchondral bone, and synovium. Thus, molecules derived from these tissues could be considered as candidates for biological markers in OA, as these molecules have a role in metabolic processes in the joints. Recent data indicates that some markers could be valuable to diagnose, predict OA progression and assess therapeutic response; however, the interpretation of results should be careful because tissue specificity, clearance rates and circadian variations are still under investigation in most of biomarkers. Although biomarkers could be considered valuable tools, they still have some limitations in clinical practice and it is necessary to develop and validate specific and sensitive biomarkers.
Serum Cartilage Oligomeric Matrix Protein: Tool for early diagnosis and grading of severity of primary knee osteoarthritis.
Creators: name: Singh, Sudhir
name: Utkarsh Shahi
name: Dharmendra Kumar
name: Shahi, Neha Tiwari
Publisher: name: figshare
Year: 2018
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110322 Rheumatology and Arthritis

description: Context: With increasing elderly population there is increasing prevalence of primary degenerative knee osteoarthritis (KOA), but specific and sensitive tests to diagnose and ascertain the severity of such ailments are lacking. Bone and cartilage biomarkers, like serum Cartilage Oligomeric Matrix Protein (sCOMP) level show changes much before than clinical or radiological changes. So far it has not been used in clinical practice as the diagnostic range of serum COMP levels have not been defined. Aims: The aim of present study was to assess the efficacy of sCOMP levels in diagnosis of different grades of severity of primary knee osteoarthritis. Settings and design: A hospital based prospective case control study recruiting 100 cases and 50 controls. Methods and material: All subjects were examined clinically and further evaluated by plain radiography and serum COMP values were estimated by enzyme linked immune-sorbent assay (ELISA). Multiple statistical tools were used to analyse the results. Results: The difference between sCOMP values among cases and controls was statistically significant (t=21.774; p<0.001). The mean sCOMP also shows a gradual increase with increase in severity of knee osteoarthritis. [F=38.940; p<0.001 (ANOVA)]. Conclusions: The serum COMP levels can be used to diagnose normal and diseased individual and also assess different grades of severity of knee osteoarthritis. We suggest cut off levels of sCOMP of 652.5 nano gram/deci litre (ng/dl) between normal and diseased individual, of 801.5 ng/dl between mild and moderate grade of osteoarthritis, and of 1100.5 ng/dl between moderate and severe grade of knee Osteoarthritis (KOA)
Nonparametric Inference for Time-Varying Coefficient Quantile Regression
Creators: name: Wu, Weichi
name: Zhou, Zhou
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Mathematical Sciences not elsewhere classified

description: The article considers nonparametric inference for quantile regression models with time-varying coefficients. The errors and covariates of the regression are assumed to belong to a general class of locally stationary processes and are allowed to be cross-dependent. Simultaneous confidence tubes (SCTs) and integrated squared difference tests (ISDTs) are proposed for simultaneous nonparametric inference of the latter models with asymptotically correct coverage probabilities and Type I error rates. Our methodologies are shown to possess certain asymptotically optimal properties. Furthermore, we propose an information criterion that performs consistent model selection for nonparametric quantile regression models of nonstationary time series. For implementation, a wild bootstrap procedure is proposed, which is shown to be robust to the dependent and nonstationary data structure. Our method is applied to studying the asymmetric and time-varying dynamic structures of the U.S. unemployment rate since the 1940s. Supplementary materials for this article are available online.
Nonparametric Inference for Time-varying Coefficient Quantile Regression
Creators: name: Zhou, Zhou
name: Wu, Weichi
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Genetics
subject: Medicine

description: The paper considers nonparametric inference for quantile regression models with time-varying coefficients. The errors and covariates of the regression are assumed to belong to a general class of locally stationary processes and are allowed to be cross-dependent. Simultaneous confidence tubes (SCT) and integrated squared difference tests (ISDT) are proposed for simultaneous nonparametric inference of the latter models with asymptotically correct coverage probabilities and type I error rates. Our methodologies are shown to possess certain asymptotically optimal properties. Furthermore, we propose an information criterion which performs consistent model selection for nonparametric quantile regression models of non-stationary time series. For implementation, a wild bootstrap procedure is proposed which is shown to be robust to the dependent and non-stationary data structure. Our method is applied to studying the asymmetric and time-varying dynamic structures of the US unemployment rate since the 1940s.
Staged Surgical Management of Multiple Fractures in Polytrauma Patient
Creators: name: SciDoc Publishers
name: MA, Hafez
name: A, Mohsen
name: H, Hamza
Publisher: name: figshare
Year: 2017
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110322 Rheumatology and Arthritis

description: Multiple trauma usually results from RTAs or falls, affecting several systems. Treatment should be properly designated according to the type of injury, patient's assessment and health-care-serving status. Damage-control orthopaedics aims at improving the patient's physiological status as to delay any orthopaedic surgery that may worsen the patient's condition, meanwhile achieving provisional stability of the fractures. In this work, a patient with multiple fractures at once was managed using this approach. Advanced trauma life support (ATLS) was firstly applied, followed by reduction and fixation. The patient administered long- term prophylactic antibiotics and possessed physiotherapy sessions from the first week. On 3 and 6 months postoperatively, the patient showed progress and regained his ability to work and live normally
Simultaneous determination of seven bioactive components in Guizhi Fuling capsule by microwave-assisted extraction combined with ultra performance liquid chromatography tandem mass spectrometry
Creators: name: Sui, Yang
name: Zhao, Long-Shan
name: Wang, Zhen-zhong
name: Xiao, Wei
name: Xiong, Zhi-Li
name: Zhao, Yu-Tong
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Biological Sciences
subject: Ecology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Pharmacology
subject: Genetics
subject: Engineering
subject: Biochemistry

description: A simple, rapid and reliable microwave-assisted extraction (MAE) combined with ultra performance liquid chromatography tandem mass spectrometry method was developed for simultaneous determination of the seven bioactive constituents in Guizhi Fuling capsule (GFC), namely gallic acid, amygdalin, albiflorin, paeoniflorin, paeonol, cinnamic acid and pachymic acid, respectively. The operation of MAE optimised through orthogonal array design experiment was performed at 80°C for 10 min with methanol–water (70:30, v/v) as the extracting solvent. The method was validated including intra- and inter-day precision, repeatability and stability, with relative standard deviation less than 3.9%, 3.3%, 4.4% and 3.1%, respectively. All analytes showed the good linearity (r >0.999), and their average recoveries varied between 98.2% and 101.2%. The results indicated that this method was simple, effective and suitable for the quality control of GFC.
Non-alkaloids extract from Stemona sessilifolia enhances the activity of chemotherapeutic agents through P-glycoprotein-mediated multidrug-resistant cancer cells
Creators: name: Han, Lu
name: Ma, Yang-Mei
name: An, Li
name: Zhang, Qiao
name: Wang, Chang-Li
name: Zhao, Qing-Chun
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: One of the major impediments to the successful treatment of cancer is the development of resistant cancer cells, which could cause multidrug resistance (MDR), and overexpression of ABCB1/P-glycoprotein (P-gp) is one of the most common causes of MDR in cancer cells. Recently, natural products or plant-derived chemicals have been investigated more and more widely as potential multidrug-resistant (MDR) reversing agents. The current study demonstrated for the first time that non-alkaloids extract from Stemona sessilifolia significantly reversed the resistance of chemotherapeutic agents, adriamycin, paclitaxel and vincristine to MCF-7/ADR cells compared with MCF-7/S cells in a dose-dependent manner. The results obtained from these studies indicated that the non-alkaloids extract from S. sessilifolia plays an important role in reversing MDR of cancer as a P-gp modulator in vitro and may be effective in the treatment of multidrug-resistant cancers.
Study of Insulin Secretory Response after Oral Glucose Load in Obese Subjects
Creators: name: Anuradha .K
name: Mathur, R.
Publisher: name: figshare
Year: 2018
Subjects: subject: 30201 Bioinorganic Chemistry
subject: FOS: Chemical sciences

description: Background: Insulin resistance leads to impaired glucose tolerance, dyslipidemia, and other adverse cardiovascular effects. Increased insulin resistance will lead to hyperinsulinemia which is a characteristic feature of obesity, hypertension and type 2 Diabetes mellitus. Aims: The present study was designed to investigate insulin secretory response and glucose abnormalities after oral glucose load in obese subjects. Material and Method: The present study was carried out on 25 healthy controls and 25 obese subjects of either sex and of varying age groups attending the Out Patient Department of Medicine, Dr. S.N. Medical College and Associated group of hospitals, Jodhpur. Results: The results obtained in this study showed that the results of standard OGTT and corresponding insulin response during fasting, after 1 hour & 2 hour were significantly higher in patients compared with control subjects. Conclusion: The present study indicates an increased insulin secretory response in obese subjects, which is due to higher insulin resistance.
Tinnitus - Characteristics and Therapy
Creators: name: Dziuganowska, Zofia A.
Publisher: name: figshare
Year: 2018
Subjects: subject: 30201 Bioinorganic Chemistry
subject: FOS: Chemical sciences

description: Many papers have been published so far that the need for an updated review prompted the author to write this article and to describe historical perspective, characteristics, epidemiology, causes, pathophysiology, and treatments of tinnitus. Despite of the common opinion, this one of the most annoying of ear disorders, has been known from the Antiquity. Nowadays, it touches about 11% of population of Western Europe. Tinnitus, as the complex symptom, is associated with other annoying ear disorders. While indication of its reason is very often impossible, the factors contributing to the development of disorder were determined. Several theories explaining the mechanism of tinnitus have showed that extensive levels of nervous system may be involved in its generation. Although no convincing treatment is available, some alleviating therapies are recommended. They can be divided into two categories: relieving of its severity and reduction of its intensity
Subungual Nodule of the Great Toe in Female Child
Creators: name: SciDoc Publishers
name: N. Amraoui
name: S. Gallouj
name: M. Meziane
name: H.Abid
name: A.El Mrini
name: K.Moumna
name: T.Harmouch
name: F.Mernissi
Publisher: name: figshare
Year: 2017
Subjects: subject: 110322 Rheumatology and Arthritis
subject: FOS: Clinical medicine

description: Subungual exostoses are bony projections which arise from the dorsal surface of the distal phalanx, most commonly of the hallux, often disturbing the nail plate and causing pain. We report case of subungual exostosis in a female child of 10 years who presented since one year a fixed firm nodule of the great toe. Clinically, radiologic and histological finding were compatible with subungual exostosis. The treatment is surgical. Early diagnosis avoids nail dystrophy