cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Neoseius Oudemans 1903
Creators: name: Halliday, R. B.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Mesostigmata
Uropodidae
Neoseius

description: Neoseius Oudemans, 1903
Neoseius Oudemans, 1903: 100.
Type species Uroseius novus Oudemans, 1902: 47, by original designation.
description: Published as part of Halliday, R. B., 2015, Catalogue of genera and their type species in the mite Suborder Uropodina (Acari: Mesostigmata), pp. 101-147 in Zootaxa 3972 (2) on page 122, DOI: 10.11646/zootaxa.3972.2.1, http://zenodo.org/record/232777
title: I primi cinquant'anni del calcolo all'INFN di Napoli. La storia e le immagini, dal 1963 al 2013
Creators: name: Mastroserio, Paolo
Publisher: name: Satura Editrice
Year: 2014

description: L'Informatica è sicuramente uno dei principali elementi caratterizzanti della seconda metà del ventesimo secolo; ha rivoluzionato il modo di "far di conto" e ha rivoluzionato sia le modalità sia i contenuti della comunicazione.
Il mondo accademico e della ricerca hanno avuto un ruolo determinante nello sviluppo e nella crescita di questo settore, e la Sezione di Napoli dell'INFN è stata ben
presente in ogni fase di questo processo. In occasione della celebrazione del primo cinquantenario ci si è posti l'obiettivo di lasciare una traccia degli sforzi fatti, obiettivo che si è concretizzato con la stesura di questo libro che ne ripercorre le varie tappe succedute negli anni. Il lettore vedrà scorrere, anche grazie alle numerose immagini presenti, questi cinquant'anni come un filmato che inizia nei primi anni '60 fino ad arrivare al 2013.
Nel campo delle telecomunicazioni, si parte dai primi collegamenti tra Napoli e Milano con una velocità di 110 bps per arrivare agli oltre 10 Gbps dei giorni nostri. Nell'ambito del calcolo, vengono citati i primi calcolatori che venivano usati prima del 1984, anno in cui viene fissata la data di nascita del "Servizio Calcolo" in occasione dell'acquisto del VAX 11/750-B. Il racconto prosegue descrivendo le evoluzioni nell'ambito del calcolo, con particolare accento alla realizzazione della Grid e a tutti i protagonisti sia di staff sia precari che hanno contribuito al successo del "Servizio Calcolo e Reti" in questi primi cinquant'anni.
Waning waves of mood: The declining trend of hospitalized patients with affective disorders in Germany
Creators: name: Walter, Nike
name: Rupp, Markus
name: Lambert-Delgado, Adolfo
name: Mena, Alberto Erconvaldo Cobián
name: Hinterberger, Thilo
name: Loew, Thomas
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: Affective disorders; Epidemiology; Incidence; Nationwide analysis
subject: 610 Medizin

description: Introduction: Affective disorders profoundly affect individuals’ emotional well-being and quality of life. This
study investigates the epidemiology of affective disorders in Germany from 2011 to 2021, focusing on incidence
rates, age- and sex-standardized rates, and developmental trends.
Methods: Using nationwide data of ICD-10 diagnosis codes from 2011 to 2021, this cross-sectional study analyzed
inpatient cases of affective disorders in individuals aged 20 years or older. Age- and sex-standardized incidence
rates were calculated based on the population size of each birth cohort in the 16 German federal states. Incidence
rate ratios (IRRs) for 2011 to 2021 and 2019 to 2021 were compared with a two-sample z-test.
Results: Between 2011 and 2021, F30 (manic episode) showed a decline of 42.8 % to an incidence of 4.9 per
100,000 inhabitants, even though not statistically significant (p = 0.322). F31 (bipolar affective disorder)
remained relatively stable with a reduction of 15.3 % to an incidence of 13.6 per 100,000 inhabitants in 2021 (p
= 0.653). F32 (depressive episode) decreased statistically significant by 25.7 % to an incidence of 64.1 per
100,000 inhabitants (p = 0.072). F33 (recurrent depressive disorder) slightly increased by 18.3 % to an incidence
of 94.6 per 100,000 inhabitants (p = 0.267). No statistically significant differences were found when comparing
the COVID-19 pandemic year 2021 to 2019 incidences (p ≥ 0.529).
Conclusion: The study provides valuable insights into the changing landscape of affective disorders in Germany
over the past decade. The observed decline in incidence rates underscores the importance of continued efforts to
promote mental health awareness and access to care.
title: Raccolta notizie per la storia, arte, architettura di Napoli e contorni. Parte 3: Famiglie
Creators: name: Pinto, Aldo
Publisher: name: University of Napoli Federico II
Year: 2023

description: Raccolta di notizie edite e inedite (di archivio) su artisti, artigiani e famiglie attivi a Napoli per la maggior parte a partire dal XIV secolo.
Liptena durbania subsp. eukrinoides Talbot 1937
Creators: name: Libert, Michel
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Lycaenidae
Liptena
Liptena durbania
Liptena durbania eukrinoides talbot, 1937

description: Liptena durbania eukrinoides Talbot, 1937. stat rev.
(Figs 14–19)
Liptena eukrinoides Talbot, 1937. – New African Lycaenidae and Nymphalidae, and two new Diestogyna. Transactions of the Royal Entomological Society of London, 86: 64 (male and female, SW Uganda; illustrated pl. 1, Fig. 18).
Liptena eukrinoides Talbot, 1937 sensu Congdon & Collins, 1998: 60, d’Abrera, 2009: 649, Williams, 2022;
= Liptena eukrines f. female obsoleta Dufrane, 1953 sensu Williams, 2022.
Liptena minziro Collins & Larsen, 2008 sensu Collins & Larsen, 2008: 56.
Holotype: male, Tero forest, south-east Buddu, 3500ft., 26–30.ix.1911 (S.A. Neave); NHM.
Description:
On the upper side, the specimens of the eastern subspecies are generally a little smaller, a little more yellow, with a narrower black apical patch and a narrower costal margin on the forewings. These differences are observed in the specimens illustrated, but exceptions are not uncommon for each of the characters.
Genitalia:
Male genitalia differ from those of the nominate subspecies by the less indented uncus (Fig. 8) and the shorter, more robust and only slightly curved subunci (Fig. 6). On the valves, the dorsal point is stronger, the end of the distal plate is different and the ventral point is replaced by a wide plate, the difference being however visible only in ventral view (Fig. 7). The penis is similar, also twisted, but a little thinner; the fultura is similar.
In female genitalia, the ventral wall of the sinus vaginalis is wider, which results in a (slightly) narrower opening.
description: Published as part of Libert, Michel, 2023, Taxonomic notes on Liptena durbania Bethune-Baker, 1915 (Papilionoidea: Lycaenidae: Poritiinae), pp. 29-34 in Metamorphosis 34 (1) on page 32, DOI: 10.4314/met.v34i1.3, http://zenodo.org/record/14119290
Emerging presence of Actinomyces in perianal and pilonidal infection.
Creators: name: Tan, Chih Y
name: Javed, Muhammad A
name: Artioukh, Dmitri Y
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: subject: 3207 Medical Microbiology
subject: 32 Biomedical and Clinical Sciences
subject: 3202 Clinical Sciences
subject: Minority Health
subject: Emerging Infectious Diseases
subject: Infectious Diseases
subject: FOS: Health sciences
subject: 5.1 Pharmaceuticals
subject: Infection

description: Actinomyces is a rare aetiology of infections affecting the perianal region and natal cleft. Recognition of this microorganism is essential to deliver targeted antimicrobial therapy following surgical intervention. We present a series of 15 pilonidal and perianal infections associated with this microorganism. Actinomyces turicensis was the only strain of Actinomyces isolated. A total of 14 out of 15 cases had concomitant microorganisms isolated from microbiology specimens. Mixed anaerobes (n = 14) were the most common concomitant pathogens followed by Streptococcus milleri (n = 3), Staphylococcus aureus (n = 1), Citrobacter (n = 1) and Coliform bacteria (n = 1). All patients, except one who was pregnant at time of diagnosis, underwent surgical drainage with or without further oral antibiotic therapy. Coloproctologists need to consider Actinomyces as a clinically significant pathogen in the context of perianal and pilonidal infections.
title: Raccolta notizie per la storia, arte, architettura di Napoli e contorni. Parte 2.2: Luoghi (fuori del centro antico)
Creators: name: Pinto, Aldo
Publisher: name: University of Napoli Federico II
Year: 2023

description: Raccolta di notizie edite e inedite (di archivio) su artisti, artigiani e famiglie attivi a Napoli per la maggior parte a partire dal XIV secolo
Nobuohiramatsuia Hirschmann 1990
Creators: name: Halliday, R. B.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Mesostigmata
Uropodidae
Nobuohiramatsuia

description: Nobuohiramatsuia Hirschmann, 1990
Nobuohiramatsuia Hirschmann, 1990: 137.
Type species Deriaophorus crassus Hiramatsu, 1979a: 85, by original designation.
description: Published as part of Halliday, R. B., 2015, Catalogue of genera and their type species in the mite Suborder Uropodina (Acari: Mesostigmata), pp. 101-147 in Zootaxa 3972 (2) on page 122, DOI: 10.11646/zootaxa.3972.2.1, http://zenodo.org/record/232777
title: Raccolta notizie per la storia, arte, architettura di Napoli e contorni. Parte 2.1: Luoghi (centro antico)
Creators: name: Pinto, Aldo
Publisher: name: University of Napoli Federico II
Year: 2023

description: Raccolta di notizie edite e inedite (di archivio) su artisti, artigiani e famiglie attivi a Napoli per la maggior parte a partire dal XIV secolo.
Liptena durbania subsp. bergeri Stempffer, Bennett
Creators: name: Libert, Michel
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Lycaenidae
Liptena
Liptena durbania
Liptena durbania bergeri stempffer, bennett

description: Liptena durbania bergeri Stempffer, Bennett & May, 1974, stat rev. (Figs 20, 21)
Liptena bergeri Stempffer, Bennett & May, 1974. – A Revision of some groups of Liptena Westwood (Lepidoptera: Lycaenidae). Bulletin of the British Museum (Natural History) (Entomology), 30 (2): 177 (male, Shaba; not illustrated).
Liptena bergeri Stempffer, Bennett & May, 1974 sensu Berger, 1981: 191.
Holotype: male, Kafakumba (Katanga), iv.1929 (F.G. Overlaet); genitalia Stempffer 3592; MRAC.
Genitalia:
Stempffer et al. illustrate those of the male holotype (1974, Fig. 49). The figure shows a weakly indented uncus; the subunci seem closer to those of subspecies eukrinoides, but the angle of observation is not the same as for Fig. 6. On the valves, the most conspicuous character is the wide ventral plate, perhaps even wider than in subspecies eukrinoides.
description: Published as part of Libert, Michel, 2023, Taxonomic notes on Liptena durbania Bethune-Baker, 1915 (Papilionoidea: Lycaenidae: Poritiinae), pp. 29-34 in Metamorphosis 34 (1) on pages 32-33, DOI: 10.4314/met.v34i1.3, http://zenodo.org/record/14119290
Exploring Size and Shape with Multivariate Ratio Analysis (MRA)
Creators: name: Baur, Hannes
Publisher: name: Zenodo
Year: 2020
Subjects: statistics
morphometry
biometry
body measurements
linear distances
allometry
body ratios
parasitic wasps
Hymenoptera
insects
taxonomy
systematics
Pteromalidae
Dibrachys
cryptic species
species description
Multivariate Ratio Analysis
MRA
Principal Component Analysis
PCA
Linear Discriminant Analysis
LDA
shape PCA
LDA ratio extractor
distance measurements
PCA ratio spectrum

description: These guidelines follow from a paper on the analysis of ratios in multivariate morphometry by Baur and Leuenberger (2011). The paper is intended as a companion for those who prefer a more practical approach, for instance taxonomists, who would like to apply the MRA methods. Examples are demonstrated using a dataset of parasitic wasps of the genus Dibrachys (Hymenoptera: Pteromalidae).

In addition, R-scripts are provided, so that the Figs. 2-9 can be reproduced. However, for this it is necessary to also download the Dibrachys dataset (from Peters and Baur 2020), as well as the source files with the MRA functions (from Baur and Leuenberger 2020). For achieving best results, all files should be put in a single folder and R-Studio (or any other IDE) opened by clicking on one of the R-scripts.

All files are available individually and with an own link. For convenience, I have compiled all files also in a ZIP file.

Papers quoted above you may find in the section References of this Zenodo package.

Citation of this packageBaur, Hannes (2020, November 9) Exploring Size and Shape with Multivariate Ratio Analysis (MRA). Zenodo. https://doi.org/10.5281/zenodo.4256704.
Notaspis Koch 1835
Creators: name: Halliday, R. B.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Crambidae
Notaspis

description: Notaspis Koch, 1835
Notaspis Koch, 1835: 5.
Type species Notaspis obscurus Koch, 1835: 5, by monotypy.
Notes. The genus name Notaspis Koch, 1835 is a junior homonym of Notaspis Hermann, 1804, and was replaced by Pseuduropoda Oudemans, 1936 (see below).
description: Published as part of Halliday, R. B., 2015, Catalogue of genera and their type species in the mite Suborder Uropodina (Acari: Mesostigmata), pp. 101-147 in Zootaxa 3972 (2) on page 122, DOI: 10.11646/zootaxa.3972.2.1, http://zenodo.org/record/232777
The translocator protein 18kDa ligand etifoxine in the treatment of depressive disorders—a double-blind, randomized, placebo-controlled proof-of-concept study
Creators: name: Brunner, Lisa-Marie
name: Riebel, Marco
name: Wein, Simon
name: Koller, Michael
name: Zeman, Florian
name: Huppertz, Gunnar
name: Emmer, Tanja
name: Eberhardt, Yvonne
name: Schwarzbach, Jens
name: Rupprecht, Rainer
name: Nothdurfter, Caroline
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: Randomized controlled trial, TSPO, Etifoxine, Depression, Neurosteroids, Functional MRI, Microbiome
subject: 610 Medizin

description: Background

Recent developments suggest that neurosteroids may achieve rapid antidepressant effects. As such, neurosteroidogenesis mediated by the translocator protein 18 kDa (TSPO) might constitute a promising option for the treatment of depression. Therefore, the current clinical trial aims to get the first evidence of whether TPSO ligands promote rapid antidepressant effects. Furthermore, we study which mechanisms of action, e.g., modulation of distinct neuronal networks, neurosteroidogenesis, endocrinological mechanisms, TSPO expression or microbiome composition, contribute to their putative antidepressant effects.
Methods

This is a randomized, placebo-controlled, double-blind single-center trial of 2-week treatment with the TSPO ligand etifoxine versus placebo in depressive patients. Main eligibility criteria: male or female individuals aged 18 to 65 years with unipolar/bipolar depressive disorder with no other psychiatric main diagnosis or acute neurological/somatic disorder or drug/alcohol dependence during their lifetime.

The primary endpoint is the time point at which 50% of the maximal effect has occurred (ET50) estimated by the scores of the Hamilton Depression Scale (HAMD-21). A total of 20 patients per group are needed to detect changes of therapeutic efficacy about 5% and changes of ET50 about 10% with a power of 70%. Assuming a drop-out rate of 10–20%, 50 patients will be randomized in total. The study will be conducted at the Department of Psychiatry and Psychotherapy of the University of Regensburg.
Discussion

This study will provide a first proof-of-concept on the potential of the TSPO ligand etifoxine in the treatment of depressive disorders.
Trial registration

Clinical Trials Register (EudraCT number: 2021-006773-38, registration date: 14 September 2022) and German Register of Clinical Studies (DRKS number: DRKS00031099, registration date: 23 January 2023).
Evaluation of a Mothering Class for Refugee/Immigrant/Migrant Women on Patient Communication Self-Efficacy and Knowledge Acquisition
Creators: name: , Armenda Bialas
Publisher: name: Georgia State University
Year: 2024

description:
INTRODUCTION: Refugee/ immigrant/ and migrant (RIM) women are at particularly high risk of pregnancy-related health disparities in the United States. One strategy for addressing these health disparities and improving pregnancy- and childbirth-related outcomes is to provide RIM women with education about sexual and reproductive health (SRH) and maternal and child health (MCH) topics so that they are better able to effectively communicate with their health care provider. To this end, Embrace Refugee Birth Support provides a culturally tailored educational program, Healthy Moms, that provides expectant refugee women with information about SRH while emphasizing their health care right to make informed health decisions.


METHODS: An outcome evaluation of the Healthy Moms educational class series was conducted to evaluate the impact of the program. Using a pre-post evaluation design, participants (n=18) were evaluated on patient communication self-efficacy and sexual and maternal health knowledge acquisition. Data was collected separately between participants that were native to Afghanistan or African countries. Data was analyzed using descriptive statistics and paired sample t-tests (n=8).


RESULTS: Baseline SRH and MCH knowledge acquisition was measured among 18 participants. A one-way ANOVA revealed that there was a statistically significant difference in knowledge base between Afghanistan and African participants [F(1, 15) = [11.833], p=0.004)]. A paired samples t-test showed that the participants level of knowledge increased from baseline (Mean=9.75, SD=1.98) to follow-up (Mean=11.38, SD=2.67; t(7)=-1.72, p=0.129), though results were not statistically significant. A paired samples t-test showed that the participants level of communication self-efficacy with providers increased from baseline (Mean=36.57, SD=8.73) to follow-up (Mean=46.00, SD=2.77; t(6)=-2.92, p=0.027). Participants reported a high level of program satisfaction (Mean=11.38, SD=0.74).


DISCUSSION: Across participants, the results indicated a significant increase in patient communication self-efficacy over the course of the program. This evaluation did not find significant increases in knowledge acquisition. Most notably, however, at program entry, the results revealed topic areas in which participants were relatively knowledgeable or demonstrated deficits. This finding may have important implications for the Healthy Moms curriculum development.
Nothogynus Walter & Krantz 1999
Creators: name: Halliday, R. B.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Mesostigmata
Nothogynidae
Nothogynus

description: Nothogynus Walter & Krantz, 1999
Nothogynus Walter & Krantz, 1999: 69.
Type species Nothogynus klompeni Walter & Krantz, 1999: 69, by original designation.
description: Published as part of Halliday, R. B., 2015, Catalogue of genera and their type species in the mite Suborder Uropodina (Acari: Mesostigmata), pp. 101-147 in Zootaxa 3972 (2) on page 122, DOI: 10.11646/zootaxa.3972.2.1, http://zenodo.org/record/232777
Scoping Review of COVID-19 Infection and the Post Diagnosis of Anxiety
Creators: name: Roberts-Harley, Zenobia
Publisher: name: Georgia State University
Year: 2024

description:
INTRODUCTION: During the COVID-19 pandemic, numerous news and media outlets reported an increase in mental health dilemmas. Studies varied from anxiety caused due to fear of catching the virus to if contracted, how did the virus psychologically affect the person. These reports examined different areas of the population, especially healthcare workers, first responders, teachers, and persons with comorbidities. The purpose of this scoping review is to describe the research conducted on the relationship between testing positive for COVID-19 and subsequent diagnosis of anxiety.



METHODS: The study design utilized for this research was a scoping review. The literature search was conducted in PubMed. Eligible studies included adults ages 18 and over, who tested positive for COVID-19 by a medical professional, who were diagnosed with anxiety less than a year after testing positive for COVID-19, and were part of the general population (not classified to any subcategory, such as healthcare workers). This scoping review displayed or listed the characteristics, similarities, and/or differences in the studies containing the eligibility criteria.



RESULTS: A total of 455 articles were identified in PubMed. After screening of titles and abstract followed by full-text screening, 12 full-text published articles were used in the scoping review. Seven of the studies utilized prospective cohorts as study designs. Half of the studies utilized some type of regression analyses. In many of the studies, males tend to be the higher percentage of gender type. Most of the of the studies occurred in China, while only two were conducted in the United States. 11 of 12 of the studies reported the incidence of anxiety among study participants.



CONCLUSION: In the general population, more investigation and studies on COVID-19 by psychologists, epidemiologists, and statisticians, will need to be evaluated on anxiety. After the patient develops COVID-19, evaluations for anxiety are essential, in order to thrive against the overburdened healthcare agencies and establish a healthy population of productive citizens in the workforce and contributing some other positive skill in society. Future research includes parallel screening measurements and time durations from a participant testing positive for COVID-19 until being surveyed for anxiety.
High throughput application of the NanoBiT Biochemical Assay for the discovery of selective inhibitors of the interaction of PI3K-p110α with KRAS.
Creators: name: Ismail, Mohamed
name: Davies, Gareth
name: Sproat, Graham
name: Monteverde, Tiziana
name: Tart, Jonathan
name: Acebrón-García-de-Eulate, Marta
name: Gohlke, Andrea
name: Hancock, David
name: Adhikari, Santosh
name: Stefanovic-Barrett, Sandra
name: Smith, David M
name: Flemington, Vikki
name: Gleave-Hanford, Emma S
name: Holdgate, Geoffrey A
name: Kettle, Jason G
name: Downward, Julian
Publisher: name: The Francis Crick Institute
Year: 2024
Subjects: classificationCode: Chemical Biology & High Throughput
subject: Chemical Biology & High Throughput

description: The NanoBiT Biochemical Assay (NBBA) was designed as a biochemical format of the NanoBiT cellular assay, aiming to screen weak protein-protein interactions (PPIs) in mammalian cell lysates. Here we present a High Throughput Screening (HTS) application of the NBBA to screen small molecule and fragment libraries to identify compounds that block the interaction of KRAS-G12D with phosphatidylinositol 3-kinase (PI3K) p110α. This interaction promotes PI3K activity, resulting in the promotion of cell growth, proliferation and survival, and is required for tumour initiation and growth in mouse lung cancer models, whilst having little effect on the health of normal adult mice, establishing the significance of the p110α/KRAS interaction as an oncology drug target. Despite the weak binding affinity of the p110α/KRAS interaction (KD = 3 μM), the NBBA proved to be robust and displayed excellent Z'-factor statistics during the HTS primary screening of 726,000 compounds, which led to the identification of 8,000 active compounds. A concentration response screen comparing KRAS/p110α with two closely related PI3K isoforms, p110δ and p110γ, identified selective p110α-specific compounds and enabled derivation of an IC50 for these hits. We identified around 30 compounds showing greater than 20-fold selectivity towards p110α versus p110δ and p110γ with IC50 < 2 μM. By using Differential Scanning Fluorimetry (DSF) we confirmed several compounds that bind directly to purified p110α. The most potent hits will be followed up by co-crystallization with p110α to aid further elucidation of the nature of the interaction and extended optimisation of these compounds.
Additional file 4: of Professional learning needs in using video calls identified through workshops
Creators: name: Statton, Sarah
name: Jones, Ray
name: Thomas, Martin
name: North, Tracie
name: Endacott, Ruth
name: Frost, Adrian
name: Dazzle Tighe
name: Wilson, Gail
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: A step-by-step implementation guide to health professionals. (DOCX 22 kb)
Temporal association of ventricular arrhythmias and respiratory events in heart failure patients with central sleep apnoea
Creators: name: Guenzler, Valentin
name: Arzt, Michael
name: Grimm, Marjorie
name: Ebert, Amelie
name: Zeman, Florian
name: Linz, Dominik
name: Woehrle, Holger
name: Tamisier, Renaud
name: Cowie, Martin R.
name: Fisser, Christoph
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: 610 Medizin

description: In contrast to obstructive sleep apnoea, the peak of sympathetic tone in central sleep apnoea occurs during the hyperventilation phase. To explore the temporal association of premature ventricular complex (PVC) burden in the context of the apnoea/hypopnoea-hyperpnoea cycle, the duration of apnoea/hypopnoea was defined as 100 %. We assessed the PVC burden throughout the apnoea/hypopnoea-hyperpnoea cycle during the periods of ±150 % in 50 % increments before and after the apnoea/hypopnoea phase. In this subanalysis of 54 SERVE-HF patients, PVC burden was 32 % higher in the late hyperventilation period (50–100 % after apnoea/hypopnoea) compared to the apnoea/hypopnoea phase.
Efficacy of nutraceuticals (probiotics or prebiotics or synbiotics) in the prevention or treatment of COVID -19: a systematic review and meta-analysis
Creators: name: Sinha, Anju Pradhan
name: Khatib, Mahalaqua Nazli
name: Gaidhane, Abhay
name: Upadhyay, Shilpa
name: Wanjari, Mayur
name: Quazi, Syed Zahiruddin
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Nutraceuticals have generated an interest among clinicians for their applicability in the prevention and treatment of many ailments. Literature suggests the possible role of nutraceuticals in COVID-19. However, substantial uncertainty related to their safety and efficacy still exists. The aim of this study is to assess the efficacy and safety of nutraceuticals in preventing or treating COVID-19. We searched electronic databases, registries, websites, and e-libraries of development agencies. We included randomized controlled trials (RCTs), quasi-experiments, pre-post studies, and other experimental study designs. We assessed the risk of bias (RoB) using the RoB2 tool for RCTs and the ROBINS-I tool for non-RCTs. We assessed the overall certainty of the evidence using GRADEpro GDT. The outcomes assessed were the number of COVID-19 cases, change in disease severity, days of hospitalization, deaths, and adverse events. We performed the last search on 13th December 2023. After screening 481 studies, our analysis of five revealed one study with ‘low risk’ and four studies with ‘some concerns’ regarding bias. Our findings indicated that nutraceuticals did not significantly reduce COVID-19 mortality; their effect on hospitalization duration was uncertain. Furthermore, our assessment found no substantial evidence of increased adverse effects with probiotic use (RR 0.11, 95% CI 0.01 to 1.89, P = 0.13). Importantly, none of the studies investigated nutraceuticals’ preventive effects or their role in mitigating COVID-19 severity. There is limited evidence available on the use of nutraceuticals (probiotics, prebiotics, or synbiotics) for the treatment and prevention of COVID-19. Conducting methodologically robust RCTs with large population samples is recommended.PROSPERO REGISTRATION ID CRD42021284923
Diabetes & Dementia: A Health Study on the Risk Factors for Dementia in Individuals with Diabetes in the United States
Creators: name: Adjini, Maria Afi Enyonam
Publisher: name: Georgia State University
Year: 2024

description:
INTRODUCTION: Diabetes has been classified as one of the leading preventable risk factors for cognitive decline and further progression to dementia. Approximately 40% of all dementia cases can theoretically be prevented or at least delayed if certain risk factors in subjects with diabetes are eliminated. If risk factors for dementia in individuals with diabetes are targeted, it will lead to a decrease in the number of people with cognitive decline, and further reduce the prevalence of dementia in the coming years.


AIM: This study aims to investigate risk factors associated with cognitive decline in subjects with diabetes. METHODS: The study analyzed data from the Behavioral Risk Factor Surveillance System using a sample of 1,913 individuals with diabetes. We determined the association between various risk factors such as gender, BMI, physical activity, race/ethnicity, marital status, satisfaction with life, inability to afford a doctor, and depressive disorder diagnosis in subjects with diabetes. Odds ratios from the multivariable logistic regression models were used to estimate the degree of association. Statistical significance was established using 95% confidence intervals or p-value < 0.05.


RESULTS: Regular physical activity (OR = 0.70, 95% CI: 0.52  0.94, P = 0.018) and satisfaction with life (OR = 0.70, 95% CI: 0.52  0.94, P = 0.018) were associated with reduced odds for dementia. Individuals with a depressive disorder and those unable to afford to see a doctor had 1.59 and 1.97 higher odds of dementia than those who had no depression and could afford to see a doctor. Also, males had 7% reduced odds of dementia, and overweight or obese people had 1.35 higher odds for dementia. Moreover, non-Hispanic White individuals had higher odds of dementia compared to non-Hispanic Black and Hispanic individuals, and married people had reduced odds compared to divorced, never married, and widowed people. Unemployed individuals and those earning good income had higher odds of dementia than individuals who were employed for wages or self-employed and individuals earning low income.


CONCLUSION: These findings are crucial in terms of public health and call for public health practitioners to be aware of risk factors for cognitive decline and dementia in diabetes patients. Public health interventions can help reduce the prevalence of cognitive decline in diabetes patients by promoting physical activity, improving diet, and encouraging cognitively stimulating activities such as reading and social engagement.
Multimodal in-vehicle lighting system increases daytime light exposure and alertness in truck drivers under Arctic winter conditions
Creators: name: Popp, Roland F. J.
name: Ottersbach, Julia
name: Wetter, Thomas C.
name: Schüler, Sebastian
name: Rothe, Siegfried
name: Betz, Daniel
name: Staggl, Siegmund
name: Canazei, Markus
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: 610 Medizin

description: Drowsiness while driving negatively impacts road safety, especially in truck drivers. The present study investigated the feasibility and alerting effects of a daylight-supplementing in-truck lighting system (DS) providing short-wavelength enriched light before, during, and after driving. In a within-participants design, eight truck drivers drove a fully-loaded truck under wintry Scandinavian conditions (low daylight levels) with a DS or placebo system for five days. Subjective and objective measures of alertness were recorded several times daily, and evening melatonin levels were recorded three times per study condition. DS significantly increased daytime light exposure without causing negative side effects while driving. In addition, no negative carry-over effects were observed on evening melatonin and sleepiness levels or on nighttime sleep quality. Moreover, objective alertness (i.e., psychomotor vigilance) before and after driving was significantly improved by bright light exposure. This effect was accompanied by improved subjective alertness in the morning. This field study demonstrated that DS was able to increase daytime light exposure in low-daylight conditions and to improve alertness in truck drivers before and after driving (e.g., during driving rest periods). Further studies are warranted to investigate the effects of daylight-supplementing in-cabin lighting on driving performance and road safety measures.
Survey of Retail-Setting Corrective Statements in Fulton County, Georgia
Creators: name: Malarcher, Christopher
Publisher: name: Georgia State University
Year: 2024

description: 

Authors: Christopher Malarcher


Title: Tobacco Industry Corrective Statements in Retail Stores in Fulton County, Georgia


Background: In 2022, a federal court ordered the tobacco industry to display signs in retail stores featuring 17 corrective statements about the health effects and addictiveness of cigarette smoking. The order requires the statements to be randomly distributed and displayed in highly visible locations. The goal of the study was to examine whether the statements are correctly displayed.


Methods: One hundred retail stores in Fulton County, Georgia were randomly selected from the tobacco industrys list submitted to the Court. Surveyors visited the selected stores during February 2024 and used an electronic survey to abstract information on the statements and tobacco promotions and sales. Logistic regression models were used to examine whether the distribution of corrective statements varied by the proportion of residents who were African American and the percent of persons with incomes below the poverty level in the stores census tract using data from the 2020 Census.


Results: Ninety-one stores were able to be surveyed (58.2% were convenience stores). Interior signs were absent in 16.5% of the stores and 18.5% of the interior statements were not visible to the customer. Statements were randomly distributed across the stores (chi-squared p-value = 0.0613). However, statements on the health effects of smoking increased as the percentage of African Americans increased (Wald statistic p-value = 0.0343). Almost all stores had interior tobacco promotions (94.5%). In addition to cigarettes most stores also sold cigarillos (93.4%) and other tobacco products (68.1%).


Conclusions: There was high rate of noncompliance with the court-ordered corrective statements in Fulton County, Georgia. In addition, the relationship between the percent African Americans in the stores census tract and signs about smokings health effects may indicate non-random distribution. Tobacco promotions and sales were ubiquitous across all stores and likely significantly detracted from the visibility and impact of the corrective statements.
Care Pathway of People with Frontotemporal Dementia (FTD) Living in States that have Expanded Medicaid under ACA Vesus Those Living in States that have not.
Creators: name: Scipion, Catherine Esther Alexandra
Publisher: name: Georgia State University
Year: 2024

description:
INTRODUCTION: The care pathway of people with Frontotemporal Dementia (FTD) is strongly influenced by differences in health insurance coverage. Medicaid expansion under the Patient Protection and Affordable Care Act (ACA) has been demonstrated to impact the care pathway of adults with chronic conditions such as cancer, mental health disorders, and cardiovascular diseases. Yet, no study has focused on its impact on the care pathway of people with FTD. This study hypothesized that people living in states that have expanded Medicaid under ACA have better care pathway outcomes than their counterparts.


METHODS: I analyzed self-reported data of caregivers for people with FTD from the Association for Frontotemporal Dementia (AFTD) Insights Survey. Variables related to the care pathway included the diagnosis journey (defined by misdiagnosis and number of doctors consulted before FTD diagnosis was made), treatment of FTD symptoms (i.e., use of prescription and over-the-corner medications, cost-related drawbacks to prescription medications, and non-pharmacological management), and level of functional impairment as a proxy for quality of life. Individuals diagnosed with FTD were grouped based on the Medicaid expansion status of the state they lived in. I used Pearson chi-squared tests to compare the care pathway of individuals with FTD living in states based on their Medicaid expansion status at the time of their diagnosis. Statistical significance was defined as p-value < 0.05.


FINDINGS: People diagnosed with FTD in states with Medicaid expansion status had a better diagnosis journey. Specifically, in states with Medicaid expansion status, we observed the lowest proportion of people with FTD who experienced misdiagnosis (44.4%, p=0.04) and highest proportion who consulted only 1 or 2 doctors before FTD diagnosis was made (46.7%, p=0.04). However, other aspects of the care pathway, such as the experience of individuals related to the use of prescription medications (p=0.05), non-pharmacological management (p=0.7) to treat FTD, cost-related drawbacks to prescription medications (p=0.06), and the patients level of functional impairment (p=0.3) did not significantly differ across states based on their Medicaid expansion status.


CONCLUSION: This study demonstrated that, within their care pathway, the diagnosis journey of people with FTD was more favorable in states that expanded Medicaid under ACA. This study provides insights into the potential inequalities in the diagnosis journey of people with FTD associated with inconsistent health insurance coverage. Therefore, this study set the stage for future studies aimed at informing health policies to improve the diagnosis experiences of patients with FTD.
title: Protecting the climate through EU supply chain legislation? Two critiques and a compromise
Creators: name: Buser, Andreas
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Corporate sustainability due diligence
subject: climate accountability
subject: supply chain regulation
subject: regulatory imperialism
subject: international climate mitigation law
classificationCode: 340
subject: Recht

description: Climate change law faces a serious implementation problem. New instruments promoted by states from the Global North to address the implementation gap come from the sphere of trade and supply chain regulation. This article focuses on corporate climate due diligence legislation and its potential contribution to fulfilling the objectives outlined in the Paris Agreement. By examining the EU’s legislative process towards adopting a Corporate Sustainability Due Diligence Directive (CSDDD), it explores various approaches to regulating the climate impacts of corporations, including along global supply chains. The article critiques both the ultimately adopted climate transition planning requirement and the European Parliament’s alternative proposal, which aimed to incorporate climate mitigation into the general due diligence framework of the Directive but was unsuccessful. It applies two overarching critiques, termed ‘not enough’ and ‘regulatory imperialism’, to the specific context of corporate climate due diligence. Although these critiques may initially appear contradictory, the article endeavours to reconcile them through a compromise approach that fosters greater participation, integrates measures to mitigate impacts on self-determination, and specifies the obligations imposed on corporations regarding climate mitigation. Finally, the article discusses the idea of a decentralised enforcement regime and highlights the importance of regulation in states of the Global South to achieve a truly planetary legal order on corporate climate accountability.
title: ÐÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸ ÑÐ°Ð±Ð¾ÑÑ Ñ Ð¾Ð´Ð°ÑÐµÐ½Ð½ÑÐ¼Ð¸ Ð´ÐµÑÑÐ¼Ð¸ Ð½Ð° ÑÑÐ¾ÐºÐ°Ñ Ð°Ð½Ð³Ð»Ð¸Ð¹ÑÐºÐ¾Ð³Ð¾ ÑÐ·ÑÐºÐ°
title: Features of working with gifted children at the lessons of english
Creators: name: Ð¡Ð¾Ð½Ð¸Ð½Ð°, ÐÐ°ÑÐ°Ð»Ð¸Ñ
name: Ð¨Ð°ÑÐ¸Ð»Ð¾Ð²ÑÐºÐ¸Ðµ ÑÑÐµÐ½Ð¸Ñ
Publisher: name: ÐÐÐÐÐ¢ÐÐ¥-ÐÐ ÐÐ¡Ð¡
Year: 2024
Subjects: Ð¾Ð´Ð°ÑÐµÐ½Ð½ÑÐµ Ð´ÐµÑÐ¸
Ð¿ÑÐ¾ÑÐµÑÑ Ð¾Ð±ÑÑÐµÐ½Ð¸Ñ
Ð´Ð¸ÑÑÐµÑÐµÐ½ÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐµ Ð·Ð°Ð´Ð°Ð½Ð¸Ñ
ÑÐ¿Ð¾ÑÐ¾Ð±Ð½Ð¾ÑÑÐ¸
ÑÐ¸ÑÑÐµÐ¼Ð° ÐºÐ¾Ð½ÑÑÐ¾Ð»Ñ
gifted children
learning process
differentiated tasks
abilities
control system

description: Ð¡ÑÐ°ÑÑÑ Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÑÐ¼ Ð¾Ð±ÑÑÐµÐ½Ð¸Ñ Ð¾Ð´Ð°ÑÐµÐ½Ð½ÑÑ Ð´ÐµÑÐµÐ¹ Ð½Ð° ÑÑÐ¾ÐºÐ°Ñ Ð°Ð½Ð³Ð»Ð¸Ð¹ÑÐºÐ¾Ð³Ð¾ ÑÐ·ÑÐºÐ°. ÐÑÐ¾Ð±Ð¾Ðµ Ð²Ð½Ð¸Ð¼Ð°Ð½Ð¸Ðµ ÑÐ´ÐµÐ»ÐµÐ½Ð¾ ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ñ Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°ÑÐµÐ»ÑÐ½Ð¾Ð¹ ÑÑÐµÐ´Ñ, Ð½ÐµÐ¾Ð±ÑÐ¾Ð´Ð¸Ð¼Ð¾Ð¹ Ð´Ð»Ñ Ð²ÑÑÐ²Ð»ÐµÐ½Ð¸Ñ Ð¾Ð´Ð°ÑÐµÐ½Ð½ÑÑ Ð´ÐµÑÐµÐ¹ Ð¸ Ð¿Ð¾ÑÑÑÐ¾ÐµÐ½Ð¸Ñ ÑÐ¸ÑÑÐµÐ¼Ð°ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð¸ Ð¿Ð»Ð°Ð½Ð¾Ð¼ÐµÑÐ½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ Ñ Ð½Ð¸Ð¼Ð¸.
description: The article is devoted to the peculiarities of teaching gifted children at the lessons of English. Special attention is paid to the creation of an educational environment necessary to identify gifted children and build systematic work with them.
Additional file 7: Table S1. of Tasquinimod triggers an early change in the polarization of tumor associated macrophages in the tumor microenvironment
Creators: name: Olsson, Anders
name: NakhlĂŠ, Jessica
name: Sundstedt, Anette
name: Plas, Pascale
name: Anne-Laure Bauchet
name: ValĂŠrie Pierron
name: Bruetschy, Luce
name: Deronic, Adnan
name: TĂśrngren, Marie
name: Liberg, David
name: Schmidlin, Fabien
name: Leanderson, Tomas
Publisher: name: Figshare
Year: 2015
Subjects: subject: Space Science
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Average raw Ct values for the different genes analyzed in F4/80+ population using Syber Green Technology (PDF 29 kb)
Unicondylar knee arthroplasty demonstrating a significant increased risk for aseptic revisions compared to unconstrained and constrained total knee arthroplasty: An analysis of aseptic revisions after unicondylar and primary total knee arthroplasty of the German Arthroplasty Registry
Creators: name: Straub, Josina
name: Szymski, Dominik
name: Walter, Nike
name: Wu, Yinan
name: Melsheimer, Oliver
name: Grimberg, Alexander
name: Alt, Volker
name: Steinbrueck, Arnd
name: Rupp, Markus
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: aseptic revision, constrained, knee arthroplasty, register study, unconstrained, unicondylar
subject: 610 Medizin

description: Purpose

Due to ageing population, the implantation rate of total knee arthroplasties (TKAs) is continuously growing. Aseptic revisions in primary knee arthroplasty are a major cause of revision. The aim of the following study was to determinate the incidence and reasons of aseptic revisions in constrained and unconstrained TKA, as well as in unicondylar knee arthroplasties (UKAs).
Methods

Data collection was performed using the German Arthroplasty Registry. Reasons for aseptic revisions were calculated. Incidence and comparison of aseptic revisions were analysed using Kaplan–Meier estimates. A multiple χ2 test with Holm's method was used to detect group differences in ligament ruptures.
Results

Overall, 300,998 cases of knee arthroplasty with 254,144 (84.4%) unconstrained TKA, 9993 (3.3%) constrained TKA and 36,861 (12.3%) UKA were analysed. Aseptic revision rate in UKA was significantly increased compared to unconstrained and constrained TKA (p < 0.0001). In constrained TKA, a 2.0% revision rate for aseptic reasons were reported after 1 year, while in unconstrained TKA 1.1% and in UKA, 2.7% of revisions were identified. After 7 years in constrained TKA 3.3%, in unconstrained TKA 2.8%, and in UKA 7.8% sustained aseptic revision. Ligament instability was the leading cause of aseptic revision accounting for 13.7% in unconstrained TKA. In constrained TKA, 2.8% resulted in a revision due to ligament instability. In the UKA, the most frequent cause of revisions was tibial loosening, accounting for 14.6% of cases, while progression of osteoarthritis accounted for 7.9% of revisions. Ligament instability was observed in 14.1% of males compared to 15.9% of females in unconstrained TKA and in 4.6% in both genders in UKA.
Conclusion

In patients with UKA, aseptic revision rates are significantly higher compared to unconstrained and constrained TKA. Ligament instability was the leading cause of aseptic revision in unconstrained TKA. In UKA, the most frequent cause of revisions was tibial loosening, while progression of osteoarthritis was the second most frequent cause of revisions. Comparable levels of ligament instability were observed in both sexes.
Level of Evidence

Level III, cohort study.
Notoporus Schuster & Summers 1978
Creators: name: Halliday, R. B.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Mesostigmata
Diarthrophallidae
Notoporus

description: Notoporus Schuster & Summers, 1978
Notoporus Schuster & Summers, 1978: 309.
Type species Notoporus clypeolus Schuster & Summers, 1978: 309, by original designation.
description: Published as part of Halliday, R. B., 2015, Catalogue of genera and their type species in the mite Suborder Uropodina (Acari: Mesostigmata), pp. 101-147 in Zootaxa 3972 (2) on page 122, DOI: 10.11646/zootaxa.3972.2.1, http://zenodo.org/record/232777