cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
STUDIO DELL'EFFETTO DI UKRAIN SUI MECCANISMI DI TRANSIZIONE EPITELIO-MESENCHIMALE E INVASIVITA' TUMORALE IN CELLULE DI CARCINOMA RENALE
Creators: name: PETTINARI, LETIZIA
Publisher: name: Universit� degli Studi di Milano
Year: 2012

description: Renal cell carcinoma (RCC) is the most common malignancy of the kidney, arising from the cortical tubular epithelium and accounting for 85% of renal cancers. Recent clinical investigations suggested that Ukrain (UK), a semisynthetic derivative of the greater celandine alkaloids, exerts beneficial effects in the treatment of several solid tumors, including the RCC. In this study we investigated whether UK was able to modulate the malignant phenotype of RCC cells, by analyzing the expression of proteins involved in tumor progression. For this purpose, we investigated whether Ukrain modulates the malignant phenotype of clear cell renal carcinoma (ccRCC) cells Caki-1, Caki-2, ACHN treated with four doses (5, 10, 20, 40 �M) for 24 and 48h. The epithelial-to-mesenchymal transition (EMT) markers E-cadherin, ?-catenin, vimentin were analyzed by immunofluorescence, as well as actin and tubulin; matrix metalloproteinase-2 and -9 activity was analyzed by SDS-zymography, intracellular and secreted SPARC protein levels by Western blot, cell cycle by flow cytometry. Ukrain did not induce E-cadherin/?-catenin immunoreactivity at cell-cell boundary, although determined actin cortical expression in Caki-2 and ACHN, and did not affect vimentin organization; however, in some Caki-1 and ACHN cells the perinuclear concentration of vimentin was consistent with its down-regulation. Matrix metalloproteinase-2 and -9 activity was significantly down-regulated 48h after 20 �M Ukrain administration. At this time point Ukrain significantly decreased migration and invasion, and down-regulated SPARC levels in cell supernatants at all doses in Caki-2, and at 20 �M in Caki-1 and ACHN cells, possibly rendering tumor microenvironment less permissive for tumor invasion. Concomitantly, SPARC was up-regulated in all ccRCC cells, suggesting that Ukrain could also affect cell proliferation by cell cycle inhibition, as supported by the cell cycle analysis, since SPARC acts also as cell cycle inhibitor. Our results suggest that Ukrain may switch the EMT-related phenotype of ccRCC cells, and targets the two major aspects involved in RCC progression, such as tumor invasion/microenvironment remodeling and cell proliferation.
The red blazar PMN J2345-1555 becomes blue
Creators: name: Ghisellini, G.
name: Tavecchio, F.
name: Foschini, L.
name: Bonnoli, G.
name: Tagliaferri, G.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The Flat Spectrum Radio Quasar PMN J2345-1555 is a bright gamma-ray source, that recently underwent a flaring episode in the IR, UV and gamma-ray bands. The flux changed quasi simultaneously at different frequencies, suggesting that it was produced by a single population of emitting particles, hence by a single and well localized region of the jet. While the overall Spectral Energy Distribution (SED) before the flare was typical of powerful blazars (namely two broad humps peaking in the far IR and below 100 MeV bands, respectively), during the flare the peaks moved to the optical-UV and to energies larger than 1 GeV, to resemble low power BL Lac objects, even if the observed bolometric luminosity increased by more than one order of magnitude. We interpret this behavior as due to a change of the location of the emission region in the jet, from within the broad line region, to just outside. The corresponding decrease of the radiation energy density as seen in the comoving frame of the jet allowed the relativistic electrons to be accelerated to higher energies, and thus produce a "bluer" SED.
description: 5 pages, 4 figures, MNRAS Letters, in press
title: Μελέτη περιβαλλοντικών επιπτώσεων & επικινδυνότητας μονάδων παραγωγής συσσωρευτών
Creators: name: Κομνος Δημητριος
Publisher: name: Technical University of Crete
Year: 2016

description: Η αυξανόμενη χρήση μπαταριών (συσσωρευτών) τα τελευταία χρόνια οφείλεται στην ραγδαία ανάπτυξη των ανανεώσιμων πηγών ενέργειας και στην υιοθέτηση νέων πολιτικών, αναφορικά με τα καύσιμα, φιλικότερων προς το περιβάλλον. Η παραγωγή τους, όμως, πρέπει να γίνεται κάτω από συγκεκριμένα μέτρα ώστε οι μπαταρίες να μην αποτελούν κίνδυνο για την ζωή, την υγεία και το περιβάλλον αλλά να είναι απόλυτα εναρμονισμένες με την οικολογική συνείδηση. Αντικείμενο μελέτης, λοιπόν, της παρούσας εργασίας είναι ο εντοπισμός των κινδύνων αυτών και ο περιορισμός τους με την εφαρμογής κατάλληλων μέτρων.
Προηγείται η καταγραφή και ανάλυση των πηγών κινδύνου για το περιβάλλον και την ανθρώπινη υγεία ώστε να προσδιοριστεί με ακρίβεια το πρόβλημα. Εντοπίζονται οι αέριοι, υγροί και στερεοί ρύποι που προκύπτουν από μία μονάδα παραγωγής συσσωρευτών και παρουσιάζονται οι επιπτώσεις τους. Στη συνέχεια, γίνεται σύγκριση των εκπεμπόμενων ρύπων με τα αποδεκτά όρια όπως ορίζονται από την Ελληνική Δημοκρατία και την Ευρωπαϊκή Ένωση ώστε να προσδιοριστεί το μέγεθος του κινδύνου που πρέπει να περιοριστεί. Στην παραπάνω καταγραφή προσδιορίζονται επίσης και οι εργονομικοί κίνδυνοι ώστε να ακολουθήσει μία μελέτη επικινδυνότητας για τον χώρο εργασίας της μονάδας παραγωγής συσσωρευτών.
Το δεύτερο σκέλος της εργασία αφορά τους τρόπους αντιμετώπισης του προβλήματος που αναλύθηκε προηγουμένως. Ως λύσεις παρουσιάζονται μονάδες εξουδετέρωσης και απομόνωσης των ρύπων, όπως η μονάδα επεξεργασίας λυμάτων και η πλυντηρίδα αερίων. Προτείνονται μέτρα προστασίας των εργαζομένων και μέτρα περιορισμού του ρυπαντικού φορτίου προς το περιβάλλον. Με στόχο της πρακτική και εφαρμοσμένη προσέγγιση του θέματος η εργασία θα στηριχθεί σε πραγματικά δεδομένα μονάδας παραγωγής συσσωρευτών.
Felsburgen im Oberen Donautal. Mitglieder der Landesgruppe Baden-Württemberg im Dienste der Inventarisation schwer zugänglicher Ruinen
Creators: name: Pfefferkorn, Wilfried
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2017

description: -
description: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 15, Nr. 1 (1974): Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
title: Συναρμολογούμενο υδροπονικό σύστημα εκτυπώσιμο σε τρισδιάστατο εκτυπωτή
title: Modular hydroponic system printable in 3D printer
Creators: name: Αρλαπανος Δημητριος
Publisher: name: Technical University of Crete
Year: 2016

description: Σχεδιασμός υδροπονικού συστήματος αποτελούμενο από 6 εξαρτήματα,τα οποία μπορούν να τυπωθούν σε τρισδιάστατο εκτυπωτη. Αναφορά στα 2 πρώτα κεφάλαια στην υδροπονία και τους τρισδιάστατους εκτυπωτές, και στο τρίτο η ανάλυση του συστήματος και των εξαρτημάτων
NUTRITIONAL STATUS, ENERGY REQUIREMENTS AND METABOLIC MONITORING IN CRITICALLY ILL CHILDREN: THE NEW PERSPECTIVE OF ARTIFICIAL NEURAL NETWORKS
Creators: name: SPOLIDORO, GIULIA CARLA IMMACOLATA
Publisher: name: Universit� degli Studi di Milano
Year: 2021

description: Nutrition plays a pivotal role in all humans. As early as during foetal life, a correct nutrition has the power to influence the development of organs and tissues, ultimately setting the basis for a healthy life. In critically ill children the risk of malnutrition is of particular importance. Accordingly, an appropriate monitoring of nutritional status and metabolic response, along with the correct assessment of energy requirements and energy balance, is gaining growing clinical relevance as a fundamental prognostic factor and should be considered a specific target in the management of critically ill children. The first step for a tailored nutritional support is the knowledge of patients? resting energy expenditure (REE). Indirect calorimetry (IC) is the gold standard for REE measurement, however, its clinical use is limited across the world for both logistic and technical limitations. Alternatively, REE can be estimated using predictive equations, but this method has been found to be highly inaccurate in pediatric patients. Recent data pointed out that artificial neural networks (ANN) might represent a precise and accurate method to estimate REE in healthy and obese children. However, specific data regarding the applicability of the methodology on critically ill subjects are still missing. This thesis aimed to investigate the potential role of ANN on REE prediction for critically ill children by applying ANN to a dataset containing data on IC performed in our pediatric intensive care unit (PICU). We prospect that data derived from our observations could lead to a more accurate estimation of REE and to a better understanding of the energy requirements of critically ill children.
Das Leben auf Burgen im Spiegel mittelalterlicher Literatur (II. Teil)
Creators: name: Knappe, Karl-Bernhard
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2017

description: -
description: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 15, Nr. 2 (1974): Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
Additional file 2 of MicroRNA-1 attenuates the growth and metastasis of small cell lung cancer through CXCR4/FOXM1/RRM2 axis
Creators: name: Khan, Parvez
name: Siddiqui, Jawed Akhtar
name: Kshirsagar, Prakash G.
name: Venkata, Ramakanth Chirravuri
name: Maurya, Shailendra Kumar
name: Mirzapoiazova, Tamara
name: Perumal, Naveenkumar
name: Chaudhary, Sanjib
name: Kanchan, Ranjana Kumari
name: Fatima, Mahek
name: Khan, Md Arafat
name: Rehman, Asad Ur
name: Lakshmanan, Imayavaramban
name: Mahapatra, Sidharth
name: Talmon, Geoffrey A.
name: Kulkarni, Prakash
name: Ganti, Apar K.
name: Jain, Maneesh
name: Salgia, Ravi
name: Batra, Surinder Kumar
name: Nasser, Mohd Wasim
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 2.
title: The effective integration of 3D virtual prototype in the product development process of the textile/clothing industry
title: Αποτελεσματική ενσωμάτωση του 3D εικονικού πρωτότυπου στην διαδικασία ανάπτυξης προϊόντων της βιομηχανίας της κλωστοϋφαντουργίας & ένδυσης
Creators: name: Παπαχρηστου Ευρυδικη
Publisher: name: Technical University of Crete
Year: 2016

description: The Textile, Clothing and Fashion Sector (TCF), is one of the first industries to be importantly affected by the globalisation of production and services. The clothing industry is driven towards a permanently accelerating fashion, offering its products faster, cheaper, and in bigger abundance than ever. This demand has resulted in the search of new techniques that will add value in the product development process.
The present research’s scope is the study and acceptance of digital prototype as mean of communication and abbreviation of product development time without problems, decreasing the technological gap and the time of production, increasing at the same time the creativity and the direct visualisation of clothes and its application.
Digital prototype has become acceptable in the electromechanical products applications and several studies have revealed the most optimal exploitation of new technologies’ possibilities and the problems raised from its integration in the development process. In the TCF sector, the research is directed towards the development of plan study solutions with the aim of an emerged satisfactory digital prototype model that could integrate into the existing designing solutions.
Τhe objective of this research study is to give prominence to the integration demands and requirements as well as the effective use of digital three-dimensional model in the fashion process via extensive research of academics, technology vendors, users, designers and experts in clothing and fashion products.
'UOMINI E NO' DI ELIO VITTORINI. IL TESTO TRA CARTE E POETICA, TRA EDIZIONI E CRITICA.
Creators: name: BRIGATTI, VIRNA
Publisher: name: Universit� degli Studi di Milano
Year: 2013

description: This dissertation concerns the Elio Vittorini?s novel, Uomini e no (1945), examined from a new point of view introduced by the philological analysis of writer?s hand written papers and the page-proofs of the first edition, corrected by the author. Till now, all these documents has been neglected by the critics, but they allow us to study the creative process that leads to the texts edited the first time in 1945. We can show therefore the transformations of the characters? features and the evolution of the plot. The following part of the dissertation is dedicated to study Vittorini?s literature conception and her modifications during the 1940s, especially during the years immediately after the Second World War. These modifications leads the writer to a new edition of the novel, published in 1949, very different in comparison with the first one. This dissertation ends with the textual analysis of the 1949?s edition.
title: Μέτρηση της ευελιξίας μηχανής και δρομολόγησης σε δίκτυα παραγωγής
Creators: name: Δημητρελλος Ανδρεας
Publisher: name: Technical University of Crete
Year: 2016

description: Η διπλωματική εργασία επικεντρώνεται στη μελέτη της βιομηχανικής ευελιξίας μέσα απο την κατασκευή και εκτέλεση κατάλληλων μοντέλων προσομοίωσης στο πρόγραμμα της Matlab με χρήση της Simulink. Αρχικά, θα διερευνηθούν οι παράμετροι και ο τρόπος που αυτές επηρεάζουν την ευελιξία ενός σταθμού εργασίας και κατ' επέκταση της γραμμής παραγωγής σαν σύνολο. Τέλος θα διερευνηθούν οι παράμετροι που επηρεάζουν την ευελιξία δρομολόγησης μέσα απο προσομοιώσεις διαφορετικών σε πολυπλοκότητα δικτύων παραγωγής.
title: Μελέτη και αξιολόγηση τεχνικών τρισδιάστατης μοντελοποίησης χαμηλού κόστους
Creators: name: Μακατουνακης Χαραλαμπος
Publisher: name: Technical University of Crete
Year: 2016

description: Η εργασία αυτή έχει σκοπό την παρουσίαση της οικονομικής μεθόδου τρισδιάστατης μοντελοποίησης μέσω φωτογραφιών  και τη σύγκριση της με τη μέθοδο μοντελοποίησης  με χρήση σαρωτή λευκού φωτός. Δομείται σε πέντε κεφάλαια. Το πρώτο και το δεύτερο αφορούν μια εισαγωγή στις έννοιες και τις μεθόδους της  τρισδιάστατης μοντελοποίησης και τη παρουσίαση της μεθόδου που μας απασχολεί σε θεωρητικό επίπεδο. Το τρίτο κεφάλαιο αποτελεί την παρουσίαση του λογισμικού που χρησιμοποιήθηκε για την εξαγωγή των μοντέλων και το τέταρτο, την αναλυτική διαδικασία της σύγκρισης των μεθόδων που ακολουθήσαμε. Στο πέμπτο κεφάλαιο βρίσκονται τα συμπεράσματα που εξήχθησαν από τα αποτελέσματα της σύγκρισης.
Burgen und Schlösser um Cham. Ein Skizzenbuch um 1860
Creators: name: Werner, Günther Trautwin
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2017

description: -
description: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 17, Nr. 2 (1976): Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
Liegt Schilda in der Oberpfalz?
Creators: name: Kunze, Rainer
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2017

description: -
description: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 17, Nr. 2 (1976): Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
Anti-Evaporation of Schwarzschild-de Sitter Black Holes in $F(R)$ gravity
Creators: name: Nojiri, Shin'ichi
name: Odintsov, Sergei D.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We studied the anti-evaporation of degenerate Schwarzschild-de Sitter black hole (so-called Nariai space-time) in modified $F(R)$ gravity. The analysis of perturbations of the Nariai black hole is done with the conclusion that anti-evaporation may occur in such a theory already on classical level. For several power-law $F(R)$ gravities which may describe the inflation and/or dark energy eras we presented the theory parameters bounds for occurrence of anti-evaporation and conjectured creation of infinite number of horizons.
description: LaTeX 6 pages, no figure, discussion enlarged, misprints are corrected
Supplementary Materials from Molecular-scale substrate anisotropy, crowding and division drive collective behaviours in cell monolayers
Creators: name: Luo, Yimin
name: Gu, Mengyang
name: Park, Minwook
name: Fang, Xinyi
name: Kwon, Younghoon
name: Urueña, Juan Manuel
name: Read de Alaniz, Javier
name: Helgeson, Matthew E.
name: Marchetti, Cristina M.
name: Valentine, Megan T.
Publisher: name: The Royal Society
Year: 2023
Subjects: subject: Biophysics
subject: 90301 Biomaterials
subject: FOS: Medical engineering

description: The ability of cells to reorganize in response to external stimuli is important in areas ranging from morphogenesis to tissue engineering. While nematic order is common in biological tissues, it typically only extends to small regions of cells interacting via steric repulsion. On isotropic substrates, elongated cells can co-align due to steric effects, forming ordered but randomly oriented finite-size domains. However, we have discovered that flat substrates with nematic order can induce global nematic alignment of dense, spindle-like cells, thereby influencing cell organization and collective motion and driving alignment on the scale of the entire tissue. Remarkably, single cells are not sensitive to the substrate’s anisotropy. Rather, the emergence of global nematic order is a collective phenomenon that requires both steric effects and molecular-scale anisotropy of the substrate. To quantify the rich set of behaviours afforded by this system, we analyse velocity, positional and orientational correlations for several thousand cells over days. The establishment of global order is facilitated by enhanced cell division along the substrate’s nematic axis, and associated extensile stresses that restructure the cells’ actomyosin networks. Our work provides a new understanding of the dynamics of cellular remodelling and organization among weakly interacting cells.
Barocke Dachwerke, Decken und Gewölbe
Creators: name: Fink, Otto
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2017

description: Rezension zu: Hans-Joachim Sachse: Barocke Dachwerke, Decken und Gewölbe. Zur Baugeschichte und Baukonstruktion in Süddeutschland, Berlin (Gebr. Mann Verlag) 1975, 152 S., darin 9 Risse, 292 Abb. auf 88 Tafeln, 2 Falttafeln (karton.).
description: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 17, Nr. 2 (1976): Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
TREATMENT OF ACUTE CORONARY SYNDROMES IN OLDER ADULTS
Creators: name: MORICI, NUCCIA
Publisher: name: Universit� degli Studi di Milano
Year: 2021

description: Background Despite the increased proportion of elderly patients among those admitted for an acute coronary syndrome (ACS), elderly population has been underrepresented in prospective studies and randomized clinical trials. Nevertheless, older people are often frail, which means that they have low reserve capacity and decreased ability to manage complex physiologic stress, with a significant multimorbidity burden. Accordingly, they deserve dedicated studies to better improve clinical decision making in daily practice. Aim To provide additional information on risk factors and prognosis of elderly patients admitted to hospital for an ACS. Methods The project was based on three post-hoc analyses of the Elderly ACS 2 Randomized Trial- NCT01777503. The trial included ACS patients aged?75 years and aimed to compare clopidogrel versus prasugrel 5 mg on top of acetyl salicylic acid for long term secondary prevention and bleeding events. Three main research questions (RQ) were addressed: 1) the role of a specific inflammatory disease (psoriasis) as risk factor for ACS, evaluated within a case-control study; 2) the role of ST-segment elevation myocardial infarction (STEMI) as presenting ACS type as risk factor for cardiovascular, non-cardiovascular death and stroke, evaluated through a cohort study with competing risk analysis; 3) the role of the residual angiographic burden (after percutaneous coronary intervention-PCI) in predicting 1-year mortality and cardiovascular events, evaluated through the change in net benefit (NB) over a core prediction model including the most relevant clinical variables and basal angiographic burden. Results RQ1: The prevalence of psoriasis was lower among cases (12/1455, 0.8%) than among controls (18/1108, 1.6%). The multivariate OR of ACS according to history of psoriasis (adjusted for age, sex and smoking) was 0.51 (95% confidence interval: 0.23?1.09). RQ2: Patients with STEMI had a higher risk of cardiovascular death (cause-specific hazard ratio, cHR 1.85; 95% confidence interval, CI: 1.02-3.36), non-cardiovascular death (cHR 2.10; 95% CI, 1.01-4.38), and stroke (cHR 4.8; 95% CI, 1.7-13.7) as compared to patients with NSTEMI. RQ3: The inclusion of angiographic residual burden gave little incremental value in the standardized NB compared to the core model. Conclusions Our data does not support an association between psoriasis and risk of ACS in the elderly. In these patients, STEMI is an important predictor of cardiovascular death, non-cardiovascular death and stroke. The residual angiographic burden does not improve 1-year prediction of adverse outcome compared with a model including clinical variables and the basal angiographic burden. Elderly patients are a heterogenous, complex, and high- risk group whose management requires a multidimensional clinical approach beyond coronary anatomic variables.
METAL-CATALYZED SYNTHESIS OF POLYCYCLIC INDOLES
Creators: name: BRAMBILLA, ELISA
Publisher: name: Universit� degli Studi di Milano
Year: 2021

description: The indole core is ubiquitous in bioactive natural products and pharmaceutical compounds and the chemistry of the indole nucleus is the subject of intense investigations both for the synthesis of the indole core and the functionalization at both pyrrole and benzene moieties. One of the most employed building blocks is 2-vinylindole that pertains to the class of heterocyclic internal-external ring dienes, a useful class of molecules able to take part in cycloadditions with various dienophiles providing an easy access to poly(hetero)cycles. Another interesting compound, is 4H-furo[3,2-b]indoles presenting the peculiar structure of 4?-system embedded in the furan ring, leading to an increase of reactivity in comparison to 2-vinylindole congeners. Thus, potentially, 4H-furo[3,2-b]indoles could take part in different cycloaddition reactions as dienes when employed in [4+2] or (4+3) cyclizations or as dienophilic partners in [2+2] reactions with the C1-C2 double bond of the furan moiety. Furthermore, the C2 carbon of furan shows nucleophilic properties and can participate in simple functionalization reactions with different electrophiles. Moreover, as reported for simple furan derivatives, the addition of an electrophile at C2 can be followed by rearrangement processes that include a ring opening step. Thus the thesis is focused on the synthesis of different functionalized 4H-furo[3,2-b]indoles and on the study of their reactivity in the presence of different electrophilic partners. In detail, the obtained results belong to three main research topics: the first part was focused on the gold activation of different ? systems for the synthesis of indole derivatives from 4H-furo[3,2-b]indoles. In particular, it reports the cationic gold(I) catalyzed cascade reactions of 4H-furo[3,2-b]indoles with allenamides for the synthesis of spiropseudo-indoxyls. Successively, the activation of propargyl esters by gold(I) catalysts led to the synthesis of 2-alkenylidene-3-oxoindoles in a process that included a furan ring rearrangement. The second part reports the behavior of 4H-furo[3,2-b]indoles in the presence of a different electrophile, a copper(I) carbene, obtained from the in situ decomposition of a diazo compound under copper catalysis. The reaction allowed for the formation of a homologous series of the previously cited 2-alkenylidene-3-oxoindoles presenting a less extended conjugate system. The last part is focused on the in situ generation of an oxyallyl cation in order to study the performance of 4H-furo[3,2-b]indoles in (4+3) cycloaddition reactions. In this case, the electrophile was obtained from a ?-haloketone under basic condition and then reacted with both 2-vinylindoles and 4H-furo[3,2-b]. In addition, some preliminary results on the study of the reactivity of benzo[c]isoxazoles (anthranils) under basic condition for the synthesis of 2-hydrazineylisophthalaldehydes were conducted.
EVOLUTION EQUATIONS WITH APPLICATIONS TO POPULATION DYNAMICS
Creators: name: AFFILI, ELISA
Publisher: name: Universit� degli Studi di Milano
Year: 2021

description: The main topic of this thesis is the analysis of evolution equations reflecting issues in ecology and population dynamics. In mathematical modelling, the impact of environmental elements and the interaction between species is read into the role of heterogeneity in equations and interactions in coupled systems. In this direction, we investigate three separate problems, each corresponding to a chapter of this thesis. The first problem addresses the evolution of a single population living in a periodic medium with a fast diffusion line; this corresponds to the study of a reaction-diffusion system with equations in different dimensions. We derive results on asymptotic behaviour through the study of some generalised principal eigenvalues. We find that the road has no impact on the survival chances of the population, despite the deleterious effect expected from fragmentation. The second investigation regards a model describing the competition between two populations in a situation of asymmetrically aggressive interactions; this consists of a system of two ODEs. The evolution progresses through two possible scenarios, where only one population survives. Then, the interpretation of one of the parameters as the aggressiveness of the attacker population naturally raises questions of controllability. We characterise the set of initial conditions leading to the victory of the attacker through a suitable (possibly time-dependant) strategy. The third and last part of this thesis analyses the time decay of some evolution equations with classical and fractional time derivatives. Depending on the type of derivative and some degree of non-degeneracy of the spatial operator, quantitative polynomial or exponential estimates are entailed.
The Hierarchical Origins of Observed Galaxy Morphology
Creators: name: Wilman, David J.
name: Fontanot, Fabio
name: De Lucia, Gabriella
name: Erwin, Peter
name: Monaco, Pierluigi
Publisher: name: arXiv
Year: 2013
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Galaxies grow primarily via accretion-driven star formation in discs and merger-driven growth of bulges. These processes are implicit in semi-analytical models of galaxy formation, with bulge growth in particular relating directly to the hierarchical build-up of halos and their galaxies. In this paper, we consider several implementations of two semi-analytical models. Focusing on implementations in which bulges are formed during mergers only, we examine the fractions of elliptical galaxies and both passive and star-forming disk galaxies as functions of stellar and halo mass, for central and satellite systems. This is compared to an observational cross-matched SDSS+RC3 z ~ 0 sample of galaxies with accurate visual morphological classifications and M_{stellar} > 10^10.5 M_{sol}. The models qualitatively reproduce the observed increase of elliptical fraction with stellar mass, and with halo mass for central galaxies, supporting the idea that observed ellipticals form during major mergers. However, the overall elliptical fraction produced by the models is much too high compared with the z ~ 0 data. Since the "passive" -- i.e. non-star-forming -- fractions are approximately reproduced, and since the fraction which are star-forming disc galaxies is also reproduced, the problem is that the models overproduce ellipticals at the expense of passive S0 and spiral galaxies. Bulge-growth implementations (tuned to reproduce simulations) which allow the survival of residual discs in major mergers still destroy too much of the disc. Increasing the lifetime of satellites, or allowing significant disc regrowth around merger remnants, merely increases the fraction of star-forming disc galaxies. Instead, it seems necessary to reduce the mass ratios of merging galaxies, so that most mergers produce modest bulge growth in disc-galaxy remnants instead of ellipticals. [Abridged]
description: latex, 20 pages, 13 figures. Accepted by Monthly Notices. Source package includes full version of Table 1 from paper (file sdssrc3_table_for_paper.tab)
Militär und Technik — Schwedenfestungen  des 17. Jahrhunderts in den Herzogtümern Bremen und Verden
Creators: name: Fink, Otto
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2017

description: Rezension zu: Henning Eichberg: Militär und Technik — Schwedenfestungen  des 17. Jahrhunderts in den Herzogtümern Bremen und Verden, Düsseldorf (Pädagogischer Verlag Schwann) 1976, 331 S., 34 Repros, hist. Pläne und Risse, 2 Karten im Text.
description: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 18, Nr. 1 (1977): Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
Additional file 2 of Mitochondrial impairment and synaptic dysfunction are associated with neurological defects in iPSCs-derived cortical neurons of MERRF patients
Creators: name: Wu, Yu-Ting
name: Tay, Hui-Yi
name: Yang, Jung-Tse
name: Liao, Hsiao-Hui
name: Ma, Yi-Shing
name: Wei, Yau-Huei
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Mental Health

description: Additional file 2: Figure S1. Decreased density of synaptic vesicle in the axon of neurons derived from MERRF-iPSCs harboring the m.8344A > G mutation. Distribution of synaptic vesicle in neurons 3 weeks after differentiation was analyzed by the immunofluorescence staining with antibodies against synaptophysin (red), Tuj1 (green), and Hoechst 33342 (blue). Scale bars, 20 μm.
Additional file 1 of Development of the gut microbiota during early life in premature and term infants
Creators: name: Sim, Kathleen
name: Powell, Elizabeth
name: Cornwell, Emma
name: Simon Kroll, J.
name: Shaw, Alexander G.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Figure S1. Sequencing read counts by sample prior to rarefaction. Figure S2. Shannon Diversity Index for a randomly selected 79 samples (50% of the dataset) at a range of read depths. Table S1. Bacterial OTUs that are significantly associated with gestational age at 6 weeks of age. Table S2. Associations between bacterial phyla and gestational age at 6 weeks of age. Table S3. OTUs and their associated clinical factors at 6 weeks of age. Table S4. Phyla and their associated clinical factors at 6 weeks of age. Table S5. Bacterial OTUs that are significantly associated with gestational age at 2 years of age. Table S6. Associations between bacterial phyla and gestational age at 2 years of age. Table S7. OTUs and their associated clinical factors at 2 years of age. Table S8. Phyla and their associated clinical factors at 2 years of age.
The Black Hole Spin and Soft X-ray Excess of the Luminous Seyfert Galaxy Fairall 9
Creators: name: Lohfink, Anne M.
name: Reynolds, Christopher S.
name: Miller, Jon M.
name: Brenneman, Laura W.
name: Mushotzky, Richard F.
name: Nowak, Michael A.
name: Fabian, Andrew C.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present an analysis of all XMM-Newton and Suzaku X-ray spectra of the nearby luminous Seyfert galaxy Fairall 9. Confirming previous analyses, we find robust evidence for a broad iron line associated with X-ray reflection from the innermost accretion disk. By fitting a spectral model that includes a relativistically ionized reflection component, we examine the constraints on the inclination of the inner accretion disk and the black hole spin, and the complications introduced by the presence of a photoionized emission line system. Employing multi-epoch fitting, we attempt to obtain robust and concordant measures of the accretion disk parameters. We also clearly see a soft X-ray excess in Fairall 9. During certain epochs, the soft excess can be described with same disk reflection component that produces the iron line. However, there are epochs where an additional soft component is required. This can be attributed to either an additional highly-ionized, strongly blurred disk reflection component, or a new X-ray continuum component.
description: Accepted for publication in ApJ
Knowledge, attitude, and practices of community pharmacy staff toward antimicrobial stewardship programs: a cross-sectional study from Northeastern China
Creators: name: Feng, Zhitong
name: Hayat, Khezar
name: Huang, Zhe
name: Shi, Li
name: Li, Pengchao
name: Xiang, Cheng
name: Gong, Yilin
name: Chang, Jie
name: Jiang, Minghuan
name: Yang, Caijun
name: Zhao, Mingyue
name: Ji, Wenjing
name: Fang, Yu
Publisher: name: Taylor & Francis
Year: 2020
Subjects: Pharmacology
Biotechnology
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Science Policy
Virology

description: Antimicrobial resistance is one of the most significant challenges of the twenty-first century, and the illegal sale of antimicrobial drugs at community pharmacies is a driver of antimicrobial resistance. This study explores the knowledge, attitudes, and practices (KAP) of pharmacy staff toward antimicrobial stewardship programs (ASPs). We conducted a descriptive cross-sectional study among community pharmacy staff in Northeastern China, from April 1 to 31 May 2019, using a self-administered KAP questionnaire comprising 20 items. The data analysis was carried out by employing Mann-Whitney and Kruskal-Wallis tests. A response rate of 98.5% (394/400) was obtained. The majority of participants (94.9%) demonstrated a good understanding of antimicrobial use, but they lacked an adequate understanding of ASPs. Nearly half of the participants (40.6%) reported that they sold antimicrobials to patients without a prescription. Education level, age, occupation, and experience were all significantly associated (P < 0.05) with participants’ median ASPs scores. Besides, the presence of a licensed pharmacist (OR 46.327, 95% CI 2.443–878.451, P = 0.011) was the main factor associated with the pharmacy staff’s understanding of antimicrobial use policies. The participants’ knowledge of antimicrobials was good, and their attitudes regarding ASPs were positive, but their practices regarding ASPs were poor.
title: Political Pilgrimage during China’s Cultural Revolution: The Case of Dazhai
Creators: name: McIntosh, Ian S
Publisher: name: Technological University Dublin
Year: 2018

description: During China’s Cultural Revolution (1966-76) political pilgrimage was a tool for promoting the communist ideal of collectivism. This paper explores the creation in the 1960s by Chairman Mao Zedong of one of the foremost sites of political pilgrimage, the small agricultural commune of Dazhai in north-central China. I argue that in the days of militant atheism, all the factors usually associated with the creation of a religious pilgrimage site were present and utilized to great effect by the communists to create a ‘super symbol’ of China’s desired future. These factors included a miracle, charismatic leadership, altruism, poignant sites of historical significance, rituals of remembrance, and a sacred mission that would inspire the impoverished Chinese masses to strive unceasingly towards the revolution’s goals. Through careful marketing (and propaganda), national leaders sold the Dazhai story to the Chinese people through political speeches and media reporting, and persuasive posters, banners and songs. At its peak, millions of peasants visited the commune, either voluntarily or at the invitation of the state, to learn about Dazhai’s agricultural techniques and the peoples’ spirit of self-sacrifice. In this paper, I describe my own visit to Dazhai from Australia in 1977 and speculate on the long-term legacy of the Dazhai agricultural experiment, and of this political pilgrimage. In contemporary Dazhai, tourists have the opportunity to reflect on the commune’s heroic past, but also to consider the environmental damage caused by a model of development that was rich in revolutionary zeal but poor in science.
Keltischer Schiffbau
Creators: name: Ellmers, Detlev
Publisher: name: Verlag des Römisch-Germanischen Zentralmuseums Mainz
Year: 2017
Subjects: Eisenzeit; Latènezeit; Mitteleuropa; Schiffbau

description: [nicht vorhanden / not available]
description: Jahrbuch des Römisch-Germanischen Zentralmuseums Mainz, Bd. 16 (1969)
title: Project report NOAA Ship Oscar Elton Sette, Project SE-19-02 (MHI: Legs I – III)
titleType: Other
Creators: name: United States. National Marine Fisheries Service
name: Pacific Islands Fisheries Science Center (U.S.)
Publisher: name: United States. National Marine Fisheries Service. Pacific Islands Fisheries Science Center (U.S.)
Year: 2019

description: PIFSC project report ; Project SE-19-02
Additional file 1 of Detecting subtle signs of depression with automated speech analysis in a non-clinical sample
Creators: name: König, Alexandra
name: Tröger, Johannes
name: Mallick, Elisa
name: Mina, Mario
name: Linz, Nicklas
name: Wagnon, Carole
name: Karbach, Julia
name: Kuhn, Caroline
name: Peter, Jessica
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: Additional file 1:Table S1. Overview of extracted speech features. Table S2. Overview of extracted transcript features.
Impulsive correction to the elastic moduli obtained using the stress-fluctuation formalism in systems with truncated pair potential
Creators: name: Xu, H.
name: Wittmer, J. P.
name: Polińska, P.
name: Baschnagel, J.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The truncation of a pair potential at a distance r_cut is well-known to imply in general an impulsive correction to the pressure and other moments of the first derivatives of the potential. That depending on r_cut the truncation may also be of relevance to higher derivatives is shown theoretically for the Born contributions to the elastic moduli obtained using the stress-fluctuation formalism in d dimensions. Focusing on isotropic liquids for which the shear modulus G must vanish by construction, the predicted corrections are tested numerically for binary mixtures and polydisperse Lennard-Jones beads in, respectively, d=3 and d=2 dimensions.
Beobachtungen an Getreidekörnern in Töpferton
Creators: name: Hopf, Maria
Publisher: name: Verlag des Römisch-Germanischen Zentralmuseums Mainz
Year: 2017
Subjects: Vor- und Frühgeschichte; Keramik; Getreide; Versuche

description: [nicht vorhanden / not available]
description: Jahrbuch des Römisch-Germanischen Zentralmuseums Mainz, Bd. 16 (1969)
Exploring Aegyptiaca and their Material Agency throughout Global History
Creators: name: Versluys, Miguel John
Publisher: name: Aegyptiaca. Journal of the History of Reception of Ancient Egypt
Year: 2017

description: [nicht vorhanden / not available]
description: Aegyptiaca. Journal of the History of Reception of Ancient Egypt, Nr. 1 (2017): Aegyptiaca. History of Recepiton of Ancient Egypt
Professor Dr. Ing. Hans Spiegel 80 Jahre 1893-1973
Creators: name: Redaktion, Die
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2017

description: -
description: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 14, Nr. 1 (1973): Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
Tuning electronic structures via epitaxial strain in Sr2IrO4 thin films
Creators: name: Nichols, J.
name: Terzic, J.
name: Bittle, E. G.
name: Korneta, O. B.
name: De Long, L. E.
name: Brill, J. W.
name: Cao, G.
name: Seo, S. S. A.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We have synthesized epitaxial Sr2IrO4 thin-films on various substrates and studied their electronic structures as a function of lattice-strains. Under tensile (compressive) strains, increased (decreased) Ir-O-Ir bond-angles are expected to result in increased (decreased) electronic bandwidths. However, we have observed that the two optical absorption peaks near 0.5 eV and 1.0 eV are shifted to higher (lower) energies under tensile (compressive) strains, indicating that the electronic-correlation energy is also affected by in-plane lattice-strains. The effective tuning of electronic structures under lattice-modification provides an important insight into the physics driven by the coexisting strong spin-orbit coupling and electronic correlation.
description: 9 pages, 5 figures, 1 table
Internationales Burgeninstitut (IBI). Bericht über den XII. Kongreß des wissenschaftlichen Beirats in Warschau und Krakau, 14.-21. September 1972
Creators: name: Meyer, Werner
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2017

description: -
description: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 14, Nr. 1 (1973): Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
Wanderungen zu den Burgen und Domen am Rhein
Creators: name: Fink, Otto
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2017

description: Rezension zu: Hans-Heinrich Welchert: Wanderungen zu den Burgen und Domen am Rhein, Tübingen (Rainer Wunderlich Verlag, Hermann Leins) 1970, 256 S., 16 Bildtafeln, 13 Vignetten, farbiger Schutzumschlag, Ganzleinen.
description: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 15, Nr. 1 (1974): Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
title: Σύστημα απεικόνισης των αγγείων για την διευκόλυνση της αιμοληψίας
Creators: name: Κουρουπακης Δημητριος
Publisher: name: Technical University of Crete
Year: 2016

description:      Η διπλωματική εργασία αυτή έχει σχέση με την δημιουργία ενός συστήματος για την απεικόνιση των αγγείων, με την χρήση υπέρυθρων ακτίνων με σκοπό την βελτίωση της ακρίβειας της αιμοληψίας. Οι υπέρυθρες ακτίνες θα απορροφούνται από το αίμα και στην συνέχεια οι πληροφορίες θα συλλέγονται και θα επεξεργάζονται με σκοπό την προβολή ενός αγγειακού χάρτη πάνω στο δέρμα. Επίσης, μπορεί να γίνει και χρήση θερμικών υπερύθρων για τον έλεγχο της ροής του αίματος καθώς και την ύπαρξη πιθανής μόλυνσης.
     Αρχικά θα γίνει μια αναφορά σε πληροφορίες που αφορούν τις υπέρυθρες ακτίνες, τις υποκατηγορίες της υπέρυθρης ακτινοβολίας και τις εφαρμογές τους. Στη συνέχεια παρέχονται αδρές  γενικές πληροφορίες για το ανθρώπινο κυκλοφορικό σύστημα, την διαδικασία αιμοληψίας καθώς και τις επιπλοκές της. Τέλος αναλύονται οι ήδη υπάρχουσες μέθοδοι απεικόνισης.
Deutsche Burgen- und Schlossmodelle
Creators: name: Reuther, Hans
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2017

description: -
description: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 15, Nr. 2 (1974): Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
In vitro and in vivo immunotoxicity of PEGylated Cd-free CuInS2/ZnS quantum dots
Creators: name: Chen, Tingting
name: Li, Li
name: Lin, Xiaotan
name: Yang, Zhiwen
name: Zou, Wenyi
name: Chen, Yajing
name: Xu, Jiangyao
name: Liu, Dongmeng
name: Wang, Xiaomei
name: Lin, Guimiao
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Cell Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: The annual increase in the production and the use of engineering quantum dots (QDs) have led to concern about exposure and safety of QDs. To resolve the risk of Cd release from QDs, a series of Cd-free QDs, represented by CuInS2/ZnS QDs, has been developed in recent years. However, the toxicological profile of CuInS2/ZnS QDs has not been fully elucidated, especially, their immunotoxicity. Here, we performed a detailed in vitro cytotoxicity study on PEGylated CuInS2/ZnS QDs using the DC2.4 cell line and investigated their in vivo immunotoxicity using BALB/c mice. In vitro experiments showed that CuInS2/ZnS QDs were taken up by cells, promoted cell viability, enhanced release of tumor necrosis factor-α, and decreased the level of interleukin (IL)-6 in response to lipopolysaccharide stimulation. More than 5000 genes at the transcriptome level were observed by high-throughput RNA sequencing after CuInS2/ZnS QD exposure. In vivo study showed that CuInS2/ZnS QDs increased the levels of IL-4 on day 1 and enhanced the levels of IL-10 and IL-13 on day 28 in mice. There was no obvious difference in the number of spleen-derived lymphocytes, organic index, hematology and immune organ histology on days 1 and 28 after treatment. These findings demonstrated that PEGylated CuInS2/ZnS QDs disturbed the function of DC2.4 immune cells in vitro, but caused no obvious toxicity to immune system in vivo, suggesting that PEGylated CuInS2/ZnS QDs are biocompatible and have potential for bioapplication in the future.
Additional file 1 of Prolonged pregnancy and stillbirth among women with overweight or obesity – a population-based study in Sweden including 64,632 women
Creators: name: Akselsson, Anna
name: Rossen, Jenny
name: Storck-Lindholm, Elisabeth
name: Rådestad, Ingela
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Computational Biology

description: Additional file 1. Number of stillbirths in relation to gestational week and Body Mass Index (BMI) among 61,800 women.