cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Patrick Bouvart, Les prieurés de Fontevraud dans le diocèse de Poitiers. Conditions d’implantation, topographie monastique et évolution. Avec une préface de Claude Andrault-Schmitt et Luc Bourgeois, Rennes (Presses universitaires de Rennes) 2021
Creators: name: De Mecquenem, Claude
Publisher: name: Francia-Recensio
Year: 2022

description: Patrick Bouvart, Les prieurés de Fontevraud dans le diocèse de Poitiers. Conditions d’implantation, topographie monastique et évolution. Avec une préface de Claude Andrault-Schmitt et Luc Bourgeois, Rennes (Presses universitaires de Rennes) 2021, 220 p., 152 ill. (Archéologie et Culture), ISBN 978-2-7535-8325-2, EUR 35,00.
description: Francia-Recensio, 2022/3
Effective testing of gene-disease associations.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: We propose a method for testing any hypothesized association between a candidate allele, for which there is a specific laboratory test, and a common chronic disease. Families in which this allele is segregating are identified through index individuals who are homozygous or heterozygous for the allele. The sample consists of the subset of identified families who also have at least one member with the common disease of interest. For each independent family in this subset, select one person with the disease and determine if he or she is heterozygous for the allele. The observed proportion of heterozygotes in this sample is compared to the proportion expected on the basis of each diseased relative's null probability of being heterozygous for the allele; this null probability depends only on the relative's relationship to the index individual and the population allele frequency. We provide these null probabilities, develop appropriate inference procedures, discuss sample size requirements, and compare this method to a standard case-control design. Results using this method are unlikely to be influenced by confounders, systematic bias, or genetic heterogeneity.
Inclusion opportunities of Work 4.0? Employment realities of people with disabilities in Germany
Creators: name: Jochmaring, Jan
name: York, Jana
Publisher: name: TU Dortmund
Year: 2023
Subjects: subject: Work 4.0
subject: Inclusion
subject: People with disabilities
subject: Labour market
subject: Segregated systems
subject: Germany
subject: 360
subject: 370
subject: Soziale Inklusion
subject: Arbeitsmarkt
subject: Behinderung

description: The normative and political call for an inclusive working world as the UNCRPD explicates is not consistent with the current employment realities of people with disabilities in Germany and in the Nordic countries such as Iceland, Norway or Sweden. Only a fraction is able to find employment on the labour market, while segregated systems are expanding at the same time. We reference the ‘Work 4.0’ discourse with a particular focus on substitutability potentials and automation processes in the course of digitalization. These developments go hand in hand with the pluralization of employment constellations as well as progressive expansion of education and devaluation of qualifications. This article takes a critical look at these processes of change in the working world with regard to their effects on people with disabilities. The central contradictions between political, legal, and normative demands for employment realities to be organized inclusively as well current developments in the area of technology, employment, and knowledge are discussed.
description: Scandinavian journal of disability research;25(1)
Outflows from accretion disks formed in neutron star mergers: effect of black hole spin
Creators: name: Fernández, Rodrigo
name: Kasen, Daniel
name: Metzger, Brian D.
name: Quataert, Eliot
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The accretion disk that forms after a neutron star merger is a source of neutron-rich ejecta. The ejected material contributes to a radioactively-powered electromagnetic transient, with properties that depend sensitively on the composition of the outflow. Here we investigate how the spin of the black hole remnant influences mass ejection on the thermal and viscous timescales. We carry out two-dimensional, time-dependent hydrodynamic simulations of merger remnant accretion disks including viscous angular momentum transport and approximate neutrino self-irradiation. The gravity of the spinning black hole is included via a pseudo-Newtonian potential. We find that a disk around a spinning black hole ejects more mass, up to a factor of several, relative to the non-spinning case. The enhanced mass loss is due to energy release by accretion occurring deeper in the gravitational potential, raising the disk temperature and hence the rate of viscous heating in regions where neutrino cooling is ineffective. The mean electron fraction of the outflow increases moderately with BH spin due to a highly-irradiated (though not neutrino-driven) wind component. While the bulk of the ejecta is still very neutron-rich, thus generating heavy r-process elements, the leading edge of the wind contains a small amount of Lanthanide-free material. This component can give rise to a ~1 day blue optical `bump' in a kilonova light curve, even in the case of prompt BH formation, which may facilitate its detection.
description: Accepted by MNRAS with minor changes, added figure (#4) illustrating convergence in mass ejection
Touching points in the energy band structure of bilayer graphene superlattices
Creators: name: Pham, C. Huy
name: Nguyen, V. Lien
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Energy band structure of the bilayer graphene superlattices with zero-averaged periodic $δ$-function potentials are studied within the four-band continuum model. Using the transfer matrix method, studies are mainly focused on examining the touching points between adjacent minibands. For the zero-energy touching points the dispersion relation derived shows the Dirac-like double-cone shape with the group velocity which is periodic in the potential strength $P$ with the period of $π$ and becomes anisotropic at relatively large $P$. From the finite-energy touching points we have identified those located at zero wave-number. It was shown that for these finite-energy touching points the dispersion is direction-dependent in the sense that it is linear or parabolic in the direction parallel or perpendicular to the superlattice direction, respectively. We have also calculated the density of states and the conductivity that demonstrate a manifestation of the touching points of interest.
description: Submitted to JPCM
Boris Bove, Claude Gauvard (dir.), Notre-Dame de Paris. Une cathédrale dans la ville. Des origines à nos jours, Paris (Belin) 2022
Creators: name: Oberste, Jörg
Publisher: name: Francia-Recensio
Year: 2022

description: Boris Bove, Claude Gauvard (dir.), Notre-Dame de Paris. Une cathédrale dans la ville. Des origines à nos jours, Paris (Belin) 2022, 487 p., ISBN 978-2-410-02455-5, EUR 39,00.
description: Francia-Recensio, 2022/3
GM2-gangliosidosis B1 variant: analysis of beta-hexosaminidase alpha gene abnormalities in seven patients.
Creators: name: Brown, A
name: Tanaka, A
name: Maire, I
name: Sandhoff, K
name: Kolodny, E
name: Ohno, K
name: Suzuki, K
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: A single nucleotide transition within exon 5 of the beta-hexosaminidase alpha chain gene was identified in a Puerto Rican patient with GM2-gangliosidosis B1 variant as the mutation responsible for the unusual enzymological characteristics of this variant (G533----A; Arg178----His) (the DN-allele). A total of seven patients with enzymological characteristics of B1 variant have since been studied. They were Puerto Rican (DN), Italian, French, Spanish, two patients of mixed ethnic origin (English/Italian/Hungarian and English/French/Azores), and a Czechoslovakian. In confirmation of our earlier finding based on screening with allele-specific probes, all patients except the one from Czechoslovakia carried the same DN-allele. A new point mutation found in this patient changed the same codon affected in the DN-allele (C532----T; Arg178----Cys). An asymptomatic Japanese individual included as a control also carried one allele with the DN-mutation. Site-directed mutagenesis and expression studies in COS I cells demonstrated that either of the two point mutations abolishes the catalytic activity of the alpha subunit. The Spanish patient was homozygous for the DN-allele, but others were all compound heterozygotes. The Puerto Rican patient was a compound heterozygote with the DN-mutation in one allele and with the four-base insertion in exon 11, one of the two mutations found in the classical Ashkenazi Jewish Tay-Sachs disease, in the other allele. Abnormalities of the other allele were not identified in all other compound heterozygous patients. In these patients, the level of mRNA derived from the other allele was variable, ranging from being undetectable to being much lower than normal. This series of studies uncovered a new B1 variant mutation, confirmed our preliminary finding that the DN-allele has a surprisingly wide geographic and ethnic distribution, and pointed out the highly complex nature of the molecular genetics of this rare disorder. They also support our working hypothesis that mutations responsible for the unique enzymological characteristics of the B1 variant should be located in or near exon 5 of the gene and that this region of the enzyme protein is critical for its catalytic function.
Determining spatial disparities and similarities regarding heat exposure, green provision, and social structure of urban areas - a study on the city district level in the Ruhr area, Germany
Creators: name: Klopfer, Florian
name: Pfeiffer, Antonia
Publisher: name: TU Dortmund
Year: 2023
Subjects: subject: Urban heat island (UHI)
subject: NDVI
subject: Social vulnerability
subject: Cluster analysis
subject: Multiple burdens
subject: Climate (in-)justice
subject: Environmental (in-)justice
subject: 710

description: Heat islands and ongoing urbanization make cities places where the negative impacts of global climate change on society are becoming increasingly evident. Especially the interplay and potential multiplication of heat, low green provision, and the presence of socially deprived urban dwellers constitutes complex challenges. Emerging climate injustices and potential health issues require a powerful counter-reaction in form of adaptation action. For our study, we consider eight cities located in the densely populated and historically highly segregated Ruhr area in Western Germany, which is one of the largest metropolitan areas in Europe with a heterogeneous distribution of socio-spatial problems, economic potential, heat stress, and green infrastructures. We use land surface temperature (LST), data on green provision (normalized difference vegetation index (NDVI)), and social indicators to reveal the relationships between these indicators on the city district level (n = 275). Therefore, we first analyze the data regarding spatial autocorrelation (Moran's I) and clustering (Gi*) before calculating study area wide and city specific correlations between the three factors regarded. Finally, we conduct a cluster analysis (k-means) to disclose similar areas with or without multiple burdens. Our results show distinct disparities in heat exposure, green availability, and social status between city districts of the study area. We find strong negative correlations between LST and NDVI as well as between NDVI and social status. The relationship between LST and our social indicator remains ambiguous, affirming the necessity of further detailed studies. The cluster analysis furthermore allows for the visualization and classification of districts featuring similar characteristics regarding the researched components. We can discern in parts pronounced climate injustice in the studied cities, with a majority of people living in unfavorable environmental and socio-economic conditions. Our analysis supports governments and those responsible for urban planning in addressing climate injustice in the future.
description: Heliyon;9(6)
Action Principles for Transgression and Chern-Simons AdS Gravities
Creators: name: Mora, Pablo
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Chern-Simons gravities are theories with a lagrangian given by a Chern-Simons form constructed from a space-time gauge group. In previous investigations we showed that, for some special field configurations that are solutions of the field equations, the extension from Chern-Simons to Transgression forms as lagrangians, motivated by gauge invariance, automatically yields the boundary terms required to regularize the theory, giving finite conserved charges and black hole thermodynamics. Further work by other researchers showed that one of the action functionals considered in the above mentioned work yields a well defined action principle in the metric (zero torsion) case and for asymptotically Anti de Sitter (AdS) space-times. In the present work we consider several action functionals for Chern-Simons AdS gravity constructed from Transgression forms, and show the action principles to be well defined and the Noether charges and Euclidean action to be finite for field configurations satisfying only that the gauge field curvature (field strength) for the AdS gauge group is asymptotically finite. For that purpose we consider an asymptotic expansion of the vielbein and spin connection that may be regarded as a perturbation of an AdS space-time, but allowing a non zero torsion. Our results are of potential interest for Lovelock gravity theories, as it has been shown that the boundary terms dictated by the transgressions for Chern-Simons gravities are also suitable to regularize Lovelock theories.
description: The review sections of the present paper may have some overlap with the work of the same author arXiv:1010.5110 (which has not been published in a journal). Version 2: Subsection 6.1 clarifying action principle added, references added
title: A Review and Database of Landslide Induced Tsunamis
Creators: name:  Dohmen , Katrin
name:  Braun , Anika
name:  Fernandez-Steeger , Tomas Manuel
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: When it comes to the mining and use of local geological raw materials, a reflexive, sometimes undifferentiated social rejection arises. The ore, hydrocarbon and coal consumption have now been reduced through recycling and the use of alternative energies or have been replaced by imported products. The last open-cast lignite mine in Schöningen was closed in 2016, the last Harz ore mine in Bad Grund in 1992 and the last iron ore mining in the Salzgitter area in 1976. Petroleum is now only produced to a small extent at a few points in the northern Braunschweig region. At the same time, the consumption of resources such as sand, gravel, solid rock (especially limestone, gypsum) and water continues on a high level. The quarrying of building stone has been almost completely ceased. Some raw materials are imported to avoid the conflict over mining, to take advantage of low labor costs abroad, or simply because they are no longer available in sufficient quantities. In terms of sustainability, there is overall significant potential for improvement. In the further planning of mining sites and quarries, special protection of the groundwater reservoir is of outstanding importance. The lecture describes examples from the UNESCO Global Geopark Harz . Braunschweiger Land . Ostfalen.
Yves Blomme, Quand les cathédrales se mesuraient entre elles. L’incidence des questions hiérarchiques sur l’architecture des cathédrales en France (XIIe–XVe siècles), Pessac (Ausonius Éditions) 2022
Creators: name: Demouy, Patrick
Publisher: name: Francia-Recensio
Year: 2022

description: Yves Blomme, Quand les cathédrales se mesuraient entre elles. L’incidence des questions hiérarchiques sur l’architecture des cathédrales en France (XIIe–XVe siècles), Pessac (Ausonius Éditions) 2022, 280 p. (Scripta mediaevalia, 45), ISBN 978-2-35613-438-7, EUR 19,00.
description: Francia-Recensio, 2022/3
Claire Billen, Bruno Blondé, Marc Boone, Anne-Laure Van Bruaene (dir.), Faire société au Moyen Âge. Histoire urbaine des anciens Pays-Bas (1100–1600), Paris (Classiques Garnier) 2021
Creators: name: Paviot, Jacques
Publisher: name: Francia-Recensio
Year: 2022

description: Claire Billen, Bruno Blondé, Marc Boone, Anne-Laure Van Bruaene (dir.), Faire société au Moyen Âge. Histoire urbaine des anciens Pays-Bas (1100–1600), Paris (Classiques Garnier) 2021, 356 p. (Bibliothèque d’histoire médiévale, 25), ISBN 978-2-406-10791-0, EUR 29,00.
description: Francia-Recensio, 2022/3
DNA polymorphisms in the controlling region of the human haptoglobin genes: a molecular explanation for the haptoglobin 2-1 modified phenotype.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: A haptoglobin 2-1 modified (Hp2-1mod) phenotype results when the amount of Hp2 polypeptide synthesized in Hp2/Hp1 heterozygotes is less than that of Hp1 polypeptide. Cloned Hp2 DNA from an individual with the Hp2-1mod phenotype is here shown to have a C in place of the normal A at nucleotide position -61 in one of the interleukin-6 (IL-6) responsive elements of the haptoglobin promoter region. Direct sequencing of the haptoglobin promoter region, amplified by PCR, from DNA from unrelated American blacks showed a C at -61 in all of 10 individuals with the Hp2-1mod phenotype, in two of four with a "possible Hp2-1mod" phenotype, but in none of 15 with the Hp2-1 phenotype. Thus the -61C mutation in the Hp2-61C allele is strongly associated with the Hp2-1mod phenotype. Sequencing results also show that there are three other promoter sequences in the population studied; each can be associated with either Hp2 or Hp1. The variability seen in the Hp2-1mod phenotype, a variability which ranges from close to Hp2-1 to close to Hp1-1, can be explained, in part, by the existence of several Hp2 alleles differing in their promoters--and possibly, in part, by differences in the promoters of the accompanying Hp1 allele. A further part of the variability may be the consequence of differences in the way that the Hp2-61C and the Hp2 alleles respond to the IL-6-dependent factor during an acute-phase response.
GM2-gangliosidosis B1 variant: analysis of beta-hexosaminidase alpha gene mutations in 11 patients from a defined region in Portugal.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: The GM2-gangliosidosis B1 variant occurs at an exceptionally high frequency in the northern part of Portugal. In most patients, the disease manifests itself as a juvenile form, as opposed to the late-infantile form described for many patients from other parts of the world. We have analyzed the beta-hexosaminidase alpha gene in 11 patients, as well as in some relatives, in order to characterize the underlying abnormalities. They were screened for the two previously identified mutations responsible for the B1 variant phenotype (G533----A, also designated as the "DN allele," and C532---T) by PCR amplification of an 800-bp DNA fragment and subsequent dot-blot hybridization with allele-specific oligonucleotides. The fragment amplified from one patient was also subcloned and sequenced. Ten patients, constituting a clinically and biochemically homogeneous group, were found to be homozygous for the DN allele. The other, whose clinical profile more resembled the late-infantile phenotype often described in the literature, was a compound heterozygote carrying the DN allele and another, as yet unidentified, abnormal allele. Our results, corroborated by previously published data, suggest that homozygotes and compound heterozygotes for the DN allele may be distinguishable at the phenotypic level, depending on the nature of the abnormality in the other allele. A common ancestral origin for the DN allele can also be postulated.
A molecular deletion of distal chromosome 4p in two families with a satellited chromosome 4 lacking the Wolf-Hirschhorn syndrome phenotype.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1992

description: The authors report two families with a satellited chromosome 4 short arm (4ps). Satellites and stalks normally occur on the short arms of acrocentric chromosomes; however, the literature cites several reports of satellited nonacrocentric chromosomes, which presumably result from a translocation with an acrocentric chromosome. This is the first report of 4ps chromosomes. The families are remarkable in that both unaffected and affected individuals carry the 4ps chromosome. The phenotypes observed in affected individuals, although dissimilar, were sufficient to encourage a search for a deletion of chromosome 4p. By Southern blot analysis and fluorescence in situ hybridization, a deletion of material mapping approximately 150 kb from chromosome 4pter was discovered. This deletion is notable because it does not result in the Wolf-Hirschhorn syndrome and can result in an apparently normal phenotype. The authors speculate that homology between subterminal repeat sequences on 4p and sequences on the acrocentric short arms may explain the origin of the rearrangement and that position effect may play a role in the expression of the abnormal phenotype. 36 refs., 4 figs., 3 tabs.
Wireless Powered Communication: Opportunities and Challenges
Creators: name: Bi, Suzhi
name: Ho, Chin Keong
name: Zhang, Rui
Publisher: name: arXiv
Year: 2014
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: The performance of wireless communication is fundamentally constrained by the limited battery life of wireless devices, whose operations are frequently disrupted due to the need of manual battery replacement/recharging. The recent advance in radio frequency (RF) enabled wireless energy transfer (WET) technology provides an attractive solution named wireless powered communication (WPC), where the wireless devices are powered by dedicated wireless power transmitters to provide continuous and stable microwave energy over the air. As a key enabling technology for truly perpetual communications, WPC opens up the potential to build a network with larger throughput, higher robustness, and increased flexibility compared to its battery-powered counterpart. However, the combination of wireless energy and information transmissions also raises many new research problems and implementation issues to be addressed. In this article, we provide an overview of state-of-the-art RF-enabled WET technologies and their applications to wireless communications, with highlights on the key design challenges, solutions, and opportunities ahead.
description: Accepted for publication by IEEE Communications Magazine
title: Анализ динамики популяции волка (Canis lupus) на территории Новгородской области
Creators: name: Гаврилов, Вячеслав
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: Ежегодно в каждом регионе России комитеты охотничьих ресурсов и рыболовства собирают сведения о численности млекопитающих и птиц, отнесенных к охотничьим ресурсам, сведения о видах, местоположении, состоянии охотничьих угодий и их границах для Государственного Охотхозяйственного реестра. Хищническая
деятельности волка оказывает огромное влияние на изменение этих показателей. Ущерб от деятельности волка зависит от численности особей на территории охотничьих угодий. Специалисты указывают на важность поддержания численности особей хищника на минимально возможном уровне – это помогает исключить возможность распространения опасных для здоровья человека инфекций, таких как бешенство. А также предотвратить нападение волка на людей и животных в черте населенного пункта. Охотники организуют
ряд мероприятий, направленных на гарантированную безопасность местных жителей.
Anomalous chromomagnetic moment of quarks
Creators: name: Choudhury, Ishita Dutta
name: Lahiri, Amitabha
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We do a perturbative calculation of the anomalous chromomagnetic dipole moment of quarks at one-loop, also considering the effect of a small gauge-invariant mass of the gluon. We find partial agreement with a previous calculation, as well as a divergence. We explain these results by noting that perturbation theory is not valid at the energy scales where these calculations were done, and proceed to give the results at the $M_Z$ scale. We find significant variation, of the anomalous moment of the light quarks, as a function of gluon mass.
description: 17 pages, 12 figures; V2: References added, typos corrected in some equations, differences with existing work discussed in detail, results unchanged
Confirmation of genetic heterogeneity in limb-girdle muscular dystrophy: Linkage of an autosomal dominant form to chromosome 5q
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1992

description: Limb-girdle muscular dystrophy (LGMD) is a clinically and genetically heterogeneous group of disorders, with both recessive and dominant forms reported. Recently, a series of recessive LGMD families were linked to chromosome 15q. We report herein the results of our linkage studies in a previously reported large autosomal dominant family. The LGMD gene in this family was localized to chromosome 5q22.3-31.3 by using a series of CA(n) microsatellite repeat markers. Linkage to 15q was excluded. These findings confirm genetic heterogeneity in this clinically diverse syndrome.
"QCD-10-029_temp.pdf" of "Shape, transverse size, and charged hadron multiplicity of jets in pp collisions at 7 TeV"
Creators: name: CMS Collaboration
Publisher: name: HEPData
Year: 2015

description: Supplementary Materials tables
description: CERN-LHC. Measurements of jet characteristics from inclusive jet production in proton-proton collisions at a centre-of-mass energy of 7 TeV are presented. The data sample was collected with the CMS detector at the LHC during 2010 and corresponds to an integrated luminosity of 36 inverse picobarns. The mean charged hadron multiplicity, the differential and integral jet shape distributions, and two independent moments of the shape distributions are measured as functions of the jet transverse momentum for jets reconstructed with the anti-kT algorithm. The measured observables are corrected to the particle level. In Tables 1-125, the differential jet shape $\rho(r)$ is already corrected for the unfolding correction factor, CF, listed in the table. In Tables 1-125, three sources of systematic uncertainties for $\rho(r)$ are presented separately for completeness, and DSYS is a quadratic summation of these three systematic uncertainties.
Further localization of X-linked hydrocephalus in the chromosomal region Xq28
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1992

description: X-linked hydrocephalus (HSAS) is the most frequent genetic form of hydrocephalus. Clinical symptoms of HSAS include hydrocephalus, mental retardation, clasped thumbs, and spastic paraparesis. Recently we have assigned the HSAS gene to Xq28 by linkage analysis. In the present study we used a panel of 18 Xq27-q28 marker loci to further localize the HSAS gene in 13 HSAS families of different ethnic origins. Among the Xq27-q28 marker loci used, DXS52, DXS15, and F8C gave the highest combined lod scores, of 14.64, 6.53 and 6.33, respectively, at recombination fractions of .04, 0, and .05, respectively. Multipoint linkage analysis localizes the HSAS gene in the telomeric part of the Xq28 region, with a maximal lod score of 20.91 at 0.5 cM distal to DXS52. Several recombinations between the HSAS gene and the Xq28 markers DXS455, DXS304, DXS305, and DXS52 confirm that the HSAS locus is distal to DXS52. One crossover between HSAS and F8C suggests that HSAS gene to be proximal to F8C. Therefore, data from multipoint linkage analysis and the localization of key crossovers indicate that the HSAS gene is most likely located between DXS52 and F8C. This high-resolution genetic mapping places the HSAS locus within a region of less than 2 Mb in length, which is now amenable to positional cloning.
title: Pilotprojekt „DigiGlue“
title: Entwicklung eines prototypischen Assistenzsystems zur digitalen Reposition von Wandmalereifragmenten als Begleiter der Restaurierung am Beispiel der provinzialrömischen Funde aus dem Europäischen Kulturpark Bliesbruck-Reinheim
titleType: Subtitle
Creators: name: Kasparek, Nicole
name: Schneider, Jan
Publisher: name: HAWK Hochschule für angewandte Wissenschaft und Kunst Hildesheim/ Holzminden/Göttingen
Year: 2022
Subjects: Conservation science

description: Im Herbst 2021 wurde im Europäischen Kulturpark Bliesbruck-Reinheim (EKP) ein neuartiges System zur digitalen Wiederherstellung von ca. 12.000 römischen Wandmalereifragmenten, die bei Grabungsarbeiten im EKP gefunden wurden, in Betrieb genommen. Das System ist das Ergebnis eines Forschungs- und Entwicklungsprojekts des Landesdenkmalamtes des Saarlandes und der MFB MusterFabrik Berlin GmbH in Kooperation mit dem Fraunhofer-Institut für Produktionsanlagen und Konstruktionstechnik IPK. Ziel der gemeinsamen, unter dem Namen „DigiGlue“ durchgeführten Projektarbeit war die Entwicklung eines Assistenzsystems zur Digitalisierung, Visualisierung und digitalen Reposition der Wandmalereifragmente, mit Hilfe dessen das hoch empfindliche Kulturgut materialschonend für die Nachwelt digitalisiert und später berührungsfrei wissenschaftlich und restauratorisch weiterbearbeitet werden kann.
Lipoprotein(a) in women twins: heritability and relationship to apolipoprotein(a) phenotypes.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1992

description: Lp(a) is a unique lipoprotein consisting of an LDL-like particle and a characteristic protein, apo(a). Increased levels of Lp(a) constitute a risk factor for coronary heart disease. Variation in the size of the apo(a) protein is a phenotype controlled by the apo(a) gene on chromosome 6 and is related to Lp(a) plasma levels. Based on 169 MZ and 125 DZ adult female twin pairs, this study's purpose was to estimate the proportion of the variation in Lp(a) levels that is due to genetic influences and to determine the extent to which the apo(a) locus explains this heritability. Lp(a) levels were significantly more similar in MZ twins than in DZ twins: mean co-twin differences were 3.9 +/- 5.7 mg/dl and 16.0 +/- 19.9 mg/dl (P less than .001), respectively. Intraclass correlations were .94 in MZ twins and .32 in DZ twins, resulting in a heritability estimate of .94 (P less than .001). Heritability was then calculated using only co-twins with the same apo(a) phenotype: the heritability estimate decreased to .45 but was still highly significant (P less than .001). Therefore, on the basis of heritability analysis of women twins, Lp(a) levels are almost entirely genetically controlled. Variation at the apo(a) locus contributes to this heritability, although other genetic factors could be involved.
Power of sib-pair and sib-trio linkage analysis with assortative mating and multiple disease loci.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1992

description: Sib-pair linkage analysis has been proposed for identifying genes that predispose to common diseases. The authors have shown that the presence of assortative mating and multiple disease-susceptibility loci (genetic heterogeneity) can increase the required sample size for affected-affected sib pairs several fold over the sample size required under random mating. They propose a new test statistic based on sib trios composed of either one unaffected and two affected siblings or one affected and two unaffected siblings. The sample-size requirements under assortative mating and multiple disease loci for these sib-trio statistics are much smaller, under most conditions, than the corresponding sample sizes for sib pairs. Study designs based on data from sib trios with one or two affected members are recommended whenever assortative mating and genetic heterogeneity are suspected. 31 refs.
PRB2/1 fusion gene: a product of unequal and homologous crossing-over between proline-rich protein (PRP) genes PRB1 and PRB2.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1992

description: The PRB2/1 fusion gene is produced by homologous and unequal crossing-over between PRB1 and PRB2 genes that code for basic salivary proline-rich proteins (PRPs). To determine the molecular basis for the PRB2/1 fusion gene, the DNA sequence was determined for the PRB2/1 gene and was compared with those of the PRB1 and PRB2 genes. From these comparisons, the crossing-over is postulated to occur in a 743-bp region of identity, with only 1-bp mismatch between the PRB1 and PRB2 genes, in the third intron outside the coding region of the two genes. This region of virtual complete identity is the largest found between any of the six closely linked PRB genes and may facilitate recombination. Since the coding region of PRB1 is completely absent from the PRB2/1 gene, salivas from two white PRB2/1 homozygotes were studied to determine which polymorphic PRPs were missing from the salivas. Polymorphic PRPs Pe, PmF, PmS, and Ps were found to be missing from the salivas. However, a white individual lacking the same salivary PRPs is a PRB2/1 heterozygote with one PRB1 allele. The explanation for the missing salivary proteins in this individual is unknown. The PRB2/1 gene is relatively frequent in several populations of unrelated individuals, including American blacks (n = 41), American Utah whites (n = 76), and mainland Chinese (n = 131), with gene frequencies of .22, .06, and .09, respectively. Evidence for the occurrence of PRB1/2 heterozygotes is also presented.
'Einselection' of Pointer Observables: The New H-Theorem?
Creators: name: Kastner, Ruth E.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: History and Philosophy of Physics (physics.hist-ph)
subject: FOS: Physical sciences

description: In attempting to derive irreversible macroscopic thermodynamics from reversible microscopic dynamics, Boltzmann inadvertently smuggled in a premise that assumed the very irreversibility he was trying to prove: 'molecular chaos.' The program of 'Einselection' (environmentally induced superselection) within Everettian approaches faces a similar 'Loschmidt's Paradox': the universe, according to the Everettian picture, is a closed system obeying only unitary dynamics, and it therefore contains no distinguishable environmental subsystems with the necessary phase randomness to effect einselection of a pointer observable. The theoretically unjustified assumption of distinguishable environmental subsystems is the hidden premise that makes the derivation of einselection circular. In effect, it presupposes the 'emergent' structures from the beginning. Thus the problem of basis ambiguity remains unsolved in Everettian interpretations.
description: To appear in in Studies in History and Philosophy of Modern Physics; a few typos corrected
Anisotropy of incommensurate magnetic excitations in slightly overdoped Ba$_{0.5}$K$_{0.5}$Fe$_2$As$_2$ probed by polarized inelastic neutron scattering experiments
Creators: name: Qureshi, N.
name: Lee, C. H.
name: Kihou, K.
name: Schmalzl, K.
name: Steffens, P.
name: Braden, M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Polarized neutron scattering experiments on the slightly overdoped superconductor Ba$_{0.5}$K$_{0.5}$Fe$_2$As$_2$ reveal broad magnetic resonance scattering peaking at approximately 15 meV. In spite of doping far beyond the suppression of magnetic order, this compound exhibits dispersive and anisotropic magnetic excitations. At energies below the resonance maximum, magnetic correlations polarized parallel to the layers but perpendicular to the propagation vector are reduced by a factor two compared to those in the two orthogonal directions; in contrast correlations at the peak maximum are isotropic.
description: 5 pages, 5 figures
Ist die Wirksamkeit von alkoholischen Händedesinfektionsmitteln bei Enterokokken wirklich in Gefahr?
Creators: name: Schwebke, Ingeborg
name: Arvand, Mardjan
name: Werner, Guido
name: Konrat, Katharina
name: Brunke, Melanie
Publisher: name: Robert Koch-Institut
Year: 2018
Subjects: subject: 610 Medizin und Gesundheit

description: Im August 2018 sorgte eine in Science Translational Medicine publizierte Studie von Pidot et al. für ein erhebliches Medienecho. Die Autoren untersuchten die Alkoholtoleranz bei Enterokokken, insbesondere bei den klinisch sehr relevanten Vancomycin-resistenten Enterokokken (VRE). Begründen die dargestellten Ergebnisse tatsächlich eine reale Gefahr für die Wirksamkeit von Hände­desinfektions­mitteln? Diese Frage wird im Epidemiologischen Bulletin 38/2018 diskutiert.
A base substitution in the promoter associated with the human haptoglobin 2-1 modified phenotype decreases transcriptional activity and responsiveness to interleukin-6 in human hepatoma cells.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: An A-to-C base substitution at nucleotide position -61 in the promoter region of the human haptoglobin gene (Hp) has been shown to be strongly associated with the haptoglobin 2-1 modified (Hp2-1mod) phenotype. In order to investigate whether this base substitution is the cause of reduced expression of the Hp2 allele relative to the Hp1 allele in individuals with the Hp2-1mod phenotype, we used the chloramphenicol acetyl transferase (CAT) expression system to evaluate promoter function. In HepG2 cells, which normally express their endogenous haptoglobin genes, CAT plasmid constructs with the -61C base change in the promoter had about 10-fold-lower transcriptional activity after transfection than did the Hp control construct. The -61C substitution also rendered the construct unresponsive to treatment by interleukin-6 after transfection into Hep3B2 cells, which normally do not express haptoglobin but do so in response to stimulation by acute-phase reactants. In addition, two base substitutions, T to A and A to G, at positions -104 and -55G, respectively, in the promoter region of the Hp1 allele, are also associated with the Hp2-1mod phenotype. CAT constructs with both substitutions (-104A-55G) and with one substitution (-55G) showed activity similar to that in the Hp control when transfected into both HepG2 and Hep3B2 cells, although interleukin-6 induction was less than with the Hp control construct. These results further support the hypothesis that the Hp2-1mod phenotype results, in part, from the -61C mutation in the promoter region of the Hp2 gene.
title: Расширение ассортимента желейных кондитерских изделий
Creators: name: Галафеева, Анастасия
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: Сейчас в мире очень популярно движение за здоровый образ жизни (ЗОЖ). Люди стали больше заботиться о себе, о своем здоровье, вследствие чего они стали больше следить за тем, что они употребляют в пищу. К сожалению, очень многие продукты на прилавках магазинов содержат вредные консерванты, которые могут навредить нам. Эта проблема не обошла стороной и желе. Некоторые производители ради того, чтобы
улучшить органолептические показатели своей продукции, при этом не тратя большие деньги на сырье, вносят в рецептуру пищевые добавки, и далеко не все из них безобидны. В малом количестве сильного вреда организму они не нанесут, но это может произойти, если продукт употребляется в пищу регулярно. В связи с этим предложена разработка желе без добавления белого сахара. Рецептура включает в себя воду, ягоды, и загуститель.
The Continuum of Discrete Trajectories in Eternal Inflation
Creators: name: Vanchurin, Vitaly
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We discuss eternal inflation in context of classical probability spaces defined by a triplet: sample space, $σ$-algebra and probability measure. We show that the measure problem is caused by the countable additivity axiom applied to the maximal $σ$-algebra of countably infinite sample spaces. This is a serious problem if the bulk space-time is treated as a sample space which is thought to be effectively countably infinite due to local quantum uncertainties. However, in semiclassical description of eternal inflation the physical space expands exponentially which makes the sample space of infinite trajectories uncountable and the (future) boundary space effectively continuous. Then the measure problem can be solved by defining a probability measure on the continuum of trajectories or holographically on the future boundary. We argue that the probability measure which is invariant under the symmetries of the tree-like structure of eternal inflation can be generated from the Lebesgue measure on unit interval. According to Vitali theorem the Lebesgue measure leaves some sets without a measure which means that there are certain probabilistic questions in eternal inflation that cannot be answered.
description: 12 pages
Hereditary overexpression of adenosine deaminase in erythrocytes: evidence for a cis-acting mutation.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: Overexpression of adenosine deaminase (ADA) in red blood cells is inherited as an autosomal dominant trait and causes hemolytic anemia. The increased ADA activity in erythrocytes is due to an increase in steady-state levels of ADA mRNA of normal sequence. Increased ADA mRNA may be due to a cis-acting mutation which results in increased transcription or a loss of down-regulation during erythroid differentiation. Alternatively, it is possible that the mutation is in a trans-acting factor which interacts with normal ADA transcriptional elements to cause overexpression in red blood cells. To discriminate between a cis-acting and a trans-acting mutation, the authors took advantage of a highly polymorphic TAAA repeat located at the tail end of an Alu repeat approximately 1.1 kb upstream of the ADA gene. Using PCR to amplify this region, the authors identified five different alleles in 19 members of the family. All 11 affected individuals had an ADA allele with 12 TAAA repeats, whereas none of the 8 normal individuals did. The authors conclude that this disorder results from a cis-acting mutation in the vicinity of the ADA gene. 24 refs., 3 figs.
On the Numerical Treatment and Dependence of Thermohaline Mixing in Red Giants
Creators: name: Lattanzio, John
name: Siess, Lionel
name: Church, Ross
name: Angelou, George
name: Stancliffe, Richard
name: Doherty, Carolyn
name: Stephen, Thomas
name: Campbell, Simon
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: In recent years much interest has been shown in the process of thermohaline mixing in red giants. In low and intermediate mass stars this mechanism first activates at the position of the bump in the luminosity function, and has been identified as a likely candidate for driving the slow mixing inferred to occur in these stars. One particularly important consequence of this process, which is driven by a molecular weight inversion, is the destruction of lithium. We show that the degree of lithium destruction, or in some cases production, is extremely sensitive to the numerical details of the stellar models. Within the standard 1D diffusion approximation to thermohaline mixing, we find that dfferent evolution codes, with their default numerical schemes, can produce lithium abundances that differ from one another by many orders of magnitude. This disagreement is worse for faster mixing. We perform experiments with four independent stellar evolution codes, and derive conditions for the spatial and temporal resolution required for a converged numerical solution. The results are extremely sensitive to the timesteps used. We find that predicted lithium abundances published in the literature until now should be treated with caution.
description: 19 pages, 18 figures, accepted for publication by MNRAS; revised version has corrected Fig 17
title: William James. Alcuni problemi di psicologia
Creators: name: Bella, Michela
Publisher: name: Roma TrE-Press
Year: 2022

description: Il crescente interesse per il filosofo e psicologo americano William James (1842-1910) è al centro di numerosi dibattiti che attraversano diversi ambiti disciplinari. Questo fascicolo propone la traduzione italiana di due articoli psicologici dell’autore, meno noti al pubblico italiano, accompagnati da un saggio introduttivo e da un breve glossario. L’obiettivo è presentare il punto di vista di James su alcuni dibattiti di fine Ottocento riguardanti le vexatae quaestiones del rapporto mente-corpo e della percezione spaziale. Tali dibattiti portano in primo piano le inevitabili e problematiche interconnessioni metodologiche, epistemologiche e metafisiche tra gli sviluppi della psicologia sperimentale e la filosofia e già introducono la convinzione filosofica di James che la costruzione di una rinnovata concezione dell’empirismo possa far dialogare le nuove scoperte scientifiche con l’esigenza filosofica di comprendere e analizzare le implicazioni delle vecchie e nuove metodologie applicate.