cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Cholesterol transfer by NPC2 protein and cyclodextrins in Niemann Pick type C disease
Creators: name: McCauliff, Leslie Ann
Publisher: name: No Publisher Supplied
Year: 2014

description: The cholesterol storage disorder Niemann-Pick type C (NPC) disease is caused by mutations in either of two lysosomal proteins, NPC1 or NPC2.  NPC2 is a 16kDa soluble protein that binds cholesterol.  Previous work showed that NPC2 rapidly transports cholesterol to/from vesicles via direct interaction with membranes.  In the present site-directed mutagenesis studies, results suggest that the NPC2 surface may have two membrane interacting domains necessary for its cholesterol transport properties.  Using a light scattering assay, it was found that NPC2 promotes vesicle-vesicle interactions, supporting the hypothesis for two membrane interaction domains.  Results from kinetic sterol transfer assays also indicate that lysobisphosphatidic acid (LBPA), found uniquely in endo/lysosomes, dramatically enhances cholesterol transfer rates by wt NPC2.  Sterol transfer and protein-lipid binding studies of NPC2 mutant proteins indicate that NPC2 directly interacts with LBPA, and suggest that the ‘hydrophobic knob’ region of NPC2 is the LBPA-sensitive domain.      Cyclodextrins (CD) have been shown to reduce symptoms and extend lifespan in murine models of NPC disease.  In the present studies the mechanism of sterol transport by CD was investigated.  Results indicate that CD directly interacts with membranes to transfer sterol, similar to NPC2.  Absolute transfer rates were slower for CD than NPC2, however, and unlike NPC2, LBPA did not enhance transfer rates by CD.  CD also promoted vesicle-vesicle interactions, similar to NPC2.  Thus, the efficacy observed in NPC disease models is likely the result of CD enhancement of cholesterol transport between membranes, with rapid sterol transfer occurring during CD−membrane interactions.  Unfortunately, continuous administration of CD is required for therapeutic benefit, due to rapid renal elimination.  We tested a library of novel CD polyrotaxanes (PRTx), which should have increased circulation time in plasma, in npc2-/- fibroblasts.  These polymers have environmentally sensitive endcaps, theoretically allowing for controlled release of CD monomers at high concentrations within the endo/lysosomal compartment.  Indeed, the PRTx compounds rapidly reduced accumulated intracellular cholesterol in npc2-/- fibroblasts, suggesting that they may prove useful in therapeutic application to NPC disease.
Chorthippus (Chorthippus) dorsatus
Creators: name: Sultana, Riffat
name: Song, Hojun
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Acrididae
Chorthippus
Chorthippus dorsatus

description: 3. Chorthippus (Chorthippus) dorsatus (Zetterstedt, 1821)
This rare species only restricted to Azad Jammu & Kashmir and notably absent from the other regions based on its distribution across Pakistan.
description: Published as part of Sultana, Riffat & Song, Hojun, 2024, Annotated catalogue of Pakistani Acrididae (Orthoptera: Caelifera: Acridoidea), pp. 1-47 in Zootaxa 5486 (1) on page 34, DOI: 10.11646/zootaxa.5486.1.1, http://zenodo.org/record/13209743
MOESM1 of Phage typing or CRISPR typing for epidemiological surveillance of Salmonella Typhimurium?
Creators: name: Mohammed, Manal
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Table S1. CRISPR and CRISPOL types of outbreak and non-outbreak associated DT8 strains of S. Typhimurium. Identical CRISPR and CRISPOL types were detected among outbreak and non-outbreak strains.
Buettneriodrilus sexpunctatus Zicsi & Csuzdi 1986
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Opisthopora
Eudrilidae
Buettneriodrilus
Buettneriodrilus sexpunctatus

description: Buettneriodrilus sexpunctatus Zicsi & Csuzdi, 1986
Buettneriodrilus sexpunctatus Zicsi & Csuzdi, 1986b Acta Zool. Hung. 32: 396.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 17, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Achiridae Rafinesque 1815
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Pleuronectiformes
Achiridae

description: Family Achiridae Rafinesque 1815 (Fig. 4A). American Soles; Lenguados Redondos, Suelas Americanas, Lenguados Derechos
Description: Body strongly compressed, flattened, rounded in shape; up to 35 cm; snout rounded; mouth small, oblique, a little under snout; lips fleshy, often fringed; eyes on the right side, close together, small to minute; preoperculum edge covered with skin but visible as a superficial groove; origin of the dorsal fin well before the eye, with the frontal rays in a skin envelope and hard to see; pectoral present or absent, better developed on the eye side, rudimentary or absent on the blind side; both pelvic fins present, right pelvic fin joined to the anal fin; caudal fin not connected to the dorsal and anal fins (Robertson & Allen 2015, Nelson et al. 2016). Distribution: Marine (often brackish) and freshwater; tropical and subtropical waters of America (Nelson et al. 2016). Two genera and four species in Nicaraguan freshwaters.
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 43, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Buettneriodrilus sulcatus Zicsi & Csuzdi 1986
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Opisthopora
Eudrilidae
Buettneriodrilus
Buettneriodrilus sulcatus

description: Buettneriodrilus sulcatus Zicsi & Csuzdi, 1986
Buettneriodrilus sulcatus Zicsi & Csuzdi, 1986b Acta Zool. Hung. 32: 391.
Buettneriodrilus sulcatus: Zicsi 1997b Rev. suisse Zool. 104: 182.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 17, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Pternoscirta cinctifemur
Creators: name: Sultana, Riffat
name: Song, Hojun
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Acrididae
Pternoscirta
Pternoscirta cinctifemur

description: 1. Pternoscirta cinctifemur (Walker, 1859)
This species is only restricted to India and Nepal (Cigliano et al. 2024). We have reported four individuals from Azad Jammu & Kashmir, which suggests its limited distribution underscores the need for conservation efforts.
description: Published as part of Sultana, Riffat & Song, Hojun, 2024, Annotated catalogue of Pakistani Acrididae (Orthoptera: Caelifera: Acridoidea), pp. 1-47 in Zootaxa 5486 (1) on page 34, DOI: 10.11646/zootaxa.5486.1.1, http://zenodo.org/record/13209743
Chuniodrilus congoensis Zicsi 1997
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Opisthopora
Eudrilidae
Chuniodrilus
Chuniodrilus congoensis

description: Chuniodrilus congoensis Zicsi, 1997
Chuniodrilus congoensis Zicsi, 1997b Rev. suisse Zool. 104 (1): 180.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 17, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Achirus lineatus
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Pleuronectiformes
Achiridae
Achirus
Achirus lineatus

description: Achirus lineatus (Linnaeus 1758). Lined Sole; Suela Pintada
Vouchers: UCR 0363-001 (10). Distribution: Western Atlantic Ocean; from southern Carolina, USA, to northern Argentina; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) Pr, KP and Es (Atlantic); 0–6 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2019), population trend unknown.
Literature: Fowler (1923: 32; listed, including information on distribution), Villa (1982: 237; detailed description, including illustrations and an identification key, and information on distribution and ecology), Robertson & Van Tassell (2019: 4329; detailed description, including illustrations, and information on distribution, with a map, and ecology) and Angulo (2021: 43; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 43, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Eminoscolex baloghi Zicsi & Csuzdi 1986
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Opisthopora
Eudrilidae
Eminoscolex
Eminoscolex baloghi

description: Eminoscolex baloghi Zicsi & Csuzdi, 1986
Eminoscolex baloghi Zicsi & Csuzdi, 1986a Acta Zool. Hung. 32: 186.
Eminoscolex balogi: Zicsi 1997b Rev. suisse Zool. 104: 181.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 17, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Ochrilidia beybienkoi Cejchan 1969
Creators: name: Sultana, Riffat
name: Song, Hojun
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Acrididae
Ochrilidia
Ochrilidia beybienkoi

description: 3. Ochrilidia beybienkoi Cejchan, 1969
This arid mountainous species has been reported in Panjgur, Kech, Balochistan. While its known range is primarily restricted to Afghanistan, the collection of this species in Balochistan reflects its sporadic nature (Wagan & Sultana 2013).
description: Published as part of Sultana, Riffat & Song, Hojun, 2024, Annotated catalogue of Pakistani Acrididae (Orthoptera: Caelifera: Acridoidea), pp. 1-47 in Zootaxa 5486 (1) on page 34, DOI: 10.11646/zootaxa.5486.1.1, http://zenodo.org/record/13209743
Pachyacris vinosa
Creators: name: Sultana, Riffat
name: Song, Hojun
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Acrididae
Pachyacris
Pachyacris vinosa

description: 4. Pachyacris vinosa (Walker, 1870)
This species is widespread in China and surrounding areas, including Vietnam, Nagaland, Bangladesh, Nepal, and Himachal Pradesh. During this expedition, a single individual was captured from Azad Jammu & Kashmir. However, this species is limited to the Maharashtra western peninsular region of India (Cigliano et al. 2024. Therefore, conservation efforts are essential to ensure its protection.
description: Published as part of Sultana, Riffat & Song, Hojun, 2024, Annotated catalogue of Pakistani Acrididae (Orthoptera: Caelifera: Acridoidea), pp. 1-47 in Zootaxa 5486 (1) on page 35, DOI: 10.11646/zootaxa.5486.1.1, http://zenodo.org/record/13209743
Eminoscolex franzi Zicsi & Csuzdi 1986
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Opisthopora
Eudrilidae
Eminoscolex
Eminoscolex franzi

description: Eminoscolex franzi Zicsi & Csuzdi, 1986
Eminoscolex steindachneri franzi Zicsi & Csuzdi, 1986a Acta Zool. Hung. 32: 198.
Eminoscolex steindachneri franzi Zicsi & Csuzdi, 1986b Acta Zool. Hung. 32: 389.
Eminoscolex franzi: Csuzdi et al. 2015 Afr. Invert. 56: 27.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 17, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Choroedocus pallens Uvarov 1933
Creators: name: Sultana, Riffat
name: Song, Hojun
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Acrididae
Choroedocus
Choroedocus pallens

description: 5. Choroedocus pallens Uvarov, 1933
This Palearctic species was reported by Uvarov (1933) from Mach Bolan, Balochistan. Although we conducted several expeditions, we were unable to collect any individuals.
description: Published as part of Sultana, Riffat & Song, Hojun, 2024, Annotated catalogue of Pakistani Acrididae (Orthoptera: Caelifera: Acridoidea), pp. 1-47 in Zootaxa 5486 (1) on page 35, DOI: 10.11646/zootaxa.5486.1.1, http://zenodo.org/record/13209743
Eminoscolex pauliani Zicsi & Csuzdi 1986
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Opisthopora
Eudrilidae
Eminoscolex
Eminoscolex pauliani

description: Eminoscolex pauliani Zicsi & Csuzdi, 1986
Eminoscolex pauliani Zicsi & Csuzdi, 1986b Acta Zool. Hung. 32: 387.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 17, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Achirus mazatlanus
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Pleuronectiformes
Achiridae
Achirus
Achirus mazatlanus

description: Achirus mazatlanus (Steindachner 1869). Hairy Sole, Mazatlan Sole, Pacific Lined Sole; Suela Arepita, Lenguado-Redondo Listado
Vouchers: UCR 0483-003 (2); other collections: KUI 22694 (1), UF 106913 (1) and 106945 (1). Distribution: Eastern Pacific Ocean; from southern Baja California Sur, Mexico, to northern Peru; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) PN and Ni (Pacific); 0–10 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2019), population trend unknown. Literature: Villa (1982: 237; detailed description, including illustrations and an identification key, and information on distribution and ecology), Robertson & Allen (2015: 2358; detailed description, including illustrations, and information on distribution, with a map, and ecology) and Angulo (2021: 43; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 43, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Late Quaternary sedimentary geology of North Turkwel, Turkana County, Kenya
Creators: name: Martin, Rosa Linda
Publisher: name: No Publisher Supplied
Year: 2014

description: Sedimentary strata exposed in the region of North Turkwel, in the Lake Turkana Basin of northern Kenya, are described here in detail for the first time.  Research undertaken here has 1) investigated the spatial distribution of facies through geologic mapping and sedimentary analysis, 2) documented a sequence of events through relative dating and radiocarbon age analysis of ostracods from two sections and 3) made comparisons between facies sequences in the study area and previously published lake level curves for the last 13,000 cal. yr BP in the Turkana Basin.  Investigated strata from North Turkwel are comprised of deltaic and lacustrine deposits of the Galana Boi Formation that displays distinct characteristics when compared to previous research and Galana Boi deposits from the northeastern lake margin. These differences are attributed to each region’s fluvial system (Turkwel vs. Omo River), terrane of the drainage basin (metamorphic vs. volcanic), and wind patterns that affect lake currents and the distribution of sediment (high vs. low energy shoreline and wave vs. fluvial-dominated deltas). The majority of investigated deposits in this study formed during the latest Pleistocene to Holocene pluvials of the African Humid Period (AHP) in which the Turkana Basin experienced two lake highstand phases from 11,500 to 5,300 cal. yr BP.  Facies analyses show grain size and sedimentary structure characteristics that correlate with a particular deltaic zone or lacustrine setting and are shaped by processes unique to this region.  In North Turkwel, lacustrine and deltaic deposits have so far been located up to &0 meters above the present (2011) water surface of Lake Turkana and indicate transgression and regression episodes across the basin. In summary, this study reconstructs the paleoenvironment and paleogeography of North Turkwel during a humid climate of the Late Quaternary and evaluates the terrane, processes, and depositional patterns across a basin with vastly fluctuating lake levels.
Sincere backhanded compliments
Creators: name: Malyk, Maria V.
Publisher: name: No Publisher Supplied
Year: 2014

description: In polite cultures, praise serves as valuable social currency, yet, some compliments can be counterproductive. My dissertation is dedicated to identifying and analyzing mixed messages in communication called “cryptosemes”, with the central focus on popular compliments erected on a problematic premise. A cryptosemic compliment is a message in communication that is routinely exchanged on the virtue of its good intentions, while closer, mindful scrutiny reveals other obscured dimensions of meaning that subvert the implied praise but go unperceived or ignored by all parties involved. Cryptosemic compliments are rooted in deeply internalized, reified notions of what is normal, natural and true and serve as a window into cultural stereotypes and double-standards operating under the veneer of praise. The problematic dimensions of meaning within a cryptosemic compliment lie not in the verbalized content but in the unspoken, “mythologized”, mindlessly taken-for-granted presuppositions underlying the words. Drawing on Goffman’s concept of “face-work” as well as Brown and Levinson’s framework on politeness, I argue that cryptosemic praise is a “face-saving” discourse strategy automatically deployed in reaction to “face threatening social themes” that arise in conversations that either touch upon “controversial” topics or involve socio-culturally diverse participants.   Referencing data from my empirical study, I further probe the hierarchical (vertical and horizontal) relationships and the power dynamics involved in giving, receiving and making sense of cryptosemic praise. Finally, a look at the cognitive structural mechanics of cryptosemes helps shine light onto the neuro-cognitive complexities involved in public self-expression and communication. Relying on Wilson’s theory of the “adaptive unconscious”, I suggest that there exists a cognitive dissonance on the level of cultural value systems: that popular cryptosemic compliments are a manifestation of an intra-personal conflict between “old” and “new” cultural posits as well as a “communication bypass” between the conscious and unconscious information processing / meaning-making faculties of the mind. An interdisciplinary analysis of cryptosemic praise exposes the subtle but entrenched language of inequality as well as the collective silences surrounding the uncomfortable social topics buried within these seemingly innocuous, socially sanctioned expressions of courtesy.
Spatial training in the Morris water maze induces differential changes in interleukin-1 beta(IL-1β) expression in hippocampal and extra-hippocampal tissue
Creators: name: Mallimo, Elyse M
Publisher: name: No Publisher Supplied
Year: 2014

description: It is now well accepted that the brain and the immune system are intimately linked and that cytokines, small proteins secreted by cells of the immune system, exert diverse effects on CNS function. Of particular importance in this regard is the proinflammatory cytokine interleukin-1 beta (IL-1β) which is critically involved in peripheral and central inflammatory responses. Although early research surrounding the biological effects of IL-1β has focused on its detrimental role in cognitive function, emerging data strongly suggest that physiologically-low levels of IL-1β are required for hippocampal-dependent learning and long-term memory formation. In light of these observations, the present series of experiments were conducted in order to better characterize the spatio-temporal expression of IL-1β during spatial learning in the Morris water maze (MWM).    To that end, IL-1β (protein) expression was measured in the dorsal hippocampus at different time points and after one or three sessions of spatial training in the MWM (experiment 1). Moreover, because spatial navigation may depend on a distributed network of structures besides the hippocampus, IL-1β expression was also measured in the prefrontal cortex (PFC). Results from experiment 1 are suggestive of a coordinated modulation of IL-1β between the dorsal hippocampus and PFC that persists for at least the first three days of spatial training. In light of these observations and because microglial cells represent a primary source of IL-1β in the CNS, experiment 2 was conducted in order to determine whether learning induced changes in microglial activation. Results from experiment 2 reveal a training-specific downregulation of microglial cell activity in the PFC and are in agreement with a physiological role for microglia in the normal healthy brain. Finally, a third experiment was conducted in order to determine whether massed spatial training induces the expression of IL-1β, and other components of the IL-1 system.
Eminoscolex seidlae Zicsi & Csuzdi 1986
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Opisthopora
Eudrilidae
Eminoscolex
Eminoscolex seidlae

description: Eminoscolex seidlae Zicsi & Csuzdi, 1986
Eminoscolex seidlae Zicsi & Csuzdi, 1986a Acta Zool. Hung. 32: 193.
Eminoscolex seidlae: Zicsi 1997b Rev. suisse Zool. 104: 181.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 17, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Paleoenvironmental changes associated with the Paleocene-­Eocene thermal maximum, Millville (ODP Leg 1&4AX), New Jersey coastal plain
Creators: name: Makarova, Maria
Publisher: name: No Publisher Supplied
Year: 2014

description: The Paleocene-Eocene Thermal Maximum (PETM) was an abrupt warming of about 5°C that lasted ~1&0-220 kyr.  The PETM is recognized by the Carbon Isotope Excursion (CIE), represented by a ~2.5-4 ‰ decrease in planktonic foraminiferal δ13C values in open ocean cores (Kennett and Stott, 1991; Zachos et al., 2003).  The New Jersey coastal plain contains thick (~15 m) sections recording the PETM.  Kopp et al. (2009) proposed an enhanced hydrologic cycle to explain the widespread clay deposition on the mid-Atlantic continental shelf during the PETM, suggesting an Appalachian Amazon analog.  An increased flux of fresh water to the shelf would have lowered salinities substantially.  I tested this hypothesis by measuring changes in salinity in the PETM section in the Millville, New Jersey core (ODP Leg 1&4AX).  I used two paleothermometers to constrain temperature changes associated with planktonic foraminiferal δ18O variations, with the residual attributed to salinity-induced δ18Owater changes.  Using the TEXH86 calibration of Kim et al. (2010), I compute a 5.5°C warming across the CIE at Millville from 30°C to 35.5°C; using the TEXL86 calibration, I compute a &°C warming, but cooler temperatures (23-30°C).  Mg/Ca ratio of planktonic foraminifera shows less warming of ~5°C from 29.5°C to 34.3°C.  TEX86 shows a possible precursor warming at Wilson Lake and Bass River, NJ (Zachos et al., 2006; Sluijs et al., 200&).  I compare TEX86 at Wilson Lake Hole A, Bass River, and Millville and conclude that the precursor warming may be spurious because it only occurs in TEXH86 and not TEXL86.  Intermediate dwelling (Subbotina) planktonic foraminifera show a large decrease in δ18O values (~2.26 ‰) across the CIE.  Use of the TEXH86 calibration and Mg/Ca ratio calibration (Anand et al., 2003) requires unrealistic salinities exceeding 44 psu.  The TEXL86 calibration requires realistic salinity estimates and a ~4 psu salinity decrease associated with the CIE.  This suggests a freshening of surface and intermediate waters during the CIE due to an enhanced hydrological cycle as proposed by Kopp et al. (2009).  I attribute changes in surface to deep dwelling planktonic δ18O values to a breakdown of the thermocline caused by increased storm intensity during the PETM.
Lithostratigraphy and clay mineralogy of Paleocene-Eocene thermal maximum sediments at Wilson Lake, NJ
Creators: name: Lombardi, Christopher J.
Publisher: name: No Publisher Supplied
Year: 2014

description: The Marlboro Formation is an almost exclusively fine-grained and highly kaolinitic unit deposited during the Paleocene-Eocene Thermal Maximum (ca. 56 Ma).  It presents a unique opportunity to study an exceptionally thick carbon isotope excursion and continental shelf sedimentation during a geologically brief episode of global warming.  Moreover, the dominantly clayey-silt lithology is traceable over hundreds of kilometers within the Mid-Atlantic Coastal Plain physiographic province and has been drilled at numerous locations.  Here, I report lithologic changes within the Marlboro Formation from a corehole at Wilson Lake, NJ to ascertain the environment of deposition and its implications for the isotopic record.  Using differences in bedding character, quantified clay mineral identification, fine and coarse fraction grain size analysis, and core scanning x-ray fluorescence of major elements, I show that subtle facies changes are consistent with a shoaling depocenter that is aggrading above a modern shelf clinoform rollover.    Previous work has identified the continental shelf adjacent to the Amazon River as a possible analog for the sedimentary environment of the Marlboro Formation.  Sedimentary processes and the morphology of the Amazon shelf may be similar to those that produced the Marlboro Formation.  Enhanced physical weathering and continental runoff are inferred from the clay mineralogic changes in the PETM section, and are consistent with the PETM climate.  Furthermore, the Amazon experiences high rates of deposition in excess of those hypothesized for the New Jersey shelf.  Particular clay minerals are also used to demonstrate increased sedimentation rates by measuring the extent of alteration caused by seawater.  Rhythmic beds that have previously been interpreted as annual layers based on the periodic cycles in stable isotopes are here interpreted as sediment gravity flow deposits caused by wave-enhanced mud suspensions (fluid mud) like those documented on mud-rich shelves worldwide.  The depositional model put forward here supports the extremely rapid onset to the carbon isotope excursion that has been proposed in the shallow marine environment.
Trinectes fonsecensis
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Pleuronectiformes
Achiridae
Trinectes
Trinectes fonsecensis

description: Trinectes fonsecensis (Günther 1862) (Fig. 8D). Spotted Fin Sole; Suela Rayada, Lenguado-Redondo Rayado
Vouchers: UCR 0187-003 (20); other collections: UF 106609 (1). Distribution: Eastern Pacific Ocean; from the Gulf of California, Mexico, to northern Peru; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) PN (Pacific); 0–10 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2019), population trend unknown. Literature: Villa (1982: 239; detailed description, including illustrations and an identification key, and information on distribution and ecology), Bussing (1998: 433; brief description, including illustrations and an identification key, and information on distribution, with a map, and ecology), Robertson & Allen (2015: 2363; detailed description, including illustrations, and information on distribution, with a map, and ecology) and Angulo (2021: 44; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 43, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Dociostaurus (Dociostaurus) maroccanus
Creators: name: Sultana, Riffat
name: Song, Hojun
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Acrididae
Dociostaurus
Dociostaurus maroccanus

description: 6. Dociostaurus (Dociostaurus) maroccanus (Thunberg, 1815)
The Moroccan locust is widespread across western Europe and the temperate zones surrounding some parts of the Palearctic regions. However, it is rarely found in Chaman, Quetta, and Zhob districts of Balochistan.
description: Published as part of Sultana, Riffat & Song, Hojun, 2024, Annotated catalogue of Pakistani Acrididae (Orthoptera: Caelifera: Acridoidea), pp. 1-47 in Zootaxa 5486 (1) on page 35, DOI: 10.11646/zootaxa.5486.1.1, http://zenodo.org/record/13209743
Eminoscolex thibaudi Zicsi & Csuzdi 1986
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Opisthopora
Eudrilidae
Eminoscolex
Eminoscolex thibaudi

description: Eminoscolex thibaudi Zicsi & Csuzdi, 1986
Eminoscolex thibaudi Zicsi & Csuzdi, 1986a Acta Zool. Hung. 32: 196.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 17, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Statistical applications to cardiovascular disease research
Creators: name: Liu, Kezhen
Publisher: name: No Publisher Supplied
Year: 2014

description: Cardiovascular disease (CVD) is the most frequent cause of deaths worldwide [1]. Scien-tists have done and are stilling doing a high volume of research on this area, hoping to help people who are already suffering from the disease and also to prevent those at high risk of getting CVD. Statistical applications play a very important role in most of these research activities and a better utilization of the right statistical methodology for a specif-ic study would definitely make the research outcomes more reliable and eventually being beneficial to the human kind. This dissertation studies several scenarios in cardiovascular disease research where traditional statistical methods may not be applicable. And we pro-posed corresponding practical solutions or modifications to existing methods to better fit the problems case by case.     In the first part, we are focusing on using the gain in life expectancy to assess the treat-ment effect of an antihypertensive therapy for stroke. We first propose a framework for estimating this quantity by calculating the area between estimated survival curves given by two comparative treatments. And then, in order to better assess the variability of our estimate especially with small sample size, we propose a new bootstrap method for ob-taining confidence interval for this quantity. We also propose the corresponding bootstrap testing procedure to test the null hypothesis.    The second part of the dissertation is about meta-analysis in CVD research. We discover the non-normal behavior of the test statistics when sample size in each study of the meta-analysis is small. We use t distribution to approximate the underlying distribution and propose a simple formula to calculate the degree of freedom of the t distribution based on the sample size in each study as well as the number of studies.     Finally, we modify a new clinical design called Simultaneous Global Drug Development Program (SGDDP) which can be more efficient for evaluating the treatment effect on diseases such as CVD where ethnicity  have a potential impact. We add an additional as-sumption to the original test to make it unbiased. We also show the performance of the program after the modification.
4H-silicon carbide MOSFET interface structure, defect states and inversion layer mobility
Creators: name: Liu, Gang
Publisher: name: No Publisher Supplied
Year: 2014

description: Silicon carbide is the only wide band gap semiconductor that has a native oxide, and a leading candidate for development of next-generation, energy efficient, high power metal-oxide-semiconductor field effect transistors (MOSFETs). Progress in this technology has been limited by the semiconductor-dielectric interface structure and its effect on the inversion layer mobility. The major objective of this dissertation is to study and improve 4H-SiC MOSFET interface structure, defect states and inversion layer mobility on the (11-20) crystal face of SiC (a-face), employing nitrogen and phosphorous passivation. We also use these results to explore the effect of reactive ion etching on the a-face, an important aspect of processing optimum power devices. We correlate electrical measurements, i.e. current-voltage (I-V) and capacitance-voltage (C-V) with physical characterization including X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), transmission electron microscopy (TEM), secondary ion mass spectrometry (SIMS) and medium energy ion scattering (MEIS).   A significant phosphorus induced inversion layer mobility enhancement of ~125 cm2/V-s is achieved, and the revisited effect of NO on the a-face of 4H-SiC yields an impressive mobility of ~85 cm2/V-s. These results indicate that N and P improves the interface both by passivation and by interfacial counter doping, with the latter mechanism more effective on the a-face than the Si-face. Interface trap density (Nit) and the mobility-temperature dependence both indicate coulomb scattering is no longer the limiting factor for the N and P annealed a-face inversion layer mobility.   The second major part of this dissertation reports the use of hydrogen annealing to implement the successful recovery of the a-face (11-20) crystal structure and the inversion layer mobility following degradation by reactive ion etching (RIE). The results impact the processing of SiC trench MOSFETs where the a-face sidewall forms a significant portion of the conducting semiconductor channel.
The relationship of gambling goals and loss/win conditions to chasing behavior during slot machine play
Creators: name: Lister, James
Publisher: name: No Publisher Supplied
Year: 2014

description: The influence of decision-making processes on risky forms of gambling behavior has been relatively unexplored. One of these processes, goal setting, may be of particular relevance, because many gamblers cite winning money as a primary motivating force for play. This dissertation explored the relationship of goal setting (subjective and objective forms) to chasing behavior. In addition, this study examined for differences in response to loss/win conditions, as well as demographic and dispositional variables. To test this hypothesis, a sample of university students was recruited (N = 121), all of who completed a survey battery and gambled on a virtual reality slot machine. All participants were provided with $20 with which to gamble, played the slots for 30 spins (roughly 5 minutes), and then were provided with an opportunity to continue or discontinue play. The decision to continue play and the number of subsequent chasing spins were the two dependent measures of interest. Males reported higher subjective goals, were more likely to decide to chase, and chased for more spins. Separate multiple logistic and multiple linear regressions were conducted to predict decision to chase and the number of chasing spins among the overall sample and by separate gender analyses. Among the overall sample, male status, degree of subjective goals, and the degree of problem gambling severity were all positively related to decision to chase and chasing spins in preliminary analyses; only male gender remained a significant predictor in both multivariate analyses. Among the female subsample, the degree of subjective goals predicted both forms of chasing behavior in preliminary and multivariate analyses, while problem gambling severity predicted decision to chase in preliminary analyses. Among the male subsample, there were no significant predictors for decision to chase or the number of chasing spins. These results demonstrate that subjective goals may play an important role in chasing behavior, particularly as a discriminating factor among females. The influence of objective goals and loss/win conditions failed to demonstrate relationships with chasing behavior. Implications for responsible gambling, social work policy and practice, and directions for future research will be discussed.
An integrated companion diagnostics assay for predicting biochemical recurrence following radical prostatectomy
Creators: name: Lee, George C.
Publisher: name: No Publisher Supplied
Year: 2014

description: The most common treatment of prostate cancer (CaP) is via radical prostatectomy (RP), of which &5,000 are performed in the United States each year. However, within the current paradigm, 15-40% of RP treatments ultimately fail in the form of biochemical recurrence (BCR) within 5 years. Gleason scoring, derived from visual inspection of tissue morphology, has been the gold standard for distinguishing aggressive CaP for over 40 years. Furthermore, the current initiative towards personalized health care has attempted to utilize an integrated predictor via molecular markers such as prostate specific c antigen (PSA) to identify men with aggressive localized CaP. However, the non-specificity of these tests has led to an over-treatment of CaP, which is responsible for increased morbidity that is both stressful and costly for the patient.     This dissertation attempts to develop the algorithms that could pave the way for a new class of integrated predictors, which can combine histomorphometric and molecular features into an integrated biomarker and present the information needed for better patient care. Our overall goal was to predict BCR in CaP patients following RP treatment. A host of novel machine learning tools were developed to create integrated diagnostic tests, including dimensionality reduction (Adaptive Dimensionality Reduction with Semi-Supervision (AdDReSS)) and data integration (Supervised Multi-view Canonical Correlation Analysis (sMVCCA)) methodologies to handle complex, non-linear, high dimensional and heterogeneous biomedical data. Furthermore, the development and discovery of unique discriminatory features for differentiating aggressive CaP were necessary for the understanding of cancer progression and the foundation of an integrated biomarker. Novel histomorphometric features (Co-occurring Gland Tensors (CGTs) and Cell Orientation Entropy (COrE)) were developed to quantify important  differentiating image-based characteristics of CaP morphology. These methods were shown to outperform Kattan nomogram and Gleason scoring for predicting BCR following RP. Lastly, fusion of histomorphometry and protein expression into an integrated signature was performed via sMVCCA, and demonstrated improved identification of men with BCR following RP compared to histomorphometric and proteomic signatures alone.
Eminoscolex youngai Zicsi & Csuzdi 1986
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Opisthopora
Eudrilidae
Eminoscolex
Eminoscolex youngai

description: Eminoscolex youngai Zicsi & Csuzdi, 1986
Eminoscolex youngai Zicsi & Csuzdi, 1986a Acta Zool. Hung. 32: 189.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 17, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Discourse of institutional change
Creators: name: Kulkarni, Vaibhavi
Publisher: name: No Publisher Supplied
Year: 2014

description: This study examined messages representing three institutional orders – institutional order of the State, Profession and Corporation – to understand the process of institutional change surrounding the implementation of Electronic Health Records (EHR). An institutional change influences a host of stakeholders within an organizational field. These stakeholders include organizations representing different institutional orders, with multiple logics emerging from these orders. Institutional changes typically require modifying or replacing these existing institutional logics.  Communication plays an integral role in how institutional logics are transformed, legitimized or delegitimized within an organizational field during change. Accordingly, this study used a discursive approach to understand institutional change. It analyzed institutional messages and identified organizing visions within an organizational field. Analysis of institutional messages enabled identification of institutional logics that are established and contested by institutional orders of the State, Profession and Corporation, whereas organizing visions located change discourse within the larger inter-institutional context. This was accomplished by asking the following research questions: What are the institutional logics advanced by institutional orders of State, Profession and Corporation? What are the discursive strategies used by institutional orders to (de)legitimize institutional logics and promote their version of change? What are the dominant organizing visions arising out of the messages within the organizational field?  Institutional orders of the State and Corporation attempted to legitimize EHR-related change through logic of healthsystem efficacy, logic of operational efficacy and logic of collaboration. Institutional order of the Profession delegitimized the assertions made by the State and the Corporation by challenging their claims and advocating the logic of healthcare crises. The study found that all the institutional orders primarily used intertextual references that would aid them in establishment of their logics. At the same time, they also used intertextuality to minimize or exclude certain discourses or problematize discourses to delegitimize certain logics. Further, use of intertextuality enabled institutional orders to gain wider reach and increase the establishment of their messages. This, in turn, facilitated creation of two organizing visions – EHR technology as an impediment and EHR technology as progress. The study found that institutional change and discourse are mutually implicated, and highlighted the significance of discourse transmission and consumption to understand the dynamics of power and resistance within an organizational field.
Trinectes paulistanus
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Pleuronectiformes
Achiridae
Trinectes
Trinectes paulistanus

description: Trinectes paulistanus (Miranda Ribeiro 1915) (Fig. 8E). Slipper Sole, Southern Hogchoker; Suela Carioca, Suela Chancieta
Vouchers: UCR 1066-009 (2). Distribution: Western Atlantic Ocean; from Quintana Roo, Mexico, to northern Brazil; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) KP, Es, BF and To (Atlantic); 0–6 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2019), population trend unknown.
Literature: Villa (1982: 239, as Trinectes maculatus (Bloch & Schneider 1801) —misidentification; detailed description, including illustrations and an identification key, and information on distribution and ecology), Bussing (1998: 434; brief description, including illustrations and an identification key, and information on distribution, with a map, and ecology), van den Berghe (2015: 48; listed, including an illustration and information on distribution and ecology), Robertson & Van Tassell (2019: 4339; detailed description, including illustrations, and information on distribution, with a map, and ecology) and Angulo (2021: 44; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on pages 43-44, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788