cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Primary emotions as predictors for fear of COVID-19 in former inpatients with major depressive disorder and healthy control participants
Creators: name: Sanwald, Simon
name: Widenhorn-Müller, Katharina
name: Montag, Christian
name: Kiefer, Markus
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Corona
subject: Fear
subject: Emotion regulation
subject: Primary emotions
subject: Stressful life events
subject: Individual differences
subject: DDC 150 / Psychology
subject: DDC 610 / Medicine & health
subject: Avoidance (Psychology)
subject: COVID-19
subject: Depression
subject: Anxiety
subject: Stress, Psychological
subject: Mental health
subject: Emotional regulation
subject: Personality
subject: COVID-19
subject: Depression
subject: Stress
subject: Angst
subject: Vermeidungsreaktion
subject: Emotionsregulation
subject: Psychische Gesundheit

description: Introduction There are reports of an increase in depressive symptoms and fear during the COVID-19 pandemic, in particular in patients with depression. This study investigates factors related to fear of COVID-19 in former inpatients suffering from depression and healthy controls by assessing variables typically associated with depression and anxiety disorders, i.e. stressful life events (SLEs), the primary emotions SADNESS, PLAY and SEEKING as well as dysfunctional emotion regulation strategies with respect to suppression and reappraisal. Methods Data of n = 44 former inpatients suffering from depression and n = 49 healthy controls were collected. The study had a longitudinal design with two measurement points. Before the pandemic, SLEs, primary emotions, emotion regulation and depression severity were assessed. During the pandemic, COVID-19 associated stressors and life events, emotion regulation, depression severity and fear of COVID-19 were assessed. Results Fear of COVID-19 and depression severity during the pandemic were significantly higher in former inpatients than in healthy controls. Depression diagnosis, SLEs and depression severity before the pandemic were significant positive predictors of fear of COVID-19. The primary emotion PLAY was a significant negative predictor of fear of COVID-19. Depression severity did not change significantly in healthy controls. Conclusion The results show that risk factors for depression might be risk factors for high fear of COVID-19. In addition, a playful personality could help preventing mental stress in pandemic situations. Thus, positivity based interventions could counteract elevated fear scores during a pandemic.
Myocardial involvement and deformation abnormalities in idiopathic inflammatory myopathy assessed by CMR feature tracking
Creators: name: Kersten, Johannes
name: Güleroglu, Ahmet Muhammed
name: Rosenbohm, Angela
name: Buckert, Dominik
name: Ludolph, Albert Christian
name: Hackenbroch, Carsten
name: Beer, Meinrad
name: Bernhardt, Peter
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Idiopathic inflammatory myopathies
subject: Cardiac magnetic resonance
subject: Late gadolinium enhancement
subject: Strain imaging
subject: DDC 610 / Medicine & health

description: Abstract Background Cardiac involvement has been described in idiopathic inflammatory myopathies (IIM), including non-specific ECG and echocardiographic findings. Aim of our study was to evaluate myocardial deformation parameters in IIM and to correlate them with late gadolinium enhancement (LGE) findings using cardiac magnetic resonance imaging (CMR). Methods Forty-seven consecutive patients with histologically proven IIM were included into our study. Twenty-five healthy volunteers were used as a control group. All patients and controls underwent CMR examination using a 1.5 T scanner including functional cine and LGE imaging. After a mean follow-up of 234.7 ± 79.5 days a second CMR examination was performed in IIM patients. Results In comparison to healthy volunteers, IIM patients had lower left ventricular mass and left ventricular global radial, circumferential and longitudinal strain. There was no significant difference in left ventricular ejection fraction. Patients with LGE (N = 28) had lower left ventricular ejection fraction (p = 0.016), global right and left ventricular longitudinal strain (p = 0.014 and p = 0.005) and global left ventricular diastolic longitudinal strain rate (p = 0.001) compared to patients without LGE (N = 19). In IIM patients, a significant decrease of left ventricular ejection fraction, left ventricular mass and all measured deformation parameters was observed between baseline and follow-up CMR. Conclusion Cardiac involvement in IIM is frequent. Impairment of systolic and diastolic deformation parameters and a worsening over time can be observed. CMR is a useful tool for cardiac diagnostic work-up of these patients.
The Mottes of North Lancashire, Lonsdale and South Cumbria.
Creators: name: Higham, Mary C
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 91, 79-90
description: A review of occurrences of this type of Norman feature in the area, including an appendix (88--9) reporting additions to the SMR of motte and `burh-type' sites. IH
Help for insomnia from the app store? A standardized rating of mobile health applications claiming to target insomnia
Creators: name: Simon, Laura
name: Reimann, Josephin
name: Steubl, Lena Sophia
name: Stach, Michael
name: Spiegelhalder, Kai
name: Sander, Lasse Bosse
name: Baumeister, Harald
name: Messner, Eva-Maria
name: Terhorst, Yannik
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: apps
subject: mHealth
subject: mobile health
subject: sleep disorder
subject: systematic investigation
subject: DDC 610 / Medicine & health
subject: Telemedicine
subject: Sleep wake disorders
subject: Medical informatics applications
subject: Mobile applications
subject: Telemedizin
subject: Schlafstörung
subject: E-Health
subject: App

description: A large number of mobile health applications claiming to target insomnia are available in commercial app stores. However, limited information on the quality of these mobile health applications exists. The present study aimed to systematically search the European Google Play and Apple App Store for mobile health applications targeting insomnia, and evaluate the quality, content, evidence base and potential therapeutic benefit. Eligible mobile health applications were evaluated by two independent reviewers using the Mobile Application Rating Scale-German, which ranges from 1 – inadequate to 5 – excellent. Of 2236 identified mobile health applications, 53 were included in this study. Most mobile health applications (68%) had a moderate overall quality. Concerning the four main subscales of the Mobile Application Rating Scale-German, functionality was rated highest (M = 4.01, SD = 0.52), followed by information quality (M = 3.49, SD = 0.72), aesthetics (M = 3.31, SD = 1.04) and engagement (M = 3.02, SD = 1.03). While scientific evidence was identified for 10 mobile health applications (19%), only one study employed a randomized controlled design. Fifty mobile health applications featured sleep hygiene/psychoeducation (94%), 27 cognitive therapy (51%), 26 relaxation methods (49%), 24 stimulus control (45%), 16 sleep restriction (30%) and 24 sleep diaries (45%). Mobile health applications may have the potential to improve the care of insomnia. Yet, data on the effectiveness of mobile health applications are scarce, and this study indicates a large variance in the quality of the mobile health applications. Thus, independent information platforms are needed to provide healthcare seekers and providers with reliable information on the quality and content of mobile health applications.
Ultrasonography in dermatologic surgery : revealing the unseen for improved surgical planning
Creators: name: Crisan, Diana
name: Wortsman, Ximena
name: Alfageme, Fernando
name: Catalano, Orlando
name: Badea, Alexandru
name: Scharffetter-Kochanek, Karin
name: Sindrilaru, Anca
name: Crisan, Maria
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: DDC 610 / Medicine & health
subject: Dermatologic surgical procedures
subject: Ultrasonography
subject: Hautchirurgie
subject: Ultraschall

description: Ultrasonography (US) is a modern, in vivo imaging method, which is increasingly being used in dermatology as a complementary tool to clinical examination and dermoscopy. At higher frequencies (15 MHz and above), US is an established method for assessing benign and malignant skin lesions, locoregional staging, monitoring the therapeutic efficacy in various inflammatory skin conditions, and patient follow-up. One field, which may increasingly benefit from performant imaging techniques such as US is dermatologic surgery. Preoperative imaging of cutaneous tumors, inflammatory skin conditions (hidradenitis suppurativa, abscesses, etc.), or nail pathology provide dermatologic surgeons with relevant information for an optimal surgical planning, identifying potential complex aspects which might require interdisciplinary approaches, herein sparing unnecessary surgical interventions and increasing patients' compliance. In this review, we discuss the increasing significance of US in the field of dermatologic surgery, as well as the spectrum of cutaneous pathology where sonography can aid in the preoperative setting to provide a more precise, individualized surgical planning for better counseling to our patients and improved surgical results.
Terminal complement complex formation is associated with intervertebral disc degeneration
Creators: name: Teixeira, Graciosa Q.
name: Yong, Zhiyao
name: Goncalves, Raquel M.
name: Kuhn, Amelie
name: Riegger, Jana
name: Brisby, Helena
name: Barreto Henriksson, Helena
name: Ruf, Michael
name: Nerlich, Andreas
name: Mauer, Uwe M.
name: Ignatius, Anita
name: Brenner, Rolf E.
name: Neidlinger-Wilke, Cornelia
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Complement system
subject: DDC 610 / Medicine & health
subject: Back pain
subject: Immunity, Innate
subject: Scoliosis
subject: Inflammation
subject: Complement activation
subject: Rückenschmerz
subject: Skoliose
subject: Entzündung
subject: Komplement
subject: Angeborene Immunität

description: Purpose The complement system is a crucial part of innate immunity. Recent work demonstrated an unexpected contribution to tissue homeostasis and degeneration. This study investigated for the first time, in human disc tissues, the deposition profile of the complement activation product terminal complement complex (TCC), an inflammatory trigger and inducer of cell lysis, and its inhibitor CD59, and their correlation with the degree of disc degeneration (DD). Methods Disc biopsies were collected from patients diagnosed with DD (n = 39, age 63 ± 12) and adolescent idiopathic scoliosis (AIS, n = 10, age 17 ± 4) and compared with discs from healthy Young (n = 11, age 7 ± 7) and Elder (n = 10, age 65 ± 15) donors. Immunohistochemical detection of TCC and CD59 in nucleus pulposus (NP), annulus fibrosus (AF) and endplate (EP) was correlated with age, Pfirrmann grade and Modic changes. Results Higher percentage of TCC+ cells was detected in the NP and EP of DD compared to Elder (P < 0.05), and in the EP of Young versus Elder (P < 0.001). In DD, TCC deposition was positively correlated with Pfirrmann grade, but not with Modic changes, whereas for Young donors, a negative correlation was found with age, indicating TCC’s involvement not only in DD, but also in early stages of skeletal development. Higher CD59 positivity was found in AIS and DD groups compared to Young (P < 0.05), and it was negatively correlated with the age of the patients. Conclusion TCC deposition positively correlated with the degree of disc degeneration. A functional relevance of TCC may exist in DD, representing a potential target for new therapeutics.
Harmonization of summaries of product characteristics (SmPCs) of drugs with the same active ingredients : an evaluation of SmPCs of the most frequently prescribed active substances
Creators: name: Gahr, Maximilian
name: Connemann, Bernhard J.
name: Muche, Rainer
name: Zeiss, René
name: Wolf, Almuth
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Aut-idem
subject: Package insert
subject: Prescribing information
subject: DDC 610 / Medicine & health
subject: Generic drugs
subject: Pharmacovigilance
subject: Drugs; Prescribing
subject: Drugs, Generic
subject: Product Labeling
subject: Pharmacovigilance
subject: Generikum

description: Purpose In aut-idem or generic substitution, discrepancies between summaries of product characteristics (SmPCs) referring to the same active substance (AS) may cause difficulties regarding informed consent and medical liability. The qualitative and quantitative characteristics of such discrepancies are insufficiently studied, impeding harmonization of same-substance SmPCs and compromising safe drug treatment. Methods SmPCs of the one hundred most frequently prescribed ASs in Germany were analyzed for discrepancies in the presentation of indications (Inds) and contraindications (CInds). Inclusion and exclusion criteria of drugs/SmPCs were chosen according to the standards of the aut-idem substitution in Germany. Results According to the study protocol, we identified 1486 drugs, of which 1426 SmPCs could be obtained. 41% respectively 65% of the ASs had same-substance SmPCs that differed from the respective reference SmPC in the number of listed Inds respectively CInds. The number of listed Inds/CInds varied considerably between same-substance SmPCs with maximum ranges in Inds of 7 in amoxicillin, and in CInds of 11 in lisinopril. Many ASs had large proportions (> 50%) of associated same-substance SmPCs that differed from the respective reference SmPC. A considerable proportion of ASs had same-substance SmPCs with formal and content-related differences other than the discrepancy in the number of Inds/CInds. Conclusion This evaluation of same-substance SmPCs shows a clear lack of harmonization of same-substance SmPCs. Considering that generic substitution has become the rule and that physicians usually do not know which drug the patient receives in the pharmacy, these discrepancies raise several questions, that require a separate legal evaluation.
Clinical characteristics, treatment patterns and relapse in patients with clinical stage IS testicular cancer
Creators: name: Brandt, Maximilian Peter
name: Ruf, C.
name: Dieckmann, K. P.
name: Syring, I
name: Ruckes, C.
name: Nestler, T.
name: Schmelz, H. U.
name: Dotzauer, R.
name: Hiester, A.
name: Albers, P.
name: Nettersheim, D.
name: Bolenz, Christian
name: Loosen, S. H.
name: Heidenreich, A.
name: Pfister, D.
name: Haferkamp, A.
name: Zengerling, F.
name: Paffenholz, P.
name: GESRU Acad Testis
name: Penile Canc Grp
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Clinical stage IS
subject: Non-seminoma
subject: Seminoma
subject: Tumor markers
subject: Chemotherapy
subject: GERM-CELL TUMORS
subject: RISK-ADAPTED TREATMENT
subject: LACTATE-DEHYDROGENASE
subject: ALPHA-FETOPROTEIN
subject: SURVEILLANCE
subject: MANAGEMENT
subject: OUTCOMES
subject: DISEASE
subject: DDC 610 / Medicine & health

description: Abstract Purpose Clinical stage I (CSI) testicular germ cell tumors (TGCT) represents disease confined to the testis without metastasis and CSIS is defined as persistently elevated tumor markers (TM) after orchiectomy, indicating subclinical metastatic disease. This study aims at assessing clinical characteristics and oncological outcome in CSIS. Methods Data from five tertiary referring centers in Germany were screened. We defined correct classification of CSIS according to EAU guidelines. TM levels, treatment and relapse-free survival were assessed and differences between predefined groups (chemotherapy, correct/incorrect CSIS) were analyzed with Fisher’s exact and Chi-square test. Results Out of 2616 TGCT patients, 43 (1.6%) were CSIS. Thereof, 27 were correctly classified (cCSIS, 1.03%) and 16 incorrectly classified (iCSIS). TMs that defined cCSIS were in 12 (44.4%), 10 (37%), 3 (11.1%) and 2 (7.4%) patients AFP, ß-HCG, AFP plus ß-HCG and LDH, respectively. In the cCSIS group, six patients were seminoma and 21 non-seminoma. Treatment consisted of active surveillance, carboplatin-mono AUC7 and BEP (bleomycin, etoposide and cisplatin). No difference between cCSIS and iCSIS with respect to applied chemotherapy was found (p = 0.830). 5-year relapse-free survival was 88.9% and three patients (11%) in the cCSIS group relapsed. All underwent salvage treatment (3xBEP) with no documented death. Conclusion Around 1% of all TGCT were classified as cCSIS patients. Identification of cCSIS is of critical importance to avoid disease progression and relapses by adequate treatment. We report a high heterogeneity of treatment patterns, associated with excellent long-term survival irrespective of the initial treatment approach.
A Roman Road from Kendal to Ambleside. A field survey. Part I: Kendal to Broadgate.
Creators: name: Andrews, J S
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 91, 49-58
description: This route was rediscovered using fieldwork observation and dowsing techniques. It is described here in sections, from Watercrook to Helsfell, from Helsfell to Staveley, and from Staveley to Broadgate. There will be a report on the remaining sections of the road, from Broadgate to Ambleside, in the near future. IH
Complement as driver of systemic inflammation and organ failure in trauma, burn, and sepsis
Creators: name: Mannes, Marco
name: Schmidt, Christoph Q.
name: Nilsson, Bo
name: Ekdahl, Kristina N.
name: Huber-Lang, Markus
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Trauma
subject: Burn
subject: Sepsis
subject: Complement activation
subject: Thromboinflammation
subject: Systemic inflammation
subject: Clinical translation
subject: RESPIRATORY-DISTRESS-SYNDROME
subject: DECAY-ACCELERATING FACTOR
subject: ACUTE LUNG INJURY
subject: MONOCYTE CHEMOATTRACTANT PROTEIN-1
subject: MEMBRANE ATTACK COMPLEX
subject: INNATE IMMUNE-RESPONSE
subject: WHOLE-BLOOD MODEL
subject: C5A RECEPTOR
subject: THERMAL-INJURY
subject: C1-ESTERASE INHIBITOR
subject: DDC 610 / Medicine & health

description: Abstract Complement is one of the most ancient defense systems. It gets strongly activated immediately after acute injuries like trauma, burn, or sepsis and helps to initiate regeneration. However, uncontrolled complement activation contributes to disease progression instead of supporting healing. Such effects are perceptible not only at the site of injury but also systemically, leading to systemic activation of other intravascular cascade systems eventually causing dysfunction of several vital organs. Understanding the complement pathomechanism and its interplay with other systems is a strict requirement for exploring novel therapeutic intervention routes. Ex vivo models exploring the cross-talk with other systems are rather limited, which complicates the determination of the exact pathophysiological roles that complement has in trauma, burn, and sepsis. Literature reporting on these three conditions is often controversial regarding the importance, distribution, and temporal occurrence of complement activation products further hampering the deduction of defined pathophysiological pathways driven by complement. Nevertheless, many in vitro experiments and animal models have shown beneficial effects of complement inhibition at different levels of the cascade. In the future, not only inhibition but also a complement reconstitution therapy should be considered in prospective studies to expedite how meaningful complement-targeted interventions need to be tailored to prevent complement augmented multi-organ failure after trauma, burn, and sepsis. This review summarizes clinically relevant studies investigating the role of complement in the acute diseases trauma, burn, and sepsis with important implications for clinical translation.
Effects of Participation in a Post-Secondary Honors Program With Covariate Adjustment Using Propensity Score
Creators: name: Scott Furtwengler, Ph.D.
Publisher: name: figshare
Year: 2016
Subjects: subject: 130103 Higher Education
subject: FOS: Educational sciences

description: The present study sought to determine the extent to which participation in a postsecondary honors program affected academic achievement. Archival data were collected on three cohorts of high-achieving students at a large public university. Propensity scores were calculated on factors predicting participation in honors and used as the covariate. The Johnson–Neyman technique was used to determinethe values of the covariate on which the groups differed. The effect of participating in honors was greater for smaller propensity scores. The findings offer a positive outcome associated with participation for students at the lower end of the propensity score continuum, providing evidence to conclude that such programs are beneficial to a subset of high-achieving students.
Well-posedness and qualitative behaviour of the Mullins-Sekerka problem with ninety-degree angle boundary contact
Creators: name: Abels, Helmut
name: Rauchecker, Maximilian
name: Wilke, Mathias
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Mathematics, general
subject: EXISTENCE
subject: SPACES
subject: DDC 510 / Mathematics
subject: Mathematics
subject: FOS: Mathematics
subject: Existenz

description: Abstract We show local well-posedness for a Mullins-Sekerka system with ninety degree angle boundary contact. We will describe the motion of the moving interface by a height function over a fixed reference surface. Using the theory of maximal regularity together with a linearization of the equations and a localization argument we will prove well-posedness of the full nonlinear problem via the contraction mapping principle. Here one difficulty lies in choosing the right space for the Neumann trace of the height function and showing maximal Lp-Lq\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$L_p{-}L_q$$\end{document}-regularity for the linear problem. In the second part we show that solutions starting close to certain equilibria exist globally in time, are stable, and converge to an equilibrium solution at an exponential rate.
Exploring the structure – activity relationship on platinum nanoparticles
Creators: name: Braunwarth, Laura
name: Jung, Christoph
name: Jacob, Timo
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Reactive forcefield
subject: Oxygen reduction reaction
subject: DDC 540 / Chemistry & allied sciences
subject: Platinum
subject: Nanoparticles
subject: Structure-activity relationships (Biochemistry)
subject: Nanopartikel
subject: Struktur-Aktivitäts-Beziehung

description: The design of active and stable Pt-based nanoscale electrocatalysts for the oxygen reduction reaction (ORR) plays the central role in ameliorating the efficiency of proton exchange membrane fuel-cells towards future energy applications. On that front, theoretical studies have contributed significantly to this research area by gaining deeper insights and understanding of the ongoing processes. In this work, we present an approach capable of characterizing differently-shaped platinum nanoparticles undergoing thermally- and adsorbate-induced restructuring of the surface. Further, by performing ReaxFF-Grand Canonical Molecular Dynamics simulations we explored the water formation on these roughened (“realistic”) nanoparticles in a H2/O2 environment. Taking into consideration the coverage of oxygen-containing intermediates and occurring surface roughening the nanoparticles’ activities were explored. Hereby, we succeeded in locally resolving the water formation on the nanoparticles’ surfaces, allowing an allocation of the active sites for H2O production. We observed that exposed, low-coordinated sites as well as pit-shaped sites originating from roughening of vertices and edges are most active towards H2O formation.
Mothur tutorial
Creators: name: Vaulot, Daniel
Publisher: name: figshare
Year: 2018
Subjects: subject: 60504 Microbial Ecology
subject: FOS: Biological sciences
subject: 60205 Marine and Estuarine Ecology (incl. Marine Ichthyology)

description: The tutorial have been moved to GitHub.
Please go to : https://github.com/vaulot/metabarcodes_tutorials
Prolonged blooming season of flower plantings increases wild bee abundance and richness in agricultural landscapes
Creators: name: Neumüller, Ulrich
name: Burger, Hannah
name: Schwenninger, Hans Richard
name: Hopfenmüller, Sebastian
name: Krausch, Sabina
name: Weiß, Karin
name: Ayasse, Manfred
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Flower strips
subject: Wildflower plantings
subject: Floral resources
subject: Red List
subject: Threatened bees
subject: Agri-environment scheme
subject: DDC 570 / Life sciences
subject: Wildflowers
subject: Wildbienen

description: Flower plantings can increase the abundance of bees and improve pollination services in the surrounding landscape. However, uncertainty remains as to whether flower plantings play a role in wild bee conservation. The aim of this study has been to examine the contribution of the composition and management of flower plantings to the attraction of bees, particularly of endangered species. In a large-scale monitoring project, wild bee data were collected on 60 flower plantings and 120 semi-natural reference plots in 20 study sites over 2 years. In total, we recorded 60,335 bees belonging to 351 species. In flower plantings, bee species richness and abundance were intricately linked to high plant richness and constant blooming throughout the season. In the first year of this study, a complimentary blooming phenology of annual and perennial plants resulted in a more constant bloom on flower plantings. In the second year, partial mowing of flower plantings mid-season enhanced floral resources during the late season. As a result, bee richness and abundance in flower plantings increased from the first to the second year. Nevertheless, the compositional heterogeneity of bees over all 20 sites in Germany did not increase from the first to the second year. We conclude that diverse and constant blooming throughout the season is the most important factor for promoting bees in flower plantings. To ensure sufficient beta diversity over a large spatial scale, we recommend the adjustment of seed mixtures according to the geographical region.
A new phoretic association: Bursaphelenchus minutus (Nematoda: Parasitaphelenchidae) and Orthotomicus erosus (Coleoptera: Scolitydae) recorded on Pinus pinea (L.)
Creators: name: Torrini, Giulia
name: Strangi, Agostino
name: Paoli, Francesco
name: Binazzi, Francesco
name: Camerota, Manuela
name: Pennacchio, Fabrizio
name: Roversi, Pio F.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Biotechnology
subject: Evolutionary Biology
subject: Ecology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: A new phoretic association between Bursaphelenchus minutus and the bark beetle Orthotomicus erosus collected on Pinus pinea is described for the first time. Nematode identification was based on morphological observation and biometric measurements of males and females. Moreover, B. minutus was characterized by ITS sequences and RFLP profile.
Cuspidate A, new anti-fungal triterpenoid saponin from Lepidagathis cuspidata
Creators: name: Rattan, Rajeev
name: Fozdar, Bharat Inder
name: Gautam, Veena
name: Ritika Sharma
name: Kumar, Dinesh
name: Upendra Sharma
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: One new triterpenoid saponin named cuspidate A (1) along with a known oleanane-based triterpenoid saponin clemontanoside-C were isolated from the roots of Lepidagathis cuspidata. The structure of new compound (1) was established after detailed analysis of spectroscopic data including 1D and 2D NMR spectra. This is the first report on clemontanoside-C from this genus. These saponins were found to be effective against the selected fungal strains Aspergillus flavus, Rhizopus stolinifer, Penicillum nodatum, Aspergillus fumigates. Compound 1 showed better activity, comparable to the synthetic drug, while compound 2 showed a moderate effect against all studied fungal strains.
Development of Librarian Practices in Creation Processes of Universities Scientific Potentials
Creators: name: Savelieva, Olena
name: A. Myrhorodska
Publisher: name: figshare
Year: 2016
Subjects: Education

description: Development of library practices at creation processes of Universities scientific potentials, information analytics, bibliometric research on the example of the libraries in USA, Canada, Australia and Ukraine was considered. Actual performance of the Scientific and Technical Library of Dnipropetrovsk National University of Railway Transport named after Academician V. Lazaryan (DNURT) − focused on support of scientific research were presented.
Development of Librarian Practices in Creation Processes of Universities Scientific Potentials
Creators: name: Savelieva, Olena
name: Myrhorodska, A.
Publisher: name: figshare
Year: 2016
Subjects: Education

description: Development of library practices at creation processes of Universities scientific potentials, information analytics, bibliometric research on the example of the libraries in USA, Canada, Australia and Ukraine was considered. Actual performance of the Scientific and Technical Library of Dnipropetrovsk National University of Railway Transport named after Academician V. Lazaryan (DNURT) − focused on support of scientific research were presented.
Enhancing discovery in the MeerKAT Galaxy Cluster Legacy Survey with Machine Learning
Creators: name: Ventura, Fernando
Publisher: name: Zenodo
Year: 2024

description: The aim of this project is to identify unusual radio sources with astrophysical value in the MeerKAT Galaxy Cluster Legacy Survey (MGCLS), a SARAO Science Legacy Survey that observed  115 galaxy clusters at 1.28 GHz with $\sim \upmu$Jy/beam brightness sensitivity. We use autoencoders, which are automated unsupervised neural networks that encode an input into latent space code form and then attempt to reconstruct the input MGCLS image. Our approach to find source morphologies of interest  in upcoming surveys is key to optimal science exploitation of the expected large number of such sources that can be observed by SKA and precursor instruments. Which, coupled with the dramatic increase in recovered source complexity with MeerKAT’s excellent imaging fidelity and dynamic range, makes it challenging for traditional tools to keep up with high source density and the Big Data paradigm. The use of machine learning is a promising approach to addressing many of the challenges these high-quality images present. In addition to the technical approach, we present some of the science results from this project,  demonstrating that autoencoders can significantly reduce the work required to locate astrophysically valuable sources.
Using figshare to store and share large files
Creators: name: Holst, Frederik
name: Hardeman, Megan
name: Harja, Adrian
name: Team Figshare
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Using figshare to store and share large files - a figshare case study of Frederik Holst's Genetics and cancer research.
title: OFROM: interview avec unine15a65d
Creators: name: Delafontaine, François
name: Widmer, Aline
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.acc55ua4.v2#8c3d13d7dd296463db852de1b51a9ce75d59e2fd
2,7-substituted N-Carbazole donors on tris(2,4,6-trichlorophenyl)methyl radicals with high quantum yield
Creators: name: Chen, Lisa
name: Arnold, Mona
name: Kittel, Yonca
name: Blinder, Rémi
name: Jelezko, Fedor
name: Kühne, Alexander J. C.
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Gomberg radicals
subject: open-shell emitters
subject: trityl radicals
subject: unpaired electrons
subject: DDC 530 / Physics
subject: DDC 620 / Engineering & allied operations
subject: Phosphors
subject: Radicals (Chemistry)
subject: Freies Radikal

description: Doublet spin properties of organic open-shell luminophores evade the formation of dark triplet states, thus making radicals favorable emitters for next generation organic light-emitting diodes. However, their poor photostability and mediocre photoluminescence quantum yields (PLQYs) limit their application. In this work, two series of trityl radicals functionalized with one, two, and three 2,7-disubstituted carbazole units are presented. The authors either attach nitriles or bromines as electron-withdrawing 2,7-substituents. The resulting radical emitters exhibit outstanding optical properties. The electron-withdrawing properties of the substituents lead to a blue-shift of the emission, indicating a starting point for future emission engineering into the green spectrum. Due to the 2,7-substitution of the carbazole moiety, the radical emitters are sterically more hindered than the commonly used 3,6-substituted carbazoles. This steric hindrance reduces non-radiative decay pathways in the molecules, enhancing photostability and pushing PLQYs up to 87%. Quantum mechanical calculations elucidate the influence of the electron withdrawing substituents on the optical performance of the open-shell molecules. The authors also show that intensity borrowing from higher lying locally excited states contributes to these exceptionally high PLQYs.
A novel workflow to improve genotyping of multigene families in wildlife species: an experimental set‐up with a known model system
Creators: name: Gillingham, Mark A. F.
name: Montero, B. Karina
name: Wihelm, Kerstin
name: Grudzus, Kara
name: Sommer, Simone
name: Santos, Pablo S. C.
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: allele dropout
subject: amplicon genotyping
subject: high‐throughput sequencing
subject: multigene family
subject: open‐source genotyping pipeline
subject: PCR amplification bias
subject: sequencing bias
subject: DDC 570 / Life sciences
subject: Acàcia
subject: MHC

description: Abstract Genotyping complex multigene families in novel systems is particularly challenging. Target primers frequently amplify simultaneously multiple loci leading to high PCR and sequencing artefacts such as chimeras and allele amplification bias. Most genotyping pipelines have been validated in nonmodel systems whereby the real genotype is unknown and the generation of artefacts may be highly repeatable. Further hindering accurate genotyping, the relationship between artefacts and genotype complexity (i.e. number of alleles per genotype) within a PCR remains poorly described. Here, we investigated the latter by experimentally combining multiple known major histocompatibility complex (MHC) haplotypes of a model organism (chicken, Gallus gallus, 43 artificial genotypes with 2–13 alleles per amplicon). In addition to well‐defined ‘optimal’ primers, we simulated a nonmodel species situation by designing ‘cross‐species’ primers based on sequence data from closely related Galliform species. We applied a novel open‐source genotyping pipeline (ACACIA; https://gitlab.com/psc_santos/ACACIA), and compared its performance with another, previously published pipeline (AmpliSAS). Allele calling accuracy was higher when using ACACIA (98.5% versus 97% and 77.8% versus 75% for the ‘optimal’ and ‘cross‐species’ data sets, respectively). Systematic allele dropout of three alleles owing to primer mismatch in the ‘cross‐species’ data set explained high allele calling repeatability (100% when using ACACIA) despite low accuracy, demonstrating that repeatability can be misleading when evaluating genotyping workflows. Genotype complexity was positively associated with nonchimeric artefacts, chimeric artefacts (nonlinearly by levelling when amplifying more than 4–6 alleles) and allele amplification bias. Our study exemplifies and demonstrates pitfalls researchers should avoid to reliably genotype complex multigene families.
Propeptide big-endothelin, N-terminal-pro brain natriuretic peptide and mortality. The Ludwigshafen risk and cardiovascular health (LURIC) study
Creators: name: Gergei, Ingrid
name: Krämer, Bernhard K.
name: Scharnagl, Hubert
name: Stojakovic, Tatjana
name: März, Winfried
name: Mondorf, Ulrich
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 60506 Virology

description: Context: The endothelin system (Big-ET-1) is a key regulator in cardiovascular (CV) disease and congestive heart failure (CHF). Objectives: We have examined the incremental value of Big-ET-1 in predicting total and CV mortality next to the well-established CV risk marker N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP). Methods: Big-ET-1 and NT-proBNP were determined in 2829 participants referred for coronary angiography (follow-up 9.9 years). Results: Big-ET-1 is an independent predictor of total, CV mortality and death due to CHF. Discussion: The conjunct use of Big-ET-1 and NT-proBNP improves the risk stratification of patients with intermediate to high risk of CV death and CHF. Conclusions: Big-ET-1improves risk stratification in patients referred for coronary angiography.
Narrow stimulated resonance raman scattering and WGM lasing in small conjugated polymer particles for live cell tagging and tracking
Creators: name: Haehnle, Bastian
name: Lamla, Markus
name: Sparrer, Konstantin M. J.
name: Gather, Malte C.
name: Kuehne, Alexander J. C.
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: conjugated polymer particles
subject: laser emission
subject: live cell imaging
subject: whispering gallery modes
subject: AMPLIFIED SPONTANEOUS EMISSION
subject: DDC 530 / Physics
subject: DDC 620 / Engineering & allied operations
subject: Conjugated polymers
subject: Nanoparticles
subject: Nanopartikel

description: Abstract Conjugated polymer particles are brightly fluorescing and stable materials for live cell imaging. Combination of conjugated polymers with a whispering gallery mode (WGM) resonator allows laser emission from microscale particles. Once internalized by cells, the mode pattern of the laser emission can be used for tagging and tracking, as each laser spectrum represents a bar code to identify individual cells. However, currently these particle systems are limited by their large size, which might interfere with cellular functions. Here, stimulated resonance Raman scattering (SRRS) in small conjugated polymer microparticles is presented as a new method for generating narrow emission as an alternative to WGM‐based laser emission. This opens up spectral range for multiplexing optical readout and multicolor imaging of live cells. The synthesis of monodisperse micrometer‐sized poly(fluorene‐co‐divinylbenzene) particles is discussed and their WGM and SRRS emission are characterized. Finally, how these particles and their emission can be employed in live cell imaging and tagging is showcased.
description: Light‐emitting conjugated polymer particles with monodisperse diameters above 1 µm are developed. These particles act as whispering gallery mode (WGM) laser resonators for live cell imaging, tagging, and tracking. Particles that are too small to support WGM emission, instead, exhibit narrow laser‐like stimulated resonance Raman scattering (SRRS) emission, which is useful for multiplexed and multicolor live cell imaging. image
Using figshare to store and share large files
Creators: name: Holst, Frederik
name: Hardeman, Megan
name: Harja, Adrian
Publisher: name: figshare
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Using figshare to store and share large files - a figshare case study of Frederik Holst's Genetics and cancer research.
Using figshare to store and share large files
Creators: name: Holst, Frederik
name: Hardeman, Megan
name: Harja, Adrian
Publisher: name: figshare
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Using figshare to store and share large files - a figshare case study of Frederik Holst's Genetics and cancer research.
Zika virus replication in glioblastoma cells : electron microscopic tomography shows 3D arrangement of endoplasmic reticulum, replication organelles, and viral ribonucleoproteins
Creators: name: Wieland, Johannes
name: Frey, Stefan
name: Rupp, Ulrich
name: Essbauer, Sandra
name: Groß, Rüdiger
name: Münch, Jan
name: Walther, Paul
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Sandfly fever Turkey virus
subject: Electron microscopy
subject: STEM tomography
subject: High-pressure freezing
subject: Replication organelles
subject: Viral ribonucleoprotein
subject: DDC 610 / Medicine & health
subject: Zika virus
subject: Glioblastoma
subject: Electron microscope tomography
subject: Zika-Virus
subject: Glioblastom
subject: Elektronenmikroskopie
subject: Raster-Transmissions-Elektronenmikroskopie

description: Structural changes of two patient-derived glioblastoma cell lines after Zika virus infection were investigated using scanning transmission electron tomography on high-pressure-frozen, freeze-substituted samples. In Zika-virus-infected cells, Golgi structures were barely visible under an electron microscope, and viral factories appeared. The cytosol outside of the viral factories resembled the cytosol of uninfected cells. The viral factories contained largely deranged endoplasmic reticulum (ER), filled with many so-called replication organelles consisting of a luminal vesicle surrounded by the ER membrane. Viral capsids were observed in the vicinity of the replication organelles (cell line #12537 GB) or in ER cisternae at large distance from the replication organelles (cell line #15747 GB). Near the replication organelles, we observed many about 100-nm-long filaments that may represent viral ribonucleoprotein complexes (RNPs), which consist of the RNA genome and N protein oligomers. In addition, we compared Zika-virus-infected cells with cells infected with a phlebovirus (sandfly fever Turkey virus). Zika virions are formed in the ER, whereas phlebovirus virions are assembled in the Golgi apparatus. Our findings will help to understand the replication cycle in the virus factories and the building of the replication organelles in glioblastoma cells.
A study of the exotic pulsars in the globular cluster NGC 1851
Creators: name: Dutta, Arunima
Publisher: name: Zenodo
Year: 2024

description: The exceptionally high stellar densities in the cores of globular clusters (GCs) makes them remarkable hosts for an exotic binary pulsar population. In this talk, I will discuss a pair of massive binary pulsars in the dense globular cluster NGC 1851, observed with the MeerKAT as a part of the TRAPUM (TRAnsients and PUlsars with MeerKAT) GC Survey. Both systems consist of millisecond pulsars in eccentric orbits with massive companions, suggesting that they are the likely products of secondary exchange encounters. The first one is the second most eccentric binary pulsar in a GC and the mass of the companion suggests that it is a very massive carbon-oxygen white dwarf. The total mass of the second binary exceeds the heaviest double neutron star known in our Galaxy. It is also heavier than the most massive NS-NS merger candidate in LIGO/Virgo data. The derived companion mass places it as a compact object mass-gap candidate, with a mass larger than the largest precisely measured pulsars and smaller than the lightest known stellar-mass black holes (BHs). If the companion is identified as a massive neutron star, it would provide valuable insights into the equation of state of dense nuclear matter, leading to new constraints. On the other hand, if it is identified as a black hole, it would signify the discovery of the first millisecond pulsar-BH system. This would offer a unique opportunity to test the properties and formation mechanisms of black holes.
3D-XGuide: open-source X-ray navigation guidance system
Creators: name: Vernikouskaya, Ina
name: Bertsche, Dagmar
name: Rottbauer, Wolfgang
name: Rasche, Volker
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Image-guided interventions
subject: X-ray fluoroscopy
subject: Image fusion
subject: Multimodal visualization
subject: DDC 610 / Medicine & health
subject: DDC 620 / Engineering & allied operations
subject: Open source software
subject: Image registration
subject: Multimodal Imaging
subject: Registrierung (Bildverarbeitung)

description: Abstract Purpose With the growing availability and variety of imaging modalities, new methods of intraoperative support have become available for all kinds of interventions. The basic principles of image fusion and image guidance have been widely adopted and are commercialized through a number of platforms. Although multimodal systems have been found to be useful for guiding interventional procedures, they all have their limitations. The integration of more advanced guidance techniques into the product functionality is, however, not easy due to the proprietary solutions of the vendors. Therefore, the purpose of this work is to introduce a software system for image fusion, real-time navigation, and working points documentation during transcatheter interventions performed under X-ray (XR) guidance. Methods An interactive software system for cross-modal registration and image fusion of XR fluoroscopy with CT or MRI-derived anatomic 3D models is implemented using Qt application framework and VTK visualization pipeline. DICOM data can be imported in retrospective mode. Live XR data input is realized by a video capture card application interface. Results The actual software release offers a graphical user interface with basic functionality including data import and handling, calculation of projection geometry and transformations between related coordinate systems, rigid 3D-3D registration, and template matching-based tracking and motion compensation algorithms in 2D and 3D. The link to the actual software release on GitHub including source code and executable is provided to support independent research and development in the field of intervention guidance. Conclusion The introduced system provides a common foundation for the rapid prototyping of new approaches in the field of XR fluoroscopic guidance. As a pure software solution, the developed system is potentially vendor-independent and can be easily extended to be used with the XR systems of different manufacturers.