A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
Creators: name: Farmaki, Aliki-Eleni
name: Hui, Jennie
name: Gräßler, Jürgen
name: Van Der Most, Peter J.
name: Walker, Ryan W.
name: Cupples, L Adrienne
name: Holmen, Oddgeir
name: Hassinen, Maija
name: Pedersen, Oluf
name: Lichtner, Peter
name: Tachmazidou, Ioanna
name: Hillege, Hans
name: Tremblay, Angelo
name: Musk, Arthur W.
name: Heard-Costa, Nancy L.
name: Sørensen, Thorkild I. A.
name: Völker, Uwe
name: Sebert, Sylvain
name: Eriksson, Joel
name: Bellis, Claire
name: Willemsen, Gonneke
name: Chen, Yii-Der Ida
name: Hofman, Albert
name: Pankow, James S.
name: Huffman, Jennifer E.
name: Boehnke, Michael
name: Jeff, Janina M.
name: Qi, Lu
name: Thorsteinsdottir, Unnur
name: Hunter, David J.
name: Ried, Janina S.
name: Monda, Keri L.
name: Hirschhorn, Joel N.
name: Uusitupa, Matti
name: Grarup, Niels
name: Salvi, Erika
name: Mccarthy, Mark I.
name: Laakso, Markku
name: Wright, Alan F.
name: Feitosa, Mary F.
name: Stefansson, Kari
name: Widén, Elisabeth
name: Friedrich, Nele
name: O'connell, Jeffrey R.
name: Kyriakou, Theodosios
name: Lyssenko, Valeriya
name: Zeggini, Eleftheria
name: Teumer, Alexander
name: Justice, Anne E.
name: Cadby, Gemma
name: Hu, Frank
name: Lindström, Jaana
name: Tee Khaw, Kay
name: Kovacs, Peter
name: Marie Justesen, Johanne
name: Mcardle, Wendy L.
name: Willems, Sara M.
name: Stringham, Heather M.
name: Montasser, May E.
name: Kuh, Diana
name: Isaacs, Aaron
name: Karaleftheri, Maria
name: Scott, Robert A.
name: Rauramaa, Rainer
name: Jokinen, Eero
name: Schlessinger, David
name: Pilia, Maria G.
name: North, Kari E.
name: Ong, Ken K.
name: Ittermann, Till
name: Lorbeer, Roberto
name: Couto Alves, Alexessander
name: Salomaa, Veikko
name: Luben, Robert
name: Hartman, Catharina A.
name: Bouchard, Claude
name: Rayner, Nigel W.
name: Hayward, Caroline
name: Rao, 
name: Ridker, Paul M.
name: Peters, Annette
name: Hveem, Kristian
name: Vohl, Marie-Claude
name: Ribel-Madsen, Rasmus
name: Albrecht, Eva
name: Wilsgaard, Tom
name: Lorentzon, Mattias
name: Fox, Caroline
name: Palmer, Lyle J.
name: Stolk, Ronald P.
name: Carola Zillikens, 
name: Stirrups, Kathleen
name: Southam, Lorraine
name: Chasman, Daniel I.
name: Forouhi, Nita G.
name: Ryan, Kathy A.
name: Esko, Toñu
name: Linneberg, Allan
name: Hastie, Nicholas
name: Wild, Sarah H.
name: Palotie, Aarno
name: Mohlke, Karen L.
name: Wareham, Nicholas J.
name: Lakka, Timo A.
name: Koistinen, Heikki A.
name: Paternoster, Lavinia
name: Prokopenko, Inga
name: Osmond, Clive
name: Oostra, Ben A.
name: Borecki, Ingrid B.
name: Tuomilehto, Jaakko
name: Van Dongen, Jenny
name: Collins, Francis S
name: Grallert, Harald
name: Bragg-Gresham, Jennifer L.
name: Smith, Megan T.
name: Medina-Gomez, Carolina
name: Boerwinkle, Eric
name: Müller, Gabriele
name: Bornstein, Stefan R.
name: Heliövaara, Markku
name: Jousilahti, Pekka
name: Kinnunen, Leena
name: Kooner, Jaspal S.
name: Swift, Amy J.
name: Kuusisto, Johanna
name: Loos, Ruth J. F.
name: Zhao, Jing Hua
name: Ju Sung, Yun
name: Rankinen, Tuomo
name: Grewal, Jagvir
name: Bartz, Traci M.
name: Hamsten, Anders
name: Döring, Angela
name: Hicks, Andrew A.
name: Mägi, Reedik
name: Njølstad, Inger
name: Rudan, Igor
name: Rice, Treva K.
name: Strachan, David P.
name: De Geus, Eco J.C.
name: Chiang, Charleston W. K.
name: Watkins, Hugh
name: Kaplan, Robert C.
name: Blüher, Matthias
name: Standáková, Alena
name: Luan, Jian'an
name: Cusi, Daniele
name: Homuth, Georg
name: Sarzynski, Mark A.
name: Jarvelin, Marjo-Riitta
name: Ohlsson, Claes
name: Stumvoll, Michael
name: Groop, Leif C.
name: Chambers, John C.
name: Gjesing, Anette Prior
name: Penninx, Brenda W.
name: Bruinenberg, Marcel
name: Strauch, Konstantin
name: Waeber, Gérard
name: Knekt, Paul B.
name: Kolcic, Ivana
name: Husemoen, Lise Lotte
name: Dedoussis, George
name: Mahajan, Anubha
name: Fischer, Krista
name: Chu, Audrey Y.
name: Lahti, Jari
name: Lehtimäki, Terho
name: Morris, Andrew P.
name: Nolte, Ilja M.
name: Havulinna, Aki S.
name: Spector, Timothy D.
name: Vitart, Veronique
name: Keinanen-Kiukaanniemi, Sirkka M.
name: Gieger, Christian
name: Abecasis, Goncalo R.
name: Metspalu, Andres
name: Sanna, Serena
name: Psaty, Bruce M.
name: Goel, Anuj
name: Thorleifsson, Gudmar
name: Scholtens, Salome
name: Ferreira, Teresa
name: Viikari, Jorma S.
name: Lewin, Alexandra M.
name: Glorioso, Nicola
name: Mcknight, Barbara
name: Richards, Marcus
name: Winkler, Thomas W.
name: Snieder, Harold
name: Männistö, Satu
name: Kähönen, Mika
name: Harder, Marie Neergaard
name: Laitinen, Tomi
name: Bergmann, Sven
name: Oldehinkel, Albertine J.
name: Langenberg, Claudia
name: Wilson, James F.
name: Pérusse, Louis
name: Kutalik, Zoltán
name: Dimitriou, Maria
name: Farrall, Martin
name: Zhang, Weihua
name: Tönjes, Anke
name: Wang, Sophie R.
name: Verweij, Niek
name: Jackson, Anne U.
name: Lindgren, Cecilia M.
name: Bonnycastle, Lori L.
name: Narisu, Narisu
name: Eklund, Niina
name: Müller-Nurasyid, Martina
name: Polašek, Ozren
name: Kooner, Ishminder K.
name: Pichler, Irene
name: Pramstaller, Peter P.
name: Smit, Jan H.
name: Perola, Markus
name: Tsafantakis, Emmanouil
name: Beilby, John
name: Rivadeneira, Fernando
name: Sparsø, Thomas Hempel
name: Steinthorsdottir, Valgerdur
name: Graff, Mariaelisa
name: Manunta, Paolo
name: Wong, Andrew
name: Hottenga, Jouke-Jan
name: Raitakari, Olli T
name: Leach, Irene Mateo
name: Milani, Lili
name: Swertz, Morris A.
name: Boomsma, Dorret I.
name: Yerges-Armstrong, Laura M.
name: James, Alan L.
name: Ahluwalia, Tarunveer S.
name: Vartiainen, Erkki
name: Blangero, John
name: Campbell, Harry
name: Uitterlinden, André G.
name: Puolijoki, Hannu
name: Frayling, Timothy
name: Jula, Antti
name: Kristiansson, Kati
name: Eriksson, Johan G.
name: Gansevoort, Ron T.
name: Heid, Iris M.
name: Kajantie, Eero
name: Bakker, Stephan J. L.
name: Rose, Lynda M.
name: Gorski, Mathias
name: Mangino, Massimo
name: Vollenweider, Peter
name: Van Der Harst, Pim
name: Van Duijn, Cornelia M.
name: Koskinen, Seppo
name: Venturini, Cristina
name: Van Vliet-Ostaptchouk, Jana V.
name: Mills, Rebecca
name: Jørgensen, Torben
name: Mihailov, Evelin
name: Vandenput, Liesbeth
name: Shudiner, Alan R.
name: Barlassina, Cristina
name: Hattersley, Andrew Tym
name: Chines, Peter S.
name: Hansen, Torben
name: D'avila, Francesca
name: Deloukas, Panos
name: Cucca, Fracensco
name: Vonk, Judith M.
name: Hysi, Pirro G.
name: Kanoni, Stavroula
name: Schwarz, Peter E. H.
name: Jalilzadeh, Shapour
name: Bergman, Richard N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. Our findings highlight the value of using multiple traits to define complex phenotypes for discovery, which are not captured by single-trait analyses, and may shed light onto new pathways.