cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Impact of Conditional Cash Transfers on Maternal and Newborn Health
Creators: name: Singer, Daniel
name: Sturke, Rachel
name: Gleason, Joanne
name: Koblinsky, Marge
name: Yarrow, Kristina
name: Glassman, Amanda
name: Angeles, Gustavo
name: Charles, Jodi
name: Saldana, Kelly
name: Duran, Denizhan
name: Emrey, Bob
name: Mwebsa, Winnie
name: Fleisher, Lisa
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Maternal and newborn health (MNH) is a high priority for global health and is included among the Millennium Development Goals (MDGs). However, the slow decline in maternal and newborn mortality jeopardizes achievements of the targets of MDGs. According to UNICEF, 60 million women give birth outside of health facilities, and family planning needs are satisfied for only 50%. Further, skilled birth attendance and the use of antenatal care are most inequitably distributed in maternal and newborn health interventions in low- and middle-income countries. Conditional cash transfer (CCT) programmes have been shown to increase health service utilization among the poorest but little is written on the effects of such programmes on maternal and newborn health. We carried out a systematic review of studies on CCT that report maternal and newborn health outcomes, including studies from 8 countries. The CCT programmes have increased antenatal visits, skilled attendance at birth, delivery at a health facility, and tetanus toxoid vaccination for mothers and reduced the incidence of low birthweight. The programmes have not had a significant impact on fertility while the impact on maternal and newborn mortality has not been well-documented thus far. Given these positive effects, we make the case for further investment in CCT programmes for maternal and newborn health, noting gaps in knowledge and providing recommendations for better design and evaluation of such programmes. We recommend more rigorous impact evaluations that document impact pathways and take factors, such as cost-effectiveness, into account.
title: Hepatocellular Carcinoma Grading: deep Learning Approach.
Creators: name: Drago, Angelica
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Liver
subject: CT
subject: Decision analysis
subject: CAD
subject: Cancer
subject: Neoplasia

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: In this work, a novel approach for supporting HCC detection and automatic grading of liver tumors with enhanced image processing algorithms and lesions segmentation on a significant amount of patients is proposed. Resulting automatic segmentations...
Time Series Analysis of Cholera in Matlab, Bangladesh, during 1988-2001
Creators: name: Ali, Mohammad
name: Kim, Deok Ryun
name: Emch, Michael
name: Yunus, Mohammad
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The study examined the impact of in-situ climatic and marine environmental variability on cholera incidence in an endemic area of Bangladesh and developed a forecasting model for understanding the magnitude of incidence. Diarrhoea surveillance data collected between 1988 and 2001were obtained from a field research site in Matlab, Bangladesh. Cholera cases were defined as Vibrio cholerae O1 isolated from faecal specimens of patients who sought care at treatment centres serving the Matlab population. Cholera incidence for 168 months was correlated with remotely-sensed sea-surface temperature (SST) and in-situ environmental data, including rainfall and ambient temperature. A seasonal autoregressive integrated moving average (SARIMA) model was used for determining the impact of climatic and environmental variability on cholera incidence and evaluating the ability of the model to forecast the magnitude of cholera. There were 4,157 cholera cases during the study period, with an average of 1.4 cases per 1,000 people. Since monthly cholera cases varied significantly by month, it was necessary to stabilize the variance of cholera incidence by computing the natural logarithm to conduct the analysis. The SARIMA model shows temporal clustering of cholera at one- and 12-month lags. There was a 6% increase in cholera incidence with a minimum temperature increase of one degree celsius in the current month. For increase of SST by one degree celsius, there was a 25% increase in the cholera incidence at currrent month and 18% increase in the cholera incidence at two months. Rainfall did not influenc to cause variation in cholera incidence during the study period. The model forecast the fluctuation of cholera incidence in Matlab reasonably well (Root mean square error, RMSE: 0.108). Thus, the ambient and sea-surface temperature-based model could be used in forecasting cholera outbreaks in Matlab.
title: Ecological determinants of gelada ranging patterns (Theropithecus gelada)
Creators: name: Piers. Hunter, Chadden
Publisher: name: University of Liverpool Repository
Year: 2023

description: The foraging ecology of a band of gelada monkeys (Theropithecus gelada) was studied in the field at Sankaber, Ethiopia, for 14 months. The field site is at high altitude (3300m) and experiences severe variation in climatic and vegetational conditions across distinct wet and dry seasons and between different microhabitats. Gelada live in a complex fission/fusion social system and occupy a unique environmental niche as the world's only graminivorous primate species. Research was directed towards examining the ecological parameters affecting the gelada's group-level behavioural ecology. The nature and distribution of gel ada food resources was found to be a more complex and influential selective force than previously acknowledged. Gelada ranging behaviour varied in relation to spatial and temporal variation in food availability and specific small scale weather patterns, but not in relation to the distribution of sleeping sites, refuges or water sources. Group size and day journey length covaried significantly between seasons and months and the strength of the correlation between the two variables was determined by levels of food availability. The rate at which the main gel ada study band underwent fission or fusion correlated to the degree in which food was patchily distributed but not direct levels of food availability. Distribution of food sources varied significantly between habitats as did levels of visibility. Gelada alarm and flight response rates were found to correlate more strongly to levels of visibility under 10 metres within each habitat than mean levels of visibility per se. Both males and females spent significantly more time feeding, (and feeding on subterranean food items specifically) in the dry season, resulting in a slightly higher mean daily calorific intake than in the wet season. It is suggested that the dry season does not represent a 'nutritional bottleneck' to the gel ada as previously thought, but does constitute a period of increased energy requirements due to seasonal variation in lactation and thermoregulation demands
title: Spectrum of pulmonary side-effects of nivolumab – retrospective analysis
Creators: name: Ip, Joana
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Lung
subject: Oncology
subject: Thorax
subject: CT
subject: CT-High Resolution
subject: PET-CT
subject: Computer Applications-Detection, diagnosis
subject: Treatment effects
subject: Cancer
subject: Drugs / Reactions
subject: Toxicity

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Nivolumab is a monoclonal antibody (anti PD-1) approvedfor the treatment of advanced melanoma, advanced non-small cell lung cancer (NSCLC), advanced renal cell carcinoma, classical Hodgkin lymphoma, advanced squamous cell carcinoma of the head and...
An Evaluation Framework for Measuring Outcomes of Dually Diagnosed Homeless Individuals in Flexible and Integrated Treatment Programs
Creators: name: Meldrum, Richard
Publisher: name: Unknown
Year: 2002

description: Homeless individuals who are dually diagnosed have generally received poor services in treatment programs. Either the programs do not integrate mental health treatment with substance abuse treatment or the integrated programs have been too rigid to address complex dual diagnosis issues. Recently, flexible and integrated treatment programs have started to crop up to address this service gap. However, these programs often lack comprehensive evaluation data. Drawing on research with a stages of change, integrated treatment program, I explore potential ways to evaluate the short- and long-term outcomes of similar programs. The development and implementation of a comprehensive evaluation strategy is an important step to assessing the value of flexible and integrated dual diagnosis treatment programs.
title: Microvascular Invasion of Hepatocellular Carcinoma: predictive value of multiphasic CT
Creators: name: Drago, Angelica
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Abdomen
subject: Liver
subject: CT
subject: Decision analysis
subject: Diagnostic procedure
subject: Neoplasia

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To investigate potential predictive CT features of microvascular invasion (MVI) in HCC...
Trautes Heim, Glück allein : Evidenzbasierte ergotherapeutische Interventionen zur Förderung der Selbständigkeit und Lebensqualität von zuhause lebenden älteren Menschen
Creators: name: Di Nicola, Tanja
name: Linke, Anita
Publisher: name: ZHAW Zürcher Hochschule für Angewandte Wissenschaften
Year: 2016
Subjects: Ergotherapie
Intervention
Zuhause leben
älterer Mensch
Selbständigkeit
ADL
IADL
Lebensqualität
615.8515: Ergotherapie

description: Hintergrund: Für ältere Menschen ist es entscheidend, ihre zusätzlichen Lebensjahre gesund, bedeutungsvoll und würdevoll zu verbringen. Auch ist ihnen sehr wichtig, möglichst lange selbständig zu bleiben und zuhause wohnen zu können.

Ziel: Evidenzbasierte ergotherapeutische Interventionen darlegen, welche die Selbständigkeit und die Lebensqualität von zuhause lebenden älteren Menschen fördern. Dies soll als Empfehlung für praktizierende Ergotherapeutinnen und Ergotherapeuten in der Schweiz dienen.

Methode: Für das systematische Literarturreview wurde in den Datenbanken AMED, CINAHL, Cochrane Library, Medline, OTDBase und OTSeeker gesucht. Ergänzt durch eine Schneeballsuche wurden 137 Studien gelesen und aufgrund der Ein- und Ausschlusskriterien neun Studien inkludiert. Diese wurden zusammengefasst und kritisch gewürdigt. Die beschriebenen Interventionen wurden den vier Interventionsmodellen nach OTIPM (Fisher, 2014) zugeordnet.

Ergebnisse: Die Interventionen sind sehr unterschiedlich aufgebaut. Keine der Interventionen bewirkt eine signifikante Verbesserung bezüglich Selbständigkeit und Lebensqualität, dennoch sind gewisse Trends ersichtlich.

Diskussion: Kompensatorische Interventionen, wie Wohnraumanpassungen und Hilfsmittelabgaben, beeinflussen die Selbständigkeit und die Lebensqualität positiv. Mit Interventionen aus dem akquisitorischen Interventionsmodell können intrinsische Faktoren verändert, bereits aufgegebene Aktivitäten wieder aufgenommen oder neue Betätigungen entwickelt werden. Die Gruppeninterventionen haben den Vorteil, dass sie nicht nur die Motivation der Teilnehmenden positiv beeinflussen, um länger aktiv zu bleiben, sondern auch die Möglichkeit bieten, Erfahrungen auszutauschen.
Electrostatic Binding and Hydrophobic Collapse of Peptide-Nucleic Acid Aggregates Quantified Using Force Spectroscopy
Creators: name: Camunas-Soler, Joan
name: Frutos, Silvia
name: Bizarro, Cristiano V.
name: de Loreno, Sara
name: Fuentes-Perez, Maria Eugenia
name: Ramsch, Roland
name: Vilchez, Susana
name: Solans, Conxita
name: Moreno-Herrero, Fernando
name: Albericio, Fernando
name: Eritja, Ramon
name: Giralt, Ernest
name: Dev, Sukhendu B.
name: Ritort, Felix
Publisher: name: arXiv
Year: 2014
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Biomolecules (q-bio.BM)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Knowledge of the mechanisms of interaction between self-aggregating peptides and nucleic acids or other polyanions is key to the understanding of many aggregation processes underlying several human diseases (e.g. Alzheimer's and Parkinson's diseases). Determining the affinity and kinetic steps of such interactions is challenging due to the competition between hydrophobic self-aggregating forces and electrostatic binding forces. Kahalalide F (KF) is an anticancer hydrophobic peptide which contains a single positive charge that confers strong aggregative properties with polyanions. This makes KF an ideal model to elucidate the mechanisms by which self-aggregation competes with binding to a strongly charged polyelectrolyte such as DNA. We use optical tweezers to apply mechanical forces to single DNA molecules and show that KF and DNA interact in a two-step kinetic process promoted by the electrostatic binding of DNA to the aggregate surface followed by the stabilization of the complex due to hydrophobic interactions. From the measured pulling curves we determine the spectrum of binding affinities, kinetic barriers and lengths of DNA segments sequestered within the KF-DNA complex. We find there is a capture distance beyond which the complex collapses into compact aggregates stabilized by strong hydrophobic forces, and discuss how the bending rigidity of the nucleic acid affects such process. We hypothesize that within an in vivo context, the enhanced electrostatic interaction of KF due to its aggregation might mediate the binding to other polyanions. The proposed methodology should be useful to quantitatively characterize other compounds or proteins in which the formation of aggregates is relevant.
description: 34 pages, 8 figures, Supplementary Information
Audiovisuelle Beeinträchtigungen im Alter
Creators: name: Händler-Schuster, Daniela
Publisher: name: Schweizer Berufsverband der Pflegefachfrauen und Pflegefachmänner
Year: 2014
Subjects: 610: Medizin und Gesundheit
610.73: Pflege

description: Die Auswirkungen einer gleichzeitigen Behinderung im Hören und Sehen (Hörsehbehinderungen) sind weitgehend unerforscht. Dadurch fehlt der professionellen Pflege evidenzbasiertes Wissen, um gezielte Pflegeangebote zu planen und umzusetzen. Eine neue Studie der ZHAW will dies ändern.
Household Management of Childhood Diarrhoea: A Population-based Study in Nicaragua
Creators: name: Zambrana, Luis Enrique
name: Weber, David J.
name: Becker-Dreps, Sylvia
name: Vilchez, Samuel
name: Reyes, Daniel
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Diarrhoea remains an important cause of mortality and morbidity among children in Nicaragua. As the majority of diarrhoeal cases are treated at home and appropriate household management can lessen severity of diarrhoea, the objective of this study was to examine household management of childhood diarrhoea. A simple random sample of households was selected from the Health and Demographic Surveillance Site-León. Parents or caretakers of children below five years of age, who developed diarrhoea (n=232), were surveyed about household diarrhoea management practices in 2011. Fifty-seven percent of children received oral rehydration therapy (ORT) in the home prior to visiting any health facility. We encountered certain practices in contradiction with WHO recommendations for the management of diarrhoea in communities: 41% of children were offered protein-rich foods less frequently during diarrhoeal episodes, 20% of children were nursed less frequently or not at all during diarrhoeal episodes, and zinc supplementation was recommended at only 39% of visits with healthcare providers. Our findings provide insights for efforts to improve the household management of childhood diarrhoea in Nicaragua.
title: Dimensionierung eines Aluminiumstrangpressprofils für die Fertigung auf einer Biegemaschine
Creators: name: Seper, Reinhard
Publisher: name: FH CAMPUS 02 (CAMPUS 02 Fachhochschule der Wirtschaft)
Year: 2023
Subjects: subject: 670 Industrielle Fertigung

description: Das Unternehmen XAL GmbH entwickelt, produziert und vertreibt Leuchtensysteme, die aus einem Aluminiumstrangpressprofil als Leuchtengehäuse bestehen. Bisher wurden ausschließlich gerade Profilsysteme hergestellt. Diese Tatsache schränkt jedoch den kreativen Gestaltungsfreiraum der ArchitektInnen und LichtplanerInnen ein. Das Ziel der Masterarbeit für die XAL GmbH lag darin, eine Lösung für ein gebogenes Leuchtenprofil zur Herstellung individueller Deckenbilder zu erarbeiten. Die Auswahl eines passenden Fertigungsverfahrens für das Biegen eines Strangpressprofils wurde durch Gegenüberstellung mehrerer Verfahren durchgeführt. Eine Simulation des Biegeprozesses mit ANSYS® WorkbenchTM ergab die ideale Profilkontur für den Biegevorgang. Das Ergebnis der Nutzwertanalyse zeigte, dass das Rollbiegeverfahren die optimale Art zur Fertigung des gebogenen Profils darstellt. Die Simulation zeigte auf, dass ein schlankes Profil ohne aufwendige Konturen für den Biegeprozess am besten geeignet ist. Durch die Arbeit konnte ein fundiertes Wissen zur Auslegung von Strangpressprofilen für den Biegevorgang erlangt werden. Aufgrund der Auswahl des Fertigungsverfahrens Rollbiegen stehen dem Unternehmen nun mehr Möglichkeiten bei der Produktrealisierung zur Verfügung. Mit der Entwicklung eines gebogenen Leuchtensystems kann sich das Unternehmen noch stärker am Markt positionieren.
description: The company XAL GmbH develops, produces and casts out luminaire systems, which use an aluminium extrusion profile as housing. The company has produced exclusively straight lined systems so far. As a result, architects and lighting designers are restricted in their individual preferences. The purpose of this study for XAL GmbH was to develop a curved housing to allow customers to create individual shapes and visual effects on ceilings. The choice for the best manufacturing method was made by comparing a few possible methods. A simulation of the bending process, done with ANSYS® WorkbenchTM, showed the best profile contour for the bending process. As a result of the utility analyses, roll bending proofed to be the most suitable manufacturing method for the company. According to the result of the simulation, the profile for the bending process has to be slim without complex contours. With this thesis the company receives a sound knowledge for the design of extrusion profiles for the roll bending process. Thanks to the manufacturing process roll bending, there are now more possibilities for the company for implementing products. The development of a curved luminaire system means a competitive advantage for the company.
Challenges and Facilitators of Community Clinical Oncology Program Participation: A Qualitative Study:
Creators: name: Song, Paula H.
name: McAlearney, Ann Scheck
name: Weiner, Bryan J.
name: Reiter, Kristin L.
name: Minasian, Lori
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Successful participation in the National Cancer Institute’s (NCI) Community Clinical Oncology Program (CCOP) can expand access to clinical trials and promote cancer treatment innovations for patients and communities otherwise removed from major cancer centers. Yet CCOP participation involves administrative, financial, and organizational challenges that can impact hospital and provider participants. This study was designed to improve our understanding of challenges associated with CCOP participation from the perspectives of involved providers, and to learn about opportunities to overcome these challenges.
title: Cardiac-MRI: characterize myocardial diseases by using the sole late enhancement sequences.
Creators: name: Carbone, Mariangela
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Haemodynamics / Flow dynamics
subject: Diagnostic procedure
subject: Ultrasound
subject: MR
subject: Cardiac
subject: Ischaemia / Infarction

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To evaluate the possibility of recognizing and characterizing myocardial heart diseases through cardiac MRI(cMRI) by only using late enhancement sequences...
OPTIFEL : altersgerechte Verpackungen
Creators: name: Brombach, Christine
name: Miescher, Susanna
name: Yildirim, Selçuk
Publisher: name: ZHAW Zürcher Hochschule für Angewandte Wissenschaften
Year: 2014
Subjects: 664: Lebensmitteltechnologie

description: Im Rahmen eines dreieinhalbjährigen europäischen Forschungsprojekts (OPTIFEL) soll durch Entwicklung bedarfsangepasster Lebensmittel und deren altersgerechter Verpackung einer möglichen Fehlernährung im Alter entgegengewirkt werden. Als eine von 27 Partnern des EU-Projektes übernimmt die ZHAW die Umsetzung von konsumentenfreundlichen und einfach zu öffnenden Verpackungslösungen.
title: The Diagnostic Value of DCE-MRI for Muscular Invasive and Staging in Bladder Cancer
Creators: name: Chen, Xue Jun
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Urinary Tract / Bladder
subject: MR-Diffusion/Perfusion
subject: Diagnostic procedure
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The aim of this study was to explore the diagnostic efficiency of dynamic enhanced MRI (DCE-MRI) sequences in bladder cancer, to distinguish between the normal bladder wall and bladder cancer tissue, and to find the correlation between quantitative...
Aedes (Stegomyia) argenteus Poiret
Creators: name: F. W. Edwards
Publisher: name: Zenodo
Year: 1920
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Culicidae
Aedes
Aedes argenteus

description: Aedes (Stegomyia) argenteus, Poiret (fasdata, Fb.). Culex insatiabilis, Bigot, Ann. Soc. Ent. France, (3) vii, p. 11 8 (1859 ). Bigot's description and figure can apparently only apply to this species, which is common on the islands, especially near the coast (d'Emmerez de Charmoy).
description: Published as part of F. W. Edwards, 1920, Bulletin of Entomological Research, pp. 133-138 in Bulletin of Entomological Research 11 (2) on page 4, DOI: 10.1017/S0007485300044539, http://zenodo.org/record/163545
Tensor Network Implementation of Bulk Entanglement Spectrum
Creators: name: Hsieh, Timothy H.
name: Fu, Liang
name: Qi, Xiao-Liang
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Many topologically nontrivial states of matter possess gapless degrees of freedom on the boundary, and when these boundary states delocalize into the bulk, a phase transition occurs and the system becomes topologically trivial. We show that tensor networks provide a natural framework for analyzing such topological phase transitions in terms of the boundary degrees of freedom which mediate it. To do so, we make use of a correspondence between a topologically nontrivial ground state and its phase transition to a trivial phase established in [1]. This involved computing the bulk entanglement spectrum (BES) of the ground state, upon tracing out an extensive subsystem. This work implements BES via tensor network representations of ground states. In this framework, the universality class of the quantum critical entanglement Hamiltonian in d spatial dimensions is either derived analytically or mapped to a classical statistical model in d + 1 dimensions, which can be studied using Monte Carlo or tensor renormalization group methods. As an example, we analytically derive the universality classes of topological phase transitions from the spin-1 chain Haldane phase and demonstrate that the AKLT wavefunction (and its generalizations) remarkably contains critical six-vertex (and in general eight-vertex) models within it.
description: 5 pages, 4 figures, 2 pages of Supplementary Material
Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells
Creators: name: Jones, Hannah M
name: Zhou, Chunxiao
name: Stine, Jessica E
name: Bae-Jump, Victoria L
name: Han, Xiaoyun
name: Schointuch, Monica N
name: Jackson, Amanda L
name: Sheng, Xiugui
name: Kilgore, Joshua
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: High rates of aerobic glycolysis represent a key mechanism by which endometrial cancer cells consume glucose as its primary energy source. The up-regulated glycolytic pathway is a common therapeutic target whose inhibition has implications for anti-tumor activity in cancer cells. The present study was aimed at evaluating the potential of a novel lactate dehydrogenase (LDH) inhibitor, Galloflavin, as a therapeutic agent for endometrial cancer. Our results revealed that Galloflavin effectively inhibited cell growth in endometrial cancer cell lines and primary cultures of human endometrial cancer through its involvement in multiple signaling pathways that regulate metabolism, cell cycle, apoptosis, cell stress and metastasis.Electronic supplementary materialThe online version of this article (doi:10.1186/s13045-014-0097-x) contains supplementary material, which is available to authorized users.
Sipari gotici. Lo strano caso del Dr. Boaden e Mr. Lewis
Creators: name: Pepe, Paolo
Publisher: name: Roma : Carocci
Year: 2013
Subjects: Gothic
Fiction
Stage

description: Starting from the remarkable intellectual bond linking James Boaden and Matthew Gregory Lewis, this paper investigates the nature of the relationship that, at the end of the eighteenth century, came to be established between the theatrical adaptations of the most popular Gothic novels and Gothic “original” plays. The fact that most authors adapting Gothic novels for the theatre make a show of constructing a “gothicising” kind of drama, conveying a certain cultural and social respectability, is interpreted here as a deliberate attempt at defusing a genre, both narrative and theatrical, that was perceived as subversive and anti-nationalistic. In this effort towards normalization, one can see the reflections of a question of identity that runs through the society of the time and that goes beyond the field of literature, even while involving it.
title: The primary application of S-Detect technology in the diagnosis of thyroid tumors
Creators: name: han, hong
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Thyroid / Parathyroids
subject: Ultrasound
subject: Technical aspects
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Thyroid neoplasms are clinically common diseases, and ultrasound has been considered to be the best diagnostic choice in the initial assessment for thyroid nodules[1]. While the number of thyroid US examination has been increasing rapidly, the...
Achievable Regions for Interference Channels with Generalized and Intermittent Feedback
Creators: name: Zaidi, Abdellatif
Publisher: name: arXiv
Year: 2014
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: In this paper, we first study a two-user interference channel with generalized feedback. We establish an inner bound on its capacity region. The coding scheme that we employ for the inner bound is based on an appropriate combination of Han-Kobayash rate splitting and compress-and-forward at the senders. Each sender compresses the channel output that is observes using a compression scheme that is à-la Lim et al. noisy network coding and Avestimeher et al. quantize-map-and-forward. Next, we study an injective deterministic model in which the senders obtain output feedback only intermittently. Specializing the coding scheme of the model with generalized feedback to this scenario, we obtain useful insights onto effective ways of combining noisy network coding with interference alignment techniques. We also apply our results to linear deterministic interference channels with intermittent feedback.
description: To appear in Proc. of the 2014 IEEE International Symposium on Information Theory, 6 pages, 2 figures
title: The Diagnostic Value of high-resolution DWI for Muscular Invasive and Staging in Bladder Cancer
Creators: name: zhang, xiaoxian
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Urinary Tract / Bladder
subject: MR-Diffusion/Perfusion
subject: Diagnostic procedure
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The aim of this study was to compare the image quality between high-resolution diffusion weighted imaging(DWI) and routine diffusion-weighted imaging in bladder cancer, to explore the diagnostic efficiency of high-resolution DWI sequences in bladder...
The Carlina-type diluted telescope: Stellar fringes on Deneb
Creators: name: Coroller, H. Le
name: Dejonghe, J.
name: Hespeels, F.
name: Arnold, L.
name: Andersen, T.
name: Deram, P.
name: Ricci, D.
name: Berio, P.
name: Blazit, A.
name: Clausse, J-M.
name: Guillaume, C.
name: Meunier, J-P.
name: Regal, X.
name: Sottile, R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Context. The performance of interferometers has largely been increased over the last ten years. But the number of observable objects is still limited due to the low sensitivity and imaging capability of the current facilities. Studies have been done to propose a new generation of interferometers. Aims. The Carlina concept studied at the Haute-Provence Observatory consists in an optical interferometer configured as a diluted version of the Arecibo radio telescope: above the diluted primary mirror made of fixed co-spherical segments, a helium balloon or cables suspended between two mountains and/or pylons, carries a gondola containing the focal optics. This concept does not require delay lines. Methods. Since 2003, we have been building a technical demonstrator of this diluted telescope. The main goals of this project were to find the opto-mechanical solutions to stabilize the optics attached under cables at several tens of meters above the ground, and to characterize this diluted telescope under real conditions. In 2012, we have obtained metrology fringes, and co-spherized the primary mirrors within one micron accuracy. In 2013, we have tested the whole optical train: servo loop, metrology, and the focal gondola. Results. We obtained stellar fringes on Deneb in September 2013. In this paper, we present the characteristics of these observations: quality of the guiding, S /N reached, and possible improvements for a future system. Conclusions. It is an important step that demonstrates the feasibility of building a diluted telescope using cables strained between cliffs or pylons. Carlina, like the MMT or LBT, could be one of the first members of a new class of telescopes named Large Diluted Telescopes. Its optical architecture has many advantages for future projects: Planet Formation Imager, Post-ELTs, Interferometer in space.
description: 8 pages, 7 figures, Astronomy & Astrophysics
Facile and Efficient Reprogramming of Ciliary Body Epithelial Cells into Induced Pluripotent Stem Cells
Creators: name: Chavala, Sai H.
name: Ni, Aiguo
name: Wu, Ming Jing
name: Nakanishi, Yuka
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Induced pluripotent stem (iPS) cells are attractive for cell replacement therapy, because they overcome ethical and immune rejection issues that are associated with embryonic stem cells. iPS cells have been derived from autonomous fibroblasts at low efficiency using multiple ectopic transcription factors. Recent evidence suggests that the epigenome of donor cell sources plays an important role in the reprogramming and differentiation characteristics of iPS cells. Thus, identification of somatic cell types that are easily accessible and are more amenable for cellular reprogramming is critical for regenerative medicine applications. Here, we identify ciliary body epithelial cells (CECs) as a new cell type for iPS cell generation that has higher reprogramming efficiency compared with fibroblasts. The ciliary body is composed of epithelial cells that are located in the anterior portion of the eye at the level of the lens and is readily surgically accessible. CECs also have a reduced reprogramming requirement, as we demonstrate that ectopic Sox2 and c-Myc are dispensable. Enhanced reprogramming efficiency may be due to increased basal levels of Sox2 in CECs. In addition, we are the first to report a cellular reprogramming haploinsufficiency observed when reprogramming with fewer factors (Oct4 and Klf4) in Sox2 hemizygous cells. Taken together, endogenous Sox2 levels are critical for the enhanced efficiency and reduced exogenous requirement that permit facile cellular reprogramming of CECs.
title: Atypical Presentation of Microcrystal Deposition Disease: a Pictorial Essay
Creators: name: Pereira, Renata
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Diagnostic procedure
subject: MR
subject: CT-High Resolution
subject: CT
subject: Musculoskeletal soft tissue
subject: Musculoskeletal joint
subject: Musculoskeletal bone
subject: Education
subject: Arthritides

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: •To review the main diseases related to microcrystals deposit and their usual radiological aspects. •To demonstrate through a pictorial essay of cases of atypical presentation of microcystic deposit related diseases, correlating the various...
Ground-State Transcriptional Requirements for Skin-Derived Precursors
Creators: name: Labosky, Patricia A.
name: Mundell, Nathan A.
name: Pevny, Larysa H.
name: Suflita, Michael T.
name: Pfaltzgraff, Elise R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Skin-derived precursors (SKPs) are an attractive stem cell model for cell-based therapies. SKPs can be readily generated from embryonic and adult mice and adult humans, exhibit a high degree of multipotency, and have the potential to serve as a patient autologous stem cell. The advancement of these cells toward therapeutic use depends on the ability to control precisely the self-renewal and differentiation of SKPs. Here we show that two well-known stem cell factors, Foxd3 and Sox2, are critical regulators of the stem cell properties of SKPs. Deletion of Foxd3 completely abolishes the sphere-forming potential of these cells. In the absence of Sox2, SKP spheres can be formed, but with reduced size and frequency. Our results provide entry points into the gene regulatory networks dictating SKP behavior, and pave the way for future studies on a therapeutically relevant stem cell.
Reflections on Cultural Matching in Direct Practice
Creators: name: Perez, Rose M.
name: Ibarra, Gabriela
name: Leon, Rafael
Publisher: name: Unknown
Year: 2002

description: The benefit of cultural matching between clients and therapists is a topic that has received little attention in the research literature. In light of recent demographic changes in American society and the increasing diversity of the social work client population, this issue is worth exploring. A group of Latino social work students at the School of Social Service Administration at the University of Chicago decided to explore this issue by interviewing a family with whom they felt they culturally matched. In this article, they describe their experience in interviewing the family and delineate some of the advantages of their being culturally matched. Implications for practice are offered.
Joint TGF-β Type II Receptor-Expressing Cells: Ontogeny and Characterization as Joint Progenitors
Creators: name: Temple, Joseph D.
name: Li, Tieshi
name: Ozkan, Huseyin
name: Chandler, Ronald L.
name: Contaldo, Clara
name: Longobardi, Lara
name: Myers, Timothy J.
name: Spagnoli, Anna
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: TGF-β type II receptor (Tgfbr2) signaling plays an essential role in joint-element development. The Tgfbr2PRX-1KO mouse, in which the Tgfbr2 is conditionally inactivated in developing limbs, lacks interphalangeal joints and tendons. In this study, we used the Tgfbr2-β-Gal-GFP-BAC mouse as a LacZ/green fluorescent protein (GFP)-based read-out to determine: the spatial and temporally regulated expression pattern of Tgfbr2-expressing cells within joint elements; their expression profile; and their slow-cycling labeling with bromodeoxyuridine (BrdU). Tgfbr2-β-Gal activity was first detected at embryonic day (E) 13.5 within the interphalangeal joint interzone. By E16.5, and throughout adulthood, Tgfbr2-expressing cells clustered in a contiguous niche that comprises the groove of Ranvier and the synovio-entheseal complex including part of the perichondrium, the synovium, the articular cartilage superficial layer, and the tendon's entheses. Tgfbr2-expressing cells were found in the synovio-entheseal complex niche with similar temporal pattern in the knee, where they were also detected in meniscal surface, ligaments, and the synovial lining of the infrapatellar fat pad. Tgfbr2-β-Gal-positive cells were positive for phospho-Smad2, signifying that the Tgfbr2 reporter was accurate. Developmental-stage studies showed that Tgfbr2 expression was in synchrony with expression of joint-morphogenic genes such as Noggin, GDF5, Notch1, and Jagged1. Prenatal and postnatal BrdU-incorporation studies showed that within this synovio-entheseal-articular-cartilage niche most of the Tgfbr2-expressing cells labeled as slow-proliferating cells, namely, stem/progenitor cells. Tgfbr2-positive cells, isolated from embryonic limb mesenchyme, expressed joint progenitor markers in a time- and TGF-β-dependent manner. Our studies provide evidence that joint Tgfbr2-expressing cells have anatomical, ontogenic, slow-cycling trait and in-vivo and ex-vivo expression profiles of progenitor joint cells.
Fast-Proliferating Adipose Tissue Mesenchymal-Stromal-Like Cells for Therapy
Creators: name: Rubio, Nuria
name: Bagó, Julio Rodriguez
name: Aguilar, Elisabet
name: Blanco, Jeronimo
name: Alieva, Maria
name: Rigola, Maria Angeles
name: Fuster, Carme
name: Soler-Botija, Carol
name: Vila, Olaia F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Human mesenchymal stromal cells, whether from the bone marrow or adipose tissue (hASCs), are promising cell therapy agents. However, generation of abundant cells for therapy remains to be a challenge, due to the need of lengthy expansion and the risk of accumulating genomic defects during the process. We show that hASCs can be easily induced to a reversible fast-proliferating phenotype (FP-ASCs) that allows rapid generation of a clinically useful quantity of cells in <2 weeks of culture. Expanded FP-ASCs retain their finite expansion capacity and pluripotent properties. Despite the high proliferation rate, FP-ASCs show genomic stability by array-comparative genomic hybridization, and did not generate tumors when implanted for a long time in an SCID mouse model. Comparative analysis of gene expression patterns revealed a set of genes that can be used to characterize FP-ASCs and distinguish them from hASCs. As potential candidate therapeutic agents, FP-ASCs displayed high vasculogenic capacity in Matrigel assays. Moreover, application of hASCs and FP-ASCs in a fibrin scaffold over a myocardium infarct model in SCID mice showed that both cell types can differentiate to endothelial and myocardium lineages, although FP-ASCs were more potent angiogenesis inducers than hASCs, at promoting myocardium revascularization.
title: Transient lower enhancement of peri-tumor cortex in clear cell renal cell carcinoma: correlation with Fuhrman grade
Creators: name: Zhang, Xinghua
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Abdomen
subject: Kidney
subject: CT
subject: CT-Angiography
subject: Comparative studies
subject: Cancer
subject: Ischaemia / Infarction

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Previous studies have investigated the relationship between Fuhrman grade and imaging features on CT (1-3). Lower enhancement of tumor on CT, which was considered to represent histologic necrosis, was associated with high tumor grade of...
Sphere Formation Permits Oct4 Reprogramming of Ciliary Body Epithelial Cells into Induced Pluripotent Stem Cells
Creators: name: Wu, Ming Jing
name: Ni, Aiguo
name: Chavala, Sai H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Somatic cells can be reprogrammed to induced pluripotent stem (iPS) cells by defined sets of transcription factors. We previously described reprogramming of monolayer-cultured adult mouse ciliary body epithelial (CE) cells by Oct4 and Klf4, but not with Oct4 alone. In this study, we report that Oct4 alone is sufficient to reprogram CE cells to iPS cells through sphere formation. Furthermore, we demonstrate that sphere formation induces a partial reprogramming state characterized by expression of retinal progenitor markers, upregulation of reprogramming transcription factors, such as Sall4 and Nanog, demethylation in the promoter regions of pluripotency associated genes, and mesenchymal to epithelial transition. The Oct4-iPS cells maintained normal karyotypes, expressed markers for pluripotent stem cells, and were capable of differentiating into derivatives of all three embryonic germ layers in vivo and in vitro. These findings suggest that sphere formation may render somatic cells more susceptible to reprogramming.
title: Influence of blade width and magnetic field strength on the apparent diffusion coefficient (ADC) on PROPELLER diffusion-weighted imaging (DWI) in head and neck
Creators: name: Sumikawa, Tetsuo
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: MR-Diffusion/Perfusion
subject: Head and neck
subject: Technology assessment
subject: Image registration

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Diffusion-weighted imaging (DWI) is a useful clinical tool for assessing various diseases. The apparent diffusion coefficient (ADC) reflects the molecular diffusion of water and it is used to differentiate between benign and malignant tumors...
Glycogen storage disease type III-hepatocellular carcinoma a long-term complication?
Creators: name: Chen, Y.T.
name: Gottfried, Marcia
name: Kishnani, Priya S.
name: Frush, Donald
name: Bali, Deeksha
name: Boney, Anne
name: Koepke, John
name: Demo, Erin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Glycogen storage disease III (GSD III) is caused by a deficiency of glycogen-debranching enzyme which causes an incomplete glycogenolysis resulting in glycogen accumulation with abnormal structure (short outer chains resembling limit dextrin) in liver and muscle. Hepatic involvement is considered mild, self-limiting and improves with age. With increased survival, a few cases of liver cirrhosis and hepatocellular carcinoma (HCC) have been reported.
Safety of medicines during breastfeeding – from case report to modeling: a contribution from the ConcePTION project
Creators: name: Cardoso, Evelina
name: Guidi, Monia
name: Nauwelaerts, Nina
name: Nordeng, Hedvig
name: Teil, Marie
name: Allegaert, Karel
name: Smits, Anne
name: Gandia, Peggy
name: Edginton, Andrea
name: Ito, Shinya
name: Annaert, Pieter
name: Panchaud, Alice
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: Despite many research efforts, current data on the safety of medicines during breastfeeding are either fragmented or lacking, resulting in restrictive labeling of most medicines. In the absence of pharmacoepidemiologic safety studies, risk estimation for breastfed infants is mainly derived from pharmacokinetic (PK) information on medicine. This manuscript provides a description and a comparison of the different methodological approaches that can yield reliable information on medicine transfer into human milk and the resulting infant exposure. Currently, most information on medicine transfer in human milk relies on case reports or traditional PK studies, which generate data that can hardly be generalized to the population. Some methodological approaches, such as population PK (popPK) and physiologically based PK (PBPK) modeling, can be used to provide a more complete characterization of infant medicine exposure through human milk and simulate the most extreme situations while decreasing the burden of sampling in breastfeeding women. PBPK and popPK modeling are promising approaches to fill the gap in knowledge of medicine safety in breastfeeding, as illustrated with our escitalopram example.
Numerical recovery of location and residue of poles of meromorphic functions
Creators: name: De Micheli, Enrico
name: Viano, Giovanni Alberto
Publisher: name: arXiv
Year: 2014
Subjects: subject: Numerical Analysis (math.NA)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 65D05, 30E10, 41A05

description: We present a method able to recover location and residue of poles of functions meromorphic in a half--plane from samples of the function on the real positive semi-axis. The function is assumed to satisfy appropriate asymptotic conditions including, in particular, that required by Carlson's theorem. The peculiar features of the present procedure are: (i) it does not make use of the approximation of meromorphic functions by rational functions; (ii) it does not use the standard methods of regularization of ill-posed problems. The data required for the determination of the pole parameters (i.e., location and residue) are the approximate values of the meromorphic function on a finite set of equidistant points on the real positive semi-axis. We show that this method is numerically stable by proving that the algorithm is convergent as the number of data points tends to infinity and the noise on the input data goes to zero. Moreover, we can also evaluate the degree of approximation of the estimates of pole location and residue which we obtain from the knowledge of a finite number of noisy samples.
description: 33 pages, 8 figures
title: The effectiveness of full body EOS compared to conventional chest X-ray in preoperative evaluation of the chest for patients undergoing spine operations
Creators: name: Wong, Ying Mei
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Outcomes
subject: Surgery
subject: Screening
subject: Comparative studies
subject: Conventional radiography
subject: Musculoskeletal spine

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The purpose of a preoperative assessment is to evaluate the patient’s fitness for anaesthesia and surgery [1,2]. Apart from history-taking and physical examination, the chest X-ray (CXR)is an important assessment tool for the detection of numerous...