cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Experimental observation of transient δ18O interaction between snow and advective airflow under various temperature gradient conditions
Creators: name: Ebner, Pirmin
name: Steen-Larsen, Hans C.
name: Stenni, Barbara
name: Schneebeli, Martin
name: Steinfeld, Aldo
Publisher: name: ETH Zurich
Year: 2017
Subjects: snow
isotope
isothermal
metamorphism
advection
tomography
post-depositional process

description: Stable water isotopes (δ18O) obtained from snow and ice samples of polar regions are used to reconstruct past climate variability, but heat and mass transport processes can affect the isotopic composition. Here we present an experimental study on the effect on the snow isotopic composition by airflow through a snow pack in controlled laboratory conditions. The influence of isothermal and controlled temperature gradient conditions on the δ18O content in the snow and interstitial water vapor is elucidated. The observed disequilibrium between snow and vapor isotopes led to exchange of isotopes between snow and vapor under non-equilibrium processes, significantly changing the δ18O content of the snow. The type of metamorphism of the snow had a significant influence on this process. These findings are pertinent to the interpretation of the records of stable isotopes of water from ice cores. These laboratory measurements suggest that a highly resolved history is relevant for the interpretation of the snow isotopic composition in the field.
description: The Cryosphere Discussions
description: ISSN:1994-0432
description: ISSN:1994-0440
Medieval rural lead working:excavations at Linch Clough, Upper Derwent valley, 2000-01.
Creators: name: Bevan, Bill
name: Doonan, Roger C P
name: Gale, Rowena M O
Publisher: name: Archaeology Data Service
Year: 2004

description: The Derbyshire Archaeological Journal, 124, 113-140
description: Report on the excavation of a lead smelting site on moorland in the Upper Derwent Valley, indicating small-scale rural industrial activity. Features included a hearth, channel, sub-circular platform within which was a circular pit, and dumps of industrial material including lead waste, slag and burnt stones. The last use of the hearth was dated using archaeomagnetic techniques to between AD 1430--1470. The report includes an analysis and interpretation of the pyrometallurgical finds and of the charcoal. It also includes an interpretation of the site in the context of the surrounding landscape and the wider region, of available lead ore and charcoal sources, and of contemporary land ownership and settlement.
Initiation of a major calving event on Bowdoin Glacier captured by UAV photogrammetry
Creators: name: Jouvet, Guillaume
name: Weidmann, Yvo
name: Seguinot, Julien
name: Funk, Martin
name: Abe, Takahiro
name: Sakakibara, Daiki
name: Seddik, Hakime
name: Sugiyama, Shin
Publisher: name: ETH Zurich
Year: 2016

description: The Cryosphere Discussions
description: ISSN:1994-0432
description: ISSN:1994-0440
Applying the Argument Principle to the extended Riemann Siegel function components of the Riemann Zeta function
Creators: name: Martin, John
Publisher: name: figshare
Year: 2016
Subjects: subject: 10199 Pure Mathematics not elsewhere classified
subject: FOS: Mathematics

description: Applying the argument principle for contour integration of the Riemann Zeta function, using the extended Riemann Siegel function components for various s = σ + i ∗ t lines in the positive quadrant of the complex plane gives results explaining the Riemann Hypothesis. In particular, given the relationship −Im(log(ζ(s))) = θ_ext (s) − Im(log(Z_ext (s))), and that θ_ext (s) (Im(log(Z_ext (s)))) are even(odd) functions respectively about the critical line, excludes any Riemann Zeta zeroes in the upper half of the critical strip.
How accurate are estimates of glacier ice thickness? Results from ITMIX, the Ice Thickness Models Intercomparison eXperiment
Creators: name: Farinotti, Daniel
name: Brinkerhoff, Douglas J.
name: Clarke, Garry K.C.
name: Fürst, Johannes J.
name: Frey, Holger
name: Gantayat, Prateek
name: Gillet-Chaulet, Fabien
name: Girard, Claire
name: Huss, Matthias
name: Leclercq, Paul W.
name: Linsbauer, Andreas
name: Machguth, Horst
name: Martin, Carlos
name: Maussion, Fabian
name: Morlighem, Mathieu
name: Mosbeux, Cyrille
name: Pandit, Ankur
name: Portmann, Andrea
name: Rabatel, Antoine
name: Ramsankaran, Raaj
name: Reerink, Thomas J.
name: Sanchez, Olivier
name: Stentoft, Peter A.
name: Kumari, Sangita Singh
name: van Pelt, Ward J.J.
name: Anderson, Brian
name: Benham, Toby
name: Binder, Daniel
name: Dowdeswell, Julian A.
name: Fischer, Andrea
name: Helfricht, Kay
name: Kutuzov, Stanislav
name: Lavrentiev, Ivan
name: McNabb, Robert
name: Gudmundsson, Gudmundur H.
name: Li, Huilin
name: Andreassen, Liss M.
Publisher: name: ETH Zurich
Year: 2016

description: The Cryosphere Discussions
description: ISSN:1994-0432
description: ISSN:1994-0440
Gender and speech material effects on the long-term average speech spectrum, including at extended high frequencies
Creators: name: Trine, Allison
name: Delaram, Vahid
name: Miller, Margaret K.
name: Ananthanarayana, Rohit M.
name: Buss, Emily
name: Stecker, G. Christopher
name: Monson, Brian B.
Publisher: name: Acoustical Society of America (ASA)
Year: 2024

description:
Gender and language effects on the long-term average speech spectrum (LTASS) have been reported, but typically using recordings that were bandlimited and/or failed to accurately capture extended high frequencies (EHFs). Accurate characterization of the full-band LTASS is warranted given recent data on the contribution of EHFs to speech perception. The present study characterized the LTASS for high-fidelity, anechoic recordings of males and females producing Bamford-Kowal-Bench sentences, digits, and unscripted narratives. Gender had an effect on spectral levels at both ends of the spectrum: males had higher levels than females below approximately 160 Hz, owing to lower fundamental frequencies; females had ∼4 dB higher levels at EHFs, but this effect was dependent on speech material. Gender differences were also observed at ∼300 Hz, and between 800 and 1000 Hz, as previously reported. Despite differences in phonetic content, there were only small, gender-dependent differences in EHF levels across speech materials. EHF levels were highly correlated across materials, indicating relative consistency within talkers. Our findings suggest that LTASS levels at EHFs are influenced primarily by talker and gender, highlighting the need for future research to assess whether EHF cues are more audible for female speech than for male speech.
A Process–Based Rating Curve to model suspended sediment concentration in Alpine environments
Creators: name: Costa, Anna
name: Anghileri, Daniela
name: Molnar, Peter
Publisher: name: ETH Zurich
Year: 2017

description: A Process-Based Rating Curve (PBRC) approach to simulate mean daily suspended sediment concentration (SSC) as a function of different sediment sources and their activation by erosive rainfall (ER), snowmelt (SM), and icemelt (IM) in an Alpine catchment is presented. Similarly to the traditional rating curve, the PBRC relates SSC to the three main hydroclimatic variables through power functions. We obtained the hydroclimatic variables from daily gridded datasets of precipitation and temperature, implementing a degree-day model to simulate spatially distributed snow accumulation and snow-ice melt. We calibrated the PBRC parameters by an Iterative Input Selection algorithm to capture the characteristic response time lags, and by a gradient-based nonlinear optimization method to minimize the errors between SSC observations and simulations. We apply our approach in the upper Rhône Basin, a large Alpine catchment in Switzerland. Results show that all three hydroclimatic processes ER, SM, and IM are significant predictors of mean daily SSC (explaining 75 %, 12 % and 3 % of the total observed variance). Despite not using discharge in prediction, the PBRC performs better than the traditional rating curve, especially during validation at the daily scale and in reproducing SSC seasonality. The characteristic time lags of the three variables in contributing to SSC reflect the typical flow concentration times of the corresponding hydrological processes in the basin. Erosive rainfall determines the daily variability of SSC, icemelt generates the highest SSC per unit of runoff, and snowmelt-driven fluxes represent the largest contribution to total suspended sediment yield. Finally, we show that the PBRC is able to simulate changes in SSC in the past 40 years in the Rhône Basin connected to air temperature rise, even though these changes are more gradual than those detected in observations. We argue that a sediment source perspective on suspended sediment transport such as the PBRC may be more suitable than traditional discharge-based rating curves to explore climate-driven changes in fine sediment dynamics in Alpine catchments. The PBRC approach can be applied to any Alpine catchment with a pluvio-glacio-nival hydrological regime and adequate hydroclimatic datasets.
description: Hydrology and Earth System Sciences Discussions
description: ISSN:1812-2116
description: ISSN:1812-2108
title: 01_0480
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
title: 14 - Entretien avec le vieil azmari Mulu’aläm Adägä : histoire du liqä mäkwas Mersha et autres personnages de la fin du XIXe siècle.
Creators: name: Wion, Anaïs
name: Bolay, Anne
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: histoire
valueUri: ark:/12148/cb119344445
subject: liqä mäkwas
subject: ras Wubé

description: Le liqä mäkwas Mersha servit le dädjatch Wubé.
Soil properties and not inputs control carbon, nitrogen, phosphorus ratios in cropped soils in the long-term
Creators: name: Frossard, Emmanuel
name: Buchmann, Nina
name: Bünemann, Else K.
name: Kiba, Delwendé I.
name: Lompo, François
name: Oberson, Astrid
name: Tamburini, Federica
name: Traoré, Ouakoltio Y.A.
Publisher: name: ETH Zurich
Year: 2015

description: Soil Discussions, 2 (2)
Low barrier methyl rotation in 3-pentyn-1-ol as observed by microwave spectroscopy
Creators: name: Eibl, Konrad
name: Kannengießer, Raphaela
name: Stahl, Wolfgang
name: Nguyen, Ha Vinh Lam
name: Kleiner, Isabelle
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Hematology

description: The rotational spectrum of 3-pentyn-1-ol, CH3−C≡C−CH2CH2OH, was measured using a molecular beam Fourier transform microwave spectrometer operating in the frequency range from 2 to 26.5 GHz. A two-dimensional potential energy surface was calculated at the MP2/6-311++G(d,p) level of theory for a conformational analysis, yielding five conformers. The most stable conformer exhibits C1 symmetry and was assigned in the spectrum by comparison with the results from quantum chemical calculations. The barrier to internal rotation of the propynyl methyl group CH3−C≡C− was found to be only 9.4552(94) cm−1. Molecular parameters and internal rotation parameters could be accurately determined using the program xiam and belgi-C1. The internal rotation barrier was compared with those of other molecules containing a propynyl methyl group.
title: 15 - Entretien avec le vieil azmari Mulu’aläm Adägä
Creators: name: Wion, Anaïs
name: Bolay, Anne
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: chant
subject: ras Makwonnen
valueUri: ark:/12148/cb162403229

description: Bälay Mäkkätä se souvient d’une strophe sur le ras Makwonnen.
Theoretical study of cooperativity between hydrogen bond‒hydrogen bond, halogen bond‒halogen bond and hydrogen bond‒halogen bond in ternary FX…diazine…XF (X = H and Cl) complexes
Creators: name: Masoodi, Hamid Reza
name: Sotoodeh Bagheri
name: Mahdiyeh Ranjbar
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: In the present work, the cooperativity between hydrogen bond‒hydrogen bond, halogen bond‒halogen bond and hydrogen bond‒halogen bond in ternary FX…diazine…XF (X = H and Cl) complexes is theoretically investigated. The sign of cooperative energy (Ecoop) obtained in all of the triads is positive which indicates that the ternary complex is less stable than the sum of the two isolated binary complexes. Moreover, our calculations show that Ecoop value in triads increases as FX…pyridazine…XF > FX…pyrimidine…XF > FX…pyrazine…XF. In agreement with energetic, geometrical and topological properties, electrostatic potentials and coupling constants across 15N…X−19F (X = 1H or 35Cl) hydrogen and halogen bonds indicate that hydrogen and halogen bonds are weakened in the considered complexes where two hydrogen and halogen bonds coexist. As compared to N…H hydrogen bond, it is also observed that cooperativity has greater effect on N…Cl halogen bond.
Automatic Programming of Cellular Automata and Artificial Neural Networks Guided by Philosophy
Creators: name: Christen, Patrik
name: Del Fabbro, Olivier
Publisher: name: ETH Zurich
Year: 2019

description: Many computer models such as cellular automata have been developed and successfully applied. However, in some cases these models might be restrictive on the possible solutions or their solution is difficult to interpret. To overcome this problem, we outline an approach, the so-called allagmatic method, that automatically creates and programs models with as little limitations as possible but still maintaining human interpretability. We earlier described a meta-model and its building blocks according to the philosophical concepts of structure (spatial dimension) and operation (temporal dimension). They are entity, milieu, and update function that together abstractly describe the meta-model. By automatically combining these building blocks, new models can potentially be created in an evolutionary computation. We propose generic and object-oriented programming to implement the entities and their milieus as dynamic and generic arrays and the update function as a method. We show two experiments where a simple cellular automaton and an artificial neural network are automatically created and programmed. A target state is successfully evolved and learned in the cellular automaton and artificial neural network, respectively. We conclude that the allagmatic method can create and program cellular automaton and artificial neural network models in an automated manner.
description: arXiv
Mpox surveillance: the need for enhanced testing and genomic epidemiology
Creators: name: Wang, Jeremy R
Publisher: name: Elsevier
Year: 2024

description:
Mpox and its causative pathogen, monkeypox virus, represent a growing international public health concern following a global outbreak of monkeypox virus clade II in 2022–23 and regional outbreaks of monkeypox virus clade I centred in DR Congo beginning in late 2023. Epidemiological analysis of monkeypox virus, including genomic epidemiology, is crucial to understanding the expansion of the virus within and outside its historically endemic range due to increased spillover from a zoonotic host, increased human-to-human transmission, or both, and any changes in virulence. Robust genomic epidemiology can characterise adaptation of monkeypox virus to human hosts and inform the control of ongoing mpox epidemics and prevention of future epidemics.
title: 16 - Entretien avec le vieil azmari Mulu’aläm Adägä : chant sänga
Creators: name: Wion, Anaïs
name: Bolay, Anne
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: chant

description: Mulu’aläm Adägä prend le masinqo et chante des chants anciens (type sänga).
title: écuelle E2b (Barrier  Luginbühl 2021)
Creators: name: Luginbühl, Thierry
name: Barrier, Sylvie
Publisher: name: Conservatoire National des Données 3D (CND3D)
Year: 2024
Subjects: subject: écuelle
subject: Artefact
subject: ACQUISITION

description: Modèle 3D
Survey of a limekiln complex at Peak Forest, and review of limeburning in the NW Peak
Creators: name: Barnatt, John W
name: Dickson, Antony
Publisher: name: Archaeology Data Service
Year: 2004

description: The Derbyshire Archaeological Journal, 124, 141-215
description: Report on the survey of an early commercial limerburning complex in the north-western part of the Peak's limestone plateau. The article covers the general characteristics of the kilns and quarries; kiln typology; and a detailed description of the four quadrants into which the survey was divided. Ash-houses, roads and access tracks, and other archaeological features are described, as is the historical documentation of the complex. Analysis includes the development and chronology of the complex. The article also reviews briefly other similar archaeological sites in the vicinity and seeks to place the Peak Forest limeburning complex in context; the scale, character and chronology of limerburning in the north-west Peak between the seventeenth and nineteenth centuries is examined.
Phytochemical constituents and biological activities of Cleome iberica DC.
Creators: name: Farimani, Mahdi Moridi
name: Nazarianpoor, Emad
name: Arezoo Rustaie
name: Akhbari, Maryam
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Inorganic Chemistry
subject: Plant Biology

description: Phytochemical investigation of Cleome iberica DC. aerial parts led to the isolation and characterisation of six triterpenoid including glutinol (1), lupeol (2), β-sitosterol (3), cabraleadiol monoacetate (4), cabraleadiol (6) and daucosterol (8), one flavonoid, calycopterin (5) along with a fatty acid, tricosanoic acid (7). While studied samples showed weak potency in antimicrobial assessment, the acetone extract and some isolated compounds exhibited considerable cytotoxicity against cervical cancer cell line (HeLa) in MTT assay, among them calycopterin with IC50 equals to 5.1 μM was the strongest. The extract showed moderate antioxidant capacity in DPPH assay method (IC50 = 100.2 μg/mL) and total phenolics and total flavonoids contents of the dried extract were also determined as 39.6 and 90.7 mg/g, respectively.
Carbon Isotopes in the Ocean Model of the Community Earth System Model (CESM1)
Creators: name: Jahn, A.
name: Lindsay, Keith
name: Giraud, Xavier
name: Gruber, Nicolas
name: Otto-Bliesner, Bette L.
name: Liu, Z.
name: Brady, Esther C.
Publisher: name: ETH Zurich
Year: 2014

description: Carbon  isotopes  in  the  ocean  are  frequently  used  as  paleo  climate  proxies  and  aspresent-day geochemical ocean tracers. In order to allow a more direct comparisonof climate model results with this large and currently underutilized dataset, we added a carbon isotope module to the ocean model of the Community Earth System Model5(CESM), containing the cycling of the stable isotope13C and the radioactive isotope14C. We implemented the14C tracer in two ways: in the “abiotic” case, the14C tracer isonly subject to air–sea gas exchange, physical transport, and radioactive decay, whilein the “biotic” version, the14C additionally follows the13C tracer through all biogeo-chemical and ecological processes. Thus, the abiotic14C tracer can be run without10the ecosystem module, requiring significantly less computational resources. The car-bon isotope module calculates the carbon isotopic fractionation during gas exchange,photosynthesis, and calcium carbonate formation, while any subsequent biological pro-cess such as remineralization as well as any external inputs are assumed to occurwithout fractionation. Given the uncertainty associated with the biological fractionation15during photosynthesis, we implemented and tested three parameterizations of differ-ent complexity. Compared to present-day observations, the model is able to simulatethe oceanic14C bomb uptake and the13C Suess effect reasonably well compared toobservations and other model studies. At the same time, the carbon isotopes revealbiases in the physical model, for example a too sluggish ventilation of the deep Pacific Ocean.
description: Geoscientific Model Development Discussions, 7 (6)
description: ISSN:1991-962X
description: ISSN:1991-9611
The Manor and Prebendal Lands of Little Chester, Derby
Creators: name: D'Arcy, Joan
Publisher: name: Archaeology Data Service
Year: 2004

description: The Derbyshire Archaeological Journal, 124, 285-303
description: The article seeks to correct the assumption made by George Bailey (in articles published in Derbyshire Archaeol J 11 (1889) pp 9-14 and 12 (1890) pp 170-181) that all three of the properties described by him were former prebendal farms. The author demonstrated that although two, Stone House Prebend and Manor Farm, were indeed prebendal farmhouses, the third, now called Derwent House, had not been. It stood on manorial lands and was, in all probability, the site of the Manor House of Little Chester.
MPEC 2024-K97 : 2016 LL1
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
title: 17 - Entretien avec le vieil azmari Mulu’aläm Adägä : chant sur la mort du roi Tewodros et de sa femme Täwabätch
Creators: name: Wion, Anaïs
name: Bolay, Anne
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: chant
subject: roi Tewodros
valueUri: ark:/12148/cb119723416

description: Mutché chante un chant relatif à la mort de la femme du roi Tewodros.
Sutimlimab: First Approval
Creators: name: Dhillon, Sohita
Publisher: name: Adis Journals
Year: 2022
Subjects: Medicine

description: Declarations Funding The preparation of this review was not supported by any external funding. Authorship and Conflict of interest During the peer review process the manufacturer of the agent under review was offered an opportunity to comment on the article. Changes resulting from any comments received were made by the authors on the basis of scientific completeness and accuracy. Sohita Dhillon is a contracted employee of Adis International Ltd/Springer Nature and declares no relevant conflicts of interest. All authors contributed to the review and are responsible for the article content. Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability Not applicable. Additional information about this Adis Drug Review can be found here. Abstract Sutimlimab (sutimlimab-jome; ENJAYMO™) is a humanized monoclonal antibody developed by Sanofi for the treatment of cold agglutinin disease (CAD). Sutimlimab is an immunoglobulin G, subclass 4 (IgG4) monoclonal antibody that inhibits the classical complement pathway by binding to complement protein component 1, s subcomponent (C1s), a serine protease which cleaves C4 and C2 to form the C3 convertase. Inhibition of the classical complement pathway at the level of C1s prevents deposition of complement opsonins on the surface of red blood cell (RBCs), leading to inhibition of haemolysis in patients with CAD. In February 2022, sutimlimab received its first approval in the USA to decrease the need for RBC transfusion due to haemolysis in adults with CAD. Sutimlimab is under regulatory review in Japan and the EU for CAD. This article summarizes the milestones in the development of sutimlimab leading to this first approval for CAD. © Springer Nature Switzerland AG 2022
A Framework for Synthetic Control Methods With High-Dimensional, Micro-Level Data: Evaluating a Neighborhood-Specific Crime Intervention
Creators: name: Robbins, Michael W.
name: Saunders, Jessica
name: Kilmer, Beau
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: The synthetic control method is an increasingly popular tool for analysis of program efficacy. Here, it is applied to a neighborhood-specific crime intervention in Roanoke, VA, and several novel contributions are made to the synthetic control toolkit. We examine high-dimensional data at a granular level (the treated area has several cases, a large number of untreated comparison cases, and multiple outcome measures). Calibration is used to develop weights that exactly match the synthetic control to the treated region across several outcomes and time periods. Further, we illustrate the importance of adjusting the estimated effect of treatment for the design effect implicit within the weights. A permutation procedure is proposed wherein countless placebo areas can be constructed, enabling estimation of p-values under a robust set of assumptions. An omnibus statistic is introduced that is used to jointly test for the presence of an intervention effect across multiple outcomes and post-intervention time periods. Analyses indicate that the Roanoke crime intervention did decrease crime levels, but the estimated effect of the intervention is not as statistically significant as it would have been had less rigorous approaches been used. Supplementary materials for this article are available online.
title: 18 - Entretien avec le vieil azmari Mulu’aläm Adägä : chant ambasäl
Creators: name: Wion, Anaïs
name: Bolay, Anne
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: chant

description: Chant ambasäl
Declaration of Helsinki's missed opportunity for healthy volunteer trials
Creators: name: Mwale, Shadreck
name: Fisher, Jill A
name: Hirsch, François
name: Bompart, François
name: Kurundkar, Sucheta Banerjee
Publisher: name: Elsevier
Year: 2024

description:
For the first time since 1964, the revised Declaration of Helsinki
provides an ethical framework for medical research and explicitly states that its provisions apply to all research participants, “whether patients or healthy volunteers."
A framework for synthetic control methods with high-dimensional, micro-level data: Evaluating a neighborhood-specific crime intervention
Creators: name: Robbins, Michael W.
name: Saunders, Jessica
name: Kilmer, Beau
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: The synthetic control method is an increasingly popular tool for analysis of program efficacy. Here, it is applied to a neighborhood-specific crime intervention in Roanoke, VA, and several novel contributions are made to the synthetic control toolkit. We examine high-dimensional data at a granular level (the treated area has several cases, a large number of untreated comparison cases, and multiple outcome measures). Calibration is used to develop weights that exactly match the synthetic control to the treated region across several outcomes and time periods. Further, we illustrate the importance of adjusting the estimated effect of treatment for the design effect implicit within the weights. A permutation procedure is proposed wherein countless placebo areas can be constructed, enabling estimation of p-values under a robust set of assumptions. An omnibus statistic is introduced that is used to jointly test for the presence of an intervention effect across multiple outcomes and post-intervention time periods. Analyses indicate that the Roanoke crime intervention did decrease crime levels, but the estimated effect of the intervention is not as statistically significant as it would have been had less rigorous approaches been used. Supplementary materials for this article are available online.
Effective benchmarking of high-density MEA spike-sorters
Creators: name: Diggelmann, Roland
name: Hierlemann, Andreas
name: Franke, Felix
Publisher: name: ETH Zurich
Year: 2018
Subjects: Spike-sorting
high-density MEAs
Benchmarking
Ground-truth
Retinal Ganglion Cells

description: Frontiers in Cellular Neuroscience
description: ISSN:1662-5102
description: Conference Abstract: MEA Meeting 2018 | 11th International Meeting on Substrate Integrated Microelectrode Arrays
Automatic extraction of axonal arbor morphology applied to h-iPSC-derived neurons
Creators: name: Zorzi, Giulio
name: Obien, Marie E.J.
name: Fiscella, Michele
name: Leary, Noelle
name: Hierlemann, Andreas
Publisher: name: ETH Zurich
Year: 2018
Subjects: Induced pluripotent stem cells
human neural stem cells
Astrocytes
neuron function
Axon tracing
microelectrode array
CMOS-MEAs

description: Frontiers in Cellular Neuroscience
description: ISSN:1662-5102
description: Conference Abstract: MEA Meeting 2018 | 11th International Meeting on Substrate Integrated Microelectrode Arrays
A Framework for Synthetic Control Methods With High-Dimensional, Micro-Level Data: Evaluating a Neighborhood-Specific Crime Intervention
Creators: name: Robbins, Michael W.
name: Saunders, Jessica
name: Kilmer, Beau
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: The synthetic control method is an increasingly popular tool for analysis of program efficacy. Here, it is applied to a neighborhood-specific crime intervention in Roanoke, VA, and several novel contributions are made to the synthetic control toolkit. We examine high-dimensional data at a granular level (the treated area has several cases, a large number of untreated comparison cases, and multiple outcome measures). Calibration is used to develop weights that exactly match the synthetic control to the treated region across several outcomes and time periods. Further, we illustrate the importance of adjusting the estimated effect of treatment for the design effect implicit within the weights. A permutation procedure is proposed wherein countless placebo areas can be constructed, enabling estimation of p-values under a robust set of assumptions. An omnibus statistic is introduced that is used to jointly test for the presence of an intervention effect across multiple outcomes and post-intervention time periods. Analyses indicate that the Roanoke crime intervention did decrease crime levels, but the estimated effect of the intervention is not as statistically significant as it would have been had less rigorous approaches been used. Supplementary materials for this article are available online.
Pre-whitening as a means to improve dimensionality reduction and simplify clustering in spike-sorters for multi-electrode recordings
Creators: name: Diggelmann, Roland
name: Fiscella, Michele
name: Hierlemann, Andreas
name: Franke, Felix
Publisher: name: ETH Zurich
Year: 2017

description: 26th Annual Computational Neuroscience Meeting (CNS*2017): Part 2
Comparison of axonal-conduction velocity in developing primary cells and human iPSC-derived neurons
Creators: name: Obien, Marie E.J.
name: Zorzi, Giulio
name: Fiscella, Michele
name: Leary, Noelle
name: Hierlemann, Andreas
Publisher: name: ETH Zurich
Year: 2018
Subjects: Axons
h-iPSC
axonal conduction speed
cell culture
Multielectrode array (MEA)
CMOS-MEAs
neuronal development

description: Poster Presentation & Abstract
description: Frontiers in Cellular Neuroscience
description: ISSN:1662-5102
description: Conference Abstract: MEA Meeting 2018 | 11th International Meeting on Substrate Integrated Microelectrode Arrays
Dual-mode Microelectrode Array with 20k-electrodes and High SNR for High-Throughput Extracellular Recording and Stimulation
Creators: name: Yuan, Xinyue
name: Hierlemann, Andreas
name: Frey, Urs
Publisher: name: ETH Zurich
Year: 2018
Subjects: CMOS MEA
Active-pixel sensor
switch matrix
extracellular recording
Stimulation

description: Frontiers in Cellular Neuroscience
description: ISSN:1662-5102
description: Conference Abstract: MEA Meeting 2018 | 11th International Meeting on Substrate Integrated Microelectrode Arrays
Peginterferon beta-1a versus other self-injectable disease-modifying therapies in the treatment of relapsing-remitting multiple sclerosis in Scotland: a cost-effectiveness analysis
Creators: name: Hernandez, Luis
name: Shien Guo
name: Toro-Diaz, Hector
name: Carroll, Stuart
name: Farooq, Syed Feisal Syed
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: Aims: Peginterferon beta-1a 125 mcg administered subcutaneously every 2 weeks, a new disease-modifying therapy (DMT) for relapsing-remitting multiple sclerosis (RRMS), was approved in January 2015 by the Scottish Medicines Consortium. This study assesses long-term clinical and economic outcomes of peginterferon beta-1a compared with other self-injectable DMTs (interferon beta-1a [22 mcg, 30 mcg, and 44 mcg], interferon beta-1b, and glatiramer acetate 20 mg) in the treatment of RRMS, from the National Health Service and Personal Social Services perspective in Scotland. Methods: A previously published, validated Markov cohort model was adapted for this analysis. The model estimates changes in patient disability, occurrence of relapses, and other adverse events, and translates them into quality-adjusted life years and costs. Natural history data came from the ADVANCE trial of peginterferon beta-1a, the London Ontario (Canada) database, and a large population-based MS survey in the UK. The comparative efficacy of each DMT vs placebo was obtained from a network meta-analysis. Costs (2015 British Pounds) were obtained from public databases and literature. Clinical and economic outcomes were projected over 30 years and discounted at 3.5% per year. Results: Over 30 years, peginterferon beta-1a was dominant compared with interferon beta-1a (22, 30, and 44 mcg), and interferon beta-1b, and cost-effective compared with glatiramer acetate 20 mg. Results were most sensitive to variations in each DMT’s efficacy and acquisition costs. Deterministic and probabilistic sensitivity analyses confirmed the robustness of the results. Limitations: The impact of improved adherence with peginterferon beta-1a on clinical and economic outcomes and the impact of subsequent DMTs after treatment discontinuation were not considered. Oral and infused DMTs were not included as comparators. Conclusion Long-term treatment with peginterferon beta-1a improves clinical outcomes, while its cost profile makes it either dominant or cost-effective compared with other self-injectable DMTs for the treatment of RRMS in Scotland.
Geology of the Northern Simbruini Mts. (Abruzzo – Italy)
Creators: name: Fabbi, Simone
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: This paper presents the results of a geological mapping project across the northern portion of the Simbruini Mts. (Latium-Abruzzi Domain – Central Apennines), where a thick Cretaceous and Miocene carbonate succession, followed by a thick upper Miocene terrigenous foredeep succession, is exposed. The terrigenous succession also includes a peculiar lithoclastic unit (‘brecce della Renga fm.’), whose sedimentation is linked to pre-orogenic (Tortonian-Messinian) extensional tectonics. The study area experienced late Messinian-early Pliocene compression, which is the Apennine chain building phase, followed by Quaternary post-orogenic extension, related to the opening of the Tyrrhenian basin. A geological map, at 1:20,000 scale, illustrates the main stratigraphic and structural features of the area.
Electrophysiological phenotype characterization of human iPSC-derived dopaminergic neuronal lines by means of high-resolution microelelectrode arrays
Creators: name: Fiscella, Michele
name: Leary, Noelle
name: Acun, Ebru
name: Ronchi, Silvia
name: Hierlemann, Andreas
Publisher: name: ETH Zurich
Year: 2018
Subjects: CMOS-MEAs
IPSC-derived neurons
Parkinson Disease
Microelectrode arrays
phenotyping

description: Frontiers in Cellular Neuroscience
description: ISSN:1662-5102
description: Conference Abstract: MEA Meeting 2018 | 11th International Meeting on Substrate Integrated Microelectrode Arrays
title: Where next for manufacturing productivity research? : Propositions based on exploratory empirical investigation
Creators: name: Clegg, Ben
name: MacBryde, Jill
name: Ball, Peter
name: Masi, Donato
name: Mullen, Helen
name: Despoudi, Stella
Publisher: name: Strathprints - University of Strathclyde
Year: 2024

description: Purpose The purpose of this research is to develop empirically grounded propositions for further research into UK manufacturing productivity. Design/methodology/approach Interviews were conducted with managers from strategic, tactical and operational levels from four manufacturing sectors to produce case studies. A modified strategic alignment theory framework was used to code, compare and contrast narratives on perceived productivity antecedents, definitions, compatibility with the definition from the UK Office for National Statistics, and vertical alignment issues within and across cases. Findings It was found that different key antecedents can facilitate and/or prevent strategic vertical alignment. Discussion reveals complex nuances in perceptions of manufacturing productivity and using the modified strategic alignment theory/productivity antecedent framework. Originality/value In revealing the alignment or otherwise of productivity definitions at different levels within the firm, the paper reveals nine propositions for future research including definitions, skills, metrics, performance measurement systems, people and system-centric perspectives, the value-added perspective of productivity and the role of innovation.
The Work of the Imagination: We Must Imagine the Future to Survive
Creators: name: Doble, Rick
Publisher: name: figshare
Year: 2016
Subjects: subject: 120301 Design History and Theory
subject: FOS: Arts (arts, history of arts, performing arts, music)
subject: 49999 Earth Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 40104 Climate Change Processes
subject: 40105 Climatology (excl. Climate Change Processes)
subject: 100701 Environmental Nanotechnology
subject: FOS: Nanotechnology

description: The Work of the Imagination: A Crisis of Imagination, We Must Imagine the Future to Survive.William Blake wrote, "What is now proved was once only imagined." This paper examines works of the imagination in the past that have led to ideas and technology of today. It also explores what will be needed to imagine and then create the technology of the future which will deal with the effects of human civilization on climate change and the environment.
Probing synaptic connectivity and function using high-density microelectrode arrays and whole-cell patch-clamp recordings
Creators: name: Bartram, Julian
name: Schröter, Manuel
name: Ronchi, Silvia
name: Emmenegger, Vishalini
name: Müller, Jan
name: Hierlemann, Andreas
Publisher: name: ETH Zurich
Year: 2019
Subjects: neural networks
synaptic plasticity
synaptic scaling
connectivity
network homeostasis

description: Conference Abstract: MEA Meeting 2018 | 11th International Meeting on Substrate Integrated Microelectrode Arrays
Mapping neuronal network dynamics in developing cerebral organoids
Creators: name: Schröter, Manuel
name: Girr, Monika
name: Boos, Julia
name: Renner, Magdalena
name: Gazorpak, Mahshid
name: Gong, Wei
name: Bartram, Julian
name: Müller, Jan
name: Hierlemann, Andreas
Publisher: name: ETH Zurich
Year: 2019
Subjects: Organoid
Cerebral cortex
Neurogenesis
spontaneous activity
connectivity mapping

description: Conference Abstract: MEA Meeting 2018 | 11th International Meeting on Substrate Integrated Microelectrode Arrays
Polyoxidovanadate complexes: synthesis, structures and catalytic oxidative bromination of phenol red
Creators: name: Lin, Xiao-Meng
name: Feng, Xiao-Dong
name: Wang, Yang
name: Xing, Yong-Heng
name: Sun, Li-Xian
name: Si-Yue Wei
name: Shi, Zhan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: By selecting appropriate ligands, two polyoxidovanadate complexes, [Ni(en)2]3[V18O42Cl]·7H2O·2H3O+ (1) and [H2N(CH3)2]3[PV14O42]·2TMP·6H3O+ (2), have been synthesized at different pH values using V2(SO4)3, Ni(CH3COO)2, and H6TTHA (for 1), VO(acac)2 and TPP (for 2) (en = C2H8N2, TPP = thiamine pyrophosphate, TMP = thiamine monophosphate, H6TTHA = 1,3,5-triazine-2,4,6-triamine hexaacetic acid). The complexes have been characterized by elemental analysis, IR spectroscopy, thermogravimetric analysis (TG), and single crystal X-ray diffraction. The complexes catalyze the oxidation of the organic substrate phenol red in the presence of H2O2 and bromide, and the reaction system is considered as a model for hydrogen peroxide determination. The reaction rate constants (k) for 1 and 2 are calculated as 3.729 × 103 and 4.083 × 103 (mol L)−2 s−1. The maximum conversion rate of phenol red for 1 is 83.32%, while for 2 is 81.12%.
MPEC 2024-K98 : 2017 MM
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
title: 01 – Entretien avec l’azmari Andargé Täfära : chant šäläla
Creators: name: Wion, Anaïs
name: Bolay, Anne
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: chant

description: Chant šäläla