cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Experimental study of collapse mechanisms in gravelly soils
Creators: name: Elhusain, Luai
Publisher: name: Imperial College London
Year: 2022

description: Unusual collapsible gravelly soils from Khartoum, Sudan, have led to severe structural damage, usually caused by water infiltration into the underlying ground. As taking undisturbed block samples of the natural soil was not possible because of its friable gravelly nature, analogue specimens were prepared from lightweight aggregate (Lytag) bonded with kaolin. Results from previous studies did not predict degrees of ‘collapse potential’ (CP) levels that correspond to the severe damage observed. A theoretical procedure is developed, based on differences between in-situ soil density and the maximum compacted density, which resulted in a more realistic magnitudes of CP (ratio of collapse settlement to layer thickness). The primary research focus involved an experimental programme, developed in three stages using analogue specimens. First, the effectiveness of conventional 1-D collapse tests was assessed. Second, larger diameter analogue specimens were tested under different boundary conditions with (a)full and (b)partial lateral confinement (similar to footing tests). The latter tests produced far more realistic collapse (10x the 1-D tests, i.e., from moderate to severe CP). Consequently, the third approach was to test under triaxial conditions, with careful control of lateral and deviatoric stresses (close to those in situ), and allowing axial, volume and radial collapse strains to be determined. Test boundary conditions strongly govern the magnitude of CP and collapse mechanism. Two different collapse mechanisms were identified. At high deviatoric stresses and low confining stresses, when the specimen was inundated, there was radial dilation, while radial contraction occurred under low deviatoric stresses and high confining stresses. The severity of CP increases with inundation collapse stress. A relationship between collapse strain and resulting increased collapse density with inundation collapse stress is developed: at constant cell pressures, this relation has a unique curve which can be used to classify the collapse mechanisms; a soil collapse classification chart is proposed.
Improved pulse wave analysis for diagnosing and monitoring heart failure
Creators: name: Reavette, Ryan
Publisher: name: Imperial College London
Year: 2022

description: Heart failure is treatable, but in the United Kingdom, the one-, five- and ten-year mortality rates are 24.1, 54.5 and 75.5%, respectively. The poor prognosis reflects, in part, the lack of specific, simple and affordable diagnostic techniques: the disease is often advanced by the time a diagnosis is made. Moreover, 79% of UK heart failure diagnoses are made only after an emergency hospital admission despite 41% of patients visiting their GP in the preceding five years with at least one the main symptoms of heart failure – breathlessness, fatigue or ankle swelling. The survival rates following a diagnosis in primary care are, as expected, better than the average, but there are clear missed opportunities for early diagnosis and intervention. There is also a significant disconnect between clinical guidelines and actual patient diagnoses: between 2010–2013, only 24% of UK patients were diagnosed according to the pathway recommended by the European Society of Cardiology. All of these factors necessitate an improved diagnosis pipeline. Arterial waves carry information about the performance of the heart and vessels, and previous studies have demonstrated that certain metrics derived from pressure–velocity-based wave intensity analysis are significantly altered in the presence of heart failure. The pressure wave- form, however, can only be obtained accurately using invasive methods, which has inhibited clinical adoption. This thesis investigates the potential for a new form of wave intensity – based instead on noninvasive ultrasound measurements of arterial diameter and velocity – to improve the heart failure diagnosis pipeline. Diameter and pressure are intrinsically related, but this relationship is fundamentally nonlinear, as the arterial wall exhibits properties such as viscoelasticity and strain stiffening. Through one- 5 dimensional computational modelling of blood flow in a virtual population of 600 people, this thesis has shown the two forms of wave intensity are similar regardless of these nonlinearities. Using a second virtual population of 2000 people – with half modelled as healthy controls and half with heart failure through an impaired stroke volume – this thesis has also shown that, when analysed with machine learning-based classification techniques, metrics derived from this diameter-based wave intensity can identify heart failure in individual patients with 99% recall and 95% precision. Computational results must be corroborated with experimental findings before they can be truly accepted. This thesis also, therefore, describes a first-in-man trial where ultrafast ultrasound-based measurements of wave intensity were made in controls and heart failure patients. Statistically significant differences were identified in multiple wave intensity metrics representative of both systolic and diastolic function; the results are promising regarding the introduction of noninvasive wave intensity to the clinic.
[Grundriss der Burg Hohenklingen in Stein am Rhein]
Creators: name: Rahn, Johann Rudolf
name: Zeller-Werdmüller, Heinrich
Publisher: name: [s.n.]
Year: 1862
Subjects: Stein, Rhein

description: HZ ; JR [Monogramme]
description: JR = Johann Rudolf Rahn
description: HZ = vermutlich Heinrich Zeller-Werdmüller
Burden of foodborne disease: pilot study in Albania progress report
Creators: name: Molla, Lindita
name: Roshi, Enver
name: Lake, Robin
Publisher: name: Institute of Environmental Science and Research
Year: 2019
Subjects: Infectious diseases
Microbiology not elsewhere classified

description: In September 2006 the World Health Organization (WHO) Department of Food Safety and Zoonoses launched an initiative to estimate the global burden of foodborne diseases. Two of the three objectives of the initiative are to strengthen national capacity to conduct burden of foodborne illness studies and promote the use of results in policy. This paper describes progress on a national burden of foodborne illness study in Albania. Human health surveillance and food safety agencies in Albania are described as part of a situation analysis. Data from these agencies includes reported cases of gastro entericdisease, food poisoning but etiologyc data are few. Ad hoc studies of other potentially foodborne diseases (parasitic and viral infections) have been conducted, but the importance of foodborne transmission is unclear. Data on the prevalence of hazards (particularly chemicals) in the food supply are very limited. The global and regional estimates provided by the WHO initiative will help fill data gaps and provide context to assist estimation of the burden of foodborne disease in Albania.
Hohenklingen. Geschützblende im Thurm
Creators: name: Rahn, Johann Rudolf
Publisher: name: [s.n.]
Year: 1862
Subjects: Stein, Rhein

description: Dargestellt wird eine Geschützblende im Turm der Burg Hohenklingen in Stein am Rhein
description: J Rahn
description: Johann Rudolf Rahn hat handschriftlich mit roter Feder notiert "verte!"
Evidence of transmission of an NDM-5-producing Klebsiella pneumoniae in a healthcare facility in New Zealand
Creators: name: Howard, Julia C.
name: Creighton, Julie
name: Heffernan, Helen
name: Werno, Anja
Publisher: name: Institute of Environmental Science and Research
Year: 2019
Subjects: Clinical microbiology
Health care administration
Medical infection agents (incl. prions)
Epidemiology not elsewhere classified
Microbiology not elsewhere classified
Infectious diseases
Pharmacology and pharmaceutical sciences not elsewhere classified

description: Carbapenemase-producing Enterobacteriaceae (CPE) are still relatively rarely isolated in New Zealand (NZ). Between 2009 and 2014, only 35 confirmed, non-duplicate isolates were reported to the national CPE surveillance system. However, the prevalence is increasing, with 41 isolates reported in 2015. In NZ to date, the majority of patients with CPE have had a history of hospitalization or travel within countries with a high prevalence of CPE. However, for the first time in 2015, transmission of CPE in NZ healthcare facilities was identified.
Genome-wide DNA methylation analysis reveals loci that distinguish different types of adipose tissue in obese individuals
Creators: name: Macartney-Coxson, Donia
name: C. Benton, Miles
name: Blick, Ray
name: Stubbs, Richard S.
name: Hagan, Ronald D.
name: Langston, Michael A.
Publisher: name: Institute of Environmental Science and Research
Year: 2019
Subjects: Genomics
Genetics not elsewhere classified

description: Background: Epigenetic mechanisms provide an interface between environmental factors and the genome and are known to play a role in complex diseases such as obesity. These mechanisms, including DNA methylation, influence the regulation of development, differentiation and the establishment of cellular identity. Here we employ two approaches to identify differential methylation between two white adipose tissue depots in obese individuals before and after gastric bypass and significant weight loss. We analyse genome-wide DNA methylation data using (a) traditional paired t tests to identify significantly differentially methylated loci (Bonferroni-adjusted P≤1×10−7) and (b) novel combinatorial algorithms to identify loci that differentiate between tissue types.
Results: Significant differential methylation was observed for 3239 and 7722 CpG sites, including 784 and 1129 extended regions, between adipose tissue types before and after significant weight loss, respectively. The vast majority of these extended differentially methylated regions (702) were consistent across both time points and enriched for genes with a role in transcriptional regulation and/or development (e.g. homeobox genes). Other differentially methylated loci were only observed at one time point and thus potentially highlight genes important to adipose tissue dysfunction observed in obesity. Strong correlations (r>0.75, P≤0.001) were observed between changes in DNA methylation (subcutaneous adipose vs omentum) and changes in clinical trait, in particular for CpG sites within PITX2 and fasting glucose and four CpG sites within ISL2 and HDL. A single CpG site (cg00838040, ATP2C2) gave strong tissue separation, with validation in independent subcutaneous (n=681) and omental (n=33) adipose samples.
Conclusions: This is the first study to report a genome-wide DNA methylome comparison of subcutaneous abdominal and omental adipose before and after weight loss. The combinatorial approach we utilised is a powerful tool for the identification of methylation loci that strongly differentiate between these tissues. This study provides a solid basis for future research focused on the development of adipose tissue and its potential dysfunction in obesity, as well as the role DNA methylation plays in these processes.
Large-scale release of Campylobacter draft genomes: resources for food safety and public health from the 100K Pathogen Genome Project
Creators: name: Weis, Allison M.
name: Huang, Bihua C.
name: Storey, Dylan B.
name: Kong, Nguyet
name: Chen, Poyin
name: Narine Arabyan
name: Brent Gilpin
name: Carl Mason
name: Townsend, Andrea K.
name: Smith, Woutrina A.
name: Byrne, Barbara A.
name: Taff, Conor C.
name: Weimer, Bart C.
Publisher: name: Institute of Environmental Science and Research
Year: 2019
Subjects: Biochemistry and cell biology not elsewhere classified
Epigenetics (incl. genome methylation and epigenomics)
Genetics not elsewhere classified
Genomics
Infectious diseases
Microbiology not elsewhere classified

description: Campylobacter is a food-associated bacterium and a leading cause of foodborne illness worldwide, being associated with poultry in the food supply. This is the initial public release of 202 Campylobacter genome sequences as part of the 100K Pathogen Genome Project. These isolates represent global genomic diversity in the Campylobacter genus.
Hohenklingen. Geschützblende im Thurm
Creators: name: Rahn, Johann Rudolf
Publisher: name: [s.n.]
Year: 1862
Subjects: Stein, Rhein

description: Dargestellt wird eine Geschützblende im Turm der Burg Hohenklingen in Stein am Rhein
description: J Rahn
description: Johann Rudolf Rahn hat handschriftlich unterhalb der Bezeichnung die Masse der einzelnen Elemente notiert
Harnessing Tissue Engineering Approaches to Develop Advanced 3D Models for Respiratory Drug Development and Respiratory Regenerative Therapies
Creators: name: Soriano, Luis
Publisher: name: Royal College of Surgeons in Ireland
Year: 2022
Subjects: subject: 100404 Regenerative Medicine (incl. Stem Cells and Tissue Engineering)
subject: FOS: Medical biotechnology
subject: 110203 Respiratory Diseases
subject: FOS: Clinical medicine

description: Respiratory diseases and major airway trauma represent a global healthcare emergency with most treatment options providing symptomatic relief rather than curative treatment. In addition, they are associated with enormous socioeconomic burden. Respiratory tissue engineering commonly focuses on two broad areas: (i) the development of novel in vitro models for drug discovery and (ii) on artificial constructs for tissue repair and regeneration. The development of physiologically-representative tracheobronchial tissue analogues has the potential to improve the translation of novel inhaled therapies by accurately reflecting in vivo respiratory pharmacological and toxicological responses. On the other hand, effective restoration of extensive tracheal damage arising from cancer, stenosis, infection or congenital abnormalities remains an unmet clinical need in respiratory medicine. In this project, tissue-engineered (TE) collagen hyaluronic acid bilayered (CHyA-B) scaffolds were used to evaluate bacterial and drug induced toxicity and inflammation using Calu-3 bronchial epithelial cells and Wi38 lung fibroblast co-culture under air liquid interface (ALI) conditions as an in vitro model of the upper respiratory tract. After using lipopolysaccharide (LPS) and bleomycin to induce bacterial and drug responses in vitro; differential cell responses were seen between 2D and 3D airway models. Furthermore, the co-culture 3D model provided differential epithelial responses to a number of inhaled nanoparticles compared to 2D models. Based on our understanding of the cell-matrix interactions involved in supporting respiratory epithelial cell growth and differentiation, we sought to harness these CHyA-B scaffolds to develop tubular TE tracheal constructs. A 3Dprinted polymer mesh of thermoplastic polymers with tailored architecture was fabricated and characterised to provide the tubular backbone of the construct. Polyglobalide (PGL), an advanced synthetic polymer that allows for post-processing surface modifications in comparison to commonly used polymers such as polycaprolactone (PCL), was employed as a 3D printable material. This was then covered with CHyA-B scaffolds using a freeze-drying process and Calu-3 epithelial cells were seeded onto its luminal film surface resulting in the formation of a partial epithelial layer. 3D printed PCL- and PGL-CHyA tubular scaffolds are promising biocompatible prototypes for tracheal regeneration with adequate mechanical properties supporting epithelial growth.
Hohenklingen (nach H Zeller)
Creators: name: Rahn, Johann Rudolf
Publisher: name: [s.n.]
Year: 1862
Subjects: Stein, Rhein

description: Dargestellt wird ein Grundriss der Burg Hohenklingen in Stein am Rhein. Rahn orientiert sich bei seiner Zeichnung an einer Grundrissdarstellung von Heinrich Zeller-Werdmüller
description: [Johann Rudolf Rahn]
description: Johann Rudolf Rahn hat handschriftlich die einzelnen Elemente teilweise beschriftet und mit Längenangaben oder Grossbuchstaben versehen. Die Buchstaben löst Rahn in einer Legende unterhalb der Darstellung auf
Tree-based models and cell fate choice
Creators: name: Croydon Veleslavov, Ivan Alexander
Publisher: name: Imperial College London
Year: 2021

description: Lineage analysis is concerned with how pluripotent progenitors divide and differentiate to form the myriad of mature cell types we observe in complex organisms. During differentiation, these cells respond to complex spatiotemporal signals that impact cell fate choice. Small, quantitative changes in the expression of key genes can result in sister cells whose dynamics and cell fates are qualitatively distinct. With advances in single-cell transcriptomics, we can now observe in unprecedented detail how heterogeneity in gene expression between cells in a population can give rise to specialised cell populations during development. Models that allow us to interrogate these transcriptomic differences and relate the outcomes of cell fate choice to genetic drivers carry clear appeal. Suitable models would allow us to predict cell classes from transcriptomic data alone, give probabilistic estimates for cell fates in branching trajectories and even predict how a system might behave under perturbation. In this thesis we present a series of tree-based models trained on single-cell gene expression data to predict cell classes. Using Murine neural differentiation and Xenopus tropicalis embryogenesis as two diverse developmental settings, we show that these models perform well on withheld data and that their structure confers opportunities for knowledge discovery. Focusing on their capability for embedded feature selection, we demonstrate that these tree-based methods robustly identify features involved in regulating the cell fate boundaries of interest. The analysis provided in this thesis considers the tension between model complexity and predictive performance. We motivate these variously complex tree-based models, working up from shallow decision stumps through to fully Bayesian ensembles. In the final case, we propose a means of incorporating prior information into Bayesian additive regression tree models through a sparsity-inducing, asymmetric Dirichlet hyperprior. We show that appropriate prior information can both improve model performance and reduce the complexity of the learnt ensemble.
Modelling and design of shear wave EMATs
Creators: name: Parra Raad, Jaime Alberto
Publisher: name: Imperial College London
Year: 2022

description: In this thesis two physical phenomena were investigated: the mechanical load generation and wavefield radiation of Electro-Magnetic Acoustic Transducers (EMATs). The conceptual results obtained in this work addressed two major research questions: how the transduction of EMATs and the properties of materials affect the EMAT's wavefield generation, and how orthogonal shear waves can be used to detect and characterise surface-breaking defects. The outcome of these two research questions were tested in the design of an orthogonal and co-located coils shear wave EMAT and in the design of a shear wave phased array EMAT. EMATs, are transducers that by means of electromagnetic forces excite mechanical loads in metallic materials. EMATs are often utilised in the Non-Destructive Evaluation, NDE, of a material to detect and characterise the material anomalies. Compared to their counterpart, Piezoelectric transducers, EMATs have several properties that make them a desirable means of transduction for NDE applications. EMATs are contactless and special designs can tolerate high temperatures. Hence, EMATs do not require direct contact with the inspected material to perform the NDE inspection nor cooling system to keep them operational during a NDE procedure. Nevertheless, the use of EMATs in NDE inspections is not standard procedure in industry. This is because there are concerns over the strength and orientation of the mechanical loads that EMATs produce, and the lack of knowledge about the effects that the magnetic properties of the inspected material have on the wavefield generated with EMATs. To address these concerns, the excitation mechanisms of EMAT transduction were studied on different metallic materials. The three excitation mechanisms -the Lorentz force, the magnetisation force and the magnetostriction force- of a shear wave phased-array EMAT were estimated on paramagnetic, diamagnetic, ferromagnetic and magnetostrictive materials. The results obtained showed that by designing an EMAT to maximise the Lorentz Force mechanism, an EMAT can maximise the strength of the mechanical loads it excites and yield a consistent wavefield in the inspected material. The interaction of orthogonal and co-located shear waves with surface-breaking defects was also studied in this thesis. The study focused on the detection and characterisation of surface-breaking defects in isotropic and anisotropic materials. To execute the mentioned analysis, the design of an EMAT that can simultaneously excite two co-located shear waves with orthogonal polarisation was proposed. Once the wave interaction with the defects was understood, a methodology that by means of the two shear waves can gauge the inspected material, detect the presence of a defect, characterise the principal shear direction of the inspected material and characterise the height of the surface-breaking defect was presented.
Auf Hohenklingen. Thurm i 2 obersten Geschosse
Creators: name: Rahn, Johann Rudolf
Publisher: name: [s.n.]
Year: 1862
Subjects: Stein, Rhein

description: Dargestellt wird eine Fensternische im zweiten Turmgeschoss der Burg Hohenklingen in Stein am Rhein
description: [Johann Rudolf Rahn]
Hohenklingen. Thurm i 3. obersten Geschosse
Creators: name: Rahn, Johann Rudolf
Publisher: name: [s.n.]
Year: 1862
Subjects: Stein, Rhein

description: Dargestellt wird eine Fensternische im dritten Turmgeschoss der Burg Hohenklingen in Stein am Rhein
description: [Johann Rudolf Rahn]
description: Johann Rudolf Rahn hat handschriftlich notiert "Mauerdicke 6'" sowie "[...] Quader 3' Tiefe [...] 3 [2...] Breite"
Isolation of seven distinct carbapenemase-producing Gram-negative organisms from a single patient
Creators: name: Creighton, Julie
name: Heffernan, Helen
name: Howard, Julia
Publisher: name: Institute of Environmental Science and Research
Year: 2019
Subjects: Clinical microbiology
Epidemiology not elsewhere classified
Medical bacteriology

description: Carbapenemase-producing organisms (CPO) continue to spread around the globe at an alarming rate. People travelling to, and especially hospitalized in, areas that have high prevalence rates of MDR organisms (MDRO), such as ESBL- and carbapenemase producing Gram-negative organisms, are at risk of acquiring these bacteria and subsequent colonization or infection. In low-prevalence countries, such as New Zealand (NZ), this risk factor has recently been identified for the first cases of Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae reported in NZ. Current reports of CPO in NZ are rare, with a low number of patients found to have cocarriage of more than two CPO and coproducing strains infrequently encountered. Here, we report the isolation of seven distinct CPO, together with an ESBL-producing Pseudomonas aeruginosa and Proteus mirabilis with an ACC-type AmpC b-lactamase, from a patient recently returned to NZ from a Romanian hospital.
Kanone auf Hohenklingen i obersten Geschosse
Creators: name: Rahn, Johann Rudolf
Publisher: name: [s.n.]
Year: 1862
Subjects: Stein, Rhein

description: Dargestellt wird eine Kanone, die sich im obersten Turmgeschoss der Burg Hohenklingen in Stein am Rhein befindet
description: [Johann Rudolf Rahn]
description: Johann Rudolf Rahn hat handschriftlich notiert "Kaliber 2"". Weiter hat Johann Rudolf Rahn teilweise die Längenangaben der Kanone notiert
The presence and impact of psychological safety and stress in the NHS workforce - a mixed methods exploration of the workplace environment
Creators: name: Grailey, Katherine Elizabeth
Publisher: name: Imperial College London
Year: 2022

description: The National Health Service faces many challenges including the preservation of a healthy workforce and prevention of medical error. Psychological Safety, defined as an environment “safe for interpersonal risk taking” can help mitigate these challenges. This environment, where individuals feel safe to “speak up” can promote organisational safety and individual wellbeing. “Stress” is also implicated in the aetiology of error and low job satisfaction, justifying strategies to minimise its occurrence. This Thesis aims to describe key and previously undescribed features regarding the manifestation of psychological safety and stress in healthcare workers. Existing data regarding psychological safety were explored through a comprehensive evidence synthesis. Three mixed methods studies encompassing qualitative interviews and quantitative surveys were subsequently conducted. These explored the aetiology, presence, impact and sequelae of psychological safety and stress in critical care workers, emergency department staff and hospital managers. Data provided a detailed understanding of the complexity of the workplace environment from an individual worker’s perspective. A reassuring climate of psychological safety was demonstrated in clinical participants. This was lower for managers, highlighting how this environment can differ within the same organisation. Data analyses yielded novel information regarding the influence of situational context and personality on psychological safety and demonstrated the potential for negative consequences of such an environment. Both ‘typical’ stressors and the COVID-19 pandemic were evaluated, highlighting that whilst generally detrimental, challenging events could create positive sequelae including enhanced camaraderie. Models were developed highlighting key factors within the workplace that can be improved to enhance psychological safety and mitigate stress. It is important for staff wellbeing and organisational safety that a climate of psychological safety is cultivated, and that stresses are mitigated and supported. Healthcare leaders can use the models presented in this Thesis to identify modifiable areas for change and implement solutions within their own workplace environments.
Tracking effluent discharges in undisturbed stony soil and alluvial gravel aquifer using synthetic DNA tracers
Creators: name: Pang, Liping
name: Robson, Beth
name: Farkas, Kata
name: McGill, Erin
name: Varsani, Arvind
name: Gillot, Lea
name: Li, Jinhua
name: Abraham, Phillip
Publisher: name: Institute of Environmental Science and Research
Year: 2019
Subjects: Environmental assessment and monitoring
Soil biology
Soil chemistry and soil carbon sequestration (excl. carbon sequestration science)
Natural resource management
Environmental management

description: With the intensification of human activities, fresh water resources are increasingly being exposed to contamination from effluent disposal to land. Thus, there is a greater need to identify the sources and pathways of water contamination to enable the development of better mitigation strategies. To track discharges of domestic effluent into soil and groundwater, 10 synthetic double-stranded DNA (dsDNA) tracers were developed in this study. Laboratory column experiment and field groundwater and soil lysimeter studies were carried out spiking DNA with oxidation-pond domestic effluent. The selected DNA tracers were compared with a non-reactive bromide (Br) tracer with respect to their relative mass recoveries, speeds of travel and dispersions using the method of temporal moments. In intact stony soil and gravel aquifer media, the dsDNA tracers typically showed earlier breakthrough and less dispersion than the Br tracer, and underwent mass reduction. This suggests that the dsDNA tracers were predominantly transported through the network of larger pores or preferential flow paths. Effluent tracking experiments in soil and groundwater demonstrated that the dsDNA tracers were readily detectable in effluent-contaminated soil and groundwater using quantitative polymerase chain reaction. DNA tracer spiked in the effluent at quantities of 36 μg was detected in groundwater 37 m down-gradient at a concentration 3-orders of magnitude above the detection limit. It is anticipated it could be detected at far greater distances. Our findings suggest that synthetic dsDNA tracers are promising for tracking effluent discharges in soils and groundwater but further studies are needed to investigate DNA-effluent interaction and the impact of subsurface environmental conditions on DNA attenuation. With further validation, synthetic dsDNA tracers, especially when multiple DNA tracers are used concurrently, can be an effective new tool to track effluent discharge in soils and groundwater, providing spatial estimation on the presence or absence of contamination sources and pathways.
A 1-year study on the detection of human enteric viruses in New Caledonia
Creators: name: Kaas, Laetitia
name: Gourinat, Ann-Claire
name: Urbès, Florence
name: Langlet, Jérémie
Publisher: name: Institute of Environmental Science and Research
Year: 2019
Subjects: Microbial genetics
Microbiology not elsewhere classified
Microbial ecology

description: Human enteric viruses occur in high concentrations in wastewater and can contaminate receiving environmental waters. Due to the lack of data on the prevalence of enteric viruses in New Caledonia, the presence and the concentrations of enteric viruses in wastewater and seawater were determined. Untreated wastewater and seawater samples were collected monthly for 1 year from a wastewater treatment plant (WWTP) and from the WWTP’s outlet, located directly on a popular recreational beach. Samples were tested for norovirus genogroups I and II (NoV GI and GII), rusesastrovi (AsV), sapoviruses (SaV), enteroviruses (EV), hepatitis A viruses (HAV), rotaviruses (RoV), human adenoviruses (HAdV) and human polyomaviruses (HPyV). To support these data, faecal samples from cases of gastroenteritis were tested for the first time for NoV and detected in the population. NoV GI, NoV GII, EV, SaV, HAdV and HPyV were detected in all wastewaters, RoV in 75 % and AsV in 67 %. HAV were not detected in wastewater. Overall, 92 % of seawater samples were positive for at least one virus. HPyV were detected most frequently in 92 % of samples and at concentrations up to 7.7 × 103 genome copies/L. NoV GI, NoV GII, EV, SaV, RoV and HAdV were found in 33, 66, 41, 33, 16 and 66 % of seawater samples, respectively. AsV were not detected in seawater. This study reports for the first time the presence of NoV and other enteric viruses in New Caledonia and highlights the year-round presence of enteric viruses in the seawater of a popular beach.
Auf Hohenklingen. Schlosskapelle
Creators: name: Rahn, Johann Rudolf
Publisher: name: [s.n.]
Year: 1862
Subjects: Stein, Rhein

description: Dargestellt wird eine Aussenansicht der Kapelle auf der Burg Hohenklingen in Stein am Rhein, von Süden aus gesehen
description: [Johann Rudolf Rahn]
Schloss Hohenklingen. Thurm. Mauer am Fundamente
Creators: name: Rahn, Johann Rudolf
Publisher: name: [s.n.]
Year: 1862
Subjects: Stein, Rhein

description: Dargestellt wird ein Ausschnitt der Fundamentsmauer der Burg Hohenklingen in Stein am Rhein
description: [Johann Rudolf Rahn]
Activity concentrations of (137)Caesium and (210)Polonium in seafood from fishing regions of New Zealand and the dose assessment for seafood consumers
Creators: name: Pearson, Andrew J.
name: Gaw, Sally
name: Hermanspahn, Nikolaus
name: Glover, Chris N.
Publisher: name: Institute of Environmental Science and Research
Year: 2019
Subjects: Animal physiology - systems
Animal physiology - cell
Cell metabolism
Marine and estuarine ecology (incl. marine ichthyology)
Animal physiology - biophysics

description: A study was undertaken to determine activity concentrations for (134)Caesium, (137)Caesium and (210)Polonium in New Zealand seafood, and establish if activity concentrations varied with respect to species/ecological niche and coastal region. Thirty seafood samples were obtained from six fishing regions of New Zealand along with a further six samples of two commercially important species (hoki and arrow squid) with well-defined fisheries. (134)Caesium was not detected in any sample. (137)Caesium was detected in 47% of samples, predominantly in pelagic fish species, with most activities at a trace level. Detections of (137)Caesium were evenly distributed across all regions. Activity concentrations were consistent with those expected from the oceanic inventory representing residual fallout from global nuclear testing. (210) Polonium was detected above the minimum detectable concentration in 33 (92%) of the analysed samples. Molluscs displayed significantly elevated activity concentrations relative to all other species groups. No significant regional variation in activity concentrations were determined. Two dose assessment models for high seafood consumers were undertaken. Dose contribution from (137)Caesium was minimal and far below the dose exemption limit of 1 mSv/year. Exposure to (210)Polonium was significant in high seafood consumers at 0.44-0.77 mSv/year (5th-95th percentile). (137)Caesium is concluded to be a valuable sentinel radionuclide for monitoring anthropogenic releases, such as global fallout and reactor releases, in the marine environment. (210)Polonium is of importance as a natural radionuclide sentinel due to its high contribution to dietary committed dose in seafood consumers.
Macroteleia bicolora Kieffer 1908
Creators: name: Notton, David G.
name: Popovici, Ovidiu A.
name: Achterberg, Cornelis Van
name: Rond, Jeroen De
name: Burn, John T.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Scelionidae
Macroteleia
Macroteleia bicolora

description: Macroteleia bicolora Kieffer, 1908
Figs 7–9
Identification
This specimen was identified to genus using the key by Masner (1980) but it did not agree with either of the two previously known British species of Macroteleia (Notton, 2006). The identity of the species was confirmed by the second author, who has examined the type and compared it to published descriptions (Kieffer 1908, 1914, 1926; Kozlov 1987; Kononova & Kozlov 2008). Johnson (1992) catalogued numerous Palaearctic species of this genus and more have been described since (Kozlov & Kononova 1987, 1990; Kononova & Petrov 2003), although many of the older species have not been reinterpreted recently, and it is possible that the name M. bicolora will turn out to be a synonym.
Material examined
ENGLAND: Hants, Botley Wood, SU 5409, ♀, 31 Jul. 2007, Malaise trap, K. J. Wheeler (BMNH).
Distribution
This species was originally described from Italy by Kieffer (1908), and its distribution includes: Northern Italy, Kazakhstan, Russia (Northern Caucasus), Ukraine (Kononova & Kozlov 2008) and Denmark (Buhl 1999). It is recorded here as new to Britain.
Biology
The biology of this species is poorly known; however, the habitat at the Botley Wood Local Nature Reserve and SSSI is an extensive area of varied woodland, scrub and grassland with rides and ancient droveways of high conservation significance for invertebrates managed by Hampshire County Council/ Natural England.
description: Published as part of Notton, David G., Popovici, Ovidiu A., Achterberg, Cornelis Van, Rond, Jeroen De & Burn, John T., 2014, Parasitoid wasps new to Britain (Hymenoptera: Platygastridae, Eurytomidae, Braconidae & Bethylidae), pp. 1-20 in European Journal of Taxonomy 99 (99) on page 7, DOI: 10.5852/ejt.2014.99, http://zenodo.org/record/3838972
Understanding The Tumour Microenvironment Of Neuroblastoma By Modelling Stromal Schwann Cell Interaction And 3D In Vitro Culturing.
Creators: name: Coll, Erin
Publisher: name: Royal College of Surgeons in Ireland
Year: 2022
Subjects: subject: 60802 Animal Cell and Molecular Biology
subject: FOS: Biological sciences
subject: Cancer
subject: Cell Biology

description: Neuroblastoma (NB) is an aggressive paediatric cancer that affects the sympathetic nervous system. Current therapies are ineffective long term for 80% of patients with clinically aggressive, high-risk disease. The major barriers in developing effective treatments against high-risk NB include the lack of preclinical models and insufficient knowledge of cell communication within the tumour microenvironment (TME) of NB. With this in mind, the aims of this work include:1) Generate 3D in vitro neuroblastoma spheroids for therapeutic screening of platinum-based chemotherapeutics.2) Investigate the Schwann cell-neuroblastoma interaction.In chapter one, Spheroicalplate5D (SP5D) was used to generated spheroids to study the phenotypes of NB cell lines in three dimensional (3D) culture. All tested seeding densities formed large, uniform clusters after 4-5 days in culture. Spheroids generated using MYCN amplified Kelly cells did not display a more aggressive phenotype compared to non-MYCN amplified SH-SY5Y spheroids. In contrast, spheroids generated using cisplatin resistant KellyCis83 cells displayed an increased metabolism and aggressive phenotype compared to the cisplatin sensitive Kelly cells. The novel fluorophore conjugated compound (Pt(tet)(DMSO)(Cl)2) demonstrated comparable IC50 values in two dimensional (2D) culture to standard chemotherapies. 3D NB spheroids demonstrated reduced sensitivity to the novel platinum-based chemotherapy compared to 2D culture.In chapter two, the direct and paracrine cell communication between neuroblasts and stromal Schwann cells (SCs) was investigated using co-culture and Schwann cell- derived exosomes (SC-EVs). It was found that direct contact between SCs and neuroblasts led to increased single-cell dispersion of neuroblasts. Whereas SC-EVs reduced the proliferation, migration, and invasion of NB by inducing a differentiated phenotype in NB cells. Ultimately, uniform and reproducible NB spheroids were generated and optimised for therapeutic screening. While the data is preliminary, an important interaction between neuroblast and SCs in the TME of NB was highlighted.
IIlens. Flüchtige Skizze
Creators: name: Rahn, Johann Rudolf
Publisher: name: [s.n.]
Year: 1892
Subjects: Rossens

description: Dargestellt wird der Grundriss des ehemaligen Schlosses von Guillaume de La Baume in Illens/Rossens
description: [Johann Rudolf Rahn]
description: Johann Rudolf Rahn hat die einzelnen Elemente handschriftlich beschriftet "Saane", "Au", "ca 100 Schritt" und "Weg nach den Granges d'Illens"
IIlens. Abtritte
Creators: name: Rahn, Johann Rudolf
Publisher: name: [s.n.]
Year: 1892
Subjects: Rossens

description: Dargestellt wird eine Mauer, ergänzt mit einem Abtritt, des ehemaligen Schlosses von Guillaume de La Baume in Illens/Rossens
description: [Johann Rudolf Rahn]
description: Handschrifttliche Notiz von Johann Rudolf Rahn "2e (s.v. Südliche Reihe) von unten i Abtritt F Himmel"
Identification of Leishmania tropica and Leishmania aethiopica by DNA
      Sequencing and the Detection of Leishmania RNA Virus
Creators: name: Thomas, Megan
Publisher: name: Lancaster University
Year: 2018
Subjects: Leishmania
Leishmaniasis

description: Leishmaniasis is a neglected tropical disease and a major cause of
      morbidity and mortality in impoverished countries. Leishmaniasis is a
      global disease and is clinically and epidemiologically diverse, with many
      different species of Leishmania affecting humans. The aim of this study
      was to investigate the classification of L. tropica and L. aethiopica as
      different species, and to check for the presence of LRV in their isolates.
      L. tropica and L. aethiopica are closely related species of Leishmania
      that infect humans; and there is some debate over whether they are indeed
      different species. The Leishmania RNA Virus is a double stranded RNA virus
      which infects Leishmania and is thought to increase the pathology of the
      disease and exacerbating mucosal developments. The methods used in this
      study were polymerase chain reaction and sequencing for the ITS1 gene and
      a dot blot to detect the presence of LRV. The results of the PCR were used
      for identification, the formation of phylogenetic trees, and a distance
      pairwise matrix. The PCR results supported the classification of L.
      tropica and L. aethiopica as different species, supporting previous
      results also used for the analysis. The results of the dot blot found LRV
      presence in the L. aethiopica isolates but no evidence of the virus in L.
      tropica. The identification of an infecting species of Leishmania and the
      clinical outcomes it can cause will help provide appropriate and affective
      treatment. The findings of this study also demonstrate the importance of
      species identification and the methods used.
title: (Under)privileged bureaucrats? The changing fortunes of public servants in Kenya, Tanzania and Uganda, 1960–2010
Creators: name: Simson, Rebecca
Publisher: name: London School of Economics and Political Science (LSE)
Year: 2017
Subjects: subject: H Social Sciences
subject: HC Economic History and Conditions

description: At independence the emerging African elite was dominated by employees of the state. Many academics have since speculated that this over-reliance on public employment contributed to the continent’s poor economic performance, as resources extracted from society were captured by a rent-seeking public sector class. Because this elite was directly beholden to the state, it also lacked the independence needed to hold the political class to task. Was this diagnosis accurate and has the state’s role as a creator of the elite persisted? This dissertation explores how three East African governments –those of Kenya, Tanzania and Uganda - have used their powers as the single largest employer in their respective countries to influence the structure of society. Using quantitative evidence, it traces how public employment and pay evolved between the 1960s and the present. It examines the effects of these changes on the economic standing of public sector employees and the educational, regional and ethnic backgrounds of the people who came to work for the state. This long-run perspective shows that the public services in all three countries have changed a great deal over the past half-century and suggests that public sector salaries have declined in importance for the region’s educational and income elites. It also reveals that public sector jobs have been more evenly distributed - on a regional, ethnic and gender basis - than is sometimes presumed. The thesis relates these findings to a rich political economy literature on public employment, social stratification and the
 development of the African postcolonial state.
Chalet du XVIe siècle à Matten (Interlaken)
Creators: name: Rahn, Johann Rudolf
Publisher: name: [s.n.]
Year: 1860

description: Dargestellt wird ein Ausschnitt der Pforte eines Hauses an der Alten Unterdorfstrasse 5 in Matten bei Interlaken. Dieser Blockbau ist 1573 datiert und wurde 1983 restauriert
description: [Johann Rudolf Rahn]
description: Handschriftliche Notiz von Johann Rudolf Rahn "Tout près se trouve un autre grand chalet de 1594"
Kodierschema Für Die Assoziationen Der Stimulusbegriffe  "Mitbestimmung Der Arbeitnehmer" Und "Betriebsrat". Forschungsprojekt "Einstellungen Zur Mitbestimmung (Einmit)"
Creators: name: Nienhüser, Werner
name: Hoßfeld, Heiko
name: Glück, Esther
name: Gödde, Lukus
Publisher: name: Zenodo
Year: 2018
Subjects: Kodierschema
coding scheme

description: Kodierschema für die Assoziationen der Stimulusbegriffe „Mitbestimmung der Arbeitnehmer“ und „Betriebsrat“. Forschungsprojekt „Einstellungen zur Mitbestimmung (EinMit)“. Mehr dazu auf https://einmit.wordpress.com
[Wappentafel oberhalb des Eingangstores des Schlosses Kyburg]
Creators: name: Rahn, Johann Rudolf
Publisher: name: [s.n.]
Year: 1860

description: Dargestellt wird die in Form einer Wandmalerei angebrachte Wappentafel oberhalb des Eingangtors des Schlosses Kyburg in Kyburg. Rahn hat jedoch in der Mitte der Darstellung nicht das Original wiedergegeben, sondern hat anstelle des Wappens der Kyburger einen Schriftzug, den er unterhalb der Zeichnung nochmals notiert hat, dargestellt
description: [Johann Rudolf Rahn]
Biowaste mixtures affecting the growth and elemental composition of Italian ryegrass
Creators: name: Esperschütz, Jürgen Alexander
name: Lense, Obed Nedjo
name: Anderson, Craig Evan
name: Bulman, Simon
name: Horswell, Jacqui
name: Dickinson, Nicolas M.
name: Robinson, Brett Harvey
Publisher: name: Institute of Environmental Science and Research
Year: 2019
Subjects: Environmental management
Environmental assessment and monitoring
Environmental rehabilitation and restoration
Ecosystem function
Ecology not elsewhere classified

description: Biosolids (sewage sludge) can be beneficially applied to degraded lands to improve soil quality. Plants grown on biosolids-amended soils have distinct concentrations of macronutrients and trace elements, which can be beneficial or present a risk to humans and ecosystems. Potentially, biosolids could be blended with other biowastes, such as sawdust, to reduce the risks posed by rebuilding soils using biosolids alone. We sought to determine the effect of mixing biosolids and sawdust on the macronutrient and trace element concentration of ryegrass over a 5-mo period. was grown in a low fertility soil, typical for marginal farm areas, that was amended with biosolids (1250 kg N ha), biosolids + sawdust (0.5:1) and urea (200 kg N ha), as well as a control. Biosolids increased the growth of from 2.93 to 4.14 t ha. This increase was offset by blending the biosolids with sawdust (3.00 t ha). Urea application increased growth to 4.93 t ha. The biowaste treatments increased N, P, Cu, Mn, and Zn relative to the control, which may be beneficial for grazing animals. Although biowaste application caused elevated Cd concentrations (0.15-0.24 mg kg) five- to eightfold higher than control and urea treatments, these were below levels that are likely to result in unacceptable concentrations in animal tissues. Mixing biosolids with sawdust reduced Cd uptake while still resulting in increased micronutrient concentrations (P, S, Mn, Zn, Cu) in plants. There were significant changes in the elemental uptake during the experiment, which was attributed to the decomposition of the sawdust.