cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Overgrounds and Undergrounds of Pure and Applied Science: Cosmic Collisions and Industrial Collusion
Creators: name: Allen, Jamie
Publisher: name: Springer
Year: 2018
Subjects: subject: infrastructure
subject: archeology
subject: geology
subject: 700 - Künste und Unterhaltung

description: Archeology and geology are presumed to be "pure" knowledge practices, curiosity-driven investigations of the material histories of humankind and the Earth. Underwritten by Enlightenment techniques and tropes like clarity, organisation, cleanliness and illumination, there is in all the sciences a similar drive and imaginary toward a valuation of purity, against application, in all the sciences. These practices of observation, sampling, inscribing, analyzing and publishing are, of course, much more untidy than we sometimes imagine. What other sciences might be possible, were we more sensitive to the complicity of specific material practices as collusive affairs, amalgams of the pure and the applied, the clean and the messy, the ecological and the infrastructural, of light and shadow, of overground and underground?
Platelet preparations in neuronal cell differentiation
Creators: name: Bonazza, Veronica
name: Brunelli, Giorgio
name: Monini, Luisa
name: Castrezzati, Stefania
name: Lonati, Claudio
name: Buffoli, Barbara
name: Borsani, Elisa
name: Rodella, Luigi F.
Publisher: name: Firenze University Press
Year: 2017
Subjects: Concentrated growth factors; neuronal differentiation; SH-SY5Y

description: Concentrated Growth Factors (CGF) is a platelet rich preparation that has the important feature of a tight fibrin network and containing a large number of growth factors possessing great regenerative potentialities [1]. The regeneration of nervous system is one of the mail goal of regenerative medicine. The aim of this study is to test the in vitro CGF effects on both differentiated and undifferentiated SH-SY5Y cells, derived from human neuroblastoma.  To induce differentiation, SH-SY5Y cells have been treated with Retinoic Acid (RA) 10µM, in both basal and complete medium and in the presence and absence of CGF. After 72 hours, different parameters have been investigated: the morphological characteristics of the cells, the cell proliferation, the cellular vitality using the MTT test, the CGF and/or RA differentiation property and the immunocytochemical analysis of neuronal specific markers (NeuN, Sinaptophisine, β-III-tubulin, Nestin). Moreover the NGF (Nerve Growth Factor) and BDNF (Brain Derived Growth Factor) release have been assayed by ELISA test. Our results obtained suggest that treatment with CGF, also used alone, positively affects cell differentiation and neuronal phenotype regulating the expression of the neuronal markers and improving the outgrowth of neurites. Taken together these results seems to be promised into new approaches for neuronal regeneration using platelet preparations.
description: Italian Journal of Anatomy and Embryology, Vol. 122, No. 1 (Supplement) 2017
CARDIAC REHABILITATION AND LIFE AFTER MYOCARDIAL INFARCTION
Creators: name: N.Vanitha
name: Dr. T. Thanga Paneer Selvam
name: Nirmala Asaithambi
name: Hulda Johnson
name: Dr. R Shankar Shanmugam
Publisher: name: Zenodo
Year: 2023
Subjects: Cardiac, Desideratum, Economy, Nursing Intervention.

description: Abstract

BACKGROUND: Myocardial infarction is the major cause of death globally. It also leads to an impact in the change in lifestyle and quality of life among the patients. The study aimed at exploring the impact of cardiac nursing interventions among post myocardial infarction patients in terms of their lifestyle modification, quality of life and adherence to medications. METHODS: This was a qualitative phenomenological study that included 10 samples of post-myocardial infarction patients from a cardiology unit, chosen using purposive sampling approach. The semi structured interview schedule was used to collect data through in-depth interview. The in-depth interview was conducted before (Pre) and after (Post) the Nurse led Cardiac Intervention (rehabilitation). The data collected was analysed using thematic content analysis.  RESULTS: The pre intervention themes included were Desideratum, Futuristic outlook, New Habits, Supportive concerns, Economical deportation and Psychological Inconvenience. The post intervention themes included were Wellness at Hospital, Family, Mental well- being, Getting out of life alive, Physical health, New Practices, and Impact of interventions. CONCLUSION: The results suggest that the cardiac nursing intervention has helped out in transforming the lifestyles of the patients with post myocardial infarction. Furthermore, the preventive aspect is very important to alleviate the detrimental effects of the disease on the patients and their family members. The necessary information will help to transform the life of the patients.
The Organ Care System as a new promising tool for donor heart ex vivo preservation
Creators: name: Bonetti, Antonella
name: Benedetti, Giovanni
name: Cantarutti, Cristina
name: Ferrara, Veronica
name: Contin, Magali
name: Finato, Nicoletta
name: Sponga, Sandro
name: Esposito, Gennaro
name: Livi, Ugolino
name: Ortolani, Fulvia
Publisher: name: Firenze University Press
Year: 2017
Subjects: Organ Care System; heart transplant; cardiomyocyte metabolism; histopathology; ultrastructure

description: Heart transplantation remains the gold standard treatment for end-stage heart failure. To face actual donor shortage, heart warm perfusion with the Organ Care System (OCS) was introduced alternatively to usual cold ischemic storage [1]. Here, OCS-preserved hearts were matched against those subjected to cold ischemia in terms of (i) perioperative clinical parameters, (ii) histopathological, immunohistochemical, and ultrastructural features of pre- and post-implant left ventricle biopsies, and (iii) cardiomyocyte metabolism by NMR spectroscopy of blood samples. Concerning clinical outcomes and myocardium structural preservation, preliminary data seem to be encouraging. Namely, NMR spectra revealed OCS perfusion to reduce cardiomyocyte oxidative stress by lowering the lactate/glucose ratio. Ultrastructurally, cardiomyocytes from OCS-preserved hearts showed minor hypertrophy signs and few altered mitochondria. OCS preservation also seemed to mitigate reperfusion effects, decreasing the number of degenerating cardiomyocytes. Interestingly, disappearance of sarcomere banding in one heart undergone pre-explant arrest was found to be restored after OCS perfusion. In conclusion, these preliminary data suggest that the OCS can improve heart storage. Functional recovery of borderline hearts with actual broadening of the donor pool seems to represent additional advantages of OCS technology.
description: Italian Journal of Anatomy and Embryology, Vol. 122, No. 1 (Supplement) 2017
Managing, restoring and creating ponds and  pondscapes for climate change adaptation
Creators: name: Biggs
name: Hoyle, Sarah
Publisher: name: Zenodo
Year: 2025

description: An information poster, designed for the general public, covering:

Management, restoration and 'resurrection', and creation of ponds as nature-based solutions

The pond management-restoration continuum

The benefit of a pond complex, compared to an individual pond

This poster was created for the Horizon 2020 PONDERFUL project. It is one in a series of five information posters created for the project.
Leitfaden zur Weiterentwicklung kantonaler Systeme im Übergang Schule - Ausbildung - Arbeitsmarkt. Mit Fokus auf Unterstützungsbedürfnisse von jungen Menschen mit Mehrfachproblematiken
Creators: name: Schaffner, Dorothee
name: Heeg, Rahel
name: Chamakalayil, Lalitha
name: Schmid, Magdalene
Publisher: name: Bundesamt für Sozialversicherungen BSV
Year: 2022
Subjects: subject: Übergangssystem
subject: Mehrfachproblematiken
subject: Bedarfsorientierung
subject: Interinstitutionelle Zusammenarbeit
subject: 370 - Erziehung, Schul- und Bildungswesen

description: Der Leitfaden entstand im Rahmen der Auftragsstudie "Unterstützung von Jugendlichen und jungen Erwachsenen mit Mehrfachproblematiken entlang der Nahtstellen I und II". Er zeigt Herangehensweisen und Lösungsansätze, um die kantonalen Übergangssysteme weiterzuentwickeln. Damit verbunden ist das Ziel, bedarfsorientierte Angebote für junge Menschen mit komplexen Problemlagen bereitzustellen.
Melatonin atheroprotective effects in vivo
Creators: name: Bonomini, Francesca
name: Favero, Gaia
name: Nardo, Lorenzo
name: Facchetti, Luca
name: Seo, Youngho
name: Pampaloni, Miguel Hernandez
name: Giugno, Lorena
name: Maroldi, Roberto
name: Rezzani, Rita
Publisher: name: Firenze University Press
Year: 2017
Subjects: Atherosclerosis; inflammation; melatonin; oxidative stress; 18F-FDG PET.

description: Chronic inflammatory fibro-proliferative changes leading to atherosclerotic plaques are considered hallmark of cardiovascular diseases [1]. Atherosclerosis pathogenesis is a complex entity, which has not been fully understood; however, many studies have demonstrated the role of oxidative stress and inflammation in its development. Melatonin effects on inflammation and oxidative stress process have been demonstrated in the last ten-year literature [2]. However, its role(s) and mechanism(s) of action as a therapeutic tool against atherosclerosis remain largely unexplored. Our aims were to assess the role of melatonin in the onset and developing of atherosclerotic plaques through radiologic and morphometrical tools in 20 apolipoprotein-E knockout (ApoE) mice fed with Western diet (42% calories from fat). 10/20 mice were treated with melatonin (10 mg/kg per os). 18F-FDG PET-CT is a widely used tool to assess inflammatory changes, even before macroscopic changes have taken place. Glucose metabolism is known to be higher in areas of inflammation due to an increased expression of GLUT transporters on the cell membranes both in animals and humans. Using this feature PET/CT is able to determinate metabolic cellular changes and therefore it can be used as biomarker of atherosclerosis. All mice were scanned both before starting melatonin treatment and at the end of the study. After the last scan mice were sacrificed and vascular remodeling, oxidative stress and inflammation at aortic arch level were evaluated. CT-corrected PET datasets were used for computation of SUVmax. Atherosclerotic vascular remodeling, oxidative stress and inflammation levels were significantly more conspicuous in the control cohort, compared to the treated mice (p≤0.05). 18F-FDG PET/CT did not show significant difference in SUVmax. In summary, also in vivo, melatonin may have a protective effect in the atherosclerotic pathogenesis. Flamma S.p.A.-Italy (www.flammagroup.com) provided with melatonin. Financial supports: Fondazione Cariplo e Regione Lombardia “New opportunities and ways towards ERC” (Project 2014-2256) and University of California - Radiology and Biomedical Imaging Nuclear Medicine Section.
description: Italian Journal of Anatomy and Embryology, Vol. 122, No. 1 (Supplement) 2017
Ischemic colitis following left antegrade sclerotherapy for idiopathic varicocele: the role of forensic clinical anatomy
Creators: name: Boscolo-Berto, Rafael
name: Macchi, Veronica
name: Porzionato, Andrea
name: Morra, Aldo
name: De Caro, Raffaele
Publisher: name: Firenze University Press
Year: 2017
Subjects: Forensic clinical anatomy; antegrade sclerotherapy; internal spermatic vein; left colic vein; anatomical variation; ischemic colitis

description: Introduction. The Tauber procedure, i.e. antegrade sclerotherapy for varicocele, can be complicated by ischemic colitis. Its possible pathogenesis is referred to the presence of an atypical kind of portal-systemic communication, which could represent an unfrequently reported anatomic variant. Aim of this study is to solve this anatomical controversy of utmost clinical usefulness. Materials and methods. A computer-aided and hand-checked systematic review of the literature was implemented to identify relevant publications on the topic. Moreover, we reviewed the computed tomography CT-scan of a clinical case with medico-legal implications due to severe vascular complication following Tauber’s procedure. Results. Despite specific References were made on the issue in more dated hardbacks since the 19th century, only a few clinical cases reporting an ischemic colitis following the Tauber’s procedure were found in contemporary literature. By reviewing the CT-scan images of a filed lawsuit we found traces suggestive for the presence of a significant communication between the internal spermatic and the left colic vein, as part of the portal-systemic anastomoses. Conclusions. A significant anatomical finding identified in the past have been under-reported and subsequently underestimated in its clinical value. For the first time we demonstrated its pathophysiological role in a real clinical scenario, coupling the anatomical variation to the clinical complication hence stressing that its knowledge is of utmost importance to raise the scientific awareness and to prevent possible devastating complication in clinical daily practice. Progress in the medical field coupled with increased medical-legal awareness has supported the ripening of clinical anatomy and forensic clinical anatomy, whose multidisciplinary represents the best way to recover and hand down the medical knowledge at risk of being forgotten.
description: Italian Journal of Anatomy and Embryology, Vol. 122, No. 1 (Supplement) 2017
Effects of the endoplasmic reticulum signaling pathway on cadmium-induced impairment of the blood brain barrier
Creators: name: Branca, Jacopo J.V.
name: Maresca, Mario
name: Morucci, Gabriele
name: Paternostro, Ferdinando
name: Di Cesare Mannelli, Lorenzo
name: Gulisano, Massimo
name: Pacini, Alessandra
Publisher: name: Firenze University Press
Year: 2017
Subjects: Cadmium neurotoxicity; blood brain barrier; ER stress; caspase-3 activation; tight junctions dislocation

description: Due to its high permeability to blood-brain barrier (BBB), cadmium (Cd) has been regarded as a possible etiological factor for human neurodegenerative diseases, such as Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease [1]. However, the mechanism underlying cadmium-induced BBB permeability remains unclear. In this study, we investigated the effect of Cd in RBE4 cells (rat brain endothelial cells) and delineated the signaling pathway that, triggering endoplasmic reticulum (ER) stress and caspase 3 activation, leads to cytoskeleton disorganization and tight junctions disassembly. Our results demonstrate a possible downstream pathway mediated through the Cd-dependent ER stress, assessed by the cytoplasmic expression of an ER protein GRP78, and the consequent caspase-3 activation that results in an extracellular ATP increase, which in turns induces a dislocation, evaluated by immunofluorescent staining, of Zonula Occludens-1 (ZO-1), a tight junction protein, and F-actin. These findings, whereby Cd-induced permeabilization of BBB through a ER stress-dependent pathway on endothelial cells represent a possible novel mechanism of action for Cd that could explain, at least in part, the Cd-related central effects.
description: Italian Journal of Anatomy and Embryology, Vol. 122, No. 1 (Supplement) 2017
Additional file 1 of Application of multiple sgRNAs boosts efficiency of CRISPR/Cas9-mediated gene targeting in Arabidopsis
Creators: name: Li, Jing
name: Kong, Dali
name: Ke, Yongping
name: Zeng, Wenjie
name: Miki, Daisuke
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: Additional file 1: Fig S1. Sequencing results representing the precise GFP-KI of the EMB2410 and ROS1 loci in T1 transgenic plants. Diagrams represent detailed GFP-KI sites for EMB2410 (A) and ROS1 (B) loci. Sequencing chromatograms show the precise GFP-KI GT events in the T1 generation as determined by Sanger sequencing. Fig S2. Detailed diagram of GFP knock-in donor constructs with multiple sgRNAs. Fig S3. Detailed characterization of imprecise GT events. A, Genotyping of imprecise GT events in ROS1-GFP-sg24. Both precise and imprecise GT events were detected by the 5′ arm specific primers. Heritable and imprecise GT events were observed in the 5′ homologous arm region in three independent ROS1-GFP-sg24 plants of the T2 generation. B, Chromatograms of Sanger sequence results. Protospacer-adjacent motif (PAM) are indicated in red letters, mutations are indicated in small green letters.
Neuerungen im GEAK Tool
Creators: name: Hall, Monika
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2022
Subjects: subject: GEAK
subject: 624 - Ingenieurbau und Umwelttechnik

description: Neuerungen im GEAK Tool für V.6.0.0.: Wechsel SIA 380/1:2009:2016, Neuerungen im Bereich Heizung und Warmwasser und Einführung von CO2-Etiketten.
An online movement and tremor identification algorithm for evaluation during deep brain stimulation
Creators: name: Bourgeois, Frédéric
name: Pambakian, Nicola
name: Coste, Jérôme
name: Lange, Ijsbrand De
name: Lemaire, Jean-Jacques
name: Hemm-Ode, Simone
Publisher: name: De Gruyter
Year: 2022
Subjects: subject: Tremor estimation
subject: Weighted-frequency Fourier Linear combiner
subject: Deep brain stimulation
subject: Microelectrode recording
subject: Digital biomarker
subject: 600 - Technik, Medizin, angewandte Wissenschaften

description: INTRODUCTION: Deep brain stimulation (DBS) is widely used to alleviate symptoms of movement disorders. During intraoperative stimulation the influence of active or passive movements on the neuronal activity is often evaluated but the evaluation remains mostly subjective. The objective of this paper is to investigate the potential of a previously developed Weighted-frequency Fourier Linear combiner and Kalman filter-based recursive algorithm to identify tremor phases and types. METHODS: Ten accelerometer recordings from eight patients were acquired during DBS from which 186 phases were manually annotated into: rest, postural and kinetic phase without tremor, and rest, postural and kinetic phase with tremor. The method first estimates the instantaneous tremor frequency and then decomposes the motion signal into voluntary and tremorous parts. The tremorous part is used to quantify tremor and the voluntary part to differentiate rest, postural and kinetic phases. RESULTS: Instantaneous tremor frequency and amplitude are successfully tracked online. The overall accuracy for tremorous phases only is 89.1% and 76.3% when also non-tremorous phases are considered. Two main misclassification cases are identified and further discussed. CONCLUSION: The results demonstrate the potential of the developed algorithm as an online tremorous movement classifier. It would benefit from a more advanced tremor detector but nevertheless the obtained digital biomarkers offer an evidence-based analysis and could optimize the efficacy of DBS treatment.
title: "Ihre Sorgen möchten wir haben"
Creators: name: Wallner, Mario Paul
Year: 2008

description: In der vorliegenden Arbeit werden die wesentlichen Berechnungsgrundlagen zur Lebensversicherungsmathematik behandelt. Die Arbeit ist didaktisch so gestaltet, dass sie auch von Leuten, die sich vorher noch nie mit dieser Materie beschäftigt haben, verstanden werden kann. Eine gewisse mathematische Allgemeinbildung sollte jedoch schon vorhanden sein um die Arbeit zu verstehen. In der heutigen Zeit, wo beinahe jede Person in irgendeiner Art und Weise versichert ist und die meisten Leute auch eine Lebensversicherung, sei es als Altersabsicherung oder als Kapitalanlage, abgeschlossen haben, sind Begriffe wie Prämien, Versicherungssumme oder Versicherungslaufzeit allgegenwärtig. Auf diversen Websites von Versicherungsgesellschaften kann man mittels eines so genannten "Prämienkalkulators" unter Eingabe der erforderlichen Daten berechnen lassen, wie hoch die monatlichen, vierteljährlichen bzw. jährlichen Prämien für eine bestimmte Versicherung ausfallen werden. Diese Arbeit soll interessierten Lesern und Leserinnen einen Einblick darin gewähren, wie die Prämienkalkulation grundsätzlich funktioniert. Auch der wesentliche Aspekt des Einbeziehens der Kosten, die beim Abschluss einer Versicherung entstehen, in die Prämienkalkulation wird aufgezeigt. Die praktische Anwendung der angeführten und hergeleiteten Formeln wird in zahlreichen Beispielen numerisch illustriert. Dies soll wesentlich zum besseren Verständnis der Thematik beitragen. Der inhaltliche Aufbau ist so gestaltet, dass nach einer allgemeinen Begriffserläuterung und einem geschichtlichen Abriss zuerst auf die mathematischen Hintergründe wie Finanzmathematik, Rentenrechnung und Wahrscheinlichkeitstheorie, die für das Verständnis dieses Themengebiets erforderlich sind, eingegangen wird. Nach einem kurzen Überblick über die Berechnung von verschiedenen (Versicherungs-)Leistungsbarwerten werden die Prämienbarwerte von Nettoprämien und Nettodeckungskapitalien behandelt. Dann wird auf eine häufig abgeschlossene Versicherungsart, nämlich der Versicherung auf mehrere Leben, eingegangen. Abschlieÿend soll das Kapitel über den Einbezug der Kosten den Themenkomplex abrunden.
Additional file 2 of Application of multiple sgRNAs boosts efficiency of CRISPR/Cas9-mediated gene targeting in Arabidopsis
Creators: name: Li, Jing
name: Kong, Dali
name: Ke, Yongping
name: Zeng, Wenjie
name: Miki, Daisuke
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: Additional file 2: Table S1. Prediction scores for EMB2410 and ROS1 sgRNAs. The sgRNAs activities were predicted by using CRISPOR online website ( http://crispor.tefor.net/ ). Table S2. Other candidate sgRNAs for EMB2410 and ROS1 loci. The mutation efficiencies were noted by CRISPROR.
Repositorium, Publikationsdatenbank und Katalog : Integrierte Lösungen für kleine Bibliotheken
Creators: name: Mehl, Rebecca
name: Piegler, Maike
name: Wagner, Alexander
name: Welch, Christian
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2018

description: Open Access Tage 2018, OAT2018, Graz, Austria, 24 Sep 2018 - 26 Sep 2018
description: Die DESY Bibliothek ist an den beiden Standorten Hamburg und Zeuthen für die umfassende und hochwertige Literatur- und Informationsversorgung der Mitarbeiterinnen und Mitarbeiter des Deutschen Elektronen-Synchrotrons DESY sowie darüber hinaus von jährlich mehr als 3000 Gastwissenschaftlerinnen und -wissenschaftlern aus über 40 Nationen verantwortlich. Ihr Dienstleistungsportfolio umfasst ferner den Eigenverlag, Dienstleistungen rund um das wissenschaftliche Publizieren und die maßgebliche Partnerschaft an der Hochenergiephysikdatenbank INSPIRE.Gerade für eine kleine Bibliothek stellen derartige Anforderungen eine Herausforderung auch an die Geschäftsgänge dar. Um bei der Ablösung des bisherigen Aleph-Katalogs möglichst Synergieeffekte zu nutzen, wurde dieser daher mit Repositorium und Veröffentlichungsdatenbank zu einem System fusioniert, welches als zentraler Hub Zugriff auf ca. 40.000 Titel des Bibliotheksbestands und ca. 52.000 Eigenpublikationen (davon etwa 25.000 Open Access) bietet. Darüber hinaus werden im Rahmen eines Patron Driven Acquisition Modells weitere, fachlich vorselektierte Titel zur Recherche angeboten die direkt zur Anschaffung vorgeschlagen werden können. Integriert sind ferner die Nutzerverwaltung sowie die Literaturerwerbung. Um eine 24h-Öffnung anbieten zu können setzt die DESY Bibliothek eine RFID-basierte Selbstverbuchungslösung ein.Als Basis dient die Repository Software INVENIO, deren entsprechende Anpassungen hier vorgestellt werden. Diese erlauben neben dem Bestandsnachweis auch die Abbildung der Verlagsprozesse oder die transparente Behandlung von Publikationsgebühren (APC) und verbessert die Vollständigkeit der Außendarstellung des Zentrums. Anders als bei Discovery Systemen ist die vorgestellte Lösung nicht nur ein Suchindex, sondern integrales Arbeitsmittel der Bibliothek. Das stattgefundene Insourcing bietet dabei zahlreiche Chancen und Risiken die ebenfalls diskutiert werden sollen. Um nicht einsam auf einem Leuchtturm zu enden, finden diese Entwicklungen im Rahmen von JOIN² statt.
Ökosystem Heim als entkoppelte Welt: Perspektiven von Care Leavern auf den Sozialisationskontext Heim
Creators: name: Ahmed, Sarina
name: Rein, Angela
name: Schaffner, Dorothee
Publisher: name: Universität Zürich, Institut für Erziehungswissenschaft
Year: 2021
Subjects: Ökosystem Heim
Sozialisation
Leaving Care

description: Im Fokus des Beitrags stehen die Fragen, wie Care Leaver sprich Jugendliche und junge Erwachsene, die das Heim verlassen haben, den Sozialisationskontext stationäre Erziehungshilfe wahrnehmen und welche fachlichen und fachpolitischen Schlussfolgerungen sich hieraus ziehen lassen. Zum einen wird aufgezeigt, inwiefern die stationäre Einrichtung Heim von den Befragten als ein von der Aussenwelt separierter Kontext erlebt wird. Zum anderen wird diskutiert, welche Bedeutung die spezifische Kontur und Strukturierung dieses Sozialisationskontextes Heim auf die Lebenslage Leaving Care hat. Die Befunde der Studie geben Impulse für eine lebensweltorientierte Weiterentwicklung der Praxis der Heimerziehung und für die Unterstützung von Leaving-Care-Prozessen, die das Leben „in Care“ stärker mit Prozessen des Leaving Care verknüpft.
Hirmeos Collaborative Web Platform
Creators: name: HIRMEOS Consortium
Publisher: name: Zenodo
Year: 2017
Subjects: open access
open science
social sciences and humanities
monograph

description: This document is a project deliverable of the HIRMEOS project.

The "collaborative web platform" hereby describes the communication tools and means used by the participants of the HIRMEOS project for general internal communication, for coordination and management of the task implementation and for file sharing and storage.

This document also constitutes a user guide for the Work Package (WP) leaders and participants.Different aspects of the communication between participants will be addressed in this document:

	Internal communication within the HIRMEOS project.
	Sharing, sending, storage and organization of the files related to the project.
	Common policies regarding the management of the files.
	Use of a project management tool for up-to-date information.
	Elaboration of a deliverable template.
title: Die "Erfindung" von Saatgut in Österreich
Creators: name: Bosin, Bettina
Year: 2008

description: Die "Erfindung" von Saatgut in Österreich und die Entstehung des ersten Saatgutgesetzes 1934 waren Entwicklungsprozesse, die von komplexen Netzwerken bestimmt wurden. Viele verschiedene Akteure suchten in Diskussions- und Verhandlungsprozessen gemeinschaftlich eine neue Definition von Saatgut, weshalb von der "Erfindung" von Saatgut gesprochen wird. In dieser Arbeit wird die Ko-Produktion des Begriffes "Saatgut" durch die Ansprüche und Möglichkeiten der beteiligten Personen aus Wissenschaft und Gesellschaft verdeutlicht. Es wird gezeigt das die vereinbarte Definition durch ein Gesetz praktisch Umsetzung erfährt und die Ko-Produktion eines Begriffes so in den Alltag vieler Menschen getragen wird. Die konstruierte Definition von Saatgut beinhaltet auch die Vermischung von Kultur und Natur, nach der die Akteur - Netzwerk - Theorie aus den Science- und Technology Studies sucht. Mit verschiedenen Annahmen der Actor - Network - Theory wird ein differenzierter Blick auf die Verflechtungen und Mechanismen geworfen, die zur Formulierung des Gesetzes führten. Der Fokus hierbei liegt auf der Untersuchung der Methoden und Materialien, die dazu beitrugen, Wissen und Macht zu generieren, um die jeweiligen Interessen im Gesetz durchzusetzen. Die Rolle "der Wissenschaft" als Vermittlerin zwischen der Welt der Menschen und der Natur des Saatgutes sowie die Verwissenschaftlichung der Landwirtschaft in der ersten Hälfte des 20. Jahrhunderts in Österreich sind Schwerpunkte dieser Diplomarbeit.
Additional file 3 of Application of multiple sgRNAs boosts efficiency of CRISPR/Cas9-mediated gene targeting in Arabidopsis
Creators: name: Li, Jing
name: Kong, Dali
name: Ke, Yongping
name: Zeng, Wenjie
name: Miki, Daisuke
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: Additional file 3: Table S3. Mutation pattern. The percentage of mutation patterns were analyzed in different GT-negative GFP T1 transgenic plants referring to the EMB-sgRNA5 and ROS1-sgRAN2 target locus, negative values represent the number of deleted bases and positive values represent the number of inserted bases. Table S4. Predicted off-target loci. The off-target loci were predicted by using CRISPR-GE online website ( http://skl.scau.edu.cn ). Table S5. Mutation frequencies of predicted off-target sites. Mutation frequencies were analyzed by PCR followed by sequencing using the T1 transformants. Table S6. Sequences of primers.
title: Virus
Creators: name: Petritsch, Barbara
Year: 2008

description: Diese Arbeit ist im Fokus der visuellen Kulturgeschichte entstanden und setzt sich mit der Visualisierung bzw. den Visualisierungen des, für das Auge und für optische Hilfsmittel, unsichtbaren Virus auseinander. Das Virus wird hier als Objekt der Wissensproduktion verstanden, dass einerseits verschiedenste Bedeutungen annehmen kann (biologischer Virus, Computervirus, wissenschaftliches Forschungsobjekt, Krankheitserreger in der Medizin, Sozialschmarotzer,...), andererseits anhand ähnlicher bis deckungsgleicher Darstellungsmuster (z.B. Kriegs- und Kampfmetaphorik) konstruiert wird. Der zeitliche Rahmen ist mit dem 20. Jahrhundert abgesteckt. Die Darstellung beginnt mit der Konstruktion des wissenschaftlichen Objekts Virus, zu Beginn des 20. Jahrhunderts, um sich in der Folge vor allem auf die Übertragung des Begriffes auf andere gesellschaftliche Bereiche (ab den 1940ern) zu konzentrieren. Hier wird vor allem das Virus als Objekt sowie seine metaphorische Anwendung in Augenschein genommen und die wechselseitige Beeinflussung in der Bedeutungsproduktion zwischen den kulturellen Sphären (Wissenschaft, Öffentlichkeit, Film, Politik ...). An diese Analyse angelehnt werden zumeist filmische Einzelbeispiele der Visualisierung besprochen um allgemeine Aussagen zu veranschaulichen.
Additional file 4 of Application of multiple sgRNAs boosts efficiency of CRISPR/Cas9-mediated gene targeting in Arabidopsis
Creators: name: Li, Jing
name: Kong, Dali
name: Ke, Yongping
name: Zeng, Wenjie
name: Miki, Daisuke
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: Additional file 4: Fig S4. Original uncropped gel pictures.
Bioengineering of anti-inflammatory natural products
Creators: name: Winand, Lea
name: Sester, Angela
name: Nett, Markus
Publisher: name: TU Dortmund
Year: 2020
Subjects: subject: Anti-inflammatory
subject: Biocatalysis
subject: Biosynthesis
subject: Mutasynthesis
subject: Natural products
subject: 660

description: Inflammatory processes occur as a generic response of the immune system and can be triggered by various factors, such as infection with pathogenic microorganisms or damaged tissue. Due to the complexity of the inflammation process and its role in common diseases like asthma, cancer, skin disorders or Alzheimer's disease, anti-inflammatory drugs are of high pharmaceutical interest. Nature is a rich source for compounds with anti-inflammatory properties. Several studies have focused on the structural optimization of natural products to improve their pharmacological properties. As derivatization through total synthesis is often laborious with low yields and limited stereoselectivity, the use of biosynthetic, enzyme-driven reactions is an attractive alternative for synthesizing and modifying complex bioactive molecules. In this minireview, we present an outline of the biotechnological methods used to derivatize anti-inflammatory natural products, including precursor-directed biosynthesis, mutasynthesis, combinatorial biosynthesis, as well as whole-cell and in vitro biotransformation.
description: ChemMedChem;16(5)
Numerical estimation of the geometry and temperature of an alternating current steelmaking electric arc
Creators: name: Hernández, Jesús D.
name: Onofri, Luca
name: Engell, Sebastian
Publisher: name: TU Dortmund
Year: 2020
Subjects: subject: Electric arcs
subject: Elenbaas-Heller equation
subject: Minimum entropy production
subject: Plasma
subject: Steelmaking
subject: 660

description: A channel arc model (CAM) that predicts the temperature and the geometry of an electric arc from its voltage and impedance set-points is presented. The core of the model is a nonlinear programming (NLP) formulation that minimizes the entropy production of a plasma column, the physical and electrical properties of which satisfy the Elenbaas–Heller equation and Ohm's law. The radiative properties of the plasma are approximated utilizing the net emission coefficient (NEC), and the NLP is solved using a global numerical solver. The effects of the voltage and impedance set-points on the length of the electric arc are studied, and a linear formula that estimates the length of the arc in terms of its electrical set-points is deducted. The length of various electric arcs is measured in a fully operative electric arc furnace (EAF), and the results are used to validate the proposed models. The errors in the predictions of the models are 0.5 and 0.4 cm. In comparison, the existing empirical and Bowman formulae estimate the length of the experimental arcs with errors of 2.1 and 2.6 cm. A simplified formula to estimate the temperature of an electric arc in terms of its electrical set-points is also presented.
description: Steel research international;92(3)
Additional file 1 of IGT/LAZY genes are differentially influenced by light and required for light-induced change to organ angle
Creators: name: Waite, Jessica Marie
name: Dardick, Christopher
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 1: Fig. S1. Cartoon description of angle measurements used in this study. Fig. S2. tac1 lazy1 and lazy1 lazy6 mutants largely phenocopy lazy1 mutants in constant light and dark conditions. Fig. S3. Quadruple lazy/dro mutant tip angles exhibit insensitivity to high and low light, while lazy1 mutants appear hypersensitive. Fig. S4. LAZY6 is expressed in shoot vasculature through 28 dpg. Fig. S5. Overexpression of LAZY1, DRO1, and LAZY6, alters light-induced branch angle phenotypes in a lazy1 mutant background. Fig. S6. LAZY and DRO genes contain several types of light-related cis-elements. Fig. S7. LAZY and DRO gene expression shows differing responses to light changes in seedling shoot and roots.
title: Richard Serra - Philip Glass
Creators: name: Vogl, Christiane
Year: 2008

description: In dieser Arbeit soll den Gemeinsamkeiten im Werk von Richard Serra und Philip Glass nachgegangen werden. Ausgehend von der Analyse von Serras Arbeiten werden die drei prägnantesten Korrelationen mit den (frühen) Arbeiten von Glass – nämlich Prozess, Zeit und Linie - aufgezeigt und untersucht werden. Interdependenzen und individuelle Leistungen beider Künstler sollen ebenso betrachtet werden, wie die Entwicklung der Werke im Laufe der Zeit, frei nach Serras Zitat „work comes out of work“: die Verlagerung von Interessen und der Wandel von Problemstellungen. Nicht zuletzt soll auf die Bedeutung von medienübergreifenden Problemstellungen und Problemlösungen in der Kunst hingewiesen werden, die nicht nur auf Glass und Serra im speziellen zutreffen, sondern auch generell Gültigkeit haben.
Do firms hedge in order to avoid financial distress costs? New empirical evidence using bank data
Creators: name: Hahnenstein, Lutz
name: Köchling, Gerrit
name: Posch, Peter N.
Publisher: name: TU Dortmund
Year: 2020
Subjects: subject: Bankruptcy costs
subject: Corporate hedging
subject: Financial distress
subject: Derivatives
subject: 330
subject: Insolvenz
subject: Hedging

description: We present a new approach to test empirically the financial distress costs theory of corporate hedging. We estimate the ex-ante expected financial distress costs, which serve as a starting point to construct further explanatory variables in an equilibrium setting, as a fraction of the value of an asset-or-nothing put option on the firm's assets. Using single-contract data of the derivatives' use of 189 German middle-market companies that stems from a major bank as well as Basel II default probabilities and historical accounting information, we are able to explain a significant share of the observed cross-sectional differences in hedge ratios. Hence, our analysis adds further support for the financial distress costs theory of corporate hedging from the perspective of a financial intermediary.
description: J Bus Fin Account;48(3-4)
Zinc protection in cadmium-induced Blood Brain Barrier permeability: a metabolic and morphological in vitro study
Creators: name: Branca, Jacopo J.V.
name: Di Cesare Mannelli, Lorenzo
name: Maresca, Mario
name: Paternostro, Ferdinando
name: Bonechi, Sofia
name: Morucci, Gabriele
name: Gulisano, Massimo
name: Pacini, Alessandra
Publisher: name: Firenze University Press
Year: 2017
Subjects: Zinc; Cadmium; BBB permeability; morphology; in vitro study

description: Cadmium (Cd) is a worldwide occupational and environmental pollutant [1]. Cd toxicity is widely known and studied in many tissues and organs such as testis, kidney, liver, lung and brain [2,3]. On the other hand, zinc (Zn) is a trace element known as coenzyme for many proteins such as methallothionein [4]. To date, very little is known about the role of Cd and Zn in BBB permeability. To study their effects in BBB permeability in vitro, the RBE4 cell line was used and different concentrations of CdCl2 and ZnCl2 were tested. Metabolic activity (MTT assay) was performed to test the protective and preventive role of ZnCl2 on CdCl2 toxicity. Western blotting analysis was used to better investigate the molecular pathway involved in Cd-induced BBB permeability evaluating GRP78 (ER stress marker) and caspase-3 protein expression levels. Furthermore, ZO-1 and F-actin immunofluorescent staining was performed to better understand the morphological alterations and BBB permeability achieved by Cd treatment. Our preliminary data highlight the role of Cd in evoking BBB permeability by F-actin and ZO1 dislocations, triggering the caspase-3 molecular pathway activation induced by GRP78-ER stress increase. Moreover, the data clearly show how Zn is able to counteract the metabolic impairment induced by Cd treatment. Taken together these data point out the possible role of Zn in counteracting the Cd-induced BBB impairment.
description: Italian Journal of Anatomy and Embryology, Vol. 122, No. 1 (Supplement) 2017
title: Autocorrelation-based factor analysis and nonlinear shrinkage estimation of large integrated covariance matrix
Creators: name: Hu, Qilin
Publisher: name: London School of Economics and Political Science (LSE)
Year: 2016
Subjects: subject: H Social Sciences
subject: HA Statistics

description: The first part of my thesis deals with the factor modeling for high-dimensional time series based on a dimension-reduction viewpoint. we allow the dimension of time series N to be as large as, or even larger than the sample size of the time series. The estimation of the factor loading matrix and subsequently the factors are done via an eigenanalysis on a non-negative definite matrix constructed from autocorrelation matrix. The method is dubbed as AFA. We give explicit comparison of the convergence rates between AFA with PCA. We show that AFA possesses the advantage over PCA when dealing with small dimension time series for both one step and two step estimations, while at large dimension, the performance is still comparable.
 The second part of my thesis considers large integrated covariance matrix estimation. While the use of intra-day price data increases the sample size substantially for asset allocation, the usual realized covariance matrix still suffers from bias contributed from the extreme eigenvalues when the number of assets is large. We introduce a novel nonlinear shrinkage estimator for the integrated volatility matrix which shrinks the extreme eigenvalues of a realized covariance matrix back to acceptable level, and enjoys a certain asymptotic efficiency at the same time, all at a high dimensional setting where the number of assets can have the same order as the number of data points. Compared to a time-variation adjusted realized covariance estimator and the usual realized covariance matrix, our estimator demonstrates favorable performance in both simulations and a real data analysis in portfolio allocation. This include a novel maximum exposure bound and an actual risk bound when our estimator is used in constructing the minimum variance portfolio.
title: Teleki József (1738-1796)
Creators: name: Frast, Anna
Year: 2008

description: Im Zentrum der Arbeit steht die historische Persönlichkeit des ungarischen Grafen Teleki József (1738-1796). Er ist ein Vertreter der feudalistischen Ordnung, doch gebildet im Geist der Aufklärung. Obgleich er die Tradition seines Landes bewahren will, ist er dennoch ein Mittler im Kulturtransfer zwischen dem aufgeklärten Westeuropa und einem Osteuropa mit verzögerter Entfaltung der Aufklärung. In der Literatur findet sich als Deutung dieser Gegensätzlichkeit der Hinweis auf Widersprüche in seinen Tätigkeiten für Ungarn. Den beiden Fragenkomplexen Kavalierstour und Kulturtransfer wird ein Überblick über die historische Situation Frankreichs und Ungarns im 18. Jahrhundert vorangestellt. Die Sicht auf die beiden Länder gilt vor allem ihrer Darstellung als Reiseländer. Anschließend wird auf die Bedeutung der adeligen Erziehungsreise hingewiesen. Dabei wird ihre lang währende Gültigkeit innerhalb der adeligen Erziehung sowie ihr Wandel hinsichtlich ihrer Ausbildungsfunktion dargestellt. Teleki macht zur Vollendung seiner Erziehung eine Kavalierstour in das aufgeklärte Westeuropa. Nach Abschluss seiner Studien in der Schweiz reist er über Holland nach Paris. Hier sucht er die Begegnung mit französischen Gelehrten und stellt sich in Versailles und beim französischen Adel vor. Er besucht die Einrichtungen der Wirtschaft und der Technik und Institutionen des Staates. In seinem Reisetagebuch hält er sein Reiseerlebnis fest. Nach seiner Rückkehr in die Heimat bekleidet er hohe Ämter. Die zweite Fragestellung richtet sich auf seine Mittlertätigkeit im Kulturtransfer des 18. Jahrhunderts. Das von den Kulturhistorikern Michel Espagne und Michael Werner entwickelte Konzept des Kulturtransfers kennt keine hierarchische Zuordnung von Kulturen und deutet Kulturtransfer-Prozesse als komplexes Geschehen. Nicht der Vergleich oder die Analyse beider Systeme ist das Ziel, sondern das Erkennen des Prozess-Charakters des Kulturtransfers. Telekis Mittlertätigkeit im Transfer von Wissen und Gedanken der Aufklärung wird an Hand des Konzeptes beschrieben. Hier stehen die Aspekte des Transfers von Büchern sowie des Transfers von Gedanken der Aufklärung zum Schutz der Tradition und zur Gewährung von religiöser Toleranz in Ungarn im Vordergrund. In der ungarischen Literatur wird die Spannung zwischen Telekis beharrenden feudalistischen Bestrebungen und seiner Bildung im Geist der Aufklärung betont. Durch den Ansatz des Konzepts lösen sich Widersprüche in seinen späteren Tätigkeiten auf und seine Mittlerrolle erfährt eine neue Bewertung.
TLQP peptides in Amyotrophic Lateral Sclerosis
Creators: name: Brancia, Carla
name: Noli, Barbara
name: Boido, Marina
name: Vercelli, Alessandro
name: Bongioanni, Paolo
name: Ferri, Gian-Luca
name: Cocco, Cristina
Publisher: name: Firenze University Press
Year: 2017
Subjects: ALS; VGF; TLQP peptides; motor neurons

description: TLQP peptides (TLQPp) act on synaptic strengthening or against neuronal apoptosis but their involvement in Amyotrophic Lateral Sclerosis (ALS) is not well known. We used an ALS animal model (SOD1-G93A) and human tissues (plasma and fibroblasts from both patients and controls), to address the TLQPp expression and their modulation in ALS mechanisms. Mouse motor neuronal cells (NSC-34), were used to study the neuroprotective role of the TLQP-21 against oxidative stress induced by Sodium Arsenite. TLQPp were immunoquantified by ELISA, their cell expression studied by immunofluorescence while cell viability was addressed by MTT assay. In the NSC-34 naïve cells, TLQPp were found within the cytoplasm, axons and growth cones. Upon stress, they appeared immunolocalized exclusively within a cytoplasmatic area, close to the nucleus, (probably the Golgi). Moreover, under stress, TLQPp levels were reduced (42%, p=3.1x10-6), while the exogenous increase of TLQP-21 improved cell viability (13%, p= 0.018). In naïve fibroblasts, TLQPp were also similarly localized in an area, likely the Golgi, of patients and controls while their reduction (31%, p=0.03) was observed in cells with TARDBP-A382T mutation. Stress granules only appeared after SA treatment, and did not contain TLQPp. In plasma, a reduced release of TLQPp was associated with the beginning of the clinical motor symptoms in patients (12%, p=0.026), and with a pre-symptomatic stage in mutant mice (26.3%, p=0.048). Finally, in mouse spinal cord we identified by vescicular acetylcholine transporter (VAChT) antibody, a specific localization of the TLQPp in the motor neurons with a reduction in the pre-symptomatic stage of mutant mice. In conclusion, TLQPp are reduced in the stressed NSC-34 cells, mutant mouse motor neurons as well as in fibroblasts with TARDBP-A382T mutation that also induces production of reactive oxygen specie. Hence, we suggest that their reduction may occur in response to oxidative stress. They could be also considered as early biomarkers, while TLQP-21 acts as neuroprotective factor.
description: Italian Journal of Anatomy and Embryology, Vol. 122, No. 1 (Supplement) 2017