Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma
Creators: name: Southey, M.C.
name: Salles, G.
name: Weinstein, S.
name: Novak, A.J.
name: Holford, T.R.
name: Conde, L.
name: Tinker, L.F.
name: Zelenetz, A.
name: Witzig, T.E.
name: Cerhan, J.R.
name: Boffetta, P.
name: Turner, J.
name: Jackson, R.D.
name: Wang, S.S.
name: Hartge, P.
name: Birmann, B.M.
name: Boeing, H.
name: Monnereau, A.
name: Purdue, M.P.
name: Ramsey-Goldman, R.
name: Clavel, J.
name: Adami, H.-O.
name: Link, B.K.
name: Skibola, C.F.
name: Riby, J.
name: Lan, Q.
name: Klein, R.J.
name: Foretova, L.
name: Ghesquières, H.
name: Severson, R.K.
name: Teras, L.R.
name: Holly, E.A.
name: Giles, G.G.
name: Angelucci, E.
name: Cotenbader, K.H.
name: Tjonneland, A.
name: De Sanjose, S.
name: Zucca, M.
name: Vineis, P.
name: Virtamo, J.
name: Spinelli, J.J.
name: Molina, T.J.
name: Zhang, Y.
name: Kricker, A.
name: Becker, N.
name: Rais, M.
name: Slager, S.L.
name: Severi, G.
name: Lawrence, C.
name: Morton, L.M.
name: Cox, D.G.
name: Wasmann, Y.
name: Zeleniuch-Jacquotte, A.
name: De Roos, A.J.
name: Bracci, P.M.
name: Wang, Z.
name: Tilly, H.
name: Kane, E.
name: Kaaks, R.
name: Di Lollo, S.
name: Bernatsky, S.
name: Clarke, A.E.
name: Glimelius, B.
name: Cozen, W.
name: Ansell, S.M.
name: Zheng, T.
name: Vajdic, C.M.
name: Vermeulen, R.C.H.
name: McKay, J.
name: Brennan, P.
name: Brooks-Wilson, A.R.
name: García, H.A.V.
name: Nieters, A.
name: Gaffney, P.
name: Staines, A.
name: Berndt, S.I.
name: Liebow, M.
name: North, K.E.
name: Roman, E.
name: Benavente, Y.
name: Chanock, S.J.
name: Smith, M.T.
name: Dogan, A.
name: Thompson, C.A.
name: Habermann, T.M.
name: Offit, K.
name: Bertrand, K.A.
name: Maynadie, M.
name: Crouch, S.
name: Kelly, R.S.
name: Melbye, M.
name: Smedby, K.E.
name: Vijai, J.
name: Haioun, C.
name: Albanes, D.
name: Hjalgrim, H.
name: Kraft, P.
name: Smith, A.
name: Diver, W.R.
name: Lightfoot, T.
name: Rothman, N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genomewide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis. Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765. Conclusions: These data suggest several plausible genetic links between DLBCL and SLE.