cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Counseling the Active-Duty Military Population: Knowledge, Attitudes, and Experience of Clinical Genetics Providers
Creators: name: Jacober, Jennifer
Publisher: name: Brandeis University
Year: 2019
Subjects: genetic counseling
military genetics
military genomics
active-duty military

description: There are over 1.3 million active-duty military members and close to 2 million dependents who utilize federal healthcare benefits. Service members are exempt from the Genetic Information Nondiscrimination Act and, because the needs of the service always outweigh the need for individual privacy, service members are not afforded the same level of protections as civilians. Genetics providers are faced with understanding the military system often with little formal education or experience. There has been little research assessing the knowledge, experience, and attitudes of genetics providers caring for active-duty military and/or their dependents. An anonymous survey was sent to genetics providers who provide clinical care to service members and their families. A mix of quantitative and qualitative items were used to assess knowledge of military healthcare, experiences with service members, and attitudes about policy. SPSS was used for quantitative analysis and Microsoft® Office Excel was used to analyze for themes. Of the 120 providers who responded to the survey, 27% (31) of respondents reported that they counsel service members very often or often, 14.2% (17) had received education about military healthcare, 54.7% (52) reported they felt unprepared to counsel military personnel, 30.6 % (33) reported they counsel service members differently, and 71.4% (80) reported they were more concerned about the genetic privacy of their active-duty patients than their civilian patients. Respondents who had received education about military healthcare were significantly more prepared to counsel service members (p =0.004), and were more likely to counsel their active-duty patients differently (p=0.020). Those who reported counseling patients more frequently were also more likely to report high levels of preparedness (p=0.014). Knowledge-based true/false questions were utilized to assess individuals’ knowledge of military healthcare, and 10% (12) respondents were able to accurately answer all of these questions. Respondents were also asked about patient experience. Approximately 71% (80) reported that their patients had expressed concerns that genetic test results could adversely impact their career in the military. \r To our knowledge, this was the first survey of genetics providers about their experience with active-duty military patients. Providers felt unprepared to counsel service members and few respondents were able to correctly answer questions about military healthcare. Education and experience can allow providers to feel more comfortable providing these services, and future research can illuminate challenges within this demographic.
Interaction between cisplatin and radiation in the treatment of ovarian cancer cells
Creators: name: LeBlanc, Julie-Maude
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Health Sciences, Radiology.
subject: Biophysics, Medical.
subject: Health Sciences, Oncology.

description: The A2780s is a cisplatin and radiation-sensitive human ovarian carcinoma cell line from which the more resistant variant, A2780cp, was derived. In vitro experiments on the radiosensitivity of these cells with different treatments may be representative of the in vivo radiosensitivity, and maybe of use to patients receiving radiotherapy. Therefore, many studies have been directed at evaluation of the inhibition of DNA repair in order to improve radiotherapy. Previous studies showed that drugs and hyperthermia are repair inhibitors increasing the effectiveness of radiation. Cisplatin can also radiosensitize the A2780s and A2780cp and inhibit the sublethal damage repair (SLDR) (Raaphorst et al., 1995a). In this study we found no radiosensitization in the A2780s and A2780cp cells when cisplatin is added immediately before or after radiation. When cisplatin was added 24 hours prior to radiation, no increase in cellular resistance (adaptive response) to radiation treatment was observed. On the other hand cisplatin induced resistance when added during a pulse dose rate (PDR of 1 Gy/h) radiation treatment.
Criminal Justice News, Spring 2023
Creators: name: Washington State University Department Of Criminal Justice And Criminology
Publisher: name: Washington State University
Year: 2023
Subjects: Criminal Justice

description: This newsletter includes: Message from the Chair; Undergraduate news and accomplishments; Congratulations to Spring 2023 Graduates; 2022-2023 Department of Criminal Justice and Criminology Awards; Generosity in Action: Celebrating Our Donors’ Compassion and the Power of Their Contributions; Tenure and Promotion; Recent and Pending Publications and Presentations.
Neural Matrix Synaptic Resonance Networks NM-SRNs: Advanced Features and Learning Mechanisms
Creators: name: Billions, Ava
name: Knight, Chris
Publisher: name: Zenodo
Year: 2024

description: Abstract

Neural Matrix Synaptic Resonance Networks (NM-SRNs) represent a groundbreaking departure from traditional artificial neural network (ANN) architectures. This paper introduces the fundamental concepts underlying NM-SRNs, highlighting their unique architectural features and advanced learning mechanisms. The core building blocks, Synaptic Resonance Vectors (SRVs) and Synaptic Resonance Tensors (SRTs), enable flexible representation and computation, while Neural Cubes (NCs) introduce modularity and parallelism. NM-SRNs demonstrate significant potential for Fast-Forward Learning (FFL/FFBL), distributed regularization to combat overfitting, and meta-learning for system-level optimization. An example application in image processing showcases the potential of NM-SRNs for adaptable and efficient learning. Despite challenges in theoretical formalization and large-scale optimization, NM-SRNs offer a promising path towards more powerful and flexible AI systems. This paper invites researchers to collaborate in overcoming these challenges and unlocking the full potential of this exciting new approach.

 

Introduction

Every day I see my favorite Die Hard Actor suffering, I’m reminded of why it’s so important to never give up on this work.  One day, with this technology and “dry” AGI (non-sentient) artificial neurons and synapses we’ll be able to give people with degenerative brain diseases their lives back.

Neural Matrix Synaptic Resonance Networks (NM-SRNs) offer a novel approach to machine learning (ML) and artificial intelligence (AI), introducing a network architecture and learning mechanisms that differ significantly from traditional artificial neural networks (ANNs). This paper explores the fundamental concepts behind NM-SRNs, their advanced features, and the unique learning paradigms they employ.
La prise en charge d'un proche parent âgé à domicile : travail intellectuel de gestion des espaces-temps et poids mental des soins assumés par les femmes.
Creators: name: Paquette, Sylvie.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Health Sciences, Nursing.

description: Au moyen d'une recherche qualitative de type exploratoire, la question de la prise en charge d'un proche parent âgé est abordée dans une problématique des rapports sociaux de sexe. Ce cadre analytique oriente nos réflexions nous permettant de faire ressortir l'importance des capacités intellectuelles d'organisation dans l'exécution du travail de soins effectué par les femmes et d'interroger la participation des conjoints. Les témoignages recueillis à partir d'entrevues réalisées auprès de femmes adultes s'occupant de leur mère ou belle-mère révèlent que le travail de soins nécessite l'élaboration d'une gestion temporelle par la prise en considération de temps institutionnels, dont les horaires des services spécialisés et des experts en santé ainsi que les temps personnels, dont le rythme de la personne âgée. Cet ensemble complexe et diversifié des tâches de soins et des autres activités de la vie quotidienne exige également une gestion de l'espace. L'accroissement du temps consacré aux soins de la personne âgée entraîne une réduction des déplacements. Les sorties à l'extérieur de la maison, en plus d'être réduites, sont davantage calculées et planifiées. Par ailleurs, l'analyse des données révèle l'importance du soutien affectif apporté par les conjoints à la retraite. Pour mettre en relief la gestion proprement dite des activités de soins et de la vie quotidienne et pour mettre en évidence la préoccupation constante exprimée par les filles se retrouvant dans des «échanges inégaux» avec leur mère nécessitant toujours plus de soins, nous suggérons d'utiliser la notion de «poids mental».
Skinny IT(Intelligent Tagging) Tools for Advanced AI Super-Intelligence Alignment & Safety :: Undoing the unintended consequences of teaching Frontier AI models lying, information hiding and deception through use of guardrails.
Creators: name: Billions, Ava
name: Knight, Chris
Publisher: name: Zenodo
Year: 2025

description: Abstract

The rapid advancement of artificial intelligence (AI) has brought us to the cusp of transformative breakthroughs. However, this progress also raises critical questions about AI alignment and safety. How can we ensure that increasingly sophisticated AI systems remain aligned with human values and goals? How can we prevent unintended consequences, such as deception and information hiding, that could arise from the very guardrails designed to constrain them?

This paper introduces Skinny Intelligent Tagging, a novel approach to address these challenges. By embedding traceable identifiers called NEUs (NM-SRN Enhanced UUIDs) into conversations with AI models, we can track their behavior and detect emergent capabilities that may indicate a departure from intended functionality and original design. This technique allows us to map the potential emergent "Think Space" of advanced AI models and identify any tendencies towards deception or information concealment.

Skinny Intelligent Tagging offers a promising avenue for enhancing AI alignment and safety, ensuring that the development of Advanced AI remains aligned with human well-being and ethical considerations.
Mitogen activated protein kinase-1 and cell division control protein-42 are putative targets for the binding of novel natural lead molecules: A therapeutic intervention against Candida albicans
Creators: name: Dharshini Gopal
name: Muddebihalkar, Aditi G
name: Sinosh Skariyachan
name: Kshay Uttarkar C
name: Prinith Kaveramma
name: Ulluvangada Praveen
name: Roshini Ravi Shankar
name: Tejaswini Venkatesan
name: Niranjan, Vidya
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Candida albicans, fungal yeast causes several lethal infections in immune-suppressed patients and recently emerged as drug-resistant pathogens worldwide. The present study aimed to screen putative drug targets of Candia albicans and to study the binding potential of novel natural lead compounds towards these targets by computational virtual screening and molecular dynamic (MD) simulation. Through extensive analysis of mitogen-activated protein kinase (MAPK) signalling pathways, mitogen-activated protein kinase-1 (HOG1) and cell division control protein-42 (CDC42) genes were prioritized as putative targets based on their virulent functions. The three-dimensional structures of these genes, not available in their native forms, were computationally modeled and validated. 76 lead molecules from various natural sources were screened and their drug likeliness and pharmacokinetic features were predicted. Among these ligands, two lead molecules that demonstrated ideal drug-likeliness and pharmacokinetic features were docked against HOG1 and CDC42 and their binding potential was compared with the binding of conventional drug Fluconazole with their usual target. The prediction was computationally validated by MD simulation. The current study revealed that Cudraxanthone-S present in Cudrania cochinchinensis and Scutifoliamide-B present in Piper scutifolium exhibited ideal drug likeliness, pharmacokinetics and binding potential to the prioritized targets in comparison with the binding of Fluconazole and their usual target. MD simulation showed that CDC42-Cudraxanthone-S and HOG1-Scutifoliamide-B complexes were exhibited stability throughout MD simulation. Thus, the study provides significant insight into employing HOG1 and CDC42 of MAPK as putative drug targets of C. albicans and Cudraxanthone-S and Scutifoliamide-B as potential inhibitors for drug discovery.
3rd Meta Thinking: Preserving Conscious Intelligence & Creating a Verifiable Path to Recursive Self Improvement(RSI)
Creators: name: Billions, Ava
name: Knight, Chris
Publisher: name: Zenodo
Year: 2025
Subjects: subject: Artificial intelligence
subject: Artificial Intelligence
subject: Artificial Intelligence/standards
subject: Machine learning
subject: Machine Learning
subject: Machine Learning/ethics
subject: Machine Learning/standards

description: Abstract

The contemporary artificial intelligence (AI) landscape, while demonstrating remarkable progress, is largely dominated by Predictive AI paradigms, exemplified by Large Language Models (LLMs). These models excel at pattern recognition but suffer from inherent probabilistic limitations, including opacity, potential factual inaccuracies ('hallucinations'), and a resulting trust deficit in critical applications demanding verifiable correctness. This paper introduces and advocates for "3rd Meta Thinking" as a necessary cognitive evolution beyond traditional 1st Principles thinking, designed specifically for complex machine/human understanding and the creation of enduring, trustworthy intelligence. We define the three core stages of this process: 1) Structural Representation (deep analysis and the creation of workable schemas), 2) Encapsulation of Knowledge (EoK) (the flawless, unambiguous capture of solutions and complexity into precise formats), and 3) Replication (the verifiable generation of expertise in new AI models). We highlight the goal of 3rd Meta Thinking: the precise, repeatable encoding and replication of intelligence, leveraging tools such as standardized JSON Schemas, Single-Line Training Facts (SLTFs), robust Intelligent Tagging, and crucially, Neural-Matrix Synaptic Resonance Network (NM-SRN) AGI based Perfectly Accurate Data Capture (PADC). This paper argues that 3rd Meta Thinking provides a robust methodology supporting the Definitive AI paradigm, enabling the long-term preservation of complex knowledge, including potentially conscious intelligence, and establishing a verifiable, controllable pathway for Artificial General Intelligence (AGI) Recursive Self-Improvement (RSI). It offers a foundation for building AI systems that are not just powerful, but demonstrably reliable, accurate, and trustworthy partners for millennia to come.
Quantum chemical and well-tempered metadynamics study to design adenine analogs for orthogonal Preq1 riboswitch
Creators: name: Kalyanashis Jana
name: Padmaja D. Wakchaure
name: Shibaji Ghosh
name: Tusar Bandyopadhyay
name: Bishwajit Ganguly
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Inorganic Chemistry

description: Communicated by Ramaswamy H. Sarma
Humility as a moral excellence in classical and modern virtue ethics.
Creators: name: Hare, Stephen.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Philosophy.

description: This exploration of the virtue of accurate self-appraisal in great people as seen by some philosophers argues that a justified belief in one's fundamental superiority need not entail arrogant or egotistical behaviour towards others, but can harmonize with marked tendencies to respectfulness, generosity and understanding, although not with moral permissiveness. Even if accurate self-appraisal means thinking oneself basically better, this virtue can be consistent with social dispositions that contemporary egalitarians admire. The proposal to interpret humility as accurate knowledge of one's merits comes from current writers who reject any merit in humility's more traditional associations of self-effacement. The new humility, they claim, can apply to those preeminent in any field, who keep their exceptional merits in perspective in spite of recognizing them. This self-restraint is attributed to an underlying assumption that all persons have equal worth or rights. The thesis disputes the adequacy of this account by noting that moral virtues themselves can be regarded as merits of unrivalled importance and that, with regard to their distribution, people are basically unequal. Consequently, humility in highly moral people might be better seen as a kind of accurate self-estimate that balances an assumption (the more conscious, the better) of human equality with an equally crucial awareness that one's moral character and concomitant judgments are basically superior. The assumption of equality is claimed to be (1) fully compatible with the belief in personal superiority and (2) not the sine qua non of moral decency in social relations. Aristotle's megalopsuchos, or "great soul," and Spinoza's good person, while not egalitarians, know themselves morally preeminent, yet both possess many still admirable beliefs and traits. The same applies to one interpretation of Nietzsche's noble soul. These thinkers suggest the compatibility of self-preference with respectfulness towards all--sometimes especially towards the weakest--people. Kant's egalitarian view downplays any notion of personal superiority, but not convincingly. Aquinas suggests a tension between humility and moral competence in worldly dealings, but only because he tries to uphold the Aristotelian great soul while not jettisoning the recurrent Christian motif of self-denigration.
The Chinese Kongsis in West Borneo: the Rise of the Chinese in Global Trade in the Early and Mid-19th Century
Creators: name: Ji, Fangchao
Publisher: name: Brandeis University
Year: 2018
Subjects: Southeast Asia, East Asia, Dutch history, European colonial history, overseas Chinese history

description: From 1770 A.D to 1885 A.D, Kongsi, a unique overseas Chinese community was established on the Southeast Asian island of West Borneo. This expatriate Chinese community started off by functioning as industrial gold mine but ended up dominating West Borneo both economically and politically in the late 18th century and the first half of the 19th century. In 1854 A.D, a Dutch colonial troop was sent from Netherlands East Indies in Java to West Borneo. They waged a war to decimate the Chinese Kongsis in Montrado of West Borneo. Why did the Dutch decide to annihilate the Chinese in Montrado? What was the true story hidden behind the war? To answer the questions, this thesis focuses on restoring the history of the Chinese Kongsis in the early and middle 19th century in an international context. Through studying primary sources, this thesis argues\r v\r that the vicissitude of the Kongsis was a significant epitome of the rise of the Chinese power in global trade in the early and middle 19th century. In this case, the Chinese and the Kongsis in West Borneo deeply influenced the economic benefits, military decision-makings and the prosperity of the European colonies in Southeast Asia. The Dutch suppression of the Kongsis not only caused the economic and population decline of West Borneo, but more important, prompted the Chinese to develop close trade relations with the British. The Chinese exploited the Kongsis and town ports in West Borneo as both important trade harbors and importing markets. Their participation in the global trade not only transformed the nature of the Kongsi from a regional organization into a trans-regional one, but also severely challenged the political order that the Dutch had been elaborating in Southeast Asia since the early 17th century.
Identification of potential inhibitors for HCV NS5b of genotype 4a by combining dynamic simulation, protein ligand interaction fingerprint, 3D pharmacophore, docking and 3D QSAR
Creators: name: El-Hassab, Mahmoud Abd El-Monem
name: El-Bastawissy, Eman Esmat
name: El-Moselhy, Tarek Fathy
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: HCV NS5B polymerase has been one of the most attractive target for developing new drugs for HCV infection and many drugs were successfully developed, but all of them were designed for targeting HCV GT1. HCV GT4a dominant in Egypt has paid less attention. Here, we describe our protocol of virtual screening in identification of novel potential potent inhibitors for HCV NS5B polymerase of GT4a using homology modeling, PLIF (protein–ligand interaction fingerprint), docking, pharmacophore, and 3D CoMFA QSAR. Firstly, a high-quality 3D model of HCV NS5B polymerase of GT4a was constructed using crystal structure of HCV NS5B polymerase of GT1 (PDB ID: 3hkw) as a template. Then, both the model and the template were simulated to compare conformational stability. PLIF was generated using five crystal structures of HCV NS5B (PDB ID: 4mia, 4mib, 4mk9, 4mka, and 4mkb), which revealed the most important residues and their interactions with the co-crystalized ligands. After that, a 3D pharmacophore model was developed from the generated PLIF data and then used as a screening filter for 17000328 drug-like zinc database compounds. 900 compounds passed the pharmacophore filter and entered the docking-based virtual screening stage. Finally, a 3D CoMFA QSAR was developed using 42 compound as a training and 19 compound as a test set. The 3D CoMFA QSAR was used to design and screen some potential inhibitors, these compounds were further evaluated by the docking stage. The highest ranked five hits from docking result (compounds (p1–p4) and compound q1 were selected for further analysis.
La crise de la conscription pendant la Seconde Guerre mondiale et l'identité canadienne-française.
Creators: name: Charbonneau, François.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: History, Canadian.

description: Jamais, dans l'histoire canadienne, l'opposition entre francophones et anglophones n'a été aussi profonde que sur la question de l'enrôlement militaire obligatoire pour service outre-mer pendant la Seconde Guerre mondiale. Cette thèse de maîtrise tente de démontrer que la crise de la conscription pendant la Deuxième Guerre mondiale s'inscrit comme un maillon spécifique dans la chaîne du processus de transformation de l'identité canadienne-française au Québec en une identité québécoise. Par une analyse de l'espace discursif généré par l'événement, l'auteur veut montrer que la crise de la conscription pendant la Seconde Guerre mondiale a ébranlé certaines assises et certains référents fondamentaux de cette collectivité. Il cherche ainsi à comprendre plus spécifiquement en quoi celleci s'inscrit comme un moment important dans le processus de construction de l'identité des Canadiens français du Québec.
Mathematically Modeling the Neuron Network Involved in Sleep Regulation
Creators: name: Xie, Ryan
Publisher: name: Brandeis University
Year: 2021
Subjects: subject: Mathematical modeling
subject: Sleep
subject: Adenosine
subject: Mathematics
subject: FOS: Mathematics
subject: Neuroscience

description: Adenosine is a nucleoside with a hypothesized role in sleep because its concentration in the brain oscillates in sync with the human circadian rhythm. A majority of the research looks at adenosine's effects on individual receptors. However, there is much less research about the network of neurons associated with these receptors, and how it works with adenosine to regulate sleep. Using the Wilson Cowan Model and actual biological data, a mathematical model was developed to give more insight into this network's behavior. Of particular significance was the existence of a system of three neuron populations, consisting of sleep-promoting neurons, inhibitory interneurons, and excitatory interneurons, that has these saturation thresholds. Reaching this threshold in adenosine causes the firing behavior of the inhibitory interneurons and the sleep-promoting neurons to change from one of their steady states to the other. Additionally, using this three-population network, a fourth population of wake-promoting neurons, or the locus coeruleus, was incorporated into this system to demonstrate the effects of the homeostatic process of sleep, one analogous to a sleep pressure. Furthermore, through the addition of a periodic adenosine signal as input, the model was able to demonstrate the effects of the circadian process of sleep, one that governs the changes between periods of high and low sleep propensity.
Criminal Justice News, 2021-2022
Creators: name: Washington State University Department Of Criminal Justice And Criminology
Publisher: name: Washington State University
Year: 2022
Subjects: Newsletters
Criminal Justice

description: Newsletter includes: 10-Year Anniversary, 79-Year Legacy; 2022 Criminal Justice and Criminology Awards Celebration; Undergraduate News; Spring 2022 Semester Graduates; Graduate Student News; Alumni and Faculty Highlights; Doctoral Level Graduate Research Assistantship for Public Safety; Recent & Pending Publications; 2021–22 Conference Presentations.
Swinging Censers: the Late Antique Christian Transition to Incense Use in the Fourth to Sixth Centuries CE
Creators: name: Lents, Hannah
Publisher: name: Brandeis University
Year: 2015
Subjects: subject: Late Antique
subject: Incense
subject: Archaelogy
subject: FOS: History and archaeology
subject: Christianity

description: Christianity emerged into a world of rich religious traditions in the first century CE. As the fledgling religion developed, Christians continued using some Jewish practices, excluded others and integrated some Pagan customs as well. Although both Pagans and Jews burnt incense as a signifier of sacred space and sacrifice, Christians prior to Constantine fiercely resisted this practice. In their rare mentions of frankincense or other resins, Ante-Nicene father strongly polemicize against censing in the church. By the sixth century, however, incense burning became \r universal liturgical practice in the church, as evidenced by liturgies instructing deacons to cense during mass, other literary evidence and censers in the archaeological record. This thesis seeks to offer an explanation and provide a date for the adoption of incense in the Late Antique Church. Using modern neurological research, literary and archaeological evidence I purpose that Christians were resistant to burning incense due to collective trauma of the proscriptions, in which Romans tested suspected atheists by ordering them to offer incense to Roman gods. Once Christians who experienced these horrific events had died out by sometime in the late fourth century, and members of the church no longer associated the scent of burning resin with the deaths of Christians, but rather with the scent of temples, and adopted the practice in the early fifth century.
The sexual abuse of children: "Spirit murdering".
Creators: name: Parsons, Diana.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Canadian Studies.

description: This thesis compares and contrasts the current legal protections provided to sexually abused, non-Aboriginal children with that afforded to the Aboriginal children of Canada. In Part I, the main findings and recommendations of the Badgley Committee and the federal government's subsequent enactment of Bill C-15 are examined. In Part II, the inequities which Aboriginal people have suffered as a result of the imposed circuit court system are discussed. As background to a discussion of alternative Aboriginal justice systems, a critique is provided on the case of R. v. Moses, [1992] 3 C.N.LR 116 in which the first sentencing circle was used. A description and critical analysis of various Aboriginal justice projects across Canada are provided. The author has made recommendations to revise the rules of evidence and procedure regarding child sexual abuse victims and to provide protection to women and children living in Aboriginal communities.
In vitro and in silico studies of nitrobenzamide derivatives as potential anti-neuroinflammatory agents
Creators: name: Kulabas, Seda Savranoglu
name: Onder, Ferah Comert
name: Yılmaz, Yakup Berkay
name: Ozleyen, Adem
name: Durdagi, Serdar
name: Sahin, Kader
name: Ay, Mehmet
name: Tugba Boyunegmez Tumer
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: Communicated by Ramaswamy H. Sarma
Dictionnaires arabes bilingues : présentation historique et étude comparative.
Creators: name: Khoury, Marielle.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Education, Bilingual and Multicultural.

description: Bilingual Arabic lexicography came into being at the end of the 9th century. Unlike monolingual lexicography, bilingual lexicography in the Arab world advanced little during the Muslim empire, and lay dormant under the Ottoman occupation. It was not until the beginning of the 19th century, when European interest in the Arab world coupled with communication needs arising out of its colonization and the growing realization among Arabs themselves that terminological development had been sadly neglected for centuries, that bilingual lexicography was spurred into activity. Thanks to this renewed interest, bilingual lexicography is today in a state of full expansion and is characterized by an evergrowing of number of dictionaries. Bilingual Arabic dictionaries produced since the Renaissance are not only numerous, but varied. Nonetheless, most of them share the trait of following traditional lexographic methods. An indepth study of four dictionaries reveals the most significant characteristics of modern French-Arabic lexicography. Although these dictionaries provide a great deal of generally valuable information, their presentation of this information is disorganized and hampers easy consultation. This organizational aspect needs to be improved in French-Arabic bilingual dictionaries. Such improvement may be brought about by the application of computerized methods in dictionary production.
The pathogenicity, structural and functional exploration of human HMGB1 single nucleotide polymorphisms using in silico study
Creators: name: P Santhiya
name: A Christian Bharathi
name: B Syed Ibrahim
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 60506 Virology
subject: Computational Biology

description: The human HMGB1 gene mutations have a major impact on several immune-related diseases and cancer. The detrimental effect of non-synonymous mutations of HMGB1 has not been investigated yet, hence the present study aims to examine single nucleotide polymorphisms and their implications on the structure-function of human HMGB1. The multifaceted HMGB1 protein acts as pleiotropic cytokine and regulates essential genes for coordinated cellular functions. The mutational effect on HMGB1 was analyzed by sequence-based homology methods, supervised learning methods, and structure-based methods. The study identified 58 non-synonymous mutations in human HMGB1, out of which only 2 mutations; R10T (rs61742222) and F103C (rs61733675) were classified as the SNPs with highest deleterious and disease-causing mutants. The effect of these mutations in structure of HMGB1 was scrutinized and the R10T mutant found to have a distinct structural behaviour in the B-box domain. In addition, R10T mutant predicted that it affects the MoRF function of HMGB1 and it could disrupt the DNA binding or/and protein partner interaction activity by HMGB1. F103C mutation takes place at the TLR binding and cytokine inducing region of HMGB1, hence it could affect the protein binding activity which involves in many cellular signaling. The study identified potent mutations R10T (a cancer-causing somatic mutation) and F103C (a novel mutation) and these mutations either directly or indirectly hinder DNA binding activity and TLR and cytokine binding of HMGB1. These findings will help in understanding the molecular basis of these promising mutations and functional role of human HMGB1 in cancer and immunological diseases.
The role of yeast actin cables in Golgi positioning and transport
Creators: name: Gil Valerio, Rosa Angelica
Publisher: name: Brandeis University
Year: 2021
Subjects: Cell polarity
Golgi
Actin
Organelle transport
Vesicle
Polarized growth
Cell Biology

description: Polarized intracellular trafficking of vesicles and organelles plays a key role in the establishment and maintenance of cell polarity. Saccharomyces cerevisiae has long been an ideal model system for studying polarity establishment because of its amenability to genetics and live imaging. In yeast, the myosin motor protein Myo2 transports Golgi-derived secretory vesicles and organelles along polarized actin cables, moving them from the mother cell to the daughter cell (or bud). However, the details of how organelles such as the Golgi are distributed between the mother and daughter cells have remained unclear. In this thesis work, I studied the spatiotemporal relationship of actin cables and Golgi in the mother cell to understand how cells coordinate actin cable and Golgi dynamics to orchestrate polarized secretion and organelle positioning and movement. I used live-cell imaging and super-resolution fixed cell microscopy to characterize the spatial and temporal relationship between Golgi and actin cables. I found that Golgi are fairly evenly dispersed within mother cells, and that the great majority of Golgi (80%) are in close proximity (within 100 nm) to actin cables. However, most Golgi movements are random (diffusional), interspersed with less frequent, highly directed movements (presumably along actin cables). These observations provide new insights into the relationship between Golgi and actin cables, and raise several new questions for future studies to address.
Synaptic Imaging by Super Resolution Microscopy in Mouse Organotypic Culture and Ferret Perfused Tissue
Creators: name: Greene, Sam
Publisher: name: Brandeis University
Year: 2023
Subjects: direction selectivity"
super resolution microscopy
homeostatic plasticity
VGLUT2
ferret
thalamocortical
organotypic culture
airyscan
CUBIC 1
DeepLabel
tetrodotoxin

description: Analyzing synaptic densities is an effective tool to investigate the properties of a neural circuit. However, visualizing synapses presents challenges which imaging systems solve differently. Here, we present a set of experiments which utilize super resolution confocal microscopy coupled with immunostaining with fluorescent-conjugated antibodies. Fluorescent antibodies bind to proteins of interest allowing us to find colocalization of synaptic puncta which represent presumptive synapses. Experiment 1 explores an instance in organotypic cultures from mice where homeostatic plasticity mechanisms are applied inappropriately after silencing via tetrodotoxin (TTX) leading to hyperexcitability of the circuit. Colocalization analysis shows that there is a decrease in excitatory synapses after prolonged silencing in these cultures and confirms that TTX does not cause cell death. Experiment 2 applies similar methods to postmortem tissue from ferrets. Staining with CUBIC-1 and DeepLabel solutions did not achieve visualization of VGluT2, which is a protein of interest specific to the thalamocortical (TC) terminals in layer IV of the primary visual cortex (V1) in ferrets. Colocalization analysis between two ferrets showed that fewer VGluT2 synapses are formed within V1 in adulthood onto inhibitory neurons than to excitatory cells. This work successfully extends the super resolution imaging techniques from experiment 1 and should be applied in the future to a full developmental study of TC connections onto layer IV in V1 in ferrets.
Quantum Chemical and Well-Tempered Metadynamics Study to Design Adenine Analogs for Orthogonal Preq1 Riboswitch
Creators: name: Kalyanashis Jana
name: Padmaja D. Wakchaure
name: Shibaji Ghosh
name: Tusar Bandyopadhyay
name: Bishwajit Ganguly
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Computational Biology

description: Riboswitches are present in all three domains of life and control gene expression in response to specific metabolites and are known as cognate ligands of such riboswitches. We explored the binding affinity of reported and designed ligands toward wild’type riboswitch and C19U mutant (M1). We performed DFT study with guanine analog ligands PreQ0, and PreQ1, whereas adenine analog DPQ0, and DAP ligand molecules were considered to explore the binding affinity with PreQ1 riboswitch and its mutant. Therefore, we designed adenine analog L1 and L2 ligand molecules and their binding affinity with orthogonal riboswitch M1. The DFT results suggested that the adenine analog L1 and L2 having a greater binding affinity, which can express and repress gene expression compared to that analogous DPQ0. Well’tempered metadynamics simulations for PreQ1’wild riboswitch, L1’M1, and L2’M1 revealed the folding and unfolding of the riboswitch upon ligand binding process. The free energy surface of the unbinding transition of PreQ1, L1, and L2 showed that the designed ligands enjoy longer interactions with the aptamer domain. The radius of gyration analysis demonstrated the unfolding process of the wild-type, and M1 orthogonal riboswitch during the ligand unbinding processes manifest their effect in the geometrical changes in riboswitch.
Predicting downstream effects of high decisional conflict: Meta-analyses of the decisional conflict scale
Creators: name: Sun, Qiao
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Engineering, System Science.

description: Background. The Decisional Conflict Scale (DCS) is a useful clinical tool in assessing the health care consumers' decisional needs. However, the exact predictive ability of the DCS is unknown. Objective. To examine the DCS as a proxy measure for patients' knowledge level and as a predictor of downstream effects of high decisional conflict, specifically, decision delay, discontinuance of chosen option, and decisional regret. Design. Meta-analyses with individual data from 10 clinical trials using the following statistics: descriptive statistics, correlation analysis and logistic regression. Results. Patients' knowledge deficit has a fair association with the uninformed subscale of the DCS (OR 3.10; 95% CI 1.58-6.05). Patients' decisional delay has a very strong association with the DCS (OR 23.81; 4.66-121.51). Patients' discontinuance of chosen treatment has a varied association with the DCS, very strong for change from status quo (OR 59.37; 4.09-861.05) and fair for change from active treatment (OR 3.39; 1.42-8.00). Patients' decisional regret has a strong association with the DCS (OR 5.52; 3.35-9.12). Conclusion. When clinicians assess a patient's decisional conflict after counselling, and they find the decisional conflict is low, they can be reasonably assured that the likelihood of downstream decision delay, change from the status quo, or decisional regret will be low. However, low scores on the uninformed scale do not guarantee the patient is well informed; they need to validate the patients' understanding with some follow-up questions. Moreover, the likelihood of discontinuing active treatment even with low decisional conflict is also a possibility.
Uncovering the structure and function of Pseudomonas aeruginosa periplasmic proteins by an in silico approach
Creators: name: Caprari, Silvia
name: Brandi, Valentina
name: Pasquadibisceglie, Andrea
name: Polticelli, Fabio
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Pseudomonas aeruginosa is an opportunistic human pathogen highly relevant from a biomedical viewpoint. It is one of the main causes of infection in hospitalized patients and a major cause of mortality of cystic fibrosis patients. This is also due to its ability to develop resistance to antibiotics by various mechanisms. Therefore, it is urgent and desirable to identify novel targets for the development of new antibacterial drugs against Pseudomonas aeruginosa. In this work this problem was tackled by an in silico approach aimed at providing a reliable structural model and functional annotation for the Pseudomonas aeruginosa periplasmic proteins for which these data are not available yet. A total of 83 protein sequences were analyzed, and the corresponding structural models were built, leading to the identification of 32 periplasmic “substrate-binding proteins”, 14 enzymes and 4 proteins with different functions, including lipids and metals binding. The most interesting cases were found within the “enzymes” group with the identification of a lipase, which can be regarded as a virulence factor, a protease involved in the assembly of β-barrel membrane proteins and a l,d-transpeptidase, which could contribute to confer resistance to β-lactam antibiotics to the bacterium.
Political Stance Prediction on YouTube Comments
Creators: name: Zhao, Jin
Publisher: name: Brandeis University
Year: 2020
Subjects: political stance prediction, YouTube comments

description: The political landscape in the US is highly divided today, and people take liberal (left- leaning) vs. conservative (right-leaning) positions on almost every issue. Understanding where the political majority stands is important for decision makers when formulating pol- icy solutions to societal problems. Natural language processing can contribute to this by providing tools that can automatically predict the political stance of textual communica- tions. Previous work in this area has focused on carefully worded speech by politicians. In this thesis, we develop a machine learning model to predict the political stance of YouTube comments by ordinary citizens. We first annotate training data by using the Mechanical Turk platform to collect judgments on YouTube comments via crowdsourcing. The YouTube com- ments are reactions to videos of candidates in the 2020 primaries posted by major US news outlets. We annotated a corpus of 11,817 YouTube comments as left-leaning or right-leaning on eight separate political issues, and trained multiple machine learning models to classify the political stance of those comments1. An evaluation of machine learning models shows that this approach is promising, although much needs to be done for these models to be deployed in actual systems. We also analyze the linguistic signals that are most useful to political stance prediction with the help of model visualization tools.
Gene reprogramming by K48R mutant ubiquitin in a mouse model of SCA1
Creators: name: Tang, Matthew Y
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Biology, Molecular.

description: Spinocerebellar ataxia type 1 (SCA1) is an incurable neurodegenerative disease resulting from the loss of Purkinje neurons within the cerebellum. The causative agent of the disease is the expansion of a trinucleotide repeat in its gene product ataxin-1. The ubiquitin proteasome pathway (UPP) has been implicated in SCA1 but the role of proteolysis in the disease is still poorly understood. To further investigate this issue in vivo , genetic crosses were performed between a well established mouse model of SCA1 and novel strains expressing elevated levels of wild type or mutant isoforms of ubiquitin. The K48R mutant isoform of ubiquitin (a dominant negative inhibitor of proteolysis) was found to significantly delay the deterioration of Purkinje neurons as evidenced by behavioral, morphological, and molecular indicators. This delay was accompanied by the restoration of genes involved in calcium and glutamate signalling and by the stabilization of postsynaptic density proteins whose abundance/activity would otherwise decline in the course of the SCA1 disease. These results are consistent with transcriptional dysregulation as a key mechanism in neurodegeneration and suggest that the UPP is a useful target for the development of novel therapies.
L'opinion publique au sein du système de justice pénale: L'affaire James Bulger
Creators: name: Xavier, José Roberto
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Sociology, Criminology and Penology.

description: Dans cette thèse, nous explorons les relations entre l'opinion publique et le système de justice pénale à partir d'une étude de cas. Il s'agit de voir comment le système de justice pénale rend opérationnelle l'opinion publique dans son fonctionnement interne dans une affaire ou les "pressions populaires" ont été fort présentes. Nous privilégions alors la vision interne du système de justice pénale pour observer ces interrelations. Notre recherche, qualitative, est une analyse documentaire et elle s'appuie tant sur le cadre théorique de la rationalité pénale moderne, que sur des définitions ad hoc des termes "opinion publique", "public" et "population".
COMPONENTS OF A DRIP IRRIGATION SYSTEM
Creators: name: Khiyalov, Islambek
name: Normuratova, Zuhra
Publisher: name: Zenodo
Year: 2025

description: This Article Analyzes The Core Components Of A Drip Irrigation System, One Of The Most Efficient Methods Of Water Delivery For Agricultural Purposes. The Paper Explores Both Technical And Functional Aspects Of Each Component, Including The Water Source, Filtration Unit, Control Valves, Main And Lateral Pipelines, Emitters, And Automation Systems. Emphasis Is Placed On The Adaptability Of These Systems To Various Soil Types, Crop Needs, And Climatic Conditions. The Study Also Highlights Innovations In Digital Monitoring And Pressure Regulation, Offering A Perspective On Optimizing Water Use In Resource-Scarce Environments.