cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Alberta Gambling Research Institute Conference 2023: Contemporary Issues in Gambling Research
Creators: name: Allami, Yousseff
name: Bedford, Kate
name: Hodgins, David
name: Indige-Spheres Youth Group
name: Kim, Andrew
name: Manitowabi, Darrel
name: McGrath, Dan
name: Naraine, Michael
name: Newall, Philip
name: Nicoll, Fiona
name: Shaw, Carrie
name: Stevens, Rhys
name: Volberg, Rachel
name: Williams, Robert
name: Busenius, Andree
name: Gordon, Ted
name: Krutz, Jonathan
name: Lee, Bonnie
name: Lloyd, Joanne
name: McLuhan, Arthur
name: Stark, Sasha
name: Supan, Savannah
name: Matheson, Flora
name: Ford, Madison
name: Papineau, Elisabeth
Publisher: name: Alberta Gambling Research Institute
Year: 2023

description: The Institute’s 2023 Conference "Contemporary Issues in Gambling Research" took place March 30 to April 1, 2023 at The Banff Centre in Banff, Alberta as a hybrid live and virtual event. A selection of conference presentations presented at the event have been made available with the permission of the authors.
On Weak Odd Domination and Graph-based Quantum Secret Sharing
Creators: name: Gravier, Sylvain
name: Javelle, Jérôme
name: Mhalla, Mehdi
name: Perdrix, Simon
Publisher: name: arXiv
Year: 2011
Subjects: subject: Computational Complexity (cs.CC)
subject: Quantum Physics (quant-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: A weak odd dominated (WOD) set in a graph is a subset B of vertices for which there exists a distinct set of vertices C such that every vertex in B has an odd number of neighbors in C. We point out the connections of weak odd domination with odd domination, [sigma,rho]-domination, and perfect codes. We introduce bounds on κ(G), the maximum size of WOD sets of a graph G, and on κ'(G), the minimum size of non WOD sets of G. Moreover, we prove that the corresponding decision problems are NP-complete. The study of weak odd domination is mainly motivated by the design of graph-based quantum secret sharing protocols: a graph G of order n corresponds to a secret sharing protocol which threshold is κ_Q(G) = max(κ(G), n-κ'(G)). These graph-based protocols are very promising in terms of physical implementation, however all such graph-based protocols studied in the literature have quasi-unanimity thresholds (i.e. κ_Q(G)=n-o(n) where n is the order of the graph G underlying the protocol). In this paper, we show using probabilistic methods, the existence of graphs with smaller κ_Q (i.e. κ_Q(G)< 0.811n where n is the order of G). We also prove that deciding for a given graph G whether κ_Q(G)< k is NP-complete, which means that one cannot efficiently double check that a graph randomly generated has actually a κ_Q smaller than 0.811n.
description: Subsumes arXiv:1109.6181: Optimal accessing and non-accessing structures for graph protocols
A Spotlight on Recent Developments in Diagnosis and Treatment of Cholesteatoma
Creators: name: Rajamani, Santhosh Kumar
Publisher: name: figshare
Year: 2023
Subjects: Otorhinolaryngology

description: In 1838, when Johannes Müller first described Cholesteatoma,
 he thought that it was a tumour of the fatty tissue, (Latin: steat=fat). The reported annual incidence of Cholesteatoma worldwide is around 10 per 100,000. There have been reports of association between cholesteatoma and pediatric progressive sensorineural hearing loss [1]. Cholesteatoma ears show reduced microbial diversity with predominance gram positive cocci Staphylococcus aureus. Staph aureus cocci are associated with a progressive form of Cholesteatoma [2].
Reconstructing opacity. Husserlian motivation as a ‘third synthesis’
Creators: name: Dell'Orto, Francesca
Publisher: name: Lebenswelt. Aesthetics and philosophy of experience.
Year: 2011

description: In this article I propose to read the Husserlian notion of ‘motivation’ by comparison with the Kantian Schematism, in order to understand its peculiar status and time frame. I maintain that motivations – like a third synthesis in addition to retention (perception) and recollection (reproduction) – mediate and organize the flux of retentions and protentions by intercession of external supports (material, artificial and cultural). Thus, they offer the means to thematize history and, consequently, to recast the transcendental basis of Phenomenology taking the opacity of consciousness into serious account.
description: Lebenswelt. Aesthetics and philosophy of experience., No 1 (2011)
Killing Horizons as Equipotential Hypersurfaces
Creators: name: Smolić, Ivica
Publisher: name: arXiv
Year: 2012
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this note we present a new proof that Killing horizons are equipotential hypersurfaces for the electric and the magnetic scalar potential, that makes no use of gravitational field equations or the assumption about the existence of bifurcation surface.
description: 8 pages; revised, published version; several assumptions removed from the final theorem
De la méconnaissance
Creators: name: Dumouchel, Paul
Publisher: name: Lebenswelt. Aesthetics and philosophy of experience.
Year: 2011

description: I argue that the conception of «méconnaissance» put forward by René Girard should be understood in relation to what Popper calls objective knowledge rather than to the classical idea of knowledge as true and justified belief. Objective knowledge considers knowledge as a tool which is open to many uses and abuses. It allows us to make sense of Girard’s claim that «méconnaissance» grows as our knowledge increases and shows that knowledge and «méconnaissance» should not be understood as polar opposites. This suggests a different relationship between «méconnaissance» and revelation, that revelation does not spell the end of «méconnaissance» but rather initiates a different type of relationship between knowledge and «méconnaissance». I try to illustrate this last point with the help of two examples: Ernesto De Martino’s analysis of tarantism in La terra del rimorso and John Rawls’s idea of a veil of ignorance in his A theory of justice.
description: Lebenswelt. Aesthetics and philosophy of experience., No 1 (2011)
Identification and characterization of a J-domain containing protein as a novel co-modifier of Self-incompatibility response in Brassica napus
Creators: name: Kumar, Abhinandan
Publisher: name: Science
Year: 2021
Subjects: subject: Self-incompatibility (SI)
subject: S-locus
subject: Brassicaceae
subject: SCR/SP11
subject: HSP-40
subject: ARC1
subject: E3 ligase
subject: JDP1
subject: ubiquitination
subject: CRISPR-Cas9
subject: Brassica napus
subject: protein interaction
subject: GLO1
subject: EXO70A1
subject: Biology--Molecular
subject: Biology--Genetics
subject: Biology--Plant Physiology

description: Self-incompatibility (SI) is a mechanism that plants utilize to prevent inbreeding and promote outcrossing. In Brassicaceae, this is a genetic mechanism that is controlled by S-locus in which haplotype-specific rejection of self-pollen is achieved through recognition of the pollen ligand SCR/SP11 by the S-receptor kinase of the papillary cells. The receptor-ligand activation converges on an E3 ligase, ARC1, which targets degradation of compatibility factors that result in blocking of delivery of resources required for pollen germination, leading to SI response. In this thesis, I have used the CRISPR-Cas9 gene editing platform to confirm the role of ARC1 during SI signaling and have also identified JDP1 as an interactor and modifier of ARC1, required for full manifestation of SI response.The role of ARC1 in the self-incompatibility pathway in Brassicaceae has remained a point of contention within the scientific community for over 20 years. Through gene-editing to create loss-of-function of alleles of ARC1 in Brassica napus, I was able to show that loss of ARC1 resulted in complete breakdown of SI in two different haplotype combinations proving the necessity of ARC1 for successful manifestation of SI.I next explored whether there are other positive regulators of SI at or downstream of ARC1 through a cytosolic interaction assay that identified J-domain containing protein (JDP1) as a potential cytosolic interactor of ARC1. This HSP-40 family protein interacted with ARC1 only when Tyr8 was modified or absent suggesting likely post-translational in-vivo regulation of this Tyr8 of JDP1. Through transgenic approaches to suppress JDP1, I was able to demonstrate that JDP1 is a positive regulator of SI and overexpression of the JDPY8F form led to constitutive rejection response irrespective of upstream signals demonstrating that the ARC1 interacting JDPY8F was sufficient to confer SI response.Further biochemical characterization of JDP1 revealed that the X-domain of JDP1 which is necessary for binding ARC1, harbored E3 ligase activity. Both JDPY8F and JDP?J (X-domain) were able to enhance ARC1-dependent ubiquitination of previously identified ARC1 substrates GLO1 and EXO70A1 suggesting that interaction of ARC1 with Tyr8 modified JDP1 may be essential for full functionality of ARC1.
Catholicism and cohabitation in Canada : a multi-religious assessment of Cornwall’s determinants of religious behavior model.
Creators: name: Kaufmann Sotomayor, Maria Eugenia
Publisher: name: University of British Columbia
Year: 2013

description: This paper examines the relationship between belief and behavior as seen in the association between Catholicism and cohabitation in Canada. It analyzes whether belief in the Catholic Church's teachings about sexuality and family life influences parishioners propensity not to cohabit to a greater extent than Protestant and secular (no religion) beliefs. Employing Cornwall's Determinants of Religious Behavior Model and data from the 2010 Canadian General Social Survey (Cycle 24: Time-Stress and Well-Being), it was expected that the results would indicate that belief in the Catholic Church's teachings about sexuality and family life influences parishioners propensity not to cohabit to a greater extent than beliefs in Protestant and secular (no religion) doctrines in Canada. That is, belief in the Catholic Church's teachings about sexuality and family life was expected to decrease the likelihood of cohabitation when compared with less resolute Protestant sects and secular (no religion) beliefs. The findings largely support Cornwall’s model, however no support was found for the expectation that Catholics would exhibit lower rates of cohabitation compared to Protestants and those who do not affiliate with a religion.
Transparency and the logic of auto-immunity
Creators: name: Antonelli, Emanuele
Publisher: name: Lebenswelt. Aesthetics and philosophy of experience.
Year: 2011

description: In Voyous, Jacques Derrida develops his argument starting from the presupposition that democracy as such is the entity whose integrity and immunity are at stake and, therefore, under investigation. This gesture reflects the setting in which ten years before, in Foi et savoir, he had cast his reasoning about the logic of immunity. There, it was one of the sources of religion, the immunity of the sacred, that operated according to this logic. The hyphen between these two essays, beside Derrida’s own crossed references, is the genealogical reasoning on the meaning and essence of the concept of democracy: contrary to what Derrida claims, it will be maintained that Athenian democracy had a clear immune matrix, whose constant exercise is clearly defined, in spite of himself, by Vernant, and it will be shown how modern democracy has been forced to change policy. Modern democracy is an entity characterized by an immune deficiency. In order to save Derrida’s intuition from both the collapse of different vantage points and from a quite bizarre reticence in taking into account of the immune value of rituals, our starting point will be René Girard’s œuvre and his reading of the role of immune logic in sacred systems and, more generally, in modernity. The threshold between the auto-immune reaction, immune deficiency and auto-immune disease, between the sacrifice who delimits and constitutes the self and the holocauste du peuple en détail, is the space where, constantly exposed to the risk of auto-denial, democracy lives.
description: Lebenswelt. Aesthetics and philosophy of experience., No 1 (2011)
Development, characterization and creep resistance of cubic zirconia doped with rare earth oxides processed through spark plasma sintering
Creators: name: Robles Arellano, Karen Denisse
Publisher: name: University of British Columbia
Year: 2013

description: Development of new technological systems, such as fuel cells or nuclear power generation stations, often relies on the availability of materials whose properties accommodate the operational requirements of the system. Fabrication of creep-resistant ceramic materials is currently receiving worldwide interest due to their potential use in solid oxide fuel cells, thermal barrier coatings and insulators for hostile environments. In this research a novel fabrication process, Spark Plasma Sintering (SPS), was used to prepare cubic Yttria-stabilized Zirconia (YSZ) composites doped with three different rare earth oxides. Specifically, YSZ was doped with 6.4wt%, 12.7 wt% and 18.8 wt% CeO₂; 11.6 wt%, 21.6 wt% and 30.5wt% La₂O₃; and 12wt% and 22 wt% Nd₂O₃. Composites were successfully fabricated using the SPS technique, and the effect of selected parameters on density and grain size was studied. The novel composites were characterized using Scanning Electron Microscope –X-Ray Energy Dispersive Spectroscopy (SEM-XEDS), X-Ray Diffraction (XRD) and Optical Microscopy (OM). Also, compressive creep testing was performed and the active creep deformation mechanisms were studied. The results reveal that increasing the sintering temperature resulted in grain growth in all the composites. Addition of the rare earth oxides had a strong grain refinement effect on YSZ. Further, addition of La₂O₃ and Nd₂O₃ resulted in formation of a bimodal microstructure. In contrast, the effect of variation of dopant wt% on the grain size and relative density of the composites could not be established. Compressive creep tests in the temperature range of 1200-1330°C were carried out for YSZ, 6.4wt% CeO₂–YSZ and 11.6wt% La₂O₃ –YSZ composites. The stress exponent for all composites ranged between 1.2-2.7. The activation energy was ~730 kJ/mol for YSZ, ~490 kJ/mol for 6.4wt% CeO₂–YSZ and ~566 kJ/mol for 11.6wt% La₂O₃ –YSZ. These values of n and Q suggest that creep deformation was primarily accommodated by grain boundary sliding possibly assisted by lattice diffusion. These results were supported by microstructure evaluation, where evidence of grain boundary sliding was observed as crenellated cracks along boundaries, as well as grain boundary cavitation. There was a potential stress-induced phase transformation in the YSZ material, possibly related to the metastable t’ or monoclinic phases.
BLACKBERRY SEED OIL-LOADED PLA NANOFIBERS AS ACTIVE PACKAGING WITH UV ABSORBENT POTENTIAL
Creators: name: Miletić, Aleksandra
name: Matović, Ljiljana
name: Karlovits, Igor
name: Pilić, Branka
Publisher: name: Zenodo
Year: 2021

description: Abstract: It is well-known that waste originating from food production can be a valuable raw material rich in active components. Concerning the latest trends in the circular economy, a waste-less economy with zero environmental impact, revalorization of the waste is highly recommended. Waste generation is very high in the industry of natural beverages since fruits and vegetables are pressed, and the amount of pomace leftover is enormous. These pomaces can be dried and further processed to extract valuable components, mainly antioxidants, used in food, cosmetics, packaging, etc. Cold-pressed blackberry seed oil (BSO) is a precious component derived from the dried seeds left from juice production. It has a high antioxidant content and high chlorophyll content (around 3000 mg/kg). It is rich in omega fatty acids, vitamins E and C, and has a very high carotenoids content (35-40 mg/kg). BSO has excellent UV absorption power and can be used in sunscreens. UV light can trigger chemical reactions that can produce free radicals and auto-oxidation of lipid-rich food, which can cause the change of the food quality and might induce the deterioration and discoloration of fresh meat, degradation of vitamins, and the development of off-flavors. In order to minimize the effect of UV irradiation on food quality, different UV filters and absorbers can be used, which can be incorporated into the packaging material. There are organic (benzophenones and benzotriazoles) and inorganic (titanium dioxide and zinc oxide) UV absorbers commonly used in food packaging. PLA-based nanofibrous films were prepared by loading an appropriate amount of BSO with potential use as UV absorbent packaging. Materials were characterized using mechanical, thermal, morphological, chemical, and application properties. The presence of BSO did not affect the properties of PLA when compared to pure PLA nanofibers, and material made this way can be successfully used as active packaging material for light-sensitive food.
Andreev reflection from a topological superconductor with chiral symmetry
Creators: name: Diez, M.
name: Dahlhaus, J. P.
name: Wimmer, M.
name: Beenakker, C. W. J.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: It was pointed out by Tewari and Sau that chiral symmetry (H -> -H if e h) of the Hamiltonian of electron-hole (e-h) excitations in an N-mode superconducting wire is associated with a topological quantum number Q\in\mathbb{Z} (symmetry class BDI). Here we show that Q=Tr(r_{he}) equals the trace of the matrix of Andreev reflection amplitudes, providing a link with the electrical conductance G. We derive G=(2e^2/h)|Q| for |Q|=N,N-1, and more generally provide a Q-dependent upper and lower bound on G. We calculate the probability distribution P(G) for chaotic scattering, in the circular ensemble of random-matrix theory, to obtain the Q-dependence of weak localization and mesoscopic conductance fluctuations. We investigate the effects of chiral symmetry breaking by spin-orbit coupling of the transverse momentum (causing a class BDI-to-D crossover), in a model of a disordered semiconductor nanowire with induced superconductivity. For wire widths less than the spin-orbit coupling length, the conductance as a function of chemical potential can show a sequence of 2e^2/h steps - insensitive to disorder.
description: 10 pages, 5 figures. Corrected typo (missing square root) in equations A13 and A14
Generalizability of the Dual Vulnerability Model to Age-modified Risk Factors of Depression
Creators: name: Lukmanji, Aysha
Publisher: name: Science
Year: 2021
Subjects: subject: Depression, Epidemiology, Psychiatry
subject: Health Sciences--Epidemiology
subject: Cognitive
subject: Physiological

description: Background: The association between seasonality and depression has been demonstrated to decrease with age. This age modification has also been observed between seasonal changes and nine depressive symptoms as hypothesized by the Dual Vulnerability Model. This model posits that due to seasonal changes certain individuals have a biological vulnerability to develop somatic symptoms, and of individuals with this biological vulnerability a smaller subset will have a cognitive vulnerability. These individuals will then develop affective symptoms and consequently depression. The first objective of this study is to determine a set of risk factors for depression that exhibit age modification. The second objective is to determine if modification by age, in situations where risk factors show stronger effects in young people, is aligned with the DVM.Methods: Cross-sectional data from the Canadian Community Health Survey was used for analysis. Logistic regression was used to assess age modification in the association between 10 risk factors and depression as measured by the Patient Health Questionnaire-9 (PHQ-9). Then, logistic regression analysis was used to determine if there was an age-modified association between risk factors and symptoms of depression as measured by each item of the PHQ-9. This symptom-specific analysis was only conducted for risk factors that exhibited an age-modified association with depression overall.Results: Only sex and binge drinking exhibited age modification with overall depressive symptoms, where the association declined with age. For sex, symptoms of feeling depressed, poor/enhanced appetite, and low self-esteem exhibited age modification. For binge drinking, symptoms of feeling tired and appetite changes exhibited age modification. The association between binge drinking or sex with these symptoms was stronger in adolescents and young adults and diminished with age. Conclusions: The age modification for sex and binge drinking did not align with the DVM suggesting that the DVM may be a somewhat specific characteristic of seasonal depression.
Quantum adiabatic theorem in light of the Marzlin-Sanders inconsistency
Creators: name: Ortigoso, Juan
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: A consensus that questions the perfunctory use of the quantum adiabatic theorem has emerged since Marzlin and Sanders [Phys. Rev. Lett. {\bf 93}, 160408 (2004)] showed the existence of an inconsistency in the applicability of the theorem. Further analysis proved that the inconsistency may arise from the existence of resonant terms in the Hamiltonian, but recent work indicates that the debate about the full extent of the problem remains open. Here, we first show that key premises required in the standard demonstration of the theorem do not hold for a dual Hamiltonian involved in the Marzlin-Sanders inconsistency. Also, we show that two simple conditions can identify systems for which the adiabatic approximation fails, in spite of satisfying traditional quantitative conditions that were believed to guarantee its validity. Finally, we prove that the inconsistency only arises for Hamiltonians that contain resonant terms whose amplitudes go asymptotically to zero.
description: Published version. It contains some changes with respect to previous versions
Virtual Exploration through a Philosophical Tool
Creators: name: Kwon, Dohyun
Publisher: name: Schulich School of Engineering
Year: 2021
Subjects: subject: VR Technolgy
subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: Artificial Intelligence
subject: Engineering--Petroleum
subject: Computer Science

description: As the era of big data emerges with digitalized devices, innovative data storage systems, and instant access to data, big data analysis technology has become a ubiquitous tool in our life opening up possibilities to resolve problems in various industries, services, and disciplines and experience our existence richly. However, in the era of big data, as technology evolves rapidly and becomes complicated and sophisticated to deal with big data, technology has been difficult for humans to understand and utilize it to analyze, interpret, and interact with data. This imbalanced phase between development of technology and the alienation of humans from technology is shrinking the possibilities rather than expanding. To reconcile technology and data with humans and transform technology into a mediator, this research presents a) a philosophical framework that mediates between technology, humans, and data in the form of an interactive exploration pipeline, b) a self-explanatory virtual reality (VR) application system, and c) an immersive human-centered VR environment for problem-solving and cognitive tasks. To discover, identify, and provide new possibilities of applying the philosophical framework to human-computer interaction, we conduct exploratory evaluations on the VR environment. Built upon reflections on the evaluation results, this thesis ends with a remark of a potential impact of this thesis on future exploration in VR research.
A New Analysis Method for WIMP searches with Dual-Phase Liquid Xe TPCs
Creators: name: Arisaka, K.
name: Beltrame, P.
name: Ghag, C.
name: Lung, K.
name: Scovell, P. R.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: A new data analysis method based on physical observables for WIMP dark matter searches with noble liquid Xe dual-phase TPCs is presented. Traditionally, the nuclear recoil energy from a scatter in the liquid target has been estimated by means of the initial prompt scintillation light (S1) produced at the interaction vertex. The ionization charge (C2), or its secondary scintillation (S2), is combined with the primary scintillation in Log(S2/S1) vs. S1 only as a discrimination parameter against electron recoil background. Arguments in favor of C2 as the more reliable nuclear recoil energy estimator than S1 are presented. The new phase space of Log(S1/C2) vs. C2 is introduced as more efficient for nuclear recoil acceptance and exhibiting superior energy resolution. This is achieved without compromising the discrimination power of the LXe TPC, nor its 3D event reconstruction and fiducialization capability, as is the case for analyses that exploit only the ionization channel. Finally, the concept of two independent energy estimators for background rejection is presented: E2 as the primary (based on C2) and E1 as the secondary (based on S1). Log(E1/E2) vs. E2 is shown to be the most appropriate phase space in which to evaluate WIMP signal candidates.
Defining an Epigenetic Role for the Peptidylarginine Deiminases at the Feto-Maternal Interface
Creators: name: Bering, Elizabeth A.
Publisher: name: Cumming School of Medicine
Year: 2021
Subjects: subject: Stem cells
subject: Epigenetics
subject: Histone Code
subject: Trophoblast
subject: Citrulline
subject: Placenta
subject: Biology--Genetics
subject: Biology--Molecular

description: The epigenome bestows an interpretive layer to the genome that provides instructions as to which genes may be transcribed by the cell. As such, epigenetic modifications underpin the critical first cell lineage separation in the early embryo and orchestrate further differentiation of cells throughout development. While certain epigenetic modifications such as histone methylation are better-understood, other modifications such as histone citrullination and its conferring enzyme family, the peptidylarginine deiminases (PADIs), are relatively unexplored, particularly in a developmental context. Recent work has illuminated the importance of the PADI4 protein in the first cell fate decision and the maintenance of embryonic stem cell (ESC) pluripotency. However, the role of the PADIs and histone citrullination in trophoblast stem cells (TSCs) remains unknown. TSCs are the precursor cells of the major placental structures and represent the extraembryonic counterpart to ESCs. As such, the focus of this project was to produce the first in-depth characterization of the expression and function of the Padi genes and their epigenetic mark histone citrulline in murine TSCs. In this thesis, I report on several novel findings, including the expression of Padi2, Padi3, and Padi4 in TSCs, which is highest in the stem cell condition and decreases upon differentiation. Additionally, I identify the accumulation of histone H3 citrulline at chromocenters and its association with other epigenetic repressive marks, such as the KAP1 protein and H3K9me3. I also present the first Padi gene knockout (KO) study in TSCs with the generation of Padi2, Padi3, and Padi4 KOs and a Padi2/3 double KO. While the phenotypic analysis of these KOs revealed subtle changes like decreased proliferation and increased nuclear size, a readout of differentiation in trophoblast cells, none of the KOs cause an overt exit from the stem cell state. Notably, gene expression analysis via RNA-seq illustrated an apparent loss of heterogeneity amongst KO clones compared to the wild-type (WT), indicating a reduction of the plasticity required of multipotent stem cells in these KOs. Moreover, individual KOs had distinct effects on transcriptional profiles, highlighting the unique, non-redundant roles of the PADI proteins in TSCs. Finally, my work illustrates a nuclear role for PADI3, which has previously not been reported. I also identify Padi3 as a potential TSC marker gene which may possess a role in the earliest lineage separation in the blastocyst. Altogether this work provides new insights into the function of the PADIs and histone citrullination in a developmental context.
Dynamics of Colloids at Liquid-liquid Interface: Insights from Mesoscale and Microscale Simulations
Creators: name: Hossain, Mohammad Tanvir
Publisher: name: Schulich School of Engineering
Year: 2022
Subjects: subject: Diffusion
subject: Nanoparticle
subject: Interfacial phenomena
subject: Microrheology
subject: Janus particle
subject: Soft matter
subject: Dissipative particle dynamics
subject: Langevin dynamics.
subject: Physical Sciences
subject: Biological Sciences

description: The dynamics of a colloidal particle at a liquid-liquid interface play an important role in several processessuch as microrheology, Pickering emulsion, encapsulation, biofilm formation. Their behaviour at the interfaceis completely different from the bulk. Moreover, due to complexity of hydrodynamics and the effectof contact lines make this study more challenging. In addition to that Janus type colloids which have multiplesurface characteristics and shapes introduce another degree of complexity. For example, amphiphilicJanus nanoparticles exhibit higher interfacial activity and adsorb more strongly to fluid interfaces than homogeneousnanoparticles of similar sizes. Both shape and chemical anisotropy on the same particle, Janusparticles offer rich self-assembly possibilities for nanotechnology. Despite their strong interest, the interfacialbehaviour of colloid nanoparticles is not fully exposed.In this thesis, a detailed analysis of dynamics for homogeneous and Janus particle varying their size andlocation at the interface has been provided. To perform that two different approaches have been considerednamed Langevin dynamics(LD) and Dissipative Particle Dynamic (DPD). In LD where the surface force andcontact line fluctuation are considered through an analytical solution where DPD is solved only based onthe interaction between particles.Finally, by using dissipative particle dynamics simulation, the translational diffusion of Janus nanorods atthe interface between two immiscible fluids is investigated. The particle aspect ratio affects both particle’stranslational thermal motion and the average orientation of the particle with respect to the interface atequilibrium. This behaviour is also linked to the interfacial tension of the system.Findings from this research will provide fundamental insights into the dynamics and self-assembly of isotropicand anisotropic Brownian particles at interfaces.
title: Plaque characterization on CTA images as a prognostic factor of cerebral ischaemia in patients with significant carotid artery stenosis
Creators: name: Panajotu, Alexisz
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Arteries / Aorta
subject: Vascular
subject: CT-Angiography
subject: MR
subject: Image manipulation / Reconstruction
subject: Segmentation
subject: Surgery
subject: Arteriosclerosis
subject: Ischaemia / Infarction

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The reconstruction of internal carotid artery (ICA) stenosis is an effective method to reduce stroke risk. The indication for surgery is the presence of a significant grade ICA diameter stenosis (above 70%). According to the international literature...
Benzylisoquinoline Alkaloid Biosynthesis in Sacred Lotus (Nelumbo nucifera)
Creators: name: Menendez Perdomo, Ivette M.
Publisher: name: Science
Year: 2022
Subjects: subject: Nelumbo nucifera
subject: benzylisoquinoline alkaloids
subject: norcoclaurine synthase
subject: proaporphine synthase
subject: bisbenzylisoquinoline synthase
subject: methylenedioxybridge synthase
subject: methyltransferase
subject: Biology--Molecular

description: Benzylisoquinoline alkaloids (BIA) constitute a family of plant specialized metabolites comprising numerous bioactive compounds. BIA metabolism has been extensively studied in the opium poppy and related species in the Ranunculales order, but limited research has been conducted in non-model plants. Sacred lotus (Nelumbo nucifera), in the order Proteales, is an ancient aquatic plant rich in proaporphine, aporphine, and bisbenzylisoquinoline alkaloids, with a prevalence of unusual R-enantiomers. However, BIA biosynthetic genes and cognate enzymes in this plant remain unknown.Considering the proposed monophyletic origin of BIA biosynthesis in Angiosperms and sacred lotus’ reported alkaloid profile, opium poppy’s well-established pathways could be envisaged as a blueprint to predict the corresponding biosynthetic genes in N. nucifera. This thesis describes the isolation and characterization of several genes involved in Nelumbo’s BIA metabolism, including those purportedly encoding for norcoclaurine synthase, O- and N-methyltransferases, proaporphine synthase, bisbenzylisoquinoline synthase, and aporphine methylenedioxy bridge synthase. Through a combination of in vitro assays with recombinant enzymes and plant total protein extracts and organ-specific correlational analysis between transcript levels and alkaloid content, we demonstrate that NnOMT1 acts as the main 6-O-methyltransferase (favoring the conversion of (R)-norcoclaurine), whereas NnOMT5 and NnOMT7 are non-stereospecific 7-O-methyltransferases acting on several 1-benzylisoquinolines. Additionally, in vivo assays performed in engineered yeast strains allowed the preliminary characterization of three novel P450 catalysts, NnCYP80Q1 acting as a proaporphine synthase (R-stereospecific intramolecular C-C phenol coupling), NnCYP80Q2 as a bisbenzylisoquinoline synthase (R-stereospecific intermolecular C-O phenol coupling), and NnCYP719A22, the aporphine methylenedioxy bridge synthase. Furthermore, we describe how the absence of 3'-hydroxylase activity radically changes the alkaloid profile in Proteales versus Ranunculales.In addition, via in vivo deuterium labeling experiments, this work provides the first empirical evidence to support that L-tyrosine is the primary precursor for lotus BIA. Based on a consistent absence of norcoclaurine synthase activity for the recombinant enzyme candidates and plant total protein extracts, we suggest that a non-enzymatic spontaneous Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde produces racemic norcoclaurine in lotus, in opposition to the enzyme-catalyzed (S)-norcoclaurine formation in the Ranunculales. These results support a possible convergent evolution of BIA biosynthesis in sacred lotus.
Evaluating the Behaviour of Salinity and Potential Determining Ions (PDIs) by Zeta Potentiometric and Coreflooding Study in Smart-Water Flooding Carbonate Reservoirs
Creators: name: Gopani, Paras H
Publisher: name: Schulich School of Engineering
Year: 2021
Subjects: subject: smart waterflooding
subject: low salinity waterflooding
subject: potential determining ions
subject: carbonate rocks
subject: wettability alteration
subject: oil-brine-rock interactions
subject: zeta potential
subject: Energy
subject: Engineering--Petroleum
subject: Engineering--Chemical
subject: Geology
subject: FOS: Earth and related environmental sciences

description: The presence of potential determining ions (PDIs) in the injection water along with an optimum salinity is essential for enhanced oil recovery to achieve a more favourable water-wetness in carbonates. Smart waterflooding is a method of reducing the salinity and modifying the ionic chemistry of injection brine to increase water-wetness favourably leading to additional oil recovery. The process can be further optimized to achieve higher incremental oil recovery by selectively spiking the injection brine with PDIs such as SO42- Ca2+ and Mg2+. To understand the mechanisms, a detailed study was conducted to evaluate of the positive influence of major PDIs and salinity reduction on wettability alteration. Zeta potentiometric and coreflooding experiments were conducted using diluted- and smart-brines prepared by varying the composition of PDIs. Two corefloods were conducted through composite cores made up of core plugs arranged in series and results were analysed. The first coreflood used seawater and 100 times diluted-seawater and the second coreflood was conducted using smart brines. Finally, a reservoir simulation study was conducted to match and validate displacement results from both corefloods. Zeta potential and coreflooding experiments with diluted brines and smart brines gave positive results in that the zeta potential was found to be increasing with increasing dilution of SW. This finding was also corroborated by results from coreflooding in both secondary and tertiary modes of recovery. An incremental oil recovery of about ~28% was obtained by 1%dSW from both corefloods, and an increase in sulfate ion concentration in successive brines yielded about ~19.35% additional oil recovery. To validate the experimental results, a single porosity simulation model was used to history match the coreflooding data. The model provided a reasonable match with experimental results and showed that rock dissolution is an important mechanism by analysing the brine and mineral parameters. Other mechanisms discussed through integration of zeta potentiometric and coreflooding experiments are electric double layer (EDL) and surface ion exchange. A combination of these mechanisms is concluded to enhance oil recovery by smart waterflooding. The study demonstrates that injected brines with optimized salinity and concentration of PDIs can be effective in improving recovery by wettability alteration to more water-wet state.
Electroweak Baryogenesis and Higgs Signatures
Creators: name: Cohen, Timothy
name: Morrissey, David E.
name: Pierce, Aaron
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We explore the connection between the strength of the electroweak phase transition and the properties of the Higgs boson. Our interest is in regions of parameter space that can realize electroweak baryogenesis. We do so in a simplified framework in which a single Higgs field couples to new scalar fields charged under SU(3)_c by way of the Higgs portal. Such new scalars can make the electroweak phase transition more strongly first-order, while contributing to the effective Higgs boson couplings to gluons and photons through loop effects. For Higgs boson masses in the range 115 GeV < m_h < 130 GeV, whenever the phase transition becomes strong enough for successful electroweak baryogenesis, we find that Higgs boson properties are modified by an amount observable by the LHC. We also discuss the baryogenesis window of the minimal supersymmetric standard model (MSSM), which appears to be under tension. Furthermore, we argue that the discovery of a Higgs boson with standard model-like couplings to gluons and photons will rule out electroweak baryogenesis in the MSSM.
description: 21 pages, 4 figures; v2 refs added, minor changes, matches journal version
title: Can apparent diffusion coefficient (ADC) values improve the diagnosis of peripheral zone prostate cancer (PZPCa) in PIRADSv2 score 4?
Creators: name: Verna, Silvia
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Genital / Reproductive system male
subject: Oncology
subject: MR-Diffusion/Perfusion
subject: Diagnostic procedure
subject: Biopsy
subject: Cancer
subject: Outcomes

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Multiparametric Magnetic Resonance Imaging (mpMRI) has a good diagnostic accuracy in detecting clinically significant prostate cancer (csPCa), defined as Gleason Score (GS)≥3+4,with a negativepredictive value ranging from 63% to 98%...
Applications of Data Science to Electronic Health Data in Health Services Research
Creators: name: Lee, Seungwon
Publisher: name: Cumming School of Medicine
Year: 2022
Subjects: subject: Electronic medical records
subject: Health services
subject: Data science
subject: Health Sciences--General

description: The application of data science to medical big data is an essential for achieving precision medicine and building a learning health system. There are many electronic health databases that contain big data in medicine. Largely, these electronic health databases are divided into administrative data, electronic medical records (EMR) data, and other types such as clinical registries. These databases were designed for different purposes and have informed the health system and stakeholders. Bringing together these datasets for data-driven research is an essential step. This manuscript-based thesis focuses on applying data science to electronic health data. The first part of this thesis explores the Allscripts Sunrise Clinical Manager (SCM) EMR data for research purposes, including its advantages and challenges. The work then proceeds to establish a linkage process of this database with other databases for establishing a disease cohort. The second part presents a systematic scoping review that explores how data science has been applied to similarly linked data to define conditions and comorbidities. Capturing comorbidities and outcomes is fundamental for studying treatment effects and tailoring medical decisions. The third and last part narrows the focus disease to non-alcoholic fatty liver disease and applies data science methodologies to answer specific disease-context related health services research questions. The completion of this work demonstrates the successful application of data science to electronic health data for health services research. Specifically, the first part paves the way for routinely using SCM EMR data for research in Alberta. Organizational procedures on data storage and transfer are also mapped out. These activities may not be of direct scientific value but are crucial for building the infrastructure capable of supporting scientific works. Second part informs the current data science applications on how to identify comorbidities and outcomes. This part sheds light on the potential directions of currently ongoing and future research. The third part successfully combines data analytics and existing health services research methods (i.e., epidemiology), and demonstrates that data tools can be developed to reduce the burden on care providers and the health system. Multidisciplinary collaboration and inputs from diverse perspectives are vital for achieving precision medicine.
title: Acute pancreatitis: learning Atlanta classification and local complications
Creators: name: Melo, Tatiana
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Abdomen
subject: Pancreas
subject: CT
subject: Diagnostic procedure
subject: Contrast agent-intravenous
subject: Education and training
subject: Pathology
subject: Abscess

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Systematize Atlanta classification nomenclature that allow reliable classification of acute pancreatitis Learn the adequate timings to perform CT evaluation/re-evaluation to obtain the best morphologic information Review imaging features of the most...
title: The spectrum of endometriosis: correlation of MRI characteristics and laparoscopy
Creators: name: Nota, Irene
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Education and training
subject: Education
subject: MR
subject: Pelvis
subject: Genital / Reproductive system female
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The purpose of this educational exhibit is to describe MR characteristics in correlation with laparoscopic...
Prolonged Post-Orogenic Extension in the Southeastern Canadian Cordillera: Miocene Reactivation of the Columbia River Fault
Creators: name: Damant, Kade A.
Publisher: name: Science
Year: 2022
Subjects: subject: Thermochronology
subject: apatite (U-Th)/He
subject: apatite fission track
subject: tectonics
subject: extension
subject: Canadian Cordillera
subject: Geology
subject: FOS: Earth and related environmental sciences

description: Post-orogenic extension in the southeastern Canadian Cordillera manifests in the form of normal faults and metamorphic core complexes exhumed during the Paleocene–Eocene, but new thermochronology data suggest this interval may be longer. The Columbia River fault is an east-dipping brittle-ductile normal fault bounding the eastern margin of the Monashee Complex. Apatite fission track and (U-Th)/He data were collected from granitic and metamorphic bedrock along two elevation profiles across the Columbia River fault north of Revelstoke, BC. Ten apatite fission track ages range from 29.3–17.7 Ma and eleven apatite (U-Th)/He ages range from 26.6–7.0 Ma. Inverse thermal history modelling suggest the footwall underwent rapid cooling between 18–16 Ma. Whereas, the hanging wall experienced more protracted cooling from 40 Ma to present with two small cooling pulses at 20 and 10 Ma. These new data suggest the Columbia River fault was reactivated in the early Miocene and exhumed the Monashee Complex an additional ~2 km. Combining all thermochronology data from the region suggests three phases of accelerated cooling in the Monashee Complex: 1) Eocene (56–33 Ma), 2) Miocene (20–17 Ma), and 3) Pliocene to recent (2.8–0 Ma).Inverse thermal history modelling of apatite and zircon (U-Th)/He and apatite fission track data elsewhere in the southern Canadian Cordillera also exhibit an early Miocene cooling pulse. Widespread exhumation at this time coincides with an early Miocene plate tectonic reorganization of the Pacific-North American margin which resulted in an increase in transtension in North America. The Columbia River fault is proposed to be reactivated as a splay fault associated with dextral strike slip faulting along the Rocky Mountain Trench in the early Miocene, driven by a change in plate boundary forces. Building on previous models, pre-existing gravitational instabilities in the southeastern Canadian Cordillera aided in lateral extension of the upper crust along unstable inherited structures throughout the Shuswap domain.
Vacuum fluctuations of the supersymmetric field in curved background
Creators: name: Bilic, Neven
name: Domazet, Silvije
name: Guberina, Branko
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We study a supersymmetric model in curved background spacetime. We calculate the effective action and the vacuum expectation value of the energy momentum tensor using a covariant regularization procedure. A soft supersymmetry breaking induces a nonzero contribution to the vacuum energy density and pressure. Assuming the presence of a cosmic fluid in addition to the vacuum fluctuations of the supersymmetric field an effective equation of state is derived in a self-consistent approach at one loop order. The net effect of the vacuum fluctuations of the supersymmetric fields in the leading adiabatic order is a renormalization of the Newton and cosmological constants.
description: 14 pages, references added, revised argument on vacuum energy subtraction in section 1, discussion expanded, results unchanged