cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of Treatment outcomes following continuous miglustat therapy in patients with Niemann-Pick disease Type C: a final report of the NPC Registry
Creators: name: Patterson, Marc C.
name: Mengel, Eugen
name: Vanier, Marie T.
name: Moneuse, Patrick
name: Rosenberg, Daniel
name: Pineda, Mercedes
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences
subject: Computational Biology

description: Additional file 1: Supplementary Table 1. Countries from which patients were enrolled to the NPC Registry up until database closure. Additional file 1: Supplementary Table 2. Reasons for discontinuation of miglustat treatment.
Discovery of a Dusty Ring in the Coalsack: A Dense Core Caught in the Act of Formation?
Creators: name: Lada, Charles J.
name: Huard, Tracy L.
name: Crews, Lionel J.
name: Alves, Joao F.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present a new infrared extinction study of Globule 2, the most opaque molecular cloud core in the Coalsack complex. Using deep near-infrared imaging observations obtained with the ESO NTT we are able to examine the structure of the globule in significantly greater detail than previously possible. We find the most prominent structural feature of this globule to be a strong central ring of dust column density which was not evident in lower resolution studies of this cloud. This ring represents a region of high density and pressure that is likely a transient structure. For a spherical cloud geometry the ring would correspond to a dense inner shell of high pressure that could not be in dynamical equilibrium with its surroundings since there appear to be no sources of pressure in the central regions of the cloud that could support the shell against gravity and prevent its inward implosion. The timescale for the inward collapse of the ring would be less than 2 x 10^5 years, suggesting that this globule is in an extremely early stage of evolution, and perhaps caught in the process of forming a centrally condensed dense core or Bok globule. Outside its central regions the globule displays a well-behaved density profile whose shape is very similar to that of a stable Bonnor-Ebert sphere. Using SEST we also obtained a C18O spectrum toward the center of the cloud. The CO observation indicates that the globule is a gravitationally bound object. Analysis of the CO line profile reveals significant non-thermal gas motions likely due to turbulence. As a whole the globule may be evolving to a global state of quasi-static dynamical equilibrium in which thermal and turbulent pressure balance gravity.
description: Contains 21 pages and 5 figures. Due to space limitations in astroph, figures 1, 3 & 5 are submitted as separate .jpg files. Full resolution figures and text can be downloaded from http://cfa-www.harvard.edu/~clada/preprints.html
Polar surface engineering in ultra-thin MgO(111)/Ag(111) -- possibility of metal-insulator transition and magnetism
Creators: name: Arita, Ryotaro
name: Tanida, Yoshiaki
name: Entani, Shiro
name: Kiguchi, Manabu
name: Saiki, Koichiro
name: Aoki, Hideo
Publisher: name: arXiv
Year: 2004
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: A recent report [Kiguchi {\it et al.}, Phys. Rev. B {\bf 68}, 115402 (2003)] that the (111) surface of 5 MgO layers grown epitaxially on Ag(111) becomes metallic to reduce the electric dipole moment raises a question of what will happen when we have fewer MgO layers. Here we have revealed, first experimentally with electron energy-loss spectroscopy, that MgO(111) remains metallic even when one-layer thick, and theoretically with the density functional theory that the metallization should depend on the nature of the substrate. We further show, with a spin-density functional calculation, that a ferromagnetic instability may be expected for thicker films.
description: 5 pages, 7 figures
Heating triangle singularities in heavy ion collisions
Creators: name: Abreu, Luciano M.
name: Llanes-Estrada, Felipe J.
Publisher: name: arXiv
Year: 2020
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We predict that triangle singularities of hadron spectroscopy can be strongly affected in heavy ion collisions. To do it we examine various effects on the singularity-inducing triangle loop of finite temperature in the terminal hadron phase. It appears that peaks seen in central heavy ion collisions are more likely to be hadrons than rescattering effects under two conditions. First, the flight-time of the intermediate hadron state must be comparable to the lifetime of the equilibrated fireball (else, the reaction mostly happens in vacuo after freeze out). Second, the medium effect over the triangle-loop particle mass or width must be sizeable. When these (easily checked) conditions are met, the medium quickly reduces the singularity: at T about 150 MeV, even by two orders of magnitude, acting then as a spectroscopic filter.
description: 9 pages, 13 plots
Additional file 1 of Do probiotics promote oral health during orthodontic treatment with fixed appliances? A systematic review
Creators: name: Hadj-Hamou, Riham
name: Abiola C. Senok
name: Athanasiou, Athanasios E.
name: Kaklamanos, Eleftherios G.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Table S1. Eligibility criteria for the present systematic review. Table S2. Strategy for database search (up to September 1st, 2019). Table S3. Studies excluded during full-text eligibility assessment with reasons.
Performance of the BGSDC integrator for computing fast ion trajectories in nuclear fusion reactors
Creators: name: Tretiak, Krasymyr
name: Buchanan, James
name: Akers, Rob
name: Ruprecht, Daniel
Publisher: name: arXiv
Year: 2020
Subjects: subject: Computational Physics (physics.comp-ph)
subject: Numerical Analysis (math.NA)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: Modelling neutral beam injection (NBI) in fusion reactors requires computing the trajectories of large ensembles of particles. Slowing down times of up to one second combined with nanosecond time steps make these simulations computationally very costly. This paper explores the performance of BGSDC, a new numerical time stepping method, for tracking ions generated by NBI in the DIII-D and JET reactors. BGSDC is a high-order generalisation of the Boris method, combining it with spectral deferred corrections and the Generalized Minimal Residual method GMRES. Without collision modelling, where numerical drift can be quantified accurately, we find that BGSDC can deliver higher quality particle distributions than the standard Boris integrator at comparable cost or comparable distributions at lower cost. With collision models, quantifying accuracy is difficult but we show that BGSDC produces stable distributions at larger time steps than Boris.
description: New version has multiple updates, clarifications in the text and new figures
title: Physeal tongue in the distal femur
Creators: name: Aydingöz, Üstün
Publisher: name: EURORAD
Year: 2021
Subjects: subject: Musculoskeletal system
subject: Extremities
subject: Musculoskeletal bone
subject: Paediatric
subject: MR
subject: Extremities
subject: Musculoskeletal bone
subject: Paediatric
subject: Extremities
subject: Musculoskeletal bone
subject: Paediatric
subject: Clinical Cases

description: Clinical History: A 9-year-old boy with mild right knee pain. The only significant history of trauma is a fall from a bicycle at 5 years of age.

description: 9 years, male
Rentowność produkcji pszenicy zwyczajnej w UE
Profitability of Common Wheat Production in the EU
Creators: name: Gołaś, Zbigniew
name: Gołaś, Zbigniew
Publisher: name: Unknown
Year: 2017
Subjects: subject: Agribusiness
subject: Crop Production/Industries
subject: International Relations/Trade
subject: Production Economics
subject: Productivity Analysis
subject: common wheat
subject: production profitability
subject: EU
subject: panel regression
subject: pszenica zwyczajna
subject: rentowność produkcji
subject: regresja panelowa

description: The main aim of the article is to present multidimensional analysis of profitability of common wheat production in EU farms. The research focused on EU member states in years 2007-2013 and was based on statistical data published by the European Commission in EU Cereal Farms Reports. The profitability of common wheat production was analysed on the basis of income and expenditure accounts, which allowed to conduct multileveled evaluation of farms' ability to generate income from wheat production measured with gross and net margins. Furthermore, the panel regression model was used in order to identify strenght and direction of influence of chosen technical and economic price and cost characteristics on profitability of wheat production. In the light of panel model parameters, price and yield of wheat and both energy and fertilisation costs should be considered as most influential factors. / Synopsis. Głównym celem artykułu była wielowymiarowa analiza rentowności produkcji pszenicy zwyczajnej w gospodarstwach rolnych krajów UE. Badania przeprowadzono w układzie krajów Unii Europejskiej za lata 2007-2013 na podstawie danych publikowanych przez Komisję Europejską w raportach EU Cereal Farms Report. Rentowność produkcji pszenicy analizowano na podstawie rachunku przychodów i kosztów, który umożliwia wielowymiarową ocenę zdolności gospodarstw do generowania zysków z produkcji pszenicy mierzoną rentownością brutto i netto. Ponadto, w celu identyfikacji siły i kierunku wpływu wybranych charakterystyk techniczno-ekonomicznych, cenowych oraz kosztowych na rentowność produkcji pszenicy zastosowano metody regresji panelowej. W świetle parametrów regresji panelowej na zmienność rentowność produkcji pszenicy najsilniej wpływały ceny i plony pszenicy oraz koszty nawożenia i koszty energii.
description: eISSN 2544-0659
Supplementary Data for Rat PD-model virome analysis
Creators: name: Stockdale, Stephen
Publisher: name: figshare
Year: 2021
Subjects: subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: Computational Biology
subject: Microbiology
subject: FOS: Biological sciences

description: The supplementary data and scripts required to generate the images and interpret the results of the study: "Alpha-synuclein alters the faecal viromes of rats in a gut-initiated model of Parkinson’s disease".
On the Detectability of Turbulence and Bulk Flows in X-ray Clusters
Creators: name: Sunyaev, Rashid A.
name: Norman, Michael L.
name: Bryan, Greg L.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Cooling flows, cluster mergers and motions of galaxies through the cluster gas with supersonic and sonic velocities must lead to large scale motions of the intracluster medium (ICM). A high-resolution numerical simulation of X-ray cluster formation by Norman and Bryan predicts cluster-wide turbulence with v_turb ~ 300-600 ~km/s and eddy scales l_outer ~ 100-500 kpc, the larger numbers being characteristic of turbulence near the virial radius, while the smaller numbers pertain to the core. The simulation also predicts the existence of ordered bulk flows in the core with v ~ 400 km/s on scales of several hundred kpc. In this paper we consider the observability of such fluid motions via the distortions it induces in the CMB via the kinematic SZ effect, as well as via Doppler broadening and shifting of metal lines in the X-ray spectrum. We estimate |ΔT/T|_kinematic < few X 10^{-6} -- at or below current limits of detectability. However, we find that an energy resolution of a few eV is sufficient to detect several Doppler shifted components in the 6.7 keV Fe line in the core of the cluster.
description: 13 pages, 5 figures, Astronomy Letters, accepted
title: Moral Identity Work in Senior Business Managers
Creators: name: Wishart, Maria
Publisher: name: The Open University
Year: 2018

description: This thesis adopts a social constructionist epistemology and a narrative analysis research method to explore the moral identity work of senior managers in UK for-profit businesses. Analysis of thirty semi-structured interview transcripts was carried out using the Nvivo data analysis software package, guided by Gioia et al’s (2013) systematic approach to qualitative data analysis. The study identifies one overarching theme – that of the loneliness of seniority, which underpins the moral identity work of participants. Participants articulate the loneliness of seniority with recourse to three main tactics – describing intense pressure to deliver against business objectives, expressing the weight of expectation that they perceive from many stakeholders, and asserting that they feel caught between those above and below them in their organisational hierarchies. Two further themes are elaborated. In the first – reaffirming themselves as essentially moral - participants assert that they have a moral core, with recourse to nostalgia for childhood. In the second - becoming and being moral managers - they assert their roles as moral champions by characterising their organisations as systems that threaten to thwart their moral agendas, and which they need to resist. These findings contribute to understanding in the under-researched area of individual moral identity within a business context, as well as offering a fresh perspective to the broader field of business ethics research. The research makes contributions to theory in several areas, notably to the theories of nostalgia and of stigma management in identity work, and to the theory of resistance as an identity work stratagem. It also contributes to practice with the findings that feelings of isolation persist beyond middle management, and that moral issues in the workplace are experienced in a remarkably similar way in individuals from different business functions and sectors.
The regulation of HIV-1 replication by the transcription factors USF1, USF2, and TFII-I (RBF-2)
Creators: name: Malcolm, Thomas E.
Publisher: name: University of British Columbia
Year: 2011

description: Despite efforts to eliminate the HIV-1 virus from infected individuals, the virus persists in a latent chromosomally integrated pool of provirus that evades current drug therapy. Upon cessation of highly active anti-retroviral therapy (HAART), the latent virus begins to replicate resulting in an increased viral titre in the patient's serum, leading to Acquired Immune Deficiency Syndrome (AIDS). A great amount of effort has gone into determining the mechanisms involved in the establishment of viral latency, in order to find targets that can be used in combination with existing therapies to eradicate the virus. In this thesis, I characterize a protein complex that is required for viral replication of integrated virus and therefore has potential as a therapeutic target. The data presented in this thesis identify USF1, USF2, and TFII-I as the proteins that comprise the Ras-response element Binding Factor-2 (RBF-2), which binds constitutively to the Ras-response Factor Binding Elements I and III (RBEI and RBEIII) within the Long Terminal Repeat (LTR) promoter. RBEIII is highly conserved in sequence and position relative to the transcriptional start site. In addition, both RBEIII and RBEI are situated near nucleosomes in the LTR enhancer region. Furthermore, I provide evidence that RBF-2 proteins are modified by phosphorylation in response to T-cell activation. Finally, I demonstrate that mutations in RBEIII that prevent the binding of these factors, as measured by electrophoretic mobility shifting assays, also prevent HIV-1 activation, as observed from stably integrated reporter virus.
Additional file 1 of Acupressure to improve sleep quality of older people in residential aged care: a randomised controlled trial protocol
Creators: name: Nant Thin Thin Hmwe
name: Browne, Graeme
name: Lyndall Mollart
name: Viv Allanson
name: Chan, Sally Wai-Chi
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. SPIRIT checklist.
The Wiener test for higher order elliptic equations
Creators: name: Maz'ya, Vladimir
Publisher: name: arXiv
Year: 2003
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: Wiener's criterion for the regularity of a boundary point with respect to the Dirichlet problem for the Laplace equation has been extended to various classes of elliptic and parabolic partial differential equations. They include linear divergence and nondivergence equations with discontinuous coefficients, equations with degenerate quadratic form, quasilinear and fully nonlinear equations, as well as equations on Riemannian manifolds, graphs, groups, and metric spaces. A common feature of these equations is that all of them are of second order, and Wiener type characterizations for higher order equations have been unknown so far. Indeed, the increase of the order results in the loss of the maximum principle, Harnack's inequality, barrier techniques, and level truncation arguments, which are ingredients in different proofs related to the Wiener test for the second order equations. In the present work we extend Wiener's result to elliptic differential operators $L(\partial)$ of order $2m$ in the Euclidean space ${\bf R}^n$ with constant real coefficients $$L(\partial)=(-1)^m\sum_{|α|=|β|=m}a_{αβ} \partial^{α+ β}.$$ The results can be extended to equations with variable (for example, Hölder continuous) coefficients in divergence form but we leave aside this generalization to make exposition more lucid.
The $ρ$ parameter and $H^0\to \ell_i \ell_j$ in models with TeV sterile neutrinos
Creators: name: Hernández-Tomé, G.
name: Illana, J. I.
name: Masip, M.
Publisher: name: arXiv
Year: 2020
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The presence of massive sterile neutrinos $N$ mixed with the active ones induces flavor violating processes in the charged lepton sector at the loop level. In particular, the amplitude of $H^0\to \bar{\ell}_i\ell_j$ is expected to be proportional to the product of heavy-light Yukawa couplings $y_iy_j=2 \,s_{ν_i} s_{ν_j}\, m_N^2/v^2$, where $s_{ν_{i,j}}$ express the heavy-light neutrino mixings. Here we revisit these Higgs decays in the most generic extension of the neutrino sector, focusing on large values of $y_{i}$. We show that decoupling effects and a cancellation between the two dominant contributions to these processes makes the amplitude about one hundred times smaller than anticipated. We find that perturbative values of $y_{i}$ giving an acceptable contribution to the $ρ$ parameter imply ${\cal B}(H^0\to \bar{\ell}_i\ell_j)<10^{-8}$ for any lepton flavors, a rate that is not accessible at current colliders.
description: Comments and references added, version accepted for publication in PRD
Additional file 1 of A pan-cancer analysis of the clinical and genetic portraits of somatostatin receptor expressing tumor as a potential target of peptide receptor imaging and therapy
Creators: name: Hyunjong Lee
name: Minseok Suh
name: Hongyoon Choi
name: Seunggyun Ha
name: Paeng, Jin Chul
name: Cheon, Gi Jeong
name: Kang, Keon Wook
name: Lee, Dong Soo
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry

description: Additional file 1:. Supplementary fig. 1 Association between prognosis and SST2 expression level. High-SST2 status tended to be a poor prognostic factor when limited to TNBC subjects without statistical significance (p = 0.16) (a). When normal kidney tissue was defined as a reference, thymoma with low SST2 status and glioblastoma with high-SST2 status showed good prognosis (b-c)
Identification of novel genes affecting body wall muscle in Caenorhabditis elegans
Creators: name: Warner, Adam Dennis
Publisher: name: University of British Columbia
Year: 2011

description: Muscular diseases affect many people worldwide. While we have learned much about the sarcomere, the basic building block of muscle cells, there are still numerous questions that remain to be answered. In fact, all of the proteins involved in the formation and maintenance of the sarcomere have yet to be catalogued and studied. We must learn more about proteins expressed in muscle and how they interact so that better treatments for myopathies can be produced. In this thesis, several novel sarcomeric proteins have been identified using Caenorhabditis elegans as a model organism. A list of genes expressed in muscle cells was compiled using available Serial Analysis of Gene Expression (SAGE) and microarray data. By eliminating or severely reducing the expression of each gene using RNA interference (RNAi), we were able to determine which genes were required for proper myofilament organization. Of 23 genes known to affect muscle, 16 were identified using this methodology. In total 119 genes were found to be necessary for proper myofilament organization, 103 of which are genes without a previously characterized role in muscle. In addition, a bioinformatics based screen that utilized tissue specific SAGE data in C. elegans yielded a number of potential candidate muscle affecting genes, and one, C28H8.6 was further studied. C28H8.6 consists of both an ' a ' and a ' b ' isoform, one of which, C28H8.6a has 4 LIM domains and bears striking sequence similarity to the focal adhesion protein paxillin. In animals homozygous for a mutation that knocks out both isoforms of C28H8.6, movement is uncoordinated and development is arrested at the first larval stage. We have demonstrated using isoform specific RNAi that knocking down expression of C28H8.6b has no observable effect on development, while C28H8.6a is required for proper larval growth and movement. Further study on this isoform verified that C28H8.6a co-localizes to dense bodies with a- actinin and is required for proper organization of myofilaments within the sarcomere.
Dissecting contact tracing apps in the Android platform
Creators: name: Kouliaridis, Vasileios
name: Kambourakis, Georgios
name: Chatzoglou, Efstratios
name: Geneiatakis, Dimitrios
name: Wang, Hua
Publisher: name: arXiv
Year: 2020
Subjects: subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences

description: Contact tracing has historically been used to retard the spread of infectious diseases, but if it is exercised by hand in large-scale, it is known to be a resource-intensive and quite deficient process. Nowadays, digital contact tracing has promptly emerged as an indispensable asset in the global fight against the coronavirus pandemic. The work at hand offers a meticulous study of all the official Android contact tracing apps deployed hitherto by European countries. Each app is closely scrutinized both statically and dynamically by means of dynamic instrumentation. Depending on the level of examination, static analysis results are grouped in two axes. The first encompasses permissions, API calls, and possible connections to external URLs, while the second concentrates on potential security weaknesses and vulnerabilities, including the use of trackers, in-depth manifest analysis, shared software analysis, and taint analysis. Dynamic analysis on the other hand collects data pertaining to Java classes and network traffic. The results demonstrate that while overall these apps are well-engineered, they are not free of weaknesses, vulnerabilities, and misconfigurations that may ultimately put the user security and privacy at risk.
description: Fixed issues with Figures
Entanglement versus Correlations in Spin Systems
Creators: name: Verstraete, F.
name: Popp, M.
name: Cirac, J. I.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Quantum Physics (quant-ph)
subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: We consider pure quantum states of $N\gg 1$ spins or qubits and study the average entanglement that can be \emph{localized} between two separated spins by performing local measurements on the other individual spins. We show that all classical correlation functions provide lower bounds to this \emph{localizable entanglement}, which follows from the observation that classical correlations can always be increased by doing appropriate local measurements on the other qubits. We analyze the localizable entanglement in familiar spin systems and illustrate the results on the hand of the Ising spin model, in which we observe characteristic features for a quantum phase transition such as a diverging entanglement length.
description: 4 pages
title: Clinical Relevance of Immune Cells in Pancreatic Adenocarcinoma and their Implication in Immunotherapy
Creators: name: Castino, Giovanni Francesco
Publisher: name: The Open University
Year: 2018

description: This thesis summarizes the work I have done during my PhD training, focused on the immune microenvironment of pancreatic adenocarcinoma (PDAC). The aim was to delineate key features of immunologic and tumour components shaping the biology of pancreatic cancer. Immunotherapy has been largely explored as a promising anticancer approach but not convincingly introduced yet for this tumour type. The results here summarized could contribute to a better understanding of the microenvironment of human PDAC and foster the introduction of immunotherapeutic strategies into the clinical practice. The first section of the thesis summarizes the work done to investigate the occurrence of tertiary lymphoid tissue (TLT) in PDAC. TLT has been demonstrated to coordinate the recruitment and activation of adaptive immune cells in several tumour settings. This work documents the occurrence of TLT in pancreatic cancer, addresses the prognostic role of B cells according to their spatial distribution within TLT and tests the hypothesis that TLT can serve as immunological sites that contribute to efficacy of immunotherapeutic vaccination. The second section is focused on the intersection between cancer metabolism and immune function in PDAC. In order to unearth early metabolic alterations in PDAC, we have analyzed the pancreatic juice, a relatively unexplored liquid biopsy potentially enriched with tumor-derived metabolites. Our results indicate a specific metabolic signature that allows to single out PDAC from other pancreatic pathologies and reveal an important link between glucose metabolism and accumulation of PD-1+ cells in PDAC tumors.
Cultural Representations in Digital Games (Editorial)
Creators: name: Vairinhos, Mario
name: Costa, Liliana Vale
name: Cardoso, Pedro
Publisher: name: Journal of Digital Media & Interaction
Year: 2021

description: Welcome to this new issue of the Journal of Digital Media & Interaction. As we are heading towards New Year’s Eve, it is our pleasure to devote this entire issue to the production of a Dossier dedicated to the exchange of meaning that our language may convey within physically simulated or fictionally recreated worlds in digital games... Editorial of the nº11, vol. 4, of 2021.
description: Journal of Digital Media & Interaction, vol. 4 n.º 11 (2021): Cultural Representations in Digital Games, Vol.4, No.11
Multicellular sensing at a feedback-induced critical point
Creators: name: Vennettilli, Michael
name: Erez, Amir
name: Mugler, Andrew
Publisher: name: arXiv
Year: 2020
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Molecular Networks (q-bio.MN)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Feedback in sensory biochemical networks can give rise to bifurcations in cells' behavioral response. These bifurcations share many properties with thermodynamic critical points. Evidence suggests that biological systems may operate near these critical points, but the functional benefit of doing so remains poorly understood. Here we investigate a simple biochemical model with nonlinear feedback and multicellular communication to determine if criticality provides a functional benefit in terms of the ability to gain information about a stochastic chemical signal. We find that when signal fluctuations are slow, the mutual information between the signal and the intracellular readout is maximized at criticality, because the benefit of high signal susceptibility outweighs the detriment of high readout noise. When cells communicate, criticality gives rise to long-range correlations in readout molecule number among cells. Consequently, we find that communication increases the information between a given cell's readout and the spatial average of the signal across the population. Finally, we find that both with and without communication, the sensory benefits of criticality compete with critical slowing down, such that the information rate, as opposed to the information itself, is minimized at the critical point. Our results reveal the costs and benefits of feedback-induced criticality for multicellular sensing.
description: 15 pages, 5 figures
Playing Sites of Memory: Framing the Representation of Cultural Memory in Digital Games
Creators: name: Caselli, Stefano
Publisher: name: Journal of Digital Media & Interaction
Year: 2021

description: Basing on an understanding of digital games as cultural objectivations, this article suggests interpreting them as sites of memory, or in other words as ‘carrier’ of cultural memory. By merging game studies, literary studies, and memory studies, the article aims at providing an operational and theoretical toolkit useful to put different kinds of representation within (and beyond) digital games towards a broader cultural memory framework. The toolkit is inspired by Paul Ricoeur and his threefold model of textual mimesis, and favours an approach to digital games that takes into account how they represent and re- configure pre-existent cultural forms; and therefore can be refigured into novel ones during, after, and beyond the game experience.
description: Journal of Digital Media & Interaction, vol. 4 n.º 11 (2021): Cultural Representations in Digital Games, Vol.4, No.11
Defining a Conceptual Framework for a Toolkit to Game Design
Creators: name: Aresta, Mónica
name: Beça, Pedro
name: Santos, Rita
name: Veloso, Ana Isabel
Publisher: name: Journal of Digital Media & Interaction
Year: 2021

description: Seeking to capitalize the interest of younger audiences in game creation activities, the Gamers4Nature project aims to develop a toolkit designed to support game design by allowing the manipulation of the several elements that compose a game. Prior to the toolkit’s development, there was the need to establish the respective conceptual framework. This paper describes the process of defining the project’s conceptual framework. Based on Fullerton’s perspective on game design, the framework was defined following a participatory design approach with the participation of different stakeholders (postgraduate students with extensive knowledge about game design and experts in the game design field). To ease the discussion sessions, a physical artifact (19 hexagonal pieces, and a honeycomb structured board) was developed. Results suggest that a non-linear approach to game design may promote not only the definition of the game’s structure and gameplay but also allow a contextualised analysis of all its elements.
description: Journal of Digital Media & Interaction, vol. 4 n.º 11 (2021): Cultural Representations in Digital Games, Vol.4, No.11
Processo de transformação de linguagem a partir de um estudo netnográfico de Valorant
Creators: name: Ferreira, Rafaelly Freitas
name: Do Nascimento Melquiades, Felipe Sampaio
name: Brito Alencar Araripe, Diogo Souza
Publisher: name: Journal of Digital Media & Interaction
Year: 2021

description: This article demonstrates a study on the process of language transformation and its influences on the Valorant electronic game community. The research was conducted through immersion in the game itself, and in the Facebook and Twitch communities. Through a netnography based on the ideas of Malinowski, Kozinets and Waslawick, a glossary was produced with the clipping of 59 terms used by the studied community. The terms were categorized and based on that, hypotheses were raised on how the language adapted to the players' reality.
description: Journal of Digital Media & Interaction, vol. 4 n.º 11 (2021): Cultural Representations in Digital Games, Vol.4, No.11
Contextual extensions of quantum gravity models
Creators: name: Guo, Xiao-Kan
Publisher: name: arXiv
Year: 2020
Subjects: subject: Mathematical Physics (math-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present a simple way of incorporating the structure of contextual extensions into quantum gravity models. The contextual extensions of $C^*$-algebras, originally proposed for contextual hidden variables, are generalized to the cones indexed by the contexts and their limit in a category. By abstracting the quantum gravity models as functors, we study the contextual extensions as the categorical limits of these functors in several quantum gravity models. Such contextual extensions of quantum gravity models are useful for building topos-theoretic models of quantum gravity.
Place de l’environnement dans les curricula marocains des Sciences de la Vie et de la Terre au cycle secondaire
Creators: name: AMEZIANE, Nour-Eddine
Publisher: name: figshare
Year: 2020
Subjects: subject: 50203 Environmental Education and Extension
subject: FOS: Earth and related environmental sciences

description: La gestion des problèmes environnementaux constitue l’un des principaux défis auxquels sont confrontées nos sociétés. L’éducation et la formation constituent des moteurs incontournables de la sensibilisation au développement durable. Le Maroc a toujours connu des réformes de son système éducatif dont les plus frappantes ont été instaurées récemment. Les curricula ont été analysés de manière à avoir introduit des changements dans les programmes tels que l’intégration de nouveaux thèmes d’enseignement, entre autres des sujets relatifs aux problèmes environnementaux. Concernant les méthodes d’enseignement, le ministèrede tutelle a adopté l’approche par compétences, et ce, après l’instauration de la charte nationale de l’éducation et de la formation. La présente étude menée en 2016 vise à évaluer les divers outils déployés par l’école marocaine, particulièrement dans les sciences de la vie et de la terre au cycle secondaire en vue de sensibiliser les jeunes apprenants aux problèmesenvironnementaux. Pour cela nous avons analysé largement le curriculum et les manuels puis nous avons réalisé une enquête au sein de dix établissementsscolaires secondaires afin de vérifier la disponibilité et la convenance du matériel didactique. Les résultats ont montré que la présence du contenu visant à développer les compétences spécifiques liées à l’environnement souffre encore d’une insuffisance dans ce sens. En effet nous avons noté non seulement une lacune touchant l’aspect quantitatif du sujet environnemental mais égalementl’aspect qualitatif. Par ailleurs nous avons noté une dominance du style informatif qui présume une faible implication de l’apprenant dans la construction des savoirs.A cela s’ajoute le problème du matériel didactique quasi absent.
Dipole and Bloch oscillations of cold atoms in a parabolic lattice
Creators: name: Ponomarev, A. V.
name: Kolovsky, A. R.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: The paper studies the dynamics of a Bose-Einstein condensate loaded into a 1D parabolic optical lattice, and excited by a sudden shift of the lattice center. Depending on the magnitude of the initial shift, the condensate undergoes either dipole or Bloch oscillations. The effects of dephasing and of atom-atom interactions on these oscillations are discussed.
description: 3 pages, to appear in proceeding of LPHYS'05 conference (July 4-8, 2005, Kyoto, Japan)
"El galán Castrucho" de Lope de Vega: Edición TEI de la edición de Julián Molina
Creators: name: Fernández Rodríguez, Daniel
Publisher: name: Zenodo
Year: 2019
Subjects: TEI edition
early modern European theatre
Spanish Golden Age drama
Lope de Vega

description: An electronic edition, encoded in XML language following the Guidelines of the Text Encoding Initiative, of Lope de Vega's play El galán Castrucho, edited by Julián Molina (PROLOPE research group), and published as part of the CANON 60 collection of the TC/12 project, 2014. This TEI edition adapts an initial digitisation by the Biblioteca Virtual Miguel de Cervantes, and is the basis of the HTML-PHP text published in the EMOTHE Digital Library  in 2019.
description: Funded by Ministerio de Ciencia, Innovación y Universidades, Agencia Estatal de Investigación (Spain) and FEDER/ERDF through project FFI2016-80314-P.
A Review of Adaptable Serious Games Applied to Professional Training
Creators: name: Pistono, Alvaro Marcos Antonio De Araujo
name: Santos, Arnaldo Manuel Pinto
name: Baptista, Ricardo José Vieira
Publisher: name: Journal of Digital Media & Interaction
Year: 2021

description: Serious Games have been used in professional training to increase employee engagement and improve training initiatives. This review intends to identify the application of Serious Games in professional training and how these games have been developed, evaluated, and adapted to relate to the learning outcomes. It aims to map the use of Serious Games in professional training, verifying which forms of adaptation are used, learning outcomes, and models and frameworks of Serious Games that include game elements. Different learning outcomes associated with Serious Games were identified, in the general context and professional training, with knowledge acquisition being the most investigated result and questionnaires the most used type of assessment. It was found that several technologies are used in the adaptation of Serious Games. This literature review highlighted gaps in Serious Games research, especially in adaptive games applied in the context of professional training, such as the absence of frameworks for adaptive Serious Games and the lack of a framework for Serious Games that relates game elements to learning outcomes.
description: Journal of Digital Media & Interaction, vol. 4 n.º 11 (2021): Cultural Representations in Digital Games, Vol.4, No.11
Higher-pitched bird song towards the coast supports a role for selection in ocean noise avoidance
Creators: name: Sebastianelli, Matteo
name: Blumstein, Daniel T.
name: Kirschel, Alexander N. G.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Neuroscience
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Effective communication in birds is often hampered by background noise, with much research focusing on the effect of anthropogenic noise on passerine bird song. Continuous low-pitch natural noise can drive changes in both spectral and temporal patterning of bird vocalisations, but the extent to which these effects may also affect birds that lack vocal learning is not well understood. We used a gradient of exposure to natural low-frequency noise to assess whether it exerts selective pressure on innate vocalisations. We tested whether three species of Pogoniulus tinkerbirds adapt their song when exposed to continuous low-frequency noise from ocean surf. We show that dominant frequency increases the closer birds are to the coast in at least two species, indicating that ocean surf sound may apply a selective pressure on songs. Tinkerbirds adapt their songs by increasing dominant frequency to avoid masking by ambient noise, therefore improving long-range communication. Our study provides evidence that natural ambient noise affects vocalisations in birds whose songs develop innately. We believe that our results can also be extrapolated in the context of anthropogenic noise pollution, hence providing a baseline for the study of the effects of low-frequency ambient noise on birds that lack vocal learning.
Berezinskii-Kosterlitz-Thouless phase induced by dissipating quasisolitons
Creators: name: Gawryluk, Krzysztof
name: Brewczyk, Mirosław
Publisher: name: arXiv
Year: 2020
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We theoretically study the sound propagation in a two-dimensional weakly interacting uniform Bose gas. Using the classical fields approximation we analyze in detail the properties of density waves generated both in a weak and strong perturbation regimes. While in the former case density excitations can be described in terms of hydrodynamic or collisionless sound, the strong disturbance of the system results in a qualitatively different response. We identify observed structures as quasisolitons and uncover their internal complexity for strong perturbation case. For this regime quasisolitons break into vortex pairs as time progresses, eventually reaching an equilibrium state. We find this state, characterized by only fluctuating in time averaged number of pairs of opposite charge vortices and by appearance of a quasi-long-range order, as the Berezinskii-Kosterlitz-Thouless (BKT) phase.
Emptiness Formation Probability for the Anisotropic XY Spin Chain in a Magnetic Field
Creators: name: Abanov, Alexander G.
name: Franchini, Fabio
Publisher: name: arXiv
Year: 2003
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We study an asymptotic behavior of the probability of formation of a ferromagnetic string (referred to as EFP) of length "n" in a ground state of the one-dimensional anisotropic XY model in a transversal magnetic field as n goes to infinity. We find that it is exponential everywhere in the phase diagram of the XY model except at the critical lines where the spectrum is gapless. One of those lines corresponds to the isotropic XY model where EFP decays in a Gaussian way, as was shown in cond-mat/0106062. The other line is at the critical value of the magnetic field. There, we show that EFP is still exponential but acquires a non-trivial power-law prefactor with a universal exponent.
description: 15 pages, 3 figures, elsart document class
Stability of $π$ junction configurations in ferromagnet-superconductor heterostructures
Creators: name: Halterman, Klaus
name: Valls, Oriol T.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We investigate the stability of possible order parameter configurations in clean layered heterostructures of the $SFS...FS$ type, where $S$ is a superconductor and $F$ a ferromagnet. We find that for most reasonable values of the geometric parameters (layer thicknesses and number) and of the material parameters (such as magnetic polarization, wavevector mismatch, and oxide barrier strength) several solutions of the {\it self consistent} microscopic equations can coexist, which differ in the arrangement of the sequence of ``0'' and ``$π$'' junction types (that is, with either same or opposite sign of the pair potential in adjacent $S$ layers). The number of such coexisting self consistent solutions increases with the number of layers. Studying the relative stability of these configurations requires an accurate computation of the small difference in the condensation free energies of these inhomogeneous systems. We perform these calculations, starting with numerical self consistent solutions of the Bogoliubov-de Gennes equations. We present extensive results for the condensation free energies of the different possible configurations, obtained by using efficient and accurate numerical methods, and discuss their relative stabilities. Results for the experimentally measurable density of states are also given for different configurations and clear differences in the spectra are revealed. Comprehensive and systematic results as a function of the relevant parameters for systems consisting of three and seven layers (one or three junctions) are given, and the generalization to larger number of layers is discussed.
description: 17 pages, including 14 Figures. Higher resolution figures available from the authors
Bubbling and regularity issues in geometric non-linear analysis
Creators: name: Rivière, Tristan
Publisher: name: arXiv
Year: 2003
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35D10, 35J20, 35J60, 49Q20, 58E15, 58E20

description: Numerous elliptic and parabolic variational problems arising in physics and geometry (Ginzburg-Landau equations, harmonic maps, Yang-Mills fields, Omega-instantons, Yamabe equations, geometric flows in general...) possess a critical dimension in which an invariance group (similitudes, conformal groups) acts. This common feature generates, in all these different situations, the same non-linear effect. One observes a strict splitting in space between an almost linear regime and a dominantly non-linear regime which has two major characteristics : it requires a quantized amount of energy and arises along rectifiable objects of special geometric interest (geodesics, minimal surfaces, J-holomorphic curves, special Lagrangian manifolds, mean-curvature flows...).
An Improved RF Cavity Search for Halo Axions
Creators: name: Asztalos, S. J.
name: Bradley, R. F.
name: Duffy, L.
name: Hagmann, C.
name: Kinion, D.
name: Moltz, D. M.
name: Rosenberg, L. J
name: Sikivie, P.
name: Stoeffl, W.
name: Sullivan, N. S.
name: Tanner, D. B.
name: van Bibber, K.
name: Yu, D. B.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The axion is a hypothetical elementary particle and cold dark matter candidate. In this RF cavity experiment, halo axions entering a resonant cavity immersed in a static magnetic field convert into microwave photons, with the resulting photons detected by a low-noise receiver. The ADMX Collaboration presents new limits on the axion-to-photon coupling and local axion dark matter halo mass density from a RF cavity axion search in the axion mass range 1.9-2.3 microeV, broadening the search range to 1.9-3.3 microeV. In addition, we report first results from an improved analysis technique.
description: 5 pages, submitted to Physical Review D rapid communications