Additional file 1 of Focal liver lesions: multiparametric microvasculature characterization via super-resolution ultrasound imaging
Creators: name: Zeng, Qian-Qian
name: An, Shi-Zhe
name: Chen, Chao-Nan
name: Wang, Zhen
name: Liu, Jia-Cheng
name: Wan, Ming-Xi
name: Zong, Yu-Jin
name: Jian, Xiao-Hua
name: Yu, Jie
name: Liang, Ping
Publisher: name: figshare
Year: 2024
Subjects: Space Science
Physical Sciences not elsewhere classified
Medicine
Cell Biology
Chemical Sciences not elsewhere classified
Cancer

description: Additional file 1: Supplementary Table S1 Modified for the ultrafast imaging mode in Resona 7. Supplementary Figure S1: Display the five different manually cross-sectioned ROI of the same SR-US density map with Fig. 4. The vessel size measured as the full width at half-maximum of the amplitude distribution of the Gaussian fit curve on SR-US image and corresponding CE-PD image in each selected ROI. CE-PD = contrast-enhanced power Doppler, SR-US = super-resolution ultrasound, ROI = region of interest. Supplementary Table S2: The cross-section measurement of CE-PD mode and SR-US mode in each selected ROI. Supplementary Figure S2: SR-US parameter maps of an atypical liver metastasis. (a) The SR-US density map indicates that the microvascular structure of the lesion exhibits chaotic distribution throughout the lesion area, displaying an irregularly distributed density pattern. The color bar corresponds to the normalized number of localized microbubbles. (b) The SR-US velocity map indicates that the central vascular velocity of the lesion is marginally greater than that of the periphery; however, it does not meet the criteria outlined in the study for "at least two vessels with distinctly faster blood flow." Additionally, the overall blood flow velocity of the lesion remains low, leading to its classification as a low-speed supplying pattern. The color bar corresponds to speed (in mm/s). (c) The SR-US direction map displays a complex pattern of diverse and intersecting flow directions, characterized as a mixed direction pattern. The color bar represents blood flow direction (red and blue indicate flow toward and away from the transducer, respectively) and the normalized number of localized microbubbles. Horizontal scale: 5mm. Supplementary Figure S3: SR-US parameter maps of an atypical focal nodular hyperplasia. (a) The SR-US density map indicates that the microvascular structure of the lesion is abundant and uniformly distributed across the lesion area, presenting a well-distributed density pattern. The color bar corresponds to the normalized number of localized microbubbles. (b) The SR-US velocity map indicates that the lesion exhibits a high overall vascular velocity, characterized by a high-speed feeding pattern; however, no central "radial" trunk vessels are discernible. The color bar corresponds to speed (in mm/s). (c) The SR-US direction map displays intersecting and overlapping blood flow directions, characterized as a mixed direction pattern. The color bar represents blood flow direction (red and blue indicate flow toward and away from the transducer, respectively) and the normalized number of localized microbubbles. Horizontal scale: 2mm. Supplementary Figure S4: SR-US parameter maps of a hepatocellular carcinoma resembling focal nodular hyperplasia. (a) The SR-US density map reveals that the microvascular structure of the lesion is somewhat sparse but exhibits a relatively uniform distribution across the lesion area, thus is classified as a well-distributed density pattern. The color bar corresponds to the normalized number of localized microbubbles. (b) The SR-US velocity map shows that the central vascular flow velocity of the lesion is comparatively high, presenting a high-speed feeding pattern. The color bar corresponds to speed (in mm/s). (c) The SR-US direction map reveals the presence of prominent central vessels exhibiting a centrifugal flow direction, thereby indicating a classification as a centrifugal directional pattern. The color bar represents blood flow direction (red and blue indicate flow toward and away from the transducer, respectively) and the normalized number of localized microbubbles. Horizontal scale: 2mm. Supplementary Figure S5: SR-US parameter maps of a hepatocellular carcinoma resembling liver metastasis. (a) The SR-US density map reveals that the microvascular structure of the lesion is predominantly located in the peripheral region, with a noticeable absence of microvascular structure in the central area, resulting in a peripheral-distributed density pattern. The color bar corresponds to the normalized number of localized microbubbles. (b) The SR-US velocity map shows that the blood flow velocity within the lesion is comparatively high, presenting a high-speed feeding pattern. The color bar corresponds to speed (in mm/s). (c) The SR-US direction map indicates that vessels with high velocity exhibit blood flow directed toward the transducer, thereby being categorized as a eccentric direction pattern. The color bar represents blood flow direction (red and blue indicate flow toward and away from the transducer, respectively) and the normalized number of localized microbubbles. Horizontal scale: 5mm