cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sarcoglycans and integrins in masseter muscle of baboons: an immunohistochemical and molecular study
Creators: name: Anastasi, Giuseppe
name: Favaloro, Angelo
name: Di Mauro, Debora
name: Rizzo, Giuseppina
name: Speciale, Francesco
name: Santoro, Giuseppe
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2013
Subjects: Baboons; sarcoglycans; integrins

description: The sarcoglycans subcomplex consists of six transmenbrane proteins (α,β,δ,γ,ε,ζ), functionally connected by a bidirectional signalling with integrins, transmembrane receptors that play a key role in cell adhesion and differentiation. b1D-integrin is detected only in skeletal and cardiac muscle, while low amounts of b1A were detected in striated muscles. b1D was associated with α7A and α7B in adult skeletal. Although numerous studies have been carried out on these proteins in many muscle types, insufficient data exist on their behaviour in masseter muscle, an highly unusual muscle for the presence, in addition to slow and fast fibers, of hybrid fibers types important for the specific functional demands of masseter. Our studies on normal human masseter muscle and on masseter of subjects with right crossbite, showed that integrins play a role in the functional activity of muscle and in the optimization of contractile forces. Also, we studied these proteins in masseter of chimpanzees, alpha and non-alpha male subjects. These results have shown a different quantitative composition of integrins in alpha male in respect to non-alpha male hypothesizing a key role for integrins and sarcoglycans in the determination of contraction force. Here, we analyzed masseter muscle obtained from baboons, animals similar in phylogeny with humans and chimpanzees, individuating subjects with high and low dominance. Our immunohistochemical results, confirmed also by Western Blotting analysis, show that, in high dominance subjects, stainings for sarcoglycans and integrins were normal; interestingly, in low dominance subjects stainings for these proteins were normal, lower or absent in different fibers of the same microscopic field. Thus, preliminary analysis on cell cultures of myoblasts and myotubes, at different days of differentiation, immunolabelled with antibodies against sarcoglycans and integrins, have demonstrated a similar behaviour, showing cells with an higher or lower staining for these proteins. In our opinion, these results provide the first suggestion that integrins and sarcoglycans in masseter muscle play a key role regulating muscular functional activity and allowing the optimization of contractile forces of this muscle.
description: Italian Journal of Anatomy and Embryology, Vol 117, No 2 (Supplement) 2012
title: ÐÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð¾Ðµ Ð¾Ð±ÐµÑÐ¿ÐµÑÐµÐ½Ð¸Ðµ Ð´Ð»Ñ ÑÐ´Ð°Ð»ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð´Ð¾ÑÑÑÐ¿Ð° Ðº ÑÐ°Ð±Ð¾ÑÐµÐ¼Ñ ÑÑÐ¾Ð»Ñ Ñ Ð¼Ð¾Ð±Ð¸Ð»ÑÐ½Ð¾Ð³Ð¾ ÑÐµÐ»ÐµÑÐ¾Ð½Ð° Ð¿Ð¾Ð´ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸ÐµÐ¼ ÑÐ¸ÑÑÐµÐ¼Ñ Android
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
Creators: name: Ð¡Ð¼Ð¸ÑÐ½Ð¾Ð², ÐÐ½Ð´ÑÐµÐ¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2018
Subjects: ÐºÐ»Ð¸ÐµÐ½Ñ-ÑÐµÑÐ²ÐµÑÐ½Ð°Ñ Ð°ÑÑ Ð¸ÑÐµÐºÑÑÑÐ°
TCP
IPv4
Java
C++
Android
XML
Windows
socket
Android Studio
Visual Studio

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Ambient Isotopic Meshing of Implicit Algebraic Surface with Singularities
Creators: name: Cheng, Jin-San
name: Gao, Xiao-Shan
name: Li, Jia
Publisher: name: arXiv
Year: 2009
Subjects: subject: Computational Geometry (cs.CG)
subject: Graphics (cs.GR)
subject: FOS: Computer and information sciences
subject: G.1.2

description: A complete method is proposed to compute a certified, or ambient isotopic, meshing for an implicit algebraic surface with singularities. By certified, we mean a meshing with correct topology and any given geometric precision. We propose a symbolic-numeric method to compute a certified meshing for the surface inside a box containing singularities and use a modified Plantinga-Vegter marching cube method to compute a certified meshing for the surface inside a box without singularities. Nontrivial examples are given to show the effectiveness of the algorithm. To our knowledge, this is the first method to compute a certified meshing for surfaces with singularities.
description: 34 pages, 17 Postscript figures
Short-range incommensurate magnetic order near the superconducting phase boundary in Fe(1+d)Te(1-x)Se(x)
Creators: name: Wen, Jinsheng
name: Xu, Guangyong
name: Xu, Zhijun
name: Lin, Zhi Wei
name: Li, Qiang
name: Ratcliff, W.
name: Gu, Genda
name: Tranquada, J. M.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We performed elastic neutron scattering and magnetization measurements on Fe(1.07)Te(0.75)Se(0.25) and FeTe(0.7)Se(0.3). Short-range incommensurate magnetic order is observed in both samples. In the former sample with higher Fe content, a broad magnetic peak appears around (0.46,0,0.5) at low temperature, while in FeTe(0.7)Se(0.3) the broad magnetic peak is found to be closer to the antiferromagnetic (AFM) wave-vector (0.5,0,0.5). The incommensurate peaks are only observed on one side of the AFM wave-vector for both samples, which can be modeled in terms of an imbalance of ferromagnetic/antiferromagnetic correlations between nearest-neighbor spins. We also find that with higher Se (and lower Fe) concentration, the magnetic order becomes weaker while the superconducting temperature and volume increase.
description: Version as appeared in PRB
Vancouver's missing middle
Creators: name: Beaudreau, James Alfred
Publisher: name: The University of British Columbia
Year: 2015

description: Vancouver, British Columbia is experiencing rapid growth. The city currently faces difficult questions about how it will grow, and how to ensure this growth is sustainable. Some kind of intensification of residential land uses will undoubtedly need to be part of the strategy for increasing the supply of housing in the city, but questions remain about how this intensification should be carried out. This report compares the built form of Vancouver's low-density, single-family communities to older and more established neighbourhoods in cities in both North America and Europe. The purpose of this exercise is to understand how the built form of the city, such as the street patterns and types of buildings, affect the level of density. This report finds that there is a significant amount of land in Vancouver that could be redeveloped to meet future housing needs.
Breast cancer stroma influences the migratory behaviour of epithelial malignant cells: the role of secreted hepatocyte growth factor
Creators: name: Angelucci, Cristiana
name: Maulucci, Giuseppe
name: Colabianchi, Anna
name: Iacopino, Fortunata
name: Maiorana, Alessandro
name: Palmieri, Valentina
name: De Spirito, Marco
name: Di Leone, Alba
name: Masetti, Riccardo
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2014

description: In breast tumor, interactions occurring between malignant cells and stromal microenvironment heavily influence various aspects of cancer biology. We recently reported that this cross-talk affects structural and functional features correlated with the invasive phenotype of breast cancer cells by co-culturing mammary cancer cells exhibiting different degrees of metastatic potential (MDA-MB-231>MCF-7) with fibroblasts, particularly those isolated from breast tumor stroma (cancer-associated fibroblasts, CAFs). In the present study, we aimed to elucidate some aspects of the epithelium-stroma interaction, related to two linked CAF-triggered effects we previously described: a) increase in cancer cell plasma membrane fluidity; b) increase in speed and directness of cancer cell migration. Thus, we tested the effect of fibroblast/breast cancer cell co-culturing on the expression of Stearoyl-CoA desaturase 1 (SCD1), the main enzyme regulating the fatty acid membrane composition whose up-regulation has been reported in different cancer cells, generally leading to loosely packed membranes. Western blot analysis revealed a dramatic CAF-promoted increase in SCD1 expression in both MCF-7 and MDA-MB-231 cells. Quantitative real-time PCR demonstrated similar variations in the SCD1 transcript levels. With the aim of clarifying the possible role of soluble factors in the CAF-induced increase in speed and directness of cancer cell migration, we performed co-culture assays in presence of a neutralizing antibody against hepatocyte growth factor (HGF) which is released by CAFs and notoriously affects cancer cell motility. We demonstrated that speed and directness increases were strongly reduced or completely abolished by the addition of the anti-HGF neutralizing antibody to the culture medium. These results provide new insights in understanding the role of CAFs, the main host stromal component of breast cancer, in promoting the tumor cell invasive attitude and may help in defining further promising therapeutic targets.
description: Italian Journal of Anatomy and Embryology, Vol 118, No 2 (Supplement) 2013
Automatic polishing process of plastic injection molds on a 5-axis milling center
Creators: name: Pessoles, Xavier
name: Tournier, Christophe
Publisher: name: arXiv
Year: 2010
Subjects: subject: General Physics (physics.gen-ph)
subject: FOS: Physical sciences

description: The plastic injection mold manufacturing process includes polishing operations when surface roughness is critical or mirror effect is required to produce transparent parts. This polishing operation is mainly carried out manually by skilled workers of subcontractor companies. In this paper, we propose an automatic polishing technique on a 5-axis milling center in order to use the same means of production from machining to polishing and reduce the costs. We develop special algorithms to compute 5-axis cutter locations on free-form cavities in order to imitate the skills of the workers. These are based on both filling curves and trochoidal curves. The polishing force is ensured by the compliance of the passive tool itself and set-up by calibration between displacement and force based on a force sensor. The compliance of the tool helps to avoid kinematical error effects on the part during 5-axis tool movements. The effectiveness of the method in terms of the surface roughness quality and the simplicity of implementation is shown through experiments on a 5-axis machining center with a rotary and tilt table.
A Multi-Precision Quadratic Regularization Method for Unconstrained Optimization with Rounding Error Analysis
Creators: name: Monnet, Domnique
name: Orban, Dominique
Publisher: name: arXiv
Year: 2023
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics

description: We propose a multi-precision extension of the Quadratic Regularization (R2) algorithm that enables it to take advantage of low-precision computations, and by extension to decrease energy consumption during the solve. The lower the precision in which computations occur, the larger the errors induced in the objective value and gradient, as well as in all other computations that occur in the course of the iterations. The Multi-Precision R2 (MPR2) algorithm monitors the accumulation of rounding errors with two aims: to provide guarantees on the result of all computations, and to permit evaluations of the objective and its gradient in the lowest precision possible while preserving convergence properties. MPR2's numerical results show that single precision offers enough accuracy for more than half of objective evaluations and most of gradient evaluations during the algorithm's execution. However, MPR2 fails to converge on several problems of the test set for which double precision does not offer enough precision to ensure the convergence conditions before reaching a first order critical point. That is why we propose a practical version of MPR2 with relaxed conditions which converges for almost as many problems as R2 and potentially enables to save about 50 % time and 60% energy for objective evaluation and 50 % time and 70% energy for gradient evaluation.
Rings and arcs around evolved stars -- III. Physical conditions of the ring-like structures in the planetary nebula IC 4406 revealed by MUSE
Creators: name: Ramos-Larios, G.
name: Toalá, J. A.
name: Rodríguez-González, J. B.
name: Guerrero, M. A.
name: Gómez-González, V. M. A.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present the analysis of Very Large Telescope (VLT) Multi Unit Spectroscopic Explorer (MUSE) observations of the planetary nebula (PN) IC 4406. MUSE images in key emission lines are used to unveil the presence of at least 5 ring-like structures North and South of the main nebula of IC 4406. MUSE spectra are extracted from the rings to unambiguously assess for the first time in a PN their physical conditions, electron density (ne) and temperature (Te). The rings are found to have similar Te than the rim of the main nebula, but smaller ne. Ratios between different ionic species suggest that the rings of IC 4406 have a lower ionization state than the main cavity, in contrast to what was suggested for the rings in NGC6543, the Cat's Eye Nebula.
description: 8 pages, 5 figures, 2 tables. Accepted for publication in MNRAS
Free-streaming approximation in early dynamics of relativistic heavy-ion collisions
Creators: name: Broniowski, Wojciech
name: Florkowski, Wojciech
name: Chojnacki, Mikolaj
name: Kisiel, Adam
Publisher: name: arXiv
Year: 2008
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We investigate an approximation to early dynamics in relativistic heavy-ion collisions, where after formation the partons are free streaming and around the proper time of 1 fm/c undergo a sudden equilibration described in terms of the Landau matching condition. We discuss physical and formal aspects of this approach. In particular, we show that initial azimuthally asymmetric transverse flow develops for non-central collisions as a consequence of the sudden equilibration. Moreover, the energy-momentum tensor from the free-streaming stage matches very smoothly to the form used in the transverse hydrodynamics, whereas matching to isotropic hydrodynamics requires a more pronounced change in the energy-momentum tensor. After the hydrodynamic phase statistical hadronization is carried out with the help of THERMINATOR. The physical results for the transverse-momentum spectra, the elliptic-flow, and the Hanbury-Brown--Twiss correlation radii, including the ratio R_out/R_side as well as the dependence of the radii on the azimuthal angle (azHBT), are properly described within our approach. The agreement is equally good for a purely hydrodynamic evolution started at an early proper time of 0.25 fm/c, or for the free streaming started at that time, followed by the sudden equilibration at tau ~1 fm/c and then by perfect hydrodynamics. Thus, the inclusion of free streaming allows us to delay the start of hydrodynamics to more realistic times of the order of 1 fm/c.
description: 10 pages, 12 figures
title: Ð¡ÑÑÐ°ÑÐµÐ³Ð¸Ñ ÑÐ¾ÑÐ¸Ð°Ð»ÑÐ½Ð¾-ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ¾Ð³Ð¸Ð½Ð¾Ð², ÐÐµÐ¾ÑÐ³Ð¸Ð¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2018
Subjects: ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ
ÑÑÑÐ°ÑÐµÐ³Ð¸ÑÐµÑÐºÐ¸Ð¹ Ð¼ÐµÐ½ÐµÐ´Ð¶Ð¼ÐµÐ½Ñ
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description: ÐÐ±ÑÐµÐºÑÐ¾Ð¼ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐ²Ð»ÑÐµÑÑÑ Ð¾Ð±ÑÐµÑÑÐ²Ð¾ Ñ Ð¾Ð³ÑÐ°Ð½Ð¸ÑÐµÐ½Ð½Ð¾Ð¹ Ð¾ÑÐ²ÐµÑÑÑÐ²ÐµÐ½Ð½Ð¾ÑÑÑÑ Â«Ð¢ÑÐ°Ð¼Ð¿Ð»Ð¸Ð½-ÑÑÑÐ¾Ð¹Â». ÐÑÐ¿Ð¾Ð»Ð½ÐµÐ½ Ð°Ð½Ð°Ð»Ð¸Ð· ÑÐµÐºÑÑÐµÐ³Ð¾ ÑÐ¾ÑÐ¸Ð°Ð»ÑÐ½Ð¾-ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐ¾ÑÑÐ¾ÑÐ½Ð¸Ñ Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ Ð¸ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ñ ÑÑÑÐ°ÑÐµÐ³Ð¸Ñ Ð¸ ÑÐµÐºÐ¾Ð¼ÐµÐ½Ð´Ð°ÑÐ¸Ð¸ Ð´Ð»Ñ Ð¿Ð¾Ð²ÑÑÐµÐ½Ð¸Ñ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ.
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Silybin enhances mitochondrial function and inhibits NFkB activation in murine nonalcoholic fatty liver disease
Creators: name: Cappello, Francesco
name: Li Volti, Giovanni
name: Salamone, Federico
name: Marino-Gammazza, Antonella
name: Catanese, Patrizia
name: Pitruzzella, Alessandro
name: Rizzuto, Luigi
name: Macaluso, Filippo
name: Campanella, Claudia
name: David, Sabrina
name: Di Felice, Valentina
name: Marcianò, Vito
name: Peri, Giovanni
name: Zummo, Giovanni
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2010
Subjects: Liver histology; hepatic lipid homeostasis; mitochondrial function; oxidative-nitrosative stress

description: Italian Journal of Anatomy and Embryology, Vol 115, No 1/2 (Supplement) 2010
Additional file 1 of Clinical utility of aVR lead T-wave in electrocardiogram of patients with ST-elevation myocardial infarction
Creators: name: Kazemi, Babak
name: Sadat-Ebrahimi, Seyyed-Reza
name: Ranjbar, Abdolmohammad
name: Akbarzadeh, Fariborz
name: Sadaie, M. Reza
name: Safaei, Naser
name: Esmaeil zadeh-Saboor, Mehdi
name: Sohrabi, Bahram
name: Ghaffari, Samad
Publisher: name: figshare
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Additional file 1. The supplemental tables and figures.
Synthetic solar cycle for active regions violating the Hale's polarity law
Creators: name: Zhukova, A.
name: Khlystova, A.
name: Abramenko, V.
name: Sokoloff, D.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Long observational series for bipolar active regions (ARs) provide significant information about the mutual transformation of the poloidal and toroidal components of the global solar magnetic field. The direction of the toroidal field determines the polarity of leading sunspots in ARs in accordance with the Hale's polarity law. The vast majority of bipolar ARs obey this regularity, whereas a few percent of ARs have the opposite sense of polarity (anti-Hale ARs). However, the study of these ARs is hampered by their poor statistics. The data for five 11-year cycles (16-18 and 23,24) were combined here to compile a synthetic cycle of unique time length and latitudinal width. The synthetic cycle comprises data for 14838 ARs and 367 of them are the anti-Hale ARs. A specific routine to compile the synthetic cycle was demonstrated. We found that, in general, anti-Hale ARs follow the solar cycle and are spread throughout the time-latitude diagram evenly, which implies their fundamental connection with the global dynamo mechanism and the toroidal flux system. The increase in their number and percentage occurs in the second part of the cycle, which is in favour of their contribution to the polar field reversal. The excess in the anti-Hale ARs percentage at the edges of the butterfly diagram and near an oncoming solar minimum (where the toroidal field weakens) might be associated with strengthening of the influence of turbulent convection and magnetic field fluctuations on the arising flux tubes. The evidence of the misalignment between the magnetic and heliographic equators is also found.
description: 7 pages, 7 figures
title: Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¸Ð½ÑÑÑÑÐ¼ÐµÐ½ÑÐ°ÑÐ¸Ñ Ð¾ÑÐµÐ½ÐºÐ¸ ÐºÐ°ÑÐµÑÑÐ²Ð° Ð¿ÐµÑÐµÐ²Ð¾Ð´Ð¾Ð² Ð² ÑÑÐµÑÐµ Ð¼ÐµÐ´Ð¸ÑÐ¸Ð½Ñ Ð¸ ÑÑÐ¸ÑÐ¿ÑÑÐ´ÐµÐ½ÑÐ¸Ð¸
title: Ð¼Ð°Ð³Ð¸ÑÑÐµÑÑÐºÐ°Ñ Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ñ
titleType: Subtitle
Creators: name: Ð¡ÑÐ°ÑÐ¾ÑÐµÐ»ÑÑÐºÐ°Ñ, ÐÐ°ÑÐ°Ð»Ð¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: ÐºÐ°ÑÐµÑÑÐ²Ð¾ Ð¿ÐµÑÐµÐ²Ð¾Ð´Ð°
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description: Ð Ð¼Ð°Ð³Ð¸ÑÑÐµÑÑÐºÐ¾Ð¹ Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ð¸ Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ð¾ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¿ÑÐ¾Ð±Ð»ÐµÐ¼Ñ Ð¾ÑÐµÐ½ÐºÐ¸ ÐºÐ°ÑÐµÑÑÐ²Ð° Ð¿ÐµÑÐµÐ²Ð¾Ð´Ð°. ÐÐ²ÑÐ¾ÑÐ¾Ð¼ Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÑÑÑÑÑ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÐµ ÑÐµÐ¾ÑÐµÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð¿Ð¾Ð´ÑÐ¾Ð´Ñ Ðº Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ ÐºÐ°ÑÐµÑÑÐ²Ð° Ð¿ÐµÑÐµÐ²Ð¾Ð´Ð° Ð¸ Ðº ÑÐ¸ÑÑÐµÐ¼Ð°ÑÐ¸Ð·Ð°ÑÐ¸Ð¸ Ð¿ÐµÑÐµÐ²Ð¾Ð´ÑÐµÑÐºÐ¸Ñ Ð¾ÑÐ¸Ð±Ð¾Ðº, Ð¿ÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð¼ÐµÑÐ¾Ð´Ð¸ÐºÐ¸ Ð¿Ð¾ Ð¾ÑÐµÐ½ÐºÐµ ÐºÐ°ÑÐµÑÑÐ²Ð° Ð¿ÐµÑÐµÐ²Ð¾Ð´Ð°. ÐÐ¾Ð»ÑÑÐ¾Ðµ Ð²Ð½Ð¸Ð¼Ð°Ð½Ð¸Ðµ Ð² ÑÐ°Ð±Ð¾ÑÐµ ÑÐ´ÐµÐ»ÑÐµÑÑÑ Ðº ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐµ Ð¸Ð½ÑÑÑÑÐ¼ÐµÐ½ÑÐ°ÑÐ¸Ñ Ð¾ÑÐµÐ½ÐºÐ¸ ÐºÐ°ÑÐµÑÑÐ²Ð° Ð¿ÐµÑÐµÐ²Ð¾Ð´Ð° Ð² ÑÑÐµÑÐµ Ð¼ÐµÐ´Ð¸ÑÐ¸Ð½Ñ Ð¸ ÑÑÐ¸ÑÐ¿ÑÑÐ´ÐµÐ½ÑÐ¸Ð¸. ÐÐ»Ñ ÑÑÐ¾Ð³Ð¾ Ð¸Ð·ÑÑÐ°Ð»Ð¸ÑÑ ÑÑÐ¸Ð»Ð¸ÑÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸, Ð½Ð°Ð¸Ð±Ð¾Ð»ÐµÐµ ÑÐ°ÑÑÐ¾ÑÐ½ÑÐµ Ð¿ÐµÑÐµÐ²Ð¾Ð´ÑÐµÑÐºÐ¸Ðµ Ð¾ÑÐ¸Ð±ÐºÐ¸, Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸ Ð¿ÐµÑÐµÐ²Ð¾Ð´Ð° Ð´Ð»Ñ ÑÐµÐºÑÑÐ¾Ð² Ð´Ð°Ð½Ð½ÑÑ ÑÐµÐ¼Ð°ÑÐ¸Ðº. Ð ÐºÐ°ÑÐµÑÑÐ²Ðµ Ð¾ÑÐ½Ð¾Ð²Ð½Ð¾Ð³Ð¾ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐ° Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð²ÑÑÑÑÐ¿Ð°ÐµÑ ÑÐ¾Ð·Ð´Ð°Ð½Ð½Ð°Ñ Ð² ÑÐ°Ð¼ÐºÐ°Ñ Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ ÑÐ¸ÑÑÐµÐ¼Ð° Ð¾ÑÐµÐ½ÐºÐ¸ ÐºÐ°ÑÐµÑÑÐ²Ð° ÑÐµÐºÑÑÐ¾Ð² Ð¼ÐµÐ´Ð¸ÑÐ¸Ð½ÑÐºÐ¾Ð¹ Ð¸ ÑÑÐ¸Ð´Ð¸ÑÐµÑÐºÐ¾Ð¹ ÑÐµÐ¼Ð°ÑÐ¸ÐºÐ¸, ÐºÐ¾ÑÐ¾ÑÐ°Ñ Ð±ÑÐ»Ð° Ð°Ð¿ÑÐ¾Ð±Ð¸ÑÐ¾Ð²Ð°Ð½Ð° Ð½Ð° 21 Ð¿ÐµÑÐµÐ²Ð¾Ð´Ðµ, Ð²ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð½Ð¾Ð¼ ÑÑÑÐ´ÐµÐ½ÑÐ°Ð¼Ð¸-Ð¿ÐµÑÐµÐ²Ð¾Ð´ÑÐ¸ÐºÐ°Ð¼Ð¸ Ð¿ÐµÑÐ²Ð¾Ð³Ð¾ Ð¸ Ð²ÑÐ¾ÑÐ¾Ð³Ð¾ ÐºÑÑÑÐ¾Ð² Ð¼Ð°Ð³Ð¸ÑÑÑÐ°ÑÑÑÑ Ð¿Ð¾ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ Â«ÐÐ¸Ð½Ð³Ð²Ð¸ÑÑÐ¸ÐºÐ°Â» ÐÑÐ¼Ð°Ð½Ð¸ÑÐ°ÑÐ½Ð¾Ð³Ð¾ Ð¸Ð½ÑÑÐ¸ÑÑÑÐ° Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¾Ð³Ð¾ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑÐ° ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾. ÐÐ¿ÑÐ¾Ð±Ð°ÑÐ¸Ñ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð»Ð°, ÑÑÐ¾ Ð¾ÑÐµÐ½ÐºÐ° ÐºÐ°ÑÐµÑÑÐ²Ð° Ð¿ÐµÑÐµÐ²Ð¾Ð´Ð¾Ð² Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð´Ð°Ð½Ð½Ð¾Ð³Ð¾ Ð¸Ð½ÑÑÑÑÐ¼ÐµÐ½ÑÐ°ÑÐ¸Ñ ÑÐ²Ð»ÑÐµÑÑÑ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾Ð¹ Ð¸ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐ¸Ð²Ð½Ð¾Ð¹. Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð½ÑÐ¹ Ð² ÑÐ°Ð¼ÐºÐ°Ñ Ð¼Ð°Ð³Ð¸ÑÑÐµÑÑÐºÐ¾Ð¹ Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ð¸ Ð¸Ð½ÑÑÑÑÐ¼ÐµÐ½ÑÐ°ÑÐ¸Ð¹ Ð¾ÑÐµÐ½ÐºÐ¸ ÐºÐ°ÑÐµÑÑÐ²Ð° Ð¿ÐµÑÐµÐ²Ð¾Ð´Ð° Ð² ÑÑÐµÑÐµ Ð¼ÐµÐ´Ð¸ÑÐ¸Ð½Ñ Ð¸ ÑÑÐ¸ÑÐ¿ÑÑÐ´ÐµÐ½ÑÐ¸Ð¸ Ð¼Ð¾Ð¶Ð½Ð¾ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°ÑÑ Ð¿ÑÐ¸ Ð¾ÑÐµÐ½ÐºÐµ ÑÑÑÐ´ÐµÐ½ÑÐµÑÐºÐ¸Ñ Ð¸ Ð¿ÑÐ¾ÑÐµÑÑÐ¸Ð¾Ð½Ð°Ð»ÑÐ½ÑÑ Ð¿ÐµÑÐµÐ²Ð¾Ð´Ð¾Ð².
Self-Convergence of Radiatively Cooling Clumps
Creators: name: Yirak, Kristopher
name: Frank, Adam
name: Cunningham, Andrew J.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Numeric convergence studies demonstrate that the evolution of an adiabatic clump is well-captured by roughly 100 cells per clump radius. The presence of radiative cooling, however, imposes limits on the problem due to the removal of thermal energy. Numerical studies which include radiative cooling typically adopt the 100--200 cells per clump radius resolution. In this paper we present the results of a convergence study for radiatively cooling clumps undertaken over a broad range of resolutions, from 12 to 1,536 cells per clump radius, employing adaptive mesh refinement (AMR) in a 2D axisymmetric geometry ("2.5D"). We also provide a fully 3D simulation, at 192 cells per clump radius, which supports our 2.5D results. We find no appreciable self-convergence at ~100 cells per clump radius as small-scale differences owing to increasingly resolving the "cooling length" have global effects. We therefore conclude that self-convergence is an insufficient criterion to apply on its own when addressing the question of sufficient resolution for radiatively cooled shocked clump simulations. We suggest the adoption of alternate criteria to support a statement of sufficient resolution, such as the demonstration of adequate resolution of the cooling layers behind shocks. We discuss an associated refinement criteria for AMR codes.
description: 24 pages, 7 figures. Submitted to the Astrophysical Journal
title: ÐÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ¸Ð¹ ÐºÑÑÑ Ð¾Ð±ÑÑÐµÐ½Ð¸Ñ ÑÑÑÑÐºÐ¾Ð¼Ñ ÑÐ·ÑÐºÑ ÐºÐ°Ðº Ð¸Ð½Ð¾ÑÑÑÐ°Ð½Ð½Ð¾Ð¼Ñ Ð² Ð¼Ð½Ð¾Ð³Ð¾Ð¿ÑÐ¾ÑÐ¸Ð»ÑÐ½Ð¾Ð¼ Ð²ÑÐ·Ðµ
title: ÑÑÐµÐ±Ð½Ð¾Ðµ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ðµ
titleType: Subtitle
Creators: name: ÐÐ»Ð¼Ð°Ð·Ð¾Ð²Ð°, ÐÐ°Ð´ÐµÐ¶Ð´Ð°
name: Ð ÑÐ±ÑÐ¾Ð²Ð°, ÐÐ½Ð½Ð°
name: ÐÑÑÐ»Ð¾Ð²Ð°, ÐÐ»ÐµÐ½Ð°
name: ÐÐ´Ð¸Ð½Ð¾ÐºÐ°Ñ, ÐÐ°ÑÐ¸Ñ
name: ÐÐ°ÑÐ¸Ð½Ð¾Ð²Ð°, ÐÐ°ÑÐ¸Ð½Ð°
name: Ð¡Ð¼Ð¾Ð»ÑÑÐºÐ°Ñ, ÐÐ°ÑÐ°Ð»Ð¸Ñ
Publisher: name: ÐÐÐÐÐ¢ÐÐ¥-ÐÐ ÐÐ¡Ð¡
Year: 2020
Subjects: ÑÑÑÑÐºÐ¸Ð¹ ÑÐ·ÑÐº
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ÑÑÐµÐ±Ð½Ð¸ÐºÐ¸ Ð¸ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ñ Ð´Ð»Ñ Ð¸Ð½Ð¾ÑÑÑÐ°Ð½ÑÐµÐ²

description: Ð£ÑÐµÐ±Ð½Ð¾Ðµ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ðµ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¾ Ð½Ð° ÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð¿ÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð½Ð°Ð²ÑÐºÐ¾Ð² Ð¿ÑÐ¾ÑÐµÑÑÐ¸Ð¾Ð½Ð°Ð»ÑÐ½Ð¾-Ð¾ÑÐ¸ÐµÐ½ÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð¹ ÐºÐ¾Ð¼Ð¼ÑÐ½Ð¸ÐºÐ°ÑÐ¸Ð¸ Ð½Ð° ÑÑÑÑÐºÐ¾Ð¼ ÑÐ·ÑÐºÐµ Ñ Ð¸Ð½Ð¾ÑÑÑÐ°Ð½Ð½ÑÑ ÑÑÑÐ´ÐµÐ½ÑÐ¾Ð², Ð¾Ð±ÑÑÐ°ÑÑÐ¸ÑÑÑ
Ð² ÑÐ¾ÑÑÐ¸Ð¹ÑÐºÐ¸Ñ Ð²ÑÐ·Ð°Ñ. ÐÐ¾Ð´ÑÐ»ÑÐ½ÑÐ¹ Ð¿ÑÐ¸Ð½ÑÐ¸Ð¿ Ð¿Ð¾ÑÑÑÐ¾ÐµÐ½Ð¸Ñ ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸Ñ ÑÑÐµÐ±Ð½Ð¾Ð³Ð¾ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ð° Ð¿ÑÐµÐ´Ð¿Ð¾Ð»Ð°Ð³Ð°ÐµÑ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾Ðµ ÑÐ¾ÑÐµÑÐ°Ð½Ð¸Ðµ ÐºÐ°Ðº Ð°ÑÐ´Ð¸ÑÐ¾ÑÐ½Ð¾Ð¹, ÑÐ°Ðº Ð¸ Ð¿ÑÐ¾Ð´ÑÐºÑÐ¸Ð²Ð½Ð¾Ð¹ ÑÐ°Ð¼Ð¾ÑÑÐ¾ÑÑÐµÐ»ÑÐ½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ
ÑÑÑÐ´ÐµÐ½ÑÐ¾Ð². Ð¤ÑÐ½ÐºÑÐ¸Ð¾Ð½Ð°Ð»ÑÐ½Ð¾-ÐºÐ¾Ð¼Ð¼ÑÐ½Ð¸ÐºÐ°ÑÐ¸Ð²Ð½Ð°Ñ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð½Ð¾ÑÑÑ ÑÑÐµÐ±Ð½Ð¾Ð³Ð¾ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ñ Ð¾Ð±ÐµÑÐ¿ÐµÑÐ¸Ð²Ð°ÐµÑ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾Ðµ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ðµ ÑÐµÑÐµÐ²Ð¾Ð¹ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ Ð² ÑÐ¾ÑÐµÑÐ°Ð½Ð¸Ð¸ Ñ ÑÐ¸ÑÑÐ°ÑÐ¸Ð²Ð½Ð¾-Ð¿ÑÐ¾ÑÐµÑÑÐ¸Ð¾Ð½Ð°Ð»ÑÐ½ÑÐ¼
ÐºÐ¾Ð½ÑÐµÐºÑÑÐ¾Ð¼. Ð£ÑÐµÐ±Ð½ÑÐ¹ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð» Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð¾Ð²Ð°Ð½ Ð¿Ð¾ Ð¿ÑÐ¸Ð½ÑÐ¸Ð¿Ñ Ð½Ð°ÑÐ°ÑÑÐ°ÑÑÐµÐ¹ ÑÐ»Ð¾Ð¶Ð½Ð¾ÑÑÐ¸. Ð Ð°ÑÑÐ¸ÑÐµÐ½Ð¸Ðµ Ð»ÐµÐºÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð·Ð°Ð¿Ð°ÑÐ° Ð¿ÑÐ¾Ð¸ÑÑÐ¾Ð´Ð¸Ñ Ð² ÑÐ°Ð¼ÐºÐ°Ñ Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ Ð³ÑÐ°Ð¼Ð¼Ð°ÑÐ¸ÑÐµÑÐºÐ¸Ñ ÑÐµÐ¼.
Higher point MHV amplitudes in N=4 Supersymmetric Yang-Mills Theory
Creators: name: Vergu, C.
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We compute the even part of the two-loop seven-point planar MHV amplitude in N=4 supersymmetric Yang-Mills theory. We find that the even part is expressed in terms of conformal integrals with simple rational coefficients. We also compute the even part of two all-n cuts. An important feature of the result is that no hexagon (or higher polygon) loops appear among the integrals detected by the cuts we computed. We also present a "leg addition rule," which allows us to express some integral coefficients in the n+1-point MHV amplitude in terms of the integral coefficients of the n-point MHV amplitude.
D6.2 – Use case description and implementation Y3
Creators: name: Megliola, Maurizio
name: Plitsos, Stathis
name: Bernat Quesada Navidad
name: Munar, Antoni
name: McCreadie, Richard
name: Sidiropoulos, Anestis
name: Poulopoulos, Dimitris
Publisher: name: Zenodo
Year: 2021

description: BigDataStack delivers a complete high-performant stack of technologies addressing the needs of data operations and applications. The BigDataStack project was conceived as a data centric platform, integrating approaches for Data as a Service. Approaches for data cleaning, data layout and efficient storage, combined with seamless data analytics will be realised holistically across multiple data stores and locations. BigDataStack holistic solution incorporates approaches for data-focused application analysis and dimensioning, and process modelling towards increased performance, agility and efficiency. A toolkit allowing the specification of analytics tasks in a declarative way, their integration in the data path, as well as an adaptive visualization environment, realize BigDataStack’s vision of openness and extensibility.
title: ÐÑÐ±Ð¾Ñ Ð¾Ð¿ÑÐ¸Ð¼Ð°Ð»ÑÐ½ÑÑ ÑÐ¿ÑÐ°Ð²Ð»ÑÑÑÐ¸Ñ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ð¹ Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð°Ð²Ð°ÑÐ¸Ð¹Ð½Ð¾Ð¹ Ð°Ð²ÑÐ¾Ð¼Ð°ÑÐ¸ÐºÐ¸ Ð¿Ð¾ ÑÑÐ»Ð¾Ð²Ð¸ÑÐ¼ Ð¾Ð±ÐµÑÐ¿ÐµÑÐµÐ½Ð¸Ñ ÑÑÑÐ¾Ð¹ÑÐ¸Ð²Ð¾ÑÑÐ¸ ÑÐ¸ÑÑÐµÐ¼ ÑÐ»ÐµÐºÑÑÐ¾ÑÐ½Ð°Ð±Ð¶ÐµÐ½Ð¸Ñ
title: Ð¼Ð°Ð³Ð¸ÑÑÐµÑÑÐºÐ°Ñ Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ñ
titleType: Subtitle
Creators: name: ÐÐ°ÑÐ»ÐµÐ½ÑÐµÐ½ÐºÐ¾ , ÐÐ»ÑÑ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: Ð­Ð½ÐµÑÐ³ÐµÑÐ¸ÑÐµÑÐºÐ¸Ðµ ÑÐ¸ÑÑÐµÐ¼Ñ
ÐÑÑÐ¸ÑÐ»Ð¸ÑÐµÐ»ÑÐ½ÑÐµ Ð¼Ð°ÑÐ¸Ð½Ñ ÑÐ»ÐµÐºÑÑÐ¾Ð½Ð½ÑÐµ Ð¿ÐµÑÑÐ¾Ð½Ð°Ð»ÑÐ½ÑÐµ
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Ð¾Ð±Ð»Ð°ÑÑÑ ÑÑÑÐ¾Ð¹ÑÐ¸Ð²Ð¾ÑÑÐ¸

description: ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½ ÑÐ°ÑÑÐµÑ Ð¿ÑÐµÐ´ÐµÐ»ÑÐ½Ð¾Ð³Ð¾ ÑÐµÐ¶Ð¸Ð¼Ð° ÑÐ»ÐµÐºÑÑÐ¾ÑÐ½ÐµÑÐ³ÐµÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ Ð´Ð»Ñ ÑÐµÑÑÐ¾Ð²Ð¾Ð¹ ÑÑÐµÐ¼Ñ Ð² Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð°Ñ Matlab Ð¸ RastrWin. ÐÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð° Ð¾Ð±Ð»Ð°ÑÑÑ ÑÑÐ°ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÑÑÐ¾Ð¹ÑÐ¸Ð²Ð¾ÑÑÐ¸ ÑÐ¸ÑÑÐµÐ¼Ñ. Ð Ð°ÑÑÑÐ¸ÑÐ°Ð½ Ð¿Ð¾ÑÐ»ÐµÐ°Ð²Ð°ÑÐ¸Ð¹Ð½ÑÐ¹ ÑÐµÐ¶Ð¸Ð¼ Ð´Ð»Ñ ÑÐµÑÑÐ¾Ð²Ð¾Ð¹ ÑÑÐµÐ¼Ñ, Ð¿Ð¾ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐ°Ð¼ ÐºÐ¾ÑÐ¾ÑÐ¾Ð³Ð¾ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð° Ð¾Ð±Ð»Ð°ÑÑÑ ÑÑÑÐµÑÑÐ²Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐµÐ¶Ð¸Ð¼Ð°. ÐÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ñ Ð¾Ð¿ÑÐ¸Ð¼Ð°Ð»ÑÐ½ÑÐµ ÑÐ¿ÑÐ°Ð²Ð»ÑÑÑÐ¸Ðµ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð°Ð²Ð°ÑÐ¸Ð¹Ð½Ð¾Ð¹ Ð°Ð²ÑÐ¾Ð¼Ð°ÑÐ¸ÐºÐ¸ Ð´Ð»Ñ Ð²Ð²Ð¾Ð´Ð° ÑÐµÐ¶Ð¸Ð¼Ð° Ð² ÑÑÑ Ð¾Ð±Ð»Ð°ÑÑÑ Ð² ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð½Ð°ÑÑÑÐµÐ½Ð¸Ñ ÑÑÐ°ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÑÑÐ¾Ð¹ÑÐ¸Ð²Ð¾ÑÑÐ¸ ÑÐ¸ÑÑÐµÐ¼Ñ.
Comoving-frame radiative transfer in arbitrary velocity fields -- II. Large scale applications
Creators: name: Knop, S.
name: Hauschildt, P. H.
name: Baron, E.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: A solution of the radiative-transfer problem in arbitrary velocity fields introduced in a previous paper, has limitations in its applicability. For large-scale applications, the methods described also require large memory sets that are commonly not available to state-of-the-art computing hardware. In this work, we modify the algorithm to allow the computation of large-scale problems. We reduce the memory footprint via a domain decomposition. By introducing iterative Gauss-Seidel type solvers, we improve the speed of the overall computation. Because of the domain decomposition, the new algorithm requires the use of parallel-computing systems. The algorithm that we present permits large-scale solutions of radiative-transfer problems that include arbitrary wavelength couplings. In addition, we discover a quasi-analytic formal solution of the radiative transfer that significantly improves the overall computation speed. More importantly, this method ensures that our algorithm can be applied to multi-dimensional Lagrangian radiative-transfer calculations. In multi-dimensional atmospheres, velocity fields are in general chaotic ensuring that the inclusion of arbitrary wavelength couplings are mandatory.
title: Ð£Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ðµ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸ÑÐ¼Ð¸ ÐºÐ¾Ð¼Ð°Ð½Ð´Ñ Ð¿ÑÐ¾ÐµÐºÑÐ° Ð½Ð° Ð¿ÑÐ¸Ð¼ÐµÑÐµ Ð¿Ð¸Ð»Ð¾ÑÐ½Ð¾Ð³Ð¾ Ð¿ÑÐ¾ÐµÐºÑÐ° ÐÐ¢Ð Â«ÐÐÐ ÐÑÐµÐ¹Ð½ÑÐ¸ÑÐ½ÐµÑÂ»
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ¸Ð½ÑÑÐº, ÐÐ»ÐµÐºÑÐµÐ¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: Ð¼ÐµÑÐ¾Ð´ ÑÐ»Ð¾Ð¶Ð½ÑÑ ÑÐºÑÐ¿ÐµÑÑÐ¸Ð·
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description: ÐÑÐ¾Ð²ÐµÐ´ÑÐ½ Ð°Ð½Ð°Ð»Ð¸Ð· ÑÑÐµÐ±Ð¾Ð²Ð°Ð½Ð¸Ð¹ Ðº ÑÐ¸ÑÑÐµÐ¼Ðµ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸ÑÐ¼Ð¸ ÐºÐ¾Ð¼Ð°Ð½Ð´Ñ Ð¿ÑÐ¾ÐµÐºÑÐ°. Ð Ð°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ñ Ð¾ÑÐ½Ð¾Ð²Ð½ÑÐµ Ð¿ÑÐ¸Ð½ÑÐ¸Ð¿Ñ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¸ ÑÑÑÑÐºÑÑÑÐ½ÑÐµ Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸ Ð¿Ð¾Ð´Ð¾Ð±Ð½ÑÑ ÑÐ¸ÑÑÐµÐ¼. ÐÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ñ ÑÐ°ÐºÑÐ¾ÑÑ, Ð²Ð»Ð¸ÑÑÑÐ¸Ðµ Ð½Ð° ÑÑÑÑÐºÑÑÑÑ Ð¸ Ð¾ÑÐ´ÐµÐ»ÑÐ½ÑÐµ ÑÐ»ÐµÐ¼ÐµÐ½ÑÑ Ð¿Ð¾Ð´Ð¾Ð±Ð½ÑÑ ÑÐ¸ÑÑÐµÐ¼. ÐÑÑÐ²Ð»ÐµÐ½Ñ Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸ Ð¿ÑÐ¾ÐµÐºÑÐ° Â«ÐÐÐ ÐÑÐµÐ¹Ð½ÑÐ¸ÑÐ½ÐµÑÂ», Ð²Ð»Ð¸ÑÑÑÐ¸Ðµ Ð½Ð° ÑÑÐµÐ±Ð¾Ð²Ð°Ð½Ð¸Ñ Ðº ÑÐ°Ð·ÑÐ°Ð±Ð°ÑÑÐ²Ð°ÐµÐ¼Ð¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ðµ. ÐÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½ Ð¿ÑÐ¾ÐµÐºÑ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÑÑÑÐºÑÑÑÑ. Ð¡Ð¾Ð·Ð´Ð°Ð½ Ð¿Ð»Ð°Ð½ ÐºÐ¾Ð¼Ð¼ÑÐ½Ð¸ÐºÐ°ÑÐ¸Ð¹. ÐÑÐ¾Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ñ ÑÑÐµÐ±Ð¾Ð²Ð°Ð½Ð¸Ñ Ðº ÐÐ¡Ð¡Ð. Ð Ð°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ñ Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½ÑÐµ Ð¿Ð¾Ð´ÑÐ¾Ð´Ñ Ðº Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¸ ÐÐ¡Ð¡Ð. ÐÑÐ¾Ð¸Ð·Ð²ÐµÐ´ÑÐ½ Ð°Ð½Ð°Ð»Ð¸Ð· ÑÐ¿Ð¾ÑÐ¾Ð±Ð¾Ð² Ð¿ÑÐ¸Ð½ÑÑÐ¸Ñ ÑÐµÑÐµÐ½Ð¸Ð¹ Ð¸ Ð¸Ñ Ð¿ÑÐ¸Ð¼ÐµÐ½Ð¸Ð¼Ð¾ÑÑÐ¸ Ðº Ð¿ÑÐ¾Ð±Ð»ÐµÐ¼Ðµ Ð²ÑÐ±Ð¾ÑÐ° ÐÐ¡Ð¡Ð. ÐÑÐ¾Ð¸Ð·Ð²ÐµÐ´ÑÐ½ Ð²ÑÐ±Ð¾Ñ ÐÐ¡Ð¡Ð Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð´Ð²ÑÑ Ð¼ÐµÑÐ¾Ð´Ð¾Ð² Ð¿ÑÐ¸Ð½ÑÑÐ¸Ñ ÑÐµÑÐµÐ½Ð¸Ð¹. Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð° Ð¸Ð¼Ð¸ÑÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ Ð¼Ð¾Ð´ÐµÐ»Ñ ÐºÐ¾Ð¼Ð¼ÑÐ½Ð¸ÐºÐ°ÑÐ¸Ð¹ Ð² Ð¿ÑÐ¾ÐµÐºÑÐµ. ÐÑÐ¾Ð¸Ð·Ð²ÐµÐ´ÐµÐ½Ð¾ Ð¾Ð±Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¿ÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ð½Ð¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ. ÐÑÐ¸Ð¼ÐµÐ½ÑÐ½ Ð»Ð¾Ð³Ð¸ÐºÐ¾-ÑÑÑÑÐºÑÑÑÐ½ÑÐ¹ Ð¿Ð¾Ð´ÑÐ¾Ð´ Ð² ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ð¸ Ð¿ÑÐ¾ÐµÐºÑÐ¾Ð¼. ÐÑÐ¾Ð¸Ð·Ð²ÐµÐ´ÑÐ½ Ð°Ð½Ð°Ð»Ð¸Ð· Ð·Ð°Ð¸Ð½ÑÐµÑÐµÑÐ¾Ð²Ð°Ð½Ð½ÑÑ ÑÑÐ¾ÑÐ¾Ð½. ÐÑÑÐ²Ð»ÐµÐ½Ñ Ð¸ ÑÑÑÑÐºÑÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ñ Ð¿ÑÐ¾Ð±Ð»ÐµÐ¼Ñ Ð¸ ÑÐµÐ»Ð¸ Ð¿ÑÐ¾ÐµÐºÑÐ°. Ð¡Ð¾ÑÑÐ°Ð²Ð»ÐµÐ½Ð° Ð»Ð¾Ð³Ð¸ÐºÐ¾-ÑÑÑÑÐºÑÑÑÐ½Ð°Ñ Ð¼Ð°ÑÑÐ¸ÑÐ°. Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½ Ð¿Ð»Ð°Ð½ ÑÐµÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¿ÑÐ¾ÐµÐºÑÐ°. ÐÑÐ¾Ð¸Ð·Ð²ÐµÐ´ÑÐ½ ÑÐ°ÑÑÑÑ Ð·Ð°ÑÑÐ°Ñ Ð½Ð° ÑÐµÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ñ Ð¿ÑÐ¾ÐµÐºÑÐ°. ÐÑÐµÐ½ÐµÐ½Ð° ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ°Ñ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ Ð¿ÑÐ¾ÐµÐºÑÐ°. ÐÑÐ¾Ð²ÐµÐ´ÑÐ½ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑ Ð¼ÐµÑÐ¾Ð¿ÑÐ¸ÑÑÐ¸Ð¹ Ð¿Ð¾ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ ÑÐ¸ÑÐºÐ°Ð¼Ð¸ Ð¿ÑÐ¾ÐµÐºÑÐ°.
A long-term posttraumatic study in the rat median nerve crush injury model
Creators: name: Geuna, Stefano
name: Muratori, Luisa
name: Ronchi, Giulia
name: Raimondo, Stefania
name: Fornaro, Michele
name: Giacobini-Robecchi, Maria G.
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2011
Subjects: crush injury; nerve regeneration; median nerve; quantitative morphology; rat

description: The possibility that posttraumatic regeneration may eventually lead rat peripheral nerve fibers back to normal is still under debate. While it has been shown that, after a sufficiently long posttraumatic time, the number of regenerated rat peripheral nerve fibers can return to normal levels and the animal can regain normal pre-lesion function, no information regarding long-term changes in size parameters of regenerated nerve fibers is still available. To fill this gap, 24-week posttraumatic changes in myelinated axon and nerve fiber diameter, myelin thickness and g-ratio (axon diameter/fiber diameter), distal to a nerve crush (axonotmesis lesion) of the rat median nerve were assessed by stereology. Results showed that, while as expected fiber number returned to normal values at week-24, both axon and fiber diameter and myelin thickness were still significantly lower at week-24 in comparison to pre-lesion values. Finally, g-ratio, which persisted unmodified along the regeneration process, eventually resulted to be significantly reduced at week-24 in comparison to pre-lesion value. Based on these results, the hypothesis that regenerated rat peripheral nerve fibers are able to spontaneously return to normal, provided that a sufficiently long time recovery post-axonotmesis is allowed, is rejected.
description: Italian Journal of Anatomy and Embryology, Vol 116, No 1 (Supplement) 2011
Effects of GnRH agonist treatment on GnRH receptors in human prostate cancer cells: an atomic force microscopy study
Creators: name: Lama, Gina
name: Angelucci, Cristiana
name: Cupelli, Elisa
name: Sica, Gigliola
name: De Spirito, Marco
name: Papi, Massimiliano
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2011
Subjects: AFM; GnRH analogue; GnRH receptor; bound strength; receptor topografy

description: We previously demonstrated by Western blotting and immunocytochemistry that a GnRH agonist (leuprorelin acetate, LA) was able to induce a post-transcriptional increase in GnRH receptor (GnRH-R) expression at the plasma membrane of androgen-sensitive (LNCaP) and -insensitive (PC-3) prostate cancer (PCa) cells. In the present study, we used atomic force microscopy (AFM) to gain a deeper insight into the effects of LA on the behaviour of GnRH-R in highly invasive and poorly differentiated PC-3 cells. The use of this powerful, non-destructive technique allows to identify and study the biological features of the living cell surface, as ligand-receptor interactions. Here, we investigated for 6, 12, 18, 24 and 30 days, the effect of LA (10-11 and 10-6 M) in PC-3 cells on: i) amount of LA/GnRH-R binding events (i.e. GnRH-R quantification), ii) strength of the analogue-receptor binding, iii) receptor topography. Briefly, analogue molecules were immobilized onto conical AFM tips and the single agonist/receptor interactions were measured by force-distance cycles. In agreement with our previous results, the number of GnRH-R augmented during 30 days due to the effect of LA treatment. The increasing rate of GnRH-R was dose-dependent until the 24th day and reached the maximum (~70%) after 30 days of treatment with the highest dose of LA (10-6M). At least 2 different receptor bound strengths have been detected, probably due to the presence of two GnRH-R classes. The majority of the sites showed a relatively low bound strength (~37 piconewton). A LA/GnRH-R complex lifetime of ~ 9s and ~3.4 s for the higher and lower bound strength receptors, respectively, has been determined. Regarding GnRH-R topography, a homogeneous distribution of the binding events has been found on untreated and LA-treated PC-3 cell surfaces. The persistence of high receptor levels at the androgen-insensitive cell surface may warrant the maintenance of the response to the analogue in androgen-unresponsive PCa also, which might be useful in clinical practice. Moreover, the definition of parameters as ligand/receptor bond strength and lifetime could shed light on the poorly understood molecular basis of LA/GnRH-R interaction and might be used to address structural/chemical agonist optimizations.  Supported by Takeda Italia Farmaceutici SpA
description: Italian Journal of Anatomy and Embryology, Vol 116, No 1 (Supplement) 2011
Spectroscopy of 32Ne and the Island of Inversion
Creators: name: Doornenbal, P.
name: Scheit, H.
name: Aoi, N.
name: Takeuchi, S.
name: Li, K.
name: Takeshita, E.
name: Wang, H.
name: Baba, H.
name: Deguchi, S.
name: Fukuda, N.
name: Geissel, H.
name: Gernhäuser, R.
name: Gibelin, J.
name: Hachiuma, I.
name: Hara, Y.
name: Hinke, C.
name: Inabe, N.
name: Itahashi, K.
name: Itoh, S.
name: Kameda, D.
name: Kanno, S.
name: Kawada, Y.
name: Kobayashi, N.
name: Kondo, Y.
name: Krücken, R.
name: Kubo, T.
name: Kuboki, T.
name: Kusaka, K.
name: Lantz, M.
name: Michimasa, S.
name: Motobayashi, T.
name: Nakamura, T.
name: Nakao, T.
name: Namihira, K.
name: Nishimura, S.
name: Ohnishi, T.
name: Ohtake, M.
name: Orr, N. A.
name: Otsu, H.
name: Ozeki, K.
name: Satou, Y.
name: Shimoura, S.
name: Sumikama, T.
name: Takechi, M.
name: Takeda, H.
name: Tanaka, K. N.
name: Tanaka, K.
name: Togano, Y.
name: Winkler, M.
name: Yanagisawa, Y.
name: Yoneda, K.
name: Yoshida, A.
name: Yoshida, K.
name: Sakurai, H.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We report on the first spectroscopic study of the N=22 nucleus 32Ne at the newly completed RIKEN Radioactive Ion Beam Factory. A single gamma-ray line with an energy of 722(9) keV was observed in both inelastic scattering of a 226 MeV/u 32Ne beam on a Carbon target and proton removal from 33Na at 245 MeV/u. This transition is assigned to the de-excitation of the first J^pi = 2+ state in 32Ne to the 0+ ground state. Interpreted through comparison with state-of-the-art shell model calculations, the low excitation energy demonstrates that the Island of Inversion extends to at least N=22 for the Ne isotopes.
description: Accepted for publication in Phys. Rev. Lett. 11 pages, 3 figures
Additional file 1 of Treatment response and several patient-reported outcomes are early determinants of future self-efficacy in rheumatoid arthritis
Creators: name: Michaël, Doumen
name: Diederik, De Cock
name: Sofia, Pazmino
name: Delphine, Bertrand
name: Johan, Joly
name: René, Westhovens
name: Patrick, Verschueren
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Supplement 1. Standardised coefficients and bootstrapped CIs for direct and indirect effects of treatment response on self-efficacy.
title: ÐÐµÐ´Ð¸ÑÐ¸Ð½Ð° ÐºÐ°ÑÐ°ÑÑÑÐ¾Ñ
title: ÑÑÐµÐ±Ð½Ð¾Ðµ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ðµ Ð¿Ð¾ Ð°Ð½Ð³Ð»Ð¸Ð¹ÑÐºÐ¾Ð¼Ñ ÑÐ·ÑÐºÑ
titleType: Subtitle
title: Emergency medicine
Creators: name: Ð¯ÑÑÐ½Ð¸Ð½Ð°, ÐÐ»ÐµÐºÑÐ°Ð½Ð´ÑÐ°
name: ÐÐ¾Ð¿Ð¾Ð²Ð°, ÐÐ¸Ð½Ð°
Publisher: name: ÐÐ·Ð´-Ð²Ð¾ ÐÐ¾Ð»Ð¸ÑÐµÑÐ½. ÑÐ½-ÑÐ°
Year: 2009

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description: ÐÐµÑÐ°ÑÐ°ÐµÑÑÑ Ð¿Ð¾ ÑÐµÑÐµÐ½Ð¸Ñ ÑÐµÐ´Ð°ÐºÑÐ¸Ð¾Ð½Ð½Ð¾-Ð¸Ð·Ð´Ð°ÑÐµÐ»ÑÑÐºÐ¾Ð³Ð¾ ÑÐ¾Ð²ÐµÑÐ° Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¾Ð³Ð¾ Ð³Ð¾ÑÑÐ´Ð°ÑÑÑÐ²ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑÐ°.
Effect of HEMA on human gingival fibroblasts / Streptococcus mitis adhesion mediated by PKCα/ integrin β 1 intracellular signaling
Creators: name: Di Giacomo, Viviana
name: Pacella, Stephanie
name: Rapino, Monica
name: Di Giulio, Mara
name: Zara, Susi
name: Marconi, Guya Diletta
name: Cataldi, Amelia
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2013
Subjects: Eukaryotic/prokaryotic cells adhesion; HEMA; PKCα;, integrin β 1

description: Human gingival fibroblasts are the major constituents of periodontal connective tissue, exposed to leachable form of dental restorative materials, such as HEMA, undergoing biological effects as reduction of proliferation, occurrence of apoptosis and inflammation. Integrin β 1 is a protein involved not only in the regulation of cell migration, proliferation , survival, apoptosis and differentiation but also in the adhesion eukaryotic/prokaryotic cells (Engels-Deutsch et al.,2011). Since previous reported evidences suggest PKC α as the main PKC expressed and activated by HEMA in human gingival fibroblasts (Cataldi et al.,2012) the molecular mechanisms mediated by PKCα through integrin β 1 driving the response to HEMA of HGF/Streptococcus mitis co-culture in terms of proliferation, adhesion and apoptosis have been investigated. HEMA treatment increases the adhesion between S. mitis and HGF, mediated by PKCα / integrin β 1 signalling system, improved by the presence of saliva, and reduces the expression of MMP2, involved in the remodelling of the extracellular matrix, which seems to control apoptosis occurrence, mainly reduced when saliva is added to the co- culture. These results, shedding more light on the biological and molecular events occurring in vitro in a co-culture model, which mimics the environment of the oral cavity, upon HEMA treatment, allow to confirm the key role played by oral bacteria and saliva to prevent inflammatory and toxic processes which can occur in vivo in human gingival fibroblasts upon the release of dental material monomers.
description: Italian Journal of Anatomy and Embryology, Vol 117, No 2 (Supplement) 2012