title: ÐÐ¸Ð¿ÐµÑÑÐºÑÐ¿ÑÐµÑÑÐ¸Ñ Bcl-2-Ð±ÐµÐ»ÐºÐ° Ð¿ÑÐµÐ¿ÑÑÑÑÐ²ÑÐµÑ Ð½Ð°ÐºÐ¾Ð¿Ð»ÐµÐ½Ð¸Ñ Ð°Ð¼Ð¸Ð»Ð¾Ð¸Ð´Ð½ÑÑ Ð±Ð»ÑÑÐµÐº Ð² Ð³Ð¾Ð»Ð¾Ð²Ð½Ð¾Ð¼ Ð¼Ð¾Ð·Ð³Ðµ Ð¼ÑÑÐµÐ¹ Ñ Ð¼Ð¾Ð´ÐµÐ»ÑÑ Ð±Ð¾Ð»ÐµÐ·Ð½Ð¸ ÐÐ»ÑÑÐ³ÐµÐ¹Ð¼ÐµÑÐ°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: The overexpression of Bcl-2 protein prevents the accumulation of amyloid plaques in the brain of Alzheimers disease model mice
Creators: name: ÐÐ¾Ð»Ð¾Ð·Ð¾Ð²Ð°, ÐÐ°ÑÐ¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2023
Subjects: Ð±Ð¾Ð»ÐµÐ·Ð½Ñ ÐÐ»ÑÑÐ³ÐµÐ¹Ð¼ÐµÑÐ°
Ð¼ÑÑÐ¸Ð½Ð°Ñ Ð¼Ð¾Ð´ÐµÐ»Ñ 5xFAD
Ð±ÐµÐ»Ð¾Ðº Bcl-2
Ð°Ð¼Ð¸Ð»Ð¾Ð¸Ð´Ð½ÑÐµ Ð±Ð»ÑÑÐºÐ¸
Ð¿ÑÐ¾ÑÑÑÐ°Ð½ÑÑÐ²ÐµÐ½Ð½Ð°Ñ Ð¿Ð°Ð¼ÑÑÑ
Alzheimers disease
5xFAD mouse model
Bcl-2 protein
amyloid plaques
spatial memory

description: Ð Ð´Ð¾Ð¿Ð¾Ð»Ð½ÐµÐ½Ð¸Ðµ Ðº Ð¾ÑÐ½Ð¾Ð²Ð½Ð¾Ð¹ Ð°Ð½ÑÐ¸Ð°Ð¿Ð¾Ð¿ÑÐ¾ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÑÐ½ÐºÑÐ¸Ð¸, Ð±ÐµÐ»Ð¾Ðº Bcl-2 ÑÐµÐ³ÑÐ»Ð¸ÑÑÐµÑ ÐºÐ°Ð»ÑÑÐ¸ÐµÐ²ÑÐ¹ Ð¼ÐµÑÐ°Ð±Ð¾Ð»Ð¸Ð·Ð¼, Ð½Ð°ÑÑÑÐµÐ½Ð¸Ñ ÐºÐ¾ÑÐ¾ÑÐ¾Ð³Ð¾ Ð½Ð°Ð±Ð»ÑÐ´Ð°ÑÑÑÑ Ð² Ð½ÐµÐ¹ÑÐ¾Ð½Ð°Ñ Ð¿ÑÐ¸ ÑÐµÑÐµÐ½Ð¸Ð¸ Ð±Ð¾Ð»ÐµÐ·Ð½Ð¸ ÐÐ»ÑÑÐ³ÐµÐ¹Ð¼ÐµÑÐ°. Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð¿ÑÐ¾Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½ ÑÑÑÐµÐºÑ Ð³Ð¸Ð¿ÐµÑÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð±ÐµÐ»ÐºÐ° Bcl-2 Ð² Ð³Ð¸Ð¿Ð¿Ð¾ÐºÐ°Ð¼Ð¿Ð°Ð»ÑÐ½ÑÑ Ð½ÐµÐ¹ÑÐ¾Ð½Ð°Ñ Ð½Ð° Ð½Ð°ÐºÐ¾Ð¿Ð»ÐµÐ½Ð¸Ðµ Ð°Ð¼Ð¸Ð»Ð¾Ð¸Ð´Ð½ÑÑ Ð±Ð»ÑÑÐµÐº Ð² Ð³Ð¾Ð»Ð¾Ð²Ð½Ð¾Ð¼ Ð¼Ð¾Ð·Ð³Ðµ Ð¸ Ð¿ÑÐ¾ÑÑÑÐ°Ð½ÑÑÐ²ÐµÐ½Ð½ÑÑ Ð¿Ð°Ð¼ÑÑÑ Ð² ÑÐµÑÑÐµ Â«ÐÐ¾Ð´Ð½ÑÐ¹ Ð»Ð°Ð±Ð¸ÑÐ¸Ð½Ñ ÐÐ¾ÑÑÐ¸ÑÐ°Â» Ñ Ð¼ÑÑÐµÐ¹ Ð»Ð¸Ð½Ð¸Ð¸ 5xFAD, Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÑÑÑÐµÐ¹ Ð±Ð¾Ð»ÐµÐ·Ð½Ñ ÐÐ»ÑÑÐ³ÐµÐ¹Ð¼ÐµÑÐ°. Ð ÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐ²Ð¸Ð´ÐµÑÐµÐ»ÑÑÑÐ²ÑÑÑ Ð¾ ÑÐ¾Ð¼, ÑÑÐ¾ Bcl-2-Ð¾Ð¿Ð¾ÑÑÐµÐ´Ð¾Ð²Ð°Ð½Ð½Ð¾Ðµ Ð¸Ð½Ð³Ð¸Ð±Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ RyR ÐºÐ°Ð½Ð°Ð»Ð¾Ð² Ð²ÑÑÐ¾Ð´Ð° ÐºÐ°Ð»ÑÑÐ¸Ñ Ð¸Ð· ÑÐ½Ð´Ð¾Ð¿Ð»Ð°Ð·Ð¼Ð°ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐµÑÐ¸ÐºÑÐ»ÑÐ¼Ð° Ð¿ÑÐµÐ¿ÑÑÑÑÐ²ÑÐµÑ Ð½Ð°ÐºÐ¾Ð¿Ð»ÐµÐ½Ð¸Ñ Ð°Ð¼Ð¸Ð»Ð¾Ð¸Ð´Ð° Ð¸ ÑÐ»ÑÑÑÐ°ÐµÑ Ð¿ÑÐ¾ÑÑÑÐ°Ð½ÑÑÐ²ÐµÐ½Ð½ÑÑ Ð¿Ð°Ð¼ÑÑÑ Ð² 5xFAD Ð¼ÑÑÐ¸Ð½Ð¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð±Ð¾Ð»ÐµÐ·Ð½Ð¸ ÐÐ»ÑÑÐ³ÐµÐ¹Ð¼ÐµÑÐ°. Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ð¾ Ð¿Ð¾Ð»Ð¾Ð¶Ð¸ÑÐµÐ»ÑÐ½Ð¾Ðµ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Bcl-2-Ð±ÐµÐ»ÐºÐ° Ð½Ð° Ð¿ÑÐµÐ´Ð¾ÑÐ²ÑÐ°ÑÐµÐ½Ð¸Ðµ Ð½Ð°ÐºÐ¾Ð¿Ð»ÐµÐ½Ð¸Ñ Ð°Ð¼Ð¸Ð»Ð¾Ð¸Ð´Ð½ÑÑ Ð±Ð»ÑÑÐµÐº Ð² Ð³Ð¸Ð¿Ð¿Ð¾ÐºÐ°Ð¼Ð¿Ðµ Ð¸Â  ÐºÐ¾Ð³Ð½Ð¸ÑÐ¸Ð²Ð½ÑÐµ ÑÑÐ½ÐºÑÐ¸Ð¸ Ð¼ÑÑÐµÐ¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸ 5xFAD, Ð¿Ð¾ÑÑÐ¾Ð¼Ñ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð½ÑÐ¹ Ð¼ÐµÑÐ°Ð½Ð¸Ð·Ð¼ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Bcl-2-Ð±ÐµÐ»ÐºÐ° ÑÐ²Ð»ÑÐµÑÑÑ Ð¿ÐµÑÑÐ¿ÐµÐºÑÐ¸Ð²Ð½ÑÐ¼ Ñ ÑÐ¾ÑÐºÐ¸ Ð·ÑÐµÐ½Ð¸Ñ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ¸ Ð»ÐµÐºÐ°ÑÑÑÐ²ÐµÐ½Ð½Ð¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸ Ð´Ð»Ñ Ð»ÐµÑÐµÐ½Ð¸Ñ Ð±Ð¾Ð»ÐµÐ·Ð½Ð¸ ÐÐ»ÑÑÐ³ÐµÐ¹Ð¼ÐµÑÐ°.
description: In addition to the main anti-apoptotic function, Bcl-2 protein regulates the intracellular calcium metabolism. In this paper, the effect of Bcl-2 protein overexpression in hippocampal neurons on the accumulation of amyloid plaques in the brain and spatial memory in the Morris water maze test of 5xFAD Alzheimers disease model mice was analyzed. The results of the study indicate that the Bcl-2-mediated inhibition of RyR channels of calcium release from the endoplasmic reticulum prevents amyloid accumulation and improves spatial memory in the 5xFAD mouse model of Alzheimers disease. This paper presents the positive effect of Bcl-2 protein on preventing the accumulation of amyloid plaques in the hippocampus and on the cognitive functions of 5xFAD mice, therefore, the studied mechanism of Bcl-2 protein action is promising in terms of developing a drug therapy for the treatment of Alzheimers disease.