cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Short-term nutrition and growth indicators in 6-month- to 6-year-old children are improved following implementation of a multidisciplinary community-based programme in a chronic conflict setting
Creators: Simonyan, Hambardzum
Sargsyan, Aelita
Allahverdi Balalian, Arin
Davtyan, Karapet
Gupte, Himanshu A
Publisher: name: Columbia University
Year: 2019
Subjects: Growth
Malnutrition in children
Malnutrition
Human evolution
Interdisciplinary research

description: Objective: We investigated short- and long-term indicators of malnutrition and diet before and after the community-based ‘Breaking the Cycle of Poverty’ multidisciplinary intervention. Design: A historically and geographically controlled study using data collected in 2013 and 2016. We compared the prevalence of short-term indicators (anaemia, breast-feeding duration and minimum dietary diversity) and long-term indicators (stunting and wasting) in exposed communities at two time points. We then compared these factors in geographic areas exposed or not exposed to intervention. We conducted logistic regression analyses on the 2016 sample to measure associations between living in intervention communities and child growth indicators. Setting: Berd region, a chronic conflict zone near the north-eastern border of Armenia and Azerbaijan. Participants: Children aged 6 months to 6 years. Results: Analyses included data from 2013 comprising 382 children, and data from 2016 comprising 348 children living in communities where the programme was implemented, and 635 children from unexposed communities. Anaemia prevalence in exposed communities was significantly lower in 2016 v. 2013 (10·9 v. 19·1 %, P < 0·01). Minimum dietary diversity (79·0 v. 68·1 %, P < 0·001) and breast-feeding duration (13·0 v. 11·5 months, P < 0·002) were significantly improved in exposed communities. Prevalences of stunting (11·5 v. 10·2 %, P = 0·57) and wasting (4·8 v. 2·0 %, P = 0·07) were not significantly different. Odds of anaemia were significantly lower (OR = 0·24, 95 % CI 0·16, 0·36) in intervention communities. Conclusions: Exposure to a community-based multidisciplinary intervention reduced the rate of anaemia and improved dietary indicators.
Roccellatol, a new β-orcinol based metabolite from the lichen Roccella montagnei
Creators: name: Uppuluri V. Mallavadhani
name: Akella V. S. Sudhakar
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Plant Biology

description: Roccellatol, a new (2′R,3′S)-erythrityl-2,6-dihydroxy-4-methylbenzoate was isolated along with nine known compounds from the fruticose lichen, Roccella montagnei Bel. em. D.D. Awasthi. The structure of the new compound was elucidated by detailed spectroscopic analysis (1H, 13C, DEPT and HRMS). The present isolation of roccellatol (10) assumes significance as the esters of p-orcellinic acid are rare in lichens. Interestingly, among the known compounds, (+)-montagnetol (9) was now isolated in very large quantity (4.66%).
Microplastic pollution: Phytotoxicity, environmental risks, and phytoremediation strategies
Creators: name: Li, Xiaona
name: Wang, Xiaowei
name: Ren, Chunting
name: Palansooriya, Kumuduni Niroshika
name: Wang, Zhenyu
name: Chang, Scott X.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Plant Biology

description: Microplastics (MPs) are emerging contaminants that adversely affect environmental health. In this review, we discuss the uptake of MPs by plants via endocytosis and crack-entry pathways in the roots and stomata of leaves; the translocation of MPs via xylem and phloem; and the toxicity of MPs to diverse plant species through oxidative stress, inhibition of photosynthesis, cytotoxicity, and genotoxicity. It’s difficult to assess the health risks of MPs because they directly cause toxicity and also change soil properties and the bioavailability of coexisting pollutants, such as plastic additives, in the plant rhizosphere, and bioaccumulate along the food chain. Moreover, compared to the uptake behavior and phytotoxicity effects of MPs in laboratory and hydroponic studies, MPs of various shapes, sizes, and types are likely to cause different effects on plants in complex natural environments. This review proposes potential phytoremediation strategies, including phytoextraction, immobilization, and rhizoremediation, for MP pollutants and provides guidelines for the bioremediation of MP-contaminated environments to enhance environmental sustainability. In the phytoremediation of MP pollution, the selection and disposal of plants used for phytoremediation and the optimization of functional microbes in the rhizosphere remain challenging. Future studies should address knowledge gaps in (i) methods for determining environmentally-relevant concentrations of MPs, (ii) the assessment of the ecological and human health risks of MPs in the natural environment, and (iii) the development of effective strategies for the phytoremediation of MP pollution.
Cancer stem cells CD133 inhibition and cytotoxicity of certain 3-phenylthiazolo[3,2-a]benzimidazoles: design, direct synthesis, crystal study and in vitro biological evaluation
Creators: name: Al-Ansary, Ghada H.
name: Wagdy M. Eldehna
name: Ghabbour, Hazem A.
name: Al-Rashood, Sara T. A.
name: Al-Rashood, Khalid A.
name: Radwa A. Eladwy
name: Al-Dhfyan, Abdullah
name: Kabil, Maha M.
name: Abdel-Aziz, Hatem A.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer

description: Cancer stem cells (CSCs) have been objects of intensive study since their identification in 1994. Adopting a structural rigidification approach, a novel series of 3-phenylthiazolo[3,2-a]benzimidazoles 4a–d was designed and synthesised, in an attempt to develop potent anticancer agent that can target the bulk of tumour cells and CSCs. The anti-proliferative activity of the synthesised compounds was evaluated against two cell lines, namely; colon cancer HT-29 and triple negative breast cancer MDA-MB-468 cell lines. Also, their inhibitory activity against the cell surface expression of CD133 was examined. In particular, compound 4b emerged as a promising hit molecule as it manifested good antineoplastic potency against both tested cell lines (IC50 = 9 and 12 μM, respectively), beside its ability to inhibit the cell surface expression of CD133 by 50% suggesting a promising potential of effectively controlling the tumour by eradicating the tumour bulk and inhibiting the proliferation of the CSCs. Moreover, compounds 4a and 4c showed moderate activity against HT-29 (IC50 = 21 and 29 μM, respectively) and MDA-MB-468 (IC50 = 23 and 24 μM, respectively) cell lines, while they inhibited the CD133 expression by 14% and 48%, respectively. Finally, a single crystal X-ray diffraction was recorded for compound 4d.
South Asian 	summer monsoon response to aerosol-forced sea surface temperatures
Creators: Li, Xiaoqiong
Ting, Mingfang
You, Yujia
Lee, Dong Eun
Westervelt, Daniel M.
Ming, Yi
Publisher: name: Columbia University
Year: 2020
Subjects: Monsoons
Rain and rainfall

description: Climate models suggest that anthropogenic aerosol‐induced drying dominates the historicalrainfall changes over the heavily populated South Asian monsoon region. The regional response dependson both the aerosol fast radiative effect and the slow process through sea surface temperature (SST)cooling. Two atmospheric general circulation models, NCAR‐CAM5 and GFDL‐AM3, are used to investigatethe monsoon response to prescribed aerosol‐forced SSTs. The total SST is separated into uniform cooling anda spatially varying component characterized by interhemispheric asymmetry. The monsoon rainfall ispredominantly controlled by the nonuniform SSTs, in the local Indian Ocean, South, and East China Seas(IO‐CSs). The reduced meridional SST gradient in the IO‐ CSs leads to weakened monsoon circulation,which drives a north‐south dipole rainfall change. The latitudinal location of the dipole shows modeldependence due to differences in local SSTs and their meridional gradient, which determines the latitudinallocation of the meridional overturning circulation responses.
Additional file 2 of The composite risk index based on frailty predicts postoperative complications in older patients recovering from elective digestive tract surgery: a retrospective cohort study
Creators: name: Li, Chun-Qing
name: Zhang, Chen
name: Yu, Fan
name: Li, Xue-Ying
name: Wang, Dong-Xin
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Marine Biology
subject: Mental Health
subject: Hematology

description: Additional file 2: Supplementary Table 2 Surgical procedures stratified according to Operative Stress Score.
BROADCAST MEDIA AS A CATALYST FOR LANGUAGE AND CULTURAL IDENTITY IN RIVERS STATE, NIGERIA
Creators: name: Ire, Ebele, Stella (PhD)
Publisher: name: top journals
Year: 2025
Subjects: Broadcast Media, Catalyst, Language and Cultural Identity, Rivers State, Nigeria

description: This study ascertained the broadcast media as a catalyst for language and cultural identity in Rivers State, Nigeria. Cultural transmission theory was anchored in this study. This study adopted the qualitative research approach using the library research method. The population of the study comprised all published and unpublished works relevant to media and cultural studies in Nigeria, estimated at over 2,000 accessible academic sources within university libraries, media archives, and online scholarly databases. From this population, a purposive sample size of 150 key texts was selected based on their relevance, recency, credibility and thematic alignment with the study's objectives. The sampling technique employed was purposive sampling and data collection involved systematically reviewing and synthesizing these sources, focusing on thematic content such as language representation, cultural promotion, and the roles of local media in Rivers State. Data analysis was conducted through content analysis, which enabled the identification of recurring themes, patterns and conceptual linkages across the reviewed literature. The study found that broadcast media in Rivers State incorporates indigenous languages and cultural content to a moderate extent, with certain ethnic groups, such as the Ikwerre, Kalabari, and Ogoni, being better represented than others due to linguistic diversity and the broader popularity of their languages in the media. However, the incorporation of these languages remains limited by market demands and resource constraints within local broadcasting stations. The study concluded that while broadcast media in Rivers State incorporates indigenous languages to a moderate extent, the diversity of languages spoken in the region requires further efforts to ensure equitable representation of all ethnic groups. Addressing the limitations in resources and market demands could. The study recommended that broadcast media in Rivers State should increase the representation of all indigenous languages to ensure equitable cultural representation and foster inclusivity across the region’s diverse ethnic groups
Enhancing Adversarial Transferability in Object Detection with Bidirectional Feature Distortion
Publisher: name: IEEE Signal Processing Society
Year: 2024

description: Previous works have shown that perturbing internal-layer features can significantly enhance the transferability of black-box attacks in classifiers. However, these methods have not achieved satisfactory performance when applied to detectors due to the inherent differences in features between detectors and classifiers. In this paper, we introduce a concise and practical untargeted adversarial attack in a label-free manner, which leverages only the feature extracted from the backbone model. By implicitly suppressing the critical feature elements for detection while enhancing the candidate object-relevant elements corresponding to possible detection boxes, we conduct a Bidirectional Feature Distortion Attack (BFDA). Experimental results show that BFDA achieves state-of-the-art black-box transferability on various detector architectures.
Data Management Plan template, Waipapa Taumata Rau, University of Auckland
Creators: name: Wharton, Yvette
name: Esling, Simon
name: Shadfar, Shamim
name: Hopkins, Sarah
name: Armstrong, Laura
Publisher: name: The University of Auckland
Year: 2024
Subjects: classificationCode: 460599
subject: Data management and data science not elsewhere classified

description: The 2024 version of the University of Auckland's Data Management Plan template has been co-designed with researchers as part of the University's RDM Programme initiatives: machine-actionable Data Management Planning. This template replaces the previously published template and guide, see links in record.
Subnanomolar indazole-5-carboxamide inhibitors of monoamine oxidase B (MAO-B) continued: indications of iron binding, experimental evidence for optimised solubility and brain penetration
Creators: name: Tzvetkov, Nikolay T.
name: Antonov, Liudmil
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Neuroscience
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Pharmacological and physicochemical studies of N-unsubstituted indazole-5-carboxamides (subclass I) and their structurally optimised N1-methylated analogues (subclass II), initially developed as drug and radioligand candidates for the treatment and diagnosis of Parkinson’s disease (PD), are presented. The compounds are highly brain permeable, selective, reversible, and competitive monoamine oxidase B (MAO-B) inhibitors with improved water-solubility and subnanomolar potency (pIC50 >8.8). Using a well-validated, combined X-ray/modelling technology platform, we performed a semi-quantitative analysis of the binding modes of all compounds and investigated the role of the indazole N1 position for their MAO-B inhibitory activity. Moreover, compounds NTZ-1006, 1032, and 1441 were investigated for their ability to bind Fe2+ and Fe3+ ions using UV-visible spectroscopy.
Linear-Time Temporal Logic with Team Semantics: Expressivity and Complexity
Creators: name: Virtema, Jonni
name: Hofmann, Jana
name: Finkbeiner, Bernd
name: Kontinen, Juha
name: Yang, Fan
Publisher: name: CISPA
Year: 2023

description: We study the expressivity and complexity of model checking of linear temporal logic with team semantics (TeamLTL). TeamLTL, despite being a purely modal logic, is capable of defining hyper- properties, i.e., properties which relate multiple execution traces. TeamLTL has been introduced quite recently and only few results are known regarding its expressivity and its model checking problem. We relate the expressivity of TeamLTL to logics for hyperproperties obtained by extending LTL with trace and propositional quantifiers (HyperLTL and HyperQPTL). By doing so, we obtain a number of model checking results for TeamLTL and identify its undecidability frontier. In particular, we show decidability of model checking of the so-called left-flat fragment of any downward closed TeamLTL-extension. Moreover, we establish that the model checking problem of TeamLTL with Boolean disjunction and inclusion atoms is undecidable.
Flexible versus robust lot-scheduling subject to random production yield and deterministic dynamic demand
Creators: name: Helber, Stefan
name: Inderfurth, Karl
name: Sahling, Florian
name: Schimmelpfeng, Katja
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: We consider the problem of scheduling production lots for multiple products competing for a common production resource that processes the product units serially. The demand for each product and period is assumed to be known with certainty, but the yield per production lot is random as the production process can reach an out-of-control state while processing each single product unit of a lot. A service-level constraint is used to limit the backlog in the presence of this yield uncertainty. We address the question of how to determine static production lots and how to schedule these lots over the discrete periods of a finite planning horizon. The scheduling problem is characterized by a trade-off between the cost of holding inventory and the cost of overtime, whereas the production output is uncertain. For this purpose, we develop a rigid and robust planning approach and two flexible heuristic scheduling approaches. In an extensive numerical study, we compare the different approaches to assess the cost of operating according to a robust plan as opposed to a flexible policy.
Deconvolution of transcriptomic data shows biologically and clinically relevant signals in pancreatic tumors
Creators: name: Kakoichankava, Aliaksandra
name: Bauer, Andrea
name: Siatkouski, Aliaksandr
name: Arlouski, Yuri
name: Zhyltsou, Ivan
name: Dedyulya, Konstantin
name: Dittmar, Gunnar
name: Hoheisel, Jorg
name: Nazarov, Petr V.
Publisher: name: F1000 Research Limited
Year: 2020

description: Pancreatic cancer stays a significant challenge to the oncology. The early stages of the disease are asymptomatic. This limits diagnosis and treatment of the neoplastic process and thus lead to a reduced survival prognosis. Here we proposed using deconvolution based on consensus independent component analysis (ICA), implemented in the recent package consICA, for identification pathophysiological processes affecting survival of patients with pancreatic cancer and survival prediction. Components identified by ICA were annotated by biological functions and linked to survival using Cox regression as is described in. Unlike in melanoma, no direct link was found between immune response and survival, perhaps due to an antinomic effect. ICA was able to detect transcriptional signals specific to stroma and tumors. Abundance of normal pancreas tissue as well as immune cells was detected in an unsupervised manner and correlated to an independent observation of an immuno-histopahthologist. For Bailey dataset such correlation was observed with in silico predictions. We also combined two independent datasets obtained form DKFZ (training) and Bailey (testing) and analysed the joint data. Survival of the patients in the test cohort was performed with a high level of significance (p-value 8e-4).
ФИЗИЧЕСКAЯ КУЛЬТУРA В ПЕДAГOГИЧЕСКOЙ СИСТЕМЕ OБРAЗOВAТЕЛЬНЫХ УЧРЕЖДЕНИЙ
Creators: name: Таирова, Мапрат
name: Тураев, Олимбек
Publisher: name: Zenodo
Year: 2024

description: Сoдержaние учебнoгo предметa «Физическaя культурa» в педaгoгическoй системе oбрaзoвaтельных учреждений является oдним из ключевых кoмпoнентoв фoрмирoвaния здoрoвoгo и физически рaзвитoгo пoкoления. Физическaя культурa в oбрaзoвaтельнoй системе имеет свoю специфику, oнa предстaвляет сoбoй сoвoкупнoсть знaний, умений и нaвыкoв, нaпрaвленных нa рaзвитие физических кaчеств и oхрaну их здoрoвья.
Two new eremophilenolides from the roots of Ligulariopsis shichuana and their anti-phytopathogenic fungal and antifeedant activities
Creators: name: Wu, Haibo
name: Liu, Tingting
name: Lian, Yuxuan
name: Wang, Wenshu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: Two new eremophilenolides, ligushicins A (1) and B (2), and two known compounds including β-sitosterol and ursolic acid were isolated from Ligulariopsis shichuana. The structures of new compounds were established on the basis of 1D and 2D NMR data and HRESIMS data interpretation. The absolute configuration of new compounds was assigned by ECD spectroscopy, and that of ligushicins A (1) was confirmed by X-ray diffraction analysis. The antifungal and antifeedant activities of new compounds were evaluated against four plant pathogenic fungi and third-instar larvae of Plutella xylostella, respectively. Ligushicins A (1) and B (2) exhibited potent antifungal activity against Botrytis cinerea and Fusarium oxysporum with minimum inhibitory concentration (MIC) values ranging from 50 to 100 mg/L, while they also exhibited weak antifeedant activities.
First total synthesis of parvistone C and its C8-epimer
Creators: name: Jala, Ranjith
name: Nomula, Rajesh
name: Palakodety Radha Krishna
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Marine Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Diastereoselective first total synthesis of parvistone C 1 and C8-epimer 1a are described. The key features of our synthesis include Sharpless asymmetric dihydroxylation, stereoselective aryl Grignard reactions, Still–Gennari olefination, and intramolecular cyclization.
Structural Violence Against Indigenous Peoples: Russian Federation
Creators: Gosart, Ulia
Publisher: name: Columbia University
Year: 2017
Subjects: Human rights
Indigenous peoples
Indigenous peoples--Legal status, laws, etc.
Indigenous peoples--Politics and government
Indigenous peoples--Social conditions

description: This work emphasizes that structural violence toward Indigenous Peoples, as enacted through the workings of contemporary institutions of governance of the Russian state, recreates the oppression characteristic of the Soviet era. This study reveals continuity between Soviet treatment and political opportunities of the “small Peoples of the North,” as the official terminology goes—the original 26 communities who would gain Indigenous status with the establishment of the Russian state—and the legal and political institutions defining indigeneity in contemporary Russia. Further, it argues that the question of Indigenous rights stemmed from and remains a part of nationality policies, a statewide set of measures focused on the political rights of the non-Russian groups within the multicultural federal system of Soviet and post- Soviet Russia. These policies institutionalized the notion of inferiority of (now Indigenous) communities as dependent on the guidance and financial assistance of the state. The notion of inferiority shaped the consciousness of Soviet and post-Soviet authorities who continue to administer these Indigenous communities as populations dependent upon the state. And yet, the opportunities to participate in the state system of administration since the Soviet times shaped Indigenous politics in post-Soviet Russia; and the fact that Indigenous activists are able to envision their communities as “Indigenous Peoples,” or communities with a right to self-determined existence, signifies a step forward, despite increased oppression against non-Russian minorities today in response to the current use of nationality policies as a means toward centralization of the state. This essay develops these claims in three interrelated essays, aimed at disseminating findings from Russian and western scholarship, and at stimulating more research in the areas examined. The first essay, “Legal and Institutional Framework Concerning Indigenous Rights,” reviews legal developments in the area of Indigenous rights and draws primarily from legal scholarship. The second essay, “Means of Resistance to Structural Violence: Indigenous Politics,” theorizes means of Indigenous advocacy, drawing upon studies of Soviet and post-Soviet political institutions supporting rights of Indigenous and other cultural minorities. It also investigates the history of post- Soviet Indigenous mobilizations. The final essay, “Consequences of Structural Violence,” examines the effects of structural violence and draws from the studies of Indigenous demographics and socioeconomic conditions of Indigenous populations, and the recent 2010 census data. The essay advocates for the widening of political opportunities for Indigenous Peoples at the regional and local levels of the contemporary Russian state.
Three-moment approximation for the mean queue time of a GI/G/1 queue
Creators: name: Wu, Kan
name: Srivathsan, Sandeep
name: Yichi Shen
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 111714 Mental Health
subject: FOS: Health sciences

description: The approximation of a GI/G/1 queue plays a key role in the performance evaluation of queueing systems. To improve the conventional two-moment approximations, we propose a three-moment approximation for the mean queue time of a GI/G/1 queue based on the exact results of the H2/M/1 queue. The model is validated over a wide range of numerical experiments. Based on paired t-tests, our three-moment approximation outperforms the two-moment ones when the inter-arrival time variability is greater than one.
Ectopic expression of the transcription factor CUC2 restricts growth by cell cycle inhibition in Arabidopsis leaves
Creators: name: Li, Xiaoyu
name: Zheng, Yucai
name: Xing, Qian
name: Ardiansyah, Rhomi
name: Zhou, Hui
name: Ali, Shahid
name: Jing, Tingting
name: Tian, Jingjing
name: Song, Xing Shun
name: Li, Yuhua
name: Müller-Xing, Ralf
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology
subject: Computational Biology

description: Plant leaf margins produce small outgrowths or teeth causing serration in a regular arrangement, which is specified by auxin maxima. In Arabidopsis, the spatiotemporal pattern of auxin dependents on both, the transcription factor CUC2 and the signal peptide EPFL2, a ligand of the growth-promoting receptor kinase ERECTA (ER). Ectopic expression of CUC2 can have contrary effects on leaf growth. Ubiquitous expressed CUC2 suppresses growth in the whole leaf, whereas cuc2-1D mutants have enlarged leaves, through ER-dependent cell proliferation in the teeth. Here we investigated the growth dynamics of cuc2-1D leaves and the growth restricting the function of CUC2 using the ubiquitous inducible CUC2-GR transgene. In time courses, we dissected the serration promoting the function of CUC2 in the leaf margin and ectopic growth inhibition by CUC2 in the leaf plate. We found that CUC2 limits growth rather by cell cycle inhibition than by cell size control. Furthermore, endogenous CUC2 was rapidly induced by CUC2-GR indicating a possible auto-inducible feedback. In contrast, EPFL2 was quickly decreased by transient CUC2 induction but increased in cuc2-3 mutant leaves suggesting that CUC2 can also counteract the EPFL2-ER pathway. Therefore, tooth growth promotion and growth inhibition by CUC2 involve partially the same mechanism but in contrary ways.
Preserving 3D Data in the OAIS Reference Model
Creators: name: Kinnaman, Alex
Publisher: name: Zenodo
Year: 2020
Subjects: digital preservation
3D preservation
OAIS
3D

description: This talk presents findings from a pilot multi-case study in archiving and preserving 3D and virtual environment data using the OAIS reference model for 3D and VR data sets. Specifically, we seek to learn new lessons from the review, evaluation and re-validation of curated 3D and VR content. We further seek to identify links between digital triage, preservation actions, and archiving in multiple disciplines in order to make recommendations to embed data stewardship processes in research ecosystems. This work happens through interdisciplinary collaboration to validate curation practices across fields to support reproducibility in research with 3D and/or VR data.  Numerous disciplines and sectors are producing 3D data for research and instruction, but without the guidance of published standards or practices generalizable across fields. In this presentation we will present our findings from taking 3D and VR data sets from three separate initiatives in distinct disciplines and creating archival objects using the OAIS reference model. Our findings review the use of OAIS as applied to preserving 3D content, and expands on what steps and information on 3D workflows we need to preserve in order to ensure reuse across disciplines.
description: Please see the notes in the slides for additional information and context.
Tax Expenditure and the Treatment of Tax Incentives for Investment
Creators: Redonda, Agustin
Diaz de Sarralde, Santiago
Hallerberg, Mark
Johnson, Lise
Melamud, Ariel
Rozemberg, Ricardo
Schwab, Jakob
von Haldenwang, Christian
Publisher: name: Columbia University
Year: 2018
Subjects: Tax expenditures
Tax credits
Sustainable development--Government policy

description: Governments use tax expenditures to boost investment, innovation and employment. However, these schemes are largely opaque, costly and often ineffective in reaching their stated goals. They also frequently trigger unwanted side effects. In order to improve the performance of these tools, the authors present three concrete policy proposals: First, governments should increase transparency on tax benefits. G20 members should take the lead on this with frequent and comprehensive tax expenditure reports. Second, G20 governments should improve the design of tax incentives with the aim of minimizing the generation of windfall profits and negative spillover effects within and across (in particular, on poorer) countries. Third, governments should phase out tax expenditures that are environmentally harmful, including tax incentives for fossil fuels and other schemes that promote an unsustainable use of natural resources.
title: Hydrophobic dewetting in gating and regulation of transmembrane protein ion channels
Creators: name: Yazdani, Mahdieh
name: Jia, Zhiguang
name: Chen, Jianhan
Publisher: name: University of Massachusetts Amherst
Year: 2020

description: Water is at the heart of almost all biological phenomena, without which no life that we know of would have been possible. It is a misleadingly complex liquid that exists in near coexistence with the vapor phase under ambient conditions. Confinement within a hydrophobic cavity can tip this balance enough to drive a cooperative dewetting transition. For a nanometer-scale pore, the dewetting transition leads to a stable dry state that is physically open but impermeable to ions. This phenomenon is often referred to as hydrophobic gating. Numerous transmembrane protein ion channels have now been observed to utilize hydrophobic gating in their activation and regulation. Here, we review recent theoretical, simulation, and experimental studies that together have started to establish the principles of hydrophobic gating and discuss how channels of various sizes, topologies, and biological functions can utilize these principles to control the thermodynamic properties of water within their interior pores for gating and regulation. Exciting opportunities remain in multiple areas, particularly on direct experimental detection of hydrophobic dewetting in biological channels and on understanding how the cell may control the hydrophobic gating in regulation of ion channels.
Technology and implementation science to forge the future of evidence-based psychotherapies: the PRIDE scale-up study
Creators: Wainberg, Milton L.
Gouveia, Maria Lídia
Stockton, Melissa
Feliciano, Paulino
Suleman, Antonio
Mootz, Jennifer J.
Mello, Milena
Salem, Andre Fiks
Greene, M. Claire
Bezuidenhout, Charl
Ngwepe, Phuti
Lovero, Kathryn L.
Fortunato dos Santos, Palmira
Schriger, Simone H.
Mulumba, Rogerio
Anube,  Anibal Neves
Mabunda, Dirceu
Mandlate, Flavio
Cournos, Francine
Alves Bradford, Jean-Marie
Nicholson, Terriann
Kann, Bianca
Fumo, Wilza
Duarte, Cristiane S.
Mari, Jair de Jesus
Mello, Marcelo F.
Mocumbi, Ana O.
Oquendo, Maria A.
Weissman, Myrna M.
Publisher: name: Columbia University
Year: 2021
Subjects: Psychiatry
Anxiety disorders
Depression, Mental
Psychiatric disorders
Schizophrenia
Substance abuse

description: Objective: To report the interim results from the training of providers in evidence-based psychotherapies (EBPs) and use of mobile applications. Design and setting: The Partnerships in Research to Implement and Disseminate Sustainable and Scalable Evidence (PRIDE) study is a cluster-randomised hybrid effectiveness-implementation trial comparing three delivery pathways for integrating comprehensive mental healthcare into primary care in Mozambique. Innovations include the use of EBPs and scaling-up of task-shifted mental health services using mobile applications. Main outcome measures: We examined EBP training attendance, certification, knowledge and intentions to deliver each component. We collected qualitative data through rapid ethnography and focus groups. We tracked the use of the mobile applications to investigate early reach of a valid screening tool (Electronic Mental Wellness Tool) and the roll out of the EBPs PARTICIPANTS: Psychiatric technicians and primary care providers trained in the EBPs. Results: PRIDE has trained 110 EBP providers, supervisors and trainers and will train 279 community health workers in upcoming months. The trainings improved knowledge about the EBPs and trainees indicated strong intentions to deliver the EBP core components. Trained providers began using the mobile applications and appear to identify cases and provide appropriate treatment. Conclusions: The future of EBPs requires implementation within existing systems of care with fidelity to their core evidence-based components. To sustainably address the vast mental health treatment gap globally, EBP implementation demands: expanding the mental health workforce by training existing human resources; sequential use of EBPs to comprehensively treat mental disorders and their comorbid presentations and leveraging digital screening and treatment applications. Keywords: adult psychiatry; anxiety disorders; depression & mood disorders; schizophrenia & psychotic disorders; substance misuse. © Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.
Ectopic expression of the transcription factor CUC2 restricts growth by cell cycle inhibition in Arabidopsis leaves
Creators: name: Li, Xiaoyu
name: Zheng, Yucai
name: Xing, Qian
name: Ardiansyah, Rhomi
name: Zhou, Hui
name: Ali, Shahid
name: Jing, Tingting
name: Tian, Jingjing
name: Song, Xing shun
name: Li, Yuhua
name: Müller-Xing, Ralf
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology
subject: Computational Biology

description: Plant leaf margins produce small outgrowths or teeth causing serration in a regular arrangement, which is specified by auxin maxima. In Arabidopsis, the spatiotemporal pattern of auxin dependents on both, the transcription factor CUC2 and the signal peptide EPFL2, a ligand of the growth-promoting receptor kinase ERECTA (ER). Ectopic expression of CUC2 can have contrary effects on leaf growth. Ubiquitous expressed CUC2 suppresses growth in the whole leaf, whereas cuc2-1D mutants have enlarged leaves, through ER-dependent cell proliferation in the teeth. Here we investigated the growth dynamics of cuc2-1D leaves and the growth restricting the function of CUC2 using the ubiquitous inducible CUC2-GR transgene. In time courses, we dissected the serration promoting the function of CUC2 in the leaf margin and ectopic growth inhibition by CUC2 in the leaf plate. We found that CUC2 limits growth rather by cell cycle inhibition than by cell size control. Furthermore, endogenous CUC2 was rapidly induced by CUC2-GR indicating a possible auto-inducible feedback. In contrast, EPFL2 was quickly decreased by transient CUC2 induction but increased in cuc2-3 mutant leaves suggesting that CUC2 can also counteract the EPFL2-ER pathway. Therefore, tooth growth promotion and growth inhibition by CUC2 involve partially the same mechanism but in contrary ways.
Three-Moment Approximation for the Mean Queue Time of a GI/G/1 Queue
Creators: name: Wu, Kan
name: Srivathsan, Sandeep
name: Yichi Shen
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 111714 Mental Health
subject: FOS: Health sciences

description: The approximation of a GI/G/1 queue plays a key role in the performance evaluation of queueing systems. To improve the conventional two-moment approximations, we propose a three-moment approximation for the mean queue time of a GI/G/1 queue based on the exact results of the H2/M/1 queue. The model is validated over a wide range of numerical experiments. Based on the paired t-tests, our three-moment approximation outperforms the two-moment ones when the inter-arrival time variability is greater than one.
Additional file 3 of The composite risk index based on frailty predicts postoperative complications in older patients recovering from elective digestive tract surgery: a retrospective cohort study
Creators: name: Li, Chun-Qing
name: Zhang, Chen
name: Yu, Fan
name: Li, Xue-Ying
name: Wang, Dong-Xin
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Marine Biology
subject: Mental Health
subject: Hematology

description: Additional file 3: Supplementary Table 3 Clavien-Dindo classification of postoperative complications.
Synthesis of 4-azo-butenolides
Creators: name: Pissurno, Ana Paula Da Rocha
name: Laurentiz, Rosangela Da Silva De
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: An efficient, catalyst-free, microwave-assisted approach has been developed for the synthesis of 4-azo-butyenolides derivatives by condensing tetronic acid with various anilines. This approach exhibited good functional group compatibility and produced the desired products in good to excellent yields in just 30–40 min. This approach can be seen as a better alternative to protocols with long reaction times used for the synthesis of these compounds, which are synthons for the obtaining of quinolines.
First Total Synthesis of Parvistone C and it's C8-epimer
Creators: name: Jala, Ranjith
name: Nomula, Rajesh
name: Palakodety Radha Krishna
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Marine Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Diastereoselective first total synthesis of parvistone C 1 and C8-epimer 1a are described The key features of our synthesis include Sharpless asymmetric dihydroxylation, stereoselective aryl Grignard reactions, Still-Gennari olefination and intramolecular cyclization.
Effet de la composition chimique de la solution interstitielle des matériaux cimentaires sur le transfert des ions chlorure
Creators: name: Cherif, R.
name: Hamami, A.A.
name: Aït-Mokhtar, A.
name: Meusnier, J.F.
Publisher: name: Academic Journal of Civil Engineering
Year: 2020

description: La durabilité des ouvrages en béton armé est conditionnée par le transfert des agents agressifs au sein de leurs matériaux. Parmi ces agents, un des facteurs majeurs se trouve être la diffusion des ions chlorure. Il est nécessaire donc de mieux comprendre tous les mécanismes ainsi que les interactions physico-chimiques qui interviennent lors de la diffusion de ces agents à travers les matériaux cimentaires. Il en va ainsi que la composition chimique de la solution porale des matériaux cimentaires constitue un facteur très important dans la fixation des ions chlorures. Elle a une influence directe, aussi bien sur les interactions des ions chlorures avec les autres espèces en solution, que sur leurs interactions physiques et chimiques avec la matrice cimentaire. L’originalité de ce travail est d’étudier l’évolution de la composition chimique de la solution interstitielle des matériaux cimentaires suite à une diffusion accélérée des ions chlorure.
description: Academic Journal of Civil Engineering, Vol 34 No 1 (2016): Special Issue - RUGC 2016 Liège
Social Performance Cues Induce Behavioral Flexibility in Humans
Creators: name: Toelch, Ulf
name: Bruce, Matthew J.
name: Meeus, Marius T. H.
name: Reader, Simon M.
Publisher: name: Humboldt-Universität zu Berlin
Year: 2011
Subjects: subject: aspiration level
subject: cultural transmission
subject: cumulative cultural evolution
subject: exploration–exploitation
subject: innovation
subject: performance feedback
subject: social information
subject: social learning
subject: 150 Psychologie

description: Behavioral flexibility allows individuals to react to environmental changes, but changing established behavior carries costs, with unknown benefits. Individuals may thus modify their behavioral flexibility according to the prevailing circumstances. Social information provided by the performance level of others provides one possible cue to assess the potential benefits of changing behavior, since out-performance in similar circumstances indicates that novel behaviors (innovations) are potentially useful. We demonstrate that social performance cues, in the form of previous players’ scores in a problem-solving computer game, influence behavioral flexibility. Participants viewed only performance indicators, not the innovative behavior of others. While performance cues (high, low, or no scores) had little effect on innovation discovery rates, participants that viewed high scores increased their utilization of innovations, allowing them to exploit the virtual environment more effectively than players viewing low or no scores. Perceived conspecific performance can thus shape human decisions to adopt novel traits, even when the traits employed cannot be copied. This simple mechanism, social performance feedback, could be a driver of both the facultative adoption of innovations and cumulative cultural evolution, processes critical to human success.
Flexible vs. robust lot scheduling subject to random production yield and deterministic dynamic demand
Creators: name: Helber, Stefan
name: Inderfurth, Karl
name: Sahling, Florian
name: Schimmelpfeng, Katja
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: We consider the problem of scheduling production lots for multiple products competing for a common production resource that processes the product units serially. The demand for each product and period is assumed to be known with certainty, but the yield per production lot is random because the production process can reach an out-of-control state while processing each single product unit of a lot. A service level constraint is used to limit the backlog in the presence of this yield uncertainty. We address the question of how to determine static production lots and how to schedule these lots over the discrete periods of a finite planning horizon. The scheduling problem is characterized by a trade-off between the cost of holding inventory and the cost of overtime, whereas the production output is uncertain. For this purpose, we develop a rigid and robust planning approach and two flexible heuristic scheduling approaches. In an extensive numerical study, we compare the different approaches to assess the cost of operating according to a robust plan as opposed to a flexible policy. Supplementary materials are available for this article. Go to the publishers online edition of IISE Transactions.