cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Institutional Data Use Project - University of Huddersfield
Creators: name: The Centre For Transforming Access And Student Outcomes In Higher Education (TASO)
Publisher: name: OSF Registries
Year: 2024
Subjects: subject: Education
subject: Social and Behavioral Sciences

description: This is a pre-registration of an analysis protocol to test the effectiveness of University of Huddersfield's Score As I Learn programme using a quasi-experimental design.
BOLALARDA IJOBIY SIFATLARNI SHAKLLANISHIDA XALQ ERTAKLARINING TARBIYAVIY AHAMIYATI
Creators: name: Fozilova, Odina
name: Ilyosxo'jayeva, Saodatxon
Publisher: name: Zenodo
Year: 2025

description: Maqolada oilaning farzand ta’lim-tarbiyasidagi  ahamiyati haqida so’z yuritilgan. Ertaklarning tarbiyaviy ta’siri va bolaning shaxs sifatida shakllanishidagi tutgan o’rni pedagogik-psixologik faktlar asosida yoritilgan.
Synthesis and evaluation of multitopic bisbenzothiazolyl calix[4]arenes for ionic toxicants
Creators: name: Lakhbeer Singh Arora
name: Chawla, Har Mohindra
name: Nalin Pant
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Two new benzothiazolyl calix[4]arene-based multitopic molecular receptors L-1 and L-2 have been synthesised and evaluated for recognition of ionic toxicants. The receptors selectively interact with copper, silver and fluoride ion toxicants as assessed through UV-visible, NMR and colorimetric techniques. The stability of L-1:Cu+2 and L-2:Cu+2 complexes was found to be higher than that of complexes formed with Ag+ and F– complexes in the presence of trifluoroacetic acid. Superiority of L-1 over L-2 for analysis of identified toxicants has been determined by measurement of binding constants.
Аргиназа - новая мишень для фармакологической коррекции эндотелиальной дисфункции
Creators: name: Якушев В. И.
name: Покровский М. В.
name: Корокин М. В.
name: Покровская Т. Г.
name: Куликовская В. А.
name: Ершов И. Н.
name: Бесхмельницына Е. А.
name: Арустамова А. А.
name: Котельникова Л. В.
Publisher: name: Научные ведомости Белгородского государственного университета. Серия: Медицина. Фармация
Year: 2012
Subjects: L-АРГИНИН
АРГИНАЗА I
АРГИНАЗА II
ЭНДОТЕЛИАЛЬНАЯ ДИСФУНКЦИЯ
ДИАБЕТ
ГИПЕРТЕНЗИЯ
ЭНДОТЕЛИАЛЬНАЯ СИНТАЗА ОКСИДА АЗОТА

description: Аргиназа катализирует гидролиз L-аргинина, субстрата для синтеза оксида азота, до L-орнитина и мочевины. В организме человека обнаружены две изоформы аргиназы. Аргиназа I локализуется в цитоплазме клеток и экспрессируется преимущественно в печени. Аргиназа II это митохондриальный белок, который экспрессируется в почках, простате, сосудистой стенке. Аргиназа II гидролизирует L-аргинин, снижая тем самым синтез оксида азота, приводит к развитию эндотелиальной дисфункции и возникновению целого ряда кардиваскулярной патологии.
A Hilbert Space Approach to the Collatz Conjecture Problem Using an Infinite-Dimensional Operator
Creators: name: Kartomin, Nikita
Publisher: name: Zenodo
Year: 2024
Subjects: subject: Functional analysis

description: This paper explores an approach to the Collatz conjecture through the lens of functional analysis. We construct an infinite-dimensional operator T on the l^2 Hilbert space, where the basis vectors represent natural numbers. By analyzing the spectral properties of T, we provide insights into the conjecture's behavior. The compactness of  T^(inf) suggests a finite-dimensional limit for the image of the operator under infinite applications, mapping the space onto a subspace characterized by the numbers 1, 2, and 4.
title: The roles of parent material, climate, and geomorphology in soil organic carbon response to short-term climate change in moist boreal forests
Creators: name: Patrick, Mackenzie E.
Publisher: name: Memorial University of Newfoundland
publisherIdentifier: https://ror.org/04haebc03
publisherIdentifierScheme: ROR
Year: 2024

description: Boreal forests store significant soil organic carbon (SOC) where increasing temperature and extreme precipitation are expected with climate change. Yet, the impact on subsoil SOC is unclear. Dissolved organic matter (DOM) facilitates Al weathering to precipitate Al organo-metal complexes (AlOMC) that stabilize mineral horizon SOC. An enhanced DOM input is expected with climate change, however, a high water-flux associated with extreme precipitation may limit AlOMC precipitation. This thesis investigates the roles of parent material composition, climate and geomorphology in boreal SOC dynamics using climate and hillslope transects to enhance: (1) subsoil SOC predictions and (2) its response to short-term climate change. A SOC content predictive model was developed using soils from four climate regions with varying parent material. Unsurprisingly, AlOMC content was the main predictor, with greater SOC in regions with high Al availability. Further interactions with depth-dependent factors, C saturation of AlOMC (C:AlOMC) and their proportion of SOC, suggested infiltration depth is key within a region. As such, greater SOC is supported on gentle slopes via deeper infiltration. Controls on SOC response to extreme precipitation were evaluated experimentally with increasing soil moisture to emulate events occurring on dry summer soils to wet late autumn soils. Antecedent soil moisture and C:AlOMC controlled SOC response under high water flux regardless of parent material or climate. I present a simple predictive model demonstrating shallow SOC loss but deeper storage potential, with greater potential on gentle slopes. Further, enhanced loss from dry soils indicates late summer SOC is most vulnerable to loss (~1‰). Therefore, event timing and infiltration depth are key for SOC response to extreme precipitation. Weathering profiles (mass transfer coefficients), AlOMC and SOC distributions suggest that Al availability sets the water flux threshold for AlOMC precipitation. Extreme events surpass this threshold, limiting new SOC storage. Enhanced SOC storage is expected with an increasing DOM flux with climate change in Al-rich regions supporting higher AlOMC precipitation thresholds, while Al-poor regions may experience SOC loss. These results find regional parent material overrides climate controls on boreal SOC, and this will inform carbon feedbacks to improve Earth Systems models.
Non-Abelian hyperbolic band theory from supercells
Creators: name: Lenggenhager, Patrick M.
name: Maciejko, Joseph
name: Bzdušek, Tomáš
Publisher: name: arXiv
Year: 2023
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Wave functions on periodic lattices are commonly described by Bloch band theory. Besides Abelian Bloch states labeled by a momentum vector, hyperbolic lattices support non-Abelian Bloch states that have so far eluded analytical treatments. By adapting the solid-state-physics notions of supercells and zone folding, we devise a method for the systematic construction of non-Abelian Bloch states. The method applies Abelian band theory to sequences of supercells, recursively built as symmetric aggregates of smaller cells, and enables a rapidly convergent computation of bulk spectra and eigenstates for both gapless and gapped tight-binding models. Our supercell method provides an efficient means of approximating the thermodynamic limit and marks a pivotal step towards a complete band-theoretic characterization of hyperbolic lattices.
description: 5 pages (5 figures) + references + 19 pages of Supplemental Material (10 figures + 2 tables); (v2) updated with accepted version
title: 02_1293
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
ทัศนคติ แรงจูงใจ และความชื่นชอบในการบริโภคสื่อของนักศึกษาที่มีพฤติกรรมการแต่งกายเลียนแบบสื่อบันเทิงเกาหลี
Creators: name: พงษ์ทัช จิตวิบูลย์, เกษตรชัย และหีม
Publisher: name: สำนักวิทยบริการ มหาวิทยาลัยสงขลานครินทร์ วิทยาเขตปัตตานี
Year: 2020
Subjects: พฤติกรรมการเลียนแบบ, การแต่งกาย, สื่อบันเทิงเกาหลี, imitation behavior, dressing, Korean entertainment media

description: วารสารวิทยบริการ มหาวิทยาลัยสงขลานครินทร์, 31, 1, 209-220
Towards a policy framework for pro-poor payment for environmental services in Vietnam
Creators: name: Thuy, Pham Thu
Publisher: name: Charles Darwin University
Year: 2011

description: Payment for Environmental Services (PES) is a relatively new concept in Vietnam. The government has recognised its potential to help the rural poor emerge from poverty. This research analyses the feasibility of and challenges to pro-poor PES in Vietnam and provides recommendations for improvement. Data were collected and analysed using participatory and group techniques, qualitative data analysis and case study approaches. Overall, this thesis reveals that organisational barriers (lack of coordination amongst stakeholders, benefit allocation, high transaction costs, top-down planning and control); institutional barriers (lack of specific regulations, inadequate involvement of the poor in PES implementation, low levels of payment, insecure land tenure); and lack of knowledge and capacity among public servants, impede implementation of pro-poor PES in Vietnam. Complex project administration, conflicts among actors and a limited number of buyers of environmental services (ES) affect pro-poor PES outcomes at a local level. Donors currently play a large role in supporting PES schemes. Prices for ES would not be financially viable had transaction costs not been covered by donors. Availability of income and technical assistance to poor households is only possible through donors wanting to fund pro-poor PES projects. Participation by poor households is limited due to political factors, contracts being driven by buyers, and the limited capacity of households to negotiate and manage PES schemes. At most studied sites, intermediaries were instrumental in negotiating PES. However, the work of intermediaries was rarely flawless as self interest could override impartiality resulting in less than optimal PES outcomes. For pro-poor PES to succeed in alleviating poverty in Vietnam, a number of key elements need to be factored into the development and administration of pro-poor PES programs. Programs need to be: participatory so that all players are given fair and ample opportunity to partake in the program (particularly the least well-resourced and most economically disenfranchised); transparent so that all players can be made aware of the way in which the program is administered, including distribution of benefits; well-monitored to ensure that the program is conducted in a manner that meets the program's overarching objectives and guidelines.
Influence of local environmental conditions and bleaching histories on the diversity and distribution of Symbiodinium in reef-building corals in Tanzania
Creators: name: LJ Chauka
name: G Steinert
name: MSP Mtolera
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Pollution, turbidity and coral bleaching history, as well as coral diversity, vary along the Tanzanian coastline. Prior to this study, it was not known whether exposure to such environmental variation might have influenced the diversity and distribution of Symbiodinium along this coastline. Such information can provide insight into whether Tanzanian reef-building corals develop adaptation to current trends of climate change. Here, 10 reef-building coral samples were collected from different reefs along the Tanzanian coast with different micro-environments and bleaching histories. The ITS-2 region of ribosomal DNA was employed in the characterisation of Symbiodinium harboured by reef-building corals. DGGE fingerprints and DNA sequences showed that most coral species host a single Symbiodinium type, which is maintained throughout the coast regardless of local environmental differences. We present polymorphic symbioses in Acropora spp., Millepora sp. and Galaxea fascicularis in mainly turbid and warm environments as a sign of adaptation to harsh conditions. However, such adaptation may not provide marked resistance to bleaching because Acropora is a bleaching-susceptible genus.
title: Comparison of various mucoadhesive gelling agents fordevelopment of an immunosuppressant for the oral cavity
Creators: name: Hoffreiter, Alexander
name: Lunter, Dominique
Publisher: name: Fachinformationsdienst für Pharmazie
Year: 2024
Subjects: subject: 615
subject: 610

description: Tacrolimus (FK 506) is a potent immunosuppressive agent used in the treatment of many immunogenic diseases (e.g. orally administered for the prevention of transplant rejection or as an ointment against immunogenic skin reactions). Immunosuppression is also required in the oral cavity to combat oral lichen planus or severe gingivitis, among others. Orally administered FK 506 exhibits several severe adverse drug reactions due to systemic effects and the ointment intended for dermal use cannot be applied to the buccal mucosa due to its hydrophobicity. Unfortunately, no preparation for buccal use exists on the market, yet. Therefore, a semi-solid mucoadhesive formulation intended to provide a local effect to the buccal mucosa was developed. Due to Tacrolimus being expensive, in order to carry out many preliminary tests ibuprofen (IBU) was chosen as model active due to its similarly poor water solubility and comparable logP value. To evaluate the suitability of different gelling agents, chitosan as a positively, hydroxypropyl methylcellulose (HPMC) as an uncharged and carbomer as negatively charged mucoadhesive polymer were used. Mucosa from porcine esophagus was used as a surrogate for buccal human mucosa due to their similar composition in the mucosa layer. The formulations were prepared with the gelling agents and IBU as suspension gels. Exact IBU concentration in the samples was measured by HPLC. A material tester was successfully used to test force and work of adhesion to the mucosa. Furthermore, a custom-made cell with a defined artificial saliva flow rate was used to test resistance against saliva. To enable systematic comparison of adhesion and mucoadhesion between chitosan, HPMC and carbomer, gels with the same zero shear viscosity were tested. Finally, a formulation with optimal mucoadhesion was obtained.
Ecology, ecophysiology and biogeography of the monsoon rainforest tree, Allosyncarpia ternata (S.T. Blake)
Creators: name: Fordyce, Ian
Publisher: name: Charles Darwin University
Year: 1998

description: Allosyncarpia ternata S.T. Blake is a large tree endemic to a small area (25 000 km2) in the "Top End" of the Northern Territory, Australia. Within this area, A. ternata dominates the canopy in a variety of topographic settings and vegetation types, from closed-canopy rainforest in ravines to low woodland on cliffs and hilltops. This study examines some of the differences in A. ternata plants at micro-climatically contrasting sites in the Baroalba Springs - Koongarra Saddle area in Kakadu National Park. At cliff and hilltop sites, trees were generally shorter and more frequently multi-stemmed than trees on the ravine floor. These differences were associated with site differences in dry-season water availability, and were accompanied by differences in stomatal conductance, leaf xylem potential and leaf solute potential. Site differences in leaf characteristics and leaf assimilation rates were typical of sun vs shade leaves and were probably related to the average irradiance experienced during growth. Allosyncarpia ternata's ability to occupy such a variety of habitats is probably due largely to its plasticity in leaf characteristics and tree physiognomy, which maintain photosynthetic activity under variable light conditions and throughout seasonal drought. This wide ecological amplitude, together with the plant's evident success in urban plantings, suggests that A. ternata adults and "established" seedlings have the physiological capacity to occupy a larger part of the continent than they do at present. Dispersal and germination of A. ternata seeds, and the establishment, growth and survival of seedlings, were monitored in Allosyncarpia forest over a five-year period. Field and shadehouse trials demonstrated that "young" seedlings (i.e. those without a substantial lignotuber) are extremely vulnerable to drought and fire. It is speculated that, although habitats suitable for A. ternata might exist elsewhere in the Top End, the species is unable to disperse to them.
Cultural foundation of the Yidaki in Northeast Arnhem Land
Creators: name: Graves, Randin
Publisher: name: Charles Darwin University
Year: 2006

description: The didjeridu, or yiaki as it is commonly known in northeast Arnhem Land, is a musical instrument that originated in the far north of Australia, but since European contact has developed into a widely recognized symbol for the whole of Australia and a tool of self-expression for many throughout the world. Many Aboriginal People have expressed concern about the instrument's spread out of their control and without understanding or respect for its traditional origins. Some, such as those behind the 1999 Garma Festival Yidaki Statement, have called for a new relationship between the instrument's founders and those who have appropriated the instrument for commercial or other purposes. But little has been done by either side to create this relationship. This project has sought to open a channel of communication between the Yolr)u of northeast Arnhem Land and non-Aboriginal didjeridu players. Perceptions and opinions of a sampling of didjeridu enthusiasts on the internet were collected for presentation to Yolu so that responses could be formulated and presented. Yolr)u collaborated in a process to determine what of their knowledge to share and how to present it. This thesis describes this process and its results -- Milkayrju Munur)gurr's instructional audio CD I-lard Tongue Didgeridoo and a comprehensive website at www.yirrkala.com/yidaki/dhawu to reach out from the origins to the many new users of the yiaki around the world.
Für eine "gemeinsame Digitale Zukunft" - Überlegungen zur Digitalen Geschichte
Creators: name: Donig, Simon
Publisher: name: Zenodo
Year: 2022
Subjects: Digital History
digitale Geschichte
Digital Humanities
Epistemologie
Historische Netzwerkforschung
Bildklassifizierung
Semantische Modellierung
Informationssysteme
Tiefenerschließung
Forschungsdatenmanagment

description: DE: In den letzten Jahren hat sich der "Digital Turn" zunehmend ins Zentrum unseres Fachs bewegt, wie nicht zuletzt neue Denominationen für Lehrstühle und Institutsabteilungen aber auch zahlreiche Sektionen, Einzelbeiträge und kontroverse Diskussionen auf dem jüngst virtuell abgehaltenen Münchener Historikertag zeigen. Der Vortrag basiert auf einem gemeinsam mit Malte Rehbein, dem Inhaber des Lehrstuhls für Digital Humanities der Universität Passau verfassten Zeitschriftenbeitrag und reflektiert die Auswirkungen der Digitalen Transformation für die Geschichtswissenschaft. EN: In recent years, the "digital turn" has increasingly gravitated towards the center of our discipline, as can be seen not only in new denominations for chairs and institute departments, but also in numerous sections, individual contributions, and controversial discussions at the recent virtual Munich Historians' Day. The presentation is based on a journal article co-authored with Malte Rehbein the holder of the Chair of Digital Humanities at the University of Passau and reflects on the implications of the Digital Transformation for historical scholarship.
การศึกษาความผสานของพื้นที่ต่อเมืองและความสามารถในการเข้าใจเมืองของย่านซอยท่าน้ำเจ้าพระยาในเขตกรุงเทพมหานคร
Creators: name: ปณัฐพรรณ ลัดดากลม
Publisher: name: สำนักวิทยบริการ มหาวิทยาลัยสงขลานครินทร์ วิทยาเขตปัตตานี
Year: 2020
Subjects: ความผสานของพื้นที่, ความสามารถในการเข้าใจเมือง, สเปซซินแทค, ย่านซอยท่าน้ำเจ้าพระยา, synergy, intelligibility, space syntax, Chao Phraya riverside alley areas

description: วารสารวิทยบริการ มหาวิทยาลัยสงขลานครินทร์, 31, 1, 221-232
วัดไทยบนแหลมมลายูกับการสร้างพื้นที่พหุวัฒนธรรม
Creators: name: ปัญญา เทพสิงห์, ธงพล พรหมสาขา ณ สกลนคร
Publisher: name: สำนักวิทยบริการ มหาวิทยาลัยสงขลานครินทร์ วิทยาเขตปัตตานี
Year: 2020
Subjects: วัดไทย, การสร้าง, พหุวัฒนธรรม, แหลมมลายู, Thai temples, creation, multicultural, Malay Peninsula

description: วารสารวิทยบริการ มหาวิทยาลัยสงขลานครินทร์, 31, 1, 233-242
Effects of relative humidity and particle and surface properties on particle resuspension rates
Creators: name: Yoojeong Kim
name: Wellum, Glyn
name: Kerrianne Mello
name: Strawhecker, Kenneth E.
name: Thoms, Richard
name: Giaya, Arjan
name: Wyslouzil, Barbara E.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 60506 Virology

description: Wind tunnel experiments examined the coupled effects of relative humidity (RH) and surface and particle properties on aerodynamically induced resuspension. Hydrophilic glass spheres and hydrophobic polyethylene spheres ∼20 μm in diameter, with nanoscale surface features, were resuspended from hydrophilic glass, hydrophobic chemical agent resistant coating (CARC), and gold surfaces. Roughness of the glass and gold surfaces was on the nanoscale, whereas CARC surfaces had microscale roughness. Different particle–surface combinations yielded van der Waals interactions that varied by a factor of 4, but these differences had a relatively minor effect on resuspension. Wind tunnel RH was varied between 7% and 78%. Overall, RH affected the resuspension of hydrophilic particles on hydrophilic surfaces most strongly and that of hydrophobic particles on hydrophobic surfaces the least. For each particle–surface combination there was a threshold RH value below which resuspension rates were essentially constant and in good agreement with a dimensionless model of particle resuspension. Copyright © 2016 American Association for Aerosol Research
Effects of relative humidity and particle and surface properties on particle resuspension rates
Creators: name: Yoojeong Kim
name: Wellum, Glyn
name: Kerrianne Mello
name: Strawhecker, Kenneth E.
name: Thoms, Richard
name: Giaya, Arjan
name: Wyslouzil, Barbara E.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 60506 Virology

description: Wind tunnel experiments examined the coupled effects of relative humidity (RH) and surface and particle properties on aerodynamically induced resuspension. Hydrophilic glass spheres and hydrophobic polyethylene spheres ∼20 μm in diameter, with nano-scale surface features, were resuspended from hydrophilic glass, hydrophobic chemical agent resistant coating (CARC) and gold surfaces. Roughness of the glass and gold surfaces was on the nanoscale, whereas CARC surfaces had microscale roughness. Different particle–surface combinations yielded van der Waals interactions that varied by a factor of four, but these differences had a relatively minor effect on resuspension. Wind tunnel RH was varied between 7–78%. Overall, RH affected the resuspension of hydrophilic particles on hydrophilic surfaces most strongly and that of hydrophobic particles on hydrophobic surfaces the least. For each particle/surface combination there was a threshold RH value below which resuspension rates were essentially constant and in good agreement with a dimensionless model of particle resuspension.
title: Calendrier des ateliers du numérique du 1er semestre 2015
Creators: name: LabexMed
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2017

description: Calendrier des ateliers du numérique du 1er semestre 2015
description: Relation: http://labexmed.hypotheses.org/1279
Identification and characterisation of serine protease inhibitors from Araucaria angustifolia seeds
Creators: name: Alves, Flávio Lopes
name: Sallai, Roberto C.
name: Salu, Bruno R.
name: Miranda, Antonio
name: Oliva, Maria Luiza V.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer

description: Araucaria angustifolia seeds are characterised by a relatively high content of starch and protein. This study aimed to verify the presence of α-amylase inhibitors in the seeds and to characterise a trypsin inhibitor found in the embryo tissues. Inhibitor purification was carried out by the saline extraction of proteins, acetone precipitation and affinity chromatography. Two protein bands of molecular weight estimated by SDS-PAGE at about 35 kDa were further examined by high-performance liquid chromatography coupled to a mass spectrometer and were shown to be 36.955 Da (AaTI-1) and 35.450 Da (AaTI-2). The sequence of the N-terminal region shows that AaTI-1 and AaTI-2 are structurally similar to plant inhibitors of the serpin family. A mixture of AaTI-1 and AaTI-2, identified as AaTI, shows selectivity for the inhibition of trypsin (Kiapp 85 nM) and plasmin (Kiapp 7.0 μM), but it does not interfere with the chymotrypsin, human plasma kallikrein, porcine kallikrein or other coagulation enzymes activity.
title: Geosmin precursor germacradienol is produced by a terpene cyclase from Aspergillus ustus
Creators: name: Peter, Marlies
name: Yang, Yiling
name: Li, Shu-Ming
Publisher: name: Fachinformationsdienst für Pharmazie
Year: 2024
Subjects: subject: 615
subject: 610

description: The powerful odor geosmin is a non-canonical terpenoid with C12 skeleton which can be smelled after rain fall or in dug earth. Its biosynthesis is conserved in bacteria, a bifunctional sesquiterpene cyclase catalyses both the formation of its intermediate precursor germacradienol and the conversion to geosmin in two subsequent ionisation- and metal-dependent steps starting with the cyclisation of farnesyl diphosphate (FPP). In comparison to a variety of bacterial species, little is known about its biosynthesis in eukaryots like fungi and plants. Terpene cyclases function as geosmin synthases from basidiomycetes are reported but not for ascomycetes. In the genome of the ascomycetous fungus Aspergillus ustus, a putative sesquiterpene cyclase gene gdlS was identified. The respective protein shares 21 % identity on the amino acid level with the N-terminus of the germacradienol/geosmin synthase SCO6073 from Streptomyces coelicolor. Heterologous expression in Aspergillus nidulans proved gdlS coding for a germacradienol synthase, which was also confirmed biochemically. Germacradienol was identified in the enzyme assay as the sole product of GdlS in the presence of Mg2+ ions. Feeding experiments with germacradienol in A. ustus did not show any conversion to geosmin. Together with the results from phylogenetic analysis it can be proposed that the formation of germacradienol and its conversion to geosmin are catalysed in fungi by two distinct enzymes.
title: Prediction of more thermostable ApPDC variants by Constraint Network Analysis and ProteinMPNN to enable an industrial application
Creators: name: Becker, Daniel
name: Schott-Verdugo, Stephan
name: Gohlke, Holger
Publisher: name: Fachinformationsdienst für Pharmazie
Year: 2024
Subjects: subject: 615
subject: 610

description: Carbon-carbon bond-forming reactions are essential for organic synthesis. In conventional petrochemical-driven approaches, these reactions rely on organic solvents and hazardous starting materials. In contrast, biocatalysts offer an alternative pathway based on second-generation feedstocks. In particular, pyruvate decarboxylase from Acetobacter pasteurianus (ApPDC) offers a sustainable alternative in the synthesis of chiral aromatic derivatives, facilitating the C-C bond formation between, e.g., benzaldehyde and pyruvate in aqueous solution. However, ApPDC exhibits insufficient thermostability for widespread industrial application. Using molecular dynamics simulations, we generated a diverse conformational ensemble upon which we applied our in-house software, Constraint Network Analysis (CNA), to perform thermal unfolding simulations. These simulations unveiled weak spots within the protein structure. To validate our approach, we compare these identified weak spots with a previously described variant with a remarkable 12 °C enhancement in the melting point, which differs in 14 amino acid positions from the wild type. Our analysis successfully identifies 8 out of 14 specific weak spots within the ApPDC variant, underscoring the predictive capabilities of CNA in pinpointing thermal weak spots. The predicted weak spots are substituted by mutations derived from ProteinMPNN that shall enhance the stability of ApPDC. Overall 5000 sequences with a predicted enhanced thermostability were generated. This research paves the way for accelerated progress in enzyme engineering for enhanced industrial applications.
title: Comparing confocal Raman spectroscopy and tape stripping concerning the demonstration of bioequivalence of topical formulations
Creators: name: Gaiser, Annette
name: Lunter, Dominique
Publisher: name: Fachinformationsdienst für Pharmazie
Year: 2024
Subjects: subject: 615
subject: 610

description: According to the EMA the draft guideline on quality and equivalence of topical products and the guideline on the investigation of bioequivalence, bioequivalence in skin penetration research is defined as achieved if the 90 % confidence interval of the amount of drug that penetrates the skin from the generic product falls within 80 – 125 % of the amount that penetrates from the reference product. Currently, the most used technique for assessing the skin penetration in terms of bioequivalence of different formulations is tape stripping, which is destructive to the stratum corneum. The goal of our investigation was to show that confocal Raman spectroscopy (CRS), as a non-destructive technology, is a suitable alternative for establishing bioequivalence of topical drug products. Effekton, an on-the-market gel containing ketoprofen, was selected as the reference formulation. Bioequivalence was investigated by testing Effekton against itself. By diluting Effekton 1:2 with carbomer gel, a non-bioequivalent model formulation was produced and tested for validation purposes as required by the EMA. Both formulations were applied to the skin and incubated for 3 hours to test during the invasion phase. A 785 nm-wavelength NIR laser was used to perform CRS measurements. The concentration of ketoprofen was measured up to 50 μm into the skin using a 3 sec accumulation time and a spectrum captured every μm. Afterwards, tape stripping was performed and the tapes, after peeling off, sonicated in methanol to extract ketoprofen. The ketoprofen content of the resulting solutions was then quantified by HPLC. Both methods were conducted on the same skin samples in order to demonstrate a direct association between tape stripping and CRS. It was found that the two methods achieved the same relative ratios between the different formulations and thus a direct correlation was successfully demonstrated.
title: Development of Synthetic Modulators of the Nuclear Receptor LRH-1
Creators: name: Lang, Alisa
name: Schubert-Zsilavecz, Manfred
name: Merk, Daniel
Publisher: name: Fachinformationsdienst für Pharmazie
Year: 2024
Subjects: subject: 615
subject: 610

description: The nuclear receptor liver receptor homologue 1 (LRH-1) is a constitutively active ligand-activated transcription factor regulating the expression of multiple genes involved in metabolic homeostasis and inflammation. Agonists of LRH-1 might for example be used as a treatment against chronic inflammatory bowel disease or metabolic disorders. Moreover, LRH-1 overexpression was found to promote cancer development in certain tissues. To elucidate the promising therapeutic potential of LRH-1, synthetic modulators are urgently needed. Phospholipids as natural LRH-1 ligands are not suitable as chemical tools, however, and the few available synthetic LRH-1 modulator chemotypes suffer from poor physicochemical and pharmacokinetic properties. In order to close the gap of missing LRH-1 ligands as chemical tools we have screened a drug fragment library for LRH-1 modulation in vitro. One of these fragments emerged from this screening and the subsequent validation experiments as a weak LRH-1 agonist (EC50 = 46 μM, EMax = 141%) suitable for structural optimization. Systematic structure-activity relationship elucidation of this new LRH-1 ligand chemotype enabled structural optimization concerning activation efficacy and potency. The new chemotype includes excellent tool compounds with improved physico-chemical properties to probe LRH-1 and can thus contribute to a better understanding of LRH-1 and its physiological and pharmaceutical role.
Müller glia maintain their regenerative potential despite degeneration in the aged zebrafish retina.
Creators: name: Martins, Raquel R
name: Zamzam, Mazen
name: Tracey-White, Dhani
name: Moosajee, Mariya
name: Thummel, Ryan
name: Henriques, Catarina M
name: MacDonald, Ryan B
Publisher: name: The Francis Crick Institute
Year: 2022
Subjects: subject: Neurosciences
subject: FOS: Clinical medicine
subject: Model organisms
subject: Gene Expression
subject: Genetics & Genomics
subject: Developmental Biology
subject: Human Biology & Physiology
subject: Stem Cells

description: Ageing is a significant risk factor for degeneration of the retina. Müller glia cells (MG) are key for neuronal regeneration, so harnessing the regenerative capacity of MG in the retina offers great promise for the treatment of age-associated blinding conditions. Yet, the impact of ageing on MG regenerative capacity is unclear. Here, we show that the zebrafish retina undergoes telomerase-independent, age-related neurodegeneration but that this is insufficient to stimulate MG proliferation and regeneration. Instead, age-related neurodegeneration is accompanied by MG morphological aberrations and loss of vision. Mechanistically, yes-associated protein (Yap), part of the Hippo signalling, has been shown to be critical for the regenerative response in the damaged retina, and we show that Yap expression levels decline with ageing. Despite this, morphologically and molecularly altered aged MG retain the capacity to regenerate neurons after acute light damage, therefore, highlighting key differences in the MG response to high-intensity acute damage versus chronic neuronal loss in the zebrafish retina.
An experimental study to determine the obstacle height required for the control of subcritical and supercritical gravity currents
Creators: name: Pari, Seyed Amin Asghari
name: Kashefipour, Seyed Mahmood
name: Ghomeshi, Mehdi
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Turbidity currents are important phenomena involved in sediment processes in long and deep reservoirs. Deviation or dissipation of the turbidity currents in reservoirs can be achieved by using obstacles. In this paper, we study the effects of obstacle height on complete control of both subcritical and supercritical gravity currents (.7 ≤ Frd ≤ 1.37) with various inflow characteristics by means of a physical model. First, a gravity current with different concentrations and discharges without using an obstacle is measured along a flume with three different slopes. Then, the height required to block the gravity current is determined by taking into account inflow characteristics and other results reflected in the literature. Finally, using the obstacle same as embankment barrier with various heights, the effects of obstacle height on the gravity current are studied in both subcritical and supercritical flows. The results specify what obstacle height is required for complete blockage of subcritical and supercritical gravity currents.
Monitoring an effusive eruption at Piton de la Fournaise using radar and thermal infrared remote sensing data: insights into the October 2010 eruption and its lava flows
Creators: name: M. G. Bato
name: J. L. Froger
name: A. J. L. Harris
name: N. Villeneuve
Publisher: name: Geological Society of London
Year: 2016
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: Table A3 gives the parameters used for the calculation of the effusion rates.
Monitoring an effusive eruption at Piton de la Fournaise using radar and thermal infrared remote sensing data: insights into the October 2010 eruption and its lava flows
Creators: name: M. G. Bato
name: J. L. Froger
name: A. J. L. Harris
name: N. Villeneuve
Publisher: name: Geological Society of London
Year: 2016
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: Tables A1 and A2 give satellite images used in this study.
Supplementary document for Dual modality intravascular catheter system combining pulse-sampling fluorescence lifetime imaging and polarization-sensitive optical coherence tomography - 6871917.pdf
Creators: name: Bec, Julien
name: Zhou, Xiangnan
name: Villiger, Martin
name: Bouma, Brett
name: Marcu, Laura
name: Southard, Jeffrey Allen
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: Supplement 1
Monitoring an effusive eruption at Piton de la Fournaise using radar and thermal infrared remote sensing data: insights into the October 2010 eruption and its lava flows
Creators: name: M. G. Bato
name: J. L. Froger
name: A. J. L. Harris
name: N. Villeneuve
Publisher: name: Geological Society of London
Year: 2016
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: The figures give the data processing of the post-eruptive radar images.
Information and energy.pdf
Creators: name: Ising, Hartmut
Publisher: name: figshare
Year: 2016
Subjects: subject: Computer Engineering
subject: 20504 Photonics, Optoelectronics and Optical Communications
subject: FOS: Physical sciences
subject: 29999 Physical Sciences not elsewhere classified
subject: Astrophysics
subject: 89999 Information and Computing Sciences not elsewhere classified
subject: FOS: Computer and information sciences

description:
Information and Energy By Hartmut Ising A photon in a double slit experiment is carrying 1 bit of information. This was demonstrated in a gedankenexperiment by Brukner and Zeilinger. Here it is shown in a modified gedankenexperiment that Planck’s formula for the photon energy can be interpreted as the energy which is equivalent to the flux of information 1 bit/Δt and that Δt is equal to the photon’s period: E = h ν = h (1 bit) c/λ. This result is valid for an isolated photon. Based upon this result an information-energy-hypothesis is introduced for complex information. Experimental tests of the hypothetical equivalence between energy and information flux are suggested. Experimentalists with the necessary equipment are encouraged to perform such experiments as here described. This empirical approach is considered necessary as a first step on the way which could lead – if confirmed – to a quantitative theory of information physics and to experimental evidence of dark energy.
Information and energy.pdf
Creators: name: Ising, Hartmut
Publisher: name: figshare
Year: 2017
Subjects: subject: Computer Engineering
subject: 20504 Photonics, Optoelectronics and Optical Communications
subject: FOS: Physical sciences
subject: 29999 Physical Sciences not elsewhere classified
subject: Astrophysics
subject: 89999 Information and Computing Sciences not elsewhere classified
subject: FOS: Computer and information sciences

description:
Information and Energy By Hartmut Ising A photon in a double slit experiment is carrying 1 bit of information. This was demonstrated in a gedankenexperiment by Brukner and Zeilinger. Here it is shown in a modified gedankenexperiment that Planck’s formula for the photon energy can be interpreted as the energy which is equivalent to the flux of information 1 bit/Δt and that Δt is equal to the photon’s period: E = h ν = h (1 bit) c/λ. This result is valid for an isolated photon. Based upon this result an information-energy-hypothesis is introduced for complex information. Experimental tests of the hypothetical equivalence between energy and information flux are suggested. Experimentalists with the necessary equipment are encouraged to perform such experiments as here described. This empirical approach is considered necessary as a first step on the way which could lead – if confirmed – to a quantitative theory of information physics and to experimental evidence of dark energy.
title: Coastal landscapes & indigenous histories of shellfish harvesting in Atlantic Canada: Mya arenaria as a new proxy for shellfish harvesting pressure in Port Joli, Nova Scotia.
Creators: name: Predham, Ian Thomas Gordon
Publisher: name: Memorial University of Newfoundland
publisherIdentifier: https://ror.org/04haebc03
publisherIdentifierScheme: ROR
Year: 2024

description: Marine bivalves from archaeological shell middens sites reveal critical information about past environments, harvesting strategies, and human impacts on shellfish populations. However, robust sample sizes are required to develop meaningful interpretations over time and space. Port Joli, Nova Scotia (NS), has the densest concentration of shell midden deposits in Atlantic Canada, dating to ~1600 cal BP. A protocol for rapid-age at-death assessments of Mya arenaria, was developed by analysing live-collected M. arenaria to establish a baseline for interpreting archaeological shell growth patterns. Rapid-age-at-death assessments of M. arenaria reveal insights for both sclerochronological methods and archaeological interpretation. One-hundred archaeological shells were selected from six shell middens to interpret regional trends in shellfish harvesting. Chondrophores were sectioned to 3mm, mounted on slides, polished, and imaged using reflected light at 20x. Each image was analysed by four independent observers to assess: 1) quality of growth lines; 2) shell portion with the clearest lines; 3) relative age; 4) ontogenetic age; 5) season of death. Variation in growth patterns was observed between modern and archaeological specimens, with modern shells having better clarity. Further variation was observed with readability between archaeological sites and variation in the average age between sites, suggesting that some clam beds were harvested more than others. The results also demonstrate the level of experience in sclerochronology will produce more conservative age and seasonality estimates, and that novice readers are more likely to miss-characterize growth patterns.
title: Construction of Penicillium crustosum as an expression host for fungal secondary metabolite biosynthesis
Creators: name: Zhou, Jenny
name: Chen, Xiaoling
name: Li, Shu-Ming
Publisher: name: Fachinformationsdienst für Pharmazie
Year: 2024
Subjects: subject: 615
subject: 610

description: Heterologous expression of (silent/cryptic) genes and biosynthetic gene clusters (BGCs) has been proven to be one of the most promising strategies for the discovery of fungal secondary metabolites. However, successful transformation and expression of BGCs are often hindered by host-dependent factors, such as a high secondary metabolite background or low gene targeting efficiencies. Penicillium crustosum PRB-2 is a fast-growing fungus, which predominantly produces terrestric acid, clavatol, and their derivatives peniphenones and penilactones. To construct P. crustosum as an expression host with a clean secondary metabolite background, the two highly expressed BGCs for the production of terrestric acid and clavatol were inactivated. Furthermore, genetic manipulation in P. crustosum was facilitated by deletion of ligD to enhance gene targeting, and by deletion of pyrG and pcribo to expand the repertoire of selection markers. Finally, the commonly used Aspergillus nidulans wA integration site, consisting of the wA pigment gene and its flanking regions, was chosen for replacement of the P. crustosum pigment gene pcr4401.5 Hence, constructs designed for heterologous expression in A. nidulans can be also used for P. crustosum and transformants can be easily identified by their albino phenotypes.