cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of Adverse associations between maternal deoxynivalenol exposure and birth outcomes: a prospective cohort study in China
Creators: name: Tan, Tianqi
name: Chen, Tingting
name: Zhu, Wenwen
name: Gong, Lin
name: Yan, Yizhong
name: Li, Qian
name: Chen, Li
name: Li, Yiling
name: Liu, Jialin
name: Li, Yanan
name: Yang, Xuefeng
name: Hao, Liping
name: Wang, Huaiji
name: Yang, Nianhong
name: Wei, Sheng
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1: Fig.S1. Flowchart of the study population for analysis. Fig.S2. Scatterplot of urinary free DON (fDON) and urinary total DON (tDON), all in logarithmic scale (r = 0.810, P < 0.001). Table S1. Maternal and neonatal characteristics for the study population, urine available and unavailable subjects.a. Table S2. Associations of maternal urinary creatinine-corrected DON levels (ng/mg Creatinine) during pregnancy with birth outcomes. Table S3. Associations of maternal urinary DON levels (ng/mL) during pregnancy with the risk of low birth weight and preterm birth. Table S4. Associations of maternal urinary DON levels (ng/mL) during pregnancy with the risk of low birth weight and preterm birth.
Advancing the understanding of the role of apoptosis in lung cancer immunotherapy: Global research trends, key themes, and emerging frontiers
Creators: name: Zuo, Chun-Jian
name: Tian, Jie
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Plant Biology

description: Apoptosis is vital for improving the efficacy of lung cancer (LC) immunotherapy by targeting cancer cell elimination. Despite its importance, there is a lack of comprehensive bibliometric studies analyzing global research on apoptosis in LC immunotherapy. This analysis aims to address this gap by highlighting key trends, contributors, and future directions. A total of 969 publications from 1996 to 2024 were extracted from the Web of Science Core Collection. Analysis was conducted using VOSviewer, CiteSpace, and the R package ‘bibliometrix.’ The study included contributions from 6,894 researchers across 1,469 institutions in 61 countries, with research published in 356 journals. The volume of publications has steadily increased, led by China and the United States, with Sichuan University as the top contributor. The journal Cancers published the most articles, while Cancer Research had the highest co-citations. Yu-Quan Wei was the leading author, and Jemal, A. was the most frequently co-cited. Key research themes include “cell death mechanisms,” “immune regulation,” “combination therapies,” “gene and nanomedicine applications,” and “traditional Chinese medicine (TCM).” Future research is likely to focus on “coordinated regulation of multiple cell death pathways,” “modulation of the tumor immune microenvironment,” “optimization of combination therapies,” “novel strategies in gene regulation,” and the “integration of TCM” for personalized treatment. This is the first bibliometric analysis on the role of apoptosis in LC immunotherapy, providing an landscape of global research patterns and emerging therapeutic strategies. The findings offer insights to guide future research and optimize treatment approaches.
Synergistic effect of ultrasonication on antimicrobial activity of cecropin P1 against Escherichia coli
Creators: name: Fitriyanti, Maya
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Food packaging, preservation and processing
Food safety, traceability, certification and authenticity
Agricultural biotechnology not elsewhere classified
Microbiology not elsewhere classified

description: In this study we investigate the synergistic effect of low frequency ultrasonication (14, 22, and 47 kHz) on antimicrobial activity of Cecropin P1 against Escherichia coli. The hypothesis was tested by comparing three different treatments (1) ultrasonication only (2) Cecropin P1 only (3) combination of both. The results showed that the combined treatment deactivate E. coli more efficiently by six order of magnitude. The mechanism of membrane permeabilization due to Cecropin P1 is also investigated using dye leakage experiment. The result indicated pore formation and carpet mechanism. Finally, a mathematical modeling is proposed to explain the synergistic effect, allowing us to make better prediction for cell deactivation.
Why the stormwater runoff matters
Creators: name: Gangelhof, Uffe L.
Publisher: name: Pan European Networks Ltd
Year: 2024
Subjects: Environment

description: Article published on INNOVATION NEWS NETWORK, a popular science website that brings the latest research and innovation news from the fields of science, environment, energy, critical raw materials, technology and electric vehicles.

 
description: D4Runoff is a Horizon Europe-funded project developing a novel framework to detect, prevent and reduce pollution in urban stormwater runoff.
title: The prevalence and importance of malaria infections during pregnancy not detected by microscopy or rapid diagnostic testing
Creators: name: Williams, JEO
Publisher: name: London School of Hygiene & Tropical Medicine
Year: 2018

description: With the advent of rapid diagnostic tests (RDT) for malaria detection, parasitological confirmation of malaria diagnoses has become more readily accessible and increasingly more affordable. However, questions are being asked about how useful they are in screening programmes, particularly for pregnant women who very often may harbour placental malaria infections which may not be detected by peripheral blood smear microscopy. It is also necessary to examine how many malaria infections go undetected by RDTs and whether such undetected infections have any negative consequences for women who carry such RDT-negative infections.
This sub-study was conducted as part of a large multi-country trial of intermittent preventive treatment with sulfadoxine pyrimethamine versus intermittent screening and treatment of malaria in pregnancy which in Burkina Faso, Gambia, Ghana and Mali. The study enrolled 5,354 primi- and secundigravidae who attended antenatal clinics at study sites in the four countries from May 2010 to October 2011.
The sensitivity of the RDT to detect peripheral malaria in pregnancy using PCR as the reference declined from 89.3% (95% CI 85.5-92.4) on the day of enrollment to 57.7% (95% CI 46.5-73.0) at delivery. However, the sensitivity of the RDT to detect placental malaria was lower when placental histology was used as the reference ranging from 72% (95% CI 63.3-79.7) for any woman who tested RDT positive at any scheduled ANC visit, to 35.4% (95% CI 26.6-45.0) at the delivery visit. The prevalence of sub-RDT malaria was highest at delivery (6.3%). There was no significant association between sub-RDT malaria infection and low birth weight. Of the women in a sub-sample who were seen at first ANC visit, 39.0% had malaria infections out of which 1.7% were non-falciparum infections presenting as mono-infections or mixed infections with P. falciparum. Clinical symptoms and signs were not sensitive enough to predict a positive RDT test and therefore the presence of malaria parasites.
Women whose malaria infections get missed by RDTs are not at great risk of developing adverse pregnancy outcomes when compared with women who had no malaria. All pregnant women should be screened with RDT if IST was considered to replace IPTp-SP in areas where SP resistance is too high or transmission intensity is very low.
The Geopolitics of Beauty
Creators: name: Gagnier, Regenia
Publisher: name: Humanities Commons
Year: 2022
Subjects: subject: Aesthetics
subject: Ecocriticism in literature
subject: Chinese literature
subject: Aesthetics, Chinese
subject: Sublime, The
subject: Ecology
subject: FOS: Biological sciences
subject: Literature
subject: Emigration and immigration
subject: Islam

description: Building on eighteenth-century philosophical traditions, Victorian aesthetics were often posed as an antidote to the vicissitudes of the Industrial Revolution and the political and economic demands of the marketplace, and in most cultures undergoing modernization the Beautiful has often functioned in opposition to the forces of power and instrumentality and their corrosive effects on social life. Readers of 19 will be familiar with the Victorian environment — the workhouses, the poverty, the invention and technology, the urbanization, the Empire. By the last decades of the nineteenth century, the Islamic world saw the dissolution of the Ottoman Empire and the effects of European colonization, and modernizing forces in China led to the greatest rejection of a 3000-year-old tradition in world history. This Forum contribution compares Western, Islamic, and Chinese aesthetics. My argument is that since the nineteenth century, modern aesthetics have typically functioned dialectically against the constraints of scarcity, exploitation, and tyranny, and that within them Nature and the natural world play a particularly valuable role, one that is threatened today in the market failure of global warming and unsustainability.
KINETIC STUDY OF ONCOGENIC PHOSPHATASE SHP2 AND ITS CORRESPONDING INHIBITORS
Creators: name: Baker, Erica Anne
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Biochemistry and cell biology not elsewhere classified
Organic chemistry not elsewhere classified

description: SHP2, a protein-tyrosine phosphatase (PTP), is a key signaling regulator in multiple cell signaling processes including the Ras/MAPK pathway. This has led to SHP2 being identified as a therapeutic target in multiple types of cancers and autoimmune disorders. However, the role that the C-terminal residues play when they interact with other SHP2 domains remains unknown. This study presents data to illustrate that the C-terminal residues interact intramolecularly with other domains to inhibit PTP activity. Additionally, the identification of a specific and potent SHP2 inhibitor has proven difficult because of the high homology and positive nature of the PTP active site. This study presents the data from a high throughput fragment screen identifying several promising HIT compounds that may be further developed into potent and selective SHP2 inhibitors. Furthermore, data supporting the development of a selective SHP2 covalent inhibitor from a nonselective core molecule is presented.
Past, present, and future of exosomes research in cancer: A bibliometric and visualization analysis
Creators: name: Xie, Yafei
name: Mi, Xingqi
name: Xing, Yikai
name: Dai, Zhangyi
name: Pu, Qiang
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Medicine
Science Policy

description: Cancer seriously threatens the lives and health of people worldwide, and exosomes seem to play an important role in managing cancer effectively, which has attracted extensive attention from researchers in recent years. This study aimed to scientifically visualize exosomes research in cancer (ERC) through bibliometric analysis, reviewing the past, summarizing the present, and predicting the future, with a view to providing valuable insights for scholars and policy makers. Researches search and data collection from Web of Science Core Collection and clinical trial.gov. Calculations and visualizations were performed using Microsoft Excel, VOSviewer, Bibliometrix R-package, and CiteSpace. As of December 1, 2024, and March 8, 2025, we identified 8,001 ERC-related publications and 107 ERC-related clinical trials, with an increasing trend in annual publications. Our findings supported that China, Nanjing Medical University, and International Journal of Molecular Sciences were the most productive countries, institutions, and journals, respectively. Whiteside, Theresa L. had the most publications, while Théry, C was the most co-cited scholar. In addition, Cancer Research was the most co-cited journal. Spatial and temporal distribution of clinical trials was the same as for publications. High-frequency keywords were “extracellular vesicle,” “microRNA” and “biomarker.” Additional, “surface functionalization,” “plant,” “machine learning,” “nanomaterials,” “promotes metastasis,” “engineered exosomes,” and “macrophage-derived exosomes” were promising research topics. Our study comprehensively and visually summarized the structure, hotspots, and evolutionary trends of ERC. It would inspire subsequent studies from a macroscopic perspective and provide a basis for rational allocation of resources and identification of collaborations among researchers.
Additional file 1 of The Network Zoo: a multilingual package for the inference and analysis of gene regulatory networks
Creators: name: Ben Guebila, Marouen
name: Wang, Tian
name: Lopes-Ramos, Camila M.
name: Fanfani, Viola
name: Weighill, Des
name: Burkholz, Rebekka
name: Schlauch, Daniel
name: Paulson, Joseph N.
name: Altenbuchinger, Michael
name: Shutta, Katherine H.
name: Sonawane, Abhijeet R.
name: Lim, James
name: Calderer, Genis
name: van IJzendoorn, David G.P.
name: Morgan, Daniel
name: Marin, Alessandro
name: Chen, Cho-Yi
name: Song, Qi
name: Saha, Enakshi
name: DeMeo, Dawn L.
name: Padi, Megha
name: Platig, John
name: Kuijjer, Marieke L.
name: Glass, Kimberly
name: Quackenbush, John
Publisher: name: figshare
Year: 2024
Subjects: subject: Statistics
subject: FOS: Mathematics

description: Additional file 1: Text S1. Summary of netZoo methods. Figure S1. Elastic net coefficients of regorafenib drug sensitivity regression on TF targeting. The analysis includes all 1,132 TFs modeled in the GRNs of 76 melanoma cell lines. The tails of this distribution are represented in Fig. 2B. Figure S2. Correlating TCA cycle metabolite and enzyme levels to infer pathway direction. Figure S3. Absolute LDH protein levels do not convey the underlying metabolic network. Figure S4. Reconstruction of a multi-omic partial correlation network using DRAGON. Figure S5. Timeline of netZoo methods’ publications. Table S1. Input data for netZoo methods. Table S2. Pairwise combinations of multi-omic data to build a CCLE integrated partial correlation network. Table S3. Resources table. Data used for the various analysis presented in the main text is presented in the following table. Table S4. Experimental design and statistical methods for the analyses presented in the main text. Table S5. Genes names of 1,132 TFs modeled in CCLE GRNs.
sj-pdf-3-mde-10.1177_23821205211030176 – Supplemental material for The Development of Empathy and Associated Factors during Medical Education: A Longitudinal Study
Creators: name: Kötter, Thomas
name: Kiehn, Leevke
name: Obst, Katrin Ulrike
name: Voltmer, Edgar
Publisher: name: SAGE Journals
Year: 2021
Subjects: Education

description: Supplemental material, sj-pdf-3-mde-10.1177_23821205211030176 for The Development of Empathy and Associated Factors during Medical Education: A Longitudinal Study by Thomas Kötter, Leevke Kiehn, Katrin Ulrike Obst and Edgar Voltmer in Journal of Medical Education and Curricular Development
sj-pdf-3-gcq-10.1177_00169862211032987 – Supplemental material for Psychological Well-Being of Intellectually and Academically Gifted Students in Self-Contained and Pull-Out Gifted Programs
Creators: name: Cash, Trent N.
name: Lin, Tzu-Jung
Publisher: name: SAGE Journals
Year: 2021
Subjects: Education

description: Supplemental material, sj-pdf-3-gcq-10.1177_00169862211032987 for Psychological Well-Being of Intellectually and Academically Gifted Students in Self-Contained and Pull-Out Gifted Programs by Trent N. Cash and Tzu-Jung Lin in Gifted Child Quarterly
sj-pdf-4-gcq-10.1177_00169862211032987 – Supplemental material for Psychological Well-Being of Intellectually and Academically Gifted Students in Self-Contained and Pull-Out Gifted Programs
Creators: name: Cash, Trent N.
name: Lin, Tzu-Jung
Publisher: name: SAGE Journals
Year: 2021
Subjects: Education

description: Supplemental material, sj-pdf-4-gcq-10.1177_00169862211032987 for Psychological Well-Being of Intellectually and Academically Gifted Students in Self-Contained and Pull-Out Gifted Programs by Trent N. Cash and Tzu-Jung Lin in Gifted Child Quarterly
sj-pdf-5-gcq-10.1177_00169862211032987 – Supplemental material for Psychological Well-Being of Intellectually and Academically Gifted Students in Self-Contained and Pull-Out Gifted Programs
Creators: name: Cash, Trent N.
name: Lin, Tzu-Jung
Publisher: name: SAGE Journals
Year: 2021
Subjects: Education

description: Supplemental material, sj-pdf-5-gcq-10.1177_00169862211032987 for Psychological Well-Being of Intellectually and Academically Gifted Students in Self-Contained and Pull-Out Gifted Programs by Trent N. Cash and Tzu-Jung Lin in Gifted Child Quarterly
title: ICOS Ecosystem Instructions for AccuPAR LP-80 Ceptometer Instrument Use
Creators: name: Op de Beeck, Maarten
name: Sabbatini, Simone
name: Papale, Dario
Publisher: name: ICOS Ecosystem Thematic Centre
Year: 2017
Subjects: ecosystem protocols
GAI
AccuPAR

description: This document explains Green Area Index measurements with the AccuPAR LP-80 PAR/LAI Ceptometer, here simply called AccuPAR, at ICOS ecosystem stations. It describes how to set up the instrument and how to carry out the measurements at each measurement plot following the spatial scheme explained in the Instructions documents for Ancillary Vegetation Measurements. It also explains how output files from the instrument are structured.
Simple methods for estimating the maximum 24-hour urinary potassium excretion in kidney failure without replacement therapy patients
Creators: name: Zhang, Danyang
name: Wang, Yukun
name: Jiang, Shimin
name: Li, Wenge
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Marine Biology
subject: Hematology

description: Adjusting dietary potassium intake based on 24-hour urinary potassium excretion is the primary method of preventing hyperkalemia. Currently, there is no accurate and convenient method for calculating maximum 24-hour urinary potassium excretion in kidney failure without replacement therapy patients. We developed and validated two new models to assess the upper limit of dietary potassium consumption in this high-risk cohort, using the maximum 24-hour urinary potassium excretion as a proxy. The data of 145 kidney failure without replacement therapy patients with hyperkalemia was gathered. The prediction models were developed using multilayer perceptron and stepwise multiple linear regression utilizing a stochastic sample of 102 (70%) patients. Within the rest 43 (30%), the performance of various models was independently verified. The two new models had low bias (-0.02 and −0.57 mmol/24h vs 66.74 and 79.91 mmol/24h, mean absolute error = 5.57 and 5.22 vs 68.95 and 81.37), high accuracy (percentage of calculated values within_±30% of measured values = 83.45% and 84.14% vs 0.00% and 0.00%), high correlation with measured values (Spearman correlation coefficient = 0.72 and 0.72 vs 0.46 and 0.45, intraclass correlation coefficient = 0.67 and 0.70 vs 0.03 and 0.03) and high agreement with 24-hour urine potassium measurements (95% limits of agreement of Bland-Altman plot = 13.70 and 13.20 mmol/24h vs 113.8 and 191.3 mmol/24h). These new models show high clinical application value for the calculation of maximum 24-hour urinary potassium excretion in kidney failure without replacement therapy patients with hyperkalemia.
sj-pdf-6-gcq-10.1177_00169862211032987 – Supplemental material for Psychological Well-Being of Intellectually and Academically Gifted Students in Self-Contained and Pull-Out Gifted Programs
Creators: name: Cash, Trent N.
name: Lin, Tzu-Jung
Publisher: name: SAGE Journals
Year: 2021
Subjects: Education

description: Supplemental material, sj-pdf-6-gcq-10.1177_00169862211032987 for Psychological Well-Being of Intellectually and Academically Gifted Students in Self-Contained and Pull-Out Gifted Programs by Trent N. Cash and Tzu-Jung Lin in Gifted Child Quarterly
Legionnaires' disease in Europe, 2009-2010
Creators: name: Beauté, J.
name: Zucs, Phillip
name: Jong, B. De
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2013
Subjects: subject: Humans
subject: Female
subject: Male
subject: Adult
subject: Middle Aged
subject: Age Distribution
subject: Cluster Analysis
subject: Demography/statistics & numerical data
subject: Demography/trends
subject: Disease Notification/statistics & numerical data
subject: Europe/epidemiology
subject: Legionella pneumophila/isolation & purification
subject: Legionella pneumophila/pathogenicity
subject: Legionnaires' Disease/epidemiology
subject: Legionnaires' Disease/microbiology
subject: Legionnaires' Disease/transmission
subject: Population Surveillance
subject: Seasons
subject: Sex Distribution
subject: Travel/statistics & numerical data
subject: Travel/trends
subject: 610 Medizin

description: The surveillance of Legionnaires’ disease (LD) in Europe is carried out by the European Legionnaires’ Disease Surveillance Network (ELDSNet) and coordinated by the European Centre for Disease Prevention and Control (ECDC). All cases reported in 2009 and 2010 and meeting the European case definition were electronically transmitted to The European Surveillance System (TESSy) database. A total of 5,551 and 6,305 cases were reported by 29 European countries in 2009 and 2010, respectively. The age-standardised rate of all cases was 1.20 per 100,000 inhabitants in 2010, 12% higher than in 2009, which was consistent with the increasing trend observed since 2005. Most of this increase consisted of community-acquired cases reported by France, Germany and the Netherlands with dates of onset in August–September. The exceptionally hot summer of 2010 in some parts of Europe may have played a role in this increase.
Additional file 2 of The Network Zoo: a multilingual package for the inference and analysis of gene regulatory networks
Creators: name: Ben Guebila, Marouen
name: Wang, Tian
name: Lopes-Ramos, Camila M.
name: Fanfani, Viola
name: Weighill, Des
name: Burkholz, Rebekka
name: Schlauch, Daniel
name: Paulson, Joseph N.
name: Altenbuchinger, Michael
name: Shutta, Katherine H.
name: Sonawane, Abhijeet R.
name: Lim, James
name: Calderer, Genis
name: van IJzendoorn, David G.P.
name: Morgan, Daniel
name: Marin, Alessandro
name: Chen, Cho-Yi
name: Song, Qi
name: Saha, Enakshi
name: DeMeo, Dawn L.
name: Padi, Megha
name: Platig, John
name: Kuijjer, Marieke L.
name: Glass, Kimberly
name: Quackenbush, John
Publisher: name: figshare
Year: 2024
Subjects: subject: Statistics
subject: FOS: Mathematics

description: Additional file 2. Review history.
sj-pdf-1-wso-10.1177_17474930211031440 - Supplemental material for Impact of stroke center certification on rt-PA thrombolysis after acute ischemic stroke in South China from 2015 to 2020
Creators: name: Chen, Yicong
name: Li, Jiaoxing
name: Dang, Chao
name: Tan, Shuangquan
name: Ouyang, Fubing
name: Li, Jianle
name: Yu, Jian
name: Zeng, Jinsheng
name: Fan, Yuhua
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Cardiology
subject: Medicine
subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-1-wso-10.1177_17474930211031440 for Impact of stroke center certification on rt-PA thrombolysis after acute ischemic stroke in South China from 2015 to 2020 by Yicong Chen, Jiaoxing Li, Chao Dang, Shuangquan Tan, Fubing Ouyang, Jianle Li, Jian Yu, Jinsheng Zeng and Yuhua Fan in International Journal of Stroke
Predominance of HA-222D/G Polymorphism in Influenza A(H1N1)pdm09 Viruses Associated with Fatal and Severe Outcomes Recently Circulating in Germany
Creators: name: Wedde, Marianne
name: Wählisch, Stephanie
name: Wolff, Thorsten
name: Schweiger, Brunhilde
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2013
Subjects: subject: Humans
subject: Germany/epidemiology
subject: Real-Time Polymerase Chain Reaction
subject: Influenza A Virus H1N1 Subtype/genetics
subject: Influenza Human/mortality
subject: Influenza Human/physiopathology
subject: Influenza Human/virology
subject: Polymorphism Genetic
subject: 610 Medizin

description: Influenza A(H1N1)pdm09 viruses cause sporadically very severe disease including fatal clinical outcomes associated with pneumonia, viremia and myocarditis. A mutation characterized by the substitution of aspartic acid (wild-type) to glycine at position 222 within the haemagglutinin gene (HA-D222G) was recorded during the 2009 H1N1 pandemic in Germany and other countries with significant frequency in fatal and severe cases. Additionally, A(H1N1)pdm09 viruses exhibiting the polymorphism HA-222D/G/N were detected both in the respiratory tract and in blood. Specimens from mild, fatal and severe cases were collected to study the heterogeneity of HA-222 in A(H1N1)pdm09 viruses circulating in Germany between 2009 and 2011. In order to enable rapid and large scale analysis we designed a pyrosequencing (PSQ) assay. In 2009/2010, the 222D wild-type of A(H1N1)pdm09 viruses predominated in fatal and severe outcomes. Moreover, co-circulating virus mutants exhibiting a D222G or D222E substitution (8/6%) as well as HA-222 quasispecies were identified (10%). Both the 222D/G and the 222D/G/N/V/Y polymorphisms were confirmed by TA cloning. PSQ analyses of viruses associated with mild outcomes revealed mainly the wild-type 222D and no D222G change in both seasons. However, an increase of variants with 222D/G polymorphism (60%) was characteristic for A(H1N1)pdm09 viruses causing fatal and severe cases in the season 2010/2011. Pure 222G viruses were not observed. Our results support the hypothesis that the D222G change may result from adaptation of viral receptor specificity to the lower respiratory tract. This could explain why transmission of the 222G variant is less frequent among humans. Thus, amino acid changes at HA position 222 may be the result of viral intra-host evolution leading to the generation of variants with an altered viral tropism.
sj-pdf-1-dst-10.1177_19322968211033868 – Supplemental material for Insulin Derived Fibrils Induce Cytotoxicity in vitro and Trigger Inflammation in Murine Models
Creators: name: Lewis, Brianne E.
name: Mulka, Adam
name: Mao, Li
name: Sharafieh, Roshanak
name: Qiao, Yi
name: Kesserwan, Shereen
name: Wu, Rong
name: Kreutzer, Don
name: Klueh, Ulrike
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: Medicine
subject: 111199 Nutrition and Dietetics not elsewhere classified

description: Supplemental material, sj-pdf-1-dst-10.1177_19322968211033868 for Insulin Derived Fibrils Induce Cytotoxicity in vitro and Trigger Inflammation in Murine Models by Brianne E. Lewis, Adam Mulka, Li Mao, Roshanak Sharafieh, Yi Qiao, Shereen Kesserwan, Rong Wu, Don Kreutzer and Ulrike Klueh in Journal of Diabetes Science and Technology
A broad assessment of rotavirus vaccine safety in infants in Korea: Insights from a data-driven signal detection approach
Creators: name: Jeong, Na-Young
name: Cho, Haerin
name: Kim, Hee-Jin
name: Choi, Nam-Kyong
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: In light of the widespread use of rotavirus vaccines, there is a pressing need to perform thorough, large-scale surveillance to actively monitor safety. This study aimed to identify potential adverse events following rotavirus vaccination in infants. Using a nationwide linked database of the national immunization registry and health insurance claims data, we identified infants vaccinated with the first dose of rotavirus vaccine between January 2016 and October 2022. The self-controlled tree‐temporal scan statistics method analyzed all incident diagnoses recorded within 56 days post-vaccination and evaluated all temporal risk windows. Among 1,720,778 rotavirus vaccine recipients 64,752 infants contributed to the analysis, yielding 72,970 incident diagnoses. Of these, 28 clusters were categorized as known adverse drug reactions (ADRs), including infection following immunization (Days 1–2, p<.001), viral infection (Days 1–5, p<.001), urticaria and erythema (Days 3–9, p<.001), acute upper respiratory infections (Days 28–42, p<.001), and pneumonia (Days 9–19 or 28–42, p<.001). Seventeen clusters were classified as ADR-related events, such as the ones clinically related to ADR or lower-level diagnostic codes of ADR. The remaining 26 clusters were classified as signals, including sepsis (Days 1–20, p<.001), meningitis (Days 1–23, p<.001), liver disease (Days 4–11, p<.001), and tubulo-interstitial nephritis (Days 11–38, p<.001). A cluster of intussusceptions was only found in monovalent vaccine-stratified analysis (Days 5–8, p  = 0.005). This study confirmed known ADRs following rotavirus vaccination, while identifying potential safety signals requiring further investigation. These findings emphasize the importance of active vaccine surveillance and underscore the need for epidemiological studies with validated outcome definitions to confirm causal relationships between rotavirus vaccination and the detected outcomes.
Factors affecting the impact of COVID-19 vaccination on post COVID-19 conditions among adults: A systematic literature review
Creators: name: Rudolph, Abby E.
name: Al Akoury, Nadine
name: Bogdanenko, Natalija
name: Markus, Kristen
name: Whittle, Isabelle
name: Wright, Olivia
name: Haridy, Hammam
name: Spinardi, Julia R.
name: McLaughlin, John M.
name: Kyaw, Moe H.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: This systematic literature review summarizes the evidence across 56 publications and pre-prints (January 2020–July 2023) with low-risk of bias based on JBI critical appraisal, that report adjusted estimates for the relationship between COVID-19 vaccination and Post-COVID-19 Condition (PCC) by timing of vaccination relative to infection or PCC-onset. Comparisons of adjusted vaccine effectiveness (aVE) against ≥1 PCC (vs. unvaccinated) across study characteristics known to impact PCC burden or VE against other COVID-19 endpoints were possible for 31 studies where vaccination preceded infection. Seventy-seven percent of pre-infection aVE estimates were statistically significant (range: 7%–95%). Statistically significant pre-infection aVE estimates were slightly higher for mRNA (range: 14%–84%) than non-mRNA vaccines (range: 16%–38%) and aVE ranges before and during Omicron overlapped. Our findings suggest that COVID-19 vaccination before SARS-CoV-2 infection reduces the risk of PCC regardless of vaccine type, number of doses received, PCC definition, predominant variant, and severity of acute infections included.
MODELING PTFE WELDING TO REDUCE CYCLE TIMES: FINITE DIFFERENCE METHOD FOR 2-D TRANSIENT HEAT CONDUCTION
Creators: name: Thompson, Joel Timothy
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Mechanical engineering not elsewhere classified

description: This project investigated the manufacturing of large diameter welded PTFE rings.This welding process is time consuming and can take over ten hours for one complete weld cycle. Additionally, the welds can have poor quality in the center of the material due to insufficient heating across the weld face. The goal of this research was to address these two issues by analyzing the current process to determine the root cause of weld failures while also determining the feasibility of reducing the weld cycle time. The scope of this thesis was to develop a model to better understand and simulate the current process which could then be used for design future improvements.
A MATLAB model of the current process was developed to simulate the transient heating cycle of the most common weld cycle for PTFE currently used by a manufacturer of PTFE seals. The data for the material properties was gathered from the manufacturer test data as well as from Lau et al. (1984). Temperature dependent material properties were used in the program because the PTFE is heated above its melting point during the weld cycle. Because of the complexity of this heat transfer problem, the heat flux in the model was tuned so that it accurately reflected the current process. This is because the goal of this study was not to determine the exact heat fluxas it was unknown, but to develop an accurate model. Thus, the heat flux was assumed and the model was then verified with process data. Results from the model were compared to validation results from a FLIR thermal camera. The model predicted the compared temperatures to within 3.1% error at both 15-minute and 90-minute intervals. Though there are many potential sources of error in the process and the thermal camera measurement, the model was deemed acceptable as a model of the current process. A semi-infinite heat analysis was calculated to simulate a hot plate welding method on the PTFE. This showed that the temperature of the weld face could be raised by 57.275°C. It is believed that a method similar to hot plate welding applied to PTFE could heat the material faster and more evenly than the current process, reducing the weld failures and cycle time.
Additional file 1 of PROMs and PREMs in routine perinatal care: mixed methods evaluation of their implementation into integrated obstetric care networks
Creators: name: Depla, Anne L.
name: Pluut, Bettine
name: Lamain-de Ruiter, Marije
name: Kersten, Anna W.
name: Evers, Inge M.
name: Franx, Arie
name: Bekker, Mireille N.
Publisher: name: figshare
Year: 2024
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences

description: Additional file1. Figure S1: Patient-reported domains and timeline of their measurement (PCB set). Table S1: Normalization Process Theory (NPT): mechanisms, subconstructs and assessment. Table S2: Full statements of the implementation survey administered to obstetric healthcare professionals to evaluate the implementation of the PCB set. Table S3: Topic guide statements for focus groups in care professionals attending QI session. Figure S2: Stacked-bar graphs of survey outcomes.
Epidemiology of hepatitis A, B and C among adults in Germany
Creators: name: Poethko-Müller, Christina
name: Zimmermann, Ruth
name: Hamouda, Osamah
name: Faber, Mirko
name: Stark, Klaus
name: Ross, R. Stefan
name: Thamm, Michael
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung; Robert Koch-Institut, Infektionsepidemiologie
Year: 2013
Subjects: subject: Health survey
subject: Hepatitis C
subject: Hepatitis B
subject: Seroepidemiology
subject: Hepatitis A
subject: 610 Medizin

description: Ten years after seroepidemiological data were obtained in the German National Health Interview and Examination Survey 1998 (GNHIES98), German Health Interview and Examination Survey (DEGS1) data contribute to a population-based, representative surveillance of hepatitis A and B immunity and of the serological markers for hepatitis C in Germany. The prevalence of antibodies against the hepatitis A virus is 48.6%. In comparison to the situation 10 years ago, seroprevalence is significantly higher among 18- to 39-year-old adults and is significantly lower in those aged 50–79 years. The association between age and seroprevalence has changed, indicating a decrease in naturally acquired hepatitis A immunity. Individual and population immunity has to be achieved through vaccination. Prevalence of hepatitis B antibodies indicates that 5.1% of adults have been exposed to the virus, significantly fewer than 10 years ago (7.9%). Prevalence of hepatitis B surface antibodies indicates that 22.9% of adults have been vaccinated against hepatitis B. Vaccination coverage has increased in all age groups and is highest in the younger age groups. These positive trends can be attributed to the general recommendation since 1995 to vaccinate against hepatitis B. For hepatitis C, the prevalence of antibodies in the general population is 0.3%. Germany thus remains a low-HCV-endemic country.
A randomized, open-label study on the effect of nipocalimab on vaccine responses in healthy participants
Creators: name: Cossu, Marta
name: Mendez, Carolina Bobadilla
name: Jackson, Amanda
name: Myshkin, Eugene
name: Liu, Grace
name: Lam, Edwin
name: Beier, Ulf H.
name: Weisel, Kathleen
name: Scott, Brittney
name: Leu, Jocelyn H.
name: Gao, Sheng
name: Dimitrova, Dessislava
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Cell Biology
subject: Neuroscience
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Nipocalimab, a human immunoglobulin G (IgG) 1 monoclonal antibody, selectively binds the IgG-binding site on the neonatal Fc receptor (FcRn) and blocks IgG recycling, reducing IgG levels without impacting antigen presentation or T-/B-cell functions. In this phase 1, open-label study, we assessed the effect of nipocalimab on IgG response in healthy adults receiving T-cell–dependent/–independent vaccines (ie, tetanus toxoid [TT], diphtheria, and acellular pertussis vaccine [Tdap] and 23-polysaccharide pneumococcal vaccine [PPSV®23], respectively). Participants received either no drug (control) or intravenous nipocalimab (30 mg/kg at Week 0; 15 mg/kg at Weeks 2 and 4). All participants received Tdap and PPSV®23 vaccinations on Day 3 and were followed through Week 16. Twenty-nine participants completed the study (active, n=15; control, n=14). All participants mounted a response to Tdap vaccination, with 3 (20%) participants in the active arm and 7 (50%) participants in the control arm achieving a positive anti-TT response at Week 4 (primary endpoint; p=.089). Nipocalimab treatment was associated with numerically lower anti-TT and anti-pneumococcal (PCP)–specific IgG responses at Week 4 but comparable responses at Weeks 2 and 16. Overall, anti-TT IgG levels remained above the protective threshold (0.16 IU/mL) for all participants, and anti-PCP IgG levels remained above the 50 mg/L threshold and showed a 2-fold increase from baseline in both arms. Nipocalimab coadministration with Tdap and PPSV®23 was safe and well tolerated. Results suggest that nipocalimab does not impact the development of IgG responses to T-cell–dependent/–independent vaccines and participants treated with nipocalimab can follow recommended vaccination schedules. Trial registration number: NCT05827874.
Additional file 1 of Integrated transcriptomic and metabolomic analyses reveals anthocyanin biosynthesis in leaf coloration of quinoa (Chenopodium quinoa Willd.)
Creators: name: Zhang, Min
name: Li, Yueyou
name: Wang, Junling
name: Shang, Shaopu
name: Wang, Hongxia
name: Yang, Xinlei
name: Lu, Chuan
name: Wang, Mei
name: Sun, Xinbo
name: Liu, Xiaoqing
name: Wang, Xiaoxia
name: Wei, Boxiang
name: Lv, Wei
name: Mu, Guojun
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 1
sj-docx-1-hol-10.1177_09596836211033202 – Supplemental material for Potential of Arabic documentary sources for reconstructing past climate in the western Mediterranean region from AD 680 to 1815
Creators: name: Meklach, Yassin
name: Camenisch, Chantal
name: Merzouki, Abderrahmane
name: Garcia Herrera, Ricardo
Publisher: name: SAGE Journals
Year: 2021
Subjects: Geography
History

description: Supplemental material, sj-docx-1-hol-10.1177_09596836211033202 for Potential of Arabic documentary sources for reconstructing past climate in the western Mediterranean region from AD 680 to 1815 by Yassin Meklach, Chantal Camenisch, Abderrahmane Merzouki and Ricardo Garcia Herrera in The Holocene
Revisar los inicios del español desde el magisterio de Alarcos y Lapesa
Creators: name: Marcos Marin, Francisco
Publisher: name: Humanities Commons
Year: 2023
Subjects: subject: Philology
subject: Basque language
subject: Arabic language
subject: Middle Ages
subject: Phonetics
subject: Historical linguistics
subject: Berber languages
subject: Latin language
subject: Alarcos Llorach, Emilio
subject: Islam

description: During the long time of its documentation, Latin could not remain unchanged, so there had to be a cultured, writ-ten variant of the language and popular variants, which evolved into dialectal forms, Afro-Latin-Romance variants. As far as the African part is concerned, the novelty of this study, especially for Romanists and Arabists, is to convey the conviction that the continuity of North African Latin can be proved until much more than the symbolic 711 and that, in the complex continuum of languages brought to Hispania by the North African occupation and subsequent triumph of Arabic and Islam, it corresponded to the Afro-Latin-Romance dialects a space of its own.
LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions
Creators: name: Desimmie, Belete A.
name: Schrijvers, Rik
name: Demeulemeester, Jonas
name: Borrenberghs, Doortje
name: Weydert, Caroline
name: Thys, Wannes
name: Vets, Sofie
name: Remoortel, Barbara Van
name: Hofkens, Johan
name: Rijck, Jan De
name: Hendrix, Jelle
name: Bannert, Norbert
name: Gijsbers, Rik
name: Christ, Frauke
name: Debyser, Zeger
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2013
Subjects: subject: Antivirals
subject: HIV replication
subject: Integrase
subject: Integrase multimerization
subject: LEDGINs
subject: 610 Medizin

description: Background: LEDGINs are novel allosteric HIV integrase (IN) inhibitors that target the lens epithelium-derived growth factor (LEDGF)/p75 binding pocket of IN. They block HIV-1 integration by abrogating the interaction between LEDGF/p75 and IN as well as by allosterically inhibiting the catalytic activity of IN. Results: Here we demonstrate that LEDGINs reduce the replication capacity of HIV particles produced in their presence. We systematically studied the molecular basis of this late effect of LEDGINs and demonstrate that HIV virions produced in their presence display a severe replication defect. Both the late effect and the previously described, early effect on integration contribute to LEDGIN antiviral activity as shown by time-of-addition, qPCR and infectivity assays. The late effect phenotype requires binding of LEDGINs to integrase without influencing proteolytic cleavage or production of viral particles. LEDGINs augment IN multimerization during virion assembly or in the released viral particles and severely hamper the infectivity of progeny virions. About 70% of the particles produced in LEDGIN-treated cells do not form a core or display aberrant empty cores with a mislocalized electron-dense ribonucleoprotein. The LEDGIN-treated virus displays defective reverse transcription and nuclear import steps in the target cells. The LEDGIN effect is possibly exerted at the level of the Pol precursor polyprotein. Conclusion: Our results suggest that LEDGINs modulate IN multimerization in progeny virions and impair the formation of regular cores during the maturation step, resulting in a decreased infectivity of the viral particles in the target cells. LEDGINs thus profile as unique antivirals with combined early (integration) and late (IN assembly) effects on the HIV replication cycle.
Elektronischer Diskurs zu Umsetzungsmöglichkeiten des Aktionsprogramms “Umwelt und Gesundheit”
Creators: name: Kaiser, U.
Publisher: name: Robert Koch-Institut
Year: 2000
Subjects: subject: Aktionsprogramm Umwelt und Gesundheit
subject: Beteiligung der Öffentlichkeit
subject: Nicht-Regierungsorganisationen (NRO)
subject: National Environmental Health Action Plan (NEHAP)
subject: public participation
subject: non-governmental organisation (NGO)
subject: 610 Medizin

description: Das Aktionsprogramm “Umwelt und Gesundheit” (APUG) hat es bisher noch nicht geschafft, in die Wahrnehmung der Öffentlichkeit und der Medien zu gelangen. Auf der Fachebene wurden bisher nur die komplexen Zusammenhänge und übergeordneten Perspektiven thematisiert. Neben weiteren Maßnahmen soll ein moderierter elektronischer Diskurs zu den Umsetzungsmöglichkeiten des APUG eine breite inhaltliche Beteiligung der Öffentlichkeit fördern, konkrete Aktivitäten auf der lokalen Ebene initiieren und somit insgesamt den notwendigen Praxisbezug herstellen.
description: Until today the “Environment and Health” action program (APUG = Aktionsprogramm “Umwelt und Gesundheit”) is not well known, neither by the public nor by the media. At the expert level only complex relationships and general points of view have been discussed. Among other actions an evaluated electronic information tool with the aim to facilitate the tasks to be performed by APUG should promote a broad public participation and initiate concrete actions on the local level. Thus it will provide the essential flow of information between the public and Environmental Health professionals.
Travel-associated Legionnaires’ disease in Europe, 2010
Creators: name: Jong, B. De
name: Hallström, L. Payne
name: Robesyn, E.
name: Ursut, D.
name: Zucs, Phillip
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2013
Subjects: subject: Humans
subject: Female
subject: Male
subject: Adolescent
subject: Adult
subject: Aged
subject: Middle Aged
subject: Risk Factors
subject: Young Adult
subject: Age Distribution
subject: Cluster Analysis
subject: Europe/epidemiology
subject: Population Surveillance
subject: Sex Distribution
subject: Travel/statistics & numerical data
subject: Aged 80 and over
subject: Incidence
subject: Disease Notification
subject: Disease Outbreaks/statistics & numerical data
subject: Legionella/isolation & purification
subject: Legionnaires' Disease/diagnosis
subject: Legionnaires' Disease/epidemiology
subject: Legionnaires' Disease/microbiology
subject: Legionnaires' Disease/transmission
subject: Polymerase Chain Reaction
subject: 610 Medizin

description: In 2010, the European surveillance network for travel-associated Legionnaires’ disease (ELDSNet, previously EWGLINET) received reports of 864 cases of travel-associated Legionnaires’ disease, of whom 24 were reported to have had a fatal outcome. As in previous years, a very low proportion of clinical isolates were obtained (45 cases, 5.6%). In the 2010 dataset, male cases outnumbered female cases by 2.6:1 and had a median age of 61 years (range: 21–96), while the median age for women was 63 years (range: 12–95). The network identified 100 new clusters in 2010, of which 44 involved only one case from each reporting country and would probably not have been detected by national surveillance schemes alone. The largest cluster (having 14 cases) was associated with a cruise ship. Legionella species were detected at 61 of the 100 accommodation site clusters investigated. The names of five accommodation sites were published on the ECDC website.