cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Robert Louis Stevenson’s South Seas Writing: Its Production and Context within the Victorian Study of Culture
Creators: name: Ratnapalan, Laavanyan
Publisher: name: Goldsmiths, University of London
Year: 2007

description: The thesis is split into two parts. The first part investigates the production, reception, and reconstruction of Robert Louis Stevenson's South Seas writing during his travels there in the years 1888-91, and its subsequent publication as In the South Seas in 1896. The second part concentrates on the findings that Stevenson makes during his Pacific travels in respect of the discourses of culture that shape the academic sciences of his day. The writing that Stevenson produces for his 'Big Book' on the cultures of the Pacific Islands is among the least-examined of all his works. His book of travel, In the South Seas, is published posthumously and contains material that is presented in a way that is not intended by the author. In the present study the reasons for this situation are investigated, and the work that the author intends to produce is recovered on the basis of the plans, notes, and photographs which remain from the period of his travels. The reconstructed work is then compared with the published volume of In the South Seas to show the extent to which textual mutilation and re-editing has significantly altered the meaning of Stevenson's original writing. In the South Seas is a text that is re-shaped by his editor in order to satisfy what is seen as a Victorian readership's desire for sentimental voyaging. Stevenson's writing is then read within the context of the Victorian study of culture as represented by Edward Burnett Tylor, to show his engagement with and criticism of some of Tylor's theories. Finally, the South Seas writing is framed within the perspective of Stevenson's reading of GWF Hegel, showing the extent to which his observations on Pacific landscapes and cultures are informed by Hegel's discussion of the antinomies of Immanuel Kant.
title: Synthesis of ROMP polymers for biological applications
Creators: name: Shehata, Sara
Publisher: name: University of Kent
Year: 2023

description: Ring opening metathesis polymerisation (ROMP) is a living polymerisation which allows for the synthesis of polymers with controlled length and composition, as well as narrow distribution of the molecular weights. Thanks to the availability of metal alkylidene catalysts at a cheap price, ROMP has become a versatile method for the preparation of materials for different applications, including optics and electronics, energy storage and nanomedicine among others. This project explored the use of ROMP for the realisation of biologically relevant polymers. In particular, ROMP has been used in two applications. The first application involved the preparation of amphiphilic block copolymers consisting of ibuprofen and PEG, which were covalently linked to the polymer backbone via a cleavable bond. Ibuprofen and PEG respectively constituted the hydrophobic and hydrophilic portions of the block copolymer. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) which was selected in this study thanks to its potential role in chemoprevention and chemotherapy. The so synthesised amphiphilic block copolymer could self-assembled in aqueous environment to form nanoparticles with precise size and morphology, and that could entrap the drug within the hydrophobic core. This allowed for the studies of the drug release from the polymeric nanoparticles using both physiological and alkaline conditions. Our studies demonstrated a high stability of the synthesised nanoparticles under physiological environments, while slow drug release could be obtained under strong basic conditions. In the second application ROMP has been used for the preparation of amphiphilic cationic polymers for the development of antimicrobial materials. Homopolymers bearing pyridinium cations and SSA (self-associating amphiphilic salts) counterions were prepared. SSAs are a novel class of antimicrobial agents synthesised by the Hiscock group at the University of Kent. In this collaboration, the so synthesised homopolymers were studied for their antimicrobial activity against both Gram-negative and Gram-positive bacteria. The results demonstrated an antagonistic effect between the amphiphilic cationic ROMP polymer and the selected SSA.
FORMASAM/ISIMIP future forest management scenarios
Creators: name: Reyer, Christopher P.O.; Schelhaas, Mart-Jan; Mäkelä, Annikki; Peltoniemi, Mikko; Gutsch, Martin; Mahnken, Mats; Loustau, Denis; Martel, Simon; Merganičová, Katarína; Meesenburg, Henning; Rötzer, Thomas; Heym, Michael; Collalti, Alessio; D'Andrea, Ettore; Matteucci, Giorgio; Ibrom, Andreas; Kvist Johannsen, Vivian
Publisher: name: Zenodo
Year: 2023

description: Future forest management scenarios for forest simulation models for 9 forest sites of the regional forest sector in ISIMIP2b
description: These forest management scenarios were prepared in the FORMASAM project. EFI Network Fund "Forest Management Scenarios for Adaptation and Mitigation" (FORMASAM) Intersectoral Impact Model Intercomparison Project (ISIMIP)
description: {"references": ["Reyer et al. 2020, https://doi.org/10.5194/essd-12-1295-2020", "Wu et al. 2013", "De Lary, 2015"]}
A thesis submitted to Addis Ababa University School of Commerce, in partial Fulfillment of the Requirement for the Award of Master of Arts Degree in Logistics and Supply Chain Management
Creators: name: TSEGAY ABADI KIDANE
Publisher: name: Zenodo
Year: 2016

description: The objective of this study is to critically assess truck transportation management practice and finding the major shortcomings of the transport services in MoND logistics main department. The study used descriptive research design in both quantitative and qualitative approach. Primary data were collected through questionnaire, interview as well as field observation. Purposive sampling technique for7interviewees and simple random sampling technique used for 186 respondents asked in the open and cloth ended questionnaire. In addition, secondary data, such as annuals evaluation reports, quarterly and monthly reports, plans, and other relevant documents of MoND-Logistics assessed and other documents like; journals, articles, research papers, was used. Methodologically, this study is in accordance to the nature of the data required and designed to be descriptive.
Low-loss mode converter for coupling light into slotted photonic crystal waveguide
Creators: name: Zhang, Xingyu
name: Subbaraman, Harish
name: Hosseini, Amir
name: Pan, Zeyu
name: Yan, Hai
name: Chung, Chi-jui
name: Chen, Ray T.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We design, fabricate and experimentally demonstrate a highly efficient adiabatic mode converter for coupling light into a silicon slot waveguide with a slot width as large as 320nm. This strip-to-slot mode converter is optimized to provide a measured insertion loss as low as 0.08dB. Our mode converter provides 0.1dB lower loss compared to a conventional V-shape mode converter. This mode converter is used to couple light into and out of a 320nm slot photonic crystal waveguide, and it is experimentally shown to improve the coupling efficiency up to 3.5dB compared to the V-shape mode converter, over the slow-light wavelength region.
description: 13 pages, 7 figures, SPIE Photonics West Conference 2014
H-ATLAS/GAMA and HeViCS - Dusty Early-Type Galaxies in Different Environments
Creators: name: Agius, N. K.
name: Alighieri, S. di Serego
name: Viaene, S.
name: Baes, M.
name: Sansom, A. E.
name: Bourne, N.
name: Bland-Hawthorn, J.
name: Brough, S.
name: Davis, T. A.
name: De Looze, I.
name: Driver, S. P.
name: Dunne, L.
name: Dye, S.
name: Eales, S. A.
name: Hughes, T. M.
name: Ivison, R. J.
name: Kelvin, L. S.
name: Maddox, S.
name: Mahajan, S.
name: Pappalardo, C.
name: Robotham, A. S. G.
name: Rowlands, K.
name: Valiante, P. Temi E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The Herschel Space Observatory has had a tremendous impact on the study of extragalactic dust. Specifically, early-type galaxies (ETG) have been the focus of several studies. In this paper we combine results from two Herschel studies - a Virgo cluster study HeViCS and a broader, low-redshift H-ATLAS/GAMA study - and contrast the dust and associated properties for similar mass galaxies. This comparison is motivated by differences in results exhibited between multiple Herschel studies of early-type galaxies. A comparison between consistent modified blackbody derived dust mass is carried out, revealing strong differences between the two samples in both dust mass and dust-to-stellar mass ratio. In particular, the HeViCS sample lacks massive ETG with as high a specific dust content as found in H-ATLAS. This is most likely connected with the difference in environment for the two samples. We calculate nearest neighbour environment densities in a consistent way, showing that H-ATLAS ETG occupy sparser regions of the local Universe, whereas HeViCS ETG occupy dense regions. This is also true for ETG that are not Herschel-detected but are in the Virgo and GAMA parent samples. Spectral energy distributions are fit to the panchromatic data. From these we find that in H-ATLAS the specific star formation rate anticorrelates with stellar mass and reaches values as high as in our Galaxy. On the other hand HeViCS ETG appear to have little star formation. Based on the trends found here, H-ATLAS ETG are thought to have more extended star formation histories and a younger stellar population than HeViCS ETG.
description: 23 pages, 16 figures, 2 tables, accepted for publication in MNRAS
Machine-learning prediction of tumor antigen immunogenicity in the selection of therapeutic epitopes
Creators: name: Savoldo, B.
name: Bixby, L.M.
name: Serody, J.S.
name: Parker, J.S.
name: Chai, S.
name: Lee, S.J.
name: Garness, J.
name: Landoni, E.
name: Field, K.
name: Vincent, B.G.
name: Washington, A.R.
name: Smith, C.C.
name: Selitsky, S.R.
Publisher: name: American Association for Cancer Research Inc.
Year: 2019

description: Current tumor neoantigen calling algorithms primarily rely on epitope/major histocompatibility complex (MHC) binding affinity predictions to rank and select for potential epitope targets. These algorithms do not predict for epitope immunogenicity using approaches modeled from tumor-specific antigen data. Here, we describe peptide-intrinsic biochemical features associated with neoantigen and minor histocompatibility mismatch antigen immunogenicity and present a gradient boosting algorithm for predicting tumor antigen immunogenicity. This algorithm was validated in two murine tumor models and demonstrated the capacity to select for therapeutically active antigens. Immune correlates of neoantigen immunogenicity were studied in a pan-cancer data set from The Cancer Genome Atlas and demonstrated an association between expression of immunogenic neoantigens and immunity in colon and lung adenocarcinomas. Lastly, we present evidence for expression of an out-of-frame neoantigen that was capable of driving antitumor cytotoxic T-cell responses. With the growing clinical importance of tumor vaccine therapies, our approach may allow for better selection of therapeutically relevant tumor-specific antigens, including nonclas-sic out-of-frame antigens capable of driving antitumor immunity.
Effect of polystyrene molecular weight on an ability to inhibit dewetting behavior of ZnO nanoparticles in polystyrene thin films
Creators: name: Kattaleeya SUJAROON
Publisher: name: Metallurgy and Materials Science Research Institute Chulalongkorn University
Year: 2020
Subjects: Polystyrene thin films
ZnO nanoparticles
Dewetting behavior

description: Journal of Metals Materials and Minerals, 30, 2, 58-66
B Cells and T Follicular Helper Cells Mediate Response to Checkpoint Inhibitors in High Mutation Burden Mouse Models of Breast Cancer
Creators: name: Martin, M.
name: Parker, J.S.
name: Hollern, D.P.
name: Thennavan, A.
name: Liu, S.
name: Serody, J.S.
name: Mott, K.R.
name: Carey-Ewend, K.
name: He, X.
name: Perou, C.M.
name: Garcia-Recio, S.
name: Garay, J.P.
name: Vick, S.C.
name: Marron, D.
name: Xu, N.
name: Glodowski, C.
name: Vincent, B.G.
name: Ford, J.
Publisher: name: Cell Press
Year: 2019

description: This study identifies mechanisms mediating responses to immune checkpoint inhibitors using mouse models of triple-negative breast cancer. By creating new mammary tumor models, we find that tumor mutation burden and specific immune cells are associated with response. Further, we developed a rich resource of single-cell RNA-seq and bulk mRNA-seq data of immunotherapy-treated and non-treated tumors from sensitive and resistant murine models. Using this, we uncover that immune checkpoint therapy induces T follicular helper cell activation of B cells to facilitate the anti-tumor response in these models. We also show that B cell activation of T cells and the generation of antibody are key to immunotherapy response and propose a new biomarker for immune checkpoint therapy. In total, this work presents resources of new preclinical models of breast cancer with large mRNA-seq and single-cell RNA-seq datasets annotated for sensitivity to therapy and uncovers new components of response to immune checkpoint inhibitors.
Geschichte der Waldungen von Dietikon
Creators: name: Heid, Karl
Publisher: name: Buchdruckerei Oscar Hummel
Year: 1958
Subjects: subject: 634 Obstanlagen, Früchte, Forstwirtschaft
subject: 949 Geschichte anderer Teile Europas
subject: Dietikon
subject: Wald
subject: Holzkorporation Dietikon
subject: Forst

description: Inhalt: Die Waldungen vor 1780 ; Der Wald nach 1800 und dessen Übergang an die Korporation ; Die Holzgerechtigkeit ; Der Nutzen des Waldes ; Rodungen des Waldes ; Vom Dorfweibel zum Holzforster ; Die Verwaltung des Waldes ; Bedeutung und Herkommen unserer Waldnamen.
Subdifferential-based implicit return-mapping operators in Mohr-Coulomb plasticity
Creators: name: Sysala, Stanislav
name: Cermak, Martin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computational Engineering, Finance, and Science (cs.CE)
subject: FOS: Computer and information sciences

description: The paper is devoted to a constitutive solution, limit load analysis and Newton-like methods in elastoplastic problems containing the Mohr-Coulomb yield criterion. Within the constitutive problem, we introduce a self-contained derivation of the implicit return-mapping solution scheme using a recent subdifferential-based treatment. Unlike conventional techniques based on Koiter's rules, the presented scheme a priori detects a position of the unknown stress tensor on the yield surface even if the constitutive solution cannot be found in closed form. This fact eliminates blind guesswork from the scheme, enables to analyze properties of the constitutive operator, and simplifies construction of the consistent tangent operator which is important for the semismooth Newton method applied on the incremental boundary value elastoplastic problem. The incremental problem in Mohr-Coulomb plasticity is combined with the limit load analysis. Beside a conventional direct method of the incremental limit analysis, a recent indirect one is introduced and its advantages are described. The paper contains 2D and 3D numerical experiments on slope stability with publicly available Matlab implementations.
description: 26 pages, 10 figures
Synthesis and characterization of ball-milled eggshell and Al2O3 reinforced hybrid green composite material
Creators: name: Shrawan KUMAR
Publisher: name: Metallurgy and Materials Science Research Institute Chulalongkorn University
Year: 2020
Subjects: Eggshell
Al2O3
Composite material
Corrosion loss
Thermal expansion

description: Journal of Metals Materials and Minerals, 30, 2, 67-75
An Immunocompetent Mouse Model of HPV16(+) Head and Neck Squamous Cell Carcinoma
Creators: name: Li, W.
name: Williams, S.E.
name: Troutman, S.
name: Selitsky, S.R.
name: Parker, J.S.
name: Kissil, J.L.
name: Hayes, D.N.
name: Carper, M.B.
name: Parag-Sharma, K.
name: Henry, E.C.
name: Wagner, B.L.
name: Byrd, K.M.
name: Montgomery, S.A.
name: Amelio, A.L.
name: Cleveland, J.L.
Publisher: name: Elsevier B.V.
Year: 2019

description: The incidence of human papilloma virus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) is increasing and implicated in more than 60% of all oropharyngeal carcinomas (OPSCCs). Although whole-genome, transcriptome, and proteome analyses have identified altered signaling pathways in HPV-induced HNSCCs, additional tools are needed to investigate the unique pathobiology of OPSCC. Herein, bioinformatics analyses of human HPV(+) HNSCCs revealed that all tumors express full-length E6 and identified molecular subtypes based on relative E6 and E7 expression levels. To recapitulate the levels, stoichiometric ratios, and anatomic location of E6/E7 expression, we generated a genetically engineered mouse model whereby balanced expression of E6/E7 is directed to the oropharyngeal epithelium. The addition of a mutant PIK3CAE545K allele leads to the rapid development of pre-malignant lesions marked by immune cell accumulation, and a subset of these lesions progress to OPSCC. This mouse provides a faithful immunocompetent model for testing treatments and investigating mechanisms of immunosuppression.
Embedded Strategies for the Sustainability Transition - Setting Priorities and Goals Aligned with Systems Resilience - EXECUTIVE SUMMARY
Creators: name: Bertels, Stephanie
name: Dobson, Rylan
Publisher: name: figshare
Year: 2020
Subjects: subject: 150199 Accounting, Auditing and Accountability not elsewhere classified
subject: FOS: Economics and business
subject: 150399 Business and Management not elsewhere classified
subject: 150303 Corporate Governance and Stakeholder Engagement
subject: 150312 Organisational Planning and Management
subject: Climate Science
subject: 49999 Earth Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Environmental Science
subject: Economics
subject: Education
subject: 140205 Environment and Resource Economics
subject: 140207 Financial Economics

description: This primer provides a summary of concepts and tools outlined more fully in our Embedded Strategies for the Sustainability Transition guide.
Building on our flagship Road to Context guide, our new Embedded Strategies guide will help you to develop a credible strategy and goals that ensure your company is doing its part to maintain the resilience of key social and environmental systems.

Embedded strategies respond to the growing calls for businesses to articulate their purpose and their strategy in alignment with a rapid climate transition, reducing systemic inequality, preserving biodiversity, and the elimination of waste.
EXPERIENCES AND CHALLENGES OF EMS TECHNICIANS IN PROVIDING PALLIATIVE AND END-OF-LIFE CARE IN THE PREHOSPITAL SETTING: A SYNTHESIS STUDY
Creators: name: Mohammad Ali Alshaike, Bandar Ali Alghamdi, Abdulaziz Saleh Alghamdi, Mohammed Saeed AL-Zahrani, Meshal Homesd Gamsh Almalki, Hassan Abdullah Hassan Tayeb, Abdulrahman Aayd Alaryani, Mohammed Faisal Al Zahrani, Alhassan Raad Nami Alsharif, Mohammed Hifthi Saeed Alkhayri
Publisher: name: Zenodo
Year: 2024

description: This synthesis study explored the experiences and challenges faced by Emergency Medical Services (EMS) technicians in providing palliative and end-of-life care within the prehospital setting. As EMS increasingly encountered patients with chronic and terminal illnesses, the integration of palliative care principles became vital for improving patient outcomes and family satisfaction. Despite the critical role of EMS, many technicians reported feeling inadequately prepared for the emotional and ethical complexities of end-of-life situations. A systematic literature review identified key themes, including the need for enhanced training, emotional and ethical strain, inconsistent care protocols, and the importance of integrating palliative care into EMS practices. The findings revealed a significant gap in formal training regarding palliative care, which led to varying care delivery and heightened emotional stress among technicians, particularly when family wishes conflicted with medical directives. Additionally, the absence of standardized protocols exacerbated these challenges and hindered effective decision-making. The study recommended the development of structured training programs, the establishment of clear guidelines for palliative care, and the fostering of collaboration between EMS and palliative care specialists. This research underscored the necessity of addressing these gaps to enhance the quality of care provided by EMS technicians and improve the overall well-being of both patients and providers during vulnerable moments in healthcare. Future research should focus on evaluating the effectiveness of training programs and implementing standardized protocols to further support EMS personnel in delivering compassionate end-of-life care.

Keywords: Emergency Medical Services (EMS), Palliative Care, End-of-Life Care, Technician Training, Systematic Literature Review
Wortschatz und Digitalisierung
Creators: name: Laura, Buechel
name: Peyer Elisabeth
name: Udry Isabelle
Publisher: name: Zenodo
Year: 2022

description: Neue Medien verändern beinahe alle Bereiche unseres Alltags, davon ist auch das Lernen neuer Sprachen nicht ausgenommen. In einem zeitgemässen Fremdsprachenunterricht werden Informationen mithilfe des Internets über Computer, Smartphones oder Tablets vermittelt. Die Liste der genutzten Kanäle ist lang und umfasst Lern-Apps, E-mail, Erklär-Videos, Blogs, Wikis oder Twitter genauso wie Online-Übersetzer, Streamingdienste, Clouds und QR Codes. Ob es sich bei dieser Fülle an Möglichkeiten um Segen oder Fluch handelt, wird bisweilen unterschiedlich eingeschätzt. Auf jeden Fall ist sie das Ergebnis einer rasanten technologischen Entwicklung der letzten Jahrzehnte. Bereits der Übergang vom Walkman (man erinnere sich...) zum MP3 Player in den 90-Jahren markierte einen Meilenstein, der Audiomaterial plötzlich viel einfacher zugänglich machte, endlich ohne Bandsalat. Verglichen mit dem Potenzial moderner Smartphones, die ab Anfang des neuen Jahrtausends den Markt erobern würden, war diese Veränderung jedoch geradezu bescheiden. Heute existieren hochleistungsfähige Geräte, mit denen Bild und Ton in bemerkenswerter Qualität aufgezeichnet, empfangen und geteilt werden können. Sprache wird so auf eine ganz neue Art verfügbar gemacht. Sprachenlernen findet jederzeit und überall statt und kann somit weitgehend individuell gestaltet werden. Gleichzeitig können sich Lernende, falls sie dies möchten, über Cloudsysteme und Internet-Plattformen miteinander vernetzen. Gerade für Englisch besteht zudem ein breites Angebot an Filmen, Games und Social Media, das zahlreiche Möglichkeiten für inzidentellen Spracherwerb eröffnet. Ausserschulischer Kontakt mit Englisch wird aktuell als eine bedeutende Lernquelle eingeschätzt (Schmitt, 2019). Der Zugang zu solchen Ressourcen ist zwar häufig frei, setzt jedoch eine angemessene Infrastruktur mit stabiler Internetverbindung und funktionierenden Geräten voraus. Dass diese Bedingungen lange nicht überall und für alle eine Selbstverständlichkeit sind, wirft auch Fragen nach fairen Bildungschancen auf......
Before and After: Comparison of Legacy and Harmonized TCGA Genomic Data Commons’ Data
Creators: name: Knijnenburg, T.A.
name: Gaheen, S.
name: The Genomic Data Analysis Network
name: Brooks, D.
name: Noble, M.S.
name: Kemal, A.
name: Chen, H.
name: Yang, L.
name: Zhou, W.
name: Robertson, A.G.
name: Hoadley, K.A.
name: Hernandez, K.M.
name: Gerhard, D.S.
name: Wang, Z.
name: Mensah, M.K.A.
name: Tarnuzzer, R.
name: Zenklusen, J.C.
name: Wang, L.-B.
name: Parker, J.S.
name: Cherniack, A.D.
name: Laird, P.W.
name: Balu, S.
name: Mungall, A.J.
name: Silva, T.C.
name: Shen, H.
name: Ding, L.
name: Demchok, J.A.
name: Reynolds, S.M.
name: Wyczalkowski, M.
name: Gao, G.F.
name: Jayasinghe, R.
name: Zhang, Z.
name: Felau, I.
name: Heiman, D.I.
name: Bailey, M.
name: Berman, B.P.
name: Liang, H.
name: Akbani, R.
Publisher: name: Cell Press
Year: 2019

description: We present a systematic analysis of the effects of synchronizing a large-scale, deeply characterized, multi-omic dataset to the current human reference genome, using updated software, pipelines, and annotations. For each of 5 molecular data platforms in The Cancer Genome Atlas (TCGA)—mRNA and miRNA expression, single nucleotide variants, DNA methylation and copy number alterations—comprehensive sample, gene, and probe-level studies were performed, towards quantifying the degree of similarity between the ‘legacy’ GRCh37 (hg19) TCGA data and its GRCh38 (hg38) version as ‘harmonized’ by the Genomic Data Commons. We offer gene lists to elucidate differences that remained after controlling for confounders, and strategies to mitigate their impact on biological interpretation. Our results demonstrate that the hg19 and hg38 TCGA datasets are very highly concordant, promote informed use of either legacy or harmonized omics data, and provide a rubric that encourages similar comparisons as new data emerge and reference data evolve. Gao et al. performed a systematic analysis of the effects of synchronizing the large-scale, widely used, multi-omic dataset of The Cancer Genome Atlas to the current human reference genome. For each of the five molecular data platforms assessed, they demonstrated a very high concordance between the ‘legacy’ GRCh37 (hg19) TCGA data and its GRCh38 (hg38) version as ‘harmonized’ by the Genomic Data Commons.
Production of silica-based ceramics sintered under nitrogen atmosphere from rice husk and sugarcane bagasse ash
Creators: name: Wiphawan KHOPTHONG
Publisher: name: Metallurgy and Materials Science Research Institute Chulalongkorn University
Year: 2020
Subjects: Nitride silica-based ceramics
Rice husk ash
Sugarcane bagasse ash
Nitridation

description: Journal of Metals Materials and Minerals, 30, 2, 76-82
Purcell effect in Hyperbolic Metamaterial Resonators
Creators: name: Slobozhanyuk, Alexey P.
name: Ginzburg, Pavel
name: Powell, David A.
name: Iorsh, Ivan
name: Shalin, Alexander S.
name: Segovia, Paulina
name: Krasavin, Alexey V.
name: Wurtz, Gregory A.
name: Podolskiy, Viktor A.
name: Belov, Pavel A.
name: Zayats, Anatoly V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The radiation dynamics of optical emitters can be manipulated by properly designed material structures providing high local density of photonic states, a phenomenon often referred to as the Purcell effect. Plasmonic nanorod metamaterials with hyperbolic dispersion of electromagnetic modes are believed to deliver a significant Purcell enhancement with both broadband and non-resonant nature. Here, we have investigated finite-size cavities formed by nanorod metamaterials and shown that the main mechanism of the Purcell effect in these hyperbolic resonators originates from the cavity hyperbolic modes, which in a microscopic description stem from the interacting cylindrical surface plasmon modes of the finite number of nanorods forming the cavity. It is found that emitters polarized perpendicular to the nanorods exhibit strong decay rate enhancement, which is predominantly influenced by the rod length. We demonstrate that this enhancement originates from Fabry-Perot modes of the metamaterial cavity. The Purcell factors, delivered by those cavity modes, reach several hundred, which is 4-5 times larger than those emerging at the epsilon near zero transition frequencies. The effect of enhancement is less pronounced for dipoles, polarized along the rods. Furthermore, it was shown that the Purcell factor delivered by Fabry-Perot modes follows the dimension parameters of the array, while the decay rate in the epsilon near-zero regime is almost insensitive to geometry. The presented analysis shows a possibility to engineer emitter properties in the structured metamaterials, addressing their microscopic structure.
A Note on the Importance of Weak Convergence Rates for SPDE Approximations in Multilevel Monte Carlo Schemes
Creators: name: Lang, Annika
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 65C05, 60H15

description: It is a well-known rule of thumb that approximations of stochastic partial differential equations have essentially twice the order of weak convergence compared to the corresponding order of strong convergence. This is already known for many approximations of stochastic (ordinary) differential equations while it is recent research for stochastic partial differential equations. In this note it is shown how the availability of weak convergence results influences the number of samples in multilevel Monte Carlo schemes and therefore reduces the computational complexity of these schemes for a given accuracy of the approximations.
description: 16 pages, 3 figures, updated to version published in the Proceedings of MCQMC14
Tribology, mechanical properties and coloration of a mica glass-ceramic
Creators: name: Sahadsaya PRASERTWONG
Publisher: name: Metallurgy and Materials Science Research Institute Chulalongkorn University
Year: 2020
Subjects: Mica glass-ceramic
Nanoindentation
Tribology
Wear
Coloration

description: Journal of Metals Materials and Minerals, 30, 2, 83-90
Exploring the social conditions which govern the processes of migration and non-migration of highly skilled Indian professionals to the UK
Creators: name: Sonawane, Sagar
Publisher: name: University of Leicester
Year: 2023
Subjects: Uncategorized

description: The aim of this research is to explore the social conditions that govern the processes of migration and non-migration of Indian doctors and IT professionals. The current study also explores both the push and pull factors, which are subjective and vary from person to person, depending on social institutional experience. The social conditions and processes are taken as subjective social realities which vary among highly skilled professionals. Data is collected from doctors and IT engineers working and living in India and the UK. The research takes a qualitative approach . Semi-structured interviews are conducted with 38 participants identified through social networks, personal contacts and a purposive snowball sampling technique. Thematic analysis is performed through coding and keywords using NVivo software. Current research has explored interaction between the institutional framework to explore the impact of families on individual decisions is significant, because of the collectivist nature of Indian society. The findings suggest that the migration and non-migration of highly skilled Indians is based on social conditions and constructed dynamic family factors such as marital status, gender, skill level, linking lives, family obligations, family size, whether the person is a single child, women’s role in the family, the decision-making power of the family and life experiences from childhood to maturity. These conditions vary across a lifespans and motivates to gain skills so that family members do not experience future social, organizational inequalities. The theoretical contribution is to merge institutional and social capital theory to develop a new conceptual framework which explicitly provides knowledge of the institutional and social capital role of social conditions. Institutional settings influence this social capital due to unequal access to institutional resources and job markets. Social capital theory explains the impact of the social conditions of the family as a whole on the migration process of highly skilled professional due to collectivism principal in Indian society.
Rapid clearance profile of plasma circulating tumor HPV type 16 DNA during chemoradiotherapy correlates with disease control in HPV-associated oropharyngeal cancer
Creators: name: Kumar, S.
name: Mendenhall, W.
name: Beaty, B.T.
name: Marron, D.
name: Grilley-Olson, J.E.
name: Amdur, R.
name: Hackman, T.
name: Zanation, A.
name: Hayes, D.N.
name: Sheets, N.
name: Parker, J.S.
name: Patel, S.
name: Dagan, R.
name: Chera, B.S.
name: Green, R.
name: Weissler, M.
name: Tan, X.M.
name: Blumberg, J.M.
name: Weiss, J.
name: Jefferys, S.
name: Gupta, G.P.
name: Goldman, E.C.
Publisher: name: American Association for Cancer Research Inc.
Year: 2019

description: Purpose: To identify a profile of circulating tumor human papilloma virus (HPV) DNA (ctHPVDNA) clearance kinetics that is associated with disease control after chemoradiotherapy (CRT) for HPV-associated oropharyngeal squamous cell carcinoma (OPSCC). Experimental Design: A multi-institutional prospective biomarker trial was conducted in 103 patients with (i) p16- positive OPSCC, (ii) M0 disease, and (iii) receipt of definitive CRT. Blood specimens were collected at baseline, weekly during CRT, and at follow-up visits. Optimized multianalyte digital PCR assays were used to quantify ctHPVDNA (types 16/18/31/33/35) in plasma. A control cohort of 55 healthy volunteers and 60 patients with non-HPV-associated malignancy was also analyzed. Results: Baseline plasma ctHPVDNA had high specificity (97%) and high sensitivity (89%) for detecting newly diagnosed HPV-associated OPSCC. Pretreatment ctHPV16DNA copy number correlated with disease burden, tumor HPV copy number, and HPV integration status. We define a ctHPV16DNA favorable clearance profile as having high baseline copy number (>200 copies/mL) and >95% clearance of ctHPV16DNA by day 28 of CRT. Nineteen of 67 evaluable patients had a ctHPV16DNA favorable clearance profile, and none had persistent or recurrent regional disease after CRT. In contrast, patients with adverse clinical risk factors (T4 or >10 pack years) and an unfavorable ctHPV16DNA clearance profile had a 35% actuarial rate of persistent or recurrent regional disease after CRT (P = 0.0049). Conclusions: A rapid clearance profile of ctHPVDNA may predict likelihood of disease control in patients with HPVassociated OPSCC patients treated with definitive CRT and may be useful in selecting patients for deintensified therapy.
Crystal Field Effect Induced Topological Crystalline Insulators In Monolayer IV-VI Semiconductors
Creators: name: Liu, Junwei
name: Qian, Xiaofeng
name: Fu, Liang
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Two-dimensional (2D) topological crystalline insulators (TCIs) were recently predicted in thin films of the SnTe class of IV-VI semiconductors, which can host metallic edge states protected by mirror symmetry. As thickness decreases, quantum confinement effect will increase and surpass the inverted gap below a critical thickness, turning TCIs into normal insulators. Surprisingly, based on first-principles calculations, here we demonstrate that (001) monolayers of rocksalt IV-VI semiconductors XY (X=Ge, Sn, Pb and Y= S, Se, Te) are 2D TCIs with the fundamental band gap as large as 260 meV in monolayer PbTe, providing a materials platform for realizing two-dimensional Dirac fermion systems with tunable band gap. This unexpected nontrivial topological phase stems from the strong {\it crystal field effect} in the monolayer, which lifts the degeneracy between $p_{x,y}$ and $p_z$ orbitals and leads to band inversion between cation $p_z$ and anion $p_{x,y}$ orbitals. This crystal field effect induced topological phase offers a new strategy to find and design other atomically thin 2D topological materials.
description: submitted in Jan. 2015 and published in Nano Lett
title: Elucidation of the role of methylarginine metabolism in regulation of nitric oxide production and inflammation
Creators: name: Alshuwayer, Noha Ali
Publisher: name: University of Glasgow
Year: 2024

description: Atherosclerosis is a major global health issue, and inflammation is important in its pathogenesis. Many atherosclerosis risk factors lead to reduced nitric oxide (NO) bioavailability. Asymmetric dimethylarginine (ADMA), an independent cardiovascular disease risk factor and NO synthase inhibitor, is metabolised by dimethylarginine dimethylaminohydrolase (DDAH). DDAH2 is the isoform present in the immune system. A deeper understanding of ADMA metabolism could help reveal new therapies for atherosclerosis. However, it is debated if DDAH2 hydrolyses ADMA. There is evidence that DDAH2 has NO-independent cellular functions, and research in our group showed that DDAH2 regulates macrophage functions.

This thesis initially aimed to investigate the role of DDAH2 in regulating inflammation in atherosclerosis models. However, this was derailed by limitations imposed by the Covid-19 pandemic. Therefore, models of inflammation were used. Genes and mechanisms associated with inflammation and atherosclerosis were investigated. 

RAW 264.7 murine macrophage cell line and bone marrow-derived macrophages (BMDM) were validated for suitability to study the DDAH-ADMA-NOS pathway. To better understand the functions of DDAH2, a macrophage-specific Ddah2 null mouse model was re-derived and validated. RNA sequencing data previously generated by our group from peritoneal macrophages of the same model was re-analysed and revealed almost 5,000 genes to be DDAH-dependent and required for normal immune response. More than 200 Reactome pathways appeared enriched, with apoptosis being the most enriched. The in silico data was validated in vitro in DDAH2-knockout peritoneal macrophages from the macrophage-specific Ddah2 null mouse model. Inferred hypotheses were investigated in DDAH2-Knockout BMDMs from the macrophage-specific Ddah2 null mouse model with confirmatory studies on C57BL/6J BMDMs using ADMA.

The in vitro analysis in the BMDMs showed no conclusive evidence supporting the in silico data that DDAH2 regulates the investigated genes (except Il17a), nor did ADMA alter the gene response to LPS. Il17a was shown by the in silico analysis to be regulated by DDAH2 and was validated in vitro in peritoneal macrophages by both RT-qPCR and ELISA. Given the significant role of IL17A in inflammation and its existing use in treating systemic inflammatory conditions such as psoriasis, this thesis proposes DDAH2 as a potential therapeutic target for inflammatory diseases in general and atherosclerosis in particular.
The prognostic significance of low-frequency somatic mutations in metastatic cutaneous melanoma
Creators: name: Hayes, D.N.
name: Hugo, W.
name: Johansson, P.A.
name: Salazar, A.H.
name: Lo, R.S.
name: Thompson, J.F.
name: Little, P.
name: Collichio, F.A.
name: Googe, P.B.
name: Lee, C.B.
name: Hayward, M.C.
name: Ezzell, A.J.
name: Bouchard, D.M.
name: Johnson, D.B.
name: Earp, H.S.
name: Thomas, N.E.
name: Wilmott, J.S.
name: Papakonstantinou, M.P.
name: Frank, J.S.
name: Hoadley, K.A.
name: Moschos, S.J.
name: Soloway, M.G.
name: Parker, J.S.
name: Jo, H.
name: Sharpless, N.E.
name: Pegna, G.J.
name: Jefferys, S.R.
name: Ivanova, A.
name: Scolyer, R.A.
name: Waddell, N.
name: Ollila, D.W.
name: Hayward, N.K.
name: Quek, C.
name: Hoyle, A.P.
name: Mann, G.J.
name: Zhao, X.
name: Marron, D.L.
Publisher: name: Frontiers Media S.A.
Year: 2019

description: Background: Little is known about the prognostic significance of somatically mutated genes in metastatic melanoma (MM). We have employed a combined clinical and bioinformatics approach on tumor samples from cutaneous melanoma (SKCM) as part of The Cancer Genome Atlas project (TCGA) to identify mutated genes with potential clinical relevance. Methods: After limiting our DNA sequencing analysis to MM samples (n = 356) and to the CANCER CENSUS gene list, we filtered out mutations with low functional significance (snpEFF). We performed Cox analysis on 53 genes that were mutated in ≥3% of samples, and had ≥50% difference in incidence of mutations in deceased subjects versus alive subjects. Results: Four genes were potentially prognostic [RAC1, FGFR1, CARD11, CIITA; false discovery rate (FDR) < 0.2]. We identified 18 additional genes (e.g., SPEN, PDGFRB, GNAS, MAP2K1, EGFR, TSC2) that were less likely to have prognostic value (FDR < 0.4). Most somatic mutations in these 22 genes were infrequent (< 10%), associated with high somatic mutation burden, and were evenly distributed across all exons, except for RAC1 and MAP2K1. Mutations in only 9 of these 22 genes were also identified by RNA sequencing in >75% of the samples that exhibited corresponding DNA mutations. The low frequency, UV signature type and RNA expression of the 22 genes in MM samples were confirmed in a separate multi-institution validation cohort (n = 413). An underpowered analysis within a subset of this validation cohort with available patient follow-up (n = 224) showed that somatic mutations in SPEN and RAC1 reached borderline prognostic significance [log-rank favorable (p = 0.09) and adverse (p = 0.07), respectively]. Somatic mutations in SPEN, and to a lesser extent RAC1, were not associated with definite gene copy number or RNA expression alterations. High (>2+) nuclear plus cytoplasmic expression intensity for SPEN was associated with longer melanoma-specific overall survival (OS) compared to lower (≤ 2+) nuclear intensity (p = 0.048). We conclude that expressed somatic mutations in infrequently mutated genes beyond the well-characterized ones (e.g., BRAF, RAS, CDKN2A, PTEN, TP53), such as RAC1 and SPEN, may have prognostic significance in MM.
Is order-by-disorder present or absent in a highly frustrated region of the spin-1/2 Ising-Heisenberg model on triangulated Husimi lattices?
Creators: name: Strecka, J.
name: Ekiz, C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: The geometrically frustrated spin-1/2 Ising-Heisenberg model on triangulated Husimi lattices is exactly solved by combining the generalized star-triangle transformation with the method of exact recursion relations. The ground-state and finite-temperature phase diagrams are rigorously calculated along with both sublattice magnetizations of the Ising and Heisenberg spins. It is evidenced that the Ising-Heisenberg model on triangulated Husimi lattices with two or three inter-connected triangles-in-triangles units displays in a highly frustrated region a quantum disorder irrespective of temperature, whereas the same model on triangulated Husimi lattices with a greater connectivity of triangles-in-triangles units exhibits at low enough temperatures an outstanding quantum order due to the order-by-disorder mechanism. The quantum reduction of both sublattice magnetizations in the peculiar quantum ordered state gradually diminishes with increasing the coordination number of underlying Husimi lattice.
description: 9 pages, 4 figures
The impact of COVID-19 and associated shocks on agri-food SMEs along the poultry and fish value chains in Oyo State
Creators: name: Abagyeh-Igbudu, Iveren
name: Tasie, Saweda
name: Belton, Ben
name: Tasie, Oyinkan
name: Reardon, Thomas
name: Wellington, Osawe
name: Abagyeh-Igbudu, Iveren
name: Tasie, Saweda
name: Belton, Ben
name: Tasie, Oyinkan
name: Reardon, Thomas
name: Wellington, Osawe
Publisher: name: Unknown
Year: 2021
Subjects: subject: Agricultural and Food Policy
subject: Nigeria
subject: Agriculture
subject: Policy
subject: Economics

description: This policy research note summarizes the key findings from a study on the impact of COVID-19 and associated policies on SMEs along the poultry and fish value chains in Oyo State.
Prognostic value of B cells in cutaneous melanoma
Creators: name: Chai, S.
name: Selitsky, S.R.
name: Dittmer, D.P.
name: Moschos, S.J.
name: Hoadley, K.A.
name: Smith, C.C.
name: Vincent, B.G.
name: Parker, J.S.
name: Mose, L.E.
Publisher: name: BioMed Central Ltd.
Year: 2019

description: Background: Measures of the adaptive immune response have prognostic and predictive associations in melanoma and other cancer types. Specifically, intratumoral T cell density and function have considerable prognostic and predictive value in skin cutaneous melanoma (SKCM). Less is known about the significance of tumor-infiltrating B cells in SKCM. Our goal was to understand the prognostic and predictive value of B cell phenotypic subsets in SKCM using RNA sequencing. Methods: We used our previously published algorithm, V'DJer, to assemble B cell receptor (BCR) repertoires and estimate diversity from short-read RNA sequencing (RNA-seq). We applied machine learning-based cellular phenotype classifiers to measure relative similarity of bulk tumor sample gene expression profiles and different B cell phenotypes. We assessed these aspects of B cell biology in 473 SKCM from the Cancer Genome Atlas Project (TCGA) as well as in RNA-seq data corresponding to tumor samples procured from patients who received CTLA-4 and PD-1 inhibitors for metastatic SKCM. Results: We found that the BCR repertoire was associated with different clinical factors, such as tumor tissue site and sex. However, increased clonality of the BCR repertoire was favorably prognostic in SKCM and was prognostic even after first conditioning on various clinical factors. Mutation burden was not correlated with any BCR measurement, and no specific mutation had an altered BCR repertoire. Lack of an assembled BCR in pre-treatment tumor tissues was associated with a lack of anti-tumor response to a CTLA-4 inhibitor in metastatic SKCM. Conclusions: These findings suggest an important prognostic and predictive role for B cell characteristics in SKCM. This has implications for melanoma immunobiology and potential development of immunogenomics features to predict survival and response to immunotherapy.
Endothelial miR-30c suppresses tumor growth via inhibition of TGF-β–induced Serpine1
Creators: name: Anderson, D.G.
name: Turner, S.D.
name: Kim, D.J.
name: Khan, O.F.
name: Tsai, Y.S.
name: Xiao, L.
name: Pecot, C.V.
name: Tatsumi, K.
name: Parker, J.S.
name: Mackman, N.
name: Dudley, A.C.
name: Azam, S.H.
name: Kowalski, P.S.
name: Wolberg, A.S.
name: McCann, J.V.
Publisher: name: American Society for Clinical Investigation
Year: 2019

description: In tumors, extravascular fibrin forms provisional scaffolds for endothelial cell (EC) growth and motility during angiogenesis. We report that fibrin-mediated angiogenesis was inhibited and tumor growth delayed following postnatal deletion of Tgfbr2 in the endothelium of Cdh5-CreERT2 Tgfbr2fl/fl mice (Tgfbr2iECKOmice). ECs from Tgfbr2iECKO mice failed to upregulate the fibrinolysis inhibitor plasminogen activator inhibitor 1 (Serpine1, also known as PAI-1), due in part to uncoupled TGF-β–mediated suppression of miR-30c. Bypassing TGF-β signaling with vascular tropic nanoparticles that deliver miR-30c antagomiRs promoted PAI-1–dependent tumor growth and increased fibrin abundance, whereas miR-30c mimics inhibited tumor growth and promoted vascular-directed fibrinolysis in vivo. Using single-cell RNA-Seq and a NanoString miRNA array, we also found that subtypes of ECs in tumors showed spectrums of Serpine1 and miR-30c expression levels, suggesting functional diversity in ECs at the level of individual cells; indeed, fresh EC isolates from lung and mammary tumor models had differential abilities to degrade fibrin and launch new vessel sprouts, a finding that was linked to their inverse expression patterns of miR-30c and Serpine1 (i.e., miR-30chi Serpine1lo ECs were poorly angiogenic and miR-30clo Serpine1hi ECs were highly angiogenic). Thus, by balancing Serpine1 expression in ECs downstream of TGF-β, miR-30c functions as a tumor suppressor in the tumor microenvironment through its ability to promote fibrin degradation and inhibit blood vessel formation.
Green-based corrosion protection for mild steel in 3.5% NaCl and distilled water medias: Jatropha curcas and Roselle extracts
Creators: name: AFANDI, Muhammad A.
Publisher: name: Metallurgy and Materials Science Research Institute Chulalongkorn University
Year: 2020
Subjects: Green inhibitor
Jatropha curcas
Roselle
Corrosion
Mild steel

description: Journal of Metals Materials and Minerals, 30, 2, 91-104