cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Response from Demetrio Jimenez to John Brenneman, Temporary Building, Fort Sam Houston, Texas
Creators: name: Jimenez, Demetrio
Publisher: name: Texas Historical Commission
Year: 1994
Subjects: subject: JBSA-Sam Houston
valueUri: https://core.tdar.org/browse/geographic-keyword/82532/jbsa-sam-houston
subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: The Texas Historical Commission has received and reviewed information submitted by Fort Sam Houston regarding the proposed installation of a relocatable building. The Commission concurs with Fort Sam Houston's determination of "no effect" in accordance with Section 106 guidelines. Copied to this correspondence is Mike Hilger, Preservation Architect, Fort Sam Houston.
Structure and immune recognition of trimeric pre-fusion HIV-1 Env
Creators: name: Munro, James B.
name: Morris, Lynn
name: Zhou, Tongqing
name: Bailer, Robert T.
name: Druz, Aliaksandr
name: Connors, Mark
name: Acharya, Priyamvada
name: Tumba, Nancy
name: Gorman, Jason
name: Haynes, Barton F.
name: Joyce, M. Gordon
name: Yang, Yongping
name: Kwong, Peter D.
name: Louder, Mark K.
name: Stewart-Jones, Guillaume B. E.
name: Georgiev, Ivelin S.
name: Zhang, Baoshan
name: Soto, Cinque
name: Chuang, Gwo-Yu
name: Pancera, Marie
name: Mascola, John R.
name: Stuckey, Jonathan
name: Blanchard, Scott C.
name: Cohen, Myron S.
name: Ofek, Gilad
name: Mothes, Walther
name: Huang, Jinghe
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The HIV-1-envelope (Env) spike, comprising three gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by rearranging from a mature unliganded state, through receptor-bound intermediates, to a postfusion state. As the sole viral antigen on the HIV-1-virion surface, Env is both the target of neutralizing antibodies and a focus of vaccine efforts. Here we report the structure at 3.5-Å resolution for an HIV-1-Env trimer captured in a mature closed state by antibodies PGT122 and 35O22. This structure reveals the prefusion conformation of gp41, indicates rearrangements needed for fusion activation, and defines parameters of immune evasion and immune recognition. Prefusion gp41 encircles N- and C-terminal strands of gp120 with four helices that form a membrane-proximal collar, fastened by insertion of a fusion peptide-proximal methionine into a gp41-tryptophan clasp. Spike rearrangements required for entry likely involve opening the clasp and expelling the termini. N-linked glycosylation and sequence-variable regions cover the prefusion closed spike: we used chronic cohorts to map the prevalence and location of effective HIV-1-neutralizing responses, which were distinguished by their recognition of N-linked glycan and tolerance for epitope-sequence variation.
A Study of Factors Effecting on the Performance Report According to the Performance Agreement, Faculty of Informatics, Mahasarakham University
Creators: name: Jarunee Oupkaew
Publisher: name: DR.KEN Institute of Academic Development and Promotion.
Year: 2023
Subjects: Government Performance
Relationship
Operating Factors

description: Interdisciplinary Academic and Research Journal, 3, 3, 753-766
Letter from Brian Miller to Curtis Tunnell, Half Court Basketball Courts for Circle Housing, Randolph Air Force Base, Texas
Creators: name: Miller, Brian L.
Publisher: name: Randolph Air Force Base
Year: 1997
Subjects: subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Randolph Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/78971/randolph-air-force-base
subject: Non-Domestic Structures
valueUri: https://core.tdar.org/browse/site-type/309/non-domestic-structures
subject: Ball Court
valueUri: https://core.tdar.org/browse/site-type/310/ball-court
subject: Basketball Court
valueUri: https://core.tdar.org/browse/other-keyword/153799/basketball-court
subject: Circle Housing
valueUri: https://core.tdar.org/browse/other-keyword/158197/circle-housing
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: Randolph Air Force Base developed an undertaking to construct, within the Randolph Field Historic District; specifically, in the circle housing area, two half court basketball courts. This letter gives details concerning the Section 106 coordination of the project.
AFRICAN AMERICAN HETEROSEXUAL COUPLES COPING WITH RACIAL DISCRIMINATION
Creators: name: Kartashev, Maria
Publisher: name: Digital Repository at the University of Maryland
Year: 2022
Subjects: subject: Therapy

description: This qualitative study investigated how African American heterosexual couples’ relationship are affected by racial discrimination and how they cope with stress from racial discrimination (including communicating their own and responding to each other’s stress). The data were analyzed using thematic analysis, and themes were organized based on the areas of inquiry. Themes related to the impact of racial discrimination on the couple relationship included “my partner’s experiences of racial discrimination also affect me,” and “couples feel connected through the similarities in the experience of discrimination.” Themes regarding coping as a couple included “talking about racial discrimination with your partner helps,” “agree to disagree,” “joking together to show solidarity,” and “complementary gender responses to racial discrimination.” Themes were discussed using the systemic-transactional model of dyadic coping (Bodenmann, 1995, 2005). Though further research is needed to understand the impact of racial discrimination on African American couples and their coping, the current study suggests that couples cope with racial discrimination dyadically. This coping is diverse and sometimes gendered. Additionally, creating a safe space of compassion, despite differences in perceptions of racial discrimination, helps couples feel bonded by mutual trust, intimacy, and connectedness. Finally, limitations, clinical and research implications, and issues of reflexivity were discussed.
Notes from Scott Shepherd, Building 156 Foreclosure, Randolph Air Force Base, Texas
Creators: name: Shepherd, Scott B.
Publisher: name: Randolph Air Force Base
Year: 1993
Subjects: subject: Randolph Field Historic Landmark District
valueUri: https://core.tdar.org/browse/geographic-keyword/83364/randolph-field-historic-landmark-district
subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Randolph Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/78971/randolph-air-force-base
subject: World War II
valueUri: https://core.tdar.org/browse/temporal-keyword/3992/world-war-ii
subject: WWII
valueUri: https://core.tdar.org/browse/temporal-keyword/5196/wwii
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: Non-Domestic Structures
valueUri: https://core.tdar.org/browse/site-type/309/non-domestic-structures
subject: Building 156
valueUri: https://core.tdar.org/browse/other-keyword/146304/building-156
subject: Temporary Building
valueUri: https://core.tdar.org/browse/other-keyword/158926/temporary-building
subject: World War II
valueUri: https://core.tdar.org/browse/other-keyword/124433/world-war-ii
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: A few emails written as notes by Scott Shepherd detailing conversations and drafting for formal letters concerning the proposed undertakings for Building 156 at Randolph Air Force Base, Texas. This letter is part of a large packet of correspondence and associated documents concerning a complex proposal of undertakings for World War II temporary buildings located on Randolph Air Force Base, Texas. Many of the documents are drafts and letters from internal circulation within Randolph Air Force Base.
Letter from Joseph Logan to Curtis Tunnell, Rehabilitation of Building 671, Randolph Air Force Base, Texas
Creators: name: Logan, Joseph M.
Publisher: name: Department of the Air Force, Randolph Air Force Base
Year: 1992
Subjects: subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Randolph Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/78971/randolph-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: Non-Domestic Structures
valueUri: https://core.tdar.org/browse/site-type/309/non-domestic-structures
subject: Building 671
valueUri: https://core.tdar.org/browse/other-keyword/146452/building-671
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: A letter discussing the initial work request submitted for the proposed undertaking to rehabilitate the basement of Building 671, Randolph Air Force Base, Texas. This correspondence is part of a group of letters and supporting documentation for the proposed undertaking to rehabilitate the interior of the first floor and basement at Building 671, Randolph Air Force Base, Texas. Summary documentation in the attachments include location maps, historic data, photographs, drawings, and the undertaking description and assessment.
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway
Creators: name: Mai, Junhua
name: Tam, Wai Leong
name: Liu, X. Shirley
name: Shin, Sandra J.
name: Brown, Myles
name: Chang, Jenny C.
name: Iliopoulos, Dimitrios
name: Chen, Xi
name: Tan, Chen
name: Hu, Dorothy Z.
name: Adoro, Stanley
name: Tang, Qianzi
name: Chen, Yiwen
name: Ni, Min
name: Song, Minkyung
name: Shen, Haifa
name: Ferrari, Mauro
name: Glimcher, Laurie H.
name: Hu, Bella
name: Landis, Melissa D.
name: Lim, Elgene
name: Hatziapostolou, Maria
name: Greenblatt, Matthew B.
name: Zhang, Qing
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Cancer cells induce a set of adaptive response pathways to survive in the face of stressors due to inadequate vascularization1. One such adaptive pathway is the unfolded protein (UPR) or endoplasmic reticulum (ER) stress response mediated in part by the ER-localized transmembrane sensor IRE12 and its substrate XBP13. Previous studies report UPR activation in various human tumors4-6, but XBP1's role in cancer progression in mammary epithelial cells is largely unknown. Triple negative breast cancer (TNBC), a form of breast cancer in which tumor cells do not express the genes for estrogen receptor, progesterone receptor, and Her2/neu, is a highly aggressive malignancy with limited treatment options7, 8. Here, we report that XBP1 is activated in TNBC and plays a pivotal role in the tumorigenicity and progression of this human breast cancer subtype. In breast cancer cell line models, depletion of XBP1 inhibited tumor growth and tumor relapse and reduced the CD44high/CD24low population. Hypoxia-inducing factor (HIF)1α is known to be hyperactivated in TNBCs 9, 10. Genome-wide mapping of the XBP1 transcriptional regulatory network revealed that XBP1 drives TNBC tumorigenicity by assembling a transcriptional complex with HIF1α that regulates the expression of HIF1α targets via the recruitment of RNA polymerase II. Analysis of independent cohorts of patients with TNBC revealed a specific XBP1 gene expression signature that was highly correlated with HIF1α and hypoxia-driven signatures and that strongly associated with poor prognosis. Our findings reveal a key function for the XBP1 branch of the UPR in TNBC and imply that targeting this pathway may offer alternative treatment strategies for this aggressive subtype of breast cancer.
Causality Constraints on Corrections to the Graviton Three-Point Coupling
Creators: name: Camanho, Xian O.
name: Edelstein, Jose D.
name: Maldacena, Juan
name: Zhiboedov, Alexander
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We consider higher derivative corrections to the graviton three-point coupling within a weakly coupled theory of gravity. Lorentz invariance allows further structures beyond the one present in the Einstein theory. We argue that these are constrained by causality. We devise a thought experiment involving a high energy scattering process which leads to causality violation if the graviton three-point vertex contains the additional structures. This violation cannot be fixed by adding conventional particles with spins $J \leq 2$. But, it can be fixed by adding an infinite tower of extra massive particles with higher spins, $J > 2$. In AdS theories this implies a constraint on the conformal anomaly coefficients $\left|{a - c \over c} \right| \lesssim {1 \over Δ_{gap}^2}$ in terms of $Δ_{gap}$, the dimension of the lightest single particle operator with spin $J > 2$. For inflation, or de Sitter-like solutions, it indicates the existence of massive higher spin particles if the gravity wave non-gaussianity deviates significantly from the one computed in the Einstein theory.
description: 50+22 pages, 13 figures
A global perspective on the influence of environmental exposures on the nervous system
Creators: name: Mwanza, Jean-Claude
name: Maestre, Gladys
name: Oriá, Reinaldo B.
name: Tshala-Katumbay, Desire
name: Rohlman, Diane S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Economic and social transitions in the era of globalization warrant a fresh look at the neurological risks associated with environmental change. These are driven by industrial expansion, transfer and mobility of goods, climate change and population growth. In these contexts, risk of both infectious and non-infectious diseases are shared across geographical boundaries. In low- and middle-income countries, the risk of environmentally mediated brain disease is augmented several-fold by lack of infrastructure, poor health and safety regulations, and limited measures for environmental protection. Neurological disorders may occur as a result of direct exposure to chemical and/or non-chemical stressors such as ultrafine particulate matters. Individual susceptibilities to exposure-related diseases are modified by genetic, epigenetic and metagenomic factors. The existence of several uniquely exposed populations, including those in the areas surrounding the Niger Delta or north western Amazon oil operations; those working in poorly regulated environments, such as artisanal mining industries; or those, mostly in sub-Saharan Africa, relying on cassava as a staple food, offers invaluable opportunities to advance the current understanding of brain responses to environmental challenges. Increased awareness of the brain disorders that are prevalent in low- and middle-income countries and investments in capacity for further environmental health-related research are positive steps towards improving human health.
OAHP Inventory, Gates at the Quadrangle Entrance, Fort Sam Houston, Texas
Creators: name: Walter, Chelsea
Publisher: name: Office of Archaeology and Historic Preservation
Year: 1980
Subjects: subject: Fort Sam Houston
valueUri: https://core.tdar.org/browse/geographic-keyword/83681/fort-sam-houston
subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Non-Domestic Structures
valueUri: https://core.tdar.org/browse/site-type/309/non-domestic-structures
subject: Gates
valueUri: https://core.tdar.org/browse/other-keyword/114674/gates
subject: OAHP
valueUri: https://core.tdar.org/browse/other-keyword/138292/oahp
subject: Quadrangle
valueUri: https://core.tdar.org/browse/other-keyword/146777/quadrangle
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Architectural Survey
valueUri: https://core.tdar.org/browse/investigation-type/2/architectural-survey
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: An inventory form by the Office of Archaeology and Historic Preservation of historic gates at Fort Sam Houston, Texas. The gates are located at the Quadrangle entrance on Grayson Street. Included in the inventory are black and white photographs taken in 1980 of the gates.
A global reference for human genetic variation
Creators: name: Guo, Xiaosen
name: Tang, Meifang
name: Lan, Tianming
name: Li, Jingxiang
name: Fang, Xiaodong
name: Lee, Sandra
name: Li, Guoqing
name: Chang, Yuqi
name: Lu, Yao
name: Korchina, Viktoriya
name: Feng, Qiang
name: Ma, Xuedi
name: Wang, Guangbiao
name: Gibbs, Richard A.
name: Doddapaneni, Harsha
name: Jiang, Hui
name: Liu, Xiao
name: Kovar, Christie
name: Zhu, Yiming
name: Jian, Min
name: Li, Yingrui
name: Boerwinkle, Eric
name: Muzny, Donna
name: Wang, Bo
name: Reid, Jeffrey G.
name: Xu, Xun
name: Wang, Jun
name: Jin, Xin
name: Wu, Honglong
name: Han, Yi
name: Wu, Renhua
name: Liu, Shengmao
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The 1000 Genomes Project set out to provide a comprehensive description of common human genetic variation by applying whole-genome sequencing to a diverse set of individuals from multiple populations. Here we report completion of the project, having reconstructed the genomes of 2,504 individuals from 26 populations using a combination of low-coverage whole-genome sequencing, deep exome sequencing, and dense microarray genotyping. We characterized a broad spectrum of genetic variation, in total over 88 million variants (84.7 million single nucleotide polymorphisms (SNPs), 3.6 million short insertions/deletions (indels), and 60,000 structural variants), all phased onto high-quality haplotypes. This resource includes >99% of SNP variants with a frequency of >1% for a variety of ancestries. We describe the distribution of genetic variation across the global sample, and discuss the implications for common disease studies.
Statement of Work, Construct Furnishings Management Warehouse, Randolph Air Force Base, Texas
Creators: name: Graham, Joshua
Publisher: name: Randolph Air Force Base
Year: 2011
Subjects: subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Randolph Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/78971/randolph-air-force-base
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Non-Domestic Structures
valueUri: https://core.tdar.org/browse/site-type/309/non-domestic-structures
subject: Furnishings Management Warehouse
valueUri: https://core.tdar.org/browse/other-keyword/158210/furnishings-management-warehouse
subject: Warehouse
valueUri: https://core.tdar.org/browse/other-keyword/134185/warehouse
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management
subject: Research Design / Data Recovery Plan
valueUri: https://core.tdar.org/browse/investigation-type/9/research-design-data-recovery-plan

description: This statement of work details the specifications for the design and construction of a furnishings management warehouse on Randolph Air Force Base. The specs include general requirements, scope of work, design submittal schedule, submittals, demolition, construction, specifications, and additional attachments. The Project Manager for this scope of work is Joshua Graham, EIT.
(:unas) unassigned
Creators: name: (:Unkn) Unknown
Publisher: name: Universita' degli Studi di Salerno
Year: 2024

description: Il saggio - frutto delle riflessioni nate nei lavori conclusivi del Convegno ADI «Per un nuovo ca none del Novecento letterario italiano. Le poe tesse» a cura del gruppo di lavoro “Studi delle donne nella letteratura italiana” - si interroga sulla necessità ed urgenza di individuare una me todologia di studi, varia ma comune agli studiosi e alle studiose, per affrontare la questione del ca none delle donne della poesia italiana del Nove cento. Un canone che nel presente lavoro non viene considerato parallelo o oppositivo rispetto ai canoni della tradizione poetica italiana del se colo scorso. Piuttosto, ricostruendo in dettaglio e ragionando sulla presenza silenziosa delle voci delle donne nelle principali antologie e nei catalo ghi editoriali del Novecento, un’idea di canone si lente, ma esistente in termini di opere e di testi. Eppure ancora difficile da codificare, in ragione della mancanza di una organizzazione degli studi critici.
description: The essay - the result of the reflections born in the final works of the ADI Conference «For a new canon of twentieth-century Italian literature. The poetesses» by the working group "Women's studies in Italian literature" - questions the need and urgency of identifying a methodology of studies, varied but common to scholars, to address the question of the canon of women in poetry Italian of the twentieth century. A canon that in this work is not considered parallel or oppositional to the canons of the Italian poetic tradition of the last century. Rather, reconstructing in detail and reasoning on the silent presence of women's voices in the main anthologies and editorial catalogs of the twentieth century, an idea of a silent canon, but existing in terms of works and texts. Yet still difficult to codify, due to the lack of organization of critical studies.
A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis
Creators: name: Perou, Charles M.
name: Gutiérrez-Ángel, Sara
name: Hartl, Christina A.
name: Gable, Annika L.
name: Kim, Sun Y.
name: Hannon, Gregory J.
name: Smith, Andrew D.
name: Williams, Alissa M.
name: Soto, Mar
name: Dickopf, Steffen
name: Harrell, J. Chuck
name: Wilkinson, John E.
name: Knott, Simon R. V.
name: Maceli, Ashley R.
name: Wagenblast, Elvin
name: Erard, Nicolas
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Cancer metastasis requires that primary tumour cells evolve the capacity to intravasate into the lymphatic system or vasculature, and extravasate into and colonize secondary sites1. Others have demonstrated that individual cells within complex populations show heterogeneity in their capacity to form secondary lesions2–5. Here we develop a polyclonal mouse model of breast tumour heterogeneity, and show that distinct clones within a mixed population display specialization, for example, dominating the primary tumour, contributing to metastatic populations, or showing tropism for entering the lymphatic or vasculature systems. We correlate these stable properties to distinct gene expression profiles. Those clones that efficiently enter the vasculature express two secreted proteins, Serpine2 and Slpi, which were necessary and sufficient to program these cells for vascular mimicry. Our data indicate that these proteins not only drive the formation of extra-vascular networks but also ensure their perfusion by acting as anticoagulants. We propose that vascular mimicry drives the ability of some breast tumour cells to contribute to distant metastases while simultaneously satisfying a critical need of the primary tumour to be fed by the vasculature. Enforced expression of SERPINE2 and SLPI in human breast cancer cell lines also programmed them for vascular mimicry, and SERPINE2 and SLPI were overexpressed preferentially in human patients that had lung-metastatic relapse. Thus, these two secreted proteins, and the phenotype they promote, may be broadly relevant as drivers of metastatic progression in human cancer.
LPP INDEXES BASELINE AND TREATMENT-RELATED CHANGES IN ANXIETY SENSITIVITY
Creators: name: Butler, Devin
Publisher: name: Digital Repository at the University of Maryland
Year: 2022
Subjects: subject: Psychology
subject: FOS: Psychology
subject: anxiety sensitivity
subject: CAST
subject: lpp
subject: psychopathology
subject: treatment

description: Anxiety sensitivity (AS) refers to an individual’s tendency to be fearful of anxiety-related bodily sensations (the symptoms that accompany feelings of anxiety)(Reiss et al., 1986). These symptoms can be cognitive (i.e., fear of losing control of mental processes), physical (i.e., fear of catastrophic physiological outcomes such as heart attack or stroke), or social (i.e., concern about negative social judgment and subsequent observable symptoms of anxiety). AS is a well-understood risk factor for Internalizing psychopathology (INT). Cognitive Anxiety Sensitivity Treatment (CAST) (Schmidt et al., 2014) is a technology-based intervention shown to be efficacious in reducing AS, as well as INT. CAST is a fully-computerized brief intervention with two core components: psychoeducation and interoceptive exposure (Craske et al., 1997). In recent work by Schmidt, nontreatment seeking participants with elevated AS cognitive concerns participated in one session of CAST, which produced significant reductions in AS at posttreatment, relative to controls (d=0.57). The primary purpose of this study is to assess the late positive potential (LPP) event-related potential (ERP) component as an index of baseline AS, as well as treatment-related change in AS in response to CAST. In this study 263 participants (with complete EEG data at 1-month follow-up) received either an anxiety reduction intervention (Anxiety; CAST + cognitive bias modification interpretation [CBM-I] with an anxiety focus; N = 65), a mood intervention (Mood; mood psychoeducation + CBM-I with a mood focus; N = 66), or combined ANX and MOOD interventions (Combined; N = 68), as well a repeated contact control group (RCC; N= 64). Prior to the intervention, baseline LPP was measured via exposure to unpleasant, and baseline AS recorded using the ASI-3. Increased LPP amplitude was associated with higher baseline AS (r=.184, p <.001). We found that the LPP was sensitive to treatment effects in that at month 1, as across treatment groups, baseline LPP amplitude was associated with change in AS from baseline to month 1, with higher amplitude associating with greater reductions in AS (r = -.247, p < .001). In this study, there were no differences between treatment groups in this relationship between amplitude and treatment change, and there were no significant effects of the decrease task instruction on amplitude. These findings could be indicative of a larger pattern to be assessed in future work, or could be a product of low power. Overall, this work’s findings have potential to demonstrate the efficacy of CAST in reducing AS, and given both CAST’s and AS’s implications in psychopathology measures such as internalizing, we can integrate transdiagnostic approaches and develop novel treatment targets for populations in need.
Loss-resistant unambiguous phase measurement
Creators: name: Dinani, Hossein T.
name: Berry, Dominic W.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Entangled multi-photon states have the potential to provide improved measurement accuracy, but are sensitive to photon loss. It is possible to calculate ideal loss-resistant states that maximize the Fisher information, but it is unclear how these could be experimentally generated. Here we propose a set of states that can be obtained by processing the output from parametric down-conversion. Although these states are not optimal, they provide performance very close to that of optimal states for a range of parameters. Moreover, we show how to use sequences of such states in order to obtain an unambiguous phase measurement that beats the standard quantum limit. We consider the optimization of parameters in order to minimize the final phase variance, and find that the optimum parameters are different from those that maximize the Fisher information.
description: 8 pages, 7 figures, comments are welcome
Temporal Quantum-State Tomography of Narrowband Biphotons
Creators: name: Chen, Peng
name: Shu, Chi
name: Guo, Xianxin
name: Loy, M. M. T.
name: Du, Shengwang
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We describe and demonstrate a quantum state tomography for measuring the complex temporal waveform of narrowband biphotons. Through six sets of two-photon interference measurements projected in different polarization subspaces, we can construct the time-frequency entangled two-photon joint amplitude and phase functions in continuous-variable time domain. For the first time, we apply this technique to experimentally determine the temporal quantum states of narrowband biphotons generated from spontaneous four-wave mixing in cold atoms, and fully confirm the theoretical predictions.
description: 5 pages, 5 figures
Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65
Creators: name: Koller, Beverly H.
name: Jiang, Alice
name: Jin, Jian
name: Wang, Sheng
name: Kroeze, Wesley K.
name: Roth, Bryan L.
name: Huang, Xi-Ping
name: Chen, Xin
name: Zhu, Hu
name: Penn, Raymond B.
name: Shoichet, Brian K.
name: Karpiak, Joel
name: Farrell, Martilias S.
name: Deshpande, Deepak A.
name: Kenakin, Terry
name: Moy, Sheryl S.
name: Saddoris, Kara A.
name: Mangano, Thomas J.
name: Nikolova, Viktoriya D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: At least 120 non-olfactory G protein-coupled receptors in the human genome are ”orphans” for which endogenous ligands are unknown, and many have no selective ligands, hindering elucidation of their biological functions and clinical relevance. Among these is GPR68, a proton receptor that lacks small molecule modulators for probing its biology. Yeast-based screens against GPR68 identified the benzodiazepine drug lorazepam as a non-selective GPR68 positive allosteric modulator. Over 3000 GPR68 homology models were refined to recognize lorazepam in a putative allosteric site. Docking 3.1 million molecules predicted new GPR68 modulators many of which were confirmed in functional assays. One potent GPR68 modulator—ogerin– suppressed recall in fear conditioning in wild-type, but not in GPR68 knockout mice. The same approach led to the discovery of allosteric agonists and negative allosteric modulators for GPR65. Combining physical and structure-based screening may be broadly useful for ligand discovery for understudied and orphan GPCRs.
3D simulation of complex shading affecting PV systems taking benefit from the power of graphics cards developed for the video game industry
Creators: name: Robledo, Jesus
name: Leloux, Jonathan
name: Lorenzo, Eduardo
Publisher: name: arXiv
Year: 2014
Subjects: subject: Other Computer Science (cs.OH)
subject: FOS: Computer and information sciences

description: Shading reduces the power output of a photovoltaic (PV) system. The design engineering of PV systems requires modeling and evaluating shading losses. Some PV systems are affected by complex shading scenes whose resulting PV energy losses are very difficult to evaluate with current modeling tools. Several specialized PV design and simulation software include the possibility to evaluate shading losses. They generally possess a Graphical User Interface (GUI) through which the user can draw a 3D shading scene, and then evaluate its corresponding PV energy losses. The complexity of the objects that these tools can handle is relatively limited. We have created a software solution, 3DPV, which allows evaluating the energy losses induced by complex 3D scenes on PV generators. The 3D objects can be imported from specialized 3D modeling software or from a 3D object library. The shadows cast by this 3D scene on the PV generator are then directly evaluated from the Graphics Processing Unit (GPU). Thanks to the recent development of GPUs for the video game industry, the shadows can be evaluated with a very high spatial resolution that reaches well beyond the PV cell level, in very short calculation times. A PV simulation model then translates the geometrical shading into PV energy output losses. 3DPV has been implemented using WebGL, which allows it to run directly from a Web browser, without requiring any local installation from the user. This also allows taken full benefits from the information already available from Internet, such as the 3D object libraries. This contribution describes, step by step, the method that allows 3DPV to evaluate the PV energy losses caused by complex shading. We then illustrate the results of this methodology to several application cases that are encountered in the world of PV systems design.
description: 5 page, 9 figures, conference proceedings, 29th European Photovoltaic Solar Energy Conference and Exhibition, Amsterdam, 2014
MECHANICAL MAPPING OF NEURAL TUBE CLOSURE IN LIVE EMBRYOS USING BRILLOUIN MICROSCOPY
Creators: name: Handler, Chenchen
Publisher: name: Digital Repository at the University of Maryland
Year: 2022
Subjects: subject: Optics
subject: Bioengineering
subject: Developmental biology
subject: Birth defects
subject: Brillouin microscopy
subject: Mechanical mapping
subject: Neural tube closure
subject: Neurulation
subject: Stiffness

description: Neurulation is a process that serves as the precursor to the spinal cord in vertebrates. Neural tube closure (NTC), part of primary neurulation, involves the extensive coordination of cellular, molecular, and mechanical events to transform the flat neural epithelium to a luminated epithelial tube. Neural tube defects (NTD) are the result of mechanical failures that arise during neurulation. Recent research has focused on understanding the molecular mechanisms underlying neurulation but has difficulty correlating them to physical mechanisms. To better understand how physical mechanisms are integrated and responsible for neurulation, several techniques have been applied to study NTC in a range of in vitro environments. However, many of these techniques have been limited due requiring the specimen to be fixed and/ or being invasive and requiring physical contact with the specimen to extract the modulus. As such, there is limited resolution and only the superficial layer of the sample is measured making assessing 2D/3D tissue mechanics inside a growing organism is highly challenging. In this dissertation, we aim to quantify the mechanical state of the neural tube without disruption to development. To do this, we adapted Brillouin microscopy, a non-invasive, label- and contact-free imaging technique, to allows us to probe thelongitudinal modulus of the neural plate at every step of NTC with cellular resolution. This quantification is performed as the embryo develops in real time using time-lapse Brillouin and an improved ex-ovo culture method. We observed an increase in the Brillouin modulus of the neural plate as the embryo develops from Hamburger-Hamilton stage (HH)-6 to HH-12. This increase in modulus is consistent with previous data from other vertebrates such as Xenopus and Mouse embryos and demonstrates the process of neurulation is driven by mechanical forces. Time-lapse Brillouin imaging depicted stiffening and thickening of the neural plate during NTC, suggesting these are coordinated events for NTC. Here, we show that tissue stiffness plays an integral role in NTC and directly quantifying tissue mechanics during neurulation should allow us to better determine the biomechanical nature of NTD.
Letter from Richard Trevino to Mark Wolfe, Memorandum for Proposed Replacement of Copper Gutters and Down Spouts on Housing Units, Randolph Air Force Base, Texas
Creators: name: Trevino, Richard
Publisher: name: Department of the Air Force, Air Education and Training Command
Year: 2011
Subjects: subject: Randolph Field Historic Landmark District
valueUri: https://core.tdar.org/browse/geographic-keyword/83364/randolph-field-historic-landmark-district
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Randolph Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/78971/randolph-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Domestic Structures
valueUri: https://core.tdar.org/browse/site-type/256/domestic-structures
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: House
valueUri: https://core.tdar.org/browse/site-type/259/house
subject: Domestic Structure or Architectural Complex
valueUri: https://core.tdar.org/browse/site-type/251/domestic-structure-or-architectural-complex
subject: Copper Gutter
valueUri: https://core.tdar.org/browse/other-keyword/158195/copper-gutter
subject: Housing Units
valueUri: https://core.tdar.org/browse/other-keyword/158168/housing-units
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: This letter provides documentation, including a memorandum, for the proposed replacement of copper gutters and down spouts on housing units listed on the National Register of Historic Places and located within the Randolph Field Historic Landmark District. Randolph Air Force Base has determined that the undertaking will alter the exterior design of the structures but not in a manner that would diminish the integrity of the properties and their historic affiliations. Copied to this correspondence is the San Antonio Conservation Society.
Cloning and variation of ground state intestinal stem cells
Creators: name: Wu, Lingyan
name: Lacy, D. Borden
name: Xian, Wa
name: Sylvester, Francisco A.
name: Ning, Gang
name: Zhang, Ting
name: Yamamoto, Yusuke
name: Hyams, Jeffrey S.
name: Nagarajan, Niranjan
name: Ho, Khek Yu
name: Howitt, Brooke E.
name: Bertrand, Denis
name: Farrow, Melissa A.
name: Chevalier, Benoit
name: McKeon, Frank
name: Crum, Christopher P.
name: Wilson, Lane H.
name: Hong, Yue
name: Khor, Chiea Chuen
name: Devers, Thomas
name: Kern, Florian
name: Wang, Xia
name: Bronson, Roderick
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Stem cells of the gastrointestinal tract, pancreas, liver, and other columnar epithelia collectively resist cloning in their elemental states. Here we demonstrate the cloning and propagation of highly clonogenic, “ground state” stem cells of the human intestine and colon. We show that derived stem cell pedigrees sustain limited copy number and sequence variation despite extensive serial passaging and display exquisitely precise, cell-autonomous commitment to epithelial differentiation consistent with their origins along the intestinal tract. This developmentally patterned and epigenetically maintained commitment of stem cells likely enforces the functional specificity of the adult intestinal tract. Using clonally-derived colonic epithelia, we show that toxins A or B of the enteric pathogen C. difficile recapitulate the salient features of pseudomembranous colitis. The stability of the epigenetic commitment programs of these stem cells, coupled with their unlimited replicative expansion and maintained clonogenicity, suggests certain advantages for their use in disease modeling and regenerative medicine.
Abiotic hydrolysis of the detergent builder tripolyphosphate by hydrous manganese dioxide
Creators: name: Inman, Matthew P
name: Beattie, James K
name: Jones, David R
name: Baldwin, Darren S
Publisher: name: La Trobe
Year: 2023

description: La Trobe University Faculty of Science, Technology and Engineering Murray Darling Freshwater Research Centre

MDFRC item.

The hydrolysis of tripolyphosphate to orthophosphate is facilitated by suspensions ofamorphous manganese dioxide. Pyrophosphate is observed as an intermediate. The rate enhancementdecreases with increasing pH. The weak sorption of orthophosphate on the oxide also decreases withincreasing pH, indicating that the orthophosphate product would be bioavailable. The presence of calciumions in natural waters increases both the rate of hydrolysis of tripolyphosphate and the extent of sorptionof orthophosphate. Under some circumstances this abiotic mechanism could play a significant role in thehydrolysis of tripolyphosphate in the aquatic environment.
OAHP Inventory, Building 5132 Detached Lavatory Building, Camp Bullis, Texas
Creators: name: Office Of Archeology And Historic Preservation, Department Of The Interior
Publisher: name: Office of Archeology and Historic Preservation, Department of the Interior
Year: 1978
Subjects: subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Camp Bullis
valueUri: https://core.tdar.org/browse/geographic-keyword/82533/camp-bullis
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: Non-Domestic Structures
valueUri: https://core.tdar.org/browse/site-type/309/non-domestic-structures
subject: Lavatory
valueUri: https://core.tdar.org/browse/other-keyword/158259/lavatory
subject: OAHP
valueUri: https://core.tdar.org/browse/other-keyword/138292/oahp
subject: Building 5132
valueUri: https://core.tdar.org/browse/other-keyword/146746/building-5132
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Historic Background Research
valueUri: https://core.tdar.org/browse/investigation-type/18/historic-background-research
subject: Architectural Survey
valueUri: https://core.tdar.org/browse/investigation-type/2/architectural-survey
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: An Office of Archaeology and Historic Preservation inventory form for Building 5132 at Camp Bullis, Texas. The structure was built in 1940 and serves as a detached lavatory building.
Rural Conditions and Trends
Creators: name: USDA ERS
name: USDA ERS
Publisher: name: Unknown
Year: 1994
Subjects: Community/Rural/Urban Development

description: Overview: Revisions and Redesigns Affect Reporting of Rural Conditions, But Trends Remain the Same; National Economic Conditions: Growth Strong Into Second Half of 1994, Fed Keeps Acting to Curb Inflation; Employment: Rural Employment Increases in First Half of 1994; Unemployment: Rural Unemployment Varies Across Localities, But Continues to Fall; Industry: Rural Job Growth Sustained by Service-Producing Industries During 1992; Earnings: Rural Nonfarm Earnings Edged Upward in 1992; Farm Income: Disasters Lowered Farm Income in 1993; Appendix: Data Sources and Definitions; Appendix Tables
Deterministic homogenization for fast-slow systems with chaotic noise
Creators: name: Kelly, David
name: Melbourne, Ian
Publisher: name: arXiv
Year: 2014
Subjects: subject: Probability (math.PR)
subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 60H10, 37D20, 37D25, 37A50

description: Consider a fast-slow system of ordinary differential equations of the form $\dot x=a(x,y)+\varepsilon^{-1}b(x,y)$, $\dot y=\varepsilon^{-2}g(y)$, where it is assumed that $b$ averages to zero under the fast flow generated by $g$. We give conditions under which solutions $x$ to the slow equations converge weakly to an Itô diffusion $X$ as $\varepsilon\to0$. The drift and diffusion coefficients of the limiting stochastic differential equation satisfied by $X$ are given explicitly. Our theory applies when the fast flow is Anosov or Axiom A, as well as to a large class of nonuniformly hyperbolic fast flows (including the one defined by the well-known Lorenz equations), and our main results do not require any mixing assumptions on the fast flow.
description: 31 pages
Guidelines for Business Operation for Increasing the Competitive Advantage in Aviation and Tourism Industry after COVID-19 Pandemic in Thailand
Creators: name: Dultadej Sanvises
Publisher: name: DR.KEN Institute of Academic Development and Promotion.
Year: 2023
Subjects: Competitive Advantage
Aviation
Tourism Industry
COVID-19

description: Interdisciplinary Academic and Research Journal, 3, 3, 767-778