cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A concise and regioselective synthesis of 6-bromo-5-methoxy-1H-indole-3-carboxylic acid and its derivatives: Strategic development toward core moiety of Herdmanine D
Creators: name: Sharma, Pankaj
name: Sharma, Nutan
name: Kashyap, Gunjan
name: Bhagat, Sunita
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: A concise, regioselective and highly efficient strategy for the construction of 6-bromo-5-methoxy-1H-indole-3-carboxylic acid has been developed through trifluoroacetylated indole driven hydrolysis. The developed protocol has the advantage of selectively directing bromine substituent on one position. The formation of this regioselective product was confirmed by 1HNMR data. The attractive feature of this new strategy is that the 6-bromo-5-methoxy-1H-indole-3-carboxylic acid is an important scaffold of anti-inflammatory naturally occurring compound Herdmanine D. Furthermore, bromo indoles bearing carboxylic acid group were further functionalized in amide derivatives by using various aromatic/aliphatic amines through ultrasonic irradiation.
Additional file 2 of Student usage of open educational resources and social media at a Sri Lanka Medical School
Creators: name: Hettige, Samankumara
name: Dasanayaka, Eshani
name: Ediriweera, Dileepa Senajith
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Plant Biology

description: Additional file 2: Supplementary material 2. Questionnaire items in this study. Questionnaire items used to collect data. Student Usage of Open Educational Resources and Social Media at a Sri Lanka Medical School. Samankumara Hettige, Eshani Dasanayaka and Dileepa Senajith Ediriweera.
Modal dynamics for positive operator measures
Creators: name: Gambetta, Jay
name: Wiseman, H. M.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The modal interpretation of quantum mechanics allows one to keep the standard classical definition of realism intact. That is, variables have a definite status for all time and a measurement only tells us which value it had. However, at present modal dynamics are only applicable to situations that are described in the orthodox theory by projective measures. In this paper we extend modal dynamics to include positive operator measures (POMs). That is, for example, rather than using a complete set of orthogonal projectors, we can use an overcomplete set of nonorthogonal projectors. We derive the conditions under which Bell's stochastic modal dynamics for projective measures reduce to deterministic dynamics, showing (incidentally) that Brown and Hiley's generalization of Bohmian mechanics [quant-ph/0005026, (2000)] cannot be thus derived. We then show how {\em deterministic} dynamics for positive operators can also be derived. As a simple case, we consider a Harmonic oscillator, and the overcomplete set of coherent state projectors (i.e. the Husimi POM). We show that the modal dynamics for this POM in the classical limit correspond to the classical dynamics, even for the nonclassical number state $\ket{n}$. This is in contrast to the Bohmian dynamics, which for energy eigenstates, the dynamics are always non-classical.
description: 14 pages
Additional file 1 of Sequentially calibrating a Bayesian microsimulation model to incorporate new information and assumptions
Creators: name: DeYoreo, Maria
name: Rutter, Carolyn M.
name: Ozik, Jonathan
name: Collier, Nicholson
Publisher: name: figshare
Year: 2022
Subjects: subject: Statistics
subject: FOS: Mathematics

description: Additional file 1: Description of the Incremental Mixture Approximate Bayesian Computation Algorithm.
Anasterias studeri Perrier 1891
Creators: name: Jangoux, Michel
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Asteroidea
Forcipulatida
Asteriidae
Anasterias
Anasterias studeri

description: studeri Perrier, 1891, Anasterias
(Fig. 30)
Anasterias studeri Perrier, 1891: 99. — Clark in Clark & Mah 2001: 247.
CURRENT STATUS. — Anasterias studeri Perrier, 1891.
TYPE MATERIAL. — Falkland Islands • holotype; Cape Horn expedition (1882-1883); 320 m; MNHN-IE-2014-83.
description: Published as part of Jangoux, Michel, 2022, The type specimens of extant asteroids (Echinodermata) in the Muséum national d'Histoire naturelle of Paris, pp. 259-334 in Zoosystema 44 (11) on pages 319-320, DOI: 10.5252/zoosystema2022v44a11, http://zenodo.org/record/6616817
Additional file 7 of Isolation and characterisation of ΦcrAss002, a crAss-like phage from the human gut that infects Bacteroides xylanisolvens
Creators: name: Guerin, Emma
name: Shkoporov, Andrey N.
name: Stockdale, Stephen R.
name: Comas, Joan Colom
name: Khokhlova, Ekaterina V.
name: Clooney, Adam G.
name: Daly, Karen M.
name: Draper, Lorraine A.
name: Stephens, Niamh
name: Scholz, Dimitri
name: R. Paul Ross
name: Hill, Colin
Publisher: name: figshare
Year: 2021
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional file 6: Figure S3. Phylogenetic tree of large terminase subunits encoded by published complete genomes of crAss-like phages. Protein sequences were aligned using MUSCLE, approximately-maximum-likelihood phylogenetic trees were generated using FastTree. Branch support values calculated using SH-test. Tree tip colours correspond to candidate genera as proposed in [19]. ΦcrAss002 label is highlighted in red. Previously well-characterised uncultured phage genomes and cultured isolates are highlighted in boldface font. Accession numbers of genomes in NCBI GenBank/RefSeq/WGS databases are provided.
Equation of motion for a bound system of charged particles
Creators: name: Pachucki, Krzysztof
name: Yerokhin, Vladimir A.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We consider a bound system of charged particles moving in an external electromagnetic field, including leading relativistic corrections. The difference from the point particle with a magnetic moment comes from the presence of polarizabilities. Due to the lack of separation of the total momentum from the internal degrees of freedom, the notion of polarizability of the bound state immersed in the continuum spectrum of the global motion is nontrivial. We introduce a bound-continuum perturbation theory and obtain a complete formula for the equation of motion for a polarizable bound system, such as atom, ion, or the nucleus. This formula may find applications when high precision is sought and small effects due polarizabilities are important.
description: 8 pages
On a problem of A. Weil
Creators: name: Nikolaev, Igor
Publisher: name: arXiv
Year: 2004
Subjects: subject: Geometric Topology (math.GT)
subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 57M50

description: A topological invariant of the geodesic laminations on a modular surface is constructed. The invariant has a continuous part (the tail of a continued fraction) and a combinatorial part (the singularity data). It is shown, that the invariant is complete, i.e. the geodesic lamination can be recovered from the invariant. The continuous part of the invariant has geometric meaning of a slope of lamination on the surface.
description: to appear Beitr\"age zur Algebra und Geometrie
Roger of Hereford’s Judicial Astrology: England’s First Astrology Book?
Creators: name: Mitchell, Christopher J.
Publisher: name: University of Leicester
Year: 2020
Subjects: Uncategorized

description: The twelfth century saw a large number of Arabic texts on natural philosophy translated into Latin for the first time. Many of these texts were astrological, and had originally been translated into Arabic in the eighth and ninth centuries, shortly after the rise of Islam, from original Greek, Persian and Indian sources. Knowledge of astrology in Western Europe prior to the twelfth century was limited, although the need for Christians to calculate the date of Easter meant that an understanding of solar and lunar cycles was important, leading to the development of the science of computus, taught in secular cathedral schools, which were the main centres of learning in England in the twelfth century. One school with a reputation for scientific learning was the cathedral school at Hereford, and this research focuses on a text of a teacher there, Roger of Hereford, who compiled the newly-translated Arabic material on astrology into a single book, Judicial Astrology.By the thirteenth century, astrology had become an established part of the curriculum taught in newly-established universities across Europe, and included studying works by Arabic astrologers that had been translated into Latin. What has not been researched in detail until now, though, is how astrology was taught in that century between the translation of Arabic texts and its establishment as part of the quadrivium in universities, and a detailed examination of Roger’s seminal book.This thesis examines his Judicial Astrology in detail, analysing the astrological techniques used, identifying Roger’s sources, and looking at his teaching methods.This thesis sets the context within which astrological texts were translated, and provides an analysis of every extant manuscript of Judicial Astrology. The conclusion examines Roger’s claim that he compiled the first astrology book in England, and asks whether it still stands as a usable text today.
Neochauliodes punctatolosus Liu & Yang
Creators: name: Liu, Xingyue
name: Hayashi, Fumio
name: Yang, Ding
Publisher: name: Zenodo
Year: 2007
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Megaloptera
Corydalidae
Neochauliodes
Neochauliodes punctatolosus

description: Neochauliodes punctatolosus Liu & Yang
(Fig. 45)
 Neochauliodes punctatolosus Liu et Yang, 2006a. Ann. Zool. 56: 193. Type locality: Yunnan (Xishuangbanna, Jingdong, Zhenyuan, Yiliang, Hekou, Mangshi, Jinping, Simao).
 Specimens examined. THAILAND: 2 ♂, Chiang Dao, 12. V.2004, I. Sivec & H. Bogdan (CAU); 3 ♂, Chiangmai, Doi Pui, 7. VI.1986 (HC); ♀, Rt. 1242, 30. V.2004 (HC); ♀, Chiangmai, near Doi Suthep, reared from a larva in 1999 (HC); LAOS: 2 ♂, Ban Saleui N.E., Mt. Pan, 30.IV.2003 (♂ in CAU, ♂ in HC); VIETNAM: ♀, 14.VIII.2000 (CAU).
 Distribution. China (Yunnan); Laos; Thailand; Vietnam.
 Remarks. We report this species from Thailand, Laos and Vietnam for the first time. Because N. punctatolosus was frequently present in Neochauliodes collections from southeastern Asia, we feel this might be a common species in southeastern Asia and will probably be found from Myanmar. Detailed comparison of this species to other relatives is presented in Liu & Yang (2006a).
description: Published as part of Liu, Xingyue, Hayashi, Fumio & Yang, Ding, 2007, Revision of the Neochauliodes sinensis species-group (Megaloptera: Corydalidae: Chauliodinae), pp. 29-54 in Zootaxa 1511 (1) on pages 43-44, DOI: 10.11646/zootaxa.1511.1.3, http://zenodo.org/record/5087291
Paragonaster subtilis
Creators: name: Jangoux, Michel
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Asteroidea
Paxillosida
Pseudarchasteridae
Paragonaster
Paragonaster subtilis

description: strictus Perrier, 1894, Paragonaster
Paragonaster strictus Perrier, 1894: 363, pl. 25, fig. 5a, b.
Paragonaster subtilis ‒ Clark & Downey 1992: 256.
CURRENT STATUS. — Paragonaster subtilis (Perrier, 1881).
TYPE MATERIAL. — Atlantic Ocean • 3 syntypes; station 102; between Dakar (Senegal) and La Praia (Cape Verde Islands); Talisman expedition; 1883; 15°48’N, 22°43’W; depth 3655 m; MNHN- IE-2014-121.
description: Published as part of Jangoux, Michel, 2022, The type specimens of extant asteroids (Echinodermata) in the Muséum national d'Histoire naturelle of Paris, pp. 259-334 in Zoosystema 44 (11) on page 319, DOI: 10.5252/zoosystema2022v44a11, http://zenodo.org/record/6616817
Relation between geometric phases of entangled bi-partite systems and their subsystems
Creators: name: Tong, D. M.
name: Sjöqvist, E.
name: Kwek, L. C.
name: Oh, C. H.
name: Ericsson, M.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: This paper focuses on the geometric phase of entangled states of bi-partite systems under bi-local unitary evolution. We investigate the relation between the geometric phase of the system and those of the subsystems. It is shown that (1) the geometric phase of cyclic entangled states with non-degenerate eigenvalues can always be decomposed into a sum of weighted non-modular pure state phases pertaining to the separable components of the Schmidt decomposition, though the same cannot be said in the non-cyclic case, and (2) the geometric phase of the mixed state of one subsystem is generally different from that of the entangled state even by keeping the other subsystem fixed, but the two phases are the same when the evolution operator satisfies conditions where each component in the Schmidt decomposition is parallel transported.
Additional file 1 of Spatial heterogeneity of tumor microenvironment influences the prognosis of clear cell renal cell carcinoma
Creators: name: Zhang, Dawei
name: Ni, Yuanli
name: Wang, Yongquan
name: Feng, Juan
name: Zhuang, Na
name: Li, Jiatao
name: Liu, Limei
name: Shen, Wenhao
name: Zheng, Ji
name: Zheng, Wei
name: Qian, Cheng
name: Shan, Juanjuan
name: Zhou, Zhansong
Publisher: name: figshare
Year: 2023
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1: Figure S1. (A) Combined tSNE plot illustrating the origin of the 27 cell clusters, which are colored according to tissues. The letter A reflects the paracancerous tissue, the letter T reflects the cancerous tissue. (B) Proportions of the 27 cell clusters in total cells from the 13 ccRCC and paired paracancerous tissues. (C) tSNE plots depicting the expression of 17 markers across the 27 cell clusters, respectively. (D) Comparison of the proportion of 27 cell clusters between the ccRCC and paired paracancerous tissues.
CORTIS-HR: Statistical Analysis Plan
Creators: name: Mendelsohn, Simon
name: Scriba, Thomas
name: Fiore-Gartland, Andrew
name: Hatherill, Mark
name: Bhavesh Borate
Publisher: name: University of Cape Town
Year: 2020
Subjects: subject: Immunology
subject: FOS: Clinical medicine
subject: 100402 Medical Biotechnology Diagnostics (incl. Biosensors)
subject: FOS: Medical biotechnology

description: Statistical Analysis Plan: 11-gene Correlates of Risk (COR) Diagnostic and Predictive Performance Analysis in HIV-Infected Adults in the "Validation of Correlates of Risk of TB Disease in High Risk Populations (CORTIS-HR): A companion study of the CORTIS-01 Trial"
Version: 1.0Date: 11 December 2019
The 2003 eclipse of EE Cep is coming. A review of past eclipses
Creators: name: Graczyk, D.
name: Mikolajewski, M.
name: Tomov, T.
name: Kolev, D.
name: Iliev, I.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: EE Cep is an eclipsing binary with a period of 5.6 years. The next eclipse will occur soon, in May-June 2003, and all available past eclipses were collected and briefly analysed. EE Cep shows very large changes of the shape and the depth of minima during different eclipses, however it is possible to single out some persistent features. The analysis suggests that the eclipsing body should be a long object surrounded by an extended semi-transparent envelope. As an explanation, a model of a precessing optically thick disc, inclined to the plane of the binary orbit, is invoked. The changes of its spatial orientation, which is defined by the inclination of the disc and the tilt, induced most probably by precession of the disc spin axis with a period of about 50 years, produce strange photometric behaviour of this star. The H_alpha emission, and possibly the NaI absorptions, show significant changes during several months outside of the eclipse phase.
description: 7 pages, 7 figures, LaTeX2e, accepted by A&A
Search for jet quenching effects in high multiplicity pp collisions at $\sqrt{\mathrm{s}}$=13 TeV
Creators: name: Jacobs, P. M.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The ALICE Collaboration reports a search for jet quenching effects in pp collisions at $\sqrt{\mathrm{s}}$=13 TeV, in events selected on high multiplicity compared to the minimum bias population. The measurement is based on the semi-inclusive acoplanarity distribution of jets recoiling from a high-$p_\mathrm{T}$ trigger hadron. Significant broadening of the recoil jet acoplanarity distribution is observed in high multiplicity pp collisions, in both data and in simulations based on the PYTHIA model. Analysis is ongoing to elucidate the origin of this effect.
description: Proceedings of the XXVIIIth Conference on Ultrarelativistic Nucleus-Nucleus Collisions (Quark Matter 2019), Wuhan, China
Henricia studeri
Creators: name: Jangoux, Michel
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Asteroidea
Spinulosida
Echinasteridae
Henricia
Henricia studeri

description: studeri Perrier, 1891, Cribrella
Cribrella studeri Perrier, 1891: 102, pl. 9, fig. 2a, b.
Henricia studeri ‒ Clark 1996: 243.
CURRENT STATUS. — Henricia studeri (Perrier, 1891).
TYPE MATERIAL. — Tierra del Fuego Archipelago • holotype; south of Cape Horn; Cape Horn expedition (1882-1883); depth 99 m; MNHN-IE-2014-280.
description: Published as part of Jangoux, Michel, 2022, The type specimens of extant asteroids (Echinodermata) in the Muséum national d'Histoire naturelle of Paris, pp. 259-334 in Zoosystema 44 (11) on page 320, DOI: 10.5252/zoosystema2022v44a11, http://zenodo.org/record/6616817
Additional file 8 of Isolation and characterisation of ΦcrAss002, a crAss-like phage from the human gut that infects Bacteroides xylanisolvens
Creators: name: Guerin, Emma
name: Shkoporov, Andrey N.
name: Stockdale, Stephen R.
name: Comas, Joan Colom
name: Khokhlova, Ekaterina V.
name: Clooney, Adam G.
name: Daly, Karen M.
name: Draper, Lorraine A.
name: Stephens, Niamh
name: Scholz, Dimitri
name: R. Paul Ross
name: Hill, Colin
Publisher: name: figshare
Year: 2021
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional file 7: Figure S4. Multiple site-specific recombinase-encoding genes and evidence of dynamic recombinations in the genome of B. xylanisolvens APCS1/XY. a Circular map of genome (the innermost circle [green and purple], GC skew; circle two [black], relative G+C content; circles three and four [red and dark blue], open reading frames identified on the positive and negative DNA strands respectively; circle five [orange], tRNA and rRNA genes. circle six, genes annotated as Sus-like surface-associated glycan utilisation proteins [green] and TonB-dependent nutrient receptor [light blue]; circle seven [black], genes annotated as invertases, integrases and recombinases). To the right of the genome map, circular maps of the two associated circular plasmids are shown; pBXS1-1 and pBXS1-2. Annotated features are coloured and labelled; b Distribution of length of Oxford Nanopore sequencing reads used for dynamic genome recombination analysis; c Distribution of percentage identity in Oxford Nanopore reads aligned using BLASTn to the chromosome scaffold; d Frequency of detected recombinations at a single read level (reads of at least 1000nt, with individual alignments of >90% identity and >200nt length; all inversions or shifts in coordinates >200 nt were deemed as recombinations) versus coordinates in the chromosome scaffold (histogram bin size = 1000bp); recombination hotspots were identified when >8 reads with inconsistent alignment were present per 1000bp bin; gene products overlapping with hotspots are marked on the plot.
Semiclassical catastrophes and accumulative angular squeezing of a kicked quantum rotor
Creators: name: Leibscher, M.
name: Averbukh, I. Sh.
name: Rozmej, P.
name: Arvieu, R.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present a detailed theory of spectacular semiclassical catastrophes happening during the time evolution of a kicked quantum rotor (Phys.Rev. Lett. {\bf 87}, 163601 (2001)). Both two- and three-dimensional rotational systems are analyzed. It is shown that the wave function of the rotor develops a {\em cusp} at a certain delay after a kick, which results in a sharply focused rotational wave packet. The {\em cusp} is followed by a fold-type catastrophe manifested in the {\em rainbow}-like moving angular singularities. In the three-dimensional case, the rainbows are accompanied by additional singular features similar to {\em glory} structures known in wave optics. These catastrophes in the time-dependent angular wave function are well described by the appropriate tools of the quasiclassical wave mechanics, i.e. by Airy and Bessel approximations and Pearcey's functions. A scenario of "accumulative squeezing" is also presented in which a specially designed train of short kicks produces an unlimited narrowing of the rotor angular distribution. This scenario is relevant for the molecular alignment by short laser pulses, and also for atom lithography schemes in which cold atoms are focused by an optical standing wave.
description: 22 pages, 12 postscript figures, 2 jpeg figures
$M(B^*_c)-M(B_c)$ Splitting from Nonrelativistic Renormalization Group
Creators: name: Penin, A. A.
name: Pineda, A.
name: Smirnov, V. A.
name: Steinhauser, M.
Publisher: name: arXiv
Year: 2004
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We compute the hyperfine splitting in a heavy quarkonium composed of different flavors in next-to-leading logarithmic approximation using the nonrelativistic renormalization group. We predict the mass difference of the vector and pseudoscalar charm-bottom mesons to be $M(B^*_c)-M(B_c)=46 \pm 15 {(\rm th)} {}^{+13}_{-11} (δα_s)$ MeV.
description: Eq.(22) and Appendix corrected, numerical results slightly changed. arXiv admin note: text overlap with arXiv:hep-ph/0312086
Investigation into the in vivo and in vitro effects of anti-angiogenic therapy on abdominal aortic aneurysms
Creators: name: Vijaynagar, Badri
Publisher: name: University of Leicester
Year: 2020
Subjects: Uncategorized

description: Medical therapy to prevent abdominal aortic aneurysm (AAA) development and progression is not currently available. Angiogenesis and extracellular signal-related kinase (ERK) pathway are key modulators of matrix metallo proteinases (MMPs) during AAA formation. The aim of the study described in this thesis is to evaluate the effects of Sorafenib (a multikinase inhibitor with antiangiogenic and ERK inhibitory properties) on experimental AAAs, and its in-vitro equivalent, 5-Br SU6668, on co-cultures of human AAA smooth muscle cells (SMCs) with aortic endothelial cells (AECs).To study in vivo effects, Apolipoprotein E knock out (ApoE-/-) mice were assigned to either 28 days of angiotensin-II (AngII) infusion alone (Group 1); AngII+Sorafenib from day-1 (Group 2); AngII+Sorafenib from day-10 (Group 3); or saline infusion (negative control, Group 4). Sorafenib reduced the development (Group-2 versus Group-1, P=0.001) and progression (Group-3 versus Group-1, P=0.0002) of AAAs. Mice treated with Sorafenib resulted in greater preservation of elastin and collagen layers within their aortic wall and significantly reduced angiogenesis (CD34 cells), inflammatory infiltrates, expression of pro-angiogenic genes (Raf1, Nras, Pi3k, Akt3, Vegf, Il6) and MMP-2 and -9 protein expressions (all P<0.05).In-vitro, 5-Br SU6668 prevented ERK phosphorylation and reduced gene expression of pro-angiogenic cytokine {Interleukin -6 (IL-6), P=0.04} and protein levels of pro-angiogenic peptides {Monocyte Chemotactic Protein-1(MCP-1) and MMP2, P<0.05) in co-cultures of human AAA SMCs and AECs.Targeting the angiogenic pathway via inhibition of ERK phosphorylation is a potential therapy to prevent AAA growth. Whether anti-angiogenic therapy reduces human AAA development and growth warrants further investigation.
Timescales of Soft X-Ray Variability and Physical Constraints in Agns
Creators: name: Bian, W.
name: Zhao, Y.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present soft X-ray variability time-scales for 65 active galactic nuclei (AGNs) derived from ROSAT/PSPC pointing data. For these 65 objects with obvious exponential increasing or decreasing patterns in their light curves, we use the exponential time-scales and find they are more suitable for analyzing ROSAT light curve data. We also discuss some physical constraints on the central engine implied by our results. Assuming that this soft X-ray variability exponential time-scale is approximately equal to the thermal timescale of the standard accretion disk, we obtain the accretion rate, the size of soft x-ray radiation region and the compactness parameter for 37 AGNs, using their recently estimated central black hole masses. For 12 of these 37 AGNs, the radii of the gravitational instability in the standard thin accretion disks are obtained using central black hole masses and the calculated accretion rates. These are consistent with the results from the reverberation mapping method. These results provide supporting evidence that such gravitational instabilities contribute to the formation of the Broad Line Regions (BLRs) in AGNs.
description: 22 pages, 9 figures, 2 tables, accepted for publication in ApJ(for v591, July)
Additional file 2 of Spatial heterogeneity of tumor microenvironment influences the prognosis of clear cell renal cell carcinoma
Creators: name: Zhang, Dawei
name: Ni, Yuanli
name: Wang, Yongquan
name: Feng, Juan
name: Zhuang, Na
name: Li, Jiatao
name: Liu, Limei
name: Shen, Wenhao
name: Zheng, Ji
name: Zheng, Wei
name: Qian, Cheng
name: Shan, Juanjuan
name: Zhou, Zhansong
Publisher: name: figshare
Year: 2023
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 2: Figure S2. (A) Heatmap representing the abundance of 7 major cells across different ccRCC tissues. The proportions were normalized by z-score for visualization. (B) Mean density curves showing the expression of 17 markers across total cells from 75 ccRCC tissues, respectively. The knee points are set as threshholds to determine the positive cells. (C) Comparison of survivals between high and low immune cell groups. High group, tissues with proportion of the immune cells ≥the third quartile (Q3); Low group, tissues with proportion of the immune cells ≤the first quartile (Q1). (D) Annotation rules for determining subtypes of T cells and macrophages.
Coupling the circadian rhythms of population movement and the immune system in infectious disease modeling
Creators: name: Du, Zhanwei
name: Holme, Petter
Publisher: name: arXiv
Year: 2019
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: FOS: Biological sciences

description: The dynamics of infectious diseases propagating in populations depends both on human interaction patterns, the contagion process and the pathogenesis within hosts. The immune system follows a circadian rhythm and, consequently, the chance of getting infected varies with the time of day an individual is exposed to the pathogen. The movement and interaction of people also follow 24-hour cycles, which couples these two phenomena. We use a stochastic metapopulation model informed by hourly mobility data for two medium-sized Chinese cities. By this setup, we investigate how the epidemic risk depends on the difference of the clocks governing the population movement and the immune systems. In most of the scenarios we test, we observe circadian rhythms would constrain the pace and extent of disease emergence. The three measures (strength, outward transmission risk and introduction risk) are highly correlated with each other. For example of the Yushu City, outward transmission risk and introduction risk are correlated with a Pearson's correlation coefficient of 0.83, and the risks correlate to strength with coefficients of $-0.85$ and $-0.75$, respectively (all have $p<0.05$), in simulations with no circadian effect and $R_0=1.5$. The relation between the circadian rhythms of the immune system and daily routines in human mobility can affect the pace and extent of infectious disease spreading. Shifting commuting times could mitigate the emergence of outbreaks.
Reply to "Comment on 'Universal Behavior of Load Distribution in Scale-Free Networks'"
Creators: name: Goh, K. -I.
name: Ghim, C. -M.
name: Kahng, B.
name: Kim, D.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Reply to "Comment on 'Universal Behavior of Load Distribution in Scale-Free Networks.'"
description: 1 page, 1 figure
Additional file 2 of Na+/Ca2+ exchanger isoform 1 takes part to the Ca2+-related prosurvival pathway of SOD1 in primary motor neurons exposed to beta-methylamino-l-alanine
Creators: name: Petrozziello, Tiziana
name: Boscia, Francesca
name: Tedeschi, Valentina
name: Pannaccione, Anna
name: de Rosa, Valeria
name: Corvino, Angela
name: Severino, Beatrice
name: Annunziato, Lucio
name: Secondo, Agnese
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Plant Biology

description: Additional file 1. (A) Immunolocalization of NCX1 (a,d) and MAP2 (b,e) within a motor-neuron enriched culture under control conditions. Nuclei were stained with nuclear DNA stain 4, 6-diamino-2-phenylinndole (DAPI). Arrows indicate MAP2-positive cells with higher level of NCX1 expression. (B) Immunolocalization of NCX1 and NCX3 in differentiated NSC-34 cells. (C) Quantification of SOD1-induced [Ca2+]i in presence of CNQX (20 μM), MK801 (10 μM), or CB-DMB (1 μM) in motor neurons expressed as △% of increase. All the experiments were repeated at least three times on at least 35 cells for each group; *p < 0.001 vs control (basal values of [Ca2+]i) .
TaxoExpan: Self-supervised Taxonomy Expansion with Position-Enhanced Graph Neural Network
Creators: name: Shen, Jiaming
name: Shen, Zhihong
name: Xiong, Chenyan
name: Wang, Chi
name: Wang, Kuansan
name: Han, Jiawei
Publisher: name: arXiv
Year: 2020
Subjects: subject: Computation and Language (cs.CL)
subject: Artificial Intelligence (cs.AI)
subject: Information Retrieval (cs.IR)
subject: FOS: Computer and information sciences

description: Taxonomies consist of machine-interpretable semantics and provide valuable knowledge for many web applications. For example, online retailers (e.g., Amazon and eBay) use taxonomies for product recommendation, and web search engines (e.g., Google and Bing) leverage taxonomies to enhance query understanding. Enormous efforts have been made on constructing taxonomies either manually or semi-automatically. However, with the fast-growing volume of web content, existing taxonomies will become outdated and fail to capture emerging knowledge. Therefore, in many applications, dynamic expansions of an existing taxonomy are in great demand. In this paper, we study how to expand an existing taxonomy by adding a set of new concepts. We propose a novel self-supervised framework, named TaxoExpan, which automatically generates a set of pairs from the existing taxonomy as training data. Using such self-supervision data, TaxoExpan learns a model to predict whether a query concept is the direct hyponym of an anchor concept. We develop two innovative techniques in TaxoExpan: (1) a position-enhanced graph neural network that encodes the local structure of an anchor concept in the existing taxonomy, and (2) a noise-robust training objective that enables the learned model to be insensitive to the label noise in the self-supervision data. Extensive experiments on three large-scale datasets from different domains demonstrate both the effectiveness and the efficiency of TaxoExpan for taxonomy expansion.
description: WWW 2020
Nymphaster arenatus
Creators: name: Jangoux, Michel
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Asteroidea
Valvatida
Goniasteridae
Nymphaster
Nymphaster arenatus

description: subspinosus Perrier, 1881, Pentagonaster
Pentagonaster subspinosus Perrier, 1881: 5; 1884: 234, pl. 6, fig. 1.
Nymphaster arenatus ‒ Clark & Downey 1992: 254.
CURRENT STATUS. — Nymphaster arenatus (Perrier, 1881).
TYPE MATERIAL. — Caribbean Sea • 1 syntype; station 246; Carriacou (Grenadines Islands); BLAKE expedition; 1878-1879; depth 298 m; MNHN-IE-2014-566 • 1 syntype; Barbados; same as for preceding; depth 382 m; MNHN-IE-2014-1341.
description: Published as part of Jangoux, Michel, 2022, The type specimens of extant asteroids (Echinodermata) in the Muséum national d'Histoire naturelle of Paris, pp. 259-334 in Zoosystema 44 (11) on page 320, DOI: 10.5252/zoosystema2022v44a11, http://zenodo.org/record/6616817
A Convexity Criterion for Unique Ergodicity of Interval Exchange Transformations
Creators: name: Rühr, Rene
Publisher: name: arXiv
Year: 2019
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: A criterion for unique ergodicity for points of a curve in the space of interval exchange transformation is given.
Additional file 9 of Isolation and characterisation of ΦcrAss002, a crAss-like phage from the human gut that infects Bacteroides xylanisolvens
Creators: name: Guerin, Emma
name: Shkoporov, Andrey N.
name: Stockdale, Stephen R.
name: Comas, Joan Colom
name: Khokhlova, Ekaterina V.
name: Clooney, Adam G.
name: Daly, Karen M.
name: Draper, Lorraine A.
name: Stephens, Niamh
name: Scholz, Dimitri
name: R. Paul Ross
name: Hill, Colin
Publisher: name: figshare
Year: 2021
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional file 8: Figure S5. Transmission electron micrographs showing vesicle-like structures on the surface of B. xylanisolvens APCS1/XY cells. Micrographs were prepared from cross-sections of soft agar collected lawns of B. xylanisolvens APCS1/XY with and without spotting of ΦcrAss002 lysates.
title: 03_0554
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Investigation into thermal adaptation mechanisms of Streptococcus pneumoniae and its impact on pneumococcal pathogenicity
Creators: name: Ozcan Gazioglu
Publisher: name: University of Leicester
Year: 2020
Subjects: Uncategorized

description: Temperature is a critical and ubiquitous environmental signal that influences the growth, virulence, and survival of diverse microbial species. The human pathogen Streptococcus pneumoniae is a commensal microorganism, whose ecological niche is the human nasopharynx, and becomes pathogenic after spreading to other niches such as lung, blood stream, or brain. During progression from colonisation to invasion, the pneumococcus must contend with temperature fluctuations that can influence its phenotypic character. This study demonstrated that temperature has a significant impact on pneumococcal phenotype, such as growth, biofilm formation, metabolism, and virulence factor generation. To understand the thermal adaptation mechanisms employed by this microbe, the pneumococcal transcriptome was obtained by microarray analysis at 34°C, 37°C, or 40°C. The analysis showed that 6% (132) and 5% (120) of genes were differentially expressed at 34ºC and 40ºC, respectively, at mid-exponential growth phase by 2-fold relative to the expression at 37ºC. Interestingly, the genes upregulated in one temperature were downregulated at another temperature. For further analysis, I selected seven genes (gdhA, ciaR, comD, merR2, SPD_0132/0133, SPD_1711, and SPD_1651) that were expressed differentially at different temperatures and characterized the mutants using different experimental techniques such as growth profile analysis, cell size measurement, biofilm formation, capsule synthesis, and for the production of virulence proteins. I found that loss of the selected genes led to attenuation at 40°C in all assays comparing to the wild type strain. It was particularly interesting to find that glutamate dehydrogenase (gdhA, SPD_1158) is highly active at 40°C rather than 34°C, suggesting that GdhA is a thermostable protein. In vivo analysis showed that gdhA-null strain grown at 40°C was less virulent in G. mellonella acute infection model, indicating that GdhA is required for pneumococcal virulence at high temperatures. In conclusion, temperature fluctuation has impact on transcriptional and phenotypic profiles of S. pneumoniae.
Global hyperbolicity and factorization in cosmological models
Creators: name: Avetisyan, Zhirayr
Publisher: name: arXiv
Year: 2020
Subjects: subject: Mathematical Physics (math-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences
subject: 53Z05, 57R22, 58J32

description: The subject of the paper is the geometry and topology of cosmological spacetimes and vector bundles thereon, which are used to model physical fields propagating in the universe. Global hyperbolicity and factorization properties of the spacetime and the vector bundle that are usually independently assumed to hold, are now derived from a minimal set of assumptions based on the recent progress in differential geometry and topology.
description: Revised in accordance with the referee's suggestions
Two thymol derivatives from the flower buds of Lonicera japonica and their antibacterial activity
Creators: name: Yang, Jing
name: Li, Yong-Chao
name: Zhou, Xiu-Ren
name: Xu, Xin-Juan
name: Fu, Qing-Yun
name: Liu, Chang-Zhong
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Virology

description: A new monoterpenoid, 7-acetyl-8,9-dihydroxy thymol (1), together with a known one 7,8-dihydroxy-9-buyryl thymol (2), were isolated from the dried flower buds of Lonicera japonica Thunb. Their structures were elucidated on the basis of extensive 1D and 2D NMR spectroscopic data analyses. The potential antibacterial effects of these compounds on Staphylococcus aureus, Escherichia coli, Micrococcus luteus, and Bacillus cereus were evaluated. Interestingly, both compounds 1 and 2 exhibited significant antibacterial activities with IC50 values range from 27.64 ± 2.26 to 128.58 ± 13.26 μg/mL.
Nonlinear optics via double dark resonances
Creators: name: Yelin, S. F.
name: Sautenkov, V. A.
name: Kash, M. M.
name: Welch, G. R.
name: Lukin, M. D.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Double dark resonances originate from a coherent perturbation of a system displaying electromagnetically induced transparency. We experimentally show and theoretically confirm that this leads to the possibility of extremely sharp resonances prevailing even in the presence of considerable Doppler broadening. A gas of 87Rb atoms is subjected to a strong drive laser and a weak probe laser and a radio frequency field, where the magnetic coupling between the Zeeman levels leads to nonlinear generation of a comb of sidebands.
description: 6 pages, 9 figures
Reanalysis of the OGLE-I observations with the Image Subtraction Method. I. Galactic bar fields MM1-A, MM1-B, MM7-A, and MM7-B
Creators: name: Pigulski, A.
name: Kolaczkowski, Z.
name: Kopacki, G.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: As a result of the reanalysis of the OGLE-I observations by means of the image subtraction method, we present the first part of a catalog, consisting of the data for variable stars in four Galactic fields observed by the OGLE-I, viz. MM1-A, MM1-B, MM7-A, and MM7-B. In total, 2016 variable stars have been found. This increased the number of known variable in these fields stars more than twofold. We comment on the detectability of the variable stars in previous studies. Some interesting findings are also discussed. Among others, we found 45 Delta Scuti stars (38 are new) including several multiperiodic objects. Detailed analysis of the light curves of 47 RR Lyrae stars (24 are new detections) allowed us to find five stars which exhibit nonradial pulsations and one RRd star. Three RRab stars are members of the Sagittarius dwarf galaxy (Sgr dSph). We also find four objects which are probably galactic RV Tauri stars and one W Virginis star which seems to belong to Sgr dSph. This is the first Population II Cepheid found in this satellite galaxy and dSph other than the Fornax one. For eclipsing EW-type binaries, which are the most abundant variables in our catalog, we investigate the amplitude and period distributions. A comparison with the previous OGLE-I catalogs indicates that we found more stars with smaller amplitudes. Finally, in addition to the two microlensing events discovered previously in these fields, we find five more.
description: 19 pages, 9 figures, accepted by the Acta Astronomica
Additional file 3 of Na+/Ca2+ exchanger isoform 1 takes part to the Ca2+-related prosurvival pathway of SOD1 in primary motor neurons exposed to beta-methylamino-l-alanine
Creators: name: Petrozziello, Tiziana
name: Boscia, Francesca
name: Tedeschi, Valentina
name: Pannaccione, Anna
name: de Rosa, Valeria
name: Corvino, Angela
name: Severino, Beatrice
name: Annunziato, Lucio
name: Secondo, Agnese
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Plant Biology

description: Additional file 2. (A) Bar graph depicting the effect of Chemical Hypoxia on cell survival of differentiated NSC-34 cells pretreated (10 min) with 40, 400 or 4000 ng/ml SOD1. Data are expressed as mean±S.E. of three different experimental sessions. *p<0.05 versus control; **p<0.05 versus Chemical Hypoxia alone and ***p<0.05 versus All. (B) DCF-DA-detected ROS production in differentiated NSC-34 cells exposed to Chemical Hypoxia or Chemical Hypoxia plus SOD1 (400 ng/ml). Data are expressed as mean±S.E. of three different experiments. *p<0.05 versus control; **p<0.05 versus Chemical Hypoxia alone. (C) Bar graph depicting the effect of Chemical Hypoxia on cell survival of differentiated NSC-34 motor neurons transfected with siMEK1 (10 nM) or treated with PD98059, or Akt D− (2 μg/μl) or treated with LY294002 and then exposed to SOD1 (400 ng/ml/10 min). Data are expressed as mean±S.E. of three different experimental sessions. *p<0.05 versus control alone; **p<0.05 versus Chemical Hypoxia alone; ***p<0.05 versus Chemical Hypoxia +SOD1.
Mosque-Based Health Literacy Sessions with Immigrant Seniors
Creators: Salma, Jordana
Layton, Mahenaz
Au, Alesia
Thennakoonwela, Pram
Temuri, Huda
Publisher: name: University of Alberta Library
Year: 2024

This report describes a project conducted by the University of Alberta's Faculty of Nursing in partnership with the Muslim Association of Canada (MAC) at Edmonton Rahma Mosque, which sought to address health disparities by providing culturally tailored health education sessions in Urdu and Arabic. Covering fall prevention, dementia awareness, urinary incontinence management, nutrition, mental health, hygiene, and physical activity, these sessions aimed to empower immigrant seniors to make informed decisions about their health. Participants reported high relevance, comprehension, and satisfaction, emphasizing the value of interactive, translated, and culturally sensitive information. Continuous improvements in finding culturally sensitive health education material, translating sessions more effectively, and increasing the number of topics the program covers, were highlighted as crucial for future health education initiatives for immigrant seniors.
Comment on "Dense coding in entangled states"
Creators: name: Akhavan, O.
name: Rezakhani, A. T.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In a recent Brief Report, Lee et al. [L. Lee, D. Ahn, and S.W. Hwang, Phys. Rev. A 66, 024304 (2002)] have claimed that using pairwise entangled qubits gives rise to an exponentially more efficient dense coding when two parties are involved than using maximally entangled qubits shared among N parties. Here, we show that their claim is not true.
description: 1 page, no figure, revtex