cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Angiotensin II stimulates protein-tyrosine phosphorylation in a calcium-dependent manner.
Creators: name: Herman, B
name: Huckle, W R
name: Dy, R C
name: Prokop, C A
name: Earp, S
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: Cellular responses to epidermal growth factor (EGF) are dependent on the tyrosine-specific protein kinase activity of the cell-surface EGF receptor. Previous studies using WB rat liver epithelial cells have detected at least 10 proteins whose phosphotyrosine (P-Tyr) content is increased by EGF. In this study, we have examined alternate modes of activating tyrosine phosphorylation. Treatment of WB cells with hormones linked to Ca2+ mobilization and protein kinase C (PKC) activation, including angiotensin II, [Arg8]vasopressin, or epinephrine, stimulated rapid (less than or equal to 15-s) and transient increases in the P-Tyr content of several proteins (p120/125, p75/78, and p66). These proteins, detected by anti-P-Tyr immunoblotting, were similar in molecular weight to a subset of EGF-sensitive P-Tyr-containing proteins (P-Tyr-proteins). The increased P-Tyr content was confirmed by [32P]phosphoamino acid analysis of proteins recovered by anti-P-Tyr immunoprecipitation. Elevating intracellular [Ca2+] with the ionophore A23187 or ionomycin or with the tumor promoter thapsigargin mimicked the effects of hormones on tyrosine phosphorylation, whereas treatment with a PKC-activating phorbol ester did not. In addition, responses to angiotensin II were not diminished in PKC-depleted cells. Ca2+ mobilization, measured by fura-2 fluorescence, was coincident with the increase in tyrosine phosphorylation in response to angiotensin II or thapsigargin. Loading cells with the intracellular Ca2+ chelator bis-(o-aminophenoxy)ethane-N ,N ,N' , N'-tetraacetic acid (BAPTA) inhibited the appearance of all P-Tyr-proteins in response to angiotensin II, thapsigargin, or ionophores, as well as two EGF-stimulated P-Tyr-proteins. The majority of EGF-stimulated P-Tyr-proteins were not affected by BAPTA. These studies indicate that angiotensin II can alter protein-tyrosine phosphorylation in a manner that is secondary to, and apparently dependent on, Ca2+ mobilization. Thus, ligands such as EGF and angiotensin II, which act through distinct types of receptors, may activate secondary pathways involving tyrosine phosphorylation. These results also raise the possibility that certain growth-promoting effects of Ca2+ -mobilizing agents such as angiotensin II may be mediated via tyrosine phosphorylation.
Online Lifelong Generalized Zero-Shot Learning
Creators: name: Gautam, Chandan
name: Parameswaran, Sethupathy
name: Mishra, Ashish
name: Sundaram, Suresh
Publisher: name: arXiv
Year: 2021
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Methods proposed in the literature for zero-shot learning (ZSL) are typically suitable for offline learning and cannot continually learn from sequential streaming data. The sequential data comes in the form of tasks during training. Recently, a few attempts have been made to handle this issue and develop continual ZSL (CZSL) methods. However, these CZSL methods require clear task-boundary information between the tasks during training, which is not practically possible. This paper proposes a task-free (i.e., task-agnostic) CZSL method, which does not require any task information during continual learning. The proposed task-free CZSL method employs a variational autoencoder (VAE) for performing ZSL. To develop the CZSL method, we combine the concept of experience replay with knowledge distillation and regularization. Here, knowledge distillation is performed using the training sample's dark knowledge, which essentially helps overcome the catastrophic forgetting issue. Further, it is enabled for task-free learning using short-term memory. Finally, a classifier is trained on the synthetic features generated at the latent space of the VAE. Moreover, the experiments are conducted in a challenging and practical ZSL setup, i.e., generalized ZSL (GZSL). These experiments are conducted for two kinds of single-head continual learning settings: (i) mild setting-: task-boundary is known only during training but not during testing; (ii) strict setting-: task-boundary is not known at training, as well as testing. Experimental results on five benchmark datasets exhibit the validity of the approach for CZSL.
Characterization of the rat transforming growth factor alpha gene and identification of promoter sequences.
Creators: name: Lee, D C
name: Chen, X R
name: Rogers, K T
name: Blasband, A J
name: Azizkhan, J C
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: We have determined the complete nucleotide sequence of rat transforming growth factor alpha (TGF alpha) mRNA and characterized the six exons that encode this transcript. These six exons span approximately 85 kilobases of genomic DNA, with exons 1 to 3 separated by particularly large introns. What had previously been thought to represent a species-specific difference in the size of the TGF alpha precursor (proTGF alpha) is now shown to be due to microheterogeneity in the splicing of exons 2 and 3. This results from a tandem duplication of the acceptor CAG and gives rise to two alternate forms (159 and 160 amino acids) of the integral membrane precursor. Exon 6, which encodes the 3' untranslated region of TGF alpha mRNA, also encodes, on the opposite strand, a small (approximately 200-nucleotide) transcript whose sequence predicts an open reading frame of 51 amino acids. Expression of this latter transcript does not appear to be coregulated with that of TGF alpha mRNA. Primer extension and S1 nuclease analyses of authentic TGF alpha transcripts revealed two major and multiple minor 5' ends which span more than 200 base pairs of DNA in a G + C-rich region that lacks canonical CCAAT or TATA sequences. The 5' ends of six independently derived cDNAs localized to five different sites in this same region. Restriction fragments that overlap these transcription start sites and extend approximately 300 base pairs in the 5' direction faithfully promote transcription in vitro with HeLa cell nuclear extracts. In addition, they direct the expression of the bacterial chloramphenicol acetyltransferase gene in transient-transfection assays.
L'accompagnement de l'adulte polyhandicapé en fin de vie
Creators: name: Vulliemin, Estelle
Publisher: name: Unknown
Year: 0
Subjects: subject: polyhandicapé
subject: fin de vie
subject: mort
subject: accompagnement
subject: soins palliatifs
subject: soins holistiques

description: Cette recherche qualitative de type exploratoire a pour cadre de référence des notions générales telles que l’accompagnement , les soins palliatifs et le polyhandicap. Des entretiens semi-structurés ont été menés auprès de trois infirmières travaillant dans deux institutions de Suisse romande accueillant des adultes polyhandicapés. Le but des entretiens était de mettre en évidence et de décrire la pratique des soignants qui accompagnent ces personnes lors des derniers jours de leur vie, et ainsi de répondre à la question de recherche. La méthode d’interprétation des résultats est une analyse de contenu.
description: Mémoire de fin d'études ; volée automne 02
Giant and tunneling magnetoresistance effects from anisotropic and valley-dependent spin-momentum interactions in antiferromagnets
Creators: name: Šmejkal, Libor
name: Hellenes, Anna Birk
name: González-Hernández, Rafael
name: Sinova, Jairo
name: Jungwirth, Tomáš
Publisher: name: arXiv
Year: 2021
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Giant or tunneling magnetoresistance are physical phenomena used for reading information in commercial spintronic devices. The effects rely on a conserved spin current passing between a reference and a sensing ferromagnetic electrode in a multilayer structure. Recently, we have proposed that these fundamental spintronic effects can be realized in collinear antiferromagnets with staggered spin-momentum exchange interaction, which generates conserved spin currents in the absence of a net equilibrium magnetization. Here we elaborate on the proposal by presenting archetype model mechanisms for the antiferromagnetic giant and tunneling magnetoresistance effects. The models are based, respectively, on anisotropic and valley-dependent forms of the non-relativistic staggered spin-momentum interaction. Using first principles calculations we link these model mechanisms to real antiferromagnetic materials and predict a $\sim$100\% scale for the effects. We point out that besides the GMR/TMR detection, our models directly imply the possibility of spin-transfer-torques excitation of the antiferromagnets.
description: 6 pages, 4 figures
Characterization of the S-phase-specific transcription regulatory elements in a DNA replication-independent testis-specific H2B (TH2B) histone gene.
Creators: name: Hwang, I W
name: Lim, K
name: Chae, C B
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: The testis-specific H2B histone (TH2B) gene is expressed in pachytene spermatocytes of meiotic prophase I during rat spermatogenesis. The TH2B RNA and histones are not synthesized in any other tissues, and the synthesis is independent of DNA replication. However, the cloned TH2B gene has two DNA sequence elements which stimulate transcription of the cloned gene in an S-phase-dependent manner when introduced into somatic cells. The factors interacting with the two elements, CCAAT at -127 base pairs and octamer ATTTGCAT at -93 base pairs, interact with each other to bring about a maximum stimulation of S-phase-dependent transcription. The level of CCAAT and octamer-binding proteins is unchanged during the cell cycle, and the S-phase-dependent transcription of TH2B and endogenous mouse H2B genes does not require synthesis of new proteins during the S phase. Cell cycle-specific posttranslational modification of regulatory proteins may be responsible for the S-phase-dependent transcription of H2B histone genes. The biological significance of the presence of S-phase-specific transcription regulatory elements in the DNA replication-independent and tissue-specific TH2B gene is not known.
Feathering Instability of Spiral Arms. II. Parameter Study
Creators: name: Lee, Wing-Kit
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We report the results of a parameter study of the feathering stability in the galactic spiral arms. A two-dimensional razor-thin magnetized self-gravitating gas disk with an imposed two-armed stellar spiral structure is considered. Using the formulation developed previously by Lee and Shu, a linear stability analysis of the spiral shock is performed in a localized Cartesian geometry. Results of the parameter study of the base state with a spiral shock are also presented. The single-mode feathering instability that leads to growing perturbations may explain the feathering phenomenon found in nearby spiral galaxies. The self-gravity of the gas, characterized by its average surface density, is an important parameter which 1) shifts the spiral shock further downstream; 2) increases the growth rate and decreases the characteristic spacing of the feathering structure due to the instability. On the other hand, while the magnetic field suppresses the velocity fluctuation associated with the feathers, it does not strongly affect their growth rate. Using a set of typical parameters of the grand-design spiral galaxy M51 at 2 kpc from the center, the spacing of the feathers with the maximum growth rate is found to be 530 pc, which agrees with the previous observational studies.
description: 18 pages, 18 figures. Accepted for publication in ApJ
The inverse scattering of the Zakharov-Shabat system solves the weak noise theory of the Kardar-Parisi-Zhang equation
Creators: name: Krajenbrink, Alexandre
name: Doussal, Pierre Le
Publisher: name: arXiv
Year: 2021
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Mathematical Physics (math-ph)
subject: Dynamical Systems (math.DS)
subject: Probability (math.PR)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We solve the large deviations of the Kardar-Parisi-Zhang (KPZ) equation in one dimension at short time by introducing an approach which combines field theoretical, probabilistic and integrable techniques. We expand the program of the weak noise theory, which maps the large deviations onto a non-linear hydrodynamic problem, and unveil its complete solvability through a connection to the integrability of the Zakharov-Shabat system. Exact solutions, depending on the initial condition of the KPZ equation, are obtained using the inverse scattering method and a Fredholm determinant framework recently developed. These results, explicit in the case of the droplet geometry, open the path to obtain the complete large deviations for general initial conditions.
description: 35 pages - V3 Some details of the derivation of the general solution to the P,Q system have been added in Section S-E
Expression of the yeast PHR1 gene is induced by DNA-damaging agents.
Creators: name: Sancar, G B
name: Kraus, B
name: Sebastian, J
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: The PHR1 gene of Saccharomyces cerevisiae encodes a photolyase which repairs specifically and exclusively pyrimidine dimers, the most frequent lesions induced in DNA by far-UV radiation. We have asked whether expression of PHR1 is modulated in response to UV-induced DNA damage and to DNA-damaging agents that induce lesions structurally dissimilar to pyrimidine dimers. Using a PHR1-lacZ fusion gene in which expression of beta-galactosidase is regulated by PHR1 5' regulatory elements, we found that exposure of cells to 254-nm light, 4-nitroquinoline-N-oxide, methyl methanesulfonate, and N-methyl-N'-nitro-N-nitrosoguanidine induced synthesis of increased amounts of fusion protein. In contrast to these DNA-damaging agents, neither heat shock nor exposure to photoreactivating light elicited a response. Induction by far-UV radiation was evident both when the fusion gene was carried on a multicopy plasmid and when it replaced the endogenous chromosomal copy of PHR1, and it was accompanied by an increase in the steady-state concentration of PHR1-lacZ mRNA. Northern (RNA) blot analysis of PHR1 mRNA encoded by the chromosomal locus was consistent with either enhanced transcription of PHR1 after DNA damage or stabilization of the transcripts. Neither the intact PHR1 or RAD2 gene was required for induction. Comparison of the region of PHR1 implicated in regulation of its expression with other damage-inducible genes from yeast cells revealed a common conserved sequence that is present in the PHR1, RAD2, and RNR2 genes and is required for damage inducibility of the latter two genes. These sequences may constitute elements of a damage-responsive regulon in S. cerevisiae.
The inverse mean curvature flow perpendicular to the sphere
Creators: name: Lambert, Ben
name: Scheuer, Julian
Publisher: name: arXiv
Year: 2014
Subjects: subject: Differential Geometry (math.DG)
subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: We consider the smooth inverse mean curvature flow of strictly convex hypersurfaces with boundary embedded in $\mathbb{R}^{n+1},$ which are perpendicular to the unit sphere from the inside. We prove that the flow hypersurfaces converge to the embedding of a flat disk in the norm of $C^{1,β},$ $β<1.$
description: 18 pages. Comments or suggestions are welcome
Consequences of chirally enhanced explanations of $(g-2)_μ$ for $h\to μμ$ and $Z\to μμ$
Creators: name: Crivellin, Andreas
name: Hoferichter, Martin
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: With the long-standing tension between experiment and Standard-Model (SM) prediction in the anomalous magnetic moment of the muon $a_μ$ recently reaffirmed by the Fermilab experiment, the crucial question becomes which other observables could be sensitive to the underlying physics beyond the SM to which $a_μ$ may be pointing. While from the effective field theory (EFT) point of view no direct correlations exist, this changes in specific new physics models. In particular, in the case of explanations involving heavy new particles above the electroweak (EW) scale with chiral enhancement, which are preferred to evade exclusion limits from direct searches, correlations with other observables sensitive to EW symmetry breaking are expected. Such scenarios can be classified according to the $SU(2)_L$ representations and the hypercharges of the new particles. We match the resulting class of models with heavy new scalars and fermions onto SMEFT and study the resulting correlations with $h\toμμ$ and $Z\toμμ$ decays, where, via $SU(2)_L$ symmetry, the latter process is related to $Z\toνν$ and modified $W$-$μ$-$ν$ couplings.
description: 19 pages, 3 figures; $SU(2)_L$ factors corrected
Supplementary Material for 'Hybrid social learning in human-algorithm cultural transmission'
Creators: name: Brinkmann, L.
name: Gezerli, D.
name: Kleist, K. V.
name: Müller, T. F.
name: Rahwan, I.
name: Pescetelli, N.
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences
subject: 80399 Computer Software not elsewhere classified
subject: 120304 Digital and Interaction Design
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: Supplementary methods, tables and figures.
Functional analysis of c-Myb protein in T-lymphocytic cell lines shows that it trans-activates the c-myc promoter.
Creators: name: Moore, T L
name: Bender, T
name: Ting, J P
name: Kuehl, W M
name: Evans, J L
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: The function of c-Myb protein was revealed by transfecting an expression vector containing the entire c-Myb protein-coding sequence into the murine CTLL-2 T-cell line. Expressions of high levels of c-Myb protein did not alter the expression of several T-cell markers, c-fos mRNA expression, responses to interleukin-2, and growth characteristics of these cells. Interestingly, expression of the c-myc gene was drastically increased in this clone. Further, the c-myb expression plasmid, but not a frameshift mutant of c-myb, enhanced the expression of a hybrid construct of c-myc promoter linked to a reporter gene by 8- to 14-fold. These results demonstrate a role of c-Myb protein in c-myc gene expression.
Le soignant à la rencontre du patient en pleurs
Creators: name: De Mooij, Myriam
Publisher: name: Unknown
Year: 0
Subjects: subject: relation soignant-soigné
subject: émotion
subject: empathie

description: Cette recherche de type exploratoire porte sur la question de la rencontre du soignant avec un patient en pleurs, dans une perspective phénoménologique. Cette étude vise à explorer les comportements des soignants face à une personne soignée en pleurs ainsi que les attentes des patients à leur égard. Les réactions les plus fréquentes des infirmiers sont présentées ainsi que leurs ressentis, tout en les comparant aux attentes des patients. Les représentations tant des soignants que des soignés sur le sujet ainsi que les facteurs favorisant l’expression des pleurs transparaissent également dans ce travail. L’offre infirmière, les attentes des patients ainsi que leurs représentations sont comparées tout au long de l’analyse thématique.
description: Mémoire de fin d'études volée Automne 02
GIRL IN THE YELLOW DRESS
Creators: name: Scraggs, Mary
Publisher: name: University of Mmassachusetts Amherst
Year: 2022

description:
ABSTRACT


GIRL IN THE YELLOW DRESS


MAY 2022


MARY KATE SCRAGGS, B.A. UNIVERSITY OF COLORADO BOULDER


M.F.A. UNIVERSITY OF MASSACHUSETTS AMHERST


Directed by: Professor Dara Wier


Mary Kate Scraggs’s collection of poetry aims for both stillness and exploration as she uncovers a memory landscape that is intimate, faraway, strange, and fleeting. Her poems tackle themes of time, memory, illness, grief, and love while slipping in and out of what is real and what is mystical, both formally and conceptually, the breath ever-present and aware of its humanness, of its desire to wander.
L'écart entre les caratéristiques de la formation HES et les attentes des infirmiers sur la formation professionnelle
Creators: name: Scaramozzino, Frédéric
Publisher: name: Unknown
Year: 0
Subjects: subject: formation infirmière
subject: formation professionnelle
subject: haute école spécialisée

description: Le but de cette recherche est d'identifier les éléments porteurs de sens de l'écart entre la formation HES et la réalité du travail sur le terrain. Ainsi, une formation trop théorique par un nombre de stages réduit, une entrée au niveau tertiaire universitaire comme l'adéquation à la " réalité du terrain ", étaient des éléments discutables aux yeux des infirmiers dans la réforme des études. Le référentiel des neufs compétences HES, a fait l'objet de remarques similaires car perçu comme incompréhensible, inadapté et difficile à transposer au quotidien des soins. Sans aucun doute, ces remarques sont les indices d'un écart entre les caractéristiques de la formation infirmière HES et la vision des soignants sur ce qu'ils pensent être le mieux adapté à la réalité du terrain, en terme de formation des professionnels L'étude se base sur des concepts tels que les rapports théorie-pratique, les rapports école-stage ainsi que la notion de résistance au changement. Elle est menée au moyen d'entretiens semi-structurés, auprès de quatre soignants diplômés niveau II, exerçant leur activité dans un centre hospitalier vaudois.
description: Mémoire de fin d'études ; volée automne 02
Hands Clutching Temples
Creators: name: Brown, Sarena
Publisher: name: University of Mmassachusetts Amherst
Year: 2022

description:
A collection of found poems using the Edwardian text “Peter Pan in Kensington Gardens” by J.M. Barrie. This thesis explores themes of gender, mental health, and queer belonging while theorizing about the materiality of poetry.
Meiotic recombination between dispersed repeated genes is associated with heteroduplex formation.
Creators: name: Petes, T D
name: Nag, D K
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: In Saccharomyces cerevisiae, recombination events occurring between allelic genes located on homologous chromosomes are often associated with heteroduplex formation. We found that recombination events between repeated genes on nonhomologous chromosomes (ectopic events) are also associated with the formation of heteroduplexes, indicating that classical and ectopic recombination events involve similar mechanisms.
Hadronic light-by-light contribution to the muon $g-2$ from holographic QCD with solved $U(1)_A$ problem
Creators: name: Leutgeb, Josef
name: Mager, Jonas
name: Rebhan, Anton
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We employ the comparatively minimal extension of hard-wall AdS/QCD due to Katz and Schwartz which takes into account the U(1)$_A$ anomaly for computing hadronic light-by-light scattering contributions of pseudoscalar and axial vector mesons to the anomalous magnetic moment of the muon $a_μ$. By including a gluon condensate as one extra tunable parameter besides those fixed by $f_π$ and the pion, kaon, and rho masses, we obtain remarkably accurate fits for $η$ and $η'$ masses and their decay rates to photons, leading to $a_μ$ contributions in complete agreement with the Standard Model result by the Muon $g-2$ Theory Initiative. Turning to the less well understood axial vector contributions, we update our previous predictions obtained in flavor-symmetric hard-wall AdS/QCD models without U(1)$_A$ breaking.
description: REVTEX, 13 pages, 4 figures, 4 tables; v2: slight extensions and updates of numerical results, minor additions, references added
Band Gaps and Optical Spectra from Single- and Double-Layer Fluorographene to Graphite Fluoride: Many-Body Effects and Excitonic States
Creators: name: Karlický, František
name: Otyepka, Michal
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We compare first-principle band gaps and optical absorption spectra of single- and double-layer fluorographene with bulk graphite fluoride. The electronic properties are calculated using the many-body GW approximation and the optical spectra using the Bethe-Salpeter equation (BSE). The inclusion of electron-hole interactions is crucial for predicting low energy excitonic absorption peaks. The position of the first exciton peak is identical in single-, double- and multilayer fluorographene, which may indicate that the onset of the absorption spectra does not differ in these materials.
Bathtub Mary
Creators: name: Marshall, Laura S
Publisher: name: University of Mmassachusetts Amherst
Year: 2022

description:
As a poet, I am continually on the lookout for the strange in the real, and the real in the strange: scientific, linguistic, poetic, human. These poems are my offerings of strange realness and real strangeness. Often where the poems want to go is toward questions that live in connection / disconnection, identity, disability and illness, art, religion and ritual, desire and love and wanting, and one of my dearest loves, music. And, of course, science and language, and the language of science.
Methods of Continuation and their Implementation in the COCO Software Platform with Application to Delay Differential Equations
Creators: name: Ahsan, Zaid
name: Dankowicz, Harry
name: Li, Mingwu
name: Sieber, Jan
Publisher: name: arXiv
Year: 2021
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: This paper treats comprehensively the construction of problems from nonlinear dynamics and constrained optimization amenable to parameter continuation techniques and with particular emphasis on multi-segment boundary-value problems with delay. The discussion is grounded in the context of the COCO software package and its explicit support for community-driven development. To this end, the paper first formalizes the COCO construction paradigm for augmented continuation problems compatible with simultaneous analysis of implicitly defined manifolds of solutions to nonlinear equations and the corresponding adjoint variables associated with optimization of scalar objective functions along such manifolds. The paper uses applications to data assimilation from finite time histories and phase response analysis of periodic orbits to identify a universal paradigm of construction that permits abstraction and generalization. It then details the theoretical framework for a COCO-compatible toolbox able to support the analysis of a large family of delay-coupled multi-segment boundary-value problems, including periodic orbits, quasiperiodic orbits, connecting orbits, initial-value problems, and optimal control problems, as illustrated in a suite of numerical examples. The paper aims to present a pedagogical treatment that is accessible to the novice and inspiring to the expert by appealing to the many senses of the applied nonlinear dynamicist. Sprinkled among a systematic discussion of problem construction, graph representations of delay-coupled problems, and vectorized formulas for problem discretization, the paper includes an original derivation using Lagrangian sensitivity analysis of phase-response functionals for periodic-orbit problems in abstract Banach spaces, as well as a demonstration of the regularizing benefits of multi-dimensional manifold continuation for near-singular problems.
Nucleosome depletion alters the chromatin structure of Saccharomyces cerevisiae centromeres.
Creators: name: Bloom, K
name: Saunders, M J
name: Yeh, E
name: Grunstein, M
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: Saccharomyces cerevisiae centromeric DNA is packaged into a highly nuclease-resistant chromatin core of approximately 200 base pairs of DNA. The structure of the centromere in chromosome III is somewhat larger than a 160-base-pair nucleosomal core and encompasses the conserved centromere DNA elements (CDE I, II, and III). Extensive mutational analysis has revealed the sequence requirements for centromere function. Mutations affecting the segregation properties of centromeres also exhibit altered chromatin structures in vivo. Thus the structure, as delineated by nuclease digestion, correlated with functional centromeres. We have determined the contribution of histone proteins to this unique structural organization. Nucleosome depletion by repression of either histone H2B or H4 rendered the cell incapable of chromosome segregation. Histone repression resulted in increased nuclease sensitivity of centromere DNA, with up to 40% of CEN3 DNA molecules becoming accessible to nucleolytic attack. Nucleosome depletion also resulted in an alteration in the distribution of nuclease cutting sites in the DNA surrounding CEN3. These data provide the first indication that authentic nucleosomal subunits flank the centromere and suggest that nucleosomes may be the central core of the centromere itself.
Consommation de cannabis à l'hôpital : quels problèmes pour les soignants en psychiatrie ?
Creators: name: Cosma Boye, Mai
Publisher: name: Unknown
Year: 0
Subjects: subject: hôpital psychiatrie
subject: cannabis
subject: consommation
subject: rôle infirmier
subject: offre en soins
subject: recherche-action

description: En utilisant une approche méthodologique inspirée de la recherche-action, cette recherche vise, dans un premier temps, à accompagner un groupe de soignants à comprendre en quoi la consommation de cannabis par les patients hospitalisés est problématique à leurs yeux. Ensuite, il s’agit de faire des propositions visant à améliorer la situation actuelle des soignants et à concevoir des interventions adaptées aux besoins spécifiques de ces patients. La première phase de la recherche a constitué en des entretiens individuels avec dix soignants, en utilisant une trame semi-directive. L’offre en soins, les connaissances scientifiques, la santé des patients, le cadre institutionnel et le rôle du soignant sont étudiés. Ensuite, dans une seconde phase, et au sein d’un focus group composé de cinq soignants, le pôle des connaissances scientifiques a été choisi comme la première intervention à mettre en place dans l’institution, afin d’initier le changement.
description: Mémoire de fin d'études volée Automne 02
(:unas) unassigned
Creators: name: (:Unkn) Unknown
Publisher: name: Universita' degli Studi di Salerno
Year: 2024

description: Studio di fattibilità d’una riduzione di Poema a fumetti a testo drammatico e sua messa in scena (2015). Parola e immagine sono in Buzzati facce di una medesima vocazione narrativa, egli ha già drammatizzato tre sue novelle e per lui teatro è fusione tra forme espressive diverse. Emularne abbandono del naturalismo, soluzioni “narrative”, aggiunta di personaggi, rottura e complicazione di finzione temporale può ben veicolare in scena il messaggio dell’opera grafico-testuale.
description: An essay on Poema a fumetti’s convertibility into a dramatic text and its mise-en-scène (2015). Word and image in Buzzati are faces of a same narrative vocation. He has already adapted three of his short stories into plays. Theater is for him a fusion between different expressive forms. The emulation of his abandonment of naturalism, “narrative” solutions, addition of characters, breakup and complication of the temporal fiction can convey on stage the message of the graphictextual work.
Nitrogen as a Tracer of Giant Planet Formation. I.: A Universal Deep Adiabatic Profile and Semi-analytical Predictions of Disequilibrium Ammonia Abundances in Warm Exoplanetary Atmospheres
Creators: name: Ohno, Kazumasa
name: Fortney, Jonathan J.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: A major motivation of spectroscopic observations of giant exoplanets is to unveil planet formation processes from atmospheric compositions. Several recent studies suggested that atmospheric nitrogen, like carbon and oxygen, can provide important constrains on planetary formation environments. Since nitrogen chemistry can be far from thermochemical equilibrium in warm atmospheres, we extensively investigate under what conditions, and with what assumptions, the observable NH3 abundances can diagnose an atmosphere's bulk nitrogen abundance. In the first paper of this series, we investigate atmospheric T-P profiles across equilibrium temperature, surface gravity, intrinsic temperature, atmospheric metallicity, and C/O ratio using a 1D radiative-convective equilibrium model. Models with the same intrinsic temperature and surface gravity coincide with a shared "universal" adiabat in the deep atmosphere, across a wide equilibrium temperature range (250--1200 K), which is not seen in hotter or cooler models. We explain this behavior in terms of the classic "radiative zero solution" and then establish a semi-analytical T-P profile of the deep atmospheres of warm exoplanets. This profile is then used to predict vertically quenched NH3 abundances. At solar metallicity, our results show that the quenched NH3 abundance only coincides with the bulk nitrogen abundance (within 10%) at low intrinsic temperature, corresponding to a planet with a sub-Jupiter mass (< 1 MJ) and old age (> 1 Gyr). If a planet has a high metallicity ($\ge$ 10$\times$ solar) atmosphere, the quenched NH3 abundance significantly underestimates the bulk nitrogen abundance at almost all planetary masses and ages. We suggest modeling and observational strategies to improve the assessment of bulk nitrogen from NH3.
description: 16 pages, 5 figures, resubmitted to AAS Journal after addressing the first referee report
The ANITA Anomalous Events and Axion Quark Nuggets
Creators: name: Liang, Xunyu
name: Zhitnitsky, Ariel
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: The Antarctic Impulse Transient Antenna (\textsc{ANITA}) collaboration [1-3] has reported two anomalous events with noninverted polarity. These events are hard to explain in terms of conventional cosmic rays (CRs). We explore a new possible explanation for these anomalous events by suggesting that these events can be related to the dark matter (DM) annihilations within the so-called axion quark nugget (AQN) DM model. This model was initially invented for a completely different purpose to explain the observed similarity between the dark and the visible components in the Universe, i.e. $Ω_{\rm DM}\sim Ω_{\rm visible}$ without any fitting parameters. We investigate the signal properties of the upward-going AQN events, including the event rate, the pulse duration, and the electric field strength, and find them consistent with the observations. We list several features of the upward-going AQN events distinct from conventional CR air showers. The observations (or nonobservation) of these features may substantiate (or refute) our proposal.
description: Final version to appear in Phys Rev. D. New additional comments, including Pierre Auger constraint on upward going showers
Structure and transcription of the Drosophila melanogaster vermilion gene and several mutant alleles.
Creators: name: Ali, A J
name: Pret, A M
name: Fridell, R A
name: Ruth, R S
name: Searles, L L
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: The nucleotide sequence and intron-exon structure of the Drosophila melanogaster vermilion (v) gene have been determined. In addition, the sites of several mutations and the effects of these mutations on transcription have been examined. The major v mRNA is generated upon splicing six exons of lengths (5' to 3') 83, 161, 134, 607, 94, and 227 nucleotides (nt). A minor species of v mRNA is initiated at an upstream site and has a 5' exon of at least 152 nt which overlaps the region included in the 83-nt exon of the major v RNA. The three v mutations, v1, v2, and vk, which can be suppressed by mutations at suppressor of sable, su(s), are insertions of transposon 412 at the same position in exon 1, 36 nt downstream of the major transcription initiation site. Despite the 7.5-kilobase insertion in these v alleles, a reduced level of wild-type-sized mRNA accumulates in suppressed mutant strains. The structure and transcription of several unsuppressible v alleles have also been examined. The v36f mutation is a B104/roo insertion in intron 4 near the splice donor site. A mutant carrying this alteration accumulates a very low level of mRNA that is apparently polyadenylated at a site within the B104/roo transposon. The v48a mutation, which deletes approximately 200 nt of DNA, fuses portions of exons 3 and 4 without disruption of the translational reading frame. A smaller transcript accumulates at a wild-type level, and thus an altered, nonfunctional polypeptide is likely to be synthesized in strains carrying this mutation.(ABSTRACT TRUNCATED AT 250 WORDS)
Vortex-bound solitons in topological superfluid $^3$He
Creators: name: Mäkinen, J. T.
name: Zhang, K.
name: Eltsov, V. B.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Mathematical Physics (math-ph)
subject: Pattern Formation and Solitons (nlin.PS)
subject: FOS: Physical sciences

description: The different superfluid phases of $^3$He are described by $p$-wave order parameters that include anisotropy axes both in the orbital and spin spaces. The anisotropy axes characterize the broken symmetries in these macroscopically coherent quantum many-body systems. The systems' free energy has several degenerate minima for certain orientations of the anisotropy axes. As a result, spatial variation of the order parameter between two such regions, settled in different energy minima, forms a topological soliton. Such solitons can terminate in the bulk liquid, where the termination line forms a vortex with trapped circulation of mass and spin superfluid currents. Here we discuss possible soliton-vortex structures based on the symmetry and topology arguments and focus on the three structures observed in experiments: solitons bounded by spin-mass vortices in the B phase, solitons bounded by half-quantum vortices in the polar and polar-distorted A phases, and the composite defect formed by a half-quantum vortex, soliton and the Kibble-Lazarides-Shafi wall in the polar-distorted B phase. The observations are based on nuclear magnetic resonance (NMR) techniques and are of three types: first, solitons can form a potential well for trapped spin waves, observed as an extra peak in the NMR spectrum at shifted frequency; second, they can increase the relaxation rate of the NMR spin precession; lastly, the soliton can present the boundary conditions for the anisotropy axes in bulk, modifying the bulk NMR signal. Owing to solitons' prominent NMR signatures and the ability to manipulate their structure with external magnetic field, solitons have become an important tool for probing and controlling the structure and dynamics of superfluid $^3$He, in particular half-quantum vortices with core-bound Majorana modes.
description: 46 pages, 23 figures. Review prepared for JPCM special issue on Solitons in quantum physics
Comparison of complex Langevin and mean field methods applied to effective Polyakov line models
Creators: name: Greensite, Jeff
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: Effective Polyakov line models, derived from SU(3) gauge-matter systems at finite chemical potential, have a sign problem. In this article I solve two such models, derived from SU(3) gauge-Higgs and heavy quark theories by the relative weights method, over a range of chemical potentials where the sign problem is severe. Two values of the gauge-Higgs coupling are considered, corresponding to a heavier and a lighter scalar particle. Each model is solved via the complex Langevin method, following the approach of Aarts and James, and also by a mean field technique. It is shown that where the results of mean field and complex Langevin agree, they agree almost perfectly. Where the results of the two methods diverge, it is found that the complex Langevin evolution has a branch cut crossing problem, associated with a logarithm in the action, that was pointed out by Mollgaard and Splittorff.
description: 21 pages, 12 figures
New Bregman proximal type algorithms for solving DC optimization problems
Creators: name: Takahashi, Shota
name: Fukuda, Mituhiro
name: Tanaka, Mirai
Publisher: name: arXiv
Year: 2021
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics
subject: 90C26, 90C30, 65K05

description: Difference of Convex (DC) optimization problems have objective functions that are differences between two convex functions. Representative ways of solving these problems are the proximal DC algorithms, which require that the convex part of the objective function have $L$-smoothness. In this article, we propose the Bregman Proximal DC Algorithm (BPDCA) for solving large-scale DC optimization problems that do not possess $L$-smoothness. Instead, it requires that the convex part of the objective function has the $L$-smooth adaptable property that is exploited in Bregman proximal gradient algorithms. In addition, we propose an accelerated version, the Bregman Proximal DC Algorithm with extrapolation (BPDCAe), with a new restart scheme. We show the global convergence of the iterates generated by BPDCA(e) to a limiting critical point under the assumption of the Kurdyka-Łojasiewicz property or subanalyticity of the objective function and other weaker conditions than those of the existing methods. We applied our algorithms to phase retrieval, which can be described both as a nonconvex optimization problem and as a DC optimization problem. Numerical experiments showed that BPDCAe outperformed existing Bregman proximal-type algorithms because the DC formulation allows for larger admissible step sizes.
La fibromyalgie : facteurs favorisant l'adaptation à cet invisible persécuteur
Creators: name: Roks, Patricia
Publisher: name: Unknown
Year: 0
Subjects: subject: fibromyalgie
subject: exclusion
subject: resilience

description: L’origine ou les causes de la fibromyalgie restent inconnues aux chercheurs scientifiques. En conséquence, la prise en charge médicale ainsi que l’attitude thérapeutique à adopter face à ces patients restent vagues et insuffisantes. Les symptômes conduisent à des pertes fonctionnelles qui ont des conséquences importantes aux niveaux physique, psychologique, social et professionnel. De plus, du fait que la maladie ne soit pas objectivable ni visible, ces personnes subissent souvent le rejet de l’entourage proche ou l’exclusion socioprofessionnelle. Cette étude cherche à découvrir les facteurs qui donnent à ces personnes la force et les motivations pour combattre, s’adapter et se reconstruire. Ceci afin de pouvoir proposer, dans un deuxième temps, une attitude thérapeutique plus appropriée. Pour cette étude de type exploratoire et descriptive, c'est une méthode qualitative qui a été choisie, celle de l’entretien semi dirigé.
description: Mémoire de fin d'études ; volée automne 02
Altermagnetism: spin-momentum locked phase protected by non-relativistic symmetries
Creators: name: Šmejkal, Libor
name: Sinova, Jairo
name: Jungwirth, Tomas
Publisher: name: arXiv
Year: 2021
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The search for novel magnetic quantum phases, phenomena and functional materials has been guided by relativistic magnetic-symmetry groups in coupled spin and real space from the dawn of the field in 1950s to the modern era of topological matter. However, the magnetic groups cannot disentangle non-relativistic phases and effects, such as the recently reported unconventional spin physics in collinear antiferromagnets from the typically weak relativistic spin-orbit coupling phenomena. Here we discover that more general spin symmetries in decoupled spin and crystal space categorize non-relativistic collinear magnetism in three phases: conventional ferromagnets and antiferromagnets, and a third distinct phase combining zero net magnetization with an alternating spin-momentum locking in energy bands, which we dub "altermagnetic". For this third basic magnetic phase, which is omitted by the relativistic magnetic groups, we develop a spin-group theory describing six characteristic types of the altermagnetic spin-momentum locking. We demonstrate an extraordinary spin-splitting mechanism in altermagnetic bands originating from a local electric crystal field, which contrasts with the conventional magnetic or relativistic splitting by global magnetization or inversion asymmetry. Based on first-principles calculations, we identify altermagnetic candidates ranging from insulators and metals to a parent crystal of cuprate superconductor. Our results underpin emerging research of quantum phases and spintronics in high-temperature magnets with light elements, vanishing net magnetization, and strong spin-coherence.
description: 35 pages including Supplementary information, 8 figures, 1 table
axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase.
Creators: name: Espinosa, R
name: Frye, R A
name: O'Bryan, J P
name: Cogswell, P C
name: Le Beau, M M
name: Kitch, B
name: Earp, H S
name: Liu, E T
name: Prokop, C
name: Neubauer, A
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: Using a sensitive transfection-tumorigenicity assay, we have isolated a novel transforming gene from the DNA of two patients with chronic myelogenous leukemia. Sequence analysis indicates that the product of this gene, axl, is a receptor tyrosine kinase. Overexpression of axl cDNA in NIH 3T3 cells induces neoplastic transformation with the concomitant appearance of a 140-kDa axl tyrosine-phosphorylated protein. Expression of axl cDNA in the baculovirus system results in the expression of the appropriate recombinant protein that is recognized by antiphosphotyrosine antibodies, confirming that the axl protein is a tyrosine kinase. The juxtaposition of fibronectin type III and immunoglobulinlike repeats in the extracellular domain, as well as distinct amino acid sequences in the kinase domain, indicate that the axl protein represents a novel subclass of receptor tyrosine kinases.