cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Constructing a Lung Cancer Map of Drug Resistance States with Single-Cell Analysis
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: One of the main reasons lung cancer remains deadly, is the ability of cancer cells to acquire resistance to drug therapies and ultimately become non-responsive. This leads to eventual cancer recurrence in lung cancer patients and poor survival outcome. Understanding what helps cancer cells adjust and change during drug treatments is vital towards our efforts in preventing and counteracting the development of drug resistance. This project proposes to study mechanisms that are thought to help lung cancer cells become resistant, yet are not fully understood or used in current therapeutic strategies. Furthermore, published studies show that smoking history is correlated with the ability of lung cancer cells to avoid drug effects and become more aggressive, and this could be used to the advantage of lung cancer patients with smoking history. By using technology that will allow me to study in depth each lung cancer cell individually, will reveal the many different ways each cancer cell can come up with to become resistant to drugs that are used in lung cancer standard therapies. My goal is to treat in the lab lung cancer cells with a number of drugs used in the clinic, and record the changes and responses that take place in surviving cells. By utilizing computational methods, these responses will then be used to build a reference map of possible responses a cancer cell may have to certain treatments. This way one could analyze a patient sample and test what type of a response that patient's cancer cells are having towards a certain drug at different time-points of therapy (before, during and after). Through collaborating with Stanford clinical oncologists, I will test this idea by analyzing patient samples obtained at different times during their therapy and see if by comparing with the constructed reference map, we can draw conclusions on how each patient is responding to therapy and see how this is correlated with smoking history. This could set the foundation towards developing prognostic and therapeutic tools that may help anticipate and counteract drug resistance at a personalized level, enabling precision medicine for current and former smokers suffering from lung cancer.
L’écriture du génocide dans les littéraures africaine et caribéenne d’expression française
Creators: name: Wattara, Mamadou F.
Publisher: name: No Publisher Supplied
Year: 2011

description: Evil is too often perceived in Manichean terms as the opposite of good. However literature has the potential to offer a more nuanced approach to the issue, especiallywhen treating accounts of genocide and mass atrocities. The focus will be on specific ways in which literature can bring to light the complexity of the reality of genocide, including victims’ reactions to the violence. Whereas it only takes but an instant for evil to manifest itself in a society, it often takes many generations to overcome its many consequences and to heal the invisible wounds. Of interest here are literarymanifestations of this process of healing. In genocide studies, evil is understood as embedded in the perpetrator’s very intent—to wipe out the victim’s entire family line, including women, children, and the elderly. This intent is what distinguishes genocide from conventional war and offers the justification of referring to it as “absolute evil.” Approaching a literary textthrough the theoretical tools provided by postcolonial, genocide, and trauma studies can articulate the complex and multi-faceted nature of historical events considered evil, including how both individuals and societies react to forms of collective violence. Using a comparative analysis of novels and films dealing with Rwanda and Haiti this study will consider how literature can bear witness to genocide, reveal the incommensurable human suffering that it causes, and reveal the psychological impact on individuals and the societies in which they live. Furthermore specialattention is given to exploring ways in which oral testimonies can challenge and subvert conventional historical representations.
“Where angels fear to tread”
Creators: name: Warner, Alex Ellis
Publisher: name: No Publisher Supplied
Year: 2011

description: This study is the first to document the history of the lesbian sadomasochist (SM) community and demonstrates its impact of the feminist Sex Wars in the United States between 1969 and 1993. Bringing together foundational literature and methods of inquiry from women’s studies, queer theory and the history of other excluded social groups, my dissertation highlights issues of power, resistance and collective identity formation.  Drawing on newspaper articles and other published sources, archival research and oral histories, I argue that one cannot understand the history of movements for gender, sexual and sexuality equality without also understanding this issue.  This project charts the evolution of feminist sexual theory from the 1960s through the 1990s, illuminates ruptures in feminist and gay/lesbian liberation theory and practice and reveals the history and the long-lasting implications of these debates.  I show how lesbian SM helped to shape the pornography debates, the development of both queer theory and the field of sexuality studies and was integral to major shifts in American politics and culture in the last two decades of the twentieth century.
Efficient Computation of Low-Rank Representations to Reduce Memory Requirements in LLM Training
Creators: name: Penke, Carolin
Publisher: name: Forschungzentrum Jülich
Year: 2024

description: LoRAINNe’24: workshop on LOw-Rank Approximations and their Interactions with Neural NEtworks, LoRAINNe’24, Nancy, France, 26 Nov 2024 - 27 Nov 2024
description: The OpenGPT-X project represents one of Europe’s pioneering publicly funded efforts in the domain of large language models (LLMs), covering the entire lifecycle from pre-training foundational models to fine-tuning and practical application development. To maximize the efficiency of training on High Performance Computing (HPC) resources, strategies aimed at reducing computational and memory demands are being explored. A promising avenue exploits the low-rank structure of gradients, as done in the LoRA or GaLore frameworks, the latter of which relies on the computation of dominant low-rank subspaces during training. The randomized range finder algorithm provides a more efficient alternative to computing a full singular value decomposition (SVD). We introduce a novel variant of the range finder, based on the blocked Householder QR decomposition, optimized for modern GPU accelerators.
Engineered Proteins to Reverse Chitin Buildup and Fibrotic Lung Disease
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Idiopathic pulmonary fibrosis is a progressive lung disease with a high mortality rate. Although there are many risk factors for pulmonary fibrosis (including tobacco use), the major driving causes are largely unknown. Our work suggests that exposure to environmental chitin, which is found in shellfish, parasitic worms, dust mites, and other insects – but not in mammals, is a major contributing factor to the development and aggravation of pulmonary fibrosis. Mouse experiments show that some of these symptoms can be relieved by treatment with enzymes that degrade chitin (chitinases). Our goal is to create “super-chitinases” that can be used as a treatment to reduce the accumulation of chitin and the inflammation that precedes the development of fibrosis. We will use new techniques in protein engineering and single molecule microscopy to create these new enzymes. We will test the “super-chitinases” in animals created with human genetic factors that pre-dispose individuals for spontaneous fibrotic lung disease. This research will apply protein engineering to test the hypothesis that an entirely new class of biologic can potentially relieve the progression of interstitial lung disease by breaking the cycle of inflammation and fibrosis caused by chitin, a major environmental irritant.
Negaprion Whitley 1940
Creators: name: Ebersole, Jun A.
name: Cicimurri, David J.
name: Stringer, Gary L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Elasmobranchii
Carcharhiniformes
Carcharhinidae
Negaprion

description: Genus Negaprion Whitley, 1940
Type species
Aprionodon acutidens subsp. queenslandicus Whitley, 1939, Recent.
description: Published as part of Ebersole, Jun A., Cicimurri, David J. & Stringer, Gary L., 2019, Taxonomy and biostratigraphy of the elasmobranchs and bony fishes (Chondrichthyes and Osteichthyes) of the lower-to-middle Eocene (Ypresian to Bartonian) Claiborne Group in Alabama, USA, including an analysis of otoliths, pp. 1-274 in European Journal of Taxonomy 585 on page 73, DOI: 10.5852/ejt.2019.585, http://zenodo.org/record/3660259
Preschoolers' and adults' belief reasoning and task demand
Creators: name: Wang, Lu
Publisher: name: No Publisher Supplied
Year: 2011

description: Thirty-years research seemed to reveal that there is a U-shape development in children’s  theory-of-mind abilities: infants have the competence to attribute false beliefs properly when  measured by looking time and anticipatory eye gaze, while children younger than four  systematically fail the standard false belief tasks measuring their voluntary responses. Why is  it, and why does the infants’ implicit belief reasoning seem to be free from the inhibition and  selection requirements? Are there really two systems, one explicit measured by verbal tasks  and one implicit shown in non-verbal context, involved in theory-of-mind reasoning? We  investigated preschoolers’ (experiment 1) and adults’ (experiment 2) belief attribution with  the anticipatory looking method, in both a low-demand and high-demand false-belief  reasoning tasks. Subjects’ nonverbal performances turned out to be better in the low-demand  condition: they showed strong bias to look at the locations congruent with the actor’s false  belief. However, neither adults’ nor children’s eye gaze in the high-demand condition showed  belief-congruent anticipations. Besides, adults’ predictions were better with verbal responses  than with nonverbal anticipatory eye gaze. Together, these results suggested that there are  dual systems involved in belief reasoning, and the two systems share similar property in  terms of their sensitivity to the task demands.
C-rel deficiency and its effect on proliferation and survival in immunodeficient lymphoblastic B cells
Creators: name: Valentin Acevedo, Anibal J.
Publisher: name: No Publisher Supplied
Year: 2011

description: The analysis of lymphocytes from immunodeficient patients has provided valuable insights into understanding the development and function of the immune system. In particular, studies of patients with Hyper IgM syndrome, a rare immunodeficiency resulting from defects in both CD40L in activated CD4+ T cells and components of the CD40 signaling pathway in B cells have been crucial for the elucidation of molecular pathways involved in the activation, proliferation and differentiation of B lymphocytes. Previously our lab generated EBV transformed lymphoblastic cells with inducible LMP1 from a female patient diagnosed with non-X-linked HIGM (Pt1-LCLtet cells, Pt1). Analysis of these cells revealed a CD40-specific activation defect associated with low c-Rel levels. To broaden our understanding of the Pt1 phenotype we analyzed c-Rel expression and found that low c-Rel levels were the outcome of depressed transcriptional activation of the c-rel promoter. In-vivo analysis revealed that low transcription was coincident with increased p65 activity at the c-rel promoter although this was insufficient to induce normal c-Rel expression. Further investigations of the Pt1-LCLtet cells uncovered a proliferation and survival defect characterized by reduced c-Myc transcription and increased levels of caspase-4. This defect was complemented after c-Rel overexpression, supporting a causative role for c-Rel deficiency in the observed phenotype of the Pt1-LCLtet cells. The LCLtet cells were further utilized as a model system for the independent analysis of LMP1 and CD40 signaling. These studies revealed several outcomes of LMP1 signaling in the biology and function of CD40. Specifically, LMP1 signaling induced a unique pattern of CD40 phosphorylation as well as the expression of several novel CD40 isoforms. Moreover, when CD40 and LMP1 were activated simultaneously a synergistic effect was observed towards p65 and p38 phosphorylation suggesting a functional interaction that might occur during early stages of EBV infection or malignant transformation where both LMP1 and CD40 are co-expressed in the infected cell. Collectively, our results demonstrate that a majority of the defects displayed in the Pt1-LCLtet cells are a result of reduced c-Rel expression. Importantly, these results ascribe c-Rel a novel function as a negative regulator of caspase-4 expression and a putative key player in the control of cell survival in EBV-immortalized B cells.
Mitigating pro-inflammatory non-agonist molecules from tobacco smoke
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: We investigate how cigarette smoke and e-cigarette associated chemical compounds can influence our immune system, which can influence disease and health outcomes on tobacco related cancer, respiratory diseases, and cardiovascular diseases. We have recently discovered a new form of molecular recognition which in principle allows the innate immune system to detect and respond to cigarette smoke associated compounds without having receptors specific to them. Having specific receptors that bind to specific ligand molecules has been one of the central paradigms of molecular biology, and usually described as a 'lock and key' mechanism. From our preliminary data on autoimmune diseases, we find something drastically different. New molecules that do not normally bind to these receptors can bind to the ligand molecules (the 'key' molecules that open the 'lock'), and form well-ordered crystals with them. This composite molecular complex not only binds the receptors ('opens the lock'), it causes a massive amplification of the immune system (by ~20000%). This effect occurs for psoriasis, lupus, and rheumatoid arthritis, which are precisely the autoimmune diseases to which smokers have increased susceptibility. In our preliminary analysis, we identify chemicals associated with cigarette smoke that are expected to have this ability to influence the immune system, which can broadly impact many smoking related health conditions. In our proposal, we propose novel ways to turn off this form of pathological immune amplification by custom-designed molecules that outcompete the cigarette smoke associate compounds and prevent them from forming these composite molecular complexes, which is a crucial step in the activation mechanism.
PODAGRA VA PODAGRIK NEFROPATIYANING BIOKIMYOVIY KO'RSATKICHLAR BILAN BOG'LIQLIGI
Creators: name: Raxmatov, A.M.
name: Zaripov, S.I.
Publisher: name: Zenodo
Year: 2024

description: Podagra — bu siydik kislotalarining organizmda to‘planishi va ularning birikmalarini hosil qilishi bilan xarakterlangan metabolik kasallikdir. Podagrik nefropatiya, o‘z navbatida, podagraga chalingan bemorlarda buyraklar funksiyasining buzilishi bilan kechadi. Ushbu tezisda podagra va uning asorati — podagrik nefropatiyaning rivojlanishiga aloqador biokimyoviy ko‘rsatkichlar, xususan, kreatinin va siydik kislotasi darajalarining ahamiyati o‘rganiladi.
An improved model for neurite guidance validatedto a novel micropatterned In vitro surrogate
Creators: name: Voyiadjis, Andrewv George
Publisher: name: No Publisher Supplied
Year: 2011

description: Recent research on repair mechanisms in injured spinal cords focuses on the regeneration of neurites across the injury site.  While integral to developing a therapy, regeneration does not ensure that neurites will reach their specific targets and develop functional recovery.  Regenerating neurites are less likely to reach their targets given their potential for misguided exploration.  To understand how the presence of numerous branches (e.g., spinal roots) along a spinal column may affect a neurite’s route, we (1) created a computational (in silico) model of neurite outgrowth which was applied to a pattern that resembles a spinal column with multiple roots, (2) engineered an in vitro model with identical patterns which was evaluated and compared to the in silico model, and (3) modified the patterns for both models to test how restricting neurite exploration into non-target roots affects neurite guidance to target roots.   The in silico model was constructed by analyzing dorsal root ganglion (DRG) neurite outgrowth on uniform laminin.  We simulated a pattern that resembles a 2-dimensional simplification of a spinal column with multiple roots.  From this model, we found that the likelihood of neurites reaching a root diminishes exponentially with root distance from the neurite’s initiation.   For the in vitro model, neurites from E7 chick DRG explant cultures were grown on a micropattern, identical to the in silico model.  In vitro and in silico neurite root preference were then compared, and were found to match significantly, thus validating the in silico model.   Finally, to understand the affect of non-target roots on guidance to target roots, we modified both models by removing non-target roots. We found that neurites were successfully guided to target roots when misguiding roots were removed, but only when targets are distant from the neurite’s origin in both models.   This research adds to the current understanding of neurite guidance in complex nervous systems and advances a predictive model for testing guidance strategies.  Both of the in vitro and in silico models will enhance clinical or in vivo research, which focus on improving functional recovery following nervous system injury.  These models will allow for a non-invasive, efficient, and cost effective way to test therapeutic guide strategies for treating nervous system injuries.
Structure-function analysis of the non-helicase domain of Sgs1, the Bloom Syndrome ortholog from Saccharomyces cerevisiae
Creators: name: Tuberty-Vaughan, Lynda
Publisher: name: No Publisher Supplied
Year: 2011

description: Bloom’s Syndrome (BS) is a rare human disease characterized by genome instability and cancer predispostion.  The gene mutated in BS, BLM, encodes a member of the RecQ family of DNA helicases. BLM is unique among this family because it is the only RecQ member conserved in unicellular eukaryotes.  Apart from the DNA helicase domain, BLM/SGS1 orthologs contain a poorly characterized N-terminal domain of about 650 amino acids (aa). In yeast, this domain (Sgs1 1-652) is known to be physiologically important although it’s only known roles are to bind Top3 and Rmi1 through its N-terminal 100 aa, and in vitro single-strand DNA (ssDNA) binding, ssDNA annealing and strand exchange (SE) activities, through its SE domain (Sgs1 103-323)  My research consisted of structure/function analyses of Sgs1 in its poorly characterized N-terminus of  aa 323-652 and I found a domain that is important to Sgs1’s function. I interrogated this region by doing systematic deletions and tested these sgs1 mutants for complementation of synthetic lethality. The allele with the smallest deletion that did not complement sgs1slx4 synthetic lethality was found to be sgs1-∆386-621, and the allele with the smallest deletion that did not complement sgs1slx5, was found to be sgs1-∆500-621.  I found that sgs1-∆386-621 is physiologically important also through the Top3 slow growth assay. Furthermore I believe that the difference in results between sgs1slx4 and sgs1slx5 will prove significant and warrants further investigation.   I also used a BLM/GCN4 chimera where the SE domain was replaced with the coiled coil GCN4, and again tested alleles with systematic deletions within aa 323-652 in synthetic lethality assay. I found the smallest essential domain to be sgs1/gcn4-∆500-621 in the sgs1slx4 background, and interestingly the same deletion in sgs1-∆500-621 did grow weakly and complemented synthetic lethality.  Therefore I postulate there is some interaction between the SE domain and aa 500-621 that could be physiologically important and again warrants further investigation.
The ecology, effect of dams, and restoration of the black cottonwood (Populus trichocarpa T. & G.) forest community in the Intermountain West
Creators: name: Tiedemann, Robert Bruce
Publisher: name: No Publisher Supplied
Year: 2011

description: The black cottonwood riparian forest is an important component of the otherwise xeric landscapes of the Intermountain West of North America.  Regulation of rivers by dams has attenuated peak flood flow events, quickened the rate of decline in river stage after the peak event, and hindered the delivery of maintenance flows throughout the remainder of the growing season.  As a result, sexual reproduction of trees has been diminished causing the population to be largely a result of vegetative growth from roots and runners.    Field studies, examination of historic hydrology data, and large-scale in-situ experiments along the Boise River in Southwest Idaho provide the evidence to conclude this population too has been adversely affected by a change in the hydrology of the river, but remains capable of reproducing from seed if the surface of the floodplain is artificially disturbed to prepare a proper seedbed.  Further, it shows the intentional manipulation of the source of soils can produce differing communities of understory shrubs, grasses, and forbs with some more desirable than others.    With this information restoration ecologists can now better prescribe the means and methods to grow a native array of plants that complement adjacent landscapes, resist invasion by exotic species, and offer the greatest probability of survival and growth of individual plants.
Effects of cigarette smoke on inflammasome activation in oral cells
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cigarette smoking harms nearly every organ of the body, causes many diseases, and reduces the health of smokers in general, increasing the risk of dying, according to the Center of Disease Control and Prevention (Services U.S. CDC, 2017). Smoking is a very common habit among the US population and has been recognized as one of the major risk-factors for an ever-increasing number of diseases and conditions in men and woman, such as heart and respiratory disease, several kinds of cancer and oral health. Periodontal disease is an oral chronic inflammatory disease that affects half of the US population and it can cause irreversible tooth loss. There are studies showing a strong association between smoking and periodontal disease in humans, and also between some exacerbated host defenses and induction of disease. However, how smoking leads to disease still remains to be completely understood. Here we propose to investigate the mechanisms involved in host defenses that are associated with a group of proteins that can sense stress or cellular damage and can initiate an inflammatory response. These proteins form a complex called an “inflammasome”. We also will examine how cigarette smoking extracts regulate our immune defenses against oral bacteria associated with periodontal disease. Our findings will be the first to determine whether the inflammasome plays a role in smoking-related risk for periodontal disease. As pharmaceutical inhibitors and activators of inflammasome components are already being developed for other diseases, our findings may raise the possibility of targeting the inflammasome therapeutically for treatment of smoking-induced disease.
Community College Smokefree Policies: Disparities, Contexts and Strategies
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: At the 2013 Health Equity Summit of the California Tobacco Control Program, establishing tobacco-free campuses at community colleges (CCs) was recognized as a top priority to reduce tobacco-related health disparities. California (CA) State Assembly Bill 1594 would have instantly achieved the state’s Health Equity priority to ban smoking and tobacco use in CCs, but the governor vetoed this bill in 2016. As of 2018, only 52 of the 114 CC campuses in CA have 100% smoke-free or tobacco-free policies, in stark contrast to CA’s 4-year public colleges which are all 100% tobacco-free. Recognizing that CCs are often more under-resourced and under-funded than 4-year colleges and that the CC student population is racially/ethnically diverse, disproportionately lower-income, and at greater risk for tobacco-related harms than other college students, it is vital to elucidate factors influencing CC adoption of smoke-free policies and to identify best strategies to facilitate smoke-free policy adoption at remaining CCs. Doing so is an important step towards achieving the state’s Health Equity goal of reducing tobacco-related disparities. Importantly, as most CCs are commuter campuses with little-to-no campus housing, this study looks beyond the campus to the community context in which CCs are situated, and the tobacco environment it presents. This TRDRP New Investigator Study will examine both campus and community influences on smoke-free policy adoption in CCs. This study will involve various research methods, including analyses of tobacco control policy databases, school administrative records, survey data, Census and other types of data, along with case studies of 10 CCs that include key informant interviews and site visits. Study findings will point to influential factors that may be intervened upon, and successful strategies that have been used, to facilitate the adoption of smoke-free policy at CA CCs. Findings of this nature can help with efforts to overcome institutional and other barriers to smoke-free policy adoption at the 62 CCs that have not yet committed to a 100% smoke-free campus, and can point to more effective environmental strategies to reduce tobacco-related disparities.
Socratic dialectic and the resolution of fallacy in Plato's Euthydemus
Creators: name: Swanson, Carrie Elizabeth
Publisher: name: No Publisher Supplied
Year: 2011

description: My dissertation is devoted to an examination of the resolution of fallacy in Plato's Euthydemus. It is a familiar claim that the Euthydemus champions Socratic argumentation over sophistical or eristic reasoning. No consensus however exists regarding either the nature or philosophical significance of Socrates’ treatment of the fallacies he confronts. I argue that a careful reading of the dialogue reveals that the Socratic response to fallacious reasoning is conducted at two different levels of philosophical sophistication. Socrates relies upon the resources of Socratic dialectic in responding to sophisms due to ignorance of refutation. Insofar as Socratic dialectic is grounded in a grasp of the nature of genuine refutation, the objections it raises to false refutation are fully explanatory. On the other hand, Socrates employs various self-refutation arguments against theses which depend on false assumptions regarding the nature of predication---for example, the thesis that false speaking is impossible. It is however characteristic of Socratic dialectic that this method of examination cannot explain why the sophists’ theses are false. The Socratic response to fallacy in these cases is non-explanatory in this sense. On the other hand, these limitations on Socratic expertise are overcome in other passages in the dialogue which are replete with clues to the reader that point to a genuine explanation and resolution of the sophists’ arguments for their various theses. In particular, the reader is invited at every turn to modify, clarify, or reject various assumptions made by the brothers regarding the nature of predication. Here Plato implicitly relies on the results of what I call higher dialectic. This theory, which receives explicit formulation in the Sophist, is conceptually rich enough to expose and dispose of the various false assumptions upon which the sophists’ theses rest. I conclude that the Euthydemus is concerned to identify Socratic dialectic as only a part of philosophy, and to locate and strictly delimit its epistemological status as lying above eristic and the rhetorical arts, but below that of dialectic as that is conceived in the Republic and even later dialogues---thus anticipating the Sophist’s conception of Socrates as the practitioner of a ‘noble sophistry’, (gennaia sophistike,  231b3-8) and the elenchus as a propaedeutic to philosophy, which purges the soul of false beliefs.
Inventaire du fonds Bastaire de littérature populaire et infantine [version 1]. Romans d'amour (grand et petit format) (S.E.T.) (et divers)
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024

description: Numérisation ICB CollEx-Persée AAP20212022
description: Les titres sont ceux donnés par Jean Bastaire. Les dates indiquées ont été établies depuis un courrier de Jean à Michel Bastaire qui lui demandait de dresser l'inventaire. Et la date de fin correspond à la donation et à la publication de Lectures englouties. Listes manuscrites de la collection établie par Jean Bastaire et Michel Bastaire ; Jean sous forme de livrets thématiques et feuilles volantes au format A5. Michel a consigné les titres dans un carnet bloc type Rhodia format A6.
description: Source: Fonds Bastaire Université Clermont Auvergne (Bas-G08_D041)
description: Relation: http://www.calames.abes.fr/pub/ms/_631139801_Bas-G08_D041
description: created: 1993/2008
"No more canaries in the coal mine!"
Creators: name: Sutton, Rachel L.
Publisher: name: No Publisher Supplied
Year: 2011

description: Despite federal, state and municipal policies implemented since the early 20th century to reduce the prevalence of lead poisoning there are still many people living in the United States who are at-risk of being exposed to lead. In an effort to reduce lead poisoning risk further in the United States this thesis examines how various lead poisoning experts in Mercer County, New Jersey define and perceive the “lead-poisoning risk-subject.” By means of analyzing how lead poisoning experts perceive the risk of lead poisoning this research works towards understanding and deconstructing the underlying assumptions pervading within experts’ discourses surrounding who lead effects, where it is most prevalent, and what the most effective solutions are in reducing the sources of lead exposure. This research adds to the current lead poisoning literature by means of pointing out the limitations of using risk factors to define lead poisoning risk and offering a new framework through which lead poisoning risk may be more productively measured. Furthermore, this research argues that in order for there to be a permanent reduction of the sources of lead exposure the “lead problem” needs to be re-politicized and constructed as a problem which effects a variety of people living across geographical, racial and class boundaries. By means of making lead poisoning into a problem the public can “see” we may be able to truly make lead poisoning a thing of the past.
Elucidating the genetic basis of nicotine dependence by using electronic health records
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Smoking is the leading cause of preventable death worldwide, causing 6 million annual premature deaths. Genetic factors influence an individual’s susceptibility to nicotine dependence by acting at multiple stages, including the decision to begin smoking, sensitivity to the subjective effects of the drug, development of tolerance, severity of drug withdrawal, inclination to quit, and ability to quit. This project examines the individual differences, or genetic factors, that cause some people to be at risk of nicotine dependence more than others. We will identify individuals with nicotine dependence from one of the largest repositories for biological samples in the US containing DNA and rich data on health status and other individual characteristics from electronic health records. We will use these extensive data to perform a large scale genetic study to identify specific genes that confer risk for nicotine dependence. We will also quantify the genetic risk for nicotine dependence, and evaluate its role in other forms of substance abuse, and other psychiatric and medical conditions, such as major depressive disorder and obesity. Our study has thus the potential to further our understanding about why some individuals are at greater risk to begin smoking, and have more trouble quitting. Ultimately, this work will allow prevention and cessation treatments to be tailored to individual genetic differences.
The Effect of Combined Tobacco and Marijuana Use on Pulmonary Function: A Pilot Study
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Marijuana is legal in some form in 30 states and Washington DC. Use of all forms of marijuana is increasing among US adults. Smoking remains the most common form of marijuana used. The increasing rates of smoking marijuana among US adults raises concerns about the combined effect of smoking tobacco and marijuana on lung health.

 Little is known about the effects of marijuana on lung health; however, marijuana smoke contains particulate matter known to be detrimental to lungs. Marijuana smoke like tobacco smoke also causes inflammation in the lung. As such, it is possible that combined tobacco and marijuana use accelerates lung damage. Data is insufficient on this topic as previously studied populations have not been representative of regular marijuana users.

 We are proposing a pilot study among Veterans in Northern California. The purpose of this pilot study is to develop the tools and test the methods that can be used to develop a larger cohort study that will examine the association of combined marijuana and tobacco use on health.

 In this pilot study, we propose to 1) develop an algorithm that will identify Veterans who have used both tobacco and marijuana using VA data; 2) develop a reliable questionnaire to measure lifetime marijuana use; and 3) test our study participant recruitment methods. We will identify Veterans using an algorithm we will develop for this study, recruit eligible participants using a recruitment letter, complete a telephone interview, and invite eligible participants for the pulmonary function testing. This pilot will inform a larger study on the effects of combined lifetime use of tobacco and marijuana on lung health and will be useful to researchers, public health officials, physicians and the general public.
MALEG - Machine Learning for Enhancing Geothermal Energy Production
Creators: name: Trumpp, Michael
name: Yström, Lars Helge
Publisher: name: Karlsruher Institut für Technologie (KIT)
Year: 2024

description: To improve the efficiency of geothermal energy production the reinjection temperature has to be reduced. Yet in most cases, the geothermal fluid composition is counteracting this temperature reduction. Whilst pressure relief or cooling, highly mineralised geothermal fluids tend to rise uncontrolled mineral precipitation (scaling). This is a strict limiting factor for the efficient and continuous operation of geothermal power plants. The complex and site-specific hydrochemistry of the fluids complicates the prediction and quantification of scalings using deterministic geochemical models. In the MALEG project, geochemical models are complemented by artificial intelligence, which is trained with hydrochemical data provided by on-site experiments. 
 
For this purpose, a demonstrator is built resembling a hardware twin of the geothermal power plant, which is capable of representing the thermodynamic processes in the system. The demonstrator will be connected to the power plant via a bypass to conduct hydrochemical precipitation experiments. Continuous monitoring of fluid and solid samples accompanies the experiments to evaluate potential mineral precipitation. These precipitation processes are dependent on the chemical milieu of the fluid. Changing system parameters such as pressure, temperature, pH, or ion concentration enable the formation of scaling. The application of the demonstrator and the corresponding hydrochemical experiments are planned for three geothermal systems involving different reservoir conditions. The collected and analysed data will set up a diverse hydrochemical database, which will be used to develop the AI-based prediction tool “MALEG”. In addition, a digital twin consisting of deterministic geochemical models will validate the predictions of “MALEG”. Thus, the impact of changes in the fluid chemistry can be predicted more accurately. Evaluating scaling formation will allow optimisation of geothermal power plant operating parameters for improving efficiency, the introduction of cascade utilisation, integration of mineral extraction processes, or cost reduction of routine hydrochemical monitoring.
Tobacco cessation and prevention for underserved Arab Americans: A pilot study
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: For our High Impact Pilot study we propose to develop a new program to help Arab Americans quit smoking cigarettes and narghile (also called hookah, or waterpipe). Arab Americans are often excluded from community health studies, despite Arab American presence in the US for over a century. Some studies show that as many as 60% of adult Arab Americans smoke, compared to 16% of all US adults. In many Arab countries, cigarette smoking is normal for men, and narghile smoking may be normal for men and women. Cigarette smoking increases risk for heart and lung disease and other illnesses for people who smoke, and for their household members if they smoke at home. Narghiles have many of the same risks as cigarettes, but people may not know this. Of the 3.5 million Arab Americans, the largest percent live in California. In the East Bay Area, where there are many Arab Americans and Arab immigrants from lower-income countries (for example Yemen) there are no health clinics devoted to Arab Americans. There are low-cost and free resources to help smokers quit and prevent secondhand smoke harms. Stress and worries about discrimination, including rising Islamophobia, may make it harder for Arab Americans to quit smoking and to seek help for quitting. However, in the Bay Area there are strong social networks and dedicated Arab American community organizations and leaders. Talking with a trained medical helper can help people change their habits. There are places where Arab Americans can gather together to talk about problems and how to improve their lives. Community leaders can help us organize a smoking awareness, cessation, and prevention program in these places. With collaboration and mutual respect, we can build a good partnership to do this work. We propose to (1) Develop a Community Advisory Board of Arab American leaders and healthcare providers; (2) Collect information from the community about cigarette and narghile use, and about how they might be helped to cut back and quit smoking, as well as collect information about what resources are available and how to use them; and (3) Design and test a pilot project to see if we can help Arab Americans quit and reduce home smoking. If this project works well, we can develop a next study that will use the program to help reduce smoking for more Arab Americans in the Bay Area and other California cities.
Conditional futures
Creators: name: Sudhakar, Anantha
Publisher: name: No Publisher Supplied
Year: 2011

description: Conditional Futures: South Asian American Cultural Production and Community Formation, 1991-2001 traces the development of a politically engaged diasporic consciousness, expressed in contemporary South Asian American literature and other media during the period between the Persian Gulf War and 9/11. This diasporic consciousness sought to challenge the assimilationist, “model minority” selfrepresentation of a previous generation of South Asian American professionals. Responding instead to a set of transnational shifts that shaped the 1990s—including India’s economic liberalization in 1991 and the post-Cold War rise of U.S. military and commercial global dominance—contemporary South Asian American artists and cultural critics, such as Vivek Bald, Meena Alexander, Shani Mootoo, Amitava Kumar and Vijay Prashad, reframed diasporic community as cohering around shared politics, rather than shared origins. Drawing upon a grassroots archive of community organization newsletters, arts periodicals and personal interviews, my analysis reveals the multiple spatial scales of transnationalism that contextualize these artists’ and scholars’ projects: global changes in labor and migration as a result of economic liberalization, on one hand; and a hemispheric diasporic arts activism aligned with feminist, queer and antiracist organizing in New York City and Toronto, on the other. I locate aesthetic innovation as an important response to fiscal and social reforms during the premillennial decade, as it provided a creative plane through which artists imagined “conditional futures”—modes of collectivity that did not yet exist, but could possibly evolve.
A prospective examination of Beck’s cognitive theory of depression in university students in mainland China
Creators: name: Stolow, Darren
Publisher: name: No Publisher Supplied
Year: 2011

description: The current multi-wave longitudinal study examined the applicability of Beck’s (1967, 1983) cognitive theory of depression to university students in mainland China. During an initial assessment, participants completed measures assessing dysfunctional attitudes and depressive/anxious symptoms. Participants subsequently completed measures assessing negative events and depressive/anxious symptoms once a month for six months. Results provided support for the applicability of Beck’s cognitive theory to university students in mainland China. More specifically, higher levels of dysfunctional attitudes were associated with greater increases in depressive symptoms following the occurrence of negative events. At the same time, contrary to findings obtained in Western samples, higher levels of dysfunctional attitudes were also associated with greater increases in anxious symptoms following the occurrence of negative events. These findings may suggest that dysfunctional attitudes exhibit non-specificity as a predictor of depressive symptoms in mainland China.
Number words and the object wide scope puzzle
Creators: name: Suarez, Marta T.
Publisher: name: No Publisher Supplied
Year: 2011

description: Sentences such as Three girls are holding two balloons, whose subjects and objects are quantified by bare numeral expressions, logically allow multiple readings. The semantics literature has reported that the so-called object wide scope distributive reading, (interpreted as having 6 girls and 2 balloons, each balloon held by 3 girls), is usually not accessible. Recent experimental studies showed the reading was accessible, albeit massively dispreferred (Musolino, 2009; Syrett & Musolino, in prep.) We report the findings of two experiments that tested competing theoretical accounts of why this reading should be disallowed. On one account, the syntactic configurations and operations required to generate the reading are not permitted by the grammar (Beghelli & Stowell, 1997). On the other, the reading is taken to be allowed by the grammar but rendered inaccessible by excessive processing costs (Reinhart, 2006). Crucially, this account involves the semantic nature of the subject; when it allows both a distributive and a collective interpretation, the computation of all possible readings exceeds working memory capacity. It straightforwardly predicts that if a collective reading can be forced by adding a modifier, e.g., Three girls together are holding two balloons, the object wide scope reading should become acceptable. This was reported to be the case for a small number of informally consulted subjects.        Experiment 1 piloted 5 lexical items within subjects, all with singular indefinite subjects (N = 42). Results revealed that participants accepted the object wide scope reading, as predicted. However, clear item effects were found, contra the literature. Experiment 2 varied 3 types of subject noun phrase between groups: singular indefinites, bare numeral quantifiers and bare numeral quantifiers plus a collectivizing modifier. It also tested 4 lexical items from Experiment 1 within subjects (N = 132). Results revealed: 1- the object wide scope reading was acceptable to most participants, with or without modification, contra both theoretical claims and previous experimental findings; and 2- clear differences among lexical items, replicating Experiment 1. These findings suggest that participants did not treat all internal arguments equally. Rather, they were sensitive to the argument structure of the verbs, distinguishing true transitives from unaccusatives.
MPEC 2024-X244 : 2024 XY10
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 XY10

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.