cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sacituzumab govitecan in metastatic triple-negative breast cancer
Creators: name: Dalenc, F.
name: Carey, L.A.
name: O'Shaughnessy, J.
name: Itri, L.M.
name: Brufsky, A.
name: Gianni, L.
name: Punie, K.
name: Ferrario, C.
name: Tolaney, S.M.
name: Olivo, M.S.
name: Zelnak, A.B.
name: Rugo, H.S.
name: Schmid, P.
name: Diéras, V.
name: Lynce, F.
name: Goldenberg, D.M.
name: Hong, Q.
name: Cortés, J.
name: Oliveira, M.
name: Sardesai, S.D.
name: Bardia, A.
name: Diab, S.
name: ASCENT Clinical Trial Investigators
name: Loirat, D.
name: Piccart, M.J.
name: Kalinsky, K.
name: Weaver, R.
name: Loibl, S.
name: Traina, T.
name: Hurvitz, S.A.
name: Aftimos, P.
Publisher: name: Massachussetts Medical Society
Year: 2021

description: BACKGROUND: Patients with metastatic triple-negative breast cancer have a poor prognosis. Sacituzumab govitecan is an antibody-drug conjugate composed of an antibody targeting the human trophoblast cell-surface antigen 2 (Trop-2), which is expressed in the majority of breast cancers, coupled to SN-38 (topoisomerase I inhibitor) through a proprietary hydrolyzable linker. METHODS In this randomized, phase 3 trial, we evaluated sacituzumab govitecan as compared with single-agent chemotherapy of the physician's choice (eribulin, vinorelbine, capecitabine, or gemcitabine) in patients with relapsed or refractory metastatic triple-negative breast cancer. The primary end point was progression-free survival (as determined by blinded independent central review) among patients without brain metastases. RESULTS A total of 468 patients without brain metastases were randomly assigned to receive sacituzumab govitecan (235 patients) or chemotherapy (233 patients). The median age was 54 years; all the patients had previous use of taxanes. The median progression-free survival was 5.6 months (95% confidence interval [CI], 4.3 to 6.3; 166 events) with sacituzumab govitecan and 1.7 months (95% CI, 1.5 to 2.6; 150 events) with chemotherapy (hazard ratio for disease progression or death, 0.41; 95% CI, 0.32 to 0.52; P<0.001). The median overall survival was 12.1 months (95% CI, 10.7 to 14.0) with sacituzumab govitecan and 6.7 months (95% CI, 5.8 to 7.7) with chemotherapy (hazard ratio for death, 0.48; 95% CI, 0.38 to 0.59; P<0.001). The percentage of patients with an objective response was 35% with sacituzumab govitecan and 5% with chemotherapy. The incidences of key treatment-related adverse events of grade 3 or higher were neutropenia (51% with sacituzumab govitecan and 33% with chemotherapy), leukopenia (10% and 5%), diarrhea (10% and <1%), anemia (8% and 5%), and febrile neutropenia (6% and 2%). There were three deaths owing to adverse events in each group; no deaths were considered to be related to sacituzumab govitecan treatment. CONCLUSIONS Progression-free and overall survival were significantly longer with sacituzumab govitecan than with single-agent chemotherapy among patients with metastatic triple-negative breast cancer. Myelosuppression and diarrhea were more frequent with sacituzumab govitecan.
Low-Cost Traffic Sensing System Based on LoRaWAN for Urban Areas
Creators: name: Pasandi, Hannaneh Barahouei
name: Haghighat, Asma
name: Moradbeikie, Azin
name: Keshavarz, Ahmad
name: Rostami, Habib
name: Paiva, Sara
name: Lopes, Sergio Ivan
Publisher: name: arXiv
Year: 2022
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: The advent of Low Power Wide Area Networks (LPWAN) has enabled the feasibility of wireless sensor networks for environmental traffic sensing across urban areas. In this study, we explore the usage of LoRaWAN end nodes as traffic sensing sensors to offer a practical traffic management solution. The monitored Received Signal Strength Indicator (RSSI) factor is reported and used in the gateways to assess the traffic of the environment. Our technique utilizes LoRaWAN as a long-range communication technology to provide a largescale system. In this work, we present a method of using LoRaWAN devices to estimate traffic flows. LoRaWAN end devices then transmit their packets to different gateways. Their RSSI will be affected by the number of cars present on the roadway. We used SVM and clustering methods to classify the approximate number of cars present. This paper details our experiences with the design and real implementation of this system across an area that stretches for miles in urban scenarios. We continuously measured and reported RSSI at different gateways for weeks. Results have shown that if a LoRaWAN end node is placed in an optimal position, up to 96% of correct environment traffic level detection can be obtained. Additionally, we share the l
description: 7 pages, accepted to Emerging Topics in Wireless (EmergingWireless) in CoNEXT 2022
FOXA1 and adaptive response determinants to HER2 targeted therapy in TBCRC 036
Creators: name: Thompson, A.M.
name: Rashid, N.U.
name: Chen, X.
name: Bevill, S.M.
name: Gallagher, K.K.
name: Jefferys, S.
name: Goulet, D.R.
name: Singh, D.
name: Angus, S.P.
name: Johnson, G.L.
name: Fan, C.
name: Sciaky, N.
name: East, M.P.
name: Earp, H.S.
name: He, X.
name: Zawistowski, J.S.
name: Murthy, R.
name: Spears, P.A.
name: Tanioka, M.
name: Mehta, G.
name: Perou, C.M.
name: Krop, I.E.
name: Parker, J.S.
name: Carey, L.A.
name: Stuhlmiller, T.J.
name: Chollet-Hinton, L.
name: Soloway, M.G.
name: Olivares-Quintero, J.F.
name: Gatza, M.L.
name: Forero-Torres, A.
Publisher: name: Nature Research
Year: 2021

description: Inhibition of the HER2/ERBB2 receptor is a keystone to treating HER2-positive malignancies, particularly breast cancer, but a significant fraction of HER2-positive (HER2+) breast cancers recur or fail to respond. Anti-HER2 monoclonal antibodies, like trastuzumab or pertuzumab, and ATP active site inhibitors like lapatinib, commonly lack durability because of adaptive changes in the tumor leading to resistance. HER2+ cell line responses to inhibition with lapatinib were analyzed by RNAseq and ChIPseq to characterize transcriptional and epigenetic changes. Motif analysis of lapatinib-responsive genomic regions implicated the pioneer transcription factor FOXA1 as a mediator of adaptive responses. Lapatinib in combination with FOXA1 depletion led to dysregulation of enhancers, impaired adaptive upregulation of HER3, and decreased proliferation. HER2-directed therapy using clinically relevant drugs (trastuzumab with or without lapatinib or pertuzumab) in a 7-day clinical trial designed to examine early pharmacodynamic response to antibody-based anti-HER2 therapy showed reduced FOXA1 expression was coincident with decreased HER2 and HER3 levels, decreased proliferation gene signatures, and increased immune gene signatures. This highlights the importance of the immune response to anti-HER2 antibodies and suggests that inhibiting FOXA1-mediated adaptive responses in combination with HER2 targeting is a potential therapeutic strategy.
The Collaborative Business Intelligence Ontology (CBIOnt)
Creators: name: Fahad, Muhammad
name: Darmont, Jérôme
name: Favre, Cécile
Publisher: name: arXiv
Year: 2022
Subjects: subject: Databases (cs.DB)
subject: FOS: Computer and information sciences

description: In the current era, many disciplines are seen devoted towards ontology development for their domains with the intention of creating, disseminating and managing resource descriptions of their domain knowledge into machine understandable and processable manner. Ontology construction is a difficult group activity that involves many people with the different expertise. Generally, domain experts are not familiar with the ontology implementation environments and implementation experts do not have all the domain knowledge. We have designed Collaborative Business Intelligence Ontology (CBIOnt) for BI4People project. In this paper, we present CBIOnt that is OWL 2 DL ontology for the description of collaborative session between different collaborators working together on the business intelligent platform. As the collaborative session between various collaborators belongs to some collaborative form, phase and research aspect, therefore CBIOnt captures this knowledge along with the collaborative session content (comments, questions, answers, etc.) so that one can inference various types of information stored on ontologies when required. In addition, it stores the location and temporal-spatial information about the collaboration held between collaborators. We believe CBIOnt serves as a formal framework for dealing with the collaborative session taken place among collaborators on the semantic Web.
Exercise interventions, physical function, and mobility after hip fracture: a systematic review and meta-analysis
Creators: name: Zhang, Xiaorui
name: Butts, William J.
name: You, Tongjian
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: To investigate the effects of different exercise components on physical function and mobility in adults after hip fracture. Pubmed, Embase, Cochrane Library, Web of Science, CINAHL, and PsycINFO were searched up to March 2021. Randomized controlled trials investigating the effects of exercise interventions on physical function and mobility in adults after hip fracture were included. Fifteen studies (12 trials) were included (n = 1198, age = 80 ± 8 years). Exercise interventions had a moderate effect on overall physical function after hip fracture compared to non-exercise (SMD = 0.46, 95% CI = 0.27–0.65). Among different exercise components, progressive resistance exercise showed the largest effect (SMD = 0.48, 95% CI = 0.27–0.69), while aerobic exercise alone had no effect (SMD 0.41, 95% −0.44 to1.26) on physical function. Exercise had a small effect on mobility (SMD = 0.28, 95% CI = 0.12–0.43). Specifically, functional exercise showed a moderate effect (SMD = 0.41, 95% CI = 0.16–0.65) on mobility. Available evidence supports that exercise interventions improve physical function and mobility in older adults after hip fracture; specifically, resistance exercise with progressive load of 60–80% 1RM, and functional exercise may be critical intervention components respectively. Future high-quality research is needed to establish best practices. IMPLICATIONS FOR REHABILITATIONProgressive resistance exercise with 60–80% 1RM resulted in the largest improvement in physical function after hip fracture.Functional exercise appears to be a critical component for improving mobility after hip fracture. Functional exercise plus resistance and balance exercises was the most effective intervention for enhancing mobility.Exercise should be supervised by a trainer or a physiotherapist, and self-reported exercise may not result in the same benefits. Progressive resistance exercise with 60–80% 1RM resulted in the largest improvement in physical function after hip fracture. Functional exercise appears to be a critical component for improving mobility after hip fracture. Functional exercise plus resistance and balance exercises was the most effective intervention for enhancing mobility. Exercise should be supervised by a trainer or a physiotherapist, and self-reported exercise may not result in the same benefits.
ЭКОНОМИЧЕСКАЯ БЕЗОПАСНОСТЬ ПРЕДПРИЯТИЙ МАЛОГО И СРЕДНЕГО БИЗНЕСА
Creators: name: Н. В. Тарасова
name: В. М. Попова
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: экономическая безопасность
малое предприятие
угрозы экономической безопасности
финансовая безопасность
субъект малого предпринимательства
экономическое развитие

description: В данной статье анализируется роль малого бизнеса в экономической системе российской Федерации. Определяется актуальность такой категории как экономическая безопасность в системе субъектов малого и среднего предпринимательства. Раскрываются ключевые факторы, влияющие на уровень экономической безопасности малых и средних предприятий. Авторами сделан вывод о том, уровень финансовой безопасности является основным элементом в системе экономической безопасности малого бизнеса. От качества управления рисками зависит эффективность развития сектора малого предпринимательства в экономической системе России.
РЕГИОНАЛИЗАЦИЯ КАК ФАКТОР УСТОЙЧИВОГО СОЦИАЛЬНО-ЭКОНОМИЧЕСКОГО РАЗВИТИЯ РЕСПУБЛИКИ БЕЛАРУСЬ
Creators: name: Ф. И. Храмцова
name: Е. М. Андрейковец
name: А. А. Рыжанкова
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: зеркальная регионализация; институционализация; регион
национальная экономика; управление; институциональный механизм; устойчивое развитие; международное сотрудничество

description: Раскрыта методология регионализации как основа государственного управления в условиях международного и трансграничного сотрудничества. Введена в научный оборот категория зеркальной регионализации на основе интерпретации факторов, тенденций, трендов социально-экономических процессов и отношений. Уточнена сущность понятий «институциональная идентичность», «институциональный изоморфизм» как элементов системы управления. Раскрыт институциональный потенциал устойчивого развития. Предложены рекомендации по совершенствованию институционального механизма устойчивого социально-экономического развития.
Scaling relations and multicritical phenomena from Functional Renormalization
Creators: name: Boettcher, Igor
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We investigate multicritical phenomena in O(N)+O(M)-models by means of nonperturbative renormalization group equations. This constitutes an elementary building block for the study of competing orders in a variety of physical systems. To identify possible multicritical points in phase diagrams with two ordered phases, we compute the stability of isotropic and decoupled fixed point solutions from scaling potentials of single-field models. We verify the validity of Aharony's scaling relation within the scale-dependent derivative expansion of the effective average action. We discuss implications for the analysis of multicritical phenomena with truncated flow equations. These findings are an important step towards studies of competing orders and multicritical quantum phase transitions within the framework of Functional Renormalization.
description: 10 pages, published version
Quanto custa formar um médico? Descrição de Sistema informatizado de coleta de dados capaz de receber e acumular os dados e informações necessários ao cálculo do custo-padrão dos cursos de medicina
Creators: name: Silva Jr., Dercio S.
name: Maia, Leila S.
name: Dal Poz, Mario R.
Publisher: name: Zenodo
Year: 2022

description: Este texto dá seguimento ao conteúdo iniciado na nossa NT anterior, na qual foi descrita a metodologia de custo-padrão a ser aplicada a um curso de graduação em medicina. Apesar de os cursos de graduação em medicina apresentarem custos elevados e serem objeto de importantes políticas públicas, o levantamento bibliográfico aponta que muito pouco foi escrito sobre os modos de apurar seus custos. Aquele primeiro projeto descreveu a metodologia. Este descreve o sistema de coleta e registro de dados, incluindo a sequência de coleta, o conteúdo dos formulários e as tabelas do banco de dados. This text continues the content started in our previous NT, in which the standard cost methodology to be applied to an undergraduate medical course was described. Despite the fact that undergraduate courses in medicine have high costs and are the object of important public policies, the bibliographic survey indicates that very little has been written about ways to determine their costs. The first project described the methodology. This one describes the data collection and recording system, including the collection sequence, the content of the forms and the database tables.
Biomimetic Rose Petal Structures Obtained Using UV-Nanoimprint Lithography
Creators: name: Oopath, Sruthi Venugopal
name: Baji, Avinash
name: Abtahi, Mojtaba
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 34
subject: Chemical sciences
subject: FOS: Chemical sciences
classificationCode: 40
subject: Engineering

description: This study aims to produce a hydrophobic polymer film by mimicking the hierarchical micro/nanostructures found on the surface of rose petals. A simple and two-step UV-based nanoimprint lithography was used to copy rose petal structures on the surface of a polyurethane acrylate (PUA) film. In the first step, the rose petal was used as a template, and its negative replica was fabricated on a commercial UV-curable polymer film. Following this, the negative replica was used as a stamp to produce rose petal mimetic structures on UV curable PUA film. The presence of these structures on PUA influenced the wettability behavior of PUA. Introducing the rose petal mimetic structures led the inherently hydrophilic material to display highly hydrophobic behavior. The neat PUA film showed a contact angle of 65°, while the PUA film with rose petal mimetic structures showed a contact angle of 138°. Similar to natural materials, PUA with rose petal mimetic structures also displayed the water pinning effect. The water droplet was shown to have adhered to the surface of PUA even when the surface was turned upside down.
5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5)
Creators: name: Senkus, E.
name: Neciosup, S.
name: Wiseman, T.
name: Costa, A.
name: Norton, L.
name: Winer, E.P.
name: Elzayat, M.
name: Sledge, G.W.
name: Mertz, S.A.
name: Bergh, J.
name: Eniu, A.
name: Thomssen, C.
name: Kaufman, B.
name: Cardoso, M.-J.
name: Boyle, F.
name: Francis, P.A.
name: El Saghir, N.S.
name: Biganzoli, L.
name: Kim, S.-B.
name: Haidinger, R.
name: Lin, N.U.
name: Prat, A.
name: Bhattacharyya, G.S.
name: Harbeck, N.
name: Cardoso, F.
name: André, F.
name: Vorobiof, D.A.
name: Curigliano, G.
name: Gligorov, J.
name: Carey, L.A.
name: Cortés, J.
name: Rugo, H.S.
name: Barrios, C.H.
name: Fallowfield, L.
name: Hu, X.
name: Xu, B.
name: Paluch-Shimon, S.
name: Ohno, S.
name: Penault-Llorca, F.
name: Pagani, O.
name: Aapro, M.S.
name: Offersen, B.V.
name: Kiely, B.E.
name: Kaur, R.
name: Gelmon, K.
Publisher: name: Elsevier Ltd
Year: 2020

description: For the purpose of advanced breast cancer (ABC) guidelines, ABC comprises both inoperable locally advanced breast cancer (LABC) and metastatic breast cancer (MBC). Advanced/metastatic breast cancer remains a virtually incurable disease, with a median overall survival (OS) of about 3 years and a 5-year survival rate of around 25%, even in countries without major accessibility problems. Survival is strongly related to breast cancer subtype, with the major advances seen in human epidermal growth factor receptor 2 (HER2)-positive ABC. ABC is a treatable disease with several available therapies and many others in development. However, their impact on survival and quality of life (QoL) of ABC patients has been slow and different for de novo versus recurrent ABC, with the latter becoming much harder to treat in recent years. Outcomes are also strongly related to access to the best available care, which includes not only the most efficacious medicines, but also multidisciplinary, specialised care, implementation of guidelines, high-quality pathology, imaging and radiotherapy (RT). Lack of any of these crucial pillars of modern oncological care inevitably results in substantially worse outcomes, as exemplified in the New Zealand report “I am still here”. While mortality rates have decreased in the majority of developed countries, most deaths are currently seen in less developed societies, and access issues explain the majority of these inequalities.
One-Step Formation of Plasmonic Cu Nanodomains in p-Type Cu$_2$O Matrix Films for Enhanced Photoconversion of n-ZnO/p-Cu$_2$O Heterojunctions
Creators: name: Rodríguez-Martínez, Yerila
name: Vaillant-Roca, Lídice
name: Ghanbaja, Jaafar
name: Migot, Sylvie
name: Battie, Yann
name: Hamady, Sidi Ould Saad
name: Horwat, David
Publisher: name: arXiv
Year: 2022
Subjects: subject: Applied Physics (physics.app-ph)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Plasmonic Cu nanoparticles were in-situ grown into a Cu$_2$O semiconductor matrix by using reactive magnetron sputtering and adjusting the amount of oxygen available during the synthesis in order to prevent the oxidation of part of copper atoms landed on the film surface. Varying only the oxygen flowrate (OFR) and using a single Cu target it was possible to observe the evolution in the simultaneous formation of metallic Cu and Cu$_2$O phases for oxygen-poor conditions. Suchformation is accompanied by the development of the surface plasmon band (SPB) corresponding to Cu, as evidenced by UV-Vis spectrophotometry and spectroscopic ellipsometry. The bandgap values of the elaborated composites containing embedded Cu plasmonic nanodomains were lower than the bandgap of single-phased Cu$_2$O films, likely due to the higher defect density associated to the nanocrystalline nature of films, promoted by the presence of metallic Cu. The resistivity of the thin films increased with more oxidative deposition conditions and was associated to an increase in Cu$_2$O/Cu ratio and smaller and more isolated Cu particles, as evidenced by high resolution transmission electron microscopy and X-ray diffraction. Photoconversion devices based on the studied nanocomposites were characterized by I-V and spectral photocurrent measurements, showing an increase in the photocurrent density under light illumination as consequence of the plasmonic particles excitation leading to hot carrier's injection in the nearby ZnO and Cu$_2$O semiconductors.
description: ACS Applied Electronic Materials, American Chemical Society, 2022
Leveraging existing data to contextualize phase II clinical trial findings in oncology
Creators: name: Carey, L.A.
name: Reeder-Hayes, K.E.
name: Ray, E.M.
Publisher: name: Elsevier Ltd
Year: 2020

description: More than 250 000 women are diagnosed with early-stage breast cancer (EBC) in the USA each year. Of these, up to 30% have amplification of the human epidermal growth factor 2 (HER2). The current standard of care for HER2-positive (HER2þ) EBC is chemotherapy plus HER2-directed therapy to complete 1 year of treatment. There is growing interest in determining which patients with HER2þ tumors could achieve favorable outcomes with less chemotherapy through better HER2-targeting. The phase II Adjuvant Paclitaxel and Trastuzumab (APT) trial by Tolaney and colleagues provided compelling evidence that patients with small HER2þ tumors without nodal macrometastases can achieve highly favorable outcomes with paclitaxel and trastuzumab alone (TH), avoiding the toxicity associated with multi-agent chemotherapy regimens. Use of TH in this context has been widely adopted in the clinical setting despite the lack of a confirmatory phase III trial.
Validation of the Mayo-Portland Adaptability Inventory-4 (MPAI-4) and reference norms in a French-Canadian population with traumatic brain injury receiving rehabilitation
Creators: name: Guerrette, Marie-Claude
name: McKerral, Michelle
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: Hematology

description: Validate the factor structure and establish internal consistency reliability of the French-Canadian version of the Mayo-Portland Adaptability Inventory (MPAI-4), using a Canadian sample of adults with traumatic brain injury (TBI) receiving post-acute rehabilitation services. Psychometric analysis of French-Canadian MPAI-4 data from TBI adults (N = 1012) who received rehabilitation interventions and for whom a first French-Canadian MPAI-4 measure was completed between 2016 and 2020. Exploratory factor analysis was used to evaluate the factor structure of the French-Canadian MPAI-4. The final and best solution revealed three factors, which accounted for 48.68% of the variance. Using Cronbach’s alpha, all subscales showed good internal consistency (all 0.70 ≤ α ≤ 0.89). Reference norms for the TBI sample are provided, as well as descriptive raw data according to sex, age, TBI severity and rehabilitation setting. The French-Canadian MPAI-4 factor structure is validated. The three factors extracted are similar to the three subscales of the original MPAI-4. The questionnaire shows good psychometric properties and represents a suitable tool for TBI adults receiving rehabilitation services in a French-Canadian context. The provided reference norms will also help guide the clinical use of the MPAI-4 in French-Canadian TBI populations.Implications for rehabilitationThe MPAI-4 questionnaire measures functional abilities, global outcome and community integration following traumatic brain injury (TBI).The questionnaire can be used in inpatient, outpatient and vocational rehabilitation settings to assess TBI patients’ progress and outcomes, plan interventions and evaluate the effect of rehabilitation.The French-Canadian version of the MPAI-4 is validated and suitable to be used in French-Canadian post-acute TBI rehabilitation settings. The MPAI-4 questionnaire measures functional abilities, global outcome and community integration following traumatic brain injury (TBI). The questionnaire can be used in inpatient, outpatient and vocational rehabilitation settings to assess TBI patients’ progress and outcomes, plan interventions and evaluate the effect of rehabilitation. The French-Canadian version of the MPAI-4 is validated and suitable to be used in French-Canadian post-acute TBI rehabilitation settings.
Refractory metal coated alumina foams as support material for stem cell and fibroblasts cultivation
Creators: name: Hasemann, Georg
name: Betke, Ulf
name: Krüger, Manja
name: Walles, Heike
name: Scheffler, Michael
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: Ceramic foams
subject: Metal coating
subject: Biomaterials
subject: Tissue engineering
subject: Stem cell cultivation
subject: 621.8

description: Abstract: Ceramics are widely used as implant materials; however, they are brittle and may emit particles when used in these applications. To overcome this disadvantage, alumina foams, which represent a 3D cellular structure comparable to that of human trabecular bone structures, were sputter coated with platinum, tantalum or titanium and modified with fibronectin or collagen type I, components of the extracellular matrix (ECM). To proof the cell material interaction, the unmodified and modified materials were cultured with (a) mesenchymal stem cells being a perfect indicator for biocompatibility and releasing important cytokines of the stem cell niche and (b) with fibroblasts characterized as mediators of inflammation and therefore an important cellular component of the foreign body reaction and inflammation after implantation. To optimize and compare the influence of metal surfaces on cellular behavior, planar glass substrates have been used. Identified biocompatible metal surface of platinum, titanium and tantalum were sputtered on ceramic foams modified with the above-mentioned ECM components to investigate cellular behavior in a 3D environment. The cellular alumina support was characterized with respect to its cellular/porous structure and niche accessibility and coating thickness of the refractory metals; the average cell size was 2.3 mm, the average size of the cell windows was 1.8 mm, and the total foam porosity was 91.4%. The Pt, Ti and Ta coatings were completely dense covering the entire alumina foam surface. The metals titanium and tantalum were colonized very well by the stem cells without a coating of ECM components, whereas the fibroblasts preferred components of the ECM on the alumina foam surface.
МЕТОДИКА ПРОВЕДЕНИЯ АУДИТА ХОЗЯЙСТВЕННЫХ ОПЕРАЦИЙ ПО УЧЕТУ ОСНОВЫНХ СРЕДСТВ
Creators: name: А. А. Шаршебаев
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: аудит
учет основных средств
амортизация
экономический субъект
аудиторская деятельность

description: Статья посвящена аудиторской деятельности организаций и методике проведения хозяйственных операций. Приведена последовательность проведения аудита основных средств, а также рассмотрены инструкции проведения аудита основных средств. В результате проведения аудита основных средств, аудитор может получать необходимую информацию из документов проверяемого экономического субъекта
ОСОБЕННОСТИ УЧЕТА В МАЛЫХ ОРГАНИЗАЦИЯХ ПРИ ПЕРЕХОДЕ НА МСФО
Creators: name: Е. П. Шипунова
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: малые организации
бухгалтерская отчетность
международная система финансовой отчетности.

description: В статье рассмотрены особенности ведения бухгалтерского учета при переходе на МСФО малыми организациями. Развитие учета в соответствии с МСФО на сегодняшний день является важным фактором для успешного развития малого бизнеса. Финансирование малого бизнеса не достаточно распространены и не интересны инвесторам, так как крупный и средний бизнес является более привлекательным в получении дивидендов в короткие сроки, что работает не в пользу малого бизнеса, где извлечение прибыли, возможно, только спустя длительный промежуток времени. Одной из возможностей для развития малого бизнеса в России является использование финансирования на международном уровне, возможность получения международных тендеров и кредитов. Однако, одним из важных условий для финансирования является соответствие финансовой отчетности организаций международным стандартам.
When a climate crisis meets an energy crisis — lessons from the Australian National Electricity Market
Creators: name: Mcconnell, Dylan
name: Macgill, Iain
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 400803
subject: Electrical energy generation (incl. renewables, excl. photovoltaics)
classificationCode: 400805
subject: Electrical energy transmission, networks and systems
classificationCode: 400802
subject: Electrical circuits and systems

description: Australia is one of the world’s largest coal and liquefied natural gas (LNG) exporters, and has a power system dominated by fossil fuels. It was also an early and enthusiastic adopter of electricity market restructuring. While it remains one of the world’s most emissions-intensive electricity sectors, the Australian National Electricity Market (NEM) has also seen some of the world’s highest growth in wind and solar generation. In June 2022, the NEM was subject to an unprecedented market suspension that lasted nine days. This occurred against a backdrop of extremely high electricity prices, a largely uncoordinated energy transition, and long-running discussions on significantly reforming the structure of the market itself. This paper briefly outlines the experience of the NEM during the unfolding energy transition and the energy crisis, with a view to illuminating useful lessons and insights into the more general questions of market design and energy transition facing electricity industries around the world.
A GPU-based Correlator X-engine Implemented on the CHIME Pathfinder
Creators: name: Denman, Nolan
name: Amiri, Mandana
name: Bandura, Kevin
name: Cliche, Jean-François
name: Connor, Liam
name: Dobbs, Matt
name: Fandino, Mateus
name: Halpern, Mark
name: Hincks, Adam
name: Hinshaw, Gary
name: Höfer, Carolin
name: Klages, Peter
name: Masui, Kiyoshi
name: Parra, Juan Mena
name: Newburgh, Laura
name: Recnik, Andre
name: Shaw, J. Richard
name: Sigurdson, Kris
name: Smith, Kendrick
name: Vanderlinde, Keith
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: We present the design and implementation of a custom GPU-based compute cluster that provides the correlation X-engine of the CHIME Pathfinder radio telescope. It is among the largest such systems in operation, correlating 32,896 baselines (256 inputs) over 400MHz of radio bandwidth. Making heavy use of consumer-grade parts and a custom software stack, the system was developed at a small fraction of the cost of comparable installations. Unlike existing GPU backends, this system is built around OpenCL kernels running on consumer-level AMD GPUs, taking advantage of low-cost hardware and leveraging packed integer operations to double algorithmic efficiency. The system achieves the required 105TOPS in a 10kW power envelope, making it among the most power-efficient X-engines in use today.
description: 6 pages, 5 figures. Accepted by IEEE ASAP 2015
Performance Evaluation of Three Silicon Photomultiplier Detector Modules within the MAGIC Telescopes PMT-based camera
Creators: name: Hahn, A.
name: Mirzoyan, R.
name: Dettlaff, A.
name: Fink, D. J.
name: Mazin, D.
name: Teshima, M.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: MAGIC is a system of two imaging atmospheric Cherenkov telescopes (IACTs) located on the Canary island of La Palma. Each telescope's imaging camera consists of 1039 photomultiplier tubes (PMTs). We developed three detector modules based on silicon photomultipliers (SiPMs) of seven pixels each that are mechanically and electronically compatible with those used in the MAGIC camera. These prototype modules are installed next to the PMTs in the imaging camera and are operated in parallel. To achieve a similar active area per pixel we used seven to nine SiPMs for producing a composite pixel. The SiPM signals within one such pixel are actively summed up for retaining the fast signal pulse shapes. Two different PCB designs are tested for thermal performance. We present our simulations of Cherenkov and light of the night sky (LoNS) responses. Based on those we calculate the signal-to-noise ratio (SNR) for this imaging application. We compare our expectations with the measurements of one of the SiPM-based detector modules.
description: 18 pages, 4 figures, Proceedings of the 9th Conference on New Developments In Photodetection (NDIP20), Troyes (France), 04-08 July 2022. Published in Nuclear Instruments and Methods in Physics Research - section A (NIM-A)
TBCRC 030: a phase II study of preoperative cisplatin versus paclitaxel in triple-negative breast cancer: evaluating the homologous recombination deficiency (HRD) biomarker
Creators: name: Componeschi, K.
name: Specht, J.
name: Tung, N.
name: Krop, I.
name: Marcom, P.K.
name: Wolff, A.C.
name: Rimawi, M.
name: Trippa, L.
name: Traina, T.
name: Mayer, E.L.
name: Perou, C.
name: Abramson, V.
name: Tan-Wasielewski, Z.
name: Stearns, V.
name: Winer, E.P.
name: Timms, K.
name: Richardson, A.L.
name: Falkson, C.
name: Miller, K.
name: Carey, L.
name: Jankowitz, R.
Publisher: name: Elsevier Ltd
Year: 2020

description: Background: Cisplatin and paclitaxel are active in triple-negative breast cancer (TNBC). Despite different mechanisms of action, effective predictive biomarkers to preferentially inform drug selection have not been identified. The homologous recombination deficiency (HRD) assay (Myriad Genetics, Inc.) detects impaired double-strand DNA break repair and may identify patients with BRCA1/2-proficient tumors that are sensitive to DNA-targeting therapy. The primary objective of TBCRC 030 was to detect an association of HRD with pathologic response [residual cancer burden (RCB)-0/1] to single-agent cisplatin or paclitaxel. Patients and methods: This prospective phase II study enrolled patients with germline BRCA1/2 wild-type/unknown stage I–III TNBC in a 12-week randomized study of preoperative cisplatin or paclitaxel. The HRD assay was carried out on baseline tissue; positive HRD was defined as a score ≥33. Crossover to an alternative chemotherapy was offered if there was inadequate response. Results: One hundred and thirty-nine patients were evaluable for response, including 88 (63.3%) who had surgery at 12 weeks and 51 (36.7%) who crossed over to an alternative provider-selected preoperative chemotherapy regimen due to inadequate clinical response. HRD results were available for 104 tumors (74.8%) and 74 (71.1%) were HRD positive. The RCB-0/1 rate was 26.4% with cisplatin and 22.3% with paclitaxel. No significant association was observed between HRD score and RCB response to either cisplatin [odds ratio (OR) for RCB-0/1 if HRD positive 2.22 (95% CI: 0.39–23.68)] or paclitaxel [OR for RCB-0/1 if HRD positive 0.90 (95% CI: 0.19–4.95)]. There was no evidence of an interaction between HRD and pathologic response to chemotherapy. Conclusions: In this prospective preoperative trial in TNBC, HRD was not predictive of pathologic response. Tumors were similarly responsive to preoperative paclitaxel or cisplatin chemotherapy.
СОВЕРШЕНСТВОВАНИЕ МЕХАНИЗМА ГРАНТОВОЙ ПОДДЕРЖКИ ИНИЦИАТИВ ГРАЖДАН, ПРОЖИВАЮЩИХ В СЕЛЬСКОЙ МЕСТНОСТИ КРАСНОДАРСКОГО КРАЯ
Creators: name: Ю. А. Шолин
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: сельские территории
государственная программа
сельское развитие
сельские жители
местные инициативы
грантовая поддержка

description: В статье рассмотрены сущность и функции сельских территорий, а также их роль в социально-экономическом развитии Краснодарского края. Раскрыта сущность грантовой поддержки местных инициатив граждан как одного из эффективных инструментов устойчивого развития сельских территорий. Проанализирован действующий в Краснодарском крае механизм грантовой поддержки инициатив граждан, проживающих в сельской местности, и сформулированы основные направления его совершенствования.
Estrogen and progesterone receptor testing in breast cancer: American society of clinical oncology/college of American pathologists guideline update
Creators: name: Allison, K.H.
name: McKernin, S.E.
name: Carey, L.A.
name: Perlmutter, J.
name: Torlakovic, E.E.
name: Varella, L.
name: Weisberg, T.F.
name: Fitzgibbons, P.L.
name: Hayes, D.F.
name: Dowsett, M.
name: McShane, L.M.
name: Wolff, A.C.
name: Perou, C.M.
name: Rimm, D.L.
name: Hammond, M.E.H.
name: Chavez-MacGregor, M.
name: Viale, G.
name: Regan, M.M.
name: Lakhani, S.R.
name: Symmans, W.F.
Publisher: name: College of American Pathologists
Year: 2020

description: Purpose.-To update key recommendations of the American Society of Clinical Oncology/College of American Pathologists estrogen receptor (ER) and progesterone receptor (PgR) testing in breast cancer guideline. Methods.-A multidisciplinary international Expert Panel was convened to update the clinical practice guideline recommendations informed by a systematic review of the medical literature. Recommendations.-The Expert Panel continues to recommend ER testing of invasive breast cancers by validated immunohistochemistry as the standard for predicting which patients may benefit from endocrine therapy, and no other assays are recommended for this purpose. Breast cancer samples with 1% to 100% of tumor nuclei positive should be interpreted as ER positive. However, the Expert Panel acknowledges that there are limited data on endocrine therapy benefit for cancers with 1% to 10% of cells staining ER positive. Samples with these results should be reported using a new reporting category, ER Low Positive, with a recommended comment. A sample is considered ER negative if < 1% or 0% of tumor cell nuclei are immunoreactive. Additional strategies recommended to promote optimal performance, interpretation, and reporting of cases with an initial low to no ER staining result include establishing a laboratoryspecific standard operating procedure describing additional steps used by the laboratory to confirm/adjudicate results. The status of controls should be reported for cases with 0% to 10% staining. Similar principles apply to PgR testing, which is used primarily for prognostic purposes in the setting of an ER-positive cancer. Testing of ductal carcinoma in situ (DCIS) for ER is recommended to determine potential benefit of endocrine therapies to reduce risk of future breast cancer, while testing DCIS for PgR is considered optional. Additional information can be found at www.asco.org/breast-cancer-guidelines.
ОСОБЕННОСТИ КОРРЕКТИРОВКИ ТАМОЖЕННОЙ СТОИМОСТИ
Creators: name: А. Д. Антипова
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: внешнеэкономическая деятельность
тарифная мера
таможенная стоимость
недостоверное декларирование
внешнеторговая сделка
контракт куплипродажи
цена сделки
импорт
таможенный орган
судебная практик
обжалование

description: В данной статье рассмотрена сущность понятия корректировки таможенной стоимости товара, а также изучены условия возникновения дополнительной проверки для внесения изменений в декларации на товары. Приведена статистика судебных споров, возникающих в таможенном деле. Рассмотрены решения, вынесенные арбитражными судами, с применением положений таможенного законодательства Российской Федерации. Проанализированы основные причины возникновения споров, связанных с корректировкой таможенной стоимости.
Prognostication in post-stroke aphasia: speech pathologists’ clinical insights on formulating and delivering information about recovery
Creators: name: Cheng, Bonnie B. Y.
name: Ryan, Brooke
name: Copland, David A.
name: Wallace, Sarah J.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: For people with post-stroke aphasia, “Will I get better?” is a question often asked, but one that is intellectually and emotionally demanding for speech pathologists to answer. Speech pathologists’ formulation and delivery of aphasia prognoses is varied and there is limited evidence for optimising practice. We aimed to understand speech pathologists’ clinical experiences, reasoning, and support needs in aphasia prognostication. Twenty-five Australian speech pathologists working with people with aphasia participated in individual, semi-structured interviews. Their age, level of experience, work setting, and location were maximally varied. Interview responses were analysed qualitatively using thematic analysis. Five themes were drawn from the interviews: (1) prognostic challenges are shared but not voiced; (2) truth is there’s no quick fix; (3) recovery is more than words; (4) the power of words; and, (5) prognostic competence is implicit. Speech pathologists use implicit competencies to formulate and deliver aphasia prognoses. A patient-centred, holistic contextualisation of aphasia recovery may enable realistic, optimistic, and constructive conversations about prognosis. These conversations may have therapeutic potential if prognostic uncertainty, emotional adjustment, and conditional outcomes are carefully addressed. Future research should seek to understand the perceptions and preferences of people with aphasia and their significant others.Implications for RehabilitationAphasia prognostication in clinical practice is complex and nuanced, thus increased clinical and research focus is warranted to ensure key stakeholder needs are met.Conversations about prognosis may be more meaningful to people with aphasia if recovery is conceptualised as encompassing impairment, activity, and participation outcomes.Given the implicit competencies required for prognostication, a structured approach to reflective practice and experience-based training may be beneficial.Conversations about prognosis may have therapeutic value, but further research is needed to explore this potential. Aphasia prognostication in clinical practice is complex and nuanced, thus increased clinical and research focus is warranted to ensure key stakeholder needs are met. Conversations about prognosis may be more meaningful to people with aphasia if recovery is conceptualised as encompassing impairment, activity, and participation outcomes. Given the implicit competencies required for prognostication, a structured approach to reflective practice and experience-based training may be beneficial. Conversations about prognosis may have therapeutic value, but further research is needed to explore this potential.
Unlocking the transcriptomic potential of formalin-fixed paraffin embedded clinical tissues: Comparison of gene expression profiling approaches
Creators: name: Clark, R.
name: Sims, A.H.
name: Turnbull, A.K.
name: He, X.
name: Munro, A.F.
name: Murphy, L.
name: Keys, J.
name: Carey, L.A.
name: Renshaw, L.
name: Figueroa, J.D.
name: Perou, C.M.
name: Coutts, A.
name: Selli, C.
name: Tanioka, M.
name: Fawkes, A.
name: Dixon, J.M.
name: Fernando, A.
name: Martinez-Perez, C.
Publisher: name: BioMed Central Ltd.
Year: 2020

description: Background: High-throughput transcriptomics has matured into a very well established and widely utilised research tool over the last two decades. Clinical datasets generated on a range of different platforms continue to be deposited in public repositories provide an ever-growing, valuable resource for reanalysis. Cost and tissue availability normally preclude processing samples across multiple technologies, making it challenging to directly evaluate performance and whether data from different platforms can be reliably compared or integrated. Methods: This study describes our experiences of nine new and established mRNA profiling techniques including Lexogen QuantSeq, Qiagen QiaSeq, BioSpyder TempO-Seq, Ion AmpliSeq, Nanostring, Affymetrix Clariom S or U133A, Illumina BeadChip and RNA-seq of formalin-fixed paraffin embedded (FFPE) and fresh frozen (FF) sequential patient-matched breast tumour samples. Results: The number of genes represented and reliability varied between the platforms, but overall all methods provided data which were largely comparable. Crucially we found that it is possible to integrate data for combined analyses across FFPE/FF and platforms using established batch correction methods as required to increase cohort sizes. However, some platforms appear to be better suited to FFPE samples, particularly archival material. Conclusions: Overall, we illustrate that technology selection is a balance between required resolution, sample quality, availability and cost.
Before thy throne I slip in gently, hoping nobody will notice: A memorial to Robin Hudson
Creators: name: Gough, John
Publisher: name: arXiv
Year: 2022
Subjects: subject: History and Philosophy of Physics (physics.hist-ph)
subject: Mathematical Physics (math-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We dedicate this to the life and work of Robin Hudson -- a mathematical physicist who developed the peerless quantum stochastic calculus, but who also inspired generations of researchers with both his intellect and wit.
description: 20 pages, To appear: Infinite Dimensional Analysis, Quantum Probability and Related Topics
4th International Workshop on Camera Traps, AI, and Ecology - Presentations
Creators: name: Quigley, Cliodhna
name: Sandfort, Robin
name: Stefano, Mintchev
name: Probst, Claudia
name: Schneider, Georg
name: McKenney, Danielle
name: Tynecki, Piotr
name: Mustafic, Sead
name: Böss, Leopold
name: Wohlfahrt, Stephanie
name: Urošević, Miroslav
name: Sa'Doun, Mohammad
name: Padubidri, Chirag
name: Doll, Oliver
name: Lampesberger, Harald
name: Huber, Eva Olivia
name: Biljesko, Leo
Publisher: name: Zenodo
Year: 2024

description: Presentations of the 4th International Workshop on Camera Traps, AI, and Ecology