cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Pattern of complications and burden of disease in patients affected by beta thalassemia major
Creators: name: Bonifazi, Fedele
name: Conte, Rosa
name: Baiardi, Paola
name: Bonifazi, Donato
name: Mariagrazia Felisi
name: Giordano, Paola
name: Giannuzzi, Viviana
name: Iacono, Angela
name: Padula, Rosa
name: Pepe, Alessia
name: Putti, Maria Caterina
name: Ruggieri, Lucia
name: Vecchio, Giovanni Carlo Del
name: Filosa, Aldo
name: Maggio, Aurelio
name: Ceci, Adriana
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Marine Biology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: 110309 Infectious Diseases
subject: Computational Biology

description: Objectives: Despite the correct application of blood transfusions and chelation treatments, beta thalassemia patients have many complications. Systematic population analyses on types and frequency of these complications are very few. The aim of this study is to characterize the complications, their risk factors and their clinical and economic impact. Methods: Complications at baseline and events occurring during one observational year were analyzed in 272 patients aged >12 years. Risk factors were analyzed through chi-squared and unpaired t tests. Logistic regression was applied to perform the risk factors multivariate analysis. Results: A total of 554 complications (1–6 per patient) affected 82.3% of patients. Cardiac complications were less represented than expected. Musculoskeletal diseases were the most represented complications followed by hepatic, sexual and endocrine diseases. Splenectomized patients, born before 1970 and aged >40 years, starting iron chelation therapy when aged >4 years or after receiving more than 20 blood transfusions, presented a significantly higher number of complications. A total of 885 adverse events requiring 34125 additional medical services occurred in 1 year. Of these, 34.9% were related to treatments and 65.1% to other causes. Event numbers, additional medical interventions and cost increased progressively in patients affected by one or more complication compared to patients with no complications. Conclusions: The pattern of complications changes according to birth cohort and differentiates older from younger patients. The burden of the disease and its costs increase after the onset of the first complication, therefore prevention of complications is fundamental in these patients.
Geochronology and geochemistry of felsic xenoliths in lamprophyre dikes from the southeastern margin of the North China Craton: implications for the interleaving of the Dabie–Sulu orogenic crust
Creators: name: Wu, Fei
name: Xiao, Yilin
name: Xu, Lijuan
name: Santosh, M.
name: Li, Shuguang
name: Huang, Jian
name: Hou, Zhenhui
name: Huang, Fang
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Physiology
subject: FOS: Biological sciences

description: Lamprophyre dikes emplaced in a Jurassic granite at the southeastern margin of the North China Craton (NCC) carry different types of xenoliths. Here, we report a combined study of zircon U–Pb ages and whole-rock geochemistry of the xenoliths, as well as an Ar–Ar age of the lamprophyre, providing constraints on the sources of the magmatism and tectonic evolution in the southeastern margin of NCC. Phlogopite from the lamprophyre dike gave a 40Ar/39Ar plateau age of 116.15 ± 0.33 Ma. The felsic xenoliths can be classified into three groups: monzogranite, banded biotite granitic gneiss, and garnet-bearing gneiss. The internal structures of zircons from the banded biotite granitic gneiss xenolith show complex growth patterns. The mantles of these zircons display low luminance with a concordant SHRIMP U–Pb age of 227 ± 10 Ma. The rims with lighter luminance provide a SHRIMP U–Pb age of 213 ± 10 Ma, both ages are identical within error and significantly different from the ages of the basement rocks in the surrounding Bengbu uplift. However, the age is identical to those of the ultrahigh-pressure metamorphic rocks in the adjacent Dabie–Sulu orogen. In addition, zircon mantle domains of the banded biotite granitic gneiss xenolith have low Th/U ratios (>0.01) and flat HREE patterns ((Yb/Dy)n < 10), which suggest growth in an assemblage with garnet during HP metamorphism. The rim domains show very low Th/U ratios (<0.01) and steep HREE patterns ((Yb/Dy)n > 10), implying growth during exhumation in the absence of a garnet. Our studies show that the banded biotite gneiss represents vestiges of the subducted South China crust injected into or thrust below the North China Craton and provides constraints on the process of underthrusting in a continental collision zone, as well as the Mesozoic tectonic history of the southeastern margin of the NCC.
Reducing noise in computed correlation functions using techniques from signal processing
Creators: name: Masoori, Mohammad
name: Greenfield, Michael L.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Neuroscience
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Time correlation functions invariably suffer from random noise, especially at longer time intervals for which fewer data pairs are available. This noise is particularly of concern when calculating correlations that cannot be averaged over per-molecule contributions, such as stress in molecular simulations. In this work, a set of methods based in signal processing has been developed to reduce the inherent noise that is present in time- and frequency-domain representations of correlation functions. The stress time autocorrelation function, which leads to stress relaxation modulus and complex modulus, is used as an example. The difference between initial and final values of a time correlation function over a finite time domain is found to create so-called ‘leakage’ of noise from disallowed into harmonic frequencies during fast Fourier transformation. Decreasing this leakage effect through reflection to negative time and through applying a window function reduces noise levels significantly. Removing frequency components of insignificant magnitudes also provides significant noise reduction. Applying moving averages in the frequency and time domains also contributes to noise reduction. Specific results obtained by applying these methods to a model asphalt system enable more clear physical interpretations of the underlying relaxations after dramatic noise level reductions were attained.
Physicochemical Properties of Blends Of Flax Seed , Niger Seed & Sesame Seed Oils
Creators: name: Hiwot Dereje
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2020
Subjects: Viscosity, Refractive Index, Saponification Value, Accelerated Oxidative Stability, Blending of oil, Edible oil.

description: Today, a wide range of edible oils are available in the market but no single edible oil is
 able to meet recommendations given for healthy oil. So, blending of different edible oils is
 an emerging mechanism to develop a healthier and stable edible oil so as to satisfy
 consumer needs. Blending is an economical way of modifying the physicochemical
 characteristics besides enhancement of oxidative stability. Thus, in this study blends of
 sesame, niger and flax seed oil in different proportions were evaluated for various
 physicochemical parameters: density, viscosity, refractive index, accelerated oxidative
 stability, saponification value and peroxide value were determined using standard method
 using digital analytical balance, Brookfield RHEO meter DV3T instrument, Krusi
 Optronic, 892 professional Rancimate apparatus, AOAC official Method no. 920.160 and
 titration with Na2S2O3 solution, respectively. The density, viscosity, refractive index,
 saponification value and accelerated oxidative stability value ranged: 0.921(N12F81S7)- 0.957(N8F20S72) g/mL; 46.2(S100)-63.6(F100) centipoise; 1.473(F100)-1.482(S100); 171(N34S66)-177(N47F53) mg of KOH/g of oil; 0.874(F100)-4.697(S100) hours, respectively.
 Similarly, the peroxide value after 15, 45 and 75days of storage time were found in the range: 1.493(N34S66)-3.186 (F100), 2.469 (S100)-5.01(N12F81S7) and 3.493(S100)-7.778(F100) meq O2/kg, respectively. It was concluded that the flax seed oil has low stability was
 enhanced by addition of either of niger or sesame oil separately and by addition of sesame
 and niger oil at the same time. The best stability was seen at N8F20S72 with the mixing ratio
 of niger, flaxseed and sesame seed oil. The sensory evaluation based on the 9-hedonic scale
 were done and the results showed that wthe overall acceptance of the tested parameters
 was better in using tertiary (N8F20S72) blended oils followed by the binary blended (N34S66)
 and single flax seed oil (F100). Further study in chemical composition analysis for blended
 and none-blended oils (niger, sesame and flaxseed oil) and other types of oil which are not
 included in this study are highly recommended.
‘Mechanical restraint—confounders, risk, alliance score’: testing the clinical validity of a new risk assessment instrument
Creators: name: Nielsen, Lea Deichmann
name: Bech, Per
name: Hounsgaard, Lise
name: Gildberg, Frederik Alkier
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy
subject: Hematology

description: Background: Unstructured risk assessment, as well as confounders (underlying reasons for the patient’s risk behaviour and alliance), risk behaviour, and parameters of alliance, have been identified as factors that prolong the duration of mechanical restraint among forensic mental health inpatients. Aim: To clinically validate a new, structured short-term risk assessment instrument called the Mechanical Restraint–Confounders, Risk, Alliance Score (MR-CRAS), with the intended purpose of supporting the clinicians' observation and assessment of the patient’s readiness to be released from mechanical restraint. Methods: The content and layout of MR-CRAS and its user manual were evaluated using face validation by forensic mental health clinicians, content validation by an expert panel, and pilot testing within two, closed forensic mental health inpatient units. Results: The three sub-scales (Confounders, Risk, and a parameter of Alliance) showed excellent content validity. The clinical validations also showed that MR-CRAS was perceived and experienced as a comprehensible, relevant, comprehensive, and useable risk assessment instrument. Conclusions: MR-CRAS contains 18 clinically valid items, and the instrument can be used to support the clinical decision-making regarding the possibility of releasing the patient from mechanical restraint. Implications: The present three studies have clinically validated a short MR-CRAS scale that is currently being psychometrically tested in a larger study.
Physicochemical Properties And Biofunctional Activities of Two Monofloral Honeys From Southwest Ethiopia : The case Of Jimma Zone
Creators: name: Hawine Debela
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2020
Subjects: Biochemical, Caffeine, Coffea arabica, Glycemic index, Physicochemical property, Vernonia amygdalina

description: Honey is a sweet, viscous substance produced by honey bees from the nectar of plants or
 secretion fromplants or plant-sucking insects. Honeys from different botanical origins
 may vary in their chemical composition, flavor and color. In this study, Coffea arabica
 and Vernonia amygdalina honey of Ethiopia investigated. Moisture, sugars, electrical
 conductivity, ash, pH, free acidity, hydroxymethylfurfural, specific rotation, diastase and
 invertase activity were determined using AOAC method. Phytochemicals and antioxidant
 activities were determined using UV-visible spectrophotometer. Antibacterial activity
 determined using disc diffusion method. Sensorial analysis was done using triangle test
 panel. Glycemic index investigated using human model. Melissopalynology result showed
 thatCoffea arabica (54.4 to 94.2%) and Vernonia amygdalina (47 to 68.8%) were
 dominated honeys. It was found that Coffea arabica honey contain higher free
 acidity(33.74±5.3 meq/kg), hydroxymethylfurfural(5.6±2.52 mg/kg), Invertase activity
 (14.12±2.25 IN) andcaffeine(96.11±20.02mg/kg). The higher moisture
 (19.02±0.05g/100g), pH (4.52±0.02), specific rotation (-5.98±0.07[α]D20) and diastase
 (12.5±0.55˚schade) was found in Vernonia amygdalinahoney. Fructose was the dominant
 sugar in the monofloral honeys. Highertotal phenol (34.26±0.98 mgGAE/100g) and total
 flavonoid (93.48±1.67mgCEQ/100g) was found in Vernonia amygdalina honey and it
 showed stronger DPPH scavenging activity (45.94%) than Coffea arabica
 honey.Stronger ferric reducing antioxidant power (22.71±10 mg AAE/100g) was found in
 Coffea arabica honey. Vernonia amygdalina honey showed better inhibition against
 Staphylococcus aureus (10.21±0.89mm) and Escherichia coli (6.75±0.22mm) at 50%
 honey concentration. Based on triangle test, 94.44% of the panelist identified the bitter
 test feeling immediately after swallowing for Vernonia amygdalina honey. Coffeaarabica
 (58.5±1.8)and Vernonia amygdalina (65.4±0.75)honeyswere recorded as medium
 glycemic index foods. Based on this study, the level of caffeine and triangle test panel can
 possibly use to differentiate Coffea arabica and Vernonia amygdalina honey, and all the
 monofloral honeys satisfy the standards of Codex Alimentarius.
Additional file 5 of In silico evolution of Aspergillus niger organic acid production suggests strategies for switching acid output
Creators: name: Upton, Daniel
name: McQueen-Mason, Simon
name: A. Wood
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Additional file 5: Table S15. Index numbers of mutations and corresponding reactions and mutation effects.
Physicochemical & Biofunctional Properties of Propolis from Selected Areas Of Ethiopia
Creators: name: Mitiku Diriba
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2020

description: Propolis is one of the natural hive products and a sticky material mixed by honeybees to
 utilize it in protecting their hives from infection by bacteria and fungi. The objectives of
 this study were to investigate the physicochemical and biofunctional properties of
 propolis collected from three different parts of Ethiopia (Asela, Sheka and Gambela).
 Physicochemical properties determined using analytical method, antibacterial
 examination using disc diffusion method, antioxidant properties examined using
 spectrophotometric method, and Rodent model was used to investigate the healing effect
 of propoliss. The result showed that propolis from Gambella contains phenolic content
 significantly greater than propolis from Sheka and Asela. Inhibition concentration of 50
 %( IC50) of DPPH for Gambella was (22.1 µg/ml), (18.1 µg/ml) for Asela and (12.2
 µg/ml) for Sheka propolis, (15.2µg/ml) for Ascorbic acid as positive control. Concerning
 antimicrobial activities of propolis, the minimum and maximum zone of inhibition for
 water extracts (at 10 & 30% concentration) for the three propolis samples was 7.15 and
 9.50mm respectively for E. coli and 6.55 and 10.21mm for S. aureus, respectively. But for
 ethanol extract the zone of inhibition was significantly higher than water exract, 7.09 and
 10.64mm for E. coli and 8.69 and 12.06mm for S. aureus. Mineral analyzed from
 propolis was classified as essential microelements (, potassium contents in the sample
 ranges from 0.16% - 0.35%, magnesium 0.15% - 0.35%, calssium 0.24% - 0.36%) and
 essential trace elements (Iron ranges from 0.001% - 0.22%, and Zinc from 0.00% - 0.
 02%). The wound contracting (improving) abilities of 10% extract ointments (Propolis +
 petroleum jells) for Asela, Sheka and Gambella at 14th day was (83.75%, 80.88%,
 84.48% respectively) significantly (P < 0.05) greater than that of the control (42.11% for
 wounded and not get any treatment and 41.97% for petroleum jell) but there was no
 signifance difference between Asela and Standard ointment (Nitrofurazone) at 14th days
 of wound improve. These results indicate that propolis collected from Ethiopia had an
 antioxidant activity, source of essential elements, and the ability to inhibit microbes.
 These, properties can be a good candidate in food, pharmaceutical industries and
 traditional healing practices
Aromatic components produced by non-Saccharomyces Cerevisiae derived from natural fermentation of grape
Creators: name: Shi, Xuewei
name: Chen, Fusheng
name: Xu, Ya'nan
name: Zheng, Xiaoji
name: Xiao, Jing
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Molecular Biology
subject: Microbiology
subject: Biochemistry

description: Aromatic components are important functional products during the wine fermentation process. In the current study, nine strains (Y10, Y5, Y21, Y2, Y19, Y16, Y3, Y13 and Y4) of non-Saccharomyces were isolated from Cabernet Sauvignon grape wine. Aromatic components from Cabernet sauvignon-fermented wine were determined the phylogenetic evolution status of different non-Saccharomyces based on 26S rDNA and D1/D2 sequence analysis and analysed by a gas chromatography–mass spectrometry analysis, and they were grouped into one category with four different yeast genus which were Meyerozyma guilliermondii, Brettanomyces naardenensis, Pichia guilliermondi and Candida fermentati. A total of 102 kinds of aroma components were detected, including 39 kinds of esters, 31 kinds of alcohols, 8 kinds of ketones, 10 kinds of alkanes, 15 kinds of acids and 4 kinds of other aroma substances.
Complications pattern and burden of the disease in patients affected by beta-thalassaemia major
Creators: name: Bonifazi, Fedele
name: Conte, Rosa
name: Baiardi, Paola
name: Bonifazi, Donato
name: Mariagrazia Felisi
name: Giordano, Paola
name: Giannuzzi, Viviana
name: Iacono, Angela
name: Padula, Rosa
name: Pepe, Alessia
name: Putti, Maria Caterina
name: Ruggieri, Lucia
name: Vecchio, Giovanni Carlo Del
name: Filosa, Aldo
name: Maggio, Aurelio
name: Ceci, Adriana
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Science Policy
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Objectives: Despite the correct application of blood transfusions and chelation treatments, beta-thalassaemia patients have many complications. Systematic population analyses on types and frequency of these complications are very few. The aim of this study is to characterize the complications,their risk factors and their clinical and economic impact. Methods: Complications at baseline and events occurred during 1 observational year were analysed in 272 patients aged >12 years. Risk factors were analysed through chi-squared and unpaired t-tests. Logistic regression was applied to perform the risk factors multivariate analysis. Results: 82.3% of patients were affected by 1 to 6 complications for a total of 554. Cardiac complications were less represented than expected. Musculoskeletal diseases have been the most represented complications followed by hepatic, sexual and endocrine diseases. Splenectomised patients, born before 1970 and aged >40 years, starting iron chelation therapy when aged >4 years or after receiving more than 20 blood transfusions presented a significantly higher number of complications. 885 adverse events requiring 3425 additional medical services occurred in 1 year. Of these, 34.9% were related to treatments and 65.1% to other causes. Events number, additional medical intervention and costs increase progressively in patients that are affected by 1 complication or more with respect to patients with no complications. Conclusions: The pattern of complications is changing according to the birth cohort and differentiates the older from the younger patients. The burden of the disease and its costs increase after the onset of the first complication, therefore prevention of complications is fundamental in these patients.
New sesquiterpenoid derivatives from Solanum septemlobum with cytotoxicities
Creators: name: Zhang, Lei
name: Lin, Hai-Qing
name: Li, Gui-Sheng
name: Yue, Xi-Dian
name: Dai, Sheng-Jun
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Cancer
Biological Sciences
Chemistry
Earth and Environmental Sciences
Biotechnology
Engineering
Biochemistry

description: Two new sesquiterpenoid derivatives, attributable to eudesmane-type (1–2, named septemlobin D and 11,12-O-isopropylidenesolajiangxin F), were isolated from the whole plant of Solanum septemlobum. Their structures were elucidated on the basis of integrated spectroscopic techniques, mainly HR-FAB-MS, 1D and 2D-NMR (1H–1H COSY, HMQC, HMBC and ROESY). In vitro, two sesquiterpenoid derivatives were found to show significant cytotoxicity against three cancer cell lines (P-388, HONE-1 and HT-29), and gave IC50 values in the range of 3.0–7.3 μM.
Additional file 6 of In silico evolution of Aspergillus niger organic acid production suggests strategies for switching acid output
Creators: name: Upton, Daniel
name: McQueen-Mason, Simon
name: A. Wood
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 6. The file provides the additional Figures S1â€“S15.
Heteroleptic ruthenium(II)/(III) 2,2′-bipyridine/1,10-phenanthroline complexes incorporating bidentate Schiff base N,O-ligands
Creators: name: Chang-Jiu Wang
name: Xu, Wen-Fang
name: Bi-Hai Tong
name: Ai-Quan Jia
name: Zhang, Qian-Feng
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer

description: Eight substituted bidentate Schiff base ligands HOC6H4CH=N-R (HL) (HL1: R = 4-ClC6H4, HL2: R = 2-ClC6H4, HL3: R = 4-NO2C6H4, HL4: R = 4-MeC6H4, HL5: R = 2,6-Me2C6H3, HL6: R = 2,46-Me3C6H2, HL7: R = CH2C6H5, and HL8: R = n-Pr) were synthesized by the typical condensation reaction. Interaction of cis-[Ru(bpy)2Cl2]⋅2H2O (bpy = 2,2′-bipyridine) with one equivalent of HL ligand in the presence of KPF6 afforded the cationic ruthenium(II) complexes of the type [Ru(bpy)2(L)](PF6) (1–8). The reaction of cis-[Ru(phen)2Cl2]⋅2H2O (phen = 1,10-phenanthroline) and HL1 under similar condition gave complex [(phen)2Ru(L)](PF6) (1a). Treatment of cis-[Ru(phen)2Cl2]⋅2H2O with two equivalents of HL in the presence of KPF6 resulted in isolation of the cationic ruthenium(III) complexes of the type [Ru(phen)(L)2](PF6) (9-16). All complexes have been spectroscopically characterized. The structures of 1a⋅CH2Cl2, 2⋅½CH2Cl2, 3⋅CH3CN, 5⋅½H2O, 6, 12⋅½HOCH2CH2OH, 13⋅CH3CN, 15⋅H2O, and 16 have been determined by single-crystal X-ray diffraction.
First Donor-Stabilized Complexes of Manganese(II) with Disubstituted diphenyldithiophosphates: synthesis, characterization, biological, and X-ray Analysis
Creators: name: Sajgotra, Mehak
name: Khajuria, Ruchi
name: Kumar, Sandeep
name: Syed, Atiya
name: Andotra, Savit
name: Kour, Gurvinder
name: Gupta, Vivek K.
name: Kant, Rajni
name: Pandey, Sushil K.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Chemistry
subject: Cell Biology

description: GRAPHICAL ABSTRACT
First Donor Stabilized Complexes of Manganese(ii) with Disubstituted Diphenyldithiophosphates: Synthesis, Characterization, Biological and X-ray Analysis
Creators: name: Sajgotra, Mehak
name: Khajuria, Ruchi
name: Kumar, Sandeep
name: Syed, Atiya
name: Andotra, Savit
name: Kour, Gurvinder
name: Gupta, Vivek K.
name: Kant, Rajni
name: Pandey, Sushil K.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Chemistry
subject: Cell Biology

description: The complexes [{(ArO)2PS2}2Mn(NC5H5)2] (1-4) [(Ar = 2,4-(CH3)2C6H3(1), 2,5-(CH3)2C6H3(2), 3,4-(CH3)2C6H3(3) and 3,5-(CH3)2C6H3) (4)] have been isolated in aqueous medium and characterized by mass spectrometer, IR, magnetic susceptibility and single crystal X-ray analyses. The complex [{(2,4-(CH3)2C6H3O)2PS2)}2Mn(NC5H5)2] (1) crystallizes in the monoclinic space group P21/n as a monomer with a basic core of the four-membered ring [MnS4]. The octahedral sphere of the Mn atom is completed by donation from the nitrogen atoms of the two pyridine rings and four sulfur atoms of the dithio moiety. The thermal gravimetric analysis of the complex (1) revealed the end product as MnS. Screening of the ligands and complexes against the fungus Fusarium oxysporum has indicated potential antifungal activity.
An illustration of the upper bound U on the Regularization Constant for Convex Sparse Signal Reconstruction
Creators: name: Dogandzic, Aleksandar
name: Renliang Gu
Publisher: name: figshare
Year: 2017
Subjects: subject: 10303 Optimisation
subject: FOS: Mathematics
subject: 90609 Signal Processing
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: An illustration of the upper bound U and minimum sets Xu, Q, and X⋄.
Additional file 7 of In silico evolution of Aspergillus niger organic acid production suggests strategies for switching acid output
Creators: name: Upton, Daniel
name: McQueen-Mason, Simon
name: A. Wood
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 7. Full derivation of the fitness function used for in silico evolution of organic acid production.
Additional file 1 of Practitioner perspectives on building capacity for evidence-based public health in state health departments in the United States: a qualitative case study
Creators: name: Mazzucca, Stephanie
name: Valko, Cheryl
name: Eyler, Amy
name: Macchi, Marti
name: Lau, Andrew
name: Alongi, Jeanne
name: Robitscher, John
name: Brownson, Ross
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Additional file 1. Interview guide
Additional file 2 of Practitioner perspectives on building capacity for evidence-based public health in state health departments in the United States: a qualitative case study
Creators: name: Mazzucca, Stephanie
name: Valko, Cheryl
name: Eyler, Amy
name: Macchi, Marti
name: Lau, Andrew
name: Alongi, Jeanne
name: Robitscher, John
name: Brownson, Ross
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Computational Biology

description: Additional file 2. Coding Tree
Additional file 3 of Practitioner perspectives on building capacity for evidence-based public health in state health departments in the United States: a qualitative case study
Creators: name: Mazzucca, Stephanie
name: Valko, Cheryl
name: Eyler, Amy
name: Macchi, Marti
name: Lau, Andrew
name: Alongi, Jeanne
name: Robitscher, John
name: Brownson, Ross
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Additional file 3. Reporting Checklist
First Donor-Stabilized Complexes of Manganese(II) with Disubstituted Diphenyldithiophosphates: Synthesis, Characterization, Biological, and X-ray Analysis
Creators: name: Sajgotra, Mehak
name: Khajuria, Ruchi
name: Kumar, Sandeep
name: Syed, Atiya
name: Andotra, Savit
name: Kour, Gurvinder
name: Gupta, Vivek K.
name: Kant, Rajni
name: Pandey, Sushil K.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Chemistry
subject: Cell Biology

description: GRAPHICAL ABSTRACT
Supplementary Material for: Spironolactone for the Treatment of Acne: A 4-Year Retrospective Study
Creators: name: Grandhi, R.
name: Alikhan, A.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Prior studies have demonstrated that spironolactone is an effective second-line treatment option for postadolescent acne, but has notable side effects. Data are, however, limited. We therefore present a 4-year retrospective study evaluating 291.5 patient-years of spironolactone for the treatment of acne. Our results showed that 86% of patients improved on spironolactone therapy. Further, patients who improved showed minimal side effects, supporting recent evidence that spironolactone is a safe option for acne treatment with a low risk of short-term adverse effects such as hyperkalemia. It is suggested that our study encourages consideration of spironolactone for postadolescent acne.
Supplementary Material for: Role of Organic Anion Transporters in the Uptake of Protein-Bound Uremic Toxins by Human Endothelial Cells and Monocyte Chemoattractant Protein-1 Expression
Creators: name: Favretto, G.
name: Souza, L.M.
name: Gregório, P.C.
name: Cunha, R.S.
name: R.A.P., Maciel
name: Sassaki, G.L.
name: Toledo, M.G.
name: Pecoits-Filho, R.
name: Souza, W.M.
name: Stinghen A.E.M.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Organic anion transporters (OATs) are involved in the uptake of uremic toxins such as p-cresyl sulfate (PCS) and indoxyl sulfate (IS), which play a role in endothelial dysfunction in patients with chronic kidney diseases (CKD). In this study, we investigated the role of OAT1 and OAT3 in the uptake of PCS and IS into human endothelial cells. PCS was synthesized via p-cresol sulfation and characterized using analytical methods. The cells were treated with PCS and IS in the absence and presence of probenecid (Pb), an OAT inhibitor. Cell viability was assessed using the MTT assay. The absorbed toxins were analyzed using chromatography, OAT expression using immunocytochemistry and western blot, and monocyte chemoattractant protein-1 (MCP-1) expression using enzyme-linked immunosorbent assay. Cell viability decreased after toxin treatment in a dose-dependent manner. PCS and IS showed significant internalization after 60 min treatment, while no internalization was observed in the presence of Pb, suggesting that OATs are involved in the transport of both toxins. Immunocytochemistry and western blot demonstrated OAT1 and OAT3 expression in endothelial cells. MCP-1 expression increased after toxins treatment but decreased after Pb treatment. PCS and IS uptake were mediated by OATs, and OAT blockage could serve as a therapeutic strategy to inhibit MCP-1 expression.
Supplementary Material for: Complement C3 Expression Is Decreased in Autism Spectrum Disorder Subjects and Contributes to Behavioral Deficits in Rodents
Creators: name: Fagan, K.
name: Crider, A.
name: Ahmed, A.O.
name: Pillai, A.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with hallmark symptoms including social deficits, communication deficits and repetitive behaviors. Accumulating evidence suggests a potential role of the immune system in the pathophysiology of ASD. The complement system represents one of the major effector mechanisms of the innate immune system, and regulates inflammation, and orchestrates defense against pathogens. However, the role of CNS complement system in ASD is not well understood. In the present study, we found a significant increase in C2, C5, and MASP1, but a decrease in C1q, C3, and C4 mRNA levels in the middle frontal gyrus of ASD subjects compared to controls. Significant decreases in the mRNA levels of 2 key proinflammatory cytokines, IL-17 and IL-23 were observed in ASD subjects. Our study further demonstrated a strong association of complement genes with IL-17 and IL-23, suggesting a possible role of the complement system in immune dysregulation in ASD. We observed significant associations between complement components and abnormality of development scores in subjects with ASD. In rodents, C3 knockdown in the prefrontal cortex induced social interaction deficits and repetitive behavior in mice. Together, these studies suggest a potential role of C3 in the pathophysiology of ASD.
Importance Sampling for Reliability Evaluation with Stochastic Simulation Models
Creators: name: Choe, Youngjun
name: Byon, Eunshin
name: Chen, Nan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Mathematics
subject: FOS: Mathematics
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Genetics
subject: Engineering

description: Importance sampling has been used to improve the efficiency of simulations where the simulation output is uniquely determined, given a fixed input. We extend the theory of importance sampling to estimate a system's reliability with stochastic simulations. Thanks to the advance of computing power, stochastic simulation models are employed in many applications to represent a complex system behavior. In a stochastic simulation model, a simulator generates stochastic outputs at the same input. Given a budget constraint on total simulation replications, we develop a new approach, which we call stochastic importance sampling, that efficiently uses stochastic simulations with unknown output distribution. Specifically, we derive the optimal importance sampling density and allocation procedure that minimize the variance of an estimator. Application to a computationally intensive aeroelastic wind turbine simulation demonstrates the benefits of the proposed approach.
An illustration of the upper bound U on the regularization constant for convex sparse signal reconstruction
Creators: name: Dogandzic, Aleksandar
name: Renliang Gu
Publisher: name: figshare
Year: 2017
Subjects: subject: 10303 Optimisation
subject: FOS: Mathematics
subject: 90609 Signal Processing
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: An illustration of the upper bound U and minimum sets Xu, Q, and X⋄.
Regularized Semiparametric Estimation for Ordinary Differential Equations
Creators: name: Li, Yun
name: Zhu, Ji
name: Wang, Naisyin
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Biotechnology

description: Ordinary differential equations (ODEs) are widely used in modeling dynamic systems and have ample applications in the fields of physics, engineering, economics, and biological sciences. The ODE parameters often possess physiological meanings and can help scientists gain better understanding of the system. One key interest is thus to well estimate these parameters. Ideally, constant parameters are preferred due to their easy interpretation. In reality, however, constant parameters can be too restrictive such that even after incorporating error terms, there could still be unknown sources of disturbance that lead to poor agreement between observed data and the estimated ODE system. In this article, we address this issue and accommodate short-term interferences by allowing parameters to vary with time. We propose a new regularized estimation procedure on the time-varying parameters of an ODE system so that these parameters could change with time during transitions but remain constants within stable stages. We found, through simulation studies, that the proposed method performs well and tends to have less variation in comparison to the nonregularized approach. On the theoretical front, we derive finite-sample estimation error bounds for the proposed method. Applications of the proposed method to modeling the hare–lynx relationship and the measles incidence dynamic in Ontario, Canada lead to satisfactory and meaningful results. Supplementary materials for this article are available online.
Regularized Semiparametric Estimation for Ordinary Differential Equations
Creators: name: Li, Yun
name: Zhu, Ji
name: Wang, Naisyin
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Biotechnology

description: Ordinary differential equations (ODEs) are widely used in modeling dynamic systems and have ample applications in the fields of physics, engineering, economics and biological sciences. The ODE parameters often possess physiological meanings and can help scientists gain better understanding of the system. One key interest is thus to well estimate these parameters. Ideally, constant parameters are preferred due to their easy interpretation. In reality, however, constant parameters can be too restrictive such that even after incorporating error terms, there could still be unknown sources of disturbance that lead to poor agreement between observed data and the estimated ODE system. In this paper, we address this issue and accommodate short-term interferences by allowing parameters to vary with time. We propose a new regularized estimation procedure on the time-varying parameters of an ODE system so that these parameters could change with time during transitions but remain constants within stable stages. We found, through simulation studies, that the proposed method performs well and tends to have less variation in comparison to the non-regularized approach. On the theoretical front, we derive finite-sample estimation error bounds for the proposed method. Applications of the proposed method to modeling the hare-lynx relationship and the measles incidence dynamic in Ontario, Canada lead to satisfactory and meaningful results.
Two Zn(II) coordination polymers based on 1,3-di(4’-carboxyl-phenyl)benzene and N-donor coligands: syntheses, crystal structures, and luminescent properties
Creators: name: Liu, Bing
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Biological Sciences
subject: Chemistry
subject: Medicine
subject: Physics
subject: Biochemistry
subject: Biophysics

description: Two coordination polymers, {[Zn(dpb)(3-bpmp)0.5]·1.5(DMF)}n (1) and [Zn(dpb)(4-bpmp)]n (2) (H2dpb = 1,3-di(4′-carboxyl-phenyl)benzene, 3-bpmp = 1,4-bis(3-pyridylmethy)piperazine, 4-bpmp = 1,4-bis(4-pyridylmethy)piperazine and DMF = N,N-dimethylformamide), were solvothermally synthesized and characterized. Tuning the difference of N-donor ligands, we obtained 1 and 2 which display different topological nets. Complex 1 features a 6-connected topological net and 2 shows a 4-connected three-fold interpenetrated framework. Luminescent properties of 1 and 2 are investigated at room temperature.
Development of a Strategic DSTfor PCN
Creators: name: Kleczkowski, Adam
name: Jones, Glyn
name: Pickup, Jon
name: McDougal, Beth
Publisher: name: Zenodo
Year: 2022

description: •Can we quantify the impact of PCN on the industry? •What will happen if the current trend persists? •What will the economic impact be? •What is the impact of possible control strategies?
Two Zn(II) coordination polymers based on 1,3-di(4’-carboxyl-phenyl)benzene and N-donor coligands: Syntheses, crystal structures and luminescent properties
Creators: name: Liu, Bing
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Biological Sciences
subject: Chemistry
subject: Medicine
subject: Physics
subject: Biochemistry
subject: Biophysics

description: Two coordination polymers, {[Zn(dpb)(3-bpmp)0.5]·1.5(DMF)}n (1) and [Zn(dpb)(4-bpmp)]n (2) (H2dpb = 1,3-di(4’-carboxyl-phenyl)benzene, 3-bpmp = 1,4-bis(3-pyridylmethy)piperazine, 4-bpmp = 1,4-bis(4-pyridylmethy)piperazine and DMF = N,N-dimethylformamide), were solvothermally synthesized and characterized. Tuning the difference of N-donor ligands, we obtained 1 and 2 which display different topological nets. Complex 1 features a 6-connected topological net and 2 shows a 4-connected three-fold interpenetrated framework. Luminescent properties of 1 and 2 are investigated at room temperature.
Mesozoic evolution of NW Africa: implications for the Central Atlantic Ocean dynamics
Creators: name: Leprêtre, Rémi
name: Barbarand, Jocelyn
name: Missenard, Yves
name: Gautheron, Cécile
name: Pinna-Jamme, Rosella
name: Saddiq, Omar
Publisher: name: Geological Society of London
Year: 2017
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: The method for thermal modelling, the thermal modelling for all samples and the relationship between apatite chemistry.
Additional file 1 of A multiple-behaviour investigation of goal prioritisation in physicians receiving audit and feedback to address high-risk prescribing in nursing homes
Creators: name: McCleary, Nicola
name: Desveaux, Laura
name: Reis, Catherine
name: Linklater, Stefanie
name: Witteman, Holly
name: Taljaard, Monica
name: Kednapa Thavorn
name: Grimshaw, Jeremy
name: Ivers, Noah
name: Presseau, Justin
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1. Good Reporting of A Mixed Methods Study (GRAMMS) Checklist.
Additional file 1 of Validity and reliability of a dish-based semi-quantitative food frequency questionnaire for assessment of energy and nutrient intake among Iranian adults
Creators: name: Doustmohammadian, Azam
name: Amini, Maryam
name: Esmaillzadeh, Ahmad
name: Omidvar, Nasrin
name: Abtahi, Mitra
name: Monireh Dadkhah-Piraghaj
name: Nikooyeh, Bahareh
name: Tirang Neyestani
Publisher: name: figshare
Year: 2020
Subjects: subject: Space Science
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology

description: Additional file 1: Figure S1. Sampling process of the study subjects for developing the DFFQ. Sampling process.
Site-specific Cultural Infrastructure utilising Raspberry Pi Computers to bridge the Digital Divide.
Creators: name: Steyn, Juan
name: Goodrich, Andre
name: Tempelhof, Gustaf
Publisher: name: figshare
Year: 2017
Subjects: Digital Humanities

description: Utilising small format or single board computers such as the Raspberry Pi to create sustainable cultural infrastructure and conquer the digital divide.
 p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; text-align: justify; font: 16.0px Arial} span.s1 {font-kerning: none} The ability to create and deploy networking technologies able to deliver relevant content over multiple platforms has until very recently depended on access to costly technology, infrastructure and expertise. The result has been a digital divide that is particularly acute in highly unequal economic contexts like South Africa. The potential of ICT to democratize the public realm, currently dominated by large media houses catering to individuals with the economic means to access costly data services, has not been realized.
Syntheses, structures, and properties of two- and three-dimensional coordination polymers based on bis(imidazole) and glutarate ligands
Creators: name: Yang, Zhi
name: Han, Shan-Shan
name: Zheng, Ling-Yun
name: Peng, Yan-Fen
name: Li, Bao-Long
name: Li, Hai-Yan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Biotechnology
Cell Biology
Physics
Biochemistry
Biophysics

description: Two new coordination polymers, [Zn(bix)0.5(glu)]n (1) and {[Co(bix)(glu)]·4H2O}n (2), were synthesized (bix = 1,4-bis(2-methylimidazol-1-ylmethyl)benzene, glu = glutarate). In 1, each Zn(II) is connected by four glu ligands and extend to form a [Zn(glu)]n 2-D network. Adjacent [Zn(glu)]n 2-D networks are bridged by bix ligands to construct a 6-connected 3-D network based on the Zn2 unit. 2 shows an undulated 2-D (4,4) network. The interesting structural feature of 2 is that there are 1-D water chains. The O–H···O hydrogen bond interactions link the 2-D coordination networks and construct the 3-D supramolecular architecture in 2. The glu ligands are bis-(bidentate) bridges in 1 and bis-(monodentate) bridges in 2. The luminescence of 1 and thermal stability of 1 and 2 were investigated.