cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Determining the function of the TRAMP complex subunit Air1 and the Protein Phosphatase 2A subunit Pab1 in the flocculation of Schizosaccharomyces pombe
Creators: name: Shah, Farah N
Publisher: name: Science
Year: 2022
Subjects: subject: Flocculation
subject: Schizosaccharomyces pombe
subject: TRAMP complex
subject: Protein phosphatase 2A
subject: Biological Sciences

description: Flocculation is a calcium dependent stress response characterized by the asexual aggregation of yeast cells into flocs in liquid medium. It is a reversible process that occurs in response to various environmental stressors and is induced to protect the yeast cells present in the inner-most center of the flocs. Flocculation is a highly valuable trait that exhibits a wide variety of yeast industry applications. As much of the post-transcriptional and post-translational regulatory network governing flocculation in Schizosaccharomyces pombe remains uncharacterized, we employed a reverse genetics approach in an attempt to identify novel regulators of flocculation. Results revealed that deletion of air1+ and pab1+ leads to a flocculation phenotype observed in non-inducing growth conditions. Based on these preliminary results, we reasoned that the Air1 RNA-binding component of the TRAMP complex and the Pab1 regulatory subunit of PP2A may function as negative regulators of flocculation. In this study, we have shown a potential role of the TRAMP complex and protein phosphatase 2A in the post-transcriptional and post- translational flocculation regulatory network, respectively. We have successfully identified some of the genes required for the constitutive flocculation phenotype of air1? and pab1? mutants. We have also provided evidence of gsf2+, mbx2+, cbf12+ and pfl9+ upregulation in the air1? strain using qPCR. Lastly, we have identified Sds23 as an upstream positive regulator of flocculation possibly involved in the inhibition of PP2A function and determined that the Lkh1 kinase may function upstream of Pab1 in the flocculation regulatory network. Although the regulatory pathway governing flocculation is quite extensive, we have identified key players in the flocculation network and have laid the groundwork for future analysis.
Para una aproximación a la (r)evolución del discurso político latinoamericano desde Fidel Castro hasta Rafael Correa
Creators: name: Bajini, Irina
Publisher: name: Università degli  Studi di Milano
Year: 2010
Subjects: latinoamérica; discurso político; ideología; revolución; indígena; pueblo; bolivariano; ciudadano

description: This article tries to place and characterize the latinoamerican political discourse. The analyses of some cases (Fidel Castro, Hugo Chávez, Fernando Lugo, Rafael Correa, Evo Morales and Luiz Inácio Lula da Silva) contain verbal and gestual elements, and the persuasive consequences of political discourse.
description: Altre Modernità, No 3 (2010): Comunicare le passioni: la costruzione dello spazio politico
Gender identity and in/fertility
Creators: name: Walks, Michelle
Publisher: name: University of British Columbia
Year: 2013

description: Pregnancy is considered a feminine experience in mainstream Canadian culture. Babies identified as female at birth are expected to grow up to become feminine heterosexual mothers. This research considers the desires, choices, and experiences of individuals who were identified as female at birth, but who do not identify as feminine heterosexual women; this dissertation focuses on the reproductive desires, choices, and experiences of butch lesbians, transmen, and genderqueer individuals in British Columbia. Three methods and two distinct populations formed this research. Participant observation was conducted in 21 cities across southern BC. Questionnaires were completed by 28 health care professionals (HCPs), and by 46 butch lesbian, transmen, and genderqueer (BTQ) individuals. Face-to-face interviews were conducted with 10 HCPs, 8 BTQ individuals who had experienced at least one successful pregnancy, and 4 BTQ individuals who had either experienced or been diagnosed with a condition linked to infertility. What I found, is that for many BTQ individuals, reproduction associated with the female body (ie: pregnancy and breastfeeding) is not exclusively considered a feminine desire or experience. In fact, what I discovered is that BTQ individuals who experience pregnancy and breastfeeding explicitly challenge the cultural fetish associating femininity with reproduction (including pregnancy, breastfeeding, mothering, and fertility). Thus, I highlight not only the typically ignored desire and achievement of pregnancy of BTQ individuals, but also how BTQ individuals have experienced breastfeeding, how some BTQ parents raise queerlings, and how some BTQ individuals have negotiated diagnoses and experiences of infertility. Overall, I highlight the unique and various expectations and experiences that butch lesbians, transmen, and genderqueer individuals have regarding their ‘female’ (and potential) biological reproduction. In the end, I hope that by presenting the diverse reproductive experiences, desires, and choices of BTQ individuals, that I can foster more of an understanding of these experiences, desires, choices, and individuals, and thus challenge the cultural fetish that links femininity with ‘female’-associated reproduction. Moreover, I offer recommendations for health care professionals in an effort to foster more understanding in BTQ health care, as well as help to facilitate more queer competent health care professionals.
Tra storia e mito. Politiche e usi politici di Abraham Lincoln
Creators: name: Sioli, Marco
Publisher: name: Università degli  Studi di Milano
Year: 2010
Subjects: Stati Uniti; Guerra d’indipendenza; Mito dell’Indipendenza; Abraham Lincoln; Barack Obama

description: Barack Obama's election brought to the forefront one of the key figures of the nineteenth century, Abraham Lincoln, considered to be a founder of the nation by the new American President. Like Lincoln, Obama put the accent on unity and national goodwill. Like Lincoln, Obama nourished the roots that connected to the common man. The deep desire for change in American politics that Obama espouses also occurred during Lincoln's presidency.

This essay dwells on Lincoln's words that are impressive in many respects, especially in the way they are able to communicate the passion of political involvement, as well as are impressive the images which represent the Great Emancipator in the different period of American history. Words and images reinterpreted Lincoln's myth in a contemporary mood, showing the how Lincoln became a continuously changing icon, down to the current presidency of Barack Obama.
description: Altre Modernità, No 3 (2010): Comunicare le passioni: la costruzione dello spazio politico
Atomic-scale confinement of optical fields
Creators: name: Kern, Johannes
name: Grossmann, Swen
name: Tarakina, Nadezda V.
name: Häckel, Tim
name: Emmerling, Monika
name: Kamp, Martin
name: Huang, Jer-Shing
name: Biagioni, Paolo
name: Prangsma, Jord C.
name: Hecht, Bert
Publisher: name: arXiv
Year: 2011
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: In the presence of matter there is no fundamental limit preventing confinement of visible light even down to atomic scales. Achieving such confinement and the corresponding intensity enhancement inevitably requires simultaneous control over atomic-scale details of material structures and over the optical modes that such structures support. By means of self-assembly we have obtained side-by-side aligned gold nanorod dimers with robust atomically-defined gaps reaching below 0.5 nm. The existence of atomically-confined light fields in these gaps is demonstrated by observing extreme Coulomb splitting of corresponding symmetric and anti-symmetric dimer eigenmodes of more than 800 meV in white-light scattering experiments. Our results open new perspectives for atomically-resolved spectroscopic imaging, deeply nonlinear optics, ultra-sensing, cavity optomechanics as well as for the realization of novel quantum-optical devices.
Investigating the potential of using low-intensity ultrasound on skin cells for facial skin cancer treatment
Creators: name: Mohammadi Jahromi, Seyed Mohammad
Publisher: name: Schulich School of Engineering
Year: 2022
Subjects: subject: non-invasive skin cancer treatment
subject: Ultrasound therapy
subject: crystal emitter
subject: acoustic pressure measurement
subject: acoustic pressure simulation
subject: acoustic pressure field
subject: ultrasound cell exposure device
subject: Health Sciences--General
subject: Health Sciences--Medicine and Surgery
subject: Health Sciences--Oncology
subject: Engineering--Biomedical

description: Skin cancer is one of the most prevalent cancers. This type of cancer usually occurs in a body region often exposed to the sun. Current treatments such as surgery, radiotherapy, and photodynamic therapy can be painful and have aesthetic side effects about which most patients complain. Furthermore, the chance of skin cancer recurrence is high. As a non-invasive cancer treatment, ultrasound has the potential to be used for skin cancer treatment. Since skin cancer occurs at the surface, it does not need complex imaging to localize the tumour, and the treatment usually does not take long. Investigating the effect of ultrasound on skin cells is a critical step in understanding the effect of ultrasound on skin cancer. This thesis focuses on investigating the potential of using low-intensity ultrasound on skin cells and proposes designs for facial skin cancer treatment. First, as a starting point of the project, an ultrasound device used for dermal cosmetic purposes was acoustically and electrically characterized. Second, a setup was designed and developed to reproduce controlled exposure conditions on cells. The device was then used to perform an in-vitro study on mice dermal fibroblast cells. The device included six 30-mm planar ultrasound emitters. The acoustic pressure modelling was used to determine a uniform region where cells could be exposed to ultrasound. The uniformity was confirmed using measurements by a needle hydrophone. The cell culture plate was placed in the cell ultrasound exposure device at a height where cells were exposed to uniform acoustic pressure. Three embodiments of the cell ultrasound exposure device working at 330 kHz, 500 kHz and 1 MHz were built. The results showed that more than 70% of the well-area had a measured acoustic pressure at a set value of ±25%. Finally, designs were proposed for skin cancer treatment. Ultrasound emitter geometries were designed and modelled to maximize the treatment coverage and deliver a uniform acoustic pressure to the skin. The suggested emitter can fully cover the desired region over the face that needs to be treated.
title: Importance of sources of variability, scales and experimental design: A case study about the effects of biochar and slurry application on soil properties in agricultural silty loam soils
Creators: name: Ludwig, Bernard
name: Song, Xiaona
name: Gunina, Anna
name: Greenberg, Isabel
name: Dippold, Michaela Anna
name: Piepho, Hans-Peter
Publisher: name: Universität Kassel
Year: 2021
Subjects: subject: aggregates
subject: biochar
subject: experimental design
subject: field scale
subject: generalization
subject: naturally-occurring variability
subject: random intercept model
subject: sampling design
subject: slurry
subject: 540
subject: 570
subject: Pflanzenkohle
subject: Experimentelle Versuchsforschung
subject: Variabilität
subject: Stichprobenplan
subject: Schlufflehm

description: Gefördert im Rahmen des Projekts DEAL
Monika Fludernik, Verso una narratologia ‘naturale’
Creators: name: Pennacchio, Filippo
Publisher: name: Università degli Studi di Milano
Year: 2013
Subjects: Monika Fludernik; Verso una narratologia ‘naturale’; narratologia; cognitivismo; esperienzialità

description: Si traduce qui, per la prima volta in lingua italiana, un testo di Monika Fludernik. Si tratta di un saggio, pubblicato nel 1996 sul «Journal of Literary Semantics», in cui la studiosa austriaca anticipa alcuni dei contenuti che pochi mesi più tardi andranno a costituire il primo capitolo della sua opera a oggi più nota, e cioè Towards a ‘Natural’ Narratology. Tra le sue pagine, che di quest’ultima riprendono il titolo, Fludernik si sofferma sulle basi della propria teoria narratologica, oggi assai diffusa a livello internazionale ma al contrario poco o punto penetrata in Italia. A partire dai concetti di esperienzialità, embodiedness e racconto naturale, viene illustrato un paradigma teorico – la narratologia ‘naturale’, appunto – per più versi lontano dalle proposte di molti narratologi «classici», anzitutto nella misura in cui pone al suo centro il lettore, il suo coinvolgimento cognitivo con i testi. Non solo: nel corso della trattazione, Fludernik sottolinea come tale paradigma possa essere esteso in senso diacronico, come cioè i suoi presupposti consentano d’integrare le trasformazioni dai testi subite nel corso del tempo. In altre parole, esso si presta ad accogliere al suo interno una vasta gamma di forme narrative, dallo storytelling orale alla scrittura storiografica, e dai romanzi modernisti a larga parte della fiction secondonovecentesca.
La traduzione del saggio è fatta precedere da un’introduzione in cui viene presentato, più in generale, il pensiero di Monika Fludernik, e insieme valutato il suo ruolo nell’ambito del dibattito teorico sviluppatosi in seno alla comunità scientifica a partire dai primi anni Duemila.
description: ENTHYMEMA, No 8 (2013)
Identifying, Measuring, and Valuing the Intergenerational Spillover Effects Associated with Screening for Maternal Postpartum Depression in Alberta, Canada
Creators: name: Premji, Shainur
Publisher: name: Cumming School of Medicine
Year: 2022
Subjects: subject: postpartum depression
subject: screening
subject: spillover effects
subject: child development
subject: longitudinal observational research designs
subject: Health Sciences--Mental Health
subject: Economics--Theory
subject: Health Sciences--Public Health
subject: Education--Early Childhood
subject: Health Sciences--Epidemiology

description: Introduction: One in eight childbearing women is affected by postpartum depression (PPD). Left untreated, PPD is associated with adverse consequences for both mothers, fathers, and their developing children. In Alberta, screening takes place during two-month public health well child clinic visits. Previous research on the Alberta screening pathway demonstrated effectiveness and cost-effectiveness of PPD screening relative to not screening for mothers over a two-year time horizon. The purpose of this work was to build on our previous research by identifying, measuring, and valuing the intergenerational (child) spillover effects associated with the Alberta PPD screening pathway. We explored spillover effects in two ways: first, by examining the association between maternal PPD screening status and child development outcomes at ages 3 and 5 years, and second, by examining the association between maternal PPD screening status and annual child healthcare utilization and associated costs over the first five years of age. Methods: Mothers and children enrolled in the All Our Families (AOF) prospective pregnancy cohort were linked to public health, inpatient, outpatient, and physician claims data over five years postpartum. Unadjusted and adjusted bivariate and multivariable logistic and marginal effects regression models were used to estimate the relationship between maternal PPD screening status and child outcomes. Multiple imputation methods were used to estimate missing child development data. Results: Study findings were challenging to fully interpret. Our a priori hypothesis was that outcomes for children of mothers screened high risk for PPD would be equivalent to that of children whose mothers screened low/moderate risk, thereby indicating mitigated risk for adverse child outcomes through early identification and treatment of maternal PPD. However, we were unable to arrive at definitive causal inferences or associations due to a high potential for residual confounding, the likely presence of both selection and misclassification bias, and a failure to triangulate our findings across studies. Conclusion: Given the rising trend in economic evaluation studies employing real world evidence, learnings from this investigation offer the broader health economics community several directions for future consideration when evaluating the intergenerational spillover effects associated with screening for maternal PPD using longitudinal observational research designs.
La teoria dell’embodiment e il processo di apprendimento e insegnamento di una lingua
Creators: name: Buccino, Giovanni
name: Mezzadri, Marco
Publisher: name: Università degli Studi di Milano
Year: 2013
Subjects: Embodiment; neuroscienze; glottodidattica; esperienza; apprendimento linguistico

description: Questo articolo si compone di tre parti principali: nella prima parte vengono riportati in modo sintetico i risultati empirici di studi che sostengono la teoria del linguaggio incarnato, termine con il quale viene tradotto in lingua italiana il termine inglese embodied. Nella seconda parte vengono descritti alcuni aspetti di recenti approcci proposti per l’insegnamento e l’apprendimento di una lingua per sottolineare come, soprattutto a partire dalla seconda metà del secolo scorso, questi approcci hanno tentato di implementare nella didattica delle lingue dati empirici provenienti dalle neuroscienze di base. Infine, nella terza parte vengono suggerite alcune implicazioni per l’insegnamento delle lingue che trovano il loro fondamento nella prospettiva del linguaggio incarnato.
description: ENTHYMEMA, No 8 (2013)
The spectroscopic parameters of sodium cyanide, NaCN (X 1A'), revisited
Creators: name: Müller, Holger S. P.
name: Halfen, D. T.
name: Ziurys, L. M.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The study of the rotational spectrum of NaCN (X $^1$A') has recently been extended in frequency and in quantum numbers. Difficulties have been encountered in fitting the transition frequencies within experimental uncertainties. Various trial fits traced the difficulties to the incomplete diagonalization of the Hamiltonian. Employing fewer spectroscopic parameters than before, the transition frequencies could be reproduced within experimental uncertainties on average. Predictions of $a$-type $R$-branch transitions with $K_a \le 7$ up to 570 GHz should be reliable to better than 1 MHz. In addition, modified spectroscopic parameters have been derived for the 13C isotopic species of NaCN.
description: 5 pages, no figure, J. Mol. Spectrosc., appeared; CDMS links updated
In-between Actors. Die Rolle der Deutschen Botschaft in Paris auf dem Kunstmarkt während der deutschen Besatzung 1940−1944
Creators: name: Weier, Anna-Jo
Publisher: name: Humboldt-Universität zu Berlin
Year: 2023
Subjects: subject: Kunstraub
subject: Auswärtige Kulturpolitik
subject: Kunstmarktforschung
subject: Nationalsozialismus
subject: 060 Allgemeine Organisationen und Museumswissenschaft

description: Der Handel mit Kunst und Kulturgütern unter der militärischen Besatzung Frankreichs durch das Deutsche Reich in den Jahren 1940–1944 war geprägt vom Verfolgungsdruck gegen politische Gegner:innen des NS-Regimes, Juden, Jüdinnen, Sinti:zze und Rom:nja und einem mit dieser Gewalt zusammenhängenden, dynamisierten Kunstmarktgeschehen. Die Deutsche Botschaft in Paris war eine der zahlreichen Akteur:innen, die in den gewaltvollen Entzug von Objekten involviert war. Die Kontexte und variierenden Rollen, die Botschaftsangehörige in diesen Verlagerungen von Kulturgut einnahmen, sind Gegenstand meines Dissertationsprojektes. Anhand von zwei Fallbeispielen gebe ich im vorliegenden Aufsatz Einblicke in den Handlungsrahmen der Deutschen Botschaft und die Reichhaltigkeit der Primärquellen, mit denen dieser Themenkomplex bearbeitet wird. Der Schwerpunkt liegt hier auf der direkten Unterstützung deutscher Käufer:innen auf dem Kunstmarkt. Indem zudem der methodische Ansatz vorgestellt wird, sollen zwei Dinge deutlich werden: dass zum einen Aktivitäten auf dem Kunstmarkt keine rein bilateralen Transaktionen zwischen Käufer:in und Verkäufer:in darstellen, sondern von einer Vielzahl eingebundener Akteur:innen abhängig sind. Zum anderen lässt sich das Agieren der Botschaft als die Summe des Handelns ihrer Angehörigen definieren. Denn die zentrale Herausforderung liegt in der Frage, wer oder was eigentlich mit ‚der‘ Botschaft gemeint ist und wie sich ‚ihr‘ Handeln greifbar machen lässt, um die Verwicklung in (gewaltvolle) Objektverlagerungen nachzuvollziehen. Der vorliegende Beitrag zeigt, wie nützlich dafür eine methodische Herangehensweise mittels der Netzwerk- und Täter:innenforschung ist.
Seeing Inside a Concussion: The Role of Microglia in Maintaining the Blood-Brain Barrier in Repetitive Mild Traumatic Brain Injury
Creators: name: Nguyen, Rita H
Publisher: name: Cumming School of Medicine
Year: 2022
Subjects: subject: traumatic brain injury
subject: neuroinflammation
subject: microglia
subject: astrocytes
subject: blood-brain barrier
subject: Biology--Neuroscience
subject: Health Sciences--Immunology

description: Concussion, or mild traumatic brain injury, is a common type of brain injury that can cause significant debilitating symptoms despite no evidence of brain damage on common diagnostic imaging modalities. Repetitive concussion has recently come into focus in the public eye and among scientists as there is recognition that repeated injury can lead to chronic brain damage and neurologic impairment. There are currently no treatments or therapies available for concussion. The cellular events occurring in the brain parenchyma following concussion, especially repetitive concussion, are not well known. Neuroinflammation is one of the pathophysiologic mechanisms that is felt to play an important role in secondary mechanisms of injury in traumatic brain injury. Microglia are the resident immune cells of the brain; we hypothesize that they play a crucial role in the pathophysiology of concussion. Therefore, we sought to develop a murine model of repetitive concussion in order to study the neuroimmune response. Using intravital microscopy, we observe microglia to become progressively activated with repetitive injury. Activated microglia phagocytose dysfunctional astrocytes following repetitive concussion. Additionally, microglia rapidly seal areas of blood-brain barrier disruption. This process is dependent on purinergic pathways and microglial scavenger receptors. We also performed single-cell analysis to further dissect whether there exist separate populations of microglia that perform distinct roles following repetitive brain injury. Our results demonstrate that microglia play a critical protective role following concussion, but in doing so, alter the brain milieu. This thesis provides new insight into the response of microglia and astrocytes following repetitive mild traumatic brain injury. Understanding the neuroinflammatory mechanisms that occur following concussion will ultimately guide successful translation of therapeutic treatments.
Orbital evolution under the action of fast interstellar gas flow with non-constant drag coefficient
Creators: name: Pastor, P.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The acceleration of a spherical dust particle caused by an interstellar gas flow depends on the drag coefficient which is, for the given particle and flow of interstellar gas, a specific function of the relative speed of the dust particle with respect to the interstellar gas. We investigate the motion of a dust particle in the case when the acceleration caused by the interstellar gas flow represent a small perturbation to the gravity of a central star. We present the secular time derivatives of the Keplerian orbital elements of the dust particle under the action of the acceleration from the interstellar gas flow for arbitrary orbit orientation. The semimajor axis of the dust particle is a decreasing function of time for an interstellar gas flow acceleration with constant drag coefficient and also for such an acceleration with the linearly variable drag coefficient. The decrease of the semimajor axis is slower for the interstellar gas flow acceleration with the variable drag coefficient. The minimal and maximal values of the decrease of the semimajor axis are determined. In the planar case, when the interstellar gas flow velocity lies in the orbital plane of the particle, the orbit always approaches the position with the maximal value of the transversal component of the interstellar gas flow velocity vector measured at perihelion. The properties of the orbital evolution derived from the secular time derivatives are consistent with numerical integrations of the equation of motion. If the interstellar gas flow speed is much larger than the speed of the dust particle, then the linear approximation of dependence of the drag coefficient on the relative speed of the dust particle with respect to the interstellar gas is usable for practically arbitrary (no close to zero) values of the molecular speed ratios (Mach numbers).
description: 12 pages, 6 figures, 2 equations added in v3
Electrophysiological Features of Emotion and Conflict Processing in Human Subgenual Cingulate
Creators: name: Zalasky, Nicole A
Publisher: name: Cumming School of Medicine
Year: 2022
Subjects: subject: Cognition
subject: Emotion
subject: Cingulate
subject: Stroop
subject: Salience
subject: Spike-field
subject: Valence
subject: Conflict
subject: Biological Sciences
subject: Health And Environmental Sciences

description: Background: The subgenual anterior cingulate cortex (sgACC) has been identified as a key brain area involved in various cognitive and emotional processes. While previous studies have implicated sgACC single neuron and population level activity in both emotional valuation processes and emotional conflict monitoring mechanisms, it is still unclear how this area functions in relation to multiple top-down processes.Methods: To clarify these functional roles of the sgACC, we measured both single neuron and local field potential oscillatory activity in 14 patients undergoing sgACC deep brain stimulation for treatment resistant depression while viewing emotional images varying in valence and congruence during an emotional Stroop task. We further analyzed spike-field interactions to understand how network dynamics influence local single neuron activity in this area.Results: Majority of single neurons responded to both valence and congruence. During peak single unit response, we also observed increased spectral power in low frequency oscillations, including theta-band synchronization (4-8Hz), as well as reduced spectral power in high beta oscillations (13-30Hz). Theta activity was modulated by current trial congruency, with greater increases in spectral power following non-congruent stimuli. Spike-field interactions revealed that local sgACC spiking activity was phase-locked most prominently to the high beta frequency component.Conclusions: These findings reveal that sgACC neuronal activity can reflect multiple implicit cognitive functions at the same time, indicative of multifunctionality amongst single neurons. Our data endorses the sgACC as a hub for both top-down and bottom-up control during implicit emotional processing through modulation of beta and theta network activity.
Vom Ding zum Konvolut. Sammlungsarchäologie und Provenienzforschung
Creators: name: Nadarzinski, Martin
Publisher: name: Humboldt-Universität zu Berlin
Year: 2023
Subjects: subject: Provenienzforschung
subject: Sammlung
subject: Sammlungsarchäologie
subject: Assemblage-Theorie
subject: 060 Allgemeine Organisationen und Museumswissenschaft

description: Provenienzforschung im Bereich des NS-verfolgungsbedingt entzogenen oder aus kolonialen Kontexten stammenden Kulturguts hat seit mehreren Jahren Konjunktur in deutschsprachigen Museen und den Fachdiskursen. Dabei werden Sammlungen häufig nur als Wegmarken aufgefasst oder in der Hintergrundrecherche behandelt. Methodisch wie theoretisch wird hierbei oft die Metapher der Objektbiographie verwendet, eine weiterführende theoretische Auseinandersetzung mit der Translokation von Kulturgütern findet meist nicht statt. Museumssammlungen weisen aber mehrere Besonderheiten auf, die die Translokation von Kulturgütern beeinflussen können. Daher schlägt dieser Beitrag eine Erweiterung der Untersuchungsperspektive auf Museumssammlungen vor. Diese Erweiterung wird theoretisch durch zwei Perspektiven gestützt: Die Assemblage-Theorie bietet eine Grundlage zum Verständnis und theoretischen Beschreiben einer Museumssammlung, die Sammlungsarchäologie stellt die methodische Erweiterung dar. Schlussendlich werden diese beiden Ansätze zusammengeführt. Der Beitrag basiert auf Forschungen des Autors im Rahmen seiner Promotion, die sich mit der ethnographischen Sammlung des Badischen Landesmuseums von 1875 bis heute auseinandersetzt.
Inference of Natural Selection from Interspersed Genomic Elements Based on Polymorphism and Divergence
Creators: name: Gronau, Ilan
name: Arbiza, Leonardo
name: Mohammed, Jaaved
name: Siepel, Adam
Publisher: name: arXiv
Year: 2011
Subjects: subject: Genomics (q-bio.GN)
subject: FOS: Biological sciences

description: Complete genome sequences contain valuable information about natural selection, but extracting this information for short, widely scattered noncoding elements remains a challenging problem. Here we introduce a new computational method for addressing this problem called Inference of Natural Selection from Interspersed Genomically coHerent elemenTs (INSIGHT). INSIGHT uses a generative probabilistic model to contrast patterns of polymorphism and divergence in the elements of interest with those in flanking neutral sites, pooling weak information from many short elements in a manner that accounts for variation among loci in mutation rates and genealogical backgrounds. The method is able to disentangle the contributions of weak negative, strong negative, and positive selection based on their distinct effects on patterns of polymorphism and divergence. Information about divergence is obtained from multiple outgroup genomes using a full phylogenetic model. The model is efficiently fitted to genome-wide data by decomposing the maximum likelihood estimation procedure into three straightforward stages. The key selection-related parameters are estimated by expectation maximization. Using simulations, we show that INSIGHT can accurately estimate several parameters of interest even in complex demographic scenarios. We apply our methods to noncoding RNAs, promoter regions, and transcription factor binding sites in the human genome, and find clear evidence of natural selection. We also present a detailed analysis of particular nucleotide positions within GATA2 binding sites and primary micro-RNA transcripts.
description: 21 page manuscript, 4 figure, 4 tables + 3 supp figures + 3 supp tables + supp methods. V4: additional results on human noncoding RNAs annotated by GENCODE + refinement of previous versions + additional supplementary material included to main document. V5: some minor modifications. V6: this is an electronic version of an article published in Mol Biol Evol, 2013
Empirical Tests of the Capital Asset Pricing Model (CAPM) Using Data From New York Stock Exchange Market
Creators: name: Abdulkarim, Habib
Publisher: name: Humanities Commons
Year: 2021
Subjects: Literature and economics

description: This study examines the validity of the Capital Assets Pricing Model (CAPM) using monthly and weekly data on 780 stocks from the New York Stock Exchange Market for period of March,1992 to May, 2012, under the traditional first-pass/second-pass methodology. Comparative analysis of results is made between equally-weighted and timevarying value weighted portfolios. The study also examines differences in results of the test of the CAPM between the static and the Rolling Ordinary Least Squared (OLS) techniques, when applied in estimating the betas for the purpose of testing the model. We find that results from tests of the CAPM using the first-pass/second-pass technique, are both sensitive to number of observations used as sample and also to the portfolio construction methodology adopted. It is also found that the static OLS methodology explains more about risk premium than the rolling OLS methodology. In consistency with the CAPM predictions, both the static and rolling OLS methodologies provide evidence that non-systematic risks command no premium. Also the Security Market Line (SML) estimation for both methodologies provide steeper slope, in contrast with previous studies. However, while the static OLS methodology provides evidence that expected return-beta relationship is linear, the rolling OLS provide some evidence of non-linearity.
Parenting Outside the Lines: How do bisexual parents experience their sexual identity as parents? A qualitative longitudinal study
Creators: name: Hingston, Saryn R
Publisher: name: Cumming School of Medicine
Year: 2022
Subjects: subject: Health Sciences--Public Health
subject: Sociology--Individual and Family Studies
subject: Gender Studies

description: The aim of this research is to increase understanding and knowledge of the experience of parenting while bisexual and how this experience may change over time. This is important due to evidence that bisexual people are more likely to become parents than homosexual people and experience greater general distress than their homosexual counterparts. Five participants engaged in two rounds of semi-structured interviews; initial interviews took place in 2015-2016 and follow up interviews in 2020-2021. Purposive sampling with recruitment through social media resulted in recruitment of two men and three women who all identified as bisexual and lived with their children. Through Interpretive Phenomenological Analysis, the interviews were analyzed and discussed in relation to existing theory on stigma and visibility. Three main themes were identified including visibility, values, and parenting, which highlighted participants’ experiences of stigma and their values of affirming parenting and building safe community.
Characterizing the role of primary cilia in astrocytes
Creators: name: Huynh, Vanessa P.K.
Publisher: name: Cumming School of Medicine
Year: 2021
Subjects: subject: Astrocyte
subject: primary cilia
subject: Biology--Neuroscience

description: Astrocytes are the most prevalent glial cells in the brain and play a central role in development, neuronal transmission, and disease pathogenesis in the central nervous system. The functions of astrocytes are enabled by their complex yet plastic morphology characterized by ramified arborizations and membrane protrusions that allow them to closely contact neuronal elements and modulate synaptic functions. Likewise, many genes required for astrocyte function are dynamic and respond to changes in environmental stimuli. However, the signalling mechanisms governing astrocyte morphology and gene expression have yet to be elucidated. Primary cilia, small hair-like signalling antenna that protrude from the soma, play a key role in signalling as their membrane are highly enriched with receptors. Sonic hedgehog is a signalling pathway that has been extensively studied in relation to primary cilia during development. Although Shh signalling influences astrocyte differentiation and function, little is known about the role of primary cilia in these cells. Using a conditional knockout mouse model, I investigated the consequences of impaired ciliary function in astrocytes. This thesis provides the evidence that Shh signalling likely occurs through the primary cilia in astrocytes, astrocytes with defective primary cilia have altered morphology and gene expression. Furthermore, mice with ciliary mutant astrocytes display differences in behaviour. The results from this work offer a foundation for furthering our understanding of primary cilia signalling in astrocyte biology.
Googling The Cancer Genome
Creators: name: Shneider, Carl
name: Ridder, Jeroen De
name: Kloosterman, Wigard
name: Nieboer, Marleen
name: Georgievska, Sonja
name: Kuzniar, Arnold
Publisher: name: Zenodo
Year: 2017
Subjects: Cancer
Structural Variants
Deep Learning
Whole-Genome Sequencing (WGS)

description: Poster presentation at the National eScience Symposium 2017, The Netherlands.
description: Associated Links:
https://www.esciencecenter.nl/project/googling-the-cancer-genome
https://blog.esciencecenter.nl/teaching-machines-to-recognize-cancer-420da40f547d
title: And then, there is light: meshes visible through MRI
Creators: name: Diez, Isabel
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Education and training
subject: Imaging sequences
subject: MR
subject: Soft tissues / Skin
subject: Gastrointestinal tract
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Reviewing the current classification of wall hernias and repair indications with preaponeurotic meshes Describing the RM protocol that we use in our Center for the valuation of the meshes Getting acquainted with the different sequences of MRI and...
Buchstäbliche B(r)uchstücke. NS-Provenienzforschung in modernen Universitätsbibliotheken
Creators: name: Sauerwein, Tessa
Publisher: name: Humboldt-Universität zu Berlin
Year: 2023
Subjects: subject: Provenienzforschung
subject: Universitätsbibliothek
subject: Entnazifizierung
subject: Landesgeschichte
subject: 060 Allgemeine Organisationen und Museumswissenschaft

description: Die Entnazifizierung nach dem Ende des Zweiten Weltkrieges betraf Personen, aber auch Bibliotheken und ihre Bestände. Buchstäbliche B(r)uchstücke dieses bisher kaum untersuchten Transformationsprozesses finden sich noch heute weltweit verstreut in ihren Regalen. Aber wie und warum kamen sie dorthin? Und wie geht man mit diesen brisanten und belasteten Hinterlassenschaften um, insbesondere wenn sie in modernen Wissensräumen von Universitäten entdeckt werden? Sollten derartige Relikte aus der NS-Zeit unbemerkt entsorgt werden, um Platz für aktuelle Forschungsliteratur zu schaffen? Dieser Beitrag versucht, Antworten und Anregungen zu liefern, indem er den Forschungsrahmen und erste Ergebnisse einer derzeit laufenden Dissertation am Institut für Fränkische Landesgeschichte der Universitäten Bamberg und Bayreuth vorstellt. Anhand von Besitzstempeln verfolgt sie die Wege von ehemaligen NSDAP-Parteibüchereien bis in heutige wissenschaftliche Bibliotheken.
Dynamically generating arbitrary spin-orbit couplings for neutral atoms
Creators: name: Xu, Z. F.
name: You, L.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: Spin-orbit coupling (SOC) can give rise to interesting physics, from spin Hall to topological insulators, normally in condensed matter systems. Recently, this topical area has extended into atomic quantum gases in searching for artificial/synthetic gauge potentials. The prospects of tunable interaction and quantum state control promote neutral atoms as nature's quantum emulators for SOC. Y.-J. Lin {\it et al.} recently demonstrated a special form of the SOC $k_xσ_y$: which they interpret as an equal superposition of Rashba and Dresselhaus couplings, in bose condensed atoms [Nature (London) \textbf{471}, 83 (2011)]. This work reports an idea capable of implementing arbitrary forms of SOC by switching between two pairs of Raman laser pulses like that used by Lin {\it et al.}. While one pair affects $k_xσ_y$ for some time, a second pair creates $k_yσ_y$ over other times with Raman pulses from different directions and a subsequent spin rotation into $\pm k_yσ_x$. With sufficient many pulses, the effective actions from different durations are small and accumulate in the same exponent despite that $k_xσ_y$ and $\pm k_yσ_x$ do not commute. Our scheme involves no added complication, and can be demonstrated within current experiments. It applies equally to bosonic or fermionic atoms.
description: 5 pages, 2 figures
title: Precision cancer therapies in lung cancer: Current status and role of the image
Creators: name: Araujo, Pedro
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Drugs / Reactions
subject: Treatment effects
subject: CT-High Resolution
subject: CT
subject: Thorax
subject: Oncology
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The objectives of this work are: Brief overview of new oncology drugs in lung cancer: targeted drugs and immunotherapy Key points of response patterns according iRECIST Examples and discussion of events related to new oncologic treatments, including...
To Be Involved or Not To Be Involved: The Academic Impact of Extracurricular Activities in Freshmen during the Transition to High School
Creators: name: Schnellenberger-Gerhart, Karen
Publisher: name: Unknown
Year: 2023
Subjects: subject: Extracurricular activities
subject: Transition to high school
subject: Freshmen
subject: High school academics
subject: Student activities
subject: Extracurricular activities
subject: Transition to high school
subject: Freshmen
subject: High school academics

description: The transition to high school can be challenging for students. New teachers, new classes, and a new building can be daunting. Time commitments and coursework can become more intense. While many students succeed during this transition, some students falter. This research study examines the relationship between involvement in school-sponsored extracurricular activities and academics in high school freshman experiencing the transition to high school in a large suburban Midwest school. Through the use of an informational data form that included a count of activity involvement during the ninth-grade year, academic status, including the academic data of number of failed semester courses and grade point average, and reasoning for not becoming involved, this study concludes that there is significance between involvement in school-sponsored extracurricular activities during freshman year of high school and academics. Less semester courses are failed and grade point averages are higher in those that participate in school-sponsored extracurricular activities during the freshman year of high school.
Mappings of open quantum systems onto chain representations and Markovian embeddings
Creators: name: Woods, M. P.
name: Groux, R.
name: Chin, A. W.
name: Huelga, S. F.
name: Plenio, M. B.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We derive a sequence of measures whose corresponding Jacobi matrices have special properties and a general mapping of an open quantum system onto 1D semi infinite chains with only nearest neighbour interactions. Then we proceed to use the sequence of measures and the properties of the Jacobi matrices to derive an expression for the spectral density describing the open quantum system when an increasing number of degrees of freedom in the environment have been embedded into the system. Finally, we derive convergence theorems for these residual spectral densities.
description: 44 pages, 1 figure. V2, small changes
International Students Challenges During the Pandemic in Higher Education
Creators: name: Mushfiq, Merab
Publisher: name: York University, Toronto, ON
Year: 2023

description: This study was conducted at a post-secondary institution in Southwestern Ontario. International students face various challenges such as language barriers, loneliness, academic challenges, and culture shock. However, these challenges have heightened during the pandemic because of lockdowns, restrictions, online classes, and various programming were either paused or cancelled. During qualitative interviews, international students expressed various academic learning challenges due to blended and/or online learning which was impacting their mental health well-being. Some recommendations are suggested to incorporate intercultural awareness in online and blended teaching. Additionally, it is important to incorporate teaching pedagogies where students can actively participate and own learning.
Freezers, Dry Ice and Phase-Change Materials for Cold Chain Equipment in Ultra Low Temperature Logistics
Creators: name: Sparavigna, Amelia Carolina
Publisher: name: Zenodo
Year: 2021
Subjects: Freezers
Dry Ice
PCM
PCC
Composite Materials
Phase Change Composites
Thermal Management
Latent Heat Storage
Ultra Low Temperature Logistics
Cold Chain
Materials Science
, Logistics

description: Freezers and dry ice are used for the cold supply-chain. In storage devices, besides dry ice, the phase change materials (PCMs) are involved too. A PCM is a substance absorbing and releasing energy at phase transition. The substance is therefore useful for heating and cooling applications. Here we review some facts about the use of freezers, dry-ice and PCMs for equipment in the Ultra Low Temperature Logistics.
Optimizing network-on-chips for FPGAs
Creators: name: Kwa, Jimmy Williamchingyuan
Publisher: name: University of British Columbia
Year: 2013

description: As larger System-on-Chip (SoC) designs are attempted on Field Programmable Gate Arrays (FPGAs), the need for a low cost and high performance Network-on-Chip (NoC) grows. Virtual Channel (VC) routers provide desirable traits for an NoC such as higher throughput and deadlock prevention but at significant resource cost when implemented on an FPGA. This thesis presents an FPGA specific optimization to reduce resource utilization. We propose sharing Block RAMs between multiple router ports to store the high logic resource consuming VC buffers and present the Block RAM Split (BRS) router architecture that implements the proposed optimization. We evaluate the performance of the modifications using synthetic traffic patterns on mesh and torus networks and synthesize the NoCs to determine overall resource usage and maximum clock frequency. We find that the additional logic to support sharing Block RAMs has little impact on Adaptive Logic Module (ALM) usage in designs that currently use Block RAMs while at the same time decreasing Block RAM usage by as much as 40%. In comparison to CONNECT, a router design that does not use Block RAMs, a 71% reduction in ALM usage is shown to be possible. This resource reduction comes at the cost of a 15% reduction in the saturation throughput for uniform random traffic and a 50% decrease in the worst case neighbour traffic pattern on a mesh network. The throughput penalty from the neighbour traffic pattern can be reduced to 3% if a torus network is used. In all cases, there is little change in network latency at low load. BRS is capable of running at 161.71 MHz which is a decrease of only 4% from the base VC router design. Determining the optimum NoC topology is a challenging task. This thesis also proposes initial work towards the creation of an analytical model to assist with finding the best topology to use in an FPGA NoC.