cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
E5.3 Intermediate prototype for data aggregation for self-optimization processes on network operations
Creators: name: i2CAT
Publisher: name: Zenodo
Year: 2024

description: Data aggregation is key when analyzing the trends and behaviors of the network. However, due to the massive amount of data, it is necessary to perform an statistical analysis rather than a specific one. Statistical aggregation is essential in data analysis for summarizing large datasets into manageable decisions and identifying patterns and trends. By condensing data at different levels of granularity, such as time intervals orgeographic regions, analysts can uncover valuable insights that drive decision-making. Aggregating data also enables comparisons between groups or categories, helping to compare performance and identify outliers. Moreover, aggregation helps reduce noise and variability in the data, making it easier to discern underlying signals. Visualizations of aggregated data, such as charts and graphs, are powerful tools for communicatingfindings to stakeholders and decision-makers, facilitating understanding and informed decision-making processes. The statistical technique that we used in 6G-ENABLERS for data aggregation for self-optimization processes on network operations is called statistical aggregation based on Cumulative Distribution Function (CFD).
Additional file 2 of HDAC5 inhibition attenuates ventricular remodeling and cardiac dysfunction
Creators: name: Zhu, Chenxi
name: Piao, Zhehao
name: Jin, Li
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Supplementary Material 2
sj-docx-1-eea-10.1177_01445987231196917 - Supplemental material for Prospective geothermal well and heat catchment locations in Nigeria: Remote sensing interpretations and field validation
Creators: name: Akpan, GE
name: Emetere, ME
name: Afolalu, SA
name: Jen, TC
Publisher: name: SAGE Journals
Year: 2023
Subjects: Materials Engineering not elsewhere classified

description: Supplemental material, sj-docx-1-eea-10.1177_01445987231196917 for Prospective geothermal well and heat catchment locations in Nigeria: Remote sensing interpretations and field validation by GE Akpan, ME Emetere, SA Afolalu and TC Jen in Energy Exploration & Exploitation
Attachment security in children with disability or developmental delay: Systematic review of quality and interventions
Creators: name: Alexander, Stacey
name: Frederico, Margarita
name: Long, Maureen
name: Vicendese, Don
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 39
subject: Education
classificationCode: 3904
subject: Specialist studies in education
classificationCode: 4201
subject: Allied health and rehabilitation science
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences

description: Secure attachment has broad and long-lasting benefits for the development and wellbeing of a child. Conversely, disorganized attachment is associated with social, emotional, and behavioral problems in children, and later psychopathology. Children with a developmental delay or disability (DD) may be at greater risk of insecure or disorganized attachment than children without DD. This systematic review aims to (1) synthesize the available evidence worldwide regarding attachment and children with DD and (2) to examine the effectiveness of interventions employed to prevent or address attachment insecurity for this population. Peer reviewed articles with four-fold attachment classification data or attachment interventions for children with DD were included in the review. Seventeen databases were searched for studies published in English from January 1980 to January 2019. The systematic review protocol was registered a priori with PROSPERO (CRD42018117574). Twenty-three articles met the inclusion criteria, nine containing strange situation procedure (SSP) data and 14 relating to interventions. Meta-analysis was conducted with data from six of the SSP articles (n = 215). The remaining articles were reviewed narratively. Results indicate that children with DD are significantly less likely to develop a secure attachment and significantly more likely to develop a disorganized attachment than children without DD. Emerging research indicates promise that early intervention may be effective in improving attachment security.
sj-pdf-1-asq-10.1177_00018392231203008 – Supplemental material for Countervailing Claims: Pro-Diversity Responses to Stigma by Association Following the Unite the Right Rally
Creators: name: Hurst, Reuben
Publisher: name: SAGE Journals
Year: 2023
Subjects: Organisation and Management Theory

description: Supplemental material, sj-pdf-1-asq-10.1177_00018392231203008 for Countervailing Claims: Pro-Diversity Responses to Stigma by Association Following the Unite the Right Rally by Reuben Hurst in Administrative Science Quarterly
Prediction of heat and fluid flow in a heat exchanger tube mounted with V-cone bundles
Creators: name: P. PROMTHAISONG
name: M. KUMAR
name: V. CHUWATTANAKUL
name: A. SAYSROY
name: S. EIAMSA-ARD
Publisher: name: Thai Society of Mechanical Engineers (TSME)
Year: 2018
Subjects: Heat exchanger
heat transfer enhancement
thermal performance
V-cone turbulator

description: Journal of Research and Applications in Mechanical Engineering (JRAME), 6, 1, 13-20
Additional file 1 of Longitudinal Covid-19 effects on child mental health: vulnerability and age dependent trajectories
Creators: name: Larsen, Linda
name: Schauber, Stefan Kilian
name: Holt, Tonje
name: Helland, Maren Sand
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health
subject: Computational Biology

description: Supplementary Material 1
Fundamentals of Conciliation in Cases of Trust-Deficit, when Everyone is just Mendacious
Creators: name: Mrwebi, Mandisi
Publisher: name: Zenodo
Year: 2024
Subjects: subject: Constitutional law
subject: Human rights law
subject: Law
subject: FOS: Law
subject: International Law/ethics
subject: International Law/education
subject: International Law/history
subject: African Union/history
subject: African People/education
subject: Political sciences
subject: Political policies
subject: Political philosophy
subject: Political violence
subject: Political economy
subject: Political Activism/trends
subject: Mediation Analysis

description: ABSTRACT

Reconstruction of trust is a basic existential necessity. Petty, as it may sound- but today all people want just to trust and be trusted. Colonial conquest completely obliterated ability to trust and be trusted. As a result the fast paced globalisation project can easily be reduced into; “one big animal farm- where all people are equal, but some people more equal than others” 

Trust is the missing cornerstone for resolving all our historic injustices. If only people could fostering a society capable of truth, peace and selfless development of the planet. The planet rewards all those who diligently serve it. In South Africa—and globally—centuries of colonization have left a legacy of distrust that undermines efforts at reconciliation and growth. Trust reconstruction requires moving beyond traditional methods of conflict resolution that have consistently failed to address the root causes of inequality and discord. This article examines the enduring influence of colonialism in South Africa, focusing on its systemic role in perpetuating inequality, mistrust, and conflict. It critiques the judicial system and legal fraternity for enabling post-colonial conflicts and challenges politicians to confront their reliance on colonial strategies. Highlighting the shift from overt colonialism to covert systems of control post-World War II, the article frames ongoing socio-economic crises and mistrust as deliberate colonial legacies.

Analyzing South Africa’s historical eras—spanning Dutch, British, Boer, apartheid, and democratic periods—the article explores how colonialism systematically dismantled Indigenous values like Ubuntu, replacing them with exploitative systems that foster division. It critiques policies like Black Economic Empowerment, arguing for more inclusive legislation that promotes sustainable generational wealth and social mobility.

Employing historical analysis, systemic critique, and legal reasoning, the study exposes the failure of current legal and policy frameworks to address conflicts rooted in colonial designs. It advocates for a paradigm shift where colonizers and the colonized engage in truth-based dialogue, relinquishing both power and authority to build a trust-based society. Finally, it calls for alternative dispute resolution mechanisms prioritizing trust, fairness, and historical justice to achieve sustainable and equitable development.
Additional file 2 of Longitudinal Covid-19 effects on child mental health: vulnerability and age dependent trajectories
Creators: name: Larsen, Linda
name: Schauber, Stefan Kilian
name: Holt, Tonje
name: Helland, Maren Sand
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health
subject: Computational Biology

description: Supplementary Material 2
sj-docx-1-mrx-10.1177_01979183231205561 - Supplemental material for How Much Do “Local Policies” Matter for Refugee Integration? An Analytical Model and Evidence from a Highly Decentralized Country
Creators: name: Tjaden, Jasper
name: Spörlein, Christoph
Publisher: name: SAGE Journals
Year: 2023
Subjects: International Relations

description: Supplemental material, sj-docx-1-mrx-10.1177_01979183231205561 for How Much Do “Local Policies” Matter for Refugee Integration? An Analytical Model and Evidence from a Highly Decentralized Country by Jasper Tjaden and Christoph Spörlein in International Migration Review
sj-docx-1-asj-10.1177_00016993231204215 - Supplemental material for Political icon and role model: Dimensions of the perceived ‘Greta effect’ among climate activists as aspects of contemporary social movement leadership
Creators: name: Wahlström, Mattias
name: Uba, Katrin
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: Sociology
subject: FOS: Sociology

description: Supplemental material, sj-docx-1-asj-10.1177_00016993231204215 for Political icon and role model: Dimensions of the perceived ‘Greta effect’ among climate activists as aspects of contemporary social movement leadership by Mattias Wahlström and Katrin Uba in Acta Sociologica
Additional file 3 of Longitudinal Covid-19 effects on child mental health: vulnerability and age dependent trajectories
Creators: name: Larsen, Linda
name: Schauber, Stefan Kilian
name: Holt, Tonje
name: Helland, Maren Sand
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health
subject: Computational Biology

description: Supplementary Material 3
Gene expression profiles in earthworms exposed to ZnO and ZnO:Mn nanomaterials
Creators: name: van Lingen, Henk J.
Publisher: name: Zenodo
Year: 2024

description: Metal containing nanomaterials applied for various purposes such as cosmetic products may be released into the environment during their use. These nanomaterials, which are studied within the EU project DIAGONAL, can be taken up by various organisms, then bioaccumulate and potentially exert toxic effects. Uptake of metal nanomaterials in organisms such as earthworms was previously demonstrated to increase through dissolution in water in the soil ecosystem. However, modes of action, gene regulation and metabolism in earthworms exposed to metal oxide nanomaterials and metal ions are largely unexplored. The aim of our study is to quantify gene expression in earthworms (Eisenia fetida) in response to ZnO:Mn nanomaterial and MnCl2 exposure using bulk RNA-seq analysis.

In a first experiment, earthworms were either exposed to clean reference soil or to soil contaminated with the ZnO nanomaterial. Earthworms were harvested after 2, 3 and 7 days of exposure. In addition, a second experiment was performed in which earthworms were exposed to the ZnO:Mn nanomaterial and to a MnCl2 positive control treatment and their negative control treatments. Whole earthworms from all these experiments were ground after which the ground tissue after which a transcriptomics analysis was performed. 

Depending on the experiment, extracted and sequenced RNA was assembled and annotated de novo or using a reference database, which resulted in read count number per gene and sampled earthworms. Reads counts were normalized and analyzed for differential gene expression along with potential time-dependent effects in the third experiment. Functional enrichment of genes found differentially expressed in the obtained RNA-seq data identifies how these genes are involved in regulating the response to ZnO and ZnO:Mn nanomaterials and MnCl2 in earthworms.
sj-docx-5-tam-10.1177_17588359231205853 – Supplemental material for PD-L1 expression-related PI3K pathway correlates with immunotherapy efficacy in gastric cancer
Creators: name: Liu, Langbiao
name: Niu, Lei
name: Zheng, Xue
name: Xiao, Fei
name: Sun, Huaibo
name: Deng, Wei
name: Cai, Jun
Publisher: name: SAGE Journals
Year: 2023
Subjects: Oncology and Carcinogenesis not elsewhere classified
Aged Health Care
Pharmacology and Pharmaceutical Sciences not elsewhere classified
Respiratory Diseases

description: Supplemental material, sj-docx-5-tam-10.1177_17588359231205853 for PD-L1 expression-related PI3K pathway correlates with immunotherapy efficacy in gastric cancer by Langbiao Liu, Lei Niu, Xue Zheng, Fei Xiao, Huaibo Sun, Wei Deng and Jun Cai in Therapeutic Advances in Medical Oncology
sj-docx-2-hpp-10.1177_15248399231206088 – Supplemental material for The Measurement Approaches to Partnership Success (MAPS) Questionnaire and Facilitation Guide: A Validated Measure of CBPR Partnership Success
Creators: name: Brush, Barbara L.
name: Israel, Barbara
name: Coombe, Chris M.
name: Lee, Shoou-Yih D.
name: Jensen, Megan
name: Wilson-Powers, Eliza
name: Gabrysiak, Adena
name: Chandanabhumma, P. Paul
name: Baker, Elizabeth
name: Jones, Marita
name: Lachance, Laurie
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: Health and Community Services
subject: Public Health and Health Services not elsewhere classified
subject: Sociology
subject: FOS: Sociology

description: Supplemental material, sj-docx-2-hpp-10.1177_15248399231206088 for The Measurement Approaches to Partnership Success (MAPS) Questionnaire and Facilitation Guide: A Validated Measure of CBPR Partnership Success by Barbara L. Brush, Barbara Israel, Chris M. Coombe, Shoou-Yih D. Lee, Megan Jensen, Eliza Wilson-Powers, Adena Gabrysiak, P. Paul Chandanabhumma, Elizabeth Baker, Marita Jones and Laurie Lachance in Health Promotion Practice
Supplemental Material - The Mediating Role of Sense of Control in the Associations Between Remote Contacts and Loneliness Among Older Adults
Creators: name: Yoon, Dokyung
name: Gallo, Haley
name: Gassoumis, Zachary D.
name: Joo, Susanna
Publisher: name: SAGE Journals
Year: 2023
Subjects: Geriatrics and Gerontology
Psychology not elsewhere classified

description: Supplemental Material for The Mediating Role of Sense of Control in the Associations Between Remote Contacts and Loneliness Among Older Adults by Dokyung Yoon, Haley Gallo, Zach Gassoumis, and Susanna Joo in Research on Aging
Additional file 1 of Deep learning based on susceptibility-weighted MR sequence for detecting cerebral microbleeds and classifying cerebral small vessel disease
Creators: name: Wu, Ruizhen
name: Liu, Huaqing
name: Li, Hao
name: Chen, Lifen
name: Wei, Lei
name: Huang, Xuehong
name: Liu, Xu
name: Men, Xuejiao
name: Li, Xidan
name: Han, Lanqing
name: Lu, Zhengqi
name: Qin, Bing
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1: Table S1. Detailed SWS acquisition. Table S2. Results for each run of ten-fold cross-validation of the model for CSVD classification. Table S3. Results of four neurologists’ performance in classifying CSVD on the external test set. Figure S1. Confusion matrices for neurologists’ performance in classifying CSVD on the external test set. A neurologist W.L, B neurologist T.T.L, C neurologist X.X.H, D neurologist X.L.
sj-docx-1-nnr-10.1177_15459683231206743 – Supplemental material for Combined Reactive and Volitional Step Training Improves Balance Recovery and Stepping Reaction Time in People With Parkinson’s Disease: A Randomised Controlled Trial
Creators: name: Pelicioni, Paulo H. S.
name: Lord, Stephen R.
name: Menant, Jasmine C.
name: Chaplin, Carly
name: Canning, Collen
name: Brodie, Matthew A.
name: Sturnieks, Daina L.
name: Okubo, Yoshiro
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: Geriatrics and Gerontology
subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Neuroscience

description: Supplemental material, sj-docx-1-nnr-10.1177_15459683231206743 for Combined Reactive and Volitional Step Training Improves Balance Recovery and Stepping Reaction Time in People With Parkinson’s Disease: A Randomised Controlled Trial by Paulo H. S. Pelicioni, Stephen R. Lord, Jasmine C. Menant, Carly Chaplin, Collen Canning, Matthew A. Brodie, Daina L. Sturnieks and Yoshiro Okubo in Neurorehabilitation and Neural Repair
Short-term gene expression dynamics in earthworms exposed to ZnO nanomaterial
Creators: name: van Lingen, Henk J.
Publisher: name: Zenodo
Year: 2024

description: Metal containing nanomaterials applied for various purposes such as cosmetic products may be released into the environment during their use. These nanomaterials, which are studied within the EU project DIAGONAL, can be taken up by various organisms, then bioaccumulate and potentially exert toxic effects. Uptake of metal nanomaterials in environmental organisms such as earthworms was previously demonstrated to depend on the properties of the soil (e.g. Lahive et al., 2023). However, modes of action, gene regulation and metabolism in earthworms exposed to metal nanomaterials are largely unexplored. The aim of our study is to quantify gene expression in earthworms (Eisenia fetida and Eisenia andrei) in response to ZnO nanomaterial exposure using bulk RNA-seq analysis.

Earthworms were either exposed to clean reference soil or to soil contaminated with the ZnO nanomaterial. Earthworms were harvested after 2, 3, 4 and 7 days of exposure to control or ZnO contaminated soil. Whole earthworms were ground in liquid nitrogen after which the ground tissue was divided into two equal amounts enabling both transcriptomics and metabolomics analysis. RNA was extracted using a TRIzol kit after which libraries were prepared and then sequenced using an Illumina Novaseq platform. Assembled reads were mapped to genes using the reference genomes with accession numbers GCA_003999395.1 and GWHACBE00000000 for E. fetida and E. andrei, respectively. Reads counts were normalized using the relative log expression method. Thereafter differential gene expression analysis was performing to identify any effect induced by the ZnO nanomaterial along with potential time-dependent effects. Functional enrichment of genes found differentially expressed in the obtained RNA-seq data will identify how these genes are involved in regulating the response to ZnO nanomaterials in earthworms with respect to time.

The present study is unique in assessing the gene expression responses in earthworms over days 0, 2, 3, 4 and 7 from the start of the exposure to ZnO. In addition, elucidating this response aims to cover potential mechanisms towards exposure to ZnO. Finally, the response assesses to what extent applications of ZnO nanomaterials such as cosmetic products and sunscreens can be considered non-toxic for environmental organisms in the soil.
sj-docx-1-mcr-10.1177_10775587231204105 – Supplemental material for Factors Associated With Intent to Leave the Profession for the Allied Health Workforce: A Rapid Review
Creators: name: Roth, Leonard
name: Le Saux, Clara
name: Gilles, Ingrid
name: Peytremann-Bridevaux, Isabelle
Publisher: name: SAGE Journals
Year: 2023
Subjects: Public Health and Health Services not elsewhere classified
Sociological Methodology and Research Methods

description: Supplemental material, sj-docx-1-mcr-10.1177_10775587231204105 for Factors Associated With Intent to Leave the Profession for the Allied Health Workforce: A Rapid Review by Leonard Roth, Clara Le Saux, Ingrid Gilles and Isabelle Peytremann-Bridevaux in Medical Care Research and Review
sj-docx-3-psp-10.1177_01461672231202756 – Supplemental material for Why Do People Think Individuals in Poverty Are Less Vulnerable to Harm?: Testing the Role of Intuitions About Adaptation
Creators: name: Cheek, Nathan N.
name: Murray, Jackson
Publisher: name: SAGE Journals
Year: 2023
Subjects: Psychology not elsewhere classified

description: Supplemental material, sj-docx-3-psp-10.1177_01461672231202756 for Why Do People Think Individuals in Poverty Are Less Vulnerable to Harm?: Testing the Role of Intuitions About Adaptation by Nathan N. Cheek and Jackson Murray in Personality and Social Psychology Bulletin
title: Mitteilungen aus dem pharm.-chem. Laboratorium der technischen Hochschule in Braunschweig Jahrgang 1. 1899
Creators: name: Pharmazeutisch-Chemisches Laboratorium Braunschweig
name: Pharmaceutisches Institut Braunschweig
Publisher: name: Laboratorium
Year: 1899
Subjects: subject: 615

description: Mitteilungen aus dem Pharm.-Chem. Laboratorium der Technischen Hochschule in Braunschweig, vol. 1
Additional file 1 of Identifying potential therapeutic targets of mulberry leaf extract for the treatment of type 2 diabetes: a TMT-based quantitative proteomic analysis
Creators: name: Shi, Lu
name: Wang, Jingkang
name: He, Changhao
name: Huang, Yan
name: Fu, Wanxin
name: Zhang, Huilin
name: An, Yongcheng
name: Wang, Menglu
name: Shan, Ziyi
name: Li, Huimin
name: Lv, Yinglan
name: Wang, Chen
name: Cheng, Long
name: Dai, Hongyu
name: Duan, Yuhui
name: Zhao, Hongbin
name: Zhao, Baosheng
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified

description: Additional file 1.
Development of pseudotyped VSV-SARS-CoV-2 spike variants for the assessment of neutralizing antibodies
Creators: name: Cimen, Atike Nur
name: Torabfam, Gizem Celebi
name: Tok, Yesim Tuyji
name: Yucebag, Ebru
name: Arslan, Nese
name: Saribal, Devrim
name: Esken, Gulen
name: Dogan, Ozlem
name: Kuskucu, Mert Ahmet
name: Mete, Bilgul
name: Aygun, Gokhan
name: Tabak, Fehmi
name: Can, Fusun
name: Ergonul, Onder
name: Midilli, Kenan
name: Kutlu, Ozlem
name: Cetinel, Sibel
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Aim: Serological studies with pseudotyped viruses offer a safer alternative to live SARS-CoV-2 in evaluating neutralizing antibodies, enabling research in standard labs. Methods: The SARS-CoV-2 Spike pseudotyped vesicular stomatitis virus (VSV) pseudoviruses were generated using Spike of Wuhan strain and two variants (B.1.1.7, B.1.351) and utilized to evaluate the serum neutralizing activity of human plasma samples of vaccinated (n = 13) and healthy people (n = 2) compared with a plaque assay with authentic virus. Results: Neutralizing titer of convalescent plasma resulted with a good correlation (R2 = 0.7). Conclusion: We evaluated a safe and reliable pseudotyped virus system that effectively mimics authentic virus and correlates well with traditional assays. The developed system allows easier testing of variants and has the potential to improve vaccine development. Pseudotyped VSV-SARS-CoV-2 Spike can successfully measure neutralizing plasma activity of vaccinated individuals compared with plaque assays with authentic virus. The method of pseudovirus reported in the study can distinguish the neutralizing abilities of convalescent plasma against Spike variants such as Alpha (B.1.1.7), Beta (B.1.351) and Wuhan types. VSV-based pseudotyped virus system demonstrates greater sensitivity, specificity and correlation with plaque assay, crucial for assessing vaccine responses. BNT162b2-vaccinated individuals have exhibited higher neutralizing activity against authentic virus and pseudovirus than CoronaVac-vaccinated.
title: Surgical myocardial revascularization for three-vessel coronary artery disease: the importance of the surgical technique to the clinical outcome
title: Chirurgische Myokardrevaskularisation bei koronarer Dreigefäßerkrankung: Die Bedeutung der Operationstechnik für das klinische Ergebnis
titleType: AlternativeTitle
Creators: name: Vasiloi, Ion
Publisher: name: Philipps-Universität Marburg
Year: 2023
Subjects: CAD
KHK3
BIMA
clinical results,
Operationstechnik,
Chirurgische Technik
outcome
comparison
Coronary artery disease
Medical sciences Medicine
Medizin
Ergebnis
Koronare Herzkrankheit
3v-CAD
3-GE-KHK
T-Graft
Vergleich
three-vessel coronary artery disease
surgical technique
Koronare Dreigefäßerkrankung
Chirurgische Revaskularisation

description: Objective: 
The effect of two different coronary surgical revascularization techniques featuring skeletonized double mammary artery (BIMA) as T-graft, on the postoperative evolution of functional mitral valve regurgitation (MVR) is studied.

Methods: 
Early postoperative and mid-term outcome of complete BIMA revascularization (BIMA T-Graft) versus left-sided BIMA with right-sided aorto-coronary bypass (T-Graft + RACB) is analyzed by multivariable logistic regression, Cox-regression and Kaplan-Meier analysis in a series of 204 consecutive patients treated for triple-vessel coronary disease (3v-CAD).

Results: 
The T-Graft + RACB technique (n=104) enables higher number of total (4.02±0.87 vs. 3.71±0.69, p=0.015) and right-sided (1.21±0.43 vs. 1.02±0.32, p=0.001) coronary anastomoses and improves total bypass flow (125.88±92.41 vs. 82.50±49.26ml, p<0.0001), bypass flow/anastomosis (31.83±23.9 vs.22.77±14.23, p=0.001) and completeness of revascularization (84% vs.69%, p=0.014) compared to BIMA T-Graft strategy (n=100), respectively. 
The BIMA T-Graft strategy (HR=4.2, p=0.01) and preoperative presence of RCA occlusion (HR=3.006, p=0.023) are relevant risk factors of MVR-progression, while T-Graft + RACB technique protects against MVR-progression (X2= 14.04, p <0.0001) independent of the preoperative anatomic complexity (Syntax-score I: HR=16.2, p=0.156), of comorbidities (Syntax-score II: HR=1.901, p=0.751; Euroscore-II: HR=0.00, p=0.680), and without enhancing MACCE at 30-days (0.02% vs.0.08%, p=0.055), early mortality (0.96% vs.2%, p=0.617) and mortality at 5-years (5.8% vs.4%, p=0.748) when compared to BIMA T-Graft, respectively.

Conclusions: 
MVR worsened more after revascularization with BIMA T-Graft technique. When treating 3v-CAD, surgical replication of anatomical traits by providing two-inflow coronary revascularization, such as accomplished with the T-Graft + RACB technique, leads to improved completeness of revascularization and attenuates the postoperative progression of MVR independently of Syntax-scores and without increasing the risk for MACCE.
title: Mitteilungen aus dem pharm.-chem. Laboratorium der technischen Hochschule in Braunschweig Jahrgang 7. 1905
Creators: name: Pharmazeutisch-Chemisches Laboratorium Braunschweig
name: Pharmaceutisches Institut Braunschweig
Publisher: name: Laboratorium
Year: 1905
Subjects: subject: 615

description: Mitteilungen aus dem Pharm.-Chem. Laboratorium der Technischen Hochschule in Braunschweig, vol. 7
Generalized Geologic Map for Land-Use Planning: Pulaski County, Kentucky
Creators: name: Adams, T. Jeffrey
name: Davidson, Bart
name: Carey, Daniel I.
Publisher: name: Kentucky Geological Survey, University of Kentucky
Year: 2004

description: Abstract:
This map is not intended to be used for selecting individual sites. Its purpose is to inform land-use planners, government officials, and the public in a general way about geologic bedrock conditions that affect the selection of sites for various purposes. The properties of thick soils may supercede those of the underlying bedrock and should be considered on a site-to-site basis. At any site, it is important to understand the characteristics of both the soils and the underlying rock.
title: Systematische Analyse der Fitness-Effekte von TP53-Mutationen in Tumorzellen unter Nährstoffmangel und Aktivierung von p73
title: Systematic analysis of the fitness effects of TP53 mutations in tumor cells under nutrient deprivation and activation of p73
titleType: AlternativeTitle
Creators: name: Borowek, Anna
Publisher: name: Philipps-Universität Marburg
Year: 2023
Subjects: homology directed repair
GOF
TP53
CRISPR/Cas9
Nährstoffentzug
nutrient deprivation
p73
TP53-Mutationen
Medical sciences Medicine
Medizin

description: TP53 ist das am häufigsten mutierte Gen in menschlichen Tumoren. Mutationen des Tumorsuppressors p53 finden sich in fast allen Tumorentitäten, durchschnittlich in 50 % aller Patienten. Der Großteil der Mutationen sind einzelne Missense Mutationen, welche in der DNA-Bindungsdomäne liegen und zur Ausbildung eines mutierten Proteins ganzer Länge führen. Neben einem Funktionsverlust (LOF) oder der Behinderung des verbleibenden Wildtyp-Allels, bekannt als dominant-negativer Effekt (DN), kann eine Mutation auch zu einem gain of function (GOF) führen, sodass die Tumorzellen schneller proliferieren, metastasieren oder resistent gegenüber Zytostatika werden. Mechanistisch äußert sich GOF z.B. in metabolischen Veränderungen, auch unter Nährstoffmangel, oder der Inhibition anderer Tumorsuppressoren wie p73. Bisher wurde dies nur für einzelne wenige p53-Mutationen gezeigt, jedoch liegen in Patienten viele verschiedene vor, die sich in ihren Auswirkungen unterscheiden. Ziel dieser Arbeit war es, diverse Mutationen hinsichtlich ihrer Auswirkungen auf die proliferative Fitness von Tumorzellen unter Nähstoffmangelzuständen wie Glukose- oder Glutaminentzug sowie einer möglichen Inhibition von p73 zu untersuchen. Verwendet wurde die humane Kolonkarzinomzelllinie HCT116, welche mittels CRISPR/Cas9 derart modifiziert wurde, dass eine Library aller möglichen Mutationen am Hotspot Codon 175 durch Rekombination eingesetzt werden konnte. Nach einer medikamentösen Behandlung oder einem Nährstoffentzug erfolgte die Extraktion von genomischer DNA, welche mittels PCR amplifiziert und anschließend sequenziert wurde, sodass eine Anreicherung oder Depletion von Zellen mit bestimmten Mutationen aufgezeigt werden konnte. Diese Depletion oder Anreicherung führte zur Charakterisierung von p53-Mutationen als WT-like, LOF oder pLOF, jedoch wurde für keine der TP53R175-Mutationen ein GOF nachgewiesen. Zur Analyse des GOF-Effekts in Bezug auf die Inhibition von p73 wurden die Isoformen TAp73α oder TAp73β Doxycyclin-induzierbar überexprimiert. Hier konnte für keine der TP53R175-Mutationen ein GOF hinsichtlich einer Inhibition von p73 nachgewiesen werden. Diese Arbeit bestätigt die unterschiedlichen Auswirkungen verschiedener Aminosäurenänderungen im p53-Protein bezüglich der Überlebensfähigkeit in Nähstoffmangelzuständen.
title: Optochemical Regulation of mRNA-Based Processes
Creators: name: Zhang, Lei
Publisher: name: Philipps-Universität Marburg
Year: 2023
Subjects: Chemistry & allied sciences
Chemie

description: Optochemical tools serve as potent instruments for the modulation of RNA-based processes. This thesis
introduces innovative development in the optochemical control of RNA splicing and translation regulation,
utilizing photoswitchable small molecules and peptide nucleic acids (PNAs).
In one part of this thesis (Chapter 3.1 and 3.3), an approach involving visible light-responsive peptide nucleic
acids (PNAs) for the manipulation of oligonucleotide hybridization was introduced. The synthesis of these
PNAs involved the conjugation with photoswitches (ortho-tetrafluoroazobenzene (oF4Azo), hemithioindigo,
and spiropyran). The subsequent synthesis and detailed photochemical characterization were expounded
upon. The studies revealed the promising attributes of oF4Azo-PNA conjugates, including rapid and reversible
isomerization, remarkable thermal stability, high isomer conversion, and sensitivity to visible-light irradiation.
Through melting experiments and strand-displacement assays, the investigation explored light-controlled
oligonucleotide hybridization, showing modest yet discernible differences induced by light. Combining
oF4Azo-PNAs with cell-penetrating peptides (CPPs) yielded light-responsive antisense agents for use in living
cells. With distinct goals of redirecting mRNA splicing and mimicking microRNA to inhibit cancer cell growth,
the PNA-CPPs demonstrated favorable outcomes. However, it was observed that the degree of light
controllability was limited. The subsequent development of cyclic PNAs was introduced, alongside various
synthetic approaches. Studies indicated that the ring size influenced oligonucleotide hybridization.
Another part of this thesis (Chapter 3.2) delved into the development of reversible mRNA splicing regulation
through photoswitchable small molecules. The synthesis and comprehensive photochemical analysis of
synthesized molecules were meticulously detailed. The best compound, Me-oF2Azo-BOX, exhibited rapid and
reversible photoisomerization, good thermal stability, and significant differences in enhancing exon inclusion
in splicing between photostationary states. This studies underscored its capability to achieve real-time
conditional control at both mRNA and protein levels, which could be reversibly regulated by light. Molecular
mechanisms of action were further elucidated.
Additional file 1 of Ethnic differences in the association between age at diagnosis of diabetes and the risk of cardiovascular complications: a population-based cohort study
Creators: name: Ke, Calvin
name: Stukel, Thérèse A.
name: Thiruchelvam, Deva
name: Shah, Baiju R.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: Additional file 1: Table S1. Outcome definitions used in the study. Table S2. Hazard ratios of peripheral revascularization and lower extremity amputation for (1) Chinese and South Asian adults compared with the general population (reference), stratified by age at diagnosis category; and (2) young-onset diabetes (YOD) and usual-onset diabetes (UOD) compared with matches without diabetes (reference), stratified by ethnicity. Table S3. Sensitivity analysis using Fine and Gray subdistribution hazard competing risk model. Table S4. Sensitivity analysis including an adjustment term for calendar year. Figure S1. Causal diagram depicting the clinically significant relationships among age at diagnosis (exposure), cardiovascular complications (outcome), and other variables. Figure S2. Hazard ratios of cardiovascular events among adults with YOD and UOD versus matches without diabetes in Ontario, Canada, stratified by ethnicity.
title: Mitteilungen aus dem pharm.-chem. Laboratorium der technischen Hochschule in Braunschweig Jahrgang 8. 1906
Creators: name: Pharmazeutisch-Chemisches Laboratorium Braunschweig
name: Pharmaceutisches Institut Braunschweig
Publisher: name: Laboratorium
Year: 1906
Subjects: subject: 615

description: Mitteilungen aus dem Pharm.-Chem. Laboratorium der Technischen Hochschule in Braunschweig, vol. 8
title: Mitteilungen aus dem pharm.-chem. Laboratorium der technischen Hochschule in Braunschweig Jahrgang 2. 1900
Creators: name: Pharmazeutisch-Chemisches Laboratorium Braunschweig
name: Pharmaceutisches Institut Braunschweig
Publisher: name: Laboratorium
Year: 1900
Subjects: subject: 615

description: Mitteilungen aus dem Pharm.-Chem. Laboratorium der Technischen Hochschule in Braunschweig, vol. 2
title: Mitteilungen aus dem pharm.-chem. Laboratorium der technischen Hochschule in Braunschweig Jahrgang 3. 1901
Creators: name: Pharmazeutisch-Chemisches Laboratorium Braunschweig
name: Pharmaceutisches Institut Braunschweig
Publisher: name: Laboratorium
Year: 1901
Subjects: subject: 615

description: Mitteilungen aus dem Pharm.-Chem. Laboratorium der Technischen Hochschule in Braunschweig, vol. 3
Alien chromatin from Hordeeae grasses enhances the compatibility of Epichloë endophyte symbiosis with the hexaploid wheat Triticum aestivum
Creators: name: Simpson, Wayne
name: Tsujimoto, Hisashi
name: Hume, David
name: Johnson, Richard
Publisher: name: AgResearch
Year: 2024
Subjects: classificationCode: 3108
subject: Plant biology

description: The inoculation of Epichloë endophytes into modern cereals, resulting in systemic infection, depends on the genetics of both the host and the endophyte strain deployed. Until very recently, the only modern cereal to have been infected with Epichloë, in which normal phenotype seed-transmitted associations were achieved, is rye (Secale cereale). Whilst minor in-roads have been achieved in infecting hexaploid wheat (Triticum aestivum), the phenotypes of these associations have all been extremely poor, including host death and stunting. To identify host genetic factors that may impact the compatibility of Epichloë infection in wheat, wheat–alien chromosome addition/substitution lines were inoculated with Epichloë, and the phenotypes of infected plants were assessed. Symbioses were identified whereby infected wheat plants were phenotypically like uninfected controls. These plants completed their full lifecycle, including the vertical transmission of Epichloë into the next generation of grain, and represent the first ever compatible wheat–Epichloë associations to be created.
Additional file 1 of Parental perspectives of episodic irritability in an ultra-rare genetic disorder associated with NACC1
Creators: name: Schoch, Kelly
name: McConkie-Rosell, Allyn
name: Walley, Nicole
name: Bhambhani, Vikas
name: Feyma, Timothy
name: Pizoli, Carolyn E.
name: Smith, Edward C.
name: Tan, Queenie K.-G.
name: Shashi, Vandana
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Science Policy
subject: Mental Health
subject: Computational Biology

description: Additional file 1. Parental Narrative Prompts.
title: Mitteilungen aus dem pharm.-chem. Laboratorium der technischen Hochschule in Braunschweig Jahrgang 5. 1903
Creators: name: Pharmazeutisch-Chemisches Laboratorium Braunschweig
name: Pharmaceutisches Institut Braunschweig
Publisher: name: Laboratorium
Year: 1903
Subjects: subject: 615

description: Mitteilungen aus dem Pharm.-Chem. Laboratorium der Technischen Hochschule in Braunschweig, vol. 5
title: Mitteilungen aus dem pharm.-chem. Laboratorium der technischen Hochschule in Braunschweig Jahrgang 6. 1904
Creators: name: Pharmazeutisch-Chemisches Laboratorium Braunschweig
name: Pharmaceutisches Institut Braunschweig
Publisher: name: Laboratorium
Year: 1904
Subjects: subject: 615

description: Mitteilungen aus dem Pharm.-Chem. Laboratorium der Technischen Hochschule in Braunschweig, vol. 6
Additional file 1 of Minimally invasive medial femoral approach to total knee arthroplasty improves short-term outcomes compared to the standard medial parapatellar approach: a systematic review and meta-analysis
Creators: name: Yang, Xin
name: Cheng, Qing-hao
name: Yang, Yong-ze
name: Zhang, An-ren
name: Fan, Hua
name: Guo, Hong-zhang
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences

description: Additional file 1: Retrieval Policy.
Energy conservation of small water to water heat pump assisted by solar collector for residentialapplication
Creators: name: A. KAEWPRADAP
name: S. SANITJAI
Publisher: name: Thai Society of Mechanical Engineers (TSME)
Year: 2018
Subjects: Heat pump
Solar collector
ASHRAE 93-77
EN255-3
COP

description: Journal of Research and Applications in Mechanical Engineering (JRAME), 6, 1, 21-28
East, west, is home the best? Eastern European immigrant women in northern Italy in the care sector: the impact of origins on the right to work
Creators: name: Ferrari, Maria
Publisher: name: Eurac Research
Year: 2024

description: Despite international frameworks, Italian women continue to face challenges related to the fundamental right to work: this issue becomes even more complex for immigrant women. In the care and healthcare sectors of northern Italy, women of Eastern European origins experience a connection between gender, immigration background, and labour rights. How is their right to work impacted? Previous research and interviews with key figures can help us answer this question.
Social policy dynamics in Iran. A critical study of the post-1979 revolutionary era
Creators: name: Bagheri, Yaser
Publisher: name: Universität Bremen
Year: 2024
Subjects: subject: social policy
subject: Iran
subject: 300

description: This research examines the dynamics of social policies in Iran over the 45 years following the 1979 revolution. During this period, welfare policies have fluctuated significantly and been subject to various contradictory analyses. Researchers often present conflicting views by focusing on specific aspects. The study critiques the unified approach to understanding the post-revolutionary period, emphasizing the need to consider the complex interplay of various factors. By reviewing changes related to economic indicators, socio-political factors, and dominant ideologies, seven distinct phases were identified: 1. Mustazafin Matters, Revolution, and War (1979-1988) 2. The Neoliberal Shift (1989-1996) 3. The Social Security System (1997-2004) 4. Welfare Expansion based on Oil Revenues (2005-2008) 5. Cash Transfer under Intensified Sanctions (2009-2012) 6. Unstable Recovery and Hope (2013-2016) 7. Despair and Drastic Adjustments (2017–2024) Each phase exhibits unique policy characteristics, providing a comprehensive understanding of social policy changes. This approach enables comparative analysis, revealing that social security has been the most dynamic policy area, while housing policies have remained relatively passive. The research highlights the instability of the post-revolutionary period, marked by fluctuating government revenues, external conflicts, and varying international relations. The methodology employs qualitative analysis, supplemented by secondary data and expert interviews, to ensure robustness and validity. The findings indicate that multiple internal and external events and significant fluctuations in Iran's conditions preclude a single-theory explanation for the post-revolutionary period. Social policy changes in Iran result from these diverse and dynamic contextual factors rather than a specific collective will or the agenda of any particular political party or social movement.
Additional file 1 of Engaging community members to ensure culturally specific language is used in research: should I use gay, queer, MSM, or this other new acronym?
Creators: name: Rubini, Kyle
name: Al-Bakri, Taim
name: Bridel, William
name: Clapperton, Andrew
name: Greaves, Mark
name: Hill, Nolan E.
name: Labrecque, Max
name: MacDonagh, Richard
name: Miguel, Glenndl
name: Orvis, Shane
name: Osbourne-Sorrell, Will
name: Randall, Taylor
name: Reid, Marco
name: Rosser, Andrew
name: Presseau, Justin
name: Vesnaver, Elisabeth
Publisher: name: figshare
Year: 2023
Subjects: subject: Sociology
subject: FOS: Sociology

description: Additional file 1. Decisions and rationale of the Expanding Donation in Canada study team regarding language to describe the communities impacted by the MSM donor criteria.
Performance improvement of solar air heater with v-baffles on absorber plate
Creators: name: P. HOONPONG
name: S. SKULLONG
Publisher: name: Thai Society of Mechanical Engineers (TSME)
Year: 2018
Subjects: V-baffle
Solar air heater
Artificial roughness
Heat transfer

description: Journal of Research and Applications in Mechanical Engineering (JRAME), 6, 1, 29-39
sj-pdf-1-pus-10.1177_09636625221109730 – Supplemental material for South Koreans’ responses to evolution and creationism: A survey and its implications
Creators: name: Park, Hyung Wook
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications
subject: Science Policy

description: Supplemental material, sj-pdf-1-pus-10.1177_09636625221109730 for South Koreans’ responses to evolution and creationism: A survey and its implications by Hyung Wook Park in Public Understanding of Science
Influence of Parenting Styles on the Decision-Making and Problem-Solving Strategies of Primary School Students Aged 5–8 Years
Creators: name: MANPREET KAUR
Publisher: name: Monash University
Year: 2019
Subjects: Education

description: This study aimed to discover the influence of parenting styles on decision making and problem solving of primary school students aged 5–8 years students. This research was a qualitative interpretivist study and used Rogoff’s three planes of analysis from a sociocultural perspective to analyse the influence of parenting styles on the decision making and problem solving of the students. No direct correlation was found between parenting style and decision making and problem solving, but it is possible they are related in a wider context.
Additional file 1 of Analysis of differentially expressed genes discovers Latroeggtoxin VI-induced changes and SYNJ1 as a main target in PC12 cells
Creators: name: Yu, Dianmei
name: Wang, Haiyan
name: Lei, Zhixiang
name: Zhai, Yiwen
name: Chen, Si
name: Sun, Minglu
name: Yin, Panfeng
name: Wang, Xianchun
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Additional file 1
Investigation on profile of slots machined by electrochemical milling with hollow electrode
Creators: name: J. PATTAVANITCH
Publisher: name: Thai Society of Mechanical Engineers (TSME)
Year: 2018
Subjects: Electrochemical machining
Slot milling
BEM
Modelling

description: Journal of Research and Applications in Mechanical Engineering (JRAME), 6, 1, 40-49