cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
CURCUMIN REDUCES NITROTYROSINE DEPOSITION AND ERK1/2 ACTIVATION AND AMELIORATES EXPERIMENTAL COLORECTAL ADENOCARCINOMA
Creators: name: Bounaama, Abdelkader
name: Djerdjouri, Bahia
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Increasing evidence suggest that peroxynitrite (ONOO-) can activates Raf/MEK/ERK signalling pathway which is associated with cell proliferation, apoptosis inhibition and drug resistance in malignancies, including colorectal cancer. This work investigates the effect of short curcumin treatment on peroxynitrite formation and ERK1/2 activation in an experimental colorectal adenocarcinoma. Colonic precarcinogen 1, 2-dimethylhydrazine (DMH) (20mg/kg body weight) was weekly injected subcutaneously to mice for the first 10 weeks and animals were sacrificed at the 32th week of experiment. Curcumin an antioxidant of turmeric (Curcuma longa L.) (20mg/kg body weight) was provided orally from the 30th to 32th week. The results showed that DMH induced colorectal adenocarcinoma in all treated mice and overexpression of iNOS transcripts (4.3±1.65 fold of control value). Furthermore, histochemical analysis showed a strong nitrotyrosine deposition (score 3) and ERK1/2 phosphorylation in tumor gland (score 3). Curcumin induced apoptosis of adenocarcinoma cells (About 75% increase, compared to DMH group) and strongly inhibited nitrotyrosine deposition (shift from score 3 to score 1) and ERK1/2 phosphorylation (shift from score 3 to score 1). In conclusion, our results showed that anticancer potential of cucrcumin on advanced colorectal adenocarcinoma is driven at least in part by inhibition of nitrosative stress and ERK activation.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Picrops usingeri La Rivers 1952
Creators: name: Peralta-Argomeda, Jorge Luis
name: Rodrigues, Juliana Mourão Dos Santos
name: Huamantinco-Araujo, Ana
name: Moreira, Felipe Ferraz Figueiredo
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Naucoridae
Picrops
Picrops usingeri

description: Picrops usingeri La Rivers, 1952
 Geographic distribution. Guyana, Suriname, French Guiana, Brazil (La Rivers 1952), Peru (Peralta-Argomeda 2011).
 Distribution in Peru. Madre de Dios (Peralta-Argomeda 2011; Sites 2023).
 Notes. Sites et al. (2017) recorded undetermined male specimens of Picrops from Peru and noted that they were probably P. usingeri (La Rivers, 1952). Subsequently, Sites (2023) recorded P. usingeri from Madre de Dios department after collecting females.
description: Published as part of Peralta-Argomeda, Jorge Luis, Rodrigues, Juliana Mourão Dos Santos, Huamantinco-Araujo, Ana & Moreira, Felipe Ferraz Figueiredo, 2024, Checklist of the aquatic and semiaquatic bugs (Hemiptera: Heteroptera: Gerromorpha, Leptopodomorpha & Nepomorpha) of Peru, pp. 1-72 in Zootaxa 5467 (1) on page 35, DOI: 10.11646/zootaxa.5467.1.1, http://zenodo.org/record/11613746
Dolichoderus brevis Santschi 1920
Creators: name: Saroj, S.
name: Mandi, A.
name: Basak, N.
name: Mandal, P.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Dolichoderus
Dolichoderus brevis

description: Dolichoderus brevis Santschi, 1920
Figs 6–8
 MATERIAL EXAMINED. India: West Bengal, South Jayanti Beat, 26°39'528" N, 089°35'799" E, 383.4ft, 03.XII 2018, 2 workers, leg. S. Sheela (Reg. No. 24693/H3).
DISTRIBUTION. India (new record), Laos.
description: Published as part of Saroj, S., Mandi, A., Basak, N. & Mandal, P., 2024, THE BUXA TIGER RESERVE AS A ' HOT SPOT' OF ANT DIVERSITY IN WEST BENGAL STATE (HYMENOPTERA: FORMICIDAE), pp. 16-22 in Far Eastern Entomologist 503 on page 18, DOI: 10.25221/fee.503.3, http://zenodo.org/record/13260758
Procryphocricos pilcopata Sites & Shepard 2015
Creators: name: Peralta-Argomeda, Jorge Luis
name: Rodrigues, Juliana Mourão Dos Santos
name: Huamantinco-Araujo, Ana
name: Moreira, Felipe Ferraz Figueiredo
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Naucoridae
Procryphocricos
Procryphocricos pilcopata

description: Procryphocricos pilcopata Sites & Shepard, 2015
 Geographic distribution. Peru (Sites & Shepard 2015).
 Distribution in Peru. Cusco (Sites & Shepard 2015).
description: Published as part of Peralta-Argomeda, Jorge Luis, Rodrigues, Juliana Mourão Dos Santos, Huamantinco-Araujo, Ana & Moreira, Felipe Ferraz Figueiredo, 2024, Checklist of the aquatic and semiaquatic bugs (Hemiptera: Heteroptera: Gerromorpha, Leptopodomorpha & Nepomorpha) of Peru, pp. 1-72 in Zootaxa 5467 (1) on page 35, DOI: 10.11646/zootaxa.5467.1.1, http://zenodo.org/record/11613746
Gesomyrmex spatulatus Cole 1949
Creators: name: Saroj, S.
name: Mandi, A.
name: Basak, N.
name: Mandal, P.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Gesomyrmex
Gesomyrmex spatulatus

description: Gesomyrmex spatulatus Cole, 1949
 MATERIAL EXAMINED. India: West Bengal, District Alipurduar, Buxa Tiger Reserve, Poro Eco Park, 26°32'57.1" N, 89°27'30.0"E, 144 ft, 05.XII 2018, 3 workers, leg. S. Sheela; same locality, 30.III 2017, 7 workers, leg. Jayanti & S. Sheela (Reg. No. 19738/H3,19739/H3,19741/H3-19748/H3).
DISTRIBUTION. India: Assam, West Bengal (new record), Singapore.
description: Published as part of Saroj, S., Mandi, A., Basak, N. & Mandal, P., 2024, THE BUXA TIGER RESERVE AS A ' HOT SPOT' OF ANT DIVERSITY IN WEST BENGAL STATE (HYMENOPTERA: FORMICIDAE), pp. 16-22 in Far Eastern Entomologist 503 on page 19, DOI: 10.25221/fee.503.3, http://zenodo.org/record/13260758
Training Manual for Agro-Processing, Productivity Enhancement and Livelihood Improvement Support Project Women and Youth Empowerment Programme.
Creators: name: Centre for Dryland Agriculture (CDA)
Publisher: name: Centre for Dryland Agriculture, Bayero University, Kano
Year: 2019

description: This training manual is developed for training of women and youths under the Federal Government of Nigeria Productivity Enhancement and Livelihood Improvement Support Project Women and Youths Empowerment Programme. The manual is developed by the Centre for Dryland Agriculture in collaboration with the Departments of Agricultural Economics and Extension, Agronomy, Animal Science, Fisheries and Aquaculture and Food Science and Technology in the Faculty of Agriculture in Bayero University. Kano.

This manual is expected to be used in building the capacity of women and youths who will be trained in the Rice, Poultry and Aquaculture value chain. This training manual is need based and is based on the many years of experiences of staff in the different activities of the rice, poultry and aquaculture value chains. The manual is a tool for the trainers describing the proposed training methodology, objectives, related activities and exercises. It can be adopted to different target audience.

The manual is organised in two parts; A general manual and curriculum for all the trainers and the handout for each value chain. All the trainees are expected to participate in Agribusiness Management; the first component of the manual which will be taken in plenary two to three hours daily. The trainees are expected to acquire Agribusiness Management skills like Value creation, marketing, funds and financial management, leadership and business plan development. The subsequent components of the manual address the fish, poultry and rice value chains with classroom lectures but more emphasis on practical sessions at the poultry farm, fishponds and rice mill.
MITOCHONDRIAL DEACETYLATION IS AN ACTIVATING SIGNAL MEDIATED BY SIRTUIN 3 FOR METABOLISM-SECRETION COUPLING IN PANCREATIC BETA CELLS
Creators: name: De Marchi, Umberto
name: Hermant, Aurélie
name: Dayon, Loïc
name: Núñez Galindo, Antonio
name: Thevenet, Jonathan
name: Santo Domingo, Jaime
name: Kussmann, Martin
name: Wiederkehr, Andreas
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Metabolism-secretion coupling describes the molecular mechanism linking nutrient sensing to insulin secretion in pancreatic beta-cells. This process requires the activation of mitochondria, leading to ATP production and coupling factors, which amplify secretion. Several mitochondrial derived coupling factors were proposed but the mechanisms linking mitochondria to the amplification of insulin exocytosis remain elusive. Little attention has been devoted to the regulation by mitochondrial acetylation, despite the crucial role of mitochondria and the expression of matrix NAD-dependent deacethylases (mitochondrial sirtuins) in beta-cell.
To determine the impact of mitochondrial acetylation on metabolism-secretion coupling in insulin-secreting cells, we have combined functional investigations with quantitative proteomics in pancreatic INS1E beta-cells, devoid of the mitochondrial deacetylase Sirtuin-3 (Sirt3). Glucose-stimulated Sirt3-KO cells showed reduced Ca2+ rises compared to control cells. Basal oxygen consumption was increased, ATP-synthase dependent respiration decreased and the second phase of ATP production absent. Impaired mitochondrial function due to unbalanced acetylation was reflected in the aberrant insulin secretion. Quantitative proteomics showed significant difference in 39 mitochondrial lysine acetylation sites. Six glucose-stimulated proteins were identified with differential acetylation levels.
Dynamic mitochondrial acetylation mediated by Sirt3 regulates metabolism in glucose-stimulated beta cells by controlling mitochondrial ATP production and Ca2+ homeostasis.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Cryphocricos fittkaui De Carlo 1967
Creators: name: Peralta-Argomeda, Jorge Luis
name: Rodrigues, Juliana Mourão Dos Santos
name: Huamantinco-Araujo, Ana
name: Moreira, Felipe Ferraz Figueiredo
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Naucoridae
Cryphocricos
Cryphocricos fittkaui

description: Cryphocricos fittkaui De Carlo, 1967
 Geographic distribution. Peru (De Carlo 1967a).
 Distribution in Peru. Huánuco (De Carlo 1967a).
description: Published as part of Peralta-Argomeda, Jorge Luis, Rodrigues, Juliana Mourão Dos Santos, Huamantinco-Araujo, Ana & Moreira, Felipe Ferraz Figueiredo, 2024, Checklist of the aquatic and semiaquatic bugs (Hemiptera: Heteroptera: Gerromorpha, Leptopodomorpha & Nepomorpha) of Peru, pp. 1-72 in Zootaxa 5467 (1) on page 35, DOI: 10.11646/zootaxa.5467.1.1, http://zenodo.org/record/11613746
Robust - Integrated coating and cleaning concept for fouling control on offshore structures
Creators: name: Heusinger Von Waldegge, Tim
name: Stübing, Dorothea
name: Daehne, Bernd
name: Kuhn, Lukas
name: Felder, Thorsten
name: Kensbock, Philip
name: :Unav
Publisher: name: Fraunhofer-Gesellschaft
Year: 2022

description: Field tests ▪ Biofouling is an unsolved problem in offshore industry, it induces a lot of work and therefore high costs ▪ It causes problems, when the welding seams of offshore-structures have to be controlled by divers regularly ▪ The industrial standard coatings should be replaced by more efficient non-biocidal systems Summarized project goals: Less fouling, easier cleanings, mechanical stability of the coating, no input of biocides into the environment and lower costs at maintenance
ROS increases glycolysis in Acute Myeloid Leukaemia via overexpression of PFKFB3
Creators: name: Robinson, Andy
name: Kreuser, Sandra
name: Davies, Sara
name: Darley, Richard
name: Tonks, Alex
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Acute Myeloid Leukaemia (AML) is a heterogeneous haematological malignancy often characterised with RAS mutations.1 Mutant RAS increases production of reactive oxygen species (ROS), via constitutive activation of NADPH oxidase (NOX), engendering a pro-proliferative phenotype.2 NOX-derived ROS overproduction occurs in >60% of AML patients and is associated with increased proliferation.3 Using transcriptome analysis we show that ROS promotes expression of glycolytic genes. To functionally confirm this, ROS levels were modulated in AML cell lines and haematopoietic progenitor cells expressing mutant RAS (HPC-RAS);2 corresponding changes  in cellular glucose uptake and lactate output were measured using a glucose bio-probe4 and biochemical assay respectively. Protein expression levels of glycolytic genes were investigated using western blotting. Here we show that HPC-RAS and AML cell lines show significant ROS induced increases in glucose consumption (~4-fold) and extracellular lactate output (~4-fold) and that these changes are mediated by ROS dependent changes in protein expression of a key regulatory glycolytic enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase3 (PFKFB3). Additionally ROS associated changes in protein expression of other key glycolytic genes were also observed in AML cell lines. These data support a role for ROS in promoting glycolysis in AML.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
N-acetyl ornithine deacetylase is a moonlighting protein and is involved in the adaptation of Entamoeba histolytica to nitrosative stress
Creators: name: Ankri, Serge
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Adaptation of the parasite Entamoeba histolytica to nitric oxide (NO) may be essential for the parasite's survival in its host. In order to obtain insight into the mechanism of E. histolytica's adaptation to NO, E. histolytica trophozoites were progressively adapted to increasing concentrations of S-nitrosoglutathione (GSNO) up to a concentration of 110 µM. These NO-adapted trophozoites (NAT) were more resistant to an acute exposure of 350μM GSNO and were better at invading porcine colon explants than wild-type trophozoites. N-acetyl ornithine deacetylase (NAOD) was among the 208 genes that were upregulated in NATs. NAOD catalyzes the deacylation of N-acetyl-L-ornithine to yield ornithine and acetate. Overexpression of NAOD resulted in significant overproduction of putrescine and in a better adaptation to nitrosative stress (NS). Surprisingly, overexpression of a catalytically inactive NAOD (mNAOD) resulted in a better adaptation to NS but did not result in putrescine overexpression. These results suggest that NAOD is a moonlighting protein. The binding of NAOD or mNAOD to glyceraldehyde 3-phosphate dehydrogenase (GAPDH) prevents the formation of putative toxic high molecular weight GAPDH species and the absence of these species may underlie the parasite’s ability to survive NS.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Rhopalomastix rothneyi Forel 1900
Creators: name: Saroj, S.
name: Mandi, A.
name: Basak, N.
name: Mandal, P.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Rhopalomastix
Rhopalomastix rothneyi

description: Rhopalomastix rothneyi Forel, 1900
 MATERIAL EXAMINED. India: West Bengal, District Alipurduar, Buxa Tiger Reserve, East Damanpur Range, 26°37'067" N, 89°33'633" E, 27.III 2019, 5 workers, leg. Arnab Mandi (Reg. No. 23389/H3)
DISTRIBUTION. India (Karnataka, Sikkim, West Bengal), Sri Lanka, New Guinea, Australia.
REMARKS. This species was described based on queen from Barrackpore, West Bengal. Our specimens are collected from the nest under the bark of Sal tree.
description: Published as part of Saroj, S., Mandi, A., Basak, N. & Mandal, P., 2024, THE BUXA TIGER RESERVE AS A ' HOT SPOT' OF ANT DIVERSITY IN WEST BENGAL STATE (HYMENOPTERA: FORMICIDAE), pp. 16-22 in Far Eastern Entomologist 503 on page 19, DOI: 10.25221/fee.503.3, http://zenodo.org/record/13260758
Differential response of Fanconi anemia hematopoietic stem and progenitor cells to oxidative and oncogenic stresses
Creators: name: Pang, Qishen
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Members of the Fanconi anemia (FA) pathway are involved in DNA damage response. By employing an in vivo stress-response model expressing the Gadd45b-luciferase transgenic cassett, we show here that hematopoietic stem and progenitor cells (HSPCs) from mice deficient for the FA gene Fanca or Fancc differentially responded to oxidative and oncogenic stresses. Compared to wild-type controls, Fanca-/- or Fancc-/- HSPCs exhibited a persistent response to oxidative stress. Mechanistically, we demonstrated that accumulation of unrepaired DNA damage, particularly in oxidative damage-sensitive genes, was responsible for the long-lasting response in FA HSPCs. In contrast, using two inducible models of oncogenic activation (LSL-K-rasG12D and MycER), we identify a short-lived response of FA HSPCs to oncogenic insults. Loss of Fanca or Fancc impaired oncogenic stress-induced senescence (OIS), and genetic correction of Fanca or Fancc deficiency restored OIS in HSPCs. Furthermore, FA deficiency compromised K-rasG12D-induced arginine methylation of p53 mediated by PRMT5.  Finally, forced expression of PRMT5 in HSPCs from Fanca-/-;K-rasG12D mice prolonged oncogenic response and delayed leukemia development in recipient mice. Taken together, our study demonstrates differential responses of HSPCs to oxidative and oncogenic stresses and identifies the FA pathway as an integral part of this versatile cellular mechanism.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Cryphocricos peruvianus De Carlo 1940
Creators: name: Peralta-Argomeda, Jorge Luis
name: Rodrigues, Juliana Mourão Dos Santos
name: Huamantinco-Araujo, Ana
name: Moreira, Felipe Ferraz Figueiredo
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Naucoridae
Cryphocricos
Cryphocricos peruvianus

description: Cryphocricos peruvianus De Carlo, 1940
 Geographic distribution. Ecuador (Sites et al. 2003), Peru (De Carlo 1940).
 Distribution in Peru. Huánuco (Roback 1966), Junín (De Carlo 1940), unknown department (Usinger 1947).
 Note. The identification of the naucorid material reported by Roback (1966) is questionable (Sites & Shepard 2015).
description: Published as part of Peralta-Argomeda, Jorge Luis, Rodrigues, Juliana Mourão Dos Santos, Huamantinco-Araujo, Ana & Moreira, Felipe Ferraz Figueiredo, 2024, Checklist of the aquatic and semiaquatic bugs (Hemiptera: Heteroptera: Gerromorpha, Leptopodomorpha & Nepomorpha) of Peru, pp. 1-72 in Zootaxa 5467 (1) on page 35, DOI: 10.11646/zootaxa.5467.1.1, http://zenodo.org/record/11613746
Colobopsis cotesii Forel 1893
Creators: name: Saroj, S.
name: Mandi, A.
name: Basak, N.
name: Mandal, P.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Colobopsis
Colobopsis cotesii

description: Colobopsis cotesii Forel 1893
 MATERIAL EXAMINED. India: West Bengal, District Alipurduar, Buxa Tiger Reserve, North point, 26°43'597" N, 089°45'039" E, 03.XII 2018, 1 worker, leg. S. Sheela (Reg. No. 22247/H3).
DISTRIBUTION. India, China.
 REMARKS. This species was originally described from Mussoori Hills in India. It was later reported from Assam (Bingham 1903). After that it was recorded from Arunachal Pradesh, Assam, Meghalaya, Uttarakhand (Bharti et al., 2016) Here C. cotesii is found from an unknown tree trunk in the core area of Buxa reserve (new record for West Bengal).
description: Published as part of Saroj, S., Mandi, A., Basak, N. & Mandal, P., 2024, THE BUXA TIGER RESERVE AS A ' HOT SPOT' OF ANT DIVERSITY IN WEST BENGAL STATE (HYMENOPTERA: FORMICIDAE), pp. 16-22 in Far Eastern Entomologist 503 on page 19, DOI: 10.25221/fee.503.3, http://zenodo.org/record/13260758
Teda
Creators: name: Droe, Anj
Publisher: name: Database of Religious History (DRH)
Year: 2023

description: The Teda are a society of nomadic pastoralists part of a larger ethnic group known as “Tebu.” They reside primarily in high plateaus of the Tibesti Mountains in what is now the Republic of Chad (Simpson 2011:1). This entry focuses on the Teda of Tibesti around the time of 1925. At this time, this region was part of French Equatorial Africa and therefore under the political control of France. Although the Teda live in a highly remote area, Tibesti is located along important caravan routes that have historically given the Teda both control over trade and a high level of contact with other societies and religious groups. The majority of Teda are Muslim, having likely been converted early in the spread of Islam across Africa (Simpson 2011:7). Prayer is very important, as are certain holidays, such as Ramadan, and pilgrimages. Among the Teda, Islamic practices appear to have been largely syncretic with the traditional Teda religion practiced before conversion to Islam. However, during the time focus of this entry, influences from an Islamic missionary group resulted in more fundamental practices of Islam among the Teda. For the Teda, religious beliefs are inseparable from almost all aspects of social and political life. Therefore, this entry considers the religious group to be coterminous with the society at large.
Supplementary document for Active Image Optimization for Lattice Light Sheet Microscopy in Thick Samples - 6061235.pdf
Creators: name: Malivert, Maxime
name: Harms, Fabrice
name: Veilly, Cynthia
name: Legrand, Jerome
name: Li, Ziqiang
name: Bayer, Emmanuelle
name: Choquet, Daniel
name: Ducros, Mathieu
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary Notes and Figures
Effects of various types of cerium oxide nanoparticles on C. elegans healthspan
Creators: name: Cuff, Brittany
name: Manning, Molly
name: Erlichman, Joseph S.
name: Estevez, Ana Y.
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Cerium oxide (CeO2) nanoparticles (nanoceria) are potent antioxidants that are being explored as a potential therapeutic for oxidative stress diseases.   Nanoceria catalytically neutralize multiple types of reactive oxygen species. However, both therapeutic and toxic effects of CeNPs have been reported1-3. We hypothesize that these disparate reports are due to small chemical differences in each type of particle arising from the synthetic process4. Due to its short lifespan and easily observable behaviors which serve as robust indicators of health, we used the nematode C. elegans to examine, in parallel, the effects of differing types of cerium oxide nanoparticles on animal healthspan.  We fed the animals the different types of nanoceria and analyzed fertility, egg-laying, defecation, and thrashing behaviors. We also assessed the ability of the worm to withstand thermal stress (thermotolerance).  None of the nanoparticles tested had any significant effects on the behaviors analyzed, suggesting that nanoceria are not toxic at the doses tested. Interesting, all of the nanoparticles significantly improved worm thermotolerance, suggesting that the nanoceria may be protective under stressful conditions.  Future studies will further assess the ability of nanoceria to be protective in worm models of oxidative stress.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Colobopsis vitrea subsp. angustula
Creators: name: Saroj, S.
name: Mandi, A.
name: Basak, N.
name: Mandal, P.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Colobopsis
Colobopsis vitrea
Colobopsis vitrea angustula (emery, 1925)

description: Colobopsis vitrea angustula (Emery, 1925)
 MATERIAL EXAMINED. India: West Bengal, District Alipurduar, Buxa Tiger Reserve, East Damanpur Range, 26°37'067" N, 089°33'633" E, 27.III 2019, 1 worker, leg. S. Sheela (Reg. No. 32547/H3).
DISTRIBUTION. India, Bangladesh, Singapore.
REMARKS. This taxon was described from Singapore as distinct species and later recorded from from Barrackpore (West Bengal) (Bingham, 1903) and Bangladesh (Hannan 2003). We also found this subspecies in West Bengal after a gap of 120 years from its first registration in India.
description: Published as part of Saroj, S., Mandi, A., Basak, N. & Mandal, P., 2024, THE BUXA TIGER RESERVE AS A ' HOT SPOT' OF ANT DIVERSITY IN WEST BENGAL STATE (HYMENOPTERA: FORMICIDAE), pp. 16-22 in Far Eastern Entomologist 503 on page 19, DOI: 10.25221/fee.503.3, http://zenodo.org/record/13260758
Determination of antioxidant activity of phytogenic substances via a yeast-based fluorescence assay
Creators: name: Bachinger, Diana
name: Wendner, Dominik
name: Schieder, Carina
name: Dohnal, Ilse
name: Schatzmayr, Gerd
name: Teichmann, Klaus
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Plant-derived phytogenic feed additives (PFAs) are used to improve health and performance of farm animals. One proposed mode of action is an antioxidative effect. In order to evaluate the intracellular antioxidative potential of PFAs in vitro, we developed a yeast-based assay and applied it to several different substances and mixtures.
 Yeast cells of the strain Saccharomyces cerevisiae were starved in phosphate buffered saline (PBS) for several days before they were incubated for 30 minutes with 2′,7′‑Dichlorofluorescein diacetate (DCFH, a cell permeable, non-fluorescent substance that becomes highly fluorescent upon oxidation). After washing away extracellular DCFH, the cells were transferred to 96-well microplates containing the different test substances and were subjected to oxidative stress by addition of 400 µM H2O2 for one hour. Fluorescence (excitation: 485 nm, emission: 528 nm) was quantified using a plate-reader. Controls included cells without test substance, cells without DCFH and cells without H2O2. Ascorbic acid (4 mM) served as positive control.
 As expected, the positive control reduced the fluorescence signal of the H2O2-stressed cells, proving that the assay is suitable for detecting antioxidant activity. Moreover, also some of the tested PFAs led to a reduced signal, thereby underlining the antioxidant capacity of selected PFAs on eukaryotic cells.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Plagiolepis pissina Roger 1863
Creators: name: Saroj, S.
name: Mandi, A.
name: Basak, N.
name: Mandal, P.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Plagiolepis
Plagiolepis pissina

description: Plagiolepis pissina Roger, 1863
 MATERIAL EXAMINED. India: West Bengal, Buxa Tiger Reserve, North Jayanthi beat, 26°40'914" N, 89°36'165" E, 504.6 ft, 03.XII 2018, 4 workers, leg S. Sheela (Reg No. 24684/H3).
DISTRIBUTION. India, Sri Lanka.
REMARKS. This species was reported from India (West Bengal) for the first time by Das & Sheela (2022). Here this species is also found in the Buxa reserve.
description: Published as part of Saroj, S., Mandi, A., Basak, N. & Mandal, P., 2024, THE BUXA TIGER RESERVE AS A ' HOT SPOT' OF ANT DIVERSITY IN WEST BENGAL STATE (HYMENOPTERA: FORMICIDAE), pp. 16-22 in Far Eastern Entomologist 503 on page 20, DOI: 10.25221/fee.503.3, http://zenodo.org/record/13260758
Ctenipocoris peruvianus
Creators: name: Peralta-Argomeda, Jorge Luis
name: Rodrigues, Juliana Mourão Dos Santos
name: Huamantinco-Araujo, Ana
name: Moreira, Felipe Ferraz Figueiredo
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Naucoridae
Ctenipocoris
Ctenipocoris peruvianus

description: Ctenipocoris peruvianus (La Rivers, 1974)
 Geographic distribution. Peru (La Rivers 1974).
 Distribution in Peru. Huánuco (La Rivers 1974).
description: Published as part of Peralta-Argomeda, Jorge Luis, Rodrigues, Juliana Mourão Dos Santos, Huamantinco-Araujo, Ana & Moreira, Felipe Ferraz Figueiredo, 2024, Checklist of the aquatic and semiaquatic bugs (Hemiptera: Heteroptera: Gerromorpha, Leptopodomorpha & Nepomorpha) of Peru, pp. 1-72 in Zootaxa 5467 (1) on page 35, DOI: 10.11646/zootaxa.5467.1.1, http://zenodo.org/record/11613746
Protective Effects of 10% Ethanolic Extract from Capsosiphon fulvescens against Ethanol-induced Oxidative Stress
Creators: name: Cho, Haneul
name: You, Yanghee
name: Park, Jeongjin
name: Kim, Soo-Il
name: Jun, Woojin
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: The consumption of alcohol, especially in the long-term, has the potential adverse effects that include development of alcohol-related liver disease. Oxidative stress is considered as one of the key mechanisms responsible for alcoholic liver damage. In the present study, the protective effects of 10% ethanolic extract (CF) from Capsosiphon fulvescens against ethanol-induced hepatotoxicity was investigated in HepG2 cells transfected with human CYP2E1 (HepG2/2E1).  The oxidative stress induced by ethanol caused a drastic decrease in cell viability with approximately 60%. This ethanol-induced cellular toxicity, however, was significantly reduced when the HepG2/2E1 cells were pretreated with CF. Hepatoprotective effects of CF against alcoholic damage were confirmed in male C57BL/6 mice. Mice (n=8 per group), which received CF (900 mg/kg b.w./day) with ethanol revealed the prevention of alcohol-induced hepatotoxicity as evidenced by the significant reductions of serum alanine and aspartate aminotransferase activities compared to ethanol-alone administered mice (5 g/kg b.w./day of ethanol).  Furthermore, CF enhanced antioxidant capacities with higher activities of SOD, catalase, glutathione-S-transferase, glutathione reductase, and glutathione peroxidase, and level of reduced glutathione. These results suggest that CF could be a candidate used for the prevention against various liver diseases induced by oxidative stress via elevating antioxidative potentials.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Camponotus selene Emery 1889
Creators: name: Saroj, S.
name: Mandi, A.
name: Basak, N.
name: Mandal, P.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Camponotus
Camponotus selene

description: Camponotus selene Emery 1889
 MATERIAL EXAMINED. India: West Bengal, Buxa Tiger Reserve, 26th Mile, Rajabhatkhava range (West), 25.III 2019, 2 workers, leg. A. Mandi (Reg. No. 25117/H3).
DISTRIBUTION. India (Arunachal Pradesh, Assam, Meghalaya, Maharashtra, West Bengal), Myanmar, China.
REMARKS. New for the Buxa Tiger Reserve species.
description: Published as part of Saroj, S., Mandi, A., Basak, N. & Mandal, P., 2024, THE BUXA TIGER RESERVE AS A ' HOT SPOT' OF ANT DIVERSITY IN WEST BENGAL STATE (HYMENOPTERA: FORMICIDAE), pp. 16-22 in Far Eastern Entomologist 503 on page 20, DOI: 10.25221/fee.503.3, http://zenodo.org/record/13260758
A New Family of Antioxidant Proteins:  Antioxidant Properties of the Chloride Intracellular Ion Channel Protein, CLIC1
Creators: name: Valenzuela, Stella M
name: Ali, Hala M
name: Al Khamici, Heba
name: Hossain, Khondker R
name: Jiang, Lele
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: The Chloride Intracellular Ion Channel (CLIC) family consists of six evolutionarily conserved protein members in vertebrates. These proteins are unusual, existing in cells as both soluble and membrane bound proteins. CLIC1 was first isolated from activated monocytes and extensively characterised as an ion channel protein, is expressed widely across human tissues (1). Its ion channel activity and membrane insertion are regulated by sterol and phospholipid membrane composition (2,3), as well as pH and redox. Given the bulk of cellular CLIC1 is in a soluble form, we recently demonstrated this soluble form possesses oxidoreductase enzymatic activity (4). Our current study demonstrates for the first time that CLIC1 possesses cellular antioxidant activity. We expressed recombinant CLIC1 in bacterial E. coli cells exposed to the oxidising agent H2O2. Expression of CLIC1 in the cells was sufficient to provide increased tolerance to H2O2, while a mutant form of the protein lacking the critical cysteine residue in the enzymatic active site did not. This demonstrates for the first time the direct cellular antioxidant activity by CLIC1 and confirms it is a moonlighting protein, with two distinct functions – a membrane spanning ion channel and an antioxidant oxidoreductase enzyme.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Trichonephila Dahl 1911
Creators: name: Fomichev, A. A.
name: Omelko, M. M.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Araneidae
Trichonephila

description: Genus Trichonephila Dahl, 1911
 REMARKS. Trichonephila with 26 species and subspecies is a relatively small genus of Araneidae, distributed in tropical and subtropical regions around the world with greatest diversity in sub-Saharan Africa (WSC, 2024). During long time Trichonephila was considered as a subgenus of Nephila Leach, 1815 but recently rased to genus rank (Kuntner et al., 2019).
description: Published as part of Fomichev, A. A. & Omelko, M. M., 2024, NEW FOR THE ASIAN PART OF RUSSIA TAXA OF SPIDERS (ARACHNIDA: ARANEI), pp. 12-20 in Far Eastern Entomologist 502 on page 13, DOI: 10.25221/fee.502.3, http://zenodo.org/record/13260776
Santian neijie jing 三天內解經
Creators: name: Kohn, Livia
Publisher: name: Database of Religious History (DRH)
Year: 2022

description: The “Scripture of the Inner Explanation of the Three Heavens” (DZ 1205), in two juan, is a text of the southern Celestial Masters that can be dated around the beginning of the Liu-Song dynasty. Its first juan, translated by S. Bokenkamp, expounds the basic worldview of the group, outlining the creation of the universe through the Dao and Lord Lao, the unfolding of the three major world religions—Daoism (east), Buddhism (west), and Yin-Yang practice (south)—and the development of the organization of the Celestial Masters. In terms of the latter, it emphasizes the replacement of the corrupt and despicable Six Heavens (the cosmology of the Confucian ritual system) with the pure and eminent Three Heavens of the Dao, made up of the three qi: original, beginning, and primordial. The three qi also gave rise to Lord Lao, who then created his own mother, the Jade Maiden of Mystery and Wonder (Xuanmiao yunü) from cosmic energies, then orchestrated his own birth and life. At the end of the latter, he moreover ordered Yin Xi to become the Buddha and thereby deliver the pure Dao to the western barbarians. The text provides an integrated worldview and represents as justification of Celestial Masters’ beliefs for the benefit of the Liu- Song court. The second juan deals more specifically with moral rules and theoretical doctrines, associated the Dao with nonaction and outlining details of zhai or purgations. It also presents a discussion of Daoism versus Buddhism in terms of greater and lesser vehicles, contrasting again the purity and eminence of the Dao with the more primitive and simple practices of Buddhists.
Brain oxidative stress in suicidality and other-directed aggressivity: identification of the NADPH oxidase NOX2 as a novel biomarker
Creators: name: Schiavone, Stefania
name: Trabace, Luigia
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Increasing evidence show a role of oxidative stress in suicidality and in other-directed aggressivity. However, few studies have been performed on the sources of ROS in these behavioural alterations.
 We first investigated possible NOX2 elevations in post-mortem brain samples of subjects who committed suicide compared to controls. NOX2 expression was significantly elevated in the cortex of suicidal subjects and its immunostaining was mainly detected in GABAergic neurons. A sustained increase in 8-hydroxy-2’–deoxyguanosine (8OhDG) expression and interleukin-6 immunoreactivity was also detected in the cortex of suicidal subjects. We then investigated the role of NOX2 in an unusual fatal case of cocaine-induced Excited Delirium Syndrome, characterized by extreme agitation, delirium and very aggressive behavior. A strong NOX2 immunoreactivity was found mainly in GABAergic neurons and astrocytes, as well as a significant expression of other markers of oxidative stress (8OhDG, HSP70, HSP90 and NF-kB) and apoptotic phenomena.
 Our results suggest NOX2-derived oxidative stress increase in the brain is involved in the neuropathological pathways leading to suicidal behaviour and, although through preliminary observations, other-directed aggressivity. These results might open innovative insights in the identification of new biomarkers considered predictive for aggressive behaviour and for its prevention.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Towards automated CAR-T Cell Manufacturing. Keeping up with Technological Advancement
Creators: name: Herbst, Laura
name: Erkens, Frederik
name: Hort, Simon
name: Bäckel, Niklas
name: Nießing, Bastian
name: Popp, Georg
name: Franz, Paul
name: König, Niels
name: Hudecek, Michael
name: Rafiq, Qasim
name: Goldrick, Stephen
name: Papantoniou, Ioannis
name: Schmitt, Robert H.
name: :Unav
Publisher: name: Fraunhofer-Gesellschaft
Year: 2023
Subjects: Automation
Cell therapy
CAR-T cells

description: The AIDPATH project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement no 101016909. The material presented and views expressed here are the responsibility of the author(s) only. The EU Commission takes no responsibility for any use made of the information set out.
TA'LIMNIRRAQAMLASHTIRISHNING MOHIYATI VA AHAMIYATI
Creators: name: Jurayev, Vohid
name: Turg'unova, Navbaxoroy
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqola raqamli texnologiyalar va ularning turli jabhalardagi ahamiyati haqida batafsil ma'lumot beradi. Raqamli texnologiyalar, signallarni uzluksiz spektr shaklida emas, balki diskret diapazonlarda ko‘rsatishga asoslangan texnologiyalardir. Ushbu texnologiyalarning soliq ma’murchiligida, iqtisodiy rivojlanishda va boshqa sohalarda qanday joriy etilishi va foydalanilishi tahlil etiladi. Shuningdek, raqamli texnologiyalarni qo‘llash orqali yirik ma’lumotlar tahlili, sun’iy intellekt, va boshqa ilg‘or texnologiyalar yordamida jarayonlarni avtomatlashtirish va shaffoflikni oshirish imkoniyatlari ko‘rib chiqiladi. Maqolada raqamli texnologiyalarning ijtimoiy-iqtisodiy sohalar rivojiga qo‘shgan hissasi ham yoritilgan.
p38MAPK is suppressed in AML (work in progress)
Creators: name: Hole, Paul
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Over-production of NOX-derived ROS is common in acute myeloid leukaemia (AML) and correlates with reduced responsiveness of the stress-activated kinase, p38MAPK.  We hypothesized that leukaemia cells regulate ROS accumulation in order to evade p38MAPK activation, which might otherwise compromise their proliferation or survival.  Here we show that p38MAPK signalling is suppressed in a sub-population of cells observed in nearly all primary AML patients and AML cells which we have termed ‘delta’ cells.  Consistent with our hypothesis, delta cells are highly resistant to exogenous oxidative stress.  Resistance to oxidative stress in delta cells was not due to differences in anti-oxidant capacity, but rather due to restricted entry of H2O2 through the plasma membrane.  Pharmacological studies using inhibitors of the aquaporin protein family suggested that members of this family governed H2O2 entry in delta cells. Expression of AQP3, a reported H2O2-permeable member of the aquaporin family, correlated with H2O2 permeability in a panel of AML cell lines. <>
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Protandim Treatment Causes Reversible Nuclear Translocation of Nrf-2 and Activation of the Antioxidant Response Element
Creators: name: Chevreau, Nathalie
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Protandim® is a natural supplement which activates antioxidant protective pathways through induction of the Nrf-2 transcription factor. We set out to elucidate the mechanism and kinetics by which this occurs through a series of cell-based assays.  AREc32 cells, containing an Nrf2-responsive reporter gene encoding luciferase, were treated with Protandim.  A time dependent evaluation of Protandim treatment showed an increase in ARE-controlled reporter gene expression starting at 12 hours, and peaking at 24 hours post-treatment. To better understand the kinetics of Nrf-2 subcellular localization, immunofluorescence and ELISA protein quantification in normal intestinal epithelial cells were measured. The cells were treated with 24 μg/mL Protandim. Nrf-2 protein was translocated to the nucleus within 1 hour of treatment, and reached a maximum level at approximately 10 hours. This inducible translocation was reversible: from 12 hours to 24 hours post-treatment, Nrf-2 signal gradually returned to baseline pre-treatment levels. To determine whether Nrf-2 nuclear localization would stimulate the growth of cancer cells, we treated HCT-116 and CaCo-2 cancer cells with varying doses of Protandim. At no point in time or dose was the activation of Nrf-2 by Protandim associated with increased tumor cell viability. These data support the inducible mechanism of action of Protandim.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Limnocoris brauni De Carlo 1966
Creators: name: Peralta-Argomeda, Jorge Luis
name: Rodrigues, Juliana Mourão Dos Santos
name: Huamantinco-Araujo, Ana
name: Moreira, Felipe Ferraz Figueiredo
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Naucoridae
Limnocoris
Limnocoris brauni

description: Limnocoris brauni De Carlo, 1966
 Geographic distribution. Ecuador (Rodrigues & Sites 2021), Peru (De Carlo 1966b), Bolivia (Rodrigues & Sites 2021).
 Distribution in Peru. Ucayali, Huánuco, Junín (Rodrigues & Sites 2021), Cusco (Sites, in litt.).
 Notes. Details about the type locality in Peru were unknown until Rodrigues & Sites (2021) provided the label data. The same authors associated Aguaytía with Loreto department, but it is in Ucayali department.
description: Published as part of Peralta-Argomeda, Jorge Luis, Rodrigues, Juliana Mourão Dos Santos, Huamantinco-Araujo, Ana & Moreira, Felipe Ferraz Figueiredo, 2024, Checklist of the aquatic and semiaquatic bugs (Hemiptera: Heteroptera: Gerromorpha, Leptopodomorpha & Nepomorpha) of Peru, pp. 1-72 in Zootaxa 5467 (1) on page 36, DOI: 10.11646/zootaxa.5467.1.1, http://zenodo.org/record/11613746
effect of Ethylmethylhydroxypyridine succinate (EMS) on brain degeneration in MS
Creators: name: Prakhova, Lidia
name: Ilves, A.G.
name: Kataeva, G.V.
name: Nikiforova, I.G.
name: Savintceva, Z.I.
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Background. Neurodegeneration has proved to be the major reason of disability in multiple sclerosis. Mitochondrial dysfunction results in functional disturbance without structural damage, then leads to disturbance of respiratory chain function and liberates electrons, giving rise to ROS and to axonal degeneration, cell death, and tissue destruction. Axonal impairments are revealed by DTI in reduced FA. However, there are no drugs with proven efficacy, nor non-invasive evaluation methods of drug's impact on CNS. EMS is an antioxidant and antihypoxant with the wide range of PD effects approved in Russia and CIS.
Objective. To investigate EMS effects on neurodegeneration in MS patient’s brain by evaluating the clinical status and objective quantitative characteristics of cortico-spinal tracts.
Methods: 49 MS patients were treated with EMS, and FA CST was assessed.
Results. Compared with 24 healthy volunteers, the patients had significantly lower FA CST. After the treatment, locomotive ability improved as well as FA CST increased, with lasting clinical effect.

Conclusions. Monitoring of FA CST can be used as an objective instrumental criterion of the therapy efficacy aimed at preventing neuro-degeneration in MS. EMS treatment combined with immune-modulating therapy can provide good results in preventing disabilities in MS, but requires further investigations and RCT.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Preventing oxidative reactions during red blood cell storage for transfusion
Creators: name: Roch, Aline
name: Magon, Nicholas J
name: Koury, Mark J
name: Schapira, Marc
name: Imhof, Beat A
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Red blood cell transfusion is life-saving for severely ill and injured patients. However, transfusion can increase mortality due to the prolonged storage time of blood. Previous studies have indicated that red blood cells undergo structural and molecular changes during storage that affect their lifespan and proper function. To determine whether the SAGM storage solution is a sufficient replacement for the native plasma, we characterized markers of aging for blood samples stored in both conditions. We showed that the antioxidant capacity of stored red blood cells decreases over time, and is significantly lower for red blood cells stored in SAGM than stored in plasma. We observed increased oxidation of Peroxiredoxin-2 during storage, with SAGM samples exhibiting significantly higher oxidation than plasma samples. These data suggest that red blood cells are more oxidatively stressed when stored in SAGM than their native environment. In order to identify antioxidants that could be used as new additives to the current storage solution, we are establishing a high-throughput screening on thousands of chemical compounds, as well as a study on plasma antioxidants. These additives should allow improving the quality of blood transfusion and extending the storage time of blood products.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)
Overexpression of Heterogeneous Nuclear Ribonucleoprotein F (HnRNP F) Prevents Oxidative Stress and Kidney Injury in Diabetic Mice
Creators: name: Chan, John S D
name: Zhang, Shao-Ling
Publisher: name: Journal of International Society of Antioxidants in  Nutrition & Health
Year: 2016

description: Objective To investigate whether overexpression of HnRNP F in renal proximal tubular cells (RPTCs) prevents oxidative stress and apoptosis in type 2 diabetic db/db transgenic (Tg) mice and study its underlying mechanism(s) of action.
 Methods Adult male db/m+, db/db and db/db HnRNP F- Tg mice specifically overexpressing HnRNP F in their RPTCs were studied. Oxidative stress in RPTCs was assessed by dihydroethidium (DHE) staining and reactive oxygen species (ROS) generation. Immunstaining, Western blotting and real-time qPCR were employed to assess pro-apoptotic gene expression. Immortalized rat RPTCs were studied in vitro.
 Results Db/db mice exhibited significantly higher DHE staining, ROS, NADPH oxidase activity, Nox4 and pro-apoptotic gene expression and lower CAT activity and CAT expression than db/m+ mice. These changes were reversed in db/db HnRNP F-Tg mice. SIRT 1 and FOXO3 expression were also significantly decreased in RPTCs of db/db mice and normalized in db/db HnRNP F-Tg mice. In vitro, HnRNP F stimulates Sirt1 gene expression via HnRNP F-responsive element in the Sirt1 gene promoter.
 Conclusions HnRNP F is protective against oxidative stress and RPTC apoptosis via stimulation of Sirt1 gene expression in diabetes.
description: Journal of International Society of Antioxidants in  Nutrition & Health, Vol 3, No 3 (2016)