cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Laser-induced periodic surface structured electrodes with a 45 % energy saving in electrochemical fuel generation through field localization
Creators: name: Saraj, Chaudry Sajed
name: Singh, Subhash C.
name: Verma, Gopal
name: Rajan, Rahul A
name: Li, Wei
name: Guo, Chunlei
Publisher: name: arXiv
Year: 2021
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Electrochemical oxidation-reduction of radicals is a green and environmentally friendly approach to generating fuels. These reactions, however, suffer from sluggish kinetics due to a low local concentration of radicals around the electrocatalyst. A large electrode potential can enhance the fuel generation efficiency via enhancing the radical concentration around the electrocatalyst sites, but this comes at the cost of electricity. Here, we report about a 45 percent saving in energy to achieve an electrochemical hydrogen generation rate of 10 mA per cm2 through localized electric field-induced enhancement in the reagent concentration (LEFIRC) at laser-induced periodic surface structured (LIPSS) electrodes. The finite element model is used to simulate the spatial distribution of the electric field to understand the effects of LIPSS geometric parameters in field localization. When the LIPSS patterned electrodes are used as substrates to support Pt-C and RuO2 electrocatalysts, the overpotentials for HER and OER are decreased by 40 and 25 percent, respectively. Moreover, the capability of the LIPSS-patterned electrodes to operate at significantly reduced energy is also demonstrated in a range of electrolytes including alkaline, acidic, neutral, and seawater. Importantly, when two LIPSS patterned electrodes were assembled as the anode and cathode into a cell, it requires 330 mVs of lower electric potential with enhanced stability over a similar cell made of pristine electrodes to drive a current density of 10 mA/cm2. This work demonstrates a physical and versatile approach of electrode surface patterning to boost electrocatalytic fuel generation performance and can be applied to any metal and semiconductor catalysts for a range of electrochemical reactions.
description: This paper is accepted for publication in May 2022 issue of Optoelectronic Advances
Sull’infanzia: itinerario di alcuni testi esemplari
Creators: name: Sarsini, Daniela
Publisher: name: Studi sulla Formazione
Year: 2012

description: The essay deals with the images of childhood that have established between eighteenth and nineteenth century, through the reading of some exemplar texts, that have become classics (like Rousseau, Becchi, Cambi, Trisciuzzi, Schérer-Hocquengham, Postman and Savater). The purpose is highlight how the epistemological status of childhood is changed during the last centuries in the european culture.
description: Studi sulla Formazione, Anno XIV, II-2011
CA-SBA-793: Archaeological site record for CA-SBA-793
Creators: name: Kekich, Jessica
Year: 2020
Subjects: subject: Santa Barbara (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/3486/santa-barbara-county
subject: Vandenberg Air Force Base (VAFB)
valueUri: https://core.tdar.org/browse/geographic-keyword/85469/vandenberg-air-force-base-vafb
subject: Vandenberg Space Force Base (VSFB)
valueUri: https://core.tdar.org/browse/geographic-keyword/85584/vandenberg-space-force-base-vsfb
subject: California (State / Territory)
valueUri: https://core.tdar.org/browse/geographic-keyword/1484/california-state-territory

description: This document is the archaeological site record for CA-SBA-793.
Gradient Based Seeded Region Grow method for CT Angiographic Image Segmentation
Creators: name: Rai, G. N. Harikrishna
name: Nair, T. R. Gopalakrishnan
Publisher: name: arXiv
Year: 2010
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Segmentation of medical images using seeded region growing technique is increasingly becoming a popular method because of its ability to involve high-level knowledge of anatomical structures in seed selection process. Region based segmentation of medical images are widely used in varied clinical applications like visualization, bone detection, tumor detection and unsupervised image retrieval in clinical databases. As medical images are mostly fuzzy in nature, segmenting regions based intensity is the most challenging task. In this paper, we discuss about popular seeded region grow methodology used for segmenting anatomical structures in CT Angiography images. We have proposed a gradient based homogeneity criteria to control the region grow process while segmenting CTA images.
description: 6 pages, 8 figures
A Nascent Tidal Dwarf Galaxy Forming within the Northern HI Streamer of M82
Creators: name: Pasha, Imad
name: Lokhorst, Deborah
name: van Dokkum, Pieter G.
name: Chen, Seery
name: Abraham, Roberto
name: Greco, Johnny
name: Danieli, Shany
name: Miller, Tim
name: Lippitt, Erin
name: Polzin, Ava
name: Shen, Zili
name: Keim, Michael A.
name: Liu, Qing
name: Merritt, Allison
name: Zhang, Jielai
Publisher: name: arXiv
Year: 2021
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We identify a $\sim$600 pc-wide region of active star formation located within a tidal streamer of M82 via $Hα$ emission ($F_{Hα}\sim 6.5\times10^{-14}$ erg s$^{-1}$ cm$^{-2}$), using a pathfinder instrument based on the Dragonfly Telephoto Array. The object is kinematically decoupled from the disk of M82 as confirmed via Keck / LRIS spectroscopy, and is spatially and kinematically coincident with an overdensity of HI and molecular hydrogen within the "northern HI streamer" induced by the passage of M81 several hundred Myr ago. From HI data, we estimate that $\sim5\times10^7$ M$_{\odot}$ of gas is present in the specific overdensity coincident with the $Hα$ source. The object's derived metallicity (12+$\log(O/H)\simeq 8.6$), position within a gas-rich tidal feature, and morphology (600 pc diameter with multiple star forming clumps), indicate that it is likely a tidal dwarf galaxy in the earliest stages of formation.
description: Version accepted to ApJL. 9 pages, 4 figures
Galathea genkai Miyake & Baba 1964
Creators: name: Macpherson, Enrique
name: Robainas-Barcia, Aymee
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Galatheidae
Galathea
Galathea genkai

description: Galathea genkai Miyake & Baba, 1964
 Galathea genkai Miyake & Baba, 1964: 208, figs 3, 4 (coast of northern Kyushu, 10 m).— Lewinsohn, 1969: 120, fig. 23 (Red Sea, 20–35 m).— Haig, 1974: 447 (Western Australia).— Baba, 1988: 74 (Sibuyan Sea, Philippines, 68 m).— Davie, 2002: 61 (no record).—Baba et al., 2008: 69 (compilation).— Baba et al., 2009: 111, figs. 90–91 (Taiwan).— Poore et al., 2011: 332, pl. 10G (color photo, Taiwan).
 Material examined. South China Sea. Macclesfield Bank, Stn 24, 15°26'30"N, 114°14'E, 24–63 m, May 1892: 1 M 4.3 mm (NHMUK).
Madagascar. ATIMO VATAE, Stn CP3520, 24°51.2'S, 47°28.2'E, 80–86 m, 30 April 2010: 1 M 5.4 mm (MNHN-IU-2013-8433).—Stn DW3532, 24°39.4'S, 47°31.7'E, 86–87 m, 2 May 2010: 1 F 5.5 mm (MNHN-IU- 2013-8432).—Stn DW3605, 24°54.5'S, 44°51.0'E, 56–57 m, 13 May 2010: 1 ov. F 5.5 mm (MNHN-IU-2013- 8435).—Stn DW3606, 25°48.4'S, 44°51.1'E, 44–46 m, 13 May 2010: 1 ov. F 5.6 mm (MNHN-IU-2013-8431).
 Remarks. The species is characterized by the scale-like ridges on the carapace and the absence of epigastric spines. The molecular analyses have shown the existence of a complex of species morphologically differentiated by the shape of the rostrum and the length of the walking legs. We have found three different species: G. genkai Miyake & Baba, 1964, G. gladiola n. sp. from Vanuatu, New Caledonia and Chesterfield Islands, and G. m a c h a e r a n. sp. from the Solomon, Wallis and Futuna Islands (see Remarks of G. machaera).
 Distribution. Japan, northern Kyushu, Philippines, Sibuyan Sea, Taiwan, South China Sea (Macclesfield Bank), Western Australia, Red Sea, Madagascar; 10– 87 m.
description: Published as part of Macpherson, Enrique & Robainas-Barcia, Aymee, 2015, Species of the genus Galathea Fabricius, 1793 (Crustacea, Decapoda, Galatheidae) from the Indian and Pacific Oceans, with descriptions of 92 new species, pp. 1-335 in Zootaxa 3913 (1) on page 126, DOI: 10.11646/zootaxa.3913.1.1, http://zenodo.org/record/239230
La investigación acción partecipativa entre formatión y desarrollo
Creators: name: Del Gobbo, Giovanna
Publisher: name: Studi sulla Formazione
Year: 2010

description: Facing up to the theme of the relationship between methodologies of research and methodologies of formation for sustaining the endogenous development, imposes the reference at two interpretative dimensions, the research of unit and the research of the relationship.  The necessity to start from the relationship and not from the parts and the demand of unit in comparison to a fragmentation, often disguised as the specialization and from the necessity to deep, become imperatives of education and research. It doesn’t deal only with reconstructing unit and tracking the relationship through a ermeneutic process, but it treats rather to individualize and work with methodologies that found their progress upon the search of the relationship and the unit. That means also maturing methodological choices that can produce new knowledges and therefore becoming vehicle of change and innovation. In such context the reference introduced in the contribution is the participatory action research.
description: Studi sulla Formazione, Anno XII, I/II-2009
Efficient use of bioconductor in the cloud
Creators: name: Nitesh Turaga
Publisher: name: F1000 Research Limited
Year: 2021

description: Use Bioconductor on the cloud more efficiently with fully pre-configured docker images and install pre-built Bioconductor binary packages rapidly on these docker images.

 Docker images are available at https://hub.docker.com/r/bioconductor/bioconductor_docker.

 Help on how to use the docker images at http://bioconductor.org/help/docker/
CA-SBA-784: Archaeological site record for CA-SBA-784
Creators: name: Kekich, Jessica
Year: 1985
Subjects: subject: Santa Barbara (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/3486/santa-barbara-county
subject: Vandenberg Air Force Base (VAFB)
valueUri: https://core.tdar.org/browse/geographic-keyword/85469/vandenberg-air-force-base-vafb
subject: Vandenberg Space Force Base (VSFB)
valueUri: https://core.tdar.org/browse/geographic-keyword/85584/vandenberg-space-force-base-vsfb
subject: California (State / Territory)
valueUri: https://core.tdar.org/browse/geographic-keyword/1484/california-state-territory

description: This document is the archaeological site record for CA-SBA-784.
Primer registro de la especie exótica Adalia bipunctata (Linnaeus 1758) (Coleoptera: Coccinellidae) en el departamento del Cusco, Perú
Creators: name: Navarrete, Abdhiel Arnaldo Bustamante
name: Oroz-Ramos, Anahi
Publisher: name: figshare
Year: 2021
Subjects: subject: Zoology
subject: FOS: Biological sciences
subject: 60899 Zoology not elsewhere classified

description: Se presenta el primer registro, para el departamento del Cusco, y el segundo para el Perú, de la especie exótica Adalia bipunctata (Linnaeus 1758). La especie de origen paleártico, y con una amplia distribución, es un predador polífago con un amplio rango de presas, principalmente áfidos y psyllidos, que fue introducida a Chile a mediados del siglo pasado, donde se estableció, y desde donde amplía gradualmente su distribución al subcontinente.
The first record is presented, for the department of Cusco, and the second for Peru, of the exotic species Adalia bipunctata Linnaeus 1758. The species of Palearctic origin, and with a wide distribution, is a polyphagous predator with a wide range of prey, mainly aphids and psyllids, which was introduced to Chile in the middle of the last century, where it was established, and from where it gradually expands its distribution to the subcontinent.
Women’s and femmes’ erotic strategies in Caribbean narrative
Creators: name: Guzzardo Tamargo, Isabel Giovanna
Publisher: name: No Publisher Supplied
Year: 2023

description: In Caribbean culture, marronage has served as a historical model of freedom and, specifically, of national liberation. This dissertation looks at how twenty-first century Caribbean cultural production by queer writers and artists that return to Maroon communities, as a historical and mythic space, to locate, instead, political strategies of entanglement and negotiation. As a group that has always needed to create their own forms of community within a heteronormative world, queer artists find affinities with Maroon communities’ form of rebellion that occurs within, against, and parallel to plantations and, more generally, to systems of power. The literary Maroons that I study practice what I call “erotic marronage:” an erotic and queer practice where women and femmes of color experience pleasure, even as they strategically entangle with misogynoir, colonial, and anti-Black structures. Drawing on Caribbean Queer Theory, Black Feminist thought, and Decolonial Theory, I consider the history of slavery and marronage and its continued influence on power dynamics in “postcolonial” sexuality.
A SCORING MODEL FOR RISK CHARACTERISATION AND SETTING PRIORITIES IN VETERINARY PUBLIC HEALTH
Creators: name: SCALI, FEDERICO
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: A model for prioritization and risk characterization was developed for diseases of interest in veterinary public health. This model was called scorecard and focused on zoonosis and food safety at regional level. The scorecard was part of a shared initiative between Lombardy regional government and the Department of Veterinary Science and Public Health (University of Milan) aimed to improve veterinary regional services. A previous model (DISCONTOOLS) was used as starting point to develop the new one. Formalized Consensus Process approach involving academics and veterinary officers was used to develop the scorecard model. Furthermore, a guide and a form were settled in order lead the scoring process. Formalized Consensus Process is a five-step procedure which includes a systematic review of literature, an assessment of issues, initial proposals, a discussion and improvement of proposals and, finally, a validation of operational recommendations. The final scorecard model has a maximum theoretical score of 1,000; it includes several areas of interest, with different categories and coefficient of importance. The following areas were identified: relevance of the disease, socio-economic impact, impact on public health, impact on trade, impact on animal welfare, control tools. Scorecards were filled following available data, literature and expert opinions. From an initial list of 38 disease, 23 were scored. Among bovine diseases, mastitis (S. aureus) showed the highest score; among small ruminants Query fever was the highest, among swine diseases the highest was salmonellosis, while among other animal diseases toxoplasmosis had the highest score. This approach is conceived to aid professionals in risk prioritization, decision-making and to improve disease control systems at a regional level. It also allows to perform risk characterization in different backgrounds and to identify lacks of data in specific areas of interest for the diseases considered.
CA-SBA-783: Archaeological site record for CA-SBA-783
Creators: name: Kekich, Jessica
Year: 2002
Subjects: subject: Santa Barbara (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/3486/santa-barbara-county
subject: Vandenberg Air Force Base (VAFB)
valueUri: https://core.tdar.org/browse/geographic-keyword/85469/vandenberg-air-force-base-vafb
subject: Vandenberg Space Force Base (VSFB)
valueUri: https://core.tdar.org/browse/geographic-keyword/85584/vandenberg-space-force-base-vsfb
subject: California (State / Territory)
valueUri: https://core.tdar.org/browse/geographic-keyword/1484/california-state-territory

description: This document is the archaeological site record for CA-SBA-783.
Additional file 1 of Revolutionizing Chinese medicine granule placebo with a machine learning four-color model
Creators: name: Teng, Tingting
name: Zhang, Jingze
name: Miao, Peiqi
name: Liang, Lipeng
name: Song, Xinbo
name: Liu, Dailin
name: Zhang, Junhua
Publisher: name: figshare
Year: 2025
Subjects: subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences

description: Supplementary material 1.
CA-SBA-778: Archaeological site record for CA-SBA-778
Creators: name: Kekich, Jessica
Year: 1971
Subjects: subject: Santa Barbara (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/3486/santa-barbara-county
subject: Vandenberg Air Force Base (VAFB)
valueUri: https://core.tdar.org/browse/geographic-keyword/85469/vandenberg-air-force-base-vafb
subject: Vandenberg Space Force Base (VSFB)
valueUri: https://core.tdar.org/browse/geographic-keyword/85584/vandenberg-space-force-base-vsfb
subject: California (State / Territory)
valueUri: https://core.tdar.org/browse/geographic-keyword/1484/california-state-territory

description: This document is the archaeological site record for CA-SBA-778.
Nota biobibliográfica + poética + creaciones («Bica», «Imberbe 1», «Teoría monárquica», «Haiku», «Lorquiana» y «Vocabulario 3») + cuestionario (Victoria Pineda)
Creators: name: Campal, José Luis
Publisher: name: Università degli Studi di Milano
Year: 2014

description: Nota biobibliográfica + poética + creaciones («Bica», «Imberbe 1», «Teoría monárquica», «Haiku», «Lorquiana» y «Vocabulario 3») + cuestionario (Victoria Pineda)
description: Tintas: Quaderni di Letterature iberiche e iberoamericane, Experimental (ed. y coord. de Raúl Díaz Rosales)
Analysis of a Tau Neutrino Origin for the Near-Horizon Air Shower Events Observed by the Fourth Flight of the Antarctic Impulsive Transient Antenna (ANITA)
Creators: name: Prechelt, R.
name: Wissel, S. A.
name: Romero-Wolf, A.
name: Burch, C.
name: Gorham, P. W.
name: Allison, P.
name: Alvarez-Muñiz, J.
name: Banerjee, O.
name: Batten, L.
name: Beatty, J. J.
name: Belov, K.
name: Besson, D. Z.
name: Binns, W. R.
name: Bugaev, V.
name: Cao, P.
name: Carvalho, W.
name: Chen, C. H.
name: Chen, P.
name: Chen, Y.
name: Clem, J. M.
name: Connolly, A.
name: Cremonesi, L.
name: Dailey, B.
name: Deaconu, C.
name: Dowkontt, P. F.
name: Fox, B. D.
name: Gordon, J. W. H.
name: Hast, C.
name: Hill, B.
name: Hsu, S. Y.
name: Huang, J. J.
name: Hughes, K.
name: Hupe, R.
name: Israel, M. H.
name: Liewer, K. M.
name: Liu, T. C.
name: Ludwig, A. B.
name: Macchiarulo, L.
name: Matsuno, S.
name: McBride, K.
name: Miki, C.
name: Mulrey, K.
name: Nam, J.
name: Naudet, C.
name: Nichol, R. J.
name: Novikov, A.
name: Oberla, E.
name: Prohira, S.
name: Rauch, B. F.
name: Ripa, J.
name: Roberts, J. M.
name: Rotter, B.
name: Russell, J. W.
name: Saltzberg, D.
name: Seckel, D.
name: Schoorlemmer, H.
name: Shiao, J.
name: Stafford, S.
name: Stockham, J.
name: Stockham, M.
name: Strutt, B.
name: Sutherland, M. S.
name: Varner, G. S.
name: Vieregg, A. G.
name: Wang, N.
name: Wang, S. H.
name: Zas, E.
name: Zeolla, A.
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We study in detail the sensitivity of the Antarctic Impulsive Transient Antenna (ANITA) to possible $ν_τ$ point source fluxes detected via $τ$-lepton-induced air showers. This investigation is framed around the observation of four upward-going extensive air shower events very close to the horizon seen in ANITA-IV. We find that these four upgoing events are not observationally inconsistent with $τ$-induced EASs from Earth-skimming $ν_τ$, both in their spectral properties as well as in their observed locations on the sky. These four events, as well as the overall diffuse and point source exposure to Earth-skimming $ν_τ$, are also compared against published ultrahigh-energy neutrino limits from the Pierre Auger Observatory. While none of these four events occurred at sky locations simultaneously visible by Auger, the implied fluence necessary for ANITA to observe these events is in strong tension with limits set by Auger across a wide range of energies and is additionally in tension with ANITA's Askaryan in-ice neutrino channel above $10^{19}$ eV. We conclude by discussing some of the technical challenges with simulating and analyzing these near horizon events and the potential for future observatories to observe similar events.
description: 19 pages, 22 figures, will be published in Physical Review D (PRD)
Strangeness Production at low Q^2 in Deep-Inelastic ep Scattering at HERA
Creators: name: H1 Collaboration
Publisher: name: arXiv
Year: 2008
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The production of neutral strange hadrons is investigated using deep-inelastic scattering events measured with the H1 detector at HERA. The measurements are made in the phase space defined by the negative four-momentum transfer squared of the photon 2 < Q^2 < 100 GeV^2 and the inelasticity 0.1 < y < 0.6. The K_s and Lambda production cross sections and their ratios are determined. K_s production is compared to the production of charged particles in the same region of phase space. The Lambda - anti-Lambda asymmetry is also measured and found to be consistent with zero. Predictions of leading order Monte Carlo programs are compared to the data.
description: 35 pages, revised version, accepted by EPJC
Project Conceptualisation in Ecological Project Management.pdf
Creators: name: Ussenaliyeva, Aizhan
Publisher: name: figshare
Year: 2022
Subjects: subject: 40301 Basin Analysis
subject: FOS: Earth and related environmental sciences
subject: 40501 Biological Oceanography
subject: Atmospheric Sciences

description: My journal contribution describing the basic principles of the ecological project conceptualisation.
Additional file 2 of Revolutionizing Chinese medicine granule placebo with a machine learning four-color model
Creators: name: Teng, Tingting
name: Zhang, Jingze
name: Miao, Peiqi
name: Liang, Lipeng
name: Song, Xinbo
name: Liu, Dailin
name: Zhang, Junhua
Publisher: name: figshare
Year: 2025
Subjects: subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences

description: Supplementary material 2.
Efficient electrospray deposition of functional payloads
Creators: name: Park, Sarah He Yeun
Publisher: name: No Publisher Supplied
Year: 2023

description: Electrospray ionization (ESI) was first reported in detail by John Zeleny, when he demonstrated that a high voltage applied to the end of a capillary containing a volatile fluid resulted in the emergence of charged droplets at the end of the nozzle. More recently, electrospray deposition (ESD), a related technique to ESI where the droplets carry a non-volatile load, was developed as a promising technique for depositing micro- and nano-scale droplets and particles with high quality and uniformity. A related technique, electrostatic spray, which adds an air jet to propel a larger volume of fluid, was especially attractive for agricultural industries to spray pesticides and the automotive industry for painting. Returning to ESD, by applying a high electric field onto a dilute solution, monodispersed charged droplets emerge from the needle tip and move toward a grounded target. Based on certain parameters—such as solvent properties, dielectric constant, and the applied voltage to name a few—ESD can exist in several mode of spraying. These modes are differentiated by the shape at the end of the capillary and the dispersion of droplets. More notably, the cone-jet mode maintains a cone at the tip of the nozzle which is stabilized by competing interactions between surface tension and coulombic forces. Although many studies have been conducted using this regime of spray to coat conformally, research has been limited applying this technique onto targets smaller than the characteristic spray plume. Deposition efficiencies spraying these smaller targets were reported to be lower than 30%. Further, those who were successful in spraying materials while maintaining functionality typically sprayed in an jetting mode as opposed to the stable Taylor-cone jet. Studies using ESD for more structurally sensitive materials, such as DNA and protein, have reported causing damage post-processing. This is likely due to the shear stress associated at the Taylor-cone, causing a viscous drag force onto the material. The mechanical properties of blended matrices or emulsions can be explored to protect the functional payloads from damage during the ESD process. Thus, the objective of our research is to use this process to our advantage and apply it more broadly to deliver materials while still maintaining functionality and efficiency.
Development of BioPROTACs Targeting Viral Proteins of Two RNA Viruses
Creators: name: Pham, Jordan Alexander Grant
Publisher: name: Université d'Ottawa | University of Ottawa
Year: 2024
Subjects: PROTAC
SARS-CoV-2
Hepatitis C
bioPROTAC
Virus
Antiviral

description: Over the last two decades, PROTACs have rapidly developed as a novel class of pharmaceutical agents, owing to their potential for targeting proteins that are considered a challenge with traditional small molecules. This namely consists of non-enzymatic proteins previously considered “undruggable”. Significant efforts have gone into developing PROTACs against oncology targets for cancer therapy, with some currently in Phase III clinical trials today. However, very few studies have explored the use of this new technology in the context of antiviral drug discovery. Here, we will describe our efforts to generate two biological PROTACs (bioPROTACs) targeting two different RNA viruses that have garnered particular interest at points within the last decade. We first sought to develop a fusion bioPROTAC that targets the structural proteins of SARS-CoV-2. This bioPROTAC was designed from a monomer of the Spike protein. We proposed this could incorporate itself within the trimer of the Spike protein, enabling ubiquitination and degradation of the Spike timer. We demonstrated this bioPROTAC efficiently degrades WT Spike protein, as well as other SARS-CoV-2 structural proteins in a 26S proteasome-dependent manner. Treatment with this bioPROTAC also reduces the production of SARS-CoV-2 pseudotyped viruses through its degradation of the Spike protein. We propose that this bioPROTAC has potential as an antiviral therapeutic and is likely to reduce the propagation of SARS-CoV-2 in the context of a viral infection. We also aimed to generate a hybrid bioPROTAC for targeting the non-structural proteins of the Hepatitis C (HCV) replication complex. These proteins are traditionally difficult to target due to their tendency to shield themselves from the innate immune system by completing their replication within double membrane vesicles. We used site-directed mutagenesis to site-specifically incorporate the non-canonical amino acid p-azido-L¬-phenylalanine (AzF) to act as a bioorthogonal handle for the covalent addition of a VHL ligand, a traditional ligand in PROTAC development. We showed this hybrid bioPROTAC construct is not only capable of associating with the E3 ubiquitin ligase complex to form a ternary complex, but that the presence of this bioPROTAC reduces the activity of the HCV replication complex and in turn, decreases viral propagation of the JFH1T-2a strain of HCV. Notably, this bioPROTAC demonstrated a DC50 far lower than a previously-studied traditional PROTAC targeting the HCV NS3 protease. Collectively, the work described here sets a foundation for understanding how a bioPROTAC approach to specifically target and degrade viral proteins may act as a viable alternative for the future design and development of antiviral therapeutics.
Climate Change and Arctic Shipping Futures: Community Perspectives on the State of Shipping and Emergency Preparedness in Canada’s Northwest Passage
Creators: name: Yaremko, Jeffrey
Publisher: name: Université d'Ottawa | University of Ottawa
Year: 2024
Subjects: Arctic
Shipping Accidents
Marine Disasters
Emergency Preparedness
National Security
Community-based research
Coastal community perspectives
Climate Change Adaptations

description: Shipping trends in the Canadian Arctic are projected to continue along a rising trajectory due to a warming climate, loss in sea ice extent, and growing economic interests in the region. This is resulting in global interest in the region and potential for Arctic shipping routes, notably the Northwest Passage (NWP). As Arctic shipping traffic continues to rapidly grow in Canada, questions arise about the preparedness of both coastal communities and government in the event of a shipping accident, or a worst-case scenario shipping disaster. This thesis aims to integrate the perspectives of residents from Pond Inlet, Nunavut, a coastal community that sits along the entranceway/exit of the NWP and is at-risk of experiencing a shipping accident in the region. A review of literature and relevant grey literature (i.e. acts, agreements, reports) was undertaken to ground the study in current research and policy. A survey with a quantitative and qualitative approach was implemented to document the perspectives of Pond Inlet residents, verifying and identifying changes in shipping patterns in the region and exploring shipping futures around the community. This also entailed acquiring an understanding of how residents perceived shipping accidents, worst-case scenarios, and emergency preparedness for their community and the region. This study contributes to current understandings and research on the state of Arctic shipping and emergency preparedness from the perspectives of coastal communities in the region.
Essential model parameters for nonreciprocal magnons in multisublattice systems
Creators: name: Hayami, Satoru
name: Matsumoto, Takuya
Publisher: name: arXiv
Year: 2021
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We theoretically investigate the microscopic conditions for emergent nonreciprocal magnons toward unified understanding on the basis of a microscopic model analysis. We show that the products of the Bogoliubov Hamiltonian obtained within the linear spin wave approximation is enough to obtain the momentum-space functional form and the key ingredients in the nonreciprocal magnon dispersions in an analytical way even without solving the eigenvalue problems. We find that the odd order of an effective antisymmetric Dzyaloshinskii-Moriya interaction and/or the even order of an effective symmetric anisotropic interaction in the spin rotated frame can be a source of the antisymmetric dispersions. We present possible kinetic paths of magnons contributing to the antisymmetric dispersions in the one- to four-sublattice systems with the general exchange interactions. We also test the formula for both ferromagnetic and antiferromagnetic orderings in the absence of spatial inversion symmetry.
description: 15 pages 8 figures
Influence of Sustainable Concrete Mix Designs on Costs and Global Warming Potential
Creators: name: Abu Shammeh, Sami
Publisher: name: Université d'Ottawa | University of Ottawa
Year: 2024
Subjects: Low Cement Concrete
Recycled Concrete Aggregates
Cost
Global Warming Potential

description: Pressure continues to increase globally within governments and various industries such as manufacturing and construction to embrace eco-friendly practices aiming to diminish CO2 emissions; therefore, researchers worldwide started developing innovative eco-friendly materials such as concrete with supplementary cementitious materials (SCM); low cement concrete (LCC) using advanced mix design techniques such as PPM’s and/or MP’s; and recycled concrete aggregates (RCA), etc. These materials are at different stages of research for their use in structural application and have proven to have the same and/or superior performance to conventional concrete throughout the research completed in the past few years, but the concrete industry currently has a lack of knowledge on cost for the use of these materials which represents a current gap in the literature that needs further research. Since the construction industry’s main constraint nowadays on all projects is the cost associated with the work, and since the use of innovative eco-friendly materials in infrastructure construction is becoming a requirement, the cost associated with these materials needs to be studied further. This study aims to evaluate the upfront cost impact and global warming potential of different sustainable concrete mixtures such as use of SCM’s, PPM’s, MP’s, and RCA’s in concrete mixtures. The direct cost of each of these concrete mixtures may vary due to a variety of factors such as market conditions, material availability, region, and supply/demand; therefore, the purpose of this study is to review the relative difference of these mixtures under same conditions. Trends in the construction industry show that due to resource constraints and new sustainability requirements, conventional concrete mixtures will become obsolete and will need to be replaced by innovative eco-friendly mixtures. Results of this study indicate that the use of PPM’s, MP’s and RCA’s either individually or in combination are not just able to reduce the cost of concrete mixtures but also reduce the global warming potential (GWP). Two new parameters were established as part of this work, first was to simultaneously assess cost and eco-efficiency using a “carbon cost intensity” (CCI) factor; second was to simultaneously assess concrete’s performance, economic impact, and environmental impact using a “Integrated Strength Cost Eco-Efficiency” (I-SCEE) coefficient.
Follow-up Observations of the Second and Third Known Pulsating Hot DQ White Dwarfs
Creators: name: Dufour, P.
name: Green, E. M.
name: Fontaine, G.
name: Brassard, P.
name: Francoeur, M.
name: Latour, M.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present follow-up time-series photometric observations that confirm and extend the results of the significant discovery made by Barlow et al.(2008) that the Hot DQ white dwarfs SDSS J220029.08-074121.5 and SDSS J234843.30-094245.3 are luminosity variable. These are the second and third known members of a new class of pulsating white dwarfs, after the prototype SDSS J142625.71+575218.3 (Montgomery et al. 2008). We find that the light curve of SDSS J220029.08-074121.5 is dominated by an oscillation at 654.397+-0.056 s, and that the light pulse folded on that period is highly nonlinear due to the presence of the first and second harmonic of the main pulsation. We also present evidence for the possible detection of two additional pulsation modes with low amplitudes and periods of 577.576+-0.226 s and 254.732+-0.048 s in that star. Likewise, we find that the light curve of SDSS J234843.30-094245.3 is dominated by a pulsation with a period of 1044.168+-0.012 s, but with no sign of harmonic components. A new oscillation, with a low amplitude and a period of 416.919+-0.004 s, is also probably detected in that second star. We argue, on the basis of the very different folded pulse shapes, that SDSS J220029.08-074121.5 is likely magnetic, while SDSS J234843.30-094245.3 is probably not.
description: 12 pages, 19 figures, accepted for publication in ApJ
Solar neutrino results from Borexino and main future perspectives
Creators: name: Pallavicini, M.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Borexino is a solar neutrino experiment running at the Laboratori Nazionali del Gran Sasso, Italy. The radioactive background levels in the liquid scintillator target meet or even exceed design goals, opening unanticipated opportunities. The main results, so far, are the measurement of the $^7$Be solar neutrino flux (the first ever done) and the measurement of the $^8$B neutrino flux performed with electron energy threshold of 2.8 MeV. The short and medium term perspectives are summarized in the conclusions.
description: Proceedings of the RICAP 2009 workshop
Ricordando la Shoah. Nota pedagogica
Creators: name: Fratini, Tommaso
Publisher: name: Studi sulla Formazione
Year: 2014

description: This paper develops some considerations on mourning and memory of the Shoah, for the occasion of the Holocaust Memorial Day. It is argued that an educational model for awareness in confronting the collective drama of the Shoah could fully integrate the memory with an analysis of the social processes that still create the development and spread of racism in society, with particular attention to the symbolic meaning evocative of minorities in the processes of social integration.
description: Studi sulla Formazione, Anno XVI, II-2013
title: Humans of AI3SD: Olexandr Isayev
Creators: name: Pauli, Michelle
name: Isayev, Olexandr
Publisher: name: University of Southampton
Year: 2022
Subjects: AI3SD, Interview

description: In this Humans of AI4SD interview he discusses developing the next generation of computational chemistry methods, the challenges and rewards of multidisciplinary projects, how AI is changing science and the importance of cultural change for open science.
Skyrmion crystal and spiral phases in centrosymmetric bilayer magnets with staggered Dzyaloshinskii-Moriya interaction
Creators: name: Hayami, Satoru
Publisher: name: arXiv
Year: 2021
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We theoretically study a stabilization mechanism of the skyrmion crystal in centrosymmetric magnets with a bilayer structure. We show that the interplay between a layer-dependent staggered Dzyaloshinskii-Moriya interaction that arises from the absence of local inversion symmetry and the interlayer exchange interaction gives rise to a plethora of multiple-$Q$ states including the skyrmion crystal with a quantized topological number. By performing the simulated annealing for the bilayer triangular-lattice model under an external magnetic field, we demonstrate that the skyrmion forms the triangular-shaped crystals with different helicities in each layer owing to the staggered Dzyaloshinskii-Moriya interaction. Although the relative positions of the skyrmion core in each layer are different depending on the sign of the interlayer exchange interactions, the skyrmion crystal phases robustly appear under both ferromagnetic and antiferromagnetic interlayer interactions. We also find another two triple-$Q$ states with a uniform scalar chirality but without a quantized topological number in the low- and high-field regions. Especially, the low-field triple-$Q$ state exhibits the opposite sign of the scalar chirality to the skyrmion crystal, which are not found in the single-layer system. Our results indicate that the lack of local inversion symmetry in the lattice structure is another key ingredient to induce topological spin textures in centrosymmetric magnets.
description: 14 pages, 10 figures
Additional file 3 of Revolutionizing Chinese medicine granule placebo with a machine learning four-color model
Creators: name: Teng, Tingting
name: Zhang, Jingze
name: Miao, Peiqi
name: Liang, Lipeng
name: Song, Xinbo
name: Liu, Dailin
name: Zhang, Junhua
Publisher: name: figshare
Year: 2025
Subjects: subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences

description: Supplementary material 3.
Short-Term Warm-Water Immersion as a Heat Acclimation Strategy to Enhance Heat Dissipation in Older Adults: An Exploratory Study
Creators: name: Janetos, Kristina-Marie
Publisher: name: Université d'Ottawa | University of Ottawa
Year: 2024
Subjects: Aging
climate change
heat stress
heat wave
passive heat acclimation
thermoregulation

description: Heat acclimation mediated by repeated daily bouts of exercise in hot environments, can induce marked improvements in physiological and thermoregulatory function. However, recurrent bouts of strenuous exercise in the heat may be untenable for many heat-vulnerable older adults. While heat acclimation induced via warm-water immersion has been shown to provide near comparable improvements in thermoregulatory function in young adults, it remains unclear if a similar response would be observed in older adults. Warm-water immersion would represent a safe and practical approach to improve heat tolerance for many older populations. Thus, the present study was directed at evaluating the effectiveness of a seven-day passive warm-water (~40°C) immersion protocol (60-min at a fixed core temperature of ~38.5°C) in enhancing whole-body heat loss (WBHL) in twelve habitually active older males (mean (SD): 69 (6) years; peak aerobic power [V̇O2peak]: 32.7 (3.8) mL·kg-1·min-1). Before (Day 0) and after (Day 8) a 7-day heat acclimation protocol, whole-body (dry and evaporative) heat exchange was measured using a direct air calorimeter during an incremental intermittent exercise test. The exercise heat-stress test consisted of three, 30-min bouts of cycling performed at increasing fixed rates of metabolic heat production (150 (Low), 200 (Moderate), and 250 W·m-2 (Vigorous); equivalent to 30 (5), 42 (7) and 51 (9) % of their pre-determined V̇O2peak), each separated by 15-min of seated recovery, in a hot-dry environment (40°C, ~13% relative humidity). WHBL increased by 29 W·m-2 [95% Confidence Interval: 19, 39] at the highest metabolic heat load (P<0.01) on Day 8 relative to Day 0. This was paralleled by a reduction in body heat storage (-82 [-116, -48] kJ) and rectal temperature (-0.3 [-0.5, -0.2] °C; both P<0.01), as well as a reduction in cardiovascular strain indexed by a decrease in heart rate (-12 [-7, -17] beats·min-1; P<0.01). Altogether, we showed that a short-term passive warm-water immersion protocol is associated with marked improvements in the body’s physiological capacity to dissipate heat in older adults. The increase in heat loss capacity may help safeguard older populations when exposed to hot environments or performing physical activity by mitigating potentially dangerous increases in body temperatures.
Signatures of the nematic ordering transitions in the thermal conductivity of d-wave superconductors
Creators: name: Fritz, Lars
name: Sachdev, Subir
Publisher: name: arXiv
Year: 2009
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We study experimental signatures of the Ising nematic quantum phase transition in d-wave superconductors, associated with the change of lattice symmetry from tetragonal to orthorhombic in the superconducting state. The characteristic feature of this transition is that the ratio between the Fermi velocity $v_F$ and gap velocity $v_Δ$ flows to a maximally anisotropic fixed point, i.e. the renormalization group fixed point is situated at (v_Δ/v_F)^*=0$. Our main point is that the logarithmic approach to this fixed point has visible signatures in the thermal transport. The analysis of the quasiparticle contribution to the thermal transport is carried out in the framework of a kinetic approach, which shows that the thermal conductivity is enhanced near the nematic critical point. Another aspect of our study is the interplay of dilute disorder and electronic interactions in the measured thermal transport coefficients.
description: 15 pages, 4 figures. revised version as accepted by Phys. Rev. B, added a figure and expanded discussion
A comparison of three techniques for the determination of deformation properties of rock
Creators: name: Norrish, Norman Ian
Publisher: name: University of British Columbia
Year: 2010

description: Laboratory and in situ testing programmes to determine the deformation behaviour of three rock types have provided an opportunity for a comparison of three testing techniques. To aid future standardization, procedures and equipment for the laboratory testing, Goodman Jack testing and plate loading tests are presented in detail. Laboratory tests and plate loading tests show that the gneiss and schist rock types are well differentiated on the basis of deformation modulus. The ratio of average modulus for gneiss to schist is 2.0 from the laboratory testing and 5.6 for the plate loading tests. The Goodman Jack modulus values are similar for all rock types, the ratio of gneiss to schist being 1.3. Similarly the laboratory and plate loading tests show a wide range of values while the jack tests exhibit a very narrow range. The modulus results for the schist conform to the anticipated scale effect while the gneiss tests do not. It is concluded that the partial correlation between the three testing techniques reflects the need to quantify important factors such as rock quality and in situ stresses and to incorporate these factors into valid interpretive formulae. Anisotropy investigations for the laboratory and plate loading tests are consistent. The schist is approximately twice as rigid loaded parallel to the foliation than when loaded perpendicular to it. Anisotropy investigations with the Goodman Jack are qualitative only without very detailed geologic information at the test locations. Permanent deformations of the rock are consistent for the three testing methods and reflect the volume of rock influenced as well as the rock quality at the test location.
Non-linear electrodynamics non-minimally coupled to gravity:symmetric-hyperbolicity and causal structure
Creators: name: Goulart, Érico
name: Bergliaffa, Santiago Esteban Perez
Publisher: name: arXiv
Year: 2021
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: It is shown here that symmetric hyperbolicity, which guarantees well-posedness, leads to a set of two inequalities for matrices whose elements are determined by a given theory. As a part of the calculation, carried out in a mostly-covariant formalism, the general form for the symmetrizer, valid for a general Lagrangian theory, was obtained. When applied to nonlinear electromagnetism linearly coupled to curvature, the inequalities lead to strong constraints on the relevant quantities, which were illustrated with applications to particular cases. The examples show that non-linearity leads to constraints on the field intensities, and non-minimal coupling imposes restrictions on quantities associated to curvature.
description: 28 pages, submitted for publication on November 24, 2021
Fictitious Magnetic Resonance by Quasi-Electrostatic Field
Creators: name: Kobayashi, Jun
name: Shibata, Kosuke
name: Aoki, Takatoshi
name: Kumakura, Mitsutaka
name: Takahashi, Yoshiro
Publisher: name: arXiv
Year: 2008
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: We propose a new kind of spin manipulation method using a {\it fictitious} magnetic field generated by a quasi-electrostatic field. The method can be applicable to every atom with electron spins and has distinct advantages of small photon scattering rate and local addressability. By using a $\rm{CO_2}$ laser as a quasi-electrostatic field, we have experimentally demonstrated the proposed method by observing the Rabi-oscillation of the ground state hyperfine spin F=1 of the cold $\rm{^{87}Rb}$ atoms and the Bose-Einstein condensate.
description: 5 pages, 5 figures