cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Mechanism of µ-OR1 and PAR2-mediated ER Ca2+ Release in Acute Lymphoblastic Leukemia (aLL) cells and the Regulation of Downstream Signaling Mediators
Creators: name: Kamran, Hamza
Publisher: name: Cumming School of Medicine
Year: 2022
Subjects: subject: Blood cancers
subject: acute lymphoblastic leukemia
subject: L-asparaginase
subject: Health Sciences--Immunology
subject: Health Sciences--General
subject: Health Sciences--Medicine and Surgery

description: Acute lymphoblastic leukemia (aLL) is a hematologic cancer that accounts for over a quarter of all pediatric cancer deaths. L-asparaginase (L-ASNase) has been routinely utilized as a standard therapeutic option due to its perceived ability to deplete serum asparagine, thus inhibiting protein synthesis in aLL cells. But the precise mechanism behind L-ASNase-induced cell death in aLL cells and L-ASNase resistance remain poorly understood. Thus, our lab utilized genome-wide RNA interface screening to identify two L-ASNase resistance biomarkers, huntingtin-associated protein 1 (HAP1) and opioid receptor mu 1 (µ-OR1). We demonstrated that the synthetic opioid, D,L-methadone, causes aLL apoptosis via µ-OR1-triggered endoplasmic reticulum (ER) calcium (Ca2+) release and decrease in Ca2+ efflux. The mechanism behind µ-OR1-induced ER Ca2+ release remains unexplored, however. Using single-cell imaging, I show that D,L-methadone-induced ER Ca2+ release is blocked by inhibition of the G?i G-protein subunit, but not G??, indicating that the process is dependent on G?i. Activation of adenylyl cyclase (AC) with forskolin or treatment with 8-CPT-cAMP blocks ER Ca2+ release, signifying that D,L-methadone-induced ER Ca2+ release in aLL cells results from G?i-dependent downregulation of AC and cAMP. The 14-22 amide (myr) protein kinase A (PKA) inhibitor alone elicits ER Ca2+ release, and subsequent treatment with D,L- methadone does not cause additional ER Ca2+ release, demonstrating that PKA inhibition is a key process that can bypass the D,L-methadone-µ-OR1-AC-cAMP step. I further demonstrated that L-ASNase mainly evokes ER Ca2+ release in aLL cells through activation of µ-OR1, while activation of another G-protein coupled receptor, protease-activated receptor 2 (PAR2), plays a comparatively minor role. Activation of PAR2 elicits ER Ca2+ release through activation of the G?q G-protein subunit which then stimulates phospholipase C beta 3 (PLC?3), promoting inositol triphosphate (IP3) formation. Furthermore, I showed that protein phosphatase 2B (PP2B) is the phosphatase that works to regulate the phosphorylation state of pSer1105-PLC?3 following µ-OR1 or PAR2 activation. Altogether, my research presents an alternative view to how L-ASNase therapy may be evoking apoptosis in aLL cells.
Работы Левобережной славяно-русской экспедиции
Creators: name: О.В., Сухобоков
name: Орлов, Руслан
name: О. В, Иченская
name: С.П., Юренко
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 430101
subject: Archaeological science

description: Сухобоков О.В, Орлов Р.С., О.В.Иченская, С.П.Юренко Работы Левобережной славяно-русской экспедиции. Археологические открытия 1978 года. - М., 1979. - С.407-409.Works of the Left Bank Slavic-Rus Expedition
New caffeoyl derivatives from Elephantopus scaber
Creators: name: Fu, Lu
name: Pei, Di
name: Yu, Meng
name: Li, Ling-Yu
name: Jia, Hong-Mei
name: Zhang, Hong-Wu
name: Shang, Hai
name: Yu, Shi-Shan
name: Zhang, Tao
name: Zou, Zhong-Mei
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Three new caffeoyl derivatives (1–3), together with two known ones (4–5), were isolated from the whole plant of Elephantopus scaber Linn. The structures of the new compounds were elucidated using detailed spectroscopic analysis. Compound 4 was obtained and its NMR data were given for the first time. All isolates were evaluated for their anti-inflammatory activity against lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production and pro-inflammatory cytokines release in RAW 264.7 cells. Compounds 2–5 showed mild inhibitory activities with IC50 values ranging from 64.78 to 87.21 μM, and 3–4 could inhibit LPS-induced tumor necrosis factor-α (TNF-α) production.
A product representation of pi
Creators: name: Holcombe, S. R.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: This short note delivers, via elementary calculations, a product representation of pi.
description: 4 pages, zeta function, zeta(3), infinite product, pi, Euler 1773
T cell migration requires ion and water influx to regulate actin polymerization
Creators: name: De Boer, Leonard L
name: Vanes, Lesley
name: Melgrati, Serena
name: O'May, Joshua Biggs
name: Hayward, Darryl
name: Driscoll, Paul C
name: Day, Jason
name: Griffiths, Alexander
name: Magueta, Renata
name: Morrell, Alexander
name: MacRae, James I
name: Köchl, Robert
name: Tybulewicz, Victor LJ
Publisher: name: The Francis Crick Institute
Year: 2023
Subjects: classificationCode: Tumour Biology
subject: Tumour Biology
classificationCode: Signalling & Oncogenes
subject: Signalling & Oncogenes
classificationCode: Metabolism
subject: Metabolism
classificationCode: Immunology
subject: Immunology
subject: FOS: Clinical medicine
classificationCode: Infectious Disease
subject: Infectious Disease
classificationCode: Human Biology & Physiology
subject: Human Biology & Physiology
classificationCode: Developmental Biology
subject: Developmental Biology
classificationCode: Computational & Systems Biology
subject: Computational & Systems Biology
classificationCode: Cell Biology
subject: Cell Biology
classificationCode: Biochemistry & Proteomics
subject: Biochemistry & Proteomics
classificationCode: Model organisms
subject: Model organisms

description: Migration of T cells is essential for their ability to mount immune responses. Chemokine-induced T cell migration requires WNK1, a kinase that regulates ion influx into the cell. However, it is not known why ion entry is necessary for T cell movement. Here we show that signaling from the chemokine receptor CCR7 leads to activation of WNK1 and its downstream pathway at the leading edge of migrating CD4+ T cells, resulting in ion influx and water entry by osmosis. We propose that WNK1-induced water entry is required to swell the membrane at the leading edge, generating space into which actin filaments can polymerize, thereby facilitating forward movement of the cell. Given the broad expression of WNK1 pathway proteins, our study suggests that ion and water influx are likely to be essential for migration in many cell types, including leukocytes and metastatic tumor cells.
Toward realizing commercially viable MDI-QKD
Creators: name: Smith, Jordan D
Publisher: name: Science
Year: 2023
Subjects: subject: quantum
subject: cryptography
subject: QKD
subject: MDI-QKD
subject: cybersecurity
subject: communication
subject: Physical Sciences
subject: Mathematics
subject: FOS: Mathematics
subject: Physics--Optics

description: Recent advances in quantum computing have brought the relevance of quantum cryptography to the forefront. Measurement-device-independent quantum key distribution (MDI-QKD) is a leading quantum cryptographic protocol for commercial use due to its superior security and cost-effective architecture, featuring users transmitting quantum states encoded in light to a central photon-measurement node. A main advantage of MDI-QKD, compared to other commercial QKD options, is that an adversary may be in full control of the central hardware, notably the single-photon detectors, and yet the resulting cryptographic key is trustworthy. In this work, an MDI-QKD system architecture is designed, engineered, specified, and partially implemented. Of primary importance and challenge are the feedback-based control systems that maximize gain, minimize quantum bit error rate (QBER), and ensure indistinguishability of the photonic signals from end users. In this work, control systems to minimize noise in the optical signals and maximize the specified indistinguishable polarization state are conceived, modelled, and implemented. The work represents progress toward commercially viable MDI-QKD, and future work will continue toward this objective.
“A horror so deep only ritual can contain it”: The art of dying in the theatre of Sarah Kane
Creators: name: Soncini, Sara
Publisher: name: Università degli  Studi di Milano
Year: 2010
Subjects: Sarah Kane; contemporary theatre; death; embodiedness

description: Death is an overarching presence in Sarah Kane's dramatic universe, peopled by characters charging towards death, and usually encountering it in scenes of Grand Guignol excess and grotesque violence. Death is ambivalently presented as the only escape from the nightmare of living and, at the same time, as that which makes living a nightmare; as the moment of "complete sanity and humanity" in which "everything suddenly connects", and as the ultimate, irrevocable and unredeemable act of self-annihilation. Following Kane's turn towards a more poetic form of drama, in her last two plays this discourse of death is handed over to the words nameless characters or unidentified voices who are likewise engaged in a long, painful quest for selfhood pivoting on the awareness of mortality and the simultaneous dread of and longing for death it engenders.
This essay focuses on the ritual quality of the death scenes and/or narratives that crowd Kane's drama. Throughout her work, dying is never an easy, straightforward business, but rather a long, complicated, and at times frustrating mise en scène which also entails rehearsing a repertory of traditional rituals and, once their shortcomings become apparent, devising and testing new ones. The amount of theatricality involved in the art of dying is foregrounded through a web of intertextual references to other literary and/or dramatic sources; this dialogue ties in with a self-reflexive probing of the theatre's ability to provide a ritual that will be capable of "contain[ing] the horror" by supplying a formal framework to express, embody and experience death collectively.
description: Altre Modernità, No 4 (2010): La morte e i suoi riti nella cultura contemporanea
Harmonic Analysis of Boolean Networks: Determinative Power and Perturbations
Creators: name: Heckel, Reinhard
name: Schober, Steffen
name: Bossert, Martin
Publisher: name: arXiv
Year: 2011
Subjects: subject: Information Theory (cs.IT)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Molecular Networks (q-bio.MN)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Consider a large Boolean network with a feed forward structure. Given a probability distribution on the inputs, can one find, possibly small, collections of input nodes that determine the states of most other nodes in the network? To answer this question, a notion that quantifies the determinative power of an input over the states of the nodes in the network is needed. We argue that the mutual information (MI) between a given subset of the inputs X = {X_1, ..., X_n} of some node i and its associated function f_i(X) quantifies the determinative power of this set of inputs over node i. We compare the determinative power of a set of inputs to the sensitivity to perturbations to these inputs, and find that, maybe surprisingly, an input that has large sensitivity to perturbations does not necessarily have large determinative power. However, for unate functions, which play an important role in genetic regulatory networks, we find a direct relation between MI and sensitivity to perturbations. As an application of our results, we analyze the large-scale regulatory network of Escherichia coli. We identify the most determinative nodes and show that a small subset of those reduces the overall uncertainty of the network state significantly. Furthermore, the network is found to be tolerant to perturbations of its inputs.
Requirements for a New Detector at the South Pole Receiving an Accelerator Neutrino Beam
Creators: name: Tang, Jian
name: Winter, Walter
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: There are recent considerations to increase the photomultiplier density in the IceCube detector array beyond that of DeepCore, which will lead to a lower detection threshold and a huge fiducial mass for the neutrino detection. This initiative is known as "Phased IceCube Next Generation Upgrade" (PINGU). We discuss the possibility to send a neutrino beam from one of the major accelerator laboratories in the Northern hemisphere to such a detector. Such an experiment would be unique in the sense that it would be the only neutrino beam where the baseline crosses the Earth's core. We study the detector requirements for a beta beam, a neutrino factory beam, and a superbeam, where we consider both the cases of small theta_13 and large theta_13, as suggested by the recent T2K and Double Chooz results. We illustrate that a flavor-clean beta beam best suits the requirements of such a detector, in particular, that PINGU may replace a magic baseline detector for small values of theta_13 -- even in the absence of any energy resolution capability. For large theta_13, however, a single-baseline beta beam experiment cannot compete if it is constrained by the CERN-SPS. For a neutrino factory, because of the missing charge identification possibility in the detector, a very good energy resolution is required. If this can be achieved, especially a low energy neutrino factory, which does not suffer from the tau contamination, may be an interesting option for large theta_13. For the superbeam, where we use the LBNE beam as a reference, electron neutrino flavor identification and statistics are two of the main limitations. Finally, we demonstrate that, at least in principle, neutrino factory and superbeam can measure the density of the Earth's core to the sub-percent level for sin^2 2theta_13 larger than 0.01.
description: 34 pages, 15 figures. Minor changes and accepted in JHEP
title: The many faces of drug-induced organizing pneumonia in immunocompromised patients: spectrum of chest HRCT imaging findings.
Creators: name: Di Mico, Luisa
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Drugs / Reactions
subject: Diagnostic procedure
subject: CT
subject: Lung

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To illustrate the spectrum of findings of drug-induced organizing pneumonia (OP) in chest High-Resolution Computed Tomography (HRCT) in immunocompromised patients undergoing...
Upper Tails for Cliques
Creators: name: DeMarco, Bobby
name: Kahn, Jeff
Publisher: name: arXiv
Year: 2011
Subjects: subject: Probability (math.PR)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 60F10, 05C80

description: With $ξ_{k}=ξ_{k}^{n,p}$ the number of copies of $K_k$ in the usual (Erdős-Rényi) random graph $G(n,p)$, $p\geq n^{-2/(k-1)}$ and $η>0$, we show when $k>1$ $$\Pr(ξ_k> (1+η)\E ξ_k) < \exp [-\gO_{η,k} \min\{n^2p^{k-1}\log(1/p), n^kp^{\binom{k}{2}}\}].$$ This is tight up to the value of the constant in the exponent.
description: 25 pages
title: Imaging evaluation of immune-related adverse events in immune-checkpoint inhibitors cancer therapy
Creators: name: Valenti, Giacomo
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Drugs / Reactions
subject: Complications
subject: MR
subject: CT
subject: Oncology

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To describe the radiological features of the immune-related adverse events (irAEs) in cancer immunotherapy by immune-checkpoint inhibitors (ICIs) To correlate toxicities with their clinical characteristics Tounderline the role of Radiologist in the...
title: Peritoneal metastases – role of diagnostic imaging in therapeutic decision-making process
Creators: name: Szadkowska, Małgorzata
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Cancer
subject: Structured reporting
subject: Staging
subject: Diagnostic procedure
subject: MR-Diffusion/Perfusion
subject: MR
subject: CT
subject: Peritoneum
subject: Oncology
subject: Abdomen
subject: Metastases

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: to set out essential information about peritoneal metastases, to provide general knowledge about diagnostic imaging of peritoneal lesions, to indicate several scoring systems that are used in determining the extent of peritoneal carcinomatosis, to...
Exequias para cuerpos prostituidos en dos novelas latinoamericanas
Creators: name: Bianchi, Paula Daniela
Publisher: name: Università degli  Studi di Milano
Year: 2010
Subjects: cuerpos; prostitutas; exclusión; cuerpos muertos; literatura latinoamericana

description: This paper reflects on the triangulation between literature, dead bodies and prostitution as a productive mechanism for studying the prostitute's body as a site of both systemic violence and potential agency in two texts of Latin American literature: La novia oscura (1999) and Qué raro que me llame Guadalupe (1999) by Myriam Laurini.
This analysis was selected one fragment of each novel, where the dead bodies of prostitutes as protagonists. From these textual mapping is woven associated with different modes of production that cross symbolic scenes, with different notions of funeral rituals and "uses" of these bodies present negotiations and strategies that involve the element where ritual and staging of bodies will be highly relevant.
In the speech of the body (Grosso: 2007) died of prostitutes and the threat desire are articulated within an area of edge and center simultaneously. The dead body is desired prostituted and rejected as a result of discrimination based on a structured regulatory culture, historically, between hiding and display within an exclusive system that transforms the body into something monstrous. So what are the tactics that show these bodies where they converge various covenants that are beyond the control mechanisms and acceptability?  What fears and desires that their exposure occurs at a funeral?
description: Altre Modernità, No 4 (2010): La morte e i suoi riti nella cultura contemporanea
Stories Told in Circles: A Journey Seeking Holistic Mental Health and Wellness Supports for UCalgary Indigenous Post-Secondary Students
Creators: name: Gladue, Keeta
Publisher: name: Social Work
Year: 2022
Subjects: subject: Indigenous
subject: Indigenous Mental Health
subject: Indigenous Student Services
subject: Holistic Wellness
subject: Indigenous Holistic Wellness
subject: Mental Health
subject: Student Wellness Services
subject: Education--Adult and Continuing
subject: Education--Administration
subject: Social Work
subject: FOS: Sociology
subject: Health Sciences--Mental Health

description: Indigenous learners attending Canadian post-secondary campuses encounter significant barriers to their holistic mental health and wellness in education. There are a number of factors that contribute to the challenges experienced by Indigenous students including: institutional and systemic racism and discrimination, ongoing effects of residential school, and underrepresentation in post-secondary at the student, staff, faculty, and leadership levels. This research project invited current Indigenous University of Calgary students to share stories and provide feedback on the University of Calgary’s mental health services and supports. Under the guidance of Elder Kerrie Moore, data collection was conducted through a Circle ceremony with four Indigenous student participants. The main themes identified were: nâtawihiwewin (Indigenous mental health providers), sîhkimitowin (building kinship and community), pakosêyihta ka îyihtasomakahk (inspiration and motivation), and nîkân isîhcikêwin (ceremony). This study concludes that long-term institutional investments of resources (such as financial, expertise, space, and networks in Indigenous communities) are needed in order to provide meaningful holistic supports for Indigenous learners.
Locality in Theory Space
Creators: name: Kahn, Yonatan
name: Thaler, Jesse
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Locality is a guiding principle for constructing realistic quantum field theories. Compactified theories offer an interesting context in which to think about locality, since interactions can be nonlocal in the compact directions while still being local in the extended ones. In this paper, we study locality in "theory space", four-dimensional Lagrangians which are dimensional deconstructions of five-dimensional Yang-Mills. In explicit ultraviolet (UV) completions, one can understand the origin of theory space locality by the irrelevance of nonlocal operators. From an infrared (IR) point of view, though, theory space locality does not appear to be a special property, since the lowest-lying Kaluza-Klein (KK) modes are simply described by a gauged nonlinear sigma model, and locality imposes seemingly arbitrary constraints on the KK spectrum and interactions. We argue that these constraints are nevertheless important from an IR perspective, since they affect the four-dimensional cutoff of the theory where high energy scattering hits strong coupling. Intriguingly, we find that maximizing this cutoff scale implies five-dimensional locality. In this way, theory space locality is correlated with weak coupling in the IR, independent of UV considerations. We briefly comment on other scenarios where maximizing the cutoff scale yields interesting physics, including theory space descriptions of QCD and deconstructions of anti-de Sitter space.
description: 40 pages, 11 figures; v2: references and clarifications added; v3: version accepted by JHEP
Staging Death, Translating Death, Rehearsing Death: A Photographer’s Apprenticeship in Dying
Creators: name: Fargione, Daniela
Publisher: name: Università degli  Studi di Milano
Year: 2010
Subjects: Claudio Cravero; Photography; Death; Violence; Translation

description: The preponderance of death imagery in the mass media and a recent interest of photography in the practice of death suggest the need to reevaluate our approach to death and dying, especially when violence is involved. This essay is a case study of History of Violence, Claudio Cravero's last photographic project. His collection of "portraits" reproduce apparent dead bodies, mostly attacked in their own domestic spheres, but neither the perpetrator of death (a mysterious murderer?), nor the weapon used (an omnipresent knife), should be considered as main focal points of the artist's inquiry. The undoubtful protagonist of these photographs, instead, is the light, that illuminates fear: not of death itself, rather of the obnoxious indifference to it, as the result of generalized death imagery saturation.
    The staged apparent death displayed in Cravero's photographs serve both as a memento mori and as a strategy to come to terms with the idea of death. In short, it is an apprentship in dying through a domesticating translation practice. Eventually, Cravero's History of Violence offers a complex reflection on the interplay between each individual story and macrolevel social History, thus providing some hypotheses of where violence and death fit in that odd geometry of time and space that we call life.
description: Altre Modernità, No 4 (2010): La morte e i suoi riti nella cultura contemporanea
title: Encounter
titleType: Subtitle
Creators: name: Rasouli Chizari, Golbon
Publisher: name: The Dynamic Archive
Year: 2021
Subjects: Digital Media
Design

description: How often do you feel lonely? If you’d say that you experience loneliness sometimes or evenalways, you are not alone. According to a new survey of 20,000 Americans, loneliness is atepidemic proportions.Encounter is an experimental project which puts humans to the test of loneliness.It is a stimulus for people to think about loneliness and face it the way they want. The emotion thatthese days, despite the Coronavirus, is more sensitive. The hugging became weak in everyday life,from both physical and spiritual needs. This project provides a position to embrace. You can sit ona chair and hug the structure.A garment covers the back of the chair with pillows and magnets under the sleeves.You can experience the feeling of being hugged by bringing the sleeves closer.
title: Shear wave characteristics of non-breast cancer malignancies
Creators: name: Lawson, Brooke
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Neoplasia
subject: Diagnostic procedure
subject: Elastography
subject: Breast

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To provide a pictorial representation of the shear wave appearances of rare non-breast cancer malignancies that may involve the breast, and to describe the histopathological features where...
Tests of Lorentz and CPT violation with MiniBooNE neutrino oscillation excesses
Creators: name: Katori, Teppei
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Violation of Lorentz invariance and CPT symmetry is a predicted phenomenon of Planck-scale physics. Various types of data are analyzed to search for Lorentz violation under the Standard-Model Extension (SME) framework, including neutrino oscillation data. MiniBooNE is a short-baseline neutrino oscillation experiment at Fermilab. The measured excesses from MiniBooNE cannot be reconciled within the neutrino Standard Model; thus it might be a signal of new physics, such as Lorentz violation. We have analyzed the sidereal time dependence of MiniBooNE data for signals of the possible breakdown of Lorentz invariance in neutrinos. In this brief review, we introduce Lorentz violation, the neutrino sector of the SME, and the analysis of short-baseline neutrino oscillation experiments. We then present the results of the search for Lorentz violation in MiniBooNE data. This review is based on the published result (ArXiv:1109.3480).
description: Preprint of an article submitted for consideration in Modern Physics Letter A \c{opyright} 2012 [copyright World Scientific Publishing Company] http://www.worldscientific.com/worldscinet/mpla
Table S4 Primers of 8 validated testis derived circRNAs for general and quantitive RT-PCR from Identification and characterization of circular RNAs in Qinchuan cattle testis
Creators: name: Gao, Yuan
name: Wu, Mingli
name: Fan, Yingzhi
name: Li, Shipeng
name: Lai, Zhenyu
name: Huang, Yongzhen
name: Lan, Xianyong
name: Lei, Chuzhao
name: Chen, Hong
name: Dang, Ruihua
Publisher: name: The Royal Society
Year: 2018

description: Circular RNA (circRNA) is a new class of non-coding RNA that has recently attracted researchers' interest. Studies have demonstrated that circRNA can function as microRNA sponges or competing endogenous RNAs. Although circRNA has been explored in some species and tissues, the genetic basis of testis development and spermatogenesis in cattle remains unknown. We performed ribo-depleted total RNA-Seq to detect circRNA expression profiles of neonatal (one week old) and adult (4 years old) Qinchuan cattle testes. We obtained 91 112 596 and 80 485 868 clean reads and detected 21 753 circRNAs. A total of 4248 circRNAs were significantly differentially expressed between neonatal and adult cattle testes. Among these circRNAs, 2225 were upregulated, and 2023 were downregulated in adult cattle testis. Genomic feature, length distribution and other characteristics of the circRNAs in cattle testis were studied. Moreover, Gene Ontology and KEGG pathway analyses were performed for source genes of circRNAs. These source genes were mainly involved in tight junction, adherens junction, TGFβ signalling pathway and reproduction, such as PIWIL1, DPY19L2, SLC26A8, IFT81, SMC1B, IQCG and TTLL5. CircRNA expression patterns were validated by RT-qPCR. Our discoveries provide a solid foundation for the identification and characterization of key circRNAs involved in testis development or spermatogenesis.
La tomba dell’architettura. Il funerale mediatico dell’edificio e della città
Creators: name: Boni, Federico
Publisher: name: Università degli  Studi di Milano
Year: 2010
Subjects: MORTE; MEDIA; ARCHITETTURA CONTEMPORANEA; SOCIOLOGIA URBANA

description: It seems that the process of secularization of our culture has made it impossible for us to legitimate death through its ritualization, thus causing its repression. The article seeks to examine the role played by the media and architecture in a process of re-ritualization of death, especially in their function of filling the void of sacredness, through a symbolic metabolization of the fear of death in our late-modern or post-modern civilization. The relationship between media, death and architecture is particularly frequent, especially in the studies of architecture historians and critics, and it seems to be directly correlated to the media texts' degree of spectacularity. The examination of movies and tv programs reveals the many media discourses that correlate architecture to death: the death of architecture, that is, the death of the building (as in the images of 11/9); the death of urbanism, that is, the death of the cities (in this case, disaster movie genre is the privileged scenario wherein the destruction of the metropolis is spectacularized); and the death of the architect himself (as in Peter Greenaway's movie The Belly of an Architect). The article ends with a brief discussion on the very first corpse of architecture: that is, that of the user, removed from the images of the architectural project, as if it could contaminate the purity of the architect's work of art.
description: Altre Modernità, No 4 (2010): La morte e i suoi riti nella cultura contemporanea
title: Calvaria not so trivia—interesting changes noted in the cranial vault on imaging
Creators: name: Ramesh, Nagabathula
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Anatomy
subject: Bones
subject: Neuroradiology brain
subject: CT
subject: Computer Applications-3D
subject: Education
subject: Congenital
subject: Developmental disease
subject: Infection

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The purpose of the presentation is to briefly review the various interesting changes in the cranial vault seen on CT scan of the...
Gauss-Bonnet braneworld redux: A novel scenario for the bouncing universe
Creators: name: Maeda, Hideki
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We propose a new scenario for the bouncing universe in a simple five-dimensional braneworld model in the framework of Einstein-Gauss-Bonnet gravity, which works even with ordinary matter on the brane. In this scenario, the so-called branch singularity located at a finite physical radius in the bulk spacetime plays an essential role. We show that a three-brane moving in the bulk may reach and pass through it in spite of the fact that it is a curvature singularity. The bulk spacetime is extended beyond the branch singularity in the C^0 sense and then the branch singularity is identified as a massive thin shell. From the bulk point of view, this process is the collision of the three-brane with the shell of branch singularity. From the point of view on the brane, this process is a sudden transition from the collapsing phase to the expanding phase of the universe. The present result opens a completely new possibility to achieve the bouncing brane universe as a higher-curvature effect.
description: 34 pages, 3 figures, 2 tables; v2, sections rearranged, typos corrected; v3, final version to appear in Physical Review D
Geochemical fingerprinting approaches to determine the origin of fluids produced from Duvernay Formation wells in west-central Alberta, Canada
Creators: name: Grimeau, Kevin N
Publisher: name: Science
Year: 2022
Subjects: subject: Duvernay
subject: Duvernay Formation
subject: Devonian
subject: Geochemistry
subject: FOS: Earth and related environmental sciences
subject: Isotope Geochemistry
subject: Geochemical Fingerprinting
subject: Water Analyses
subject: Gas Analyses
subject: Alberta
subject: Hydraulic Fracturing
subject: Canada
subject: Produced Water
subject: Oil
subject: Gas
subject: Kaybob
subject: Unconventional Reservoir
subject: Geochemistry
subject: Geology

description: The focus on sustainable hydrocarbon development in Canada continues to intensify. While much of the current focus is on reducing greenhouse gas emissions, other aspects are equally important such as reducing unwanted by-products of resource extraction, including formation water. The objective of this thesis was to evaluate and identify the sources of fluid production from Duvernay Formation wells in west-central Alberta, Canada. Three horizontal Duvernay Formation wells and a vertical cored well were incorporated in the study. A robust set of gas, water, and core material samples were collected from the study wells in addition to data from public and internal databases. Chemical and isotopic analyses were performed on the samples to develop a stratigraphic geochemical model for the study area to determine the origin of produced fluids in the study area.The stratigraphic geochemical model generated from hydrocarbon gas composition and ?13CC2-C3 isotopic analyses revealed produced gas is sourced almost entirely from the Duvernay Formation. Chemical and isotopic analyses (?18Owater, ?2Hwater, and ?34SSO4) from water samples revealed that produced water originates primarily from the formation fluids and not from injected freshwater flowback. Flowback water samples revealed a rapid transition from a freshwater endmember towards a high-salinity brine endmember. Over the 5-month study period, <4 % of the total injected freshwater volume used during hydraulic fracturing was recovered.Chemical and isotopic analyses on solute extracts from core material and on produced brine samples identified carbonate intervals from the upper 47 meters of the underlying Waterways Formation as the likely primary source of produced water in the horizontal study wells. Stratigraphic intervals, including the Duvernay, likely contribute small volumes of water, however the Duvernay’s water fingerprint is overwhelmed by the geochemical fingerprint of water from the Upper Waterways that contained elevated Mg/K and low Na/Ca solute ratios. Naturally occurring faults/fractures and/or hydraulic fractures that connect to the Upper Waterways are the suspected mechanisms behind high water production in the study area. Chemical and isotopic techniques are a suitable tool to identify the sources of fluids produced from the Duvernay Formation.
title: German and English interview guides as part of the ReZeitKon project (2020-2021)
title: Interviewleitfäden aus dem Projekt ReZeitKon in deutscher und englischer Sprache (2020-21)
titleType: AlternativeTitle
Creators: name: Frank, Pascal
name: Grauer, Claire
Publisher: name: Medien- und Informationszentrum, Leuphana Universität Lüneburg
Year: 2023
Subjects: Schulalltag
Unterricht
Lernen
COVID-19
Pandemie
Schulschließung
Home Schooling
Auswirkung
Alltagsverhalten
Schüler
Lehrkräfte
Eltern
Wahrnehmung
Day-to-Day School Life
School Education
Learning
Pandemic
School Closure
Impact
Daily Behavior
Student
Teacher
Parents
Perception

description: Bei den Daten handelt es sich um qualitative Interviewleitfäden zur Befragung von Schülerinnen und Schülern, Lehrkräften, Eltern und weiteren Ressourcenpersonen im Rahmen einer Forschung zum Zeitempfinden von Schülerinnen und Schülern deutscher Sekundarschulen während der pandemiebedingten Schulschließungen in den Jahren 2020 und 2021. Die erste Befragungsrunde fand im Zeitraum von April bis Oktober 2020 statt. Eine zweite Befragungsrunde mit leicht angepassten Interviewleitfäden wurde zwischen Februar und März 2021, während der zweiten Phase längerer Schulschließungen in Deutschland, durchgeführt.
description: The data consists of qualitative interview guidelines for surveying secondary school students, teachers, parents and other resource persons as part of research into how students at German secondary schools perceive time during the pandemic-related school closures in 2020 and 2021. The first round of interviews took place between April and October 2020. A second round of interviews with slightly adapted interview guidelines was conducted between February and March 2021, during the second phase of extended school closures in Germany.
description: Interview
Worldwide Prevalence and Incidence of Non-Alcoholic Fatty Liver Disease (NAFLD) in the 21st Century: A Systematic Review and Meta-Analysis
Creators: name: Riazi, Kiarash
Publisher: name: Cumming School of Medicine
Year: 2021
Subjects: subject: Health And Environmental Sciences
subject: Health Sciences--Medicine and Surgery
subject: Health Sciences--Epidemiology
subject: Health Sciences--Public Health
subject: Health Sciences--General

description: Non-alcoholic fatty liver disease (NAFLD) is defined as the presence of lipid deposition in more than 5% of hepatocytes, also known as fatty liver, in the absence of any history of excessive alcohol use or secondary causes of fatty liver. NAFLD is the most common liver disorder worldwide and the leading cause of liver-related morbidity and mortality, mainly because of cirrhosis, end-stage liver disease, liver transplant, and an increased incidence of hepatocellular carcinoma.The prevalence of NAFLD is constantly rising. Due to a silent presentation, high prevalence, and the detrimental outcomes associated with it, NAFLD is a major global health problem. Since there are currently no approved treatments for NAFLD, disease prevention is the only available option for reducing the disease burden. Since primary epidemiological data are the crucial cornerstones for every public health and preventive medicine attempt, updated and accurate epidemiological data are of utmost importance. There are currently a few existing research publications on the prevalence and incidence of NAFLD worldwide, which are either outdated, methodologically imperfect, or geographically restricted. Therefore, there is a need to update current data and accurately estimate NAFLD's worldwide prevalence and incidence.We performed a systematic review to identify all the studies reporting on the prevalence or incidence of NAFLD among the general adult population of different world regions over the past two decades. We used a random-effects meta-analysis method to calculate overall or sex-specific pooled prevalence or incidence rates. We also created static and interactive choropleth maps of pooled data to highlight the geographic differences in NAFLD prevalence/incidence.We estimated that the overall prevalence of NAFLD is appreciably higher than what had previously been assessed and is growing at an alarming rate. Furthermore, our findings show that the epidemiological reports regarding NAFLD from many parts of the world are missing. A dramatic rise in prevalence should drive enhanced awareness of NAFLD among primary care physicians, public health specialists, and health policymakers to encourage the development of more effective preventive policies.
Robust RNA-seq data analysis using an integrated method of ROC curve and Kolmogorov–Smirnov test
Creators: name: Yang, Shengping
name: Zhang, Kun
name: Fang, Zhide
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: It is a common approach to dichotomize a continuous biomarker in clinical setting for the convenience of application. Analytically, results from using a dichotomized biomarker are often more reliable and resistant to outliers, bi-modal and other unknown distributions. There are two commonly used methods for selecting the best cutoff value for dichotomization of a continuous biomarker, using either maximally selected chi-square statistic or a ROC curve, specifically the Youden Index. In this paper, we explained that in many situations, it is inappropriate to use the former. By using the Maximum Absolute Youden Index (MAYI), we demonstrated that the integration of a MAYI and the Kolmogorov–Smirnov test is not only a robust non-parametric method, but also provides more meaningful p value for selecting the cutoff value than using a Mann-Whitney test. In addition, our method can be applied directly in clinical settings.
Investigating the methodological applicability of intersectionality to physical activity and smoking in Canada
Creators: name: Abichahine, Hayfa
Publisher: name: University of British Columbia
Year: 2013

description: BACKGROUND: In Canada, substantial health inequities have been documented by income, education, gender, race, and sexuality. Researchers examining such inequities have typically employed ‘additive’ analyses where these variables are treated independently of one another. Some scholars have argued that the additive approach cannot fully illuminate health inequities by class, gender, race, and sexuality, calling for ‘multiplicative’ approaches inspired by intersectionality theory to replace additive approaches. PURPOSE: I investigate the applicability of intersectionality theory for explicating two health practices - physical exercise and smoking - using Canadian data. I predict that intersections of classism, patriarchy, racism, and heterosexism at macro levels of Canadian society affect the incidence of exercise and smoking at the individual level, in the case of physical exercise as a desirable pursuit which is facilitated by the privilege that accrues to multiple dominant-group identities and in the case of smoking as a coping mechanism for dealing with the oppressive stressors that accrue to multiple subordinate-group identities. METHODS: Informed by the theoretical underpinnings of current intersectional scholarship, I compare the ability of the additive and intersectional approaches to explicate these two health practices in Canada. Using nationally-representative data from the Canadian Community Health Survey Cycles 2.1 and 3.1 and binary logistic regression modelling, I examine and compare the main effects of class, race, gender, and sexuality (additivity) and then four-, three-, and two-way interaction effects between class, race, gender, and sexuality (multiplicativity) as predictors of physical activity and smoking. RESULTS: I find that results from the additive models are consistent with previous empirical research on physical activity and smoking. The interaction models produce statically significant three- and two-way interactions for physical activity and smoking that are complex in nature and consistent with some but not all of the predictions derived from intersectionality theory. CONCLUSION: This study challenges prevailing understandings of social causes of health behaviours by class, gender, race, and sexuality that have been generated by additive modes of analysis. The study also suggests that, in regard to physical activity and smoking, some but perhaps not all tenets of intersectionality are potentially useful in explaining these health practices.
On a family of analytic discs attached to a real submanifold $M\subset\mathbb{C}^{N+1}$
Creators: name: Burcea, Valentin
Publisher: name: arXiv
Year: 2012
Subjects: subject: Complex Variables (math.CV)
subject: Differential Geometry (math.DG)
subject: FOS: Mathematics

description: We construct a family of analytic discs attached to a real submanifold M \subset $\mathbb{C}^{N+1}$ of codimension $2$ defined near a CR singularity.
description: It has been implemented an Upgraded ERRATUM SUBMITTED for PUBLICATION. Few improvements implemented aside the published version having the purpose of improving the exposion of the paper
Decoupling with unitary approximate two-designs
Creators: name: Szehr, Oleg
name: Dupuis, Frédéric
name: Tomamichel, Marco
name: Renner, Renato
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: Consider a bipartite system, of which one subsystem, A, undergoes a physical evolution separated from the other subsystem, R. One may ask under which conditions this evolution destroys all initial correlations between the subsystems A and R, i.e. decouples the subsystems. A quantitative answer to this question is provided by decoupling theorems, which have been developed recently in the area of quantum information theory. This paper builds on preceding work, which shows that decoupling is achieved if the evolution on A consists of a typical unitary, chosen with respect to the Haar measure, followed by a process that adds sufficient decoherence. Here, we prove a generalized decoupling theorem for the case where the unitary is chosen from an approximate two-design. A main implication of this result is that decoupling is physical, in the sense that it occurs already for short sequences of random two-body interactions, which can be modeled as efficient circuits. Our decoupling result is independent of the dimension of the R system, which shows that approximate 2-designs are appropriate for decoupling even if the dimension of this system is large.
description: Published version
Pure Project Data Management Plan
Creators: name: Barbosa, Arménio J. M.
Publisher: name: Zenodo
Year: 2021
Subjects: Data Management Plan
DMP
PURE Project

description: The following document is the Deliverable 1.5_Data Management Plan (DMP) of the
 PURE Project, funded by the European Union’s Horizon 2020 research and innovation
 programme under grant agreement Number 899732.
 This document is the first version of the DMP, consisting of preliminary information
 regarding the type and format of data that will be collected and generated, its origin,
 data utility and how PURE project research data will be findable, accessible,
 interoperable and reusable (i.e. FAIR).
 The purpose of DMP is to provide the members of the consortium with an analysis of
 the main elements of the data management policy regarding all the datasets generated
 by the project. This Data Management Plan (DMP) has been prepared by taking into
 account the template of the “Guidelines on Data Management in Horizon 2020”. The Pure project is funded by the European Union’s Horizon 2020 program under grant agreement No. 899732.
description: {"references": ["Guidelines on FAIR Data Management in Horizon 2020, https://ec.europa.eu/research/participants/data/ref/h2020/grants_manual/hi/oa_pilot/h2020-hi-oa-data-mgt_en.pdf"]}