cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
sj-pdf-1-qhr-10.1177_10497323211027130 – Supplemental material for “I Am Okay With It, But I Am Not Going to Do It”: The Exogenous Factors Influencing Non-Participation in Medical Assistance in Dying
Creators: name: Brown, Janine
name: Goodridge, Donna
name: Thorpe, Lilian
name: Crizzle, Alexander
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, sj-pdf-1-qhr-10.1177_10497323211027130 for “I Am Okay With It, But I Am Not Going to Do It”: The Exogenous Factors Influencing Non-Participation in Medical Assistance in Dying by Janine Brown, Donna Goodridge, Lilian Thorpe and Alexander Crizzle in Qualitative Health Research
PERCEPTIONS OF PURPLE TEAMS AMONG CYBERSECURITY PROFESSIONALS
Creators: name: Chowdhury, Siddharth
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: System and network security
Technology management
Innovation management

description: With constant technological advancements, the attacks against existing infrastructure is constantly increasing and causing more damage. The current Red and Blue team approach to cybersecurity assessments is used to test the effectiveness of security defenses and in identifying vulnerabilities before they are exploited. Due to a lack of collaboration and inherently contradicting natures of these teams, the credibility of audits is impacted. While this has led to the synergistic and collaborative Purple team, it is important to understand how cybersecurity professionals perceive this new concept and its function. Analyzing perceptions of self-reported cybersecurity professionals via an online survey showed most believed Purple teams were beneficial and should be created from and collaborate with Red and Blue teams. However, past Red team experience was negatively linked to perceived benefit. Those who had more years of experience or had been on Red teams were more likely to believe Purple teams may have ownership or learning issues. Furthermore, professionals identified active managerial involvement and project clarity as critical success factors for Purple teams. Alongside these, management could help find the right skillset, provide resources, and offer active direction in order to avoid issues and maximize outcomes. Based on assessment relevance, a collaborative agreed-upon methodology for Red, Blue, and Purple teams was provided.
ZAMONAVIY DARS VA DARS TAHLILINI O'TKAZISHGA NISBATAN YONDASHUVLAR
Creators: name: Nazarova, Farangiz
name: Yaxiyaxonova, Muxiba
Publisher: name: Zenodo
Year: 2025

description: Mazkur maqolada zamonaviy dars va dars tahlilini o‘tkazishga nisbatan yondashuvlar tahlil qilinadi. Bugungi kunda ta’lim jarayonida innovatsion texnologiyalar va interfaol metodlardan samarali foydalanish muhim ahamiyat kasb etmoqda. Tadqiqot natijalari shuni ko‘rsatadiki, an’anaviy dars usullari o‘quvchilarning faolligi va mustaqil fikrlash qobiliyatini yetarli darajada rivojlantirmaydi. Shu sababli, "Jigsaw", "Aqliy hujum", "Klaster" kabi interfaol usullarning tatbiqi dars jarayonining samaradorligini oshirishga xizmat qiladi. Maqolada, shuningdek, dars tahlilini samarali tashkil etishning ahamiyati va zamonaviy baholash tizimlari, jumladan, refleksiya, kuzatuv hamda raqamli texnologiyalar asosida tahlil qilish usullari yoritiladi. Ushbu maqola pedagoglar, ta’lim muassasalari rahbarlari va innovatsion ta’lim metodlariga qiziquvchi mutaxassislar uchun foydali bo‘lib, zamonaviy dars tamoyillari, samarali ta’lim strategiyalari va dars tahlilining ahamiyatini chuqurroq tushunishga yordam beradi.
sj-pdf-1-qhr-10.1177_10497323211028829 – Supplemental material for Theorizing Factors Mediating With the Implementation of a Patient Feedback on Safety Intervention Implemented in the Primary Care Setting
Creators: name: Beks, Hannah
name: Hernan, Andrea L.
name: Giles, Sally
name: Malakellis, Mary
name: Mc Namara, Kevin P.
name: Versace, Vincent L.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, sj-pdf-1-qhr-10.1177_10497323211028829 for Theorizing Factors Mediating With the Implementation of a Patient Feedback on Safety Intervention Implemented in the Primary Care Setting by Hannah Beks, Andrea L. Hernan, Sally Giles, Mary Malakellis, Kevin P. Mc Namara and Vincent L. Versace in Qualitative Health Research
MPEC 2025-F86 : 2025 FX2
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2025
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2025 FX2

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Dietary behaviour and parental socioeconomic position among adolescents: the German Health Interview and Examination Survey for Children and Adolescents 2003–2006 (KiGGS)
Creators: name: Finger, Jonas
name: Varnaccia, Gianni
name: Tylleskär, Thorkild
name: Lampert, Thomas
name: Mensink, Gert
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2015
Subjects: subject: Germany
subject: Adolescents
subject: Nutrition
subject: Socioeconomic position
subject: Physical activity
subject: 610 Medizin

description: Background: The positive association between parental socioeconomic position (PSEP) and health among adolescents may be partly explained by dietary behaviour. We investigated the associations between fruit intake, vegetable intake, energy-dense food intake, the Healthy Nutrition Score for Kids and Youth (HuSKY) and parental education in a nationwide, cluster-randomized sample of adolescents in Germany. Methods: The German Health Interview and Examination Survey for Children and Adolescents 2003–2006 (KiGGS) included 17,641 individuals aged 0–17 years and their parents. Complete information on relevant variables was available for 6359 individuals in the 11–17 age group. The associations between nutrition indicators and parental education were analysed separately for boys and girls, using multivariate logistic regression analysis. Odds ratios (ORs) adjusted for age, region, income, occupation, physical activity and weight status related variables, were calculated for the associations between parental education and nutrition indicators. Results: After full adjustment, higher parental education level was associated with lower energy-dense food intake – with an OR of 1.3 (95 % CI 1.0–1.7) for boys with secondary educated parents and 1.8 (1.4–2.3) for boys with tertiary educated parents compared to boys with primary educated parents; the corresponding ORs for girls were 1.2 (0.9–1.5) and 1.6 (1.2–2.2). Higher parental education was associated with higher fruit intake – with an OR of 1.3 (1.0–1.7) for boys with secondary educated parents and 2.0 (1.5–2.7) for boys with tertiary educated parents compared to boys with primary educated parents; the corresponding ORs for girls were 1.0 (0.8–1.4) and 1.5 (1.0–2.1). Among boys and girls with tertiary educated parents compared to those with primary educated parents an OR of 1.3 (CI boys: 1.0–1.7, CI girls: 1.0–1.6) was observed for high vegetable intake. Among boys with tertiary educated parents compared to boys with primary educated parents an OR of 1.6 (1.2–2.2) was observed for a high HuSKY; the corresponding OR for girls was 1.5 (1.1–1.9). Conclusions: A high PSEP is associated with consumption of less energy-dense food, more fruits and vegetables and more favourable overall dietary behaviour. Preferably school-based interventions are needed to promote healthy dietary behaviour among German adolescents and a special effort is needed to reach adolescents from low-PSEP families.
Determining One-Shot Control Criteria in Western North American Power Grid with Swarm Optimization
Creators: name: Vaughan, Gregory
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Electrical engineering not elsewhere classified

description: The power transmission network is stretched thin in Western North America. When generators or substations fault, the resultant cascading failures can diminish transmission capabilities across wide regions of the continent. This thesis examined several methods of
determining one-shot controls based on frequency decline in electrical generators to reduce the effect of one or more phase faults and tripped generators. These methods included criteria based on indices calculated from frequency measured at the controller location. These indices included criteria based on local modes and the rate of change of frequency.
This thesis primarily used particle swarm optimization (PSO) with inertia to determine a well-adapted set of parameters. The parameters included up to three thresholds for indices calculated from frequency. The researchers found that the best method for distinguishing between one or more phase faults used thresholds on two Fourier indices. Future lines of research regarding one-shot controls were considered.

A method that distinguished nearby tripped generators from one or more phase faults and load change events was proposed. This method used a moving average, a negative
threshold for control, and a positive threshold to reject control. The negative threshold for the moving average is met frequently during any large transient event. An additional index must be used to distinguish loss of generation events. This index is the maximum value of the moving average up to the present time and it is good for distinguishing loss of
generation events from transient swings caused by other events.

This thesis further demonstrated how well a combination of controls based on both rate of change of frequency and local modes reduces instability of the network as determined by both a reduction in RMSGA and control efficiency at any time after the events.
This thesis found that using local modes is generally useful to diagnose and apply one-shot controls when instability is caused by one or more phase faults, while when disconnected generators or reduced loads cause instability in the system, the local modes did not distinguish between loss of generation capacity events and reduced load events. Instead, differentiating based on the rate of change of frequency and an initial upward deflection of frequency or an initial downward deflection of frequency did distinguish between these types of events.
Additional file 1 of Measuring deliberate reflection in residents: validation and psychometric properties of a measurement tool
Creators: name: Blum, Richard H.
name: Mai, Christine L.
name: Mitchell, John D.
name: Saddawi-Konefka, Daniel
name: Cooper, Jeffrey B.
name: Shorten, George
name: DunnGalvin, Audrey
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Mental Health

description: Additional file 1: Supplementary File Section 1. Key terms and definitions of reflection. Supplementary File Section 2. Modified REFLECT Scoring Rubric. Supplementary File Section 3. Vignette with Essential Design Elements, Trainee Response, “Rules of Thumb” for Scoring and Qualitative and Qualitative Scoring. Supplementary File Section 4. Steps in Rater Training.
sj-pdf-2-min-10.1177_2053369120985743 - Supplemental material for The testosterone prescribing practice of BMS menopause specialists
Creators: name: Scott, A
name: Holloway, D
name: Rymer, J
name: Bruce, D
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111402 Obstetrics and Gynaecology
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-2-min-10.1177_2053369120985743 for The testosterone prescribing practice of BMS menopause specialists by D Holloway J Rymer and D Bruce in Post Reproductive Health
The antidepressants and sexual dysfunction: a pharmacovigilance-pharmacodynamic study of the FDA adverse event reporting system
Creators: name: Cheng, Yu
name: Chen, Youjun
name: Zhao, Xue
name: Mou, Fan
name: Tan, Yingting
name: Wang, Wanying
name: Qian, Ruiyi
name: Xu, Qingqing
name: Yu, Shunying
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Sexual dysfunction (SD) is a commonly occurring yet often underestimated adverse event associated with the use of antidepressants. This study aimed to analyze the reporting of SD associated with the use of antidepressants in comparison with one another, and to explore potential receptor mechanisms based on the real-world data from the Food and Drug Administration Adverse Event Reporting System (FAERS). Disproportionality analysis was conducted based on FAERS reports (2004 Q1 to 2024 Q2) using reporting odds ratios (ROR) and information components (IC) methods. Spearman correlation analysis was performed to explore the relationship between ROR and the related receptor-binding properties. In total, 233 significant signals involving 9767 cases were included. The analysis confirmed that the selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors exhibited significant signals, consistent with previous research. Additionally, unexpected signals were detected for vortioxetine (ROR = 13.60), suggesting a potential risk despite its low reported incidence rates of SD. Spearman correlation analysis revealed potential effects for the binding affinities of serotonin transporter, 5-HT1B, and 5-HT2A receptors on reduced sexual desire. The present investigation has detected new and unexpected signals of antidepressant-related SDs. Further research is needed to validate and clarify the observed associations.
Pneumatosis intestinalis associated with α-glucosidase inhibitors: a pharmacovigilance study of the FDA adverse event reporting system from 2004 to 2022
Creators: name: Chen, Yiqian
name: Xiao, Yao
name: Lian, Guanghui
name: Yi, Jun
name: Liu, Xiaowei
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health

description: A-glucosidase inhibitors (AGIs) are suitable for type 2 diabetes mellitus patients with carbohydrate-rich diets while were reported associated with the rare but potentially life-threatening pneumatosis intestinalis (PI). Data from the US Food and Drug Administration Adverse Event Reporting System (FAERS) were examined for AGIs, acarbose, voglibose, miglitol, or other anti-hyperglycemic drug classes. The reporting odds ratio (ROR), proportional reporting ratio, gamma poisson shrinker, and bayesian confidence propagation neural network were applied to determine the safety signals, which were performed under two other models to control for bias from type 2 diabetes mellitus and other anti-hyperglycemic drugs. We found a significantly higher reporting of PI in all AGIs group [ROR = 73.85 (61.56–88.58)]. When further subdivided, voglibose and miglitol had a larger ROR than acarbose whether models were adjusted or not. The safety signals of biguanides, sulfonylureas, thiazolidinediones, dipeptidyl peptidase 4 inhibitors inhibitors, glucagon-like peptide-1 receptor agonists, sodium-glucose co-transporter-2 inhibitors, and other drug classes were not detected in three models. Our study identified the safety signals of the PI-AGIs pair, primarily based on disproportionality analysis while controlling for confounders such as the disease-associated risk of PI and concomitant drug exposure.
High Theory Podcast Invitation 2
Creators: name: Adams, Kim
name: Bosu, Saronik
Publisher: name: unknown
Year: 2021
Subjects: subject: Politics and government
subject: Societies
subject: Criticism
subject: Culture
subject: Art
subject: Literature

description: We are hosting a happy hour to celebrate our podcast "High Theory" in conjunction with the MLA conference.
We cannot buy you a drink, but we will charm you on Zoom with silly games like theory Pictionary.
Please join us on Saturday, January 9, any time between 7 and 8 pm EST.
RSVP to info@hightheory.net or visit www.hightheory.net to learn more.
Apologies for the short notice.
We would love to see you.
Safety of edaravone in real-world use: analysis based on FDA adverse event reporting system
Creators: name: Peng, Tao
name: Hu, Nan
name: Huang, Lan
name: Kang, Yalong
name: Yan, Yongmei
name: Zhang, Hui
name: Wan, Dongping
name: Jin, Xiaxia
name: Yang, Yifan
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Mental Health

description: Edaravone is a novel free radical scavenger utilized to treat amyotrophic lateral sclerosis (ALS). However, long-term safety data remain limited. Adverse event reports related to edaravone from the second quarter of 2017 to the second quarter of 2024 were extracted from the US Food and Drug Administration (FDA) Adverse Event Reporting System database (FAERS). Disproportionality analysis was conducted utilizing the reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian confidence propagation neural network (BCPNN), and multi-item gamma Poisson shrinker (MGPS) algorithms. A total of 3,149 adverse event reports related to edaravone were analyzed. The most common adverse reactions included systemic disorders and administration site reactions, nervous system disorders, respiratory system disorders, and surgical and medical procedures. New adverse reaction signals included disseminated intravascular coagulation, gastric fistula, sputum retention, excessive salivation, fractures, elevated cystatin C. The median onset time for adverse events was 43 days (interquartile range: 7–173 days). This study confirmed previously reported adverse events and identified several new ones associated with edaravone. These findings provide valuable insights for optimizing ALS patient management and highlight the need for further research into the mechanisms of these adverse reactions.
ELUCIDATING THE ROLE OF POLYBROMO-1 IN TARGETING THE PBAF COMPLEX UNDER STRESS
Creators: name: Porter, Elizabeth G
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Oncology and carcinogenesis not elsewhere classified
Cell development, proliferation and death
Epigenetics (incl. genome methylation and epigenomics)

description: DNA organization is an intricate and dynamic process. The approximately two meters of DNA in a single cell is wrapped around small proteins called histones. Histones can be compacted into dense coils or loosely distributed along DNA, allowing for cells to control gene expression. This combination of DNA and histones forms chromatin. This work has focused on understanding the role of Polybromo1 (PBRM1), which is a member of a chromatin remodeling complex. PBRM1 is mutated in 3% of all human cancers and is mutated in 40% of renal clear cell carcinomas (ccRCC), the most common type of kidney cancer. Through my work characterizing PBRM1 as a tumor suppressor, we have found PBRM1 acts as a stress sensor. PBRM1 is a member of the Polybromo1 BRG1 associating factors (PBAF) complex which is a subtype of the larger BAF family of chromatin remodelers. Although BAF is essential for cell viability, knockdown of PBRM1 shows minor phenotypic changes in many cell types under standard cell culturing conditions. However, when cells without PBRM1 experience external stress, the reactive oxygen species levels in the cells are elevated and remain high compared to cells with wild type PBRM1. Depending on the cellular environment of the cell, increase in ROS can be growth promoting or growth inhibiting. PBRM1 is a structurally unique protein, containing two bromo-adjacent homologs, a high mobility group and six tandem bromodomains. Due to the multiple reader domains, it is likely PBRM1 acts to target the complex. Taking advantage of a RCCC cell line not expressing PBRM1, we re-expressed full length PBRM1 containing an asparagine to alanine mutation in each bromodomain, disrupting the acetyl-lysine binding. We have found that the bromodomains are cooperative and are facilitating binding of PBAF to chromatin. We found defects in PBRM1’s ability to suppress growth, bind to chromatin, and regulate gene expression when any of the bromodomains were mutated besides the third bromodomain. These results correlated with patient data. Using acetylated histone peptides, we have identified potential combinations of marks that PBRM1 prefers over single marks. Further work needs to be done to characterize how these histone modifications are altered under stress and they contribute to the role of PBRM1 in stress response.
Additional file 3 of Corpus luteum presence in the bovine ovary increase intrafollicular progesterone concentration: consequences in follicular cells gene expression and follicular fluid small extracellular vesicles miRNA contents
Creators: name: da Silva Rosa, Paola Maria
name: Bridi, Alessandra
name: de Ávila Ferronato, Giuliana
name: Prado, Cibele Maria
name: Bastos, Natália Marins
name: Sangalli, Juliano Rodrigues
name: Meirelles, Flávio Vieira
name: Perecin, Felipe
name: da Silveira, Juliano Coelho
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Developmental Biology
subject: Cancer
subject: Virology
subject: Computational Biology

description: Supplementary Material 3.
In Silico Prediction and Experimental Confirmation of HA Residues Conferring Enhanced Human Receptor Specificity of H5N1 Influenza A Viruses
Creators: name: Schmier, Sonja
name: Mostafa, Ahmed
name: Haarmann, Thomas
name: Bannert, Norbert
name: Ziebuhr, John
name: Veljkovic, Veljko
name: Dietrich, Ursula
name: Pleschka, Stephan
Publisher: name: Robert Koch-Institut, Biologische Sicherheit
Year: 2015
Subjects: subject: Animals
subject: Humans
subject: Genetic Vectors/genetics
subject: Phenotype
subject: Mutation
subject: Cell Line
subject: Gene Expression
subject: Models Molecular
subject: Computer Simulation
subject: Virus Replication
subject: Models Biological
subject: Amino Acids
subject: Hemagglutinin Glycoproteins Influenza Virus/chemistry
subject: Hemagglutinin Glycoproteins Influenza Virus/genetics
subject: Influenza A Virus H5N1 Subtype/genetics
subject: Influenza A Virus H5N1 Subtype/metabolism
subject: Protein Conformation
subject: Receptors Virus/genetics
subject: Receptors Virus/metabolism
subject: Retroviridae/genetics
subject: Virus Attachment
subject: 610 Medizin

description: Newly emerging influenza A viruses (IAV) pose a major threat to human health by causing seasonal epidemics and/or pandemics, the latter often facilitated by the lack of pre-existing immunity in the general population. Early recognition of candidate pandemic influenza viruses (CPIV) is of crucial importance for restricting virus transmission and developing appropriate therapeutic and prophylactic strategies including effective vaccines. Often, the pandemic potential of newly emerging IAV is only fully recognized once the virus starts to spread efficiently causing serious disease in humans. Here, we used a novel phylogenetic algorithm based on the informational spectrum method (ISM) to identify potential CPIV by predicting mutations in the viral hemagglutinin (HA) gene that are likely to (differentially) affect critical interactions between the HA protein and target cells from bird and human origin, respectively. Predictions were subsequently validated by generating pseudotyped retrovirus particles and genetically engineered IAV containing these mutations and characterizing potential effects on virus entry and replication in cells expressing human and avian IAV receptors, respectively. Our data suggest that the ISM-based algorithm is suitable to identify CPIV among IAV strains that are circulating in animal hosts and thus may be a new tool for assessing pandemic risks associated with specific strains.
T-cell malignancies following CAR T-Cell therapy: insights from the FDA Adverse Event Reporting System (FAERS)
Creators: name: Di Napoli, Raffaella
name: Balzano, Nunzia
name: Ruggiero, Rosanna
name: Mascolo, Annamaria
name: Scavone, Cristina
name: di Mauro, Gabriella
name: Capuano, Annalisa
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: Hematology

description: Concern about post-CAR T-cell lymphomas has recently emerged. Analysis of pharmacovigilance data contributes to continuous safety monitoring, especially for newly authorized medicines, like CAR-T therapies. Individual case safety reports (ICSRs) reporting at least one CAR T-cell therapy as a suspect drug were extracted from the Food and Drug Administration Adverse Event Reporting System database up to 6 February 2024. Descriptive and disproportionality analysis were performed. Seventeen ICSRs reported T-cell malignancies associated with CAR T-cell therapy. Gender distribution was similar between females and males, and adult patients accounted for 41.2% of ICSRs. All cases were serious, with 41.2% resulting in death. The most reported Preferred Terms (PTs) for T-cell malignancies was ‘T-cell lymphoma’ (70.6%). Over 70% of ICSRs reported at least one other adverse event, predominantly gastrointestinal disorders (14.3%). Axicabtagene ciloleucel and tisagenlecleucel were associated with a statistically higher reporting frequency of T-cell lymphoma compared to all other drugs (p-value <0.001, for both). Statistically higher reporting frequencies of ‘Haematological malignant tumors’ and ‘Malignant lymphomas’ SMQs emerged when tisagenlecleucel was compared with axicabtagene ciloleucel (p-value <0.001, for both). Axicabtagene ciloleucel and tisagenlecleucel may be associated with a higher reporting frequency of T-cell lymphoma than other drugs.
sj-pdf-10-hpq-10.1177_13591053211027631 – Supplemental material for Causal attributions and perceived stigma for myalgic encephalomyelitis/chronic fatigue syndrome
Creators: name: Froehlich, Laura
name: Hattesohl, Daniel BR
name: Cotler, Joseph
name: Jason, Leonard A
name: Scheibenbogen, Carmen
name: Behrends, Uta
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-10-hpq-10.1177_13591053211027631 for Causal attributions and perceived stigma for myalgic encephalomyelitis/chronic fatigue syndrome by Laura Froehlich, Daniel BR Hattesohl, Joseph Cotler, Leonard A Jason, Carmen Scheibenbogen and Uta Behrends in Journal of Health Psychology
Continuous Physiological Monitoring Of Ambulatory Patients
Creators: name: Bonnici, Timothy
name: Charlton, Peter H
name: Alastruey, Jordi
name: Tarassenko, Lionel
name: Watkinson, Peter J
name: Beale, Richard
Publisher: name: Zenodo
Year: 2014
Subjects: wearable sensors
patient monitoring
electrocardiogram
photoplethysmogram

description: A poster originally presented at the "MEC Annual Meeting and Bioengineering14" conference (Imperial College London, 8th - 9th September 2014).
description: {"references": ["T. Bonnici et al., \"Testing of Wearable Monitors in a Real-World Hospital Environment: What Lessons Can Be Learnt?\", in Conf Proc 9th Wearable and Implantable BSNs. IEEE, 2012, pp. 79 - 84."]}
Genome Sequences of a Rat Polyomavirus Related to Murine Polyomavirus, Rattus norvegicus Polyomavirus 1
Creators: name: Ehlers, Bernhard
name: Richter, Dania
name: Matuschka, Franz-Rainer
name: Ulrich, Rainer G.
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2015
Subjects: subject: 610 Medizin

description: We amplified and sequenced six complete genomes of a polyomavirus from feral Norway rats (Rattus norvegicus) and from a long-term breeding colony derived from Norway rats. This virus, which is closely related to hamster polyomavirus and murine polyomavirus, may contribute to understanding the evolutionary history of rodent polyomaviruses.
Safety of Edaravone in real-world use: analysis based on FDA adverse event reporting system
Creators: name: Peng, Tao
name: Hu, Nan
name: Huang, Lan
name: Kang, Yalong
name: Yan, Yongmei
name: Zhang, Hui
name: Wan, Dongping
name: Jin, Xiaxia
name: Yang, Yifan
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Mental Health

description: Edaravone is a novel free radical scavenger utilized to treat amyotrophic lateral sclerosis (ALS). However, long-term safety data remain limited. Adverse event reports related to edaravone from the second quarter of 2017 to the second quarter of 2024 were extracted from the US Food and Drug Administration (FDA) Adverse Event Reporting System database (FAERS). Disproportionality analysis was conducted utilizing the reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian confidence propagation neural network (BCPNN), and multi-item gamma Poisson shrinker (MGPS) algorithms. A total of 3,149 adverse event reports related to edaravone were analyzed. The most common adverse reactions included systemic disorders and administration site reactions, nervous system disorders, respiratory system disorders, and surgical and medical procedures. New adverse reaction signals included disseminated intravascular coagulation, gastric fistula, sputum retention, excessive salivation, fractures, elevated cystatin C. The median onset time for adverse events was 43 days (interquartile range: 7-173 days). This study confirmed previously reported adverse events and identified several new ones associated with edaravone. These findings provide valuable insights for optimizing ALS patient management and highlight the need for further research into the mechanisms of these adverse reactions.
What influences availability of medicines for the community management of childhood illnesses in central Uganda? Implications for scaling up the integrated community case management programme
Creators: name: Bagonza, James
name: Rutebemberwa, Elizeus
name: Eckmanns, Tim
name: Ekirapa-Kiracho, Elizabeth
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2015
Subjects: subject: Uganda
subject: Drug
subject: Availability
subject: Childhood Illnesses
subject: Community health workers
subject: 610 Medizin

description: Background: The integrated Community Case Management (iCCM) of childhood illnesses strategy has been adopted world over to reduce child related ill health and mortality. Community Health workers (CHWs) who implement this strategy need a regular supply of drugs to effectively treat children under 5 years with malaria, pneumonia and diarrhea. In this paper, we report the prevalence and factors influencing availability of medicines for managing malaria, pneumonia and diarrhea in communities in central Uganda. Methods: A cross sectional study was conducted among 303 CHWs in Wakiso district in central Uganda. Eligible CHWs from two randomly selected Health Sub Districts (HSDs) were interviewed. Questionnaires, check lists, record reviews were used to collect information on CHW background characteristics, CHW’s prescription behaviors, health system support factors and availability of iCCM drugs. Multivariable logistic regression analysis was done to assess factors associated with availability of iCCM drugs. Results: Out of 300 CHWs, 239 (79.9 %) were females and mean age was 42.1 (standard deviation =11.1 years). The prevalence of iCCM drug availability was 8.3 % and 33 respondents (11 %) had no drugs at all. Factors associated with iCCM drug availability were; being supervised within the last month (adjusted OR = 3.70, 95 % CI 1.22–11.24), appropriate drug prescriptions (adjusted OR = 3.71, 95 % CI 1.38–9.96), regular submission of drug reports (adjusted OR = 4.02, 95 % CI 1.62–10.10) and having a respiratory timer as a diagnostic tool (adjusted OR =3.11, 95 % CI 1.08–9.00). Conclusions: The low medicine stocks for the community management of childhood illnesses calls for strengthening of CHW supervision, medicine prescription and reporting, and increasing availability of functional diagnostic tools.
T-Cell malignancies following CAR T-Cell therapy: insights from the FDA adverse event reporting system (FAERS)
Creators: name: Di Napoli, Raffaella
name: Balzano, Nunzia
name: Ruggiero, Rosanna
name: Mascolo, Annamaria
name: Scavone, Cristina
name: di Mauro, Gabriella
name: Capuano, Annalisa
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: Hematology

description: Concern about post-CAR T-cell lymphomas recently emerged. Analysis of pharmacovigilance data contribute to continuous safety monitoring, especially for newly authorized medicines, like CAR-T therapies. Individual case safety reports (ICSRs) reporting at least one CAR T-cell therapy as a suspect drug were extracted from the Food and Drug Administration Adverse Event Reporting System database up to 6 February 2024. Descriptive and disproportionality analysis were performed. Seventeen ICSRs reported T-cell malignancies associated with CAR T-cell therapy. Gender distribution was similar between females and males, and adult patients accounted for 41.2% of ICSRs. All cases were serious, with 41.2% resulting in death. The most reported Preferred Terms (PTs) for T-cell malignancies was ‘T-cell lymphoma’ (70.6%). Over 70% of ICSRs reported at least one other adverse event, predominantly gastrointestinal disorders (14.3%). Axicabtagene ciloleucel and tisagenlecleucel were associated with a statistically higher reporting frequency of T-cell lymphoma compared to all other drugs (p-value <0.001, for both). Statistically higher reporting frequencies of ‘Haematological malignant tumors’ and ‘Malignant lymphomas’ SMQs emerged when tisagenlecleucel was compared with axicabtagene ciloleucel (p-value <0.001, for both). Axicabtagene ciloleucel and tisagenlecleucel may be associated with a higher reporting frequency of T-cell lymphoma than other drugs.
Language Programs’ Post-pandemic Future in Designing a Sustainable Life
Creators: name: Ferry, Megan M.
Publisher: name: Humanities Commons
Year: 2020
Subjects: subject: Language and languages--Study and teaching
subject: Language and languages--Study and teaching--Methodology

description: Collegiate language programs faced challenges for survival long before COVID-19 hit the US. Now with the impending financial fallout from having to move online, colleges and universities will be scrutinizing even more so the value and viability of supporting language departments. This presentation will present a snapshot of where language programs and departments stand now in this COVID moment, and where we are heading in the future. It considers how department and program leaders can take advantage of this moment to rethink our professional expertise in active learning pedagogies and transcultural competency, which have allowed us to successfully adapt to our new condition. College programs can strengthen a transcultural and multilingual mindset with strong connections across the K-16 setting, thus emphasizing these as essential skills for sustainable life and reaffirming humanist values of justice and inclusion.
title: Language Programs' Post-pandemic Future in Designing a Sustainable Life
title: Language Programs' Post-pandemic Future in Designing a Sustainable Life
titleType: Other
Creators: name: Ferry, Megan M.
Publisher: name: unknown
Year: 2020
Subjects: subject: Language and languages--Study and teaching
subject: Language and languages--Study and teaching--Methodology

description: Collegiate language programs faced challenges for survival long before COVID-19 hit the US. Now with the impending financial fallout from having to move online, colleges and universities will be scrutinizing even more so the value and viability of supporting language departments. This presentation will present a snapshot of where language programs and departments stand now in this COVID moment, and where we are heading in the future. It considers how department and program leaders can take advantage of this moment to rethink our professional expertise in active learning pedagogies and transcultural competency, which have allowed us to successfully adapt to our new condition. College programs can strengthen a transcultural and multilingual mindset with strong connections across the K-16 setting, thus emphasizing these as essential skills for sustainable life and reaffirming humanist values of justice and inclusion.
sj-pdf-1-apy-10.1177_10398562211028646 – Supplemental material for Engagement of mental health service users and carers in care planning – Is it meaningful and adding value?
Creators: name: Scott, Russ
name: Aboud, Andrew
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: Neuroscience

description: Supplemental material, sj-pdf-1-apy-10.1177_10398562211028646 for Engagement of mental health service users and carers in care planning – Is it meaningful and adding value? by Russ Scott and Andrew Aboud in Australasian Psychiatry
Real-world safety evaluation of brivaracetam: insights from the US FDA Adverse Event Reporting System
Creators: name: Meng, Zenan
name: Li, Xinzhi
name: Liao, Yue
name: Feng, Feng
name: Wang, Tingting
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Mental Health

description: Brivaracetam (BRV) is a novel drug for the treatment of epilepsy. This study aimed to detect and characterize adverse events (AEs) associated with BRV from the first quarter of 2016 to the second quarter of 2024 using the U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database. We utilized disproportionality analysis methods, including the reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian confidence propagation neural network (BCPNN), and multi-item gamma Poisson shrinker (MGPS), to assess the associations between reported AEs and BRV usage in the FAERS data. A total of 1,781 adverse event reports were analyzed, with Brivaracetam as the primary suspected drug. We identified 13 positive system organ classes (SOCs) and 78 positive preferred term signals (PTs), with a particular focus on nervous system disorders, psychiatric disorders, and injury, poisoning, and procedural complications. Exposures related to injury, poisoning, and procedural complications during pregnancy and lactation showed positive signals, including exposure before pregnancy, during breastfeeding, and during pregnancy. These exposures warrant significant attention. Based on the FAERS database, we conducted a comprehensive analysis of AEs associated with BRV. This study aims to provide guidance for the clinical application of BRV in epilepsy treatment, thereby improving its safety.
Changes in diabetes care indicators: findings from German National Health Interview and Examination Surveys 1997–1999 and 2008–2011
Creators: name: Du, Yong
name: Heidemann, Christin
name: Rosario, Angelika Schaffrath
name: Buttery, Amanda
name: Paprott, Rebecca
name: Neuhauser, Hannelore
name: Riedel, Thea
name: Icks, Andrea
name: Scheidt-Nave, Christa
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2015
Subjects: subject: 610 Medizin

description: Objectives: To investigate changes in type 2 diabetes care indicators over time in Germany. Methods: Adults aged 45–79 years with type 2 diabetes were identified from two national health examination surveys conducted in 1997–1999 (GNHIES98, n=333) and in 2008–2011 (DEGS1, n=526). We examined diabetes care indicators including treatment and preventive targets (glycemic control, blood pressure (BP), total cholesterol (TC), smoking, weight reduction, sports activity), self-management and care process measures (glucose self-monitoring, holding a diabetes passport, annual foot and eye examination; statin use), and the presence of diabetes-specific complications (diabetic nephropathy, retinopathy, neuropathy, diabetic foot, amputations) and comorbid cardiovascular disease (CVD) or chronic kidney disease (CKD). We calculated proportions of persons meeting these care indicators by survey and examined unadjusted and adjusted changes between surveys. Results: Significant improvement (GNHIES98 vs DEGS1) over time was observed for glycated hemoglobin (HbA1c)
Magnetic Resonance Imaging Guided Neuromodulation of Gastric Physiology
Creators: name: Lu, Kun-Han
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Animal structure and function
Animal physiology - biophysics
Animal physiology - cell
Animal physiology - systems
Digital processor architectures
Other information and computing sciences not elsewhere classified
Neurosciences not elsewhere classified
Radiology and organ imaging

description: The stomach is a digestive organ in the gastrointestinal tract that regulates food intake and paces digestion of nutrients and fluids. The emptying and motility patterns of the stomach are crucial rate-determining processes in maintaining energy homeostasis in the body. Dysregulation of gastric functions often leads to distressing conditions such as gastroesophageal reflux diseases, functional dyspepsia, gastroparesis and obesity. Gastric disorders affect more than 60 million people in the US, producing significant medical and economic burden. These diseases are often chronic and greatly compromise quality of life. As the causes of these diseases remain largely unknown, effects of current pharmacological, dietary, or surgical treatments are often dismal. In this regard, neuromodulation of peripheral nerves emerges as a promising electroceutical therapy for remedying gastric disorders. However, therapeutic effects were shown to be modest, largely due to the inability to validate or calibrate the efficacy and stability of neuromodulation methods with appropriate physiological readouts. To address these problems, here I developed a non-invasive, repeatable online high-resolution magnetic resonance imaging protocol, empowered with advanced image processing algorithms, to track gastric emptying, antral motility, pyloric motility, intestinal filling and absorption in a rat model. The protocol can be used to guide tuning and optimization of stimulation parameters of neuromodulation without perturbing ongoing and spontaneous physiology. The proposed technology and findings are expected to pave the way for the use of gastric MRI to evaluate the efficacy of therapeutics in treating gastric disorders under both preclinical and clinical settings.
Additional file 1 of Differential network connectivity analysis for microbiome data adjusted for clinical covariates using jackknife pseudo-values
Creators: name: Ahn, Seungjun
name: Datta, Somnath
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1. Comparison of computational time of SOHPIE-DNA with that of NetCoMi and MDiNE.
In vitro activity of ceftobiprole against key pathogens associated with pneumonia in hospitalized patients: results from the PEG surveillance study, 2010
Creators: name: Kresken, Michael
name: Körber-Irrgang, Barbara
name: Kaase, Martin
name: Layer, Franziska
name: Pfeifer, Yvonne
name: Werner, Guido
name: Hafner, Dieter
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2015
Subjects: subject: respiratory tract infections
subject: community-acquired pneumonia
subject: CAP
subject: hospital-acquired pneumonia
subject: HAP
subject: 610 Medizin

description: Empirical treatment of hospital-acquired pneumonia (HAP) has increasingly been threatened by methicillin-resistant Staphylococcus aureus (MRSA) and multidrug resistant Gram-negative pathogens. In contrast, empirical treatment of community-acquired pneumonia (CAP) is primarily impeded by antimicrobial-resistant pneumococci. Ceftobiprole, recently approved for the treatment of HAP and CAP in Europe, is active against a broad-spectrum of Gram-positive and Gram-negative pathogens, including MRSA and Pseudomonas aeruginosa. The objective of this study was to evaluate the susceptibility of ceftobiprole among 1,246 S. aureus, Streptococcus pneumoniae, Enterobacteriaceae species and P. aeruginosa isolated from respiratory tract and blood. Isolates were collected in 25 laboratories across Germany, Switzerland and Austria. Minimum inhibitory concentrations (MICs) were determined using the microdilution method according to the standard ISO 20776-1:2006 and interpreted by the European Committee on Antimicrobial Susceptibility Testing (EUCAST) breakpoints. Two-thirds of the isolates were obtained from respiratory specimens and one third from blood. There were 544 intensive care unit (ICU) isolates and 702 non-ICU isolates. The share of MRSA in S. aureus was 16%. Among pneumococci, 18.5% showed reduced susceptibility to penicillin. An extended-spectrum β-lactamase (ESBL) phenotype was confirmed for 18.4% of the Escherichia coli and 16.7% of the Klebsiella pneumoniae isolates. Of the P. aeruginosa isolates, 20.7% were ceftazidime-resistant. MIC50/90 values of ceftobiprole for methicillin-susceptible S. aureus (MSSA) and MRSA were 0.5/0.5 mg/L and 2/2 mg/L, respectively. All pneumococci were inhibited at 1 mg/L ceftobiprole. The activity of ceftobiprole against E. coli and K. pneumoniae was similar to that of ceftriaxone, but ceftobiprole showed superior activity against Enterobacteriaceae species known to produce chromosomally encoded AmpC-β-lactamases. MIC50/90 values of ceftobiprole for ceftazidime-susceptible (4/16 mg/L) and ceftazidime-resistant P. aeruginosa (16/>32 mg/L) were comparable to those of cefepime (4/8 mg/L and 32/>32 mg/L, respectively). These findings suggest that ceftobiprole may represent a suitable option for the empirical treatment of HAP and CAP.