cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Critical parameters from generalised multifractal analysis at the Anderson transition
Creators: name: Rodriguez, Alberto
name: Vasquez, Louella J.
name: Slevin, Keith
name: Römer, Rudolf A.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: We propose a generalization of multifractal analysis that is applicable to the critical regime of the Anderson localization-delocalization transition. The approach reveals that the behavior of the probability distribution of wavefunction amplitudes is sufficient to characterize the transition. In combination with finite-size scaling, this formalism permits the critical parameters to be estimated without the need for conductance or other transport measurements. Applying this method to high-precision data for wavefunction statistics obtained by exact diagonalization of the three-dimensional Anderson model, we estimate the critical exponent $ν=1.58\pm 0.03$.
description: 5 pages, 3 figures, 2 tables
Stromal upregulation of lateral epithelial adhesions: gene expression analysis of signalling pathways in prostate epithelium
Creators: name: Chambers, Karen F.
name: Pearson, Joanna F.
name: Pellacani, Davide
name: Aziz, Naveed
name: Gužvić, Miodrag
name: Klein, Christoph A.
name: Lang, Shona H.
Publisher: name: Universität Regensburg
Year: 2011
Subjects: subject: 610 Medizin

description: In 3D prostate cultures, stromal cells increase lateral epithelial cell adhesions. We show that this morphological effect is associated with gene expression changes to TGF beta signalling, cytoskeleton and anion activity.
The Effect of Carbon-Based Surfaces on the Development and Structure of Marine Cyanobacterial Biofilms
Creators: name: Lima, Marta
Publisher: name: Zenodo
Year: 2023
Subjects: marine biofouling; cyanobacterial biofilms; antifouling surfaces; carbon nanotubes; Optical Coherence Tomography

description: Marine biofouling is a process by which natural and artificial submerged structures are colonized by marine organisms, leading to serious economic, energetic, environmental, and ecological consequences. Since biofilm formation is one of the first steps of this natural process, a potential strategy to delay marine biofouling is to develop novel and environmentally friendly antifouling strategies, such as the manufacture of innovative nanocomposite coatings. Carbon nanotubes (CNTs) have been widely used for several applications due to their outstanding properties, including their mechanical strength, structural stability, and antimicrobial and anti-adhesive activities. However, since there are few studies evaluating the performance of CNTs on marine biofilm formation in long-term assays, furthering knowledge in this field may allow the development of new methodologies to control marine biofouling. 
This work aimed to produce and characterize CNT-based surfaces and evaluate their performance against marine cyanobacterial biofilms. For this purpose, 3% (w/v) CNTs were incorporated into a commercially available epoxy resin, and the resulting composite was used to coat glass surfaces. Both CNT-based and control (glass and glass coated with epoxy resin) surfaces were analyzed by Scanning Electron Microscopy (SEM) and Atomic Force Microscopy (AFM). The effect of CNT-based surfaces on the development and structure of Nodosilinea cf. nodulosa LEGE 10377 biofilms was monitored for 7 weeks under conditions that mimic the hydrodynamics of relevant marine environments. Biofilms were analyzed by Optical Coherence Tomography and SEM.
SEM and AFM showed that, while glass and epoxy resin (controls) were the most homogeneous and smooth surfaces, CNT-based surfaces were the roughest surfaces, presenting agglomerates of CNTs. Biofilm assay results demonstrated that over the 7 weeks, CNT-based surfaces delayed the development of cyanobacterial biofilms compared to control surfaces. Although there were no differences between the surfaces in the initial stage of biofilm formation, significant reductions in the wet weight, thickness, and biovolume of biofilms developed on the CNT-based surfaces compared to controls were observed in the maturation stage. Furthermore, the biofilms formed on the CNT surfaces were smoother and less porous than those formed on glass and epoxy resin surfaces. The higher antifouling activity of the produced carbon surfaces in the maturation stage may be related to the presence of CNT agglomerates that have a piercing effect on the cells' membrane of the initial biofilm layers. Overall, the incorporation of carbon nanotubes into polymeric matrices showed to be a promising approach to delaying cyanobacterial biofilm development under the marine environmental conditions mimicked in this work.
Endothelin enhances the contractile responsiveness of adult rat ventricular myocytes to calcium by a pertussis toxin-sensitive pathway
Creators: name: Kelly, R. A.
name: Eid, H.
name: Krämer, Bernhard K.
name: O'Neill, M.
name: Liang, B. T.
name: Reers, M.
name: Smith, T. W.
Publisher: name: Universität Regensburg
Year: 1990
Subjects: subject: 610 Medizin
subject: Animals
subject: Calcium/physiology
subject: Endothelins/pharmacology
subject: Endothelium/physiology
subject: GTP-Binding Proteins/physiology
subject: Isoproterenol/pharmacology
subject: Myocardial Contraction/drug effects
subject: Pertussis Toxin
subject: Rats
subject: Verapamil/pharmacology
subject: Virulence Factors, Bordetella/pharmacology

description: It has long been assumed that the primary influences regulating cardiac contractility are the extent of mechanical loading of muscle fibers and the activity of the autonomic nervous system. However, the vasoactive peptide endothelin, initially found in vascular endothelium, is among the most potent positively inotropic agents yet described in mammalian myocardium. In isolated adult rat ventricular cells, endothelin's action was slow in onset but very long lasting with an EC50 of 50 pM that approximates the reported KD of the peptide for its receptor in rat heart. When the calcium activity of the buffer superfusing isolated single fura-2-loaded myocytes paced at 1.5 Hz was varied from 0.1 to 0.9 mM [Ca2+]o, 100 pM endothelin increased contractile amplitude with no significant change in diastolic or systolic [Ca2+]i, thus appearing to sensitize the myofilaments to intracellular calcium. Pertussis toxin, or prior exposure to a beta-adrenergic agonist, reduced or abolished the increase in myocyte contractility induced by endothelin. This novel and potent pharmacologic action of endothelin points to the potential importance of local, paracrine factors, perhaps derived from microvascular endothelium or endocardium, in the control of the contractile function of the heart.
description: Erratum in: J Clin Invest 1991 Apr;87(4):following 1477
Connection between rotation and miscibility in a two-component Bose-Einstein condensate
Creators: name: Shimodaira, Takayuki
name: Kishimoto, Tetsuo
name: Saito, Hiroki
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: A two-component Bose-Einstein condensate rotating in a toroidal trap is investigated. The topological constraint depends on the density distribution of each component along the circumference of the torus, and therefore the quantization condition on the circulation can be controlled by changing the miscibility using the Feshbach resonance. We find that the system exhibits a variety of dynamics depending on the initial angular momentum when the miscibility is changed.
description: 6 pages, 7 figures
Systemic epidermal nevus with involvement of the oral mucosa due to FGFR3 mutation
Creators: name: Bygum, Anette
name: Fagerberg, Christina R.
name: Clemmensen, Ole J.
name: Fiebig, Britta
name: Hafner, Christian
Publisher: name: Universität Regensburg
Year: 2011
Subjects: subject: 610 Medizin
subject: Epidermis/pathology
subject: Female
subject: Humans
subject: Mosaicism
subject: Mouth Mucosa/pathology
subject: Mutation, Missense/genetics
subject: Nevus/genetics
subject: Receptor, Fibroblast Growth Factor, Type 3/genetics

description: Our results show that activating FGFR3 mutations can also affect the oral mucosa and that extracutaneous manifestations of EN syndrome can be subtle. We highlight the theoretical risk of the patient having an offspring with thanatophoric dysplasia as gonadal mosaicism for the R248C mutation cannot be excluded.
B-meson physics from non-perturbative lattice heavy quark effective theory
Creators: name: Garron, Nicolas
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: During the last years, the ALPHA collaboration has been developing and implementing a method based on Heavy Quark Effective Theory (HQET) to compute B-mesons observables through lattice simulations. Thanks to a non-perturbative matching to QCD, the theory is renormalizable at any order of the heavy quark mass expansion. In order to extract precisely the relevant matrix elements and masses, we use all-to-all propagators and solve an generalized eigenvalue problem (GEVP). We have shown in the quenched approximation that quantities like the b-quark mass mb, the heavy-light decay constant(s) or the B-meson spectrum can be computed precisely beyond the static approximation (including the first corrections in 1/\mb). More recently, we have started to include the sea quark effects, by working with Nf=2 light flavors of dynamical fermions[1]. The computation of the matching parameters is almost finished, but concerning the extraction of the hadronic quantities for which we use some CLS ensembles[2], only one lattice spacing has been analyzed so far. In this proceeding we report on the status of this project and present some preliminary results.
description: 4 pages, 1 figure. Contribution to ICHEP 2010, July 22 - 28, 2010, Paris
Hybrid Calculus of Wrapped Compartments
Creators: name: Coppo, Mario
name: Damiani, Ferruccio
name: Drocco, Maurizio
name: Grassi, Elena
name: Sciacca, Eva
name: Spinella, Salvatore
name: Troina, Angelo
Publisher: name: arXiv
Year: 2010
Subjects: subject: Programming Languages (cs.PL)
subject: Computational Engineering, Finance, and Science (cs.CE)
subject: Quantitative Methods (q-bio.QM)
subject: FOS: Computer and information sciences
subject: FOS: Biological sciences
subject: D.3.1 ; D.3.3 ; F.3.2 ; G.1.7 ; G.3 ; I.6.8 ; J.3

description: The modelling and analysis of biological systems has deep roots in Mathematics, specifically in the field of ordinary differential equations (ODEs). Alternative approaches based on formal calculi, often derived from process algebras or term rewriting systems, provide a quite complementary way to analyze the behaviour of biological systems. These calculi allow to cope in a natural way with notions like compartments and membranes, which are not easy (sometimes impossible) to handle with purely numerical approaches, and are often based on stochastic simulation methods. Recently, it has also become evident that stochastic effects in regulatory networks play a crucial role in the analysis of such systems. Actually, in many situations it is necessary to use stochastic models. For example when the system to be described is based on the interaction of few molecules, when we are at the presence of a chemical instability, or when we want to simulate the functioning of a pool of entities whose compartmentalised structure evolves dynamically. In contrast, stable metabolic networks, involving a large number of reagents, for which the computational cost of a stochastic simulation becomes an insurmountable obstacle, are efficiently modelled with ODEs. In this paper we define a hybrid simulation method, combining the stochastic approach with ODEs, for systems described in CWC, a calculus on which we can express the compartmentalisation of a biological system whose evolution is defined by a set of rewrite rules.
description: In Proceedings MeCBIC 2010, arXiv:1011.0051
title: Mechanotendography: description and evaluation of a novel method for investigating the physiological mechanical oscillations of tendons using a piezo-based measurement system
Creators: name: Schaefer, Laura V.
name: Bittmann, Frank N.
Publisher: name: Universität Potsdam
Year: 2022
Subjects: subject: 610 Medizin und Gesundheit

description: The mechanotendography (MTG) is a method for analyzing the mechanical oscillations of tendons during muscular actions. The aim of this investigation was to evaluate the technical reliability of a piezo-based measurement system used for MTG. The reliability measurements were performed by using audio samples played by a subwoofer. The thereby generated pressure waves were recorded by a piezo-based measurement system. An audio of 40 Hz sine oscillations and four different formerly in vivo recorded MTG-signals were converted into audio files and were used as test signals. Five trials with each audio were performed and one audio was used for repetition trials on another day. The signals’ correlation was estimated by Spearman (MCC) and intraclass correlation coefficients (ICC(3,1)), Cronbach’s alpha (CA) and by mean distances (MD). All parameters were compared between repetition and randomized matched signals. The repetition trials show high correlations (MCC: 0.86 ± 0.13, ICC: 0.89 ± 0.12, CA: 0.98 ± 0.03), low MD (0.03 ± 0.03V) and differ significantly from the randomized matched signals (MCC: 0.15 ± 0.10, ICC: 0.17 ± 0.09, CA: 0.37 ± 0.16, MD: 0.19 ± 0.01V) (p = 0.001 – 0.043). This speaks for an excellent reliability of the measurement system. Presuming the skin above superficial tendons oscillates adequately, we estimate this tool as valid for the application in musculoskeletal system.
description: Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe; 737
Understanding tumor heterogeneity as functional compartments--superorganisms revisited
Creators: name: Grunewald, Thomas G. P.
name: Herbst, Saskia M.
name: Heinze, Jürgen
name: Burdach, Stefan
Publisher: name: Universität Regensburg
Year: 2011
Subjects: subject: 610 Medizin
subject: Animals
subject: Clone Cells
subject: Genetic Heterogeneity
subject: Humans
subject: Immunologic Surveillance
subject: Insects/physiology
subject: Neoplasms/pathology
subject: Neovascularization, Pathologic/pathology

description: Compelling evidence broadens our understanding of tumors as highly heterogeneous populations derived from one common progenitor. In this review we portray various stages of tumorigenesis, tumor progression, self-seeding and metastasis in analogy to the superorganisms of insect societies to exemplify the highly complex architecture of a neoplasm as a system of functional "castes."Accordingly, we propose a model in which clonal expansion and cumulative acquisition of genetic alterations produce tumor compartments each equipped with distinct traits and thus distinct functions that cooperate to establish clinically apparent tumors. This functional compartment model also suggests mechanisms for the self-construction of tumor stem cell niches. Thus, thinking of a tumor as a superorganism will provide systemic insight into its functional compartmentalization and may even have clinical implications.
Proteinurie und atherogenes Risiko [Proteinuria and atherogenic risk]
Creators: name: Strutz, F.
name: Lueg, H. O.
name: Risler, T.
name: Erley, C. M.
name: Estler, M.
name: Krämer, Bernhard K.
name: Müller, G. A.
Publisher: name: Universität Regensburg
Year: 1992
Subjects: subject: 610 Medizin
subject: Adult
subject: Arteriosclerosis/etiology
subject: Cholesterol/blood
subject: Cholesterol, HDL/blood
subject: Cholesterol, LDL/blood
subject: Creatinine/blood
subject: Female
subject: Glomerulonephritis/complications
subject: Humans
subject: Male
subject: Middle Aged
subject: Proteinuria/complications
subject: Retrospective Studies
subject: Risk Factors
subject: Triglycerides/blood

description: The relationship between blood-lipid levels and severity of proteinuria was examined retrospectively in 30 patients (12 males, 18 females; mean age 39 [18-58] years). All patients had histologically confirmed glomerulonephritis (minimal change: n = 7, perimembranous: n = 8, focal sclerosing: n = 6, rapid progressive: n = 3, mesangio-proliferative: n = 4, membrano-proliferative: n = 1, diabetic glomerulosclerosis: n = 1). None was taking lipid-lowering drugs. Patients were classified according to the degree of proteinuria. In group 1 (proteinuria less than 5 g/d, n = 13) the LDL-HDL ratio averaged 4.4; in group 2 (proteinuria 5.0-10.0 g/d, n = 10) the average ratio was 8.8, and in group 3 (proteinuria greater than 10.0 g/d, n = 7) 13.3. Total cholesterol concentration also rose with increasing proteinuria (to 300 +/- 87 mg/dl, 375 +/- 168 mg/dl and 464 +/- 143 mg/d, respectively). The size of the LDL-HDL ratio and the level of total cholesterol did not correlate with the degree of excretory renal failure. These results point to an impressive correlation between the degree of proteinuria and the level of LDL-HDL ratio as a measure of atherogenic risk for a given patient.
Attack Forecast and Prediction
Creators: name: Kaiser, Florian
name: Budig, Tobias
name: Goebel, Elisabeth
name: Fischer, Tessa
name: Muff, Jurek
name: Wiens, Marcus
name: Schultmann, Frank
Publisher: name: CEUR-WS.org
Year: 2021
Subjects: Attack Prediction
Cyber Threat Intelligence
Genetic Algorithms

description: Cyber-security has emerged as one of the most pressing issues for society with actors trying to use offensive capabilities and those who try to leverage on defensive capabilities to secure their assets or knowledge. However, in cyber-space attackers oftentimes have a significant first mover advantage leading to a dynamic cat and mouse game with defenders. Cyber Threat Intelligence (CTI) on past attacks bears potentials that can be used by means of predictive analytics to minimize the attackers first mover advantage. Yet, attack prediction is not an established means and automation levels are low. Within this work, we present Attack Forecast and Prediction (𝐴𝐹 𝑃) which is based on MITRE Adversarial Tactics, Techniques and Common Knowledge (ATT&CK). 𝐴𝐹 𝑃 consists of three modules representing different analytical procedures which are clustering, time series analysis, and genetic algorithms. 𝐴𝐹 𝑃 identifies trends in the usage of attack techniques and crafts forecasts and predictions on future malware and the attack techniques used. We rely on time sorting to generate subgraphs of MITRE ATT&CK and evaluate the accuracy of predictions generated by 𝐴𝐹 𝑃 based on these. Results of an experiment performed on the basis of 493 different malware, validate the utility of using 𝐴𝐹 𝑃 for attack prediction. 𝐴𝐹 𝑃 reaches for each module an F-score which is higher than an extrapolation of observed probabilities (baseline) with an F-score of up to 0.83 for a single module. It can hence be considered an effective means for predicting future attack patterns and help security professionals with preparing for future attacks.
Schwerer Verlauf einer Leptospirose mit akutem Nierenversagen und ausgeprägtem Ikterus (Morbus Weil) [A severe course of leptospirosis with acute kidney failure and extensive icterus (Weil disease)]
Creators: name: Notheis, W. F.
name: Krämer, Bernhard K.
name: Leser, H. G.
name: Rüschoff, J.
name: Kromer, E. P.
name: Riegger, G. A. J.
Publisher: name: Universität Regensburg
Year: 1993
Subjects: subject: 610 Medizin
subject: Acute Kidney Injury/therapy
subject: Aged
subject: Biopsy, Needle
subject: Humans
subject: Jaundice/etiology
subject: Liver/pathology
subject: Male
subject: Penicillin G/administration & dosage
subject: Prognosis
subject: Renal Dialysis
subject: Weil Disease/drug therapy

description: A 77-year-old man developed a fever up to 38.4 degrees C, with diarrhoea, acute renal failure (creatinine up to 8.7 mg/dl; urea up to 308 mg/dl) and marked jaundice (total bilirubin up to 24.3 mg/dl). In addition there was thrombocytopenia, conjunctivitis and epistaxis, as well as cerebral symptoms with somnolence and general slowing up. At first he was thought to have cholangitis resulting from previously diagnosed gall-stones, and he was therefore treated with ampicillin, 2 g two times daily, and metronidazole, 0.5 g two times daily. The fewer regressed, but the renal failure required haemodialysis and haemofiltration under strict fluid control. Endoscopy excluded obstructive jaundice, but a suspicion of inflammatory liver disease or possibly cirrhosis was raised in the differential diagnosis. Serology revealed an increased titre for Leptospira interrogans var. sejroe (1:200, later 1:1600). Liver biopsy finding was compatible with the diagnosis of leptospirosis. Because of the high inflammatory activity in the liver, 2 mega units of penicillin G were administered three times daily for six days. Gradually the renal functions and jaundice improved and, on discharge on the 36th day, the patient was again in generally good health, although creatinine and bilirubin values were still slightly elevated (1.7 mg/dl each).
Deep mining of massive stars in TESS
Creators: name: Barbá, Rodolfo
name: GOSSS Collaboration
Publisher: name: Zenodo
Year: 2021
Subjects: binaries: close
binaries: eclipsing
stars: massive
stars: variables

description: We are producing the most complete catalogs of massive stars, namely: GOSSS for O-type stars, B-SUGOS for B-type supergiants, and SUGUS-AM for A to M stars. Using those catalogues, we started a deep mining of TESS images extracting hundreds of light-curves to discover eclipsing systems. In this talk, I wish to present the zoo of light curves, highlighting some special cases.
Noise and Neuronal Heterogeneity
Creators: name: Barber, Michael J.
name: Ristig, Manfred L.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Neurons and Cognition (q-bio.NC)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: We consider signal transaction in a simple neuronal model featuring intrinsic noise. The presence of noise limits the precision of neural responses and impacts the quality of neural signal transduction. We assess the signal transduction quality in relation to the level of noise, and show it to be maximized by a non-zero level of noise, analogous to the stochastic resonance effect. The quality enhancement occurs for a finite range of stimuli to a single neuron; we show how to construct networks of neurons that extend the range. The range increases more rapidly with network size when we make use of heterogeneous populations of neurons with a variety of thresholds, rather than homogeneous populations of neurons all with the same threshold. The limited precision of neural responses thus can have a direct effect on the optimal network structure, with diverse functional properties of the constituent neurons supporting an economical information processing strategy that reduces the metabolic costs of handling a broad class of stimuli.
description: 17 pages, 9 figures
MCCULLOCH VS. MARYLAND (1819)
Creators: name: Nieto Olvera, Pedro David
Publisher: name: SenArchive
Year: 2023
Subjects: MCCULLOCH
MARYLAND
constitucional
Corte Suprema de EEUU

description: El caso judicial conocido como McCulloch v. Maryland[1], del 6 de marzo de 1819, fue un caso trascendental de la Corte Suprema de EEUU, pues afirmó el derecho de los poderes implícitos, es decir, que había poderes que tenía el gobierno federal que no se mencionaban explícitamente en la Constitución, pero que estaban incluídos. Además, la Corte Suprema determinó que los Estados no pueden hacer leyes que interfieran con las leyes del Congreso permitidas por la Constitución. Las preguntas clave fueron: ¿Tenía el Congreso la autoridad para constituir el Banco? y, ¿al imponer impuestos sobre el Banco, el Estado de Maryland estaba actuando fuera de la Constitución? El Tribunal sostuvo que el Congreso tenía el poder de incorporar un Banco y que el Estado de Maryland no podía gravar los instrumentos del gobierno nacional empleados en la ejecución de los poderes constitucionales.
 
[1] McCulloch v. Maryland, 17 U.S. 316 (1819), https://supreme.justia.com/cases/federal/us/17/316/#tab-opinion-1918127
Advancement and calibration of a 3D numerical model for landslide runout analysis
Creators: name: Aaron, Jordan Balfour
Publisher: name: University of British Columbia
Year: 2017

description: Rapid landslides pose a significant hazard worldwide, and there is currently no routine way of predicting the impact area and velocities of these catastrophic events. Increased development in marginal areas is changing the landslide risk in many parts of the world. There is an urgent need for practical methods to predict the motion of these tragic events to cope with this changing risk. Practical methods currently in use rely on simplified landslide statistics that have a high degree of uncertainty, and are often unable to predict landslide velocities. The focus of this thesis is on developing practical methods to reliably predict the motion of rapid landslides so that public safety in landslide prone areas can be improved. This thesis makes extensive use of runout modelling in order to analyse the motion of rock avalanches, debris avalanches and flowslides. The work presented here can be broadly divided into two categories; the development of new tools and techniques to model flow-like landslide motion, and the compilation and analysis of a database of case histories. The new tools include: 1) A new rheology appropriate for the simulation of liquefied materials; 2) A new dynamic model to simulate the initially-coherent motion of some rock and debris avalanches; 3) Two new calibration methodologies. These techniques were then applied to a database of rock avalanches, debris avalanches and flowslide case histories in order to infer movement mechanisms and give guidance for forward prediction. The main findings include: 1) The character of the path materials is a plausible explanation for the mechanism governing rock avalanche motion. Based on this, a probabilistic framework to predict rock avalanche motion was suggested; 2) A back-analysis of a fatal debris avalanche that occurred in British Columbia in 2012 revealed that this flow was likely moving in an undrained condition, which had significant implications for the analysis of its motion; 3) It was found that flowslides can occur in fine grained colluvium, and this material should be recognized as potentially liquefiable.
Clarifying misconception of quality and safety in healthcare
Creators: name: CHATZI, ANNA
name: Kourousis, Kyriakos I.
Publisher: name: University of Limerick
Year: 2024
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 40
subject: Engineering

description: Purpose – Healthcare has undergone multiple phases in gaining understanding, accepting and implementing quality and safety, with the last 3 decades being crucial and decisive in making progress. During that time, safety has always been quoted along with quality, but the cost of error in healthcare (both in human lives and monetary cost) has been continuing to rise. Design/methodology/approach – This article discusses the authors’ expert perspective in comparison to the industry’s research and practice outputs. Findings – Healthcare has not yet defined quality and safety. This is allowing the misconception that already established quality management systems (QMSs) are fit for safety purposes as well. Even though aviation has acted as a paradigm for healthcare, further alignment in embedding safety management systems (SMS) has yet to be realised. Originality/value – In this paper, the distinct nature of safety and its detachment of quality is being discussed, along with the need for clear and safety specific processes. Setting common language is the first step in establishing appropriate safety processes within SMSs, operating in tandem with QMSs, to promote patient safety successfully.
Spectral estimation at the edge
Creators: name: Patel, Shivangi
name: Psarou, Eleni
name: Mönke, Gregor
name: Fries, Pascal
Publisher: name: Zenodo
Year: 2025
Subjects: phase estimation
Neuroscience
Brain rhythms
spectral estimation

description: This repository contains the code for the phase estimation method developed and presented in Patel et al., Spectral Estimation at the Edge. It also includes implementations of previously established methods and their comparisons to AR Fourier, our proposed method, using both simulated and empirical datasets.
Towards Matter Inflation in Heterotic String Theory
Creators: name: Antusch, Stefan
name: Dutta, Koushik
name: Erdmenger, Johanna
name: Halter, Sebastian
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Recently, a class of inflation models in supergravity with gauge non-singlet matter fields as the inflaton has been proposed. It is based on a `tribrid' structure in the superpotential and on a Heisenberg symmetry for solving the eta-problem. We suggest that a generalization of this model class may be suitable for realising inflation in heterotic orbifold compactifications, where the Heisenberg symmetry is a property of the tree-level K"ahler potential of untwisted matter fields. We discuss moduli stabilization in this setup and propose a mechanism to stabilize the modulus associated to the inflaton, which respects the symmetry in the large radius limit. Inflation ends via a waterfall phase transition, as in hybrid inflation. We give conditions which have to be satisfied for realising inflation along these lines in the matter sector of heterotic orbifolds.
description: PDFLaTeX, 41 pages, 7 PDF figures
Photoexcitation of valley-orbit currents in (111)-oriented silicon metal-oxide-semiconductor field-effect transistors
Creators: name: Karch, J.
name: Tarasenko, S. A.
name: Ivchenko, E. L.
name: Kamann, J.
name: Olbrich, P.
name: Utz, M.
name: Kvon, Z. D.
name: Ganichev, S. D.
Publisher: name: Universität Regensburg
Year: 2011
Subjects: subject: 530 Physik
subject: 78.40.Fy, 72.40.+w, 73.40.Qv, 78.20.−e

description: We demonstrate the injection of pure valley-orbit currents in multivalley semiconductors and present the phenomenological theory of this effect. We studied photoinduced transport in (111)-oriented silicon metaloxide-semiconductor ﬁeld effect transistors at room temperature. By shining circularly polarized light on exact oriented structures with six equivalent valleys, nonzero electron ﬂuxes within each valley are generated, which compensate each other and do not yield a net electric current. By disturbing the balance between the valley ﬂuxes, we demonstrate that the pure valley-orbit currents can be converted into a measurable electric current.
Towards Antihydrogen Trapping and Spectroscopy at ALPHA
Creators: name: Butler, Eoin
name: Andresen, Gorm. B.
name: Ashkezari, Mohammad. D.
name: Baquero-Ruiz, Marcelo
name: Bertsche, William
name: Bowe, Paul D.
name: Bray, Crystal C.
name: Cesar, Claudio L.
name: Chapman, Steven
name: Charlton, Michael
name: Fajans, Joel
name: Friesen, Tim
name: Fujiwara, Makoto C.
name: Gill, David R.
name: Hangst, Jeffrey S.
name: Hardy, Walter N.
name: Hayano, Ruyugo S.
name: Hayden, Michael E.
name: Humphries, Andrew J.
name: Hydomako, Richard
name: Jonsell, Svante
name: Kurchaninov, Leonid
name: Lambo, Ricardo
name: Madsen, Niels
name: Menary, Scott
name: Nolan, Paul
name: Olchanski, Konstantin
name: Olin, Art
name: Povilus, Alexander
name: Pusa, Petteri
name: Robicheaux, Francis
name: Sarid, Eli
name: Silveira, Daniel M.
name: So, Chukman
name: Storey, James W.
name: Thompson, Robert I.
name: van der Werf, Dirk P.
name: Wilding, Dean
name: Wurtele, Jonathan S.
name: Yamazaki, Yasunori
Publisher: name: arXiv
Year: 2011
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: Spectroscopy of antihydrogen has the potential to yield high-precision tests of the CPT theorem and shed light on the matter-antimatter imbalance in the Universe. The ALPHA antihydrogen trap at CERN's Antiproton Decelerator aims to prepare a sample of antihydrogen atoms confined in an octupole-based Ioffe trap and to measure the frequency of several atomic transitions. We describe our techniques to directly measure the antiproton temperature and a new technique to cool them to below 10 K. We also show how our unique position-sensitive annihilation detector provides us with a highly sensitive method of identifying antiproton annihilations and effectively rejecting the cosmic-ray background.
description: 10 pages, 5 figures
Development of input connections in neural cultures
Creators: name: Soriano, Jordi
name: Martinez, Maria Rodrriguez
name: Tlusty, Tsvi
name: Moses, Elisha
Publisher: name: arXiv
Year: 2010
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Neurons and Cognition (q-bio.NC)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: We introduce a novel approach for the quantitative assessment of the connectivity in neuronal cultures, based on the statistical mechanics of percolation on a graph. This allows us to follow the development of the culture and see the emergence of connectivity in the network. The culture becomes fully connected at a time equivalent to full term. The spontaneous bursting activity that characterizes cultures develops in parallel with the connectivity. The average number of inputs per neuron can be quantitatively determined in units of $m_0$, the number of activated inputs needed to excite the neuron. For $m_0\sim 10$ we find that hippocampal neurons have on average $\sim 40-80$ inputs while cortical neurons have $\sim 50-100$, depending on neuronal density. The ratio of excitatory to inhibitory neurons is determined using the GABA$_\text{A}$ antagonist bicuculine. This ratio changes during development and reaches the final value at day $7-8$, coinciding with the expected time of the GABA switch. For hippocampal cultures the inhibitory cells comprise about $30\%$ of the neurons in the culture while for cortical cultures they are about $20\%$. Such detailed global information on the connectivity of networks in neuronal cultures is at present inaccessible by any electrophysiological or other technique.
description: Neural cultures | Percolation | Development | Network connectivity http://www.weizmann.ac.il/complex/tlusty/papers/PNAS2008c.pdf
Proximity Induced Enhancement of the Curie Temperature in Hybrid Spin Injection Devices
Creators: name: Song, Cheng
name: Sperl, Matthias
name: Utz, Martin
name: Ciorga, Mariusz
name: Woltersdorf, Georg
name: Schuh, Dieter
name: Bougeard, Dominique
name: Back, Christian
name: Weiss, Dieter
Publisher: name: Universität Regensburg
Year: 2011
Subjects: subject: 530 Physik
subject: 72.25.-b, 75.30.Et, 75.50.Pp, 85.75.-d

description: We investigate the increase of the Curie temperature TC in a lateral spin injection geometry where the ferromagnetic (Ga,Mn)As injector and detector contacts are capped by a thin iron film. Because of interlayer coupling between Fe and (Ga,Mn)As TC gets enhanced by nearly 100% for the thinnest (Ga,Mn)As films. The use of the proximity effect might pave the way for practical implementation of spintronic devices.
Edge- and Node-Disjoint Paths in P Systems
Creators: name: Dinneen, Michael J.
name: Kim, Yun-Bum
name: Nicolescu, Radu
Publisher: name: arXiv
Year: 2010
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: Data Structures and Algorithms (cs.DS)
subject: FOS: Computer and information sciences

description: In this paper, we continue our development of algorithms used for topological network discovery. We present native P system versions of two fundamental problems in graph theory: finding the maximum number of edge- and node-disjoint paths between a source node and target node. We start from the standard depth-first-search maximum flow algorithms, but our approach is totally distributed, when initially no structural information is available and each P system cell has to even learn its immediate neighbors. For the node-disjoint version, our P system rules are designed to enforce node weight capacities (of one), in addition to edge capacities (of one), which are not readily available in the standard network flow algorithms.
description: In Proceedings MeCBIC 2010, arXiv:1011.0051
Periodic quantum mechanical simulation of the He-MgO(100) interaction potential
Creators: name: Martinez-Casado, R.
name: Mallia, G.
name: Usvyat, Denis
name: Maschio, L.
name: Casassa, S.
name: Schütz, Martin
name: Harrison, N. M.
Publisher: name: Universität Regensburg
Year: 2011
Subjects: subject: ab initio calculations; adsorption; ground states; helium; HF calculations; magnesium compounds; surface potential; surface structure;
subject: 540 Chemie
subject: 68.35.B-
subject: 68.43.Bc
subject: 68.43.Mn

description: He-atom scattering is a well established and valuable tool for investigating surface structure. The correct interpretation of the experimental data requires an accurate description of the He-surface interaction potential. A quantum-mechanical treatment of the interaction potential is presented using the current dominant methodologies for computing ground state energies (Hartree–Fock, local and hybrid-exchange density functional theory) and also a novel post-Hartree–Fock ab initio technique for periodic systems (a local implementation of Møller–Plesset perturbation theory at second order). The predicted adsorption well depth and long range behavior of the interaction are compared with that deduced from experimental data in order to assess the accuracy of the interaction potential.
On Decidable Growth-Rate Properties of Imperative Programs
Creators: name: Ben-Amram, Amir M.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Logic in Computer Science (cs.LO)
subject: Programming Languages (cs.PL)
subject: FOS: Computer and information sciences
subject: D.2.4; F.2.0; F.3.1

description: In 2008, Ben-Amram, Jones and Kristiansen showed that for a simple "core" programming language - an imperative language with bounded loops, and arithmetics limited to addition and multiplication - it was possible to decide precisely whether a program had certain growth-rate properties, namely polynomial (or linear) bounds on computed values, or on the running time. This work emphasized the role of the core language in mitigating the notorious undecidability of program properties, so that one deals with decidable problems. A natural and intriguing problem was whether more elements can be added to the core language, improving its utility, while keeping the growth-rate properties decidable. In particular, the method presented could not handle a command that resets a variable to zero. This paper shows how to handle resets. The analysis is given in a logical style (proof rules), and its complexity is shown to be PSPACE-complete (in contrast, without resets, the problem was PTIME). The analysis algorithm evolved from the previous solution in an interesting way: focus was shifted from proving a bound to disproving it, and the algorithm works top-down rather than bottom-up.
Entropy and enthalpy convergence of hydrophobic solvation beyond the hard-sphere limit
Creators: name: Sedlmeier, Felix
name: Horinek, Dominik
name: Netz, Roland R.
Publisher: name: Universität Regensburg
Year: 2011
Subjects: subject: biochemistry; biothermics; convergence; enthalpy; entropy; hydrophobicity; molecular biophysics; potential energy surfaces; proteins; solvation; water
subject: 540 Chemie
subject: 87.15.R-
subject: 82.60.Lf
subject: 82.30.Nr
subject: 82.20.Kh
subject: 68.08.Bc
subject: 87.19.Pp

description: The experimentally well-known convergence of solvation entropies and enthalpies of different small hydrophobic solutes at universal temperatures seems to indicate that hydrophobic solvation is dominated by universal water features and not so much by solute specifics. The reported convergence of the denaturing entropy of a group of different proteins at roughly the same temperature as hydrophobic solutes was consequently argued to indicate that the denaturing entropy of proteins is dominated by the hydrophobic effect and used to estimate the hydrophobic contribution to protein stability. However, this appealing picture was subsequently questioned since the initially claimed universal convergence of denaturing entropies holds only for a small subset of proteins; for a larger data collection no convergence is seen. We report extensive simulation results for the solvation of small spherical solutes in explicit water with varying solute-water potentials. We show that convergence of solvation properties for solutes of different radii exists but that the convergence temperatures depend sensitively on solute-water potential features such as stiffness of the repulsive part and attraction strength, not so much on the attraction range. Accordingly, convergence of solvation properties is only expected for solutes of a homologous series that differ in the number of one species of subunits (which attests to the additivity of solvation properties) or solutes that are characterized by similar solute–water interaction potentials. In contrast, for peptides that arguably consist of multiple groups with widely disperse interactions with water, it means that thermodynamic convergence at a universal temperature cannot be expected, in general, in agreement with experimental results.
Requirements of Vertical Handoff Mechanism in 4G Wireless Networks
Creators: name: Gondara, Mandeep Kaur
name: Kadam, Sanjay
Publisher: name: arXiv
Year: 2011
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: The importance of wireless communication is increasing day by day throughout the world due to cellular and broadband technologies. Everyone around the world would like to be connected seamlessly anytime anywhere through the best network. The 4G wireless system must have the capability to provide high data transfer rates, quality of services and seamless mobility. In 4G, there are a large variety of heterogeneous networks. The users for variety of applications would like to utilize heterogeneous networks on the basis of their preferences such as real time, high availability and high bandwidth. When connections have to switch between heterogeneous networks for performance and high availability reasons, seamless vertical handoff is necessary. The requirements like capability of the network, handoff latency, network cost, network conditions, power consumption and user's preferences must be taken into consideration during vertical handoff. In this paper, we have extracted the requirements of a vertical handoff from the literature surveyed. The evaluation of the existing work is also being done on the basis of required parameters for vertical handoff. A sophisticated, adaptive and intelligent approach is required to implement the vertical handoff mechanism in 4G wireless networks to produce an effective service for the user by considering dynamic and non dynamic parameters.
description: 10 pages,1 figure,2 tables
Planning street transit stops under uncertainties : a fuzzy logic approach
Creators: name: Masood, Hassaan
Publisher: name: University of British Columbia
Year: 2017

description: This research concerns with the effect of street transit stop-related factors on transit demand attraction. Key stop-related factors that influence passengers’ perception of the service were identified along with their recommended standards. It was shown that current transit planning manuals and guidelines suffer from the following limitations: (a) they are silent regarding the relative importance of stop-related factors; (b) they exhibit great deal of variability in service planning standards; and (c) they fail to provide specific standards for different city sizes. The number of factors and variability in service planning standards involved in transit stop planning make it almost impossible for transit planners to decide on the location, interspacing, and design of street transit stops based merely on intuition and experience. Further, classical decision-making approaches, while useful, do not adequately consider the site-specific conditions and uncertainties associated with service standards. To address the above issues, this research adopted a twofold approach. First, an expert opinion survey was conducted among a panel of transit experts across Canada to (a) understand the relative importance of various transit stop-related factors with respect to their attractiveness to passengers; and (b) collect best-practices used in the transit industry to select typical standards for those factors. Second, an index-based decision-support tool was developed through the solicitation and synthesis of experts’ opinions using Analytical Hierarchical Process and Fuzzy Synthetic Evaluation. The developed index-based tool provides a simple way to quantitatively evaluate transit stops, based on a single score (or rating index), considering various factors that affect transit ridership. The developed tool is intended to help transit planners make informed decisions regarding the location, interspacing, and design of existing/new street transit stops. The results showed that, among all spatial (i.e. stop location and interspacing) factors, land use is the most important factor that influences demand attraction, while the most important design factor is real-time information provision. Furthermore, the dataset showed that a lower passenger demand is required in small cities to provide a particular amenity (e.g. seat, shelter, or CCTV camera) at the stop compared to the demand required in large cities to provide the same amenity.
Lumpability Abstractions of Rule-based Systems
Creators: name: Feret, Jerome
name: Henzinger, Thomas
name: Koeppl, Heinz
name: Petrov, Tatjana
Publisher: name: arXiv
Year: 2010
Subjects: subject: Computational Engineering, Finance, and Science (cs.CE)
subject: FOS: Computer and information sciences

description: The induction of a signaling pathway is characterized by transient complex formation and mutual posttranslational modification of proteins. To faithfully capture this combinatorial process in a mathematical model is an important challenge in systems biology. Exploiting the limited context on which most binding and modification events are conditioned, attempts have been made to reduce the combinatorial complexity by quotienting the reachable set of molecular species, into species aggregates while preserving the deterministic semantics of the thermodynamic limit. Recently we proposed a quotienting that also preserves the stochastic semantics and that is complete in the sense that the semantics of individual species can be recovered from the aggregate semantics. In this paper we prove that this quotienting yields a sufficient condition for weak lumpability and that it gives rise to a backward Markov bisimulation between the original and aggregated transition system. We illustrate the framework on a case study of the EGF/insulin receptor crosstalk.
description: In Proceedings MeCBIC 2010, arXiv:1011.0051