cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Hemiptarsenus ornatus Nees
Creators: name: Yefremova, Zoya A.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Eulophidae
Hemiptarsenus
Hemiptarsenus ornatus

description: 44. Hemiptarsenus ornatus (Nees)
Material examined. 1 ♀, 1 ♂, Israel, Giv’at Hen, ex Gypsophyla (Caryophyllaceae), 3.vi.1982 (A. Friedman) (det. Gijswijt, 1983); 1 ♂, Botanical garden, Tel Aviv, M.T., xi.2010 (Z. Yefremova, V. Kravchenko).
Hosts. Ectoparasitoid of Liriomyza sp., Phytomyza sp. (Diptera: Agromyzidae); Gracillariidae (Lepidoptera) (Bouček & Askew 1968).
Distribution. Israel *; Palearctic (Vidal 2001; Boyadzhiev 2004, 2006).
description: Published as part of Yefremova, Zoya A., 2015, An annotated checklist of the Eulophidae (excl. Tetrastichinae) (Hymenoptera: Chalcidoidea) of Israel, pp. 1-36 in Zootaxa 3957 (1) on page 12, DOI: 10.11646/zootaxa.3957.1.1, http://zenodo.org/record/288546
Simple models of complex systems
Creators: name: Barton, John
Publisher: name: No Publisher Supplied
Year: 2012

description: When the complete description of a complex system of interest is out of reach, simple models which are more amenable to theoretical approach can give a qualitative understanding. In addition, the techniques and ideas developed in investigating simple model systems form a foundation for research on complex phenomena. In this thesis, composed of two parts, we study some representative models from statistical mechanics. In the first part we explore the ABC model, which describes three species of particles with asymmetric interactions. In the second part we consider the inverse Ising problem, using experimental data to infer an effective Ising model.
Role of Id-2 in Breast Cancer and its Relationship to Id-1
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Breast cancer develops as a result of loss of control mechanisms that are crucial for the development and function of the normal breast. The purpose of this proposal is to understand several important aspects of the molecular mechanisms responsible for the loss of growth control and gain of invasive function in breast cancer cells.

 The focus of our investigation will be to study the role of a protein located inside of the cells called Id-2 in these important events in the breast. Id-2 is closely related to a protein we previously studied, Id-1. Our earlier studies demonstrated that the level of Id-1 in breast cells is very carefully controlled during the normal process of growth arrest and gain of function (milk production). When the level of Id-1 becomes too high, these cells begin to grow and invade uncontrollably (signs indicative of incipient cancer), and can no longer become functional and produce milk. More recently, we have obtained evidence that, in mouse breast, the amount of Id-2 is also critical to normal growth, but in the opposite direction of Id-1. That is, it seems that high levels of Id-2 protein are required for normal growth and function. So we believe that low levels of Id-1 and high levels of Id-2 are characteristic of healthy breast cells, while the opposite is true for aggressive cancerous cells. Therefore, based on our findings in cell culture systems and in the mouse mammary gland, we propose that changes in the level of Id-2 protein play a crucial role in breast cancer progression. We believe that the presence of high Id-2 levels is indicative of a good prognosis, and that Id-2 may be lost in cancer cells that spread from the original tumor (metastasis).

 Aggressive, invasive breast cancer cells normally have low levels of Id-2. We will engineer these cells to produce high levels of Id-2, and determine the effects of these high levels on their invasive behavior. We predict that this behavior will be lost or reduced. We will also determine the effect of reducing levels of Id-2 in non-aggressive breast cancer cells. The prediction here is that these cells will become more aggressive, and develop the ability to spread to other organs.

 Our previous work provided important insights into the regulatory mechanisms responsible for many aspects of normal breast development. This proposed work will reveal how the normal regulation may be lost in breast cancer progression, beginning with a localized tumor and developing to a tumor able to spread to other parts of the body. Our central hypothesis is that both Id-1 and Id-2 are involved in determining the fate of normal and transformed (incipiently cancerous) breast epithelial cells, through a coordinated expression of both proteins. Breast would represent the first organ in which the importance of this coordination of Id-1/Id-2 is established.
EDXRD analysis of stress corrosion cracking in 4140 steel
Creators: name: Berke, Brandon Seth
Publisher: name: No Publisher Supplied
Year: 2012

description: The analysis of the strains around the immediate vicinity of a crack tip to  encompass the plastic zone in 4140 steel specimens was undertaken. Each specimen was  subjected to a cyclic loading in air with a KI of 24.2 MPa√m to generate a fatigue crack  around 5.7mm. After a mechanical overload corresponding to a KImax of 38.5 MPa√m in  varying environments (Air, 3.5% NaCl solution simulating sea water and zinc couple to  the 3.5% NaCl solution for generating hydrogen) ranging from inert up to a stress  corrosion cracking (SCC) environment were carried out.  During the overloading process only the specimens in an SCC environment were  subjected to crack activity as expected. For this reason method that hydrogen attacks  steel (hydrogen embrittlement) was a point of curiosity as well. Three SCC specimens  were prepared to stay within different phases: i) no crack growth, ii) onset of crack  growth and iii) crack growth of ~1mm. Two of the specimens (Air and SCC with the  onset of crack growth) were measured by mapping up to all three 3D principle elastic  strains (PES) using a polychromatic high energy synchrotron x-ray probe with photon  energies up to 200 keV in the Laue mode. The PES ε11 and ε22 were directly measured,  iii  while the PES ε33 was obtained from the combined measurement of ε22 and ε23 of the  elastic strain matrix. By using the generalized Hooke’s law and the von Mises yield  criterion for 3D state of stresses in conjunction with the measured PES, maps of the von  Mises equivalent stress (σeq) were obtained. In addition, of the air specimen, the  principle plastic strains and total strains were calculated and used to show the principle  stress fields and equivalent stress field. The results indicated that the PES in the direction  orthogonal to the crack path i.e. the ε22 is sufficient for measuring the plastic zone in  4140 steel.  The use of three models (Linear Elastic Fracture Mechanics (LEFM), Hutchinson-  Rice-Rosengren (HRR) and a blunted crack tip) to define the border of the plastic zone  was employed. These three models were overlaid on the ε22 strain maps. The  juxtaposition of the models with the data showed some varying agreement with the  projected plastic zone size. The models helped estimate that SCC causes the plastic zone  to grow when an SCC crack occurs, due to a lowering of the yield strength of the material  and decreases it ductility.
Women with Breast Cancer: Quality of Life and Diet Adherence
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The most common cancer in women, breast cancer, can be highly distressing and have a major effect on quality of life. Some studies have suggested that a diet that includes high amounts of vegetables, fruit and fiber, and less fat might protect women from recurrence of this disease. The Women’s Healthy Eating and Living (WHEL) Study is a 6-year research program to test the effectiveness of this diet in 3080 California women with breast cancer 2-4 years after completing medical treatment. Regular telephone counseling is included to help the women stick to their dietary plans. This proposal is designed to analyze and report findings based on demographic, psychological, social and quality of life information gathered from these women at the beginning of the study and 1 year later.

 This proposal is designed to provide information about two major concepts. First is to determine which women will have difficulty sticking to their dietary plans. Second is to understand what effect maintaining these dietary plans for 1 year will have on how the participants feel and function in their daily lives and with their families and friends. In addition, the study will look at the use of dietary supplements and also the effect that hot flashesa common problem after breast cancer treatmenthave on how the women feel and function.

 Women entering the study will be randomly assigned to the dietary intervention group or to a control group (which will be given a less-strict diet recommended by the American Cancer Society). Each woman will be scheduled for clinic visits at the beginning and annually for 6 years. At each visit they will be asked to report what they ate the previous day and to fill out some questionnaires which measure social support and difficulties, life problems, mood, optimism, hostility, willingness to express "negative emotions", quality of life, physical and mental concerns, sleep problems, and personal habits. Sophisticated statistical analysis programs will be used.

 This proposal is innovative because it is one of the first to look at how personal characteristics might determine who will stick with the strict diet. It also looks to see if sticking with the diet will improve the womens’ mood, daily functioning, and relationships. Understanding how personal characteristics are related to the use of dietary supplements is a topic relatively new to breast cancer research. Finally, determining how hot flashes affect how women with breast cancer feel and function is important and understudied. All of these findings should help medical and mental health professionals be more effective in tailoring and delivering treatment programs.
Romantic pedantry
Creators: name: Barry, Sean Patrick
Publisher: name: No Publisher Supplied
Year: 2012

description: This dissertation examines how the pedant, a seemingly familiar object of satire, came to personify passionate intellectual absorption in romantic-era writing. The pedant’s ostentatious displays of erudition might seem antithetical to the spirit of an age conventionally associated with the veneration of nature, childhood innocence, and untutored genius. Indeed, pedantry had first attracted attention in eighteenth-century British literature as a problem concerning the performance of specialized knowledge, exemplified by professionals who use jargon outside its proper context. For advocates of polite conversation, excessive attachments to useless knowledge threatened social intercourse by making an individual’s preoccupations a matter of public discourse. Various romantic-era texts, however, imagine other ends for these objects of polite Augustan censure as sources of rhetorical suasion and aesthetic delight. From the late eighteenth to the mid-nineteenth centuries, British writing celebrated the figure of the rambling professional: soldiers, sailors, lawyers, clergymen, and authors whose ardent attachments to useless knowledge structure their conversation and writing. In fact, the romantic pedant’s digressions furnish a recurrent model for literary forms strongly associated with the period. William Hazlitt’s familiar essays, Samuel Taylor Coleridge’s fragmentary autobiography-cum-philosophical treatise, the blathering personae of Walter Scott’s novels, and the antiquarian-inflected speakers of ballads by Robert Burns and William Wordsworth each characterize the relation between feeling and language as an ambivalent product of life in a fragmented world defined by professional specialization. The lyric involution of Wordsworth’s solitaries, the historical musing of Scott’s narrators, and the political and erotic infidelity of Coleridge and Burns are motivated by simultaneous feelings of immersion and rootlessness. Absorbed in process, whether at the level of minute detail or grand abstraction, the romantic pedant loses sight of outcomes and practical ends. In pedantry, romantic-period writing adopted an ubiquitous term of rebuke and refashioned it into a characteristic mental and physical disposition, an individuated persona that typifies impassioned expression.
Hemiptarsenus zilahisebessi Erdos
Creators: name: Yefremova, Zoya A.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Eulophidae
Hemiptarsenus
Hemiptarsenus zilahisebessi

description: 45. Hemiptarsenus zilahisebessi Erdős
Material examined. 1 ♀, Israel, Latrun, sweeping, 3.x.1974 (A. Freidberg); 1 ♀, Meron Field School, M.T., 6.iv.2007 (T. Levanony); 1 ♀, Tel Aviv, M.T., 23.v.2007 (W. Kuslitzky); 1 ♀, Ma’agar Mikha’el, M.T., 29.ii.2009 (W. Kuslitzky); 1 ♂, Tel Aviv, M.T., 17.vii.2011 (Z. Yefremova, V. Kravchenko).
Hosts. Ectoparasitoid of Hypurus bertrandi (Perris) (Coleoptera: Curculionidae); Liriomyza sp. (Diptera: Agromyzidae), Stigmella sp. (Lepidoptera: Nepticulidae) (Bouček & Askew 1968).
Distribution. Israel *; Palearctic (Bouček & Askew 1968; Boyadzhiev 1997; Kalina 1989; Yefremova 2002).
description: Published as part of Yefremova, Zoya A., 2015, An annotated checklist of the Eulophidae (excl. Tetrastichinae) (Hymenoptera: Chalcidoidea) of Israel, pp. 1-36 in Zootaxa 3957 (1) on page 12, DOI: 10.11646/zootaxa.3957.1.1, http://zenodo.org/record/288546
Encapsulated Mesenchymal stromal cells for spinal cord injury repair
Creators: name: Barminko, Jeffrey Avi
Publisher: name: No Publisher Supplied
Year: 2012

description: Spinal cord injury affects a significant portion of the population and unfortunately, current clinical therapeutic options are limited. The progression of SCI pathology is driven by several cellular and molecular post injury events which culminate in an inhibitory scar.   Mesenchymal stromal/stem cells (MSC) robustly produce paracrine factors which successfully attenuate tissue damage and therefore represent a promising cellular SCI therapy. However, current transplantation modalities do not provide control or ensure long term persistence of the cells.  To circumvent these limitations, we investigated the efficacy of alginate microencapsulation in developing an implantable vehicle for MSC delivery. We demonstrate that MSCs remain viable after electrostatic encapsulation with alginate and retain paracrine function. Encapsulated MSCs (eMSCs) promote immunomodulatory macrophage action and prevent degradation of hippocampal tissue in an organotypic model of secondary injury. Pre-clinical animal studies demonstrate the feasibility of transplanting eMSC via lumbar puncture (LP). Capsules localize within the intrathecal space for at least 6 weeks after transplantation, without any observable degradation.  Free MSC (fMSC) transplants were not detectable 1 week after transplantation, while eMSC persisted for at least 2 weeks after injury. eMSC transplantation led to marked improvements in white matter sparing and locomotor function. Overall, these observations support the inclusion of eMSC for post-SCI therapy.  Syringomyelia after SCI can be attributed, in part, to a non-resolving inflammatory presence at the injury site. The Stromal cell represents a key cellular regulator of immune specific functions. Therefore studies were designed to evaluate the regulatory action of MSCs on macrophages during inflammation.   MSC secretion of PGE2 promoted macrophage reprogramming by attenuating pro-inflammatory M1 cytokine secretion and enhancing expression of M2 CD206.  PGE2 reprogramming was mediated through the EP4 receptor and CREB signaling indirectly, via GSK3-α inhibition.  Lastly, MSCs led to a marked increase in CD206 expressing cells at the injury site 1 week after transplantation.   The data here support the role of stromal derived PGE2 in facilitating macrophage reprogramming and establishes GSK3-CREB interactions as a possible regulatory checkpoint in macrophage reprogramming. In conclusion, MSC regulation of immune cell plasticity may be responsible, in part, for their efficacy observed post-SCI transplantation.
Laccocythere Williams & Weaver 2018, new genus
Creators: name: Williams, Bronwyn W.
name: Weaver, Patricia G.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Entocytheridae
Laccocythere

description: Laccocythere Hart & Hart, 1971
1971 Laccocythere new genus.—Hart Jr., C.W. & Hart: 579 (D, R, T).
1974 Laccocythere Hart and Hart, 1971.—Hart & Hart: viii, 153, Fig. 45 (C, D, H, T).
1974 Laccocythere Hart & Hart, 1971.—Hartmann & Puri: 51 (C).
1975 Laccocythere Hart & Hart, 1971.—Hart & Hart: 57 (C, D, H).
description: Published as part of Williams, Bronwyn W. & Weaver, Patricia G., 2018, A historical review of the taxonomy and classification of Entocytheridae (Crustacea: Ostracoda: Podocopida), pp. 1-129 in Zootaxa 4448 (1) on page 102, DOI: 10.11646/zootaxa.4448.1.1, http://zenodo.org/record/1444492
Evaluation of passive RFID system in a dynamic work environment
Creators: name: Ayyer, Shriniwas
Publisher: name: No Publisher Supplied
Year: 2012

description: RFID has been one of the most widely used sensing technologies. Due to its ease of integration, low cost and minimal system intervention required, a lot of domains are deploying RFID for their applications. A major market of RFID technology applications has been the inventory and tracking application. The data obtained from RFID, however, also contains high level of information in it, which can be used and exploited for sensing applications like localization, motion detection, activity recognition, etc. Despite, the widespread use of RFID, there are some technical shortcomings and lack of a system design approach which hinders the performance of RFID systems in dynamic and critical settings. Our goal is to introduce the Passive RFID technology in a dynamic work environment like the Trauma Resuscitation Bay as part of a context-aware system to support activity recognition. Mobility of an object is closely related to its usage and hence the activity being performed.    Detecting mobility of an object using passive RFID technology is the first step towards activity recognition. The deployment of the RFID system and the placement of the antennas play a crucial role in the performance of their sensing application. In this work, we have devised a method to determine the effectiveness of an RFID equipment setup. We have analyzed different RFID setups and we discuss the metrics used to determine their effectiveness. We conducted experiments with different scenarios to collect the data and evaluated the performance of a setup in each scenario. The results obtained helped us to correlate the RFID setup with its detection performance. We also ran a classification algorithm on the data collected and evaluated the object motion detection accuracy for all the set ups. Our work provides a ground rule for the RFID set up requirements to be considered for detection applications and also provides insights into the features that can be used for state classification of objects using the RFID data.
Towards automated classification of fine-art painting style
Creators: name: Arora, Ravneet Singh
Publisher: name: No Publisher Supplied
Year: 2012

description: This thesis presents a comparative study of different classification methodologies for the task of fine-art genre classification. The problem of painting classification involves classifying new unknown paintings among different art genres. Two-level comparative study is performed for this classification problem. The first level reviews the performance of discriminative vs. generative models while the second level touches the features aspect of the paintings and compares Semantic-level features vs low-level and intermediate-level features present in the painting. Three models are studied and compared, namely - 1) A Discriminative model using a Bag-of-Words (BoW) approach; 2) A Generative model using BoW; 3) Discriminative model using Semantic-level features. Various experiments and techniques like Bag of Words model, Topic models and Classeme features are employed to get insights into potential of these automatic classification techniques for painting styles.
Laccocythere aotearoa Hart Jr., C. W. & Hart 1971, new species
Creators: name: Williams, Bronwyn W.
name: Weaver, Patricia G.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Entocytheridae
Laccocythere
Laccocythere aotearoa

description: * Laccocythere aotearoa Hart & Hart, 1971
1971 Laccocythere aotearoa new species.—Hart Jr., C.W. & Hart: 579–582, Figs. 1 –8 (A, D, H, R, T).
1974 Laccocythere aotearoa Hart and Hart, 1971.—Hart & Hart: 145, 153–154, 216, 235, Pl. XL Figs. 18–21, Pl. LIX (C, D, H, K, T).
1975 Laccocythere aotearoa Hart & Hart, 1971.—Hart & Hart: 57 (C, D, H).
2014a Laccocythere aotearoa Hart & Hart, 1971.—Mestre, Monrós & Mesquita-Joanes: 931, 950 (C).
description: Published as part of Williams, Bronwyn W. & Weaver, Patricia G., 2018, A historical review of the taxonomy and classification of Entocytheridae (Crustacea: Ostracoda: Podocopida), pp. 1-129 in Zootaxa 4448 (1) on page 102, DOI: 10.11646/zootaxa.4448.1.1, http://zenodo.org/record/1444492
Lichnocythere Hart & Hart 1967
Creators: name: Williams, Bronwyn W.
name: Weaver, Patricia G.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Lichnocythere

description: Lichnocythere Hart & Hart, 1967
1967b Lichnocythere gen nov.—Hart & Hart: 6, 7, 23–24, 50 [by association], 51, Fig. 95 (D, K, R, T).
1967 Lichnocythere.—Hart, Nair & Hart: 4 (R).
1969b Lichnocythere.—Hart & Hart: 158 (R, T).
1974 Lichnocythere Hart and Hart, 1967.—Hart & Hart: viii, 10, 144, 145, 154, Fig. 46 (C, D, H, K, T).
1974 Lichnocythere Hart & Hart, 1967.—Hartmann & Puri: 51 (C).
1975 Lichnocythere Hart & Hart, 1967.—Hart & Hart: 57 (C, D, H).
description: Published as part of Williams, Bronwyn W. & Weaver, Patricia G., 2018, A historical review of the taxonomy and classification of Entocytheridae (Crustacea: Ostracoda: Podocopida), pp. 1-129 in Zootaxa 4448 (1) on page 102, DOI: 10.11646/zootaxa.4448.1.1, http://zenodo.org/record/1444492
Squatters, vampires, and personalities
Creators: name: Balkin, Sarah
Publisher: name: No Publisher Supplied
Year: 2012

description: "Squatters, Vampires, and Personalities" argues that modern drama emerged through convergences of multiple genres, narration, and dramatic form during the late nineteenth century. My dissertation is a work of historical formalism that shows how formal elements combine with the conditions of theatrical production and publication to produce new forms of drama. Recent scholarship across literary studies has returned to considerations of form inflected by the lessons of historicism and various forms of literary theory, but this ―formalist turn‖ has not yet spurred reconsideration of the overarching narratives of dramatic development. My work on George Eliot, Henrik Ibsen, August Strindberg, and Oscar Wilde uses genre as a historically specific way of studying form and supplies a new understanding of dramatic modernism‘s engagement with interiority and epic. I argue that modern drama demands an intergeneric critical approach; thus, I juxtapose drama with narrative fiction and criticism from the Victorian and modernist canon. The generic shifts of Eliot‘s The Mill on the Floss (1860), for example, set up a relationship between interiority, narration, dramatic form, and external circumstances against which I position the narrator types—squatters, vampires, and personalities—that structure my dissertation. I call Ibsen‘s characters squatters because they illegitimately occupy other people‘s homes (the domestic interiors on the stage) by rhetorically inserting themselves into the past lives of present residents. The play and novel characters that Strindberg calls vampires also attempt to control the environments they inhabit through performative narration, draining people, households, and linguistic conventions of vitality and meaning in the process. In Wilde‘s plays, fiction, and essays, this movement across formal and social conventions is embodied in narrator, critic, and dandy characters through which Wilde articulates and performs the project of ―realizing personality‖—a paradoxical quest for a self that constructs people out of (and in resistance to) artistic genres. Thus, my dissertation moves from a novelistic character who approaches the world-altering powers of a narrator, to stage characters who narrate, to characters who are produced by onstage narration. Through these characters‘ relationships to language and the material stage my dissertation yields a new history of dramatic form.
Hemiptarsenus unguicellus Zetterstedt
Creators: name: Yefremova, Zoya A.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Eulophidae
Hemiptarsenus
Hemiptarsenus unguicellus

description: 46. Hemiptarsenus unguicellus (Zetterstedt)
Material examined. 1 ♂, Israel, Tel Aviv, M.T., 1.v.2007 (W. Kuslitzky); 2 ♀, 2 ♂, Tel Aviv, M.T., 19.vii.2007 (W. Kuslitzky); 1 ♀, Bet Dagan, 32°00’N; 34°50’E M.T., 19.v.2008 (W. Kuslitzky); 1 ♂, Ma’agan Mikha’el, M.T., xi.2008 (W. Kuslitzky); 1 ♂, Ma’agan Mikha’el, M.T., 29.iv.2009 (W. Kuslitzky); 1 ♂, Bor Mashash, sweeping, 31°06’N; 34°49’E, iv.2007 (D. Gerling).
Hosts. Ectoparasitoid of Agromyzidae (Diptera); Elachistidae, Noctuidae and Pyralidae (Lepidoptera) (Bouček & Askew 1968).
Distribution. Israel *; Palearctic (Bouček & Askew 1968; Boyadzhiev 2004, 2006; Yefremova et al. 2010).
description: Published as part of Yefremova, Zoya A., 2015, An annotated checklist of the Eulophidae (excl. Tetrastichinae) (Hymenoptera: Chalcidoidea) of Israel, pp. 1-36 in Zootaxa 3957 (1) on page 12, DOI: 10.11646/zootaxa.3957.1.1, http://zenodo.org/record/288546
On the physical and chemical dynamics of chromatin
Creators: name: Apratim, Manjul
Publisher: name: No Publisher Supplied
Year: 2012

description: The research performed leading to this dissertation is an endeavor to explore two broad classes of developmental phenomena in the chromatin complex in eukaryotic cells --- physical, for instance, long range interactions between enhancers and promoters, and chemical, such as epigenetic chromatin silencing. I begin by introducing the reader to both types of phenomena, and then set the stage for our strategy in the exploration of the physical side of these processes by creating a new machinery from existing pieces of polymer physics. I then make a brief foray into theoretical realms in an attempt to answer the question of what kinds of conformations of polymers dominate in what regimes. Subsequently, I proceed to consider the problem of analyzing and interpreting data from a major technique of probing the behavior of the chromatin complex in vivo --- Chromosome Conformation Capture --- towards which end we have developed and implemented a new and robust algorithm called `G.R.O.M.A.T.I.N.'. Subsequently, I explore how similar ideas may be invoked in the analysis of direct microscopic observations of native chromatin structure via Fluorescence in situ Hybridization. Following this, I look at the problems of epigenetic chromatin silencing domain formation and stability in the presence of titration feedback and of stochastic noise, and demonstrate how the widely accepted polymerization model of silencing is consistent with Chromatin Immunoprecipitation data from silencing domains in budding yeast. I finally conclude with musings on recent evidence pinpointing the need to unify the physical and chemical pictures into one grand formulation.
Vanikoridae
Creators: name: Leal, José H.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Littorinimorpha
Vanikoridae

description: Family Vanikoridae
Macromphalina garcesi Rolán & Rubio, 1998 (Figure 26); two paratypes.
Macromphalina paradoxa Rolán & Rubio, 1998 (Figure 27); one paratype.
Macromphalina redferni Rolán & Rubio, 1998 (Figure 28); 72 paratypes.
Macromphalina robertsoni Rolán & Rubio, 1998 (Figure 29); two paratypes.
description: Published as part of Leal, José H., 2021, Type specimens in the molluscan collection of the Bailey-Matthews National Shell Museum, Florida, USA, pp. 1-40 in Zootaxa 4951 (1) on page 5, DOI: 10.11646/zootaxa.4951.1.1, http://zenodo.org/record/4655535
Risk and performance analysis of ports and waterways
Creators: name: Almaz, Ozhan Alper
Publisher: name: No Publisher Supplied
Year: 2012

description: Delaware River is one of the major maritime arteries in the U.S. The port has a number of major petroleum refineries making it one of the most critical petroleum infrastructures in the U.S. Consequently, in addition to port performance issues, major safety vulnerabilities exist in view of the vessel traffic in the river carrying potentially dangerous cargo, dry cargo as well as passenger ships, among others.    In this research, several issues regarding the risk and performance analysis of ports and waterways are investigated through the case of Delaware River and Bay. The issues pertaining to Delaware River are common to many other ports and waterway systems. Thus, modeling and analysis approaches presented herein provide guidelines that can be implemented to other systems.    The dissertation presents a simulation model of the vessel traffic in Delaware River and Bay (DRB) involving all vessel types and all the port terminal facilities along the navigable river. The simulation model is built to be able to perform scenario and policy analyses, including investigation of the effects on port performance of deepening the main ship channel and dredging at terminals. The model is also used to examine the feasibility and the effects of port expansion projects, and to perform logistics and risk analysis in the DRB area.    A probabilistic risk model is developed using historical data and expert opinion elicitation for the unknown accident and consequence probabilities of various situations. The risk model is incorporated into the simulation model to be able to evaluate risks and to produce a risk profile of the entire river.    The important topic of vessel prioritization is studied using the simulation and the risk models. Vessel prioritization rules are used for entry into the river during recovery operations following a channel-closing event, and their impact on risk and port performance measures are evaluated.    Finally, vessel arrival processes at terminals are examined with reference to the real life practice at ports and waterways. These processes are characterized with one-dimensional point processes, and variation and correlation properties are investigated. The focus is modeling vessel arrivals with specific correlation properties to use in simulation studies.
Bax gene expression in breast cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Essentially all chemotherapeutic drugs commonly used in the treatment of cancer, as well as radiation have been shown to ultimately kill cancer cells by triggering a form of cell death called "apoptosis". Consequently, alterations in the regulation of cellular genes that control the apoptotic cell death play an important role in determining the relative chemosensitivity and resistance of tumors. Recently, we obtained evidence that the pro-apoptotic gene BAX is normally turned-on ("expressed") in breast tissue, but becomes inactive in approximately one-third of invasive breast cancers. In a study of 119 women with metastatic breast cancer, we found that patients whose tumors had lost BAX activity had poorer responses to combination chemotherapy, faster time to tumor progression, and shorter overall survival.

 We study the molecular mechanisms that regulate the activity of the BAX gene in breast cancer so that we might one day be able to improve tumor responses to currently available anticancer drugs. In this regard, it has been shown that radiation and DNA-damaging anticancer drugs can induce expression of BAX, suggesting that turning on this pro-apoptotic gene may be important for chemoresponses. We have recently delineated one of the factors that can regulate BAX gene activity. This regulator of BAX is called p53, a recognized tumor suppressor gene.

 Taken together, these investigations will determine the clinical relevance of decreases in BAX gene activity for women with breast cancer, and will begin to provide insights into some of the molecular mechanisms that account for loss of BAX gene expression in metastatic breast cancers.

 Thus far, our attempts to understand how p53 controls BAX expression have taught us that either p53 is insufficient by itself to induce BAX in many types of cells, including human breast cancers, or that other factors are suppressing the effects of p53 on BAX. Experiments are in progress to differentiate between these two possibilities. In addition, we have extended our original analysis of BAX in human breast specimens to another 150 patients, and have confirmed that approximately one-third of patients lack BAX expression. Once the mechanisms responsible for the failure of approximately one-third breast tumors to express BAX are understood at the molecular level, then we can begin to devise strategies restoring BAX or supplanting it with something else that improves the responses of patients to chemotherapy and radiotherapy.
La necesidad de narrar
Creators: name: Adriasola-Velasco, Juan Jose
Publisher: name: No Publisher Supplied
Year: 2012

description: This dissertation studies a corpus of Chilean narrative texts published from the late 1980s to the 2000s, understanding them as active participants of the social processes of the period. The corpus includes works by Gonzalo Contreras, Alberto Fuguet, Carlos Franz, Ramón Díaz Eterovic, Diamela Eltit, Gonzalo León and Marcelo Mellado. Through the analysis of the literary texts and their relation to public/cultural discourses (both official and non-official), I describe the political positions that can be traced within those narratives, both in their fiction and their enunciation. The positions described are grouped by the way in which they address their social context, as well as textual strategies that concern narration as a political practice. Taking into account the specific Chilean experience of capitalism, implemented during the dictatorship and consolidated in the later democratic governments, an important part of the characterization of these three positions relates to the representation of violence and mourning. Drawing on the work of intellectuals such as Walter Benjamin, Hannah Arendt, Frantz Fanon and Slavoj Žižek, I address the theoretical discussion regarding violence as a social phenomenon as well as the difficulties of its representation. The ways in which violence is represented in the literary texts situates them in specific and socially representative practices and discourses. The political positioning that derives from the narration of violence, responds both to its representation and the strategies by which the reader is invited to see that violence. The question of mourning is addressed in relation to the practices that are implied with regards to the representation of violence and the invoked function of the reader. In dialog with the work of Sigmund Freud and Idelber Avelar, I describe and evaluate the ways in which mourning is deferred or sought through these practices of narration. This responds to an ethical problem, as understood by Jacques Lacan and Alain Badiou, where the main question pertain the subject – his relation to his desire, and his place within a political structure. This is observed in the texts through the analysis of both the represented subjects and the reader as a function.
The influence of neighborhood characteristics, peer delinquency, and attitudes approving of violence during adolescence on male-to-female intimate partner violence perpetration in young adulthood
Creators: name: Allegra, Christine Marian
Publisher: name: No Publisher Supplied
Year: 2012

description: Intimate partner violence (IPV) is a serious crime and public health problem in the United States.  Past research on neighborhood-, peer-, and individual-level predictors of IPV have been cross-sectional, and few studies have investigated all three predictors in one mediation model.  Even fewer studies have been longitudinal or have examined associations separately by race.  Using data from the Pittsburgh Youth Study, the purpose of this dissertation was to address these gaps in the literature.  This dissertation examined the indirect effects of neighborhood disorder and the intervening mechanisms of attitudes approving of violence and peer delinquency on male-to-female physical IPV perpetration from adolescence into young adulthood.  The analyses were run separately for Blacks and Whites.    The findings showed that neighborhood disorder was not associated with any variables of interest for either Black or White respondents.  Among perpetrators of physical IPV, greater neighborhood disorder was associated with more approving attitudes of violence for the White sample only.  Due to the lack of statistically significant correlations among the variables included in the model, the hypothesized model was not tested.  Two exploratory models examined whether peer delinquency mediated the relationship between attitudes approving of violence and IPV perpetration for the White sample.  The exploratory models were not tested for the Black sample because no statistically significant relationships had been found.  The results of both exploratory analyses indicated that for White adolescents, attitudes that were more accepting of violence were associated with having more delinquent peers, and in turn, the association with delinquent peers was related to higher levels of IPV perpetration in young adulthood.  The strength of the indirect effect of attitudes on IPV perpetration was stronger in the model that examined attitudes approving of violence and peer delinquency at the same point in time (mean of ages 16 and 17) than in the model that examined attitudes approving of violence at mean age 16 and peer delinquency at mean age 17.  These results highlight a need to provide IPV-prevention strategies that target attitudes toward violence and associations with delinquent peers during adolescence.
Extinction risk from habitat fragmentation using metapopulation-based metrics
Creators: name: Schnell, Jessica K.
Publisher: name: No Publisher Supplied
Year: 2012

description: The world is becoming more developed as the human population steadily grows. With the increase in human influence, anthropomorphic habitat loss will only increase over time. Habitat fragmentation is the leading threat to species globally. Assessing fragmentation and determining sites of the most critical regions is vitally important for conservation efforts. One way of assessing fragmentation is by relating the spatial aspect to the biological aspect, via metapopulation dynamics. Specifically, metapopulation capacity allows for relative valuation of fragmented landscapes. However, a modification is required for it to operate at large-scale landscapes. The modified metric enables relative quantification value of fragmented habitat, with biological relevance for long-term extinction risk. Using the same spatially explicit components of metapopulation theory, we can also create a short-term measure of extinction risk, based on the instantaneous rate of expected decline post-fragmentation. This metric, extrapolated persistence time, along with the modified metapopulation capacity metric, can then be used in a variety of ways to determine high risk species and regions.    Given that bird species are capable of an assortment of dispersal abilities, focusing within phylogenetic groups allows for more relevant comparisons between species. With the use of slopegraphs, we can instantly determine those species, within their families, with remaining ranges that have extremely low relative values for long or short term extinction risk. Of particular concern are those species considered to be at low risk of threat by the IUCN Red List, yet possess habitats that are critically fragmented. The metrics can be utilized in estimating overall landscape value, and estimating the contribution of specific patches to the overall landscape value; this would be useful in preservation and management decisions. Finally, by focusing on those cells that connect large patches, we can determine where restoration of habitat should be prioritized, for anything from the greatest increase in metapopulation capacity to the most number of species with ranges that could be reconnected.
Hemiptarsenus wailesellae Nowicki
Creators: name: Yefremova, Zoya A.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Eulophidae
Hemiptarsenus
Hemiptarsenus wailesellae

description: 47. Hemiptarsenus wailesellae Nowicki
Material examined. 1 ♀, Israel, Almagor, 32°54’ N; 35°35’E, 17-28.vi.2011 (W. Kuslitzky); 2 ♀, Hefer Valley, 32°22’ N; 34°35’E, 31.vii. 2013, 13m suction (M. Kishenevsky).
Hosts. Ectoparasitoid of Leucoptera wailesella Stainton (Lepidoptera: Lyonetiidae) (Bouček & Askew 1968), Stigmella sp. (Nepticulidae: Lepidoptera) (Bouček 1977).
Distribution. Israel *; Palearctic (Bouček 1977; Boyadzhiev 1997; Kalina 1989).
description: Published as part of Yefremova, Zoya A., 2015, An annotated checklist of the Eulophidae (excl. Tetrastichinae) (Hymenoptera: Chalcidoidea) of Israel, pp. 1-36 in Zootaxa 3957 (1) on page 13, DOI: 10.11646/zootaxa.3957.1.1, http://zenodo.org/record/288546
Lichnocythere synethes Hart & Hart 1967, sp. nov.
Creators: name: Williams, Bronwyn W.
name: Weaver, Patricia G.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Lichnocythere
Lichnocythere synethes

description: Lichnocythere synethes Hart & Hart, 1967
1967b Lichnocythere synethes sp. nov. —Hart & Hart: 7, 8, 25–26, 44, 45, Figs. 67–69 (A, D, H, K, R, T).
1974 Lichnocythere synethes Hart and Hart, 1967.—Hart & Hart: 145, 155, 217, 237, Pl. XLI Figs. 1 –3, Pl. LXI (C, D, H, K, R, T).
1975 Lichnocythere synethes Hart & Hart, 1967.—Hart & Hart: 58 (C, D, H).
2014a Lichnocythere synethes Hart & Hart, 1967.—Mestre, Monrós & Mesquita-Joanes: 950 (C).
description: Published as part of Williams, Bronwyn W. & Weaver, Patricia G., 2018, A historical review of the taxonomy and classification of Entocytheridae (Crustacea: Ostracoda: Podocopida), pp. 1-129 in Zootaxa 4448 (1) on page 102, DOI: 10.11646/zootaxa.4448.1.1, http://zenodo.org/record/1444492
Endosomal receptor trafficking and signal transduction in Schwann cells
Creators: name: Reddy, Kavya
Publisher: name: No Publisher Supplied
Year: 2012

description: Neuregulin1-ErbB signaling is important for various functions during Schwann cell development and myelination. Activation of the ErbB receptors also triggers myelin breakdown in mature myelinating Schwann cells. The mechanism by which the activated ErbB receptor complex elicits multiple biological functions in Schwann cells is unclear. In Charcot-Marie-Tooth (CMT) disease - the most common demyelinating neuropathy in the peripheral nervous system - many proteins involved in regulating intracellular vesicular trafficking and sorting through the endocytic pathway are found mutated.  Endocytic pathways are also strongly implicated in the regulation of signal transduction by cell surface receptors. It is possible that aberrant regulation of the ErbB receptors and  downstream signal activation by the impaired endocytic components contribute to the disease manifestation. The function of ErbB receptor trafficking and signal modulation in Schwann cells is largely unknown. We hypothesized that Nrg1-induced ErbB2 and ErbB3 receptor trafficking can differentially regulate signaling by spatially and temporally localizing receptors in different endocytic compartments. In this study, we show that following treatment with soluble Nrg1, internalized ErbB receptors are sorted into the late endosome/lysosome for degradation or transported to the recycling endosome and reappear on the cell surface. ErbB receptor recycling is also regulated by Nrg1 dose. Inhibition of receptor endocytosis by impairing dynamin activity blocked the Nrg1-induced Akt activation and abrogated the pro-myelinating effect in co-cultures. Interestingly, allowing receptor endocytosis but inhibiting the subsequent recycling from the early endosome enhanced Akt activation, indicating the importance of the early endosomal signaling for the Nrg1-induced Akt activity.  Supporting this, sub-cellular fractionation showed that active Akt was enriched in the endosomal fraction in Schwann cells.  We also investigated the mechanism by which membrane-bound Nrg1 Type III regulates ErbB receptor trafficking in Schwann cells.  Binding of the axonal Nrg1 induced both ErbB2 and ErbB3 downregulation indicating receptor internalization.  The membrane-bound Nrg1 Type III was also internalized into the Schwann cells, appearing in Rab5-positive early endosomes.  The Nrg1-induced Akt activation, which is necessary for myelination was abrogated when receptor endocytosis in Schwann cells was blocked.  Our results show that endocytic trafficking is important for the pro-myelinating function of Nrg1.  The results also suggest that impaired endocytic pathways may contribute to the development of demyelinating neuropathy by resulting in aberrant regulation of the Nrg1-ErbB signaling in Schwann cells.