cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: 02_0046
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Other Writings on F.F. Bosworth: A Brief Bibliography
Creators: name: Barnes, Roscoe
Publisher: name: figshare
Year: 2017
Subjects: Religious Studies
Literature
History

description: This annotated list of references presents the writings on F.F. Bosworth that are biographical, critical, and devotional in nature. The list includes books, news reports, articles, and audio recordings.NOTE: This list does not include the articles on Bosworth that are written by Roscoe Barnes III. For a full list of Barnes’ work on this Pentecostal pioneer, see https://ffbosworth.strikingly.com or visit https://independent.academia.edu/RoscoeBarnesIII .
title: Scotland, Malawi and the post-development critique: an analysis of power and equality in international development
Creators: name: Wilson, Ben Robert Lamb
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: Post-development, international development, dependency theory, development discourse, participation, Scotland, Scottish Government, Malawi, partnership, extraversion, Scotland Malawi Partnership, post-colonialism, David Livingstone, international volunteers, voluntourism.

description: The purpose of this thesis is to analyse contemporary efforts to make international development more equal, through the application of the post-development critique to the relationship between Scotland and Malawi. Post-development theorists posit that international development is a neo-colonial form of action that is premised on, and perpetuates, conceptual and material inequalities between ‘developed’ and ‘developing’ countries. The Scotland and Malawi relationship is presented by its proponents as an example of a contemporary development practice that challenges these embedded inequalities, based on its people-to-people approach which emphasises mutuality, reciprocity and friendship between the two countries. This thesis therefore brings the post-development critique to this relationship to understand the enduring power inequalities in the contemporary development discourse. An interpretivist qualitative methodology was utilised to explore the perceptions and practices of a variety of organisations and individuals working within the Scotland-Malawi relationship. These methods included semi-structured interviews, participant observation, textual analysis and focus groups. This included a longitudinal focus group study with student groups travelling from Scotland to Malawi before, during and after their trips, to analyse how young people's perceptions were shaped by the contemporary development discourse. This research uncovered the precise ways that contemporary development discourse perpetuates power inequalities in development interactions. These inequalities are shown to be embedded in the colonial cross-national relationships that development relations are often based on, and through the process of othering of people in countries that receive aid. By deploying Bayart’s theory of extraversion, and applying this as an analytical tool, this thesis also offers a new way of understanding agency in post-development theory. Though this analysis, this thesis demonstrates the enduring value of the post-development critique as a means of understanding the dynamic and complex ways that power is negotiated in development. Ultimately, this thesis concludes that the development discourse requires unequal power relations in order to function, and efforts to challenge this from within the industry are unsuccessful.
title: Sir William Burrell (1861-1958): the man and the collector
Creators: name: MacDonald, Isobel Caroline
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: Sir William Burrell, The Burrell Collection, Glasgow, history of collections, collecting, Glasgow museums, dealers, collector's interior.

description: This thesis analyses the life and collecting career of the Glaswegian mercantile collector Sir William Burrell (1861-1958). It covers the period from 1882, his first recorded purchase, to 1983, the year that The Burrell Collection first opened in Pollok Country Park, Glasgow. This involves placing Burrell into the context of late nineteenth and early twentieth century middle-class collectors, who were distinct from their aristocratic predecessors through their support of modern and contemporary artists and art movements. Although Burrell’s collecting interests were catholic, ranging from medieval tapestries and stained glass, to Persian carpets, Chinese ceramics and bronzes, historical furniture, modern European painting and much more, this thesis illustrates his engagement with his contemporary artistic context. Throughout his collecting career Burrell loaned his objects to public exhibitions and institutions, highlighting his belief in the public’s access to art, something that ultimately led to his gift of the collection to Glasgow in 1944. Burrell’s collection comprises of over 8,000 objects. Rather than examine individual areas of the collection, this thesis considers it as an object itself, one that has had varying forms and values over time but was ultimately brought together through the act of the gift. In light of this, four main themes are examined: public mindedness, relationships, identity and legacy. Within these themes overarching research questions are posed: how did Burrell collect, what drove his acquisitions, and what were his intentions for his collection. Through the use of a broad range of archival material, this thesis builds up an image of Burrell the collector through the lens of his contemporaries. It is a biographical analysis of both man and collection, and seeks to understand the collector through the objects that he acquired. It ultimately reveals that what unites Burrell’s wide-ranging collection was his interest in artistry and craftsmanship, and his desire to learn through the objects that he collected. This not only affected what he bought but also who his closest associates were. This thesis reassesses Burrell, opening up new ways to consider him as a collector in the late nineteenth and twentieth century.
Isomeric organic ligand dominating polyoxometalate-based hybrid compounds: synthesis and as electrocatalysts and pH-sensitive probes
Creators: name: Li, Xiao
name: Wang, Yunlong
name: Zhou, Kunfeng
name: Wang, Yunliang
name: Han, Tao
name: Sha, Jingquan
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: By introducing isomeric organic ligands into polyoxometalate (POM) systems, two new POM-based hybrid compounds, [Cu6(m-pyttz)2(H2O)][HPMo12O40] (1) and [Ag3(p-H2pyttz)(p-Hpyttz)Cl][H2PMo12O40]·6H2O (2) (m-/p-H2pyttz = 3-(pyrid-3/4-yl)-5(1H-1,2,4-triazol-3-yl)-1,2,4-triazolyl), have been hydrothermally synthesized and characterized. Single-crystal structural analysis shows the m-pyttz ligands link CuI ions to generate a two-dimensional layer with hanger-like rhombus, which is pillared by the PMo12 anions in 1. Compound 2 exhibits a three-dimensional supramolecular framework, in which PMo12 anions are building blocks facilitating the extension of the whole structure. The influence of the coordination modes of m-/p-H2pyttz on the structures is discussed in detail. Furthermore, electrochemical properties of 1 and 2 have been studied and they display excellent electrocatalytic activities toward the reduction of nitrite and hydrogen peroxide and pH-dependent electrochemical behaviors.
Isomeric organic ligand dominating polyoxometalate-based hybrid compounds: Synthesis and as electrocatalysts and pH-sensitive probes
Creators: name: Li, Xiao
name: Wang, Yunlong
name: Zhou, Kunfeng
name: Wang, Yunliang
name: Han, Tao
name: Sha, Jingquan
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: By introducing isomeric organic ligands into polyoxometalate (POM) systems, two new POM-based hybrid compounds, [Cu6(m-pyttz)2(H2O)][HPMo12O40] (1) and [Ag3(p-H2pyttz)(p-Hpyttz)Cl][H2PMo12O40]·6H2O (2) (m-/p-H2pyttz = 3-(pyrid-3/4-yl)-5(1H-1,2,4-triazol-3-yl)-1,2,4-triazolyl), have been hydrothermally synthesized and characterized. Single crystal structural analysis shows the m-pyttz ligands link CuI ions to generate a two-dimensional layer with hanger-like rhombus, which is pillared by the PMo12 anions in 1. Compound 2 exhibits a three-dimensional supramolecular framework, in which PMo12 anions are building blocks facilitating the extension of the whole structure. The influence of the coordination modes of m-/p-H2pyttz on the structures is discussed in detail. Furthermore, electrochemical properties of 1 and 2 have been studied and they display excellent electrocatalytic activities toward the reduction of nitrite and hydrogen peroxide and pH-dependent electrochemical behaviors.
title: Scotland and the sexual revolution c. 1957-1975: religion, intimacy and popular culture
Creators: name: Lynch, Charlie
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: Sexualities, Scotland, religion, heterosexuality, popular culture.

description: This thesis examines popular cultural change and intimate life in Lowland Scotland between the late 1950s and the mid-1970s. This period has long been associated by scholars with a ‘sexual revolution’ unfolding across the Western World, yet the nature and extent of this phenomenon in Scotland has remained mysterious. Using twenty newly conducted oral history interviews, as well as other source material including reportage and commentary, this thesis explores how Scotland’s dominant Presbyterian culture impacted upon young people’s intimate lives, and how its discursive power lessened during the sixties. Through presenting a series of illustrative case studies ranging in focus from the emergence of crisis points at university campuses in the late sixties, to the arrival of a more liberal heterosexual culture amongst young adults in the early seventies, this thesis contributes to our knowledge of post war Scottish society and addresses a large gap in existing scholarship. It argues that in the early sixties, understandings and experiences of heterosexuality were dominated by Christian discourses. By later in the decade, this moral world was in rapid decline, for it was being undermined by a collapse in the religiosity of young people and changes to popular culture. A heterosexual culture began to emerge which deviated from theology, and which emphasised increased personal autonomy, greater choice in relationships and sex as pleasure rather than duty. Numbers of young, urban people created pressure for access to more liberal lifestyles, and their intimate lives were key to understanding how this change took place. These developments were met by conservative reactions which attempted to re-assert the primacy of the earlier culture and which revealingly drew upon Christian ideas about sex and purity. Through exploring the cultural contexts of changes and continuity in attitudes and behaviours, and responses to them by institutions, this study provides a fresh perspective on a range of issues including the religious crisis of the sixties, the social effects and implications of cultural innovation and lifestyle change, and the policing and social control of sexualities.
Altmetrics and Archives
Creators: name: Kelly, Elizabeth Joan
Publisher: name: figshare
Year: 2017
Subjects: subject: Library and Information Studies
subject: FOS: Media and communications
subject: 80706 Librarianship

description: Altmetrics are an alternative to traditional measurement of the impact of published resources. While altmetrics are primarily used by researchers and institutions to measure the impact of scholarly publications online, they can also be used by archives to measure the impact of their diverse online holdings, including digitized and born-digital collections, digital exhibits, repository websites, and online finding aids. Furthermore, altmetrics may fill a need for user engagement assessments for cultural heritage organizations. This article introduces the concept of altmetrics for archives and discusses barriers to adoption, best practices for collection, and potential further areas of study.

This is a post-print [post-peer review] version of a manuscript originally published in Journal of Contemporary Archival Studies: Vol. 4 , Article 1. http://elischolar.library.yale.edu/jcas/vol4/iss1/1
 
title: The regulation of developments after the coming in to force of the Title Conditions (Scotland) Act 2003: implied rights to enforce, interest to enforce and the Development Management Scheme
Creators: name: O'Neill, Bernadette
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: regulation of developments, real burdens, title conditions, Title Conditions (Scotland ) Act 2003, implied rights to enforce real burdens, interest to enforce real burdens, Development Management Scheme, common scheme burdens, amenity burdens, related properties, title insurance, material detriment to value or enjoyment.

description: The law of real burdens developed in Scotland in a piecemeal fashion over 200 years, resulting in a series of arcane rules which left property owners unclear about their rights and complicated the sale and purchase of property. The Title Conditions (Scotland) Act 2003 (TCA) represented a major overhaul of the law in this area, aiming to clarify and modernise provision on real burdens and bring certainty while reducing costs. This thesis looks at how the TCA is working in practice and evaluates whether those aims have been achieved in relation to three key parts of the TCA, namely implied rights to enforce, interest to enforce and the Development Management Scheme (DMS). In addition to a systematic exploration of the background to the reforms, my research involved empirical work with solicitors and insurers to ascertain their experiences with the new rules. The case law in these key areas is fairly limited and has not provided clear guidance, with many resorting to insurance as a solution to the uncertainty in the law of implied rights and interest to enforce, while the DMS appears to have been largely ignored by the profession. This thesis sets out my findings on the operation of the law in practice, considering particularly the difficulty for practitioners in understanding and applying the rules on implied enforcement rights for common scheme burdens and interest to enforce, and the knock-on effect for clients in terms of transaction timescales and costs. Issues with some aspects of the DMS raised by practitioners and academics are also explored.
Uncertainty quantification of criticality in solid-moderated and -reflected cores at Kyoto University Critical Assembly
Creators: name: Pyeon, Cheol Ho
name: Yamanaka, Masao
name: Ito, Makoto
name: Chiba, Go
name: Endo, Tomohiro
name: Kim, Song Hyun
name: van Rooijen, Willem Fredrik G.
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Inorganic Chemistry
subject: Hematology
subject: Plant Biology
subject: FOS: Biological sciences

description: Uncertainty quantification is conducted for the criticality of excess reactivity and control rod worth obtained at the Kyoto University Critical Assembly (KUCA). By combining SRAC2006 and MARBLE code systems, the sensitivity coefficients of the cross sections for aluminum-27 (27Al) comprising mainly of core components are large in the solid-moderated and -reflected cores (A cores) at KUCA. Also, the uncertainty is dominant in the uranium-235 isotope by the covariance data of JENDL-4.0, and a quantitative value is about 150 pcm induced by the JENDL-4.0 data library in the KUCA A cores, whereas the covariance data of 27Al are not prepared in JENDL-4.0. Moreover, the effect of decreasing uncertainty is obtained by applying the cross-sectional adjustment method to the uncertainty analyses. From the results, a series of uncertainty quantifications is expected to clarify the uncertainty of sub-criticality in accelerator-driven system experiments with spallation neutrons in the KUCA A cores.
Review protocol celiac disease and enamel defects.docx
Creators: name: Franchi, Lorenzo
Publisher: name: figshare
Year: 2017
Subjects: subject: 110505 Oral Medicine and Pathology
subject: FOS: Clinical medicine

description: Protocol for a systematic review and meta-analysis

 Title of the systematic Review:
Enamel defects and aphtous stomatitis in celiac patients and normal controls: systematic review and meta-analysis of controlled studies

Review question
Comparison of enamel defects and aphtous stomatitis between celiac patients and healthy controls

Searches
3 electronic databases were serched: PubMed, Embase, and Google Scholar. Grey iterature was serached on OpenGray. Manual serach was performed in the following journals starting from Jan 1990: European Journal of Paediatric Dentistry, Pediatric Dentistry, Community dentistry and oral epidemiology, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, Journal of pediatric gastroenterology and nutrition, Gastroenterology, The American journal of gastroenterology, Journal of gastroenterology, Journal of dental research.

Participants/population
Children (up to 18 years) and adults with celiac disease compared to healthy individuals

Intervention(s), exposure(s)
Patients with celiac disease

Comparator(s)/control
Healthy individuals

Types of study to be included
Controlled studies (cohort, cross-sectional, and case control studies)

Primary outcome(s)
Presence/absence of enamel defects and presence/absence of aphtous stomatitis

Risk of bias (quality) assessment
Presence of a blinded examiner Comparability of age and gender between the celiac patients and healthy individuals

Strategy for data synthesis
The Mantel-Haenszel with random effects using odds ratio will be applied.

Analysis of subgroups or subsets
Children and adults
Gilles Pialoux
Creators: name: Leibowitch, Jacques (1942-2020)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: 1 fichier (2 pages)
description: Autres destinataires : Jean-Claude Melchior, Pierre-Marie Girard, Roland Landman, Dominique Mathez, Pierre Sonigo, Claude Capelier
Comparing Alkaline Phosphatase PhoX-Encoding Genes in Two Contrasting Habitats of the Large Eutrophic Lake Taihu, China
Creators: name: Dai, Jiangyu
name: Gao, Guang
name: Wu, Shiqiang
name: Wu, Xiufeng
name: Tang, Xiangming
name: Shao, Keqiang
name: Xue, Wanyun
name: Yang, Qianqian
name: Chen, Dan
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: River mouth areas of eutrophic lakes have frequent cyanobacterial blooms and high organophosphate mineralization rates. To determine the genetic background of the high organophosphate mineralization rate in river mouth areas of eutrophic lakes, we compared the diversity and abundance of bacterial alkaline phosphatase PhoX-encoding genes in the river mouth areas and the lake center within the large eutrophic Lake Taihu, China. Results showed that the seasonal average values of phosphorus content, bacterial alkaline phosphatase activity, diversity, and abundance of bacterial phoX in the river mouths were significantly higher than those in the lake center, and 47% of all identified genotypes were present only in the river mouths. The genotypes most similar to alphaproteobacterial phoX dominated in both regions, with 72% and 64% of the total genotypes in the lake center and river mouths, respectively. More than 40% of the total phoX genotypes were only found in the river mouths, however, indicating the special microbial nature in this hypereutrophic habitat. The differences in contents of dissolved organic carbon and phosphorus were related to the divergences of bacterial phoX genotypes in these two contrasting habitats. Because some dominant genotypes most similar to phoX genes of alphaproteobacterial genus were observed only in the river mouth areas, such as Microvirga sp. WSM3557, and because the hydraulic retention time of Lake Taihu is insufficient to shape the special bacterial groups in the river mouths, allochthonous inputs of nutrients and bacterial species could make contributions to explain the different organophosphate mineralization rates in these two contrasting habitats of the large eutrophic lake.
Numerical solution of the mass continuity equation for snowpack modeling on moving meshes: Coupling between mechanical settling and water vapor transport
Creators: name: Simson, Anna Lara
name: Kowalski, Julia
name: Löwe, Henning
Publisher: name: RWTH Aachen University
Year: 2020

description: Abstracts & presentations / EGU General Assembly 2020 EGU General Assembly 2020, EGU2020, online, 4 May 2020 - 8 May 2020; Göttingen : Copernicus Gesellschaft mbH EGU2020-10629, 2 Seiten (2020). doi:10.5194/egusphere-egu2020-10629
description: Published by Copernicus Gesellschaft mbH, Göttingen
title: Genomic DNA methylation distinguishes subtypes of human focal cortical dysplasia
Creators: name: Maxwell, Scott
name: El-Osta, Assam
name: Khurana, Ishant
Publisher: name: Monash University
Year: 2022
Subjects: subject: 60404 Epigenetics (incl. Genome Methylation and Epigenomics)
subject: FOS: Biological sciences

description: Focal cortical dysplasia (FCD) is a major cause of drug-resistant focal epilepsy in children, and the clinicopathological classification remains a challenging issue in daily practice. With the recent progress in DNA methylation–based classification of human brain tumors we examined whether genomic DNA methylation and gene expression analysis can be used to also distinguish human FCD subtypes.MethodsDNA methylomes and transcriptomes were generated from massive parallel sequencing in 15 surgical FCD specimens, matched with 5 epilepsy and 6 nonepilepsy controls.ResultsDifferential hierarchical cluster analysis of DNA methylation distinguished major FCD subtypes (ie, Ia, IIa, and IIb) from patients with temporal lobe epilepsy patients and nonepileptic controls. Targeted panel sequencing identified a novel likely pathogenic variant in DEPDC5 in a patient with FCD type IIa. However, no enrichment of differential DNA methylation or gene expression was observed in mechanistic target of rapamycin (mTOR) pathway–related genes.SignificanceOur studies extend the evidence for disease-specific methylation signatures toward focal epilepsies in favor of an integrated clinicopathologic and molecular classification system of FCD subtypes incorporating genomic methylation.
Critical assessment of pendimethalin in terms of persistence, bioaccumulation, toxicity, and potential for long-range transport
Creators: name: Vighi, Marco
name: Matthies, Michael
name: Solomon, Keith R.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Science Policy

description: Pendimethalin (PND, CAS registry number 40487-42-1) is a dinitroaniline herbicide that selectively controls broad-leaf and grassy weeds in a variety of crops and in noncrop areas. It has been on the market for about 30 yr and is currently under review for properties related to persistence (P), bioaccumulation (B), and toxicity (T) in the European Union (EU). A critical review of these properties as well as potential for long-range transport (LRT) was conducted. Pendimethalin has a geometric mean (GM) half-life of 76–98 d in agriculturally relevant soils under aerobic conditions in the lab. The anaerobic half-life was 12 d. The GM for field half-lives was 72 d. The GM half-life for sediment-water tests in the lab was 20 d and that in field aquatic cosms ranged from 45 to 90 d. From these data PND is not persistent as defined in the Annex II of EC regulation 1107/2009. The GM bioconcentration factor for PND was 1878, less than the criterion value. This was consistent with lack of biomagnification or accumulation in aquatic and terrestrial food chains. The GM no-observed-effect concentration (NOEC) value for fish was 43 µg/L, and 11 µg/L for algae. These do not trigger the criterion value for toxicity. In air, the DT50 of PND was estimated to be 0.35 d, which is well below the criterion of 2 d for LRT under the United Nations Economic Commission for Europe (UNECE) Aarhus protocol. Modeling confirmed lack of LRT. Because of its volatility, PND may be transported over short distances in air and was found in samples in local and semiremote regions; however, these concentrations are not of toxicological concern. Unlike other current-use pesticides, PND has not been found in samples from remote regions since 2000 and there is no apparent evidence that this herbicide accumulates in food chains in the Arctic.
title: A real-time study of sound change in inner-city Dublin-English over five decades
Creators: name: Thomson, Clare Louise
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: Irish English, sound change, Dublin English, inner-city children.

description: The purpose of this study is to identify variation and change in the pronunciation of Dublin’s inner-city dialect over the last fifty years, and if so, whether this involves association with or dissociation from traditional local norms (Hickey, 1999). Dublin’s inner-city has experienced notable demographic changes since the recession of the 1980s, the economic boom of the 1990s and the subsequent influx of migrants to the city, initially from returning Irish emigrants and some British, but later from other European countries (Darmody, 2011). Dublin English is known for characteristic and stable local productions of /ð/, /θ/ and /t/ e.g. water [wɒṱər], thin [tɪn], breathe [bri:d̪] and this [dɪs] (Hickey, 2004). The demographic changes to the inner-city predict the possible introduction of non-local variants for all three variables. The research question for this dissertation is: What evidence is there for sound change in local Dublin English in an area which has shown substantial demographic shifts? Specifically, to what extent is phonetic variation over time for /ð/, /θ/ and /t/ consistent with a shift away from local norms? For example, have the words mother, think and what maintained the local realisations [mʌdr], [tIŋk] and [ʍɒʔ] or, over time has there been a shift towards use of the supralocal or standard Irish English forms [mod̪ər], [t̪ɪŋk] and [ʍɒṱ]? This study analyses the speech of twenty-three recordings from inner-city Dublin school-children in 1961 and seventeen school-children and one adult in 2016 (a total of forty-one speakers). The early recordings were made by the class teacher, but have since been digitised and are well-known as Give Up Yer Aul Sins, which is a quote from one of the children and she narrates a Bible story. The more recent recordings were made by me in 2016, when I returned to the same inner-city school in Dublin to interview children of the same age. The adult speaker, now in her early sixties, was one of the children in the 1961 class, although was not one of the children recorded. Results show that over time there is maintenance of local variants, but all three apparently stable variables show a shift to pan-Irish and even some Standard English variants in the children recorded in 2016. For example, /ð/ and /θ/ show a shift from 1961 to 2016, with fewer local alveolar stops, more supralocal dental stops, and even some Standard English dental fricatives. These results are discussed in the context of the impact of mobility and dialect contact on sound change for this inner-city Dublin community.
Prof. Dr. Ed. Fischer (1861-1939)
Creators: name: Schädelin, Klaus
name: Gäumann, Ernst Albert
Publisher: name: Zentralbibliothek Zürich
Year: 1940
Subjects: subject: 920 Biografien, Genealogie, Insignien
subject: Nachruf
subject: Fischer, Eduard

description: Enth: Ansprache von Herrn Professor Pfarrer Schädelin, Bern ; Ansprache von Herrn Prof. Dr. E. Gäumann, Zürich
Entretien de Yazan Muhammad al-Aytan auprès de Nimr al-Barjas al-Fayez à propos du diwan Methqal à Um al-Amad
Creators: name: al-Aytan, Yazan Muhammad
name: al-Barjas al-Fayez, Nimr
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Source: http://www.calames.abes.fr/pub/ms/FileId-3139
description: Coverage: Um al-Amad, Jordanie
Radiation-induced G2/M arrest rarely occurred in glioblastoma stem-like cells
Creators: name: Liu, Junfeng
name: Liu, Yu
name: Xie, Tao
name: Luo, Longjun
name: Xu, Cheng
name: Gao, Qinglei
name: Shen, Lu
name: Wan, Feng
name: Lei, Ting
name: Ye, Fei
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Purpose: The purpose of this study is to systematically study the cell-cycle alterations of glioblastoma stem-like cells (GSLCs) after irradiation, possibly enriching the mechanisms of radioresistance of GSLCs. Materials and methods: GSLCs were enriched and identified, and then the radioresistance of GSLCs was validated by analyzing cell survival, cell proliferation, and radiation-induced apoptosis. The discrepancy of the cell-cycle distribution and expression of cell-cycle-related proteins between GSLCs and glioblastoma differentiated cells (GDCs) after irradiation was completely analyzed. Results: The survival fractions and the cell viabilities of GSLCs were significantly higher than those of GDCs after irradiation. Radiation-induced apoptosis was less prominent in GSLCs than in GDCs. After irradiation with high-dose X-rays, the percentages of GDCs in G2/M phase was evidently increased. However, radiation-induced G2/M arrest occurred less frequently in GSLCs, but S-phase arrest occurred in GSLCs after irradiation with 8 Gy. Further mechanistic studies showed that the expressions levels of Cdc25c, Cdc2, and CyclinB1 in GSLCs were not apparently changed after irradiation, while those of p-ATM and p-Chk1 were sharply increased after irradiation in GSLCs. The basal level of Cdc25c expression in GSLCs was much higher than that in GDCs. Conclusions: We explored the cell-cycle alterations and cell-cycle-related proteins expression levels in GSLCs after irradiation, providing a novel mechanism of radioresistance of GSLCs.
title: Queer themes in the Book of Jonah and its contemporary analogues
Creators: name: Ross, Samuel J.
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: Jonah, Biblical Studies, Queer, Queer reading, Bible and literature, Bible and culture, Hebrew Bible.

description: This thesis aims to produce a queer reading of the book of Jonah, focusing on themes of loneliness, abuse, and oppression. This is achieved through the construction of an interdisciplinary methodology which combines literary biblical interpretation, queer theory, and sociological research on the experiences of LGBT+ people. The thesis also brings the biblical text into conversation with artefacts of queer culture dating from the twentieth and twenty-first centuries in order to form a reflexive dialogue which illuminates both queer experience and the biblical narrative itself. In doing so, this thesis is intended to demonstrate that queer ways of being can be seen represented in biblical texts, even when the texts do not explicitly depict queer characters.
Supplementary Material for: Human Birth Weight and Reproductive Immunology: Testing for Interactions between Maternal and Offspring KIR and HLA-C Genes
Creators: name: Clark, M.M.
name: Chazara, O.
name: Sobel, E.M.
name: Gjessing, H.K.
name: Magnus, P.
name: Moffett, A.
name: Sinsheimer, J.S.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Background/Aims: Maternal and offspring cell contact at the site of placentation presents a plausible setting for maternal-fetal genotype (MFG) interactions affecting fetal growth. We test hypotheses regarding killer cell immunoglobulin-like receptor (KIR) and HLA-C MFG effects on human birth weight by extending the quantitative MFG (QMFG) test. Methods: Until recently, association testing for MFG interactions had limited applications. To improve the ability to test for these interactions, we developed the extended QMFG test, a linear mixed-effect model that can use multi-locus genotype data from families. Results: We demonstrate the extended QMFG test's statistical properties. We also show that if an offspring-only model is fit when MFG effects exist, associations can be missed or misattributed. Furthermore, imprecisely modeling the effects of both KIR and HLA-C could result in a failure to replicate if these loci's allele frequencies differ among populations. To further illustrate the extended QMFG test's advantages, we apply the extended QMFG test to a UK cohort study and the Norwegian Mother and Child Cohort (MoBa) study. Conclusion: We find a significant KIR-HLA-C interaction effect on birth weight. More generally, the QMFG test can detect genetic associations that may be missed by standard genome-wide association studies for quantitative traits.
title: The biochemical and biophysical characterisation of protein antibiotics targeting Pectobacterium spp. and Streptococcus agalactiae
Creators: name: Thompson, Catriona M.A.
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: Pectobacterium, Streptococcus, bacteriocins, uptake of bacteriocins, FusA, FusB, pectocins, zoocin, agalacticin.

description: Food security is the idea by which a population has enough food to sustain itself without famine. A large number of factors can influence the stability of food production, including diseases caused by microorganisms. Pectobacterium spp. is one of the leading causes of soft rot disease, resulting in crop losses both pre- and post-harvest. Bacteriocins are potent narrow spectrum protein antibiotics which target closely related bacteria to the producing strain. Ferredoxin-containing bacteriocins produced by and targeted towards Pectobacterium species have both a different domain organisation and uptake mechanism to all known Gram-negative bacteriocins. This work has shown that pectocins are able to pass through the outer membrane of Pectobacterium spp. by parasitising the ferredoxin uptake receptor, FusA. This uptake requires the pectocins to be flexible in order to pass through the lumen of the barrel and enter the periplasm. This work has shown an interaction between FusB and pectocin M1, suggesting a novel mechanism of uptake. Streptococcus agalactiae is the causative agent of disease in a wide range of hosts, ranging from human neonates to farmed Tilapia. S. agalactiae infection has a detrimental effect on the dairy industry each year as it is the leading cause of mastitis in cattle. As well as this, the prevalence of S. agalactiae in farmed fish has resulted in large numbers of infected fish and subsequently the infection of consumers. Bacteriocins produced by Gram-positive bacteria are often small modified peptides which target the peptidoglycan layer or cytoplasmic membrane of the target cell. However, a small number of protein bacteriocins produced by Gram-positive bacteria have been discovered, with the best characterised of these being lysostaphin. It has been shown that bacteriocins similar to lysostaphin are also produced by other Gram-positive bacteria, such as zoocin A produced by Streptococcus zooepidemicus. Prior to this work a novel protein bacteriocin produced by and targeted towards S. agalactiae, named agalacticin A, was discovered. It was predicted that this bacteriocin was similar in structure and function to zoocin A. This work has gone some way to structurally characterising agalacticin A, showing a two-domain structure joined by a flexible linker region allowing for the two domains to move independently. As well as this it has shown the importance of the histidine residues at the predicted active site confirming the similarities between agalacticin A and zoocin A. Together this work has gone some way to showing the potential of agalacticin A as a novel therapeutic. Altogether this work has characterised three novel bacteriocins active against pathogenic bacteria to gain a better understanding of their structure, mechanism of action and uptake.
Polarizable atomic multipole-based force field for DOPC and POPE membrane lipids
Creators: name: Chu, Huiying
name: Peng, Xiangda
name: Li, Yan
name: Zhang, Yuebin
name: Min, Hanyi
name: Li, Guohui
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Plant Biology
subject: Computational Biology

description: A polarizable atomic multipole-based force field for the membrane bilayer models 1,2-dioleoyl-phosphocholine (DOPC) and 1-palmitoyl-2-oleoyl-phosphatidylethanolamine (POPE) has been developed. The force field adopts the same framework as the Atomic Multipole Optimized Energetics for Biomolecular Applications (AMOEBA) model, in which the charge distribution of each atom is represented by the permanent atomic monopole, dipole and quadrupole moments. Many-body polarization including the inter- and intra-molecular polarization is modelled in a consistent manner with distributed atomic polarizabilities. The van der Waals parameters were first transferred from existing AMOEBA parameters for small organic molecules and then optimised by fitting to ab initio intermolecular interaction energies between models and a water molecule. Molecular dynamics simulations of the two aqueous DOPC and POPE membrane bilayer systems, consisting of 72 model molecules, were then carried out to validate the force field parameters. Membrane width, area per lipid, volume per lipid, deuterium order parameters, electron density profile, etc. were consistent with experimental values.
Additional file 1: of Real life patterns of care and progression free survival in metastatic renal cell carcinoma patients: retrospective analysis of cross-sectional data
Creators: name: Maroun, Rana
name: Mitrofan, Laura
name: Benjamin, Laure
name: Nachbaur, Gaelle
name: Maunoury, Franck
name: Le Jeunne, Philippe
name: Durand-Zaleski, Isabelle
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Plant Biology
subject: FOS: Biological sciences

description: Figure S1. Flow chart of included patients. Table S2. Table resuming patients â characteristics. Table S3. Table resuming adverse event data by first-line treatment. (DOCX 37 kb)
Additional file 1: of Protracted immune disorders at one year after ICU discharge in patients with septic shock
Creators: name: RichĂŠ, Florence
name: Chousterman, Benjamin
name: Valleur, Patrice
name: Mebazaa, Alexandre
name: Launay, Jean-Marie
name: Gayat, Etienne
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health
subject: Virology

description: Details on biomarker clusters. Table S1. Four clusters of circulating mediators of immune response. Table S2. Correlation between biomarkers at 1Â year and SOFA score at admission. (DOCX 60 kb)
МИЛЛИЙ ХАВФСИЗЛИК КОНТЕКСТИДА СЕКУЛЯРИЗМ СИЁСАТИ АСОСИДА АХБОРОТ ХАВФСИЗЛИГИНИ ТАЪМИНЛАШ МАСАЛАЛАРИ
Creators: name: Мамаджанов, Алишер
Publisher: name: Zenodo
Year: 2024

description: Ушбу мақолада миллий хавфсизлик контекстида секуляризм сиёсати асосида ахборот хавфсизлигини таъминлаш масалалари таҳлил қилинган.
MOESM1 of Ginsenoside G-Rh2 synergizes with SMI-4a in anti-melanoma activity through autophagic cell death
Creators: name: Lv, Da-lun
name: Chen, Lei
name: Ding, Wei
name: Zhang, Wei
name: Wang, Heâli
name: Wang, Shuai
name: Liu, Wen-bei
Publisher: name: figshare
Year: 2018
Subjects: Medicine
Cell Biology
Molecular Biology
Biological Sciences not elsewhere classified
Developmental Biology
Cancer

description: Additional file 1. The Minimum Standards of Reporting Checklist.
Additional file 1: of The HNF1α-regulated lncRNA HNF1A-AS1 reverses the malignancy of hepatocellular carcinoma by enhancing the phosphatase activity of SHP-1
Creators: name: Ding, Chen-Hong
name: Yin, Chuan
name: Chen, Shi-Jie
name: Wen, Liang-Zhi
name: Ding, Kai
name: Lei, Shu-Juan
name: Liu, Jin-Pei
name: Wang, Jian
name: Chen, Kai-xian
name: Jiang, Hua-liang
name: Zhang, Xin
name: Luo, Cheng
name: Xie, Wei-Fen
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Figure S1. Identification of HNF1α-regulated lncRNAs. Figure S2. HNF1α directly binds to the promoter region of HNF1A-AS1. Figure S3. HNF1A-AS1 suppresses the malignancy of HCC cells. Figure S4. Enforced expression of HNF1A-AS1 suppresses tumourigenicity and metastasis of MHCC-LM3 cells. Figure S5. The correlation analysis between the expression levels of SHP-1 and HNF1α or HNF1A-AS1 levels in human HCC tissues. Figure S6. HNF1α and HNF1A-AS1 do not regulate the expression of SHP-1 in human HCC cells. Figure S7. Reduction of HNF1α predicts poor prognosis of patients. Table S1. Oligonucleotides used in real-time PCR, cloning and knockdown studies. Primer sequences for real-time PCR. Table S3. Binding motif of lncRNA promoter regions for HNF1α RE. (PDF 2800 kb) (PDF 15484 kb)
title: Regulation of p53 by catalytically-inactive MDM2 mutants
Creators: name: Nomura, Koji
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: MDM2, p53, ubiquitin.

description: MDM2-MDMX complexes bind to p53, inhibiting the p53 transcriptional activity and targeting p53 for proteasomal degradation. Uncoupling p53 from MDM2 is therefore an attractive strategy to treat cancers that retain wild type p53. Small molecules that inhibit MDM2 binding to p53 release p53 from control by MDM2. While such inhibitors efficiently activate a p53 response, clinical trials have revealed that the therapeutic utility of these compounds is limited by on-target toxicities. I have therefore explored alternative mechanisms to therapeutically target MDM2, based on the hypothesis that inhibition of the MDM2 RING domain would lead to different outcomes than inhibition of the MDM2-p53 interaction. Using our crystal structure of E2 (UbcH5b)–ubiquitin-MDM2RING-MDMXRING complex as a starting point, MDM2 mutants that prevent E2–ubiquitin binding were designed. MDM2 mutants that are unable to interact with E2–ubiquitin complex have lost their E3 ligase activity including the ability to ubiquitinate p53, despite retaining the ability to bind to p53, homo-dimerise and hetero-dimerise with MDMX. As a result, p53 protein accumulates in cells expressing these catalytically-inactive MDM2 mutants. However, the E2–ubiquitin non-binding MDM2 mutants retain the ability to limit p53 transcriptional activity under normal unstressed condition, despite the elevated p53 levels. As a result, cells can proliferate normally, but show a more robust induction of p53 activity in response to stress. These observations suggest that the direct inhibition of E3 activity of MDM2 may be less deleterious to normal cells than inhibition of the MDM2-p53 interaction. To test this, the development of novel in vivo models based on conditional knock-in of one of the MDM2 mutants identified in this study was initiated. Based on preliminary data, mice expressing these mutants are expected to be developmentally normal but less tumour prone due to an increased sensitivity to p53 activation. This study provides mechanistic insight that will help in the development of novel inhibitors that targeting MDM2 while avoiding the on-target toxicities showed in the clinic by currently available MDM2 inhibitors.