cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Assistive technologies in reducing caregiver burden among informal caregivers of older adults: a systematic review
Creators: name: Keshini Madara Marasinghe
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Aim: The world population is rapidly ageing. As population age, the incidence of functional limitations increases, demanding higher levels of care from caregivers. Assistive technologies improve individuals’ functioning, independence, well-being and quality of life. By increasing independence of older adults, assistive technologies decrease workloads required from informal caregivers. This review investigates, evaluates, and synthesises existing findings to examine whether and how assistive technologies reduce caregiver burden. Methods: Databases searched included MEDLINE, EMBASE, Scopus, and Cochrane Library. Three groups of keywords were combined: those relating to assistive technology, caregiver burden, and older adults. Results: Two theories emerged from the analysis of study results. Caregivers reported that assistive technologies decrease caregiver burden. However, caregivers had concerns that assistive technologies could add to caregiver burden, highlighting the limitations of assistive technology. Conclusions: As suggested by a majority of the studies in this review, assistive technologies contribute to reducing caregiver burden among caregivers of older adults. Assistive technologies assisted caregivers by reducing time, levels of assistance and energy put towards caregiving, anxiety and fear, task difficulty, safety risk particularly for activities requiring physical assistance and increasing the independence of the users. Further research is required to better understand limitations of assistive technologies.Implications for RehabilitationSupport for informal caregivers of older adults need more attention and recognition.Assistive technologies can reduce caregiver burden among informal caregivers of older adults.Further research is required to better understand the effectiveness of assistive technologies in reducing caregiver burden as well as limitations and barriers associated with using assistive technologies. Support for informal caregivers of older adults need more attention and recognition. Assistive technologies can reduce caregiver burden among informal caregivers of older adults. Further research is required to better understand the effectiveness of assistive technologies in reducing caregiver burden as well as limitations and barriers associated with using assistive technologies.
Conscience Issue Tracker - April 2025
Creators: name: Prouse, Chantal
name: Tyhurst, Charlotte
name: Jolicoeur-Becotte, Marie
name: Bechthold, Kristina
name: Miksza, Jerod
name: Lamberti, Dylan
name: Barclay, Christophe
name: Gold, E. Richard
Publisher: name: Conscience
Year: 2025

description: Conscience Issue Tracker - March 2025

Issues in this edition:

Pharma companies expected to absorb any tariff hit in short term

Pharma companies collaborate on secure data sharing for AI

Simon Fraser University Implements Open Scholarship University-Wide

Pharmaceutical industry worries about FDA delays
Convex Optimization and Feasible Circulant Matrix Embeddings in Synthesis of Stationary Gaussian Fields
Creators: name: Helgason, Hannes
name: Kechagias, Stefanos
name: Pipiras, Vladas
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Circulant matrix embedding is one of the most popular and efficient methods for the exact generation of Gaussian stationary univariate series. Although the idea of circulant matrix embedding has also been used for the generation of Gaussian stationary random fields, there are many practical covariance structures of random fields where classical embedding methods break down. In this work, we propose a novel methodology that adaptively constructs feasible circulant embeddings based on convex optimization with an objective function measuring the distance of the covariance embedding to the targeted covariance structure over the domain of interest. The optimal value of the objective function will be zero if and only if there exists a feasible embedding for the a priori chosen embedding size.
A double-blind, randomized clinical study to determine the efficacy of benzocaine 10% on histamine-induced pruritus and UVB-light induced slight sunburn pain
Creators: name: Bauer, Martin
name: Schwameis, Richard
name: Scherzer, Thomas
name: Lang-Zwosta, Isabelle
name: Nishino, Kanako
name: Zeitlinger, Markus
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Cancer
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Biotechnology
subject: Pharmacology
subject: Physiology
subject: Neuroscience
subject: Cell Biology
subject: Microbiology

description: Introduction: This study aims to explore the efficacy of the topical application of 10% benzocaine for treating pruritus and pain as compared to vehicle ointment. Methods: Twenty male subjects were treated in a randomized double-blind fashion with the investigational medicinal product (IMPD) and vehicle. Immediately after the injection of 100 µg histamine on both arms, subjects received topical treatment and pruritus was subsequently assessed with visual analogue scale (VASpruritus) and Eppendorfer questionnaire. Ultraviolet B radiation (UVB) was administered on the back to induce slight sunburn. Twelve hours after UVB application again the IMPD was applied on the right or left upper back and vehicle on the other side and pain related to sunburn was measured with VASpain and pressure algometry. Results: A trend towards better reduction of pruritus was shown for benzocaine in VASpruritus. For the VASpain significant differences in group comparison (p = 0.02) were observed. Algometer measurements showed onset of pain reduction in the verum group after 20 min whereas in the vehicle-treated area pain relief occurred only after 60 min after application. Conclusions: The topically administered ointment containing 10% benzocaine was found superior over vehicle for treating pain, but not pruritus.
I-band photometry of the quiescent black hole X-ray nova GROJ0422+32=V518 Per: modelling of the orbital light curve and estimation of the black hole mass
Creators: name: Cherepashchuk, A.
name: Khruzina, T.
name: Atapin, K.
Publisher: name: arXiv
Year: 2024
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present new photometric observations of the X-ray nova GROJ0422+32 (V518 Per) carried out in the I$_c$ band over 14 nights in 2020 -- 2023. We had to revise the orbital period of the system, the new value $P_{\rm orb}=5^{\rm h}04^{\rm m}35.50^{\rm s} \pm 0.04^{\rm s}$ is about one minute shorter than the period by Webb et al. (2000) but close to the result reported earlier by Filippenko et al. (1995). The obtained folded light curve has a regular shape with a clear ellipticity effect and signatures of a slight heating effect. The simulations of this light curve in terms of the model of an interacting binary system allowed us to estimate the orbital inclination $i = 33^\circ - 49^\circ$ of the system and derive masses of the black hole $M_x=(6.5\pm2.9)M_\odot$ and companion star $M_v=(0.47\pm0.21)M_\odot$. This range of the black hole masses overlaps with the known gap of (2--5)\,M$_\odot$ in the distribution of compact objects masses but mostly it lies above the upper boundary of this gap. To obtain more precise estimates one needs to know the degree of heating of the donor star, so synchronous X-ray/optical observations of this system are desirable.
description: 13 pages, 10 figures, 5 tables, accepted for publication in MNRAS
AMPERE Deliverable report D7.6 "Education & training: module full scale automated pilot line"
Creators: name: Colletti, Claudio
name: Ragonesi, Antonino
Publisher: name: Zenodo
Year: 2020
Subjects: Photovoltaic
Heterojunction
PV Manufacturing
Renewable Energy

description: The present deliverable is reporting all the activities and presentations done during Second AMPERE HJT School held in Catania in October, the 8th, 9th, 10th 2019. EGP opened its Catania Manufacturing Line and Laboratories facilities to the world of education (students) and industry (workers) to show and train to the HJT for future employees of the HJT. Focus of this School was put on manufacturing automation and operations, on HJT Assembly technology and on HJT Module reliability, giving evidence also on main components behaviour. Moreover, informations on HJT 1GW Fab financial feasibility and on Solar Systems simulation and performances has been presented. All the presentations are available on AMPERE Project Repository at the following link: http://www.ampere-h2020.eu/ .
An overview of thirty years of research on ballast water as a vector for aquatic invasive species to freshwater and marine environments
Creators: name: Bailey, Sarah A.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences

description: Ballast water has been widely used by commercial vessels to control trim, draft and stability since the late 1870s. While the global transport of ballast water (and associated sediments) was first recognized as a potential dispersal mechanism for plankton in the late 1890s, quantitative research on the issue does not appear in the primary scientific literature until the mid-1980s. Following James T. Carlton's comprehensive review of the biology of ballast water in 1985, there was an explosion in research effort, with nearly 400 papers published in the last thirty years. This article provides a brief overview of the role that ballast water has played as a global vector for aquatic invasive species, summarizing the current state of ballast water research and emerging topics for future study, based on a review of articles in the primary scientific literature.Initially, the main research focus was to document the community composition of ballast water in ships arriving to ports around the world. In the late 1990s, risk ssessments examining shipping traffic patterns and environmental tolerances of species likely transported in ballast water dominated. By 2000, ballast water studies examining efficacy of various treatment strategies dominated, and papers exploring new tools and methods for more accurate/representative sampling and analysis of ballast water emerged as an important research topic. There is currently insufficient data to confidently quantify the probability of invasion associated with any particular inoculum density (or discharge standard), as a result, laboratory, field and modeling studies examining the relationship between invasion risk and the size of the initially released population (the ‘risk-release relationship’) are an emerging, high priority field of study.
Convex optimization and feasible circulant matrix embeddings in synthesis of stationary Gaussian fields
Creators: name: Helgason, Hannes
name: Pipiras, Vladas
name: Kechagias, Stefanos
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Biotechnology

description: Circulant matrix embedding is one of the most popular and efficient methods for the exact generation of Gaussian stationary univariate series. Although the idea of circulant matrix embedding has also been used for the generation of Gaussian stationary random fields, there are many practical covariance structures of random fields where classical embedding methods break down. In this work, we propose a novel methodology which adaptively constructs feasible circulant embeddings based on convex optimization with an objective function measuring the distance of the covariance embedding to the targeted covariance structure over the domain of interest. The optimal value of the objective function will be zero if and only if there exists a feasible embedding for the a priori chosen embedding size.
Additional file 1 of Dynamic monitoring soft tissue healing via visualized Gd-crosslinked double network MRI microspheres
Creators: name: Chen, Tongtong
name: Cai, Zhengwei
name: Zhao, Xinxin
name: Wei, Gang
name: Wang, Hanqi
name: Bo, Tingting
name: Zhou, Yan
name: Cui, Wenguo
name: Lu, Yong
Publisher: name: figshare
Year: 2024
Subjects: Biophysics
Biochemistry
Space Science
Physical Sciences not elsewhere classified
Medicine
Cell Biology
Molecular Biology
Biotechnology
Chemical Sciences not elsewhere classified
Science Policy
Cancer
Computational Biology

description: Supplementary Material 1
Number of Food-Insecure People in Selected Low- and Middle-Income Countries Projected To Fall 45 percent Over Next Decade
Creators: name: Meade, Birgit
name: Meade, Birgit
Publisher: name: Unknown
Year: 2019
Subjects: subject: Consumer/Household Economics
subject: Financial Economics
subject: Food Consumption/Nutrition/Food Safety
subject: Food Security and Poverty
subject: Health Economics and Policy
subject: global
subject: food-insecure
subject: food security
subject: low income
subject: middle income
subject: Food Security Assessment (IFSA)

description: The share of food-insecure people in the 76 low- and middle-income countries is projected to fall from 19.3 percent in 2019 to 9.2 percent in 2029. The number of food-insecure people is projected to fall markedly, 45 percent, which is faster than the decline in the intensity of food insecurity, at the aggregate level. Related Topics: Global food security Alt Text:
STUDIO CLINICO_E -LUTECH 363.2019
Creators: name: Data Management
Publisher: name: Zenodo
Year: 2024

description: TITOLO : E-LUTECH Studio osservazionale sull’Efficacia a LUngo TErmine della CHirurgia periperidrosi focale primaria

Promotore: MultiMedica

Studio osservazionale prospettico monocentrico

Protocollo Versione 1.0  del 13/3/2019- Verbale CE 30.2019 e 47.2019
title: 03_0218
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Additional file 1 of A SU6668 pure nanoparticle-based eyedrops: toward its high drug Accumulation and Long-time treatment for corneal neovascularization
Creators: name: Wu, Han
name: Ye, Jinfa
name: Zhang, Minjie
name: Zhang, Lingyu
name: Lin, Sijie
name: Li, Qingjian
name: Liu, Yanbo
name: Han, Yun
name: Huang, Caihong
name: Wu, Yiming
name: Cheng, Yuhang
name: Cai, Shundong
name: Ke, Lang
name: Liu, Gang
name: Li, Wei
name: Chu, Chengchao
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer

description: Supplementary Material 1
Historical cohort analysis of treatment patterns for patients with type 2 diabetes initiating metformin monotherapy
Creators: name: Hazel-Fernandez, Leslie
name: Yihua Xu
name: Moretz, Chad
name: Meah, Yunus
name: Baltz, Jean
name: Lian, Jean
name: Kimball, Edward
name: Bouchard, Jonathan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: To describe treatment regimen changes of patients with type 2 diabetes mellitus (T2DM) initiating metformin monotherapy, and assess factors associated with those changes 12 months post-initiation. Retrospective cohort analysis of medical, pharmacy and laboratory claims of 17,527 Medicare Advantage (MAPD) Humana members aged 18–89, who had ≥1 medical claim with primary diagnosis or ≥2 medical claims with secondary diagnosis of T2DM (ICD-9-CM code 250.x0 or 250.x2) who filled an initial prescription for metformin (GPI code 2725) between 1 January 2008 and 30 September 2011. The main outcome measure was change in metformin monotherapy during the 12 months following initiation. Factors associated with treatment changes during follow-up were examined using Cox proportional hazards regression models. Fifty-nine percent of patients (mean age 69.6 years) remained on metformin monotherapy with no changes. Discontinuation was the most common treatment change (33%), followed by addition (5%), and switching (2%) to other antidiabetics. Of patients who discontinued treatment (median time to discontinuation = 90 days), 61% did not reinitiate any diabetic treatment during the follow-up period. Among patients who added or switched to other antidiabetics, sulfonylureas were the most common addition or replacement agent. Predictors of discontinuation were being female, Black or Hispanic, low-income subsidy eligible, having higher initial out-of-pocket metformin costs, or a diagnosis of depression. Discontinuation was less likely during follow-up if patients had higher pre-index pill burdens or records of a pre-index A1C screening test. A higher risk of discontinuation was observed for patients with low baseline A1C. One study limitation was that exact discontinuation dates could not be determined using claims. The findings suggest that gender, race, ethnicity, depression, and low income status were contributory factors to metformin discontinuation. More intensive monitoring and treatment adjustments may be warranted for patients newly initiated on metformin. This could ultimately improve morbidity, mortality, and costs associated with poor glycemic control.
title: Chronic osteomyelitis with bone sequestrum and cutaneous fistula in a previous femur fracture
Creators: name: Pinto, Ana Luísa
Publisher: name: EURORAD
Year: 2024
Subjects: subject: Musculoskeletal system
subject: Musculoskeletal bone
subject: Paediatric
subject: Conventional radiography
subject: CT
subject: MR
subject: Diagnostic procedure
subject: Abscess
subject: Demineralisation-Bone
subject: Infection
subject: Clinical Case

description: Clinical History: A 15-year-old boy born in West Africa with a left femur fracture 1 year ago, treated conservatively with casting immobilisation, is now admitted to the hospital with leg pain and purulent cutaneous drainage. Blood tests revealed high c-reactive protein and erythrocyte sedimentation rate, and exudate culture revealed meticillin-susceptible Staphylococcus aureus.

description: 15 years, male
Setaphyes kielensis
Creators: name: Neuhaus, Birger
name: Lu, Borong
name: Yamasaki, Hiroshi
name: González-Casarrubios, Alberto
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Kinorhyncha
Allomalorhagida
Pycnophyidae
Setaphyes
Setaphyes kielensis

description: Infestation of Setaphyes kielensis
In the material collected in May 1998, 27 out of 69 specimens of Setyphyes kielensis (= 39 %) were infested by 106 specimens of Trematosoma husselae sp. nov. (Table 2). A kinorhynch hosted 1– 15 specimens of suctorian ciliates, on average 4 specimens (Table 2). The vast majority occurred on the ventral side of the basibionts (80 %): the rate attached to the ventral side of basibionts was particularly high on segment 1 (19 % of all attached T. husselae sp. nov.), segment 3 (12 %), and on segments 8 and 9 (8–9 %). Neither Cothurnia buetschlii nor filamentous bacteria were found on the kinorhynchs collected in 1998.
In the material collected in June 2016, 202 specimens of Trematosoma husselae sp. nov. were found on 20 out of 23 S. kielensis mounted for light microscopy and 397 ciliates on 21 specimens mounted for SEM, in total 599 specimens (Tables 3, 4). It should be kept in mind that the kinorhynchs were mounted with one side (usually the lateral side) on the SEM stub, so potential epibionts on this side could not be observed, and the number of epibionts might be slightly higher (Table 3). One kinorhynch revealed no epibionts (ZMB 12455, SEM). It was extremely dirty and may have been dead at the time of collecting, therefore, it was excluded from the further analysis.
A kinorhynch collected in June 2016 hosted 1– 43 specimens of Trematosoma husselae sp. nov., on average 15 specimens (Tables 3, 4). Most epibionts concentrated on the ventral side of their basibionts (82 %) and here especially on segment 1 (17 % of basibionts) and on segments 8–10 (11–13 %; Tables 3, 4). Only 5 % of T. husselae sp. nov. occurred on segment 2, whereas the remaining segments revealed a balanced distribution of 7–9 %. A single suctorian epibiont was found on segment 11 of a single kinorhynch.
Nine specimens of Cothurnia buetschlii were found on five S. kielensis out of 24 specimens mounted for light microscopy and five specimens on two kinorhynchs out of 21 specimens mounted for SEM (ZMB 12486–12489, 12468, 12499; Figs 7–9; Tables 3, 4).
Filamentous prokaryote epibionts occurred in 18 out of 42 specimens of S. kielensis, not all of them carrying ciliate epibionts (Tables 3, 4). A species of coccoid prokaryotes arranged in a row was traced only once (ZMB 12486; Fig. 5J; Table 4).
description: Published as part of Neuhaus, Birger, Lu, Borong, Yamasaki, Hiroshi & González-Casarrubios, Alberto, 2023, Epibiontic life on intertidal Setaphyes kielensis and S. dentatus (Kinorhyncha, Pycnophyidae) from Sylt, North Sea, Germany, with a description of a new species of Trematosoma (Ciliophora, Acinetidae) and a redescription of Cothurnia buetschlii (Ciliophora, Vaginicolidae), pp. 439-470 in Zootaxa 5343 (5) on pages 456-460, DOI: 10.11646/zootaxa.5343.5.2, http://zenodo.org/record/8345479
Interaction of a tyrosine kinase inhibitor, vandetanib with human serum albumin as studied by fluorescence quenching and molecular docking
Creators: name: Md. Zahirul Kabir
name: Shevin R. Feroz
name: Mukarram, Abdul Kadir
name: Zazali Alias
name: Saharuddin B. Mohamad
name: Tayyab, Saad
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Pharmacology
subject: Molecular Biology
subject: Cell Biology
subject: Medicine
subject: Physics
subject: Biochemistry
subject: Biophysics

description: Interaction of a tyrosine kinase inhibitor, vandetanib (VDB) with the major transport protein in the human blood circulation, human serum albumin (HSA) was investigated using fluorescence spectroscopy, circular dichroism spectroscopy and molecular docking analysis. The binding constant of the VDB-HSA system, as determined by fluorescence quenching titration method was found in the range, 8.92-6.89 × 103 M−1 at three different temperatures, suggesting moderate binding affinity. Furthermore, decrease in the binding constant with increasing temperature revealed involvement of static quenching mechanism, thus affirming the formation of the VDB-HSA complex. Thermodynamic analysis of the binding reaction between VDB and HSA yielded positive ΔS (52.76 J mol−1 K−1) and negative ΔH (-6.57 kJ mol−1) values, which suggested involvement of hydrophobic interactions and hydrogen bonding in stabilizing the VDB-HSA complex. Far-UV and near-UV CD spectral results suggested alterations in both secondary and tertiary structures of HSA upon VDB binding. Three-dimensional fluorescence results also showed significant microenvironmental changes around the Trp residue of HSA consequent to the complex formation. Use of site-specific marker ligands, such as phenylbutazone (site I marker) and diazepam (site II marker) in competitive ligand displacement experiments indicated location of the VDB binding site on HSA as Sudlow’s site I (subdomain IIA), which was further established by molecular docking results. Presence of some common metal ions, such as Ca2+, Zn2+, Cu2+, Ba2+, Mg2+ and Mn2+ in the reaction mixture produced smaller but significant alterations in the binding affinity of VDB to HSA.
title: Transcription du manuscrit de Semur-en-Auxois, Bibliothèque Municipale, ms. 1, p. 28
Creators: name: Aubert, Eduardo Henrik
name: Brochard, Pierre
name: Aubert, Eduardo Henrik
name: Brochard, Pierre
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: subject: Laboratoire de médiévistique occidentale de Paris
subject: Semur-en-Auxois
subject: LaMOP

description: Transcription du manuscrit de Semur-en-Auxois, Bibliothèque Municipale, ms. 1, p. 28

production-software: eScriptorium + Kraken version 3.0.13 (PageXml)
description: Source: https://www.nakala.fr/10.34847/nkl.35ca4gnm
description: Source: https://www.nakala.fr/10.34847/nkl.e905tdea
description: Relation: https://lamop.hypotheses.org/
description: Transcription du manuscrit Semur-en-Auxois, Bibliothèque Municipale, ms. 1
description: Transcription du manuscrit Semur-en-Auxois, Bibliothèque Municipale, ms. 1
Variability in decision-making and critical cue use by different road users at rail level crossings
Creators: name: Beanland, Vanessa
name: Lenné, Michael G.
name: Salmon, Paul M.
name: Stanton, Neville A.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Collisions at rail level crossings (RLXs) are typically high-severity and high-cost, often involving serious injuries, fatalities and major disruptions to the transport network. Most research examining behaviour at RLXs has focused exclusively on drivers and consequently there is little knowledge on how other road users make decisions at RLXs. We collected drivers’, motorcyclists’, bicyclists’ and pedestrians’ self-reported daily experiences at RLXs for two weeks, focusing on behaviour, decision-making and information use in the presence of a train and/or activated RLX signals. Both information use and behaviour differed between road users. Visual information (e.g. flashing lights) was more influential for motorists, whereas pedestrians and cyclists relied more on auditory information (e.g. bells). Pedestrians were also more likely to violate active RLX warnings and/or cross before an approaching train. These results emphasise the importance of adopting holistic RLX design approaches that support cognition and behaviour across for all road users. Practitioner Summary: This study explores how information use and decision-making at rail level crossings (RLXs) differ between road user groups, using a two-week self-report study. Most users make safe decisions, but pedestrians are most likely to violate RLX warnings. Information use (visual vs. auditory) also differs substantially between road user groups.
New lipoxygenase and cholinesterase inhibitory sphingolipids from Carthamus oxyacantha
Creators: name: Dilshad, Muhammad
name: Riaz, Naheed
name: Saleem, Muhammad
name: Shafiq, Nusrat
name: Ashraf, Muhammad
name: Tayaba Ismail
name: Rafiq, Hafiza Mehwish
name: Jabbar, Abdul
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Inorganic Chemistry
subject: Plant Biology
subject: FOS: Biological sciences

description: Two new sphingolipids: oxyacanthin A [(2S,3S,4R)-2-{[(2R,5E)-2-hydroxyoctadec-5-enoyl]amino}hexaeicosane-1,3,4-triol; 1] and B [(2S,3S,4R)-2-{[(2R,5E)-2-hydroxyoctadec-5-enoyl]amino}hexaeicosane-1,3,4-triol-1-O-β-D-glucopyranoside; 2], together with 1-octacosanol, β-sitosterol, β-sitosterol 3-O-β-D-glucopyranoside and luteolin 7-O-β-glucopyranoside were isolated from the methanolic extract of the whole plant of Carthamus oxyacantha. Their structures were elucidated using 1H and 13C NMR spectra and 2D NMR analyses (HMQC, HMBC and COSY) in combination with mass spectrometry (EI-MS, HR-EI-MS, FAB-MS and HR-FAB-MS) experiments and in comparison with the literature data of the related compounds. Both the compounds 1 and 2 showed inhibitory potential against lipoxygenase (LOX) in a concentration-dependent manner with IC50 values 83.3 ± 1.3 and 245.7 ± 1.1 µM, whereas compound 2 showed inhibition against enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50 values 65.3 ± 0.1 and 93.6 ± 0.1 µM, respectively.
Historical cohort analysis of treatment patterns for patients with type 2 diabetes initiating metformin monotherapy
Creators: name: Hazel-Fernandez, Leslie
name: Yihua Xu
name: Moretz, Chad
name: Meah, Yunus
name: Baltz, Jean
name: Lian, Jean
name: Kimball, Edward
name: Bouchard, Jonathan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Chemistry
subject: Biotechnology
subject: Biochemistry

description: Objective:To describe treatment regimen changes of patients with type 2 diabetes mellitus (T2DM) initiating metformin monotherapy, and assess factors associated with those changes 12 months post-initiation.Methods:Retrospective cohort analysis of medical, pharmacy and laboratory claims of 17,527 Medicare Advantage (MAPD) Humana members aged 18–89, who had ≥1 medical claim with primary diagnosis or ≥2 medical claims with secondary diagnosis of T2DM (ICD-9-CM code 250.x0 or 250.x2) who filled an initial prescription for metformin (GPI code 2725) between 1 January 2008 and 30 September 2011. The main outcome measure was change in metformin monotherapy during the 12 months following initiation. Factors associated with treatment changes during follow-up were examined using Cox proportional hazards regression models.Results:Fifty-nine percent of patients (mean age 69.6 years) remained on metformin monotherapy with no changes. Discontinuation was the most common treatment change (33%), followed by addition (5%), and switching (2%) to other antidiabetics. Of patients who discontinued treatment (median time to discontinuation = 90 days), 61% did not reinitiate any diabetic treatment during the follow-up period. Among patients who added or switched to other antidiabetics, sulfonylureas were the most common addition or replacement agent. Predictors of discontinuation were being female, Black or Hispanic, low-income subsidy eligible, having higher initial out-of-pocket metformin costs, or a diagnosis of depression. Discontinuation was less likely during follow-up if patients had higher pre-index pill burdens or records of a pre-index A1C screening test. A higher risk of discontinuation was observed for patients with low baseline A1C. One study limitation was that exact discontinuation dates could not be determined using claims.Conclusions:The findings suggest that gender, race, ethnicity, depression, and low income status were contributory factors to metformin discontinuation. More intensive monitoring and treatment adjustments may be warranted for patients newly initiated on metformin. This could ultimately improve morbidity, mortality, and costs associated with poor glycemic control.
Additional file 1 of UHPLC-HRMS-based Multiomics to Explore the Potential Mechanisms and Biomarkers for Colorectal Cancer
Creators: name: Wang, Xuancheng
name: Guan, Xuan
name: Tong, Ying
name: Liang, Yunxiao
name: Huang, Zongsheng
name: Wen, Mingsen
name: Luo, Jichu
name: Chen, Hongwei
name: Yang, Shanyi
name: She, Zhiyong
name: Wei, Zhijuan
name: Zhou, Yun
name: Qi, Yali
name: Zhu, Pingchuan
name: Nong, Yanying
name: Zhang, Qisong
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Supplementary Material 1
Variability in decision-making and critical cue use by different road users at rail level crossings
Creators: name: Beanland, Vanessa
name: Lenné, Michael G.
name: Salmon, Paul M.
name: Stanton, Neville A.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences

description: Collisions at rail level crossings (RLXs) are typically high-severity and high-cost, often involving serious injuries, fatalities and major disruptions to the transport network. Most research examining behaviour at RLXs has focused exclusively on drivers and consequently there is little knowledge on how other road users make decisions at RLXs. We collected drivers’, motorcyclists’, bicyclists’ and pedestrians’ self-reported daily experiences at RLXs for two weeks, focusing on behaviour, decision-making and information use in the presence of a train and/or activated RLX signals. Both information use and behaviour differed between road users. Visual information (e.g., flashing lights) was more influential for motorists, whereas pedestrians and cyclists relied more on auditory information (e.g., bells). Pedestrians were also more likely to violate active RLX warnings and/or cross before an approaching train. These results emphasise the importance of adopting holistic RLX design approaches that support cognition and behaviour across for all road users.Practitioner summary: This study explores how information use and decision-making at rail level crossings (RLXs) differs between road user groups, using a two-week self-report study. Most users make safe decisions, but pedestrians are most likely to violate RLX warnings. Information use (visual vs. auditory) also differs substantially between road user groups.
Additional file 1 of Insights into the origin of metazoan multicellularity from predatory unicellular relatives of animals
Creators: name: Tikhonenkov, Denis V.
name: Hehenberger, Elisabeth
name: Esaulov, Anton S.
name: Belyakova, Olga I.
name: Mazei, Yuri A.
name: Mylnikov, Alexander P.
name: Keeling, Patrick J.
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Marine Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Fig. S1. A-C – Syssomonas multiformis sucks out the cytoplasm of the prey; D – three cells of Syssomonas (s) suck out the cytoplasm of the same prey cell together, other Syssomonas cells (arrows) become attracted and swim to the same prey cell; E – unusual flagellated cell of Syssomonas containing vesicular structures; F – cells of Syssomonas with engulfed starch granules swim to the starch crystals druse and hide within the starch crystals. Fig. S2. Rice grain destruction in Petri dish with Pratt medium and presence of the cells of Parabodo caudatus (p rey) only (A) and Syssomonas multiformis (B) after 9 days of incubation.
Neutral and cationic manganese(II)–diclofenac complexes: structure and biological evaluation
Creators: name: Zampakou, Marianthi
name: Hatzidimitriou, Antonios G.
name: Papadopoulos, Athanasios N.
name: Psomas, George
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Hematology
Cancer
Biological Sciences
Chemistry
Earth and Environmental Sciences
Cell Biology
Biochemistry
Biophysics

description: The interaction of MnCl2 with the non-steroidal anti-inflammatory drug sodium diclofenac in the presence of 2,2′-bipyridine and pyridine resulted in the formation of cationic and neutral mononuclear complexes [Mn(diclofenac)(2,2′-bipyridine)(H2O)2] (diclofenac) (1) and [Mn(diclofenac)2(pyridine)2(H2O)2] (2), respectively. The structure of 1 was characterized by X-ray crystallography. In a preliminary attempt to evaluate the biological properties and possible application, the interaction of the complexes with calf-thymus DNA and human or bovine serum albumins was monitored. Additionally, the ability of the compounds to scavenge radicals such as 1,1-diphenyl-picrylhydrazyl, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), and hydroxyl radicals was evaluated; the complexes were more potent scavengers than free sodium diclofenac.
Structure, syntax and “small-world” organization in the complex songs of California Thrashers (Toxostoma redivivum)
Creators: name: Cody, Martin L.
name: Taylor, Charles E.
name: Stabler, Edward
name: Castellanos, Héctor Manuel Sánchez
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Neuroscience
subject: Physics
subject: Biochemistry

description: We describe songs of the California Thrasher (Toxostoma redivivum), a territorial, monogamous species whose complex songs are composed of extended sequences of phonetically diverse phrases. We take a network approach, so that network nodes represent specific phrases, and links or transitions between nodes describe a subgroup structure that reveals the syntax of phrases within the songs. We found that individual birds have large and largely distinct repertoires, with limited phrase sharing between neighbours and repertoire similarity decaying between individuals with distance apart, decaying also over time within individuals. During song sequences, only a limited number of phrases (ca. 15–20) were found to be actually “in play” at any given time; these phrases can be grouped into themes within which transitions are much more common than among them, a feature contributing to a small-world structure. It appears that such “small-world themes” arise abruptly, while old themes are abandoned more gradually during extended song sequences; most individual thrashers switch among 3–4 themes over the course of several successive songs, and some small-world themes appear to have specific roles in starting or ending thrasher songs.
Combinatorial anticancer effects of curcumin and sorafenib towards thyroid cancer cells via PI3K/Akt and ERK pathways
Creators: name: Junjia Zhang
name: Jichun Yu
name: Xie, Rong
name: Wanzhi Chen
name: Yunxia Lv
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Cancer
subject: Biological Sciences
subject: Chemistry
subject: Pharmacology
subject: Molecular Biology
subject: Cell Biology
subject: Medicine
subject: Biochemistry
subject: Biophysics

description: The objective of this study was to examine the in vitro combinatorial anticancer effects of curcumin and sorafenib towards thyroid cancer cells FTC133 using a MTT cytotoxicity assay, and to test whether the mechanism involves induction of apoptosis. The present results demonstrated that curcumin at 15–25 μM dose-dependently suppressed the proliferation of FTC133. Combined treatment (curcumin (25 μM) and sorafenib (2 μM)) resulted in a reduction in cell colony formation and significantly decreased the invasion and migration of FTC133 cells compared with that treated with individual drugs. Western blot showed that the levels of p-ERK and p-Akt proteins were significantly reduced (p
Additional file 1 of A cross-sectional study of SARS-CoV-2 antibodies among healthcare workers in a tertiary care hospital in Taiwan: implications for protection against the Omicron variants
Creators: name: Chen, Chang-Hua
name: Chao, Day-Yu
name: Kor, Chew-Teng
name: Kuo, Su-Feng
name: Lin, Jen-Shiou
name: Lai, Huei-Wen
name: Liu, Yen-Tze
name: Lin, Ching-Hsiung
name: Chen, Mu-Kuan
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Additional file 1: Supplement Table 1. The confusion matrix for Anti-N for SARS-CoV-2 and diagnosed with COVID-19. Supplement Table 2. The distribution of anti-S of SARS-CoV-2 among four different units. Supplement Table 3. The demography among different vaccine types. Supplement Table 4The logistic regression model to determine the association factors and COVID infection in current study. Supplement Figure 1. Timeline of different variants of concerns for SARS-CoV-2. Supplement Figure 2. Timeline of Taiwan’s COVID-19 infection prevention and control policies from 2021 to March 2023.
Bound-state relativistic quantum electrodynamics: a perspective for precision physics with atoms and molecules
Creators: name: Nonn, Ádám
name: Margócsy, Ádám
name: Mátyus, Edit
Publisher: name: arXiv
Year: 2024
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Precision physics aims to use atoms and molecules to test and develop the fundamental theory of matter, possibly beyond the Standard Model. Most of the atomic and molecular phenomena are described by the QED (quantum electrodynamics) sector of the Standard Model. Do we have the computational tools, algorithms, and practical equations for the most possible complete computation of atoms and molecules within the QED sector? What is the fundamental equation to start with? Is it still Schrödinger's wave equation for molecular matter, or is there anything beyond that? This paper provides a concise overview of the relativistic QED framework and recent numerical developments targeting precision physics and spectroscopy applications with common features with the robust and successful relativistic quantum chemistry methodology.
Neutral and cationic manganese(II)–diclofenac complexes: Structure and biological evaluation
Creators: name: Zampakou, Marianthi
name: Hatzidimitriou, Antonios G.
name: Papadopoulos, Athanasios N.
name: Psomas, George
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Hematology
Cancer
Biological Sciences
Chemistry
Earth and Environmental Sciences
Cell Biology
Biochemistry
Biophysics

description: The interaction of MnCl2 with the non–steroidal anti–inflammatory drug sodium diclofenac in the presence of 2,2′–bipyridine and pyridine resulted in the formation of cationic and neutral mononuclear complexes [Mn(diclofenac)(2,2′–bipyridine)(H2Ο)2] (diclofenac) (1) and [Mn(diclofenac)2(pyridine)2(H2O)2] (2), respectively. The structure of 1 was characterized by X-ray crystallography. In a preliminary attempt to evaluate the biological properties and possible application, the interaction of the complexes with calf–thymus DNA and human or bovine serum albumins was monitored. Additionally the ability of the compounds to scavenge radicals such as 1,1–diphenyl–picrylhydrazyl, 2,2′–azino–bis(3–ethylbenzothiazoline–6–sulfonic acid) and hydroxyl radicals was evaluated; the complexes were more potent scavengers than free sodium diclofenac.
title: Bassin minier de Djérada (extrait de carte) [Guenfouda, El Aouinet]
title: Bassin minier de Djérada (extrait de carte) [Guenfouda, El Aouinet]
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Energie
subject: Mines
subject: Bassin minier

description: Cartographie
description: BESM-carto_1951-49-p203_49-05
description: 203
description: 49
description: Bulletin économique et social du Maroc
description: Source: Maison méditerranéenne des sciences de l'homme, Cité numérique de la Méditerranée (Cinumed), Bibliothèque nationale du Royaume du Maroc (BNRM)
description: Source: Bulletin économique et social du Maroc
description: Source: Bulletin économique et social du Maroc (BESM) > BESM (Cartographie)
description: Relation: https://cinumed.mmsh.univ-aix.fr/idurl/1/81965
description: Coverage: Maroc
description: Coverage: Jerada
description: Coverage: XXe siècle
description: Temporal: XXe siècle
description: Bibliographic citation: « Bassin minier de Djérada (extrait de carte) [Guenfouda, El Aouinet] », In Bulletin économique et social du Maroc (BESM), n° 49, 1951
description: Provenance: Maison méditerranéenne des sciences de l'homme, Cité numérique de la Méditerranée (Cinumed), Bibliothèque nationale du Royaume du Maroc (BNRM)
description: Provenance: https://cinumed.mmsh.univ-aix.fr/
Setaphyes dentatus
Creators: name: Neuhaus, Birger
name: Lu, Borong
name: Yamasaki, Hiroshi
name: González-Casarrubios, Alberto
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Kinorhyncha
Allomalorhagida
Pycnophyidae
Setaphyes
Setaphyes dentatus

description: Infestation of Setaphyes dentatus
No ciliate epibionts or filamentous bacteria were noticed on the specimens collected 1988 and 1998. Altogether, 27 specimens of Trematosoma husselae sp. nov. were noted on three out of 13 specimens of S. dentatus collected in June 2016. One kinorhynch hosted 2, 3, or 22 epibionts (Table 5). One specimen also revealed filamentous prokaryotic epibionts (Table 5). No specimens of C. buetschlii were traced on any of the 14 specimens of S. dentatus collected 2016.
ex
description: Published as part of Neuhaus, Birger, Lu, Borong, Yamasaki, Hiroshi & González-Casarrubios, Alberto, 2023, Epibiontic life on intertidal Setaphyes kielensis and S. dentatus (Kinorhyncha, Pycnophyidae) from Sylt, North Sea, Germany, with a description of a new species of Trematosoma (Ciliophora, Acinetidae) and a redescription of Cothurnia buetschlii (Ciliophora, Vaginicolidae), pp. 439-470 in Zootaxa 5343 (5) on page 460, DOI: 10.11646/zootaxa.5343.5.2, http://zenodo.org/record/8345479