cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
ABO phenotype-protected reproduction based on human specific α1,2 L-fucosylation as explained by the Bombay type formation
Creators: name: Arend, Peter
Publisher: name: figshare
Year: 2017
Subjects: subject: Hematology
subject: Medicine
subject: Biochemistry
subject: Cancer
subject: Biological Techniques
subject: Immunology
subject: FOS: Clinical medicine
subject: Computational Chemistry
subject: Molecular Biology
subject: Stem Cells
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Anatomy

description: The metabolic relationships between the formation of the ABO(H) blood group phenotype and human fertility are evident in the rare (Oh) or Bombay blood type, which Charles Darwin would have interpreted as resulting from reduced male fertility in consanguinities, based on the history of his own family, the Darwin/Wedgewood Dynasty. The classic Bombay type occurs with the extremely rare and human specific genotype (h/h; se/se), which (due to point mutations) does not encode the fucosyltransferases 1(FUT1) and FUT2, representing the functional basis for ABO(H) phenotype formation on the cell surfaces, secretions and plasma proteins. In non-O(H) blood groups, phenotypic glycosylation regulates the physiological anti-self reactivity of the non-immune IgM molecule. While the plasma of the normal blood group O(H) is associated with a mixture of adaptive and non-immune anti-A/Tn and anti-B-reactive isoagglutinins, the levels of these agglutinins are strongly increased in the non- or poorly fucosylated O(h), Bombay type plasma, which additionally exhibits a complex, unusual anti-H reactivity and pronounced non-immune anti-A/Tn cross-reactivity. This cross-reactivity normally arises from the non-somatic, blood-group-independent (A-like), developmental GalNAcα1-O-Ser/Thr glycosylations, characterizing the embryonic stem fidelity in germ cell transformation, which in the case of poor plasma fucosylation assumingly involves an unphysiological suppression by the elevated anti-A/Tn levels, and formation of aberrant, immunologically incompatible glycans.
Bayesian Ising Graphical Model for Variable Selection
Creators: name: Zaili Fang
name: Inyoung Kim
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: In this article, we propose a new Bayesian variable selection (BVS) approach via the graphical model and the Ising model, which we refer to as the “Bayesian Ising graphical model” (BIGM). The BIGM is developed by showing that the BVS problem based on the linear regression model can be considered as a complete graph and described by an Ising model with random interactions. There are several advantages of our BIGM: it is easy to (i) employ the single-site updating and cluster updating algorithm, both of which are suitable for problems with small sample sizes and a larger number of variables, (ii) extend this approach to nonparametric regression models, and (iii) incorporate graphical prior information. In our BIGM, the interactions are determined by the linear model coefficients, so we systematically study the performance of different scale normal mixture priors for the model coefficients by adopting the global-local shrinkage strategy. Our results indicate that the best prior for the model coefficients in terms of variable selection should place substantial weight on small, nonzero shrinkage. The methods are illustrated with simulated and real data. Supplementary materials for this article are available online.
title: Vom Seelengefährt zum Glorienleib
title: Formen aitherischer Leiblichkeit (kompletter Band)
titleType: Subtitle
Creators: name: (:Unkn) Unknown
Publisher: name: Freie Universität Berlin
Year: 2018
Subjects: subject: ochema
subject: Seelenvehikel
subject: Seelenwagen
subject: Feinstofflichkeit
subject: Mittelstellung der Seele
subject: 100 Philosophie und Psychologie::180 Antike, mittelalterliche und östliche Philosophie::184 Platonische Philosophie

description: Das Konzept des Seelengefährts, das bereits von Platon und zuvor von Parmenides konzipiert wurde, ist für die philosophische Selbstverständigung von der Antike bis in die frühe Au lärung und darüber hinaus die moderne Esoterik von zentraler Bedeutung. Sein veranschaulichendes Potenzial reicht von der Erkundung der Möglichkeiten der Kommunikation zwischen eigentlich klar voneinander geschiedenen ontologischen Räumen – dem des Unsto ich-Göttlichen einerseits und dem des Sto ich-Irdischen bzw. menschlich Seelischen andererseits – bis hin zu natur philosophischen Entwürfen zur Erklärung des Phänomens der Elektrizität. Immer wieder wurde es von so unterschiedlichen Denkern wie z. B. Plutarch, Bernardus Silvestris, Kepler, Suarez oder Christian Wolf herangezogen, um das Problem der Einwirkung des Intelligiblen und Göttlichen auf die menschliche Seele oder die irdische Natur zu erklären. Es motivierte Dichter wie Traherne oder Donne zu literarischen Inszenierungen sympathetisch-aitherischer Leiblichkeit und deren eschatologischen Implikationen. Diesem zentralen und spannungsvollen Themenspektrum in seiner historischen wie thematischen Kontinuität nähern sich die Autor*innen dieses Bandes aus interdisziplinär verschränkter Perspektive, die zudem eine innovative, künstlerische Auseinandersetzung mit den verschiedenen Aspekten des Licht(-leib)es umfasst.
Bibliografie der nachgelassenen Privatbibliothek von Ernst Ludwig Ehrlich
Creators: name: (:Unkn) Unknown
Publisher: name: Freie Universität Berlin
Year: 2011
Subjects: subject: 000 Informatik, Informationswissenschaft, allgemeine Werke::010 Bibliografien::012 Bibliografien von Einzelpersonen
subject: 200 Religion::290 Andere Religionen::296 Judentum
subject: 200 Religion::230 Christentum, christliche Theologie
subject: 900 Geschichte und Geografie::940 Geschichte Europas::943 Geschichte Mitteleuropas; Deutschlands

description: Vorwort Bibliografie Register Editorische Notiz
description: Die Bibliografie umfasst rund 8.000 Titel, die sich ehemals im Besitz von Ernst Ludwig Ehrlich, einem bedeutenden Forscher im christlich-jüdischen Dialog, befanden und dem Seminar für Katholische Theologie geschenkt wurden.
Megalonema Eigenmann 1912
Creators: name: Lundberg, John G.
name: Dahdul, Wasila M.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Siluriformes
Pimelodidae
Megalonema

description: Megalonema Eigenmann, 1912 Megalonema Eigenmann, 1912a: 150. Gender neuter. Type species. Megalonema platycephalum Eigenmann, 1912a, by original designation. Diagnosis. Eigenmann’s (1912a) diagnosis of Megalonema is a mixture of derived and plesiomorphic character states, each with a checkered distribution among pimelodids. Accordingly, we offer an alternative diagnosis emphasizing unique or unambiguous synapomorphies. Thus, Megalonema is characterized by the following. A unique structure of the gas bladder and its encapsulating processes of the Weberian complex (Fig. 1) including: reduced, dumbbell-shaped gas bladder with distended lateral lobes connected by a tubular commissure ventrally crossing Weberian compound centrum; paired, ventrally incomplete bony capsules surrounding lateral lobes of gas bladder formed by deeply down-curved 4 th transverse processes of Weberian complex; a prominent ventral flange of compound centrum immediately anterior to tubular commissure of gas bladder and sutural joint with 5 th centrum. Paired bony canals of passage for posterior cardinal veins and median aortic canal all very short, formed by ventral flange crossing compound centrum. Bony aortic canal, in some specimens, continued anterior to ventral flange by a second thin midventral bridge (Fig. 1). Transformator process of tripus reduced to a thin tapering splint on anteromedial wall of gas bladder lobe. Vertebral centra five and six articulate by a in Megalonema, small median sac with anterior projections in the Calophysus group, and a pair of small separate sacs in Hypophthalmus. We also note that Megalonema may have a possibly diagnostic dark caudal spot embedded within the base of upper lobe of the caudal fin, internal to uppermost 4-5 branched fin rays. Some specimens show a matching spot on the lower lobe. We have observed the upper caudal spot in specimens of all species except M. argentina (no specimens examined) and M. xanthum for which the only available specimens are the faded types collected nearly a century ago. It is possible that M. xanthum has the caudal spot in life but it is bleached out as it is in faded specimens of other species. Upper lobe caudal spots in a similar position are also found in Pimelodidae in Hemisorubim, Platysilurus and Platystomatichthys, but in these the pigmentation is chromatophores in the skin, external to the fin rays.
description: Published as part of Lundberg, John G. & Dahdul, Wasila M., 2008, Two new cis-Andean species of the South American catfish genus Megalonema allied to trans-Andean Megalonema xanthum, with description of a new subgenus (Siluriformes: Pimelodidae), pp. 439-454 in Neotropical Ichthyology 6 (3) on pages 440-441, DOI: 10.1590/S1679-62252008000300018, http://zenodo.org/record/5419874
Fast Hamiltonian Monte Carlo Using GPU Computing
Creators: name: Beam, Andrew L.
name: Ghosh, Sujit K.
name: Doyle, Jon
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: In recent years, the Hamiltonian Monte Carlo (HMC) algorithm has been found to work more efficiently compared to other popular Markov chain Monte Carlo (MCMC) methods (such as random walk Metropolis–Hastings) in generating samples from a high-dimensional probability distribution. HMC has proven more efficient in terms of mixing rates and effective sample size than previous MCMC techniques, but still may not be sufficiently fast for particularly large problems. The use of GPUs promises to push HMC even further greatly increasing the utility of the algorithm. By expressing the computationally intensive portions of HMC (the evaluations of the probability kernel and its gradient) in terms of linear or element-wise operations, HMC can be made highly amenable to the use of graphics processing units (GPUs). A multinomial regression example demonstrates the promise of GPU-based HMC sampling. Using GPU-based memory objects to perform the entire HMC simulation, most of the latency penalties associated with transferring data from main to GPU memory can be avoided. Thus, the proposed computational framework may appear conceptually very simple, but has the potential to be applied to a wide class of hierarchical models relying on HMC sampling. Models whose posterior density and corresponding gradients can be reduced to linear or element-wise operations are amenable to significant speed ups through the use of GPUs. Analyses of datasets that were previously intractable for fully Bayesian approaches due to the prohibitively high computational cost are now feasible using the proposed framework.
A grammar of Moloko
Creators: name: Friesen, Dianne
Publisher: name: Freie Universität Berlin
Year: 2017
Subjects: subject: 400 Sprache::410 Linguistik

description: This grammar provides the first comprehensive grammatical description of Moloko, a Chadic language spoken by about 10,000 speakers in northern Cameroon. The grammar was developed from hours and years that the authors spent at friends’ houses hearing and recording stories, hours spent listening to the tapes and transcribing the stories, then translating them and studying the language through them. Time was spent together and with others speaking the language and talking about it, translating resources and talking to Moloko people about them. Grammar and phonology discoveries were made in the office, in the fields while working, and at gatherings. In the process, the four authors have become more and more passionate about the Moloko language and are eager to share their knowledge about it with others. Intriguing phonological aspects of Moloko include the fact that words have a consonantal skeleton and only one underlying vowel (but with ten phonetic variants). The simplicity of the vowel system contrasts with the complexity of the verb word, which can include information (in addition to the verbal idea) about subject, direct object (semantic Theme), indirect object (recipient or beneficiary), direction, location, aspect (Imperfective and Perfective), mood (indicative, irrealis, iterative), and Perfect aspect. Some of the fascinating aspects about the grammar of Moloko include transitivity issues, question formation, presupposition, and the absence of simple adjectives as a grammatical class. Most verbs are not inherently transitive or intransitive, but rather the semantics is tied to the number and type of core grammatical relations in a clause. Morphologically, two types of verb pronominals indicate two kinds of direct object; both are found in ditransitive clauses. Noun incorporation of special ‘body-part’ nouns in some verbs adds another grammatical argument and changes the lexical characteristics of the verb. Clauses of zero transitivity can occur in main clauses due to the use of dependent verb forms and ideophones. Question formation is interesting in that the interrogative pronoun is clause-final for most constructions. The clause will sometimes be reconfigured so that the interrogative pronoun can be clause-final. Expectation is a foundational pillar for Moloko grammar. Three types of irrealis mood relate to speaker’s expectation concerning the accomplishment of an event. Clauses are organised around the concept of presupposition, through the use of the na-construction. Known or expected elements are marked with the na particle. There are no simple adjectives in Moloko; all adjectives are derived from nouns. The authors invite others to further explore the intricacies of the phonology and grammar of this intriguing language.
MPEC 2024-E102 : COMET C/2024 E1 (Wierzchos)
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: COMET C/2024 E1 (Wierzchos)

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Knipowitschia longecaudata
Creators: name: Sayyadzadeh, Golnaz
name: Esmaeili, Hamid Reza
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Perciformes
Gobiidae
Knipowitschia
Knipowitschia longecaudata

description: 255. Knipowitschia longecaudata (Kessler, 1877)
Common name. Long-tailed dwarf goby
Taxonomy. Original description: Gobius longecaudatus Kessler, 1877: 35, pl. 3 (fig. 8) [Southern and middle Caspian Sea; syntypes: BMNH 1897.7.5.10 [ex ZIN, var. C] (1), ZIN (lost)].
Revisions. None.
Illustrations. Zarei et al. (2022a: 173, fig. 19).
Distribution in Iran. —Distribution in River Basin: Caspian Sea.―Distribution in Ecoregions: 452-Caspian Marine.
Status in Iran. [Native].—Gavmahi-e dom deraz.—Listed in previous checklists from Iran by Esmaeili et al. (2017 a, 2018) and Jouladeh-Roudbar et al. (2020).—Iran material: ZM-CBSU.
Conservation. —IUCN: LC.
description: Published as part of Sayyadzadeh, Golnaz & Esmaeili, Hamid Reza, 2024, Freshwater lamprey and fishes of Iran: Reappraisal and updated checklist with a note on Eagderi et al. (2022), pp. 1-99 in Zootaxa 5402 (1) on page 79, DOI: 10.11646/zootaxa.5402.1.1, http://zenodo.org/record/10524097
Fast Hamiltonian Monte Carlo Using GPU Computing
Creators: name: Beam, Andrew L.
name: Ghosh, Sujit K.
name: Doyle, Jon
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Chemistry

description: In recent years, the Hamiltonian Monte Carlo (HMC) algorithm has been found to work more efficiently compared to other popular Markov Chain Monte Carlo (MCMC) methods (such as random walk Metropolis-Hastings) in generating samples from a high-dimensional probability distribution. HMC has proven more efficient in terms of mixing rates and effective sample size than previous MCMC techniques, but still may not be sufficiently fast for particularly large problems. The use of GPUs promises to push HMC even further greatly increasing the utility of the algorithm. By expressing the computationally intensive portions of HMC (the evaluations of the probability kernel and its gradient) in terms of linear or element-wise operations HMC can be made highly amenable to the use of graphics processing units (GPUs). A multinomial regression example demonstrates the promise of GPU-based HMC sampling. Using GPU-based memory objects to perform the entire HMC simulation, most of the latency penalties associated with transferring data from main to GPU memory can be avoided. Thus, the proposed computational framework may appear conceptually very simple, but has the potential to be applied to a wide class of hierarchical models relying on HMC sampling. Models whose posterior density and corresponding gradients can be reduced to linear or element-wise operations are amenable to significant speed ups through the use of GPUs. Analyses of data sets that were previously intractable for fully Bayesian approaches due to the prohibitively high computational cost are now feasible using the proposed framework.
QQ Models: Joint Modeling for Quantitative and Qualitative Quality Responses in Manufacturing Systems
Creators: name: Xinwei Deng
name: Jin, Ran
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Information and Computing Sciences
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Earth and Environmental Sciences
subject: Genetics
subject: FOS: Biological sciences

description: A manufacturing system with both quantitative and qualitative (QQ) quality responses (as a QQ system) is widely encountered in many cases. For example, in a lapping process of the semiconductor manufacturing, the quality of wafer's geometrical characteristics is often measured by the total thickness variation as a quantitative response and the conformity of site total indicator reading as a binary qualitative response. The QQ responses are closely associated with each other in a QQ system, but current methodologies often model the two types of quality responses separately. This paper presents a novel modeling approach, called “QQ models”, to jointly model the QQ responses through a constrained likelihood estimation. The QQ models can jointly select significant predictors by incorporating inherent features of QQ systems, leading to accurate variable selection and prediction. Both simulation studies and a case study in a lapping process are used to evaluate the performance of the proposed method.
QQ Models: Joint Modeling for Quantitative and Qualitative Quality Responses in Manufacturing Systems
Creators: name: Xinwei Deng
name: Jin, Ran
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Information and Computing Sciences
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Earth and Environmental Sciences
subject: Genetics
subject: FOS: Biological sciences

description: A manufacturing system with both quantitative and qualitative (QQ) quality responses (as a QQ system) is widely encountered in many cases. For example, in a lapping process of the semiconductor manufacturing, the quality of wafer’s geometrical characteristics is often measured by the total thickness variation as a quantitative response and the conformity of site total indicator reading as a binary qualitative response. The QQ responses are closely associated with each other in a QQ system, but current methodologies often model the two types of quality responses separately. This article presents a novel modeling approach, called “QQ models,” to jointly model the QQ responses through a constrained likelihood estimation. The QQ models can jointly select significant predictors by incorporating inherent features of QQ systems, leading to accurate variable selection and prediction. Both simulation studies and a case study in a lapping process are used to evaluate the performance of the proposed method. Supplementary materials to this article are available online.
QQ Models: Joint Modeling for Quantitative and Qualitative Quality Responses in Manufacturing Systems
Creators: name: Xinwei Deng
name: Jin, Ran
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: A manufacturing system with both quantitative and qualitative (QQ) quality responses (as a QQ system) is widely encountered in many cases. For example, in a lapping process of the semiconductor manufacturing, the quality of wafer’s geometrical characteristics is often measured by the total thickness variation as a quantitative response and the conformity of site total indicator reading as a binary qualitative response. The QQ responses are closely associated with each other in a QQ system, but current methodologies often model the two types of quality responses separately. This article presents a novel modeling approach, called “QQ models,” to jointly model the QQ responses through a constrained likelihood estimation. The QQ models can jointly select significant predictors by incorporating inherent features of QQ systems, leading to accurate variable selection and prediction. Both simulation studies and a case study in a lapping process are used to evaluate the performance of the proposed method. Supplementary materials to this article are available online.
Activation of PPARγ2 by PPARγ1 through a Functional PPRE in Transdifferentiation of Myoblasts to Adipocytes Induced by EPA
Creators: name: Hefeng Luo
name: Yuanfei Zhou
name: Xiaoming Hu
name: Xuewu Peng
name: Hongkui Wei
name: Peng, Jian
name: Siwen Jiang
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Computational Biology
subject: 60506 Virology
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Biological Sciences
subject: Meta Science
subject: Chemistry
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Biochemistry

description: PPARγ and Wnt signaling are central positive and negative regulators of adipogenesis, respectively. Here we identified that, eicosapentaenoic acid (EPA) could effectively induce the transdifferentiation of myoblasts into adipocytes through modulation of both PPARγ expression and Wnt signaling. During the early stage of transdifferentiation, EPA activates PPARδ and PPARγ1, which in turn targets β-catenin to degradation and down-regulates Wnt/β-catenin signaling, such that the myogenic fate of myoblasts could be switched to adipogenesis. In addition, EPA up-regulates the expression of PPARγ1 by activating RXRα, then PPARγ1 binds to the functional peroxisome proliferator responsive element (PPRE) in the promoter of adipocyte-specific PPARγ2 to continuously activate the expression of PPARγ2 throughout the transdifferentiation process. Our data indicated that EPA acts as a dual-function stimulator of adipogenesis that both inhibits Wnt signaling and induces PPARγ2 expression to facilitate the transdifferentiation program, and the transcriptional activation of PPARγ2 by PPARγ1 is not only the key factor for the transdifferentiation of myoblasts to adipocytes, but also the crucial evidence for successful transdifferentiation. The present findings provided insight for the first time as to how EPA induces the transdifferentiation of myoblasts to adipocytes, but also provide new clues for strategies to prevent and treat some metabolic diseases.
title: Πρόταση αποκατάστασης - επανάχρησης Αρχοντικού "Τριγύρη" στον οικισμό Βούτες Ηρακλείου
title: Restoration - reuse of Trigiris mansion in Voutes settlement  of Herakion
Creators: name: Κουλογεωργιου Μαρια
Publisher: name: Technical University of Crete
Year: 2024

description: Η παρούσα διπλωματική εργασία έχει ως αντικείμενο την αποκατάσταση και
επανάχρηση του αρχοντικού «Τριγύρη». Πρόκειται για νεοκλασικό κτίριο του
ύστερου νεοκλασικισμού, αρχή του 20ου αιώνα το οποίο βρίσκεται στον οικισμό
Βούτες του δήμου Ηρακλείου, το οποίο κυρήχθηκε διατηρητέο το 1985 (ΦΕΚ 183/4-
04-1985). Πρόκειται για τριώροφο κτίριο κτισμένο γύρω στο 1922 στον οικισμό
Βουτών Ηρακλείου, μεγάλης αρχιτεκτονικής αλλά και ιστορικής αξίας μιας και
αποτελεί χαρακτηριστικό δείγμα νεοκλασικής αρχιτεκτονικής. Το κτίριο επιτάσσεται
κατά τη γερμανική κατοχή και μετατρέπεται από τους Γερμανούς σε διοικητήριο.
Αργότερα κατοικήθηκε από την οικογένεια Τριγύρη μέχρι περίπου το 2004 όπου και
εγκαταλείφθηκε.
Σκοπός της εργασίας είναι η αποκατάσταση του κτιρίου, η ανάδειξη και
επανάχρηση του, σύμφωνα με τις σύγχρονες τάσεις και τους διεθνείς χάρτες για την
προστασία και αποκατάσταση των μνημείων. Για τον σκοπό αυτόν,
πραγματοποιήθηκε ιστορική και αρχιτεκτονική τεκμηρίωση του μνημείου,
αξιολογήθηκε η υφιστάμενη κατάσταση της παθολογίας του, εκτιμήθηκαν οι αξίες
που φέρει και προσδιορίστηκαν οι προτεινόμενες επεμβάσεις. Μεθοδολογικά η
έρευνα βασίστηκε σε βιβλιογραφικό υλικό, επιτόπια έρευνα, καταγραφή των
αρχιτεκτονικών και κατασκευαστικών στοιχείων του ακινήτου και έγινε αποτύπωση
του κτιρίου. Αρχιτεκτονικά σχέδια και γενικότερα στοιχεία για το κτίριο δε βρέθηκαν
στις δημόσιες υπηρεσίες του Ηρακλείου.
Ruthenium dinitrosyl complexes – computational characterization of structure and reactivity
Creators: name: Attia, Amr A.A.
name: Dereven’kov, Ilia A.
name: Silaghi-Dumitrescu, Radu
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Developmental Biology
Biological Sciences
Chemistry
Cell Biology
Physics
Biochemistry
Biophysics

description: Elucidation of the electronic structure of a dinitrosyl dithiolate ruthenium complex in several formal oxidation states ranging from Ru(I) to Ru(III) has been undertaken. DFT and ab initio molecular dynamics simulations have shown clear evidence of asymmetry within the dinitrosyl moieties in all models though most noticeably in the excited states. The reaction pathway of a hyponitrite adduct formation was also examined and found to be more feasible in the excited states. These results, along with the recently reported study on the dinitrosyl dithiolate iron analog of these complexes, provide insight toward the mechanism of NO donation by dinitrosyl metal complexes.
ABO phenotype-protected reproduction based on human specific α1,2 L-fucosylation as explained by the Bombay type formation
Creators: name: Arend, Peter
Publisher: name: figshare
Year: 2017
Subjects: subject: Hematology
subject: Medicine
subject: Biochemistry
subject: Cancer
subject: Biological Techniques
subject: Immunology
subject: FOS: Clinical medicine
subject: Computational Chemistry
subject: Molecular Biology
subject: Stem Cells
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Anatomy

description: The metabolic relationships between the formation of the ABO(H) blood group phenotype and human fertility are evident in the rare (Oh) or Bombay blood type, which Charles Darwin would have interpreted as resulting from reduced male fertility in consanguinities, based on the history of his own family, the Darwin/Wedgewood Dynasty. The classic Bombay type occurs with the extremely rare and human specific genotype (h/h; se/se), which (due to point mutations) does not encode the fucosyltransferases 1(FUT1) and FUT2, representing the functional basis for ABO(H) phenotype formation on the cell surfaces, secretions and plasma proteins. In the non-O(H) blood groups A and B, phenotypic glycosylation of plasma proteins regulates the physiological anti-self reactivity of the non-immune IgM molecule, whereas the plasma of blood group O(H) contains a mixture of adaptive and non-immune anti-A/Tn and anti-B-reactive isoagglutinins. In poorly fucosylated O(h) or Bombay type plasma, the levels of these agglutinins are strongly increased, dominated by a complex, unusual anti-H reactivity and pronounced non-immune anti-A/Tn cross-reactivity. This non-immune IgM cross-reactivity arises from complementary, blood-group-independent (A-like/Tn), GalNAcα1-O-Ser/Thr glycosylations during the metazoan embryonic stem cell–to–germ cell transformation, whereas in the case of poorly human-specific plasma fucosylation has assumingly lost the complementarity and causes transformation suppression, involving the formation of aberrant, immunologically incompatible glycans.
Activation of PPARγ2 by PPARγ1 through a functional PPRE in transdifferentiation of myoblasts to adipocytes induced by EPA
Creators: name: Hefeng Luo
name: Yuanfei Zhou
name: Xiaoming Hu
name: Xuewu Peng
name: Hongkui Wei
name: Peng, Jian
name: Siwen Jiang
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Computational Biology
subject: 60506 Virology
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Biological Sciences
subject: Meta Science
subject: Chemistry
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Biochemistry

description: PPARγ and Wnt signaling are central positive and negative regulators of adipogenesis, respectively. Here we identified that, eicosapentaenoic acid (EPA) could effectively induce the transdifferentiation of myoblasts into adipocytes through modulation of both PPARγ expression and Wnt signaling. During the early stage of transdifferentiation, EPA activates PPARδ and PPARγ1, which in turn targets β-catenin to degradation and down-regulates Wnt/β-catenin signaling, such that the myogenic fate of myoblasts could be switched to adipogenesis. In addition, EPA up-regulates the expression of PPARγ1 by activating RXRα, then PPARγ1 binds to the functional peroxisome proliferator responsive element (PPRE) in the promoter of adipocyte-specific PPARγ2 to continuously activate the expression of PPARγ2 throughout the transdifferentiation process. Our data indicated that EPA acts as a dual-function stimulator of adipogenesis that both inhibits Wnt signaling and induces PPARγ2 expression to facilitate the transdifferentiation program, and the transcriptional activation of PPARγ2 by PPARγ1 is not only the key factor for the transdifferentiation of myoblasts to adipocytes, but also the crucial evidence for successful transdifferentiation. The present findings provided insight for the first time as to how EPA induces the transdifferentiation of myoblasts to adipocytes, but also provide new clues for strategies to prevent and treat some metabolic diseases.
Neoperla zonata Stark & Sivec 2008, sp. n.
Creators: name: Stark, Bill P.
name: Sivec, Ignac
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Plecoptera
Perlidae
Neoperla
Neoperla zonata

description: Neoperla zonata sp. n. (Figs. 78‐81) Material examined. Holotype ♂ from Vietnam, Lao Cai, trickle along trail from Sapa to Muong Hoa Ho River, 11 May 1995, D. Currie, J. Swann, ROM 956037 (ROM). Adult habitus. Biocellate. Head almost entirely dark brown but paired pale spots located over tentoria anterolateral to ocelli and at M‐ line; clypeus and area adjacent to lappets pale (Fig. 78). Pronotum brown with scattered, indistinct pale spots on disc. Wing membrane amber, veins brown except for costal margin. Hind femora banded with dark basal and apical bands; fore and mid femora and tibiae brown. Male. Forewing length 10 mm. Process of tergum 7 rounded and spinulose around margin. Mesal sclerite of tergum 8 flat and bearing a few sensilla basiconica. Tergum 9 with sparse lateral sensilla patches on humps and a few scattered in mesal depression (Fig. 79). Hemitergal processes long and slender. Aedeagal tube plump and poorly sclerotized except on dorsum of basal half; apex of tube trilobed; lateral lobes sparsely armed with ca. 6 large spines on sides and with a cluster of smaller spines at tips (Figs. 80‐ 81); mesal lobe unarmed. Aedeagal sac not completely everted but about equal to tube in length and armed sparsely with small spines. Female. Unknown. Larva. Unknown. Etymology. The species name refers to the banding pattern on the hind femora. Diagnosis. The aedeagus and external genitalia of this species is of the general type seen in N. taiwanica Sivec & Zwick but the lateral aedeagal lobes in that species are much smaller than those found in N. zonata (Sivec & Zwick 1987).
description: Published as part of Stark, Bill P. & Sivec, Ignac, 2008, New Species And Records Of Neoperla (Plecoptera: Perlidae) From Vietnam, pp. 19-54 in Illiesia 4 (3) on pages 42-43, DOI: 10.5281/zenodo.4758856
description: {"references": ["Sivec, I. & P. Zwick. 1987. Some Neoperla from Taiwan (Plecoptera: Perlidae). Beitrage zur Entomologie, 37: 391 - 405."]}
Homology model of human eIF2B
Creators: name: Slynko, Inna
Publisher: name: Zenodo
Year: 2020
Subjects: eIF2B, homology model

description: Homology model of human eIF2B was modeled based using cryogenic electron microscopy structure 6CAJ as a template. The modeling methodologies were used to fill the many structural gaps. If a template was available, the missing loops were modelled using structure 6EZO as our preferred human template, and 5B04 as a ‘less preferred’ yeast structure. If no suitable template was available, gaps were modelled using the de novo loop modelling tool in MOE version 2017. Very large missing loops were omitted due to the lack of knowledge about their structure. Since the structure of γ I-patch (residues 342-444) was lacking in 6CAJ but not in 6EZO, it was also modelled. The corresponding γ subunits were aligned, superimposed and I-patch was transferred to the model based on 6CAJ structure. Missing side-chains were added and other inaccuracies were fixed using the Structure Preparation tool in MOE. Hydrogen atoms were added, protonation states were assigned using Protonate3D in MOE, and the derived structure was charged using Amber10 force field. In order to remove possible clashes between side-chains, the structure was slightly minimized with restraining atoms to the initial coordinates. The final model was named “model_6CAJ”.
Ruthenium dinitrosyl complexes – computational characterization of structure and reactivity
Creators: name: Attia, Amr A.A.
name: Dereven’kov, Ilia A.
name: Silaghi-Dumitrescu, Radu
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Developmental Biology
Biological Sciences
Chemistry
Cell Biology
Physics
Biochemistry
Biophysics

description: Elucidation of the electronic structure of a dinitrosyl dithiolate ruthenium complex in several formal oxidation states ranging from Ru(I) to Ru(III) has been undertaken. DFT and ab initio molecular dynamics simulations have shown clear evidence of asymmetry within the dinitrosyl moieties in all models though most noticeably in the excited states. The reaction pathway of a hyponitrite adduct formation was also examined and found to be more feasible in the excited states. These results, along with the recently reported study on the dinitrosyl dithiolate iron analog of these complexes, provide insight towards the mechanism of NO donation by dinitrosyl metal complexes.
Activation of PPARγ2 by PPARγ1 through a functional PPRE in transdifferentiation of myoblasts to adipocytes induced by EPA
Creators: name: Hefeng Luo
name: Yuanfei Zhou
name: Xiaoming Hu
name: Xuewu Peng
name: Hongkui Wei
name: Peng, Jian
name: Siwen Jiang
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy
subject: Developmental Biology
subject: 60506 Virology
subject: Computational Biology

description: PPARγ and Wnt signaling are central positive and negative regulators of adipogenesis, respectively. Here we identified that, eicosapentaenoic acid (EPA) could effectively induce the transdifferentiation of myoblasts into adipocytes through modulation of both PPARγ expression and Wnt signaling. During the early stage of transdifferentiation, EPA activates PPARδ and PPARγ1, which in turn targets β-catenin to degradation and down-regulates Wnt/β-catenin signaling, such that the myogenic fate of myoblasts could be switched to adipogenesis. In addition, EPA up-regulates the expression of PPARγ1 by activating RXRα, then PPARγ1 binds to the functional peroxisome proliferator responsive element (PPRE) in the promoter of adipocyte-specific PPARγ2 to continuously activate the expression of PPARγ2 throughout the transdifferentiation process. Our data indicated that EPA acts as a dual-function stimulator of adipogenesis that both inhibits Wnt signaling and induces PPARγ2 expression to facilitate the transdifferentiation program, and the transcriptional activation of PPARγ2 by PPARγ1 is not only the key factor for the transdifferentiation of myoblasts to adipocytes, but also the crucial evidence for successful transdifferentiation. The present findings provided insight for the first time as to how EPA induces the transdifferentiation of myoblasts to adipocytes, but also provide new clues for strategies to prevent and treat some metabolic diseases.
Supplementary material to: Groeneweg et al. 2025. MCT8 deficiency in females. JCEM.
Creators: name: van der Most, Floor
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 320208
subject: Endocrinology

description: These are the Supplementary material to: Groeneweg et al. 2025. MCT8 deficiency in females. The Journal of Clinical Endocrinology & Metabolism.
Additional file 1 of Hi-D: nanoscale mapping of nuclear dynamics in single living cells
Creators: name: Shaban, Haitham A.
name: Barth, Roman
name: Recoules, Ludmila
name: Bystricky, Kerstin
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: Inorganic Chemistry
subject: Computational Biology

description: Contains details on the conversion from flow fields to trajectories, a detailed discussion on the distinction between confined and anomalous diffusion and a comparison of Single Particle Tracking and Optical Flow for reconstruction of motion in intermediate to high labelling density scenarios, and further discussion on the comparison of Hi-D and iMSD. It also contains Figures S1-S13.
Comparative performance of scientific and indigenous knowledge on seasonal climate forecasts: A case study of Lupane, semi- arid Zimbabwe
Creators: name: Iqbal, Zahid
name: Chagonda1*, Ignatius
name: Munodawafa1, Adelaide
name: Mugabe2, Francis T.
name: Makuvaro1, Veronica
name: Masere1, Philip
name: Murewi3, Cyril T. F.
Publisher: name: figshare
Year: 2015
Subjects: subject: Education
subject: 99901 Agricultural Engineering
subject: FOS: Other engineering and technologies
subject: Zoology
subject: FOS: Biological sciences
subject: Plant Biology

description: Seasonal climate forecasting (SCF) is weather prediction over a period ranging from 3-6 months period. Forecasting can be done using scientific forecasts (SF) or indigenous knowledge forecasts (IKF) systems. Forecast results can be very fruitful to smallholder farmers in semi-arid areas where rainfall is highly variable. Effective use of SCF has faced challenges including: rainfall variability, access to forecast information, interpretation of forecast results and generation gap. There is limited research on comparative performance of the two forecasts. The research seeks to evaluate comparative performance of the two forecasting methods in predicting outcome of the following rainfall season. The study was carried out in Daluka and Menyezwa wards of Lupane district, south-western Zimbabwe, which receives annual average rainfall of 450-650 mm. Focus group discussions and personal interviews were used in 2008/09 and 2009/10 seasons to capture farmers’ experiences and knowledge on SCFs and their application. The predicted outcome of the IKF and SF were compared with actual rainfall recorded from the predicted period. Results indicated high dependence on the use of the IKFs by Lupane farmers in predicting the outcome of the following season’s rainfall. Both the IKF and SF predicted inadequate rainfall in the two consecutive seasons and the results concurred with recorded rainfall in Daluka ward in the two seasons and in Menyezwa ward in 2009/10 season only. Results demonstrate that in the absence of SF, farmers may use IKFs. It is imperative that the two forecasts complement each other to increase farmer adaptation to climate variability.
Unawareness of bipolar disorder: the role of the cingulate cortex
Creators: name: S. Palermo
name: F. Cauda
name: T. Costa
name: S. Duca
name: G. Gallino
name: G. Geminiani
name: R. Keller
name: M. Amanzio
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Science Policy
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Neuroscience
subject: Engineering

description: Reduced awareness of illness is a well-known phenomenon that has been understudied in remitted patients with bipolar disorder. In particular, the relationship between reduced awareness and executive dysfunction is an intriguing question that has yet to be resolved. The aim of the current study is to analyze the link between reduced awareness, brain dysfunction, and concomitant cognitive-behavioral disturbances from a neurocognitive perspective. In previous studies, we demonstrated the role of the anterior cingulate cortex (ACC) in the unawareness of distinct pathologies that exhibit overlapping symptoms in the context of overlapping circuit-specific dysfunction. Given the clinical importance of the results obtained, the present study considers six aware and four unaware remitted bipolar disorder patients. Cingulate functionality was assessed with functional magnetic resonance imaging while patients performed a go/no-go task. Patients were also studied on an overall cognitive task battery and with behavioral assessment of mood changes in terms of apathy and disinhibited behavior. Unaware patients showed frontoparietal hypo-perfusion, with a significant reduction of task-sensitive activity in the bilateral superior and middle frontal gyrus, putamen, insular, and ACCs.
Purification and biochemical characterisation of acid phosphatase-I from seeds of Nelumbo nucifera
Creators: name: Sanaullah Khan
name: Khan, Shahnaz
name: Batool, Sajida
name: Ahmed, Mushtaq
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Cell Biology
subject: Microbiology
subject: FOS: Biological sciences
subject: Biochemistry

description: Acid phosphatase-I (Apase-I) from seeds of Nelumbo nucifera was purified to electrophoretic homogeneity by combination of ammonium sulfate precipitation, size-exclusion and ion exchange chromatography. SDS-PAGE of purified Apase-I gave a single band with molecular mass of 80 kDa under reducing and non-reducing conditions, indicating that the enzyme was a monomer. The purified enzyme showed maximum activity at 50°C and at pH 5. The Km, Vmax and Kcat for p-nitrophenyl phosphate were 132 μM, 10 μmol/min/mg and 6.7/sec respectively. Apase-I activity was strongly inhibited by Zn2+, W2+; weakly inhibited by Cu2+, Mo2+ and Cr6+ and moderately activated by Mg2+. The enzyme was shown to be thermolabile as it lost 50% of its activity at 50°C after incubation for 1 hour. The amino acid analysis of enzyme revealed high proportion of acidic amino acids, which is very similar to that of tomato Apase-I and lower than potato Apase.
Resources, mortality, and disease ecology: importance of positive feedbacks between host growth rate and pathogen dynamics
Creators: name: Smith, Val H.
name: Holt, Robert D.
name: Smith, Marilyn S.
name: Yafen Niu
name: Barfield, Michael
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Cancer
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Ecology
subject: Evolutionary Biology
subject: Cell Biology
subject: Microbiology

description: Resource theory and metabolic scaling theory suggest that the dynamics of a pathogen within a host should strongly depend upon the rate of host cell metabolism. Once an infection occurs, key ecological interactions occur on or within the host organism that determine whether the pathogen dies out, persists as a chronic infection, or grows to densities that lead to host death. We hypothesize that, in general, conditions favoring rapid host growth rates should amplify the replication and proliferation of both fungal and viral pathogens. If a host population experiences an increase in mortality, to persist it must have a higher growth rate, per host, often reflecting greater resource availability per capita. We hypothesize that this could indirectly foster the pathogen, which also benefits from increased within-host resource turnover. We first bring together in a short review a number of key prior studies which illustrate resource effects on viral and fungal pathogen dynamics. We then report new results from a semi-continuous cell culture experiment with SHIV, demonstrating that higher mortality rates indeed can promote viral proliferation. We develop a simple model that illustrates dynamical consequences of these resource effects, including interesting effects such as alternative stable states and oscillatory dynamics. Our paper contributes to a growing body of literature at the interface of ecology and infectious disease epidemiology, emphasizing that host abundances alone do not drive community dynamics: the physiological state and resource content of infected hosts also strongly influence host–pathogen interactions.