Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
Creators: name: Meyerson, William U.
name: Dursi, Lewis Jonathan
name: Wang, Liang-Bo
name: Dong, Guanlan
name: Liang, Wen-Wei
name: Weerasinghe, Amila
name: Li, Yize
name: Kelso, Sean
name: Wendl, Michael C.
name: Simpson, Jared T.
name: Akbani, Rehan
name: Anur, Pavana
name: Bailey, Matthew H.
name: Buchanan, Alex
name: Chiotti, Kami
name: Covington, Kyle
name: Creason, Allison
name: Ding, Li
name: Ellrott, Kyle
name: Fan, Yu
name: Foltz, Steven
name: Getz, Gad
name: Hale, Walker
name: Haussler, David
name: Hess, Julian M.
name: Hutter, Carolyn M.
name: Kandoth, Cyriac
name: Kasaian, Katayoon
name: Kasapi, Melpomeni
name: Larson, Dave
name: Leshchiner, Ignaty
name: Letaw, John
name: Ma, Singer
name: McLellan, Michael D.
name: Men, Yifei
name: Mills, Gordon B.
name: Niu, Beifang
name: Peto, Myron
name: Radenbaugh, Amie
name: Reynolds, Sheila M.
name: Saksena, Gordon
name: Sofia, Heidi
name: Stewart, Chip
name: Struck, Adam J.
name: Stuart, Joshua M.
name: Wang, Wenyi
name: Weinstein, John N.
name: Wheeler, David A.
name: Wong, Christopher K.
name: Xi, Liu
name: Ye, Kai
name: Bieg, Matthias
name: Boutros, Paul C.
name: Buchhalter, Ivo
name: Butler, Adam P.
name: Chen, Ken
name: Chong, Zechen
name: Drechsel, Oliver
name: Jonathan Dursi, Lewis
name: Eils, Roland
name: Espiritu, Shadrielle M. G.
name: Fulton, Robert S.
name: Gao, Shengjie
name: Gelpi, Josep L. L.
name: Gerstein, Mark B.
name: Gonzalez, Santiago
name: Gut, Ivo G.
name: Hach, Faraz
name: Heinold, Michael C.
name: Hinton, Jonathan
name: Hu, Taobo
name: Huang, Vincent
name: Huang, Yi
name: Hutter, Barbara
name: Jones, David R.
name: Jung, Jongsun
name: Jäger, Natalie
name: Kim, Hyung-Lae
name: Kleinheinz, Kortine
name: Kumar, Sushant
name: Kumar, Yogesh
name: Lalansingh, Christopher M.
name: Letunic, Ivica
name: Livitz, Dimitri
name: Ma, Eric Z.
name: Maruvka, Yosef E.
name: Mashl, R. Jay
name: Menzies, Andrew
name: Milovanovic, Ana
name: Nielsen, Morten Muhlig
name: Ossowski, Stephan
name: Paramasivam, Nagarajan
name: Pedersen, Jakob Skou
name: Perry, Marc D.
name: Puiggròs, Montserrat
name: Raine, Keiran M.
name: Rheinbay, Esther
name: Royo, Romina
name: Sahinalp, S. Cenk
name: Sarrafi, Iman
name: Schlesner, Matthias
name: Stebbings, Lucy
name: Stobbe, Miranda D.
name: Teague, Jon W.
name: Tiao, Grace
name: Torrents, David
name: Wala, Jeremiah A.
name: Wang, Jiayin
name: Waszak, Sebastian M.
name: Weischenfeldt, Joachim
name: Werner, Johannes
name: Wu, Zhenggang
name: Xue, Hong
name: Yakneen, Sergei
name: Yamaguchi, Takafumi N.
name: Yellapantula, Venkata D.
name: Yung, Christina K.
name: Zhang, Junjun
name: Aaltonen, Lauri A.
name: Abascal, Federico
name: Abeshouse, Adam
name: Aburatani, Hiroyuki
name: Adams, David J.
name: Agrawal, Nishant
name: Ahn, Keun Soo
name: Ahn, Sung-Min
name: Aikata, Hiroshi
name: Akdemir, Kadir C.
name: Al-Ahmadie, Hikmat
name: Al-Sedairy, Sultan T.
name: Al-Shahrour, Fatima
name: Alawi, Malik
name: Albert, Monique
name: Aldape, Kenneth
name: Alexandrov, Ludmil B.
name: Ally, Adrian
name: Alsop, Kathryn
name: Alvarez, Eva G.
name: Amary, Fernanda
name: Amin, Samirkumar B.
name: Aminou, Brice
name: Ammerpohl, Ole
name: Anderson, Matthew J.
name: Ang, Yeng
name: Antonello, Davide
name: Aparicio, Samuel
name: Appelbaum, Elizabeth L.
name: Arai, Yasuhito
name: Aretz, Axel
name: Arihiro, Koji
name: Ariizumi, Shun-Ichi
name: Armenia, Joshua
name: Arnould, Laurent
name: Asa, Sylvia
name: Assenov, Yassen
name: Atwal, Gurnit
name: Aukema, Sietse
name: Auman, J. Todd
name: Aure, Miriam R.
name: Awadalla, Philip
name: Aymerich, Marta
name: Bader, Gary D.
name: Baez-Ortega, Adrian
name: Bailey, Peter J.
name: Balasundaram, Miruna
name: Balu, Saianand
name: Bandopadhayay, Pratiti
name: Banks, Rosamonde E.
name: Barbi, Stefano
name: Barbour, Andrew P.
name: Barenboim, Jonathan
name: Barnholtz-Sloan, Jill
name: Barr, Hugh
name: Barrera, Elisabet
name: Bartlett, John
name: Bartolome, Javier
name: Bassi, Claudio
name: Bathe, Oliver F.
name: Baumhoer, Daniel
name: Bavi, Prashant
name: Baylin, Stephen B.
name: Bazant, Wojciech
name: Beardsmore, Duncan
name: Beck, Timothy A.
name: Behjati, Sam
name: Behren, Andreas
name: Bell, Cindy
name: Beltran, Sergi
name: Benz, Christopher
name: Berchuck, Andrew
name: Bergmann, Anke K.
name: Bergstrom, Erik N.
name: Berman, Benjamin P.
name: Berney, Daniel M.
name: Bernhart, Stephan H.
name: Beroukhim, Rameen
name: Berrios, Mario
name: Bersani, Samantha
name: Bertl, Johanna
name: Betancourt, Miguel
name: Bhandari, Vinayak
name: Bhosle, Shriram G.
name: Biankin, Andrew V.
name: Bigner, Darell
name: Binder, Hans
name: Birney, Ewan
name: Birrer, Michael
name: Biswas, Nidhan K.
name: Bjerkehagen, Bodil
name: Bodenheimer, Tom
name: Boice, Lori
name: Bonizzato, Giada
name: De Bono, Johann S.
name: Boot, Arnoud
name: Bootwalla, Moiz S.
name: Borg, Ake
name: Borkhardt, Arndt
name: Boroevich, Keith A.
name: Borozan, Ivan
name: Borst, Christoph
name: Bosenberg, Marcus
name: Bosio, Mattia
name: Boultwood, Jacqueline
name: Bourque, Guillaume
name: Bova, G. Steven
name: Bowen, David T.
name: Bowlby, Reanne
name: Bowtell, David D. L.
name: Boyault, Sandrine
name: Boyce, Rich
name: Boyd, Jeffrey
name: Brazma, Alvis
name: Brennan, Paul
name: Brewer, Daniel S.
name: Brinkman, Arie B.
name: Bristow, Robert G.
name: Broaddus, Russell R.
name: Brock, Jane E.
name: Brock, Malcolm
name: Broeks, Annegien
name: Brooks, Angela N.
name: Brooks, Denise
name: Brors, Benedikt
name: Brunak, Søren
name: Bruxner, Timothy J. C.
name: Bruzos, Alicia L.
name: Buchholz, Christiane
name: Bullman, Susan
name: Burke, Hazel
name: Burkhardt, Birgit
name: Burns, Kathleen H.
name: Busanovich, John
name: Bustamante, Carlos D.
name: Butte, Atul J.
name: Byrne, Niall J.
name: Børresen-Dale, Anne-Lise
name: Caesar-Johnson, Samantha J.
name: Cafferkey, Andy
name: Cahill, Declan
name: Calabrese, Claudia
name: Caldas, Carlos
name: Calvo, Fabien
name: Camacho, Niedzica
name: Campbell, Peter J.
name: Campo, Elias
name: Cantù, Cinzia
name: Cao, Shaolong
name: Carey, Thomas E.
name: Carlevaro-Fita, Joana
name: Carlsen, Rebecca
name: Cataldo, Ivana
name: Cazzola, Mario
name: Cebon, Jonathan
name: Cerfolio, Robert
name: Chadwick, Dianne E.
name: Chakravarty, Dimple
name: Chalmers, Don
name: Chan, Calvin Wing Yiu
name: Chan, Kin
name: Chan-Seng-Yue, Michelle
name: Chandan, Vishal S.
name: Chang, David K.
name: Chanock, Stephen J.
name: Chantrill, Lorraine A.
name: Chateigner, Aurélien
name: Chatterjee, Nilanjan
name: Chayama, Kazuaki
name: Chen, Hsiao-Wei
name: Chen, Jieming
name: Chen, Yiwen
name: Chen, Zhaohong
name: Cherniack, Andrew D.
name: Chien, Jeremy
name: Chiew, Yoke-Eng
name: Chin, Suet-Feung
name: Cho, Juok
name: Cho, Sunghoon
name: Choi, Jung Kyoon
name: Choi, Wan
name: Chomienne, Christine
name: Choo, Su Pin
name: Chou, Angela
name: Christ, Angelika N.
name: Christie, Elizabeth L.
name: Chuah, Eric
name: Cibulskis, Carrie
name: Cibulskis, Kristian
name: Cingarlini, Sara
name: Clapham, Peter
name: Claviez, Alexander
name: Cleary, Sean
name: Cloonan, Nicole
name: Cmero, Marek
name: Collins, Colin C.
name: Connor, Ashton A.
name: Cooke, Susanna L.
name: Cooper, Colin S.
name: Cope, Leslie
name: Corbo, Vincenzo
name: Cordes, Matthew G.
name: Cordner, Stephen M.
name: Cortés-Ciriano, Isidro
name: Cowin, Prue A.
name: Craft, Brian
name: Craft, David
name: Creighton, Chad J.
name: Cun, Yupeng
name: Curley, Erin
name: Cutcutache, Ioana
name: Czajka, Karolina
name: Czerniak, Bogdan
name: Dagg, Rebecca A.
name: Danilova, Ludmila
name: Davi, Maria Vittoria
name: Davidson, Natalie R.
name: Davies, Helen
name: Davis, Ian J.
name: Davis-Dusenbery, Brandi N.
name: Dawson, Kevin J.
name: De La Vega, Francisco M.
name: De Paoli-Iseppi, Ricardo
name: Defreitas, Timothy
name: Dei Tos, Angelo P.
name: Delaneau, Olivier
name: Demchok, John A.
name: Demeulemeester, Jonas
name: Demidov, German M.
name: Demircioğlu, Deniz
name: Dennis, Nening M.
name: Denroche, Robert E.
name: Dentro, Stefan C.
name: Desai, Nikita
name: Deshpande, Vikram
name: Deshwar, Amit G.
name: Desmedt, Christine
name: Deu-Pons, Jordi
name: Dhalla, Noreen
name: Dhani, Neesha C.
name: Dhingra, Priyanka
name: Dhir, Rajiv
name: DiBiase, Anthony
name: Diamanti, Klev
name: Ding, Shuai
name: Dinh, Huy Q.
name: Dirix, Luc
name: Doddapaneni, HarshaVardhan
name: Donmez, Nilgun
name: Dow, Michelle T.
name: Drapkin, Ronny
name: Drews, Ruben M.
name: Serge, Serge
name: Dudderidge, Tim
name: Dueso-Barroso, Ana
name: Dunford, Andrew J.
name: Dunn, Michael
name: Duthie, Fraser R.
name: Dutton-Regester, Ken
name: Eagles, Jenna
name: Easton, Douglas F.
name: Edmonds, Stuart
name: Edwards, Paul A.
name: Edwards, Sandra E.
name: Eeles, Rosalind A.
name: Ehinger, Anna
name: Eils, Juergen
name: El-Naggar, Adel
name: Eldridge, Matthew
name: Erkek, Serap
name: Escaramis, Georgia
name: Estivill, Xavier
name: Etemadmoghadam, Dariush
name: Eyfjord, Jorunn E.
name: Faltas, Bishoy M.
name: Fan, Daiming
name: Faquin, William C.
name: Farcas, Claudiu
name: Fassan, Matteo
name: Fatima, Aquila
name: Favero, Francesco
name: Fayzullaev, Nodirjon
name: Felau, Ina
name: Fereday, Sian
name: Ferguson, Martin L.
name: Ferretti, Vincent
name: Feuerbach, Lars
name: Field, Matthew A.
name: Fink, J. Lynn
name: Finocchiaro, Gaetano
name: Fisher, Cyril
name: Fittall, Matthew W.
name: Fitzgerald, Anna
name: Fitzgerald, Rebecca C.
name: Flanagan, Adrienne M.
name: Fleshner, Neil E.
name: Flicek, Paul
name: Foekens, John A.
name: Fong, Kwun M.
name: Fonseca, Nuno A.
name: Foster, Christopher S.
name: Fox, Natalie S.
name: Fraser, Michael
name: Frazer, Scott
name: Frenkel-Morgenstern, Milana
name: Friedman, William
name: Frigola, Joan
name: Fronick, Catrina C.
name: Fujimoto, Akihiro
name: Fujita, Masashi
name: Fukayama, Masashi
name: Fulton, Lucinda A.
name: Furuta, Mayuko
name: Futreal, P. Andrew
name: Füllgrabe, Anja
name: Gabriel, Stacey B.
name: Gallinger, Steven
name: Gambacorti-Passerini, Carlo
name: Gao, Jianjiong
name: Garraway, Levi
name: Garred, Øystein
name: Garrison, Erik
name: Garsed, Dale W.
name: Gehlenborg, Nils
name: George, Joshy
name: Gerhard, Daniela S.
name: Gerhauser, Clarissa
name: Gershenwald, Jeffrey E.
name: Gerstung, Moritz
name: Ghori, Mohammed
name: Ghossein, Ronald
name: Giama, Nasra H.
name: Gibbs, Richard A.
name: Gill, Anthony J.
name: Gill, Pelvender
name: Giri, Dilip D.
name: Glodzik, Dominik
name: Gnanapragasam, Vincent J.
name: Goebler, Maria Elisabeth
name: Goldman, Mary J.
name: Gomez, Carmen
name: Gonzalez-Perez, Abel
name: Gordenin, Dmitry A.
name: Gossage, James
name: Gotoh, Kunihito
name: Govindan, Ramaswamy
name: Grabau, Dorthe
name: Graham, Janet S.
name: Grant, Robert C.
name: Green, Anthony R.
name: Green, Eric
name: Greger, Liliana
name: Grehan, Nicola
name: Grimaldi, Sonia
name: Grimmond, Sean M.
name: Grossman, Robert L.
name: Grundhoff, Adam
name: Gundem, Gunes
name: Guo, Qianyun
name: Gupta, Manaswi
name: Gupta, Shailja
name: Gut, Marta
name: Göke, Jonathan
name: Ha, Gavin
name: Haake, Andrea
name: Haan, David
name: Haas, Siegfried
name: Haase, Kerstin
name: Haber, James E.
name: Habermann, Nina
name: Haider, Syed
name: Hama, Natsuko
name: Hamdy, Freddie C.
name: Hamilton, Anne
name: Hamilton, Mark P.
name: Han, Leng
name: Hanna, George B.
name: Hansmann, Martin
name: Haradhvala, Nicholas J.
name: Harismendy, Olivier
name: Harliwong, Ivon
name: Harmanci, Arif O.
name: Harrington, Eoghan
name: Hasegawa, Takanori
name: Hawkins, Steve
name: Hayami, Shinya
name: Hayashi, Shuto
name: Hayes, D. Neil
name: Hayes, Stephen J.
name: Hayward, Nicholas K.
name: Hazell, Steven
name: He, Yao
name: Heath, Allison P.
name: Heath, Simon C.
name: Hedley, David
name: Hegde, Apurva M.
name: Heiman, David I.
name: Heins, Zachary
name: Heisler, Lawrence E.
name: Hellstrom-Lindberg, Eva
name: Helmy, Mohamed
name: Heo, Seong Gu
name: Hepperla, Austin J.
name: Heredia-Genestar, José María
name: Herrmann, Carl
name: Hersey, Peter
name: Hilmarsdottir, Holmfridur
name: Hirano, Satoshi
name: Hiraoka, Nobuyoshi
name: Hoadley, Katherine A.
name: Hobolth, Asger
name: Hodzic, Ermin
name: Hoell, Jessica I.
name: Hoffmann, Steve
name: Hofmann, Oliver
name: Holbrook, Andrea
name: Holik, Aliaksei Z.
name: Hollingsworth, Michael A.
name: Holmes, Oliver
name: Holt, Robert A.
name: Hong, Chen
name: Hong, Eun Pyo
name: Hong, Jongwhi H.
name: Hooijer, Gerrit K.
name: Hornshøj, Henrik
name: Hosoda, Fumie
name: Hou, Yong
name: Hovestadt, Volker
name: Howat, William
name: Hoyle, Alan P.
name: Hruban, Ralph H.
name: Hu, Jianhong
name: Hua, Xing
name: Huang, Kuan-Lin
name: Huang, Mei
name: Huang, Mi Ni
name: Huber, Wolfgang
name: Hudson, Thomas J.
name: Hummel, Michael
name: Hung, Jillian A.
name: Huntsman, David
name: Hupp, Ted R.
name: Huse, Jason
name: Huska, Matthew R.
name: Hübschmann, Daniel
name: Iacobuzio-Donahue, Christine A.
name: Imbusch, Charles David
name: Imielinski, Marcin
name: Imoto, Seiya
name: Isaacs, William B.
name: Isaev, Keren
name: Ishikawa, Shumpei
name: Iskar, Murat
name: Islam, S. M. Ashiqul
name: Ittmann, Michael
name: Ivkovic, Sinisa
name: Izarzugaza, Jose M. G.
name: Jacquemier, Jocelyne
name: Jakrot, Valerie
name: Jamieson, Nigel B.
name: Jang, Gun Ho
name: Jang, Se Jin
name: Jayaseelan, Joy C.
name: Jayasinghe, Reyka
name: Jefferys, Stuart R.
name: Jegalian, Karine
name: Jennings, Jennifer L.
name: Jeon, Seung-Hyup
name: Jerman, Lara
name: Ji, Yuan
name: Jiao, Wei
name: Johansson, Peter A.
name: Johns, Amber L.
name: Johns, Jeremy
name: Johnson, Rory
name: Johnson, Todd A.
name: Jolly, Clemency
name: Joly, Yann
name: Jonasson, Jon G.
name: Jones, Corbin D.
name: Jones, David T. W.
name: Jones, Nic
name: Jones, Steven J. M.
name: Jonkers, Jos
name: Ju, Young Seok
name: Juhl, Hartmut
name: Juul, Malene
name: Juul, Randi Istrup
name: Juul, Sissel
name: Kabbe, Rolf
name: Kahles, Andre
name: Kahraman, Abdullah
name: Kaiser, Vera B.
name: Kakavand, Hojabr
name: Kalimuthu, Sangeetha
name: Von Kalle, Christof
name: Kang, Koo Jeong
name: Karaszi, Katalin
name: Karlan, Beth
name: Karlić, Rosa
name: Karsch, Dennis
name: Kassahn, Karin S.
name: Katai, Hitoshi
name: Kato, Mamoru
name: Katoh, Hiroto
name: Kawakami, Yoshiiku
name: Kay, Jonathan D.
name: Kazakoff, Stephen H.
name: Kazanov, Marat D.
name: Keays, Maria
name: Kebebew, Electron
name: Kefford, Richard F.
name: Kellis, Manolis
name: Kench, James G.
name: Kennedy, Catherine J.
name: Kerssemakers, Jules N. A.
name: Khoo, David
name: Khoo, Vincent
name: Khuntikeo, Narong
name: Khurana, Ekta
name: Kilpinen, Helena
name: Kim, Hark Kyun
name: Kim, Hyung-Yong
name: Kim, Hyunghwan
name: Kim, Jaegil
name: Kim, Jihoon
name: Kim, Jong K.
name: Kim, Youngwook
name: King, Tari A.
name: Klapper, Wolfram
name: Klimczak, Leszek J.
name: Knappskog, Stian
name: Kneba, Michael
name: Knoppers, Bartha M.
name: Koh, Youngil
name: Komorowski, Jan
name: Komura, Daisuke
name: Komura, Mitsuhiro
name: Kong, Gu
name: Kool, Marcel
name: Korbel, Jan O.
name: Korchina, Viktoriya
name: Korshunov, Andrey
name: Koscher, Michael
name: Koster, Roelof
name: Kote-Jarai, Zsofia
name: Koures, Antonios
name: Kovacevic, Milena
name: Kremeyer, Barbara
name: Kretzmer, Helene
name: Kreuz, Markus
name: Krishnamurthy, Savitri
name: Kube, Dieter
name: Kumar, Kiran
name: Kumar, Pardeep
name: Kundra, Ritika
name: Kübler, Kirsten
name: Küppers, Ralf
name: Lagergren, Jesper
name: Lai, Phillip H.
name: Laird, Peter W.
name: Lakhani, Sunil R.
name: Lalonde, Emilie
name: Lamaze, Fabien C.
name: Lambert, Adam
name: Lander, Eric
name: Landgraf, Pablo
name: Landoni, Luca
name: Langerød, Anita
name: Lanzós, Andrés
name: Larsimont, Denis
name: Larsson, Erik
name: Lathrop, Mark
name: Lau, Loretta M. S.
name: Lawerenz, Chris
name: Lawlor, Rita T.
name: Lawrence, Michael S.
name: Lazar, Alexander J.
name: Le, Xuan
name: Lee, Darlene
name: Lee, Donghoon
name: Lee, Eunjung Alice
name: Lee, Hee Jin
name: Lee, Jake June-Koo
name: Lee, Jeong-Yeon
name: Lee, Juhee
name: Lee, Ming Ta Michael
name: Lee-Six, Henry
name: Lehmann, Kjong-Van
name: Lehrach, Hans
name: Lenze, Dido
name: Leonard, Conrad R.
name: Leongamornlert, Daniel A.
name: Letourneau, Louis
name: Levine, Douglas A.
name: Lewis, Lora
name: Ley, Tim
name: Li, Chang
name: Li, Constance H.
name: Li, Haiyan Irene
name: Li, Jun
name: Li, Lin
name: Li, Shantao
name: Li, Siliang
name: Li, Xiaobo
name: Li, Xiaotong
name: Li, Xinyue
name: Li, Yilong
name: Liang, Han
name: Liang, Sheng-Ben
name: Lichter, Peter
name: Lin, Pei
name: Lin, Ziao
name: Linehan, W. M.
name: Lingjærde, Ole Christian
name: Liu, Dongbing
name: Liu, Eric Minwei
name: Liu, Fei-Fei
name: Liu, Fenglin
name: Liu, Jia
name: Liu, Xingmin
name: Livingstone, Julie
name: Livni, Naomi
name: Lochovsky, Lucas
name: Loeffler, Markus
name: Long, Georgina V.
name: Lopez-Guillermo, Armando
name: Lou, Shaoke
name: Louis, David N.
name: Lovat, Laurence B.
name: Lu, Yiling
name: Lu, Yong-Jie
name: Lu, Youyong
name: Luchini, Claudio
name: Lungu, Ilinca
name: Luo, Xuemei
name: Luxton, Hayley J.
name: Lynch, Andy G.
name: Lype, Lisa
name: López, Cristina
name: López-Otín, Carlos
name: Ma, Yussanne
name: MacGrogan, Gaetan
name: MacRae, Shona
name: Macintyre, Geoff
name: Madsen, Tobias
name: Maejima, Kazuhiro
name: Mafficini, Andrea
name: Maglinte, Dennis T.
name: Maitra, Arindam
name: Majumder, Partha P.
name: Malcovati, Luca
name: Malikic, Salem
name: Malleo, Giuseppe
name: Mann, Graham J.
name: Mantovani-Löffler, Luisa
name: Marchal, Kathleen
name: Marchegiani, Giovanni
name: Mardis, Elaine R.
name: Margolin, Adam A.
name: Marin, Maximillian G.
name: Markowetz, Florian
name: Markowski, Julia
name: Marks, Jeffrey
name: Marques-Bonet, Tomas
name: Marra, Marco A.
name: Marsden, Luke
name: Martens, John W. M.
name: Martin, Sancha
name: Martin-Subero, Jose I.
name: Martincorena, Iñigo
name: Martinez-Fundichely, Alexander
name: Massie, Charlie E.
name: Matthew, Thomas J.
name: Matthews, Lucy
name: Mayer, Erik
name: Mayes, Simon
name: Mayo, Michael
name: Mbabaali, Faridah
name: McCune, Karen
name: McDermott, Ultan
name: McGillivray, Patrick D.
name: McPherson, John D.
name: McPherson, John R.
name: McPherson, Treasa A.
name: Meier, Samuel R.
name: Meng, Alice
name: Meng, Shaowu
name: Merrett, Neil D.
name: Merson, Sue
name: Meyerson, Matthew
name: Mieczkowski, Piotr A.
name: Mihaiescu, George L.
name: Mijalkovic, Sanja
name: Mijalkovic-Lazic, Ana Mijalkovic
name: Mikkelsen, Tom
name: Milella, Michele
name: Mileshkin, Linda
name: Miller, Christopher A.
name: Miller, David K.
name: Miller, Jessica K.
name: Minner, Sarah
name: Miotto, Marco
name: Arnau, Gisela Mir
name: Mirabello, Lisa
name: Mitchell, Chris
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Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Article
/631/1647/2217/748
/631/114/2399
/692/4028/67/69
/706/648/697/129/2043
/45/23
/139
article

description: Funder: NCI U24CA211006
description: Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF &lt; 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts.