cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Investigating the Role of Protein Arginine Methyltransferases in Breast Cancer Etiology
Creators: name: Morettin, Alan James
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Arginine Methylation
PRMTs
Breast Cancer

description: Breast cancer is the most commonly diagnosed cancer amongst Canadian women. Though numerous treatments are available, in many instances tumours become refractory or recur. Therefore, understanding the biological events that lead to the progression and therapeutic resistance of breast cancer is essential for the development of novel treatment options for this disease. Numerous members of the protein arginine methyltransferase (PRMT) family, which are the enzymes responsible for catalyzing methylation on arginine residues are aberrantly regulated in breast cancer. Hence, understanding the precise contribution of PRMTs to the development and progression of breast cancer is important. This Thesis will present my findings on the alternatively spliced PRMT1 isoform, PRMT1v2, previously identified to be overexpressed in breast cancer cell lines and here shown to promote breast cancer cell survival and invasion. Second, a novel role is ascribed to PRMT6, another PRMT aberrantly expressed in breast cancer. PRMT6 promotes chemoresistance to the drug bortezomib by mediating stress granule formation through down-regulation of eIF4E. Increased stress granule formation in bortezomib-resistant cancer cells promotes cell survival. Third, DDX3, a prototypical PRMT substrate which is overexpressed in breast cancer cell lines and stimulates transformation of mammary epithelial cells is a novel substrate of PRMT1, CARM1, and PRMT6. Lastly, TDRD3, a reader/effector of arginine methylation also overexpressed in breast tumours regulates breast cancer cell proliferation, anchorage-independent growth and cell motility and invasion.
Characteristics, Main Impacts, and Stewardship of Natural and Artificial Freshwater Environments: Consequences for Biodiversity Conservation
Creators: name: Cantonati, Marco
name: Poikane, Sandra
name: Pringle, Catherine M.
name: Stevens, Lawrence E.
name: Turak, Eren
name: Heino, Jani
name: Richardson, John Stuart
name: Bolpagni, Rossano
name: Borrini, Alex
name: Cid, Núria
name: Čtvrtlíková, Martina
name: Galassi, Diana M. P.
name: Hájek, Michal
name: Hawes, Ian
name: Levkov, Zlatko
name: Naselli-Flores, Luigi
name: Saber, Abdullah A.
name: Cicco, Mattia Di
name: Fiasca, Barbara
name: Hamilton, Paul B.
name: Kubečka, Jan
name: Segadelli, Stefano
name: Znachor, Petr
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2020

description: In this overview (introductory article to a special issue including 14 papers), we consider all main types of natural and artificial inland freshwater habitas (fwh). For each type, we identify the main biodiversity patterns and ecological features, human impacts on the system and environmental issues, and discuss ways to use this information to improve stewardship. Examples of selected key biodiversity/ecological features (habitat type): narrow endemics, sensitive (groundwater and GDEs); crenobionts, LIHRes (springs); unidirectional flow, nutrient spiraling (streams); naturally turbid, floodplains, large-bodied species (large rivers); depth-variation in benthic communities (lakes); endemism and diversity (ancient lakes); threatened, sensitive species (oxbow lakes, SWE); diverse, reduced littoral (reservoirs); cold-adapted species (Boreal and Arctic fwh); endemism, depauperate (Antarctic fwh); flood pulse, intermittent wetlands, biggest river basins (tropical fwh); variable hydrologic regime—periods of drying, flash floods (arid-climate fwh). Selected impacts: eutrophication and other pollution, hydrologic modifications, overexploitation, habitat destruction, invasive species, salinization. Climate change is a threat multiplier, and it is important to quantify resistance, resilience, and recovery to assess the strategic role of the different types of freshwater ecosystems and their value for biodiversity conservation. Effective conservation solutions are dependent on an understanding of connectivity between different freshwater ecosystems (including related terrestrial, coastal and marine systems).
Alcoholism treatment digest (Release No. 79, April 15, 1966)
Creators: name: Keller, Mark
Publisher: name: No Publisher Supplied
Year: 1966

description: The Alcoholism Treatment Digest was a subscription-based publication prepared for special clients by the editorial department of the Quarterly Journal of Studies on Alcohol / Journal of Studies on Alcohol from 1950 to 1973 with Mark Keller as editor. It was published in February, April, June, October, and December, summarizing scholarly content on four topics, available to republish with attribution. Some of the reviews were simultaneously published in the "Connecticut Review on Alcoholism" under the identical subtitle "Alcoholism Treatment Digest" every other month. The authors of the reviews were first noted in 1964, in the June issue.Contents, Release No. 791.Alcohol, Alcoholism and Suicide2.Outpatient Management of Acutely Ill Alcoholics 3.Evaluating Clinic Treatment4.Alcoholism: Crime or Disease? 5.The Fate of Untreated Alcoholics
Estimità/intimità: tra pulsioni e passioni dell'essere
Creators: name: Bottiroli, Giovanni
Publisher: name: Facoltà di Lettere e Filosofia - Università degli Studi di Milano
Year: 2010

description: Per la cultura del Novecento, la nozione di «interiorità» non è una nozione ovvia. Al contrario: i pensatori più innovativi l’hanno messa radicalmente in discussione. Heidegger rifiuta l’idea di un soggetto incapsulato, che dovrebbe aprirsi al mondo esterno; Freud teorizza un soggetto diviso, definito da processi di identificazione, cioè da un rapporto costitutivo con l’alterità. Si può dunque sostenere che la nozione di interiorità è accettabile solo nella prospettiva (pre-freudiana) di un soggetto indiviso.Secondo Lacan (Seminario VII), l’intimità del soggetto è abitata dall’estimità, cioè da un’esteriorità opaca che eccede ogni tentativo di padronanza e di trasparenza. Nell’estimità, nel dinamismo elastico delle pulsioni, dobbiamo probabilmente individuare la causa delle scissioni nel soggetto. Queste scissioni sono modi d’essere e modi di pensare. Il soggetto tenta di cucire le proprie lacerazioni, e coltiva il progetto impossibile di una coincidenza con se stesso; ma le pulsioni, e le passioni, lo trascinano oltre i propri confini.Alcune opere di Tolstoj vengono qui utilizzate per esemplificare il rapporto tra i registri lacaniani (immaginario, simbolico, reale): rapporto di intreccio e di conflitto, possibilità di inclusione paradossale. L’amore si rivela una  miscela instabile, eterogenea, anche nella sua forma media. Le forme estreme ripropongono la sudditanza a das Ding, la Cosa, l’esteriorità intima del soggetto.
description: ENTHYMEMA, N° 2 (2010)
Stand der Klärschlammtrocknung und Klärschlammverbrennung in Deutschland
Creators: name: Heidecke, Patric
name: Six, Jörg
name: Lehrmann, Falko
Publisher: name: My University
Year: 2018
Subjects: Klärschlamm
Phosphorrecycling
Trocknung
Verbrennung

description: Die Verteilung von stofflicher und thermischer Verwertung kommunaler Klärschlämme hat sich von 2007 bis 2016 von einer Gleichverteilung zugunsten der thermischen Behandlung verschoben. Aufgrund jüngster gesetzlicher Änderungen ist zusätzlich ein deutlicher Trend hin zur thermischen Behandlung von Klärschlamm zu erkennen. Die Autoren setzen sich mit dem Status quo der Vorbehandlungsanlagen (Trocknung) sowie den thermischen Behandlungsanlagen auseinander. Der Artikel stellt den aktuellen Stand der in Deutschland betriebenen Trocknungs- und Monoverbrennungsanlagen dar, bilanziert den Bedarf an Verbrennungsanlagen auf Länderebene und soll unter Einbeziehung der Mitverbrennungsanlagen (Kohlekraftwerke, Müllverbrennungsanlagen und Zementwerke) eine Entscheidungshilfe sein für die Errichtung neuer Monoverbrennungsanlagen. Die bekannten Projekte werden in diese Matrix mit aufgenommen. Quelle: Verlagsinformation
description: The breakdown of recycling and energy recovery of municipal sewage sludge tipped from a balance to favour thermal treatment between 2007 and 2016. In addition, a clear trend towards the thermal treatment of sewage sludge is evident based on the latest changes in the law. The authors address the status quota of pre-treatment technology (drying) and thermal treatment plants. This article depicts that current status for drying and mono-incineration facilities operated in Germany, balances the need for incineration plants at state level and should serve as a decision-making aid for the installation of new mono-incineration plants while considering co-incineration plants (coalfired power plants, dedicated waste-to-energy plants and cement kilns). Known projects will be included in this matrix. Quelle: Verlagsinformation
Formale Entwicklung der Steuerungssoftware für eine elektrisch ortsbediente Weiche mit VSE
Creators: name: Canver, Ercüment
name: Gayen, Jan-Tecker
name: Moik, Adam
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: DDC 004 / Data processing & computer science
subject: Digital control systems
subject: Digitale Steuerung
subject: Weiche

description: N/A
Communicating Sport Mega-Events and the Soft Power Dimensions of Public Diplomacy
Creators: name: Donos, Maxim
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: sport mega-events
public diplomacy
soft power
credibility
reputation
legitimacy
Olympic Games

description: Increased international competitiveness to host sport mega-events indicates their perceived value in stimulating regional and national economic, social and cultural development. In the context of broader governmental public opinion management strategies, sport mega-events hold the potential to mobilize soft power resources of the host country, expressed in values, culture and policies, and engage with and influence the publics of other countries. This thesis investigates the significance of sport mega-events for the host country’s public diplomacy strategies and practice by exploring the concepts of public diplomacy, sport mega-events, soft power and national image within a multi-disciplinary conceptual framework. The analysis of scholarly literature, official and media reports reveals how aspects of reputation, credibility, and legitimacy guide both foreign public opinion and the practice of public diplomacy in conjunction with sport mega-events. Moreover, international reputation of the host nation, including status, prestige and image, appeared to benefit the most as a result of strategic application of sport mega-events to public diplomacy. This can be achieved by proving functional reputation though demonstration of financial and organizational success. Alternatively, social reputation of the host is at risk of sustaining considerable damage as a result of resistance from social activists groups, thus requiring extensive damage control efforts of the host country's image. The conclusions drawn from this study raise significant questions about the potential of sport mega-events being effectively used for public diplomacy and the experience of the host governments, revealing functional competence as having the greatest potential to influence public diplomacy strategy built around hosting sport mega-events.
Supplementary document for Anomalous contrast in broadband THz near-field imaging of gold microstructures - 5199057.pdf
Creators: name: Pizzuto, Angela
name: Chen, Xinzhong
name: Hu, Hai
name: Dai, Qing
name: Liu, Mengkun
name: Mittleman, Daniel
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental Document
Considerazioni mimetiche su Il perturbante (Das Unheimliche)
Creators: name: Antonelli, Emanuele
Publisher: name: Facoltà di Lettere e Filosofia - Università degli Studi di Milano
Year: 2010

description: Si affronta una revisione della categoria psicanalitica del perturbante, con attenzione alla genesi della nozione nell’opera di Freud. Si propone quindi un’ipotesi di lettura, mediante applicazione del paradigma offerto dalla teoria mimetica di René Girard, al fine di rivedere le fondamenta antropologiche dell’esperienza codificata nel testo freudiano. Attraverso un’analisi etimologica del lemma italiano, si discute l’opportunità delle critiche rivolte alla traduzione originale, mettendo anzi in luce la complessità semantica di tale soluzione e le potenzialità esplicative che essa aggiunge alla già ampia, e nota, estensione del lemma tedesco. Con riferimento alla filosofia della storia di matrice girardiana, si mette a fuoco il ruolo della temporalità sia dal punto di vista della genesi della determinazione analitica, sia dal punto di vista delle condizioni di possibilità storiche dell’esperienza in esame.
description: ENTHYMEMA, N° 2 (2010)
A multi-national peer support intervention: the UPSIDES pilot phase
Creators: name: Nixdorf, Rebecca
name: Nugent, Lena
name: Aslam, Rabeea´H
name: Barber, Sarah
name: Charles, Ashleigh
name: Meir, Lion Gai
name: Grayzman, Alina
name: Hiltensperger, Ramona
name: Kalha, Jasmine
name: Korde, Palak
name: Mtei, Rachel
name: Niwemuhwezi, Jackie
name: Ramesh, Mary
name: Ryan, Grace
name: Slade, Mike
name: Wenzel, Lisa
name: Mahlke, Candelaria
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Peer support
subject: global mental health
subject: pilot phase
subject: implementation
subject: recovery
subject: DDC 150 / Psychology
subject: Mental health services
subject: Global health
subject: Peer group
subject: Empowerment
subject: Krisenintervention
subject: Psychische Gesundheit
subject: Peer-Group

description: Objective: Using Peer Support in Developing Empowering Mental Health Services (UPSIDES) is evaluating implementation of a peer support worker (PSW) intervention at six recruiting sites (Germany, India, Israel, Tanzania, and Uganda) (ISRCTN26008944). The aim of this study is to evaluate the pre-trial pilot phase. Method: The initial training to prepare individuals for the PSW role and the implementation of the peer support (PS) intervention was evaluated using a multi-method design comprising six focus groups (FG; n = 22) and questionnaires capturing the perspectives of service users, PSWs, peer trainers, and mental health staff members (n = 21). Results: Findings were organised across eleven key implementation themes: organisational culture, PSW training, PSW role definition, staff willingness and ability to work with PSWs, resource availability, financial arrangements, support for PSW well-being, PSW access to a peer network, acceptance, preparation, and other challenges. Discussion: The following recommendations aremade, based on this pilot phase: the PS training should train on practical skills using roleplaying exercises; PSWs should work in teams, including role reflection with colleagues (intervision) or with a highly experienced coach (supervision); necessary resources and tools for networking should be provided; and continuous awareness-raising about PS is needed.
title: Context and Factors in Acquiring Literacy Skills: A Case Study of Two Adult Literacy Classes in Namibia
Creators: name: Kahivere, Walter Naftalie
Publisher: name: University of Massachusetts Amherst
Year: 1996
Subjects: subject: Education

description: This study was conducted over a period of three and a half months in two Stage One literacy classes. The main aim of the study was to determine whether the National Literacy Program in Namibia is addressing the specific literacy needs of these two classes. The case study covers 35 learners in Windhoek. The study concluded that some learning did take place in the classes, if the results of final examination is something to go by. The attendance and dedication of the learners and the promoters was outstanding. However, this study noted that the learners came with a broader expectation to the class, than what the program had to offer. They did not only come to the class to learn how to read, write and count. They wanted to learn specific literacy skills that would help them to cope with specific situation in their daily lives. They also felt that they had something to contribute to the program, instead of only receiving. The teachers, who received a three week training course, used mostly the so-called "lecture method" to teach the primers. More than half of the content in the two primers deals with rural area issues. These learners found them inappropriate in their urban situation. This study concluded that the learners and teachers should be given more ownership and responsibility in the creation of text. This does not mean that the primers should be abolished. It only means that irrelevant parts could be supplemented with learner-generated and other existing materials.
Audiovisual Prior Entry: Evidence from the Synchrony Comparison Judgment Task
Creators: name: Capstick, Gary
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: prior entry
attention
temporal order judgment
synchrony comparison judgment
synchrony judgment
response bias

description: Prior entry refers to the notion that attended stimuli are perceived sooner than unattended stimuli due to a speed up in sensory processing. The century long debate regarding the prior entry phenomenon’s existence has always been grounded in the degree to which the methods applied to the problem allow for cognitive response bias. This thesis continues that trend by applying the synchrony comparison judgment method to the problem of audiovisual prior entry. Experiment 1 put this method into context with two other common psychophysical methods – the temporal order judgment and the synchrony judgment – that have been applied to the prior entry problem. The results of this experiment indicated that the temporal order judgment method was out of step with the other two methods in terms of the parameter estimates typically used to evaluate prior entry. Experiment 2 evaluated and confirmed that a specific response bias helps explain the difference in parameter estimates between the temporal order judgment method and the other two. Experiment 3 evaluated the precision of the synchrony comparison judgment method. The results indicated that the method was precise enough to detect potentially small prior entry effect sizes, and that it afforded the ability to detect those participants with points of subjective synchrony that deviate substantially from zero. Finally, Experiment 4 applied the synchrony comparison judgment method to a prior entry scenario. A prior entry effect was not realized. Overall, this thesis highlights the drawbacks of all previous methods used to evaluate audiovisual perception, including prior entry, and validates the use of the synchrony comparison judgment. Further, due to the resistance of this method to response bias, this result now stands as the most convincing evidence yet against the prior entry phenomenon.
Regulation of MHC I molecules in glioblastoma cells and the sensitizing of NK cells
Creators: name: Burster, Timo
name: Gärtner, Fabian
name: Bulach, Christiane
name: Zhanapiya, Anuar
name: Gihring, Adrian
name: Knippschild, Uwe
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: proteases
subject: NK cells
subject: DDC 570 / Life sciences
subject: Proteolytic enzymes
subject: Killer cells
subject: Immunotherapy
subject: Proteasen
subject: Natürliche Killerzelle
subject: MHC
subject: Kathepsin G
subject: Immuntherapie

description: Immunotherapy has been established as an important area in the therapy of malignant diseases. Immunogenicity sufficient for immune recognition and subsequent elimination can be bypassed by tumors through altered and/or reduced expression levels of major histocompatibility complex class I (MHC I) molecules. Natural killer (NK) cells can eliminate tumor cells in a MHC I antigen presentation-independent manner by an array of activating and inhibitory receptors, which are promising candidates for immunotherapy. Here we summarize the latest findings in recognizing and regulating MHC I molecules that affect NK cell surveillance of glioblastoma cells.
Positive autism : Drucker-based auto-ethnography inquiry of the employment retention of people with autism
Creators: name: Wong, Peter Sun San
Publisher: name: Southern Cross University
Year: 2020
Subjects: Positive autism
Productivity
Drucker
Strengths-focused employment
Evocative-analytic autoethnography

description: Introduction: Despite decades of deficit-based autism behavioural interventions and treatment, just 16 per cent of adults with autism are in full-time paid employment, and this situation is not improving.
description: Singling out people with autism by focusing on their deficits alone does not make sense. Wanting to change a person’s autistic behaviours is like attempting to correct left-handedness or sexual preference. It is cruel, unnatural and doomed to fail. It does not foster inclusion but emphasises exclusion. Instead autism researchers should move beyond studying autism as a deficit and emphasise the abilities and strengths of people with it. Research by the Gallup organisation shows people who use their strengths every day are 8 per cent more productive and 15 per cent less likely to quit their jobs, six times more likely to be engaged at work, and are three times more likely to report an excellent quality of life. Performance reviews that emphasise personal strengths improve organisational performance.
description: This study builds on a Drucker-based-strengths-focused innovation-driven management model to address employment retention issues for people with autism.
description: Research Questions:
description: 1. What are the workplace factors critical to employment retention of people with autism?
description: 2. How can employment retention for people with autism be improved?
description: Methodology: My academic method is combined evocative/analytic auto-ethnographic – involving deep reflection on my personal experiences over a lifetime of living with autism and connecting this experience to wider cultural, political and social understanding of interview participants.
description: Results and discussion: Three critical success factors for enhancing employment retention outcomes have emerged. First, build a knowledge-worker productivity workplace infrastructure to enable strengths. Second, stop workplace autism triggers. Third, promote strengths-focused management practices. This idea builds on Drucker’s theory of knowledge-worker productivity.
description: Significance: Understanding and addressing the organisational and structural mechanisms underpinning barriers to participation would inform efforts to redress social and health inequity through social action and our theoretical conceptualisation of disability and what it means to experience autism.
description: Conclusion and recommendation: We can change the significant social and employment disadvantage experienced by people with autism by seeing their assets rather than their liabilities. By rethinking management attitudes and practices, workplaces can harness as strengths and advantages the attributes that usually disadvantage people with autism.
Identité, modernité et nationalisme : le débat identitaire Canada-Québec selon Charles Taylor.
Creators: name: Defoy, Sébastien.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Canadian Studies.

description: La pensée du philosophe canadien Charles Taylor constitue une contribution majeure et originale à la réflexion sur l'identité et sa reconnaissance. Depuis bientôt quarante ans, son oeuvre traite des questions identitaires et nationales, notamment du débat Canada-Québec. Mon étude présente tout d'abord les éléments clés de la philosophie de Taylor: les éléments constitutifs de l'identité individuelle et collective, et sa méthode herméneutique. C'est à partir de ces éléments que Taylor propose sa lecture du débat identitaire Canada-Québec. On note une évolution de sa pensée depuis les années soixante jusqu'à l'échec de l'accord du lac Meech (1990). Taylor exige alors la reconnaissance de la nation québécoise par le reste du Canada, dans un pays entièrement redessiné. Par contre, depuis le second référendum sur la souveraineté du Québec (1995), Charles Taylor tient des propos qui exigent moins du Canada. Bref, il nous semble aujourd'hui que Taylor le politologue s'est éloigné de Taylor le philosophe.
Supplementary document for Anomalous contrast in broadband THz near-field imaging of gold microstructures - 5199057.pdf
Creators: name: Pizzuto, Angela
name: Chen, Xinzhong
name: Hu, Hai
name: Dai, Qing
name: Liu, Mengkun
name: Mittleman, Daniel
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: Supplemental Document
Identification of sequence elements required for replication and assembly of reovirus M1 gene and expression of the M1 gene in mammalian cells.
Creators: name: Zou, Shimian.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Biology, Molecular.

description: Reoviruses are double-stranded (ds) RNA viruses containing a genome of 10 dsRNA segments. A unique feature of reovirus replication is that each progeny virus contains one, and only one, of each of the 10 segments of dsRNA. However, the genetic elements that control the sorting and assembly of genome segments were not known. The M1 gene encodes the $\mu$2 protein which is a minor component of the virus core. Genetic studies have associated the M1 gene with cytopathic effect in cultured cells and pathogenesis in infected animals. The genetic basis for this function was not clear either. Because of the segmented nature of reovirus genome, coinfection of cells with two different serotypes can produce progeny viruses that contain genome segments from both serotypes (reassortants). Type 1 and type 3 reassortants that possess the type 3 L2 segment and type 1 M3 segment generate M1 segment deletion (smaller M1 segments) on serial passage (Brown et al., 1983). By analyzing reovirus M1 deletion mutants, it was found that both termini of the M1 gene were conserved. The results indicate that these two terminal regions contain all the genetic signals sufficient for the replication and assembly of the M1 gene and that 344 nucleotides could be the minimum length required for packaging into virions. Fifty-one nucleotide substitutions and 10 amino acid substitutions were identified between type 1 and type 3 M1 segments. These substitutions must be responsible for the phenotypic differences in cytopathic effect and pathogenesis that map to the M1 gene by genetic analyses. The M1 gene was further characterized by expression in mammalian cells. One $\mu$2-expressing L929 cell line was tested for its ability to support the growth of a reovirus temperature-sensitive (ts) mutant with a defect in its M1 gene. The restricted replication of the ts mutant at nonpermissive temperature was complemented by the $\mu$2-expressing cell line, demonstrating the feasibility of cultivating reoviruses with defective M1 genes. Mutagenesis of the M1 gene-containing DNA constructs and expression studies also clarified the translation initiation site of the M1 gene. It was found that translation of the M1 gene initiates from the first AUG codon starting at nucleotide 14 and that if there is initiation from AUG$\sb{161}$ as in 5$\sp\prime$-terminus-truncated constructs, a protein about 5 kDa smaller than $\mu$2 protein is produced. With the information about the M1 gene obtained from this study, preliminary reverse genetics work was initiated in attempts to further characterize the genetic signals within the conserved M1 termini and to develop reovirus as an expression vector. (Abstract shortened by UMI.)
«Humourism» in European Literature
Creators: name: Marcheschi, Daniela
Publisher: name: Facoltà di Lettere e Filosofia - Università degli Studi di Milano
Year: 2010

description: What is Tradition? We usually (and wrongly) think it coincides with History. It would be better to think of Traditions, that is various experiences that co-exist in history and can be picked up to build on one’s system of values to be passed on to future generations. Our knowledge is actually based on traditions, and literature makes no exception. In this paper the author shows how one tradition, i.e. the comic-humoristic one, has marked European culture and literature. Its extraordinary genealogy has been written down by Gerard de Nerval: from Apuleius through Petronius, Swift, Diderot, Voltaire, up to Lawrence Sterne. Nevertheless, in the course of time, the comic-humoristic tradition has been able to attract many other novelists, poets and artists who have brilliantly enriched our cultural experience. It is possible to go back to the nineteenth century and track down many lines of the comic-humoristic tradition acting in European cultures, in order to show their dynamics, their interactions and their influence even at the outset of children’s literature.
description: ENTHYMEMA, N° 2 (2010)
The Emergence of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs) as a Platform to Model Arrhythmogenic Diseases
Creators: name: Pourrier, Marc
name: Fedida, David
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2020

description: There is a need for improved in vitro models of inherited cardiac diseases to better understand basic cellular and molecular mechanisms and advance drug development. Most of these diseases are associated with arrhythmias, as a result of mutations in ion channel or ion channel-modulatory proteins. Thus far, the electrophysiological phenotype of these mutations has been typically studied using transgenic animal models and heterologous expression systems. Although they have played a major role in advancing the understanding of the pathophysiology of arrhythmogenesis, more physiological and predictive preclinical models are necessary to optimize the treatment strategy for individual patients. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have generated much interest as an alternative tool to model arrhythmogenic diseases. They provide a unique opportunity to recapitulate the native-like environment required for mutated proteins to reproduce the human cellular disease phenotype. However, it is also important to recognize the limitations of this technology, specifically their fetal electrophysiological phenotype, which differentiates them from adult human myocytes. In this review, we provide an overview of the major inherited arrhythmogenic cardiac diseases modeled using hiPSC-CMs and for which the cellular disease phenotype has been somewhat characterized.
Factor H autoantibodies and complement-mediated diseases
Creators: name: Zhang, Yuzhou
name: Ghiringhelli Borsa, Nicolo
name: Shao, Dingwu
name: Dopler, Arthur
name: Jones, Michael B.
name: Meyer, Nicole C.
name: Pitcher, Gabriella R.
name: Taylor, Amanda O.
name: Nester, Carla M.
name: Schmidt, Christoph Q.
name: Smith, Richard J. H.
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: factor H
subject: C3 glomerulopathy
subject: atypical hemolytic uremic syndrome
subject: monoclonal gammopathy of renal significance
subject: DDC 610 / Medicine & health
subject: Complement activation
subject: Autoantibodies
subject: Atypical hemolytic uremic syndrome
subject: Komplement
subject: Hämolytisch-urämisches Syndrom
subject: Autoantikörper

description: Factor H (FH), a member of the regulators-of-complement-activation (RCA) family of proteins, circulates in human plasma at concentrations of 180–420 mg/L where it controls the alternative pathway (AP) of complement in the fluid phase and on cell surfaces. When the regulatory function of FH is impaired, complement-mediated tissue injury and inflammation occur, leading to diseases such as atypical hemolytic uremic syndrome (a thrombotic microangiopathy or TMA), C3 glomerulopathy (C3G) and monoclonal gammopathy of renal significance (MGRS). A pathophysiological cause of compromised FH function is the development of autoantibodies to various domains of the FH protein. FH autoantibodies (FHAAs) are identified in 10.9% of patients with aHUS, 3.2% of patients with C3G, and rarely in patients with MGRS. The phenotypic variability of FHAA-mediated disease reflects both the complexity of FH and the epitope specificity of FHAA for select regions of the native protein. In this paper, we have characterized FHAA epitopes in a large cohort of patients diagnosed with TMA, C3G or MGRS. We explore the epitopes recognized by FHAAs in these diseases and the association of FHAAs with the genetic deletion of both copies of the CFHR1 gene to show how these disease phenotypes are associated with this diverse spectrum of autoantibodies.
Griffin and Sabine di Nick Bantock. Arte, racconto, scrittura e calligrafia.
Creators: name: Sindoni, Maria Grazia
Publisher: name: Facoltà di Lettere e Filosofia - Università degli Studi di Milano
Year: 2010

description: Questo contributo prende le mosse dalla problematica definizione di racconto, variamente interpretato in sede critico-letteraria di area inglese ed angloamericana. Si prenderà in esame un esempio che sfida tale categoria, Griffin and Sabine di Nick Bantock (1991), opera scritta e illustrata. Tale opera si configura come difficilmente inquadrabile in un genere letterario canonico di tradizione occidentale, perché si presenta come un carteggio «illustrato» fra i due personaggi protagonisti, raccogliendo un insieme di lettere e cartoline dipinte e variamente decorate. Le lettere sono inserite in buste postali cui il lettore ha accesso fisico. La lettura richiede manipolazioni operative preliminari, come l’apertura della busta, lo spiegamento e il tocco della carta, la decodifica della calligrafia dei personaggi. L’esperienza sensoriale a cui è sottoposto il lettore è rinforzata dall’ uso funzionale della calligrafia, che in quest’opera viene sfruttata in tutte le sue potenzialità espressive, per assumere connotati visivi ed estetici oltre che meramente comunicativi e referenziali. Infine, si suggeriranno possibili percorsi di lettura, che contemplino l’incorporamento dell’esperienza visiva e sensoriale a completamento del processo classico (intellettuale, cognitivo) di lettura dell’opera narrativa.
description: ENTHYMEMA, N° 2 (2010)
Supplementary document for Diffuse optical localization imaging (DOLI) enables noninvasive super-resolution brain angiography in the second near-infrared window - 5199757.pdf
Creators: name: Zhou, Quanyu
name: Chen, Zhenyue
name: ROBIN, Justine
name: DEÁN-BEN, XOSÉ
name: Razansky, Daniel
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement1
Wresting the crop from the traditional farmer: the entrepreneurial developer in new media business models
Creators: name: Rickard, Scott
Publisher: name: Swinburne
Year: 2024

description: Entrepreneurial social developers play a significant role in new media business models. Traditional media models operated within an environment where technology that enabled content production and provision, was owned and managed by the content producer. In new media models, this relationship is overturned. Entrepreneurial social developers have empowered end users by enabling them to become content producers. This has ensured that media companies are no longer the sole owners of tools that enable content production and provision. What end users have previously lacked is the skill to create a method of dissemination. During the last five years, entrepreneurial developers have acted as conduits providing end users with access to web based platforms such as Facebook, and sites that assist in the dissemination of end user content and which now also promote social networks, such as video (YouTube), photographs (Flickr), text by blog (WordPress) and micro blogs (Twitter). Entrepreneurial developers have provided platforms and web sites for user-generated content to be disseminated and possibly form part of a package of content provided by business organisations to their end users and consumers. This paper outlines some new media models that are emerging as a result of these innovative developments. It suggests that there are four models of macro integration, 'gregarious', 'friendly', 'solitary' and 'neighbourly'. The fourth model 'neighbourly' introduces FarmVille as a case study to illustrate the trend of social games like FarmVille, and how the tactics they apply to engage users can be applied in other areas.
Cycle decompositions of pathwidth‐6 graphs
Creators: name: Fuchs, Elke
name: Gellert, Laura
name: Heinrich, Irene
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: circuit
subject: cycle decomposition
subject: Hajós conjecture
subject: DDC 500 / Natural sciences & mathematics
subject: Decomposition (Mathematics)
subject: Eulerian graph theory
subject: Schaltzeichen
subject: Zerlegung, Mathematik
subject: Eulerscher Graph

description: Hajós' conjecture asserts that a simple Eulerian graph on n vertices can be decomposed into at most ⌊(n-1)/2⌋ cycles. The conjecture is only proved for graph classes in which every element contains vertices of degree 2 or 4. We develop new techniques to construct cycle decompositions. They work on the common neighborhood of two degree-6 vertices. With these techniques, we find structures that cannot occur in a minimal counterexample to Hajós' conjecture and verify the conjecture for Eulerian graphs of pathwidth at most 6. This implies that these graphs satisfy the small cycle double cover conjecture.
The impacts of climate change on the quality, availability and distribution of nutrients derived from harvested marine resources in south-eastern Australia
Creators: name: Shalders, Tanika
Publisher: name: Southern Cross University
Year: 2023
Subjects: Climate change
Ocean warming
Marine heatwaves
Seafood quality
Nutritional quality
Fisheries

description: Climate-driven environmental change is increasingly impacting marine ecosystems, global fisheries and marine resource use, whilst concomitantly, global reliance on seafood as a source of nutrition is increasing. Marine resources provide a broad range of economic, social and cultural benefits while delivering essential contributions to nutrient security and human health. In an emerging research frontier that intersects climate change ecology and fisheries science, my thesis aims to build knowledge on the impacts of current and near-future climate change on the quality, availability and distribution of nutrients derived from harvested marine resources in south-eastern Australia. I conducted a review of the literature, manipulative tank and mesocosm experiments and field-based sampling on four key species, seaweeds Ecklonia radiata and Sargassum linearifolium, eastern school prawn Metapenaeus macleayi and eastern school whiting Sillago flindersi. Throughout the thesis, I use a range of tools to tackle this topic including proximate and elemental analysis, lipid- and metabolomics, statistical modelling and spatial predictions. Combined, the results show that the quality and availability of nutrients can change within and between species and across spatial and temporal distributions. Overall my thesis supports the growing body of evidence that climate-driven environmental change has the potential to impact the content of important nutrients within marine species and therefore availability to marine ecosystems and consumers. My findings highlight the potential negative implications these changes could have for nutrient security, human health, trophic food webs, ecosystem function, and sustainable fisheries. I anticipate that the outcomes of my thesis will stimulate further interest and study of climate impacts on the nutritional quality of marine ecosystems and harvested resources.
An Analysis of Head Impact angle on the Dynamic Response of a Hybrid III Headform and Brain Tissue Deformation
Creators: name: Oeur, Anna
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: head impact
impact angle
Hybrid III
finite element analysis

description: The objective of this research was to better understand how impact angle influences headform dynamic response and brain tissue deformation. A bare headform was impacted using a pneumatic linear impactor at 5.5 m/s. The impacts were directed on the front and side location at angles of 0, 5, 10 and 15° rightward rotations as well as -5, -10 and -15° (leftward) rotations at the side to examine the characteristics of the head and neckform on the results. Peak resultant linear and rotational accelerations from the headform as well as peak maximum principal strain (MPS) and von Mises stress (VMS) estimated from a brain finite element model were used to measure the effect of impact angle. Significant results were dependent upon the impact angle and location as well as the dependent variable used for comparison (p <0.05). Impact angle produced significant differences in rotational acceleration and MPS at both the front and side; however angle only had an effect on VMS and linear acceleration at the front and side locations, respectively. These findings show that the effect of impact angle is asymmetrical and is specific to the dependent variable. This study suggests that varying impact angle alone may not be as influential on headform dynamic response and brain tissue deformation and that the severity of an impact may be more of a function of how both location and angle create high risk conditions.
Modelling landfill degradation behaviour
Creators: name: Lamborn, Julia
Publisher: name: Swinburne
Year: 2024

description: Landfill gas is a term used to describe the mixture of gases created by the decomposition of waste within a landfill. A landfill gas generation model is a tool that describes in simple terms the complex changes that occur during decomposition of waste in a landfill. The majority of simple models take into account microbial growth and decay only. The more complex models (known as component models) include not only microbial growth and decay, but also liquid, gas and heat transport through the waste, settlement and the chemical reactions that take place within the landfill. The majority of these models have been verified using laboratory scale data only and are highly parameter hungry. Landfill operators are very unlikely to use such complex models; since the majority of the required parameters are expensive and difficult to obtain at full-scale, or the historical data required to obtain them has never been collected. A better model for full-scale landfills is required based on the more sophisticated component models, but with fewer parameters, and able to be used by operators. To work towards developing such a model, an investigation is required examining existing models to determine the effect of the data set scale on the predictions from models and the sensitivity of the input parameters. An explanation of the processes involved in the generation of landfill gas, and a comparison of existing landfill models is presented. This thesis compares the predictions from five landfill models: two state of the art component models, a commonly used simple microbial growth and decay model and two simple Monod degradation models developed by the author. The scope of this thesis is the examination of the degradation component of landfill models and not subsequent transport and settlement components. The five models were selected to examine the parameter sensitivity of the various models at three different scales: laboratory scale: HPM2 challenge, UK (0.15 m3), field test cell: Brogborough test cells, UK (20,000 m3) and full-scale: Narre Warren landfill, Australia (3.5 x106 m3). Detailed information on the three data sets is provided. Relationships are developed between the critical model input parameters and the cumulative gas generation. These developed relationships will aid in the selection of input parameters for other landfills. The most sensitive input parameters required for the prediction of measured values were found to be the growth rates for simple models and the lytic and/or hydrolysis parameters for the more complex models. The selected models were assessed to see if they were able to predict measured gas generation at field-test cell and full-scale; in particular the component models, which had been developed and calibrated only at laboratory scale. Only one of the five models, LDAT, was unable to predict all three data sets.
Laicità, radici cristiane e regolamentazione del fenomeno religioso nella dimensione dell’U.E.
Creators: name: Varnier, Giovanni B.
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2011

description: Relazione presentata al Convegno su “L’Unione Europea dopo la riforma di Lisbona del 18 ottobre 2007” (Spoleto, 29 novembre 2007) organizzato dal Centro Internazionale per lo Studio del Diritto Comparato della Facoltà di Giurisprudenza dell’Università degli Studi di Urbino “Carlo Bo”.SOMMARIO: 1. L’Europa tra laicità e laicismo – 2. Distinzione e collaborazione tra Stato e confessioni religiose – 3. La disciplina del fenomeno religioso a livello europeo – 4. Il fronte islamico – 5. La dimensione universale della Chiesa cattolica – 6. Considerazioni conclusive.
description: Stato, Chiese e pluralismo confessionale, 2008: 3 giugno
Heaven and hell at the Paradise Motel, and Heaven and hell : sunburn and psychic shadows : gothic/noir in the contemporary Australian landscape. Exegesis only.
Creators: name: Chudy, Tessa Sere
Publisher: name: Southern Cross University
Year: 2014
Subjects: Gothic
Noir
Australian landscape

description: My Creative Research PhD thesis consists of a major creative work, a novel, and an exegesis. The novel, Heaven and Hell at the Paradise Motel, is preoccupied with the natural environment, its subtle seasonal changes and the way the environment impacts on its human inhabitants and how they in turn affect it. The accompanying exegesis explores the themes and ideas that informed the creative work. The main focus of the exegesis is Gothic and Noir. The construction of Gothic and Noir as both distinct and overlapping; historically, and within the context of the regional Australian landscape; and as a battered sublime, are explored in depth as well as their role in the construction of the novel.
Proceedings of the Understanding Timor-Leste 2019 Conference, Volume 1
Creators: name: Farram, Steven
name: da Silva, Dulce Martins
name: Soares, Leonardo F.
name: Mendes, Nuno Canas
name: Fernandes, Clinton
name: Soares, Mica Barreto
name: Pinto, Uka
name: Loney, Hannah
name: Williams, Robert L.
name: Nabais, Claudino Ninas
name: Leach, Michael
Publisher: name: Swinburne
Year: 2024

description: The peer-reviewed papers included in these volumes were first presented at the Timor-Leste Studies Association (TLSA)’s Understanding Timor-Leste 2019, which was held at the Universidade Nacional Timor-Lorosa’e (UNTL), Liceu Campus, Avenida Cidade de Lisboa, Dili, Timor-Leste, 27–28 June 2019. This was the 7th TLSA conference, following our conferences in Melbourne (2005) and Dili (2009, 2011, 2013, 2015 and 2017). More than 200 East Timorese and international delegates presented papers over two days. The conference was organised into three language streams, with papers presented in Tetum, Portuguese and English. This approach reflects the linguistic diversity of Timor-Leste and proved a great success.