Metadata supporting the published article: Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients.
Creators: name: Bohlok, Ali
name: Vermeulen, Peter
name: Leduc, Sophia
name: Latacz, Emily
name: Botzenhart, Lara
name: Richard, François
name: Schepper, Maxim De
name: Geukens, Tatjana
name: Lucidi, Valerio
name: Ignatiadis, Michail
name: Aftimos, Philippe
name: Sotiriou, Christos
name: Piccart, Martine
name: Hendlisz, Alain
name: Laere, Steven Van
name: Dirix, Luc
name: Jean-Christophe Noël
name: Biganzoli, Elia
name: Larsimont, Denis
name: Desmedt, Christine
name: Donckier, Vincent
Publisher: name: figshare
Year: 2020
Subjects: subject: Biological Techniques
subject: Cancer
subject: 111204 Cancer Therapy (excl. Chemotherapy and Radiation Therapy)
subject: FOS: Clinical medicine
subject: FOS: Clinical medicine
subject: Medicine
subject: 111299 Oncology and Carcinogenesis not elsewhere classified

description: Currently, there are no markers to identify patients with liver-only or liver-dominant metastases that would benefit from hepatic surgery. In this study, the authors characterized histopathological growth patterns (HGP) of liver metastases in a consecutive series of 36 breast cancer patients who underwent hepatic surgery.<br> <b>Data access: </b>The datasets that support the findings of this study are not publicly available, but will be made available upon reasonable request, following ethics committee approval and a data transfer agreement, to guarantee the General Data Protection Regulation. Please contact the corresponding author, Dr. Vincent Donckier (email address: vincent.donckier@bordet.be) to request access to the data.<br> <b>Study approval and patient consent: </b>This study was approved by the ethical committee of both institutions (CE2953 on the 5th of March 2019 for Institut Bordet and P2019/232/NA on the 4th of April 2019 for the Hôpital Erasme) and the necessity for written informed consent was waived given the retrospective nature of the study. <b>Study aims and methodology</b>: Even if metastatic breast cancer is frequently considered as a systemic disease, local treatment targeting metastases may result in prolonged survival in selected cases. In particular, in patients with liver-only or liver-dominant metastases, surgical resection of liver metastases (LM) is associated with survival between 22 and 61 months and long-term progression free survival in selected cases, serving as a proof-of-concept for an oligometastatic status in a subgroup of patients. In large retrospective studies, the histopathological growth patterns (HGP) of resected LM of patients with colorectal cancer predict the postoperative outcome, clearly surpassing the prognostic power of the traditional clinical risk scores. In this study, the authors aimed at scoring and evaluating the prognostic value of HGP in patients with breast cancer undergoing resection of LM. Consecutive patients with breast cancer who underwent surgical resection for LM at the Institut Jules Bordet and the Hôpital Erasme (Brussels, Belgium) between April 2000 and October 2017 were included in the study. This resulted in 36 patients with a median follow-up of 10,7 years. A total of 175 slides were evaluated for the LM from these 36 patients. The HGP of the LM was scored according to the international guidelines by an experienced pathologist (P.V.) blinded to the outcome data. All available H&amp;E-sections of all metastases were scored for each patient. The entire tumor–liver interface was evaluated for each tissue section. The HGP was scored as a relative proportion (percentage) of the interface in which each of the HGPs (replacement or desmoplastic) occurred. Average HGP scores were then calculated for each patient. For more details on the methodology, please read the related article.<br> <b>Datasets supporting the findings of this study: </b>Dataset <b>RetrospectiveDataOliverNPJBC.xls</b> is in .<b>xls</b> file format, and contains individual clinical and histopathological data (including the scores provided by the pathologists examining the H &amp; E sections).<br>