cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
FKBP51 Null Mice Are Resistant to Diet-Induced Obesity and the PPARγ Agonist Rosiglitazone
Creators: name: Najjar, Sonia M.
name: Hinds, Terry D.
name: Khuder, Saja S.
name: Yong, Weidong
name: Warrier, Manya
name: Russo, Lucia
name: Qiu, Bin
name: Gu, Hao
name: Stechschulte, Lance A.
name: Zhang, Man
name: Xu, Yuxue
name: Lecka-Czernik, Beata
name: Sanchez, Edwin R.
Publisher: name: The Endocrine Society
Year: 2016

description: FK506-binding protein-51 (FKBP51) is a molecular cochaperone recently shown to be a positive regulator of peroxisome proliferator-activated receptor (PPAR)γ, the master regulator of adipocyte differentiation and function. In cellular models of adipogenesis, loss of FKBP51 not only reduced PPARγ activity but also reduced lipid accumulation, suggesting that FKBP51 knock-out (KO) mice might have insufficient development of adipose tissue and lipid storage ability. This model was tested by examining wild-type (WT) and FKBP51-KO mice under regular and high-fat diet conditions. Under both diets, FKBP51-KO mice were resistant to weight gain, hepatic steatosis, and had greatly reduced white adipose tissue (WAT) but higher amounts of brown adipose tissue. Under high-fat diet, KO mice were highly resistant to adiposity and exhibited reduced plasma lipids and elevated glucose and insulin tolerance. Profiling of perigonadal and sc WAT revealed elevated expression of brown adipose tissue lineage genes in KO mice that correlated increased energy expenditure and a shift of substrate oxidation to carbohydrates, as measured by indirect calorimetry. To directly test PPARγ involvement, WT and KO mice were fed rosiglitazone agonist. In WT mice, rosiglitazone induced whole-body weight gain, increased WAT mass, a shift of substrate oxidation to lipids, and elevated expression of PPARγ-regulated lipogenic genes in WAT. In contrast, KO mice had reduced rosiglitazone responses for these parameters. Our results identify FKBP51 as an important regulator of PPARγ in WAT and as a potential new target in the treatment of obesity and diabetes.
Significance of Mast Cell Formed Extracellular Traps in Microbial Defense
Creators: name: Elieh-Ali-Komi, Daniel
name: Kuebler, Wolfgang M.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Extracellular traps
subject: LL-37
subject: Mast cells
subject: Microbial defense
subject: ROS
subject: Tryptase
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Mast cells (MCs) are critically involved in microbial defense by releasing antimicrobial peptides (such as cathelicidin LL-37 and defensins) and phagocytosis of microbes. In past years, it has become evident that in addition MCs may eliminate invading pathogens by ejection of web-like structures of DNA strands embedded with proteins known together as extracellular traps (ETs). Upon stimulation of resting MCs with various microorganisms, their products (including superantigens and toxins), or synthetic chemicals, MCs become activated and enter into a multistage process that includes disintegration of the nuclear membrane, release of chromatin into the cytoplasm, adhesion of cytoplasmic granules on the emerging DNA web, and ejection of the complex into the extracellular space. This so-called ETosis is often associated with cell death of the producing MC, and the type of stimulus potentially determines the ratio of surviving vs. killed MCs. Comparison of different microorganisms with specific elimination characteristics such as S pyogenes (eliminated by MCs only through extracellular mechanisms), S aureus (removed by phagocytosis), fungi, and parasites has revealed important aspects of MC extracellular trap (MCET) biology. Molecular studies identified that the formation of MCET depends on NADPH oxidase-generated reactive oxygen species (ROS). In this review, we summarize the present state-of-the-art on the biological relevance of MCETosis, and its underlying molecular and cellular mechanisms. We also provide an overview over the techniques used to study the structure and function of MCETs, including electron microscopy and fluorescence microscopy using specific monoclonal antibodies (mAbs) to detect MCET-associated proteins such as tryptase and histones, and cell-impermeant DNA dyes for labeling of extracellular DNA. Comparing the type and biofunction of further MCET decorating proteins with ETs produced by other immune cells may help provide a better insight into MCET biology in the pathogenesis of autoimmune and inflammatory disorders as well as microbial defense.
МУДОФАА ВАЗИРЛИГИ ОРГАНЛАРИНИНГ МАЪМУРИЙ ИШ ЮРИТИШДАГИ ЎРНИ
Creators: name: Қушбоқов, Ш.Х.
name: Баҳодиров, Ш.Э.
Publisher: name: Zenodo
Year: 2025

description: Mudofaa vazirligi organlari ma’muriy huquqbuzarlik ishlarini yuritishda muhim o‘rin tutadi, xususan, harbiy xizmat bilan bog‘liq qonunbuzarliklarni ko‘rib chiqishda alohida vazifalarni bajarib, davlat xavfsizligi va harbiy intizomni ta’minlashga xizmat qiladi. O‘zbekiston Respublikasida Mudofaa vazirligining ma’muriy ish yuritish faoliyati “Ma’muriy javobgarlik to‘g‘risida”gi Kodeks (MJtK) va “O‘zbekiston Respublikasi Qurolli Kuchlari to‘g‘risida”gi qonunga asoslanadi. Ushbu jarayonda harbiy xizmatchilarning huquq va majburiyatlari, shuningdek, qonun ustuvorligini ta’minlash masalalari alohida e’tiborga olinadi. Xorijiy tajribalarni tahlil qilish orqali O‘zbekistondagi amaliyotni yanada takomillashtirish imkoniyatlarini ko‘rib chiqish mumkin.
The association between peak tricuspid regurgitation velocity and 1-year heart failure readmission in hospitalised patients with heart failure with preserved ejection fraction
Creators: name: Wang, Tianbo
name: Liu, Xiaohan
name: Zhang, Yue
name: Fang, Chenli
name: Xu, Junbo
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health
subject: Hematology
subject: Computational Biology

description: This study aimed to evaluate the association between peak tricuspid regurgitation velocity (TRV) and 1-year heart failure (HF) readmission in hospitalised patients with HF with preserved ejection fraction (HFpEF) because the impact of peak TRV on the short-term prognosis of these patients has been unclear. From January 2020 to December 2021, 513 hospitalised HFpEF patients age ≥ 60 years with 1-year follow-up were included in this study. Peak TRV was classified as normal (≤ 2.8 m/s) and high (> 2.8 m/s) value according to pulmonary hypertension probability. Approximately 68.23% of HFpEF patients had a high peak TRV value. In the final adjusted Cox regression model, peak TRV was still independently associated with HF readmission (HR: 1.74, 95% CI: 1.19–2.55, p = 0.004). Furthermore, patients with high peak TRV were also associated with an increased risk of HF readmission (HR: 2.30, 95% CI: 1.31–4.04, p = 0.004), compared to those with normal peak TRV. After inverse probability of weighting, the risk of HF readmission in patients with high peak TRV was 2.53 (95% CI: 1.35–4.75, p = 0.004) compared to those with normal peak TRV. Additionally, Subgroup analysis revealed very elderly patients, male, and patients with hypertension had a significantly worse prognosis. Peak TRV is independently associated with HF readmission in hospitalised HFpEF patients. High peak TRV has a higher risk of HF readmission in patients age ≥ 80 years, male and patients with hypertension, indicating that special attention should be paid to these patients.
Actinin-1 binds to the C-terminus of A2B adenosine receptor (A2BAR) and enhances A2BAR cell-surface expression.
Creators: name: Liu, Zhengzhao
name: Huang, Pingbo
name: Yu, Xiaojie
name: Hu, Wenbao
name: Sun, Ying
name: Ravid, Katya
name: Tarran, Robert
Publisher: name: Portland Press
Year: 2016

description: A2BAR (A2B adenosine receptor) has been implicated in several physiological conditions, such as allergic or inflammatory disorders, vasodilation, cell growth and epithelial electrolyte secretion. For mediating the protein-protein interactions of A2BAR, the receptor's C-terminus is recognized to be crucial. In the present study, we unexpectedly found that two point mutations in the A2BAR C-terminus (F297A and R298A) drastically impaired the expression of A2BAR protein by accelerating its degradation. Thus we tested the hypothesis that these two point mutations disrupt A2BAR's interaction with a protein essential for A2BAR stability. Our results show that both mutations disrupted the interaction of A2BAR with actinin-1, an actin-associated protein. Furthermore, actinin-1 binding stabilized the global and cell-surface expression of A2BAR. By contrast, actinin-4, another non-muscle actinin isoform, did not bind to A2BAR. Thus our findings reveal a previously unidentified regulatory mechanism of A2BAR abundance.
New Approaches in Drug Dependence: Opioids
Creators: name: Mielau, Juliane
name: Vogel, Marc
name: Gutwinski, Stefan
name: Mick, Inge
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Opiod substitution
subject: Heroin-assisted treatment
subject: Harm reduction
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose of Review: This article aims to provide an overview of standard and adjunctive treatment options in opioid dependence in consideration of therapy-refractory courses. The relevance of oral opioid substitution treatment (OST) and measures of harm reduction as well as heroin-assisted therapies are discussed alongside non-pharmacological approaches. Recent Findings: Currently, recommendation can be given for OST with methadone, buprenorphine, slow-release oral morphine (SROM), and levomethadone. Heroin-assisted treatment using diamorphine shall be considered as a cost-effective alternative for individuals not responding to the afore-mentioned opioid agonists in order to increase retention and reduce illicit opioid use. The modalities of application and the additional benefits of long-acting formulations of buprenorphine should be sufficiently transferred to clinicians and the eligible patients; simultaneously methods to improve planning of actions and self- management need to be refined. Regarding common primary outcomes in research on opioid treatment, evidence of the effectiveness of adjunctive psychological interventions is scarce. Summary: Maintaining a harm reduction approach in the treatment of opioid addiction, a larger range of formulations is available for the prescribers. Embedding the pharmacological, ideally individualized treatment into a holistic, structure-giving concept also requires a reduction of fragmentation of ancillary services available, drug policies, and treatment philosophies on a global scale.
Wavelength, dose, skin type and skin model related radical formation in skin
Creators: name: Meinke, Martina C.
name: Busch, L.
name: Lohan, Silke B.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: skin
subject: sun radiation
subject: radical formation
subject: Electron paramagnetic resonance (EPR) spectroscopy
subject: Lipid oxygen species
subject: Reactive oxygen species
subject: Sunscreen
subject: UVC
subject: Photodynamic therapy
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The exposure to sun radiation is indispensable to our health; however, a long-term and high exposure could lead to cell damage, erythema, premature skin aging, and promotion of skin tumors. An underlying pathomechanism is the formation of free radicals which may induce oxidative stress at elevated concentrations. Different skin models, such as porcine-, murine-, human- ex vivo skin, reconstructed human skin (RHS) and human skin in vivo, were investigated during and after irradiation using X- and L-band EPR spectroscopy within different spectral regions (UVC to NIR). The amount of radical formation was quantified with the spin probe PCA and the radical types were measured ex vivo with the spin trap DMPO. The radiation dose influences the types of radicals formed in the skin. While reactive oxygen species (ROS) are always pronounced at low doses, there is an increase in lipid oxygen species (LOS) at high doses. Furthermore, the radical types arise independent from the irradiation wavelength, whereas the general amount of radical formation differs with the irradiation wavelength. Heat pre-stressed porcine skin already starts with higher LOS values. Thus, the radical type ratio might be an indicator of stress and the reversal of ROS/LOS constitutes the point where positive stress turns into negative stress.Compared to light skin types, darker types produce less radicals in the ultraviolet, similar amounts in the visible and higher ones in the infrared spectral region, rendering skin type-specific sun protection a necessity.
title: ML models for Customer Relationship Analysis in Finance
Creators: name: Jia, Nan
name: Bagam, Lahari
name: Fabijanczyk, Patricia
Publisher: name: George Mason University
Year: 2022
Subjects: subject: Finance
subject: Machine learning

description: The purpose of this research project was to analyze customer complaint data from financial institutions and identify areas of opportunity for these institutions to improve their customer satisfaction rate. In addition to pointing out areas for improvement, this paper also looks into similar research and tries to understand if themes found in this analysis are consistent with those done by other researchers. Banking is an essential piece to everyday life for all people across the world. Banks need to ensure that their products and processes are simple and accessible to all. Although banks have a monopoly on our financial needs their desire to retain existing customers and gain new ones drives the necessity of providing excellent and timely customer service. The study was conducted using a dataset of over two million customer complaint records and examining what were the top three financial institutions receiving complaints and which products received them. In addition, other aspects of complaints such as state of origination was also looked at. Analysis was done using machine learning, python, tableau and other tools to show the data points and their correlation. Understanding the top financial institution's methods of handling customer complaints, we are able to make recommendations for further product improvements to increase customer satisfaction. Concluding the research project is a list of challenges and opportunities for further research projects. In addition, there are recommendations for the financial institutions investigated in this project on how to move forward from analyzing customer complaint data.
Association of age with the timing of acute spine surgery–effects on neurological outcome after traumatic spinal cord injury
Creators: name: Kopp, Marcel A.
name: Lübstorf, Tom
name: Blex, Christian
name: Schwab, Jan M.
name: Grittner, Ulrike
name: Auhuber, Thomas
name: Ekkernkamp, Axel
name: Niedeggen, Andreas
name: Prillip, Erik
name: Hoppe, Magdalena
name: Ludwig, Johanna
name: Kreutzträger, Martin
name: Liebscher, Thomas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Injury to surgery interval
subject: Secondary referral
subject: Age
subject: Demographic change
subject: Neurological outcome
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: To investigate the association of age with delay in spine surgery and the effects on neurological outcome after traumatic spinal cord injury (SCI). Methods: Ambispective cohort study (2011-2017) in n = 213 patients consecutively enrolled in a Level I trauma center with SCI care in a metropolitan region in Germany. Age-related differences in the injury to surgery interval and conditions associated with its delay (> 12 h after SCI) were explored using age categories or continuous variables and natural cubic splines. Effects of delayed surgery or age with outcome were analyzed using multiple logistic regression. Results: The median age of the study population was 58.8 years (42.0-74.6 IQR). Older age (>= 75y) was associated with a prolonged injury to surgery interval of 22.8 h (7.2-121.3) compared to 6.6 h (4.4-47.9) in younger patients (<= 44y). Main reasons for delayed surgery in older individuals were secondary referrals and multimorbidity. Shorter time span to surgery (<= 12 h) was associated with higher rates of ASIA impairment scale (AIS) conversion (OR 4.22, 95%CI 1.85-9.65), as mirrored by adjusted spline curves (< 20 h 20-25%, 20-60 h 10-20%, > 60 h < 10% probability of AIS conversion). In incomplete SCI, the probability of AIS conversion was lower in older patients [e.g., OR 0.09 (0.02-0.44) for'45-59y' vs.' <= 44y'], as confirmed by spline curves (< 40y 20-80%, >= 40y 5-20% probability). Conclusion: Older patient age complexifies surgical SCI care and research. Tackling secondary referral to Level I trauma centers and delayed spine surgery imposes as tangible opportunity to improve the outcome of older SCI patients.
Corrigendum to ‘Microvesicle-associated tissue factor procoagulant activity for the preoperative diagnosis of ovarian cancer”, [Thromb. Res. 141 (2016) 39–48]
Creators: name: Mahner, Sven
name: Amirkhosravi, Ali
name: Claussen, Carlota
name: Davila, Monica
name: Hisada, Yohei M.
name: Francis, John L.
name: Bokemeyer, Carsten
name: Lezius, Susanne
name: Schmalfeldt, Barbara
name: Langer, Florian
name: Rausch, Alma-Verena
name: Mackman, Nigel
Publisher: name: Elsevier
Year: 2016

description: N/A
Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension
Creators: name: Grabowski, Katja
name: Herlan, Laura
name: Witten, Anika
name: Qadri, Fatimunnisa
name: Eisenreich, Andreas
name: Lindner, Diana
name: Schädlich, Martin
name: Schulz, Angela
name: Subrova, Jana
name: Mhatre, Ketaki Nitin
name: Primessnig, Uwe
name: Plehm, Ralph
name: Linthout, Sophie Van
name: Escher, Felicitas
name: Bader, Michael
name: Stoll, Monika
name: Westermann, Dirk
name: Heinzel, Frank R.
name: Kreutz, Reinhold
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Cardiac hypertrophy
subject: Cpxm2
subject: DOCA-salt hypertension
subject: Genetics
subject: FOS: Biological sciences
subject: Knock-out mice
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Treatment of hypertension-mediated cardiac damage with left ventricular (LV) hypertrophy (LVH) and heart failure remains challenging. To identify novel targets, we performed comparative transcriptome analysis between genetic models derived from stroke-prone spontaneously hypertensive rats (SHRSP). Here, we identified carboxypeptidase X 2 (Cpxm2) as a genetic locus affecting LV mass. Analysis of isolated rat cardiomyocytes and cardiofibroblasts indicated Cpxm2 expression and intrinsic upregulation in genetic hypertension. Immunostaining indicated that CPXM2 associates with the t-tubule network of cardiomyocytes. The functional role of Cpxm2 was further investigated in Cpxm2-deficient (KO) and wild-type (WT) mice exposed to deoxycorticosterone acetate (DOCA). WT and KO animals developed severe and similar systolic hypertension in response to DOCA. WT mice developed severe LV damage, including increases in LV masses and diameters, impairment of LV systolic and diastolic function and reduced ejection fraction. These changes were significantly ameliorated or even normalized (i.e., ejection fraction) in KO-DOCA animals. LV transcriptome analysis showed a molecular cardiac hypertrophy/remodeling signature in WT but not KO mice with significant upregulation of 1234 transcripts, including Cpxm2, in response to DOCA. Analysis of endomyocardial biopsies from patients with cardiac hypertrophy indicated significant upregulation of CPXM2 expression. These data support further translational investigation of CPXM2.
title: Student Attitudes Towards Digital Admissions Marketing
Creators: name: Bunting, Andrew
Publisher: name: George Mason University
Year: 2019
Subjects: subject: College admissions
subject: Email marketing
subject: Undergraduate admissions
subject: Digital marketing
subject: Student choice

description: This thesis examined student attitudes towards receiving digital admissions marketing materials, and what influence these marketing efforts had on their decision to apply to a specific school. The study focused on overall attitudes concerning digital admissions marketing, and explored specific aspects of admissions email marketing that participants found to be more or less influential. A diverse group of students was selected for individual interviews using a purposeful sampling strategy to engage potential participants that fit the study’s eligibility criteria. Participant responses were examined within the framework of Chapman’s (1981) model on student college choice, and Hossler and Gallagher’s (1987) three-phase model of college choice, with a specific focus on the search phase.
Supplementary document for Direct wavefront sensing with a plenoptic sensor based on deep learning - 6321927.pdf
Creators: name: Hao, Chen
name: Zhang, Haobo
name: He, Yi
name: WEI, Ling
name: Yang, Jinsheng
name: Li, Xiqi
name: Linhai, Huang
name: Kai, Wei
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental material
Skillet Laureate
Creators: name: McFee, Philip
name: McFee, Michael
Publisher: name: Johns Hopkins University Press
Year: 2016

description: I’ve always enjoyed giving poetry readings. To me, each one is a literary entertainment,
a chance to hold the attention of listeners in a hospitable way, an opportunity
to engage and delight them with some well- chosen language. It doesn’t
matter if they don’t “get” the poem as they would when reading it on the page; it
doesn’t matter if they only remember a few lines, or a title or two. What matters is
that they’re hearing a fellow human being who did his best to get the best words in
the best order, to arrange them—precisely, inventively, and joyfully—into those
charged little worlds called poems.
Controlling and designing the binding properties of multivalent systems: a coarse-grained modelling and simulations approach
Creators: name: Visco, Daniele
Publisher: name: Imperial College London
Year: 2024

description: Multivalent systems have recently drawn increasing interest due to their unique capability of reacting ultrasensitively to small changes in the applied conditions. This property has been validated as a tool for a wide range of applications, spacing from diagnostics to nanomedicine: exploiting the multivalent supereselectivity, it is possible to improve accuracy in diagnostic methods or enhance the targeting of diseased cells in nanomedicine. This thesis extends the theoretical and computational framework of multivalent system, focusing on the case of multivalent colloids. Our modelling introduces novel details of multivalent colloids, allowing for the evaluation of their effect on supereselectivity. With this model, we implement MC simulations to predict the behaviour of multivalent systems in function of the parameters of interest. Specifically, we consider the effect of: reduced mobility of ligands and receptors; a realistic model of repulsion interactions; colloidal anisotropy; localization of ligands into patches. Using our model we also implemented simulations to predict the phase diagram of multivalent colloids, looking at the specific case of DNA Coated Colloids (DNACC). We implemented MC to compute the phase diagram of DNACC when in solution with linker molecules capable of forming bridges between colloidal pairs. This models the application of multivalent colloids as diagnostic tools, in which a phase transition of the colloids signals a specific biomarker in the analyte. We also modelled sample contamination introducing a distribution of interaction energies between colloids and linkers. Finally we adapted the theoretical framework for multivalency to model an experimental data produced by collaborators. We show that applying pure theory, one can predict experimental results with remarkable accuracy. Moreover, we derived a kinetic model for the absorption of multivalent colloids to a receptor decorated surface, validating it against experimental data. Our model captures experimental trends accurately providing new insights on the kinetics of multivalency.
Negative Posttraumatic Cognitions Color the Pathway from Event Centrality to Posttraumatic Stress Disorder Symptoms
Creators: name: Johanßen, Helen
name: Schoofs, Nikola
name: Kliegl, Reinhold
name: Bermpohl, Felix
name: Ülsmann, Dominik
name: Schulte-Herbrüggen, Olaf
name: Priebe, Kathlen
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Event centrality
subject: PTSD
subject: Posttraumatic cognitions
subject: Valence
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: The centrality of an event indicates the extent to which it becomes a core part of identity and life story. Event centrality (EC) has been shown to have a strong relationship with PTSD symptoms, which seems to be indirectly influenced by negative posttraumatic cognitions (PTC). However, research on this potential mediation and its causal links particularly with clinical samples is limited and essential to derive treatment implications. Methods: Pre- and posttreatment data of 103 day-unit patients with PTSD was examined using mediation analyses and structural equation modeling. Results: Negative PTC mediated the relationship between EC and PTSD symptoms, partially pre- and completely posttreatment. Within extended longitudinal analyses causal directions of the mediation pathways were not adequately interpretable due to unexpected suppression effects. Conclusions: The results suggest that EC may only have an indirect effect on PTSD symptoms through negative PTC. Thus, decreasing negative PTC which are connected to centralized events might be a key element for PTSD treatment. Thereby, transforming the cognitions' valence to more positive and constructive forms could be crucial rather than mere decentralization. Although suppression effects limited causal inferences, they do not contradict the mediation and further indicate potential interactional terms and a transformation of EC.
title: “Keep this unwritten history”: mapping African American family histories in “information wanted” advertisements, 1880-1900
Creators: name: Burns, Katherine
Publisher: name: The University of Edinburgh
Year: 2024
Subjects: subject: African American family histories
subject: 1880
subject: 1900
subject: African American family
subject: “Information Wanted” advertisements
subject: American Civil War

description: This thesis examines “Information Wanted” advertisements which formerly enslaved people used to reconnect with lost family members after the American Civil War. The advertisements are an underutilised historical resource and are vitally important for their portrayal of individual and collective social, emotional and political realities, particularly regarding the radical and revisionist ways in which they were used to record family histories. This thesis is underpinned by an interdisciplinary Black Feminist Studies methodology, particularly influenced by bell hooks’ concept of homeplace as a site of resistance, as well as Jennifer L. Morgan’s concept of ‘refusal.’ The largest scale examination of Information Wanted advertisements to date, this thesis focuses on advertisements in three weekly church-sponsored African American newspapers: the Christian Recorder, the Southwestern Christian Advocate and the Star of Zion from 1880 to 1900. It examines what the Information Wanted ads of the 1880s onwards reveal about the transition from enslavement to a freedom that was in name only for African Americans, specifically what they reveal about the “spirit of slavery” as summarised by Frederick Douglass. The ongoing dehumanising, persecutory and disenfranchising context of the post-emancipation era encouraged formerly enslaved people to turn to Information Wanted ads to memorialise their experiences, as well as the histories of kin who came before them, as a means of safeguarding Black genealogies and fighting against the white supremacist record. In the recording of such histories, this thesis considers the ways in which the advertisements were used by some as a form of mourning in order to consider their historical and cultural importance as monuments to enslavement. It is the key intellectual aim and social, political and cultural responsibility of this thesis to share the stories of Black lives otherwise lost to white supremacist dominant sites of history. My interdisciplinary Black Feminist Studies methodology brings the Information Wanted advertisements to the foreground to examine how they were used by formerly enslaved people to remember and record their ancestry.
Minimally invasive pancreatic surgery—will robotic surgery be the future?
Creators: name: Dittrich, Luca
name: Biebl, Matthias
name: Malinka, Thomas
name: Knoop, Michael
name: Pratschke, Johann
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Robot-assisted surgery
subject: Pancreatoduodenectomy
subject: Distal pancreatectomy
subject: Cost-effectiveness
subject: Review
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Due to the complexity of the procedures and the texture of the organ itself, pancreatic surgery remains a challenge in the field of visceral surgery. During the past decade, a minimally invasive approach to pancreatic surgery has gained distribution in clinical routine, extending from left-sided procedures to pancreatic head resections. While a laparoscopic approach has proven beneficial for many patients with left-sided pancreatic pathologies, the complex reconstruction in pancreas head resections remains worrisome with the laparoscopic approach. The robotic technique was established to overcome such technical constraints while preserving the advantages of the laparoscopic approach. Even though robotic systems are still in development, especially in pancreatoduodenectomy, the current literature demonstrates the feasibility of this approach and stable clinical and oncological outcomes compared to the open technique, albeit only under the condition of such operations being performed by specialist teams in a high-volume setting (>20 robotic pancreaticoduodenectomies per year). The aim of this review is to analyze the current evidence regarding a minimally invasive approach to pancreatic surgery and to review the potential of a robotic approach. Presently, there is still a scarcity of sound evidence and long-term oncological data regarding the role of minimally invasive and robotic pancreatic surgery in the literature, especially in the setting of pancreaticoduodenectomy.
Estimating animal populations and body sizes from burrows: Marine ecologists have their heads buried in the sand
Creators: name: Maslo, Brooke
name: Lastra, Mariano
name: Williams, Alan
name: Leon, Javier X.
name: Weston, Michael A.
name: Olds, Andrew D.
name: Peterson, Charles H.
name: Schlacher, Thomas A.
name: Lucrezi, Serena
name: Althaus, Franziska
name: Schoeman, David S.
name: Connolly, Rod M.
name: Gilby, Ben L.
name: Hyndes, Glenn A.
Publisher: name: Elsevier
Year: 2016

description: 1.Most ecological studies require knowledge of animal abundance, but it can be challenging and destructive of habitat to obtain accurate density estimates for cryptic species, such as crustaceans that tunnel deeply into the seafloor, beaches, or mudflats. Such fossorial species are, however, widely used in environmental impact assessments, requiring sampling techniques that are reliable, efficient, and environmentally benign for these species and environments. 2.Counting and measuring the entrances of burrows made by cryptic species is commonly employed to index population and body sizes of individuals. The fundamental premise is that burrow metrics consistently predict density and size. Here we review the evidence for this premise. We also review criteria for selecting among sampling methods: burrow counts, visual censuses, and physical collections. 3.A simple 1:1 correspondence between the number of holes and population size cannot be assumed. Occupancy rates, indexed by the slope of regression models, vary widely between species and among sites for the same species. Thus, ‘average’ or ‘typical’ occupancy rates should not be extrapolated from site- or species specific field validations and then be used as conversion factors in other situations. 4.Predictions of organism density made from burrow counts often have large uncertainty, being double to half of the predicted mean value. Whether such prediction uncertainty is ‘acceptable’ depends on investigators' judgements regarding the desired detectable effect sizes. 5.Regression models predicting body size from burrow entrance dimensions are more precise, but parameter estimates of most models are specific to species and subject to site-to-site variation within species. 6.These results emphasise the need to undertake thorough field validations of indirect census techniques that include tests of how sensitive predictive models are to changes in habitat conditions or human impacts. In addition, new technologies (e.g. drones, thermal-, acoustic- or chemical sensors) should be used to enhance visual census techniques of burrows and surface-active animals.
Electroconvulsive therapy for negative symptoms in schizophrenia: a literature review from 2000 to 2021
Creators: name: Zierhut, Marco M.
name: Bernard, Renaldo M.
name: Turner, Eleanor
name: Mohamad, Sara
name: Hahn, Eric
name: Bajbouj, Malek
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Electroconvulsive therapy
subject: ECT
subject: Schizophrenia
subject: Psychosis
subject: Negative symptoms
subject: Literature review
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Negative symptoms in schizophrenia remain a clinical challenge with small effect sizes and evidence for pharmacological or psychotherapeutic treatment approaches. Studies suggest that electroconvulsive therapy (ECT) holds some promise as a treatment option of often persistent negative symptoms with clinically meaningful effects. This review summarizes the existing evidence on the efficacy of ECT on negative symptoms in patients with schizophrenia. Thirty-five publications were included in this literature review comprising 21 studies, two meta-analyses, eight reviews and four case reports. Conclusions should be interpreted cautiously, given the small number and methodological shortcomings of the included publications with a variation of study designs and missing standardized protocols. Implications for future research and practice are critically discussed. Recommendations are given to provide more evidence that will meet the clinical challenge of reducing the negative symptoms in schizophrenia. Study designs that focus explicitly on negative symptoms and assess patients over longer follow up periods could be helpful. Future research should include control groups, and possibly establish international multicentered studies to get a sufficient study population. Findings suggest that patients with schizophrenia resistant to pharmacological treatment might benefit from ECT. A risk and benefit assessment speaks in favour of the ECT treatment. Future practice of ECT should include a combination treatment with antipsychotics. Whereas the use of anaesthetics and electrode placement does not seem to play a role, the recommendation regarding frequency of ECT treatments is currently three times a week, For the assessment of negative symptoms the assessment tool should be chosen carefully.
Gebruik van hybride zaden ter verbetering van de aardappelproductie
Creators: name: de Vries, Michiel
Publisher: name: Zenodo
Year: 2022
Subjects: SolACEPA

description: Probleem: Veredeling en vermeerdering van aardappel via pootgoed zijn trage processen in de conventionele veredeling (zie figuur 1.A). Als gevolg van de complexe genetica, de moeilijkheid om specifieke locaties aan te wijzen en de onvoorspelbaarheid van de veredeling, is er een gebrek aan genetische vooruitgang in aardappelopbrengst. De conventionele aardappelveredeling is afhankelijk van volumineus pootgoed. Dit is in de praktijk niet efficiënt, en het maakt het onmogelijk om schoon uitgangmateriaal te produceren. Oplossing: Hybride veredeling (Figuur 1.B) van diploïde aardappel is een oplossing om sneller te veredelen en schoon uitgangsmateriaal te verkrijgen. Eenvoudigere genetica maakt het mogelijk om gunstige eigenschappen sneller te combineren door veredeling. Specifieke gewenste eigenschappen, zoals resistentie tegen Phytophthora, kunnen relatief snel worden ingebracht door natuurlijke kruising. Vermenigvuldiging via echt zaad maakt het mogelijk om binnen twee jaar miljoenen ziektevrije zaden te produceren.
title: Characteristics and Career Decisions of Secondary Dual Language Teachers in the United States
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2021

description: The shortage of middle and high school Dual Language teachers is a major barrier to program sustainability. This study explores the demographic characteristics and factors in the career decisions of secondary Dual Language teachers. A national survey included items on teacher characteristics, factors in the initial decision to become a Dual Language teacher, and factors in ongoing career commitment. Results indicate that altruistic factors and a passion for the language they would teach are especially important for teachers choosing to join the field, and that positive and supportive work environments are key factors in career commitment. Four teacher typologies emerged based on social identity factors. Findings suggest teacher recruitment can be more effective by appealing to the desire to help students, improve society, and share a passion for the language they will teach. Similarly, teacher retention can be more effective by creating work environments supportive of teachers’ values and by regularly reinforcing and celebrating the program elements and outcomes that teachers say are most important.
НЕДЕМЕНТНЫЕ КОГНИТИВНЫЕ НАРУШЕНИЯ У ПОСТИНСУЛЬТНЫХ БОЛЬНЫХ
Creators: name: Маджидова, Я.Н.
name: Бижанова, А.Б.
Publisher: name: Zenodo
Year: 2025

description: Обследовали 75 пациентов, перенесших инсульт с когнитивными нарушениями (КН). Из них мужчин было 41, женщин – 34. Средний возраст больных составил 60,2±1,1 год, у мужчин – 59,1±1,3, у женщин – 61,1±1,2. Больные были разделены на 3 группы: субъективные КН (СКН), легкие (ЛКН) и умеренные КН (УКН). Когнитивные функции исследовались с помощью методик: MMSE-тест, МОСА-тест, FAB, тест «10 слов» проба Шульта, а также выявления когнитивных вызванных потенциалов.
Supplementary document for Metasurfaces integrated with a single-mode waveguide array for off-chip wavefront shaping - 6322022.pdf
Creators: name: Chen, Siyu
name: Huang, Jianzhi
name: Yin, Shengqi
name: Milosevic, Milan
name: Pi, Hailong
name: Yan, Jize
name: Chong, Harold
name: Fang, Xu
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary figures and tables
title: Article: Charles M. Harr, The Mortgage Banker, "New Financing for Planned Communities," September, 1969
Creators: name: Harr, Charles M.
Publisher: name: Mortgage Bankers Association of America
Year: 1969
Subjects: subject: New communities

description: Textual: article, copy with red pencil marks; 11” x 8.5” (27.9 cm x 21.6 cm)
description: Article by Charles M. Harr in The Mortgage Banker entitled "New Financing for Planned Communities" from September 1969. Harr, Assistant Secretary for Metropolitan Development for the Department of Housing and Urban Development, discusses the provisions of Title IV of the New Communities Act of 1968. Harr discusses how the federal guarantee will provide developers access to the capital needed to begin a new community project. Planned Community Archives Collection, 483.06
[Letter from Hu Lichao to Hu Shiding and Hu Maoguang]
[胡立朝致胡世定和胡茂光的信］
Creators: name: Hu, Lichao
Publisher: name: The University of British Columbia
Year: 2011

description: Hu Lichao asks Hu Shiding and Hu Maoguang to send him 30 sacks of sticky rice as soon as possible.
title: The Libraries at Mason, Spring 2018
title: The Libraries at Mason
titleType: AlternativeTitle
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University Libraries
Year: 2018

description: 2017 was quite a year. We dedicated our first named space in our Arlington Campus Library – the John N. Paden Nigerian/African Collection. We completed renovations on the second floor of the old Fenwick building, bringing our music collection together in a Music Library and launching our Digital Scholarship Center. And, with a Special Project Grant from the Osher Lifelong Learning Institute, we looked back at the Cuban Missile Crisis and expanded our Oral History Project archives.
Linkage between theory‐based measurement of organizational readiness for change and lessons learned conducting quality improvement–focused research
Creators: name: Shaw, Ryan J.
name: Roumie, Christianne L.
name: Rakley, Susan M.
name: Bosworth, Hayden B.
name: Bowen, Michael E.
name: Kravetz, Jeffrey D.
name: Oddone, Eugene Z.
name: Jackson, George L.
name: Del Monte, Pamela S.
name: Kirshner, Miriam A.
name: Weiner, Bryan J.
Publisher: name: Wiley
Year: 2016

description: Organizations have different levels of readiness to implement change in the patient care process. The Hypertension Telemedicine Nurse Implementation Project for Veterans (HTN-IMPROVE) is an example of an innovation that seeks to enhance delivery of care for patients with hypertension. We describe the link between organizational readiness for change (ORC), assessed as the project began, and barriers and facilitators occurring during the process of implementing a primary care innovation. Each of 3 Veterans Affairs medical centers provided a half-time nurse and implemented a nurse-delivered, telephone-based self-management support program for patients with uncontrolled hypertension. As the program was starting, we assessed the ORC and factors associated with ORC. On the basis of consensus of medical center and research partners, we enumerated implementation process barriers and facilitators. The primary ORC barrier was unclear long-term commitment of nursing to provide continued resources to the program. Three related barriers included the need to address: (1) competing organizational demands, (2) differing mechanisms to integrate new interventions into existing workload, and (3) methods for referring patients to disease and self-management support programs. Prior to full implementation, however, stakeholders identified a high level of commitment to conduct nurse-delivered interventions fully using their skills. There was also a significant commitment from the core implementation team and a desire to improve patient outcomes. These facilitators were observed during the implementation of HTN-IMPROVE. As demonstrated by the link between barriers to and facilitators of implementation anticipated though the evaluation of ORC and what was actually observed during the process of implementation, this project demonstrates the practical utility of assessing ORC prior to embarking on the implementation of significant new clinical innovations.
An interdisciplinary approach to understanding the characteristics and universality of magnetic enhancement in hydrocarbon reservoirs: a case study from the Wessex Basin, UK
Creators: name: Turney, Jack
Publisher: name: Imperial College London
Year: 2024

description: The enhancement of the rock magnetic signature at oil-water contacts (OWCs) provides an alternative tool for identifying the base of present-day and paleo-oil columns, to assess yield and reservoir fill history when traditional methods are inconclusive. This thesis uses the Wessex Basin petroleum system, UK, as a data-rich laboratory to identify the characteristics and universality of OWC magnetic enhancement and constrain if it can be used in conjunction with petroleum systems modelling to establish the extent of Cenozoic hydrocarbon remigration. Increased saturation magnetisation and magnetic susceptibility have been identified at the OWC in siliclastic and carbonate reservoirs at Wytch Farm. Potential magnetic paleocontacts (PCs) have also been observed above the OWC, indicating the formation of multiple stable OWCs. Magnetic measurements reveal an increase in ferromagnetic magnetite and paramagnetic vivianite at magnetic enhancements, suggesting they are a universal characteristic of magnetic OWCs. The iron sulphide greigite has previously been suggested to form at OWCs, however, thermodynamic modelling presented here predicts greigite is more likely to be stable in iron-rich, anoxic and alkaline and low-temperature conditions (< 25 °C), suggesting that it is unlikely to be preserved at the OWC at burial depths above 900 - 1000 m. Comparing magnetic observations with petroleum systems modelling shows a strong depth correlation with Late Cretaceous and present-day OWCs, indicating magnetic OWCs can be used to calibrate petroleum systems models. The Wytch Farm reservoir was charged in the Cretaceous via Creech, Bushey Farm and offshore conduits from the Bridport carrier bed. Cenozoic tilting to the east of ≤ 1◦ caused significant westerly remigration, particularly in offshore areas, and drastically reduced the size of the Wytch Farm Bridport structure. A deepening of the OWC and multiple magnetic enhancements at Wareham indicate the tilting was periodic, causing pulses of westerly spill from Wytch Farm.
Das Interesse von Mädchen an MINT stärken mithilfe der intoMINT-App : Ergebnisse der genderwissenschaftlichen Begleitung
Creators: name: Scheidat, Tobias
name: Marschik, Grit
name: Böhnke, Stephanie
name: Pippirs, Lisa
name: Bade, Korinna
Publisher: name: Köthen
Year: 2021
Subjects: subject: Bewusstsein
subject: Wissenschaft
subject: MINT
subject: Mädchen
subject: Geschlechterrolle
subject: MINT-Interessenförderung
subject: Gamification
subject: Smartphone-App

description: Allein im MINT-Bereich fehlen der deutschen Wirtschaft über 105.000 Fachkräfte (Stand 2020). Gleichzeitig ist bei MINT-Berufen ein deutliches Ungleichgewicht beim zahlenmäßigen Verhältnis von Berufseinsteiger*innen zu Ungunsten der Frauen festzustellen. Die intoMINT-App stellt ein Instrument dar, mit dem speziell Mädchen und junge Frauen motiviert werden, sich aktiv und unvoreingenommen mit MINT auseinanderzusetzen und ihnen dabei Perspektiven für ihre berufliche Zukunft im MINT-Bereich aufzuzeigen. Die von uns entwickelte Smartphone App bietet eine Vielzahl von spannenden Experimenten und Projekten aus allen MINT-Bereichen. Diese werden angereichert mit Informationen zur Wissensvertiefung sowie zu spannenden Berufsbildern und Tätigkeitsfeldern. Motivierende Gamification-Elemente und individuelles Feedback von Expert*innen regen zum Ausprobieren an. Im Artikel werden die App und ihre Gestaltungselemente vorgestellt, die Ergebnisse der genderwissenschaftlichen Begleitungsforschung dargestellt und die Wirksamkeit nachgewiesen.