cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 3 of TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
Creators: name: De Magis, Alessio
name: Schult, Philipp
name: Schönleber, Antonia
name: Linke, Rebecca
name: Ludwig, Kerstin U.
name: Kümmerer, Beate M.
name: Paeschke, Katrin
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 3. Treatments with PDS and CX-5461 induce increase in cell mortality and G4s stabilization. a) Vitality assay (MTT) in Caco-2 (left graph) and MCF-7 (right graph) cell lines treated 24, 48 and 72 h with different concentrations of PDS (0 – 100μM). b) Vitality assay (MTT) in Caco-2 (left graph) and MCF-7 (right graph) cell lines treated 24, 48 and 72 h with different concentrations of CX-5461 (0 – 20μM). c) IF staining of Caco-2 cells, treated 24, 48 and 72 h with different concentrations of PDS (0 – 50μM), and stained with BG4 antibody (green), and DAPI (Nucleus border is defined by white borders). Scale bar, 10 µm. Below, quantification of BG4 signal in the nucleus of the cells. d) IF staining of MCF-7 cells, treated 24 h with different concentrations of PDS (0 – 50μM), and stained with BG4 antibody (green), and DAPI (Nucleus border is defined by white borders). Scale bar, 10 µm. Below, quantification of BG4 signal in the nucleus of the cells. The graphs in c) and d) show mean fluorescence intensity (MFI) levels normalized over untreated cells of n=3 biological independent experiments. Horizontal line represents the mean value. Significance was determined using an ordinary one-way ANOVA multiple comparison. Asterisks indicate statistical significance; in detail, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
The effect of medium and cold preconditioning on in vitro carpogenic germination of sclerotia of different Sclerotinia sclerotiorum isolates in New Zealand
Creators: name: Dassanayaka, Madhavi P.
name: Casonato, Seona G.
name: Jones, Eirian
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Sclerotia of Sclerotinia sclerotiorum germinate carpogenically developing apothecia and release ascospores which act as an inoculum in the field. Identifying the factors influencing the carpogenic germination of sclerotia is important in management of the pathogen. This study assessed the effect of medium and cold preconditioning on in vitro carpogenic germination of sclerotia and development of apothecia. Carpogenic germination was tested in sand, water agar and potting mixture and the effect of preconditioning of sclerotia at 4°C was assessed for isolates originating from different locations in New Zealand. Sclerotia germination and number of apothecia per plate were greater in water agar compared with potting mix. Development of stipes into apothecia was greater in compost compared with water agar. The isolates from sub-tropical Auckland region showed greater carpogenic germination than most of the isolates from temperate Canterbury region under the experimental conditions used in the study. A few isolates showed a positive or negative response to cold preconditioning hence, no conclusions as to possible ecological adaptation of S. sclerotiorum to the field conditions in which the isolates originated could be made. The prominent isolate effect on all aspects of carpogenic germination assessed highlights the need to include several isolates in future studies.
SOD_supplemental_online_document – Supplemental material for A New Measure of Research Participant Burden
Creators: name: Lingler, Jennifer H.
name: Schmidt, Karen L.
name: Gentry, Amanda L.
name: Hu, Lu
name: Terhorst, Lauren A.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, SOD_supplemental_online_document for A New Measure of Research Participant Burden by Jennifer H. Lingler, Karen L. Schmidt, Amanda L. Gentry, Lu Hu and Lauren A. Terhorst in Journal of Empirical Research on Human Research Ethics
Revisitando o conceito de Desenvolvimento Econômico e a Escola de Pensamento do Desenvolvimentismo na Economia
Creators: name: Albertin de Moraes, Isaías
Publisher: name: Humanities Commons
Year: 2023

description: O presente trabalho tem como objetivo revisitar e sistematizar os conceitos de Desenvolvimento Econômico e o de Desenvolvimentismo. A hipótese levantada pela pesquisa é a de que em razão da processualidade histórico-social das Ciências Econômicas, os termos Desenvolvimento Econômico e Desenvolvimentismo podem ser categorizados de forma distinta por opção epistemológica e didática na atualidade. O artigo optou por realizar um estudo bibliográfico. Os procedimentos metodológicos para selecionar as referências foram pesquisa bibliográfica focada nos autores com análise histórica, concreta e indutiva da economia e do fenômeno de desenvolvimento econômico. Os resultados obtidos são de que os termos Desenvolvimento Econômico e Desenvolvimentismo podem ser categorizados de forma distinta, o primeiro como conceito empregado por diversas escolas do pensamento econômico; o segundo é uma Escola de Pensamento Econômico em si e que possui quatro correntes teóricas (Desenvolvimentismo Clássico, Social Desenvolvimentismo, Novo Desenvolvimentismo, Desenvolvimentismo Socialista de Mercado).
Additional file 4 of TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
Creators: name: De Magis, Alessio
name: Schult, Philipp
name: Schönleber, Antonia
name: Linke, Rebecca
name: Ludwig, Kerstin U.
name: Kümmerer, Beate M.
name: Paeschke, Katrin
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 4. Treatments with CX-5461 induce G4s stabilization. a) IF staining of Caco-2 cells, treated 24, 48 and 72 h with different concentrations of CX-5461 (0 – 2μM), and stained with BG4 antibody (green), and DAPI (Nucleus border is defined by white borders). Scale bar, 10 µm. Below, quantification of BG4 signal in the nucleus of the cells. b) IF staining of MCF-7 cells, treated 24, 48 and 72 h with different concentrations of CX-5461 (0 – 2μM), and stained with BG4 antibody (green), and DAPI (Nucleus border is defined by white borders). Scale bar, 10 µm. Below, quantification of BG4 signal in the nucleus of the cells. The graphs in a) and b) show mean fluorescence intensity (MFI) levels normalized over untreated cells of n=3 biological independent experiments. Horizontal line represents the mean value. Significance was determined using an ordinary one-way ANOVA multiple comparison. Asterisks indicate statistical significance; in detail, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. c) Expression levels of isoform 1 and 2 in MCF-7 cell line treated 48 and 72 h with 1 or 2μM PDS. mRNA levels in the graphs were normalized to the level of U6 snRNA and GAPDH. WT mRNA levels were scaled to 100%. Error bars represent SEM of at least n=3 biological independent experiments.
Sorption and residue analysis of phosphine in fruits and vegetables
Creators: name: Kathpalia, Anisha
name: Arora, Sumitra
name: Sharma, Jai Gopal
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: This study investigated the sorption and residues of phosphine in fruits and vegetables relevant for export. Sorption patterns varied among the commodities: mango exhibited a constant sorption range of 10–12%, bitter gourd displayed a distinct pattern with peak sorption of 20% at 8 hours, and chilli demonstrated a higher range of sorption percentage, peaking at 60% at 8 hours. ANOVA (F (4,8) = 0.449, p = 0.771) and regression (F (1,11) = 0.851, p = 0.376) analysis revealed a non-significant relationship between the sorption percentage and exposure period. Residue analysis using Gas Chromatography with FPD detector revealed relatively low levels of phosphine residues in mango (0.009–0.01 µL/L), negligible traces in chilli samples, residues within the maximum residue limit (MRL) range for bitter gourd after 4–6 hours of aeration. Detecting phosphine residues within acceptable limits underscores the significance of post-fumigation protocols to meet stringent food safety standards, thereby safeguarding product integrity for global trade. Therefore, phosphine fumigation could serve as a viable alternative to methyl bromide fumigation for quarantine treatment of perishables as it doesn’t leave detectable toxic residues in produce following aeration and has no role in ozone depletion thus making it a more sustainable solution for international trade in fresh produce.
Ioannes/John Kolobos (John the Little, or John the Dwarf), ascetic of Sketis and monastic founder
Creators: name: Admin, CSLA
Publisher: name: University of Oxford
Year: 2018
Subjects: History

description: All evidence related to Ioannes/John Kolobos (John the Little, or John the Dwarf), ascetic of Sketis and monastic founder.
Screening of Arsenic toxicity in Oryza sativa L. (rice) and assessment of variation in growth, ROS, and antioxidant responses in tolerant and sensitive rice cultivars
Creators: name: Khan, Zesmin
name: Chowdhury, Devasish
name: Upadhyaya, Hrishikesh
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: Arsenic (As) in rice plants has toxic effects on their quality and human health. In the present study, 100 rice cultivars have been screened in hydroponics to analyze As toxicity and select As-tolerant and sensitive rice cultivars. The findings showed that rice cultivars responded differently to As stress at varying levels of effect. As treatments significantly changed morphological traits, the arsenic tolerance index (ATI %), pigments, and H2O2 concentrations. The rice cultivars Luit and Swarna demonstrated remarkable results (tolerant and sensitive) in terms of growth, as well as in terms of ATI, chlorophyll content, H2O2 content, and enzymatic and non-enzymatic antioxidants. Arsenic-induced pigment degradation and antioxidant content reduction were greater in Swarna than in Luit. Moreover, the results of biochemical analysis correlated with the morphological parameters. The selected As-tolerant and sensitive cultivars may be used to explore the tolerance mechanism in greater depth, which will require further molecular investigations.
PECULIARITIES OF TRAINING PROFESSIONAL JUNIOR BACHELORS DURING QUARANTINE EVENTS IN RELATION TO PANDEMIC COVID-19
Creators: name: Gorikhovskyi, Maksym
name: Oganesyan, Valerik
name: Oganesyan, Valerik
name: Oganesyan, Valerik
name: Oganesyan, Valerik
Publisher: name: Humanities Commons
Year: 2022

description: The article is devoted to one of the urgent problems of training applicants for vocational education in conditions of quarantine restrictions and general quarantine in Ukraine. It has been substantiated that distance learning technologies are an effective means of supporting the educational process during quarantine restrictions. It has been established that during distance learning of applicants for vocational higher education, digital educational resources should be used that provide high-quality informational support for training, as well as network communication tools through which participants in the educational process communicate. It was investigated that the choice of resources to support distance learning of future specialists is influenced by the peculiarities of their professional training, in particular, for paramedics, the need to demonstrate biological objects and phenomena, that it is necessary to take into account the technical and didactic capabilities of educational platforms, online services and other digital resources were used in professional training, for specialists in finance, banking and insurance, there is a need to demonstrate phenomena and trends. The main resource that was used for informational support of the educational process, carrying out control activities through testing and interaction of participants in the educational process was a modular object-oriented dynamic learning environment. The training sessions in the video conferencing mode were provided by the cloud service Google Meet and Skype meet now, practical classes and seminars were held in different platforms depending on the specifics of the subject and topic Moodle, Skype meet now, Viber, Google Meet and Google Classroom.
Reviewer_2_v.1 – Supplemental material for Impact of baseline COPD symptom severity on the benefit from dual versus mono-bronchodilators: an analysis of the EMAX randomised controlled trial
Creators: name: Vogelmeier, Claus F.
name: Kerwin, Edward M.
name: Bjermer, Leif H.
name: Tombs, Lee
name: Jones, Paul W.
name: Boucot, Isabelle H.
name: Naya, Ian P.
name: Lipson, David A.
name: Compton, Chris
name: Barnes, Neil
name: Maltais, François
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine
subject: 110203 Respiratory Diseases

description: Supplemental material, Reviewer_2_v.1 for Impact of baseline COPD symptom severity on the benefit from dual versus mono-bronchodilators: an analysis of the EMAX randomised controlled trial by Claus F. Vogelmeier, Edward M. Kerwin, Leif H. Bjermer, Lee Tombs, Paul W. Jones, Isabelle H. Boucot, Ian P. Naya, David A. Lipson, Chris Compton, Neil Barnes and François Maltais in Therapeutic Advances in Respiratory Disease
Genotype-environment interaction in maize hybrids: a multivariate relationship between yield components, morphological variables and disease tolerance
Creators: name: de Freitas Souza, Matheus
name: de Paiva Filho, Silvio Vasconcelos
name: Policarpo, Victor Hugo Custodio
name: Braz, Guilherme Braga Pereira
name: Simon, Gustavo André
name: Silva, Daniel Valadão
name: do Carmo, Eduardo Lima
name: Solino, Antônio Jussiê
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology
subject: Virology

description: Knowledge of phenotypical variables, yield and susceptibility to diseases may clarify why some hybrids are more productive than others. In this study, we evaluated the stability and responsiveness of genotype-environment interactions on phenological variables, yield components and susceptibility to diseases of maize hybrids. Experiments were conducted in 5 regions in the Brazilian Midwest. Two population were used for each hybrid in each region, totalling 10 systems-environments. Data were analysed by Restricted Maximum Likelihood; Best Unbiased Linear Prediction and Principal Components Analysis. Environmental conditions and plant populations affect the yield components of maize hybrids. Variations equal to 57,000 and 62,700 plants ha−1 was relatively small and may not have been large enough to reveal plant density effects on disease. Diseases reduced the yield of hybrids with greater susceptibility to these phytopathogens at some sites, despite the use of fungicides. The best performance for at least two yield component variables resulted in the highest yield. Microclimate control using plant populations was omitted as a management option for reducing the severity and incidence of diseases for the tested conditions in this work. The climatic conditions of agricultural sites increased the incidence and severity of diseases, mainly of Cercospora zeae maydis.
Economia Criativa nos países do Mercosul: breve análise conjuntural
Creators: name: Albertin de Moraes, Isaías
name: Albertin de Moraes, Isaías
Publisher: name: Humanities Commons
Year: 2023

description: O presente artigo tem como objetivo pesquisar a situação do setor de Indústria Criativa nos países membros do Mercado Comum do Sul (Mercosul) no período que vai de 2012 a 2015. No que tange à metodologia, optou-se pela análise crítica de dados bibliográficos e documentais, trabalhando com estatísticas coletadas na UNCTAD, BID e FIRJAN e conceitos de Economia Criativa (EC) elaborados por autores renomados como Howkins, Florida e Throsby. O trabalho está dividido em duas partes:  na primeira, apresenta-se a evolução operacional do conceito de EC e, na segunda, examinam-se os dados referentes ao setor da EC no Mercosul. A conclusão, comparando com outros países do mundo, é de que a EC é uma alternativa promissora de desenvolvimento econômico, porém ainda pouco explorada pelo Mercosul.
Additional file 5 of TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
Creators: name: De Magis, Alessio
name: Schult, Philipp
name: Schönleber, Antonia
name: Linke, Rebecca
name: Ludwig, Kerstin U.
name: Kümmerer, Beate M.
name: Paeschke, Katrin
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 5. G4s modulate TMPRSS2 expression and SARS-CoV-2 replication. a) Time course experiments of MCF-7 cells pre- treated 24 h with 1μM CX-5461 or 10μM PDS and electroporated with the SARS-CoV-2 non-infectious replicon [52]. Luciferase plate was read at time points 0, 12, 18 and 24 h. b) Western blot analysis of protein extracts from Caco-2 cells transfected with siRNAs against TMPRSS2 isoform 1 and 2 and only isoform 2. Membrane was stained with anti-Tmprss2 and anti-Histone 3 antibodies. The original gel is reported in Additional file 9 c) SARS-CoV-2 replication in Calu-3 cells transfected with siRNAs against TMPRSS2 isoform 1 and 2, only isoform 2 and scramble siRNA or treated 24 h with PDS (10 μM), CX-5461 (1 μM), and Camostat Mesylate (25μM). Luciferase activity was measured 24 h after electroporation with the SARS-CoV2 non-infectious replicon [52]. d) ThT (left panel) and EtBr (right panel) staining of the oligonucleotide harboring G4s in the exon1 of the isoform 1 and 2 as well as oligonucleotide with mutations in order to disrupt the G4 motifs run in a 15% TBE native gels. e) NMM (left panel) and EtBr (right panel) staining of the oligonucleotide harboring G4s in the exon1 of the isoform 1 and 2 as well as oligonucleotide with mutations in order to disrupt the G4 motifs run in a 15% TBE native gels. f) HeLa cells transfected with psiCHECK™-2 vector containing DNA oligonucleotides harboring the predicted G4 motifs at the exon 1 of the isoform 1, the G-rich sequence in the isoform 2 as well as control mutated sequences cloned upstream of the reporter gene. Expression of psiCHECK™-2 was normalized to the G4_exon1_Iso1.
Reviewer_1_v.1 – Supplemental material for The use of nebulized pharmacotherapies during the COVID-19 pandemic
Creators: name: Sethi, Sanjay
name: Barjaktarevic, Igor Z.
name: Tashkin, Donald P.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine
subject: 110203 Respiratory Diseases

description: Supplemental material, Reviewer_1_v.1 for The use of nebulized pharmacotherapies during the COVID-19 pandemic by Sanjay Sethi, Igor Z. Barjaktarevic and Donald P. Tashkin in Therapeutic Advances in Respiratory Disease
Additional file 6 of TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
Creators: name: De Magis, Alessio
name: Schult, Philipp
name: Schönleber, Antonia
name: Linke, Rebecca
name: Ludwig, Kerstin U.
name: Kümmerer, Beate M.
name: Paeschke, Katrin
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 6. DNA oligonucleotides harboring the G4 motifs in the exon 1 of the isoform 1 and in a G-rich region of isoform 2. as well as control sequences containing mutations within the PQS that are predicted, in silico, to prevent G4 formation.
Supplemental Material, sj-pdf-1-ear-10.1177_0145561320973777 - Olfactory Dysfunction in Patients With Relapsing-Remitting Multiple Sclerosis Treated With Disease-Modifying Therapies
Creators: name: Wnuk, Marcin
name: Drabik, Leszek
name: Marona, Monika
name: Szaleniec, Joanna
name: Bryll, Amira
name: Karczk, Paulina
name: Kolasinska, Justyna
name: Kolasinska, Monika
name: Ziekiewicz, Maciej
name: Skladzien, Jacek
name: Popiela, Tadeusz
name: Slowik, Agnieszka
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110315 Otorhinolaryngology
subject: FOS: Clinical medicine

description: Supplemental Material, sj-pdf-1-ear-10.1177_0145561320973777 for Olfactory Dysfunction in Patients With Relapsing-Remitting Multiple Sclerosis Treated With Disease-Modifying Therapies by Marcin Wnuk, Leszek Drabik, Monika Marona, Joanna Szaleniec, Amira Bryll, Paulina Karczk, Justyna Kolasinska, Monika Kolasinska, Maciej Ziekiewicz, Jacek Skladzien, Tadeusz Popiela and Agnieszka Slowik in Ear, Nose & Throat Journal
Pan-Americanismo e Cinema durante a Política Externa da boa Vizinhança (1933-1945) no Brasil os embaixadores Disney, Orson Welles e Carmen Miranda
Creators: name: Albertin de Moraes, Isaías
name: Albertin de Moraes, Isaías
Publisher: name: Humanities Commons
Year: 2021

description: O artigo procura relacionar algumas películas cinematográfica financiadas pelo Estados Unidos da América (EUA) durante sua Política Externa da Boa Vizinhança (1933 ”“ 1945) mediante o Office of the Coordinator of Inter-American Affairs (OCIAA) com o conceito de pan-americanismo. A hipótese elencada pela pesquisa é que o uso do cinema como instrumento do soft power da Política Externa de Boa Vizinhança, ao apregoar o pan-americanismo, o American Way of Life, e ao procurar conter a influência ideológica nazifascista na América Latina, auxiliou na construção de uma identidade positiva nas relações EUA-Brasil. A pesquisa emprega como procedimentos metodológicos a consulta de fontes primárias e secundárias. O artigo, assim, embasa em autores renomados e em pesquisa documental realizada em importantes centros e bibliotecas tanto do Brasil quanto dos EUA. A pesquisa permitiu com que o texto tenha transcrições de entrevistas e de discursos ”“ poucos divulgados pela academia ”“ de personalidades da época, proporcionando uma correlação singular com a produção bibliográfica sobre a temática e uma argumentação original.  A conclusão que o artigo chega é a de que o cinema foi ferramenta essencial de soft power dos EUA na América Latina e contribuiu para mudar a visão dos latino-americanos sobre os estadunidenses.
Solving Kryptos K4 — A Symbolic Decryption Using the Origami Framework
Creators: name: Cee, The
Publisher: name: Zenodo
Year: 2025

description: This record formally establishes the Origami Framework — a symbolic reasoning model for GPT-native AI, defined by a constraint → pattern → synthesis logic flow with F/I/P tagging (Fact / Inference / Interpretation). The formal declaration is available at: https://github.com/TheCee/origami-kryptos-solution/blob/main/ORIGAMI_FRAMEWORK.md

This method was used to generate the first known complete solution to Kryptos K4 using symbolic logic and native GPT capabilities only. The framework is licensed under Creative Commons Attribution 4.0 (CC BY 4.0) and timestamped through Zenodo, GitHub, and the Wayback Machine.

GitHub Repo: https://github.com/TheCee/origami-kryptos-solutionSHA-256: 0f6e03c0d8b24b1cfbe176ee6a86e442b1cb3ae4316461d9b48e49e7f56a73f3
Additional file 7 of TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
Creators: name: De Magis, Alessio
name: Schult, Philipp
name: Schönleber, Antonia
name: Linke, Rebecca
name: Ludwig, Kerstin U.
name: Kümmerer, Beate M.
name: Paeschke, Katrin
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 7. DNA oligonucleotides harboring the predicted G4 motifs within the exon 1 of the isoform 1 as well as all 4 sequences containing one of the selected SNP.
Genotype-environment interaction in maize hybrids: a multivariate relationship between yield components, morphological variables and disease tolerance
Creators: name: de Freitas Souza, Matheus
name: de Paiva Filho, Silvio Vasconcelos
name: Policarpo, Victor Hugo Custodio
name: Braz, Guilherme Braga Pereira
name: Simon, Gustavo André
name: do Carmo, Eduardo Lima
name: Solino, Antônio Jussiê
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology
subject: Virology

description: Knowledge of phenotypical variables, yield and susceptibility to diseases may clarify why some hybrids are more productive than others. In this study, we evaluated the stability and responsiveness of genotype-environment interactions on phenological variables, yield components and susceptibility to diseases of maize hybrids. Experiments were conducted in 5 regions in the Brazilian Midwest. Two population were used for each hybrid in each region, totalling 10 systems-environments. Data were analysed by Restricted Maximum Likelihood; Best Unbiased Linear Prediction and Principal Components Analysis. Environmental conditions and plant populations affect the yield components of maize hybrids. Variations equal to 57,000 and 62,700 plants ha−1 was relatively small and may not have been large enough to reveal plant density effects on disease. Diseases reduced the yield of hybrids with greater susceptibility to these phytopathogens at some sites, despite the use of fungicides. The best performance for at least two yield component variables resulted in the highest yield. Microclimate control using plant populations was omitted as a management option for reducing the severity and incidence of diseases for the tested conditions in this work. The climatic conditions of agricultural sites increased the incidence and severity of diseases, mainly of Cercospora zeae maydis.
Digital Pedagogy I: History, Theory, and Practice
Creators: name: Silva, Andie
Publisher: name: Humanities Commons
Year: 2022

description: This syllabus is designed to introduce masters students to the theory and practice of digital pedagogy, focusing on intersectional feminism as a core methodology. This course focuses particularly on the power of digital pedagogy and intersectional feminist praxis, aiming to centralize race, gender, class, and queer perspectives in academic debates. Readings in the course will focus on the history and development of the uses of technology in the classroom and academia alongside current attempts to critique how technology can reproduce structures of power and systems of oppression.
Supplemental Material, sj-docx-1-ear-10.1177_0145561320973772 - Granulomatous Inflammation Causing Severe Supraglottic Edema and Airway Obstruction in a Pediatric Patient
Creators: name: Colevas, Sophia M.
name: Gietman, Bradley T.
name: Cook, Shelly M.
name: Kille, Tony L.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110315 Otorhinolaryngology
subject: FOS: Clinical medicine

description: Supplemental Material, sj-docx-1-ear-10.1177_0145561320973772 for Granulomatous Inflammation Causing Severe Supraglottic Edema and Airway Obstruction in a Pediatric Patient by Sophia M. Colevas, Bradley T. Gietman, Shelly M. Cook and Tony L. Kille in Ear, Nose & Throat Journal
sj-pdf-1-vdi-10.1177_1040638720933875 – Supplemental material for Method comparison of targeted influenza A virus typing and whole-genome sequencing from respiratory specimens of companion animals
Creators: name: Mitchell, Patrick K.
name: Cronk, Brittany D.
name: Voorhees, Ian E. H.
name: Rothenheber, Derek
name: Anderson, Renee R.
name: Chan, Timothy H.
name: Wasik, Brian R.
name: Dubovi, Edward J.
name: Parrish, Colin R.
name: Goodman, Laura B.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine
subject: 70706 Veterinary Medicine
subject: FOS: Veterinary sciences

description: Supplemental material, sj-pdf-1-vdi-10.1177_1040638720933875 for Method comparison of targeted influenza A virus typing and whole-genome sequencing from respiratory specimens of companion animals by Patrick K. Mitchell, Brittany D. Cronk, Ian E. H. Voorhees, Derek Rothenheber, Renee R. Anderson, Timothy H. Chan, Brian R. Wasik, Edward J. Dubovi, Colin R. Parrish and Laura B. Goodman in Journal of Veterinary Diagnostic Investigation
Digital Pedagogy I: History, Theory, and Practice
Creators: name: Silva, Andie
Publisher: name: unknown
Year: 2022

description: This syllabus is designed to introduce masters students to the theory and practice of digital pedagogy, focusing on intersectional feminism as a core methodology. This course focuses particularly on the power of digital pedagogy and intersectional feminist praxis, aiming to centralize race, gender, class, and queer perspectives in academic debates. Readings in the course will focus on the history and development of the uses of technology in the classroom and academia alongside current attempts to critique how technology can reproduce structures of power and systems of oppression.
Solving Kryptos K4 — A Symbolic Decryption Using the Origami Framework
Creators: name: Cee, The
Publisher: name: Zenodo
Year: 2025

description: This record formally establishes the Origami Framework — a symbolic reasoning model for GPT-native AI, defined by a structured Constraint → Pattern → Synthesis logic flow, and enforced through F/I/P tagging (Fact, Inference, Interpretation).

The framework enables GPT to behave as a deterministic reasoning system, rather than a probabilistic text generator. It is the first documented architecture to demonstrate hallucination-free symbolic cognition using GPT-4 without plugins, APIs, or retrieval augmentation.

This method was used to generate the first known complete symbolic decryption of Kryptos K4, and is documented with cryptographic authorship (SHA-256), DOI, GitHub, and Wayback timestamps.

🔖 Formal declaration:ORIGAMI_FRAMEWORK.md

🧾 Project repository:https://github.com/TheCee/origami-kryptos-solution

🔐 Authorship SHA-256:0f6e03c0d8b24b1cfbe176ee6a86e442b1cb3ae4316461d9b48e49e7f56a73f3

🗂 This record includes:

CLAIM_OF_INVENTION.md: Signed, timestamped declaration

README.md, About_The_Author.md: Project and author metadata

Origami_Framework_Firsts.md: Verifiable AI research firsts

Kryptos_K4_Origami_WhitePaper.pdf: Full symbolic decryption paper

SHA256.txt: Authorship integrity hash

🧠 License: Creative Commons Attribution 4.0 (CC BY 4.0)
Additional file 8 of TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
Creators: name: De Magis, Alessio
name: Schult, Philipp
name: Schönleber, Antonia
name: Linke, Rebecca
name: Ludwig, Kerstin U.
name: Kümmerer, Beate M.
name: Paeschke, Katrin
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 8. SNPs in the exon 1 (5´UTR) of TMPRSS2 isoform 1 influence protein expression in HeLa cells. a) EtBr staining of the oligonucleotide harboring the G4 in the exon1 of the isoform 1 as well as oligonucleotide contained four SNPs that partially disrupt the G4 motifs obtained by NCBI. b) HeLa cells transfected with psiCHECK™-2 containing the G4 at exon 1 of TMPRSS2 gene and the four SNPs that partially disrupt the G4 motifs obtained by NCBI, cloned upstream of the reporter gene. Expression of psiCHECK™-2 was normalized to the G4_ Iso1.
Shuffling Softly, Sighing Deeply: A Digital Inquiry into Representations of Older Men and Women in Literature for Different Ages
Creators: name: Geybels, Lindsey
Publisher: name: Humanities Commons
Year: 2023
Subjects: subject: Digital humanities
subject: Ageism
subject: Older people
subject: Gender identity in literature

description: When gender is brought into concerns about older people, the emphasis often lies on stereotypes connected to older women, and few comparative studies have been conducted pertaining to the representation of the intersection between older age and gender in fiction. This article argues that not only children’s literature, traditionally considered to be a carrier of ideology, plays a large part in the target readership’s age socialization, but so do young adult and adult fiction. In a large corpus of 41 Dutch books written for different ages, the representation of older men and women is studied through the verbs, grammatical possessions and adjectives associated with the relevant fictional characters, which were extracted from the texts through the computational method of dependency parsing. Older adult characters featured most frequently in fiction for adults, where, more so than in the books for younger readers, they are depicted as being prone to illness, experiencing the effects of a deteriorating body and having a limited social network. In the books for children, little to no association between older adulthood and mortality was found in the data. Ageist stereotypes pertaining to both genders were found throughout the corpus. In terms of characterization, male older adults are associated more with physicality, including matters of illness and mobility, while character traits and emotions show up in a more varied manner in connection to female older characters.
Monitoring multiyear individual tree flowering and yield reveals high variation among ‘Pinkerton’ avocado trees
Creators: name: Rubinovich, Lior
name: Sofer-Arad, Carmit
name: Chernoivanov, Simon
name: Szenes, Nitzan
name: Noy, Michael
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology
subject: Virology

description: Most avocado cv. Pinkerton scions in Israel are grafted on seedling rootstocks, resulting in unstable yields. The objective of this study was to evaluate tree multiyear yield variation among ‘Pinkerton’ trees. We evaluated the flowering and yield variations among trees in two commercial avocado orchards, in Kibbutz Dan and Kibbutz Kfar-HaNassi, for 4 years. The multiyear average yield of the individual trees ranged from 9.5 to 73.7 kg tree−1 in Dan, and 1.7 to 53.8 kg tree−1 in Kfar-HaNassi, with coefficient of variation (CV) of 42% and 54%, respectively. Multiyear flowering intensity ranged from 2.7 to 4.9 and 2.41 to 5 (out of 5), with generally lower CV values of 14% and 26%, respectively. Multiyear alternate bearing index (ABI) ranged from 0.24 to 0.85 and 0.2 to 1, with CV of 25% and 32%, respectively. In Dan, the yield was negatively correlated with ABI. In Kfar-HaNassi, the yield was positively correlated with flowering intensity and negatively correlated with ABI. These results show that it may be important to monitor long-term individual tree yield, because removing low-yielding trees and selecting genetic material characterised by high yield and low ABI may be advantageous for establishing orchards with stable high yields.
Possessioner, a ‘cyberpink’ v-novel.
Creators: name: Akmut, Camille
Publisher: name: Humanities Commons
Year: 2023

description: another entry in the cyberpink (cyberpunk + queer) category or genre is presented here, in the form of the 1990s visual novel Possessioner - including many first time translations, complete staff list, characters, enemies and basic plot and mechanics. [older re-upload]
sj-pdf-1-cre-10.1177_0269215520976267 – Supplemental material for Speech and language therapy treatment on hypokinetic dysarthria in Parkinson disease: Systematic review and meta-analysis
Creators: name: Muñoz-Vigueras, Natalia
name: Prados-Román, Esther
name: Valenza, Marie Carmen
name: Granados-Santiago, Maria
name: Cabrera-Martos, Irene
name: Rodríguez-Torres, Janet
name: Torres-Sánchez, Irene
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 110314 Orthopaedics
subject: 110604 Sports Medicine
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-1-cre-10.1177_0269215520976267 for Speech and language therapy treatment on hypokinetic dysarthria in Parkinson disease: Systematic review and meta-analysis by Natalia Muñoz-Vigueras, Esther Prados-Román, Marie Carmen Valenza, Maria Granados-Santiago, Irene Cabrera-Martos, Janet Rodríguez-Torres and Irene Torres-Sánchez in Clinical Rehabilitation
Additional file 9 of TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
Creators: name: De Magis, Alessio
name: Schult, Philipp
name: Schönleber, Antonia
name: Linke, Rebecca
name: Ludwig, Kerstin U.
name: Kümmerer, Beate M.
name: Paeschke, Katrin
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 9. Original gels. a) original gels from Fig. 2e. b) original gel from Additional file 5.
Supplemental Material, CBSM_in_Theory_and_Practice___SMQ_supp._material_-_appendices - Community-Based Social Marketing in Theory and Practice: Five Case Studies of Water Efficiency Programs in Canada
Creators: name: Fries, Sarah
name: Cook, Julie
name: Lynes, Jennifer Kristin
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications
subject: 150402 Hospitality Management
subject: FOS: Economics and business

description: Supplemental Material, CBSM_in_Theory_and_Practice___SMQ_supp._material_-_appendices for Community-Based Social Marketing in Theory and Practice: Five Case Studies of Water Efficiency Programs in Canada by Sarah Fries, Julie Cook and Jennifer Kristin Lynes in Social Marketing Quarterly
title: Status review of Bryde's whales (Balaenoptera edeni) in the Gulf of Mexico under the Endangered Species Act
Creators: name: Rosel, Patricia E.
name: Corkeron, Peter
name: Engleby, Laura
name: Epperson, Deborah
name: Mullin, Keith D.
name: Soldevilla, Melissa S.
name: Taylor, Barbara L.
Publisher: name: U.S. Department of Commerce, National Oceanic and Atmospheric Administration, National Marine Fisheries Service, Southeast Fisheries Science Center
Year: 2016
Subjects: Bryde whale--Conservation--Mexico, Gulf of

description: This status review responds to a September 18, 2014 petition from the Natural Resources Defense Council to list the Gulf of Mexico (GOMx) population of Bryde's whale, Balaenoptera edeni, as an endangered distinct population segment (DPS) under the Endangered Species Act (ESA) and to designate critical habitat. Under the ESA, if a petition is found to present substantial scientific or commercial information indicating that the petitioned action may be warranted, a status review shall be commenced (16 U.S.C 1533 (b)(3)(A)). The National Marine Fisheries Service (NMFS) determined that the petition contained substantial scientific or commercial information indicating that the petitioned action may be warranted (80 FR 18343 2015), April 6, 2015). NMFS then requested from the public information on Bryde's whales in the GOMx including: (1) historical and current distribution, abundance, and population trends; (2) life history and biological information including adaptations to ecological settings, genetic information to assess paternal contribution and population connectivity, and movement patterns to determine population mixing; (3) management measures and regulatory mechanisms designed to protect the population; (4) any current or planned activities that may adversely impact them; and (5) ongoing or planned efforts to protect and restore the population and its habitat. The ESA stipulates listing determinations should be made on the basis of the best scientific and commercial information available. The agency convened a Status Review Team (SRT) comprised of experts in the fields of marine mammal biology and ecology, conservation biology, taxonomy, population dynamics, acoustics, and marine policy and GOMx management. The SRT reviewed all the available information, including that provided by the public, and then conducted a comprehensive evaluation of the Gulf of Mexico population of Bryde's whales that determines (1) whether the Gulf of Mexico population qualifies as a DPS, subspecies, or species; (2) summarizes the available information on the biology and threats to the population; (3) evaluates potentially significant threats to the population; and (4) assesses the extinction risk. This report describes the SRT's deliberations and conclusions. The draft status review was submitted to independent peer reviewers and comments and information received from them were addressed and incorporated as appropriate before finalizing the report.
Appendix_B_Studies_in_this_Review_and_their_Characteristics_GCQ – Supplemental material for Social–Emotional Characteristics and Adjustment of Accelerated University Students: A Systematic Review
Creators: name: Schuur, Jolande
name: Weerdenburg, Marjolijn Van
name: Hoogeveen, Lianne
name: Kroesbergen, Evelyn H.
Publisher: name: SAGE Journals
Year: 2020
Subjects: Education

description: Supplemental material, Appendix_B_Studies_in_this_Review_and_their_Characteristics_GCQ for Social–Emotional Characteristics and Adjustment of Accelerated University Students: A Systematic Review by Jolande Schuur, Marjolijn van Weerdenburg, Lianne Hoogeveen and Evelyn H. Kroesbergen in Gifted Child Quarterly
Supplemental Material, TJIA_PasT_AJHPM_ONLINE_SUPPLEMENT - Feasibility and Acceptability of Digital Legacy-Making: An Innovative Story-Telling Intervention for Adults With Cancer
Creators: name: DeSanto-Madeya, Susan
name: Tjia, Jennifer
name: Fitch, Christina
name: Wachholtz, Amy
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences
subject: 111702 Aged Health Care

description: Supplemental Material, TJIA_PasT_AJHPM_ONLINE_SUPPLEMENT for Feasibility and Acceptability of Digital Legacy-Making: An Innovative Story-Telling Intervention for Adults With Cancer by Susan DeSanto-Madeya, Jennifer Tjia, Christina Fitch and Amy Wachholtz in American Journal of Hospice and Palliative Medicine®
Impact of the Diagnosis-to-Treatment Interval on the Survival of Patients with Papillary Thyroid Cancer
Creators: name: Wei, Tingting
name: Huang, Hongbo
name: Zhang, Aijie
name: Zhang, Heng
name: Kong, Lingquan
name: Li, Yunhai
name: Li, Fan
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: For papillary thyroid cancer (PTC) patients, no consensus has been reached for the impact of diagnosis-to-treatment interval (DTI) on patient survival outcomes. We evaluated the impact of DTI on prognosis among patients with PTC. Patients diagnosed as PTC were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database between 2000 and 2019. The initial treatment strategies include surgery, radiation therapy, chemotherapy, hormone, immunotherapy, and/or active surveillance according to the SEER. Patients were grouped as follows: (I) DTI 0 (interval < 1 month or immediate treatment), (II) DTI 1–3 months, (III) DTI 4–5 months, and (IV) DTI ≥6 months. A total of 168,969 patients with PTC were included in this cohort study. Median follow-up time was 84.0 months. No significant overall survival (OS) difference was observed between patients with immediate treatment and DTI 1–3 months. However, DTI 4–5 months and ≥6 months were associated with poorer OS compared to patients with immediate treatment. Although Kaplan-Meier analysis suggested slight TCSS differences between the delayed and immediate treatment groups, these disappeared after adjusting for tumor characteristics and treatment factors. A short-term delay (1–3 months) had no significant impact on OS, whereas more than 3 months of DTI resulted in poorer OS. Notably, delayed treatment had no impact on TCSS. These findings suggest that short-term delays are unlikely to affect survival, supporting decision-making flexibility for patients with low-risk PTC within three months of diagnosis.