cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 2: of Targeted gene knockin in zebrafish using the 28S rDNA-specific non-LTR-retrotransposon R2Ol
Creators: name: Kuroki-Kami, Azusa
name: Narisu Nichuguti
name: Yatabe, Haruka
name: Mizuno, Sayaka
name: Kawamura, Shoji
name: Fujiwara, Haruhiko
Publisher: name: Figshare
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Table S1. Primer List. (PDF 195 kb)
Defining determinants of viral membrane protein immunogenicity
Creators: name: Faulkner, Nikhil Bruce
Publisher: name: Imperial College London
Year: 2022

description: Acquired immunity to the delivery vector for in vivo gene transfer or expression applications limits therapy efficacy upon repeat vector administration. However, a controlled comparison of vector immunogenicity, comparing immune responses to different viral vectors at comparable doses through the same delivery route, is yet to be carried out. In this thesis, antibody assays were used to study the humoral response to repeat dosing of lentiviral (LV) vectors of variable pseudotype (Sendai Virus Fusion protein/Hemagglutinin Neuraminidase protein and Vesicular Stomatitis Virus glycoprotein). The effects of antigen dose and delivery method were assessed. Through this, the envelope:gag ratio was identified as an important determinant for vector immunogenicity. Upon the emergence of SARS-CoV-2 in the United Kingdom in early 2020, the focus of this thesis shifted to studying the human antibody response to this pandemic virus. Antibody assays previously used to study anti-vector pseudotype antibodies to gene transfer vectors were used to study the kinetics and magnitude of antibody responses to SARS-CoV-2 variants. Interestingly, SARSCoV-2 Spike (S) S2 domain-specific IgG antibodies, derived from previous heterotypic human coronavirus (HCoV) infection, were identified in individuals uninfected and unexposed to SARS-CoV-2, and these S2-specific cross-reactive antibodies showed neutralising activity to SARS-CoV-2 S-pseudotyped LV vectors in vitro with comparable efficacy to sera from COVID-19 patients. Sera from patients infected with SARS-CoV-2 variants D614G or Alpha were able to recognise and neutralise homotypic and heterotypic variant S proteins with variable efficacy. Surprisingly, in some cases, a reduction in efficacy of binding and neutralisation occurred in a unidirectional and asymmetric pattern. Together, this thesis explores the many factors which determine antibody induction and duration, and suggests ways in which we can use this information to design better therapeutics involving LV gene transfer, such as gene therapy and vaccination.
The Impact of an Interprofessional Web-based Unfolding Case Study on the Knowledge, Skills, and Attitudes of Students via Online, Asynchronous Modules
Creators: name: Liebkemann, Sarah
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: The primary objectives were (1) to determine the impact of a web-based unfolding case study on the knowledge, skills, and attitudes of students in an online, interprofessional classroom and (2) to gain student feedback to modify and improve for future iterations. A web-based unfolding case study was delivered over a series of four modules. Learner outcomes were assessed through evaluation of forum activities and reflection papers. Post-module objective surveys, a debriefing session, and a post-course survey were utilized to collect feedback from the students in order to evaluate the unfolding case. Most respondents agreed that objectives were met in each of the four modules. Qualitative data provided information about knowledge, skills, and attitudes gained from the unfolding case, feedback for further development of the virtual reality prototype, and the impact that the start of the COVID-19 pandemic had on the implementation of the unfolding case.
On Convergence of Value Iteration for a Class of Total Cost Markov Decision Processes
Creators: name: Yu, Huizhen
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics
subject: 90C39, 90C40, 93E20

description: We consider a general class of total cost Markov decision processes (MDP) in which the one-stage costs can have arbitrary signs, but the sum of the negative parts of the one-stage costs is finite for all policies and all initial states. We refer to this class as the General Convergence (GC for short) total cost model, and we study the convergence of value iteration for the GC model, in the Borel MDP framework with universally measurable policies. Our main results include: (i) convergence of value iteration when starting from certain functions above the optimal cost function; (ii) convergence of transfinite value iteration starting from zero, in the special case where the optimal cost function is nonnegative; and (iii) partial convergence of value iteration starting from zero, for a subset of initial states. These results extend several previously known results about the convergence of value iteration for either positive costs problems or GC total cost problems. In particular, the first result on convergence of value iteration from above extends a theorem of van der Wal for the GC model. The second result relates to Maitra and Sudderth's analysis of transfinite value iteration for the positive costs model. It suggests connections between the two total cost models when the optimal cost function is nonnegative, and it leads to additional results on the convergence of ordinary non-transfinite value iteration, with a suitably defined dynamic programming operator, for finite state or finite control GC problems. The third result on partial convergence of value iteration is motivated by Whittle's bridging condition for the positive costs model, and provides a novel extension of the bridging condition to the GC model, where there are no sign constraints on the costs.
description: Revised report with corrections; 38 pages
Comparability and Representativeness of Control Groups in a Case-Control Study of Infant Leukemia: A Report From the Children's Oncology Group
Creators: name: Puumala, Susan E.
name: Linabery, Amy M.
name: Blair, Cindy K.
name: Roesler, Michelle A.
name: Bunin, Greta R.
name: Ross, Julie A.
name: Olshan, Andrew F.
name: Robison, Leslie L.
name: Spector, Logan G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Traditionally, controls in US pediatric cancer studies were selected through random digit dialing. With declining participation and lack of nonparticipant information, random digit dialing (RDD) controls may be substandard. Birth certificate (BC) controls are an alternative, because they are population based and include data from nonparticipants. The authors examined controls collected by random digit dialing and birth certificates for a Children's Oncology Group case-control study of infant leukemia in 1995–2006. Demographic variables were used to assess differences in RDD and BC controls and their representativeness. RDD and BC controls did not differ significantly with regard to maternal variables (age, race, education, marital status, alcohol during pregnancy) or child variables (sex, gestational age, birth weight), but they varied in smoking during pregnancy (22% RDD controls, 12% BC controls) (P = 0.05). The study's combined control group differed significantly from US births: Mothers of controls were more likely to be older (29.8 vs. 27.2 years), white (84% vs. 59%), and married (85% vs. 67%) and to have >16 years of education (37% vs. 25%). Control children were more often full term (88% vs. 81%) and heavier (3,436 vs. 3,317 g). Finally, participating BC mothers were likely to be older and to have more education than nonparticipants. Thus, the study's control groups were comparable but differed from the population of interest.
Competing Risk Regression Models for Epidemiologic Data
Creators: name: Gange, Stephen J.
name: Cole, Stephen R.
name: Lau, Bryan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Competing events can preclude the event of interest from occurring in epidemiologic data and can be analyzed by using extensions of survival analysis methods. In this paper, the authors outline 3 regression approaches for estimating 2 key quantities in competing risks analysis: the cause-specific relative hazard (csRH) and the subdistribution relative hazard (sdRH). They compare and contrast the structure of the risk sets and the interpretation of parameters obtained with these methods. They also demonstrate the use of these methods with data from the Women's Interagency HIV Study established in 1993, treating time to initiation of highly active antiretroviral therapy or to clinical disease progression as competing events. In our example, women with an injection drug use history were less likely than those without a history of injection drug use to initiate therapy prior to progression to acquired immunodeficiency syndrome or death by both measures of association (csRH = 0.67, 95% confidence interval: 0.57, 0.80 and sdRH = 0.60, 95% confidence interval: 0.50, 0.71). Moreover, the relative hazards for disease progression prior to treatment were elevated (csRH = 1.71, 95% confidence interval: 1.37, 2.13 and sdRH = 2.01, 95% confidence interval: 1.62, 2.51). Methods for competing risks should be used by epidemiologists, with the choice of method guided by the scientific question.
GERONTE Project: Development of a Framework to support implementation of Complex InterventiOns using Technology (CIo-uT): An Action Research study as part of multisite Randomised Controlled Trial
Creators: name: Sullivan, Bridget O
name: Staines, Professor Anthony
name: Dr. Paul Davis
name: Connolly, Professor Regina
name: Dr. Trudy Corrigan
name: White, Ciara
name: Hanlon, Shane O
Publisher: name: Zenodo
Year: 2022
Subjects: Implementation Science, Technology-supported healthcare, Complex interventions, care pathways, older adults, geriatric, oncology, patient -centred care, cancer care pathway, integrated care

description: This abstract and conference presentation outlined GERONTE's work in developing a novel framework to support the comprehensive and complex assessment needed when implementing complex and technology-supported interventions into healthcare. The GERONTE Complex InterventiOn using Technology (CLo-uT) will build on and synthesise across the relevant existing Implementation Science and Realist Research principles and ideas, and it will add key practical support and information identified from empirical analysis of implementation a complex technology-supported intervention in 16 diverse healthcare setting across 3 European countries as part of a large EU sponsored clinical trial. This framework, and its accompanying guides, will support the successful and sustained implementation of GERONTE intervention across diverse setting. This practical framework will also provide a guide to other clinicians and researcher as the use of complex and technology-supported intervention increases across many areas of healthcare.
Chemical Characterization of Isoprene- and Monoterpene-Derived SOA Tracers in Marine Aerosols from the Galápagos Islands
Creators: name: Szalkowski, Tessa
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: Atmospheric fine particulate matter plays a critical role in the global climate system and oceans are an important source. The Galápagos Islands present a pristine environment to investigate the sources of marine PM2.5. This study presents a month of meteorological data and real-time PM2.5 mass and discrete PM2.5 chemical measurements. PM2.5 samples collected onto high-volume quartz filters were chemically characterized using a hydrophilic interaction liquid chromatography method interfaced with electrospray ionization high-resolution quadrupole time-of-flight mass spectrometry (HILIC/ESI-HR-QTOFMS). PM2.5 organic constituents showed a medium correlation with both marine and terrestrial tracers. The data also shows, for the first time, evidence of isoprene- and monoterpene-derived SOA on the Galápagos Islands. Approximately 3% of the total particulate organic carbon (OC) on the filters was quantified. Our work demonstrates the feasibility for the Galápagos Islands as a location for collection and speciation of marine aerosols. However, future work should address larger sources of OC.
Entanglement swapping between discrete and continuous variables
Creators: name: Takeda, Shuntaro
name: Fuwa, Maria
name: van Loock, Peter
name: Furusawa, Akira
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We experimentally realize "hybrid" entanglement swapping between discrete-variable (DV) and continuous-variable (CV) optical systems. DV two-mode entanglement as obtainable from a single photon split at a beam splitter is robustly transferred by means of efficient CV entanglement and operations, using sources of squeezed light and homodyne detections. The DV entanglement after the swapping is verified without post-selection by the logarithmic negativity of up to 0.28$\pm$0.01. Furthermore, our analysis shows that the optimally transferred state can be post-selected into a highly entangled state that violates a Clauser-Horne-Shimony-Holt inequality by more than four standard deviations, and thus it may serve as resources for quantum teleportation and quantum cryptography.
Additional file 12: of Effects of a health education intervention on hypertension-related knowledge, prevention and self-care practices in Nigerian retirees: a quasi-experimental study
Creators: name: Eyuche Ozoemena
name: Cylia Iweama
name: Olaoluwa Agbaje
name: Umoke, Prince
name: Osmond Ene
name: Ofili, Perpetua
name: Agu, Benedicta
name: Orisa, Charity
name: Agu, Michael
name: Enejoh Anthony
Publisher: name: Figshare
Year: 2019
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Results of paired samples T-tests. (DOCX 20 kb)
Impact of the initial size of spatial fluctuations on the collective flow in Pb-Pb collisions at $\sqrt{s_{NN}}$ = 2.76 TeV
Creators: name: Konchakovski, V. P.
name: Cassing, W.
name: Toneev, V. D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The Parton-Hadron-String-Dynamics (PHSD) transport model is used to study the influence of the initial size of spatial fluctuations of the interacting system on flow observables in Pb-Pb collisions at $\sqrt{s_{NN}}$ = 2.76 TeV for different centralities. While the flow coefficients $v_2$, $v_3$, $v_4$ and $v_5$ are reasonably described in comparison to the data from the ALICE Collaboration for different centralities within the default setting, no essential sensitivity is found with respect to the initial size of spatial fluctuations even for very central collisions where the flow coefficients are dominated by the size of initial state fluctuations. We attribute this lack of sensitivity partly to the low interaction rate of the degrees-of-freedom in this very early phase of order $\sim$ 0.3 fm/c which is also in common with the weakly interacting color glass condensate (CGC) or glasma approach. Moreover, since the event shape in the transverse plane is approximately the same for different size of spatial fluctuations very similar eccentricities $ε_n$ are transformed to roughly the same flow coefficients $v_n$ in momentum space.
description: 15 pages, 8 figures. arXiv admin note: text overlap with arXiv:1401.4409
Potential and challenges of high-speed (4D) body scanning for mobility analysis of firefighter clothing - a methodical case study
Creators: name: Muenks, Dominik
name: Kyosev, Yordan
name: Kunzelmann, Felix
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2023
Subjects: highspeed body scanning
motion comfort
automated analysis
protective clothing
firefighter clothing
4D-scanning

description: In this study, protective clothing for firefighters is analyzed using 4D body scanning and 3D hand scanning, with a focus on the experimental analysis of ergonomic comfort. In particular, German firefighting clothing is examined to discuss the possibilities and limitations of current scanning technologies for capturing firefighting clothing. For this purpose, various movements are recorded in the 4D scanner. In addition, a method for determining position changes of protective clothing at identified limits is presented. The initial results illustrated that the analysis of protective clothing for firefighters using 4D scanning is problematic due to specific materials, reflections, and surface properties. Improvements in the scanning process and optimization of algorithms are required to achieve more detailed and precise results. Concerning the ergonomic comfort related to the mobility under firefighting clothing use conditions, this methodical case study highlights the limits of current approaches, with a focus on the limitations of 4D scanning and potential improvements.
description: EXCLI Journal; 22:Doc1092; ISSN 1611-2156
3D UNet Arabidopsis Ovules Nuclei
Creators: name: Yu, Qin
name: Wolny, Adrian
Publisher: name: Zenodo
Year: 2023
Subjects: bioimage.io
bioimage.io:model
nuclei-segmentation
plantseg
unet
3d
semantic-segmentation
arabidopsis
ovules
plant
confocal-microscopy
pytorch

description: Download RDF Package
3D UNet Arabidopsis Ovules Nuclei Unet trained on confocal images of Arabidopsis Ovules nuclei stain with BCEDiceLoss. Voxel size: [0.35, 0.1, 0.1] µm^3. The network predicts 1 channel: nuclei probability maps and expects the input to be of size [N, 1, Z, Y, X]
description: UNet trained on confocal images of Arabidopsis Ovules nuclei. Voxel size: [0.35, 0.1, 0.1] (Uploaded via https://bioimage.io)
What platforms and editors need. Interviews for CRAFT-OA
Creators: name: Verdicchio, Dirk
name: Pellin, Elio
Publisher: name: Zenodo
Year: 2023

description: The CRAFT-OA project (Creating a Robust Accessible Federated Technology for Open Access) will improve the conditions for publishing OA diamond journals. CRAFT-OA's 23 consortium partners from 14 European countries are all engaged in institutional publishing and its infrastructures, and committed to sustaining and developing capacities in the field. Within 36 months, CRAFT-OA will deliver technical and community tools, training events, training materials, information, and services for the Diamond OA institutional publishing environment. It will foster communities of practice with the capacity to sustain the project improvements over time.
Within the framework of EU project CRAFT-OA, we are conducting 10 semistructured interviews with institutional platform service providers and with editors of scientific journals all over Europe. The interviews are a supplement to the quantitative DIAMAS survey. They are designed as guided interviews, so that detailed answers and clarifications are possible. The content covers topics such as hosting, submissions and reviews, production, metrics, indexing, archiving, finance, and quality management.
The non-representative interviews offer in-depth insights into the needs of editors and platform service providers. The thematic evaluation of the interview will allow us to bring the concrete needs and problems of the editors and platform operators into the CRAFT-OA project to improve the conditions for publishing OA diamond journals.
Effect of Highly Active Antiretroviral Therapy on Incident AIDS Using Calendar Period as an Instrumental Variable
Creators: name: Chmiel, Joan S.
name: Greenland, Sander
name: Cain, Lauren E.
name: Brown, Todd T.
name: Cole, Stephen R.
name: Kingsley, Lawrence
name: Detels, Roger
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Human immunodeficiency virus (HIV) researchers often use calendar periods as an imperfect proxy for highly active antiretroviral therapy (HAART) when estimating the effect of HAART on HIV disease progression. The authors report on 614 HIV-positive homosexual men followed from 1984 to 2007 in 4 US cities. During 5,321 person-years, 268 of 614 men incurred acquired immunodeficiency syndrome, 49 died, and 90 were lost to follow-up. Comparing the pre-HAART calendar period (<1996) with the HAART calendar period (≥1996) resulted in a naive rate ratio of 3.62 (95% confidence limits: 2.67, 4.92). However, this estimate is likely biased because of misclassification of HAART use by calendar period. Simple calendar period approaches may circumvent confounding by indication at the cost of inducing exposure misclassification. To correct this misclassification, the authors propose an instrumental-variable estimator analogous to ones previously used for noncompliance corrections in randomized clinical trials. When the pre-HAART calendar period was compared with the HAART calendar period, the instrumental-variable rate ratio was 5.02 (95% confidence limits: 3.45, 7.31), 39% higher than the naive result. Weighting by the inverse probability of calendar period given age at seroconversion, race/ethnicity, and time since seroconversion did not appreciably alter the results. These methods may help resolve discrepancies between observational and randomized evidence.
Genome-Wide Association Studies, Field Synopses, and the Development of the Knowledge Base on Genetic Variation and Human Diseases
Creators: name: Dolan, Siobhan M.
name: Pagon, Roberta A.
name: Ostell, James
name: Little, Julian
name: Gwinn, Marta
name: Chockalingam, Anand
name: Furberg, Helena
name: Fortier, Isabel
name: O'Brien, Thomas R.
name: Bernstein, Jonine L.
name: Owen, Ryan P.
name: Ioannidis, John P.A.
name: Boffetta, Paolo
name: Yu, Wei
name: Garcia-Closas, Montserrat
name: Higgins, Julian P.T.
name: Khoury, Muin J.
name: Vineis, Paolo
name: Winn, Deborah M.
name: Rothman, Nathaniel
name: Chanock, Stephen J.
name: Burton, Paul R.
name: Rebbeck, Timothy R.
name: Janssens, A. Cecile J.W.
name: Bertram, Lars
name: Campbell, Harry
name: Butterworth, Adam S.
name: Seminara, Daniela
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Genome-wide association studies (GWAS) have led to a rapid increase in available data on common genetic variants and phenotypes and numerous discoveries of new loci associated with susceptibility to common complex diseases. Integrating the evidence from GWAS and candidate gene studies depends on concerted efforts in data production, online publication, database development, and continuously updated data synthesis. Here the authors summarize current experience and challenges on these fronts, which were discussed at a 2008 multidisciplinary workshop sponsored by the Human Genome Epidemiology Network. Comprehensive field synopses that integrate many reported gene-disease associations have been systematically developed for several fields, including Alzheimer's disease, schizophrenia, bladder cancer, coronary heart disease, preterm birth, and DNA repair genes in various cancers. The authors summarize insights from these field synopses and discuss remaining unresolved issues—especially in the light of evidence from GWAS, for which they summarize empirical P-value and effect-size data on 223 discovered associations for binary outcomes (142 with P < 10−7). They also present a vision of collaboration that builds reliable cumulative evidence for genetic associations with common complex diseases and a transparent, distributed, authoritative knowledge base on genetic variation and human health. As a next step in the evolution of Human Genome Epidemiology reviews, the authors invite investigators to submit field synopses for possible publication in the American Journal of Epidemiology.
3D UNet Arabidopsis Ovules Nuclei
Creators: name: Yu, Qin
name: Wolny, Adrian
Publisher: name: Zenodo
Year: 2023
Subjects: bioimage.io
bioimage.io:model
nuclei-segmentation
plantseg
unet
3d
semantic-segmentation
arabidopsis
ovules
plant
confocal-microscopy
pytorch

description: Download RDF Package 3D UNet Arabidopsis Ovules Nuclei Unet trained on confocal images of Arabidopsis Ovules nuclei stain with BCEDiceLoss. Voxel size: [0.35, 0.1, 0.1] µm^3. The network predicts 1 channel: nuclei probability maps and expects the input to be of size [N, 1, Z, Y, X]
description: UNet trained on confocal images of Arabidopsis Ovules nuclei. Voxel size: [0.35, 0.1, 0.1] (Uploaded via https://bioimage.io)
THE RELATIONSHIP BETWEEN RACIAL AND ETHNIC IDENTITY AND CONCUSSION CARE SEEKING BEHAVIORS
Creators: name: Cosby Jr., Anthony
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: Concussions are prevalent and underreported in youth and adolescent athletes.  This study utilized a multi-methods design to include analysis of survey data (Aims 1 and 2), and semi-structured interviews (Aim 3) to examine the association between racial identity and concussion care seeking behaviors and to better understand how racial identity relates to these behaviors. Data for aims 1 and 2 were collected as a part of a larger study. Aim 3 data was collected via virtual interviews during the 2020-2021 academic year. When collapsing racial identification categories (identifying as a race other than white or white), a higher prevalence of respondents identifying as a race other than white indicated witnessing a teammate report another teammate’s concussion symptoms (PR=1.34; 95% CI: 1.02, 1.78). Semi-structured, guided interviews highlighted the complexities of identity and concussion care seeking behaviors including three key themes: sport safety, identity, and disclosure/care seeking.
Plan estratégico sobre Recursos Fitogeneticos in Uruguay
Creators: name: Comité Nacional sobre los Recursos Fitogenéticos
Publisher: name: ITPGRFA
Year: 2024
Subjects: ITPGRFA-BSF
National Plan of Action
In situ conservation
Ex situ conservation
URY
Family farming
PR-177
National strategy
On-farm conservation
Sustainable agriculture
Policy

description: This presentation presents the meian elements of a proposal made by  National Committee on Plant Genetic Resources in Uruguay to a network of organization (CNFR, INASE, INIA, MA, MGAP, MRREE, RAU, RNSyC, UDELAR, UDELAR, etc.) to update the national Plan by sharing and enriching the existing proposal of the Strategic Plan Strategic Plan, engage to secure commitment and support for the development and implementation of the Strategic Plan etc. 

The presentation provides a context of the development of the Strategic Action Plan and gives some historic background to the main steps the led to its realization. It also puts the focus on the priority areas of intervention in terms of PGRFA and illustrates the main needs also the different conservation efforts: In situ, on farm ex situ.  needs in terms of conservation and sustainable use of plant genetic resources. 

The project  " Articulación nacional para la gobernanza y gestión de colectiva de la diversidad genética y sus conocimientos asociados en la agricultura familiar y campesina del Uruguay:  funded in the 4th call for Proposals of the Benefit Sharing Fund (BSF) of the International Treaty of Plant Genetic Resources for Food and Agriculture (ITPGRFA) of the Food and Agriculture Organization (FAO), gave during the Tenth Session of the Governing Body of ITPGRFA contributed to the discussions and need to have a clear implementation and follow up of the plan
PROBING THE DEGRADABILITY OF METHYL-LYSINE READER PROTEINS USING HETEROBIFUNCTIONAL MOLECULES
Creators: name: Guzman Rodriguez, Kenneth Benjamin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: Methyl-lysine reader (Kme) proteins recognize post-translational modifications, specifically methyl marks, on histone tails and recruit other chromatin interacting proteins that participate in transcription regulation. However, dysregulation of Kme reader proteins have been linked to a multitude of cancers, and efforts to develop potent and selective inhibitors for many Kme reader proteins to understand their function in disease is an important endeavor. There are many Kme reader proteins that still do not have high quality chemical probes to study their function. This can be attributed to many factors, mainly to the shallow binding pocket of Kme reader proteins that makes it difficult for potential inhibitors to bind to the pocket. Here we report an alternative strategy to the small molecule approach by using heterobifunctional molecules to potentially degrade Kme reader proteins. This thesis describes the efforts to develop heterobifunctional degraders for the largely unexplored Kme reader proteins.
Treatment Effects in the Presence of Unmeasured Confounding: Dealing With Observations in the Tails of the Propensity Score Distribution--A Simulation Study
Creators: name: Glynn, Robert J.
name: Avorn, Jerry
name: Stürmer, Til
name: Rothman, Kenneth J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Frailty, a poorly measured confounder in older patients, can promote treatment in some situations and discourage it in others. This can create unmeasured confounding and lead to nonuniform treatment effects over the propensity score (PS). The authors compared bias and mean squared error for various PS implementations under PS trimming, thereby excluding persons treated contrary to prediction. Cohort studies were simulated with a binary treatment T as a function of 8 covariates X. Two of the covariates were assumed to be unmeasured strong risk factors for the outcome and present in persons treated contrary to prediction. The outcome Y was simulated as a Poisson function of T and all X’s. In analyses based on measured covariates only, the range of PS's was trimmed asymmetrically according to the percentile of PS in treated patients at the lower end and in untreated patients at the upper end. PS trimming reduced bias due to unmeasured confounders and mean squared error in most scenarios assessed. Treatment effect estimates based on PS range restrictions do not correspond to a causal parameter but may be less biased by such unmeasured confounding. Increasing validity based on PS trimming may be a unique advantage of PS's over conventional outcome models.
Alternative Methods of Accounting for Underreporting and Overreporting When Measuring Dietary Intake-Obesity Relations
Creators: name: Mendez, Michelle A.
name: Sánchez, María José
name: Amiano, Pilar
name: Huerta, José María
name: Buckland, Genevieve
name: Barricarte, Aurelio
name: Quirós, José R.
name: Schroder, Helmut
name: Popkin, Barry M.
name: González, Carlos A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Misreporting characterized by the reporting of implausible energy intakes may undermine the valid estimation of diet-disease relations, but the methods to best identify and account for misreporting are unknown. The present study compared how alternate approaches affected associations between selected dietary factors and body mass index (BMI) by using data from the European Prospective Investigation Into Cancer and Nutrition-Spain. A total of 24,332 women and 15,061 men 29–65 years of age recruited from 1992 to 1996 for whom measured height and weight and validated diet history data were available were included. Misreporters were identified on the basis of disparities between reported energy intakes and estimated requirements calculated using the original Goldberg method and 2 alternatives: one that substituted basal metabolic rate equations that are more valid at higher BMIs and another that used doubly labeled water-predicted total energy expenditure equations. Compared with results obtained using the original method, underreporting was considerably lower and overreporting higher with alternative methods, which were highly concordant. Accounting for misreporters with all methods yielded diet-BMI relations that were more consistent with expectations; alternative methods often strengthened associations. For example, among women, multivariable-adjusted differences in BMI for the highest versus lowest vegetable intake tertile (β = 0.37 (standard error, 0.07)) were neutral after adjusting with the original method (β = 0.01 (standard error, 07)) and negative using the predicted total energy expenditure method with stringent cutoffs (β = −0.15 (standard error, 0.07)). Alternative methods may yield more valid associations between diet and obesity-related outcomes.
Impact of Breastfeeding Duration on Age at Menarche
Creators: name: Hamadeh, Mazen J.
name: Tamim, Hala
name: Al-Sahab, Ban
name: Ardern, Chris I.
name: Adair, Linda
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The study aims to assess the relation between breastfeeding duration and age at menarche. Analysis was based on a cohort of 994 Filipino girls born in 1983–1984 and followed up from infancy to adulthood by the Cebu Longitudinal Health and Nutrition Survey. The main outcome was self-reported age at menarche. Cox regression was used to investigate the relation between duration of exclusive and any breastfeeding with age at menarche with adjustment sequentially for specific sets of known socioeconomic, maternal, genetic, and prenatal confounders. The estimated median of age at menarche was 13.08 years. After adjustment for potential confounders of the association of breastfeeding with age at menarche, exclusive breastfeeding duration retained an independent and significant association with age at menarche. An increase in 1 month of exclusive breastfeeding decreases the hazard of attaining earlier menarche by 6% (hazard ratio = 0.94, 95% confidence interval: 0.90, 0.98). Any breastfeeding duration was not associated with age at menarche. Although this is the first longitudinal study that reveals a negative association between exclusive breastfeeding and early menarche, the relation is still elusive. Further longitudinal studies within different contexts are warranted to assess the generalizability of these findings.
3D UNet Arabidopsis Ovules Nuclei
Creators: name: Yu, Qin
name: Wolny, Adrian
Publisher: name: Zenodo
Year: 2023
Subjects: bioimage.io
bioimage.io:model
nuclei-segmentation
plantseg
unet
3d
semantic-segmentation
arabidopsis
ovules
plant
confocal-microscopy
pytorch

description: Download RDF Package
3D UNet Arabidopsis Ovules Nuclei Unet trained on confocal images of Arabidopsis Ovules nuclei stain with BCEDiceLoss. Voxel size: [0.35, 0.1, 0.1] µm^3. The network predicts 1 channel: nuclei probability maps and expects the input to be of size [N, 1, Z, Y, X]
description: Unet trained on confocal images of Arabidopsis Ovules nuclei (Uploaded via https://bioimage.io)
Contexts of Contestation: When do Policy, Enforcement, and Citizenship Shape Immigrant Political Participation?
Creators: name: Vo, Austin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: Immigrants experience very different political contexts in the United States depending on the mixture of policies and enforcement practices they encounter. I examine how formal citizenship shapes political participation and analyze this across race and state immigration context. I investigate how immigration federalism and the devolution of legal control impact political participation. I find that citizens participate more than noncitizens, and Latin Americans more than Asians, but both effects are moderated by state immigration contexts. For those in states with more inclusive policy, formal citizenship becomes less salient for participation while further enabling participation among Latin Americans. However, greater enforcement has a chilling effect on participation for Latinos but not Asians thereby working to dampen the boost in participation that Latinos have compared to Asians. I contend that inclusive policy and decreased enforcement are mechanisms by which civic stratification along race and citizenship can be mitigated to further immigrant incorporation and democratization.
Valley Zeeman effect and spin-valley polarized conductance in monolayer MoS$_2$ in a perpendicular magnetic field
Creators: name: Rostami, Habib
name: Asgari, Reza
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We study the effect of a perpendicular magnetic field on the electronic structure and charge transport of a monolayer MoS$_2$ nanoribbon at zero temperature. We particularly explore the induced valley Zeeman effect through the coupling between the magnetic field, $B$, and the orbital magnetic moment. We show that the effective two-band Hamiltonian provides a mismatch between the valley Zeeman coupling in the conduction and valence bands due to the effective mass asymmetry and it is proportional to $B^2$ similar to the diamagnetic shift of exciton binding energies. However, the dominant term which evolves with $B$ linearly, originates from the multi-orbital and multi-band structures of the system. Besides, we investigate the transport properties of the system by calculating the spin-valley resolved conductance and show that, in a low-hole doped case, the transport channels at the edge are chiral for one of the spin components. This leads to a localization of the non-chiral spin component in the presence of disorder and thus provides a spin-valley polarized transport induced by disorder.
description: 12 pages, 7 figures, new references are added
Impulsvortrag zu ORCID - PID für Personen
Creators: name: Marín-Arraiza, Paloma
Publisher: name: Zenodo
Year: 2023
Subjects: ORCID
Persistent Identifiers

description: 7-minütiger Impulsvortrag zu ORCID im Rahmen des Online-Seminares "PID für Personen" des Projekts PID-Network Deutschland am 19. Oktober 2023.
Local inverse scattering at a fixed energy for radial Schr{ö}dinger operators and localization of the Regge poles
Creators: name: Daudé, Thierry
name: Nicoleau, Francois
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We study inverse scattering problems at a fixed energy for radial Schrödinger operators on $\R^n$, $n \geq 2$. First, we consider the class $\mathcal{A}$ of potentials $q(r)$ which can be extended analytically in $\Re z \geq 0$ such that $\mid q(z)\mid \leq C \ (1+ \mid z \mid )^{-ρ}$, $ρ\textgreater{} \frac{3}{2}$. If $q$ and $\tilde{q}$ are two such potentials and if the corresponding phase shifts $δ\_l$ and $\tildeδ\_l$ are super-exponentially close, then $q=\tilde{q}$. Secondly, we study the class of potentials $q(r)$ which can be split into $q(r)=q\_1(r) + q\_2(r)$ such that $q\_1(r)$ has compact support and $q\_2 (r) \in \mathcal{A}$. If $q$ and $\tilde{q}$ are two such potentials, we show that for any fixed $a\textgreater{}0$, ${\ds{δ\_l - \tildeδ\_l \ = \ o \left( \frac{1}{l^{n-3}} \ \left( {\frac{ae}{2l}}\right)^{2l}\right)}}$ when $l \rightarrow +\infty$ if and only if $q(r)=\tilde{q}(r)$ for almost all $r \geq a$. The proofs are close in spirit with the celebrated Borg-Marchenko uniqueness theorem, and rely heavily on the localization of the Regge poles that could be defined as the resonances in the complexified angular momentum plane. We show that for a non-zero super-exponentially decreasing potential, the number of Regge poles is always infinite and moreover, the Regge poles are not contained in any vertical strip in the right-half plane. For potentials with compact support, we are able to give explicitly their asymptotics. At last, for potentials which can be extended analytically in $\Re z \geq 0$ with $\mid q(z)\mid \leq C \ (1+ \mid z \mid )^{-ρ}$, $ρ\textgreater{}1$ , we show that the Regge poles are confined in a vertical strip in the complex plane.
description: 52 pages
Additional file 1: of Predictors of traumatic birth experience among a group of Iranian primipara women: a cross sectional study
Creators: name: Ghanbari-Homayi, Solmaz
name: Fardiazar, Zahra
name: Meedya, Shahla
name: Mohammad-Alizadeh-Charandabi, Sakineh
name: Asghari-Jafarabadi, Mohammad
name: Eesa Mohammadi
name: Mirghafourvand, Mojgan
Publisher: name: figshare
Year: 2019
Subjects: subject: Cell Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology

description: The Childbirth Experience Questionnaire â€“ CEQ 2.0. (DOCX 112 kb)
Kreativität – klar? Was Lehrpersonen über Kreativität wissen
Creators: name: Bütler, Melanie
Publisher: name: Zenodo
Year: 2023
Subjects: Sonderpädagogik
Masterarbeit
Kreativität
Schule
Lehrperson

description: Kreativität ist ein wichtiger Bestandteil heutiger Bildungsziele. In dieser Arbeit wird der Frage nachgegangen, was Lehrpersonen über das Konstrukt Kreativität wissen. Mittels eines Fragebogens werden Daten erhoben zu den Bereichen: Theoriewissen, Einschätzung der Relevanz des Themas und Einschätzung der persönlichen Kreativität. Die Ergebnisse zeigen: Die Lehrpersonen verfügen meist über ein unspezifisches Theoriewissen, schätzen aber ihre eigene Kreativität und die Relevanz des Themas als hoch ein. Auf die Ergebnisse hat weder das Alter der Person, ihre Berufserfahrung noch die Unterrichtstufe oder Funktion, in welcher sie unterrichtet, einen Einfluss. Die Mehrheit der befragten Lehrpersonen möchte ihr Wissen über Kreativität vergrössern. Die Erkenntnisse dieser Studie bilden gute Grundlagen für die Weiterarbeit mit dem Thema Kreativität in der Schule. Ein nächster Schritt könnte die Entwicklung eines Fortbildungsmoduls über Wissen und Umsetzungsmöglichkeiten von Kreativität in der Schule für Lehrpersonen sein.
Missing Data on the Estimation of the Prevalence of Accumulated Human Immunodeficiency Virus Drug Resistance in Patients Treated With Antiretroviral Drugs in North America
Creators: name: Jacobson, Lisa
name: Gange, Stephen J.
name: Rourke, Sean
name: Klein, Marina
name: Horberg, Michael
name: Sterling, Timothy
name: Mckaig, Rosemary
name: Bosch, Ron
name: Hogg, Robert
name: Gill, M. John
name: Eron, Joseph
name: Willig, James
name: Kitahata, Mari
name: Justice, Amy
name: Lau, Bryan
name: Silverberg, Michael
name: Kirk, Greg
name: Thorne, Jennifer
name: Benson, Constance
name: Goedert, James
name: Rachlis, Anita
name: Martin, Jeff
name: Napravnik, Sonia
name: Zhang, Jinbing
name: Abraham, Alison G.
name: Collier, Ann
name: Moore, Richard D.
name: Gebo, Kelly
name: Deeks, Steven
name: Rodriguez, Benigno
name: Harrigan, Richard
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Determination of the prevalence of accumulated antiretroviral drug resistance among persons infected with human immunodeficiency virus (HIV) is complicated by the lack of routine measurement in clinical care. By using data from 8 clinic-based cohorts from the North American AIDS Cohort Collaboration on Research and Design, drug-resistance mutations from those with genotype tests were determined and scored using the Genotypic Resistance Interpretation Algorithm developed at Stanford University. For each year from 2000 through 2005, the prevalence was calculated using data from the tested subset, assumptions that incorporated clinical knowledge, and multiple imputation methods to yield a complete data set. A total of 9,289 patients contributed data to the analysis; 3,959 had at least 1 viral load above 1,000 copies/mL, of whom 2,962 (75%) had undergone at least 1 genotype test. Using these methods, the authors estimated that the prevalence of accumulated resistance to 2 or more antiretroviral drug classes had increased from 14% in 2000 to 17% in 2005 (P < 0.001). In contrast, the prevalence of resistance in the tested subset declined from 57% to 36% for 2 or more classes. The authors’ use of clinical knowledge and multiple imputation methods revealed trends in HIV drug resistance among patients in care that were markedly different from those observed using only data from patients who had undergone genotype tests.
Matching the Nagy-Soper parton shower at next-to-leading order
Creators: name: Czakon, M.
name: Hartanto, H. B.
name: Kraus, M.
name: Worek, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present an MC@NLO-like matching of next-to-leading order QCD calculations with the Nagy-Soper parton shower. An implementation of the algorithm within the HELAC-DIPOLES Monte Carlo generator is used to address the uncertainties and ambiguities of the matching scheme. First results obtained using the Nagy-Soper parton shower implementation in DEDUCTOR in conjunction with the HELAC-NLO framework are given for the pp -> top anti-top j + X process at the LHC with sqrt(s)=8 TeV. Effects of resummation are discussed for various observables.
description: 53 pages, 18 figures, 3 tables. References and a few typos corrected, acknowledgments added, dependence on the variation of the starting shower time corrected, version to appear in JHEP
Development of an Implementation Framework to evaluate individual and collective components of Complex Intervention using Technology (CL-uT): An Action Research study as part of a multisite Randomised Controlled Trial.
Creators: name: Sullivan, Bridget O
Publisher: name: Zenodo
Year: 2022
Subjects: Implementation Science, Technology-supported healthcare, Complex interventions, care pathways, older adults, geriatric, oncology, patient -centred care, cancer care pathway, integrated care

description: This abstract and conference presentation outlined GERONTE's work in developing a novel framework to support the comprehensive and complex assessment needed when implementing complex and technology-supported interventions into healthcare. The GERONTE Complex Intervention using Technology (CL-uT or CLOUT) will build on and synthesise across the relevant existing Implementation Science and Realist Research principles and ideas, and it will add key practical support and information identified from empirical analysis of implementation a complex technology-supported intervention in 16 diverse healthcare setting across 3 European countries as part of a large EU sponsored clinical trial. This framework, and its accompanying guides, will support the successful and sustained implementation of GERONTE intervention across diverse setting. This practical framework will also provide a guide to other clinicians and researcher as the use of complex and technology-supported intervention increases across many areas of healthcare.
Hysteresis and metastability of Bose-Einstein condensed clouds of atoms confined in ring potentials
Creators: name: Roussou, A.
name: Tsibidis, G. D.
name: Smyrnakis, J.
name: Magiropoulos, M.
name: Efremidis, Nikolaos K.
name: Jackson, A. D.
name: Kavoulakis, G. M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We consider a Bose-Einstein condensed cloud of atoms which rotate in a toroidal/annular potential. Assuming one-dimensional motion, we evaluate the critical frequencies associated with the effect of hysteresis and the critical coupling for stability of the persistent currents. We perform these calculations using both the mean-field approximation and the method of numerical diagonalization of the many-body Hamiltonian which includes corrections due to the finiteness of the atom number.
description: 7 pages, 5 figures, section on experimental relevance added, final version