cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
LEARNING OPTIMIZING TECHNIQUES FOR LOGISTICS AND INVENTORY MANAGEMENT
Creators: name: Personal Improvement Computer Systems
Publisher: name: Zenodo
Year: 2024

description: Given that the face of supply chains is constantly rapidly, then the use of ML may potentially create quite several opportunities within this flexible and sustainable realm. This research aims to understand how numerous algorithms within the areas of artificial intelligence particularly, the subfield of machine learning enhance the supply chain together with its inventory systems and flow. For instance, Ridge Regression, Lasso Regression, Elastic Net Regression, Gradient Boosted Trees and K-means Clustering, DBSCAN, and CNNs were designed specifically to solve problems in those fields. The use of both Ridge Regression and Lasso Regression allowed for the accurate improvement of the inventory forecast which in turn decreased forecast error of inventories by 20% and the number of times inventory was turned over by 15%. With the help of GBTs and CNNs the delivery routes were optimized and it contributed to the reduction of the transportation costs by 30% and the delivery time by 25%. By using K-means and DBSCAN, it was easier to sort the inventories and manage risks; which led to an improvement of the inventory turnover ratio by 15 percent and the level of addressing the unanticipated by 18 percent. In addition, the addition of external stimuli, for instance, traffic flow and trending topics on social media boosted the models and defined the differentiation of their decision-making values. They are presumably the sign that with machine learning it is possible to build better, efficient, relevant supply networks. This research sits well with the current literature on the application of ML to the field of supply chain management and offers some practical and useful insights to managers on how to best deploy these techniques for higher organizational value.
title: Across the Atlantic: Searching for the origins of disease tolerance in three Myotis bats
Creators: name: Whiting-Fawcett, Flora
Publisher: name: University of Liverpool Repository
Year: 2024

description: As the climate warms and human movement increases, the incidence of pathogens being introduced to novel ranges and naïve species is likely to increase. This will result in novel epidemics that the new hosts must adapt to in order to survive. The focal disease of this thesis, white-nose disease, provides a unique opportunity to explore host adaptation to a pathogen. Since its discovery in New York, USA, in 2006, white-nose disease has devastated bat populations across North America. In susceptible species, it causes wing damage, disrupts hibernation, and provokes strong immune responses in bats, resulting in widespread mortality. The Myotis bats appears to be particularly susceptible, with 10 of the 12 affected species belonging to this genus. The causative pathogen, Pseudogymnoascus destructans, is native to Northern Eurasia, where bats appear to be tolerant or resistant to the disease. This thesis explores the disparity between these responses on a variety of different levels, utilising the susceptible, North American Myotis lucifugus, and the tolerant, European Myotis myotis and Myotis brandtii. Firstly, I explored evidence of positive selection in tolerant and susceptible Myotis species, across the whole genome, and across a subset of genes with known immune function. While methodological challenges arising from non-comprehensive gene annotation prohibited identification of selection in functional categories, evidence of positive selection was found in some genes involved in inflammation, the adaptive Th17 response, and hibernation. I then assessed genetic variation in the M. brandtii populations across Europe and investigated whether this variation might be associated with white-nose prevalence. Populations across Europe were intermixed despite geographical barriers of distance, mountains and sea. However, several genes, including those linked to innate inflammation and circadian rhythms were linked to white-nose prevalence. The final analysis measured gene expression differences in infected M. myotis and M. lucifugus, during both late-hibernation, and at a novel timepoint after one month of healing. These results contrasted with previous literature in showing the tolerant M. myotis mounting a greater immune response during late hibernation than has previously been seen. The most striking aspect of this analysis was in observations of a continuing immune response in M. lucifugus one-month post-hibernation, not seen in M. myotis, which may be worsening immunopathology following infection. Together, this thesis highlights several genes with roles in innate inflammation, the adaptive and potentially immunopathological Th17 response, and hibernation. These comprise interesting gene targets for future research, as each has the potential to alter disease outcomes in infected species.
Additional file 2 of Does distance from a clinic and poverty impact visit adherence for noncommunicable diseases? A retrospective cohort study using electronic medical records in rural Haiti
Creators: name: Yan, Lily D.
name: Dufens Pierre-Louis
name: Isaac, Benito D.
name: Waking Jean-Baptiste
name: Vertilus, Serge
name: Fenelon, Darius
name: Hirschhorn, Lisa R.
name: Hibberd, Patricia L.
name: Emelia J. Benjamin
name: Bukhman, Gene
name: Kwan, Gene F.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Additional file 2. RECORD checklist. REporting of studies Conducted using Observational Routinely-collected Data (RECORD) statement checklist.
Index Codes for the Gaussian Broadcast Channel using Quadrature Amplitude Modulation
Creators: name: Natarajan, Lakshmi
name: Hong, Yi
name: Viterbo, Emanuele
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: We propose index codes, based on multidimensional QAM constellations, for the Gaussian broadcast channel, where every receiver demands all the messages from the source. The efficiency with which an index code exploits receiver side information in this broadcast channel is characterised by a code design metric called "side information gain". The known index codes for this broadcast channel enjoy large side information gains, but do not encode all the source messages at the same rate, and do not admit message sizes that are powers of two. The index codes proposed in this letter, which are based on linear codes over integer rings, overcome both these drawbacks and yet provide large values of side information gain. With the aid of a computer search, we obtain QAM index codes for encoding up to 5 messages with message sizes 2^m, m <= 6. We also present the simulated performance of a new 16-QAM index code, concatenated with an off-the-shelf LDPC code, which is observed to operate within 4.3 dB of the broadcast channel capacity.
description: Accepted for publication in IEEE Communications Letters. 4 pages, 2 figures, 1 table
Genetic identification of brain cell types underlying schizophrenia
Creators: name: Giusti-Rodriguez, P.
name: Muñoz-Manchado, A.B.
name: Crowley, J.J.
name: Breen, G.
name: Hodge, R.D.
name: O'Donovan, M.C.
name: Bakken, T.E.
name: Linnarsson, S.
name: Bryois, J.
name: Ryge, J.
name: Hjerling-Leffler, J.
name: Walters, J.T.R.
name: Sullivan, P.F.
name: Owen, M.J.
name: Miller, J.A.
name: Skene, N.G.
name: Gaspar, H.A.
name: Lein, E.S.
name: Pardiñas, A.F.
Publisher: name: Nature Publishing Group
Year: 2018

description: With few exceptions, the marked advances in knowledge about the genetic basis of schizophrenia have not converged on findings that can be confidently used for precise experimental modeling. By applying knowledge of the cellular taxonomy of the brain from single-cell RNA sequencing, we evaluated whether the genomic loci implicated in schizophrenia map onto specific brain cell types. We found that the common-variant genomic results consistently mapped to pyramidal cells, medium spiny neurons (MSNs) and certain interneurons, but far less consistently to embryonic, progenitor or glial cells. These enrichments were due to sets of genes that were specifically expressed in each of these cell types. We also found that many of the diverse gene sets previously associated with schizophrenia (genes involved in synaptic function, those encoding mRNAs that interact with FMRP, antipsychotic targets, etc.) generally implicated the same brain cell types. Our results suggest a parsimonious explanation: the common-variant genetic results for schizophrenia point at a limited set of neurons, and the gene sets point to the same cells. The genetic risk associated with MSNs did not overlap with that of glutamatergic pyramidal cells and interneurons, suggesting that different cell types have biologically distinct roles in schizophrenia.
Additional file 1 of Does distance from a clinic and poverty impact visit adherence for noncommunicable diseases? A retrospective cohort study using electronic medical records in rural Haiti
Creators: name: Yan, Lily D.
name: Dufens Pierre-Louis
name: Isaac, Benito D.
name: Waking Jean-Baptiste
name: Vertilus, Serge
name: Fenelon, Darius
name: Hirschhorn, Lisa R.
name: Hibberd, Patricia L.
name: Emelia J. Benjamin
name: Bukhman, Gene
name: Kwan, Gene F.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Additional file 1: Supplemental Materials. Supplemental Tables 1–9 and Supplemental figures 1–3. Supplemental Table 1 Adapted multidimensional poverty index. Supplemental Table 2: Alternative definitions of visit adherence measures. Supplemental Table 3: Univariate logistic regressions on factors associated with visit adherence measures in an NCD Clinic in rural Haiti. Supplemental Table 4: Sex and age adjusted multivariable logistic regressions for poverty and distance factors associated with visit adherence in an NCD Clinic in rural Haiti. Supplemental Table 5: Multivariable logistic regression on poverty and distance, using time travel instead of Euclidean distance, associated with visit adherence measures. Supplemental Table 6: Multivariable logistic regression on poverty and distance factors, with only MPI poverty, associated with visit adherence measures. Supplemental Table 7: Multivariable logistic regression on poverty and distance factors, with only hardship financing, associated with visit adherence measures. Supplemental Table 8: Multivariable logistic regression on disease severity, associated with visit adherence measures. Supplemental Table 9: Multivariable logistic regression on poverty and distance factors, adjusting for disease severity, associated with visit adherence measures. Supplemental Figure 1: Flow diagram of database linkage, and patient selection. Supplemental Figure 2: Density map of visit adherence measures. Supplemental Figure 3: Odds ratios for factors related to visit adherence measure outcomes.
(3669) Carolyn Peta Prendergast
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Comparative genomic evidence for the involvement of schizophrenia risk genes in antipsychotic effects
Creators: name: Bryois, J.
name: Quackenbush, C.R.
name: Kim, Y.
name: Crowley, J.J.
name: Ryan, A.K.
name: Sullivan, P.F.
name: Iglesias-Ussel, M.D.
name: De Villena, F.P.-M.
name: Nonneman, R.J.
name: Lee, P.H.
name: Sun, W.
name: Giusti-Rodriguez, P.
Publisher: name: Nature Publishing Group
Year: 2018

description: Genome-wide association studies (GWAS) for schizophrenia have identified over 100 loci encoding >500 genes. It is unclear whether any of these genes, other than dopamine receptor D 2, are immediately relevant to antipsychotic effects or represent novel antipsychotic targets. We applied an in vivo molecular approach to this question by performing RNA sequencing of brain tissue from mice chronically treated with the antipsychotic haloperidol or vehicle. We observed significant enrichments of haloperidol-regulated genes in schizophrenia GWAS loci and in schizophrenia-associated biological pathways. Our findings provide empirical support for overlap between genetic variation underlying the pathophysiology of schizophrenia and the molecular effects of a prototypical antipsychotic.
(3670) Frank Anthony Riley-Smith
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(3665) Tristram Riley-Smith
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
On decoherence in quantum gravity
Creators: name: Podolskiy, Dmitriy
name: Lanza, Robert
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: It was previously argued that the phenomenon of quantum gravitational decoherence described by the Wheeler-DeWitt equation is responsible for the emergence of the arrow of time. Here we show that the characteristic spatio-temporal scales of quantum gravitational decoherence are typically logarithmically larger than a characteristic curvature radius $R^{-1/2}$ of the background space-time with a factor under the logarithm proportional to $M_{P}^{2}/R$. This largeness is a direct consequence of the fact that gravity is a non-renormalizable theory, as the corresponding effective field theory is nearly decoupled from matter degrees of freedom in the physical limit $M_{P}\to\infty$. Therefore, as such, quantum gravitational decoherence is too ineffective to guarantee the emergence of the arrow of time at scales of physical interest. We argue that the emergence of the arrow of time is directly related to the nature and properties of physical observer.
description: 28 pages, 3 figures; matches version published in Annalen der Physik
Indigofera_amblyantha_Craib and Indigofera_pseudotinctoria_Matsum plastid genome
Creators: name: 熊艳丽(Yanli Xiong)
Publisher: name: CNGB
Year: 2023
Subjects: Assembly
Monoisolate

description: The mitochondrial and chloroplast genome of Indigofera_amblyantha_Craib and Indigofera_pseudotinctoria_Matsum were sequenced and assembled
Quantum coin flipping secure against channel noises
Creators: name: Zhang, Sheng
name: Zhang, Yuexin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: So far, most of existed single-shot quantum coin flipping(QCF) protocols failed in a noisy quantum channel. Here, we present a nested-structured framework that makes it possible to achieve partially noise-tolerant QCF, due to that there is a trade-off between the security and the justice correctness. It is showed that noise-tolerant single-shot QCF protocols can be produced by filling the presented framework up with existed or even future protocols. We also proved a lower bound of 0.25, with which a cheating Alice or Bob could bias the outcome.
description: 6 pages, 2 figures
label.switching: An R Package for Dealing with the Label Switching Problem in MCMC Outputs
Creators: name: Papastamoulis, Panagiotis
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computation (stat.CO)
subject: FOS: Computer and information sciences

description: Label switching is a well-known and fundamental problem in Bayesian estimation of mixture or hidden Markov models. In case that the prior distribution of the model parameters is the same for all states, then both the likelihood and posterior distribution are invariant to permutations of the parameters. This property makes Markov chain Monte Carlo (MCMC) samples simulated from the posterior distribution non-identifiable. In this paper, the \pkg{label.switching} package is introduced. It contains one probabilistic and seven deterministic relabelling algorithms in order to post-process a given MCMC sample, provided by the user. Each method returns a set of permutations that can be used to reorder the MCMC output. Then, any parametric function of interest can be inferred using the reordered MCMC sample. A set of user-defined permutations is also accepted, allowing the researcher to benchmark new relabelling methods against the available ones
description: Accepted to Journal of Statistical Software
(3663) Renee Wilson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Methodological toolkit for assessing the level of stability of agricultural enterprises
Creators: name: Sumets, Alexander
name: Kniaz, Sviatoslav
name: Heorhiadi, Nelli
name: Skrynkovskyy, Ruslan
name: Matsuk, Vasylyna
name: Sumets, Alexander
name: Kniaz, Sviatoslav
name: Heorhiadi, Nelli
name: Skrynkovskyy, Ruslan
name: Matsuk, Vasylyna
Publisher: name: Unknown
Year: 2022
Subjects: subject: Agribusiness
subject: enterprise
subject: resulting parameter
subject: stability
subject: stochastic series of values

description: Purpose. The purpose of the study is to develop methodological toolkit for identifying the level of stability of agricultural enterprises based on the study of stochastic series of values of the resulting parameters. Methodology / approach. During the study, a method of modeling stochastic quantities was used, in particular the Verhulst equation to study the dynamics of the values of the resulting parameter relative to a monotonically increasing series of values and different values of the coefficient of “density accumulation”. The GARCH model was used to predict the values of the variance of the resulting parameter, and regression analysis was used to determine the dependence of the state of enterprises on the factors of internal and external environments. Results. It is substantiated that the values of the logistic function of Verhulst imitate the behavior of a stochastic quantity. Therefore, this function can be used to measure the transition point of the system from a stable state to a state of instability. It is proved that, taking into account the stochastic and reflective nature of the development of agricultural enterprises, it is expedient to forecast their state on the basis of comparing the variances of the values of the performance parameter. It is reasoned that the application of the function of changing the degree coefficients allows obtaining the most complete information about the influence of subjective factors of the internal environment of agricultural enterprises on their state. Originality / scientific novelty. Methodological toolkit for identifying the level of stability of agricultural enterprises, which is based on the application of the Verhulst equation to study the dynamics of the values of the resulting parameter relative to the monotonically increasing series of values and different values of the coefficient of “density accumulation”, and, unlike existing parameter from the factors of internal and external environments of the agricultural enterprise. Practical value / implications. The practical value of the developed methodological toolkit is in the possibility of its use by managers of agricultural enterprises to forecast their state, taking into account the influence of internal and external factors. Given that the prediction is reduced to one resulting parameter, the proposed toolkit is easy to use. It is advisable to use it to justify regulatory decisions, in particular in the process of adaptive management and streamlining of personnel management processes and intellectual potential of employees.
Activity-dependent p25 generation regulates synaptic plasticity and aβ-induced cognitive impairment
Creators: name: Cho, S.
name: Zhou, Y.
name: Rudenko, A.
name: Tsai, L.-H.
name: Giusti-Rodríguez, P.
name: Guan, J.-S.
name: Pan, L.
name: Ota, K.T.
name: Delalle, I.
name: Seo, J.
name: Mungenast, A.E.
name: Patzke, H.
name: Park, C.
name: Madabhushi, R.
Publisher: name: Elsevier B.V.
Year: 2014

description: Cyclin-dependent kinase 5 regulates numerous neuronal functions with its activator, p35. Under neurotoxic conditions, p35 undergoes proteolytic cleavage to liberate p25, which has been implicated in various neurodegenerative diseases. Here, we show that p25 is generated following neuronal activity under physiological conditions in a GluN2B- and CaMKIIα-dependent manner. Moreover, we developed a knockin mouse model in which endogenous p35 is replaced with a calpain-resistant mutant p35 (Δp35KI) to prevent p25 generation. The Δp35KI mice exhibit impaired long-term depression and defective memory extinction, likely mediated through persistent GluA1 phosphorylation at Ser845. Finally, crossing the Δp35KI mice with the 5XFAD mouse model of Alzheimer's disease (AD) resulted in an amelioration of β-amyloid (Aβ)-induced synaptic depression and cognitive impairment. Together, these results reveal a physiological role of p25 production in synaptic plasticity and memory and provide new insights into the function of p25 in Aβ-associated neurotoxicity and AD-like pathology.
(3664) Margaret Cawthorn
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(3666) Fabienne Hillyard
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-Secretase (BACE1)
Creators: name: Gao, J.
name: Gräff, J.
name: Rei, D.
name: Tsai, L.-H.
name: Giusti-Rodríguez, P.
name: Soda, T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Alzheimer's disease (AD) is the most common cause of dementia, and is characterized by memory loss and cognitive decline, as well as amyloidβ (Aβ) accumulation, and progressive neurodegeneration. Cdk5 is a proline-directed serine/threonine kinase whose activation by the p25 protein has been implicated in a number of neurodegenerative disorders. The CK-p25 inducible mouse model exhibits progressive neuronal death, elevated Aβ, reduced synaptic plasticity, and impaired learning following p25 overexpression in forebrain neurons. Levels ofAβ, as well as the APP processing enzyme,β-secretase (BACE1), are also increased in CK-p25 mice. It is unknown what role increased Aβ plays in the cognitive and neurodegenerative phenotype of the CK-p25 mouse. In the current work, we restored Aβ levels in the CK-p25 mouse to those of wild-type mice via the partial genetic deletion of BACE1, allowing us to examine the Aβ- independent phenotype of this mouse model. We show that, in the CK-p25 mouse, normalization of Aβ levels led to a rescue of synaptic and cognitive deficits. Conversely, neuronal loss was not ameliorated. Our findings indicate that increases in p25/Cdk5 activity may mediate cognitive and synaptic impairment via an Aβ-dependent pathway in the CK-p25 mouse. These findings explore the impact of targeting Aβ production in a mouse model of neurodegeneration and cognitive impairment, and how this may translate into therapeutic approaches for sporadic AD.
Unraveling: A Podcast About Science, Technology, and Criminal Justice
Creators: name: Peaslee, Emma
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020
Subjects: Evidence, Criminal
Forensic genetics
Cold cases (Criminal investigation)
Interviews
Detectives

description: Less than two years after the Golden State Killer arrest, genetic genealogy is being used in police departments across the country to solve cold-cases, identify remains, and even overturn a conviction. The new technology has implications for thousands of unsolved cold-cases and unidentified bodies still out there. However, some of the larger companies have already become wary of police searches and have created specific guidelines to prevent the sharing of DNA without customers’ knowledge. Privacy advocates say this fear is warranted because while traditional police DNA databases only provide a genetic fingerprint, genetic genealogy databases can provide information about a person’s appearance, medical conditions, and even potential predispositions to mental health problems.3 The steps police are taking have led them to uncharted territory. 

What happens when technology advances before the regulations? My project will be several audio stories featuring people who are for and against this new technology. Who is benefitting and who could be - or already has been - hurt by genetic genealogy? Privacy advocates believe there is a reason to be concerned with law enforcement's unfettered access to people’s genetic information. According to a recent study, 60% of Americans of Northern European descent, the primary users, can be identified through the databases whether or not they’ve submitted their genetic information.4 In two to three years, that number is expected to be closer to 90%. The future of privacy and genetic genealogy will have implications for the American population whether they ever use the service.
A Herschel/HIFI Legacy Survey of HF and H2O in the Galaxy: Probing Diffuse Molecular Cloud Chemistry
Creators: name: Sonnentrucker, P.
name: Wolfire, M.
name: Neufeld, D. A.
name: Flagey, N.
name: Gerin, M.
name: Goldsmith, P.
name: Lis, D.
name: Monje, R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We combine Herschel observations of a total of 12 sources to construct the most uniform survey of HF and H2O in our Galactic disk. Both molecules are detected in absorption along all sight lines. The high spectral resolution of the Heterodyne Instrument for the Far-Infrared (HIFI) allows us to compare the HF and H2O distributions in 47 diffuse cloud components sampling the disk. We find that the HF and H2O velocity distributions follow each other almost perfectly and establish that HF and H2O probe the same gas-phase volume. Our observations corroborate theoretical predictions that HF is a sensitive tracer of H2 in diffuse clouds, down to molecular fractions of only a few percent. Using HF to trace H2 in our sample, we find that the N(H2O)-to-N(HF) ratio shows a narrow distribution with a median value of 1.51. Our results further suggest that H2O might be used as a tracer of H2 -within a factor 2.5- in the diffuse interstellar medium. We show that the measured factor of ~2.5 variation around the median is driven by true local variations in the H2O abundance relative to H2 throughout the disk. The latter variability allows us to test our theoretical understanding of the chemistry of oxygen-bearing molecules in the diffuse gas. We show that both gas-phase and grain-surface chemistry are required to reproduce our H2O observations. This survey thus confirms that grain surface reactions can play a significant role in the chemistry occurring in the diffuse interstellar medium n_H < 1000 cm^-3.
description: 53 pages; 12 figures, accepted for publication in ApJ main journal
Association of Lupus Nephritis Histopathologic Classification With Venous Thromboembolism—Modification by Age at Biopsy
Creators: name: Love, A.
name: Chapel Hill Alliance Promoting Excellence in Lupus (CHAPEL) group of investigators
name: Gibson, K.L.
name: Cooley, I.
name: Hogan, S.L.
name: Jennette, J.C.
name: Poulton, C.J.
name: Sheikh, S.Z.
name: Álvarez, C.
name: Blazek, L.N.
name: Derebail, V.K.
name: Falk, R.J.
Publisher: name: Elsevier Inc.
Year: 2021

description: Introduction: Lupus nephritis (LN) is an independent risk factor for venous thromboembolism (VTE). The risk of VTE has not been analyzed by International Society of Nephrology/Renal Pathology Society or World Health Organization LN class. Study goals were to measure VTE incidence in an LN patient cohort, to evaluate associations between VTE and LN class, and to investigate factors modifying associations between VTE and LN class. Methods: A retrospective analysis was performed using Glomerular Disease Collaborative Network data. Image-confirmed VTE was compared between patients with any LN class V lesion and patients with only LN class III or IV. Logistic regression was used to calculate odds ratios and 95% confidence intervals. Effect modification was assessed between main effect and covariates. Results: Our cohort consisted of 534 LN patients, 310 (58%) with class III/IV and 224 (42%) with class V with or without class III/IV, including 106 with class V alone. The VTE incidence was 62 of 534 (11.6%). The odds of VTE were not significantly different between patients with class III/IV and class V in adjusted analyses (odds ratio [OR] = 0.82, 95% confidence interval [CI] = 0.45−1.48). An age interaction was observed (P = 0.009), with increased odds of VTE with class III/IV diagnosed at a younger age (2.75, 0.90−8.41 estimated at age 16 years) and decreased odds with class III/IV diagnosed at an older age (0.23, 0.07−0.72 estimated at age 46 years), compared to class V. Conclusions: The VTE incidence was similar among patients with LN classes III/IV and V, suggesting that VTE risk is not limited to class V−related nephrotic syndrome and that age may modulate LN class-specific VTE risk.
Study Design and Baseline Characteristics of the CARDINAL Trial: A Phase 3 Study of Bardoxolone Methyl in Patients with Alport Syndrome
Creators: name: Stenvinkel, P.
name: Warady, B.A.
name: Pergola, P.E.
name: Inker, L.A.
name: Nozu, K.
name: Appel, G.B.
name: Meyer, C.J.
name: Block, G.A.
name: Knebelmann, B.
name: Silva, A.L.
name: Goldsberry, A.
name: Iijima, K.
name: Bangalore, S.
name: Chin, M.P.
name: Chapman, A.B.
name: Gibson, K.L.
name: Mariani, L.H.
name: Torra, R.
name: O'Grady, M.
name: Chertow, G.M.
name: Andreoli, S.
Publisher: name: S. Karger AG
Year: 2021

description: Introduction: Alport syndrome is a rare genetic disorder that affects as many as 60,000 persons in the USA and a total of 103,000 persons (<5 per 10,000) in the European Union [1, 2]. It is the second most common inherited cause of kidney failure and is characterized by progressive loss of kidney function that often leads to end-stage kidney disease. Currently, there are no approved disease-specific agents for therapeutic use. We designed a phase 3 study (CARDINAL; NCT03019185) to evaluate the safety, tolerability, and efficacy of bardoxolone methyl in patients with Alport syndrome. Methods: The CARDINAL phase 3 study is an international, multicenter, double-blind, placebo-controlled, randomized registrational trial. Eligible patients were of ages 12-70 years with confirmed genetic or histologic diagnosis of Alport syndrome, eGFR 30-90 mL/min/1.73 m2, and urinary albumin to creatinine ratio (UACR) ≤3,500 mg/g. Patients with B-type natriuretic peptide values >200 pg/mL at baseline or with significant cardiovascular histories were excluded. Patients were randomized 1:1 to bardoxolone methyl or placebo, with stratification by baseline UACR. Results: A total of 371 patients were screened, and 157 patients were randomly assigned to receive bardoxolone methyl (n = 77) or placebo (n = 80). The average age at screening was 39.2 years, and 23 (15%) were <18 years of age. Of the randomized population, 146 (93%) had confirmed genetic diagnosis of Alport syndrome, and 62% of patients had X-linked mode of inheritance. Mean baseline eGFR was 62.7 mL/min/1.73 m2, and the geometric mean UACR was 141.0 mg/g. The average annual rate of eGFR decline prior to enrollment in the study was -4.9 mL/min/1.73 m2 despite 78% of the patient population receiving ACE inhibitor (ACEi) or ARB therapy. Discussion/Conclusion: CARDINAL is one of the largest interventional, randomized controlled trials in Alport syndrome conducted to date. Despite the use of ACEi or ARB, patients were experiencing significant loss of kidney function prior to study entry.
APOL1 genotype-associated morphologic changes among patients with focal segmental glomerulosclerosis
Creators: name: Greenbaum, L.A.
name: Lafayette, R.A.
name: Lemley, K.V.
name: Hingorani, S.
name: Gibson, K.L.
name: Gadegbeku, C.A.
name: Patel, J.
name: Lieske, J.C.
name: Sambandam, K.K.
name: Vento, S.
name: Lin, J.
name: Hladunewich, M.A.
name: Kopp, J.B.
name: Meyers, K.E.
name: Reich, H.N.
name: Dell, K.M.
name: Fervenza, F.C.
name: Hogan, J.J.
name: Holzman, L.B.
name: Sampson, M.G.
name: Nast, C.C.
name: Zee, J.
name: Derebail, V.K.
name: Sethna, C.B.
name: Atkinson, M.A.
name: Hogan, M.C.
name: Fornoni, A.
name: Tuttle, K.R.
name: Singer, P.
name: Brown, E.
name: Zhdanova, O.
name: Kaskel, F.J.
name: Wang, C.-S.
name: Srivastava, T.
name: Adler, S.G.
name: Gipson, D.S.
name: McNulty, M.T.
name: Appel, G.
name: Kretzler, M.
name: Hodgin, J.B.
name: O'Toole, J.
name: Barisoni, L.
name: Jefferson, J.A.
name: Bagnasco, S.
name: Trachtman, H.
name: Chen, D.
name: Matar, R.B.
name: Athavale, A.M.
Publisher: name: Springer Science and Business Media Deutschland GmbH
Year: 2021

description: Background: The G1 and G2 alleles of apolipoprotein L1 (APOL1) are common in the Black population and associated with increased risk of focal segmental glomerulosclerosis (FSGS). The molecular mechanisms linking APOL1 risk variants with FSGS are not clearly understood, and APOL1’s natural absence in laboratory animals makes studying its pathobiology challenging. Methods: In a cohort of 90 Black patients with either FSGS or minimal change disease (MCD) enrolled in the Nephrotic Syndrome Study Network (58% pediatric onset), we used kidney biopsy traits as an intermediate outcome to help illuminate tissue-based consequences of APOL1 risk variants and expression. We tested associations between APOL1 risk alleles or glomerular APOL1 mRNA expression and 83 light- or electron-microscopy traits measuring structural and cellular kidney changes. Results: Under both recessive and dominant models in the FSGS patient subgroup (61%), APOL1 risk variants were significantly correlated (defined as FDR <0.1) with decreased global mesangial hypercellularity, decreased condensation of cytoskeleton, and increased tubular microcysts. No significant correlations were detected in MCD cohort. Independent of risk alleles, glomerular APOL1 expression in FSGS patients was not correlated with morphologic features. Conclusions: While APOL1-associated FSGS is associated with two risk alleles, both one and two risk alleles are associated with cellular/tissue changes in this study of FSGS patients. Our lack of discovery of a large group of tissue differences in FSGS and no significant difference in MCD may be due to the lack of power but also supports investigating whether machine learning methods may more sensitively detect APOL1-associated changes.
Additional file 1 of Associations between change in labour market policies and work stressors: a comparative longitudinal survey data analysis from 27 European countries
Creators: name: Lunau, T.
name: M. Wahrendorf
name: N. Dragano
name: J. Siegrist
name: K. A. Van Der Wel
name: M. Rigó
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Additional file 1 : List of underlying EWCS survey items.
Multiplicative expression for the coefficient in fermionic 3-3 relation
Creators: name: Korepanov, Igor G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: Algebraic Topology (math.AT)
subject: Quantum Algebra (math.QA)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 57R56 (Primary), 57Q99, 13P25 (Secondary)

description: Recently, a family of fermionic relations were discovered corresponding to Pachner move 3-3 and parameterized by complex-valued 2-cocycles, where the weight of a pentachoron (4-simplex) is a Grassmann-Gaussian exponent. Here, the proportionality coefficient between Berezin integrals in the l.h.s. and r.h.s. of such relations is written in a form multiplicative over simplices.
description: 19 pages, no figures
Infection-related acute care events among patients with glomerular disease
Creators: name: Zee, J.
name: Gibson, K.
name: Bomback, A.
name: Hogan, S.
name: CureGN Consortium
name: O'Shaughnessy, M.
name: Mottl, A.
name: Greenbaum, L.A.
name: Glenn, D.A.
name: Henderson, C.D.
name: Hu, Y.
name: Falk, R.
name: Mariani, L.
Publisher: name: American Society of Nephrology
Year: 2020

description: Background and objectives Infections contribute to patient morbidity and mortality in glomerular disease. We sought to describe the incidence of, and identify risk factors for, infection-related acute care events among Cure Glomerulonephropathy Network (CureGN) study participants. Design, setting, participants, & measurements CureGN is a prospective, multicenter, cohort study of children and adults with biopsy sample–proven minimal change disease, FSGS, membranous nephropathy, or IgA nephropathy/vasculitis. Risk factors for time to first infection-related acute care events (hospitalization or emergency department visit) were identified using multivariable Cox proportional hazards regression. Results Of 1741 participants (43%female, 41%,18 years, 68%White), 163 (9%) experienced infection-related acute care events over a median follow-up of 17months (interquartile range, 9–26months).Unadjusted incidence rates of infection-related acute care events were 13.2 and 6.2 events per 100 person-years among pediatric and adult participants, respectively. Among participants with versus without corticosteroid exposure at enrollment, unadjusted incidence rates were 50.6 and 28.6 per 100 person-years, respectively, during the first year of follow-up (adjusted hazard ratio for time to first infection, 1.31; 95% CI, 0.89 to 1.93), and 4.1 and 1.1 per 100 person-years, respectively, after 1 year of follow-up (hazard ratio, 2.99; 95%CI, 1.54 to 5.79). Hypoalbuminemia combined with nephrotic-range proteinuria (serum albumin #2.5 g/dl and urinary protein-creatinine ratio.3.5 mg/mg), compared with serumalbumin.2.5 g/dl and urinary protein-creatinine ratio#3.5 mg/mg, was associated with higher risk of time to first infection (adjusted hazard ratio, 2.49; 95% CI, 1.51 to 4.12). Conclusions Among CureGN participants, infection-related acute care events were common and associated with younger age, corticosteroid exposure, and hypoalbuminemia with proteinuria.
(3659) Frances Blacket Gill
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Validity of Urine NGALds Dipstick for Acute Kidney Injury in a Malawian Trauma Cohort
Creators: name: Munthali, C.K.
name: Smith, Z.
name: Charles, A.
name: Gower, E.W.
name: Golightly, Y.M.
name: Bjornstad, E.C.
name: Mottl, A.K.
name: Gibson, K.
name: Kamija, M.
name: Muronya, W.
name: Marshall, S.W.
Publisher: name: Elsevier Inc.
Year: 2020

description: Introduction: Acute kidney injury (AKI) is a major cause of mortality worldwide, particularly in low-resource settings with limited diagnostic testing. Neutrophil gelatinase-associated lipocalin (NGAL) has shown promise in predicting AKI. Nested within a larger, prospective cohort study evaluating AKI incidence in admitted trauma patients, our objective was to evaluate a novel dipstick, NGALds, for the prediction of AKI in Malawi, Africa. Methods: Participants were >6 months of age. Spearman rank correlation coefficients (R) assessed NGAL categories (negative [≤50 ng/ml], low risk [51−149 ng/ml], moderate risk [150−299 ng/ml], and high risk [≥300 ng/ml]) for the urine NGALds dipstick and laboratory-based NGAL Test. Results: We enrolled 285 participants (one-third children). Thirteen percent developed AKI. The dipstick captured 45 of 52 participants (86.5%) with moderate- or high-risk NGAL values on laboratory-based testing (R = 0.74). The dipstick had sensitivity of 44.4%, specificity of 73.5%, positive predictive value of 19.5%, and negative predictive value of 90.2% for predicting AKI. Acute kidney injury was associated with an increased risk of mortality (relative risk [RR] = 3.9, 95% confidence interval [CI] = 1.9−8.2), but mortality risk greatly increased among children who first had a positive (≥150 ng/ml) NGALds result (RR = 12.0, 95% CI = 1.8−78.4). Conclusions: The NGALds dipstick performed similarly to the NGAL Test in this low-resource setting and may be a useful tool to rule out AKI. It may be even more important in predicting high mortality risk among children.
(3661) Ann Dolby
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(3660) Isabel Jeans
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.