cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
S.M.A.R.T. Steroids - Nmda Receptors Modulators Acting As Cns Therapeutics
Creators: name: E. Kudova
name: L. Vyklicky
name: M. Smidkova
name: M. Nekardova
name: E. Zbornikova
name: M. Balastik
name: K. Vales
name: P. Mares
name: J. Palecek
Publisher: name: Zenodo
Year: 2016

description: N-Methyl-D-aspartate receptors (NMDARs) play an important role in development, synaptic plasticity, learning, and memory, however, abnormal activation or miss-regulation of NMDA receptors have been shown to mediate neuronal degeneration and ultimately cell death. The NMDA receptor activity can be modulated by various ligands, including neurosteroids. To find novel potentially beneficial drugs to treat neurological damage/neurodegeneration is one of the most investigated areas in contemporary pharmacology and neuroscience. Therefore, we designed and synthesized SMART Steroids - Steroidal Molecules As Rapid-acting Therapeutics. SMART Steroids are neuroactive molecules, targeting primarily the NMDA receptors and show neuroprotective properties and minimal side effects in animal models. Our screening pipeline covers physicochemical and biological properties like: (i) solubility (DLS); (ii) lipophilicity (logP, logD, ?Gsolv); (iii) patch-clamp recordings from HEK293 cells assessing NMDAR inhibition rates and IC50 values; (iv) Caco-2 assay, (v) treatment of glutamate and NMDA-induced neurotoxicity (survival rate, caspase-3, intracellular calcium levels, ROS); (vi) in vitro growth of postnatal neurons after neurosteroid administration, (vii) models of animal behavior (open field, elevated plus maze, forced swim test, etc.); (viii) PTZ-induced seizures; (ix) paclitaxel-induced peripheral neuropathy; (x) pharmacokinetic properties.
Our unique SMART Steroids: (i) are potent modulators of NMDA Receptors (with IC50 values from 90 nM to 10 ?M); (ii) are significantly more potent at inhibiting rather tonically than synaptically activated NMDARs compared to memantine; (iii) do cross blood-brain-barrier; (iv) are stable against fast metabolic degradation while maintaining the biological activity; (v) show neuroprotective effects in animal models; (vi) do not show side effects of NMDA antagonism in animal models; (v) reveal low toxicity in vitro and in vivo; (vi) have therapeutic effects in animal models (mice and rats).
Our results indicate that these compounds may be beneficial in treatment of several neurological diseases like epilepsy, neuropathic pain, AD, PD and others.
The project is offered for co-development and licensing. Broad patent portfolio has been developed protecting compounds, production and its use for treatment in neurology etc. (EP 2313424, US 2012071453, EP 2675821, PCT/CZ2015/000096).
"Can you spare any dignity, please?" : begging as contrary to the prohibition on "degrading treatment" in human rights law: an excursion in jurisprudence...
Creators: name: Webster, Elaine
Publisher: name: My University
Year: 2005
Subjects: The Council of Europe’s Committee for the Prevention of Torture and Inhuman or Degrading Treatment and punishment
Convention against Torture and Other Cruel, Inhuman or Degrading Treatment
human rights
inhuman treatment

description: Second semester University: KU Leuven
title: First-person shooters and the third-person effect
Creators: name: Scharrer, Erica
name: Leone, Ron
Publisher: name: University of Massachusetts Amherst
Year: 2008

description: A sample of 118 U.S. 6th and 7th graders was used to examine early adolescents’ views of whether video games negatively influence themselves, others of the same age, and younger others. Six specific games ranging in rating from E for Everyone to M for Mature were listed for the early adolescents to respond to, with questions asked about both potential influence and whether young people should be allowed to play the games. Results support a third‐person perception that grew as the rating of the game became more restrictive and as the “other” group in question became younger. The presence of rules set by parents about video game use was a positive predictor of perceptions of influence on self and others.
Long Fluorescence Lifetime Or Label-Free? A Comparative Study Of High Throughput Screening Methodologies To Minimise Assay Interferences
Creators: name: P. Craggs
Publisher: name: Zenodo
Year: 2016

description: Fluorescence based assay methodologies are one of the most commonly used detection technologies for modern high throughput screening (HTS). However, the majority of fluorescence-based techniques are affected by a number of compound interferences, most notably; quenching, auto-fluorescence and light scattering. Fluorescence lifetime (FLT) is an under-used fluorescence screening methodology that measures the time a fluorophore spends in the excited state before returning to the ground state. Detecting fluorescence lifetime is an attractive assay readout due to its ability to mitigate some of the aforementioned compound-related assay interferences, in addition to being insensitive to well-to-well volume variations and less prone to turbidity by precipitating particles.
The utilisation of Mass spectrometry (MS) as a label-free, direct-detection methodology for screening of enzyme targets has been demonstrated to reduce assay interferences, when compared to indirect, fluorescent technologies. The Aglient RapidFire platform, which utilises solid phase extraction based techniques, has become widely used in drug discovery and is considered the optimal approach for low interference, medium throughput, enzyme compound screening and profiling. There are however disadvantages to using MS-based technologies, including the cost and complexity of the instrumentation and limitations in compound screening throughput.
To assess the suitability of FLT for use as as both a high throughput screening and hit qualification assay technology we have generated comparative data sets, using both the ?gold standard? RapidFire MS and the widely used, HTS-suitable, Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) methodology. These data demonstrate that FLT has a low incidence of interference, correlates well with RapidFire MS and is ammeable for use as a HTS assay format. Furthermore, we demonstrate that using lifetime, combined with features of the ameon FLT microplate reader and FLEXYTE assay reagents, we enable fluorescence recovery of true inhibitors and qualification of compound interference mechanisms.
Guia Facilitador do Processo de Enfermagem no Sistema AGHUx (CTI adulto)
Creators: name: Milena Rubis da Costa
name: Lais de Rezende Thurler
name: Érica Brandão de Moraes
name: Katerine Moraes dos Santos
name: Geilsa Cavalcanti
name: Raquel Dias dos Santos Dantas
name: Debora Teixeira Machado
name: Alessandra Cristina de Oliveira Aquino
name: Caroline Pereira Ribeiro Tomaz
Publisher: name: Zenodo
Year: 2025
Subjects: CTI
UTI
Processo de Enfermagem
Diagnóstico de Enfermagem
Planejamento de Enfermagem
AGHUx
EBSERH
Enfermagem

description: Produto desenvolvido durante a disciplina de Gerência de Enfermagem II, do curso de graduação em Enfermagem da Escola de Enfermagem Aurora de Afonso Costa - Universidade Federal Fluminense, para implementação no CTI-adulto do Hospital Universitário Antônio Pedro. O presente guia contém 59 diagnósticos de enfermagem prioritários do setor, a definição de cada um deles, suas intervenções e os respectivos aprazamentos recomendados, com o intuito de melhorar as etapas de Diagnóstico e Planejamento do Processo de Enfermagem.
Supplementary document for Intracavity filtering in SESAM mode-locked fiber lasers: soliton effects and noise performance - 6531550.pdf
Creators: name: Boguslawski, Jakub
name: Sterczewski, Lukasz
name: Stachowiak, Dorota
name: Sobon, Grzegorz
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental document
Ein Datensatz handgezeichneter UML-Klassendiagramme für maschinelle Lernverfahren
Creators: name: Schumacher, Philipp Nicolas
Publisher: name: Karlsruher Institut für Technologie (KIT)
Year: 2021

description: Klassendiagramme ermöglichen die grafische Modellierung eines Softwaresystems. Insbesondere zu Beginn von Softwareprojekten entstehen diese als handgezeichnete Skizzen auf nicht-digitalen Eingabegeräten wie Papier oder Whiteboards. Das Festhalten von Skizzen dieser Art ist folglich auf eine fotografische Lösung beschränkt. Eine digitale Weiterverarbeitung einer auf einem Bild gesicherten Klassendiagrammskizze ist ohne manuelle Rekonstruktion in ein maschinell verarbeitbares Diagramm nicht möglich. Maschinelle Lernverfahren können durch eine Skizzenerkennung eine automatisierte Transformation in ein digitales Modell gewährleisten. Voraussetzung für diese Verfahren sind annotierte Trainingsdaten. Für UML-Klassendiagramme sind solche bislang nicht veröffentlicht. Diese Arbeit beschäftigt sich mit der Erstellung eines Datensatzes annotierter UML-Klassendiagrammskizzen für maschinelle Lernverfahren. Hierfür wird eine Datenerhebung, ein Werkzeug für das Annotieren von UML-Klassendiagrammen und eine Konvertierung der Daten in ein Eingabeformat für das maschinelle Lernen präsentiert. Der annotierte Datensatz wird im Anschluss anhand seiner Vielfältigkeit, Detailtiefe und Größe bewertet. Zur weiteren Evaluation wird der Einsatz des Datensatzes an einem maschinellen Lernverfahren validiert. Das Lernverfahren ist nach dem Training der Daten in der Lage, Knoten mit einem $F_1$-Maß von über 99%, Textpositionen mit einem $F_1$-Maß von über 87% und Kanten mit einem $F_1$-Maß von über 71% zu erkennen. Die Evaluation zeigt folglich, dass sich der Datensatz für den Einsatz maschineller Lernverfahren eignet.
September 11 and the revitalised usage of Rasterfahndung method in Germany to detect "sleepers", impacting the right to private life and the right to non-discrimination
Creators: name: Tekes Calikusu, Ruken
Publisher: name: My University
Year: 2002
Subjects: European Convention on Human Rights
human rights
Germany
September 11th 2001
terrorism

description: Second semester University: University of Vienna
title: Laughing to keep from crying: Humor and aggression in television commercial content
Creators: name: Scharrer, Erica
name: Bergstrom, Andrea
name: Paradise, Angela
name: Ren, Qianqing
Publisher: name: University of Massachusetts Amherst
Year: 2006

description: This study found that a week of prime-time programming on the broadcast networks yielded 4,347 commercial messages (either for products/services or movie trailers/television program promotions), of which 536 (12.3%) contained some form of aggression (physical, verbal, or "fortuitous"). Those 536 messages then formed the sample used in this content analysis. Among the key findings, it was found that just over half of the commercials combined aggression with humor. Humor was more common when the aggression was fortuitous. Psychoanalytic humor was the most frequently employed humor technique, followed by incongruity and then superiority.
Maldi Mass Spectrometry: A Label-Free Solution For Ultra-High-Throughput Screening
Creators: name: M. Hamester
name: J. Fuchser
Publisher: name: Zenodo
Year: 2016

description: Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry is a well-established mass spectrometric technique. Mentionable are for example the capabilities for imaging which are unequivocally unique and offer valuable information about drug distribution in tissue samples. However, in terms of speed there was need for improvement, which is now addressed in the latest MALDI Time of Flight (TOF) mass spectrometers (rapifleX, Bruker Daltonics, Bremen, Germany). A breakthrough was the development of a new 10 kHz Nd:YAG laser system in combination with the 3 D smart beam technology and new laser optics which could accelerate the speed of MALDI TOF-MS significantly. Additionally the 355 nm laser beam could be improved to reach 5 ?m in spatial resolution. Imaging applications are now possible with 40 to 50 pixel per second vs 2-3 pixel per second with previous models. Those key performance characteristics were a milestone for imaging measurements, however not just beneficial for imaging but for ultra-high-throughput screening (MALDI-uHTS) just as well: MALDI mass spectrometry offers fast label free screening of biochemical assays; the monitoring of substrates and all products, and results in reliable determination of IC50 (half maximal inhibitory concentration) values, avoiding false positives. In comparison with conventional mass spectrometric methods, such as multiplexed liquid chromatography-mass spectrometry (LC-MS) and solid phase extraction (SPE-MS) methods MALDI TOF-MS is between 20 to 100 times faster and benefits from significant reduced solvent and sample usage.The presentation will demonstrate all the relevant achievements in MALDI TOF-MS. However, the focus will be the translation of technical enhancements to application benefits for imaging and MALDI-uHTS using the latest 10 kHz MALDI Smart Beam laser technology. Furthermore the presentation will describe the necessity to develop suitable assays for MALDI mass spectrometry.
Supplemental Material, Supplemental_manuscript_20171121 - Human iPS Cell–based Liver-like Tissue Engineering at Extrahepatic Sites in Mice as a New Cell Therapy for Hemophilia B
Creators: name: Okamoto, Ryota
name: Takayama, Kazuo
name: Akita, Naoki
name: Nagamoto, Yasuhito
name: Hosokawa, Daiki
name: Iizuka, Shunsuke
name: Fuminori Sakurai
name: Suemizu, Hiroshi
name: Ohashi, Kazuo
name: Mizuguchi, Hiroyuki
Publisher: name: SAGE Journals
Year: 2018
Subjects: Medicine
Cell Biology

description: Supplemental Material, Supplemental_manuscript_20171121 for Human iPS Cell–based Liver-like Tissue Engineering at Extrahepatic Sites in Mice as a New Cell Therapy for Hemophilia B by Ryota Okamoto, Kazuo Takayama, Naoki Akita, Yasuhito Nagamoto, Daiki Hosokawa, Shunsuke Iizuka, Fuminori Sakurai, Hiroshi Suemizu, Kazuo Ohashi, and Hiroyuki Mizuguchi in Cell Transplantation
title: SYSBAT - An Application to the Building Production Based on Computer Supported Cooperative Work
Creators: name: Ameziane, Farid
name: Lasserre, Stephane
Publisher: name: Bauhaus-Universität Weimar
Year: 2003
Subjects: subject: Bauplanung
subject: Bauausführung
subject: Computerunterstütztes Verfahren
subject: 620

description: Our proposed solution is to enable partners of a construction project to share all the technical data produced and handled during the building production process by building a system through the use of internet technology. The system links distributed databases and allows building partners to access remotely and manipulate specific information. It provides an updated building representation that is being enriched and refined all along the building production process. A recent collaboration with Nemetschek France (subsidiary company of Nemetschek AG, AEC CAD software leader) focus on a building product repository available in a web context. The aim is to help building project actors to choose a technical solution that fits its professional needs, and maintain our information system with up to date information. It starts with the possibility to build on line building product catalogs, in order to link Allplan CAD entities with building technical features. This paper presents the conceptual approaches on which our information system is built. Starting from a general organization diagram organization, we focus on the product and the description branches of construction works (including last IFC model specifications). Our aim is to add decisional support to the construction works selection process. To do so, we consider the actor's role upon the system and the pieces of information each one needs to achieve a given task.
description: Internationales Kolloquium über Anwendungen der Informatik und Mathematik in Architektur und Bauwesen : 10. bis 12.06.2003, Bauhaus-Universität Weimar, vol. 16, 2003
Supplemental_Material - Local Managerial Perceptions of Intergovernmental Management
Creators: name: Fowler, Luke
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 160509 Public Administration
subject: FOS: Political science
subject: 160607 International Relations

description: Supplemental_Material for Local Managerial Perceptions of Intergovernmental Management by Luke Fowler in State and Local Government Review
Supplemental Material, Electronic_file_1_7mars2018 - Initiative for Burnout of ICU Caregivers: Feasibility and Preliminary Results of a Psychological Support
Creators: name: Ricou, Bara
name: Gigon, Fabienne
name: Durand-Steiner, Edith
name: Liesenberg, Maud
name: Chemin-Renais, Christine
name: Merlani, Paolo
name: Delaloye, Sylvette
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 110305 Emergency Medicine
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 110203 Respiratory Diseases

description: Supplemental Material, Electronic_file_1_7mars2018 for Initiative for Burnout of ICU Caregivers: Feasibility and Preliminary Results of a Psychological Support by Bara Ricou, Fabienne Gigon, Edith Durand-Steiner, Maud Liesenberg, Christine Chemin-Renais, Paolo Merlani, and Sylvette Delaloye in Journal of Intensive Care Medicine
DS1_JVDI_10.1177_1040638719839110 – Supplemental material for Baseline urinalysis values in common bottlenose dolphins under human care in the Caribbean
Creators: name: Jiménez-Zucchet, Natalia
name: Alejandro-Zayas, Tamara
name: Alvarado-Macedo, Christian A.
name: Arreola-Illescas, María Renée
name: Benítez-Araiza, Lissette
name: Bustamante-Tello, Lilian
name: Cruz-Martínes, Danilo
name: Falcón-Robles, Nayeli
name: Garduño-González, Luz
name: López-Romahn, María Concepción
name: Martínez-Taylor, Ana Michelle
name: Mingramm-Murillo, Adriana
name: Ortíz, Carlos
name: Rivera-Guzmán, Antonio L.
name: Sabater-Durán, Rocío
name: Sánchez-Jiménez, Angélica
name: Sánchez-Okrucky, Roberto
name: Staggs, Lydia
name: Torres-Salcedo, Raúl
name: Vences-Fernández, María
name: Rivera-Marchand, Bert
name: Mignucci-Giannoni, Antonio A.
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine
subject: 70706 Veterinary Medicine
subject: FOS: Veterinary sciences

description: Supplemental material, DS1_JVDI_10.1177_1040638719839110 for Baseline urinalysis values in common bottlenose dolphins under human care in the Caribbean by Natalia Jiménez-Zucchet, Tamara Alejandro-Zayas, Christian A. Alvarado-Macedo, María Renée Arreola-Illescas, Lissette Benítez-Araiza, Lilian Bustamante-Tello, Danilo Cruz-Martínes, Nayeli Falcón-Robles, Luz Garduño-González, María Concepción López-Romahn, Ana Michelle Martínez-Taylor, Adriana Mingramm-Murillo, Carlos Ortíz, Antonio L. Rivera-Guzmán, Rocío Sabater-Durán, Angélica Sánchez-Jiménez, Roberto Sánchez-Okrucky, Lydia Staggs, Raúl Torres-Salcedo, María Vences-Fernández, Bert Rivera-Marchand and Antonio A. Mignucci-Giannoni in Journal of Veterinary Diagnostic Investigation
In Silico Docking Study of AAC(3) Enzyme with Aminoglycosides
Creators: name: Goto-Yamada, Shino
Publisher: name: Zenodo
Year: 2024
Subjects: AutoDock Vina
aminoglycoside N-acetyltransferase

description: Molecular Docking result

These data are the results of binding simulations between the crystal structure of AAC(3) (PDB:6bvc) and hygromycin, gentamicin, kanamycin, neomycin, geneticin, and sisomycin, generated using AutoDock Vina 1.2.5 via SwissDock (https://www.swissdock.ch). The output of each calculation is stored in the respective folder for each compound, and all results are summarized in an Excel file (result.xlsx). The structural information of the componds used in the calculations is also included in this Excel file.
Quantitative High-Content Screening Methods Reveal A Regulation Of Cell-To-Cell Variability Of The Energy Metabolism Of Brain Cells
Creators: name: G. Azarias
Publisher: name: Zenodo
Year: 2016

description: Astrocytes are non-neuronal cells tiling the entire central nervous systems. They are vital for neural circuit function but have traditionally been viewed as simple, homogenous cells that serve the same essential supportive roles everywhere. However, astrocytes are subject to intrinsic noise, signaling pathways and control mechanisms leading to a cell-to-cell variability, whose functional relevance poorly remains poorly understood. Recent evidence indicated that single astrocytes release variable concentrations of lactate in response to stimulation, raising the possibility that they have different energy metabolisms.
To investigate this hypothesis, we used high-content screening methods to monitor at the single cell level the variability in cellular ATP level in cultured astrocytes. An automated image analysis pipeline enabled the time-resolved quantification of both, the single-cell ATP level and the coefficient of variation in a cellular population. At resting state, astrocytes exhibited a significant variability in cellular ATP levels. As previously reported, glutamate induced a decrease in cellular ATP levels that recovered after stimulation. During the glutamatergic stimulation, the heterogeneity in the cellular ATP level decreased, suggesting that the decrease in cellular energy status is potentially regulated to avoid decreasing below a biological threshold. Interestingly, the cytosolic ATP level increased during recovery to a similar level among cells, independently from their basal cellular ATP which further decreased the heterogeneity in cellular ATP levels after stimulation.
Therefore, our results suggest that glutamatergic stimulation decreases the heterogeneity in energy metabolism in astrocytes. We speculate that the change in metabolic heterogeneity aims to prime the population to answer more rapidly a next stimulation challenge.
Complexities Supplemental Tables -Supplemental material for Improving spatial decision making using interactive maps: An empirical study on interface complexity and decision complexity in the North American hazardous waste trade
Creators: name: Vincent, Kristen
name: Roth, Robert E
name: Moore, Sarah A
name: Qunying Huang
name: Lally, Nick
name: Sack, Carl M
name: Nost, Eric
name: Rosenfeld, Heather
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: Geography
subject: 120599 Urban and Regional Planning not elsewhere classified
subject: FOS: Social and economic geography

description: Supplemental material, Complexities Supplemental Tables for Improving spatial decision making using interactive maps: An empirical study on interface complexity and decision complexity in the North American hazardous waste trade by Kristen Vincent, Robert E Roth, Sarah A Moore, Qunying Huang, Nick Lally, Carl M Sack, Eric Nost and Heather Rosenfeld in Environment and Planning B: Urban Analytics and City Science
Appendix_Grimshaw – Supplemental material for Market Exposure and the Labour Process: The Contradictory Dynamics in Managing Subcontracted Services Work
Creators: name: Grimshaw, Damian
name: Cartwright, Jo
name: Keizer, Arjan
name: Rubery, Jill
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business

description: Supplemental material, Appendix_Grimshaw for Market Exposure and the Labour Process: The Contradictory Dynamics in Managing Subcontracted Services Work by Damian Grimshaw, Jo Cartwright, Arjan Keizer and Jill Rubery in Work, Employment and Society
title: Familien im Kontext von Herkunft, Migration und neuer Heimat
Creators: name: Sabsabe, Ahmad Usamah
Publisher: name: Katholische Hochschule Nordrhein-Westfalen, Köln
Year: 2024
Subjects: subject: 300 Sozialwissenschaften

description: Die Bachelorthesis untersucht die vielschichtigen Veränderungen im Familienleben syrischer Migrant:innen, die sich als Folge der Flucht nach Deutschland ergeben (können). Es werden zum einen die herkunfts- und (post-)migrationsbezogenen Herausforderungen fokussiert, die diese Familien im neuen gesellschaftlichen Kontext erleben. Zum anderen werden aber auch die Ressourcen beleuchtet, die die Familien mitbringen und die sich aufgrund ihrer Erfahrungen entwickeln. Hierdurch wird die defizitorientierte Perspektive verlassen, die in der Migrationsforschung häufig vorherrscht. Die Arbeit leistet einen Beitrag zum Verständnis der Lebensrealitäten migrierter bzw. geflüchteter Familien.

Die Arbeit basiert auf einem leitfadengestützten Interview mit einer syrischen Mutter, die seit 2016 in Deutschland lebt. Durch die qualitative Inhaltsanalyse dieses Interviews entsteht ein detailliertes Bild der familiären Prägungen und Ankommensprozesse an einem konkreten Beispiel. Aus der Analyse werden Handlungsempfehlungen für Akteure der Sozialen Arbeit abgeleitet, mit denen der Prozess unterstützt werden kann.

In die Arbeit ist die persönliche Perspektive des Autors als ein 2015 aus politischen Gründen Geflüchteter integriert, womit das situierte Wissen des Betroffenen in die Arbeit miteinfließt und zugleich kritisch reflektiert wird. Mit diesem Ansatz wird die vorherrschende Subjekt-Objekt-Beziehung in der Forschung in Frage gestellt. Die Arbeit ist ein Beispiel für den bisher wenig vertretenen Ansatz postmigrantischer Forschung in der Sozialen Arbeit.
Supplementary_table – Supplemental material for Immunoexpression of BAP1, ROS1, and ALK in Spitzoid Melanocytic Tumors
Creators: name: Cardili, Leonardo
name: Viana, Cristiano Ribeiro
name: Andressa Germano
name: Fernandes, Mariana
name: Barcellos, Denise
name: Landman, Gilles
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 110323 Surgery
subject: FOS: Clinical medicine
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified

description: Supplemental material, Supplementary_table for Immunoexpression of BAP1, ROS1, and ALK in Spitzoid Melanocytic Tumors by Leonardo Cardili, Cristiano Ribeiro Viana, Andressa Germano, Mariana Fernandes, Denise Barcellos and Gilles Landman in International Journal of Surgical Pathology
Supplement_1 - Reversing the U: New Evidence on the Internet and Democracy Relationship
Creators: name: Zang, Leizhen
name: Xiong, Feng
name: Gao, Yanyan
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: Science Policy
subject: Sociology
subject: FOS: Sociology

description: Supplement_1 for Reversing the U: New Evidence on the Internet and Democracy Relationship by Leizhen Zang, Feng Xiong, and Yanyan Gao in Social Science Computer Review
Supplementary_tables - Effect of High-Fat Diet on Immature Female Mice and Messenger and Noncoding RNA Expression Profiling in Ovary and White Adipose Tissue
Creators: name: Huang, Bin-bin
name: Liu, Xiao-Chun
name: Qin, Xiao-yun
name: Chen, Jie
name: Ren, Pei-gen
name: Deng, Wei-Fen
name: Zhang, Jian
Publisher: name: SAGE Journals
Year: 2018
Subjects: Endocrinology
Pharmacology and Pharmaceutical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: Supplementary_tables for Effect of High-Fat Diet on Immature Female Mice and Messenger and Noncoding RNA Expression Profiling in Ovary and White Adipose Tissue by Bin-bin Huang, Xiao-Chun Liu, Xiao-yun Qin, Jie Chen, Pei-gen Ren, Wei-Fen Deng, and Jian Zhang in Reproductive Sciences
Possible genotoxic effects of antihypertensive drug active ingredients Amlodipine and Ramipril
Creators: name: Gunaydin, Oznur
name: Avuloglu Yilmaz, Ece
Publisher: name: Journal of Biological Research - Thessaloniki
Year: 2024
Subjects: Amlodipine; Ramipril; genotoxicity; human lymphocytes

description: Antihypertensive drugs are used to keep high blood pressure within a certain range and in balance. Long-term use of
antihypertensives may be required for therapeutic purposes. Amlodipine, which is the active ingredient of antihypertensive
drugs, acts as a calcium channel blocker, and Ramipril acts as an angiotensin converting enzyme (ACE) inhibitor. In this study,
in vitro genotoxic effects of Amlodipine and Ramipril were determined in human peripheral blood lymphocytes. Chromosomal
aberrations (CAs) and micronucleus (MN) assays were examined using concentrations of 0.39, 0.78, 1.56, 3.13, 6.25 μg mL-1
for Amlodipine and 19.53, 39.06, 78.13, 156.25, 312.50 μg mL-1 for Ramipril. The effects of these active ingredients on mitotic
index (MI) and nuclear division index (NDI) were also investigated. As a result, Amlodipine did not cause a significant change
in CA frequency compared to the control and solvent control at both 24 and 48-h treatment periods. Ramipril increased CAs
at the three highest concentrations (78.13, 156.25 and 312.50 μg mL-1) only at 48-h. Both active ingredients decreased MI at
high concentrations at all treatment times. Amlodipine did not cause a significant difference in MN and NDI values compared
to control and solvent control. Besides, Ramipril treatment caused an increase in MN frequency again at high concentrations.
In addition, it was determined that it had no effect on NDI. It was concluded that Amlodipine may not cause genotoxic
effects in human lymphocytes in vitro, while Ramipril may be genotoxic only at high concentrations.
description: Journal of Biological Research - Thessaloniki, Vol 31 (2024)
Dna Encoded Library Derived Molecule Properties And Library Productivity
Creators: name: O. Eidam
Publisher: name: Zenodo
Year: 2016

description: NA encoded library (DEL) screens allow for screening of millions of small molecules in a simple manner and provide novel chemical starting points in target-based hit identification. At Roche Innovation Center Basel we analyzed the physical properties, novelty, or structural diversity of 57 small molecules derived from two DNA encoded library screens run against two protein targets, employing mixtures of 16 different libraries.
In this presentation I will provide an assessment of the physical properties of 57 DEL-derived molecules from two drug target screens with an emphasis on drug-likeness, diversity and novelty, and a comparison to publicly available chemical space.
I will also highlight our observations related to the productivity of DNA encoded libraries: the total number of different small molecule structures potentially contained within each of the 16 libraries screened lies between 106 (1 million) to 1011 (100 billion) unique molecules; the median is 30 million unique molecules. We find that there is no clear relationship between the size of a library and its productivity, which we define as the number of active clusters obtained from a library (Figure 1). Empirical reasons for this finding and its implications for the design of future DNA encoded libraries will be discussed.
Discovery Of Ltx-315 - A Potential First-In-Class Oncolytic Peptide
Creators: name: B.E. Haug
Publisher: name: Zenodo
Year: 2016

description: Cationic antimicrobial peptides derived from host defense peptides (HDPs), which have important roles in the first line defense against pathogens for most species, have been targeted as novel antimicrobials and also novel anticancer agents. In many cases, the antimicrobial and cytotoxic activities stem from peptide-membrane interactions implicating anionic constituents on bacterial cell surfaces and membranes in cancer cells. The membranolytic mode of action of cationic anticancer peptides includes the release of danger- associated molecular pattern molecules (DAMPs) and tumor antigens from cancer cells, resulting in regression of solid tumors and systemic tumor specific immune responses. Thus, the concept of oncolytic peptides as a novel therapeutic modality has emerged as a promising immunotherapeutic strategy for cancer. In our efforts to develop oncolytic peptides, initially through modification of the HDP bovine lactoferricin, we have identified a series of chemically modified 9-mer cationic peptides with high cytotoxic activity against both drug-resistant and drug-sensitive cancer cells and lower toxicity towards normal cells. Among these peptides, LTX-315 displayed superior anti-cancer activity and was selected as a lead candidate. Preclinical studies showed that LTX-315 has relatively high plasma protein binding abilities and a human plasma half-life of 160 min. In addition LTX-315 demonstrated relatively low ability to inhibit CYP450 enzymes and was metabolized into non-toxic metabolites. LTX-315 is now in development as a new anticancer agent for intratumoral administration, and is currently being evaluated in a phase I/IIa study.

Disclosure: BEH is a shareholder in Lytix Biopharma AS. BM is a shareholder and employee of Lytix Biopharma AS. KAC receives financial support from and is a shareholder in Lytix Biopharma AS. JSS and ?R are co-founders, shareholders and employees of Lytix Biopharma AS. WS receives financial support from Lytix Biopharma AS.
DIDAKTIK TIZIM MAZMUNIDA O'QITUVCHI VA O'QUVCHI MUNOSABATLARINI INSONPARVARLASHTIRISH
Creators: name: Qalandarova, Gulyor
Publisher: name: Zenodo
Year: 2025

description: Ushbu maqolada didaktik tizim mazmunida o'qituvchi va o'quvchi munosabatlarini insonparvarlashtirish, uni tashkil etishning metod va shakllari yoritilgan.
Dialogue or "in the tunnel at the end of the light" : an apology in defence of some bilateral human rights dialogues with China and their "tangible" results in terms of change in Chinas human rights cognitive behaviour
Creators: name: Tota, Tiziana
Publisher: name: My University
Year: 2004
Subjects: foreign relations
China
human rights
international relations

description: Second semester University: University of Southern Denmark. Copenhagen.
A plight without a legal referent : protection of indigenous peoples collective right to life: a lacuna in international human rights framework? The context, the need, the struggle
Creators: name: Skwarska, Beata
Publisher: name: My University
Year: 2006
Subjects: indigenous peoples
IWGIA
right to life
United Nations Declaration on the Rights of Indigenous Peoples

description: Second semester University: University of Seville.
description: The thesis deals with threats to indigenous peoples’ survival or rather their right to life and its protection in the international human rights framework by a number of instruments and mechanisms - these existing and those still in the making, with the emphasis on life’s collective nature, its multiple dimensions, and protective measures’ legal character. The threats the protection against which is gauged in the course of the work are those due to outside and often deliberate forces, decisions and policies and are related to, inter alia, armed conflicts, violence or globalization-related factors; survival is understood comprehensively as both physical and cultural or ethnic. First of all, it is the intension of the thesis to assess if the existing normative and procedural framework –specifically, genocide prohibition regime and UN treaty bodies-based protection of the right to culture – is sufficient to address the exigencies of contemporary existence of indigenous peoples or whether there exists a lacuna to be filled in this regard. Following this assessment, the ongoing process of addressing the need identified by indigenous peoples themselves ispresented, i.e. their struggle to have appropriate provisions included in the Declaration on the Rights of Indigenous Peoples. It is all the more relevant now given that this text’s only remaining step in the United Nations’ structure before becoming a universal instrument is the adoption by the General Assembly, possibly this year, if viewed against the Recommendation by the Human Rights Council and the commitment reaffirmed by Heads of State and Government at 2005 World Summit and the General Assembly Resolution 60/1, paragraph 127 “to continue making progress in the advancement of the human rights of the world’s indigenous peoples at the local, national, regional and international levels, including through consultation and collaboration with them, and to present for adoption a final draft United Nations declaration on the rights of indigenous peoples as soon as possible.”
Supplementary document for Liquid crystal-based fiber laser sensor for noninvasive gas detection - 6531782.pdf
Creators: name: Zhou, Dong
name: Wang, Qingxiu
name: Lan, Zeqing
name: chen, yuzhou
name: Peng, Zenghui
name: Zhang, Lingli
name: liu, yongjun
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement.
Complexities Study Protocol -Supplemental material for Improving spatial decision making using interactive maps: An empirical study on interface complexity and decision complexity in the North American hazardous waste trade
Creators: name: Vincent, Kristen
name: Roth, Robert E
name: Moore, Sarah A
name: Qunying Huang
name: Lally, Nick
name: Sack, Carl M
name: Nost, Eric
name: Rosenfeld, Heather
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: Geography
subject: 120599 Urban and Regional Planning not elsewhere classified
subject: FOS: Social and economic geography

description: Supplemental material, Complexities Study Protocol for Improving spatial decision making using interactive maps: An empirical study on interface complexity and decision complexity in the North American hazardous waste trade by Kristen Vincent, Robert E Roth, Sarah A Moore, Qunying Huang, Nick Lally, Carl M Sack, Eric Nost and Heather Rosenfeld in Environment and Planning B: Urban Analytics and City Science
Dynamique de type Collatz en base b ≥ 2 : convergence terminale et absence de cycles parfaits (Collatz-like Dynamics in Base b ≥ 2: Terminal Convergence and Absence of Perfect Cycles)
Creators: name: Hassanine, Sam
Publisher: name: Zenodo
Year: 2025

description: Ce travail étend une dynamique numérique inspirée de la conjecture de Collatz à toute base entière b ≥ 2, en définissant une fonction h_b opérant chiffre par chiffre sur la représentation des entiers. Il est démontré que toute trajectoire finit inévitablement par produire un chiffre terminal nul, entraînant une division par b et une réduction de la hauteur. Ce comportement exclut l'existence de cycles parfaits à hauteur constante et révèle une convergence universelle vers un cycle attracteur. La preuve repose sur des arguments combinatoires et une analyse de la dynamique dans des espaces finis.

This article extends an iterative dynamic inspired by the Collatz conjecture to all integer bases b ≥ 2, defining a function h_b that operates digit by digit on integer representations. It is proven that every trajectory inevitably produces a terminal zero digit, triggering division by b and reducing the numerical height. This behavior excludes the existence of perfect cycles with constant height and reveals a universal convergence toward an attractor cycle. The proof relies on combinatorial arguments and an analysis of the dynamics within finite symbolic spaces.
Opportunities For Chemical Protein Mimics In Vaccine Design
Creators: name: R. Liskamp
Publisher: name: Zenodo
Year: 2016

description: Increasingly (chemo)synthesis is very competitive with biosynthesis for obtaining relatively large molecular constructs of for example large peptides and even proteins.One of the undisputable very strong points of chemosynthesis is the ability to introduce structural modifications which cannot be realized using biotechnological approaches such as the introduction of D-amino acids or multiple different non-proteinogenic amino acids. This development offers great opportunities and is very promising for embarking on molecular approaches for design and development of modified proteins and protein mimics. Synthetic protein mimics capable of mimicry of protein surfaces may provide an entry into synthetic vaccines or mimics of antibodies.We have addressed the great challenge of construction of protein mimics consisting of different peptide segments corresponding to different sites on the surface of a protein by molecular scaffolding of (cyclic) peptides. The molecular scaffolds we have developed enable mimicry of discontinuous epitopes of proteins of pathogens. In addition a carrier protein or for example a Toll-like receptor ligand can be incorporated. Vaccination with a protein mimic obtained by molecular scaffolding showed protection against pertussis.
Indigenous peoples right to land: international standards and possible developments. The cultural value of land and the link with the protection of the environment. The perspective in the case of Mapuche-Pehuenche
Creators: name: Nesti, Lorenzo
Publisher: name: My University
Year: 1999
Subjects: indigenous peoples
land tenure
Mapuche
peoples rights

description: Second semester University: University of Deusto, Bilbao
white_online_appendix – Supplemental material for Are Children Perceived to Be Morally Exceptional? Different Sets of Psychological Variables Predict Adults’ Moral Judgments About Adults and Young Children
Creators: name: Cindel J. M. White
name: Schaller, Mark
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, white_online_appendix for Are Children Perceived to Be Morally Exceptional? Different Sets of Psychological Variables Predict Adults’ Moral Judgments About Adults and Young Children by Cindel J. M. White and Mark Schaller in Personality and Social Psychology Bulletin
MMS761789_Supplemental_material – Supplemental material for Computation of elastic equilibria of complete Möbius bands and their stability
Creators: name: Moore, Alexander
name: Healey, Timothy
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies

description: Supplemental material, MMS761789_Supplemental_material for Computation of elastic equilibria of complete Möbius bands and their stability by Alexander Moore and Timothy Healey in Mathematics and Mechanics of Solids
HAND769378_Appendix – Supplemental material for Outcomes of Surgical Management for Thumb Basilar Arthritis in Patients 55 Years of Age and Younger
Creators: name: Rhee, Peter C.
name: Paul, Aaron
name: Carlsen, Brian
name: Shin, Alexander Y.
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: Medicine
subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences

description: Supplemental material, HAND769378_Appendix for Outcomes of Surgical Management for Thumb Basilar Arthritis in Patients 55 Years of Age and Younger by Peter C. Rhee, Aaron Paul, Brian Carlsen, and Alexander Y. Shin in HAND
Privacy_in_Mediated_and_Nonmediated_Communication_Sample_Description – Supplemental material for Privacy in Mediated and Nonmediated Interpersonal Communication: How Subjective Concepts and Situational Perceptions Influence Behaviors
Creators: name: Teutsch, Doris
name: Masur, Philipp K.
name: Trepte, Sabine
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications

description: Supplemental material, Privacy_in_Mediated_and_Nonmediated_Communication_Sample_Description for Privacy in Mediated and Nonmediated Interpersonal Communication: How Subjective Concepts and Situational Perceptions Influence Behaviors by Doris Teutsch, Philipp K. Masur and Sabine Trepte in Social Media + Society
Supplementary document for Highly-Cascaded First-order Sapphire Optical Fiber Bragg Gratings Fabricated by Femtosecond Laser - 6532582.pdf
Creators: name: Mumtaz, Farhan
name: Tekle, Hanok
name: Zhang, Bohong
name: Smith, Jeffrey D.
name: OMALLEY, RONALD J.
name: Huang, Jie
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement 1
Brain-Shuttle - Bace1 Peptide Inhibitor Conjugates Lower Brain A? Levels
Creators: name: E. Kitas
Publisher: name: Zenodo
Year: 2016

description: Therapeutic approaches to fight Alzheimer's Disease include anti-A? peptide antibodies and secretase inhibitors or modulators and aim to either prevent or reduce amyloidosis. Secretase inhibitors are considered to reduce the de novo production of A?, but efficiency is limited due to restricted passage of therapeutic molecules over the blood-brain barrier (BBB). The Brain Shuttle (BS) technology based on Transferrin Receptor (TfR)-mediated transport is capable of shuttling large molecules over the BBB into the brain. We designed BACE1 specific peptide inhibitors with varying lipid terminal modifications, and ligated them to the BS via a sortase linker. A 1.82? resolution crystal structure of BACE1 ectodomain in complex with a dual, ortho-exosite peptide inhibitor shows that this compound binds with both arms to the same protein. We performed a study comparing these BACE1 inhibitor peptides in vivo. BACE1 inhibition led to a significant time- and dose-dependent decrease in plasma A?, and only after ligating the inhibitory peptides to the BS, to a significant decrease in brain A? levels. BACE1 inhibition over time was most significant in brain and plasma if the molecule contained a palmitylated terminus. Changing the terminus to cholesterol reduced the BACE1 inhibitor peptide efficacy in vivo, even though in vitro gathered cell IC50 data suggested otherwise. A lipid-free BS-BACE1 inhibitor conjugate also led to a 40% A? decrease in brain levels at 24 hrs in wt mice. Our results demonstrate that the BS is key for brain exposure following systemic administration and paves the way for BACE1 peptide inhibitors with optimized pharmacophores to achieve superior potency and selectivity.
A Chemical Space Approach To Discover Novel Antimicrobial Peptides
Creators: name: J.-L. Reymond
Publisher: name: Zenodo
Year: 2016

description: The ?Chemical space? describes the ensemble of all possible chemical compounds, in particular those of interest as drugs for medical use, spanning from small organic molecules such as aspirin to large proteins such as antibodies. The concept of chemical space calls for considering every possible molecule beyond those already known.[1] We recently started to design cheminformatic tools to describe the chemical space of peptides and proteins using 3D-pharmacophores and molecular shape.[2] We have now expanded this computational approach to explore the chemical space of topologically diverse, multi-branched peptides such as peptide dendrimers[3] and polycyclic peptides.[4] Here I present our initial results in using the method to discover novel bicyclic peptides with antimicrobial activities. These novel bicyclic antimicrobial peptides (bcAMPs) efficiently target multidrug resistant P. aeruginosa and P. aeruginosa biofilms while showing low hemolysis activity and high serum stability.
References:
1. Reymond, J. L. The Chemical Space Project. Acc. Chem. Res. 2015, 48, 722-730.
2. Jin, X.; Awale, M.; Zasso, M.; Kostro, D.; Patiny, L.; Reymond, J. L. Pdb-Explorer: A Web-Based Interactive Map of the Protein Data Bank in Shape Space. BMC Bioinformatics 2015, 16, 339.
3. Stach, M.; Siriwardena, T. N.; Kohler, T.; van Delden, C.; Darbre, T.; Reymond, J. L. Combining Topology and Sequence Design for the Discovery of Potent Antimicrobial Peptide Dendrimers against Multidrug-Resistant Pseudomonas Aeruginosa. Angew. Chem., Int. Ed. 2014, 53, 12827-12831.
4. Bartoloni, M.; Jin, X.; Marcaida, M. J.; Banha, J.; Dibonaventura, I.; Bongoni, S.; Bartho, K.; Grabner, O.; Sefkow, M.; Darbre, T.; Reymond, J.-L. Bridged Bicyclic Peptides as Potential Drug Scaffolds: Synthesis, Structure, Protein Binding and Stability. Chemical Science 2015, 6, 5473-5490.