cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Characterizing the cellular diversity and molecular signatures within the hair follicle dermal stem cell lineage
Creators: name: Hagner, Andrew
Publisher: name: Graduate Studies
Year: 2017
Subjects: subject: Bioinformatics
subject: FOS: Computer and information sciences
subject: Biology--Cell
subject: Genetics
subject: FOS: Biological sciences
subject: Biology--Molecular
subject: Veterinary Science
subject: DERMAL STEM CELL
subject: Hair Follicle
subject: DERMAL PAPILLA
subject: REGENERATION
subject: SELF-RENEWAL
subject: FIBROBLAST
subject: RNA-SEQUENCING
subject: DERMAL SHEATH
subject: MESENCHYME

description: Mammalian skin is capable of tissue repair upon injury, but is unable to perform true, scarless regeneration in all but the most superficial of injuries. Consequently, many injuries form scar tissue, an excessive deposition of cross-linked collagen that suffers from poor elasticity, reduced resistance to ultraviolet radiation, and an absence of hair and sweat glands that regulate skin function. Fibroblasts, the progeny of mesenchymal stem cells of the dermis, are the source of scar tissue. Fibroblasts themselves are essential for the proper function of many tissues in the body, particularly in a supportive role for all epithelia, such as the skin, lung and intestine (Di Wang et al., 2010). The dysfunction of skin fibroblasts is of particular clinical importance to problems with wound healing, fibrosis, hair loss, and skin aging. Fibroblasts are a highly plastic cell type, capable of a wide array of functions, yet we have only begun to appreciate their diversity (Driskell et al., 2013). Furthermore, we have only recently discovered the existence of a hair follicle-associated dermal stem cell (hfDSC), and a comprehensive characterization of hfDSCs and their progeny is lacking (Rahmani et al., 2014). To explore tissue regeneration and perhaps develop new wound-healing strategies, an understanding of the molecular signaling governing adult dermal fibroblast behavior must be achieved, so that fibroblast behavior can be coopted or controlled. This thesis is therefore concerned with developing a strategy to specifically isolate adult hfDSCs and their progeny, to discern which molecular controls are involved in generating different types of skin fibroblasts, and to investigate the reciprocal signaling used by mesenchymal cells to modulate epithelial cell function during regeneration. Using a novel FACS strategy to isolate adult hfDSCs/progeny from adult skin at the onset of HF regeneration, I performed RNA-seq to establish gene expression signatures for specialized fibroblasts of the HF, and tested Rspo2/3, Grem2 and Hic1, signature genes that I found to control fibroblast function. Taken together, my research identifies unique transcriptional programs that underlie the functional heterogeneity amongst specialized fibroblasts within the adult hair follicle, and furthers our understanding of mesenchymal cell contribution to tissue regeneration.
Dark Matter from the Inflaton Field
Creators: name: de la Macorra, A.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We present a model where inflation and Dark Matter takes place via a single scalar field phi. Without introducing any new parameters we are able unify inflation and Dark Matter using a scalar field phi that accounts for inflation at an early epoch while it gives a Dark Matter WIMP particle at low energies. After inflation our universe must be reheated and we must have a long period of radiation dominated before the epoch of Dark Matter. Typically the inflaton decays while it oscillates around the minimum of its potential. If the inflaton decay is not complete or sufficient then the remaining energy density of the inflaton after reheating must be fine tuned to give the correct amount of Dark Matter. An essential feature here, is that Dark Matter-Inflaton particle is produced at low energies without fine tuning or new parameters. This process uses the same coupling g as for the inflaton decay. Once the field phi becomes non-relativistic it will decouple as any WIMP particle, since n_phi is exponentially suppressed. The correct amount of Dark Matter determines the cross section and we have a constraint between the coupling $g$ and the mass $m_o$ of phi. The unification scheme we present here has four free parameters, two for the scalar potential V(phi) given by the inflation parameter lambda of the quartic term and the mass m_o. The other two parameters are the coupling $g$ between the inflaton phi and a scalar filed varphi and the coupling h between varphi with standard model particles psi or chi. These four parameters are already present in models of inflation and reheating process, without considering Dark Matter. Therefore, our unification scheme does not increase the number of parameters and it accomplishes the desired unification between the inflaton and Dark Matter for free.
description: 9 pages, 3 figures. arXiv admin note: substantial text overlap with arXiv:0911.5172
The Jewish Dog and 'Shehitah'
Creators: name: Stow, Kenneth
Publisher: name: Interfaces: A Journal of Medieval European Literatures
Year: 2019
Subjects: subject: Meat; Purity; Slaughter; Biophilia; Tranquillo Corcos
subject: Jewish-Christian Interaction

description: The essential clash between Judaism and Christianity, especially Catholic Christianity, has been over purity and contamination, in particular, by touch. The anxiety is biblically derived. It pertains especially to consuming meat and is amplified by the biophilic 'affiliation' of humans with animals. The current debate over kosher and halal slaughtering carries over these anxieties. That debate is exemplified in the article by the prohibition of Christian butchers purchasing and selling non-kosher quarters of meat in the early eighteenth century Roman Ghetto and the fight against this prohibition waged by Rabbi Tranquillo Corcos.
description: Interfaces: A Journal of Medieval European Literatures, N. 5 (2018): Biblical Creatures: The Animal as an Object of Interpretation in Pre-Modern Christian and Jewish Hermeneutic Traditions
Mithraculus forceps A. Milne Edwards 1875
Creators: name: Almeida, Alexandre Oliveira De
name: Guerrazzi, Maria Cec Lia
name: Coelho, Petr Ȏ Nio Alves
Publisher: name: Zenodo
Year: 2007
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Mithracidae
Mithraculus
Mithraculus forceps

description: Mithraculus forceps (A. Milne Edwards, 1875)
Material examined (N=2). 1m, 12/VI/2004, St. 0 1 (MZUESC #681).
Distribution. Western Atlantic – from North Carolina to southern Florida, Gulf of Mexico, Antilles, Venezuela, and Brazil (Fernando de Noronha, and from Maranhão to São Paulo) (Melo 1996). St. Paul’s Rocks (Holthuis et al. 1980). Brazil – Santa Catarina (Rieger & Giraldi 1996).
Ecological notes. On hard bottoms, also on sand, coral, or algae, or associated with sponges. Shallow waters to 90 m (Melo 1996).
Previous records in Bahia. Miers (1886) (as Mithrax forceps), Moreira (1901) (as Mithrax forceps), Rathbun (1925) (as Mithrax (Mithraculus) forceps), Coelho (1971) (as Mithrax (Mithraculus) forceps), Coelho & Ramos (1972) (as Mithrax (Mithraculus) forceps), Melo (1985) (as Mithrax (Mithraculus) forceps), Gouvêa (1986a) (as Mithrax forceps), Coelho & Torres (1990), Barreto et al. (1993).
description: Published as part of Almeida, Alexandre Oliveira De, Guerrazzi, Maria Cec Lia & Coelho, Petr Ȏ Nio Alves, 2007, Stomatopod and decapod crustaceans from Camamu Bay, state of Bahia, Brazil, pp. 1-45 in Zootaxa 1553 on page 28, DOI: 10.5281/zenodo.178168
On the velocity of the Biot slow wave in a porous medium: Uniform asymptotic expansion
Creators: name: Edelman, Inna
Publisher: name: Weierstrass Institute
Year: 2002
Subjects: subject: Porous media
subject: bulk waves
subject: asymptotics
subject: bifurcation
subject: 35C20
subject: 35L45
subject: 74F10
subject: 74J10
subject: 76M45

description: Asymptotic behavior of the Biot slow wave is investigated. Formulae for short- and long-wave approximations of phase velocity of the P2 wave are presented. These asymptotic expansions are compared with exact solution, constructed numerically. It is shown that both expansions fit very well the real velocity of the P2 mode. Procedure for matching of short- and long-wave asymptotic expansions is suggested.
Studying Alumni Social Network by Data Collection, Cleaning and Analysis from Social Media
Creators: name: Karakira, Ibrahim
Publisher: name: Graduate Studies
Year: 2017
Subjects: subject: Computer Science
subject: Alumni
subject: Social Network Analysis
subject: SNA

description: Individuals that have graduated from an educational institution become so-called alumni of the institution. The institution then tries to stay in contact with the alumni for two main purposes. It is important to facilitate continued communication between different members of the alumni and to use those connections to elicit donations. Thus, an alumni organization is formed to fulfill those purposes. This organization is led by a board that is mainly formed of alumni volunteers. The institution provides an office on campus with office staff to aid the alumni organization and help in running it. The aim of this thesis is to view the alumni organization through the lens of social network where the nodes of the network are the alumni and the links being the social connections that are identified from a specially designed survey, social network sites and other sources of information. This network is analyzed to identify the most important actors in the network, the nodes closest to all other nodes, and other necessary measures elicited from the network. This information might help inform the alumni office in assessing their efforts while arranging alumni events to improve the social adhesions of the alumni. The results present some interesting data that will be shared with the Alumni Office. The resulting data might help the Alumni Office in their planning for future events.
Studies on the roles of human ferroportin and hephaestin in iron homeostasis
Creators: name: Wong, Ann Yuen Kwan
Publisher: name: University of British Columbia
Year: 2010

description: Ferroportin-1 (Fpn1) is a highly conserved 571-amino acid protein with the human, mouse, and rat polypeptides having 90–95% sequence identity at the amino acid level. Disruption of Fpn1 expression in zebrafish and mice results in embryonic lethality, while conditional knockout of the gene encoding Fpn1 in the intestine at the postnatal stage leads to severe iron deficiency anemia and iron accumulation in duodenal enterocytes. These studies suggest that Fpn1 is the major, if not the sole, exporter protein for iron. Export of dietary iron is thought to be facilitated by hephaestin (Hpn), a multicopper ferroxidase in the basolateral membrane of duodenal enterocytes. However, the precise mechanism of iron transport by Fpn1 and Hpn remains to be elucidated. The absence of an iron export mechanism in Saccharomyces cerevisiae was utilized to explore how Fpn1 and Hpn function in iron export. Unlike humans, S. cerevisiae transports excess iron into a storage vacuole through the vacuolar iron transporter, Ccc1p. The Δccc1 mutant fails to store excess iron; as a result, iron accumulates in the cytosol and cells die due to oxidative stress when exposed to high concentrations of extracellular iron. By expressing recombinant human Fpn1 and Hpn in S. cerevisiae, an iron export system was introduced. The functionality of rhHpn in S. cerevisiae was confirmed by both a ferrozine ferroxidase assay and a transferrin iron-loading assay. The effects of the individual or both recombinant proteins on iron sensitivity of the Δccc1 yeast with an additional fet3 (the yeast homolog of Hpn) deletion were evaluated. Recombinant human Fpn1 and Hpn suppressed the lethal phenotype of the Δccc1 mutant while co-expression of rhHpn with rhFpn1 led to a stronger rescue phenotype of the Δccc1 mutant under concentrations of high extracellular iron. The expression of rhFpn1 and / or rhHpn also relieved the copper sensitive Δfet3 mutant from copper stress. A physical interaction between rhFpn1 and rhHpn was demonstrated by cross-linking with BS³. These studies advance our knowledge of the roles Fpn1 and Hpn play in human enterocytes and suggest that these proteins are intimately involved in iron export from enterocytes into the blood.
The Harry Potter phenomenon and its implications for literacy education
Creators: name: Novosel, Jadranka
Publisher: name: University of British Columbia
Year: 2010

description: According to Nielsen BookScan, an independent book trade monitoring service, 2,652,656 copies of the final book in the Harry Potter series, Harry Potter and the Deathly Hallows (Rowling, 2007), were sold across the United Kingdom within the first 24 hours of sales. The book thus became the fastest selling in history, in doing so overtaking the sales record of its predecessor, Harry Potter and the Half-Blood Prince (Rowling, 2005), which sold 2,009,574 copies in the UK in the first 24 hours. With yearly releases beginning in 1997, at one point Harry Potter novels occupied the top four spots on The New York Times Bestseller List, prompting the addition of a children’s bestseller list so popular literary fiction intended for adults might be represented. Considering this scenario, questions that arise for literary educators are as follows: What forces were at play behind this literary phenomenon and what are the implications for literacy and literary education? This thesis examines the success of Harry Potter as a literary and commercial phenomenon, considering in particular the literary features of the novels that might have contributed to their success, the marketing of the texts and the rise of the Harry Potter "brand," the timing of the emergence of the series alongside the rise of social media, and the implications of all of this for the future of literary reading and literary education.
Post-Double Hopf Bifurcation Dynamics and Adaptive Synchronization of a Hyperchaotic System
Creators: name: Gambino, Gaetana
name: Choudhury, Sudipto R.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: Dynamical Systems (math.DS)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: In this paper a four-dimensional hyperchaotic system with only one equilibrium is considered and its double Hopf bifurcations are investigated. The general post-bifurcation and stability analysis are carried out using the normal form of the system obtained via the method of multiple scales. The dynamics of the orbits predicted through the normal form comprises possible regimes of periodic solutions, two-period tori, and three-period tori in parameter space. Moreover, we show how the hyperchaotic synchronization of this system can be realized via an adaptive control scheme. Numerical simulations are included to show the effectiveness of the designed control.
Additional file 1 of Recognising and responding to acute deterioration in care home residents: a scoping review
Creators: name: Hodge, Sevim Y.
name: Ali, Mohammad R.
name: Hui, Ada
name: Logan, Pip
name: Gordon, Adam L.
Publisher: name: figshare
Year: 2023
Subjects: Biotechnology
Science Policy

description: Additional file 1: Appendix I.
Biblical Creatures: The Animal as an Object of Interpretation in Pre-Modern Christian and Jewish Hermeneutic Traditions
Creators: name: Lembke, Astrid
name: Trînca, Beatrice
name: Koch, Elke
name: Weitbrecht, Julia
name: Rotman, David
name: Traulsen, Johannes
name: Roman, Oren
name: Kraß, Andreas
name: Offenberg, Sara
name: Roling, Bernd
name: Stow, Kenneth
Publisher: name: Interfaces: A Journal of Medieval European Literatures
Year: 2019
Subjects: Europe; Middle Ages; Comparative Literature; Animal Studies; Theology; Typology; Allegory

description: This issue of Interfaces explores the question of how Jewish and Christian authors in pre-modern Latin Europe thought and wrote about some of the animals mentioned in the Bible. To them, thinking about animals was a way of thinking about what it means to be human, to perceive the world, and to worship God and his creation. Animals' nature, animals' actions and animals' virtues or shortcomings were used as symbols and metaphors for describing human behavior, human desires, human abilities and disabilities, and positive or negative inclinations or traits of character.
Both Christian and Jewish medieval and early modern scholars wondered about how they could possibly delve into the deeper layers of meaning they assumed any textual or extra-textual animal to convey. Not surprisingly, they often had to deal with the fact that a specific animal was of interest to members of both religious communities. A comparison between Jewish and Christian ways of reading and interpreting biblical passages featuring animals shows what the two hermeneutic traditions had in common, what separated them, and how they influenced each other, depending on the historical context in which the authors worked.
The papers in this issue of Interfaces cover a wide range of animal species, such as the dove, the stag, the unicorn, the elephant, the crocodile, the lion, the hyena, the raven, the hare, and the dog as medieval and early modern authors and illuminators portrayed and interpreted them. Since several themes come up in more than one paper concerning different kinds of animals, this issue groups its papers in three sections. These sections deal with divine creatures (mediators between humankind and God, symbols for the human believer, agents of heaven); exotic creatures (animals in different parts of the world, encounters between humans and animals in past times, animals with extraordinary appearances and properties); and social creatures (transgressive and pious animals, animals used to demonstrate obedience or to facilitate transgression, animals as symbols for conflict or cooperation).
description: Interfaces: A Journal of Medieval European Literatures, N. 5 (2018): Biblical Creatures: The Animal as an Object of Interpretation in Pre-Modern Christian and Jewish Hermeneutic Traditions
The Animal as an Object of Interpretation in Pre-Modern Christian and Jewish Hermeneutic Traditions – an Introduction
Creators: name: Lembke, Astrid
Publisher: name: Interfaces: A Journal of Medieval European Literatures
Year: 2019
Subjects: Europe; Middle Ages; Comparative Literature; Animal Studies; Theology; Typology; Allegory

description: Guest editor Astrid Lembke introduces Issue No. 5 of Interfaces: A Journal of Medieval European Literatures, dedicated to "Biblical Creatures: The Animal as an Object of Interpretation in Pre-Modern Christian and Jewish Hermeneutic Traditions," and offers a general overview of the matter and contents of the contributions.
description: Interfaces: A Journal of Medieval European Literatures, N. 5 (2018): Biblical Creatures: The Animal as an Object of Interpretation in Pre-Modern Christian and Jewish Hermeneutic Traditions
Big-Box Retail Development: Examining Complications, Understanding Trends, and Introducing Holistic Strategies to Minimize the Impacts on Communities
Creators: name: Radmehr, Shirin
Publisher: name: Environmental Design
Year: 2015
Subjects: subject: Architecture
subject: FOS: Civil engineering
subject: Big-box
subject: Human Scale
subject: Holism
subject: Community
subject: Character
subject: Safety
subject: Integration
subject: Sustainability
subject: Urban Image
subject: Sense of Plcae
subject: Environment

description: Big-box stores are large-scale, single storey buildings such as Wal-Mart, Home Depot, Canadian Tire, and Rona, to name a few. These types of projects have been present in North American cities for decades and have offered one-stop shopping experiences and lower prices than smaller, independent stores. However, big-box stores, at times, also present social, cultural, and environmental issues. This thesis explores the development of big-box retailers and examines their contribution to public space within the urban design context through the lens of a holistic approach. Using holistic guidelines, big-box buildings are critically analyzed in order to reconceive a design that is functional, environmentally sustainable, and aesthetically appealing. An integrated design framework is then developed that offers strategies to manage the complex issues of big-box retail and development. It also provides holistic solutions for sustainable design, while promoting a sense of place and increasing the potential for an attachment to place.
Additional file 2 of Recognising and responding to acute deterioration in care home residents: a scoping review
Creators: name: Hodge, Sevim Y.
name: Ali, Mohammad R.
name: Hui, Ada
name: Logan, Pip
name: Gordon, Adam L.
Publisher: name: figshare
Year: 2023
Subjects: Biotechnology
Science Policy

description: Additional file 2: Appendix II.
Characterizing Abelian Varieties by the Reductions of the Mordell-Weil Group
Creators: name: Hall, Chris
name: Perucca, Antonella
Publisher: name: arXiv
Year: 2011
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11G10

description: Let $A$ be an abelian variety defined over a number field $K$. If $\mathfrak{p}$ is a prime of $K$ of good reduction for $A$, let $A(K)_\mathfrak{p}$ denote the image of the Mordell-Weil group via reduction modulo $\mathfrak{p}$. We prove in particular that the size of $A(K)_\mathfrak{p}$, by varying $\mathfrak{p}$, encodes enough information to determine the $K$-isogeny class of $A$, provided that the following necessary condition is satisfied: $B(K)$ has positive rank for every non-trivial abelian subvariety $B$ of $A$. This is the analogue to a result by Faltings of 1983 considering instead the Hasse-Weil zeta function of the special fibers $A_\mathfrak{p}$.
Herzberg Circuit and Berry's Phase in Chirality-based Coded Qubit in a Triangular Triple Quantum Dot
Creators: name: Hsieh, Chang-Yu
name: Rene, Alexandre
name: Hawrylak, Pawel
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We present a theoretical proposal for the Herzberg circuit and controlled accumulation of Berry's phase in a chirality-based coded qubit in a triangular triple quantum dot molecule with one electron spin each. The qubit is encoded in the two degenerate states of a three spin complex with total spin $S=1/2$. Using a Hubbard and Heisenberg model the Herzberg circuit encircling the degeneracy point is realized by adiabatically tuning the successive on-site energies of quantum dots and tunnel couplings across a pair of neighbouring dots. It is explicitly shown that encircling the degeneracy point leads to the accumulation of the geometrical Berrys phase. We show that only triangular but not linear quantum dot molecule allows for the generation of Berry's phase and we discuss a protocol to detect this geometrical phase.
The Bride and the Wounds − "columba mea in foraminibus petrae" (Ct. 2.14)
Creators: name: Trînca, Beatrice
Publisher: name: Interfaces: A Journal of Medieval European Literatures
Year: 2019
Subjects: Song of Songs; Passion Piety; Mysticism; Dove; Anatomy

description: The dove – as a term of endearment from the Song of Songs – constitutes a subtle recurring sign throughout a medieval mystical tradition that links it to Christ's wounds and therefore to human anatomy, as well as to the poetic traditions of courtly love.
description: Interfaces: A Journal of Medieval European Literatures, N. 5 (2018): Biblical Creatures: The Animal as an Object of Interpretation in Pre-Modern Christian and Jewish Hermeneutic Traditions
Some considerations about NS5 and LST Hawking radiation
Creators: name: Lorente-Espín, Oscar
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We have studied the Hawking radiation corresponding to the NS5 and Little String Theory (LST) black hole models using two semi-classical methods: the complex path method and a gravitational anomaly. After summarizing some known concepts about the thermodynamics of these theories, we have computed the emission rates for the two black hole models. The temperature calculated from, e.g. the well-known surface gravity expression, is shown to be identical to that obtained from both the computation of the gravitational anomaly and the complex path method. Moreover, the two semi-classical methods show that NS5 exhibits non-thermal behavior that contrasts with the thermal behavior of LST. We remark that energy conservation is the key factor leading to a non-thermal profile for NS5. In contrast, LST keeps a thermal profile even when energy conservation is considered because temperature in this model does not depend on energy.
description: 18 pages, acknowledgments included, some concepts clarified, typos corrected, journal reference included
A Staggering Vision: The Mediating Animal in the Textual Tradition of Saint Eustachius
Creators: name: Koch, Elke
Publisher: name: Interfaces: A Journal of Medieval European Literatures
Year: 2019
Subjects: subject: Hagiography; Eustachius (Eustathius); Placidas; Stag; Iconoclasm; Conversion
subject: Medieval Latin and Byzantine hagiography

description: The paper concentrates on the story of St. Eustachius and discusses the famous episode in which the protagonist is led to conversion through an epiphanic encounter with a stag. This episode, known as Eustachius' vision, highlights the semiotic polyvalence of the animal mediating between God and human. The paper analyses the discourse on animals in the vulgate version of the passion of Eustachius. It shows how the representation of the stag differs between redactions of the story, outlines the alternative readings of the vision episode suggested by this textual variance, and points out their relation to different contexts.
description: Interfaces: A Journal of Medieval European Literatures, N. 5 (2018): Biblical Creatures: The Animal as an Object of Interpretation in Pre-Modern Christian and Jewish Hermeneutic Traditions
“Thou hast heard me from the horns of the unicorns:” The Biblical Unicorn in Late Medieval Religious Interpretation
Creators: name: Weitbrecht, Julia
Publisher: name: Interfaces: A Journal of Medieval European Literatures
Year: 2019
Subjects: subject: Unicorn; Allegorical Hunt of the Unicorn; Annunciation; Beschlossen gart des Rosenkrantz Marie; Human-Animal Relationships
subject: P

description: This article investigates the 'allegorical hunt of the unicorn' in late medieval visual and narrative art. The existence of the unicorn in biblical lore is an important factor in how the unicorn has been integrated into Christian symbolism. By expanding the narrative connection between hunting, virginity, and taming provided by Physiologus, the allegorical interpretations turn the taming of the wild unicorn into signifying the incarnation of Christ. This influential interpretation enables an overlaying of allegorical meanings in various media. In this process, knowledge is organized into clusters of meaning in which the creature functions as a dynamic reservoir of knowledge. This perspective allows for a deeper understanding of the functions of animals (or more specifically, human-animal relations) in medieval Christian interpretation.
description: Interfaces: A Journal of Medieval European Literatures, N. 5 (2018): Biblical Creatures: The Animal as an Object of Interpretation in Pre-Modern Christian and Jewish Hermeneutic Traditions
Textual Animals Turned into Narrative Fantasies: The Imaginative Middle Ages
Creators: name: Rotman, David
Publisher: name: Interfaces: A Journal of Medieval European Literatures
Year: 2019
Subjects: subject: Marvelous; Jewish Folklore; Aggadah; Folk-Narratives; Space in Literature
subject: PJ5001-5060 Hebrew Literature

description: This article focuses on the concept 'reconstruction of the world' proposed by G. Zoran in his theoretical work on the representation of space in narrative. It makes special reference to the inter-medially transformative processes that narrators and audiences undergo, as materially concrete objects in space turn into representations in the verbal medium. Investigating the possible bodies of knowledge common to the participants in the communicative process, the article specifically discusses animals widely described in late antique and medieval Jewish folk tales and considers the possibilities for reconstructing the sources of shared imaginary worlds.
description: Interfaces: A Journal of Medieval European Literatures, N. 5 (2018): Biblical Creatures: The Animal as an Object of Interpretation in Pre-Modern Christian and Jewish Hermeneutic Traditions
DNA methylation at imprinted and non-imprinted genes in the sperm of men affected by severe male factor infertility
Creators: name: Minor, Agata
Publisher: name: University of British Columbia
Year: 2010

description: Abnormal DNA methylation at imprinted and non-imprinted genes has been associated with spermatogenesis failure. However, little information is available regarding DNA methylation at those genes in men affected by severe male factor infertility. We hypothesized a higher incidence of aberrant DNA methylation would be present in the ejaculate and testicular sperm of men affected by severe male factor infertility compared to that in fertile control men. Furthermore, we hypothesized abnormal DNA methylation would also affect non-imprinted genes in the sperm of men affected by severe oligozoospermia. DNA methylation at the differentially methylated regions (DMRs) of imprinted genes, H19, IG-GTL2 and MEST, was studied in the ejaculate sperm of men affected by severe and very severe oligozoospermia, in the testicular sperm of men affected by obstructive azoospermia (OA) and non-obstructive azoospermia (NOA), and having undergone vasectomy reversal. The results were compared to that in the sperm of control men of proven fertility. Methylation at the DMRs was evaluated by bisulphite sequencing of multiple unique clones, representative of single sperm. DNA methylation was also studied at non-imprinted genes in sperm of men affected by severe and very severe oligozoospermia. DNA methylation was analyzed at 1,505 CpG sites using the Illumina GoldenGate methylation Cancer Panel I with the results at selected CpG sites being confirmed using pyrosequencing. We found the H19 DMR to be most susceptible to methylation abnormalities and the IG-GTL2 DMR to be the most robust. We found a higher incidence of aberrant DNA methylation in the sperm of men affected by severe oligozoospermia, OA and in men undergoing vasectomy reversal compared to control men. The presence of aberrant imprinting in men with obstruction suggests that abnormal methylation at imprinted genes may not only be related to spermatogenesis failure, as seen in patients affected by severe oligozoospermia, but also to changes in testicular environment that may occur in response to obstruction. Lastly, our analysis of a limited number of samples suggests that abnormal DNA methylation in the sperm of men affected by severe oligozoospermia may also affect non-imprinted genes. Our results warrant further analysis of a larger sample size.
Investigating dispersal through molecular genomics: Sex-biased dispersal and phylogeography in aye-ayes (Daubentonia madagascariensis) in Madagascar
Creators: name: Aylward, Megan L.
Publisher: name: Graduate Studies
Year: 2017
Subjects: subject: Anthropology
subject: FOS: Sociology
subject: Genomics
subject: Genetics
subject: FOS: Biological sciences
subject: Aye-aye
subject: Lemur
subject: Madagascar
subject: Dispersal
subject: Phylogeography
subject: eDNA
subject: next-generation

description: Dispersal patterns within species have profound consequences for population dynamics and species’ evolutionary trajectories. Intraspecific interactions and habitat variability dictate dispersal trends. Given the rate at which habitat is altered globally by climatic and anthropogenic influences, it is important to understand historic dispersal trends to assess the impact these changes may have on biodiversity. Madagascar is of particular interest as it harbours unique biodiversity. The lemurs on Madagascar represent a distinct radiation of primates and make up 21% of the species in this order. Yet, the processes that have led to current species distributions across Madagascar remain unresolved. Aye-ayes have the widest geographic distribution of all lemurs and are found across multiple forest types on the island. However, their cryptic nature makes them especially elusive and therefore relatively little is known about their evolutionary history. I make use of innovations in the field of molecular genomics to sample genomic regions of this species to elucidate historic gene flow among populations. I developed a novel method of sampling mitochondrial DNA from aye-ayes’ distinct feeding traces to sample from two sites in south-east and west of Madagascar towards the extents of the aye-aye’s geographic distribution. These data supplemented sampling by Madagascar Biodiversity Partnership to provide the most geographically extensive genomic sampling of this species to date. I obtained genomic DNA to investigate the role of biogeographic processes and sex-biased dispersal in aye-ayes’ population genomic structure. I used different genomic markers to assess diversity and to resolve mechanisms that have led to aye-aye population genomic structure. I revealed matrilineal structure on the maternally inherited markers, whereas male-specific Y-chromosome marker systems showed weak structure, indicating male-mediated gene flow. Analysis of diversity in a phylogeographic context indicated that geographic distance drives genomic structure, yet I show some support for two biogeographic hypotheses which suggest that changes to riparian vegetation during the Pleistocene may have impacted connectivity among aye-aye populations. I provide interesting avenues for future research to better understand lemur biogeography and social organization, and findings can be integrated into conservation planning, particularly initiatives with focus on protecting genomic diversity in this species.
Reduced mRNA expression of D4 Receptor in blood lymphocytes among mixed opioid and amphetamine-type stimulants-use disorder.
Creators: name: Khadijah, MUHAMAD JAMIL Nur
name: Asma, ABDULLAH Nurul
name: AHMAD Imran
name: Ruzilawati, ABU BAKAR
Publisher: name: Zenodo
Year: 2021
Subjects: mRNA expression
D4 Receptor
mixed opioid and amphetamine-type stimulants-use disorder
dopamine receptors
peripheral blood lymphocytes
addiction

description: Introduction:
 The rewarding effects of Opioid and amphetamine type stimulant (ATS) is exerted by stimulating the dopaminergic system in the mesolimbic area. Dopamine system in peripheral blood lymphocytes has been suggested to reflect the central dopamine system's activity and pathology, especially in addiction and other neuropsychiatric diseases. The present study assessed the effect of mixed opioid and ATS addiction tawards mRNA expression of dopamine receptors in peripheral blood lymphocytes (PBLs) among drug dependent subjects (n=36) undergoing methadone maintenance therapy in comparison to control subjects (n=36). Materials and methods:
 Ten mL blood were obtained from the subjects followed by lymphocyte isolation, RNA extraction and reverse transcription. DRD4 and DRD5 mRNA expression in peripheral lymphocytes was assessed using real-time PCR. Results:
 The DRD4 mRNA expression but not DRD5 was significantly reduced in the peripheral lymphocytes of subjects.Mean expression value for DRD4 was 14.0+0.24 among patients and 13.3+0.25 among control subjects. For DRD5 it was 12.87 + 0.75 among patients and 12.59 +1.24 among controls. Conclusion:
 Mixed opioid and ATS addiction was associated with persistent deficiency of DRD4 but not DRD5 in PBLs. Disclaimer: Abstract text might vary slightly from what is displayed in the e-poster.
description: This poster was submitted to the 14th National Conference for Clinical Research (NCCR) in August 18-20, 2021. https://nccrconference.com.my/
Timing characterization of 100 GHz passively mode-locked discrete mode laser diodes
Creators: name: Bitauld, David
name: Osborne, Simon
name: O'Brien, Stephen
Publisher: name: arXiv
Year: 2011
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We report on the characterization of the timing stability of passively mode-locked discrete mode diode laser sources. These are edge-emitting devices with a spatially varying refractive index profile for spectral filtering. Two devices with a mode-locking frequency of 100 GHz are characterized. The first device is designed to support a comb of six modes and generates near Fourier limited 1.9 ps pulses. The second supports four primary modes resulting in a sinusoidal modulation of the optical intensity. Using a cross-correlation technique, we measured a 20 fs pulse to pulse timing jitter for the first device, while, for the second device, a mode-beating (RF) linewidth of 1 MHz was measured using heterodyne mixing in a semiconductor optical amplifier. Comparison of these results with those obtained for an equivalent Fabry-Perot laser indicates that the spectral filtering mechanism employed does not adversely affect the timing properties of these passively mode-locked devices.
The Desert Fathers' Beasts: Crocodiles in Medieval German Monastic Literature
Creators: name: Traulsen, Johannes
Publisher: name: Interfaces: A Journal of Medieval European Literatures
Year: 2019
Subjects: Hagiography; Animal; Crocodile; Vitaspatrum; Ascetic Literature

description: This paper explores the literary representations of one of the most terrifying animals in the medieval imagination, the crocodile, in two monastic texts written in the German vernacular (Väterbuch, Alemannische Vitaspatrum). The literary figure of the crocodile in these religious texts combines ancient knowledge of crocodiles, biblical motifs, allegorical attributions and the lived experience of the Christian hermits, who encountered crocodiles as a part of their environment. Thus, crocodiles appear simultaneously as representations of divine power, as devilish beasts, as challenges to ascetic life in the desert, and as creatures miraculously tamed by the hermits' charisma. The ambiguous status of the desert as a space of temptation and redemption is thus reflected in literary representations of the crocodile, which in turn can be understood as a reflection on monastic life in general, intended for the medieval audience of the texts discussed.
description: Interfaces: A Journal of Medieval European Literatures, N. 5 (2018): Biblical Creatures: The Animal as an Object of Interpretation in Pre-Modern Christian and Jewish Hermeneutic Traditions
A Man Fighting a Lion: A Christian 'Theme' in Yiddish Epics
Creators: name: Roman, Oren
Publisher: name: Interfaces: A Journal of Medieval European Literatures
Year: 2019
Subjects: Typology; Jewish-Christian Relations; Epic poetry; Biblia pauperum; Yiddish

description: During the medieval and early modern periods, lions served as a common motif in Ashkenazic Jewish culture, bearing diverse symbolism. Also in literature written in Yiddish, the vernacular language of Ashkenazic Jews, lions were often mentioned. In this article, three songs about a man fighting a lion – Samson, David, and Benaiah – found within early modern Yiddish epics, are presented. An analysis of these songs' similar content and form suggests that they are short epic songs which have been initially orally transmitted, and later incorporated into the written long epics in Yiddish which have come down to us. In two of the songs the hero holds the lion's mouth with both hands, shortly before subduing him, an image common in Jewish art but lacking any basis in Jewish texts. This study identifies a Christian background to this image, namely that Samson's battle with the lion foreshadows the Harrowing of Hell and Jesus' releasing mankind’s souls from eternal damnation. The study points to the close cultural ties between Jews and Christians in the medieval and early modern eras, which were possible in the sphere of vernacular Yiddish literature. This closeness brought about influences which do not seem to exist in Hebrew literature.
description: Interfaces: A Journal of Medieval European Literatures, N. 5 (2018): Biblical Creatures: The Animal as an Object of Interpretation in Pre-Modern Christian and Jewish Hermeneutic Traditions
The Hyena's Cave: 'Jeremiah' 12.9 in Premodern Bestiaries
Creators: name: Kraß, Andreas
Publisher: name: Interfaces: A Journal of Medieval European Literatures
Year: 2019
Subjects: subject: Hyena; Jeremiah; Bestiary; Sexuality; Gender
subject: Language and Literature

description: The premodern bestiary tradition portrays the hyena as a creature that annually changes its sex. While the Greek Physiologus interprets it as an allegory of sexual aberration, the various versions of the Latin Physiologus read it as a symbol for religious duplicity. Since the late twelfth century, the bestiaries transform the hyena into a signifier of the abominable par excellence. Throughout the bestiary tradition, the interpretation of the hyena draws on a quotation from the Book of Jeremiah where God compares his land to a hyena's cave (Jer. 12.9).
description: Interfaces: A Journal of Medieval European Literatures, N. 5 (2018): Biblical Creatures: The Animal as an Object of Interpretation in Pre-Modern Christian and Jewish Hermeneutic Traditions
Thermal Shock Effects Modeling On A Globe Valve Body-Bonnet Bolted Flange Joint
Creators: name: Mathieu, Jean-Philippe
name: Rit, Jean-François
name: Ferrari, Jerome
name: Hersant, David
Publisher: name: arXiv
Year: 2012
Subjects: subject: Classical Physics (physics.class-ph)
subject: FOS: Physical sciences

description: This paper attends to show efforts made at EDF R&D to improve comprehension of valve parts loadings during operation. Thermal shock in a globe valve is represented and modeled using EDF R&D Finite Element Analysis code (Code_Aster). Choices of modeling are discussed and balanced on the basis of "what an engineer can obtain without becoming a researcher". First simulation results are presented. Attention is focused on the evolution of Body-Bonnet Bolted Flange Joint (BBBFJ) tightening forces which are simulated during the thermal shock. An experimental setup is also presented for the studied valve, which implies thermocouple implementation for comparison of the simulated thermal field and strain measurement on each threaded rod to validate the mechanical modeling.
Additional file 1 of Attention-deficit/hyperactivity disorder (ADHD) symptoms and their relation to diagnosed ADHD, sociodemographic characteristics, and substance use among patients receiving opioid agonist therapy: a Norwegian cohort study
Creators: name: Vold, Jørn Henrik
name: Halmøy, Anne
name: Chalabianloo, Fatemeh
name: Pierron, Marianne Cook
name: Løberg, Else-Marie
name: Johansson, Kjell Arne
name: Fadnes, Lars Thore
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
classificationCode: 111714
subject: Mental Health

description: Additional file 1. US-English and Norwegian versions of the Adult ADHD self-report scale version 1.1, part A, and part B, question 9. Legends: ADHD: Attention-deficit/hyperactivity disorder.
Naomh Breandáin Credit Union & Asset Based Community Development as a Strategy
Creators: name: Naomh Breandain Credit Union Limited
Publisher: name: Zenodo
Year: 2023

description: The following report considers whether asset-based community development may be a useful lens and strategic framework for NBCU  to serve their membership and communities. It will be used as the basis for discussion at a Board Meeting on 21st September 2023  . The report was commissioned in July 2023 by the board of Naomh Breandáin Credit Union and has been written by Cormac Russell, Founding Director of Nurture Development and faculty member of the ABCD Institute at DePaul University, Chicago. The inquiry question underpinning the report is: Can the Asset-Based Community Development (ABCD) Approach Serve Naomh Breandáin Credit Union (NBCU)  in Serving its Community?
Ontogeny of hepatic drug metabolizing enzymes in sheep
Creators: name: Pretheeban, Manoja
Publisher: name: University of British Columbia
Year: 2010

description: Administration of therapeutic, supplemental and social drugs to the mother during pregnancy exposes the fetus to these medicines and their metabolites, which can cause defects in nervous, renal, cardiac and metabolic functions. Hepatic metabolic enzymes such as cytochrome P450 (CYP) 2A6, 2C19, 2D6 and UDP glucuronosyltransferases (UGT) 1A6, 1A9, 2B7 are important for the metabolism of many drugs. In order to understand whether these drugs are safe enough during pregnancy and in postnatal period, knowledge of the expression levels of these enzymes in different developmental stages is important. Therefore we proposed to clone the CYP and UGT genes and quantify these enzymes at gene and protein levels at different developmental stages such as fetus, newborn and adults. This study was performed in sheep (adult n=4; newborn n=3; and fetus n=3) liver to compare the mRNA and protein expression levels of the above enzymes and a regulatory factor, Hepatic Nuclear Factor 4α (HNF4α). The effect of antenatal glucocorticoid on these enzymes was also studied by infusion of cortisol (0.45mg/h; 80h) to another group of fetuses (n=5). Sheep sequences were cloned and real time PCR was performed to analyze the relative mRNA expression levels in the above four groups. Microsomes were prepared and western blot analysis was performed using human or rat antibodies to measure the relative protein expression levels. In terms of mRNA and protein expression of the above mentioned enzymes, fetal and newborn levels were very low compared to the adult. Some CYP proteins (CYP2A, CYP2C) were absent in the fetus and even in newborns (CYP2A). Sheep UGT protein levels were not measured since the human UGT antibodies did not work. Glucocorticoid plays a role in up regulating both the mRNA and protein expression of CYP2D6. Moreover the correlation observed between the above enzymes and HNF4α indicates a possible regulatory role in sheep similar to that in humans. The findings of this study follow a similar pattern found in the human and indicate that fetal and newborn lambs have a reduced ability to metabolize drugs that are substrates of these CYP isoforms.