cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The quantum Levy walk
Creators: name: Cáceres, Manuel O.
name: Nizama, Marco
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We introduce the quantum Levy walk to study transport and decoherence in a quantum random model. We have derived from second order perturbation theory the quantum master equation for a \textit{Levy-like particle}that moves along a lattice through hopping scale-free while interacting with a thermal bath of oscillators. The general evolution of the quantum Levy particle has been solved for different preparations of the system. We examine the evolution of the quantum purity, the localized correlation, and the probability to be in a lattice site, all them leading to important conclusions concerning quantum irreversibility and decoherence features. We prove that the quantum thermal mean-square displacement is finite under a constraint that is different when compared to the classical Weierstrass random walk. We prove that when the mean-square displacement is infinite the density of state has a complex null-set inside the Brillouin zone. We show the existence of a critical behavior in the continuous eigenenergy which is related to its non-differentiability and self-affine characteristics. In general our approach allows to study analytically quantum fluctuations and decoherence in a long-range hopping model.
description: 26 pages, 6 figures
The Radiative Flavor Template at the LHC: Lepton non-universality and g-2
Creators: name: Cacciapaglia, Giacomo
name: Cagnotta, Antimo
name: Calabrese, Roberta
name: Carnevali, Francesco
name: De Iorio, Agostino
name: Iorio, Alberto Orso Maria
name: Morisi, Stefano
name: Sannino, Francesco
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The Standard Model of Particle Physics and its description of Nature have been recently challenged by a series of precision measurements performed via different accelerator machines. Statistically significant anomalies emerged in the heavy meson physics sector, when measuring the muon magnetic momentum, and very recently when deducing the mass of the W boson. Here we consider a radiative extension of the Standard Model devised to be sufficiently versatile to reconcile the various experimental results while further predicting the existence of new bosons and fermions with a mass spectrum in the TeV energy scale. The resulting spectrum is, therefore, within the energy reach of the proton-proton collisions at the LHC experiments at CERN. The model investigated here allows to interpolate between composite and elementary extensions of the Standard Model with emphasis on a new modified Yukawa sector that is needed to accommodate the anomalies. Focusing on the radiative regime of the model, we introduce interesting search channels of immediate impact for the ATLAS and CMS experimental programs such as the associate production of Standard Model particles with either invisible or long-lived particles. We further show how to adapt earlier SUSY-motivated searchers of new physics to constrain the spectrum and couplings of the new scalars and fermions. Overall, the new physics template simultaneously accounts for the bulk of the observed experimental anomalies while suggesting a wide spectrum of experimental signatures relevant for the current LHC experiments.
description: 38 pages, 60 figures, 4 tables
A Blichfeldt-type inequality for centrally symmetric convex bodies
Creators: name: Henze, Matthias
Publisher: name: arXiv
Year: 2012
Subjects: subject: Metric Geometry (math.MG)
subject: FOS: Mathematics
subject: 52C07, 52B20, 52A40, 11H06

description: In this note, we derive an asymptotically sharp upper bound on the number of lattice points in terms of the volume of centrally symmetric convex bodies. Our main tool is a generalization of a result of Davenport that bounds the number of lattice points in terms of volumes of suitable projections.
description: 9 pages
Platelets, thrombin generation and extracellular vesicles: the effects of prematurity and COVID-19 on neonatal coagulation
Creators: name: Murphy, Claire
Publisher: name: Royal College of Surgeons in Ireland
Year: 2023
Subjects: classificationCode: 321399
subject: Paediatrics not elsewhere classified
classificationCode: 320102
subject: Haematology
classificationCode: 321502
subject: Obstetrics and gynaecology

description: Premature infants are at increased risk of haemorrhage, have reduced levels of coagulation factors, and hyporeactive platelets in vitro. Despite prolonged standard clotting times, thrombin generation is similar or increased in preterm compared with term plasma. Extracellular vesicles (EVs) are tiny particles released from cells and evidence suggests they may have a role in haemostasis. COVID-19 can cause hypercoagulability and thrombosis. The effects of COVID-19 on pregnant women and the developing fetus are poorly understood. The EVENT Study, a prospective observational study, aimed to evaluate the impact of platelets on thrombin generation in preterm infants and the release of EVs during perinatal adaption. Umbilical cord blood and postnatal samples were collected from preterm infants (24-31 weeks) and healthy term controls. Coagulation was evaluated using Calibrated Automated Thrombography (CAT) in platelet rich plasma (PRP) and EVs were characterised by nanoparticle tracking analysis, flow cytometry and ELISA. Secondly, I aimed to evaluate the effects of COVID-19 infection during pregnancy. The neonatal clinical outcomes, of infants born to women with SARS-CoV-2 during pregnancy, were investigated in two retrospective studies, while a prospective case-control study evaluated the haematological impact, measured in cord blood. 101 preterm infants were recruited to the EVENT Study. Thrombin generation in PRP was hypercoagulable in preterm compared with term infants. There were changes in the concentration, size, cellular origin and procoagulant activity of EVs during perinatal adaption in both preterm and term infants. The clinical outcomes of infants born to women with SARS-CoV-2 were reassuring. There were no haematological abnormalities identified (n=15 cases) and thrombin generation was comparable between groups. This thesis supports the growing evidence that preterm infants are hypercoagulable, despite reported hyporeactive platelets. I describe changes in EVs during perinatal adaption. I present reassuring data on the neonatal clinical and haematological outcomes of a maternal COVID-19 infection during pregnancy.
Sequencing of Candidate Genes Selected by Beta Cell Experts in Monogenic Diabetes of Unknown Aetiology
Creators: name: Edghill, Emma L
name: Minton, Jayne A L
name: Groves, Christopher J
name: Flanagan, Sarah E
name: Patch, Ann-Marie
name: Rubio-Cabezas, Oscar
name: Shepherd, Maggie
name: Lenzen, Sigurd
name: McCarthy, Mark I
name: Ellard, Sian
name: Hattersley, Andrew T
Publisher: name: JOP. Journal of the Pancreas
Year: 2016
Subjects: Diabetes Mellitus, Type 2; Genetics, Insulin-Secreting Cells

description: Context Approximately 39% of cases with permanent neonatal diabetes (PNDM) and about 11% with maturity onset diabetes of the young (MODY) have an unknown genetic aetiology. Many of the known genes causing MODY and PNDM were identified as being critical for beta cell function before their identification as a cause of monogenic diabetes. Objective We used nominations from the EU beta cell consortium EURODIA project partners to guide gene candidacy. Subjects Seventeen cases with permanent neonatal diabetes and 8 cases with maturity onset diabetes of the young. Main outcome measures The beta cell experts within the EURODIA consortium were asked to nominate 3 "gold", 3 "silver" and 4 "bronze" genes based on biological or genetic grounds. We sequenced twelve candidate genes from the list based on evidence for candidacy. Results Sequencing ISL1, LMX1A, MAFA, NGN3, NKX2.2, NKX6.1, PAX4, PAX6, SOX2, SREBF1, SYT9 and UCP2 did not identify any pathogenic mutations. Conclusion Further work is needed to identify novel causes of permanent neonatal diabetes and maturity onset diabetes of the young utilising genetic approaches as well as further candidate genes.

Image: Peninsula Medical School logo. Exeter, United Kingdom.
description: JOP. Journal of the Pancreas, Vol 11, N° 1 (2010): January - P. 1-94
Pseudexechia trivittata
Creators: name: El Mouden, Mohamed Amin
name: Chandler, Peter J.
name: Saidoun, Imane
name: Driauach, Ouafaa
name: Belqat, Boutaïna
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Mycetophilidae
Pseudexechia
Pseudexechia trivittata

description: Pseudexechia trivittata (Stæger, 1840)
Material examined.
Morocco – Middle Atlas Region • 3 ♂♂; Gouffre Izora; 19/V/2022; K. Aattouch, M. El Ouahabi and M. A. El Mouden leg; UAE-FST MA 22/24118 • 2 ♂♂; Grotte Bouslama; 19/V/2022; K. Aattouch, M. El Ouahabi and M. A. El Mouden leg; UAE-FST MA 22/24119.
North African distribution.
New to Morocco and North Africa.
description: Published as part of El Mouden, Mohamed Amin, Chandler, Peter J., Saidoun, Imane, Driauach, Ouafaa & Belqat, Boutaïna, 2025, A new species of Docosia Winnertz, 1864 and new records of fungus gnats (Diptera, Bolitophilidae, Keroplatidae and Mycetophilidae) from North Africa, pp. 349-379 in ZooKeys 1233 on pages 349-379, DOI: 10.3897/zookeys.1233.130502
Anomalous Pancreaticobiliary Ductal Union in Tropical Calcific Pancreatitis
Creators: name: Khuroo, Naira Sultan
name: Khuroo, Mohammad Sultan
name: Khuroo, Mehnaaz Sultan
Publisher: name: JOP. Journal of the Pancreas
Year: 2016
Subjects: Bile Ducts; Calculi; Cholangiopancreatography, Endoscopic Retrograde; Pancreatitis; Pancreatitis, Chronic

description: Context Tropical calcific pancreatitis is unique to developing countries with of unknown origin. Objective We evaluated the pattern of pancreaticobiliary ductal union in patients with tropical calcific pancreatitis. Patients Twenty-one patients with tropical calcific pancreatitis were compared to 174 control subjects with no pancreaticobiliary disease and 35 patients with alcohol-induced chronic pancreatitis. Main outcome measure Two experienced people, blinded to the results, evaluated the pattern of pancreaticobiliary ductal union. Pancreaticobiliary ductal unions were classified as: separate ducts (no union), a short common-channel (length less than 6 mm), a long common-channel (length ranging 6-15 mm) and anomalous pancreaticobiliary ductal union (length greater than 15 mm). Anomalous union was defined as P-B type when the pancreatic duct appeared to join the bile duct and B-P type when the bile duct appeared to join the pancreatic duct. Any disparities between the two investigators were sorted out by mutual discussion. Results Pancreaticobiliary ductal union in tropical calcific pancreatitis patients as compared to those in the control group was as follows: separate ducts, 23.8% vs. 49.4% (P=0.036); a short common-channel, 4.8% vs. 28.7% (P=0.017); a long common channel, 33.3% vs. 18.4% (P=0.144) and anomalous pancreaticobiliary ductal union, 38.1% vs. 3.4% (P<0.001). The B-P pattern of anomalous pancreaticobiliary ductal union was more frequent in tropical calcific pancreatitis than in the control group but there was no statistical significance (P=0.103). The angle of the pancreaticobiliary ductal union in the tropical calcific pancreatitis group was 88.1±36.2° as compared to 20.0±11.5° in control group (P<0.001). Alcohol-induced chronic pancreatitis (No. 35) predominantly had either separate ducts (65.7%) or a short common channel (25.7%). Conclusion We concluded that patients with tropical calcific pancreatitis in Kashmir had anomalous pancreaticobiliary ductal union, predominantly of B-P type with a wide angle of ductal union more frequently. This may be related to the etiology of tropical calcific pancreatitis in such regions.

Image: Large hepatic cystic lesions communicating with the bile ducts.
description: JOP. Journal of the Pancreas, Vol 11, N° 1 (2010): January - P. 1-94
Biased Random Walk on Spanning Trees of the Ladder Graph
Creators: name: Gantert, Nina
name: Klenke, Achim
Publisher: name: arXiv
Year: 2022
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60K37 60G50 60F05

description: We consider a specific random graph which serves as a disordered medium for a particle performing biased random walk. Take a two-sided infinite horizontal ladder and pick a random spanning tree with a certain edge weight $c$ for the (vertical) rungs. Now take a random walk on that spanning tree with a bias $β>1$ to the right. In contrast to other random graphs considered in the literature (random percolation clusters, Galton-Watson trees) this one allows for an explicit analysis based on a decomposition of the graph into independent pieces. We give an explicit formula for the speed of the biased random walk as a function of both the bias $β$ and the edge weight $c$. We conclude that the speed is a continuous, unimodal function of $β$ that is positive if and only if $β< β_c^{(1)}$ for an explicit critical value $β_c^{(1)}$ depending on $c$. In particular, the phase transition at $β_c^{(1)}$ is of second order. We show that another second order phase transition takes place at another critical value $β_c^{(2)}<β_c^{(1)}$ that is also explicitly known: For $β<β_c^{(2)}$ the times the walker spends in traps have second moments and (after subtracting the linear speed) the position fulfills a central limit theorem. We see that $β_c^{(2)}$ is smaller than the value of $β$ which achieves the maximal value of the speed. Finally, concerning linear response, we confirm the Einstein relation for the unbiased model ($β=1$) by proving a central limit theorem and computing the variance.
description: 29 pages, 9 figures
Incidence and Management of Arterial Anomalies in Patients Undergoing Pancreaticoduodenectomy
Creators: name: Perwaiz, Azhar
name: Singh, Amanjeet
name: Singh, Tanveer
name: Chaudhary, Adarsh
Publisher: name: JOP. Journal of the Pancreas
Year: 2016
Subjects: Pancreaticoduodenectomy; Vascular Malformations

description: Context Pancreaticoduodenectomy entails ligation of vascular arcades arising from the celiac and superior mesenteric arteries. These are known to have anatomical variations. Objective This study was aimed at analyzing the spectrum of arterial anomalies and their clinical impact on the procedure itself. Patients The study includes 200 consecutive patients who underwent a pancreaticoduodenectomy between September 2003 and May 2009 after excluding those having distant metastases or local unresectability. Main outcome measures The records of the patients were studied to assess the incidence of arterial anomalies and the operative complexities involved in a pancreaticoduodenectomy. Results Fifty-three patients (26.5%) had arterial anomalies. The complexity of the surgery was determined by the course of these arteries. The mean duration of surgery was 420±32.0 minutes in patients with arterial anomalies versus 370±38.5 minutes in those with a normal arterial anatomy (P= 0.005). Fifty-one out of 53 (96.2%) patients underwent pancreaticoduodenectomy with negative resection margins. The pancreaticoduodenectomy was abandoned in two cases due to patient- and tumor-related factors. Conclusion During pancreaticoduodenectomy, arterial anomalies can increase operative complexity but do not usually compromise the safety of the procedure or its oncological outcome.

Image: Celiac artery stenosis with tortuous pancreaticoduodenal arcade.
description: JOP. Journal of the Pancreas, Vol 11, N° 1 (2010): January - P. 1-94
A smooth transition towards a Tracy-Widom distribution for the largest eigenvalue of interacting $k$-body fermionic Embedded Gaussian Ensembles
Creators: name: Carro, Ernesto
name: Benet, Luis
name: Castillo, Isaac Pérez
Publisher: name: arXiv
Year: 2022
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: In spite of its simplicity, the central limit theorem captures one of the most outstanding phenomena in mathematical physics, that of universality. While this classical result is well understood it is still not very clear what happens to this universal behaviour when the random variables become correlated. A fruitful mathematically laboratory to investigate the rising of new universal properties is offered by the set of eigenvalues of random matrices. In this regard a lot of work has been done using the standard random matrix ensembles and focusing on the distribution of extreme eigenvalues. In this case, the distribution of the largest -- or smallest -- eigenvalue departs from the Fisher-Tippett-Gnedenko theorem yielding the celebrated Tracy-Widom distribution. One may wonder, yet again, how robust is this new universal behaviour captured by the Tracy-Widom distribution when the correlation among eigenvalues changes. Few answers have been provided to this poignant question and our intention in the present work is to contribute to this interesting unexplored territory. Thus, we study numerically the probability distribution for the normalized largest eigenvalue of the interacting $k$-body fermionic orthogonal and unitary Embedded Gaussian Ensembles in the diluted limit. We find a smooth transition from a slightly asymmetric Gaussian-like distribution, for small $k/m$, to the Tracy-Widom distribution as $k/m\to 1$, where $k$ is the rank of the interaction and $m$ is the number of fermions. Correlations at the edge of the spectrum are stronger for small values of $k/m$, and are independent of the number of particles considered. Our results indicate that subtle correlations towards the edge of the spectrum distinguish the statistical properties of the spectrum of interacting many-body systems in the dilute limit, from those expected for the standard random matrix ensembles.
description: 10 pages, 4 figures
Quantum coherence and its dephasing in the giant spin Hall effect and nonlocal voltage generated by magnetotransport through multiterminal graphene bars
Creators: name: Chen, Chien-Liang
name: Chang, Ching-Ray
name: Nikolic, Branislav K.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Motivated by the recent experimental observation [D. A. Abanin et al., Science 323, 328 (2011)] of nonlocality in magnetotransport near the Dirac point in six-terminal graphene Hall bars, for a wide range of temperatures and magnetic fields, we develop a nonequilibrium Green function (NEGF) theory of this phenomenon. In the phase-coherent regime and strong magnetic field, we find large spin Hall (SH) conductance in four-terminal bridges, where the SH current is pure only at the Dirac point (DP), as well as the nonlocal voltage at a remote location in six-terminal bars where the direct and inverse SH effect operate at the same time. The "momentum-relaxing" dephasing reduces their values at the DP by two orders of magnitude while concurrently washing out any features away from the DP. Our theory is based on the Meir-Wingreen formula with dephasing introduced via phenomenological many-body self-energies, which is then linearized for multiterminal geometries to extract currents and voltages.
description: 5 pages, 4 figures, PDFLaTeX
Shear-free perfect fluids with a solenoidal electric curvature
Creators: name: Bergh, Norbert Van den
name: Carminati, John
name: Karimian, Hamid Reza
name: Huf, Peter
Publisher: name: arXiv
Year: 2012
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We prove that the vorticity or the expansion vanishes for any shear-free perfect fluid solution of the Einstein field equations where the pressure satisfies a barotropic equation of state and the spatial divergence of the electric part of the Weyl tensor is zero.
description: 9 pages
War- and famine-related excess mortality among civilians in the Netherlands, 1944–1945
Creators: name: Ekamper, Peter
name: Bijwaard, Govert E.
name: Poppel, Frans W.A. Van
name: L.H. Lumey
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: National estimates exist for war- and famine-related deaths in the Netherlands during the last stages of World War II, but no such estimates are available at the local level. To fill this information gap, this article aims at mapping and visualizing the timing of war- and famine-related excess mortality by municipality among the civilian population within the Netherlands. We use mortality statistics at the level of municipalities because these are the smallest administrative units for which this information is available. We use a seasonally adjusted mortality model combined with a difference-in-difference approach to estimate the number of excess deaths in the period between January 1944 and July 1945 separately for each Dutch municipality.
High-precision measurement of the complex magneto-optical Kerr effect using weak measurement
Creators: name: Li, Tong
name: Wang, Yunhan
name: Jiang, Yinghang
name: Zhang, Sijie
name: Luo, Lan
name: Zhang, Zhiyou
Publisher: name: arXiv
Year: 2023
Subjects: subject: Optics (physics.optics)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: The present paper introduces a quantum weak measurement (WM) scheme for the measurement of the complex magneto-optical Kerr effect (MOKE). We achieve the simultaneous measurement of the Kerr rotation angle and the ellipticity in a single WM process by utilizing two auxiliary pointers derived from the same meter state. The experimental measurement precision for both the Kerr rotation angle and the ellipticity is capable of reaching $10^{-4}$ deg. This technique is also employed for the determination of the complex magneto-optical constant $Q$. The proposed method overcomes the limitation of acquiring the complex magneto-optical Kerr parameters through a multi-step measurement process, which was previously encountered. This breakthrough holds immense significance for efficiently measuring and applying the complex MOKE with high precision and cost-effectiveness.
Strand-based musculotendon simulation of the hand
Creators: name: Sueda, Shinjiro
Publisher: name: University of British Columbia
Year: 2011

description: This dissertation develops a framework for modelling biomechanical systems, with special focus on the muscles, tendons, and bones of the human hand. Two complementary approaches for understanding the functions of the hand are developed: the strand simulator for computer modelling, and an imaging apparatus for acquiring a rich data set from cadaver hands. Previous biomechanical simulation approaches, based on either lines-of-force or solid mechanics models, are not well-suited for the hand, where multiple contact constraints make it difficult to route muscles and tendons effectively. In lines-of-force models, wrapping surfaces are used to approximate the curved paths of tendons and muscles near joints. These surfaces affect only the kinematics, and not the dynamics, of musculotendons. In solid mechanics models, the 3D deformation of muscles can be fully accounted for, but these models are difficult to create and expensive to simulate; moreover, the fibre-like properties of muscles are not directly represented and must be added on as auxiliary functions. Neither of these approaches properly handles both the dynamics of the musculotendons and the complex routing constraints. We present a new, strand-based approach, capable of handling the coupled dynamics of muscles, tendons, and bones through various types of routing constraints. The functions of the hand can also be studied from the analysis of data obtained from a cadaver hand. We present a hardware and software setup for scanning a cadaver hand that is capable of simultaneously obtaining the skeletal trajectory, tendon tension and excursion, and tendon marker motion. We finish with a preliminary qualitative comparison of a simulation model of the index finger with real world data acquired from ex vivo specimen, using the strands framework.
Cytokines and Exocrine Pancreatic Cancer: Is There a Link?
Creators: name: Basso, Daniela
name: Plebani, Mario
Publisher: name: JOP. Journal of the Pancreas
Year: 2016
Subjects: Cytokines; Pancreatic Neoplasms

description: No abstract available.

Image: Schematic representation of TGFbeta1 signal transduction pathway via Smad proteins.
description: JOP. Journal of the Pancreas, Vol 1, N° 2 (2000): July - p. 19-45
A Keck/LRIS Spatially-Resolved Spectroscopic Study of a LINER Galaxy SDSS J091628.05+420818.7
Creators: name: Bae, Hyun-Jin
name: Woo, Jong-Hak
name: Yagi, Masafumi
name: Yoon, Suk-Jin
name: Yoshida, Michitoshi
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Using spatially-resolved spectra obtained with the Low Resolution Imaging Spectrometer at the Keck I telescope, we investigate the nature of ionizing sources and kinematic properties of emission-line gas in a LINER galaxy SDSS J091628.05+420818.7, which is a nearby (z = 0.0241) and bright (M_r = -20.2) early-type galaxy. After subtracting stellar absorption features using a combination of simple stellar population models, we measure the flux, line-of-sight velocity, and velocity dispersion of four emission lines, i.e., Hα, Hβ, [O III] λ5007, and [N II] λ6584, to study radial change of emission-line fluxes and velocities. Compared to the point-spread-function of the observation, the emission-line region is slightly extended but comparable to the seeing size. The central concentration of emission-line gas suggests that ionization is triggered by a nuclear source, excluding old stellar population as ionizing sources. We find that emission-line gas is counter-rotating with respect to stellar component and that the [O III] λ5007 line is blueshifted compared to other emission lines, possibly due to an outflow.
description: 10 pages, 8 figures; Accepted for publication in ApJ
Accounting for Mobility in Alternatives AssessmentsInsights from the ZeroPM Project
Creators: name: Arp, Hans Peter H.
name: Cousins, Ian
name: Figuière, Romain
name: Peters, Greag
Publisher: name: Zenodo
Year: 2023
Subjects: Alternatives Assessment
MCDA
PFAS
PMT

description: Chemicals that pose the greatest threat to aquatic environments and drinking water sources are those that are persistent, mobile and toxic (PMT) and very persistent very mobile (vPvM) substances. The ZeroPM project – Zero Pollution of Persistent, Mobile (PM) substances – is a multi-year research effort funded through the European Commission’s Horizon 2020 research and innovation program. The project aims to guide policy, technological and market incentives to minimize use, emissions and pollution of entire groups of PM substances. In this A4 webinar, we will hear from the ZeroPM project and its work to advance the accounting of substance mobility attributes in alternatives assessment processes. Presenters will provide an overview of the ZeroPM project; the persistent, mobile and toxic (PMT) and very persistent, very mobile (vPvM) hazard criteria that have been recently adopted by the European Commission as part of the revision to the Classification Labeling and Packaging (CLP) regulation; the utility of essential use and substance grouping concepts as it relates to PM substances and considerations for alternatives assessments, using chemicals used as flame retardants and cosmetics as a case study; and looking forward the use of “big data” approaches to identify functional alternatives for prioritized PM substances.
On Optimal Subarchitectures for Quantum Circuit Mapping
Creators: name: Peham, Tom
name: Burgholzer, Lukas
name: Wille, Robert
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: Discrete Mathematics (cs.DM)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Compiling a high-level quantum circuit down to a low-level description that can be executed on state-of-the-art quantum computers is a crucial part of the software stack for quantum computing. One step in compiling a quantum circuit to some device is quantum circuit mapping, where the circuit is transformed such that it complies with the architecture's limited qubit connectivity. Because the search space in quantum circuit mapping grows exponentially in the number of qubits, it is desirable to consider as few of the device's physical qubits as possible in the process. Previous work conjectured that it suffices to consider only subarchitectures of a quantum computer composed of as many qubits as used in the circuit. In this work, we refute this conjecture and establish criteria for judging whether considering larger parts of the architecture might yield better solutions to the mapping problem. We show that determining subarchitectures that are of minimal size, i.e., of which no physical qubit can be removed without losing the optimal mapping solution for some quantum circuit, is a very hard problem. Based on a relaxation of the criteria for optimality, we introduce a relaxed consideration that still maintains optimality for practically relevant quantum circuits. Eventually, this results in two methods for computing near-optimal sets of subarchitectures$\unicode{x2014}$providing the basis for efficient quantum circuit mapping solutions. We demonstrate the benefits of this novel method for state-of-the-art quantum computers by IBM, Google and Rigetti.
description: 19 pages, 9 figures, 3 tables
title: MAPT genotype-dependent mitochondrial aberration and ROS production trigger dysfunction and death in cortical neurons of patients with hereditary FTLD
Creators: name: Korn, Lisanne
name: Speicher, Anna M.
name: Schroeter, Christina Barbara
name: Gola, Lukas
name: Kaehne, Thilo
name: Engler, Alexander
name: Disse, Paul
name: Fernandez-Orth, Juncal
name: Csatári, Júlia
name: Naumann, Michael
name: Seebohm, Guiscard Friedrich Aldous
name: Meuth, Sven
name: Schöler, Hans Robert
name: Wiendl, Heinz
name: Kovać, Stjepana
name: Pawlowski, Matthias
Publisher: name: University of Muenster, Institutional Repository MIAMI
Year: 2023
Subjects: subject: 610 Medicine and health

description: Tauopathies are a major type of proteinopathies underlying neurodegenerative diseases. Mutations in the tau-encoding 'MAPT-gene' lead to hereditary cases of frontotemporal lobar degeneration (FTLD)-tau, which span a wide phenotypic and pathological spectrum. Some of these mutations, such as the N279K mutation, result in a shift of the physiological 3R/4R ratio towards the more aggregation prone 4R isoform. Other mutations such as V337M cause a decrease in the in vitro affinity of tau to microtubules and a reduced ability to promote microtubule assembly. Whether both mutations address similar downstream signalling cascades remains unclear but is important for potential rescue strategies. Here, we developed a novel and optimised forward programming protocol for the rapid and highly efficient production of pure cultures of glutamatergic cortical neurons from hiPSCs. We apply this protocol to delineate mechanisms of neurodegeneration in an FTLD-tau hiPSC-model consisting of 'MAPTN279K- or MAPTV337M-mutants' and wild-type or isogenic controls. The resulting cortical neurons express MAPT-genotype-dependent dominant proteome clusters regulating apoptosis, ROS homeostasis and mitochondrial function. Related pathways are significantly upregulated in 'MAPTN279K' neurons but not in 'MAPTV337M' neurons or controls. Live cell imaging demonstrates that both MAPT mutations affect excitability of membranes as reflected in spontaneous and stimulus evoked calcium signals when compared to controls, albeit more pronounced in 'MAPTN279K' neurons. These spontaneous calcium oscillations in 'MAPTN279K' neurons triggered mitochondrial hyperpolarisation and fission leading to mitochondrial ROS production, but also ROS production through NOX2 acting together to induce cell death. Importantly, we found that these mechanisms are 'MAPT' mutation-specific and were observed in 'MAPTN279K' neurons, but not in 'MAPTV337M' neurons, supporting a pathological role of the 4R tau isoform in redox disbalance and highlighting 'MAPT-mutation' specific clinicopathological-genetic correlations, which may inform rescue strategies in different 'MAPT' mutations.
description: Finanziert durch den Open-Access-Publikationsfonds der Universität Münster.
Cytokine Gene Polymorphisms in Acute Pancreatitis
Creators: name: Sargen, Kevin
name: Demaine, Andrew G
name: Kingsnorth, Andrew N
Publisher: name: JOP. Journal of the Pancreas
Year: 2016
Subjects: Inflammatory Response; Interleukin-10; Tumour Necrosis Factor

description: Context Pro-inflammatory and regulatory cytokines play a key role in the pathogenesis of acute pancreatitis. Genetic loci encoding cytokines have been shown to be polymorphic, in some cases influencing protein expression. Objective To investigate if TNF and IL-10 gene loci are associated with the occurrence or severity of acute pancreatitis. Setting Acute surgical unit within large district hospital serving a population of 500,000. Methods Three TNF microsatellite loci (TNFa, TNFb, TNFc), the TNF-308 polymorphism, the IL-10.G microsatellite locus, and 3 bi-allelic polymorphisms in the IL-10 5’ region were typed using PCR in 135 acute pancreatitis patients and ethnically matched normal controls (n=107). Aetiology of disease was determined and patients grouped according to disease severity by assigning an organ failure score or classification according to the Atlanta system. Main outcome measures Allelic frequency of polymorphic loci in patients with different aetiology and disease course in acute pancreatitis. Results No difference was noted in allelic frequency of any of the cytokine gene loci between groups stratified according to disease severity. When aetiology was studied again there was no significant difference in allelic frequency. Conclusions The cytokine gene polymorphisms studied play no part in determination of disease severity or susceptibility to acute pancreatitis.

Image: Structural formula of Tumor necrosis factor-alpha (TNF-alpha) (Author: Doxepine; Wikimedia Commons)
description: JOP. Journal of the Pancreas, Vol 1, N° 2 (2000): July - p. 19-45
MPEC 2025-F191 : 2025 FQ11
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2025
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2025 FQ11

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
BPS surface operators and calibrations
Creators: name: Drukker, Nadav
name: Trépanier, Maxime
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We present here a careful study of the holographic duals of BPS surface operators in the 6d ${\cal N}=(2,0)$ theory. Several different classes of surface operators have been recently identified and each class has a specific calibration form - a 3-form in $AdS_7\times S^4$ whose pullback to the M2-brane world-volume is equal to the volume form. In all but one class, the appropriate forms are closed, so the action of the M2-brane is easily expressed in terms of boundary data, which is the geometry of the surface. Specifically, for surfaces of vanishing anomaly, it is proportional to the integral of the square of the extrinsic curvature. This can be extended to the case of surfaces with anomalies, by taking the ratio of two surfaces with the same anomaly. This gives a slew of new expectation values at large $N$ in this theory. For one specific class of surface operators, which are Lagrangian submanifolds of ${\mathbb R}^4\subset {\mathbb R}^6$, the structure is far richer and we find that the M2-branes are special Lagrangian submanifold of an appropriate six-dimensional almost Calabi-Yau submanifold of $AdS_7\times S^4$. This allows for an elegant treatment of many such examples.
description: 15 pages
Topographic and thematic (in)visibility of Small Island Developing States in a world map
Creators: name: Gosling-Goldsmith, Jessica
name: Ricker, Britta
name: Kraak, Menno Jan
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Many world maps visualize global data to represent the statistical and spatial relationships among countries. These maps are typically printed in reports or displayed online at a small scale. At such scale, small nations are difficult to perceive or even disappear, as is often the case for Small Island Developing States (SIDS), a group of more than fifty island states designated by the United Nations for their social, economic and environmental vulnerabilities. While the United Nations aims to address the social, economic and environmental challenges world-wide through the Sustainable Development Goals (SDGs), SIDS can be missing from maps presenting SDG indicator data. This constitutes five percent of the world population missing from maps. We propose maps and visual representations to address the perceptibility of SIDS and the availability of their indicator data to offer a more complete visualization of the status towards achieving the SDGs.
Early Prediction in Acute Pancreatitis: the Contribution of Amylase and Lipase Levels in Peritoneal Fluid
Creators: name: Frossard, Jean Louis
name: Robert, John
name: Soravia, Claudio
name: Mensi, Noury
name: Magnin, Anne
name: Hadengue, Antoine
name: Rohner, Adrien
name: Morel, Philippe
Publisher: name: JOP. Journal of the Pancreas
Year: 2016
Subjects: Casuality; Peritoneal Lavage

description: Context Predicting the severity of acute pancreatitis early in the course of the disease is still difficult. Objective The value of amylase and lipase levels in serum and peritoneal fluid might be of value in predicting the course of acute pancreatitis. Design Prospective study. Patients One-hundred and sixty-seven patients with acute pancreatitis as confirmed by computed tomography scan within 24 hours of admission were studied. Main outcome measures Each patient was given an enzymatic score which reflected the predominance of serum or peritoneal levels of amylase and/or lipase. Enzymatic score was 0 if neither enzyme was predominant in the peritoneal fluid, 1 if amylase or lipase alone were predominant and 2 if both enzymes were predominant. The predictive value of the enzymatic score or computed tomography scan for a severe attack was determined. Results One-hundred and thirty-three attacks were graded as mild (79.6%) and 34 were considered as severe (20.4%). The frequency of severe acute pancreatitis significantly increased as the enzymatic score increased (5.4%, 12.5%, and 31.7% in 0, 1, and 2 enzymatic score patients, respectively; P<0.001). An enzymatic score greater than 0 predicted a severe outcome in 32 of 34 patients (sensitivity 94.1%, specificity 26.3%), whereas an enzymatic score of 2 predicted a severe attack in 26 of 34 patients (sensitivity 76.5%, specificity 57.9%). Edema on computed tomography scan was found in 97 of 129 mild attacks (specificity 75.2%) and necrosis in 25 of 33 severe attacks (sensitivity 75.8%), whereas all patients with severe attacks exhibited extrapancreatic acute fluid collection (sensitivity 100%, specificity 34.9%). Conclusions Peritoneal dialysis is less predictive and more cumbersome than a computed tomography scan in the early prediction of acute pancreatitis.

Image: Ribbon diagram of human salivary alpha-amylase. (Wikimedia Commons)
description: JOP. Journal of the Pancreas, Vol 1, N° 2 (2000): July - p. 19-45
Effective Field Theory: A Modern Approach to Anomalous Couplings
Creators: name: Degrande, Celine
name: Greiner, Nicolas
name: Kilian, Wolfgang
name: Mattelaer, Olivier
name: Mebane, Harrison
name: Stelzer, Tim
name: Willenbrock, Scott
name: Zhang, Cen
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We advocate an effective field theory approach to anomalous couplings. The effective field theory approach is the natural way to extend the standard model such that the gauge symmetries are respected. It is general enough to capture any physics beyond the standard model, yet also provides guidance as to the most likely place to see the effects of new physics. The effective field theory approach also clarifies that one need not be concerned with the violation of unitarity in scattering processes at high energy. We apply these ideas to pair production of electroweak vector bosons.
description: 16 pages, 1 figure
Spatial visualization of quantitative landscape changes in an industrial region between 1827 and 1883. Case study Katowice, southern Poland
Creators: name: Paweł Cybulski
name: Łukasz Wielebski
name: Medyńska-Gulij, Beata
name: Lorek, Dariusz
name: Horbiński, Tymoteusz
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Space Science
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified

description: The aim of the study is to present landscape changes in the nineteenth century in the central part of the Upper Silesian Industrial District, which is the municipality of Katowice (southern Poland). The comparison of changes, particularly components of the geographical environment, is based on two time periods – the year 1827 and 1883. Nineteenth-century maps were georeferenced, digitized and a series of thematic spatial visualizations presenting quantitative changes were generated by means of the Geographic Information System (GIS). The scale of the visualization created is 1:100,000 and the area is 16,400 ha. The spatial visualization of quantitative landscape change shows the development of the anthropogenic pressure in the form of settlement areas, raw materials extraction places, roads, and the decrease of natural environments, such as forests, rivers, and water bodies. These changes were caused mainly by the exploration of underground deposits and the rapidly growing population of Upper Silesia.
Lines analysis in the Ophiuchus molecular cloud:  Gas in the ODISEA survey.
Creators: name: Gonzalez Ruilova, Camilo
Publisher: name: Zenodo
Year: 2023

description: The characterization of the molecular gas, around young stellar objects (YSOs) and protoplanetary disks, it is very important for the understanding in the stars evolution and planetary formation at early stages. The ODISEA survey corresponds to the largest sample of low YSOs in the Ophiuchus molecular cloud, with ∼300 targets from class I to III. Here we present the line analysis at 150 au angular resolution for all the mentioned objects, including extended emission, and rotating gaseous disks. Showing the morphology, the mass and size estimation, and correlation for the gas related to the central source. This research represents one of the largest samples, for the demographic statistics of gas, associated with YSOs in the same molecular cloud.
Pancreatic Schwannoma: A Case Report and Literature Review with Special Reference to Imaging Features
Creators: name: Suzuki, Shiji
name: Kaji, Satoshi
name: Koike, Nobusada
name: Harada, Nobuhiko
name: Hayashi, Tsuneo
name: Suzuki, Mamoru
name: Hanyu, Fujio
name: Ban, Shinichi
Publisher: name: JOP. Journal of the Pancreas
Year: 2016
Subjects: Diagnostic Imaging; Neurilemmoma; Pancreas

description: Context We report the imaging features of pancreatic schwannomas, a rare benign type of pancreatic tumor. Case report A 66-year-old woman was admitted to our hospital with a pancreatic tumor indicated in medical examinations. Computed tomography (CT), magnetic resonance imaging (MRI) and endoscopic ultrasonography (EUS) revealed a solid and cystic tumor, 3 cm in diameter, within the body of the pancreas. Contrast-enhanced CT, MRI and ultrasonography showed partial enhancement in the solid component. Endoscopic retrograde cholangiopancreatography (ERCP) and angiography showed no abnormal findings. A distal pancreatectomy together with a splenectomy and lymph node dissection were performed with a tentative diagnosis of mucinous cystic neoplasm of the pancreas. The cut surface of the resected pancreas showed a well-demarcated, pale yellow, solid tumor within the pancreas parenchyma. Histopathological examination of the tumor revealed proliferation of the spindle cells showing interlacing and palisading patterns. Immunohistochemically, these spindle cells were positive for S-100 protein and vimentin, and negative for alpha-smooth muscle actin, CD34, and cytokeratin. Thus the tumor was diagnosed as a pancreatic schwannoma. Conclusion CT and US can detect pancreatic schwannomas as solid and cystic masses, and MRI shows a relatively characteristic feature. Imaging procedures such as CT, MRI and US are able to differentiate a pancreatic tumor, such as a pancreatic schwannoma.

Image: Contrast-enhanced US shows partial enhancement at the solid component.
description: JOP. Journal of the Pancreas, Vol 11, N° 1 (2010): January - P. 1-94
Remnant Pancreatectomy for Recurrent or Metachronous Pancreatic Carcinoma Detected by FDG-PET: Two Case Reports
Creators: name: Koizumi, Masaru
name: Sata, Naohiro
name: Kasahara, Naoya
name: Morishima, Kazue
name: Sasanuma, Hideki
name: Sakuma, Yasunaru
name: Shimizu, Atsushi
name: Hyodo, Masanobu
name: Yasuda, Yoshikazu
Publisher: name: JOP. Journal of the Pancreas
Year: 2016
Subjects: Carcinoma; Neoplasms, Second Primary; Pancreas; Pancreatectomy; Recurrence

description: Context Although surgical resection is the only curative therapeutic option for recurrent or metachronous pancreatic carcinomas, most such cancers are beyond surgical curability. We herein report on two rare cases of remnant pancreatectomy used to treat recurrent or metachronous pancreatic carcinomas. Case reports Case#1 A 65-year-old male developed weight loss and diabetes mellitus 83 months after a pylorus-preserving pancreaticoduodenectomy followed by two years of adjuvant chemotherapy (5-fluorouracil plus leucovorin plus mitomycin C) for a pancreatic carcinoma in the head of the pancreas (stage IA). An abdominal CT scan revealed a 3 cm tumor in the remnant pancreas which appeared as a ‘hot’ nodule on FDG-PET. A remnant distal pancreatectomy was performed and a pancreatic carcinoma similar in profile to the primary lesion (stage IIB) was confirmed pathologically. Case#2 A 67-year-old male showed increased CA 19-9 levels 25 months after a distal pancreatectomy for a pancreatic carcinoma in the body of the pancreas (stage IA). An abdominal CT scan revealed a cystic lesion in the cut end of the pancreas which appeared as a ‘hot’ nodule on FDG-PET. A remnant proximal pancreatectomy with duodenectomy was performed and a metachronous pancreatic carcinoma (stage III) was confirmed pathologically. Conclusion Remnant pancreatectomy can be considered a treatment option for recurrent or metachronous pancreatic carcinomas. FDG-PET can play a key role in detecting remnant pancreatic carcinomas.

Image: FDG-PET showing a hot spot at the cut end of the pancreatic head.
description: JOP. Journal of the Pancreas, Vol 11, N° 1 (2010): January - P. 1-94