cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Regulation of Jak1 and Jak2 Synthesis through Non-Classical Progestin Receptors
Creators: name: Adams, Hillary
Publisher: name: University of Massachusetts Amherst
Year: 2015

description: The anteroventral periventricular (AVPV) nucleus of the hypothalamus integrates estradiol (E2) and progesterone (P4) feedback signals from the ovaries to stimulate gonadotropin releasing hormone (GnRH) neurons and trigger an ovulatory surge in luteinizing hormone (LH). E2 maintains the daily cyclic LH surge and P4 quickly amplifies the surge and limits it to one day. P4 amplification of the surge and rapid signaling in the AVPV may occur through its non-classical progestin receptors. Previous in vitro studies using a microarray analysis with N42 mouse embryonic hypothalamic neurons suggest that progesterone membrane component 1 (Pgrmc1) regulates genes linked to the janus kinase (Jak)/signal transducer and activator of transcription (Stat) signaling pathway. I hypothesized that P4 alters Jak/Stats through Pgrmc1 regulation of one or more Jak or Stat molecules and then performed a set of in vitro and in vivo studies to test this. I transfected N42 cells with either scramble or Pgrmc1 siRNA followed by treatment with either ethanol vehicle control or 10 nM P4 and measured Jak1, Jak2, Stat3, Stat5a, Stat5b, and Stat6 mRNA levels via quantitative polymerase chain reaction (QPCR). Jak1 and Jak2 mRNAs increased with P4 treatments, and this upregulation required Pgrmc1. Silencing Pgrmc1 in the cells also produced an increase in Jak1 and Jak2 mRNA, suggesting that Pgrmc1 constitutively suppressed jak1 and jak2 in the absence of P4. None of the Stats were significantly regulated by P4 or Pgrmc1 silencing. To determine how Pgrmc1 regulates Jak/Stat in vivo, I took AVPV microdissections from Pgrmc1 and Pgrmc2 double conditional knockout (DCKO) mice and looked at gene expression of jak/stat. Transcript levels of Jak2, but not Jak1, were severely downregulated in the DCKO animals and Stat mRNAs were not significantly changed. Discrepancies from in vitro and in vivo data prompted me to analyze the role of the class II progestin and adipoQ (Paqr) receptors in Jak/Stat signaling. P4 treatments and siRNA experiments in N42 cells showed that Paqr8, but not Paqr7, was required for P4 upregulation of Jak1 and Jak2 mRNAs. Overall, these findings show that Pgrmc1 regulates Jak1 and Jak2 synthesis in a P4-dependent and -independent manner that requires interaction with Paqr8.
La Imposible Serenidad de Michi Panero. Una Historia y Análisis de El Desencanto, Documental Creativo en el Tiempo de la Transición
Creators: name: Asuncion Benedito, Albert
Publisher: name: University of Massachusetts Amherst
Year: 2015

description: El Desencanto es una pelicula de tipo documental creativo dirigida por Jaime Chavarri en 1976 que retrata a la familia Panero. Por su tematica y estetica contrasta con la ideologia franquista, y fue leida como un simbolo de su tiempo. A traves del analisis de sus personajes y distintas obras de ese periodo historico, este trabajo trata de analizar este componente simbolico y ofrece una lectura politica de la obra.
Analysis of Parametric Oscillatory Instability in Power Recycled LIGO Interferometer
Creators: name: Braginsky, V. B.
name: Strigin, S. E.
name: Vyatchanin, S. P.
Publisher: name: arXiv
Year: 2002
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We present the analysis of a nonlinear effect of parametric oscillatory instability in power recycled LIGO interferometer with the Fabry-Perot (FP) cavities in the arms. The basis for this effect is the excitation of the additional (Stokes) optical mode and the mirror elastic mode, when the optical energy stored in the main FP cavity main mode exceeds the certain threshold and the frequencies are related so that sum of frequencies of Stokes and elastic modes are approximately equal to frequencyof main mode. The presence of anti-Stokes modes (with frequency approximately equal to sum of frequencies of main and elastic modes) can depress parametric instability. However, it is very likely that the anti-Stokes modes will not compensate the parametric instability completely.
description: 9 pages, 2 figures. submitted to Physics Letters A
The effect of exercise and caloric restriction on cardiac NF-kB signaling and inflammation in Otsuka Long-Evans Tokushima Fatty (OLETF) rats
Creators: name: Baez, Angel E
Publisher: name: University of Massachusetts Amherst
Year: 2016

description: ABSTRACT
Introduction: Cardiometabolic syndrome is considered a chronic low-grade inflammatory condition that affects various organs and tissues. Individuals with type 2 diabetes mellitus (T2DM) and obesity are at an increased risk for developing the cardiometabolic syndrome and have greater rates of cardiovascular disease (CVD). These conditions are also associated with increased systemic and local inflammation and greater expression of pro-inflammatory markers such as monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor-α (TNF-α), and interleukin 1β (IL-1β) in many tissues. The heart is adversely affected by the inflammation and metabolic changes induced by diabetes and obesity. Nuclear transcription factor kappa B (NF-κB) activity is known to be related to inflammation and cytokine production. However, there is limited information on whether NF-κB signaling and inflammation play a role in early cardiac pathogenesis related to obesity and diabetes and whether lifestyle changes known to prevent or treat these diseases are effective in the heart. Purpose: Therefore, the purpose of this study was to compare the effect of exercise (EX) and caloric restriction (CR) to alter NF-κB signaling, inflammation, and markers of cardiac dysfunction in the heart of 20-week old Otsuka Long Evans Tokushima (OLETF) rats. Methods: Hearts of male 20 week old OLETF rats from a previous study (Crissey et al., 2014) were collected for gene expression (RT-PCR), NF-κB activity, and markers of inflammation and immune cell infiltration. Results: There were no significant differences detected in markers of cardiac dysfunction including, α-MHC, β-MHC, ANP, BNP, COL1, COL3 (all p>0.05). Second, 1-way ANOVA showed that there was trend for an overall effect of group (p=0.07) on
NF-κB activation where CR tended to be greater compared to SED and WR (p=0.06). Finally, there were no significant differences between groups in inflammatory and immune cell markers; CD4, F4/80, CD68, IL-1β, MCP-1, TGFB1, and TNF-α (all p>0.05). Conclusion: This study shows that at 20 weeks, a time when OLETF animals exhibit characteristics of the metabolic syndrome such as hypertension, mild obesity, and increased insulin resistance, EX and CR do not reduce markers of cardiac dysfunction and inflammation, potentially because inflammation does not influence the heart at this early time period in the development of the disease. Further, the trend of greater NF-κB activity in CR compared to EX and SED, needs further exploration.
Curvature-Tilt Theories of Lipid Membranes
Creators: name: Terzi, Mustafa Mert
Publisher: name: Carnegie Mellon University
Year: 2019
Subjects: subject: 20399 Classical Physics not elsewhere classified
subject: FOS: Physical sciences

description: On mesoscopic scales lipid membranes are well described by continuum theories whose main ingredients are the curvature of a membrane’s reference surface and the tilt of its lipid constituents. In particular, Hamm and Kozlov [Eur. Phys. J. E 3, 323 (2000)] showed how to systematically
derive such a tilt-curvature Hamiltonian, based on the elementary assumption of a thin fluid elastic sheet experiencing internal lateral pre-stress. Performing a dimensional reduction, they not only derived the basic form of the effective surface Hamiltonian, but also made connections between the trans-membrane moments of lower-level material parameters and the emergent elastic
couplings of surface energy. In the present thesis we argue, though, that their derivation unfortunately missed a coupling term between curvature and tilt. The origin of this term is the change of transverse distances due to the variation in the curvature along the membranes. This change gives rise to a contribution to the energy which was believed to be small, but nevertheless ends up contributing at the same (quadratic) order as other terms in their Hamiltonian. We show the immediate consequences of this novel coupling term by by deriving the monolayer and bilayer
Euler-Lagrange equations for the tilt, as well as the power spectra of shape, tilt, and director fluctuations.
We also obtain a novel set of terms, quadratic in both curvature and tilt, of which only two were part of the quadratic theory. These biquadratics manifest as geometry-dependent corrections to the tilt modulus, converting it into a position-dependent tilt modulus tensor. For typical
material parameters, the resulting effective tilt modulus softens compared to the bare one, except within a small off-center domain of curvatures near the flat state. For sufficiently large curvatures, set by the characteristic length of tilt decay, the effective modulus even becomes negative.
We show that biquadratics matter for strongly curved geometries, such as open edges, triple line junctions, fusion stalks, and even bicontinuous phases, and as an illustration we calculate the line tension of edges and junctions.
System Integration and Control Design of a Maglev Platform for Space Vibration Isolation
Creators: name: Gong, Zhaopei
name: Ding, Liang
name: Yue, Honghao
name: Gao, Haibo
name: Liu, Rongqiang
name: Deng, Zongquan
name: Lu, Yifan
Publisher: name: arXiv
Year: 2019
Subjects: subject: Systems and Control (eess.SY)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Micro-vibration has been a dominant factor impairing the performance of scientific experiments which are expected to be deployed in a micro-gravity environment such as Spacelab. The micro-vibration has a serious impact on scientific experiments requiring a quasi-static environment. Therefore, we proposed a maglev vibration isolation platform (MVIP) operating in six degrees of freedom (DOF) to fulfill the environmental requirements. In view of non-contact and large stroke requirements for micro-vibration isolation, an optimization method was utilized to design the actuator. Mathematical models of the actuator's remarkable nonlinearity were established so that its output can be compensated according to floater's varying position and the system's performance may be satisfied. Furthermore, aiming to adapt to an energy-limited environment such as Spacelab, an optimum allocation scheme was put forward. Considering the actuator's nonlinearity, accuracy and minimum energy-consumption can be obtained simultaneously. In view of operating in six DOF, methods for nonlinear compensation and system decoupling were discussed, the necessary controller was also presented. Simulation and experiments validate the system's performance. With a movement range of 10x10x8 mm and rotations of 200 mrad, the decay ratio of -40 dB/Dec between 1-10 Hz was obtained under closed-loop control.
description: A preprint version
BBGKY Dynamics: from Localization to Pattern Formation
Creators: name: Fedorova, Antonina N.
name: Zeitlin, Michael G.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: Mathematical Physics (math-ph)
subject: Pattern Formation and Solitons (nlin.PS)
subject: FOS: Physical sciences

description: A fast and efficient numerical-analytical approach is proposed for modeling complex behaviour in the BBGKY--hierarchy of kinetic equations. Our calculations are based on variational and multiresolution approaches in the basis of polynomial tensor algebras of generalized coherent states/wavelets. We construct the representation for hierarchy of reduced distribution functions via the multiscale decomposition in highly-localized eigenmodes. Numerical modeling shows the creation of various internal structures from localized modes, which are related to localized or chaotic type of behaviour and the corresponding patterns (waveletons) formation. The localized pattern is a model for energy confinement state (fusion) in plasma.
description: 14 pages, 3 figures, ws-procs9x6.cls, presented at Workshop "Progress in Nonequilibrium Greens Functions", Dresden, Germany, August 19-23, 2002
Sedimentological Records and Numerical Simulations of the C.E. 1707 Hōei Tsunami in Southwestern Japan
Creators: name: Baranes, Hannah
Publisher: name: University of Massachusetts Amherst
Year: 2015

description: A tsunami generated by the C.E. 1707 Hōei earthquake is largely thought to be the flood event of record for southwestern Japan, yet historical documentation of the event is scarce.  This is particularly true in northwestern Shikoku within the Bungo Channel, where significant inconsistencies exist between historical records and model-derived tsunami heights. To independently assess flooding from the C.E. 1707 Hōei tsunami in the context of the region’s long-term flooding history, we present complementary reconstructions of extreme coastal inundation from three back-barrier lakes in the northern Bungo Channel: Lake Ryuuoo, Lake Amida, and Lake Kamega.  At all sites, the most prominent marine overwash deposit of the past ~1,000 years, as defined by grain size, density, and geochemical indicators, is consistent with the timing of the 1707 tsunami, providing strong evidence that the event caused the most significant flooding of the last millennium in this region.  At Lake Ryuuoo, modern barrier beach elevations and grain sizes in the tsunami’s resultant deposit provide ~4 m as the first physically based height constraint for the 1707 tsunami in the northern Bungo Channel. 
Around 1,000 years ago, a concurrent and abrupt transition in lithology observed at all three sites is also consistent with rapid, regional geomorphic change.  At Lake Ryuuoo, a marine overwash deposit comparable to the 1707 deposit directly overlies this transition.  A 1,000-year-old lithological transition or deposit has not been observed at sites closer to the mouth of the Bungo Channel, suggesting that the deposit in Lake Ryuuoo is more consistent with a tsunami generated by local seismicity along the Japan Median Tectonic Line than with a Nankai Trough-derived tsunami.  Our findings are significant in that they provide three new millennial-scale tsunami inundation reconstructions for a relatively understudied region of Japan, along with the first physically based height constraint for the Hōei tsunami in the northern Bungo Channel.
Dynamically turning off interactions in a two component condensate
Creators: name: Jaksch, D.
name: Cirac, J. I.
name: Zoller, P.
Publisher: name: arXiv
Year: 2001
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We propose a mechanism to change the interaction strengths of a two component condensate. It is shown that the application of pi/2 pulses allows to alter the effective interspecies interaction strength as well as the effective interaction strength between particles of the same kind. This mechanism provides a simple method to transform spatially stable condensates into unstable once and vice versa. It also provides a means to store a squeezed spin state by turning off the interaction for the internal states and thus allows to gain control over many body entangled states.
description: 7 pages 5 figures, symbols changed, minor changes, to appear in Phys. Rev. A
Study of the $ππ$ mass spectra in the process $e^+e^- \to π^+π^-π^0$ at $\sqrt[]{s} \simeq 1020$ MeV
Creators: name: Achasov, M. N.
name: Aulchenko, V. M.
name: Beloborodov, K. I.
name: Berdyugin, A. V.
name: Bogdanchikov, A. G.
name: Bozhenok, A. V.
name: Bukin, A. D.
name: Bukin, D. A.
name: Burdin, S. V.
name: Dimova, T. V.
name: Druzhinin, V. P.
name: Golubev, V. B.
name: Ivanchenko, V. N.
name: Ivanov, P. M.
name: Korol, A. A.
name: Korostelev, M. S.
name: Koshuba, S. V.
name: Otboev, A. V.
name: Pakhtusova, E. V.
name: Perevedentsev, E. A.
name: Salnikov, A. A.
name: Serednyakov, S. I.
name: Shary, V. V.
name: Shatunov, Yu. M.
name: Sidorov, V. A.
name: Silagadze, Z. K.
name: Vasiljev, A. V.
name: Velikzhanin, Yu. S.
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The invariant mass spectra of the $π^+π^-$ and $π^\pmπ^0$ pairs in the process $e^+e^- \to π^+π^-π^0$ were studied in the SND experiment at the VEPP-2M collider in the energy region $\sqrt[]{s} \simeq 1020$ MeV. These studies were based on about $0.5 \times 10^6$ experimental events. The spectra were analyzed in the framework of the vector meson dominance model. It was found that the experimental data can be described with $e^+e^- \to ρπ\to π^+π^-π^0$ transition only. Upper limit on the branching ratio of the $ϕ(1020)\toπ^+π^-π^0$ decay through intermediate states different from $ρπ$ was obtained at the 90 % confidence level: $B(ϕ\toπ^+π^-π^0)<6 \cdot 10^{-4}$. The $ρ$-meson mass and width which follow from the spectra analysis are $m_ρ=775.0\pm 1.3$ MeV, $Γ_ρ=150.4 \pm 3.0$ MeV. Neutral and charged $ρ$-mesons mass difference was found to equal $m_{ρ^\pm}-m_{ρ^0}=-1.3\pm2.3$ MeV. In the $π^+π^-$ mass spectrum the $ρ-ω$ interference was seen at two standard deviations level.
description: 22 pages REVTEX and 19 figures
NAKATKALANGAN QUVURLARNI STENDDA SINASH
Creators: name: Karabayev, Asatilla
name: G'anixonov, Abdullaxon
Publisher: name: Zenodo
Year: 2025

description: Oziq-ovqat, kimyo, neft va gazni qayta ishlash sohalarida keng tarqalgan issiqlik almashinish apparatlarining issiqlik almashinish jarayonlarini jadallashtirish maqsadida "Nakatka" qilish usulida tayyorlangan issiqlik almashinish trubasi tekis trubalardan qurilma yasash texnologiyasidan farq qilmaydi. Lekin, samarador trubali issiqlik almashinish qurilmasidagi nakatkali trubalarning umumiy uzunligi, tekis trubali qurilmanikidan kam bo‘ladi, ya’ni kamroq sarf bo‘ladi. Quvurning tashqi yuzasida nakatkalash yordamida hosil qilinadigan uyurmalar issiqlik tashuvchilarning quvurlararo oqimida issiqlik almashinuvini jadallashtiradi.
Technology adoption and the multiple dimensions of food security: the case of maize in Tanzania
Creators: name: Vigani, Mauro
name: Magrini, Emiliano
name: Vigani, Mauro
name: Magrini, Emiliano
Publisher: name: Unknown
Year: 2014
Subjects: subject: Crop Production/Industries
subject: Food Security and Poverty
subject: Technology adoption
subject: food security
subject: tanzania
subject: propensity score matching

description: The paper analyses the impact of adopting new agricultural technologies on the multiple dimensions of food security for maize farmers in Tanzania. Relying on matching techniques, we use a nationally representative dataset to estimate the causal effects of improved seeds and inorganic fertilizers on four dimensions: availability, access, utilization, and stability. We find an overall positive and significant impact on all the dimensions of food security even if substantial differences are observed. In particular, improved seeds show a stronger effect on food availability and access while inorganic fertilizers guarantee higher stability. In terms of utilization, both technologies increase the diet diversity while only improved seeds reduce the dependence on staple food. The study supports the idea that the relationship between new agricultural technologies and food security is a complex phenomenon which requires a deeper and more thorough investigation.
THE EVOLUTION OF THERMOTOLERANCE A CHARACTERIZATION OF A DIRECTIONALLY EVOLVED CYANOBACTERIUM
Creators: name: Bopp, nathen Emil
Publisher: name: University of Massachusetts Amherst
Year: 2015

description: Chaperone proteins are essential components in the maintenance and turnover of the proteome. Many chaperones play integral functions in the folding and unfolding of cellular substrates under many conditions, including heat stress. Most chaperones can be characterized into two categories; the typical ATP dependent chaperones and the ATP independent chaperones. One ATP independent chaperone class it the Small Heat Shock Proteins (sHSPs), which as molecular life vests and are thought to protect misfolding proteins from irreversible aggregation. One such organism, the cyanobacterium Synechocystis sp. PCC 6803, is an excellent model for the study and understanding of these proteins and their functions in vivo. The genome of Synechocystis encodes only one sHSP, Hsp16.6, and it has be shown to be essential for acquired thermotolerance. Two mutant derivatives of Hsp16.6 with single amino acid substitutions in the N-terminal arm (L9P and E25K) have loss-of-function phenotypes similar to knock out strains, but each has very different biochemical properties. The mutant L9P has an inability to interact with putative substrates during heat stress in vivo, while the mutant E25K appears unable to release substrates. Using a directed evolution approach, suppressors have been isolated that recover the lost thermotolerance of their respective parent strains, either L9P (16 suppressors) or E25K (10 suppressors). Illumina sequencing and comparative genomics have been used to identify alterations in the genomes of the suppressor strains in order to define genetic circuits involved in thermotolerance.
Dairy farm cost efficiency in leading milk producing regions in Poland
Creators: name: Sobczynski, Tadeusz
name: Klepacka, Anna M.
name: Revoredo-Giha, Cesar
name: Florkowski, Wojciech Jan
name: Sobczynski, Tadeusz
name: Klepacka, Anna M.
name: Revoredo-Giha, Cesar
name: Florkowski, Wojciech Jan
Publisher: name: Unknown
Year: 2014
Subjects: subject: Productivity Analysis
subject: FADN data
subject: FADN regions
subject: cost frontier function
subject: fixed effects
subject: inefficiency
subject: cost efficiency index

description: The cost efficiency of dairy farms was analyzed for two leading production areas in Poland, i.e., Wielkopolskie and Podlaskie Voivodships. The analysis suggests that dairy farms in Podlaskie Vovivodship appear to have a closer gap in cost inefficiency as compared to the most efficient farm than corresponding farms in Wielkopolskie Voivodship. Wielkopolskie voivodship has a relatively larger number of farms that could substantially improve their cost efficiency Than Podlaskie Voivodship. However, the cost efficiency index value calculation method permits only an indirect comparison across regions, while the FADN data does not account for likely labor cost differences between the regions.
Niche-Based Modeling of Japanese Stiltgrass (Microstegium vimineum) Using Presence-Only Information
Creators: name: Bush, Nathan
Publisher: name: University of Massachusetts Amherst
Year: 2015

description: The Connecticut River watershed is experiencing a rapid invasion of aggressive non-native plant species, which threaten watershed function and structure. Volunteer-based monitoring programs such as the University of Massachusetts’ OutSmart Invasives Species Project, Early Detection Distribution Mapping System (EDDMapS) and the Invasive Plant Atlas of New England (IPANE) have gathered valuable invasive plant data. These programs provide a unique opportunity for researchers to model invasive plant species utilizing citizen-sourced data. This study took advantage of these large data sources to model invasive plant distribution and to determine environmental and biophysical predictors that are most influential in dispersion, and to identify a suitable presence-only model for use by conservation biologists and land managers at varying spatial scales. This research focused on the invasive plant species of high interest - Japanese stiltgrass (Mircostegium vimineum). This was identified as a threat by U.S. Fish and Wildlife Service refuge biologists and refuge managers, but for which no mutli-scale practical and systematic approach for detection, has yet been developed. Environmental and biophysical variables include factors directly affecting species physiology and locality such as annual temperatures, growing degree days, soil pH, available water supply, elevation, closeness to hydrology and roads, and NDVI. Spatial scales selected for this study include New England (regional), the Connecticut River watershed (watershed), and the U.S. Fish and Wildlife, Silvio O. Conte National Fish and Wildlife Refuge, Salmon River Division (local). At each spatial scale, three software programs were implemented: maximum entropy habitat model by means of the MaxEnt software, ecological niche factor analysis (ENFA) using Openmodeller software, and a generalized linear model (GLM) employed in the statistical software R. Results suggest that each modeling algorithm performance varies among spatial scales. The best fit modeling software designated for each scale will be useful for refuge biologists and managers in determining where to allocate resources and what areas are prone to invasion. Utilizing the regional scale results, managers will understand what areas on a broad-scale are at risk of M. vimineum invasion under current climatic variables. The watershed-scale results will be practical for protecting areas designated as most critical for ensuring the persistence of rare and endangered species and their habitats. Furthermore, the local-scale, or fine-scale, analysis will be directly useful for on-the-ground conservation efforts. Managers and biologists can use results to direct resources to areas where M. vimineum is most likely to occur to effectively improve early detection rapid response (EDRR).
Proteomics of the Effect of Gemcitabine with Intravenous Omega-3 Fish Oil Infusion in Patients with Unresectable Pancreatic Adenocarcinoma
Creators: name: Franscois G. A. Robert Runau
Publisher: name: University of Leicester
Year: 2019
Subjects: Uncategorized

description: Background: Pancreatic cancer carries the poorest prognosis of all solid organ tumours. Administration of intravenous omega-3 fatty acid (n-3FA) in advanced pancreatic adenocarcinoma patients receiving gemcitabine chemotherapy in our institute shows disease stabilisation and improved progression free survival. Uncovering the underlying biological mechanisms that are responsible for these clinical effects will be investigated using high definition plasma proteomics.Methods: Plasma from patients with histologically confirmed un-resectable pancreatic adenocarcinoma, collected at baseline before treatment (Baseline group), after one-month treatment with intravenous gemcitabine and n-3FA (Treatment group) and intravenous gemcitabine only (Control group). Plasma was 99% immuno-depleted using Seppro IgY14 + Supermix columns, reduced, alkylated and tryptically digested. Two arms studies comparing Baseline vs Treatment groups and Treatment vs Control groups performed. Samples labelled with TMT-6plex, with a Quality Control sample comprising pooled samples. Combined TMT-labelled samples underwent high-pH reversed-phase fractionation. Fractions were injected into a QExactive-Orbitrap LC-MS/MS in triplicate and analysed on Proteome Discoverer 2.1 and Scaffold 4.7. Bioinformatic analysis was performed on Protein Centre for Gene Ontology Biological Process (GO-BP) enrichment analysis (p <0.05, Bonferroni corrected), Cytoscape for visualisation and KEGG pathway analysis. Selective Reaction Monitoring (SRM) analysis for verification were performed on selected peptides.Results: 3476 proteins identified. 125 proteins were significant markers of pancreatic cancer, including REG1A, LVVE and TFF. Anti-inflammatory markers (CRP, Haptoglobin and Serum Amyloid-A1) were reduced in the treatment group confirming the anti-inflammatory effects of n-3FA. GO-BP enrichment analysis showed angiogenesis downregulation, complement immune systems upregulation and epigenetic modifications on histones. KEGG pathway analysis identified direct action via the Pi3K-AKT pathway, with decreased HSP90 and increased inhibitory protein 14-3-3. Serum Amyloid-A1 significantly reduced (p<0.01) as a potential biomarker of efficacy for n-3FA.Conclusion: Administration of n-3FA and gemcitabine has anti-inflammatory, anti-angiogenic and pro-apoptotic effect via direct mechanism on cancer signalling pathways in patients with advanced pancreatic adenocarcinoma.
Molecular Interpretation of a Trigger for Controlling an Amine Isocyanate Polyurethane Reaction
Creators: name: Carrasquillo, Katherine V.
Publisher: name: University of Massachusetts Amherst
Year: 2015

description: The temperature profile needed to complete the reaction between the sodium-diamine complex and the isocyanate terminated prepolymer has been established. The sodium diamine complex has the advantage of blocking the nearly instantaneous reaction between the diamine and isocyanate from taking place until it is released at elevated temperatures. Because of its low melting temperature (~40 °C) and its low molecular weight (low viscosity), this chain extension reaction is not dependent on the participation of the prepolymer. Instead, the rate of reaction is dependent on the dissolution of the 4,4’-methylenedianiline (MDA) complex into the system. The dissolution of the MDA complex has been demonstrated to be strongly dependent on particle size. Both the plasticizer Bis(2-ethylhexyl) adipate and the quaternary ammonium compound found in soy lecithin play crucial roles for this reaction. The quaternary ammonium compound is crucial in the dissolution of the complexes. Although the plasticizer has been shown to dissolve the complex to a small extent, the principal role of the plasticizer is to disperse the complexes and to prevent their agglomeration. Other additives such as Dimethyl Sulfoxide (DMSO) have demonstrated to be highly efficient in dissolving the complex. However its effectiveness limits the mixing window needed before reaction take place, resulting in a disadvantage.
REBOUNDx: A Library for Adding Conservative and Dissipative Forces to Otherwise Symplectic N-body Integrations
Creators: name: Tamayo, Daniel
name: Rein, Hanno
name: Shi, Pengshuai
name: Hernandez, David M.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Symplectic methods, in particular the Wisdom-Holman map, have revolutionized our ability to model the long-term, conservative dynamics of planetary systems. However, many astrophysically important effects are dissipative. The consequences of incorporating such forces into otherwise symplectic schemes is not always clear. We show that moving to a general framework of non-commutative operators (dissipative or not) clarifies many of these questions, and that several important properties of symplectic schemes carry over to the general case. In particular, we show that explicit splitting schemes generically exploit symmetries in the applied external forces which often strongly suppress integration errors. Furthermore, we demonstrate that so-called `symplectic correctors' (which reduce energy errors by orders of magnitude at fixed computational cost) apply equally well to weakly dissipative systems and can thus be more generally thought of as `weak splitting correctors.' Finally, we show that previously advocated approaches of incorporating additional forces into symplectic methods work well for dissipative forces, but give qualitatively wrong answers for conservative but velocity-dependent forces like post-Newtonian corrections. We release REBOUNDx, an open-source C library for incorporating additional effects into REBOUND N-body integrations, together with a convenient Python wrapper. All effects are machine-independent and we provide a binary format that interfaces with the SimulationArchive class in REBOUND to enable the sharing and reproducibility of results. Users can add effects from a list of pre-implemented astrophysical forces, or contribute new ones.
description: Submitted. Paper repository: https://github.com/dtamayo/reboundxpaper, Library Documentation: https://reboundx.readthedocs.io/en/latest/
Wide-Field Survey of Dwarf Satellite Systems Around 10 Hosts in the Local Volume
Creators: name: Carlsten, Scott G.
name: Greco, Johnny P.
name: Beaton, Rachael L.
name: Greene, Jenny E.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present the results of an extensive search for dwarf satellite galaxies around 10 primary host galaxies in the Local Volume (D$
description: 37 pages, 13 figures, 12 tables. Comments welcome
Violation of energy-per-hadron scaling in a resonance matter
Creators: name: Bravina, L.
name: Faessler, Amand
name: Fuchs, C.
name: Lu, Z. -D.
name: Zabrodin, E.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Yields of hadrons, their average masses and energies per hadron at the stage of chemical freeze-out in (ultra)relativistic heavy-ion collisions are analyzed within the statistical model. The violation of the scaling / = 1 GeV observed in Au+Au collisions at $\sqrt{s}$ = 130 AGeV is linked to the formation of resonance-rich matter with a considerable fraction of baryons and antibaryons. The rise of the energy-per-hadron ratio in baryon-dominated matter is discussed. A violation of the scaling condition is predicted for a very central zone of heavy-ion collisions at energies around 40 AGeV.
description: 5 pages incl. 3 figures and 2 tables, to be published in Phys. Rev. C
Aculops propinquae Xue & Zhang 2008, comb. nov.
Creators: name: Xue, Xiao-Feng
name: Zhang, Zhi-Qiang
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Eriophyidae
Aculops
Aculops propinquae

description: Aculops propinquae (Manson, 1984), comb. nov.
 Pedaculops propinquae Manson, 1984a: 59–60.
 Pedaculops propinquae; Amrine & Stansy, 1994: 241.
 Material examined. 6 females, from Coprosma propinqua (Rubiaceae), Birdlings Flat, Mid-Canterbury, New Zealand, 17 November 1999, coll. N.A. Martin. Specimens deposited in NZAC.
 Host. Coprosma propinqua (Rubiaceae).
 Relation to host. Witches broom.
 Distribution. Dunedin, Mid-Canterbury (Birdlings Flat).
 Additional Coprosma propinqua bushes with typical witches broom were collected and deposited in NZAC by N.A. Martin: Coopers Creek, Oxford Forest, Mid-Canterbury, New Zealand, January 18, 2004; Lake Pearson, Mid-Canterbury, New Zealand, May 11, 2005.
 Remarks. Amrine (1996) and Amrine et al. (2003) assigned Pedaculops as a synonym of Aculops. Manson (1984a) distinguished Pedaculops from Aculops mainly by the second rays of empodium arise direct from the tarsus rather than from the main stem.
description: Published as part of Xue, Xiao-Feng & Zhang, Zhi-Qiang, 2008, New Zealand Eriophyoidea (Acari: Prostigmata): an update with descriptions of one new genus and six new species, pp. 1-32 in Zootaxa 1962 (1) on page 22, DOI: 10.11646/zootaxa.1962.1.1, http://zenodo.org/record/5241647
Cooperatively enhanced reactivity and 'stabilitaxis' of dissociating oligomeric proteins
Creators: name: Agudo-Canalejo, Jaime
name: Illien, Pierre
name: Golestanian, Ramin
Publisher: name: arXiv
Year: 2019
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Physical sciences

description: Many functional units in biology, such as enzymes or molecular motors, are composed of several subunits that can reversibly assemble and disassemble. This includes oligomeric proteins composed of several smaller monomers, as well as protein complexes assembled from a few proteins. By studying the generic spatial transport properties of such proteins, we investigate here whether their ability to reversibly associate and dissociate may confer them a functional advantage with respect to non-dissociating proteins. In uniform environments with position-independent association-dissociation, we find that enhanced diffusion in the monomeric state coupled to reassociation into the functional oligomeric form leads to enhanced reactivity with distant targets. In non-uniform environments with position-dependent association-dissociation, caused e.g. by spatial gradients of an inhibiting chemical, we find that dissociating proteins generically tend to accumulate in regions where they are most stable, a process that we term 'stabilitaxis'.
description: Main Text (9 pages, 3 figures) plus Supplementary Information (7 pages, 7 figures)
Development of Nanoemulsion-based Delivery Systems for Evaluation of Triglycerides Bioactivity in Caernohabditis Elegans
Creators: name: Colmenares, Jose D
Publisher: name: University of Massachusetts Amherst
Year: 2015

description: Digestion and absorption of bioactive free fatty acids have been studied using the nematode Caernohabditis elegans (C. elegans). However, fatty acids mostly occur in foods in the form of triglycerides, which are highly hydrophobic molecules with low water-solubility, thereby making it difficult to study the fate of ingested fatty acids in C. elegans. The purpose of this research was to develop a method to deliver hydrophobic bioactives, including triglycerides, into C. elegans. Nanoemulsions containing triglyceride nanoparticles were prepared by sonication, and nanoparticle ingestion was confirmed by optical and confocal microscopy, and quantified by spectrometry. Changes in fatty acid composition were measured to confirm the absorption of triglycerides delivered as nanoparticles. Nanoparticles with a wide range of particle diameters (40 to 500 nm) were ingested by C. elegans. The ingested triglyceride amount was dependent on the size and concentration of the nanoparticles, but the fatty acid composition of C. elegans was not significantly changed by dietary triglycerides. Nanoemulsion based-delivery systems enable C. elegans to be used for evaluation of hydrophobic bioactives and may provide a useful tool for testing their biological activities.
The burden of cardio-cerebrovascular disease and lung cancer attributable to PM2.5 for 2009, Guangzhou: a retrospective population-based study
Creators: name: Lin, Xiao
name: Liao, Yu
name: Hao, Yuantao
Publisher: name: Taylor & Francis
Year: 2018
Subjects: Medicine
Biotechnology
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Science Policy

description: Particulate matter pollution has become a widely-concerned issue in public health and led to a substantial loss of health. The study reports relationship between particulate matter with aerodynamic diameter <2.5 µm (PM2.5) and years of life lost (YLL) in Guangzhou. A retrospective burden analysis on annual mean PM2.5 data was conducted. Data on annual mortality were collected for 2009, from the Health Department of Guangzhou. Data on particulate matter were collected for period 2006–2009. Comparative risk assessment and exposure-response function were used to estimate attributable YLL. The exposure to PM2.5 was associated with a total of 454.6 YLLs (95% uncertainty interval 449.0–460.1) per 100,000 people in 2009. This study has confirmed the substantial adverse health effects of PM2.5 exposure in population with cardio-cerebrovascular disease and lung cancer. This study highlights the need to reduce ambient particulate pollution for better environmental health and lower burden of disease.
Evaluating an Immersive Space-Time Cube Geovisualization for Intuitive Trajectory Data Exploration
Creators: name: Filho, Jorge A. Wagner
name: Stuerzlinger, Wolfgang
name: Nedel, Luciana
Publisher: name: arXiv
Year: 2019
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: Graphics (cs.GR)
subject: FOS: Computer and information sciences
subject: H.5.1

description: A Space-Time Cube enables analysts to clearly observe spatio-temporal features in movement trajectory datasets in geovisualization. However, its general usability is impacted by a lack of depth cues, a reported steep learning curve, and the requirement for efficient 3D navigation. In this work, we investigate a Space-Time Cube in the Immersive Analytics domain. Based on a review of previous work and selecting an appropriate exploration metaphor, we built a prototype environment where the cube is coupled to a virtual representation of the analyst's real desk, and zooming and panning in space and time are intuitively controlled using mid-air gestures. We compared our immersive environment to a desktop-based implementation in a user study with 20 participants across 7 tasks of varying difficulty, which targeted different user interface features. To investigate how performance is affected in the presence of clutter, we explored two scenarios with different numbers of trajectories. While the quantitative performance was similar for the majority of tasks, large differences appear when we analyze the patterns of interaction and consider subjective metrics. The immersive version of the Space-Time Cube received higher usability scores, much higher user preference, and was rated to have a lower mental workload, without causing participants discomfort in 25-minute-long VR sessions.
description: IEEE VIS InfoVis 2019 (Transactions on Visualization and Computer Graphics)
Additional file 1 of Effectiveness and cost-effectiveness of the PLAN-A intervention, a peer led physical activity program for adolescent girls: results of a cluster randomised controlled trial
Creators: name: Jago, Russell
name: Tibbitts, Byron
name: Willis, Kathryn
name: Sanderson, Emily
name: Kandiyali, Rebecca
name: Reid, Tom
name: Kipping, Ruth R
name: Campbell, Rona
name: MacNeill, Stephanie J
name: Hollingworth, William
name: Sebire, Simon J.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1:
Influencing factors of clinical efficacy of roxadustat among hemodialysis patients
Creators: name: Wu, Wenhui
name: Hu, Nan
name: Li, Xiurong
name: Di, Jia
name: Zhou, Hua
name: Niu, Hongyan
name: Yang, Min
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Science Policy
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: To explore independent influencing factors for clinical efficacy of roxadustat in hemodialysis patients. Hemodialysis patients treated with roxadustat were enrolled. The plasma trough concentrations of roxadustat were measured using liquid chromatography–tandem mass spectrometry (LC–MS/MS). A multiple logistic regression model was established to determine the factors that affect clinical efficacy of roxadustat in patients undergoing hemodialysis. A total of 67 hemodialysis patients were enrolled in the study. The results showed that age, blood trough concentration of roxadustat, and baseline hemoglobin (Hb) level were independent factors of clinical efficacy of roxadustat (OR = 1.06, p = .025 for age; OR = 1.001, p = .037 for plasma concentration; and OR = 0.941, p = .003 for baseline Hb), with an AUC score of 0.859. Age, blood trough concentration of roxadustat, and baseline Hb level were independent influencing factors of the response to roxadustat in hemodialysis patients.
Factors associated with post-hospitalization dialysis dependence in ECMO patients who required continuous renal replacement therapy
Creators: name: Palacios, Carlos Rodrigo Franco
name: Hoxhaj, Rudiona
name: Thigpen, Catlyn
name: Jacob, Jeffrey
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Science Policy

description: This single center retrospective study aimed to describe the variables associated with outpatient dialysis dependence in extracorporeal membrane oxygenation (ECMO) patients who needed continuous renal replacement therapy (CRRT) for acute kidney injury (AKI) during their hospitalization. Retrospective study of patients who required ECMO-CRRT. Between the years of 2016 and 2022, 202 patients required ECMO-CRRT. One hundred and six patients (52.5%) survived their hospitalization and were followed up for a median of 391 [133, 1005] days. Eighty-one patients (76.5%) recovered kidney function and were dialysis-free before hospital discharge. Twenty-five patients (23.5%) were hemodialysis-dependent after hospitalization. On multivariate regression analysis, hyperlipidemia (odds ratio, OR 6.08 [1.67–22]) and CRRT duration (OR 1.09 [1.03–1.15]) were associated with the need for dialysis post-hospitalization. In this group, 16 patients eventually became dialysis-free, after a median of 49 [34.7, 78.5] days. These patients had a higher median baseline glomerular filtration rate (GFR) compared to those who never recovered renal function (93 mL/min/1.73 m2 [82.4, 104.3] vs. 63.8 mL/min/1.73 m2 [37.9, 83], p = .009). Their follow-up GFR was lower compared to those who recovered renal function before hospital discharge; (87 mL/min/1.73 m2 [68.2, 98.9] vs. 99 mL/min/1.73 m2 [79, 118], p = .07). AKI requiring CRRT was associated with high mortality in patients receiving ECMO. Nonetheless, most ECMO survivors became dialysis-free before hospital discharge. Variables associated with the need for outpatient dialysis included hyperlipidemia and prolonged need for CRRT during hospitalization.
Additional file 1 of Interviewing children: the impact of the COVID-19 quarantine on children’s perceived psychological distress and changes in routine
Creators: name: G. Segre
name: R. Campi
name: F. Scarpellini
name: A. Clavenna
name: M. Zanetti
name: M. Cartabia
name: Bonati, M.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. STROBE checklist. STROBE: The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: guidelines for reporting observational studies, 22 item checklist