cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Are Milky-Way-like galaxies like the Milky Way? A view from SDSS-IV/MaNGA
Creators: name: Zhou, Shuang
name: Aragón-Salamanca, Alfonso
name: Merrifield, Michael
name: Andrews, Brett H.
name: Drory, Niv
name: Lane, Richard R.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: In this paper, we place the Milky Way (MW) in the context of similar-looking galaxies in terms of their star-formation and chemical evolution histories. We select a sample of 138 Milky-Way analogues (MWAs) from the SDSS-IV/MaNGA survey based on their masses, Hubble types, and bulge-to-total ratios. To compare their chemical properties to the detailed spatially-resolved information available for the MW, we use a semi-analytic spectral fitting approach, which fits a self-consistent chemical-evolution and star-formation model directly to the MaNGA spectra. We model the galaxies' inner and outer regions assuming that some of the material lost in stellar winds falls inwards. We also incorporate chemical enrichment from type II and Ia supernovae to follow the alpha-element abundance at different metallicities and locations. We find some MWAs where the stellar properties closely reproduce the distribution of age, metallicity, and alpha enhancement at both small and large radii in the MW. In these systems, the match is driven by the longer timescale for star formation in the outer parts, and the inflow of enriched material to the central parts. However, other MWAs have very different histories. These divide into two categories: self-similar galaxies where the inner and outer parts evolve identically; and centrally-quenched galaxies where there is very little evidence of late-time central star formation driven by material accreted from the outer regions. We find that, although selected to be comparable, there are subtle morphological differences between galaxies in these different classes, and that the centrally-quenched galaxies formed their stars systematically earlier.
description: 16 pages, 9 figures, MNRAS accepted version
The CUL1 C-Terminal Sequence and ROC1 Are Required for Efficient Nuclear Accumulation, NEDD8 Modification, and Ubiquitin Ligase Activity of CUL1
Creators: name: Zhang, Y.
name: Ohta, T.
name: Furukawa, M.
name: McCarville, J.
name: Xiong, Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: Members of the cullin and RING finger ROC protein families form heterodimeric complexes to constitute a potentially large number of distinct E3 ubiquitin ligases. We report here that the highly conserved C-terminal sequence in CUL1 is dually required, both for nuclear localization and for modification by NEDD8. Disruption of ROC1 binding impaired nuclear accumulation of CUL1 and decreased NEDD8 modification in vivo but had no effect on NEDD8 modification of CUL1 in vitro, suggesting that ROC1 promotes CUL1 nuclear accumulation to facilitate its NEDD8 modification. Disruption of NEDD8 binding had no effect on ROC1 binding, nor did it affect nuclear localization of CUL1, suggesting that nuclear localization and NEDD8 modification of CUL1 are two separable steps, with nuclear import preceding and required for NEDD8 modification. Disrupting NEDD8 modification diminishes the IκBα ubiquitin ligase activity of CUL1. These results identify a pathway for regulation of CUL1 activity—ROC1 and the CUL1 C-terminal sequence collaboratively mediate nuclear accumulation and NEDD8 modification, facilitating assembly of active CUL1 ubiquitin ligase. This pathway may be commonly utilized for the assembly of other cullin ligases.
CNOT gates for fluxonium qubits via selective darkening of transitions
Creators: name: Nesterov, Konstantin N.
name: Wang, Chen
name: Manucharyan, Vladimir E.
name: Vavilov, Maxim G.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We analyze the cross-resonance effect for fluxonium circuits and investigate a two-qubit gate scheme based on selective darkening of a transition. In this approach, two microwave pulses at the frequency of the target qubit are applied simultaneously with a proper ratio between their amplitudes to achieve a controlled-NOT operation. We study in detail coherent gate dynamics and calculate gate error. With nonunitary effects accounted for, we demonstrate that gate error below $10^{-4}$ is possible for realistic hardware parameters. This number is facilitated by long coherence times of computational transitions and strong anharmonicity of fluxoniums, which easily prevents excitation to higher excited states during the gate microwave drive.
description: 13 pages, 5 figures; published version
Transcriptional Scaffold: CIITA Interacts with NF-Y, RFX, and CREB To Cause Stereospecific Regulation of the Class II Major Histocompatibility Complex Promoter
Creators: name: Chin, K.-C.
name: Li, G.
name: Zhu, X.-S.
name: Linhoff, M. W.
name: Ting, J. P.-Y.
name: Maity, S. N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: Scaffold molecules interact with multiple effectors to elicit specific signal transduction pathways. CIITA, a non-DNA-binding regulator of class II major histocompatibility complex (MHC) gene transcription, may serve as a transcriptional scaffold. Regulation of the class II MHC promoter by CIITA requires strict spatial-helical arrangements of the X and Y promoter elements. The X element binds RFX (RFX5/RFXANK-RFXB/RFXAP) and CREB, while Y binds NF-Y/CBF (NF-YA, NF-YB, and NF-YC). CIITA interacts with all three. In vivo analysis using both N-terminal and C-terminal deletion constructs identified critical domains of CIITA that are required for interaction with NF-YB, NF-YC, RFX5, RFXANK/RFXB, and CREB. We propose that binding of NF-Y/CBF, RFX, and CREB by CIITA results in a macromolecular complex which allows transcription factors to interact with the class II MHC promoter in a spatially and helically constrained fashion.
title: Les médecines complémentaires
title: un moyen d'atteindre le bien-être dans la maladie
titleType: Subtitle
Creators: name: Blümel Rufenacht, Katharina
name: Chaves Rosa, Nely
name: Rouiller, Murielle
Publisher: name: Unknown
Year: 0
Subjects: subject: médecine complémentaire
subject: bien-être
subject: vie quotidienne
subject: maladie

description: Problématique : incidence du cancer en augmentation, constat d’utilisation de médecines complémentaires par des patients, dont sans que ceux-ci n’en réfèrent à leurs soignants. Sachant qu’il a des interactions possibles entre les médecines complémentaires et le traitement conventionnel, nous notons un manque de connaissances de la part des infirmières concernant les CAM.
description: Mémoire de bachelor : Haute école de la santé La Source, 2014
Classical off-shell currents
Creators: name: Comberiati, Francesco
name: de la Cruz, Leonardo
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We consider tree-level off-shell currents of two massive particles and $n$ massless bosons in the classical limit, which can be fused into the classical limit of $n+2$ scattering amplitudes. We show that dressing up the current with coherent wave-functions associated with the massive particles leads to the recently proposed Worldline Quantum Field Theory (WQFT) path integral. The currents thus constructed encode solutions of classical equations of motion so they can be applied to contexts where the classical limit is relevant, including hard thermal loops. We give several examples of these currents in scalar, gauge and gravitational theories.
description: 28 pages, v2: clarifications in Sec.2, references added, typos fixed, matches published version
title: Adolescents atteints de fibrose kystique et adhésion thérapeutique
title: entre vent de liberté et traitement à gérer
titleType: Subtitle
Creators: name: Bornoz, Nicolas
name: Besson, Pauline
Publisher: name: Unknown
Year: 0
Subjects: subject: adolescent
subject: fibrose kystique
subject: adhésion thérapeutique

description: La fibrose kystique est une maladie héréditaire touchant un enfant sur 1800-2000 en Suisse (Société suisse pour la mucoviscidose, 2010). L'augmentation de l'espérence de vie permise par les avancées thérapeutiques fait que de plus en plus d'adolescents doivent apprendre à vivre avec cette maladie. Or, les adolescents traversent une période de vie durant laquelle le désir d'autonomie et le besoin de soutien s'affrontent, ce qui peut mener à des tensions, voire des conflits, pouvant se manifester par le refus de se conformer aux traitements.
description: Mémoire de bachelor : Haute école de la santé La Source, 2014
A Note on the Misinterpretation of the US Census Re-identification Attack
Creators: name: Francis, Paul
Publisher: name: arXiv
Year: 2022
Subjects: subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences

description: In 2018, the US Census Bureau designed a new data reconstruction and re-identification attack and tested it against their 2010 data release. The specific attack executed by the Bureau allows an attacker to infer the race and ethnicity of respondents with average 75% precision for 85% of the respondents, assuming that the attacker knows the correct age, sex, and address of the respondents. They interpreted the attack as exceeding the Bureau's privacy standards, and so introduced stronger privacy protections for the 2020 Census in the form of the TopDown Algorithm (TDA). This paper demonstrates that race and ethnicity can be inferred from the TDA-protected census data with substantially better precision and recall, using less prior knowledge: only the respondents' address. Race and ethnicity can be inferred with average 75% precision for 98% of the respondents, and can be inferred with 100% precision for 11% of the respondents. The inference is done by simply assuming that the race/ethnicity of the respondent is that of the majority race/ethnicity for the respondent's census block. The conclusion to draw from this simple demonstration is NOT that the Bureau's data releases lack adequate privacy protections. Indeed it is the purpose of the data releases to allow this kind of inference. The problem, rather, is that the Bureau's criteria for measuring privacy is flawed and overly pessimistic.
description: PSD 2022
title: L'accompagnement par une infirmière spécialisée en cancer du sein
title: en quoi l'accompagnement proposé par l'infirmière spécialisée améliore la satisfaction des patientes atteinte de cancer du sein
titleType: Subtitle
Creators: name: Bajulaz, Anouck
name: Sommer, Anouck
Publisher: name: Unknown
Year: 0
Subjects: subject: cancer
subject: accompagnement
subject: femme
subject: sein
subject: image de soi
subject: rôle infirmier

description: Dans ce travail, nous nous intéressons à l’infirmière spécialisée dans le cancer du sein et à la satisfaction des femmes par rapport à l’accompagnement donné par ces infirmières. Notre question de recherche est la suivante : En quoi l’accompagnement proposé par l’infirmière spécialisée améliore la satisfaction des patientes atteintes de cancer du sein ?
description: Lausanne : Haute école de la santé La Source, 2014
A remark on the bound for the free energy of directed polymers in random environment in 1+2 dimension
Creators: name: Nakashima, Makoto
Publisher: name: arXiv
Year: 2014
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: We consider the behavior of the quantity $p(β)$; the free energy of directed polymers in random environment in $1+2$ dimension, where $β$ is inverse temperature. We know that the free energy is strictly negative when $β$ is not zero. In this paper, we will prove that $p(β)$ is bounded from above by $-\exp\left( -\frac{c_\varepsilon}{β^{2+\varepsilon}} \right)$ for small $β$, where $c_\varepsilon>0$ is a constant depending on $\varepsilon>0$. Also, we will suggest a strategy to get a sharper asymptotics.
Breakdown of bulk-projected isotropy in surface electronic states of topological Kondo insulator SmB$_6$(001)
Creators: name: Ohtsubo, Yoshiyuki
name: Nakaya, Toru
name: Nakamura, Takuto
name: Fèvre, Patrick Le
name: Bertran, François
name: Iga, Fumitoshi
name: Kimura, Shin-Ichi
Publisher: name: arXiv
Year: 2022
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The topology and spin-orbital polarization of two-dimensional (2D) surface electronic states have been extensively studied in this decade. One major interest in them is their close relationship with the parities of the bulk (3D) electronic states. In this context, the surface is often regarded as a simple truncation of the bulk crystal. Here we show breakdown of the bulk-related in-plane rotation symmetry in the topological surface states (TSSs) of the Kondo insulator SmB$_6$. Angle-resolved photoelectron spectroscopy (ARPES) performed on the vicinal SmB$_6$(001)-$p$(2$\times$2) surface showed that TSSs are anisotropic and that the Fermi contour lacks the fourfold rotation symmetry maintained in the bulk. This result emphasizes the important role of the surface atomic structure even in TSSs. Moreover, it suggests that the engineering of surface atomic structure could provide a new pathway to tailor various properties among TSSs, such as anisotropic surface conductivity, nesting of surface Fermi contours, or the number and position of van Hove singularities in 2D reciprocal space.
description: 24 pages 7 figures (4 for main text, 3 for supplementary information) and 1 supplementary table
Suppression of reconnection in polarized, thin magnetotail current sheets: 2D simulations and implications
Creators: name: An, Xin
name: Artemyev, Anton
name: Angelopoulos, Vassilis
name: Runov, Andrei
name: Lu, San
name: Pritchett, Philip
Publisher: name: arXiv
Year: 2022
Subjects: subject: Space Physics (physics.space-ph)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: Many in-situ spacecraft observations have demonstrated that magnetic reconnection in the Earth's magnetotail is largely controlled by the pre-reconnection current sheet configuration. One of the most important thin current sheet characteristics is the preponderance of electron currents driven by strong polarized electric fields, which are commonly observed in the Earth's magnetotail well before the reconnection. We use particle-in-cell simulations to investigate magnetic reconnection in the 2D magnetotail current sheet with a finite magnetic field component normal to the current sheet and with the current sheet polarization. Under the same external driving conditions, reconnection in a polarized current sheet is shown to occur at a lower rate than in a nonpolarized current sheet. The reconnection rate in a polarized current sheet decreases linearly as the electron current's contribution to the cross-tail current increases. In simulations with lower background temperature the reconnection electric field is higher. We demonstrate that after reconnection in such a polarized current sheet, the outflow energy flux is mostly in the form of ion enthalpy flux, followed by electron enthalpy flux, Poynting flux, ion kinetic energy flux and electron kinetic energy flux. These findings are consistent with spacecraft observations. Because current sheet polarization is not uniform along the magnetotail, our results suggest that it may slow down reconnection in the most polarized near-Earth magnetotail and thereby move the location of reconnection onset downtail.
description: 37 pages, 11 figures
Transient Expression of Cellular Polypyrimidine-Tract Binding Protein Stimulates Cap-Independent Translation Directed by Both Picornaviral and Flaviviral Internal Ribosome Entry Sites In Vivo
Creators: name: Sangar, D. V.
name: Chang, K. H.
name: Lemon, S. M.
name: Gosert, R.
name: Rijnbrand, R.
name: Yi, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: The regulation of cap-independent translation directed by the internal ribosome entry sites (IRESs) present in some viral and cellular RNAs is poorly understood. Polypyrimidine-tract binding protein (PTB) binds specifically to several viral IRESs. IRES-directed translation may be reduced in cell-free systems that are depleted of PTB and restored by reconstitution of lysates with recombinant PTB. However, there are no data concerning the effects of PTB on IRES-directed translation in vivo. We transfected cells with plasmids expressing dicistronic transcripts in which the upstream cistron encoded PTB or PTB deletion mutants (including a null mutant lacking amino acid residues 87 to 531). The downstream cistron encoded a reporter protein (chloramphenicol acetyltransferase [CAT]) under translational control of the poliovirus IRES which was placed within the intercistronic space. In transfected BS-C-1 cells, transcripts expressing wild-type PTB produced 12-fold more reporter protein than similar transcripts encoding the PTB null mutant. There was a 2.4-fold difference in CAT produced from these transcripts in HeLa cells, which contain a greater natural abundance of PTB. PTB similarly stimulated CAT production from transcripts containing the IRES of hepatitis A virus or hepatitis C virus in BS-C-1 cells and Huh-7 cells (37- to 44-fold increase and 5 to 5.3-fold increase, respectively). Since PTB had no quantitative or qualitative effect on transcription from these plasmids, we conclude that PTB stimulates translation of representative picornaviral and flaviviral RNAs in vivo. This is likely to reflect the stabilization of higher ordered RNA structures within the IRES and was not observed with PTB mutants lacking RNA recognition motifs located in the C-terminal third of the molecule.
Vav2 Activates Rac1, Cdc42, and RhoA Downstream from Growth Factor Receptors but Not beta 1 Integrins
Creators: name: Burridge, K.
name: Liu, B. P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: The Rho family of GTPases plays a major role in the organization of the actin cytoskeleton. These G proteins are activated by guanine nucleotide exchange factors that stimulate the exchange of bound GDP for GTP. In their GTP-bound state, these G proteins interact with downstream effectors. Vav2 is an exchange factor for Rho family GTPases. It is a ubiquitously expressed homologue of Vav1, and like Vav1, it has previously been shown to be activated by tyrosine phosphorylation. Because Vav1 becomes tyrosine phosphorylated and activated following integrin engagement in hematopoietic cells, we investigated the tyrosine phosphorylation of Vav2 in response to integrin-mediated adhesion in fibroblasts and epithelial cells. However, no tyrosine phosphorylation of Vav2 was detected in response to integrin engagement. In contrast, treating cells with either epidermal growth factor or platelet-derived growth factor stimulated tyrosine phosphorylation of Vav2. We have examined the effects of overexpressing either wild-type or amino-terminally truncated (constitutively active) forms of Vav2 as fusion proteins with green fluorescent protein. Overexpression of either wild-type or constitutively active Vav2 resulted in prominent membrane ruffles and enhanced stress fibers. These cells revealed elevated rates of cell migration that were inhibited by expression of dominant negative forms of Rac1 and Cdc42. Using a binding assay to measure the activity of Rac1, Cdc42, and RhoA, we found that overexpression of Vav2 resulted in increased activity of each of these G proteins. Expression of a carboxy-terminal fragment of Vav2 decreased the elevation of Rac1 activity induced by epidermal growth factor, consistent with Vav2 mediating activation of Rac1 downstream from growth factor receptors.
Integration-by-parts identities in FDR
Creators: name: Pittau, Roberto
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Four-dimensional renormalized (FDR) integrals play an increasingly important role in perturbative loop calculations. Thanks to them, loop computations can be performed directly in four dimensions and with no ultraviolet (UV) counterterms. In this paper I prove that integration-by-parts (IBP) identities can be used to find relations among multi-loop FDR integrals. Since algorithms based on IBP are widely applied beyond one loop, this result represents a decisive step forward towards the use of FDR in multi-loop calculations.
description: 13 pages
title: La douleur aux urgences
title: quelles interventions permettent à l'infirmière d'optimiser la prise en charge ?
titleType: Subtitle
Creators: name: Badan, Aurélie
name: Bouchard, Sara
Publisher: name: Unknown
Year: 0
Subjects: subject: douleur
subject: urgences
subject: évaluation
subject: rôle infirmier

description: La douleur est le principal motif d'admission aux urgences. Les spécificités de ce domaine font que les soignants rencontrent certains obstacles qui limitent la qualité de la prise en charge. L'infirmière joue un rôle déterminant dans le soulagement de la douleur et possède de nombreuses responsabilités quant à la qualité de la prise en charge.
description: Mémoire de bachelor : Haute école de la santé La Source, 2014
Super and massive AGB stars - IV. Final fates - Initial to final mass relation
Creators: name: Doherty, Carolyn L.
name: Gil-Pons, Pilar
name: Siess, Lionel
name: Lattanzio, John C.
name: Lau, Herbert H. B.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We explore the final fates of massive intermediate-mass stars by computing detailed stellar models from the zero age main sequence until near the end of the thermally pulsing phase. These super-AGB and massive AGB star models are in the mass range between 5.0 and 10.0 Msun for metallicities spanning the range Z=0.02-0.0001. We probe the mass limits M_up, M_n and M_mass, the minimum masses for the onset of carbon burning, the formation of a neutron star, and the iron core-collapse supernovae respectively, to constrain the white dwarf/electron-capture supernova boundary. We provide a theoretical initial to final mass relation for the massive and ultra-massive white dwarfs and specify the mass range for the occurrence of hybrid CO(Ne) white dwarfs. We predict electron-capture supernova (EC-SN) rates for lower metallicities which are significantly lower than existing values from parametric studies in the literature. We conclude the EC-SN channel (for single stars and with the critical assumption being the choice of mass-loss rate) is very narrow in initial mass, at most approximately 0.2 Msun. This implies that between ~ 2-5 per cent of all gravitational collapse supernova are EC-SNe in the metallicity range Z=0.02 to 0.0001. With our choice for mass-loss prescription and computed core growth rates we find, within our metallicity range, that CO cores cannot grow sufficiently massive to undergo a Type 1.5 SN explosion.
description: 15 pages, 7 figures, accepted for publication in MNRAS
Collection of case studies on academic career assessment - CoARA Working Group ACA
Creators: name: CoARA Working Group ACA
Publisher: name: Zenodo
Year: 2024
Subjects: CoARA
careers
reward
recognition
academic careers
research assessment

description: The CoARA Working Group on Reforming Academic Career Assessment (WG ACA) has developed a targeted mapping of initiatives on academic career assessment.

These files refer to a collection of case studies, which describe well-established international and national level initiatives for reforming research and academic career assessment.

Initiatives included in the case studies collection had an implementation plan targeted to all organisations conducting academic career assessments (recruitment, performance evaluation and/or career progression) within a country (national level) or irrespective of country (international). In addition, public documentation of the initiatives could be in any language, however in the case-study they need to be described in English.

A case-study template was used for describing the initiatives in a structured and comparable way. The following 11 case studies are included:

Initiative - name:

ANECA - Reforming research and academic careers assessment in Spain

CLACSO-FOLEC - Declaration of principles: a new research assessment towards a socially relevant science in Latin America and the Caribbean

CoARA - Coalition for Advancing Research Assessment (CoARA)

DORA - The San Francisco Declaration on Research Assessment (DORA)

EU Charter - The European Charter for Researchers

Finland - Good practice in researcher evaluation

Netherlands - Recognition & Rewards Programme

Norway - NOR-CAM – A toolbox for recognition and rewards in academic careers

OR4 - Open and Responsible Researcher Reward and Recognition (OR4)

UKRI - UKRI People and Teams Action Plan

YUFE4Postdocs - YUFE4Postdocs evaluation & selection procedure

A list of practical tools, which are part of the 11 initiatives described in the case studies, is also included.

Additional related materials include a survey on academic career assessment (zenodo.org/records/14548157) and lessons learned from the case studies and survey (zenodo.org/records/14548106).
A 36-Amino-Acid Region of CIITA Is an Effective Inhibitor of CBP: Novel Mechanism of Gamma Interferon-Mediated Suppression of Collagen  2(I) and Other Promoters
Creators: name: Ting, J. P.-Y.
name: Zhu, X.-S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: The class II transactivator (CIITA) is induced by gamma interferon (IFN-γ) and activates major histocompatibility complex class II; however, this report shows it suppresses other genes. An N-terminal 36 amino acids of CIITA mediates suppression of the collagen α2(I) promoter via binding to CREB-binding protein (CBP). Reconstitution of cells with CBP reverts this suppression. IFN-γ is known to inhibit collagen gene expression; to test if CIITA mediates this gene suppression, a mutant cell line defective in CIITA induction but not in the activation of STAT1/JAK/IRF-1 is studied. IFN-γ suppression of the collagen promoter and the endogenous gene is observed in the wild-type control but not in the mutant line. Suppression is restored when CIITA is introduced. Other targets of CIITA-mediated promoter suppression include interleukin 4, thymidine kinase, and cyclin D1.
Downregulation of CIITA Function by Protein Kinase A (PKA)-Mediated Phosphorylation: Mechanism of Prostaglandin E, Cyclic AMP, and PKA Inhibition of Class II Major Histocompatibility Complex Expression in Monocytic Lines
Creators: name: Harton, J. A.
name: Ting, J. P.-Y.
name: Li, G.
name: Zhu, X.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Prostaglandins, pleiotropic immune modulators that induce protein kinase A (PKA), inhibit gamma interferon induction of class II major histocompatibility complex (MHC) genes. We show that phosphorylation of CIITA by PKA accounts for this inhibition. Treatment with prostaglandin E or 8-bromo-cyclic AMP or transfection with PKA inhibits the activity of CIITA in both mouse and human monocytic cell lines. This inhibition is independent of other transcription factors for the class II MHC promoter. These same treatments also greatly reduced the induction of class II MHC mRNA by CIITA. PKA phosphorylation sites were identified using site-directed mutagenesis and phosphoamino acid analysis. Phosphorylation at CIITA serines 834 and 1050 accounts for the inhibitory effects of PKA on CIITA-driven class II MHC transcription. This is the first demonstration that the posttranslational modification of CIITA mediates inhibition of class II MHC transcription.
The one-loop effective potential of the Wess-Zumino model revisited
Creators: name: Kuzenko, Sergei M
name: Tyler, Simon J
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The full one-loop supersymmetric effective potential for the Wess-Zumino model is calculated using superfield techniques. This includes the Kähler potential and the auxiliary field potential, of which the former was originally computed in 1993 while the latter is derived for the first time. In the purely bosonic sector our results match those of older component field calculations. In light of prior contradictory results found in the literature, the calculation of the leading term in the auxiliary field potential is approached in a variety of ways. Issues related to conditional convergence that occur during these calculations and their possible consequences are discussed.
description: 32 pages
CI and CO in Nearby Spiral Galaxies -- I. Line Ratio and Abundance Variations at ~ 200 pc Scales
Creators: name: Liu, Daizhong
name: Schinnerer, Eva
name: Saito, Toshiki
name: Rosolowsky, Erik
name: Leroy, Adam
name: Usero, Antonio
name: Sandstrom, Karin
name: Klessen, Ralf S.
name: Glover, Simon C. O.
name: Ao, Yiping
name: Bešlić, Ivana
name: Bigiel, Frank
name: Cao, Yixian
name: Chastenet, Jérémy
name: Chevance, Mélanie
name: Dale, Daniel A.
name: Gao, Yu
name: Hughes, Annie
name: Kreckel, Kathryn
name: Kruijssen, J. M. Diederik
name: Pan, Hsi-An
name: Pety, Jérôme
name: Salak, Dragan
name: Santoro, Francesco
name: Schruba, Andreas
name: Sun, Jiayi
name: Teng, Yu-Hsuan
name: Williams, Thomas
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present new neutral atomic carbon [CI](3P1-3P0) mapping observations within the inner ~7 kpc and ~4 kpc of the disks of NGC3627 and NGC4321 at a spatial resolution of 190 pc and 270 pc, respectively, using the ALMA Atacama Compact Array (ACA). We combine these with the CO(2-1) data from PHANGS-ALMA, and literature [CI] and CO data for two other starburst and/or active galactic nucleus (AGN) galaxies (NGC1808, NGC7469), to study: a) the spatial distributions of CI and CO emission; b) the observed line ratio RCICO = I_[CI](1-0)/I_CO(2-1) as a function of various galactic properties; and c) the abundance ratio of [CI/CO]. We find excellent spatial correspondence between CI and CO emission and nearly uniform RCICO ~0.1 across the majority of the star-forming disks of NGC3627 and NGC4321. However, RCICO strongly varies from ~0.05 at the centre of NGC4321 to >0.2-0.5 in NGC1808's starburst centre and NGC7469's centre with an X-ray AGN. Meanwhile, RCICO does not obviously vary with $U$, similar to the prediction of PDR models. We also find a mildly decreasing RCICO with an increasing metallicity over 0.7-0.85 solar metallicity, consistent with the literature. Assuming various typical ISM conditions representing GMCs, active star-forming regions and strong starbursting environments, we calculate the LTE radiative transfer and estimate the [CI/CO] abundance ratio to be ~0.1 across the disks of NGC3627 and NGC4321, similar to previous large-scale findings in Galactic studies. However, this abundance ratio likely has a substantial increase to ~1 and >1-5 in NGC1808's starburst and NGC7469's strong AGN environments, respectively, in line with the expectations for cosmic-ray dominated region (CRDR) and X-ray dominated region (XDR) chemistry. Finally, we do not find a robust evidence for a generally CO-dark, CI-bright gas in the disk areas we probed. (abbreviated)
description: 23 pages, 13 figures and one table in total (17 pages and 9 figures in main text). Accepted for publication in A&A. For associated data cubes and moment maps, see https://www.canfar.net/storage/vault/list/phangs/RELEASES/DZLIU_etal_2022
title: Mamans et bébés, le droit à la santé
title: aimer, soigner et protéger
titleType: Subtitle
Creators: name: Aymon, Audrey
name: El Shwekh, Noura
Publisher: name: Unknown
Year: 0
Subjects: subject: SIDA
subject: VIH
subject: prévention
subject: relation mère-enfant
subject: femme
subject: grossesse
subject: nourrisson

description: La problématique de ce travail concerne la prévention de la transmission du VIH de la mère à son enfant qui demeure un défi dans des contextes où les ressources sont limitées. L'objectif est d'identifier quelles sont les stratégies infirmières qui peuvent être mises en place afin d’éviter la transmission VIH mère-enfant.
description: Mémoire de bachelor : Haute école de la santé La Source, 2014
HER4 Mediates Ligand-Dependent Antiproliferative and Differentiation Responses in Human Breast Cancer Cells
Creators: name: Harrelson, J.
name: Guttridge, K.
name: Sartor, C. I.
name: Ethier, S.
name: Caskey, L.
name: Kawata, E.
name: Hynes, N.
name: Kozlowska, E.
name: Zhou, H.
name: Calvo, B.
name: Earp, H. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: The function of the epidermal growth factor receptor (EGFR) family member HER4 remains unclear because its activating ligand, heregulin, results in either proliferation or differentiation. This variable response may stem from the range of signals generated by HER4 homodimers versus heterodimeric complexes with other EGFR family members. The ratio of homo- and heterodimeric complexes may be influenced both by a cell's EGFR family member expression profile and by the ligand or even ligand isoform used. To define the role of HER4 in mediating antiproliferative and differentiation responses, human breast cancer cell lines were screened for responses to heregulin. Only cells that expressed HER4 exhibited heregulin-dependent antiproliferative responses. In-depth studies of one line, SUM44, demonstrated that the antiproliferative and differentiation responses correlated with HER4 activation and were abolished by stable expression of a kinase-inactive HER4. HB-EGF, a HER4-specific ligand in this EGFR-negative cell line, also induced an antiproliferative response. Moreover, introduction and stable expression of HER4 in HER4-negative SUM102 cells resulted in the acquisition of a heregulin-dependent antiproliferative response, associated with increases in markers of differentiation. The role of HER2 in these heregulin-dependent responses was examined through elimination of cell surface HER2 signaling by stable expression of a single-chain anti-HER2 antibody that sequestered HER2 in the endoplasmic reticulum. In the cell lines with either endogenously (SUM44) or exogenously (SUM102) expressed HER4, elimination of HER2 did not alter HER4-dependent decreases in cell growth. These results suggest that HER4 is both necessary and sufficient to trigger an antiproliferative response in human breast cancer cells.
Prévenir l'hépatite C urgent d'agir
Creators: name: Althaus, Floriane
name: Briachetti, Célia
Publisher: name: Unknown
Year: 0
Subjects: subject: hépatite C
subject: santé publique
subject: traitement
subject: prévention

description: L’hépatite C est un problème de santé publique majeur chez les usagers de drogues. Le meilleur moyen de la prévenir est de mettre en place des stratégies de prévention adaptées. Cette population souvent en marge de la société est difficile d’accès c’est pourquoi il existe des structures présentant de faibles exigences qui leur permettent l’accès aux soins, aux traitements et à la prévention. Cette revue de littérature cherche à détailler le rôle infirmier dans la prévention primaire de l’hépatite C auprès des usagers de drogues fréquentant des structures bas seuil.
description: Mémoire de bachelor : Haute école de la santé La Source, 2014
Impurity-induced excitations in a topological two-dimensional ferromagnet/superconductor van der Waals moiré heterostructure
Creators: name: Khosravian, Maryam
name: Lado, Jose L.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The emergence of a topological superconducting state in van der Waals heterostructures provides a new platform for exploring novel strategies to control topological superconductors. In particular, impurities in van der Waals heterostructures, generically featuring a moire pattern, can potentially lead to the unique interplay between atomic and moire length scales, a feature absent in generic topological superconductors. Here we address the impact of non-magnetic impurities on a topological moire superconductor, both in the weak and strong regime, considering both periodic arrays and single impurities in otherwise pristine infinite moire systems. We demonstrate a fine interplay between impurity-induced modes and the moire length, leading to radically different spectral and topological properties depending on the relative impurity location and moire lengths. Our results highlight the key role of impurities in van der Waals heterostructures featuring moire patterns, revealing the key interplay between length and energy scales in artificial moire systems.
description: 14 pages, 7 figures
title: Je Gère!!
title: Signé Les Adolescents
titleType: Subtitle
Creators: name: Almeida, Yammise
Publisher: name: Unknown
Year: 0
Subjects: subject: adolescent
subject: maladie chronique
subject: vie quotidienne
subject: autosoin
subject: éducation du patient

description: Le but de cette revue de littérature est d’investiguer sur les représentations d’adolescents vivant avec une maladie chronique. Ceci afin de pouvoir proposer des interventions favorisant l’autosoin chez cette population atteinte de maladie chronique. La question clinique de recherche est la suivante : Dans un contexte de chronicité, quelles sont les stratégies infirmières favorisant le processus d’autosoin chez l’adolescent (13-15 ans) dans un service ambulatoire selon Dorotea Orem? L’adolescence est une période critique englobant de nombreux changements. Les transformations sont conséquentes et touchent divers domaines, tels que le social, le contexte familial, la sexualité, l’apparence physique ainsi que les fonctions cognitives. Une maladie chronique qui s’ajoute à cette période de vie, où l’on quitte l’enfance pour rejoindre le monde adulte, est un combat supplémentaire que doivent assumer ces jeunes. L’acquisition de l’autosoin est un élément essentiel au bien-être psychosocial et physique de cette population. Autant dans leur vie quotidienne que lors de la transition des soins pédiatriques aux soins adultes. C’est donc à partir de là, que je me suis questionnée sur la plus-value de l’intégration du modèle de Dorotea Orem sur l’autosoin.
description: Mémoire de bachelor : Haute école de la santé La Source, 2014
(:unas) unassigned
Creators: name: (:Unkn) Unknown
Publisher: name: Universita' degli Studi di Salerno
Year: 2024

description: È il 1998 quando Edoardo Sanguineti entra a far parte dell’OpLePo, l’opificio di letteratura potenziale nato sulla scorta del francese Ouvroir de Littérature Potentielle, fondato da Raymond Queneau in occasione di «une décade en septembre 1960 au château de Cerisy-la-Salle, intitulée Une nouvelle défense et illustration de la langue française». Tuttavia, risale a molti anni prima l’interessamento del poeta genovese nei confronti del gioco e delle sue contaminazioni con la letteratura, ed è proprio a partire da questo assunto che il presente intervento si propone di indagare la relazione che intercorre tra l’autore de Il Giuoco dell’oca e la ludicità, avvalendosi della testimonianza di alcuni documenti inediti (articoli di giornale, ritagli di riviste) conservati nelle teche della Sanguineti’s Wunderkammer e focalizzando l’attenzione sull’esperienza oplepiana e sul suo naturale legame con l’OuLiPo, tassello essenziale anche per la ricostruzione del rapporto dell’intellettuale italiano con la cultura d’Oltralpe.
Ejection of globular cluster interstellar media through ionization by white dwarfs
Creators: name: McDonald, Iain
name: Zijlstra, Albert
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: UV radiation from white dwarfs can efficiently clear Galactic globular clusters (GCs) of their intra-cluster medium (ICM). This solves the problem of the missing ICM in clusters, which is otherwise expected to build up to easily observable quantities. To show this, we recreate the ionizing flux in 47 Tuc, following randomly generated stars through their AGB, post-AGB and white dwarf evolution. Each white dwarf can ionize all the material injected into the cluster by stellar winds for ~3 Myr of its evolution: ~40 such white dwarfs exist at any point. Every GC's ICM should be ionized. The neutral cloud in M15 should be caused by a temporary overdensity. A pressure-supported ICM will expand over the cluster's tidal radius, where it will be truncated, allowing Jeans escape. The modelled Jeans mass-loss rate approximates the total stellar mass-loss rate, allowing efficient clearing of ICM. Any cluster's ICM mass should equal the mass injected by its stars over the sound-travel time between the cluster core and tidal radius. We predict ~11.3 solar masses of ICM within 47 Tuc, cleared over ~4 Myr, compared to a dynamical timescale of 4.3 Myr. We present a new mass hierarchy, discussing the transition between globular clusters dwarf galaxies.
description: 18 pages, 10 figures, accepted MNRAS
Isolation and Characterization of Point Mutations in Mismatch Repair Genes That Destabilize Microsatellites in Yeast
Creators: name: Petes, T. D.
name: Sia, E. A.
name: Dominska, M.
name: Stefanovic, L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: The stability of simple repetitive DNA sequences (microsatellites) is a sensitive indicator of the ability of a cell to repair DNA mismatches. In a genetic screen for yeast mutants with elevated microsatellite instability, we identified strains containing point mutations in the yeast mismatch repair genes, MSH2, MSH3, MLH1, and PMS1. Some of these mutations conferred phenotypes significantly different from those of null mutations in these genes. One semidominant MSH2 mutation was identified. Finally we showed that strains heterozygous for null mutations of mismatch repair genes in diploid strains in yeast confer subtle defects in the repair of small DNA loops.
title: L'effet d'un cours de formation sur la reconnaissance d'un état confusionnel aigu
title: une étude exploratoire chez les étudiants en soins infirmiers
titleType: Subtitle
Creators: name: Cornut, Sonam
name: Meyer, Rebecca
Publisher: name: Unknown
Year: 0
Subjects: subject: état confusionnel aigu
subject: delirium
subject: santé mentale
subject: trouble cognitif aigu
subject: personne âgée
subject: compétence infirmière

description: L’état confusionnel aigu (ECA), plus connu sous le nom de delirium dans les pays anglophones, est le trouble cognitif aigu le plus important chez la personne âgée. La nondétection et donc la non-prise en charge d’ECA peut avoir de graves conséquences sur l’état mental, physique et sur la survie de la personne âgée. D’importantes limites de connaissances chez les infirmiers ont été relevées quant à la détection et la capacité de faire la distinction entre un ECA et d’autres troubles psychiatriques de la personne âgée (dépression, troubles cognitifs de type de démence). La non-détection d’un ECA entraîne non seulement des conséquences chez le patient âgé, mais a également un impact sur la qualité des soins, la charge de travail et le coût de la santé.
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2013
Small parameters in infrared QCD: The pion decay constant
Creators: name: Peláez, Marcela
name: Reinosa, Urko
name: Serreau, Julien
name: Wschebor, Nicolás
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We continue our investigation of the QCD dynamics in terms of the Curci-Ferrari effective Lagrangian, a deformation of the Faddeev-Popov one in the Landau gauge with a tree-level gluon mass term. In a previous work we have studied the dynamics of chiral symmetry breaking at the level of the quark propagator and, in particular, the dynamical generation of a constituent quark mass. In the present article, we study the associated Goldstone mode, the pion, and we compute the pion decay constant in the chiral limit. Our approach exploits the fact that the coupling (defined in the Taylor scheme) in the pure gauge sector is perturbative, as observed in lattice simulations which, together with a $1/N_c$-expansion, allows for a systematic, controllable approximation scheme in the low energy regime of QCD. At leading order, this leads to the well-known rainbow-ladder resummation. We study the region of parameter space of the model that gives physical values of the pion decay constant. This allows one to constrain the gluon mass parameter as a function of the coupling using a physically measured quantity.
description: 21 pages, 11 figures
Mutations in the RNA Binding Domain of Stem-Loop Binding Protein Define Separable Requirements for RNA Binding and for Histone Pre-mRNA Processing
Creators: name: Greenland, J. A.
name: Dominski, Z.
name: Marzluff, W. F.
name: Erkmann, J. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Expression of replication-dependent histone genes at the posttranscriptional level is controlled by stem-loop binding protein (SLBP). One function of SLBP is to bind the stem-loop structure in the 3′ untranslated region of histone pre-mRNAs and facilitate 3′ end processing. Interaction of SLBP with the stem-loop is mediated by the centrally located RNA binding domain (RBD). Here we identify several highly conserved amino acids in the RBD mutation of which results in complete or substantial loss of SLBP binding activity. We also identify residues in the RBD which do not contribute to binding to the stem-loop RNA but instead are required for efficient recruitment of U7 snRNP to histone pre-mRNA. Recruitment of the U7 snRNP to the pre-mRNA also depends on the 20-amino-acid region located immediately downstream of the RBD. A critical region of the RBD contains the sequence YDRY. The tyrosines are required for RNA binding, and the DR dipeptide is essential for processing but not for RNA binding. It is likely that the RBD of SLBP interacts directly with both the stem-loop RNA and other processing factor(s), most likely the U7 snRNP, to facilitate histone pre-mRNA processing.
title: La compétence culturelle
title: un défi pour les infirmières et infirmiers de demain
titleType: Subtitle
Creators: name: Strehler, Pauline
name: Ursenbacher, Muaziza
Publisher: name: Unknown
Year: 0
Subjects: subject: formation infirmière
subject: qualité des soins
subject: compétences professionnelles
subject: interculturalité

description: Cette revue de littérature cherche à expliquer la relation entre les compétences culturelles acquises lors de la formation initiale ou continue en soins infirmiers et leurs impacts sur la qualité des soins ceci dans un contexte culturel en permanente évolution. Nous avons choisi la question de recherche suivante : « Quelles influences ont les compétences culturelles acquises par le biais de la formation initiale ou continue en soins infirmer sur la qualité des soins pour tout bénéficiaire? ».
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2013