cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
(502459) Morison Cumming
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A Physiologically Based Pharmacokinetic Framework for Quantifying Antibody Distribution Gradients from Tumors to Tumor-Draining Lymph Nodes
Creators: name: Cao, Yanguang
name: Salgado, Eric
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Immune checkpoint blockades prescribed in the neoadjuvant setting are now under active investigation for many types of tumors, and many have shown early success. The primary tumor (PT) and tumor-draining lymph node (TDLN) immune factors, along with adequate therapeutic antibody distributions to the PT and TDLN, are critical for optimal immune activation and anti-tumor efficacy in neoadjuvant immunotherapy. However, it remains largely unknown how much of the antibody can be distributed into the PT-TDLN axis at different clinical scenarios. The goal of the current work is to build a physiologically based pharmacokinetic (PBPK) model framework capable of characterizing antibody distribution gradients in the PT-TDLN axis across various clinical and pathophysiological scenarios. The model was calibrated using clinical data from immuno-PET antibody-imaging studies quantifying antibody pharmacokinetics (PK) in the blood, PTs, and TDLNs. The effects of metastatic lesion location, tumor-induced compression, and inflammation, as well as surgery, on antibody concentration gradients in the PT-TDLN axis were characterized. The PBPK model serves as a valuable tool to predict antibody exposures in various types of tumors, metastases, and the associated lymph node, supporting effective immunotherapy.
Dispersion of particles by a strong explosion
Creators: name: DuBois, Timothy C.
name: Jamriska, Milan
name: Skvortsov, Alex
Publisher: name: arXiv
Year: 2015
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The dynamics of particle transport under the influence of localised high energy anomalies (explosions) is a complicated phenomena dependent on many physical parameters of both the particle and the medium it resides in. Here we present a conceptual model that establishes simple scaling laws for particle dispersion in relation to the energy released in a blast, properties of the medium, physical properties of particles and their initial position away from a blast epicenter. These dependencies are validated against numerical simulations and we discuss predictions of the model which can be validated experimentally. Other applications and extensions to the framework are also considered.
description: 8 pages, 4 figures, 1 table
24.77 Pflops on a Gravitational Tree-Code to Simulate the Milky Way Galaxy with 18600 GPUs
Creators: name: Bédorf, Jeroen
name: Gaburov, Evghenii
name: Fujii, Michiko S.
name: Nitadori, Keigo
name: Ishiyama, Tomoaki
name: Zwart, Simon Portegies
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: We have simulated, for the first time, the long term evolution of the Milky Way Galaxy using 51 billion particles on the Swiss Piz Daint supercomputer with our $N$-body gravitational tree-code Bonsai. Herein, we describe the scientific motivation and numerical algorithms. The Milky Way model was simulated for 6 billion years, during which the bar structure and spiral arms were fully formed. This improves upon previous simulations by using 1000 times more particles, and provides a wealth of new data that can be directly compared with observations. We also report the scalability on both the Swiss Piz Daint and the US ORNL Titan. On Piz Daint the parallel efficiency of Bonsai was above 95%. The highest performance was achieved with a 242 billion particle Milky Way model using 18600 GPUs on Titan, thereby reaching a sustained GPU and application performance of 33.49 Pflops and 24.77 Pflops respectively.
description: 12 pages, 4 figures, Published in: 'Proceeding SC '14 Proceedings of the International Conference for High Performance Computing, Networking, Storage and Analysis'. Gordon Bell Prize 2014 finalist
Gamma-ray emission from young supernova remnants: hadronic or leptonic?
Creators: name: Gabici, S.
name: Aharonian, F. A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The debate on the nature of the gamma-ray emission from young supernova remnants is still open. Ascribing such emission to hadronic rather than leptonic processes would provide an evidence for the acceleration of protons and nuclei, and this fact would fit with the very popular (but not proven) paradigm that supernova remnants are the sources of Galactic cosmic rays. Here, we discuss this issue with a particular focus on the best studied gamma-ray-bright supernova remnant: RX~J1713.7-3946.
description: invited talk at RICAP 2014
SUV VA GIDROSFERANING KELIB CHIQISH OMILLARI
Creators: name: Nurmatova, Ruxsora
Publisher: name: Zenodo
Year: 2023

description: Yerda suvning kelib chiqishi haqida oltita faraz mavjud. Birinchi gipoteza Yerning "issiq" kelib chiqishidan kelib chiqadi. Taxminlarga ko'ra, Yer bir vaqtlar erigan olov shari bo'lib, asta-sekin soviydi va kosmosga issiqlik tarqaladi. Birinchi qobiq paydo bo'ldi, elementlarning kimyoviy birikmalari paydo bo'ldi va ular orasida vodorod va kislorod birikmasi, yoki oddiyroq, suv bor edi.
Identification and mechanical control of ferroelastic domain structure in rhombohedral CaMn$_7$O$_{12}$
Creators: name: Yuan, Renliang
name: Duan, Lian
name: Du, Xinyu
name: Li, Yuan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We report on observation of ferroelastic domain structure in single crystals of multiferroic CaMn$_7$O$_{12}$ at room temperature. Two types of ferroelastic domain wall are found, consistent with the material's rhombohedral symmetry that is reduced from cubic symmetry at higher temperatures. Using Raman spectroscopy along with other measurements, we develop a systematic method to determine the microscopic domain orientation. Moreover, we find a switching behavior of the domains, which allows us to detwin the crystals conveniently at room temperature using a moderate uniaxial compression. Our result paves the way for further spectroscopic study and domain engineering in CaMn$_7$O$_{12}$.
description: 7 pages, 4 figures
Supplementary Material from Water limitation drives species loss in grassland communities after nitrogen addition and warming
Creators: name: Li, Hailing
name: Chen, Juan
name: Penuelas, Josep
name: Sardans, Jordi
name: Collins, Scott L.
name: Yu, Kailiang
name: Song, Chao
name: Ye, Jian-Sheng
Publisher: name: The Royal Society
Year: 2024
Subjects: classificationCode: 310399
subject: Ecology not elsewhere classified

description: Yejsh_tables_figures_ESM.docx
(502491) George Lovell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(502440) Edward May
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(502447) ___ ? Paterson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(502438) Elizabeth [Shuckburgh]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Integrating IPAT and CLUMondo Models to Assess the Impact of Carbon Peak on Land Use
Creators: name: Tian, Fuan
name: Wu, Jianxian
name: Wang, Han
name: Nie, Xin
name: Jin, Yujie
name: Hong, Xingming
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: China’s growth plans include a carbon emission peak policy, which is a restriction that indirectly impacts land use structure. In this study, we simulate different paths for achieving policy objectives, and explore the linkages between those paths and land use change. The IPAT model was used to simulate the carbon emissions generated from a natural development scenario, an ideal policy scenario, and a retributive carbon emission scenario in China from 2020 to 2030. The simulation results were incorporated into the CLUMondo model as a demand driver to simulate the land use change in 2030. The results show that carbon emission peak policy can somewhat reduce carbon emissions and increase building land in a regulated way. However, the policy may also lead to a short-term surge in carbon emissions, a reactive expansion of arable land and building land. This may reduce losses in economic development when carbon emissions are limited, but does not achieve the integration of social, economic, and ecological goals. This study links the carbon emission peak policy with land use change and provides a fresh perspective on the Chinese government’s carbon reduction policy.
(502439) Gundreda Shuckburgh
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A Leucyl-tRNA Synthetase Urzyme: Authenticity of tRNA Synthetase Catalytic Activities and Promiscuous Phosphorylation of Leucyl-5′AMP
Creators: name: Hobson, Jessica J.
name: Hu, Hao
name: Carter, Charles W.
name: Li, Zhijie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Aminoacyl-tRNA synthetase (aaRS)/tRNA cognate pairs translate the genetic code by synthesizing specific aminoacyl-tRNAs that are assembled on messenger RNA by the ribosome. Deconstruction of the two distinct aaRS superfamilies (Classes) has provided conceptual and experimental models for their early evolution. Urzymes, containing ~120–130 amino acids excerpted from regions where genetic coding sequence complementarities have been identified, are key experimental models motivated by the proposal of a single bidirectional ancestral gene. Previous reports that Class I and Class II urzymes accelerate both amino acid activation and tRNA aminoacylation have not been extended to other synthetases. We describe a third urzyme (LeuAC) prepared from the Class IA Pyrococcus horikoshii leucyl-tRNA synthetase. We adduce multiple lines of evidence for the authenticity of its catalysis of both canonical reactions, amino acid activation and tRNALeu aminoacylation. Mutation of the three active-site lysine residues to alanine causes significant, but modest reduction in both amino acid activation and aminoacylation. LeuAC also catalyzes production of ADP, a non-canonical enzymatic function that has been overlooked since it first was described for several full-length aaRS in the 1970s. Structural data suggest that the LeuAC active site accommodates two ATP conformations that are prominent in water but rarely seen bound to proteins, accounting for successive, in situ phosphorylation of the bound leucyl-5′AMP phosphate, accounting for ADP production. This unusual ATP consumption regenerates the transition state for amino acid activation and suggests, in turn, that in the absence of the editing and anticodon-binding domains, LeuAC releases leu-5′AMP unusually slowly, relative to the two phosphorylation reactions.
Art and Land: Eucalyptus Plantations in Brazilian Documentaries
Creators: name: Gesteira, Santiago G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: In Brazil, since the early 2000s, different documentaries have raised awareness about the problematic issues that tree plantations, especially eucalyptus, provoke, as they are propagated across the country. By means of interviews and a mix of investigative and expository styles, these films address and denounce the controversial role and power of the timber industry. However, in the last few years, other works have approached the relationships between planted forests and local ecosystems, offering an alternative perspective. This essay analyzes two recent films on the issue, the short film Gerais, and the 78 min long Do pó da terra, released in 2015 and 2016, respectively, while looking at another short documentary, Desertos verdes: plantações de eucaliptos, agrotóxicos e água, released in 2017, a straightforward documentary that advocates against eucalyptus plantations, interviews specialists and activists, and shows data that work as a report about the situation. In Gerais and Do pó da terra, forest plantations are not central narratives, rather, the focus is on specific communities and their customs. Through testimonial, observational, and poetic modes, they discuss the challenges faced by local inhabitants as their unique lifestyles and sociocultural expressions are threatened. Thus, this essay explains how, instead of images of destruction and the specificities of eucalyptus environmental effects, these documentaries choose to show the connection of local people and their art with the land, their daily life, and the changes they face. By crucially emphasizing the different timelines in play, that of western modernity, and that of alternative understandings of life–nature, they differ from other approaches towards filming environmental conflict that stress the immediacy of the situation. These two films offer a more intimate perspective of human beings, in interplay with their ecosystem, which allows for reflection on how they cohabitate and look forward.
(502359) Thomas william Crowther
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(502423) Thomas Howard
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Enhancer RNA Transcription Is Essential for a Novel CSF1 Enhancer in Triple-Negative Breast Cancer
Creators: name: Franco, Hector L.
name: Regner, Matthew J.
name: Li, Shen
name: Coffey, Alisha
name: Kelly, Michael R.
name: Wisniewska, Kamila
name: Lewis, Michael W.
name: King, Caitlin M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Enhancers are critical regulatory elements in the genome that help orchestrate spatiotemporal patterns of gene expression during development and normal physiology. In cancer, enhancers are often rewired by various genetic and epigenetic mechanisms for the activation of oncogenes that lead to initiation and progression. A key feature of active enhancers is the production of non-coding RNA molecules called enhancer RNAs, whose functions remain unknown but can be used to specify active enhancers de novo. Using a combination of eRNA transcription and chromatin modifications, we have identified a novel enhancer located 30 kb upstream of Colony Stimulating Factor 1 (CSF1). Notably, CSF1 is implicated in the progression of breast cancer, is overexpressed in triple-negative breast cancer (TNBC) cell lines, and its enhancer is primarily active in TNBC patient tumors. Genomic deletion of the enhancer (via CRISPR/Cas9) enabled us to validate this regulatory element as a bona fide enhancer of CSF1 and subsequent cell-based assays revealed profound effects on cancer cell proliferation, colony formation, and migration. Epigenetic silencing of the enhancer via CRISPR-interference assays (dCas9-KRAB) coupled to RNA-sequencing, enabled unbiased identification of additional target genes, such as RSAD2, that are predictive of clinical outcome. Additionally, we repurposed the RNA-guided RNA-targeting CRISPR-Cas13 machinery to specifically degrade the eRNAs transcripts produced at this enhancer to determine the consequences on CSF1 mRNA expression, suggesting a post-transcriptional role for these non-coding transcripts. Finally, we test our eRNA-dependent model of CSF1 enhancer function and demonstrate that our results are extensible to other forms of cancer. Collectively, this work describes a novel enhancer that is active in the TNBC subtype, which is associated with cellular growth, and requires eRNA transcripts for proper enhancer function. These results demonstrate the significant impact of enhancers in cancer biology and highlight their potential as tractable targets for therapeutic intervention.
Extremity Exercise Program in Breast Cancer Survivors Suffering from Chemotherapy-Induced Peripheral Neuropathy: A Feasibility Pilot Study
Creators: name: Chen, Yun-Hen
name: Yen, Li-Yu
name: Chan, Ya-Ning
name: Wu, Chih-Jung
name: Wang, Ya-Jung
name: Lo, Chyi
name: Tseng, Ling-Ming
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Objectives: To evaluate the feasibility of implementation of an extremity exercise program and to examine its preliminary effects in breast cancer survivors suffering from chemotherapy-induced peripheral neuropathy (CIPN). Sample & Setting: Thirteen breast cancer survivors from one hospital in northern Taiwan. Methods and Variables: A single group with repeated measures, and a quasi-experimental design. The intervention program was a four week, home-based extremity exercise program that was comprised of 10 skilled hand exercises and Buerger-Allen exercises. The Total Neuropathy Scale (clinical version), Functional Assessment of Cancer Therapy/Gynecologic Oncology Group, Neurotoxicity (13-Item Version), Identification Pain Questionnaire, and pain Visual Analogue Scale were used to measure CIPN before exercise (T1), during (T2~T4), and after exercise (T5). Qualitative data were also collected at each time point. Data were analyzed by using descriptive statistics, generalized estimating equations, and directed content analysis. Results: None of the participants reported adverse events during the study period. The extremity exercise program significantly improved patient-reported CIPN after intervention at T4 or T5 but was insignificant on clinician-assessed CIPN. The qualitative data of participant experience indicated that this program is feasible and easy to follow. Conclusion: The extremity exercise program is feasible but needs to increase the sample size and prolong the intervention period for confirmation.
Not all bad: Gyromitrin has a limited distribution in the false morels as determined by a new ultra high-performance liquid chromatography method
Creators: name: Dirks, Alden C.
name: Mohamed, Osama G.
name: Schultz, Pamela J.
name: Miller, Andrew N.
name: Tripathi, Ashootosh
name: James, Timothy Y.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Gyromitrin (acetaldehyde N-methyl-N-formylhydrazone) and its homologs are deadly mycotoxins produced most infamously by the lorchel (also known as false morel) Gyromitra esculenta, which is paradoxically consumed as a delicacy in some parts of the world. There is much speculation about the presence of gyromitrin in other species of the lorchel family (Discinaceae), but no studies have broadly assessed its distribution. Given the history of poisonings associated with the consumption of G. esculenta and G. ambigua, we hypothesized that gyromitrin evolved in the last common ancestor of these taxa and would be present in their descendants with adaptive loss of function in the nested truffle clade, Hydnotrya. To test this hypothesis, we developed a sensitive analytical derivatization method for the detection of gyromitrin using 2,4-dinitrobenzaldehyde as the derivatization reagent. In total, we analyzed 66 specimens for the presence of gyromitrin over 105 tests. Moreover, we sequenced the nuc rDNA internal transcribed spacer region ITS1-5.8S-ITS2 (ITS barcode) and nuc 28S rDNA to assist in species identification and to infer a supporting phylogenetic tree. We detected gyromitrin in all tested specimens from the G. esculenta group as well as G. leucoxantha. This distribution is consistent with a model of rapid evolution coupled with horizontal transfer, which is typical for secondary metabolites. We clarified that gyromitrin production in Discinaceae is both discontinuous and more limited than previously thought. Further research is required to elucidate the gyromitrin biosynthesis gene cluster and its evolutionary history in lorchels.
Exploring a New Theoretical Model to Explain the Behavior of Medication Adherence
Creators: name: Unni, Elizabeth
name: Bae, Sun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Medication adherence is essential for optimal therapeutic outcomes. However, non-adherence with long-term therapy is at 50%. Several theoretical models have identified several key factors that could explain medication adherence. Though numerous interventions have been developed based on these theoretical models, the success rates with interventions are not the best. This paper proposes a new Hierarchical Model for Medication Adherence. In this model, we propose medication adherence as a five-tier model with medication adherence as the desirable behavior on the top of the pyramid. From the bottom of the hierarchy upwards, the skills/beliefs/behaviors to be achieved are: health literacy, belief in illness (impacted by perceived susceptibility and severity of illness), belief in medicines (impacted by treatment satisfaction), and self-efficacy (impacted by social support). The model further proposes that each individual will achieve or already have these skills/beliefs/behaviors at various levels. Screening patients for these benchmarks will enable providers to decide where to target interventions.
A genome-wide screen for variants influencing certolizumab pegol response in a moderate to severe rheumatoid arthritis population
Creators: name: Praet, C.
name: Urban, T.J.
name: Chamberlain, C.
name: McHale, D.
name: Shea, P.R.
name: White, I.R.
name: Maia, J.M.
name: Xie, P.
name: Kleinstein, S.E.
name: Goldstein, D.B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Certolizumab pegol (CZP) is a PEGylated Fc-free tumor necrosis factor (TNF) inhibitor antibody approved for use in the treatment of rheumatoid arthritis (RA), Crohn's disease, psoriatic arthritis, axial spondyloarthritis and psoriasis. In a clinical trial of patients with severe RA, CZP improved disease symptoms in approximately half of patients. However, variability in CZP efficacy remains a problem for clinicians, thus, the aim of this study was to identify genetic variants predictive of CZP response. We performed a genome-wide association study (GWAS) of 302 RA patients treated with CZP in the REALISTIC trial to identify common single nucleotide polymorphisms (SNPs) associated with treatment response. Wholeexome sequencing was also performed for 74 CZP extreme responders and non-responders within the same population, as well as 1546 population controls. No common SNPs or rare functional variants were significantly associated with CZP response, though a non-significant enrichment in the RA-implicated KCNK5 gene was observed. Two SNPs near spondin- 1 and semaphorin-4G approached genome-wide significance. The results of the current study did not provide an unambiguous predictor of CZP response.
การสลับรหัสในวาทกรรมของผู้สอนชาวไทยภายในชั้นเรียนกลุ่มวิชาบังคับร่วม คณะศิลปศาสตร์ มหาวิทยาลัยรังสิต
Creators: name: Domalewska, Dorota
Publisher: name: ศูนย์สนับสนุนและพัฒนาการเรียนการสอน มหาวิทยาลัยรังสิต
Year: 2017
Subjects: classroom discourse
code switching
foreign language learning,
teacher talk
การพูดของอาจารย์
การสลับรหัสในวาทกรรม
การเรียนภาษาต่างประเทศ
วาทกรรมในชั้นเรียน

description: วารสารพัฒนาการเรียนการสอน, 11, 1, 95-109
การใช้การเรียนรู้แบบร่วมมือในวิชาการอ่านภาษาอังกฤษในฐานะภาษาต่างประเทศ: กรณีศึกษาของผลกระทบต่อนักศึกษาไทยในระดับอุดมศึกษา
Creators: name: Nipaporn Chalermnirundorn
Publisher: name: ศูนย์สนับสนุนและพัฒนาการเรียนการสอน มหาวิทยาลัยรังสิต
Year: 2017
Subjects: Collaborative Learning
EFL reading
Tertiary Level
การอ่านภาษาอังกฤษที่เป็นภาษาต่างประเทศ
ทฤษฎีการเรียนรู้แบบร่วมมือ
ระดับอุดมศึกษา

description: วารสารพัฒนาการเรียนการสอน, 11, 1, 110-122
Masking Adherence in K–12 Schools and SARS-CoV-2 Secondary Transmission
Creators: name: Weber, David J.
name: Boutzoukas, Angelique E.
name: Mann, Tara K.
name: Pendleton, Joanna
name: Brookhart, M. Alan
name: Jackman, Jennifer G.
name: Blakemore, Ashley
name: Panayotti, Gabriela M. Maradiaga
name: Garcés, Andrew Willis
name: Edwards, Laura
name: Corneli, Amy
name: Moorthy, Ganga S.
name: Zimmerman, Kanecia O.
name: Benjamin, Jr., Daniel K.
name: Warren, Todd
name: Kalu, Ibukunoluwa C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: OBJECTIVES: Masking is an essential coronavirus 2019 mitigation tool assisting in the safe return of kindergarten through 12th grade children and staff to in-person instruction; however, masking adherence, compliance evaluation methods, and potential consequences of surveillance are currently unknown. We describe two school districts' approaches to promote in-school masking and the consequent impact on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) secondary transmission.METHODS: Two North Carolina school districts developed surveillance programs with daily vs. weekly interventions to monitor in-school masking adherence. Safety teams recorded the proportion of students and staff appropriately wearing masks and provided real-time education after observation of improper masking. Primary infections, within-school transmission, and county-level SARS-CoV-2 infection rates were assessed.RESULTS: Proper mask use was high in both intervention groups and districts. There were variations by grade level, with lower rates in elementary schools, and proper adherence being higher in the weekly surveillance group. Rates of secondary transmission were low in both districts with surveillance programs, regardless of intervention frequency.CONCLUSIONS: Masking surveillance interventions are effective at ensuring appropriate masking at all school levels. Creating a culture of safety within schools led by local leadership is important and a feasible opportunity for school districts with return to in-person school. In our study of schools with high masking adherence, secondary transmission was low.
Coca : Immortal leaves, pressured farmers and U.S. foreign policy
Creators: name: Champagne, Sarah
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020
Subjects: Interviews
Interactive multimedia

description: The purpose of this project is to document a more distant reality: the farmers responsible for coca production. Taking a dive in their life is an opportunity to see the debate on the war on drugs through its human consequences. Whether in terms of security, health and environment, this project is a unique window into their world and their struggles, inviting them in the debate.
A New Area Law in General Relativity
Creators: name: Bousso, Raphael
name: Engelhardt, Netta
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We report a new area law in General Relativity. A future holographic screen is a hypersurface foliated by marginally trapped surfaces. We show that their area increases monotonically along the foliation. Future holographic screens can easily be found in collapsing stars and near a big crunch. Past holographic screens exist in any expanding universe and obey a similar theorem, yielding the first rigorous area law in big bang cosmology. Unlike event horizons, these objects can be identified at finite time and without reference to an asymptotic boundary. The Bousso bound is not used, but it naturally suggests a thermodynamic interpretation of our result.
description: 4 pages, 2 figures; v3: typos fixed
Performance characterization of a broadband vector Apodizing Phase Plate coronagraph
Creators: name: Otten, G. P. P. L.
name: Snik, F.
name: Kenworthy, M. A.
name: Miskiewicz, M. N.
name: Escuti, M. J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: One of the main challenges for the direct imaging of planets around nearby stars is the suppression of the diffracted halo from the primary star. Coronagraphs are angular filters that suppress this diffracted halo. The Apodizing Phase Plate coronagraph modifies the pupil-plane phase with an anti-symmetric pattern to suppress diffraction over a 180 degree region from 2 to 7 λ/D and achieves a mean raw contrast of 10^-4 in this area, independent of the tip-tilt stability of the system. Current APP coronagraphs implemented using classical phase techniques are limited in bandwidth and suppression region geometry (i.e. only on 1 side of the star). In this paper, we show the vector-APP (vAPP) whose phase pattern is implemented by the orientation of patterned liquid crystals. Beam-splitting according to circular polarization states produces two, complementary PSFs with dark holes on either side. We have developed a prototype vAPP that consists of a stack of 3 twisting liquid crystal layers with a bandwidth of 500-900 nm. We characterize the properties of this device using reconstructions of the pupil-plane pattern, and of the ensuing PSF structures. By imaging the pupil between crossed and parallel polarizers we reconstruct the fast axis pattern, transmission, and retardance of the vAPP, and use this as input for a PSF model. This model includes aberrations of the laboratory set-up, and matches the measured PSF, which shows a raw contrast of 10^-3.8 between 2 and 7 λ/D in a 135 degree wedge. The vAPP coronagraph is relatively easy to manufacture and can be implemented together with a broadband quarter-wave plate and Wollaston prism in a pupil wheel in high-contrast imaging instruments. The manufacturing techniques permit the application of phase patterns with deeper contrasts inside the dark holes and enables unprecedented spectral bandwidths for phase-manipulation coronagraphy.
description: 28 pages, 19 figures, 1 table
Constructing ab initio models of ultra-thin Al-AlOx-Al barriers
Creators: name: DuBois, Timothy C.
name: Cyster, Martin J.
name: Opletal, George
name: Russo, Salvy P.
name: Cole, Jared H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The microscopic structure of ultra-thin oxide barriers often plays a major role in modern nano-electronic devices. In the case of superconducting electronic circuits, their operation depends on the electrical non-linearity provided by one or more such oxide layers in the form of ultra-thin tunnel barriers (also known as Josephson junctions). Currently available fabrication techniques manufacture an amorphous oxide barrier, which is attributed as a major noise source within the device. The nature of this noise is currently an open question and requires both experimental and theoretical investigation. Here, we present a methodology for constructing atomic scale computational models of Josephson junctions using a combination of molecular mechanics, empirical and ab initio methods. These junctions consist of ultra-thin amorphous aluminium-oxide layers sandwiched between crystalline aluminium. The stability and structure of these barriers as a function of density and stoichiometry are investigated, which we compare to experimentally observed parameters
description: 7 pages, 4 figures, 1 table. For special issue dedicated to Prof. Ian Snook
Correlation-driven topological Fermi surface transition in FeSe
Creators: name: Leonov, I.
name: Skornyakov, S. L.
name: Anisimov, V. I.
name: Vollhardt, D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The electronic structure and phase stability of paramagnetic FeSe is computed by using a combination of ab initio methods for calculating band structure and dynamical mean-field theory. Our results reveal a topological change (Lifshitz transition) of the Fermi surface upon a moderate expansion of the lattice. The Lifshitz transition is accompanied with a sharp increase of the local moments and results in an entire reconstruction of magnetic correlations from the in-plane magnetic wave vector $(π,π)$ to $(π,0)$. We attribute this behavior to a correlation-induced shift of the Van Hove singularity originating from the $d_{xy}$ and $d_{xz}/d_{yz}$ bands at the M-point across the Fermi level. We propose that superconductivity is strongly influenced, or even induced, by a Van Hove singularity.
description: 5 pages, 4 figures
Comparison of adaptive multiple phenotype association tests using summary statistics in genome-wide association studies
Creators: name: Avery, C.L.
name: McKnight, B.
name: Hodonsky, C.J.
name: Baldassari, A.R.
name: Sitlani, C.M.
name: Highland, H.M.
Publisher: name: NLM (Medline)
Year: 2021

description: Genome-wide association studies have been successful mapping loci for individual phenotypes, but few studies have comprehensively interrogated evidence of shared genetic effects across multiple phenotypes simultaneously. Statistical methods have been proposed for analyzing multiple phenotypes using summary statistics, which enables studies of shared genetic effects while avoiding challenges associated with individual-level data sharing. Adaptive tests have been developed to maintain power against multiple alternative hypotheses because the most powerful single-alternative test depends on the underlying structure of the associations between the multiple phenotypes and a single nucleotide polymorphism (SNP). Here we compare the performance of six such adaptive tests: two adaptive sum of powered scores (aSPU) tests, the unified score association test (metaUSAT), the adaptive test in a mixed-models framework (mixAda) and two principal-component-based adaptive tests (PCAQ and PCO). Our simulations highlight practical challenges that arise when multivariate distributions of phenotypes do not satisfy assumptions of multivariate normality. Previous reports in this context focus on low minor allele count (MAC) and omit the aSPU test, which relies less than other methods on asymptotic and distributional assumptions. When these assumptions are not satisfied, particularly when MAC is low and/or phenotype covariance matrices are singular or nearly singular, aSPU better preserves type I error, sometimes at the cost of decreased power. We illustrate this trade-off with multiple phenotype analyses of six quantitative electrocardiogram traits in the Population Architecture using Genomics and Epidemiology (PAGE) study.
การเรียนการสอนภาษาอังกฤษผ่านเทคโนโลยีสารสนเทศและการสื่อสารในศตวรรษที่ 21
Creators: name: ศิตา เยี่ยมขันติถาวร
Publisher: name: ศูนย์สนับสนุนและพัฒนาการเรียนการสอน มหาวิทยาลัยรังสิต
Year: 2017
Subjects: 21 Century
English Instruction
Information and Communication Technologies
การเรียนการสอนภาษาอังกฤษ
ศตวรรษที่ 21
เทคโนโลยีสารสนเทศและการสื่อสาร

description: วารสารพัฒนาการเรียนการสอน, 11, 1, 123-134
(502429) [Mrs] ____ Matthews
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(502356) Fanny Harker
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
การจัดการเรียนการสอนที่ส่งเสริมความคิดสร้างสรรค์โดยใช้ศิลปะเป็นฐาน
Creators: name: อติยศ สรรคบุรานุรักษ์
Publisher: name: ศูนย์สนับสนุนและพัฒนาการเรียนการสอน มหาวิทยาลัยรังสิต
Year: 2017
Subjects: Arts Based Learning
Creativity
Instructional
การจัดการเรียนการสอน
ความคิดสร้างสรรค์
ศิลปะเป็นฐาน

description: วารสารพัฒนาการเรียนการสอน, 11, 1, 135-150
ผลกระทบของการจัดการเรียนรู้แบบสืบเสาะหาความรู้ (Inquiry-based learning) ที่มีผลต่อผลสัมฤทธิ์ทางการเรียนและความพึงพอใจ ในการเรียนรู้ของนักเรียนเกรด 4 ที่มีต่อวิชาวิทยาศาสตร์
Creators: name: Pema Yangden
Publisher: name: ศูนย์สนับสนุนและพัฒนาการเรียนการสอน มหาวิทยาลัยรังสิต
Year: 2017
Subjects: Inquiry-based learning approach
Learning Achievement
Learning Satisfaction
Science
การจัดการเรียนรู้แบบสืบเสาะหาความรู้
ความพึงพอใจในการเรียนรู้
ผลสัมฤทธิ์ทางการเรียน
วิชาวิทยาศาสตร์

description: วารสารพัฒนาการเรียนการสอน, 11, 2, 1-11
Cosmological simulations of galaxy formation with cosmic rays
Creators: name: Salem, Munier
name: Bryan, Greg L.
name: Hummels, Cameron
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We investigate the dynamical impact of cosmic rays in cosmological simulations of galaxy formation using adaptive-mesh refinement simulations of a $10^{12}$ solar mass halo. In agreement with previous work, a run with only our standard thermal energy feedback model results in a massive spheroid and unrealistically peaked rotation curves. However, the addition of a simple two-fluid model for cosmic rays drastically changes the morphology of the forming disk. We include an isotropic diffusive term and a source term tied to star formation due to (unresolved) supernova-driven shocks. Over a wide range of diffusion coefficients, the CRs generate thin, extended disks with a significantly more realistic (although still not flat) rotation curve. We find that the diffusion of CRs is key to this process, as they escape dense star forming clumps and drive outflows within the more diffuse ISM.
description: 5 pages, 4 figures, ApJL in press
Obesity Prediction Based on Logistic Regression, Random Forest and Support Vector Machine
Creators: name: Huang, Shuai
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Obesity is a risk factor for many diseases. The mechanisms of obesity are not well understood. There are also no effective sustainable obesity interventions. Hence, identifying important risk factors may lead to developing effective obesity prevention strategies and programs. In this paper, I used three classification models including logistic regression, random forest and support vector machine to fit prediction models to find the most important risk factors for obesity, and compared the performance of different models.
Magnetism and a field-cycling induced effect in staircase Kagomé antiferromagnet PbCu$_3$TeO$_7$ revealed by NMR
Creators: name: Dai, J.
name: Wang, P. S.
name: Sun, S. S.
name: Pang, F.
name: Zhang, J. S.
name: Dong, X. L.
name: Yue, G.
name: Jin, K.
name: Cong, J. Z.
name: Sun, Y.
name: Yu, Weiqiang
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We report $^{125}$Te and $^{63,65}$Cu nuclear magnetic resonance (NMR) studies on single crystals of staircase Kagomé antiferromagnet PbCu3TeO7 ($T_{N1}\approx$ 36 K). A Curie constant as large as $Θ$~140 K is obtained by a Curie-Weiss fitting of the high-temperature Knight shift. The frustration factor f (= $Θ/T_N $)$\approx$ 4 implies intermediate frustration in this system. From the high-temperature Knight shift data of $^{125}$Te, its hyperfine coupling constant is estimated to be $^{125}A_{hf}$ = -67 kOe/$μ_B$, which suggests a strong interlayer coupling bridging the neighboring Kagomé layers. At $T$= 2 K, we find two types of zero-field NMR signals. One has no dependence on the history of the field treatment, which is consistent with Cu NMR signals from inequivalent Cu sites with different internal hyperfine fields. The other one is only seen after a field-cycling process, which is consistent with domain wall contributions in this frustrated antiferromagnet.
description: Revised argument
การใช้รูปแบบกระบวนการแก้ปัญหาตามแนวคิดของโพลยา (Polya) เพื่อเพิ่มผลสัมฤทธิ์ ทางการเรียนของนักเรียนภูฎานเกรด 10 ในวิชาตรีโกณมิติ
Creators: name: Yeshey Choden
Publisher: name: ศูนย์สนับสนุนและพัฒนาการเรียนการสอน มหาวิทยาลัยรังสิต
Year: 2017
Subjects: Learning Achievement
Polya’s Problem Solving Model
Trigonometry
ผลสัมฤทธิ์ทางการเรียน
รูปแบบการแก้ปัญหาตามแนวคิดของโพลยา
วิชาตรีโกณมิติ

description: วารสารพัฒนาการเรียนการสอน, 11, 2, 12-22