cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaques
Creators: name: Li, Pingchao
name: Wang, Qian
name: He, Yizi
name: Yang, Chenchen
name: Zhang, Zhengyuan
name: Liu, Zijian
name: Liu, Bo
name: Yin, Li
name: Cui, Yilan
name: Hu, Peiyu
name: Liu, Yichu
name: Zheng, Pingqian
name: Wang, Wei
name: Qu, Linbing
name: Sun, Caijun
name: Guan, Suhua
name: Feng, Liqiang
name: Chen, Ling
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology
subject: Computational Biology

description: Prolonged infection and possible evolution of SARS-CoV-2 in patients living with uncontrolled HIV-1 infection highlight the importance of an effective vaccination regimen, yet the immunogenicity of COVID-19 vaccines and predictive immune biomarkers have not been well investigated. Herein, we report that the magnitude and persistence of antibody and cell-mediated immunity (CMI) elicited by an Ad5-vectored COVID-19 vaccine are impaired in SIV-infected macaques with high viral loads (> 105 genome copies per ml plasma, SIVhi) but not in macaques with low viral loads (< 105, SIVlow). After a second vaccination, the immune responses are robustly enhanced in all uninfected and SIVlow macaques. These responses also show a moderate increase in 70% SIVhi macaques but decline sharply soon after. Further analysis reveals that decreased antibody and CMI responses are associated with reduced circulating follicular helper T cell (TFH) counts and aberrant CD4/CD8 ratios, respectively, indicating that dysregulation of CD4+ T cells by SIV infection impairs the COVID-19 vaccine-induced immunity. Ad5-vectored COVID-19 vaccine shows no impact on SIV loads or SIV-specific CMI responses. Our study underscores the necessity of frequent booster vaccinations in HIV-infected patients and provides indicative biomarkers for predicting vaccination effectiveness in these patients.
sj-pdf-1-las-10.1177_00238309211030312 – Supplemental material for The Prosody of Two-Syllable Words in French-Speaking Monolingual and Bilingual Children: A Focus on Initial Accent and Final Accent
Creators: name: Kehoe, Margaret
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications
subject: Education
subject: 200399 Language Studies not elsewhere classified
subject: FOS: Languages and literature
subject: Sociology
subject: FOS: Sociology

description: Supplemental material, sj-pdf-1-las-10.1177_00238309211030312 for The Prosody of Two-Syllable Words in French-Speaking Monolingual and Bilingual Children: A Focus on Initial Accent and Final Accent by Margaret Kehoe in Language and Speech
sj-docx-1-sci-10.1177_00368504211035215 – Supplemental material for Inhibitory action ofhalogen-free fire retardants on combustion and volatile emission of bituminous components
Creators: name: Xia, Wenjing
name: Fan, Suying
name: Xu, Tao
Publisher: name: SAGE Journals
Year: 2021
Subjects: Biological Sciences not elsewhere classified

description: Supplemental material, sj-docx-1-sci-10.1177_00368504211035215 for Inhibitory action ofhalogen-free fire retardants on combustion and volatile emission of bituminous components by Wenjing Xia, Suying Fan and Tao Xu in Science Progress
Supplemental Material, sj-docx-1-smr-10.1177_00491241211031260 - Path Analysis for Binary Random Variables
Creators: name: Raggi, Martina
name: Stanghellini, Elena
name: Doretti, Marco
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology
subject: Sociology

description: Supplemental Material, sj-docx-1-smr-10.1177_00491241211031260 for Path Analysis for Binary Random Variables by Martina Raggi, Elena Stanghellini and Marco Doretti in Sociological Methods & Research
title: Dual LOX/COX Inhibition
title: A Novel Strategy to Prevent Neurovascular Leakage in Epilepsy
titleType: Subtitle
Creators: name: Sokola, Brent S.
Publisher: name: University of Kentucky Libraries
Year: 2018
Subjects: subject: Pharmacy and Pharmaceutical Sciences

description: Epilepsy affects 3.4 million patients in the USA and is characterized by recurring seizures. The blood-brain barrier is leaky in epilepsy and may contribute to seizure progression but the mechanisms which cause this leakage are not fully understood. We hypothesized that seizures trigger LOX- and COX-mediated blood-brain barrier leakage and that dual LOX/COX inhibition prevents barrier leakage in vivo. To test this hypothesis, we administered either the dual LOX/COX inhibitor licofelone or a combination of the 5-LOX inhibitor zileuton and the COX-2 inhibitor celecoxib to rats that experienced status epilepticus (SE). Serum and brain capillaries were isolated 48 hours after SE and serum S100β levels were measured and Texas Red™ leakage rates were determined. Dual inhibition of 5-LOX and COX prevented serum S100β elevations observed in SE rats in a dose-dependent manner with licofelone. Inhibition of 5-LOX and COX-2 with zileuton and celecoxib completely prevented serum S100β elevation. Texas Red™ leakage rates for SE rats were also reduced in a dose-depended manner with licofelone and reduced to control rates with zileuton and celecoxib. These data support our hypothesis that seizure-induced blood-brain barrier leakage is mediated by LOX and COX, and inhibition of these enzymes prevents barrier leakage.
Additional file 4 of Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer’s disease mice
Creators: name: Taylor, Xavier
name: Clark, Isaiah M.
name: Fitzgerald, Griffin J.
name: Oluoch, Herold
name: Hole, Justin T.
name: DeMattos, Ronald B.
name: Wang, Yaming
name: Pan, Feng
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Supplemental Fig. 4: Perivascular macrophages exhibit enrichment exclusively with amyloid+ vessels in 3D6 treated PDAPP Mice. (a) Triple immunofluorescence of amyloid+ (Thio-S, green) or amyloid− vessels, perivascular macrophage (CD169, red) and endothelial cells (PECAM-1, cyan) in PDAPP mice treated with IgG control. Thio-S, CD169 and PECAM-1 immunoreactivity overlay (Merge). (b) Quantification of CD169+ area (%) of IgG in amyloid+ or amyloid− vessels. (c) Triple immunofluorescence of amyloid+ (Thio-S, green) or amyloid− vessels, perivascular macrophage (CD169, red) and endothelial cells (PECAM-1, cyan) in PDAPP mice treated with 3D6. Thio-S, CD169 and PECAM-1 immunoreactivity overlay (Merge). (d) Quantification of CD169+ area (%) of 3D6 in amyloid+ or amyloid− vessels. The number of vessels analyzed was 8–10 per animal. Results are shown as ± SEM of n = 6 (mice). Asterisks indicate significant differences, where ***p < 0.001 by unpaired Student’s t test. Scale bar 10 μm merge or 5 μm inset, respectively.
LA57463 Site Record
Creators: name: DeVos, Jim
Publisher: name: Mariah Associates, Inc.
Year: 1986
Subjects: subject: Roosevelt (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/6797/roosevelt-county
subject: Melrose Air Force Range
valueUri: https://core.tdar.org/browse/geographic-keyword/85392/melrose-air-force-range
subject: New Mexico (State / Territory)
valueUri: https://core.tdar.org/browse/geographic-keyword/299/new-mexico-state-territory
subject: LA57463
valueUri: https://core.tdar.org/browse/site-name/134667/la57463
subject: Cannon AFB
valueUri: https://core.tdar.org/browse/other-keyword/170399/cannon-afb
subject: NRHP
valueUri: https://core.tdar.org/browse/other-keyword/9857/nrhp
subject: National Register of Historic Places
valueUri: https://core.tdar.org/browse/other-keyword/1572/national-register-of-historic-places
subject: Melrose Air Force Range
valueUri: https://core.tdar.org/browse/other-keyword/164551/melrose-air-force-range
subject: Site Records
valueUri: https://core.tdar.org/browse/other-keyword/43095/site-records
subject: MA-265D-48
valueUri: https://core.tdar.org/browse/other-keyword/170490/ma-265d-48

description: Site Record for LA57463 recorded 12/4/86. Includes hand-written version.
Additional file 1 of Non-canonical transcriptional start sites in E. coli O157:H7 EDL933 are regulated and appear in surprisingly high numbers
Creators: name: Zehentner, Barbara
name: Scherer, Siegfried
name: Neuhaus, Klaus
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 1
African swine fever virus – variants on the rise
Creators: name: Forth, Jan H.
name: Calvelage, Sten
name: Fischer, Melina
name: Hellert, Jan
name: Sehl-Ewert, Julia
name: Roszyk, Hanna
name: Deutschmann, Paul
name: Reichold, Adam
name: Lange, Martin
name: Thulke, Hans-Hermann
name: Sauter-Louis, Carola
name: Höper, Dirk
name: Mandyhra, Svitlana
name: Sapachova, Maryna
name: Beer, Martin
name: Blome, Sandra
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: African swine fever virus (ASFV), a large and complex DNA-virus circulating between soft ticks and indigenous suids in sub-Saharan Africa, has made its way into swine populations from Europe to Asia. This virus, causing a severe haemorrhagic disease (African swine fever) with very high lethality rates in wild boar and domestic pigs, has demonstrated a remarkably high genetic stability for over 10 years. Consequently, analyses into virus evolution and molecular epidemiology often struggled to provide the genetic basis to trace outbreaks while few resources have been dedicated to genomic surveillance on whole-genome level. During its recent incursion into Germany in 2020, ASFV has unexpectedly diverged into five clearly distinguishable linages with at least ten different variants characterized by high-impact mutations never identified before. Noticeably, all new variants share a frameshift mutation in the 3’ end of the DNA polymerase PolX gene O174L, suggesting a causative role as possible mutator gene. Although epidemiological modelling supported the influence of increased mutation rates, it remains unknown how fast virus evolution might progress under these circumstances. Moreover, a tailored Sanger sequencing approach allowed us, for the first time, to trace variants with genomic epidemiology to regional clusters. In conclusion, our findings suggest that this new factor has the potential to dramatically influence the course of the ASFV pandemic with unknown outcome. Therefore, our work highlights the importance of genomic surveillance of ASFV on whole-genome level, the need for high-quality sequences and calls for a closer monitoring of future phenotypic changes of ASFV.
Quantum Toroidal Superalgebras
Creators: name: Pereira Bezerra, Luan
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Algebraic structures in mathematical physics

description: We introduce the quantum toroidal superalgebra Em|n associated with the Lie superalgebra glm|n and initiate its study. For each choice of parity "s" of glm|n, a corresponding quantum toroidal superalgebra Es is defined.
To show that all such superalgebras are isomorphic, an action of the toroidal braid group is constructed.
The superalgebra Es contains two distinguished subalgebras, both isomorphic to the quantum affine superalgebra Uq sl̂m|n with parity "s", called vertical and horizontal subalgebras. We show the existence of Miki automorphism of Es, which exchanges the vertical and horizontal subalgebras.
If m and n are different and "s" is standard, we give a construction of level 1 Em|n-modules through vertex operators. We also construct an evaluation map from Em|n(q1,q2,q3) to the quantum affine algebra Uq gl̂m|n at level c=q3(m-n)/2.
LA 87371 Site Report
Creators: name: Fernandez, Rachel
Year: 2004
Subjects: subject: Roosevelt (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/6797/roosevelt-county
subject: Melrose Air Force Range
valueUri: https://core.tdar.org/browse/geographic-keyword/85392/melrose-air-force-range
subject: New Mexico (State / Territory)
valueUri: https://core.tdar.org/browse/geographic-keyword/299/new-mexico-state-territory
subject: LA 87371
valueUri: https://core.tdar.org/browse/site-name/118490/la-87371
subject: artifact scatter
valueUri: https://core.tdar.org/browse/material-type/176/artifact-scatter

description: Site Report for LA 87371. This site represents a limited activity or special use site. LA 87371 is ineligible for the NRHP.
LA 133074 Site Report
Creators: name: Fernandez, Rachel
Year: 2001
Subjects: subject: Roosevelt (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/6797/roosevelt-county
subject: Melrose Air Force Range
valueUri: https://core.tdar.org/browse/geographic-keyword/85392/melrose-air-force-range
subject: New Mexico (State / Territory)
valueUri: https://core.tdar.org/browse/geographic-keyword/299/new-mexico-state-territory
subject: LA 133074
valueUri: https://core.tdar.org/browse/site-name/118504/la-133074
subject: Trash Dump
valueUri: https://core.tdar.org/browse/material-type/1223/trash-dump

description: Site Report for LA 133074. LA 133074 is a Historic Period trash dump. LA 133074 is recommended as eligible for inclusion into the NRHP.
Additional file 1 of Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer’s disease mice
Creators: name: Taylor, Xavier
name: Clark, Isaiah M.
name: Fitzgerald, Griffin J.
name: Oluoch, Herold
name: Hole, Justin T.
name: DeMattos, Ronald B.
name: Wang, Yaming
name: Pan, Feng
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Supplemental Fig. 1: Reduced 3D6 immunoreactivity in anti-amyloid immunotherapy treated PDAPP mice. (a) Parenchymal and vascular amyloid Aβ deposits (brown, 3D6) across coronal sections of PDAPP mice treated with IgG or 3D6. (b) Quantification of 3D6+ area (%) in brain coronal sections of IgG or 3D6-treated mice. (c) Parenchymal Aβ deposits quantification of 3D6+ area (%) in brain coronal sections of IgG or 3D6-treated mice. (d) Vascular Aβ deposits quantification of 3D6+ area (%) in brain coronal sections of IgG or 3D6-treated mice. Each data point indicates an animal n = 20–25 (mice). All are representative images of 26-month-old PDAPP mice. Results are shown as ± SEM, asterisks indicate significant differences, where **p < 0.01 and *** p < 0.001 by unpaired Student’s t test. Scale bar 20 or 500 μm, respectively.
sj-pdf-1-gpi-10.1177_13684302211028293 – Supplemental material for The “Great Replacement” conspiracy: How the perceived ousting of Whites can evoke violent extremism and Islamophobia
Creators: name: Obaidi, Milan
name: Kunst, Jonas
name: Ozer, Simon
name: Kimel, Sasha Y.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, sj-pdf-1-gpi-10.1177_13684302211028293 for The “Great Replacement” conspiracy: How the perceived ousting of Whites can evoke violent extremism and Islamophobia by Milan Obaidi, Jonas Kunst, Simon Ozer and Sasha Y. Kimel in Group Processes & Intergroup Relations
Differential effects of Usutu and West Nile viruses on neuroinflammation, immune cell recruitment and blood-brain barrier integrity
Creators: name: Constant, Orianne
name: Maarifi, Ghizlane
name: Barthelemy, Jonathan
name: Martin, Marie-France
name: Tinto, Bachirou
name: Savini, Giovanni
name: Van de Perre, Philippe
name: Nisole, Sébastien
name: Simonin, Yannick
name: Salinas, Sara
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Neuroscience
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Usutu (USUV) and West Nile (WNV) viruses are two closely related Flavivirus belonging to Japanese encephalitis virus serogroup. Evidence of increased circulation of these two arbovirus now exist in Europe with neurological disorders reported in humans mainly for WNV, despite that the interaction and effects of viral infections on the neurovasculature are poorly described, notably for USUV. Using a human in vitro blood-brain barrier (BBB) and a mouse model, this study characterizes and compares the cerebral endothelial cell permissiveness, innate immunity and inflammatory responses and immune cell recruitment during infection by USUV and WNV. Both viruses are able to infect and cross the human BBB but with different consequences. We observed that WNV infect BBB cells resulting in significant endothelium dysregulation, potent neuroinflammation and immune cell recruitment, in agreement with previous studies. USUV, despite being able to infect BBB cells with higher replication rate than WNV, does not strongly affect endothelium integrity. Importantly, USUV also induces neuroinflammation, immune cell recruitment such as T lymphocytes, monocytes and dendritic cells (DCs) and was able to infect dendritic cells (DCs) more efficiently compared to WNV with greater propensity for BBB recruitment. DCs may have differential roles for neuroinvasion of the two related viruses.
LA57465 Site Record
Creators: name: DeVos, Jim
Publisher: name: Versar, Inc.
Year: 2015
Subjects: subject: Roosevelt (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/6797/roosevelt-county
subject: Melrose Air Force Range
valueUri: https://core.tdar.org/browse/geographic-keyword/85392/melrose-air-force-range
subject: New Mexico (State / Territory)
valueUri: https://core.tdar.org/browse/geographic-keyword/299/new-mexico-state-territory
subject: LA57465
valueUri: https://core.tdar.org/browse/site-name/134634/la57465
subject: Cannon AFB
valueUri: https://core.tdar.org/browse/other-keyword/170399/cannon-afb
subject: NRHP
valueUri: https://core.tdar.org/browse/other-keyword/9857/nrhp
subject: National Register of Historic Places
valueUri: https://core.tdar.org/browse/other-keyword/1572/national-register-of-historic-places
subject: Melrose Air Force Range
valueUri: https://core.tdar.org/browse/other-keyword/164551/melrose-air-force-range
subject: Site Records
valueUri: https://core.tdar.org/browse/other-keyword/43095/site-records

description: Site Record for LA57465 recorded 12/16/2015. The site is recommended not eligible for inclusion in the NRHP.
sj-pdf-1-teu-10.1177_13548166211034639 – Supplemental Material for Post-pandemic dark tourism in former epicenters
Creators: name: Cai, Yanting
name: Li, Gang
name: Liu, Chang
name: Wen, Long
Publisher: name: SAGE Journals
Year: 2021
Subjects: Economics
Hospitality Management

description: Supplemental Material, sj-pdf-1-teu-10.1177_13548166211034639 for Post-pandemic dark tourism in former epicenters by Yanting Cai, Gang Li, Chang Liu and Long Wen in Tourism Economics
LA57434 Site Record
Creators: name: DeVos, Jim
Publisher: name: Mariah Associates, Inc.
Year: 1986
Subjects: subject: Roosevelt (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/6797/roosevelt-county
subject: Melrose Air Force Range
valueUri: https://core.tdar.org/browse/geographic-keyword/85392/melrose-air-force-range
subject: New Mexico (State / Territory)
valueUri: https://core.tdar.org/browse/geographic-keyword/299/new-mexico-state-territory
subject: LA57434
valueUri: https://core.tdar.org/browse/site-name/134645/la57434
subject: Cannon AFB
valueUri: https://core.tdar.org/browse/other-keyword/170399/cannon-afb
subject: NRHP
valueUri: https://core.tdar.org/browse/other-keyword/9857/nrhp
subject: National Register of Historic Places
valueUri: https://core.tdar.org/browse/other-keyword/1572/national-register-of-historic-places
subject: Melrose Air Force Range
valueUri: https://core.tdar.org/browse/other-keyword/164551/melrose-air-force-range
subject: MA-265D-9
valueUri: https://core.tdar.org/browse/other-keyword/170503/ma-265d-9
subject: Site Records
valueUri: https://core.tdar.org/browse/other-keyword/43095/site-records

description: Site Record for LA57434 recorded 11/24/86.
SKELETAL DEFICITS IN MALE AND FEMALE MOUSE MODELS OF DOWN SYNDROME
Creators: name: Thomas, Jared
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Evolution of developmental systems
Developmental genetics (incl. sex determination)
Genetics not elsewhere classified

description: Down syndrome (DS) is a genetic disorder that results from triplication of human chromosome 21 (Hsa21) and occurs in around 1 in 1000 live births. All individuals with DS present with skeletal abnormalities typified by craniofacial features, short stature and low bone mineral density (BMD). Differences between males and females with DS suggest a sexual dimorphism in how trisomy affects skeletal deficits associated with trisomy 21 (Ts21). Previous investigations of skeletal abnormalities in DS have varied methodology, sample sizes and ages making the underlying causes of deficits uncertain. Mouse models of DS were used to characterize skeletal abnormalities, but the genetic and developmental origin remain unidentified. Over-expression Dyrk1a, found on Hsa21 and mouse chromosome 16 (Mmu16) has been linked to cognitive deficits and skeletal deficiencies. Dp1Tyb mice contain three copies of all of the genes on Mmu16 that are homologous to Hsa21, males and females are fertile, and therefore are an excellent model to test the hypothesis that gene dosage influences the sexual dimorphism of bone abnormalities in DS. Dp1Tyb at 6 weeks 16 weeks showed distinctive abnormalities in BMD, trabecular architecture, and reduced bone strength over time that occur generally through an interaction between sex and genotype. Increased gene dosage and sexual dimorphism in Dp1Tyb mice revealed distinct phenotypes in bone formation and resorption. To assess how Dyrk1a influences the activity and function of osteoblasts Ts65Dn female trisomic mice, female mice with a floxed Dyrk1a gene (Ts65Dn, Dyrk1afl/+) were be bred to Osx1-GFP::Cre+ mice to generate Ts65Dn animals with a reduced copy of Dyrk1a in mature osteoblast cells. Female Ts65Dn,Dyrk1a+/+/+ and Ts65Dn,Dyrk1a+/+/-displayed significant defects in both trabecular architecture and cortical geometry. Ultimate force was reduced in trisomic animals, suggesting whole bone and tissue level properties are not adversely affected by trisomy. Reduction of Dyrk1a functional copy number in female mice did not improve skeletal deficits in an otherwise trisomic animal. Dyrk1a may not alter osteoblast cellular activity in an autonomous manner in trisomic female mice. These data establish sex, gene dosage, skeletal site and age as important factors in skeletal development of the skeleton in DS mice, potentially paving the way for identification of the causal dosage-sensitive genes in both male and female animals.
sj-pdf-1-jla-10.1177_24726303211019394 – Supplemental material for Quantitative Confocal Microscopy for Grouping of Dose–Response Data: Deciphering Calcium Sequestration and Subsequent Cell Death in the Presence of Excess Norepinephrine
Creators: name: Manohar, Kuruba
name: Gare, Suman
name: Chel, Soumita
name: Dhyani, Vaibhav
name: Giri, Lopamudra
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-1-jla-10.1177_24726303211019394 for Quantitative Confocal Microscopy for Grouping of Dose–Response Data: Deciphering Calcium Sequestration and Subsequent Cell Death in the Presence of Excess Norepinephrine by Kuruba Manohar, Suman Gare, Soumita Chel, Vaibhav Dhyani and Lopamudra Giri in SLAS Technology
Mechanistic Understanding of Dissolution of Amorphous Solid Dispersions
Creators: name: Saboo, Sugandha
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Pharmaceutical sciences

description: As amorphous solid dispersions (ASDs) are more widely employed as a formulation strategy for poorly water-soluble drugs, there is a pressing need to increase the drug loading in these formulations. The drug loading is typically kept low to obtain the desired drug release rate, but often results in large or even multiple dosage units, which is undesirable from a patient compliance perspective. We have identified the cause of this conundrum to be the drug loading dependent dissolution mechanism of ASDs. At low drug loadings, the dissolution rate of ASDs is polymer-controlled, while at high drug loadings, the dissolution rate is drug-controlled and considerably slower. This phenomenon is most pronounced for ASDs with hydrophilic polymers, such as poly (vinylpyrrolidone-co-vinyl acetate) (PVPVA) and the change in dissolution mechanism from being polymer-controlled to drug-controlled has been attributed to water-induced amorphous-amorphous phase separation (AAPS) in higher drug loading ASD matrices of hydrophilic polymers. The drug loading limit for this switch has been found to be dependent on drug properties as well as drug-polymer interactions. Interestingly, drug-polymer hydrogen bonding interaction has been found to be detrimental and decrease the drug loading limit for polymer-controlled release while drug log P did not have any impact on this limit. Variable dissolution temperature studies indicated a detrimental impact on the polymer-controlled drug loading limit when the drug-rich phase (of phase separated ASD matrix) exists in a glassy state. ASDs with relatively hydrophobic polymers, such as hypromellose acetate succinate (HPMCAS), have been found to be polymer-controlled up to higher drug loadings. The mechanistic understanding obtained in this body of work can thus be adopted to develop strategies enabling ASD formulations with optimized performance and improved drug loading.
Organizing milk harvest: A producer perspective on infrastructure and human resources
Creators: name: Warvrin, William J.
Publisher: name: American Association of Bovine Practitioners  Conference Proceedings
Year: 2024
Subjects: commodity
direct costs
indirect costs
intangibles
success

description: One of the major considerations in operating a dairy production enterprise is the development and execution of a strategy for milk harvest. The production of milk as a business enterprise is generally governed by commodity based financial consid­erations. That is, the price of the final product is driven by the relationship between supply and demand. Both price and cost associated with the final product will be cyclical, and producers with lowest cost will, on average, gain market share over time just as those with high cost will lose market share over econom­ic cycles and may exit the business. Thus, the major consider­ation in organizing milk harvest is how strategic decisions will affect the final cost of the product. Some of the costs associated with the milking center can be considered direct costs while other aspects of the strategy can be considered indirect costs or opportunities. There are still other less tangible aspects of the harvest strategy that may not impact costs directly or indirectly at the milking center, but nonetheless have a bearing on what may be considered success in dairy production on a broader hu­man scale.
description: American Association of Bovine Practitioners Conference Proceedings, No. 56 (2023): 2023 Annual Conference Proceedings
LA182815 Site Record
Creators: name: DeVos, Jim
Publisher: name: Versar, Inc.
Year: 2015
Subjects: subject: Roosevelt (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/6797/roosevelt-county
subject: Melrose Air Force Range
valueUri: https://core.tdar.org/browse/geographic-keyword/85392/melrose-air-force-range
subject: New Mexico (State / Territory)
valueUri: https://core.tdar.org/browse/geographic-keyword/299/new-mexico-state-territory
subject: LA182815
valueUri: https://core.tdar.org/browse/site-name/134591/la182815
subject: Cannon AFB
valueUri: https://core.tdar.org/browse/other-keyword/170399/cannon-afb
subject: NRHP
valueUri: https://core.tdar.org/browse/other-keyword/9857/nrhp
subject: National Register of Historic Places
valueUri: https://core.tdar.org/browse/other-keyword/1572/national-register-of-historic-places
subject: Melrose Air Force Range
valueUri: https://core.tdar.org/browse/other-keyword/164551/melrose-air-force-range
subject: Site Records
valueUri: https://core.tdar.org/browse/other-keyword/43095/site-records

description: Site Record for LA182815 recorded 6/22/2015. The site is recommended as eligible for inclusion in the NRHP under Criterion D.
Temporal and coevolutionary analyses reveal the events driving the emergence and circulation of human mamastroviruses
Creators: name: Perez, Lester J.
name: Forberg, Kenn
name: Cloherty, Gavin A.
name: Berg, Michael G.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Characterized by high genetic diversity, broad host range, and resistance to adverse conditions, coupled with recent reports of neurotropic astroviruses circulating in humans, mamastroviruses pose a threat to public health. The current astrovirus classification system based on host source prevents determining whether strains with distinct tropism or virulence are emerging. By using integrated phylogeny, we propose a standardized demarcation of species and genotypes, with reproducible cut-off values that reconcile the pairwise sequence distribution, genetic distances between lineages, and the topological reconstruction of the Mamastrovirus genus. We further define the various links established by co-evolution and resolve the dynamics of transmission chains to identify host-jump events and the sources from which different mamastrovirus species circulating in humans have emerged. We observed that recombination is relatively infrequent and restricted to within genotypes. The well-known ‘human’ astrovirus, defined here as mamastrovirus species 7, has co-speciated with humans, while there have been two additional host-jumps into humans from distinct hosts. Newly defined species 6 genotype 2, linked to severe gastroenteritis in children, resulted from a marmot to human jump taking place ∼200 years ago while species 6 genotype 7 (MastV-Sp6Gt7), linked to neurological disease in immunocompromised patients, jumped from bovines only ∼50 years ago. Through demographic reconstruction, we determined that the latter reached coalescent viral population growth only 20 years ago and is evolving at a much higher evolutionary rate than other genotypes infecting humans. This study constitutes mounting evidence of MastV-Sp6Gt7 active circulation and highlights the need for diagnostics capable of detecting it.
Administrative Record for Melrose AFR Project to Locate 4 Cache Sites
Creators: name: DeVos, Jim
Year: 2013
Subjects: subject: Roosevelt (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/6797/roosevelt-county
subject: Melrose Air Force Range
valueUri: https://core.tdar.org/browse/geographic-keyword/85392/melrose-air-force-range
subject: New Mexico (State / Territory)
valueUri: https://core.tdar.org/browse/geographic-keyword/299/new-mexico-state-territory
subject: SHPO
valueUri: https://core.tdar.org/browse/other-keyword/89006/shpo
subject: Cannon AFB
valueUri: https://core.tdar.org/browse/other-keyword/170399/cannon-afb
subject: Administrative Record
valueUri: https://core.tdar.org/browse/other-keyword/170464/administrative-record
subject: Melrose Air Force Range
valueUri: https://core.tdar.org/browse/other-keyword/164551/melrose-air-force-range
subject: Cache Sites
valueUri: https://core.tdar.org/browse/other-keyword/19928/cache-sites

description: Administrative Record for Melrose AFR Project to locate 4 cache sites.
Additional file 6 of Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer’s disease mice
Creators: name: Taylor, Xavier
name: Clark, Isaiah M.
name: Fitzgerald, Griffin J.
name: Oluoch, Herold
name: Hole, Justin T.
name: DeMattos, Ronald B.
name: Wang, Yaming
name: Pan, Feng
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Supplemental Fig. 6 qPCR confirms dysregulated inflammatory signaling and extracellular matrix remodeling genes. (a) Relative expression of Pdpn in BMDM activated by IgG2a vs. control LALAPG (b) Relative expression of Timp1 in BMDM activated by IgG2a vs. control LALAPG (c) Relative expression of Msr1 in BMDM activated by IgG2a vs. control LALAPG. Data was normalized to the levels of actin mRNA. Relative quantitation was performed using 2−ΔΔCt (fold change) method. Results are shown as the mean ± SEM of n = 3 (independent cultures). Asterisks indicate significant differences, where * p < 0.05 and ** p < 0.01.
Supplemental Material, sj-doc-1-osj-10.1177_23094990211027391 - Obesity is a risk factor for epidural lipomatosis: a meta-analysis
Creators: name: Zhang, Bi
name: Yuan, Haifeng
name: Hu, Lihong
name: Saad, Muhammad
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences
subject: 110323 Surgery

description: Supplemental Material, sj-doc-1-osj-10.1177_23094990211027391 for Obesity is a risk factor for epidural lipomatosis: a meta-analysis by Bi Zhang, Haifeng Yuan, Lihong Hu and Muhammad Saad in Journal of Orthopaedic Surgery
LA57432 Site Evaluation Forms
Creators: name: DeVos, Jim
Publisher: name: Versar, Inc.
Year: 2015
Subjects: subject: Roosevelt (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/6797/roosevelt-county
subject: Melrose Air Force Range
valueUri: https://core.tdar.org/browse/geographic-keyword/85392/melrose-air-force-range
subject: New Mexico (State / Territory)
valueUri: https://core.tdar.org/browse/geographic-keyword/299/new-mexico-state-territory
subject: LA57432
valueUri: https://core.tdar.org/browse/site-name/134625/la57432
subject: Cannon AFB
valueUri: https://core.tdar.org/browse/other-keyword/170399/cannon-afb
subject: Melrose Air Force Range
valueUri: https://core.tdar.org/browse/other-keyword/164551/melrose-air-force-range

description: Site Record for LA57431 recorded 12/16/2015.
Changes in the characteristics and outcomes of COVID-19 patients from the early pandemic to the delta variant epidemic: a nationwide population-based study
Creators: name: Miyashita, Koichi
name: Hozumi, Hironao
name: Furuhashi, Kazuki
name: Nakatani, Eiji
name: Inoue, Yusuke
name: Yasui, Hideki
name: Karayama, Masato
name: Suzuki, Yuzo
name: Fujisawa, Tomoyuki
name: Enomoto, Noriyuki
name: Inui, Naoki
name: Ojima, Toshiyuki
name: Suda, Takafumi
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: The coronavirus disease 2019 (COVID-19) pandemic has dramatically changed because of virus mutations, vaccine dissemination, treatment development and policies, among other factors. These factors have a dynamic and complex effect on the characteristics and outcomes of patients. Therefore, there is an urgent need to understand those changes and update the evidence. We used a large-scale real-world data set of 937,758 patients with COVID-19 from a nationwide claims database that included outpatients and inpatients in Japan to investigate the changes in their characteristics, outcomes and risk factors for severity/mortality from the early pandemic to the delta variant-predominant waves. The severity of COVID-19 was defined according to the modified World Health Organization clinical-progression ordinal scale. With changing waves, mean patient age decreased, and proportion of patients with comorbidities decreased. The incidences of “severe COVID-19 or death (i.e. ≥severe COVID-19)” and “death” markedly declined (5.0% and 2.9%, wild-type-predominant; 4.6% and 2.2%, alpha variant-predominant and 1.4% and 0.4%, delta variant-predominant waves, respectively). Across the wave shift, risk factors for ≥ severe COVID-19 and death, including older age, male, malignancy, congestive heart failure and chronic obstructive pulmonary disease, were largely consistent. The significance of some factors, such as liver disease, varied as per the wave. This study, one of the largest population-based studies on COVID-19, showed that patient characteristics and outcomes changed during the waves. Risk factors for severity/mortality were similar across all waves, but some factors were inconsistent. These data suggest that the clinical status of COVID-19 will change further with the coming epidemic wave.
Additional file 7 of Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer’s disease mice
Creators: name: Taylor, Xavier
name: Clark, Isaiah M.
name: Fitzgerald, Griffin J.
name: Oluoch, Herold
name: Hole, Justin T.
name: DeMattos, Ronald B.
name: Wang, Yaming
name: Pan, Feng
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Supplemental Fig. 7 Bone marrow-derived macrophages plated with LALAPG have no significant differential gene expression from non-treatment group. (a) Schematic diagram showing macrophages treated with immunodeficient LALAPG control antibodies. (b) Volcano plots showing not significantly differentially expressed genes in LALAPG activated macrophages vs. control nontreated macrophages. Horizontal line values correspond to p-value < 0.01(solid), p-value < 0.05 (dashed).
Melrose Project Daily Records, T1S R29 E12
Creators: name: DeVos, Jim
Publisher: name: Agency for Conservation Archaeology - Eastern New Mexico University
Year: 1995
Subjects: subject: Roosevelt (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/6797/roosevelt-county
subject: Melrose Air Force Range
valueUri: https://core.tdar.org/browse/geographic-keyword/85392/melrose-air-force-range
subject: New Mexico (State / Territory)
valueUri: https://core.tdar.org/browse/geographic-keyword/299/new-mexico-state-territory
subject: Cannon AFB
valueUri: https://core.tdar.org/browse/other-keyword/170399/cannon-afb
subject: Gammil Well
valueUri: https://core.tdar.org/browse/other-keyword/170419/gammil-well
subject: Daily Records
valueUri: https://core.tdar.org/browse/other-keyword/170449/daily-records
subject: Melrose Air Force Range
valueUri: https://core.tdar.org/browse/other-keyword/164551/melrose-air-force-range
subject: T1SR29E12
valueUri: https://core.tdar.org/browse/other-keyword/170538/t1sr29e12

description: Daily records for Gamill Well - T1S R29 E12
Designing Titanium Alloys with Enhanced Biological Functionalities Using Additive Manufacturing
Creators: name: Ciliveri, Sushant
Publisher: name: Washington State University
Year: 2023
Subjects: Additive manufacturing
Antibacterial
Biocompatibility
Orthopedic
Titanium

description: With over 7 million yearly orthopedic surgeries in the US alone, the attention towards metallic implant materials for orthopedic applications has gained much importance in the past 2 decades. The advent of metal additive manufacturing (AM) aiding the processing of patient-specific implants has proved to be a boon for the implant manufacturing sector. Challenges persist with delayed implant-host bone tissue integration and bacterial infections at the implant site. Addressing these issues requires revision surgery. However, elderly patients with immunocompromised bone health cannot undergo the physical toll of revision surgeries on their overall health, reducing their life expectancy. The long-term stability of an implant in vivo depends on its early-stage osseointegration. Titanium is the ultimate choice of metallic biomaterial, and is bio-inert in nature. There is an unmet need in the orthopedic metallic implant sector with enhanced biological performance in vivo, leading to accelerated bone-tissue growth on the implant surface. Current strategies include structural modification (surface porosities) and material chemistry intervention to aid accelerated bone-tissue integration. Along with the biological performance, the processing feasibility via AM and mechanical integrity of the alloy designs are essential parameters. This dissertation focuses on three significant aspects of titanium-based orthopedic implants: structure, material chemistry, and manufacturability via AM. The dissertation begins from the surface of an implant and is driven into bulk material modification. The dissertation further discusses a Ti-alloy design to replace the commercially used Ti6Al4V alloy for orthopedic applications, starting with exploring the structural integrity of porous surface coatings and modifying its material chemistry. Surface chemistry modifications include the addition of osteogenic MgO and angiogenic SiO2, and antibacterial Cu to Ti, showing superior in vivo biological performance to commercially pure titanium (CpTi). The first step in designing the bulk implant material was to reduce the Al and V contents in Ti6Al4V to design an alloy, Ti3Al2V, specifically for the orthopedic industry. Bioactive Ta and antibacterial Cu were added to this alloy, proving superior in vivo performance without significant degradation in mechanical strength compared to Ti6Al4V. Additive manufacturing of this designed Ti-Ta-Cu alloy was explored via print-parameter optimization with higher energy densities since Ta and Cu need higher energy input for laser-based AM.
sj-pdf-1-imr-10.1177_03000605211032849 - Supplemental material for The small molecule kobusone can stimulate islet β-cell replication in vivo
Creators: name: Choi, Jin woo
name: Joo, Jin-deok
name: In, Jang hyeok
name: Kim, Daewoo
name: Kim, Yongshin
name: Choi, Seung Tae
name: Kim, Jung Han
name: Jung, Hong Soo
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: Cardiology
subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine
subject: 110305 Emergency Medicine
subject: 110306 Endocrinology
subject: 110308 Geriatrics and Gerontology
subject: 110904 Neurology and Neuromuscular Diseases
subject: 111099 Nursing not elsewhere classified
subject: 111199 Nutrition and Dietetics not elsewhere classified
subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: 110314 Orthopaedics
subject: 110604 Sports Medicine
subject: 110315 Otorhinolaryngology
subject: 111702 Aged Health Care
subject: 111403 Paediatrics
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 110203 Respiratory Diseases
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology
subject: 110323 Surgery

description: Supplemental material, sj-pdf-1-imr-10.1177_03000605211032849 for The small molecule kobusone can stimulate islet β-cell replication in vivo by Jin woo Choi, Jin-deok Joo, Jang hyeok In, Daewoo Kim, Yongshin Kim, Seung Tae Choi, Jung Han Kim and Hong Soo Jung in Journal of International Medical Research
More Usable Flops Per Watt: A Story About A Highly-Optimized Correlation Function Code
Creators: name: Sinha, Manodeep
name: Garrison, Lehman
Publisher: name: Zenodo
Year: 2018
Subjects: pyastro18
galaxies
large-scale-structure
cosmology
hpc
python
optimization
astronomy

description: Galaxy clustering is determined by a combination of cosmological parameters, non-linear gravitational collapse, and the physics of galaxy formation. Consequently, comparing the observed and predicted correlation functions provides a stringent test for galaxy formation theories as well as precise values of cosmological parameters. However, quantifying the clustering strength requires computing pair-wise separations -- an inherently quadratic process. Since large galaxy surveys, and consequently the theoretical models, contain millions of galaxies, computing the correlation function becomes a bottleneck in the analysis pipeline. With upcoming surveys like Large Synoptic Survey Telescope and the Square Kilometre Array (SKA), the number of detected sources will increase many-folds, and will exacerbate the bottleneck. I will show that software tuned to the underlying CPU hardware can speed up the calculation by almost two orders of magnitude. For modern CPUs, such a tuning involves proper utilization of the cache hierarchy, vectorized code targeting the Single Instruction Multiple Data (SIMD) capable wide vector registers as well as many-core parallelization. Here I present Corrfunc -- a suite of OpenMP-parallelized clustering codes that exploit current CPU micro-architecture with custom Advanced Vector Extensions (AVX) and Streaming SIMD Extensions (SSE) intrinsics. Corrfunc can compute a variety of correlation functions for source positions in either a Cartesian geometry (i.e., generated from cosmological simulations) or for positions on the sky. The algorithm within Corrfunc can be easily adapted to a variety of different measurements and has already been implemented for nearest neighbour searches, group finding in galaxy surveys, weak lensing measurements etc. By design, Corrfunc is highly optimized and can compute wprp for mathcal{O}(1 million) galaxies in ~ 6 seconds on a post-2011 CPU, which is at least a factor of few faster than existing public correlation function routines. Corrfunc is covered by a suite of tests, extensive documentation and is publicly available at https://github.com/manodeep/Corrfunc.
Melrose Project Daily Records, T1N R31 E27
Creators: name: DeVos, Jim
Publisher: name: Agency for Conservation Archaeology - Eastern New Mexico University
Year: 1994
Subjects: subject: Roosevelt (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/6797/roosevelt-county
subject: Melrose Air Force Range
valueUri: https://core.tdar.org/browse/geographic-keyword/85392/melrose-air-force-range
subject: New Mexico (State / Territory)
valueUri: https://core.tdar.org/browse/geographic-keyword/299/new-mexico-state-territory
subject: Cannon AFB
valueUri: https://core.tdar.org/browse/other-keyword/170399/cannon-afb
subject: Daily Records
valueUri: https://core.tdar.org/browse/other-keyword/170449/daily-records
subject: Melrose Air Force Range
valueUri: https://core.tdar.org/browse/other-keyword/164551/melrose-air-force-range
subject: Tule Lake
valueUri: https://core.tdar.org/browse/other-keyword/170517/tule-lake
subject: T1NR31E27
valueUri: https://core.tdar.org/browse/other-keyword/170523/t1nr31e27

description: Daily records for Tolar Southeast - T1N R31 E27