cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
ROLE OF JNK AND CHOP IN THE PATHOGENESIS OF LIVER DISEASE DUE TO Z ALPHA-1 ANTITRYPSIN
Creators: name: ATTANASIO, SERGIO
Publisher: name: Universit� degli Studi di Milano
Year: 2019

description: Alpha-1 antitrypsin (AAT) deficiency is a genetic disease that can affect both the lung and the liver. The vast majority of patients harbor a mutation in the SERPINA1 gene resulting in a single substitution from glutamic acid to lysine at amino acid position 342 (p.E342K). The AAT encoded by the Z allele (ATZ) is not properly folded and accumulates in the endoplasmic reticulum (ER) of hepatocytes resulting in liver disease through a gain of function mechanism. The liver disease is a prototype of conformational disorder due to protein misfolding and aggregation. Intracellular retention of ATZ triggers a complex injury cascade including autophagy, ER-stress and other mechanisms. Nevertheless, several aspects of the disease pathogenesis are still unclear. I found that ATZ induces activation of c-JUN N-terminal kinase (JNK) and c-JUN signaling in livers of a mouse model (PiZ mice) of the disease. JNK activation was confirmed in human livers of patients homozygous for the Z allele with severe liver disease requiring hepatic transplantation. In mice, genetic ablation of Jnk1 or Jnk2 decreased ATZ levels by reducing c-JUN mediated SERPINA1 expression. Moreover, I have found up-regulation of genes associated with response to ER stress in PiZ mouse livers by expression array profiling. Among the differentially expressed genes, I focused on the CCAAT/Enhancer-Binding Protein Homologous Protein (Chop) that was significantly up-regulated in both mouse and human livers expressing ATZ. To investigate the role of CHOP in ATZ-induced liver damage, I crossed PiZ with Chop null (Chop-/-) mice. Genetic ablation of Chop resulted in a marked reduction of hepatic ATZ levels in juvenile PiZ mice. SERPINA1 mRNA levels in livers of PiZ/Chop-/- mice were also significantly reduced compared to PiZ controls, suggesting that CHOP induces ATZ accumulation by increasing SERPINA1 transcription. CHOP was indeed found to up-regulate SERPINA1 expression through binding with C/EBP? and c-JUN on SERPINA1 regulatory elements. So far, JNK and CHOP have been involved in the pathogenesis of several liver disorders but not in hepatic disease induced by ATZ. The results of my studies show that JNK and CHOP are important players in the disease pathogenesis and are novel therapeutic targets.
Detection of Gamma-ray Emission from the Eta-Carinae Region
Creators: name: Tavani, M.
name: Sabatini, S.
name: Pian, E.
name: Bulgarelli, A.
name: Caraveo, P.
name: Viotti, R. F.
name: Corcoran, M. F.
name: Giuliani, A.
name: Pittori, C.
name: Verrecchia, F.
name: Vercellone, S.
name: Mereghetti, S.
name: Argan, A.
name: Barbiellini, G.
name: Boffelli, F.
name: Cattaneo, P. W.
name: Chen, A. W.
name: Cocco, V.
name: D'Ammando, F.
name: Costa, E.
name: De Paris, G.
name: Del Monte, E.
name: Di Cocco, G.
name: Donnarumma, I.
name: Evangelista, Y.
name: Ferrari, A.
name: Feroci, M.
name: Fiorini, M.
name: Froysland, T.
name: Fuschino, F.
name: Galli, M.
name: Gianotti, F.
name: Labanti, C.
name: Lapshov, I.
name: Lazzarotto, F.
name: Lipari, P.
name: Longo, F.
name: Marisaldi, M.
name: Mastropietro, M.
name: Morelli, E.
name: Moretti, E.
name: Morselli, A.
name: Pacciani, L.
name: Pellizzoni, A.
name: Perotti, F.
name: Piano, G.
name: Picozza, P.
name: Pilia, M.
name: Porrovecchio, G.
name: Pucella, G.
name: Prest, M.
name: Rapisarda, M.
name: Rappoldi, A.
name: Rubini, A.
name: Soffitta, P.
name: Trifoglio, M.
name: Trois, A.
name: Vallazza, E.
name: Vittorini, V.
name: Zambra, A.
name: Zanello, D.
name: Santolamazza, P.
name: Giommi, P.
name: Colafrancesco, S.
name: Antonelli, L. A.
name: Salotti, L.
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present the results of extensive observations by the gamma-ray AGILE satellite of the Galactic region hosting the Carina nebula and the remarkable colliding wind binary Eta Carinae (Eta Car) during the period 2007 July to 2009 January. We detect a gamma-ray source (1AGL J1043-5931) consistent with the position of Eta Car. If 1AGL J1043-5931 is associated with the Eta Car system our data provide the long sought first detection above 100 MeV of a colliding wind binary. The average gamma-ray flux above 100 MeV and integrated over the pre-periastron period 2007 July to 2008 October is F = (37 +/- 5) x 10-8 ph cm-2 s-1 corresponding to an average gamma-ray luminosity of L = 3.4 x 10^34 erg s-1 for a distance of 2.3 kpc. We also report a 2-day gamma-ray flaring episode of 1AGL J1043-5931 on 2008 Oct. 11-13 possibly related to a transient acceleration and radiation episode of the strongly variable shock in the system.
description: 5 pages, 4 figure, accepted for publication in ApJ Letters
title: Anatomy of a Rupture: Identity Maintenance in the 1844 Latter-day Saint Reform Sect
Creators: name: Call, Robert M.
Publisher: name: Utah State University
Year: 2017

description: Dissent riddled Mormonism almost from the day of its inception. Competing prophets and dissatisfied adherents challenged Joseph Smith’s leadership of The Church of Jesus Christ of Latter-day Saints. Perhaps the most serious of Smith’s challengers was the dissent of his counselor William Law. In 1844, Law confronted Smith over the implementation of the latter’s doctrinal innovations (particularly plural marriage) and Zion building activities in Nauvoo, Illinois. At the height of the dissent movement, anti-Mormon citizens in the region (some say inflamed by Law’s newspaper the Nauvoo Expositor)assassinated Smith. The assassination caused a religious rupture in Mormonism called the Succession Crisis.
This thesis examines identity formation, maintenance, and evolution in Law’s 1844 dissenting group. It argues that several factors, notably estrangement and social networks, were key in forming the group’s identity. As other scholars acknowledge, the group intended on a Mormon reformation. It also argues that a more accurate understanding of the dissent organization is one of an extralegal internal reform body rather than (as current scholarship puts forth) an external separatist church. The reform sect maintained their distinct identity during the closing months of 1844, but evolved into the 1845 Church of Christ that Sidney Rigdon helmed. Lastly, this thesis surveys the reformers’ navigation of a turbulent religious climate and offers some analysis on why those reformers most committed to Mormonism ultimately rested in the Reorganized Church of Jesus Christ of Latter Day Saints.
Additional file 1 of A review of economic evaluations of health care for people at risk of psychosis and for first-episode psychosis
Creators: name: Shields, Gemma E.
name: Buck, Deborah
name: Varese, Filippo
name: Yung, Alison R.
name: Thompson, Andrew
name: Husain, Nusrat
name: Broome, Matthew R.
name: Upthegrove, Rachel
name: Byrne, Rory
name: Davies, Linda M.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Additional file 1.
Dave Brown: Ringing in a New Era of Recording
Creators: name: Oxford Archaeology
Publisher: name: Archaeology Data Service
Year: 2016

description: This resource is a single blog post created as part of the Day of Archaeology initiative. The Day of Archaeology project aimed to provide a window into the daily lives of archaeologists from all over the world. The project asked people working, studying or volunteering in the archaeological world to participate in a 'Day of Archaeology' each year by recording their day and sharing it through text, images or video on the Day of Archaeology blog.
The project asked anyone with a personal, professional or voluntary interest in archaeology to get involved, and help highlight the reasons why archaeology is vital to protect the past and inform our futures. The resulting Day of Archaeology project archive demonstrates the wide variety of work the archaeological profession undertakes day-to-day across the globe, and helps to raise public awareness of the relevance and importance of archaeology to the modern world.
The first ever Day of Archaeology was held in 2011 and, since then, the project had thousands of archaeologists take part in the event, from those working in the field through to specialists working in laboratories and behind computers. The last Day of Archaeology was on Friday 28th July 2017.
Additional file 1 of Implementation of a campus-based and peer-delivered HIV self-testing intervention to improve the uptake of HIV testing services among university students in Zimbabwe: the SAYS initiative
Creators: name: Mukora-Mutseyekwa, Fadzai
name: Mundagowa, Paddington Tinashe
name: Kangwende, Rugare Abigail
name: Murapa, Tsitsi
name: Tirivavi, Mandla
name: Mukuwapasi, Waraidzo
name: Tozivepi, Samantha Nokuthula
name: Uzande, Charles
name: Mutibura, Queen
name: Chadambuka, Elizabeth Marian
name: Machinga, Mazvita
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1. HIV self testing project: training of trainers facilitators manual hand book.
Cantiere-Scuola Vetus Litus, progetto di restauro e formazione
Creators: name: Tosi, Maria Elena
Publisher: name: Archaeology Data Service
Year: 2016

description: This resource is a single blog post created as part of the Day of Archaeology initiative. The Day of Archaeology project aimed to provide a window into the daily lives of archaeologists from all over the world. The project asked people working, studying or volunteering in the archaeological world to participate in a 'Day of Archaeology' each year by recording their day and sharing it through text, images or video on the Day of Archaeology blog.
The project asked anyone with a personal, professional or voluntary interest in archaeology to get involved, and help highlight the reasons why archaeology is vital to protect the past and inform our futures. The resulting Day of Archaeology project archive demonstrates the wide variety of work the archaeological profession undertakes day-to-day across the globe, and helps to raise public awareness of the relevance and importance of archaeology to the modern world.
The first ever Day of Archaeology was held in 2011 and, since then, the project had thousands of archaeologists take part in the event, from those working in the field through to specialists working in laboratories and behind computers. The last Day of Archaeology was on Friday 28th July 2017.
Continuous microbiological leaching of a zinc sulphide concentrate
Creators: name: Gormely, Lynton Spencer
Publisher: name: University of British Columbia
Year: 2011

description: A zinc sulphide concentrate was leached microbiologically by Thiobacillus ferrooxidans in a continuous stirred tank reactor. A model was developed to predict the leaching kinetics when the bacterial growth rate was not limited by any substrate other than the zinc concentrate, and it was modified to explain the observed results. It was possible to obtain stable steady-states over a range of dilution rates. Because a solid substrate was used, the specific growth rate of the bacteria was not a unique function of the substrate concentration, and conventional continuous culture theory based on the Monod equation therefore did not apply to this system. The bacterial concentration did not limit the growth rates under the conditions of these experiments. The leaching rates and bacterial growth rates are thus first order in mineral surface area concentration. The highest specific growth rate observed was 0.1038 hr⁻¹; the highest oxygen uptake coefficient (Q[sub O₂ ](N)) calculated was 7650. Both of these values are higher than any reported previously for T. ferrooxidans growing on a solid substrate. The highest zinc release rate obtained was 1.3 g/l-hr. None of these values is necessarily the maximum achievable. Total carbon and non-distillable ammonium ion concentrations proved to be satisfactory measures of biomass concentration. Yield coefficients calculated from these data were constant for the dilution rates investigated, indicating a low maintenance energy requirement for the organism. The value of the net ammonium ion yield constant suggests that addition of ammonium ion above the level present in the medium 9K of Silverman and Lundgren should be beneficial when zinc concentrations exceed 68 g/1. Percentage zinc extractions increased with decreasing dilution rate, but sufficiently low dilution rates to achieve extractions which would be competitive with conventional processes were not used. Recommendations are given for achieving competitive extractions by altering the process configuration. When the percentage zinc extraction was known for one dilution rate, it was possible to use a calculation method given by Levenspiel to predict the extractions at other dilution rates.
Additional file 1 of Ideational factors associated with net care behaviour: a multi-country analysis
Creators: name: Kumoji, E. ‘Kuor
name: Awantang, Grace N.
name: Toso, Michael
name: Kamara, Diarra
name: Bleu, Thérèse
name: Lahai, Wani
name: Sillah-Kanu, Musa
name: Dosso, Abdul
name: Achu, Dorothy
name: Babalola, Stella
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Table A1. Question and statements used to measure ideational independent variables. Table describes the questions and statements used to create binary independent ideational variables used in the paper’s multilevel analysis.
XMM-Newton unveils the complex iron K alpha region of Mrk 279
Creators: name: Costantini, E.
name: Kaastra, J. S.
name: Korista, K.
name: Ebrero, J.
name: Arav, N.
name: Kriss, G.
name: Steenbrugge, K. C.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present the results of a ~160 ks-long XMM-Newton observation of the Seyfert 1 galaxy Mrk 279. The spectrum shows evidence of both broad and narrow emission features. The Fe K alpha line may be equally well explained by a single broad Gaussian (FWHM~10,000 km/s) or by two components: an unresolved core plus a very broad profile (FWHM~14,000 km/s). For the first time we quantified, via the "locally optimally emitting cloud" model, the contribution of the broad line region (BLR) to the absolute luminosity of the broad component of the Fe K alpha at 6.4 keV. We find that the contribution of the BLR is only ~3%. In the two-line component scenario, we also evaluated the contribution of the highly ionized gas component, which produces the FeXXVI line in the iron K region. This contribution to the narrow core of the Fe K alpha line is marginal <0.1%. Most of the luminosity of the unresolved, component of Fe K alpha may come from the obscuring torus, while the very-broad associated component may come from the accretion disk. However, models of reflection by cold gas are difficult to test because of the limited energy band. The FeXXVI line at 6.9 keV is consistent to be produced in a high column density (N_H~10^23 cm^{-2}), extremely ionized (logξ~5.5-7) gas. This gas may be a highly ionized outer layer of the torus.
description: 10 pages, 9 figures, accepted for publication in Astronomy and Astrophysics
title: Ultra-Wideband Transceiver with Error Correction for Cortical Interfaces in NanometerCMOS Process
Creators: name: Luo, Yi
Publisher: name: Utah State University
Year: 2017

description: This dissertation reports a high-speed wideband wireless transmission solution for the tight power constraints of cortical interface application. The proposed system deploysImpulse Radio Ultra-wideband (IR-UWB) technique to achieve very high-rate communication. However, impulse radio signals suffer from significant attenuation within the body,and power limitations force the use of very low-power receiver circuits which introduce additional noise and jitter. Moreover, the coils’ self-resonance has to be suppressed to minimize the pulse distortion and inter-symbol interference, adding significant attenuation. To compensate these losses, an Error correction code (ECC) layer is added for functioning reliably to the system. The performance evaluation is made by modeling a pair of physically fabricated coils, and the results show that the ECC is essential to obtain the system’s reliability.
Furthermore, the gm/ID methodology, which is based on the complete exploration ofall inversion regions that the transistors are biased, is studied and explored for optimizingthe system at the circuit-level. Specific focuses are on the RF blocks: the low noise am-plifier (LNA) and the injection-locked voltage controlled oscillator (IL-VCO). Through the analytical deduction of the circuit’s features as the function of the gm/ID for each transistor, it is possible to select the optimum operating region for the circuit to achieve the target specification. Other circuit blocks, including the phase shifter, frequency divider,mixer, etc. are also described and analyzed. The prototype is fabricated in a 65-nm CMOS(Complementary Metal-Oxide-Semiconductor) process.
BURST-MODE MOLECULAR FILTERED RAYLEIGH SCATTERING FOR GAS-DYNAMIC MEASUREMENTS
Creators: name: Braun, Amanda Marie
Publisher: name: Purdue University Graduate School
Year: 2023
Subjects: classificationCode: 401799
subject: Mechanical engineering not elsewhere classified

description: From transonic to hypersonic regimes, the characterization of high-speed flow dynamics is critical for the development, testing, and improvement of launch and reentry vehicles, boost-glide vehicles, and thermal protection systems. The design of this technology often relies on computational/empirical models for predictions which make quantitative thermodynamic measurements crucial for numerical validation. Laser diagnostic techniques facilitate non-intrusive, in situ measurements of fluid dynamic properties as well as visualization of flows, shocks, and boundary layer interactions. However, many diagnostics rely on seeding the flow with foreign materials to make measurements, such as the application of particle image velocimetry (PIV), Doppler global velocimetry (DGV), and planar laser-induced fluorescence (PLIF). Molecular filtered Rayleigh scattering (FRS) diagnostics are attractive for flow characterization due to the fact that pressure, temperature, density and velocity measurements can be made directly from air or N2 molecules without the need for seeding materials. The development of the burst-mode laser (BML) has enabled high-energy pulses generated at the rates necessary to resolve phenomena such as instabilities in boundary-layers and shock-wave evolution using Rayleigh scattering methods. The goal of this dissertation is to advance molecular burst-mode FRS for quantitative, high resolution, multi-parameter measurements. For fixed-wavelength FRS measurements, the spectral characteristics of a BML system were investigated and improved by integrating an etalon for spectral-gating. For multi-parameter measurements, two strategies for wavelength-agility, the ability to quickly switch between two or more laser wavelengths, of the BML were explored: frequency-scanning and frequency-shifting. The frequency-scanning FRS (FS-FRS) technique measurement rate was increased to 1 kHz and demonstrated for 1-ms pressure, temperature, and radial velocity measurements in an underexpanded jet flow. Building upon this, an acousto-optic modulator-based method was implemented to generate frequency-shifted pulses. The rapid frequency-shifting increased the effective FRS multi-parameter measurement rate to 25 kHz and planar pressure, temperature, and radial velocity measurements were captured in an overexpanded jet flow. Finally, design tools for the laser configuration of wavelength-agile FRS were developed for the optimization of relative absolute measurement errors.
Jülich Supercomputing Centre - Energy Optimization - RES Users Conference
Creators: name: Manzano, Cristina
name: Eickermann, Thomas
name: Frech, Peter
name: Fieseler, Thomas
name: Suarez, Estela
name: Graf, Stephan
Publisher: name: Forschungzentrum Jülich
Year: 2023

description: 17th RES USERS CONFERENCE, Barcelona, Spain, 13 Sep 2023 - 14 Sep 2023
Archaeology is an endless discussion
Creators: name: Guermandi, Maria Pia
Publisher: name: Archaeology Data Service
Year: 2016

description: This resource is a single blog post created as part of the Day of Archaeology initiative. The Day of Archaeology project aimed to provide a window into the daily lives of archaeologists from all over the world. The project asked people working, studying or volunteering in the archaeological world to participate in a 'Day of Archaeology' each year by recording their day and sharing it through text, images or video on the Day of Archaeology blog.
The project asked anyone with a personal, professional or voluntary interest in archaeology to get involved, and help highlight the reasons why archaeology is vital to protect the past and inform our futures. The resulting Day of Archaeology project archive demonstrates the wide variety of work the archaeological profession undertakes day-to-day across the globe, and helps to raise public awareness of the relevance and importance of archaeology to the modern world.
The first ever Day of Archaeology was held in 2011 and, since then, the project had thousands of archaeologists take part in the event, from those working in the field through to specialists working in laboratories and behind computers. The last Day of Archaeology was on Friday 28th July 2017.
Worth every penny: a numismatist s view
Creators: name: White, Steve
Publisher: name: Archaeology Data Service
Year: 2016

description: This resource is a single blog post created as part of the Day of Archaeology initiative. The Day of Archaeology project aimed to provide a window into the daily lives of archaeologists from all over the world. The project asked people working, studying or volunteering in the archaeological world to participate in a 'Day of Archaeology' each year by recording their day and sharing it through text, images or video on the Day of Archaeology blog.
The project asked anyone with a personal, professional or voluntary interest in archaeology to get involved, and help highlight the reasons why archaeology is vital to protect the past and inform our futures. The resulting Day of Archaeology project archive demonstrates the wide variety of work the archaeological profession undertakes day-to-day across the globe, and helps to raise public awareness of the relevance and importance of archaeology to the modern world.
The first ever Day of Archaeology was held in 2011 and, since then, the project had thousands of archaeologists take part in the event, from those working in the field through to specialists working in laboratories and behind computers. The last Day of Archaeology was on Friday 28th July 2017.
GPU Programming Part 2: Advanced GPU Programming
Creators: name: Meinke, Jan
name: Herten, Andreas
name: Hrywniak, Markus
name: Kraus, Jiri
name: Haghighi Mood, Kaveh
Publisher: name: Forschungzentrum Jülich
Year: 2023

description: Lecture at JSC - as part of the Training Programme of Forschungszentrum Jülich (online, Germany), 19 Jun 2023 - 23 Jun 2023
description: GPU-accelerated computing drives current scientific research. Writing fast numeric algorithms for GPUs offers high application performance by offloading compute-intensive portions of the code to a GPU.The course covers aspects of GPU architectures and programming. Focus is on the usage of the parallel programming language CUDA C++, which allows maximum control of NVIDIA GPU hardware. Examples of increasing complexity are used to demonstrate optimization and tuning of scientific applications. The foundations of GPU programming are covered in another dedicated Basic Course.This advanced course consists of modules providing more in-depth coverage of multi-GPU programming, modern CUDA concepts, CUDA Fortran, and portable programming models such as OpenACC and C++ parallel STL algorithms.
Bits and piecing
Creators: name: Adams, Sophie
Publisher: name: Archaeology Data Service
Year: 2016

description: This resource is a single blog post created as part of the Day of Archaeology initiative. The Day of Archaeology project aimed to provide a window into the daily lives of archaeologists from all over the world. The project asked people working, studying or volunteering in the archaeological world to participate in a 'Day of Archaeology' each year by recording their day and sharing it through text, images or video on the Day of Archaeology blog.
The project asked anyone with a personal, professional or voluntary interest in archaeology to get involved, and help highlight the reasons why archaeology is vital to protect the past and inform our futures. The resulting Day of Archaeology project archive demonstrates the wide variety of work the archaeological profession undertakes day-to-day across the globe, and helps to raise public awareness of the relevance and importance of archaeology to the modern world.
The first ever Day of Archaeology was held in 2011 and, since then, the project had thousands of archaeologists take part in the event, from those working in the field through to specialists working in laboratories and behind computers. The last Day of Archaeology was on Friday 28th July 2017.
Additional file 2 of Implementation of a campus-based and peer-delivered HIV self-testing intervention to improve the uptake of HIV testing services among university students in Zimbabwe: the SAYS initiative
Creators: name: Mukora-Mutseyekwa, Fadzai
name: Mundagowa, Paddington Tinashe
name: Kangwende, Rugare Abigail
name: Murapa, Tsitsi
name: Tirivavi, Mandla
name: Mukuwapasi, Waraidzo
name: Tozivepi, Samantha Nokuthula
name: Uzande, Charles
name: Mutibura, Queen
name: Chadambuka, Elizabeth Marian
name: Machinga, Mazvita
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 2. Training Evaluation Form.
Additional file 9 of The tomato CONSTANS-LIKE protein SlCOL1 regulates fruit yield by repressing SFT gene expression
Creators: name: Cui, Long
name: Zheng, Fangyan
name: Wang, Jiafa
name: Zhang, Chunli
name: Zhang, Dedi
name: Gao, Sunan
name: Zhang, Chenhui
name: Ye, Jie
name: Zhang, Yuyang
name: Ouyang, Bo
name: Wang, Taotao
name: Hong, Zonglie
name: Ye, Zhibiao
name: Zhang, Junhong
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 9: Table S1. Sequences of primers used in this study.
Opportunistic Secrecy with a Strict Delay Constraint
Creators: name: Khalil, Karim
name: Koyluoglu, O. Ozan
name: Gamal, Hesham El
name: Youssef, Moustafa
Publisher: name: arXiv
Year: 2009
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: We investigate the delay limited secrecy capacity of the flat fading channel under two different assumptions on the available transmitter channel state information (CSI). The first scenario assumes perfect prior knowledge of both the main and eavesdropper channel gains. Here, upper and lower bounds on the delay limited secrecy capacity are derived, and shown to be tight in the high signal-to-noise ratio (SNR) regime. In the second scenario, only the main channel CSI is assumed to be available at the transmitter where, remarkably, we establish the achievability of a non-zero delay-limited secure rate, for a wide class of channel distributions, with a high probability. In the two cases, our achievability arguments are based on a novel two-stage key-sharing approach that overcomes the secrecy outage phenomenon observed in earlier works.
description: Submitted to IEEE Transactions on Information Theory
DRUG-CONJUGATES FOR SELF-ASSEMBLED NANOPARTICLES IN ANTICANCER TREATMENT
Creators: name: FUMAGALLI, GAIA
Publisher: name: Universit� degli Studi di Milano
Year: 2018

description: This dissertation is an overview on the functionalization of known anticancer compounds in order to form different drug-conjugates able to self-assemble in water to form nanoparticles. This approach is useful to improve the drug delivery properties and pharmacokinetic profile of anticancer drugs. All the described conjugates, except for the ones illustrated in chapter 5, have the same general structure: the anticancer drug is connected to the self-assembly inducer trough a linker. Chapter 1 regards a general introduction about nanomedicine, the advantages of the use of nanotechnology-based systems in cancer treatment and the benefits of nano- formulated drugs in the improvement of drug-delivery. Furthermore, nanoparticles are presented with a focus on their classification, characterization and preparation techniques. Chapter 2 regards the preparation of different types of self-assembled nanoparticles using various anticancer compounds and dyes but with the same lipophilic tail as self- assembling inducer: squalene. Different natural anticancer compounds such as paclitaxel, cyclopamine and doxorubicin and dyes, as fluorescein and tetramethylrhodamine, were functionalized to obtain squalene-based conjugates. Both hetero-nanoparticles composed by two drug-conjugates and drug- and dye-conjugates were prepared and tested. Chapter 3 is focused on the importance of the self-assembly inducer and describes the preparation of new conjugates containing an active moiety as self-assembly inducer. In particular, in this section, is described the preparation of conjugates composed by aloin or podophyllotoxin as active compounds and 4-(1,2-diphenylbut-1-en-1-yl) aniline, an analog of the know anticancer compound tamoxifen, as self-assembly inducer. Chapter 4 highlights the influence of the linker between the active compound and the self-assembly inducer to obtain an effective release of the free drug. In particular, it is described the synthesis of a new self-immolative linker able to trigger the drug release in particular conditions, specifically in the presence of a lipase. This linker was used for the preparation of two conjugates containing the known anticancer compound N- desacetylthiocolchicine. Chapter 5 concerns the preparation of dual drug-conjugates able to form nanoparticles without the presence of a self-assembly inducer. These conjugates have a symmetrical structure: two molecules of the same drug are linked by a chain able to guarantee the drug release in particular conditions. The natural anticancer compounds involved in the preparation of this type of conjugates are paclitaxel, epothilone A, podophyllotoxin and camptothecin and the linker used contain a disulfide moiety able to be cleaved in cellular environment.
No Man s Sky Archaeological Survey
Creators: name: Reinhard, Andrew
Publisher: name: Archaeology Data Service
Year: 2016

description: This resource is a single blog post created as part of the Day of Archaeology initiative. The Day of Archaeology project aimed to provide a window into the daily lives of archaeologists from all over the world. The project asked people working, studying or volunteering in the archaeological world to participate in a 'Day of Archaeology' each year by recording their day and sharing it through text, images or video on the Day of Archaeology blog.
The project asked anyone with a personal, professional or voluntary interest in archaeology to get involved, and help highlight the reasons why archaeology is vital to protect the past and inform our futures. The resulting Day of Archaeology project archive demonstrates the wide variety of work the archaeological profession undertakes day-to-day across the globe, and helps to raise public awareness of the relevance and importance of archaeology to the modern world.
The first ever Day of Archaeology was held in 2011 and, since then, the project had thousands of archaeologists take part in the event, from those working in the field through to specialists working in laboratories and behind computers. The last Day of Archaeology was on Friday 28th July 2017.
Scrambled Messages: 150 years of the Atlantic telegraph cable
Creators: name: Newland, Cassie
Publisher: name: Archaeology Data Service
Year: 2016

description: This resource is a single blog post created as part of the Day of Archaeology initiative. The Day of Archaeology project aimed to provide a window into the daily lives of archaeologists from all over the world. The project asked people working, studying or volunteering in the archaeological world to participate in a 'Day of Archaeology' each year by recording their day and sharing it through text, images or video on the Day of Archaeology blog.
The project asked anyone with a personal, professional or voluntary interest in archaeology to get involved, and help highlight the reasons why archaeology is vital to protect the past and inform our futures. The resulting Day of Archaeology project archive demonstrates the wide variety of work the archaeological profession undertakes day-to-day across the globe, and helps to raise public awareness of the relevance and importance of archaeology to the modern world.
The first ever Day of Archaeology was held in 2011 and, since then, the project had thousands of archaeologists take part in the event, from those working in the field through to specialists working in laboratories and behind computers. The last Day of Archaeology was on Friday 28th July 2017.
title: Public Opinion on Renewable Energy: The Nexus of Climate, Politics, and Economy
Creators: name: Olson-Hazboun, Shawn K.
Publisher: name: Utah State University
Year: 2017

description: Increased use of renewable energy sources in the generation of electricity is a crucial component of transitioning to a less polluting energy system in the United States. Technologies like solar photovoltaic cells and wind turbines are being deployed at a rapid rate around the country, which means that an increasing portion of the public is becoming aware of renewable energy systems. The construction of these new industrial facilities has resulted in a variety of public reactions, positive and negative. Citizen opposition has been widely observed toward a variety of renewable energy facilities, and citizen groups can influence policy-making at the national, state, and local levels. Further research is needed to understand under what circumstances the public may take oppositional stances.
To examine this topic, I analyze public perceptions of renewable energy using three different datasets. First, I used data from a survey conducted in 2014 in five communities in Utah, Wyoming, and Idaho experiencing renewable energy development(n=906). This dataset allowed me to untangle what factors help explain both individual as well as community-level variation in support for renewable energy. Second, I employed nationally representative survey data (n=13, 322)collected from 2008 to 2015 to examine the influence of a number of factors hypothesized to shape individuals’ level of support for renewable energy policies including socio-demographic characteristics, political beliefs, belief in anthropogenic climate change, and nearby extractive industry activities. Last, I analyzed discourse about renewable energy in sixty-one semi-structured interviews with individuals representing various community sectors in three energy-producing rural communities in Utah.
My research findings, on a whole, suggest that several place-based factors are significant in shaping public opinion about renewable energy, including community experience with renewable energy and local economic reliance on extractive industries. I also find pervasive climate skepticism across study sites. These findings indicate the need for broad-based and non-partisan discursive frames for renewable energy. Last, these findings speak to the importance of the ‘just transitions’ concepts, and the need to incorporate those communities most marginalized by the current system of fossil fuels extraction and production as society moves forward toward a cleaner energy economy.
Fouling of heated stainless steel tubes with ferric oxide from flowing water suspensions
Creators: name: Hopkins, Robert Montgomery
Publisher: name: University of British Columbia
Year: 2011

description: The fouling behaviour of ferric oxide (hematite) particles suspended in water flowing through 0.343 inch i.d. type 304 stainless steel tubes was experimentally investigated. Independent variables studied, using micron and submicron size particles, were ferric oxide concentration (15 - 3750 ppm), tube Reynolds No. (10090 - 37590) and heat flux (0 - 92460 BTU/ft²-hr). For selected runs, fouled tubes were sectioned and the fouling deposit subjected to "in situ" chemical analysis by means of an electron microprobe. During the fouling process, measurements were made of local and average thermal resistance as a function of time. The resulting fouling curves fell into three distinct categories, depending on the particle concentration and the mode of operation: (I) At ferric oxide concentrations below 100 ppm, no thermal fouling could be detected over experimental periods of up to 14 days. Microprobe examination of such tubes showed spotty deposits. (2) At ferric oxide concentrations of. 750 ppm and higher, using mixed size particles, measurable thermal fouling occurred at a steadily decreasing rate, similar to the asymptotic type behaviour reported previously in other fouling systems. In the present study, the asymptotic condition was achieved after about four hours of operation. Prolonged operation resulted in a sudden decrease in fouling resistance at localized positions on the test section, followed by refouling of the whole test section. (3) If the suspension was circulated through the test section at zero heat flux for approximately eight hours and then heating started, the tube commenced fouling thermally at a constant rate considerably greater than the previous decreasing rates. Microprobe results showed the deposits to contain, in addition to iron and oxygen, significant amounts of nickel and chromium. Chemical composition profiles typically showed nickel and chromium concentration gradients from the wall inwards, concentrations varying from the highest values at the wall to zero at the deposit-fluid interface. A test section used for a series of fouling trials, when examined under an electron microscope, was found to contain small but distinct pits. A hypothesis is presented according to which the fouling behaviour of water suspended ferric oxide on stainless steel is controlled by the rate at which crevice corrosion of the stainless steel occurs. The corrosion products precipitate within the initially loose deposit structure and thus serve to stabilize this structure. The corrosion rate is in turn controlled by the oxygen reduction rate at unfouled areas on the tube wall. Experiments specifically designed to test this hypothesis, such as increasing the unfouled area in an attempt to accelerate the corrosion rate, and removing oxygen with a scavenger in order to decrease the rate, gave results entirely consistent with the hypothesis. Mathematical models based on the hypothesis are explored.
title: A Validity Study: Relationship Between the Self Inventory Scale, the California Psychological Inventory, and the Adjective Check List
Creators: name: Newbold, David
Publisher: name: Utah State University
Year: 1978

description: The specific objective of this research was to begin assessment of construct validity of the Self Inventory Scale.
Subjects were 100 Utah State University students, living in university dormitories, chosen at random.
Subjects were administered the Self Inventory Scale and the California Psychological Inventory. Subjects submitted names of peers, one of whom was asked to complete an Adjective Check List describing the subject.
CPI subscale scores were correlated with Self Inventory Scale subscale scores, to determine the relationship between underlying constructs. Sixty-four of the 126 correlations computed were significant at the .01 significance level. Similarity of construct and configurational analysis of significant correlations suggest construct validity exists for Self Inventory Scale subscales.
Contract Archaeologists go back to school
Creators: name: Chíobháin Enqvist, Delia Ní
Publisher: name: Archaeology Data Service
Year: 2016

description: This resource is a single blog post created as part of the Day of Archaeology initiative. The Day of Archaeology project aimed to provide a window into the daily lives of archaeologists from all over the world. The project asked people working, studying or volunteering in the archaeological world to participate in a 'Day of Archaeology' each year by recording their day and sharing it through text, images or video on the Day of Archaeology blog.
The project asked anyone with a personal, professional or voluntary interest in archaeology to get involved, and help highlight the reasons why archaeology is vital to protect the past and inform our futures. The resulting Day of Archaeology project archive demonstrates the wide variety of work the archaeological profession undertakes day-to-day across the globe, and helps to raise public awareness of the relevance and importance of archaeology to the modern world.
The first ever Day of Archaeology was held in 2011 and, since then, the project had thousands of archaeologists take part in the event, from those working in the field through to specialists working in laboratories and behind computers. The last Day of Archaeology was on Friday 28th July 2017.
Additional file 1 of Terminology and descriptions of navigation and related practices for children with neurodisability and their families: a scoping review
Creators: name: Gardiner, Emily
name: Wong, Vivian
name: Lin, Grace
name: Miller, Anton R.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 1.
Archaeology and the smell of history
Creators: name: Guermandi, Maria Pia
Publisher: name: Archaeology Data Service
Year: 2016

description: This resource is a single blog post created as part of the Day of Archaeology initiative. The Day of Archaeology project aimed to provide a window into the daily lives of archaeologists from all over the world. The project asked people working, studying or volunteering in the archaeological world to participate in a 'Day of Archaeology' each year by recording their day and sharing it through text, images or video on the Day of Archaeology blog.
The project asked anyone with a personal, professional or voluntary interest in archaeology to get involved, and help highlight the reasons why archaeology is vital to protect the past and inform our futures. The resulting Day of Archaeology project archive demonstrates the wide variety of work the archaeological profession undertakes day-to-day across the globe, and helps to raise public awareness of the relevance and importance of archaeology to the modern world.
The first ever Day of Archaeology was held in 2011 and, since then, the project had thousands of archaeologists take part in the event, from those working in the field through to specialists working in laboratories and behind computers. The last Day of Archaeology was on Friday 28th July 2017.
THE DUAL ROLE OF YAP IN DRIVING TGF�-MEDIATED ENDMT
Creators: name: SAVORANI, CECILIA
Publisher: name: Universit� degli Studi di Milano
Year: 2018

description: Endothelial-to-mesenchymal transition (EndMT) is a biological process that allows the transdifferentiation of endothelial cells into mesenchymal cells, thus originating cells capable of novel functions necessary for the surrounding environment. EndMT regulates endocardial cushion formation during embryo development, and it is stimulated by the TGF?/BMP family of ligands. In adults, EndMT is activated upon an injury event or during pathological conditions like organ fibrosis, cerebral cavernous malformation, cancer-associated fibroblast generation, and others. Hence, it is necessary to better characterize the molecular regulators cooperating with TGF? signaling in driving EndMT, to possibly provide novel therapeutic targets to treat these pathological conditions. Here we studied YAP, a co-transcriptional regulator involved in several cell biology processes, among which epithelial-to-mesenchymal transition (EMT). Since EndMT is considered a ?specialized? form of EMT, and since YAP and TGF? signaling were shown to cross-talk in other contexts, we hypothesized that YAP contributes to EndMT by modulating TGF? signaling, and characterized the underlying molecular mechanism. Results here presented demonstrate that YAP is required for a complete TGF?-mediated EndMT response in vitro, and that YAP contributes specifically to SMAD3-, but not SMAD1-, driven EndMT gene transcription. We provide novel evidence that YAP positively regulates EndMT playing the twofold role of acting as SMAD3 co-transcriptional factor on the promoter of EndMT target genes and, in parallel, preventing SMAD3 from degradation. YAP is therefore emerging as a possible candidate target to inhibit pathological TGF?-driven EndMT.
Standard Quantum Limit for Probing Mechanical Energy Quantization
Creators: name: Miao, Haixing
name: Danilishin, Stefan
name: Corbitt, Thomas
name: Chen, Yanbei
Publisher: name: arXiv
Year: 2009
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We derive a standard quantum limit for probing mechanical energy quantization in a class of systems with mechanical modes parametrically coupled to external degrees of freedom. To resolve a single mechanical quantum, it requires a strong-coupling regime -- the decay rate of external degrees of freedom is smaller than the parametric coupling rate. In the case for cavity-assisted optomechanical systems, e.g. the one proposed by Thompson et al., zero-point motion of the mechanical oscillator needs to be comparable to linear dynamical range of the optical system which is characterized by the optical wavelength divided by the cavity finesse.
description: 4 pages, 2 figures. Accepted by Phys. Rev. Lett