cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
"The Swirling Sphere Has Opened": Pound in Paradise
Creators: name: Bradley Sadowsky
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description: An exploration of the theme of paradise in Ezra Pound's corpus. This paper tackles the aesthetics, metaphysics, and political implications of Pound's paradise, as well as his reception of mystic Neoplatonic thought. Bradley Sadowsky's (2024) senior thesis in the Department of English and Comparative Literature, supervised by Dr. David Ross.
title: Medallas de las Colonias... de Espana Texte imprimé
Creators: name: Florez, Henrique
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: 3 vol. : portr. pl. ; in-4
description: Source: Bibliothèque patrimoniale Villon (Rouen), fonds Liber, Mtm-20520
description: Coverage: 1757-1773
Comparing Provincial Carbon Emission Regulation Policies in Canada: Impacts on Greenhouse Gas Emissions, Production, and Labor Measures
Creators: name: Maladkar, Pallavi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024
Subjects: Carbon taxes--Econometric models

description: Carbon emissions regulation policies have been instituted in several countries and sub-national regions within the last 35 years to force firms to reduce emissions. However, these policies have been accused of reducing economic growth. This research utilizes a difference-in-differences model with two-way fixed effects to explore how carbon taxes, credit systems, and cap-and-trade systems instituted across 13 Canadian provinces from 2004-2022 impact emissions and economic outcomes (GDP, employment, hours worked, and earnings). Estimates demonstrate that, in general, none of the policies lower emissions at significant levels or hurt the economy overall. Carbon taxes have slight negative effects on GDP and earnings. Cap-and-trade systems have no effects on economic outcomes. Extending the model shows that the policies effectively target the highest-emitting economic sectors and the most emission-intensive industries. Cap-and-trade systems are more effective at accomplishing this than carbon taxes while also allowing for economic growth in less emission-intensive industries and reducing emissions directly rather than through decreased economic activity.
title: OFROM: interview avec unine11c11m
Creators: name: Delafontaine, François
name: Claivaz, Amélie
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.14cd9l7n.v2#f78c583323d3f346430607f25ca222ab41ea6b70
Supplementary Figure 3 from SBE6: a novel long-range enhancer involved in driving sonic hedgehog expression in neural progenitor cells
Creators: name: Benabdallah, Nezha S.
name: Gautier, Philippe
name: Betul Hekimoglu-Balkan
name: Lettice, Laura A.
name: Shipra Bhatia
name: Bickmore, Wendy A.
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Developmental Biology
subject: 60408 Genomics
subject: FOS: Biological sciences

description: The expression of genes with key roles in development is under very tight spatial and temporal control, mediated by enhancers. A classic example of this is the sonic hedgehog gene (Shh) that plays a pivotal role in the proliferation, differentiation and survival of neural progenitor cells both in vivo and in vitro. Shh expression in the brain is tightly controlled by several known enhancers that have been identified through genetic, genomic and functional assays. Using chromatin profiling during the differentiation of embryonic stem cells to neural progenitor cells, here we report the identification of a novel long-range enhancer for Shh-Shh-brain-enhancer-6 (SBE6) that is located 100 kb upstream of Shh and that is required for the proper induction of Shh expression during this differentiation programme. This element is capable of driving expression in the vertebrate brain. Our study illustrates how a chromatin-focused approach, coupled to in vivo testing, can be used to identify new cell-type specific cis-regulatory elements and points to yet further complexity in the control of Shh expression during embryonic brain development.
Health or Satisfaction? Investigating the Link Between Patient Satisfaction Scores and Provider Prescribing Patterns
Creators: name: Farrag, Omar
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description: In 2006, the Centers of Medicare and Medicaid Services (CMS) introduced the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS), which were made public quarterly beginning in 2008 and are based on subjective measures of patient satisfaction. We suspect these scores create additional incentives driving inefficient prescribing patterns. Using ambulatory and out-patient facilities in the State of New York in conjunction with HCAHPS scores, we test our hypothesis that patient satisfaction scores induce inefficient prescribing behavior. We find hospital systems’ preferences for raising scores in the prescribing setting is not monotonic, with a 1-standard-deviation increase in the present year’s satisfaction score triggering a 4.16 percentage point increase in the likelihood of prescribing to a patient whom we do not expect to present a case commonly susceptible to overprescribing. Additionally, we find that the prescribing behavior of public hospitals is not as influenced by changes in their satisfaction scores as is the prescribing behavior of private hospitals. Finally, we investigate prescribing treatment towards subgroups of the patient population and find that women, racial minorities, and self-paying patients are the most vulnerable to experiencing differential treatment and inefficient prescribing patterns in response to changes in satisfaction scores.
The Effects of Adolescent Depression and ADHD on Educational Attainment in Adulthood
Creators: name: Chen, Jiaqi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description: Mental disorders, notably early-onset depression and ADHD are of increasing concern for U.S. adolescents. Past research provides inconclusive findings on the effects of adolescent depression and ADHD on educational attainment, and the mechanisms for such effects are unclear. In this paper, I estimate the causal effects of adolescent depression and ADHD on adulthood educational attainment using data from the National Longitudinal Study of Adolescent to Adult Health. To tackle unobservable confounders, measurement errors, and reverse causality, I use polygenetic scores (PGSs), friend suicide attempts, and the interview period as instruments for depression and ADHD. I find that a one standard deviation increase in adolescent ADHD score reduces years of education by 1.5-1.6, the predicted probability of attaining some post-secondary education by 15.2-16.5 percentage points, and the predicted probability of achieving a bachelor’s degree by 26.5-26.6 percentage points. Early-onset depression does not have significant effects on educational attainment. I further uncover that the adverse effects of ADHD on education arise through mechanisms of impaired cognitive and non-cognitive skills using intermediate in-school performance and educational outcomes. Potential interventions to mitigate the negative effects of ADHD could be school-based interventions and parent management training.
A COEXISTÊNCIA ENTRE O TRÁFICO DE DROGAS E O CRIME ORGANIZADO NO BRASIL: UM ESTUDO DOS IMPACTOS NOS ÂMBITOS FAMILIAR E SOCIAL
Creators: name: Bruna Vitoria Sousa COSTA
name: Gabriela Correia de ALMEIDA
name: Jocirley de OLIVEIRA
Publisher: name: Zenodo
Year: 2024
Subjects: Tráfico de Drogas
Crime Organizado
Violência Social
Impacto Familiar
Políticas Públicas

description: RESUMO

O presente artigo tem como objetivo analisar a coexistência entre o tráfico de drogas e o crime organizado no Brasil, com foco nos impactos que essa relação exerce nos âmbitos familiar e social. O tráfico de drogas, profundamente enraizado no contexto das organizações criminosas, desempenha um papel central na dinâmica de violência, exclusão social e desestruturação familiar, agravando os problemas sociais existentes e criando desafios para a sociedade brasileira. A pesquisa, de natureza qualitativa e baseada em revisão bibliográfica, explora a literatura existente para identificar e compreender as múltiplas formas como o crime organizado se entrelaça com o tráfico de drogas, examinando as consequências diretas e indiretas dessa relação para as famílias afetadas e para a sociedade como um todo. Os resultados indicam que a interação entre essas duas formas de criminalidade contribui para a intensificação da violência nas comunidades, a desagregação familiar e a perpetuação de ciclos de pobreza e exclusão social. Além disso, os dados sugerem que as políticas públicas voltadas para o combate ao tráfico de drogas e ao crime organizado carecem de maior integração e foco na mitigação dos efeitos sociais, especialmente no que tange à proteção e ao apoio às famílias diretamente impactadas.
Measuring Care Coordination for High Need Children: Structure and Process from EPIC Notes
Creators: name: Catherine Allen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description: Introduction: Children with medical complexity (CMC), intellectual and developmental disorders (IDD), and psychiatric conditions are a unique pediatric population that requires complex care coordination to enhance care outcomes. Care coordination while beneficial, is often difficult to implement in practice due to billing issues and lack of resources. This study aims to capture the structure and process of billed care coordination in a sample of children with medical complexity from the medical record.
Methods: This project utilized a qualitative retrospective study design to capture the structure and process of billed care coordination. Billed medical notes involving care coordination in high need children age 17 or younger with 1 or 2 complex chronic conditions seen annually from 2015-2019 at UNC health systems were extracted from the EPIC system (N=15). A literature review was completed to create a codebook of important aspects of care coordination related to structure and process, medical notes were then coded for features of care coordination. Notable quotes and themes were extrapolated to detail the process of care coordination.
Results: Two types of encounters were identified from the medical notes; post hospitalization care management and monthly care coordination visits which displayed differing structures involving billing codes, time spent, and mode of communication. The inclusion of prepopulated text in these notes limited the amount of detail that was available relating to the care coordination visit. Themes identified relating to process included prepopulated notes, legal work, barriers to care, vaccines, mental health, and medical specialists. These notes typically offered a brief list of items accomplished during a visit and a list of items that still need attention. 
Conclusions: This is one of the first studies to gain an accurate picture of care coordination as it is occurring in clinical practice. This study showcases the importance of billed care coordination in practice and the benefits it can provide to children with medical complexity. Future research is needed evaluating care coordination to gain a wider view of care coordination practices; particularly studies that include unbilled care coordination or other vulnerable populations.
Building the rationale for a national immunization registry in the U.S.
Creators: name: Lin, Sendy
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description: Current immunization information systems (IIS) in the United States (US) contribute to fragmented and poorly accessible documentation systems at the state and local level, where immunization records are often incomplete, inconsistent, and inaccessible beyond state borders. With patients seeking care from multiple providers and relocating across states, the system hinders public health initiatives to improve vaccination rates, decrease vaccine-preventable diseases, and identify high-risk populations to target resources. This study examines current barriers to a national immunization registry in the US through interviews with experts in healthcare, policy, and health economics fields. This project employed structured in-depth interviews to answer why a national immunization registry has not materialized in the US, what potential barriers exist to creating and implementing a national immunization database, and what the potential benefits may be. Snowball sampling was used to recruit and interview 29 key informants across different roles (healthcare practitioners n=3, industry n=5, government n=4, international/non-governmental organizations n=6, and academia n=11) and across areas of expertise (e.g. policy, economics, public health, health information systems, patient care). Interviews were transcribed and coded, and common themes were extracted and analyzed. Most respondents (n=26, 90%) were in support of a national registry but only 10% (n=3) believed in its feasibility in the US.  Nearly a third believed that it is extremely difficult to implement (n=9, 31%), while others were ambivalent (n=17, 59%). Reported barriers for a national immunization registry included patient concern for privacy of data, political opposition, distrust in vaccines and/or government, administrative burden to providers/clinics, cost of implementation/development, and resistance from states to implement a national system. However, two-thirds of the respondents (n=13, 76%) believed that the COVID-19 pandemic had had a positive impact on their perspective towards a national immunization registry. Perceived benefits included the ability to assess up-to-date coverage nationwide, identify under-immunized populations, improve the continuity of records, optimize vaccine inventory management, monitor adverse events, improve efficiencies, and prevent disease outbreaks. Advancements in data sharing standards have made it easier to consolidate existing state-level immunization registries towards having a unified national system in the US. Despite the challenges, the COVID-19 pandemic has raised the profile of the benefits of a national registry, making it opportune to re-evaluate US policies towards a national immunization registry.
Chinese Import Competition and Dampened Monetary Policy in the US Counties
Creators: name: Decker, Thomas
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description: The long decline in US manufacturing related to the emergence of China as a global economic superpower
has been studied in myriad contexts, but whether it has dampened the effectiveness of US monetary
policy remains unclear. As such a manufacturing loss would erode the interest rate channel of monetary
policy transmission, there is good reason to believe that this is the case. Using local projections, this
research finds a strong effect of Chinese import penetration in US counties from 1992-2008 on reducing
monetary shock troughs. This finding is robust to a host of county level demographic and economic controls,
as well as alternative shock series. The effect of import penetration at higher deciles is positive,
increasing, and significant across employment, wage, and establishment responses. Further analysis finds
the same relationship using data for 2008-2022. These results are important for policymakers inside and
outside of the central bank, especially considering recent persistent inflation.
Modeling Demand, Substitution, and Pricing in the Transition from Cable TV to Streaming
Creators: name: Constantine, Cody
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description: Consumer choice in television media has expanded to include a range of internet-based streaming services, alternatives to expensive but all-inclusive cable TV bundles. This change has revitalized the debate regarding "a la carte" provision of cable channels in a new context, as streaming platforms now offer bundles of linear content that were once exclusive to cable packages. A 2017-2018 data set on household-level internet usage, TV usage, and billing for a North American multiple-system operator (MSO) is used to estimate a model of consumer demand as it relates to genres of content within a cable TV bundle as well as the over-the-top streaming service alternatives. A counterfactual simulation is used to estimate optimal pricing and demand for genre-based "a la carte" streaming services as competitors with the traditional cable bundle. The optimal pricing for genre-based "a la carte" services is found to be between 7.6 - 45.8% of the original cable bundle price, and the mean projected change in MSO profit is -4.24%.
Modifying and Applying Hotelling’s Model to the Short-Term Rental Market
Creators: name: Berkowitch, Evan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description: Standard spatial competition models do not consider an agglomeration effect, a 
consumer’s preference for competing firms to locate near each other. I modify the 
canonical Hotelling model by adding an agglomeration force and considering quadratic 
transportation costs. This agglomeration effect posits that consumers derive more utility 
when firms are located close together. I derive the optimal distance between firms 
depending on the strength of the agglomeration force relative to the transportation costs. 
Through data on Airbnb listings, points of wedding venues and transit stops, I develop a 
regression model to approximate the pairwise firm distance in Boston and San Francisco. 
I find that Boston’s Airbnb listings follow the prediction of the modified Hotelling Model 
while San Francisco’s do not exhibit evidence of an agglomeration force. Based on the 
interaction terms, I find a higher relative strength of the agglomeration effect compared to 
transportation cost.
Does Female Management Make a Difference? An Empirical Analysis of Gender Wage Gap in Business Sector
Creators: name: Peng, Yiwen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description: This research investigates the effect of female leadership representation on gender equality in terms of wages in the corporate sector. It specifically examines the influence of female CEO share on the gender wage gap across various industries. Utilizing data from Executive Composition, Annual Fundamentals, and Current Population Survey, this research employs empirical analysis to examine the directions and levels of influence from female leaders. After implementing baseline OLS, joint estimation, mediating sequential model, and instrumental variables, this research finds that an augmented presence of female CEOs in the corporate sphere will bring more gender equality in terms of labor wages and executive compensations.
title: An epigenetic switch links stromal pyruvate dehydrogenase activation to extracellular matrix production via proline synthesis
Creators: name: Kay, Emily
Publisher: name: University of Glasgow
Year: 2020

description: Cancer associated fibroblasts (CAFs) are known to influence tumour progression through the secretion of factors which influence tumour growth and invasion. Collagen production is a major aspect of the secretory CAF phenotype. High collagen content in breast cancer is a marker of poor prognosis and is known to promote tumour growth and metastasis, as well is impeding drug delivery to the tumour through reduced perfusion. Tumour metabolism is also well established as a hallmark of cancer, however, how the metabolism of CAFs influences their pro-tumourigenic phenotype is not yet well understood. We investigated metabolic differences between paired CAFs and normal fibroblasts (NFs) from breast tissue. Using an unbiased phosphoproteomic analysis, we identified pyruvate dehydrogenase kinase 2 (PDK2) as the most downregulated kinase in CAFs. PDK2 phosphorylates and deactivates pyruvate dehydrogenase (PDH), which is a key metabolic protein that converts pyruvate to acetyl-CoA in the mitochondria, providing a key link between the major metabolic pathways of glycolysis and the TCA cycle. However, extensive metabolic profiling of CAFs and NFs did not reveal metabolic differences that could be attributed to PDH activity. Acetyl-CoA is also used for protein acetylation, and, using an MS-proteomic approach, we discovered increased histone acetylation in CAFs, which has epigenetic implications for how CAFs regulate their activated phenotype. Using a combination of proteomics, metabolomics, in vitro assays and imaging analyses we investigated the role of PDH-mediated histone acetylation in CAFs and uncovered the importance of histone acetylation in regulating collagen and ECM production by CAFs. PDH activity also regulated PYCR1 expression in CAFs, and we further discovered that proline production by PYCR1 is further required to maintain PDH-activity induced collagen synthesis in CAFs. Our findings open up new possibilities for targeting the desmoplastic stroma to reduce tumour growth and metastasis, and improve drug delivery.
Carnet nº 16, commencé à Hankou (p. 3)
Creators: name: Péraire, Lucien
name: CNRS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023

description: created: 4-12-1930
Supplementary Figure 1 from SBE6: a novel long-range enhancer involved in driving sonic hedgehog expression in neural progenitor cells
Creators: name: Benabdallah, Nezha S.
name: Gautier, Philippe
name: Betul Hekimoglu-Balkan
name: Lettice, Laura A.
name: Shipra Bhatia
name: Bickmore, Wendy A.
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Developmental Biology
subject: 60408 Genomics
subject: FOS: Biological sciences

description: The expression of genes with key roles in development is under very tight spatial and temporal control, mediated by enhancers. A classic example of this is the sonic hedgehog gene (Shh) that plays a pivotal role in the proliferation, differentiation and survival of neural progenitor cells both in vivo and in vitro. Shh expression in the brain is tightly controlled by several known enhancers that have been identified through genetic, genomic and functional assays. Using chromatin profiling during the differentiation of embryonic stem cells to neural progenitor cells, here we report the identification of a novel long-range enhancer for Shh-Shh-brain-enhancer-6 (SBE6) that is located 100 kb upstream of Shh and that is required for the proper induction of Shh expression during this differentiation programme. This element is capable of driving expression in the vertebrate brain. Our study illustrates how a chromatin-focused approach, coupled to in vivo testing, can be used to identify new cell-type specific cis-regulatory elements and points to yet further complexity in the control of Shh expression during embryonic brain development.
title: OFROM: interview avec unine11c10m
Creators: name: Delafontaine, François
name: Claivaz, Amélie
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.066006dm.v2#43d447578a4c7a6f659f7e7a2ef3a7d48879a5e2
Supplementary Table 3 from SBE6: a novel long-range enhancer involved in driving sonic hedgehog expression in neural progenitor cells
Creators: name: Benabdallah, Nezha S.
name: Gautier, Philippe
name: Betul Hekimoglu-Balkan
name: Lettice, Laura A.
name: Shipra Bhatia
name: Bickmore, Wendy A.
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Developmental Biology
subject: 60408 Genomics
subject: FOS: Biological sciences

description: The expression of genes with key roles in development is under very tight spatial and temporal control, mediated by enhancers. A classic example of this is the sonic hedgehog gene (Shh) that plays a pivotal role in the proliferation, differentiation and survival of neural progenitor cells both in vivo and in vitro. Shh expression in the brain is tightly controlled by several known enhancers that have been identified through genetic, genomic and functional assays. Using chromatin profiling during the differentiation of embryonic stem cells to neural progenitor cells, here we report the identification of a novel long-range enhancer for Shh-Shh-brain-enhancer-6 (SBE6) that is located 100 kb upstream of Shh and that is required for the proper induction of Shh expression during this differentiation programme. This element is capable of driving expression in the vertebrate brain. Our study illustrates how a chromatin-focused approach, coupled to in vivo testing, can be used to identify new cell-type specific cis-regulatory elements and points to yet further complexity in the control of Shh expression during embryonic brain development.
Supplementary Table 2 from SBE6: a novel long-range enhancer involved in driving sonic hedgehog expression in neural progenitor cells
Creators: name: Benabdallah, Nezha S.
name: Gautier, Philippe
name: Betul Hekimoglu-Balkan
name: Lettice, Laura A.
name: Shipra Bhatia
name: Bickmore, Wendy A.
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Developmental Biology
subject: 60408 Genomics
subject: FOS: Biological sciences

description: The expression of genes with key roles in development is under very tight spatial and temporal control, mediated by enhancers. A classic example of this is the sonic hedgehog gene (Shh) that plays a pivotal role in the proliferation, differentiation and survival of neural progenitor cells both in vivo and in vitro. Shh expression in the brain is tightly controlled by several known enhancers that have been identified through genetic, genomic and functional assays. Using chromatin profiling during the differentiation of embryonic stem cells to neural progenitor cells, here we report the identification of a novel long-range enhancer for Shh-Shh-brain-enhancer-6 (SBE6) that is located 100 kb upstream of Shh and that is required for the proper induction of Shh expression during this differentiation programme. This element is capable of driving expression in the vertebrate brain. Our study illustrates how a chromatin-focused approach, coupled to in vivo testing, can be used to identify new cell-type specific cis-regulatory elements and points to yet further complexity in the control of Shh expression during embryonic brain development.
Supplementary Table 1 from SBE6: a novel long-range enhancer involved in driving sonic hedgehog expression in neural progenitor cells
Creators: name: Benabdallah, Nezha S.
name: Gautier, Philippe
name: Betul Hekimoglu-Balkan
name: Lettice, Laura A.
name: Shipra Bhatia
name: Bickmore, Wendy A.
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Developmental Biology
subject: 60408 Genomics
subject: FOS: Biological sciences

description: The expression of genes with key roles in development is under very tight spatial and temporal control, mediated by enhancers. A classic example of this is the sonic hedgehog gene (Shh) that plays a pivotal role in the proliferation, differentiation and survival of neural progenitor cells both in vivo and in vitro. Shh expression in the brain is tightly controlled by several known enhancers that have been identified through genetic, genomic and functional assays. Using chromatin profiling during the differentiation of embryonic stem cells to neural progenitor cells, here we report the identification of a novel long-range enhancer for Shh-Shh-brain-enhancer-6 (SBE6) that is located 100 kb upstream of Shh and that is required for the proper induction of Shh expression during this differentiation programme. This element is capable of driving expression in the vertebrate brain. Our study illustrates how a chromatin-focused approach, coupled to in vivo testing, can be used to identify new cell-type specific cis-regulatory elements and points to yet further complexity in the control of Shh expression during embryonic brain development.
RT-PCR cycle threshold value in combination with visual scoring of chest computed tomography at hospital admission predicts outcome in COVID-19
Creators: name: Ingberg, Edvin
name: Ahlstrand, Erik
name: Cajander, Per
name: Löf, Erika
name: Sundqvist, Martin
name: Wegener, Matthias
name: Lidén, Mats
name: Cajander, Sara
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: COVID-19 has a most variable prognosis. Several risk factors for an unfavourable outcome have been identified including extensive lung involvement on chest CT and high viral load estimated by RT-PCR cycle threshold (Ct) values. We investigated Ct value for outcome prediction, relation between Ct value and extent of lung involvement on chest CT and the combination of Ct value and chest CT lung involvement to predict outcome in COVID-19. Population-based retrospective study on all patients (n = 286) hospitalised for COVID-19 in Örebro Region, Sweden, between 1 March and 31 August 2020. Nasopharyngeal samples and chest CT at hospital admission were evaluated in relation to outcome of COVID-19. Both Ct value and chest CT lung involvement were independently associated with risk for ICU admission or death. Lung involvement was superior as a single parameter, but addition of Ct value increased the prediction performance. Ct value was especially useful to identify patients with high risk for severe disease despite limited lung involvement. The addition of RT-PCR Ct value to the assessment of lung involvement on chest CT adds valuable prognostic information in COVID-19. We believe that this information can be used to support clinical decision-making when managing COVID-19 patients.
Antibiotics duration guided by biomarkers in hospitalized adult patients; a systematic review and meta-analysis
Creators: name: Elnajdy, Dina
name: El-Dahiyat, Faris
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The impact of using biomarkers to determine the duration of antibiotics therapy has been studied. However, the question remains in clinical practice whether these biomarkers are reliable to determine antibiotics duration. This study is aimed to see if employing c-reactive protein (CRP) and Procalcitonin (PCT) to determine the duration of antibiotic use in hospitalized adult patients is both effective and safe. Search databases that were used are Pubmed, Cochrane library, and Embase. Only randomized controlled trials conducted in adult (≥18 years) hospitalized patients were included. The primary outcome assessed is the duration of antibiotics used. Secondary outcomes assessed are the length of hospitalization, recurrence of infection/rehospitalization, in-hospital mortality, and 28-day mortality. For the primary outcome, which is the duration of antibiotics use, PCT guided therapy significantly decreased the duration of antibiotics used in both sepsis and respiratory tract infections. For the secondary outcomes, there was no statistically significant difference in the outcomes of length of hospitalization, recurrence of infection/rehospitalization, and 28-day mortality. However, in-hospital mortality was significantly reduced (p = .02). CRP guided reduced antibiotic use duration, but there was no statistically significant difference in other outcomes including length of hospital stay, 28-day mortality, and infection recurrence. Procalcitonin-guided antibiotics therapy was shown to be effective and safe in the reduction of antibiotics duration in both sepsis and respiratory tract infections. More research is needed to prove that CRP-guided therapy is safe and effective to determine the antibiotic duration in adult hospitalized patients. PROSPERO (CRD42021264167).
Incidence of SARS-CoV-2 infection in a cohort of workers from the University of Porto, Portugal
Creators: name: da Costa, Joana Pinto
name: Meireles, Paula
name: Rodrigues, Pedro N. S.
name: Barros, Henrique
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Repeated serosurveys in the same population provide more accurate estimates of the frequency of SARS-CoV-2 infection and more comparable data over time than notified cases. We aimed to estimate the incidence of SARS-CoV-2 infection, identify associated factors, and assess time trends in the ratio of serological/molecular diagnosis in a cohort of university workers. Participants had a serological rapid test for SARS-CoV-2 immunoglobulins M and G, and completed a questionnaire, in May–July 2020 (n = 3628) and November 2020–January 2021 (n = 2661); 1960 participated in both evaluations and provided data to compute the incidence proportion and the incidence rate. Crude and adjusted incidence rate ratios (aIRR) and 95% confidence intervals (CI) were computed using generalized linear models with Poisson regression. The incidence rate was 1.8/100 person–months (95% CI: 1.5–2.0), and the 6 months’ cumulative incidence was 10.7%. The serological/molecular diagnosis ratio was 10:1 in the first evaluation and 3:1 in the second. Considering newly identified seropositive cases at the first (n = 69) and second evaluation (n = 202), 29.0% and 9.4% never reported symptoms, respectively, 14.5% and 33.3% reported contact with a confirmed case and 82.6%, and 46.0% never had a molecular test. Males (aIRR: 0.61; 95% CI: 0.44–0.85) and ‘high-skilled white-collar’ workers (aIRR: 0.74, 95% CI: 0.53–1.04) had lower risk of infection. University workers presented a high SARS-CoV-2 incidence while restrictive measures were in place. The time decrease in the proportion of undiagnosed cases reflected the increased access and awareness to testing, but opportunities continued to be missed, even in the presence of COVID-19-like symptoms.
Supplementary Figure 2 from SBE6: a novel long-range enhancer involved in driving sonic hedgehog expression in neural progenitor cells
Creators: name: Benabdallah, Nezha S.
name: Gautier, Philippe
name: Betul Hekimoglu-Balkan
name: Lettice, Laura A.
name: Shipra Bhatia
name: Bickmore, Wendy A.
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Developmental Biology
subject: 60408 Genomics
subject: FOS: Biological sciences

description: The expression of genes with key roles in development is under very tight spatial and temporal control, mediated by enhancers. A classic example of this is the sonic hedgehog gene (Shh) that plays a pivotal role in the proliferation, differentiation and survival of neural progenitor cells both in vivo and in vitro. Shh expression in the brain is tightly controlled by several known enhancers that have been identified through genetic, genomic and functional assays. Using chromatin profiling during the differentiation of embryonic stem cells to neural progenitor cells, here we report the identification of a novel long-range enhancer for Shh-Shh-brain-enhancer-6 (SBE6) that is located 100 kb upstream of Shh and that is required for the proper induction of Shh expression during this differentiation programme. This element is capable of driving expression in the vertebrate brain. Our study illustrates how a chromatin-focused approach, coupled to in vivo testing, can be used to identify new cell-type specific cis-regulatory elements and points to yet further complexity in the control of Shh expression during embryonic brain development.
MPEC 2024-E17 : 2024 CK11
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 CK11

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Successful treatment with a short course of remdesivir in a case of prolonged COVID-19 in a lymphoma patient
Creators: name: Kajova, Mikael
name: Kekäläinen, Eliisa
name: Anttila, Veli-Jukka
name: Paajanen, Juuso
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: 110309 Infectious Diseases
subject: Plant Biology
subject: 60506 Virology

description: Patients with haematological malignancies have an increased susceptibility for COVID-19 and higher mortality. They may also have prolonged symptoms and viral shedding. Clinical trials have not specifically addressed the management of this patient group. We present a lymphoma patient with COVID-19 who was treated with remdesivir, and a literature review of similar cases. SARS-CoV-2 RT-PCR, virus culture and whole-genome sequencing were performed from nasopharyngeal swabs and antibody testing from serum. In addition, SARS-CoV-2 nucleocapsid antigen was tested from serum. Medline was searched for reported cases of lymphoma and COVID-19 treated with remdesivir. The patient was undergoing lymphoma treatment including chemotherapy, rituximab and prednisolone. After diagnosis of COVID-19, broad-spectrum antibiotics were administered due to neutropenia and fever. After 20 d of fever with no signs of co-infection, remdesivir was initiated with rapid response. The treatment was continued for 4 d. Serum SARS-CoV-2 antibody tests were negative 20, 30 and 66 d from symptom onset. Before starting remdesivir, the SARS-CoV-2 PCR and virus culture from the nasopharynx and serum antigen test were positive. From earlier reports, we identified a total of eleven cases of lymphoma and COVID-19 treated with remdesivir accompanied by other antivirals and anti-inflammatory agents. As shown in this and earlier reports on lymphoma patients, the clinical course of COVID-19 may be protracted and a humoral immune response may remain absent. In addition, optimal management remains undecided. The presented patient responded well to a short course of remdesivir.
Supplementary Materials from Mechanical tuning of mammalian sperm behaviour by hyperactivation, rheology and substrate adhesion: a numerical exploration
Creators: name: Ishimoto, Kenta
name: Gaffney, Eamonn A.
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: 110601 Biomechanics
subject: FOS: Health sciences
subject: Computational Biology

description: Electronic supplementary materials
Forensic-paternity effectiveness and genetics population analysis of six non-CODIS mini-STR loci (D1S1656, D2S441, D6S1043, D10S1248, D12S391, D22S1045) and SE33 in Mestizo and Amerindian populations from Mexico
Creators: name: Nelsi Burguete-Argueta
name: Cruz, Braulio Martínez De La
name: Camacho-Mejorado, Rafael
name: Santana, Carla
name: Noris, Gino
name: López-Bayghen, Esther
name: Arellano-Galindo, José
name: Majluf-Cruz, Abraham
name: Meraz-Ríos, Marco Antonio
name: Gómez, Rocío
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified

description: Background: STRs are powerful tools intensively used in forensic and kinship studies. Aim: In order to assess the effectiveness of non-CODIS genetic markers in forensic and paternity tests, the genetic composition of six mini short tandem repeats—mini-STRs—(D1S1656, D2S441, D6S1043, D10S1248, D12S391, D22S1045) and the microsatellite SE33 in Mestizo and Amerindian populations from Mexico were studied. Subjects and methods: Using multiplex polymerase chain reactions and capillary electrophoresis, this study genotyped all loci from 870 chromosomes and evaluated the statistical genetic parameters. Results: All mini-STRs studied were in agreement with HW and linkage equilibrium; however, an important HW departure for SE33 was found in the Mestizo population (p ≤ 0.0001). Regarding paternity and forensic statistical parameters, high values of combined power discrimination and mean power of exclusion were found using these seven markers. The principal co-ordinate analysis based on allele frequencies of three mini-STRs showed the complex genetic architecture of the Mestizo population. Conclusion: The results indicate that this set of loci is suitable to genetically identify individuals in the Mexican population, supporting its effectiveness in human identification casework. In addition, these findings add new statistical values and emphasise the importance of the use of non-CODIS markers in complex populations in order to avoid erroneous assumptions.
title: OFROM: interview avec unine11c09d
Creators: name: Delafontaine, François
name: Claivaz, Amélie
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.99df75xn.v2#88ee02d2753686b958bb603a123e3b1f26183651
title: Klimagipfelkunst. Kunst und politisches Event, 1972-2022
Creators: name: Burchert, Linn
Publisher: name: ZZF - Leibniz-Zentrum für Zeithistorische Forschung: Visual History
Year: 2022

description: Das Projekt untersucht erstmals die „Klimagipfelkunst“ als einen Korpus, um daran exemplarisch Spezifika und Entwicklungen im Verhältnis von Kunst zu Politik, Gesellschaft und Wirtschaft seit den 1970er Jahren zu eruieren. Es macht sich vor diesem Hintergrund zur Aufgabe, Positionierungen und Institutionalisierungen der Kunst im Rahmen politischer Gipfel zu untersuchen. Durch Workshops und Kooperationen soll die Thematik zudem auf weitere Anlässe erweitert werden, beispielsweise auf Kunstprojekte anlässlich von G8- oder G20-Gipfeln, Weltwirtschaftsforen oder auch von politischen und institutionellen Jahrestagen.
SARS-CoV-2 seroprevalence in Portugal following the third epidemic wave: results of the second National Serological Survey (ISN2COVID-19)
Creators: name: Kislaya, Irina
name: Gonçalves, Paulo
name: Gómez, Verónica
name: Gaio, Vânia
name: Roquette, Rita
name: Barreto, Marta
name: Sousa-Uva, Mafalda
name: Torres, Ana Rita
name: Santos, Joana
name: Matos, Rita
name: Manita, Carla
name: Santos, João Almeida
name: Soeiro, Sofia
name: de Sousa, Rita
name: Costa, Inês
name: Verdasca, Nuno
name: Guiomar, Raquel
name: Rodrigues, Ana Paula
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Integrated approaches to surveillance of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection are important for public health actions. The 2nd National Serological Survey (ISN2COVID-19) aimed to characterize the extent of SARS-CoV-2 infection and vaccine-induced response in the Portuguese population following the third epidemic wave and the launch of the vaccination campaign. A cross-sectional study was performed using data on 8463 Portuguese 1–79 years of age, collected in February and March, 2021. SARS-CoV-2 IgM and IgG (anti-nucleoprotein and anti-spike) antibodies were determined in serum samples using Abbott Architect chemiluminescent microparticle assays. Post-infection and vaccine-induced seroprevalence with 95% confidence intervals (95%CI) were estimated in the overall sample and stratified by population characteristics. The estimated seroprevalence was 15.5% (95%CI:14.6–16.5%), of which 13.5% (95%CI: 12.6–14.4%) was attributable to natural infection and 2.0% (95%CI:1.7–2.4%) to vaccination. The lowest seroprevelence was observed in persons aged 70–79 years (8.9% 95%CI:6.8–11.6), while seroprevalence in children (14.3%; 95%CI:11.5–17.6%) and adolescents (12.9%; 95%CI:10.5–15.7%) was similar to that of persons aged between 20 and 69 years. Of seropositive individuals, 22.6% (95%CI:19.7–25.9%) did not report any symptoms in 6 months prior to interview. Of persons with completed vaccination (2-doses), 98.6% (95%CI: 93.0–99.7%) had specific IgG (anti-S) antibodies. After the third epidemic wave, the post-infection SARS-CoV-2 seroprevalence was 1.7 times higher than the cumulative incidence based on PCR-testing, but was higher (2.7 times) in children may be due to the high proportion of asymptomatic and mild infections.
title: Pauline Fréour, "Sida : les promesses de la trithérapie allégée"
Creators: name: Fréour, Pauline
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Extrait du site LeFigaro.fr.
description: Source: http://www.calames.abes.fr/pub/ms/Calames-20193111232830357
description: created: start=2010;end=2017