Resource Collection for a Connectome and Analysis of the Adult Drosophila Central Brain
Creators: name: Scheffer, Louis
name: Xu, C. Shan
name: Januszewski, Michal
name: Zhiyuan Luo
name: Takemura, Shin-Ya
name: Hayworth, Kenneth
name: Huang, Gary
name: Shinomiya, Kazunori
name: Maitin-Shepard, Jeremy
name: Berg, Stuart
name: Clements, Jody
name: Hubbard, Philip
name: Katz, William
name: Umayam, Lowell
name: Tingting Zhao
name: Ackerman, David
name: Bogovic, John
name: Dolafi, Tom
name: Kainmueller, Dagmar
name: Kawase, Takashi
name: Khairy, Khaled
name: Neubarth, Nicole
name: Olbris, Donald J.
name: Otsuna, Hideo
name: Trautman, Eric T.
name: Ito, Masayoshi
name: Goldammer, Jens
name: Wolff, Tanya
name: Svirskas, Robert
name: Schlegel, Philipp
name: Neace, Erika R.
name: Knecht, Christopher J.
name: Alvarado, Chelsea X.
name: Bailey, Dennis
name: Ballinger, Samantha
name: Borycz, Jolanta A.
name: Canino, Brandon
name: Duclos, Octave
name: Eubanks, Bryon
name: Finley, Samantha
name: Forknall, Nora
name: Francis, Audrey
name: Hopkins, Gary Patrick
name: Joyce, Emily M.
name: Sungjin Kim
name: Kirk, Nicole A.
name: Kovalyak, Julie
name: Lauchie, Shirley A.
name: Lohff, Alanna
name: Maldonado, Charli
name: Manley, Emily A.
name: McLin, Sari
name: Mooney, Caroline
name: Ndama, Miatta
name: Omotara Ogundeyi
name: Okeoma, Nneoma
name: Ordish, Christopher
name: Padilla, Nicholas
name: Patrick, Christopher
name: Phillips, Elliott E.
name: Phillips, Emily M.
name: Rampally, Neha
name: Ribeiro, Caitlin
name: Robertson, Madelaine K.
name: Rymer, Jon Thomson
name: Ryan, Sean M.
name: Sammons, Megan
name: Scott, Anne K.
name: Scott, Ashley L.
name: Shinomiya, Aya
name: Smith, Claire
name: Smith, Kelsey A.
name: Cook, Michael
name: Lindsey, Larry
name: Smith, Natalie L.
name: Takemura, Satoko
name: Tansy Yang
name: Swift, Jackie
name: Dreher, Marisa
name: Talebi, Iris
name: Fairbanks, Kelli
name: Sobeski, Margaret A.
name: Cheatham, Natasha
name: Suleiman, Alia
name: Tarnogorska, Dorota
name: Li, Feng
name: Tenshaw, Emily
name: Tokhi, Temour
name: Walsh, John J.
name: Horne, Jane Anne
name: Parekh, Ruchi
name: Rivlin, Patricia K.
name: Jayaraman, Vivek
name: Ito, Kei
name: Saalfeld, Stephan
name: George, Reed
name: Meinertzhagen, Ian
name: Rubin, Gerald M.
name: Hess, Harald
name: Jain, Viren
name: Bates, Alexander
name: Jefferis, Gregory S.X.E.
name: Costa, Marta
name: Plaza, Stephen
Publisher: name: Janelia Research Campus
Year: 2020
Subjects: subject: 60805 Animal Neurobiology
subject: FOS: Biological sciences
subject: FOS: Biological sciences
subject: Computational Biology
subject: Neuroscience
subject: Physiology
subject: 60807 Animal Structure and Function

description: The neural circuits responsible for animal behavior remain largely unknown. We summarize new methods and present the circuitry of a large fraction of the brain of the fruit fly Drosophila melanogaster. Improved methods include new procedures to prepare, image, align, segment, find synapses in, and proofread such large data sets. We define cell types, refine computational compartments, and provide an exhaustive atlas of cell examples and types, many of them novel. We provide detailed circuits consisting of neurons and their chemical synapses for most of the central brain. We make the data public and simplify access, reducing the effort needed to answer circuit questions, and provide procedures linking the neurons defined by our analysis with genetic reagents. Biologically, we examine distributions of connection strengths, neural motifs on different scales, electrical consequences of compartmentalization, and evidence that maximizing packing density is an important criterion in the evolution of the fly’s brain.<br><b>For interactive queries: </b>https://neuprint.janelia.org<b>For downloading raw data:</b> https://data.io <b>For light-EM mapping</b><br>https://neuronbridge.janelia.org