cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Medical Mapping Methods: Designing Interactions for Self-Care
Creators: name: Winkel, Nathan Edward
Publisher: name: Emily Carr University of Art and Design
Year: 2008
Subjects: subject: Industrial design
valueUri: https://id.loc.gov/authorities/subjects/sh85037199
subject: Human-computer interaction
valueUri: https://id.loc.gov/authorities/subjects/sh88003229
subject: User interfaces (Computer systems)
valueUri: https://id.loc.gov/authorities/subjects/sh88001679
subject: Health promotion
valueUri: https://id.loc.gov/authorities/subjects/sh85059591

description: This project addresses how information and interaction design can create new data collection and interpretation methods that will improve individual efficacy in the management of the chronic illness type 2 diabetes. Medical journaling is an important method of recording and tracking the diabetes condition. Diabetics who journal to self-manage their condition can prolong their lives, gain a better understanding of their disease, and communicate more effectively with medical professionals. To address these issues, this project aims to create a software journaling application on a hand-held personal digital assistant (PDA), where diabetics can journal their day-to-day health-related information, such as blood glucose, diet, exercise and medications. Once data is input into the application, individuals can output the data in the form of visual maps. This allows the individual to look for patterns and trends in the hope of discovering something new about what works for managing the condition. Since health literacy and numeracy are issues for some, the use of an iconic visual language to navigate the user interface makes this application simple, easy to use and interactive. The individual’s effortless gathering of personal data and the ability to see that data in new visual forms offers an alternative to current self-management systems.
The dual functions versus the family purdah and privacy: Architectural analyses of the Sethi Havelis in Peshawar, Pakistan (19th to early 20th century A.D).
Creators: name: Rehman, Abid U.
Publisher: name: University of Leicester
Year: 2023
Subjects: Uncategorized

description: This research analysed architecture of the Sethi Havelis to comprehend their various functions as well as how family purdah and privacy were managed in them. The Sethi Havelis, constructed in over a century (1800-1910), combined domestic, commercial, and communal spaces that formed an enormous Mohallah within the Walled City of Peshawar which once dominated the surrounding regions, and served as symbols of the family's distinctive identity. The Sethi Havelis were previously understood as multi-purpose buildings, where the Sethi's business activities and family life were managed together. However, existing literature could not clearly explain how these diverse activities and the family purdah and privacy were organised in these Havelis. It was unclear whether all Sethi Havelis had dual functions under one roof or whether there were separate buildings for commercial use only. Four categories comprise my classification of the Sethi Havelis. The first category revealed that only two Havelis combined domestic and commercial activities under one roof. The layout of these Havelis demonstrates how strategic placement of the staircases, lobbies and corridors helped regulate varied activities. The second category discusses commercial blocks constructed next to domestic Havelis within the Haveli's fortification wall with shared entrance gates. The third category identifies commercial blocks that were established in a completely separate buildings with their own entrance gates. The last category demonstrates that commercial operations and domestic Havelis were moved from Mohallah Sethian to Bazaar-e-Kalan Road. This study fills a significant gap in the existing literature by providing a comprehensive understanding of the dual functions of these Havelis and the ways in which the family's purdah and privacy were managed in them. The thesis concludes that the dual functions were not organised in all the Sethi Havelis; rather, each Haveli had its own unique system to regulate the domestic and commercial affairs.
Quantum algebra symmetry of the ASEP with second-class particles
Creators: name: Belitsky, V.
name: Schütz, G. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: 82C22, 82C23, 60K35, 17B80

description: We consider a two-component asymmetric simple exclusion process (ASEP) on a finite lattice with reflecting boundary conditions. For this process, which is equivalent to the ASEP with second-class particles, we construct the representation matrices of the quantum algebra $U_q[\mathfrak{gl}(3)]$ that commute with the generator. As a byproduct we prove reversibility and obtain in explicit form the reversible measure. A review of the algebraic techniques used in the proofs is given.
description: 23 pages, presented at conference Particle systems and PDE's - III, 17-19 Dec 2014, Braga, Portugal
CORTEX2 Project Launch Press Release
Creators: name: CORTEX2 Consortium
Publisher: name: Zenodo
Year: 2022
Subjects: Communication, Dissemination, Outreach, Press Release, Extended Reality, Augmented Reality, Virtual Reality, Mixed Reality, Telecooperation

description: The consortium of CORTEX2 — “COoperative Real-Time EXperiences with EXtended reality” — is proud to announce the official start of this ambitious and innovative initiative, funded by the European Commission under the Horizon Europe research and innovation programme.
VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma
Creators: name: Teh, B.T.
name: Saito, R.
name: Todd Auman, J.
name: Kim, W.Y.
name: Kaelin, W.G.
name: Zurlo, G.
name: Kirschner, M.W.
name: Yao, X.
name: Wang, J.
name: Liu, X.-D.
name: Geng, J.
name: Perou, C.M.
name: Fan, C.
name: Chen, X.
name: Wu, T.
name: Zhang, Q.
name: Fan, J.
name: Takada, M.
name: Simon, J.
name: Lawrence, C.
name: Hong, K.
name: Hu, L.
name: Xie, L.
name: Liu, X.
name: Zheng, X.
name: Liao, C.
name: Tan, P.
name: Zhang, J.
name: Parker, J.S.
name: Jonasch, E.
name: Kimryn Rathmell, W.
name: Li, M.
name: Baldwin, A.S.
Publisher: name: American Association for the Advancement of Science
Year: 2018

description: Inactivation of the von Hippel-Lindau (VHL) E3 ubiquitin ligase protein is a hallmark of clear cell renal cell carcinoma (ccRCC). Identifying how pathways affected by VHL loss contribute to ccRCC remains challenging. We used a genome-wide in vitro expression strategy to identify proteins that bind VHL when hydroxylated. Zinc fingers and homeoboxes 2 (ZHX2) was found as a VHL target, and its hydroxylation allowed VHL to regulate its protein stability. Tumor cells from ccRCC patients with VHL loss-of-function mutations usually had increased abundance and nuclear localization of ZHX2. Functionally, depletion of ZHX2 inhibited VHL-deficient ccRCC cell growth in vitro and in vivo. Mechanistically, integrated chromatin immunoprecipitation sequencing and microarray analysis showed that ZHX2 promoted nuclear factor κB activation. These studies reveal ZHX2 as a potential therapeutic target for ccRCC.
Canonical D = 1 supergravity framework for FLRW cosmology
Creators: name: Bogers, M. P.
name: van Holten, J. W.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We construct an extension of standard flat FLRW cosmology with matter, possessing local D = 1, N = 1 proper-time supersymmetry. The fundamental equation for the resulting mini-superspace models of quantum universes is a Dirac-like analogue of the Friedmann and Wheeler-DeWitt equations. We provide solutions of this equation for specific matter configurations based on the supersymmetric O(3) and O(2, 1) sigma-models. It turns out that in the compact model the volume rate of growth of the universe is quantized and non-vanishing due to the zero-point energy of the scalar fields. In the non-compact model the spectrum of the growth rates is continuous but subject to an uncertainty relation involving the scale and the growth factor.
description: 14 pages, no figures
The Chromatin Remodeler BPTF Activates a Stemness Gene-Expression Program Essential for the Maintenance of Adult Hematopoietic Stem Cells
Creators: name: Wang, G.G.
name: Xu, B.
name: Zheng, D.
name: Cai, L.
name: Chen, D.
name: Allison, D.F.
name: Rafii, S.
name: Lu, X.
name: Parker, J.S.
name: Butler, J.M.
name: Lu, R.
Publisher: name: Cell Press
Year: 2018

description: Self-renewal and differentiation of adult stem cells are tightly regulated partly through configuration of chromatin structure by chromatin remodelers. Using knockout mice, we here demonstrate that bromodomain PHD finger transcription factor (BPTF), a component of the nucleosome remodeling factor (NURF) chromatin-remodeling complex, is essential for maintaining the population size of hematopoietic stem/progenitor cells (HSPCs), including long-term hematopoietic stem cells (HSCs). Bptf-deficient HSCs are defective in reconstituted hematopoiesis, and hematopoietic-specific knockout of Bptf caused profound defects including bone marrow failure and anemia. Genome-wide transcriptome profiling revealed that BPTF loss caused downregulation of HSC-specific gene-expression programs, which contain several master transcription factors (Meis1, Pbx1, Mn1, and Lmo2) required for HSC maintenance and self-renewal. Furthermore, we show that BPTF potentiates the chromatin accessibility of key HSC “stemness” genes. These results demonstrate an essential requirement of the chromatin remodeler BPTF and NURF for activation of “stemness” gene-expression programs and proper function of adult HSCs. Wang and colleagues show that a chromatin remodeler, BPTF, sustains appropriate functions of hematopoietic stem/progenitor cells (HSPCs). BPTF loss causes bone marrow failure and anemia. The authors further define a BPTF-dependent gene-expression program in HSPCs, which contains key HSC stemness factors. These results demonstrate an essential requirement of the BPTF-associated chromatin remodelers for HSC functionality and adult hematopoiesis.
Sum-of-squares decompositions for a family of CHSH-like inequalities and their application to self-testing
Creators: name: Bamps, Cédric
name: Pironio, Stefano
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We introduce two families of sum-of-squares (SOS) decompositions for the Bell operators associated with the tilted CHSH expressions introduced in Phys. Rev. Lett. 108, 100402 (2012). These SOS decompositions provide tight upper bounds on the maximal quantum value of these Bell expressions. Moreover, they establish algebraic relations that are necessarily satisfied by any quantum state and observables yielding the optimal quantum value. These algebraic relations are then used to show that the tilted CHSH expressions provide robust self-tests for any partially entangled two-qubit state. This application to self-testing follows closely the approach of Phys. Rev. A 87, 050102 (2013), where we identify and correct two non-trivial flaws.
description: 14 pages, 3 figures
Coorong Dynamics Model ( C D M ) : Model description and performance assessment
Creators: name: Hipsey, Matt
name: Peisheng Huang
name: Zhai, Sherry
name: Busch, Brendan
name: Paraska, Dan
name: Sims, Claire
Publisher: name: Zenodo
Year: 2022
Subjects: Coorong
water quality model
eutrophication
AED
aquatic biogeochemistry
environmental restoration
seagrass
Ruppia
coastal lagoon

description: Description of the Coorong Dynamics Model at v2.0 (June 2020) Cite as:
 Hipsey, M.R., Huang, P., Zhai, S., Busch, B.. Paraska, D., Sims, C., 2022. The Coorong Dynamics Model (CDM) : Model description and performance assessment. Zenodo: DOI: 10.5281/zenodo.7778773
Asteroid Surface Geophysics
Creators: name: Murdoch, Naomi
name: Sanchez, Paul
name: Schwartz, Stephen R.
name: Miyamoto, Hideaki
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Geophysics (physics.geo-ph)
subject: FOS: Physical sciences

description: The regolith-covered surfaces of asteroids preserve records of geophysical processes that have occurred both at their surfaces and sometimes also in their interiors. As a result of the unique micro-gravity environment that these bodies posses, a complex and varied geophysics has given birth to fascinating features that we are just now beginning to understand. The processes that formed such features were first hypothesised through detailed spacecraft observations and have been further studied using theoretical, numerical and experimental methods that often combine several scientific disciplines. These multiple approaches are now merging towards a further understanding of the geophysical states of the surfaces of asteroids. In this chapter we provide a concise summary of what the scientific community has learned so far about the surfaces of these small planetary bodies and the processes that have shaped them. We also discuss the state of the art in terms of experimental techniques and numerical simulations that are currently being used to investigate regolith processes occurring on small-body surfaces and that are contributing to the interpretation of observations and the design of future space missions.
description: 28 pages, 8 figures. Chapter to appear in the book ASTEROIDS IV, (University of Arizona Press) Space Science Series, edited by P. Michel, F. DeMeo and W. Bottke
title: On the Feasibility of Single-Trace Attacks on the Gaussian Sampler Using a CDT
Creators: name: Marzougui, Soundes
name: Kabin, Ievgen
name: Krämer, Juliane
name: Aulbach, Thomas
name: Seifert, Jean-Pierre
Publisher: name: Springer Nature Switzerland
Year: 2023
Subjects: subject: 000 Informatik, Informationswissenschaft, allgemeine Werke::000 Informatik, Wissen, Systeme::000 Informatik, Informationswissenschaft, allgemeine Werke
subject: post-quantum cryptography
subject: lattice-based
subject: side-channel analysis
subject: fault injection
subject: machine-learning
subject: Post-Quanten-Kryptographie
subject: gitterbasierte Seitenkanalanalyse
subject: Fehlerinjektion
subject: maschinelles Lernen

description: We present a single-trace attack against lattice-based KEMs using the cumulative distribution table for Gaussian sampling and execute it in a real-world environment. Our analysis takes a single power trace of the decapsulation algorithm as input and exploits leakage of the Gaussian sampling subroutine to reveal the session key. We investigated the feasibility of the attack on different boards and proved that the power consumption traces become less informative with higher clock frequencies. Therefore, we introduce a machine-learning denoising technique, which enhances the accuracy of our attack and leverages its success rate to 100%. We accomplish the attack on FrodoKEM, a lattice-based KEM and third-round alternate candidate. We execute it on a Cortex-M4 board equipped with an STM32F4 micro-controller clocked at different frequencies.
WHOSE - A Tool for Whole-Session Analysis in IIR
Creators: name: Hienert, Daniel
name: van Hoek, Wilko
name: Weber, Alina
name: Kern, Dagmar
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Retrieval (cs.IR)
subject: FOS: Computer and information sciences

description: One of the main challenges in Interactive Information Retrieval (IIR) evaluation is the development and application of re-usable tools that allow researchers to analyze search behavior of real users in different environments and different domains, but with comparable results. Furthermore, IIR recently focuses more on the analysis of whole sessions, which includes all user interactions that are carried out within a session but also across several sessions by the same user. Some frameworks have already been proposed for the evaluation of controlled experiments in IIR, but yet no framework is available for interactive evaluation of search behavior from real-world information retrieval (IR) systems with real users. In this paper we present a framework for whole-session evaluation that can also utilize these uncontrolled data sets. The logging component can easily be integrated into real-world IR systems for generating and analyzing new log data. Furthermore, due to a supplementary mapping it is also possible to analyze existing log data. For every IR system different actions and filters can be defined. This allows system operators and researchers to use the framework for the analysis of user search behavior in their IR systems and to compare it with others. Using a graphical user interface they have the possibility to interactively explore the data set from a broad overview down to individual sessions.
description: In Advances in Information Retrieval: 37th European Conference on IR Research, ECIR 2015, Vienna, Austria, March 29 - April 2, 2015. Proceedings, Lecture Notes in Computer Science 9022, 172-183
Incommensurate Single-Angle Spiral Orderings of Classical Heisenberg Spins on Zigzag Ladder Lattices
Creators: name: Yuriy, Dublenych
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Exact and rigorous solutions of the ground-state problem for the classical Heisenberg model with nearest-neighbor interactions on two- and three-dimensional lattices composed of zigzag (triangular) ladders are obtained in a very simple way, with the use of a cluster method. It is shown how the geometrical frustration due to the presence of triangles as structural units leads to the emergence of incommensurate spiral orderings and their collinear limits. Interestingly, these orderings are determined by a single angle (along with the signs of the interactions between neighboring spins); therefore, the term "single-angle spiral orderings" is proposed.
description: 5 pages, 8 figures
Amplification of SOX4 promotes PI3K/Akt signaling in human breast cancer
Creators: name: Gatza, M.L.
name: Mehta, G.A.
name: Parker, J.S.
name: Hoadley, K.A.
name: Perou, C.M.
name: Silva, G.O.
Publisher: name: Springer New York LLC
Year: 2017

description: Purpose: The PI3K/Akt signaling axis contributes to the dysregulation of many dominant features in breast cancer including cell proliferation, survival, metabolism, motility, and genomic instability. While multiple studies have demonstrated that basal-like or triple-negative breast tumors have uniformly high PI3K/Akt activity, genomic alterations that mediate dysregulation of this pathway in this subset of highly aggressive breast tumors remain to be determined. Methods: In this study, we present an integrated genomic analysis based on the use of a PI3K gene expression signature as a framework to analyze orthogonal genomic data from human breast tumors, including RNA expression, DNA copy number alterations, and protein expression. In combination with data from a genome-wide RNA-mediated interference screen in human breast cancer cell lines, we identified essential genetic drivers of PI3K/Akt signaling. Results: Our in silico analyses identified SOX4 amplification as a novel modulator of PI3K/Akt signaling in breast cancers and in vitro studies confirmed its role in regulating Akt phosphorylation. Conclusions: Taken together, these data establish a role for SOX4-mediated PI3K/Akt signaling in breast cancer and suggest that SOX4 may represent a novel therapeutic target and/or biomarker for current PI3K family therapies.
Reincarnate Project Launch Press Release
Creators: name: Reincarnate Consortium
Publisher: name: Zenodo
Year: 2022
Subjects: Communication, Dissemination, Press Release, Construction, Circular Economy, Social Innovation

description: The consortium of Reincarnate — “Reincarnation of construction products and materials by slowing down and extending life cycles” — is pleased to share the project's official launch press release.
Immune-related gene expression profiling after PD-1 blockade in non–small cell lung carcinoma, head and neck squamous cell carcinoma, and melanoma
Creators: name: Parker, J.S.
name: Alos, L.
name: Cedrés, S.
name: Galván, P.
name: Comerma, L.
name: Pardo, N.
name: Paré, L.
name: Martínez, A.
name: Nuciforo, P.
name: Gaba, L.
name: Viñolas, N.
name: Arance, A.
name: Prat, A.
name: Vivancos, A.
name: Reguart, N.
name: Pascual, T.
name: Navarro, A.
name: Victoria, I.
name: Fan, C.
name: Felip, E.
Publisher: name: American Association for Cancer Research Inc.
Year: 2017

description: Antibody targeting of the immune checkpoint receptor PD1 produces therapeutic activity in a variety of solid tumors, but most patients exhibit partial or complete resistance to treatment for reasons that are unclear. In this study, we evaluated tumor specimens from 65 patients with melanoma, lung nonsquamous, squamous cell lung or head and neck cancers who were treated with the approved PD1-targeting antibodies pembrolizumab or nivolumab. Tumor RNA before anti-PD1 therapy was analyzed on the nCounter system using the PanCancer 730-Immune Panel, and we identified 23 immune-related genes or signatures linked to response and progression-free survival (PFS). In addition, we evaluated intra- and interbiopsy variability of PD1, PD-L1, CD8A, and CD4 mRNAs and their relationship with tumor-infiltrating lymphocytes (TIL) and PD-L1 IHC expression. Among the biomarkers examined, PD1 gene expression along with 12 signatures tracking CD8 and CD4 T-cell activation, natural killer cells, and IFN activation associated significantly with nonprogressive disease and PFS. These associations were independent of sample timing, drug used, or cancer type. TIL correlated moderately (~0.50) with PD1 and CD8A mRNA levels and weakly (~0.35) with CD4 and PD-L1. IHC expression of PD-L1 correlated strongly with PD-L1 (0.90), moderately with CD4 and CD8A, and weakly with PD1. Reproducibility of gene expression in intra- and interbiopsy specimens was very high (total SD <3%). Overall, our results support the hypothesis that identification of a preexisting and stable adaptive immune response as defined by mRNA expression pattern is reproducible and sufficient to predict clinical outcome, regardless of the type of cancer or the PD1 therapeutic antibody administered to patients.
Dynamic versus Anderson wavepacket localization
Creators: name: Borovkova, Olga V.
name: Lobanov, Valery E.
name: Kartashov, Yaroslav V.
name: Vysloukh, Victor A.
name: Torner, Lluis
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Pattern Formation and Solitons (nlin.PS)
subject: FOS: Physical sciences

description: We address the interplay between two fundamentally different wavepacket localization mechanisms, namely resonant dynamic localization due to collapse of quasi-energy bands in periodic media and disorder-induced Anderson localization. Specifically, we consider light propagation in periodically curved waveguide arrays on-resonance and off-resonance, and show that inclusion of disorder leads to a gradual transition from dynamic localization to Anderson localization, which eventually is found to strongly dominate. While in the absence of disorder, the degree of localization depends critically on the bending amplitude of the waveguide array, when the Anderson regime takes over the impact of resonant effects becomes negligible.
description: 13 pages, 5 figures, to appear in Physical Review A
Future Crop Farming
Creators: name: Spykman, Olivia
name: Ebertseder, Florian
name: Burmeister, Johannes
name: Gehring, Klaus
name: Henkel, Anna
Publisher: name: Zenodo
Year: 2023

description: As crop robots are finding their ways onto farms, they are largely heralded for cost efficiency due to substituting labor-intensive tasks. Despite the advantage of a lower weight than tractors and the option to equip crop robots with precision farming tools, the mere implementation of crop robots in existing plant production systems will not realize their potential. Thus, the established way of farming must also be reconsidered. Ecological issues like the risk of soil erosion and the loss of biodiversity may be addressed in small-scale, highly diversified agricultural systems. Such systems include the cultivation of multiple crops in the same field, e.g., in the form of strip intercropping. In addition to ecological benefits, intercropping approaches may improve the economic resilience of farms against external shocks, which, however, stands in contrast to cost inefficiencies resulting from small-scale structures. The role of crop robots in future farming systems is thus a field to be studied, also from a social perspective: crop robots’ ecological and economic benefits face farmer adoption hesitancy due to uncertain societal reactionsTo understand the potential of crop robots for future-proof agriculture, a systems-oriented evaluation is necessary. The project Future Crop Farming in south-eastern Germany is designed to address this nexus of technology, ecology, and economics under consideration of the underlying social framework by applying the Actor Network Theory. In addition to the agronomic analysis of the crop production system, the field lab will also serve as a platform for communication with different groups of society. This project was funded by the Bavarian State Ministry for Food, Agriculture and Forestry (A/21/17). The field lab is also part of the Horizon Europe project Digitalisation as an Enabler of Agroecological Farming Systems (HORIZON-CL6-2021-FARM2FORK-01-03).
A slicing obstruction from the 10/8 theorem
Creators: name: Donald, Andrew
name: Vafaee, Faramarz
Publisher: name: arXiv
Year: 2015
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 57M25, 57M27

description: From Furuta's $\frac{10}{8}$ theorem, we derive a smooth slicing obstruction for knots in $S^3$ using a spin $4$-manifold whose boundary is $0$-surgery on a knot. We show that this obstruction is able to detect torsion elements in the smooth concordance group and find topologically slice knots which are not smoothly slice.
description: 8 pages, 5 figures, v2: minor revisions throughout, Proc. Amer. Math. Soc. (2016)
A B-Cell Gene Signature Correlates With the Extent of Gluten-Induced Intestinal Injury in Celiac Disease
Creators: name: Laurila, K.
name: Garber, M.E.
name: Jones, W.D.
name: Mäki, M.
name: Adelman, D.C.
name: Saldanha, A.
name: Kaukinen, K.
name: Khosla, C.
name: Parker, J.S.
name: Lähdeaho, M.-L.
name: Khatri, P.
Publisher: name: Elsevier Inc
Year: 2017

description: available: https://www.ncbi.nlm.nih.gov/geo/).
description: Background & Aims Celiac disease (CeD) provides an opportunity to study autoimmunity and the transition in immune cells as dietary gluten induces small intestinal lesions. Methods Seventy-three celiac disease patients on a long-term, gluten-free diet ingested a known amount of gluten daily for 6 weeks. A peripheral blood sample and intestinal biopsy specimens were taken before and 6 weeks after initiating the gluten challenge. Biopsy results were reported on a continuous numeric scale that measured the villus-height–to–crypt-depth ratio to quantify gluten-induced intestinal injury. Pooled B and T cells were isolated from whole blood, and RNA was analyzed by DNA microarray looking for changes in peripheral B- and T-cell gene expression that correlated with changes in villus height to crypt depth, as patients maintained a relatively healthy intestinal mucosa or deteriorated in the face of a gluten challenge. Results Gluten-dependent intestinal damage from baseline to 6 weeks varied widely across all patients, ranging from no change to extensive damage. Genes differentially expressed in B cells correlated strongly with the extent of intestinal damage. A relative increase in B-cell gene expression correlated with a lack of sensitivity to gluten whereas their relative decrease correlated with gluten-induced mucosal injury. A core B-cell gene module, representing a subset of B-cell genes analyzed, accounted for the correlation with intestinal injury. Conclusions Genes comprising the core B-cell module showed a net increase in expression from baseline to 6 weeks in patients with little to no intestinal damage, suggesting that these individuals may have mounted a B-cell immune response to maintain mucosal homeostasis and circumvent inflammation. DNA microarray data were deposited at the GEO repository (accession number: GSE87629
An Oral Selective Alpha-1A Adrenergic Receptor Agonist Prevents Doxorubicin Cardiotoxicity
Creators: name: Huang, W.
name: Jin, J.
name: Simpson, P.C.
name: Jensen, B.C.
name: Ma, A.
name: Parker, J.S.
name: Patterson, C.
name: Hicks, S.T.
name: Beak, J.Y.
Publisher: name: Elsevier Inc
Year: 2017

description: Alpha-1 adrenergic receptors (α1-ARs) play adaptive and protective roles in the heart. Dabuzalgron is an oral selective α1A-AR agonist that was well tolerated in multiple clinical trials of treatment for urinary incontinence, but has never been used to treat heart disease in humans or animal models. In this study, the authors administered dabuzalgron to mice treated with doxorubicin (DOX), a widely used chemotherapeutic agent with dose-limiting cardiotoxicity that can lead to heart failure (HF). Dabuzalgron protected against DOX-induced cardiotoxicity, likely by preserving mitochondrial function. These results suggest that activating cardiac α1A-ARs with dabuzalgron, a well-tolerated oral agent, might represent a novel approach to treating HF.
Motif analysis in directed ordered networks and applications to food webs
Creators: name: Paulau, Pavel V.
name: Feenders, Christoph
name: Blasius, Bernd
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantitative Methods (q-bio.QM)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: The analysis of small recurrent substructures, so called network motifs, has become a standard tool of complex network science to unveil the design principles underlying the structure of empirical networks. In many natural systems network nodes are associated with an intrinsic property according to which they can be ordered and compared against each other. Here, we expand standard motif analysis to be able to capture the hierarchical structure in such ordered networks. Our new approach is based on the identification of all ordered 3-node substructures and the visualization of their significance profile. We present a technique to calculate the fine grained motif spectrum by resolving the individual members of isomorphism classes (sets of substructures formed by permuting node-order). We apply this technique to computer generated ensembles of ordered networks and to empirical food web data, demonstrating the importance of considering node order for food-web analysis. Our approach may not only be helpful to identify hierarchical patterns in empirical food webs and other natural networks, it may also provide the base for extending motif analysis to other types of multi-layered networks.
description: 10 pages, 5 figures, submitted to Scientific Reports
MPEC 2023-F37 : 2023 FM
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 FM

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
title: Machine-Learning Side-Channel Attacks on the GALACTICS Constant-Time Implementation of BLISS
Creators: name: Marzougui, Soundes
name: Wisiol, Nils
name: Gersch, Patrick
name: Krämer, Juliane
name: Seifert, Jean-Pierre
Publisher: name: ACM
Year: 2022
Subjects: subject: 000 Informatik, Informationswissenschaft, allgemeine Werke::000 Informatik, Wissen, Systeme::000 Informatik, Informationswissenschaft, allgemeine Werke
subject: BLISS
subject: GALACTICS
subject: Gaussian sampler
subject: Machine-Learning
subject: postquantum cryptography
subject: side-channel analysis

description: Due to the advancing development of quantum computers, practical attacks on conventional public-key cryptography may become feasible in the next few decades. To address this risk, post-quantum schemes that are assumed to be secure against quantum attacks are being developed. Lattice-based algorithms are promising replacements for conventional schemes, with BLISS being one of the earliest post-quantum signature schemes in this family. However, required subroutines such as Gaussian sampling have been demonstrated to be a risk for the security of BLISS, since implementing Gaussian sampling both efficient and secure with respect to physical attacks is challenging. This paper presents three related power side-channel attacks on GALACTICS, the latest constant-time implementation of BLISS. All attacks are based on power side-channel leakages we identified in the Gaussian sampling and signing algorithm of GALACTICS. To run the attacks, a profiling phase on a device identical to the device under attack is required to train machine learning classifiers. In the attack phase, the leakages of GALACTICS enable the trained classifiers to predict sensitive internal information with high accuracy. We demonstrate the practicality of the attacks by running GALACTICS on a Cortex-M4 and provide proof-of-concept data and implementation for all our attacks.
Investigation of Photocatalytic Activity of Anchored Dysprosium and Praseodymium Complexes on CoFe2O4 in Synthesis of Pyrano[2,3-d]pyrimidine Derivatives
Creators: name: Heravi, Majid Mommahed
name: Daraie, Mansoureh
name: Taiebeh Tamoradi
Publisher: name: figshare
Year: 2020
Subjects: subject: 30302 Nanochemistry and Supramolecular Chemistry
subject: FOS: Chemical sciences
subject: 30502 Natural Products Chemistry
subject: 30205 Non-metal Chemistry
subject: Nuclear Chemistry
subject: 30503 Organic Chemical Synthesis
subject: Organic Chemistry
subject: 30303 Optical Properties of Materials

description: Two hitherto unknown magnetic nanoparticles were prepared through the immobilization of Dysprosium (Dy) and Praseodymium (Pr) Complexes on the surface of CoFe2O4, using commercially available or easily accessible materials under green conditions. They were fully characterized, using, FT-IR, SEM, EDX, ICP-OES, XRD and TGA techniques. Photocatalytic activity of these nanocomposites were successfully examined in the high yielding synthesis of pyrano[2,3-d]pyrimidines, via MCR, involving, barbituric acid, malononitrile and differently substituted benzaldehydes in the UV region (250 nm) at room temperature. The above-mentioned photocatalysts showed excellent recoverability and reusability under the optimal reaction conditions
Attribute-based Access Control on Solid Pods using Privacy-friendly Credentials
Creators: name: Braun, C. H.-J.
name: Käfer, T.
Publisher: name: CEUR-WS.org
Year: 2022
Subjects: Linked Data
Solid
Attribute-based Access Control
Verifiable Credentials
Selective Disclosure

description: Our demo showcases how a user is granted access to resources stored on a Solid Pod, i. e., a web server that adheres to the Solid Protocol, using Web-based Verifiable Credentials. To protect the privacy of the user, we rely on the BBS+ signatures scheme allowing for selective disclosure of only those attributes necessary. We present a PWA where a user can (a) request a Verifiable Credential from another user, (b) store it on their own Solid Pod, and (c) use it to gain access to a resource on a third user’s Solid Pod.
Subtyping sub-Saharan esophageal squamous cell carcinoma by comprehensive molecular analysis
Creators: name: Sharpless, N.E.
name: Liomba, N.G.
name: Hoadley, K.A.
name: Snell, J.M.
name: Wolf, L.L.
name: Shores, C.G.
name: Parker, J.S.
name: Liu, W.
name: Wilkerson, M.D.
name: Jeck, W.R.
name: Mulima, G.
name: Patel, N.
name: Gopal, S.
name: Mlombe, Y.B.
Publisher: name: American Society for Clinical Investigation
Year: 2017

description: Esophageal squamous cell carcinoma (ESCC) is endemic in regions of sub-Saharan Africa (SSA), where it is the third most common cancer. Here, we describe whole-exome tumor/normal sequencing and RNA transcriptomic analysis of 59 patients with ESCC in Malawi. We observed similar genetic aberrations as reported in Asian and North American cohorts, including mutations of TP53, CDKN2A, NFE2L2, CHEK2, NOTCH1, FAT1, and FBXW7. Analyses for nonhuman sequences did not reveal evidence for infection with HPV or other occult pathogens. Mutational signature analysis revealed common signatures associated with aging, cytidine deaminase activity (APOBEC), and a third signature of unknown origin, but signatures of inhaled tobacco use, aflatoxin and mismatch repair were notably absent. Based on RNA expression analysis, ESCC could be divided into 3 distinct subtypes, which were distinguished by their expression of cell cycle and neural transcripts. This study demonstrates discrete subtypes of ESCC in SSA, and suggests that the endemic nature of this disease reflects exposure to a carcinogen other than tobacco and oncogenic viruses.
Bell states and entanglement dynamics on two coupled quantum molecules
Creators: name: Oliveira, P. A.
name: Sanz, L.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: This work provides a complete description of entanglement properties between electrons inside coupled quantum molecules, nanoestructures which consist of two quantum dots. Each electron can tunnel between the two quantum dots inside the molecule, being also coupled by Coulomb interaction. First, it is shown that Bell states act as a natural basis for the description of this physical system, defining the characteristics of the energy spectrum and the eigenstates. Then, the entanglement properties of the eigenstates are discussed, shedding light on the roles of each physical parameters on experimental setup. Finally, a detailed analysis of the dynamics shows the path to generate states with a high degree of entanglement, as well as physical conditions associated with coherent oscillations between separable and Bell states.
description: To be published in Annals of Physics
title: Sea Inside
Creators: name: Sims, Marten
Publisher: name: Emily Carr University of Art and Design
Year: 2012
Subjects: subject: Marine ecology
valueUri: https://id.loc.gov/authorities/subjects/sh85081156
subject: Ocean
valueUri: https://id.loc.gov/authorities/subjects/sh85093871
subject: Nature
valueUri: https://id.loc.gov/authorities/subjects/sh85090277
subject: Design
valueUri: https://id.loc.gov/authorities/subjects/sh85037197
subject: Holism
valueUri: https://id.loc.gov/authorities/subjects/sh85061481

description: The emerging practice of transformation services employs design skills in non-traditional territories and brings together a diversity of intelligences, communication types and frameworks from which to define a problem and develop real-world solutions. Sea Inside is a contribution to the growing discourse around the transformations taking place at the intersection of design, culture and marine ecology. The thesis paper describes the importance of exercising a holistic approach to solving complex problems such as the current crisis threatening our planet’s ocean (and by extension, ourselves). This technique has emerged and developed from my practice of designing a small-scale temporary environment – in the form of a pilot exhibition, interactive features and creative workshops – that attempt to focus participant’s actions and dialogues on the relationship we have with the sea around, and inside us. The project intends to transform people’s perspectives, maintain current positive association and/or provide critical reflection and reflexive opportunities to engage with the subject matter of the ocean. It is hoped that this evolution of the intersections between multiple creative disciplines will support the continued transformation of the participants and encourage actions towards designing and implementing more sustainable ways of living with the ocean in the future.
Extensions and automorphisms of Lie algebras
Creators: name: Bardakov, Valeriy G.
name: Singh, Mahender
Publisher: name: arXiv
Year: 2015
Subjects: subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics
subject: 17B40, 17B56, 17B01, 13N15

description: Let $0 \to A \to L \to B \to 0$ be a short exact sequence of Lie algebras over a field $F$, where $A$ is abelian. We show that the obstruction for a pair of automorphisms in $\Aut(A) \times \Aut(B)$ to be induced by an automorphism in $\Aut(L)$ lies in the Lie algebra cohomology $\Ha^2(B;A)$. As a consequence, we obtain a four term exact sequence relating automorphisms, derivations and cohomology of Lie algebras. We also obtain a more explicit necessary and sufficient condition for a pair of automorphisms in $\Aut\big(L_{n,2}^{(1)}\big) \times \Aut\big(L_{n,2}^{ab}\big)$ to be induced by an automorphism in $\Aut\big(L_{n,2}\big)$, where $L_{n,2}$ is a free nilpotent Lie algebra of rank $n$ and step $2$.
description: 13 pages
A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTERS OF ARTS IN LOGISTICS AND SUPPLYCHAIN MANAGEMENT
Creators: name: ABDUREZAK MUSSEMA
Publisher: name: Zenodo
Year: 2016

description: Since the independency of Eritrea in 1991, Ethiopia became landlocked. As a result, the country has been compelled to use neighbor countries for its imports and exports. In order to ease some of the problems in the transit countries, Ethiopia has started constructing dry ports in its hinterland along the transit corridors. Among the planned dry ports, Modjo and Semera dry ports have become operational. To reap the maximum benefit from those dry ports, the efficient and effective performance of the dry ports is very crucial and to do that it is important to identify factors which influence the performance of dry ports. Therefore, this study tried to examine factors that influence the performance of dry ports from port users perceptions.
Comprehensive molecular characterization of urachal adenocarcinoma reveals commonalities with colorectal cancer, including a hypermutable phenotype
Creators: name: Wobker, S.E.
name: Patel, N.M.
name: Pruthi, R.S.
name: Neil Hayes, D.
name: Milowsky, M.I.
name: Kim, W.Y.
name: Parker, J.S.
name: Hayward, M.C.
name: McGinty, K.A.
name: Black, P.
name: Smith, A.B.
name: Nielsen, M.E.
name: Grilley-Olson, J.E.
name: Weck, K.E.
name: Wallen, E.M.
name: Kardos, J.
name: Woods, M.E.
Publisher: name: American Society of Clinical Oncology
Year: 2017

description: Purpose Urachal adenocarcinoma is a rare type of primary bladder adenocarcinoma that comprises less than 1% of all bladder cancers. The low incidence of urachal adenocarcinomas does not allow for an evidence-based approach to therapy. Transcriptome profiling of urachal adenocarcinomas has not been previously reported.Wehypothesized that an in-depth molecular understanding of urachal adenocarcinoma would uncover rational therapeutic strategies. Patients and Methods We performed targeted exon sequencing and global transcriptome profiling of 12 urachal tumors to generate a comprehensive molecular portrait of urachal adenocarcinoma. A single patient with an MSH6 mutation was treated with the anti-programmed death-ligand 1 antibody, atezolizumab. Results Urachal adenocarcinoma closely resembles colorectal cancer at the level of RNA expression, which extends previous observations that urachal tumors harbor genomic alterations that are found in colorectal adenocarcinoma. A subset of tumors was found to have alterations in genes that are associated with microsatellite instability (MSH2 and MSH6) and hypermutation (POLE).Apatient with anMSH6mutation was treated withimmunecheckpoint blockade, which resulted in stable disease. Conclusion Because clinical trials are next to impossible for patients with rare tumors, precision oncology may be an important adjunct for treatment decisions. Our findings demonstrate that urachal adenocarcinomas molecularly resemble colorectal adenocarcinomas at the level ofRNA expression, are the first report, to our knowledge, of MSH2andMSH6mutations in this disease, and support the consideration of immune checkpoint blockade as a rational therapeutic treatment of this exceedingly rare tumor.
Visible quantum plasmonics from metallic nanodimers
Creators: name: Alpeggiani, Filippo
name: D'Agostino, Stefania
name: Sanvitto, Daniele
name: Gerace, Dario
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We report theoretical evidence that bulk nonlinear materials weakly interacting with highly localized plasmonic modes in ultra-sub-wavelength metallic nanostructures can lead to nonlinear effects at the single plasmon level in the visible range. In particular, the two-plasmon interaction energy in such systems is numerically estimated to be comparable with the typical plasmon linewidths. Localized surface plasmons are thus predicted to exhibit a purely nonclassical behavior, which can be clearly identified by a sub-Poissonian second-order correlation in the signal scattered from the quantized plasmonic field under coherent electromagnetic excitation. We explicitly show that systems sensitive to single-plasmon scattering can be experimentally realized by combining electromagnetic confinement in the interstitial region of gold nanodimers with local infiltration or deposition of ordinary nonlinear materials. We also propose configurations that could allow to realistically detect such an effect with state-of-the-art technology, overcoming the limitations imposed by the short plasmonic lifetime.