cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
EmoStim: A Database of Emotional Film Clips with Discrete and Componential Assessment
Creators: name: Somarathna, Rukshani
name: Vuilleumier, Patrik
name: Mohammadi, Gelareh
Publisher: name: arXiv
Year: 2023
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: Emotion elicitation using emotional film clips is one of the most common and ecologically valid methods in Affective Computing. However, selecting and validating appropriate materials that evoke a range of emotions is challenging. Here we present EmoStim: A Database of Emotional Film Clips as a film library with a rich and varied content. EmoStim is designed for researchers interested in studying emotions in relation to either discrete or componential models of emotion. To create the database, 139 film clips were selected from literature and then annotated by 638 participants through the CrowdFlower platform. We selected 99 film clips based on the distribution of subjective ratings that effectively distinguished between emotions defined by the discrete model. We show that the selected film clips reliably induce a range of specific emotions according to the discrete model. Further, we describe relationships between emotions, emotion organization in the componential space, and underlying dimensions representing emotional experience. The EmoStim database and participant annotations are freely available for research purposes. The database can be used to enrich our understanding of emotions further and serve as a guide to select or create additional materials.
description: This work has been submitted to the IEEE for possible publication
title: ADCO, Ordre cistercien : comptes (1499-1515) (11 H 1162), f. 00277
Creators: name: de la Côte-d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: comptes
subject: Corpus Burgundiae Medii Aevi

description: Ordre cistercien : comptes (1499-1515), Archives départementales de la Côte-d'Or, (11 H 1162). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Ordre cistercien : comptes (1499-1515), Archives départementales de la Côte-d'Or, (11 H 1162), f. 00277, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Texto de Apoio: Orientação Empreendedora
Creators: name: Leite, Cristiana
name: Rua, Orlando Lima
Publisher: name: Zenodo
Year: 2021
Subjects: Orientação empreendedora

description: O presente texto de apoio à docência aborda o tema da Orientação Empreendedora (OE). Especificamente, desenvolve o conceito de OE e as várias dimensões comummente a esta associadas. A organização do texto teve como principal objetivo orientar os estudantes da área da Gestão e, particularmente, das áreas disciplinares de Empreendedorismo e Inovação, para a compreensão do tema da Orientação Empreendedora.
Early aseptic loosening of a mobile-bearing total knee replacement
Creators: name: Kutzner, Ines
name: Hallan, Geir
name: Høl, Paul Johan
name: Furnes, Ove
name: Gøthesen, Øystein
name: Wender Figved
name: Ellison, Peter
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Background and purpose — Registry-based studies have reported an increased risk of aseptic tibial loosening for the cemented Low Contact Stress (LCS) total knee replacement compared with other cemented designs; however, the reasons for this have not been established. We made a retrieval analysis with the aim of identifying the failure mechanism. Patients and methods — We collected implants, cement, tissue, blood, and radiographs from 32 failed LCS Complete cases. Damage to the tibial baseplate and insert was assessed. Exposure to wear products was quantified in 11 cases through analysis of periprosthetic tissue and blood. Implant alignment and bone cement thickness was compared with a control group of 43 non-revised cases. Results — Loosening of the tibial baseplate was the reason for revision in 25 retrievals, occurring at the implant–cement interface in 16 cases. Polishing was observed on the lower surface of the baseplate and correlated to the level of cobalt, chromium, and zirconium in the blood. No evidence of abnormally high polyethylene wear was present. For each 1 mm increase in cement thickness the odds of failure due to aseptic loosening decreased by 61%. Greater varus alignment was associated with a shorter time to failure. The roughness, Ra, of a new LCS baseplate’s lower surface was 3.7 (SD 0.7) µm. Interpretation — Debonding of the tibial component at the implant–cement interface was the predominant cause of tibial aseptic loosening. A thin cement layer may partly explain the poor performance. Furthermore, the comparatively low tibial surface roughness and the lack of a keeled stem may have played a role in the failures observed.
Additional file 3 of Low LINC02147 expression promotes the malignant progression of oral submucous fibrosis
Creators: name: Chen, Jun
name: Li, Wenjie
name: Liu, Binjie
name: Xie, Xiaoli
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 3: Supplementary Results.
Model-assisted analysis of covariance estimators for stepped wedge cluster randomized experiments
Creators: name: Chen, Xinyuan
name: Li, Fan
Publisher: name: arXiv
Year: 2023
Subjects: subject: Methodology (stat.ME)
subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: Stepped wedge cluster randomized experiments (SW-CREs) represent a class of unidirectional crossover designs. Although SW-CREs have become popular, definitions of estimands and robust methods to target estimands under the potential outcomes framework remain insufficient. To address this gap, we describe a class of estimands that explicitly acknowledge the multilevel data structure in SW-CREs and highlight three typical members of the estimand class that are interpretable. We then introduce four analysis of covariance (ANCOVA) working models to achieve estimand-aligned analyses with covariate adjustment. Each ANCOVA estimator is model-assisted, as its point estimator is consistent even when the working model is misspecified. Under the stepped wedge randomization scheme, we establish the finite population Central Limit Theorem for each estimator. We study the finite-sample operating characteristics of the ANCOVA estimators in simulations and illustrate their application by analyzing the Washington State Expedited Partner Therapy study.
Additional file 4 of Co-expression network analysis identifies a gene signature as a predictive biomarker for energy metabolism in osteosarcoma
Creators: name: Zhu, Naiqiang
name: Hou, Jingyi
name: Ma, Guiyun
name: Guo, Shuai
name: Zhao, Chengliang
name: Chen, Bin
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 4: Table S4. KEGG terms for the genes in the yellowlight module.
The Smiling Abbot: Rediscovering a Unique Medieval Effigial Slab
Creators: name: Williams, Howard
name: Smith, Gillian
name: Crane, David
name: Watson, Aaron
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: The article reports on a newly re-discovered fragment of a recumbent effigial slab commemorating Abbot Hywel (‘Howel’), most likely an abbot of the Cistercian house of Valle Crucis, near Llangollen (Denbighs.). The slab was probably carved very early in the fourteenth century, and could have covered the abbot’s burial place. The stone was dislocated and fragmented at an unknown point in the abbey’s history, and most likely removed from the site during the nineteenth-century clearance of the abbey ruins. It was briefly reported on in 1895 and has been lost to scholarship subsequently. If indeed from Valle Crucis, the stone is the only known effigial slab commemorating a Cistercian abbot from Wales, and a rare example from Britain. Given that few similar Cistercian abbatial monuments have been identified from elsewhere, the ‘Smiling Abbot’, although only a fragment, is a significant addition to the known corpus of later medieval mortuary monuments. The article discusses the provenance, dating, identification and significance of the monument, including the abbot’s distinctive smile. The stone sheds new light on mortuary and commemorative practice at Valle Crucis Abbey in the early fourteenth century.
Prime ministers in the age of austerity: an increase in the personalisation of voting behaviour
Creators: name: Lobo, Marina Costa
name: Silva, Frederico Ferreira Da
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Science Policy

description: This article tests the personalisation thesis in Portugal (2002–2015), as well as its causes, focusing on changes in the level of party identification and perceptions of the economy. Portugal is an interesting example given its recent experience of a harsh economic crisis, as well as a decline in party identification. Results confirm a growing exogenous impact of leader evaluations on voting over the period but not in a linear fashion. During the crisis, the growing trend of leader effects for the incumbent party continues for those voters who have a positive perception of the economy. Conversely, for the main opposition party, leader effects are greater for those who perceive the economy as being worse. Thus the crisis operates as a catalyst for leader effects. The impact of leaders is also greater among the de-aligned, the numbers of which rise considerably during the period under analysis. It is voters with no party identification, who use leaders as proxies to a greater extent. These conclusions may extend to further studies on leader effects in Western democracies and help to shed light on the process through which leaders are becoming more relevant in voting decisions.
Additional file 5 of Co-expression network analysis identifies a gene signature as a predictive biomarker for energy metabolism in osteosarcoma
Creators: name: Zhu, Naiqiang
name: Hou, Jingyi
name: Ma, Guiyun
name: Guo, Shuai
name: Zhao, Chengliang
name: Chen, Bin
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 5: Table S5. GO terms for the genes in the pink module.
title: ADCO, Cartulaire de Cîteaux pour les domaines de Saint-Jean de Losne et Losne (XVIIIe siècle), Cart. 198-01 (11 H 1055), 185 folios, f. 0187
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2019
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire

description: Cartulaire de Cîteaux pour les domaines de Saint-Jean de Losne et Losne (XVIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 198-01 (11 H 1055), 185 folios, f. 0187, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les domaines de Saint-Jean de Losne et Losne (XVIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 198-01 (11 H 1055), 185 folios, f. 0187, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Estimating statistical power, posterior probability and publication bias of psychological research using the observed replication rate
Creators: name: Ingre, Michael
name: Nilsonne, Gustav
Publisher: name: figshare
Year: 2018
Subjects: subject: 170110 Psychological Methodology, Design and Analysis
subject: FOS: Psychology
subject: Science Policy

description: This paper has been published in Royal Society Open Science:
http://rsos.royalsocietypublishing.org/content/5/9/181190
In this paper, we show how Bayes’ theorem can be used to better understand the implications of the 36% reproducibility rate of published psychological findings reported by the Open Science Collaboration. We demonstrate a method to assess publication bias, and show that the observed reproducibility rate was not consistent with an unbiased literature. We estimate a plausible range for the prior probability of this body of research, suggesting expected statistical power in the original studies of 48%—75%, producing (positive) findings that were expected to be true 41%—62% of the time. Publication bias was large, assuming a literature with 90% positive findings, indicating that negative evidence was expected to have been observed 55—98 times before one negative result was published. These findings imply that even when studied associations are truly NULL, we expect the literature to be dominated by statistically significant findings.
Social Capital Trends in Germany in the Face of the Covid-19 Pandemic
Creators: name: Burrmann, Ulrike
name: Mutz, Michael
name: Sielschott, Stephan
name: Braun, Sebastian
Publisher: name: Humboldt-Universität zu Berlin
Year: 2022
Subjects: subject: social capital
subject: trust
subject: COVID-19 pandemic
subject: voluntary associations
subject: trend analysis
subject: social cohesion
subject: 301 Soziologie und Anthropologie

description: This research note reports social capital trends in Germany during the COVID-19 pandemic. It is based on a comparison of survey data from 2017/18 and 2020/21, i.e., trends reported here inform about changes of social capital levels during the “second lockdown” of the pandemic, when containment policies were in effect throughout the country. Findings point to stable levels of in-group trust, out-group trust and prosocial attitudes. At the same time, sociability orientations are lower and society is generally perceived as less solidary. Members in voluntary organizations have more social capital compared to non-members—this difference is found before as well as during the pandemic. Regarding that changes are generally small, it can be concluded that the pandemic did neither strengthen social capital considerably, nor did it lead to a massive overall decline of social capital.
A broadband hyperspectral image sensor with high spatio-temporal resolution
Creators: name: Bian, Liheng
name: Wang, Zhen
name: Zhang, Yuzhe
name: Li, Lianjie
name: Zhang, Yinuo
name: Yang, Chen
name: Fang, Wen
name: Zhao, Jiajun
name: Zhu, Chunli
name: Meng, Qinghao
name: Peng, Xuan
name: Zhang, Jun
Publisher: name: arXiv
Year: 2023
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Hyperspectral imaging provides high-dimensional spatial-temporal-spectral information revealing intrinsic matter characteristics. Here we report an on-chip computational hyperspectral imaging framework with high spatial and temporal resolution. By integrating different broadband modulation materials on the image sensor chip, the target spectral information is non-uniformly and intrinsically coupled on each pixel with high light throughput. Using intelligent reconstruction algorithms, multi-channel images can be recovered from each frame, realizing real-time hyperspectral imaging. Following such a framework, we for the first time fabricated a broadband VIS-NIR (400-1700 nm) hyperspectral imaging sensor using photolithography, with an average light throughput of 74.8% and 96 wavelength channels. The demonstrated resolution is 1,024*1,024 pixels at 124 fps. We demonstrated its wide applications including chlorophyll and sugar quantification for intelligent agriculture, blood oxygen and water quality monitoring for human health, textile classification and apple bruise detection for industrial automation, and remote lunar detection for astronomy. The integrated hyperspectral image sensor weighs only tens of grams, and can be assembled on various resource-limited platforms or equipped with off-the-shelf optical systems. The technique transforms the challenge of high-dimensional imaging from a high-cost manufacturing and cumbersome system to one that is solvable through on-chip compression and agile computation.
title: ADCO, Cartulaire du prieuré Notre-Dame de Bonvaux, dépendant du Val-des-Ecoliers (XVe siècle), Dijon, Cart. 228 (27 H), 68 folios, 109 actes (1211-1356), f. 0123
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2011
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire

description: Cartulaire du prieuré Notre-Dame de Bonvaux, dépendant du Val-des-Ecoliers (XVe siècle), Dijon, Archives départementales de la Côte-d'Or, Cart. 228 (27 H), 68 folios, 109 actes (1211-1356). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire du prieuré Notre-Dame de Bonvaux, dépendant du Val-des-Ecoliers (XVe siècle), Dijon, Archives départementales de la Côte-d'Or, Cart. 228 (27 H), 68 folios, 109 actes (1211-1356), f. 0123, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: Dijon
description: Provenance: http://www.wikidata.org/entity/Q7003
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb15250518p
description: Provenance: http://www.idref.fr/02643413X/id
description: Provenance: https://www.geonames.org/6453767
Pertussis toxin neutralizing antibody response after an acellular booster vaccination in Dutch and Finnish participants of different age groups
Creators: name: Knuutila, Aapo
name: Versteegen, Pauline
name: Barkoff, Alex-Mikael
name: van Gageldonk, Pieter
name: Mertsola, Jussi
name: Berbers, Guy
name: He, Qiushui
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology

description: Pertussis incidence has increased in many countries and the disease occurs among all age groups, suggesting the need for booster immunizations through life. In addition to determining the concentration of anti-pertussis toxin (PT) antibodies, the ability of PT neutralizing antibodies (PTNAs) could be used to assess vaccine responses. Altogether 258 participants [7–10-year-old (N = 73), 11–15-year-old (N = 85), 20–35-year-old (N = 50) and 60–70-year-old (N = 50)] were included. Sera were collected before, one month, and one year after a single dose of a three pertussis component containing acellular pertussis vaccine. The adolescents were primed in childhood either by acellular or whole-cell vaccination. PTNA titres were determined by a Chinese hamster ovary cell assay and anti-PT IgG/IgA antibody concentrations by multiplex immunoassay. In all age groups, a significant increase in levels of PTNAs and anti-PT IgG was observed one month after vaccination and remained at least two-fold higher one year post-booster, in comparison to pre-booster. Young adults had the lowest response. The strongest increase in PTNAs was observed in participants who had ≥10 IU/mL concentration of anti-PT IgG antibodies pre-booster. At pre-booster, whole-cell-primed adolescents had higher PTNAs than acellular-primed peers (p = 0.047). One year post-booster, the Finnish whole-cell-primed adolescents had a higher level of PTNAs than acellular-primed adolescents (p = 0.049), however, this was not observed in Dutch adolescents. In conclusion, PTNAs increased after vaccination in all age groups, and the strongest increase was related to the presence of high pre-booster antibodies.
Estimating statistical power, posterior probability and publication bias of psychological research using the observed replication rate
Creators: name: Ingre, Michael
name: Nilsonne, Gustav
Publisher: name: figshare
Year: 2017
Subjects: subject: 170110 Psychological Methodology, Design and Analysis
subject: FOS: Psychology
subject: Science Policy

description: In the present paper, we show how Bayes’ theorem can be used to better understand the implications of the 36% reproducibility rate of published psychological findings that was reported by the OSC (Open Science Collaboration, 2015). We demonstrate a method to assess publication bias, and show that the observed reproducibility rate was not consistent with an unbiased literature. We estimate a plausible range for the prior probability of this research, suggesting that statistical power in the original studies was 42%—73% and producing (positive) findings that were likely to be true 43% to 69% of the time. Publication bias was large, assuming a literature with 90% positive findings, indicating that negative evidence was observed 60—100 times before one negative result was published. These findings imply that even when studied associations are truly NULL, we expect the literature to be dominated by statistically significant findings.
Additional file 6 of Co-expression network analysis identifies a gene signature as a predictive biomarker for energy metabolism in osteosarcoma
Creators: name: Zhu, Naiqiang
name: Hou, Jingyi
name: Ma, Guiyun
name: Guo, Shuai
name: Zhao, Chengliang
name: Chen, Bin
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 6: Table S6. KEGG terms for genes in the pink module.
Pertussis Toxin Neutralizing Antibody Response After an Acellular Booster Vaccination in Dutch and Finnish Participants of Different Age Groups
Creators: name: Knuutila, Aapo
name: Versteegen, Pauline
name: Barkoff, Alex-Mikael
name: van Gageldonk, Pieter
name: Mertsola, Jussi
name: Berbers, Guy
name: He, Qiushui
name: Consortium, Periscope
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology

description: Pertussis incidence has increased in many countries and the disease occurs among all age groups, suggesting the need for booster immunizations through life. In addition to determining the concentration of anti-pertussis toxin (PT) antibodies, the ability of PT neutralizing antibodies (PTNAs) could be used to assess vaccine responses. Altogether 258 participants [7–10-year-old (N = 73), 11–15-year-old (N = 85), 20–35-year-old (N = 50) and 60–70-year-old (N = 50)] were included. Sera were collected before, one month, and one year after a single dose of a three pertussis component containing acellular pertussis vaccine. The adolescents were primed in childhood either by acellular or whole-cell vaccination. PTNA titers were determined by a Chinese hamster ovary cell assay and anti-PT IgG/IgA antibody concentrations by multiplex immunoassay. In all age groups, a significant increase in levels of PTNAs and anti-PT IgG was observed one month after vaccination and remained at least two-fold higher one year post-booster, in comparison to pre-booster. Young adults had the lowest response. The strongest increase in PTNAs was observed in participants who had ≥10 IU/mL concentration of anti-PT IgG antibodies pre-booster. At pre-booster, whole-cell-primed adolescents had higher PTNAs than acellular-primed peers (p = 0.047). One year post-booster, the Finnish whole-cell-primed adolescents had a higher level of PTNAs than acellular-primed adolescents (p = 0.049), however, this was not observed in Dutch adolescents. In conclusion, PTNAs increased after vaccination in all age groups, and the strongest increase was related to the presence of high pre-booster antibodies.
Fusion-inhibition peptide broadly inhibits influenza virus and SARS-CoV-2, including Delta and Omicron variants
Creators: name: Zhao, Hanjun
name: Meng, Xinjie
name: Peng, Zheng
name: Lam, Hoiyan
name: Zhang, Chuyuan
name: Zhou, Xinxin
name: Chan, Jasper Fuk-Woo
name: Kao, Richard Yi Tsun
name: To, Kelvin Kai-Wang
name: Yuen, Kwok-Yung
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology

description: Pandemic influenza virus and SARS-CoV-2 vaiants have posed major global threats to public health. Broad-spectrum antivirals blocking viral entry can be an effective strategy for combating these viruses. Here, we demonstrate a frog-defensin-derived basic peptide (FBP), which broadly inhibits the influenza virus by binding to haemagglutinin so as to block low pH-induced HA-mediated fusion and antagonizes endosomal acidification to inhibit the influenza virus. Moreover, FBP can bind to the SARS-CoV-2 spike to block spike-mediated cell–cell fusion in 293T/ACE2 cells endocytosis. Omicron spike shows a weak cell–cell fusion mediated by TMPRSS2 in Calu3 cells, making the Omicron variant sensitive to endosomal inhibitors. In vivo studies show that FBP broadly inhibits the A(H1N1)pdm09 virus in mice and SARS-CoV-2 (HKU001a and Delta)in hamsters. Notably, FBP shows significant inhibition of Omicron variant replication even though it has a high number of mutations in spike. In conclusion, these results suggest that virus-targeting FBP with a high barrier to drug resistance can be an effective entry-fusion inhibitor against influenza virus and SARS-CoV-2 in vivo.
Improving delivery performance for asymmetric Laplace distributed delivery time in a two-stage supply chain
Creators: name: Bushuev, Maxim A.
name: Brown, Jay R.
name: Rudchenko, Tatiana
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: This paper investigates strategies for improving supply chain delivery timeliness when the delivery time follows an asymmetric Laplace distribution. Delivery performance is measured using a cost-based analytical model which evaluates the expected cost for early and late delivery. This paper presents a set of propositions that define the effect of changes to the parameters of the delivery time distribution on the expected penalty cost for untimely delivery when a supplier uses an optimally positioned delivery window to minimise the expected cost of untimely delivery. The scale parameter increases the expected penalty cost, skewness decreases the cost and the location parameter has no effect on the expected penalty cost. The effects are illustrated in a numerical example with real-world supplier data. The results can be used in developing strategies for improving delivery performance from a supplier’s perspective and define how the delivery time distribution parameters can be modified to decrease the expected penalty cost of untimely delivery. The paper proposes a general approach to modelling delivery performance improvement and can be applied to other delivery time distribution forms. The approach can serve as guidance for practitioners undertaking a programme to improve delivery performance.
Race characterization of Pyrenophora tritici-repentis and sensitivity to propiconazole and pyraclostrobin fungicides
Creators: name: MacLean, Dustin E.
name: Aboukhaddour, Reem
name: Tran, Van Anh
name: Askarian, Homa
name: Strelkov, Stephen E.
name: T. Kelly Turkington
name: Kutcher, Hadley R.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Plant Biology
subject: 60506 Virology

description: Tan spot, caused by Pyrenophora tritici-repentis (Ptr), is one of the most destructive leaf spot diseases of wheat in Canada. Several races of the fungus are known to occur. Wheat growers have adopted fungicides to manage tan spot; however, intensive spraying may lead to development of reduced sensitivity to fungicides in the pathogen. In this study, 62 Ptr isolates were collected from across Saskatchewan and Alberta and characterized to race on a wheat differential set, with confirmation of race designations by polymerase chain reaction. This same set of isolates, and 27 isolates from an earlier study, were also evaluated for sensitivity to propiconazole and pyraclostrobin fungicides by determining the effective concentration of each needed to inhibit radial growth and conidiospore germination by 50%. Races 1 and 2 were predominant in western Canada, with 57% of isolates classified as race 1 and 40% as race 2. In Alberta, race 1 was most common (76%), while in Saskatchewan, it was race 2 (57%). Two of 26 isolates were classified as race 3, which was detected only in Saskatchewan in 2013. There was no evidence of reduced sensitivity of either fungicide in the Ptr isolates examined. This study provides a baseline for Ptr sensitivity to propiconazole and pyraclostrobin to which future collections of the pathogen may be compared.
Fusion-inhibition peptide broadly inhibits influenza virus and SARS-CoV-2 including Delta and Omicron variants
Creators: name: Zhao, Hanjun
name: Meng, Xinjie
name: Peng, Zheng
name: Lam, Hoiyan
name: Zhang, Chuyuan
name: Zhou, Xinxin
name: Chan, Jasper Fuk-Woo
name: Kao, Richard Yi Tsun
name: To, Kelvin K. W.
name: Yuen, Kwok-Yung
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology

description: Pandemic influenza virus and SARS-CoV-2 variants have posed major global threats to public health. Broad-spectrum antivirals blocking viral entry can be an effective strategy for combating these viruses. Here, we demonstrate a frog-defensin-derived basic peptide (FBP) which broadly inhibits influenza virus by binding to haemagglutinin to block low pH induced HA-mediated fusion and antagonizes endosomal acidification to inhibit influenza virus. Moreover, FBP can bind to SARS-CoV-2 spike to block spike mediated cell-cell fusion in 293T/ACE2 cells through endocytosis. Omicron spike shows weak cell-cell fusion mediated by TMPRSS2 in Calu3 cells, making Omicron variant sensitive to endosomal inhibitors. In vivo studies show that FBP broadly inhibits A(H1N1)pdm09 virus in mice and SARS-CoV-2 (HKU001a and Delta)in hamsters. Notably, FBP shows significant inhibition on Omicron variant replication even though it has high number mutations in spike. In conclusion, these results suggest that virus-targeting FBP with high barrier to drug resistance can be an effective entry-fusion inhibitor against influenza virus and SARS-CoV-2 in vivo.
Blind Graph Matching Using Graph Signals
Creators: name: Liu, Hang
name: Scaglione, Anna
name: Wai, Hoi-To
Publisher: name: arXiv
Year: 2023
Subjects: subject: Signal Processing (eess.SP)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Classical graph matching aims to find a node correspondence between two unlabeled graphs of known topologies. This problem has a wide range of applications, from matching identities in social networks to identifying similar biological network functions across species. However, when the underlying graphs are unknown, the use of conventional graph matching methods requires inferring the graph topologies first, a process that is highly sensitive to observation errors. In this paper, we tackle the blind graph matching problem with unknown underlying graphs directly using observations of graph signals, which are generated from graph filters applied to graph signal excitations. We propose to construct sample covariance matrices from the observed signals and match the nodes based on the selected sample eigenvectors. Our analysis shows that the blind matching outcome converges to the result obtained with known graph topologies when the signal sampling size is large and the signal noise is small. Numerical results showcase the performance improvement of the proposed algorithm compared to matching two estimated underlying graphs learned from the graph signals.
description: This work has been accepted by the IEEE for possible publication
Development of improved methods for predictive modelling of G protein-coupled receptors
Creators: name: THOMAS COUDRAT
Publisher: name: Monash University
Year: 2017
Subjects: subject: 30402 Biomolecular Modelling and Design
subject: FOS: Chemical sciences

description: G protein-coupled receptors (GPCRs) are a superfamily of transmembrane proteins that play crucial roles in cell physiology. Being key drug targets in many diseases, drug discovery efforts harness structural information about these receptors to rationally design drugs in the field of structure-based drug design (SBDD). This thesis presents the development of computational tools to manage and assess large GPCR structural model datasets, applies these tools to define key features linked with the best performing models in SBDD and integrates this knowledge into a novel computational workflow that predicts new GPCR models, which may offer new opportunities in SBDD programs.
Comparison between insulin degludec/liraglutide treatment and insulin glargine/lixisenatide treatment in type 2 diabetes: a systematic review and meta-analysis
Creators: name: Xiaoling Cai
name: Xueying Gao
name: Wenjia Yang
name: Linong Ji
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Aim: To evaluate the efficacy and adverse effects of IDegLira and IGlarLixi treatment and to perform a comparison between two strategies. Methods: The registration number is CRD42017053952. Randomized controlled trials of IGlarLixi treatment or IDegLira treatment compared with placebo or active hypoglycemic agents in type 2 diabetes were included. Results: Eight trials were included. The absolute HbA1c change relative to baseline after IGlarLixi treatment was −1.50% with significance (95% CI, −1.89% to −1.12%, p Conclusion: Glucose control of IGlarLixi treatment or IDegLira treatment was significantly lower than that at baseline. Comparisons between the two treatment groups indicated no significant differences between groups in absolute HbA1c changes or body weight changes relative to baseline.
Seasonal variation in natural abundance of δ13C and 15N in Salicornia brachiata Roxb. populations from a coastal area of India
Creators: name: Doongar R. Chaudhary
name: Juyoung Seo
name: Hojeong Kang
name: Rathore, Aditya P.
name: Bhavanath Jha
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: High and fluctuating salinity is characteristic for coastal salt marshes, which strongly affect the physiology of halophytes consequently resulting in changes in stable isotope distribution. The natural abundance of stable isotopes (δ13C and δ15N) of the halophyte plant Salicornia brachiata and physico-chemical characteristics of soils were analysed in order to investigate the relationship of stable isotope distribution in different populations in a growing period in the coastal area of Gujarat, India. Aboveground and belowground biomass of S. brachiata was collected from six different populations at five times (September 2014, November 2014, January 2015, March 2015 and May 2015). The δ13C values in aboveground (−30.8 to −23.6 ‰, average: −26.6 ± 0.4 ‰) and belowground biomass (−30.0 to −23.1 ‰, average: −26.3 ± 0.4 ‰) were similar. The δ13C values were positively correlated with soil salinity and Na concentration, and negatively correlated with soil mineral nitrogen. The δ15N values of aboveground (6.7–16.1 ‰, average: 9.6 ± 0.4 ‰) were comparatively higher than belowground biomass (5.4–13.2 ‰, average: 7.8 ± 0.3 ‰). The δ15N values were negatively correlated with soil available P. We conclude that the variation in δ13C values of S. brachiata was possibly caused by soil salinity (associated Na content) and N limitation which demonstrates the potential of δ13C as an indicator of stress in plants.
Age-related differences in structure and function of nasal epithelial cultures from healthy children and elderly people.
Creators: name: Balázs, Anita
name: Millar-Büchner, Pamela
name: Mülleder, Michael
name: Farztdinov, Vadim
name: Szyrwiel, Lukasz
name: Addante, Annalisa
name: Kuppe, Aditi
name: Rubil, Tihomir
name: Drescher, Marika
name: Seidel, Kathrin
name: Stricker, Sebastian
name: Eils, Roland
name: Lehmann, Irina
name: Sawitzki, Birgit
name: Röhmel, Jobst
name: Ralser, Markus
name: Mall, Marcus A
Publisher: name: The Francis Crick Institute
Year: 2022
Subjects: Synthetic Biology
Chemical Biology & High Throughput
Ecology,Evolution & Ethology
Metabolism
Computational & Systems Biology

description: The nasal epithelium represents the first line of defense against inhaled pathogens, allergens, and irritants and plays a key role in the pathogenesis of a spectrum of acute and chronic airways diseases. Despite age-dependent clinical phenotypes triggered by these noxious stimuli, little is known about how aging affects the structure and function of the airway epithelium that is crucial for lung homeostasis and host defense. The aim of this study was therefore to determine age-related differences in structural and functional properties of primary nasal epithelial cultures from healthy children and non-smoking elderly people. To achieve this goal, highly differentiated nasal epithelial cultures were established from nasal brushes at air-liquid interface and used to study epithelial cell type composition, mucin (MUC5AC and MUC5B) expression, and ion transport properties. Furthermore, we determined age-dependent molecular signatures using global proteomic analysis. We found lower numeric densities of ciliated cells and higher levels of MUC5AC expression in cultures from children vs. elderly people. Bioelectric studies showed no differences in basal ion transport properties, ENaC-mediated sodium absorption, or CFTR-mediated chloride transport, but detected decreased calcium-activated TMEM16A-mediated chloride secretory responses in cultures from children vs. elderly people. Proteome analysis identified distinct age-dependent molecular signatures associated with ciliation and mucin biosynthesis, as well as other pathways implicated in aging. Our data identified intrinsic, age-related differences in structure and function of the nasal epithelium and provide a basis for further studies on the role of these findings in age-dependent airways disease phenotypes observed with a spectrum of respiratory infections and other noxious stimuli.
Цифровая магнитовариационная станция (ЦАМВС)
Creators: name: Любимов В.В., Кириаков В.Х.
Publisher: name: Zenodo
Year: 2012
Subjects: Магнитное поле, магнитная обсерватория, магнитовариационная станция, магнитометры, магнитные измерения

description: Разработанная в ИЗМИРАН цифровая автоматическая магнитовариационная станция выполнена на базе кварцевых магнитных датчиков, включает в себя три измерительных канала (D, H, Z), каждый из которых имеет измерительный диапазон 0…± 6000 нТл. Станция предназначена для проведения работ в автономном автоматическом режиме в условиях не обслуживаемых и редко обслуживаемых пунктов наблюдений, а также для проведения работ в условиях больших изменений температуры окружающей среды.
The first dinosaur egg from the Lower Cretaceous of Western Siberia, Russia
Creators: name: Skutschas, Pavel P.
name: Markova, Valentina D.
name: Boitsova, Elizaveta A.
name: Leshchinskiy, Sergey V.
name: Ivantsov, Stepan V.
name: Maschenko, Evgeny N.
name: Averianov, Alexander O.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Computational Biology

description: The Lower Cretaceous Ilek Formation in Western Siberia (Russia) has yielded various vertebrate fossils, including skeletal remains of dinosaurs. Here we report on a fragmentary theropod egg from the vertebrate locality Shestakovo 3 of the Ilek Formation in Kemerovo Province. We assign the specimen to the oogenus Prismatoolithus (oofamily Prismatoolithidae) as Prismatoolithus ilekensis oosp. nov., on the basis of the following unique combination of characters: ovoid-shaped egg; thin eggshell 300–330 μm thick; angustiprismatic morphotype; eggshell with three different layers; gradual transition between mammillary layer and prismatic layer; abrupt contact between prismatic layer and external layer; mammillary layer to prismatic layer to external layer thickness ratio is 1:3:0.6; prismatic layer with ill-defined squamatic texture; angusticanaliculate pore system; and smooth outer surface. Like other Early Creataceous Prismatoolithus, the egg of Prismatoolithus ilekensis oosp. nov. was laid by a small bodied theropod dinosaur (troodontid or primitive bird) and this taxonomic attribution is supported by results of our phylogenetic analysis. Prismatoolithus ilekensis oosp. nov. is the first Early Cretaceous ootaxon from Russia. urn:lsid:zoobank.org:act:734EAD40-86C3-488B-A61E-B5FF7378BC0E
Полевая цифровая магнитовариационная станция
Creators: name: Любимов В.В., Кириаков В.Х.
Publisher: name: Zenodo
Year: 2012
Subjects: Магнитное поле, магнитные измерения, магнитная обсерватория, магнитовариационная станция, магнитометры,

description: Полевая цифровая магнитовариационная станция является высокочувствительным магнитометром, выполненным на основе кварцевых магнитных датчиков системы В.Н.Боброва в виде переносного прибора, и предназначена для непрерывной регистрации вариаций трех составляющих Х (Н), Y (D), Z вектора магнитной индукции (ВМИ) поля Земли, а также для исследования полей, создаваемых искусственными источниками и для специальных целей.
title: ADCO, Cartulaire de Cîteaux pour les possessions de Dijon et du Dijonnais (XVe siècle), Cart. 175 (11 H 479), 115 folios, f. 0087
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2017
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire de Cîteaux pour les possessions de Dijon et du Dijonnais (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 175 (11 H 479), 115 folios, f. 0087, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les possessions de Dijon et du Dijonnais (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 175 (11 H 479), 115 folios, f. 0087, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v