title: ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸Ñ Ñ Ð¸Ð¼Ð¸ÑÐµÑÐºÐ¸Ñ Ð¸ Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸ Ð°ÐºÑÐ¸Ð²Ð½ÑÑ Ð²ÐµÑÐµÑÑÐ², Ð¸ÑÐ¿Ð¾Ð»ÑÐ·ÑÐµÐ¼ÑÑ Ð² ÐºÐ°ÑÐµÑÑÐ²Ðµ Ð¿ÑÐ¸ÑÐ¾Ð´Ð½ÑÑ Ð¾Ð½ÐºÐ¾Ð¿ÑÐ¾ÑÐµÐºÑÐ¾ÑÐ¾Ð², Ð² ÐºÐ¾ÑÐ½ÐµÐ¿Ð»Ð¾Ð´Ð°Ñ ÑÐµÐ´ÑÐºÐ¸ Ð¿Ð¾ÑÐµÐ²Ð½Ð¾Ð¹ Raphanus Sativus L.
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Study of the content of chemical and biologically active substances used as natural oncoprotectors in root crops of the radish seed Raphanus Sativus L.
Creators: name: ÐÐ¾Ð²Ð°Ð»ÐµÐ²ÑÐºÐ°Ñ, ÐÐ»Ð¸Ð·Ð°Ð²ÐµÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: ÑÐµÐ´ÑÐºÐ° Ð¿Ð¾ÑÐµÐ²Ð½Ð°Ñ
Ð°Ð½ÑÐ¸Ð¾ÐºÑÐ¸Ð´Ð°Ð½ÑÑ
Ñ Ð¸Ð¼Ð¸Ð¾ÑÐµÑÐ°Ð¿Ð¸Ñ Ð² ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½Ð¾Ð¹ Ð¾Ð½ÐºÐ¾Ð»Ð¾Ð³Ð¸Ð¸
Ð´Ð¸Ð¾ÐºÑÐ°Ð´ÑÑ
Ð¿ÑÐ¸ÑÐ¾Ð´Ð½ÑÐµ Ð¾Ð½ÐºÐ¾Ð¿ÑÐ¾ÑÐµÐºÑÐ¾ÑÑ
radish seed
antioxidants
chemotherapy in experimental oncology
dioxadet
natural onkoprotektors

description: ÐÐ° 61 Ñ., 4 ÑÐ°Ð±Ð»., 8 ÑÐ¸Ñ. Ð Ð²ÑÐ¿ÑÑÐºÐ½Ð¾Ð¹ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð½Ð° ÑÐµÐ¼Ñ Â«ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸Ñ ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ¸Ñ Ð¸ Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸ Ð°ÐºÑÐ¸Ð²Ð½ÑÑ Ð²ÐµÑÐµÑÑÐ², Ð¸ÑÐ¿Ð¾Ð»ÑÐ·ÑÐµÐ¼ÑÑ Ð² ÐºÐ°ÑÐµÑÑÐ²Ðµ Ð¿ÑÐ¸ÑÐ¾Ð´Ð½ÑÑ Ð¾Ð½ÐºÐ¾Ð¿ÑÐ¾ÑÐµÐºÑÐ¾ÑÐ¾Ð², Ð² ÐºÐ¾ÑÐ½ÐµÐ¿Ð»Ð¾Ð´Ð°Ñ ÑÐµÐ´ÑÐºÐ¸ Ð¿Ð¾ÑÐµÐ²Ð½Ð¾Ð¹ Raphanus Sativus L.Â» Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ñ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¹, Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð½ÑÑ ÐºÐ°Ðº Ð² Ð¾Ð±Ð»Ð°ÑÑÐ¸ Ð¼ÐµÐ´Ð¸ÑÐ¸Ð½ÑÐºÐ¾Ð¹ Ð±Ð¸Ð¾ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ð¸, ÑÐ°Ðº Ð¸ Ð² Ð¾Ð±Ð»Ð°ÑÑÐ¸ Ð±Ð¸Ð¾ÑÐ¸Ð¼Ð¸Ð¸ ÑÐ°ÑÑÐµÐ½Ð¸Ð¹. ÐÐµÑÐ²Ð¾Ðµ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¹ Ð·Ð°ÐºÐ»ÑÑÐ°Ð»Ð¾ÑÑ Ð² Ð¸Ð·ÑÑÐµÐ½Ð¸Ð¸, Ð½Ð° ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½Ð¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð¿ÐµÑÐµÐ²Ð¸Ð²Ð°ÐµÐ¼Ð¾Ð³Ð¾ ÑÑÐ°Ð¼Ð¼Ð° ÑÐ°ÐºÐ° ÑÐ¸ÑÐ½Ð¸ÐºÐ° Ñ ÐºÑÑÑ, Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð¾Ð¿ÑÑÐ¾Ð»ÐµÐ²Ð¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¾ÑÐµÑÐµÑÑÐ²ÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÐ°ÑÐ¼Ð°ÐºÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ° Ð´Ð¸Ð¾ÐºÑÐ°Ð´ÑÑ, ÑÐ¸Ð½ÑÐµÐ·Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð³Ð¾ Ð² ÐÐÐÐ¦ Ð¾Ð½ÐºÐ¾Ð»Ð¾Ð³Ð¸Ð¸ Ð¸Ð¼.Ð.Ð.ÐÐµÑÑÐ¾Ð²Ð° (Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³). ÐÑÐ¸ÑÐµÑÐ¸ÐµÐ¼ Ð¾ÑÐµÐ½ÐºÐ¸ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð´Ð¸Ð¾ÐºÑÐ°Ð´ÑÑÐ° ÑÐ²Ð¸Ð»Ð¸ÑÑ ÑÐµÐ°ÐºÑÐ¸Ð²Ð½ÑÐµ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ ÑÐ¸ÑÐ¾Ð¼Ð¾ÑÑÐ¾Ð¼ÐµÑÑÐ¸ÑÐµÑÐºÐ¸Ñ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸Ðº ÑÐ°ÐºÐ¾Ð²ÑÑ ÐºÐ»ÐµÑÐ¾Ðº Ð°ÑÑÐ¸ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð¶Ð¸Ð´ÐºÐ¾ÑÑÐ¸ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑ. Ð ÐµÐ·ÑÐ»ÑÑÐ°ÑÑ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ¾Ð² Ð¿Ð¾Ð´ÑÐ²ÐµÑÐ´Ð¸Ð»Ð¸ Ð°Ð½ÑÐ¸ÐºÐ°Ð½ÑÐµÑÐ¾Ð³ÐµÐ½Ð½ÑÐ¹ ÑÑÑÐµÐºÑ Ð´Ð¸Ð¾ÐºÑÐ°Ð´ÑÑÐ°. ÐÑÐ¾ÑÑÐ¼ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸ÐµÐ¼ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¹ ÑÐ²Ð¸Ð»Ð¾ÑÑ ÑÑÐ°Ð²Ð½Ð¸ÑÐµÐ»ÑÐ½Ð¾Ðµ Ð¸Ð·ÑÑÐµÐ½Ð¸Ðµ Ð±Ð¸Ð¾ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐ¾ÑÑÐ°Ð²Ð° ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ ÑÐ¾ÑÑÐ¾Ð² ÑÐµÐ´ÑÐºÐ¸ Ð¿Ð¾ÑÐµÐ²Ð½Ð¾Ð¹ Raphanus Sativus L. - Ð¿ÑÐ¸ÑÐ¾Ð´Ð½Ð¾Ð³Ð¾ Ð¸ÑÑÐ¾ÑÐ½Ð¸ÐºÐ° Ð°Ð½ÑÐ¸Ð¾ÐºÑÐ¸Ð´Ð°Ð½ÑÐ¾Ð². ÐÐ»Ñ Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ Ð¼ÐµÑÐ°Ð±Ð¾Ð»Ð¾Ð¼Ð½Ð¾Ð³Ð¾ ÑÐ¾ÑÑÐ°Ð²Ð° ÑÐ°ÑÑÐ¸ÑÐµÐ»ÑÐ½Ð¾Ð³Ð¾ ÑÑÑÑÑ Ð¿ÑÐ¸Ð¼ÐµÐ½ÑÐ»ÑÑ ÑÐ¾Ð²ÑÐµÐ¼ÐµÐ½Ð½ÑÐ¹ Ð¼ÐµÑÐ¾Ð´ Ð³Ð°Ð·Ð¾-Ð¶Ð¸Ð´ÐºÐ¾ÑÑÐ½Ð¾Ð¹ ÑÑÐ¾Ð¼Ð°ÑÐ¾Ð³ÑÐ°ÑÐ¸Ð¸ Ñ Ð¼Ð°ÑÑ-ÑÐ¿ÐµÐºÑÑÐ¾Ð¼ÐµÑÑÐ¸ÐµÐ¹. ÐÐ¾ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐ°Ð¼ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð±ÑÐ» Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½ ÑÐ¾ÑÑ ÑÐµÐ´ÑÐºÐ¸ Ð¿Ð¾ÑÐµÐ²Ð½Ð¾Ð¹ Kirmiri Ñ Ð¼Ð°ÐºÑÐ¸Ð¼Ð°Ð»ÑÐ½ÑÐ¼ ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸ÐµÐ¼ ÑÐµÐ½Ð¾Ð»ÑÐ½ÑÑ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ð¹, Ð°ÑÐºÐ¾ÑÐ±Ð¸Ð½Ð¾Ð²Ð¾Ð¹ ÐºÐ¸ÑÐ»Ð¾ÑÑ, ÐºÐ°ÑÐ¾ÑÐ¸Ð½Ð¾Ð¸Ð´Ð¾Ð² Ð¸ Î²-ÐºÐ°ÑÐ¾ÑÐ¸Ð½Ð°. ÐÑÐ¾Ð±ÑÐ°Ð½Ð½ÑÐ¹ ÑÐ¾ÑÑ ÑÐµÐºÐ¾Ð¼ÐµÐ½Ð´Ð¾Ð²Ð°Ð½ Ð´Ð»Ñ Ð¿Ð¾ÑÐ»ÐµÐ´ÑÑÑÐµÐ³Ð¾ Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ Ð² ÐºÐ°ÑÐµÑÑÐ²Ðµ Ð¸ÑÑÐ¾ÑÐ½Ð¸ÐºÐ° ÐÐÐ, Ð¾Ð±Ð»Ð°Ð´Ð°ÑÑÐ¸Ñ Ð¿Ð¾ÑÐµÐ½ÑÐ¸Ð°Ð»ÑÐ½ÑÐ¼Ð¸ Ð¾Ð½ÐºÐ¾Ð¿ÑÐ¾ÑÐµÐºÑÐ¾ÑÐ½ÑÐ¼Ð¸ ÑÐ²Ð¾Ð¹ÑÑÐ²Ð°Ð¼Ð¸.
description: 61 pages, 4 tables, 8 pictures The graduate qualification work on the topic âStudy of the content of chemical and biologically active substances used as natural oncoprotectors in root crops of the radish seed Raphanus Sativus L.â presents research results obtained both in the field of medical biotechnology and in the field of plant biochemistry. The first area of this research included the study of the antitumor activity of the Russian pharmacological drug called dioxadet, synthesized at the N.N.Petrov National Medical Research Center of Oncology (St. Petersburg). Experiments were conducted on a model of an ovarian cancer transplantable strain in rats. The criterion for evaluating the dioxadet effectiveness was reactive changes in cytomorphometric characteristics of rat ascitic fluid cancer cells. The experimental results confirmed the anticancerogenic effect of dioxadet. The second area of this research was a comparative study of the biochemical composition of different varieties of the radish seed Raphanus Sativus L. - a natural source of antioxidants. The modern gas-liquid chromatography method with mass spectrometry was used to study the metabolic composition of plant raw material. According to results obtained, variety radish seed Kirmiri contained the maximum amount of phenolic compounds, ascorbic acid, carotenoids and Î²-carotene. This variety could be recommended as a source of biologically active substances with potential oncoprotective properties for further study.