cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Discovery of benzamide-hydroxypyridinone hybrids as potent multi-targeting agents for the treatment of Alzheimer's disease
Creators: name: Jiang, Xiaoying
name: Guo, Jianan
name: Zhang, Changjun
name: Gu, Jinping
name: Zhou, Tao
name: Bai, Renren
name: Xie, Yuanyuan
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Hematology
subject: Virology

description: A novel class of benzamide-hydroxypyridinone (HPO) derivatives were innovatively designed, synthesised, and biologically evaluated as potential multitargeting candidates for the treatment of Alzheimer's disease (AD) through pharmacophores-merged approaches based on lead compounds 18d, benzyloxy phenyl analogs, and deferiprone (DFP). These hybrids possessed potent Monoamine oxidase B (MAO-B) inhibition as well as excellent iron chelation, with pFe3+ values ranging from 18.13 to 19.39. Among all the compounds, 8g exhibited the most potent selective MAO-B inhibitor (IC50 = 68.4 nM, SI = 213). Moreover, 8g showed favourable pharmacokinetic properties and had great potential to penetrate the BBB in silico and PAMPA-BBB assay. Molecular modelling showed that 8g could adopt an extended conformation and have more enhanced interactions with MAO-B than 18d. In vitro and in vivo assays demonstrated that 8g remarkably resisted Aβ-induced oxidation and ameliorated cognitive impairment induced by scopolamine. Taken collectively, these results suggest that compound 8g is a potential multifunctional candidate for anti-AD treatment.
Ferramenta da Terapia Breve Orientada para a Solução (TBOS): Escala de Avaliação de Suporte Social
Creators: name: Brandl, Edenilson
Publisher: name: Zenodo
Year: 2024
Subjects: Ferramenta da Terapia Breve Orientada para a Solução (TBOS)
Terapia Breve Orientada para a Solução (TBOS)
Escala de Avaliação de Suporte Social
Enciclopédia da Conscienciologia

description: Definologia: A escala de avaliação de suporte social é uma ferramenta da Terapia Breve Orientada para a Solução (TBOS) utilizada para mensurar o nível de suporte social percebido pelo paciente em diferentes áreas de sua vida, incluindo apoio emocional, instrumental, informativo e afetivo.
2024-10-29 Lingnan University - Credible science: Understanding and overcoming challenges
Creators: name: Feldman, Gilad
Publisher: name: OSF
Year: 2021

description: Do we know how to assess the credibility of information and scientific evidence? It’s a routine task we face in our everyday lives and in our work as scientists, and yet in recent years we’ve increasingly become aware of our limitations – we are not sure how and not very good at assessing credibility. This has immense implications, ranging from making simple decisions, to addressing urgent global challenges such as pandemics and climate change. In every step of the way our cognitive limitations, bounded rationality, and social influences hinder us in noticing, processing, searching, evaluating, interpreting, comparing, remembering, retrieving, and communicating information.

I will address these challenges from the perspective of experiments from the field of judgment and decision making, and social psychology. In these fields we are now coping with the immense task of understanding and addressing the growing crisis of misinformation and the increasing prevalence and impact of AI tools. Yet, in our very own academic circles we have yet to come to a consensus as a scientific community in how to best assess the credibility of scientific evidence, in how we should conduct and evaluate research. A recent example is surrounding the so-called “science crisis” identifying challenges regarding the replicability, reproducibility, theory, measurement, and sharing of scientific evidence. This led to a science reform movement calling for major overhaul in the way that we do science and the need for an implementation of “open science”, routinely evaluating science using scientific principles using “meta science”, and moving towards collaborative large-scale “team science”.

I will provide a brief overview of my understanding of these challenges, my changes to my own science process, and the research that I do that aims to improve on and overcome some of these challenges.
Inequality, Living Standards and the Social Wage During the 1980s
Creators: name: Raskall, Phil
name: Urquhart, Robert
Publisher: name: UNSW Sydney
Year: 1994
Subjects: Social Wage
Inequality
Living Standards
Australia

description: This report addresses the role of the social wage in maintaining the living standards of Australian households and mitigating the rise in inequality in the latter half of the 1980s. The results show the important role of social wage policies over the period and highlight the way in which Medicare and other health programs, education provisions and income transfers redistribute resources within and between groups in the population. Amongst other things, the results reported here highlight how the picture of living standards which emerges from studies focusing on trends in cash income only reveals only part of the whole story.
description: Study of Social and Economic Inequalities; SSEI Monograph No 3
Peter in Italy : compositional responses to place through an employment of musical topics
Creators: name: Longworth, Peter
Publisher: name: The University of St Andrews
Year: 2024
Subjects: Composition
Mimesis
Topic theory
Tuscany
Bells
Giovanni Pascoli
Giambattista Basile
Bergamo
Contemporary music

description: This body of work is informed by the composer’s experiences of, and interest in, specific places, with his wife’s native Italy a recurrent source of inspiration. The research explores this creative stimulus from different angles through a portfolio of eleven original compositions, ranging from solo works to orchestral pieces. Many of these respond to the sonic or physical landscapes of specific places, or to the sensations that are awakened by the composer’s memories of being in a certain location, often during a particular time of day. Other works are more indirect in their approach, engaging with places in a cultural context through the lens of literature or traditional melodies. These various types of engagement with place are united by the employment of topics: ‘musical signs [which] consist of a signifier (a certain disposition of musical dimensions) and a signified (a conventional stylistic unit, often but not always referential in quality)’ (Agawu, 1991, p.49). Rather than inventing new topics, the music harnesses the evocative capacity of a collection of pre-existing topics, from nocturnes and fanfares to different manifestations of the pastoral, in response to various place-informed stimuli. In the portfolio’s most pictorial works, imitations (drawn largely from transcriptions of field recordings) of bird- and insect-song, church bells, and vehicle noises constitute, moreover, examples of what musicologist Raymond Monelle termed ‘iconic topics’ through their ‘representation... of natural [and in this case, man-made] sounds’ (Monelle, 2006, p.28). That ‘topic’ derives from the Greek topos or ‘place’ is apposite given the nature of the research, and the submitted works may be heard as an exploration of this connection through their use of ‘musical places’ to suggest elements of physical, or remembered, ones.
title: saint Macaire d'Alexandrie
Creators: name: Centre De Recherches Historiques / Anthropologie Historique Du Long Moyen Âge
Publisher: name: EHESS (School for Advanced Studies in Social Sciences)
Year: 2019

description: Né en Alexandrie vers 309 ; se retira dans le désert de Nitrie, ami de saint Macaire l'Ancien, fut persécuté, comme lui, pour son zèle à combattre les ariens.
Agricultural transformation through wheat: An outcome evaluation of TAAT Wheat Compact’s Interventions in Sudan
Creators: name: Okoruwa, Victor
name: Zozo, Rachel
name: Kago, Kennedy
name: Atayi  Opaluwah
name: Lewis, Sabra
name: Zewdie Bishaw
name: Gizaw, Solomon
name: Chrys  Akem
Publisher: name: Gates Open Research
Year: 2024

description: This working paper evaluates the Technologies for African Agricultural Transformation (TAAT) Wheat Compact's interventions in Sudan, which aim to boost wheat production and achieve self-sufficiency. Key focus areas include addressing heat stress by introducing heat-tolerant wheat varieties, deploying technology through an Innovation Platform model, bulking wheat seeds for better access, and fostering partnerships among various stakeholders. Monitoring and evaluation (MEL) were crucial for assessing the program's impact.

Key outcomes include a record wheat production of 1.15 million tons in 2019/2020, increased yields of 4.9 tons per hectare, improved farmer incomes, and created over 113,000 jobs, surpassing the initial target of 45,000. Lessons learned emphasize the importance of market access, finance, stakeholder coordination, capacity development, and robust MEL for future success.

The paper concludes by recommending strategies to enhance program effectiveness and sustainability. It notes that while significant progress was made, ongoing improvements are essential to sustaining long-term impacts.
Income Poverty, Deprivation and Exclusion: A Comparative Study of Australia and Britain
Creators: name: Saunders, Peter
name: Adelman, Laura
Publisher: name: UNSW Sydney
Year: 2005

description: Poverty research has a long history in both Australia and Britain, but its influence on policy remains hostage to political priorities and ideology. This can partly be explained by the acknowledged limitations of defining poverty as low-income and measuring it using an income poverty line. This paper examines two new data sets that allow the income poverty profile to be compared with, and enriched by, the incidence of deprivation and social exclusion, measured using data that directly reflect experience. Although a degree of care must be applied when interpreting these new measures across countries, a validated poverty measure is developed that reflects both low-income and the experience of deprivation and exclusion. When results for the two countries are compared, they reveal stark differences between the alternative indicators. Britain has the higher income poverty rate, yet the incidence of both deprivation and exclusion are higher in Australia, while validated poverty is higher in Britain. The distributional profiles of deprivation and exclusion are shown to be very different in the two countries. These differences are explained by the very low incomes of low-income households in Britain, relative to other British households and relative to their Australian counterparts. In overall terms, the results suggest that the three groups facing the greatest risk in both countries are lone parents, single non-aged people and large (couple) families. This suggests that policies designed to improve low incomes would be targeted very differently from those aimed at alleviating deprivation or combating exclusion.
description: SPRC Discussion Paper; 141
Agricultural transformation through orange-fleshed sweetpotato: An outcome evaluation of TAAT OFSP Compact’s interventions in Uganda
Creators: name: Okoruwa, Victor
name: Zozo, Rachel
name: Kago, Kennedy
name: Atayi Opaluwah
name: Lewis, Sabra
name: Maru, Joyce
name: Gizaw, Solomon
name: Chyrs Akem
Publisher: name: Gates Open Research
Year: 2024

description: The TAAT Orange-fleshed Sweetpotato (OFSP) Compact in Uganda focuses on improving nutrition, creating jobs, and boosting rural economies by enhancing OFSP production. Uganda faces high levels of Vitamin A deficiency, particularly among children, and OFSP, which is rich in beta-carotene, provides a solution. The program builds on previous initiatives and collaborates with 74 public and private partners to ensure effective technology dissemination. Key interventions include outreach campaigns, climate-smart technologies like the Triple S method for planting material production, and tools to promote OFSP consumption among infants. Youth and women are trained in value addition, entrepreneurship, and silage production, creating employment opportunities.

The program has significantly increased OFSP productivity, improved food security, and facilitated 1,053 new agribusinesses. OFSP processing techniques have added an estimated US$10.1 million in production value, boosting incomes. Additionally, 10.3 million quality vines have been distributed to farmers. The program's success highlights the importance of communication, partnerships, and community engagement. Future efforts should expand the program's reach to benefit unemployed youth and improve livelihoods.
Supplementary document for Directional Dependent Magnetooptical Effect and Photonic Spin Hall Effect in Magnetic Weyl Semimetals based Photonic Crystal - 5985516.pdf
Creators: name: da, xia
name: Song, Qi
name: Ye, Huapeng
Publisher: name: Optica Publishing Group
Year: 2022
Subjects: Uncategorized

description: supplemental document
title: saint Cyriaque
Creators: name: Centre De Recherches Historiques / Anthropologie Historique Du Long Moyen Âge
Publisher: name: EHESS (School for Advanced Studies in Social Sciences)
Year: 2019

description: Saint légendaire qui indique à sainte Hélène comment retrouver les trois croix du Golgotha ; converti, il devient évêque de Jérusalem ; martyrisé sous Julien l'Apostat ; attribut : la vraie croix.
Motivos clássicos em Rosalía de Castro: notas de leitura
Creators: name: Fialho, Maria Do Céu
Publisher: name: Máthesis
Year: 2008

description: Aparentemente regionalista, a poesia de Rosalía de Castro enquadra-se no espírito da sua época, de valorização da dimensão de autoctonia e regionalidade. O seu cantar de matriz popular dá voz à injustiça social e à sombria sorte dos humildes, sensíveis amantes da sua terra e da sua casa, exilados pela necessidade de buscar trabalho. A escritora recorre expressivamente a referências da tradição lírica medieval, como é próprio do Romantismo e do contexto da afirmação galega. O seu conhecimento dos clássicos oferece-lhe recursos expressivos em Píndaro, Safo, Virgílio, Ovídio, para exprimir essa fragilidade da existência individual e social do homem, sob o signo da sombra - uma sombra existencial e peculiar da paisagem galega.
description: Máthesis, n. 17 (2008)
Why Do the Wives of Unemployed Men Have Such Low Employment Rates?
Creators: name: King, Anthony
name: Bradbury, Bruce
name: McHugh, Marilyn
Publisher: name: UNSW Sydney
Year: 1995
Subjects: Women
Employment Rates

description: The question of why women with partners receiving unemployment allowances have such low employment rates is addressed here with analysis of information from three data sources. These provide perspectives on different aspects of the question and also reflect an increasing intensity of focus. The first is the analysis of labour force data from the Australian Bureau of Statistics CABS) on unemployed men and their partners. The second examines a longitudinal dataset including couples where the man is receiving an unemployment allowance, which was constructed from DSS administrative data. The third source of information is an exploratory survey undertaken specifically for this study, involving personal interviews with 75 women whose partners were, or had recently been, receiving unemployment allowance.
description: Reports and Proceedings; 125
A predestinada peregrina: dos enganos do bosque aos desenganos do rio
Creators: name: Augusto, Sara
Publisher: name: Máthesis
Year: 2008

description: No quadro da literatura ficcional barroca, a narrativa alegórica produzida no âmbito religioso ganhou formas bem definidas, desenhando uma estrutura que conjugava o enredo agradável aos sentidos com uma utilidade moral. Depois do Predestinado Peregrino, de Alexandre de Gusmão, e do Peregrino da América, de Nuno Marques Pereira, a produção conventual, por mão de Soror Maria do Céu e Soror Madalena da Glória, recorreu intensamente à narrativa ficcional alegórica. Escolhendo personagens femininas como protagonistas, as novelas de Maria do Céu constroem universos onde as prefigurações da "alma humana" se debatem na fragilidade do seu percurso na terra antes de alcançarem o Céu. Neste quadro se coloca a novela Enganos do Bosque, Desenganos do Rio, com as suas duas partes editadas conjuntamente em 1741.
description: Máthesis, n. 17 (2008)
Presença de microplásticos em tecidos humanos e potenciais impactos à saúde_ um protocolo de revisão de escopo.pdf
Creators: name: Barcelos, Thainá
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 420203
subject: Environmental epidemiology

description: O objetivo desta revisão de escopo é entender a extensão e o tipo de evidência sobre a presença de microplásticos em amostras biológicas humanas e os potenciais impactos à saúde associados a essa presença em tecidos humanos.
title: sainte Agnès
Creators: name: Centre De Recherches Historiques / Anthropologie Historique Du Long Moyen Âge
Publisher: name: EHESS (School for Advanced Studies in Social Sciences)
Year: 2019

description: Vierge et martyre romaine ; première sainte à être dotée d'un attribut: l'agneau blanc couché à ses pieds ou minuscule dans le creux de sa main, un glaive, la palme du martyr, un rameau ou une couronne d'olivier, un bûcher en flammes.
Social Security in Selected East Asian Countries: An Annotated Bibliography
Creators: name: Encel, Diana
name: Sitsky, Lynn
Publisher: name: UNSW Sydney
Year: 1997
Subjects: Annotated Bibliography
Social security
South East Asia

description: Australia's involvement with East Asian countries has been increasing over recent times. The Social Policy Research Centre has collaborated with The Asia-Australia Institute in fostering an interest in issues of social policy in the region. This bibliography has taken as its focus one aspect, social security, in the following eleven East Asian countries: China, Hong Kong, Indonesia, Japan, Korea, Malaysia, the Philippines, Singapore, Sri Lanka, Taiwan and Thailand. The year 1980 was taken as our starting point. Social security is taken to be concerned with aspects of financial support for certain population groups in need of assistance. The topic overlaps with consideration of more general social welfare issues; however, items concerned with issues other than social security itself have not been included here except where they are inextricably interlocked with social security itself. Family support for the aged, for instance, is the subject of much research and a large literature, including discussions of the old-age security incentive for high fertility rates. Works on such topics are only included here where they also have specific mention of social security programs. The purpose of this bibliography is to gather together works written in English that are relatively easily accessible in Australia. Naturally, there is much published in journals and in languages of the individual countries that has not been included here. Readers are directed to consult also the page entitled 'Other Sources' following this Introduction. As an initial step in the preparation, on-line bibliographic searches were made on a number of databases. The resources of the SPRC library and other material held in the Centre were also used to identify further items for inclusion. The scope of the bibliography is defined by the keywords chosen which range widely over social security issues. Users with particular social security interests will gain from a careful reading of the keyword definitions.
description: Research Resource Series; No 13
Chemical constituents from the twigs and leaves of Picrasma quassioides
Creators: name: Zhou, Ya-Ling
name: Bi, De-Wen
name: Sun, Xiao-Rong
name: Pang, Wen-Hui
name: Li, Rui
name: Qiu, Xiong
name: Zhang, Rui-Han
name: Zhang, Xing-Jie
name: Li, Xiao-Li
name: Xiao, Wei-Lie
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Two new compounds, including a norsesquiterpenoid, annuionone H (1), and a quassinoid, picraqualide G (2), along with eleven known compounds (3–13), were isolated from the twigs and leaves of Picrasma quassioides. Comprehensive spectroscopic analyses and NMR calculation with DP4+ analysis were used to identify their structures. Moreover, of all these compounds, compound 4 showed a week inhibition rate in the anti-inflammatory screening results against mouse macrophage J774A.1 cell.
A influência da comédia clássica em Ulissipo de Jorge Ferreira de Vasconcelos
Creators: name: Toipa, Helena Costa
Publisher: name: Máthesis
Year: 2007

description: No século XVI, no período do Renascimento, o escritor português Jorge Ferreira de Vasconcelos compôs as comédias Eufrósina, Ulissipo e Aulegrafia, nas quais regista a intluência dos modelos literários e sociais de seu tempo, mas também a dos autores clássicos Plauto e Terêncio. Das suas comédias, a que mais se aproxima do modelo clássico é Ulissipo.
description: Máthesis, n. 16 (2007)
Protection against SARS-CoV-2 Omicron BA.4/5 variant following booster vaccination or breakthrough infection in the UK.
Creators: name: Wei, Jia
name: Matthews, Philippa C
name: Stoesser, Nicole
name: Newton, John N
name: Diamond, Ian
name: Studley, Ruth
name: Taylor, Nick
name: Bell, John I
name: Farrar, Jeremy
name: Kolenchery, Jaison
name: Marsden, Brian D
name: Hoosdally, Sarah
name: Jones, E Yvonne
name: Stuart, David I
name: Crook, Derrick W
name: Peto, Tim EA
name: Walker, A Sarah
name: Pouwels, Koen B
name: Eyre, David W
name: team, The COVID-19 Infection Survey
Publisher: name: The Francis Crick Institute
Year: 2023
Subjects: classificationCode: Genetics & Genomics
subject: Genetics & Genomics
classificationCode: Infectious Disease
subject: Infectious Disease
classificationCode: Immunology
subject: Immunology
subject: FOS: Clinical medicine

description: Following primary SARS-CoV-2 vaccination, whether boosters or breakthrough infections provide greater protection against SARS-CoV-2 infection is incompletely understood. Here we investigated SARS-CoV-2 antibody correlates of protection against new Omicron BA.4/5 (re-)infections and anti-spike IgG antibody trajectories after a third/booster vaccination or breakthrough infection following second vaccination in 154,149 adults ≥18 y from the United Kingdom general population. Higher antibody levels were associated with increased protection against Omicron BA.4/5 infection and breakthrough infections were associated with higher levels of protection at any given antibody level than boosters. Breakthrough infections generated similar antibody levels to boosters, and the subsequent antibody declines were slightly slower than after boosters. Together our findings show breakthrough infection provides longer-lasting protection against further infections than booster vaccinations. Our findings, considered alongside the risks of severe infection and long-term consequences of infection, have important implications for vaccine policy.
Exploring motivating factors for soil protection measures by farmers in the Spanish region of Guadalajara: A Q-Methodology approach
Creators: name: Lunar-Koch, Ernesto José
Publisher: name: Zenodo
Year: 2024

description: Soil health is crucial for agricultural productivity and environmental sustainability, yet farmers' adoption of soil protection practices varies widely. This study focuses on understanding the motivations behind soil management decisions among farmers in Guadalajara, Spain, using the Qmethodology. The research identifies three archetypes of farmers: "The Soil Considered," who prioritize long-term soil health; "The Economic Individualist," who focuses on immediate economic gains; and "The Contemporary Minded," who balance economic viability with ecological responsibility. Through semi-structured interviews and Q-sorting, the study reveals that economic pressures, skepticism towards external advice, and bureaucratic challenges are significant barriers to adopting sustainable practices. The findings suggest that current policy measures, particularly those related to the Common Agricultural Policy, are inadequate in addressing these challenges. Farmers expressed a preference for compensation in addition to fair market prices rather than traditional subsidies. The study concludes that a wider approach in agricultural policies, which includes expanding Agri-Environmental Schemes and reducing bureaucratic burdens, could better support soil conservation efforts. This research provides valuable insights for policymakers aiming to enhance agricultural resilience and sustainability, though further investigation is needed to address the economic and social barriers hindering broader adoption of sustainable practices.
Social Policy and the Challenges of Social Change, Proceedings of the National Social Policy Conference, Sydney, 5-7 July 1995, Volume 1
Creators: name: Saunders, Peter
name: Shaver, Sheila
Publisher: name: UNSW Sydney
Year: 1995
Subjects: Work
Welfare
Social Inequality
Economic Inequality
Families
Community Services
Poverty

description: This year's conference was divided into broad social policy themes: Work and Welfare; Social and Economic Inequality; Family, the Life Course and the State; Community Services; Citizenship and the Mixed Economy of Welfare; and an Open Section which covered a variety of themes not included in the above categories. This volume of papers from the Conference includes the keynote address, the first of the plenary papers and thirteen contributed papers. There is no connecting theme to the contributed papers which are in alphabetical order by author within each volume.
description: Reports and Proceedings; 122
Phonetish-Phonologische Analyse Deutscher und Portugiesischer Vokale
Creators: name: Espírito-Santo, Francisco
Publisher: name: Máthesis
Year: 2009

description: Ziel dieser Arbeit ist es, Deutsch und Europäisches Portugie-sisch phonetisch-phonologisch zu vergleichen, indem jeweils eine der Sprachen als Zielsprache betrachtet wird. Berücksichtigt werden systemische, segmentale, vokalische Erscheinungen und Merkmale in den jeweiligen Vokalsubsystemen,die Interferenz bzw. Fehler bei Lernenden hervorrufen können. Auch intralinguistische Kontexte (wie phonotaktische Regeln oder Variation) werden mit einbezogen.
description: Máthesis, n. 18 (2009)
title: LEMI-424 Magnetotelluric Station Field Operations - Geoscience Australia Standard Operating Procedure
Creators: name: A., Hitchman
name: J., Duan
name: D., Kyi
name: W., Jiang
name: P., Maher
Publisher: name: Commonwealth of Australia (Geoscience Australia)
Year: 2024
Subjects: subject: magnetotellurics
subject: AusLAMP
subject: geophysics
subject: technical standards
subject: Electrical and electromagnetic methods in geophysics
subject: Published_External

description: This document describes Geoscience Australia’s standard operating procedure for acquiring long-period magnetotelluric (MT) data using equipment supplied by LEMI LLC. It is current as at April 2024. Users should check periodically for updated versions.
The procedure is based on the use of the LEMI-424 magnetotelluric station, comprising:·     LEMI-424 data logger·     LEMI-039 3-component analog magnetometer and cable·     LEMI-701 electrodes·     GPS receiver·     electric-line interface box
Geoscience Australia supplements this equipment with the addition of:·     a Pelican equipment box to hold and transport the equipment·     an acrylic housing to protect the LEMI-039 magnetometer·     four 50 m electrode cables·     a brass earth stake and cable·     a 12 V battery·     a solar panel
title: saint Léonard
Creators: name: Centre De Recherches Historiques / Anthropologie Historique Du Long Moyen Âge
Publisher: name: EHESS (School for Advanced Studies in Social Sciences)
Year: 2019

description: Filleul de Clovis, converti après la bataille de Tolbiac ; ermite dans le Limousin, disciple de saint Rémi et fondateur du monastère de Saint-Léonard-de-Noblat ; mort en 560 ; représenté en moine ou diacre il porte des chaînes brisées.
Trastuzumab biosimilar HLX02 versus reference trastuzumab in patients with recurrent or metastatic HER2-positive breast cancer: a model-based economic evaluation for China
Creators: name: Deng, Weishang
name: Hu, Jia
name: Li, Mengting
name: Yang, Sensen
name: Xie, Zeyu
name: Chen, Jisheng
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: HLX02 is a newly marketed trastuzumab biosimilar in China, but whether its price reflects a potential benefit in terms of its value remains unclear. In addition, the development of biosimilars in China is just beginning, and the state encourages health economic evaluation of newly marketed biosimilars. Based on the previously published randomized controlled trial data, a Markov model was used to perform health economic evaluation of HLX02 and trastuzumab in the treatment of HER2-positive recurrent or metastatic breast cancer, calculate quality-adjusted life years (QALYs) and incremental cost-effectiveness ratio (ICER), and evaluate the robustness of the model with sensitivity analysis. The model results showed that the 5-year mortality rate was 84.4% in the HLX02 group, while the mortality rate was 91.2% in the trastuzumab group. When without accounting for the cost of second-line treatment, patients treated with HLX02 had an increased life expectancy of 0.138 QALYs and a $421.11 lower cost compared with patients in the trastuzumab group, with an ICER value of -$3,051.52/QALY. At the willingness-to-pay threshold of $37,653/QALY in China, HLX02 is more cost-effective than trastuzumab. However, the relevant systems for the regulation of biosimilars still need to be improved. Metastatic HER-2 positive breast cancer poses a considerable cost to society due to limitations in health care resources. HLX02 is the first trastuzumab biosimilar produced in China and evaluated worldwide, and its emergence has opened the door to trastuzumab biosimilars in China. Although HLX02 has been shown to be clinically equivalent to the original drug in the treatment of metastatic HER2-positive breast cancer, it remains unclear whether its price reflects the potential benefit in terms of its value. In addition, the development of biosimilars in China is just beginning, and the state encourages health economic evaluation of newly marketed biosimilars. Based on the results of Markov model, at the willingness-to-pay threshold of $37,653/QALY in China, HLX02 is more cost-effective than trastuzumab under the condition of equivalent efficacy and safety. However, it remains challenging to adjust the development of the regulation of biosimilars, such as the price difference between biosimilars and original drugs.
Benchmarks and Other Approaches to Planning Community Support Services: A Review of International Experience
Creators: name: Fine, Michael
name: Graham, Sara
name: Webb, Adrian
Publisher: name: UNSW Sydney
Year: 1991
Subjects: Community Support Services

description: The research presented here began with an apparently simple question: would it be feasible to establish 'benchmarks' measuring the adequacy of community support services, and if so would devices of this kind be desirable? The experience of other countries was expected to provide practical information about how national standards have been set elsewhere and the way such standards have contributed to the planning process. In the event the question was not so simple, and the consideration of benchmarks led the researchers into examining fundamental issues in community service provision. Conceptual issues are the subject of Chapter Two, in a discussion of the complex relations between needs, resources and planning. Chapter Three examines the Home and Community Care program and the particular issues of service planning and monitoring it has raised. A review of overseas experience soon led the researchers to question the efficacy of centrally determined measures of adequacy and equity in service development. Chapter Four provides a systematic review of the planning modes in operation elsewhere. The authors conclude with a discussion of alternative strategies for the development of planning of community support services.
description: Reports and Proceedings; 94
Unravelling slab δ34S compositions from in-situ sulphide δ34S studies of high-pressure metamorphic rocks
Creators: name: Li, Ji-Lei
name: Klemd, Reiner
name: Huang, Gao-Feng
name: Ague, Jay J.
name: Gao, Jun
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Space Science
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Sulphur is of particular importance in the subduction zone system, as it is thought to be intimately related to the arc redox state and metallogenesis above the slab. Knowing the sulphur isotope compositions of the subducted slab, and identifying the δ34S variations between the pre-subduction oceanic lithosphere and its high-pressure (HP) equivalents is of great importance for understanding the sulphur behaviour in subduction zones and the long-term sulphur recycling of the Earth. In this study, we undertook secondary ion mass spectroscopy (SIMS) in-situ δ34S analyses of sulphides from metasediments, mafic blueschists/eclogites, and ultramafic slab serpentinites from the Southwestern Tianshan HP–UHP metamorphic belt, which represents one of the deepest fossil subduction zones on Earth. By integrating the in-situ δ34S compositions of sulphides studied here and those reported from worldwide HP–UHP metamorphic terranes, we found that prograde to peak metamorphic sulphides of metasediments, metabasites/metagabbros, and slab HP serpentinites have δ34S values ranging from –33 to –6‰, –4 to +4‰, and +2 to +18‰, respectively. However, retrograde metasomatism of HP rocks during exhumation may alter the δ34S compositions of sulphides. The integrated dataset proposes that sulphides in subducting slab sequences retain their protolith’s δ34S signatures during HP metamorphism. The δ34S inheritance indicates that no large isotope fractionation is expected to occur in subduction zones. It further suggests that evaluations of slab subduction effects on the δ34S signature of arc magmatism and the deep mantle should consider pre-subduction processes such as ridge geodynamic setting and hydrothermal alteration.
title: saint Barnabé
Creators: name: Centre De Recherches Historiques / Anthropologie Historique Du Long Moyen Âge
Publisher: name: EHESS (School for Advanced Studies in Social Sciences)
Year: 2019

description: Ne faisant pas partie des douze apôtres, l'Église lui en attribue le titre pour sa diffusion de la parole du Christ ; cousin de Marc l'évangéliste ; il accompagne Paul de Tarse dans ses premières missions chez les païens ; martyrisé près de Salamine de Chypre vers 63 ; attributs : les pierres de sa lapidation et le livre de l'évangile de saint Matthieu.
"Aquí" e "lá": a construção teatral de uma utopia em aves
Creators: name: Silva, Maria De Fátima
Publisher: name: Máthesis
Year: 2007

description: Dedicado ao tema da utopia, este estudo privilegia As aves de Aristófanes, procurando identificar, na execução cómica do tema, sinais de técnicas palpáveis, literárias e cénicas.
description: Máthesis, n. 16 (2007)
O jovem apaixonado nas comédias de Jorge Ferreira de Vasconcelos
Creators: name: Toipa, Helena Costa
Publisher: name: Máthesis
Year: 2008

description: As comédias de Jorge Ferreira de Vasconcelos põem em cena, entre muitas personagens, duas espécies de jovens rapazes apaixonados: uns mais idealistas e verdadeiramente cativos do amor; outros mais pragmáticos e mais superficiais. O nosso objectivo é apresentar algumas características desses dois grupos de amorosos.
description: Máthesis, n. 17 (2008)
title: Peak shaving at system level with a large district heating substation using deep learning forecasting models
Creators: name: Trabert, Ulrich
name: Pag, Felix
name: Orozaliev, Janybek
name: Jordan, Ulrike
name: Vajen, Klaus
Publisher: name: Universität Kassel
Year: 2024
Subjects: subject: forecasting
subject: machine learning
subject: incremental learning
subject: large district heating substation
subject: thermal storage
subject: peak shaving
subject: 333
subject: 620
subject: Prognose
subject: Maschinelles Lernen
subject: Inkrementelles Lernen
subject: Fernwärmeversorgung
subject: Wärmespeicherung
subject: Lastspitzenkappung

description: Gefördert im Rahmen des Projekts DEAL
title: sainte Barbe
Creators: name: Centre De Recherches Historiques / Anthropologie Historique Du Long Moyen Âge
Publisher: name: EHESS (School for Advanced Studies in Social Sciences)
Year: 2019

description: Vierge et martyre à Nicomédie, en 235 ; représentée avec un ou plusieurs attributs : une tour à trois fenêtres, un éclair, un livre, une plume de paon, son père foulé à ses pieds, un ciboire surmontée d'une hostie, un canon ou un boulet de canon.
title: Fiche Module CESU "L'usage des données spatiales en communication scientifique"
Creators: name: LabexMed
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: L'usage des données spatiales en communication scientifique.
description: created: 2014-2015
title: saint Antonin
Creators: name: Centre De Recherches Historiques / Anthropologie Historique Du Long Moyen Âge
Publisher: name: EHESS (School for Advanced Studies in Social Sciences)
Year: 2019

description: Moine dominicain, surnommé antonin des conseils ; archevêque de Florence en 1446 ; attributs : la balance dont les deux plateaux sont chargés d'une corbeille de fruits et d'un feuillet de papier ou une bourse d'où s'échappent les pièces de monnaie.
Additional file 1 of Development of optimal steam explosion pretreatment and highly effective cell factory for bioconversion of grain vinegar residue to butanol
Creators: name: Xia, Menglei
name: Peng, Mingmeng
name: Xue, Danni
name: Cheng, Yang
name: Li, Caixia
name: Wang, Di
name: Lu, Kai
name: Zheng, Yu
name: Xia, Ting
name: song, Jia
name: Wang, Min
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified

description: Additional file 1. The detailed data analysis procedure of spearman correlation, univariate and multivariable GAM.
Reflexiões em torno de "dicionário" e léxico(s)
Creators: name: Gil, Isabel
Publisher: name: Máthesis
Year: 2009

description: Este artigo apresenta uma reflexão sobre as práticas lexicográfica e terminográfica e seus desenvolvimentos, tomando como ponto de partida os conceitos de ‘dicionário’ e ‘definição’.
description: Máthesis, n. 18 (2009)
Entretien auprès de Mahmud Ahmad al-Siyah, natif de Mafraq, à propos de la rue Ali Abdiyeh
Creators: name: al-Siyah, Mahmud
name: Anass Al-Amush (Enquêteur)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Source: http://www.calames.abes.fr/pub/ms/FileId-3139
description: Coverage: Mafraq, Jordanie
Algumas considerações sobre línguas de especialidade e seus processos lexicogénicos (parte II)
Creators: name: Gil, Isabel Teresa Morais
Publisher: name: Máthesis
Year: 2007

description: O presente texto, que constitui a segunda parte do artigo com o título em epígrafe, tem por objectivo descrever os mecanismos lexicogenéticos mais relevantes nas línguas de especialidade: de entre alguns processos de formação de palavras, destaca-se o de lexicalização ou composição sintagmática, dada a sua elevada recorrência. São analisados ainda outros processos frequentes, tais como a criação lexical por eponímia ou por empréstimo. Finalmente, apresentam-se as conclusões.
description: Máthesis, n. 16 (2007)
Chemical epigenetic modifiers enhance the production of immunosuppressants from the endophytic fungus Aspergillus fumigatus isolated from Cynodon dactylon
Creators: name: Zhang, Wenfang
name: Li, Jinyuan
name: Wei, Chengwen
name: Deng, Xiaoling
name: Xu, Jing
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: Chemical epigenetic modifiers applied on a plant endophytic fungus Aspergillus fumigatus isolated from a healthy stem of terrestrial plant Cynodon dactylon, significantly changed of metabolic profile and resulted in the isolation of nineteen compounds, including ten alkaloids (1–10), six polyketides (11–16), and three benzene derivatives (17–19). This is the first report of 14, 18 and 19 being isolated from this fungal species. And compound 14 was known as a synthetic product and isolated as a natural product for the first time. HPLC profiles of the control and treated samples indicated that compounds 11, 16, 18 are belonged to the newly induced secondary metabolites. Their structures were elucidated on the basis of extensive NMR spectroscopic and mass spectrometric analyses. The immunosuppressive and cytotoxic activities of all isolated compounds were evaluated.
Temas clássicos na obra de Afonso X: Cantigas de Santa Maria e Cantigas de Amor
Creators: name: Ferreira, José Ribeiro
Publisher: name: Máthesis
Year: 2008

description: Este trabalho procura estudar a presença da Grécia e de Roma nas Cantigas de Santa Maria e nas Cantigas de Amor de Afonso X. Depois de uma análise e listagem de todas as ocorrências, talvez se possa concluir pela quase inexistência de presença dos temas clássicos na obra em galaico-português de Afonso X. Apenas figuras históricas, com ligação positiva ou negativa com o cristianismo, nas Cantigas de Santa Maria, e uma referência a Páris nas Cantigas de Amor, precisamente para sublinhar o poder de Eros.
description: Máthesis, n. 17 (2008)
Additional file 2 of Development of optimal steam explosion pretreatment and highly effective cell factory for bioconversion of grain vinegar residue to butanol
Creators: name: Xia, Menglei
name: Peng, Mingmeng
name: Xue, Danni
name: Cheng, Yang
name: Li, Caixia
name: Wang, Di
name: Lu, Kai
name: Zheng, Yu
name: Xia, Ting
name: song, Jia
name: Wang, Min
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified

description: Additional file 2. The detailed model derivation process for enzymolysis kinetic equation.
Additional file 3 of Development of optimal steam explosion pretreatment and highly effective cell factory for bioconversion of grain vinegar residue to butanol
Creators: name: Xia, Menglei
name: Peng, Mingmeng
name: Xue, Danni
name: Cheng, Yang
name: Li, Caixia
name: Wang, Di
name: Lu, Kai
name: Zheng, Yu
name: Xia, Ting
name: song, Jia
name: Wang, Min
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified

description: Additional file 3. The concrete process of the model fitting and the result evaluation for Eq. 2.
One-step constructing of underwater superoleophobic bed for highly efficient oil-in-water emulsions separation
Creators: name: Niu, Zhenhua
name: Luo, Wenjia
name: Liu, Weimin
name: Sun, Qing
name: Mu, Peng
name: Li, Jian
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Molecular Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: The efficient separation of emulsified oily wastewater is urgently needed and remains a worldwide challenge. However, the preparation of underwater superoleophobic materials still suffer from complicated process control, special equipment and expensive reagents, which further restricts the large-scale application of such materials. Herein, one-step constructing of underwater superoleophobic beds is introduced for highly efficient gravity-directed separation of various oil-in-water emulsions. Importantly, this study simplifies the fabrication process of underwater superoleophobic materials. It's worth noting that the strategy can achieve the effective separation of a range of oil-in-water emulsions by only requires simple accumulation of hydrophilic materials. More importantly, the underwater superoleophobic sandwich-structured beds still maintain the separation efficiency more than 99.2% after 10 cycles. In addition, this strategy is suitable for a variety of hydrophilic materials, which provides new perspectives for fabrication of novel oil-water emulsion-separating materials. One-step constructing of underwater superoleophobic bed was used for high efficiency separation of oil-in-water emulsions.
Additional file 4 of Development of optimal steam explosion pretreatment and highly effective cell factory for bioconversion of grain vinegar residue to butanol
Creators: name: Xia, Menglei
name: Peng, Mingmeng
name: Xue, Danni
name: Cheng, Yang
name: Li, Caixia
name: Wang, Di
name: Lu, Kai
name: Zheng, Yu
name: Xia, Ting
name: song, Jia
name: Wang, Min
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified

description: Additional file 4. The N2 adsorption in data in detailed.
À mesa com Grão Vasco: para o estudo da alimentação no século XVI
Creators: name: Braga, Isabel M. R. Mendes Drumond
Publisher: name: Máthesis
Year: 2007

description: Partindo de documentos escritos, nomeadamente livros de receitas, cadernos de ucharia, processos inquisitoriais e legislação diversa, passando por fontes iconográficas e, mais raramente, pelos testemunhos da arqueologia, procuramos dar conta do modo como se preparavam e se tomavam as refeições durante o século XVI.
description: Máthesis, n. 16 (2007)
Additional file 1 of Economic outcomes predicted by diversity in cities
Creators: name: Chong, Shi Kai
name: Bahrami, Mohsen
name: Chen, Hao
name: Balcisoy, Selim
name: Bozkaya, Burcin
name: Pentland, Alex ‘Sandy’
Publisher: name: figshare
Year: 2020
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Marine Biology
subject: Science Policy

description: Supplementary information (PDF 8.2 MB)
ДУТОР ЧОЛҒУСИ ТАРИХИГА БИР НАЗАР
Creators: name: Ҳайдаралиева, Дурдона
Publisher: name: Zenodo
Year: 2024

description: Мазкур мақолада халқимиз мусиқий меъросидан жой олган    дутор  чолғуси,  унинг  ижрочилик  услублари    тарихи,  мусиқа ижрочилиги  тарихий асослари ҳақида фикр-мулоҳазалар юритилади.