cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Virion-Associated Vpr Alleviates a Postintegration Block to HIV-1 Infection of Dendritic Cells
Creators: name: Swanstrom, Ronald I.
name: Ettinger, Chelsea R.
name: Emery, Ann
name: Gummuluru, Suryaram
name: Akiyama, Hisashi
name: Agosto, Luis M.
name: Miller, Caitlin M.
name: Henderson, Andrew J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: ABSTRACT Viral protein R (Vpr) is an HIV-1 accessory protein whose function remains poorly understood. In this report, we sought to determine the requirement of Vpr for facilitating HIV-1 infection of monocyte-derived dendritic cells (MDDCs), one of the first cell types to encounter virus in the peripheral mucosal tissues. In this report, we characterize a significant restriction of Vpr-deficient virus replication and spread in MDDCs alone and in cell-to-cell spread in MDDC-CD4 + T cell cocultures. This restriction of HIV-1 replication in MDDCs was observed in a single round of virus replication and was rescued by the expression of Vpr in trans in the incoming virion. Interestingly, infections of MDDCs with viruses that encode Vpr mutants unable to interact with either the DCAF1/DDB1 E3 ubiquitin ligase complex or a host factor hypothesized to be targeted for degradation by Vpr also displayed a significant replication defect. While the extent of proviral integration in HIV-1-infected MDDCs was unaffected by the absence of Vpr, the transcriptional activity of the viral long terminal repeat (LTR) from Vpr-deficient proviruses was significantly reduced. Together, these results characterize a novel postintegration restriction of HIV-1 replication in MDDCs and show that the interaction of Vpr with the DCAF1/DDB1 E3 ubiquitin ligase complex and the yet-to-be-identified host factor might alleviate this restriction by inducing transcription from the viral LTR. Taken together, these findings identify a robust in vitro cell culture system that is amenable to addressing mechanisms underlying Vpr-mediated enhancement of HIV-1 replication. IMPORTANCE Despite decades of work, the function of the HIV-1 protein Vpr remains poorly understood, primarily due to the lack of an in vitro cell culture system that demonstrates a deficit in replication upon infection with viruses in the absence of Vpr. In this report, we describe a novel cell infection system that utilizes primary human dendritic cells, which display a robust decrease in viral replication upon infection with Vpr-deficient HIV-1. We show that this replication difference occurs in a single round of infection and is due to decreased transcriptional output from the integrated viral genome. Viral transcription could be rescued by virion-associated Vpr. Using mutational analysis, we show that domains of Vpr involved in binding to the DCAF1/DDB1/E3 ubiquitin ligase complex and prevention of cell cycle progression into mitosis are required for LTR-mediated viral expression, suggesting that the evolutionarily conserved G 2 cell cycle arrest function of Vpr is essential for HIV-1 replication.
Additional file 1 of Family doctors’ attitudes toward peer support programs for type 2 diabetes and/or coronary artery disease: an exploratory survey among German practitioners
Creators: name: Majjouti, K.
name: Küppers, L.
name: Thielmann, A.
name: Redaélli, M.
name: Vitinius, F.
name: Funke, C.
name: van der Arend, I.
name: Pilic, L.
name: Hessbrügge, M.
name: Stock, S.
name: Weltermann, B.
name: Wild, D.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Ecology
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1: Table S1. Important aspects before recommending a PSP; “I am most likely to recommend the programme if…”. Table S2. What should be considered as most important in the composition of PSGs?. Table S3. PSG composition regarding organisational, medical and social factors. Table S4. Key characteristics of PSG-L. Table S5. Additional information FDs would like to have about the PSPs: Freetext answers (N = 90). Supplementary Table S6. Survey.
title: NeurOscientific Workflow Assistance (NOWA)
Creators: name: Arendt, Thorsten
name: Brand, Ortrun
name: Krippes, Christian
name: Gabriel, Andreas
name: Valsecchi, Matteo
name: Helf, Clemens
name: Gegenfurtner, Karl R.
name: Schütz, Alexander C.
Publisher: name: Philipps-Universität Marburg
Year: 2019
Subjects: subject: Verbund
subject: Psychology
subject: FOS: Psychology
subject: Psychologie
subject: Infrastruktur
subject: Kooperation
subject: Forschungsdaten
subject: Neurowissenschaften

description: In dem Infrastrukturprojekt NOWA (NeurOscientific Workflow Assistance) des von der DFG geförderten SFB/TRR 135 "Kardinale Mechanismen der Wahrnehmung: Prädiktion, Bewertung, Kategorisierung" werden Werkzeuge für die gemeinsame Nutzung von Forschungsdaten entwickelt. Um die Reproduzierbarkeit aller Schritte im Lebenszyklus einer wissenschaftlichen Studie zu verbessern – d.h. von der Planung bis zur Veröffentlichung von Forschungsdaten – zielt NOWA darauf ab, einen organisatorischen und technologischen Rahmen zu schaffen, der die Arbeitsabläufe entlang des gesamten Forschungsdatenlebenszyklus unterstützt. Ziel ist es, Forschungsdaten von Beginn an innerhalb der Arbeitsgruppen und des SFB zu teilen und sie zum Zeitpunkt der Veröffentlichung der Ergebnisse "auf Knopfdruck" öffentlich zugänglich zu machen. Die geplante Workflow-Unterstützung realisiert sich in einer Reihe von Leitlinien für das Forschungsdatenmanagement, die einerseits durch Sensibilisierung, Support und Schulung und andererseits durch eine kohärente Sammlung von Datenverarbeitungswerkzeugen umgesetzt werden. Das Poster präsentiert den Status Quo des INF-Projekts sowie die aktuelle prototypische Implementierung des digitalen Assistenzsystems.
description: - CRC/TRR 135 1 - NOWA: Aims and objectives 1 - Analytical part: Data Management Plans and Workflow Evaluation 1 - Technical part: A Software Toolset for Workflow Assistance 1 - Further Working Packages 1 - Long Term Perspective 1
Experimental Tests of Particle Flow Calorimetry
Creators: name: Sefkow, Felix
name: White, Andy
name: Kawagoe, Kiyotomo
name: Pöschl, Roman
name: Repond, José
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Precision physics at future colliders requires highly granular calorimeters to support the Particle Flow Approach for event reconstruction. This article presents a review of about 10 - 15 years of R\&D, mainly conducted within the CALICE collaboration, for this novel type of detector. The performance of large scale prototypes in beam tests validate the technical concept of particle flow calorimeters. The comparison of test beam data with simulation, of e.g.\ hadronic showers, supports full detector studies and gives deeper insight into the structure of hadronic cascades than was possible previously.
description: 55 pages, 83 figures, to appear in Reviews of Modern physics
A Simple Method for the Size Controlled Synthesis of Stable Oligomeric Clusters of Gold Nanoparticles under Ambient Conditions
Creators: name: Koklic, Tilen
name: Smithies, Oliver
name: Lawrence, Marlon
name: Testen, Anze
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Reducing dilute aqueous HAuCl4 with sodium thiocyanate (NaSCN) under alkaline conditions produces 2 to 3 nm diameter nanoparticles. Stable grape-like oligomeric clusters of these yellow nanoparticles of narrow size distribution are synthesized under ambient conditions via two methods. The delay-time method controls the number of subunits in the oligoclusters by varying the time between the addition of HAuCl4 to alkaline solution and the subsequent addition of reducing agent, NaSCN. The yellow oligoclusters produced range in size from ~3 to ~25 nm. This size range can be further extended by an add-on method utilizing hydroxylated gold chloride (Na+[Au(OH4-x)Clx]-) to auto-catalytically increase the number of subunits in the as-synthesized oligocluster nanoparticles, providing a total range of 3 nm to 70 nm. The crude oligocluster preparations display narrow size distributions and do not require further fractionation for most purposes. The oligoclusters formed can be concentrated >300 fold without aggregation and the crude reaction mixtures remain stable for weeks without further processing. Because these oligomeric clusters can be concentrated before derivatization they allow expensive derivatizing agents to be used economically. In addition, we present two models by which predictions of particle size can be made with great accuracy.
Executing Analysis Workflows at Scale with Coffea+Dask+TaskVine
Creators: name: Lopez, Benjamin Tovar
Publisher: name: Zenodo
Year: 2023

description: During this talk I will present our experiences executing analysis workflows on thousands of cores. We use TaskVine, a general-purpose task scheduler for large scale data intensive dynamic python applications, to execute the task graph generated by Coffea+Dask. As task data becomes available, TaskVine adapts the cores and memory allocated to maximize throughput and minimize retries. Additionally, TaskVine tries to minimize data movement by temporarily and aggressively caching data at the compute nodes. TaskVine executes these workflows without a previous setup in the compute nodes, as it dynamically delivers the dependencies using conda-based environment file.
Oedera hirta Thunberg 1800
Creators: name: Bergh, Nicola G.
name: Bentley, Joanne
name: Verboom, George Anthony
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Asterales
Asteraceae
Oedera
Oedera hirta

description: 17. Oedera hirta Thunberg (1800b: 169).
Type: SOUTH AFRICA, “Cap.”, Thunberg s.n., Thunberg Herb. No. 133625 (UPS-THUNB holotype).
description: Published as part of Bergh, Nicola G., Bentley, Joanne & Verboom, George Anthony, 2018, Classification of the Relhania generic group (Asteraceae, Gnaphalieae) revisited using molecular phylogenetic analysis, pp. 101-132 in Phytotaxa 344 (2) on page 122, DOI: 10.11646/phytotaxa.344.2.1, http://zenodo.org/record/13719571
title: IL-17 serum levels in psoriatic arthritis: Is there a correlation in early stages of freshly diagnosed Psoriasis Arthritis?
Creators: name: Becker-Capeller, Detlef
name: El-Nawab-Becker, Soham
name: Niggemann, Hiltrud
name: Krieger, Thorsten
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Background: Psoriasis (PsO) is a chronic inflammatory disease associated with other systemic disorders like cardiovascular diseases, metabolic syndromes and arthritis associated with tendonitis. Previously we could demonstrate in freshly diagnosed psoriatic patients Ultrasonic (US) and/or power[for full text, please go to the a.m. URL]
description: 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Architectural Photovoltaic Application
Creators: name: Haghighi, Zoheir
Publisher: name: A+BE | Architecture and the Built Environment
Year: 2022

description: The urgency to use renewable technologies within the built environment results in new interpretations of and approaches to Architecture. New building regulations, together with international pledges for addressing climate change, made the implications of photovoltaic systems (aka ‘solar panels’) in the buildings more crucial than ever. Moreover, the current mainstream of placing PV systems on the roof and façade of buildings is neither aesthetically appealing nor technically efficient and consequently not a sustainable, long-term, and reliable approach. In response to this issue, the concept of Integration is introduced as an alternative to this approach. This research suggests the notion of Architectural Photovoltaic Application (APA) in response to the various shortcomings of the Integration, with its current definitions, for being adapted to different architectural styles and approaches. APA can be defined as an approach in which PV technologies are meant to be sources of on-site renewable energy and considered a part of building services that is also incorporated to the building anatomy through the design process. Through APA, PV systems do not need to play a role in the building construction, instead these systems are fully accommodated by Architects in the design process as another element of the building service.
description: A+BE | Architecture and the Built Environment, No. 20 (2022): Architectural Photovoltaic Application
Optomechanical Entanglement under Pulse Drive
Creators: name: Lin, Qing
name: He, Bing
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We report a study of optomechanical entanglement under the drive of one or a series of laser pulses with arbitrary detuning and different pulse shapes. Because of the non-existence of system steady state under pulsed driving field, we adopt a different approach from the standard treatment to optomechanical entanglement. The situation of the entanglement evolution in high temperature is also discussed.
description: 11 pages, 4 figures. Accepted version of Optics Express, some errors are corrected
Analytic solutions of $q$-$P(A_1)$ near its critical points
Creators: name: Joshi, Nalini
name: Roffelsen, Pieter
Publisher: name: arXiv
Year: 2015
Subjects: subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences
subject: 39A13

description: For transcendental functions that solve non-linear $q$-difference equations, the best descriptions available are the ones obtained by expansion near critical points at the origin and infinity. We describe such solutions of a $q$-discrete Painlevé equation, with 7 parameters whose initial value space is a rational surface of type $A_1^{(1)}$. The resultant expansions are shown to approach series expansions of the classical sixth Painlevé equation in the continuum limit.
FAIR Data Spaces – a common Data Space for Industry, Science and Society
Creators: name: Boukhers, Zeyd
Publisher: name: Zenodo
Year: 2022
Subjects: FAIR Principales
Data Spaces
Gaia-X
NFDI

description: A presentation about the FAIR Data Spaces project at the EOSC symposium 2022 in Prague. The FAIR Data Spaces project is funded by the Federal Ministry of Education and Research (BMBF) from May 2021 to May 2024. In this project, the Gaia-X federated and secure data infrastructure and the National Research Data Infrastructure (NFDI) are connected to a common, cloud-based data space for industry and research in compliance with the FAIR Principles, i.e., to share data in a findable, accessible, interoperable, reusable way.
Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
Creators: name: Winston, Jenessa A.
name: Theriot, Casey M.
name: Thanissery, Rajani
name: Montgomery, Stephanie A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Clostridium difficile is an anaerobic, gram-positive, spore-forming enteric pathogen that is associated with increasing morbidity and mortality and consequently poses an urgent threat to public health. Recurrence of a C. difficile infection (CDI) after successful treatment with antibiotics is high, occurring in 20–30% of patients, thus necessitating the discovery of novel therapeutics against this pathogen. Current animal models of CDI result in high mortality rates and thus do not approximate the chronic, insidious disease manifestations seen in humans with CDI. To evaluate therapeutics against C. difficile, a mouse model approximating human disease utilizing a clinically-relevant strain is needed. This protocol outlines the cefoperazone mouse model of CDI using a clinically-relevant and genetically-tractable strain, {"type":"entrez-nucleotide","attrs":{"text":"R20291","term_id":"774925","term_text":"R20291"}}R20291. Techniques for clinical disease monitoring, C. difficile bacterial enumeration, toxin cytotoxicity, and histopathological changes throughout CDI in a mouse model are detailed in the protocol. Compared to other mouse models of CDI, this model is not uniformly lethal at the dose administered, allowing for the observation of a prolonged clinical course of infection concordant with the human disease. Therefore, this cefoperazone mouse model of CDI proves a valuable experimental platform to assess the effects of novel therapeutics on the amelioration of clinical disease and on the restoration of colonization resistance against C. difficile.
Monotonous (Semi-)Nonnegative Matrix Factorization
Creators: name: Bhatt, Nirav
name: Ayyar, Arun
Publisher: name: arXiv
Year: 2015
Subjects: subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences
subject: I.2

description: Nonnegative matrix factorization (NMF) factorizes a non-negative matrix into product of two non-negative matrices, namely a signal matrix and a mixing matrix. NMF suffers from the scale and ordering ambiguities. Often, the source signals can be monotonous in nature. For example, in source separation problem, the source signals can be monotonously increasing or decreasing while the mixing matrix can have nonnegative entries. NMF methods may not be effective for such cases as it suffers from the ordering ambiguity. This paper proposes an approach to incorporate notion of monotonicity in NMF, labeled as monotonous NMF. An algorithm based on alternating least-squares is proposed for recovering monotonous signals from a data matrix. Further, the assumption on mixing matrix is relaxed to extend monotonous NMF for data matrix with real numbers as entries. The approach is illustrated using synthetic noisy data. The results obtained by monotonous NMF are compared with standard NMF algorithms in the literature, and it is shown that monotonous NMF estimates source signals well in comparison to standard NMF algorithms when the underlying sources signals are monotonous.
Oedera corymbosa N. G. Bergh 2018, comb. nov.
Creators: name: Bergh, Nicola G.
name: Bentley, Joanne
name: Verboom, George Anthony
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Asterales
Asteraceae
Oedera
Oedera corymbosa

description: 20. Oedera corymbosa (Bolus) N.G.Bergh, comb. nov.
 Basionym: Nestlera corymbosa Bolus in Oliver (1895: Pl. 2324). Relhania corymbosa (Bolus) Bremer (1976a: 35).—Type: SOUTH AFRICA, hills near Touws River Railway Station, 2600 ft., 1885, Bolus 7355 (BOL, lectotype! [designated by Bremer 1976a]; K, isolectotype).
description: Published as part of Bergh, Nicola G., Bentley, Joanne & Verboom, George Anthony, 2018, Classification of the Relhania generic group (Asteraceae, Gnaphalieae) revisited using molecular phylogenetic analysis, pp. 101-132 in Phytotaxa 344 (2) on page 122, DOI: 10.11646/phytotaxa.344.2.1, http://zenodo.org/record/13719571
title: Vergleich der Baseline Charakteristika von PsA Patienten der nicht-interventionellen Studie SUSTAIN mit denen der randomisierten klinischen Studien PSUMMIT I und II zur Behandlung der Psoriasis Arthritis mit Ustekinumab
Creators: name: Wendler, Jörg
name: Schwarze, Ilka
name: Hamann, Frank
name: Behrens, Juliane
name: Movshovich, Evgenia
name: Gruppe, Traugott
name: Behrens, Frank
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: In der klinischen Routine kann sich das Patientenkollektiv bezüglich Krankheitsaktivität und Komorbiditäten von dem in randomisierten klinischen Studien (randomized clinical trial - RCT) unterscheiden. Methoden: SUSTAIN ist eine prospektive, multizentrische, nicht-interventionelle[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
RIGHT TO PRIVACY - THE FUNDAMENTAL RIGHT
Creators: name: Tarannum Jahan
Publisher: name: Zenodo
Year: 2022

description: Abstract: The right to privacy in India has been contested in court, but it was finally codified into their constitution in 2017. However, it failed as many thought it would pose a problem for the investigations and powers of the states if the right to privacy meant “it would elevate every private/ civil communication to that of State papers.” In the two mentioned cases, the right to privacy was brought up by the defendants but was struck down by the Supreme Court, which denied that the right to privacy itself existed in the constitution, so it was not applicable for the defendants to use in Court. It was not until the case involving Justice K.S. Puttuswamy which brought about a change and a decision by the 9 Supreme Court justices to add the right to privacy in Part III of the Indian Constitution. In the year 2000, an effort has been made by our legislature to embrace privacy issues relating to a computer system under the purview of the IT Act, 2000. After the Supreme Court’s landmark judgment on the right to privacy in the Justice KS Puttaswamy case which suggested that the government should legislate a data privacy law to ensure that the fundamental right to privacy is adequately protected to protect interrelationships. A noteworthy change is in the form of exemptions extended to government agencies concerning data processing. This exemption may be examined in light of the recent Supreme Court judgment in the Pegasus spyware case.
Isolation and Characterization of Single Cells from Zebrafish Embryos
Creators: name: Samsa, Leigh Ann
name: Qian, Li
name: Fleming, Nicole
name: Magness, Scott
name: Liu, Jiandong
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The zebrafish (Danio rerio) is a powerful model organism to study vertebrate development. Though many aspects of zebrafish embryonic development have been described at the morphological level, little is known about the molecular basis of cellular changes that occur as the organism develops. With recent advancements in microfluidics and multiplexing technologies, it is now possible to characterize gene expression in single cells. This allows for investigation of heterogeneity between individual cells of specific cell populations to identify and classify cell subtypes, characterize intermediate states that occur during cell differentiation, and explore differential cellular responses to stimuli. This study describes a protocol to isolate viable, single cells from zebrafish embryos for high throughput multiplexing assays. This method may be rapidly applied to any zebrafish embryonic cell type with fluorescent markers. An extension of this method may also be used in combination with high throughput sequencing technologies to fully characterize the transcriptome of single cells. As proof of principle, the relative abundance of cardiac differentiation markers was assessed in isolated, single cells derived from nkx2.5 positive cardiac progenitors. By evaluation of gene expression at the single cell level and at a single time point, the data support a model in which cardiac progenitors coexist with differentiating progeny. The method and work flow described here is broadly applicable to the zebrafish research community, requiring only a labeled transgenic fish line and access to microfluidics technologies.
title: Frühzeitige und langanhaltende Wirksamkeit von Ustekinumab führt zu hoher Therapie-Zufriedenheit bei Patienten mit aktiver Psoriasis Arthritis und deren behandelnden Ärzten – Ergebnisse der nicht-interventionellen Studie SUSTAIN
Creators: name: Wendler, Jörg
name: Schwenke, Holger
name: Wagener, Peter
name: Behrens, Juliane
name: Movshovich, Evgenia
name: Behrens, Frank
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: SUSTAIN ist eine prospektive, multizentrische, nicht-interventionelle Studie in Deutschland zur Untersuchung der Langzeitwirksamkeit und –sicherheit, Lebensqualität und weiterer patientenrelevanter Behandlungsergebnisse im klinischen Alltag bei Patienten mit aktiver Psoriasis-Arthritis[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Holographic correspondence in topological superconductors
Creators: name: Palumbo, Giandomenico
name: Pachos, Jiannis K.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We analytically derive a compatible family of effective field theories that uniquely describe topological superconductors in 3D, their 2D boundary and their 1D defect lines. We start by deriving the topological field theory of a 3D topological superconductor in class DIII, which is consistent with its symmetries. Then we identify the effective theory of a 2D topological superconductor in class D living on the gapped boundary of the 3D system. By employing the holographic correspondence we derive the effective chiral conformal field theory that describes the gapless modes living on the defect lines or effective boundary of the class D topological superconductor. We demonstrate that the chiral central charge is given in terms of the 3D winding number of the bulk which by its turn is equal to the Chern number of its gapped boundary.
description: 4 pages
title: Ustekinumab ist gut verträglich bei der Behandlung der aktiven Psoriasis Arthritis – Ergebnisse der nicht-interventionellen Studie SUSTAIN
Creators: name: Wendler, Jörg
name: Schwarze, Ilka
name: Sieburg, Maren
name: Movshovich, Evgenia
name: Behrens, Juliane
name: Gruppe, Traugott
name: Behrens, Frank
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Für die Behandlung der Psoriasis Arthritis sind verschiedene Biologika mit vergleichbarer Wirksamkeit auf dem Markt. Die Sicherheit des Präparates spielt eine sehr große Rolle bei der Wahl einer geeigneten Therapie für den Patienten. SUSTAIN ist eine prospektive, multizentrische,[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Mucin Agarose Gel Electrophoresis: Western Blotting for High-molecular-weight Glycoproteins
Creators: name: Ramsey, Kathryn A.
name: Rushton, Zachary L.
name: Ehre, Camille
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Mucins, the heavily-glycosylated proteins lining mucosal surfaces, have evolved as a key component of innate defense by protecting the epithelium against invading pathogens. The main role of these macromolecules is to facilitate particle trapping and clearance while promoting lubrication of the mucosa. During protein synthesis, mucins undergo intense O-glycosylation and multimerization, which dramatically increase the mass and size of these molecules. These post-translational modifications are critical for the viscoelastic properties of mucus. As a result of the complex biochemical and biophysical nature of these molecules, working with mucins provides many challenges that cannot be overcome by conventional protein analysis methods. For instance, their high-molecular-weight prevents electrophoretic migration via regular polyacrylamide gels and their sticky nature causes adhesion to experimental tubing. However, investigating the role of mucins in health (e.g., maintaining mucosal integrity) and disease (e.g., hyperconcentration, mucostasis, cancer) has recently gained interest and mucins are being investigated as a therapeutic target. A better understanding of the production and function of mucin macromolecules may lead to novel pharmaceutical approaches, e.g., inhibitors of mucin granule exocytosis and/or mucolytic agents. Therefore, consistent and reliable protocols to investigate mucin biology are critical for scientific advancement. Here, we describe conventional methods to separate mucin macromolecules by electrophoresis using an agarose gel, transfer protein into nitrocellulose membrane, and detect signal with mucin-specific antibodies as well as infrared fluorescent gel reader. These techniques are widely applicable to determine mucin quantitation, multimerization and to test the effects of pharmacological compounds on mucins.
Quick Guides for Gaining Fellowship(s)
Creators: name: Pielichaty, Hanya
Publisher: name: National Teaching Repository
Year: 2022
Subjects: Other education not elsewhere classified

description: These resources come from a community network at my own university. They aim of the guides is to provide helpful and accessible support to assist colleagues in applying for Associate Fellow (D1), Fellow (D2) or Senior Fellow (D3) accreditation with Advance HE. Please note these documents are to be used as a support tool and not as a replacement for information from Advance HE and/or your own institution.
title: Ustekinumab zeigt gute und langanhaltende Wirksamkeit als first-, second- und third-line Biologikum bei Patienten mit aktiver Psoriasis Arthritis – Ergebnisse der nicht-interventionellen Studie SUSTAIN
Creators: name: Wendler, Jörg
name: Wagener, Peter
name: Wroblewska, Katharina
name: Behrens, Juliane
name: Movshovich, Evgenia
name: Behrens, Frank
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Psoriasis Arthritis ist eine chronische Erkrankung, die meist lebenslange Behandlung benötigt. Verschiedene Studien zeigen verringerte Wirksamkeit und geringere Therapieverweildauer in Abhängigkeit von der Anzahl der Therapien. Daher ist schon zu Beginn die Wahl der für den[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Additional file 1 of Communication skills training in advance care planning: a survey among medical students at the University of Antwerp
Creators: name: van de Wiel, Mick
name: Bombeke, Katrien
name: Janssens, Annelies
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 1: Appendix 1. Part 1: Demographics. Part 2: Knowledge questions. Part 3: PEAT 7 – Communication. Part 4: COVID-19 pandemic influences ACP.
title: Selbstberichteter Krankheitsschaden bei SLE – 5-Jahres-Verlaufsdaten der LuLa-Studie
Creators: name: Chehab, Gamal
name: Richter, Jutta
name: Fischer-Betz, Rebecca
name: Winkler-Rohlfing, Borgi
name: Schneider, Matthias
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Krankheitsschaden stellt einen wichtigen klinischen Endpunkt in der Betreuung von Patienten mit systemischen Lupus erythematodes (SLE) dar und ist mit Morbidität und Mortalität assoziiert. Eine regelmäßige Dokumentation wird in den aktuellen Empfehlungen zum Management[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Humoral and cytotoxic effector mechanisms of eliciting protection against Plasmodium sporozoite and liver stage infection
Creators: name: O'Connor, James
Publisher: name: The Australian National University
Year: 2021

description: The parasites of the Plasmodium genus have arguably caused more deaths than any other pathogen in human history and their ability to evade human immunity has compounded its virulence. The multi-stage life cycle in both vertebrates and mammals, as well as the several forms it takes during its lifecycle, only make investigation of this parasite, and more importantly, how to combat it, extremely difficult. Recent developments in imaging techniques such as intravital imaging, and the ability to observe the parasite transition through these unique morphologies in real time, has enabled researchers to gain a more sound understanding of how the parasite responds to drug designs, immune components and interacts with the vast amount of cell types in the body. In this thesis, these techniques are utilised to investigate how the human immune repertoire interacts with the Plasmodium parasite in live animal models and how the immune system locates, identifies and destroys the parasite. CD8 T lymphocytes are undoubtedly one of the key cell types in locating and destroying Plasmodium at the liver stage. The ability for these cells to establish and maintain resident populations in the liver, as well as their ability to induce sterilising immunity through clustering and effector responses has been well documented. In addition, their ability to undergo morphological changes and differentiate into effector cells after immunisation is a rather exciting discovery and may play a role in finally developing a long lasting immune response to a vaccine. Recent vaccine strategies utilising entire parasite structures has identified several target sequences on the plasmodium surface which are selectively targeted by Pf(CSP) antibodies and have demonstrated substantial protection in the skin. In addition, these proteins also have the ability to generate effector CD8 T lymphocyte populations in the liver and may explain why protection fails to last in current vaccine designs which only use NANP repeat sequences. The interplay between the activation, migration and residence of CD8 T-lymphocytes, as well as the ability for these cells to execute their effector function at the site of liver infection, and the ability for high affinity antibodies to induce cytotoxicity in the Plasmodium parasites may reveal ideal 'triple whammy' strategies for vaccine design. This thesis investigates these components, and ultimately may help drive the design and generation of a vaccine which incorporates all 3 key immunological phenomena to generate a robust and long lasting vaccine against Plasmodium and reduce the catastrophic disease burden of malaria both in endemic regions and across the globe.
Reliable Prediction of Channel Assignment Performance in Wireless Mesh Networks
Creators: name: Kala, Srikant Manas
name: Musham, Ranadheer
name: Reddy, M Pavan Kumar
name: Tamma, Bheemarjuna Reddy
Publisher: name: arXiv
Year: 2015
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: The advancements in wireless mesh networks (WMN), and the surge in multi-radio multi-channel (MRMC) WMN deployments have spawned a multitude of network performance issues. These issues are intricately linked to the adverse impact of endemic interference. Thus, interference mitigation is a primary design objective in WMNs. Interference alleviation is often effected through efficient channel allocation (CA) schemes which fully utilize the potential of MRMC environment and also restrain the detrimental impact of interference. However, numerous CA schemes have been proposed in research literature and there is a lack of CA performance prediction techniques which could assist in choosing a suitable CA for a given WMN. In this work, we propose a reliable interference estimation and CA performance prediction approach. We demonstrate its efficacy by substantiating the CA performance predictions for a given WMN with experimental data obtained through rigorous simulations on an ns-3 802.11g environment.
description: Accepted in ICACCI-2015
Additional file 1 of Continuous diagnostic models for volume deficit in patients with acute diarrhea
Creators: name: Lee, J. Austin
name: Qu, Kexin
name: Gainey, Monique
name: Kanekar, Samika S.
name: Barry, Meagan A.
name: Nasrin, Sabiha
name: Alam, Nur H.
name: Schmid, Christopher H.
name: Levine, Adam C.
Publisher: name: figshare
Year: 2022
Subjects: subject: Biotechnology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy
subject: Computational Biology

description: Additional file 1. S1 Appendix. Pre-defined protocols for measurement of all clinical variables in the DHAKA Model. S2 Appendix. DHAKA Formula. S3 Appendix. Pre-defined protocols for measurement of all clinical variables in the NIRUDAK Model. S4 Appendix. NIRUDAK Formula.
Oedera tricephala N. G. Bergh 2018, comb. nov.
Creators: name: Bergh, Nicola G.
name: Bentley, Joanne
name: Verboom, George Anthony
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Asterales
Asteraceae
Oedera
Oedera tricephala

description: 21. Oedera tricephala (Candolle) N.G.Bergh, comb. nov.
 Basionym: Polychaetia tricephala Candolle (1838a: 285). Relhania tricephala (DC.) Bremer (1976a: 36).—Type: SOUTH AFRICA, Roodezand between Nuwekloof and Slangenheuvel, below 1000 ft., Drège 572 (G–DC, holotype!; G, P, S, W, isotypes).
description: Published as part of Bergh, Nicola G., Bentley, Joanne & Verboom, George Anthony, 2018, Classification of the Relhania generic group (Asteraceae, Gnaphalieae) revisited using molecular phylogenetic analysis, pp. 101-132 in Phytotaxa 344 (2) on page 123, DOI: 10.11646/phytotaxa.344.2.1, http://zenodo.org/record/13719571
Utilizing Combined Methodologies to Define the Role of Plasma Membrane Delivery During Axon Branching and Neuronal Morphogenesis
Creators: name: Gupton, Stephanie L.
name: Winkle, Cortney C.
name: Hanlin, Christopher C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: During neural development, growing axons extend to multiple synaptic partners by elaborating axonal branches. Axon branching is promoted by extracellular guidance cues like netrin-1 and results in dramatic increases to the surface area of the axonal plasma membrane. Netrin-1-dependent axon branching likely involves temporal and spatial control of plasma membrane expansion, the components of which are supplied through exocytic vesicle fusion. These fusion events are preceded by formation of SNARE complexes, comprising a v-SNARE, such as VAMP2 (vesicle-associated membrane protein 2), and plasma membrane t-SNAREs, syntaxin-1 and SNAP25 (synaptosomal-associated protein 25). Detailed herein is a multi-pronged approach used to examine the role of SNARE mediated exocytosis in axon branching. The strength of the combined approach is data acquisition at a range of spatial and temporal resolutions, spanning from the dynamics of single vesicle fusion events in individual neurons to SNARE complex formation and axon branching in populations of cultured neurons. This protocol takes advantage of established biochemical approaches to assay levels of endogenous SNARE complexes and Total Internal Reflection Fluorescence (TIRF) microscopy of cortical neurons expressing VAMP2 tagged with a pH-sensitive GFP (VAMP2-pHlourin) to identify netrin-1 dependent changes in exocytic activity in individual neurons. To elucidate the timing of netrin-1-dependent branching, time-lapse differential interference contrast (DIC) microscopy of single neurons over the order of hours is utilized. Fixed cell immunofluorescence paired with botulinum neurotoxins that cleave SNARE machinery and block exocytosis demonstrates that netrin-1 dependent axon branching requires SNARE-mediated exocytic activity.
"GLOBAL WARMING: EFFECTS AND CAUSES"
Creators: name: Mr. Kailas Satyawan Shelar
Publisher: name: Zenodo
Year: 2022

description: Abstract Global warming is the unusually rapid increase in Earth's average surface temperature over the past century primarily due to the greenhouse gases released by people burning fossil fuels. The scientific and environmental community is on the same page regarding the bitter reality of global warming and the involvement of human factor in it. Global warming is a big hazard and appropriate measures must be taken to tackle this serious problem. This problem is not only causing trouble to the human beings but also to animals and plants. Melting of polar ice caps will lead to floods which can cause mayhem everywhere. Rise of sea levels will devastate agricultural and fishing activities. To embark upon these problems, some remedial steps must be timely taken which include but are not limited to the use of renewable sources of energy and stopping deforestation. Innovative solutions must be brought forward to end this hazard once and forever.
title: SSC in older age: Frequent and with a different phenotype. Data of the German Network for Systemic Sclerosis
Creators: name: Moinzadeh, Pia
name: Riemekasten, Gabriela
name: Blank, Horst
name: Henes, Jörg
name: Kötter, Ina
name: Siegert, Elise
name: Pfeiffer, Christiane
name: Zeidler, Gabriele
name: Schmalzing, Marc
name: Günther, Claudia
name: Susok, Laura
name: Worm, Margitta
name: Kreuter, Alexander
name: Sunderkötter, Cord
name: Müller-Ladner, Ulf
name: Juche, Aaron
name: Aberer, Elisabeth
name: Schmeiser, Tim
name: Krieg, Thomas
name: Kuhr, Kathrin
name: Hunzelmann, Nico
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Background: Systemic sclerosis (SSc) is a very heterogeneous multisystem connective tissue disease. The majority of affected patients developinitial clinical symptoms between the age of 30 to 50 years. It is not known whether an aging population affects the clinical phenotype of SSc. Objectives: [for full text, please go to the a.m. URL]
description: 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Oedera spathulifolia N. G. Bergh 2018, comb. nov.
Creators: name: Bergh, Nicola G.
name: Bentley, Joanne
name: Verboom, George Anthony
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Asterales
Asteraceae
Oedera
Oedera spathulifolia

description: 22. Oedera spathulifolia (K.Bremer) N.G.Bergh, comb. nov.
 Basionym: Relhania spathulifolia Bremer (1976a: 33).— Type: SOUTH AFRICA, between Bosheuwel and Soutbos, shore of vlei, 1972, Bremer 517 (S, holotype!; NBG, isotype!).
description: Published as part of Bergh, Nicola G., Bentley, Joanne & Verboom, George Anthony, 2018, Classification of the Relhania generic group (Asteraceae, Gnaphalieae) revisited using molecular phylogenetic analysis, pp. 101-132 in Phytotaxa 344 (2) on page 123, DOI: 10.11646/phytotaxa.344.2.1, http://zenodo.org/record/13719571
Artificial water bodies as amphibian breeding sites: the case of the common midwife toad (Alytes obstetricans) in central Spain
Creators: name: Caballero-Díaz, Carlos
name: Sánchez-Montes, Gregorio
name: Gómez, Iván
name: Díaz-Zúñiga, Ana
name: Martínez-Solano, Íñigo
Publisher: name: Brill Online
Year: 2022
Subjects: Ecology not elsewhere classified

description: Natural breeding sites for amphibians are decreasing in quantity and quality in temperate regions, resulting in local extinctions and increasing population fragmentation. Artificial water bodies (e.g., water tanks or cattle troughs) can represent suitable reproductive habitats for some amphibians, but demographic data are required to assess this assumption. We evaluated the role of artificial water bodies in the persistence of a species of population concern, the common midwife toad, Alytes obstetricans (Laurenti 1768), at local and regional scales. We surveyed 275 water bodies to characterize the distribution of the species and detected 63 breeding populations of A. obstetricans where we estimated larval abundance. In addition, we monitored two populations for three consecutive breeding seasons using capture-mark-recapture methods based on photo-identification, assessing abundance, breeding success and the use of space of adult individuals captured on multiple occasions. Our results show that artificial sites are preferentially used as breeding sites in the region compared to natural aquatic habitats, providing key habitat for the species and hosting much larger numbers and densities of larvae than natural sites. At local scale, populations of A. obstetricans in artificial sites were abundant and characterized by high male breeding success. However, adults are spatially aggregated around breeding sites, with small home ranges, implying high vulnerability to population fragmentation. Our results suggest artificial breeding sites can sustain viable populations of A. obstetricans, provided measures promoting connectivity among breeding nuclei are considered.
Hierarchical networks of scientific journals
Creators: name: Palla, Gergely
name: Tibély, Gergely
name: Mones, Enys
name: Pollner, Péter
name: Vicsek, Tamás
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Digital Libraries (cs.DL)
subject: Applications (stat.AP)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Scientific journals are the repositories of the gradually accumulating knowledge of mankind about the world surrounding us. Just as our knowledge is organised into classes ranging from major disciplines, subjects and fields to increasingly specific topics, journals can also be categorised into groups using various metrics. In addition to the set of topics characteristic for a journal, they can also be ranked regarding their relevance from the point of overall influence. One widespread measure is impact factor, but in the present paper we intend to reconstruct a much more detailed description by studying the hierarchical relations between the journals based on citation data. We use a measure related to the notion of m-reaching centrality and find a network which shows the level of influence of a journal from the point of the direction and efficiency with which information spreads through the network. We can also obtain an alternative network using a suitably modified nested hierarchy extraction method applied to the same data. The results are weakly methodology-dependent and reveal non-trivial relations among journals. The two alternative hierarchies show large similarity with some striking differences, providing together a complex picture of the intricate relations between scientific journals.