cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Heart transplantation program in the era of mechanical circulatory support: Republic of Kazakhstan experience
Creators: name: Pya Yu.V.
name: Bekbossynov, S.T.
name: Bekbossynova, M.S.
name: Kuatbayev Ye.M.
name: Lesbekov, T.D.
name: Kaliyev, R.B.
name: Dzhetybayeva, S.K.
name: Medressova Assel Turarovna
name: Nurmykhametova Zh.A.
name: Murzagaliyev, M.U.
name: Novikova, S.P.
name: Kapyshev, T.S.
name: Smagulov, N.K.
name: Faizov, L.R.
name: Vakhrushev, I.A.
name: Andossova, S.A.
name: Myrzakhmetova G.Sh.
name: Nadirbekova G.Ye.
name: Shayssultanova, S.T.
name: Duyssenbina Zh.S.
Publisher: name: Клиническая и экспериментальная хирургия
Year: 2017
Subjects: ДИСТАНЦИОННАЯ ПЕРЕСАДКА
МЕХАНИЧЕСКАЯ ПОДДЕРЖКА КРОВООБРАЩЕНИЯ СЕРДЦА
КОНСЕРВАЦИЯ СЕРДЦА
ORGAN CARE SYSTEM
TRANSMEDICS
EX-VIVO PRESERVATION OF HEART
LEFT VENTRICULAR ASSIST DEVICE
MECHANICAL CIRCULATORY SUPPORT
HEART FAILURE
KAZAKHSTAN
HEART TRANSPLANTATION

description: Aim. Kazakhstan is a country where mechanical circulatory support program was established prior to heart transplantation (HT). Given the countries large land area and small population density transportation of scarce amount of donor hearts was the primary challenge for healthcare providers. Advances in the area of cardiac surgery, such as development of left ventricular assist device (VAD) and organ care system (OCS) Transmedics, allowed us to overcome the obstacles. In this study we aim to analyze and describe the results of the first 5 years of heart transplantation program in Kazakhstan. Methods. A prospective descriptive study analyzing the data of 42 patients was conducted. All the enrolled study subjects have undergone heart transplantation within a period between 2012 and 2016 in the National Research Cardiac Surgery Center, Astana, Kazakhstan. Primary and secondary outcomes of interest were cumulative survival, graft failure free period and incidence of adverse events. Results. Kaplan-Meier survival estimates for all patients after HT were 90% after 3 months, 82% after six months and 80% after twelve months. In the early postoperative period after HT 11 (26.1%) patients have experienced the following adverse events: 13 (30%) resternotomy due to bleeding, 3 (7%) sepsis, 1 (2.3%) stroke, 2 (4.7%) lymphorrhea from groin area, 2 (4.7%) -heart rhythm disturbances, and 6 patients (14.3%) had pneumonia. No cases of graft rejection were recorded. Conclusion. With all the confidence we can state that Kazakhstan has fully benefited from new advances. OCS Transmedics allowed preserving the heart for much longer period of time and making long distance transportation of donor heart possible. This study can further be followed up by studying the HT outcomes after OSC compared to standard cold storage. Moreover, another research studying the impact of heart preservation time in the OCS on the outcome of patient survival after HT can also be conducted.
Bourdieu e l’Europa: un rapporto a due dimensioni
Creators: name: Girometti, Andrea
Publisher: name: Universita' degli Studi di Salerno
Year: 2021
Subjects: European sociology
Intellectual critical
European utopia

description: The essay focuses on the multidimensional relationship between Pierre Bourdieu’s sociology and Europe. Firstly, it is emphasized that the Bourdieusian approach is from its very first steps an integral part of the reconstruction of a European sociology and therefore of the conditions that make it thinkable and possible. Secondly, the European dimension assumes an increasingly explicit sociological-political character, particularly visible in the years of maturity of the French intellectual. In this case Bourdieu is directly engaged in the political field at a juncture in which the conservative neoliberal revolution is affirming, even in the European space. In this double movement, there is a common thread that distinguishes Bourdieusian sociology: the definition of a rigorous and innovative theoretical approach (never separated from empirical analysis) combined with a particular commitment with repercussions also in the political field. A commitment that has assumed the construction of a European utopia as a strategic objective.
Corrections to Eikonal Approximation for Nuclear Scattering at Medium Energies
Creators: name: Buuck, Micah
name: Miller, Gerald A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The upcoming Facility for Rare Isotope Beams (FRIB) at the National Superconducting Cyclotron Laboratory (NSCL) at Michigan State University has reemphasized the importance of accurate modeling of low energy nucleus-nucleus scattering. Such calculations have been simplified by using the eikonal approximation. As a high energy approximation, however, its accuracy suffers for the medium energy beams that are of current experimental interest. A prescription developed by Wallace \cite{Wallace:1971zz,Wallace:1973iu} that obtains the scattering propagator as an expansion around the eikonal propagator (Glauber approach) has the potential to extend the range of validity of the approximation to lower energies. Here we examine the properties of this expansion, and calculate the first-, second-, and third-order corrections for the scattering of a spinless particle off of a ${}^{40}$Ca nucleus, and for nuclear breakup reactions involving ${}^{11}$Be. We find that, including these corrections extends the lower bound of the range of validity of the down to energies of 40 MeV. At that energy the corrections provide as much as a 15\% correction to certain processes.
description: 17 pages 11 figure. arXiv admin note: text overlap with arXiv:nucl-th/9607049 by other authors. This reference is credited and cited. Figure replacement and reference added
Novel method for ex vivo preservation of donor heart using blood cardioplegia and conditioning
Creators: name: Pya Yu.V.
name: Kaliyev, R.B.
name: Bekbossynov, S.T.
name: Lesbekov, T.D.
name: Nurmykhametova Zhuldyz А.
name: Smagulov, N.K.
name: Novikova, S.P.
name: Ashyrov Zh.Z.
name: Faizov, L.R.
name: Medressova, A.T.
name: Murzagaliyev, M.O.
Publisher: name: Клиническая и экспериментальная хирургия
Year: 2017
Subjects: КОНДИЦИОНИРОВАНИЕ ДОНОРСКОГО СЕРДЦА
КРОВЯНАЯ КАРДИОПЛЕГИЯ
ORGAN CARE SYSTEM
ТРАНСПЛАНТАЦИЯ СЕРДЦА

description: Background. In 2012, we initiated the first heart transplant programme in Kazakhstan. Donor hearts are transported from distant regions (>1000 km) to be transplanted at our Center. The ob jective of this study was to assess the feasibility of blood cardioplegia as an alternative method to Custodiol for heart preservation. Methods. We performed a retrospective analysis of prospectively collected data. Between May 2014 and February 2016, 20 patients with heart failure underwent heart transplantation using the Organ Care System. Of these, we arrested the donor hearts before explant and before implant using blood cardioplegia and conditioning (ultrafiltration, levosimendan) in ten patients and with standard Custodiol in ten other patients. Results. Preoperative risk factors were comparable in both groups. All patients were alive on the 30th day post implant in both groups. Results were similar for the blood cardioplegia compared to the Custodiol groups for: mean total warm ischemic time was 84.2±28 vs 86.9±8.4 min (p=0.001). Mean ex vivo perfusion time was 266.5±86.7 vs 260.4±88.4 min (p=0.87). Mean venous lactate at the start of perfusion 2.2±0.7 vs 3.4±0.8 mmol/l and at the end of perfusion 5.0±1.9 vs 9.2± 2.1 mmol/l (p=0.001). Seven-day tissue myocardial Doppler results were normal in both groups, except for one patient in the Custodiol group who had right ventricular dysfunction. There were no statistically significant differences in ICU stay between the two groups. Mean ECMO duration was 29.5±28.4 vs 78.4±89 hours (p=0.002). Conclusion. Our observations show that blood cardioplegia and conditioning could be an alternative method for myocardial protection in distant procurement and preservation of donor hearts in the Organ Care System.
The effect of Waste Glass as Partial Replacement of cement on Properties of Concrete
Creators: name: Khoso, Salim
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 400504
subject: Construction engineering
classificationCode: 400505
subject: Construction materials
classificationCode: 400513
subject: Water resources engineering
classificationCode: 400509
subject: Structural dynamics
classificationCode: 400510
subject: Structural engineering

description: The utilization of solid waste materials or industrial waste as partial substitution of cement is growing in construction industry all around world to reduce the consumption of cement consequently reduction in CO2 emission into the atmosphere and reduction in energy consumption. The aim of this study is to improve the strength of concrete made by replacing the cement with waste glass. In this study the cement was replaced with waste glass as 5, 10, 15, 20 and 25% by weight of cement with constant water to binder ratio of 0.5. One mixture of control concrete and five modified concrete mixtures prepared with replacement of cement with waste glass were prepared. Workability, density of hardened concrete, Compressive and tensile strength of control and modified concrete were tested. The experimental test results revealed that, significant improvement was observed at 10% replacement of cement with waste glass on the investigated properties of concrete.
Peierls brackets in non-Lagrangian field theory
Creators: name: Sharapov, Alexey
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: The concept of Lagrange structure allows one to systematically quantize the Lagrangian and non-Lagrangian dynamics within the path-integral approach. In this paper, I show that any Lagrange structure gives rise to a covariant Poisson brackets on the space of solutions to the classical equations of motion, be they Lagrangian or not. The brackets generalize the well-known Peierls' bracket construction and make a bridge between the path-integral and the deformation quantization of non-Lagrangian dynamics.
description: 31 pages, v2 a reference added
Comprehensive gene expression profiling and immunohistochemical studies support application of immunophenotypic algorithm for molecular subtype classification in diffuse large B-cell lymphoma: a report from the International DLBCL Rituximab-CHOP Consortium Program Study
Creators: name: Xu-Monette, Z Y
name: Dybkær, K
name: Dunphy, C H
name: Tzankov, A
name: Wang, H-Y
name: Hsi, E D
name: Zhou, F
name: Miranda, R N
name: Green, T M
name: d'Amore, E S G
name: Bhagat, G
name: van Krieken, J H
name: Montes-Moreno, S
name: Wen, W
name: Kahl, B S
name: Zu, Y
name: O'Neill, S
name: Go, R S
name: Czader, M
name: Chiu, A
name: Choi, W W L
name: Zhao, X F
name: Orazi, A
name: Visco, C
name: Zhao, X
name: Huang, Q
name: Li, Y
name: Liu, W-m
name: Tam, W
name: Tong, J
name: Winter, J N
name: Li, Y
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Gene expression profiling (GEP) has stratified diffuse large B-cell lymphoma (DLBCL) into molecular subgroups that correspond to different stages of lymphocyte development - namely germinal center B-cell-like and activated B-cell-like. This classification has prognostic significance, but GEP is expensive and not readily applicable into daily practice, which has lead to immunohistochemical algorithms proposed as a surrogate for GEP analysis. We assembled tissue microarrays from 475 de novo DLBCL patients who were treated with rituximab-CHOP chemotherapy. All cases were successfully profiled by GEP on formalin-fixed, paraffin-embedded tissue samples. Sections were stained with antibodies reactive with CD10, GCET1, FOXP1, MUM1, and BCL6 and cases were classified following a rationale of sequential steps of differentiation of B-cells. Cutoffs for each marker were obtained using receiver operating characteristic curves, obviating the need for any arbitrary method. An algorithm based on the expression of CD10, FOXP1, and BCL6 was developed that had a simpler structure than other recently proposed algorithms and 92.6% concordance with GEP. In multivariate analysis, both the International Prognostic Index and our proposed algorithm were significant independent predictors of progression-free and overall survival. In conclusion, this algorithm effectively predicts prognosis of DLBCL patients matching GEP subgroups in the era of rituximab therapy.
Heart transplantation in pediatric patient with Noonan syndrome
Creators: name: Kotlukova, N.P.
name: Zaklyazminskaya, E.V.
name: Wilmot, I.
Publisher: name: Клиническая и экспериментальная хирургия
Year: 2017
Subjects: HYPERTROPHIC CARDIOMYOPATHY
NOONAN SYNDROME
RAS-CASCADE
HEART TRANSPLANTATION
PTPN11
DNA DIAGNOSTICS

description: Introduction. Syndromes caused by mutations in the genes encoding components of the RAS/ MAPK signaling pathway (RASopathies) are clinically and genetically heterogeneous. The most frequent manifestations of these syndromes are congenital heart and vascular defects, cardiomyopathies, skeletal abnormalities, multiple lentigines and other variable delay in physical and cognitive development, predisposition to neoplasia. More than 10 genes are known to be causative for the RASopathies, and this list continues to expand. The unfolded clinical phenotype of RASopathies is quite obvious, however, at the early stages of the disease its diagnosis might be challenging. Aim. The present case reports present case reports of a successful heart transplantation in a 3-year and 8-month-old child with Noonan syndrome. Materials and methods. Clinical biochemistry and instrumental examinations included electrocardiography, doppler echocardiography, 24-h Holter recording, and enzyme analysis. Genetic testing involved routine chromosome analysis (karyotyping), Sanger sequencing of the codingand adjacent intronic regions of the LMNA, PTPN11, and RAF1 genes. Clinical case. The girl first entered the pediatric cardiology department at 4.5 months of age with symptoms of heart failure. Symmetric obstructive hypertrophic cardiomyopathy was diagnosed. Given the multiple phenotypic features, the syndromic nature of the disease was suspected. Noonan syndrome caused by the p. Gln510Glu mutation in the PTPN11 gene was diagnosed. As the disease progressed rapidly, the infant underwent heart transplantation. In 1 year follow-up the girl is in stable condition with no physical complaints. Conclusion. It suggests that mutation-specific RAS/MAPK pathway inhibition might be considered for patients with RASopathies. But for now the heart transplantation is the only proven option for pediatric patients with rapidly progressing cardiac hypertrophy.
Replica Fourier Transform: Properties and Applications
Creators: name: Crisanti, A.
name: De Dominicis, C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: The Replica Fourier Transform is the generalization of the discrete Fourier Transform to quantities defined on an ultrametric tree. It finds use in con- junction of the replica method used to study thermodynamics properties of disordered systems such as spin glasses. Its definition is presented in a system- atic and simple form and its use illustrated with some representative examples. In particular we give a detailed discussion of the diagonalization in the Replica Fourier Space of the Hessian matrix of the Gaussian fluctuations about the mean field saddle point of spin glass theory. The general results are finally discussed for a generic spherical spin glass model, where the Hessian can be computed analytically.
Paesaggio sacro, pittura di paesaggio, paesaggio costruito. Ricerche in corso sul paesaggio nemorense e il Museo delle Navi romane
Creators: name: Incutti, Agostina;Pallottino, Elisabetta;Porretta, Paola
Publisher: name: La Rivista di Engramma
Year: 2023
Subjects: Museo delle Navi Romane di Nemi
Vittorio Morpurgo
James Frazer
landscape of Nemi

description: The interpretation of the mythological scenarios of Frazer together with the paintings of the landscape of Nemi, rouged between the 19th and the 20th century, have created an imagination that has transfigured real landscapes into sacred places. The iconographic and mythological repertory reveals the intangible power of the place and, over time, has overlapped with the parallel destiny of the Roman ships and the physical ancient traces —as the Diana’s Sanctuary and the Roman road called via Virbia or clivus aricinus— which are now barely visible, fragmented and awaiting further studies. This paper aims both to explore the landscape on Nemi’s lakeshore intangible aspects and built features, and to examine physical and visual relationships which the Museo delle Navi Romane intentionally establishes with the context. The museum was designed by Vittorio Morpurgo in the late 1930s to house the remains of ancient Roman ships recovered from the Lake of Nemi. The building was severely damaged in the 1944 fire, which completely destroyed the rest of the hulls. Since then, the museum has carried out several reorganizations and restorations, some of which have gravely compromised the original design, and even today the museum is still waiting for a renewed exhibition vocation and a direct link with the landscape and the ancient context.
Skeletal muscle drculatory support
Creators: name: Stephenson Larry
Publisher: name: Клиническая и экспериментальная хирургия
Year: 2017
Subjects: КАРДИОМИОПАТИИ
СЕРДЕЧНАЯ НЕДОСТАТОЧНОСТЬ
ДИНАМИЧЕСКАЯ КАРДИОМИОПЛАСТИКА
СКЕЛЕТНО-МЫШЕЧНЫЙ ЖЕЛУДОЧЕК
CARDIOMYOPATHIES
HEART FAILURE
DYNAMIC CARDIOMYOPLASTY
SKELETAL MUSCLE VENTRICLE

description: The author is one of the most famous cardiovascular surgeons in the world, actively develops theoretical and experimental basis of circulatory support assisted by biological skeletal muscle ventricle. In this article the results of study of dynamic cardiomyoplasty, aortomyoplasty (counterpulsation) and skeletal muscle ventricle for the purpose of organ-preserving surgical cardiomyopathy treatment in long-term experiment in animals are represented. A review of current clinical experience and long-term results of cardiomyoplasty usage is also given.
Disruption of the 5S RNP–Mdm2 interaction significantly improves the erythroid defect in a mouse model for Diamond-Blackfan anemia
Creators: name: Jaako, P
name: Zhang, Y
name: Olsson, K
name: Bryder, D
name: Karlsson, S
name: Flygare, J
name: Debnath, S
name: Lindström, M S
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplasia caused by haploinsufficiency of genes encoding ribosomal proteins (RPs). Perturbed ribosome biogenesis in DBA has been shown to induce a p53-mediated ribosomal stress response. However, the mechanisms of p53 activation and its relevance for the erythroid defect remain elusive. Previous studies have indicated that activation of p53 is caused by the inhibition of mouse double minute 2 (Mdm2), the main negative regulator of p53, by the 5S ribonucleoprotein particle (RNP). Meanwhile, it is not clear whether this mechanism solely mediates the p53-dependent component found in DBA. To approach this question, we crossed our mouse model for RPS19-deficient DBA with Mdm2C305F knock-in mice that have a disrupted 5S RNP–Mdm2 interaction. Upon induction of the Rps19 deficiency, Mdm2C305F reversed the p53 response and improved expansion of hematopoietic progenitors in vitro, and ameliorated the anemia in vivo. Unexpectedly, disruption of the 5S RNP–Mdm2 interaction also led to selective defect in erythropoiesis. Our findings highlight the sensitivity of erythroid progenitor cells to aberrations in p53 homeostasis mediated by the 5S RNP–Mdm2 interaction. Finally, we provide evidence indicating that physiological activation of the 5S RNP-Mdm2-p53 pathway may contribute to functional decline of the hematopoietic system in a cell-autonomous manner over time.
Brexit e accordi di riammissione dell’Unione europea
Creators: name: Cellamare, Giovanni
Publisher: name: Universita' degli Studi di Salerno
Year: 2021
Subjects: Lisbon Treaty
Differentiated position of the United Kingdom
Irregular migrants
EU readmission agreements
Brexit

description: The effects of Brexit on the application of the EU readmission agreements can be examined first from the point of view of the relationship between the UK and the Member States. With regard to the readmission of citizens of Member States and the UK in their mutual relations, the readmission obligation deriving from general international law remains where the necessary conditions are met, given the absence of relevant agreements. As regards the relations with third States that are parties to the EU readmission agreements, the mentioned agreements will continue to be applied in the Member States, but could possibly no longer be applied in the UK, although the readmission obligation under customary international law continues to apply. The application to the UK of the content of the EC/EU readmission agreements could take place in the case of a manifestation of the coinciding will on the part of the UK and the third States that are interested in giving continuity to the application of said content, to the extent to which they wish to accept it. The relationship between the withdrawal of the UK and the application of the readmission clauses contained in agreements having a different object should be understood in light of the solution one chooses to give to the controversial problem of the effectiveness of those agreements for the UK after the withdrawal. That solution is affected by the multilateral or bilateral qualification of the agreement, as well as the notion of party accepted by the same agreement and the logicalsystematic connection of its clauses.
Muon-electron backward scattering: a prime example for endpoint singularities in SCET
Creators: name: Bell, Guido
name: Böer, Philipp
name: Feldmann, Thorsten
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We argue that energetic muon-electron scattering in the backward direction can be viewed as a template case to study the resummation of large logarithms related to endpoint divergences appearing in the effective-theory formulation of hard-exclusive processes. While it is known since the mid sixties that the leading double logarithms from QED corrections resum to a modified Bessel function on the amplitude level, the modern formulation in Soft-Collinear Effective Theory (SCET) shows a surprisingly complicated and iterative pattern of endpoint-divergent convolution integrals. In contrast to the bottom-quark induced $h \to γγ$ decay, for which a renormalized factorization theorem has been proposed recently, we find that rapidity logarithms generate an infinite tower of collinear-anomaly exponents. This can be understood as a generic consequence of the underlying $2\to 2$ kinematics. Using endpoint refactorization conditions for the collinear matrix elements, we show how the Bessel function is reproduced in the effective theory from consistency relations between quantities in a "bare" factorization theorem.
description: v2: Discussions in Sections 2.3 and 3.2 slightly modified. Conclusions unchanged. Matches published version
Generalized complex geometry of pure backgrounds in ten and eleven dimensions
Creators: name: Prins, Daniël
name: Tsimpis, Dimitrios
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Pure backgrounds are a natural generalization of supersymmetric Calabi-Yau compactifications in the presence of flux. They are described in the language of generalized SU(d) x SU(d) structures and generalized complex geometry, and they exhibit some interesting general patterns: the internal manifold is generalized Calabi-Yau, while the Ramond-Ramond flux is exact in a precise sense discussed in this paper. We have shown that although these two characteristics do persist in the case of generic ten-dimensional Euclidean type II pure backgrounds, they do not capture the full content of supersymmetry. We also discuss the uplift of real Euclidean type IIA pure backgrounds to supersymmetric backgrounds of Lorentzian eleven-dimensional supergravity.
description: 26 pages. Typos fixed, references added
PU.1-dependent regulation of UCH L1 expression in B-lymphoma cells
Creators: name: Gullapalli, Anuradha
name: Bheda, Anjali
name: Yue, Wei
name: Pagano, Joseph S.
name: Shackelford, Julia
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Elevated levels of ubiquitin C-terminal hydrolase L1 (UCH L1) have been detected in a variety of malignancies, and recent studies show the oncogenic capacity of overexpressed UCH L1 in vivo in animal models. Here we demonstrate that expression of endogenous UCH L1 is significantly higher in B-lymphoma cells than in transformed cells of epithelial and fibroblastic origin. The specific hematopoietic transcription factor PU.1 induces UCH L1 expression through direct activation of the uch l1 promoter. Using chromatin immunoprecipitation (ChIP) assays and direct mutagenesis we identified PU.1 binding sites on the uch l1 promoter, at least three of which are involved in this activation. We also show that the viral transcriptional co-activator EBNA2 dramatically increases PU.1-dependent up-regulation of endogenous UCH L1 expression. Finally, inhibition of PU.1 expression with specific shRNA resulted in reduction of UCH L1 mRNA and protein levels in Epstein–Barr virus (EBV)-transformed B-cells. We propose that the ubiquitin-editing enzyme UCH L1 is a multifunctional pro-oncogenic factor involved in development and progression of certain lymphoid malignancies, including EBV-associated lymphomas.
Regularization Theory of the Analytic Deep Prior Approach
Creators: name: Arndt, Clemens
Publisher: name: arXiv
Year: 2022
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: The analytic deep prior (ADP) approach was recently introduced for the theoretical analysis of deep image prior (DIP) methods with special network architectures. In this paper, we prove that ADP is in fact equivalent to classical variational Ivanov methods for solving ill-posed inverse problems. Besides, we propose a new variant which incorporates the strategy of early stopping into the ADP model. For both variants, we show how classical regularization properties (existence, stability, convergence) can be obtained under common assumptions.
RS resonance in di-final state production at the LHC to NLO+PS accuracy
Creators: name: Das, Goutam
name: Mathews, Prakash
name: Ravindran, V.
name: Seth, Satyajit
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We study the di-final state processes ($\ell^+ \ell^-$, $γγ$, $ZZ$, $W^+ W^-$) to NLO+PS accuracy, as a result of both the SM and RS Kaluza-Klein graviton excitations. Decay of the electroweak gauge boson final states to different leptonic states are included at the showering stage. A selection of the results has been presented with PDF and scale uncertainties for various distributions. Using the di-lepton and di-photon final states, we present the search sensitivity, for the $14$ TeV LHC at $50$ fb$^{-1}$ luminosity.
description: 20 pages, 14 figures
Quality of life domains among non-Hodgkin lymphoma survivors: an integrative literature review
Creators: name: Leak, Ashley
name: Smith, Sophia
name: Mayer, Deborah K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Survival rates of individuals with non-Hodgkin lymphoma (NHL) have increased in the past several years, as has the prevalence of older adults who are managing late and long-term effects of the disease and its treatment. In this integrative review, the state of the science for determining the quality of life (QOL) among NHL survivors is outlined. An online search of Medline, Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsycINFO, and the Cochrane Library databases was conducted using the following Keywords: non-Hodgkin lymphoma, health-related quality of life, quality of life, and impact of cancer. Eighteen studies published between 2000 and 2010 are reviewed. Of these, 17 were descriptive, cross-sectional designs, and one was a systematic review. The studies included participants of varying ages and years post-diagnosis as reported in several countries. Importantly, many used one or more QOL measures as outcome variables. Future research is needed on older and minority cancer populations and should include longitudinal and interventional studies.
Refining tumor-associated aneuploidy through ‘genomic recoding’ of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas
Creators: name: Bell, Jerold
name: Suter, Steven E.
name: Motsinger-Reif, Alison
name: Argyle, David
name: Thomas, Rachael
name: Lindblad-toh, Kerstin
name: Valli, Victor E.
name: Breen, Matthew
name: Borst, Luke
name: Modiano, Jaime F.
name: Kelley, Kathryn
name: Seiser, Eric L.
name: Burgess, Kristine
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Identification of the genomic regions most intimately associated with non-Hodgkin's lymphoma (NHL) pathogenesis is confounded by the genetic heterogeneity of human populations. We hypothesize that the restricted genetic variation of purebred dogs, combined with the contrasting architecture of the human and canine karyotypes, will increase the penetrance of fundamental NHL-associated chromosomal aberrations in both species. We surveyed non-random aneuploidy in 150 canine NHL cases, revealing limited genomic instability compared to their human counterparts and no evidence for CDKN2A/B deletion in canine B-cell NHL. ‘Genomic recoding’ of canine NHL data into a ‘virtual human’ chromosome format showed remarkably few regions of copy number aberration (CNA) shared between both species; restricted to regions of dog chromosomes 13 and 31, and human chromosomes 8 and 21. Our data suggest that gene discovery in NHL may be enhanced through comparative studies exploiting the less complex association between CNAs and tumor pathogenesis in canine patients.
Enrico Fermi and the Dolomites
Creators: name: Battimelli, Giovanni
name: De Angelis, Alessandro
Publisher: name: arXiv
Year: 2014
Subjects: subject: History and Philosophy of Physics (physics.hist-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Summer vacations in the Dolomites were a tradition among the professors of the Faculty of Mathematical and Physical Sciences at the University of Roma since the end of the XIX century. Beyond the academic walls, people like Tullio Levi-Civita, Federigo Enriques and Ugo Amaldi sr., together with their families, were meeting friends and colleagues in Cortina, San Vito, Dobbiaco, Vigo di Fassa and Selva, enjoying trekking together with scientific discussions. The tradition was transmitted to the next generations, in particular in the first half of the XX century, and the group of via Panisperna was directly connected: Edoardo Amaldi, the son of the mathematician Ugo sr., rented at least during two summers, in 1925 and in 1949, and in the winter of 1960, a house in San Vito di Cadore, and almost every year in the Dolomites; Enrico Fermi was a frequent guest. Many important steps in modern physics, in particular the development of the Fermi-Dirac statistics and the Fermi theory of beta decay, are related to scientific discussions held in the region of the Dolomites.
description: Proceedings of the conference "Cosmic ray origin: beyond the standard models", San Vito di Cadore (Dolomites, Italy), March 2014
CD40 ligand is necessary and sufficient to support primary diffuse large B-cell lymphoma cells in culture: a tool for in vitro preclinical studies with primary B-cell malignancies
Creators: name: Burnett, Robert C.
name: Breen, Matthew
name: Modiano, Jaime F.
name: Mason, Nicola J.
name: Williams, Christina
name: O’Brien, Timothy D.
name: Thomas, Rachael
name: Frantz, Aric M.
name: Avery, Anne C.
name: Ito, Daisuke
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Established cell lines are utilized extensively to study tumor biology and preclinical therapeutic development; however, they may not accurately recapitulate the heterogeneity of their corresponding primary disease. B-cell tumor cells are especially difficult to maintain under conventional culture conditions, limiting access to samples that faithfully represent this disease for preclinical studies. Here, we used primary canine diffuse large B-cell lymphoma to establish a culture system that reliably supports the growth of these cells. CD40 ligand, either expressed by feeder cells or provided as a soluble two-trimeric form, was sufficient to support primary lymphoma cells in vitro. The tumor cells retained their original phenotype, clonality and known karyotypic abnormalities after extended expansion in culture. Finally, we illustrate the utility of the feeder cell-free culture system for comparable assessment of cytotoxicity using dog and human B-cell malignancies. We conclude this system has broad applications for in vitro preclinical development for B-cell malignancies.
Newton maps as matings of cubic polynomials
Creators: name: Aspenberg, Magnus
name: Roesch, Pascale
Publisher: name: arXiv
Year: 2014
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 37F10, 37F20

description: In this paper we prove existence of matings between a large class of renormalizable cubic polynomials with one fixed critical point and another cubic polynomial having two fixed critical points. The resulting mating is a Newton map. Our result is the first part towards a conjecture by Tan Lei, stating that all (cubic) Newton maps can be described as matings or captures.
description: 15 figures
Phase II open label study of the oral vascular endothelial growth factor-receptor inhibitor PTK787/ZK222584 (vatalanib) in adult patients with refractory or relapsed diffuse large B-cell lymphoma
Creators: name: Gockerman, Jon
name: Shea, Thomas Charles
name: Brander, Danielle
name: Moore, Joseph O.
name: Rizzieri, David
name: Diehl, Louis
name: Beaven, Anne
name: Decastro, Carlos
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: PTK787/ZK222584 (Vatalanib), an orally active inhibitor of vascular endothelial growth factor receptors (VEGF-Rs), was evaluated in this phase II study of 20 patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL). Patients received once daily PTK787/ZK222584 at a target dose of 1250mg. Eighteen patients were evaluable for response: 1 patient had a complete response (CR), 6 patients had stable disease but subsequently progressed, 10 patients had progressive disease by 3 cycles, and 1 subject withdrew before response evaluation. The patient who attained a CR underwent autologous stem cell transplantation and remains disease free 76 months after study completion. There were no grade 4 toxicities. Grade 3 thrombocytopenia occurred in 20% and grade 3 hypertension occurred in 10%. There were no episodes of grade 3 proteinuria. In conclusion, PTK787/ZK222584 was well tolerated in a heavily pretreated population of DLBCL patients, though its therapeutic potential as a single agent in DLBCL appears limited.
Zidovudine-based lytic-inducing chemotherapy for Epstein–Barr virus-related lymphomas
Creators: name: Ashlock, Brittany
name: Diaz, Luis A.
name: Toomey, Ngoc
name: Dittmer, Dirk P.
name: Bayraktar, Ulas Darda
name: Pereira, Denise
name: Bayraktar, Soley
name: Cabral, Lisa
name: Ramos, Juan Carlos
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Treatment of Epstein–Barr virus (EBV)-related lymphomas with lytic-inducing agents is an attractive targeted approach for eliminating virus-infected tumor cells. Zidovudine (AZT) is an excellent substrate for EBV-thymidine kinase: it can induce EBV lytic gene expression and apoptosis in primary EBV+ lymphoma cell lines. We hypothesized that the combination of AZT with lytic-inducing chemotherapy agents would be effective in treating EBV+ lymphomas. We report a retrospective analysis of 19 patients with aggressive EBV+ non-Hodgkin lymphoma, including nine cases of acquired immune deficiency syndrome-associated primary central nervous system lymphoma (AIDSPCNSL) treated with AZT-based chemotherapy. Our results demonstrate that high-dose AZT–methotrexate is efficacious in treating highly aggressive systemic EBV+ lymphomas in the upfront setting. In primary EBV+ lymphoma cell lines, the combination of AZT with hydroxyurea resulted in synergistic EBV lytic induction and cell death. Further, AZT–hydroxyurea treatment resulted in dramatic responses in patients with AIDSPCNSL. The combination of AZT with chemotherapy, especially lytic-inducing agents, should be explored further in clinical trials for the treatment of EBV-related lymphomas.
Determinants of sensitivity of human T-cell leukemia CCRF-CEM cells to immucillin-H
Creators: name: Schramm, Vern L.
name: Huang, Min
name: Noel, Karen
name: Yang, Jing
name: Mitchell, Beverly S.
name: Gu, Jingjin
name: Graves, Lee M.
name: Wang, Yanhong
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Immucillin-H (BCX-1777, forodesine) is a transition state analogue and potent inhibitor of PNP that shows promise as a specific agent against activated human T-cells and T-cell leukemias. The immunosuppressive or antileukemic effects of Immucillin-H (ImmH) require co-administration with deoxyguanosine (dGuo) to attain therapeutic levels of intracellular dGTP. In this study we investigated the requirements for sensitivity and resistance to ImmH and dGuo. 3H-ImmH transport assays demonstrated that the equilibrative nucleoside transporters (ENT1 and ENT2) facilitated the uptake of ImmH in human leukemia CCRF-CEM cells whereas 3H-dGuo uptake was primarily dependent upon concentrative nucleoside transporters (CNTs). Analysis of lysates from an ImmH-resistant CCRF-CEM-AraC-8D cells demonstrated undetectable deoxycytidine kinase (dCK) activity, suggesting that dCK and not deoxyguanosine kinase (dGK) was the rate-limiting enzyme for phosphorylation of dGuo in these cells. Examination of ImmH cytotoxicity in a hypoxanthine-guanine phosphoribosyltransferase (HGPRT)-deficient cell line CCRF-CEM-AraC-8C, demonstrated enhanced sensitivity to low concentrations of ImmH and dGuo. RT-PCR and sequencing of HGPRT from the HGPRT-deficient CCRF-CEM-AraC-8C cells identified an Exon 8 deletion mutation in this enzyme. Thus these studies show that specific nucleoside transporters are required for ImmH cytotoxicity and predict that ImmH may be more cytotoxic to 6-thioguanine (6-TG) or 6-thiopurine-resistant leukemia cells caused by HGPRT deficiency.
Lepton flavor violation within the Simplest Little Higgs model
Creators: name: Ramirez, Enrique
name: Roig, Pablo
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We carry out an exhaustive analysis of lepton flavor violating processes within the Simplest Little Higgs model. Its discovery could be expected from either $μ\to e$ conversion in nuclei, $μ\to eγ$ or $μ\to3e$ decays. Then, the tau sector could help discriminating this model not only via $τ\to\ellγ$ ($\ell=μ,e$) and $τ\to3\ell$ decays, but also by means of $\ell\toτ$ conversion in nuclei, which is promising in this respect. Although the model violates slightly custodial symmetry, acommodating the recent CDF $M_W$ measurement is in tension with electroweak precision data.
description: 50 pages, 21 figures. Minor changes to match the version accepted for publication in PRD. arXiv admin note: text overlap with arXiv:1101.2936 by other authors
Guanine nucleotide depletion inhibits pre-ribosomal RNA synthesis and causes nucleolar disruption
Creators: name: Zhang, Yanping
name: Ji, Yanshan
name: Mitchell, Beverly
name: Huang, Min
name: Itahana, Koji
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Inosine monophosphate dehydrogenase (IMPDH) is a pivotal enzyme in the de novo pathway of guanine nucleotide biosynthesis. Inhibitors of this enzyme decrease intracellular guanine nucleotide levels by 50-80% and have potential as anti-neoplastic agents. Both mycophenolic acid (MPA) and AVN-944 are highly specific inhibitors of IMPDH that cause cell cycle arrest or apoptosis in lymphocytes and leukemic cell lines. We have examined the mechanisms by which these two agents cause cytotoxicity. Both MPA and AVN-944 inhibit the growth of K562 cells, and induce apoptosis in Raji B and CCRF-CEM T cells. Both compounds strikingly inhibit RNA synthesis within 2 h of exposure. Depletion of guanine nucleotides by MPA and AVN-944 also causes an early and near-complete reduction in levels of the 45S precursor rRNA synthesis and the concomitant translocation of nucleolar proteins including nucleolin, nucleophosmin, and nucleostemin from the nucleolus to the nucleoplasm. This efflux correlates temporally with the sustained induction of p53 in cell lines with wild type p53. We conclude that inhibition of IMPDH causes a primary reduction in rRNA synthesis and secondary nucleolar disruption and efflux of nucleolar proteins that most likely mediate cell cycle arrest or apoptosis. The ability of AVN-944 to induce apoptosis in a number of leukemic cell lines supports its potential utility in the treatment of hematologic malignancies.
Cosmological Simulations of Decaying Dark Matter: Implications for Small-scale Structure of Dark Matter Halos
Creators: name: Wang, Mei-Yu
name: Peter, Annika H. G.
name: Strigari, Louis E.
name: Zentner, Andrew R.
name: Arant, Bryan
name: Garrison-Kimmel, Shea
name: Rocha, Miguel
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present a set of N-body simulations of a class of models in which an unstable dark matter particle decays into a stable non-interacting dark matter particle, with decay lifetime comparable to the Hubble time. We study the effects of the kinematic recoil velocity received by the stable dark matter on the structures of dark matter halos ranging from galaxy-cluster to Milky Way mass scales. For Milky Way-mass halos, we use high-resolution, zoom-in simulations to explore the effects of decays on Galactic substructure. In general, halos with circular velocities comparable to the magnitude of kick velocity are most strongly affected by decays. We show that decaying dark matter models with lifetimes comparable to Hubble time and recoil speeds about 20-40 km/s can significantly reduce both the abundance of Galactic subhalos and the internal densities of the subhalos. We also compare subhalo circular velocity profiles with observational constraints on the Milky Way dwarf satellite galaxies. Interestingly, we find that decaying dark matter models that do not violate current astrophysical constraints, can significantly mitigate both the well-documented "missing satellites problem" and the more recent "too big to fail problem" associated with the abundances and densities of Local Group dwarf satellite galaxies. A relatively unique feature of late decaying dark matter models is that they predict significant evolution of halos as a function of time. This is an important consideration because at high redshifts, prior to decays, decaying models exhibit the same sequence of structure formation as cold dark matter. We conclude that models of decaying dark matter make predictions that are relevant for the interpretation of observations of small galaxies in the Local Group and can be tested or constrained by the kinematics of Local Group dwarf galaxies as well as by forthcoming large-scale surveys.
description: 17 pages, 14 figures, references added, labels added in figure 1 & 2, submitted to MNRAS
Co-existence of size-dependent and size-independent thermal conductivities in single layer black phosphorus
Creators: name: Zhu, Liyan
name: Zhang, Gang
name: Li, Baowen
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Thermal conductivity of single layer black phosphorus (BP) is investigated by combining density functional calculations and Peierls-Boltzmann transport equation. Differing from isotropic and divergent thermal conductivities in two-dimensional graphene and MoS$_2$, an compelling co-existence of size-dependent and size-independent thermal conductivities are discovered for single layer BP along zigzag (ZZ) and armchair (AM) direction, respectively. Besides, thermal conductivities in single layer BP are found to be highly anisotropic because of orientation dependent group velocities, e.g., thermal conductivities at 300 K are 83.5 and 24.3 W/m-K along ZZ and AM directions for single layer BP with a size of 10 $μm$, respectively.
description: 8 pages, 7 figures;reference updated
Entanglement, Coherence, and Extractable Work in Quantum Batteries
Creators: name: Shi, Hai-Long
name: Ding, Shu
name: Wan, Qing-Kun
name: Wang, Xiao-Hui
name: Yang, Wen-Li
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We investigate the connection between quantum resources and extractable work in quantum batteries. We demonstrate that quantum coherence in the battery or the battery-charger entanglement is a necessary resource for generating nonzero extractable work during the charging process. At the end of the charging process, we also establish a tight link of coherence and entanglement with the final extractable work: coherence naturally promotes the coherent work while coherence and entanglement inhibit the incoherent work. We also show that obtaining maximally coherent work is faster than obtaining maximally incoherent work. Examples ranging from the central-spin battery and the Tavis-Cummings battery to the spin-chain battery are given to illustrate these results.
description: 6+1 pages, 2 figures
Core-shell enhanced single particle model for LiFePO$_4$ batteries
Creators: name: Takahashi, Aki
name: Pozzato, Gabriele
name: Allam, Anirudh
name: Azimi, Vahid
name: Li, Xueyan
name: Lee, Donghoon
name: Ko, Johan
name: Onori, Simona
Publisher: name: arXiv
Year: 2022
Subjects: subject: Systems and Control (eess.SY)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In this paper, a novel electrochemical model for LiFePO$_4$ battery cells that accounts for the positive particle lithium intercalation and deintercalation dynamics is proposed. Starting from the enhanced single particle model, mass transport and balance equations along with suitable boundary conditions are introduced to model the phase transformation phenomena during lithiation and delithiation in the positive electrode material. The lithium-poor and lithium-rich phases are modeled using the core-shell principle, where a core composition is encapsulated with a shell composition. The coupled partial differential equations describing the phase transformation are discretized using the finite difference method, from which a system of ordinary differential equations written in state-space representation is obtained. Finally, model parameter identification is performed using experimental data from a 49Ah LFP pouch cell.