cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: assiette A3 (Barrier  Luginbühl 2021)
Creators: name: Barrier, Sylvie
name: Luginbühl, Thierry
Publisher: name: Conservatoire National des Données 3D (CND3D)
Year: 2024
Subjects: subject: assiette
subject: Artefact
subject: ACQUISITION

description: Modèle 3D
El Maltés de Madrid: Digital edition
Creators: name: Miguel, Betti
name: Leblanc Elina
Publisher: name: Zenodo
Year: 2021
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2022), led by the professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
New draftWhat Landau did not know about the theory of liquids
Creators: name: Pratt, Lawrence
Publisher: name: figshare
Year: 2016
Subjects: subject: 20405 Soft Condensed Matter
subject: FOS: Physical sciences

description: Slides from a talk at the Chemical & Biomolecular Engineering Department, Rice University, October 15, 2015 p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 8.0px Helvetica} p.p2 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Helvetica}
Context-specific action of macrolide antibiotics on the eukaryotic ribosome
Creators: name: Svetlov, Maxim S
name: Koller, Timm O
name: Meydan, Sezen
name: Shankar, Vaishnavi
name: Klepacki, Dorota
name: Polacek, Norbert
name: Guydosh, Nicholas R
name: Vázquez-Laslop, Nora
name: Wilson, Daniel N
name: Mankin, Alexander
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: Uncategorized

description: Macrolide antibiotics bind in the nascent peptide exit tunnel of the bacterial ribosome and prevent polymerization of specific amino acid sequences, selectively inhibiting translation of a subset of proteins. Because preventing translation of individual proteins could be beneficial for the treatment of human diseases, we asked whether macrolides, if bound to the eukaryotic ribosome, would retain their context- and protein-specific action. By introducing a single mutation in rRNA, we rendered yeast Saccharomyces cerevisiae cells sensitive to macrolides. Cryo-EM structural analysis showed that the macrolide telithromycin binds in the tunnel of the engineered eukaryotic ribosome. Genome-wide analysis of cellular translation and biochemical studies demonstrated that the drug inhibits eukaryotic translation by preferentially stalling ribosomes at distinct sequence motifs. Context-specific action markedly depends on the macrolide structure. Eliminating macrolide-arrest motifs from a protein renders its translation macrolide-tolerant. Our data illuminate the prospects of adapting macrolides for protein-selective translation inhibition in eukaryotic cells.
title: Synthesis and self-assembly of DNA-β turn Conjugates
Creators: name: Taylor, Emerald Rhiannon
Publisher: name: University of Kent
Year: 2024

description: This thesis discusses the synthesis and self-assembly of several DNA-peptide conjugates, through different bi-orthogonal conjugating methods. Chapter 1 explores the current literature and perspective for which this work is based. Chapter 2 discusses the synthesis of DNA by solid phase synthesis, before being modified with a maleimide based phosphoramidite. The chapter goes on to discuss the development of these methods. Commercially bought DNA was modified with two bi-functional crosslinkers, before being further modified with different peptides. The chapter discusses the full scale of method development to obtain DNA-peptide conjugates, including the first known example of DNA β turn conjugates in the literature.
Chapters 3-5 discusses the self-assembly of DNA-peptide conjugates, with peptide directed, DNA and peptide directed, and DNA directed self-assembly respectively. Chapter 3, peptide driven assembly is explored through the doping of the parent peptide ILVAGK with varying amounts of DNA-ILVAGK. These experiments were observed over 28 days, and the resultant structures analysed by atomic force microscopy. In Chapter 4, both peptide and DNA driven self-assembly of DNA-ILVAGK is studied through DNA hybridisation with complementary sequences of 1, 2, and 3 lengths. As in Chapter 3, these studies were supported by atomic force microscopy, dynamic light scattering and circular dichroism. The structures observed in Chapter 4 differed in timeline and type to those seen in Chapter 3. Chapter 5 investigates DNA driven self-assembly with the peptide assembly disabled using sodium dodecyl sulphate. The structures observed during 28 days of aging showed little change in morphology over the period. This is indicative of the presence of hierarchy within this system.
Chapter 6 consists of an overall conclusion, to draw together the individual conclusions drawn in each chapter.
El Maltés de Madrid: Digital edition
Creators: name: Miguel, Betti
name: Leblanc Elina
Publisher: name: Zenodo
Year: 2022
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2022), led by the professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Python Partners: Making Things Better by Working Together!
Creators: name: Lewis, Ronald
name: Mitchell, Jason
Publisher: name: Loyola Marymount University
Year: 2023
Subjects: Python
Open Educational Resources
Automation
Collaborative learning

description: Titled "Python Partners," this presentation was presented at the Statewide California Electronic Library Consortium Annual Conference in March 2023. It outlines the learning journey of the Acquisitions & Collection Development Department at the William H. Hannon Library, Loyola Marymount University.

Through collaborative learning sessions, librarians and staff explored Python programming, using open educational resources and their existing knowledge. They automated tasks, streamlined workflows, and improved service quality.

The presentation shares their learning experience and highlights the benefits of using open educational resources for librarian professional development.
Ferramenta da Terapia de Aceitação e Compromisso (ACT): Exercício de Identificação e Definição de Pensamentos Automáticos
Creators: name: Brandl, Edenilson
Publisher: name: Zenodo
Year: 2024
Subjects: Ferramenta da Terapia de Aceitação e Compromisso (ACT)
Terapia de Aceitação e Compromisso (ACT)
Exercício de Identificação e Definição de Pensamentos Automáticos
Enciclopédia da Conscienciologia

description: Definologia: O Exercício de Identificação e Definição de Pensamentos Automáticos é uma ferramenta da Terapia de Aceitação e Compromisso (ACT) empregada para auxiliar o indivíduo a reconhecer e categorizar os pensamentos automáticos que emergem em sua mente, promovendo a conscientização e a desidentificação com esses conteúdos mentais.
A La Recherche Du Tigre Perdu, Contre Sainte-Beuve re-constructing the possibilities in 'Evidence of Me ...'
Creators: name: McKemmish, Sue
name: Upward, Frank
Publisher: name: Monash University
Year: 2016
Subjects: Uncategorized

description: No description supplied
Archives & Manuscripts, vol. 29, no. 1, p. 22-43
title: assiette A2b (Barrier  Luginbühl 2021)
Creators: name: Luginbühl, Thierry
name: Barrier, Sylvie
Publisher: name: Conservatoire National des Données 3D (CND3D)
Year: 2024
Subjects: subject: assiette
subject: Artefact
subject: ACQUISITION

description: Modèle 3D
title: 34 – Entretien avec l’azmari Admasu Eräta
Creators: name: Wion, Anaïs
name: Bolay, Anne
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: A propos d’un azmari nommé Melkiyē.
title: jatte E11c (Barrier  Luginbühl 2021)
Creators: name: Luginbühl, Thierry
name: Barrier, Sylvie
Publisher: name: Conservatoire National des Données 3D (CND3D)
Year: 2024
Subjects: subject: jatte
subject: Artefact
subject: ACQUISITION

description: Modèle 3D
Upscaling collaboration between academic and public libraries for CeOS in SE Europe
Creators: name: Mumelaš, Dolores
name: Martek, Alisa
name: Mučnjak, Dorja
Publisher: name: Zenodo
Year: 2022
Subjects: citizen science
open science
libraries

description: This study looks at methods of upscaling the collaboration between academic and public libraries in coordinating citizen science activities, through case studies from across Europe.

 

Read more about the CeOS_SE project on our website: https://ceosse-project.eu/
Ferramenta da Terapia de Aceitação e Compromisso (ACT): Prática de Reconhecer e Aceitar a Vulnerabilidade
Creators: name: Brandl, Edenilson
Publisher: name: Zenodo
Year: 2024
Subjects: Ferramenta da Terapia de Aceitação e Compromisso (ACT)
Terapia de Aceitação e Compromisso (ACT)
Prática de Reconhecer e Aceitar a Vulnerabilidade
Enciclopédia da Conscienciologia

description: Definologia: A Prática de Reconhecer e Aceitar a Vulnerabilidade é uma ferramenta da Terapia de Aceitação e Compromisso (ACT) utilizada para auxiliar o indivíduo a conscientizar-se e acolher sua condição de vulnerabilidade emocional, permitindo uma relação mais saudável e compassiva consigo mesmo e com o ambiente circundante.
Niche size analysis
Creators: name: Biederman, Lori
Publisher: name: figshare
Year: 2016
Subjects: subject: 60705 Plant Physiology
subject: FOS: Biological sciences
subject: Plant Biology
subject: 60202 Community Ecology (excl. Invasive Species Ecology)

description: This document is an overview of an analysis done as part of the manuscript "Nutrient addition shifts community flowering phenology in North American Prairies" and it did not fit with the final version. However I had done the analysis and wanted to report my findings.
The church of St. Alkmund, Derby.
Creators: name: Radford, C A Raleigh
Publisher: name: Archaeology Data Service
Year: 2008

description: The Derbyshire Archaeological Journal, 96, 26-61
description: Excavation following the destruction of a city centre church revealed four periods of medieval structure, the earliest being pre-Conquest. The development of the plan is discussed; the significance and dating of thirteen sculptured stones found in this and previous clearance is assessed. High quality carving upon one sarcophagus supports the argument that it was the 9th century shrine of St Alkmund. The life of that saint and the status of the church are examined. L A S B
title: bol B6a (Barrier  Luginbühl 2021)
Creators: name: Luginbühl, Thierry
name: Barrier, Sylvie
Publisher: name: Conservatoire National des Données 3D (CND3D)
Year: 2024
Subjects: subject: bol
subject: Artefact
subject: ACQUISITION

description: Modèle 3D
title: 13 – Entretien avec l’azmari Tadäsä : une vieille chanson de Belay Zelleqe
Creators: name: Wion, Anaïs
name: Bolay, Anne
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Une vieille chanson de Belay Zelleqe.
title: bol B18 (Barrier  Luginbühl 2021)
Creators: name: Luginbühl, Thierry
name: Barrier, Sylvie
Publisher: name: Conservatoire National des Données 3D (CND3D)
Year: 2024
Subjects: subject: bol
subject: Artefact
subject: ACQUISITION

description: Modèle 3D
Ferramenta da Terapia Interpessoal (TIP): Técnica de Geração de Alternativas
Creators: name: Brandl, Edenilson
Publisher: name: Zenodo
Year: 2024
Subjects: Ferramenta da Terapia Interpessoal (TIP)
Terapia Interpessoal (TIP)
Técnica de Geração de Alternativas
Enciclopédia da Conscienciologia

description: Definologia: A Técnica de Geração de Alternativas é uma ferramenta da Terapia Interpessoal (TIP) utilizada para auxiliar o indivíduo na identificação e desenvolvimento de opções e estratégias de enfrentamento diante de situações interpessoais desafiadoras.
Cytotoxic Effect of Latanoprost on Human Corneal Stromal Cells in vitro and its Possible Mechanisms
Creators: name: Shen, Jun-Wei
name: Shan, Ming
name: Peng, Yuan-Yuan
name: Ting-Jun Fan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 60506 Virology

description: Purpose: To investigate the cytotoxic effect of latanoprost on corneal stroma and its underlying cellular and molecular mechanisms using non-transfected human corneal stromal (HCS) cells as an in vitro model. Methods: After HCS cells were treated with latanoprost at concentrations varying from 50 mg/l (clinical therapeutic dosage) to 0.78125 mg/l, and cell morphology, cell viability, and cell cycle were detected by light microscopy, methyl thiazolyl tetrazolium assay, and flow cytometry (FCM) with propidium iodide (PI) staining, respectively. Meanwhile, alterations in plasma membrane permeability, phosphatidylserine (PS) orientation, DNA integrality, and cell ultrastructure were examined by acridine orange (AO)/ethidium bromide (EB) double staining, FCM with Annexin-V/propidium iodide (PI) staining, DNA electrophoresis, and transmission electron microscopy. Furthermore, caspase activation, mitochondrial transmembrane potential (MTP), and expression of pro-apoptotic regulators were determined by ELISA, FCM with 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethybenzimida (JC-1) staining, and Western blot, respectively. Results: Latanoprost above concentrations of 3.125 mg/l can induce dose- and time-dependent morphological abnormality, growth retardation, viability decline, and plasma membrane permeability elevation of HCS cells. Moreover, latanoprost can arrest the cell cycle of these cells at S phase and induce PS externalization, DNA fragmentation, and apoptotic body formation of the cells. Furthermore, latanoprost can induce activation of caspase-3, -8 and -9; disruption of MTP; downregulation of anti-apoptotic Bcl-2; upregulation of pro-apoptotic Bax; and cytoplasmic cytochrome c release. Conclusions: Latanoprost above and at 3.125 mg/l (1/16 of its clinical therapeutic dosage) has a dose- and time-dependent cytotoxicity to HCS cells by inducing death receptor-mediated mitochondria-dependent apoptosis, which should be used with great caution in clinical situations to avoid undesired damages to HCS cells.
The origin of the new market of Chesterfield.
Creators: name: Riden, Philip
Publisher: name: Archaeology Data Service
Year: 2008

description: The Derbyshire Archaeological Journal, 97, 5-15
description: The most important change to the medieval layout of the town derived from the building of the new market, here argued on historical grounds as taking place between 1165 and 1199 rather than in 13th century.
title: 28 – Entretien avec l’azmari Admasu Eräta : azmari et batailles
Creators: name: Wion, Anaïs
name: Bolay, Anne
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: sanga
subject: chant de guerre
valueUri: ark:/12148/cb11945385x

description: Différence entre les chants de guerre shäläla et sanga. Noms d’azmari qui jouèrent pour les ras pendant l’occupation italienne.
Beyond BRITE - Expanding Bright Star Research through Kepler and TESS
Creators: name: Antoci, Victoria
Publisher: name: Zenodo
Year: 2024

description: Since the launch of the BRITE constellation, the field of bright star observations has experienced transformative changes. This talk will delve into the complementary roles of NASA's TESS and the Kepler missions in observing bright stars. Emphasis will be placed on types of variability, such as pulsations, rotational modulations, and binary systems, which have been studied extensively using BRITE. I will discuss the significant findings from these missions and explore their implications for future research and potential missions. 
description: Funding Information:Funded by the European Union (ERC, MAGNIFY, Project 101126182 ). Views and opinions expressed are however those of the author only and do not necessarily reflect those of the European Union or the European Research Council. Neither the European Union nor the granting authority can be held responsible for them.
DFT study on gas-phase hydrodeoxygenation of guaiacol by various reaction schemes
Creators: name: Verma, Anand Mohan
name: Kishore, Nanda
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Inorganic Chemistry
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Guaiacol is an important phenolic component present in pyrolytic bio-oils; and in this work its hydrodeoxygenation (HDO) by various reaction schemes has been considered within the framework of density functional theory. In this computational study, primarily three reaction schemes for the HDO of guaiacol are considered. In the first reaction scheme (RS 1), guaiacol undergoes hydrogenolysis at O–CH3 bond site of methoxy group to produce catechol and methane followed by HDO of catechol forming phenol and water, followed by HDO of phenol producing benzene and water and finally benzene leading to cyclohexane formation. In the second reaction scheme (RS 2), guaiacol undergoes hydrogenolysis at Caromatic–O bond of methoxy group producing phenol and methanol followed by hydrotreatment of phenol to form cyclohexane along with same intermediates as in the first reaction scheme. In the third reaction scheme (RS 3), HDO of guaiacol compound at Caromatic–OH sigma bond produces anisole and water; and then anisole follows two secondary pathways to produce cyclohexane. In this computational study, the transition state optimisations, vibrational frequency and IRC calculations are carried out by B3LYP functional with 6-311+g(d,p) basis set using Gaussian 09 and Gauss View 5 software package.
Biografien/Chroniken der (Co-)Radikalisierung: Befunde erster Analysen und Erkundungen des Forschungsfeldes
Creators: name: Uslucan, Haci-Halil
name: Kiefer, Michael
name: Mücke, Marvin
name: Kaya, Fatih
Publisher: name: Universität Osnabrück
Year: 2024
Subjects: subject: Radikalisierung
subject: Prävention
subject: Co-Radikalisierung
subject: Extremismus
subject: Diskriminierung
subject: 300 - Sozialwissenschaften, Soziologie, Anthropologie

description: Das vorliegende Working Paper 3 ist die dritte Fassung einer Reihe von Working Papers des Projektes „Radikaler Islam – Radikaler Anti-Islam. Gesellschaftliche Polarisierung und wahrgenommene Bedrohungen als Triebfaktoren von Radikalisierungs- und Co- Radikalisierungsprozessen bei Jugendlichen und Post-Adoleszenten“ (RIRA).
Urban ants of the city of Buenos Aires, Argentina: species survey and practical control
Creators: name: Josens, Roxana
name: Sola, Francisco
name: Lois-Milevicich, Jimena
name: Mackay, William
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Ants are among the most diverse, abundant and ecologically significant organisms on earth. They have colonized almost all existing habitats, including urban areas, where they may pose serious problems for human activities. Here, we present different aspects of our studies on urban ants in the city of Buenos Aires aimed at collecting information on the species present in the city and at improving bait control strategies via laboratory assays. The use of these baits represents a control strategy that is environment-friendly as it avoids indiscriminate pesticide release. Moreover, we show that our baits exhibit higher efficiency when compared to a commercial bait, as it is optimized in terms of the ants’ feeding behavior even when both have the same active compound and at the same concentration. This work represents the first integrative study on urban ants in the city of Buenos Aires and indicates that the control of invasive species in urban settings may be improved by increasing the scientific knowledge of the biology of the target species.
title: 02 – Entretien avec l’azmari Tadäsä : chant
Creators: name: Wion, Anaïs
name: Bolay, Anne
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Chant
title: 10 – Entretien avec l’azmari Tadäsä : chant
Creators: name: Wion, Anaïs
name: Bolay, Anne
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: chant

description: Chant
Optimization by moving ridge functions: derivative-free optimization for computationally intensive functions
Creators: name: Gross, James C.
name: Parks, Geoffrey T.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: Space Science
Medicine
Neuroscience
Information Systems not elsewhere classified
Mathematical Sciences not elsewhere classified

description: A novel derivative-free algorithm, called optimization by moving ridge functions (OMoRF), for unconstrained and bound-constrained optimization is presented. This algorithm couples trust region methodologies with output-based dimension reduction to accelerate convergence of model-based optimization strategies. The dimension-reducing subspace is updated as the trust region moves through the function domain, allowing OMoRF to be applied to functions with no known global low-dimensional structure. Furthermore, its low computational requirement allows it to make rapid progress when optimizing high-dimensional functions. Its performance is examined on a set of test problems of moderate to high dimension and a high-dimensional design optimization problem. The results show that OMoRF compares favourably with other common derivative-free optimization methods, even for functions in which no underlying global low-dimensional structure is known.
title: Materialität der Erinnerung
Creators: name: Querner, Lisa
Publisher: name: ZZF - Leibniz-Zentrum für Zeithistorische Forschung: Visual History
Year: 2024

description: 31 weiße Seiten aus dickem Papier, hochkant nahezu quadratisch, getrennt durch ebenfalls weißes Pergaminpapier, sind eingebunden in mittelbraunen, glatten Kunststoff, welcher einen Ledereinband imitieren soll. Das Album der Familie Lindenberger ist relativ klein: 25 cm hoch, aufgeklappt 45 cm breit und knapp 5 cm dick. 99 Schwarz-Weiß-Bilder in unterschiedlichen Formaten sind vorder- und rückseitig fest eingeklebt auf Seiten – ein Teil der Seiten bleibt leer. Die meisten Bilder sind Einzelabzüge, seltener sind zwei Fotos als Doppelabzüge auf einer Pappe. Die Fotos sind eine Mischung aus professionell aufgenommenen Bildern, wie die Logos der Fotografen am Fotorand zeigen, und spontaneren, selbst gemachten Aufnahmen.
DOPA-based paclitaxel-loaded liposomes with modifications of transferrin and alendronate for bone and myeloma targeting
Creators: name: Chang, Qing
name: Geng, Rui
name: Shanzheng Wang
name: Qu, Ding
name: Xiangfei Kong
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Hematology

description: Treatment for multiple myeloma (MM) with a combined strategy of bone and tumor targeting remains a crucial technical challenge due to the incorporation of various functional components into one single system. Here, we developed dioleoyl phosphatidic acid (DOPA)-based paclitaxel (PTX)-loaded liposomes with modifications of alendronate and transferrin (Ald-/Tf-modified PTX-L), which were capable of bone affinity mediated by phosphate groups in DOPA and alendronate, and tumor targeting offered by transferrin. Ald-/Tf-modified PTX-L had clear and well-defined spherical shape with an intermediated size of 118.8 ± 4.8 nm, a highly negative surface charge of −46.9 ± 6.8 mV and a drug entrapment efficiency (DEE) of approximately 80%. When the pH was changed from pH 7.4 to pH 6.5, the accumulative release of PTX from Ald-/Tf-modified PTX-L significantly increased from 26.7 ± 3.7% to 41.7 ± 4.9%. Importantly, liposomes based on DOPA displayed an obviously stronger affinity with hydroxyapatite (HAp) than 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE)-based liposomes. Compared to PTX-L, Ald-/Tf-modified PTX-L exhibited obvious improvement of cytotoxicity (IC50 = 1.25 ± 0.09 μg/mL), significant enhancement on PTX intracellular accumulation (16.58 ± 0.62 μg/mg) and notable promotion to apoptosis induction (45.21 ± 3.10%) toward myeloma (MM1s) cells. In this study of antitumor efficacy, Ald-/Tf-modified PTX-L with bone-specific targeting showed a significant effect on extending the median survival time (48 days) and terminal survival time (> 58 days) against the MM1S-injected nude mice among all formulations. The results suggested that Ald-/Tf-modified PTX-L had potential as an efficient anticancer drug delivery system for MM therapy.
Time–cost trade-off in a multi-choice assignment problem
Creators: name: Singh, Shalabh
name: Singh, Sonia
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: The conventional assignment problem is unable to handle scenarios that may arise due to different working modes of machines leading to multiple cost and time entries corresponding to a job–machine pair. The present article deals with this problem and models it as a multi-choice bi-objective assignment problem, the two objectives being assignment cost and bottleneck time. Two different solution procedures are presented based on the Decision-Maker's (DM's) preference structure. First, when the DM provides his/her preference structure as goals, a solution methodology is proposed using goal programming and its different multi-choice variants. In the second case, when no preference is provided by the DM, a two-step approach is presented that iteratively solves a multi-choice cost-minimizing assignment problem to obtain all Pareto-optimal time–cost pairs and finally, based on the Technique for Order Preference by Similarity to the Ideal Solution (TOPSIS), a single efficient pair is obtained. The algorithm is successfully implemented using the CPLEX® optimization package and tested on various test problems.
title: 15 – Entretien avec l’azmari Tadäsä : chant et bavardages
Creators: name: Wion, Anaïs
name: Bolay, Anne
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Chants et bavardages des clients dans l’arake bet.
title: The Use of Rhythm in the Acquisition of Motor Skills
Creators: name: Fulop, Ann C.
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 1989

description: This research assessed whether rhythm aids in the acquisition of motor skills by providing cues for the timing of those skills. The nature of representations of rhythms in memory was also explored. Certain rhythms have stable memory representations, while others have unstable representations. It was hypothesized that rhythms that had stable memory representations would be more beneficial in learning a skill than unstable rhythms. Three groups learned three different rhythms by practicing a tracking task. Three different tracks displayed the three rhythms. Following training, subjects attempted to reproduce the rhythms from memory. The results suggest that rhythms do help in learning motor skills, but stable rhythms are not superior to unstable rhythms.
Paleoglaciation on opposite flanks of the Ikh-Turgen Mountains - Supplementary dataset
Creators: name: Blomdin, Robin
Publisher: name: figshare
Year: 2016
Subjects: subject: 40601 Geomorphology and Regolith and Landscape Evolution
subject: FOS: Earth and related environmental sciences
subject: Physical Geography

description: This document describes the extended methodology and supplementary data of the manuscript "Paleoglaciation on opposite flanks of the Ikh-Turgen Mountains, Central Asia: Importance of style of moraine deposition for 10-Be surface exposure dating" by Blomdin et al., Paper II in the PhD thesis by Robin Blomdin, Stockholm University.
title: 16 – Entretien avec l’azmari Tadäsä : chant et bavardages
Creators: name: Wion, Anaïs
name: Bolay, Anne
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Chants et bavardages des clients dans l’arake bet.
Blomdin_PhDthesis_Paper_II_Suppl_data.pdf
Creators: name: Blomdin, Robin
Publisher: name: figshare
Year: 2016
Subjects: subject: 40601 Geomorphology and Regolith and Landscape Evolution
subject: FOS: Earth and related environmental sciences
subject: Physical Geography

description: This document describes the extended methodology and supplementary data of the manuscript "Paleoglaciation on opposite flanks of the Ikh-Turgen Mountains, Central Asia: Importance of style of moraine deposition for 10-Be surface exposure dating" by Blomdin et al., Paper II in the PhD thesis by Robin Blomdin, Stockholm University.
Effects of deep lithospheric processes and lateral crustal heterogeneity on the 3D evolution of foreland basins
Creators: name: Maiti, Giridas
name: Balázs, Attila
name: Eskens, Lucas
name: Gerya, Taras
name: Koptev, Alexander
name: Andrić-Tomašević, Nevena
Publisher: name: Copernicus
Year: 2023

description: Foreland basins develop in front of growing mountain belts due to the flexure of the downgoing plate in response to forces from slab pull and a topographic load. Many foreland basins worldwide show along-strike variable basin subsidence and architecture. Various factors such as lateral variations in slab pull, rheology and stress transfer, topographic loading of the adjacent mountain belt, presence of lateral crustal heterogeneity, slab breakoff, and its lateral tearing propagation have been suggested as drivers. However, the quantification of these factors is still lacking.In this contribution, we study the effects of slab break-off and tearing on the along-strike variations in foreland basin subsidence and deposition in a collisional setting. We also consider the heterogeneities of the lower plate continental margin by taking into account the presence of a microcontinent (i.e. Brianconnais high), being formed during a preceding extensional phase. To do so, we use 3D thermo-mechanical numerical models coupled with surface processes, such as sedimentation and erosion to investigate the effects of the following parameters on the foreland basin evolution: (1) convergence velocity, (2) age of the subducting oceanic lithosphere, (3) length of the subducting slab, (4) continental margin obliquity relative to the trench, and (5) presence of pre-existing rigid blocks in the downgoing plate.Our preliminary results show that younger age of the subducting oceanic slab (≤ 50 Ma) facilitate slab breakoff and basin uplift during continent-continent collision. On the other hand, the higher margin obliquity (≥ 15° ) causes a delay in the propagation of slab breakoff along the strike, i.e. lateral tearing. This process leads to diachronous basin subsidence and uplift along the strike. Finally, we discuss the implications of our results on the 3D evolution of the Northern Alpine Foreland Basin where slab breakoff and subsequent lateral tearing have been proposed as a probable controlling factor leading to the along-strike variations of the sedimentary basin architecture.
Ferramenta da Terapia Interpessoal (TIP): Técnica de Mapeamento de Recursos
Creators: name: Brandl, Edenilson
Publisher: name: Zenodo
Year: 2024
Subjects: Ferramenta da Terapia Interpessoal (TIP)
Técnica de Mapeamento de Recursos
Terapia Interpessoal (TIP)
Enciclopédia da Conscienciologia

description: Definologia: A Técnica de Mapeamento de Recursos é uma ferramenta da Terapia Interpessoal (TIP) utilizada para identificar e explorar os recursos pessoais e sociais disponíveis para o indivíduo em seu ambiente interpessoal.
Ferramenta da Terapia Psicodinâmica: Uso de Técnicas de Visualização Criativa
Creators: name: Brandl, Edenilson
Publisher: name: Zenodo
Year: 2024
Subjects: Ferramenta da Terapia Psicodinâmica
Terapia Psicodinâmica
Uso de Técnicas de Visualização Criativa
Enciclopédia da Conscienciologia

description: Definologia: A utilização de técnicas de visualização criativa é uma ferramenta da Terapia Psicodinâmica empregada no contexto terapêutico para acessar e explorar conteúdos inconscientes, promover insights e transformações pessoais.
Establishing an algorithm and technical system for non-invasive prediction of pregnancy diseases based on multi omics data
Creators: name: 李佳(Jia Li)
Publisher: name: CNGB
Year: 2024
Subjects: Proteome
Metabolome
Other
Plasma

description: Preeclampsia (PE) is an idiopathic disease of multiple system dysfunction in pregnancy with high blood pressure and proteinuria as the main symptoms after 20 weeks of pregnancy. Its incidence rate accounts for 5-8% of pregnant women. It can lead to severe perinatal diseases such as eclampsia and HELLP syndrome in the mother, and complications such as intrauterine distress, growth restriction and stillbirth in the fetus. It is an important cause of maternal and perinatal death. In recent years, studies have shown that differentially expressed genes in the promoter region (1000bp upstream and downstream of the transcription start site) of cfDNA genome sequencing, proteomics, and metabolomics can be used to predict the occurrence of preeclampsia with high accuracy. Based on previous research, this project intends to use cfDNA whole genome sequencing data, proteomics, metabolomics data and laboratory data to establish an algorithm and technical system for predicting preeclampsia, and complete the accuracy evaluation of this technical system.
The Impact of Time-Restricted Eating on Non-Alcoholic Fatty Liver Disease
Creators: name: 李志明(Lizhiming)
Publisher: name: CNGB
Year: 2024
Subjects: Raw sequence reads
Environment
Environmental

description: This was a randomized, parallel-arm, open-label trial among patients with NAFLD. For eight weeks, one arm received an 8-hour early time-restricted eating intervention (8h-eTRE group), and another arm received an 8-hour late time-restricted eating intervention (8h-lTRE group). During the intervention period, participants were instructed to keep to a regular diet and intake all meals within 8 hours each day. For the eTRE group, subjects were asked to consume all food from 8:00 a.m. to 16:00 p.m. This schedule allowed participants to choose a habitual meal time with the first meal scheduled for roughly 8:00 am, and with the remaining space for the first and last meal restricted in 8 hours. For instance, if the first meal begins at 7:00 am, and the last meal should be finished before 15:00 pm. Participants in the lTRE group will be instructed to consume all food between 12:00 pm and 20:00 pm. Similar to the eTRE, individuals could choose a usual time at around 12:00 for the first time, and with the eating window kept in 8 hours. For example, those who eat their first meal at 13:00 pm should conclude their last meal before 21:00 pm. There was no restriction on the type or quantity of meals throughout the 8-hour eating period for the eTRE and lTRE groups. Whereas for fasting periods, participants are not allowed to eat anything but are encouraged to drink water. Besides, all participants were instructed to maintain constant physical activity and sleep patterns, as well as not to change their dietary patterns and food choices except for meal timing.
title: 17 – Entretien avec l’azmari Tadäsä : chant et bavardages
Creators: name: Wion, Anaïs
name: Bolay, Anne
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Chants et bavardages des clients dans l’arake bet.
Modeling DNA methylation by analyzing the individual configurations of single molecules
Creators: name: Affinito, Ornella
name: Scala, Giovanni
name: Palumbo, Domenico
name: Florio, Ermanno
name: Monticelli, Antonella
name: Miele, Gennaro
name: Avvedimento, Vittorio Enrico
name: Usiello, Alessandro
name: Chiariotti, Lorenzo
name: Cocozza, Sergio
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified

description: DNA methylation is often analyzed by reporting the average methylation degree of each cytosine. In this study, we used a single molecule methylation analysis in order to look at the methylation conformation of individual molecules. Using D-aspartate oxidase as a model gene, we performed an in-depth methylation analysis through the developmental stages of 3 different mouse tissues (brain, lung, and gut), where this gene undergoes opposite methylation destiny. This approach allowed us to track both methylation and demethylation processes at high resolution. The complexity of these dynamics was markedly simplified by introducing the concept of methylation classes (MCs), defined as the number of methylated cytosines per molecule, irrespective of their position. The MC concept smooths the stochasticity of the system, allowing a more deterministic description. In this framework, we also propose a mathematical model based on the Markov chain. This model aims to identify the transition probability of a molecule from one MC to another during methylation and demethylation processes. The results of our model suggest that: 1) both processes are ruled by a dominant class of phenomena, namely, the gain or loss of one methyl group at a time; and 2) the probability of a single CpG site becoming methylated or demethylated depends on the methylation status of the whole molecule at that time.
Modelling DNA methylation by analyzing the individual configurations of single molecules
Creators: name: Affinito, Ornella
name: Scala, Giovanni
name: Palumbo, Domenico
name: Florio, Ermanno
name: Monticelli, Antonella
name: Miele, Gennaro
name: Avvedimento, Vittorio Enrico
name: Usiello, Alessandro
name: Chiariotti, Lorenzo
name: Cocozza, Sergio
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified

description: DNA methylation is often analyzed by reporting the average methylation degree of each cytosine. In this study, we used a single molecule methylation analysis in order to look at the methylation conformation of individual molecules. Using D-aspartate oxidase as a model gene, we performed an in-depth methylation analysis through the developmental stages of three different mouse tissues (brain, lung, and gut), where this gene undergoes opposite methylation destiny. This approach allowed us to track both methylation and demethylation processes at high resolution. The complexity of these dynamics was markedly simplified by introducing the concept of methylation classes (MCs), defined as the number of methylated cytosines per molecule, irrespective of their position. The MC concept smooths the stochasticity of the system, allowing a more deterministic description. In this framework, we also propose a mathematical model based on the Markov chain. This model aims to identify the transition probability of a molecule from one MC to another during methylation and demethylation processes. The results of our model suggest that: 1) both processes are ruled by a dominant class of phenomena, namely, the gain or loss of one methyl group at a time; and 2) the probability of a single CpG site becoming methylated or demethylated depends on the methylation status of the whole molecule at that time.
Using Version Control to Support High-Quality Phenotype Definitions
Creators: name: Chapman, Martin
name: Rasmussen, Luke
name: Pacheco, Jennifer
name: Curcin, Vasa
Publisher: name: Zenodo
Year: 2024

description: To increase the sophistication of EHR-based phenotype libraries we must look to existing tools from the software community. Version control systems can support the features needed in a modern library, including the presentation of definition relationships. We demonstrate this by refactoring an existing library, Phenoflow, to have a GitHub backend. Techniques such as repository branching are identified as key in supporting a next-generation library, and are an important part of delivering a `GitHub for phenotypes'.
Novel self-condensation of ammonium dithiocarbamates leading to symmetrical substituted thioureas
Creators: name: Şevket Hakan Üngören
name: Sırça, Fatih
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: For the first time, the formation of symmetrical substituted thiourea analogues generated by the self-condensation of trialkylammoniumdithiocarbamates is reported. The reactions occurred under mild conditions. The method allows the use of amines possessing a weak nucleophilic feature in good yields. The highlight of the study is a novel self-condensation mechanism based on dithiocarbamates as a basic compound in organic chemistry.
Nanoparticles of alkylglyceryl dextran and poly(ethyl cyanoacrylate) for applications in drug delivery: Preparation and characterization
Creators: name: Ibegbu, Daniel M.
name: Asme Boussahel
name: Cragg, Simon M.
name: Tsibouklis, John
name: Barbu, Eugen
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Toward the development of drug carriers that are capable of crossing biological membranes, controlled emulsion polymerization has been utilized to produce nanoparticulate carriers from the combination of poly(alkyl cyanoacrylate) and alkylglyceryl dextran to a molecular structure designed to combine the nonimmunogenic and stabilizing properties of dextran with the demonstrated permeation enhancing ability of alkylglycerols. To this aim, a systematic series of alkylglyceryl dextrans have been synthesized and functionalized with ethyl or butyl cyanoacrylates to form stable polymeric nanocarriers (100–500 nm). Results of investigations into their capability to act as controlled-release devices and their cytotoxicity against bEnd3 cells are reported.
PCOS data.xlsx
Creators: name: Zafar, Saba
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 310599
subject: Genetics not elsewhere classified
classificationCode: 320699
subject: Medical biotechnology not elsewhere classified
classificationCode: 310207
subject: Statistical and quantitative genetics
classificationCode: 420499
subject: Midwifery not elsewhere classified

description: Polycystic ovary syndrome (PCOS) is a prevalent hormonal disorder affecting women in their reproductive age and is more common in South Asia with 52% of cases only in Pakistan. This study investigated the role of SNPs rs2479106 and rs10818854 in the DENN Domain Containing 1A (DENND1A) gene with demographic and clinical factors in developing PCOS. We also investigated the factors that impact the number of ovarian cysts in women having PCOS and examined the sizes of the cysts with the number of cysts. We enrolled 320 subjects including 160 cases and 160 controls. DNA was extracted from their blood samples and the Tetra-Arm PCR method was utilized to amplify target DNA in DENND1A. The chi-square test determined the association between genetic and non-genetic variables with PCOS. The Classification and Regression Trees (CRT) model and odd ratios were used to identify the potential genetic, demographic, and clinical factors that cause PCOS. The results demonstrated a strong association between education, marital status, irregular menstrual cycles, and SNP rs2479106 (A/G) with PCOS while 71.4% of women with alternative genotype AA and 74.5% with genotype GA for SNP rs10818854 had PCOS. The CRT model indicated that the risk of PCOS increased in women with DENND1A gene variants, menstrual irregularity, abnormal hormone levels, and BMI > 22.5. Moreover, Women between their peak reproductive age (from >22 years to ≤ 29.5) would have the risk of developing more cysts in their ovaries. Our findings reflected that PCOS is a multifactorial condition influenced by hormonal imbalances, lifestyle choices, and genetics. Women with investigated SNPs are advised to maintain a healthy lifestyle to overcome the chances of PCOS. These results may help medical practitioners in risk assessment, enabling early intervention and management of disease to maintain the health of women.
title: 18 – Entretien avec l’azmari Tadäsä : chant et bavardages
Creators: name: Wion, Anaïs
name: Bolay, Anne
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Chants et bavardages des clients dans l’arake bet.
Presentation - Citizen Science at the Univeristy Library 'SVETOZAR MARKOVIĆ', Belgrade
Creators: name: Dakić, Nataša
name: Trtovac, Aleksandra
Publisher: name: Zenodo
Year: 2023
Subjects: citizen science

description: A presentation given by CeOS_SE representatives from UNILIB during an online conference with librarians from the Goethe Institute in Southeast Europe, 13th of March 2023.