cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sachdev-Ye-Kitaev model: Non-self-averaging properties of the energy spectrum
Creators: name: Berkovits, Richard
Publisher: name: arXiv
Year: 2022
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The short time (large energy) behavior of the Sachdev-Ye-Kitaev model (SYK) is one of the main motivation to the growing interest garnered by this model. True chaotic behaviour sets in at the Thouless time, which can be extracted from the energy spectrum. In order to do so, it is necessary to unfold the spectrum, i.e., to filter out global tendencies. Using a simple ensemble average for unfolding results in a parametically low estimation of the Thouless energy. By examining the behavior of the spectrum as the distribution of the matrix elements is changed into a log-normal distribution it is shown that the sample to sample level spacing variance determines this estimation of the Thouless energy. Using the singular value decomposition method, SVD, which filters out these sample to sample fluctuations, the Thouless energy becomes parametrically much larger, essentially of order of the band width. It is shown that the SYK model in non-self-averaging even in the thermodynamic limit which must be taken into account in considering its short time properties.
description: 7 pages, 6 figures
Allele frequency calculation from Men's preferences for women's body odours are not associated with human leucocyte antigen.
Creators: name: Probst, Fabian
name: Fischbacher, Urs
name: Lobmaier, Janek S.
name: Wirthmüller, Urs
name: Knoch, Daria
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 60801 Animal Behaviour

description: Typed alleles and their frequencies
DOWNLOAD [PDF] {EPUB} Getting to Know ArcGIS Pro 3.2 by Michael Law, Amy Collins
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Publisher: name: Zenodo
Year: 2024

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Supplementary Figure 2 from In situ developmental responses of tropical sea urchin embryos to ocean acidification conditions at naturally elevated pCO2 vent sites
Creators: name: Lamare, Miles
name: Liddy, Michelle
name: Uthicke, Sven
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Environmental Science
subject: Ecology
subject: FOS: Biological sciences
subject: Developmental Biology

description: Sea temperature measurements at control and vent sites for Experiment 1, Dobu Island (A) and Experiment 2, Upu Upasina (B). Measurements are made using seaFET pH/temperature logger that was moored at 2 to 3 m depth.
The burden of selected digestive diseases in the United States
Creators: name: Shah, Shefali
name: Cronin, Kelly
name: Sandler, Robert S.
name: Donowitz, Mark
name: Avdic, Aida
name: Gemmen, Eric
name: Goodman, Clifford
name: Rubin, Robert
name: Everhart, James E.
name: Adams, Elizabeth
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: AbstractBackground & Aims: Gastrointestinal (GI) and liver diseases inflict a heavy economic burden. Although the burden is considerable, current and accessible information on the prevalence, morbidity, and cost is sparse. This study was undertaken to estimate the economic burden of GI and liver disease in the United States for use by policy makers, health care providers, and the public. Methods: Data were extracted from a number of publicly available and proprietary national databases to determine the prevalence, direct costs, and indirect costs for 17 selected GI and liver diseases. Indirect cost calculations were purposefully very conservative. These costs were compared with National Institutes of Health (NIH) research expenditures for selected GI and liver diseases. Results: The most prevalent diseases were non–food-borne gastroenteritis (135 million cases/year), food-borne illness (76 million), gastroesophageal reflux disease (GERD; 19 million), and irritable bowel syndrome (IBS; 15 million). The disease with the highest annual direct costs in the United States was GERD ($9.3 billion), followed by gallbladder disease ($5.8 billion), colorectal cancer ($4.8 billion), and peptic ulcer disease ($3.1 billion). The estimated direct costs for these 17 diseases in 1998 dollars were $36.0 billion, with estimated indirect costs of $22.8 billion. The estimated direct costs for all digestive diseases were $85.5 billion. Total NIH research expenditures were $676 million in 2000. Conclusions: GI and liver diseases exact heavy economic and social costs in the United States. Understanding the prevalence and costs of these diseases is important to help set priorities to reduce the burden of illness.GASTROENTEROLOGY 2002;122:1500-1511
Artenreiche Landwirtschaft auf Kirchengrund. Chancen gelebter Schöpfungsverantwortung. Eine Handreichung zur Umsetzung von Naturschutzmaßnahmen auf kircheneigenem Land
Creators: name: Schwarz, Benjamin U.
name: Rühs, Michael
name: Beil, Thomas
Publisher: name: Universität Regensburg
Year: 2018
Subjects: subject: Biodiversität, Landwirtschaft, Kirche, Kirchengrund, Kirchenland, Artenreiche Landwirtschaft, Schöpfungsverantwortung, Handreichung
subject: 230 Theologie, Christentum

description: Die Handreichung setzt sich mit den Potenzialen und konkreten Möglichkeiten von Naturschutzmaßnahmen auf kircheneigenem Land auseinander. In einer kurzen theologischen Zusammenschau wird zunächst der Biodiversitätsschutz als Aufgabe gelebter christlicher Schöpfungsverantwortung identifiziert. Im Anschluss daran werden mögliche Handlungsschritte für eine Umsetzung entsprechender Maßnahmen vorgestellt. Dabei werden sowohl die Fragen nach dem Zuständigkeitsbereich sowie nach Kooperations- und Finanzierungsmöglichkeiten geklärt als auch einzelne Maßnahmen zum Schutz von Artenvielfalt detailliert und praxisnah beschrieben. Am Ende der Handreichung lassen sich mehrere Beispiele für bereits bestehende und vorbildliche Realisierungen von Naturschutzmaßnahmen auf kircheneigenem Land finden. Darüber hinaus werden auf den letzten Seiten Ansprechpartner und unterstützende Instanzen genannt.
description: Gefördert aus Mitteln des Bundesministeriums für Ernährung und Landwirtschaft (BMEL) aufgrund eines Beschlusses des deutschen Bundestages. Die Projektträgerschaft erfolgte über die Bundesanstalt für Landwirtschaft und Ernährung (BLE).
(3033) Thomas Arthur Robinson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Limits of Entrainment of Circadian Neuronal Networks
Creators: name: Psarellis, Yorgos M.
name: Kavousanakis, Michail
name: Henson, Michael A.
name: Kevrekidis, Ioannis G.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Neurons and Cognition (q-bio.NC)
subject: Numerical Analysis (math.NA)
subject: Dynamical Systems (math.DS)
subject: Quantitative Methods (q-bio.QM)
subject: Machine Learning (stat.ML)
subject: FOS: Biological sciences
subject: FOS: Mathematics
subject: FOS: Computer and information sciences

description: Circadian rhythmicity lies at the center of various important physiological and behavioral processes in mammals, such as sleep, metabolism, homeostasis, mood changes and more. It has been shown that this rhythm arises from self-sustained biomolecular oscillations of a neuronal network located in the Suprachiasmatic Nucleus (SCN). Under normal circumstances, this network remains synchronized to the day-night cycle due to signaling from the retina. Misalignment of these neuronal oscillations with the external light signal can disrupt numerous physiological functions and take a long-lasting toll on health and well-being. In this work, we study a modern computational neuroscience model to determine the limits of circadian synchronization to external light signals of different frequency and duty cycle. We employ a matrix-free approach to locate periodic steady states of the high-dimensional model for various driving conditions. Our algorithmic pipeline enables numerical continuation and construction of bifurcation diagrams w.r.t. forcing parameters. We computationally explore the effect of heterogeneity in the circadian neuronal network, as well as the effect of corrective therapeutic interventions, such as that of the drug molecule Longdaysin. Lastly, we employ unsupervised learning to construct a data-driven embedding space for representing neuronal heterogeneity.
description: 14 pages, 15 figures
Odour Collection from Men's preferences for women's body odours are not associated with human leucocyte antigen.
Creators: name: Probst, Fabian
name: Fischbacher, Urs
name: Lobmaier, Janek S.
name: Wirthmüller, Urs
name: Knoch, Daria
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 60801 Animal Behaviour

description: Details on the odour collection
(3028) John E[dward] Wade
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Alterations of brain activity associated with resolution of emotional distress and pain in a case of severe irritable bowel syndrome
Creators: name: Smith, J. Keith
name: Ringel, Yehuda
name: Whitehead, William
name: Leserman, Jane
name: Lin, Weili
name: Drossman, Douglas A.
name: Vogt, Brent A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: : The association of psychosocial disturbances with more severe irritable bowel syndrome (IBS) is well recognized. However, there is no evidence as to how these associations might be mediated. Functional magnetic resonance imaging (fMRI) offers an opportunity to study whether activation of the cingulate cortex, an area involved with the affective and pain intensity coding might be linked to poorer clinical status with IBS. In this case report, we found an association between the severity of a patient's clinical symptoms and psychosocial state, with activation of the cingulate cortex. We also found that clinical and psychosocial improvement was associated with reduced cingulate activation. : Observational case report of a young woman observed for 16 years with a history of sexual abuse, psychosocial distress, and functional GI complaints. Psychosocial, clinical, and fMRI assessment was performed when the patient experienced severe symptoms and again 8 months later when clinically improved. : During severe illness, the patient had major psychosocial impairment, high life stress, a low visceral pain threshold, and activation of the midcingulate cortex (MCC), prefrontal area 6/44, and the somatosensory cortex, areas associated with pain intensity encoding. When clinically improved, there was resolution in activation of these 3 areas, and this was associated with psychosocial improvement and an increased threshold to rectal distention. : Activation of the MCC and related areas involved with visceral pain encoding are associated with poor clinical status in patients with severe IBS and psychosocial distress and appear to be responsive to clinical improvement.GASTROENTEROLOGY 2003;124:754-761
The silicate absorption profile in the ISM towards the heavily obscured nucleus of NGC 4418
Creators: name: Roche, P. F.
name: Alonso-Herrero, A.
name: Gonzalez-Martin, O.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The 9.7-micron silicate absorption profile in the interstellar medium provides important information on the physical and chemical composition of interstellar dust grains. Measurements in the Milky Way have shown that the profile in the diffuse interstellar medium is very similar to the amorphous silicate profiles found in circumstellar dust shells around late M stars, and narrower than the silicate profile in denser star-forming regions. Here, we investigate the silicate absorption profile towards the very heavily obscured nucleus of NGC 4418, the galaxy with the deepest known silicate absorption feature, and compare it to the profiles seen in the Milky Way. Comparison between the 8-13 micron spectrum obtained with TReCS on Gemini and the larger aperture spectrum obtained from the Spitzer archive indicates that the former isolates the nuclear emission, while Spitzer detects low surface brightness circumnuclear diffuse emission in addition. The silicate absorption profile towards the nucleus is very similar to that in the diffuse ISM in the Milky Way with no evidence of spectral structure from crystalline silicates or silicon carbide grains.
description: 7 Pages, 3 figures. MNRAS in press
Celestial chiral algebras, colour-kinematics duality and integrability
Creators: name: Monteiro, Ricardo
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study celestial chiral algebras appearing in celestial holography, using the light-cone gauge formulation of self-dual Yang-Mills theory and self-dual gravity, and explore also a deformation of the latter. The recently discussed $w_{1+\infty}$ algebra in self-dual gravity arises from the soft expansion of an area-preserving diffeomorphism algebra, which plays the role of the kinematic algebra in the colour-kinematics duality and the double copy relation between the self-dual theories. The $W_{1+\infty}$ deformation of $w_{1+\infty}$ arises from a Moyal deformation of self-dual gravity. This theory is interpreted as a constrained chiral higher-spin gravity, where the field is a tower of higher-spin components fully constrained by the graviton component. In all these theories, the chiral structure of the operator-product expansion exhibits the colour-kinematics duality: the implicit `left algebra' is the self-dual kinematic algebra, while the `right algebra' provides the structure constants of the operator-product expansion, ensuring its associativity at tree level. In a scattering amplitudes version of the Ward conjecture, the left algebra ensures the classical integrability of this type of theories. In particular, it enforces the vanishing of the tree-level amplitudes via the double copy.
description: 23 pages, 1 figure. v2: minor changes, published version
Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury
Creators: name: Lemasters, John J.
name: Jaeschke, Hartmut
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: AbstractWarm and cold hepatic ischemia followed by reperfusion leads to necrotic cell death (oncosis), which often occurs within minutes of reperfusion. Recent studies also suggest a large component of apoptosis after ischemia/reperfusion. Here, we review the mechanisms underlying adenosine triphosphate depletion—dependent oncotic necrosis and caspase-dependent apoptosis, with emphasis on shared features and pathways. Although apoptosis causes internucleosomal DNA degradation that can be detected by terminal deoxynucleotidyl transferase—mediated deoxyuridine triphosphate nick-end labeling and related assays, DNA degradation also occurs after oncotic necrosis and leads to pervasive terminal deoxynucleotidyl transferase—mediated deoxyuridine triphosphate nick-end labeling staining far in excess of that for apoptosis. Similarly, although apoptosis can occur in a physiological setting without inflammation, in pathophysiological settings apoptosis frequently induces inflammation because of the onset of secondary necrosis and stimulation of cytokine and chemokine formation. In liver, the mitochondrial permeability transition represents a shared pathway that leads to both oncotic necrosis and apoptosis. When the mitochondrial permeability transition causes severe adenosine triphosphate depletion, plasma membrane failure and necrosis ensue. If adenosine triphosphate is preserved, at least in part, cytochrome c release after the mitochondrial permeability transition activates caspase-dependent apoptosis. Mitochondrial permeability transition-dependent cell death illustrates the concept of necrapoptosis, whereby common pathways lead to both necrosis and apoptosis. In conclusion, oncotic necrosis and apoptosis can share features and mechanisms, which sometimes makes discrimination between the 2 forms of cell death difficult. However, elucidation of critical cell death pathways under clinically relevant conditions will show potentially important therapeutic intervention strategies in hepatic ischemia/reperfusion injury.
Bid activates multiple mitochondrial apoptotic mechanisms in primary hepatocytes after death receptor engagement
Creators: name: Zhao, Yongge
name: Lemasters, John J.
name: Qian, Ting
name: Yin, Xiao Ming
name: Watkins, Simon
name: Ding, Wen Xing
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: : Activation of Fas or tumor necrosis factor receptor 1 (TNF-R1) on hepatocytes leads to apoptosis, which requires mitochondria activation. The pro-death Bcl-2 family protein, Bid, mediates this pathway by inducing mitochondrial releases of cytochrome c and other apoptotic factors. How Bid activates mitochondria has been studied in vitro with isolated mitochondria. We intended to study the mechanisms in intact hepatocytes so that findings could be made in a proper cellular context and would be more physiologically relevant. : Hepatocytes were isolated from wild-type and bid-deficient mice and treated with anti-Fas or TNF-α. Mechanisms of mitochondria activation were dissected with genetic, biochemical, and morphologic approaches. :bid-deficient hepatocytes were much more resistant to apoptosis. Bid was required for permeability transition and mitochondria depolarization in addition to the previously defined release of cytochrome c. Permeability transition inhibitors cyclosporin A and aristolochic acid could inhibit mitochondria activation effectively, but not as much as the deletion of the bid gene, and they could not inhibit Bak oligomerization. In addition, mitochondria depolarization also could be induced by caspases, whose activation was mainly dependent on Bid. : Bid may activate mitochondria by 2 mechanisms, one is related to permeability transition and the other is related to Bak oligomerization. Bid can further affect mitochondria potentials by indirectly regulating caspase activity. This in vivo study provides novel findings not previously disclosed by in vitro studies, and indicates the importance of several mechanisms in contributing Bid-mediated mitochondria dysfunction that could be potential cellular targets of intervention.
Vacuum stability of the type II seesaw leptogenesis from inflation
Creators: name: Han, Chengcheng
name: Huang, Sihui
name: Lei, Zhanhong
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Recently it has been found that introducing a triplet Higgs to the standard model could provide a feasible leptogenesis to generate the baryon asymmetry of our universe, providing that the inflation is driven by the mixing state of the triplet Higgs and SM Higgs. In this work, we survey the viable parameter space satisfying the vacuum stability and perturbativity in this model. We find that the introduction of the triplet Higgs would also ameliorate the problem of the Higgs vacuum instability. We present two representative parameter regions where the origin of neutrino masses, baryon asymmetry of the universe as well as inflation can be explained while keeping consistent with the condition of vacuum stability and perturbativity.
A systematic review and conceptual framework of key performance indicators for urban public safety smartness for cities in Andalusia, Spain
Creators: name: Amores, Francisco
name: Del-Real, Cristina
name: Fernández, Antonio
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Science and Technology Policy
subject: Science and Technology Studies
subject: Sociology
subject: FOS: Sociology
subject: Urban Studies and Planning
subject: Emergency and Disaster Management
subject: Social and Behavioral Sciences
subject: Criminology
subject: FOS: Law
subject: Place and Environment
subject: Urban Studies
subject: Public Affairs, Public Policy and Public Administration
subject: key performance indicators
subject: public safety
subject: security technology
subject: smart city
subject: smart public safety
subject: smart security
subject: systematic review

description: The present project aims to summarize the KPIs used to assess public safety smartness and critically review the applicability of current ones to the Andalucian context. Specifically, the project describes a systematic review to summarize the indicators that have been designed and used to measure urban public safety smartness, within which smart city dimensions have the KPI been located, and how are the KPI defined and measured.
Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat
Creators: name: Nishio, Toshihiro
name: Stefanovic, Branko
name: Yamaoka, Yoshio
name: Iimuro, Yuji
name: Choi, Sung Kyu
name: Morimoto, Taisuke
name: Nitta, Takashi
name: Brenner, David A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: BACKGROUND & AIMS: During hepatic fibrogenesis, the hepatic extracellular matrix changes to fibrillar collagens types I and III, and cirrhosis is believed to produce an irreversible scar. In this study, we investigated whether gene delivery of human matrix metalloproteinase-1, which degrades collagens types I and type III, would attenuate established hepatic fibrosis in the rat, induced by either thioacetamide or bile duct ligation.

METHODS: Hepatic fibrosis induced by thioacetamide for 7 weeks was persistent for at least 2 months, even after discontinuation of the treatment. The rats were infected once with a recombinant adenovirus, Ad5MMP-1, into which human pro-human matrix metalloproteinase-1 complementary DNA was packaged, or with a control adenovirus, Ad5LacZ.

RESULTS: In Ad5MMP-1-infected, but not in Ad5LacZ-infected, rats, the fibrosis was dramatically attenuated at 2 weeks after the infection. It is interesting to note that the number of activated hepatic stellate cells was also decreased in Ad5MMP-1-infected rats. Moreover, disorganization of the hepatic trabecula, heterogeneity in the size of hepatocytes, and increased dried liver weight were observed only in Ad5MMP-1-treated rats, suggesting that human matrix metalloproteinase-1 stimulated hepatocyte proliferation, which was confirmed by bromodeoxyuridine staining. After 4 weeks, the proliferative effect of human matrix metalloproteinase-1 almost disappeared, but the hepatic fibrosis remained attenuated, whereas the fibrosis in Ad5LacZ-treated rats persisted. Furthermore, the administration of Ad5MMP-1, but not Ad5LacZ, decreased type I collagen and generated a small collagen fragment in hepatic fibrosis induced by bile duct ligation.

CONCLUSIONS: Our findings show that transient human matrix metalloproteinase-1 overexpression in the liver effectively attenuates established fibrosis and induces hepatocyte proliferation.
Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms
Creators: name: Rabkin, Charles S.
name: Goedert, James
name: Fraumeni Jr., Joseph F.
name: Stanford, Janet L.
name: Blot, William J.
name: Gammon, Marilie D.
name: Risch, Harvey A.
name: Mayne, Susan T.
name: Wong-Ho, Chow
name: Schoenberg, Janet B.
name: Vaughan, Thomas L.
name: El-Omar, Emad M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: AbstractBackground & Aims:Genetic variations in proinflammatory and anti-inflammatory cytokine genes influence individual response to carcinogenic exposures. Polymorphisms in interleukin (IL)-1β and its endogenous receptor antagonist are associated with risk of Helicobacter pylori-related gastric cancer. The aim of this study was to evaluate the role of proinflammatory cytokine gene polymorphisms in gastric and esophageal cancers defined by anatomic subsite.Methods:We assessed polymorphisms of the IL-1 gene cluster and 4 other cytokine genes in a population-based case-control study of upper gastrointestinal cancers, including gastric cardia (n = 126) and noncardia adenocarcinoma (n = 188), esophageal squamous cell carcinoma (n = 53), and adenocarcinoma (n = 108), and frequency-matched controls (n = 212). ORs for the different cancers were computed from logistic regression models adjusted for potential confounding factors.Results:Proinflammatory genotypes of tumor necrosis factor α and IL-10 were each associated with more than doubling of the risk of noncardia gastric cancer. Carriage of multiple proinflammatory polymorphisms of IL-1Bo IL-1 receptor antagonist, tumor necrosis factor A, and IL-10 conferred greater risk, with ORs (and 95% confidence intervals) of 2.8 (1.6–5.1) for one, 5.4 (2.7–10.6) for 2, and 27.3 (7.4–99.8) for 3 or 4 high-risk genotypes. In contrast, these polymorphisms were not consistently related to the risks of esophageal or gastric cardia cancers. Polymorphisms in IL-4 and IL-6 were not associated with any of the cancers studied.Conclusions:A proinflammatory cytokine genetic profile increases the risk of noncardia gastric adenocarcinoma but not other upper gastrointestinal cancers, possibly by inducing a hypochlorhydric and atrophic response to gastric H. pylori infection.
Mitochondrial permeability transition in the switch from necrotic to apoptotic cell death in ischemic rat hepatocytes
Creators: name: Qian, Ting
name: Lemasters, John J.
name: Kim, Jae Sung
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: AbstractBackground & Aims: Ischemia/reperfusion can initiate both necrotic and apoptotic death of hepatocytes. Previous work showed that onset of the mitochondrial permeability transition (MPT) can initiate necrotic cell death after reperfusion, but the MPT is also implicated in apoptosis. Here, we investigated factors regulating how cell death switches from necrosis to apoptosis after ischemia/reperfusion injury. Methods: Overnight cultured rat hepatocytes were incubated in anoxia at pH 6.2 for 4 hours and reoxygenated at pH 7.4 to simulate ischemia/reperfusion. Some cells were incubated with fructose plus glycine just before and then continuously after reperfusion. Development of apoptosis was evaluated by examining chromatin condensation, nuclear DNA fragmentation, and caspase 3 activity. Results: Reperfusion with the glycolytic substrate fructose plus the cytoprotective amino acid glycine prevented necrotic cell killing. Instead, apoptosis developed within 12 hours as shown by nuclear chromatin changes, TUNEL staining, and caspase 3 activation. This apoptotic cell killing was prevented by cyclosporin A, an MPT blocker, and by pancaspase and caspase 3 inhibition, but not by caspase 8 inhibition. Cyclosporin A also blocked caspase-3 activation. Reperfusion with glycine alone prevented necrotic cell death but did not induce apoptosis and only poorly promoted recovery of ATP, whereas fructose alone during reperfusion promoted both ATP recovery and apoptosis. Conclusions: Glycolytic ATP generation after reperfusion prevents necrotic killing of hepatocytes after simulated ischemia/reperfusion despite onset of the MPT. Instead, the MPT promotes caspase-and ATP-dependent apoptosis. Thus, the MPT is a common mechanism responsible for both necrosis and apoptosis after ischemia/reperfusion.
Bulk renormalization and the AdS/CFT correspondence
Creators: name: Bañados, Máximo
name: Bianchi, Ernesto
name: Muñoz, Iván
name: Skenderis, Kostas
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We develop a systematic renormalization procedure for QFT in anti-de Sitter spacetime. UV infinities are regulated using a geodesic point-splitting method, which respects AdS isometries, while IR infinities are regulated by cutting off the radial direction (as in holographic renormalization). The renormalized theory is defined by introducing $Z$ factors for all parameters in the Lagrangian and the boundary conditions of bulk fields (sources of dual operators), and a boundary counterterm action, $S_{\rm ct}$, such that the limit of removing the UV and IR regulators exists. The results are in general scheme dependent (mirroring the analogous result in flat space) and require renormalization conditions. These may be provided by the dual CFT (or by string theory in AdS). Our analysis amounts also to a first principles derivation of the Feynman rules regarding Witten diagrams. The presence and treatment of IR divergences is essential for correctly accounting for anomalous dimensions of dual operators. We apply the method to scalar $Φ^4$ theory and obtain the renormalized 2-point function of the dual operator to 2-loops, and the renormalized 4-point function to 1-loop order, for operators of any dimension $Δ$ and bulk spacetime dimension up to $d+1=7$.
description: 7 pages, 1 figure; v2: Comments and references added. Published version
Pharmacogenetics and clinical gastroenterology
Creators: name: Watkins, Paul B.
name: Givens, Raymond C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: AbstractMany drugs exhibit variable efficacy and toxicity. Pharmacogenetics explores the genetic underpinnings of variable drug response. Pharmacogenetic testing is beginning to enter the clinic and will have a significant impact on the practice of clinical gastroenterology. Thiopurine S-methyltransferase screening, which will likely become routine for thiopurine recipients, illustrates the promise and limitations of pharmacogenetics. Testing for variation in other drug metabolism pathways may also become important. Pharmacogenetics will complement but not replace traditional methods for choosing drugs and for selecting dosing regimens for narrow-therapeutic-index drugs.
(3030) Carrie Wade
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Tacrolimus for the treatment of fistulas in patients with crohn’s disease: a randomized, placebo-controlled trial
Creators: name: Hanauer, Stephen B.
name: Johnson, Therese
name: Sandborn, William J.
name: Martin, Christopher
name: Present, Daniel H.
name: Mayer, Lloyd
name: Greenberg, Eugene
name: Galanko, Joseph
name: Isaacs, Kim L.
name: Sandler, Robert S.
name: Wolf, Douglas C.
name: Feagan, Brian G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: AbstractBackground & Aims:This study determined the effectiveness of tacrolimus for the treatment of Crohn's disease fistulas.Methods:The study was a randomized, double-blind, placebo-controlled, multicenter clinical trial. Forty-eight patients with Crohn's disease and draining perianal or enterocutaneous fistulas were randomized to treatment with oral tacrolimus 0.2 mg · kg−1 · day−1 or placebo for 10 weeks. The primary outcome measure was fistula improvement as defined by closure of ≥50% of particular fistulas that were draining at baseline and maintenance of that closure for at least 4 weeks. A secondary outcome measure was fistula remission as defined by closure of all fistulas and maintenance of that closure for at least 4 weeks.Results:Forty-three percent of tacrolimus-treated patients had fistula improvement compared with 8% of placebo-treated patients (P = 0.004). Ten percent of tacrolimus-treated patients had fistula remission compared with 8% of placebo-treated patients (P = 0.86). Adverse events significantly associated with tacrolimus, including headache, increased serum creatinine level, insomnia, leg cramps, paresthesias, and tremor, were managed with dose reduction.Conclusions:Oral tacrolimus 0.2 mg · kg−1 · day−1 is effective for fistula improvement, but not fistula remission, in patients with perianal Crohn's disease. Adverse events associated with tacrolimus can be managed by dose reduction. Lower doses of tacrolimus should be evaluated.
Additional figure and table from Men's preferences for women's body odours are not associated with human leucocyte antigen.
Creators: name: Probst, Fabian
name: Fischbacher, Urs
name: Lobmaier, Janek S.
name: Wirthmüller, Urs
name: Knoch, Daria
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 60801 Animal Behaviour

description: Relation between attractiveness, pleasantness and intensity ratings and the rareness of HLA alleles / Results of the pleasantness ratings
Lithurgus Berthold 1827
Creators: name: Gonzalez, Victor H.
name: Engel, Michael S.
name: Griswold, Terry L.
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Megachilidae
Lithurgus

description: Genus Lithurgus Berthold
 Lithurge Latreille, 1825: 463 [French vernacular name]. Type species: Andrena cornuta Fabricius, 1787, monobasic.
 Lithurgus Berthold, 1827: 467, nomen emendatum pro Lithurge Latreille, 1825. Type species: Andrena cornuta Fabricius, 1787, autobasic [Michener (1997) listed this as a subsequent designation].
 Liturgus Ashmead, 1899: 77, lapsus calami pro Lithurgus Berthold, 1827.
 COMMENTS: We have removed Lithurgopsis from Lithurgus, thereby not recognizing subgenera within this genus (as was done by Moure & Melo, 2007), and consider the two to be generically distinct (refer also to the key to genera: vide infra). This action accords with past and current studies indicating that the former composition of Lithurgus in a broader sense was paraphyletic (Engel, 2001; Michener, 2007). As it is, the restriction of Lithurgus as such may not resolve all issues pertaining to its paraphyly. However, we believe that this is a necessary first step toward eventually achieving a stable and useful classification of Lithurgini.
description: Published as part of Gonzalez, Victor H., Engel, Michael S. & Griswold, Terry L., 2013, The lithurgine bees of Australia (Hymenoptera: Megachilidae), with a note on Megachile rotundipennis, pp. 1-19 in Journal of Melittology 2013 (11) on page 9, DOI: 10.17161/jom.v0i11.4520, http://zenodo.org/record/13737296
Allele frequency calculation from Men's preferences for women's body odours are not associated with human leucocyte antigen
Creators: name: Probst, Fabian
name: Fischbacher, Urs
name: Lobmaier, Janek S.
name: Wirthmüller, Urs
name: Knoch, Daria
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 60801 Animal Behaviour

description: Typed alleles and their frequencies
Rapid Blue- and Red-shifted Excursions in H$α$ line profiles synthesized from realistic 3D MHD simulations
Creators: name: Danilovic, S.
name: Bjørgen, J. P.
name: Leenaarts, J.
name: Rempel, M.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Rapid blue- and red-shifted events (RBEs/RREs) may have an important role in mass-loading and heating the solar corona, but their nature and origin are still debatable. We aim to model these features to learn more about their properties, formation and origin. A realistic three-dimensional (3D) magneto-hydrodynamic (MHD) model of a solar plage region is created. Synthetic H$α$ spectra are generated and the spectral signatures of these features are identified. The magnetic field lines associated with these events are traced and the underlying dynamic is studied. The model reproduces well many properties of RBEs and RREs, such as spatial distribution, lateral movement, length and lifetimes. Synthetic H$α$ line profiles, similarly to observed ones, show strong blue- or red-shift and asymmetries. These line profiles are caused by the vertical component of velocity with magnitudes larger than $30-40$ km/s that appear mostly in the height range of $2-4$ Mm. By tracing magnetic field lines, we show that the vertical velocity that causes the appearance of RBE/RREs to appear is always associated with the component of velocity perpendicular to the magnetic field line. The study confirms the hypothesis that RBEs and RREs are signs of Alfv{é}nic waves with, in some cases, a significant contribution from slow magneto-acoustic mode.
description: submitted to A&A, movies in https://dubshen.astro.su.se/~sdani/rbes/
Diagonal and transition magnetic moments of negative parity heavy baryons in QCD sum rules
Creators: name: Aliev, T. M.
name: Azizi, K.
name: Barakat, T.
name: Savcı, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Diagonal and transition magnetic moments of the negative parity, spin-1/2 heavy baryons are studied in framework of the light cone QCD sum rules. By constructing the sum rules for different Lorentz structures, the unwanted contributions coming from negative (positive) to positive (negative) parity transitions are removed. It is obtained that the magnetic moments of all baryons, except $Λ_b^0$, $Σ_c^+$ and $Ξ_c^{\prime +}$, are quite large. It is also found that the transition magnetic moments between neutral negative parity heavy $Ξ_Q^{\prime 0}$ and $Ξ_Q^0$ baryons are very small. Magnetic moments of the $Σ_Q \to Λ_Q$ and $ Ξ_Q^{\prime \pm} \to Ξ_Q^\pm$ transitions are quite large and can be measured in further experiments.
description: 31 pages, 4 figures, LaTeX formatted. arXiv admin note: substantial text overlap with arXiv:1504.00172, arXiv:1504.08187
Odour Collection from Men's preferences for women's body odours are not associated with human leucocyte antigen
Creators: name: Probst, Fabian
name: Fischbacher, Urs
name: Lobmaier, Janek S.
name: Wirthmüller, Urs
name: Knoch, Daria
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 60801 Animal Behaviour

description: Details on the odour collection
SN 2009ib: A Type II-P Supernova with an Unusually Long Plateau
Creators: name: Takats, K.
name: Pignata, G.
name: Pumo, M. L.
name: Paillas, E.
name: Zampieri, L.
name: Elias-Rosa, N.
name: Benetti, S.
name: Bufano, F.
name: Cappellaro, E.
name: Ergon, M.
name: Fraser, M.
name: Hamuy, M.
name: Inserra, C.
name: Kankare, E.
name: Smartt, S. J.
name: Stritzinger, M. D.
name: Van Dyk, S. D.
name: Haislip, J. B.
name: LaCluyze, A. P.
name: Moore, J. P.
name: Reichart, D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present optical and near-infrared photometry and spectroscopy of SN 2009ib, a Type II-P supernova in NGC 1559. This object has moderate brightness, similar to those of the intermediate-luminosity SNe 2008in and 2009N. Its plateau phase is unusually long, lasting for about 130 days after explosion. The spectra are similar to those of the subluminous SN 2002gd, with moderate expansion velocities. We estimate the $^{56}$Ni mass produced as $0.046 \pm 0.015\,{\rm M}_{\sun}$. We determine the distance to SN 2009ib using both the expanding photosphere method (EPM) and the standard candle method. We also apply EPM to SN 1986L, a type II-P SN that exploded in the same galaxy. Combining the results of different methods, we conclude the distance to NGC 1559 as $D=19.8 \pm 3.0$ Mpc. We examine archival, pre-explosion images of the field taken with the Hubble Space Telescope, and find a faint source at the position of the SN, which has a yellow colour ($(V-I)_0 = 0.85$ mag). Assuming it is a single star, we estimate its initial mass as $M_{\rm ZAMS}=20\,{\rm M}_{\sun}$. We also examine the possibility, that instead of the yellow source the progenitor of SN 2009ib is a red supergiant star too faint to be detected. In this case we estimate the upper limit for the initial zero-age main sequence mass of the progenitor to be $\sim 14-17\,{\rm M}_{\sun}$. In addition, we infer the physical properties of the progenitor at the explosion via hydrodynamical modelling of the observables, and estimate the total energy as $\sim 0.55 \times 10^{51}$~erg, the pre-explosion radius as $\sim 400\,{\rm R}_{\sun}$, and the ejected envelope mass as $\sim 15\,{\rm M}_{\sun}$, which implies that the mass of the progenitor before explosion was $\sim 16.5-17\,{\rm M}_{\sun}$.
description: 18 pages plus 7 page appendix; accepted version (MNRAS), v3: a reference and typos corrected
DISFRUTAR (VOL. 2)
Creators: name: Weber
Publisher: name: Zenodo
Year: 2024

description: DISFRUTAR (VOL. 2) (edición en inglés) de ORIOL CASTRO, EDUARD XATRUCH, MATEU CASAÑAS

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Ficha técnica

DISFRUTAR (VOL. 2) (edición en inglés)

ORIOL CASTRO, EDUARD XATRUCH, MATEU CASAÑAS

Idioma: INGLÉS

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788412570717

Editorial: ABALON BOOKS

Año de edición: 2023

 

 

 

 

 

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Overview

After the publication of the restaurant?s multi-award-winning first book Disfrutar Vol. 1, this second volume by Oriol Castro, Eduard Xatruch and Mateu Casañas offers the continuation of an ambitious publishing project dedicated to their acclaimed Barcelona restaurant, this time tracing their subsequent stage, 2018-2020, accompanied by a personal account of those years filled with undeniable challenges. Disfrutar Vol. 2 showcases the evolution of a restaurant impregnated with creativity in every aspect that continues to lead the way at the international culinary cutting edge, creating a style and, for many, a school of its own. This new volume is also dedicated to a creative Catalogue that is truly impressive, both for the sheer number of new dishes ? of which 96 already highly successful ones have been chosen for this volume ? and for the development of genuinely innovative techniques and concepts, now also available in audiovisual format through links provided by QR codes. A culinary masterpiece by a restaurant that has steadily grown and never ceased to amaze with the track record it has earned for itself in such a short lifetime.
(3031) Harry Dickinson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.