cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Religione e guarigione: libertà religiosa e principio di autodeterminazione in materia di salute mentale (salus aegroti suprema lex o voluntas aegroti suprema lex)
Creators: name: Pettinato, Cristiana Maria
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2019

description: SOMMARIO: 1. Linee di lettura - 2. La guarigione forzata: i fatti di Vilnius - 3. Il percorso giudiziario che conduce alla decisione di Strasburgo - 4. La dissenting opinion: brevi appunti sul metodo -5. Il sofferto cammino della libertà religiosa tra fede, stregoneria e follia - 6. La forza terapeutica della libertà religiosa: “capacità-libertà” di credere e diritto di guarire - 7. La funzione politica della religione in terra lituana: semi di neo-confessionismo - 8. La sfida dell’inclusione dell’altro da sé: scelte etero-spirituali e prudentia iuris. Religion and healing: religious freedom and the principle of self-determination in matters of mental health (Salus aegroti suprema lex o voluntas aegroti suprema ABSTRACT: The case before the Court of Strasbourg, projects us into the most sacred and private dimension of the life of the human being: that of religious options. In the present case, a young woman with behavioral disorders, manifested even before joining the group close to the Movement founded by the Indian Master Osho, following undergoes a series of medical treatments obligatory that force her to the suspension of the religious practices to which she usually devotes for her own psychophysical well-being. But according to the opinion of the doctors these practices compromised the applicant's mental health status, representing a serious and ascertained danger. The doctor becoming the promoter of his patient's health, ends up interfering in the personal sphere of the girl's religious sentiment, trying to modify the choices deemed to be non-conforming to tradition and prejudicial to health, without scientific evidence and, exclusively, on basis of presumptions and religious prejudices. The facts give rise to some considerations on the methods and criteria for balancing the protection of the right to health, and self-determination in therapeutic choices, and the exercise of religious freedom in conditions of compromised mental health, and the risk of a reviving confessional in Lithuania.
description: Stato, Chiese e pluralismo confessionale, 2019: 13 maggio
GenV Vanguard Cohorts Protocol
Creators: name: Wake, Melissa
name: GOLDFELD, SHARON
name: Saffery, Richard
name: Siero, William
name: Hourani, Danah
name: Gulenc, Alisha
name: Hughes, Elizabeth
Publisher: name: Murdoch Childrens Research Institute
Year: 2020
Subjects: Health Sciences

description: The Generation Victoria (GenV) Vanguard Cohorts Protocol covers recruitment of participants at a small number of 'Vanguard' hospitals in 2020. It outlines the project design, recruitment approach, data collection, risk, data & biosample management and operational details. This is version three and was approved by the Human Research and Ethics Committee at the Royal Children’s Hospital in April 2020.
We would like to acknowledge the following people for their contributions (in alphabetical order): Katie Allen, Dino Asproloupos, Lynne Atley, David Burgner, Jim Buttery, John Carlin, Jeanie Cheong, Nigel Curtis, Sarah Davies, Ben Edwards, Lottie Gasparini, Harriet Hiscock, Karen Lamb, Joan Leong, Kathryn North, Anne-Louise Ponsonby, Joanne Said, Michael Stringer, and members of the GenV Focus Area and Method Cores Working Groups.
Le libre exercice du culte dans la République populaire de Chine (中華人民共和國)
Creators: name: Tigrino, Andrea
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2019

description: SOMMAIRE: 1. Une prémisse historique sur la Chine en tant que société multi-religieuse - 2. Les dispositions constitutionnelles relatives à la liberté de croyance avant 1982 - 3. La liberté religieuse dans l'actuelle Constitution de 1982 et la législation suivant en la matière - 4. Liberté religieuse et protection des droits de l'homme dans la Chine actuelle. The free exercise of Religion in People’s Republic of China ABSTRACT: After some historical reflections on the spread of multiple religious doctrines on the Chinese territory between the end of the XIX and the beginning of the XX century, the Author considers the attitude of the central government with respect to the right of religious freedom from the time of the Cultural Revolution to today, paying particular attention to the constitutional and criminal law provisions attached to this issue. It seems clear how the Chinese legal tradition is not based on a balance of interest theory as known in the Western legal systems, given the prevalence of the higher communist principles rooted in time. Last pages are reserved for the systematic violations of human rights reported by numerous international observatories, as well as the ancient grudge between China and the Holy See caused by the question of the appointment and formal recognition of new bishops. The provisional agreement signed on 22 September 2018, while marking a step towards finding a solution to this tensions, doesn’t offer a definitive solution to the problem.
description: Stato, Chiese e pluralismo confessionale, 2019: 13 maggio
Il delicato bilanciamento costituzionale fra libertà di parola e tutela del sentimento religioso: profili comparati
Creators: name: Testa Bappenheim, Stefano
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2019

description: SOMMARIO: 1. Premessa - 2. Il quadro costituzionale in Pakistan - 3. La tutela del sentimento religioso nel codice penale pakistano - 4. Il quadro costituzionale tedesco - 5. La tutela del sentimento religioso nel codice penale tedesco - 6. Conclusioni. The delicate constitutional Balance between Freedom of Speech and the Protection of religious Sentiment: comparative Profiles ABSTRACT: The article focuses on the issue of freedom of speech and freedom of religion from the point of view of two countries with specific legislation in place (Pakistan and Germany). In particular, we will examine the two Constitutions and the two Criminal Law, which proved to have very different ways of expressing their sensitivity and a great attention to the religious sentiment of the population.
description: Stato, Chiese e pluralismo confessionale, 2019: 20 maggio
Systemic deficiency of mouse arachidonate 15‐lipoxygenase induces defective erythropoiesis and transgenic expression of the human enzyme rescues this phenotype
Creators: name: Rademacher, Marlena
name: Kuhn, Hartmut
name: Borchert, Astrid
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: biomembranes
subject: differentiation
subject: eicosanoids
subject: lipid peroxidation
subject: redox equilibrium
subject: reticulocytes
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Arachidonic acid 15-lipoxygenases (ALOX15) are lipid peroxidizing enzymes, which has previously been implicated in the maturational breakdown of intracellular organelles and plasma membrane remodeling during reticulocyte-erythrocyte transition. Conventional Alox15−/− mice are viable, develop normally but do not exhibit a major defective erythropoietic phenotype. To characterize the putative in vivo relevance of Alox15 for red blood cell development, we explored the impact of systemic inactivation of the Alox15 gene on mouse erythropoiesis. We found that Alox15−/− mice exhibited reduced erythrocyte counts, elevated reticulocyte counts and red cell hyperchromia. The structure of the plasma membrane of Alox15−/− erythrocytes is altered and a significant share of the red cells was present as echinocytes and/or acanthocytes. An increased share of the Alox15−/− erythrocytes cells were annexin V positive, which indicates a loss of plasma membrane asymmetry. Erythrocytes of Alox15−/− mice were more susceptible to osmotic hemolysis and exhibited a reduced ex vivo life span. When we transgenically expressed human ALOX15 in Alox15−/− mice under the control of the aP2 promoter the defective erythropoietic system was rescued and the impaired osmotic resistance was normalized. Together these data suggest the involvement Alox15 in the maturational remodeling of the plasma membrane during red cell development.
Research conceptions of adult and college reader response to literature
Creators: name: Eberdt, Karen
Publisher: name: University of British Columbia
Year: 2011

description: "Response to literature" is an educational notion which generally refers to an oral or written reaction to a non-expository published work such as a short story or poem. This historical analysis investigates conceptions of response to literature in research with adults and college students. The dissertation problem derives from an apparent shift in emphasis from the text towards the reader in research on response to literature (Purves, 1985). The underlying assumption of this suggestion is that there are historically predominant research conceptions. This dissertation documents these ideas with adult and college readers' responses to literature. The procedure was first to establish foundation conceptions of "response" and "literature" from theoretical considerations of these terms. Next, studies derived from major bibliographies were examined in order to determine the general emphasis based on the research purpose, literary work, and response task. Predominant research conceptions of both "response" and "literature" were delineated by decades, from the first cited study in 1912. Results of the analysis concerned conceptions of both "literature" and "response". First, research conceptions of "literature" generally focused on print, rather than oral performance. In addition, there was a general research move from the use of meaningless syllables and fragments of poetry (1910-39); through the use of a diversity of genres such as newspaper articles, comprehension test items, and novels (1940-69); to a contemporary focus on short stories and poems (1970-89). Second, research conceptions of "response" supported the suggestion of a general shift from conceptions which focused on textual elements such as rhythm, sounds of language and literary merit (1920-39); through those which focused on aspects of the reader such as personality changes, preferences and developmental differences (1940-69) ; to those which emphasized elements of response itself such as process, stance, and context (1970-89). Possible reasons for the shifts in emphasis were explored in relation to general societal conditions and the changing image of the college student. From an educational perspective, the observed changes suggest a move towards empowerment of the learner in the classroom. This trend corresponds to the increasing pedagogical emphasis on holism and collaboration
Decision Support Tools for wastewater management and for water & land management in agriculture
Creators: name: Oertlé, Emmanuel
name: Dietziker, Andrin
name: Varela-Ortega, Consuelo
name: Boubakri, Najib
name: Blanco, Irene
name: Scardigno, Alessandra
name: Lamaddalena, Nicola
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2020
Subjects: ING-IND/25 Impianti chimici

description: This deliverable provides the description and the user guides for two Decision Support Tools (DSTs) relative to wastewater management and water & land management in agriculture, developed in the MADFORWATER project. The actual software and codes relative to these two DSTs have been deposited in open access repositories, and the corresponding links are reported in this deliverable. The first DST (Poseidon 2.0) compares different water-reuse options and it shows decision makers implementable solutions for wastewater treatment which comply with local requirements. It was developed in the framework of Task 5.2 of MADFORWATER - Strategies and economic instruments for WW management. Section 2.1 describes the DST and provides the links where it can be downloaded. A dedicated handbook explaining how to use the DST is included in Appendix I. The second DST is an integrated agro-economic model developed in Tasks 3.3 and 5.3, aimed at integrating water reuse and irrigation technologies (developed, tested and implemented in the MADFORWATER project) with economic instruments into basin-scale strategies to enhance the use of treated wastewater. Section 2.2 describes this DST and provides the links where it can be downloaded. A dedicated handbook explaining how to use the DST is included in Appendix II.
Self‐limited HBV infection of the recipient does not reactivate after liver transplantation: Observations from a 30‐year liver transplant program
Creators: name: Ossami Saidy, Ramin Raul
name: Demir, Muenevver
name: Nibbe, Pauline
name: Dobrindt, Eva‐Maria
name: Oellinger, Robert
name: Schoening, Wenzel
name: Pratschke, Johann
name: Eurich, Dennis
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: antiviral prophylaxis
subject: graft loss
subject: HBV reactivation
subject: liver transplantation
subject: resolved Hepatitis B infection
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: A self-limited hepatitis B infection can reactivate in patients under immunosuppression or chemotherapy (reappearance of hepatitis B surface antigen (HBsAg) or HBV-DNA). Exact circumstances of HBV reactivation in patients undergoing liver transplantation (LT) for end-stage liver diseases (ESLD) unrelated to HBV are unknown, and recommendations on HBV prophylaxis remain unclear. Patients and methods: Among 1273 liver transplants, 168 patients with a self-limited HBV hepatitis B infection prior to LT were identified from our prospective liver transplant database. Patients with underlying chronic HBV infection and recipients of an anti-HBc-positive liver were not included in the analysis. Demographic, laboratory, serological, and virological data were analyzed retrospectively. Appearance of HBsAg or HBV-DNA was defined as reactivation. Results: The median follow-up after LT was 12.0 years (0.6-30.7 years). The rate of HBV reactivation was 0% independent of antiviral prophylaxis (n = 7; 4.2%), the etiology of ESLD, hepatitis C treatment, or the anti-HBs concentration. The overall patient survival with a history of a self-limited HBV infection before LT did not significantly differ from the rest of the cohort. Conclusion: Antiviral treatment with nucleos(t)ide analogues post-liver transplantation in order to prevent HBV reactivation in patients with a resolved self-limited hepatitis B infection prior to LT seems to be omittable since the main viral reservoir is removed by the hepatectomy. These findings may clarify the current uncertainty in the recommendations regarding the risk of HBV reactivation in patients with self-limited hepatitis B prior to LT.
Appunti sulla circoncisione rituale nel diritto ecclesiastico e delle religioni
Creators: name: Borghi, Alex
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2019

description: SOMMARIO: 1. Premessa - 2. La giurisprudenza della Suprema Corte - 3. L’introduzione del § 1631, lett. d, nel BGB tedesco e la giurisprudenza di Colonia - 4. Risoluzioni e raccomandazioni del Consiglio d’Europa - 5. Il recente dibattito islandese - 6. Prospettive per l’Italia: necessità o ultroneità di una legge ad hoc? - 7. Osservazioni conclusive. Notes on ritual circumcision in Ecclesiastical and Religious Law. ABSTRACT: This paper deals with the delicate issue of ritual circumcision in Ecclesiastical and Religious Law. After having investigated the etymological origin of the word and reconstructed the history of the practice in question – distinguishing between circumcisions: a) therapeutic or prophylactic, b) ritual, c) cultural or ethnic – the focus is on the jurisprudential orientations of the Italian Court of Cassation. The solution proposed by the judgment of 24 November 2011, n. 43646, is carefully read and compared with the EU's law, the German legislation and the results of the recent Icelandic debate. Nevertheless, the absence of an ad hoc law on circumcision does not represent a vulnus in the Italian legal system, since the discipline can be found in the positive law in force, and even before in constitutional principles, as interpreted by the jurisprudence of merit and legitimacy. On the contrary, the essay raises the question that the introduction of a law on circumcision would not only be superfluous (for ethical and cultural reasons, even before legal ones), but also late".
description: Stato, Chiese e pluralismo confessionale, 2019: 25 marzo
Predictors of graft survival at diagnosis of antibody‐mediated renal allograft rejection: a retrospective single‐center cohort study
Creators: name: Waiser, Johannes
name: Klotsche, Jens
name: Lachmann, Nils
name: Wu, Kaiyin
name: Rudolph, Birgit
name: Halleck, Fabian
name: Liefeldt, Lutz
name: Bachmann, Friederike
name: Budde, Klemens
name: Duerr, Michael
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: antibody-mediated rejection
subject: graft survival
subject: immunosuppression
subject: renal function
subject: renal transplantation
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Antibody-mediated rejection (ABMR) is a major cause of graft loss in renal transplantation. We assessed the predictive value of clinical, pathological, and immunological parameters at diagnosis for graft survival. We investigated 54 consecutive patients with biopsy-proven ABMR. Patients were treated according to our current standard regimen followed by triple maintenance immunosuppression. Patient characteristics, renal function, and HLA antibody status at diagnosis, baseline biopsy results, and immunosuppressive treatment were recorded. The risk of graft loss at 24 months after diagnosis and the eGFR slope were assessed. Multivariate analysis showed that eGFR at diagnosis and chronic glomerulopathy independently predict graft loss (HR 0.94; P = 0.018 and HR 1.57; P = 0.045) and eGFR slope (beta 0.46; P < 0.001). Cyclophosphamide treatment (6x 15 mg/m²) plus high-dose intravenous immunoglobulins (IVIG) (1.5 g/kg) was superior compared with single-dose rituximab (1x 500 mg) plus low-dose IVIG (30 g) (HR 0.10; P = 0.008 and beta 10.70; P = 0.017) and one cycle of bortezomib (4x 1.3 mg/m(2)) plus low-dose IVIG (HR 0.16; P = 0.049 and beta 11.21; P = 0.010) regarding the risk of graft loss and the eGFR slope. In conclusion, renal function at diagnosis and histopathological signs of chronic ABMR seem to predict graft survival independent of the applied treatment regimen. Stepwise modifications of the treatment regimen may help to improve outcome.
Αξιολόγηση νεώτερων ινοτρόπων φαρμάκων στην αιμοδυναμική ανταπόκριση της οξείας καρδιακής ανεπάρκειας:
Creators: name: Αηδονίδης, Γεώργιος Θ.
Publisher: name: Aristotle University of Thessaloniki
Year: 2010
Subjects: Οξεία καρδιακή ανεπάρκεια
Λεβοσιμενδάνη
Μιλρινόνη
Αιμοδυναμική παρακολούθηση
Acute heart failure
Levosimendan
Milrinone
Hemodynamic monitoring

description: Σκοπός- Η σύγκριση της κλινικής έκβασης, της αιμοδυναμικής αποτελεσματικότητας, και της νευροορμονικής απόκρισης μεταξύ λεβοσιμενδάνης και μιλρινόνης στην μη αντιρροπούμενη χρόνια καρδιακή ανεπάρκεια με δοσολογικό σχήμα παρατεταμένης χορήγησης χωρίς δόση εφόδου. Μέθοδος- 50 ασθενείς προσκομιζόμενοι στα επείγοντα για οξεία ή μη αντιρροπούμενη χρόνια καρδιακή ανεπάρκεια, εντάχθηκαν στην μελέτη. Χωρίστηκαν σε δύο ισοδύναμες ομάδες λαμβάνουσες ενδοφλεβίως είτε λεβοσιμενδάνη είτε μιλρινόνη μέχρι και 72 ώρες χωρίς δόση εφόδου. Πρωτεύον τελικό σημείο ορίστηκε η αιμοδυναμική ανταπόκριση. Δευτερεύον τελικό σημείο αποτέλεσε η νευροορμονική και αρρυθμιογενετική ανταπόκριση των δύο φαρμάκων ανάλογα με το ΒΝΡ και τη διάρκεια του διηθημένου διαστήματος QRS αντίστοιχα, στις 48 και 72 ώρες. Κατεγράφησαν επιπλοκές και κλινική έκβαση στις 180 ημέρες. Αποτελέσματα- Αμφότερα τα φάρμακα παρουσίασαν καλή αιμοδυναμική ανταπόκριση, μείωση του ΒΝΡ και σταθερότητα του διηθημένου διαστήματος QRS. Η λεβοσιμενδάνη παρουσίασε παρατεταμένη ευεργετική νευροορμονική δράση με λιγότερες επαναεισαγωγές. Συμπεράσματα – Η παρατεταμένη χορήγηση λεβοσιμενδάνης ή μιλρινόνης χωρίς δόση εφόδου σε οξεία καρδιακή ανεπάρκεια αποτελεί αποτελεσματική στρατηγική.
description: Aim – To compare the hemodynamic efficiency, the neurohumoral response and the clinical outcome between levosimendan and milrinone in decompensated chronic heart failure using a prolonged infusion pattern without a loading dose. Method – 50 patients admitted to emergencies for acute or decompensated heart failure, participated in the study. They divided in two equivalent groups receiving intravenously either levosimendan or milrinone up to 72 hours without a loading dose. Primary endpoint was defined the hemodynamic response. Secondary endpoint was the neurohumoral and arrhythmiogenic response of the two agents according to BNP and QRS- complex duration (filtered) respectively, at 48 and 72 hours. Complications and clinical outcome within 180 days were registrated. Results – Both agents demonstrated good hemodynamic response, BNP decrease and QRS- complex duration stability. Levosimendan showed prolonged neurohumoral effect with less readmissions. Conclusions – Prolonged infusion of levosimendan or milrinone without a loading dose in acute heart failure is an effective management.
Brevi considerazioni a margine della proposta di legge n. 387 del 2018 “Disposizioni concernenti l’esposizione del Crocifisso nelle scuole e nelle pubbliche amministrazioni”
Creators: name: Baldassarre, Silvia
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2019

description: SOMMARIO: 1. Premessa − 2. Quadro normativo di riferimento ­− 3. Sulla valenza culturale del crocifisso − 4. Laicità, imparzialità, neutralità dei luoghi pubblici - 5. La rimozione dei crocifissi: una condotta da sanzionare? - 6. Osservazioni conclusive. Draft law n. 387/18, “Provisions concerning the crucifix exhibition in schools and public administrations”: brief reflections. ABSTRACT: The draft law n. 387 of March 26, 2018, (obligation to expose the Crucifix in schools and public administrations), is part of a complex legal-constitutional context of relations between state and religious phenomenon, characterized by multiple unresolved issues and problematic profiles. The law refers to the theory of cultural and identity value of the symbol, sustained with continuity by the administrative jurisprudence in disputes concerning the regulations governing the exposure of the crucifix. The questionability of this hermeneutical perspective, largely outdated, is clear and evident if we consider the most current judgments on the subject. The most critical issues of the current proposal will be examined.
description: Stato, Chiese e pluralismo confessionale, 2019: 1 aprile
Roper Commercial Poll: Youth Survey
Creators: name: Organization, The Roper
Publisher: name: Roper Center for Public Opinion Research
Year: 2021

description: Most fun time in life (2); favorite actors (2); favorite actresses (2); favorite radio program (1); favorite comic character (1); magazine readership (9); favorite sport (1); favorite recreational activity (1); friendliness toward foreign countries (4); self-support (1); church attendance (2); importance of church (2); parents' church attendance (2); irritating parents (4); differing opinions with parents (11); closest friend (7); role model (7); famous role model (2); items used by various people (9); items used by respondent (9); potential items used (3); usage at home (9); cigarette brand (2); lipstick brand (2); beverage preferences (4); hot tea preparation (1); parents' hot tea preparation (2); favorite drinks of various groups (8); better drink for health (1); college plans (1); work plans (1); father's occupation (1); expected age of marriage (1).
Eicosanoid biosynthesis in marine mammals
Creators: name: Reisch, Florian
name: Kakularam, Kumar Reddy
name: Stehling, Sabine
name: Heydeck, Dagmar
name: Kuhn, Hartmut
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: eicosanoids
subject: epidermal differentiation
subject: evolution
subject: fatty acids
subject: lipoxygenases
subject: oxidative stress
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: After 300 million years of evolution, the first land-living mammals reentered the marine environment some 50 million years ago. The driving forces for this dramatic lifestyle change are still a matter of discussion but the struggle for food resources and the opportunity to escape predators probably contributed. Reentering the oceans requires metabolic adaption putting evolutionary pressure on a number of genes. To explore whether eicosanoid signaling has been part of this adaptive response, we first explored whether the genomes of marine mammals involve functional genes encoding for key enzymes of eicosanoid biosynthesis. Cyclooxygenase (COX) and lipoxygenase (ALOX) genes are present in the genome of all marine mammals tested. Interestingly, ALOX12B, which has been implicated in skin development of land-living mammals, is lacking in whales and dolphins and genes encoding for its sister enzyme (ALOXE3) involve premature stop codons and/or frameshifting point mutations, which interrupt the open reading frames. ALOX15 orthologs have been detected in all marine mammals, and the recombinant enzymes exhibit similar catalytic properties as those of land-living species. All marine mammals express arachidonic acid 12-lipoxygenating ALOX15 orthologs, and these data are consistent with the Evolutionary Hypothesis of ALOX15 specificity. These enzymes exhibit membrane oxygenase activity and introduction of big amino acids at the triad positions altered the reaction specificity in favor of arachidonic acid 15-lipoxygenation. Thus, the ALOX15 orthologs of marine mammals follow the Triad concept explaining their catalytic specificity.
Mutilazioni genitali femminili: la lotta dell’Europa contro una silenziosa violenza
Creators: name: Di Iorio, Tiziana
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2019

description: SOMMARIO: 1. Le pratiche di manipolazioni degli organi genitali femminili - 2. Procedura esercutiva e conseguenze degli atti di alterazione dei caratteri sessuali delle donne - 3. Radici socio-culturali delle pratiche di MGF - 4. Fattore religioso e atti modificativi dei genitali femminili - 5. Le strategie di prevenzione e di contrasto delle MGF nell’Unione europea - 6. Politiche legislative nella lotta contro le MGF - 7. Conclusioni. Denied identities. Female genital mutilation: the fight of Europe against a silent violence ABSTRACT: FGM refers to rituals of manipulation female genitalia and other procedures against female genital organs for non-medical reasons. Usually the practice is carried out on young girls, from childhood to teenagers. These rituals are carried out for cultural, religious and social reasons in the mistaken belief that they will produce a benefit to the girl (to safeguard her virginity, to prepare for marriage, etc.). No religious text prescribes the practice, but is rooted in the culture and beliefs of the communities that practice it. However some religious communities practice the FGM. Rituals do not help the health of the girl subjected, but they can lead to serious health complications or even to death of victim. So FGM is recognised a form of child abuse and a violation of women’s human rights. The EU is committed to eliminating FGM through strategic actions and legislative measures, but mainly changes in attitudes and beliefs among relevant communities are important to ensure FGM is abandoned. It is also important to fight FGM with direct involvement of the religious and political leaders of the communities where the rituals are diffuse. European States are called to cooperate with each other with strategic internal and external actions.
description: Stato, Chiese e pluralismo confessionale, 2019: 1 aprile
Organizzazioni di tendenza religiosa tra Direttiva europea, diritti nazionali e Corte di giustizia UE
Creators: name: Floris, Pierangela
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2019

description: SOMMARIO: 1. Premessa - 2. La Direttiva 2000/78 CE e i casi Egenberger e IR arrivati a Lussemburgo - 3. Autonomia delle chiese e tutela giurisdizionale dei diritti all’interno delle organizzazioni religiosamente orientate. I contenuti criptici delle pronunce di Lussemburgo - 4. Il requisito ideologico nelle organizzazioni di tendenza. Le integrazioni della Corte UE e le riletture in corso da parte confessionale - 5. L’art. 17 TFUE e l’attesa di chiarimenti. Religious-Ethos Employers between European Directive, national laws and Court of Justice EU ABSTRACT: This article examines two recent rulings of the Court of Justice of the European Union (cases Egenberger and IR). These are the first rulings on art. 4, par. 2, Directive 2000/78/EC on “occupational activities within churches and other public or private organisations the ethos of which is based on religion or belief“. On the one hand the author focuses on the passages concerning religious autonomy and jurisdictional protection of rights; on the other hand she highlights the links between the jurisprudence of the two European courts (CJEU and ECHR) and tries to reconcile the statements of the Court of Justice and those of the German constitutional Court on the limits to the autonomy of churches. However, the article highlights how the Court of Justice has not adequately addressed neither the art. 10 of the European Charter of Fundamental Rights EU, nor the art. 17 of the TFEU. As regards the ideological requirement set by art. 4, par. 2 of the European Directive, the study focuses on the additions made by the Court of Justice and recalls the reinterpretations of the ideological requirement recently adopted by the Catholic and Evangelical Churches in Germany.
description: Stato, Chiese e pluralismo confessionale, 2019: 1 aprile
The acquisition of a written language by E.S.L. children during the kindergarten and grade one years
Creators: name: Chow, Mayling
Publisher: name: University of British Columbia
Year: 2010

description: This research investigates the development of writing in children who are learning English as a second language (ESL). Its underlying hypotheses are that: 1) ESL children will learn to write independently when placed in a social and psychological setting that facilitates language learning; and 2) they will use the same strategies and follow the same general patterns of development as those reported for English-speaking children. Current research on emergent literacy provided the theoretical framework for this study. This investigation followed eleven ESL children from the beginning of Kindergarten to the end of Grade One. The children's writing samples were collected daily and were analyzed and classified within Gentry's (1982) stages of writing development. The data were examined for implied strategies, knowledge and understandings. Observational notes on the children when writing revealed characteristics and behaviours found at each level of writing development. The results point to the similarities between how ESL children and English-speaking children learn to write when challenged to discover the English writing system for themselves. The theoretical perspective of writing as a developmental process was evident throughout the study. Additional findings highlighted the significant role of literature in ESL learning and the importance of a learner-centred approach to literacy instruction. The implications of the research findings for ESL methodology is discussed together with an account of the children's development in writing.
Riflessioni sul processo di nullità matrimoniale nel contesto della delibazione in Italia
Creators: name: Mioli, Graziano
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2019

description: SOMMARIO: 1. Premessa - 2. L'art. 60 del Decreto generale sul matrimonio canonico della CEI e l’obbligo di delibare - 3. La fase dell’indagine pregiudiziale e quella introduttiva - 4. La fase istruttoria e quella discussoria - 5. La fase decisoria - 5.1. Della redazione della sentenza - 5.2. Dell’interferenza delle questioni patrimoniali - 6. Conclusioni. Reflections on marriage nullity proceedings in the context of the Italian exequatur procedure ABSTRACT: The obligation to request the exequatur of the ecclesiastical sentence of marriage nullity, foreseen by the art. 60 of the General decree on the canonical matrimony of the CEI, constitutes in Italy a legal duty for the faithful who determines, for judges and lawyers, a corresponding moral duty (but which for lawyers can also become legal, under the professional mandate) of collaboration, during the various prejudicial and judicial phases of the canonical proceedings, in acquiring and making available all the useful elements in view of a exequatur procedure.
description: Stato, Chiese e pluralismo confessionale, 2019: 8 aprile
Preformed donor‐reactive T cells that persist after ABO desensitization predict severe T cell‐mediated rejection after living donor kidney transplantation – a retrospective study
Creators: name: Schachtner, Thomas
name: Stein, Maik
name: Otto, Natalie M.
name: Reinke, Petra
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: ABO desensitization
subject: donor-reactive T cells
subject: immunosuppression
subject: kidney transplantation
subject: rituximab
subject: T cell-mediated rejection
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Preformed donor-reactive T cells are relatively resistant to standard immunosuppression and account for an increased incidence of T cell-mediated rejection (TCMR) and inferior kidney allograft outcomes. We analyzed 150 living donor kidney transplant recipients (KTRs) of a first kidney allograft. Ninety-eight ABO-compatible (ABOc) and 52 ABO-incompatible (ABOi) KTRs were included. Samples were collected at 6 time points, before rituximab, before immunoadsorption and pretransplantation, at +1, +2, and +3 months posttransplantation, and donor-reactive T cells were measured by interferon-gamma ELISPOT assay. Twenty of 98 ABOc (20%) and 12 of 52 ABOi KTRs (23%) showed positive pretransplant ELISPOT. Eight of 20 ABOc-KTRs (40%) with positive pretransplant ELISPOT showed TCMR, whereas 17 of 78 ABOc-KTRs (22%) with negative pretransplant ELISPOT did (P = 0.148). Seven of 12 ABOi KTRs (57%) with positive pretransplant ELISPOT showed TCMR, whereas only 3 of 40 ABOi KTRs (8%) with negative pretransplant ELISPOT did (P < 0.001). Interestingly, 6 of 7 ABOi KTRs with positive pretransplant ELISPOT that persists after ABO desensitization developed TCMR. Among 118 KTRs with negative pretransplant ELISPOT, 10 of 72 ABOc-KTRs (14%), but 0 of 46 ABOi KTRs, developed positive posttransplant ELISPOT (P = 0.006). Preformed donor-reactive T cells that persist despite ABO desensitization identify KTRs at highest risk of TCMR. Less de-novo donor-reactive T cells after ABO desensitization may account for less TCMR. Both, the use of rituximab and early initiation of calcineurin inhibitor-based maintenance immunosuppression may contribute to these findings.
Προοπιτκή μελέτη παρέμβασης με στόχο τη διερεύνηση του ρόλου της εντατικής εκπαίδευσης στη βελτίωση της συμμόρφωσης των γλαυκωμάτων ασθενών:
Creators: name: Γεωργιάδου-Στεφανίδου, Ειρήνη Ν.
Publisher: name: Aristotle University of Thessaloniki
Year: 2010
Subjects: Συμμόρφωση
Μη συμμόρφωση
Γλαύκωμα
Εκπαίδευση
Adhecence
Glaucoma
Non compliamce
Compliance

description: Σκοπός: Η μελέτη του ρόλου της εκπαίδευσης στη συμμόρφωση στο γλαύκωμα. Ασθενείς και Μέθοδοι: Οι ασθενείς διαχωρίστηκαν σε δύο ομάδες την ομάδα παρέμβασης Α και την ομάδα ελέγχου Β. Στους ασθενείς της ομάδας της παρέμβασης πραγματοποιήθηκε εκπαίδευση όπου οι ασθενείς ενημερώθηκαν για την φύση του γλαυκώματος και την αξία της συμμόρφωσης στην θεραπευτική αγωγή. Στους ασθενείς της ομάδας ελέγχου αφιερώθηκε ίσος χρόνος διδασκαλίας με την ομάδα παρέμβασης η εκπαίδευση όμως αφορούσε θέματα γύρω από τη υγεία των οφθαλμών. Έγινε μέτρηση της πρωινής ΕΟΠ στους 1, 3, 6, 9 και 12 μήνες, του ποσοστού της συμμόρφωσης και της αποτελεσματικότητας της θεραπείας. Αποτελέσματα: Στη μελέτη αυτή συμμετείχαν δύο ομάδες 51 ασθενείς στη ομάδα παρέμβασης και 54 στη ομάδα ελέγχου. Υπήρξε ελάττωση της ΕΟΠ σε όλους τους ασθενείς καθόλη τη διάρκεια της μελέτης ενώ το ποσοστό της μέσης μείωσης της ΕΟΠ ήταν ιδιαίτερα υψηλό στους ασθενείς της ομάδας παρέμβασης. Από τη στατιστική ανάλυση φάνηκε ότι το ποσοστό συμμόρφωσης ήταν στατιστικώς σημαντικά πιο υψηλό στους ασθενείς της ομάδας παρέμβασης με μεγαλύτερη διαφορά ανάμεσα στις δύο ομάδες να είναι το 18,7% στους 6 μήνες. Συμπεράσματα: Χρειάζεται προσπάθεια για να βελτιωθεί η συμμόρφωση εστιάζοντας περισσότερο στην εκπαίδευση των ασθενών και στη βελτιωμένη επικοινωνία ιατρού-ασθενούς.
description: Aim: To study the role of intensive training in the rate of adherence in glaucoma. Patients and methods: Patients were randomized into 2 groups intervention group A and attention placebo group B. Patients in the intervention group received intensive one hour teaching on the nature of glaucoma, the value of IOP control and the importance of adherence. Patients in the attention placebo group received equal teaching time focusing on the importance of good eye health and protection, prevention of cataract and macular degeneration but no details on either glaucoma or adherence. All patients had a complete ophthalmological examination. Primary study objectives were morning IOP control between groups at 1, 3, 6, 9, 12, the rate of adherence Results: The outcomes of the statistic analysis regarding the IOP control showed a significant decrease of the mean IOP in both groups during the study. The rate of the mean IOP was lower in the intervention group. Another outcome that was examined in the study was the rate of adherence. The results of the statistic analysis showed that adherence rate was significantly higher in the intervention group, with greatest difference of 18, 7 % between the two groups at 6 months. Conclusions: An effort needs to be done in order to improve compliance focusing in the education of the patients and improving doctor-patient relationship. This will lead in a better and more successful management of chronic diseases.
Νόμοσ e συνεἱδησiς: dall'Antigone di Sofocle all'ordinamento canonico
Creators: name: Serra, Beatrice
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2019

description: SOMMARIO: 1. Perché Antigone: la tragedia di Sofocle come paradigma per ricostruire il rapporto tra legge e coscienza nel diritto canonico - 2. La dinamica degli opposti tra dimensione giuridica e dimensione politica. Perenne attualità di tale dinamica. In particolare: a) Il contrasto tra lex e ius. Il legame tra l’Antigone e le vicende della legge positiva come fonte del diritto -3. (segue) b) Il contrasto tra ragion di Stato e affetti privati - 4. Il lutto quale esito dell’antinomia tra legge e coscienza nell’Atene del V secolo. Ragioni di tale esito: a) assenza di efficaci elementi di ricomposizione del contrasto tra valori assoluti rappresentati da Antigone e Creonte. Assenza di ogni forma di mediazione del contrasto giuridico tra lex e ius - 5. (segue) b) L’intrinseca fragilità della scelta di Antigone: il richiamo al dato divino in funzione delle proprie istanze affettive. L’assenza di una concezione della coscienza quale autonoma dimensione interiore del singolo capace di fondare la violazione delle leggi della polis - 6. (segue) c) L’ineludibile esecuzione delle norme in contrasto. Antigone e Creonte privi di libertà di scelta davanti alla legge - 7. Dalle “assenze” nel rapporto tra legge e coscienza dell’Antigone alle “presenze” che connotano tale rapporto nell’assetto giuridico canonico. In particolare: a) La mediazione tra ius e lex come dimensione costitutiva della giuridicità ecclesiale - 8. (segue) b) La Sapienza divina quale oggettivo elemento di sintesi del contrasto tra legge e coscienza nella Chiesa - 9. (segue) c) La coscienza cristiana come struttura morale originaria che rispecchia la volontà divina dalla quale trae la forza di resistere alla norma - 10. (segue) d) La libertà umana quale presupposto irrinunciabile del rapporto tra legge e coscienza. Il giudizio della coscienza cristiana come testimone interiore che rende l’uomo responsabile dell’adempimento o inadempimento della norma. Νόμοσ and συνεἱδησiς: from Sophocles' Antigone to the canonical order ABSTRACT: The contribution reconstructs the essential lines of the relationship between law and conscience in Canon law starting from a re-reading of Sophocles's Antigone.
description: Stato, Chiese e pluralismo confessionale, 2019: 8 aprile
Metabolic heterogeneity of human hepatocellular carcinoma: implications for personalized pharmacological treatment
Creators: name: Berndt, Nikolaus
name: Eckstein, Johannes
name: Heucke, Niklas
name: Wuensch, Tilo
name: Gajowski, Robert
name: Stockmann, Martin
name: Meierhofer, David
name: Holzhütter, Hermann‐Georg
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: kinetic modeling
subject: liver
subject: mathematical model
subject: metabolism
subject: tumor metabolism
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Metabolic reprogramming is a characteristic feature of cancer cells, but there is no unique metabolic program for all tumors. Genetic and gene expression studies have revealed heterogeneous inter- and intratumor patterns of metabolic enzymes and membrane transporters. The functional implications of this heterogeneity remain often elusive. Here, we applied a systems biology approach to gain a comprehensive and quantitative picture of metabolic changes in individual hepatocellular carcinoma (HCC). We used protein intensity profiles determined by mass spectrometry in samples of 10 human HCCs and the adjacent noncancerous tissue to calibrate Hepatokin1, a complex mathematical model of liver metabolism. We computed the 24-h profile of 18 metabolic functions related to carbohydrate, lipid, and nitrogen metabolism. There was a general tendency among the tumors toward downregulated glucose uptake and glucose release albeit with large intertumor variability. This finding calls into question that the Warburg effect dictates the metabolic phenotype of HCC. All tumors comprised elevated β-oxidation rates. Urea synthesis was found to be consistently downregulated but without compromising the tumor's capacity for ammonia detoxification owing to increased glutamine synthesis. The largest intertumor heterogeneity was found for the uptake and release of lactate and the size of the cellular glycogen content. In line with the observed metabolic heterogeneity, the individual HCCs differed largely in their vulnerability against pharmacological treatment with metformin. Taken together, our approach provided a comprehensive and quantitative characterization of HCC metabolism that may pave the way for a computational a priori assessment of pharmacological therapies targeting metabolic processes of HCC.
Novità processuali in materia di nullità matrimoniale e giurisdizione canonica
Creators: name: Tigano, Marta
name: Galluccio, Mariangela
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2019

description: SSOMMARIO: 1. La riforma del processo matrimoniale nel solco del cammino sinodale della Chiesa … - 2. … e nel segno della Tradizione. Interpretazione sistematica della nuova normativa e principio dell’indissolubilità del matrimonio - 3. Le radici storiche del processus brevior: la “Episcopalis audientia” - 4. La “parabola” della “Episcopalis audientia”: contenuto e disciplina - 5. La “centralità” del Vescovo oggi come ieri - 6. La doppia sentenza conforme nell’ordinamento canonico … - 7 … e la sua evoluzione storico-giuridica: dalle origini fino al XX secolo - 8. La doppia sentenza conforme nelle Codificazioni del XX secolo - 9. La celerità dei giudizi e la pastorale della famiglia al centro della Riforma di Papa Francesco - 10. “Innovare nella tradizione: sfida e compito del canonista”. Procedural novelties regarding marriage nullity and canonical jurisdiction ABSTRACT: The purpose of the essay is to investigate the changes made to the discipline of the canonical process of marriage nullity by the Motu Proprio “Mitis Iudex Dominus Iesus”, in an attempt to verify whether the reform - which, as we know, has foreseen, among the other novelties, a shorter trial before the Bishop, and the elimination of the double sentence in conformity - both in line with the imprint proper to the canonical jurisdiction. In this perspective, the study will be dedicated to the historical reconstruction of the Processus brevior coram Episcopo and of the institute of the c.d. double sentence in conformity, at the end of which it seems possible to point out that the devolution to the Bishop of a shorter judgment - and the consequent reduction of the procedural forms - should not have undermined the cardinal principles of canonical jurisdiction.
description: Stato, Chiese e pluralismo confessionale, 2019: 8 aprile
Control of neutrophil influx during peritonitis by transcriptional cross‐regulation of chemokine CXCL1 by IL‐17 and IFN‐γ
Creators: name: Catar, Rusan A.
name: Chen, Lei
name: Cuff, Simone M.
name: Kift‐Morgan, Ann
name: Eberl, Matthias
name: Kettritz, Ralph
name: Kamhieh‐Milz, Julian
name: Moll, Guido
name: Li, Qing
name: Zhao, Hongfan
name: Kawka, Edyta
name: Zickler, Daniel
name: Parekh, Gita
name: Davis, Paul
name: Fraser, Donald J.
name: Dragun, Duska
name: Eckardt, Kai‐Uwe
name: Jörres, Achim
name: Witowski, Janusz
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: mesothelial cells
subject: CXCL1
subject: IL-17
subject: IFN-γ
subject: peritonitis
subject: peritoneal dialysis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Neutrophil infiltration is a hallmark of peritoneal inflammation, but mechanisms regulating neutrophil recruitment in patients with peritoneal dialysis (PD)-related peritonitis are not fully defined. We examined 104 samples of PD effluent collected during acute peritonitis for correspondence between a broad range of soluble parameters and neutrophil counts. We observed an association between peritoneal IL-17 and neutrophil levels. This relationship was evident in effluent samples with low but not high IFN-γ levels, suggesting a differential effect of IFN-γ concentration on neutrophil infiltration. Surprisingly, there was no association of neutrophil numbers with the level of CXCL1, a key IL-17-induced neutrophil chemoattractant. We investigated therefore the production of CXCL1 by human peritoneal mesothelial cells (HPMCs) under in vitro conditions mimicking clinical peritonitis. Stimulation of HPMCs with IL-17 increased CXCL1 production through induction of transcription factor SP1 and activation of the SP1-binding region of the CXCL1 promoter. These effects were amplified by TNFα. In contrast, IFN-γ dose-dependently suppressed IL-17-induced SP1 activation and CXCL1 production through a transcriptional mechanism involving STAT1. The SP1-mediated induction of CXCL1 was also observed in HPMCs exposed to PD effluent collected during peritonitis and containing IL-17 and TNFα, but not IFN-γ. Supplementation of the effluent with IFN-γ led to a dose-dependent activation of STAT1 and a resultant inhibition of SP1-induced CXCL1 expression. Transmesothelial migration of neutrophils in vitro increased upon stimulation of HPMCs with IL-17 and was reduced by IFN-γ. In addition, HPMCs were capable of binding CXCL1 at their apical cell surface. These observations indicate that changes in relative peritoneal concentrations of IL-17 and IFN-γ can differently engage SP1–STAT1, impacting on mesothelial cell transcription of CXCL1, whose release and binding to HPMC surface may determine optimal neutrophil recruitment and retention during peritonitis.