cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Lyot-based Ultra-Fine Pointing Control System for Phase Mask Coronagraphs
Creators: name: Singh, Garima
name: Martinache, Frantz
name: Baudoz, Pierre
name: Guyon, Olivier
name: Matsuo, Taro
name: Clergeon, Christophe
Publisher: name: arXiv
Year: 2013
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: High performance coronagraphic imaging at small inner working angle requires efficient control of low order aberrations. The absence of accurate pointing control at small separation not only degrades coronagraph starlight rejection but also increases the risk of confusing planet's photons with starlight leaking next to the coronagraph focal plane mask center. Addressing this issue is essential for preventing coronagraphic leaks, and we have thus developed a new concept, the Lyot-based pointing control system (LPCS), to control pointing errors and other low order aberrations within a coronagraph. The LPCS uses residual starlight reflected by the Lyot stop at the pupil plane. Our simulation has demonstrated pointing errors measurement accuracy between 2-12 nm for tip-tilt at 1.6 micron with a four quadrant phase mask coronagraph.
description: 7 pages, 5 figures, Proceedings of AO4ELTs3 conference, Paper 12667, Florence, Italy, May 2013
High Frequency of and Factors Associated with Thyroid Hormone Over-Replacement and Under-Replacement in Men and Women Aged 65 and Over
Creators: name: Somwaru, Lily L.
name: Arnold, Alice M.
name: Joshi, Neha
name: Fried, Linda P.
name: Cappola, Anne R.
Publisher: name: Columbia University
Year: 2009
Subjects: Thyroid hormones--Therapeutic use
Older people
Endocrinology
Aging
Epidemiology

description: Context: Thyroid hormone use is common in older populations, but the frequency of over- or under-replacement is debated. Objective: We sought to describe the frequency of and factors associated with thyroid hormone over- or under-replacement in a population of older men and women. Design: Participants were 3678 U.S. community dwelling individuals aged 65 yr or older enrolled in the Cardiovascular Health Study who had thyroid function tests in 1989–1990. Thyroid hormone users (n = 339) were identified and classified into low TSH (<0.45 mU/liter), euthyroid (0.45–4.5 mU/liter), and high TSH (>4.5 mU/liter). Results: Of the 339 thyroid hormone users, 41% had a low TSH, 16% had a high TSH, and 43% were in the euthyroid range. In multivariable analyses, lower weight (P < 0.001) was independently associated with low TSH status. For every 10 kg lower weight, the likelihood of having low TSH increased by 65% [odd ratio (OR) 1.65; 95% confidence interval (CI) 1.31–2.07]. Those with renal insufficiency were less likely to have low TSH levels (P = 0.02). The presence of diabetes was independently associated with having low (OR 3.35; 95% CI 1.46–7.65) and high TSH levels (OR 2.66; 95% CI 1.14–6.21). Conclusions: There is a very high prevalence of thyroid function testing abnormalities in older people taking thyroid hormone preparations, particularly in those of low weight or with diabetes. Because of potential adverse cardiovascular and skeletal effects from over-replacement, older people represent a key population for increased TSH monitoring on therapy.
Determinacy and indeterminacy of games played on complete metric spaces
Creators: name: Fishman, Lior
name: Ly, Tue
name: Simmons, David S.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Logic (math.LO)
subject: FOS: Mathematics

description: Schmidt's game is a powerful tool for studying properties of certain sets which arise in Diophantine approximation theory, number theory, and dynamics. Recently, many new results have been proven using this game. In this paper we address determinacy and indeterminacy questions regarding Schmidt's game and its variations, as well as more general games played on complete metric spaces (e.g. fractals). We show that except for certain exceptional cases, these games are undetermined on Bernstein sets.
Alan Keith Graham (1934–2021)
Creators: name: Jaramillo, Carlos
name: Jarzen, David M.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Hematology
subject: 60506 Virology

description: Alan Keith Graham (1934–2021)
Higher Serum Testosterone Concentration in Older Women is Associated with Insulin Resistance, Metabolic Syndrome, and Cardiovascular Disease
Creators: name: Patel, Shrita M.
name: Ratcliffe, Sarah J.
name: Reilly, Muredach P.
name: Weinstein, Rachel
name: Bhasin, Shalender
name: Blackman, Marc R.
name: Cauley, Jane
name: Sutton-Tyrrell, Kim
name: Robbins, John
name: Fried, Linda P.
name: Cappola, Anne R.
Publisher: name: Columbia University
Year: 2009
Subjects: Testosterone--Physiological effect
Coronary heart disease
Insulin resistance
Metabolic syndrome
Older women
Endocrinology
Aging
Epidemiology

description: Context: Early postmenopausal women with higher testosterone (T) levels have increased insulin resistance (IR) and cardiovascular risk factors, but whether this translates into increased cardiovascular disease later in life is unknown. Objective: The objective of the study was to determine whether higher T levels are associated with IR, the metabolic syndrome (MetSyn), and coronary heart disease (CHD) in elderly women. Design: Total T and free T by equilibrium dialysis were measured using ultrasensitive assays in 344 women aged 65–98 yr enrolled in the Cardiovascular Health Study. Cross-sectional analyses were performed to examine the associations between total and free T and IR, MetSyn, and CHD. Results: There was a stepwise increase in the homeostasis model assessment of insulin resistance with increasing total (P = 0.0.003) and free T (P = 0.02) level and a corresponding decrease in Quantitative Insulin Sensitivity Check Index (P < 0.001 and P = 0.002, respectively). In adjusted models, higher levels of both total and free T were strongly associated with abdominal obesity and high fasting glucose, the two MetSyn components most strongly linked to IR. After adjustment, women in the top quartile of total T levels had a 3-fold greater odds of MetSyn (odds ratio 3.15, 95% confidence interval 1.57–6.35) than those in the bottom quartile and a 3-fold greater odds of CHD (odds ratio 2.95, 95% confidence interval 1.2–7.3) than those in second quartile, whereas free T was not significantly associated with MetSyn or CHD. Conclusions: Higher levels of T are associated with IR, MetSyn, and CHD in elderly women. Whether T is a marker or mediator of cardiovascular disease in this population merits further investigation.
Analog and digital codes in the brain
Creators: name: Mochizuk, Yasuhiro
name: Shinomoto, Shigeru
Publisher: name: arXiv
Year: 2013
Subjects: subject: Neurons and Cognition (q-bio.NC)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: It has long been debated whether information in the brain is coded at the rate of neuronal spiking or at the precise timing of single spikes. Although this issue is essential to the understanding of neural signal processing, it is not easily resolved because the two mechanisms are not mutually exclusive. We suggest revising this coding issue so that one hypothesis is uniquely selected for a given spike train. To this end, we decide whether the spike train is likely to transmit a continuously varying analog signal or switching between active and inactive states. The coding hypothesis is selected by comparing the likelihood estimates yielded by empirical Bayes and hidden Markov models on individual data. The analysis method is applicable to generic event sequences, such as earthquakes, machine noises, human communications, and enhances the gain in decoding signals and infers underlying activities.
description: 10 pages, 7 figures
Determinants of Serum Total and Free Testosterone Levels in Women over the Age of 65 Years
Creators: name: Cappola, Anne R.
name: Ratcliffe, Sarah J.
name: Bhasin, Shalender
name: Blackman, Marc R.
name: Cauley, Jane
name: Robbins, John
name: Zmuda, Joseph M.
name: Harris, Tamara
name: Fried, Linda P.
Publisher: name: Columbia University
Year: 2007
Subjects: Testosterone
Older women
Endocrinology
Aging
Epidemiology

description: Context: Little is known about testosterone (T) levels and their determinants in women of late postmenopausal age. Objective: We describe levels of total and free T and selected factors that influence these levels in a random sample of older women. Design: Levels of serum total T and free T by microdialysis were measured using ultrasensitive assays in 347 community-dwelling women aged 65–98 yr enrolled in the Cardiovascular Health Study. Cross-sectional analyses were performed to define factors associated with total and free T levels. Results: In adjusted models: 1) total T levels declined with age until 80, whereas free T levels did not vary by age; 2) women with bilateral oophorectomy had 23% lower total T and 16% lower free T levels than those with at least one intact ovary; 3) oral estrogen users had total and free T levels that were 47% lower than never users; 4) obese women had 47% higher total T and 20% higher free T levels, and overweight women had 24% higher total T and 14% higher free T levels, than normal weight women; and 5) free T levels were 51% higher in black women. Corticosteroid users had 75% lower total T and 43% lower free T levels than nonusers. Conclusions: Bilateral oophorectomy, estrogen use, corticosteroid use, and low body mass index are independent risk factors for lower T levels in women aged 65 yr and over. Although highly prevalent in women of this age, the physiological significance of low T levels in late postmenopausal women requires further investigation.
Investigating the Role of Electric Fields on Flow Harmonics in Heavy-Ion Collisions
Creators: name: Panda, Ankit Kumar
name: Gangadharan, Reghukrishnan
name: Roy, Victor
Publisher: name: arXiv
Year: 2023
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Using the blast-wave model, we explore the effect of electric fields on spectra and flow harmonics (especially the elliptic flow) for charged pions and protons. We incorporate the first-order correction to the single-particle distribution function due to the electric fields and the dissipative effect while calculating the invariant yields of hadron in the Cooper-Frey prescription at the freezeout hypersurface. We find a noticeable correction to the directed and elliptic flow of pions and protons for unidirectional and azimuthal asymmetric electric fields in the transverse plane of magnitude $\sim m_π^{2}$. Further, we observe mass dependency of the directed flow generated due to the electric fields. The splitting of particle and antiparticle's elliptic flow is also discussed.
description: 10 pages, 8 figures
Higgs Couplings in Composite Models
Creators: name: Montull, Marc
name: Riva, Francesco
name: Salvioni, Ennio
name: Torre, Riccardo
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study Higgs couplings in the composite Higgs model based on the coset SO(5)/SO(4). We show that the couplings to gluons and photons are insensitive to the elementary-composite mixings and thus not affected by light fermionic resonances. Moreover, at leading order in the mixings the Higgs couplings to tops and gluons, when normalized to the Standard Model (SM), are equal. These properties are shown to be direct consequences of the Goldstone symmetry and of the assumption of partial compositeness. In particular, they are independent of the details of the elementary-composite couplings and, under the further assumption of CP invariance, they are also insensitive to derivative interactions of the Higgs with the composite resonances. We support our conclusions with an explicit construction where the SM fermions are embedded in the 14 dimensional representation of SO(5).
description: 13 pages, 3 figures, 2 tables; v2: small improvements in the discussion, results unchanged; typos corrected; one reference added. Matches version submitted to PRD
Insulin-Like Growth Factor I and Interleukin-6 Contribute Synergistically to Disability and Mortality in Older Women
Creators: name: Cappola, Anne R.
name: Xue, Qian-Li
name: Ferrucci, Luigi
name: Guralnik, Jack M.
name: Volpato, Stefano
name: Fried, Linda P.
Publisher: name: Columbia University
Year: 2003
Subjects: Aging--Endocrine aspects
Aging--Physiological aspects
Older women
Endocrinology
Aging
Epidemiology

description: The physiology of age-related functional decline is poorly understood, but may involve hormones and inflammation. We hypothesized that older women with both low IGF-I and high IL-6 levels are at high risk for disability and death. We assessed walking speed and disability in 718 women enrolled in the Women’s Health and Aging Study I, a 3-yr cohort study with 5-yr mortality follow-up. Women with IGF-I levels in the lowest quartile and IL-6 levels in the highest quartile had significantly greater limitation in walking and disability in mobility tasks and instrumental activities of daily living than those with neither risk factor (adjusted odds ratios, 10.77, 5.14, and 3.66). Women with both risk factors were at greater risk for death (adjusted relative risk, 2.10) as well as incident walking limitation, mobility disability, and disability in activities of daily living compared with those with high IGF-I and low IL-6 levels. The combination of low IGF-I and high IL-6 levels confers a high risk for progressive disability and death in older women, suggesting an aggregate effect of dysregulation in endocrine and immune systems. The joint effects of IGF-I and IL-6 may be important targets for treatments to prevent or minimize disability associated with aging.
Association of IGF-I Levels with Muscle Strength and Mobility in Older Women
Creators: name: Cappola, Anne R.
name: Bandeen-Roche, Karen
name: Wand, Gary S.
name: Volpato, Stefano
name: Fried, Linda P.
Publisher: name: Columbia University
Year: 2001
Subjects: Walking--Physiological aspects
Older women
Endocrinology
Aging

description: The functional consequences of the age-associated decline in IGF-I are unknown. We hypothesized that low IGF-I levels in older women would be associated with poor muscle strength and mobility. We assessed this question in a population representative of the full spectrum of health in the community, obtaining serum IGF-I levels from women aged 70–79 yr, enrolled in the Women’s Health and Aging Study I or II. Cross-sectional analyses were performed using 617 women with IGF-I levels drawn within 90 d of measurement of outcomes. After adjustment for age, there was an association between IGF-I and knee extensor strength (P = 0.004), but not anthropometry or other strength measures. We found a positive relationship between IGF-I levels and walking speed for IGF-I levels below 50 μg/liter (P < 0.001), but no relationship above this threshold. A decline in IGF-I level was associated with self-reported difficulty in mobility tasks. All findings were attenuated after multivariate adjustment. In summary, in a study population including frail and healthy older women, low IGF-I levels were associated with poor knee extensor muscle strength, slow walking speed, and self-reported difficulty with mobility tasks. These findings suggest a role for IGF-I in disability as well as a potential target population for interventions to raise IGF-I levels.
The Role of Education and Intellectual Activity on Cognition
Creators: name: Parisi, Jeanine M.
name: Rebok, George W.
name: Xue, Qian-Li
name: Fried, Linda P.
name: Seeman, Teresa E.
name: Tanner, Elizabeth K.
name: Gruenewald, Tara L.
name: Frick, Kevin D.
name: Carlson, Michelle C.
Publisher: name: Columbia University
Year: 2012
Subjects: Cognition--Research
Education
Cognition
Epidemiology

description: Although educational attainment has been consistently related to cognition in adulthood, the mechanisms are still unclear. Early education, and other social learning experiences, may provide the skills, knowledge, and interest to pursue intellectual challenges across the life course. Therefore, cognition in adulthood might reflect continued engagement with cognitively complex environments. Using baseline data from the Baltimore Experience Corps Trial, multiple mediation models were applied to examine the combined and unique contributions of intellectual, social, physical, creative, and passive lifestyle activities on the relationship between education and cognition. Separate models were tested for each cognitive outcome (i.e., reading ability, processing speed, memory). With the exception of memory tasks, findings suggest that education-cognition relations are partially explained by frequent participation in intellectual activities. The association between education and cognition was not completely eliminated, however, suggesting that other factors may drive these associations.
British Columbia Legislative Assembly sessional clipping book (1932-02)
Creators: name: :Unav
Publisher: name: University of Victoria Libraries
Year: 2022
Subjects: subject: British Columbia. Legislative Assembly
valueUri: http://id.worldcat.org/fast/600765
subject: Politics and government
valueUri: http://id.worldcat.org/fast/1919741
subject: Law
valueUri: http://id.worldcat.org/fast/993678
subject: FOS: Law

description: These Sessional Clippings books cover the period 1891 to 1972, and include newspaper accounts written by various legislative reporters who covered debates occurring in the British Columbia Legislative Assembly. Transcripts of debates of the Legislative Assembly (Hansard) were not published in B.C. until 1970; hence these "Sessional Clipping Books" augment the "Journals", the record of daily proceedings of the Legislative Assembly. Selected clippings from various newspapers including the Vancouver Sun, the Vancouver Province, the Colonist, and the Times newspapers, relating to the newspaper reports concerning activities of the Legislature. The original sessional clippings books comprise 351 ledger size print volumes, held at the Legislative Library in Victoria BC. The print volumes were microfilmed onto 26 reels in 1977 under a Tri University Libraries (TRIUL) project by Precision Micrographic Services (Vancouver, B.C.), with the permission of the Legislative Library, Victoria, British Columbia. This digital collection was created by scanning the 26 microfilm reels.
ExPaNDS FAIR for facilities workshop
Creators: name: Köhler, Martin
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2020

description: ExPaNDS FAIR for facilities workshop, virtuell, DESY, virtuell, 1 Oct 2020 - 1 Oct 2020
description: Linking publication and data; Some thoughts on “When to assign a DOI”; The journal of large scale facilities
title: Threshold Processes and Stream Temperature Distribution in a Small New England Headwater Stream Catchment.
Creators: name: isaacson, mitchell
Publisher: name: University of Massachusetts Amherst
Year: 2020

description: Rising air temperature and decreasing stream flow trends are predicted to result in corresponding increases in stream temperatures. As a result, the future of ectothermic stream fishes, which rely on seasonal and spatial distributions of stream temperature for growth and survival, could be in jeopardy. Fortunately, contradicting stream temperature trends in forested headwater catchments suggest that non-climatic variables, such as baseflow indices and catchment geologic structure, may have an important confounding influence on the future of stream temperature. Most significantly, the annual stability of groundwater temperature has long been recognized as an important buffer between air and stream temperature. The hyporheic zone has been the subject of an emerging focus of new research over the past decade and breakthroughs in our understanding in groundwater and surface water interactions have given rise to new conceptual frameworks in hydrology. Once such framework is the concept of threshold discharge in which inputs to streams are activated once critical metrics are met in antecedent moisture, rainfall intensity, and rising water tables in the riparian areas and topographical depressions. This study investigates the extent to which threshold connectivity between soil saturation, groundwater, precipitation, and streamflow exist in a shallow bedrock/till-mantled headwater catchment, and how threshold characteristics may influence the fluid flux and temperature variability of the stream. This study uses stable water isotopes, fiber-optic distributed temperature sensing, and hydrometric analyses to observe the fluid and heat flux within the catchment. The results indicate that threshold discharge is an inherent property of the saturated soil conductivity curve which drives macropore and fractured-bedrock discharge into the stream. The sequential activation of flow in fractured storage reservoirs and soil can be observed in the isotopic, temperature, and conductivity measurements of the stream. Fiber-optic distributed temperature sensing (FO-DTS) produced the locations of both discrete seeps in areas with bedrock outcrops and thin overburden, and diffuse seeps where thicker alluvial deposits occurred. The net effect of threshold discharge events on seep locations was a reduction of the instream temperature variability and decrease in the persistence of thermal refugia, or seeps buffered from the main stream channel temperature.
p38 Protects Human Melanoma Cells from UV-Induced Apoptosis Through Down-Regulation of NF-κB Activity and Fas Expression
Creators: name: Ivanov, Vladimir N.
name: Ronai, Ze'ev
Publisher: name: Columbia University
Year: 2000
Subjects: Melanoma
Apoptosis
Cytology
Oncology

description: Identifying mechanisms that underlie the resistance of human melanoma to radiation and chemotherapy is expected to assist in developing new strategies for the treatment of this tumor type. We recently demonstrated that through up-regulation of TNFα, ATF2 increases the resistance of late stage melanoma cells to apoptosis induced by UV-irradiation. In elucidating the role of ATF2 kinases, we now demonstrate that ASK1/MKK6/p38 elicits suppression of Fas expression. ASK1/p38 downregulates the expression of a Fas via NF-κB/SP1 site on the Fas promoter. Deletion or mutation of NF-κB/SP1 within the Fas promoter abrogates p38 effect. ASK1/p38 silences the Fas promoter by inhibition of IκBα phosphorylation - thereby limiting NF-κB activity. Forced expression of a dominant negative form of p38 (p38-ASP) or treatment with p38 pharmacological inhibitor, SB203580, increases NF-κB activity, Fas expression and the levels of UVC-induced apoptosis in late stage melanoma cells. Inhibition of p38 activity also restored NF-κB activity and Fas expression in early-phase melanoma cells, suggesting that p38 elicited suppression of Fas expression is not restricted to late phase melanoma. Identifying p38-mediated down-regulation of Fas expression illustrates a novel regulatory pathway by which ASK1/MKK6/p38 alters the degree and nature of the UV-induced apoptosis of melanoma cells.
Evidence for a correlation between the sizes of quiescent galaxies and local environment to z ~ 2
Creators: name: Lani, Caterina
name: Almaini, Omar
name: Hartley, William G.
name: Mortlock, Alice
name: Haeussler, Boris
name: Chuter, Robert W.
name: Simpson, Chris
name: van der Wel, Arjen
name: Grutzbauch, Ruth
name: Conselice, Christopher J.
name: Bradshaw, Emma J.
name: Cooper, Michael C.
name: Faber, Sandra M.
name: Grogin, Norman A.
name: Kocevski, Dale D.
name: Koekemoer, Anton M.
name: Lai, Kamson
Publisher: name: arXiv
Year: 2013
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present evidence for a strong relationship between galaxy size and environment for the quiescent population in the redshift range 1 < z < 2. Environments were measured using projected galaxy overdensities on a scale of 400 kpc, as determined from ~ 96,000 K-band selected galaxies from the UKIDSS Ultra Deep Survey (UDS). Sizes were determined from ground-based K-band imaging, calibrated using space-based CANDELS HST observations in the centre of the UDS field, with photometric redshifts and stellar masses derived from 11-band photometric fitting. From the resulting size-mass relation, we confirm that quiescent galaxies at a given stellar mass were typically ~ 50 % smaller at z ~ 1.4 compared to the present day. At a given epoch, however, we find that passive galaxies in denser environments are on average significantly larger at a given stellar mass. The most massive quiescent galaxies (M_stellar > 2 x 10^11 M_sun) at z > 1 are typically 50 % larger in the highest density environments compared to those in the lowest density environments. Using Monte Carlo simulations, we reject the null hypothesis that the size-mass relation is independent of environment at a significance > 4.8 sigma for the redshift range 1 < z < 2. In contrast, the evidence for a relationship between size and environment is much weaker for star-forming galaxies.
description: Accepted for publication in MNRAS. 16 pages, 11 figures, 6 tables
Carrollian Yang-Mills Theory
Creators: name: Islam, Minhajul
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: By doing a small $c$ (speed of light) expansion of $SU(N)$ Yang-Mills fields, we construct two different electric and two different magnetic sectors actions of Carrollian Yang-Mills theory. For both electric and magnetic cases, one sector contains non-trivial self-interaction, and another is $N^2-1$ copies of respective sector Carrollian abelian theory. In $d=4$ , all the four sectors are invariant under infinite Carrollian Conformal symmetry. There are no central extensions when analyzing charge algebra at the phase space level. Lastly, we compute propagators for all four sectors and vertices for two non-trivial sectors. Propagators in position space show ultra-local behavior.
description: 38 pages, 4 figures
CroMaSt: A workflow for domain family curation through cross-mapping of structural instances between protein domain databases
Creators: name: Hrishikesh Dhondge
name: De Beauchene, Isaure Chauvot
name: Marie-Dominique Devignes
Publisher: name: F1000 Research Limited
Year: 2022

description: Protein domains can be viewed as building blocks, essential for understanding structure-function relationships in proteins. However, each domain database classifies protein domains using its own methodology. Thus, in many cases, boundaries between different domains or families differ from one domain database to the other, raising the question of domain definition and enumeration. The answer to this question cannot be found in a single database. Rather, expert integration and curation of various databases are required to refine the contours of a domain of interest, in a domain-centric approach.
 Here, we illustrate the role of 3-D structure in clarifying domain definition with the help of CroMaSt: “Cross-Mapper for Structural Domains”, a fully automated workflow that classifies all structural instances of a given domain into 3 different categories (core, true and domain-like). CroMaSt is developed in Common Workflow Language (CWL) and takes advantage of 2 well-known and widely used domain databases, Pfam (sequence-based) and CATH (structure-based). It uses the domain definitions from Pfam and CATH and SIFTS resource for cross-mapping of structural instances from the above-mentioned sources. Structural alignments generated by Kpax allow to identify the false positive instances from each domain database.
 We tested CroMaSt on the RNA Recognition Motif (RRM), the most prevalent and diverse RNA-binding domain. Starting from PF00076 and 3.30.70.330 domain families from Pfam and CATH respectively, our workflow identifies 882 core, 1120 true and 89 domain-like structural instances. The information generated by this method will play a crucial role in machine learning methods applied to domain-specific synthetic biology.
Role of TRAF2/GCK in Melanoma Sensitivity to UV-Induced Apoptosis
Creators: name: Ivanov, Vladimir N.
name: Kehrl, John H.
name: Ronai, Ze'ev
Publisher: name: Columbia University
Year: 2000
Subjects: Melanoma
Apoptosis
Cytology
Oncology

description: Radiation resistance is a hallmark of human melanoma, and yet mechanisms underlying this resistance are not well understood. We recently established the role of ATF2 in this process, suggesting that stress kinases, which contribute to regulation of ATF2 stability and activity, play an important role in the acquisition of such resistance. Here we demonstrate that changes in the expression and respective activities of TRAF2/GCK occur during melanoma development and regulate its sensitivity to UV-induced apoptosis. Comparing early- and late-stage melanoma cells revealed low expression of TRAF2 and GCK in early-stage melanoma, which coincided with poor resistance to UV-induced, TNF-mediated apoptosis; forced expression of GCK alone or in combination with TRAF2 efficiently increased JNK and NF-κB activities, which coincided with increased protection against apoptosis. Conversely, forced expression of the dominant negative form of TRAF2 or GCK in late-stage melanoma cells reduced NF-κB activity and decreased Fas expression, resulting in a lower degree of UV-induced, Fas-mediated cell death. Our results illustrate a mechanism in which protection from, or promotion of, UV-induced melanoma cell death depends on the nature of the apoptotic cascade (TNF or Fas) and on the availability of TRAF2/GCK, whose expression increases during melanoma progression.
title: Constituirende National-Versammlung; [1848]
title: Die Herren Abgeordneten zur constituirenden National-Versammlung werden dringend ersucht: alsbald nach ihrem Eintreffen in hiesiger Stadt bei der Commission im Sarasin'schen Hause, und zwar von Morgens 9 bis 12 und Mittags von 3 bis 5 Uhr sich anmelden zu wollen ; Frankfurt am Main den 16. Mai 1848
titleType: Subtitle
Creators: name: (:Unav)
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2018

description: Kopftitel. - Flugblatt
title: Impact of Parity on Gait Biomechanics
Creators: name: Stein, Bekah P
Publisher: name: University of Massachusetts Amherst
Year: 2020

description: IMPACT OF PARITY ON GAIT BIOMCECHANICS
MAY 2020
BEKAH P. STEIN, B.A., UNIVERSITY OF MASSACHUSETTS AMHERST
M.A., UNIVERSITY OF MASSACHUSETTS AMHERST
Directed by: Professor Katherine A. Boyer
Background: Symptomatic knee osteoarthritis (OA) is an incurable condition that affects nearly 50% of adults, and women are twice as likely as men to develop OA. Throughout pregnancy, women experience large changes in morphology and gait mechanics, as well as changes in joint loading. It is possible these adaptations could cause lasting changes postpartum, which may potentially contribute to initiation of OA, thereby increasing the overall risk of OA for women.
Purpose: This exploratory study looked to identify differences between lower limb gait mechanics of healthy nulliparous women and healthy parous women.
Methods: 28 healthy female participants (14 parous, 14 nulliparous) were recruited for the study. Nulliparous participants had never given birth to a child, and were self-reported not pregnant. Parous participants had given birth to at least one full term infant (37 – 42 weeks) without complications between one to five years before data collection. Kinematic and kinetic data was collected for the lower body, using motion capture and in-ground force plates. Participants completed one quiet standing trial, and walked over-ground through the motion capture space at their preferred, fast, and set walking speeds (1.4 m/s). An ANOVA was performed to test if there were significant differences in between groups.
Results: Q angle did not differ between groups. There was a significant main effect of group indicating a larger knee flexion angle at toe off (p = 0.060), smaller knee extension moment at heel strike (p = 0.0006), smaller first peak knee flexion moment (p = 0.040), and smaller peak hip adduction moment for the parous group compared to the nulliparous group (p = 0.003).
Conclusions: Our data revealed a decrease in the moments experienced, which could possibly lead to degradation of cartilage due to under loading of the joint. We think this may be an indication that pregnancy could increase risk of OA, and therefore more research into this possibility is warranted. 
A knowledge graph approach for interpretable prediction of pathogenic genetic interactions
Creators: name: Renaux, Alexandre
name: Terwagne, Chloé
name: Cochez, Michael
name: Tiddi, Ilaria
name: Nowé, Ann
name: Lenaerts, Tom
Publisher: name: F1000 Research Limited
Year: 2022

description: An increasing number of clinical studies are reporting patterns of oligogenic inheritance in genetic diseases. Despite the advent of methods able to predict the pathogenicity of variant combinations, the underlying biological mechanisms remain unknown, since these models offer limited interpretability. To advance towards a better understanding of oligogenic disease aetiology, we developed a new interpretable predictive method based on a knowledge graph. This heterogenous network integrates curated oligogenic combinations together with multiple biological networks and biomedical ontologies. Our approach successfully captures association rules solely based on multi-hop relationships between genes. It combines them as a decision set model which can predict the pathogenicity of new gene pairs. These predictions come with explanations, obtained by querying the knowledge graph, which highlight relevant paths. The benchmarking of this model in a cross-validation setting achieves high accuracy and recalls independent gene pairs from recently published digenic combinations. The analysis of the rule-based paths highlights relevant contributors to the disease and shows the ability of this approach to generate knowledge-based hypotheses to investigate new disease mechanisms.
MPEC 2023-M42 : 2023 MK
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 MK

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Global excitability and network structure in the human brain
Creators: name: Kora, Youssef
name: Salhi, Salma
name: Davidsen, Jörn
name: Simon, Christoph
Publisher: name: arXiv
Year: 2023
Subjects: subject: Neurons and Cognition (q-bio.NC)
subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: We utilize a model of Wilson-Cowan oscillators to investigate structure-function relationships in the human brain by means of simulations of the spontaneous dynamics of brain networks generated through human connectome data. This allows us to establish relationships between the global excitability of such networks and global structural network quantities for connectomes of two different sizes for a number of individual subjects. We compare the qualitative behavior of such correlations between biological networks and shuffled networks, the latter generated by shuffling the pairwise connectivities of the former while preserving their distribution. Our results point towards a remarkable propensity of the brain's to achieve a trade-off between low network wiring cost and strong functionality, and highlight the unique capacity of brain network topologies to exhibit a strong transition from an inactive state to a globally excited one.
description: 12 pages, 10 figures
title: SDPD-SX: a methodology for powder diffraction data collection for structure solution
Creators: name: Ross, Marta Joan
Publisher: name: University of Reading
Year: 2023

description: Determination of structural information from diffraction patterns of crystalline materials can enable and enhance many ‘high impact’ areas of chemistry including the development of materials for photovoltaics, hydrogen storage cells and battery materials. In this thesis, drug discovery and drug development is explored with respect to their use of structural information. Given that these processes utilise conformational and packing information to enhance all stages of their development; from lead identification to formulation. The earlier conformational information is obtained within these processes, the greater potential impact on the direction of a project within these areas. Furthermore, in many cases, it is not feasible to grow single crystals, large enough what they are suitable for single crystal X-ray diffraction (SCXRD). Powder X-ray diffraction is the best alternative but unfortunately, a standard powder diffraction set up requires at least 10 mg of sample, which is simply not available at the early stages of drug development programmes. In this thesis, a trial of 81 small organic compounds found that, after multiple recrystallisations, 25 compounds produced one or more samples that were crystalline but were unsuitable for SCXRD. This thesis presents a method for the routine powder diffraction data collection using an in�house single crystal diffractometer with < 0.1 mg of polycrystalline sample. The process of optimising of a single crystal diffractometer for optimal powder data collection is described. This method combines the use of powder diffraction data collected on a standard, lab-based single crystal diffractometer (SDPD-SX) using DASH, an open-source global optimisation structure solution approach. The applicability of the method is also demonstrated through a wide range of molecular and crystallographic complexity, with particular focus on compounds of pharmaceutical interest. SDPD-SX enabled the crystal structure determination from limited samples of a range of known and novel crystal structures. Novel structures were validated using DFT-D energy minimisation.
title: Reproductive Factors and Postmenopausal FSH Levels
Creators: name: Costa, Rebecca
Publisher: name: University of Massachusetts Amherst
Year: 2020

description: Recent studies have shown that postmenopausal follicle stimulating hormone (FSH) levels may be predictive of future cardiovascular disease risk. However, little is known about postmenopausal FSH levels, including the level of variation between women and factors associated with this variation. We assessed the relationship of multiple reproductive factors with FSH levels among 588 postmenopausal women in the Kuopio Ischemic Heart Disease Risk Factor Study. Participants were aged 53 to 73 years and not using hormone therapy at baseline (1998-2001). Reproductive factors were assessed at baseline, along with FSH levels. After adjustment for sex steroids, adiposity measures, plasma lipids, blood pressure, and behavioral factors, we observed that women with 3 or more births and an age at first birth of 25 or later had mean FSH levels that were significantly 7.6 IU/L lower than those of women with a 1 to 2 births and an age at first birth of 24 or less. Number of miscarriages was inversely correlated with FSH levels. Women reporting a 7 or more years of OC use and 4-6 or 7 or more years of HT use each had significantly higher mean FSH levels than women who had never used OCs or HT. In summary, multiple reproductive factors were associated with postmenopausal FSH levels, independent of estradiol, adiposity, and other factors. These findings warrant replication and further exploration of potential underlying mechanism.
British Columbia Legislative Assembly sessional clipping book (1932-01)
Creators: name: :Unav
Publisher: name: University of Victoria Libraries
Year: 2022
Subjects: subject: Law
valueUri: http://id.worldcat.org/fast/993678
subject: FOS: Law
subject: Politics and government
valueUri: http://id.worldcat.org/fast/1919741
subject: British Columbia. Legislative Assembly
valueUri: http://id.worldcat.org/fast/600765

description: These Sessional Clippings books cover the period 1891 to 1972, and include newspaper accounts written by various legislative reporters who covered debates occurring in the British Columbia Legislative Assembly. Transcripts of debates of the Legislative Assembly (Hansard) were not published in B.C. until 1970; hence these "Sessional Clipping Books" augment the "Journals", the record of daily proceedings of the Legislative Assembly. Selected clippings from various newspapers including the Vancouver Sun, the Vancouver Province, the Colonist, and the Times newspapers, relating to the newspaper reports concerning activities of the Legislature. The original sessional clippings books comprise 351 ledger size print volumes, held at the Legislative Library in Victoria BC. The print volumes were microfilmed onto 26 reels in 1977 under a Tri University Libraries (TRIUL) project by Precision Micrographic Services (Vancouver, B.C.), with the permission of the Legislative Library, Victoria, British Columbia. This digital collection was created by scanning the 26 microfilm reels.
title: Ueberreicht durch den Abgeordneten von Reden. An die hohe deutsche National-Versammlung zu Frankfurt a. M. Unterthäniger Antrag der gehorsamst unterzeichneten Saline-Besitzer und Saline-Interessenten im Königreich Hannover, Supplicanten, betreffend die Freigebung des Salzhandels für ganz Deutschland; [1848]
title: Hannover und Eldagsen, den 19. Juli 1848
titleType: Subtitle
Creators: name: Reden, Friedrich Wilhelm von
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2018

description: Kopftitel
Gaussian-state Ansatz for the non-equilibrium dynamics of quantum spin lattices
Creators: name: Menu, Raphaël
name: Roscilde, Tommaso
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The study of non-equilibrium dynamics is one of the most important challenges of modern quantum many-body physics, in relationship with fundamental questions in quantum statistical mechanics, as well as with the fields of quantum simulation and computing. In this work we propose a Gaussian Ansatz for the study of the nonequilibrium dynamics of quantum spin systems. Within our approach, the quantum spins are mapped onto Holstein-Primakoff bosons, such that a coherent spin state -- chosen as the initial state of the dynamics -- represents the bosonic vacuum. The state of the system is then postulated to remain a bosonic Gaussian state at all times, an assumption which is exact when the bosonic Hamiltonian is quadratic; and which is justified in the case of a nonlinear Hamiltonian if the boson density remains moderate. We test the accuracy of such an Ansatz in the paradigmatic case of the $S=1/2$ transverse-field Ising model, in one and two dimensions, initialized in a state aligned with the applied field. We show that the Gaussian Ansatz, when applied to the bosonic Hamiltonian with nonlinearities truncated to quartic order, is able to reproduce faithfully the evolution of the state, including its relaxation to the equilibrium regime, for fields larger than the critical field for the paramagnetic-ferromagnetic transition in the ground state. In particular the spatio-temporal pattern of correlations reconstructed via the Gaussian Ansatz reveals the dispersion relation of quasiparticle excitations, exhibiting the softening of the excitation gap upon approaching the critical field. Our results suggest that the Gaussian Ansatz correctly captures the essential effects of nonlinearities in quantum spin dynamics; and that it can be applied to the study of fundamental phenomena such as quantum thermalization and its breakdown.
Additional file 1 of Prevalence and risk factors for laminitis within the Norwegian pony breed Nordlandshest/Lyngshest
Creators: name: Lykkjen, Sigrid
name: Stenbakk, Linda Koldal
name: Holmøy, Ingrid Hunter
Publisher: name: figshare
Year: 2023
Subjects: subject: Neuroscience
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Questionnaire distributed to members of the Norwegian Nordlandshest/Lyngshest breed association.
Adiabatic Approximation, Semiclassical Scattering, and Unidirectional Invisibility
Creators: name: Mostafazadeh, Ali
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Mathematical Physics (math-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The transfer matrix of a possibly complex and energy-dependent scattering potential can be identified with the $S$-matrix of a two-level time-dependent non-Hermitian Hamiltonian H(t). We show that the application of the adiabatic approximation to H(t) corresponds to the semiclassical description of the original scattering problem. In particular, the geometric part of the phase of the evolving eigenvectors of H(t) gives the pre-exponential factor of the WKB wave functions. We use these observations to give an explicit semiclassical expression for the transfer matrix. This allows for a detailed study of the semiclassical unidirectional reflectionlessness and invisibility. We examine concrete realizations of the latter in the realm of optics.
description: 15 pages, 1 figure, 1 table, expanded version to appear in J. Phys. A
Additional file 1 of Cellphone laws and teens’ calling while driving: analysis of repeated cross-sectional surveys in 2013, 2015, 2017, and 2019
Creators: name: Li, Li
name: Pope, Caitlin N.
name: Andridge, Rebecca R.
name: Bower, Julie K.
name: Guoqing Hu
name: Motao Zhu
Publisher: name: figshare
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Additional file 1.
Regulation of Fas-Dependent Activation-Induced T cell Apoptosis by cAMP Signaling: A Potential Role for Transcription Factor NF-κB
Creators: name: Ivanov, Vladimir N.
name: Lee, Richard K.
name: Podack, Eckhard R.
name: Malek, Thomas R.
Publisher: name: Columbia University
Year: 1997
Subjects: T cells
Apoptosis
Cytology
Oncology

description: TCR-mediated activation of T cell hybridomas induces programmed cell death by a Fas-dependent pathway. We now show that costimulation of 2B4 cells, in the absence or presence of transgenic Bcl-2, with anti-CD3epsilon and forskolin, an activator of cAMP signaling, resulted in antagonism of Fas-dependent activation-induced cell death that was always accompanied by selective down-regulation of the nuclear levels of NF-κB p65-p50 (RelA-p50) transcription factor. Forskolin not only inhibited activation-induced cell death and NF-κB activation, but also suppressed expression of Fas and Fas ligand (Fas-L). Furthermore, NF-κB p65 antisense oligonucleotide down-regulated nuclear levels of NF-κB, inhibited cell surface expression of Fas-L and apoptosis of 2B4. Collectively, these finding demonstrate a potential role of NF-κB in the regulation of activation-induced apoptosis in T lymphocytes.