cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Fischer 344 spinal cord contusion model and effects of cyclosporin-A on the model
Creators: name: Hsu, Shao-Yun
Publisher: name: No Publisher Supplied
Year: 2016

description: The Multicenter Animal Spinal Cord Injury Study (MASCIS) standardized spinal cord injury (SCI) in Long-Evans hooded and Sprague-Dawley rats. In this thesis, we extended the MASCIS model to Fischer 344 (F344) rats for the following reasons. First, F344 rats are immune-compatible with each other.  Cells can be transplanted from one F344 rat to another without immunosuppression. Second, our laboratory developed a strain of F344 rats that express green fluorescent protein (GFP).  When transplanted into regular F344 rats, GFP F344 rat cells can be readily identified. Third, F344 rats are isogenic. They should have more uniform and replicable responses to injury and therapies. Finally, this F344 model allows us to assess effects of allogeneic cell transplants with and without immunosuppressive drugs, such as cyclosporin-A (CsA), as well as the effects of immunosuppressive drugs on transplanted cells. We chose to assess olfactory ensheathing glial (OEG) cell transplants because many investigators have reported that these cells improve motor recovery in rat SCI models. Our results show that F344 rats can be reproducibly injured with the MASCIS model and that OEG transplants significantly improve locomotor recovery when transplanted without CsA.  However, we encountered several unexpected findings. Female rats recovered more than male rats even though the animals were age-matched, studies of the spinal cords revealed no difference in size and anatomy of age-matched male and female rats, and 24-hour lesion volumes in male and female spinal cords were the same. OEG transplants improved recovery of male rats, almost as well as untreated female rats.  CsA therapy improved recovery in both male and female rats. We conclude that the MASCIS model causes reproducible injury to spinal cords of F344 rats, age-matched female rats recover better locomotor function than male rats, OEG cells can be transplanted from GFP F344 rats to wild-type F344 rats without immune rejection, OEG transplants improve functional recovery particularly in male rats, CsA improved locomotor recovery in both male and female F344 rats.  The MASCIS impactor model should be very useful for assessing mechanisms underlying gender differences, OEG and CsA effects on transplanted cells and recovery mechanisms.
The forms of nature
Creators: name: Hunt, Stephanie Elizabeth
Publisher: name: No Publisher Supplied
Year: 2016

description: This dissertation examines how ideas drawn from early modern poetics were integral to narratives of the founding moments of political obligation that shaped the development of sixteenth- and seventeenth-century political thought. George Puttenham claimed that the origins of all political communities derived from the work of the poet: “poesie” came “before any civil society was among men”; moreover, it was the “original cause and occasion of their first assemblies.” For early modern writers, pastoral in particular exemplified poetry’s ability to frame ways of thinking about political communities and their origins. Poets such as Spenser, Shakespeare, Marvell, and Milton recognized that pastoral’s depictions of landscapes that were removed from the centers of power allowed them to trace representations of what I call “extrapolitical” moments in early modern literature: forms of collective life that arise outside normative institutional structures and imagine alternative foundations for political membership. Spenser’s Faerie Queene shows that allegorical reading takes the place of legal judgment within its lawless romance and pastoral terrains, while exile in Shakespeare’s As You Like It forces characters excluded from the court to invent new ideas of collective obligation through the resources of pastoral drama. Marvell’s Upon Appleton House and Milton’s Paradise Lost experiment with pastoral lyric conventions to imagine idyllic domestic spaces and relationships that expand theological arguments about prelegal forms of government. These writers use pastoral not merely as a genre, defined by its recognizable figures, themes, and situations, but as a mode of inquiry that penetrated a wide range of literary forms, from epic, to allegorical romance, georgic, and lyric. Furthermore, pastoral served as a versatile apparatus for examining how concerns central to literary studies – including invention, mediation, and affect – were integral to political philosophy’s claims about the sources of our obligations to other humans and to the natural world.
Agenysa lacertosa Sekerka 2016, comb. nov.
Creators: name: Sekerka, Lukáš
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Chrysomelidae
Agenysa
Agenysa lacertosa

description: Agenysa lacertosa (Boheman, 1862) comb. nov.
Mesomphalia lacertosa Boheman, 1862: 164 (original description).
Agenysa crassicornis Spaeth, 1905: 94 (original description), syn. nov.
Type localities. Agenysa crassicornis: ‘ Brasilien, Kolumbien, Ekuador:Archidona, Coca’; Mesomphalia lacertosa: ‘Peruvia’.
Type material. Agenysa crassicornis: SYNTYPES: 1 ♂, pinned, ‘Columbia | Staud. d. [w, hw by Spaeth, cb] || crassicornis | type ♂ m. [w, hw by Spaeth, cb] || TYPE [r, p, cb] || M/CR MUS | SPAETH COLL. [w, p, cb] || Manchester Museum | Syntype [blue, p, cb] ’ (MMUE); 1 ♀, pinned, ‘ Columbien [w, hw, cb] || Columbia | Staud. d. [w, hw by Spaeth, cb] || crassicornis | type ♀ m. [w, hw by Spaeth, cb] || TYPE [r, p, cb] || M/CR MUS | SPAETH COLL. [w, p, cb] || Manchester Museum | Syntype [blue, p, cb]’ (MMUE).
Mesomphalia lacertosa: HOLOTYPE: ♂, pinned, ‘ Type [w, p, s, c, rf] || Peru [hw] | Baly Coll. | 1905—54. [w, p, cb] || Mesomphalia | lacertosa | Boh | Peru [w, hw by Baly, cb] || Stevens | named by | Boheman | Type [hw by Baly on underside of preceding label] ’ (BMNH).
Remarks. Mesomphalia lacertosa was unknown to subsequent authors and was listed only in catalogues. Only, SPAETH (1914) transferred it to Pseudomesomphalia Spaeth, 1901 (= Stolas). I have examined its type and found that it is conspecific with A. crassicornis differing only by the elytra being more black than dark olive green. I therefore synonymize it with the latter species.
SPAETH (1905) differentiated A. crassicornis from other species by the very dark olive green to almost black dorsum and thicker antennae. These characters were followed by VIANA (1968). I have studied numerous additional specimens and it seems that the thicker antennae depend on the size of the specimen. Large specimens of similar species such as A. peruviana Spaeth, 1916 have similarly thick antennae and basically the only character that separates them is mostly black colour. Also, some specimens of A. lacertosa have more or less indicated little red pieces of reticulation on explanate margin of elytra and are quite similar to A. calvata. It is possible that A. calvata, A. lacertosa and A. peruviana are just forms of a single species distributed in the Andes. For the time being I keep them as separate species because this problem requires complex analysis of extensive material combined with molecular data.
Distribution. Brazil, Colombia, Ecuador (SPAETH 1905), and Peru (BOHEMAN 1862).
description: Published as part of Sekerka, Lukáš, 2016, Taxonomic and nomenclatural changes in Cassidinae (Coleoptera: Chrysomelidae), pp. 275-344 in Acta Entomologica Musei Nationalis Pragae 56 (1) on page 304, DOI: 10.5281/zenodo.5305725
Dyscolus salazarae Moret 2020, sp. nov.
Creators: name: Moret, Pierre
name: Murienne, Jérôme
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Carabidae
Dyscolus
Dyscolus salazarae

description: Dyscolus salazarae Moret sp. nov.
urn:lsid:zoobank.org:act: CD4CC653-FE0C-466A-A380-4C3361CB8579
Figs 32–33
Etymology
Noun in the genitive case, dedicated to Fernanda Salazar, administrator of the invertebrate collection of the QCAZ Museum (Pontificia Universidad Católica del Ecuador, Quito).
Type material
Holotype (only known specimen)
ECUADOR • ♂; Loja Province, Parque Nacional Podocarpus, Cajanuma, Waypoint 392; 4°6′58.4″ S, 79°10′18.6″ W; 2850 m a.s.l.; 17 Mar. 2015; P. Moret and C. Ruiz leg.; COI voucher PM392-09, BOLD sequence SUM059-18; MNHN.
Diagnostic description
Habitus: Fig. 32. Wingless. Body length: 9.3–9.6 mm. Head, pronotum and elytra brunneopiceous; legs, antennae and mouthparts reddish brown. Elytral microsculpture isodiametric. Head convex, markedly constricted basally, eyes small, not bulging, genae almost flat in dorsal view, as long as the eyes. Pronotum elongate, convex; sides weakly arcuate anterad, almost straight in basal fourth, with a very short sinuation at level of the basal seta, hind angles obtuse and blunt, anterior angles pronounced, broadly rounded; two pairs of lateral setae. Elytra elongate, subparallel; base relatively narrow, shoulders rounded; sides arcuate apically without subapical sinuation; striae entire, well impressed, not punctate; intervals slightly convex. Third elytral interval asetose. Legs rather short, meso- and metatarsomeres 1–3 with a lateral sulcus on each side; fourth metatarsomere with one pair of dorsolateral subapical setae, its apical lobes very short, the outer lobe twice as large as the inner lobe; fifth metatarsomere asetose ventrally. Last visible abdominal ventrite of the male with one pair of setae along its apical margin. Male genitalia: Fig. 33. Median lobe almost straight in its basal half, shortly arcuate before apex; apex slightly reflexed upward, narrow and acute in lateral view; endophallus without sclerotized structure. Female genitalia: unknown.
Comparisons
Closely related to D. moreti Perrault, 1993, but smaller (most specimens of D. moreti range from 10 to 11 mm), the lateral margin of the pronotum narrower, the elytra narrower and less convex, the apex of the aedeagus shorter, more acute, and not bent ventrally as in D. moreti.
Habitat
Upper montane forest on the Eastern slope of the Andes, at around 2850 m a.s.l.
Geographic distribution
Only known from the type locality in Southern Ecuador. Probably microendemic.
description: Published as part of Moret, Pierre & Murienne, Jérôme, 2020, Integrative taxonomy of the genus Dyscolus (Coleoptera, Carabidae, Platynini) in Ecuadorian Andes, pp. 1-55 in European Journal of Taxonomy 646 on pages 34-36, DOI: 10.5852/ejt.2020.646, http://zenodo.org/record/3829682
Additional file 6: of Community-based psychosocial interventions for people with schizophrenia in low and middle-income countries: systematic review and meta-analysis
Creators: name: Asher, Laura
name: Patel, Vikram
name: Silva, Mary J De
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Funnel plot for symptom severity. (PDF 65 kb)
title: A many-shells model for cell transmembrane potentials for pulsed electric field applications
Creators: name: Wong, Timothy
name: Timoshkin, Igor
name: MacGregor, Scott
name: Wilson, Mark
name: Given, Martin
name: Maclean, Michelle
Publisher: name: Strathprints - University of Strathclyde
Year: 2024

description: This article advances the existing theoretical analysis of pulsed electric field (PEF) treatment, an application of pulsed power technology. PEF treatment has attracted significant attention due to its potential to be used for non-thermal biological sterilization and inactivation of microorganisms, bio-extraction, and for the possible role that it may play in the treatment of tumors and cancers such as in electrochemotherapy. However, the bioelectric effects of impulsive electric fields on different biological matter are not yet completely understood. Further advances in this direction would aid in the optimization of the necessary pulse waveforms to achieve the desired PEF effects in, for example, various biomedical and food processing industries. In this work, the commonly used multishell model of microorganisms utilized for the analysis of cell transmembrane potentials (TMPs) has been generalized to include an arbitrary number of layers. This incorporates also a spheroidal geometry of arbitrary eccentricity. Analysis has been conducted on the novel mathematical model, which demonstrated the ability to estimate TMPs and relaxation times for an n -shell topology using a mesh-free approach. This allows for complex many-shelled cell models to be analyzed, free from the limitations of spatial or temporal discretization, that is, those present when using finite-element (FEM) or finite-volume-based methods. Using this model, the effects that the pulse rise time and pulse duration have on the developed TMPs in a single six-layer Saccharomyces cerevisiae , and under the microsecond-PEF regime, have been investigated. It has been found that the pulse rise time has a far lesser effect on the PEF action compared to the modulation of the pulse duration, supporting past experimental observations. The role of the electrical conductivity of the extracellular medium (and considering induced changes in the cell components) has additionally been studied, under low (σ = 1 mS/m), medium (σ = 50 mS/m), and high (σ = 100 mS/m) conductivity values. Estimations provided by this model may support the optimization of pulse waveforms for current and future PEF applications, and for the analysis of complex multilayered cell structures under pulsed electrical stress.
Additional file 1: of Lowering backward Raman and Brillouin scattering in waveguide Raman wavelength converters
Creators: name: Huy, Min Phan
name: Delaye, Philippe
name: Pauliat, Gilles
name: Dubreuil, Nicolas
name: Gérôme, Frédéric
name: Debord, Benoît
name: Benabid, Fetah
name: Lebrun, Sylvie
Publisher: name: Figshare
Year: 2017
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Raman and Brillouin parameters [36–42]. (DOC 489 kb)
Doryphoribius flavus Iharos 1966
Creators: name: Guil, Noemí
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Tardigrada
Eutardigrada
Parachela
Hypsibiidae
Doryphoribius
Doryphoribius flavus

description: Doryphoribius flavus (Iharos 1966)
Specimens present sculptured cuticle with polygonal areas over the dorsal body surface and the external side of the legs. On each leg, a gibbosity is present over the double-claws, which have smooth lunules at their base. Mean body size among the 79 specimens collected was 442 μm (SD 97), range 297 to 770 μm. The species has been cited for Europe, Asia, America and Africa. In the Iberian Peninsula, it has been recorded for Spain (McInnes 1994). This is the first time it is recorded for Madrid (Table 2). Doryphoribius flavus appeared in 19 of the sites sampled (Table 3) always in LF samples.
description: Published as part of Guil, Noemí, 2008, New records and within-species variability of Iberian tardigrades (Tardigrada), with comments on the species from the Echiniscus blumi-canadensis series, pp. 1-30 in Zootaxa 1757 on page 16, DOI: 10.5281/zenodo.181845
Additional file 6: of Community-based psychosocial interventions for people with schizophrenia in low and middle-income countries: systematic review and meta-analysis
Creators: name: Asher, Laura
name: Patel, Vikram
name: Silva, Mary J De
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Mental Health

description: Funnel plot for symptom severity. (PDF 65 kb)
Dyscolus piscator Moret 2020, sp. nov.
Creators: name: Moret, Pierre
name: Murienne, Jérôme
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Carabidae
Dyscolus
Dyscolus piscator

description: Dyscolus piscator Moret sp. nov.
urn:lsid:zoobank.org:act: C207DE54-A6E2-4C10-AF45-EDBE8BAF3D22
Figs 37, 40, 41 (below)
Etymology
Latin adjective meaning ‘fisherman’, in allusion to the feeding habits of this riparian species which preys on small water invertebrates.
Type material
Holotype
ECUADOR • ♂; Napo Province, Guamaní, Paso de la Virgen, Waypoint 283; 0°21′0.6″ S, 78°11′52.4″ W; 3890 m a.s.l.; 11 Mar. 2017; P. Moret and M. Gobbi leg.; QCAZ.
Paratypes (2 ♂♂, 1 ♀)
ECUADOR • 1 ♂; same collection data as for holotype; MNHN • 1 ♂; same collection data as for holotype; CPM • 1 ♀; same collection data as for holotype; COI voucher in ethanol PM283-01, BOLD sequence SUM239-18; CPM.
Diagnostic description
Habitus: Fig. 37. Wingless. Body length: 9.6–10.9 mm, bigger than D. placitus Moret sp. nov. Ventral surface paler, abdominal ventrites entirely reddish-testaceous. Elytral microsculpture slightly less transverse. Head bigger, genae slightly but distinctly convex in dorsal view (flat in D. placitus Moret sp. nov.); apex of the labrum bisinuate (straight in D. placitus Moret sp. nov.); mandibles much longer, finely acute at apex (length of the right mandible / width of the frons between the anterior setae = 0.95 in D. piscator Moret sp. nov., 1.21 in D. placitus Moret sp. nov.). Third elytral interval with 3–4 setae, fifth interval with 2–4 setae, seventh interval with 0–1 seta; 11–13 umbilicate setae along the lateral margin (17–20 in D. placitus Moret sp. nov.). Male genitalia: Fig. 40. Apex of the median lobe slightly curved, not strongly bent downwards as in D. placitus Moret sp. nov., with a rounded tip, not hooked as in D. placitus Moret sp. nov.
Habitat
Riparian in the upper montane forest with Polylepis, at around 3900 m a.s.l. Under stones at the edge of a small stream. This biotope is 50 m away from that of D. placitus Moret sp. nov.
Geographic distribution
Microendemic species, restricted to the Guamaní area in the Eastern Cordillera.
description: Published as part of Moret, Pierre & Murienne, Jérôme, 2020, Integrative taxonomy of the genus Dyscolus (Coleoptera, Carabidae, Platynini) in Ecuadorian Andes, pp. 1-55 in European Journal of Taxonomy 646 on pages 37-38, DOI: 10.5852/ejt.2020.646, http://zenodo.org/record/3829682
Eremobiotus alicatai Binda 1969
Creators: name: Guil, Noemí
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Tardigrada
Eutardigrada
Parachela
Hypsibiidae
Eremobiotus
Eremobiotus alicatai

description: Eremobiotus alicatai (Binda 1969)
The four specimens found for this species present dentate lunules in each double-claw and cuticle bars at the base of the inner double-claws in the first three pair of legs. Mean body size 512 μm (SD 75), range 440 to 616 μm. The species has been cited for Europe, Asia and Africa. It is the first time it is recorded for the Iberian Peninsula (Table 2). Eremobiotus alicatai only appeared at one sampling point (Table 3), in a LF sample.
description: Published as part of Guil, Noemí, 2008, New records and within-species variability of Iberian tardigrades (Tardigrada), with comments on the species from the Echiniscus blumi-canadensis series, pp. 1-30 in Zootaxa 1757 on page 16, DOI: 10.5281/zenodo.181845
Measuring information appetite
Creators: name: Hwang, Soo-Yeon
Publisher: name: No Publisher Supplied
Year: 2016

description: This dissertation stemmed from the question about when individuals are satisfied with information. It attempts to answer the question from the perspective of information appetite, i.e. the desire to spend time with information, expressed in the amount of time spent engaging in personal information practices (PIPs: consumption, dissemination, and creation of information for personal reasons).  Studied here are the American Time Use Survey (ATUS) dataset collected by the U.S. Bureau of Labor Statistics and a survey dataset collected on Amazon Mechanical Turk (MTurk). This dissertation presents analyses and a discussion of findings of the ATUS dataset, a description of the method of collecting the MTurk dataset, and analyses and a discussion of findings of the MTurk dataset.  Two propositions about information appetite (IA) were made, and both were supported by the datasets. The first proposition was that individuals have varying degrees of IA, as measured by the amount of time spent engaging in PIPs, which was supported by the ATUS and the MTurk data. The second proposition was that an individual has different IAs for different topical areas, which was supported by the MTurk data.  The study identified a small group of people who spent much time for PIPs, namely a high IA group. In addition to PIPs, the high IA group spent more time with their interested topics than the regular group did. As for what affects spending time for PIPs, having free time (e.g. not working/not having a job, or evenings and weekends) was found to be an important factor.   The dissertation ends with a discussion of implications, limitations and suggestions for future studies.
Selective progesterone receptor modulators for the treatment of dysmenorrhea: an update
Creators: name: Speciale, Anna Rosa
name: Ozpinar, Kubra
name: Giani, Milo
name: Tureli, Dilruba
name: Fambrini, Massimiliano
name: Vannuccini, Silvia
name: Petraglia, Felice
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy

description: Dysmenorrhea is a painful symptom associated with uterine contractions and menstrual bleeding and is treated by administering analgesic drugs. Since progesterone receptors (PRs) have a major role in regulating uterine tissues (myometrium and endometrium) physiology, oral contraceptives are used off-label for treating primary or secondary dysmenorrhea. The development of selective progesterone receptor modulators (SPRMs), a class of synthetic steroids with agonistic, antagonistic, or mixed effects in targeting PRs in different tissues, stimulated their possible clinical use for treating secondary dysmenorrhea related to uterine diseases (endometriosis, adenomyosis, uterine fibroids). The present review examines the development of the clinical trials and observational studies done with the different SPRMs for the treatment of dysmenorrhea in patients with uterine diseases. Mifepristone, telapristone acetate and vilaprisan have antagonistic activity on PRs, whereas ulipristal acetate and asoprisnil have both potent antagonist and partial agonist effects. Since no studies have been done on primary dysmenorrhea, the different SPRMs have been evaluated in the treatment of endometriosis, adenomyosis and uterine fibroid-related dysmenorrhea.
Spiritual soldiers and the politics of difference in the British Indian Army, 1900-1940
Creators: name: Imy, Kate Alison
Publisher: name: No Publisher Supplied
Year: 2016

description: In the first decades of the twentieth century, the British Indian Army went from being a force to suppress internal dissent and protect the borders of the subcontinent to a highly mobile army stationed around the globe. British needs for additional overseas forces meant combining three distinct regional armies of Bengal, Madras, and Bombay into a nominally united “Indian” Army. This single military force hid the recruiting biases and theories of martial difference that signaled the fracture, rather than the unity, of the army and the imperial project. This dissertation examines how the institutional changes of the British Indian Army enabled the social and cultural preconditions for the transition from colonial rule to a “globalized” post-colonial order.    The British Indian Army in the twentieth century prided itself on its central organization as an “Indian” Army, but the men who served as troops hailed from diverse regions of India as well as the modern nation states of Pakistan, Afghanistan, Nepal, and Bangladesh. The centrality of a nation-state ideal underpinning the “Indian” army not only figured into debates about anti-colonial nationalism, but in the increasing global mobility of both British and South Asian men. Britons and South Asians migrated to and worked in diverse imperial locales—from Australia to New Zealand, Singapore to Hong  Kong. Yet the differences between men were not only racial and regional. Significant class and caste disparities existed between the upwardly mobile cosmopolitan Indian officers and their low-ranking and uneducated enlisted counterparts. This encouraged further divisions between those able and willing to gain from a post-colonial Indian nation-state and those who would be left behind. Institutional biases also favored certain expressions of faith and devotion, racializing and militarizing the beliefs and practices of British Christians, Nepalese Gurkhas, and Punjabi Muslims and Sikhs.    The British Indian Army’s diversity and international fragmentation signaled that nation states struggled to keep pace with or claim a place for themselves in a new international order. “Globalization” served as an alternative but parallel model to empire. This story is about how diversity was managed—or failed to be managed—in a global and colonial army. The experience of imperial service further unspooled the controlled uniformity that imperial and military life demanded.
O'ZBEKISTONDA INSON KAPITALI VA MEHNAT BOZORINI RIVOJLANTIRISHDA YEVROPA TAJRIBASIDAN FOYDALANISH
Creators: name: Abduraxmonov, Azizbek
name: Yakubov, Ro'zmat
Publisher: name: Zenodo
Year: 2024

description: Inson resurs har bir tashkilot yoki korxonaning eng qadrli aktividir. Inson faqat qon va tanadan iborat emasligini va uning o‘ziga xos ruhiy dunyosiga ega ekanligini hisobga olsak, korxonada sodir bo‘ladigan har qanday hodisa uning ongiga ijobiy yoki salbiy ta’sir ko‘rsatishi va bu holat korxona ishirokidagi faoliyatga ta’sir qilishi amaliyotda isbotlangan hodisadir. Ba’zida tashkilotdagi ma’lum bir muammolarni hal qilishda faqatgina ruhlantirish faktori yetarli bo‘lmasligi mumkin. Ushbu maqolada korxonada inson resursidan optimal foydalanish uchun ba’zi xorij tashkiloti HR tizimi faoliyati tajribalari muhokama qilinadi. Motivatsiyani oshirishdan tashqari, xodimlarga ba’zi mas’uliyatlar berish, ularni konstruktiv tanqid va raqobat qilishlarini ta’minlash, ular o‘rtasida funksiyalarni adolatli taqsimlash kabi fikr mulohazalar ham ushbu maqolaning oldiga qo‘ygan maqsadidir.
Hypsibius camelopardis Ramazzotti & Maucci 1983
Creators: name: Guil, Noemí
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Tardigrada
Eutardigrada
Parachela
Hypsibiidae
Hypsibius
Hypsibius camelopardis

description: Hypsibius camelopardis Ramazzotti & Maucci 1983
The only specimen found has sculptured cuticle with irregular polygonal areas typical of this species. Body size of the specimen is 363 μm. The species has been cited only for Europe, and it is the first time to be recorded for Madrid Province (Table 2). In the Iberian Peninsula, it has been recorded for Spain (Maucci & Durante Pasa 1984) and Portugal (Ramazzotti & Maucci 1983). The only specimen appeared in a LF sample (Table 3).
description: Published as part of Guil, Noemí, 2008, New records and within-species variability of Iberian tardigrades (Tardigrada), with comments on the species from the Echiniscus blumi-canadensis series, pp. 1-30 in Zootaxa 1757 on page 16, DOI: 10.5281/zenodo.181845
Selective progesterone receptor modulators for the treatment of dysmenorrhea: an update
Creators: name: Ozpinar, Kubra
name: Speciale, Anna Rosa
name: Giani, Milo
name: Tureli, Dilruba
name: Fambrini, Massimiliano
name: Vannuccini, Silvia
name: Petraglia, Felice
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy

description: Dysmenorrhea is a painful symptom associated with uterine contractions and menstrual bleeding and is treated by administering analgesic drugs. Since progesterone receptors (PRs) have a major role in regulating uterine tissues (myometrium and endometrium) oral contraceptives are used off-label for treating primary or secondary dysmenorrhea. The development of selective progesterone receptor modulators (SPRMs) a class of synthetic steroids with agonistic, antagonistic, or mixed effects in targeting PRs in different tissues stimulated their possible clinical use for treating secondary dysmenorrhea related to uterine diseases (endometriosis, adenomyosis, uterine fibroids). The present review examines the development of the clinical trials and observational studies done with the different SPRMs for the treatment of dysmenorrhea in patients with uterine diseases. Mifepristone, telapristone acetate and vilaprisan have antagonistic activity on PRs, while ulipristal acetate and asoprisnil have both potent antagonist and partial agonist effects. While no studies have been done on primary dysmenorrhea, the different SPRMs have been studied in the treatment of endometriosis, adenomyosis and uterine fibroid-related dysmenorrhea.
Dyscolus arauzae Moret 2020, sp. nov.
Creators: name: Moret, Pierre
name: Murienne, Jérôme
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Carabidae
Dyscolus
Dyscolus arauzae

description: Dyscolus arauzae Moret sp. nov.
urn:lsid:zoobank.org:act: B992F8BA-69F8-4591-A010-440432759483
Figs 36, 39
Etymology
Noun in the genitive case, dedicated to María de los Ángeles Aráuz who took part in the discovery of this species.
Type material
Holotype
ECUADOR • ♂; Pichincha Province, Volcán Cayambe SW, Waypoint 73; 0.006962º N, 78.020278º W; 4405 m a.s.l.; 30 Oct. 2015; P. Moret and M. Aráuz leg.; QCAZ.
Paratypes (6 ♂♂, 6 ♀♀)
ECUADOR – Pichincha Province • 1 ♂; same collection data as for holotype; MNHN • 1 ♂, 1 ♀; same collection data as for holotype; CPM • 1 ♀; same collection data as for holotype; COI voucher PM073-03, BOLD sequence SUM020-18; CPM • 1 ♂; Volcán Cayambe SW, Waypoint 77; 0.007724º N, 78.023350º W; 4300 m a.s.l.; 30 Oct. 2015; P. Moret and M. Aráuz leg.; COI voucher PM077-01, BOLD sequence SUM099-18; CPM • 3 ♂♂, 2 ♀♀; Volcán Cayambe SW, Waypoint 267; 0°00.415′ N, 78°1.338′ W; 4294 m a.s.l.; 4 Mar. 2017; P. Moret and M. Gobbi leg.; CPM • 1 ♀ (in ethanol); Volcán Cayambe SW, Waypoint 76; 0.006860º N, 78.020714º W; 4390 m a.s.l.; 18 Jul. 2016; P. Moret and E. Moreno leg.; CPM • 1 ♀ (in ethanol); same collection data as for preceding; 4 Mar. 2017; P. Moret and M. Gobbi leg.; CPM.
Diagnostic description
Habitus: Fig. 36. Wingless. Body length: 8.5–10.9 mm. Antennae unicoloured, testaceous, as in D. hirsutus (apical part of the antennomeres darker in D. piscator Moret sp. nov. and D. placitus Moret sp. nov.). Colour of the ventral face variable. Dimensions of the head intermediate between D. piscator Moret sp. nov. and D. placitus Moret sp. nov. (length of the right mandible / width of the frons between the anterior setae = 1.05). Apex of the labrum straight. Lateroposterior seta of the pronotum close to the hind angle (slightly shifted forward in D. piscator Moret sp. nov. and D. placitus Moret sp. nov.). Third elytral interval with 4–7 setae, fifth interval with 2–4 setae, seventh interval normally without setae, only one paratype with one seta; 15–17 umbilicate setae along the lateral margin (11–13 in D. piscator Moret sp. nov., 17–20 in D. placitus Moret sp. nov.). Male genitalia: Fig. 39. Apex of the median lobe bent downwards, resembling that of D. placitus Moret sp. nov.; apical part of the endophallus covered with sclerotized squamae (unarmed in D. piscator Moret sp. nov. and D. placitus Moret sp. nov.).
Habitat
Riparian along glacier-fed streams in the humid superpáramo at 4300–4400 m a.s.l.
Geographic distribution
Microendemic species, presumably restricted to the Cayambe mountain.
description: Published as part of Moret, Pierre & Murienne, Jérôme, 2020, Integrative taxonomy of the genus Dyscolus (Coleoptera, Carabidae, Platynini) in Ecuadorian Andes, pp. 1-55 in European Journal of Taxonomy 646 on pages 38-40, DOI: 10.5852/ejt.2020.646, http://zenodo.org/record/3829682
Additional file 1: of Laboratory evaluation of the speed of kill of lotilaner (Credelioâ ˘) against Ixodes ricinus ticks on dogs
Creators: name: Murphy, Martin
name: Cavalleri, Daniela
name: Seewald, Wolfgang
name: Drake, Jason
name: Nanchen, Steve
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: French translation of the Abstract. (PDF 47.5 KB)
Dyscolus gobbii Moret 2020, sp. nov.
Creators: name: Moret, Pierre
name: Murienne, Jérôme
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Carabidae
Dyscolus
Dyscolus gobbii

description: Dyscolus gobbii Moret sp. nov.
urn:lsid:zoobank.org:act: 787DC50E-8874-4E7F-BCAD-FE33230508A1
Fig. 42
Etymology
Noun in the genitive case, dedicated to Mauro Gobbi, specialist of the ecology of glacier-foreland invertebrates, who took part in the discovery of this species.
Type material
Holotype
ECUADOR • ♀; Pichincha Province, Guamaní, Paso de la Virgen, Waypoint 210; 0°19′18.3″ S, 78°11′54.8″ W; 4230 m a.s.l.; 27 Feb. 2017; P. Moret and M. Gobbi leg.; COI voucher PM210-16, BOLD sequence SUM228 -18; QCAZ.
Paratype
ECUADOR • 1 ♀; Pichincha Province, Volcán Antisana NW, B1C3; 0.457780º S, 78.167970º W; 4401 m a.s.l.; 22 Apr. 2016; E. Moreno leg.; COI voucher in ethanol PM188-01, BOLD sequence SUM183-18; CPM.
Diagnostic description
Habitus: Fig. 42. Wingless. Body length: 10.2 mm (holotype) to 12.3 mm (paratype). Body piceous black, legs brownish with reddish-brown femora. Elytral microsculpture made of oblong sculpticells, shallowly impressed. Head big, convex dorsally; mandibles long and sharp, as long as the length of the head from base to apex of the labium; eyes moderately bulging, genae oblique, slightly convex in dorsal view. Pronotum transverse, subquadrate, narrower at base than at apex; lateroapical lobes broadly rounded; hind angles obtusely rounded; two pairs of lateral setae. Elytra oval-shaped, convex, with effaced humeri. Striae weakly impressed, with traces of punctuation; intervals 1–4 slightly convex, 5–8 flat; third interval with five or six discal setae. Last visible abdominal ventrite of the female with two pairs of setae along its apical margin. Legs slender but short; fourth metatarsomere with convex sides, without subapical dorsolateral setae (holotype) or with weak and short subapical dorsolateral setae (paratype), apical lobes ovoid, the outer lobe slightly longer than the inner lobe. Male genitalia: unknown. Female genitalia: unstudied.
Comparisons
This isolated species remotely resembles Dyscolus segnipes Moret, 1990, with which it coexists in the Guamaní páramo. Dyscolus segnipes has much shorter mandibles and well developed subapical dorsolateral setae on the fourth metatarsomere. The COI tree places gobbii and segnipes in two clades far apart from each other.
Habitat
Humid superpáramo, from 4200 to 4400 m a.s.l. The Guamaní specimen was collected under a stone on the shore of a small lake; the Antisana specimen was collected by pitfall trapping in a mesic environment, 20 metres from a glacier-fed stream.
Geographic distribution
Microendemic species, restricted to the Antisana and Guamaní areas in the Eastern Cordillera.
description: Published as part of Moret, Pierre & Murienne, Jérôme, 2020, Integrative taxonomy of the genus Dyscolus (Coleoptera, Carabidae, Platynini) in Ecuadorian Andes, pp. 1-55 in European Journal of Taxonomy 646 on pages 40-42, DOI: 10.5852/ejt.2020.646, http://zenodo.org/record/3829682
Additional file 1: Figures S1â  S5. of Widespread activation of antisense transcription of the host genome during herpes simplex virus 1 infection
Creators: name: Wyler, Emanuel
name: Menegatti, Jennifer
name: Franke, Vedran
name: Kocks, Christine
name: Boltengagen, Anastasiya
name: Hennig, Thomas
name: Theil, Kathrin
name: Rutkowski, Andrzej
name: Ferrai, Carmelo
name: Baer, Laura
name: Kermas, Lisa
name: Friedel, Caroline
name: Rajewsky, Nikolaus
name: Altuna Akalin
name: DĂślken, Lars
name: GrĂ¤Sser, Friedrich
name: Landthaler, Markus
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology
subject: Computational Biology

description: Figure S1 Coverage profiles of antisense transcripts. Figure S2 Validation of antisense transcripts. Figure S3 Antisense transcripts with PAA, knockout virus, and HSV-2 infection [67]. Figure S4 Antisense transcript promoters are already poised for transcription. Figure S5 Ectopically expressed BBC3as localizes outside the nucleus. (PDF 4275 kb)
title: Ligation LAMP Assay Targeting miRNA-155 Biomarker for Diagnosing Acute Myeloid Leukemia
Creators: name: Berdia, Jason
name: Buckmon, Logan
name: Vitievsky, Mark
name: Hebbar, Soma
Publisher: name: Digital Repository at the University of Maryland
Year: 2024
Subjects: subject: miR-155
subject: Ligation LAMP
subject: One Pot Assay
subject: Acute Myeloid Leukemia
subject: Biosensor
subject: Point of Care Diagnostics
subject: Fluorescent/Colorimetric LAMP
subject: First Year Innovation and Research Experience
subject: FIRE Molecular Diagnostics
subject: MSJ imaging

description: Ligation LAMP Assay Targeting miRNA-155 Biomarker for Diagnosing Acute Myeloid Leukemia Mark Vitievsky, Logan Buckmon, Soma Hebbar, Jason Berdia Acute Myeloid Leukemia (AML) is a severely dangerous form of blood cancer with high mortality rates, in part due to limitations in current diagnostic methods, which are invasive, expensive, and time-consuming. This study uses a ligation LAMP (loop-mediated isothermal amplification) assay as a possible new diagnostic tool which targets the overexpression of the miRNA-155 biomarker, which is known for its role in immune suppression in AML. The Ligation-LAMP assay offers a rapid, cost-effective, and minimally invasive alternative to the traditional methods of diagnosis, such as bone marrow biopsies or blood counts. This project evaluates the sensitivity and specificity of the Ligation LAMP assay using both fluorescent and colorimetric standards to detect varying concentrations of miRNA-155. Early findings show that higher levels of miRNA-155 correlate to faster fluorescence and colorimetric changes, in turn validating the assay’s potential for earlier AML detection. Future enhancements include the implementation of machine learning algorithms to hone in on the diagnostic thresholds, testing patient samples to address variability, and improving assay reliability. This project represents a step forward in the development of accessible and relatively inexpensive diagnostic tools for AML, providing the possibility of earlier diagnosis and improved patient livelihoods.
Hypsibius convergens Urbanowicz 1925
Creators: name: Guil, Noemí
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Tardigrada
Eutardigrada
Parachela
Hypsibiidae
Hypsibius
Hypsibius convergens

description: Hypsibius convergens (Urbanowicz 1925)
A total of 248 specimens were found in MR, LR, MT, LT and LF. Round, small septulum (following Guidetti & Bertolani (2001); since in Ramazzotti & Maucci (1983), they have doubts if there is a microplacoid or a septulum; however, in small specimens it was difficult to determine if it was a microplacoid or a septulum) was observed in specimens belonging to 20% of the samples where the species appeared. Some specimens had cuticle bars between the double-claws of the fourth pair of legs as in Bertolani (1982). Mean body size was 524 μm (SD 127), range 209 to 1111 μm. The species is considered cosmopolitan (McInnes 1994). In the Iberian Peninsula, in has been recorded for Spain (Rodríguez Roda 1952; Mihelčič 1954; Maucci & Durante Pasa 1984; Maucci 1991) and Portugal (Da Cunha 1941; Fontoura 1982; Maucci & Durante Pasa 1985). Hypsibius convergens was collected from 40 of our sampling points (Table 3).
description: Published as part of Guil, Noemí, 2008, New records and within-species variability of Iberian tardigrades (Tardigrada), with comments on the species from the Echiniscus blumi-canadensis series, pp. 1-30 in Zootaxa 1757 on page 16, DOI: 10.5281/zenodo.181845
A tool to reduce uncertainty in risk characterization
Creators: name: Hylton, Shavonne Nyoka
Publisher: name: No Publisher Supplied
Year: 2016

description: Risk assessors have utilized worst-case scenarios and the default assumption of 100% bioavailability to make ingestion exposure estimates. This leads to overestimation of risk by miscalculating the likelihood of a contaminant becoming bioavailable after exposure.  Furthermore, bioavailability studies often involve animal models, which are time consuming and expensive. As a result, in vitro gastrointestinal models have been incorporated into risk characterization for the calculation of bioaccessibility.  However, these models do not provide information on the effects of chemicals on the human body in the presence of low-level, chronic exposures, which are typical of environmental contaminants. The primary objectives of this research are two-fold: first, to examine how a cellular system is affected by heavy metal-contaminated soil after extraction by in vitro bioaccessibility techniques, and second to identify the utility of a hepatocellular model as a complementary tool for in vitro bioaccessibility models in risk assessment.   The percent bioaccessibility measured for five metals, Pb, As, Cd, Ni and Cr, across nine soils, using an in vitro system that incorporated synthetic saliva, gastric and intestinal fluids, varied from <10% to nearly 100% with the bioaccessibility of most metals declining from the saliva/gastric fluid to the intestinal fluid due to the higher pH of the latter. However, no single generalization predicted the association across all metals in the various soils, indicative of the need to evaluate multiple metals’ bioaccessibility when estimating risk from ingestion of soil. Subsequent to in vitro extraction, the toxicity of the bioaccessible fraction of nine soils was assessed using an in vitro hepatocellular model. A multiple regression linear model that predicts hepatotoxicity from bioaccessible metal concentration accounted for more than 80% of the variability in our predictive model, highlighting the potential of exposing an in vitro hepatocellar (or other cell type) model to the bioaccessible fluid fraction derived from soil as a complimentary and precursor screening tool for more expensive in vivo examinations. Conversely, Ni only accounted for 26%, Cr for 28%, Pb for 0.4%, Cd for 2% and As for 11% of the model variability on an individual basis if toxicity of all metals are independent of each other.  The use a human cellular system as a complimentary tool in risk assessment allows for the application of a mixed metal contaminant system as a more biologically relevant model than total metal content or metal bioaccessibility alone. Results from this study provided evidence of the utility of cellular model responses to bioaccessible fluids as a tool to evaluate contaminants since it examines mixture effects rather than single elements. Risk studies that evaluate exposure to mixtures of metals rather than individual metals better reflect real-world exposures to soils, which is of particular importance when assessing risk.
Additional file 1: Table S1. of The impact of N-acetylcysteine and ascorbic acid in contrast-induced nephropathy in critical care patients: an open-label randomized controlled study
Creators: name: Palli, Eleni
name: Demosthenes Makris
name: Papanikolaou, John
name: Garoufalis, Grigorios
name: Tsilioni, Irini
name: Zygoulis, Paris
name: Epaminondas Zakynthinos
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Mental Health

description: Classification of participants renal function according to RIFLE criteria at the entry study. Table S2. Medications with potential impact on renal function received by participants according to treatment group. Table S3. Univariate analysis of characteristics of survivors and non survivors. Table S4. CIN based on serum creatinine or cystatin-C changes or RIFLE score (between the day of radiocontrast material infusion and the day of CIN diagnosis). Table S5. Medications with potential impact on renal function received by participants according to the presence of CIN or not. Table S6. Fluid balance of patients included in the study according to the presence of CIN or not. (DOC 110 kb)
Agenysa stragula Sekerka 2016, comb. nov.
Creators: name: Sekerka, Lukáš
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Chrysomelidae
Agenysa
Agenysa stragula

description: Agenysa stragula (Boheman, 1862) comb. nov.
Mesomphalia stragula Boheman, 1862: 158 (original description).
Type locality. ‘Peruvia’.
Type material examined. HOLOTYPE: ♂, pinned, ‘ Peru [b, hw, s] || Type [w, p, s, c, rf] || Peru [hw] | Baly Coll. | 1905—54. [w, p, cb] || Mesomphalia | stragula | Boh | Peru [w, hw by Baly, cb] || Cuming | This species | was returned by | Boheman under | the name of | astulula Boh | is I believe | the type of | stragula | 34 [hw by Baly on underside of preceding label]’ (BMNH).
Remarks. Mesomphalia stragula was unknown to subsequent authors, only SPAETH (1914) transferred it to Pseudomesomphalia (= Stolas). Its holotype certainly belongs to Agenysa as it has a strongly widened last tarsomere. It is very similar to A. connectens as it has low convexity of elytra and reticulation nearly vanished on apical third of elytra but it differs in wider and trapezoidal pronotum with maximum width in apical third and more converging posterad than anterad while A. connectens has narrower and oval pronotum equally converging posterad and anterad. Agenysa stragula also has a black dorsum with dark metallic sheen and anterior part of explanate margin of elytra almost impunctate while A. connectens is bright metallic green or blue-green and has anterior part of the explanate margin finely but distinctly punctate. On the other hand, it is possible that A. stragula is only a local form of A. connectens but this requires further study based also on molecular data.
Distribution. Peru (BOHEMAN 1862).
description: Published as part of Sekerka, Lukáš, 2016, Taxonomic and nomenclatural changes in Cassidinae (Coleoptera: Chrysomelidae), pp. 275-344 in Acta Entomologica Musei Nationalis Pragae 56 (1) on page 305, DOI: 10.5281/zenodo.5305725