cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Nudge strategies to improve healthcare providers' implementation of evidence-based guidelines, policies and practices: A systematic review of trials included within Cochrane systematic reviews
Creators: name: Yoong, Serene
name: Hall, Alix
name: Stacey, Fiona
name: Grady, Alice
name: Sutherland, Rachel
name: Wyse, Rebecca
name: Anderson, Amy
name: Nathan, Nicole
name: Wolfenden, Luke
Publisher: name: Swinburne
Year: 2024

description: Background: Nudge interventions are those that seek to modify the social and physical environment to enhance capacity for subconscious behaviours that align with the intrinsic values of an individual, without actively restricting options. This study sought to describe the application and effects of nudge strategies on clinician implementation of health-related guidelines, policies and practices within studies included in relevant Cochrane systematic reviews. Methods: As there is varied terminology used to describe nudge, this study examined studies within relevant systematic reviews. A two-stage screening process was undertaken where, firstly, all systematic reviews published in the Cochrane Library between 2016 and 2018 were screened to identify reviews that included quantitative studies to improve implementation of guidelines among healthcare providers. Secondly, individual studies within relevant systematic reviews were included if they were (i) randomised controlled trials (RCTs), (ii) included a nudge strategy in at least one intervention arm, and (iii) explicitly aimed to improve clinician implementation behaviour. We categorised nudge strategies into priming, salience and affect, default, incentives, commitment and ego, and norms and messenger based on the Mindspace framework. Synthesis: The number and percentage of trials using each nudge strategy was calculated. Due to substantial heterogeneity, we did not undertake a meta-analysis. Instead, we calculated within-study point estimates and 95% confidence intervals, and used a vote-counting approach to explore effects. Results: Seven reviews including 42 trials reporting on 57 outcomes were included. The most common nudge strategy was priming (69%), then norms and messenger (40%). Of the 57 outcomes, 86% had an effect on clinician behaviour in the hypothesised direction, and 53% of those were statistically significant. For continuous outcomes, the median effect size was 0.39 (0.22, 0.45), while for dichotomous outcomes the median Odds Ratio was 1.62 (1.13, 2.76). Conclusions: This review of 42 RCTs included in Cochrane systematic reviews found that the impact of nudge strategies on clinician behaviour was at least comparable to other interventions targeting implementation of evidence-based guidelines. While uncertainty remains, the review provides justification for ongoing investigation of the evaluation and application of nudge interventions to support provider behaviour change. Trial registration: This review was not prospectively registered.
Additional file 2 of Evaluating a novel intervention in undergraduate medicine: an MBBS Curriculum Map
Creators: name: Wardle, Katie
name: Chakrabarti, Rima
name: Wright, Tor
name: Bennie, Taylor
name: Ntuiabane, Daniel
name: Gishen, Faye
Publisher: name: figshare
Year: 2024
Subjects: Biotechnology
Biological Sciences not elsewhere classified
Science Policy

description: Additional file 2. Focus group questions.
Additional file 2 of ATG4B and pS383/392-ATG4B serve as potential biomarkers and therapeutic targets of colorectal cancer
Creators: name: Hu, Wan-Hsiang
name: Liu, Ting-Ting
name: Liu, Pei-Feng
name: Morgan, Paul
name: Lin, I-Ling
name: Tsai, Wei-Lun
name: Cheng, Yi-Yun
name: Hsieh, Ang-Tsen
name: Hu, Tsung-Hui
name: Shu, Chih-Wen
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Supplementary Material 2
Supplementary document for Sub-bandgap photo-response of non-doped black silicon fabricated by femtosecond laser irradiation under water - 6964721.pdf
Creators: name: zhao, xiaona
name: Wang, Xuan
name: Du, WenHan
name: Lun, Yinghao
name: zhao, Bing
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: the detail of water processing facility and the comparison between passivation and unpassviation
Additional file 1 of ATG4B and pS383/392-ATG4B serve as potential biomarkers and therapeutic targets of colorectal cancer
Creators: name: Hu, Wan-Hsiang
name: Liu, Ting-Ting
name: Liu, Pei-Feng
name: Morgan, Paul
name: Lin, I-Ling
name: Tsai, Wei-Lun
name: Cheng, Yi-Yun
name: Hsieh, Ang-Tsen
name: Hu, Tsung-Hui
name: Shu, Chih-Wen
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Supplementary Material 1
Supplementary document for Sub-bandgap photo-response of non-doped black silicon fabricated by femtosecond laser irradiation under water - 6964721.pdf
Creators: name: zhao, xiaona
name: Wang, Xuan
name: Du, WenHan
name: Lun, Yinghao
name: zhao, Bing
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: the detail of water processing facility and the comparison between passivation and unpassviation
Supplementary document for Quantifying changes in oxygen saturation of the internal jugular vein in vivo using deep neuron networks and subject-specific three-dimensional Monte Carlo models - 6964755.pdf
Creators: name: Sun, Chin-Hsuan
name: Lee, Hao-Wei
name: Tasi, Ya-Hua
name: Luo, Jia-Rong
name: Sung, Kung-Bin
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement 1: detailed methods and results
title: Settingansatz‒Lebensweltansatz
Creators: name: Hartung, Susanne
name: Rosenbrock, Rolf
Publisher: name: Bundeszentrale für gesundheitliche Aufklärung (BZgA)
Year: 2022

description: Leitbegriffe der Gesundheitsförderung und Prävention. Glossar zu Konzepten, Strategien und Methoden
Additional file 1 of Adverse effects associated with acupuncture therapies: An evidence mapping from 535 systematic reviews
Creators: name: Xu, Meng
name: Yang, Chaoqun
name: Nian, Tao
name: Tian, Chen
name: Zhou, Liying
name: Wu, Yanan
name: Li, Yanfei
name: Deng, Xinxin
name: Li, Xiuxia
name: Yang, Kehu
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Science Policy

description: Additional file 1: Text S1: Search strategies. Text S2: The list of eligible studies. Table S1: Basic characteristics of the included studies. Table S2: Detailed evaluation of the methodological quality with AMSTAR-2.
Supplementary document for Quantifying changes in oxygen saturation of the internal jugular vein in vivo using deep neuron networks and subject-specific three-dimensional Monte Carlo models - 6964755.pdf
Creators: name: Sun, Chin-Hsuan
name: Lee, Hao-Wei
name: Tasi, Ya-Hua
name: Luo, Jia-Rong
name: Sung, Kung-Bin
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: Supplement 1: detailed methods and results
Supplementary document for Comparison of wavefront sensing and ablation imprinting for FEL focus diagnostics at FLASH2 - 6965123.pdf
Creators: name: Keitel, Barbara
name: Chalupsky, Jaromir
name: Jelinek, Simon
name: Burian, Tomas
name: Dziarzhytski, Siarhei
name: Hajkova, Vera
name: Juha, Libor
name: Kuglerová, Zuzana
name: Kuhlmann, Marion
name: Mann, Klaus
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement 1 text document
Supplementary_1 – Supplemental material for High dose PPI-amoxicillin dual therapy for the treatment of Helicobacter pylori infection: a systematic review with meta-analysis
Creators: name: Zhu, Yang-Jie
name: Zhang, Yi
name: Wang, Ting-Yi
name: Zhao, Jing-Tao
name: Zhao, Zhe
name: Zhu, Jian-Ru
name: Lan, Chun-Hui
Publisher: name: SAGE Journals
Year: 2020
Subjects: Nutrition and Dietetics not elsewhere classified
Oncology and Carcinogenesis not elsewhere classified
Pharmacology and Pharmaceutical Sciences not elsewhere classified

description: Supplemental material, Supplementary_1 for High dose PPI-amoxicillin dual therapy for the treatment of Helicobacter pylori infection: a systematic review with meta-analysis by Yang-Jie Zhu, Yi Zhang, Ting-Yi Wang, Jing-Tao Zhao, Zhe Zhao, Jian-Ru Zhu and Chun-Hui Lan in Therapeutic Advances in Gastroenterology
Additional file 1 of Evaluating a novel intervention in undergraduate medicine: an MBBS Curriculum Map
Creators: name: Wardle, Katie
name: Chakrabarti, Rima
name: Wright, Tor
name: Bennie, Taylor
name: Ntuiabane, Daniel
name: Gishen, Faye
Publisher: name: figshare
Year: 2024
Subjects: Biotechnology
Biological Sciences not elsewhere classified
Science Policy

description: Additional file 1. Primary survey questions.
Supplementary document for Intercomparison of flux, gradient, and variance-based optical turbulence (Cn²) parameterizations - 6965403.pdf
Creators: name: Pierzyna, Maximilian
name: Hartogensis, Oscar
name: Basu, Sukanta
name: Saathof, Rudolf
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement 1
Supplementary document for Heterojunction polarization enhancement and shielding for AlGaN-based solar-blind ultraviolet avalanche detectors - 6965453.pdf
Creators: name: wang, Bingxiang
name: Jiang, Ke
name: Zhang, Zi Hui
name: xie, zhiwei
name: Fang, Tong
name: Wang, Xianjun
name: Liu, Kexi
name: Chen, Yang
name: Liu, Mingrui
name: Jia, Yuping
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Modeling and simulation of negative polarization regime.
Supplementary document for Heterojunction polarization enhancement and shielding for AlGaN-based solar-blind ultraviolet avalanche detectors - 6965453.pdf
Creators: name: wang, Bingxiang
name: Jiang, Ke
name: Zhang, Zi Hui
name: xie, zhiwei
name: Fang, Tong
name: Wang, Xianjun
name: Liu, Kexi
name: Chen, Yang
name: Liu, Mingrui
name: Jia, Yuping
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: Modeling and simulation of negative polarization regime.
The Application of Sensor Technology to Improve Productivity and Welfare of Livestock
Creators: name: Almasi, Fazel
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 310114
subject: Systems biology
classificationCode: 300303
subject: Animal nutrition
classificationCode: 300304
subject: Animal protection (incl. pests and pathogens)

description: A thesis submitted in total fulfilment of the requirement for the degree of Doctor of Philosophy to the School of Applied Systems Biology, La Trobe University, Victoria, Australia.
Supplementary document for Intensity patterns of focused electromagnetic spherical wave with aberration - 6965898.pdf
Creators: name: Jeong, Tae Moon
name: Bulanov, Sergei
name: Shaisultanov, Rashid
name: Hadjisolomou, Prokopis
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supporting Equation steps
Additional file 3 of Evaluating a novel intervention in undergraduate medicine: an MBBS Curriculum Map
Creators: name: Wardle, Katie
name: Chakrabarti, Rima
name: Wright, Tor
name: Bennie, Taylor
name: Ntuiabane, Daniel
name: Gishen, Faye
Publisher: name: figshare
Year: 2024
Subjects: Biotechnology
Biological Sciences not elsewhere classified
Science Policy

description: Additional file 3. Coding framework.
Supplementary document for Intensity patterns of focused electromagnetic spherical wave with aberration - 6965898.pdf
Creators: name: Jeong, Tae Moon
name: Bulanov, Sergei
name: Shaisultanov, Rashid
name: Hadjisolomou, Prokopis
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: Supporting Equation steps
Supplementary document for Manipulation of large, irregular-shape particles using contour-tracking optical tweezers - 6966014.pdf
Creators: name: Omine, Ryohei
name: Masui, Shuzo
name: Kadoya, Shotaro
name: Michihata, Masaki
name: Takahashi, Satoru
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Optical Technology

description: Supplementary information
Ontology Based Semantic Data Management for Pandisciplinary Research Projects
Creators: name: Politze, Marius
name: Decker, Bernd
Publisher: name: Geographisches Institut der Universität zu Köln - Kölner Geographische Arbeiten
Year: 2016
Subjects: Data Management
Research Data

description: ProjektRepository, initially funded by the German Research Foundation, is a web based pandisciplinary repository for research projects that shall become a central component of scientific cooperation in scientific projects at the university. It is developed by IT Center of RWTH Aachen University on basis of Microsoft SharePoint as a widespread standard product for web based communication and collaboration. The product in turn is extended by several features concerning the tagging and formal retrieval of
data. These features make use of ontologies to define the structure of the repository.
description: Proceedings of the 2nd Data Management Workshop, 28.-29.11.2014, University of Cologne, Germany, Kölner Geographische Arbeiten, 96, pp. 63-68
Supplementary document for Nearly Polarization-Insensitive Angular Filters Enabled by Metal-Dielectric Photonic Crystal in the Visible Region - 6966093.pdf
Creators: name: Chen, Yihong
name: Lai, Jianjun
name: Xu, Tianyu
name: Lu, Bingyu
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: surface rouhness map
Additional file 1 of Neurophysiological assessment of cortical activity in DEPDC5- and NPRL3-related epileptic mTORopathies
Creators: name: Mabika, Madora
name: Agbogba, Kristian
name: Côté, Samantha
name: Lippé, Sarah
name: Riou, Émilie
name: Cieuta, Cécile
name: Lepage, Jean-François
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Developmental Biology
subject: Mental Health

description: Additional file 1. Supplementary figure 1. Tissue-content normalization formula for GABA and glutamate quantification. Supplementary figure 2. Defined regions of interest for EEG data analyses. Supplementary figure 3. Curves of cortical excitability. Supplementary figure 4. Average cortical silent period in each group. Supplementary figure 5. Group-average changes in frequencies’ ITC during the Chirp onset. Supplementary figure 6. Group-average changes in frequencies’ ERSP in response to the chirp sound. Supplementary figure 7. Group-average changes in frequencies’ ITC in response to the chirp sound.
Supplementary document for Nearly Polarization-Insensitive Angular Filters Enabled by Metal-Dielectric Photonic Crystal in the Visible Region - 6966093.pdf
Creators: name: Chen, Yihong
name: Lai, Jianjun
name: Xu, Tianyu
name: Lu, Bingyu
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: surface rouhness map
Additional file 2 of Risk factors of pneumonia in persons with and without Alzheimer’s disease: a matched cohort study
Creators: name: Järvinen, Heli
name: Tolppanen, Anna-Maija
name: Hartikainen, Sirpa
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Mental Health
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 2: Supplementary Table 2. Reasons for censoring in both cohorts.
Patrones de interacción seleccionados con base en el dominio y el objetivo principal de la aplicación. Etapa 1.
Creators: name: Delgado Guerrero, Jonathan
name: Antonelli, Leandro
name: Firmenich, Diego Andrés
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 461206
subject: Software architecture

description: La presenta tabla brinda detalles de los patrones de interacción seleccionados con base en el dominio y el objetivo principal de la aplicación: "Actualización de datos de los usuarios con validación biométrica (reconocimiento facial)", como parte de la Etapa 1 del método propuesto en el presente artículo.
Supplementary document for Highly integrated automatic injection terahertz microfluidic biosensor based on metasurface and LT-GaAs photoconductive antenna - 6966446.pdf
Creators: name: Meng, Qinghao
name: Zhao, Yuhan
name: Wang, Xueyan
name: Su, Bo
name: Zhang, Shengbo
name: Cui, Hailin
name: Zhang, Cunlin
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental Document
Supplementary document for Highly integrated automatic injection terahertz microfluidic biosensor based on metasurface and LT-GaAs photoconductive antenna - 6966446.pdf
Creators: name: Meng, Qinghao
name: Zhao, Yuhan
name: Wang, Xueyan
name: Su, Bo
name: Zhang, Shengbo
name: Cui, Hailin
name: Zhang, Cunlin
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: Supplemental Document
Additional file 1 of A simple-to-use nomogram for predicting prolonged mechanical ventilation for children after Ebstein anomaly corrective surgery: a retrospective cohort study
Creators: name: Liu, Qiao
name: Luo, Qipeng
name: Li, Yinan
name: Wu, Xie
name: Wang, Hongbai
name: Huang, Jiangshan
name: Jia, Yuan
name: Yuan, Su
name: Yan, Fuxia
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Science Policy

description: Additional file 1. STROBE Statement (checklist of items that should be included in reports of observational studies).
Additional file 1 of Long-term exposure to ambient ozone at workplace is positively and non-linearly associated with incident hypertension and blood pressure: longitudinal evidence from the Beijing-Tianjin-Hebei medical examination cohort
Creators: name: Hu, Songhua
name: Xu, Ximing
name: Li, Chunjun
name: Zhang, Li
name: Xing, Xiaolong
name: He, Jiangshan
name: Guo, Pei
name: Zhang, Jingbo
name: Niu, Yujie
name: Chen, Shuo
name: Zhang, Rong
name: Liu, Feng
name: Ma, Shitao
name: Zhang, Mianzhi
name: Guo, Fenghua
name: Zhang, Minying
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Supplementary Material 1
Supplementary document for Aluminum scandium nitride on 8-inch Si wafers: Material characterization and photonic device demonstration - 6966869.pdf
Creators: name: Xiong, Zixin
name: Zhang, Xiangchao
name: Li, Zhenyu
name: Liu, Xiaofei
name: qiu, yang
name: Zhao, Xingyan
name: Zheng, Shaonan
name: Zhong, Qize
name: Dong, Yuan
name: Hu, Ting
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: The Supplementary Materials are shown in Fig. S1-S7
Supplementary document for Aluminum scandium nitride on 8-inch Si wafers: Material characterization and photonic device demonstration - 6966869.pdf
Creators: name: Xiong, Zixin
name: Zhang, Xiangchao
name: Li, Zhenyu
name: Liu, Xiaofei
name: qiu, yang
name: Zhao, Xingyan
name: Zheng, Shaonan
name: Zhong, Qize
name: Dong, Yuan
name: Hu, Ting
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: The Supplementary Materials are shown in Fig. S1-S7
Supplementary document for Long-distance and high-precision ranging with dual-comb nonlinear asynchronous optical sampling - 6967995.pdf
Creators: name: Meng, Yun
name: Shi, Yanqing
name: Zou, Kai
name: Song, Youjian
name: Hu, Xiaolong
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: This document includes more experimental details.
Additional file 1 of The association of genetic variation in CACNA1C with resting-state functional connectivity in youth bipolar disorder
Creators: name: Jiang, Xinyue
name: Sultan, Alysha A.
name: Dimick, Mikaela K.
name: Zai, Clement C.
name: Kennedy, James L.
name: MacIntosh, Bradley J.
name: Goldstein, Benjamin I.
Publisher: name: figshare
Year: 2024
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: Additional file 1. Supplementary Materials.
Supplementary document for Long-distance and high-precision ranging with dual-comb nonlinear asynchronous optical sampling - 6967995.pdf
Creators: name: Meng, Yun
name: Shi, Yanqing
name: Zou, Kai
name: Song, Youjian
name: Hu, Xiaolong
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: This document includes more experimental details.
Supplementary document for Highly Intrinsic Carrier Mobility in Tin Diselenide Crystal Accessed with Ultrafast Terahertz Spectroscopy - 6968226.pdf
Creators: name: Ma, Guo-Hong
name: Sun, Kaiwen
name: Xia, Wei
name: Wang, Chen
name: Suo, Peng
name: Zou, Yuqing
name: Peng, Jun
name: Wang, Wei
name: Lin, Xian
name: Jin, Zuanming
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Estimation of Pump Fluence and carrier density, supplemental TDS spectrum, contribution of Drude term and Lorentz term under various pump fluence, details in the Drude-Smith fitting and Drude-Lorentz-Smith fitting
Supplementary document for Highly Intrinsic Carrier Mobility in Tin Diselenide Crystal Accessed with Ultrafast Terahertz Spectroscopy - 6968226.pdf
Creators: name: Ma, Guo-Hong
name: Sun, Kaiwen
name: Xia, Wei
name: Wang, Chen
name: Suo, Peng
name: Zou, Yuqing
name: Peng, Jun
name: Wang, Wei
name: Lin, Xian
name: Jin, Zuanming
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: Estimation of Pump Fluence and carrier density, supplemental TDS spectrum, contribution of Drude term and Lorentz term under various pump fluence, details in the Drude-Smith fitting and Drude-Lorentz-Smith fitting
Supplementary document for Evaluation and correction of laser scattering-based particle size measurements at high obscurations using the Monte Carlo method - 6968344.pdf
Creators: name: Su, Geyi
name: Sun, Cunjin
name: Zhang, Shiwei
name: Fan, Fengxian
name: Su, Mingxu
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: The detailed descriptions of the Monte Carlo method.
Supplementary document for Evaluation and correction of laser scattering-based particle size measurements at high obscurations using the Monte Carlo method - 6968344.pdf
Creators: name: Su, Geyi
name: Sun, Cunjin
name: Zhang, Shiwei
name: Fan, Fengxian
name: Su, Mingxu
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: The detailed descriptions of the Monte Carlo method.
Improving the effectiveness of oncolytic virotherapy: insights from mathematical modelling
Creators: name: Morselli, David
Publisher: name: Swinburne
Year: 2024

description: Oncolytic viruses are viral particles that specifically infect cancer cells, while mostly preserving healthy tissues. Their use as cancer treatment has received considerable attention in recent years, but their clinical use still faces many challenges. Some of the main obstacles to the propagation of oncolytic viruses inside a tumour include clearance by the immune system, physical obstacles and inhibition of the infection in areas with low oxygen supply. All these dynamics are still poorly understood.The main aim of this thesis is to develop mathematical models to study spatial dynamics of infections by oncolytic viruses and obstacles to its diffusion.
Additional file 1 of Longitudinal neurobehavioral profiles in children and young adults with PTEN hamartoma tumor syndrome and reliable methods for assessing neurobehavioral change
Creators: name: Busch, Robyn M.
name: Frazier II, Thomas W.
name: Sonneborn, Claire
name: Hogue, Olivia
name: Klaas, Patricia
name: Srivastava, Siddharth
name: Hardan, Antonio Y.
name: Martinez-Agosto, Julian A.
name: Sahin, Mustafa
name: Eng, Charis
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1.
Supplementary document for Demonstration of Photonics-based D-band Integrated Localization and Communication - 6968431.pdf
Creators: name: Wang, Qigejian
name: Deng, Yirui
name: Mishra, Deepak
name: Xie, Yixuan
name: Aboutanios, Elias
name: Atakaramians, Shaghik
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: supplementary file
Supplementary document for Demonstration of Photonics-based D-band Integrated Localization and Communication - 6968431.pdf
Creators: name: Wang, Qigejian
name: Deng, Yirui
name: Mishra, Deepak
name: Xie, Yixuan
name: Aboutanios, Elias
name: Atakaramians, Shaghik
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: supplementary file
Supplementary document for Surface-normal illuminated pseudo-planar Ge-on-Si avalanche photodiodes with high gain and low noise - 6968441.pdf
Creators: name: Yi, Xin
name: Fleming, Fiona
name: Mirza, Muhammed
name: Jin, Xiao
name: KIRDODA, JAROSŁAW
name: Dumas, Derek
name: Saalbach, Lisa
name: Muir, Dave
name: Mrudul, Modal
name: Smith, Charlie
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Device fab and characterisation method
How to Manage Data Management? Challenges Facing New Projects and How to Address Them
Creators: name: Recker, Jonas
name: Katsanidou, Alexia
Publisher: name: Geographisches Institut der Universität zu Köln - Kölner Geographische Arbeiten
Year: 2016
Subjects: Data Management
Research Data

description: The requirements of research data management (RDM) and data sharing can seem quite overwhelming for researchers and principle investigators, particularly if they come up relatively late in a project. However, as this article hopes to demonstrate, if considered early on in the research and addressed consistently throughout, data anagement is a manageable effort. In fact, many researchers will find that what nowadays we call ‘research data management’ – understood as the entirety of practices and procedures employed to protect, validate, and describe data with the ultimate objective of keeping them accessible and understandable – actually has a considerable overlap with the standard, day-to-day research practices they have been employing all along. And while planning and implementing research data management certainly involves a somewhat greater effort initially, this investment will pay off later in the project in the form of higher-quality data and efficient use of available resources. Exploring the what, why, when, and how of data management, this article seeks to de-mystify RDM procedures and encourages researchers to reach out to existing support services for help.
description: Proceedings of the 2nd Data Management Workshop, 28.-29.11.2014, University of Cologne, Germany, Kölner Geographische Arbeiten, 96, pp. 69-76
Supplementary document for Surface-normal illuminated pseudo-planar Ge-on-Si avalanche photodiodes with high gain and low noise - 6968441.pdf
Creators: name: Yi, Xin
name: Fleming, Fiona
name: Mirza, Muhammed
name: Jin, Xiao
name: KIRDODA, JAROSŁAW
name: Dumas, Derek
name: Saalbach, Lisa
name: Muir, Dave
name: Mrudul, Modal
name: Smith, Charlie
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: Device fab and characterisation method
The DFG Perspective: Research Data Management with a Focus on Collaborative Research Centres (SFB)
Creators: name: Redöhl, Brit
Publisher: name: Geographisches Institut der Universität zu Köln - Kölner Geographische Arbeiten
Year: 2016
Subjects: Data Management
German Research Foundation
Collaborative Research Centre
Research Data

description: The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) is the largest organisation providing third-party research funding in Germany. As such, the DFG is well aware of the  ncreasing importance of Research Data Management in all fields of research. Accordingly, the DFG supports the establishment of suitable community-specific guidelines or minimum standards for the handling of research data and the identification of potential for re-use. At institutional level this led to the enactment of DFG Guidelines on the handling of research data in autumn 2015. At the level of funding programmes there is first and foremost the open funding programme 'Information Infrastructures for Research Data'. Furthermore, DFG is raising awareness of projects focussing on information infrastructure (INF) embedded in Collaborative Research Centres (SFB). Here, new procedures and a highlighted emphasis
during the peer review process are being introduced.
description: Proceedings of the 2nd Data Management Workshop, 28.-29.11.2014, University of Cologne, Germany, Kölner Geographische Arbeiten, 96, pp. 77-81
Supplementary document for Optofluidic SERS based on Ag nanocubes with high sensitivity for detecting prevalent water pollutant - 6968469.pdf
Creators: name: Ran, Na
name: Wang, Xing
name: Gan, Yuan
name: Zhang, Jie
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Detailed experimental and simulation sections
Supplementary document for Optofluidic SERS based on Ag nanocubes with high sensitivity for detecting prevalent water pollutant - 6968469.pdf
Creators: name: Ran, Na
name: Wang, Xing
name: Gan, Yuan
name: Zhang, Jie
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: Detailed experimental and simulation sections
Supplementary document for Robust detection of rotational Doppler shift with randomly fluctuated light - 6968559.pdf
Creators: name: Zhao, Xuechun
name: Lu, Xingyuan
name: Hu, Zhiquan
name: Liu, Tong
name: Hang, Yiyi
name: Gao, Jianbo
name: Wang, Zhuoyi
name: Zhan, Qiwen
name: Cai, Yangjian
name: ren, yuan
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Experimental setup and method
Laser-enzyme dual responsive liposomes to regulate autophagy in synergy with phototherapy for melanoma treatment
Creators: name: Sui, Mingli
name: Wang, Chaoqun
name: Tian, Yingmei
name: Zhang, Huijuan
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Phototherapy can cause autophagy while killing tumour cells, leading to tumour recurrence and metastasis. Here, we constructed a laser and enzyme dual responsive nanodrug delivery system Tf-Te@CTSL-HCQ (TT@CH) to precisely regulate autophagy in synergy with phototherapy to inhibit the proliferation and metastasis of melanoma. Firstly, transferrin (Tf) was used as a nanoreactor to synthesise phototherapy agent Tf-Te by the biological template mineralisation method. Then, the thermosensitive liposome modified with FAP-α-responsive peptide (CAP) was used as a carrier to encapsulate autophagy inhibitor hydroxychloroquine (HCQ) and Tf-Te, to obtain an intelligent TT@CH delivery system. Once arriving at the tumour site, TT@CH can be cleaved by FAP-α overexpressed on cancer-associated fibroblasts (CAFs), and release Tf-Te and HCQ. Then Tf-Te can target melanoma cells and exert PTT/PDT anti-tumour effect. What’s more, hyperpyrexia induced by PTT can further promote drugs release from TT@CH. Meanwhile, HCQ simultaneously inhibited autophagy of CAFs and melanoma cells, and down-regulated IL-6 and HMGB1 secretion, thus effectively inhibiting melanoma metastasis. Pharmacodynamic results exhibited the best anti-tumour effect of TT@CH with the highest tumour inhibition rate of 91.3%. Meanwhile, lung metastatic nodules of TT@CH treated mice reduced by 124.33 compared with that of mice in control group. Overall, TT@CH provided an effective therapy strategy for melanoma.
Supplementary document for Robust detection of rotational Doppler shift with randomly fluctuated light - 6968559.pdf
Creators: name: Zhao, Xuechun
name: Lu, Xingyuan
name: Hu, Zhiquan
name: Liu, Tong
name: Hang, Yiyi
name: Gao, Jianbo
name: Wang, Zhuoyi
name: Zhan, Qiwen
name: Cai, Yangjian
name: ren, yuan
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: Experimental setup and method
Antibody-drug conjugates targeting DDR1 as a novel strategy for treatment of breast cancer
Creators: name: Tao, Yiran
name: Lu, Ying
name: Xue, Ting
name: Lai, Qinhuai
name: Song, Hengrui
name: Chen, Xiaofeng
name: Guo, Cuiyu
name: Yang, Jinliang
name: Wang, Yuxi
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Astronomical and Space Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: Antibody-drug conjugates (ADCs) have emerged as a novel class of targeted cancer therapies and been successfully applied in the treatment of breast cancer (BC). Discoidin domain receptor 1 (DDR1) is a single transmembrane receptor tyrosine kinase and has been identified as a possible target for cancer. In this study, we explored the potential of an anti-DDR1 ADC, named T4H11-DM4, for the treatment of DDR1-positive BC. We demonstrated that high protein expression and RNA expression of DDR1 in BC tissues. In vitro, T4H11-DM4 was potently cytotoxic to DDR1-expressing BC cells, with IC50 in the nanomolar range. In mice BC xenograft models, T4H11-DM4 dramatically eliminated BC tumours, without observable toxicity. Taken together, our findings demonstrated that DDR1 can serve as a promising therapeutic target for BC.
Long-term residence and efficacy of adenovirus-mimetic nanoparticles in renal target tissue
Creators: name: Walter, Melanie
name: Weißbach, Hannah
name: Gembardt, Florian
name: Halder, Sagor
name: Schorr, Kathrin
name: Fleischmann, Daniel
name: Todorov, Vladimir
name: Hugo, Christian
name: Goepferich, Achim
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer

description: A major shortcoming in the treatment of mesangial cell-associated diseases such as IgA nephropathy, diabetic nephropathy, or lupus nephritis, which frequently progress to end-stage renal disease, is poor drug availability in the glomerular mesangium. Drug delivery via active targeting of nanoparticles, using ligands attached to the particle surface for target cell recognition to increase the biodistribution to the mesangium, is a promising strategy to overcome this hurdle. However, although several glomerular tissue targeting approaches have been described, so far no study has demonstrated the particles’ ability to deliver sufficient drug amounts combined with an appropriate nanoparticle target retention time to trigger relevant biological effects in the mesangium. In our study, we encapsulated erastin, a ferroptosis-inducing model compound, into adenovirus-mimetic, mesangial cell-targeting nanoparticles, enabling the direct visualisation of biological effects through ferroptosis-dependent histological changes. By intravital microscopy and analysis of histological sections, we were not only able to localise the injected particles over 10 days within the target cells but also to demonstrate biological activity in the renal glomeruli. In conclusion, we have characterised adenovirus-mimetic nanoparticles as a highly suitable drug delivery platform for the treatment of mesangial cell-associated diseases and additionally provided the basis for a potential renal disease model.
Additional file 1 of A scoping review of equity-focused implementation theories, models and frameworks in healthcare and their application in addressing ethnicity-related health inequities
Creators: name: Gustafson, Papillon
name: Abdul Aziz, Yasmin
name: Lambert, Michelle
name: Bartholomew, Karen
name: Rankin, Nicole
name: Fusheini, Adam
name: Brown, Rachel
name: Carswell, Peter
name: Ratima, Mihi
name: Priest, Patricia
name: Crengle, Sue
Publisher: name: figshare
Year: 2023
Subjects: Space Science
Medicine
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Cancer
Science Policy

description: Additional file 1. Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) Checklist
Supplementary document for Fabry-Pérot laser diode spectrum switching by controllable self-injection locking to high-quality-factor optical microresonator - 6968836.pdf
Creators: name: Galkin, Maxim
name: Chermoshentsev, Dmitry
name: Pavlov, Vladislav
name: Shitikov, Artem
name: Lonshakov, Evgeny
name: Lobanov, Valery
name: Bilenko, Igor
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Revised supplemental document
Evaluation of mRNA lipoplexes prepared using modified ethanol injection method as a tumour vaccine
Creators: name: Hattori, Yoshiyuki
name: Tang, Min
name: Sato, Junnosuke
name: Tsuiji, Makoto
name: Kawano, Kumi
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: We have previously demonstrated that messenger RNA (mRNA) lipoplexes composed of N-hexadecyl-N,N-dimethylhexadecan-1-aminium bromide (DC-1-16), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), and polyethylene glycol-cholesteryl ether (PEG-Chol) exhibited high protein expression in the lungs and spleen of mice after intravenous injection and induced high levels of antigen-specific IgG1 upon immunisation. In this study, we optimised PEG modification in mRNA lipoplexes to reduce mRNA accumulation in the lungs and evaluated the suppression of tumour growth in mice bearing mouse lymphoma E.G7-ovalbumin (OVA) tumours by immunising them with an intravenous injection of OVA mRNA lipoplexes. PEGylation of mRNA lipoplexes with 3 mol% PEG-Chol (LP-DC-1-16-3PCL) prevented agglutination of erythrocytes and reduced accumulation in the lungs. Intravenous injection of LP-DC-1-16-3PCL lipoplexes containing OVA mRNA into mice induced high levels of anti-OVA IgG1 (83,000 mU/mL) in serum, and exhibited a high cytotoxic activity (97%) against E.G7-OVA cells by the splenocytes of mice. Furthermore, immunisation with LP-DC-1-16-3PCL lipoplexes containing OVA mRNA suppressed E.G7-OVA tumour growth compared to control mRNA. Based on these results, LP-DC-1-16-3PCL lipoplexes may be an effective mRNA vaccine for inducing antibody- and cytotoxic cell-mediated immune responses to tumours through intravenous injection.
Supplementary document for Enhancement of silicon vacancy fluorescence intensity in SiC using dielectric cavity - 6969629.pdf
Creators: name: Hu, Qi-Cheng
name: Xu, Ji
name: Luo, Qin-Yue
name: Hu, Hai-Bo
name: Guo, Pei-Jie
name: Liu, Cheng-Ying
name: Zhao, Shuang
name: Zhou, Yu
name: Wang, Junfeng
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Technical details, Instrument details, Detailed simulation, Enhancement varying with the laser power
МОДЕЛЬ МИРА В РАССКАЗЕ Л.ПЕТРУШЕВСКОЙ "ШОПЕН И МЕНДЕЛЬСОН''.
Creators: name: Закирова, Дилрабо
name: Абдурахмонова, Хуршида
Publisher: name: Zenodo
Year: 2024

description: В данной  статье говорится о произведении написанное  в жанре рассказа с элементами сатиры, повествуещее о жизни героев на протяжении короткого времени. Этот рассказ о взаимоотношениях людей в современном мегаполисе, о непонимании друг друга, о равнодушии и невежестве, отсутствии духовности в людях, ярким представителем которых является молодая женщина – «брошка», соседка стариков, конфликт  в котором развивается между двумя мирами: миром пошлости и миром возвышенных чувств.
Additional file 1 of Decoding the immune landscape following hip fracture in elderly patients: unveiling temporal dynamics through single-cell RNA sequencing
Creators: name: Lu, Yining
name: Luo, Yang
name: Zhang, Qi
name: Chen, Wei
name: Zhang, Ning
name: Wang, Ling
name: Zhang, Yingze
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Mental Health
subject: Hematology

description: Supplementary Material 1
Long-term hospital resource utilization and associated costs of care for patients initiating nivolumab in advanced non-small cell lung cancer in France
Creators: name: Grumberg, Valentine
name: Chouaïd, Christos
name: Cotté, François-Emery
name: Jouaneton, Baptiste
name: Jolivel, Ronan
name: Gaudin, Anne-Françoise
name: Reynaud, Dorothée
name: Assié, Jean-Baptiste
name: Borget, Isabelle
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: In advanced cancers, healthcare resource utilization (HCRU) and costs usually increase until death. However, few studies have measured HCRU over time in patients treated with immunotherapies. The objective was to describe the evolution of HCRU and costs over four years for patients with advanced non-small cell lung cancer (aNSCLC) initiating nivolumab. Based on the French hospital reimbursement database, all aNSCLC patients initiating nivolumab in the 2nd line or later in 2015 or 2016 were followed until 2019. HCRU (including hospitalizations and hospital visits) and costs (payer perspective) were described annually after nivolumab initiation. Trends in HCRU were analyzed with the Mann-Kendall test. As most patients did not reach the four-year follow-up, cost-analysis was performed without adjustment throughout, without adjustment in uncensored cases only or with adjustment using for all patients using the Bang&Tsiatis method. 10,452 patients initiating nivolumab were evaluated. The percentage of patients hospitalized or with hospital visits decreased (p p p per capita costs also decreased. The method without adjustment provided the lowest cost over time (€44,404 (Y1), €32,206 (Y2); €28,552 (Y3); €18,841(Y4)) while the Bang&Tsiatis method presented the highest cost (€45,002 (Y1), €36,330 (Y2); €35,080 (Y3); €28,931 (Y4)). HCRU and costs for NSCLC patients treated with nivolumab decreased over time. Cost estimates are dependent on the statistical method used to take into account uncertainty, but costs decreased over time whatever the method used.
Supplementary document for ATN-Res2Unet: An advanced deep learning network for the elimination of saturation artifacts in endoscopy optical coherence tomography - 6969829.pdf
Creators: name: Zhao, Yongfu
name: Kong, Ruiming
name: Ma, Fei
name: qi, sumin
name: Dai, Cuixia
name: Meng, Jing
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Additional text, tables, and figures.
Long-term hospital resource utilization and associated costs of care for patients initiating nivolumab in advanced non-small cell lung cancer in FranceDeclarations of financial/other interest
Creators: name: Grumberg, Valentine
name: Chouaïd, Christos
name: Cotté, François-Emery
name: Jouaneton, Baptiste
name: Jolivel, Ronan
name: Gaudin, Anne-Françoise
name: Reynaud, Dorothée
name: Assié, Jean-Baptiste
name: Borget, Isabelle
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Objectives In advanced cancers, healthcare resource utilization (HCRU) and costs usually increase until death. However, few studies have measured HCRU over time in patients treated by immunotherapies. The objective was to describe the evolution of HCRU and costs over four years for patients with advanced non-small cell lung cancer (aNSCLC) initiating nivolumab. Materials and Methods Based on the French hospital reimbursement database, all aNSCLC patients initiating nivolumab in 2nd line or later in 2015 or 2016 were followed until 2019. HCRU (including hospitalizations and hospital visits) and costs (payer perspective) were described annually after nivolumab initiation. Trends in HCRU were analyzed with the Mann-Kendall test. As most patients did not reach the four-year follow-up, cost-analysis was performed without adjustment throughout, without adjustment in uncensored cases only or with adjustment using for all patients using the Bang&Tsiatis method. Results 10,452 patients initiating nivolumab were evaluated. The percentage of patients hospitalized or with hospital visit decreased (p per capita costs also decreased. The method without adjustment provided the lowest cost over time (€44,404 (Y1), €32,206 (Y2); €28,552 (Y3); €18,841(Y4)) while the Bang&Tsiatis method presented the highest cost (€45,002 (Y1), €36,330 (Y2); €35,080 (Y3); €28,931 (Y4)). Conclusion HCRU and costs for NSCLC patients treated by nivolumab decreased over time. Cost estimates are dependent on the statistical method used to take into account uncertainty, but costs decreased over time whatever the method used.
Supplementary document for Free-space quantum key distribution over daylight and night time - 6969842.pdf
Creators: name: Cai, Wen-Qi
name: Li, Yang
name: Li, Bo
name: Ren, Ji-Gang
name: Liao, Shengkai
name: Cao, Yuan
name: Zhang, Liang
name: Yang, Meng
name: Wu, Jincai
name: Li, Yu-Huai
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Detailed data
SUN'IY INTELLEKT YORDAMIDA VIDEO VA AUDIO FAYLLAR YARATISH TEXNOLOGIYASI
Creators: name: Ablizova, Gulzahiryam
name: Qalandarova, Shahzoda
Publisher: name: Zenodo
Year: 2025

description: Hozirgi kunda sun’iy intellekt (AI) texnologiyalari turli sohalarda, jumladan, media va ko‘ngilochar sanoatida keng qo‘llanilmoqda. Ayniqsa, video va audio fayllar yaratishda sun’iy intellektning o‘rni sezilarli darajada ortdi. AI yordamida yaratish mumkin bo‘lgan media fayllar, an’anaviy usullarga qaraganda tezroq va samaraliroq amalga oshirilishi mumkin. Video va audio yaratishda AI texnologiyalarining kuchli yordami, asosan, avtomatik kontent yaratish, audio va video tahrir qilish, tarjima qilish va boshqa ko‘plab ilovalar orqali amalga oshiriladi. Ushbu maqolada AI yordamida video va audio fayllarni yaratish texnologiyalarining asosiy tamoyillari, ularning ishlash prinsiplari va imkoniyatlari ko‘rib chiqiladi.