cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Zum Einfluß geburtshilflich-perinatologischer Maßnahmen auf die Mortalität und Frühmorbidität von Frühgeborenen der Gewichtsklasse 500 bis 1500 Gramm = Effect of obstetric-perinatal measures on mortality and early morbidity of premature infants weighing 500 to 1,500 grams
Creators: name: Voigt, H. J.
name: Lang, N.
name: Segerer, Hugo
name: Stehr, K.
Publisher: name: Universität Regensburg
Year: 1989
Subjects: subject: 610 Medizin
subject: Asphyxia Neonatorum/mortality
subject: Birth Weight
subject: Cerebral Hemorrhage/mortality
subject: Cesarean Section
subject: Female
subject: Fetal Growth Retardation/mortality
subject: Fetal Membranes, Premature Rupture/mortality
subject: Germany, West/epidemiology
subject: Humans
subject: Infant, Newborn
subject: Infant, Premature, Diseases/mortality
subject: Pregnancy
subject: Prognosis
subject: Retrospective Studies
subject: Risk Factors

description: In a retrospective analysis of perinatal influencing factors in 186 premature newborns of the Department of Gynaecology of the University of Erlangen covering the period from 1982-1987 with birth weights between 500 and 1500 grams, the mortality and early morbidity were analysed, as characterised by cerebral haemorrhages, respiratory distress syndrome and infections insofar, as they had been connected with the obstetrical approach and paediatric intensive-care treatment, 45 infants born in 1982/83 were compared with 141 infants, who had been subjected to a different treatment approach during 1984 to 1987. During the second period, there was a marked drop both in mortality and in the incidence of asphyxia-induced severe cerebral haemorrhage and of the respiratory distress syndrome. A shortened latency period after premature rupture of the amnion, and a more pronounced presence of a neonatologically experienced team of paediatricians were found to be significant obstetric liberal influencing factors in determining the need to perform Caesarean section. The triplication of the frequency of Caesarean section observed resulted in a 50% reduction in perinatal mortality and morbidity. Infants with pelvic presentation benefited most from the more liberal performance of Caesarean section, as did infants with vertex presentation. Shortening of the latency phase in premature rupture resulted in a marked reduction in infection morbidity and mortality. Therefore we conclude, that the frequently practised procrastination with the aim to await an improvement in lung maturity should be replaced by a more active obstetric management, avoiding both infection and birth trauma. Obstetric decisions should be based rather on prenatal estimation of weight than on the calculated gestational age. At present, the lowest birth weight associated with the expectation of a healthy life is considered to be 750 grams.
In search of improved approaches to antibiotic stewardship : can we explain variations in physician practice patterns related to outpatient infection management?
Creators: name: McKay, Rachel Margaret
Publisher: name: University of British Columbia
Year: 2017

description: The discovery of antibiotics was one of the most significant advances in modern medicine; however, our reliance on antibiotics is threatened by the spread of resistance. Antibiotic resistance is a natural phenomenon that is exacerbated by selection pressure from antibiotic use. Where prescriptions are required for antibiotics, understanding prescribing behaviour is paramount. Guidelines recommend antibiotics for respiratory tract infections (RTIs) only when pneumonia or other serious complications are suspected. Urine cultures are recommended for complicated, but not uncomplicated, urinary tract infections (UTIs). The objectives of this thesis were to identify factors related to patients, physicians, and geographic regions associated with antibiotic use for RTIs, and urine culturing for UTI; and to explore the extent of variations in these practices across physicians. A systematic review of the literature was conducted to assess factors that have previously been empirically associated with antibiotic prescribing. Then, using linked administrative datasets, factors associated with antibiotic prescriptions for paediatric respiratory tract infection were analyzed. Urine culture data was subsequently linked in, to explore urine culturing practices. These analyses demonstrated that observed physician characteristics had a stronger influence on practice patterns that did differences in patient characteristics. In particular, physicians who had been in practice for longer tended to be more likely to prescribe antibiotics, and to order urine cultures. Physicians trained outside of Canada were more likely to prescribe, but less likely to order a urine culture. Female physicians were less likely to prescribe antibiotics, and more likely to order urine cultures. The variation between physicians that remained after accounting for observed characteristics was substantial. This research demonstrates some common features of physicians that are associated with antibiotic prescribing and urine culture use. However, the variation between physicians in practice styles is greater than the effects of these characteristics. These findings have implications for the design and implementation of antibiotic stewardship efforts to improve antibiotic use. For example, audit and feedback interventions and academic detailing have shown some promise, and may be particularly effective if targeted to physicians with higher prescribing or culturing practices. This thesis demonstrates the utility of administrative datasets in identifying such physicians.
Application of potential-sensitive fluorescent dyes in anion and cation-sensitive polymer membranes
Creators: name: Mohr, Gerhard J.
name: Murkovic, Ivana
name: Lehmann, Frank
name: Haider, Christian
name: Wolfbeis, Otto S.
Publisher: name: Universität Regensburg
Year: 1997
Subjects: subject: Optodes; Nitrate sensors; Nitrite sensors; Potassium sensors; Mercury sensors; Fluorescence; Polarity probes
subject: 540 Chemie

description: The applicability of two potential-sensitive dyes (PSDs) for optical sensing of ions is reported. In particular, nitrate and nitrite-responsive as well as potassium and mercury-sensitive polymer membranes have been developed. In general, membranes are composed of a plasticized polymer, an ion carrier and a fluorescent dye which optically transduces the extraction of the analyte ion in the polymer matrix. The nitrate sensor membrane is composed of rhodamine B octadecylester and the anion-exchange catalyst is tridodecylmethylammonium chloride. Both are dissolved in plasticized PVC. The nitrite sensor is based on the same dye and the same polymer matrix but with benzylbis (triphenylphosphine) palladium(II) chloride acting as the nitrite-selective carrier. The potassium sensor membrane consists of the carbocyanine dye DiOC16(3), valinomycin and a lipophilic borate salt. The mercury ‘sensor’ is based on the irreversible decomposition of borate by mercury ions and is composed of DiOC16(3) and borate only. All sensor membranes have been investigated in terms of signal change, sensitivity, stability, limits of detection and the selectivity for the analyte over interferent ions. The mechanism of the sensor membranes is discussed on the basis of changes of the microenvironment of solvatochromic dyes, which result in analyte-dependent signal changes.
title: Say on Pay
Creators: name: Larcker, David F.
name: Tayan, Brian
Publisher: name: Corporate Governance Research Initiative
Year: 2016

description: This Research Spotlight provides a summary of the academic literature on how shareholder voting on executive compensation plans influences executive pay. It reviews the evidence of: The impact of “vote no” campaigns, the impact of shareholder voting on equity compensation plans, the market reaction to say-on-pay legislation and proposals, and the impact of say on pay on future pay practices. This Research Spotlight expands upon issues introduced in the Quick Guide CEO Compensation.
Caustic Crossing Events and Source Models in Gravitational Lens Systems
Creators: name: Alexandrov, A. N.
name: Sliusar, V. M.
name: Zhdanov, V. I.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: High amplification events (HAEs) are common phenomena in extragalactic gravitational lens systems (GLSs), where the multiple images of a distant quasar are observed through a foreground galaxy. There is a considerable brightness magnification in one of the quasar images during HAE. Grieger, Kayser, and Refsdal (1988) proposed to use HAEs to study the central regions of quasars in GLSs. In this paper, we consider some problems concerning the identification of different source types on the basis of the HAE observations. We compare the results of light curve simulations to estimate a feasibility to distinguish different source models in GLSs. Analytic approximation methods yielding solutions of the lens equation in a vicinity of fold caustic crossing events are presented. The results are used to obtain amplification factors, which the higher-order corrections for the Gaussian, power-law, and limb-darkening models of a source take into account.
description: 12 pages, 6 figures, 43 references
Toward an Empirical Theory of Pulsar Emission. IX. On the Peculiar Properties and Geometric Regularity of Lyne & Manchester's "Partial Cone" Pulsars
Creators: name: Mitra, Dipanjan
name: Rankin, Joanna. M.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Lyne & Manchester (1988) identified a group of some 50 pulsars they called "partial cones" which they found difficult to classify and interpret. They were notable for their asymmetric average profiles and asymmetric polarization position-angle (PPA) traverses, wherein the steepest gradient (SG) point fell toward one edge of the total intensity profile. Over the last two decades, this population of pulsars has raised cautions regarding the core/cone model of the radio pulsar-emission beam which implies a high degree of order, symmetry and geometric regularity. In this paper we reinvestigate this population "partial cone" pulsars on the basis of new single pulse polarimetric observations of 39 of them, observed with the Giant Meterwave Radio Telescope in India and the Arecibo Observatory in Puerto Rico. These highly sensitive observations help us to establish that most of these "partial cones" exhibit a core/cone structure just as did the "normal" pulsars studied in the earlier papers of this series. In short, we find that many of these "partial cones" are partial in the sense that the emission above different areas of their polar caps can be (highly) asymmetric. However, when studied closely we find that their emission geometries are overall identical to core/double cone structure encountered earlier-that is, with specific conal dimensions scaling as the polar cap size.
description: Accepted for publication in ApJ, 42 pages with 45 figures, notes to table 2 and 3 are in the beginning of the appendix section
Fibrinpleurodese eines beidseitigen Spannungspneumothorax bei Mukoviszidose = Fibrin pleurodesis of bilateral tension pneumothorax in mucoviscidosis
Creators: name: Segerer, Hugo
name: Richter, K.
name: Scheele, J.
Publisher: name: Universität Regensburg
Year: 1984
Subjects: subject: 610 Medizin
subject: Adhesives
subject: Adolescent
subject: Cystic Fibrosis/complications
subject: Drainage
subject: Female
subject: Fibrin/therapeutic use
subject: Humans
subject: Pneumothorax/therapy

description: A bilateral recurrent tension pneumothorax in an 18-year-old patient with cystic fibrosis was treated by fibrin glue pleurodesis. Within the observation period of 20 months no relapse has occurred.
Atomistic structure of amorphous silicon nitride from classical molecular dynamics simulations
Creators: name: Ippolito, Mariella
name: Meloni, Simone
Publisher: name: arXiv
Year: 2011
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: By means of molecular dynamics simulations based on the Billeter et al. [S. R. Billeter, A. Curioni, D. Fischer, and W. Andreoni, Phys. Rev. B {\bf 73}, 155329] environment-dependent classical force field we studied the structural features of SiN$_x$ samples at various stoichiometries. Our results are in good agreement with experimental data and are able to reproduce some features which so far were not reproduced by simulations. In particular, we identified units containing N--N bonds, which are thought to be responsible for an unassigned peak in the radial distribution function obtained from neutron diffraction data and signals observed in electron spin resonance, X-ray photoemission spectroscopy, electron-energy-loss spectroscopy and optical absorption experiments. We have identified defects which are thought to be the responsible for the high concentration of charge traps that makes this material suitable for building non-volatile memory devices. We analyzed the dependency of the concentration of these defects with the stoichiometry of the sample.
Hydrogen Recombination with Multilevel atoms
Creators: name: De, Soma
name: Baron, E.
name: Hauschildt, Peter H.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Hydrogen recombination is one of the most important atomic processes in many astrophysical objects such as Type II supernova (SN~II) atmospheres, the high redshift universe during the cosmological recombination era, and H II regions in the interstellar medium. Accurate predictions of the ionization fraction can be quite different from those given by a simple solution if one takes into account many angular momentum sub-states, non-resonant processes, and calculates the rates of all atomic processes from the solution of the radiative transfer equation instead of using a Planck function under the assumption of thermal equilibrium. We use the general purpose model atmosphere code PHOENIX 1D to compare how the fundamental probabilities such as the photo-ionization probability, the escape probability, and the collisional de-excitation probability are affected by the presence of other metals in the environment, multiple angular momentum sub-states, and non-resonant processes. Our comparisons are based on a model of SN 1999em, a SNe Type II, 20 days after its explosion.
description: 29 pages, 12 figures, MNRAS, in press
Privacy, Security, and Nondiscrimination Best Practices for Direct-to-Consumer (DTC) Genetic Testing Companies
Creators: name: Hendricks-Sturrup, Rachele
name: Lu, Christine
Publisher: name: Center for ELSI Resources and Analysis
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Ethics
subject: Science
subject: ELSI
subject: data privacy
subject: direct-to-consumer genetic testing
subject: GINA
subject: genetic discrimination

description: The completion of the Human Genome Project opened new doors for business enterprise. One such activity is direct-to-consumer (DTC) genetic testing, or genetic testing offered on a service-driven basis, without the need for a clinician or other intermediary. DTC genetic testing has been, and continues to be, a burgeoning market and source of genetic data for original research that has produced new insights and discoveries in human ancestry and health. However, the data use practices of DTC genetic testing companies, including when and how they share consumer genetic data with third parties, are controversial. Also concerning is the fact that U.S. laws like the Genetic Information Nondiscrimination Act (GINA), which is intended to protect individuals from genetic discrimination by employers and health insurers, contain critical protection gaps (i.e., they do not apply to life, disability, and long-term care insurers). States are then left to create their own laws to fill those protection gaps, such as, for example, CalGINA in the state of California. As consumers and the media became increasingly aware of law enforcement requests for consumer genetic testing data, the health care business interests of DTC genetic testing companies, and gaps in existing legal protections like GINA, stakeholders in government, health care, and other sectors sought to develop and/or endorse privacy, security, and nondiscrimination best practices for DTC companies. Several of these companies also convened to develop and endorse privacy best practices. This collection includes literature that: 1) examines the privacy policies and practices of major DTC genetic testing companies within the USA, UK, and China (only a few studies have systematically assessed privacy policies to date), 2) proposes genetic data governance, privacy, security, and nondiscrimination best practices and policy approaches aimed at avoiding genetic data misuse in a range of settings, including employment, and 3) explores stakeholder perspectives and social practices regarding the use, misuse, commercialization, and sharing of consumer genetic information. It will be useful to audiences seeking to understand the current state of discussions about privacy, security, and nondiscrimination best practices for DTC genetic testing companies operating globally as well as the perspectives and concerns of diverse stakeholders
The development of surface geochemical technologies for the detection of kimberlites concealed by glacial drift in the Northwest Territories, Canada
Creators: name: Cayer, Erika Mary
Publisher: name: University of British Columbia
Year: 2017

description: Many diamondiferous kimberlites in the Lac de Gras region of the Northwest Territories are concealed by several metres of glacial drift and are therefore challenging to detect by traditional exploration techniques. Soil samples were collected in a 50x60 metre grid crossing the DO-18 kimberlite (Peregrine Diamonds Ltd.), concealed by 5-20 metres of glacial sediments, to evaluate the potential of surface geochemical target discrimination techniques to detect the presence of a kimberlite through cover. Physicochemical measurements were recorded at each sample site, and soil samples were analysed by ICP-MS following 4-Acid, Aqua Regia and De-Ionized Water digestions, as well as field portable X-Ray Fluorescence (fp-XRF), spatiotemporal geochemical hydrocarbons (SGH), and select samples by X-Ray Diffraction (XRD) and Sequential Leach. AGI Inc. Goresorber™ Hydrocarbon Collectors were also installed at each site. Surficial material, soil type, topographic variation and vegetation were mapped to give insight to the influences of geomorphological processes on geochemistry. An east-west trending slope break divides the research site into a topographically high region in the north, and a low-lying region in the south. The north consists of till, and the south comprises till, organics and glaciofluvial and glaciolacustrine sediments. 4-Acid and Aqua Regia digestion data display a dispersal of Cr, Mg, Nb, and Ni from directly above the kimberlite in the north, to the edge of the sampling grid, in the down-ice direction. Fp-XRF data exhibits a similar distribution in all elements except Mg, as does SGH data in light benzenes. Ni and Mg concentrations in the kimberlite demonstrate that it is the source of the geochemical anomalies. Glacial transport is hypothesized to have generated the geochemical anomalies, and glaciolacustrine and glaciofluvial processes are considered to have generated the lower topography and diluted the geochemical responses in the south.
A Phase 3 trial analysis proposal for mitigating the impact of the COVID-19 pandemic
Creators: name: Hua, Eva
name: Janocha, Reinhold
name: Severin, Thomas
name: Wei, Jiawei
name: Vandemeulebroecke, Marc
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Two pivotal, randomized, double-blind studies in a chronic dermatology disease were ongoing when the COVID-19 pandemic broke out. The trials had identical design, with four parallel treatment arms: two doses of active drug, an active comparator and placebo. When recruitment was temporarily halted due to the pandemic, both trials had already achieved over 80% of the targeted sample size. The unprecedented and unpredictable dynamic of the pandemic caused concerns about potential risks to data integrity and interpretability, which needed to be addressed. In this paper, we describe some of these challenges and mitigation strategies. In particular, the complex confirmatory situation involving multiple active doses, endpoints and comparators led to a careful modification of the testing scheme to maintain the power of key endpoints and comparisons while still controlling the relevant type I error rates. Specifically, the strategy was adjusted to perform some lower-level statistical tests in the hierarchy on the pool of both studies, taking advantage of the replicate study design. Primary endpoint comparisons against placebo and active control remained separately by study. In this article, we share our ideas and experiences in devising this risk mitigation proposal for the statistical methodology of these pivotal trials during the COVID-19 pandemic.
Asymptotics of Random Contractions
Creators: name: Hashorva, Enkelejd
name: Pakes, Anthony G.
name: Tang, Qihe
Publisher: name: arXiv
Year: 2010
Subjects: subject: Probability (math.PR)
subject: Risk Management (q-fin.RM)
subject: FOS: Mathematics
subject: FOS: Economics and business
subject: 60F05, 60G70

description: In this paper we discuss the asymptotic behaviour of random contractions $X=RS$, where $R$, with distribution function $F$, is a positive random variable independent of $S\in (0,1)$. Random contractions appear naturally in insurance and finance. Our principal contribution is the derivation of the tail asymptotics of $X$ assuming that $F$ is in the max-domain of attraction of an extreme value distribution and the distribution function of $S$ satisfies a regular variation property. We apply our result to derive the asymptotics of the probability of ruin for a particular discrete-time risk model. Further we quantify in our asymptotic setting the effect of the random scaling on the Conditional Tail Expectations, risk aggregation, and derive the joint asymptotic distribution of linear combinations of random contractions.
description: 25 pages
Effects of the polymer matrix on an optical nitrate sensor based on a polarity-sensitive dye
Creators: name: Mohr, Gerhard J.
name: Wolfbeis, Otto S.
Publisher: name: Universität Regensburg
Year: 1996
Subjects: subject: Optodes; Nitrate sensors; Anion sensors; Fluorescence; Polarity probes
subject: 540 Chemie

description: A membrane responsive to nitrate has been developed; it is composed of a polymer matrix, an anion exchanger (tridodecylmethyl-ammonium chloride), and a polarity-sensitive dye (rhodamine B octadecyl ester perchlorate). On exposure to nitrate, its fluorescence intensity increases, while the wavelength of the excitation and emission maxima remain unchanged. The effect of the polymer matrix on the relative signal change, sensitivity and selectivity has been investigated. It is shown that the sensitivity and selectivity for nitrate over other anions strongly depends on the lipophilicity and polarity of the polymer: increasing lipophilicity results in both higher sensitivity and selectivity. The limit of detection (LOD) in the case of lipophilic matrices is of the order of 0.1 ppm nitrate, and highest signal changes are observed between 1 and 100 ppm. Hydrophilic matrices have an LOD of 1 ppm and are most sensitive to nitrate at levels between 10 and 1000 ppm. The selectivity factor of lipophilic matrices for nitrate over chloride is 200, whereas it is around 10 only in hydrophilic matrices. The optical signal of the sensor material is pH dependent and this dependence again is affected by the lipophilicity of the matrix. in general, lower lipophilicity increases the cross-sensitivity of the nitrate sensor to pH. As a result, the response of the sensor may be fine-tuned by the appropriate choice of the polymer material.
One-loop quantum cosmological correction to the gravitational constant using the kink solution in de Sitter universe
Creators: name: Darabi, F.
name: Jalalzadeh, S.
Publisher: name: arXiv
Year: 2010
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this paper, we show the equivalence between a classical static scalar field theory and the (closed) de Sitter cosmological model whose potential represents shape invariance property. Based on this equivalence, we calculate the one-loop quantum cosmological correction to the ground state energy of the kink-like solution in the (closed) de Sitter cosmological model in which the fluctuation potential $V^{\prime\prime}$ has a shape invariance property. It is shown that this type of correction, which yields a renormalized mass in the case of scalar field theory, may be {\it interpreted} as a renormalized gravitational constant in the case of (closed) de Sitter cosmological model. Keywords: One-loop correction; kink energy; shape invariance; zeta function regularization; de Sitter universe.
description: 18 pages
Nitrate-selective optical sensor applying a lipophilic fluorescent potential-sensitive dye
Creators: name: Huber, Christian
name: Klimant, Ingo
name: Krause, Christian
name: Werner, Tobias
name: Wolfbeis, Otto S.
Publisher: name: Universität Regensburg
Year: 2001
Subjects: subject: 540 Chemie

description: An optical sensor has been developed for continuous determination of nitrate that is based on a polymer-stabilized emulsion system consisting of a hydrogel with entrapped plasticizer droplets. The droplets contain a cationic potential-sensitive fluorescent dye (PSD) located near its surface. The cationic PSD also acts as an anion-exchange catalyst that extracts nitrate out of the aqueous solution to form a complex (PSD+/NO3−) that moves into the plasticizer droplet due to its lipophilicity. This process causes a decrease of micro-polarity near the dye, resulting in an increase in the fluorescence intensity of the PSD. In a second detection scheme, the fluorescence intensity information of the PSD is converted into a fluorescence phase shift by mixing into the membrane particles that contain an inert long-lifetime reference luminophore. The second sensing scheme is referred to as “dual lifetime referencing”. Both schemes can be used for reversible sensing of nitrate in the 0.1–50mM range, with response times in the order of 3 mi
Quantifying efficiency gains of innovative designs of two-arm vaccine trials for COVID-19 using an epidemic simulation model
Creators: name: Johnson, Rob
name: Jackson, Chris
name: Presanis, Anne
name: Villar, Sofia S.
name: De Angelis, Daniela
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Clinical trials of a vaccine during an epidemic face particular challenges, such as the pressure to identify an effective vaccine quickly to control the epidemic, and the effect that time-space-varying infection incidence has on the power of a trial. We illustrate how the operating characteristics of different trial design elements may be evaluated using a network epidemic and trial simulation model, based on COVID-19 and individually randomised two-arm trials with a binary outcome. We show that “ring” recruitment strategies, prioritising participants at imminent risk of infection, can result in substantial improvement in terms of power in the model we present. In addition, we introduce a novel method to make more efficient use of the data from the earliest cases of infection observed in the trial, whose infection may have been too early to be vaccine-preventable. Finally, we compare several methods of response-adaptive randomisation, discussing their advantages and disadvantages in the context of our model and identifying particular adaptation strategies that preserve power and estimation properties, while slightly reducing the number of infections, given an effective vaccine.
Impedometric herbicide chemosensors based on molecularly imprinted polymers
Creators: name: Panasyuk-Delaney, Tanya
name: Mirsky, Vladimir M.
name: Ulbricht, Mathias
name: Wolfbeis, Otto S.
Publisher: name: Universität Regensburg
Year: 2001
Subjects: subject: Molecular imprinting; Capacitive sensor; Chemical sensor; Grafting polymerization; Photopolymerization
subject: 540 Chemie

description: The technique of grafting polymerization has been used for preparation of thin films of molecularly imprinting polymers on the surface of polypropylene membranes and on hydrophobized gold electrodes. The herbicide desmetryn was used as a template. The solid supports used were hydrophobic, while the polymerwas hydrophilic. The adsorbed layer of benzophenone, irradiated by UV-light, initiated a radical polymerization near the surface. Polymer films were characterized by weighing, contact angle measurements and impedance spectroscopy. The electrodes coated with the molecularly imprinted polymers displayed fairly specific binding of desmetryn, as detected by the decrease in the capacitance of the electrode. Only small capacitive effects were observed on addition of terbumeton or atrazine, while metribuzine displayed capacitance decrease similar to desmetryn.
A simple strategy for preparation of sensor arrays: molecularly structured monolayers as recognition elements
Creators: name: Hirsch, Thomas
name: Kettenberger, Hubert
name: Wolfbeis, Otto S.
name: Mirsky, Vladimir M.
Publisher: name: Universität Regensburg
Year: 2003
Subjects: subject: 540 Chemie

description: The spreader-bar approach is a simple method for producing a huge variety of receptors with different selectivities. A sensor-array consisting of five such receptors is presented. A pattern recognition provides selective detection of different purines and pyrimidines.
Hydrodynamics from dynamical non-equilibrium MD
Creators: name: Orlandini, Sergio
name: Meloni, Simone
name: Ciccotti, Giovanni
Publisher: name: arXiv
Year: 2011
Subjects: subject: Computational Physics (physics.comp-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We review a dynamical approach to non-equilibrium MD (D-NEMD). We show how, using a proper simulation setup, is possible to treat interesting cases in which the initial condition is a stationary non-equilibrium state produced by a suitable dynamical system. We then extend the class of non-equilibrium phenomena that can be studied by atomistic simulations to the case of complex initial conditions consisting in assigning a macroscopic value of a scalar or vector observable or a field. We illustrate the functioning of this method by applying it to the relaxation of an interface between two immiscible liquids. We have shown that our method generate unbiased results while this might not be the case for the often used short time average approach.
Probing a critical length scale at the glass transition
Creators: name: Mosayebi, Majid
name: Del Gado, Emanuela
name: Ilg, Patrick
name: Ottinger, Hans Christian
Publisher: name: arXiv
Year: 2010
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We give evidence of a clear structural signature of the glass transition, in terms of a static correlation length with the same dependence on the system size which is typical of critical phenomena. Our approach is to introduce an external, static perturbation to extract the structural information from the system's response. In particular, we consider the transformation behavior of the local minima of the underlying potential energy landscape (inherent structures), under a static deformation. The finite-size scaling analysis of our numerical results indicate that the correlation length diverges at a temperature $T_c$, below the temperatures here the system can be equilibrated. Our numerical results are consistent with random first order theory, which predicts such a divergence with a critical exponent $ν=2/3$ at the Kauzmann temperature, where the extrapolated configurational entropy vanishes.
description: 5 pages, 5 figures, to appear in Phys. Rev. Lett. 2010.
Reproducible Computational Environments
Creators: name: Gibson, Sarah
Publisher: name: Zenodo
Year: 2022

description: Presentations delivered as part of a community call for Reproducible Research Oxford on Reproducible Computational Environments. Other talks in the call can be found here: https://osf.io/xp9zn/ The introduction talk contains information about what a computational environment is, what makes them reproducible and why you should care about this reproducibility. It then introduces the tools that will be covered throughout the rest of the call. The second talk then covers repo2docker as a tools to automate the building of environments drawing on some of the previous tools mentioned in the series. And then demonstrates how Binder can improve the accessibility of these repo2docker environments by leveraging the cloud to make them interactive in the cloud.
Constraints on the Wtb vertex from early LHC data
Creators: name: Aguilar-Saavedra, J. A.
name: Castro, N. F.
name: Onofre, A.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We use the recent measurements of top quark decay asymmetries in ATLAS and the t-channel single top cross section in CMS to set the first combined LHC limits on the Wtb vertex. This combination allows to obtain much better limits than the separate measurements. The resulting constraints are comparable, although still weaker, than the ones obtained using Tevatron data with much more statistics.
description: RevTeX 4 pages
Open Science - What is it all about?
Creators: name: Karoune, Emma
Publisher: name: Zenodo
Year: 2022
Subjects: Open Science
Open data
FAIR
Open source
Open access

description: This presentation was given on Friday 14th January 2022 as part of the EU funded project entitled "Opening Doors" (https://openingdoors4phd.eu). This is the first lecture about Open Science and covers what is an open science approach, what are the different practices that make up open science and then it goes on to give examples of these practices. The slides build on the resources created in the Open Science Skills Workshop - these resources can be found here: https://doi.org/10.5281/zenodo.5717154
Sol-gel-derived optical coatings for determination of chromate
Creators: name: Zevin, Michael
name: Reisfeld, Renata
name: Oehme, Ines
name: Wolfbeis, Otto S.
Publisher: name: Universität Regensburg
Year: 1997
Subjects: subject: Chromate sensors; Optical coatings; Sol-gel technique
subject: 540 Chemie

description: An optical probe for chromate ion has been obtained by the sol-gel technique by depositing a porous film containing the reagent diphenylcarbazide on a glass support. Changes in the absorption of light as a result of the (irreversible) formation of a purple product between chromate and the reagent inside the sol-gel are monitored. The detection limit for chromate anion is as low as 1 ppb, but only after rather long exposure to samples. The morphology of the surface of the film has been studied using atomic force microscopy and is related to the technique of preparing the film.
Optical ozone detection by use of polyaniline film
Creators: name: Ando, Masanori
name: Swart, Claudia
name: Pringsheim, Erika
name: Mirsky, Vladimir M.
name: Wolfbeis, Otto S.
Publisher: name: Universität Regensburg
Year: 2002
Subjects: subject: Optical ozone detection; Polyaniline film; Visible near-IR absorption
subject: 540 Chemie

description: We report on the optical ozone sensitivity of a polyaniline (PANI) film prepared on the inner wall of a polystyrene cuvette by chemical oxidation of aniline from aqueous solution. The PANI film showed changes of optical absorbance in the presence of 50–100 ppm ozone in air at room temperature. The absorbance change was largest at wavelengths in the range of 500–800 nm. The absorbance changes brought about by ozone was partially reversible after removal of ozone from the atmosphere. These results suggest that PANI is a potential material for optical ozone detection.
Design and characterisation of mutant and wild-type huntingtin proteins produced from a toolkit of scalable eukaryotic expression systems
Creators: name: Harding, Rachel
Publisher: name: Zenodo
Year: 2019
Subjects: neurodegeneration
protein purification
biophysics
small-angle X-ray scattering (SAXS)
protein expression
molecular dynamics
Huntington disease

description: Poster for CHDI 14th Annual HD Therapeutics Conference

Abstract: The gene mutated in individuals with Huntington’s disease (HD) encodes the 348-kDa huntingtin (HTT) protein. Pathogenic HD CAG-expansion mutations create a polyglutamine (polyQ) tract at the N terminus of HTT that expands above a critical threshold of ~35 glutamine residues. The effect of these HD mutations on HTT is not well understood, in part because it is difficult to carry out biochemical, biophysical, and structural studies of this large protein. To facilitate such studies, here we have generated expression constructs for the scalable production of HTT in multiple eukaryotic expression systems. Our set of HTT expression clones comprised both N- and C-terminally FLAG-tagged HTT constructs with polyQ lengths representative of the general population, HD patients, and juvenile HD patients, as well as the more extreme polyQ expansions used in some HD tissue and animal models. Our expression system yielded milligram quantities of pure recombinant HTT protein, including many of the previously mapped post-translational modifications. We characterized both apo and HTT–HTT-associated protein 40 (HAP40) complex samples produced with this HD resource, demonstrating that this toolkit can be used to generate physiologically meaningful HTT complexes. We further demonstrate that these resources can produce sufficient material for protein-intensive experiments, such as small-angle X-ray scattering (SAXS), providing biochemical insight into full-length HTT protein structure. The work outlined and the tools generated here lay a foundation for further biochemical and structural work on the HTT protein and for studying its functional interactions with other biomolecules.
description: Dr. Harding is the recipient of the Huntington's Disease Society of America Berman Topper Career Development Fellowship which funds and supports this research, in addition to generous funding from the CHDI Foundation and the Huntington Society of Canada. The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Ontario Ministry of Research, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome.
Augmented Recursion For One-loop Amplitudes
Creators: name: Dunbar, David C.
name: Ettle, James H.
name: Perkins, Warren B.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We present a semi-recursive method for calculating the rational parts of one-loop amplitudes when recursion produces double poles. We illustrate this with the graviton scattering amplitude M^{1-loop}(1-, 2+, 3+, 4+, 5+).
description: 6 pages, 3 figures. To appear in the proceedings of Loops and Legs 2010
The Turing Way Book Dash November 2021
Creators: name: Way, The Turing
Publisher: name: Zenodo
Year: 2021

description: Slides and talk by Malvika Sharan and Kirstie Whitaker on behalf of the Book Dash planning committee members Arielle Bennett, Batool Almarzouq, Brigitta Scipoz, Carlos Martinez, Emma Karoune, Esther Plomp. You can watch video recording on YouTube.
Dwelling in the wilderness : place, landscape and the sacred among catholic monks of the American west
Creators: name: Brown, Jason M.
Publisher: name: University of British Columbia
Year: 2017

description: A monk’s purpose is to seek God, and contemplative monks in the Roman Catholic tradition are specifically called to seek God in place. Drawing from biblical motifs, religious symbols, spiritual teachings and monastic traditions, monastic communities have forged deep and abiding relationships with their rural and wild locales. While many of the studies concerning monasticism’s relationship to land engage historical and theological dimensions, far fewer give adequate voice to the range of lived perspectives of contemporary monks themselves. Exploring research questions focused on the relationship between environmental discourses and contemporary monastic spirituality, during field work conducted between December 2015 and May 2016, I interviewed 50 male monastics at four monastic communities through both seated and walking interviews. Embedded in the interdisciplinary literature of place and landscape studies, my findings are interpreted through the lens of recent debates regarding the role of cognitively or socially constructed discourses in the experience of landscape. Socially constructed or “representational” perspectives emphasize the semiotic character of experience and meaning making with place and landscape. Rooted in identity, gender, class, ideology or religion, we project meaning onto an otherwise meaningless objective landscape. More recent phenomenological approaches attempt to shift away from any vestiges of Cartesian dualism between subject and object by rejecting representational or symbolic understandings of experience for an emphasis on pre-cognitive, embodied, sensory experience as the fundamental driver of our experience of land and place. I argue that contemporary monasticism, rooted in both symbolic religious constructions and powerful spiritual experiences of land, has engaged environmental discourse through ‘bridging,’ a practice which attempts to assimilate environmental discourse into monastic spirituality on its own terms. The monastic sense of place, the question of ‘sacred’ land, and the observation of religious symbols in land demonstrate what I call an embodied semiotics wherein established religious and environmental discourses are relationally attached to and molded by embodied contact and experience with land.
title: Quartierspiegel Hirslanden 2024
Creators: name: (:Unkn) Unknown
Publisher: name: Zentralbibliothek Zürich
Year: 2024
Subjects: subject: 314 Allgemeine Statistiken zu Europa
subject: 710 Städtebau, Raumplanung, Landschaftsgestaltung
subject: 949 Geschichte anderer Teile Europas
subject: Zürich-Hirslanden
subject: Zürich / Kreis 7
subject: Quartier
subject: Amtliche Statistik
subject: Bevölkerungsstatistik

description: Von der Getreidesorte, die dem Quartier Hirslanden einst seinen Namen gab, zeugt die unter Denkmalschutz stehende Hirslandermühle. Historisch gilt die Gemeinde eher als Streusiedlung, und ihr Grünanteil ist entsprechend hoch.
Sonographischer Nachweis von Hirntumoren im Säuglingsalter = Ultrasonographic Demonstration of Brain Tumors in Infancy
Creators: name: Deeg, K. H.
name: Segerer, Hugo
name: Harms, D.
Publisher: name: Universität Regensburg
Year: 1985
Subjects: subject: 610 Medizin
subject: Brain Neoplasms/congenital
subject: Cerebellar Neoplasms/congenital
subject: Cerebral Ventricle Neoplasms/congenital
subject: Choroid Plexus/pathology
subject: Echoencephalography/methods
subject: Female
subject: Humans
subject: Hydrocephalus/diagnosis
subject: Infant
subject: Infant, Newborn
subject: Male
subject: Medulloblastoma/congenital
subject: Neoplasms, Germ Cell and Embryonal/congenital
subject: Papilloma/congenital
subject: Tomography, X-Ray Computed

description: Using the open fontanelle as an acoustic window brain tumours were diagnosed by gray scale ultrasonography in 3 infants aged 1 day to 5 months. The tumours were characterized by their echo dense structure and their good delimination from the surrounding brain. In 2 children the tumour was localized infratentorially (medulloblastoma and unclassified neuroectodermal tumour) and had caused an occlusive hydrocephalus. Both children died aged 3 and 5 months in central nervous dysregulation. One child suffered from plexus papilloma which had caused a hypersecretory hydrocephalus. After resection of the tumour the hydrocephalus decreased without any further treatment. Comparison with axial computed tomography and autopsy findings showed, that gray scale ultrasonography is equally efficient in diagnosing brain tumours and associated hydrocephalus.
Die Bedeutung von Serumglukose, Uringlukose und HbAlc bei der Langzeitüberwachung juveniler Diabetiker = The value of serum glucose, urine glucose and hbAIc for long term metabolic information in juvenile diabetics (author's transl.)
Creators: name: Böhles, H.
name: Segerer, Hugo
Publisher: name: Universität Regensburg
Year: 1980
Subjects: subject: 610 Medizin
subject: Adolescent
subject: Adult
subject: Blood Glucose/analysis
subject: Child
subject: Diabetes Mellitus, Type 1/urine
subject: Female
subject: Glucose
subject: Glycosuria
subject: Hemoglobins/analysis
subject: Humans
subject: Male
subject: Mathematics
subject: FOS: Mathematics
subject: Time Factors

description: In 43 insuline dependent diabetics postprandial serum glucose concentrations as 24-hour glucose excretions have been determined. Their value for a long term metabolic information was compared to that of HbAIc concentrations. A correlation between postprandial serum glucose concentration of the partial correlations. Those excluded the influence of an interrelationship among the individual serum glucose concentrations, at the time of different presentations for metabolic control, on the serum glucose to HbAIc relationship. There was no correlation between the concentrations of HbAIc and the amount of glucose excreted into the urine. The study shows that single determinations of postprandial serum glucose concentrations, as the excretion of small amounts of glucose into the urine are of no use for a long term metabolic information in juvenile diabetics.
Highly accurate calculations of the rotationally excited bound states in three-body systems
Creators: name: Frolov, Alexei M.
name: Wardlaw, David M.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: An effective optimization strategy has been developed to construct highly accurate bound state wave functions in various three-body systems. Our procedure appears to be very effective for computations of weakly bound states and various excited states, including rotationally excited states, i.e. states with $L \ge 1$. The efficiency of our procedure is illustrated by computations of the excited $P^{*}(L = 1)-$states in the $ddμ, dtμ$ and $ttμ$ muonic molecular ions, $P(L = 1)-$states in the non-symmetric $pdμ, ptμ$ and $dtμ$ ions and $2^{1}P(L = 1)-$ and $2^{3}P(L = 1)-$states in He atom(s).