title: ÐÐ¾Ð¼Ð¿Ð¾Ð·Ð¸ÑÐ¸Ð¾Ð½Ð½ÑÐµ Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ½ÑÐµ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ñ Ð´Ð»Ñ Ð»ÐµÑÐµÐ½Ð¸Ñ Ð·Ð»Ð¾ÐºÐ°ÑÐµÑÑÐ²ÐµÐ½Ð½ÑÑ Ð¾Ð¿ÑÑ Ð¾Ð»ÐµÐ¹ ÐºÐ¾ÑÑÐµÐ¹ Ð¸ Ð²Ð¾ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð¸Ñ ÐºÐ¾ÑÑÐ½ÑÑ Ð´ÐµÑÐµÐºÑÐ¾Ð²
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Composite polymer materials for the treatment of malignant bone tumors and the replacement of bone defects
Creators: name: Ð¨Ð¸ÑÐ¾Ð²Ð°, ÐÐ½Ð°ÑÑÐ°ÑÐ¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2021
Subjects: ÐºÐ¾Ð¼Ð¿Ð¾Ð·Ð¸ÑÐ¸Ð¾Ð½Ð½ÑÐµ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ñ
Ð¿Ð¾Ð»Ð¸Ð»Ð°ÐºÑÐ¸Ð´
Ð¿Ð¾Ð»Ð¸ÐºÐ°Ð¿ÑÐ¾Ð»Ð°ÐºÑÐ¾Ð½
ÐºÐ»Ð¾Ð·Ð¾-Ð±Ð¾ÑÐ°ÑÑ
Ð¸Ð½Ð¶ÐµÐ½ÐµÑÐ¸Ñ ÐºÐ¾ÑÑÐ½Ð¾Ð¹ ÑÐºÐ°Ð½Ð¸
Ð±Ð¾Ñ-Ð½ÐµÐ¹ÑÑÐ¾Ð½ Ð·Ð°Ñ Ð²Ð°ÑÐ½Ð°Ñ ÑÐµÑÐ°Ð¿Ð¸Ñ
Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÑ
Ð¾ÑÑÐµÐ¾ÑÐ°ÑÐºÐ¾Ð¼Ð°
Ð±Ð¸Ð¾Ð´ÐµÐ³ÑÐ°Ð´Ð¸ÑÑÐµÐ¼ÑÐµ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ñ
composite materials
polylactide
polycaprolactone
closo-borates
bone tissue engineering
boron-neutron capture therapy
polymers
osteosarcoma
biodegradable materials

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description: The given work is devoted to the preparation and study of the properties of biodegradable composite polymer materials for bone engineering containing closo-borates as potential drugs for boron-neutron capture therapy of malignant bone tumors. We tested different approaches to obtaining composite materials. At the first stage, we obtained polymer materials with carboxyl and amino groups on the surface. We studied the rate of adsorption of closo-borates to the surface of these materials and the rate of desorption closo-borates from the surface. At the second stage, we created composite polymer materials with closo-borates added to the polymer mass. The rate of degradation of the obtained materials under physiological conditions was studied. We studied the surface morphology of the obtained materials using optical microscopy and scanning electron microscopy. We also investigated the mechanical properties using the uniaxial stretching method. As a result, various composite polymer materials with closo-borates were obtained. These materials are suitable for the manufacture of scaffolds for bone tissue engineering and boron-neutron capture therapy.