cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Funktionelle Analyse von 13-Lipoxygenaseabgeleiteten Oxylipinen in der Pathogenabwehr von Solanum tuberosum L.
Creators: name: Altmann, Simone
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2009
Subjects: subject: Kartoffelkrankheit
subject: Oxylipine
subject: Hochschulschrift
subject: Online-Publikation
subject: 571.9623952
subject: 570

description: Oxylipine sind pflanzliche Sekundärmetaboliten, die aus dem Lipoxygenase- (LOX-) Weg stammen, in dem mehrfach ungesättigte Fettsäuren oxygeniert und weiter metabolisiert werden. Es ist bekannt, dass die 13-LOX-abgeleiteten Verbindungen 12-oxo-Phytodiensäure (OPDA) und Jasmonsäure (JA) Signalkomponenten sind, die als Antwort auf Pathogen- und Herbivorbefall an der Generierung von transkriptionellen Änderungen beteiligt sind und so zur Regulation der pflanzlichen Abwehr beitragen. Außerdem besitzen einige Oxylipine, wie das OPDA antimikrobielle Aktivitäten. In dieser Arbeit wurde die Rolle von JA und seiner Biosynthesevorstufe OPDA für die Abwehr von Kartoffel gegenüber Pathogenen näher untersucht. Zu diesem Zweck wurden RNA-Interferenz- (RNAi-) Konstrukte gegen die Allenoxid-Cyclase (StAOC), 12-oxo-Phytodiensäure-Reduktase (StOPR3) und das CORONATINE INSENSITIVE-Gen (StCOI1) in Kartoffelpflanzen exprimiert, um die OPDA- und JA-Biosynthese bzw. die JA-Perzeption zu reduzieren. In diesen transgenen Pflanzen wurde der von Pep-13, einem pathogen associated molecular pattern (PAMP) aus Phytophthora-Spezies, induzierte Signalweg analysiert. Zusammen mit bereits bekanten Daten von NahG-exprimierenden Kartoffelpflanzen, denen die Signalkomponente Salizylsäure (SA) fehlt, konnte ein Modell aufgestellt werden, in dem beide Signalkomponenten, JA und SA, für eine vollständige Pflanzenantwort benötigt werden. Weiterhin wurde die globale Genexpression nach Pep-13-Behandlung und deren Abhängigkeit von einem funktionalen JA-Biosynthese- bzw. Signalweg untersucht. Hierzu wurden Microarray-Analysen unter Verwendung der entsprechenden StAOC-, StOPR3- and StCOI1-RNAi-Pflanzen durchgeführt. Aus diesen Analysen konnten Oxylipin-abhängig Pep-13-regulierte Kandidatengene identifiziert werden, von denen einige in ihrem Pep-13-regulierten Expressionsprofil bestätigt werden konnten. Außerdem wurde mit der Charakterisierung und funktionellen Analyse eines Kandidatengens – des StJAZ – begonnen. Zusätzlich zu der Analyse der PAMP-vermittelten Abwehr wurde das Wachstum des Oomyceten Phytophthora infestans auf JA- und OPDA-defizienten bzw. im JA-Signalweg beeinträchtigten Pflanzen mit Hilfe einer quantitativen real-time PCR-Methode bestimmt. Sowohl der verminderte Gehalt an OPDA oder JA, als auch die inhibierte JA-Signalwahrnehmung in den transgenen Pflanzen hatten keinen messbaren Einfluss auf die Interaktion von Kartoffel mit P. infestans.
title: Zur Erinnerung an Robert Diethelm
title: geboren den 1. Dezember 1851, gestorben den 28. Dezember 1921
titleType: Subtitle
Creators: name: Oettli, Samuel
Publisher: name: Zentralbibliothek Zürich
Year: 1921
Subjects: subject: 920 Biografien, Genealogie, Insignien
subject: Nachruf

description: Enthält: Gedächtnisrede gehalten bei der Trauerfeier am 30. Dezember 1921 im neuen Krematorium Zürich von Samuel Oettli, Pfarrer am Münster in Bern; Nachruf von A.G. in der Neuen Zürcher Zeitung No. 1888.
Charakterisierung des immunmodulatorischen Potentials von mesenchymalen Stammzellen und Keimzelltumor-Zelllinien
Creators: name: Döring, Olivia
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2011
Subjects: subject: Online-Publikation
subject: Hochschulschrift
subject: 571.9

description: Mesenchymale Stammzellen (MSC) und embryonale Karzinom (EC)-Zellen von Keimzelltumoren (KZT) stellen immunpriviligierte Stammzellen bzw. Tumorstammzellen dar. Obwohl der immunogene Phänotyp von MSC und KZT bisher nicht detailliert untersucht wurde, kommen MSC zur Behandlung vieler Krankheiten zum Einsatz während EC-Zellen Zielstrukturen der Tumortherapie darstellen. Das Ziel der Dissertation bestand in der Charaktersierung der Expression, Regulation und Funktion von immunmodulatorischen Molekülen in beiden Zelltypen. Im Vergleich zu MSC gesunder Spender zeichneten sich MSC kranker Personen durch eine heterogene Expression von Komponenten der MHC-Klasse-I-Antigenprozessierungsmaschinerie (APM) aus. Nach der Differenzierung von MSC wurde eine Erhöhung der Proteinexpression von MHC-Klasse-I-APM-Komponenten detektiert. Die B7-H Moleküle wurden heterogen exprimiert. Für B7-H3 konnte eine protektive Rolle gegenüber der NK-Zell-vermittelten Lyse von MSC gezeigt werden. Die fehlende HLA-G-Expression in/auf MSC beruhte auf DNS-Methylierung und Histon-Acetylierung in immortalisierten MSC. Die Moleküle der MHC-Klasse-I-APM wurden in KZT-Zelllinien heterogen exprimiert. Die in vitro Differenzierung der EC Zelllinie H12.1 führte zu einer erhöhten Expression von Komponenten der MHC-Klasse-I-APM, was keinen Einfluss auf die T-Zell- und NK-Zell-Aktivierung hatte. Die B7-H1-Expression wurde in der Zelllinie JAR durch DNS-Methylierung reguliert. Zusammenfassend konnte die Charakterisierung des immunregulatorischen Potentials von MSC und KZT erweitert werden. Im Weiteren sollten die Untersuchungen auf mehr MSC-Spender ausgedehnt sowie der immunologische Phänotyp von MSC und KZT in funktionellen Experimenten verifiziert werden.
Influence of heavy modes on perturbations in multiple field inflation
Creators: name: Gao, Xian
name: Langlois, David
name: Mizuno, Shuntaro
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We investigate linear cosmological perturbations in multiple field inflationary models where some of the directions are light while others are heavy (with respect to the Hubble parameter). By integrating out the massive degrees of freedom, we determine the multi-dimensional effective theory for the light degrees of freedom and give explicitly the propagation matrix that replaces the effective sound speed of the one-dimensional case. We then examine in detail the consequences of a sudden turn along the inflationary trajectory, in particular the possible breakdown of the low energy effective theory in case the heavy modes are excited. Resorting to a new basis in field space, instead of the usual adiabatic/entropic basis, we study the evolution of the perturbations during the turn. In particular, we compute the power spectrum and compare with the result obtained from the low energy effective theory.
description: 24 pages, 13 figures; v2 substantial changes in sec.V; v3 matching the published version on JCAP
On the discrete spectrum of quantum layers
Creators: name: Lu, Zhiqin
name: Rowlett, Julie
Publisher: name: arXiv
Year: 2011
Subjects: subject: Spectral Theory (math.SP)
subject: Mathematical Physics (math-ph)
subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 58J50, 35Q40, 35J05

description: Consider a quantum particle trapped between a curved layer of constant width built over a complete, non-compact, $\mathcal C^2$ smooth surface embedded in $\mathbb{R}^3$. We assume that the surface is asymptotically flat in the sense that the second fundamental form vanishes at infinity, and that the surface is not totally geodesic. This geometric setting is known as a quantum layer. We consider the quantum particle to be governed by the Dirichlet Laplacian as Hamiltonian. Our work concerns the existence of bound states with energy beneath the essential spectrum, which implies the existence of discrete spectrum. We first prove that if the Gauss curvature is integrable, and the surface is weakly $κ$-parabolic, then the discrete spectrum is non-empty. This result implies that if the total Gauss curvature is non-positive, then the discrete spectrum is non-empty. We next prove that if the Gauss curvature is non-negative, then the discrete spectrum is non-empty. Finally, we prove that if the surface is parabolic, then the discrete spectrum is non-empty if the layer is sufficiently thin.
description: Clarifications and corrections to previous version, conjecture from previous version is proven here (Theorem 1.5), additional references included
A discrete model for the apparent viscosity of polydisperse suspensions including maximum packing fraction
Creators: name: Dörr, Aaron
name: Sadiki, Amsini
name: Mehdizadeh, Amirfarhang
Publisher: name: arXiv
Year: 2012
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Based on the notion of a construction process consisting of the stepwise addition of particles to the pure fluid, a discrete model for the apparent viscosity as well as for the maximum packing fraction of polydisperse suspensions of spherical, non-colloidal particles is derived. The model connects the approaches by Bruggeman and Farris and is valid for large size ratios of consecutive particle classes during the construction process, appearing to be the first model consistently describing polydisperse volume fractions and maximum packing fraction within a single approach. In that context, the consistent inclusion of the maximum packing fraction into effective medium models is discussed. Furthermore, new generalized forms of the well-known Quemada and Krieger equations allowing for the choice of a second-order Taylor coefficient for the volume fraction ($ϕ^2$-coefficient), found by asymptotic matching, are proposed. The model for the maximum packing fraction as well as the complete viscosity model are compared to experimental data from the literature showing good agreement. As a result, the new model is shown to replace the empirical Sudduth model for large diameter ratios. The extension of the model to the case of small size ratios is left for future work.
description: 14 pages, 4 figures
Estuary Classification Revisited
Creators: name: Guha, Anirban
name: Lawrence, Gregory A.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: This paper presents the governing equations of a tidally-averaged, width-averaged, rectangular estuary in completely nondimensionalized forms. Subsequently, we discover that the dynamics of an estuary is entirely controlled by only two variables: (i) the Estuarine Froude number, and (ii) a nondimensional number related to the Estuarine Aspect ratio and the Tidal Froude number. Motivated by this new observation, the problem of estuary classification is re-investigated. Our analysis shows that the two control variables are capable of completely determining the stratification at the estuary mouth, and therefore can specify the estuary type. The theoretical estuary classification scheme proposed in this paper is validated against real estuarine data collected from existing literature. Our classification scheme on comparison with the state-of-the-art theory shows significant improvement.
description: 6 pages, 4 figures
The impact of climate change on labour demand in the plantation sector: the case of tea production in Sri Lanka
Creators: name: Gunathilaka, Rajapaksha
name: Smart, James C. R.
name: Fleming, Christopher M.
name: Hasan, Syezlin
name: Gunathilaka, Rajapaksha
name: Smart, James C. R.
name: Fleming, Christopher M.
name: Hasan, Syezlin
Publisher: name: Unknown
Year: 2018
Subjects: subject: Environmental Economics and Policy
subject: farm level
subject: perennial crop
subject: profit function
subject: seemingly unrelated regression
subject: structural panel model

description: Limited opportunities for crop switching and lengthy preharvesting periods make the plantation sector particularly vulnerable to climate change. Surprisingly, however, the economic consequences of climate change on plantation crops are seldom analysed. Drawing on a unique primary panel data set from a representative cross section of 35 tea estates in Sri Lanka over the period 2002–2014, this study implements a structural model of estate profit maximisation to estimate the elasticity of labour demand with respect to different components of weather. Results indicate a negative relationship between labour demand and rainfall in the south-west monsoon, the north-east monsoon and the second inter-monsoon. A positive relationship is found between labour demand and rainfall in the first inter-monsoon. Overall, predicted changes in rainfall by 2050 are anticipated to reduce labour demand by approximately 1,175,000 person-days per year across Sri Lanka’s tea plantation sector. This is likely to have considerable social and welfare implications, particularly for the Indian Tamil women who comprise the majority of the sector’s workforce.
Periodic Signals in Binary Microlensing Events
Creators: name: Guo, Xinyi
name: Esin, Ann
name: Di Stefano, Rosanne
name: Taylor, Jeffrey
Publisher: name: arXiv
Year: 2011
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Gravitational microlensing events are powerful tools for the study of stellar populations. In particular, they can be used to discover and study a variety of binary systems. A large number of binary lenses have already been found through microlensing surveys and a few of these systems show strong evidence of orbital motion on the timescale of the lensing event. We expect that more binary lenses of this kind will be detected in the future. For binaries whose orbital period is comparable to the event duration, the orbital motion can cause the lensing signal to deviate drastically from that of a static binary lens. The most striking property of such light curves is the presence of quasi- periodic features, which are produced as the source traverses the same regions in the rotating lens plane. These repeating features contain information about the orbital period of the lens. If this period can be extracted, then much can be learned about the lensing system even without performing time-consuming, detailed light curve modeling. However, the relative transverse motion between the source and the lens significantly complicates the problem of period extraction. To resolve this difficulty, we present a modification of the standard Lomb-Scargle periodogram analysis. We test our method for four representative binary lens systems and demonstrate its efficiency in correctly extracting binary orbital periods.
Families’ experiences with medical research for pediatric rare diseases : a qualitative ethnographic study of parents and children participating in clinical trials for Duchenne muscular dystrophy (DMD)
Creators: name: Condin, Christopher J.
Publisher: name: University of British Columbia
Year: 2014

description: The biopharmaceutical industry has recently expanded its focus on developing new cures for rare diseases. As a growing number of personalised genomic treatments are tested in clinical trials, there is uncertainty about how to account for patient perspectives, and how to measure functional changes reported by patients and caregivers. The illness experiences of patients and families are also being reshaped as they adopt roles as collaborative stakeholders and participants in clinical studies. This dissertation examines these changes using data from qualitative ethnographic research conducted with families of children with Duchenne muscular dystrophy, a progressive and fatal genetic disease diagnosed in boys. Canadian and American families were followed using semi-structured interviews and observational methods as they participated in clinical trials testing a genomic treatment for DMD, called ataluren (formerly known as PTC124). Ethnographic work was also carried out with physicians, patient-advocates, and other professionals engaged in clinical neuromuscular research. The dissertation contributes to scholarly understanding of families’ everyday experiences in the clinical trial, the significance and meaning of investigational treatments from the patient perspective, and the social context in which pharmaceutical development for rare diseases occurs. I show how genetic research is reconfiguring patient communities and altering moral sensibilities about treatment and care, by revealing “lucky mutations” and new axes of biosocial commonality and difference. I explore the paths families take to the clinical trial, and the “stories of waiting” they tell about their experience in it. Finally, I examine how families navigate the uncertainty and liminality of their experience as trial subjects. I discuss how the trial unsettles taken-for-granted social roles, constraining clinical relationships and leaving parents to construct the significance of an experimental treatment in the context of limited information. In so doing, parents assemble and tell “narratives of efficacy” while administering study-drug to their children, drawing on their observations and those made by others. Though parents’ narratives are often dismissed as mere anecdote, I suggest they also offer insight for developing more personalised approaches to clinical research and outcome measurement for rare diseases, by restoring focus on the nuance, idiosyncrasy, and context of families’ experiences with investigational treatments.
Slow Manifolds for Multi-Time-Scale Stochastic Evolutionary Systems
Creators: name: Fu, Hongbo
name: Liu, Xianming
name: Duan, Jinqiao
Publisher: name: arXiv
Year: 2012
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60H15, 37L55, 37L25

description: This article deals with invariant manifolds for infinite dimensional random dynamical systems with different time scales. Such a random system is generated by a coupled system of fast-slow stochastic evolutionary equations. Under suitable conditions, it is proved that an exponentially tracking random invariant manifold exists, eliminating the fast motion for this coupled system. It is further shown that if the scaling parameter tends to zero, the invariant manifold tends to a slow manifold which captures long time dynamics. As examples the results are applied to a few systems of coupled parabolic-hyperbolic partial differential equations, coupled parabolic partial differential-ordinary differential equations, and coupled hyperbolic-hyperbolic partial differential equations.
Computational investigations of divalent heavy metal ion homeostasis
Creators: name: Rozycki, Torsten
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2009
Subjects: subject: Online-Publikation
subject: Hochschulschrift
subject: 571.752933
subject: 570

description: Die Genomsequenz des β-Proteobakteriums Cupriavidus metallidurans CH34 wurde mit denen einiger nah verwandter Proteobakterien verglichen. Viele wichtige Transportproteine, die für die Aufnahme von Nährstoffen oder essentiellen Kationen zuständig sind und auch viele essentielle Schwermetallentgiftungssysteme sind in den untersuchten Proteobakterien offenbar sehr weit verbreitet. Durch eine schrittweise evolutionäre Anpassung bestimmter Schwermetallresistenzdeterminanten ist C. metallidurans CH34 jedoch speziell an stark schwermetallbelastete Standorte angepaßt. Dabei beruht die ungewöhnliche genomische Flexibilität vieler entsprechender plasmidcodierter Determinanten auf stammspezifischen Genduplikationen und horizontalem Gentransfer. Viele plasmidständige Operons codieren hier zusätzliche Transporter mit einem z.T. abweichenden evolutionären Ursprung. Als integrales Membranprotein gehört YedZ (TC 9.B.43.) in Escherichia coli einer noch weitgehend uncharakterisierten Transporterfamilie (TC-Klasse 9) an. Die Sequenzähnlichkeit von Transmembransegmenten (TMSs) in YedZ deutet auf eine intragenomische Gentriplikation hin, wobei ein 2 TMS codierendes Segment zu den insgesamt 6 Transmembransegmenten der YedZ Transporterfamilie geführt hat. Die SbtA Transporterfamilie (TC 2.A.83) ist für die unspezifische Aufnahme von Hydrogencarbonat (HCO3-) in Cyanobacterien verantwortlich und sie dienen dabei der Anreicherung von CO2 als Substrat für die Ribulose Bisphosphate Carboxylase-Oxygenase (RuBisCO). Die zehn transmembranen Segmente (TMSs) in SbtA resultieren vermutlich aus einer Genduplikation, wobei beide Hälften eine entgegengesetzte Orientierung in der Membran besitzen.
Stochastic Lagrangian footprint calculations over a surface with an abrupt change of roughness height
Creators: name: Kurbanmuradov, Orazgeldi
name: Rannik, Ullar
name: Levykin, Alexander I.
name: Sabelfeld, Karl
name: Vesala, Timo
Publisher: name: Weierstrass Institute
Year: 2003
Subjects: subject: Forest canopy
subject: Flux footprint functions
subject: surface roughness change
subject: closure model
subject: backward Lagrangian trajectories
subject: 65C05
subject: 76S05

description: Forward and backward stochastic Lagrangian trajectory simulation methods are developed to calculate the footprint and cumulative footprint functions of concentration and fluxes in the case when the ground surface has an abrupt change of the roughness height. The statistical characteristics to the stochastic model are extracted numerically from a closure model we developed for the atmospheric boundary layer. The flux footprint function is perturbed in comparison with the footprint function for surface without change in properties. The perturbation depends on the observation level as well as roughness change and distance from the observation point. It is concluded that the footprint function for horizontally homogeneous surface, widely used in estimation of sufficient fetch for measurements, can be seriously biased in many cases of practical importance.
A Note on "On the Construction of Boolean Functions with Optimal Algebraic Immunity"
Creators: name: Li, Yuan
name: Kan, Haibin
name: Kokichi, Futatsugi
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences

description: In this note, we go further on the "basis exchange" idea presented in \cite{LiNa1} by using Mobious inversion. We show that the matrix $S_1(f)S_0(f)^{-1}$ has a nice form when $f$ is chosen to be the majority function, where $S_1(f)$ is the matrix with row vectors $\upsilon_k(α)$ for all $α\in 1_f$ and $S_0(f)=S_1(f\oplus1)$. And an exact counting for Boolean functions with maximum algebraic immunity by exchanging one point in on-set with one point in off-set of the majority function is given. Furthermore, we present a necessary condition according to weight distribution for Boolean functions to achieve algebraic immunity not less than a given number.
description: This paper has been withdrawn by the author due to the quality of ideas
Dialog-Journal - am Vorbild lernen ; zur Wirkung von Modellierungstechniken auf die Entwicklung der Schriftsprache
Creators: name: Stamer, Julia
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2018
Subjects: subject: 370

description: Authentische Lese- und Schreiberfahrungen können mit Hilfe der Dialog-Journale in den Unterricht integriert werden und ermöglichen freie, private schriftliche Dialoge. Anknüpfend an dieses interaktive Lernarrangement zeigt die vorliegende Dissertation, wie eine Förderung der Orthographie mittels der Modellierungstechniken aussehen kann und visualisiert die individuellen Lernwege der Schüler, interpretiert diese und setzt sie zur schriftsprachlichen Ausgangslage in Beziehung. Für die Untersuchung wurden neun 3. Klassen zweier Sprachheilschulen durch Randomisierung zufällig einer Interventions- und Kontrollgruppe zugewiesen. Alle 85 Sprachheilschüler schrieben über ein halbes Jahr zweimal wöchentlich Dialog-Journale, wobei in der Interventionsgruppe zusätzlich drei orthographische Regelhaftigkeiten mit steigender Intensität modelliert wurden. Die Resultate aus dem Prä- und Posttest verdeutlichen keine generalisierbaren Unterschiede in den schriftsprachlichen Leistungen. Jedoch konnte gezeigt werden, dass die Schüler in den modellierten Dialog-Journalen die Zielstrukturen signifikant häufiger richtig verwenden, ohne dass die Eintragslänge beeinflusst wurde.
description: The integration of authentic reading and writing experiences through the use of Dialogue Journals make the writing of free and private written dialogues possible in every German lesson. The present investigation is based on this kind of interactive learning process. In it, the author demonstrates how a structured feedback approach in a conversational setting may be used to modify students´ writing. Students individual learning trajectories are presented, interpreted, and compared to initial writing performance. Students from nine third-grade classes at two schools for students with speech/language problems were randomly selected and assigned as experimental and control groups. Over a period of six month, all 85 students wrote in dialogue journals twice a week. With students in the experimental group, the investigator modelled three orthographic rules at increasing levels of intensity. The results from the pre- and post-tests reveal that while it is not possible to generalize the learning of these rules in overall writing performance, students in the experimental group used the target structures significantly more frequently without affecting entry length.
Identifizierung und funktionale Charakterisierung von Komponenten der Bs4-vermittelten Resistenz
Creators: name: Strauß, Annett
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2010
Subjects: subject: Online-Publikation
subject: Hochschulschrift
subject: 571

description: Das TIR-NBS-LRR-Protein Bs4 aus Tomate vermittelt Resistenz gegenüber Xanthomonas campestris pv. vesicatoria-Stämmen, die das Avirulenzprotein AvrBs4 translozieren. Um die molekularen Mechanismen der Bs4-vermittelten Resistenz aufzuklären, wurden im Rahmen dieser Arbeit Hefe-Dihybrid-Sichtungen zur Identifizierung Bs4-assoziierter Proteine durchgeführt. Dabei wurde ein Hitzeschockprotein der Hsp70-Familie als Bs4-Interaktor isoliert. Des Weiteren konnte eine Assoziation von Bs4 mit der Serin/Threonin-Phosphatase 5 (PP5) nachgewiesen werden. PP5 wiederum interagiert mit Hsp90, was nahe legt, dass Bs4, PP5 und Hsp90 in einem Komplex in planta vorliegen. Um Signalkomponenten der Bs4-vermittelten HR zu identifizieren, wurden cDNA-Fragmente einer Tomaten-Bibliothek unter Kontrolle des 35S-Promotors zusammen mit Bs4 und avrBs4 in Nicotiana benthamiana koexprimiert. Dabei resultierte die Koexpression einer Zellulosesynthase bzw. eines Hsp70-Gens in einer verstärkten Bs4-HR.
Curvature of quantum rings
Creators: name: Jonckheere, Edmond
name: Langbein, Frank
name: Schirmer, Sophie
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mathematical Physics (math-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We develop a geometric approach to spin networks with Heisenberg or XX coupling. Geometry is acquired by defining a distance on the discrete set of spins. The key feature of the geometry of such networks is their Gauss curvature $κ$, viewed here as the ability to isometrically embed the chain in the standard Riemannian manifold of curvature $κ$. Here we focus on spin rings. Even though their visual geometry is trivial, it turns out that the geometry they acquire from the quantum mechanical distance is far from trivial.
description: Communications, Control and Signal Processing (ISCCSP), 2012, 5th International Conference of (Rome, 2012)
Funktionelle Charakterisierung der konservierten Komponenten HrcN und HrcU des Typ III-Sekretionssystems von Xanthomonas campestris pv. vesicatoria
Creators: name: Lorenz, Christian
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2009
Subjects: subject: Online-Publikation
subject: Hochschulschrift
subject: 571.9933123952
subject: 570

description: Das Gram-negative Bakterium Xanthomonas campestris pv. vesicatoria ist der Erreger der bakteriellen Fleckenkrankheit bei Paprika und Tomate. Für die Pathogenität von X. campestris pv. vesicatoria ist ein Typ III-Sekretionssystem (T3S-System) essentiell, das sowohl die Proteinsekretion in das extrazelluläre Milieu als auch die Translokation von Effektorproteinen in die pflanzliche Wirtszelle ermöglicht. In dieser Arbeit wurden die konservierten Komponenten HrcN und HrcU des T3S-Systems von X. campestris pv. vesicatoria funktionell charakterisiert. HrcN ist eine funktionale ATPase, die für die bakterielle Pathogenität essentiell ist. HrcU, dessen C-terminale cytoplasmatische proteolytisch gespalten wird, ist an der Regulation der Substratspezifität des T3S-Systems beteiligt.
Einfluss von Staphylococcus aureus α-Toxin auf die Funktion und Signaltransduktion humaner Thrombozyten
Creators: name: Vogel, Katrin
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2015
Subjects: subject: Online-Publikation
subject: Hochschulschrift
subject: 611

description: Das α-Toxin (α-Hämolysin) aus Staphylococcus aureus ist ein häufiger Infektionserreger beim Menschen. Alpha-Toxin bewirkt konzentrationsabhängig die Aggregation von Thrombozyten, die Freisetzung von Granulainhaltsstoffen aus Thrombozyten, die Aktivierung der Tyrosinkinase Src, sowie der stressinduzierten MAPKinasen p38 und JNK1/2. Src, die häufigste zelluläre Tyrosinkinase in Thrombozyten, stand dabei im Mittelpunkt unserer Untersuchungen. Nach Aktivierung der Thrombozyten durch α-Toxin wird Src durch die Kalzium-abhängige Protease Calpain degradiert und kann demnach durch Reduktion der Konzentration von extrazellulärem Kalzium oder durch den Calpaininhibitor Calpeptin gehemmt werden. Inhibitoren der Familie der Src-Kinasen wie PP1, PP2, SU6656 und Dasatinib hemmen die α-Toxin-induzierte Aktivierung der stressinduzierten MAPKinasen p38 und JNK1/2 und die Tyrosinphosphorylierung. Der Tyrosinphosphorylierung einer Reihe von Proteinen folgt konzentrationsabhängig eine rasche, nahezu vollständige Dephosphorylierung.
description: A major virulence factor in the pathogenesis of Staphylococcus aureus infection is α-toxin (also denoted as α-hemolysin). Staphylococcal α-toxin induces aggregation of platelets in a concentration-dependent manner, secretion of platelet contents, activation of tyrosine kinase Src as well as activation of the two stress-activated MAPkinases p38 and JNK1/2. Regarding individual protein kinases, the most abundant cellular tyrosine kinase Src becomes proteolytically cleaved to degradation products typical for the calcium-dependent protease calpain. The cleavage of Src can be blocked with the calpactin inhibitor calpeptin or by depletion of extracellular calcium. Pre-incubation of platelets with inhibitors of the Src tyrosine kinase family PP1, PP2, SU6654 and dasatinib leads to reduced activation of the two stress-activated MAPkinases p38 and JNK1/2, as well as protein tyrosine phosphorylation. The maxima of tyrosine phosphorylation and the onset of dephosphorylation of most of the affected proteins are concentration-dependent.
Displacing Lagrangian toric fibers by extended probes
Creators: name: Abreu, Miguel
name: Borman, Matthew Strom
name: McDuff, Dusa
Publisher: name: arXiv
Year: 2012
Subjects: subject: Symplectic Geometry (math.SG)
subject: FOS: Mathematics
subject: 53D12, 14M25, 53D40

description: In this paper we introduce a new way of displacing Lagrangian fibers in toric symplectic manifolds, a generalization of McDuff's original method of probes. Extended probes are formed by deflecting one probe by another auxiliary probe. Using them, we are able to displace all fibers in Hirzebruch surfaces except those already known to be nondisplaceable, and can also displace an open dense set of fibers in the weighted projective space P(1,3,5) after resolving the singularities. We also investigate the displaceability question in sectors and their resolutions. There are still many cases in which there is an open set of fibers whose displaceability status is unknown.
description: 53 pages, 26 figures; v3: minor corrections and updated references. To appear in Algebraic & Geometric Topology
Mobilisation von CD34-positiven Blutstammzellen für die autologe Blutstammzelltransplantation - eine retrospektive Analyse
Creators: name: Schletter, Louise Margarete
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2015
Subjects: subject: Online-Publikation
subject: Hochschulschrift
subject: 611

description: Der Standard für die Apherese CD34-positiver peripherer Blutstammzellen für eine geplante Hochdosischemotherapie (HD-CT) mit autologer peripherer Blutstammzelltransplantation umfasst eine Mobilisation mit G-CSF mit oder ohne vorhergehende Chemotherapie. Angesichts der Kosten der Prozedur sowie die Verfügbarkeit neuer Mobilisationssubstanzen wie Plerixafor ist es wichtig, Risikofaktoren für einen Apheresemisserfolg vorherzusagen. Diese retrospektive Studie analysiert dazu eine große Fallzahl von 337 Patienten, welche monozentrisch zwischen 1996 und 2008 zur geplanten HD-CT vorgestellt wurden. Von diesen wurden 465 Mobilisationsversuche inklusive 128 Remobilisationsversuche eingeschlossen. Als Apheresemisserfolg wurde die Apherese von < 2x106 CD34+-Zellen/kg KG gewertet. Die Ergebnisse zeigen, dass intensive Vortherapie mit Apheresemisserfolg assoziiert ist. Die Studie unterstützt die Strategie Plerixafor bei peripheren CD34-Werten < 20/µl am geplanten Apheresetag einzusetzen.
description: The standard for harvest of CD34-positive autologous blood stem cells for planned high dose chemotherapy (HD-CTx) with autologous blood stem cell transplantation comprises mobilization with G-CSF with or without preceding chemotherapy. Given the costs of the procedure and the option to rescue failing mobilization with new agents as plerixafor, prediction of risk factor of apheresis failure are needed. This retrospective study contributes by reporting a large series of 337 adult patients undergoing mobilization for planned HD-CTx at our center between 1996 and 2008. From these, data of 465 mobilization attempts were evaluated including 126 attempts of remobilization due to various reasons. Apheresis was regarded as failure if < 2x106 CD34+/kgBW was achieved. The results of this analysis confirmed that extended previous therapy is associated with apheresis failure. It also supports a strategy to add plerixafor if the peripheral blood CD34 count is < 20/µl on the predicted apheresis day.
Additional file 2 of Plasmodium vivax HAP2/GCS1 gene exhibits limited genetic diversity among parasite isolates from the Greater Mekong Subregion
Creators: name: Li, Danni
name: Yu, Chunyun
name: Guo, Jian
name: Wang, Yazhou
name: Zhao, Yan
name: Wang, Lin
name: Soe, Myat Thu
name: Feng, Hui
name: Kyaw, Myat Phone
name: Sattabongkot, Jetsumon
name: Jiang, Lubin
name: Cui, Liwang
name: Zhu, Xiaotong
name: Cao, Yaming
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Table S1. List of the primers along with their nucleotide sequences used to assess the genetic diversity of the pvhap2 gene.
title: β1-Integrin-vermittelte Tumor-Stroma-Interaktionen im kolorektalen Karzinom
title: BetaEins-Integrin-vermittelte Tumor-Stroma-Interaktionen im kolorektalen Karzinom
titleType: AlternativeTitle
Creators: name: Widder, Miriam
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2015
Subjects: subject: Online-Publikation
subject: Hochschulschrift
subject: 615

description: Die vorliegende Arbeit liefert neue Einblicke in die komplexen Tumor-Stroma-Interaktionen im kolorektalen Karzinom (CRC): erstmals wurde gezeigt, dass humane multipotente Stromazellen (MSC) des Knochenmarks spezifisch gegenüber anderen Stromazellen das Xenograftwachstum verschiedener CRC-Zelllinien fördern. Diese Wachstumsförderung manifestierte sich bereits in einer frühen Phase der Xenograftentwicklung und äußerte sich prominent in E-Cadherin dysfunktionalen CRC-Zellen. Im in vitro 3D-Modellwurde ermittelt, dass E-Cadherin dysfunktionale CRC-Zellen und MSC über CRC- sowie MSC-exprimiertes β1-Integrin - vermutlich mit MSC-sezerniertem Kollagen I als Linker - interagieren, wodurch der Aufbau einer Sphäroidstruktur vermittelt wird. In vivo wurde gezeigt, dass die Interaktion über CRC-exprimiertes β1-Integrin spezifisch in α-Catenin defizienten CRC-Zellen für die MSC-vermittelte Förderung des Xenograftwachstums relevant ist und somit als mögliches Therapieziel dienen könnte.
description: This PhD thesis gives new insights into the complex tumor-stroma-interactions in colorectal carcinomas (CRC): Forthe first time it could be shown thathuman bone-marrow derived multipotent stromal cells (MSC)specifically compared to other stroma cells promote xenograft growth of various CRC-cell lines. This growth-promotion already appeared during an early stage of xenograft development and was prominent for E-cadherin dysfunctional CRC-cells. Within the in vitro 3D-model, it was shown that E-cadherin dysfunctional CRC-cells and MSC interact through CRC- and MSC-expressed β1-integrin - probably with MSC-expressed collagen I as a linker - leading to the formation of a spheroid-structure. In vivo, CRC-expressed β1-integrin is involved in MSC-mediated promotion of xenograft growth specifically in α-catenin deficient CRC-cells and therefore could be used as a potential target for a therapy.
Additional file 8: of MicroRNA-374a, -4680, and -133b suppress cell proliferation through the regulation of genes associated with human cleft palate in cultured human palate cells
Creators: name: Suzuki, Akiko
name: Li, Aimin
name: Gajera, Mona
name: Abdallah, Nada
name: Zhang, Musi
name: Zhao, Zhongming
name: Iwata, Junichi
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Table S8. Transfection efficiency of miRNA mimic and inhibitor. (PDF 51 kb)
Interaktion zweier Signalwege in Granulosazellen - Wechselwirkung des Arylhydrocarbon-Rezeptors (AhR) und der Peroxisomen-Proliferator-aktivierten Rezeptoren (PPAR) in der humanen Granulosazelllinie KGN
Creators: name: Jann, Johann-Christoph
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2016
Subjects: subject: 611

description: Umweltkontaminanten vermitteln über Transkriptionsfaktoren wie den Arylhydrocarbon Rezeptor (AhR) und die Peroxisome Proliferator-aktivierten Rezeptoren (PPAR) negative Einflüssen auf das reproduktive System. Ziel dieser Arbeit war es den Einfluss von Tetrachlorodibenzo-p-dioxin (TCDD, ein AhRLigand) und Di-ethylhexyl-phthalat (DEHP, ein PPAR Ligand), auf die Gonadotropin Sensitivität und Estrogensynthese in der humanen Granulosazelllinie KGN zu untersuchen. MEHP, der aktive Ligand von DEHP akkumuliert in KGN Zellen, was die Metabolisierung von DEHP belegt. Eine funktionelle Signalkaskade der PPARs wurde durch Rosiglitazon und Bezafibrat gezeigt. KGN Zellen wurden mit TCDD, DEHP oder beidem exponiert und mittels ELISA, qRT-PCR und Western Blot analysiert. Die Exposition mit TCDD, DEHP und dem Mix reduzierte die Estradiolsynthese und die Expression des FSH-R, DEHP jedoch erhöhte die Expression die LH-R. Diese Untersuchungen zeigen, dass Endokrine Disruptoren direkt über die Aktivierung des AhR, aber auch über Transaktivierung der PPAR die Genexpression mit weitreichenden Konsequenzen für Granulosazellfunktion verändern können.
description: Environmental contaminants binding to transcription factors, such as the aryl hydrocarbon receptor (AhR) and the peroxisome proliferator-activated receptors (PPARs), contribute to adverse effects on the reproductive system. The aim of the study was to investigate the impact of tetrachlorodibenzo-p-dioxin(TCDD, anAhRligand) and di-ethylhexyl phthalate (DEHP, a PPARligand), on gonadotrophin sensitivity and estrogen synthesis in the human granulosa cell line KGN. Accumulation of the active metabolite MEHP demonstrates DEHP metabolism in KGN cells. A functional PPAR cascade was confirmed using rosiglitazone and bezafibrate. KGN were exposed to TCDD, DEHP or a mix of both and analysed by ELISA, qRT–PCR and western blot. Exposure decreased estradiol synthesis (TCDD, DEHP, mix) and reduced the expression of aromatase and FSH-R, but LH-R expression was increased by DEHP. This demonstrates that endocrine disrupting chemicals may act by direct activation of AhR or by transactivation via PPAR inducing subsequent transcriptional changes with long lasting effects on granulosa cell function.
Shadow price in the power utility case
Creators: name: Herczegh, Attila
name: Prokaj, Vilmos
Publisher: name: arXiv
Year: 2011
Subjects: subject: Portfolio Management (q-fin.PM)
subject: Probability (math.PR)
subject: FOS: Economics and business
subject: FOS: Mathematics

description: We consider the problem of maximizing expected power utility from consumption over an infinite horizon in the Black-Scholes model with proportional transaction costs, as studied in Shreve and Soner [Ann. Appl. Probab. 4 (1994) 609-692]. Similar to Kallsen and Muhle-Karbe [Ann. Appl. Probab. 20 (2010) 1341-1358], we derive a shadow price, that is, a frictionless price process with values in the bid-ask spread which leads to the same optimal policy.
description: Published at http://dx.doi.org/10.1214/14-AAP1058 in the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Informing selective screening through more robust estimation of STI risk
Creators: name: Falasinnu, Titilola Oluwaseun
Publisher: name: University of British Columbia
Year: 2015

description: Background. Due to rising health care costs and increases in client volumes, it is imperative to develop systems that make efficient use of increasingly scarce publicly funded sexual health resources. With this in mind, an internet-based testing program that provides online access to STI testing is in development in British Columbia (BC) to improve the accessibility and limit the burden on health resources. However, much is still unknown about how to implement risk assessment and recommend tests in online settings. Prediction rules have been shown to successfully increase efficiency and cost-effectiveness of STI case finding. The aim of this dissertation was to develop and validate a risk-scoring algorithm for the selective screening of asymptomatic patients at increased risk for chlamydia and gonorrhoea infections. Methods. The risk-scoring algorithm was derived from a multivariate logistic regression of patient visits at two sexual health clinics in Vancouver between 2000 and 2006 (i.e., derivation population) and validated in a subsequent time period between 2007 and 2012 (i.e., temporal validation population). The model’s performance was evaluated using the area under the receiver operating characteristic curve (AUC) and the Hosmer-Lemeshow (H-L) statistic. Geographical validation was performed using seven sexual health clinics outside of Vancouver between 2000 and 2012. Results. The prevalence of infection was 1.8% (n=10,437), 2.2% (n=14,956), and 5.3% (n=10,425) in the derivation, temporal validation, and geographical validation populations, respectively. The predictors that comprised the algorithm were young age, non-white race/ethnicity, multiple sexual partners, previous chlamydia or gonorrhoea infection. The model discriminative accuracy was good in the derivation population (AUC=0.74, 95% CI: 0.70-0.77) and acceptable in the temporal (AUC=0.64, 95% CI: 0.61-0.67) and geographical (AUC=0.69, 95% CI: 0.67-0.71) validation populations. The model also demonstrated adequate calibration and screening performance in all three populations. Conclusions. The results from this research will have important implications for scaling up of Internet-based testing in BC. The algorithm could be adapted in an online setting to offer individualized testing recommendations and create educational materials to inform other Web-based content by creating awareness about STI risk factors, which may stimulate health care seeking behaviour among individuals accessing the website.
Holographic Jets in an Expanding Plasma
Creators: name: Stoffers, Alexander
name: Zahed, Ismail
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We use the holographic principle to study quark jets with trailing strings in an expanding plasma that asymptotes Bjorken hydrodynamics. We make use of the fact that the trailing string is the locus of the light delay in bulk to obtain the explicit form for quark jets in the expanding plasma. From the trailing string solution we calculate the drag coefficient of a heavy quark in the strongly coupled expanding plasma. The energy scaling of the maximum penetration length of an ultrarelativistic light quark jet using light rays in bulk is estimated.
Beeinflussung der Herzregeneration im Mausmodell durch Inhibierung von p53-abhängigen Signalkaskaden
Creators: name: Greye, Katharina
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2015
Subjects: subject: 611

description: In dieser Arbeit sollen in einem in-vivo-Experiment an adulten Mäusen die Effekte des synthetischen p53-Hemmers Pifithrin-α (PFT-α) auf das Postinfarkt-Remodeling und sein Einfluss auf die Apoptose und den Zellzyklus der Zellen des Herzmuskelgewebes nach einem Myokardinfarkt genauer untersucht werden. Dazu werden durch einen operativen Verschluss der linken Herzkranzarterie Myokardinfarkte induziert, und im Anschluss wird PFT-α über 6d intraperitoneal injiziert. Die Untersuchungen zeigen im Beobachtungszeitraum signifikant geringere Überlebensraten der mit PFT-α in einer Dosierung von 4,4 μg/g behandelten Versuchstiere, wobei Herzrupturen die Haupttodesursache darstellen. Die Gabe von PFT-α verschlechtert außerdem die Herzfunktion und führt zu einer signifikanten Zunahme der Infarktausdehnung. Zudem verringert PFT-α die Replikationsraten der Nicht-Muskelzellen im Infarktgebiet. Zusammenfassend kann festgestellt werden, dass die Gabe von PFT-α nach akutem Myokardinfakt im Mausmodell zu einer Destabilisierung der sich entwickelnden Narbe und damit dem vermehrten Auftreten von Herzrupturen führt.
description: This work uses an in-vivo experiment of adult mice to examine the effects of the p53 inhibitor pifithrin- α (PFT-α) on remodeling after myocardial infarction and its influence on apoptosis and cell cycle of heart tissue after myocardial infarction. For this purpose myocardial infarcts are generated by an operative ligation of left coronary artery followed by intraperitoneal injection of PFT-α over a period of 6 days. The experiments result in a significant reduction of survival rates of mice which get PFT-α in a high dose (4,4 μg/g), with myocardial rupture being the main cause of death. Furthermore, the administration of pifithrin-α deteriorates heart function and leads to a significant increase of infarct extension. PFT- reduces the replication rate of non-cardiomyocytes in the infarct area. In summary, in the mouse model the application of PFT- after acute myocardial infarction leads to a destabilization of infarction scar followed by an increased rate of cardial rupture.