cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 2 of Plasma campesterol and ABCG5/ABCG8 gene loci on the risk of cholelithiasis and cholecystitis: evidence from Mendelian randomization and colocalization analyses
Creators: name: Mi, Jiarui
name: Jiang, Qingwei
name: Qi, Zhengwei
name: Liu, Zhengye
name: Bai, Xiaoyin
name: Zheng, Xia
name: Wu, Jiaguo
name: Fang, Yanfei
name: Yang, Aiming
name: Chen, Haotian
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Plant Biology

description: Additional file 2: Fig. S2 Heatmap showing the causal estimates of metabolites (with only 1 SNP as valid instrumental variable) on the risk of cholelithiasis and cholecystitis. The p-value is adjusted using Bonferroni method. R9, FinnGen Release 9; UKBB, UK Biobank
Singularity of super-Brownian local time at a point catalyst.
Creators: name: Dawson, Donald A.
name: Fleischmann, Klaus
name: Li, Yi
name: Müller, Carl
Publisher: name: Weierstrass Institute
Year: 1993
Subjects: subject: Point catalytic medium
subject: critical branching
subject: super-Brownian local time
subject: occupation time
subject: occupation density
subject: measure-valued branching
subject: superprocess
subject: 60J80
subject: 60J65
subject: 60G57

description: In a one-dimensional single point-catalytic continuous super-Brownian motion studied by Dawson and Fleischmann (1993), the occupation density measure λc at the catalyst's position c is shown to be a singular (diffuse) random measure. The source of this qualitative new effect is the irregularity of the varying medium δc describing the point catalyst. The proof is based on a probabilistic characterization of the law of the Palm canonical clusters χ appearing in the Lévy-Khinchin representation of λc in a historical process setting and the fact that these χ have infinite left upper density (with respect to Lebesgue measure) at the Palm time point.
Improved Thermal Stability of Cesium-Doped Perovskite Films With PMMA for Solar Cell Application
Creators: name: Gausin, Christine M.
Publisher: name: Old Dominion University Libraries
Year: 2018

description: Perovskite solar cells (PSCs) have the potential to replace the traditional silicon solar cells for commercialization applications. Perovskites offer a lower cost to fabrication, superb efficiencies, high absorption coefficients, longer carrier lifetime and diffusion lengths. Despite their improved efficiency, perovskites suffer from several degradations relating to the material’s organic-inorganic composition upon exposure to different environmental conditions. In general, the main causes of degradation of perovskite films are due to exposure to moisture, oxygen, air, light, and temperature. Several efforts have been made to stabilize perovskites including encapsulation, doping of cations, and alterations to the perovskite structure. In this work, we study the effect of PMMA and cesium (Cs) on the thermal stability of perovskite solar cells.

Due to the organic composition of perovskite solar cells (PSCs), the material has high sensitivity to moisture, air, oxygen, light and heat. Upon exposure to these sensitive factors, perovskite films undergo degradation very quickly, resulting in a reduced efficiency and unstable cell. To better improve the material’s stability, we study the effect of adding a PMMA layer on top of the MAPbI3 samples, induced at 85°C to study whether PMMA has a major effect not only in protecting the layer from degradation factors, but also on its thermal stability. XRD measurements confirmed that samples without the PMMA layer quickly showed signs of degradation after 72 hours of heating with the peak formation of PbI2. MAPbI3 samples with the PMMA were able to withstand heating up to 1000 hours with minor sign of the PbI2 peak. SEM images confirmed the degradation of the samples without PMMA as indicated by pinholes forming along the grain boundaries and grain of the samples, while samples with the PMMA showed very little signs of degradation.

We further studied the thermal stability of perovskite solar cells by heating the samples at a more aggressive temperature (120°C) and study the effects of cesium on the precursor solution. Due to MAPbI3’s susceptibility to degradation at higher temperatures, cesium was added to the precursor solution at different concentrations (x = 5, 9 and 20%) to form the CsxMA1−xPbI3 formula. XRD data showed that after 72 hours of thermal treatment, samples with the cesium content withheld the perovskite samples from complete degradation. Data for the MAPbI3 reference sample showed complete degradation after the 72 hours, as indicated by the very intense peak formation of PbI2.
Additional file 3 of Plasma campesterol and ABCG5/ABCG8 gene loci on the risk of cholelithiasis and cholecystitis: evidence from Mendelian randomization and colocalization analyses
Creators: name: Mi, Jiarui
name: Jiang, Qingwei
name: Qi, Zhengwei
name: Liu, Zhengye
name: Bai, Xiaoyin
name: Zheng, Xia
name: Wu, Jiaguo
name: Fang, Yanfei
name: Yang, Aiming
name: Chen, Haotian
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Plant Biology

description: Additional file 3: Fig. S3 Heatmap showing the causal estimates of metabolites on the risk of cholelithiasis and cholecystitis using weighted-median model. The p-value is adjusted using Bonferroni method. R9, FinnGen Release 9; UKBB, UK Biobank )
Asking and Answering Questions: ADW’s Flexible Querying Tool
Creators: name: Dewey, Tanya
name: Myers, Phil
name: Espinosa, Roger
name: Jones, Tricia
name: Hammond, George
Publisher: name: QUBES
Year: 2017

description: Presentation made by Tanya Dewey et al. as part of the "Bringing Research Data to the Ecology Classroom: Opportunities, Barriers, and Next Steps” Session at the Ecological Society of America annual meeting, August 8th, 2017, Portland Oregon.
MPEC 2024-W56 : 2024 WU
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 WU

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Additional file 4 of Plasma campesterol and ABCG5/ABCG8 gene loci on the risk of cholelithiasis and cholecystitis: evidence from Mendelian randomization and colocalization analyses
Creators: name: Mi, Jiarui
name: Jiang, Qingwei
name: Qi, Zhengwei
name: Liu, Zhengye
name: Bai, Xiaoyin
name: Zheng, Xia
name: Wu, Jiaguo
name: Fang, Yanfei
name: Yang, Aiming
name: Chen, Haotian
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Plant Biology

description: Additional file 4. Fig. S4 Heatmap showing the causal estimates of metabolites on the risk of cholelithiasis and cholecystitis using MR-egger method. The p-value is not adjusted for multiple testing. R9, FinnGen Release 9; UKBB, UK Biobank
title: Anton Cechov und Mark Aurel
Creators: name: Sonnleitner, Julia Cornelia Gabriella
Year: 2008

description: In dieser Arbeit wird der literarischen Beziehung Cechovs zu Mark Aurel nachgegangen. Dabei werden die verschiedenen Lesarten Cechovs der stoischen Philosophie anhand von drei Erzählungen nachvollzogen. Im ersten Teil wird die Bedeutung der Stoa und Mark Aurels für Cechovs Biografie dargestellt, im zweiten Teil werden die drei Erzählungen analysiert und im Schluss die theoretische Anknüpfung an die Intertextualtiät gesucht.
Construction and characterization of a recombinant yellow fever virus expressing a fragment of SIV Gag protein (MiniGene SIVGag45-269 )
Creators: name: Santana, Marlon G.V.
name: Neves, Patricia C.F.
name: Santos, Juliana Ribeiro Dos
name: D.I. Watkins
name: Galler, Ricardo
name: Bonaldo, Myrna C.
Publisher: name: F1000Research
Year: 2017

description: Yellow fever vaccine 17D is considered to be one of the most successful vaccines available. The molecular basis of this effective immune response is related to the ability of YF-17D to activate to stimulate polyvalent immunity. These outstanding properties have led to the concept to engineer the 17D virus to express heterologous antigens in order to develop new recombinant human vaccines. Here, we have employed a previously described approach (Virol J 2007, 4, 11534) to construct a viable, and immunogenic recombinant yellow fever 17D viruses expressing a fragment of SIV (“Simian Immunodeficiency Virus) gag protein encompassing the residues 45 to 269, which was called rYF17D/SIVGag45-269 virus.
Acculturation and Enculturation, Perception of Depressive Symptoms, and Help-Seeking Behaviors among Korean Americans
Creators: name: Park, Kristoffer
Publisher: name: Old Dominion University Libraries
Year: 2016

description: The literature suggests that acculturation, enculturation, and the perception of mental health symptoms are some of the factors that explain help-seeking behaviors in Asian Americans. While there has been previous research addressing these concerns for Asian Americans as a unified ethnic group, few studies have examined these factors to explain help-seeking behaviors specifically in Korean Americans. 107 Korean Americans were recruited from Korean American churches in a large metropolitan city in the southeast region. Participants completed an online questionnaire, which included instruments assessing acculturation (AVS-R) and enculturation (EAVS-AA-R) levels as well as their perception of how problematic depressive symptoms were and willingness to seek help. The findings indicated that acculturation was significantly related to greater willingness to seek help from a psychologist for depressive symptoms and enculturation was significantly related to lower willingness to seek a psychologist for help with depressive symptoms. The results also showed that acculturation was significantly related to a greater likelihood of perceiving affective depressive symptoms as problematic. Lastly, the findings revealed that perceiving affective symptoms as problematic mediated the relationship between acculturation and willingness to seek help from a psychologist. These findings both compliment and contradict previous studies of acculturation, enculturation, perception of depressive symptoms, and help-seeking behaviors among Korean Americans.
sj-docx-1-taw-10.1177_20420986221135931 – Supplemental material for Risk of venous thromboembolism among women receiving ospemifene: a comparative observational study
Creators: name: Nordstrom, Beth L.
name: Cai, Bin
name: De Gregorio, Fabio
name: Ban, Lu
name: Fraeman, Kathy H.
name: Yoshida, Yuki
name: Gibbs, Trevor
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: FOS: Clinical medicine
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified

description: Supplemental material, sj-docx-1-taw-10.1177_20420986221135931 for Risk of venous thromboembolism among women receiving ospemifene: a comparative observational study by Beth L. Nordstrom, Bin Cai, Fabio De Gregorio, Lu Ban, Kathy H. Fraeman, Yuki Yoshida and Trevor Gibbs in Therapeutic Advances in Drug Safety
Additional file 1 of Dendritic cells under allergic condition enhance the activation of pruritogen-responsive neurons via inducing itch receptors in a co-culture study
Creators: name: Singto, Tichakorn
name: Filor, Viviane
name: Vidak, Jonathan
name: Klopfleisch, Robert
name: Bäumer, Wolfgang
Publisher: name: figshare
Year: 2024
Subjects: subject: Cell Biology
subject: Neuroscience
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Supplementary Material 1
MSW-Net: A hierarchical stacking model for automated municipal solid waste classification
Creators: name: Jayaraman, Vaishnavi
name: Lakshminarayanan, Arun Raj
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Space Science
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Science Policy

description: Efficient solid waste management is crucial for urban health and welfare in the midst of fast industrialization and urbanization. In this changing environment, government authorities have a significant role in addressing and reducing the effects of solid waste. While waste separation at the source simplifies processes, manual sorting is a consequence of ignorance in numerous regions, which endangers the health of waste pickers. This study addresses the challenges by introducing the MSW-Net model, a hierarchical stacking model designed for the automated classification of municipal solid waste (MSW). Customized Convolutional Neural Network (custom CNN) and Bayesian-Optimized MobileNet models serve as the base models, with Gradient Boosting employed as the meta-classifier. The MSW-Net model, as proposed, exhibits exceptional performance, attaining 99%, 95%, and 96.43% accuracy rates over training, validation, and testing, respectively. Additionally, the model achieves precision, recall, and F1 scores of 96.42%, 96.43%, and 96.42% during the testing phase. Therefore, the proposed MSW-Net model performs better than the other existing models in sorting the waste. This could also aid the municipal authorities in classifying the waste with minimal human intervention. Implications: The MSW-Net model, featuring a hierarchical stacking approach with custom CNN and Bayesian-Optimized MobileNet base models, and Gradient Boosting as the meta-classifier, achieves remarkable accuracy in automated municipal solid waste classification. With performance metrics of 99% accuracy in training, 95% in validation, and 96.43% in testing, alongside precision, recall, and F1 scores around 96.42%, the MSW-Net model significantly outperforms existing models. This advancement promises to aid municipal authorities in efficient waste management, reducing reliance on manual sorting and thereby improving the health and safety of waste pickers.
sj-docx-4-ggm-10.1177_23337214231174129 – Supplemental material for Loneliness and Mental Health in Response to Early and Late COVID-19 Outbreak: A Cross-Sectional Study of Czech Adults Aged 50 and Over
Creators: name: Vaculíková, Jitka
name: Hanková, Magdalena
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine

description: Supplemental material, sj-docx-4-ggm-10.1177_23337214231174129 for Loneliness and Mental Health in Response to Early and Late COVID-19 Outbreak: A Cross-Sectional Study of Czech Adults Aged 50 and Over by Jitka Vaculíková and Magdalena Hanková in Gerontology and Geriatric Medicine
A high-performance pipeline for differential methylation analysis
Creators: name: Riva, Alberto
name: Rosha Poudyal
name: Ianov, Lara
name: Tongjun Gu
name: Kladde, Michael
name: Foster, Thomas
Publisher: name: F1000Research
Year: 2017

description: DMAP is a comprehensive pipeline for the differential analysis of methylation from high-throughput sequencing of sodium-bisulfite converted DNA. Its main features include: flexibility in the specification of the methylated sites, ability to evaluate methylation changes across multiple conditions, and ease of configuration.

DMAP is based on the MOABS pipeline [1], but replaces its MCALL module, responsible for identifying base conversions and computing methylation rates, with the new tool CSCALL [2]. CSCALL uses samtools to determine coverage and conversion rates at each site of interest, resulting in fast and reliable processing, and is able to examine conversion of cytosine in contexts other than CG, whose importance in plants and mammalian embryonic stem cells is increasingly recognized.

The main CSCALL output is a BED file containing coverage and conversion rates at each analyzed site; the program also generates a report of coverage and conversion rates (by chromosome and genomewide), and reports conversion rates for "lone" cytosines, an important quality control measure. Finally, CSCALL provides a filtering function that can be applied to short reads before the mapping step, which removes reads with an excessive number of unconverted lone cytosines.

DMAP output consists of an automatically-generated report including tables of differentially methylated sites between conditions, plots of methylation across chromosomes and gene regions, and quality control statistics. Usage of the pipeline is controlled by a simple configuration file listing input files for each sample and all experimental conditions.
MSW-Net: A hierarchical stacking Model for automated municipal solid waste classification
Creators: name: Jayaraman, Vaishnavi
name: Lakshminarayanan, Arun Raj
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Space Science
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Science Policy

description: Efficient solid waste management is crucial for urban health and welfare in the midst of fast industrialization and urbanization. In this changing environment, government authorities have a significant role in addressing and reducing the effects of solid waste. While waste separation at the source simplifies processes, manual sorting is a consequence of ignorance in numerous regions, which endangers the health of waste pickers. This study addresses the challenges by introducing the MSW-Net model, a hierarchical stacking model designed for the automated classification of municipal solid waste (MSW). Customized Convolutional Neural Network (custom CNN) and Bayesian-Optimized MobileNet models serve as the base models, with Gradient Boosting employed as the meta-classifier. The MSW-Net model, as proposed, exhibits exceptional performance, attaining 99%, 95%, and 96.43% accuracy rates over training, validation, and testing, respectively. Additionally, the model achieves precision, recall, and F1 scores of 96.42%, 96.43%, and 96.42% during the testing phase. Therefore, the proposed MSW-Net model performs better than the other existing models in sorting the waste. This could also aid the municipal authorities in classifying the waste with minimal human intervention. Implications: The MSW-Net model, featuring a hierarchical stacking approach with custom CNN and Bayesian-Optimized MobileNet base models, and Gradient Boosting as the meta-classifier, achieves remarkable accuracy in automated municipal solid waste classification. With performance metrics of 99% accuracy in training, 95% in validation, and 96.43% in testing, alongside precision, recall, and F1 scores around 96.42%, the MSW-Net model significantly outperforms existing models. This advancement promises to aid municipal authorities in efficient waste management, reducing reliance on manual sorting and thereby improving the health and safety of waste pickers.
Militarized elections and citizens’ support for democratic rights: evidence from India
Creators: name: Deglow, Annekatrin
name: Fjelde, Hanne
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: Mental Health

description: Across the world, many citizens go to the polls amidst armed threats from both state and non-state actors. How do militarized elections affect citizens’ willingness to accept restrictions on democratic rights? We argue that when forming opinions about appropriate limits to state powers, citizens navigate competing threats from state and non-state actors. The display of state coercive force should make citizens more protective of civil and political rights. Yet, if it occurs in the context of threat posed by non-state actors, citizens may become more likely to accept that rights are restricted. We embed a vignette experiment with a selective information prime in a 2019 post-election survey of 1,080 Indian citizens across two states affected by armed insurgency. We find that being primed on a heavy state-military presence makes citizens more reluctant to accept restrictions on civil and political rights, but the effect is only found among politically marginalized groups. In the presence of violent non-state threats, however, citizens become more likely to support policies that curtail democratic rights.
NGL – a molecular graphics library for the web
Creators: name: Rose, Alexander S.
name: Burley, Stephen K.
Publisher: name: F1000Research
Year: 2017

description: Interactive visualization and annotation of large macromolecular complexes on the web is becoming a challenging problem as experimental techniques advance at an unprecedented rate. Integrative/Hybrid approaches are increasing being used to determine 3D structures of biological macromolecules by combining information from X-ray crystallography, NMR spectroscopy, and cryo-electron microscopy with data from diverse complementary experimental and computational methods. The wealth, size and complexity of available and future structures make scalable visualization and annotation solutions more important than ever. The web can provide easy access to the resulting visualizations for all interested parties, including colleagues, collaborators, reviewers and educators. Herein, we utilize the web-based NGL library to provide 3D visualization of experimental and computational data integrated with general molecular graphics.

The NGL library has a versatile API to control every aspect from data loading, processing and rendering. A distinguishing feature of NGL is its scalability to system with a million atoms and more. Further, the library supports many file formats for small molecules, macromolecular structures, molecular dynamics trajectories, maps for crystallographic, microscopy and general purpose volumetric data. Annotations can be loaded from text, json, msgpack or xml files. A wide array of customizable representations is available. Molecular data can be displayed as balls, sticks, cartoons, surfaces and labels or with specialized representations such as hyperballs and ropes. Volumetric data can be rendered as isosurfaces, point clouds or volume slices. Additional file parsers and data representations can be added through a plugin system.

The NGL library allows developers to create custom visualization solutions for specialized or novel 3D data derived from bioinformatics calculations and biophysical/biochemical experiments. The resulting interactive visualizations enable spatial understanding and exploratory analyses. Furthermore, these web-based tools simplify data exchange and foster collaborative analysis.
sj-docx-1-eab-10.1177_00139165231176069 – Supplemental material for Explaining Changes in Threat Appraisal, Coping Appraisal, and Flood Risk-Reducing Behavior Using Panel Data From a Nation-Wide Survey in Germany
Creators: name: Bubeck, Philip
name: Osberghaus, Daniel
name: Thieken, Annegret H.
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, sj-docx-1-eab-10.1177_00139165231176069 for Explaining Changes in Threat Appraisal, Coping Appraisal, and Flood Risk-Reducing Behavior Using Panel Data From a Nation-Wide Survey in Germany by Philip Bubeck, Daniel Osberghaus and Annegret H. Thieken in Environment and Behavior
Additional file 2 of Dendritic cells under allergic condition enhance the activation of pruritogen-responsive neurons via inducing itch receptors in a co-culture study
Creators: name: Singto, Tichakorn
name: Filor, Viviane
name: Vidak, Jonathan
name: Klopfleisch, Robert
name: Bäumer, Wolfgang
Publisher: name: figshare
Year: 2024
Subjects: subject: Cell Biology
subject: Neuroscience
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Supplementary Material 2
High Resolution Dune Complex Mapping for the Monitoring of Coastal Landform Change, First Landing State Park, Virginia
Creators: name: McLeod, George M.
name: Daigneau, Joe
name: Collins, James
name: Swan, Norma
name: Allen, Thomas R.
Publisher: name: Old Dominion University Libraries
Year: 2007

description: First Landing State Park is located on the southern shore of the mouth of the Chesapeake Bay. The park contains a prograding shoreline and dune complex that has been steadily growing northward. Accurate three dimensional mapping of the resident coastal dune features is challenging due to the dynamic nature of the dunescape. Precise mapping within First Landing was accomplished through careful planning, employ of advanced Global Positioning System (GPS) technology, and intensive data analysis. Mapping ensued during a period of optimal satellite signal availability and strength. Data points were collected at manual intervals with a Leica GS50+ GPS receiver, utilizing real-time kinematic (RTK) corrections from ground control stations. Vertical data accuracies of less than 5cm were achieved. Horizontal accuracies were near 1cm. The resultant data was interpolated to create realistic contour maps, triangulated irregular networks (TINS), and raster elevation models of the study area. The methods employed may be replicated at standard time intervals for the purpose of establishing a database to maintain an inventory of dune features within First Landing. Temporal changes in this inventory may be monitored to illustrate rates of change and illuminate conditions that may require management intervention.
Spautin-1 promotes PINK1-PRKN-dependent mitophagy and improves associative learning capability in an alzheimer disease animal model
Creators: name: Yi, Juan
name: Wang, He-Ling
name: Lu, Guang
name: Zhang, Hailong
name: Wang, Lina
name: Li, Zhen-Yu
name: Wang, Liming
name: Wu, Yihua
name: Xia, Dajing
name: Fang, Evandro F.
name: Shen, Han-Ming
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Spautin-1 is a well-known macroautophagy/autophagy inhibitor via suppressing the deubiquitinases USP10 and USP13 and promoting the degradation of the PIK3C3/VPS34-BECN1 complex, while its effect on selective autophagy remains poorly understood. Mitophagy is a selective form of autophagy for removal of damaged and superfluous mitochondria via the autophagy-lysosome pathway. Here, we report a surprising discovery that, while spautin-1 remains as an effective autophagy inhibitor, it promotes PINK1-PRKN-dependent mitophagy induced by mitochondrial damage agents. Mechanistically, spautin-1 facilitates the stabilization and activation of the full-length PINK1 at the outer mitochondrial membrane (OMM) via binding to components of the TOMM complex (TOMM70 and TOMM20), leading to the disruption of the mitochondrial import of PINK1 and prevention of PARL-mediated PINK1 cleavage. Moreover, spautin-1 induces neuronal mitophagy in Caenorhabditis elegans (C. elegans) in a PINK-1-PDR-1-dependent manner. Functionally, spautin-1 is capable of improving associative learning capability in an Alzheimer disease (AD) C. elegans model. In summary, we report a novel function of spautin-1 in promoting mitophagy via the PINK1-PRKN pathway. As deficiency of mitophagy is closely implicated in the pathogenesis of neurodegenerative disorders, the pro-mitophagy function of spautin-1 might suggest its therapeutic potential in neurodegenerative disorders such as AD. Abbreviations: AD, Alzheimer disease; ATG, autophagy related; BafA1, bafilomycin A1; CALCOCO2/NDP52, calcium binding and coiled-coil domain 2; CCCP, carbonyl cyanide m-chlorophenyl hydrazone; COX4/COX IV, cytochrome c oxidase subunit 4; EBSS, Earle’s balanced salt; ECAR, extracellular acidification rate; GFP, green fluorescent protein; IA, isoamyl alcohol; IMM, inner mitochondrial membrane; MAP1LC3/LC3, microtubule associated protein 1 light chain 3; MMP, mitochondrial membrane potential; mtDNA, mitochondrial DNA; nDNA, nuclear DNA; O/A, oligomycin-antimycin; OCR, oxygen consumption rate; OMM, outer mitochondrial membrane; OPTN, optineurin; PARL, presenilin associated rhomboid like; PINK1, PTEN induced kinase 1; PRKN, parkin RBR E3 ubiquitin protein ligase; p-Ser65-Ub, phosphorylation of Ub at Ser65; TIMM23, translocase of inner mitochondrial membrane 23; TOMM, translocase of outer mitochondrial membrane; USP10, ubiquitin specific peptidase 10; USP13, ubiquitin specific peptidase 13; VAL, valinomycin; YFP, yellow fluorescent protein.
Additional file 1 of Implicit and explicit: a scoping review exploring the contribution of anthropological practice in implementation science
Creators: name: Faro, Elissa Z.
name: Taber, Peter
name: Seaman, Aaron T.
name: Rubinstein, Ellen B.
name: Fix, Gemmae M.
name: Healy, Heather
name: Reisinger, Heather Schacht
Publisher: name: figshare
Year: 2024
Subjects: subject: Anthropology
subject: FOS: Sociology

description: Additional file 1: Supplemental file 1. Search Strategies. Search Strategies for PubMed, Embase, Cochrane CENTRAL, CINAHL, PsycINFO, Web of Science, and Anthropology Plus databases.
sj-docx-1-tar-10.1177_17534666231216566 – Supplemental material for Value of human epididymis secretory protein 4 in differentiating malignant from benign pleural effusion: an analysis of two cohorts
Creators: name: Yang, Qian
name: Niu, Yan
name: Wen, Jian-Xun
name: Yang, Dan-Ni
name: Han, Yu-Ling
name: Wen, Xu-Hui
name: Yan, Li
name: Huang, Jin-Hong
name: Chen, Hong
name: Zheng, Wen-Qi
name: Jiang, Ting-Wang
name: Hu, Zhi-De
Publisher: name: SAGE Journals
Year: 2023
Subjects: Aged Health Care
Pharmacology and Pharmaceutical Sciences not elsewhere classified
Respiratory Diseases

description: Supplemental material, sj-docx-1-tar-10.1177_17534666231216566 for Value of human epididymis secretory protein 4 in differentiating malignant from benign pleural effusion: an analysis of two cohorts by Qian Yang, Yan Niu, Jian-Xun Wen, Dan-Ni Yang, Yu-Ling Han, Xu-Hui Wen, Li Yan, Jin-Hong Huang, Hong Chen, Wen-Qi Zheng, Ting-Wang Jiang and Zhi-De Hu in Therapeutic Advances in Respiratory Disease
Locloud D4.2: Live Support Portal
Creators: name: Bergheim, Stein Runar
name: Angelis, Stavros
name: Makri, Dimitra-Nefeli
name: Gavrilis, Dimitris
Publisher: name: Zenodo
Year: 2014
Subjects: "LoCloud support portal"

description: The LoCloud Live Support Portal (http://support.locloud.eu) is a gateway for all components of the LoCloud support mechanism provided. The support portal gives LoCloud partners and other interested parties unrestricted public access to:

1. Descriptions of services and applications

2. Technical and end-­‐user documentation for all services and applications, and training materials

3. Frequently asked questions that are of relevance to the wider community

4. Help-­desk functionality
description: LoCloud was funded by the European Commission's ICT Policy Support Programme. Grant Agreement number: 325099
Additional file 2 of Implicit and explicit: a scoping review exploring the contribution of anthropological practice in implementation science
Creators: name: Faro, Elissa Z.
name: Taber, Peter
name: Seaman, Aaron T.
name: Rubinstein, Ellen B.
name: Fix, Gemmae M.
name: Healy, Heather
name: Reisinger, Heather Schacht
Publisher: name: figshare
Year: 2024
Subjects: subject: Anthropology
subject: FOS: Sociology

description: Additional file 2: Supplemental file 2. Abstract screening tool. Ethnography in Implementation Science Abstract Screening Inclusion Rubric for Second Round Screening.
FOXO-regulated DEAF1 controls muscle regeneration through autophagy
Creators: name: Goh, Kah Yong
name: Lee, Wen Xing
name: Choy, Sze Mun
name: Priyadarshini, Gopal Krishnan
name: Chua, Kenon
name: Tan, Qian Hui
name: Low, Shin Yi
name: San Chin, Hui
name: Wong, Chee Seng
name: Huang, Shu-Yi
name: Fu, Nai Yang
name: Nishiyama, Jun
name: Harmston, Nathan
name: Tang, Hong-Wen
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Astronomical and Space Sciences not elsewhere classified
subject: Developmental Biology
subject: Plasma Physics
subject: Computational Biology

description: The commonality between various muscle diseases is the loss of muscle mass, function, and regeneration, which severely restricts mobility and impairs the quality of life. With muscle stem cells (MuSCs) playing a key role in facilitating muscle repair, targeting regulators of muscle regeneration has been shown to be a promising therapeutic approach to repair muscles. However, the underlying molecular mechanisms driving muscle regeneration are complex and poorly understood. Here, we identified a new regulator of muscle regeneration, Deaf1 (Deformed epidermal autoregulatory factor-1) – a transcriptional factor downstream of foxo signaling. We showed that Deaf1 is transcriptionally repressed by FOXOs and that DEAF1 targets to Pik3c3 and Atg16l1 promoter regions and suppresses their expression. Deaf1 depletion therefore induces macroautophagy/autophagy, which in turn blocks MuSC survival and differentiation. In contrast, Deaf1 overexpression inactivates autophagy in MuSCs, leading to increased protein aggregation and cell death. The fact that Deaf1 depletion and its overexpression both lead to defects in muscle regeneration highlights the importance of fine tuning DEAF1-regulated autophagy during muscle regeneration. We further showed that Deaf1 expression is altered in aging and cachectic MuSCs. Manipulation of Deaf1 expression can attenuate muscle atrophy and restore muscle regeneration in aged mice or mice with cachectic cancers. Together, our findings unveil an evolutionarily conserved role for DEAF1 in muscle regeneration, providing insights into the development of new therapeutic strategies against muscle atrophy. Abbreviations: DEAF1: Deformed epidermal autoregulatory factor-1; FOXO: Forkhead box O; MuSC: Muscle Stem Cell; PAX7: Paired box 7; PIK3C3: Phosphatidylinositol 3-kinase catalytic subunit type 3.
title: Ermüdungsverhalten von hochdruck-tordiertem Kupfer
Creators: name: Horky, Jelena Maria
Year: 2008

description: Im Rahmen dieser Diplomarbeit ist es gelungen, Lebensdauerkurven (S/N-Kurven) von hochdruck-tordiertem, ultafeinkörnigem Kupfer (HPT-Cu) aufzunehmen. Durch Einsatz eines Ultraschallresonanzsystems zur Wechselbelastung mit einer Frequenz von 20 kHz war es möglich, bis zu sehr hohen Zyklenzahlen (10 hoch 9) zu messen. Neben hochreinem und kommerziell reinem, HPT-Cu wurde bei gleicher Geometrie auch hochreines, geglühtes sowie kommerziell reines, ECAP-verformtes Kupfer untersucht. Zusätzlich zu den Lebensdauermessungen wurde die ermüdete Mikrostruktur sowie der Rissverlauf untersucht.
ANÁLISE SOBRE A CRISE DO SISTEMA PENITENCIÁRIO E  OS REFLEXOS DO FRACASSO DA PENA DE PRISÃO
Creators: name: Vitor Gonçalves Machado
Publisher: name: Zenodo
Year: 2013

description: RESUMO: A falência do modelo de pena privativa de liberdade é uma realidade atual e marcante em muitos sistemas penais. Há vários problemas e carências constatados na execução das penas de prisão, como a superlotação carcerária, o ócio ou inatividade forçada do preso, o ambiente propício à violência, o grande consumo de drogas e o elevado índice de reincidência. As soluções e alternativas para a problemática, bem como para a descrença quanto à busca da reintegração social do condenado como mais uma função da pena, parte primeiramente da sociedade, a qual ainda tolera as gravidades e mazelas das prisões e não muda o pensamento quanto ao preso e sua perspectiva da reinserção social, tratando-o como eterno excluído da sociedade. Um maior respeito à dignidade da pessoa humana e uma aproximação aos postulados oriundos do movimento do neoconstitucionalismo devem se fazer presentes, devendo o Estado, ainda, dar efetividade aos direitos fundamentais positivados em importantes tratados internacionais dos quais os diferentes países do globo são signatários. PALAVRAS-CHAVES: Prisão; crise; execução penal; reintegração social; dignidade da pessoa humana.
sj-docx-1-evi-10.1177_13563890221124637 – Supplemental material for Conducting focus groups in realist evaluation
Creators: name: Manzano, Ana
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, sj-docx-1-evi-10.1177_13563890221124637 for Conducting focus groups in realist evaluation by Ana Manzano in Evaluation
Preserving mitochondrial homeostasis protects against drug-induced liver injury via inducing OPTN (optineurin)-dependent Mitophagy
Creators: name: Wang, Jiajia
name: Qiu, Yueping
name: Yang, Lijun
name: Wang, Jincheng
name: He, Jie
name: Tang, Chengwu
name: Yang, Zhaoxu
name: Hong, Wenxiang
name: Yang, Bo
name: He, Qiaojun
name: Weng, Qinjie
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Disruption of mitochondrial function is observed in multiple drug-induced liver injuries (DILIs), a significant global health threat. However, how the mitochondrial dysfunction occurs and whether maintain mitochondrial homeostasis is beneficial for DILIs remains unclear. Here, we show that defective mitophagy by OPTN (optineurin) ablation causes disrupted mitochondrial homeostasis and aggravates hepatocytes necrosis in DILIs, while OPTN overexpression protects against DILI depending on its mitophagic function. Notably, mass spectrometry analysis identifies a new mitochondrial substrate, GCDH (glutaryl-CoA dehydrogenase), which can be selectively recruited by OPTN for mitophagic degradation, and a new cofactor, VCP (valosin containing protein) that interacts with OPTN to stabilize BECN1 during phagophore assembly, thus boosting OPTN-mediated mitophagy initiation to clear damaged mitochondria and preserve mitochondrial homeostasis in DILIs. Then, the accumulation of OPTN in different DILIs is further validated with a protective effect, and pyridoxine is screened and established to alleviate DILIs by inducing OPTN-mediated mitophagy. Collectively, our findings uncover a dual role of OPTN in mitophagy initiation and implicate the preservation of mitochondrial homeostasis via inducing OPTN-mediated mitophagy as a potential therapeutic approach for DILIs. Abbreviation: AILI: acetaminophen-induced liver injury; ALS: amyotrophic lateral sclerosis; APAP: acetaminophen; CALCOCO2/NDP52: calcium binding and coiled-coil domain 2; CHX: cycloheximide; Co-IP: co-immunoprecipitation; DILI: drug-induced liver injury; FL: full length; GCDH: glutaryl-CoA dehydrogenase; GOT1/AST: glutamic-oxaloacetic transaminase 1; GO: gene ontology; GSEA: gene set enrichment analysis; GPT/ALT: glutamic – pyruvic transaminase; INH: isoniazid; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MMP: mitochondrial membrane potential; MST: microscale thermophoresis; MT-CO2/COX-II: mitochondrially encoded cytochrome c oxidase II; OPTN: optineurin; PINK1: PTEN induced kinase 1; PRKN: parkin RBR E3 ubiquitin protein ligase; TIMM23: translocase of inner mitochondrial membrane 23; TOMM20: translocase of outer mitochondrial membrane 20; TSN: toosendanin; VCP: valosin containing protein, WIPI2: WD repeat domain, phosphoinositide interacting 2.
Additional file 3 of Implicit and explicit: a scoping review exploring the contribution of anthropological practice in implementation science
Creators: name: Faro, Elissa Z.
name: Taber, Peter
name: Seaman, Aaron T.
name: Rubinstein, Ellen B.
name: Fix, Gemmae M.
name: Healy, Heather
name: Reisinger, Heather Schacht
Publisher: name: figshare
Year: 2024
Subjects: subject: Anthropology
subject: FOS: Sociology

description: Additional file 3: Supplemental file 3. Included articles. Citations for all 227 articles included in the full-text analysis.
Structural interpretation of borehole images from onshore southern East Coast Basin wells
Creators: name: AG, Griffin
Publisher: name: GNS Science
Year: 2018

description: Three stratigraphic holes (Orui-1A, Ranui-2 and Te Mai-2), drilled in southeast Wairarapa to assist petroleum exploration in the onshore southern East Coast Basin, had acoustic and resistivity borehole image logs, conventional cores and wireline log data acquired through significant parts of the wells. The image logs have been interpreted, and where possible, calibrated to core observations. The interpretations provide an insight into the subsurface structure and stress, and to a lesser extent, the regional stress fields, and reservoir and seal integrity of this part of southern onshore East Coast Basin. The Orui-1A and Te Mai-2 wells were imaged using a borehole televiewer imaging tool (BHTV), which records the contrast in the acoustic amplitude and the travel time of the signal. The dominant fracture types identified in the processed images from these wells are those of low acoustic amplitude and those that have a visible travel time signal on the image logs. Poor image quality, particularly in Te Mai-2, meant that fewer features (both fractures and in situ stress) could be identified in the imaged interval, resulting in low confidence analysis. A resistivity microimaging tool was used to acquire image logs in Ranui-2. Low resistive (i.e. conductive) fractures are more numerous in the well. The resistivity-based images acquired in Ranui-2 are of better quality than the acoustic images of Orui-1A and Te Mai-2, making it easier to identify in situ stress features in the imaged interval. Fracture strike directions vary between formations and between wells. The Wanstead, Waipawa and Whangai formations were all encountered by more than one well, allowing comparisons to be made between the formations in the wells. Fracture strike orientations are similar in these formations (NNE–SSW to N–S, NE–SW, and NE–SW in the Wanstead, Waipawa, and Whangai formations respectively), particularly in the low resistivity and low acoustic amplitude fractures, despite the wells being separated by faults, or located in different structural blocks. Borehole breakouts were the dominant in-situ stress feature identified in the wells to establish the minimum horizontal stress direction (Shmin). The maximum horizontal stress direction (SHmax) is inferred to be at 90° to Shmin. There is a N–S SHmax direction in Orui-1A, while insufficient data in Te Mai-2 provides a low confidence NE–SW SHmax. Ranui-2 has a NW–SE-trending SHmax for the entire well, however when looking at the individual formations, the in-situ stress features change down the well, with SHmax changing from W–E to NW–SE. The identified fractures and in situ stress features in the imaged intervals from these wells provide an insight into the subsurface manifestations of deformation with depth in the southern Wairarapa area. The information gained from these features can be used in studies relating to fault seals and fracture permeability, and subsurface fluid flow between potential source to reservoir rocks. (auth)
title: Gedankenexperimente über Quantenmechanik und Gravitation
Creators: name: Krizek, Gerd Christian
Year: 2008

description: In dieser Arbeit sollen Gedankenexperimente über Quantenmechanik und Gravitation formuliert und analysiert werden. Wir wollen untersuchen welche Möglichkeiten im Rahmen eines Gedankenexperimentes bestehen mehr über die Beziehung von Quantenmechanik und Gravitation zu lernen. Diese Gedankenexperimente sollen auch auf Ihre Realisierbarkeit untersucht werden. In einem ersten Gedankenexperiment wird einer Überlegung Werner Heisenbergs zur Suche nach Unschärferelationen gefolgt und diese auf die Gravitation angewendet. Dabei wird ein Weg gezeigt Unschärferelationen für linearisierte Gravitationsfelder (gravitoelektromagnetische Felder) zu finden. In einem zweiten Gedankenexperiment wird die Dekohärenz bei Interferenzexperimenten durch gravitative Wechselwirkung untersucht und welche Auswirkungen dies für verschiedene Modelle des spontanen Wellenkollapses hat. Es werden zwei Gedankenexperimente mit Mach-Zehnder Interferometern formuliert, die eine Unterscheidung zwischen Alternativmodellen und der Quantenmechanik ermöglichen. Wie gezeigt wird, sind diese Experimente mit dem momentanen Stand der Experimental-Technik nicht zu realisieren und dienen der Anschauung.
Additional file 1 of Phenotypic divergence between broiler and layer chicken lines is regulated at the molecular level during development
Creators: name: Contriciani, Renata Erbert
name: Grade, Carla Vermeulen Carvalho
name: Buzzatto-Leite, Igor
name: da Veiga, Fernanda Cristina
name: Ledur, Mônica Corrêa
name: Reverter, Antonio
name: Alexandre, Pamela Almeida
name: Cesar, Aline Silva Mello
name: Coutinho, Luiz Lehmann
name: Alvares, Lúcia Elvira
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 1
Effects of Visibility and Alarm Modality on Workload, Trust in Automation, Situation Awareness, and Driver Performance
Creators: name: Shah, Smruti J.
Publisher: name: Old Dominion University Libraries
Year: 2016

description: Driving demands sustained driver attention. This attentional demand increases with decreasing field visibility. In the past researchers have explored and investigated how collision avoidance warning systems (CAWS) help improve driving performance. The goal of the present study is to determine whether auditory or tactile CAWS have a greater effect on driver performance, perceived workload, system trust, and situation awareness (SA). Sixty-three undergraduate students from Old Dominion University participated in this study. Participants were asked to complete two simulated driving sessions along with Motion Sickness Susceptibility Questionnaire, Background Information Questionnaire, Trust Questionnaire, NASA Task Load Index Questionnaire, Situation Awareness Rating Technique Questionnaire, and Simulator Sickness Questionnaire. Analyses indicated that drivers in the tactile modality condition had low perceived workload. Drivers in the heavy fog visibility condition had the highest number of collisions and red-light tickets. Drivers in the heavy fog condition also reported having the highest overall situation awareness. Drivers in the clear visibility condition trusted tactile alarms more than the auditory alarms, whereas drivers in the heavy fog condition trusted auditory alarms more than tactile alarms. The findings of this investigation could be applied to improve the design of CAWS that would help improve driver performance and increase safety on the roadways.