cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
New draft item
Creators: name: FRANCISCO IVO DANTAS CAVALCANTI
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: The present article deigned to analyze the theory of legislative reception within the constitutional systems, from a historiographic and socio-juridical approach. It was pointed out that the need for a permanence of the constitutional text (as for the rest of the whole system) is opposed by a relative immutability, since the constitutional texts can not be incorporated. From this, it was concluded that - The study of the Legislative Reception, for which other denominations are used, is the central theme in the study of Comparative Law; Its implementation takes place through several processes, and in the analysis of the concrete case, none of them, alone, will be sufficient to explain the reality of a certain legal system, reason why some authors use the concept of legal field; When talking about reception, it can not be forgotten that this can occur not only through legislation, but also through legal production, that is to say, teaching and doctrinal production; Among the various examples of Reception, the most expressive is the Roman Law in Europe, from the Middle Ages to the Codification period and when they are received, institutions or models will have to undergo acclimatization or acculturation in order to be effective in Their new habitat.
title: Strategic spatiotemporal vaccine distribution increases the survival rate in an infectious disease like Covid-19
Creators: name: Grauer, Jens
name: Löwen, Hartmut
name: Liebchen, Benno
Publisher: name: Springer Nature
Year: 2022

description: Present hopes to conquer the Covid-19 epidemic are largely based on the expectation of a rapid availability of vaccines. However, once vaccine production starts, it will probably take time before there is enough vaccine for everyone, evoking the question how to distribute it best. While present vaccination guidelines largely focus on individual-based factors, i.e. on the question to whom vaccines should be provided first, e.g. to risk groups or to individuals with a strong social-mixing tendency, here we ask if a strategic spatiotemporal distribution of vaccines, e.g. to prioritize certain cities, can help to increase the overall survival rate of a population subject to an epidemic disease. To this end, we propose a strategy for the distribution of vaccines in time and space, which sequentially prioritizes regions with the most new cases of infection during a certain time frame and compare it with the standard practice of distributing vaccines demographically. Using a simple statistical model we find that, for a locally well-mixed population, the proposed strategy strongly reduces the number of deaths (by about a factor of two for basic reproduction numbers of R₀∼1.5−4 and by about 35% for R₀∼1). The proposed vaccine distribution strategy establishes the idea that prioritizing individuals not only regarding individual factors, such as their risk of spreading the disease, but also according to the region in which they live can help saving lives. The suggested vaccine distribution strategy can be tested in more detailed models in the future and might inspire discussions regarding the importance of spatiotemporal distribution rules for vaccination guidelines.
title: sainte Élisabeth de Hongrie
Creators: name: Centre De Recherches Historiques / Anthropologie Historique Du Long Moyen Âge
Publisher: name: EHESS (School for Advanced Studies in Social Sciences)
Year: 2019

description: Princesse, franciscaine ; fille du roi de Hongrie André II, femme du landgrave de Thuringe louis IV dit le saint ; représentée avec une couronne sur la tête, un livre dans les mains sur lequel sont posées deux autres couronnes, présentant la maquette de l'église de Marburg et montrant des roses dans un pan de sa robe ; attributs : un pain ou un poisson, une cruche, un mendiant à ses pieds.
CIVIL LIABILITY COMPANY'S OBJECTIVE FOR ACTS OF CORRUPTION IN LIGHT OF LAW 12,846 / 2013
Creators: name: Reis, Clayton
name: Kichileski, Gustavo Carvalho
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: This article intends to analyze the objective civil liability of the company for acts of corruption in light of Law nº 12.846 / 2013. It is known that such a popular initiative was fundamental for the promulgation of this law, where the National Congress felt pressured by the demonstrations, and tried to give a positive response to Brazilian society with the drafting of law 12,846 / 2013, facing impunity and the corruption pandemic Faced in the country. The Anti-Corruption Law was widely known for its severe sanctions against companies, in order to reprimand and prevent corporate corruption. It is possible to conclude that, since Brazil does not yet have the criminalization of corruption in the private sector, LAC is currently a vital tool for repression and prevention of corruption in the business sector.
CULTURE AND MULTICULTURALISM: LGBT IDENTITY, TRANSEXUALS AND GENDER ISSUES
Creators: name: LIVIA GAIGHER BÓSIO CAMPELLO
name: WELINGTON OLIVEIRA DE SOUZA COSTA
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: This article discusses the concept of culture and multiculturalism, and the identity aspects of the LGBT population - Lesbians, Gays, Bisexuals, Transvestites, Transsexuals and Transgender, who are gradually gaining ground in research and especially in society. Considering their history, into the big concept of culture, they have created their own identities, which were not widespread and not integrated into heteronormativity society. Nowadays, as their voice gains strength, especially because of the democratic state of law, LGBT identity demands its space and call up the debate for equality without, however, de-characterize their identities. In addition, the research specifically treats the case of the transsexual population and their gender issues in sexual diversity. The objective of this work, observing the problem of prejudice still existing against this population, is to demonstrate the possibility of insertion and dialogue of the LGBT identity, dealing specifically with the case of transsexuals. For that, concepts such as culture, diversity and multiculturalism are presented, associating them with the LGBT cause in the transexuality aspect. The research, developed from the deductive method, bibliographical and documental, aims, finally, to demonstrate the relevance of the theme for the effective social insertion of this minority, according to the construction of their identities and gender.
FOREIGN CORRUPT PRACTICES ACT: A BRIEF ANALYSIS OF THE LAW THAT GAVE RISE TO THE INTERNATIONAL FIGHT AGAINST CORRUPTION.
Creators: name: NUNO M. M. S. COELHO
name: HELIMARA MOREIRA LAMOUNIER HERINGER
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: This paper aims to analyze an FCPA, the US anti-bribery law, a legal instrument for combating corruption, especially that arising from bribes to government officials, both in the United States and abroad. It assesses the damage caused by corruption and their impact on issues such as waste of public resources; environment; And social inequality. It outlines a profile of the FCPA, presenting its history, its characteristics and its scope. It also analyzes the main criticism of current anti-corruption efforts, the accusation of imperialism, of a supposed intrusion by the United States into the affairs of other countries affecting its sovereignty.
IL-7-dependent maintenance of ILC3s is required for normal entry of lymphocytes into lymph nodes
Creators: name: Yang, Jie
name: Cornelissen, Ferry
name: Papazian, Natalie
name: Reijmers, Rogier M
name: Llorian, Miriam
name: Cupedo, Tom
name: Coles, Mark
name: Seddon, Benedict
Publisher: name: The Francis Crick Institute
Year: 2021
Subjects: classificationCode: Computational & Systems Biology
subject: Computational & Systems Biology

description: IL-7 is essential for the development and homeostasis of T and B lymphocytes and is critical for neonatal lymph node organogenesis because Il7-/- mice lack normal lymph nodes. Whether IL-7 is a continued requirement for normal lymph node structure and function is unknown. To address this, we ablated IL-7 function in normal adult hosts. Either inducible Il7 gene deletion or IL-7R blockade in adults resulted in a rapid loss of lymph node cellularity and a corresponding defect in lymphocyte entry into lymph nodes. Although stromal and dendritic cell components of lymph nodes were present in normal numbers and representation, innate lymphoid cell (ILC) subpopulations were substantially decreased after IL-7 ablation. Testing lymphocyte homing in bone marrow chimeras reconstituted with Rorc-/- bone marrow confirmed that ILC3s in lymph nodes are required for normal lymphocyte homing. Collectively, our data suggest that maintenance of intact lymph nodes relies on IL-7-dependent maintenance of ILC3 cells.
POSSIBLE RESERVE AND SOCIAL RIGHTS: FORECASTING THE ACHIEVEMENT STANDARDS
Creators: name: DIRCEU PEREIRA SIQUEIRA
name: MARIA EDUARDA PIRES PETRIS
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: The theory of the Reserve Cause of the Possible was originated in Germany facing the conflict of the large number of Young people wishing to ingress the medical school and the limitation of vacancies offered by the State. This issue led to the creation of this theory because the German State had no financial means to afford the education to all who wanted to study Medicine. Thus, the reserve clauseof the possible Works, nowadays, as a valve to excuse the Governm ent from the obligations as a guarantor of the States, like it occurs in our Braziian legal system in which the Constitution guarantees the social rights. However, the lack of cohesion and harmony generates a negative impact to those who need the State as guarantor of their rights.
Effect of spray properties on aerosol scavenging efficiency with water mist
Creators: name: Liang, Hui
name: Zhou, Qian
name: Erkan, Nejdet
name: Suzuki, Shunichi
Publisher: name: Taylor & Francis
Year: 2021
Subjects: Biophysics
Biochemistry
Space Science
Physical Sciences not elsewhere classified
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Astronomical and Space Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: In the foreseen decommissioning plans of damaged Fukushima Daiichi reactors, submicron aerosol particles will be generated when retrieving fuel debris from reactor buildings by cutting it into small pieces. A multi-nozzle spray system will be used to scavenge these aerosol particles inside the primary containment vessel. To improve the aerosol removal efficiency of the multi-nozzle spray system, it is now necessary to study the aerosol removal performance by different single spray nozzles with different spray properties (spray angle, droplet velocity, etc.). To improve the aerosol scavenging efficiency, a new method with water mist was proposed to aggregate with aerosol particles and form large-sized coagulated aerosol-mist particle clusters, which can subsequently be removed by spray with higher efficiency. In this study, the effect of spray properties on aerosol removal efficiency with preexisting water mist was investigated using three different spray nozzles. The experimental results showed that a larger droplet velocity led to stronger vortex circulation and faster gaseous entrainment from outer spray area into spray region, resulting in a smaller circulation period of gas entrainment by spray and higher aerosol removal efficiency. The numerical simulations of aerosol removal by different spray nozzles without mist were also conducted to provide more insights into the aerosol removal process. By comparing the experiment and simulation results, it is found that the accumulated spray water in the lower plenum of the vessel and the water film formed on the vessel sidewalls also contributed to aerosol removal, especially for the particles with large Stokes numbers. Copyright © 2021 American Association for Aerosol Research
title: saint Michel
Creators: name: Centre De Recherches Historiques / Anthropologie Historique Du Long Moyen Âge
Publisher: name: EHESS (School for Advanced Studies in Social Sciences)
Year: 2019

description: Archange, chef de la milice céleste ; il intervient dans l'Apocalypse en terrassant le dragon de l'Apocalypse, ou dans la pesée des âmes du Jugement dernier, il expulse Satan du Paradis ; il apparut à saint Grégoire le Grand ; représenté en guerrier avec l'armure et le bouclier ; attributs : la balance et l'épée.
title: 01_2725
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Effect of Spray Properties on Aerosol Scavenging Efficiency with Water Mist
Creators: name: Liang, Hui
name: Zhou, Qian
name: Erkan, Nejdet
name: Suzuki, Shunichi
Publisher: name: Taylor & Francis
Year: 2021
Subjects: Biophysics
Biochemistry
Space Science
Physical Sciences not elsewhere classified
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Astronomical and Space Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: In the foreseen decommissioning plans of damaged Fukushima Daiichi reactors, submicron aerosol particles will be generated when retrieving fuel debris from reactor buildings by cutting it into small pieces. A multi-nozzle spray system will be used to scavenge these aerosol particles inside the primary containment vessel. To improve the aerosol removal efficiency of the multi-nozzle spray system, it is now necessary to study the aerosol removal performance by different single spray nozzles with different spray properties (spray angle, droplet velocity, etc.). To improve the aerosol scavenging efficiency, a new method with water mist was proposed to aggregate with aerosol particles and form large-sized coagulated aerosol-mist particle clusters, which can subsequently be removed by spray with higher efficiency. In this study, the effect of spray properties on aerosol removal efficiency with preexisting water mist was investigated using three different spray nozzles. The experimental results showed that a larger droplet velocity led to stronger vortex circulation and faster gaseous entrainment from outer spray area into spray region, resulting in a smaller circulation period of gas entrainment by spray and higher aerosol removal efficiency. The numerical simulations of aerosol removal by different spray nozzles without mist were also conducted to provide more insights into the aerosol removal process. By comparing the experiment and simulation results, it is found that the accumulated spray water in the lower plenum of the vessel and the water film formed on the vessel sidewalls also contributed to aerosol removal, especially for the particles with large Stokes numbers.
Additional file 1: of Admission serum sodium and potassium levels predict survival among critically ill patients with acute kidney injury: a cohort study
Creators: name: Gao, Xu-ping
name: Zheng, Chen-fei
name: Liao, Min-qi
name: He, Hong
name: Liu, Yan-hua
name: Jing, Chun-xia
name: Zeng, Fang-fang
name: Chen, Qing-shan
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy
subject: Hematology

description: Table S1. STROBE Statementâ checklist of items that should be included in reports of observational studies. Table S2. Baseline characteristics of the study population according to admission serum sodium level a. Table S3. Baseline characteristics of the study population according to admission serum potassium level a. Table S4. All-cause mortality according to admission serum sodium levels across admission serum potassium levels among critically ill patients with acute kidney injury. Table S5. Subgroup analysis of the associations between admission serum sodium level and 30-day all-cause mortality. Table S6. Subgroup analysis of the associations between admission serum potassium level and 30-day all-cause mortality. (DOCX 46 kb)
title: sainte Thècle
Creators: name: Centre De Recherches Historiques / Anthropologie Historique Du Long Moyen Âge
Publisher: name: EHESS (School for Advanced Studies in Social Sciences)
Year: 2019

description: Protomartyre de l'église d'Orient dont la légende est liée à l'apostolat de saint Paul ; attributs : tient son bras-reliquaire, à ses pieds se trouvent une colonne enflammée et des lions couchés; parfois des serpents s'enroulent autour de son bras.
INDICACIONES GEOGRÁFICAS: UN MECANISMO JURÍDICO APTO A IMPULSIONAR EL DESARROLLO COMO REVELADOR DE LAS DIVERSAS FACETAS DE LA SUSTENTABILIDAD
Creators: name: ISABEL CHRISTINE SILVA DE GREGORI
name: NATHALIE KUCZURA NEDEL
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: Geographical indications are defined as being distinctive signs of origin or quality related to the geographical environment in which the product or service is produced. It is an intellectual property mechanism that has two species - indication of origin and denomination of origin - and that values ​​the local product or service, certifying the quality and provenance. That makes products and services have a competitive advantage, and are also more sought after by consumers, and can still add value to them. Thus, explicitly, the mechanism in vogue confers economic benefits. In this context, the present study aims to verify if the geographical indications serve to protect the effectively sustainable development. For that, the deductive method was used as a method of approach, since it is based on a downlink and method of procedure comparative, since the Institute of Geographical Indications is compared with the concept of sustainable development. With the use of these methods, it was possible to gauge that geographical indications do not give opportunity to merely economic development, but also attack other facets of sustainability, such as social and cultural.
THE RESIGNIFICATION OF MINE ACTION AS A WAY TO ACHIEVE SUSTAINABLE DEVELOPMENT
Creators: name: Deilton Ribeiro Brasil
name: Natielli Efigênia Mucelli Rezende Veloso
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: The objective of this paper is to analyze in which ways the actions made towards the prevention and resolution of problems caused by landmines, cluster munitions and other explosive remnants of war are important to achieve a sustainable development. The methodology used in this article will be the critical-deductive approach, relying itself upon reading and analyzing literature and international legal framework on the matter, in order to demonstrate the crucial nature of post bellum mine action for effective economic, social and environmental development, as well as an effective assurance of the human rights of communities in reconstruction in an after-conflict context.
THE ILLEGITIMIC EXERCISE OF THE HOMOPHOBIC SPEECH HATE UNDER THE OPTICS OF SEXUALITY AND HUMAN DIGNITY
Creators: name: VALÉRIA SILVA GALDINO CARDIN
name: ANTONIO CARLOS SEGATTO
name: CAIO EDUARDO COSTA CAZELATTO
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: This research aims to analyze, through the theoretical method, the sexuality and the dignity of the human person as legal limits to freedom of expression before the discourse of hatred with the homophobic bias. In order to do so, it dealt with the norms of constitutional principles and the construction of human dignity as a fundamental precept of the Democratic State of Law, as well as their relationship and their importance within the Federal Constitution of 1988. In the same way, human sexuality and its legal protection, and it is verified that this is a fundamental right and personality that is essential to the full and dignified development of its holder, but also analyzed the social vulnerability that the violation of this right causes sexual minorities. In addition, homophobia was addressed as a preponderant factor in the social exclusion of the LGBT community, as well as the impacts that homophobic hate speech has on its victims. To this end, the limits of freedom of expression were verified, which should be based on the principle of the dignity of the human person, as well as on the free expression of sexuality. In the event of collisions between the fundamental rights of sexuality and freedom of expression, it should prevail over it, in view of the principles of weighting and proportionality, aiming at the purposes of constitutional precepts.
RIGHT TO FULL DEVELOPMENT IN FACE OF THE BRAZILIAN NATIONAL POLICY OF SOLID WASTE
Creators: name: Vladmir Oliveira Da Silveira
name: Fernandes, Ana Carolina Souza
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: Contemporary society is constantly changing. Individual rights were once considered absolute and untouchable. Over time, other rights were counterbalanced with those individual rights, such as social rights, right to development and even environmental rights. That said, this article focuses, through a deductive methodology and on the basis of legislative and doctrinal analysis, to address the defense of these diffuse rights within the human rights context, the theory of full development and the so-called shared responsibility, so that it can be verified if the Brazilian National Policy of Solid Waste has contributed – or if it still contributes – to instilling in the population the idea of ​​corporate citizenship, considering the importance, in casu, of the environment for this and future generations. 
Open Access Publizieren - so geht's
Creators: name: Rücknagel, Jessika
name: Schmeja, Stefan
Publisher: name: Zenodo
Year: 2022
Subjects: Open Access
Open-Access-Transformation

description: Immer mehr Wissenschaftler*innen entscheiden sich für eine Open Access-Publikation und gestalten so aktiv die Transformation hin zu einer offenen Wissensgesellschaft. Um angesichts der zahlreichen Angebote und Möglichkeiten den Überblick zu behalten, bot der Open Access Talk "Open Access Publizieren - so geht's" am 24. Februar 2022, einen praktischen Einstieg ins Thema Open-Access-Publikationsmöglichkeiten. Dabei wurde u. a. auf folgende Fragen eingegangen: Wo kann ich Open Access publizieren? Welche Modelle gibt es, um eine Publikation offen bereit zu stellen? Was muss ich bei den entsprechenden Publikationsmodellen beachten? Wer kann mich beim Publikationsprozess unterstützen?
Von closed zu open - wie Sie Ihr Journal zu Open Access flippen
Creators: name: van Edig, Xenia
name: Rücknagel, Jessika
Publisher: name: Zenodo
Year: 2022
Subjects: Open Access

description: Im Vortrag "Von closed zu open - wie Sie Ihr Journal zu Open Access flippen" geben die Referent*innen wertvolle Hinweise, die Herausgeber*innen von wissenschaftlichen Journalen dabei unterstützen ihre Zeitschrift zu einer Open-Access-Zeitschrift zu transformieren. Hierzu gehören Aspekte wie rechtliche Hintergründe, Veränderungen bei administrativen Abläufen und die Kommunikation des veränderten Betriebsmodells sowie die Bewerbung des Angebots. Dabei behandeln wir unter anderem folgende Fragen: Welche Möglichkeiten stehen mir offen, um das Jorunal als Open-Access-Zeitschrift zu betreiben? Was muss ich zum nachhaltigen Betrieb beachten? Was muss die Zeitschrift leisten, um als professionelle Open-Access-Zeitschrift angesehen zu werden? Der Vortrag wurde im Rahmen der Reihe Open Access Talk des BMBF-geförderten Projektes open-access.network gehalten.
20 YEARS AFTER THE DOLLY SHEEP: LEGAL PROTECTION OF THE CLONING OF ANIMALS IN VIEW OF THE LEGAL NATURE OF THE GENETIC HERITAGE AS AN ENVIRONMENTAL GOOD
Creators: name: Fiorillo, Celso Antônio Pacheco
name: Ferreira, Renata Marques
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: The cloning of animals, defined in Brazilian legislation as a process of asexual reproduction, artificially produced, based on a single genetic patrimony, with or without The use of genetic engineering techniques, became constitutional protection in theface of its environmental beacon as established in Art.225, paragraph 1, item II becoming legally interpreted under Brazilian law in view of the legal nature of the genetic heritage as well Environmental protection.
Identification of potential biomarkers for systemic lupus erythematosus diagnosis using two-dimensional differential gel electrophoresis (2D-DIGE) and mass spectrometry
Creators: name: Ferreira, Tamara Aparecida Reis
name: Hélida Monteiro De Andrade
name: Pádua, Paulo Madureira De
name: Carvalho, Maria Das Graças
name: Pires, Simone Da Fonseca
name: Oliveira, Ivana Helena Rocha
name: Lima, Bruna Soares Souza
name: Júnior, Luis Carlos Fialho
name: Cicarini, Walter Batista
name: Chapeourouge, Donat Alexander
name: Perales, Jonas Henrique
name: Guimarães, Tânia Mara Pinto Dabés
name: Toledo, Vicente De Paulo Coelho Peixoto De
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Systemic lupus erythematosus (SLE) is an autoimmune disease of the connective tissue with a large spectrum of clinical manifestations. Immune deregulation leads to autoantibody and immune complexes overproduction, complement activation, and persistent tissue inflammation. Considering that the current diagnosis depends on the interpretation of the complex criteria established by the American College of Rheumatology and that the disease course is characterized by unpredictable activations and remissions, each patient develops different manifestations, and therefore, the discovery of specific biomarkers is urgently required. Therefore, this study aimed to identify putative biomarkers for active and inactive SLE potentially capable in distinguishing laboratorial SLE from other autoimmune diseases. The 2D-DIGE proteomics technique was used to evaluate the differential abundance of proteins between patients with active SLE, inactive SLE, patients with other autoimmune disease, and healthy individuals. Six proteins showed increased abundance in active SLE (A) and inactive SLE (I) compared to the C and O groups, but not between groups A and I. There were two transthyretin (TTR) fragments or proteins with a structure similar to TTR (accession numbers: PDB: 1GKO_A and 2PAB_A), retinol-binding protein 4 (RBP4) isoform X1 (no information in databases such as UNIPROT), and antibody fragments. Two proteins, APO-AIV and SP-40,40, were upregulated in group A than in O and C and in group I versus C, but not in group I versus O. Therefore, we suggest these proteins to be considered as candidates for the diagnosis of SLE.
Short term outcomes of rotational atherectomy versus orbital atherectomy in patients undergoing complex percutaneous coronary intervention: a systematic review and meta-analysis
Creators: name: Doshi, Rajkumar
name: Thakkar, Samarthkumar
name: Patel, Krunalkumar
name: Majmundar, Monil
name: Shlofmitz, Evan
name: Kumar, Ashish
name: Gupta, Neelesh
name: Adalja, Devina
name: Patel, Harsh P.
name: Jauhar, Rajiv
name: Meraj, Perwaiz
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Hematology

description: Coronary artery calcification (CAC) is one of the paramount hurdles for percutaneous coronary intervention (PCI) since it impedes stent delivery and complete expansion. This study intended to evaluate the short-term clinical and procedural outcomes comparing rotational atherectomy (RA) and orbital atherectomy (OA) in patients with heavily calcified coronary lesions undergoing PCI. Design: This systematic review and meta-analysis included all head-to-head published comparisons of coronary RA versus OA. Procedural endpoints and post-procedural clinical outcomes (30 days/in-hospital), were compared. RevMan 5.3 software was used for data analysis. Results: Seven retrospective observational investigations with a total of 4623 patients, including 3203 patients in the RA group and 1420 patients in the OA group, were incorporated. Compared with OA, the RA group was associated with a higher incidence of myocardial infarction at short-term follow-up (OR: 1.56, 95% CI: 1.07–2.29, p = .02, I2 = 0%). No difference was noted among other short-term post-procedural clinical outcomes including all-cause mortality, target vessel revascularization, or major adverse cardiac events. Among procedural complications, RA was associated with reduced coronary artery dissection and arterial perforation. Increased fluoroscopy time was observed in the RA cohort as compared with OA (MD: 4.78, 95% CI: 2.25–7.30, p = .0002, I2 = 80%). Conclusion: RA was associated with fewer vascular complications, but at a cost of higher incidence of myocardial infarction and higher fluoroscopy time compared with OA, at short term follow-up. OA is a safe and effective alternative for the management of CAC.
Train - the - Trainer - Workshop: Open Access für Fachreferent*innen der Geistes-, Sozial- und Rechtswissenschaften
Creators: name: Stockhusen, Sabrina Dr.
Publisher: name: Zenodo
Year: 2022
Subjects: open-access network
Train-the-Trainer-Workshop
Open Access

description: Die Präsentation diente dem zweitägigen Train-the-Trainer-Workshop am 30. und 31.03.2022 als Basis. Der Online-Workshop richtete sich an Fachreferent*innen der Geistes-, Sozial- und Rechtswissenschaften – Open Access - Multiplikator*innen für eine offene Wissenschaft. Im Vordergrund standen der Erwerb von Kenntnissen und die Anwendung didaktischer Methoden, die bei der Ausrichtung eigener Veranstaltungen unterstützen können, der Erfahrungsaustausch zum Thema Open Access und die Möglichkeit zur Vernetzung untereinander.
 Die Präsentation liegt als PPTX-Datei vor und kann gemäß der CC-BY-Lizenz nachgenutzt werden. Von dieser Lizenz ausgenommen sind verwendete Icons, Logos, Screenshots und Abbildungen. Wir begrüßen ausdrücklich die Weiterentwicklung und Anpassungen an die eigenen projektbezogenen, institutionellen Umsetzungen und Vorgaben und freuen uns über Hinweise und Rückmeldungen vorgenommener Änderungen.
title: Track choice and socio-economic origin: measuring and explaining academic inhibition ( LIEPP Policy Brief, n°23)
Creators: name: Guyon, Nina
name: Huillery, Elise
Publisher: name: Sciences Po - LIEPP
Year: 2016
Subjects: subject: FOS: Social sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Les élèves d’origine sociale modeste aspirent à des filières académiques moins sélectives que leurs pairs de même niveau scolaire mais d’origine sociale favorisée. Plusieurs raisons sont mises à jour : premièrement, les élèves d’origine modeste sous-estiment leurs capacités scolaires actuelles par rapport aux élèves d’origine favorisée ; ensuite, ils anticipent une forte différence dans leurs chances de succès dans le futur ; en outre, ils ont tendance à se conformer à leurs pairs. Par ailleurs, l’action des parents et des enseignants dans le processus d’orientation tend à accroître ces inégalités d’aspirations pour les élèves faibles, tandis qu’elle réduit ces inégalités pour les élèves au-dessus de la médiane. Ces résultats permettent de proposer des pistes d’interventions permettant de réduire les inégalités sociales d’aspirations scolaires.
description: Pupils from modest socio-economic backgrounds choose less selective academic tracks than others at the same level of ability. Pupils from more modest backgrounds underestimate their own ability; they believe that they are less likely to succeed in a selective academic track, and they have a tendency to conform to the choices of their peers. In addition, outside influence (from the parents or school) over the course of the last year of junior high tends to exacerbate the gap for weaker students, but narrow the gap for stronger students. We propose specific policy interventions based on these findings.
New draft item
Creators: name: Deilton Ribeiro Brasil
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: The objective of this paper is to analyze in which ways the actions made towards the prevention and resolution of problems caused by landmines, cluster munitions and other explosive remnants of war are important to achieve a sustainable development. The methodology used in this article will be the critical-deductive approach, relying itself upon reading and analyzing literature and international legal framework on the matter, in order to demonstrate the crucial nature of post bellum mine action for effective economic, social and environmental development, as well as an effective assurance of the human rights of communities in reconstruction in an after-conflict context.
Stimuli
Creators: name: Vokey, John R
name: Tangen, Jason M
name: Searston, Rachel A.
name: Thompson, Matthew B
Publisher: name: OSF Registries
Year: 2018

description: This component includes all stimuli for this experiment, and links to the original images used to generate the scrambled images. AllStimuli - ScrambleMaterials.zip (2.99GB) contains the full set of 117,320 16×16 scrambled images of faces, birds, and paintings required for rerunning this experiment with the correct file structure.
Additional file 6 of Coal dust exposure triggers heterogeneity of transcriptional profiles in mouse pneumoconiosis and Vitamin D remedies
Creators: name: Mu, Min
name: Li, Bing
name: Zou, Yuanjie
name: Wang, Wenyang
name: Cao, Hangbing
name: Zhang, Yajun
name: Sun, Qixian
name: Chen, Haoming
name: Ge, Deyong
name: Tao, Huihui
name: Hu, Dong
name: Yuan, Liang
name: Tao, Xinrong
name: Wang, Jianhua
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 6. Figure S6. Toxic effects of coal dust on MLE-12 cells. Causing 50% inhibition of cell survival (CC50) of coal dust was measured in MLE-12 cells treated with different dose (A) and different time point at 200 μg/ml (B) (*P < 0.05, **P < 0.01, ***P < 0.001, Treatment vs Control).
title: Politiques publiques et décision électorale. Retour sur la présidentielle de 2012 ( LIEPP Policy Brief, n°07)
Creators: name: Grossman, Emiliano
name: Sauger, Nicolas
Publisher: name: Sciences Po - LIEPP
Year: 2013
Subjects: subject: FOS: Social sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Dans quelle mesure les électeurs prennent-ils en compte les positions des candidats sur des enjeux précis dans leur décision de vote ? Pour répondre à cette question, nous analysons une enquête postélectorale, réalisée après le second tour de l’élection présidentielle en France de 2012. Nous regardons le positionnement des électeurs et le placement perçu des candidats sur quatre enjeux : le nucléaire, l’immigration, les fonctionnaires et l’intégration européenne. L’étude montre que certains enjeux jouent un rôle plutôt marginal dans le choix du candidat, comme la position sur le nucléaire, alors que d’autres jouent plus d’un côté de l’échiquier politique que d’autres ou ne jouent que pour certains candidats, comme les fonctionnaires. Enfin, nous démontrons l’importance de l’immigration dans le choix du candidat, enjeu qui semblait pourtant avoir été marginalisé par le contexte économique au cours de la campagne.
description: To what extent do voters take into account the candidates' positions on specific issues in their voting decision? To answer this question, we analyze a post­election survey conducted after the second round of the presidential election in France in 2012. We look at voters’ positions and the perceived positions of candidates on four issues: nuclear power, immigration, civil servants and European integration. The study shows that some issues play a rather marginal role in the choice of the candidate, as the position on nuclear power. Others are more important on one side of the political spectrum and some play a role only for some candidates, such as civil servants. Finally, we demonstrate the importance of immigration in the choice of candidate, an issue which seemed to have been marginalized by the economic situation in the country.
title: saintes onze mille vierges
Creators: name: Centre De Recherches Historiques / Anthropologie Historique Du Long Moyen Âge
Publisher: name: EHESS (School for Advanced Studies in Social Sciences)
Year: 2019

description: Elles accompagnent sainte Ursule dans son voyage vers Cologne, converties à la foi elles abordèrent à un port de la Gaule nommé Tyelle, où un ange apparut et prédit qu'elles recevraient la couronne du martyre. en 238, Jules prince de la nation des Huns, et son armée, les massacra à leur arrivée à Cologne.
CONTROL OF CONVENTIONALITY
Creators: name: Revista Jurídica 2017.1
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: A pesar de la diversidad de intereses de los Estados, la idea de la constitución de las reglas de conducta de la sociedad internacional, cuanto a la protección de los derechos humanos es cada vez más premente. Así, los conceptos y recomendaciones tradicionalmente consagrados por el derecho internacional, por ejemplo la soberania de los Estados, los tribunales internacionales para los casos de los derechos humanos, etc. han sido cambiados con lo tiempo. Con las políticas adoptadas en la arena internacional en favor de los derechos de la persona humana, existe una necesidad de tratar el tema del Control de Convencionalid, que va garantizar eficacia de las legislaciones internacionales y permitir dirimir conflictos entre normas internas y normas de derecho internacional
title: consécration
Creators: name: Centre De Recherches Historiques / Anthropologie Historique Du Long Moyen Âge
Publisher: name: EHESS (School for Advanced Studies in Social Sciences)
Year: 2019

description: A) Cérémonie vouant au culte une église ou un autel; ne pas utiliser dédicace qui désigne le don d'un livre. b) Investiture d'un évêque ou d'un pape; entrée en religion d'une moniale.
Additional file 7 of Coal dust exposure triggers heterogeneity of transcriptional profiles in mouse pneumoconiosis and Vitamin D remedies
Creators: name: Mu, Min
name: Li, Bing
name: Zou, Yuanjie
name: Wang, Wenyang
name: Cao, Hangbing
name: Zhang, Yajun
name: Sun, Qixian
name: Chen, Haoming
name: Ge, Deyong
name: Tao, Huihui
name: Hu, Dong
name: Yuan, Liang
name: Tao, Xinrong
name: Wang, Jianhua
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 7. Advanced analytical methods.
THE RESIGNIFICATION OF MINE ACTION AS A WAY TO ACHIEVE SUSTAINABLE DEVELOPMENT
Creators: name: Deilton Ribeiro Brasil
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: The objective of this paper is to analyze in which ways the actions made towards the prevention and resolution of problems caused by landmines, cluster munitions and other explosive remnants of war are important to achieve a sustainable development. The methodology used in this article will be the critical-deductive approach, relying itself upon reading and analyzing literature and international legal framework on the matter, in order to demonstrate the crucial nature of post bellum mine action for effective economic, social and environmental development, as well as an effective assurance of the human rights of communities in reconstruction in an after-conflict context.
Identification of potential inhibitors of Fasciola gigantica thioredoxin1: computational screening, molecular dynamics simulation, and binding free energy studies
Creators: name: Rohit Shukla
name: Shukla, Harish
name: Parismita Kalita
name: Sonkar, Amit
name: Pandey, Tripti
name: Dev Bukhsh Singh
name: Awanish Kumar
name: Timir Tripathi
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Fasciola gigantica is the causative organism of fascioliasis and is responsible for major economic losses in livestock production globally. F. gigantica thioredoxin1 (FgTrx1) is an important redox-active enzyme involved in maintaining the redox homeostasis in the cell. To identify a potential anti-fasciolid compound, we conducted a structure-based virtual screening of natural compounds from the ZINC database (n = 1,67,740) against the FgTrx1 structure. The ligands were docked against FgTrx1 and 309 ligands were found to have better docking score. These compounds were evaluated for Lipinski and ADMET prediction, and 30 compounds were found to fit well for re-docking studies. After refinement by molecular docking and drug-likeness analysis, three potential inhibitors (ZINC15970091, ZINC9312362, and ZINC9312661) were identified. These three ligands were further subjected to molecular dynamics simulation (MDS) to compare the dynamics and stability of the protein structure after binding of the ligands. The binding free energy analyses were calculated to determine the intermolecular interactions. The results suggested that the two compounds had a binding free energy of –82.237, and –109.52 kJ.mol−1 for compounds with IDs ZINC9312362 and ZINC9312661, respectively. These predicted compounds displayed considerable pharmacological and structural properties to be drug candidates. We concluded that these two compounds could be potential drug candidates to fight against F. gigantica parasites.
Additional file 1 of Implementing a flipped classroom model in an evidence-based medicine curriculum for pre-clinical medical students: evaluating learning effectiveness through prospective propensity score-matched cohorts
Creators: name: Tsao, Yen-Po
name: Yeh, Wan-Yu
name: Hsu, Teh-Fu
name: Chow, Lok-Hi
name: Chen, Wei-Chih
name: Yang, Ying-Ying
name: Shulruf, Boaz
name: Chen, Chen-Huan
name: Cheng, Hao-Min
Publisher: name: figshare
Year: 2022
Subjects: Medicine
Pharmacology
Biotechnology
Biological Sciences not elsewhere classified
Cancer
Science Policy

description: Additional file 1: Supplemental Table S1. Oral Test Score Checklist*.
Enantioselective light switch effect of Δ- and Λ-[Ru(phenanthroline)2 dipyrido[3,2-a:2′, 3′-c]phenazine]2+ bound to G-quadruplex DNA
Creators: name: Park, Jin Ha
name: Lee, Hyun Suk
name: Jang, Myung Duk
name: Han, Sung Wook
name: Seog K. Kim
name: Lee, Young-Ae
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: Plant Biology

description: The interaction of Δ- and Λ-[Ru(phen)2DPPZ]2+ (DPPZ = dipyrido[3,2-a:2′, 3′-c]phenazine, phen = phenanthroline) with a G-quadruplex formed from 5′-G2T2G2TGTG2T2G2–3′(15-mer) was investigated. The well-known enhancement of luminescence intensity (the ‘light-switch’ effect) was observed for the [Ru(phen)2DPPZ]2+ complexes upon formation of an adduct with the G-quadruplex. The emission intensity of the G-quadruplex-bound Λ-isomer was 3-fold larger than that of the Δ-isomer when bound to the G-quadruplex, which is opposite of the result observed in the case of double stranded DNA (dsDNA); the light switch effect is larger for the dsDNA-bound Δ-isomer. In the job plot of the G-quadruplex with Δ- and Λ-[Ru(phen)2DPPZ]2+, a major inflection point for the two isomers was observed at x ≈ .65, which suggests a binding stoichiometry of 2:1 for both enantiomers. When the G base at the 8th position was replaced with 6-methyl isoxanthopterin (6MI), a fluorescent guanine analog, the excited energy of 6-MI transferred to bound Δ- or Λ-[Ru(phen)2DPPZ]2+, which suggests that at least a part of both Ru(II) enantiomers is close to or in contact with the diagonal loop of the G-quadruplex. A luminescence quenching experiment using [Fe(CN)6]4- for the G-quadruplex-bound Ru(II) complex revealed downward bending curves for both enantiomers in the Stern–Volmer plot, which suggests the presence of Ru(II) complexes that are both accessible and inaccessible to the quencher and may be related to the 2:1 binding stoichiometry.
Para saber mais além...
Creators: name: Gildenir Carolino Santos
Publisher: name: figshare
Year: 2017
Subjects: subject: 80706 Librarianship
subject: FOS: Media and communications
subject: Library and Information Studies

description: Resenha: CUNHA, Murilo Bastos da. Para saber mais: fontes de informação em ciência e tecnologia. 2.ed. Brasília, DF: Briquet de Lemos, 2016. 235p. ISBN 858563717X (broch.)