cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Origin of Human T-Lymphotropic Virus Type 1 in Rural Côte d’Ivoire
Creators: name: Calvignac, Sébastien
name: Adjogoua, Edgard Valerie
name: Akoua-Koffi, Chantal
name: Hedemann, Claudia
name: Schubert, Grit
name: Ellerbrok, Heinz
name: Leendertz, Siv Aina J.
name: Pauli, Georg
name: Leendertz, Fabian
Publisher: name: Robert Koch-Institut
Year: 2012
Subjects: subject: Animals
subject: Humans
subject: Phylogeny
subject: Simian T-lymphotropic virus 1/genetics
subject: Primates
subject: Terminal Repeat Sequences
subject: Cote d'Ivoire
subject: Genes env
subject: HTLV-I Infections/transmission
subject: Human T-lymphotropic virus 1/genetics
subject: Human T-lymphotropic virus 1/immunology
subject: Simian T-lymphotropic virus 1/immunology
subject: 610 Medizin

description: Simian T-lymphotropic virus type 1 (STLV-1) strains occasionally infect humans. However, the frequency of such infections is unknown. We show that direct transmission of STLV-1 from nonhuman primates to humans may be responsible for a substantial proportion of human T-lymphotropic virus type 1 infections in rural Côte d’Ivoire, where primate hunting is common.
sj-pdf-1-smo-10.1177_20503121211029180 – Supplemental material for Healing below the ankle is possible in patients with diabetes mellitus and a forefoot gangrene
Creators: name: Elgzyri, Targ
name: Apelqvist, Jan
name: Lindholm, Eero
name: Örneholm, Hedvig
name: Annersten Gershater, Magdalena
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: Cardiology
subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine
subject: 110305 Emergency Medicine
subject: 110306 Endocrinology
subject: 110308 Geriatrics and Gerontology
subject: 110904 Neurology and Neuromuscular Diseases
subject: 111099 Nursing not elsewhere classified
subject: 111199 Nutrition and Dietetics not elsewhere classified
subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: 110314 Orthopaedics
subject: 110604 Sports Medicine
subject: 110315 Otorhinolaryngology
subject: 111702 Aged Health Care
subject: 111403 Paediatrics
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 110203 Respiratory Diseases
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology
subject: 110323 Surgery
subject: 70706 Veterinary Medicine
subject: FOS: Veterinary sciences

description: Supplemental material, sj-pdf-1-smo-10.1177_20503121211029180 for Healing below the ankle is possible in patients with diabetes mellitus and a forefoot gangrene by Targ Elgzyri, Jan Apelqvist, Eero Lindholm, Hedvig Örneholm and Magdalena Annersten Gershater in SAGE Open Medicine
What Kind Of Democracy? Which Kind Of Pluralism? Comparing President Ramiz Alia's Meetings With The Intellectuals And With The Student Representation
Creators: name: Krasniqi, Afrim
Publisher: name: Routledge
Year: 2019

description: A central point on which these differences stand out clearly is their understanding of the competitive democratic system. Among the vast number of events, when it comes to the contrasting of the views about democracy and the democratic system, two such events that took place within a few months are particularly important and interesting to compare. One could hardly miss their symbolism and significance, because these events involve the most advanced and the most influential competing visions of the future of Albania at that time. The central figure in both events is the then First Secretary of the Central Committee of the Party of Labor of Albania (PLA) and Chairman of the Presidium of the Popular Assembly, the equivalent of the President, Ramiz Alia. The other sides that interact with President Alia, however, are the two other key groups of players in the transition. In the first meeting are the leading members of the Albanian intelligentsia. In the second meeting the key group are the representatives of the students. The first event, Alia's meeting with the representatives of the intelligentsia, took place on August 12. The second event, Alia's meeting with the Student Representation, took place on December 11th, 1990.

In this chapter I show how the representatives of the intelligentsia in the one instance, and those of the students in the other, represented two different and incompatible interpretations of the past. More importantly, the intellectuals and students offered two competing visions of the future for Albania. More importantly, the students insisted on the transformation of the political system, the establishment of the pluralistic democratic system, and defended these objectives, forcing President Ramiz Alia to accept the change from a one-party system to a multiparty system.
First International External Quality Assessment of Molecular Detection of Crimean-Congo Hemorrhagic Fever Virus
Creators: name: Escadafal, Camille
name: Ölschläger, Stephan
name: Avšič-Županc, Tatjana
name: Papa, Anna
name: Vanhomwegen, Jessica
name: Wölfel, Roman
name: Mirazimi, Ali
name: Teichmann, Anette
name: Mantke, Oliver Donoso
name: Niedrig, Matthias
Publisher: name: Robert Koch-Institut, Biologische Sicherheit
Year: 2012
Subjects: subject: Humans
subject: Virology/methods
subject: International Cooperation
subject: Clinical Laboratory Techniques/standards
subject: Molecular Diagnostic Techniques/methods
subject: Virology/standards
subject: Clinical Laboratory Techniques/methods
subject: Hemorrhagic Fever Crimean/diagnosis
subject: Laboratory Proficiency Testing
subject: Molecular Diagnostic Techniques/standards
subject: Nairovirus/isolation & purification
subject: Quality Assurance Health Care
subject: 610 Medizin

description: Crimean-Congo hemorrhagic fever (CCHF) is a zoonosis caused by a Nairovirus of the family Bunyaviridae. Infection is transmitted to humans mostly by Hyalomma ticks and also by direct contact with the blood or tissues of infected humans or viremic livestock. Clinical features usually include a rapid progression characterized by hemorrhage, myalgia and fever, with a lethality rate up to 30%. CCHF is one of the most widely distributed viral hemorrhagic fevers and has been reported in Africa, the Middle East and Asia, as well as parts of Europe. There is no approved vaccine or specific treatment against CCHF virus (CCHFV) infections. In this context, an accurate diagnosis as well as a reliable surveillance of CCHFV infections is essential. Diagnostic techniques include virus culture, serology and molecular methods, which are now increasingly used. The European Network for the Diagnostics of “Imported” Viral Diseases organized the first international external quality assessment of CCHVF molecular diagnostics in 2011 to assess the efficiency and accurateness of CCHFV molecular methods applied by expert laboratories. A proficiency test panel of 15 samples was distributed to the participants including 10 different CCHFV preparations generated from infected cell cultures, a preparation of plasmid cloned with the nucleoprotein of CCHFV, two CCHFV RNA preparations and two negative controls. Forty-four laboratories worldwide participated in the EQA study and 53 data sets were received. Twenty data sets (38%) met all criteria with optimal performance, 10 (19%) with acceptable performance, while 23 (43%) reported results showing a need for improvement. Differences in performance depended on the method used, the type of strain tested, the concentration of the sample tested and the laboratory performing the test. These results indicate that there is still a need for improving testing conditions and standardizing protocols for the molecular detection of Crimean-Congo hemorrhagic fever virus.
Thirty Years of Political Campaigning in Central and Eastern Europe: Albania
Creators: name: Krasniqi, Afrim
Publisher: name: Palgrave Macmillan Cham
Year: 2020

description: The chapter focuses on the development of political communication and campaigning in Albania. It starts with a brief overview of the basic characteristics of the political and party system. Then, it introduces the main laws and rules the campaigners must comply with. After that, the author describes the evolution of communication tactics and techniques used by parties and candidates to persuade voters to vote for them over the last three decades. At the end of the chapter, the author discusses the most recent campaigning trends in Albania and summarises the chapter.
Lack of Evidence for Schmallenberg Virus Infection in Highly Exposed Persons, Germany, 2012
Creators: name: Ducomble, Tanja
name: Wilking, Hendrik
name: Stark, Klaus
name: Takla, Anja
name: Askar, Mona
name: Schaade, Lars
name: Nitsche, Andreas
name: Kurth, Andreas
Publisher: name: Robert Koch-Institut
Year: 2012
Subjects: subject: Adult
subject: Humans
subject: Female
subject: Germany/epidemiology
subject: Male
subject: Middle Aged
subject: Animals
subject: Occupational Exposure
subject: Sheep Diseases/transmission
subject: Zoonoses/epidemiology
subject: Zoonoses/virology
subject: Antibodies Viral/blood
subject: Animal Husbandry
subject: Bunyaviridae Infections/diagnosis
subject: Bunyaviridae Infections/epidemiology
subject: Bunyaviridae Infections/transmission
subject: Bunyaviridae Infections/veterinary
subject: Orthobunyavirus/classification
subject: Orthobunyavirus/genetics
subject: Orthobunyavirus/immunology
subject: Sheep/virology
subject: Sheep Diseases/diagnosis
subject: Sheep Diseases/epidemiology
subject: Sheep Domestic
subject: 610 Medizin

description: Schmallenberg virus, a novel orthobunyavirus, is spreading among ruminants, especially sheep, throughout Europe. To determine the risk for human infection, we conducted a survey among shepherds to assess possible exposure and symptoms. We also performed serologic and molecular assays. No evidence of transmission to humans was detected.
Simulation of a Natural Gas Steam Reforming Reactor at Different Scales
Creators: name: PUGLIESE, FEDERICO
Publisher: name: Universit� degli studi di Genova
Year: 2020

description: The concept of sustainable energy is often associated to the so-called hydrogen
economy. However, hydrogen cannot be regarded as an energy source, since it is not
present in nature as free H2. Therefore, it must be produced using chemical processes.
Among them, natural gas steam reforming (NGSR) is the most widespread and economically
feasible process. Natural gas (NG) is a mixture with no well-defined and
constant composition. However, methane is the prevailing component (around 85-
90%), but also higher hydrocarbons (i.e. ethane, propane, butane...) can be found.
NGSR involves the proper endothermic reaction of reforming which produces syngas
(a mixture of H2, CO and CO2). Then, the slight exothermic reaction of water gas
shift, further converts CO in CO2 producing more hydrogen. The overall process is
highly endothermic, so requires a large amount of heat. Therefore, the reactors are
tubes placed in a furnace which provides direct heat to the tubes. Even though this
process implements a well-established technology, it still presents some issues, such
as carbon formation and deposition. Usually, a high steam to carbon (S/C) ratio allows
to reduce carbon formation and its deposition: a value of S/C higher than 2.5
is generally believed to be safe for coke-free operation, nevertheless the problem of
carbon formation and deposition is still not solved.
The aim of the first part, is the development of an accurate model for these reactors.
The mathematical model underlying the chemical and physical system is made
of the mass and energy balances. The constitutive equations are then coupled with
the kinetic equations for all the reaction involved in the process. The kinetic equations
for the NGSR process are retrieved from the literature (i.e. Xu and Froment) but, with
a simplified approach, they are adapted to our specific case. The overall set constitutes
a partial differential and algebraic equation (PDAE) system which and requires
boundary conditions which generally are chosen to be flowrate and composition of
the feeding mixture. The resolution of the PDAE system needs the implementation
of a numerical method through a finite element method (FEM), implemented through
COMSOL Multiphysics�. The major problem which has shown up is the numerical
method convergence. However, at the end of the simulation it is possible to obtain
plots and maps of the main physical and chemical quantities of interest.
Furthermore, an experimental analysis of end-of-life commercial catalyst coming
from a full-scale industrial SMR reactor is carried out. This experimental analysis
provides interesting results regarding catalyst structure and the eventual carbon deposition.
Therefore, a possible qualitative explanation for the carbon formation can be
given.
Zidovudine Exposure in HIV-1 Infected Tanzanian Women Increases Mitochondrial DNA Levels in Placenta and Umbilical Cords
Creators: name: Kunz, Andrea
name: Wurmb-Schwark, Nicole Von
name: Sewangi, Julius
name: Ziske, Judith
name: Lau, Inga
name: Mbezi, Paulina
name: Theuring, Stefanie
name: Hauser, Andrea
name: Dugange, Festo
name: Katerna, Angela
name: Harms, Gundel
Publisher: name: Robert Koch-Institut
Year: 2012
Subjects: subject: Adult
subject: Humans
subject: Female
subject: Pregnancy
subject: Male
subject: Infant
subject: Young Adult
subject: HIV Infections/drug therapy
subject: HIV-1/drug effects
subject: HIV-1/physiology
subject: Anti-HIV Agents/therapeutic use
subject: HIV Infections/genetics
subject: Anti-HIV Agents/pharmacology
subject: DNA Mitochondrial/metabolism
subject: HIV Infections/embryology
subject: HIV Infections/metabolism
subject: Placenta/drug effects
subject: Placenta/metabolism
subject: Tanzania
subject: Umbilical Cord/drug effects
subject: Umbilical Cord/metabolism
subject: Zidovudine/pharmacology
subject: Zidovudine/therapeutic use
subject: 610 Medizin

description: Background: Zidovudine (AZT) constitutes part of the recommended regimens for prevention and treatment of HIV-1 infection. At the same time, AZT as well as HIV-1 infection itself may induce mitochondrial damage. In this study, we analyzed the impact of prenatal AZT-exposure on mitochondrial alterations in HIV-infected women and their infants. Methods: Mitochondrial DNA (mtDNA) levels in placentas of HIV-1 infected Tanzanian women with and without prenatal AZT exposure, and in the umbilical cords of their AZT-exposed/unexposed infants were quantified using real-time PCR. Furthermore, we checked for the most common mitochondrial deletion in humans, the 4977 base pair deletion (dmtDNA4977) as a marker for mitochondrial stress. Results: 83 women fulfilled the inclusion criteria. 30 women had been treated with AZT (median duration 56 days; IQR 43–70 days) while 53 women had not taken AZT during pregnancy. Baseline maternal characteristics in the two groups were similar. The median mtDNA levels in placentas and umbilical cords of women (311 copies/cell) and infants (190 copies/cell) exposed to AZT were significantly higher than in AZT-unexposed women (187 copies/cell; p = 0.021) and infants (127 copies/cell; p = 0.037). The dmtDNA4977 was found in placentas of one woman of each group and in 3 umbilical cords of AZT-unexposed infants but not in umbilical cords of AZT-exposed infants. Conclusions: Antenatal AZT intake did not increase the risk for the common mitochondrial deletion dmtDNA4977. Our data suggests that AZT exposure elevates mtDNA levels in placentas and umbilical cords possibly by positively influencing the course of maternal HIV-1 infection.
Online supplementary file 6 - Supplemental material for A Thematic Analysis of Overdose Prevention and Response Efforts in States Experiencing Declines in Rates of Opioid-Involved Overdose Deaths
Creators: name: Robinson, Amber B.
name: Ali, Nida
name: Costa, Olga
name: Rooks-Peck, Cherie
name: Sorensen-Alawad, Amy
name: Ballard, Jonathan
name: Lowerre, Kathryn
name: Fondario, Anna
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, Online supplementary file 6, for A Thematic Analysis of Overdose Prevention and Response Efforts in States Experiencing Declines in Rates of Opioid-Involved Overdose Deaths by Amber B. Robinson, Nida Ali, Olga Costa, Cherie Rooks-Peck, Amy Sorensen-Alawad, Jonathan Ballard, Kathryn Lowerre and Anna Fondario in Public Health Reports
Additional file 9 of Iguratimod suppresses Tfh cell differentiation in primary Sjögren’s syndrome patients through inhibiting Akt/mTOR/STAT3 signaling
Creators: name: Lyu, Taibiao
name: Jiang, Hui
name: Zeng, Liuting
name: Liu, Suying
name: He, Chengmei
name: Luo, Chaowen
name: Qiao, Lin
name: Zhao, Yan
name: Chen, Hua
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Virology

description: Additional file 9: Supplementary Figure S3. Clinical and laboratory improvement in IGU-treated pSS patients.
sj-pdf-1-cps-10.1177_00104140211024290 – Supplemental Material for Technological Risk and Policy Preferences
Creators: name: Gallego, Aina
name: Kuo, Alexander
name: Manzano, Dulce
name: Fernández-Albertos, José
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160607 International Relations
subject: FOS: Political science

description: Supplemental Material, sj-pdf-1-cps-10.1177_00104140211024290 for Technological Risk and Policy Preferences by Aina Gallego, Alexander Kuo, Dulce Manzano and José Fernández-Albertos in Comparative Political Studies
HLA class I-associated diseases with a suspected autoimmune etiology: HLA-B27 subtypes as a model system
Creators: name: Uchanska-Ziegler, Barbara
name: Loll, Bernhard
name: Fabian, Heinz
name: Hee, Chee Seng
name: Saenger, Wolfram
name: Ziegler, Andreas
Publisher: name: Robert Koch-Institut
Year: 2011
Subjects: subject: Ankylosing Spondylitis
subject: Autoimmunity
subject: HLA-B27 subtypes
subject: Heavy chain flexibility
subject: Infrared spectroscopy
subject: Multiple Sclerosis
subject: Peptide binding modes
subject: Micropolymorphisms
subject: T cell selection
subject: X-ray crystallography
subject: 610 Medizin

description: Although most autoimmune diseases are connected to major histocompatibility complex (MHC) class II alleles, a small number of these disorders exhibit a variable degree of association with selected MHC class I genes, like certain human HLA-A and HLA-B alleles. The basis for these associations, however, has so far remained elusive. An understanding might be obtained by comparing functional, biochemical, and biophysical properties of alleles that are minimally distinct from each other, but are nevertheless differentially associated to a given disease, like the HLA-B*27:05 and HLA-B*27:09 antigens, which differ only by a single amino acid residue (Asp116His) that is deeply buried within the binding groove. We have employed a number of approaches, including X-ray crystallography and isotope-edited infrared spectroscopy, to investigate biophysical characteristics of the two HLA-B27 subtypes complexed with up to ten different peptides. Our findings demonstrate that the binding of these peptides as well as the conformational flexibility of the subtypes is greatly influenced by interactions of the C-terminal peptide residue. In particular, a basic C-terminal peptide residue is favoured by the disease-associated subtype HLA-B*27:05, but not by HLA-B*27:09. This property appears also as the only common denominator of distinct HLA class I alleles, among them HLA-B*27:05, HLA-A*03:01 or HLA-A*11:01, that are associated with diseases suspected to have an autoimmune etiology. We postulate here that the products of these alleles, due to their unusual ability to bind with high affinity to a particular peptide set during positive T cell selection in the thymus, are involved in shaping an abnormal T cell repertoire which predisposes to the acquisition of autoimmune diseases.
Banal na Espiritu - synoptic vs John in gospels + St Gregory of Nyssa na ginagawang idolo ang Diyos sa pamamagitan ng pagpapatong ng abstraction sa Diyos at ang dilemma ng espiritu sa loob vs transendental na espiritu at mga himala laban sa pagiging mabun
Creators: name: Peck Jr, Charles
Publisher: name: unknown
Year: 2024
Subjects: subject: Spirituality--Celtic Church
subject: Holy Spirit
subject: Spirituality--Biblical teaching
subject: National characteristics, Philippine
subject: Art, Philippine
subject: Spirituality--Catholic Church
subject: Spirituality--Christianity--Early church
subject: Spirituality--Psychology
subject: Spirituality in art

description: Ang kamalayan at espiritu bilang puwersa
Ang Banal na Espiritu sa mga Ebanghelyo
Ang mga sinoptikong Ebanghelyo, sa pangkalahatan ay may mas kaunting sinasabi tungkol sa Banal na Espiritu kaysa sa ebanghelyo ni Juan. Ang Ebanghelyo ni Marcos ay may pinakamaliit na sasabihin at binanggit ang Banal na espiritu ng anim na beses lamang. Tulad ng lahat ng Ebanghelyo, itinampok ni Marcos ang bautismo ng espiritu bilang tanda ni Jesus. Sa katunayan, iyon ang pinakatampok ng pagsulat ni Marcos tungkol sa Banal na espiritu - na ang gawain ni Kristo ay mas mataas at mas tumpak dahil siya ay nagbautismo sa Banal na Espiritu, hindi lamang sa tubig. Sinasalamin ni Lucas ang sinabi ni Marcos sa Kabanata 24 bersikulo 49: Ang "pangako ng Ama" ay ang bautismo ng Banal na Espiritu." Sinasabi ng 1 Juan 2:27 na "ang pagpapahid na tinanggap ninyo sa kanya ay nananatili sa inyo" (1 Juan 2:27). Ang metapora para sa "bautismo sa Banal na Espiritu" ay naging sa "Kristiyanismo" isang mahalagang aspeto ng "Kristo." Ang metapora ay kinuha ang ideya ng paglilinis ng katawan ng tao sa pamamagitan ng bautismo sa tubig at pinalawak ito sa paglilinis ng espiritu ng tao sa pamamagitan ng bautismo sa Banal na Espiritu.
sj-pdf-1-aan-10.1177_02184923211027790 - Supplemental material for Role of trans-radial band protocols in radial artery occlusion: Randomized trial
Creators: name: Rahman, Nasir
name: Artani, Azmina
name: Baloch, Farhala
name: Artani, Moiz
name: Fatima, Huma
name: Salam, Abdus
name: Ahmed, Sher
Publisher: name: SAGE Journals
Year: 2021
Subjects: Cardiology

description: Supplemental material, sj-pdf-1-aan-10.1177_02184923211027790 for Role of trans-radial band protocols in radial artery occlusion: Randomized trial by Nasir Rahman, Azmina Artani, Farhala Baloch, Moiz Artani, Huma Fatima, Abdus Salam and Sher Ahmed in Asian Cardiovascular & Thoracic Annals
The role of the mycobacterial DNA-binding protein 1 (MDP1) from Mycobacterium bovis BCG in host cell interaction
Creators: name: Kunisch, Ralph
name: Kamal, Elisabeth
name: Lewin, Astrid
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2012
Subjects: subject: Virulence
subject: Tuberculosis
subject: Mycobacterium
subject: Mycobacterial DNA-binding protein 1
subject: MDP1
subject: DNA-binding protein
subject: Histone-like protein
subject: Latency
subject: Granuloma
subject: Host interaction
subject: 610 Medizin

description: Background: Mycobacterium tuberculosis differs from most pathogens in its ability to multiply inside monocytes and to persist during long periods of time within granuloma in a status of latency. A class of proteins called mycobacterial histone-like proteins has been associated with regulation of replication and latency, but their precise role in the infection process has yet to be uncovered. Our study aimed at defining the impact of the histone-like protein MDP1 from M. bovis BCG (mycobacterial DNA-binding protein 1, corresponding to Rv2986c from M. tuberculosis) on early steps of infection. Results: Previously, a BCG (Bacillus Calmette Guérin) strain had been generated by antisense-technique exhibiting reduced MDP1 expression. This strain was now used to analyse the impact of reduced amount of MDP1 on the interaction with human blood monocytes, macrophage lines and PBMC (peripheral blood mononuclear cells). MDP1 was revealed to be required for growth at acidic pH and for intracellular replication in human blood monocytes. Down-regulation of MDP1 resulted in reduced secretion of the cytokine IL-1β by infected human PBMC. In addition, a reduction of MDP1 expression had a major impact on the formation of fused multi-nucleated macrophages. In monocyte preparations from human blood as well as in human and mouse macrophage cell lines, both the percentage of multi-nucleated cells and the number of nuclei per cell were much enhanced when the monocytes were infected with BCG expressing less MDP1. Conclusion: MDP1 from M. bovis BCG affects the growth at acidic pH and the intracellular replication in human monocytes. It furthermore affects cytokine secretion by host cells, and the formation of fused multi-nucleated macrophages. Our results suggest an important role of MDP1 in persistent infection.
Banal na Espiritu - synoptic vs John in gospels + St Gregory of Nyssa na ginagawang idolo ang Diyos sa pamamagitan ng pagpapatong ng abstraction sa Diyos at ang dilemma ng espiritu sa loob vs transendental na espiritu at mga himala laban sa pagiging mabun
Creators: name: Peck Jr, Charles
Publisher: name: Humanities Commons
Year: 2024
Subjects: subject: Holy Spirit
subject: Spirituality--Catholic Church
subject: Spirituality in art
subject: Spirituality--Psychology
subject: Spirituality--Celtic Church
subject: Spirituality--Biblical teaching
subject: Spirituality--Christianity--Early church
subject: Art, Philippine
subject: National characteristics, Philippine

description: Ang kamalayan at espiritu bilang puwersa Ang Banal na Espiritu sa mga Ebanghelyo Ang mga sinoptikong Ebanghelyo, sa pangkalahatan ay may mas kaunting sinasabi tungkol sa Banal na Espiritu kaysa sa ebanghelyo ni Juan. Ang Ebanghelyo ni Marcos ay may pinakamaliit na sasabihin at binanggit ang Banal na espiritu ng anim na beses lamang. Tulad ng lahat ng Ebanghelyo, itinampok ni Marcos ang bautismo ng espiritu bilang tanda ni Jesus. Sa katunayan, iyon ang pinakatampok ng pagsulat ni Marcos tungkol sa Banal na espiritu - na ang gawain ni Kristo ay mas mataas at mas tumpak dahil siya ay nagbautismo sa Banal na Espiritu, hindi lamang sa tubig. Sinasalamin ni Lucas ang sinabi ni Marcos sa Kabanata 24 bersikulo 49: Ang "pangako ng Ama" ay ang bautismo ng Banal na Espiritu." Sinasabi ng 1 Juan 2:27 na "ang pagpapahid na tinanggap ninyo sa kanya ay nananatili sa inyo" (1 Juan 2:27). Ang metapora para sa "bautismo sa Banal na Espiritu" ay naging sa "Kristiyanismo" isang mahalagang aspeto ng "Kristo." Ang metapora ay kinuha ang ideya ng paglilinis ng katawan ng tao sa pamamagitan ng bautismo sa tubig at pinalawak ito sa paglilinis ng espiritu ng tao sa pamamagitan ng bautismo sa Banal na Espiritu.
Ghrelin and its analogs in muscle diseases
Creators: name: AGOSTI, EMANUELA
Publisher: name: Universit� degli Studi del Piemonte Orientale Amedeo Avogadro
Year: 2018

description: Acylated and unacylated ghrelin (AG and UnAG) are circulating peptide hormones generated by the ghrelin gene mainly in the stomach in consequence of fasting or caloric restriction. AG, through binding to growth hormone secretagogue receptor type 1a (GHSR1a), induces strong release of growth hormone (GH) and other central and peripheral activities. UnAG is not able to bind and activate GHSR1a but features several biological functions, such as improvement of insulin sensitivity in skeletal muscle and enhancement of skeletal muscle regeneration induced by hindlimb ischemia. Moreover, it has been demonstrated that both peptides share common activities, mediated by an unknown receptor, on skeletal muscle where they protect against atrophy and promote proliferation and fusion of myoblast. Giving the multiple activities of this hormone on skeletal muscle, we assessed involvement of ghrelin in muscle regeneration, cachexia and sarcopenia. We showed that UnAG enhances SCs function and stimulates Par polarity complex/P38-mediated asymmetric division, sustaining both SCs self-renewal and myoblast differentiation. We also showed that upregulation of plasmatic levels of UnAG results in an improvement of pathologic phenotype and in the ablation of self-renewal defect of dystrophin-null SCs with a consequent preservation of SCs pool in the later stage of the pathology. Moreover, we show that ghrelin analogs recognize the alternative receptor and protect against cytokines-induced skeletal muscle atrophy. We demonstrate that anamorelin protects against fasting-induced adipose tissue loss without inhibiting muscle wasting in WT mice. Finally, preliminary data show that upregulation of UnAG improves muscle functionality and slightly protects against muscle atrophy and intramyocellular fat deposition. Surprisingly, deletion of ghrelin gene differently affects muscle function, weight, food intake and glucose metabolism, indicating an important role of ghrelin during the aging process.
ORGANIZZAZIONE DEL CITOSCHELETRO, ESPRESSIONE EDISTRIBUZIONE INTRACITOPLASMATICA DI STAUFEN(RNA-BINDING PROTEIN) E CALRETICULINA IN OVOCITIUMANI DURANTE IL PROCESSO MATURATIVO
Creators: name: DE SANTIS, LUCIA
Publisher: name: Universit� degli Studi di Milano
Year: 2013

description: Before the mammalian oocyte engages in the fertilization process, it must acquire an array of molecular and cellular assets defining its developmental potential. These properties specify competencies to complete meiosis and initiate mitosis. Meiotic maturation requires the acquisition both of nuclear and cytoplasmic competence and this complex mechanism involves most of the organelles, the cytoskeleton and molecules that are relocated from the nucleus to the cytoplasm. Messenger RNAs of maternal origin are accumulated in the oocyte throughout its growth in the ovary. These transcripts are then shuttled to specific sites of the ooplasm, where local translation is promoted. The oocyte maturation marks the beginning of this phase of activation of maternal transcripts and proteins and involves the "unmasking" of maternal mRNA concomitantly to post-translational changes of stored proteins. This process loosens the stabilization mechanisms that had been imposed during oogenesis. At the end of this route maternal information will be available to the developing embryo. In this scenario, Staufen RNA Binding Protein may play an important role in the light of its function of vector of mRNAs from the nucleus to the sites of translation. Therefore, we hypothesized that Staufen is expressed during oocyte maturation and that the localization of Staufen protein changes during the meiotic transition from GV to MII. We also postulated that the pattern of Staufen distribution reflects its physical interaction with the endoplasmic reticulum, an organelle directly involved in the process of mRNA translation whose relocalization is central to the process of oocyte maturation. To test the above hypotheses, we assessed the expression of Staufen and Calreticulin (CALR), the latter adopted as a marker of the endoplasmic reticulum, in human oocytes at different stages of maturation: GV, MI and MII. The oocytes were obtained from supernumerary material of assisted reproductive cycles and were subjected to polymerase chain reaction in order to investigate the expression of Staufen, CALR and related RNAs. The corresponding protein products were identified by immunofluorescence and confocal laser scanning microscopy. Our findings indicate that Staufen and CALR are constantly expressed and selectively localized during oocyte maturation. The different pattern of Staufen distribution at the GV, MI and MII stages implicates that localization of protein translation is one of the levels at which gene expression is regulated in the maturing oocyte. On the other hand, localization of CALR at the MII stage reveals novel aspects of physical interaction with the MII spindle and suggests a previously unrecognised role of the endoplasmic reticulum in support of cytoskeletal function in the human oocyte.
Application of a split luciferase complementation assay for the detection of viral protein–protein interactions
Creators: name: Deng, Qiji
name: Wang, Dan
name: Xiang, Xiaoxiao
name: Gao, Xiaofei
name: Hardwidge, Philip R.
name: Kaushik, Radhey S.
name: Wolff, Thorsten
name: Chakravarty, Suvobrata
name: Li, Feng
Publisher: name: Robert Koch-Institut
Year: 2011
Subjects: subject: Viral disease
subject: Protein–protein interaction
subject: Split luciferase complementation assay
subject: 610 Medizin

description: Intraviral protein-protein interactions are critical for virus survival in the host. Discovery of such interactions is important to understand molecular mechanisms of viral replication and pathogenesis. The development of a cell-based assay that can be employed to examine systematically viral protein interactions is described. The method, known as the split luciferase complementation assay (SLCA), is based on the principle that N- and C-terminal domains of luciferase alone do not emit luminescence; however, if fused to interacting proteins the two non-functional halves can be brought into close enough proximity through a specific protein-protein interaction to restore the functions of the enzyme and emit detectable light. The well-studied influenza B polymerase acidic protein (PA) and basic protein 1 (PB1) interaction was used as a model system to develop the assay. Consistent with previous studies, a strong PA-PB1 interaction was demonstrated in the assay. The PA-PB1 interaction was also disrupted by single amino acid mutations in the N-terminal domain of PB1 that is responsible for binding PA. The described SLCA is highly specific and easy to perform, and thus may be useful for studying protein-protein interactions in viral diseases.
EHEC O104:H4 in Germany 2011: Large outbreak of bloody diarrhea and haemolytic uraemic syndrome by shiga toxin-producing E. coli via contaminated food
Creators: name: Burger, Reinhard
Publisher: name: Robert Koch-Institut
Year: 2012
Subjects: subject: EHEC O104:H4
subject: 610 Medizin

description: In the summer of 2011 Germany experienced one of the largest outbreaks of a food-borne infection caused by enterohaemorrhagic Escherichia coli (EHEC) with the serotype O104:H4. A large number of cases with bloody diarrhea and haemolytic uraemic syndrome (HUS) occurred. Never before was such a high rate of HUS cases observed in an outbreak caused by a food-borne pathogen. The events in Germany caused by EHEC O104:H4 in the summer of 2011 show dramatically how rapidly an infectious agent is able to develop into a major health threat for a whole country. The outbreak caused widespread concern among the population, turning soon into fear. People expecting safe and healthy food felt threatened. It changed the eating habits of the majority of the population, and it had enormous economic consequences, particularly for farmers producing salad ingredients. It resulted in a large number of seriously ill patients and in a substantial number of deaths. The burden of disease and the economic consequences have made it a tragedy for many. It is important to analyse this outbreak scientifically in order to learn from this unique event and to be prepared for comparable infections in the future. In particular, all the steps regarding detection of cases, diagnostic procedures, identification of vehicle and origin, and infection control measures, all the way to therapy, should be reflected carefully. Usually, even experienced physicians encounter only a few cases of EHEC-induced HUS in adults in their whole career. Therefore, the large number of cases in Germany represents a valuable source of information for future epidemics. This manuscript summarises the work of the HUS investigation team of the Robert Koch Institute (RKI) and gives an overview of the work done by the colleagues in the Department of Infectious Disease Epidemiology at the RKI (G. Krause, C. Frank, D. Werber, K. Stark, and U. Buchholz), the Department for Infectious Diseases (M. Mielke and A. Fruth), and the RKI-Consultant Laboratory for HUS/EHEC at the University of Münster (H. Karch). Many additional colleagues were involved.
How To Be A Pirate: An Interview with Alexandra Elbakyan and Gary Hall by Holger Briel
Creators: name: Elbakyan, Alexandra
name: Hall, Gary
Publisher: name: Liverpool University Press
Year: 2023
Subjects: subject: Humanities
subject: FOS: Humanities
subject: Critical theory
subject: Piracy
subject: Library science
subject: Copyright
subject: Open scholarship
subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: Mass media
subject: Open access publishing
subject: Intellectual life

description: From the opening: 'When Michael, Markus, and I first discussed the idea for publishing
this book, it was very clear to us that we did not want to write yet
another theoretical book on Internet piracy; practitioners from the
field should also have a voice. After all, it is they who created this
phenomenon in the first place and it is clearly grassroots-driven.
In the following, two eminent actors in the field of Internet piracy
will discuss their views on file sharing, piracy, and politics (of
resistance).'
NướcGPT: Decoding Salinity Intrusion for Mekong Delta
Creators: name: Nguyen, Trang TH
name: Phan, Trung T
name: Pham, Hang
name: Do, Minh
name: Phan, Lan
name: Dinh, Tuan
name: Vo, Tue
Publisher: name: Gates Open Research
Year: 2025

description: This blog post highlights NướcGPT, Vietnam’s first multilingual climate chatbot, designed to support farmers and policymakers facing severe salinity intrusion in the Mekong Delta. Developed by Fulbright University and Nuoc Solutions, it leverages LLMs to democratise climate data and bridge accessibility gaps in underserved, climate-vulnerable regions.
Additional file 10 of Iguratimod suppresses Tfh cell differentiation in primary Sjögren’s syndrome patients through inhibiting Akt/mTOR/STAT3 signaling
Creators: name: Lyu, Taibiao
name: Jiang, Hui
name: Zeng, Liuting
name: Liu, Suying
name: He, Chengmei
name: Luo, Chaowen
name: Qiao, Lin
name: Zhao, Yan
name: Chen, Hua
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Virology

description: Additional file 10: Supplementary Figure S4. Correlation analysis of Tfh cells with B cells and ESSDAI in IGU-treated pSS patients.
Regional differences in body fat distributions among people with comparable body mass index: a comparison across six German population-based surveys
Creators: name: Stang, Andreas
name: Döring, Angela
name: Völzke, Henry
name: Moebus, Susanne
name: Greiser, Karin Halina
name: Werdan, Karl
name: Berger, Klaus
name: Ellert, Ute
name: Neuhauser, Hannelore
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2011
Subjects: subject: Humans
subject: Female
subject: Germany/epidemiology
subject: Male
subject: Middle Aged
subject: Body Mass Index
subject: Population Surveillance
subject: Risk Factors
subject: Risk Assessment
subject: Aged
subject: Time Factors
subject: Linear Models
subject: Cardiovascular Diseases/mortality
subject: Cardiovascular Diseases/physiopathology
subject: Adiposity
subject: Cardiovascular Diseases/epidemiology
subject: Health Status Disparities
subject: Residence Characteristics
subject: Waist Circumference
subject: Waist-Hip Ratio
subject: 610 Medizin

description: Introduction: The mortality of circulatory diseases of the German population varies considerably across regions. The comparison of the regional distributions of cardiovascular risk factors can provide clues to the reasons for cardiovascular mortality differences. The aim of this study was to determine whether indirect measures of fat distribution within subgroups of comparable body mass indices (BMIs) differ by region in Germany. Methods: We included six German population-based epidemiological studies conducted between 1997 and 2006 that included a detailed assessment of anthropometric measures including overall 15 215 people aged 45–74 years. We calculated mean values of BMI, waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR). We estimated mean regional differences of WC, HC, and WHR within narrow ranges of BMI. Results: BMI distributions across the study populations were very similar. However, body fat distributions as measured by WC within subgroups of similar BMIs differed considerably across regions. For example, among people with a BMI of 24.0–25.9, estimated WCs were on average 3.4 and 6.7 cm higher among men and women in Saxony-Anhalt than among men and women in Bavaria, respectively. Conclusion: We provide evidence that the BMI distributions across six population-based surveys in Germany are very similar and that body fat distributions among people with comparable BMIs show relevant regional differences. Our observed WC differences might contribute to regional cardiovascular disease risk differences in Germany. Our findings may trigger further similar analyses across European populations to explain large area variations of cardiovascular disease burden.
‘How To Be A Pirate: An Interview with Alexandra Elbakyan  and Gary Hall by Holger Briel’
Creators: name: Elbakyan, Alexandra
name: Hall, Gary
Publisher: name: Humanities Commons
Year: 2023
Subjects: subject: Open access publishing
subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: Critical theory
subject: Library science
subject: Mass media
subject: Copyright
subject: Piracy
subject: Open scholarship
subject: Intellectual life
subject: Humanities
subject: FOS: Humanities

description: From the opening: 'When Michael, Markus, and I first discussed the idea for publishing this book, it was very clear to us that we did not want to write yet another theoretical book on Internet piracy; practitioners from the field should also have a voice. After all, it is they who created this phenomenon in the first place and it is clearly grassroots-driven. In the following, two eminent actors in the field of Internet piracy will discuss their views on file sharing, piracy, and politics (of resistance).'
Additional file 1 of Improving furfural tolerance in a xylose-fermenting yeast Spathaspora passalidarum CMUWF1–2 via adaptive laboratory evolution
Creators: name: Saengphing, Thanyalak
name: Sattayawat, Pachara
name: Kalawil, Thitisuda
name: Suwannarach, Nakarin
name: Kumla, Jaturong
name: Yamada, Mamoru
name: Panbangred, Watanalai
name: Rodrussamee, Nadchanok
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Evolutionary Biology
subject: Ecology
subject: Biological Sciences not elsewhere classified

description: Supplementary Material 1
Single mutations in the transmembrane envelope protein abrogate the immunosuppressive property of HIV-1
Creators: name: Morozov, Vladimir
name: Morozov, Alexey V.
name: Semaan, Marwan
name: Denner, Joachim
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2012
Subjects: subject: HIV
subject: Immunosuppression
subject: Pathogenesis
subject: Transmembrane envelope protein
subject: gp41
subject: Cytokine release
subject: 610 Medizin

description: Background: The mechanism by which HIV-1 induces AIDS is still unknown. Previously, synthetic peptides corresponding to the conserved immunosuppressive (isu) domain in gp41 of HIV-1 had been shown to inhibit proliferation and to modulate cytokine expression of immune cells. The question is, whether the viral gp41 can do the same. Results: We show for the first time that two trimeric forms of glycosylated gp41 released from transfected human cells modulated expression of cytokines and other genes in human PBMCs in the same manner, but at least seven hundred-fold stronger compared to that induced by the isu peptide. Single amino acid substitutions in the isu domain of gp41 introduced by site-directed mutagenesis abrogated this property. Furthermore, replication-competent HIV-1 with a mutation in the isu domain of gp41 did not modulate the cytokine expression, while wild-type virus did. Interestingly, most of the abrogating mutations were not reported in viral sequences derived from infected individuals, suggesting that mutated non-immunosuppressive viruses were eliminated by immune responses. Finally, immunisation of rats with gp41 mutated in the isu domain resulted in increased antibody responses compared with the non-mutated gp41. These results show that non-mutated gp41 is immunosuppressive in immunisation experiments, i.e. in vivo, and this has implications for the vaccine development. Conclusions: These findings indicate that the isu domain of gp41 modulates cytokine expression in vitro and suppresses antibody response in vivo and therefore may contribute to the virus induced immunodeficiency.
Dietary patterns are associated with cardiometabolic risk factors in a representative study population of German adults
Creators: name: Heidemann, Christin
name: Scheidt-Nave, Christa
name: Richter, Almut
name: Mensink, Gert
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2011
Subjects: subject: Germany
subject: Dietary patterns
subject: Dietary surveys
subject: Metabolic syndrome
subject: 610 Medizin

description: Studies that investigated complex actual eating behaviours of the general population and their relation to cardiometabolic risk markers are sparse. We aimed to identify dietary patterns within a nationally representative sample of 4025 German adults by factor analysis based on validated dietary history interviews. Furthermore, we evaluated associations of the derived dietary patterns with abnormalities clustered within the metabolic syndrome and related metabolic markers by logistic regression models and ANCOVA. A high adherence to the ‘processed foods’ pattern reflected a high intake of refined grains, processed meat, red meat, high-sugar beverages, eggs, potatoes, beer, sweets and cakes, snacks and butter, whereas a high adherence to the ‘health-conscious’ pattern represented a high intake of vegetables, vegetable oils, legumes, fruits, fish and whole grains. For subjects in the highest compared with those in the lowest quintile of the processed foods pattern, the occurrence of abdominal obesity was 88 (95 % CI 31, 169) % higher, hypertension was 34 (95 % CI − 4, 86) % higher, hypertriacylglycerolaemia was 59 (95 % CI 11, 128 ) % higher and the metabolic syndrome was 64 (95 % CI 10, 143) % higher when adjusted for age, sex, energy intake, socio-economic status, sport activity and smoking. Furthermore, subjects in the highest quintile had statistically significantly higher uric acid concentrations and lower folate concentrations (P for trend < 0·05). In contrast, subjects in the highest quintile of the health-conscious pattern had a 30 (95 % CI 10, 46) % lower occurrence of hypertension, higher folate concentrations and lower homocysteine and fibrinogen concentrations (P for trend < 0·05). These data strengthen the findings from non-representative studies and emphasise the importance of healthy overall food patterns for preventing metabolic disturbances.