cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The influence of vegetative windbreaks on fugitive dust (PM10) mitigation and transport flux: the role of turbulence in enhancing particulate deposition
Creators: name: Moran, Sean
Publisher: name: University of Utah
Year: 2012
Subjects: Deposition
Environmental fluid dynamics
Hot-wire anemometry
Turbulence
Wind tunnel

description: Quantifying deposition efficiency for fugitive dust on vegetation is essential for developing more accurate computational models. This work focuses on the role that turbulent motions play in deposition enhancement. This research combines field and wind tunnel experiments to study particle deposition onto vegetation resulting from small-scale interactions of turbulent flows. These experiments will help to optimize the design of vegetative windbreaks as a mitigation tool for fugitive dust removal from the atmosphere. The long-term goal is to use these data for model development and parameterization within the Quick Urban and Industrial Complex (QUIC) dispersion modeling system. Experimental testing in a full scale wind tunnel seeks to quantify deposition efficiencies by varying the relevant Stokes number parameters (i.e., wind speed, deposition area of substrate, and particle size). Experimental results indicated that grid induced turbulence enhances deposition in all six directions (x-upstream and downstream, y-right and left, z-up and down). Deposition was enhanced on the upstream impaction surface (-x direction) by a factor of two compared to the no-grid "laminar" case. Deposition on all other directional surfaces increased by about an order of magnitude. This work investigates the effect of isotropic turbulence on the enhancement of particle deposition to surfaces for inertial impaction dominated processes. Turbulence and particle deposition were quantified using hot-wire anemometry and fluorimetry measurement techniques, respectively. The contribution of turbulence on deposition is shown to scale with a dimensionless parameter formed from the combination of the classical Stokes number (Stk) and the Taylor-microscale Reynolds number (Rλ). This scaling helps to understand the role that the intermediate eddies (λ) and turbulent fluctuations (u') have on deposition fraction (DFλ). A modified Stokes number (Stk*=Stk·Rλ 0.3) parameterization for an empirical equation (DFλ = 100-100/(440.5·(Stk*)3.88+1)) was devised to utilize this new scaling and incorporate physically significant turbulent deposition parameters (i.e., λ and u') into the solution. Experimental results indicate that past impaction parameterizations substantially underestimate deposition in the presence of turbulence.
Sonnenfleckenzeichnung Nr. 23340.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 09.05.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Theoretical studies of mechanisms of epoxy curing systems
Creators: name: Pham, My-Phuong
Publisher: name: University of Utah
Year: 2012
Subjects: Epoxy
Curing

description: The epoxy resin market is faced with an ever increasing demand for a "designer" range of properties for the epoxy end-use products. Therefore, it is necessary to obtain a complete mechanism and accurate kinetic model that has predictive capabilities. This dissertation addresses the issue in two sections.  The first section is an analysis of systematic theoretical studies on the mechanisms of four main curing reactions, epoxy-amine, epoxy-phenol, epoxy-acid and epoxy-anhydride, at the molecular-level using B3LYP density functional theory. The strength of these mechanistic models is their ability to extrapolate to different reactions that use a particular epoxy resin, a particular curing agent and/or a particular catalyst. The examination of all possible reaction pathways for each curing system can allow us to predict the most preferable pathway in the system and can enable the development of a more accurate kinetic model for the system. In addition, it provides insight into the role of tertiary amines in catalyzing the curing reaction.  The second section involves the development of a new kinetic model for the epoxy-amine curing system guided by quantum chemistry calculations. This accurate kinetic model for an epoxy-amine curing system has the potential to be applied to other curing systems, solving successfully an industrial issue by quantum chemistry calculation.
Visual exploration of large traffic database using traffic cubes
Creators: name: Song, Ying
Publisher: name: University of Utah
Year: 2012
Subjects: Traffic flow
Computer simulation

description: Advances in data collection tools and computation abilities result in a  significant increase of capabilities for both collecting and generating data. The  consequent growth of available data generates an urgent need for techniques to transform  the massive amount of collected data into useful information.  This thesis develops traffic-cube based visualization techniques, and  demonstrates the efficiency of those techniques as an approach of mining traffic flow  data. The basis of these techniques is a data mining technique known as data cube, which  is an array of values defined across multiple measurement dimensions that allows rapid,  user-interactive aggregation and cross-tabulations of data. The traffic cube is an extension  of the data cube that facilitates these operations and is usually used to organize and  manage traffic flow data. In this thesis, the traffic cube is defined by three dimensions:  the clock time (T), the calendar date (D), and the spatial location (S) of the recorded  traffic count. For each dimension, a hierarchy is designed for data aggregation; and we  visualize the aggregated two-dimensional slices of the original traffic data cube to extract  useful information about traffic situation.
Sonnenfleckenzeichnung Nr. 23398.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 10.07.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Evaluation of knee joint stresses during kneeling work
Creators: name: Jampala, Sree Harsha
Publisher: name: University of Utah
Year: 2012
Subjects: Force sensor
Kneeling work
Kneepads
Oesteoarthritis
Knee joint stresses

description: Kneeling is a daily activity for some occupations like carpet layers, miners, tile layers, floor layers, electricians, shipbuilders and many others. Several studies have shown that there is an association between kneeling or squatting and development of osteoarthritis of the knee joint. Even though this relationship has been established, few research studies have been conducted to estimate actual knee stresses and the role of  kneepads in reducing these stresses while kneeling. Hence, this study looks at estimating the stress on the knees during simulated kneeling work while wearing six different types of kneepads. Custom force sensors were fabricated using FlexiForce™ Sensors and were placed on both knees over anatomically defined landmarks on the patella and tibial tubercle. Ten participants were recruited and consented to perform a series of kneeling tasks. Five wooden platforms were placed in five different locations surrounding two force plates and custom made three-axis load cells where the participants knelt. A set of five lettered, ceramic tiles were given to each participant and randomly placed on each platform with a corresponding letter. Estimated kneeling reaction forces derived from sensor values were used to quantify the effectiveness of each design in reducing the applied forces on the knee joint. Also these forces were used to verify the significance of location on force. The data from both the sensors and the force plates and load cells were  analyzed for results. Two-way analysis of variance (ANOVA) with repeated measures, where kneepad and location were the independent variables and calculated applied force was the independent variable was used to analyze the results. There was a significant relationship between force and kneepad and also between force and location. The placement of the sensor on the knee was found to be a major factor for the estimation of the force on the knees. It is apparent that proper kneepad design and selection can be an effective abatement to reduce the stress accumulated on the knee during kneeling work.
Tosse: Uma Preocupação? Perspetiva dos Pais
Creators: name: Martins, Marta
name: Cardosa, Maria Filomena
name: Almeida, Marta
name: Marques, Rita
name: Nunes, Filipa
name: Pinto, Margarida
name: Braga, Manuela
Publisher: name: Portuguese Journal of Pediatrics
Year: 2018

description: Introdução: A tosse é um dos sintomas mais comuns em idade pediátrica. O recurso a fármacos é frequente, apesar da sua eficácia e segurança não estarem comprovadas. O objetivo deste estudo foi compreender a perspetiva que os cuidadores têm da tosse e descrever as medidas terapêuticas mais utilizadas. Métodos: Estudo transversal e observacional, que decorreu de fevereiro a abril de 2016, através da aplicação de um questionário a uma amostra de cuidadores de crianças admitidas na urgência pediátrica de um hospital de nível II. Resultados: Foram recolhidas 220 respostas. Quase todos os participantes eram pais (94%), do sexo feminino (82%), com idade média de 37 anos. Dois terços tinham o ensino secundário ou ensino superior. A maioria dos cuidadores (63%) considerou a tosse um mecanismo de defesa, embora tenham admitido ficar muito preocupados quando o seu filho tosse (56%). Mais de metade dos cuidadores (56%) admitiu ter administrado fármacos para a tosse no último Inverno, dos quais 62% foram prescritos por um médico. A utilização de fármacos foi maior nos pais com menor grau de instrução. A maioria dos pais considerou terem sido eficazes (72%) e apenas um terço os considerou como potencialmente perigosos. Discussão: Este estudo sugere que a tosse é um sintoma ainda mal compreendido pelos pais, levando a uma utilização frequente de fármacos. Verificou-se igualmente uma elevada prescrição médica. Destaca-se a importância da formação dos profissionais de saúde e dos pais para uma melhor abordagem da tosse na criança.
description: Portuguese Journal of Pediatrics, Vol. 49 No. 2 (2018)
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 20.08.1970, erstellt von E. Kempfova am Observatorium Hurbanovo, Komarno
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage am Slovenska Ustredna Hvezdaren Observatorium in Hurbanovo, Tschechoslowakei. Später wurden ergänzende Angaben aufgrund weiterer Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Instrument: unbekannt
Dual-functionalized liposome by co-delivery of paclitaxel with sorafenib for synergistic antitumor efficacy and reversion of multidrug resistance
Creators: name: Lei, Meng
name: Ma, Guanglan
name: Sha, Sijia
name: Wang, Xueyuan
name: Feng, Haiting
name: Zhu, Yongqiang
name: Du, Xiao
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Multidrug resistance (MDR) remains one of the major reasons for inefficiency of many chemotherapeutic agents in cancer therapy. In this study, a D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) and polylysine-deoxycholic acid copolymer (PLL-DA) co-modified cationic liposome coating with hyaluronic acid (HA) was constructed for co-delivery of paclitaxel (PTX) and chemosensitizing agent, sorafenib (SOR) to treat the MDR cancer. The multifunctional liposome (HA-TPD-CL-PTX/SOR) presented good stability against rat plasma and was capable of reversing surface zeta potential under acidic conditions in the presence of HAase. Additionally, experimental result confirmed that the PLL-DA copolymer would facilitate the endo-lysosomal escape of the liposome. In vitro study demonstrated that HA-TPD-CL-PTX/SOR could significantly enhance drug accumulation in resistant MCF-7/MDR cells by inhibiting the P-gp efflux, and effectively inhibited growth of tumor cells. Furthermore, the liposome showed an enhanced anticancer activity in vivo, with a tumor growth inhibition rate of 78.52%. In summary, HA-TPD-CL-PTX/SOR exhibited a great potential for effective therapy of resistant cancers by combining with chemotherapeutic agents and could be a promising nano-carrier for reversing MDR and improving the effectiveness of chemotherapy.
The effect of in-group and out-group persuasive communications about climate change on the environmental beliefs and behavioral intentions of winter recreationists
Creators: name: Sarnoff, Philip J.
Publisher: name: University of Utah
Year: 2013
Subjects: Climate change
Elaboration Likelihood Model
Social identity
Winter recreation

description: Climate change has become a ubiquitous topic in society. The majority of the scientific community has concluded that climate change is occurring and that humans are primarily responsible. However, there is less agreement among the general public. Within the winter recreation industry, inconsistent precipitation and higher global surface temperatures associated with climate change have the potential to be problematic. There is a need to effectively influence beliefs about climate change and the behavioral intentions of individuals for those who have an interest in preserving climatic conditions favorable for winter recreation. Persuasive messaging has the potential to leverage an individual's involvement in and social identity with winter recreation activities. This study examined the impact of socially relevant persuasive message sources on the environmental beliefs and behavioral intentions of winter recreationists. This research is presented in a three article dissertation format. The first article addresses a preliminary pilot study developed to test persuasive messages about climate change using criteria outlined in the Elaboration Likelihood Model (ELM). This study tested strong and weak messages to determine the ELM's effectiveness using the real-world issue of climate change. The messages did not meet the established criteria, confirming the difficulties previously identified with applying the ELM to issues in an applied, nonlaboratory setting. The purpose of the second article was to determine the most effective communicator of climate change messages in order to elicit changes in environmental belief and behavioral intention. This study assessed participant environmental beliefs and behavioral intentions in three message treatment groups (in-ski resort source, ski equipment manufacturer source, climate scientist source) and a control group (no message) while accounting for leisure involvement and social identity. An analysis of variance yielded no significant main or interaction effects. Manipulation checks yielded higher cognitive processing and source credibility for the climate science message source. The third article was a practical application on current climatic conditions, perceptions of the general public and winter recreationists, and implications of climate change for winter recreation. In addition, this article proposes actions for the winter recreation industry in order to help mitigate the effects of climate change. The culminating discussion is a reflection on the findings of all three articles. Recommendations include development of more comprehensive messaging strategies surrounding climate change and a more thorough evaluation of the ELM when applied in nonlaboratory settings.
Sonnenfleckenzeichnung Nr. 23386.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 28.06.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Tosse Convulsa: Experiência de uma Unidade de Cuidados Intensivos Pediátricos
Creators: name: Fernandes, Ana SC
name: Boto, Leonor
name: Rios, Joana
name: Camilo, Cristina
name: Abecasis, Francisco
name: Vieira, Marisa
Publisher: name: Portuguese Journal of Pediatrics
Year: 2018

description: Introdução: Apesar de programas de vacinação bem estabelecidos, a tosse convulsa tem reemergido em vários países, particularmente em pequenos lactentes suscetíveis a doença grave. Pretende-se caracterizar os internamentos por tosse convulsa numa unidade de cuidados intensivos pediátricos. Métodos: Estudo descritivo retrospetivo, por análise de processos clínicos de crianças com tosse convulsa confirmada laboratorialmente, internadas na unidade de cuidados intensivos pediátricos de um hospital de nível III entre janeiro de 2008 e julho de 2016. Resultados: Registaram-se 23 internamentos, mediana de idade 40 dias, 14/23 (60,9%) do sexo feminino, 21/23 (91,3%) não imunizados para Bordetella pertussis. A tosse paroxística (100%) e a apneia (69,6%) foram os sintomas definidores de caso mais frequentes. Os principais motivos de internamento foram episódios de cianose e hipoxemia (22/23, 95,7%), bradicardia (17/23, 73,9%) e apneia (16/23, 69,6%). Quinze doentes (65,2%) necessitaram de suporte ventilatório, invasivo em 10. Foi utilizada hipercapnia permissiva em cinco doentes e curarização em quatro. Verificou-se leucocitose em todos os doentes (mediana 26600 células/mL, 15 020-103 900 células/mL). Não foram usadas técnicas leucorredutoras. Identificaram-se agentes coinfetantes em 10 doentes e imagem radiológica de pneumonia em 14, nosocomial em três. Registaram-se cinco casos de hiponatremia e um de convulsões. Não se verificaram óbitos. Discussão: A taxa de complicações e morbimortalidade foi menor do que a reportada noutras séries. O rastreio atempado e tratamento da coinfecção, bem como a estratégia de ventilação utilizada, recorrendo por vezes a curarizantes para prevenir barotrauma, poderão ter contribuído para estes resultados.
description: Portuguese Journal of Pediatrics, Vol. 49 No. 2 (2018)
Active pulmonary targeting against tuberculosis (TB) via triple-encapsulation of Q203, bedaquiline and superparamagnetic iron oxides (SPIOs) in nanoparticle aggregates
Creators: name: Poh, Wilson
name: Rahman, Nurlilah Ab
name: Ostrovski, Yan
name: Sznitman, Josué
name: Pethe, Kevin
name: Loo, Say Chye Joachim
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Tuberculosis (TB) has gained attention over the past few decades by becoming one of the top ten leading causes of death worldwide. This infectious disease of the lungs is orally treated with a medicinal armamentarium. However, this route of administration passes through the body’s first-pass metabolism which reduces the drugs’ bioavailability and toxicates the liver and kidneys. Inhalation therapy represents an alternative to the oral route, but low deposition efficiencies of delivery devices such as nebulizers and dry powder inhalers render it challenging as a favorable therapy. It was hypothesized that by encapsulating two potent TB-agents, i.e. Q203 and bedaquiline, that inhibit the oxidative phosphorylation of the bacteria together with a magnetic targeting component, superparamagnetic iron oxides, into a poly (D, L-lactide-co-glycolide) (PDLG) carrier using a single emulsion technique, the treatment of TB can be a better therapeutic alternative. This simple fabrication method achieved a homogenous distribution of 500 nm particles with a magnetic saturation of 28 emu/g. Such particles were shown to be magnetically susceptible in an in-vitro assessment, viable against A549 epithelial cells, and were able to reduce two log bacteria counts of the Bacillus Calmette-Guerin (BCG) organism. Furthermore, through the use of an external magnet, our in-silico Computational Fluid Dynamics (CFD) simulations support the notion of yielding 100% deposition in the deep lungs. Our proposed inhalation therapy circumvents challenges related to oral and respiratory treatments and embodies a highly favorable new treatment regime.
Sonnenfleckenzeichnung Nr. 23335.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 04.05.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Canadian Gallup Poll # 503-1
Creators: name: Inc., The Canadian Gallup Poll
Publisher: name: Roper Center for Public Opinion Research
Year: 2020

description: Federal election vote intent(1); past federal elections vote(1); satisfaction with the direction Canada is going(2); selling beer and wine in the province(4); tuna fish issue(2); greatest threat to Canada: big business, labor or government(1); best choice for Prime Minister(1); church/synagogue attendance(1). Note: Demographics(17).
Sonnenfleckenzeichnung Nr. 23446.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 03.09.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen
Défice Sintomático Transitório de Zinco: A Propósito de um Caso Clínico
Creators: name: Milheiro Silva, Tiago
name: Machado, Rita
name: Cordeiro, Ana Isabel
Publisher: name: Portuguese Journal of Pediatrics
Year: 2018

description: O défice de zinco no lactente pode ocorrer por aumento das necessidades ou diminuição do aporte. A deficiência sintomática transitória de zinco resulta de uma alteração no transportador de zinco a nível da glândula mamária, conduzindo a níveis reduzidos de zinco no leite materno. Lactentes sob aleitamento materno exclusivo apresentam, nestes casos, um défice de aporte. As manifestações clínicas clássicas de défice de zinco traduzem-se por lesões cutâneas acrais e periorificiais, alopecia e diarreia, sendo indistinguíveis de outras causas de défice de zinco. Verifica-se, contudo, uma remissão das manifestações após o início de diversificação alimentar. O diagnóstico precoce e início de suplementação com zinco adquirem um papel fulcral na prevenção de alterações por défice de zinco a longo prazo.
description: Portuguese Journal of Pediatrics, Vol. 49 No. 2 (2018)
Sonnenfleckenzeichnung Nr. 23349.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 21.05.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Investigation of disulfide bond cleavage, water-cluster cations and PO bonds in phosphates using AB initio electronic structure calculations
Creators: name: Neff, Diane Louise
Publisher: name: University of Utah
Year: 2012
Subjects: Bond
Cation
Disulfide
Mass spectrometry
Rydberg
Water-cluster

description: The chemical bonds that cleave in proteins and peptides during electron capture dissociation (ECD) and electron transfer dissociation (ETD) mass spectrometry are N-C! and disulfide bonds. These types of bonds cleave at a significantly higher rate in ECD and ETD as compared to other types of mass spectrometry, such as collisionally activated dissociation (CAD) mass spectrometry. The mechanism of bond cleavage in ECD and ETD has been a subject of debate. The original mechanism proposed involves a hydrogen atom transfer from the positive site of electron capture to either an SS or N-C! bond. This mechanism came under scrutiny after further investigation. Described herein, is the use of Hartree-Fock and second order Møller-Plesset perturbation calculations to investigate the mechanism of bond cleavage in proteins and peptides during ECD and ETD. The behavior of water-cluster cations of the form [M(H2O)n]2+ were studied in ECD experiments and the outcomes of these experiments were investigated using ab initio electronic structure calculations. These calculations were done in order to understand ECD experiments performed by the Williams group. These experiments were performed with different alkaline earth metals and various numbers of water molecules. Mass-selected doubly charged cations containing alkaline earth metals were subjected to ECD and the mass-to-charge ratios and abundances of the fragmentation ions were determined. For the Ca2+-containing clusters, ECD mass spectrometry was carried out on clusters with 4 to 47 water molecules. It was shown that two different outcomes were possible for these metal-cluster cations, depending on the number of water molecules that were in the cluster. Described herein, is the investigation of the mechanism involved in the two possible reaction pathways. The nature of phosphorus oxygen bonds in phosphates is also described. Hartree-Fock and Møller-Plesset perturbation calculations were employed to examine several systems.
Evolução dos Cuidados de Saúde em Portugal e Seu Impacto na Mortalidade Infantil no Século XX
Creators: name: Oliveira, Juliana
name: Caldas Afonso, Alberto
Publisher: name: Portuguese Journal of Pediatrics
Year: 2018

description: A mortalidade infantil em Portugal diminuiu de uma forma espantosa ao longo do século XX, sendo objetivado uma queda de cerca de 90% da taxa de mortalidade infantil. Este indicador, um clássico em saúde pública, reflete não só as causas biológicas da morte infantil, mas também as causas de ordem social, económica e ambiental. É por isso curioso perceber o que se passou no último século que permitiu esta melhoria espantosa, tendo a evolução na área da medicina e as mudanças políticas e sociais sem dúvida um impacto decisivo.
description: Portuguese Journal of Pediatrics, Vol. 49 No. 2 (2018)
Analytical model of a microscale heat exchanger: ambient interaction and general end-wall boundary conditions
Creators: name: Spann, Bryan T
Publisher: name: University of Utah
Year: 2012
Subjects: Analytical
End-wall boundary conditions
General boundary conditions
Heat exchanger
Microscale

description: Developments in manufacturing have led to progressively smaller and more complex micro-electro-mechanical systems (MEMS), many of which employ heat exchangers to enhance performance. Due to the size constraints on these devices, adiabatic surfaces are difficult to create, and thus, ambient thermal interaction becomes an import factor in heat exchanger  performance. Similarly, end-wall boundary conditions also become a concern at this scale. A unique closed form mathematical solution is presented for single-pass, two-fluid, parallel and counter flow microscale heat exchangers. The model includes the effects of axial wall conduction, ambient thermal interaction at the axial exterior surface, and general end-wall boundary conditions. Heat exchanger effectiveness above unity is found to be possible depending on the magnitude of the ambient thermal interaction and the objective of the heat exchanger. For an objective of heating the cold fluid, end-wall boundary conditions that introduce energy into the system such as isoflux (with heat flux into the system), convection (when the ambient temperature is greater than the end-wall temperature), and isothermal (where the temperature gradients introduce energy into the system) enhance performance. The heat capacity rate ratio is found to have potential for enhancing performance and mitigating the negative effects of ambient thermal interaction. When the ambient temperature is lower than the cold fluid inlet temperature and the heat exchanger objective is to heat the cold fluid, reducing the heat capacity rate ratio results in more energy transfer from the hot fluid to the cold fluid, thus enhancing performance.
Testing and exposing weak graphics processing unit memory models
Creators: name: Sorensen, Tyler Rey
Publisher: name: University of Utah
Year: 2015
Subjects: GPU
Litmus tests
Memory consistency

description: Graphics Processing Units (GPUs) are highly parallel shared memory microprocessors, and as such, they are prone to the same concurrency considerations as their traditional multicore CPU counterparts. In this thesis, we consider shared memory consistency, i.e. what values can be read when issued concurrently with writes on current GPU hardware. While memory consistency has been relatively well studied for CPUs, GPUs present substantially different concurrency systems with an explicit thread and memory hierarchy. Because documentation on GPU memory models is limited, it remains unclear what behaviors are allowed by current GPU implementations. To this end, this work focuses on testing shared memory consistency behavior on NVIDIA GPUs. We present a format for describing GPU memory consistency tests (dubbed GPU litmus tests) which includes the placement of testing threads into the GPU thread hierarchy (e.g. cooperative thread arrays, warps) and memory locations into GPU memory regions (e.g. shared, global). We then present a framework for running GPU litmus tests under system stress designed to trigger weak memory model behaviors, that is, executions that do not correspond to an interleaving of the instructions of the concurrent program. We discuss GPU specific incantations (i.e. heuristics) which we found to be crucial for observing weak memory model executions; these include bank conflicts and custom GPU memory stressing functions. We then report the results of running GPU litmus tests in this framework and show that we observe a controversial relaxed coherence behavior on older NVIDIA chips. We present several examples of published GPU applications which may exhibit unintended behavior due to the lack of fence synchronization; one such example is a spin-lock published in the popular CUDA by Example book. We then test several families of tests and compare our results to a proposed operational GPU memory model and show that the model is unsound (i.e. disallows behaviors that we observe on hardware). Our techniques are implemented in a modified version of a memory model testing tool named litmus.
Exploring the mucoadhesive behavior of sucrose acetate isobutyrate: a novel excipient for oral delivery of biopharmaceuticals
Creators: name: Harloff-Helleberg, Stine
name: Fliervoet, Lies A. L.
name: Fanø, Mathias
name: Schmitt, Mechthild
name: Antopolski, Maxim
name: Urtti, Arto
name: Nielsen, Hanne Mørck
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Oral drug delivery is an attractive noninvasive alternative to injectables. However, oral delivery of biopharmaceuticals is highly challenging due to low stability during transit in the gastrointestinal tract (GIT), resulting in low systemic bioavailability. Thus, novel formulation strategies are essential to overcome this challenge. An interesting approach is increasing retention in the GIT by utilizing mucoadhesive biomaterials as excipients. Here, we explored the potential of the GRAS excipient sucrose acetate isobutyrate (SAIB) to obtain mucoadhesion in vivo. Mucoadhesive properties of a 90% SAIB/10% EtOH (w/w) drug delivery system (DDS) were assessed using a biosimilar mucus model and evaluation of rheological behavior after immersion in biosimilar intestinal fluid. To ease readability of this manuscript, we will refer to this as SAIB DDS. The effect of SAIB DDS on cell viability and epithelial membrane integrity was tested in vitro prior to in vivo studies that were conducted using SPECT/CT imaging in rats. When combining SAIB DDS with biosimilar mucus, increased viscosity was observed due to secondary interactions between biosimilar mucus and sucrose ester predicting considerable mucoadhesion. Mucoadhesion was confirmed in vivo, as radiolabeled insulin entrapped in SAIB DDS, remained in the small intestine for up to 22 h after administration. Moreover, the integrity of the system was investigated using the dynamic gastric model under conditions simulating the chemical composition of stomach fluid and physical shear stress in the antrum under fasted conditions. In conclusion, SAIB is an interesting and safe biomaterial to promote high mucoadhesion in the GIT after oral administration.
Adaptive algorithms for the rejection of sinusoidal disturbances acting on unkown plants
Creators: name: Pigg, Scott Anthony
Publisher: name: University of Utah
Year: 2012
Subjects: Active noise control
Adaptive control
Disturbance rejection
Feedback control
Frequency estimation
System identification

description: The dissertation is concerned with the development and analysis of adaptive algorithms for the rejection of unknown periodic disturbances acting on an unknown  system. The rejection of periodic disturbances is a problem frequently encountered in control engineering, and in active noise and vibration control in particular. A  new adaptive algorithm is presented for situations where the plant is unknown and may be time-varying. Known as the adaptive harmonic steady-state or ADHSS  algorithm, the approach consists in obtaining on-line estimates of the plant frequency response and of the disturbance parameters. The estimates are used to continuously update control parameters and cancel or minimize the effect of the disturbance. The dynamic behavior of the algorithm is analyzed using averaging theory. Averaging theory allows the nonlinear time-varying closed-loop system to be approximated by a nonlinear time-invariant system. Extensions of the algorithm to systems with multiple inputs/outputs and disturbances consisting of multiple frequency components are provided.  After considering the rejection of sinusoidal disturbances of known frequency, the rejection of disturbances of unknown frequency acting on an unknown and time-varying plant is considered. This involves the addition of frequency estimation to the ADHSS algorithm. It is shown that when magnitude phase-locked loop (MPLL) frequency estimation is integrated with the ADHSS algorithm, the two components work together in such a way that the control input does not prevent frequency tracking by the frequency estimator and so that the order of the ADHSS can be reduced. While MPLL frequency estimation can be combined favorably with ADHSS disturbance rejection, stability is limited due to the local convergence properties of the MPLL. Thus, a new frequency estimation algorithm with semiglobal stability properties is introduced. Based on the theory of asynchronous electric machines, the induction motor frequency estimator, or IMFE, is shown to be appropriate for disturbance cancellation and, with modification, is shown to increase stability of the combined ADHSS/MPLL algorithm. Extensive active noise control experiments demonstrate the performance of the algorithms presented in the dissertation when disturbance and plant parameters are changing.
Sonnenfleckenzeichnung Nr. 23527.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 16.12.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Alimentação Entérica Precoce ou Tardia em Recém-Nascidos com Alteração de Fluxos em Ecografia Pré-Natal
Creators: name: Periquito, Isabel
name: Oliveira, Joana
name: Fernandes, Cláudia
name: Ferreira, Marta
name: Barroso, Rosalina
Publisher: name: Portuguese Journal of Pediatrics
Year: 2018

description: Introdução: O principal objetivo deste estudo foi determinar o efeito da introdução de alimentação entérica precoce comparado com introdução tardia, na incidência de morbilidade gastrointestinal e tempo até alimentação entérica total, em recém-nascidos com alteração de fluxos em ecografia pré-natal. Métodos: Análise retrospetiva dos recém-nascidos internados numa unidade de cuidados intensivos neonatais de nível III, em Portugal, entre janeiro de 2004 e dezembro de 2013 com alteração de fluxos em ecografia pré-natal. Foram criados dois grupos baseados no tempo até introdução de primeira alimentação entérica: grupo de alimentação precoce (≤48 horas) e grupo de alimentação tardia (> 48 horas). Os resultados principais foram morbilidade gastrointestinal e mortalidade devido a complicações gastrointestinais. Resultados: Foram incluídos 46 (47%) de recém-nascidos no grupo de alimentação precoce e 52 (53%) no grupo de alimentação tardia. Não houve diferenças significativas na morbilidade gastrointestinal, incluindo enterocolite necrosante, perfuração ou cirurgia gastrointestinal, íleus séptico ou intolerância alimentar. A alimentação precoce resultou numa diminuição significativa da sepsis tardia (p=0,016; odds ratio 0,276; intervalo de confiança 95% 0,096-0,789). Discussão: A introdução precoce de alimentação entérica poderá não ter efeitos significativos na incidência de morbilidade gastrointestinal em recém-nascidos com alteração de fluxos em ecografia pré-natal. Houve uma redução significativa na sepsis tardia, sem condicionar um aumento de risco de morbilidade gastrointestinal.
description: Portuguese Journal of Pediatrics, Vol. 49 No. 2 (2018)
Visualizing intrinsic isosurface variation due to uncertainty through heat kernel signatures
Creators: name: Saquib, Nazmus
Publisher: name: University of Utah
Year: 2014
Subjects: Computational geometry
Computer graphics
Data analysis
Numerical simulation
Shape analysis
Uncertainty visualization

description: It is common to extract isosurfaces from simulation  eld data to visualize and gain understanding of the underlying physical phenomenon being simulated. As the input parameters of the simulation change, the resulting isosurface varies, and there has been increased interest in quantifying and visualization of these variations as part of the larger interest in uncertainty quantification. In this thesis, we propose an analysis and visualization pipeline for examining the intrinsic variation in  isosurfaces caused by simulation parameter perturbation. Drawing inspiration from the shape modeling community, we incorporate the use of heat-kernel signatures (HKS) with a simple  nite-difference approach for quantifying the degree to which a region (or even a point) on an isosurface has undergone intrinsic change. Coupled with a clustering technique and the use of color maps, our pipeline allows the user to select the level of fidelity with which they wish to evaluate and visualize the amount of intrinsic change. The pipeline is described with a simple example to walk the reader through the different steps, and experimental validation of parameter choices in the pipeline is provided to justify our design. Then we present canonical and simulation examples to demonstrate the pipeline's use in different applications.
Sonnenfleckenzeichnung Nr. 23410.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 24.07.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Numerical modeling of high-intensity focused ultrasound-mediated intraperitoneal delivery of thermosensitive liposomal doxorubicin for cancer chemotherapy
Creators: name: Rezaeian, Mohsen
name: Sedaghatkish, Amir
name: Soltani, M.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Although intraperitoneal chemotherapy (IPC) has been suggested as a promising method for the management of peritoneal dissemination (PD) of ovarian or colorectal cancers, the actual clinical use of this method has been restricted due to such problems as poor drug penetration into the tumor and high side effects. It is, therefore, necessary to develop new strategies to improve the efficacy of this approach. In the present work, a new strategy is proposed based on intraperitoneal (IP) injection of thermosensitive liposomal doxorubicin (TSL-Dox) with triggered release by mild hyperthermia induced by high intensity focused ultrasound (HIFU). A computational model is developed to evaluate the proposed drug delivery system. Results show an order of magnitude increase in drug penetration depth into the tumor compared to the conventional IP delivery. Furthermore, the effects of thermal conditions applied to the tumor, TSL size, tumor vessel permeability, and tumor size are investigated. Results indicate an improved efficiency of the drug delivery by expanding the heated region, yet, it increases the risk of unintentional TSL drug load release in the peritoneal cavity. Results also indicate that smaller TSLs have better treatment outcome. However, there is a significant reduction in treatment efficacy for TSLs with sizes smaller than the vessel wall pore size. Thus, tuning the size of TSL should be based on the tumor microvascular permeability. The simulation results suggest that the TSL-Dox delivery system in smaller tumors is far advantageous than larger ones. Results of our model can be used as guidelines for future preclinical studies.