cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of Inversion polymorphism in a complete human genome assembly
Creators: name: Porubsky, David
name: Harvey, William T.
name: Rozanski, Allison N.
name: Ebler, Jana
name: Höps, Wolfram
name: Ashraf, Hufsah
name: Hasenfeld, Patrick
name: Paten, Benedict
name: Sanders, Ashley D.
name: Marschall, Tobias
name: Korbel, Jan O.
name: Eichler, Evan E.
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Sociology
subject: FOS: Sociology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Hematology

description: Additional file 1: Figure S1. T2T-CHM13 inversion callset summary and comparison to GRCh38 (n = 373). Figure S2. Differences between GRCh38 and T2T-CHM13 callsets. Figure S3. Inversion callset summary with respect to T2T-CHM13 reference. Figure S4. Nonsyntenic and likely novel sites in T2T-CHM13 inversion calls. Figure S5. Enrichment of inversions in pericentromeric regions. Figure S6. Sequence composition of inversions from pericentromeric regions. Figure S7. Novel pericentromeric inversion on chromosome 1. Figure S8. Complete assemblies of chromosome 1 centromeric region. Figure S9. Relative position of alpha satellite array and novel pericentromeric inversion on chromosome 1. Figure S10. Inversion phasing at pericentromeric region of chromosome 7. Figure S11. Evaluation of putative misorients in GRCh38 with respect to T2T-CHM13. Figure S12. Evaluation of inversion differences between GRCh38 and T2T-CHM13 references. Figure S13. Examples of minor and misoriented alleles at chromosome 16. Figure S14. Structural differences at Xq28 between GRCh38 and T2T-CHM13. Figure S15. Diverse structural haplotypes at the Xq28 region. Figure S16. Structural differences at 16p12.2 between GRCh38 and T2T-CHM13. Figure S17. Topological differences at 16p12.2 between GRCh38 and T2T-CHM13. Figure S18. Rare inversions at disease relevant loci. Figure S19. Diverse structural haplotypes at 15q25.2 region. Figure S20. Assembled inversion breakpoints at 15q25.2 and inversion breakpoint mapping. Figure S21. Example of long-lasting misorientation errors in previous human genome references. Supplementary Notes. Consortia.
Inhibition of joint damage and improved clinical outcomes with rituximab plus methotrexate in early active rheumatoid arthritis: the IMAGE trial
Creators: name: Tak, P. P.
name: Rigby, W. F.
name: Rubbert-Roth, A.
name: Fleck, Martin
Publisher: name: Universität Regensburg
Year: 2011
Subjects: subject: 610 Medizin

description: Objectives: Rituximab is an effective treatment in patients with established rheumatoid arthritis (RA). The objective of the IMAGE study was to determine the efficacy of rituximab in the prevention of joint damage and its safety in combination with methotrexate (MTX) in patients initiating treatment with MTX. Methods: In this double-blind randomised controlled phase III study, 755 MTX-naïve patients with active RA were randomly assigned to MTX alone, rituximab 2×500 mg + MTX or rituximab 2×1000 mg + MTX. The primary end point at week 52 was the change in joint damage measured using a Genant-modified Sharp score. Results: 249, 249 and 250 patients were randomly assigned to MTX alone, rituximab 2×500 mg + MTX or rituximab 2×1000 mg + MTX, respectively. At week 52, treatment with rituximab 2×1000 mg + MTX compared with MTX alone was associated with a reduction in progression of joint damage (mean change in total modified Sharp score 0.359 vs 1.079; p=0.0004) and an improvement in clinical outcomes (ACR50 65% vs 42%; p<0.0001); rituximab 2×500 mg + MTX improved clinical outcomes (ACR50 59% vs 42%; p<0.0001) compared with MTX alone but did not significantly reduce the progression of joint damage. Safety outcomes were similar between treatment groups. Conclusions: Treatment with rituximab 2×1000 mg in combination with MTX is an effective therapy for the treatment of patients with MTX-naïve RA.
Grand canonical ensembles in general relativity
Creators: name: Klein, David
name: Yang, Wei-Shih
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mathematical Physics (math-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences
subject: 82B21, 83C15, 83F05

description: We develop a formalism for general relativistic, grand canonical ensembles in space-times with timelike Killing fields. Using that formalism we derive ideal gas laws, and show how they depend on the geometry of the particular space-times. A systematic method for calculating Newtonian limits is given for a class of these space-times, which is illustrated for Kerr space-time. In addition, we prove uniqueness of the infinite volume Gibbs measure, and absence of phase transitions for a class of interaction potentials in anti-de Sitter space-time.
description: This manuscript includes minor additions to the original, that appear in the published version. arXiv admin note: substantial text overlap with arXiv:0810.1776
Fibrinogen Mediates Cadmium-induced Macrophage Activation and Serves as a Predictor of Cadmium Exposure in Chronic Obstructive Pulmonary Disease
Creators: name: Li, Fu Jun
Publisher: name: figshare
Year: 2022
Subjects: Cell Biology

description: These are supplemental figures including Fig. S1, Fig. S2, Fig. S3 and Fig. S4. They will be published together with the manuscript.
S156C mutation in tissue inhibitor of metalloproteinases-3 induces increased angiogenesis
Creators: name: Qi, J. H.
name: Dai, G.
name: Luthert, P.
name: Chaurasia, S.
name: Hollyfield, J.
name: Weber, Bernhard H. F.
name: Stöhr, H.
name: Anand-Apte, B.
Publisher: name: Universität Regensburg
Year: 2009
Subjects: subject: 610 Medizin

description: Tissue Inhibitor of metalloproteinases-3 (TIMP-3) is a potent matrix-bound angiogenesis inhibitor. Mutations in TIMP-3 cause Sorsby Fundus Dystrophy, a dominant inherited, early onset macular degenerative disease, with choroidal neovascularization causing a loss of vision in the majority of patients. Here we report that expression of S156C TIMP-3 mutation in endothelial cells results in an abnormal localization of the protein, increased gly co sy la tion, decreased matrix metalloproteinase inhibitory activity, and increased vascular endothelial growth factor (VEGF) binding with a consequent increase in VEGF-de pend ent migration and tube formation. These enhanced signaling events appear to be mediated as a consequence of a post-transcriptionally regulated increase in the expression of membrane-associated VEGFR-2 in endothelial cells of Timp-3156/156 mutant mice as well as in human Sorsby fundus dystrophy eyes. Understanding the mechanism(s) by which mutant TIMP-3 can induce abnormal neovascularization provides important insight into the pathophysiology of a number of diseases with increased angiogenesis.
Non-Markovian Quantum Trajectories of Many-Body Quantum Open Systems
Creators: name: Jing, Jun
name: Zhao, Xinyu
name: You, J. Q.
name: Strunz, W. T.
name: Yu, Ting
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: Chemical Physics (physics.chem-ph)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: A long-standing open problem in non-Markovian quantum state diffusion (QSD) approach to open quantum systems is to establish the non-Markovian QSD equations for multiple qubit systems. In this paper, we settle this important question by explicitly constructing a set of exact time-local QSD equations for $N$-qubit systems. Our exact time-local (convolutionless) QSD equations have paved the way towards simulating quantum dynamics of many-body open systems interacting with a common bosonic environment. The applicability of this multiple-qubit stochastic equation is exemplified by numerically solving several quantum open many-body systems concerning quantum coherence dynamics and dynamical control.
description: 8 pages, 2 figures. manuscript revised and reference updated
Triplet pair correlations in {\it s-}wave superfluids as a signature of the FFLO state
Creators: name: Zapata, I.
name: Sols, F.
name: Demler, E.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We show that triplet pairing correlations are generated in purely s-waves superfluids whenever population imbalance enforces anisotropic Fulde-Ferrell (FF) or inhomogeneous Larkin-Ovchinikov (LO) states. The same set of quasiparticle states contributes to the triplet component and to the polarization, thus spatially correlating them. In the LO case, this set forms a narrow band of Andreev states centered on the nodes of the s-wave order parameter. This picture naturally provides a unifying explanation of previous findings that attractive p-wave interaction stabilizes FFLO states. We also study a similar triplet mixing which occurs when a balanced two-component system displays FFLO type oscillations due to a spin-dependent optical lattice. We discuss how this triplet component can be measured in systems of ultra-cold atoms using a rapid ramp across a p-wave Feshbach resonance. This should provide a smoking gun signature of FFLO states.
description: 4 pages, 3 figures
Additional file 3 of Inversion polymorphism in a complete human genome assembly
Creators: name: Porubsky, David
name: Harvey, William T.
name: Rozanski, Allison N.
name: Ebler, Jana
name: Höps, Wolfram
name: Ashraf, Hufsah
name: Hasenfeld, Patrick
name: Paten, Benedict
name: Sanders, Ashley D.
name: Marschall, Tobias
name: Korbel, Jan O.
name: Eichler, Evan E.
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Sociology
subject: FOS: Sociology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Hematology

description: Additional file 3. Review history.
The Retinome - defining a reference transcriptome of the adult mammalian retina/retinal pigment epithelium
Creators: name: Schulz, H.
name: Götz, T.
name: Kaschkötö, J.
name: Weber, Bernhard H. F.
Publisher: name: Universität Regensburg
Year: 2004
Subjects: subject: 610 Medizin

description: Background The mammalian retina is a valuable model system to study neuronal biology in health and disease. To obtain insight into intrinsic processes of the retina, great efforts are directed towards the identification and characterization of transcripts with functional relevance to this tissue. Results With the goal to assemble a first genome-wide reference transcriptome of the adult mammalian retina, referred to as the retinome, we have extracted 13,037 non-redundant annotated genes from nearly 500,000 published datasets on redundant retina/retinal pigment epithelium (RPE) transcripts. The data were generated from 27 independent studies employing a wide range of molecular and biocomputational approaches. Comparison to known retina-/RPE-specific pathways and established retinal gene networks suggest that the reference retinome may represent up to 90% of the retinal transcripts. We show that the distribution of retinal genes along the chromosomes is not random but exhibits a higher order organization closely following the previously observed clustering of genes with increased expression. Conclusion The genome wide retinome map offers a rational basis for selecting suggestive candidate genes for hereditary as well as complex retinal diseases facilitating elaborate studies into normal and pathological pathways. To make this unique resource freely available we have built a database providing a query interface to the reference retinome [1].
Asymptotic behavior of the Verblunsky coefficients for the OPUC with a varying weight
Creators: name: Poplavskyi, Mihail
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: 15B52, 33C47

description: We present an asymptotic analysis of the Verblunsky coefficients for the polynomials orthogonal on the unit circle with the varying weight $e^{-nV(\cos x)}$, assuming that the potential $V$ has four bounded derivatives on $[-1,1]$ and the equilibrium measure has a one interval support. We obtain the asymptotics as a solution of the system of "string" equations.
description: 28 pages
Generalized Geologic Map for Land-Use Planning: Harlan County, Kentucky
Creators: name: Carey, Daniel I.
name: Webb, Steven E.
name: Davidson, Bart
Publisher: name: Kentucky Geological Survey, University of Kentucky
Year: 2007

description: Abstract:
This map is not intended to be used for selecting individual sites. Its purpose is to inform land-use planners, government officials, and the public in a general way about geologic bedrock conditions that affect the selection of sites for various purposes. The properties of thick soils may supercede those of the underlying bedrock and should be considered on a site-to-site basis. At any site, it is important to understand the characteristics of both the soils and the underlying rock.
Meal choice modeling in a café : the roles of relationship, awareness, and familiarity
Creators: name: Christie, Chelsea Desirée
Publisher: name: University of British Columbia
Year: 2017

description: It is well established that the presence of other people affects how much people eat and the types of food they choose. Past research on food choice modeling has focused on snack foods and has primarily been conducted in controlled laboratory situations. The current research examines modeling of meal choice in a real-life context across two studies. Study 1 (N = 231 café patrons) tested whether meal choice modeling occurs, whether people are aware of being influenced, and whether knowing the model affects whether modeling occurs. The lunch orders of café patrons were surreptitiously tracked and participants were recruited after they paid for their lunch. Participants were asked whether they were influenced by the prior order, and what their relationship was to the person ahead of them in line. As hypothesized, participants modeled the lunch choice of the person ordering ahead of them in line above rates expected by chance. Contrary to predictions about the role of relationship, participants did not model at different rates following a stranger compared to a non-stranger. Hypotheses about modeling awareness were supported with a significant modeling effect observed even among participants who reported that their order was not influenced by the prior order. Study 2 (N = 69 students) tested familiarity to the café or social environment as a moderator. To increase variability in familiarity with the café, participants were students brought into the café for the study. Study 2 yielded inconclusive findings, possibly due to low statistical power. This research provided evidence of meal choice modeling occurring in real-life eating situations and outside of conscious awareness - demonstrating a powerful social influence on health behaviours.
Additional file 1 of COVID-19 and alternative assessments in higher education: implications for academic integrity among nursing and social science students
Creators: name: Adama, Esther Abena
name: Graf, Amanda
name: Adusei-Asante, Kwadwo
name: Afrifa-Yamoah, Ebenezer
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Additional file 1. Survey for academic integrity.
Bernstein von Mises Theorems for Gaussian Regression with increasing number of regressors
Creators: name: Bontemps, Dominique
Publisher: name: arXiv
Year: 2010
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics

description: This paper brings a contribution to the Bayesian theory of nonparametric and semiparametric estimation. We are interested in the asymptotic normality of the posterior distribution in Gaussian linear regression models when the number of regressors increases with the sample size. Two kinds of Bernstein-von Mises Theorems are obtained in this framework: nonparametric theorems for the parameter itself, and semiparametric theorems for functionals of the parameter. We apply them to the Gaussian sequence model and to the regression of functions in Sobolev and $C^α$ classes, in which we get the minimax convergence rates. Adaptivity is reached for the Bayesian estimators of functionals in our applications.
Membrane-associated guanylate kinase proteins MPP4 and MPP5 associate with Veli3 at distinct intercellular junctions of the neurosensory retina
Creators: name: Stöhr, H.
name: Molday, L. L.
name: Molday, R. S.
name: Weber, Bernhard H. F.
name: Biedermann, B.
name: Reichenbach, A.
name: Krämer, F.
Publisher: name: Universität Regensburg
Year: 2005
Subjects: subject: 610 Medizin

description: MPP4 and MPP5 are closely related members of the p55-subfamily of membrane-associated guanylate kinases (MAGUKs) known to mediate the assembly of protein complexes at the plasma membrane of cell–cell junctions. Both MPP4 and MPP5 have been implicated in retinal function; however, their specific roles in the cellular mechanisms underlying vision are largely unknown. Here, we generated specific poly- and monoclonal antibodies against the two proteins and show that MPP4 and MPP5 are localized at distinct sites of cell–cell contact in the mouse retina. While MPP4 is a component of the synaptic terminals of photoreceptors, MPP5 exclusively localizes to apical membrane domains of the outer limiting membrane (OLM) junctions. The vertebrate homologs of Caenorhabditis elegans lin-7, Veli1, -2, and -3, have previously been identified as putative binding partners of MPP5. In this study, we show that MPP4 directly interacts with the Veli proteins via L27 heterodimerization in vitro. In addition, two of the three Veli isoforms, Veli1 and -3, are demonstrated to be expressed in the mouse retina. Immunofluorescence microscopy reveals extensive colocalization of Veli3 with both MPP4 and MPP5. This association of Veli3 with either MPP4 or MPP5 suggests that the MAGUKs recruit Veli3 and its binding partners to different cellular regions of the retina where they may participate in the organization of specialized intercellular junctions.
Mass Varying Neutrinos in Supernovae
Creators: name: Rossi-Torres, F.
name: Guzzo, M. M.
name: de Holanda, P. C.
name: Peres, O. L. G.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the consequences on the neutrino oscillation parameter space, mixing angle ($\tan^2θ$) and vacuum mass difference ($Δm^2_0$), when mass varying neutrino (MaVaN) models are assumed in a supernova environment. We consider electronic to sterile channels $ν_e \rightarrow ν_s$ and $\barν_e \rightarrow \barν_s$ in two-flavor scenario. In a given model of MaVaN mechanism, we induce a position-dependent effective mass difference, $Δ\tilde m^2(r)$, where $r$ is the distance from the supernova core, that changes the neutrino and anti-neutrino flavour conversion probabilities. We study the constraints on the mixing angle and vacuum mass difference coming from r-process and the SN1987A data. Our result is the appearance of a new exclusion region for very small mixing angles, $\tan^2θ=10^{-6}-10^{-2}$, and small vacuum mass difference, $Δm^2_0=~1-20$ eV$^2$, due the MaVaN mechanism.
description: 8 pages, 5 figures
A Preventative Strategy for Autosomal Dominant Polycystic Kidney Disease: Economic and Policy Aspects
Creators: name: Esteban-de-la-Rosa, Rafael-José
name: Navarro-Espigares, José-Luis
name: Bravo-Soto, Juan-Antonio
Publisher: name: Zenodo
Year: 2018

description: Background:
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the hereditary kidney disease that most frequently causes renal failure. Dialysis and transplantation are the therapeutic alternatives currently used. These renal replacement therapies (RRT) entail high health expenditures. There is still no curative treatment for ADPKD.
The objective of this work is to analyse the cost-effectiveness of a preventative strategy aimed at stopping ADPKD transmission based on assisted human reproduction plus preimplantation genetic testing (IVF ICSI + PGT).
Methods:
A comparative analysis of the costs of the IVF ICSI + PGT alternative versus the RRT cost was carried out. The RRT cost was obtained from the specialised literature. The cost of the preventative strategy was calculated by adding the costs of an assisted reproduction procedure in a public hospital and the market price of the PGT in Spain. The average cost of a standard patient during the natural course of the disease has been calculated with patients' records from the registry of Granada (Spain).
Results:
The average costs of transplantation (47,136 and 6,477 euros/year, first year and successive years respectively), haemodialysis (44,778 euros/year), and peritoneal dialysis (34,554 euros/year) are notably higher than costs of preventing the transmission of the disease (5,520-6,020 euros). An incremental cost-effectiveness ratio in favour of the preventative strategy was obtained in a scenario with three single embryo transfers.
Conclusions:
From the perspective of the cost-effectiveness analysis, the preventative strategy proved to be a superior alternative to the renal replacement therapies currently applied. Thus, it would be advisable to promote the strategy of preventing transmission of the disease through assisted human reproduction and genetic testing. Despite the positive contribution of this strategy to the economic sustainability of the public health system, a decided health policy action in its favour is still needed.
Key messages:
The preventative strategy for ADPKD demonstrated advantages in terms of cost-effectiveness plus benefits as regards quality of life.
Public health action in favour of the preventative strategy for ADPKD lacks still decided support among stakeholders.
Tensor networks for dynamic spacetimes
Creators: name: May, Alex
Publisher: name: University of British Columbia
Year: 2017

description: Tensor networks give simple representations of complex quantum states. They have proven useful in the study of condensed matter systems and conformal fields, and recently have provided toy models of AdS/CFT. Underlying the tensor network - AdS/CFT connection is the association of a graph geometry with the tensor network. This geometry is most easily understood as containing only spatial directions. In the context of the AdS/CFT correspondence this limits tensor network toy models to describing static spacetimes. Here we look to extend tensor network models of AdS/CFT by capturing the geometry of a dynamic spacetime in a network description. We review the role of tensor networks in our understanding of AdS/CFT to motivate this extension, before proposing a network picture that captures key features of AdS/CFT.
CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD
Creators: name: Scholl, H. P.
name: Fleckenstein, M.
name: Fritsche, L. G.
name: Schmitz-Valckenberg, S.
name: Göbel, A.
name: Adrion, C.
name: Herold, C.
name: Keilhauer, C. N.
name: Mackensen, F.
name: Mössner, A.
name: Pauleikhoff, D.
name: Weinberger, A. W.
name: Mansmann, U.
name: Holz, F. G.
name: Becker, T.
name: Weber, Bernhard H. F.
Publisher: name: Universität Regensburg
Year: 2009
Subjects: subject: 610 Medizin

description: Background Age-related macular degeneration (AMD) is a prevalent cause of blindness in Western societies. Variants in the genes encoding complement factor H (CFH), complement component 3 (C3) and age-related maculopathy susceptibility 2 (ARMS2) have repeatedly been shown to confer significant risks for AMD; however, their role in disease progression and thus their potential relevance for interventional therapeutic approaches remains unknown. Methodology/Principal Findings Here, we analyzed association between variants in CFH, C3 and ARMS2 and disease progression of geographic atrophy (GA) due to AMD. A quantitative phenotype of disease progression was computed based on longitudinal observations by fundus autofluorescence imaging. In a subset of 99 cases with pure bilateral GA, variants in CFH (Y402H), C3 (R102G), and ARMS2 (A69S) are associated with disease (P = 1.6×10−9, 3.2×10−3, and P = 2.6×10−12, respectively) when compared to 612 unrelated healthy control individuals. In cases, median progression rate of GA over a mean follow-up period of 3.0 years was 1.61 mm2/year with high concordance between fellow eyes. No association between the progression rate and any of the genetic risk variants at the three loci was observed (P>0.13). Conclusions/Significance This study confirms that variants at CFH, C3, and ARMS2 confer significant risks for GA due to AMD. In contrast, our data indicate no association of these variants with disease progression which may have important implications for future treatment strategies. Other, as yet unknown susceptibilities may influence disease progression.
A Mobile ECG System for the Evaluation of Cardiovascular Risk
Creators: name: Villamil, C. A.
name: Landinez, S. F.
name: López, D. M.
name: Blobel, Bernd
Publisher: name: Universität Regensburg
Year: 2016
Subjects: subject: Cardiovascular risk, cardiovascular diseases, ECG, Mobile Health
subject: 610 Medizin

description: Problem: Cardiovascular diseases (CVD) are the number one cause of death globally. The World Health Organization estimated that 80% of the deaths caused by CVD take place in low and middle-income countries (LMIC). Objective: This paper describes the development of a mobile Electrocardiogram (ECG) system designed to support the evaluation of cardiovascular risk. Methods: The system was developed using low-cost technology, implemented under the open-source platform SANA and adding an ECG signal to the process of cardiovascular risk evaluation. Results: Main functionalities of the system include a visualization and analysis of the ECG signal in the Android mobile device, calculation of four cardiovascular risk scales, standard ECG transmission using the European Data Format (EDF), and integration into an Electronic Health Record system. Ten experts recommended 28 different application scenarios for the system, and evaluated its performance (100%) and relevance of the functionalities (89%). Conclusions: The paper demonstrates the feasibility to develop a low-cost, open source, mobile ECG System able to support the evaluation of cardiovascular risk and potentially useful for other health promotion and prevention programs and scenarios, especially in LMIC
Comparison of Jet Quenching Formalisms for a Quark-Gluon Plasma "Brick"
Creators: name: Armesto, Nestor
name: Cole, Brian
name: Gale, Charles
name: Horowitz, William A.
name: Jacobs, Peter
name: Jeon, Sangyong
name: van Leeuwen, Marco
name: Majumder, Abhijit
name: Muller, Berndt
name: Qin, Guang-You
name: Salgado, Carlos A.
name: Schenke, Bjorn
name: Verweij, Marta
name: Wang, Xin-Nian
name: Wiedemann, Urs Achim
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We review the currently available formalisms for radiative energy loss of a high-momentum parton in a dense strongly interacting medium. The underlying theoretical framework of the four commonly used formalisms is discussed and the differences and commonalities between the formalisms are highlighted. A quantitative comparison of the single gluon emission spectra as well as the energy loss distributions is given for a model system consisting of a uniform medium with a fixed length of L=2 fm and L=5 fm (the `Brick'). Sizable quantitative differences are found. The largest differences can be attributed to specific approximations that are made in the calculation of the radiation spectrum.
description: 30 pages, 24 figures update version2: added curves with large x to Figure 14, Higher Twist curves to Figs 19, 20, plus some changes in the text (introduction/summary, discussion of Fig 14 and HT section)
lp-Recovery of the Most Significant Subspace among Multiple Subspaces with Outliers
Creators: name: Lerman, Gilad
name: Zhang, Teng
Publisher: name: arXiv
Year: 2010
Subjects: subject: Machine Learning (stat.ML)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Functional Analysis (math.FA)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: We assume data sampled from a mixture of d-dimensional linear subspaces with spherically symmetric distributions within each subspace and an additional outlier component with spherically symmetric distribution within the ambient space (for simplicity we may assume that all distributions are uniform on their corresponding unit spheres). We also assume mixture weights for the different components. We say that one of the underlying subspaces of the model is most significant if its mixture weight is higher than the sum of the mixture weights of all other subspaces. We study the recovery of the most significant subspace by minimizing the lp-averaged distances of data points from d-dimensional subspaces, where p>0. Unlike other lp minimization problems, this minimization is non-convex for all p>0 and thus requires different methods for its analysis. We show that if 01 and there is more than one underlying subspace, then with overwhelming probability the most significant subspace cannot be recovered or nearly recovered. This last result does not require spherically symmetric outliers.
description: This is a revised version of the part of 1002.1994 that deals with single subspace recovery. V3: Improved estimates (in particular for Lemma 3.1 and for estimates relying on it), asymptotic dependence of probabilities and constants on D and d and further clarifications; for simplicity it assumes uniform distributions on spheres. V4: minor revision for the published version
Additional file 1 of Successful prioritisation of inguinal herniotomies in children during the COVID-19 pandemic to minimise emergency presentations
Creators: name: Marei, Mahmoud Marei
name: Hassan, Ahmed Sobhy
name: Kamel, Mohamed
name: Moore, Aiden
name: Aworanti, Olugbenga Michael
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 1.
Three novel ABCC5 splice variants in human retina and their role as regulators of ABCC5 gene expression
Creators: name: Stojic, J.
name: Stöhr, H.
name: Weber, Bernhard H. F.
Publisher: name: Universität Regensburg
Year: 2007
Subjects: subject: 610 Medizin

description: Background The ABCC5 gene encodes an organic anion pump of the ATP-binding cassette (ABC) transporter family, subclass C. The exact physiological function of ABCC5 however is not known. Here, we have isolated three novel ABCC5 splice variants and characterized their role in the regulation of ABCC5 gene expression. Results Two additional exons within intron 5 of the ABCC5 gene were identified; one of the exons exhibits alternative donor splice sites. Differential usage of these exons generates three short ABCC5 transcripts named ABCC5_SV1, ABCC5_SV2 and ABCC5_SV3. The variants share the first five exons with the ABCC5 gene but differ in their 3' sequences. ABCC5 and its novel isoforms are abundantly expressed in the human retina. Splice variant ABCC5_SV1 and ABCC5_SV2 contain premature stop codons. While inhibition of nonsense-mediated mRNA decay selectively stabilized ABCC5_SV1 but not ABCC5_SV2, the amount of full length ABCC5 mRNA was simultaneously reduced. A negative regulatory effect on full length ABCC5 expression was also observed when the ABCC5 isoforms were silenced with siRNA duplexes. Finally, we show that the evolutionarily conserved ABCC5_SV2 transcript is translated into a protein abundantly present in endothelial cells of inner retinal blood vessels and along RPE membranes. Conclusion Our data suggest that alternative splicing of the ABCC5 gene has functional consequences by modulating ABCC5 gene expression. In addition, at least one ABCC5 splice variant is protein-coding and produces a truncated ABCC5 protein isoform with thus far unknown functional properties in the retina.
Secrecy Results for Compound Wiretap Channels
Creators: name: Bjelakovic, Igor
name: Boche, Holger
name: Sommerfeld, Jochen
Publisher: name: arXiv
Year: 2011
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: We derive a lower bound on the secrecy capacity of the compound wiretap channel with channel state information at the transmitter which matches the general upper bound on the secrecy capacity of general compound wiretap channels given by Liang et al. and thus establishing a full coding theorem in this case. We achieve this with a stronger secrecy criterion and the maximum error probability criterion, and with a decoder that is robust against the effect of randomisation in the encoding. This relieves us from the need of decoding the randomisation parameter which is in general not possible within this model. Moreover we prove a lower bound on the secrecy capacity of the compound wiretap channel without channel state information and derive a multi-letter expression for the capacity in this communication scenario.
description: 25 pages, 1 figure. Accepted for publication in the journal "Problems of Information Transmission". Some of the results were presented at the ITW 2011 Paraty [arXiv:1103.0135] and published in the conference paper available at the IEEE Xplore
pig.PBMC.snATAC.CCAN.files.celltype.DEG.bed.files.zip
Creators: name: Yang, Pengxin
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 310504
subject: Epigenetics (incl. genome methylation and epigenomics)
classificationCode: 310509
subject: Genomics
classificationCode: 310202
subject: Biological network analysis
classificationCode: 310204
subject: Genomics and transcriptomics

description: Such cis-co-accessibility networks (CCAN) are generated using Cicero. Each CCAN has the following characteristics: 1) The “hub” peak of a CCAN overlaps with the transcription starting site (TSS) of a gene which was a differentially expressed gene (DEG) in the matching cell type; 2) all remaining peaks were assigned to the same CCAN as the “hub” peak if the peak has a co-accessibility score with the “hub” peak of at least 0.05 and was no more than 250,000 bp 5’ or 3’ to the gene TSS.
Human-Centered Design of an mHealth App for the Prevention of Burnout Sydrome
Creators: name: Narváez, S.
name: Tobar, A. M.
name: López, D. M.
name: Blobel, Bernd
Publisher: name: Universität Regensburg
Year: 2016
Subjects: subject: User-Centered Design, mHealth App, Burnout
subject: 610 Medizin

description: Background: Stress-related disorders have become one of the main health problems in many countries and organizations worldwide. They can generate depression and anxiety, and could derive in work absenteeism and reduction in productivity. Objective: Design, develop, and evaluate an mHealth App for the prevention of Burnout Syndrome following the recommendations of standard User-Centered Design methodologies. Results: 1) A descriptive cross-sectional study was performed on a sample of 59 faculty members and workers at the University of Cauca, Colombia using the Maslach Burnout Inventory as an instrument for measuring Burnout, accompanied by a demographic and technological questionnaire. 2) Three prototypes of the mHealth App were iteratively developed following the recommendations provided by the ISO Usability Maturity Model and the ISO User-Centered Design model. 3) Usability tests of the system were performed based on the ISO 9126 standard. Conclusions: The results obtained are considered positive, particularly those regarding user's satisfaction measured using the System Usability Scale.
Influence of spin fluctuations near the Mott transition: a DMFT study
Creators: name: Florens, Serge
name: Mohan, Priyanka
name: Janani, C.
name: Gupta, T.
name: Narayanan, R.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Dynamics of magnetic moments near the Mott metal-insulator transition is investigated by a combined slave-rotor and Dynamical Mean-Field Theory solution of the Hubbard model with additional fully-frustrated random Heisenberg couplings. In the paramagnetic Mott state, the spinon decomposition allows to generate a Sachdev-Ye spin liquid in place of the collection of independent local moments that typically occurs in the absence of magnetic correlations. Cooling down into the spin-liquid phase, the onset of deviations from pure Curie behavior in the spin susceptibility is found to be correlated to the temperature scale at which the Mott transition lines experience a marked bending. We also demonstrate a weakening of the effective exchange energy upon approaching the Mott boundary from the Heisenberg limit, due to quantum fluctuations associated to zero and doubly occupied sites.
description: 6 pages, 3 figures. V3 was largely expanded
Prolonged recovery of retinal structure/function after gene therapy in an Rs1h-deficient mouse model of X-linked juvenile retinoschisis
Creators: name: Min, S. H.
name: Molday, L. L.
name: Seeliger, M. W.
name: Dinculescu, A.
name: Timmers, A. M.
name: Janssen, A.
name: Tonagel, F.
name: Tanimoto, N.
name: Weber, Bernhard H. F.
name: Molday, R. S.
name: Hauswirth, W. W.
Publisher: name: Universität Regensburg
Year: 2005
Subjects: subject: 610 Medizin

description: X-linked juvenile retinoschisis (RS) is a common cause of juvenile macular degeneration in males. RS is characterized by cystic spoke-wheel-like maculopathy, peripheral schisis, and a negative (b-wave more reduced than a-wave) electroretinogram (ERG). These symptoms are due to mutations in the RS1 gene in Xp22.2 leading to loss of functional protein. No medical treatment is currently available. We show here that in an Rs1h-deficient mouse model of human RS, delivery of the human RS1 cDNA with an AAV vector restored expression of retinoschisin to both photoreceptors and the inner retina essentially identical to that seen in wild-type mice. More importantly, unlike an earlier study with a different AAV vector and promoter, this work shows for the first time that therapeutic gene delivery using a highly specific AAV5–opsin promoter vector leads to progressive and significant improvement in both retinal function (ERG) and morphology, with preservation of photoreceptor cells that, without treatment, progressively degenerate.
Hereditäre Netzhautdystrophien
Creators: name: Kellner, U.
name: Renner, A. B.
name: Herbst, S. M.
name: Kellner, S.
name: Weinitz, S.
name: Weber, Bernhard H. F.
Publisher: name: Universität Regensburg
Year: 2012
Subjects: subject: 610 Medizin

description: Der Begriff „hereditäre Netzhautdystrophien“ fasst eine genetisch und phänotypisch sehr heterogene Gruppe erblicher Netzhauterkrankungen zusammen, deren gemeinsames Charakteristikum eine fortschreitende Verschlechterung der Sehfunktionen ist. Klinisch werden etwa 100 zum Teil extrem seltene Krankheitsbilder unterschieden. Die hohe phänotypische Variabilität und die insbesondere in frühen Krankheitsstadien oft unspezifischen Netzhautveränderungen und subjektiven Symptome erschweren dem Augenarzt die Diagnosestellung. Umgekehrt ist jedoch für den Patienten eine frühzeitige Diagnosestellung von immenser Bedeutung für die weitere Lebensplanung. Diese Fortbildung fokussiert daher vorwiegend auf eine praxisorientierte Strategie zur adäquaten Diagnostik hereditärer Netzhautdystrophien, jedoch nicht auf die detaillierte Differenzialdiagnose der Netzhautdystrophien. Für den Patienten ist die Einbeziehung hereditärer Netzhautdystrophien in die Differenzialdiagnose einer unklaren Sehstörung von großer Relevanz.
The fundamental theorem of asset pricing, the hedging problem and maximal claims in financial markets with short sales prohibitions
Creators: name: Pulido, Sergio
Publisher: name: arXiv
Year: 2010
Subjects: subject: Pricing of Securities (q-fin.PR)
subject: Probability (math.PR)
subject: FOS: Economics and business
subject: FOS: Mathematics

description: This paper consists of two parts. In the first part we prove the fundamental theorem of asset pricing under short sales prohibitions in continuous-time financial models where asset prices are driven by nonnegative, locally bounded semimartingales. A key step in this proof is an extension of a well-known result of Ansel and Stricker. In the second part we study the hedging problem in these models and connect it to a properly defined property of "maximality" of contingent claims.
description: Published in at http://dx.doi.org/10.1214/12-AAP914 the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Additional file 1 of Factors associated with prehospital delay in acute myocardial infarction in Maldives
Creators: name: Hussain, Madheeh Mohamed
name: Baharuddin, Kamarul Aryffin
name: Fauzi, Mohd Hashairi
name: Abu Bakar, Mimi Azliha
name: Ziyan, Ahmed
name: Ahmed, Aminath Zeyba
name: Sunil, Mohamed
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Computational Biology

description: Additional file 1.
title: What radiologists must know about fibrous dysplasia
Creators: name: Sjekavica, Ivica
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Neoplasia
subject: Technical aspects
subject: MR
subject: CT
subject: Conventional radiography
subject: Musculoskeletal system

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Typical morphological findings of fibrous dysplasia (FD) in different radiological and nuclear imaging modalities. Differential diagnosis and correlation with pathohistological findings. Evaluation of the FD’s malignant...
Duality and the topological filtration
Creators: name: Haution, Olivier
Publisher: name: arXiv
Year: 2010
Subjects: subject: Algebraic Geometry (math.AG)
subject: K-Theory and Homology (math.KT)
subject: FOS: Mathematics
subject: 14C25

description: We investigate some relations between the duality and the topological filtration in algebraic K-theory. As a result, we obtain a construction of the first Steenrod square for Chow groups modulo two of varieties over a field of arbitrary characteristic. This improves previously obtained results, in the sense that it is not anymore needed to mod out the image modulo two of torsion integral cycles. Along the way we construct a lifting of the first Steenrod square to algebraic connective K-theory with integral coefficients, and homological Adams operations in this theory. Finally we provide some applications to the Chow groups of quadrics.
description: To appear in Math. Ann. The numbering of the statements has been modified, in order to be compatible with the published version
The Visegrád Group – A Rising Star Post-Brexit? Changing Distribution of Power in the European Council
Creators: name: Göllner, Ralf Thomas
Publisher: name: Universität Regensburg
Year: 2017
Subjects: subject: Visegrád countries; European Council; voting power; coalition building; Brexit
subject: 320 Politik

description: The portmanteau Brexit describes the withdrawal of the United Kingdom (UK) from the European Union (EU) which will cause a shift of power in the European institutions. The departure of one of the largest EU members will affect the voting power of member countries in the European Council significantly. This Council is the central hub of political decision making in the EU, defining the overall political direction and priorities and setting the policy agenda for the entirety of the EU. Using the Banzhaf power index, we have measured the voting power before and after the Brexit and analyzed the increasing power of the members of the Visegrád Group compared to other European states. We have found that there is growth in the voting power of all Visegrád states, with Poland experiencing the biggest increase. However, the extent by which the Visegrád Group will profit from this statistically growing power depends on the coordination of their voting behavior in the future.
On groups whose geodesic growth is polynomial
Creators: name: Bridson, Martin
name: Burillo, Jose
name: Elder, Murray
name: Sunic, Zoran
Publisher: name: arXiv
Year: 2010
Subjects: subject: Group Theory (math.GR)
subject: FOS: Mathematics
subject: 20F65

description: This note records some observations concerning geodesic growth functions. If a nilpotent group is not virtually cyclic then it has exponential geodesic growth with respect to all finite generating sets. On the other hand, if a finitely generated group $G$ has an element whose normal closure is abelian and of finite index, then $G$ has a finite generating set with respect to which the geodesic growth is polynomial (this includes all virtually cyclic groups).
description: 11 pages, 1 figure
Camille's Case Study: Evaluating a research informed initiative
Creators: name: Gleeson, Jo
name: Cutler, Blake
name: Hall, Genevieve
name: Rickinson, Mark
name: Walsh, Lucas
Publisher: name: Monash University
Year: 2023
Subjects: Professional education and training
Teacher education and professional development of educators
Educational administration, management and leadership

description: This practitioner case study focuses on Camille and how she carefully evaluated a research-informed initiative at her school. This case study was developed by the Monash Q Project (2019-2023) and published as part of the resources for the Monash Faculty of Education short course "An introduction to using research to inform educational practice." The course is designed for teachers, school leaders and education system actors who are beginning to use research in their work and are looking to use research evidence to support their practice.