cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Characterization of a behevior in Caenorhabditis elegans ADAR mutants
Creators: name: Kalyanasundaram, Sandhlya
Publisher: name: University of Utah
Year: 2012
Subjects: Adenosine Deaminase
Mutagenesis

description: Adenosine deaminases that act on RNA (ADARs) are RNA editing enzymes that convert adenosine (A) to inosine (I) and are highly expressed in the nervous system. Homozygous deletion of the Drosphila ADAR results in flies with behavioral defects such as paralysis, uncoordination, tremors as well as brain lesions. In C. elegans, adr-1 is expressed widely in the nervous system and deletion of ADARs results in abnormal chemotaxis. In mammals, absence of editing by ADAR2 at the Q/R site of the glutamate receptor leads to early-onset seizures and postnatal lethality. RNA editing of serotonin receptors results in isoforms with reduced constitutive activity. Since these receptors function in learning and memory and have been shown to be involved in movement, we considered the possibility that worms lacking ADARs have defects in these skills. Using an established thermotaxis assay, we show that C. elegans adr-2 mutants, in contrast to wild type animals, are cryophilic and have defects in finding the temperature of cultivation. However, they retain the ability to track isothermally at a given temperature. Preliminary results also indicate defective thermotaxis behavior in adr-1 and RNAi mutants. Our study suggests that ADARs may have a regulatory role in learning and experience-dependent behavior.
Vom Kamm ob. ober Baumgartenalp
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1877

description: Gämsistock, Claridenfirn und Gämsfairenstock
description: [Johann Müller Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
The Influence of Leg Pain on Recovery After Acute Low Back Pain and Subsequent Treatment Choice
Creators: name: Thackeray, Anne
Publisher: name: University of Utah
Year: 2014

description: Low back (LBP) pain is common and represents a significant societal burden due to costs associated with lost work productivity and medical care. LBP presenting with leg pain, or lumbosacral radicular syndrome (LRS), worsens prognosis and increases disability and cost. Recovery from LBP is highly variable. Improving our understanding of recovery after acute LBP provides an opportunity to change the course of symptoms. Recent studies have identified distinct recovery patterns among patients with LBP. These are generally represented by recovery, moderate persisting pain, high persisting pain, or recurrence. In a cohort of workers with incident LBP, we examined the presence of these patterns. Using pain scores from monthly follow-up visits over the course of 1 year, we characterized recovery. A growth mixture model identified four distinct trajectories consistent with previous literature with distributions favoring recovery. The four classes were identified as recovered (60%), moderate persisting pain (28%), high persisting pain (8%) and recurrent pain (4%). The presence of leg pain increased pain intensity, slowed recovery, and increased the likelihood of being in the high persisting pain class. We further characterized these classes by examining the association between baseline covariates and class status using logistic regression. Moderate persisting pain and high persisting pain was more prevalent among Hispanic workers and those reporting more severe prior low back pain. Additionally, high lifting demands and low social iv support from coworkers was associated with moderate persisting pain. Workers with LRS were twice as likely to have high persisting pain even after adjusting for race and low back pain history (adjusted OR 2.7 (1.4, 5.4)). Finally, in a nationally representative cohort from the SPORT population, we examined nonsurgical treatments utilized in managing patients with persisting symptoms of LRS who seek secondary care but do not elect surgical management. The primary nonsurgical interventions used were medication, spinal injections, and physical therapy. Higher baseline disability, the presence of neurologic deficit, and patient preference for physical therapy were all factors associated with receiving physical therapy as an initial management strategy. Patients receiving physical therapy within the first 6 weeks did not demonstrate any significant differences in primary outcomes of pain and disability compared to those who did not receive physical therapy. Recovery from LBP is highly variable but seems to be described by four distinct patterns of pain. Individuals with low back-related leg pain (LRS) have increased odds of a poor recovery. For patients with persistent LRS, there is significant variation and complexity in nonsurgical management decisions without clear benefit in clinical outcomes. There remains a need to identify optimal management strategies and sequencing of treatment for this population.
Vom Kamm ob der oberen Baumgartenalp
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1877

description: Das Scheidstöckli von Ober Baumgarten aus gesehen; verschiedene Partien der gezeichneten Bergflanke beschriftet mit: "Schutt Halde" oder "Gras"
description: [Johann Müller Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Bounds on the volume of an inclusion in a body and cloaking due to anomalous localized resonance
Creators: name: Thaler, Andrew E.
Publisher: name: University of Utah
Year: 2014
Subjects: Anomalous localized resonance
Electrical impedance tomography
Size estimation
Superlens
Volume fraction

description: We study three problems in this dissertation. In the rst problem, we derive bounds on the volume occupied by an inclusion in a body through the use of a single measurement of the complex voltage and current  ux around the boundary of the body. We assume that the conductivities of the inclusion and the body are complex. In the second problem, we derive a formula that gives the exact volume fraction occupied by a linearly elastic inclusion in a linearly elastic body when both the inclusion and the body have the same shear modulus. The formula for the volume of the inclusion is based on an appropriate measurement of the displacement and traction around the boundary of the body, tailored to force the body to behave as if it were embedded in an innite medium. In the third problem, we prove that the power dissipated in a nonsymmetric slab superlens blows up in the limit as the dissipation parameters in the lens and the surrounding medium go to zero when certain charge density distributions are placed within a critical distance of the slab. The critical distance that leads to this blow-up of the power dissipation depends nontrivially on the relative amount of dissipation in the slab and surrounding medium. This behavior of the power dissipation, in combination with the fact that the potential remains bounded far away from the slab as the dissipation parameters go to zero, leads to cloaking by anomalous localized resonance.
Muot oder Kistenstöckli vom Kistenpass
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1876

description: IM
description: Unterhalb des Titels in Bleistift: "Ostseite"
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Targeting allosteric sites of human aromatase: a comprehensive in-silico and in-vitro workflow to find potential plant-based anti-breast cancer therapeutics
Creators: name: Alhadrami, Hani A.
name: Sayed, Ahmed M.
name: Melebari, Sami A.
name: Khogeer, Asem A.
name: Abdulaal, Wesam H.
name: Al-Fageeh, Mohamed B.
name: Algahtani, Mohammad
name: Rateb, Mostafa E.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology

description: Recent findings suggested several allosteric pockets on human aromatase that could be utilised for the development of new modulators able to inhibit this enzyme in a new mechanism. Herein, we applied an integrated in-silico-based approach supported by in-vitro enzyme-based and cell-based validation assays to select the best leads able to target these allosteric binding sites from a small library of plant-derived natural products. Chrysin, apigenin, and resveratrol were found to be the best inhibitors targeting the enzyme’s substrate access channel and were able to produce a competitive inhibition with IC50 values ranged from 1.7 to 15.8 µM. Moreover, they showed a more potent antiproliferative effect against ER+ (MCF-7) than ER- one (MDA-MB-231) cell lines. On the other hand, both pomiferin and berberine were the best hits for the enzyme’s haem-proximal cavity producing a non-competitive inhibition (IC50 15.1 and 21.4 µM, respectively) and showed selective antiproliferative activity towards MCF-7 cell lines.
Alp Robi ober Staffel am Kistenpass 2175 mt
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1876
Subjects: Almhütte

description: [Johann Müller-Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Cyclocephala simillima Dechambre 1999
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala simillima

description: § Cyclocephala simillima Dechambre, 1999
Cyclocephala simillima Dechambre 1999: 17 (Venezuela (EO))
Distribution. Venezuela (EO): Dechambre 1999: 17 (EO); Moore et al. 2018b: 249 (EO).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 182, DOI: 10.5281/zenodo.3678492
Development of a New Method to Optimize Storage Units in Urban Drainage Systems
Creators: name: Liu, Jing
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2022
Subjects: Over-flooding
Storage units
Resiliency
Multi-objective
Real sewerage system

description: Flood severity and frequency have grown over the years as a result of urban development and climate change. Floods in cities cause major challenges such as property and infrastructure damage, transportation congestion, loss of life, environmental threats, and health concerns. To relieve the load on the urban drainage system and prevent flooding, effective measures to strengthen its resilience are required. Traditional design methods, which rely on past performance trends and long lifespans, usually result in infrastructure that is inflexible and unable to adapt to changing situations. Those traditional studies focused on drainage design, such as pipe slope and diameter optimization, coupling design cost limitation. Furthermore, various terminologies for the overall concept of green/grey infrastructure have been proposed in the literature. Some studies have been focused on the optimization of the suitable locations for storage tanks, which would be one of the most efficient approaches. Building storage facilities such as retention or detention basins are a cost-effective and efficient structural option to improve the resilience of urban sewerage system, reducing peak runoff in existing drainage systems in urban areas, especially compared to traditional methodologies such as increasing pipe diameter or slope providing sufficient hydraulic capacity. The basic concept is to create an optimization framework using Non-dominated Sorting Genetic Algorithm II (NSGA II), coupling with hydraulic model SWMM, and use it to change a number of drainage system-related variables such pipe diameter, slope, and storage unit size. The main idea of the optimization framework in thesis is to combine different methods into one framework, which is a challenge in a complex system due to the dilemma between the resilience objective and financial limitation. Literature review would shows that the recent research in terms of sewerage system resilience optimization utilizing different methodologies. Application of the system would shows that optimization model has the capability to improve the resiliency of urban sewerage system. The main objective of the thesis are (i) develop a new framework to optimize volume and location of storage units in urban drainage systems; (ii) develop a two-stage multi-objective optimization framework; (iii) develop the new index to make the optimization process feasible.
Cyclocephala simulatrix Hohne 1923
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala simulatrix

description: Cyclocephala simulatrix Höhne, 1923
Cyclocephala simulatrix Höhne 1923b: 372 (Peru)
Distribution. Suriname: MHCN - NEW COUNTRY RECORD (Suriname, Sipaliwini, Arapahu Resort, (3°27′N, 57°37.5′W). 24/ 26-II-2011. A. J. Hielkema. On HPL in open area in forest.). French Guiana: Brûlé et al. 2011a: 191, 2014: 181; Duranton 2011: 15; Ponchel 2011: 60; Brûlé and Dalens 2012a annex 4: 18; Dupuis 2016b: 109; Moore et al. 2018b: 249; MHCN. Brazil: Dechambre 1979c: 166; Moore et al. 2018b: 249. Venezuela: Ratcliffe 2003: 226. Other: Höhne 1923b: 372 (Peru, Trinidad and Tobago); Arrow 1937b: 16 (Peru, Trinidad and Tobago); Blackwelder 1944: 252 (Peru, Trinidad and Tobago); Endrödi 1966a: 309 (Bolivia, Costa Rica, Paraguay, Peru, Trinidad and Tobago), 1985a: 89, 122 (Bolivia, Costa Rica, Paraguay, Peru, Trinidad and Tobago); Dechambre 1979c: 166 (Bolivia, Costa Rica, Paraguay, Peru, Trinidad and Tobago); Ratcliffe 2003: 226 (Bolivia, Paraguay, Peru, Trinidad and Tobago); Moore et al. 2018b: 249 (Bolivia, Paraguay, Peru, Trinidad and Tobago).
Note. Endrödi (1966a: 309, 1985a: 89, 122) and Dechambre (1979c: 166) record Cyclocephala simulatrix for Costa Rica. According to Ratcliffe (2003: 226), the records of C. simulatrix from Costa Rica are incorrect, as this species does not occur in Costa Rica or Panama. The species is restricted to mainland South America and Trinidad and Tobago.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 182, DOI: 10.5281/zenodo.3678492
Felskopf zwischen Culm Quader und Piz Dartgass bey Robialp am Kistenpass
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1876

description: IM
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Functional analysis of Tbx5 amd Tbx4 genes
Creators: name: Wang, Song
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Mice

description: Members of T-box family of transcription factors play critical roles in multiple aspects of development. Tbx5 and Tbx4 are a cognate gene pair arising from duplication of a common ancestral gene. Despite the high degree of sequence and structure similarity, these two genes show dramatic differences in their expression patterns and mutant phenotypes. To determine the extent of functional similarity and differences between these two closely related genes, the mouse Tbx5 gene was functionally replaced with Tbx4 sequence by gene targeting. Tbx4, when expressed in a Tbx5 specific pattern, partially restores expression of a Tbx5 downstream target ANF in the developing heart, but fails to rescue the posterior heart growth or cardiac looping defects of Tbx5 mutants. In cell culture, Tbx4 cannot cooperate with Nkx2.5 and fully activate ANF or cx40 expression to the same extent as Tbx5 did. Therefore, the functional differences of Tbx5 and Tbx4 in heart development stem from their different capabilities of cooperating with cofactors to regulate expression of downstream targets. Tbx4, when expressed in the forelimb region, replaces Tbx5 to initiate forelimb bud outgrowth and establishes the early AP and DV polarity of the forelimb bud. However, Tbx4 alone fails to support formation of the AER and continued outgrowth of the forelimb bud. Forelimb buds expressing both Tbx5 and Tbx4 exhibit no hindlimb features, suggesting Tbx4 is not sufficient to induce hindlimb features. This dissertation also studied the mechanism of arrested heart development in Tbx5 mutants. Hypoplasia in the posterior heart of Tbx5 mutants is a result of decreased cell proliferation followed by increased apoptosis in that region. Tbx5 regulates Raldh2 expression, and hence RA signaling, in the posterior heart. However, Raldh2 does not mediate all functions of Tbx5 in posterior heart development, other downstream effectors of  Tbx5 are also required for the proper development of the posterior heart. The Nodal/Pitx2 pathway that establishes LR handedness of developing heart is not affected in Tbx5 mutants, suggesting the cardiac looping defect is a secondary defect due to the unbalanced growth of the heart tube..
New indolesulfonamide derivatives targeting the colchicine site of tubulin: synthesis, anti-tumour activity, structure–activity relationships, and molecular modelling
Creators: name: Vicente-Blázquez, Alba
name: González, Myriam
name: Medarde, Manuel
name: Mollinedo, Faustino
name: Peláez, Rafael
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Searching for improved indolesulfonamides with higher polarities, 45 new analogues with modifications on the sulfonamide nitrogen, the methoxyaniline, and/or the indole 3-position were synthesised. They show submicromolar to nanomolar antiproliferative IC50 values against four human tumour cell lines and they are not P-glycoprotein substrates as their potencies against HeLa cells did not improve upon cotreatment with multidrug resistance (MDR) inhibitors. The compounds inhibit tubulin polymerisation in vitro and in cells, thus causing a mitotic arrest followed by apoptosis as shown by cell cycle distribution studies. Molecular modelling studies indicate binding at the colchicine site. Methylated sulfonamides were more potent than those with large and polar substitutions. Amide, formyl, or nitrile groups at the indole 3-position provided drug-like properties for reduced toxicity, with Polar Surface Areas (PSA) above a desirable 75 Å2. Nitriles 15 and 16 are potent polar analogues and represent an interesting class of new antimitotics.
Piz Dartgass gez. ob Rubi Alp Kistenpass bey Plumbials
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1876

description: JM
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Estimation of the acyclovir concentration in the epidermis following transdermal drug delivery and its correlation with its antiviral efficacy
Creators: name: Song, Wei-qi
Publisher: name: University of Utah
Year: 2012
Subjects: Pharmacokinetics
Drug therapy

description: An experimental animal model for the study of the antiviral efficacy of acyclovir (ACV)  in cutaneous HSV-1   infections utilizing controlled drug delivery with transdermal patches in hairless mice was developed previously. In this model, the extent of virus induced lesion development in skin areas underneath and/or adjacent to the areas covered by the dermal patches was used, in order to evaluate the topical and systemic antiviral efficacy of the patches. Both efficacies were expressed as a function of the drug delivery rate of the dermal patches.  In the present study, the drug concentration in the epidermis/ dermis interface for both topical and systemic drug delivery was estimated. In the case of topical delivery, the drug concentration was deduced from the flux equation for ACV transport across Azone pretreated  hairless mouse skin, assuming  a permeability coefficient of the dermis corresponding to its full anatomical thickness.  In the case of systemic delivery, the drug concentration in the water compartment of the epidermis was obtained from pharmacokinetic studies, which provided steady state blood levels of ACV following dermal patch application with hairless mice. For the equal topical and systemic antiviral efficacy values, the topical drug concentration was found to be 40 times higher than the systemic drug concentration. The reason for this difference was sought in the effect of the blood flow on the effective thickness of the dermis as a transport barrier in vivo. Estradiol was used as a probe in these studies. The transdermal permeation of estradiol and its main metabolite, estrone, was studied in vitro and in vivo using estradiol dermal patches. The experimentally obtained fluxes were fitted to a previously developed computational model for simultaneous transport and metabolism of estradiol in skin, and the effect of a reduced effective dermis thickness was tested.  Different assumptions regarding the location of metabolic enzyme in the skin and the diffusivities in the basal and the keratinized epidermal layers were employed in this model, in order to explain the differences in the estrone back flux between the in vitro and the in vivo experiments. It was shown that a 40-fold reduction of the effective dermis thickness due to the blood flow in vivo was consistent with the experimental data.
Discovery of new VEGFR-2 inhibitors based on bis([1, 2, 4]triazolo)[4,3-a:3',4'-c]quinoxaline derivatives as anticancer agents and apoptosis inducers
Creators: name: Alsaif, Nawaf A.
name: Taghour, Mohammed S.
name: Alanazi, Mohammed M.
name: Obaidullah, Ahmad J.
name: Al-Mehizia, Abdulrahman A.
name: Alanazi, Manal M.
name: Aldawas, Saleh
name: Elwan, Alaa
name: Elkady, Hazem
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Herein, a new wave of bis([1, 2, 4]triazolo)[4,3-a:3',4'-c]quinoxaline derivatives have been successfully designed and synthesised. The synthesised derivatives were biologically investigated for their cytotoxic activities against HepG2 and MCF-7. Also, the tested compounds were further examined in vitro for their VEGFR-2 inhibitory activity. The most promising derivative 23j was further investigated for its apoptotic behaviour in HepG2 cell lines using flow cytometric and western-plot analyses. Additional in-silico studies were performed to predict how the synthesised compounds can bind to VEGFR-2 and to determine the drug-likeness profiling of these derivatives. The results revealed that compounds 23a, 23i, 23j, 23l, and 23n displayed the highest antiproliferative activities against the two cell lines with IC50 values ranging from 6.4 to 19.4 µM. Furthermore, compounds 23a, 23d, 23h, 23i, 23j, 23l, 23 m, and 23n showed the highest VEGFR-2 inhibitory activities with IC50 values ranging from 3.7 to 11.8 nM, comparing to sorafenib (IC50 = 3.12 nM). Moreover, compound 23j arrested the HepG2 cell growth at the G2/M phase and induced apoptosis by 40.12% compared to the control cells (7.07%). As well, such compound showed a significant increase in the level of caspase-3 (1.36-fold), caspase-9 (2.80-fold), and BAX (1.65-fold), and exhibited a significant decrease in Bcl-2 level (2.63-fold).
Unmet Need for Health Care in Germany - EU-SILC 2019
Creators: name: Haltaufderheide, Matthias
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Public Health
subject: Medicine and Health Sciences
subject: Health Services Research

description: The preregistration is part of a student project to obtain a Master's Degree in Public Health (M. Sc.) at the Berlin School of Public Health.
Bey der Alp Arbitteta : Einfischthal
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1860

description: Blick ins Val de Zinal mit dem Besso, Glacier de Moming, Zinalrothorn, Glacier de Zinal, Ober Gabelhorn und Dent Blache im Hintergrund; das Val d' Anniviers wurde früher auch Eifischtal oder Einfischtal bezeichnet
description: nach Bühlmann ; [Kopie Johann Müller-Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Cyclocephala stictica Burmeister 1847
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala stictica

description: Cyclocephala stictica Burmeister, 1847
Cyclocephala stictica Burmeister 1847: 66 (Mexico - LECTOTYPE)
= Cyclocephala sexnotata Burmeister 1847: 67 (French Guiana)
Distribution. French Guiana: Burmeister 1847: 67 (as C. sexnotata); Endrödi 1966a: 314; Duranton 2011: 15; Ponchel 2011: 60; Dupuis 2016b: 109; Moore et al. 2018b: 251. “Guianas”: Arrow 1937b: 15 (as C. sexnotata); Blackwelder 1944: 252 (as C. sexnotata). Brazil: Endrödi 1966a: 314; Ratcliffe et al. 2013: 231; Moore et al. 2018b: 251. Venezuela: Endrödi 1966a: 314; Moore et al. 2018b: 251. Other: Burmeister 1847: 66 (Mexico); Arrow 1937b: 16 (Mexico); Blackwelder 1944: 253 (Mexico); Endrödi 1966a: 314 (Bolivia, Colombia, Costa Rica, Ecuador, El Salvador, Guatemala, Mexico - designation LECTOTYPE Cyclocephala stictica, Nicaragua, Panama), 1985a: 48, 120 (Bolivia–Mexico); Lachaume 1992: 13 (Bolivia–Mexico); Ratcliffe et al. 2013: 231 (Brazil/Bolivia–Mexico); Moore et al. 2018b: 251 (Belize, Bolivia, Colombia, Costa Rica, Ecuador, El Salvador, Guatemala, Honduras, Mexico, Nicaragua, Panama, Peru).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 183, DOI: 10.5281/zenodo.3678492
Synthesis, antiproliferative and antitrypanosomal activities, and DNA binding of novel 6-amidino-2-arylbenzothiazoles
Creators: name: Racané, Livio
name: Rep, Valentina
name: Pavelić, Sandra Kraljević
name: Grbčić, Petra
name: Zonjić, Iva
name: Stojković, Marijana Radić
name: Taylor, Martin C.
name: Kelly, John M.
name: Raić-Malić, Silvana
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: A series of 6-amidinobenzothiazoles, linked via phenoxymethylene or directly to the 1,2,3-triazole ring with a p-substituted phenyl or benzyl moiety, were synthesised and evaluated in vitro against four human tumour cell lines and the protozoan parasite Trypanosoma brucei. The influence of the type of amidino substituent and phenoxymethylene linker on antiproliferative and antitrypanosomal activities was observed, showing that the imidazoline moiety had a major impact on both activities. Benzothiazole imidazoline 14a, which was directly connected to N-1-phenyl-1,2,3-triazole, had the most potent growth-inhibitory effect (IC50 = 0.25 µM) on colorectal adenocarcinoma (SW620), while benzothiazole imidazoline 11b, containing a phenoxymethylene linker, exhibited the best antitrypanosomal potency (IC90 = 0.12 µM). DNA binding assays showed a non-covalent interaction of 6-amidinobenzothiazole ligands, indicating both minor groove binding and intercalation modes of DNA interaction. Our findings encourage further development of novel structurally related 6-amidino-2-arylbenzothiazoles to obtain more selective anticancer and anti-HAT agents.
In sickness or in health: couples' health status and retirement prepartation
Creators: name: Taylor, Lorayne B.
Publisher: name: University of Utah
Year: 2013
Subjects: Couple health
Financial planning
Retirement
Retirement preparation

description: This study examines retirement preparation activities among a sample of University of Utah employees as predicted by past diagnoses for one of six major diseases among respondents and their spouses. This research combines data from the University of Utah Retirement Planning Survey (UURPS) with medical records from the Utah Population Database (UPDB). As a measure of retirement preparation, this study examines self-reported retirement planning behaviors and total wealth accumulation in the UURPS. The UPDB provides data on the respondents' and their spouses' health histories. The availability of objective health measures from the UPDB provides an advantage over self-reported health status measures by using official diagnoses. The study examines health-related differences in retirement preparation in four domains: (1) meeting with an advisor, (2) opening a supplemental retirement account, (3) figuring retirement financial needs, and (4) total wealth accumulation. Health history of the respondent and spouse are measured in terms of hospitalizations since 1996 for ischemic heart disease, cerebrovascular disease (stroke), chronic obstructive pulmonary disease (COPD), diabetes, and cerebral degenerations. A health history of cancer is measured both in terms of hospitalizations and diagnoses from the cancer registry dated back to 1966. The results of multivariate regressions indicate that those who have been diagnosed or whose spouse has been diagnosed with cancer are more likely to see an 5 advisor and open a supplemental retirement account. For females whose spouse had been diagnosed with cancer, there was a decrease in total retirement wealth of $67,600 compared to couples in which a cancer diagnosis had not occurred. The association between cancer diagnosis and retirement behaviors and savings could be greater in the general population due to the generous nature of the employee benefits available at the University of Utah, including both excellent health insurance with low out-of-pocket maximums and generous employer retirement participation. Implications for financial planners are discussed along with suggestions for further research based on the results of this exploratory study.
Ortstock oder Silberstock : gez. vom Kamm ob Ober Baumgartenalp 1730
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1877

description: IM
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Advanced materials and concepts for energy storage devices
Creators: name: Teng, Shiang Jen
Publisher: name: University of Utah
Year: 2015
Subjects: Lithium ion battery
Solid state electrolyte
Supercapacitor

description: Over the last decade, technological progress and advances in the miniaturization of electronic devices have increased demands for light-weight, high-efficiency, and carbon-free energy storage devices. These energy storage devices are expected to play important roles in automobiles, the military, power plants, and consumer electronics. Two main types of electrical energy storage systems studied in this research are Li ion batteries and supercapacitors. Several promising solid state electrolytes and supercapacitor electrode materials are investigated in this research. The first section of this dissertation is focused on the novel results on pulsed laser annealing of Li7La3Zr2O12 (LLZO). LLZO powders with a tetragonal structure were prepared by a sol-gel technique, then a pulsed laser annealing process was employed to convert the tetragonal powders to cubic LLZO without any loss of lithium. The second section of the dissertation reports on how Li5La3Nb2O12 (LLNO) was successfully synthesized via a novel molten salt synthesis (MSS) method at the relatively low temperature of 900°C. The low sintering temperature prevented the loss of lithium that commonly occurs during synthesis using conventional solid state or wet chemical reactions. The second type of energy storage device studied is supercapacitors. Currently, research on supercapacitors is focused on increasing their energy densities and lowering their overall production costs by finding suitable electrode materials. The third section iv of this dissertation details how carbonized woods electrodes were used as supercapacitor electrode materials. A high energy density of 45.6 Wh/kg and a high power density of 2000 W/kg were obtained from the supercapacitor made from carbonized wood electrodes. The high performance of the supercapacitor was discovered to originate from the hierarchical porous structures of the carbonized wood. Finally, the fourth section of this dissertation is on the electrochemical effects of embedding Cu nanoparticles into a carbonized wood supercapacitor. The nano-composites were fabricated using a solution method. The electrochemical measurements indicated that Cu nanoparticles did enhance the energy density of the supercapacitor by a factor of three. Both cyclic voltammetry and cyclic charge-discharge measurements showed that the electrode has typical reversible pseudocapacitive behavior, with two pairs of redox reaction peaks.
Skizze gezeichnet während Regen unter dem Schirm gegen Schopfwand und Camperdun vom Elm im Sernfthal
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1876

description: IM.
description: Format unregelmässig
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Kamm von den Muttenbergen bis Piz da Dartgass : gezeichnet vom Kistenpass
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1876

description: IM
description: Verso: Zeichnung eines Berges in Blesitift und Bezeichnung: "Von Davos Seite Pischa das Schwarzhorn vom Fluelapass Davosseite"
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
title: Memoria 2009
Creators: name: Universidad Especializada de las Américas, UDELAS
Publisher: name: Universidad Especializadas de las Américas
Year: 2019
Subjects: subject: FOS: Educational sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: La Universidad Especializada de las Américas -UDELAS- acatando lo dispuesto en la Constitución Nacional, presenta este informe que identifica las mejoras y apertura de nuevas carreras mediante el enfoque interdisciplinario y de participación ciudadana, que contribuyan al desarrollo, la equidad y calidad de vida de los panameños.
einige Verwitterungsbilder auf dem Kistenpass : in der Höhe von 2550-2590 mt
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1876

description: Drei unterschiedliche Verwitterungserscheinungen des Gesteins beim Kistenpass. Oben: "Bündnerseite": "Tafelartige Verwitterung einzelstehende Blöcke" und "Würfelartige Verwitterung einzelstehnde Blöck". Unten: "Nordwest Seite vom Kamm vom Muttenwändli Glarnerseite" und "Schalenartige Verwitterung Bündnerseite"
description: IM.
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Hair as a matrix for biomarkers of pesticide exposure
Creators: name: Hubbard, Deanna Leigh
Publisher: name: University of Utah
Year: 2012
Subjects: Analysis
Biochemical Markers

description: The majority of Americans not involved in manufacturing or applying pesticides are exposed to pesticides through dietary intake. Exposure to this portion of the population can be only estimated, using average food consumption profiles and food concentrations of pesticides. Long-term biomarkers of exposure do not currently exist. Hair is a matrix that is an alternative to the more traditional matrices of plasma and urine. Hair may provide an extended sampling time (weeks to months) when compared to plasma and urine (hours to days). In this research, pesticides (and metabolites) of three chemical classes were used to evaluate hair as a matrix. The plasma pharmacokinetic profiles and the time courses of incorporation into hair were determined for DDT, atrazine and malathion. Hair concentrations were measured after 5 days of pesticide administration. The melanin affinities of the pesticides were determined in an in vitro binding study. All compounds, except DDA, were detectable in plasma. Malathion, malaoxon and DDA were not detected in hair. The remaining compounds incorporated equally into pigmented and nonpigmented hair. The hair time-course demonstrated higher concentrations of atrazine, desisoatrazine, DDT and DDE at early postdose times (prior to 2 days). These compounds demonstrated weak affinities for melanin (
Transition metal-catalysed A-ring C–H activations and C(sp2)–C(sp2) couplings in the 13α-oestrone series and in vitro evaluation of antiproliferative properties
Creators: name: Traj, Péter
name: Abdolkhaliq, Ali Hazhmat
name: Németh, Anett
name: Dajcs, Sámuel Trisztán
name: Tömösi, Ferenc
name: Lanisnik-Rizner, Tea
name: Zupkó, István
name: Mernyák, Erzsébet
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Hematology

description: Facile syntheses of 3-O-carbamoyl, -sulfamoyl, or -pivaloyl derivatives of 13α-oestrone and its 17-deoxy counterpart have been carried out. Microwave-induced, Ni-catalysed Suzuki–Miyaura couplings of the newly synthesised phenol esters with phenylboronic acid afforded 3-deoxy-3-phenyl-13α-oestrone derivatives. The carbamate and pivalate esters proved to be suitable for regioselective arylations. 2-(4-Substituted) phenyl derivatives were synthesised via Pd-catalysed, microwave-assisted C–H activation reactions. An efficient, one-pot, tandem methodology was elaborated for the introduction of the carbamoyl or pivaloyl group followed by regioselective C-2-arylation and subsequent removal of the directing group. The antiproliferative properties of the novel 13α-oestrone derivatives were evaluated in vitro on five human adherent cancer cell lines of gynaecological origin. 3-Sulfamate derivatives displayed substantial cell growth inhibitory potential against certain cell lines. The newly identified antiproliferative compounds having hormonally inactive core might be promising candidates for the design of more active anticancer agents.
Cyclocephala subsignata Burmeister 1847
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala subsignata

description: Cyclocephala subsignata Burmeister, 1847
Cyclocephala subsignata Burmeister 1847: 52 (French Guiana - LECTOTYPE)
Distribution. Guyana: Bodkin 1919: 215; Endrödi 1966a: 316 (designation NEOTYPE Cyclocephala subsignata), 1985a: 92, 136; Dechambre 1979c: 166; Moore et al. 2018b: 253. Suriname: Endrödi 1966a: 316, 1985a: 92, 136; Dechambre 1979c: 166; Moore et al. 2018b: 253; MHCN; NZCS. French Guiana: Burmeister 1847: 52; Endrödi 1966a: 316, 1985a: 92, 136; Dechambre 1979c: 166, 1991: 124 (designation LECTOTYPE Cyclocephala subsignata); Brûlé et al. 2011a: 191, 2014: 181; Duranton 2011: 15; Ponchel 2011: 60; Dupuis 2016b: 109; Moore et al. 2018b: 253; MHCN; RMNH. “Guianas”: Arrow 1937b: 16; Blackwelder 1944: 253. Brazil: Dechambre 1979c: 166; Moore et al. 2018b: 253.
Note. The neotype of Cyclocephala subsignata designated in Endrödi (1966a: 316) was rendered invalid when type material of Burmeister was recovered and a lectotype was designated in Dechambre (1991: 124).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 183, DOI: 10.5281/zenodo.3678492
Beym Thor am Kistenpass : Tödi - Claridenstock Clariden Gletscher Teufelstöck Gemsfayren
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1876

description: [Johann Müller-Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Changes in patterns of political participation and engagement in Thailand, 2001-2007
Creators: name: Thananithichot, Stithorn
Publisher: name: University of Utah
Year: 2012
Subjects: Political engagement
Political participation
Thailand

description: This dissertation presents political participation and engagement trends in Thailand, seeking to explain how and why the quantity, quality, and equality of political  participation and engagement have changed during the past decade (2001 - 2010). Data for its quantitative analyses are taken from two major sources. The first source is information collected by several government agencies such as the National Statistics Bureau (NSB) and the Office of Election Commission (ECT). The second source is data taken from several national surveys conducted in Thailand during the last decade by the  Asian Barometer (ABS) and the Comparative Study of Electoral Systems (CSES).  Relying on its longitudinal analyses, this dissertation argues that political participation and engagement in Thailand since 2001 has changed-not only in its  quantity (number of participants) but also in its quality and equality. In order to explain changes in patterns of political participation, this dissertation proposes a participatory model that included not only socioeconomic status but also various attitudinal and mobilization factors to be tested in several context;s (years). This dissertation claims that participatory differences among groups of Thai citizens were not solely a consequence of  differences in socioeconomic status backgrounds. Rather, there are various psychological, motivational, and context;ual factors affecting participatory disparities among social groups. Additionally, people participate in politics differently depending on types of political activity and on the political environment.
Vom Muttenwändli am Kistenpass bey sehr starkem Föhnwind und Blendung : Standpunct der Zeichnung etwas über Punct 2546 m der Excursionsrout
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1877

description: Blick zum Muttsee mit dem Muttenwändli auf der linken Seite und dem Ruchi auf der rechten Seite im Hintergrund
description: IM
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Understanding language barriers: nurses' and patients' perspectives
Creators: name: Sanchez-Campos, Monica Cecilia
Publisher: name: University of Utah
Year: 2012
Subjects: Nurse and Patient
Health Facilities
Postnatal Care
Hispanic Americans

description: As the Hispanic community becomes the largest minority in the United States, it is important for health-care providers to explore ways to enhance communication with their Spanish-speaking patients. Research is abundant in this field but scare in on of the most vulnerable populations, postpartum women.  This work focused on describing the thoughts, feelings, and ideas from nurses and patients regarding language barriers in the health-care setting.  Towards this aim, I took two approaches.  First 15 registered nurses' and 11 patients' responses were obtained and analyzed from four focus group discussions in order to answer research questions.  Frustration and fear were among the major themes extracted from analyzing responses and were the common denominators for all groups.  Interestingly, all participants were embarrassed to use their limited foreign language skills.  A series of misunderstanding situations were identified in all participants' groups, as it was a concern for confidentiality issues and the belief that it was not their sole responsibility to learn a foreign language.  Assumptions" was a topic for the nurse groups and "quality of interpreters" was a topic for the patients would like nurses to learn Spanish and nurses would like patients to speak English. Most groups also contemplated the possibility of pocket-size translator as a solution.   Second, the demographic questionnaires revealed that short-term nurse employees are more prepared with Spanish classes than long-term nurse employees.  In addition, most of the nurses did not feel comfortable taking care of Spanish-speaking patients.  For patients, their answers revealed that most of them were in their early 20s, their level of education was below ninth grade, and their family income was below the poverty level.  Patients had been residing in the United States for less than 9 years, and none of them had medical insurance.  Understanding participants' perspectives about language barriers and practicing solutions addressed by the affected parties are vital in order to make modifications accurate and valuable to those involved.  When these improvements are applied to the health-care setting, their implementation achieves significance as misdiagnosis, misinterpretation, dissatisfaction, and negative health outcomes are reduced.
Controlling neural cell behavior at biomaterial interfaces
Creators: name: Biran, Roy
Publisher: name: University of Utah
Year: 2012
Subjects: Astrocytes
Nervous System

description: The goal of the research outline in this work was to characterize the effects of surface chemistry, intermediary proteins, and topography on the behavior of cell derived from the nervous system.  These studies were initiated in order to provide input specifications for the design of improved bioartificial substrates for use in promoting nerve regeneration.  The development of synthetic material based devices for restoring damaged neuronal tracts in an area of expanding scientific effort.  A critical factor in the development of such devices is an understanding of the cell-material interactions and methods to manipulate these interactions in the target host tissue.  To this end, two important cell types of the nervous system were examined:  astrocytes, which represent an important wound healing type in the CNS, and neurons.  In the first study, the attachment and growth of primary astrocytes (Chapter 4) and neurons (Appendix A) were characterized on polymeric materials of varying surface chemistries.  Although differences in attachment and growth were evident initially, over time in culture astrocytes were capable to forming confluent monolayers on all the materials.  On the other hand, little correlation was observed between neuronal behavior and material wettability.  Neurite outgrowth, however, appeared to be highly sensitive to the presence of serum.  In the second, study, a method for immobilizing proteins to surfaces in serum-resistant manner was examined for its effects on neuronal attachment and outgrowth.  Attachment and outgrowth could be controlled in a dose-dependent and serum-resistant manner only on immobilized but no absorbed FN.  The third study investigated the behaviors of PNS and CNS neurons on differing surface topographies.  The effect of groove depth on the alignment and orientation of neurite outgrowth was measured.  Neuronal alignment along the longitudinal axis of the grooves was influenced by groove depth and neuron type.  Neurons also aligned even when an underlying support layer of astrocytes was plated onto the grooved substrate, indicating that physical cues could be transduced through multiple cell layers.  Together these studies demonstrate the importance and potential utility of controlling not only the intermediary protein layer on the material surface, but the potential application of surface topography, possible even through multiple cell layers, to control and direct neuronal behaviors.  In the future, such strategies may be implemented in the design of novel biomaterial-based devices for applications in the nervous system.