cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Planning Optimal From the Firm Value Creation Perspective Levels of Operating Cash Investments
Creators: name: Michalski, Grzegorz
Publisher: name: arXiv
Year: 2013
Subjects: subject: Risk Management (q-fin.RM)
subject: Portfolio Management (q-fin.PM)
subject: FOS: Economics and business

description: The basic financial purpose of corporation is creation of its value. Liquidity management should also contribute to realization of this fundamental aim. Many of the current asset management models that are found in financial management literature assume book profit maximization as the basic financial purpose. These book profit based models could be lacking in what relates to another aim like maximization of enterprise value. The corporate value creation strategy is executed with a focus on risk and uncertainty. Firms hold cash for a variety of reasons. Generally, cash balances held in a firm can be called considered, precautionary, speculative, transactional and intentional. The first are the result of management anxieties. Managers fear the negative part of the risk and hold cash to hedge against it. Second, cash balances are held to use chances that are created by the positive part of the risk equation. Next, cash balances are the result of the operating needs of the firm. In this article, we analyze the relation between these types of cash balances and risk. This article presents the discussion about relations between firm net working investment policy and as result operating cash balances and firm value. This article also contains propositions for marking levels of precautionary cash balances and speculative cash balances. Application of these propositions should help managers to make better decisions to maximize the value of a firm.
When the piper pays - content delivery and consumer outcomes
Creators: name: Howell, Bronwyn
name: Potgieter, Petrus
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2022
Subjects: subject: 80502 Mobile Technologies
subject: FOS: Computer and information sciences
subject: 200102 Communication Technology and Digital Media Studies
subject: FOS: Media and communications
subject: 80110 Simulation and Modelling

description: There is no doubt that streaming content services add great value to the internet ecosystem but how the investment to enable these services and the arising revenue should be split is a persistent dilemma (Stocker & Knieps 2021). The purpose of this paper is to investigate, in a discrete model, the effect on the broadband market when an over-the-top subscription content product is introduced. Does it necessarily increase or decrease profitability of the broadband product when it (a) boosts the utility of broadband but (b) imposes additional costs to deliver the broadband service? The short answer is – it depends. We introduce a model with a small number of consumers to show how the outcomes depend on the structure of the consumer valuations. The different scenarios that we choose to illustrate this, demonstrate that in many cases the broadband and content providers can jointly benefit from coordination on how the content product is priced. This coordination might involve a financial consideration, of course. This is in contrast with the case where the broadband provider attempts to unilaterally reprice its product to reflect the increased cost of delivering the content product – which is not always possible
Comparing Labor Market Participation Rates of Ethnic Populations with Innovative Administrative Data for Migration Studies
Creators: name: Daniela, Hochfellner
name: Frederik, Springer
name: Anja, Wurdack
Publisher: name: London : Routledge
Year: 2013
Subjects: subject: Dewey Decimal Classification::300 | Sozialwissenschaften, Soziologie, Anthropologie

description: The integration of different ethnic groups into the labour market is a crucial issue, as high labor participation rates guarantee the accumulation of human capital and support the continuous integration in societies. In Germany, unfortunately, the availability of detailed data sources on migration is limited. Due to the fact that transnational attributes are classified as sensitive information with high disclosure risks, public use files usually do not contain the relevant information. Thus, researchers often have to apply for restricted data access in order to study migration topics. One of these data files was recently developed within the grant “Biographical Data of Selected Social Insurance Agencies in Germany (BASiD)”. Because it makes it possible to distinguish between Germans, foreigners, naturalized citizens, and ethnic German immigrants, the new dataset offers unique opportunities for analyses in the field of migration. Using this data source, our analysis of employment rates from 1965 to 2007 has shown, among other things, that ethnic Germans have about the same level of employment as Germans, while immigrants lag significantly behind. Our article demonstrates how BASiD enables analyses of difficulties, characteristics, and resources of immigrants in general and transmigrants in particular.
Genechip analysis of human embryonic stem cell differentiation into hemangioblasts: An in silico dissection of mixed phenotype
Creators: name: Hipp, Jason D
name: Atala, Anthony
name: Feng, Qiang
name: Lu, Shi-Jiang
name: Lanza, Robert
name: Hipp, Jennifer A
Publisher: name: BioMed Central Ltd
Year: 2007

description: Abstract Background Microarrays are being used to understand human embryonic stem cell (hESC) differentiation. Most differentiation protocols use a multi-stage approach that induces commitment along a particular lineage. Therefore, each stage represents a more mature and less heterogeneous phenotype. Thus, characterizing the heterogeneous progenitor populations upon differentiation are of increasing importance. Here we describe a novel method of data analysis using a recently developed differentiation protocol involving the formation of functional hemangioblasts from hESCs. Blast cells are multipotent and can differentiate into multiple lineages of hematopoeitic cells (erythroid, granulocyte and macrophage), endothelial and smooth muscle cells. Results Large-scale transcriptional analysis was performed at distinct time points of hESC differentiation (undifferentiated hESCs, embryoid bodies, and blast cells, the last of which generates both hematopoietic and endothelial progenies). Identifying genes enriched in blast cells relative to hESCs revealed a genetic signature indicative of erythroblasts, suggesting that erythroblasts are the predominant cell type in the blast cell population. Because of the heterogeneity of blast cells, numerous comparisons were made to publicly available data sets in silico, some of which blast cells are capable of differentiating into, to assess and characterize the blast cell population. Biologically relevant comparisons masked particular genetic signatures within the heterogeneous population and identified genetic signatures indicating the presence of endothelia, cardiomyocytes, and hematopoietic lineages in the blast cell population. Conclusion The significance of this microarray study is in its ability to assess and identify cellular populations within a heterogeneous population through biologically relevant in silico comparisons of publicly available data sets. In conclusion, multiple in silico comparisons were necessary to characterize tissue-specific genetic signatures within a heterogeneous hemangioblast population.
Existence and stability of a screw dislocation under anti-plane deformation
Creators: name: Hudson, Thomas
name: Ortner, Christoph
Publisher: name: arXiv
Year: 2013
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 74G25, 74G65, 70C20, 49J45, 74M25, 74E15

description: We formulate a variational model for a geometrically necessary screw dislocation in an anti-plane lattice model at zero temperature. Invariance of the energy functional under lattice symmetries renders the problem non-coercive. Nevertheless, by establishing coercivity with respect to the elastic strain and a concentration compactness principle, we prove existence of a global energy minimiser and thus demonstrate that dislocations are globally stable equilibria within our model.
description: 33 Pages, 7 Figures
A global reference for human genetic variation
Creators: name: Li, Yun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The 1000 Genomes Project set out to provide a comprehensive description of common human genetic variation by applying whole-genome sequencing to a diverse set of individuals from multiple populations. Here we report completion of the project, having reconstructed the genomes of 2,504 individuals from 26 populations using a combination of low-coverage whole-genome sequencing, deep exome sequencing, and dense microarray genotyping. We characterized a broad spectrum of genetic variation, in total over 88 million variants (84.7 million single nucleotide polymorphisms (SNPs), 3.6 million short insertions/deletions (indels), and 60,000 structural variants), all phased onto high-quality haplotypes. This resource includes >99% of SNP variants with a frequency of >1% for a variety of ancestries. We describe the distribution of genetic variation across the global sample, and discuss the implications for common disease studies.
Rheological effects in the linear response and spontaneous fluctuations of a sheared granular gas
Creators: name: Brey, J. Javier
name: Maynar, P.
name: de Soria, M. I. Garcia
Publisher: name: arXiv
Year: 2012
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: The decay of a small homogeneous perturbation of the temperature of a dilute granular gas in the steady uniform shear flow state is investigated. Using kinetic theory based on the inelastic Boltzmann equation, a closed equation for the decay of the perturbation is derived. The equation involves the generalized shear viscosity of the gas in the time-dependent shear flow state, and therefore it predicts relevant rheological effects beyond the quasi-elastic limit. A good agreement is found when comparing the theory with molecular dynamics simulation results. Moreover, the Onsager postulate on the regression of fluctuations is fulfilled.
Current cigarette smoking among in-school American youth: results from the 2004 National Youth Tobacco Survey
Creators: name: Muula, Adamson S
name: Rudatsikira, Emmanuel
name: Siziya, Seter
Publisher: name: BioMed Central Ltd
Year: 2009

description: Abstract Background Tobacco use is a leading cause of preventable morbidity and mortality. In the developed nations where the burden from infectious diseases is lower, the burden of disease from tobacco use is especially magnified. Understanding the factors that may be associated with adolescent cigarette smoking may aid in the design of prevention programs. Methods A secondary analysis of the 2004 United States National Youth Tobacco Survey was carried out to estimate the association between current cigarette smoking and selected smoking-related variables. Study participants were recruited from middle and high schools in the United States. Logistic regression analysis using SUDAAN software was conducted to estimate the association between smoking and the following explanatory variables: age, sex, race-ethnicity, peer smoking, living in the same household as a smoker, amount of pocket money at the disposal of the adolescents, and perception that smoking is not harmful to health. Results Of the 27727 respondents whose data were analysed, 15.9% males and 15.3% females reported being current cigarette smokers. In multivariate analysis, compared to Whites, respondents from almost all ethnic groups were less likely to report current cigarette smoking: Blacks (OR = 0.52; 95% CI [0.44, 0.60]), Asians (OR = 0.45; 95% CI [0.35, 0.58]), Hispanic (OR = 0.81; 95% CI [0.71, 0.92]), and Hawaii/Pacific Islanders (OR = 0.69; 95% CI [0.52, 0.93]). American Indians were equally likely to be current smokers as whites, OR = 0.98 [95% CI; 0.79, 1.22]. Participants who reported living with a smoker were more than twice as likely to smoke as those who did not live with a cigarette smoker (OR = 2.73; 95% CI [2.21, 3.04]). Having friends who smoked was positively associated with smoking (OR = 2.27; 95% CI [1.91, 2.71] for one friend who smoked, and OR = 2.71; 95% CI [2.21, 3.33] for two or more friends who smoked). Subjects who perceived that it was safe to smoke for one or two years were more likely to smoke than those who thought it was definitely not safe to do so. There was a dose-response relationship between age and the amount of money available to the respondents on one hand, and current smoking status on the other (p-value < 0.001). Conclusion We found that White non-Hispanic adolescents were as likely to be current smokers as American Indians but more likely to be smokers than all other racial/ethnic groups. Older adolescents, increase amounts of pocket money, and perception that smoking was not harmful to health. The racial/ethnic differences in prevalence of smoking among America youth deserve particular exploration.
Complementary feeding: a Global Network cluster randomized controlled trial
Creators: name: Bose, Carl
name: Hartwell, Ty
name: Das, Abhik
name: Koso-Thomas, Marion
name: Wright, Linda L
name: Carlo, Waldemar
name: Goldenberg, Robert
name: Westcott, Jamie
name: Goco, Norman
name: McClure, Elizabeth
name: Hambidge, K Michael
name: Tshefu, Antoinette
name: Chomba, Elwyn
name: Krebs, Nancy F
name: Pasha, Omrana
name: Kindem, Mark
name: Mazariegos, Manolo
Publisher: name: BioMed Central Ltd
Year: 2011

description: Abstract Background Inadequate and inappropriate complementary feeding are major factors contributing to excess morbidity and mortality in young children in low resource settings. Animal source foods in particular are cited as essential to achieve micronutrient requirements. The efficacy of the recommendation for regular meat consumption, however, has not been systematically evaluated. Methods/Design A cluster randomized efficacy trial was designed to test the hypothesis that 12 months of daily intake of beef added as a complementary food would result in greater linear growth velocity than a micronutrient fortified equi-caloric rice-soy cereal supplement. The study is being conducted in 4 sites of the Global Network for Women's and Children's Health Research located in Guatemala, Pakistan, Democratic Republic of the Congo (DRC) and Zambia in communities with toddler stunting rates of at least 20%. Five clusters per country were randomized to each of the food arms, with 30 infants in each cluster. The daily meat or cereal supplement was delivered to the home by community coordinators, starting when the infants were 6 months of age and continuing through 18 months. All participating mothers received nutrition education messages to enhance complementary feeding practices delivered by study coordinators and through posters at the local health center. Outcome measures, obtained at 6, 9, 12, and 18 months by a separate assessment team, included anthropometry; dietary variety and diversity scores; biomarkers of iron, zinc and Vitamin B12 status (18 months); neurocognitive development (12 and 18 months); and incidence of infectious morbidity throughout the trial. The trial was supervised by a trial steering committee, and an independent data monitoring committee provided oversight for the safety and conduct of the trial. Discussion Findings from this trial will test the efficacy of daily intake of meat commencing at age 6 months and, if beneficial, will provide a strong rationale for global efforts to enhance local supplies of meat as a complementary food for young children. Trial registration NCT01084109
title: Albrecht Dürer: Die Druckgraphik: aus der Sammlung Otto Schäfer, Schweinfurt. Eine Ausstellung im Germanischen Nationalmuseum vom 21. September 2000 bis 9. Januar 2001
Creators: name: Schoch, Rainer
Publisher: name: University Library Heidelberg
Year: 2016

description: [nicht vorhanden / not available]
Optical Phase Curves of Kepler Exoplanets
Creators: name: Esteves, Lisa J.
name: De Mooij, Ernst J. W.
name: Jayawardhana, Ray
Publisher: name: arXiv
Year: 2013
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We have conducted a comprehensive search for optical phase variations of all planet candidates with tight orbits in fifteen quarters of data from the Kepler space telescope. After correcting for systematics, we found eight systems that appear to show secondary eclipses as well as phase variations. Of these, five (Kepler-5, Kepler-6, Kepler-8, KOI-64 and KOI-2133) are new and three (TrES-2, HAT-P-7 and KOI-13) have previously published phase curves, albeit with many fewer observations. We model the full phase curve of each planet candidate, including the primary and secondary transits, and derive their albedos, day- and night-side temperatures, ellipsoidal variations and Doppler beaming. We find that KOI-64 and KOI-2133 have night-side temperatures well above their equilibrium values (while KOI-2133 also has an albedo >1), so we conclude that they are likely to be self-luminous objects rather than planets. The characteristics of the six other candidates are consistent with their being planets with low geometric albedos (<0.3). For TrES-2 and KOI-13, the Kepler bandpass appears to probe atmospheric layers hotter than the planet's equilibrium temperature. For KOI-13, we detect a never-before-seen third cosine harmonic with an amplitude of 6.7+/-0.3 ppm and a phase shift of -1.1+/-0.1 radians in the phase curve residual, which could be due to its spin-orbit misalignment. We report derived planetary parameters for all six planets, including masses from ellipsoidal variations and Doppler beaming, and compare our results to published values when available. Our results nearly double the number of Kepler exoplanets with measured phase curve variations, thus providing valuable new constraints on the properties of close-in hot Jupiters.
description: Accepted for publication in ApJ
Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors
Creators: name: Choudhary, M. Salman
name: Craigo, Sean C.
name: Sibley, David R.
name: Roth, Bryan L.
name: Monsma, Frederick J., Jr.
name: Shen, Y.
name: Uluer, A.
name: Meltzer, Herbert Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1994

description: The authors examined the affinities of 36 typical and atypical antipsychotic agents for the cloned rat 5-hydroxytryptamine-6 (5-HT6) and rat 5-hydroxytryptamine-7 (5-HT7) receptors in transiently expressed COS-7 cells (5-HT7) or stably transfected HEK-293 cells (5-HT6 receptors). Clozapine and several related atypical antipsychotic agents (rilapine, olanzepine, tiospirone, fluperlapine, clorotepine and zotepine) had high affinities for the newly discovered 5-HT6 receptor (Kis less than 20 nM). The 5-HT7 receptor bound clozapine, rilapine, fluperlapine, clorotepine, zotepine and risperidone but not tiospirone and olanzepine, with affinities less than 15 nM. In addition, several typical antipsychotic agents (chloroprothixene, chlorpromazine, clothiapine and fluphenazine) had high affinities for both the 5-HT6 and 5-HT7 receptors. Pimozide, a diphenylbutylpiperidine, had the highest affinity of all the typical antipsychotic agents tested for the 5-HT7 receptor (Ki = 0.5 nM). Three putative atypical antipsychotic agents melperone, amperozide and MDL 100907 did not bind with high affinities to either the 5-HT6 or 5-HT7 receptors (Kis > 50 nM). Several dopamine-selective antipsychotic agents (raclopride, rimcazole and penfluridol) had essentially no affinity for either the 5-HT6 or 5-HT7 receptors (Ki values > 5000 nM).
AI AND BLOCKCHAIN IN FINANCE
Creators: name: Sharma, Arjuun
Publisher: name: figshare
Year: 2023
Subjects: Finance

description: Banking institutions' use of blockchain and AI has brought about profound changes in the delivery of banking services. Blockchain technology is a decentralised system that provides a safe and transparent means of storing and transferring data, while artificial intelligence (AI) can automate and simplify a number of financial procedures. The purpose of this research is to provide a critical analysis of the existing literature on blockchain and AI applications in banking, including a discussion of their potential benefits and drawbacks. The method employed for this work included a comprehensive evaluation of scholarly literature including journals, conference papers, and industry reports. The findings suggest that using blockchain technology and artificial intelligence in the financial sector might completely transform the market and make financial services more reliable, efficient, and cost-effective for everyone. Important challenges include overcoming regulatory limits, fears about personal information security, and the need for a skilled personnel. More research is needed to understand these challenges and provide solutions
Polish and Silesian Non-Profit Organizations Liquidity Strategies
Creators: name: Michalski, Grzegorz
name: Mercik, Aleksander
Publisher: name: arXiv
Year: 2013
Subjects: subject: General Finance (q-fin.GN)
subject: Risk Management (q-fin.RM)
subject: Statistical Finance (q-fin.ST)
subject: Applications (stat.AP)
subject: FOS: Economics and business
subject: FOS: Computer and information sciences

description: The kind of realized mission inflows the sensitivity to risk. Among other factors, the risk results from decision about liquid assets investment level and liquid assets financing. The higher the risk exposure, the higher the level of liquid assets. If the specific risk exposure is smaller, the more aggressive could be the net liquid assets strategy. The organization choosing between various solutions in liquid assets needs to decide what level of risk is acceptable for her owners (or donors) and / or capital suppliers. The paper shows how, in authors opinion, decisions, about liquid assets management strategy inflow the risk of the organizations and its economical results during realization of main mission. Comparison of theoretical model with empirical data for over 450 Silesian nonprofit organization results suggests that nonprofit organization managing teams choose more risky aggressive liquid assets solutions than for-profit firms.
Aria X Mougeotii
Creators: name: Becherer
Publisher: name: Zenodo
Year: 1956
Subjects: Biodiversity
Taxonomy

description: S. Aria X Mougeotii - l: La Crottaz, Grenze Waadt-Wallis (Bürdet). - 2: La Giete Dele ob Ayent (P.); Ertense unter der Bellalui (P.). - 3: Visp-Stalden(P.).
description: Published as part of Becherer, 1956, Florae Vallesiacae Supplementum, pp. 1-556 in Denkschriften der Schweizerischen Naturforschenden Gesellschaft 71 on pages 1-556
Possible existence of viable models of bi-gravity with detectable graviton oscillations by gravitational wave detectors
Creators: name: De Felice, Antonio
name: Nakamura, Takashi
name: Tanaka, Takahiro
Publisher: name: arXiv
Year: 2013
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We discuss graviton oscillations based on the ghost free bi-gravity theory. We point out that this theory possesses a natural cosmological background solution which is very close to the case of general relativity. Furthermore, interesting parameter range of the graviton mass, which can be explored by the observations of gravitational waves, is not at all excluded by the constraint from the solar system tests. Therefore the graviton oscillation with possible inverse chirp signal would be an interesting scientific target of KAGRA, adv LIGO, adv Virgo and GEO.
description: 5 pages, 3 figures
Safety and pharmacodynamic effects of a pharmacological chaperone on α-galactosidase A activity and globotriaosylceramide clearance in Fabry disease: report from two phase 2 clinical studies
Creators: name: Barisoni, Laura
name: Germain, Dominique P
name: Bragat, Alexander
name: Lockhart, David J
name: Mehta, Atul
name: Boudes, Pol F
name: Giugliani, Roberto
name: Sitaraman, Sheela
name: Jennette, Charles
name: Nicholls, Kathy
name: Castelli, Jeff
name: Hughes, Derralynn A
Publisher: name: BioMed Central Ltd
Year: 2012

description: Abstract Background Fabry disease (FD) is a genetic disorder resulting from deficiency of the lysosomal enzyme α-galactosidase A (α-Gal A), which leads to globotriaosylceramide (GL-3) accumulation in multiple tissues. We report on the safety and pharmacodynamics of migalastat hydrochloride, an investigational pharmacological chaperone given orally at 150 mg every-other-day. Methods Two open-label uncontrolled phase 2 studies of 12 and 24 weeks (NCT00283959 and NCT00283933) in 9 males with FD were combined. At multiple time points, α-Gal A activity and GL-3 levels were quantified in blood cells, kidney and skin. GL-3 levels were also evaluated through skin and renal histology. Results Compared to baseline, increased α-Gal A activity of at least 50% was demonstrated in blood, skin and kidney in 6 of 9 patients. Patients’ increased α-Gal A activities paralleled the α-Gal A increases observed in vitro in HEK-293 cells transfected with the corresponding mutant form of the enzyme. The same 6 patients who demonstrated increases of α-Gal A activity also had GL-3 reduction in skin, urine and/or kidney, and had α-Gal A mutations that responded in transfected cells incubated with the drug. The 3 patients who did not show a consistent response in vivo had α-Gal A mutations that did not respond to migalastat HCl in transfected cells. Migalastat HCl was well tolerated. Conclusions Migalastat HCl is a candidate pharmacological chaperone that provides a novel genotype-specific treatment for FD. It enhanced α-Gal A activity and resulted in GL-3 substrate decrease in patients with responsive GLA mutations. Phase 3 studies are ongoing. Trial registration Clinicaltrial.gov: NCT00283959 and NCT00283933
Holographic Hierarchy in the Gaussian Matrix Model via the Fuzzy Sphere
Creators: name: Garner, David
name: Ramgoolam, Sanjaye
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The Gaussian Hermitian matrix model was recently proposed to have a dual string description with worldsheets mapping to a sphere target space. The correlators were written as sums over holomorphic (Belyi) maps from worldsheets to the two-dimensional sphere, branched over three points. We express the matrix model correlators by using the fuzzy sphere construction of matrix algebras, which can be interpreted as a string field theory description of the Belyi strings. This gives the correlators in terms of trivalent ribbon graphs that represent the couplings of irreducible representations of su(2), which can be evaluated in terms of 3j and 6j symbols. The Gaussian model perturbed by a cubic potential is then recognised as a generating function for Ponzano-Regge partition functions for 3-manifolds having the worldsheet as boundary, and equipped with boundary data determined by the ribbon graphs. This can be viewed as a holographic extension of the Belyi string worldsheets to membrane worldvolumes, forming part of a holographic hierarchy linking, via the large N expansion, the zero-dimensional QFT of the Matrix model to 2D strings and 3D membranes.
description: 81 pages, 33 figures
Recovering partial conservation of axial current in diffractive neutrino scattering
Creators: name: Novikov, V. A.
name: Zoller, V. R.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: A model of diffractive neutrino scattering is formulated in terms of the chiral hadronic current which is conserved in the limit of vanishing pion mass. This current has the correct singularity structure and, naturally, does not lead to contradictions with a partial conservation of the axial current (PCAC). In that respect we differ from earlier work in the literature, where a breakdown of PCAC had been reported. We show that such a breakdown of PCAC is an artifact of the hadronic current non-conservation in the model developed there.
description: 7 pages
Evaluation of high-resolution melting and RT-qPCR probe assays for high-throughput detection of target-site mutations conferring glyphosate resistance in Lolium perenne
Creators: name: Ghanizadeh, Hossein
name: Anderson, Craig
name: Franzmayr, Benjamin
name: Cook, Mike
name: Buddenhagen, Chris
name: Ngow, Zachary
name: James, Trevor
name: Griffiths, Andrew
Publisher: name: AgResearch
Year: 2023
Subjects: Plant biology

description: Rapid identification of herbicide-resistant weeds plays a crucial role in their management. Glyphosate resistance in Lolium perenne is a growing issue in New Zealand and can be conferred by a single nucleotide polymorphism (SNP) causing amino acid substitutions at codon 106 in the 5-enolpyruvoylshikimate-3-phosphate synthase (EPSPS) gene. High-throughput molecular (HTM) methodologies that can detect such SNPs include high-resolution melting and real-time quantitative PCR probe assays. Here, we compare the effectiveness of both assays with a more labour-intense derived cleaved amplified polymorphic sequence (dCAPS) test for detecting SNPs at codon 106. The results showed that both HTM assays detected mutations at this codon, and their results were consistent with those of the dCAPS. Unlike dCAPS, however, the HTM assays over-estimated homozygosity for the glyphosate resistance allele. Nevertheless, cost-effective high-throughput detection of resistance is more important than the zygosity status when initiating an on-farm management response. In summary, both HTM assays successfully identified glyphosate resistance alleles at codon 106 in the EPSPS gene. Given that both assays are more cost-effective and can screen a larger number of samples in a timely manner compared to the dCAPS method, they can be used as quick tests for detecting glyphosate resistance in L. perenne.
A Case Study of the First Proposed Field Test of an Environmental Application of Biotechnology in the United States
Creators: name: Naimon, Johnathan S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1987

description: This paper analyzes the processes by which three levels of government analyzed potential risks from a precedent setting environmental application of biotechnology, Advanced Genetic Science's FROSTBAN product. The research is based on regulatory decision dockets, accounts of the case in scientific journals and newspapers, and personal interviews with key scientists, policy analysts, and senior decision makers. The 1.5 hour interviews employed both fixed choice and open-ended questions. Four distinct conceptions of potential hazards arose in the AGS case: toxicity to humans, pathogenicity to plants, ecological risks to non target species, and climate changes. Worst case scenarios were devised in each organization to evaluate the application. The scientific assumptions of these analyses differed substantially. All three organizations requested additional technical data from AGS. Criteria for evaluating such data were not always prepared before performing experiments. Scientists believed the most critical uncertainties related to their individual discipline. Many of the uncertainties identified in the AGS case could not be unambiguously resolved by provision of more data. A framework for interpreting information on potential ecological hazards of introduced organisms is not available from any one of the disciplines that contributed to the AGS review. Future risk analyses could be improved by developing explicit ecological goals and criteria for data interpretation. In the meantime, biological controls should be required for tests of engineered microorganisms to reduce many identified uncertainties.
NanoConstruct: A toolbox for the digital reconstruction of Energy Minimized NanoParticles, Nanosheets and NanoTubes Powered by Enalos Cloud Platform
Creators: name: Kolokathis, Panagiotis D.
name: Sidiropoulos, Nikolaos K.
name: Tsoumanis, Andreas
name: Papadiamantis, Anastasios G.
name: Lynch, Iseult
name: Afantitis, Antreas
Publisher: name: Zenodo
Year: 2023

description: Computational tools have been widely used for predicting material properties in the past. Nowadays, the rapid development of computers has increased interest in these tools due to their speed and low cost compared to physical experiments. Furthermore, mixing nanomaterials with other materials to create sols, emulsions, gels, or foams can lead to improved material properties. Efficient computational screening techniques are needed to quickly discover the most promising combinations. Atomistic simulations can be used for the screening process after digitally reconstructing the systems to be investigated. However, digitally reconstructing systems containing secondary phases, such as Nanoparticles (NPs), Nanosheets (NSs), and/or Nanotubes (NTs), is not a straightforward task. NanoConstruct (http://enaloscloud.novamechanics.com/diagonal/nanotube/), a toolbox powered by the Enalos Cloud Platform (enaloscloud.novamechanics.com), has been developed to overcome this barrier. NanoConstruct uses Crystallographic Information Files available on crystallographic databases as input to geometrically reconstruct crystalline NPs, while maintaining stoichiometry by removing excess atoms on the surface. Additionally, NanoConstruct searches the OPENKIM database and selects the Force-Field (FF) that is less generic and simultaneously contains every chemical element of the NP. The option to select a different OPENKIM FF than the suggested one is also available. After the FF selection, energy minimization is applied to investigate the NP's stability, while several descriptors are calculated for subsequent Machine Learning analysis. A similar procedure is applied for the NS and NT construction.
Top-Quark Charge Asymmetry Goes Forward: Two New Observables for Hadron Colliders
Creators: name: Berge, Stefan
name: Westhoff, Susanne
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We propose two new observables to measure the charge asymmetry in hadronic top-quark pair production in association with a hard jet. The incline asymmetry, based on the inclination between the planes of initial- and final-state momenta, probes the charge asymmetry in the quark-antiquark channel. Compared to the hitherto investigated rapidity asymmetries, the incline asymmetry provides improved access to the partonic charge asymmetry at both the Tevatron and the LHC. The energy asymmetry, based on the energy difference between top and antitop quarks, for the first time allows us to probe the charge asymmetry in the quark-gluon channel at the LHC. In quantum chromodynamics, asymmetries of up to -12% at the leading order are achievable with appropriate cuts. Top-pair plus jet production thus has the potential to become the discovery channel of the charge asymmetry in proton-proton collisions.
description: 32 pages, 12 figures, 5 tables
Magnetic Dynamics of a Multiferroic with an Antiferromagnetic Layer
Creators: name: Kondovych, Svitlana V.
name: Gomonay, Helen V.
name: Loktev, Vadim M.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Shape effects in magnetic particles are widely studied, because of the ability of the shape and the size to control the parameters of a sample during its production. Experiments with nano-sized samples show that the shape can affect also the properties of antiferromagnetic (AFM) materials. However, the theoretical interpretation of these effects is under discussion. We propose a model to study the shape-induced effects in AFM particles at the AFM resonance frequency. The Lagrange function method is used to calculate the spectrum of resonance oscillations of the AFM vector in a synthetic multiferroic (piezoelectric + antiferromagnet). The influence of the specimen shape on the AFM resonance frequency in the presence of an external magnetic field is studied. Conditions for a resonance under the action of an external force or for a parametric resonance to arise in the magnetic subsystem are considered.
description: 10 pages, 5 figures
Value-Based Inventory Management
Creators: name: Michalski, Grzegorz
Publisher: name: arXiv
Year: 2013
Subjects: subject: Portfolio Management (q-fin.PM)
subject: FOS: Economics and business
subject: 91G50

description: The basic financial purpose of a firm is to maximize its value. An inventory management system should also contribute to realization of this basic aim. Many current asset management models currently found in financial management literature were constructed with the assumption of book profit maximization as basic aim. However these models could lack what relates to another aim, i.e., maximization of enterprise value. This article presents a modified value-based inventory management model.
description: no coments
Performance of a random-access wireless network with a mix of full- and half-duplex stations
Creators: name: Aggarwal, Vaneet
name: Shankaranarayanan, N. K.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Information Theory (cs.IT)
subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: In this paper, we consider the performance of a random-access time-slotted wireless network with a single access point and a mix of half- and full- duplex stations. Full-duplex transmissions involve data transmitted simultaneously in both directions, and this influences the dynamics of the queue at the access point. Given the probabilities of channel access by the nodes, this paper provides generalized analytical formulations for the throughputs for each station. Special cases related to a 802.11 DCA based system as well as a full-fairness system are discussed, which provide insights into the changes introduced by the new technology of full-duplex wireless.
description: 9 pages, submitted to IEEE Communication Letters
Availability of supplies and motivations for use of voluntary HIV counseling and testing services in Blantyre, Malawi
Creators: name: Muula, Adamson S
name: Jereni, Bwanali H
Publisher: name: BioMed Central Ltd
Year: 2008

description: Abstract Background HIV counseling and testing is an important intervention in the prevention, control and management of the human immunodeficiency virus (HIV). Counseling and testing can be an entry point for prevention, care and support. Knowledge of the quality of services and motivations for testing by individuals is important for effective understanding of the testing environment. Methods A cross sectional explorative study of clients accessing HIV voluntary counseling and testing (VCT) and counselors was conducted in 6 government health centers in Blantyre City, Malawi. We aimed to assess the availability of critical clinic supplies and identify the motivations of clients seeking counseling and testing services. We also aimed to identify the health professional cadres that were providing VCT in Blantyre city. Results 102 VCT clients and 26 VCT counselors were interviewed. Among the VCT clients, 74% were <=29 years, 58.8% were females and only 7% reported no formal education. 42.2% were single, 45.1% married, 8.8% widowed and 3.9% divorced or separated. The primary reasons for seeking HIV counseling and testing were: recent knowledge about HIV (31.4%), current illness (22.5%), self-assessment of own behavior as risky (15.5%), suspecting sexual partner's infidelity (13.7%) and seeking HIV confirmatory test (9.8%) and other reasons (6.9%). Of the 26 VCT counselors, 14 were lay volunteers, 7 health surveillance assistants and 5 nurses. All except one had been trained specifically for HIV counseling and testing. All 6 facilities were conducting rapid HIV testing with same day test results provided to clients. Most of the supplies were considered adequate for testing. Conclusion HIV counseling and testing facilities were available in Blantyre city in all the six public health facilities assessed. The majority of counseling and testing clients were motivated by perceptions of being at risk of HIV infection. In a country with 12% of individuals 15 to 49 years infected, there is need to encourage testing among population groups that may not perceive themselves to be at risk of infection.
Interactions of Bispyridinium compounds with the DOPC Membrane as revealed by Constraint Dynamics Simulations and Rapid Cyclic Voltammetry
Creators: name: Kolokathis, Panagiotis D.
name: William, Nicola
name: Timperley, Christopher M.
name: Bird, Mike
name: Tattersall, John
name: Nelson, Andrew
name: Afantitis, Antreas
Publisher: name: Zenodo
Year: 2023

description: Bispyridinium compounds (BPCs) have important applications as potential pharmaceuticals and antidotes for nerve agent poisoning. These compounds consist of two pyridinium groups linked via the nitrogen atom by an alkyl chain of varying length, while t-butyl groups can substitute the hydrogen atoms of the pyridinium groups. The length of the alkyl chain and the presence or absence of t-butyl groups influence the interactions of BPCs with membranes. These selective interactions of the BPCs with membranes allow us to use the membranes as sensors to trace specific BPCs in blood, water, or other solutions. To confirm the selectivity of membranes to BPCs, we studied the interaction of six BPCs (i.e., having alkyl chain lengths of 1, 5, and 10 with or without t-butyl groups) with the 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) bilayer membrane when both are in water. We applied Rapid Cyclic Voltammetry (RCV) and Constraint Dynamics Simulations to create rapid cyclic voltammograms and to find the free energy profiles, respectively. Since BPCs have a positive charge of +2e, two negative anions (in our study, iodine anions I-) coexist in the solution. Different BPCs led to differences in the RCV voltammograms (e.g., depression of the capacitance peaks). These differences were further studied by Atomistic Simulations under the influence of an external electric field. Atomistic Simulations revealed a transition from the initial DOPC bilayer orientation to a new one, perpendicular to the first. In the absence of an external electric field, the free energy barriers were larger than 30 kcal/mol for all the examined systems, indicating that it is extremely rare for a BPC to pass through the DOPC membrane. Additionally, the free energy profiles reveal that BPCs prefer to reside in water, followed by the polar part of the DOPC membrane, while BPCs do not prefer the hydrophobic part of the DOPC membrane.
Spectral large sieve inequalities for Hecke congruence subgroups of SL(2,Z[i])
Creators: name: Watt, Nigel
Publisher: name: arXiv
Year: 2013
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11F30, 11F37, 11F70, 11F72, 11L05, 11L07, 11M41, 11N35, 11R42, 22E30, 33C10, 44A15

description: We prove, in respect of an arbitrary Hecke congruence subgroup Γ=Γ_0(q_0) of the group SL(2,Z[i]), some new upper bounds (or `spectral large sieve inequalities') for sums involving Fourier coefficients of Γ-automorphic cusp forms on SL(2,C). The Fourier coefficients in question may arise from the Fourier expansion at any given cusp c of Γ: our results are not limited to the case in which c is the cusp at infinity. For this reason, our proof is reliant upon an extension, to arbitrary cusps, of the spectral-Kloosterman sum formula for Γ\SL(2,C) obtained by Hristina Lokvenec-Guleska in her doctoral thesis (generalising the sum formulae of Roelof Bruggeman and Yoichi Motohashi for PSL(2,Z[i])\PSL(2,C) in several respects, though not as regards the choice of cusps). A proof of the required extension of the sum formula is given in an appendix.
description: 137 pages, 0 figures
title: A Merovingian Spatha from Mannheim
Creators: name: Röber, Christopher
Publisher: name: University Library Heidelberg
Year: 2016

description: Für die Ausstellung »Wilde Völker an Rhein und Neckar: Franken im frühen Mittelalter« in Mannheim wurde die Spatha eines Reiters des 6. Jahrhunderts restauriert und konserviert. Die Objektbeschreibung wird durch Röntgenbilder
und CT-Aufnahmen ergänzt. REM-EDX Untersuchungen am silbernen Spathaknauf zeigen Reste einer Feuervergoldung sowie Einlagen aus Niello an. Verwendete
Materialien und Techniken weisen die Spatha deutlich als Produkt des frühen Mittelalters aus.
description: For the exhibition »Wilde Völker an Rhein und Neckar: Franken im frühen Mittelalter« in Mannheim, the spatha of a 6th century rider was restored and conserved. The object description is complemented by X-rays images and CT
scans. SEM-EDX studies on the pommel made of silver indicate remains of fire gilding and niello inlays. The materials and techniques used classify the spatha as a product of the early Middle Ages.
Citizen Science, Open Science & Community Engaged Learning  Burgers actief betrekken in en met de Stad
Creators: name: Gold, Margaret
Publisher: name: Zenodo
Year: 2023

description: De 2023 landelijke CDKM-kennisdelingsdag en kick-off vondt plaats op maandag 13 november in 's-Hertogenbosch. Op deze dag kwamen onderwijs- en onderzoeksvernieuwers van binnen en buiten het CDKM-netwerk samen voor een inspirerende dag vol inspirerende deelsessies en excursies.
In deze lezing sprak Margaret Gold van Universiteit Leiden en het Leiden Kennis Stad partnerschap over burgerwetenschap als overkoepelende term voor een reeks partipatoire onderzoekspraktijken, hun synergie met open science en publieke betrokkenheid bij wetenschap en 'community engaged learning' -  en twee specifieke voorbeelden in Leiden van buurtbewoners die lichtvervuiling en luchtvervuiling onderzoeken.
Bright solitons in quasi-one dimensional dipolar condensates with spatially modulated interactions
Creators: name: Abdullaev, Fatkhulla Kh.
name: Gammal, Arnaldo
name: Malomed, Boris A.
name: Tomio, Lauro
Publisher: name: arXiv
Year: 2013
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Pattern Formation and Solitons (nlin.PS)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We introduce a model for the condensate of dipolar atoms or molecules, in which the dipole-dipole interaction (DDI) is periodically modulated in space, due to a periodic change of the local orientation of the permanent dipoles, imposed by the corresponding structure of an external field (the necessary field can be created, in particular, by means of magnetic lattices, which are available to the experiment). The system represents a realization of a nonlocal nonlinear lattice, which has a potential to support various spatial modes. By means of numerical methods and variational approximation (VA), we construct bright one-dimensional solitons in this system, and study their stability. In most cases, the VA provides good accuracy, and correctly predicts the stability by means of the Vakhitov-Kolokolov (VK)\ criterion. It is found that the periodic modulation may destroy some solitons, which exist in the usual setting with unmodulated DDI, and can create stable solitons in other cases, not verified in the absence of modulations. Unstable solitons typically transform into persistent localized breathers. The solitons are often mobile, with inelastic collisions between them leading to oscillating localized modes.
description: To appear in Physical Review A (2013). 24 pages (preprint format), 13 figures