cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Genome-Wide Meta-Analysis Identifies Regions on 7p21 (AHR) and 15q24 (CYP1A2) As Determinants of Habitual Caffeine Consumption
Creators: name: van Dam, Rob M.
name: Nettleton, Jennifer A.
name: Couper, David
name: Landi, Maria Teresa
name: Silverman, Debra
name: Curhan, Gary
name: Cornelis, Marilyn C.
name: Stolzenberg-Solomon, Rachael
name: Chanock, Stephen
name: Rajaraman, Preetha
name: Jacobs, Kevin
name: Heiss, Gerardo
name: Kraft, Peter
name: Berndt, Sonja I.
name: Hunter, David J.
name: Paynter, Nina
name: Yu, Kai
name: Caporaso, Neil E.
name: Monda, Keri L.
name: Rimm, Eric B.
name: Azzato, Elizabeth M.
name: Rothman, Nathaniel
name: Chatterjee, Nilanjan
name: Hu, Frank B.
name: Boerwinkle, Eric
name: Jensen, Majken K.
name: Yeager, Meredith
name: Purdue, Mark P.
name: Bennett, Siiri N.
name: Chasman, Daniel I.
name: Subar, Amy
name: Rose, Lynda M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: We report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States. In a meta-analysis adjusted for age, sex, smoking, and eigenvectors of population variation, two loci achieved genome-wide significance: 7p21 (P = 2.4×10−19), near AHR, and 15q24 (P = 5.2×10−14), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2.
Massive "spin-2" theories in arbitrary $D \ge 3$ dimensions
Creators: name: Dalmazi, D.
name: Santos, A. L. R. dos
name: Mendonça, E. L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Here we show that in arbitrary dimensions $D\ge 3$ there are two families of second order Lagrangians describing massive "spin-2" particles via a nonsymmetric rank-2 tensor. They differ from the usual Fierz-Pauli theory in general. At zero mass one of the families is Weyl invariant. Such massless theory has no particle content in $D=3$ and gives rise, via master action, to a dual higher order (in derivatives) description of massive spin-2 particles in $D=3$ where both the second and the fourth order terms are Weyl invariant, contrary to the linearized New Massive Gravity. However, only the fourth order term is invariant under arbitrary antisymmetric shifts. Consequently, the antisymmetric part of the tensor $e_{[μν]}$ propagates at large momentum as $1/p^2$ instead of $1/p^4$. So, the same kind of obstacle for the renormalizability of the New Massive Gravity reappears in this nonsymmetric higher order description of massive spin-2 particles.
description: 11 pages, 0 figures
Identification of Nine Novel Loci Associated with White Blood Cell Subtypes in a Japanese Population
Creators: name: Matsuda, Koichi
name: Tamari, Mayumi
name: Hirota, Tomomitsu
name: Kamatani, Naoyuki
name: O'Donnell, Christopher J.
name: Chen, Ming Huei
name: Higasa, Koichiro
name: Yamamoto, Kazuhiko
name: Longo, Dan L.
name: Ohmiya, Hiroko
name: Harris, Tamara B.
name: Yamaguchi-Kabata, Yumi
name: Smith, Albert V.
name: Kubo, Michiaki
name: Witteman, Jacqueline C. M.
name: Tanaka, Toshihiro
name: Kamatani, Yoichiro
name: Okada, Yukinori
name: van Rooij, Frank J. A.
name: Ferrucci, Luigi
name: Nalls, Michael A.
name: Tanaka, Toshiko
name: Hernandez, Dena G.
name: Nakamura, Yusuke
name: Tsunoda, Tatsuhiko
name: Takahashi, Atsushi
name: Hosono, Naoya
name: Ganesh, Santhi K.
name: Couper, David J.
name: Zakai, Neil A.
name: Kumasaka, Natsuhiko
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: White blood cells (WBCs) mediate immune systems and consist of various subtypes with distinct roles. Elucidation of the mechanism that regulates the counts of the WBC subtypes would provide useful insights into both the etiology of the immune system and disease pathogenesis. In this study, we report results of genome-wide association studies (GWAS) and a replication study for the counts of the 5 main WBC subtypes (neutrophils, lymphocytes, monocytes, basophils, and eosinophils) using 14,792 Japanese subjects enrolled in the BioBank Japan Project. We identified 12 significantly associated loci that satisfied the genome-wide significance threshold of P<5.0×10−8, of which 9 loci were novel (the CDK6 locus for the neutrophil count; the ITGA4, MLZE, STXBP6 loci, and the MHC region for the monocyte count; the SLC45A3-NUCKS1, GATA2, NAALAD2, ERG loci for the basophil count). We further evaluated associations in the identified loci using 15,600 subjects from Caucasian populations. These WBC subtype-related loci demonstrated a variety of patterns of pleiotropic associations within the WBC subtypes, or with total WBC count, platelet count, or red blood cell-related traits (n = 30,454), which suggests unique and common functional roles of these loci in the processes of hematopoiesis. This study should contribute to the understanding of the genetic backgrounds of the WBC subtypes and hematological traits.
Phase Diagram in Stored-Energy-Driven Lévy Flight
Creators: name: Akimoto, Takuma
name: Miyaguchi, Tomoshige
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Phase diagram based on the mean square displacement (MSD) and the distribution of diffusion coefficients of the time-averaged MSD for the stored-energy-driven Lévy flight (SEDLF) is presented. In the SEDLF, a random walker cannot move while storing energy, and it jumps by the stored energy. The SEDLF shows a whole spectrum of anomalous diffusions including subdiffusion and superdiffusion, depending on the coupling parameter between storing time (trapping time) and stored energy. This stochastic process can be investigated analytically with the aid of renewal theory. Here, we consider two different renewal processes, i.e., ordinary renewal process and equilibrium renewal process, when the mean trapping time does not diverge. We analytically show the phase diagram according to the coupling parameter and the power exponent in the trapping-time distribution. In particular, we find that distributional behavior of time-averaged MSD intrinsically appears in superdiffusive as well as normal diffusive regime even when the mean trapping time does not diverge.
description: 9 pages, 3 figures
Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Coronary artery disease (CAD) has a significant genetic contribution that is incompletely characterized. To complement genome-wide association (GWA) studies, we conducted a large and systematic candidate gene study of CAD susceptibility, including analysis of many uncommon and functional variants. We examined 49,094 genetic variants in ∼2,100 genes of cardiovascular relevance, using a customised gene array in 15,596 CAD cases and 34,992 controls (11,202 cases and 30,733 controls of European descent; 4,394 cases and 4,259 controls of South Asian origin). We attempted to replicate putative novel associations in an additional 17,121 CAD cases and 40,473 controls. Potential mechanisms through which the novel variants could affect CAD risk were explored through association tests with vascular risk factors and gene expression. We confirmed associations of several previously known CAD susceptibility loci (eg, 9p21.3:p<10−33; LPA:p<10−19; 1p13.3:p<10−17) as well as three recently discovered loci (COL4A1/COL4A2, ZC3HC1, CYP17A1:p<5×10−7). However, we found essentially null results for most previously suggested CAD candidate genes. In our replication study of 24 promising common variants, we identified novel associations of variants in or near LIPA, IL5, TRIB1, and ABCG5/ABCG8, with per-allele odds ratios for CAD risk with each of the novel variants ranging from 1.06–1.09. Associations with variants at LIPA, TRIB1, and ABCG5/ABCG8 were supported by gene expression data or effects on lipid levels. Apart from the previously reported variants in LPA, none of the other ∼4,500 low frequency and functional variants showed a strong effect. Associations in South Asians did not differ appreciably from those in Europeans, except for 9p21.3 (per-allele odds ratio: 1.14 versus 1.27 respectively; P for heterogeneity = 0.003). This large-scale gene-centric analysis has identified several novel genes for CAD that relate to diverse biochemical and cellular functions and clarified the literature with regard to many previously suggested genes.
Global orthogonal spectra
Creators: name: Bohmann, Anna Marie
Publisher: name: arXiv
Year: 2012
Subjects: subject: Algebraic Topology (math.AT)
subject: Category Theory (math.CT)
subject: FOS: Mathematics
subject: 55P91, 55P42 (Primary) 55U40 (Secondary)

description: For any finite group G, there are several well-established definitions of a G-equivariant spectrum. In this paper, we develop the definition of a global orthogonal spectrum. Loosely speaking, this is a coherent choice of orthogonal G-spectrum for each finite group G. We use the framework of enriched indexed categories to make this precise. We also consider equivariant K-theory and Spin^c-cobordism from this perspective, and we show that the Atiyah--Bott--Shapiro orientation extends to the global context.
description: 17 pages
The Global versus Local Hamiltonian Description of Quantum Input-Output Theory
Creators: name: Gough, John E.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The aim of this paper is to derive the global Hamiltonian form for a quantum system and bath, or more generally a quantum network with multiple quantum input field connections, based on the local descriptions. We give a new simple argument which shows that the global Hamiltonian for a single Markov component arises as the singular perturbation of the free translation operator. We show that the Fermi analogue takes an equivalent form provided the parity of the coefficients is correctly specified. This allows us to immediately extend the theory of quantum feedback networks to Fermi systems.
description: 12 pages, 3 figures. Section on classical environments for quantum systems added. arXiv admin note: text overlap with arXiv:1404.3182
Multiple Loci Are Associated with White Blood Cell Phenotypes
Creators: name: Biffi, Alessandro
name: Lagou, Vasiliki
name: Taylor, Kent
name: Toniolo, Daniela
name: Völker, Uwe
name: Wilson, James G.
name: Dehghan, Abbas
name: Gasparini, Paolo
name: Gieger, Christian
name: Chen, Ming-Huei
name: Liu, Yongmei
name: Smith, Albert V.
name: Chong, Sean
name: Gouskova, Natalia A.
name: Felix, Janine F.
name: Rendon, Augusto
name: Yang, Qiong
name: Moore, Matt
name: Greinacher, Andreas
name: Völzke, Henry
name: Wood, Andrew R.
name: Tanaka, Toshiko
name: van Rooij, Frank J. A.
name: Döring, Angela
name: Couper, David J.
name: Zakai, Neil A.
name: Wiggins, Kerri L.
name: Nalls, Michael A.
name: Garcia, Melissa
name: Reiner, Alex P.
name: Folsom, Aaron R.
name: Lumley, Thomas
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: White blood cell (WBC) count is a common clinical measure from complete blood count assays, and it varies widely among healthy individuals. Total WBC count and its constituent subtypes have been shown to be moderately heritable, with the heritability estimates varying across cell types. We studied 19,509 subjects from seven cohorts in a discovery analysis, and 11,823 subjects from ten cohorts for replication analyses, to determine genetic factors influencing variability within the normal hematological range for total WBC count and five WBC subtype measures. Cohort specific data was supplied by the CHARGE, HeamGen, and INGI consortia, as well as independent collaborative studies. We identified and replicated ten associations with total WBC count and five WBC subtypes at seven different genomic loci (total WBC count—6p21 in the HLA region, 17q21 near ORMDL3, and CSF3; neutrophil count—17q21; basophil count- 3p21 near RPN1 and C3orf27; lymphocyte count—6p21, 19p13 at EPS15L1; monocyte count—2q31 at ITGA4, 3q21, 8q24 an intergenic region, 9q31 near EDG2), including three previously reported associations and seven novel associations. To investigate functional relationships among variants contributing to variability in the six WBC traits, we utilized gene expression- and pathways-based analyses. We implemented gene-clustering algorithms to evaluate functional connectivity among implicated loci and showed functional relationships across cell types. Gene expression data from whole blood was utilized to show that significant biological consequences can be extracted from our genome-wide analyses, with effect estimates for significant loci from the meta-analyses being highly corellated with the proximal gene expression. In addition, collaborative efforts between the groups contributing to this study and related studies conducted by the COGENT and RIKEN groups allowed for the examination of effect homogeneity for genome-wide significant associations across populations of diverse ancestral backgrounds.
Jointly Predicting Emotion, Age, and Country Using Pre-Trained Acoustic Embedding
Creators: name: Atmaja, Bagus Tris
name: Zanjabila
name: Sasou, Akira
Publisher: name: arXiv
Year: 2022
Subjects: subject: Audio and Speech Processing (eess.AS)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In this paper, we demonstrated the benefit of using pre-trained model to extract acoustic embedding to jointly predict (multitask learning) three tasks: emotion, age, and native country. The pre-trained model was trained with wav2vec 2.0 large robust model on the speech emotion corpus. The emotion and age tasks were regression problems, while country prediction was a classification task. A single harmonic mean from three metrics was used to evaluate the performance of multitask learning. The classifier was a linear network with two independent layers and shared layers, including the output layers. This study explores multitask learning on different acoustic features (including the acoustic embedding extracted from a model trained on an affective speech dataset), seed numbers, batch sizes, and normalizations for predicting paralinguistic information from speech.
Mentoring through scholarship-based academic development projects
Creators: name: Robbie, Diane
name: Weaver, Debbi
Publisher: name: La Trobe
Year: 2023

description: This paper outlines the use of WebCT in a collaborative assessment project between an Australian and two US universities. Informed by global trends, criminal justice practitioners increasingly move through different jurisdictions and cultural contexts. We wanted to work with students and have students work with each other in ways that prepared them to operate in international surroundings in relation to international law and the transnationalisation of criminal justice agencies. The Global Project required students to engage in a series of online activities with the aim of fostering online and international co -operation between students. Moreover, as students were studying globalisation and criminal justice, it was designed to engage students in the processes and experiences of globalisation. The use of online learning technologies in fostering the internationalisation of curriculum and developing alternative group learning strategies has offered a series of challenges which require critical reflection on the ways we globalise learning.
Young Stellar Population of the Bright-Rimmed Clouds BRC 5, BRC 7 and BRC 39
Creators: name: Panwar, Neelam
name: Chen, W. P.
name: Pandey, A. K.
name: Samal, M. R.
name: Ogura, K.
name: Ojha, D. K.
name: Jose, J.
name: Bhatt, B. C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Bright-rimmed clouds (BRCs), illuminated and shaped by nearby OB stars, are potential sites of recent/ongoing star formation. Here we present an optical and infrared photometric study of three BRCs: BRC 5, BRC 7 and BRC 39 to obtain a census of the young stellar population, thereby inferring the star formation scenario, in these regions. In each BRC, the Class I sources are found to be located mostly near the bright rim or inside the cloud, whereas the Class II sources are preferentially outside, with younger sources closer to the rim. This provides strong support to sequential star formation triggered by radiation driven implosion due to the UV radiation. Moreover, each BRC contains a small group of young stars being revealed at its head, as the next-generation stars. In particular, the young stars at the heads of BRC 5 and BRC 7 are found to be intermediate/high mass stars, which, under proper conditions, may themselves trigger further star birth, thereby propagating star formation out to long distances.
description: 30 pages, 7 Figures, 6 Tables, accepted for publication in Monthly Notices of the Royal Astronomical Society
Three Structure-Selective Endonucleases Are Essential in the Absence of BLM Helicase in Drosophila
Creators: name: Brodsky, Michael H.
name: Andersen, Sabrina L.
name: Sekelsky, Jeff
name: Kuo, H. Kenny
name: Savukoski, Daniel
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: DNA repair mechanisms in mitotically proliferating cells avoid generating crossovers, which can contribute to genome instability. Most models for the production of crossovers involve an intermediate with one or more four-stranded Holliday junctions (HJs), which are resolved into duplex molecules through cleavage by specialized endonucleases. In vitro studies have implicated three nuclear enzymes in HJ resolution: MUS81–EME1/Mms4, GEN1/Yen1, and SLX4–SLX1. The Bloom syndrome helicase, BLM, plays key roles in preventing mitotic crossover, either by blocking the formation of HJ intermediates or by removing HJs without cleavage. Saccharomyces cerevisiae mutants that lack Sgs1 (the BLM ortholog) and either Mus81–Mms4 or Slx4–Slx1 are inviable, but mutants that lack Sgs1 and Yen1 are viable. The current view is that Yen1 serves primarily as a backup to Mus81–Mms4. Previous studies with Drosophila melanogaster showed that, as in yeast, loss of both DmBLM and MUS81 or MUS312 (the ortholog of SLX4) is lethal. We have now recovered and analyzed mutations in Drosophila Gen. As in yeast, there is some redundancy between Gen and mus81; however, in contrast to the case in yeast, GEN plays a more predominant role in responding to DNA damage than MUS81–MMS4. Furthermore, loss of DmBLM and GEN leads to lethality early in development. We present a comparison of phenotypes occurring in double mutants that lack DmBLM and either MUS81, GEN, or MUS312, including chromosome instability and deficiencies in cell proliferation. Our studies of synthetic lethality provide insights into the multiple functions of DmBLM and how various endonucleases may function when DmBLM is absent.
Historical Origins of Information Behavior Research by Reference Publication Year Spectroscopy
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2015

description: Background: Using a quantitative method named reference publication year spectroscopy (RPYS), this research tried to determine the historical roots of information behavior research. RPYS pave the way for determining the significant years and works in information behavior. Methodology: Using scientometric method, the initial data of this study, have been extracted from the Web of Science. Using RPYS software, the revised data were analyzed and visualized in Excel. Finding: The distribution of cited references in information behavior revealed three peaks within 19th century. Moreover, our analysis identified 6 peaks between 1900 to 1969 in the field of information behavior, respectively in 1948, 1954, 1957, 1960, 1965, and 1967 has occurred. Results: Based on the study findings, it seems that information behavior research has been shaped intellectually by fields such as Psychology, quantitative and qualitative methodologies, etc. Additionally, it has been influenced by some theories and theoretical works.
Cyclic dominance in evolutionary games: A review
Creators: name: Szolnoki, Attila
name: Mobilia, Mauro
name: Jiang, Luo-Luo
name: Szczesny, Bartosz
name: Rucklidge, Alastair M.
name: Perc, Matjaz
Publisher: name: arXiv
Year: 2014
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Social and Information Networks (cs.SI)
subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: Populations and Evolution (q-bio.PE)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences
subject: FOS: Biological sciences

description: Rock is wrapped by paper, paper is cut by scissors, and scissors are crushed by rock. This simple game is popular among children and adults to decide on trivial disputes that have no obvious winner, but cyclic dominance is also at the heart of predator-prey interactions, the mating strategy of side-blotched lizards, the overgrowth of marine sessile organisms, and the competition in microbial populations. Cyclical interactions also emerge spontaneously in evolutionary games entailing volunteering, reward, punishment, and in fact are common when the competing strategies are three or more regardless of the particularities of the game. Here we review recent advances on the rock-paper-scissors and related evolutionary games, focusing in particular on pattern formation, the impact of mobility, and the spontaneous emergence of cyclic dominance. We also review mean-field and zero-dimensional rock-paper-scissors models and the application of the complex Ginzburg-Landau equation, and we highlight the importance and usefulness of statistical physics for the successful study of large-scale ecological systems. Directions for future research, related for example to dynamical effects of coevolutionary rules and invasion reversals due to multi-point interactions, are outlined as well.
description: 21 two-column pages, 16 figures; accepted for publication in Journal of the Royal Society Interface
Collocation Method using Compactly Supported Radial Basis Function for Solving Volterra's Population Model
Creators: name: Parand, Kourosh
name: Hemami, Mohammad
Publisher: name: arXiv
Year: 2015
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: In this paper, indirect collocation approach based on compactly supported radial basis function is applied for solving Volterras population model. The method reduces the solution of this problem to the solution of a system of algebraic equations. Volterras model is a non-linear integro-differential equation where the integral term represents the effect of toxin. To solve the problem, we use the well-known CSRBF: Wendland3,5. Numerical results and residual norm 2 show good accuracy and rate of convergence.
description: 8 pages , 1 figure. arXiv admin note: text overlap with arXiv:1008.2337
New physics effects on $Λ_b\to Λ^*_cτ\barν_τ$ decays
Creators: name: Du, Meng-Lin
name: Penalva, Neus
name: Hernández, Eliecer
name: Nieves, Juan
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We benefit from a recent lattice determination of the full set of vector, axial and tensor form factors for the $Λ_b\to Λ^*_c(2595)τ\barν_τ$ and $Λ^*_c(2625)τ\barν_τ$ semileptonic decays to study the possible role of these two reactions in lepton flavor universality violation studies. Using an effective theory approach, we analyze different observables that can be accessed through the visible kinematics of the charged particles produced in the tau decay, for which we consider the $π^-ν_τ,ρ^-ν_τ$ and $μ^-\barν_μν_τ$ channels. We compare the results obtained in the Standard Model and other schemes containing new physics (NP) interactions, with either left-handed or right-handed neutrino operators. We find a discriminating power between models similar to the one of the $Λ_b\to Λ_c$ decay, although somewhat hindered in this case by the larger errors of the $Λ_b\toΛ^*_c$ lattice form factors. Notwithstanding this, the analysis of these reactions is already able to discriminate between some of the NP scenarios and its potentiality will certainly improve when more precise form factors are available.
description: 27 latex pages, 6 figures, 1 table. Version accepted for publication in Phys. Rev. D
Marketing students' perceptions of online recorded lectures
Creators: name: Ho, Henry Wai Leong
name: Weaver, Debbi
Publisher: name: La Trobe
Year: 2023

description: Students enrolled in two on-campus marketing units were surveyed about their claimed attendance at face-to-face lectures and tutorials and their access to online recordings of the lectures. Only around 30% of students claim they attend all lectures, with tutorial attendance higher for both student cohorts. Most students claim they listen to at least eight (out of twelve) of the online recorded lectures, although there does not appear to be a correlation between accessing these recordings and actual attendance - we had expected that nonattendees would claim the highest rates of listening to the recordings. Students appear to access the recordings more for revision or translation purposes, rather than to catch up lectures they have missed.

['Australian and New Zealand Marketing Academy Conference. [23rd : 2009 : Melbourne, Australia]']
A model structure on GCat
Creators: name: Bohmann, Anna Marie
name: Mazur, Kristen
name: Osorno, Angélica M.
name: Ozornova, Viktoriya
name: Ponto, Kate
name: Yarnall, Carolyn
Publisher: name: arXiv
Year: 2013
Subjects: subject: Algebraic Topology (math.AT)
subject: Category Theory (math.CT)
subject: FOS: Mathematics
subject: 55P91 (Primary), 18G55 (Secondary)

description: We define a model structure on the category GCat of small categories with an action by a finite group G by lifting the Thomason model structure on Cat. We show there is a Quillen equivalence between GCat with this model structure and GTop with the standard model structure.
description: 12 pages. Final version. Will appear in Proceedings for WIT (Women in Topology Workshop)
Utilizing mixed methods research in analyzing Iranian researchers’ informarion search behaviour in the Web and presenting current pattern
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2015

description: Using mixed methods research design, the current study has analyzed Iranian researchers’ information searching behaviour on the Web.Then based on extracted concepts, the model of their information searching behavior was revealed. . Forty-four participants, including academic staff from universities and research centers were recruited for this study selected by purposive sampling. Data were gathered from questionnairs including ten questions and semi-structured interview. Each participant’s memos were analyzed using grounded theory methods adapted from Strauss & Corbin (1998). Results showed that the main objectives of subjects were doing a research, writing a paper, studying, doing assignments, downloading files and acquiring public information in using Web. The most important of learning about how to search and retrieve information were trial and error and get help from friends among the subjects. Information resources are identified by searching in information resources (e.g. search engines, references in papers, and search in Online database…) communications facilities & tools (e.g. contact with colleagues, seminars & workshops, social networking...), and information services (e.g. RSS, Alerting, and SDI). Also, Findings indicated that searching by search engines, reviewing references, searching in online databases, and contact with colleagues and studying last issue of the electronic journals were the most important for searching. The most important strategies were using search engines and scientific tools such as Google Scholar. In addition, utilizing from simple (Quick) search method was the most common among subjects. Using of topic, keywords, title of paper were most important of elements for retrieval information. Analysis of interview showed that there were nine stages in researchers’ information searching behaviour: topic selection, initiating search, formulating search query, information retrieval, access to information, information evaluation, information selection, information management, and stop/ continue.These stages located in greater four categories: search initiation behaviors, formulating search queries, search navigational behaviors, and information processing behaviors.The study contributes to the theoretical basis of Web search research. It also raises various questions within the context of user studies.
(:unas) unassigned
Creators: name: (:Unkn) Unknown
Publisher: name: Universita' degli Studi di Salerno
Year: 2024

description: Il libro è frutto di un dialogo fra Tarca e gli altri autori del libro, sviluppatosi nell’ambito delle attività del Laboratorio di antropologia dell’Università di Salerno “Annabella Rossi”. Esso si apre con la ripubblicazione del saggio di Tarca «“Chi di negazione ferisce…”. L’unico argomento possibile per una confutazione della verità inconfutabile» (Tarca, 2016; infra, pp. 15- 35), della cui opportunità ringraziamo la casa editrice Aracne che l’ha gentilmente autorizzata. Seguono sette scritti – l’ultimo mio, gli altri di giovani e giovanissimi studiosi formatisi nel Corso di laurea in Filosofia della stessa università di Salerno – ciascuno dei quali individua in un termine della costellazione di pensieri proposta dal saggio di apertura la possibilità di un ulteriore sviluppo, di una riformulazione che definisce ciascuna un dintorno più o meno lontano dal suo centro d’irradiazione, che è appunto il puro positivo. Il libro si conclude poi con un ampio saggio, ancora di Tarca, nel quale egli cor-risponde con estrema puntualità alle osservazioni di tutti gli scritti, accettando di integrare e talvolta riformulare la propria proposta filosofica alla loro luce. ... [estratto da Introduzione di Gabriele Pulli]
Investigating the Impact of Skill-Based Capabilities on Help Seeking Behavior of Digital Libraries Users
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2015

description: Purpose: The purpose of this research investigating the impact of skill-based capabilities on help seeking behavior of digital libraries users. Methodology: the present research was carried out using a mixed method. With using of Stratified Purposive Sampling, 39 MS and PhD students of Ferdowsi University was selected as a sample. The tools that are used for collecting and analyzing data are questionnaire, think aloud protocol and Morae software. Results: results of path analysis showed that Information literacy variable has a stronger impact on users` help seeking behavior than computer literacy variable. Results also confirmed that information and computer literacy have a reverse impact on frequency of help seeking situations and help uses. But the information literacy variable has only a reverse impact on frequency of help requests with users in this research. The results confirmed the necessity of offering computer and information literacy instructions to digital library users especially when they encounter with problems in help seeking situations. Then, some recommendations to upgrade digital libraries` help facilities with considering different users skill capabilities are submitted in the end of article.
Application of Meshfree Method Based on Compactly Supported Radial Basis Function for Solving Unsteady Isothermal Gas Through a Micro-Nano Porous Medium
Creators: name: Parand, Kourosh
name: Hemami, Mohammad
Publisher: name: arXiv
Year: 2015
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: In this paper, we have applied the Meshless method based compactly supported radial basis function collocation for obtaining the numerical solution of unsteady gas equation. The unsteady gas equation is a second order non-linear two-point boundary value ordinary differential equation on the semi-infinite domain, with a boundary condition in the infinite. The compactly supported radial basis function collocation method reduces the solution of the equation to the solution of a system of algebraic equation. also, we compare the results of this work with some results. It is found that our results agree well with those by the numerical method, which verifies the validity of the present work
description: 12 pages, 5 figures. arXiv admin note: text overlap with arXiv:1509.04322
A Meta-Analysis and Genome-Wide Association Study of Platelet Count and Mean Platelet Volume in African Americans
Creators: name: Ganesh, Santhi
name: Ziv, Elad
name: Nalls, Michael A.
name: Qayyum, Rehan
name: Singleton, Andrew B.
name: Logsdon, Benjamin A.
name: Wilson, James G.
name: Harris, Tamara B.
name: Tang, Weihong
name: Yanek, Lisa R.
name: Lettre, Guillaume
name: Snively, Beverly M.
name: Liu, Yongmei
name: Evans, Michele K.
name: Mohler, Emile R.
name: Zonderman, Alan B.
name: Kooperberg, Charles
name: Becker, Diane M.
name: Folsom, Aaron R.
name: Austin, Melissa A.
name: Reiner, Alexander P.
name: Becker, Lewis C.
name: Lange, Leslie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Several genetic variants associated with platelet count and mean platelet volume (MPV) were recently reported in people of European ancestry. In this meta-analysis of 7 genome-wide association studies (GWAS) enrolling African Americans, our aim was to identify novel genetic variants associated with platelet count and MPV. For all cohorts, GWAS analysis was performed using additive models after adjusting for age, sex, and population stratification. For both platelet phenotypes, meta-analyses were conducted using inverse-variance weighted fixed-effect models. Platelet aggregation assays in whole blood were performed in the participants of the GeneSTAR cohort. Genetic variants in ten independent regions were associated with platelet count (N = 16,388) with p<5×10−8 of which 5 have not been associated with platelet count in previous GWAS. The novel genetic variants associated with platelet count were in the following regions (the most significant SNP, closest gene, and p-value): 6p22 (rs12526480, LRRC16A, p = 9.1×10−9), 7q11 (rs13236689, CD36, p = 2.8×10−9), 10q21 (rs7896518, JMJD1C, p = 2.3×10−12), 11q13 (rs477895, BAD, p = 4.9×10−8), and 20q13 (rs151361, SLMO2, p = 9.4×10−9). Three of these loci (10q21, 11q13, and 20q13) were replicated in European Americans (N = 14,909) and one (11q13) in Hispanic Americans (N = 3,462). For MPV (N = 4,531), genetic variants in 3 regions were significant at p<5×10−8, two of which were also associated with platelet count. Previously reported regions that were also significant in this study were 6p21, 6q23, 7q22, 12q24, and 19p13 for platelet count and 7q22, 17q11, and 19p13 for MPV. The most significant SNP in 1 region was also associated with ADP-induced maximal platelet aggregation in whole blood (12q24). Thus through a meta-analysis of GWAS enrolling African Americans, we have identified 5 novel regions associated with platelet count of which 3 were replicated in other ethnic groups. In addition, we also found one region associated with platelet aggregation that may play a potential role in atherothrombosis.
Hydrochus piroei Makhan 1992
Creators: name: Perkins, Philip D.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Hydrochidae
Hydrochus
Hydrochus piroei

description: Hydrochus piroei Makhan
Fig. 33
Hydrochus piroei Makhan, 1992: 97.
Originally described from Suriname, and recently reported from Venezuela (Perkins, 2019c) and Ecuador (Perkins, 2020b), the following specimen records are from Panama. Images of the habitus and male genitalia, and detailed description of the male genitalia of a specimen from Venezuela are given in Perkins (2019c).
Material examined (13): Panama: Barro Colorado Island, 24.v.1964, leg. WD & SS Duckworth (1 NMNH); Trinidad River, 21.v.1911, leg. August Busck (1 NMNH); Canal Zone, Barro Colorado Island, 5.vi.1977, leg. Nivel (1 NMNH); Panama, Tocumen, 16-19.vi.1970, leg. Diego Navas (2 NMNH); same locality, 13-17.vii.1970, leg. Diego Navas (1 CNC); same locality, 7-11.ix.1970, leg. Diego Navas (7 NMNH).
Remarks. I have examined the holotype, including the male genitalia, of H. piroei.
description: Published as part of Perkins, Philip D., 2021, Taxonomy of Central American water beetles in the genus Hydrochus Leach, 1817 (Coleoptera: Hydrochidae), pp. 459-503 in Zootaxa 4974 (3) on page 478, DOI: 10.11646/zootaxa.4974.3.2, http://zenodo.org/record/4777839
Electronic Structures of CeM2Al10 (M = Fe, Ru, and Os) Studied by Soft X-ray Resonant and High-Resolution Photoemission Spectroscopies
Creators: name: Ishiga, Toshihiko
name: Wakita, Takanori
name: Yoshida, Rikiya
name: Okazaki, Hiroyuki
name: Tsubota, Koji
name: Sunagawa, Masanori
name: Uenaka, Kanta
name: Okada, Kozo
name: Kumigashira, Hiroshi
name: Oshima, Masaharu
name: Yutani, Keisuke
name: Muro, Yuji
name: Takabatake, Toshiro
name: Muraoka, Yuji
name: Yokoya, Takayoshi
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We have performed a photoemission spectroscopy (PES) study of CeM2Al10 (M = Fe, Ru, and Os) to directly observe the electronic structure involved in the unusual magnetic ordering. Soft X-ray resonant (SXR) PES provides spectroscopic evidence of the hybridization between conduction and Ce 4f electrons (c-f hybridization) and the order of the hybridization strength (Ru < Os < Fe). High-resolution (HR) PES of CeRu2Al10 and CeOs2Al10, as compared with that of CeFe2Al10, identifies two structures that can be ascribed to structures induced by the c-f hybridization and the antiferromagnetic ordering, respectively. Although the c-f hybridization-induced structure is a depletion of the spectral intensity (pseudogap) around the Fermi level (EF) with an energy scale of 20-30 meV, the structure related to the antiferromagnetic ordering is observed as a shoulder at approximately 10-11 meV within the pseudogap. The energies of the shoulder structures of CeRu2Al10 and CeOs2Al10 are approximately half of the optical gap (20 meV), indicating that EF is located at the midpoint of the gap.
description: 17 pages, 3 figures, accepted for publication in J. Phys. Soc. Jpn
A Regulatory Network for Coordinated Flower Maturation
Creators: name: Farmer, Edward E.
name: Haupt, Ina
name: Ellis, Christine M.
name: Reed, Jason W.
name: Tholl, Dorothea
name: Nagpal, Punita
name: Reeves, Paul H.
name: Kennerley, Brian J.
name: Wu, Miin-Feng
name: Ploense, Sara E.
name: Yadav, Vandana
name: Hodgens, Charles
name: Chételat, Aurore
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: For self-pollinating plants to reproduce, male and female organ development must be coordinated as flowers mature. The Arabidopsis transcription factors AUXIN RESPONSE FACTOR 6 (ARF6) and ARF8 regulate this complex process by promoting petal expansion, stamen filament elongation, anther dehiscence, and gynoecium maturation, thereby ensuring that pollen released from the anthers is deposited on the stigma of a receptive gynoecium. ARF6 and ARF8 induce jasmonate production, which in turn triggers expression of MYB21 and MYB24, encoding R2R3 MYB transcription factors that promote petal and stamen growth. To understand the dynamics of this flower maturation regulatory network, we have characterized morphological, chemical, and global gene expression phenotypes of arf, myb, and jasmonate pathway mutant flowers. We found that MYB21 and MYB24 promoted not only petal and stamen development but also gynoecium growth. As well as regulating reproductive competence, both the ARF and MYB factors promoted nectary development or function and volatile sesquiterpene production, which may attract insect pollinators and/or repel pathogens. Mutants lacking jasmonate synthesis or response had decreased MYB21 expression and stamen and petal growth at the stage when flowers normally open, but had increased MYB21 expression in petals of older flowers, resulting in renewed and persistent petal expansion at later stages. Both auxin response and jasmonate synthesis promoted positive feedbacks that may ensure rapid petal and stamen growth as flowers open. MYB21 also fed back negatively on expression of jasmonate biosynthesis pathway genes to decrease flower jasmonate level, which correlated with termination of growth after flowers have opened. These dynamic feedbacks may promote timely, coordinated, and transient growth of flower organs.
Ultrasonic investigations of spin-ices Dy$_2$Ti$_2$O$_7$ and Ho$_2$Ti$_2$O$_7$ in and out of equilibrium
Creators: name: Erfanifam, S.
name: Zherlitsyn, S.
name: Yasin, S.
name: Skourski, Y.
name: Wosnitza, J.
name: Zvyagin, A. A.
name: McClarty, P.
name: Moessner, R.
name: Balakrishnan, G.
name: Petrenko, O. A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We report ultrasound studies of spin-lattice and single-ion effects in the spin-ice materials Dy$_2$Ti$_2$O$_7$ (DTO) and Ho$_2$Ti$_2$O$_7$ (HTO) across a broad field range up to 60 T, covering phase transformations, interactions with low-energy magnetic excitations, as well as single-ion effects. In particular, a sharp dip observed in the sound attenuation in DTO at the gas-liquid transition of the magnetic monopoles is explained based on an approach involving negative relaxation processes. Furthermore, quasi-periodic peaks in the acoustic properties of DTO due to non-equilibrium processes are found to be strongly affected by {\em macroscopic} thermal-coupling conditions: the thermal runaway observed in previous studies in DTO can be suppressed altogether by immersing the sample in liquid helium. Crystal-electric-field effects having higher energy scale lead to a renormalization of the sound velocity and sound attenuation at very high magnetic fields. We analyze our observations using an approach based on an analysis of exchange-striction couplings and single-ion effects.
Ccdc94 Protects Cells from Ionizing Radiation by Inhibiting the Expression of p53
Creators: name: Zon, Leonard I.
name: Milash, Brett
name: Harrington, Erik
name: Jette, Cicely
name: Pyati, Ujwal
name: Sorrells, Shelly
name: Hast, Bridgid
name: Carbonneau, Seth
name: Look, A. Thomas
name: Stewart, Rodney A.
name: Major, Michael B.
name: Zhou, Yi
name: Chen, Aye T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: DNA double-strand breaks (DSBs) represent one of the most deleterious forms of DNA damage to a cell. In cancer therapy, induction of cell death by DNA DSBs by ionizing radiation (IR) and certain chemotherapies is thought to mediate the successful elimination of cancer cells. However, cancer cells often evolve to evade the cytotoxicity induced by DNA DSBs, thereby forming the basis for treatment resistance. As such, a better understanding of the DSB DNA damage response (DSB–DDR) pathway will facilitate the design of more effective strategies to overcome chemo- and radioresistance. To identify novel mechanisms that protect cells from the cytotoxic effects of DNA DSBs, we performed a forward genetic screen in zebrafish for recessive mutations that enhance the IR–induced apoptotic response. Here, we describe radiosensitizing mutation 7 (rs7), which causes a severe sensitivity of zebrafish embryonic neurons to IR–induced apoptosis and is required for the proper development of the central nervous system. The rs7 mutation disrupts the coding sequence of ccdc94, a highly conserved gene that has no previous links to the DSB–DDR pathway. We demonstrate that Ccdc94 is a functional member of the Prp19 complex and that genetic knockdown of core members of this complex causes increased sensitivity to IR–induced apoptosis. We further show that Ccdc94 and the Prp19 complex protect cells from IR–induced apoptosis by repressing the expression of p53 mRNA. In summary, we have identified a new gene regulating a dosage-sensitive response to DNA DSBs during embryonic development. Future studies in human cancer cells will determine whether pharmacological inactivation of CCDC94 reduces the threshold of the cancer cell apoptotic response.
An on-chip low power low phase noise VCO with frequency divider for low jitter low phase noise applications
Creators: name: Shah, Kriyang
name: Le, Hai P
name: Singh, Jugdutt
name: Moghe, Yashodham
name: Brawley, Andrew
Publisher: name: La Trobe
Year: 2023

description: European Conference on Circuits and Systems for Communications (5th : 2010 : Belgrade, Serbia)
Checkpoints in a Yeast Differentiation Pathway Coordinate Signaling during Hyperosmotic Stress
Creators: name: Nagiec, Michal J.
name: Dohlman, Henrik G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: All eukaryotes have the ability to detect and respond to environmental and hormonal signals. In many cases these signals evoke cellular changes that are incompatible and must therefore be orchestrated by the responding cell. In the yeast Saccharomyces cerevisiae, hyperosmotic stress and mating pheromones initiate signaling cascades that each terminate with a MAP kinase, Hog1 and Fus3, respectively. Despite sharing components, these pathways are initiated by distinct inputs and produce distinct cellular behaviors. To understand how these responses are coordinated, we monitored the pheromone response during hyperosmotic conditions. We show that hyperosmotic stress limits pheromone signaling in at least three ways. First, stress delays the expression of pheromone-induced genes. Second, stress promotes the phosphorylation of a protein kinase, Rck2, and thereby inhibits pheromone-induced protein translation. Third, stress promotes the phosphorylation of a shared pathway component, Ste50, and thereby dampens pheromone-induced MAPK activation. Whereas all three mechanisms are dependent on an increase in osmolarity, only the phosphorylation events require Hog1. These findings reveal how an environmental stress signal is able to postpone responsiveness to a competing differentiation signal, by acting on multiple pathway components, in a coordinated manner.
Geometric Hydrodynamics via Madelung Transform
Creators: name: Khesin, Boris
name: Misiolek, Gerard
name: Modin, Klas
Publisher: name: arXiv
Year: 2017
Subjects: subject: Differential Geometry (math.DG)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We introduce a geometric framework to study Newton's equations on infinite-dimensional configuration spaces of diffeomorphisms and smooth probability densities. It turns out that several important PDEs of hydrodynamical origin can be described in this framework in a natural way. In particular, the Madelung transform between the Schrödinger equation and Newton's equations is a symplectomorphism of the corresponding phase spaces. Furthermore, the Madelung transform turns out to be a Kähler map when the space of densities is equipped with the Fisher-Rao information metric. We describe several dynamical applications of these results.
description: 17 pages, 2 figures