cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Impact of Sugar-Sweetened Beverage Consumption on the Liver: A Proteomics-Based Analysis
Creators: name: Benade, Janina
name: Sher, Lucien
name: De Klerk, Sheneez
name: Deshpande, Gaurang
name: Bester, Dirk
name: Marnewick, Jeanine L.
name: Sieck, Gary
name: Laher, Ismail
name: Essop, M. Faadiel
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2020

description: Cardiometabolic complications such as the metabolic syndrome and Type 2 Diabetes Mellitus (T2DM) are major causes of global morbidity and mortality. As sugar-sweetened beverages (SSBs) are implicated in this process, this study aimed to obtain greater mechanistic insights. Male Wistar rats (~200 g) were gavaged with a local SSB every day for a period of six months while the control group was gavaged with an iso-volumetric amount of water. Experimental dosages were calculated according to the surface area-to-volume ratio and were equivalent to 125 mL/day (in human terms). A proteomic analysis was performed on isolated liver samples and thereafter, markers of endoplasmic reticulum (ER) stress, antioxidant/oxidant capacity, calcium regulation, and mitochondrial functionality were assessed. These data show that SSB consumption resulted in (a) the induction of mild hepatic ER stress; (b) altered hepatic mitochondrial dynamics; and (c) perturbed calcium handling across mitochondria-associated ER membranes. Despite significant changes in markers of ER stress, the antioxidant response and calcium handling (proteomics data), the liver is able to initiate adaptive responses to counteract such stressors. However, the mitochondrial data showed increased fission and decreased fusion that may put the organism at risk for developing insulin resistance and T2DM in the longer term.
Supplementary document for Polarized imaging interpreter for simultaneous clocking metrology of multiple objects - 5382673.pdf
Creators: name: Joo, Ki-Nam
name: Bin Jeong, Hyo
name: Park, Jong-Kyu
name: Kim, Daewook
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Image Processing

description: Periodic errors and resolution tests
Representation of corporate persons: Marsilius of Padua and contemporary political theory.
Creators: name: Mongeau, Gilles.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Philosophy.

description: The thesis which follows is concerned with developing a new approach to political theory as it is practiced in the Anglo-American tradition. This tradition has been characterized by certain assumptions regarding the foundations of political theory, the most important of which has been the primacy accorded to the individual and to the political rights which develop to protect this primacy. Recent political experience in the West presents a strong challenge to the individualist stance. The rise of political interest groups, which serves as the empirical starting point for this thesis, has brought out the shortcomings of our democratic theory into the open. Various critiques, from a feminist, Marxian, ecological or other point of view, have shown how the individualism of our tradition has reached certain limits. These also show the need for a new development in political thought. The thesis is divided into two parts. The first part is diagnostic in nature: it seeks to isolate a specific question to be asked, a heuristic notion of representation that can serve as a template for further inquiry. This first part is made up of two chapters. The first chapter looks at representation from the point of view of the representative. The second chapter turns to the interests of the represented. In the second part, which is made up of three chapters, the work of Marsilius of Padua is studied to try to glean a possible solution to the heuristic notion developed earlier. Marsilius' understanding of politics is founded on a corporate notion of the individual, which is why his work is of interest. The chapters develop, in order, Marsilius' historical context, some key notions in his text, and finally some conclusions for our own theoretical enterprise. (Abstract shortened by UMI.)
title: Информационная экология
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2024

description: В учебном пособии приводятся современные данные по информационной экологии. Рассмотрены экологические термины, понятия и закономерности взаимоотношений организмов на всех уровнях организации со средой обитания. Изложены экологические проблемы, которые отражают современное состояние окружающей среды, дано представление об источниках и последствиях загрязнения окружающей среды, основных методах и средствах защиты. Издание содержит различные материалы для контроля знаний в виде домашних заданий, тестов и контрольных вопросов, которые помогут подготовиться студентам к зачету. Ситуационные задачи могут выполняться студентами как самостоятельно, так и при помощи преподавателя. Подготовлено в соответствии с Федеральным государственным образовательным стандартом высшего образования. Учебное пособие предназначено для студентов всех специальностей и направлений подготовки, учебными планами которых предусмотрено изучение дисциплины «Информационная экология».
Comprendre la pensée politique de Georges-Émile Lapalme.
Creators: name: Boies, Harold.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Political Science, General.

description: Comme son titre l'indique, cet ouvrage vise la comprehension de la pensee politique de Georges-Emile Lapalme, depute liberal federal de Joliette-L'Assomption-Montcalm de 1944 a 1950 et par la suite chef du Parti Liberal du Quebec de 1950 a 1958. En premier lieu nous etudions les effets de socialisation ayant amene Lapalme en politique active. Ceu x-ci sont les parents, l'ecole et le milieu de l'education et la profession d'avocat de campagne. Ensuite, nous decortiquons l'implicaiton de Lapalme en politique active en trois periodes distinctes: le passage au federal qui ne le marque pas mais ou il renforce ses convictions nationalistes, reformistes, sociales et culturelles qu'il peut partager et diffuser en creant le Joliette-Journal. En deuxieme lieu, l'etape de la chefferie du Parti Liberal du Quebec lui permet de mettre en application ses convictions de democrate a l'interieur de son parti et de reveler l'Etat comme phenomeme culturel. Par la suite, Georges-Emile Lapalme a l'occasion de realiser son reve: fonder le Ministere des Affaires culturelles du Quebec alors qu'il siege au pouvoir au niveau provincial pour la premiere fois. Tout le developpement etatique devait s'appuyer sur la culture, la langue francaise et le milieu de l'education. Ce n'est pas ce qui se passa et Lapalme demissionna en 1964. Cette these s'attarde a l'etude des principaux themes ci-dessus et a leurs interactions faconnant ainsi une vision tout a fait nouvelle et originale du role de l'Etat quebecois dans la modernisation de la societe quebecoise. Cet homme, Georges-Emile Lapalme, celui qui fut trop peu lu et etudie.
Supplementary document for Polarized imaging interpreter for simultaneous clocking metrology of multiple objects - 5382673.pdf
Creators: name: Joo, Ki-Nam
name: Bin Jeong, Hyo
name: Park, Jong-Kyu
name: Kim, Daewook
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Image Processing

description: Periodic errors and resolution tests
title: Экология города и безопасность жизнедеятельности человека
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2024

description: В учебнике приводятся современные данные по урбоэкологии и безопасности жизнедеятельности человека. Изложены методики решения широкого круга эколого-биологических проблем, касающихся контроля окружающей среды, техники и технологии защиты среды от промышленного загрязнения, природо- и ресурсосбережения в промышленности как формы охраны окружающей среды, а также основы безопасности жизнедеятельности. В комплексном подходе рассмотрены компоненты и система мониторинга городской среды, дистанционные и наземные средства мониторинга, источники загрязнения, вредные химико-физические воздействия на живые организмы, гигиена поверхностных вод, атмосферы и почвы, оценка воздействия на человека строительных материалов, видеоэкология, экологические требования к планировке и застройке городских поселений. Особое внимание уделено безопасности жизнедеятельности человека, в которой рассматриваются такие аспекты, как природные условия и опасные явления в окружающей среде, экология и биологические угрозы для человека, экологические опасности, безопасность в повседневной жизни, быту и на транспорте, социально опасные явления и гражданская оборона. Подготовлен с учетом требований Федерального государственного образовательного стандарта высшего образования. Учебник предназначен для студентов всех специальностей и направлений подготовки высшего образования, учебными планами которых предусмотрено изучение дисциплин «Экология города», «Экология», «Информационная экология», «Безопасность жизнедеятельности». Может представлять интерес для преподавателей и специалистов в областях урбоэкологии, инженерии и безопасности жизнедеятельности.
Supplementary document for Permutation entropy analysis of the output of a laser diode under stimulated Brillouin scattering optical feedback - 5382880.pdf
Creators: name: Rodríguez, Leidy Quintero
name: Zaldivar-Huerta, Ignacio
name: Hong, Yanhua
name: Masoller, Cristina
name: Lee, Min
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Lasers and Quantum Electronics

description: Supplementary figure
Human biomonitoring
Creators: name: (:Unkn) Unknown
Publisher: name: World Health Organization. Regional Office for Europe
Year: 2023

description: Human biomonitoring (HBM) is an instrument for measuring the internal dose of exogenous substances/chemicals that enter a body during a certain period of exposure from a range of sources. It contributes to reducing uncertainties in the assessment of health risks from chemicals and provides information for decision-making on the prevention of negative impacts of chemicals on human health and the environment. Promoting the use of HBM is a recognized priority of chemical safety globally and in the WHO European Region. Given the complexity of HBM, relevant capacities should be built at the national level to explore its benefits. This educational course on HBM, presented in the form of slides with accompanying notes and references, compiles scientific information on HBM as well as practical examples. It was developed to support the training of public-health and health-care professionals; students of medical, biological and other allied sciences; and professionals and decision-makers in the health, environment and other relevant sectors. © World Health Organization 2023
Pettit, Non-domination and Agency: A Taylorian Assessment
Creators: name: McLaughlin, Adam Bernard
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Philip Pettit
Charles Taylor
Republicanism
Non-domination
Agency
Positive Liberty
Negative Liberty

description: Philip Pettit claims his neorepublican theory of freedom as non-domination is preferable to the liberal ideal of non-interference, and he is right. But the reasons why he is right run deeper than is apparent if we attend solely to his arguments defending non-domination in negative terms. In fact, embedded in the three benefits that Pettit claims non-domination can offer (which non-interference cannot) lie significant resonances with a positive idea of freedom concerned with a person’s sense of agency. We find such an idea in Charles Taylor, where freedom as self-realization is intricately linked with his “significance view” of human agency. By adopting this Taylorian lens and assessing Pettit’s non-domination, I show that non-domination does have much to offer those of us who think of freedom primarily in positive terms and, more generally, to all those of us who believe that freedom and agency are inextricably linked and must be treated as such.
Supplementary document for Permutation entropy analysis of the output of a laser diode under stimulated Brillouin scattering optical feedback - 5382880.pdf
Creators: name: Rodríguez, Leidy Quintero
name: Zaldivar-Huerta, Ignacio
name: Hong, Yanhua
name: Masoller, Cristina
name: Lee, Min
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Lasers and Quantum Electronics

description: Supplementary figure
Perceptions of Evil: A Comparison of Moral Perspectives in Nazi Propaganda and Anti-Nazi Literature
Creators: name: Inksetter, Hamish
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Nazi
National Socialist
National Socialism
Third Reich
Hitler
Goebbels
Josef Thorak
Leni Riefenstahl
Arno Breker
Adolf Ziegler
Propaganda
Nazi art
Perspective
Morality
Worldview
Perception
Anti-Nazi
Opposition
Opponents
Dissent
Resistance
Resistenz
German
Germany 1933-1945
Clair Bergmann
Heinrich Böll
Bertolt Brecht
Hans Fallada
Lion Feuchtwanger
Ernst Jünger
Klaus Mann
Thomas Mann
Erika Mitterer
Theodor Plievier
Erich Maria Remarque
Anna Seghers
Arnold Zweig
Stefen Zweig

description: This thesis examines how the concept of evil was understood by opposing German perspectives during the era of National Socialist rule (1933-1945). The rise of Nazism in Germany marked a period of massive political upheaval wherein the National Socialist government encouraged the masses to view the world in terms of a great struggle between forces of good and evil. This was the central theme of their propaganda, which zealously encouraged racialist beliefs in the popular consciousness, and was based on assumptions of German superiority and Jewish evil. Despite Hitler's apparent success in creating an obedient nation, a significant number of Germans opposed his rule, amongst whom a small group of writers expressed their discontent through creative fiction. Through a comparison of the worldviews communicated through political propaganda and anti-Nazi literature, it is revealed that the crux of the divide between their opposing perspectives hinged on the meaning of evil. Since evil is a concept with many meanings, this thesis approaches the subject thematically. The comparison begins by focusing on the perception of evil as an all-corrupting force that had taken hold of Germany, followed by an exploration of how power and brutality were understood, ending with a comparison of views on how the struggle between good and evil took place on both a social and individual level. In addition to demonstrating the subjectivity of moral perspective during a tumultuous period of the recent past, this research reveals how the struggle against Nazism existed as a conflict of ideas. Moreover, the comparison of cultural sources (including Nazi art, visual propaganda, written texts such as Mein Kampf, and anti-Nazi creative fiction) demonstrates the value of art as a tool for conducting historical enquiry. Since the legacy of the Third Reich continues to directly influence modern perceptions of evil, exploring how evil was understood according to contemporary Germans – from both pro and anti-Nazi perspectives – is of particular historical interest.
The Influence of Follower Behaviour on Leaders' Trust in Followers
Creators: name: Bremner, Nicholas
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: followership
leadership
implicit theories
interpersonal trust
trusting beliefs
trusting intentions

description: This study reviews the burgeoning literature on followership and tests propositions from a recently developed theoretical framework to explore the relationship between follower behaviours, leaders’ perceptions of follower trustworthiness (trusting beliefs), and leaders’ subsequent willingness to be vulnerable to the actions of their followers (trusting intentions). Leaders’ implicit followership theories (IFTs) were examined as a potential moderator of both relationships. Results revealed that passive followership influenced leaders’ trusting beliefs negatively, whereas collaborative followership had a positive influence on leaders’ trusting beliefs as well as leaders’ trusting intentions. The most extreme form of proactive followership, challenging followership, had nonsignificant relationships with leaders’ trusting beliefs and intentions. In addition, leaders’ IFTs did not interact with followership behaviour to produce any change in leaders’ trusting beliefs. However, IFTs were found to moderate the relationship between leaders’ trusting beliefs and trusting intentions. Implications for research and practice are discussed in light of the results.
Supplementary document for Femtosecond laser double-pulse nanofabrication on silicon using near-field effect - 5382888.pdf
Creators: name: Hong, Quan
name: Zhang, Jin
name: Wang, Sumei
name: Chu, Zhuyuan
name: wang, mengmeng
name: Sun, Jiaxin
name: Guo, Qitong
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Fluence ablation threshold caculation model
Mollaret’ meningiit ehk korduv healoomuline lümfotsütaarne meningiit. Haigusjuhu kirjeldus
Creators: name: Unt, Triin Helin
Publisher: name: Eesti Arst
Year: 2024

description: Mollaret’ meningiit ehk Mollaret’ sündroom on harva esinev aseptilise meningiidi vorm, mida iseloomustavad korduvad meningiidiepisoodid. Tavaliselt on Mollaret’ sündroomi kliiniliseks leiuks alaäge palavik, millega kaasneb meningism ja harva ka neuroloogilised ärajäämanähud. Enamasti on selle põhjustaja lihtherpeseviiruse 2. alatüüp (HSV-2). Seljaajuvedelikus on meningiidiepisoodi ajal sagedaseks leiuks ülekaalukalt lümfotsüütaarne pleotsütoos, aga liikvorikülvi leius haiguslikke muutusi ei ilmne. Viiruslikke põhjustajaid polümeraasi ahelreaktsiooni abil tavaliselt ei leita ei liikvoris ega seerumis. Liikvorileid meningiidiepisoodide vahele jääval perioodil on tavapäraselt normaalne. Ka meningiidisümptomid paranevad iseeneslikult ilma viirusevastase ravita. Kuigi Mollaret’ meningiidi ägenemised võivad olla tõsised ja korduvad, on prognoos tavaliselt hea ja neuroloogilist defitsiiti ei jää või on seda väga harva.
description: Eesti Arst, 2024: August
Mixed-Effects Trait-State-Occasion Model: Studying the Psychometric Properties and the Person–Situation Interactions of Psychological Dynamics
Creators: name: Castro-Alvarez, Sebastian
name: Tendeiro, Jorge N.
name: de Jonge, Peter
name: Meijer, Rob R.
name: Bringmann, Laura F.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Plant Biology

description: The trait-state-occasion model (TSO) is a popular model within the latent state-trait theory (LST). The TSO allows distinguishing the trait and the state components of the psychological constructs measured in longitudinal data, while also taking into account the carry-over effects between consecutive measurements. In the present study, we extend a multilevel version of the TSO model to allow for the combination of fixed and random situations, namely the mixed-effects TSO (ME-TSO). Hence, the ME-TSO model is a measurement model suitable to analyze intensive longitudinal data that allows studying the psychometric properties of the indicators per individual, the heterogeneity of psychological dynamics, and the person–situation interaction effects. We showcase how to use the model by analyzing the items of positive affect activation of the crowdsourcing study HowNutsAreTheDutch (HoeGekisNL).
Opening up the playground: supporting library staff to learn through play
Creators: name: Reid, Helen
name: Tairi, Kim
Publisher: name: Swinburne
Year: 2024

description: Technology is the backbone of our libraries. Keeping up with the pace of change in emerging technologies is the challenge. It's time to reassess how we spread emerging technologies throughout our workplaces. The success of the 'Learning 2.0' programs around the world points to informal learning as being the way forward. Staff are increasingly being told to 'go and play' with emerging technology. This paper will explore the barriers and enablers of informal learning in libraries. It provides real-life examples of how to overcome barriers and create an environment conducive to spreading emerging technologies.
Kannabinoidide kättesaadavuse ja kasutamise suurenemise oodatav mõju reproduktiivtervisele
Creators: name: Ojaveer, Eva Liisi
name: Metsaots, Ann
name: Laanpere, Made
Publisher: name: Eesti Arst
Year: 2024

description: 2022. aastal korraldatud Eesti täiskasvanud rahvastiku tervisekäitumise uuringus selgus, et kõige sagedamini tarvitatav narkootiline aine Eestis on kanep. Kogu maailmas on suurenenud kannabinoidide (KB) tarvitamine just viljakas eas inimeste seas ning see on tingitud kanepi suurenenud kättesaadavusest, sh selle legaliseerimisest. Seetõttu on oluline teada, kuidas KBdega kokkupuude mõjutab reproduktiivtervist ja seda, kuidas võib KBde kasutamine mõjutada loodet ning lapse arengut. Artikli eesmärk on kokku võtta olemasolev tõendus KBde mõju kohta viljakas eas inimeste reproduktiivtervisele.
description: Eesti Arst, 2024: August
Designing, Implementing, Assessing, and Sustaining Sport Coach Communities of Practice
Creators: name: Bertram, Rachael Kathleen
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: social learning
value creation
coach learning
professional development

description: The purpose of this doctoral dissertation was twofold: (a) to explore how communities of practice (CoPs) can be designed, implemented, assessed, and sustained in sport settings, and (b) to examine the value that is created by participating in a community of practice using Wenger, Trayner, and De Laat’s (2011) value creation framework. Two studies were conducted. In Study One, a sport coach CoP was collaboratively designed, implemented, and assessed in a youth soccer organisation. Data generation included two individual interviews with each co-researcher, observations from CoP gatherings, and communications via an online discussion platform. Findings indicated that the co-researchers created value within each of the five cycles of value creation outlined in Wenger and colleagues’ framework. The co-researchers created value that was personally relevant to their coaching needs, which led to an increase in perceived coaching abilities. The co-researchers also gained new perspectives, such as the importance of social learning, and a broader view of athlete development. Study Two examined the value that was created in five CoPs nested in the university sport setting and how they were sustained. One interview was conducted with each participant (10 coaches and two administrators). The findings revealed that the coaches created value in each of the five cycles of the value creation framework. They learned a variety of strategies, some of which they implemented in their coaching practice. As a result, the coaches noticed an improvement in their coaching abilities and their athletes’ outcomes. The coaches also gained new perspectives, and reframed their views concerning their personal development and that of their athletes. For example, the coaches realised the importance of focusing on their own well-being. They also realised the importance of learning through social interactions, and developed a broader view of athlete development. The findings from both Study One and Study Two illustrate that CoPs in sport settings are practical and pragmatic, and that they have a positive impact on coaches’ development and on their coaching practices.
Supplementary document for Influence of the bus waveguide on the linear and nonlinear response of a taiji microresonator - 5383451.pdf
Creators: name: Franchi, Riccardo
name: Biasi, Stefano
name: de las Heras, Alberto Muñoz
name: Ghulinyan, Mher
name: Carusotto, Iacopo
name: Pavesi, Lorenzo
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental Document 1
Pseudo-labelling-aided semantic segmentation on sparsely annotated 3D point clouds
Creators: name: Yao, Yasuhiro
name: Xu, Katie
name: Murasaki, Kazuhiko
name: Ando, Shingo
name: Sagata, Atsushi
Publisher: name: Springer Berlin Heidelberg
Year: 2020

description: Manually labelling point cloud scenes for use as training data in machine learning applications is a time- and labour-intensive task. In this paper, we aim to reduce the effort associated with learning semantic segmentation tasks by introducing a semi-supervised method that operates on scenes with only a small number of labelled points. For this task, we advocate the use of pseudo-labelling in combination with PointNet, a neural network architecture for point cloud classification and segmentation. We also introduce a method for incorporating information derived from spatial relationships to aid in the pseudo-labelling process. This approach has practical advantages over current methods by working directly on point clouds and not being reliant on predefined features. Moreover, we demonstrate competitive performance on scenes from three publicly available datasets and provide studies on parameter sensitivity.
ABCA1 Increases Extracellular ATP to Mediate Cholesterol Efflux to ApoA-I
Creators: name: Lee, Jee Yeon
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: ABCA1
extracellular ATP
RAW macrophages
BHK cells
CD39
apyrase

description: ABCA1 is a key plasma membrane protein required for the efflux of cellular cholesterol to extracellular acceptors, particularly to apoA-I. This process is essential to maintain cholesterol homeostasis in the body. The detailed molecular mechanisms, however, are still insufficiently understood. Also, the molecular identity of ABCA1, i.e. channel, pump or flippase, remains unknown. In this study we analyzed the extracellular ATP levels in the medium of ABCA1-expressing BHK cells and RAW macrophages and compared them to the medium of relevant non-expressing cells. We found that the extracellular ATP concentrations are significantly elevated when cells express ABCA1. Importantly, a dysfunctional ABCA1 mutant (A937V), when expressed similarly as WT-ABCA1, is unable to raise extracellular ATP concentration. This suggests a causal relationship between functional ABCA1 and elevated extracellular ATP. To explore the physiological role of elevated extracellular ATP, we analyzed ABCA1-mediated cholesterol efflux under the conditions where extracellular ATP levels were modulated. We found that increasing extracellular ATP within the physiological range, i.e. < μM, promotes cholesterol efflux to apoA-I. On the other hand, removing extracellular ATP, either by adding apyrase to the medium or by expressing a plasma membrane bound ecto-nucleotidase CD39, abolishes cholesterol efflux to apoA-I. Based on these results we conclude that, through direct or indirect mechanisms, ABCA1 functions to raise ATP levels in the medium. This elevated extracellular ATP is required for ABCA1-mediated cholesterol efflux to apoA-I.
Investigation of the Effects of Genistein and Fenretinide on Ovarian Cancer Cells
Creators: name: Azadi, Behnam
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: Ein: Genistein
Fen: Fenretinide
SM: Soy Milk

description: The effects of the fenretinide and genistein as single or combined drugs on ovarian cancer proliferation and viability were investigated. Hypothesis: Co-treatment with genistein will enable a lower dose of fenretinide to be effective in inhibiting the proliferation and survival of ovarian cancer cells. Methods: Low and high doses of genistein and fenretinide were tested on A2780s and A2780cp cells using trypan blue viable cell count, MTS assay. Results and conclusions: Unlike low doses of fenretinide, genistein had anti-proliferative effects on both cell lines. There were no additive or synergistic effects of the two compounds. Higher dose treatments induced anti-proliferative effects and apoptotic cell death in both A2780s and A2780cp cells, with a greater sensitivity of A2780s cells to both test compounds. Overall Conclusion: Genistein and higher doses of fenretinide similarly impair cell cycle progression and induce apoptosis. The anti-proliferative effects of genistein can be affected by co-treatment with fenretinide
Südame amüloidoos – varajase diagnoosi olulisus
Creators: name: Lind, Kristin
name: Joonsalu, Tuuli
name: Pärnat, Maris
Publisher: name: Eesti Arst
Year: 2024

description: Südame amüloidoos on infiltratiivne kardiomüopaatia, mis on põhjustatud amüloidi fibrillide kuhjumisest rakuvälisesse ruumi. Tegemist on tõsise ning progresseeruva haigusega, mistõttu on prognostilises mõttes oluline selle varajane äratundmine. Hiljutised edusammud diagnostikameetodite arengus on muutnud amüloidoosi avastamise lihtsamaks, kuid näidanud ka, et haigust esineb tunduvalt sagedamini kui eelnevalt arvatud. Artiklis on käsitletud peamiselt südame amüloidoosi diagnostikat, põgusalt puudutatud ka raviprintsiipe ning kirjeldatud ühte teemakohast haigusjuhtu.
description: Eesti Arst, 2024: August
Harnessing Collective Intelligence for Translation: An Asssessment of Crowdsourcing as a Means of Bridging the Canadian Linguistic Digital Divide
Creators: name: O'Brien, Steven
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: crowdsourcing
crowd sourcing
web 2.0
translation
lwpp
digital divide
lightweight
peer-production
lightweight peer-production
Mechanical Turk
Language Professional
Non-Language Professional
Canada
linguistic
francophone
anglophone

description: This study attempts to shed light on the efficacy of crowdsourcing as a means of translating web content in Canada. Within, we seek to explore and understand if a model can be created that can estimate the effectiveness of crowdsourced translation as a means of bridging the Canadian Linguistic Digital Divide. To test our hypotheses and models, we use structural equation modeling techniques coupled with confidence intervals for comparing experimental crowdsourced translation to both professional and machine translation baselines. Furthermore, we explore a variety of factors which influence the quality of the experimental translations, how those translations performed in the context of their source text, and the ways in which the views of the quality of the experimental translations were measured before and after participants were made aware of how the experimental translations were created.
Vaade antibiootikumiresistentsusele algatuse „Üks tervis” perspektiivist
Creators: name: Allas, Ülar
name: Tenson, Tanel
Publisher: name: Eesti Arst
Year: 2024

description: Antimikroobne resistentsus (AMR) tähendab mikroobide võimet kasvada antimikroobse preparaadi juuresolekul, mis algselt oleks need mikroorganismid surmanud või nende kasvu takistanud. AMRi muudab eriti problemaatiliseks antibiootikumiresistentsuse levik. Ravimiresistentsete infektsioonide ravi nõuab kauem aega, maksab rohkem ja võib mõnikord osutuda võimatuks. Peamisteks AMRi mehhanismideks on antibiootikumi inaktiveerimine, ravimi seondumiskoha modifitseerimine, bakteriraku permeaabluse vähendamine ja ravimi rakust väljapumpamine. AMRi kujunemise ja leviku põhjusteks on paljuski antibiootikumide kasutamine põllumajandusloomade söödalisandina, samuti liig- ja väärkasutamine meditsiinis. Teisteks põhjusteks on muu hulgas kasutamata jäänud antibiootikumide väär käitlemine, reisimine, biotsiidide kasutamine ja ebapiisav hügieen. Horisontaalne geeniülekanne võimendab resistentsuse levikut, kuna võimaldab resistentsusgeenidel teistele bakteritele edasi kanduda. Suureneva AMRi riski vastu võitlemisel on otsustav tähtsus algatusel „Üks tervis“, mis hõlmab nii inim- ja veterinaarravimeid, loomapidamist, põllumajandust, kaubandust kui ka keskkonda.
description: Eesti Arst, 2024: August
Explainer: what is bipolar disorder?
Creators: name: Murray, Greg
Publisher: name: Swinburne
Year: 2024

description: During a manic episode, the main character of popular television series Homeland, CIA agent Carrie Mathison (played by Claire Danes) colour codes the evidence in a terrorism case, making vital links that could lead to a breakthrough. Creative insights such as these are relatively common among people who have bipolar disorder. In fact, our understanding of the increased creativity - and other positives - that come with bipolar disorder is driving a rethink about how people manage the negative effects of the disorder, while optimising their quality of life.
Psychological Skills of Canadian Military Pilots
Creators: name: Hohmann, Maya Danielle
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: sport psychology
aviation psychology
mental skills
Air Force
pilots
performance psychology

description: For decades, elite athletes have used mental skills training to enhance their performance. The effectiveness of these skills and strategies have been measured, documented and supported in research (e.g., Feltz & Landers, 1983; Vealey, 1994). As the remarkable benefits of mental skills continue to reach an ever-growing community of performers, it is surprising that many military organizations, known for their high standards for performance and little tolerance for error, have yet to take full advantage of this type of training. Canada’s Air Force (CAF), home to a world-renowned pilot training program, now finds itself seeking additional tools to empower pilots to achieve consistent, high quality performance under demanding, high stress conditions. The purpose of this research was to explore the psychological skills used by elite Canadian military pilots to perform successfully in this highly demanding occupation. Sixteen in-depth interviews were conducted with elite Canadian pilots at a CAF base in Saskatchewan. Results indicated that pilots utilized all seven elements of Orlick’s (2008) Wheel of Excellence over three phases of flight: pre-flight preparation, mission execution, and post-flight debriefs. Pilots also drew on elements of the Wheel of Excellence during deployments to combat zones. Effective stress management played an especially important role in this context. Recommendations for future research include mental skills usage and preparation specific to deployment contexts as well as the implementation of a specific, relevant mental skills training program within the existing CAF pilot training program
Loss of LMO4 in the Retina Leads to Reduction of GABAergic Amacrine Cells and Functional Deficits
Creators: name: Duquette, Philippe Mé
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: LMO4
retina
development
Bhlhb5

description: LMO4 is a transcription cofactor expressed during retinal development and in amacrine neurons at birth. A previous study in zebrafish reported that morpholino RNA ablation of one of two related genes, LMO4b, increases the size of the eye in embryos. However, the significance of LMO4 in mammalian eye development and function remained unknown since LMO4 null mice die prior to birth. We observed the presence of a smaller eye and/or coloboma in ~40% of LMO4 null mouse embryos. To investigate the postnatal role of LMO4 in retinal development and function, LMO4 was conditionally ablated in retinal progenitor cells using the Pax6 alpha-enhancer Cre/LMO4flox mice. We found that these mice have fewer Bhlhb5-positive GABAergic amacrine and OFF-cone bipolar cells. The deficit appears to affect the postnatal wave of Bhlhb5+ neurons, suggesting a temporal requirement for LMO4 in retinal neuron development. In contrast, cholinergic and dopaminergic amacrine, rod bipolar and photoreceptor cell numbers were not affected. The selective reduction in these interneurons was accompanied by a functional deficit revealed by electroretinography, with reduced amplitude of b-waves, indicating deficits in the inner nuclear layer of the retina. Thus, LMO4 is necessary for normal GABAergic amacrine and OFF-cone bipolar cell development during retina development.
Communicating Science: a Modern Event
Creators: name: Di Meo, Antonio
Publisher: name: Substantia
Year: 2020

description: Science is by its very nature an intersubjective, public, collaborative and democratic (at least in principle) enterprise. The modern scholar of nature, in fact, cannot but communicate first of all to his/her colleagues the results of his/her research, since, in the final analysis, science is a socially shared and socially validated corpus of knowledge. The results of research must therefore be made public but non only among the specialists. The modern way of communicating science has triggered a progressively accelerating circulation of documents (rather than researchers), reversing a more than secular trend in which scholars reached the places where knowledge was deposited and archived. The modern databases, that host books, newspaper and periodicals like actual libraries and are accessible online, represent the last expression of this inverted mobility between documents and consultants.
description: Substantia, Vol. 4 No. 2 (2020)
Mida arvavad arstitudengid laste haiglahirmust?
Creators: name: Kits, Kätlin
name: Loit, Triinu-Liis
name: Kolk, Anneli
Publisher: name: Eesti Arst
Year: 2024

description: Taust. Haiglahirm on patsientide ravisoostumust ja arstiabi kvaliteeti mõjutav kriitiline tegur kõigis vanuserühmades, eriti oluline aga laste puhul.
Eesmärk. Töö eesmärk oli uurida arstitudengite teadmisi ja hinnanguid seoses laste haiglahirmuga.
Metoodika. Uuringus osales 256 Tartu Ülikooli V kursuse arstitudengit, kes täitsid autorite koostatud 12 küsimusest koosneva esseetüüpi ankeedi. Küsimused olid struktureeritud eesmärgiga selgitada välja osalejate suhtumine ja teadmised laste haiglahirmu ning selle võimalike leevendusmeetodite kohta. Vastuste baasil koostati märksõnad, mis klasterdati edasise andmeanalüüsi tegemiseks.
Tulemused. Tulemused näitasid, et ainult 5,5% arstitudengitest ei pidanud haiglahirmu oluliseks probleemiks. 88,3% üliõpilastest arvas, et hirmuga peavad tegelema eelkõige lapsevanemad, arstide ülesandeks pidas seda 45,7% ja muu meditsiinipersonali kohustuseks 79,3%. Selgus neli olulist põhjust haiglahirmuga tegelemiseks: hirmu ennetamine tulevikus (70,3%), kvaliteetse arstiabi pakkumine (66,8%), parem koostöö (48,0%) ja stressitaseme vähendamine (39,8%). Hirmu leevendamise võimalusteks peeti protseduuri selgitamist (73,4%), nüüdisaegsete distraktsioonimeetodite kasutamist (50,0%), sõbralikku ja mängulist lähenemist (20,3%).
Järeldused. V kursuse arstitudengite teadmised laste haiglahirmu kohta olid rahuldavad, kuid nad soovisid siiski rohkem infot hirmu vähendamise konkreetsete tehnikate kohta. Haiglahirmu käsitlust ei ole praeguseni meditsiiniteaduste õppekavas, kuid arvestades uuringu tulemusi on soovitatav see teema õppekavasse lisada.
description: Eesti Arst, 2024: August
The Immune Response in Parkinson's Disease
Creators: name: Lira, Arman
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Neuroinflammation
Microgliosis
Innate immunity
Adaptive immune response
Interferon-gamma
Fc receptors
Rotenone
MPTP
Parkinson's disease

description: Microglia activity has been detected in Parkinson’s disease (PD) post-mortem brains and experimental animal models; however the precise interplay between microglia and dopamine neurons of the SNpc is not well understood. In the blood plasma of PD patients, our laboratory found elevated levels of interferon-gamma (IFN-γ), a proinflammatory cytokine and potent activator of microglia. Given this, we sought to untangle the immune responses relevant to PD in mice, examining IFN-γ’s involvement and signaling mechanism using an inflammatory co-culture model of microglia and midbrain neurons treated with rotenone. By means of RT-PCR, we discovered IFN-γ mRNA transcripts are produced by microglia, and this expression increases upon exposure to rotenone. We delineated IFN-γ’s signaling mechanism in co-cultures using different IFN-γ receptor deficient cells, and showed it engages receptors in an autocrine (not paracrine) manner to further microgliosis and dopamine cell loss. After exploring the innate immune response in a model of PD, we subsequently shifted focus to an in vivo system to better investigate any involvement of the delayed humoral arm of the adaptive immune system. Needing a time appropriate death paradigm, we developed a protracted low dose regimen of MPTP, which elicits dopaminergic cell death after 2 weeks of treatment. Subjected to this paradigm, Rag 2 mutant mice (deficient in both T and B cells) exhibit resistance to dopamine cell loss, microglia activation and motor impairments. Further evidence in support of immune involvement came with the resensitization of Rag2 mice to MPTP after reconstitution with WT splenocytes. Additionally, mice deficient in Fcγ receptors exhibited neuroprotection in our protracted degeneration model. Taken together, these data indicate the innate and humoral arm can modulate the microglial response to dopaminergic degeneration and may participate in Parkinson's disease.
Limit Values and Guideline Values in Regulatory Toxicology
Creators: name: Eckhardt, Alexander
name: Heine, Karin
Publisher: name: My University
Year: 2014

description: Depending on thematrix (e.g.,water, air) and the classification of a substance (e.g.,contaminant), a multitude of limits and guidelines has been defined. The motivationfor defining such a limit or guideline can be different. The most importantreason is to protect the population fromadverse health effects such as acute chronictoxicity or cancer. Another reason could be the protection of ecosystems whichcould be more vulnerable than humans. Moreover, aesthetic considerations, likethe taste and/or odor of drinking water, can result in limitations of chemicals. Inthe following chapter, definitions of and examples for limits in water, air, oroccupational environments are given. These lists are by no means exhaustible.© Springer-Verlag Berlin Heidelberg 2014
L'arbitrage entre la croissance et la répartition : rôle des prix et de l'utilisation de la capacité.
Creators: name: Bejaoui, Ali.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1991
Subjects: subject: Economics, Finance.

description: La presente etude examine la relation entre le taux de croissance et la repartition dans un contexte contemporain caracterise par la contractualisation des salaires nominaux. Faisant abstraction du progres technique, cette relation se reduit au lien qui pourrait exister entre le salaire reel et le taux de croissance. Pour ce faire, l'analyse s'est penchee sur cette relation dans le cadre d'un modele postkeynesien statique, ou le partage salaires-profits est subordonne au partage consommation-accumulation; le mouvement des prix (et donc du salaire reel) ou la variation du produit en assure en permanence la compatibilite. Cette analyse statique fait appel a deux developpements complementaires a savoir une theorie des prix et une theorie de l'investissement. C'est ce qui a fait l'objet de la deuxieme etape de cette analyse qui nous a permis de degager deux relations entre les prix et l'investissement, a la suite d'une divergence entre les auteurs postkeynesiens quant au role primordial assigne a l'entreprise. (Abstract shortened by UMI.)
Zooplankton Distribution and Community Structure in the Pacific and Atlantic Sectors of the Southern Ocean during Austral Summer 2017–18: A Pilot Study Conducted from Ukrainian Long-Liners
Creators: name: Pakhomov, Evgeny A.
name: Pshenichnov, Leonid K.
name: Krot, Anatoly
name: Paramonov, Valery
name: Slypko, Ilia
name: Zabroda, Pavel
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2020

description: Preliminary results of the pilot study of the zooplankton in the region between the Ross and Scotia Seas from November 2017 to April 2018 are presented. In total, 53 zooplankton samples were collected in the top 100 m water layer using vertical tows of a 0.1 m² Juday net from four Ukrainian longliners operating during the Antarctic toothfish fishery. Total zooplankton abundance ranged from 3 to 2836 ind m-³ with a global mean of 360 ± 550 (±1 SD) ind m−³. The highest abundances were recorded at the northeastern Ross Sea. At those stations, small copepods (mainly Oithona spp., Oncaea spp., Ctenocalanus spp. and copepod nauplii) numerically dominated the samples. Total biomass ranged from 0.3 to 85 mg DW m-³ with a mean of 10.9 ± 14.5 mg DW m-³. The highest biomasses were recorded at the eastern Ross Sea, where pelagic tunicates Salpa thompsoni, siphonophores and ctenophora Callianira sp. accounted for >90% of total zooplankton biomass. At other stations, zooplankton biomass generally ranged from 5 to 20 mg DW m-³ with no clear pattern in distribution. The community composition was driven by the sampling latitude and/or season rather than longitudinally. This pilot study emphasized the unique opportunity to investigate zooplankton dynamics in the regions traditionally not sampled during the oceanographic surveys. It also created unprecedented opportunities to increase the seasonal and geographical zooplankton sampling coverage using ships of opportunity at a fraction of a dedicated oceanographic survey costs. The potential of such surveys are enormous in both providing invaluable information, contributing to existing long-term databases and enhancing an international collaboration in the Southern Ocean, particularly in light of recent modeling initiatives of the whole Antarctic system undertaken by the Commission for the Conservation of Antarctic Marine Living Resources.
Deutsch-japanische Regionalkooperation - WWEC und WCPC 2016
Creators: name: Al Samarraie, Joana
name: Wetzel, Heike
name: Hübner, Katrin
Publisher: name: My University
Year: 2017
Subjects: subject: Internationale Zusammenarbeit
subject: Klimaschutz
subject: Energiewende
subject: Kommunalebene
subject: Japan
subject: Internationaler Klimaschutz
subject: Erneuerbare Energien
subject: Klima | Energie
subject: Nachhaltigkeit | Strategien | Internationales

description: In der Folge des Reaktorunfalls von Fukushima hat sich das Interesse japanischer Gemeinden, Präfekturen und Versorger an einer Umstellung auf erneuerbare Energien deutlich verstärkt. Das deutsche und das japanische Umweltministerium haben im Mai 2016 eine Vereinbarung im Bereich ⁠Klimaschutz⁠ und Energie auch durch Zusammenarbeit lokaler Regierungen getroffen. Dieser Bericht stellt die Ergebnisse einer Delegationsreise mit insgesamt 25 Vertreterinnen und Vertreter deutscher Kommunen und Regionen im November 2016 dar. Bei zahlreichen Veranstaltungen mit japanischen Kommunen und Präfekturen tauschten deutsche und japanische Teilnehmerinnen und Teilnehmer ihre Erfahrungen aus und vereinbarten die weitere Zusammenarbeit.
The Eminent French Chemist Claude-Louis Berthollet (1748-1822) in the Literature between the 19th and 21st Century
Creators: name: Sztejnberg, Aleksander
Publisher: name: Substantia
Year: 2020

description: Claude-Louis Berthollet (1748-1822) was one of the greatest French chemists of the eighteenth and the first 20 years of the nineteenth century. His life and scientific achievements were described in the literature published between the 19th and 21st centuries in different countries. The purpose of this article was to familiarize readers with the important events in the life of C.-L. Berthollet and his research activities, in particular some of his experimental research results, as well as his selected publications. In addition, the names of authors of biographies or biographical notes about Claude-Louis Berthollet, published in 1823-2018 were presented.
description: Substantia, Vol. 4 No. 2 (2020)
Fragments of an underworld
Creators: name: Lobato, Ramon
Publisher: name: Swinburne
Year: 2024

description: Two new books venture deep into the belly of global cybercrime and fraud, writes Ramon Lobato, in his review of the books 'DarkMarket: cyberthieves, cybercops and you,' by Misha Glenny, published by Random House, London, 2011, and 'The money laundry: regulating criminal finance in the global economy,' by J. C. Sharman, published by Cornell University Press, New York, 2011.