cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
XXIII Международная научно-практическая конференция «Вызовы современности и стратегии развития общества в условиях новой реальности»
Creators: name: ООО "Институт развития образования и консалтинга"
Publisher: name: ООО "Институт развития образования и консалтинга"
Year: 2024

description: XXIII Международная научно-практическая конференция «Вызовы современности и стратегии развития общества в условиях новой реальности»
Interaction of dextromethorphan hydrobromide with DNA: multispectral, voltammetric, and molecular docking technology
Creators: name: Bi, Shuyun
name: Zhou, Huifeng
name: Wu, Jun
name: Wang, Yu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Physical Sciences not elsewhere classified
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Virology

description: Interaction of dextromethorphan hydrobromide with DNA: multispectral, voltammetric, and molecular docking technology
Compounds with inhibitory activity on peristalsis from the seeds of Holarrhena antidysenterica
Creators: name: Xie, Hai-Hua
name: Su, Jian
name: Ge, Xiao-Lei
name: Dong, Ting-Ting
name: Li, Xin
name: Wen, Hui-Min
name: Sun, Bo-Hang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Virology

description: Eight compounds were isolated from the seeds of Holarrhena antidysenterica Wall.ex A.DC. On the basis of physico-chemical properties and spectroscopic data, holarrhenanan (1) was identified as a new compound, compounds 2–3 were isolated from H. antidysenterica for the first time, and five known compounds were also obtained. Inhibitory effects of some compounds and extracts to the intestinal peristalsis were evaluated. Results showed that the extracts and compounds 4, 6 exhibited remarkable inhibitory effects with tension inhibition rate of 32.77, 32.77% and amplitude inhibition rate of 59.51, 55.98%, respectively on the vitro rabbit intestinal peristalsis.
Anti-proliferative and pro-apoptotic effects of cinobufagin on human breast cancer MCF-7 cells and its molecular mechanism
Creators: name: Zhu, Ling
name: Chen, Yuxin
name: Wei, Cheng
name: Yang, Xi
name: Cheng, Jing
name: Yang, Zhimin
name: Chen, Chuanrong
name: Ji, Zhaoning
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Cinobufagin (CBF) is an active ingredient isolated from Venenum Bufonis extracted and dried from the secretory glands of Bufo gargarizans Cantor. The purpose of the study was to investigate the effects and underlying mechanisms of CBF on human breast cancer MCF-7 cells in vitro. Our results showed that CBF exhibited obvious cytotoxicity on MCF-7 cells in a dose- and time-dependent manner, as indicated by CCK-8 assays. Also, Hoechst 33258 staining and flow cytometry assays showed that CBF strongly induced MCF-7 cell apoptosis and G1 phase arrest. In addition, further molecular mechanistic investigation demonstrated that cinobufagin significantly increased Bax expression, decreased Bcl-2 expression level and up-regulated the ratio of the pro-apoptosis/anti-apoptosis protein Bax/Bcl-2, which were demonstrated by RT-qPCR and western blot assays. Taken together, our data confirm that CBF inhibits growth and triggers apoptosis of MCF-7 cells by affecting the expression of Bax and Bcl-2 in vitro.
Photospheric silicon abundances of upper main-sequence stars derived from Si II 6347/6371 doublet lines
Creators: name: Takeda, Yoichi
Publisher: name: arXiv
Year: 2021
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Silicon abundances were determined by applying the spectrum-fitting technic to the Si II doublet lines at 6347 and 6371A for a sample of 120 main-sequence stars in the T_eff range of ~7000-14000K (comprising not only normal stars but also non-magnetic chemically peculiar stars) with an aim of investigating their behaviors (e.g., correlation with stellar parameters and abundances of other elements such as Fe or C) and the background physical mechanisms involved therein, where attention was paid to taking into account of the non-LTE effect and to assigning a reasonable value of microturbulence. The following trends were revealed from the analysis: (i) The resulting [Si/H] values, mostly ranging from ~-0.5 to ~+0.3, show a positive correlation with [Fe/H]. (ii) A kind of anti-correlation exists between Si and C as seen from the tendency of [C/Si] steeply decreasing with [Si/H]. (iii) Si abundances do not show any clear dependence upon T_eff or vsini, while Am and HgMn stars appear to show comparatively higher [Si/H] than normal stars. Although it is not straightforward to explain these observational facts, different physical processes (gas-dust separation and atomic diffusion) are likely to be intricately involved in producing these characteristic behaviors of Si composition in the surface of late A through late B dwarfs.
description: Erratum newly appended in pages 23-24; originally published in Contributions of Astronomical Observatory Skalnate Pleso 52, 5-31 (2022)
Data Management plan of the Open Science Project of team Atreides for the Open Science course 2023-2024
Creators: name: Andreose, Erica
name: Di Marzo, Salvatore
name: Zilli, Leonardo
Publisher: name: Zenodo
Year: 2024

description: Data Management plan for the Open Science project of Team Atreides for the Open Science course of the University of Bologna A.y. 2023-2024.
Ganoderin A, a novel 9,11-secosterol from Ganoderma lucidum spores oil
Creators: name: Ge, Fa-Huan
name: Duan, Ming-Hui
name: Li, Jing
name: Shi, Qing-Long
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: In this study, four sterols were isolated from the Ganoderma lucidum spores oil obtained via supercritical CO2 extraction. Four chemical constituents were ganoderin A (1), chaxine B (2), ergosterol, (3) and stellasterol (4). All the separated ingredients were characterized using spectral data interpretation and by comparing with reported data. Noticeably, stellasterol and chaxine B were both firstly isolated from Ganoderma lucidum spores oil and ganoderin A was shown to bear an unprecedented skeleton.
title: Mathieu Brancourt, Jacques Leibowitch, "Le "rêve d’ICCARRE" à l’étude"
Creators: name: Brancourt, Mathieu
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Article publié sur le site Seronet et commenté par Jacques Leibowitch.
description: Source: http://www.calames.abes.fr/pub/ms/Calames-20193111232830354
description: created: start=2010;end=2017
A new iridoid glycoside from the fruits of Vitex rotundifolia
Creators: name: Zhao, Yuan-Yu
name: Guo, Lian
name: Cao, Lan-Jie
name: Zhang, Jian
name: Yin, Zhi-Qi
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: One new iridoid glycoside, 6′,10-di-O-(4-hydroxybenzoyl) aucubin (1), together with ten known compounds, including five diterpenoids (2-6), two triterpene glucosides (7-8) and three methoxylated flavonoids (9-11) were isolated from the fruits of Vitex rotundifolia. Compounds (3, 4, 7, and 8) were reported for the first time from this plant. Their structures were elucidated by spectral analysis and by comparison with literature data. Furthermore, some of the isolated compounds were evaluated for their cytotoxicities against A549 and HepG-2 cell lines using MTT assay, and only compounds 9 and 10 exhibited potent cytotoxic activity with IC50 values of 13 ± 4 and 35 ± 10 μM against HepG-2 cell lines.
New phenolic acids from Salvia yunnanensis C.H.Wright
Creators: name: Yu, Yun
name: Wang, Yin-ru
name: Dong, Zhen-huan
name: Li, Wei
name: Li, Shu-Ming
name: Huang, Xue-feng
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: Two new phenolic acids, ethyl pro-lithospermate (1), n-butyl pro-lithospermate (2) were isolated from Salvia yunnanensis C.H.Wright, along with nineteen known compounds (3–21). The structures of the isolated compounds were elucidated on the basis of extensive spectrometry and by comparing their physical and spectroscopic data to the literature. Among them, compounds 11, 12 and 14–16 were firstly isolated from S. yunnanensis C.H.Wright. Some of the isolated compounds were evaluated for their neuroprotection. Compounds 10–12 showed significant neuroprotective effects in PC12 cells and compounds 1, 4–7 displayed moderate neuroprotective effects.
Synthesis and antitumour activity of arctigenin amino acid ester derivatives against H22 hepatocellular carcinoma
Creators: name: Cai, Enbo
name: Guo, Shijie
name: Yang, Limin
name: Han, Mei
name: Xia, Jing
name: Zhao, Yan
name: Gao, Xiaorui
name: Wang, Yu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: Biochemistry
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: Arctigenin (ARG) is famous in its abundant pharmacological activity. However, many researches in it entered the bottleneck period because of its poor water solubility. The derivatives of ARG have been synthesised with five amino acids which have t-Butyloxy carbonyl (BOC) as a protective group. We examined the effects of removing BOC. The results showed that the amino acid derivatives without protective group have better water solubility and nitrite-clearing ability than ARG. Based on these results, ARG6′ and ARG9′ were selected at a dosage of 40 mg/kg to evaluate their antitumour activity. The percentage inhibition rate of ARG6′ and ARG9′ were 55.87 and 51.40, respectively, which was twice as much as ARG. Furthermore, they could increase liver and kidney indexes and produce less damage in these organs. In brief, this study provides a basis for new drug development.
Two-stage influences of hydrothermal fluids on pumice near the Iheya North hydrothermal field, Okinawa Trough
Creators: name: Zhang, Yuxiang
name: Zeng, Zhigang
name: Qi, Haiyan
name: Yin, Xuebo
name: Li, He
name: Wang, Xiaoyuan
name: Chen, Shuai
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Astronomical and Space Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Hydrothermal precipitates and hydrothermal alteration products could record important information about temporal variations of seafloor hydrothermal systems. Geochemistry, mineralogy, and microscopic features of three pumice samples (T3-1, T3-2, and T3-3) near the Iheya North hydrothermal field were analyzed in this article. The results show that T3-3 sample has undergone at least two-stage influences by hydrothermal fluids. In the first stage, pure amorphous silica from hydrothermal fluid precipitated in the vesicles of all three T3 samples as a result of conductive cooling and fluid–seawater mixing. The precipitation temperatures according to oxygen isotope thermometer are approximately 13–21°C. In the second stage, T3-3 pumice underwent low-temperature hydrothermal alteration, during which the amorphous silica precipitates were redissolved, together resulting in losses of FeO and SiO2 and gains of MgO, Pb, Zn, and Cu. Furthermore, ferruginous filamentous silica, which might be related to activities of Fe-oxidizing bacteria, was formed in the altered pumice. The transformation from pure amorphous silica precipitation to redissolution of the silica in T3-3 pumice might indicate a rise of temperature and/or decrease in silica concentrations in hydrothermal fluids, implying a changing hydrothermal environment.
Two-stage Influences of Hydrothermal Fluids on Pumice Near the Iheya North Hydrothermal Field, Okinawa Trough
Creators: name: Zhang, Yuxiang
name: Zeng, Zhigang
name: Qi, Haiyan
name: Yin, Xuebo
name: Li, He
name: Wang, Xiaoyuan
name: Chen, Shuai
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Astronomical and Space Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Hydrothermal precipitates and hydrothermal alteration products could record important information about temporal variations of seafloor hydrothermal systems. Geochemistry, mineralogy, and microscopic features of three pumice samples (T3-1, T3-2, and T3-3) near the Iheya North hydrothermal field were analyzed in this article. Results show that T3-3 sample has undergone at least two-stage influences by hydrothermal fluids. In the first stage, pure amorphous silica from hydrothermal fluid precipitated in the vesicles of all three T3 samples as results of conductive cooling and fluid-seawater mixing. The precipitation temperatures according to oxygen isotope thermometer are approximately 13–21°C. In the second stage, T3-3 pumice underwent low-temperature hydrothermal alteration, during which the amorphous silica precipitates were redissolved, together resulting in losses of FeO and SiO2 and gains of MgO, Pb, Zn, and Cu. Furthermore, ferruginous filamentous silica, which might be related to activities of Fe-oxidizing bacteria, was formed in the altered pumice. The transformation from pure amorphous silica precipitation to redissolution of the silica in T3-3 pumice might indicate a rise of temperature and/or decrease of silica concentrations in hydrothermal fluids, implying a changing hydrothermal environment.
Protective effects of traditional Chinese herbal formula Compound Xueshuantong Capsule (CXC) on rats with blood circulation disorders
Creators: name: Liu, Hong
name: Zhang, Wei-jian
name: Long, Chao-feng
name: Su, Wei-wei
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Hematology

description: Compound Xueshuantong Capsule (CXC) is a traditional Chinese herbal formula composed of root of Panax pseudoginseng var. notoginseng (Burkill) G. Hoo & C.L. Tseng, root of Astragalus membranaceus var. mongholicus (Bunge) P.K. Hsiao, root of Salvia miltiorrhiza var. charbonnelii (H. Lév.) C.Y. Wu, and root of Scrophularia ningpoensis Hemsl. CXC was approved by the China Food and Drug Administration in 2003 (No. Z20030017) based on the positive clinical effect in the treatment of cardiovascular diseases. The present study was designed to elucidate the mode of action of CXC in the regulation of the haemorheology, blood coagulation, oxidative stress and energy metabolism. Rats were placed in ice-cold water (0–4 °C) for 5 min during the time interval (4 h) between two adrenaline injections to induce blood circulation disorders. Blood was collected from abdominal aorta to detect whole blood viscosity, plasma viscosity, maximum platelet aggregation rate, erythrocyte aggregation index, red corpuscle electrophoresis index, activated partial thromboplastin time and prothrombin time. Myocardial tissue was homogenized to detect total antioxidant capacity, myeloperoxidase, Na+–K+ ATPase, and Ca2+ ATPase. The results indicated that, in addition to preventing haemorheological disorders, CXC could perform anti-platelet and anticoagulant effects, promote total antioxidant capacity and regulate myocardial energy metabolism, which might partly account for its mechanisms of action against cardiovascular diseases.
Theoretical evaluation of hydrogen on the elastic properties of cementite
Creators: name: Bombac, David
name: Stopher, Miles Alexander
name: Rivera, Pedro
Publisher: name: figshare
Year: 2019
Subjects: subject: 30304 Physical Chemistry of Materials
subject: FOS: Chemical sciences
subject: 91207 Metals and Alloy Materials
subject: FOS: Materials engineering
subject: 30307 Theory and Design of Materials

description: Hydrogen embrittlement of bearing steel is very important phenomena which severely shortens life span of bearings. In bearings especially important is rolling contact fatigue, which is significantly reduced in presence of hydrogen. Here we first demonstrate effects of hydrogen on elastic properties of cementite using density functional theory and analyse obtained elastic tensor components for stability.
Choosing a reliability inspection plan for interval censored data
Creators: name: Lu, Lu
name: Anderson-Cook, Christine M.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Science Policy

description: Reliability test plans are important for producing precise and accurate assessment of reliability characteristics. This article explores different strategies for choosing between possible inspection plans for interval-censored data given a fixed testing timeframe and budget. A new general cost structure is proposed for guiding precise quantification of total cost in inspection test plan. Multiple summaries of reliability are considered and compared as the criteria for choosing the best plans using an easily adaptable method. Different cost structures and representative true underlying reliability curves demonstrate how to assess different strategies given the logistical constraints and nature of the problem. Results show several general patterns exist across a wide variety of scenarios. Given the fixed total cost, plans that inspect more units with less frequency based on equally spaced time points are favored due to the ease of implementation and consistent good performance across a large number of case study scenarios. Plans with inspection times chosen based on equally spaced probabilities offer improved reliability estimates for the shape of the distribution, mean lifetime, and failure time for a small fraction of population only for applications with high infant mortality rates. This article uses a Monte Carlo simulation-based approach in addition to the commonly used approach based on the asymptotic variance and offers comparison and recommendation for different applications with different objectives. In addition, the article outlines a variety of different reliability metrics to use as criteria for optimization, presents a general method for evaluating different alternatives, as well as provides case study results for different common scenarios.
Choosing a Reliability Inspection Plan for Interval Censored Data
Creators: name: Lu, Lu
name: Anderson-Cook, Christine M.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Science Policy

description: Reliability test plans are important for producing precise and accurate assessment of reliability characteristics. This paper explores different strategies for choosing between possible inspection plans for interval censored data given a fixed testing timeframe and budget. A new general cost structure is proposed for guiding precise quantification of total cost in inspection test plan. Multiple summaries of reliability are considered and compared as the criteria for choosing the best plans using an easily adapted method. Different cost structures and representative true underlying reliability curves demonstrate how to assess different strategies given the logistical constraints and nature of the problem. Results show several general patterns exist across a wide variety of scenarios. Given the fixed total cost, plans that inspect more units with less frequency based on equally spaced time points are favored due to the ease of implementation and consistent good performance across a large number of case study scenarios. Plans with inspection times chosen based on equally spaced probabilities offer improved reliability estimates for the shape of the distribution, mean lifetime, and failure time for a small fraction of population only for applications with high infant mortality rates. The paper uses a Monte Carlo simulation based approach in addition to the common evaluation based on the asymptotic variance and offers comparison and recommendation for different applications with different objectives. In addition, the paper outlines a variety of different reliability metrics to use as criteria for optimization, presents a general method for evaluating different alternatives, as well as provides case study results for different common scenarios.
Linear energy transfer distributions in the brainstem depending on tumour location in intensity-modulated proton therapy of paediatric cancer
Creators: name: Fjæra, Lars Fredrik
name: Li, Zuofeng
name: S. Ytre-Hauge, Kristian
name: P. Muren, Ludvig
name: J. Indelicato, Daniel
name: Lassen-Ramshad, Yasmin
name: Engeseth, Grete May
name: Brydøy, Marianne
name: Mairani, Andrea
name: Flampouri, Stella
name: Dahl, Olav
name: H. Stokkevåg, Camilla
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Physical Sciences not elsewhere classified
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Background: For tumours near organs at risk, there is concern about unintended increase in biological dose from elevated linear energy transfer (LET) at the distal end of treatment fields. The objective of this study was therefore to investigate how different paediatric posterior fossa tumour locations impact LET and biological dose to the brainstem during intensity-modulated proton therapy (IMPT). Material and methods: Multiple IMPT plans were generated for four different simulated tumour locations relative to the brainstem for a five-year-old male patient. A prescribed dose of 59.4 Gy(RBE) was applied to the planning target volumes (PTVs). Plans with two lateral and one posterior non-coplanar fields were created, along with plans with modified field arrangements. The dose-averaged LET (LETd) and the physical dose × RBELET (D × RBELET), where RBELET=1+c × LETd, were calculated using the FLUKA Monte Carlo code. A scaling parameter c was applied to make the RBELET represent variations in the biological effect due to LET. Results: High LETd values surrounded parts of the PTV and encompassed portions of the brainstem. Mean LETd values in the brainstem were 3.2–6.6 keV/μm. The highest absolute brainstem LETd values were seen with the tumour located most distant from the brainstem, whereas lower and more homogeneous LETd values were seen when the tumour invaded the brainstem. In contrast, the highest mean D × RBELET values were found in the latter case (54.0 Gy(RBE)), while the case with largest distance between tumour and brainstem had a mean D × RBELET of 1.8 Gy(RBE). Conclusions: Using IMPT to treat posterior fossa tumours may result in high LETd values within the brainstem, particularly if the tumour volume is separated from the brainstem. However, the D × RBELET was greater for tumours that approached or invaded the brainstem. Changing field angles showed a reduction of LETd and D × RBELET in the brainstem.
title: Fiche Module CESU "InDesign"
Creators: name: LabexMed
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Formation sur InDesign, réalisée par Stéphane Renault.
Antioxidant and alpha-glucosidase inhibitory activities of isoflavonoids from the rhizomes of Ficus tikoua Bur
Creators: name: Fu, Guangmiao
name: Li, Wenjuan
name: Huang, Xiangzhong
name: Zhang, Runzhi
name: Tian, Kai
name: Hou, Shuqun
name: Li, Yukui
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: A new unique isoflavone derivatives with a cyclic-monoterpene-substituent, ficusin C (1), together with five known compounds (2–6), were isolated from the rhizomes of Ficus tikoua. Their structures were elucidated on the basis of spectroscopic data interpretation, mass spectrometric analysis and comparison with literature data of related compounds. Antioxidant and α-glucosidase inhibitory activities of these compounds were evaluated by 1,1-diphenyl-2-picryhydrazyl (DPPH) radical-scavenging assay and α-glucosidase inhibitory experiment, respectively.
Phytochemical investigations and evaluation of antimutagenic activity of the alcoholic extract of Glycosmis pentaphylla and Tabernaemontana coronaria by Ames test
Creators: name: Kumar, Ashish
name: Banerjee, Nilanjana
name: Singamaneni, Venugopal
name: Dokuparthi, Sudheer K
name: Chakrabarti, Tulika
name: Mukhopadhyay, Sibabrata
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: Chemical investigation of root bark of Glycosmis pentaphylla and stem bark of Tabernaemontana coronaria led to the isolation of three carbazole alkaloids glycozoline, glycozolidine and methyl carbazole 3-carboxylate, two furoquinoline alkaloids skimmianine and dictamine, an acridone alkaloid arborinine, three monomeric indole alkaloids coronaridine, 10-methoxy coronaridine and tabernaemontanine, and two dimeric indole alkaloids voacamine and tabernaelegantine B. Their structures were established by detailed spectral analysis. Mutagenic and antimutagenic potential of methanol extract of both plant materials were evaluated by Ames test against known positive mutagens 2-aminofluorine, 4-nitro-O-phenylenediamine and sodium azide using Salmonella typhimurium TA 98 and TA 100 bacterial strains both in the presence and absence of S9. Both the extracts were non-mutagenic in nature. Both the extracts of G. pentaphylla and T. coronaria exhibited significant antimutagenic activity against NPD and sodium azide for S. typhimurium TA98 and TA100 strains. The results indicated that the extracts could counteract the mutagenicity induced by different genotoxic compounds.
Metabolic engineering strategies for acetoin and 2,3-butanediol production: advances and prospects
Creators: name: Yang, Taowei
name: Rao, Zhiming
name: Zhang, Xian
name: Xu, Meijuan
name: Xu, Zhenghong
name: Yang, Shang-Tian
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Acetoin and 2,3-butanediol (2,3-BD) have a large number of industrial applications. The production of acetoin and 2,3-BD has traditionally relied on oil supplies. Microbial production of acetoin and 2,3-BD will alleviate the dependence on oil. Acetoin and 2,3-BD are neighboring metabolites in the 2,3-BD metabolic pathway of bacteria. This review summarizes metabolic engineering strategies for improvement of microbial acetoin and 2,3-BD production. We also propose enhancements to current acetoin and 2,3-BD production strategies, by offering a metabolic engineering approach that is guided by systems biology and synthetic biology.
A dynamic scheduling algorithm for singe-arm two-cluster tools with flexible processing times
Creators: name: Li, Xin
name: Fung, Richard Y. K.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Science Policy

description: This article presents a dynamic algorithm for job scheduling in two-cluster tools producing multi-type wafers with flexible processing times. Flexible processing times mean that the actual times for processing wafers should be within given time intervals. The objective of the work is to minimize the completion time of the newly inserted wafer. To deal with this issue, a two-cluster tool is decomposed into three reduced single-cluster tools (RCTs) in a series based on a decomposition approach proposed in this article. For each single-cluster tool, a dynamic scheduling algorithm based on temporal constraints is developed to schedule the newly inserted wafer. Three experiments have been carried out to test the dynamic scheduling algorithm proposed, comparing with the results the ‘earliest starting time’ heuristic (EST) adopted in previous literature. The results show that the dynamic algorithm proposed in this article is effective and practical.
Novel and practical synthesis of vonoprazan fumarate
Creators: name: Yu, Qian-Ying
name: Zeng, Huang
name: Yao, Kai
name: Li, Jian-Qi
name: Liu, Yu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: Biochemistry
Medicine
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Developmental Biology
Science Policy
Computational Biology

description: A novel and practical strategy for the synthesis of vonoprazan fumarate 1, a novel potassium-competitive acid blocker, has been developed. Vonoprazan fumarate was obtained through a four-step process starting from 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate and including ester hydrolyzing, methylamine substitution, sulfonyl chloride substitution, and amide reduction. Key to the strategy is the amide reduction taking a novel and practical protocol. The main advantages of this route include two parts: controllable impurity and acceptable overall yield.
A Novel and Practical Synthesis of Vonoprazan Fumarate
Creators: name: Yu, Qian-Ying
name: Zeng, Huang
name: Yao, Kai
name: Li, Jian-Qi
name: Liu, Yu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: Biochemistry
Medicine
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Developmental Biology
Science Policy
Computational Biology

description: A novel and practical strategy for the synthesis of vonoprazan fumarate 1, a novel potassium-competitive acid blocker, has been developed. Vonoprazan fumarate was obtained via a four-step process starting from 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate and including ester hydrolyzing, methylamine substitution, sulfonyl chloride substitution and amide reduction. Key to the strategy is the amide reduction taking a novel and practical protocol. The main advantages of this route include two parts: controllable impurity and acceptable overall yield.
Figure ESM3 from Social learning and the demise of costly cooperation in humans
Creators: name: Burton-Chellew, Maxwell N.
name: Mouden, Claire El
name: West, Stuart A.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Lack of attraction to common behaviours. Shown is the average decrease in absolute difference between an individual's level of cooperation and the relevant social information; Mode: the most frequent behaviour among four individuals from another group (Other-group treatment, N = 180 observations on 48 individuals); Mode (coop): excludes cases where the mode = 0 (N = 136 observations on 48 individuals); Mean: the mean cooperation of four individuals from another group (Other-group, N = 240 observations on 48 individuals); Mean of means: the mean cooperation of three other groups (Group-means treatment, N = 240 observations on 48 individuals). A positive reduction in the absolute difference represents attraction, and a negative reduction represents aversion. Error bars are the 95% confidence intervals. In no cases is there a significant attraction towards the relevant common behaviour.
Table ESM2 from Social learning and the demise of costly cooperation in humans
Creators: name: Burton-Chellew, Maxwell N.
name: Mouden, Claire El
name: West, Stuart A.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Generalized linear mixed models (GzLMM1) investigating if contributions (0-20 MU) were correlated with the social information we provided. Treatments are broken down into their sub treatments depending on whether extra information was shown or not. Shown are the coefficient (± std. error) and Akaike Information Criterion score (AIC) for each model. Asterisks denote significance value; *P < 0.05, ** P < 0.01, *** P<0.001
Figure ESM1 from Social learning and the demise of costly cooperation in humans
Creators: name: Burton-Chellew, Maxwell N.
name: Mouden, Claire El
name: West, Stuart A.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Social learning and the demise of cooperation. Shown is the median level of cooperation (0-20 MU) per round of the game for each treatment outlined in Figure 1. Empty circles refer to when we provided no information (a, N = 288). Solid lines refer to within-group effects (b, N = 48 in each case). Dashed lines refer to social learning treatments (c-f, N = 24 in each case). Social information leads to the demise of cooperation. In all information treatments, median cooperation declines to below 3 MU (15%) by the final round, reaching 0 MU in five of the eight social learning treatments.
Curcumin sensitizes prostate cancer cells to radiation partly via epigenetic activation of miR-143 and miR-143 mediated autophagy inhibition
Creators: name: Liu, Jianbo
name: Li, Min
name: Wang, Yuewei
name: Luo, Jianchao
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Cancer

description: Curcumin has been reported as a radiosensitizer in prostate cancer. But the underlying mechanism is not well understood. In this study, we firstly assessed how curcumin affects the expression of miR-143/miR-145 cluster. Then, we investigated whether miR-143 is involved in regulation of radiosensitivity and its association with autophagy in prostate cancer cells. Our data showed that PC3, DU145 and LNCaP cells treated with curcumin had significantly restored miR-143 and miR-145 expression. Curcumin showed similar effect as 5-AZA-dC on reducing methylation of CpG dinucleotides in miR-143 promoter. In addition, curcumin treatment reduced the expression of DNMT1 and DNMT3B, which contribute to promoter hypermethylation of the miR-143/miR-145 cluster. Therefore, we infer that curcumin can restore miR-143 and miR-145 expression via hypomethylation. MiR-143 overexpression and curcumin pretreatment enhanced radiation induced cancer cell growth inhibition and apoptosis. MiR-143 and curcumin remarkably reduced radiation-induced autophagy in PC3 and DU145 cells. MiR-143 overexpression alone also reduced the basal level of autophagy in DU145 cells. Mechanistically, miR-143 can suppress autophagy in prostate cancer cells at least via downregulating ATG2B. Based on these findings, we infer that curcumin sensitizes prostate cancer cells to radiation partly via epigenetic activation of miR-143 and miR-143 mediated autophagy inhibition.
In silico modelling and molecular dynamics simulation studies of thiazolidine based PTP1B inhibitors
Creators: name: Mahapatra, Manoj Kumar
name: Bera, Krishnendu
name: Singh, Durg Vijay
name: Kumar, Rajnish
name: Kumar, Manoj
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Computational Biology

description: Protein tyrosine phosphatase 1B (PTP1B) has been identified as a negative regulator of insulin and leptin signalling pathway; hence, it can be considered as a new therapeutic target of intervention for the treatment of type 2 diabetes. Inhibition of this molecular target takes care of both diabetes and obesity, i.e. diabestiy. In order to get more information on identification and optimization of lead, pharmacophore modelling, atom-based 3D QSAR, docking and molecular dynamics studies were carried out on a set of ligands containing thiazolidine scaffold. A six-point pharmacophore model consisting of three hydrogen bond acceptor (A), one negative ionic (N) and two aromatic rings (R) with discrete geometries as pharmacophoric features were developed for a predictive 3D QSAR model. The probable binding conformation of the ligands within the active site was studied through molecular docking. The molecular interactions and the structural features responsible for PTP1B inhibition and selectivity were further supplemented by molecular dynamics simulation study for a time scale of 30 ns. The present investigation has identified some of the indispensible structural features of thiazolidine analogues which can further be explored to optimize PTP1B inhibitors.
Figure ESM4 from Social learning and the demise of costly cooperation in humans
Creators: name: Burton-Chellew, Maxwell N.
name: Mouden, Claire El
name: West, Stuart A.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Regression to the mean in public-goods games. Shown are the individual changes in cooperative contribution relative to their prior contribution, for individuals receiving no-information between periods, plotted against the individual’s prior deviation from the mean cooperation of their groupmates (filled grey circles, 1,440 observations). Dashed and dotted lines show the maximum possible increase and decrease respectively for each possible value of deviation. The bounded nature of the data constrains changes depending on deviation. The solid line shows the significant negative regression to the mean (controlling for individual, N = 288). Relatively low cooperators are significantly likely to increase their cooperation and vice versa even when they have no information about the behaviour of other players. This statistical artifact can give a false impression of players conforming to average group behaviour.
Carnet nº 4, commencé à Novorossiïsk (p. 112)
Creators: name: Péraire, Lucien
name: CNRS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023

description: created: 8-8-1929
Comparison of the structures and electronic properties of sodalites containing alkali metals and alkali-earth metals and their hydrates
Creators: name: Hou, Xin-Juan
name: Li, Huiquan
name: He, Peng
name: Li, Shaopeng
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Astronomical and Space Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Plant Biology

description: The effects of different alkali and alkali-earth metal ions on the electronic structures and properties of sodalite Mn[AlSiO4]6 (M-SOD) and their hydrates Mn[AlSiO4]6⋅8H2O (M=Li, Na, K, n = 6; M=Ca, n = 3) were studied using density functional theory method. Theoretical calculations predicted that the Al–O–Si bond angle and cation-framework oxide distance in sodalites with alkali metal cations are correlated with cell volumes. The reduced bandwidths in M-SOD (M=Li, Na and K) show that the inter-atomic orbital overlap in sodalites is weaker than those in the hydrate phases. Frontier molecular orbital analysis indicated that oxygen atoms in the frameworks and most metal ions of SOD and their corresponding hydrates exhibit high reactivity. The interactions existing in sodalites and hydrates were qualitative described. The calculated combination energies of metal ions with framework of sodalites are in the order of K+< Na+< Li+< Ca2+. This finding confirms the experimental observation for ion exchange.
Carnet nº 2, commencé à Vienne (p. 54)
Creators: name: Péraire, Lucien
name: CNRS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023

description: created: 26-9-1928
Table ESM1 from Social learning and the demise of costly cooperation in humans
Creators: name: Burton-Chellew, Maxwell N.
name: Mouden, Claire El
name: West, Stuart A.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Generalized linear mixed models (GzLMM1) investigating if contributions (0-20 MU) were correlated with the social information we provided. Shown are the model coefficients (± std. error) and the model Akaike Information Criterion score (AIC). Asterisks denote significance value; *P < 0.05, ** P < 0.01, *** P<0.001
IYPT Problem No. 2: Droplet Microscope
Creators: name: Tariq, Muhammad Yusuf
name: Ali, Murtaza
name: Ahmad, Muhammad
name: Faisal, Muhammad Ibraheem
name: Ijaz, Hania
Publisher: name: Zenodo
Year: 2024

description: This study explores the optical properties of a water droplet as a natural magnifying lens, focusing on its magnification and resolution capabilities. By analyzing the droplet’s shape influenced by surface tension and gravity, we approximate its form as an oblate spheroid and derive key optical parameters. The droplet functions as a thick lens, and calculations include focal length, principal planes, and hiatus distance, which impact the droplet’s ability to magnify objects. We measure linear and angular magnification and address limitations in resolution due to diffraction, Rayleigh criterion, and optical aberrations. Experimental imaging of a leaf through the droplet demonstrated measurable magnification and provides insight into using simple natural structures as functional optical systems.
Role of clays in fouling-resistant clay-embedded polyelectrolyte multilayer membranes for wastewater effluent treatment
Creators: name: Hong, Joung Sook
name: Yu, Jing
name: Lee, Ilsoon
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Astronomical and Space Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Hematology
subject: Plant Biology

description: This study aimed to investigate the effects of cation exchange capacity (CEC) and location of clay nanoplatelets on the structure and performance of clay-embedded polyelectrolyte multilayer (c-PEM) membranes for wastewater effluent treatment. Two kinds of clay nanoplatelets, montmorillonite and kaolin, were deposited on the ultrafiltration membrane by employing layer-by-layer (LbL) assembly with poly(allylamine hydrochloride) (PAH) and poly(acrylic acid) (PAA). Negatively charged clay platelets or PAA interacted with positively charged PAH to form a bilayer in the c-PEM membrane. The filtration effect of clay platelets was successively distinguished from PEM by reducing the number of (PAH/PAA) bilayers from four to one, while keeping the clay layer at the outermost layer of assembly. When the clay platelets were deposited only as the outermost layer of the LbL multilayers, the c-PEM membrane with one clay layer and one bilayer assembly showed significant flux barrier and fouling resistance. Clay platelets as the outermost layer physically increased the flow path length and decreased the number of pores, as well as effectively blocked the organic contaminants in the wastewater. Meanwhile, when the clay layer was embedded in the middle of the PEM, the synergistic effect of clay platelets and PEM for wastewater treatment was difficult to obtain because the presence of clay platelets defected the buildup of fully interdigitated c-PEM and the adsorption of clay platelets was decreased. For the clays having low CEC, a higher number of LbL multilayers were required to deposit the clay platelets and to improve the performance of membrane. The high CEC clays (montmorillonite) turned out to be better than the low CEC clays (kaolin) in the structure and performance of the c-PEM membrane for wastewater effluent treatment.
Figure ESM2 from Social learning and the demise of costly cooperation in humans
Creators: name: Burton-Chellew, Maxwell N.
name: Mouden, Claire El
name: West, Stuart A.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Attraction to highest-earning examples. Shown is the increase in average attraction towards the highest-earning example when information on concurrent payoffs was also made available for each social learning treatment, (Other-group, Group-means, Group-leaders, Overall-leaders, N = 24 in each case, Fig. 1) and all social learning treatments combined (N = 96). Postive values indicate that the average attraction to the highest-earning example was greater when payoffs were also shown; 0 indicates no difference in attraction depending on whether payoffs shown. Error bars are the 95% confidence intervals. In all treatments the effect is positive, signficantly so when all treatments are combined.