cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Synthesis, molecular docking and QSAR study of thiazole clubbed pyrazole hybrid as α-amylase inhibitor
Creators: name: Duhan, Meenakshi
name: Singh, Rahul
name: Devi, Meena
name: Sindhu, Jayant
name: Bhatia, Rimpy
name: Kumar, Ashwani
name: Kumar, Parvin
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: In search of potent α-amylase inhibitors, herein we report the synthesis, molecular docking and QSAR study of some thiazole clubbed pyrazole hybrids (TCPH) i.e., 1-((1-phenyl-3-aryl-1H-pyrazole-4-yl)methylene)-2-(4-arylthiazole-2-yl)hydrazine (4a–4r) as an α-amylase inhibitors. Among the different analogues, compounds 4g and 4h were found to be most potent at 50 µg/mL with 89.15% and 88.42% of inhibition. The Monte Carlo optimisation method was applied to build robust QSAR models for the prediction of percentage inhibition of TCPH at different concentration with various statistical parameters. The Simplified Molecular Input Line Entry System (SMILES) was applied to symbolise the molecular structure, descriptor calculation and model development. The role of the index of ideality correlation (IIC) was also studied which revealed a model for split 3 as a leading model with best R2 i.e., 0.9198. The compound 4l at different concentration (TCPH11, TCPH29 and TCPH47) was outside the applicability domain (AD) for the developed QSAR models for split 4 only. The SMILES attributes at three different concentrations were also detected. These attributes are the promoters of percentage increase/decrease in inhibition efficiency of the inhibitors. The docking simulation of most active compounds (4g and 4h) were performed within the active site of Aspergillus oryzae α-amylase (PDB ID: 7TAA) to analyse the binding conformation and interactions responsible for their activity. As a result, it was found that the binding interactions found between 4g, 4h and α-amylase were similar to those responsible for α-amylase inhibition by acarbose. Communicated by Ramaswamy H. Sarma
DeepForge: Leveraging AI for Microstructural Control in Metal Forming via Model Predictive Control
Creators: name: Petrik, Jan
name: Bambach, Markus
Publisher: name: arXiv
Year: 2024
Subjects: subject: Machine Learning (cs.LG)
subject: Systems and Control (eess.SY)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: This study presents a novel method for microstructure control in closed die hot forging that combines Model Predictive Control (MPC) with a developed machine learning model called DeepForge. DeepForge uses an architecture that combines 1D convolutional neural networks and gated recurrent units. It uses surface temperature measurements of a workpiece as input to predict microstructure changes during forging. The paper also details DeepForge's architecture and the finite element simulation model used to generate the data set, using a three-stroke forging process. The results demonstrate DeepForge's ability to predict microstructure with a mean absolute error of 0.4$\pm$0.3%. In addition, the study explores the use of MPC to adjust inter-stroke wait times, effectively counteracting temperature disturbances to achieve a target grain size of less than 35 microns within a specific 2D region of the workpiece. These results are then verified experimentally, demonstrating a significant step towards improved control and quality in forging processes where temperature can be used as an additional degree of freedom in the process.
Synthesis, molecular docking and QSAR study of thiazole clubbed pyrazole hybrid as α-amylase inhibitor
Creators: name: Duhan, Meenakshi
name: Singh, Rahul
name: Devi, Meena
name: Sindhu, Jayant
name: Bhatia, Rimpy
name: Kumar, Ashwani
name: Kumar, Parvin
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: In search of potent α-amylase inhibitors, herein we report the synthesis, molecular docking and QSAR study of some thiazole clubbed pyrazole hybrids (TCPH) i.e., 1-((1-phenyl-3-aryl-1H-pyrazole-4-yl)methylene)-2-(4-arylthiazole-2-yl)hydrazine (4a–4r) as an α-amylase inhibitors. Among the different analogues, compounds 4g and 4h were found to be most potent at 50 µg/mL with 89.15% and 88.42% of inhibition. The Monte Carlo optimisation method was applied to build robust QSAR models for the prediction of percentage inhibition of TCPH at different concentration with various statistical parameters. The Simplified Molecular Input Line Entry System (SMILES) was applied to symbolise the molecular structure, descriptor calculation and model development. The role of the index of ideality correlation (IIC) was also studied which revealed a model for split 3 as a leading model with best R2 i.e., 0.9198. The compound 4l at different concentration (TCPH11, TCPH29 and TCPH47) was outside the applicability domain (AD) for the developed QSAR models for split 4 only. The SMILES attributes at three different concentrations were also detected. These attributes are the promoters of percentage increase/decrease in inhibition efficiency of the inhibitors. The docking simulation of most active compounds (4g and 4h) were performed within the active site of Aspergillus oryzae α-amylase (PDB ID: 7TAA) to analyse the binding conformation and interactions responsible for their activity. As a result, it was found that the binding interactions found between 4g, 4h and α-amylase were similar to those responsible for α-amylase inhibition by acarbose. Communicated by Ramaswamy H. Sarma
Operacionalização e Sustentabilidade da identificação do Talento interno nas organizações
Creators: name: Caracol, Carla Cristina
name: Palma, Patrícia Jardim Da
name: Sousa, Maria José
Publisher: name: Proceedings - Research and Intervention in Human Resources
Year: 2016

description: Atualmente, devido a vários constrangimentos estruturais e contextuais, as organizações encontram-se limitadas em atrair novos trabalhadores, novo Talento, o que, face às exigências crescentes e cada vez mais mutáveis, caracterizadoras dos mercados concorrenciais em que operam, se poderá traduzir numa forte condicionante à sua sustentabilidade e sucesso. Consequentemente, importa, cada vez mais, aferir a qualidade do Capital Humano detido, de forma a otimizar o investimento habitual e permanente, identificando estrategicamente o Talento interno, de forma mais eficaz e eficiente, visando o know-how e competências necessárias, que lhes permita fazer mais e melhor com os mesmos recursos. Este propósito torna-se essencial para academias e organizações na medida em que embora o Talento seja considerado a questão organizacional crítica para o século XXI, é paradigmático que lhe falte consistência na definição e nos limites conceptuais. É, assim, nosso objetivo, nesta comunicação, auxiliar as organizações a conceberem e implementarem indicadores que lhes permitam identificar essa pool de Talento interno, de forma a conseguir retirar o melhor das suas melhores Pessoas, numa perspetiva estratégica de win-win, entre colaboradores e organização, conciliando-se expectativas e necessidades de ambos, em que os primeiros contribuem de forma positivamente diferenciadora a favor da segunda, realizando-se, simultaneamente, pessoal e profissionalmente. Partindo de uma revisão crítica de literatura intensiva e do estudo de caso de uma Universidade Corporativa, recorrendo à análise documental e entrevistas com key-persons, são apresentados instrumentos e estratégias que permitem identificar o Talento interno detido, através da sua segmentação, de acordo com o seu valor para a organização, nume perspetiva de retorno para a consecução dos intentos organizacionais.
description: Proceedings - Research and Intervention in Human Resources, n. 6 (2016): VI Conferência em Investigação e Intervenção em RH
Source data of uncropped gel and western blot and in vitro helicase assay
Creators: name: Xu, Hongzhan
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 310109
subject: Proteomics and intermolecular interactions (excl. medical proteomics)

description: Uncropped gel data, Western blot and in vitro helicase assay data
Fibre cavities for microactivity polaritons
Creators: name: Wood, Andrew
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: This thesis reports on the implementation of a CO2 laser-machining setup for making smooth concave mirror substrates at the end of optical fibres. Once coated with a highly-reflective DBR mirror (reflectivity larger than 99.9999%), the mirrors serve as one end of an open, tunable fibre coupled microcavity, so called fibre cavities. The main characteristic of the mirror substrates machined with the present setup is their very small curvature radius in the range of 8-10µm. Through systematic variation of the main laser parameters, such as pulse duration, power and position of the beam waist a large parameter range can be accessed. Beside the capability for making small mirror substrates, other key features of the setup include the high reproducibility and the large number of fibres that can be machined and analysed in parallel. An integrated interferometric setup allows for in-situ analysis of the machined fibre surfaces. In the course of this work, a first batch of 96 fibres, mainly with small curvature radii, was fabricated and sent for coating. The small curvature radii achieved with the setup are expected to be favourable for the realization of the polariton blockade effect with semiconductor quantum-well polaritons.
การจัดการความรู้ เพื่อก้าวสู่องค์กรดิจิทัลในยุคเทคโนโลยีพลิกผัน
Creators: name: นวพล แก้วสุวรรณ
name: ธัญญาลักษณ์ ใจเที่ยง
name: สิริกร บำรุงกิจ
Publisher: name: สำนักงานบริหารการวิจัย นวัตกรรมและการสร้างสรรค์
Year: 2563
Subjects: การจัดการความรู้
องค์กรดิจิทัล
เทคโนโลยีพลิกผัน

description: วารสารมหาวิทยาลัยศิลปากร, 40, 4, 120-135
Los siete dolores que pasó Maria Santísima en la sacrada pasión y muerte de su amantísimo hijo: Digital edition
Creators: name: Leblanc Elina
Publisher: name: Zenodo
Year: 2022
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2024), led by the professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
title: ADCO, Cart. 186 (11 H 71), f. 0443v
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, t. II (XVe siècle), tome II, Archives départementales de la Côte-d'Or, C
art. 186 (11 H 71). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, t. II (XVe siècle), tome II, Archives départementales de la
 Côte-d'Or, Cart. 186 (11 H 71), f. 0443v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-
project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Additional file 1: of Plasma levels of alarmin HNPs 1â 3 associate with lung dysfunction after cardiac surgery in children
Creators: name: XiWang Liu
name: Chen, QiXing
name: Luo, YuJia
name: YaoQin Hu
name: DengMing Lai
name: Zhang, XiaoLe
name: Zhang, XiangHong
name: JianGen Yu
name: Fang, XiangMing
name: Shu, Qiang
Publisher: name: figshare
Year: 2017
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Standard anesthesia and cardiopulmonary bypass protocol. (DOCX 14 kb)
ABŪ BAKR AL-KĀSĀNĪ'S WORK " BADĀʾIʿ AL-ṢANĀʾIʿ FI TARTIB ASH-SHARA'I'" IN THE WORK OF THE UNIQUE METHODS OF SORTING FIQH RULES
Creators: name: Qambarov, A'zam
Publisher: name: Zenodo
Year: 2024

description: The opinions expressed in the article are formulated in accordance with the requirements of the methodological principles and traditional methods of the Ḥanafī faith. Opinions on social welfare are observed on the basis of modern standards based on the book "Badā’i‘ al-ṣanā’i‘ fī tartīb al-sharā’i‘" written by the jurist of Samarkand, Abū Bakr al-Kāsānī, and based on the jurisprudence rules and legal arguments introduced in Central Asia in general, in particular in our Republic.
Probing the BFKL dynamics in inclusive three jet production at the LHC
Creators: name: Caporale, F.
name: Celiberto, F. G.
name: Chachamis, G.
name: Gomez, D. Gordo
name: Vera, A. Sabio
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We propose the study of new observables in LHC inclusive events with three tagged jets, one in the forward direction, one in the backward direction and both well-separated in rapidity from the each other (Mueller-Navelet jets), together with a third jet tagged in central regions of rapidity. Since non-tagged associated mini-jet multiplicity is allowed, we argue that projecting the cross sections on azimuthal-angle components can provide several distinct tests of the BFKL dynamics. Realistic LHC kinematical cuts are introduced.
description: 8 pages. Talk given by G. Chachamis at the 5th International Conference on New Frontiers in Physics (ICNFP2016), 6-14 July 2016, Kolymbari, Crete, Greece
title: Study Room of University under the Background of Characteristic Culture: Research on Interior Space Environment Design
Creators: name: Xiangyan Li
Publisher: name: สถาบันเทคโนโลยีนวัตกรรมทางการศึกษาและการวิจัยแห่งสุวรรณภูมิ (สนว.)
publisherIdentifierScheme: ROR
Year: 2025
Subjects: Ningxia Culture
University Study Rooms
Interior Space Design
Cultural Identity
Inclusive Education

description: วารสารนวัตกรรมการศึกษาและการวิจัย, 9, 1, 614-629
Identification of the potential dual inhibitor of protein tyrosine phosphatase sigma and leukocyte common antigen-related phosphatase by virtual screen, molecular dynamic simulations and post-analysis
Creators: name: Zhou, Liang
name: Ma, Yang-Chun
name: Tang, Xue
name: Li, Wei-Ya
name: Ma, Ying
name: Wang, Run-Ling
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: Owing to their inhibitory role in regulating oligodendrocyte differentiation and apoptosis, protein tyrosine phosphatase sigma (PTPσ) and leukocyte common antigen-related phosphatase (LAR) play a crucial potential role in treating spinal cord injury (SCI) disease. In this research, the computer aided drug design (CADD) methods were applied to discover the potential dual-target drug involving virtual screen, molecular docking and molecular dynamic simulation. Initially, the top 20 compounds with higher docking score than the positive controls (ZINC13749892, ZINC14516161) were virtually screened out from NCI and ZINC databases, and then were submitted in ADMET to predict their drug properties. Among these potential compounds, ZINC72417086 showed a higher docking score and satisfied Lipinski’s rule of five. In addition, the post-analysis demonstrated that when ZINC72417086 bound to PTPσ and LAR, it could stable proteins conformations and destroy the residues interactions between P-loop and other loop regions in active pocket. Meanwhile, residue ARG1595 and ARG1528 could play a crucial role in in the inhibition of PTPσ and LAR, respectively. This research offered a novel approach for rapid discovery of dual-target leads compounds to treat SCI. Communicated by Ramaswamy H. Sarma
On the accurate computation of the true contact-area in mechanical contact of random rough surfaces
Creators: name: Yastrebov, Vladislav A.
name: Anciaux, Guillaume
name: Molinari, Jean-Francois
Publisher: name: arXiv
Year: 2017
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Classical Physics (physics.class-ph)
subject: FOS: Physical sciences

description: We introduce a corrective function to compensate errors in contact area computations coming from mesh discretization. The correction is based on geometrical arguments and requires only one additional quantity to be computed: the length of contact/non-contact interfaces. The new technique enables us to evaluate accurately the true contact area using a coarse mesh for which the shortest wavelength in the surface spectrum reaches the grid size. The validity of the approach is demonstrated for surfaces with different fractal dimensions and different spectral content using a properly designed mesh convergence test. In addition, we use a topology preserving smoothing technique to adjust the morphology of contact clusters obtained with a coarse grid.
description: 17 pages
Crossed lines: an analysis of the Pan-Grave ceramic tradition in Upper Egypt, Lower Nubia and beyond
Creators: name: De Souza, Aaron M.
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: The enigmatic Pan-Grave culture is archaeologically attested in the Nile Valley of Upper Egypt and Lower Nubia from the late Middle Kingdom until the end of the Second Intermediate Period. Despite being known to Egyptology for over a century, uncertainty still surrounds their true identity, their place in Egyptian and Nubian society, their origins, and their eventual fate. This thesis aims to address these and other issues through a dedicated study of the most abundant and accessible of Pan-Grave material remains - their ceramics. The analysis is divided into three parts: Part One identifies the issues that are central to the thesis, critically evaluates existing literature, introduces the datasets being analysed, and lays out the aims and methodology of the analysis. Part Two analyses pottery from confirmed Pan-Grave sites across Upper Egypt and Lower Nubia to establish the key characteristics that define the Pan-Grave ceramic tradition. The morphological aspects investigated include vessel form, fabric, ware and surface treatment,and decoration. Part Three contextualises the Pan-Grave ceramic tradition based on the defining criteria identified in Part Two. Pottery from sites in Upper Nubia, the Eastern Desert, and the Western Desert oases, and from Egyptian cultural contexts will be brought into the analysis to ensure the fullest possible coverage of the Pan-Grave ceramic tradition. An analysis of pottery distribution aims to identify any regional variation and chronological developments in Pan-Grave pottery. Part Three includes a cladistic analysis to identify any evolutionary developments in Pan-Grave pottery decoration. Three main outcomes are reached: First, it is shown that a relative chronological sequence can be constructed using certain aspects of the Pan-Grave ceramic tradition in relation to dateable Egyptian artefacts. Second, that this relative chronological sequence can assist in developing and re-evaluating theories relating to the origins and fate of the Pan-Grave people. Finally,that the identity of the Pan-Grave culture and its relationships with other contemporary cultures should be reconsidered in light of new evidence.
The status and challenges for prostate SBRT treatments in United States proton therapy centers: An NRG Oncology practice survey
Creators: name: Shen, Jiajian
name: Taylor, Paige A.
name: Vargas, Carlos E.
name: Kang, Minglei
name: Saini, Jatinder
name: Zhou, Jun
name: Wang, Peilong
name: Liu, Wei
name: Simone, Charles B.
name: Xiao, Ying
name: Lin, Liyong
Publisher: name: arXiv
Year: 2024
Subjects: subject: Medical Physics (physics.med-ph)
subject: FOS: Physical sciences

description: A survey was designed to inquire about the practice of proton SBRT treatment for prostate cancer. The survey was distributed to all 30 proton therapy centers in the United States that participate in the National Clinical Trial Network in Feb. 2023. The survey focused on usage, patient selection criteria, prescriptions, target contours, dose constraints, treatment plan optimization and evaluation methods, patient-specific QA, and IGRT methods. Results: We received responses from 25 centers (83% participation). Only 8 respondent proton centers (32%) reported performing SBRT of the prostate. The remaining 17 centers cited three primary reasons for not offering this treatment: no clinical need, lack of volumetric imaging, and/or lack of clinical evidence. Only 1 center cited the reduction in overall reimbursement as a concern for not offering prostate SBRT. Several common practices among the 8 centers offering SBRT for the prostate were noted, such as using Hydrogel spacers, fiducial markers, and MRI for target delineation. Most proton centers (87.5%) utilized pencil beam scanning (PBS) delivery and completed Imaging and Radiation Oncology Core (IROC) phantom credentialing. Treatment planning typically used parallel opposed lateral beams, and consistent parameters for setup and range uncertainties were used for plan optimization and robustness evaluation. Measurements-based patient-specific QA, beam delivery every other day, fiducial contours for IGRT, and total doses of 35-40 GyRBE were consistent across all centers. However, there was no consensus on the risk levels for patient selection. Conclusion: Prostate SBRT is used in about 1/3 of proton centers in the US. There was a significant consistency in practices among proton centers treating with proton SBRT. It is possible that the adoption of proton SBRT may become more common if proton SBRT is more commonly offered in clinical trials.
Additional file 2: Figure S2. of Small field dosimetry for the small animal radiotherapy research platform (SARRP)
Creators: name: Ghita, Mihaela
name: McMahon, Stephen
name: Thompson, Hannah
name: McGarry, Conor
name: King, Raymond
name: Osman, Sarah
name: Kane, Jonathan
name: Tulk, Amanda
name: Schettino, Giuseppe
name: Butterworth, Karl
name: Hounsell, Alan
name: Prise, Kevin
Publisher: name: figshare
Year: 2017
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Ecology
subject: Marine Biology
subject: Cancer

description: Beam uniformity profile across the irradiated area for full set of therapeutic apertures. Beam profiles are presented for three different SSD at a depth of 0.15 mm in the phantom. Apertures sizes are: a) 5 × 5 mm, b) 3 × 3 mm, c) 3x9mm along x axis, d) 3x9mm along y axis, e) 1 mm diameter and f) 0.5 mm diameter. (PDF 317 kb)
Writing Order Recovery in Complex and Long Static Handwriting
Creators: name: Diaz, Moises
name: Crispo, Gioele
name: Parziale, Antonio
name: Marcelli, Angelo
name: Ferrer, Miguel A.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: The order in which the trajectory is executed is a powerful source of information for recognizers. However, there is still no general approach for recovering the trajectory of complex and long handwriting from static images. Complex specimens can result in multiple pen-downs and in a high number of trajectory crossings yielding agglomerations of pixels (also known as clusters). While the scientific literature describes a wide range of approaches for recovering the writing order in handwriting, these approaches nevertheless lack a common evaluation metric. In this paper, we introduce a new system to estimate the order recovery of thinned static trajectories, which allows to effectively resolve the clusters and select the order of the executed pen-downs. We evaluate how knowing the starting points of the pen-downs affects the quality of the recovered writing. Once the stability and sensitivity of the system is analyzed, we describe a series of experiments with three publicly available databases, showing competitive results in all cases. We expect the proposed system, whose code is made publicly available to the research community, to reduce potential confusion when the order of complex trajectories are recovered, and this will in turn make the trajectories recovered to be viable for further applications, such as velocity estimation.
Los siete dolores que pasó Maria Santísima en la sacrada pasión y muerte de su amantísimo hijo: Digital edition
Creators: name: Leblanc Elina
Publisher: name: Zenodo
Year: 2024
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2024), led by professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Genomic map of candidate human imprint control regions: the imprintome
Creators: name: Jima, Dereje D.
name: Skaar, David A.
name: Planchart, Antonio
name: Motsinger-Reif, Alison
name: Cevik, Sebnem E.
name: Park, Sarah S.
name: Cowley, Michael
name: Wright, Fred
name: House, John
name: Liu, Andy
name: Jirtle, Randy L.
name: Hoyo, Cathrine
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Imprinted genes – critical for growth, metabolism, and neuronal function – are expressed from one parental allele. Parent-of-origin-dependent CpG methylation regulates this expression at imprint control regions (ICRs). Since ICRs are established before tissue specification, these methylation marks are similar across cell types. Thus, they are attractive for investigating the developmental origins of adult diseases using accessible tissues, but remain unknown. We determined genome-wide candidate ICRs in humans by performing whole-genome bisulphite sequencing (WGBS) of DNA derived from the three germ layers and from gametes. We identified 1,488 hemi-methylated candidate ICRs, including 19 of 25 previously characterized ICRs (https://humanicr.org/). Gamete methylation approached 0% or 100% in 332 ICRs (178 paternally and 154 maternally methylated), supporting parent-of-origin-specific methylation, and 65% were in well-described CTCF-binding or DNaseI hypersensitive regions. This draft of the human imprintome will allow for the systematic determination of the role of early-acquired imprinting dysregulation in the pathogenesis of human diseases and developmental and behavioural disorders.
A Combinatorial Approach to the Opposite Bi-Free Partial $S$-Transform
Creators: name: Skoufranis, Paul
Publisher: name: arXiv
Year: 2017
Subjects: subject: Operator Algebras (math.OA)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 46L54, 46L53

description: In this paper, we present a combinatorial approach to the opposite 2-variable bi-free partial $S$-transforms where the opposite multiplication is used on the right. In addition, extensions of this partial $S$-transforms to the conditional bi-free and operator-valued bi-free settings are discussed.
title: Eine Christliche Leichpredigt Bey der Volckreichen Leichbegängnuß deß Weyland Ehrwirdigen, Achbaren, vnd Wolgelerten Herrn M. Samvelis Nagelii geweßnen Diaconi bey der H. Reichs-Statt Rotenburg ob der Tauber; [1629]
title: Welcher Mittwochs den 15. Aprilis dieses 1629. Jahrs zu Nacht zwischen 1. vnd 2. Vhr deß grössern Zeigers im 64. Jahr seines Alters, vnd 38. Jahr seines Predigampts, sanfft vnd Seelig in Christo seinem Erlöser eingeschlaffen. Vnd darauff Freytags den 17. diß Christlichem löblichem gebrauch nach, ehrlich zu seinem Ruhbettlein begleitet worden
titleType: Subtitle
Creators: name: Renger, Michael
name: Nagel, Samuel
name: Körnlein, Hieronymus
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2023

description: Die Rückseite des Titelblatts ist unbedruckt. - Das letzte Blatt der Lage D ist unbedruckt
Semaphorin 3A Inhibits Endoplasmic Reticulum Stress Induced by High Glucose in Müller Cells
Creators: name: Li, Mengyang
name: Jin, Enzhong
name: Zhu, Li
name: Ren, Chi
name: Liang, Zhiqiao
name: Zhao, Mingwei
name: Qu, Jinfeng
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: This study aimed to explore the effect of the Semaphorin3A (Sema3A)/Neuropilin-1 (Nrp-1) pathway on Müller cell activities and endoplasmic reticulum (ER) stress induced by high glucose (HG) in vitro. The primary Müller cells of C57BL/6J mice were isolated and cultured in normal or high glucose medium. The expression of endogenous Sema3A and its coreceptor Nrp-1 was measured by Western blot. Müller cells were incubated with exogenous recombinant Sema3A protein or transfected with lentiviral vectors expressing small hairpin RNA (shRNA) to knock down the expression of endogenous Sema3A. The proliferation of Müller cells was detected by CCK-8 assay and EdU staining. The migratory ability was detected by the Transwell migration assay. The level of endoplasmic reticulum (ER) stress was analyzed through the detection of GRP78/BiP, IRE1α, phosphorylated IRE1αS724 (p-IRE1αS724), and the splicing rate of XBP1 (XBP1s/XBP1) by using immunofluorescence, Western blot or quantitative polymerase chain reaction (qPCR). HG induced the upregulation of endogenous Sema3A and Nrp-1 receptors in Müller cells. The expression of GRP78/BiP and IRE1α was upregulated by HG, with an increased splicing rate of XBP1. Exogenous Sema3A inhibited HG-induced Müller cell proliferation, migration, and GRP78/BiP-IRE1α-XBP1 axis activation. Knockdown of Sema3A promoted proliferation, migration, and ER stress induced by high glucose in Müller cells. Sema3A inhibited the increased proliferative and migratory activities induced by high glucose by attenuating ER stress in Müller cells.
Additional file 7: Table S2. of Association between continuous hyperosmolar therapy and survival in patients with traumatic brain injury – a multicentre prospective cohort study and systematic review
Creators: name: Asehnoune, Karim
name: Lasocki, Sigismond
name: Seguin, Philippe
name: Geeraerts, Thomas
name: Perrigault, Pierre
name: Dahyot-Fizelier, Claire
name: Burtz, Catherine Paugam
name: Cook, Fabrice
name: Latte, Dominique Demeure Dit
name: Cinotti, Raphael
name: Mahe, Pierre
name: Fortuit, Camille
name: Pirracchio, Romain
name: Feuillet, Fanny
name: Sébille, Véronique
name: Roquilly, Antoine
Publisher: name: figshare
Year: 2017
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: Detailed characteristics of eligible studies. (DOC 53 kb)
Nirogacestat: First Approval
Creators: name: Keam, Susan
Publisher: name: Adis Journals
Year: 2024
Subjects: Medicine

description: Declarations
Funding The preparation of this review was not supported by any external funding.
Authorship and Conflict of interest During the peer review process the manufacturer of the agent under review was offered an opportunity to comment on the article. Changes resulting from any comments received were made by the authors on the basis of scientific completeness and accuracy. Susan J. Keam is a contracted employee of Adis International Ltd/Springer Nature, and declares no relevant conflicts of interest. All authors contributed to this article and are responsible for its content.
Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability Not applicable.
Additional information about this Adis Drug Review can be found here. 

Abstract
Nirogacestat (OGSIVEO™) is an oral, selective, reversible, small molecule γ-secretase inhibitor developed by SpringWorks Therapeutics, Inc. γ-Secretase is a multi-subunit protease complex that cleaves multiple transmembrane protein complexes, including Notch and membrane-bound B-cell maturation antigen (BCMA). Inhibition of γ-secretase may result in growth inhibition of tumour cells overexpressing Notch, and preservation of membrane-bound BCMA may increase target density for BCMA-targeted therapy. In November 2023, nirogacestat was approved in the USA for use in adult patients with progressing desmoid tumours who require systemic treatment. This article summarizes the milestones in the development of nirogacestat leading to this first approval for the systemic treatment of desmoid tumours.
© Springer Nature Switzerland AG 2024
Los siete dolores que pasó Maria Santísima en la sacrada pasión y muerte de su amantísimo hijo: Digital edition
Creators: name: Leblanc Elina
Publisher: name: Zenodo
Year: 2021
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2022), led by the professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Discovery of proteins and pathways contributing to TDP-43-mediated neurodegeneration in a novel transgenic mouse model of disease
Creators: name: Gul, Hossai
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Motor neuron disease (MND)/amyotrophic lateral sclerosis (ALS) is an incurable and fatal neurodegenerative disease caused by progressive loss of motor neurons controlling movement. The main pathology exhibited by 97% of ALS cases is the aggregation of the RNA/DNA-binding protein TDP-43 within the cytoplasm of affected neurons. Although ALS pathology is characterised by TDP-43 accumulation, it is not understood how this dysfunction causes disease, meaning that it has not been possible to design disease-modifying therapeutics. To combat this issue, a new transgenic mouse model was created to develop the disease as presented in humans which exhibits both pathology as well as a disease phenotype very similar to human ALS. Using the new transgenic mouse model, a large-scale advanced quantitative mass spectrometry (SWATH-MS) study was performed to discover the protein changes involved in TDP-43-mediated pathogenesis. Mass spectrometry results were analysed using several methods ranging from singular protein analysis (Uniprot), to comprehensive analyses (Ingenuity Pathway Analysis). Quantitative immunoblotting and immunofluorescence was used to validate mass spectrometry results. Identified the proteins and pathways which changed during disease course within NLS TDP-43 mice model of ALS. Two key proteins, COQ9 and IMA3, which are involved in known mechanisms of ALS pathogenesis were validated using immunoblotting. In addition, the canonical pathways, upstream regulators and biological function involved in rNLS TDP-43 pathology were comprehensively identified. This study provides important insights into TDP-43-mediated ALS neurodegeneration.
title: Mappa breve da Lusitania antiga
Creators: name: Manoel De Nascimento (Le P. Francisco)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: 16°
description: Source: Bibliothèque patrimoniale Villon (Rouen), fonds Leber, Mt p 9978
Additional file 1: of Resource competition promotes tumour expansion in experimentally evolved cancer
Creators: name: Taylor, Tiffany
name: Wass, Anastasia
name: Johnson, Louise
name: Dash, Phil
Publisher: name: figshare
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Hematology

description: Figure S1. Histogram showing distribution of distance to point measurements after 0.25, 24 and 48Â h. Blue bars represent ancestral populations, green bars represent populations evolved in low resource supply (0.5% FBS) and pink bars represent populations evolved in high resource supply (5.0% FBS). (PDF 5Â kb)
Therapeutic Efficacy of Glial Cell Line-Derived Neurotrophic Factor Loaded Collagen Scaffolds in ex vivo organotypic brain slice Parkinson`s Disease Models
Creators: name: Ucar, Buket
name: Humpel, Christian
Publisher: name: Zenodo
Year: 2019
Subjects: Parkinson's disease, collagen scaffold, GDNF, organotypic brain slices

description: In this talk, we highlighted the results of our recent paper on the neuroprotective effects of GDNF loaded collagen scaffolds on ex vivo Parkinson's disease models with organotypic brain slice cultures.
Lindblad dynamics from spatio-temporal correlation functions in nonintegrable spin-1/2 chains with different boundary conditions
Creators: name: Kraft, Markus
name: Richter, Jonas
name: Jin, Fengping
name: Nandy, Sourav
name: Herbrych, Jacek
name: Michielsen, Kristel
name: De Raedt, Hans
name: Gemmer, Jochen
name: Steinigeweg, Robin
Publisher: name: arXiv
Year: 2024
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We investigate the Lindblad equation in the context of boundary-driven magnetization transport in spin-$1/2$ chains. Our central question is whether the nonequilibrium steady state of the open system, including its buildup in time, can be described on the basis of the dynamics in the closed system. To this end, we rely on a previous work [Phys. Rev. B 108, L201119 (2023)], where a description in terms of spatio-temporal correlation functions has been suggested in the case of weak driving and small system-bath coupling. Because this work has focused on integrable systems and periodic boundary conditions, we here extend the analysis in three directions: We (i) consider nonintegrable systems, (ii) take into account open boundary conditions and other bath-coupling geometries, and (iii) provide a comparison to time-evolving block decimation. While we find that nonintegrability plays a minor role, the choice of the specific boundary conditions can be crucial, due to potentially nondecaying edge modes. Our large-scale numerical simulations suggest that a description based on closed-system correlation functions is an useful alternative to already existing state-of-the-art approaches.
description: 12 pages, 12 figures
Suzaku spectroscopy of the neutron star transient 4U 1608-52 during its outburst decay
Creators: name: Padilla, M. Armas
name: Ueda, Y.
name: Hori, T.
name: Shidatsu, M.
name: Muñoz-Darias, T.
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We test the proposed 3-component spectral model for neutron star low mass X-ray binaries using broad-band X-ray data. We have analysed 4 X-ray spectra (0.8-30 keV) obtained with Suzaku during the 2010 outburst of 4U 1608-52, which have allowed us to perform a comprehensive spectral study covering all the classical spectral states. We use a thermally Comptonized continuum component to account for the hard emission, as well as two thermal components to constrain the accretion disc and neutron star surface contributions. We find that the proposed combination of multicolor disc, single-temperature black body and Comptonization components successfully reproduces the data from soft to hard states. In the soft state, our study supports the neutron star surface (or boundary layer) as the dominant source for the Comptonization seed photons yielding the observed weak hard emission, while in the hard state both solutions, either the disc or the neutron star surface, are equally favoured. The obtained spectral parameters as well as the spectral/timing correlations are comparable to those observed in accreting black holes, which support the idea that black hole and neutron star low mass X-ray binaries undergo a similar state evolution during their accretion episodes.
description: 8 pages, 4 figures, 2 tables. Accepted for publication in MNRAS
High blood pressure and cyclic stretch after cerebral amyloid deposition and endothelial function
Creators: name: Gangoda, Sumudu V. S.
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Background: Amyloid β (Aβ) deposition is a hallmark of Alzheimer’s disease (AD). Increased pulsatility, endothelial dysfunction (ED) and inflammation, indicators of vascular stiffness, are associated with AD. Additionally, vascular stiffness is linked to hypertension, a risk factor for AD. Aim: This study aimed to determine effects of high blood pressure (BP) on cerebral Aβ deposition in rodent models, spontaneously hypertensive (SHR) and normotensive Wistar Kyoto rats (WKY) and investigate effects of cyclic stretch (CS) on expression of amyloid precursor protein (APP), endothelial nitric oxide synthase (eNOS) and intercellular cell adhesion molecule-1 (ICAM-1) in human cerebral microvascular endothelial cells (hCMEC). Methods: Hippocampal (HC) and frontal cortex (FC) regions of SHR and WKY rats were analysed using western blotting to determine effect of BP on cerebral Aβ deposition. hCMEC were subjected to 5%, 10% or 20 % CS compared to control (0% CS) to evaluate pulsatility, ED and inflammation using western blotting and/or RTqPCR. Results: Aβ oligomerisation increased in SHR compared to WKY in HC (P<0.01) and FC (P<0.001). APP mRNA expression increased at 5%, decreased at 20% CS; eNOS decreased at both (P<0.0001). APP and ICAM-1 protein expression dose-dependently increased at 5% and 10% CS (P<0.01) and decreased at 20% CS. eNOS protein levels decreased at all CS (P<0.0001). Conclusions: Results suggest that high BP and CS respectively alter the processing and expression of cerebral APP. Prolonged CS may induce ED by increasing ICAM-1, thereby mitigating eNOS expression. Findings mechanistically support the association of elevated pulsatility and arterial stiffness with AD.
Additional file 8: Figure S5. of Global transcriptional landscape and promoter mapping of the gut commensal Bifidobacterium breve UCC2003
Creators: name: Bottacini, Francesca
name: Aldert Zomer
name: Milani, Christian
name: Ferrario, Chiara
name: Lugli, Gabriele
name: Egan, Muireann
name: Ventura, Marco
name: Sinderen, Douwe Van
Publisher: name: figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: B. breve regulatory RNA expression. Artemis plot showing the regulatory RNA transcription in B. breve of a) FMN, b) TPP, and c) YKOK elements. In all cases tiling array signals of forward (red) and reverse (blue) strand are indicated. (PDF 732Â kb)
title: ADCO, Cinquième cartulaire de Saint-Étienne de Dijon (1664), Cart. 28 (G 132), 258 folios, f. 00500
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Cinquième cartulaire de Saint-Étienne de Dijon (1664), Archives départementales de la Côte-d'Or, Cart. 28 (G 132), 258 folios, f. 00500, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cinquième cartulaire de Saint-Étienne de Dijon (1664), Archives départementales de la Côte-d'Or, Cart. 28 (G 132), 258 folios, f. 00500, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
High-scale baryogenesis with testable neutron-antineutron oscillation and dark matter
Creators: name: Gu, Pei-Hong
name: Sarkar, Utpal
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We propose a new scenario for predicting a one-loop neutron-antineutron oscillation at a testable level, meanwhile, realizing a thermal or inflationary baryogenesis at a very high scale. Besides the standard model content, this scenario involves two real singlet scalars with very heavy masses, two color-triplet and iso-singlet scalars at the TeV scale, as well as a Majorana singlet fermion for a dark matter candidate.
description: 5 pages, 2 figures
title: การจัดการมหาวิทยาลัยสู่ความเป็นเลิศ ของมหาวิทยาลัยเทคโนโลยีราชมงคลรัตนโกสินทร์
Creators: name: อมรรัตน์ เอกชาวนา
Publisher: name: สถาบันเทคโนโลยีนวัตกรรมทางการศึกษาและการวิจัยแห่งสุวรรณภูมิ (สนว.)
publisherIdentifierScheme: ROR
Year: 2025
Subjects: การจัดการมหาวิทยาลัย
ความเป็นเลิศ
มหาวิทยาลัยเทคโนโลยีราชมงคลรัตนโกสินทร์

description: วารสารนวัตกรรมการศึกษาและการวิจัย, 9, 1, 630-642