cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Dynamic response of seabed in wind power of deep-shallow sea induced by internal solitary waves
Creators: name: Xiang, Jiaming
name: Tian, Zhuangcai
name: Dong, Youkou
name: Zhao, Enjin
name: Song, Lei
name: Yue, Jianhua
name: Zhou, Guoqing
name: Liu, Xiaolei
name: Guo, Xiujun
name: Jia, Yonggang
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Marine Biology

description: With the development of offshore wind power projects worldwide, the stability of deep and shallow sea wind power sites has become a crucial concern. Internal solitary waves (ISWs) are nonlinear and large amplitude waves in the stratified ocean. Their strong vertical and horizontal motion and vorticity and turbulence caused by fragmentation have an important impact on the marine environment, seabed sediments, and marine engineering. This study focuses on the interaction between ISWs and the seabed of wind power sites in deep and shallow seas. Specifically, we investigate the interaction between ISWs and monopile foundations or floating fan plate anchor structures in the seabed. Through the simulation of CFD software and Comsol software, a law of seabed pore pressure variation during the effect of ISWs on the structure can be well demonstrated. Our results demonstrate that ISWs induce the accumulation of excess pore water pressure around the structures. The monopile foundation experiences negative excess pore water pressure at its bottom and the plate anchor at its top. The pore water pressure at the bottom of the monopile foundation initially decreases and then increases. In contrast, the pore water pressure at the right side of the monopile foundation increases, decreases, and then increases. This phenomenon promotes the settlement of the structure. At the bottom of the plate anchor, there is a sharp increase in positive excess pore water pressure by ISW. The pore water pressure above the plate anchor structure initially decreases and then increases, while below the plate anchor, it increases and then decreases. This phenomenon leads to the movement of the anchorage structure and instability of the surrounding soil. The influence of ISWs on the seabed bottom intensifies with the obstruction of the structure, resulting in significant positive pressure at the bottom. Between the two anchoring structures, there is increased seepage of pore water, making the seabed more prone to instability. Through the study of this article, we know that ISW has different effects on the force of monopile foundation and plate anchor structure, which provides a favorable basis for its design and maintenance.
Deciphering a regulatory atlas of germ cell development
Creators: name: Fan, Qi
Publisher: name: Monash University
Year: 2024
Subjects: classificationCode: 310102
subject: Cell development, proliferation and death

description: Germ cell development is an essential process to transfer genetic information from parents to children, but the genetic regulation of this process is not fully understood. This thesis provides a comprehensive genetic map for the control of germ cell development and provides a foundation for detailed genetic analysis in the future.
«we will never fully reveal» the truth about Paul Cameron’s fake denials and deliberate data concealment, as well as a full response to criticism in his direction
Creators: name: Research, Palette
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 440506
subject: Sexualities
classificationCode: 390406
subject: Gender, sexuality and education
classificationCode: 320221
subject: Psychiatry (incl. psychotherapy)

description: The work of a psychologist like Paul Cameron is considered incorrect, distorted as an axiom.
In fact, most critics do not conduct a detailed data search and base their opinion only on the
presence of criticism, forgetting about possible answers and refutations. In this article, I
provide the Cameron group's responses to all the criticism, my article is a data analysis, but
despite this, I criticized some of Cameron's criticism on my own. I come to the conclusion that
Cameron's conclusions are not disputed.
Additional file 1 of The efficacy of tixagevimab/cilgavimab (Evusheld) in prophylaxis and treatment of COVID-19 in immunocompromised patients: a systematic review and meta-analysis
Creators: name: Glhoom, Shaymaa
name: Fergany, Aya
name: El-Araby, Dina
name: Abdelkhalek, Asmaa A.
name: Gomaa, Asmaa
name: Zayed, Eman O.
name: Abd-ElGwad, Mohamed
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 1. Search strategy
Additional file 2 of The efficacy of tixagevimab/cilgavimab (Evusheld) in prophylaxis and treatment of COVID-19 in immunocompromised patients: a systematic review and meta-analysis
Creators: name: Glhoom, Shaymaa
name: Fergany, Aya
name: El-Araby, Dina
name: Abdelkhalek, Asmaa A.
name: Gomaa, Asmaa
name: Zayed, Eman O.
name: Abd-ElGwad, Mohamed
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 2: Table S1. This table shows the Newcastle–Ottawa quality assessment of 16 observational cohort studies. Table S2. Quality Assessment Tool for Case Series Studies.
Identification of Novel Pathways that Promote Anoikis through Genome-wide Screens
Creators: name: Pedanou, Victoria E.
Publisher: name: University of Massachusetts Medical School
Year: 2016

description: Epithelial cells that lose attachment to the extracellular matrix (ECM) undergo a specialized form of apoptosis called anoikis. Anoikis has an important role in preventing oncogenesis, particularly metastasis, by eliminating cells that lack proper ECM cues. The basis of anoikis resistance remains to be determined and to date has not been linked to alterations in expression or activity of previously identified anoikis effector genes. Here, I utilized two different screening strategies to identify novel anoikis effector genes and miRNAs in order to gain a deeper understanding of anoikis and the potential mechanisms of anoikis resistance in cancer.  Using large-scale RNA interference (RNAi) screening, I found that KDM3A, a histone H3 lysine 9 (H3K9) mono- and di-demethylase plays a pivotal role in anoikis induction. In attached breast epithelial cells, KDM3A expression is maintained at low levels by integrin signaling. Following detachment, integrin signaling is decreased resulting in increased KDM3A expression. RNAi-mediated knockdown of KDM3A substantially reduces apoptosis following detachment and, conversely, ectopic expression of KDM3A induces cell death in attached cells. I found that KDM3A promotes anoikis through transcriptional activation of BNIP3 and BNIP3L, which encode pro-apoptotic proteins. Using mouse models of breast cancer metastasis I show that knockdown of Kdm3a enhances metastatic potential. Finally, I find defective KDM3A expression in human breast cancer cell lines and tumors. Collectively, my results reveal a novel transcriptional regulatory program that mediates anoikis. Next, I sought to discover miRNAs involved in anoikis by investigated changes in miRNA expression during anoikis using small RNA sequencing technology. Through this approach I discovered that miR-203 is an anoikis effector miRNA that is also highly down-regulated in invasive breast cancer cells. In breast epithelial cells, miR-203 is induced upon the loss of ECM attachment and inhibition of miR-203 activity leads to a resistance to anoikis. I utilized a dual functional- and expression- based RNA sequencing approach and found that miR-203 directly targets a network of pro-survival genes to induce cell death upon detachment. Finally, I found that the loss of miR-203 in invasive breast cancer leads to the elevation of several anoikis-related pro-survival target genes to contribute to anoikis resistance. Taken together, my studies reveal novel pathways through which cell death is induced upon detachment from the ECM and provide insight into potential mechanisms of anoikis resistance in cancer.
THE ROLE OF METHODS IN TEACHING WRITING
Creators: name: Sharipova, Nodira
Publisher: name: Zenodo
Year: 2024

description: Teaching writing effectively requires a range of approaches that address different learning goals and demands. These techniques include genre-based tactics, process-oriented procedures, and direct instruction. While process-oriented approaches place more emphasis on the processes of drafting, rewriting, and editing, direct instruction concentrates on the explicit teaching of writing norms and practices. Teaching pupils about various literary genres and their norms is a component of genre-based techniques. Every approach offers advantages of its own, adding to a whole writing program that improves students' capacity for effective and clear communication of ideas. The importance of these techniques and how they affect the development of skilled writers are examined in this abstract
Supporting data for: Widespread hydrological droughts are twice as severe as localized events within cold, humid catchments
Creators: name: Bastien-Beaudet, Gabriel
Publisher: name: Zenodo
Year: 2024

description: Supporting data for the article: Widespread hydrological droughts are twice as severe as localized events within cold,humid catchments. Contains datasets and R scripts to reproduce some of the analysis presented in the article.
Superloaded Multiplexed scRNA-seq Data Preserves Primary Immune Cell Heterogeneity but Necessitates Stringent Doublet Removal
Creators: name: Sserwadda, Henry
name: Lee, Jung Ho
name: Lee, Brian H
name: Jung, Sunyoung
name: Bang, Yoon Ji
name: Cho, Beom Keun
name: Nam, Hyo Jeong
name: Choi, So-Jung
name: Gong, Jeong-Ryeol
name: Choi, Hyun Seung
name: Jung, Chong Wook
name: Chung, Hyeyeon
name: Nam, Hyunsung
name: Kim, Eung Re
name: Kim, Hyun Je
name: Park, Chung-Gyu
name: Kim, Yong-Hee
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Single-cell RNA sequencing (scRNA-seq) has improved our ability to characterize rare cell populations. In practice, cells from different tissues or donors are simultaneously loaded onto the instrument (multiplexed) at the recommended (standard loading) or higher (superloading) numbers to save time and money. Although cost-effective, superloading can stymie computational analyses owing to high multiplet rates and sample complexity. We compared the effects of superloading on multiplexed single-cell gene expression and T cell receptor (TCR) data generated from human thymus and blood samples from different donors. Minimal transcriptomic differences were observed between the data generated by either standard or superloading. Irrespective of the loading cell number, we found that over 50% of the T cells expressing multiple TCR chains were doublets. Multiple samples can be run simultaneously without compromising data quality and subsequent analyses. However, an additional doublet removal step based on TCR configuration may improve the accuracy of T cell analysis.
Additional file 1 of Study of clinical traits and systemic immune inflammation index assessments in patients with endogenous endophthalmitis over the last ten years
Creators: name: Niu, Rui
name: Yan, Zhongyang
name: Wang, Yanhui
name: Li, Yalin
name: Feng, Wei
name: Liu, Jianan
name: Wang, Lifei
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy
subject: Hematology

description: Additional file 1: Fig. S1. shows that the ellipse represents the core area grouped by the default 68% confidence interval, the correlation ring (ie the circle, representing the correlation), and the arrow represents the principal component loading. Table S1. Spearman correlation study on blood routine test indicators, SII, NLR, PLR, MLR, age, and onset time.
Additional file 1 of Measurement properties of the EQ-5D in children and adolescents: a systematic review protocol
Creators: name: do Espirito Santo, Caique de Melo
name: Santos, Verônica Souza
name: Miyamoto, Gisela Cristiane
name: Chiarotto, Alessandro
name: Santos, Marisa
name: Yamato, Tiê Parma
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology

description: Additional file 1.
Additional file 2 of Measurement properties of the EQ-5D in children and adolescents: a systematic review protocol
Creators: name: do Espirito Santo, Caique de Melo
name: Santos, Verônica Souza
name: Miyamoto, Gisela Cristiane
name: Chiarotto, Alessandro
name: Santos, Marisa
name: Yamato, Tiê Parma
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology

description: Additional file 2.
The AnaConDa® and Sevoflurane in the ICU: data on ambient pollution and staff exposure
Creators: name: Bos, Alex T.
name: Thomas, Oliver
Publisher: name: F1000Research
Year: 2017

description: The AnaConDa®  (Sedana Medical, Uppsala, Sweden) is a reflection filter that can be used to administer volatile anesthetics to intubated patients on a conventional ventilator outside the OR. We have recently implemented sevoflurane as a sedative in our ICU and found that little data are available on staff exposure and ambient pollution when using the AnaConDa®. An independent risk analyses was performed, as requested by our occupational health service. We have measured ambient pollution, staff exposure and peak values of sevoflurane on all connection points of the AnaConDa® system and FlurAbsorb scavenger in a Critical Care setting.  Aim of this study was to quantify ambient pollution and staff exposure to sevoflurane while using the AnaConDa®  and relate it to current safety standards.

We clearly show that peak concentrations and TWA are far below the allowed occupational exposure limits.

We concluded that sedation with sevoflurane and the AnaConDa® system with the FlurAbsorb scavenger is safe in an ICU setting. Occupational exposure is negligible and meets international standards. These data highly contributed to staff safety perception and awareness.  Our data may be helpful to those who want to implement volatile anesthetics in their ICU. Protocols should be used to ensure a standard way of care when using volatile anesthetics.
IL-37 Alleviates Sepsis-Induced Lung Injury by Inhibiting Inflammatory Response Through the TGF-β/Smad3 Pathway
Creators: name: Guo, Yufang
name: Deng, Feifei
name: Jiang, Yali
name: Cao, Guodong
name: Zhang, Yixin
name: Liu, Gaowu
name: Alimujiang, Mayinur
name: Ayati, Mairhaba
name: Chen, Yufeng
name: Chen, Lili
name: Lv, Su
name: Dou, Xueqin
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Introduction: Sepsis is caused by an uncontrolled inflammatory response and immune dysfunction, with lung injury being the most common complication and one of the leading causes of death in clinically ill patients. Interleukin 37 (IL-37) is a multifunctional cytokine that plays a vital role in various pathophysiological processes, including inflammation, infection, and immunity. Methods: The study involved both clinical and animal experiments (establishing an animal model of sepsis-induced lung injury). Firstly, 50 patients with sepsis-induced lung injury and 50 healthy controls were included. In addition, a more in-depth study was conducted using animal models. Results: IL-37, IL-6, PCT, and CRP levels were significantly higher in the sepsis-induced lung injury group. Correlation analysis revealed that IL-37 significantly correlated with IL-6, PCT, and CRP levels. In animal experiments, IL-37 significantly attenuated CLP-induced pulmonary edema and cellular injury while reducing the levels of inflammatory factors IL-6 and TNF-α, as well as sepsis-related inflammatory markers PCT and CRP. Moreover, IL-37 significantly downregulated the expression levels of genes and proteins of apoptosis-related molecules Caspase-3 and Bax and pathway molecules TGF-β and Smad3. Discussion: The TGF-β/Smad3 pathway is involved in the process of IL-37 inhibiting inflammatory response and ameliorating sepsis-induced lung injury.
lesser saints, on 22 April in the Martyrologium Hieronymianum: in Rome, Cordula (Persia), and elsewhere
Creators: name: Admin, CSLA
Publisher: name: University of Oxford
Year: 2018
Subjects: History

description: All evidence related to lesser saints, on 22 April in the Martyrologium Hieronymianum: in Rome, Cordula (Persia), and elsewhere.
Long read sequencing enables alternative transcript identification: a proof of concept
Creators: name: Coster, Wouter De
name: Roeck, Arne De
name: Dongen, Jasper Van
name: Broeckhoven, Christine Van
name: Cruts, Marc
Publisher: name: F1000Research
Year: 2017

description: As a first proof of concept, we amplified the OPTN transcript using single step reverse transcription and PCR amplification. This ~2.5kb amplicon was sequenced on the Oxford Nanopore MinION. Alignments using GMAP, GraphMap and STARlong were compared. The main outcome is the observation that alignment of the obtained reads using GMAP recapitulates the known exon structure annotation. Reference identity is lower than expected for gDNA sequencing projects, presumably due to alignment inaccuracies.
Origin of the twice ${90}^{\circ}$ rotations of the polarization angle in GRB 170114A and GRB 160821A
Creators: name: Wang, Xu
name: Lan, Mi-Xiang
name: Tang, Qing-Wen
name: Wu, Xue-Feng
name: Dai, Zi-Gao
Publisher: name: arXiv
Year: 2024
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The observed twice abrupt ${90}^{\circ}$ rotations of the polarization angle (PA) in the prompt phase of gamma-ray bursts (GRBs) are difficult to be understandable within the current one-emitting-shell models. Here, we apply a model with multiple emitting shells to solve this new challenging problem. Two configurations of large-scale ordered magnetic fields in the shells are considered: toroidal and aligned. Together with the light curves and the spectral peak-energy evolutions, the twice ${90}^{\circ}$ PA rotations in GRB 170114A and GRB 160821A could be well interpreted with the multi-shell aligned magnetic fields configuration. Our numerical calculations also show that the multiple shells with the toroidal magnetic field configuration could not explain the observed twice ${90}^{\circ}$ PA rotations. An aligned magnetic field configuration in the GRB outflow usually indicate to prefer a magnetar central engine, while a toroidal field configuration is typically related to a central black hole. Therefore, the magnetar central engines for the two GRBs are favored.
description: 13 pages, 6 figures, 4 tables, ApJ accepted
Injection process of pickup ion acceleration at an oblique heliospheric termination shock
Creators: name: Matsukiyo, S.
name: Matsumoto, Y.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: Injection process of pickup ion acceleration at a heliospheric termination shock is investigated. Using two-dimensional fully kinetic particle-in-cell simulation, accelerated pickup ions are self-consistently reproduced by tracking long time evolution of shock with unprecedentedly large system size in the shock normal direction. Reflected pickup ions drive upstream large amplitude waves through resonant instabilities. Convection of the large amplitude waves causes shock surface reformation and alters the downstream electromagnetic structure. A part of pickup ions are accelerated to tens of upstream flow energy in the time scale of $\sim 100$ times inverse ion gyro frequency. The initial acceleration occurs through shock surfing acceleration mechanism followed by shock drift acceleration mechanism. Large electrostatic potential accompanied by the upstream waves enables the shock surfing acceleration to occur.
description: 8 pages, 6 figures
Immunomodulatory Role and Therapeutic Potential of HLA-DR+ Regulatory T Cells in Systemic Lupus Erythematosus
Creators: name: Zhang, Jing
name: Liao, Bei
name: Wang, Xiaobing
name: Liu, Weijun
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Hematology

description: Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects multiple organ systems. A key element in maintaining immune tolerance and preventing autoimmunity is the role of regulatory T cells (Treg cells). Among these, HLA-DR+ Treg cells represent a distinct subset, and their altered expression and functionality in SLE are closely associated with the progression of the disease. This review explores the biological characteristics of HLA-DR+ Treg cells, their mechanisms of action in SLE, as well as their potential and the challenges they pose as therapeutic targets. This review offers a comprehensive analysis of the mechanisms by which HLA-DR+ Treg cells regulate immune responses. It highlights their direct interactions with autoreactive T cells and antigen-presenting cells, which contribute to the suppression of autoimmunity. Additionally, the review explores the critical role of these cells in maintaining immune tolerance and their promising potential in the context of antigen-specific immunotherapy. The potential of HLA-DR+ Treg cells in the treatment of systemic lupus erythematosus (SLE) is considerable, particularly due to their capacity to generate antigen-specific Tregs. The development of Treg-based therapies, including the expansion of both polyclonal and antigen-specific Tregs, is an area of active investigation. Nonetheless, several challenges persist, such as the need to optimize protocols for Treg generation and expansion, ensure the stability of the Treg phenotype, and address potential safety concerns associated with cellular therapies.Continued research is essential to fully harness the potential of HLA-DR+ Treg cells in the treatment of SLE and other autoimmune diseases.
Additional file 1 of Prevalence of and risk factors for iron deficiency among pregnant women with moderate or severe anaemia in Nigeria: a cross-sectional study
Creators: name: Babah, Ochuwa Adiketu
name: Akinajo, Opeyemi Rebecca
name: Beňová, Lenka
name: Hanson, Claudia
name: Abioye, Ajibola Ibraheem
name: Adaramoye, Victoria Olawunmi
name: Adeyemo, Titilope A.
name: Balogun, Mobolanle Rasheedat
name: Banke-Thomas, Aduragbemi
name: Galadanci, Hadiza S.
name: Sam-Agudu, Nadia A.
name: Afolabi, Bosede Bukola
name: Larsson, Elin C.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Supplementary file 1. Food frequency questionnaire
sj-pdf-1-mcr-10.1177_1077558720967227 – Supplemental material for The ACA Medicaid Expansions and Opioid Mortality: Is There a Link?
Creators: name: Rahi Abouk
name: Lorens Helmchen
name: Moghtaderi, Ali
name: Pines, Jesse
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, sj-pdf-1-mcr-10.1177_1077558720967227 for The ACA Medicaid Expansions and Opioid Mortality: Is There a Link? by Rahi Abouk, Lorens Helmchen, Ali Moghtaderi and Jesse Pines in Medical Care Research and Review
Immunomodulatory Effects of Pterocarpanquinone LQB-118 in Murine Peritoneal Macrophages
Creators: name: de Almeida Lima, Éssia
name: Cavalcante-Silva, Luiz Henrique Agra
name: Carvalho, Deyse Cristina Madruga
name: Soares, Mariana Mendonça
name: Medeiros, Anna Beatriz Araujo
name: Netto, Chaquip Daher
name: Costa, Paulo Roberto Ribeiro
name: Rodrigues-Mascarenhas, Sandra
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine

description: Phagocytosis is an important function of macrophages. However, when it’s dysregulated, it could compromise homeostasis. Thus, this study aimed to assess the inhibitory activity of pterocarpanquinone LQB 118 on murine macrophage phagocytosis. We used peritoneal macrophages isolated from mice to evaluate the impact of LQB 118 (5 μM) on the modulation of phagocytic activity and possible action mechanism related: IL-12 (by ELISA), NO (by Griess reaction),ROS production (by flow cytometry), and intracellular signaling proteins (iNOS, P-Akt, P-mTOR, NF-κB, and P-NF-κB) (by flow cytometry).The macrophages were stimulated with zymosan to assess both phagocytic activity and flow cytometry assays. Treatment with LQB 118 resulted in a reduction in the phagocytosis of zymosan particles by macrophages. This effect could potentially be attributed to LQB’s inhibition of IL-12 production and mTOR/NF-κB signaling. Furthermore, LQB 118 decreased the levels of ROS and NO without interfering with iNOS and Akt activation. These findings show the anti-phagocytic activity of LQB 118 on macrophage, highlighting the potential of this compound as a candidate for modulating macrophage-driven inflammation.
958900_Online_Appendix – Supplemental material for Electoral regimes and the politicisation of foreign trade in national elections
Creators: name: Taylor, Timothy W
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 160607 International Relations
subject: FOS: Political science

description: Supplemental material, 958900_Online_Appendix for Electoral regimes and the politicisation of foreign trade in national elections by Timothy W Taylor in The British Journal of Politics and International Relations
Additional file 2 of Prevalence of and risk factors for iron deficiency among pregnant women with moderate or severe anaemia in Nigeria: a cross-sectional study
Creators: name: Babah, Ochuwa Adiketu
name: Akinajo, Opeyemi Rebecca
name: Beňová, Lenka
name: Hanson, Claudia
name: Abioye, Ajibola Ibraheem
name: Adaramoye, Victoria Olawunmi
name: Adeyemo, Titilope A.
name: Balogun, Mobolanle Rasheedat
name: Banke-Thomas, Aduragbemi
name: Galadanci, Hadiza S.
name: Sam-Agudu, Nadia A.
name: Afolabi, Bosede Bukola
name: Larsson, Elin C.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2: Supplementary file 2. Summary of screening and inclusion into study by state and facility level.
Timosaponin A-III Alleviates Asthma-Induced Airway Inflammation, Th17 Cell Differentiation, and STAT3/RORγt Pathway
Creators: name: Wang, Lijie
name: Yuan, Jiabo
name: Zhao, Ruiqi
name: Wang, Congyao
name: Li, Zhuying
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: T helper 17 (Th17) cells have a significant effect in the pathogenesis of asthma, and signal transducer and activator of transcription 3 (STAT3) pathway activation is critical for Th17 cell differentiation. Timosaponin A-III (TA3) was reported to inhibit the STAT3 pathway. Here, we investigated whether TA3 improved asthma by inhibiting the STAT3 pathway.  Ovalbumin (OVA)-induced asthma murine models were developed, and TA3 (10 or 20 mg/kg) was gavage daily during OVA challenge. Murine naïve CD4+T cells were   triggered for Th17 differentiation, and TA3 (5 or 10 μM) was used to treat cells during induction of Th17 differentiation. In vivo experiments showed that TA3 decreased airway inflammation, goblet cell and smooth muscle hyperplasia, α-smooth muscle actin and collagen deposition, Th17 differentiation, and STAT3/RORγt signaling activation in mice exposed to OVA. The inhibitory effect of TA3 on STAT3/RORγt signaling activation was also observed in in vitro experiments. Compared to positive control static (a specific inhibitor of STAT3), TA3 had a similar effect on Th17 differentiation. These findings indicate that TA3 may ameliorate Th17 cell differentiation by suppressing STAT3/RORγt signaling. Our data provide evidence of the potential benefits of TA3 for the treatment of asthma.
lesser saints, on 27 April in the Martyrologium Hieronymianum: in Asia Minor, Pannonia, Italy, and Egypt
Creators: name: Admin, CSLA
Publisher: name: University of Oxford
Year: 2018
Subjects: History

description: All evidence related to lesser saints, on 27 April in the Martyrologium Hieronymianum: in Asia Minor, Pannonia, Italy, and Egypt .
lesser saints, on 28 April in the Martyrologium Hieronymianum: in Tarsus (Asia Minor), Africa, and Rome
Creators: name: Admin, CSLA
Publisher: name: University of Oxford
Year: 2018
Subjects: History

description: All evidence related to lesser saints, on 28 April in the Martyrologium Hieronymianum: in Tarsus (Asia Minor), Africa, and Rome.
Appendix_1_Secondary_outcome_measures – Supplemental material for Addition of aerobic training to conventional rehabilitation after hip fracture: a randomized, controlled, pilot feasibility study
Creators: name: Corna, Stefano
name: Arcolin, Ilaria
name: Giardini, Marica
name: Bellotti, Lucia
name: Godi, Marco
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 110314 Orthopaedics
subject: 110604 Sports Medicine
subject: FOS: Health sciences

description: Supplemental material, Appendix_1_Secondary_outcome_measures for Addition of aerobic training to conventional rehabilitation after hip fracture: a randomized, controlled, pilot feasibility study by Stefano Corna, Ilaria Arcolin, Marica Giardini, Lucia Bellotti and Marco Godi in Clinical Rehabilitation
Roman mosaics
Creators: name: Ajvazi, Irfan
Publisher: name: Humanities Commons
Year: 2023
Subjects: subject: Art and history

description: During the Roman Empire, mosaics were built in large rooms to make those rooms look more admirable and exciting. There was an architect that wrote a book about mosaics and how they were designed but this book did not include how the check (a pattern of small squares) was harvested or how they were set out this man's name is Vitruvius. He is the reason why there are so many mosaics post Roman Empire. They can tell stories of normal life or mythology or be portraits but the style of these mosaics varies from Rome to Northern Africa to Syria and many more. The style also reflects what decade or so years it is from. Take a mosaic from Syria of a griffin it would be different to a mosaic from Rome as you can see. This also proves my other point, that if they aren't in the same decade they will not be very similar as well as if they aren't in the same region of the Roman Empire. Furthermore the main deciphering factors between Roman Mosaics is the place, decade and/or the culture of the city or region is.
Application of the Monoclonal Autoantibody and Its Target Protein Derived from the Peripheral Blood of SLE Patients in Serological Diagnosis and Differential Diagnosis of SLE
Creators: name: Jin, Keting
name: Chen, Yalun
name: Ye, Yuyang
name: Ke, Qiang
name: Hong, Jinhui
name: Zhang, Kaibo
name: Wang, Leping
name: Ye, Jialu
name: Dong, Jiawen
name: Xu, Yongchao
name: Shan, Jiali
name: Zhao, Wenshan
name: Zhang, Yi
name: Wu, Jing
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder with limited reliable diagnostic biomarkers. This study evaluates the utility of DEAD-box helicase 5 (DDX5) as a diagnostic and differential marker for SLE and assesses the performance of a capture bead-based flow cytometry (CBFCM) method for detecting serum proteins. Serum samples were collected from 52 patients with SLE, 38 patients with rheumatoid arthritis (RA), 49 patients with lung cancer (LC), and 50 healthy controls (HCs). Levels of DDX5, anti-DDX5, anti-dsDNA, and anti-Sm were quantified using enzyme-linked immunosorbent assay (ELISA) and CBFCM. Serum DDX5 levels were significantly elevated in patients with SLE compared to patients with RA and HCs, correlating with the SLE activity. DDX5 demonstrated strong discriminatory power between SLE and RA. Combining DDX5, anti-dsDNA, and anti-Sm as biomarkers yielded an area under the curve (AUC) of 0.976 for SLE diagnosis. Decision curve analysis indicated a high clinical benefit from the combined biomarkers. The sensitivity and specificity of DDX5 were 66.11% and 88.89% for ELISA, and 72% and 91.3% for CBFCM. DDX5 shows promise as a novel serological biomarker for SLE diagnosis and differential diagnosis. Additionally, CBFCM outperforms ELISA in detecting soluble serum proteins.
sj-pdf-1-ibe-10.1177_1420326X20967974 - Supplemental material for Physical-radiation shielding properties of concrete contains colemanite and ulexite
Creators: name: Uçar, Nazım
name: Çalık, Adnan
name: Emre, Muhammet
name: Akkurt, Iskender
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies

description: Supplemental material, sj-pdf-1-ibe-10.1177_1420326X20967974 for Physical-radiation shielding properties of concrete contains colemanite and ulexite by Nazım Uçar, Adnan Çalık, Muhammet Emre and Iskender Akkurt in Indoor and Built Environment
On Relationalities: Politics, Narrative, Sociality (Call for Papers)
Creators: name: Edmeads, Luke
name: Griffin, Christopher
name: Primera, German
Publisher: name: unknown
Year: 2023
Subjects: subject: Decolonization--Social aspects
subject: Subjectivity
subject: Narration (Rhetoric)
subject: Queer theory
subject: Political science--Philosophy
subject: Socialites
subject: Black people--Race identity
subject: Ontology
subject: Critical race theory
subject: Political science
subject: FOS: Political science

description: A one-day hybrid symposium to be hosted by the Centre for Applied Philosophy, Politics and Ethics (CAPPE) at the University of Brighton (UK). Date: Wednesday 5 April 2023. Location: University of Brighton, City Campus, M2, and online. Keynote speaker: Dr Leticia Sabsay (LSE). Deadline for abstracts: Friday 24 February 2023. Please see poster for full details.
On Relationalities: Politics, Narrative, Sociality (Call for Papers)
Creators: name: Edmeads, Luke
name: Griffin, Christopher
name: Griffin, Christopher
Publisher: name: Humanities Commons
Year: 2023
Subjects: subject: Socialites
subject: Subjectivity
subject: Political science
subject: FOS: Political science
subject: Political science--Philosophy
subject: Black people--Race identity
subject: Critical race theory
subject: Queer theory
subject: Narration (Rhetoric)
subject: Decolonization--Social aspects
subject: Ontology

description: A one-day hybrid symposium to be hosted by the Centre for Applied Philosophy, Politics and Ethics (CAPPE) at the University of Brighton (UK). Date: Wednesday 5 April 2023. Location: University of Brighton, City Campus, M2, and online. Keynote speaker: Dr Leticia Sabsay (LSE). Deadline for abstracts: Friday 24 February 2023. Please see poster for full details.
lesser saints, on 29 April in the Martyrologium Hieronymianum: in Alexandria, Nicomedia, Italy, and elsewhere
Creators: name: Admin, CSLA
Publisher: name: University of Oxford
Year: 2018
Subjects: History

description: All evidence related to lesser saints, on 29 April in the Martyrologium Hieronymianum: in Alexandria, Nicomedia, Italy, and elsewhere .
Additional file 1 of First report on knockdown resistance mutations in wild populations of Aedes aegypti from Argentina determined by a novel multiplex high-resolution melting polymerase chain reaction method
Creators: name: Barrera-Illanes, Alberto N.
name: Micieli, María Victoria
name: Ibáñez-Shimabukuro, Marina
name: Santini, María Soledad
name: Martins, Ademir J.
name: Ons, Sheila
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 1: Detection of kdr single nucleotide polymorphism by melt curve analysis. Raw curves showing both 1016 (left peak) and 1534 (right peak) positions. Red kdr homozygous standard (R2R2), yellow heterozygous standard (SR2), green homozygous standard (SS). A Representative curve for the SR1 genotype (violet). B Representative curve for the R1R1 genotype (blue). C Representative curve for the R1R2 genotype (grey).
Adipose-Derived Mesenchymal Stem Cell Exosomes Encapsulating siIL1R2 Facilitate the Repair of DSS-Induced Intestinal Mucosal Injury
Creators: name: Gao, Song
name: Ge, Yajuan
name: Huang, He
name: Wang, Lei
name: Zhang, Wenbin
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Interleukin-1 receptor 2 (IL1R2) and C-C motif chemokine receptor 2 (CCR2) as critical mediators of immune modulation and inflammation. This study aims to evaluate their functions in dextran sulfate sodium (DSS)-induced intestinal injury. A DSS-induced intestinal injury model was established in C57BL/6 mice. Pharmacological inhibitors targeting IL1R2 or CCR2 were administered. Adipose-derived mesenchymal stem cell (ADMSC)-derived exosomes were isolated and loaded with IL1R2-siRNA, which were then administered to intestinal epithelial cells (IEC-6) or DSS-challenged mice. IL1R2 and CCR2 were upregulated in DSS-treated colon tissues. Pharmacological inhibition of IL1R2 or CCR2 improved body weight, restored colon length, reduced serum TNF-α and IL-6 levels, and preserved epithelial integrity in mice. miR-128-3p enriched in ADMSC-derived exosomes significantly reduced CCR2 expression in IEC-6 cells. Further loading of an IL1R2 siRNA in these exosomes led to a simultaneous inhibition of IL1R2. These exosomes reduced lipopolysaccharide-induced apoptosis and inflammation in IEC-6 cells and improved histological outcomes in DSS-challenged mice. IL1R2 and CCR2 are key mediators of inflammation in DSS-induced intestinal injury. Dual inhibition of IL1R2 and CCR2 holds great promise for alleviating inflammatory responses and improving histological presentations in inflammatory bowel disease.
Author_Response_1 – Supplemental material for Clinical characteristics and risk factors for severity of COVID-19 outside Wuhan: a double-center retrospective cohort study of 213 cases in Hunan, China
Creators: name: Hu, Xingsheng
name: Hu, Chunhong
name: Yang, Yong
name: Chen, Juan
name: Zhong, Ping
name: Wen, Yajing
name: Chen, Xiangyu
Publisher: name: SAGE Journals
Year: 2020
Subjects: Aged Health Care
Pharmacology and Pharmaceutical Sciences not elsewhere classified
Respiratory Diseases

description: Supplemental material, Author_Response_1 for Clinical characteristics and risk factors for severity of COVID-19 outside Wuhan: a double-center retrospective cohort study of 213 cases in Hunan, China by Xingsheng Hu, Chunhong Hu, Yong Yang, Juan Chen, Ping Zhong, Yajing Wen and Xiangyu Chen in Therapeutic Advances in Respiratory Disease
Festarbeit, Tafelloge, Zeremonial. Freimaurerei und höfische Gesellschaft
Creators: name: Berger, Joachim
Publisher: name: Humanities Commons
Year: 2004
Subjects: subject: Freemasonry
subject: Freemasonry--Rituals
subject: Courts and courtiers
subject: Etiquette
subject: Rites and ceremonies
subject: Goethe, Johann Wolfgang von, 1749-1832

description: Freemasonry has traditionally been seen as a key influence in the rise of the Bourgeoisie, since it allegedly subdued social boundaries and behavioural norms of the Ancien Régime. This paper, however, argues that the masonic lodges at least in the smaller German court towns, adopted various elements of court society – organizational structures, myths and ceremonies. These lodges imported the British model of the gentleman-freemason and combined it with customs and values of the secular orders of knighthood popular at courts. The most important masonic Grand Lodge, the Strict Observance, was ruled by an elitist 'Inner Order' that was modeled after the medieval Knights Templar. These masonic 'Knights' were searching for a new chivalric code. Moreover, the rituals of all lodges mimicked ceremonies at court, culminating in the Tafelloge. Freemasonry thus did not threaten court society. Its utopian potential lay in harmonizing its social and cultural inconsistencies.
Gelosia del sole. Girolamo Britonio. Ed. Mikaël Romanato. Travaux d'Humanism et Renaissance 597; Textes et Travaux de la Fondation Barbier-Mueller pour l’Étude de la poésie italienne de la Renaissance 4. Geneva: Droz, 2019. 840 pp. $106.80. Renaissance Qu
Creators: name: Chiodo, Carol
Publisher: name: Humanities Commons
Year: 2023
Subjects: subject: European poetry--Renaissance
subject: Italian literature
subject: Petrarchism
subject: Colonna, Vittoria, 1492-1547
subject: Sonnets, Italian
subject: Early printed books

description: Book review of Mikaël Romanato's critical edition of Gelosia del sole by Girolamo Britonio.
Additional file 1 of Biological and glucocorticoids treatment impair the medium-term immunogenicity to SARS-CoV-2 mRNA vaccines in autoimmune inflammatory rheumatic diseases
Creators: name: Garcia-Cirera, Silvia
name: Calvet, Joan
name: Delgado de la Poza, Juan Francisco
name: Berenguer-Llergo, Antoni
name: Orellana, Cristóbal
name: Rusiñol, Menna
name: Llop, Maria
name: Arévalo, Marta
name: Garcia-Pinilla, Alba
name: Costa, Ester
name: Aymerich, Cristina
name: Gómez, Rafael
name: Carreras, Anna
name: Gratacós, Jordi
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1: Figure S1. Anti-S protein antibodies titers by rheumatic disease groups before and after a third dose of mRNA-based SARSCoV-2 vaccine. Figure S2. Quantification of neutralizing antibodies for B.1.1.7 (Alpha) variant of SARS-CoV-2 by treatment regimen before and after a third dose of mRNA-based SARS-CoV-2 vaccine. Figure S3. Quantification of neutralizing antibodies for B.1.351 (Beta) variant of SARS-CoV-2 by treatment regimen before and after a third dose of mRNA-based SARS-CoV-2 vaccine. Figure S4. Quantification of neutralizing antibodies for B.1.617.2 (Delta) variant of SARS-CoV-2 by treatment regimen before and after a third dose of mRNA-based SARS-CoV-2 vaccine. Figure S5. Concordance of anti-S protein and neutralizing antibodies in pre-third dose samples. Figure S6. Concordance of anti-S protein and neutralizing antibodies in post-third dose samples.
Supplemental Material, PRISMA_2009_checklist - ENT Manifestations of Celiac Disease: A Scholarly Review
Creators: name: Karunaratne, Dilhara
name: Karunaratne, Nisal
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110315 Otorhinolaryngology
subject: FOS: Clinical medicine

description: Supplemental Material, PRISMA_2009_checklist for ENT Manifestations of Celiac Disease: A Scholarly Review by Dilhara Karunaratne and Nisal Karunaratne in Ear, Nose & Throat Journal
Exploring the Contraception Information Behaviors of Young Adults in Their 20s
Creators: name: O'Neal, Kaitlyn
Publisher: name: unknown
Year: 2023
Subjects: subject: Health--Information services
subject: Academic theses
subject: Contraception
subject: Information behavior

description: This dissertation focuses on the contraception information behaviors of young adults in their 20s in order to evaluate which factors cause this age group to identify an information need, what sources they use to conduct information searches, and how they decide when to end an information search. This dissertation met its research aims by conducting a thorough review of relevant studies alongside a survey. The research findings indicated that: (1) people in their 20s primarily want information about side effects and conduct their search mostly by consulting online medical sources or medical professionals, and (2) contraception information searches by people in their 20s are instigated by dissatisfaction with current contraceptive methods and are concluded when their specific questions have been answered. The main conclusions drawn from this research were that people in their 20s have specific contraception information needs different from those of younger age groups, that this age group views medically-associated information as both the most trustworthy and the most useful, and that although their information search is often frustrating, their information needs are still mostly satisfied. This dissertation recommends that more medically-associated information about contraceptive side effects should be readily available online to meet the needs of this age demographic, and that medical professionals should do more to support people in this age group in their search for contraception information.