BindingDB Entry 50019492: A decade of approved first-in-class small molecule orphan drugs: Achievements, challenges and perspectives.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: ALK tyrosine kinase receptor, Apoptosis regulator Bcl-2, B2 bradykinin receptor, BDNF/NT-3 growth factors receptor, Bile acid receptor, Cystic fibrosis transmembrane conductance regulator, Cytochrome P450 11B1, mitochondrial, Cytochrome P450 11B2, mitochondrial, Dual specificity mitogen-activated protein kinase kinase 1, Dual specificity mitogen-activated protein kinase kinase 2, Epidermal growth factor receptor, Exportin-1, Fibroblast growth factor receptor 1, Fibroblast growth factor receptor 2, Fibroblast growth factor receptor 3, GTPase HRas, GTPase KRas, Hepatocyte growth factor receptor, High affinity nerve growth factor receptor, Histamine H3 receptor, Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Isocitrate dehydrogenase [NADP], mitochondrial, Macrophage colony-stimulating factor 1 receptor, Mast/stem cell growth factor receptor Kit, Melanocortin receptor 4, Methionine synthase, NT-3 growth factor receptor, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Platelet-derived growth factor receptor alpha, Platelet-derived growth factor receptor beta, Poly [ADP-ribose] polymerase 1, Poly [ADP-ribose] polymerase 2, Receptor-type tyrosine-protein kinase FLT3, Serine/threonine-protein kinase B-raf, Transthyretin, Tryptophan 5-hydroxylase 1, Tyrosine-protein kinase BTK, Tyrosine-protein kinase JAK1, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase JAK3, Tyrosine-protein kinase SYK, Vascular endothelial growth factor receptor 1, Vascular endothelial growth factor receptor 2, and Vascular endothelial growth factor receptor 3, China Pharmaceutical University, Affinity

description: Small molecule binding data for protein ALK tyrosine kinase receptor, Apoptosis regulator Bcl-2, B2 bradykinin receptor, BDNF/NT-3 growth factors receptor, Bile acid receptor, Cystic fibrosis transmembrane conductance regulator, Cytochrome P450 11B1, mitochondrial, Cytochrome P450 11B2, mitochondrial, Dual specificity mitogen-activated protein kinase kinase 1, Dual specificity mitogen-activated protein kinase kinase 2, Epidermal growth factor receptor, Exportin-1, Fibroblast growth factor receptor 1, Fibroblast growth factor receptor 2, Fibroblast growth factor receptor 3, GTPase HRas, GTPase KRas, Hepatocyte growth factor receptor, High affinity nerve growth factor receptor, Histamine H3 receptor, Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Isocitrate dehydrogenase [NADP], mitochondrial, Macrophage colony-stimulating factor 1 receptor, Mast/stem cell growth factor receptor Kit, Melanocortin receptor 4, Methionine synthase, NT-3 growth factor receptor, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Platelet-derived growth factor receptor alpha, Platelet-derived growth factor receptor beta, Poly [ADP-ribose] polymerase 1, Poly [ADP-ribose] polymerase 2, Receptor-type tyrosine-protein kinase FLT3, Serine/threonine-protein kinase B-raf, Transthyretin, Tryptophan 5-hydroxylase 1, Tyrosine-protein kinase BTK, Tyrosine-protein kinase JAK1, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase JAK3, Tyrosine-protein kinase SYK, Vascular endothelial growth factor receptor 1, Vascular endothelial growth factor receptor 2, and Vascular endothelial growth factor receptor 3, Uniprot A0A024R759, O00329, O14980, O60674, P00533, P01112, P01116, P02766, P04629, P07333, P08581, P09619, P09874, P10415, P10721, P11362, P13569, P15056, P15538, P16234, P17752, P17948, P19099, P21802, P22607, P23458, P30411, P32245, P35916, P35968, P36507, P36888, P42336, P42338, P43405, P48735, P48736, P52333, P70596, Q02750, Q06187, Q15910, Q16288, Q16620, Q92800, Q96RI1, Q99707, Q9UGN5, Q9UM73, and Q9Y5N1