cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Out of equilibrium many-body expansion dynamics of strongly interacting bosons
Creators: name: Roy, Rhombik
name: Chakrabarti, Barnali
name: Gammal, Arnaldo
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We solve the Schrödinger equation from first principles to investigate the many-body effects in the expansion dynamics of one-dimensional repulsively interacting bosons released from a harmonic trap. We utilize the multiconfigurational time-dependent Hartree method for bosons (MCTDHB) to solve the many-body Schrödinger equation at high level of accuracy. The MCTDHB basis sets are explicitly time-dependent and optimised by variational principle. We probe the expansion dynamics by three key measures; time evolution of one-, two- and three-body densities. We observe when the mean-field theory results to unimodal expansion, the many-body calculation exhibits trimodal expansion dynamics. The many-body features how the initially fragmented bosons independently spreads out with time whereas the mean-field pictures the expansion of the whole cloud. We also present the three different time scale of dynamics of the inner core, outer core and the cloud as a whole. We analyze the key role played by the dynamical fragmentation during expansion. A Strong evidence of the many-body effects is presented in the dynamics of two- and three-body densities which exhibit correlation hole and pronounced delocalization effect.
description: 17 pages, 8 figures
Hijack Vertical Federated Learning Models As One Party
Creators: name: Qiu, Pengyu
name: Zhang, Xuhong
name: Ji, Shouling
name: Li, Changjiang
name: Pu, Yuwen
name: Yang, Xing
name: Wang, Ting
Publisher: name: arXiv
Year: 2022
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences

description: Vertical federated learning (VFL) is an emerging paradigm that enables collaborators to build machine learning models together in a distributed fashion. In general, these parties have a group of users in common but own different features. Existing VFL frameworks use cryptographic techniques to provide data privacy and security guarantees, leading to a line of works studying computing efficiency and fast implementation. However, the security of VFL's model remains underexplored.
description: https://doi.ieeecomputersociety.org/10.1109/TDSC.2024.3358081
Revisiting Boehmer et al. (2021): Recent Period, Alternative Method, Different Conclusions
Creators: name: Ardia, David
name: Aymard, Clément
name: Cenesizoglu, Tolga
Publisher: name: arXiv
Year: 2024
Subjects: subject: Trading and Market Microstructure (q-fin.TR)
subject: General Finance (q-fin.GN)
subject: FOS: Economics and business

description: We reassess Boehmer et al. (2021, BJZZ)'s seminal work on the predictive power of retail order imbalance (ROI) for future stock returns. First, we replicate their 2010-2015 analysis in the more recent 2016-2021 period. We find that the ROI's predictive power weakens significantly. Specifically, past ROI can no longer predict weekly returns on large-cap stocks, and the long-short strategy based on past ROI is no longer profitable. Second, we analyze the effect of using the alternative quote midpoint (QMP) method to identify and sign retail trades on their main conclusions. While the results based on the QMP method align with BJZZ's findings in 2010-2015, the two methods provide different conclusions in 2016-2021. Our study shows that BJZZ's original findings are sensitive to the sample period and the approach to identify ROIs.
title: Through the Green Briar
Creators: name: Watkinson, Geoff
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 2014

description: Through the Green Briar is a condensed version of a longer memoir that follows the narrator over the course of approximately a decade, beginning at the age of 16, as he tries to find meaning and purpose. The setting moves from New Jersey, where the narrator grows up, to New York, where he goes to college, and Virginia, where he ultimately moves. It's a coming-of-age story without a redemptive ending. The New Jersey coast is destroyed by Hurricane Sandy, and this destruction ultimately reflects the narrator's self-destruction over the course of the narrative. And yet, the narrator learns that it is destruction that ultimately leads to creation—both in the physical world and the emotional.
Pierre Hattu
Creators: name: Plouvain, Pierre-Antoine-Samuel-Joseph (1754-1832)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2017
Subjects: Officier de justice d'Ancien Régime

description: Source: http://www.sudoc.fr/080675700
description: Coverage: Parlement de Flandre
On the $\infty$-topos semantics of homotopy type theory
Creators: name: Riehl, Emily
Publisher: name: arXiv
Year: 2022
Subjects: subject: Category Theory (math.CT)
subject: Algebraic Topology (math.AT)
subject: Logic (math.LO)
subject: FOS: Mathematics
subject: 18N60, 18N45, 18N50, 03B38, 55U35

description: Many introductions to homotopy type theory and the univalence axiom gloss over the semantics of this new formal system in traditional set-based foundations. This expository article, written as lecture notes to accompany a 3-part mini course delivered at the Logic and Higher Structures workshop at CIRM-Luminy, attempts to survey the state of the art, first presenting Voevodsky's simplicial model of univalent foundations and then touring Shulman's vast generalization, which provides an interpretation of homotopy type theory with strict univalent universes in any $\infty$-topos. As we will explain, this achievement was the product of a community effort to abstract and streamline the original arguments as well as develop new lines of reasoning.
description: These lecture notes were written to accompany a mini-course delivered at CIRM - Luminy from 21-25 February 2022. Video is available at https://www.carmin.tv/en/collections/logic-and-higher-structures-logique-et-structures-superieures; v2 incorporates feedback from the referee; v3 is the final journal version with updated section numbers to conform to journal style
Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity
Creators: name: Tauro, Marilena
name: Laghezza, Antonio
name: Loiodice, Fulvio
name: Piemontese, Luca
name: Caradonna, Alessia
name: Capelli, Davide
name: Montanari, Roberta
name: Pochetti, Giorgio
name: Pizio, Antonella Di
name: Agamennone, Mariangela
name: Campestre, Cristina
name: Tortorella, Paolo
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: New catechol-containing chemical entities have been investigated as matrix metalloproteinase inhibitors as well as antioxidant molecules. The combination of the two properties could represent a useful feature due to the potential application in all the pathological processes characterized by increased proteolytic activity and radical oxygen species (ROS) production, such as inflammation and photoaging. A series of catechol-based molecules were synthesized and tested for both proteolytic and oxidative inhibitory activity, and the detailed binding mode was assessed by crystal structure determination of the complex between a catechol derivative and the matrix metalloproteinase-8. Surprisingly, X-ray structure reveals that the catechol oxygens do not coordinates the zinc atom.
Cosmic Reionization On Computers: Statistics, Physical Properties and Environment of Lyman Limit Systems at $z\sim6$
Creators: name: Fan, Jiawen
name: Zhu, Hanjue
name: Avestruz, Camille
name: Gnedin, Nickolay Y.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Lyman limit systems (LLSs) are dense hydrogen clouds with high enough HI column densities to absorb Lyman continuum photons emitted from distant quasars. Their high column densities imply an origin in dense environments; however, the statistics and distribution of LLSs at high redshifts still remain uncertain. In this paper, we use self-consistent radiative transfer cosmological simulations from the "Cosmic Reionization On Computers" (CROC) project to study the physical properties of LLSs at the tail end of cosmic reionization at $z\sim6$. We generate 3000 synthetic quasar sightlines to obtain a large number of LLS samples in the simulations. In addition, with the high physical fidelity and resolution of CROC, we are able to quantify the association between these LLS samples and nearby galaxies. Our results show that the fraction LLSs spatially associated with nearby galaxies is increasing with the HI column density. Moreover, we find that LLSs that are not near any galaxy typically reside in filamentary structures connecting neighboring galaxies in the intergalactic medium (IGM). This quantification of the distribution and associations of LLSs to large scale structures informs our understanding of the IGM-galaxy connection during the Epoch of Reionization, and provides a theoretical basis for interpreting future observations.
description: 11 pages, 10 figures, submitted to ApJ
Selective inhibition of human carbonic anhydrase IX in Xenopus oocytes and MDA-MB-231 breast cancer cells
Creators: name: Kazokaitė, Justina
name: Ames, Samantha
name: Becker, Holger M.
name: Deitmer, Joachim W.
name: Matulis, Daumantas
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Human carbonic anhydrase IX (CA IX) is overexpressed in the most aggressive and invasive tumors. Therefore, CA IX has become the promising antitumor drug target. Three inhibitors have been shown to selectively and with picomolar affinity inhibit human recombinant CA IX. Their inhibitory potencies were determined for the CA IX, CA II, CA IV and CA XII in Xenopus oocytes and MDA-MB-231 cancer cells. The inhibition IC50 value of microelectrode-monitored intracellular and extracellular acidification reached 15 nM for CA IX, but with no effect on CA II expressed in Xenopus oocytes. Results were confirmed by mass spectrometric gas analysis of lysed oocytes, when an inhibitory effect on CA IX catalytic activity was found after the injection of 1 nM VD11-4-2. Moreover, VD11-4-2 inhibited CA activity in MDA-MB-231 cancer cells at nanomolar concentrations. This combination of high selectivity and potency renders VD11-4-2, an auspicious therapeutic drug for target-specific tumor therapy.
title: Parbleu! Où est passé Caspar David?
title: Parbleu! Où est passé Caspar David?
titleType: AlternativeTitle
Creators: name: Singy, Géraldine
Publisher: name: Géraldine Singy
Year: 0

description: Récit raconté lors du vernissage de l’exposition « F comme … » du 8 mars 2016 au Centre Culturel de la Vidondée à Riddes, Suisse.
Homological dimensions of Burch ideals, submodules and quotients
Creators: name: Ghosh, Dipankar
name: Saha, Aniruddha
Publisher: name: arXiv
Year: 2022
Subjects: subject: Commutative Algebra (math.AC)
subject: FOS: Mathematics
subject: Primary 13C13, 13D05, 13D07, 13H10, 13B22

description: The notion of Burch ideals and Burch submodules were introduced (and studied) by Dao-Kobayashi-Takahashi in 2020 and Dey-Kobayashi in 2022 respectively. The aim of this article is to characterize various local rings in terms of homological invariants of Burch ideals, Burch submodules, or that of the corresponding quotients. Specific applications of our results include the following: Let $(R,\mathfrak{m})$ be a commutative Noetherian local ring. Let $M=I$ be an integrally closed ideal of $R$ such that ${\rm depth}(R/I)=0$, or $M = \mathfrak{m} N \neq 0$ for some submodule $N$ of a finitely generated $R$-module $L$ such that either ${\rm depth}(N)\ge 1$ or $L$ is free. It is shown that: (1) $I$ has maximal projective $($resp., injective$)$ complexity and curvature. (2) $R$ is Gorenstein if and only if ${\rm Ext}_R^n(M,R)=0$ for any three consecutive values of $n \ge \max\{{\rm depth}(R)-1,0\}$. (3) $R$ is CM (Cohen-Macaulay) if and only if CM-$\dim_R(M)$ is finite.
description: 14 pages, Journal of Pure and Applied Algebra (to appear), Revised version, Particularly added Remark 2.9 and its proof, and paragraph 4.9
title: 02_0267
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Affective bias in visual working memory is associated with capacity
Creators: name: Weizhen Xie
name: Huanhuan Li
name: Xiangyu Ying
name: Shiyou Zhu
name: Fu, Rong
name: Yingmin Zou
name: Yanyan Cui
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Neuroscience
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: How does the affective nature of task stimuli modulate working memory (WM)? This study investigates whether WM maintains emotional information in a biased manner to meet the motivational principle of approaching positivity and avoiding negativity by retaining more approach-related positive content over avoidance-related negative content. This bias may exist regardless of individual differences in WM functionality, as indexed by WM capacity (overall bias hypothesis). Alternatively, this bias may be contingent on WM capacity (capacity-based hypothesis), in which a better WM system may be more likely to reveal an adaptive bias. In two experiments, participants performed change localisation tasks with emotional and non-emotional stimuli to estimate the number of items that they could retain for each of those stimuli. Although participants did not seem to remember one type of emotional content (e.g. happy faces) better than the other type of emotional content (e.g. sad faces), there was a significant correlation between WM capacity and affective bias. Specifically, participants with higher WM capacity for non-emotional stimuli (colours or line-drawing symbols) tended to maintain more happy faces over sad faces. These findings demonstrated the presence of a “built-in” affective bias in WM as a function of its systematic limitations, favouring the capacity-based hypothesis.
title: Savez-vous qui est Luttowic Muvicdzvic ?
title: Savez-vous qui est Luttowic Muvicdzvic ?
titleType: AlternativeTitle
Creators: name: Singy, Géraldine
Publisher: name: Géraldine Singy
Year: 0

description: Performance réalisée lors de l’exposition « La Cimaise et la Fraction » à Urgent Paradise le 2 avril 2015. Des fragments de l’histoire inventée de ce cartographe sont racontés aux spectateurs lorsqu’ils s’approchent de l’installation tout en faisant croire à un fait historique.
Jupiter Subtractive Difference [of the Equation of Anomaly] - Ptolemy's Almagest by Toomer (Gerald J.) (1984) | Type-B (ID n° 359)
Creators: name: Toomer, Gerald J.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021
Subjects: Astronomy
Medieval history

description: This is a type B edition: A type-B edition corresponds to a critical edition of several table witnesses:
 it is based on several different editions, themselves based on tables from different primary sources.
 A type-B edition can be based on type-A, type-B or type-C editions.
You can find it on the DISHAS project website from this link: https://dishas.obspm.fr/table-edition/359
description: Source: Ptolemy's Almagest, Toomer (Gerald J.), 1984
title: 02_1268
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Hyperbolic Hierarchical Contrastive Hashing
Creators: name: Wei, Rukai
name: Liu, Yu
name: Song, Jingkuan
name: Xie, Yanzhao
name: Zhou, Ke
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Hierarchical semantic structures, naturally existing in real-world datasets, can assist in capturing the latent distribution of data to learn robust hash codes for retrieval systems. Although hierarchical semantic structures can be simply expressed by integrating semantically relevant data into a high-level taxon with coarser-grained semantics, the construction, embedding, and exploitation of the structures remain tricky for unsupervised hash learning. To tackle these problems, we propose a novel unsupervised hashing method named Hyperbolic Hierarchical Contrastive Hashing (HHCH). We propose to embed continuous hash codes into hyperbolic space for accurate semantic expression since embedding hierarchies in hyperbolic space generates less distortion than in hyper-sphere space and Euclidean space. In addition, we extend the K-Means algorithm to hyperbolic space and perform the proposed hierarchical hyperbolic K-Means algorithm to construct hierarchical semantic structures adaptively. To exploit the hierarchical semantic structures in hyperbolic space, we designed the hierarchical contrastive learning algorithm, including hierarchical instance-wise and hierarchical prototype-wise contrastive learning. Extensive experiments on four benchmark datasets demonstrate that the proposed method outperforms the state-of-the-art unsupervised hashing methods. Codes will be released.
description: 12 pages, 8 figures
Rainproof: An Umbrella To Shield Text Generators From Out-Of-Distribution Data
Creators: name: Darrin, Maxime
name: Piantanida, Pablo
name: Colombo, Pierre
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences

description: Implementing effective control mechanisms to ensure the proper functioning and security of deployed NLP models, from translation to chatbots, is essential. A key ingredient to ensure safe system behaviour is Out-Of-Distribution (OOD) detection, which aims to detect whether an input sample is statistically far from the training distribution. Although OOD detection is a widely covered topic in classification tasks, most methods rely on hidden features output by the encoder. In this work, we focus on leveraging soft-probabilities in a black-box framework, i.e. we can access the soft-predictions but not the internal states of the model. Our contributions include: (i) RAINPROOF a Relative informAItioN Projection OOD detection framework; and (ii) a more operational evaluation setting for OOD detection. Surprisingly, we find that OOD detection is not necessarily aligned with task-specific measures. The OOD detector may filter out samples well processed by the model and keep samples that are not, leading to weaker performance. Our results show that RAINPROOF provides OOD detection methods more aligned with task-specific performance metrics than traditional OOD detectors.
Spin-state ordering and intermediate states in the mixed-valence cobalt oxyborate Co$_3$O$_2$BO$_3$ with spin crossover
Creators: name: Granado, E.
name: Galdino, C. W.
name: Moreno, B. D.
name: King, G.
name: Freitas, D. C.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Spin-state ordering - a periodic pattern of ions with different spin-state configurations along a crystal lattice - is a rare phenomenon, and its possible interrelation with other electronic degrees of freedom remains little explored. Here we perform a structural investigation of the mixed-valence Co homometallic ludwigite Co$_2^{2+}$Co$^{3+}$O$_2$BO$_3$. A superstructure consistent with a long-range Co$^{3+}$ spin-state ordering is observed between $T_{4}=580$ K and $T_{3}=510$ K. Intermediate states with mesoscopic correlations are detected below $T_{3}$ down to $T_{1}=480$ K with a change of dimensionality at $T_{2}=495$ K. The spin-state correlations are connected to the charge sector as revealed by the abrupt changes in the electrical resistance at $T_1$ and $T_2$. The evolution of the structural parameters below $T_{1}$ indicate that the spin crossover is ignited by a moderate degree of thermally-induced Co$^{2+}$/Co$^{3+}$ charge disorder. Charge and spin-state degrees of freedom can be interrelated in mixed-valence spin-crossover materials, leading to sharp transitions involving intermediate spin-state/charge correlated states at the mesoscale.
description: 28 pages, 8 figures
Study of reactivity of cyanoacetohydrazonoethyl-N-ethyl-N-methyl benzenesulfonamide: preparation of novel anticancer and antimicrobial active heterocyclic benzenesulfonamide derivatives and their molecular docking against dihydrofolate reductase
Creators: name: Debbabi, Khaled F.
name: Al-Harbi, Sami A.
name: Al-Saidi, Hamed M.
name: Enas H. Aljuhani
name: Shimaa M. Abd El-Gilil
name: Bashandy, Mahmoud S.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: This article describes the synthesis of some novel heterocyclic sulfonamides having biologically active thiophene 3, 4, 5, 6, coumarin 8, benzocoumarin 9, thiazole 7, piperidine 10, pyrrolidine 11, pyrazole 14 and pyridine 12, 13. Starting with 4-(1-(2-(2-cyanoacetyl)hydrazono)ethyl)-N-ethyl-N-methylbenzenesulfonamide (2), which was prepared from condensation of acetophenone derivative 1 with 2-cyanoacetohydrazide. The structures of the newly synthesized compounds were confirmed by elemental analysis, IR, 1H NMR, 13C NMR, 19F NMR and MS spectral data. All the newly synthesized heterocyclic sulfonamides were evaluated as in-vitro anti-breast cancer cell line (MCF7) and as in-vitro antimicrobial agents. Compounds 8, 5 and 11 were more active than MTX reference drug and compounds 12, 7, 4, 14, 5 and 8 were highly potent against Klebsiella pneumonia. Molecular operating environment performed virtual screening using molecular docking studies of the synthesized compounds. The results indicated that some prepared compounds are suitable inhibitor against dihydrofolate reductase (DHFR) enzyme (PDBSD:4DFR) with further modification.
RIS-Assisted Receive Quadrature Spatial Modulation with Low-Complexity Greedy Detection
Creators: name: Dinan, Mohamad H.
name: Di Renzo, Marco
name: Flanagan, Mark F.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Information Theory (cs.IT)
subject: Signal Processing (eess.SP)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In this paper, we propose a novel reconfigurable intelligent surface (RIS)-assisted wireless communication scheme which uses the concept of spatial modulation, namely RIS-assisted receive quadrature spatial modulation (RIS-RQSM). In the proposed RIS-RQSM system, the information bits are conveyed via both the indices of the two selected receive antennas and the conventional in-phase/quadrature (IQ) modulation. We propose a novel methodology to adjust the phase shifts of the RIS elements in order to maximize the signal-to-noise ratio (SNR) and at the same time to construct two separate PAM symbols at the selected receive antennas, as the in-phase and quadrature components of the desired IQ symbol. An energy-based greedy detector (GD) is implemented at the receiver to efficiently detect the received signal with minimal channel state information (CSI) via the use of an appropriately designed one-tap pre-equalizer. We also derive a closed-form upper bound on the average bit error probability (ABEP) of the proposed RIS-RQSM system. Then, we formulate an optimization problem to minimize the ABEP in order to improve the performance of the system, which allows the GD to act as a near-optimal receiver. Extensive numerical results are provided to demonstrate the error rate performance of the system and to compare with that of a prominent benchmark scheme. The results verify the remarkable superiority of the proposed RIS-RQSM system over the benchmark scheme.
description: 30 pages (single column), 6 figures, 1 table
Morse numbers of function germs with isolated singularities
Creators: name: Maxim, Laurentiu
name: Tibăr, Mihai
Publisher: name: arXiv
Year: 2023
Subjects: subject: Complex Variables (math.CV)
subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: A set of Morse numbers is associated to a holomorphic function germ with stratified isolated singularity, extending the classical Milnor number to the setting of a singular base space.
description: 9 pages
Testing AGN outflow and accretion models with CIV and HeII emission line demographics in z=2 quasars
Creators: name: Temple, Matthew J.
name: Matthews, James H.
name: Hewett, Paul C.
name: Rankine, Amy L.
name: Richards, Gordon T.
name: Banerji, Manda
name: Ferland, Gary J.
name: Knigge, Christian
name: Stepney, Matthew
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Using 190,000 spectra from the seventeenth data release of the Sloan Digital Sky Survey, we investigate the ultraviolet emission line properties in z=2 quasars. Specifically, we quantify how the shape of CIV 1549A and the equivalent width (EW) of HeII 1640A depend on the black hole mass and Eddington ratio inferred from MgII 2800A. Above L/L_Edd>0.2, there is a strong mass dependence in both CIV blueshift and HeII EW. Large CIV blueshifts are observed only in regions with both high mass and high accretion rate. Including X-ray measurements for a subsample of 5,000 objects, we interpret our observations in the context of AGN accretion and outflow mechanisms. The observed trends in HeII and 2 keV strength are broadly consistent with theoretical QSOSED models of AGN spectral energy distributions (SEDs) for low spin black holes, where the ionizing SED depends on the accretion disc temperature and the strength of the soft excess. High spin models are not consistent with observations, suggesting SDSS quasars at z=2 may in general have low spins. We find a dramatic switch in behaviour at L/L_Edd<0.2: the ultraviolet emission properties show much weaker trends, and no longer agree with QSOSED predictions, hinting at changes in the structure of the broad line region. Overall the observed emission line trends are generally consistent with predictions for radiation line driving where quasar outflows are governed by the SED, which itself results from the accretion flow and hence depends on both the SMBH mass and accretion rate.
description: Resubmitted to MNRAS. Minor edits to text; figures updated; licence updated
High-Dimensional Mean-Variance Spanning Tests
Creators: name: Ardia, David
name: Laurent, Sébastien
name: Sessinou, Rosnel
Publisher: name: arXiv
Year: 2024
Subjects: subject: Methodology (stat.ME)
subject: General Finance (q-fin.GN)
subject: Portfolio Management (q-fin.PM)
subject: Statistical Finance (q-fin.ST)
subject: FOS: Computer and information sciences
subject: FOS: Economics and business

description: We introduce a new framework for the mean-variance spanning (MVS) hypothesis testing. The procedure can be applied to any test-asset dimension and only requires stationary asset returns and the number of benchmark assets to be smaller than the number of time periods. It involves individually testing moment conditions using a robust Student-t statistic based on the batch-mean method and combining the p-values using the Cauchy combination test. Simulations demonstrate the superior performance of the test compared to state-of-the-art approaches. For the empirical application, we look at the problem of domestic versus international diversification in equities. We find that the advantages of diversification are influenced by economic conditions and exhibit cross-country variation. We also highlight that the rejection of the MVS hypothesis originates from the potential to reduce variance within the domestic global minimum-variance portfolio.
Antifungal compound honokiol triggers oxidative stress responsive signalling pathway and modulates central carbon metabolism
Creators: name: Wang, Zhe
name: Shen, Yan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: The fast growing evidences have shown that the plant-derived compound honokiol is a promising candidate for treating multiple human diseases, such as inflammation and cancer. However, the mode-of-action (MoA) of honokiol remains largely unclear. Here, we studied the antifungal activity of honokiol in fission yeast model, with the goal of understanding the honokiol’s mechanism of action from the molecular level. We found that honokiol can inhibit the yeast growth at a dose-dependent way. Microarray analysis showed that honokiol has wide impacts on the fission yeast transcription levels (in total, 512 genes are up-regulated, and 42 genes are down-regulated). Gene set enrichment analysis indicated that over 45% up-regulated genes belong to the core environmental stress responses category. Moreover, network analysis suggested that there are extensive gene–gene interactions amongst the co-expression gene lists, which can assemble several biofunctionally important modules. It is noteworthy that several key components of central carbon metabolism, such as glucose transporters and metabolic enzymes of glycolysis, are involved in honokiol’s MoA. The complexity of the honokiol’s MoA displayed in previous studies and this work demonstrates that multiple omics approaches and bioinformatics tools should be applied together to achieve the complete scenario of honokiol’s antifungal function.
Best possible upper bounds on the restrained domination number of cubic graphs
Creators: name: Brešar, Boštjan
name: Henning, Michael A.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05C69

description: A dominating set in a graph $G$ is a set $S$ of vertices such that every vertex in $V(G) \setminus S$ is adjacent to a vertex in $S$. A restrained dominating set of $G$ is a dominating set $S$ with the additional restraint that the graph $G - S$ obtained by removing all vertices in $S$ is isolate-free. The domination number $γ(G)$ and the restrained domination number $γ_{r}(G)$ are the minimum cardinalities of a dominating set and restrained dominating set, respectively, of $G$. Let $G$ be a cubic graph of order~$n$. A classical result of Reed [Combin. Probab. Comput. 5 (1996), 277--295] states that $γ(G) \le \frac{3}{8}n$, and this bound is best possible. To determine a best possible upper bound on the restrained domination number of $G$ is more challenging, and we prove that $γ_{r}(G) \le \frac{2}{5}n$.
description: 39 pages, 16 figures
Exploring the potential of prototype-based soft-labels data distillation for imbalanced data classification
Creators: name: Rosu, Radu-Andrei
name: Breaban, Mihaela-Elena
name: Luchian, Henri
Publisher: name: arXiv
Year: 2024
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Dataset distillation aims at synthesizing a dataset by a small number of artificially generated data items, which, when used as training data, reproduce or approximate a machine learning (ML) model as if it were trained on the entire original dataset. Consequently, data distillation methods are usually tied to a specific ML algorithm. While recent literature deals mainly with distillation of large collections of images in the context of neural network models, tabular data distillation is much less represented and mainly focused on a theoretical perspective. The current paper explores the potential of a simple distillation technique previously proposed in the context of Less-than-one shot learning. The main goal is to push further the performance of prototype-based soft-labels distillation in terms of classification accuracy, by integrating optimization steps in the distillation process. The analysis is performed on real-world data sets with various degrees of imbalance. Experimental studies trace the capability of the method to distill the data, but also the opportunity to act as an augmentation method, i.e. to generate new data that is able to increase model accuracy when used in conjunction with - as opposed to instead of - the original data.
Mingling of the infrared and ultraviolet and the "cosmological constant" for interacting QFT in 2d
Creators: name: LeClair, André
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We propose a proper definition of the vacuum expectation value of the stress energy tensor $\langle 0 | T_{μν} |0 \rangle$ for integrable quantum field theories in two spacetime dimensions, which is the analog of the cosmological constant in 4d. For a wide variety of models, massive or massless, we show $ρ_{\rm vac} = - m^2/2 \mathfrak{g} $ exactly, where $\mathfrak{g} $ is a generalized coupling which we compute and $m$ is a basic mass scale. The kinds of models we consider are the massive sinh-Gordon and sine-Gordon theories and perturbations of the Yang-Lee and 3-state Potts models, pure $T\bar{T}$ perturbations of infra-red QFT's, and UV completions of the latter which are massless flows between UV and IR fixed points. In the massive case $m$ is the mass of the lightest particle and $\mathfrak{g} $ is related to parameters in the 2-body S-matrix. In some examples $ρ_{\rm vac} =0$ due to an unbroken fractional supersymmetry. For massless cases, $m$ can be a scale of spontaneous symmetry breaking. The "cosmological constant problem" generically arises in the free field limit $\mathfrak{g} \to 0$, thus interactions can potentially resolve the problem at least for most cases considered in this paper. We speculate on extensions of these results to 4 spacetime dimensions and propose $ρ_{\rm vac} =- m^4/2 \mathfrak{g}$,however without integrability we cannot yet propose a precise manner in which to calculate $\mathfrak{g}$. Nevertheless, based on cosmological data on $ρ_{\rm vac} $, if $\mathfrak{g} \approx 1$ then the lightest mass particle is on the order of experimental values of proposed neutrino masses.
description: 10 pages; version 2: The only change is our convention for the sign of the vacuum energy $\rho_{\rm vac}$, which is now more in line with standard 4d cosmology literature version3: We included the example of the sine-Gordon model which is very illustrative. Previous results didn't change. Version 4: published version in JHEP, primary change is added references
On the influence of external stochastic excitation on linear oscillators with subcritical self-excitation applied to brake squeal
Creators: name: Nguyen-Thai, Minh-Tuan
name: Wulff, Paul
name: Gräbner, Nils
name: Wagner, Utz Von
Publisher: name: Technische Universität Berlin
Year: 2019
Subjects: subject: 621 Angewandte Physik
subject: non-normality
subject: linear systems
subject: self-excitation
subject: brake squeal
subject: vibration
subject: noise
subject: external stochastic excitation
subject: EDKN system

description: A characteristic of linear systems with self-excitation is the occurrence of non-normal modes. Because of this non-normality, there may be a significant growth in the vibration amplitude at the beginning of the transient process even in the case of solely negative real parts of the eigenvalues, i.e. asymptotic stability of the trivial solution. If such a system is excited additionally with white noise, this process is continually restarted and a stationary vibration with dominating frequencies and comparably large amplitudes can be observed. Similar observations can be made during brake squeal, a high-frequency noise resulting from self-excitation due to the frictional disk-pad contact. Although commonly brake squeal is considered as a stable limit cycle with the necessity of corresponding nonlinearities, comparable noise phenomena can in the described model even observed in a pure linear case when the trivial solution is asymptotically stable.
Supplementary Material for: Assessing the Impact of Atopic Dermatitis on the Patients' Parents with the Visual Instrument ‘Caregiver-PRISM'
Creators: name: Marinello, E.
name: Linder, D.
name: Spoto, A.
name: Palmer, K.
name: Rohrer, P.M.
name: Büchi, S.
name: Trapp, M.
name: Trapp, E.-M.
name: Hoerlesberger, N.
name: Piaserico, S.
name: Peserico, A.
name: Gatta, M.
name: Belloni Fortina, A.
Publisher: name: Karger Publishers
Year: 2016
Subjects: Medicine

description: Background: There is a need to improve the quality of communication between clinicians and parents of young patients with atopic eczema (AE). Objective: To create a tool to measure the suffering that caregivers experience in association with their child's AE (Caregiver Pictorial Representation of Illness and Self-Measure, Caregiver-PRISM), assess the validity and reliability, and identify factors associated with caregiver suffering. Methods: Caregiver-PRISM was administered to 45 parents of patients from an AE outpatient service (Padua, Italy). Results: Caregiver-PRISM had a good test-retest reliability (r = 0.85; t7 = 4.13; p < 0.05), content validity and construct validity when used in parents of AE children. Parents with a less positive family affective climate, higher education, or with children following a diet experienced higher suffering associated with their child's AE, demonstrated by lower Caregiver-PRISM scores (p < 0.05). Conclusion: Our results support the use of Caregiver-PRISM in parents of AE patients to assess suffering associated with patients' illness.
Accuracy of software-assisted contour propagation from planning CT to cone beam CT in head and neck radiotherapy
Creators: name: Hvid, Christian A.
name: Elstrøm, Ulrik V.
name: Jensen, Kenneth
name: Alber, Markus
name: Grau, Cai
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Background: Autocontouring improves workflow in computed tomography (CT)-based dose planning, but could also potentially play a role for optimal use of daily cone beam CT (CBCT) in adaptive radiotherapy. This study aims to determine the accuracy of a deformable image registration (DIR) algorithm for organs at risk (OAR) in the neck region, when applied to CBCT. Material and methods: For 30 head and neck cancer (HNC) patients 14 OARs including parotid glands, swallowing structures and spinal cord were delineated. Contours were propagated by DIR from CT to the CBCTs of the first and last treatment fraction. An indirect approach, propagating contours to the first CBCT and from there to the last CBCT was also tested. Propagated contours were compared to manually corrected contours by Dice similarity coefficient (DSC) and Hausdorff distance (HD). Dose was recalculated on CBCTs and dosimetric consequences of uncertainties in DIR were reviewed. Results: Mean DSC values of ≥0.8 were considered adequate and were achieved in tongue base (0.91), esophagus (0.85), glottic (0.81) and supraglottic larynx (0.83), inferior pharyngeal constrictor muscle (0.84), spinal cord (0.89) and all salivary glands in the first CBCT. For the last CBCT by direct propagation, adequate DSC values were achieved for tongue base (0.85), esophagus (0.84), spinal cord (0.87) and all salivary glands. Using indirect propagation only tongue base (0.80) and parotid glands (0.87) were ≥0.8. Mean relative dose difference between automated and corrected contours was within ±2.5% of planed dose except for esophagus inlet (-4.5%) and esophagus (5.0%) for the last CBCT using indirect propagation. Conclusion: Compared to manually corrected contours, the DIR algorithm was accurate for use in CBCT images of HNC patients and the minor inaccuracies had little consequence for mean dose in most clinically relevant OAR. The method can thus enable a more automated segmentation of CBCT for use in adaptive radiotherapy.
Approximate higher-form symmetries, topological defects, and dynamical phase transitions
Creators: name: Armas, Jay
name: Jain, Akash
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: Higher-form symmetries are a valuable tool for classifying topological phases of matter. However, emergent higher-form symmetries in interacting many-body quantum systems are not typically exact due to the presence of topological defects. In this paper, we develop a systematic framework for building effective theories with approximate higher-form symmetries, i.e. higher-form symmetries that are weakly explicitly broken. We focus on a continuous U(1) q-form symmetry and study various patterns of symmetry breaking. This includes spontaneous or explicit breaking of higher-form symmetries, as well as pseudo-spontaneous symmetry breaking patterns where the higher-form symmetry is both spontaneously and explicitly broken. We uncover a web of dualities between such phases and highlight their role in describing the presence of dynamical higher-form vortices. In order to study the out-of-equilibrium dynamics of these phases of matter, we formulate respective hydrodynamic theories and study the spectra of excitations exhibiting higher-form charge relaxation and Goldstone relaxation effects. We show that our framework is able to describe various phase transitions due to proliferation of vortices or defects. This includes the melting transition in smectic crystals, the plasma phase transition from polarised gases to magnetohydrodynamics, the spin-ice transition, the superfluid to neutral fluid transition and the Meissner effect in superconductors, among many others.