cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Constraining the initial entropy of directly-detected exoplanets
Creators: name: Marleau, Gabriel-Dominique
name: Cumming, Andrew
Publisher: name: arXiv
Year: 2013
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The post-formation, initial entropy S_i of a gas giant planet is a key witness to its mass-assembly history and a crucial quantity for its early evolution. However, formation models are not yet able to predict reliably S_i, making unjustified the use solely of traditional, 'hot-start' cooling tracks to interpret direct imaging results and calling for an observational determination of initial entropies to guide formation scenarios. Using a grid of models in mass and entropy, we show how to place joint constraints on the mass and initial entropy of an object from its observed luminosity and age. This generalises the usual estimate of only a lower bound on the real mass through hot-start tracks. Moreover, we demonstrate that with mass information, e.g. from dynamical stability analyses or radial velocity, tighter bounds can be set on the initial entropy. We apply this procedure to 2M1207 b and find that its initial entropy is at least 9.2 kB/baryon, assuming that it does not burn deuterium. For the planets of the HR 8799 system, we infer that they must have formed with S_i > 9.2 kB/baryon, independent of uncertainties about the age of the star. Finally, a similar analysis for beta Pic b reveals that it must have formed with S_i > 10.5 kB/baryon, using the radial-velocity mass upper limit. These initial entropy values are respectively ca. 0.7, 0.5, and 1.5 kB/baryon higher than the ones obtained from core accretion models by Marley et al., thereby quantitatively ruling out the coldest starts for these objects and constraining warm starts, especially for beta Pic b.
description: 21 pages, 13 figures, 3 appendices. Important difference in SCvH entropies between various EOS versions discussed. Additions include: Analytic cooling curves for any S_i, appendix on radii, scaling with helium fraction. References added, updated and prettified direct-detection age--luminosity diagram. Conclusions unchanged. Matches published version
The Positive and Negative Economic Contributions of Mega-sporting Events to Local Communities
Creators: name: Gong, Qi
Publisher: name: University of Nevada, Las Vegas
Year: 2012

description: The purpose of this paper is to identify and examine the factors of mega-sporting events those contribute to positive economic impact as well as the factors that may negatively impact a community. Based on reviewing existing literature and data, the positive and negative contributions, a community may have through a hosting sporting event, will be discussed. The objective of this paper is focused on the economic impact that happened to the local communities.
Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics
Creators: name: Ratcliffe, P
name: Koivunen, P
name: Myllyharju, J
name: Ragoussis, J
name: Bovée, JVMG
name: Batinic-Haberle, I
name: Vinatier, C
name: Trichet, V
name: Robriquet, F
name: Oliver, L
name: Gardie, B
Publisher: name: The Francis Crick Institute
Year: 2021
Subjects: Biochemistry & Proteomics
Metabolism
Cell Biology
Signalling & Oncogenes

description: The "Hypoxia Nantes 2016" organized its second conference dedicated to the field of hypoxia research. This conference focused on "the role of hypoxia under physiological conditions as well as in cancer" and took place in Nantes, France, in October 6-7, 2016. The main objective of this conference was to bring together a large group of scientists from different spheres of hypoxia. Recent advances were presented and discussed around different topics: genomics, physiology, musculoskeletal, stem cells, microenvironment and cancer, and oxidative stress. This review summarizes the major highlights of the meeting.
Understanding Loyalty and Motivation of Professional Sports Fans
Creators: name: Wilkins, Victoria
Publisher: name: University of Nevada, Las Vegas
Year: 2012

description:  Purpose:  The purpose of this paper is to examine the factors which create continuous and permanent commitment to a specific professional sports team.
 Statement of Objectives:  There is no denying that the current economic standing of the United States does not promote spending large sums of money on entertainment and leisure. Since taking a family to a professional sports game gets rather expensive, families are lead to pursue other alternatives while deciding how to spend free time. The costs of game attendance, including tickets, parking, food, beverages and souvenirs, can easily surpass one hundred dollars, which is undoable for many individuals and families at this time. Long enduring fandom can still be achieved through television viewership, however it is more difficult to accomplish and measure. Without enduring fans, the business of professional sports would be unable to maintain its status as a multi-billion dollar industry. While discounted and lower cost tickets can be offered, the problem of how to offset an economic recession continuously arises.
 Justifications:  One cannot refute the massive impact professional sports have on the economy. It is therefore imperative to do everything one can to maintain the revenue generated by the sports industry, and this is done by creating and maintaining a withstanding fan base. Without these enduring fans attending games and purchasing team merchandise, the sports industry would flounder and perhaps not be able to survive, creating an even greater economic deficit which may not be offset by other industries. This paper will evaluate different factors which induce emotional responses in individuals that lead to lifelong fandom while accounting for varying levels of attachment one feels for a chosen team. This is done in order to present implications of the best practices to increase fan loyalty and incite future research throughout the professional sports industry.
Transparency and openness in science
Creators: name: Sanders, Jeremy
name: Blundy, Jon
name: Donaldson, Anne
name: Brown, Steve
name: Ivison, Rob
name: Padgett, Miles
name: Padian, Kevin
name: Rittinger, Katrin
name: Rowe, Kerry
name: Stace, Anthony
name: Viding, Essi
name: Chambers, Chris
name: Chaplain, Mark
Publisher: name: The Francis Crick Institute
Year: 2021
Subjects: subject: Biochemistry & Proteomics
subject: Signalling & Oncogenes
subject: Structural Biology & Biophysics
subject: Chemical Biology & High Throughput
subject: Infectious Disease
subject: Immunology
subject: FOS: Clinical medicine

description: No description supplied
Nanoparticle targeting of neutrophil improves cancer therapy
Creators: name: Shi, Xutong
Publisher: name: Washington State University
Year: 2018
Subjects: Cancer--Chemotherapy.
Nanoparticles--Therapeutic use
Neutrophils
Cancer--Chimiothérapie
Nanoparticules--Emploi en thérapeutique

description: In recent years, nanoparticle-based drug delivery systems have gained remarkable attention for cancer treatment since they can improve the safety of highly toxic anti-cancer agents. Conventionally, nanoparticles delivery of anticancer drugs to tumor tissues can be achieved by the enhanced permeability and retention effect. However, this passive mode of drug delivery has intrinsic limitations, such as tumor heterogeneity, that diminish tumor targeting specificity. A new concept has emerged, that of nanotherapeutics which selectively target immune cells to mediate drug delivery into tumors. This work focuses on a novel strategy to increase the delivery of nanotherapeutics to tumors by using neutrophils loaded with chemotherapeutics-containing nanoparticles to target photoactivatable tumors, and by taking advantage of the acidic microenvironment of tumors for selective pH-dependent drug release. The novel strategy we studied combines photodynamic therapy to stimulate inflammation around tumors and attract neutrophils charged with acid-pH sensitive, drug-containing, protein-based nanoparticles. Photodynamic therapy usually consists of three components: a photosensitizer, light and tissue oxygen. We proposed a novel approach by combining monoclonal antibody-photosensitizer conjugates and the laser light to induce inflammation in a tumor. For the targeted release of chemotherapeutic drugs, we designed a novel model of drug-containing nanoparticles in which the release of the drug is selectively activated by the acid microenvironment of tumors. This model was studied and validated using DOX-cis-BSA nanoparticles as prototypes. In DOX-cis-BSA nanoparticles, doxorubicin (DOX), a widely used chemotherapeutic agent, is attached to bovine serum albumin (BSA) via a pH-sensitive linker, cis-aconitic anhydride (cis). This linker readily hydrolyzes in the acidic tumoral environment, thus providing tumor-selective release of DOX. In summary, this thesis is aimed at developing a new type of nanoparticles that can be internalized by neutrophils to mediate the delivery of an anticancer drug to tumors after photodynamic therapy. Our work demonstrates that 1) inflammation can be successfully induced by laser-light in tumors labeled with tumor-specific monoclonal antibody-photosensitizer conjugates, and 2) acid-pH sensitive DOX-cis-BSA nanoparticles can be successfully synthesized. Our data provide feasibility evidence for the development of a novel delivery platform for chemotherapeutic drugs and suggest potential effectiveness of our new approach in cancer treatment.
Der römische Burgus in der Harlach bei Weißenburg i. B.
Creators: name: Winkelmann, Friedrich
Publisher: name: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts
Year: 2018

description: -
description: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts, Bd. 1, Nr. 2 (1917)
A Green Marketing Guideline for the Cruise Industry in North America
Creators: name: Guo, Xi
Publisher: name: University of Nevada, Las Vegas
Year: 2012

description:  Purpose:  The purpose of this professional paper is to develop a guideline of green marketing strategies for cruise managers in North America.
  Statement of objectives:  This paper will develop a customer relationship model according to the literature review of customer behavior and customer relationships in the hospitality industry. Meanwhile, the characteristics of green customers and the most popular green practices in the hotel and restaurant industry, and current sustainable achievements in the cruise industry will be investigated respectively. The green marketing guideline will be explored basing on the customer relationship model and the investigations of green customers and green practices from the literatures.
 Justification:  The number of serving cruise ships is increasing year by year. The annual cruise customer volume is also keep growing in recent years. The cruise industry has put much more pressure on global environment than before. Cruise managers have realized this problem and try to carry out all kinds of green practices to minimize cruise ships'negative influences on local environment. It is necessary to know what green practices should be developed and how to develop. Moreover, cruise managers need an effective advertising method to announce achievements of green practices to public and more potential cruise customers. By conducting green marketing strategy, cruise companies can build valuable green reputation and brand image. In other words, a good green marketing strategy can help a cruise company to be a winner in the violent marketing competition.
Ny Vise om de tre bortrømte Slaver
Creators: name: (:Unas)
Publisher: name: G.B. Strøm
Year: 0
Subjects: Fengselsstraff
Nyheter
Slaveri
Forbrytelser

description: Førstelinje: Aa faa Fæstningsstraf er nok lit leit, san.
description: Innhold: 12 vers, på 2 blad.
description: Melodi: [Jæ' sku' au ha Lyst te gjifte mei, san]
description: Innhold: [1] Ny Vise om de tre bortrømte Slaver. [2] Wermelandsvisan.
The Force of a Tsunami on a Wave Energy Converter
Creators: name: O'Brien, Laura
name: Christodoulides, Paul
name: Renzi, Emiliano
name: Dutykh, Denys
name: Dias, Frédéric
Publisher: name: arXiv
Year: 2012
Subjects: subject: Atmospheric and Oceanic Physics (physics.ao-ph)
subject: Classical Physics (physics.class-ph)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: With an increasing emphasis on renewable energy resources, wave power technology is fast becoming a realistic solution. However, the recent tsunami in Japan was a harsh reminder of the ferocity of the ocean. It is known that tsunamis are nearly undetectable in the open ocean but as the wave approaches the shore its energy is compressed creating large destructive waves. The question posed here is whether a nearshore wave energy converter (WEC) could withstand the force of an incoming tsunami. The analytical 3D model of Renzi & Dias (2012) developed within the framework of a linear theory and applied to an array of fixed plates is used. The time derivative of the velocity potential allows the hydrodynamic force to be calculated.
description: 12 pages, 6 figures, 2 tables, 16 references. Paper presented at the ISOPE-2012 conference. Other author's papers can be downloaded at http://www.lama.univ-savoie.fr/~dutykh/
Modeling passive solar distillation production in Las Vegas, Nevada
Creators: name: Santos, Noe I.
Publisher: name: University of Nevada, Las Vegas
Year: 2011

description: A study has been performed to examine the effects of daily weather on the performance of commercial solar distillation basins (solar stills). The objectives of this study were to evaluate the long term performance of solar stills, to instrument two solar stills and record sub-hourly thermal properties, to evaluate existing heat transfer modeling methods for hourly production, and to create new models to predict daily production using experimental distillate production and local weather data by utilizing artificial neural networks, genetic algorithms, and multivariate regression. A system dynamics model was also created to determine the required basin area and storage volume to produce enough water to meet year round potable water demand.
Solar still production was measured between January 2011 and September 2011. The average daily yield of solar still #1-A (SS1-A) and solar still #1-B (SS1-B) ranged from 2.11 ± 0.35 L/m2 and 2.00 ± 0.46 L/m2 (winter season) to 5.53 ± 1.01 L/m 2 and 5.64 ± 1.06 L/m2 (summer season), respectively.
The artificial neural network model performed with a mean absolute error as low as 9.4% with up to 92.4% of production predictions within 0-20% of the actual daily production. The genetic algorithm model performed with a mean absolute error as low as 11% with up to 91% of production predictions within 0-20% of the actual daily production. The multivariate regression model performed with a mean absolute error as low as 9.7% with up to 94.1% of production predictions within 0-20% of the actual daily production.
Analysis of the sub-hourly performance data indicated that large distilland volumes resulted in a greater proportion of production occurring during the night compared to smaller distilland volumes. Hourly temperature data was used to calculate heat transfer coefficients which could predict hourly distillate production with a mean absolute error between 26% and 53%.
Multi-Epoch Observations of the Redwing Excess in the Spectrum of 3C279
Creators: name: Punsly, Brian
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: It has been previously determined that there is a highly significant correlation between the spectral index from 10 GHz to 1350 $Å$ and the amount of excess luminosity in the red wing of quasar CIV $λ$1549 broad emission lines (BELs). Ostensibly, the prominence of the red excess is associated with the radio jet emission mechanism and is most pronounced for lines of sight close to the jet axis. Studying the scant significant differences in the UV spectra of radio loud and radio quiet quasars might provide vital clues to the origin of the unknown process that creates powerful relativistic jets that appear in only about ten percent of quasars. In this study, the phenomenon is explored with multi-epoch observations of the MgII $λ$2798 broad line in 3C 279 which has one of the largest known redwing excesses in a quasar spectrum. The amount of excess that is detected appears to be independent of all directly observed optical continuum, radio or submm properties (fluxes or polarizations). The only trend that occurs in this sparse data is: the stronger the BEL, the larger the fraction of flux that resides in the redwing. It is concluded that more monitoring is needed and spectropolarimetry with a large telescope is essential during low states to understand more.
description: To appear in ApJ Letters
En ny Vise om "Løven", et græsseligt Jertegn, der viste sig første Gang 2den Juledag 1847, og har siden jevnlig været seet af mange sandfærdige Mennesker, samt mangfoldige Flere
Creators: name: (:Unas)
Publisher: name: F. Steens, Trykkeri: F. Steens, Christiania
Year: 0
Subjects: Nyheter
Overtro
Dyr

description: Førstelinje: En Søorm der fordum fæl opsteg.
description: Innhold: 8 vers, på 2 blad.
description: Melodi: "Min Søn om du vil i Verden frem, saa buk"
Late Cenozoic geomorphic history of Lee Canyon, Spring Mountains, Nevada
Creators: name: Gucwa, John Henry
Publisher: name: University of Nevada, Las Vegas
Year: 1969

description: Located in the west central portion of Clark County, Nevada, the Spring Mountain Range borders the western edge of the Las Vegas Valley. Within the mountain range, a fault block, there are several canyons whose geomorphic history is closely related to the geomorphic history of the major alluvial fans which flank the mountains. Lee Canyon, which is the study area is one of these canyons. In Lee Canyon is preserved a complex canyon fill which has been subjected to several periods of down-cutting and valley-widening. The details of the canyon 's geomorphic history recorded by filling and fill removal has not previously been studied.
Trust in Transitional Market: Towards a dynamic and contextualised understanding of trust development in Chinese marketing channel relationship
Creators: name: Zheng, Tiantian
Publisher: name: University of Leicester
Year: 2021
Subjects: Uncategorized

description: This thesis aims to understand how trust development between business actors of marketing channel relationships is influenced by the dynamic socio-economic context of Chinese transitional economy. The rationale of this thesis lies in the belief that, in the Chinese transitional economy ⎯ where socio-economic conditions change over time ⎯ the recognition and comprehension of the nexus between trust development and socio-economic context can make all the difference to academic and practical understanding of why trust is successfully developed and sustained under certain socio-economic conditions of transitional economy, whilst being disrupted or broken under other conditions.This thesis transcends the conventional business-to-business marketing idea that trust is merely a static psychological belief. Instead, it views trust as a reflexive developing process that constitutes the cognitive, emotive and behavioural aspects of social experiences and situates trust development into business actors’ interaction experiences. The thesis also adopts the notion of embeddedness to examine how cultural, cognitive, social, and political conditions of Chinese transitional economy (re)shape economic actions and mentalities.The thesis develops a qualitative research design that combines a series of semi-structured interviews and participant observations. The empirical data confirms that business actors refer to their knowledge of socio-economic conditions when forming up the cognition, emotion and actions in their business interactions. As a result, the trust-developing process varies when business actors’ social knowledge evolves in concordance with the changing socio-economic conditions.The thesis also provides evidence that the constant struggle of power between free market and authoritarian government is the source of disruption to trust development in the Chinese transitional economy. Three mechanisms are found to offset the disruption: strong obligations to social norms; business-state ties; and obligations to formal control mechanisms. These mechanisms provide business actors with relatively stable reference systems that can be used to govern business interactions.
En splinter ny Vise, om Smedesønnen i Kristiania som kom til Verden med Salut paa Kongens Geburtsdag
Creators: name: (:Unas)
Publisher: name: G.B. Strøm
Year: 0
Subjects: Humor
Monarki

description: Førstelinje: Bort i Akersgaden bor en Mand, san.
description: Innhold: 5 vers, på 2 blad.
description: Melodi: [Jæ' sku' au ha Lyst te gjifte mei, san]
description: Innhold: [1] En splinter ny Vise, om Smedesønnen i Kristiania som kom til Verden med Salut paa Kongens Geburtsdag. [2] Bonden der kom til Kjøbenhavn med Torv. [3] En Spaavise.
It Takes Two to Tango: When and Where Dual Nutrient (N & P) Reductions Are Needed to Protect Lakes and Downstream Ecosystems
Creators: name: Havens, Karl E.
name: Wilhelm, Steven W.
name: Scott, J. Thad
name: Hoffman, Daniel K.
name: Paerl, Hans W.
name: Gardner, Wayne S.
name: Newell, Silvia E.
name: McCarthy, Mark J.
name: Wurtsbaugh, Wayne A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Preventing harmful algal blooms (HABs) is needed to protect lakes and downstream ecosystems. Traditionally, reducing phosphorus (P) inputs was the prescribed solution for lakes, based on the assumption that P universally limits HAB formation. Reduction of P inputs has decreased HABs in many lakes, but was not successful in others. Thus, the "P-only" paradigm is overgeneralized. Whole-lake experiments indicate that HABs are often stimulated more by combined P and nitrogen (N) enrichment rather than N or P alone, indicating that the dynamics of both nutrients are important for HAB control. The changing paradigm from P-only to consideration of dual nutrient control is supported by studies indicating that (1) biological N fixation cannot always meet lake ecosystem N needs, and (2) that anthropogenic N and P loading has increased dramatically in recent decades. Sediment P accumulation supports long-term internal loading, while N may escape via denitrification, leading to perpetual N deficits. Hence, controlling both N and P inputs will help control HABs in some lakes and also reduce N export to downstream N-sensitive ecosystems. Managers should consider whether balanced control of N and P will most effectively reduce HABs along the freshwater-marine continuum.
Radial propagation in population dynamics with density-dependent diffusion
Creators: name: Ngamsaad, Waipot
Publisher: name: arXiv
Year: 2013
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Populations and Evolution (q-bio.PE)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: The population dynamics that evolves in the radial symmetric geometry is investigated. The nonlinear reaction-diffusion model, which depends on population density, is employed as the governing equation for this system. The approximate analytical solution to this equation has been found. It shows that the population density evolves from initial state and propagates as the traveling wave-like for the large time scale. One can be mentioned that, if the distance is insufficient large, the curvature has ineluctable influence on density profile and front speed. In comparison, the analytical solution is in agreement with the numerical solution.
description: 4 pages, 2 figures, major revision
En Spaavise
Creators: name: [Bøgh, Erik]
Publisher: name: G.B. Strøm
Year: 0
Subjects: Humor
Overtro

description: Førstelinje: Min Moder, medens jeg var lille.
description: Innhold: 4 vers, på 2 blad.
description: Innhold: [1] En splinter ny Vise, om Smedesønnen i Kristiania som kom til Verden med Salut paa Kongens Geburtsdag. [2] Bonden der kom til Kjøbenhavn med Torv. [3] En Spaavise.
Resolving multiple supermassive black hole binaries with pulsar timing arrays II: genetic algorithm implementation
Creators: name: Petiteau, Antoine
name: Babak, Stanislav
name: Sesana, Alberto
name: de Araujo, Mariana
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Pulsar timing arrays (PTAs) might detect gravitational waves (GWs) from massive black hole (MBH) binaries within this decade. The signal is expected to be an incoherent superposition of several nearly-monochromatic waves of different strength. The brightest sources might be individually resolved, and the overall deconvolved, at least partially, in its individual components. In this paper we extend the maximum-likelihood based method developed in Babak & Sesana 2012, to search for individual MBH binaries in PTA data. We model the signal as a collection of circular monochromatic binaries, each characterized by three free parameters: two angles defining the sky location, and the frequency. We marginalize over all other source parameters and we apply an efficient multi-search genetic algorithm to maximize the likelihood function and look for sources in synthetic datasets. On datasets characterized by white Gaussian noise plus few injected sources with signal-to-noise ratio (SNR) in the range 10-60, our search algorithm performs well, recovering all the injections with no false positives. Individual source SNRs are estimated within few % of the injected values, sky locations are recovered within few degrees, and frequencies are determined with sub-Fourier bin precision.
description: 12 pages, 4 figures, 1 table; submitted to Physical Review D
Bonden der kom til Kjøbenhavn med Torv
Creators: name: (:Unas)
Publisher: name: G.B. Strøm
Year: 0
Subjects: Bønder
Politikk

description: Førstelinje: Nei, aldrig i mine levfødte Dage.
description: Innhold: 7 vers, på 2 blad.
description: Innhold: [1] En splinter ny Vise, om Smedesønnen i Kristiania som kom til Verden med Salut paa Kongens Geburtsdag. [2] Bonden der kom til Kjøbenhavn med Torv. [3] En Spaavise.
Additional file 2 of Adoption of C-reactive protein point-of-care tests for the management of acute childhood infections in primary care in the Netherlands and England: a comparative health systems analysis
Creators: name: Dewez, Juan Emmanuel
name: Nijman, Ruud G.
name: Fitchett, Elizabeth J. A.
name: Lynch, Rebecca
name: de Groot, Ronald
name: van der Flier, Michiel
name: Philipsen, Ria
name: Vreugdenhil, Harriet
name: Ettelt, Stefanie
name: Yeung, Shunmay
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2.
En ny og meget fornøielig Vise om Mødet paa Rasmussalen eller Kommunismen i Krestian
Creators: name: (:Unas)
Publisher: name: G.B. Strøm
Year: 0
Subjects: Humor
Politikk
Klasse
Nyheter

description: Førstelinje: Men er det da inte ei græsselig Ti.
description: Innhold: 14 vers, på 2 blad.
description: Melodi: [Ta i aa dra]
description: Visen handler om det første møtet til Den norske Arbeiderforening,avholdt i Rasmussalen på Grønland i september 1873.
The potential consequences for cancer care and cancer research of Brexit
Creators: name: Selby, Peter
name: Lawler, Mark
name: Baird, Richard
name: Banks, Ian
name: Johnston, Patrick
name: Nurse, Paul
Publisher: name: The Francis Crick Institute
Year: 2021
Subjects: Model organisms
Biochemistry & Proteomics
Synthetic Biology
Genetics & Genomics
Cell Biology
Cell Cycle & Chromosomes
Chemical Biology & High Throughput
Computational & Systems Biology

description: Following the UK "Brexit" vote in June 2016, there are many uncertainties and risks for cancer research and cancer care in the UK. These are summarised and the importance of sustained engagement and influence from the cancer community on UK governments is emphasised.
Temperature Resistant Optimal Ratchet Transport
Creators: name: Manchein, Cesar
name: Celestino, Alan
name: Beims, Marcus W
Publisher: name: arXiv
Year: 2012
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: Stable periodic structures containing optimal ratchet transport, recently found in the parameter space dissipation versus ratchet parameter [PRL 106, 234101 (2011)], are shown to be resistant to reasonable temperatures, reinforcing the expectation that they are essential to explain the optimal ratchet transport in nature. Critical temperatures for their destruction, valid from the overdamping to close to the conservative limits, are obtained numerically and shown to be connected to the current efficiency, given here analytically. Results are demonstrated for a discrete ratchet model and generalized to the Langevin equation with an additional external oscillating force.
description: 4 pages, 3 figs
Interaction induced mergence of Dirac points in Non-Abelian optical lattices
Creators: name: Wang, Li
name: Fu, Libin
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We study the properties of an ultracold Fermi gas loaded in a square optical lattice and subjected to an external and classical non-Abelian gauge field. We calculate the energy spectrum of the system and show that the Dirac points in the energy spectrum will remain quite stable under onsite interaction of certain strength. Once the on-site interaction grows stronger than a critical value, the Dirac points will no longer be stable and merge into a single hybrid point. This mergence implies a quantum phase transition from a semimetallic phase to a band insulator. The on-site interaction between ultracold fermions could be conveniently controlled by Feshbach resonances in current experiments. We proposed that this remarkable interaction induced mergence of Dirac points may be observed in the ultracold fermi gas experiments.
Macrophage-microbe interactions: Lessons from the Zebrafish model
Creators: name: Yoshida, N
name: Frickel, EM
name: Mostowy, S
Publisher: name: The Francis Crick Institute
Year: 2021
Subjects: subject: Model organisms
subject: Infectious Disease
subject: Immunology
subject: FOS: Clinical medicine
subject: Cell Biology

description: Macrophages provide front line defense against infections. The study of macrophage-microbe interplay is thus crucial for understanding pathogenesis and infection control. Zebrafish (Danio rerio) larvae provide a unique platform to study macrophage-microbe interactions in vivo, from the level of the single cell to the whole organism. Studies using zebrafish allow non-invasive, real-time visualization of macrophage recruitment and phagocytosis. Furthermore, the chemical and genetic tractability of zebrafish has been central to decipher the complex role of macrophages during infection. Here, we discuss the latest developments using zebrafish models of bacterial and fungal infection. We also review novel aspects of macrophage biology revealed by zebrafish, which can potentiate development of new therapeutic strategies for humans.
Forunderlige Tildragelser, forestillet i En Vise om en fornem, rig Kjøbmands-Datter, som blev forelsket i en fattig Matros, og deres haarde Skjebnes lykkelige Udfald
Creators: name: (:Unas)
Publisher: name: F. Steens Enke
Year: 0
Subjects: Kjærlighet
Økonomi
Klasse

description: Førstelinje: Enhver som vil vide hvad Kjærlighed er.
description: Innhold: 50 vers, på 4 blad.
description: Melodi: Hvad vindes paa Verdens det vildsomme Hav
En ny Vise om Den rige Herremand og den smukke Bærplukkerske
Creators: name: (:Unas)
Publisher: name: Trykkeri: H.J. Jensen, [Kristiania]
Year: 0
Subjects: Kjærlighet
Økonomi
Klasse
Kjønn

description: Førstelinje: En Herremand saa rig og bold.
description: Innhold: 14 vers, på 2 blad.
description: Melodi: Kan synges til 2de smukke Melodier
Additional file 1 of No need for a gold-standard test: on the mining of diagnostic test performance indices merely based on the distribution of the test value
Creators: name: Habibzadeh, Farrokh
name: Roozbehi, Hooman
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Additional file 1: Figure 1. Optimal number of clusters derived from fviz_nbclust. The vertical dashed line corresponds to the optimal number of clusters, here 2.
En spliterny og saare fornøielig Vise om Monitoren Mjølner, samt om det mærkværdige Østersslag ved Kragerø
Creators: name: (:Unas)
Publisher: name: G.B. Strøm
Year: 0
Subjects: Nyheter
Humor

description: Førstelinje: Hr. Burckardt saa hed Manden.
description: Innhold: 13 vers, på 2 blad.
description: Melodi: Adjø min søde Pige o. s. v.
Optimal correction of independent and correlated errors
Creators: name: Jacobsen, Sol H.
name: Mintert, Florian
Publisher: name: arXiv
Year: 2013
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We identify optimal quantum error correction codes for situations that do not admit perfect correction. We provide analytic n-qubit results for standard cases with correlated errors on multiple qubits and demonstrate significant improvements to the fidelity bounds and optimal entanglement decay profiles.
description: 11 pages, 4 figures. Updated to include fidelity analysis
Mitigation of smoke taint in wine
Creators: name: Gitsov, Ioan  Pavel Ivanov
Publisher: name: Washington State University
Year: 2019
Subjects: Wine adulteration--Prevention
Smoke

description: Grapevines that have been exposed to smoke have higher concentrations of methoxyphenols, due to degradation of lignin upon the burning of plant material. These methoxyphenols are responsible for smoky aromas and flavors and are present as free compounds and bound glycosylated forms. Upon fermentation of impacted fruit, these compounds are extracted and carried over into the finished wine. This phenomenon has a severe impact on wine sensory characteristics, and in turn, on reputations of established wineries and vineyards. In this study, methods for remediation of the free and bound smoke-related compounds were explored. Using gas-chromatography mass-spectrometry, reverse osmosis coupled with adsorption using activated carbon was successful in reducing the peak areas of phenol, 2,6-dimethylphenol, 2-ethyl-4-methylphenol, 2-ethyl-6-methylphenol, syringol, eugenol, and trans-isoeugenol in one treatment of research smoked Merlot wine, but surprisingly, not in the second. Furthermore, treatment of a commercial wine that was exposed to uncontrolled smoke application showed reductions in peak areas for different compounds, as expected, since the conditions of smoke application play a role in which compounds are present. Though it was not analyzed, it is imperative to also monitor beneficial aroma compounds present in the wine when treating smoke tainted wines, due to the low specificity of activated carbon. Enzymatic hydrolysis as a method for reducing the bound fraction of smoke compounds was also explored. Using a collection of ten enzymes with varying glycosidase, peroxidase, and pectinase activities, smoked and unsmoked permeate fractions were treated. Efficacy of treatment was determined using ultra-high pressure liquid chromatography-quadrupole time of flight-mass spectrometry to monitor peak areas for five bound compounds and five free compounds of interest. Of the ten enzymes analyzed, AR2000, Scottzyme BG, and Lallzyme Beta were found to be the most successful in liberating bound compounds following a 2h treatment time. As these three enzymes are a cocktail of enzymatic activities, advertised as pectinases with glycosidase and esterase side activities, future work should be carried out to determine which enzyme is primarily responsible for hydrolysis. Since these enzymes are readily used in the wine industry, however, implementation for treatment of smoke tainted wines is easy and inexpensive.
Understanding frailty, falls and the role of exercise in haemodialysis patients
Creators: name: Young, Hannah Mary Louise
Publisher: name: University of Leicester
Year: 2021
Subjects: Uncategorized

description: Frailty is highly prevalent in haemodialysis (HD) patients, leading to a range of poor outcomes. Intradialytic cycling (IDC) is the predominant form of rehabilitation offered, but may not be suited to those who are frail. This thesis aimed to determine whether a randomised controlled trial (RCT) of IDC is feasible for frail HD patients and inform a tailored exercise intervention for this population.Chapter 1 provides an overview of frailty and the potential role of exercise in an HD population.A systematic review (Chapter 2) investigating the effectiveness of IDC on exercise capacity, quality of life and physical function found that equipoise regarding the effects of IDC exists. Trials focusing specifically upon frail HD patients were also lacking, underlining the need for a feasibility RCT.A co-production process used to develop the progression criteria for the feasibility study is described in Chapter 3.Chapter 4 established some recommendations for the measurement of physical activity in HD patients which are used in the feasibility trial described in Chapter 7.The trial results (Chapter 7) indicated that, whilst a future definitive trial of IDC appears to be feasible for frail HD patients, adaptations are required to increase eligibility and outcome acceptability.The qualitative results (Chapter 8) identified several ways that a future trial could be adapted to enhance recruitment, outcome completion and reduce withdrawals. Whilst IDC was convenient, participants preferred a programme which included exercise preparation and offered choice, supervision, companionship and individualised progression.The original contributions within this thesis will help improve the conduct of future studies. The thesis also includes the first study to report that an RCT of IDC is feasible for frail HD patients and to outline how an exercise intervention and the design of a future definitive trial should be tailored to the needs of this group.
Simultaneous enhancement in gamma.gamma, b.b-bar and tau+.tau- rates in the NMSSM with nearly degenerate scalar and pseudoscalar Higgs bosons
Creators: name: Munir, Shoaib
name: Roszkowski, Leszek
name: Trojanowski, Sebastian
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We propose an experimental test of a scenario in the Next-to-Minimal Supersymmetric Standard Model in which both the lightest scalar and the lightest pseudoscalar Higgs bosons have masses around 125 GeV. The pseudoscalar can contribute significantly to the gamma.gamma rate at the LHC due to light Higgsino-like charginos in its effective one-loop coupling to two photons. Such charginos are obtained for small values of the mu_eff parameter which also results in enhanced b.b-bar and tau+.tau- rates compared to those expected for a Standard Model Higgs boson. This scenario should result in a clear discrepancy between the observed rates in these three decay channels and those in the WW and ZZ channels, since the pseudoscalar does not couple to the W and Z bosons. However, in the dominant gluon fusion production mode the pseudoscalar will stay hidden behind the SM-like scalar Higgs boson and in order for it to be observable the associated b.b-bar.h production mode has to be considered, the cross section for which is tiny in the Standard Model but tan.beta-enhanced in supersymmetry. We analyze the constrained NMSSM with non-universal Higgs sector parameters and identify regions of its parameter space where the lightest pseudoscalar with mass around 125 GeV and strongly enhanced gamma.gamma (up to 60%), b.b-bar and tau+.tau- rates in the b.b-bar.h mode can be obtained.
description: 23 pages, 6 figures. Improved discussion. Version published in PRD
Antibodies and tuberculosis
Creators: name: Jacobs, Ashley J
name: Mongkolsapaya, Juthathip
name: Screaton, Gavin R
name: McShane, Helen
name: Wilkinson, Robert J
Publisher: name: The Francis Crick Institute
Year: 2021
Subjects: subject: Model organisms
subject: Infectious Disease
subject: Human Biology & Physiology
subject: Immunology
subject: FOS: Clinical medicine

description: Tuberculosis (TB) remains a major public health problem internationally, causing 9.6 million new cases and 1.5 million deaths worldwide in 2014. The Bacillus Calmette-Guérin vaccine is the only licensed vaccine against TB, but its protective effect does not extend to controlling the development of infectious pulmonary disease in adults. The development of a more effective vaccine against TB is therefore a pressing need for global health. Although it is established that cell-mediated immunity is necessary for the control of latent infection, the presupposition that such immunity is sufficient for vaccine-induced protection has recently been challenged. A greater understanding of protective immunity against TB is required to guide future vaccine strategies against TB. In contrast to cell-mediated immunity, the human antibody response against M.tb is conventionally thought to exert little immune control over the course of infection. Humoral responses are prominent during active TB disease, and have even been postulated to contribute to immunopathology. However, there is evidence to suggest that specific antibodies may limit the dissemination of M.tb, and potentially also play a role in prevention of infection via mucosal immunity. Further, antibodies are now understood to confer protection against a range of intracellular pathogens by modulating immunity via Fc-receptor mediated phagocytosis. In this review, we will explore the evidence that antibody-mediated immunity could be reconsidered in the search for new vaccine strategies against TB.
At Slyngler hæves til Ærens Top
Creators: name: [Zetlitz, Jens]
Publisher: name: G.B. Strøm
Year: 0
Subjects: Moral

description: Førstelinje: At Slyngler hæves til Ærens Top.
description: Innhold: 5 vers.
description: Melodi: Bekjendt Melodi
Ny Vise om Jernbanemoroen ved Mjøndalen
Creators: name: (:Unas)
Publisher: name: G.B. Strøm
Year: 0
Subjects: Humor
Nyheter
Transport

description: Førstelinje: En frygtelig Historie.
description: Innhold: 8 vers, på 2 blad.
description: Melodi: "Maren Kokkepige" eller "Nu tænker jag"
description: Innhold: [1] Ny Vise om Jernbanemoroen ved Mjøndalen. [2] At Slyngler hæves til Ærens Top.
PT-symmetry breaking and maximal chirality in a nonuniform PT-symmetric ring
Creators: name: Scott, Derek D.
name: Joglekar, Yogesh N.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Physics (quant-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We study the properties of an N-site tight-binding ring with parity and time-reversal (PT) symmetric, Hermitian, site-dependent tunneling and a pair of non-Hermitian, PT-symmetric, loss and gain impurities $\pm iγ$. The properties of such lattices with open boundary conditions have been intensely explored over the past two years. We numerically investigate the PT-symmetric phase in a ring with a position-dependent tunneling function $t_α(k)=[k(N-k)]^{α/2}$ that, in an open lattice, leads to a strengthened PT-symmetric phase, and study the evolution of the PT-symmetric phase from the open chain to a ring. We show that, generally, periodic boundary conditions weaken the PT-symmetric phase, although for experimentally relevant lattice sizes $N \sim 50$, it remains easily accessible. We show that the chirality, quantified by the (magnitude of the) average transverse momentum of a wave packet, shows a maximum at the PT-symmetric threshold. Our results show that although the wavepacket intensity increases monotonically across the PT-breaking threshold, the average momentum decays monotonically on both sides of the threshold.
description: 11 pages, 5 figures, preprint
Dirac theory on a space with linear Lie type fuzziness
Creators: name: Shariati, A.
name: Khorrami, M.
name: Fatollahi, A. H.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: A spinor theory on a space with linear Lie type noncommutativity among spatial coordinates is presented. The model is based on the Fourier space corresponding to spatial coordinates, as this Fourier space is commutative. When the group is compact, the real space exhibits lattice characteristics (as the eigenvalues of space operators are discrete), and the similarity of such a \emph{lattice} with ordinary lattices is manifested, among other things, in a phenomenon resembling the famous \emph{fermion doubling} problem. A projection is introduced to make the dynamical number of spinors equal to that corresponding to the ordinary space. The actions for free and interacting spinors (with Fermi-like interactions) are presented. The Feynman rules are extracted and 1-loop corrections are investigated.
description: 1+14 pages, no figures
Ny Vise om Bonden som solgte Smør og ingen Penge fik
Creators: name: (:Unas)
Publisher: name: G.B. Strøm
Year: 0
Subjects: Humor
Bønder
Økonomi

description: Førstelinje: En Lørdags Morra til Byen jeg droe.
description: Innhold: 21 vers, på 2 blad.
description: Melodi: Tai aa dra
One-loop photon-photon scattering in a thermal, deconfining SU(2) Yang-Mills plasma
Creators: name: Krasowski, Niko
name: Hofmann, Ralf
Publisher: name: arXiv
Year: 2013
Subjects: subject: General Physics (physics.gen-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: For a deconfining thermal SU(2) Yang-Mills plasma we discuss the role of (anti)calorons in introducing non-thermal behavior effectively described in terms of Planck's quantum of action $\hbar$. This non-thermality cancels exactly between the ground-state estimate and its free quasiparticle excitations. Kinematic constraints in 4-vertex scattering and the counting of radial loop variables versus the number of independent constraints on them are re-visited. Next, we consider thermal 2$\rightarrow$ 2 one-loop scattering of the modes remaining massless upon the (anti)caloron induced adjoint Higgs mechanism (thermal ground state after spatial coarse graining). Starting with stringent analytical arguments, we are able to exclude the contribution to photon-photon scattering from diagrams containing at least one three-vertex and, in a next step, a vast majority of all possible configurations involving two four-vertices. By numerical analysis we show that the remaining contribution of the overall S channel is severely suppressed compared to that of the T and U channels, meaning that the creation of a pair of massive vector modes by a pair of photons and vice versa practically does not occur in the Yang-Mills plasma. For the T and U channels the domain of loop integration represents less than $10^{-7}$ times the volume of the unconstrained integration region. The thus introduced photon-photon correlation should affect the Cosmic Microwave Background's polarisation at low redshift. An adaption of the here-developed methods to the analysis of irreducible bubble diagrams could prove the conjecture of hep-th/0609033 on the termination of the loop expansion of thermodynamical quantities at a finite irreducible order.
description: 31 pp, 13 figures, 3 tables, v3: expanded abstract and introduction, errors in Tab. 1,2 corrected, Sec. 3.5 deleted, new Sec. added, slight change of title