cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Hard Problem of Consciousness and Neurobiological Naturalism
Creators: name: , Bailey Villarreal
Publisher: name: Georgia State University
Year: 2024

description:
In this thesis, I present Feinberg and Mallatt's (2020) theory of neurobiological naturalism and attempt to situate it within the broader philosophical discussion of consciousness. They propose what they consider to be the neurobiological components sufficient for phenomenal consciousness to have evolved and claim to have filled the explanatory gap in our understanding of how the brain gives rise to experience. I will argue that their claim for doing so is premature and rests on a fundamental misunderstanding of what distinguishes the hard and easy problems of consciousness, which results in a vicious circularity. I explore how Feinberg and Mallatt could respond and remain internally consistent with their theory. One way is an appeal to what I have called virtual irreducibility, which is an epistemic claim regarding the limitations of our knowledge of weakly emergent system properties. I consider this response, among others, and demonstrate why they are problematic.
Evidence as Dictator: When Arrows Impossibility Theorem Meets the Ethics of Belief
Creators: name: Wu, Chen-Wei
Publisher: name: Georgia State University
Year: 2024

description:
Could it be rational to believe contrary to the evidence if the belief brings a substantial amount of practical benefits? In my thesis, I investigate this question through the lens of social choice theory. Specifically, I argue that it is never rational to believe contrary to the evidence by utilizing Arrows impossibility theorem. To this end, I introduce an analogy between a belief system and a social group, discuss certain conditions that hold in a rational agents belief system, and compare and analyze the performances of different belief systems. The goal is to shed light on the role of evidence in a rational agents belief system while exploring the application of theoretical results in social choice theory to the ethics of belief.
Review of Mobile Learning Trends 2010-2015- A Meta-Analysis.pdf
Creators: name: KEN NEE CHEE
name: Noraffandy Yahaya
name: Nor Hasniza Ibrahim
name: Hasan, Mohamed Noor
Publisher: name: figshare
Year: 2017
Subjects: Education

description: This study examined the longitudinal trends of mobile learning (M-Learning) research using text mining techniques in a more comprehensive manner. One hundred and forty four (144) refereed journal articles were retrieved and analyzed from the Social Science Citation Index database selected from top six major educational technology-based learning journals based on Google Scholar metrics in the period from January, 2010 to December, 2015. Content analysis was implemented for further analysis based on (a) category of research purpose, (b) learning domain, (c) sample group, (d) device used, (e) research design, (f) educational contexts (i.e., formal learning and informal learning), (g) learning outcome (i.e., positive, negative and neutral), (h) periodic journal, (i) country, and (j) publisher. This review study of M-Learning presents findings, which can become a layover platform and guidance for researcher, educators, policy maker or even journal publisher for future research or reference in the realm of M-Learning regarding the latest trends.
Luminosity and the Phenomenal
Creators: name: Phillips, Henry
Publisher: name: Georgia State University
Year: 2024

description:
Though Timothy Williamson (2000) argues that we are not always in a position to know the phenomenal character of our experiences, critics retort that his argument overlooks views according to which the phenomenal properties involved in our experiences can serve to constitute our knowledge of their phenomenal character. I develop an argument against this view, contending that the phenomenal knowledge these critics envision would lack an adequate conceptual role: one who possessed such knowledge would nevertheless have no grasp of what it entailed or ruled out. At best, therefore, this knowledge cannot serve the foundational role its proponents imagine for it; and at worst, it will not count as knowledge at all. The upshot is that the best defense against Williamson turns out not to secure our epistemic foothold in the phenomenal realm.
Inference and Interpretation: Problems for Narrative as Testimony
Creators: name: Isett, Victoria
Publisher: name: Georgia State University
Year: 2024

description:
In this thesis, I argue that when an agent uses a narrative (i.e., a story) to communicate something to her hearer, she cannot be said to be giving testimony as it is traditionally understood in the literature in epistemology. Instead, many of the beliefs the hearer takes up on the basis of the speakers story will be derived by inferences and interpretations she must make on her own. If the authorship of the relevant beliefs does not belong to the speaker, then those beliefs are not ones transmitted via testimony. Thus, narratives are not forms of genuine testimony. However, I argue that this is not a reason to ignore the possible epistemic richness of storytelling. I conclude by encouraging my audience to take seriously the need for narrative to be granted an epistemology of its own, outside the constraints of testimony, lest we risk undermining the epistemic value of stories.
Carnet nº 28, commencé à Bugel (p. 9)
Creators: name: Péraire, Lucien
name: CNRS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023

description: created: 21-3-1932
Practical Contemplation and Happiness in Aristotle's Nicomachean Ethics
Creators: name: Romp, Jack
Publisher: name: Georgia State University
Year: 2024

description:
In Nicomachean Ethics X.7-8, Aristotle surprisingly claims that happiness is a contemplative activity. Commentators generally assume that he means happiness consists exclusively in theoretical contemplation. In this paper, I challenge that assumption by examining how Aristotle uses the term the?rein (to contemplate) to describe a practical kind of contemplation that is integral to virtuous action. Then, I argue that the contemplative activity Aristotle identifies with happiness in NE X.7-8 includes both practical and theoretical contemplation. This interpretation improves on existing explanations for why Aristotle thinks a life without theoretical contemplation can still be happy and why happiness requires moral virtue. Finally, I explain why Aristotles account of happiness is philosophically appealing by arguing that happiness can be understood as the contemplative recognition of the value of fine (kalon) objects in the universe and in practical affairs.
From Identity To Rights: Grounding Trans Right Through Sincere Self-Identity
Creators: name: Alder, Payden
Publisher: name: Georgia State University
Year: 2024

description:
Katharine Jenkins argues that Talia Bettchers Sincere Self-Identity or Existential account of gender identity cannot ground trans rights. Jenkins argues that Bettchers account reduces to the mere act of claiming a gender identity. Thus, Bettchers account fails to ground trans rights for two reasons: (1) it cannot show why gender identity ought to be respected, and (2) it cannot explain why a trans person would have a need for access to transition-related healthcare. I argue that Bettchers account is not reducible to the mere act of claiming a gender identity. Bettcher develops an account of gender identity that captures a persons identity broadly. She argues that existential accounts of gender identity include all of a persons beliefs (true or false), commitments, attitudes, and values. Thus, Jenkins misunderstanding of Bettchers account of gender identity. I then argue that Bettchers account when correctly understood does have the resources to ground trans rights.
Social Domination and the Class Structure: Extending Left-Republicanism
Creators: name: Hettinger, Alan
Publisher: name: Georgia State University
Year: 2024

description:
There is a debate in republican political philosophy concerning whether, and under what circumstances, workers are dominated. Philosophers such as Pettit, Anderson, Gourevitch, and Vrousalis argue that employers dominate workers, either in extreme circumstances or as a necessity under capitalism. Some, such as Vrousalis, argue the domination of workers is a structural feature of capitalism. Others, such as Pettit, argue workplace domination is an extreme to protect against. I argue that capitalism requires the vulnerability of workers as a class to domination. Republicans who view workplace domination as an extreme fail to account for the structural cause of that domination. Capitalism requires profit-maximization, which requires the vulnerability of the working class so that workers will accept working in ways that are contrary to their interests, and over which they lack control. My argument parallels, but is distinct from, accounts of structural domination given by Gourevitch and Vrousalis, among others.
title: KLIMONAS-Ch29-A06 - Sus scrofa ssp., Klimonas, Secteur Central. Données brutes des âges dentaires d’abattage. Maxillaire (1/2)
title: KLIMONAS-Ch29-A06 - Sus scrofa ssp., Klimonas, Central Sector. Raw data of the dental age-at-death. Maxillar (1/2)
Creators: name: CUCCHI, Thomas
name: VIGNE, Jean-Denis
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023

description: Appendix of: Vigne J.-D., Briois F., Guilaine J. (eds.), « Klimonas, an Early Pre-Pottery Neolithic village in Cyprus », Gallia Préhistoire & Paléorient, International Supplement 1, CNRS Éditions, Paris, 2023.
description: Annexe de : Vigne J.-D., Briois F., Guilaine J. (dir.), « Klimonas, un village néolithique pré-céramique ancien à Chypre », Gallia Préhistoire & Paléorient, Supplément international 1, CNRS Éditions, Paris, 2023.
A bipolar electrospray source of singly charged salt clusters of precisely controlled composition
Creators: name: Mora, Juan Fernandez De La
name: Barrios-Collado, César
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: The few clusters [B−nA+n+1]+ (n = 0,1) with resolvable mobilities formed in electrosprays of large salts have been used for nanoparticle instrument testing and calibration at sizes smaller than 2 nm. Extensions of this modest size range by charge reduction with uncontrolled gas phase ions has resulted in impure singly charged clusters. Here, we combine two oppositely charged electrosprays of solutions of the same salt B−A+, including: (CnH2n+1)4N+Br− (n = 4,7,12,16), the large phosphonium cation (C6H13)3(C16H33)P+ paired with the anions Im− [(CF3SO2)2N−] or FAP− [(C2F5)3PF3−], and the asymmetric pair [1-methyl-3-pentylimidazolium+FAP−]. Both polarities are simultaneously produced by this source in comparable abundances, primarily as singly charged A+nB−n±1, with tiny contributions from higher charge states. Some but not all of these clusters produce narrow mobility peaks typical of pure ions, even beyond n = 43. Excellent independent stable control of the positive and the negative sprays brought very close to each other is achieved by isolating them electrostatically with a symmetrically interposed metallic screen. Two nanoDMAs covering the size range up to 30 nm (Halfmini and Herrmann DMAs, with classification lengths of 2 and 10 cm) are characterized with these standards, revealing resolving powers considerably higher than previously seen with unipolar electrospray sources. The bipolar source of pure and chemically homogeneous clusters described permits studying size and charge effects in a variety of aerosol instruments in the 1–4 nm size range. Copyright © 2017 American Association for Aerosol Research
"Bibliotheques françoises" (BibFr) : avancées de l'indexation & évolutions de la base de données 2023.
Creators: name: Uetani, Toshinori
name: Porte, Guillaume
Publisher: name: Bibliothèques Virtuelles Humanistes. Zenodo
Year: 2024
Subjects: heurist
XML-TEI
BibFr
La Crois du Maine
Renaissance
Catalogue
Bibliothèques anciennes
édition numérique
Données bibliographiques
Données prosopographiques
réseaux culturels
XVIe
Referentiels

description: Avancées de l’indexation & évolutions de la base de données "Bibliotheques françoises" (BibFr), par Toshinori Uetani (CESR, Tours) et Guillaume Porte (ARCHE, Strasbourg), à l'occasion de l’assemblée générale 2023 du programme de recherche « Bibliothèques Virtuelles Humanistes » (CESR, Tours) et de l'anniversaire des 20 ans du programme BVH. Vendredi 24 novembre 2023, au Centre d’Études Supérieures de la Renaissance de Tours.
Supplementary material from: Quantifying social media predictors of violence during the 6 January US Capitol insurrection using Granger causality
Creators: name: Lee, Qinghua
name: King, Brayden
name: Uzzi, Brian
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 310499
subject: Evolutionary biology not elsewhere classified
classificationCode: 440899
subject: Political science not elsewhere classified

description: Protests involving brute force are growing in number and are viewed as a likely source of increased collective violence in industrialized nations. Yet, our scientific understanding of how violent protests are related to a leader’s social media communications during protests remains nascent. Here we analyze new data from the January 6th march on the U.S. Capitol to quantify the links between leadership, social media, and levels of violence. Using data on thousands of live footage videos, Trump’s tweets and rally speech, other rally speeches, and #StopTheSteal tweets, we apply Granger regression methods to analyze the links between former President Trump’s tweets, #StopTheSteal tweets, rally speeches, and the severity and duration of outbreaks of violence and weapons use during the riot. We find that Trump’s tweets predict bursts in rioters’ levels and duration of violence and weapons use. Trump’s tweets also predict changes in the volume and sentiments of #StopTheSteal tweets, which in turn explain additional variance in levels of violence and weapons use over the course of the riot. Our findings reveal new patterns of behavior that link an authority figure’s online behavior during a protest and the shift from peaceful protesting to violence.
ABC News/Washington Post Poll: Trump/Congressional Election
Creators: name: ABC News
name: Washington Post
Publisher: name: Roper Center for Public Opinion Research
Year: 2020

description: President Donald Trump job performance (1); registered to vote (1); following election closely (1); voter likelihood (1); vote for Democratic/Republican candidate in congressional district (3); importance of opinions shared by candidate (1); trust Republicans or Democrats (8); importance of issues in your vote for Congress (7); state of nation's economy (1); better or worse off financially since Trump became President (1); Trump encouraging political violence (1); news media encouraging political violence (1); how much it matters that you personally vote (1); political information on social media (1); voted in 2016 presidential election (1); voted in 2014 congressional election (1).
Trade and Poverty Issues: A Country Case Study of the Philippines
Creators: name: Sta. Romana, Leonardo L.
Publisher: name: Zenodo
Year: 2017
Subjects: Trade, Poverty, Rural, Informal Sector, Asia, South East Asia, Philippines, Development Economics, Structural Transformation, Inclusive Growth, Unemployment, Underemployment

description: ABSTRACT This study begins with an overview of the poverty situation in the Philippines. It then takes a brief look at the poor in the rural areas, followed with a discussion of the poor in the informal sector. Then, it brings these two sectors together, with an examination of the poor and the urban/rural and formal/informal divides. It concludes with a discussion of the relationship among trade, poverty and the structural transformation of the Philippine economy.
description: This paper was written in response to a joint call for papers by the World Trade Organization and the World Bank. A detailed and comprehensive abstract, on which this paper is based, went through the screening process of a WTO/World Bank selection committee.
Some Lessons from South Korea's Industrialization Strategy and Experience
Creators: name: Sta. Romana, Leonardo L.
Publisher: name: Zenodo
Year: 2014
Subjects: South Korea, Industrialization, Industrial Strategy, Economic Development, Exports, Trade, Economic Planning, Economic Growth, East Asia, Newly Industrialized Countries, Japanese Economic Model

description: ABSTRACT We look at Korea's industrialization strategy and experience from the 1960s to the mid-1990s. Three elements of the Korean industrial development and structural
 change are discussed: 1) its outward orientation and export push, 2) its climb up the ladder of comparative advantage, and 3) its economic management of the industrialization effort. Finally, we reflect on the lessons from the Korean experience.
description: This paper was written in response to a call for papers by the Global Development Network, a public international organization headquartered in New Delhi, with an office in Washington, DC.
title: Fiche Module CESU "Traitement de l’image photographique"
Creators: name: LabexMed
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Formation sur le Traitement de l’image photographique, réalisée par Loic Damelet (CCJ).
Four new anthraquinones from a soil actinomycete Streptomyces sp. WS-13394 and their bioactivities
Creators: name: Wu, Zhaoyuan
name: Zhang, Yani
name: Fang, Wei
name: Shi, Liqiao
name: Wan, Zhongyi
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: Further chemical study of secondary metabolites from the soil actinomycete Streptomyces sp. WS-13394 resulted in the isolation of four new alkylated anthraquinone analogues (5–8). Their structures were elucidated on the basis of extensive spectroscopic analysis, including HR-ESI-MS, 1D and 2D NMR. The new compounds, together with analogues obtained before (1–4), were tested for their in vitro cytotoxicity against Huh-7 and SGC-7901.
THE ROLE OF INNOVATIVE TECHNOLOGIES IN EDUCATION
Creators: name: Norqulov, Bekzod
Publisher: name: Zenodo
Year: 2024

description: The article explores the transformative impact of innovative technologies on education in the 21st century, highlighting both their benefits and challenges. It underscores how technologies such as multimedia tools, AI, and VR have enhanced student engagement, personalized learning experiences, and improved accessibility, especially for remote and disabled learners. Additionally, it emphasizes the role of these technologies in fostering collaboration, real-world applications, and critical thinking skills. It concludes by asserting the pivotal role of innovative technologies in modernizing education, making it more inclusive and effective, while stressing the need to overcome existing challenges to fully harness their potential.
Techtile -- Open 6G R&D Testbed for Communication, Positioning, Sensing, WPT and Federated Learning
Creators: name: Callebaut, Gilles
name: Van Mulders, Jarne
name: Ottoy, Geoffrey
name: Delabie, Daan
name: Cox, Bert
name: Stevens, Nobby
name: Van der Perre, Liesbet
Publisher: name: arXiv
Year: 2022
Subjects: subject: Signal Processing (eess.SP)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: New concepts for next-generation wireless systems are being developed. It is expected that these 6G and beyond systems will incorporate more than only communication, but also sensing, positioning, (deep) edge computing, and other services. The discussed measurement facility and approach, named Techtile, is an open, both in design and operation, and unique testbed to evaluate these newly envisioned systems. Techtile is a multi-functional and versatile testbed, providing fine-grained distributed resources for new communication, positioning and sensing technologies. The facility enables experimental research on hyper-connected interactive environments and validation of new algorithms and topologies. The backbone connects 140~resource units equipped with edge computing devices, software-defined radios, sensors, and LED sources. By doing so, different network topologies and local-versus-central computing can be assessed. The introduced diversity of i) the technologies (e.g., RF, acoustics and light), ii) the distributed resources and iii) the interconnectivity allows exploring more degrees and new types of diversity, which can be investigated in this testbed.
description: arXiv admin note: substantial text overlap with arXiv:2105.06740
Using prior knowledge in frequentist tests
Creators: name: Bartels, Christian
Publisher: name: figshare
Year: 2019
Subjects: subject: 10405 Statistical Theory
subject: FOS: Mathematics
subject: Statistics
subject: Probability

description: This manuscript aims at expanding the armory for decision making under uncertainty with complex models, focusing on trying to expand the reach of decision theoretic, frequentist methods. In prior work an efficient integration method was re-evaluated for repeated calculation of statistical integrals for a set of of hypotheses (e.g., p-values, confidence intervals). Key to the method was the use of importance sampling. Subsequently, pointwise mutual information was proposed as an efficient test statistics and shown to be optimal under certain conditions. Here, proposals are made for optimal frequentist test statistics that can take into account prior knowledge and avoid Minimax optimisations.
Three multinuclear Co(II), Zn(II) and Cd(II) complexes based on a single-armed salamo-type bisoxime: syntheses, structural characterizations and fluorescent properties
Creators: name: Hao, Jing
name: Liu, Ling-Zhi
name: Dong, Wen-Kui
name: Zhang, Jing
name: Zhang, Yang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: Biophysics
Biochemistry
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Marine Biology

description: Three multinuclear complexes, [Co(L)(OAc)Co(CH3CH2OH)2]·H2O, [Zn(L)(OAc)Zn(CH3OH)], and [{Cd(L)(OAc)Cd(CH3OH)}2], containing a single-armed salamo-type bisoxime H3L have been synthesized and characterized structurally. The Co(II) complex forms a dimeric unit by intermolecular hydrogen bond interactions of neighboring dimeric molecules. The Zn(II) complex also forms a dimeric unit by intermolecular hydrogen bond interactions. Interesting features of the crystal structure include O⋯O short contacts. Meanwhile, self-assembling infinite 1-D, 2-D, and 3-D supramolecular structures are formed by intermolecular hydrogen bond and C–H⋯π interactions. The Cd(II) complex forms an infinite 2-D supramolecular structure by intermolecular hydrogen bond interactions. The photophysical properties of the Co(II), Zn(II), and Cd(II) complexes have also been discussed.
Three multinuclear Co(II), Zn(II) and Cd(II) complexes based on a single-armed salamo-type bisoxime: Syntheses, structural characterizations and fluorescent properties
Creators: name: Hao, Jing
name: Liu, Ling-Zhi
name: Dong, Wen-Kui
name: Zhang, Jing
name: Zhang, Yang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: Biophysics
Biochemistry
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Marine Biology

description: Three multinuclear complexes, [Co(L)(OAc)Co(CH3CH2OH)2]·H2O, [Zn(L)(OAc)Zn(CH3OH)] and [{Cd(L)(OAc)Cd(CH3OH)}2], containing a single-armed salamo-type bisoxime H3L have been synthesized and characterized structurally. The Co(II) complex forms a dimeric unit by intermolecular hydrogen bond interactions of neighboring dimeric molecules. The Zn(II) complex also forms a dimeric unit by intermolecular hydrogen bond interactions. Interesting features of the crystal structure include O···O short contacts. Meanwhile, self-assembling infinite 1D, 2D and 3D supramolecular structures are formed by intermolecular hydrogen bond and C–H···π interactions. The Cd(II) complex forms an infinite 2D supramolecular structure by intermolecular hydrogen bond interactions. The photophysical properties of the Co(II), Zn(II) and Cd(II) complexes have also been discussed.
Source Code Archiving to the Rescue of Reproducible Deployment
Creators: name: Courtès, Ludovic
name: Sample, Timothy
name: Tournier, Simon
name: Zacchiroli, Stefano
Publisher: name: arXiv
Year: 2024
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: The ability to verify research results and to experiment with methodologies are core tenets of science. As research results are increasingly the outcome of computational processes, software plays a central role. GNU Guix is a software deployment tool that supports reproducible software deployment, making it a foundation for computational research workflows. To achieve reproducibility, we must first ensure the source code of software packages Guix deploys remains available.We describe our work connecting Guix with Software Heritage, the universal source code archive, making Guix the first free software distribution and tool backed by a stable archive. Our contribution is twofold: we explain the rationale and present the design and implementation we came up with; second, we report on the archival coverage for package source code with data collected over five years and discuss remaining challenges.
description: 2024 ACM Conference on Reproducibility and Replicability, Jun 2024, Rennes, France
Two pairs of rare naturally occurring 4-hydroxy-4-methyl-2,5-heptanedione derivatives from the red alga Chondria crassicaulis
Creators: name: Tong, Lin
name: Zhang, Yi
name: Liu, Ai-Hong
name: Yao, Li-Gong
name: Guo, Yue-Wei
name: Mao, Shui-Chun
name: Wang, Bin
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Two pairs of rare naturally occurring racemic lipids, (±)-4,7-dihydroxy-4-methyl-2,5-heptanedione (1), and (±)-7-butoxy-4-hydroxy-4-methyl-2,5-heptanedione (2) were isolated from the red alga Chondria crassicaulis Harv. The structures of the racemic mixtures of 1 and 2 were elucidated by detailed spectroscopic techniques, including 1D and 2D NMR (1H and 13C NMR, 1H–1H COSY, HSQC, and HMBC) as well as mass spectrometry and optical rotation experiments, and by comparison with data for related known analogs. This is the first report of naturally occurring 4-hydroxy-4-methyl-2,5-heptanedione derivatives. Antifungal, PTP1B inhibitory, and receptor tyrosine kinase inhibitory activities of these two compounds were investigated. The results showed that compounds 1 and 2 exhibited good selective inhibition against RET tyrosine kinase activity with IC50 values of 9.56 and 8.93 μM, respectively. Compound 1 also displayed moderate antifungal activity against Cryptococcus neoformans (32609), showing a MIC80 value of 32 μg/ml.
Cannabis use by women during pregnancy does not influence infant DNA methylation of the dopamine receptor DRD4
Creators: name: Fransquet, Peter D.
name: Hutchinson, Delyse
name: Olsson, Craig A.
name: Allsop, Steve
name: Elliott, Elizabeth J.
name: Burns, Lucinda
name: Mattick, Richard
name: Saffery, Richard
name: Ryan, Joanne
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Background: Maternal cannabis use in pregnancy is linked with long-term adverse behavioral outcomes in offspring. Epigenetic processes established in utero that affect dopaminergic (reward) signaling may mediate risks. Associations between cannabis use and offspring DNA methylation have not been investigated; however, maternal tobacco smoking in pregnancy is associated with distinct patterns of DNA methylation at birth and beyond. Objectives: To determine whether maternal cannabis use is associated with methylation of the dopamine receptor gene DRD4 promoter in infants. Methods: Mothers in the Triple B study provided detailed information on drug use in each trimester of pregnancy. Buccal swabs were collected from neonates at 8 weeks (n = 804, 51.7% male, and 48.3% female). DRD4 promoter DNA methylation was measured using SEQUENOM MassARRAY. Results: Fifty-seven of the women in the study reported drug use during pregnancy, of whom 44 used cannabis. Of 19 cytosine-phosphate-guanine dinucleotides (CpG) units tested in DRD4, gestational cannabis use was associated with offspring methylation at 1 CpG unit in multivariate models (β + 1.48, CI: 0.02 to 2.93, and p = 0.047). At another site there was weak evidence that both cannabis and other drug use were independently associated with increased methylation, while the association with tobacco was in the reverse direction (cannabis use β + 0.67, CI: −0.12 to 1.46, and p = 0.09; other drug use β + 1.11, CI: 0.17 to 2.05, and p = 0.02; tobacco use β −0.41, CI: −0.85 to 0.03, and p = 0.07). None of the associations would remain significant after correction for multiple testing. Conclusion: There is no strong evidence that maternal cannabis use in pregnancy is associated with offspring DRD4 methylation.
Realist evaluation of faculty development for medical educators: What works for whom and why in the long-term
Creators: name: Olanrewaju O. Sorinola
name: Thistlethwaite, Jill
name: Davies, David
name: Peile, Ed
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Science Policy

description: Purpose: Realism is a perspective in which entities exist independently of being perceived or independently of our theories about them. The realist framework with its principle of explanatory causation was used for an in-depth exploration of faculty development (FD) since, despite the widespread investment in FD, the evidence that it enhances the effectiveness of teaching in the long-term is still limited. The study aimed to develop realist theories that explain the connections between contexts (C), mechanisms (M) and outcomes (O) to find out what works for whom and why in FD. Methods: Purposive sampling was used to select two medical schools from each of the four UK regions (total 8 of the 33 UK medical schools) for interview of a faculty development coordinator and a medical educator at each school. Sixteen interviews were carried out. Data were coded and summarized under contexts, mechanisms, and outcomes (CMO) to derive realist theories. Results: We identified contexts that facilitated FD mechanisms of engagement, motivation, positive perception and professionalization, which led to educators’ outcomes of improved confidence, competence, credibility and career progression. Conclusion: Four realist theories, which support the effectiveness of FD in the long-term, were derived, enabling recommendations for FD stakeholders.
title: 02_0990
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Geopolitics of Energy.
Creators: name: Victoria, Artur
Publisher: name: Zenodo
Year: 2020

description: The twentieth century witnessed the biggest shift in energy sources the world has perhaps experienced since the use of fire was widespread. In the first twenty-five years of the century, coal was arguably the main source of energy for the industrialized world. The energy needs of large countries could be met entirely by domestic resources or supplemented by sources close by (in the case of Japan). Coal would have continued to be the main source of energy if the discovery of large quantities of oil in southern Russia, the Middle East and, later, in the United States, had not quickly aroused interest in the comparative ease of its extraction and transportation , and its conversion to meet a wide range of needs. What circumstances caused the oil revolution in the mid-fifties? What circumstances led to your availability being placed at the top of national priorities? These questions can be illustrated by statistical references to the increase in energy consumption, starting in 1960 (the year in which the Organization of the Petroleum Exporting Countries [OPEC) was founded); that year, world energy consumption was of the order of 132 quintillion British Thermal Units (QBTU); ten years later, it was 217 QBTU; five years later, in 1975, it reached about 225 QBTU. In 1990, the 415 QBTU - a three-fold increase in world energy consumption in just thirty years. What was the share of oil (and natural gas) in these increases? In 1960, they accounted for 48 percent of the world's energy consumption. Ten years later, participation had increased to 63 percent; in 1975, it was already 67 percent; and in 1990, even if we assume a large contribution from nuclear energy, the share of oil and natural gas reaches 85 percent. The implications in terms of quantity are impressive. Eight billion barrels of oil consumed worldwide in 1960, 17 billion barrels in 1975, and 30 billion barrels in 1980: an almost four-fold increase in oil and gas consumption. Ten years later, participation had increased to 63 percent; in 1975, it was already 67 percent; and in 1990, even if we assume a large contribution from nuclear energy, the share of oil and natural gas reaches 85 percent. The implications in terms of quantity are impressive. Eight billion barrels of oil consumed worldwide in 1960, 17 billion barrels in 1975, and 30 billion barrels in 1980: an almost four-fold increase in oil and gas consumption in thirty years. Coal, on the other hand, which had been the main source of energy, was still responsible for 47 percent of the world's energy consumption in 1960, but fell to 30 percent in 1976.
Multi-wavelength spectrophotometric determination of pH using phenol red–doped sol–gel film sensors
Creators: name: Wang, Hongliang
name: Liu, Baohua
name: Li, Zhengguang
name: Yang, Lei
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Statistics
subject: FOS: Mathematics
subject: Infectious Diseases
subject: FOS: Health sciences

description: Dye leakage and the nonlinear relationship between absorbance and pH affect the pH measurement precision of absorption-based optic sensors and limit their application. Based on the preparation of a transparent sol–gel thin film with a phenol red indicator, this work assumed that the absorbancies had an exponential relationship to the concentrations of the indicator, and the multi-wavelength equation for the pH was derived as follows:

where n is the exponential coefficient, e1, e2, and e3 are the extinction coefficient ratios, and R is the ratio of the absorbancies. The calculation parameters for an immobilized phenol red film were pKa = 8.577, e1 = 0.0191, e2 = 1.530, e3 = 0.2992, and n = 0.6322, while those for an immobilized phenol red/Triton X-100 film were pKa = 8.612, e1 = 0.0507, e2 = 1.501, e3 = 0.3687, and n = 0.3931. The correspondence between the calculated pKa and the pKa from the calibration curve verifies the equation. The calculation parameters remain stable as the indicator content is increased, but change with an increase in the Triton X-100 content. Using the equation, the calculated pH shows stable behavior over a long duration regardless of dye leakage, and the calculated precision is 0.0053. The method provides drift-free and precise water pH measurements for R that is not dependent on the total concentration of the indicator, and can be applied to online monitoring.
Multi-Wavelength Spectrophotometric Determination of pH using Phenol Red-Doped Sol–Gel Film Sensors
Creators: name: Wang, Hongliang
name: Liu, Baohua
name: Li, Zhengguang
name: Yang, Lei
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Statistics
subject: FOS: Mathematics
subject: Infectious Diseases
subject: FOS: Health sciences

description: Dye leakage and the non-linear relationship between absorbance and pH affect the pH measurement precision of absorption-based optic sensors and limit their application. Based on the preparation of a transparent sol–gel thin film with a phenol red indicator, this work assumed that the absorbancies had an exponential relationship to the concentrations of the indicator, and the multi-wavelength equation for the pH was derived as follows:

Where n is the exponential coefficient, e1, e2, and e3 are the extinction coefficient ratios, and R is the ratio of the absorbancies. The calculation parameters for an immobilized phenol red film were pKa = 8.577, e1 = 0.0191, e2 = 1.530, e3 = 0.2992, and n = 0.6322, while those for an immobilized phenol red/ Triton X-100 film were pKa = 8.612, e1 = 0.0507, e2 = 1.501, e3 = 0.3687, and n = 0.3931. The correspondence between the calculated pKa and the pKa from the calibration curve verifies the equation. The calculation parameters remain stable as the indicator content is increased, but change with an increase in the Triton X-100 content. Using the equation, the calculated pH shows stable behavior over a long duration regardless of dye leakage, and the calculated precision is 0.0053. The method provides drift-free and precise water pH measurements for R that is not dependent on the total concentration of the indicator, and can be applied to online monitoring.
Liriopesides B inhibited cell growth and decreased CA125 level in human ovarian cancer A2780 cells
Creators: name: Wang, Haiyan
name: Yu, Haizhong
name: Sun, Yonglin
name: Zhao, Huijun
name: Guo, Zhuang
name: Yu, Bo
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: To study the effect of liriopesides B on cell growth curve, cell doubling time, the activity of tumour marker CA125 and alkaline phosphatase (AKP) in human ovarian cancer A2780 cells. Both cell growth curve and doubling time were studied by MTT assay, CA125 level and AKP activity were determined by respective kits. Results showed that liriopesides B could shift down the A2780 cells growth curve in a dose-time-dependent manner and inhibit the proliferation in A2780 cells with the maximum inhibitory rate 94.462% at 120 h, the doubling time was prolonged too. CA125 level was decreased in a dose-dependent way as well as AKP activity. Liriopesides B exhibited potential anticancer activity against human ovarian cancer A2780 cells.
Uncover it, students would learn leadership from Team-Based Learning (TBL): The effect of guided reflection and feedback
Creators: name: Alizadeh, Maryam
name: Mirzazadeh, Azim
name: Parmelee, Dean X.
name: Peyton, Elizabeth
name: Janani, Leila
name: Gholamreza Hassanzadeh
name: Saharnaz Nedjat
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Cell Biology
subject: Neuroscience
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Context: Little is known about best practices for teaching and learning leadership through Team-Based learning™ (TBL™) with medical students. We hypothesized that guided reflection and feedback would improve shared leadership and shared leadership capacity, and enhance team decision quality in TBL teams. We used the Kolb experiential learning theory as the theoretical framework. Method: The study was conducted at Tehran University of Medical Sciences. Three TBL sessions with 206 students (39 teams) participated in the study. Using a quasi-experimental design, one batch received guided reflection and feedback on their team leadership processes (n = 20 teams) and the other received only TBL (n = 19 teams). Observers measured shared leadership using a checklist. Shared leadership capacity was measured using a questionnaire. Scores on a team application exercise were used to assess quality of team decisions. Results: Evidence did not support our first hypothesis that reflection and feedback enhance shared leadership in TBL teams. Percentages of teams displaying shared leadership did not differ between intervention and control groups in sessions 1 (p = 0.6), 2 (p = 1) or 3 (p = 1). The results did not support the second hypothesis. We found no difference in quality of decision making between the intervention and control groups for sessions 1 (p = 0.77), 2 (p = 0.23), or 3 (p = 0.07). The third hypothesis that the reflection and feedback would have an effect on shared leadership capacity was supported (T = −8.55, p > 0.001 adjusted on baseline; T = −8.55, p > 0.001 adjusted on gender). Discussion and conclusion: We found that reflection and feedback improved shared leadership capacity but not shared leadership behaviors or team decision quality. We propose medical educators who apply TBL, should provide guided exercise in reflection and feedback so that students may better understand the benefits of working in teams as preparation for their future roles as leaders and members of health care teams.
Yield and Gel Strength of Gelatin Extracted from Smoked Salmon (Salmo salar) Skins
Creators: name: Zhang, Yue
name: Regenstein, Joe M.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: The gelatin yield and gel strength of gelatin extracted from the skins of smoked salmon were determined. The skins had a crude protein content of 43.5 ± 1.2% and an estimated collagen content of 23.6 ± 1.0%. Following an alkali extraction process under varying extraction conditions, the protein content varied from 2.78% to 32.1%, and the gelatin yield ranged from 2.23% to 22.4% of the initial skin weight. The gelatin purity (gelatin/protein) ranged from 55.4% to 100%, with the highest Hyp/protein sample arbitrarily designated as being 100% pure, i.e., an assumption of pure gelatin. Statistical analysis showed that HCl concentration, pretreatment temperature, and extraction temperature significantly affected the protein yield and gelatin yield. The wide range of gel strengths indicates that the gelatin might have been hydrolyzed to different extents during the different extraction and cooling processes. Statistical analysis did not show that any of the factors studied affected the gel strength. However, the data indicated that low NaOH concentrations and HCl concentrations might not prevent hydrolysis during the extraction process. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS–PAGE) showed that the gelatins contained α- and β-chains and that the gelatins composed of higher concentrations of larger molecular weight polypeptide chains had higher gel strengths.
Using prior knowledge in frequentist tests
Creators: name: Bartels, Christian
Publisher: name: figshare
Year: 2017
Subjects: subject: 10405 Statistical Theory
subject: FOS: Mathematics
subject: Statistics
subject: Probability

description: This manuscript aims at expanding the armory for decision making under uncertainty with complex models, focusing on trying to expand the reach of decision theoretic, frequentist methods. In prior work an efficient integration method was re-evaluated for repeated calculation of statistical integrals for a set of of hypotheses (e.g., p-values, confidence intervals). Key to the method was the use of importance sampling. Subsequently, pointwise mutual information was proposed as an efficient test statistics and shown to be optimal under certain conditions. Here, proposals are made for optimal frequentist test statistics that can take into account prior knowledge and that could deal with nuisance parameters.