cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Yeast alpha mating factor structure-activity relationship derived from genetically selected peptide agonists and antagonists of Ste2p.
Creators: name: Klein, C
name: Broach, J R
name: Wiesler, W T
name: Byrd, D R
name: Trueheart, J
name: Fowlkes, D M
name: Manfredi, J P
name: Herrero, J J
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: alpha-Factor, a 13-amino-acid pheromone secreted by haploid alpha cells of Saccharomyces cerevisiae, binds to Ste2p, a seven-transmembrane, G-protein-coupled receptor present on haploid alpha cells, to activate a signal transduction pathway required for conjugation and mating. To determine the structural requirements for alpha-factor activity, we developed a genetic screen to identify from random and semirandom libraries novel peptides that function as agonists or antagonists of Ste2p. The selection scheme was based on autocrine strains constructed to secrete random peptides and respond by growth to those that were either agonists or antagonists of Ste2p. Analysis of a number of peptides obtained by this selection procedure indicates that Trp1, Trp3, Pro8, and Gly9 are important for agonist activity specifically. His2, Leu4, Leu6, Pro10, a hydrophobic residue 12, and an aromatic residue 13 are important for both agonist and antagonist activity. Our results also show that activation of Ste2p can be achieved with novel, unanticipated combinations of amino acids. Finally, the results suggest the utility of this selection scheme for identifying novel ligands for mammalian G-protein-coupled receptors heterologously expressed in S. cerevisiae.
Full Halo Coronal Mass Ejections: Arrival at the Earth
Creators: name: Shen, Chenglong
name: Wang, Yuming
name: Pan, Zonghao
name: Miao, Bin
name: Ye, Pinzhong
name: Wang, S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: A geomagnetic storm is mainly caused by a front-side coronal mass ejection (CME) hitting the Earth and then interacting with the magnetosphere. However, not all front-side CMEs can hit the Earth. Thus, which CMEs hit the Earth and when they do so are important issues in the study and forecasting of space weather. In our previous work (Shen et al., 2013), the de-projected parameters of the full-halo coronal mass ejections (FHCMEs) that occurred from 2007 March 1 to 2012 May 31 were estimated, and there are 39 front-side events could be fitted by the GCS model. In this work, we continue to study whether and when these front-side FHCMEs (FFHCMEs) hit the Earth. It is found that 59\% of these FFHCMEs hit the Earth, and for central events, whose deviation angles $ε$, which are the angles between the propagation direction and the Sun-Earth line, are smaller than 45 degrees, the fraction increases to 75\%. After checking the deprojected angular widths of the CMEs, we found that all of the Earth-encountered CMEs satisfy a simple criterion that the angular width ($ω$) is larger than twice the deviation angle ($ε$). This result suggests that some simple criteria can be used to forecast whether a CME could hit the Earth. Furthermore, for Earth-encountered CMEs, the transit time is found to be roughly anti-correlated with the de-projected velocity, but some events significantly deviate from the linearity. For CMEs with similar velocities, the differences of their transit times can be up to several days. Such deviation is further demonstrated to be mainly caused by the CME geometry and propagation direction, which are essential in the forecasting of CME arrival.
description: 9 Pages, 9 Figures,Accepted by JGR
title: Storie di persone di terre e lavoro [poster]
title: Storie di persone di terre e lavoro [poster]
title: Movimenti contadini e lotte degli assegnatari calabresi (1950-1958)
titleType: AlternativeTitle
Creators: name: Mazza, Prospero Francesco
name: Barbaro, Dario
name: Molè, Federica
name: Iorio, Mario
Publisher: name: P. F. Mazza et al., "Storie di persone di terre e lavoro", in Anvedi che storia! VI Conferenza Nazionale AIPH. Dipartimento di Studi Umanistici, Università degli Studi Roma Tre. Roma, 10-14 giugno 2024.
Year: 2024

description: Un progetto di Public & Digital History per la valorizzazione e il recupero delle memorie contadine degli assegnatari calabresi.
Exciton condensation in strongly correlated quantum spin Hall insulators
Creators: name: Amaricci, A.
name: Mazza, G.
name: Capone, M.
name: Fabrizio, M.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Time reversal symmetric topological insulators are generically robust with respect to weak local interaction, unless symmetry breaking transitions take place. Using dynamical mean-field theory we solve an interacting model of quantum spin Hall insulators and show the existence, at intermediate coupling, of a symmetry breaking transition to a non-topological insulator characterised by exciton condensation. This transition is of first order. For a larger interaction strength the insulator evolves into a Mott one. The transition is continuous if magnetic order is prevented, and notably, for any finite Hund's exchange it progresses through a Mott localization before the condensate coherence is lost. We show that the correlated excitonic state corresponds to a magneto-electric insulator which allows for direct experimental probing. Finally, we discuss the fate of the helical edge modes across the excitonic transition.
description: 8 pages, 5 figures
Thermodynamic Control of Activity Patterns in Cytoskeletal Networks
Creators: name: Lamtyugina, Alexandra
name: Qiu, Yuqing
name: Fodor, Étienne
name: Dinner, Aaron R.
name: Vaikuntanathan, Suriyanarayanan
Publisher: name: arXiv
Year: 2021
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Physical sciences

description: We aim to identify the control principles governing the adaptable formation of non-equilibrium structures in actomyosin networks. We build a phenomenological model and predict that biasing the energy dissipated by molecular motors should effectively renormalize the motor-mediated interactions between actin filaments. Indeed, using methods from large deviation theory, we demonstrate that biasing energy dissipation is equivalent to modulating the motor rigidity and results in an aster-to-bundle transition. From the simulation statistics, we extract a relation between the biasing parameter and the corresponding normalized motor rigidity. This work elucidates the relationship between energy dissipation, effective interactions, and pattern formation in active biopolymer networks, providing a control principle of cytoskeletal structure and dynamics.
description: 6 pages, 2 figures
Precise QCD predictions for the production of Higgs+jet final states
Creators: name: Chen, X.
name: Gehrmann, T.
name: Glover, E. W. N.
name: Jaquier, M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We compute the cross section and differential distributions for the production of a Standard Model Higgs boson in association with a hadronic jet to next-to-next-to-leading order in quantum chromodynamics (QCD). In Higgs boson studies at the LHC, final states containing one jet are a dominant contribution to the total event rate, and their understanding is crucial for improved determinations of the Higgs boson properties. We observe substantial higher order corrections to transverse momentum spectra and rapidity distributions in Higgs-plus-one-jet final states. Their inclusion stabilises the residual theoretical uncertainty of the predictions around 9\%, thereby providing important input to precision studies of the Higgs boson.
ZDS1 and ZDS2, genes whose products may regulate Cdc42p in Saccharomyces cerevisiae.
Creators: name: Pringle, J R
name: Bi, E
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: A genetic screen for GTPase-activating proteins (GAPs) or other negative regulators of the Rac/Rho family GTPase Cdc42p in Saccharomyces cerevisiae identified ZDS1, a gene encoding a protein of 915 amino acids. Sequence from the yeast genome project identified a homolog, ZDS2, whose predicted product of 942 amino acids is 38% identical in sequence to Zds1p. Zds1p and Zds2p have no detectable homology to known Rho-GAPs or to other known proteins. However, by several assays, it appears that overexpression of either Zds1p or Zds2p decreases the level of Cdc42p activity. Deletion analysis also suggests that Zds1p and Zds2p are at least partially overlapping in function. Deletion of ZDS2 produced no obvious phenotype, and deletion of ZDS1 produced no obvious phenotype other than a mild effect on cell shape. However, the zds1 zds2 double mutant grew slowly with an apparent mitotic delay and produced elongated cells and buds with other evidence of abnormal morphogenesis. A glutathione S-transferase-Zds1p fusion protein that fully complemented the double mutant localized to presumptive bud sites and the tips of small buds. The similarity of this localization to that of Cdc42p suggests that Zds1p may interact directly with Cdc42p. As ZDS1 and ZDS2 have recently been identified also by numerous other groups studying a wide range of biological phenomena, the roles of Cdc42p in intracellular signaling may be more diverse than has previously been appreciated.
Quelles interventions les infirmières dans un milieu hospitalier doivent-elles mobiliser pour maintenir ou renforcer l'espoir des jeunes adultes (25-35 ans) suite à l'annonce d'un diagnostic de cancer ?
Creators: name: Nein, Geraldine
name: Pistis, Rina
Publisher: name: Unknown
Year: 0
Subjects: subject: milieu hospitalier
subject: cancer
subject: diagnostic
subject: espoir
subject: intervention infirmière
subject: adulte

description: Le jury a relevé que la revue de littérature est très riche et pertinente sur le concept d'espoir utilisant des auteurs importants pour la discipline infirmière.
Adhesion-dependent regulation of an A+U-rich element-binding activity associated with AUF1.
Creators: name: Lofquist, A K
name: DeMaria, C T
name: Haskill, J S
name: Sirenko, O I
name: Morris, J S
name: Brewer, G
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: Monocyte adherence results in the rapid transcriptional activation and mRNA stabilization of numerous mediators of inflammation and tissue repair. While the enhancer and promoter elements associated with transcriptional activation have been studied, mechanisms linking adhesion, mRNA stabilization, and translation are unknown. GROalpha and interleukin-1beta (IL-1beta) mRNAs are highly labile in nonadhered monocytes but stabilize rapidly after adherence. GROalpha and IL-1beta transcripts both contain A+U-rich elements (AREs) in the 3' untranslated region (UTR) which have been directly associated with rapid mRNA turnover. To determine if the GROalpha ARE region was recognized by factors associated with mRNA degradation, we carried out mobility gel shift analyses using a series of RNA probes encompassing the entire GROalpha transcript. Stable complexes were formed only with the proximal 3' UTR which contained the ARE region. The two slower-moving complexes were rapidly depleted following monocyte adherence but not direct integrin engagement. Deadherence reactivated the two largest ARE-binding complexes and destabilized IL-1beta transcripts. Antibody supershift studies demonstrated that both of these ARE RNA-binding complexes contained AUF1. The formation of these complexes and the accelerated mRNA turnover are phosphorylation-dependent events, as both are induced in adherent monocytes by the tyrosine kinase inhibitor genistein and the p38 MAP kinase inhibitor of IL-1beta translation, SK&F 86002. These results demonstrate that cell adhesion and deadhesion rapidly and reversibly modify both cytokine mRNA stability and the RNA-binding complexes associated with AUF1.
Variations in the pulsation and spectral characteristics of OAO 1657-415
Creators: name: Pradhan, Pragati
name: Maitra, Chandreyee
name: Paul, Biswajit
name: Islam, Nazma
name: Paul, B. C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present broad-band pulsation and spectral characteristics of the accreting X-ray pulsar OAO 1657--415 with a 2.2 d long \emph{Suzaku} observation carried out covering its orbital phase range $\sim$ 0.12--0.34, with respect to the mid-eclipse. During the last third of the observation, the X-ray count rate in both the X-ray Imaging Spectrometer (XIS) and the HXD-PIN instruments increased by a factor of more than 10. During this observation, the hardness ratio also changed by a factor of more than 5, uncorrelated with the intensity variations. In two segments of the observation, lasting for $\sim$ 30--50 ks, the hardness ratio is very high. In these segments, the spectrum shows a large absorption column density and correspondingly large equivalent widths of the iron fluorescence lines. We found no conclusive evidence for the presence of a cyclotron line in the broad-band X-ray spectrum with \emph{Suzaku}. The pulse profile, especially in the XIS energy band shows evolution with time but not so with energy. We discuss the nature of the intensity variations, and variations of the absorption column density and emission lines during the duration of the observation as would be expected due to a clumpy stellar wind of the supergiant companion star. These results indicate that OAO 1657--415 has characteristics intermediate to the normal supergiant systems and the systems that show fast X-ray transient phenomena.
description: 10 pages, 10 figures, published in MNRAS
Terminator Habitability: the Case for Limited Water Availability on M-dwarf Planets
Creators: name: Lobo, Ana H.
name: Shields, Aomawa L.
name: Palubski, Igor Z.
name: Wolf, Eric
Publisher: name: arXiv
Year: 2022
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Rocky planets orbiting M-dwarf stars are among the most promising and abundant astronomical targets for detecting habitable climates. Planets in the M-dwarf habitable zone are likely synchronously rotating, such that we expect significant day-night temperature differences, and potentially limited fractional habitability. Previous studies have focused on scenarios where fractional habitability is confined to the substellar or "eye" region, but in this paper we explore the possibility of planets with terminator habitability, defined by the existence of a habitable band at the transition between a scorching dayside and a glacial nightside. Using a global climate model, we show that for water-limited planets it is possible to have scorching temperatures in the "eye" and freezing temperatures on the nightside, while maintaining a temperate climate in the terminator region, due to a reduced atmospheric energy transport. Whereas on water-rich planets, increasing stellar flux leads to increased atmospheric energy transport and a reduction in day-night temperature differences, such that the terminator does not remain habitable once the dayside temperatures approach runaway or moist greenhouse limits. We also show that, while water-abundant simulations may result in larger fractional habitability, they are vulnerable to water loss through cold-trapping on the nightside surface or atmospheric water vapor escape, suggesting that even if planets were formed with abundant water, their climates could become water-limited and subject to terminator habitability.
description: 16 pages, 9 figures, 3 tables, Accepted for publication in The Astronomical Journal
title: Pertinence de trois méthodes non-médicamenteuses de gestion des douleurs procédurales chez le patient souffrant de brûlures graves en milieu hospitalier post-critique
title: intérêt de l'hypnoanalgésie, de la musicothérapie et des stratégies de réduction du stress dans le développement de la profession infirmière
titleType: Subtitle
Creators: name: Guerne, Cécile
name: Frascoia, Céline
Publisher: name: Unknown
Year: 0
Subjects: subject: brûlure
subject: douleur
subject: milieu hospitalier
subject: profession infirmière
subject: hypnose
subject: musicothérapie
subject: relaxation
subject: respiration

description: Le jury a relevé la pertinence de la méthodologie, le choix du sujet comme problématique récurrente ainsi que la richesse de la revue de littérature.
title: SouthPAN Video - Aviation
Creators: name: V., Rooke
name: Geoscience Australia
Publisher: name: Commonwealth of Australia (Geoscience Australia)
Year: 2023
Subjects: subject: EARTH SCIENCES
subject: Positioning
subject: SBAS
subject: Satellite-Based Augmentation System
subject: Published_External

description: A short video demonstrating how Geoscience Australia through SouthPAN is bringing benefits to the aviation sector.
Geometrodynamical description of two-dimensional electrodynamics
Creators: name: Sobreiro, Rodrigo F.
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Two-dimensional pure electrodynamics is mapped into two-dimensional gravity in the first order formalism at classical and quantum levels. Due to the fact that the degrees of freedom of these two theories do not match, we are enforced to introduce extra fields from the beginning. These fields are introduced through a BRST exact boundary term, so they are harmless to the physical content of the theory. The map between electromagnetism and gravity fields generate a non-trivial Jacobian, which brings extra features (but also harmless to the physical content of the gravity theory) at quantum level.
description: 14 pages. No figures. Final version to be published in the Europhysics Letters
Towards topological fixed-point models beyond gappable boundaries
Creators: name: Bauer, Andreas
name: Eisert, Jens
name: Wille, Carolin
Publisher: name: arXiv
Year: 2021
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Quantum Algebra (math.QA)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We consider fixed-point models for topological phases of matter formulated as discrete path integrals in the language of tensor networks. Such zero-correlation length models with an exact notion of topological invariance are known in the mathematical community as state-sum constructions or lattice topological quantum field theories. All of the established ansatzes for fixed-point models imply the existence of a gapped boundary as well as a commuting-projector Hamiltonian. Thus, they fail to capture topological phases without a gapped boundary or commuting-projector Hamiltonian, most notably chiral topological phases in $2+1$ dimensions. In this work, we present a more general fixed-point ansatz not affected by the aforementioned restrictions. Thus, our formalism opens up a possible way forward towards a microscopic fixed-point description of chiral phases and we present several strategies that may lead to concrete examples. Furthermore, we argue that our more general ansatz constitutes a universal form of topological fixed-point models, whereas established ansatzes are universal only for fixed-points of phases which admit topological boundaries.
description: v4: version accepted for publication in PRB
title: SouthPAN Video - Consumer
Creators: name: V., Rooke
name: Geoscience Australia
Publisher: name: Commonwealth of Australia (Geoscience Australia)
Year: 2023
Subjects: subject: EARTH SCIENCES
subject: Positioning
subject: SBAS
subject: Satellite-Based Augmentation System
subject: Published_External

description: A short video demonstrating how Geoscience Australia through SouthPAN is bringing benefits to people with vision impairment.
title: Altération de l'image corporelle chez l'enfant brûlé
title: accompagnement en vue de sa réhabilitation psychosociale
titleType: Subtitle
Creators: name: Esteve, Lara
name: Volet, Laila
Publisher: name: Unknown
Year: 0
Subjects: subject: brûlure
subject: enfant
subject: image
subject: corps
subject: accompagnement
subject: milieu hospitalier
subject: pluridisciplinarité
subject: rôle infirmier

description: Le jury a relevé la qualité des articles scientifiques analysés.
The resettlement experiences of South Sudanese refugees in Australia 2000-2010: An ethnographic case study
Creators: name: WOUL, GAK DENG
Publisher: name: Monash University
Year: 2023
Subjects: classificationCode: 480704
subject: Migration, asylum and refugee law

description: This PhD investigated the resettlement experiences of South Sudanese refugees in Australia in 2000-2010. It was undertaken at a time when Australia was continuing to debate its responsibilities for accepting and supporting the resettlement of refugees from across the world, including South Sudan. The study drew on ethnographic data from interviews with and narratives of South Sudanese refugees who arrived in Australia in 2000-2010. Findings highlight the rich diversity of capitals, capacities and needs of South Sudanese refugees when they arrived in Australia. The study argues for the importance of genuinely shared responsibility in supporting South Sudanese refugees’ resettlement experiences.
Quelles données ou modèles théoriques probants favorisent la participation des parents et le bon développement du prématuré dans une perspective de qualité des soins
Creators: name: Dutoit, Geneviève
Publisher: name: Unknown
Year: 0
Subjects: subject: prématuré
subject: développement physiologique
subject: partenariat
subject: relation soignant-famille
subject: qualité des soins
subject: rôle infirmier

description: Le jury a relevé la rigueur méthodologique ainsi que l'intérêt et l'actualité de l'objet d'étude.
title: SouthPAN Video - Construction
Creators: name: V., Rooke
name: Geoscience Australia
Publisher: name: Commonwealth of Australia (Geoscience Australia)
Year: 2023
Subjects: subject: EARTH SCIENCES
subject: Positioning
subject: SBAS
subject: Satellite-Based Augmentation System
subject: Published_External

description: A short video demonstrating how Geoscience Australia through SouthPAN is bringing benefits to the construction sector.
Relativistic strong-field ionization of hydrogen-like atomic systems in constant crossed electromagnetic fields
Creators: name: Eckey, A.
name: Klaiber, M.
name: Voitkiv, A. B.
name: Müller, C.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: Relativistic strong-field ionization of hydrogen-like atoms or ions in a constant crossed electromagnetic field is studied. The transition amplitude is formulated within the strong-field approximation in Göppert-Mayer gauge, with initial and final electron states being described by the corresponding Dirac-Coulomb and Dirac-Volkov wave functions, respectively. Coulomb corrections to the electron motion during tunneling are taken into account by adjusting an established method to the present situation. Total and energy-differential ionization rates are calculated and compared with predictions from other theories in a wide range of atomic numbers and applied field strengths.
description: 9 pages, 4 figures
The HI Chronicles of LITTLE THINGS BCDs II: The Origin of IC 10's HI Structure
Creators: name: Ashley, Trisha
name: Elmegreen, Bruce G.
name: Johnson, Megan
name: Nidever, David L.
name: Simpson, Caroline E.
name: Pokhrel, Nau Raj
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: In this paper we analyze Very Large Array (VLA) telescope and Green Bank Telescope (GBT) atomic hydrogen (HI) data for the LITTLE THINGS(1) blue compact dwarf galaxy IC 10. The VLA data allow us to study the detailed HI kinematics and morphology of IC 10 at high resolution while the GBT data allow us to search the surrounding area at high sensitivity for tenuous HI. IC 10's HI appears highly disturbed in both the VLA and GBT HI maps with a kinematically distinct northern HI extension, a kinematically distinct southern plume, and several spurs in the VLA data that do not follow the general kinematics of the main disk. We discuss three possible origins of its HI structure and kinematics in detail: a current interaction with a nearby companion, an advanced merger, and accretion of intergalactic medium. We find that IC 10 is most likely an advanced merger or a galaxy undergoing accretion. 1:Local Irregulars That Trace Luminosity Extremes, The HI Nearby Galaxy Survey; https://science.nrao.edu/science/surveys/littlethings
description: 36 pages, 17 figures, accepted for publication in The Astronomical Journal
title: SouthPAN Video - Maritime
Creators: name: V., Rooke
name: D., Warouw
Publisher: name: Commonwealth of Australia (Geoscience Australia)
Year: 2023
Subjects: subject: SBAS
subject: Positioning
subject: Satellite-Based Augmentation System
subject: EARTH SCIENCES
subject: Published_External

description: A short video demonstrating how Geoscience Australia through SouthPAN is bringing benefits to the maritime sector.
Space-time hp finite elements for heat evolution in laser-based additive manufacturing
Creators: name: Kopp, Philipp
name: Calo, Victor
name: Rank, Ernst
name: Kollmannsberger, Stefan
Publisher: name: arXiv
Year: 2021
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: The direct numerical simulation of metal additive manufacturing processes such as laser powder bed fusion is challenging due to the vast differences in spatial and temporal scales. Classical approaches based on locally refined finite elements combined with time-stepping schemes can only address the spatial multi-scale nature and provide only limited scaling potential for massively parallel computations. We address these shortcomings in a space-time Galerkin framework where the finite element interpolation also includes the temporal direction. In this setting, we construct four-dimensional meshes that are locally refined towards the laser spot and allow for varying temporal accuracy depending on the position in space. By splitting the mesh into conforming time slabs, we recover a stepwise solution to solve the space-time problem locally in time at this slab; additionally, we can choose time-slab sizes significantly larger than classical time-stepping schemes. As a result, we believe this setting to be well suited for large-scale parallelization. In our work, we use a continuous Galerkin-Petrov formulation of the nonlinear heat equation with an apparent heat capacity model to account for the phase change. We validate our approach by computing the AMB2018-02 benchmark, where we obtain an excellent agreement with the measured melt pool shape. Using the same setup, we demonstrate the performance potential of our approach by hatching a square area with a laser path length of about one meter.
Path-by-path uniqueness of multidimensional SDE's on the plane with nondecreasing coefficients
Creators: name: Bogso, Antoine-Marie
name: Dieye, Moustapha
name: Menoukeu-Pamen, Olivier
Publisher: name: arXiv
Year: 2021
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60H05, 60H15

description: In this paper we study path-by-path uniqueness for multidimensional stochastic differential equations driven by the Brownian sheet. We assume that the drift coefficient is unbounded, verifies a spatial linear growth condition and is componentwise nondeacreasing. Our approach consists of showing the result for bounded and componentwise nondecreasing drift using both a local time-space representation and a law of iterated logarithm for Brownian sheets. The desired result follows using a Gronwall type lemma on the plane. As a by product, we obtain the existence of a unique strong solution of multidimensional SDEs driven by the Brownian sheet when the drift is non-decreasing and satisfies a spatial linear growth condition.
description: 24 pages
CCAAT-binding factor NF-Y and RFX are required for in vivo assembly of a nucleoprotein complex that spans 250 base pairs: the invariant chain promoter as a model.
Creators: name: Ting, J P
name: Linhoff, M W
name: Wright, K L
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: The events that lead to promoter accessibility within chromatin are not completely understood. The invariant chain (Ii) promoter was used as a model to determine the contribution of different DNA-binding factors in establishing occupancy of a complex promoter. Gamma interferon induction of the Ii promoter requires the cooperation of multiple cis elements including distal S, X, and Y/CCAAT elements along with proximal GC and Y/CCAAT elements. The heteromeric transcription factor NF-Y binds to both Y/CCAAT elements. Genomic footprinting was used to analyze in vivo protein-DNA contacts for integrated Ii promoters bearing mutations in each element. The results reveal a hierarchy of transcription factor loading with NF-Y binding to the distal Y/CCAAT element being required for establishing protein-DNA interactions over the entire 250 bp analyzed. Mutation of the X box disrupts binding primarily at the adjacent Y/CCAAT element along with a lesser effect on GC box binding. Importantly, this finding is verified with a cell line which lacks a functional X-box-binding factor, RFX, providing physiological validity for the strategy described here. Mutation of both the S element and the GC box results in either no or little effect on transcription factor binding. However, mutation of the proximal Y/CCAAT element disrupts binding to the adjacent GC box and partially reduces binding in the distal S/X/Y domain. The crucial role for NF-Y in establishing promoter occupancy may be related to its histone fold motif, the essential component for assembling nucleosome-like structures.
Cooperative binding interactions required for function of the Ty1 sterile responsive element.
Creators: name: Esch, R K
name: Errede, B
name: Baur, M
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: The Ste12p transcription factor controls the expression of Ty1 transposable element insertion mutations and genes whose products are required for mating in Saccharomyces cerevisiae. The binding site for Ste12p is a consensus DNA sequence known as a pheromone response element (PRE). Upstream activating sequences (UASs) derived from known Ste12p-dependent genes have previously been characterized to require either multiple PREs or a single PRE coupled to a binding site for a second protein. The Ste12p-dependent UAS from Ty1, called a sterile response element (SRE), is of the second type and is comprised of a PRE and an adjacent TEA (TEF-1, Tec1, and AbaA motif) DNA consensus sequence (TCS). In this report, we show by UV cross-linking analysis that two proteins, Ste12p and a protein with an apparent size of 72 kDa, directly contact the Ty1 SRE. Other experiments show that Tec1p is required for formation of the Ty1 SRE protein-DNA complex and is physically present in the complex. These results establish a direct role for Tec1p in the Ty1 SRE and yet another set of combinatorial interactions that achieve a qualitatively distinct mode of transcriptional regulation with Ste12p.
Coordination of the mating and cell integrity mitogen-activated protein kinase pathways in Saccharomyces cerevisiae.
Creators: name: Buehrer, B M
name: Errede, B
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: Mating pheromone stimulates a mitogen-activated protein (MAP) kinase activation pathway in Saccharomyces cerevisiae that induces cells to differentiate and form projections oriented toward the gradient of pheromone secreted by a mating partner. The polarized growth of mating projections involves new cell wall synthesis, a process that relies on activation of the cell integrity MAP kinase, Mpk1. In this report, we show that Mpk1 activation during pheromone induction requires the transcriptional output of the mating pathway and protein synthesis. Consequently, Mpk1 activation occurs subsequent to the activation of the mating pathway MAP kinase cascade. Additionally, Spa2 and Bni1, a formin family member, are two coil-coil-related proteins that are involved in the timing and other aspects of mating projection formation. Both proteins also affect the timing and extent of Mpk1 activation. This correlation suggests that projection formation comprises part of the pheromone-induced signal that coordinates Mpk1 activation with mating differentiation. Stimulation of Mpk1 activity occurs through the cell integrity phosphorylation cascade and depends on Pkc1 and the redundant MAP/Erk kinases (MEKs), Mkk1 and Mkk2. Surprisingly, Mpk1 activation by pheromone was only partially impaired in cells lacking the MEK kinase Bck1. This Bck1-independent mechanism reveals the existence of an alternative activator of Mkk1/Mkk2 in some strain backgrounds that at least functions under pheromone-induced conditions.
Rapid Rehabilitation Nursing in Surgical Patients: a Scoping Review Protocol
Creators: name: da Silva Xavier Fialho, Joana
name: Ferreira, Bruno
name: Ribeiro, Luís
name: Silva, Paulo
name: de Sousa, Luís
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Nursing
subject: FOS: Health sciences
subject: Medicine and Health Sciences
subject: #Nursing
subject: Perioperative
subject: #Rapid Rehabilitation Nursing
subject: #Rehabilitation Nursing
subject: #Scoping Review
subject: #Surgical Patient

description: Mapping of the knowledge about the application of rapid rehabilitation nursing in surgical patients.
Pinching instabilities in superconducting strings
Creators: name: Battye, R. A.
name: Cotterill, S. J.
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Superconducting cosmic strings can exhibit longitudinal, pinching instabilities in some regions of the parameter space. We make predictions about the onset of this instability using the thin string approximation (TSA) and develop an improved analysis that remains applicable for small wavelength perturbations, where the TSA breaks down. We use simulations of perturbed strings to assess the accuracy of the TSA, test the predictions of our new analysis and demonstrate an improvement over previous methods in the literature. Notably, it appears that the instabilities are typically present for a larger range of magnetic strings than previously expected, and we show examples of pinching instabilities also occurring in electric strings. However, both our simulations and predictions agree that strings near the chiral limit are free from pinching instabilities and in particular our results support our previously published claim that vortons can be stable to all classical perturbations if they are sufficiently large.
description: 14 pages, 7 figures
The Linear Template Fit
Creators: name: Britzger, Daniel
Publisher: name: arXiv
Year: 2021
Subjects: subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Applications (stat.AP)
subject: Methodology (stat.ME)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: The estimation of parameters from data is a common problem in many areas of the physical sciences, and frequently used algorithms rely on sets of simulated data which are fit to data. In this article, an analytic solution for simulation-based parameter estimation problems is presented. The matrix formalism, termed the Linear Template Fit, calculates the best estimators for the parameters of interest. It combines a linear regression with the method of least squares. The algorithm uses only predictions calculated for a few values of the parameters of interest, which have been made available prior to its execution. The Linear Template Fit is particularly suited for performance critical applications and parameter estimation problems with computationally intense simulations, which are otherwise often limited in their usability for statistical inference. Equations for error propagation are discussed in detail and are given in closed analytic form. For the solution of problems with a nonlinear dependence on the parameters of interest, the Quadratic Template Fit is introduced. As an example application, a determination of the strong coupling constant from inclusive jet cross section data at the CERN Large Hadron Collider is studied and compared with previously published results.
description: 47 pages, 11 figures, 3 tables, including minor changes during journal review
title: Brief von Peter Wagner an Josef Steindl
Creators: name: Wagner, Peter
Year: 2017

description: Mit handschriftlichen Grußworten des Verfassers und handschriftlichen Notizen von Josef Steindl auf der Voder- sowie Rückseite.
description: Typoskript mit Unterschrift, 1 Blatt, 2 Seiten
On the Numerical Dispersion of Electromagnetic Particle-In-Cell Code : Finite Grid Instability
Creators: name: Meyers, M. D.
name: Huang, C. -K.
name: Zeng, Y.
name: Yi, S. A.
name: Albright, B. J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: The Particle-In-Cell (PIC) method is widely used in relativistic particle beam and laser plasma modeling. However, the PIC method exhibits numerical instabilities that can render unphysical simulation results or even destroy the simulation. For electromagnetic relativistic beam and plasma modeling, the most relevant numerical instabilities are the finite grid instability and the numerical Cherenkov instability. We review the numerical dispersion relation of the electromagnetic PIC algorithm to analyze the origin of these instabilities. We rigorously derive the faithful 3D numerical dispersion of the PIC algorithm, and then specialize to the Yee FDTD scheme. In particular, we account for the manner in which the PIC algorithm updates and samples the fields and distribution function. Temporal and spatial phase factors from solving Maxwell's equations on the Yee grid with the leapfrog scheme are also explicitly accounted for. Numerical solutions to the electrostatic-like modes in the 1D dispersion relation for a cold drifting plasma are obtained for parameters of interest. In the succeeding analysis, we investigate how the finite grid instability arises from the interaction of the numerical 1D modes admitted in the system and their aliases. The most significant interaction is due critically to the correct represenation of the operators in the dispersion relation. We obtain a simple analytic expression for the peak growth rate due to this interaction.
description: 25 pages, 6 figures
title: SouthPAN Video - Resources
Creators: name: V., Rooke
Publisher: name: Commonwealth of Australia (Geoscience Australia)
Year: 2023
Subjects: subject: EARTH SCIENCES
subject: Positioning
subject: SBAS
subject: Satellite-Based Augmentation System
subject: Published_External

description: A short video demonstrating how Geoscience Australia through SouthPAN is bringing benefits to the resources sector.
Goal-oriented adaptive finite element method for semilinear elliptic PDEs
Creators: name: Becker, Roland
name: Brunner, Maximilian
name: Innerberger, Michael
name: Melenk, Jens Markus
name: Praetorius, Dirk
Publisher: name: arXiv
Year: 2021
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: We formulate and analyze a goal-oriented adaptive finite element method (GOAFEM) for a semilinear elliptic PDE and a linear goal functional. The strategy involves the finite element solution of a linearized dual problem, where the linearization is part of the adaptive strategy. Linear convergence and optimal algebraic convergence rates are shown.
Identification of tumor-specific paclitaxel (Taxol)-responsive regulatory elements in the interleukin-8 promoter.
Creators: name: Ting, J P
name: Matsushima, K
name: Lee, L F
name: Mukaida, N
name: Haskill, J S
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: Paclitaxel (Taxol) is a novel chemotherapeutic drug that is effective against breast and ovarian cancers. Although the primary target of paclitaxel is microtubules, its efficacy exceeds that of conventional microtubule-disrupting agents, suggesting that it may have additional cellular effects. Previously, we demonstrated that paclitaxel can induce interleukin-8 (IL-8) gene expression at the transcriptional level in subsets of human ovarian cancer lines. In this as well as the previous report, we present evidence that this ability is not linked to the lipopolysaccharide pathway of IL-8 gene induction. The present study identifies the cis-acting elements and trans-acting factors involved in this induction by transfecting DNA constructs containing the 5'-flanking region of the IL-8 gene linked to the chloramphenicol acetyltransferase reporter gene into paclitaxel-responsive and nonresponsive ovarian cancer cells (responsiveness refers to the IL-8 response). Paclitaxel only activated the IL-8 promoter in responsive cells. The AP-1 and NF-kappaB binding sites in the IL-8 promoter are required for activation by paclitaxel; in contrast, a C/EBP site required for IL-8 promoter activation in other cell types is not involved. Gel shift assays demonstrate that paclitaxel causes a marked increase in protein binding to the NF-kappaB and AP-1 consensus binding sequences in the paclitaxel-responsive ovarian cells, but not the nonresponsive cells. The induction of NF-kappaB and AP-1 binding is reduced by the addition of protein kinase C inhibitors and cyclic AMP effector, respectively. These results demonstrate a molecular mechanism for cell-specific paclitaxel-induced IL-8 gene expression which may have clinical relevance.
title: Les soins développementaux et le rôle infirmier pour agir sur le stress du nouveau-né prématuré
title: quelles stratégies infirmières peut-on mettre en place au sein d'un service de soins intensifs de néonatalogie pour contribuer à diminuer le stress du nouveau-né prématuré lié à son environnement afin de promouvoir son développement ?
titleType: Subtitle
Creators: name: Burdet, Julie
name: Gachet, Joy
Publisher: name: Unknown
Year: 0
Subjects: subject: nouveau-né
subject: prématuré
subject: stress
subject: développement physiologique
subject: soins intensifs
subject: rôle infirmier
subject: néonatologie

description: Le jury a relevé que le questionnement sur le rôle professionnel est très présent et la problématique des soins développementaux et leurs implantations sont d'actualité.
L'utilisation et l'efficacité de l'hypnose dans le champ de la douleur aiguë, dans le domaine infirmier
Creators: name: Buenter Markwalder, Luzia
name: Chenuz, Emilie
Publisher: name: Unknown
Year: 0
Subjects: subject: soins infirmiers
subject: milieu hospitalier
subject: douleur
subject: hypnose

description: Le jury a relevé que la thématique d'actualité est bien explorée.
Initiation of DNA interstrand cross-link repair in humans: the nucleotide excision repair system makes dual incisions 5' to the cross-linked base and removes a 22- to 28-nucleotide-long damage-free strand.
Creators: name: Mu, D
name: Bessho, T
name: Sancar, A
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: Most DNA repair mechanisms rely on the redundant information inherent to the duplex to remove damaged nucleotides and replace them with normal ones, using the complementary strand as a template. Interstrand cross-links pose a unique challenge to the DNA repair machinery because both strands are damaged. To study the repair of interstrand cross-links by mammalian cells, we tested the activities of cell extracts of wild-type or excision repair-defective rodent cell lines and of purified human excision nuclease on a duplex with a site-specific cross-link. We found that in contrast to monoadducts, which are removed by dual incisions bracketing the lesion, the cross-link causes dual incisions, both 5' to the cross-link in one of the two strands. The net result is the generation of a 22- to 28-nucleotide-long gap immediately 5' to the cross-link. This gap may act as a recombinogenic signal to initiate cross-link removal.
Le réconfort en psychiatrie
Creators: name: Marques Duarte, Suzy
name: Vivien, Charlène
Publisher: name: Unknown
Year: 0
Subjects: subject: soins infirmiers en psychiatrie
subject: malade mental
subject: hospitalisation
subject: relation soignant-soigné
subject: accompagnement
subject: rôle infirmier

description: Le jury a relevé l'originalité et la structure du travail.
A Universal Mirror-stacking Approach for Constructing Topological Bound States in the Continuum
Creators: name: Liu, Luohong
name: Li, Tianzi
name: Zhang, Qicheng
name: Xiao, Meng
name: Qiu, Chunyin
Publisher: name: arXiv
Year: 2022
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Bound states in the continuum (BICs) are counter-intuitive localized states with eigenvalues embedded in the continuum of extended states. Recently, nontrivial band topology is exploited to enrich the BIC physics, resulted in topological BICs (TBICs) with extraordinary robustness against perturbations or disorders. Here, we propose a simple but universal mirror-stacking approach to turn nontrivial bound states of any topological monolayer model into TBICs. Physically, the mirror-stacked bilayer Hamiltonian can be decoupled into two independent subspaces of opposite mirror parities, each of which directly inherits the energy spectrum information and band topology of the original monolayer. By tuning the interlayer couplings, the topological bound state of one subspace can move into and out of the continuum of the other subspace continuously without hybridization. As representative examples, we construct one-dimensional first-order and two-dimensional higher-order TBICs, and demonstrate them unambiguously by acoustic experiments. Our findings will expand the research implications of both topological materials and BICs.
description: 5 figures,accepted by Phys.Rev.Lett
New insights on Saturn's formation from its nitrogen isotopic composition
Creators: name: Mousis, Olivier
name: Lunine, Jonathan I.
name: Fletcher, Leigh N.
name: Mandt, Kathleen E.
name: Ali-Dib, Mohamad
name: Gautier, Daniel
name: Atreya, Sushil
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The recent derivation of a lower limit for the $^{14}$N/$^{15}$N ratio in Saturn's ammonia, which is found to be consistent with the Jovian value, prompted us to revise models of Saturn's formation using as constraints the supersolar abundances of heavy elements measured in its atmosphere. Here we find that it is possible to account for both Saturn's chemical and isotopic compositions if one assumes the formation of its building blocks at $\sim$45 K in the protosolar nebula, provided that the O abundance was $\sim$2.6 times protosolar in its feeding zone. To do so, we used a statistical thermodynamic model to investigate the composition of the clathrate phase that formed during the cooling of the protosolar nebula and from which the building blocks of Saturn were agglomerated. We find that Saturn's O/H is at least $\sim$34.9 times protosolar and that the corresponding mass of heavy elements ($\sim$43.1 \Mearth) is within the range predicted by semi-convective interior models.
description: Accepted for publication in Astrophysical Journal Letters