cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Autism risk assessment in siblings of affected children using sex-specific genetic scores
Creators: name: Carayol, Jerome
name: Dombroski, Beth
name: Rousseau, Francis
name: Schellenberg, Gerard D
name: Genin, Emmanuelle
name: Dawson, Geraldine
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: BackgroundThe inheritance pattern in most cases of autism is complex. The risk of autism is increased in siblings of children with autism and previous studies have indicated that the level of risk can be further identified by the accumulation of multiple susceptibility single nucleotide polymorphisms (SNPs) allowing for the identification of a higher-risk subgroup among siblings. As a result of the sex difference in the prevalence of autism, we explored the potential for identifying sex-specific autism susceptibility SNPs in siblings of children with autism and the ability to develop a sex-specific risk assessment genetic scoring system.MethodsSNPs were chosen from genes known to be associated with autism. These markers were evaluated using an exploratory sample of 480 families from the Autism Genetic Resource Exchange (AGRE) repository. A reproducibility index (RI) was proposed and calculated in all children with autism and in males and females separately. Differing genetic scoring models were then constructed to develop a sex-specific genetic score model designed to identify individuals with a higher risk of autism. The ability of the genetic scores to identify high-risk children was then evaluated and replicated in an independent sample of 351 affected and 90 unaffected siblings from families with at least 1 child with autism.ResultsWe identified three risk SNPs that had a high RI in males, two SNPs with a high RI in females, and three SNPs with a high RI in both sexes. Using these results, genetic scoring models for males and females were developed which demonstrated a significant association with autism (P = 2.2 × 10-6 and 1.9 × 10-5, respectively).ConclusionsOur results demonstrate that individual susceptibility associated SNPs for autism may have important differential sex effects. We also show that a sex-specific risk score based on the presence of multiple susceptibility associated SNPs allow for the identification of subgroups of siblings of children with autism who have a significantly higher risk of autism.
Valerio Massimo Felix [poster]
Valerio Massimo Felix [poster]
Valerio Massimo Felix [poster]
Creators: name: Michelazzi, Marika
name: Salvini, Arabella
Publisher: name: M. Michelazzi, A. Salvini, "Valerio Massimo Felix", in Metti la storia al lavoro! Seconda conferenza italiana di Public History. Pisa, 11-15 giugno 2018
Year: 2019

description: Per raccontare Felix abbiamo unito varie competenze (illustrazione e sceneggiatura) alla ricerca storica e alla comunicazione. Abbiamo creato il (fittizio) diario di viaggio di un giovane legionario al seguito di Giulio Cesare nel 59 a.C... La storia della recluta Felix viene raccontata non attraverso un libro, ma “foto per foto”: attraverso i suoi profili social, come se potesse condividere il suo mondo con la facilità dei ragazzi di oggi, dalla famiglia alla paga, dall’accampamento agli incontri coi celti.
How to Handle Assumptions in Synthesis
Creators: name: Bloem, Roderick
name: Ehlers, Rüdiger
name: Jacobs, Swen
name: Könighofer, Robert
Publisher: name: arXiv
Year: 2014
Subjects: subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences

description: The increased interest in reactive synthesis over the last decade has led to many improved solutions but also to many new questions. In this paper, we discuss the question of how to deal with assumptions on environment behavior. We present four goals that we think should be met and review several different possibilities that have been proposed. We argue that each of them falls short in at least one aspect.
description: In Proceedings SYNT 2014, arXiv:1407.4937
Aquatic invertebrate fauna of the Two Peoples Bay area, south-western Australia
Creators: name: Storey, A. W
name: Halse, S. A
name: Shiel, R. J
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

The aquatic invertebrate fauna of four rivers and streams and three lakes in the Two Peoples Bay area, southwestern Australia, was sampled in June 1990 and February 1991. A total of 247 taxa were recorded; 110 in flowing waters, 170 in standing waters and 33 common to both habitats. Increased sampling intensity in February 1991 revealed a diverse microinvertebrate fauna of 47 taxa of Protozoa and Rotifera.The macroinvertebrate fauna was similar to that reported previously from aquatic ecosystems in southwestern Australia. Thirty-six species of microinvertebrates (2 Protozoa, 21 Rotifera, 10 Cladocera and 3 Copepoda) were new records for southwestern Australia, and in many cases, Australia. The number of new records reflects greater sampling and taxonomic effort than has been used previously in southwestern Australia, but also suggest southwestern Australia may have a distinctive microfauna.
X-ray spectroscopic study of BaFeO$_{3}$ thin films; an Fe$ ^{4+}$ ferromagnetic insulator
Creators: name: Tsuyama, T.
name: Matsuda, T.
name: Chakraverty, S.
name: Okamoto, J.
name: Ikenaga, E.
name: Tanaka, A.
name: Mizokawa, T.
name: Hwang, H. Y.
name: Tokura, Y.
name: Wadati, H.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We investigated the electronic and magnetic properties of fully oxidized BaFeO3 thin films, which show ferromagnetic-insulating properties with cubic crystal structure, by hard x-ray photoemission spectroscopy (HAXPES), x-ray absorption spectroscopy (XAS) and soft x-ray magnetic circular dichroism (XMCD). We analyzed the results with configuration-interaction (CI) cluster-model calculations for Fe4+, which showed good agreement with the experimental results. We also studied SrFeO3 thin films, which have an Fe4+ ion helical magnetism in cubic crystal structure, but are metallic at all temperatures. We found that BaFeO3 thin films are insulating with large magnetization (2.1muB/formula unit) under ~ 1 T, using valence-band HAXPES and Fe 2p XMCD, which is consistent with the previously reported resistivity and magnetization measurements. Although Fe 2p core-level HAXPES and Fe 2p XAS spectra of BaFeO3 and SrFeO3 thin films are quite similar, we compared the insulating BaFeO3 to metallic SrFeO3 thin films with valence-band HAXPES. The CI cluster-model analysis indicates that the ground state of BaFeO3 is dominated by d5L (L: ligand hole) configuration due to the negative charge transfer energy, and that the band gap has significant O 2p character. We revealed that the differences of the electronic and magnetic properties between BaFeO3 and SrFeO3 arise from the differences in their lattice constants, through affecting the strength of hybridization and bandwidth.
description: 8 pages, 5 figures
The Maximum Entropy Principle Revisited
Creators: name: Dreyer, Wolfgang
name: Kunik, Matthias
Publisher: name: Weierstrass Institute
Year: 1997
Subjects: subject: maximum entropy principle
subject: dominant particle interaction
subject: free flight
subject: Euler equations
subject: 76P05
subject: 82B40
subject: 80A05
subject: 82D05

description: We study the effect of the Maximum Entropy Principle (MEP) on the thermodynamic behaviour of gases. The MEP relies on the kinetic theory of gases and yields the local constitutive equations of Extended Thermodynamics. There are two extreme cases on the scale of the kinetic theory: Dominance of particle interactions and free flight. In its current form the MEP gives the phase density that maximizes the entropy at each instant of time. This is appropriate in case of dominant particle interaction but it is not adequate for free flight. Here we introduce a modified MEP that is capable to link both extreme cases. To illustrate the way the modified MEP works, we consider an example which leads in the case of dominant particle interactions to the Euler equations. In addition there results a representation theorem that contains the global solutions of the Euler equations with all shock interactions for arbitrary large variations of the initial data.
HCN ice in Titan's high-altitude southern polar cloud
Creators: name: de Kok, Remco J.
name: Teanby, Nicholas A.
name: Maltagliati, Luca
name: Irwin, Patrick G. J.
name: Vinatier, Sandrine
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Titan's middle atmosphere is currently experiencing a rapid change of season after northern spring arrived in 2009. A large cloud was observed for the first time above Titan's southern pole in May 2012, at an altitude of 300 km. This altitude previously showed a temperature maximum and condensation was not expected for any of Titan's atmospheric gases. Here we show that this cloud is composed of micron-sized hydrogen cyanide (HCN) ice particles. The presence of HCN particles at this altitude, together with new temperature determinations from mid-infrared observations, indicate a very dramatic cooling of Titan's atmosphere inside the winter polar vortex in early 2012. Such a cooling is completely contrary to previously measured high-altitude warming in the polar vortex, and temperatures are a hundred degrees colder than predicted by circulation models. Besides elucidating the nature of Titan's mysterious polar cloud, these results thus show that post-equinox cooling at the winter pole is much more efficient than previously thought.
description: Published in Nature on 2 October 2014. This is the author version, before final editing by Nature
Additional file 1 of MediQuit – an electronic deprescribing tool: a pilot study in German primary care; GPs’ and patients’ perspectives
Creators: name: Michiels-Corsten, Matthias
name: Gerlach, Navina
name: Junius-Walker, Ulrike
name: Schleef, Tanja
name: Donner-Banzhoff, Norbert
name: Viniol, Annika
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: Additional file 1.
Undeclared Work among Ukrainian Refugees: Prevalence and Explanations
Creators: name: Giesing, Yvonne
name: Chargaziia, Lasha
name: Poutvaara, Panu
name: Weber, Nina
name: Necker, Sarah
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Social and Behavioral Sciences

description: The war in Ukraine has led to the largest refugee movement within Europe since World War II, presenting European countries with new challenges and opportunities. Successful integration policies are crucial and can ease the pressure from demographic change in the host countries. In this project, we study a potential obstacle to the successful integration of Ukrainian refugees – undeclared work. Due to difficulties with integration and lack of recognition of educational qualifications refugees may decide to engage in undeclared work. The aim of our project is to estimate the extent of participation and reasons why Ukrainian refugees participate in undeclared work, with the aim of identifying potential ways to prevent refugees from doing so. We use a survey among refugees in Europe.
Compensatory Evolution in RNA Secondary Structures Increases Substitution Rate Variation among Sites
Creators: name: Knies, J. L.
name: Hoffman, N. G.
name: Burch, C. L.
name: Swanstrom, R.
name: Vision, T. J.
name: Dang, K. K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: There is growing evidence that interactions between biological molecules (e.g., RNA–RNA, protein–protein, RNA–protein) place limits on the rate and trajectory of molecular evolution. Here, by extending Kimura's model of compensatory evolution at interacting sites, we show that the ratio of transition to transversion substitutions (κ) at interacting sites should be equal to the square of the ratio at independent sites. Because transition mutations generally occur at a higher rate than transversions, the model predicts that κ should be higher at interacting sites than at independent sites. We tested this prediction in 10 RNA secondary structures by comparing phylogenetically derived estimates of κ in paired sites within stems (κp) and unpaired sites within loops (κu). Eight of the 10 structures showed an excellent match to the quantitative predictions of the model, and 9 of the 10 structures matched the qualitative prediction κp > κu. Only the Rev response element from the human immunovirus (HIV) genome showed the reverse pattern, with κp < κu. Although a variety of evolutionary forces could produce quantitative deviations from the model predictions, the reversal in magnitude of κp and κu could be achieved only by violating the model assumption that the underlying transition (or transversion) mutation rates were identical in paired and unpaired regions of the molecule. We explore the ability of the APOBEC3 enzymes, host defense mechanisms against retroviruses, which induce transition mutations preferentially in single-stranded regions of the HIV genome, to explain this exception to the rule. Taken as a whole, our findings suggest that κ may have utility as a simple diagnostic to evaluate proposed secondary structures.
Biofilm development and extracellular enzyme activities on wood in billabongs of south-eastern Australia
Creators: name: Scholz, Oliver
name: Boon, Paul I
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

1. The accrual of organic matter, chlorophyll a and bacteria, and the activities of various extracellular enzymes were studied during biofilm formation on River Red Gum (Eucalyptus camaldulensis) wood submerged in two temperate Australian billabongs for 24 weeks over summer and winter of 1989–90.2. Peak organic matter content of the biofilm ranged from 0.7 to 3.3mg AFDW cm−2, chlorophyll a content from 1.3 to 4. 2μg cm−2 and bacterial abundance from 18 × 106 to 94 × 106 cells cm−2. Most variation in organic matter content, chlorophyll a content and bacterial abundance in the biofilms couid be attributed to the duration of immersion (28–48% of variation) and to the interaction between site and submergence period (11–12%). Differences between sites and between seasons were less important in explaining total variation.3. Alkaline phosphatase, aminopeptidase and [3-D-glucosidase activities, determined per unit substratum surface area, were up to 138 ± 26 nmol cm−2h−1, 113 ± 1 nmol cm−2h−1 and 9.3 ± 2.2 nmol cm−2h−1, respectively. Activities of these three enzymes determined per unit organic biomass were up to 203 ± 25, 157 ± 13, and 16 ± 2.1 nmol mg1 AFDW h−1 respectively. Enzyme activities expressed on an area- or biomass-specific basis responded differently to the effects of season, site and duration of substratum exposure.4. Few consistent relationships could be established between the activity of a given enzyme system and the activity of other enzymes, nor with the various biomass parameters, such as total organic matter content, chlorophyll a content or bacterial abundance.5. We suggest that submerged wood of the River Red Gum is an important site for biofilm development in lentic systems in south-eastern Australia, and thus as a food resource for grazing invertebrates and for transformations of various nutrients and organic matter.
Natural Selection against Protein Aggregation on Self-Interacting and Essential Proteins in Yeast, Fly, and Worm
Creators: name: Chen, Y.
name: Dokholyan, N. V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Protein aggregation is the phenomenon of protein self-association potentially leading to detrimental effects on physiology, which is closely related to numerous human diseases such as Alzheimer's and Parkinson's disease. Despite progress in understanding the mechanism of protein aggregation, how natural selection against protein aggregation acts on subunits of protein complexes and on proteins with different contributions to organism fitness remains largely unknown. Here, we perform a proteome-wide analysis by using an experimentally validated algorithm TANGO and utilizing sequence, interactomic and phenotype-based functional genomic data from yeast, fly, and nematode. We find that proteins that are capable of forming homooligomeric complex have lower aggregation propensity compared with proteins that do not function as homooligomer. Further, proteins that are essential to the fitness of an organism have lower aggregation propensity compared with nonessential ones. Our finding suggests that the selection force against protein aggregation acts across different hierarchies of biological system.
About a one-dimensional stationary Schrödinger-Poisson system with Kohn-Sham potential
Creators: name: Kaiser, Hans-Christoph
name: Rehberg, Joachim
Publisher: name: Weierstrass Institute
Year: 1997
Subjects: subject: stationary Schrödinger-Poisson system
subject: Kohn-Sham system
subject: Schrödinger operator with mixed boundary conditions
subject: quantum mechanical particle density operator
subject: nonlinear Poisson equations
subject: simulation of electronic devices
subject: electron gas with reduced dimension
subject: nanoelectronics
subject: 35B45
subject: 35D05
subject: 35D10
subject: 35J05
subject: 35J10
subject: 35J20
subject: 35J60
subject: 35J65
subject: 35Q40
subject: 47A55
subject: 47A60
subject: 47A75
subject: 47H05
subject: 47H10
subject: 47H15

description: The stationary Schrödinger-Poisson system with a self-consistent effective Kohn-Sham potential is a system of PDEs for the electrostatic potential and the envelopes of wave functions defining the quantum mechanical carrier densities in a semiconductor nano-structure. We regard both Poisson's and Schrödinger's equation with mixed boundary conditions and discontinuous coefficients. Without an exchange-correlation potential the Schrödinger-Poisson system is a nonlinear Poisson equation in the dual of a Sobolev space which is determined by the boundary conditions imposed on the electrostatic potential. The nonlinear Poisson operator involved is strongly monotone and boundedly Lipschitz continuous, hence the operator equation has a unique solution. The proof rests upon the following property: the quantum mechanical carrier density operator depending on the potential of the defining Schrödinger operator is anti-monotone and boundedly Lipschitz continuous. The solution of the Schrödinger-Poisson system without an exchange-correlation potential depends boundedly Lipschitz continuous on the reference potential in Schrödinger's operator. By means of this relation a fixed point mapping for the vector of quantum mechanical carrier densities is set up which meets the conditions in Schauder's fixed point theorem. Hence, the Kohn-Sham system has at least one solution. If the exchange-correlation potential is sufficiently small, then the solution of the Kohn-Sham system is unique. Moreover, properties of the solution as bounds for its values and its oscillation can be expressed in terms of the data of the problem. The one-dimensional case requires special treatment, because in general the physically relevant exchange-correlation potentials are not Lipschitz continuous mappings from the space L1 into L2, but into L1.
Preparing product teams for industry 4.0: development of a process & supporting toolkit for early-stage decision-making in mass customisation
Creators: name: O’Sullivan, Michael
Publisher: name: University of Limerick
Year: 2023
Subjects: Engineering

description: Advances in manufacturing and supply chain technologies have led to a resurgence in the popularity of mass customisation (MC), the concept of producing custom products at a scale and efficiency near that of mass production. However, product teams attempting to leverage MC are experiencing high failure rates as they struggle to understand the level of customisation – if any – that their product should offer. This could be solved by finding the point of intersection between the customer’s perceived monetary value of being able to customise a given product, and the cost of implementing it. While the need for such a mass customisation decision process (MCDP) was identified over two decades ago, it still appears to be unaddressed today. This research proposes such a process, leveraging tools like the Kano Model, Quality Function Deployment and the ‘serious game,’ Buy a Feature. It was developed through an action research approach with 77 new product development student projects, before being tested in a business setting by two start-up companies. In testing and developing this decision process, this research also provides insights on the types of products that appear to be most and least suited to mass customisation. The findings highlight how easy it is to assume that customisation might be a valuable addition to a product, when in most cases it is not something for which customers are willing to pay a sufficient amount. In cases where it is worth offering, the process helps to identify a suitable level of customisation early enough to allow for appropriate design and manufacturing methods to be exploited. Finally, previously undocumented user experience (UX) issues relating to the tools used in the MCDP were uncovered during this testing and a toolkit was iteratively developed to overcome them. This toolkit makes the MCDP easy to learn and apply for both students and companies, and these two research outputs together form the starting point of a proposed end-to-end framework and supporting software for the successful implementation of MC.
Brief an Fiorentino
Creators: name: Halévy, Fromental
Publisher: name: [s.n.]
Year: 1879

description: von F[romental] Halévy
description: Französisch
description: Den Brief erhielt Cäsar von Arx gemäss beiliegenden Notizen von Karl Geigy-Hagenbach geschenkt.
description: Verzeichnung=Description=Inventaire November 2016 Neuaufnahme HBr
Edge Asymptotics for the Radiosity Equation over Polyhedral Boundaries
Creators: name: Rathsfeld, Andreas
Publisher: name: Weierstrass Institute
Year: 1997
Subjects: subject: radiosity equation
subject: edge asymptotics
subject: 45A05

description: In the present paper we consider the radiosity equation over the boundary of a polyhedral domain. Similarly to corresponding results on the double layer potential equation, the solution of the second kind integral equation with non-compact integral operator is piecewise continuous. The partial derivatives, however, are not bounded. In the present paper we derive the first term in the asymptotic expansion of the solution in the vicinity of an edge. Note that, knowing this term, optimal mesh gradings can be designed for the numerical solution of this equation.
Statistical Evaluation of the Rodin–Ohno Hypothesis: Sense/Antisense Coding of Ancestral Class I and II Aminoacyl-tRNA Synthetases
Creators: name: Yardimci, Galip Gürkan
name: Carter, Charles W.
name: Erdogan, Ozgün
name: Roach, Jeffrey
name: Chandrasekaran, Srinivas Niranj
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: We tested the idea that ancestral class I and II aminoacyl-tRNA synthetases arose on opposite strands of the same gene. We assembled excerpted 94-residue Urgenes for class I tryptophanyl-tRNA synthetase (TrpRS) and class II Histidyl-tRNA synthetase (HisRS) from a diverse group of species, by identifying and catenating three blocks coding for secondary structures that position the most highly conserved, active-site residues. The codon middle-base pairing frequency was 0.35 ± 0.0002 in all-by-all sense/antisense alignments for 211 TrpRS and 207 HisRS sequences, compared with frequencies between 0.22 ± 0.0009 and 0.27 ± 0.0005 for eight different representations of the null hypothesis. Clustering algorithms demonstrate further that profiles of middle-base pairing in the synthetase antisense alignments are correlated along the sequences from one species-pair to another, whereas this is not the case for similar operations on sets representing the null hypothesis. Most probable reconstructed sequences for ancestral nodes of maximum likelihood trees show that middle-base pairing frequency increases to approximately 0.42 ± 0.002 as bacterial trees approach their roots; ancestral nodes from trees including archaeal sequences show a less pronounced increase. Thus, contemporary and reconstructed sequences all validate important bioinformatic predictions based on descent from opposite strands of the same ancestral gene. They further provide novel evidence for the hypothesis that bacteria lie closer than archaea to the origin of translation. Moreover, the inverse polarity of genetic coding, together with a priori α-helix propensities suggest that in-frame coding on opposite strands leads to similar secondary structures with opposite polarity, as observed in TrpRS and HisRS crystal structures.
Evidence for the Operation of the Hanle and Magneto-Optical Effects in the Scattering Polarization Signals Observed by CLASP2 Across the Mg II h and k Lines
Creators: name: Ishikawa, Ryohko
name: Bueno, Javier Trujillo
name: Ballester, Ernest Alsina
name: Belluzzi, Luca
name: Alemán, Tanausú del Pino
name: McKenzie, David E.
name: Auchère, Frédéric
name: Kobayashi, Ken
name: Okamoto, Takenori J.
name: Rachmeler, Laurel A.
name: Song, Donguk
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Radiative transfer investigations of the solar Mg II h and k resonance lines around 280~nm showed that, while their circular polarization (Stokes V) signals arise from the Zeeman effect, the linear polarization profiles (Stokes Q and U) are dominated by the scattering of anisotropic radiation and the Hanle and magneto-optical (MO) effects. Using the unprecedented observations of the Mg II and Mn I resonance lines obtained by the Chromospheric LAyer Spectro-Polarimeter (CLASP2), here we investigate how the linear polarization signals at different wavelengths (i.e., at the center, and at the near and far wings of the k line) vary with the longitudinal component of the magnetic field ($B_{L}$) at their approximate height of formation. The $B_{L}$ is estimated from the V signals in the aforementioned spectral lines. Particular attention is given to the following quantities that are expected to be influenced by the presence of magnetic fields through the Hanle and MO effects: the sign of the U signals, the total linear polarization amplitude ($LP$) and its direction ($χ$) with respect to a reference direction. We find that at the center and near wings of the $k$ line, the behavior of these quantities is significantly different in the observed quiet and plage regions, and that both $LP$ and $χ$ seem to depend on $B_{L}$. These observational results are indicative of the operation of the Hanle effect
description: 26 pages, 18 figures, accepted for publication in the Astrophysical Journal
Biofilms on submerged River Red Gum (Eucalyptus camaldulensis Dehnh. Myrtaceae) wood in billabongs: an analysis of bacterial assemblages using phospholipid profiles
Creators: name: Scholz, Oliver
name: Boon, Paul I
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

Biofilms were allowed to develop on wooden slides of the River Red Gum (Eucalyptus camaldulensis Dehnh., Myrtaceae) submerged in two billabongs of south-eastern Australia. The slides were placed in the photic zone and the aphotic zone, and the biofilms sampled after eight week''s growth over the summer of 1989–1990 and winter of 1990. Bacterial numbers, estimated with epifluorescence microscopy, ranged from 4–78 × 106 cells cm–2. Bacteria were more abundant in the photic zone than the aphotic zone, and more abundant in summer than winter. Fewer than 0.5% of the bacteria could be cultivated on nutrient agar plates. Concentrations of phospholipids ranged from 8–79 ng cm–2, which corresponded to bacterial abundances of 2–17 × 106 cells cm–2. Fifty five phospholipid fatty acids (PLFA) were identified, of which 16:0 (13–29% of total PFLA) was the most common. Other abundant PFLA included 16:17c (6–28%), 18:26 (3–16%), 18:33 (4–12%), 18:19c (3–5%), 18:l7c (5–11%) and 18:0 (2–8%). Minor PLFA included 14:0, i and a 15:0, 15:0, 16:l5c, 16:113c, 18:36, 18:43, 20:46 and 20:53. The PLFA profiles of the biofilms were quite different from those of the sediments and plankton. There was a clear distinction between the PLFA profiles of summer and winter biofilms, but less evidence for unequivocal site or light-regime effects.
Symblicit algorithms for optimal strategy synthesis in monotonic Markov decision processes
Creators: name: Bohy, Aaron
name: Bruyère, Véronique
name: Raskin, Jean-François
Publisher: name: arXiv
Year: 2014
Subjects: subject: Logic in Computer Science (cs.LO)
subject: Data Structures and Algorithms (cs.DS)
subject: Systems and Control (eess.SY)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: When treating Markov decision processes (MDPs) with large state spaces, using explicit representations quickly becomes unfeasible. Lately, Wimmer et al. have proposed a so-called symblicit algorithm for the synthesis of optimal strategies in MDPs, in the quantitative setting of expected mean-payoff. This algorithm, based on the strategy iteration algorithm of Howard and Veinott, efficiently combines symbolic and explicit data structures, and uses binary decision diagrams as symbolic representation. The aim of this paper is to show that the new data structure of pseudo-antichains (an extension of antichains) provides another interesting alternative, especially for the class of monotonic MDPs. We design efficient pseudo-antichain based symblicit algorithms (with open source implementations) for two quantitative settings: the expected mean-payoff and the stochastic shortest path. For two practical applications coming from automated planning and LTL synthesis, we report promising experimental results w.r.t. both the run time and the memory consumption.
description: In Proceedings SYNT 2014, arXiv:1407.4937
Additional file 1 of Employing cognitive interviewing to evaluate, improve and validate items for measuring the health-related quality of life of women diagnosed with ovarian cancer
Creators: name: Boban, Sharolin Ann
name: Bulsara, Caroline
name: Codde, Jim
name: Cohen, Paul A.
name: Downs, Jenny
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Published work of preceding research. Prior to this study, a qualitative study with women with OC was conducted, which identified key experiences and priorities such as challenges related to diagnosis and treatment, adjustments in their relationships with family and/or friends, and comments on useful coping strategies. These findings were expanded into a set of items that could be useful in developing a values-based OC PROM.
Brief an Henry
Creators: name: Auber, Daniel-François-Esprit
Publisher: name: [s.n.]
Year: 1820

description: von [Daniel François Esprit] Auber
description: Adressat kann nicht identifiziert werden.
description: Beiliegend Fotokopie des Auszugs aus dem Protokoll der Gemeinderats-Kommission der Stadt Olten vom 11.10.1950 betreffend den Kauf der Autographensammlung durch die Stadt Olten und Notizen von Cäsar von Arx.
description: Französisch
description: Den Brief erhielt Cäsar von Arx gemäss seinen Notizen im März 1938 von Carl Geigy-Hagenbach geschenkt.
description: Verzeichnung=Description=Inventaire November 2016 Neuaufnahme HBr
Statistical approach to inverse boundary problems for partial differential equations
Creators: name: Golubev, Georgi
name: Khasminskii, Rafail
Publisher: name: Weierstrass Institute
Year: 1997
Subjects: subject: Partial differential equation
subject: minimax estimator
subject: boundary problem
subject: 62G05

description: Inverse problems for elliptic and parabolic partial differential equations are considered. It is assumed that a solution of the equation is observed in white Gaussian noise with a small spectral density. The goal is to recover smooth but unknown boundary or initial conditions based on the noisy data. It is shown that the second order minimax estimators are linear as the spectral density of the noise goes to zero.
Brief an [Carlo] Pepoli
Creators: name: Bellini, Vincenzo
Publisher: name: [s.n.]
Year: 1834

description: von [Vincenzo] Bellini
description: Mit rotem Lacksiegel.
description: Italienisch
description: Den Brief erhielt Cäsar von Arx gemäss seinen beiliegenden Notizen am 11. März 1938 von Carl Geigy-Hagenbach geschenkt.
description: Verzeichnung=Description=Inventaire November 2016 Neuaufnahme HBr
Additional file 2 of Employing cognitive interviewing to evaluate, improve and validate items for measuring the health-related quality of life of women diagnosed with ovarian cancer
Creators: name: Boban, Sharolin Ann
name: Bulsara, Caroline
name: Codde, Jim
name: Cohen, Paul A.
name: Downs, Jenny
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2: Cognitive Interviewing Questionnaire. The questionnaire was created specifically for this study. CI using the CTA procedure was used to test identified statements from our previous qualitative study. Set of draft items was administered via telephone, Zoom and WhatsApp app on fourteen women with OC.
The history of reading is the history of each reader: a Public History of Education project [poster]
The history of reading is the history of each reader: a Public History of Education project [poster]
Creators: name: Dati, Monica
Publisher: name: M. Dati, "The history of reading is the history of each reader: a Public History of Education project", in Book of Abstract AIPH 2022, Quarta Conferenza Nazionale di Public History, Storia bene comune, Università Ca’ Foscari Venezia, M9 – Museo del ’900. Venezia-Mestre, 27-31 maggio 2022.
Year: 2025

description: The aim of this research is to investigate Public History and its relationship with the History of reading using digital resources, social memory and libraries. A new partnership to enhance the past and to promote the importance of reading through two projects: Madeleine in biblioteca and Un libro insieme.
Brief an [...]
Creators: name: Bizet, Georges
Publisher: name: [s.n.]
Year: 1860

description: von Georges Bizet
description: Französisch
description: Den Brief erhielt Cäsar von Arx gemäss seinen beiliegenden Notizen im März 1938 von Carl Geigy-Hagenbach geschenkt.
description: Verzeichnung=Description=Inventaire November 2016 Neuaufnahme HBr
Brief an L[...]
Creators: name: Saint-Saëns, Camille
Publisher: name: [s.n.]
Year: 1835

description: von C. Saint S[aëns]
description: Französisch
description: Den Brief erhielt Cäsar von Arx gemäss seinen beiliegenden Notizen von Carl Geigy-Hagenbach geschenkt.
description: Verzeichnung=Description=Inventaire November 2016 Neuaufnahme HBr
Laws, Causation and Dynamics at Different Levels
Creators: name: Butterfield, Jeremy
Publisher: name: arXiv
Year: 2014
Subjects: subject: History and Philosophy of Physics (physics.hist-ph)
subject: Popular Physics (physics.pop-ph)
subject: FOS: Physical sciences

description: I have two main aims. The first is general, and more philosophical (Section 2). The second is specific, and more closely related to physics (Sections 3 and 4). The first aim is to state my general views about laws and causation at different 'levels'. The main task is to understand how the higher levels sustain notions of law and causation that 'ride free' of reductions to the lower level or levels. I endeavour to relate my views to those of other symposiasts. The second aim is to give a framework for describing dynamics at different levels, emphasising how the various levels' dynamics can mesh or fail to mesh. This framework is essentially that of elementary dynamical systems theory. The main idea will be, for simplicity, to work with just two levels, dubbed 'micro' and 'macro' which are related by coarse-graining. I use this framework to describe, in part, the first four of Ellis' five types of top-down causation.
description: 29 pages, 3 figures
The SPIRou Legacy Survey Rotation period of quiet M dwarfs from circular polarization in near-infrared spectral lines: I. The SPIRou APERO analysis
Creators: name: Fouqué, P.
name: Martioli, E.
name: Donati, J. -F.
name: Lehmann, L. T.
name: Zaire, B.
name: Bellotti, S.
name: Gaidos, E.
name: Morin, J.
name: Moutou, C.
name: Petit, P.
name: Alencar, S. H. P.
name: Arnold, L.
name: Artigau, É.
name: Cang, T. -Q.
name: Carmona, A.
name: Cook, N. J.
name: Cortés-Zuleta, P.
name: Cristofari, P. I.
name: Delfosse, X.
name: Doyon, R.
name: Hébrard, G.
name: Malo, L.
name: Reylé, C.
name: Usher, C.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Context. The rotation period of stars is an important parameter along with mass, radius, effective temperature. It is an essential parameter for any radial velocity monitoring, as stellar activity can mimic the presence of a planet at the stellar rotation period. Several methods exist to measure it, including long sequences of photometric measurements or temporal series of stellar activity indicators. Aims. Here, we use the circular polarization in near-infrared spectral lines for a sample of 43 quiet M dwarfs and compare the measured rotation periods to those obtained with other methods. Methods. From Stokes V spectropolarimetric sequences observed with SPIRou at CFHT and the data processed with the APERO pipeline, we compute the least squares deconvolution profiles using different masks of atomic stellar lines with known Landé factor appropriate to the effective temperature of the star. We derive the longitudinal magnetic field to examine its possible variation along the 50 to 200 observations of each star. For determining the stellar rotation period, we apply a Gaussian process regression enabling us to determine the rotation period of stars with evolving longitudinal field. Results. Among the 43 stars of our sample, we were able to measure a rotation period for 27 stars. For 8 stars, the rotation period was previously unknown. We find a good agreement of our rotation periods with periods found in the literature based on photometry and activity indicators and confirm that near-infrared spectropolarimetry is an important tool to measure rotation periods, even for magnetically quiet stars. Furthermore, we compute ages for 20 stars of our sample using gyrochronology.
Adaptive Evolution of Signaling Partners
Creators: name: Bennetzen, Jeffrey L.
name: Dong, Taoran
name: Jones, Alan M.
name: Urano, Daisuke
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Proteins that interact coevolve their structures. When mutation disrupts the interaction, compensation by the partner occurs to restore interaction otherwise counterselection occurs. We show in this study how a destabilizing mutation in one protein is compensated by a stabilizing mutation in its protein partner and their coevolving path. The pathway in this case and likely a general principle of coevolution is that the compensatory change must tolerate both the original and derived structures with equivalence in function and activity. Evolution of the structure of signaling elements in a network is constrained by specific protein pair interactions, by requisite conformational changes, and by catalytic activity. The heterotrimeric G protein-coupled signaling is a paragon of this protein interaction/function complexity and our deep understanding of this pathway in diverse organisms lends itself to evolutionary study. Regulators of G protein Signaling (RGS) proteins accelerate the intrinsic GTP hydrolysis rate of the Gα subunit of the heterotrimeric G protein complex. An important RGS-contact site is a hydroxyl-bearing residue on the switch I region of Gα subunits in animals and most plants, such as Arabidopsis. The exception is the grasses (e.g., rice, maize, sugarcane, millets); these plants have Gα subunits that replaced the critical hydroxyl-bearing threonine with a destabilizing asparagine shown to disrupt interaction between Arabidopsis RGS protein (AtRGS1) and the grass Gα subunit. With one known exception (Setaria italica), grasses do not encode RGS genes. One parsimonious deduction is that the RGS gene was lost in the ancestor to the grasses and then recently acquired horizontally in the lineage S. italica from a nongrass monocot. Like all investigated grasses, S. italica has the Gα subunit with the destabilizing asparagine residue in the protein interface but, unlike other known grass genomes, still encodes an expressed RGS gene, SiRGS1. SiRGS1 accelerates GTP hydrolysis at similar concentration of both Gα subunits containing either the stabilizing (AtGPA1) or destabilizing (RGA1) interface residue. SiRGS1 does not use the hydroxyl-bearing residue on Gα to promote GAP activity and has a larger Gα-interface pocket fitting to the destabilizing Gα. These findings indicate that SiRGS1 adapted to a deleterious mutation on Gα using existing polymorphism in the RGS protein population.
title: Developing policy evaluation in an academic setting: assets and challenges (Débats du LIEPP, n°7)
Creators: name: Revillard, Anne
name: Corno, Lucia
name: Fernandez, Jose-Luis
name: Fernandez, Jose-Luis
name: Mason, Danielle
name: Umbach, Gaby
name: Bodenstein, Thilo
name: Cartwright, Andrew
name: Melenciuc, Ioana-Roxana
name: Wegrich, Kai
name: Stone, Diane
Publisher: name: Sciences Po - LIEPP
Year: 2023
Subjects: subject: FOS: Social sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Based on a seminar organized by LIEPP and CIVICA which took place at Sciences Po in June 2022, this publication brings together ten academic researchers from seven different CIVICA universities (Bocconi, CEU, EUI, Hertie School, LSE, Sciences Po, SNSPA), who are involved in various forms of policy evaluation. These contributions from Austria, France, Germany, Hungary, Italy, Romania, and the United Kingdom, reflect on the assets and challenges of developing policy evaluation in an academic setting. The seminar was organized as part of CIVICA’s research focus on “Democracy in the 21st century”, but through the crosscutting nature of program evaluation, it is also of interest to CIVICA’s three others research streams (on societies in transition, data, and Europe revisited). The aim of this debate is thus to better understand the specificities, assets and challenges of developing evaluation from within an academic setting, in view of eventually reflecting on possible ways to collectively reinforce this practice within CIVICA, and use CIVICA as a leverage to reinforce this practice. This debate is organized around two topics, developing academic evaluative research, and the role of academic institutions in outreach and training in evaluation. Contributions are based on presentations of the experiences of each CIVICA partner.
Relations between entropy rate, entropy production and information geometry in linear stochastic systems
Creators: name: Guel-Cortez, Adrian-Josue
name: Kim, Eun-jin
Publisher: name: arXiv
Year: 2023
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: In this work, we investigate the relation between the concept of ``information rate'', an information geometric method for measuring the speed of the time evolution of the statistical states of a stochastic process, and stochastic thermodynamics quantities like entropy rate and entropy production. Then, we propose the application of entropy rate and entropy production to different practical applications such as abrupt event detection, correlation analysis, and control engineering. Specifically, by utilising the Fokker-Planck equation of multi-variable linear stochastic processes described by Langevin equations, we calculate the exact value for information rate, entropy rate, and entropy production and derive various inequalities among them. Inspired by classical correlation coefficients and control techniques, we create entropic-informed correlation coefficients as abrupt event detection methods and information geometric cost functions as optimal thermodynamic control policies, respectively. The methods are analysed via the numerical simulations of common prototypical systems.
description: 32 pages
Drosophila Apc2 Is a Cytoskeletally-Associated Protein That Regulates Wingless Signaling in the Embryonic Epidermis
Creators: name: Kirkpatrick, Catherine
name: Moline, Melissa M.
name: Baas, Annette
name: Dierick, Herman A.
name: Peifer, Mark
name: Bejsovec, Amy
name: McCartney, Brooke M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: The tumor suppressor adenomatous polyposis coli (APC) negatively regulates Wingless (Wg)/Wnt signal transduction by helping target the Wnt effector β-catenin or its Drosophila homologue Armadillo (Arm) for destruction. In cultured mammalian cells, APC localizes to the cell cortex near the ends of microtubules. Drosophila APC (dAPC) negatively regulates Arm signaling, but only in a limited set of tissues. We describe a second fly APC, dAPC2, which binds Arm and is expressed in a broad spectrum of tissues. dAPC2's subcellular localization revealed colocalization with actin in many but not all cellular contexts, and also suggested a possible interaction with astral microtubules. For example, dAPC2 has a striking asymmetric distribution in neuroblasts, and dAPC2 colocalizes with assembling actin filaments at the base of developing larval denticles. We identified a dAPC2 mutation, revealing that dAPC2 is a negative regulator of Wg signaling in the embryonic epidermis. This allele acts genetically downstream of wg, and upstream of arm, dTCF, and, surprisingly, dishevelled. We discuss the implications of our results for Wg signaling, and suggest a role for dAPC2 as a mediator of Wg effects on the cytoskeleton. We also speculate on more general roles that APCs may play in cytoskeletal dynamics.