cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Unprovoked venous thromboembolism in women: Is screening with mammography and abdominopelvic CT of benefit?
Creators: name: Daley, Flora
Publisher: name: European Congress of Radiology
Year: 2020
Subjects: subject: Oncologic Imaging
subject: Breast
subject: Oncology
subject: Vascular
subject: CT
subject: Screening
subject: Embolism / Thrombosis
subject: Prospective
subject: Observational
subject: Performed at one institution

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Numerous studies have reviewed the incidence of malignancy after an episode of unproved venous thromboembolism and found it to be in the region of 4% 1,2 . As expected, the common cancers detected in this cohort mirror that of the general population...
Replicating Cardiovascular Condition-Birth Month Associations
Creators: name: Li, Li
name: Boland, Mary Regina
name: Miotto, Riccardo
name: Tatonetti, Nicholas P.
name: Dudley, Joel T.
Publisher: name: Columbia University
Year: 2016
Subjects: Cardiovascular system--Diseases--Risk factors
Epidemiology
Medical informatics
Environmental health

description: Independent replication is vital for study findings drawn from Electronic Health Records (EHR). This replication study evaluates the relationship between seasonal effects at birth and lifetime cardiovascular condition risk. We performed a Season-wide Association Study on 1,169,599 patients from Mount Sinai Hospital (MSH) to compute phenome-wide associations between birth month and CVD. We then evaluated if seasonal patterns found at MSH matched those reported at Columbia University Medical Center. Coronary arteriosclerosis, essential hypertension, angina, and pre-infarction syndrome passed phenome-wide significance and their seasonal patterns matched those previously reported. Atrial fibrillation, cardiomyopathy, and chronic myocardial ischemia had consistent patterns but were not phenome-wide significant. We confirm that CVD risk peaks for those born in the late winter/early spring among the evaluated patient populations. The replication findings bolster evidence for a seasonal birth month effect in CVD. Further study is required to identify the environmental and developmental mechanisms.
Performansi Implementasi Paralel OpenMP pada Persamaan Air Dangkal 2D untuk Simulasi Gelombang Runup
Creators: name: Adytia, Didit
name: Jeriano, Novalianda
Publisher: name: Indonesia Journal on Computing (Indo-JC)
Year: 2020

description: Terdapat banyak aliran dangkal di alam seperti tsunami, aliran banjir, aliran pada sungai, pasang surut air laut, dan sebagainya. Aliran dangkal dapat disimulasikan dengan menggunakan Persamaan Air Dangkal atau Shallow Water Equations (SWE). Salah satu fenomena nonlinear yang penting dalam aliran dangkal adalah fenomena runup. Khususnya untuk menyimulasikan fenomena runup secara akurat, perlakuan khusus pada implementasi numerik dari model gelombang harus dilakukan. Pada artikel ini, persamaan SWE diimplementasikan dengan metode Finite Volume pada grid komputasi dengan model momentum conservative staggered grid. Untuk meningkatkan performasi komputasi terutama untuk menyimulasikan domain komputasi yang besar dengan resolusi grid tinggi, pada paper ini skema numerik tersebut diimplementasikan dengan metode arsitektur OpenMP. Performansi algoritma paralel dikuantifikasi dengan menghitung speedup dan efisiensi. Dari hasil paralelisasi tersebut, didapatkan efisiensi pada waktu komputasi untuk kasus-kasus dengan jumlah grid komputasi yang besar.
description: Indonesia Journal on Computing (Indo-JC), Vol. 5 No. 1 (2020): Maret, 2020
Pair diffusion, hydrodynamic interactions, and available volume in dense fluids
Creators: name: Mittal, Jeetain
name: Hummer, Gerhard
Publisher: name: arXiv
Year: 2012
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We calculate the pair diffusion coefficient D(r) as a function of the distance r between two hard-sphere particles in a dense monodisperse suspension. The distance-dependent pair diffusion coefficient describes the hydrodynamic interactions between particles in a fluid that are central to theories of polymer and colloid dynamics. We determine D(r) from the propagators (Green's functions) of particle pairs obtained from discontinuous molecular dynamics simulations. At distances exceeding 3 molecular diameters, the calculated pair diffusion coefficients are in excellent agreement with predictions from exact macroscopic hydrodynamic theory for large Brownian particles suspended in a solvent bath, as well as the Oseen approximation. However, the asymptotic 1/r distance dependence of D(r) associated with hydrodynamic effects emerges only after the pair distance dynamics has been followed for relatively long times, indicating non-negligible memory effects in the pair diffusion at short times. Deviations of the calculated D(r) from the hydrodynamic models at short distances r reflect the underlying many-body fluid structure, and are found to be correlated to differences in the local available volume. The procedure used here to determine the pair diffusion coefficients can also be used for single-particle diffusion in confinement with spherical symmetry.
description: 6 pages, 5 figures
Time-dependent reversal of synaptic plasticity induced by physiological concentrations of oligomeric Aβ42: an early index of Alzheimer’s disease
Creators: name: Koppensteiner, Peter
name: Trinchese, Fabrizio
name: Fa, Mauro
name: Puzzo, Daniela
name: Gulisano, Walter
name: Yan, Shijun
name: Poussin, Arthur
name: Liu, Shumin
name: Orozco, Ian Jay
name: Dale, Elena
name: Teich, Andrew Franklin
name: Palmeri, Agostino
name: Ninan, Ipe
name: Boehm, Stefan
name: Arancio, Ottavio
Publisher: name: Columbia University
Year: 2016
Subjects: Alzheimer's disease--Forecasting
Nervous system--Degeneration
Neurophysiology
Neuroplasticity

description: The oligomeric amyloid-β (Aβ) peptide is thought to contribute to the subtle amnesic changes in Alzheimer’s disease (AD) by causing synaptic dysfunction. Here, we examined the time course of synaptic changes in mouse hippocampal neurons following exposure to Aβ42 at picomolar concentrations, mimicking its physiological levels in the brain. We found opposite effects of the peptide with short exposures in the range of minutes enhancing synaptic plasticity, and longer exposures lasting several hours reducing it. The plasticity reduction was concomitant with an increase in the basal frequency of spontaneous neurotransmitter release, a higher basal number of functional presynaptic release sites, and a redistribution of synaptic proteins including the vesicle-associated proteins synapsin I, synaptophysin, and the post-synaptic glutamate receptor I. These synaptic alterations were mediated by cytoskeletal changes involving actin polymerization and p38 mitogen-activated protein kinase. These in vitro findings were confirmed in vivo with short hippocampal infusions of picomolar Aβ enhancing contextual memory and prolonged infusions impairing it. Our findings provide a model for initiation of synaptic dysfunction whereby exposure to physiologic levels of Aβ for a prolonged period of time causes microstructural changes at the synapse which result in increased transmitter release, failure of synaptic plasticity, and memory loss.
title: Combined Texture Analysis of Diffusion-Weighted Imaging with Conventional MR Imaging for Noninvasive Assessment of IDH1 Mutation in Anaplastic Gliomas
Creators: name: Su, Chun
Publisher: name: European Congress of Radiology
Year: 2020
Subjects: subject: Performed at one institution
subject: Not applicable
subject: Retrospective
subject: Genetic defects
subject: Surgery
subject: MR-Diffusion/Perfusion
subject: Neuroradiology brain
subject: Neuro

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Anaplastic gliomas (AGs), classified as World Health Organization(WHO) grade III, are aggressive brain tumors. The clinical characteristics, radiologic features and genetic changes all play important roles in determining the prognosis of patients...
China’s South Asia policy through a domestic sovereignty perspective
Creators: name: Indraguptha, Gihan Dhanushka
Publisher: name: University of British Columbia
Year: 2011

description: China’s South Asia Policy is currently perceived mostly from realist geopolitical and to a lesser degree, commercial liberalism perspectives. These frameworks ignore China’s own vulnerabilities in its restive periphery which are significant factors in determining policy towards its neighbours. This is especially true in South Asia since Xinjiang and Tibet, the two most volatile minority areas, border this region. The ‘core-periphery structure’ offers a useful tool to fathom China’s contradictory dichotomy where it exists as a strong state at its ‘core’ while being insecure and weak in the ‘periphery’. This dichotomy is seen in dealings with its neighbours as well. As a result, the realist geopolitical analysis offers a sufficient framework to understand China’s interactions with nations bordering its ‘core’, for example in Southeast and Northeast Asia, where it projects itself as a strong, unified state. Yet such an analysis will fall short when explaining the PRC’s interactions with states neighbouring its periphery, in this case in South Asia, due to a perceived ‘insecurity dilemma’. An economics-driven commercial liberalism perspective would also fail to capture the internal complexities and perceived vulnerabilities faced by the PRC in its interaction with South Asia. Therefore it is useful to explore an alternative framework taking account of domestic sovereignty factors. The perceived ‘insecurity dilemma’ in the periphery have been addressed by the PRC since 1949 through policies that sought to assimilate these regions with the ‘core’ of the country. Initially these policies attempted assimilation through coercion but since the late 1970s, a softer approach has been applied through economic empowerment and reduction of disparities. An extension of these domestic policies in Xinxiang and Tibet are reflected in the PRC’s dealings with nations that border these regions. With regard to South Asia, a closer scrutiny reveals such interconnections in the PRC’s policies towards Afghanistan and Pakistan with relation to Xinjiang and similarly towards India, Nepal and Bhutan with relation to Tibet. Such an assessment that takes note of domestic sovereignty considerations offers a more comprehensive analysis of China’s South Asia policy and would contribute to alleviate tensions resulting from misinterpretation of these policies.
LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts
Creators: name: Kuwahara, Tomoki
name: Inoue, Keiichi
name: D’Agati, Vivette D.
name: Fujimoto, Tetta
name: Eguchi, Tomoya
name: Saha, Shamol
name: Wolozin, Benjamin
name: Iwatsubo, Takeshi
name: Abeliovich, Asa
Publisher: name: Columbia University
Year: 2016
Subjects: Lysosomes
Nervous system--Diseases
Pathology

description: Leucine-rich repeat kinase 2 (LRRK2) has been linked to several clinical disorders including Parkinson’s disease (PD), Crohn’s disease, and leprosy. Furthermore in rodents, LRRK2 deficiency or inhibition leads to lysosomal pathology in kidney and lung. Here we provide evidence that LRRK2 functions together with a second PD-associated gene, RAB7L1, within an evolutionarily conserved genetic module in diverse cellular contexts. In C. elegans neurons, orthologues of LRRK2 and RAB7L1 act coordinately in an ordered genetic pathway to regulate axonal elongation. Further genetic studies implicated the AP-3 complex, which is a known regulator of axonal morphology as well as of intracellular protein trafficking to the lysosome compartment, as a physiological downstream effector of LRRK2 and RAB7L1. Additional cell-based studies implicated LRRK2 in the AP-3 complex-related intracellular trafficking of lysosomal membrane proteins. In mice, deficiency of either RAB7L1 or LRRK2 leads to prominent age-associated lysosomal defects in kidney proximal tubule cells, in the absence of frank CNS pathology. We hypothesize that defects in this evolutionarily conserved genetic pathway underlie the diverse pathologies associated with LRRK2 in humans and in animal models.
Polish Rod Displacement Simulation on Sucker Rod Pump Using the Piecewise-Linear Basis Method
Creators: name: Nurseta Wijaya, I Gde Made Bagus
name: Aditsania, Annisa
name: Gunawan, Putu Harry
Publisher: name: Indonesia Journal on Computing (Indo-JC)
Year: 2020

description: Sucker Rod Pump (SRP) is a heavy equipment used to pump oil(ﬂuid) from the ground. The purpose of this study is to determine the numerical solution of displacement problems on the polish rod in the sucker rod pump. From previous studies displacement can be simulated and calculated numerical solutions using the Finite Difference method. But in this study the method that will be used is the Piecewise-Linear Base method to simulate displacement on the polish rod and compared to the analytic simulation of the problem. From the simulation results both methods obtained an error rate 2.00911 x 10−17 at ∆x = 0.2, 3.30195 x 10−17 at ∆x = 0.05 and 1.45114 x 10−16 at ∆x = 0.02.
description: Indonesia Journal on Computing (Indo-JC), Vol. 5 No. 1 (2020): Maret, 2020
On Graph Refutation for Relational Inclusions
Creators: name: Veloso, Paulo A. S.
name: Veloso, Sheila R. M.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences

description: We introduce a graphical refutation calculus for relational inclusions: it reduces establishing a relational inclusion to establishing that a graph constructed from it has empty extension. This sound and complete calculus is conceptually simpler and easier to use than the usual ones.
description: In Proceedings LSFA 2011, arXiv:1203.5423
title: The use of multi-parameter analysis of the magnetic resonance diffusion signal in the diagnosis of pancreatic malignant neoplasms.
Creators: name: Nadolska, Katarzyna
Publisher: name: European Congress of Radiology
Year: 2020
Subjects: subject: Oncologic Imaging
subject: Oncology
subject: Pancreas
subject: MR-Diffusion/Perfusion
subject: Diagnostic procedure
subject: Imaging sequences
subject: Cancer
subject: Image verification
subject: Retrospective
subject: Cross-sectional study
subject: Performed at one institution

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Tumors of the pancreas are a significant population problem. Pancreatic cancer is one of the most recently detected malignant cancers. In Poland, most cases are diagnosed in stage IV. About 80-85% of patients at the time of diagnosis of the disease...
Donor CD47 controls T cell alloresponses and is required for tolerance induction following hepatocyte allotransplantation
Creators: name: Zhang, Mingyou
name: Wang, Hui
name: Tan, Shulian
name: Navarro-Alvarez, Nalu
name: Zheng, Yang
name: Yang, Yong-Guang
Publisher: name: Columbia University
Year: 2016
Subjects: T cells
Biocompatibility
Liver cells
Biochemistry

description: CD47-deficient hepatocyte transplantation induces rapid innate immune cell activation and subsequent associated graft loss in syngeneic recipients. However, the role of donor CD47 in regulation of T-cell alloresponses is poorly understood. We addressed this question by assessing OVA-specific immune responses in mice following hepatocyte transplantation from CD47-competent or -deficient OVAtransgenic donors. Compared to sham-operated controls, intrasplenic transplantation of CD47-deficient OVA+ hepatocytes significantly accelerated rejection of OVA+ skin grafted 7 days after hepatocyte transplantation. In contrast, mice receiving CD47-competent OVA+ hepatocytes showed prolonged and even indefinite survival of OVA+ skin allografts. T cells from mice receiving CD47-deficient, but not CD47-competent, OVA+ hepatocytes showed significantly enhanced responses to OVA+ stimulators compared to sham-operated controls. In contrast to the production of tolerogenic cytokines (IL-4 and IL-10) in the recipients of CD47-competent hepatocytes, mice receiving CD47-deficient hepatocytes showed elevated production of IFN-γ and IL-1α. Moreover, significant expansion of myeloid-derived suppressor cells was detected in the recipients of CD47-competent hepatocytes, which was required for tolerance induction in these mice. Thus, donor CD47 plays an important role in the control of T-cell alloresponses and tolerance induction following hepatocyte transplantation. Our data also suggest that intrasplenic hepatocyte transplantation may provide a means to induce allograft tolerance.
Determining N-Days Tourist Route Using Swap Operator Based Artificial Bee Colony Algorithm
Creators: name: Istiqamah, Ayunda Farah
name: Baizal, Z K Abdurahman
name: Murti, Yusza Reditya
Publisher: name: Indonesia Journal on Computing (Indo-JC)
Year: 2020

description: Traveling is one of the activities chosen by many people to spend holidays. Some tourists want to go on vacation in a place they have never visited before, so they need a tool to plan a tour. Planning this tour includes determining tourist route. We analogize the determination of tourist routes using Traveling Salesman Problem (TSP). The main objective of this study was to find the optimal tourist route using Swap Operator Based Artificial Bee Colony Algorithm. We use Multi-Attribute Utility Theory (MAUT) to accommodate user needs for the route that recommended by the system. The criteria for user preferences used in this study are: 1) routes with as many tourist attractions as possible, 2) routes that pass popular destinations, and 3) routes with minimal costs. Based on the experiment results, Swap Operator Based Artificial Bee Colony gives more optimal results than the Simulated Annealing, especially in terms of the number of tourist attractions (nodes) that can be visited in one trip. Keywords: Multi-Attribute Utility Theory, Swap Operator Based Artificial Bee Colony Algorithm, Traveling Salesman Problem
description: Indonesia Journal on Computing (Indo-JC), Vol. 5 No. 1 (2020): Maret, 2020
Plasmonic mode converter for controlling optical impedance and nanoscale light-matter interaction
Creators: name: Hung, Yun-Ting
name: Huang, Chen-Bin
name: Huang, Jer-Shing
Publisher: name: arXiv
Year: 2012
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: To enable multiple functions of plasmonic nanocircuits, it is of key importance to control the propagation properties and the modal distribution of the guided optical modes such that their impedance matches to that of nearby quantum systems and desired light-matter interaction can be achieved. Here, we present efficient mode converters for manipulating guided modes on a plasmonic two-wire transmission line. The mode conversion is achieved through varying the path length, wire cross section and the surrounding index of refraction. Instead of pure optical interference, strong near-field coupling of surface plasmons results in great momentum splitting and modal profile variation. We theoretically demonstrate control over nanoantenna radiation and discuss the possibility to enhance nanoscale light-matter interaction. The proposed converter may find applications in surface plasmon amplification, index sensing and enhanced nanoscale spectroscopy.
description: 14 pages, 6 figures
Pengenalan Aksara Bali Menggunakan Metode Pyramid Histogram of Oriented Gradients
Creators: name: Sthevanie, Febryanti
name: Aristya, I Putu Indra
name: Ramadhani, Kurniawan Nur
Publisher: name: Indonesia Journal on Computing (Indo-JC)
Year: 2020

description: Aksara Bali terdiri dari 18 aksara dasar (biasa disebut aksara Wianjana) yang masing-masing terdiri atas 7 aksara vokal (pengangge suara). Penulisan aksara Bali dapat ditulis pada kertas ataupun daun tal yang sudah dikeringkan dan memiliki tekstur yang kasar serta mudah sobek sehingga membuat sulit dibaca. Maka dari itu, dibuat sistem yang dapat mengenali aksara Bali pada daun tal untuk membantu dapat membaca aksara Bali. Sistem ini dibangun menggunakan metode Pyramid Histogram of Oriented Gradient (PHOG) sebagai metode ekstraksi ciri. Dataset yang digunakan adalah dataset dari AMADI Lontar Set yang berupa gambar berjumlah 19.383 gambar dengan 133 kelas. Pada pengujian didapatkan nilai f1-score terbaik pada PHOG level 3 dengan 6 bin orientasi dan klasifikasi menggunakan SVM kernel linear yaitu sebesar 66.49% dan akurasi sebesar 81.35%.
description: Indonesia Journal on Computing (Indo-JC), Vol. 5 No. 1 (2020): Maret, 2020
title: 6DOF robotic patient positioning platform HexaPOD™: from installation to treatment execution​
Creators: name: Roletto, Andrea
Publisher: name: European Congress of Radiology
Year: 2020
Subjects: subject: Performed at one institution
subject: Not applicable
subject: Retrospective
subject: Radiotherapy techniques
subject: Image guided radiotherapy
subject: Cancer
subject: Radiation therapy / Oncology
subject: Cone beam CT
subject: Pelvis
subject: Oncology
subject: Patient Care
subject: Head and neck

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Among the parameters that a radiographer should consider fundamental to reduce errors and obtain the best possible precision during a radiotherapy treatment, we can find patient positioning and organ motion regarding the treated anatomical district....
Focused ultrasound-enhanced intranasal brain delivery of brain-derived neurotrophic factor
Creators: name: Chen, Hong
name: Zong Xin Yang, Georgiana
name: Getachew, Hoheteberhan
name: Acosta, Camilo
name: Sánchez, Carlos Jose Sierra
name: Konofagou, Elisa E.
Publisher: name: Columbia University
Year: 2016
Subjects: Diagnostic ultrasonic imaging
Brain
Neurotrophic functions
Biochemistry
Intranasal medication

description: The objective of this study was to unveil the potential mechanism of focused ultrasound (FUS)- enhanced intranasal (IN) brain drug delivery and assess its feasibility in the delivery of therapeutic molecules. Delivery outcomes of fluorescently-labeled dextrans to mouse brains by IN administration either before or after FUS sonication were compared to evaluate whether FUS enhances IN delivery by active pumping or passive diffusion. Fluorescence imaging of brain slices found that IN administration followed by FUS sonication achieved significantly higher delivery than IN administration only, while pre-treatment by FUS sonication followed by IN administration was not significantly different from IN administration only. Brain-derived neurotrophic factor (BDNF), a promising neurotrophic factor for the treatment of many central nervous system diseases, was delivered by IN followed by FUS to demonstrate the feasibility of this technique and compared with the established FUS technique where drugs are injected intravenously. Immunohistochemistry staining of BDNF revealed that FUS-enhanced IN delivery achieved similar locally enhanced delivery as the established FUS technique. This study suggested that FUS enhances IN brain drug delivery by FUS-induced active pumping of the drug and demonstrated that FUS-enhanced IN delivery is a promising technique for noninvasive and localized delivery of therapeutic molecules to the brain.
title: Improving the pulmonary embolism pathway: Can an increased D-Dimer threshold safely reduce the requirement for CT Pulmonary Angiography in low-risk patients?
Creators: name: Morgan, Leo
Publisher: name: European Congress of Radiology
Year: 2020
Subjects: subject: Chest
subject: Cardiovascular system
subject: Lung
subject: Pulmonary vessels
subject: CT
subject: CT-Angiography
subject: Audit and standards
subject: Blood
subject: Embolism / Thrombosis
subject: Retrospective
subject: Observational
subject: Performed at one institution

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Fast and accurate diagnosis of pulmonary embolism (PE) is crucial to patient care. Many centres rely upon established pathways to achieve this goal, using validated risk stratification, D-Dimer blood tests and CT Pulmonary Angiography (CTPA). In our...
title: Hydrology days 2001: conference program
title: AGU hydrology days 2001
titleType: AlternativeTitle
title: Conference program: Hydrology days
titleType: AlternativeTitle
Creators: name: American Geophysical Union, Author
name: Colorado State University, Author
name: Colorado State University, Publisher
Publisher: name: Mountain Scholar
Year: 2001
Subjects: subject: Hydrology -- Congresses

description: The 21st annual AGU hydrology days was held in the Cherokee Park Room, Lory Student Center, Colorado State University on April 2-5, 2001. To access abstracts, please see: http://hydrologydays.colostate.edu/schedule_01.htm.
Imaginary-Scaling versus Indefinite-Metric Quantization of the Pais-Uhlenbeck Oscillator
Creators: name: Mostafazadeh, Ali
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Using the Pais-Uhlenbeck Oscillator as a toy model, we outline a consistent alternative to the indefinite-metric quantization scheme that does not violate unitarity. We describe the basic mathematical structure of this method by giving an explicit construction of the Hilbert space of state vectors and the corresponding creation and annihilation operators. The latter satisfy the usual bosonic commutation relation and differ from those of the indefinite-metric theories by a sign in the definition of the creation operator. This change of sign achieves a definitization of the indefinite-metric that gives life to the ghost states without changing their contribution to the energy spectrum.
description: Published version, 7 pages
A novel, rapid method to compare the therapeutic windows of oral anticoagulants using the Hill coefficient
Creators: name: Chang, Jeremy B.
name: Quinnies, Kayla M.
name: Realubit, Ronald B.
name: Karan Jr., Charles
name: Rand, Jacob H.
name: Tatonetti, Nicholas P.
Publisher: name: Columbia University
Year: 2016
Subjects: Anticoagulants (Medicine)
Oral medicine
Pharmacokinetics
Medicine
Pharmacology

description: A central challenge in designing and administering effective anticoagulants is achieving the proper therapeutic window and dosage for each patient. The Hill coefficient, nH, which measures the steepness of a dose-response relationship, may be a useful gauge of this therapeutic window. We sought to measure the Hill coefficient of available anticoagulants to gain insight into their therapeutic windows. We used a simple fluorometric in vitro assay to determine clotting activity in platelet poor plasma after exposure to various concentrations of anticoagulants. The Hill coefficient for argatroban was the lowest, at 1.7±0.2 (95% confidence interval, CI), and the Hill coefficient for fondaparinux was the highest, at 4.5±1.3 (95% CI). Thus, doubling the dose of fondaparinux from its IC50 would decrease coagulation activity by nearly a half, whereas doubling the dose of argatroban from its IC50 would decrease coagulation activity by merely one quarter. These results show a significant variation among the Hill coefficients, suggesting a similar variation in therapeutic windows among anticoagulants in our assay.
title: Down syndrome: prevalence analysis of CNS pathologies in a cohort of brain MRI studies
Creators: name: BARRANCO ACOSTA, SARA
Publisher: name: European Congress of Radiology
Year: 2020
Subjects: subject: Performed at one institution
subject: Cross-sectional study
subject: Retrospective
subject: Dementia
subject: Screening
subject: MR
subject: CNS
subject: Neuro

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Down syndrome (DS) or trisomy 21, is the main genetic cause of intellectual disability worldwide, with an incidence of approximately 1/1000 live newborns, and and increasing risk with maternal age. Phenotypically they have very characteristic...
An implantable compound-releasing capsule triggered on demand by ultrasound
Creators: name: Ordeig, Olga
name: Chin, SauYin
name: Kim, Sohyun
name: Chitnis, Parag V.
name: Sia, Samuel K.
Publisher: name: Columbia University
Year: 2016
Subjects: Capsules (Pharmacy)
Implants, Artificial
Diagnostic ultrasonic imaging
Medicine

description: Implantable devices have a large potential to improve human health, but they are often made of biofouling materials that necessitate special coatings, rely on electrical connections for external communication, and require a continuous power source. This paper demonstrates an alternative platform, which we call iTAG (implantable thermally actuated gel), where an implanted capsule can be wirelessly controlled by ultrasound to trigger the release of compounds. We constructed a millimetersized capsule containing a co-polymer gel (NiPAAm-co-AAm) that contracts above body temperature (i.e. at 45°C) to release compounds through an opening. This gel-containing capsule is biocompatible and free of toxic electronic or battery components. An ultrasound hardware, with a focused ultrasound (FUS) transducer and a co-axial A-mode imaging transducer, was used to image the capsule (to monitor in real time its position, temperature, and effectiveness of dose delivery), as well as to trigger a rapid local rise in temperature, contraction of gel, and release of compounds in vitro and in vivo. The combination of this gel-based capsule and compact ultrasound hardware can serve as a platform for triggering local release of compounds, including potentially in deep tissue, to achieve tailored personalized therapy.
title: Evaluating the use of FDG-18 PET in a regional gynaecological MDT: A 3 year retrospective study
Creators: name: Munjal, Ishaana
Publisher: name: European Congress of Radiology
Year: 2020
Subjects: subject: Genitourinary
subject: Genital / Reproductive system female
subject: Nuclear medicine
subject: Pelvis
subject: PET-CT
subject: Staging
subject: Cancer
subject: Retrospective
subject: Not applicable
subject: Performed at one institution

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: FDG PET-CT is an integral part of staging and evaluating treatment response in gynaecological cancer, particularly cervical cancer. Clinical teams considering management and treatment options rely on accurate radiological staging; this takes the...
Deteksi Helm pada Video Pengendara Sepeda Motor menggunakan Ekstraksi Ciri Histogram of Oriented Gradients
Creators: name: Sthevanie, Febryanti
name: Kurniawan, Anang
name: Ramadhani, Kurniawan Nur
Publisher: name: Indonesia Journal on Computing (Indo-JC)
Year: 2020

description: World Health Organization mencatat sampai tahun 2015 kecelakaan di jalan telah merenggut 1.2 juta jiwa tiap tahunnya. Kecelakaan paling banyak dialami oleh pengendara sepeda motor karena minimnya keamanan yang melindungi pengendara sepeda motor, dan juga rendahnya kesadaran pengguna sepeda motor untuk menggunakan perangkat keselamatan yang sesuai dengan Undang-Undang. Riset-riset te- lah dilakukan diantaranya membuat sistem pendeteksi helm pada pengendara sepeda motor menggunakan metode ekstraksi fitur HOG, SIFT, LBP yang dapat menghasilkan performansi rata-rata masing masing, 93%, 64%, 64% dengan menggunakan metode klasifikasi SVM. Pada penelitian ini dibuat sebuah sistem yang dapat mendeteksi helm pada pengendara sepeda motor secara otomatis menggunak- an ekstraksi fitur Histogram of Oriented Gradient. Hasil tertinggi yang didapatkan dari hasil pengujian adalah fmeasure 90.67%, menggunakan metode ekstraksi fitur HOG dengan kondisi ukuran cell 8x8 pixels dan jumlah 9 bins dengan sudut 180o. Hasil tersebut dicapai menggunakan metode klasifikasi SVM dengan kernel polynomial derajat 3.
description: Indonesia Journal on Computing (Indo-JC), Vol. 5 No. 1 (2020): Maret, 2020
Controlling edge dynamics in complex networks
Creators: name: Nepusz, Tamás
name: Vicsek, Tamás
Publisher: name: arXiv
Year: 2011
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Social and Information Networks (cs.SI)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: The interaction of distinct units in physical, social, biological and technological systems naturally gives rise to complex network structures. Networks have constantly been in the focus of research for the last decade, with considerable advances in the description of their structural and dynamical properties. However, much less effort has been devoted to studying the controllability of the dynamics taking place on them. Here we introduce and evaluate a dynamical process defined on the edges of a network, and demonstrate that the controllability properties of this process significantly differ from simple nodal dynamics. Evaluation of real-world networks indicates that most of them are more controllable than their randomized counterparts. We also find that transcriptional regulatory networks are particularly easy to control. Analytic calculations show that networks with scale-free degree distributions have better controllability properties than uncorrelated networks, and positively correlated in- and out-degrees enhance the controllability of the proposed dynamics.
description: Preprint. 24 pages, 4 figures, 2 tables. Source code available at http://github.com/ntamas/netctrl
Deteksi Spoofing Wajah Manusia Berbasis Video menggunakan Metode Local Derivative Pattern-Three Orthogonal Planes
Creators: name: Sthevanie, Febryanti
name: Yuniasih, Diah Ajeng Dwi
name: Ramadhani, Kurniawan Nur
Publisher: name: Indonesia Journal on Computing (Indo-JC)
Year: 2020

description: Saat ini banyak sistem yang menggunakan pengenalan wajah sebagai keamanan. Namun, penggunaan wajah tersebut masih memiliki kerentanan terhadap serangan spoofing, yaitu serangan dengan cara memalsukan foto atau video dari pengguna asli sistem tersebut. Untuk menghindari adanya tindakan kriminal tersebut, diusulkan sebuah sistem yang dapat mendeteksi serangan spoofing menggunakan metode Local Derivative Pattern dari Three Orthogonal Planes. Dataset yang digunakan adalah bersumber dari empat dataset publik yang berbeda yaitu Idiap Replay-Attack Database, MSU MFSD Database, Casia FASD Database dan NUAA Imposter Database yang berformat video. Dari hasil pengujian, pada skenario intra-dataset didapatkan performansi terbaik dengan rata-rata F1-Score 97.77% dan rata-rata HTER 8.47%, sedangkan pada skenario cross-dataset rata-rata F1-Score 74.77% dan rata-rata HTER 29.05%.
description: Indonesia Journal on Computing (Indo-JC), Vol. 5 No. 1 (2020): Maret, 2020
title: Correlation between MRI morphological criteria of malignant breast lesions and their immunohistochemical profile
Creators: name: Settein, Nehal
Publisher: name: European Congress of Radiology
Year: 2020
Subjects: subject: Breast
subject: Breast
subject: MR
subject: Contrast agent-intravenous
subject: Diagnostic procedure
subject: Cancer
subject: Prospective
subject: Cross-sectional study
subject: Performed at one institution

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Immunohistochemical (IHC) markers, together with clinicopathological variables such as tumor size, tumor grade, nodal involvement, histologic type, and surgical margins, have been widely used for prognosis, prediction and treatment selection.(1)(2)...
Intrinsically motivated oculomotor exploration guided by uncertainty reduction and conditioned reinforcement in non-human primates
Creators: name: Daddaoua, Nabil
name: Lopes, Manuel
name: Gottlieb, Jacqueline
Publisher: name: Columbia University
Year: 2016
Subjects: subject: Eye--Movements
subject: Forecasting
subject: Psychology
subject: FOS: Psychology
subject: Primates

description: Intelligent animals have a high degree of curiosity – the intrinsic desire to know – but the mechanisms of curiosity are poorly understood. A key open question pertains to the internal valuation systems that drive curiosity. What are the cognitive and emotional factors that motivate animals to seek information when this is not reinforced by instrumental rewards? Using a novel oculomotor paradigm, combined with reinforcement learning (RL) simulations, we show that monkeys are intrinsically motivated to search for and look at reward-predictive cues, and that their intrinsic motivation is shaped by a desire to reduce uncertainty, a desire to obtain conditioned reinforcement from positive cues, and individual variations in decision strategy and the cognitive costs of acquiring information. The results suggest that free-viewing oculomotor behavior reveals cognitive and emotional factors underlying the curiosity driven sampling of information.
Klasifikasi Kanker Payudara Menggunakan Residual Neural Network
Creators: name: Erwandi, Reynold
name: Suyanto, Suyanto
Publisher: name: Indonesia Journal on Computing (Indo-JC)
Year: 2020

description: Kanker Payudara menjadi salah satu penyebab kematian yang umum terutama pada kaum wanita. Di Amerika Serikat pada tahun 2015, kanker payudara menjadi jenis kanker yang paling banyak diderita dan menjadi kanker paling mematikan setelah kanker paru-paru. Studi terkait menyatakan bahwa pendeteksi dan penanggulangan secara diri menjadi faktor penting dalam menghadapi kanker payudara. Proses diagnosa kanker payudara secara tradisional memakan waktu yang cukup lama, terlebih lagi para ahli patologi belum 100% yakin atas hasil diagnosa mereka. Oleh karena itu dalam penelitian ini dibuatlah sebuah sistem dengan bantuan komputer yang dapat membantu para dokter untuk mengklasifikasi jenis sel payudara berdasarkan gambar histopatologi. Dalam penelitian ini, diusulkan sebuah metode menggunakan pendekatan deep convolutional neural network menggunakan arsitektur Residual Neural Network (ResNet) untuk pengklasifikasian berdasarkan gambar histopatologi pada dataset BreakHis. Performa terbaik yang dicapai dalam metode ini mencapai tingkat rata-rata akurasi 99,3% pada pengklasifikasian binary, dan tingkat rata-rata akurasi 94,6% pada pengklasifikasian multi-class yang mana hampir setara dengan kondisi state-ofthe-art saat penelitian ini ditulis.
description: Indonesia Journal on Computing (Indo-JC), Vol. 5 No. 1 (2020): Maret, 2020
title: Hydrology days award
title: Hydrology days 2015
titleType: AlternativeTitle
title: AGU hydrology days 2015
titleType: AlternativeTitle
Creators: name: Colorado State University, Author
name: Colorado State University, Publisher
Publisher: name: Mountain Scholar
Year: 2015
Subjects: subject: Hydrology -- Congresses
subject: Award winners

description: 2015 annual AGU hydrology days was held at Colorado State University on March 23 - March 25, 2015.
description: The 2015 Hydrology Days Award was presented to Scott W. Tyler.
Encoding Universal Computation in the Ground States of Ising Lattices
Creators: name: Gu, Mile
name: Perales, Alvaro
Publisher: name: arXiv
Year: 2012
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We characterize the set of ground states that can be synthesized by classical 2-body Ising Hamiltonians. We then construct simple Ising planar blocks that simulates efficiently a universal set of logic gates and connections, and hence any boolean function. We therefore provide a new method of encoding universal computation in the ground states of Ising lattices, and a simpler alternative demonstration of the known fact that finding the ground state of a finite Ising spin glass model is NP complete. We relate this with our previous result about emergence properties in infinite lattices.
description: 6 Pages, 1 Figure, fixed notation issues, updated journal reference
Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory
Creators: name: Fá, M.
name: Puzzo, D.
name: Piacentini, R.
name: Staniszewski, Agnieszka
name: Zhang, H.
name: M. A. Baltrons
name: Li Puma, D. D.
name: Chatterjee, I.
name: Li, J.
name: Saeed, F.
name: Berman, Henry L.
name: Ripoli, C.
name: Gulisano, W.
name: Gonzalez, J.
name: Tian, H.
name: Costa, J. A.
name: Lopez, P.
name: Davidowitz, E.
name: Yu, W. H.
name: Haroutunian, V.
name: Brown, L. M.
name: Palmeri, A.
name: Sigurdsson, E. M.
name: Duff, Karen E.
name: Teich, Andrew Franklin
name: Honig, Lawrence S.
name: Sierks, M.
name: Moe, J. G.
name: D’Adamio, L.
name: Grassi, C.
name: Kanaan, N. M.
name: Fraser, P. E.
name: Arancio, Ottavio
Publisher: name: Columbia University
Year: 2016
Subjects: Alzheimer's disease
Nervous system--Degeneration
Oligomers
Biochemistry

description: Non-fibrillar soluble oligomeric forms of amyloid-β peptide (oAβ) and tau proteins are likely to play a major role in Alzheimer’s disease (AD). The prevailing hypothesis on the disease etiopathogenesis is that oAβ initiates tau pathology that slowly spreads throughout the medial temporal cortex and neocortices independently of Aβ, eventually leading to memory loss. Here we show that a brief exposure to extracellular recombinant human tau oligomers (oTau), but not monomers, produces an impairment of long-term potentiation (LTP) and memory, independent of the presence of high oAβ levels. The impairment is immediate as it raises as soon as 20min after exposure to the oligomers. These effects are reproduced either by oTau extracted from AD human specimens, or naturally produced in mice overexpressing human tau. Finally, we found that oTau could also act in combination with oAβ to produce these effects, as sub-toxic doses of the two peptides combined lead to LTP and memory impairment. These findings provide a novel view of the effects of tau and Aβ on memory loss, offering new therapeutic opportunities in the therapy of AD and other neurodegenerative diseases associated with Aβ and tau pathology.
title: Determination of the diagnostic cutoff values of ultrasonographic measurements in posterior interosseous neuropathy (supinator syndrome)
Creators: name: Maletskiy, Eduard
Publisher: name: European Congress of Radiology
Year: 2020
Subjects: subject: Musculoskeletal
subject: Extremities
subject: Musculoskeletal soft tissue
subject: Neuroradiology peripheral nerve
subject: Ultrasound
subject: Diagnostic procedure
subject: Trauma
subject: Prospective
subject: Cross-sectional study
subject: Not applicable

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: To determine the diagnostic cutoff values of ultrasonographic measurements in posterior interosseous...
Eye State Prediction Based on EEG Signal Data Neural Network and Evolutionary Algorithm Optimization
Creators: name: Wisesty, Untari Novia
name: Priabdi, Hifzi
name: Rismala, Rita
name: Sulistiyo, Mahmud Dwi
Publisher: name: Indonesia Journal on Computing (Indo-JC)
Year: 2020

description: Eye state prediction is one study using EEG signals obtained to predict the state of the human eye several moments before. In its development, many researchers also have built eye states detection schemes, but the system built is only limited to classifying one record of input data obtained from the Emotive EPOC headset channel into the eye state. Therefore, this paper proposed eye state prediction system where the system can predict the state of the human eye some time previously based on the EEG signal series used. The proposed system consists of two parts, namely the prediction of the EEG signal value and eye state detection based on the value of the signal that has been obtained using Differential Evolution and Neural Network optimized by Evolution Strategies, respectively. The highest accuracy obtained from the eye state prediction system that has been built is 73.2%. These results are obtained by the best combination of parameters from the three methods used.
description: Indonesia Journal on Computing (Indo-JC), Vol. 5 No. 1 (2020): Maret, 2020
Precision Medicine: Genetic Repair of Retinitis Pigmentosa in PatientDerived Stem Cells
Creators: name: Bassuk, Alexander G.
name: Zheng, Andrew
name: Li, Yao
name: Tsang, Stephen H.
name: Mahajan, Vinit B.
Publisher: name: Columbia University
Year: 2016
Subjects: DNA repair
Retinitis pigmentosa
Stem cells
Biochemistry

description: Induced pluripotent stem cells (iPSCs) generated from patient fibroblasts could potentially be used as a source of autologous cells for transplantation in retinal disease. Patient-derived iPSCs, however, would still harbor disease-causing mutations. To generate healthy patient-derived cells, mutations might be repaired with new gene-editing technology based on the bacterial system of clustered regularly interspersed short palindromic repeats (CRISPR)/Cas9, thereby yielding grafts that require no patient immunosuppression. We tested whether CRISPR/Cas9 could be used in patient-specific iPSCs to precisely repair an RPGR point mutation that causes X-linked retinitis pigmentosa (XLRP). Fibroblasts cultured from a skin-punch biopsy of an XLRP patient were transduced to produce iPSCs carrying the patient’s c.3070G>T mutation. The iPSCs were transduced with CRISPR guide RNAs, Cas9 endonuclease, and a donor homology template. Despite the gene’s repetitive and GC-rich sequences, 13% of RPGR gene copies showed mutation correction and conversion to the wild-type allele. This is the first report using CRISPR to correct a pathogenic mutation in iPSCs derived from a patient with photoreceptor degeneration. This important proof-of-concept finding supports the development of personalized iPSC-based transplantation therapies for retinal disease.
Convex politopes and quantum separability
Creators: name: Holik, Fedrico
name: Plastino, Angel
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We advance a novel perspective of the entanglement issue that appeals to the Schlienz-Mahler measure [Phys. Rev. A 52, 4396 (1995)]. Related to it, we propose an criterium based on the consideration of convex subsets of quantum states. This criterium generalizes a property of product states to convex subsets (of the set of quantum-states) that is able to uncover a new geometrical property of the separability property.