title: ÐÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ð° Ð¸ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð¸Ð·Ð¾ÑÐ¾Ð¿Ð° Ð¼ÐµÐ´Ñ-64 Ð¸ ÑÐ°Ð´Ð¸Ð¾ÑÐ°ÑÐ¼Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ¾Ð² Ð½Ð° ÐµÐ³Ð¾ Ð¾ÑÐ½Ð¾Ð²Ðµ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Features of the production and use of the isotope Cu-64 and radiopharmaceuticals based on it
Creators: name: Ð¦Ð²Ð¸ÑÐ³ÑÐ½, ÐÑÐµÐ½Ð¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: ÑÐ¸ÐºÐ»Ð¾ÑÑÐ¾Ð½
Ð¸Ð·Ð¾ÑÐ¾Ð¿ Ð¼ÐµÐ´Ñ-64
ÑÐ°Ð´Ð¸Ð¾ÑÐ°ÑÐ¼Ð¿ÑÐµÐ¿Ð°ÑÐ°Ñ
ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ð½Ð°Ñ ÑÐµÑÐ°Ð¿Ð¸Ñ
Ð¿Ð¾Ð·Ð¸ÑÑÐ¾Ð½Ð½Ð¾-ÑÐ¼Ð¸ÑÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ¾Ð¼Ð¾Ð³ÑÐ°ÑÐ¸Ñ
ÑÐ°Ð´Ð¸Ð¾Ð¼Ð°ÑÐºÐ¸ÑÐ¾Ð²ÐºÐ°
cyclotron
isotope cu-64
radiopharmaceutical
radionuclide therapy
positron emession tomography
radio marking

description: Ð¢ÐµÐ¼Ð° Ð²ÑÐ¿ÑÑÐºÐ½Ð¾Ð¹ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ: Â«ÐÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ð° Ð¸ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð¸Ð·Ð¾ÑÐ¾Ð¿Ð° Ð¼ÐµÐ´Ñ-64 Ð¸ ÑÐ°Ð´Ð¸Ð¾ÑÐ°ÑÐ¼Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ¾Ð² Ð½Ð° ÐµÐ³Ð¾ Ð¾ÑÐ½Ð¾Ð²ÐµÂ».ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð°Ð½Ð°Ð»Ð¸Ð·Ñ Ð¿ÑÐ¸Ð½ÑÐ¸Ð¿Ð¾Ð² ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ð½Ð¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸ Ð¸ Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÐºÐ¸ Ð¾Ð½ÐºÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ð¹ Ñ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸ÐµÐ¼ ÑÐ°Ð´Ð¸Ð¾ÑÐ°ÑÐ¼Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ¾Ð² Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð¸Ð·Ð¾ÑÐ¾Ð¿Ð° Ð¼ÐµÐ´Ñ-64. ÐÐ°Ð´Ð°ÑÐ¸, ÐºÐ¾ÑÐ¾ÑÑÐµ ÑÐµÑÐ°Ð»Ð¸ÑÑ Ð² ÑÐ¾Ð´Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ:1. Ð¡ÑÐ°Ð²Ð½Ð¸ÑÐµÐ»ÑÐ½ÑÐ¹ Ð°Ð½Ð°Ð»Ð¸Ð· Ð¼ÐµÑÐ¾Ð´Ð¾Ð² Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ð° Ð¸Ð·Ð¾ÑÐ¾Ð¿Ð° Ð¼ÐµÐ´Ñ-642. ÐÐ·ÑÑÐµÐ½Ð¸Ðµ ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ð¾Ð² Ð¸ Ð¾ÑÐ½Ð¾Ð²Ð½ÑÑ Ð¿ÑÐ¸Ð½ÑÐ¸Ð¿Ð¾Ð² ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ð½Ð¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸.3. ÐÐ·ÑÑÐµÐ½Ð¸Ðµ Ð¼ÐµÑÐ¾Ð´Ð¾Ð² ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ¸ ÑÐµÑÐ°Ð¿ÐµÐ²ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¸ Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð Ð¤Ð4. ÐÐ·ÑÑÐµÐ½Ð¸Ðµ Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐµÐ¹ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð¸Ð·Ð¾ÑÐ¾Ð¿Ð° Ð¼ÐµÐ´Ñ-64 Ð² ÐÐ­Ð¢ Ð²Ð¸Ð·ÑÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¸ Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÐºÐµÐÑÐ» Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½ Ð¾Ð±Ð·Ð¾Ñ ÑÐ¾Ð²ÑÐµÐ¼ÐµÐ½Ð½ÑÑ Ð¼ÐµÑÐ¾Ð´Ð¾Ð² ÑÐ´ÐµÑÐ½Ð¾Ð¹ Ð¼ÐµÐ´Ð¸ÑÐ¸Ð½Ñ, ÑÐ°ÐºÐ¸Ñ ÐºÐ°Ðº ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ð½Ð°Ñ ÑÐµÑÐ°Ð¿Ð¸Ñ Ð´Ð»Ñ Ð»ÐµÑÐµÐ½Ð¸Ñ Ð¸ Ð¿Ð¾Ð·Ð¸ÑÑÐ¾Ð½Ð½Ð¾-ÑÐ¼Ð¸ÑÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ¾Ð¼Ð¾Ð³ÑÐ°ÑÐ¸Ñ Ð´Ð»Ñ Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÐºÐ¸. ÐÑÐ¸Ð²ÐµÐ´ÐµÐ½Ð¾ Ð¿Ð¾Ð´ÑÐ¾Ð±Ð½Ð¾Ðµ Ð¾Ð¿Ð¸ÑÐ°Ð½Ð¸Ðµ ÑÑÐ¸Ñ Ð¼ÐµÑÐ¾Ð´Ð¸Ðº, Ð° ÑÐ°ÐºÐ¶Ðµ Ð¾Ð±Ð»Ð°ÑÑÐ¸ Ð¸Ñ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ. ÐÐ»Ñ ÐºÐ°Ð¶Ð´Ð¾Ð³Ð¾ Ð¼ÐµÑÐ¾Ð´Ð° Ð±ÑÐ»Ð¾ Ð¿ÑÐ¸Ð²ÐµÐ´ÐµÐ½Ð¾ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ðµ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸Ðº Ð¸ ÑÐ²Ð¾Ð¹ÑÑÐ² ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ Ð Ð¤Ð, Ð² ÑÐ°ÑÑÐ½Ð¾ÑÑÐ¸, Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð¸Ð·Ð¾ÑÐ¾Ð¿Ð¾Ð² Ð¼ÐµÐ´Ð¸, ÐºÐ¾ÑÐ¾ÑÑÐµ Ð¼Ð¾Ð¶Ð½Ð¾ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°ÑÑ Ð² Ð¾Ð±Ð¾Ð¸Ñ Ð¼ÐµÑÐ¾Ð´Ð°Ñ.Ð ÑÐ¾Ð´Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð±ÑÐ»Ð¸ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ñ Ð¾Ð±Ð»Ð°ÑÑÐ¸ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð¸Ð·Ð¾ÑÐ¾Ð¿Ð° Ð¼ÐµÐ´Ð¸-64 Ð´Ð»Ñ Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÐºÐ¸ Ð¸ Ð»ÐµÑÐµÐ½Ð¸Ñ Ð¾Ð½ÐºÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ð¹ Ñ ÑÐ¾ÑÐºÐ¸ Ð·ÑÐµÐ½Ð¸Ñ ÑÐ¾Ð²ÑÐµÐ¼ÐµÐ½Ð½Ð¾Ð¹ Ð½Ð°ÑÐºÐ¸. Ð¢Ð°Ðº Ð¶Ðµ Ð½ÐµÐºÐ¾ÑÐ¾ÑÑÐµ ÑÐ¾Ð¾Ð±ÑÐ°Ð¶ÐµÐ½Ð¸Ñ Ð½Ð°ÑÑÐµÑ Ð¸Ñ Ð±ÐµÐ·Ð¾Ð¿Ð°ÑÐ½Ð¾Ð³Ð¾ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ñ Ð¸ÑÐºÐ»ÑÑÐµÐ½Ð¸ÐµÐ¼ Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½ÑÑ ÑÐ¸ÑÐºÐ¾Ð² ÑÐ²ÑÐ·Ð°Ð½Ð½ÑÑ Ñ Ð¸Ð½Ð´Ð¸Ð²Ð¸Ð´ÑÐ°Ð»ÑÐ½ÑÐ¼Ð¸ Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÑÐ¼Ð¸ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð².Â 
description: The subject of the graduate qualification work is âFeatures of the production and use of the isotope Cu-64 and radiopharmaceuticals based on itâ.The given work is devoted to the analysis of the principles of radionuclide therapy and the diagnosis of cancer using radiopharmaceuticals based on isotope Cu-64. The research set the following goals:1. Comparative analysis of production methods for the isotope Cu-64.2. Study of radionuclides and main principles of radionuclide therapy.3. Study of methods for developing therapeutic and diagnostic radiopharmaceutical.4. Study of the features of the isotope Cu-64 in PET-imaging and diagnostics.A review was made of modern methods of nuclear medicine, such as radionuclide therapy for treatment and positron emission tomography for diagnosis. A detailed description of these techniques, as well as the scope of their application, is given. For each method, a comparison was made of the characteristics and properties of various radiopharmaceuticals, in particular, based on isotopes Cu, which can be used in both methods.In the course of the study, areas of effective application of the isotope Cu-64 for the diagnosis and treatment of cancer were determined from the point of view of modern science. Also, some considerations about their safe use, with the exception of possible risks associated with the individual characteristics of patients.âÂ