cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of Predictive value of the Adult Comorbidity Evaluation 27 on adverse surgical outcomes and survival in elderly with advanced epithelial ovarian cancer undergoing cytoreductive surgery
Creators: name: Zhao, Mengna
name: Gao, Yang
name: Yang, Junyuan
name: He, Hao
name: Su, Min
name: Wan, Shimeng
name: Feng, Xiaoye
name: Wang, Hua
name: Cai, Hongbing
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 1: Table S1. univariate analysis between different comorbidities and adverse surgical outcomes. Table S2. Characteristics of patients received or not received CRS. Table S3. Log-rank test of OS for selected patients between group of none to moderate and of severe.
title: INVESTMENT FOR TRADE?
title: IMPACT OF INVESTMENT FROM GULF COOPERATION COUNCIL COUNTRIES ON TRADE
titleType: Subtitle
Creators: name: Almodarra, Sattam Faleh
Publisher: name: University of Kentucky
Year: 2017
Subjects: subject: Agribusiness
subject: Agricultural Economics

description: The world has made great progress over the centuries through the massive increase in the interconnectedness of nations around the globe. Today, the world is connected through various ways, including the movement of goods, people, and money. The amount of goods traded across countries borders has drastically increased as the result of technological progress and the removal of barriers to trade. Not only has the world become more interconnected with the physical flows of goods and services, but also countries of the world have become more integrated financially. This study proposes to analyze how increase in financial flows, as measured by Foreign Direct Investment, impact physical flows of goods, as measured by trade. The study focuses on Gulf countries. These countries represent an interesting case study given the structure of their economies, their massive natural resource endowments and heavy reliance on oil and natural gas revenue, and their large sovereign funds. Using panel data for the years 2001-2012 and reliable econometric techniques, the study assesses the impacts of increased investment from Gulf countries on the imports from and exports to partner countries. The results show that both FDI inflows and outflows significantly increase imports to and exports from the Gulf countries. The results are robust to various estimations methods and remain valid for both agricultural and non-agricultural products. The findings of the study provide a better understanding of the trade-investment nexus and shed light on the underlying motives of investment by Gulf countries. Inflows and outflows of investment serve as a strategic option for Gulf countries to both promote their exports while securing their supply in consumer and capital goods.
Informiert und zufrieden? – Auf dem Weg zum mitbestimmenden Nutzer des Gesundheitswesens
Creators: name: Ryl, Livia
name: Horch, Kerstin
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2013
Subjects: subject: 610 Medizin

description: Als Nutzer des Gesundheitswesens nimmt man verschiedene Rollen ein: Patient, Verbraucher, Kunde oder die Person, die gesundheitliche Versorgung bewertet. Der zunehmend stattfindende Wechsel vom eher passiven Patienten zum mitbestimmenden Nutzer von Gesundheitsleistungen erfordert, Beziehungen und Verhaltensweisen im Gesundheitswesen neu zu bestimmen. Im Vordergrund stehen hierbei: Transparenz erhöhen, Kompetenz entwickeln, Rechte der Patientinnen und Patienten stärken, Beschwerdemanagement verbessern. Mit dem im Februar 2013 in Kraft getretenen Patientenrechtegesetz (Bundesgesetzblatt 2013) werden die Einflussmöglichkeiten der Patienten und ihre Rechte auf eine klare gesetzliche Grundlage gestellt. Die neuen Regelungen stärken die Rolle des mündigen Patienten. Wie es bisher mit der Rolle der Patientinnen und Patienten aussah, ermittelte die GEDA (Gesundheit in Deutschland aktuell)-Zusatzbefragung 2009 des RKI „Gesundheitskompetenz und souveränes Handeln im Gesundheitswesen“. Hier wurden Daten zur Zufriedenheit mit dem letzten Kontakt im Gesundheitswesen erhoben. Wissensdefizite in der Bevölkerung hinsichtlich ausgewählter Bereiche des Gesundheitswesens werden mit den Daten deutlich: bei Patientenrechten und bezüglich des Umgangs mit Beschwerden. Diese Defizite variieren nach demographischen und sozioökonomischen Kriterien. Deutlich werden unterschiedliche Bedürfnisse je nach Bevölkerungsgruppe, um Wissen und Kompetenzen zielgruppengerecht vermitteln zu können.
description: Different roles are fulfilled as healthcare user: patient, consumer, customer or a person, who evaluates the healthcare. A change is taking place from a more passive patient to a participant, which requires that relationships and behavior in healthcare need to be redefined. The focus, therefore, is to increase transparency, develop skills, strengthen patients’ rights and improve complaint management. Data about these parameters and the satisfaction with the last contact in the healthcare system were collected in the GEDA 2009 survey „Health literacy and competent acting in healthcare system“ by RKI. Results show deficits in knowledge of selected areas of health care, awareness of patients’ rights and on how to handle complaints. These deficits vary according to demographic and socioeconomic criteria. Therefore it is important to recognize the different needs of population groups in respect of raising knowledge and health literacy.
Drug-induced dementia: a pharmacovigilance analysis of the FAERS database
Creators: name: Wang, Yu
name: Kong, Jiahe
name: Yang, Yi
name: Zheng, Yifan
name: Li, Jia
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Medicine
Neuroscience
Pharmacology
Biotechnology
Science Policy
Mental Health

description: Dementia is a global public health challenge. Certain medications, such as anticholinergics and benzodiazepines, have been linked to an increased dementia risk. However, most studies focused on a limited range of drugs, lacking a comprehensive overview. This article addressed this gap by analyzing drugs associated with dementia using data from the FDA Adverse Event Reporting System (FAERS). The FAERS database was queried using Open Vigil 2.1 to extract reports of drug-induced dementia events from January 2004 to September 2023. Signal detection was performed using Reporting Odds Ratio (ROR) and Proportional Reporting Ratio methods. We analyzed 21,509 reports. There were 163 drugs positively associated with dementia, including neurological drugs (51 drugs, 31.3%), cardiovascular drugs (25 drugs, 15.3%), alimentary tract/metabolism drugs (24 drugs, 14.7%) and genito urinary system/sex hormones drugs (15 drugs, 9.2%). Besides neurological drugs, the drugs with the highest number of reports were apixaban, valsartan and atorvastatin. We found that tamsulosin, alfuzosin, and megestrol may be associated with an increased risk of dementia, and further research is required to clarify these relationships. In clinical practice, it is important to monitor the cognitive status of patients when using drugs that may increase the risk of dementia.
Regelung des Blutspendewesens
Creators: name: Kroczek, Richard
name: Burger, Reinhard
name: Seitz, R.
Publisher: name: Robert Koch-Institut
Year: 1999
Subjects: subject: Transfusionsmedizin
subject: Blutspendewesen
subject: Hämotherapie
subject: 610 Medizin

description: Dieser Beitrag beschreibt die verschiedenen nationalen und europäischen Institutionen, Kommittees, Zulassungsbehörden und Richtlinien, die das deutsche Transfusionssystem regulieren und die für dessen Qualitäts- und Sicherheitsstandards zuständig sind. An erster Stelle steht das „Gesetz zur Regelung des Transfusionswesens (Transfusionsgesetz)” vom 1. Juli 1998. Ein weiteres Regelungselement stellen die „Richtlinien zur Blutgruppenbestimmung und Bluttransfusion (Hämotherapie)” dar, welche vom Wissenschaftlichen Beirat der Bundesärztekammer und dem Paul-Ehrlich-Institut gemeinsam herausgegeben werden. Als ein weiteres Gremium beschäftigt sich der „Arbeitskreis (AK) Blut” mit dem Stand der Technik und Wissenschaft in der Transfusionsmedizin und Hämotherapie. Kompetenzen und Zuständigkeiten der unterschiedlichen Bundes- und Landesbehörden und deren Interaktionsebenen mit den medizinischen Fachgesellschaften werden dargelegt. Schließlich werden die europäischen Organisationen und Kommittees sowohl des Europarates wie auch der Europäischen Union vorgestellt, die an der Erarbeitung europaweiter Standards und Richtlinien für die Transfusionsmedizin beteiligt sind.
description: This article describes the various national and European institutions, committees, guidelines and regulatory bodies shaping and safeguarding the standards of the German transfusion medicine system. It refers to the content of the Transfusion Medicine Act issued in 1998 by the German parliament, the national guidelines of the German Medical Association, and the work of the „Arbeitskreis Blut”, a working party on acute issues arising in the transfusion medicine area. It covers the way the various German federal (Ministry of Health, Paul-Ehrlich-Institut, Robert Koch-Institut) and land regulatory bodies interact with experts of the various German Medical Societies to ensure a high medical standard within the transfusion medicine system. Finally, it describes the European organizations and committees, both within the Council of Europe and the European Union, which are involved in shaping European standards and guidelines in transfusion medicine.
Process Intensification Techniques for Continuous Spherical Crystallization in an Oscillatory Baffled Crystallizer with Online Process Monitoring
Creators: name: Oliva, Joseph A
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Chemical engineering design

description: Guided by the continuous manufacturing paradigm shift in the pharmaceutical industry, the proposed thesis focuses on the implementation of an integrated continuous crystallization platform, the oscillatory baffled crystallizer (OBC), with real time process monitoring. First, by defining an appropriate operating regime with residence time distribution (RTD) measurements, a system can be defined that allows for plug flow operation while also maintaining solid suspension in a two-phase system. The aim of modern crystallization processes, narrow crystal size distributions (CSDs), is a direct result of narrow RTDs. Using a USB microscope camera and principal component analysis (PCA) in pulse tracer experiments, a novel non-contact RTD measurement method was developed using methylene blue. After defining an operating region, this work focuses on a specific process intensification technique, namely spherical crystallization. Used mainly to tailor the size of a final dosage form, spherical crystallization removes the need for downstream size-control based unit operations (grinding, milling, and granulation), while maintaining drug efficacy by tailoring the size of the primary crystals in the agglomerate. The approach for generating spherical agglomerates is evaluated for both small and large molecules, as there are major distinctions in process kinetics and mechanisms. To monitor the spherical agglomeration process, a variety of Process Analytical Technology (PAT) tools were used and the data was implemented for scale-up applications. Lastly, a compartmental model was designed based on the experimental RTD data with the intention of predicting OBC mixing and scale-up dynamics. Together, with validation from both the DN6 and DN15 systems, a scale independent equation was developed to predict system dispersion at different mixing conditions. Although it accurately predicts the behavior of these two OBC systems, additional OBC systems of different scale, but similar geometry should be tested for validation purposes.
sj-pdf-2-eso-10.1177_23969873211024777 - Supplemental material for Correlation between acute ischaemic stroke clot length before mechanical thrombectomy and extracted clot area: Impact of thrombus size on number of passes for clot removal and final recanalization
Creators: name: Rossi, Rosanna
name: Fitzgerald, Seán
name: Gil, Sara M
name: Mereuta, Oana M
name: Douglas, Andrew
name: Pandit, Abhay
name: Brennan, Paul
name: Power, Sarah
name: Alderson, Jack
name: O’Hare, Alan
name: Gilvarry, Michael
name: McCarthy, Ray
name: Psychogios, Klearchos
name: Magoufis, Georgios
name: Tsivgoulis, Georgios
name: Szikora, István
name: Jood, Katarina
name: Redfors, Petra
name: Nordanstig, Annika
name: Ceder, Erik
name: Tatlisumak, Turgut
name: Rentzos, Alexandros
name: Thornton, John
name: Doyle, Karen M
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Cardiology
subject: Medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-2-eso-10.1177_23969873211024777 for Correlation between acute ischaemic stroke clot length before mechanical thrombectomy and extracted clot area: Impact of thrombus size on number of passes for clot removal and final recanalization by Rosanna Rossi, Seán Fitzgerald, Sara M Gil, Oana M Mereuta, Andrew Douglas, Abhay Pandit, Paul Brennan, Sarah Power, Jack Alderson, Alan O’Hare, Michael Gilvarry, Ray McCarthy, Klearchos Psychogios, Georgios Magoufis, Georgios Tsivgoulis, István Szikora, Katarina Jood, Petra Redfors, Annika Nordanstig, Erik Ceder, Turgut Tatlisumak, Alexandros Rentzos, John Thornton and Karen M Doyle in European Stroke Journal
sj-docx-2-emr-10.1177_17540739211022815 – Supplemental material for Horror Films and Grief
Creators: name: Millar, Becky
name: Lee, Jonny
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Anthropology
subject: FOS: Sociology
subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: Sociology

description: Supplemental material, sj-docx-2-emr-10.1177_17540739211022815 for Horror Films and Grief by Becky Millar and Jonny Lee in Emotion Review
Additional file 2 of Predictive value of the Adult Comorbidity Evaluation 27 on adverse surgical outcomes and survival in elderly with advanced epithelial ovarian cancer undergoing cytoreductive surgery
Creators: name: Zhao, Mengna
name: Gao, Yang
name: Yang, Junyuan
name: He, Hao
name: Su, Min
name: Wan, Shimeng
name: Feng, Xiaoye
name: Wang, Hua
name: Cai, Hongbing
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 2: Fig. S1. Receiver operator characteristic curve for Clavien–Dindo grade III–V complications or unintended ICU admission. Fig. S2. (a-d) Kaplan–Meier (K-M) survival curves of overall survival for selected patients. a. K-M survival curve for patients stratified by aged. b. K-M survival curve for patients stratified by BMI. c. K-M survival curve for patients stratified by FIGO stage. d. K-M survival curve for patients stratified by pathology.
Epidemiology of campylobacteriosis in Germany – insights from 10 years of surveillance
Creators: name: Schielke, Anika
name: Rosner, Bettina
name: Stark, Klaus
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2014
Subjects: subject: Germany
subject: Epidemiology
subject: Surveillance
subject: Campylobacter
subject: 610 Medizin

description: Background: Campylobacteriosis caused by Campylobacter spp. is the most common notifiable bacterial gastrointestinal disease in Germany and a major problem in many other European countries as well. In contrast to other infectious diseases, e.g., salmonellosis, the annual number of notified campylobacteriosis cases has increased in Germany and other European countries from 2001–2010. Methods: National surveillance data from 2001 through 2010 were the basis of a detailed description of the epidemiological pattern of Campylobacter infections in Germany. Special focus was placed on geographical distribution and time trends of Campylobacter infections as well as the identification of risk groups. Results: In total, 588,308 cases of campylobacteriosis were recorded during the observed time period. The mean annual incidence increased from 67 cases/100,000 population in 2001 to 80/100,000 population in 2010. Almost 92% of the notified Campylobacter infections were acquired in Germany. A seasonal distribution was observed with a large peak in the summer months and a small peak in January. Incidence was highest in children ≤4 years and young adults 20–29 years of age. Especially young children living in rural regions in Germany seemed to be at high risk of Campylobacter infection. Conclusions: Campylobacter is the leading cause of bacterial gastroenteritis in Germany, and has been of rising public health concern. There is a need for enhanced prevention of Campylobacter infections and the data presented here may contribute to better target prevention measures with focus on identified risk groups such as children and young adults.
A Comparison of CFA and ESEM Approaches Using TIMSS Science Attitudes Items: Evidence from Factor Structure and Measurement Invariance
Creators: name: Jung, Ji Yoon
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Educational psychology

description: The power of positive attitudes toward science is that they influence science achievement by reinforcing higher performance. Interestingly, there continue to be gender disparities in attitudes toward science across many countries. Males generally have more positive attitudes toward science than females. Although most research related to attitudes toward science have been based on the Trends in International Mathematics and Science Study (TIMSS) Student Questionnaire, there remains a dearth of evidence validating the TIMSS science attitudes items and measurement equivalence across genders. The goals of this research were as follows: (1) to build support for the structural validity of the TIMSS items, and (2) to investigate whether the instrument measures the same latent construct (attitudes toward science) across genders. The present study followed two steps of statistical analyses. As a first step, two modeling methods (confirmatory factor analysis and exploratory structural equation modeling) were conducted to identify the best-fitting model for the instrument. Second, after determining the model of choice, we tested several nested invariance models progressively. This study found (1) the latent factor structure of the TIMSS items and (2) strong measurement invariance across genders. This result indicated that the instrument is well designed by the a priorispecification and measures the same latent variable for both female and male students. This study provides support for the multidimensional approach to measuring science attitudes and shows the flexibility of ESEM over CFA by demonstrating that the ESEM approach provided better representation of the underlying factor structure.
Drug-induced dementia: a pharmacovigilance analysis of the FAERS database
Creators: name: Wang, Yu
name: Kong, Jiahe
name: Yang, Yi
name: Zheng, Yifan
name: Li, Jia
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Medicine
Neuroscience
Pharmacology
Biotechnology
Science Policy
Mental Health

description: Dementia is a global public health challenge. Certain medications, such as anticholinergics and benzodiazepines, have been linked to an increased dementia risk. However, most studies focused on a limited range of drugs, lacking a comprehensive overview. This article addressed this gap by analyzing drugs associated with dementia using data from the FDA Adverse Event Reporting System (FAERS). The FAERS database was queried using Open Vigil 2.1 to extract reports of drug-induced dementia events from January 2004 to September 2023. Signal detection was performed using Reporting Odds Ratio (ROR) and Proportional Reporting Ratio methods. We analyzed 21,509 reports. There were 163 drugs positively associated with dementia, included neurological drugs (52 drugs, 31.9%), cardiovascular drugs (25 drugs, 15.3%), alimentary tract/metabolism drugs (24 drugs, 14.7%) and genito urinary system/sex hormones drugs (15 drugs, 9.2%). Besides neurological drugs, the drugs with the highest number of reports are apixaban, valsartan and atorvastatin. We found that tamsulosin, alfuzosin, and megestrol may be associated with an increased risk of dementia, and further research is required to clarify these relationships. In clinical practice, it is important to monitor the cognitive status of patients when using drugs that may increase the risk of dementia.
Expression-analysis of the human endogenous retrovirus HERV-K in human astrocytic tumors
Creators: name: Kessler, Almuth Friederike
name: Wiesner, Miriam
name: Denner, Joachim
name: Kämmerer, Ulrike
name: Vince, Giles Hamilton
name: Linsenmann, Thomas
name: Löhr, Mario
name: Ernestus, Ralf-Ingo
name: Hagemann, Carsten
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2014
Subjects: subject: HERV-K
subject: Human endogenous retrovirus
subject: Glioblastoma multiforme
subject: Astrocytic tumor
subject: Expression
subject: Glioblastoma cell line
subject: PCR analysis
subject: 610 Medizin

description: Background: The human endogenous retrovirus K (HERV-K) has been acquired by the genome of human ancestors million years ago. It is the most complete of the HERVs with transcriptionally active gag, pol and env genes. Splice variants of env, which are rec, 1.5 kb transcript and Np9 have been suggested to be tumorigenic. Transcripts of HERV-K have been detected in a multitude of human cancers. However, no such reports are available concerning glioblastomas (GBM), the most common malignant brain tumor in adults. Patients have a limited prognosis of 14.6 months in median, despite standard treatment. Therefore, we elucidated whether HERV-K transcripts could be detected in these tumors and serve as new molecular target for treatment. Findings: We analyzed human GBM cell lines, tissue samples from patients and primary cell cultures of different passages for HERV-K full length mRNA and env, rec and 1.5 kb transcripts. While the GBM cell lines U138, U251, U343 and GaMG displayed weak and U87 strong expression of the full length HERV-K, the splice products could not be detected, despite a weak expression of env mRNA in U87 cells. Very few tissue samples from patients showed weak expression of env mRNA, but none of the rec or 1.5 kb transcripts. Primary cells expressed the 1.5 kb transcript weakly in early passages, but lost HERV-K expression with extended culture time. Conclusions: These data suggest that HERV-K splice products do not play a role in human malignant gliomas and therefore, are not suitable as targets for new therapy regimen.
sj-pdf-2-hsr-10.1177_13558196211029323 - Supplemental material for Getting the whole story: Integrating patient complaints and staff reports of unsafe care
Creators: name: Van Dael, Jackie
name: Gillespie, Alex
name: Reader, Tom
name: Smalley, Katelyn
name: Papadimitriou, Dimitri
name: Glampson, Ben
name: Marshall, Daniel
name: Mayer, Erik
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified

description: Supplemental material, sj-pdf-2-hsr-10.1177_13558196211029323 for Getting the whole story: Integrating patient complaints and staff reports of unsafe care by Jackie Van Dael, Alex Gillespie, Tom Reader, Katelyn Smalley, Dimitri Papadimitriou, Ben Glampson, Daniel Marshall and Erik Mayer in Journal of Health Services Research & Policy
Fall incidence in Germany: results of two population-based studies, and comparison of retrospective and prospective falls data collection methods
Creators: name: Rapp, Kilian
name: Freiberger, Ellen
name: Todd, Chris
name: Klenk, Jochen
name: Becker, Clemens
name: Denkinger, Michael
name: Scheidt-Nave, Christa
name: Fuchs, Judith
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2014
Subjects: subject: Epidemiology
subject: Population-based
subject: Accidental falls
subject: Independent living
subject: 610 Medizin

description: Background: Fall incidence differs considerably between studies and countries. Reasons may be differences between study samples or different assessment methods. The aim was to derive estimates of fall incidence from two population-based studies among older community-living people in Germany and compare retrospective and prospective falls data collection methods. Methods: Data were derived from the 2008–11 wave of the German health interview and examination survey for adults (DEGS1), and the Activity and Function of the Elderly in Ulm study (ActiFE-Ulm). Data collection took place in community facilities (DEGS1) or participants’ homes (ActiFE-Ulm). Participation rates were 42% (newly recruited) and 64% (panel component) in DEGS1 and 19.8% in ActiFE-Ulm. Self-report retrospective fall data covering the previous 12 month period in DEGS1 and ActiFE-Ulm were collected, but only ActiFE-Ulm used prospective 12 month fall calendars. The incidence of ‘any fall’ and ‘recurrent falls’ were calculated for both methods. Results: Fall rates increased with age in men but not women. The ActiFE-Ulm prospectively assessed incidence (95% confidence interval) in women and men aged 65-
Real-world pharmacovigilance study of FDA adverse event reporting system events for finerenone
Creators: name: Huang, Youqi
name: Gao, Hongjin
name: Lin, Yuze
name: Chen, Xiaowen
name: Chen, Mingyu
name: Chen, Min
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: This study analyzed the signal mining of adverse events caused by finerenone based on the US Food and Drug Administration Adverse Event Reporting System (FAERS) and evaluated the drug’s safety to provide a reference for the safe administration of this medication in medical institutions. FAERS data from the third quarter of 2021 to the fourth quarter of 2023 were used, and the adverse event codes of the Medical Dictionary for Regulatory Activities were compared. After the data were processed, adverse event reports that featured finerenone as the most suspected drug were extracted. A total of 905 reported cases of adverse events including finerenone as the first suspected drug were extracted. The ratio of male to female patients was 1.25, and most were aged 65–85 years (30.1%). The adverse events that were reported more frequently with positive signals were decreased glomerular filtration rate, hyperkalemia, increased blood creatinine, and dizziness. The adverse events that were concentrated on in investigations were metabolism and nutrition disorders and diseases of the renal and urinary system. Our study identified significant novel adverse events (AEs) signals for finerenone that could provide support for clinical monitoring of and risk identification for finerenone.
INTELIGÊNCIA ARTIFICIAL: SOLUÇÕES EM COMUNICAÇÃO ATRAVÉS DE BOTS E CHATGPT
Creators: name: de Sousa e Silva Filho, Luis
Publisher: name: Zenodo
Year: 2024
Subjects: Inteligência Artificial
Bots
ChatGPT

description: Este trabalho de conclusão de curso abordou soluções em comunicação na sociedade brasileira através da Inteligência Artificial (IA). Como objetivo principal, o autor precisava apontar quais os setores da sociedade brasileira foram mais impactados com a chegada da Inteligência Artificial. O primeiro objetivo específico buscou mostrar se o uso da Inteligência Artificial tem sido ampliado no Brasil, por meio de smartphones. Sendo este artigo relacionado a um Curso Superior de Linguagem, com habilitação em Português e Inglês, o segundo objetivo específico buscou esclarecer se os ChatBots têm facilitado a fluência na Língua Inglesa.
Application of the screening method to monitor influenza vaccine effectiveness among the elderly in Germany
Creators: name: Remschmidt, Cornelius
name: Rieck, Thorsten
name: Bödeker, Birte
name: Wichmann, Ole
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2015
Subjects: subject: Influenza
subject: Vaccine effectiveness
subject: Elderly
subject: Screening method
subject: 610 Medizin

description: Background: Elderly people are at increased risk for severe influenza illness and constitute therefore a major target-group for seasonal influenza vaccination in most industrialized countries. The aim of this study was to estimate influenza vaccine effectiveness (VE) among individuals aged 60+ years over three seasons and to assess if the screening method is a suitable tool to monitor influenza VE in this particular target-group in Germany. Methods: We identified laboratory-confirmed influenza cases aged 60+ years through the national communicable disease reporting system for seasons 2010/11, 2011/12 and 2012/13. Vaccination coverage (VC) data were retrieved from a database of health insurance claims representing ~85% of the total German population. We applied the screening method to calculate influenza subtype-specific VE and compared our results with VE estimates from other observational studies in Europe. Results: In total, 7,156 laboratory-confirmed influenza cases were included. VE against all influenza types ranged between 49% (95% confidence interval [CI]: 39–56) in 2011/12 and 80% (95% CI: 76-83%) in 2010/11. In 2010/11 subtype-specific VE against influenza A(H1N1)pdm and B was 76% and 84%, respectively. In the following seasons, VE against influenza A(H1N1)pdm, A(H3N2) and B was 87%, -9% , 74% (2011/12), and 74%, 39%, 73% (2012/13). VE was higher among hospitalized compared to non-hospitalized influenza A cases. Seventeen observational studies from Europe reporting subtype-specific VE among the elderly were identified for the respective seasons (all applying the test-negative design) and showed comparable subtype-specific VE estimates. Conclusions: According to our study, influenza vaccination provided moderate protection against laboratory-confirmed influenza A(H1N1)pdm and B in individuals aged 60+ but no or only little protection against A(H3N2). Higher VE among hospitalized cases might indicate higher protection against severe influenza disease. Based on the available data, the screening method allowed us to assess subtype-specific VE in hospitalized and non-hospitalized elderly persons. Since controlling for several important confounders was not possible, the applied method only provided crude VE estimates. However, given the precise VC-data and the large number of cases, the screening method provided results being in line with VE estimates from other observational studies in Europe that applied a different study design.
Additional file 2 of A cost-effectiveness analysis of patiromer in the UK: evaluation of hyperkalaemia treatment and lifelong RAASi maintenance in chronic kidney disease patients with and without heart failure
Creators: name: Ward, Thomas
name: Lewis, Ruth D.
name: Brown, Tray
name: Baxter, Garth
name: de Arellano, Antonio Ramirez
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Pharmacology
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Marine Biology
Science Policy

description: Additional file 2: This appendix provides details of cost data utilised in the model.
Use of signal detection methods to identify associations between prenatal medication exposure and subsequent childhood cancers: a Nordic hypothesis-generating registry-based study
Creators: name: Johnson, Hannah
name: Hjorth, Sarah
name: Morris, Joan
name: Pottegård, Anton
name: Leinonen, Maarit
name: Norby, Ulrika
name: Nordeng, Hedvig
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Childhood cancer is an important contributor to childhood mortality in high-income countries. Information on associations between childhood cancer and in-utero exposure is absent or limited for most medications. Signal detection methods identify medications where research should be focused but have not been applied to datasets containing prenatal medication exposures and childhood cancers. The aim of this study was to apply and evaluate four signal detection methods – odds ratios (OR), the information component (IC), sequential probability ratio testing (SPRT), and Bayesian hierarchical models (BHM) – for identification of associations between medications dispensed during pregnancy and subsequent, incident diagnosis of childhood cancer <10 years, using linked Nordic registry data. Signal detection results were compared to propensity score adjusted odds ratios from generalized linear models. Analysis was performed for 117 medication-cancer pairs with 5 or more observations. The OR had the greatest sensitivity (0.75). The IC had a greater specificity (0.98) than the OR (0.95). The IC may be the most appropriate method for identifying signals within this type of data. Reported signals should not be considered sufficient evidence of causal association and must be followed-up by tailored investigations that consider confounding by indication.
sj-pdf-1-asq-10.1177_00018392211029930 – Supplemental material for Economic Consequences and the Motive to Discriminate
Creators: name: Stroube, Bryan K.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business

description: Supplemental material, sj-pdf-1-asq-10.1177_00018392211029930 for Economic Consequences and the Motive to Discriminate by Bryan K. Stroube in Administrative Science Quarterly
sj-pdf-1-inc-10.1177_17511437211031841 - Supplemental material for Animation supported communication on intensive care; a service improvement initiative
Creators: name: Wachtl, Marta
name: Ledesma, Frances
name: Malcolm, Hannah
name: Toal, Connor
name: Kavanagh, Charlotte
name: Hadley, Julia
name: Pennington, James
name: Shepherd, Stephen
name: Wald, David S
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: Cardiology
subject: 110305 Emergency Medicine
subject: FOS: Clinical medicine
subject: 110323 Surgery

description: Supplemental material, sj-pdf-1-inc-10.1177_17511437211031841 for Animation supported communication on intensive care; a service improvement initiative by Marta Wachtl, Frances Ledesma, Hannah Malcolm, Connor Toal, Charlotte Kavanagh, Julia Hadley, James Pennington, Stephen Shepherd and David S Wald in Journal of the Intensive Care Society
Additional file 3 of A cost-effectiveness analysis of patiromer in the UK: evaluation of hyperkalaemia treatment and lifelong RAASi maintenance in chronic kidney disease patients with and without heart failure
Creators: name: Ward, Thomas
name: Lewis, Ruth D.
name: Brown, Tray
name: Baxter, Garth
name: de Arellano, Antonio Ramirez
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Pharmacology
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Marine Biology
Science Policy

description: Additional file 3: This appendix provides details of utility and disutility input parameters utilised in the model.
A rational approach to estimate reasonable design values of selected joints by using lower tolerance limits
Creators: name: Uysal, Mesut
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Wood processing
Engineering design

description: Lower tolerance limits (LTLs) methods was used to estimate design values of furniture joints. To have higher reliability in joint, LTLs were chosen for higher confidence/proportional level. The logic behind phenomena is that if stress on joint exceeds the given LTLs, failure on joints is most likely observed. Therefore, joint sizes were determined to maintain internal stresses on joint below LTLs value corresponding to external load.
Pulmonary adverse events associated with monoclonal antibodies approved for multiple myeloma: a pharmacovigilance study based on the FDA adverse event reporting system
Creators: name: Liang, Ting
name: Yan, Limei
name: Li, Junfeng
name: Gai, Dongzheng
name: Xu, Cong
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: The emergence of monoclonal antibodies has notably enhanced the outcomes for multiple myeloma. However, comprehensive assessment of monoclonal antibody-related pulmonary adverse events remains scarce. This pharmacovigilance study analyzed adverse event data of monoclonal antibodies approved for myeloma from 1 January 2016, to 31 December 2023, using OpenVigil 2.1. Adverse event reports were classified based on the MedDRA v24.0 into five pulmonary SMQs: asthma/bronchospasm, infective pneumonia, interstitial lung disease, pulmonary hypertension, and respiratory failure. Disproportionality analyses were utilized to identify potential risk signals. A total of 8,043,250 reports were extracted. Male patients and those aged ≥ 65 years were predominant. Hospitalization and death were common outcomes. Elranatamab had the highest risk for infective pneumonia, elotuzumab had the highest risk for interstitial lung disease, and isatuximab had the highest risk for respiratory failure. Significant associations were discovered between pulmonary adverse events and all five monoclonal antibodies. Viral pneumonia was most prevalent with daratumumab, fungal pneumonia was predominant with elotuzumab, and bacterial pneumonia was predominant with isatuximab, teclistamab, and elranatamab. This study summarized significant pulmonary adverse event signals associated with monoclonal antibodies approved for myeloma, emphasizing the significance of monitoring interstitial lung disease, respiratory failure, and infective pneumonia.
sj-docx-1-nms-10.1177_14614448211027963 – Supplemental material for Algorithmic personalization of source cues in the filter bubble: Self-esteem and self-construal impact information exposure
Creators: name: Knobloch-Westerwick, Silvia
name: Westerwick, Axel
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications

description: Supplemental material, sj-docx-1-nms-10.1177_14614448211027963 for Algorithmic personalization of source cues in the filter bubble: Self-esteem and self-construal impact information exposure by Silvia Knobloch-Westerwick and Axel Westerwick in New Media & Society
Shakespeare in "As You Like It" made "more agreeable" preserves Marlowe's denouement in Hero and Leander"
Creators: name: Willis, Rich
Publisher: name: Humanities Commons
Year: 2021

description: Shakespeare's As You Like It breathed abroad preserves Marlowe's denouement in his tragedy of Leander from a Ganymede turned.
Gender in Equestria: An Examination of Reconstituted Forms of Masculinity and Their Consequences for Gender Relations in the Brony Community
Creators: name: Palmer, Zachary D
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Sociology not elsewhere classified

description: In this dissertation, I analyze the Brony community to better understand reconstituted forms of masculinity. Specifically, I focus on the following questions: What does it mean when men incorporate what has traditionally been viewed as stigmatized or feminine into their gender presentations? How do these forms of masculinity represent a challenge to gender politics and how do they reinforce gender inequality? How do women navigate spaces defined by reconstituted forms of masculinity? In what ways do women within these spaces both challenge and maintain power relations? I address these questions through an analysis of interviews with 43 men and women who are fans of My Little Pony and ethnographic observations at four My Little Pony fan conventions. In doing so, this dissertation nuances and extends the literature on reconstituted forms of masculinity, including hybrid masculinities.
Additional file 2 of Potential biomarker proteins for aspiration pneumonia detected by shotgun proteomics using buccal mucosa samples: a cross-sectional case–control study
Creators: name: Ogura, Kohei
name: Endo, Maho
name: Hase, Takashi
name: Negami, Hitomi
name: Tsuchiya, Kohsuke
name: Nishiuchi, Takumi
name: Suzuki, Takeshi
name: Ogai, Kazuhiro
name: Sanada, Hiromi
name: Okamoto, Shigefumi
name: Sugama, Junko
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Additional file 2: Figure S1. Distribution of abundance. This figure was prepared by Proteome Discoverer software version 2.2.0.388 (Thermo Fisher Scientific). Figure S2. Volcano plots of the proteomic data. The plots were generated using the abundance ratio = Log2(AP/Control). P values were calculated by ANOVA and adjusted by the Benjamini–Hochberg method in Proteome Discoverer software version 2.2.0.388 (Thermo Fisher Scientific). Figure S3. Principal component analysis of the 12 samples. This figure was prepared by Proteome Discoverer software version 2.2.0.388 (Thermo Fisher Scientific).
Assessment of physicians’ knowledge, thoughts, and attitudes regarding the phytovigilance system
Creators: name: Gökkaya, İçim
name: Özceylan, Ömer Faruk
name: Çolak, Beyza
name: Renda, Gülin
name: Duman, Mine
name: Duman, Erdem Nail
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: In this study, physicians’ awareness of phytovigilance and their knowledge of safety processes for herbal products were evaluated for the first time in Türkiye. A descriptive quantitative study was conducted using face-to-face interview techniques with physicians working in a training and research hospital in Türkiye. A total of 268 (35.2%) questionnaires with appropriate data quality were analyzed with IBM SPSS Statistics 23.0. The factors that had the strongest effect on phytovigilance awareness were determined by binary logistic regression analysis. Values of p < 0.05 were accepted as statistically significant. The survey results revealed that 45.5% of physicians were aware of the concept of phytovigilance. Physicians who knew that adverse effects were reported due to the use of herbal products, physicians who asked about the use of herbal products while taking their patients’ medical history, and specialist physicians had higher awareness of the concept of phytovigilance. Only 30.2% of participants were aware that feedback on adverse reactions from herbal products was being collected and only 27.2% were aware that there was a phytovigilance contact point in the hospital. The awareness of physicians regarding phytovigilance should be increased. Physicians should ask about the use of herbal products while taking medical history, identify possible adverse effects associated with herbal products, and provide feedback.
Additional file 1 of Quality of life of COVID-19 recovered patients: a 1-year follow-up study from Bangladesh
Creators: name: Hawlader, Mohammad Delwer Hossain
name: Rashid, Md Utba
name: Khan, Md Abdullah Saeed
name: Liza, Mowshomi Mannan
name: Akter, Sharmin
name: Hossain, Mohammad Ali
name: Rahman, Tajrin
name: Barsha, Sabrina Yesmin
name: Shifat, Alberi Afifa
name: Hossian, Mosharop
name: Mishu, Tahmina Zerin
name: Sagar, Soumik Kha
name: Manna, Ridwana Maher
name: Ahmed, Nawshin
name: Debu, Sree Shib Shankar Devnath
name: Chowdhury, Irin
name: Sabed, Samanta
name: Ahmed, Mashrur
name: Borsha, Sabrina Afroz
name: Al Zafar, Faraz
name: Hyder, Sabiha
name: Enam, Abdullah
name: Babul, Habiba
name: Nur, Naima
name: Haque, Miah Md. Akiful
name: Roy, Shopnil
name: Tanvir Hassan, K. M.
name: Rahman, Mohammad Lutfor
name: Nabi, Mohammad Hayatun
name: Dalal, Koustuv
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Figure S1. Flow chart of participant selection and data collection. Figure S2. Pattern of change in score in physical, psychological, social and environmental domains of quality of life. Figure S3. Pattern of changes in overall quality of life and health satisfaction over the period. Figure S4. Onset of new chronic disease and percentage of re-infection among the recovered COVID-19 participants during second follow-up.
Assessment of Physicians’ knowledge, thoughts, and attitudes regarding the phytovigilance system
Creators: name: Gökkaya, İçim
name: Özceylan, Ömer Faruk
name: Çolak, Beyza
name: Renda, Gülin
name: Duman, Mine
name: Duman, Erdem Nail
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: In this study, physicians’ awareness of phytovigilance and their knowledge of safety processes for herbal products were evaluated for the first time in Türkiye. A descriptive quantitative study was conducted using face-to-face interview techniques with physicians working in a training and research hospital in Türkiye. A total of 268 (35.2%) questionnaires with appropriate data quality were analyzed with IBM SPSS Statistics 23.0. The factors that had the strongest effect on phytovigilance awareness were determined by binary logistic regression analysis. Values of p < 0.05 were accepted as statistically significant. The survey results revealed that 45.5% of physicians were aware of the concept of phytovigilance. Physicians who knew that adverse effects were reported due to the use of herbal products, physicians who asked about the use of herbal products while taking their patients’ medical history, and specialist physicians had higher awareness of the concept of phytovigilance. Only 30.2% of participants were aware that feedback on adverse reactions from herbal products was being collected and only 27.2% were aware that there was a phytovigilance contact point in the hospital. The awareness of physicians regarding phytovigilance should be increased. Physicians should ask about the use of herbal products while taking medical history, identify possible adverse effects associated with herbal products, and provide feedback.