cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Characterizing the Targets of UNC0621, a small molecule modulator of chromatin accessibility in Ewing Sarcoma
Creators: name: Valerie Nguyen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Ewing sarcoma (EwS) is a highly aggressive bone cancer in children and young adults characterized by a chromosomal translocation that generates the fusion oncoprotein EWS-FLI. The EWS-FLI oncoprotein is retargeted to genomic loci where it mediates aberrant chromatin accessibility. Previously, we identified UNC0621 as a small molecule capable of decreasing EWS-FLI-mediated chromatin accessibility and EwS cell proliferation. However, the mechanism of action and targets of UNC0621 were unknown. Using chemo proteomic methods, we identified numerous RNA binding proteins, including hnRNPH1 and hnRNPC, as potential interactors of UNC0621. Using a CRISPR-based inhibition system (CRISPRi), we sought out to determine if knockdown of hnRNPH1 and hnRNPC phenocopy the effects of UNC0621 on EwS cell proliferation and EWS-FLI-mediated chromatin accessibility. Determination of the target of UNC0621 not only provides potential targets for further pharmaceutical development, but also provides further insights into Ewing sarcoma biology.
Quantum reflection of photons off spatio-temporal electromagnetic field inhomogeneities
Creators: name: Gies, Holger
name: Karbstein, Felix
name: Seegert, Nico
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We reconsider the recently proposed nonlinear QED effect of quantum reflection of photons off an inhomogeneous strong-field region. We present new results for strong fields varying both in space and time. While such configurations can give rise to new effects such as frequency mixing, estimated reflection rates based on previous one-dimensional studies are corroborated. On a conceptual level, we critically re-examine the validity regime of the conventional locally-constant-field approximation and identify kinematic configurations which can be treated reliably. Our results further underline the discovery potential of quantum reflection as a new signature of the nonlinearity of the quantum vacuum.
description: 19 pages, 7 figures
Musical Mediation: Fado as an Agent of Self-elaboration and Reconciliation
Creators: name: Collins, Caroline
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: The Portuguese music “fado” is a highly ambiguous and anthropomorphized genre.  It is deeply emblematic of a collective Portuguese identity and is characterized by sentiments of nostalgia and longing (Gray 2013). The ambiguity within the genre not only renders fado highly available for interpretation and expression, but also foregrounds self-realization on individual and national levels. This conflation of identity and genre enables fado to serve as a mediation between fragmented spaces and times, informing and reconciling the identities of its participants. 
My paper explores two primary modes through which this phenomenon may occur: the performance of traditional fado and experimental fado. I evaluate these two types of fado via a case study of two communities: the Portuguese community in the San Francisco Bay area, which embodies traditional practices, and the group Fado Bicha (and their listeners) in the Alfama district in Lisbon, Portugal. This group utilizes experimental approaches to fado performance. 
 While many fado practitioners deem the two styles incompatible, I propose that they are complementary. Both offer musical presentation, interpretation, and styling as an avenue through which individual and national identities may be formed and informed.  The musical style of each approach not only signifies the distinct capacities for reconciliation and mediation offered in the differing expressions, but also indexes the audiences who may benefit from an interaction with that music.
My research methodologies included in-person and virtual interviews, as well as sound studies of live and virtual fado performances.

Gray, Lila Ellen. 2013. Fado Resounding: Affective Politics and Urban Life. New York, USA: Duke University Press.
(501499) George Prosser
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(501496) George Philip Browne
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Cancel Culture or Consequence Culture: Its Pervasive Presence in the Book Publishing and Entertainment Industry and its Effects on Social Media
Creators: name: Deol, Anissa
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Cancel culture is a growing phenomenon that has been debated on all social media platforms since as early as 2015. It has divided groups on ideals about politicians, celebrities, and has even been seen by some as an infringement on free speech. In this thesis, I analyze the causes of cancel culture as they are presented on social media, specifically Twitter, while simultaneously analyzing content and creators who have been called to be canceled. The creators analyzed are Dr. Seuss, Jay Kristoff, Tim Burton and Dave Chapelle, and the content connected to the creators that was analyzed were Stormdancer: The Lotus War by Jay Kristoff, And to Think That I Saw It on Mulberry Street and If I Ran the Zoo by Dr. Seuss, Miss Peregrine's Home for Peculiar Children, directed by Tim Burton, and Dave Chapelle’s The Closer. Given that I focused on five different pieces of content, I divided my analysis into three different methodological practices: content analysis, textual analysis, and sentiment analysis. Within these analyses, I examined literature referring to cancel culture within the book publishing and entertainment industries, and further participated in my own analysis based on the case studies mentioned above. Additionally, this study demonstrates what role social media plays in swaying people into what content they should consume or refuse to consume. The results of this study explore specific trends and themes within each piece of content using the code, category, and theme analysis, and expands on what social media can say about consumerism within these two industries.
Higher Derivative Terms in Three Dimensional Supersymmetric Theories
Creators: name: Awad, Adel
name: Faizal, Mir
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this work, we systematically analyze higher derivative terms in the supersymmetric effective actions for three dimensional scalar field theories using $\mathcal{N} =1$ superspace formalism. In these effective actions, we show that auxiliary fields do not propagate and their effective actions can be expressed in terms of the physical fields. So, the theory does not change its field content upon addition of higher derivative terms. We use derivative expansion to generate four, five and six dimensional terms for an interacting scalar field theory with $\mathcal{N} =1$ supersymmetry. We show that along with pure fermionic and bosonic terms, there are various five and six dimensional topological terms that mix bosonic and fermionic fields. Finally, we use these results to obtain higher derivative topological terms in the effective action for two M2-branes.
description: 18 pages, 0 figures, Accepted for publication in JHEP
Optimization of CRISPR-Cas9 Construct to Correct Cystic Fibrosis Mutation F508del-CFTR
Creators: name: Elizabeth Morton
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Cystic fibrosis (CF) is a genetic disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene, and 90% of CF patients possess the mutation F508del-CFTR. One potential treatment for CF patients is recombinant adeno-associated virus (rAAV) gene therapy using CRISPR-Cas9 gene-editing technology. This study focused on the design and optimization of an rAAV-CRISPR-Cas9 cassette to correct F508del-mCFTR. Five CRISPR-Cas9 constructs were constructed with different sgRNA sequences (1-5). Correction efficiency of the CRISPR-Cas9 construct with sgRNA3 was tested with a dual reporter mRFP-mCFTRF508del-eGFP plasmid in HEK 293 cells. mRFP and eGFP were detected via fluorescence microscopy two days after transfection. mRFP fluorescence indicated transfection, and eGFP fluorescence indicated successful CRISPR-Cas9 editing of F508del-mCFTR. The sgRNA3 CRISPR-Cas9 construct resulted in F508del-mCFTR gene editing, as indicated by eGFP expression in combination with mRFP expression. Future research includes optimization of transfection of the dual reporter system and CRISPR-Cas9 constructs, testing of other sgRNA CRISPR-Cas9 constructs, and development of an rAAV-CRISPR-Cas9 cassette using the most efficient sgRNA CRISPR-Cas9 construct. This cassette will be tested in F508del-CFTR mouse models and has the potential to inform human gene therapy approaches.
(501492) Susanna Maria [Taunton]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Impact of Heterostructure Design on Transport Properties in the Second Landau Level of in-situ Back-Gated Two-Dimensional Electron Gases
Creators: name: Watson, J. D.
name: Csáthy, G. A.
name: Manfra, M. J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We report on transport in the second Landau level in \emph{in-situ} back-gated two-dimensional electron gases in GaAs/Al$_x$Ga$_{1-x}$As quantum wells. Minimization of gate leakage is the primary heterostructure design consideration. Leakage currents resulting in dissipation as small as $\sim$ 10 pW can cause noticeable heating of the electrons at 10 mK, limiting the formation of novel correlated states. We show that when the heterostructure design is properly optimized, gate voltages as large as 4V can be applied with negligible gate leakage, allowing the density to be tuned over a large range from depletion to over 4 $\times$ 10$^{11}$ cm$^{-2}$. As a result, the strength of the $ν= 5/2$ state can be continuously tuned from onset at n $\sim 1.2 \times 10^{11}$ cm$^{-2}$ to a maximum $Δ_{5/2} = 625$ mK at n = $3.35 \times 10^{11}$ cm$^{-2}$. An unusual evolution of the reentrant integer quantum Hall states as a function of density is also reported. These devices can be expected to be useful in experiments aimed at proving the existence of non-Abelian phases useful for topological quantum computation.
description: Re-ordered sections, added schematic of device design. 8 pages, 9 figures
Bacterial leaf scorch Xylella fastidiosa wells et al. and its potential insect vectors in pin and red oaks in central New Jersey
Creators: name: Zhang, Jianxin
Publisher: name: No Publisher Supplied
Year: 2008

description: The bacterium Xylella fastidiosa and its potential insect vectors were studied in central New Jersey. Eighteen X. fastidiosa isolates were obtained from symptomatic oaks; one isolate from the treehopper Ophiderma definita. The New Jersey X. fastidiosa strain shared high levels of nucleotide sequence identity (87-99%) with other known strains in the NCBI database. Phylogenetic analysis based on 16S-23S intergenic spacer region rRNA revealed that the New Jersey strain is X. fastidiosa subsp. multiplex closely related to isolates from oak, plum, porcelain berry, wild grape, peach, and sycamore.Xylem feeding insects were monitored in oak canopies using yellow sticky traps and fogging techniques. Thirty-seven Cicadomorpha (Order Hemiptera) insect species were collected from oak canopies. Of the 12,880 xylophages collected, 91.40% were membracids, 6.93% were cicadellids, and 1.67% were spittlebugs. More insect species and individuals were collected using fogging compared to sticky card collections. Sticky card sampling in more locations over long periods provided similar insect species numbers as fogging. Ophiderma definita comprised 68.18% of the total insects collected and peaked in early June. Sticky card collections of O. definita were male biased when females were gravid. Ophiderma definita was more abundant in pin oaks than red oaks. The sharpshooter Graphocephala versuta comprised 6.2% of the total collection and peaked in mid-July. More xylophages were collected in the asymptomatic than in symptomatic oak canopies.The X. fastidiosa DNA was detected in 21 xylophage species throughout the summer. The nucleotide sequences obtained from insects were identical to those obtained from host oaks. Fourteen percent (13.89%) of the 1618 insect specimens tested DNA positive for X. fastidiosa. Eleven percent (11.03%) of 934 membracids tested positive for X. fastidiosa: Enchenopa binota, Archasia belfragei, Cyrtolobus discoidalis, C. fenestratus, Glossonotus acuminatus, Microcentrus perditus, Ophiderma definita, Similia fasciata, Telamona extrema, T. monticola, and T. tiliae. Nineteen percent (18.79%) of 490 Cicadellidae insects tested DNA positive for X. fastidiosa: Aulacizes irrorata, G. versuta, G. coccinea, Draeculacephala anguifera, D. portola, and Oncometaopia orbona. Fifteen percent (15.08%) of 194 spittlebugs tested DNA positive for X. fastidiosa: Aphrophora quadrinotata, Clastoptera obtuse, Philaenus pallidus, and P. spumarius.
A study of the dynamics of the plasma filled rod pinch
Creators: name: MacDonald, James William
Publisher: name: Imperial College London
Year: 2019

description: The Plasma Filled Rod Pinch (PFRP) is a radiographic source used in high power flash x-ray machines. The purpose of this study is to provide detailed measurements of the plasma pre-fill required in the PFRP; then use these as a basis for 3D MHD simulations of the dynamics of the plasma in the PFRP. Several interferometry systems were developed to analyse the density of the plasma pre-fill - a fibre optic based interferometer gave information at a single point over time and a CW laser-based system giving 12 temporally and spatially resolved interferograms. Thomson scattering and spectroscopic analysis were also undertaken, enabling estimates of the electron density of the plasma in the order of 1018 /cm2 at the source with a divergence of 25 - 30°. The velocity of the plasma expansion was found to vary with the charging voltage for the system, with velocities of 8,500 – 14,500 m/s. The 12 frame interferometry system was then used to study the plasma from 6 guns placed around a central rod, a similar orientation to that used in PFRP experiments. The plasma guns were subsequently modelled as simple plasma sources, and the parameters of the plasma were set so that its behaviour matches the experimental data. The model has been used to simulate possible scenarios that could affect the performance of the PFRP. This study has provided suggestions that the snowplough phase is very resilient to variations away from the standard configuration. Future work will hopefully include simulations featuring the Hall term.
Additional file 1 of Advancing qualitative rare disease research methodology: a comparison of virtual and in-person focus group formats
Creators: name: Dwyer, Andrew A.
name: Uveges, Melissa
name: Dockray, Samantha
name: Smith, Neil
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Marine Biology
subject: Cancer
subject: Science Policy

description: Additional file 1. Focus group questions/prompts.
Host resident microbes drive accelerated proximal dysplasia and inflammation in a murine model of primary sclerosing cholangitis associated with inflammatory bowel diseases (PSC-IBD)
Creators: name: Ngo, Billy
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Background: Primary sclerosing cholangitis (PSC) is a cholestatic, fibrotic liver disease with unknown etiology. 70% patients with PSC have concomitant inflammatory bowel disease (PSC-IBD). These patients carry 3x increased risk of colorectal neoplasia that is accelerated and predominantly proximal compared to IBD alone patients. This predisposition may relate to the accumulation of bile acids from PSC, driving microbial changes in the gut that affect carcinogenesis. We previously developed a genetic murine model to study the role of microbes in PSC-IBD by crossing a model for hepatobiliary inflammation and fibrosis (mdr2-/-) with a model for spontaneous chronic colitis (il10-/-) to generate mdr2;il10 double knockout (DKO) mice. These DKO mice spontaneously developed liver and colon disease with accelerated colitis and increased neoplastic potential compared to il10-/- alone mice. In this study, we investigated the influence of the microbiota on chemically-enhanced onset of dysplasia in DKO mice by co-housing with il10-/- mice.
Hypothesis: Continuous transfer of resident microbiota from il10-/­- mice confers protection against accelerated inflammation and dysplasia in the colons of DKO mice.
Methods: Specific pathogen free 5-7 week old DKO mice were either housed with other DKO mice or cohoused with il10-/- mice. After 1 day, accelerated dysplasia was induced via azoxymethane intraperitoneal injection (10 mg/kg/week for 4 weeks). After 12 weeks, mice were sacrificed and tissue was processed for histology. Outcomes measured included weight measurements, tissue histology, and qPCR for inflammatory markers.
Results: Non-cohoused DKO mice exhibited more stunted growth and weight loss than cohoused DKO or il10-/- mice. Non-cohoused DKO mice had increased colon inflammation via histology and qPCR for TNF-α, primarily in the proximal colon compared to both cohoused DKO mice and il10-/- mice. Total dysplasia was increased in non-cohoused DKO mice compared to both cohoused groups, again primarily driven by the proximal colon. Cohousing had no obvious effect on the liver phenotype.
Conclusions: Colonic dysplasia in DKO mice was predominantly proximal and more severe than that found in il10-/- mice, similar to human PSC-iBD patients compared to IBD alone patients. It is possible that resident microbiota from il10-/- mice attenuate colon inflammation and neoplasia in DKO mice, pending microbiome analysis. These findings demonstrate the significance of the microbiome in the development of PSC-IBD and PSC-IBD-associated colorectal cancers and the potential for treatments that target the microbiome. Future work should elucidate the mechanisms underlying microbiome shifts and microbial mechanisms for colon carcinogenesis.
maerendo pauca: Lament in the Letters of Sidonius Apollinaris
Creators: name: Budd, Jennifer
Publisher: name: Macquarie University
Year: 2023
Subjects: Other education not elsewhere classified

description: This thesis explores the reasons and intentions behind the collation and publication of Sidonius Apollinaris’ letters. I examine the presence of lament within the collection and suggest that it offers a new framework for understanding his letters as a trauma narrative. I argue that Sidonius compiled his letters as an act of lament in response to traumatic events and that they function as a form of eulogy to the Western Roman Empire. In the first chapter, entitled formatio, (the act of shaping, forming, or fashioning) I address the formation of Sidonius’ letters into a collection - how and why he might have fashioned them as he did. I discuss his letters within the context of Late-Antique Epistolography, as well as the wider historical events which served as backdrop and impetus. I consider current scholarly views along with Sidonius’ stated intentions for publication and suggest a new focus for looking at his work. In Chapter 2, entitled maeror, (mourning, grief, lamentation) I present the key emotive elements within his letters alongside Classical and Christian Literature. I address this new perspective of viewing Sidonius’ letter collection through the lens of the structure of the biblical Lament Psalms. Chapter 3, entitled laudatio (commendation, praise, eulogy, panegyric) further explores the ways in which Sidonius’ letters functioned as a form of lament, but focusses on the more positive elements of praise, hope and confidence. I argue that Sidonius’ oft upbeat tone, which has been attributed to Plinian imitation, contributes to the notion of his letter collection functioning as a lament, a praise, panegyric, or eulogy to a ‘lost’ Rome.
(501494) Edith Ellen Browne
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Acute Stress Influences Decision-Making by Diminishing the Consideration of Long-Term Reward
Creators: name: Evans, Hannah
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: It is well-validated that stress impairs the ability to engage in goal-directed activity, which often enhances disadvantageous decision-making. However, the impact that this effect has on individuals’ evaluation of long-term and short-term reward is not well-understood. The current study aimed to explore how stress may enhance temporal discounting using a reinforcement learning framework, providing insight on a potential link between the two phenomena. We hypothesized that stressed individuals would have a reduction in goal-directed activity, which would enhance their tendency to choose immediately valuable but suboptimal actions. 261 participants were exposed to acute stress or the control condition before completing a novel decision-making task in which participants maximized their points over a short sequence of actions. Participants could approach this task using a suboptimal strategy that favored short-term reward or an optimal strategy that allowed for the consideration of potential future rewards through goal-directed activity. We found that participants in the stress condition made significantly more immediately valuable actions at the expense of the optimal ones than those in the control condition. These results indicate that stressed individuals engage in increased suboptimal decision-making due to the inability to consider long-term reward through goal-directed learning. Altogether, this study provides insight to a possible pathway through which goal-directed activity influences temporal discounting in a state of stress.
(501495) James Henry Browne
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Surface Optical and Bulk Acoustic Phonons in the Topological Insulator, Bi2Se2Te
Creators: name: Mukhopadhyay, Uditendu
name: Chaudhuri, Dipanjan
name: Sarkar, Jit
name: Singh, Sourabh
name: Gopal, Radha Krishna
name: Tammu, Sandeep
name: Upadhya, Prashanth C.
name: Mitra, Chiranjib
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We explore the phonon dynamics of thin films of the topological insulator material Bi2Se2Te using ultrafast pump-probe spectroscopy. The time resolved differential reflectivity of the films exhibit fast and slow oscillations. We have given a careful analysis of variation of phonon frequency as a function of film thickness attributing this to existence of standing acoustic modes. However, no variation in the frequency of the optical phonon modes was found with film thickness. This indicates that the optical phonons intrinsically belong to the surface of the topological insulators. The fact that the acoustic phonons can be tuned by changing the film thickness has tremendous potential for room temperature low power spintronic devices and in topological quantum computation.
description: 4 pages, 5 figures, 1 table
The Impact of the COVID-19 Pandemic on Asian-Identifying College Students with Disordered Eating
Creators: name: Kothari, Amoli
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: The present study investigated the effect of COVID-19 on disordered eating in Asian-American college students, and whether discrimination and social support contributed to these effects. Eligible participants (N = 42) completed an online questionnaire that collected demographic data and measured levels of discrimination experienced, social support, and disordered eating behaviors. Contrary to predictions, there was not a statistically significant correlation between COVID-19 and discrimination, COVID-19 and social support, and COVID-19 and disordered eating for this specific demographic. Additional research is needed to explore potential long-term effects of COVID-19 on disordered eating that may be seen in a longitudinal study with a larger sample.
Acceleration of ListNet for ranking using reconfigurable architecture
Creators: name: Li, Qiang
Publisher: name: Imperial College London
Year: 2019

description: Document ranking is used to order query results by relevance with ranking models. ListNet is a well-known ranking approach for constructing and training learning-to-rank models. Compared with traditional learning approaches, ListNet delivers better accuracy, but is computationally too expensive to learn models with large data sets due to the large number of permutations and documents involved in computing the gradients. Currently, the long training time limits the practicality of ListNet in ranking applications such as breaking news search and stock prediction, and this situation is getting worse with the increase in data-set size. In order to tackle the challenge of long training time, this thesis optimises the ListNet algorithm, and designs hardware accelerators for learning the ListNet algorithm using Field Programmable Gate Arrays (FPGAs), making the algorithm more practical for real-world application. The contributions of this thesis include: 1) A novel computation method of the ListNet algorithm for ranking. The proposed computation method exposes more fine-grained parallelism for FPGA implementation. 2) A weighted sampling method that takes into account the ranking positions, along with an effective quantisation method based on FPGA devices. The proposed design achieves a 4.42x improvement over GPU implementation speed, while still guaranteeing the accuracy. 3) A full reconfigurable architecture for the ListNet training using multiple bitstream kernels. The proposed method achieves a higher model accuracy than pure fixed point training, and a better throughput than pure floating point training. This thesis has resulted in the acceleration of the ListNet algorithm for ranking using FPGAs by applying the above techniques. Significant improvements in speed have been achieved in this work against CPU and GPU implementations.
Additional file 2 of Advancing qualitative rare disease research methodology: a comparison of virtual and in-person focus group formats
Creators: name: Dwyer, Andrew A.
name: Uveges, Melissa
name: Dockray, Samantha
name: Smith, Neil
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Marine Biology
subject: Cancer
subject: Science Policy

description: Additional file 2. Presence of themes and sub-themes by focus group.
Gratitude as a Moderator for the Relation Between Relationship Quality and Social- Emotional Competence in Opportunity Youth
Creators: name: Alegria, Juliet
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: 
Previous research has investigated the positive outcomes associated with having strong relationships and the additional benefits of experiencing gratitude, but little research has been conducted on whether they relate to social-emotional competence. Opportunity youth, youth aged 15-26 at-risk or experiencing homelessness and accessing services, may benefit from higher levels of social-emotional competence to bolster their ability to communicate with others and access resources, but they tend to experience a lack of support. The current study examines the relationship between relationship quality and social-emotional competence as well as this relation with the addition of gratitude as a moderator with a sample of opportunity youth (n = 35). Data was collected from a self-report survey and linear regressions were conducted with the responses. Results indicated (1) a significant relation between relationship quality and social- emotional competence, (2) but gratitude did not moderate this relation. These results have important implications for developing helpful programming for vulnerable youth as well as future directions of research.
Source apportionment and measurement of PCBs and POPs in NY/NJ area
Creators: name: Du, Songyan
Publisher: name: No Publisher Supplied
Year: 2009

description: Investigating the source of Persistent Organic Pollutants (Dachs et al. ) in ambient air and water is imperative in the development and implementation of Total Maximum Daily Load (TMDL) process for the impaired water bodies. Atmospheric deposition is an important process involved in the TMDL modeling, therefore one objective of this thesis aims to achieve is how to identify PCB source types and regions in air. The coupling of Positive matrix factorization (PMF) model, which is use to apportion the contributing sources, with potential source contribution function (PSCF) model, which is used to locate the source regions, allowed the identification of PCB sources in urban air in Camden, US. Four factors are identified which are thought to represent sources such as volatilized Aroclors and particle-phase PCBs. The PSCF model output for ΣPCBs and the resolved factors suggests that the urban PCB signal is comprised of multiple signals, some of which may come from discrete sources that can be identified and remediated.As an attempt to refine the atmospheric deposition modeling input, passive sampling study is conducted to investigate the spatial extent of the urban-impacted elevated atmospheric persistent organic pollutants (POPs) including PCBs, PAHs, OCPs and BDEs by deploying passive samplers at 32 sites across the Philadelphia-Camden area. This study revealed two maxima for PCBs representative of urban (population density driven) sources vs. industrial sources, highlighting the potential role of densely populated urban centers as well as industrial areas as sources of PCBs to the regional environment. PAHs and BDEs all showed urban-rural gradients with maximum concentrations found in the urban center. Some of OCPs showed urban-rural gradient, while others exhibited either a relatively uniform concentration level across the sampling area or a relatively random spatial distribution. In order to corroborate the loading estimate used in the development of TMDL, PMF model is also used to apportion the source of PCBs in Delaware River and NY/NJ Harbor Estuary. The analysis of ambient water either generally corroborates the PCB loading estimate used in the water quality model or identified factors associated with top loading categories in previous mass balance study.
The Role of In Vivo Exposure to Inorganic Arsenic and Folate Intake on Gene Expression in Humanized C57BL/6 Sperm Cells
Creators: name: Grmani, Ahmed
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Arsenic is a naturally occurring element found in water sources, foods, soil, and air. However, arsenic is considered a human carcinogen, specifically in its inorganic form(s), due to its strong links to several illnesses. Inorganic arsenic (iAs) is mainly metabolized in the liver to methylated metabolites. Arsenic methylation is dependent on SAM presence in the body. AS3MT is a hepatic enzyme that is responsible for catalyzing the methyl group transfer from SAM to iAs to produce MA and subsequently DMA. This study aims to explore the role that folate plays in the arsenic methylation process, specifically in sperm cells. The overall goal is to understand whether altering folate intake impacts arsenic metabolism as well as determining which genes are upregulated and downregulated based on exposure group. I hypothesized that altering folate intake will impact arsenic metabolism as well as gene expression in the humanized (Hu) mice. Our results show that folate intake does affect gene expression in humanized sperm cells, with similar effects between the folate adequate and folate supplemented groups in certain annotated pathways.
Candidates for Long Lived High-K Ground States in Superheavy Nuclei
Creators: name: Jachimowicz, P.
name: Kowal, M.
name: Skalski, J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: On the basis of systematic calculations for 1364 heavy and superheavy nuclei, including odd-systems, we have found a few candidates for high-K ground states in superheavy nuclei. The macroscopic-microscopic model based on the deformed Woods-Saxon single particle potential which we use offers a reasonable description of SH systems, including known: nuclear masses, $Q_α$-values, fission barriers, ground state deformations, super- and hyper-deformed minima in the heaviest nuclei. %For odd and odd-odd systems, both ways of including pairing correlations, % blocking and the quasi-particle method, have been applied. Exceptionally untypical high-K intruder contents of the g.s. found for some nuclei accompanied by a sizable excitation of the parent configuration in daughter suggest a dramatic hindrance of the $α$-decay. Multidimensional hyper-cube configuration - constrained calculations of the Potential Energy Surfaces (PES's) for one especially promising candidate, $^{272}$ Mt, shows a $\backsimeq$ 6 MeV increase in the fission barrier above the configuration- unconstrained barrier. There is a possibility, that one such high-K ground- or low-lying state may be the longest lived superheavy isotope.
description: Accepted in PRC
(501487) Mary Adela Taunton
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
THE USE OF ANDROID-BASED MOBILE LEARNING APPLICATION TO COMPREHEND LOCAL-BASED DESCRIPTIVE TEXT
Creators: name: Sumanti, Dewi
name: Asi, Natalina
name: Bungai, Joni
Publisher: name: Zenodo
Year: 2020

description: This is about THE USE OF ANDROID-BASED MOBILE LEARNING APPLICATION TO COMPREHEND LOCAL-BASED DESCRIPTIVE TEXT
Additional file 1 of Real-world evidence of biologic treatments in psoriatic arthritis in Italy: results of the CHRONOS (EffeCtiveness of biologic treatments for psoriatic artHRitis in Italy: an ObservatioNal lOngitudinal Study of real-life clinical practice) observational longitudinal study
Creators: name: Colombo, Delia
name: Frassi, Micol
name: Pagano Mariano, Giusy
name: Fusaro, Enrico
name: Lomater, Claudia
name: Del Medico, Patrizia
name: Iannone, Florenzo
name: Foti, Rosario
name: Limonta, Massimiliano
name: Marchesoni, Antonio
name: Raffeiner, Bernd
name: Viapiana, Ombretta
name: Grassi, Walter
name: Grembiale, Rosa Daniela
name: Guggino, Giuliana
name: Mazzone, Antonino
name: Tirri, Enrico
name: Perricone, Roberto
name: Sarzi Puttini, Pier Carlo
name: De Vita, Salvatore
name: Conti, Fabrizio
name: Ori, Alessandra
name: Simoni, Lucia
name: Fiocchi, Martina
name: Orsenigo, Roberto
name: Zagni, Emanuela
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Socio-demographic and clinical characteristics at enrollment/start of biologic treatment under analysis (in Secukinumab and TNFis patients). In this file main socio-demographic and clinical characteristics at enrollment/start of biologic treatment under analysis are described in the groups of patients treated with Secukinumab and with TNFis.
(501491) George Edwin Taunton
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Impacts of supersymmetric higher derivative terms on inflation models in supergravity
Creators: name: Aoki, Shuntaro
name: Yamada, Yusuke
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We show the effects of supersymmetric higher derivative terms on inflation models in supergravity. The results show that such terms generically modify the effective kinetic coefficient of the inflaton during inflation if the cut off scale of the higher derivative operators is sufficiently small. In such a case, the $η$-problem in supergravity does not occur, and we find that the effective potential of the inflaton generically becomes a power type potential with a power smaller than two.
description: 16 pages, v2: references and comments added, some typos corrected
Additional file 1 of Single nucleotide polymorphism genes and mitochondrial DNA haplogroups as biomarkers for early prediction of knee osteoarthritis structural progressors: use of supervised machine learning classifiers
Creators: name: Bonakdari, Hossein
name: Pelletier, Jean-Pierre
name: Blanco, Francisco J.
name: Rego-Pérez, Ignacio
name: Durán-Sotuela, Alejandro
name: Aitken, Dawn
name: Jones, Graeme
name: Cicuttini, Flavia
name: Jamshidi, Afshin
name: Abram, François
name: Martel-Pelletier, Johanne
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Additional file 1: Fig. S1. Frequency of single nucleotide polymorphism (SNP) genes in the studied population (n=901). We performed a dominant model of the risk alleles for the 8 SNPs: rs12107036.TP63, rs4730250. DUS4L, rs10948172.SUPT3H, rs11842874.MCF2L, rs8044769.FTO, rs11177.GNL3, rs143383.GDF5, rs3771501.TGFA. The column indicates the frequency for all the population. No, absence of the allele; NP, the number of no-progressors; P, the number of progressors; Yes, presence of the allele. Progressors and no-progressors are defined in the Methods section.
Low-dimensional representations of neural time-series data with applications to peripheral nerve decoding
Creators: name: Lubba, Carl Henning Thore
Publisher: name: Imperial College London
Year: 2020

description: Bioelectronic medicines, implanted devices that influence physiological states by peripheral neuromodulation, have promise as a new way of treating diverse conditions from rheumatism to diabetes. We here explore ways of creating nerve-based feedback for the implanted systems to act in a dynamically adapting closed loop. In a first empirical component, we carried out decoding studies on in vivo recordings of cat and rat bladder afferents. In a low-resolution data-set, we selected informative frequency bands of the neural activity using information theory to then relate to bladder pressure. In a second high-resolution dataset, we analysed the population code for bladder pressure, again using information theory, and proposed an informed decoding approach that promises enhanced robustness and automatic re-calibration by creating a low-dimensional population vector. Coming from a different direction of more general time-series analysis, we embedded a set of peripheral nerve recordings in a space of main firing characteristics by dimensionality reduction in a high-dimensional feature-space and automatically proposed single efficiently implementable estimators for each identified characteristic. For bioelectronic medicines, this feature-based pre-processing method enables an online signal characterisation of low-resolution data where spike sorting is impossible but simple power-measures discard informative structure. Analyses were based on surrogate data from a self-developed and flexibly adaptable computer model that we made publicly available. The wider utility of two feature-based analysis methods developed in this work was demonstrated on a variety of datasets from across science and industry. (1) Our feature-based generation of interpretable low-dimensional embeddings for unknown time-series datasets answers a need for simplifying and harvesting the growing body of sequential data that characterises modern science. (2) We propose an additional, supervised pipeline to tailor feature subsets to collections of classification problems. On a literature standard library of time-series classification tasks, we distilled 22 generically useful estimators and made them easily accessible.
(501493) James William Browne
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.