cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Detection and characterisation of heat shock responses in relation to cell death signaling in human cancer cells
Creators: name: Lavanya Ramapathiran
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Defects in apoptosis are one of the major causes of cancer. Several therapies have been developed to treat cancers such as chemotherapy, irradiation and hyperthermia. In the first part of this study an investigation of the underlying mechanism of lethal hyperthermia was undertaken in HeLa cervical cancer cells. A lethal heat shock activated the JNK pathway and increased p53, Puma, Bim, Mcl-I and Hsp70 expression. Caspase-3 was also activated but analysis of caspase- 2, caspase-8 and Bid cleavage showed little activation of these proteins making their requirement unclear. More importantly a robust Hsp70 induction was observed upon lethal hyperthermia which repressed amplified JNK phosphorylation and Bim expression. Interestingly inhibition of Hsp7O resulted in activation of Foxo3a, another protein involved in apoptosis. High levels of Hsp70 have been detected in several cancers and is involved in the resistance to anti-cancer treatments. Inhibition of the proteasome is another strategy used in cancer therapies but also results in Hsp70 up-regulation. We designed a reporter plasmid that mimics Hsp70 expression using the EGFP as a fluorescent probe. Studies investigating the stress dependent transcriptional expression of Hsp70 upon proteasome inhibition using epoxomicin were conducted in HCT 116 colon cancer cells at the single cell level using epifluorescent microscopy and High Content Screening. Increases in Hsp70 levels were evident in a stress dependent manner. Survival of cells upon proteasome inhibition was related to the amount of inducible Hsp70 accumulated which was dependent on two factors; the rate at which Hsp70 synthesis occurred and the length of activation of the Hsp70 promoter. Hsp70 basal expression and the onset time of its synthesis did not contribute to cell protection.
Functional studies of microRNAs involved with ATRA induced differentiation of neuroblastoma cells
Creators: name: Foley, Niamh
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: MicroRNA dysregulation has been widely reported in many cancers, including neuroblastoma, an often fatal paediatric cancer originating from precursor cells of the sympathetic nervous system. MiRNAs function as negative regulators of post-transcriptional gene expression, and can have oncogenic or tumour suppressor functions. Here, we describe a large number of miRNAs that have altered expression in All-Trans Retinoic Acid (ATRA) induced differentiation of neuroblastoma cell lines. Differentiation status is associated with good prognosis in neuroblastoma, suggesting these ATRA-sensitive miRNAs play an essential mechanistic role in neuroblastoma pathogenesis. The aim of our study was to elucidate the functional role of ATRA-sensitive miRNAs, and their contribution to neuroblastoma outcome and disease. Forced over or under-expression of miR- 184, miR- 1 Oa, miR- 1 Ob, miR- 152 and miR-196a was accomplished in a variety of neuroblastoma cell lines, allowing us to determine the biological effects of each individual miRNA. The phenotypic effects included mo~-phological differentiation, increased apoptosis, decreased cell proliferation, invasiveness, anchorage-independent cell growth, along with alterations in DNA methylation patterns and profound changes in rnRNA transcript levels. mRNA targets were identified for miR-184 (AKT2), miR-10 (NCOR2) and miR-152 (DNMTI), allowing us to further define the mechanism by which each miRNA alters the cellular phenotype. In conclusion, this study describes a detailed functional analysis of five ATRA-induced miRNAs. We identified rniRNAs that play functional roles in apoptosis, DNA methylation and differentiation in neuroblastoma cancer cells and demonstrated the relevance of these miRNAs to clinical parameters in neuroblastoma primary tumours. It is also proposed that these miRNAs could be of some value in potential rniRNA-mediated therapeutics given their anti-proliferative effects on cells in vitro.
Sample size for a non-inferiority clinical trial with time-to-event data in the presence of competing risks
Creators: name: Han, Dong
name: Chen, Zheng
name: Hou, Yawen
Publisher: name: arXiv
Year: 2018
Subjects: subject: Applications (stat.AP)
subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: The analysis and planning methods for competing risks model have been described in the literatures in recent decades, and non-inferiority clinical trials are helpful in current pharmaceutical practice. Analytical methods for non-inferiority clinical trials in the presence of competing risks were investigated by Parpia et al., who indicated that the proportional sub-distribution hazard model is appropriate in the context of biological studies. However, the analytical methods of competing risks model differ from those appropriate for analyzing non-inferiority clinical trials with a single outcome; thus, a corresponding method for planning such trials is necessary. A sample size formula for non-inferiority clinical trials in the presence of competing risks based on the proportional sub-distribution hazard model is presented in this paper. The primary endpoint relies on the sub-distribution hazard ratio. A total of 120 simulations and an example based on a randomized controlled trial verified the empirical performance of the presented formula. The results demonstrate that the empirical power of sample size formulas based on the Weibull distribution for non-inferiority clinical trials with competing risks can reach the targeted power.
description: 24 pages, 1 figure
title: ADCO, Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.2 (2e moitié XIIIe siècle), Cart. 167 (11 H 67), f. 0055v
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2010
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.2 (2e moitié XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 167 (11 H 67), f. 0055v, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.2 (2e moitié XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 167 (11 H 67), f. 0055v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Horizontal Dehn Surgery and genericity in the curve complex
Creators: name: Lustig, Martin
name: Moriah, Yoav
Publisher: name: arXiv
Year: 2007
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 57M99

description: We introduce a general notion of "genericity" for countable subsets of a space with Borel measure, and apply it to the set of vertices in the curve complex of a surface S, interpreted as subset of the space of projective measured laminations in S, equipped with its natural Lebesgue measure. We prove that, for any 3-manifold M, the set of curves c on a Heegaard surface S in M, such that every non-trivial Dehn twist at c yields a Heegaard splitting of high distance, is generic in the set of all essential simple closed curves on S. Our definition of "genericity" is different and more intrinsic than alternative such existing notions, given e.g. via random walks or via limits of quotients of finite sets.
description: This version contains a substantially stronger version of the main theorem. 31 pages 4 figures
Live Multi-language Development and Runtime Environments
Creators: name: Niephaus, Fabio
name: Felgentreff, Tim
name: Pape, Tobias
name: Hirschfeld, Robert
name: Taeumel, Marcel
Publisher: name: arXiv
Year: 2018
Subjects: subject: Programming Languages (cs.PL)
subject: FOS: Computer and information sciences

description: Context: Software development tools should work and behave consistently across different programming languages, so that developers do not have to familiarize themselves with new tooling for new languages. Also, being able to combine multiple programming languages in a program increases reusability, as developers do not have to recreate software frameworks and libraries in the language they develop in and can reuse existing software instead. Inquiry: However, developers often have a broad choice of tools, some of which are designed for only one specific programming language. Various Integrated Development Environments have support for multiple languages, but are usually unable to provide a consistent programming experience due to different language-specific runtime features. With regard to language integrations, common mechanisms usually use abstraction layers, such as the operating system or a network connection, which are often boundaries for tools and hence negatively affect the programming experience. Approach: In this paper, we present a novel approach for tool reuse that aims to improve the experience with regard to working with multiple high-level dynamic, object-oriented programming languages. As part of this, we build a multi-language virtual execution environment and reuse Smalltalk's live programming tools for other languages. Knowledge: An important part of our approach is to retrofit and align runtime capabilities for different languages as it is a requirement for providing consistent tools. Furthermore, it provides convenient means to reuse and even mix software libraries and frameworks written in different languages without breaking tool support. Grounding: The prototype system Squimera is an implementation of our approach and demonstrates that it is possible to reuse both development tools from a live programming system to improve the development experience as well as software artifacts from different languages to increase productivity. Importance: In the domain of polyglot programming systems, most research has focused on the integration of different languages and corresponding performance optimizations. Our work, on the other hand, focuses on tooling and the overall programming experience.
title: UMass ADVANCE STEM Rank and Gender Findings 2022
Creators: name: Liu, Shuyin
name: Misra, Joya
name: Smith-Doerr, Laurel
Publisher: name: University of Massachusetts Amherst
Year: 2023

description: In this research brief, we describe some of the key findings from this survey, focusing on patterns among STEM faculty by gender and rank. We explore whether and how the intersection of gender and rank affect STEM faculty inclusion, shared decision-making, and research collaboration.
Smoothed Particle Interpolation
Creators: name: Laguna, Pablo
Publisher: name: arXiv
Year: 1994
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Smoothed particle hydrodynamics (SPH) discretization techniques are generalized to develop a method, smoothed particle interpolation (SPI), for solving initial value problems of systems of non-hydrodynamical nature. Under this approach, SPH is viewed as strictly an interpolation scheme and, as such, suitable for solving general hyperbolic and parabolic equations. The SPI method is tested on (1) the wave equation with inhomogeneous sound speed and (2) Burgers equation. The efficiency of SPI is studied by comparing SPI solutions to those obtained with standard finite difference methods. It is shown that the power of SPI arises when the smoothing particles are free to move.
description: 13 pages (LaTeX), 9 figures (not included), pablo@astro.psu.edu
title: PROOF THAT EINSTEIN WAS NOT WRONG AND THAT FINALLY HE WINS THE DISCUSSION VS JOHN BELL
title: Einstein vs. Bell: The Quantum Debate on Non-locality
titleType: Subtitle
Creators: name: Sandoval Rodríguez, Alfredo José
Publisher: name: Zenodo
Year: 2025

description: Historically, a significant dispute emerged between Albert Einstein and John Bell concerning the acceptance of nonlocal correlations in quantum mechanics. Einstein's landmark work, co-authored with Boris Podolsky and Nathan Rosen, led to the development of the EPR paradox, which raised doubts about the completeness of quantum mechanics. Einstein's seminal work, in collaboration with his colleagues Boris Podolsky and Nathan Rosen, laid the groundwork for the EPR paradox, which planted a seed of doubt that quantum mechanics might be incomplete.  This paradox subsequently served as the catalyst for John Bell's formulation of Bell's inequality, which provided a mathematical framework suggesting the existence of nonlocal correlations—correlations that could not be accounted for by local hidden variables—and contributed to his development of the theory of superposition.  He rejected this assertion, defending his position with arguments such as the "ghostly effect and that "the moon exists" in the latter, attempting to preserve the principles of locality and realism.

 

I intend to demonstrate that Albert Einstein’s stance is correct and he is the winner of this debate, proving that correlations can be explained by hidden variables.
The Role of Anaerobic Bacteria in Cystic Fibrosis Lung Disease.
Creators: name: Murray, Michelle
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Recurrent bacterial infections in Cystic Fibrosis (CF) are the primary cause for morbidity and mortality in CF. Advancements in second generation sequencing and evolution of the lung microbiome has prompted greater interest in other bacteria present in the lung. Anaerobic bacteria have been one of the most common bacteria found on molecular sequencing, their cause and role is as of yet unknown. In our project, we recruited 450 patients prospectively and followed them at both stable and exacerbation timepoints. Their sputum and BAL was cultured and sequenced from both adults and children. The most prevalent bacteria found, Prevotella me/aninogenicawas found to produce proteases that inhibited naturally occurring defensins and anti-microbial peptides and the short chain acids produced by these bacteria were shown to have a pro-inflammatory effect. This provides evidence that certain anaerobic bacteria are pathogenic and these bacteria should be more directly targeted against during an exacerbation.
Exact Superstring Motivated Cosmological Models
Creators: name: Easther, Richard
Publisher: name: arXiv
Year: 1993
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present a number of new, exact scalar field cosmologies where the potential consists of two or more exponential terms. Such potentials are motivated by supergravity or superstring models formulated in higher dimensional spacetimes that have been compactified to (3+1)-dimensions. We have found solutions in both curved and flat Robertson Walker spacetimes. These models have a diverse range of properties and often possess several distinct phases, with a smooth transition between ordinary and inflationary expansion. While exponential potentials typically produce powerlaw inflation, we find models where the inflationary period contains eras of both powerlaw and exponential growth.
description: 18 pages (includes 2 uuencoded postscript figures), NZ-CAN-RE-93/2
title: ADCO, Septième cartulaire de Saint-Étienne de Dijon (1661-1665), Cart. 29 (G 134), 996 folios, f. 0519
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Septième cartulaire de Saint-Étienne de Dijon (1661-1665), Archives départementales de la Côte-d'Or, Cart. 29 (G 134), 996 folios, f. 0519, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Septième cartulaire de Saint-Étienne de Dijon (1661-1665), Archives départementales de la Côte-d'Or, Cart. 29 (G 134), 996 folios, f. 0519, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
On the Finite Temperature Effective Potential in Scalar QED with N Flavors
Creators: name: Carena, M.
name: Wagner, C. E. M.
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The effective potential of scalar quantum electrodynamics with N flavors of complex scalar fields is studied, by performing a self consistent 1/N expansion up to next to leading order in $1/N$. Starting from the broken phase at zero temperature, the theory exhibits a phase transition to the symmetric phase at some finite temperature $T_c$. We work in general covariant gauges and demonstrate the gauge invariance of both, the critical temperature $T_c$ and the minimization condition at any finite temperature T. Furthermore, the only minimum of the potential is at zero scalar vacuum expectation value for any temperature $T \geq T_c$ and varies continuously to nonzero values for temperatures below $T_c$, implying the existence of a second order phase transition.
description: 33 pages and 2 figures (available upon request), MPI-Ph/92-67, August 1992
KMT-2016-BLG-0212: First KMTNet-Only Discovery of a Substellar Companion
Creators: name: Hwang, K. -H.
name: Kim, H. -W.
name: Kim, D. -J.
name: Gould, A.
name: Albrow, M. D.
name: Chung, S. -J.
name: Han, C.
name: Jung, Y. K.
name: Ryu, Y. -H.
name: Shin, I. -G.
name: Shvartzvald, Y.
name: Yee, J. C.
name: Zang, W.
name: Zhu, W.
name: Cha, S. -M.
name: Kim, S. -L.
name: Lee, C. -U.
name: Lee, D. -J.
name: Lee, Y.
name: Park, B. -G.
name: Pogge, R. W.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We present the analysis of KMT-2016-BLG-0212, a low flux-variation $(I_{\rm flux-var}\sim 20$) microlensing event, which is well-covered by high-cadence data from the three Korea Microlensing Telescope Network (KMTNet) telescopes. The event shows a short anomaly that is incompletely covered due to the brief visibility intervals that characterize the early microlensing season when the anomaly occurred. We show that the data are consistent with two classes of solutions, characterized respectively by low-mass brown-dwarf $(q=0.037)$ and sub-Neptune $(q<10^{-4})$ companions, respectively. Future high-resolution imaging should easily distinguish between these solutions.
description: 9 pages, 8 figures
Additional file 1: of Novel metrics for quantifying bacterial genome composition skews
Creators: name: Joesch-Cohen, Lena
name: Robinson, Max
name: Jabbari, Neda
name: Lausted, Christopher
name: Glusman, Gustavo
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Hematology

description: Supplementary figures. (DOCX 1778 kb)
Evaluating Moodle In Undergraduate Obstetrics and Gynaecology.
Creators: name: McVey, Ruaidhri M.
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: ‘Medical education is a national strategic asset that reflects well on the country, attracts the brightest and best school leavers from home and abroad and caters for our health needs. We have not, alas, looked after medical education in a manner that allows us to reassure the public that all is well.’ Irish Medical Council, 2003 In 1989, Tim Berners-Lee invented the World Wide Web, and within 10 years it had become a valuable learning resource for the field of medicine. With the aim of improving the undergraduate student experience, educators have experimented with a variety of information technologies for the delivery of medical education. Web 2.0 is helping students to ascertain their learning goals effectively. Little evidence is available for the implementation of Moodle, a virtual learning environment, into an undergraduate obstetrics and gynaecology curriculum. This thesis demonstrates the integration of Moodle into the course, and the added value as it developed. Moodle was used to deliver a comprehensive online undergraduate curriculum in obstetrics and gynecology, in a multi-site Irish medical school setting in order to optimize clinical exposure for students. There is a paucity of evidence on reliably identifying medical students who are academically underperforming prior to high stakes examinations. Moodle has consistently demonstrated the ability to identify these struggling students This body of work informs and empowers educators and students to develop their teaching and learning. This thesis provides a point from which future work may examine the learning styles and behaviors of underperforming students with a view to effective remediation. The implementation and evaluation of Moodle was deemed not to require formal Ethics Board approval.
Fast, Flexible, Polyglot Instrumentation Support for Debuggers and other Tools
Creators: name: Van De Vanter, Michael
name: Seaton, Chris
name: Haupt, Michael
name: Humer, Christian
name: Würthinger, Thomas
Publisher: name: arXiv
Year: 2018
Subjects: subject: Programming Languages (cs.PL)
subject: FOS: Computer and information sciences

description: Context: Software development tools that interact with running programs such as debuggers, profilers, and dynamic analysis frameworks are presumed to demand difficult tradeoffs among implementation complexity (cost), functionality, usability, and performance. Among the many consequences, tools are often delivered late (if ever), have limited functionality, require non-standard configurations, and impose serious performance costs on running programs. Inquiry: Can flexible tool support become a practical, first class, intrinsic requirement for a modern highperformance programming language implementation framework? Approach: We extended the Truffle Language Implementation Framework, which together with the GraalVM execution environment makes possible very high performance language implementations. Truffle's new Instrumentation Framework is language-agnostic and designed to derive high performance from the same technologies as do language implementations. Truffle Instrumentation includes: (1) low overhead capture of execution events by dynamically adding "wrapper" nodes to executing ASTs; (2) extensions to the Language Implementation Framework that allow per-language specialization, primarily for visual display of values and names, among others; and (3) versatile APIs and support services for implementing many kinds of tools without VM modification. Knowledge: It is now possible for a client in a production environment to insert (dynamically, with thread safety) an instrumentation probe that captures and reports abstractly specified execution events. A probe in fully optimized code imposes very low overhead until actually used to access (or modify) execution state. Event capture has enabled construction of numerous GraalVM services and tools that work for all implemented languages, either singly or in combination. Instrumentation has also proved valuable for implementing some traditionally tricky language features, as well as some GraalVM services such as placing bounds on resources consumed by running programs. Grounding: Tools for debugging (via multiple clients), profiling, statement counting, dynamic analysis, and others are now part of GraalVM or are in active development. Third parties have also used Truffle Instrumentation for innovative tool implementations. Importance: Experience with Truffle Instrumentation validates the notion that addressing developer tools support as a forethought can change expectations about the availability of practical, efficient tools for high-performance languages. Tool development becomes a natural part of language implementation, requiring little additional effort and offering the advantage of early and continuous availability.
Additional file 13: of Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control
Creators: name: MartĂ­Nez-Lumbreras, Santiago
name: Krysztofinska, Ewelina
name: Thapaliya, Arjun
name: Spilotros, Alessandro
name: Matak-Vinkovic, Dijana
name: Salvadori, Enrico
name: Roboti, Peristera
name: Nyathi, Yvonne
name: Muench, Janina
name: Roessler, Maxie
name: Svergun, Dmitri
name: High, Stephen
name: Isaacson, Rivka
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Figure S12. Selected mutations in the TPR domain for MTSL labelling in the EPR experiments. (A) Cartoon representation of the TPR domain with the four positions depicted as green balls. (B) Surface representation of the TPR domain with the four residues colored in green. Notice that the S136C mutation is inside the TPR groove. (PDF 129 kb)
Repeated multi-qubit readout and feedback with a mixed-species trapped-ion register
Creators: name: Negnevitsky, Vlad
name: Marinelli, Matteo
name: Mehta, Karan
name: Lo, Hsiang-Yu
name: Flühmann, Christa
name: Home, Jonathan P.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Physics (quant-ph)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: Quantum error correction will be essential for realizing the full potential of large-scale quantum information processing devices. Fundamental to its experimental realization is the repetitive detection of errors via projective measurements of quantum correlations among qubits, and correction using conditional feedback. Performing these tasks repeatedly requires a system in which measurement and feedback decision times are short compared to qubit coherence times, where the measurement reproduces faithfully the desired projection, and for which the measurement process has no detrimental effect on the ability to perform further operations. Here we demonstrate up to 50 sequential measurements of correlations between two beryllium-ion qubits using a calcium ion ancilla, and implement feedback which allows us to stabilize two-qubit subspaces as well as Bell states. Multi-qubit mixed-species gates are used to transfer information from qubits to the ancilla, enabling quantum state detection with negligible crosstalk to the stored qubits. Heating of the ion motion during detection is mitigated using sympathetic recooling. A key element of the experimental system is a powerful classical control system, which features flexible in-sequence processing to implement feedback control. The methods employed here provide a number of essential ingredients for scaling trapped-ion quantum computing, and provide new opportunities for quantum state control and entanglement-enhanced quantum metrology.
description: 9 pages including methods, 6 figures; v2: typos and minor edits
Coulomb-bound four- and five-particle valleytronic states in an atomically-thin semiconductor
Creators: name: Chen, Shao-Yu
name: Goldstein, Thomas
name: Taniguchi, Takashi
name: Watanabe, Kenji
name: Yan, Jun
Publisher: name: arXiv
Year: 2018
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: As hosts for tightly-bound electron-hole pairs carrying quantized angular momentum, atomically-thin semiconductors of transition metal dichalcogenides provide an appealing platform for optically addressing the valley degree of freedom. In particular, the valleytronic properties of neutral and charged excitons in these systems have been widely investigated. Meanwhile, correlated quantum states involving more particles are so far elusive and controversial. Here we present experimental evidence for valleytronic four-particle biexcitons and five-particle exciton-trions in high-quality monolayer tungsten diselenide samples. Through charge doping, thermal activation, and magnetic-field tuning measurements, we determined that the biexciton and exciton-trion optical emissions are bound with respect to the bright exciton and the trion respectively. Further, both the biexciton and the exciton-trion are intervalley bound states involving dark excitons, giving rise to emissions with large, negative valley polarizations in contrast to that of the well-known two-particle excitons. Our studies provide new opportunities for building valleytronic quantum devices harnessing high-order excitations.
title: ADCO, Comptes du Petit-Cîteaux (1477-1491) (11 H 1179), f. 00280
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: comptes

description: Comptes du Petit-Cîteaux (1477-1491), Archives départementales de la Côte-d'Or, (11 H 1179). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Comptes du Petit-Cîteaux (1477-1491), Archives départementales de la Côte-d'Or, (11 H 1179), f. 00280, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Consistency and application of moving block bootstrap for non-stationary time series with periodic and almost periodic structure
Creators: name: Synowiecki, Rafal
Publisher: name: arXiv
Year: 2007
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics

description: The aim of this paper it to establish sufficient conditions for consistency of moving block bootstrap for non-stationary time series with periodic and almost periodic structure. The parameter of the study is the mean value of the expectation function. Consistency holds in quite general situations: if all joint distributions of the series are periodic, then it suffices to assume the central limit theorem and strong mixing property, together with summability of the autocovariance function. In the case where the mean function is almost periodic, we additionally need uniform boundedness of the fourth moments of the root statistics. It is shown that these theoretical results can be applied in statistical inference concerning the Fourier coefficients of periodically (PC) and almost periodically (APC) correlated time series. A simulation example shows how to use a graphical diagnostic test for significant frequencies and stationarity within these classes of time series.
description: Published in at http://dx.doi.org/10.3150/07-BEJ102 the Bernoulli (http://isi.cbs.nl/bernoulli/) by the International Statistical Institute/Bernoulli Society (http://isi.cbs.nl/BS/bshome.htm)
Language-integrated provenance in Haskell
Creators: name: Stolarek, Jan
name: Cheney, James
Publisher: name: arXiv
Year: 2018
Subjects: subject: Programming Languages (cs.PL)
subject: FOS: Computer and information sciences

description: Scientific progress increasingly depends on data management, particularly to clean and curate data so that it can be systematically analyzed and reused. A wealth of techniques for managing and curating data (and its provenance) have been proposed, largely in the database community. In particular, a number of influential papers have proposed collecting provenance information explaining where a piece of data was copied from, or what other records were used to derive it. Most of these techniques, however, exist only as research prototypes and are not available in mainstream database systems. This means scientists must either implement such techniques themselves or (all too often) go without. This is essentially a code reuse problem: provenance techniques currently cannot be implemented reusably, only as ad hoc, usually unmaintained extensions to standard databases. An alternative, relatively unexplored approach is to support such techniques at a higher abstraction level, using metaprogramming or reflection techniques. Can advanced programming techniques make it easier to transfer provenance research results into practice? We build on a recent approach called language-integrated provenance, which extends language-integrated query techniques with source-to-source query translations that record provenance. In previous work, a proof of concept was developed in a research programming language called Links, which supports sophisticated Web and database programming. In this paper, we show how to adapt this approach to work in Haskell building on top of the Database-Supported Haskell (DSH) library. Even though it seemed clear in principle that Haskell's rich programming features ought to be sufficient, implementing language-integrated provenance in Haskell required overcoming a number of technical challenges due to interactions between these capabilities. Our implementation serves as a proof of concept showing how this combination of metaprogramming features can, for the first time, make data provenance facilities available to programmers as a library in a widely-used, general-purpose language. In our work we were successful in implementing forms of provenance known as where-provenance and lineage. We have tested our implementation using a simple database and query set and established that the resulting queries are executed correctly on the database. Our implementation is publicly available on GitHub. Our work makes provenance tracking available to users of DSH at little cost. Although Haskell is not widely used for scientific database development, our work suggests which languages features are necessary to support provenance as library. We also highlight how combining Haskell's advanced type programming features can lead to unexpected complications, which may motivate further research into type system expressiveness.
Additional file 1 of Mixture toxic impacts and the related mechanism of aflatoxin B1 and deoxynivalenol on embryonic zebrafish (Danio rerio)
Creators: name: Wang, Yanhua
name: Wang, Qiang
name: Ji, Chun
name: Guo, Xiaoxuan
name: Yang, Guiling
name: Wang, Dou
name: Weng, Hongbiao
name: Qian, Yongzhong
name: Chen, Chen
Publisher: name: figshare
Year: 2021
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Additional file 1: Table S1. Gene primer sequences in real time quantitative PCR reaction.
Pre-clinical investigation of the effect of combining the cytotoxic agent Temozolomide with a dual mTORC2 inhibitor for the treatment of glioblastoma and establishment of an imageable surgical resection model of glioblastoma
Creators: name: Sweeney, Kieron J.
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Glioblastoma is the most common primary brain tumour. It is an incurable disease and is commonly referred to as the worst of the “incurable cancers” by neurosurgeons and neuro-oncologists. It is heterogeneous on a cellular and genetic level. The genetic mutations that occur in glioblastoma lead to dysregulation of several principal pathways, the most commonly dysregulated pathways involve mTOR. mTOR is involved in the control of several cellular processes including autophagy and apoptosis. Despite maximal treatment, median survival remains abysmal ranging from 15 to 16 months. Current standard of care consists of two phases. The first phase involves maximal safe surgical resection. This intervention reduces the tumour burden and improves the efficacy of the second phase. This second phase involves chemotherapy and radiotherapy commonly referred to as the “Stupp protocol”. This phase employs a common strategy of inducing apoptosis in an attempt to control the residual disease. Within this thesis we explore both phases of treatment for glioblastoma. Firstly, we established the in vitro efficacy of the mTOR inhibitor, AZD 8055 using the glioblastoma cell line U87MG, and glioblastoma tissue derived from a patient in Norway referred to as patient 3. We then assessed the in vivo efficacy of AZD 8055 in combination with temozolomide, using the patient derived glioblastoma tumour material from patient 3, in an orthotopic bioluminescence murine model. We demonstrated that although AZD 8055 is a strong inhibitor of the mTOR pathway when used as a monotherapy or combined with temozolomide, this did not translate into either increased survival or a reduction in tumour growth in vivo. By interrogating the points of crosstalk between autophagy and apoptotic pathways, we hypothesized that mTOR inhibition induced a protective autophagy which antagonised the apoptosis induced by temozolomide. Secondly, we validated a novel animal model of surgical resection. We established that orthotopic implantation of glioblastoma cells can be safely resected, and that the residual tumour, which has invaded the surrounding brain parenchyma, can be reliability imaged in vivo. We advocated the use of this model for the investigation of local delivery of novel therapies into the surgical resection cavity or in the assessment of systemic therapeutic agents targeting residual tumour that has migrated into the normal brain parenchyma.
Evolution of Galaxies in Clusters
Creators: name: Charlot, S.
name: Silk, J.
Publisher: name: arXiv
Year: 1994
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We use new models of stellar population synthesis to estimate the fraction of stars formed during the last major bursts of star formation in E/S0 galaxies in low-redshift clusters ($z\simlt0.4$) from the spectral signatures of intermediate-age stars. We find that the mass fraction of stars formed in late bursts in early-type galaxies in clusters must have decreased smoothly with redshift, from about 8\% at $z\approx1$ to less than 1\% at $z\approx0$. This result, which we interpret as a constraint on stellar mass added in mergers, is nearly independent of the assumed ages and morphological types of the progenitor galaxies prior to the last major bursts of star formation. We then compute the implied color and 4000 Å break evolution for progenitors of E/S0 galaxies in clusters at redshifts $0\simlt z\simlt1$. We investigate a conservative model in which all present-day E/S0 galaxies are assumed to initially be elliptical galaxies and to then undergo bursts of star formation at the rate estimated from the signatures of intermediate-age stars at low redshifts. This model reproduces well the observed spread of colors and 4000 Å breaks of galaxies in high-redshift clusters, but underestimates the fraction of galaxies in the blue tail of the distribution. Such a discrepancy may be interpreted as an increasing fraction of spiral galaxies in clusters at high redshift, as suggested independently by recent {\it HST} observations of intermediate-redshift clusters. The current data do not seem to require morphological evolution of cluster galaxies out to $z\sim0.4$, but suggest that either morphological or strong luminosity evolution might have played a major role at $z\simgt0.7$.
description: 33 pages, normal TeX
Off-axis digital holography with multiplexed volume Bragg gratings
Creators: name: Puyo, Leo
name: Huignard, Jean-Pierre
name: Atlan, Michael
Publisher: name: arXiv
Year: 2018
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We report on an optical imaging design based on common-path off-axis digital holography, using a multiplexed volume Bragg grating. In the reported method, a reference optical wave is made by deflection and spatial filtering through a volume Bragg grating. This design has several advantages including simplicity, stability and robustness against misalignment.
description: 8 pages, 7 figures
Nonlinear dynamics of a semiquantum Hamiltonian in the vicinity of quantum unstable regimes
Creators: name: Kowalski, A. M.
name: Rossignoli, R.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We examine the emergence of chaos in a non-linear model derived from a semiquantum Hamiltonian describing the coupling between a classical field and a quantum system. The latter corresponds to a bosonic version of a BCS-like Hamiltonian, and possesses stable and unstable regimes. The dynamics of the whole system is shown to be strongly influenced by the quantum subsystem. In particular, chaos is seen to arise in the vicinity of a quantum critical case, which separates the stable and unstable regimes of the bosonic system.
description: 14 pages, 6 figures
Squeezed States and Uncertainty Relation at Finite Temperature
Creators: name: Hu, B. L.
name: Zhang, Yuhong
Publisher: name: arXiv
Year: 1993
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We use the quantum Brownian model to derive the uncertainty relation for a quantum open system in an arbitrarily-squeezed initial state interacting with an environment at finite temperature. We examine the relative importance of the quantum and thermal fluctuations in the evolution of the system towards equilibrium with the aim of clarifying the meaning of quantum, classical and thermal. We show that upon contact with the bath the system evolves from a quantum-dominated state to a thermal-dominated state in a time which is the same as the decoherence time calculated before in the context of quantum to classical transitions. We also use these results to deduce the conditions when the two basic postulates of quantum statistical mechanics become valid.
description: physics preprint pp93-161, TEX, 12 pages e-mail addresses: hu@umdhep.bitnet, zhang@helix.nih.gov
Additional file 6: of Participation of father in perinatal care: a qualitative study from the perspective of mothers, fathers, caregivers, managers and policymakers in Iran
Creators: name: Vahideh Firouzan
name: Noroozi, Mahnaz
name: Mirghafourvand, Mojgan
name: Farajzadegan, Ziba
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Interview guide during the focus group discussions (for health care providers) for the study conducted on participation of fathers in perinatal care from the perspective of mothers, fathers, caregivers, managers and policymakers in Tabriz Town, Iran, 2017 (See methods section for further description). (DOCX 17 kb)
Additional file 8: of Hepatitis B virus infection among pregnant women in Ethiopia: a systematic review and Meta-analysis of prevalence studies
Creators: name: Kindie Kebede
name: Dejene Abateneh
name: Alemayehu Belay
Publisher: name: figshare
Year: 2018
Subjects: subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Sub-group meta-analysis by HBV screening tools among pregnant women in Ethiopia. (DOCX 1515 kb)
Optimized Broad-Histogram Ensembles for the Simulation of Quantum Systems
Creators: name: Wessel, Stefan
name: Stoop, Norbert
name: Gull, Emanuel
name: Trebst, Simon
name: Troyer, Matthias
Publisher: name: arXiv
Year: 2007
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: The efficiency of statistical sampling in broad-histogram Monte Carlo simulations can be considerably improved by optimizing the simulated extended ensemble for fastest equilibration. Here we describe how a recently developed feedback algorithm can be generalized to find optimized sampling distributions for the simulation of quantum systems in the context of the stochastic series expansion (SSE) when defining an extended ensemble in the expansion order. If the chosen update method is efficient, such as non-local updates for systems undergoing a second-order phase transition, the optimized ensemble is characterized by a flat histogram in the expansion order if a variable-length formulation of the SSE is used. Whenever the update method suffers from slowdown, such as at a first-order phase transition, the feedback algorithm shifts weight towards the expansion orders in the transition region, resulting in a non-uniform histogram.
description: 15 pages, 13 figures