cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Assessing Vulnerability in Households and Communities Involved in Fisheries Sector Activities
Creators: name: Taves, Jessica Rebecca
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Fisheries
Aquaculture
Vulnerability
Vietnam
Development
Livelihoods

description: Global fisheries are in decline in response to intense pressure to feed a growing world population. Many of the world’s fisherpeople live in poverty and suffer disproportionately from this threat to global fish stocks due to competition for resources among other stressors. In recent years the Vietnamese government has encouraged small-scale aquaculture production for economic development and to mitigate declining fisheries livelihoods. Using data from the 2013 Vietnam Transitions Survey this paper examines different measures of household vulnerability to the declining fishery and the resulting uncertain economic future. Analysis reveals that the most vulnerable group among survey participants are those who depend primarily on extensive aquaculture for their household income. Despite the frequency of disease in fish, intensive aquaculture remains an attractive livelihood activity. Households are theoretically willing to face increased risk in exchange for greater prosperity, but are typically unable to do so due to cost-related barriers to entry.
Understanding the Mechanisms by which Interleukin (IL)-7 Down-Regulates Expression of the IL-7 Receptor Alpha-Chain (CD127) in Human CD8 T Cells
Creators: name: Al-Ghazawi, Feras
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Cytotoxic CD8 T cells
Interleukin-7

description: Interleukin (IL)-7 is an essential non-redundant cytokine and throughout the life-span of a T cell signaling via the IL-7 receptor influences cell survival, proliferation and function. It is therefore no surprise that expression of the IL-7 receptor alpha-chain (CD127) is tightly regulated. In this study I establish IL-7 down regulates CD127 gene transcription and surface protein expression in primary human CD8 T cells through two mechanisms. Upon binding IL-7, surface CD127 is rapidly internalized and phosphorylated at the critical tyrosine residue Y449. Concurrent activation of the JAK/STAT5 pathway stimulates expression of CIS, a member of the SOCS family of proteins. CIS protein already expressed at basal levels and induced by IL-7 bind directly to CD127 as demonstrated by Coimmunoprecipitation assays and colocalize with both CD127 and the early endosomal marker EEA1. Subsequent proteasomal degradation of CD127 and CIS is dependent on an E3 ligase. Through siRNA-mediated knockdowns I confirm CIS plays a predominant role in the IL-7 mediated degradation of CD127. The mechanism by which IL-7 suppresses CD127 transcripts in primary human CD8 T cells was also examined. Through qPCR and nuclear run-on assays I illustrate that IL-7 suppresses CD127 gene transcription in a time- and dose-dependent manner. The IL-7 mediated suppression of CD127 transcripts is dependent on JAK/STAT5 signaling. Notably, cycloheximide blocked IL-7’s ability to down-regulate CD127 transcripts suggesting IL-7 stimulates the de novo synthesis of a transcriptional repressor of the CD127 gene. Through PCR arrays, qPCR and Western blot analysis the IL-7 inducible transcription factor c-Myb was identified as a candidate repressor. The region within the CD127 gene promoter required for IL-7 mediated transcriptional suppression was identified through progressive truncations using firefly luciferase as a reporter gene and is located from -1760 to -2406 bp upstream of the TATA box and contains three putative c-Myb binding sites. Using siRNA-mediated knockdown and transient over-expression, I illustrate c-Myb suppresses CD127 gene transcription in primary human CD8 T cells. A thorough understanding of the mechanisms by which IL-7 regulates CD127 expression is imperative and may reveal novel insights into the contribution of abnormal IL-7 signaling to diseases affecting immune function.
Study of the Environmental Impacts of Packagings Made of Biodegradable Plastics
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2013
Subjects: subject: Abbaubarkeit
subject: Umweltverträglichkeit
subject: Gesetzgebung
subject: Rechtsvorschrift
subject: Verpackungsverordnung
subject: Werkstoff
subject: Ökobilanz
subject: Umweltauswirkung
subject: plastic waste
subject: environmental effect
subject: biodegradability
subject: waste processing
subject: Abfall | Ressourcen
subject: Waste | Resources
subject: Boden | Fläche
subject: Soil | Land
subject: Landwirtschaft

description: The market relevance and presence of packagings made of biodegradable plastics has increased over the past few years. They are primarily used as alternatives for conventional plastics such as polyethylene (PE), polypropylene (PP), polystyrene (PS), and polystyrene terephthalate (PET).
Conscience de soi et langage interne
Creators: name: Blais, Mario
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: conscience de soi
langage interne
pensée

description: L'introspection est souvent contre-intuitive. Par exemple nous croyons, intuitivement, posséder un Moi mais, en réalité, aucun percept de ce "Moi" n'est possible. De plus, notre capacité à conceptualiser le Moi est tributaire des fonctions langagières. Ce que nous observons après analyse est que la conscience de soi-même, loin d'être innée, se développe progressivement en corrélation avec le développement du langage. Le concept de Soi se développe également ainsi. Plusieurs auteurs tendent à confirmer ce fait: la capacité de référer du sujet l'amène inconsciemment à prendre conscience de lui-même. L'autoréférence est donc le critère indispensable à l'émergence d'une conscience articulée de soi-même. À l'aide de différents ouvrages consacrés à l'étude de ce domaine, nous proposons une analyse de la présente question. Le principal objectif de cette thèse est d'étudier de plus près le développement de la conscience de soi à travers une analyse des différents stades de développement chez l'enfant. Nous voulons en évaluer les caractéristiques essentielles et confirmer le rôle prépondérant du langage interne dans la capacité à devenir à la fois conscients de soi-même mais également dans la capacité à se projeter dans l'avenir (maintien du "Soi" ou "Moi" temporel). Dans la dernière section de thèse nous voulons démontrer, à l'aide d'étude de cas empiriques, que certaines lésions, particulièrement relatives aux fonctions langagières, entraînent inexorablement des répercussions sur la conscience de soi. Ainsi nous confirmons l'hypothèse de départ: la conscience articulée de soi dépend du langage interne.
Indigenous entrepreneurship: what, when, how and why?
Creators: name: Foley, Dennis
Publisher: name: Swinburne
Year: 2024

description: Is this an area of legitimate academic endeavour, or has this become the social experiment of the business management minded scholar who perhaps sees it as a 'trendy - exotic' area of study? Correspondingly, do researchers view this as an area of study with a mythical bottomless bucket of government funding to support their academic conquest? Or is this a serious area of research that is desperately needed for government bodies, agencies and NGOs to understand economic alternatives that will improve the social standing of Indigenous people within what is stereotypically seen as a welfare dependant group within the greater Australian society. Existing literature will be reviewed. Do we understand Indigenous entrepreneurship? This paper will begin to tackle issues not normally discussed outside of Indigenous networks. These issues are broad and cover a wide range that are not politically motivated, however the contemporary political environment that faces Indigenous Australia, and the Indigenous Australian Entrepreneur is not one of certainty. The Indigenous Australian entrepreneur is not the exotic subject matter; the object of research. Rather; they are a member of Australian society whose economic, cultural and social well-being is ultimately the purpose of our research.
Effects of the Presence of Obstacles on the Attentional Demand of Blind Navigation in Young and Elderly Subjects
Creators: name: Richer, Natalie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: Attentional demands
Navigation
Aging
Reaction time
Obstacle avoidance
Sensory deprivation

description: The ability to navigate with limited vision is a skill that is often employed in our daily lives. Navigating without vision to a remembered target has previously been studied. However, not much is known about the attention required to perform blind navigation. We examined the effect of aging and presence of obstacles on the attentional demands of blind navigation. We evaluated reaction time, navigation errors and average walking speed in an 8 meter walking path, with or without obstacles, in the absence of vision. Results showed that older participants had increased reaction time and increased linear distance travelled as opposed to young participants, that obstacles increased reaction time and decreased average walking speed in all participants, and that emitting the reaction time stimulus early in the trial increased the linear distance travelled. Interpretation of the results suggests that aging and presence of obstacles augments the attentional demands of blind navigation.
Places of Tradition, Places of Research: The Evaluation of Traditional Medicine Workshops Using Culturally and Locally Relevant Methods
Creators: name: Barwin, Lynn
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: Aboriginal health
traditional medicine
self-care
capacity (re)building
decolonizing methodology
self-determination
art voice
culturally relevant research
place-based methods
decolonizing methods
Manitoulin School of Art
Indigenous Worldview

description: This thesis examines how traditional medicine workshops offered by an Aboriginal health centre contribute to capacity re-building through self-care in two local communities in Manitoulin Island, Ontario. Health disparities that exist between Aboriginal people and the rest of the population have prompted a need to better understand health determinants that are of relevance in these communities including the importance of culture, tradition, and self-determination. A variety of qualitative methods were employed in this work including in-depth interviews, focus groups and “art voice.” The use of art voice on Manitoulin Island advances decolonizing methodologies by emphasizing how the incorporation of locally and culturally relevant methods or “methods-in-place,” is an effective way to engage communities in the research process. Results show the need to approach traditional teachings, health programs, and research from an Aboriginal worldview and indicate that more frequent workshops are required to empower youth and adults to practice and share traditional knowledge. Furthermore, a continuum exists in which the interest in language, culture, and tradition increases with age. Capacity can therefore be re-built over time within communities promoting autonomy and self-determination through self-care. Findings can be expected to further inform the traditional programming in participating communities, enhance existing Aboriginal determinants of health models by including traditional medicine as an element of self-care, and can act as a springboard for the inclusion of unique place-based methods into community-based research projects in the future.
Supplementary document for Femtosecond Diode Based Time Lens Laser for Multiphoton Microscopy - 5371469.pdf
Creators: name: Simmons, Yonge
name: Underwood, Kenneth
name: Supekar, Omkar
name: Heffernan, Brendan
name: Welton, Tarah
name: Gibson, Emily
name: Gopinath, Juliet
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Photonics and Electro-Optical Engineering (excl. Communications)
Neuroscience

description: Revised supplemental document
Ce- and B-Doped Silica Fibers for Monitoring Low-Energy Proton Beams on a Medical Cyclotron
Creators: name: Hoehr, Cornelia
name: Hanna, Matthew
name: Zeisler, Stefan
name: Penner, Crystal
name: Stokely, Matthew
name: Dehnel, Morgan
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2020

description: Many medical isotopes can be produced on a small cyclotron. The alignment and profiles of low-energy proton beams from cyclotrons used for medical radioisotope production, such as the TR13 cyclotron at TRIUMF, Canada, cannot be directly quantified during dose delivery with simultaneous constant feedback and sharp spatial resolutions. Doped silica fibers are a potential solution that has been tested at TRIUMF. To measure the effects of irradiation inside an isotope production target, we attached fibers to the outside of an 18O gas target and measured the light output during irradiation. Different dopants, fiber diameters, and target materials were investigated. It was found that 200 µm diameter Ce- and B-doped fibers produce signals linearly proportional to the beam current. This only deviated when the target was moved such that the beam was steered into the target wall, increasing the production of prompt radiation and causing the beam current to decrease but the fiber signal to increase. With the technique described here, the beam can be monitored on the target, including its steering and its overall alignment with the target.
A holistic modeling framework for estimating the influence of climate change on indoor air quality
Creators: name: Birmili, Wolfram
name: Salthammer, Tunga
name: Zhao, Jiangyue
name: Schieweck, Alexandra
Publisher: name: My University
Year: 2022
Subjects: Exposition

description: The IPCC 2021 report predicts rising global temperatures and more frequent extreme weather events in the future, which will have different effects on the regional climate and concentrations of ambient air pollutants. Consequently, changes in heat and mass transfer between the inside and outside of buildings will also have an increasing impact on indoor air quality. It is therefore surprising that indoor spaces and occupant well-being still play a subordinate role in the studies of climate change. To increase awareness for this topic, the Indoor Air Quality Climate Change (IAQCC) model system was developed, which allows short and long-term predictions of the indoor climate with respect to outdoor conditions. The IAQCC is a holistic model that combines different scenarios in the form of submodels: building physics, indoor emissions, chemical-physical reaction and transformation, mold growth, and indoor exposure. IAQCC allows simulation of indoor gas and particle concentrations with outdoor influences, indoor materials and activity emissions, particle deposition and coagulation, gas reactions, and SVOC partitioning. These key processes are fundamentally linked to temperature and relative humidity. With the aid of the building physics model, the indoor temperature and humidity, and pollutant transport in building zones can be simulated. The exposure model refers to the calculated concentrations and provides evaluations of indoor thermal comfort and exposure to gaseous, particulate, and microbial pollutants. © 2022 The Authors
In the age of over-sharing and the death of shame
Creators: name: Tofts, Darren
Publisher: name: Swinburne
Year: 2024

description: Let's assume, for the sake of argument, that there is such a thing as 'the social networking revolution', as if there was nothing of the kind before the evangelistic Web 2.0, and tell me that MySpace is not the 'horror vacui' of our times. I've already digressed into polemic. Let's begin again, with a question: what is the current state of media education in the context of social networking? Debates around nomenclature, the novelty or regressive nature of new formations are of course perennial, shifting with trends in industry, emergent communication technologies and constant updates within contemporary 'app' culture. The old chestnut 'new media art' seems to have finally succumbed to the dustbin of history, absorbed into the malleable and apparently more robust discourse of 'digital media' (though media or digital art doesn't seem to trouble the attention of arts critics too often these days). Similarly, the pervasive formations of mobility, customisation and social networking have taken centre stage as inflections of the contemporary mediascape.
Supplementary document for Femtosecond Diode Based Time Lens Laser for Multiphoton Microscopy - 5371469.pdf
Creators: name: Simmons, Yonge
name: Underwood, Kenneth
name: Supekar, Omkar
name: Heffernan, Brendan
name: Welton, Tarah
name: Gibson, Emily
name: Gopinath, Juliet
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Photonics and Electro-Optical Engineering (excl. Communications)
Neuroscience

description: Revised supplemental document
Where do migrant workers fit into the picture? The apparent invisibility of cultural diversity factors in industrial relations research
Creators: name: Bertone, Santina
Publisher: name: Swinburne
Year: 2024

description: This paper asks why there is a relatively little focus and research in Australian industrial relations on the role of immigrants and their interface with workplace restructuring, workforce development, enterprise bargaining and union participation. Australia has the highest proportion of overseas born workers of any developed country with over 200 language groups represented, and a strong ongoing immigration program which is filling a wide range of skill shortages. The issues and challenges this raises have been long documented by other disciplines which are often seen as 'feeder' disciplines for industrial relations. Immigration is likely to be a continuing factor in economic development at national and enterprise level, with significant implications for industrial relations on the ground. A number of possible explanations for this gap in research and thinking are presented and some future strategies are outlined.
Supplementary document for High efficiency broadband polarizationindependent binary fused silica gratings for large astronomical telescopes - 5372203.pdf
Creators: name: Wang, Yanan
name: Chen, Zhiwen
name: Cai, Maoqi
name: Qiu, Keqiang
name: Liu, Zhengkun
name: Zhu, Qingfeng
name: Hong, Yilin
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Simplified model method and exposure
Vaccination of BALB/c Mice with an Alhydrogel Adjuvanted Whole Cell Trichomonas vaginalis Formulation
Creators: name: Smith, Jeffrey D.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: vaccine
Trichomonas vaginalis
microbiology
immunology
animal model
aluminum hydroxide
Alhydrogel
disease prevention
HIV susceptibility
vaginitis
immune response

description: A human safe, Alhydrogel adjuvanted whole cell Trichomonas vaginalis vaccine was tested for efficacy in a BALB/c mouse model of vaginal infection. Additionally, the systemic and local immune response were measured. Vaccination reduced incidence and increased clearance of infection, and induced both systemic and local humoral immune responses. CD4+ cells were detected in vaginal tissues following intravaginal challenge with T. vaginalis, but were not seen in uninfected mice. CD4+ cells were detected more often, earlier, and in greater numbers in vaccinated vaginal tissues compared to unvaccinated controls. Presence of CD4+ T cells following infection can have significant implications of increasing HIV susceptibility and transmission. These data suggest that the vaccine induces local and systemic immune responses, and confers significantly greater protection against vaginal challenge than unvaccinated vaginal challenge. These data support the potential for a human vaccine against T. vaginalis infection that could also impact the incidence of HIV infections.
Genome assembly of the basket willow, Salix viminalis, reveals earliest stages of sex chromosome expansion
Creators: name: Almeida, Pedro
name: Proux-Wera, Estelle
name: Churcher, Allison
name: Soler, Lucile
name: Dainat, Jacques
name: Pucholt, Pascal
name: Nordlund, Jessica
name: Martin, Tom
name: Rönnberg-Wästljung, Ann-Christin
name: Nystedt, Björn
name: Berlin, Sofia
name: Mank, Judith E
Publisher: name: BioMed Central
Year: 2020

description: Background: Sex chromosomes have evolved independently multiple times in eukaryotes and are therefore considered a prime example of convergent genome evolution. Sex chromosomes are known to emerge after recombination is halted between a homologous pair of chromosomes, and this leads to a range of non-adaptive modifications causing gradual degeneration and gene loss on the sex-limited chromosome. However, the proximal causes of recombination suppression and the pace at which degeneration subsequently occurs remain unclear. Results: Here, we use long- and short-read single-molecule sequencing approaches to assemble and annotate a draft genome of the basket willow, Salix viminalis, a species with a female heterogametic system at the earliest stages of sex chromosome emergence. Our single-molecule approach allowed us to phase the emerging Z and W haplotypes in a female, and we detected very low levels of Z/W single-nucleotide divergence in the non-recombining region. Linked-read sequencing of the same female and an additional male (ZZ) revealed the presence of two evolutionary strata supported by both divergence between the Z and W haplotypes and by haplotype phylogenetic trees. Gene order is still largely conserved between the Z and W homologs, although the W-linked region contains genes involved in cytokinin signaling regulation that are not syntenic with the Z homolog. Furthermore, we find no support across multiple lines of evidence for inversions, which have long been assumed to halt recombination between the sex chromosomes. Conclusions: Our data suggest that selection against recombination is a more gradual process at the earliest stages of sex chromosome formation than would be expected from an inversion and may result instead from the accumulation of transposable elements. Our results present a cohesive understanding of the earliest genomic consequences of recombination suppression as well as valuable insights into the initial stages of sex chromosome formation and regulation of sex differentiation.
Automatic Generation of Hardware for Custom Instructions
Creators: name: Necsulescu, Philip I
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: FPGA
Instruction Set Extension
ISE
Custom Instruction
Automatic Hardware Generation
Assisted Hardware Generation
VHDL
Embedded Systems
Custom Hardware

description: The Software/Hardware Implementation and Research Architecture (SHIRA) is a C to hardware toolchain developed by the Computer Architecture Research Group (CARG) of the University of Ottawa. The framework and algorithms to generate the hardware from an Intermediate Representation (IR) of the C code is needed. This dissertation presents the conceiving, design, and development of a module that generates the hardware for custom instructions identified by specialized SHIRA components without the need for any user interaction. The module is programmed in Java and takes a Data Flow Graph (DFG) as an IR for input. It then generates VHDL code that targets the Altera FPGAs. It is possible to use separate components for each operation or to set a maximum number for each component which leads to component reuse and reduces chip area use. The performance improvement of the generated code is compared to using only the processor’s standard instruction set.
Madman in the house: understanding the role of distribution companies in sustaining culture
Creators: name: Bainbridge, Jason
name: Norris, Craig
Publisher: name: Swinburne
Year: 2024

description: This paper is part of a larger research project looking at the role of Australian media companies in sustaining fan culture, and Australian investment in global popular culture. The specific focus is on Madman Entertainment—one of the most successful DVD and merchandise distribution companies in Australia, and the leading distributor of anime with over ninety percent of the market share. The paper explores the ways in which Madman has become a part of the simultaneous globalization and localisation of Japanese cultural products, and sets out to show how profiling such a company can also provide some insight into the changing role of fans in relation to their capacity to drive innovation and investment in popular culture.
A SNP Associated With Autism Affects Dlx5/Dlx6 Regulation in the Forebrain
Creators: name: Lesage-Pelletier, Cindy
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: SNP
Autism
mouse behaviour
Enhancer
Telencephalon

description: Autism is a severe childhood neuropsychiatric condition characterized by impairments in socialization and communication, and by restricted and repetitive behaviours. Autism spectrum disorder (ASD) is a complex and largely unknown disease with a strong genetic basis, multiple genes involved and environmental factors determining its phenotype. Interestingly, the DLX1/DLX2 and DLX5/DLX6 bigene clusters are located in autism susceptibility loci and Dlx genes are involved in GABAergic interneurons differentiation and migration to the cortex during forebrain development. Dlx gene expression is controlled by different cis-regulatory elements. Of these, 4 are active in the forebrain, URE2, I12b, I56ii and I56i. In order to determine the role of the DLX genes in ASD, variants were found in gene exons and in cis-regulatory elements in autistic individuals. A single nucleotide polymorphism (SNP), a change of an adenine for a guanine, was identified in I56i enhancer. Finding a SNP in I56i was very surprising considering that it is located in a Dlx binding motif highly conserved among >40 species. We showed, using in vitro approaches, that the presence of this SNP affects the affinity of Dlx for their binding site and reduces the transcriptional activation of the enhancer. The SNP also affects activity of the I56i enhancer in transgenic mice. In order to determine the real impact of the SNP in vivo, mutant mice harboring the SNP in their I56i enhancer were produced. That involved the insertion of the I56i enhancer with the SNP, using homologous recombination in mouse embryonic stem cells to replace the wild type version of the enhancer. With these mutant mice, we demonstrated that, in vivo, this SNP reduces Dlx5 and Dlx6 expression in the forebrain. Furthermore, this decrease in Dlx5/Dlx6 expression could affect the differentiation and/or migration of specific populations of inhibitory interneurons in the forebrain. No distinct iv behavioural phenotypes were observed between wild type mice and those carrying the SNP, during social interaction and anxiety tests. Therefore, these results suggest that even a subtle change in a regulatory element can have an impact in the development of the forebrain and may even contribute to disorders such as autism.
Children's Mental Health Is a Unique Risk Factor for Poor Academic Achievement: Results from a Longitudinal Study of Canadian Children
Creators: name: Tsar, Vasilinka
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: Children's mental health
Academic achievement

description: Concurrent and prospective relationships between symptoms of depression, anxiety, attention deficit/hyperactivity disorder (ADHD), and conduct disorder (CD) and academic achievement were examined in a large sample of Canadian children. Students in Grade 5 (N = 715) completed the depression and anxiety subscales of the Behaviour Assessment System for Children – Second Edition. Parents reported on their child’s symptoms of ADHD and CD using the Brief Child and Family Phone Interview. Academic achievement was measured using teacher-rated learning skills and students’ grade point average (GPA) from their Ontario Student Record (OSR) in fifth grade and again in sixth grade (N = 627). Symptoms of depression, anxiety, ADHD, and CD were significantly negatively correlated with academic achievement at Time 1 and Time 2. After controlling for child’s sex, household income, maternal education, and days absent, children’s mental health problems accounted for an additional 12% and 11% of the variability in their Time 1 mean ratings of learning skills and GPA, respectively. Only symptoms of ADHD predicted Time 2 GPA (1% of the variance) after controlling for Time 1 GPA and other sociodemographic variables. Findings highlight the unique contribution of mental health problems in predicting academic achievement and point to the need to promote children’s mental health in schools.
Genome-Wide Studies on the Molecular Functions of Pax7 in Adult Muscle Satellite Cells
Creators: name: Punch, Vincent
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: Pax7
Skeletal muscle
Transcriptional networks
Satellite cells
Stem cells
Regeneration

description: Pax3 and Pax7 belong to a family of conserved transcription factors that play important and diverse roles in development. In the embryo, they carry out similar roles in neural and somite development, but Pax7 fails to compensate for critical functions of Pax3 in the development of limb musculature. Conversely, in the adult, Pax7 is necessary for the maintenance and survival of muscle satellite cells, whereas Pax3 cannot effectively fulfill these roles in the absence of Pax7. To identify the unique roles of Pax7 in adult muscle cells, we have analyzed global binding of Pax3 and Pax7 by ChIP-Seq. Here, we show that despite highly homologous DNA-binding domains, the majority of binding sites are uniquely recognized by Pax7 and are enriched for homeobox motifs. Genes proximal to conserved, unique Pax7 binding sites cluster into specific functional groups which may reflect the unique biological roles of Pax7. Combining Pax7 binding sites with gene expression data, we describe the regulatory networks directed by Pax7 and show that Pax7 binding is associated with positive gene regulation. Moreover, we show Myf5 is a direct target of Pax7 and identify a novel binding site in the satellite cell control region upstream of Myf5.
Supplementary document for Transmission properties of microwaves at an optical Weyl point in a three-dimensional chiral photonic crystal - 5372344.pdf
Creators: name: Takahashi, Shun
name: Tamaki, Souma
name: Yamashita, Kenichi
name: Yamaguchi, Takuya
name: Ueda, Tetsuya
name: Iwamoto, Satoshi
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental material
Multi layered narratives and changing identities: making sense of student experience
Creators: name: Hore, Roslyn
Publisher: name: Swinburne
Year: 2024

description: Despite decades of research, inequalities still exist in the Australian education system, as in Western countries in general. Research into the matter has taken many directions with parents, teachers and children themselves all coming under close scrutiny (Hore and Ballantyne 2006, Darian-Smith and Factor 2005, Chin and Phillips 2004, Taylor et al 2004, Dodici et al 2003, Rowe 2003, Divine 2002, Edwards and Aldred 2002). When a child fails to thrive in the classroom cause is often sourced to an individual such as the teacher, the parent or the child itself. I suggest a narrow focus on the individual is perhaps one of the reasons for continued educational inequality and is the direct result of peoples' theories or beliefs about the 'self'.
Role of hydroxamic acids in the resistance of maize, Zea mays L., to western corn rootworm, Diabrotica virgifera virgifera LeConte.
Creators: name: Xie, Yongshou.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1991
Subjects: subject: Biology, Botany.

description: The role of the maize secondary metabolites, hydroxamic acids, in the interactions of maize, Zea mays L., and western corn rootworm, Diabrotica virgifera virgifera LeConte, was investigated under greenhouse and laboratory conditions. Four compounds found in maize roots, 2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-(4H)-one(DIMBOA), 2,4-dihydroxy-7,8-dimethoxy-1,4-benzoxazin-3(4H)-one(DIM$\sb2$BOA), 2-hydroxy-7-methoxy-14-benzoxazin-3(4H)-one (HMBOA), and 6-methoxybenzoxazolinone(MBOA), were separated and identified. The highest concentrations of DIMBOA equivalents were found in 4 week old maize root extracts, which overlapped with the time of development of western corn rootworm larvae. Hydroxamic acids and related compounds are concentrated in the cortex of maize roots, which is the feeding site of western corn rootworm larvae. The total concentration of related compounds and the concentration of each individual compound except HMBOA in the complete organ of nodal roots was significantly higher than in any other part of maize roots. The high concentrations of these substances in the cortex of maize root may be relevant to the resistance of maize varieties to subterranean pest insects. Thirty-three inbred maize lines from different latitudinal geographical regions were surveyed for concentrations of hydroxamic acids. All were found to contain four major hydroxamates: DIMBOA, DIM$\sb2$BOA, HMBOA, and MBOA. Differences in concentrations of hydroxamic acids characterized the different geographical groups, and the intermediate temperate region (ITR) group had higher levels of all individual compounds, especially DIMBOA equivalents and the total amount of hydroxamic acids. A positive correlation between concentration of DIMBOA in maize roots and in maize leaves was found. DIMBOA, the major hydroxamic acid present in maize roots, and MBOA, the degradation product of DIMBOA, were studied for their toxic and deterrent effects on western corn rootworm larvae. Exogenously applied DIMBOA and MBOA separately caused mortality in western corn rootworm larvae feeding on fresh corn roots. The deleterious effects of DIMBOA and MBOA on western corn rootworm larvae are possibly due to both feeding deterrence and toxicity. The results indicated that the high DIMBOA line (but not the low DIMBOA line) stressed western corn rootworm larvae to produce inferior adults. ITR 3872 (high DIMBOA) plants showed significantly less damage than NTR-2 Ger. 4042 (low DIMBOA) plants in almost all plant parameters measured. The results suggest that hydroxamic acids may in some instances contribute to the resistance of maize to western corn rootworm larvae. (Abstract shortened by UMI.)
Supplementary document for Transmission properties of microwaves at an optical Weyl point in a three-dimensional chiral photonic crystal - 5372344.pdf
Creators: name: Takahashi, Shun
name: Tamaki, Souma
name: Yamashita, Kenichi
name: Yamaguchi, Takuya
name: Ueda, Tetsuya
name: Iwamoto, Satoshi
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: Supplemental material
A collaborative evaluation of LC-MS/MS based methods for BMAA analysis: soluble bound BMAA found to be an important fraction
Creators: name: Faassen, Elisabeth J.
name: Antoniou, Maria G.
name: Beekman-Lukassen, Wendy
name: Blahova, Lucie
name: Chernova, Ekaterina
name: Christophoridis, Christophoros
name: Combes, Audrey
name: Edwards, Christine
name: Fastner, Jutta
name: Harmsen, Joop
name: Hiskia, Anastasia
name: Ilag, Leopold L.
name: Kaloudis, Triantafyllos
name: Lopicic, Srdjan
name: Lürling, Miquel
name: Mazur-Marzec, Hanna
name: Meriluoto, Jussi
name: Porojan, Cristina
name: Viner-Mozzini, Yehudit
name: Zguna, Nadezda
Publisher: name: My University
Year: 2016
Subjects: Phytoplankton
Meeresfrüchte

description: Exposure to â-N-methylamino-l-alanine (BMAA) might be linked to the incidence of amyotrophic lateral sclerosis, Alzheimers disease and Parkinsons disease. Analytical chemistry plays a crucial role in determining human BMAA exposure and the associated health risk, but the performance of various analytical methods currently employed is rarely compared. A CYANOCOST initiated workshop was organized aimed at training scientists in BMAA analysis, creating mutual understanding and paving the way towards interlaboratory comparison exercises. During this workshop, we tested different methods (extraction followed by derivatization and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) analysis, or directly followed by LC-MS/MS analysis) for trueness and intermediate precision. We adapted three workup methods for the underivatized analysis of animal, brain and cyanobacterial samples. Based on recovery of the internal standard D3BMAA, the underivatized methods were accurate (mean recovery 80%) and precise (mean relative standard deviation 10%), except for the cyanobacterium Leptolyngbya. However, total BMAA concentrations in the positive controls (cycad seeds) showed higher variation (relative standard deviation 21%-32%), implying that D3BMAA was not a good indicator for the release of BMAA from bound forms. Significant losses occurred during workup for the derivatized method, resulting in low recovery (<10%). Most BMAA was found in a trichloroacetic acid soluble, bound form and we recommend including this fraction during analysis.Quelle: http://www.mdpi.com
Corporate venture capital in East Asia - analysing the survival and the probability of going public of South Korean portfolio companies
Creators: name: Johann, Tobias
name: Peters, Alexander
name: Klandt, Heinz
Publisher: name: Swinburne
Year: 2024

description: Overriding rationale of the study is to analyse the performance of South-Korean portfolio companies that received corporate venture capital funding, focusing on their probability of survival and of going public. The underlying method used is a survival analysis conducted in the form of bivariate life tables, survival functions, and the multivariate Cox Proportional Hazard model. Eight factors are tested for their influence. The data sample contains 370 portfolio companies. The findings suggest a general probability of survival of 81.5 percent while the general probability of going public is computed as 12.6 percent within the first six years after foundation.
Supplementary document for Self-powered visible photodetector with fast-response speed and high stability based on assembled (In,Ga)N nanowires - 5372494.pdf
Creators: name: Jiang, Min
name: Zhang, Jianya
name: Xing, Zhiwei
name: Wu, Dongmin
name: Qin, Hua
name: Bian, Lifeng
name: Zhao, Yukun
name: Yang, Wenxian
name: Lu, Shulong
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supporting information for manuscript
Development of tunable Alexandrite lasers
Creators: name: Liang, Meizhen
Publisher: name: Imperial College London
Year: 2024

description: The aim of this work is to develop tunable Alexandrite lasers, particularly focusing on generating notable Q-switched pulses and frequency-doubling with high energy and a widely tunable wavelength range for a variety of applications. Diode-pumped continuous-wave (CW) Alexandrite lasers are presented, with various laser cavity designs and pump arrangements. Lasers with high power, high slope efficiency, a wide tuning range, and good beam quality are achieved with single- and dual-end pumping from fibre-delivered and free-space diode modules. Side-pumped Alexandrite lasers are demonstrated with laser cavities of linear and bounce geometry, and single-pass and double-pass pump arrangements. Diode-pumped electro-optic (EO) and acousto-optic (AO) Q-switched Alexandrite lasers are investigated. The first ever AO Q-switched diode-pumped Alexandrite laser with a broad tuning range from 719 to 787 nm is presented, achieving remarkable high pulse energy of 2.6 mJ, short pulse duration of 75 ns, and high pulse peak power of 35 kW. This development is of great interest in numerous fields, such as laser medicine, lidar systems, and photoacoustic imaging. Second harmonic generation (SHG) based on the EO and AO Q-switched Alexandrite lasers is produced, offering UV pulses with high pulse energy of 0.66 mJ, high conversion efficiency of 32.9\%, and broad tunability from 361 to 391 nm. The widely tunable frequency-doubled UV has great potential in multiple applications including biomedical analyses and laser-based lidar systems.
Chemikalienauswahl und -anwendung in kleinen und mittelständischen Unternehmen
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2014
Subjects: subject: Kleine und mittlere Unternehmen
subject: Chemikalien
subject: Kleine und mittelständische Unternehmen
subject: Chemikalien
subject: Chemicals

description: Das Umweltbundesamt hat 2008-2010 auf dem aktuellen Stand der Fachdiskussionen Kriterien für die nachhaltige Auswahl und Anwendung von Chemikalien zusammengeführt und in einen Leitfaden für kleine und mittlere Unternehmen (KMU) münden lassen. Diese Kriterien und das im Leitfaden entwickelte systematische Vorgehen sollten im Rahmen des nun
abgeschlossenen Projekts anhand praktischer Beispiele und Referenzerfahrungen weiter erprobt und analysiert werden.
Quelle: www.umweltbundesamt.de
description: Das Umweltbundesamt hat 2008-2010 auf dem aktuellen Stand der Fachdiskussionen Kriterien für die nachhaltige Auswahl und Anwendung von Chemikalien zusammengeführt und in einen Leitfaden für kleine und mittlere Unternehmen (KMU) münden lassen. Diese Kriterien und das im Leitfaden entwickelte systematische Vorgehen sollten im Rahmen des nunabgeschlossenen Projekts anhand praktischer Beispiele und Referenzerfahrungen weiter erprobt und analysiert werden.
Investigation of portal vein blood flow in cirrhotic portal hypertension using computer-based and physical modelling methods
Creators: name: Petkova, Svetla
Publisher: name: Swinburne
Year: 2024

description: Portal hypertension commonly accompanies liver cirrhosis and complicates the condition by adding extra risk to the patient survival chances. This thesis investigates the blood flow through the portal vein in portal hypertension using a combination of physical experiments and computer modelling and simulations. Tissue culturing techniques are discussed and a novel design bioreactor is developed to accommodate the specific requirements of such a system within the in vitro growth of a blood vessel on biodegradable scaffold. That bioreactor is used for the physical experiments and Laser Doppler Anemometry measurements and can be adopted for a range of tissue engineering purposes. Computational Fluid Dynamics using commercially available software to create non-Newtonian flow representations in idealised portal vein model with and without additional obstructions is shown to have good agreement with the experiments. The model provides a range of useful and otherwise difficult to get information about the flow of whole blood and each blood cells group in terms of velocity, particle paths, pressure, strain, wall shear stress and combinations of those parameters. The research presented in this work shows the impact of additional obstructions within the portal vein on the flow, and the need to further investigate the apparent impact the different blood cell types (their size and concentration) have on the overall flow pattern. It is important to understand the factors impacting on the flow as they are a determining factor in patient with liver cirrhosis and portal hypertension survival chances.
Supplementary document for Short-circuited stub-loaded spoof surface plasmon polariton transmission lines with flexibly controllable lower out-of-band rejections - 5375702.pdf
Creators: name: Zhang, Dawei
name: Sun, Yaxiu
name: Zhang, Kuang
name: Wu, Qun
name: Jiang, Tao
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Figure and Table
Framework of Estimation of the Lateral Earth Pressure on Retaining Structures with Expansive and Non-expansive Soils as Backfill Material Considering the Influence of Environmental Factors
Creators: name: Guo, Jiaying
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Expansive soils
Retaining structures
Lateral earth pressure

description: Lateral earth pressures (LEP) that arise due to backfill on retaining structures are typically determined by extending the principles of saturated soil mechanics. However, there is evidence in the literature to highlight the LEP on retaining structures due to the influence of soil backfill in saturated and unsaturated conditions are significantly different. Some studies are reported in the literature to interpret the variation of LEP on the retaining structures assuming that the variation of matric suction in unsaturated backfill material is hydrostatic (i.e. matric suction is assumed to decrease linearly from the surface to a value of zero at the ground water table). Such an assumption however is not reliable when the backfill behind the retaining wall is an expansive soil, which is extremely sensitive to the changes in variation of water content values. Significant volume changes occur in expansive soils due to the influence of environmental factors such as the infiltration and evaporation. In addition to the volume changes, the swelling pressure of the expansive soils also varies with changes in water content and can significantly influence the LEPs behind the retaining wall. In this thesis, a framework for estimating the LEPs of unsaturated soils is proposed considering the variation of matric suction with respect to various water flow rates (i.e. infiltration and evaporation). The proposed approach is extended for expansive and non-expansive soils in this thesis taking into account of the influence of both the cracks and the lateral swelling pressure with changes in water content. A program code LEENES (Lateral pressure estimation on retaining walls taking account of Environmental factors for Expansive and Non-Expansive Soils) in MATLAB is written to predict the LEP. The program LEENES is valuable tool for geotechnical engineers to estimate the LEPs on retaining structures for various scenarios that are conventionally encountered in geotechnical engineering practice. The studies presented in this thesis are of interest to the practitioners who routinely design retaining walls with both expansive and non-expansive soils as backfill material.
Diversité floristique et production de biomasse des macrophytes des marais de Smir
Creators: name: Ennabili, Abdeslam
name: Ater, Mohammed
Publisher: name: figshare
Year: 2020
Subjects: subject: Botany
subject: 60204 Freshwater Ecology
subject: FOS: Biological sciences
subject: 60310 Plant Systematics and Taxonomy

description: According to biotopes diversity, the Smir Marshes (M'diq, NW of Morocco) is considered as the unique representative wetland of Mediterranean ecosystems of the western Rif. Floristic inventories and vegetation profiles were established and 88 wetland species were identified. Vegetal communities were identified and their ecology was studied. The evaluation of aboveground maximal biomass in 13 plant groupings underlines three plant groups; those biomass reached 84.3 g/m2, 1076 g/m2 and 2233 g/m2 respectively. This distinction was determined exdusively by plant size and population density. The development of different plant groupings was discussed according to local conditions and major planning works.