cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
MOESM6 of Characterization of the non-glandular gastric region microbiota in Helicobacter suis-infected versus non-infected pigs identifies a potential role for Fusobacterium gastrosuis in gastric ulceration
Creators: name: ChloĂŤ De Witte
name: Demeyere, Kristel
name: Bruyckere, Sofie De
name: Taminiau, Bernard
name: Daube, Georges
name: Ducatelle, Richard
name: Meyer, Evelyne
name: Haesebrouck, Freddy
Publisher: name: Figshare
Year: 2019
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 6. The number of F. gastrosuis bacteria in the different stomach regions of H. suis-positive and -negative 2â  3 months old pigs (A), 6â  8 months old pigs (B), adult sows (C) and the pigs used for the metagenomics study (D). Data are shown as log10 values of the average number of F. gastrosuis bacteria per mg tissue with standard deviation. Statistical differences were calculated using the non-parametric Kruskal-Wallis H test. *, p < 0.05.
Neuroanatomy of fragile X syndrome is associated with aberrant behavior and the fragile X mental retardation protein (FMRP)
Creators: name: Thompson, Paul M.
name: Hall, Scott S.
name: Gothelf, Doron
name: O'Hara, Ruth
name: Erba, Heather W.
name: Furfaro, Joyce A.
name: Piven, Joseph
name: Kraemer, Helena C.
name: Hoeft, Fumiko
name: Hayashi, Kiralee M.
name: Reiss, Allan L.
name: Eckert, Mark A.
name: Golianu, Brenda
name: Patnaik, Swetapadma
name: Ringel, Jessica
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: To determine how neuroanatomic variation in children and adolescents with fragile X syndrome is linked to reduced levels of the fragile X mental retardation-1 protein and to aberrant cognition and behavior.
Additional file 3 of Survival nomograms for colorectal carcinoma patients with lung metastasis and lung-only metastasis, based on the SEER database and a single-center external validation cohort
Creators: name: Liu, Lin-Lin
name: Sun, Jun-Die
name: Xiang, Zuo-Lin
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: Plant Biology

description: Additional file 3: Supplemental Table 3. Clinical and pathological characteristics, treatment modalities, and outcomes.
Treating obstructive sleep apnea in adults with epilepsy: A randomized pilot trial
Creators: name: Vaughn, B. V.
name: Chervin, R. D.
name: Weatherwax, K. J.
name: Foldvary-Schaefer, N.
name: Wang, L.
name: Song, Y.
name: Malow, B. A.
name: Selwa, L. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: OBJECTIVE: Small uncontrolled series suggest that treatment of obstructive sleep apnea (OSA) in patients with epilepsy may improve seizure control. Prior to conducting a definitive randomized controlled trial, we addressed critical design issues in a pilot study.

METHODS: We identified a cohort of adult patients with medically refractory epilepsy and coexisting OSA, documented by polysomnography (PSG). After an 8-week baseline period, subjects with OSA were randomized to therapeutic or sham continuous positive airway pressure (CPAP) for 10 weeks. Subjects maintained seizure calendars and antiepileptic drug dosages were held constant.

RESULTS: Sixty-eight subjects with suspected OSA were enrolled and 35 subjects randomized to therapeutic CPAP (22 subjects) or sham (13 subjects) CPAP. Male gender and an elevated sleep apnea questionnaire score were predictive of OSA on PSG. Nineteen subjects in the therapeutic group and all 13 subjects in the sham group completed the trial. Baseline apnea-hypopnea index (AHI) and CPAP adherence were comparable between groups. A significant reduction in AHI was observed in the therapeutic CPAP group as compared to the sham group. Subjects, study coordinators, and principal investigators were unable to predict treatment allocation.

CONCLUSIONS: This pilot study provided critical information related to study design and feasibility for planning a comprehensive trial to test the hypothesis that treating obstructive sleep apnea in patients with epilepsy improves seizure control.
Selecting Method of Sensitive Agricultural Products in FTA Negotiations Focused on Food Crops, Animal Products, Dairy Products in RCEP Negotiation
Creators: name: Chung, Daehee
name: Chung, Daehee
Publisher: name: Unknown
Year: 2014
Subjects: subject: International Relations/Trade
subject: tariff protection index
subject: free trade agreement; FTA
subject: sensitive products

description: The selection of sensitive agricultural products is a necessary and important part of Free Trade Agreement(FTA) negotiations due to its consequential impacts on agricultural markets of the country. However, there is no standard method to select sensitive agricultural products because the agricultural sectors of FTA partner countries are different. Therefore, selecting sensitive agricultural products is difficult and has to consider various economic factors including potential ripple effects in the previous FTAs, which are already signed and implemented. This study presented a method for selecting sensitive agricultural products in RCEP negotiations using 20 items of food crops, livestock products, and dairy products. This study selected sensitive agricultural products based on three factors: 1) the export potential in consideration of the competitiveness (RCA, MCA) of the partner country of negotiations; 2) the tariff protection index of previous FTAs and the import dependence rate of the FTA partner country; and 3) the amount of domestic production. The results of this study indicated that rice, barley, sweet potato, mung bean, red bean, beef, and honey are expected to be major sensitive products, while potato, corn, and pork are expected to be less sensitive in RCEP negotiations. These results are interesting because barley, sweet potato, mung bean, red bean, honey should be less sensitive products than pork and duck based on the amount of domestic production. However, the former items should be more sensitive products in RCEP negotiations than the items with a high amount of domestic production based on the consideration of partner country’s competitiveness and potential ripple effects associated with the previous FTAs.
New Nurses in Reproductive Health: Competency in Providing Trans*-Affirming Patient Care
Creators: name: Beth Mann
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Patients who identify outside of the gender binary (trans* people) are more likely to face discrimination than their cisgender counterparts and often delay or avoid necessary healthcare as a result. While research has assessed strategies to provide general trans*-affirming care, there has been little examination of the role of the nurse, and in particular, how trans*-specific education can help to prepare nurses working in sexual and reproductive health (SRH) to provide affirming care to this growing patient population. This study examines self-reported knowledge and competency among newly licensed Registered Nurses (RN) working in SRH after an educational intervention to teach trans*affirming care principles.
Developmental and degenerative features in a complicated spastic paraplegia
Creators: name: Al Saffar, Muna
name: Barry, Brenda J.
name: Rajab, Anna
name: Mochida, Ganeshwaran H.
name: Nasir, Ramzi
name: Partlow, Jennifer N.
name: Maynard, Thomas M.
name: Walsh, Christopher A.
name: Tan, Wen-Hann
name: LaMantia, Anthony-Samuel
name: Manzini, M. Chiara
name: Hill, R. Sean
name: Gleason, Danielle
name: Vernon, Mike
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: ObjectiveWe sought to explore the genetic and molecular causes of Troyer syndrome, one of several complicated hereditary spastic paraplegias (HSPs). Troyer syndrome had been thought to be restricted to the Amish; however, we identified 2 Omani families with HSP, short stature, dysarthria and developmental delay—core features of Troyer syndrome—and a novel mutation in the SPG20 gene, which is also mutated in the Amish. In addition, we analyzed SPG20 expression throughout development to infer how disruption of this gene might generate the constellation of developmental and degenerative Troyer syndrome phenotypes.MethodsClinical characterization of 2 non-Amish families with Troyer syndrome was followed by linkage and sequencing analysis. Quantitative polymerase chain reaction and in situ hybridization analysis of SPG20 expression were carried out in embryonic and adult human and mouse tissue.ResultsTwo Omani families carrying a novel SPG20 mutation displayed clinical features remarkably similar to the Amish patients with Troyer syndrome. SPG20 mRNA is expressed broadly but at low relative levels in the adult brain; however, it is robustly and specifically expressed in the limbs, face, and brain during early morphogenesis.InterpretationNull mutations in SPG20 cause Troyer syndrome, a specific clinical entity with developmental and degenerative features. Maximal expression of SPG20 in the limb buds and forebrain during embryogenesis may explain the developmental origin of the skeletal and cognitive defects observed in this disorder. ANN NEUROL 2010;67:516–525
MOESM9 of Characterization of the non-glandular gastric region microbiota in Helicobacter suis-infected versus non-infected pigs identifies a potential role for Fusobacterium gastrosuis in gastric ulceration
Creators: name: ChloĂŤ De Witte
name: Demeyere, Kristel
name: Bruyckere, Sofie De
name: Taminiau, Bernard
name: Daube, Georges
name: Ducatelle, Richard
name: Meyer, Evelyne
name: Haesebrouck, Freddy
Publisher: name: Figshare
Year: 2019
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 9. General overview of gene expression analysis of markers for inflammation and ulceration in the Pars oesophagea of H. suis-negative and -positive pigs. The data are presented as fold changes in gene expression normalized to 3 reference genes and relative to a H. suis-negative control pigs. The fold changes are shown as means with the standard error of the mean. Statistical differences were calculated using the non-parametric Kruskal-Wallis H test. *, p < 0.05; significant differences between the H. suis-positive pigs and -negative pigs.
Racial/Ethnic Disparities in Unmet Need for Postpartum Contraception in the United States: Evidence from the Pregnancy Risk Assessment Monitoring System, 2016-2019
Creators: name: Protti, Amanda
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Purpose: Unintended pregnancy and short interpregnancy intervals are associated with adverse maternal and child health outcomes. This study describes the prevalence of unmet need for postpartum contraception and evaluates the relationship between race/ethnicity and unmet need for postpartum contraception in the United States.
Methods: This is a population-based, cross-sectional study using data collected from a stratified random sample of postpartum women by the Pregnancy Risk Assessment Monitoring System, 2016-2019. Descriptive statistics were used to describe respondent characteristics and to estimate the prevalence of unmet need for postpartum contraception. Logistic regression was used to describe the association between unmet need for postpartum contraception and race/ethnicity. Adjusted odds ratios were calculated by controlling for confounders selected based on evidence from the literature in order to more accurately estimate the isolated effect of race/ethnicity on unmet need for contraception.
Results: The overall prevalence of unmet need for postpartum contraception was 10.1%. American Indian and Alaska Native (8.6%) and Hispanic (9.0%) women had the lowest prevalence of unmet need. Women who identified as other race (16.6%), Asian (12.4%), and Black (11.9%) had the highest prevalence of unmet need. After adjusting for confounders, only Black (aOR:1.47; 95% CI: 1.20-1.80), Asian (aOR:1.87; 95% CI: 1.34-2.63), and women who described themselves as other race (aOR: 2.86; 95% CI: 1.19-6.93) had statistically higher odds of unmet need compared to Hispanic women. 
Conclusion: There are significant racial/ethnic disparities in unmet need for postpartum contraception in the United States. There is a need for client-centered postpartum contraception interventions.
Key words: postpartum contraception, race, disparities, family planning, unmet need
Representations of $*$-semigroups associated to invariant kernels with values adjointable operators. I
Creators: name: Ay, Serdar
name: Gheondea, Aurelian
Publisher: name: arXiv
Year: 2015
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: Primary 47A20, Secondary 43A35, 46E22, 46L89

description: We consider positive semidefinite kernels valued in the $*$-algebra of adjointable operators on a VE-space (Vector Euclidean space) and that are invariant under actions of $*$-semigroups. A rather general dilation theorem is stated and proved: for these kind of kernels, representations of the $*$-semigroup on either the VE-spaces of linearisation of the kernels or on their reproducing kernel VE-spaces are obtainable. We point out the reproducing kernel fabric of dilation theory and we show that the general theorem unifies many dilation results at the non topological level.
description: 23 pages
MOESM1 of Understanding xylose isomerase from Burkholderia cenocepacia: insights into structure and functionality for ethanol production
Creators: name: Vieira, Igor
name: Cordeiro, Gabrielle
name: Gomes, Diego
name: Melani, Rafael
name: Vilela, Leonardo
name: Domont, Gilberto
name: Mesquita, Rafael
name: Eleutherio, Elis
name: Neves, Bianca
Publisher: name: Figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology

description: Additional file 1. Additional figures.
Indications of a non-trivial vacuum in the effective theory of perfect fluids
Creators: name: Burch, Tommy
name: Torrieri, Giorgio
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Theory (hep-th)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Using lattice field theory techniques, we investigate the vacuum structure of the field theory corresponding to perfect fluid dynamics in the Lagrangian prescription. We find intriguing, but inconclusive evidence, that the vacuum of such a theory is non-trivial, casting doubts on whether the gradient expansion can provide a good effective field theory for this type of system. The non-trivial vacuum looks like a "turbulent" state where some of the entropy is carried by macroscopic degrees of freedom. We describe further steps to strengthen or falsify this evidence.
description: Version accepted for publication, Phys.Rev.D
Genome-wide association studies of cerebral white matter lesion burden: The CHARGE consortium
Creators: name: Bis, Joshua C.
name: Vernooij, Meike W.
name: Beiser, Alexa
name: Fornage, Myriam
name: Schmidt, Helena
name: Dufouil, Carole
name: Heiss, Gerardo
name: Sigurdsson, Sigurdur
name: Shibata, Dean K.
name: Maillard, Pauline
name: Petrovic, Katja
name: Glazer, Nicole L.
name: Zijdenbos, Alex
name: Niessen, Wiro J.
name: de Boer, Renske
name: Enzinger, Christian
name: Mazoyer, Bernard
name: Cushman, Mary
name: Harris, Tamara B.
name: Cavalieri, Margherita
name: Smith, Albert V.
name: Ikram, M. Arfan
name: Lambert, Jean-Charles
name: Lopez, Oscar L.
name: Debette, Stephanie
name: Knopman, David S.
name: DeStefano, Anita L.
name: Fazekas, Franz
name: Vrooman, Henri A.
name: Gudnason, Haukur
name: Au, Rhoda
name: Lumley, Thomas
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: White matter hyperintensities (WMH) detectable by magnetic resonance imaging (MRI)are part of the spectrum of vascular injury associated with aging of the brain and are thought to reflect ischemic damage to the small deep cerebral vessels. WMH are associated with an increased risk of cognitive and motor dysfunction, dementia, depression, and stroke. Despite a significant heritability, few genetic loci influencing WMH burden have been identified.
Additional file 1 of Decomposition and nutrient release patterns of municipal solid waste compost in two agro-ecological zones of Uganda
Creators: name: Kabasiita, Juliet Kiiza
name: Opolot, Emmanuel
name: Sande, Eric
name: Malinga, Geoffrey Maxwell
Publisher: name: figshare
Year: 2022
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file1: Figure S1 Rainfall and temperature of the study sites.
Star products on graded manifolds and $α'$-corrections to Courant algebroids from string theory
Creators: name: Deser, Andreas
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: Quantum Algebra (math.QA)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: Deformation theory refers to an apparatus in many parts of math and physics for going from an infinitesimal (= first order) deformation to a full deformation, either formal or convergent appropriately. If the algebra being deformed is that of observables, the result is deformation quantization, independent of any realization in terms of Hilbert space operators. There are very important but rare cases in which a formula for a full deformation is known. For physics, the most important is the Moyal-Weyl star product formula. In this paper, we concentrate on deformations of Courant algebroid structures via star products on graded manifolds. In particular, we construct a graded version of the Moyal-Weyl star product. Recently, in Double Field Theory (DFT), deformations of the C-bracket and O(d,d)-invariant bilinear form to first order in the closed string sigma model coupling $α'$ were derived by analyzing the transformation properties of the Neveu-Schwarz B-field. By choosing a particular Poisson structure on the Drinfel'd double corresponding to the Courant algebroid structure of the generalized tangent bundle, we reproduce these deformations for a specific solution of the strong constraint of DFT as expansion of a graded version of the Moyal-Weyl star product.
description: 28 pages, typos corrected, citations added
Trans fat, aspirin, and ischemic stroke in postmenopausal women
Creators: name: Wassertheil-Smoller, Sylvia
name: He, Ka
name: Yaemsiri, Sirin
name: Tinker, Lesley
name: Sen, Souvik
name: Rosamond, Wayne
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: To examine the associations between dietary fat intake and ischemic stroke among postmenopausal women.
A Brief History of Choline
Creators: name: Zeisel, Steven H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: In 1850, Theodore Gobley, working in Paris, described a substance “lecithine”, which he named after the Greek “lekithos” for egg yolk. Adolph Strecker noted in 1862 that when lecithin from bile was heated, it generated a new nitrogenous chemical that he named “choline”. Three years later, Oscar Liebreich identified a new substance, “neurine”, in the brain. After a period of confusion, neurine and choline were found to be the same molecule, and the name choline was adapted. Lecithin was eventually characterized chemically as being phosphatidylcholine. In 1954, Eugene Kennedy described the cytidine 5-dihphosphocholine pathway by which choline is incorporated into phosphatidylcholine. A second route, the phosphatidylethanolamine-N-methyltransferase pathway, was identified by Jon Bremer and David Greenberg in 1960. The role of choline as part of the neurotransmitter acetylcholine was established by Otto Loewi and Henry Dale. Working in the 1930s at the University of Toronto, Charles Best showed that choline prevented fatty liver in dogs and rats. The importance of choline as an essential nutrient for human health was determined in the 1990s through controlled feeding studies in humans. Recently, an understanding of the role of genetic variation in setting the dietary requirement for choline in people is being unraveled.
Dynamic Modeling of Cascading Failure in Power Systems
Creators: name: Song, Jiajia
name: Cotilla-Sanchez, Eduardo
name: Ghanavati, Goodarz
name: Hines, Paul D. H.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Systems and Control (eess.SY)
subject: FOS: Physical sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: The modeling of cascading failure in power systems is difficult because of the many different mechanisms involved; no single model captures all of these mechanisms. Understanding the relative importance of these different mechanisms is an important step in choosing which mechanisms need to be modeled for particular types of cascading failure analysis. This work presents a dynamic simulation model of both power networks and protection systems, which can simulate a wider variety of cascading outage mechanisms, relative to existing quasi-steady state (QSS) models. The model allows one to test the impact of different load models and protections on cascading outage sizes. This paper describes each module of the developed dynamic model and demonstrates how different mechanisms interact. In order to test the model we simulated a batch of randomly selected $N-2$ contingencies for several different static load configurations, and found that the distribution of blackout sizes and event lengths from the proposed dynamic simulator correlates well with historical trends. The results also show that load models have significant impacts on the cascading risks. This dynamic model was also compared against a QSS model based on the dc power flow approximations; we find that the two models largely agree, but produce substantially different results for later stages of cascading.
description: 8 pages, 9 figures, 5 tables, submitted to IEEE transactions
White Rice Intake Varies in Its Association with Metabolic Markers of Diabetes and Dyslipidemia Across Region among Chinese Adults
Creators: name: Gordon-Larsen, Penny
name: Dong, Fei
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: There are inconsistent associations between white rice consumption with diabetes and dyslipidemia, perhaps due to the nature of samples studied and quality of diet data.
Scalar perturbations in cosmological models with dark energy - dark matter interaction
Creators: name: Eingorn, Maxim
name: Kiefer, Claus
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Scalar cosmological perturbations are investigated in the framework of a model with interacting dark energy and dark matter. In addition to these constituents, the inhomogeneous Universe is supposed to be filled with the standard noninteracting constituents corresponding to the conventional $Λ$CDM model. The interaction term is chosen in the form of a linear combination of dark sector energy densities with evolving coefficients. The methods of discrete cosmology are applied, and strong theoretical constraints on the parameters of the model are derived. A brief comparison with observational data is performed.
description: 10 pages, no figures
Hausdorff spectrum of harmonic measure
Creators: name: Tanaka, Ryokichi
Publisher: name: arXiv
Year: 2014
Subjects: subject: Probability (math.PR)
subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 60G50, 20F67, 37F35, 60J50

description: For every non-elementary hyperbolic group, we show that for every random walk with finitely supported admissible step distribution, the associated entropy equals the drift times the logarithmic volume growth if and only if the corresponding harmonic measure is comparable with Hausdorfff measure on the boundary. Moreover, we introduce one parameter family of probability measures which interpolates a Patterson-Sullivan measure and the harmonic measure, and establish a formula of Hausdorff spectrum (multifractal spectrum) of the harmonic measure. We also give some finitary versions of dimensional properties of the harmonic measure.
Comparing Urinary Biomarkers of Airborne and Dermal Exposure to Polycyclic Aromatic Compounds in Asphalt-Exposed Workers
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: When working with hot mix asphalt, road pavers are exposed to polycyclic aromatic hydrocarbons (PAHs) through the inhalation of vapors and particulate matter (PM) and through dermal contact with PM and contaminated surfaces. Several PAHs with four to six rings are potent carcinogens which reside in these particulate emissions. Since urinary biomarkers of large PAHs are rarely detectable in asphalt workers, attention has focused upon urinary levels of the more volatile and abundant two-ring and three-ring PAHs as potential biomarkers of PAH exposure. Here, we compare levels of particulate polycyclic aromatic compounds (P-PACs, a group of aromatic hydrocarbons containing PAHs and heterocyclic compounds with four or more rings) in air and dermal patch samples from 20 road pavers to the corresponding urinary levels of naphthalene (U-Nap) (two rings), phenanthrene (U-Phe) (three rings), monohydroxylated metabolites of naphthalene (OH-Nap) and phenanthrene (OH-Phe), and 1-hydroxypyrene (OH-Pyr) (four rings), the most widely used biomarker of PAH exposure. For each worker, daily breathing-zone air (n = 55) and dermal patch samples (n = 56) were collected on three consecutive workdays along with postshift, bedtime, and morning urine samples (n = 149). Measured levels of P-PACs and the urinary analytes were used to statistically model exposure–biomarker relationships while controlling for urinary creatinine, smoking status, age, body mass index, and the timing of urine sampling. Levels of OH-Phe in urine collected postshift, at bedtime, and the following morning were all significantly associated with levels of P-PACs in air and dermal patch samples. For U-Nap, U-Phe, and OH-Pyr, both air and dermal patch measurements of P-PACs were significant predictors of postshift urine levels, and dermal patch measurements were significant predictors of bedtime urine levels (all three analytes) and morning urine levels (U-Nap and OH-Pyr only). Significant effects of creatinine concentration were observed for all analytes, and modest effects of smoking status and body mass index were observed for U-Phe and OH-Pyr, respectively. Levels of OH-Nap were not associated with P-PAC measurements in air or dermal patch samples but were significantly affected by smoking status, age, day of sample collection, and urinary creatinine. We conclude that U-Nap, U-Phe, OH-Phe, and OH-Pyr can be used as biomarkers of exposure to particulate asphalt emissions, with OH-Phe being the most promising candidate. Indications that levels of U-Nap, U-Phe, and OH-Pyr were significantly associated with dermal patch measurements well into the evening after a given work shift, combined with the small ratios of within-person variance components to between-person variance components at bedtime, suggest that bedtime measurements may be useful for investigating dermal PAH exposures.
Investigation of PAH Biomarkers in the Urine of Workers Exposed to Hot Asphalt
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Airborne emissions from hot asphalt contain mixtures of polycyclic aromatic hydrocarbons (PAHs), including several carcinogens. We investigated urinary biomarkers of three PAHs, namely naphthalene (Nap), phenanthrene (Phe), and pyrene (Pyr) in 20 road-paving workers exposed to hot asphalt and in 6 road milling workers who were not using hot asphalt (reference group). Our analysis included baseline urine samples as well as postshift, bedtime, and morning samples collected over three consecutive days. We measured unmetabolized Nap (U-Nap) and Phe (U-Phe) as well as the monohydroxylated metabolites of Nap (OH-Nap), Phe (OH-Phe), and Pyr (OH-Pyr) in each urine sample. In baseline samples, no significant differences in biomarker levels were observed between pavers and millers, suggesting similar background exposures. In postshift, bedtime, and morning urine samples, the high pairwise correlations observed between levels of all biomarkers suggest common exposure sources. Among pavers, levels of all biomarkers were significantly elevated in postshift samples, indicating rapid uptake and elimination of PAHs following exposure to hot asphalt (biomarker levels were not elevated among millers). Results from linear mixed-effects models of levels of U-Nap, U-Phe, OH-Phe, and OH-Pyr across pavers showed significant effects of work assignments with roller operators having lower biomarker levels than the other workers. However, no work-related effect was observed for levels of OH-Nap, apparently due to the influence of cigarette smoking. Biological half-lives, estimated from regression coefficients for time among pavers, were 8 h for U-Phe, 10 h for U-Nap, 13 h for OH-Phe and OH-Pyr, and 26 h for OH-Nap. These results support the use of U-Nap, U-Phe, OH-Phe, and OH-Pyr, but probably not OH-Nap, as short-term biomarkers of exposure to PAHs emanating from hot asphalt.
Efficacy of the Sterile Insect Technique in the presence of inaccessible areas: A study using two-patch models
Creators: name: Bliman, Pierre-Alexandre
name: Nguyen, Nga
name: Vauchelet, Nicolas
Publisher: name: arXiv
Year: 2024
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: The Sterile Insect Technique (SIT) is one of the sustainable strategies for the control of disease vectors, which consists of releasing sterilized males that will mate with the wild females, resulting in a reduction and, eventually a local elimination, of the wild population. The implementation of the SIT in the field can become problematic when there are inaccessible areas where the release of sterile insects cannot be carried out directly, and the migration of wild insects from these areas to the treated zone may influence the efficacy of this technique. However, we can also take advantage of the movement of sterile individuals to control the wild population in these unreachable places. In this paper, we derive a two-patch model for Aedes mosquitoes where we consider the discrete diffusion between the treated area and the inaccessible zone. We investigate two different release strategies (constant and impulsive periodic releases), and by using the monotonicity of the model, we show that if the number of released sterile males exceeds some threshold, the technique succeeds in driving the whole population in both areas to extinction. This threshold depends on not only the biological parameters of the population but also the diffusion between the two patches.
Quantification and Statistical Modeling—Part I: Breathing-Zone Concentrations of Monomeric and Polymeric 1,6-Hexamethylene Diisocyanate
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: We conducted a repeated exposure-assessment survey for task-based breathing-zone concentrations (BZCs) of monomeric and polymeric 1,6-hexamethylene diisocyanate (HDI) during spray painting on 47 automotive spray painters from North Carolina and Washington State. We report here the use of linear mixed modeling to identify the primary determinants of the measured BZCs. Both one-stage (N = 98 paint tasks) and two-stage (N = 198 paint tasks) filter sampling was used to measure concentrations of HDI, uretidone, biuret, and isocyanurate. The geometric mean (GM) level of isocyanurate (1410 μg m−3) was higher than all other analytes (i.e. GM < 7.85 μg m−3). The mixed models were unique to each analyte and included factors such as analyte-specific paint concentration, airflow in the paint booth, and sampler type. The effect of sampler type was corroborated by side-by-side one- and two-stage personal air sampling (N = 16 paint tasks). According to paired t-tests, significantly higher concentrations of HDI (P = 0.0363) and isocyanurate (P = 0.0035) were measured using one-stage samplers. Marginal R2 statistics were calculated for each model; significant fixed effects were able to describe 25, 52, 54, and 20% of the variability in BZCs of HDI, uretidone, biuret, and isocyanurate, respectively. Mixed models developed in this study characterize the processes governing individual polyisocyanate BZCs. In addition, the mixed models identify ways to reduce polyisocyanate BZCs and, hence, protect painters from potential adverse health effects.
Quantification and Statistical Modeling—Part II: Dermal Concentrations of Monomeric and Polymeric 1,6-Hexamethylene Diisocyanate
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: We conducted a quantitative dermal and inhalation exposure assessment of monomeric and polymeric 1,6-hexamethylene diisocyanates (HDI) in 47 automotive spray painters from North Carolina and Washington State. We report here the use of linear mixed modeling (LMM) to identify the primary determinants of dermal exposure. Dermal concentrations of HDI, uretidone, biuret, and isocyanurate were significantly higher in 15 painters who did not wear coveralls or gloves (N = 51 paint tasks) than in 32 painters who did wear coveralls and gloves (N = 192 paint tasks) during spray painting. Regardless of whether protective clothing was worn, isocyanurate was the predominant species measured in the skin [geometric mean (GM) = 33.8 ng mm−3], with a 95% detection rate. Other polyisocyanates (GM ≤ 0.17 ng mm−3) were detected in skin during <23% of the paint tasks. According to marginal R2 statistics, mixed models generated in this study described no <36% of the variability in dermal concentrations of the different polyisocyanates measured in painters who did not wear protective clothing. These models also described 55% of the variability in dermal concentrations of isocyanurate measured in all painters (N = 288 paint tasks). The product of analyte-specific breathing-zone concentration (BZC) and paint time was the most significant variable in all the models. Through LMM, a better understanding of the exposure pathways governing individual polyisocyanate exposures may be achieved. In particular, we were able to establish a link between BZC and dermal concentration, which may be useful for exposure reconstruction and quantitatively characterizing the protective effect of coveralls and gloves. This information can be used to reduce dermal exposures and better protect automotive spray painters from potential adverse health effects.
Postoperative Delirium (POD) After Hip Fracture Surgery in the Elderly: An Integrative Review of the Literature
Creators: name: Paul, Emily
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Postoperative delirium (POD) is a serious complication that is well-documented in geriatric patients after hip fracture surgery, and the incidence is steadily increasing in the setting of an aging population, bringing with it an increase in POD as well. While POD is a known complication after hip fracture surgery, further exploration in prevention is needed. Early identification of risk factors is imperative to prevent POD in geriatric patients. This study reviews literature from 2012 to 2022 regarding risk factors for POD in geriatric hip fracture patients. Potential modifiable and non-modifiable risk factors for developing POD identified in this review include, but are not limited to, older age, poor cognition (dementia, cognitive impairment, history of delirium), functional impairment, preoperative malnutrition, low albumin, and pain.
Additional file 1 of Comparison of the effects of lidocaine and amiodarone for out-of-hospital cardiac arrest patients with shockable rhythms: a retrospective observational study from a multicenter registry
Creators: name: Kishihara, Yuki
name: Kashiura, Masahiro
name: Amagasa, Shunsuke
name: Fukushima, Fumihito
name: Yasuda, Hideto
name: Moriya, Takashi
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Additional file 1: e-Table 1. STROBE Statement—checklist of items that should be included in reports of observational studies.
Are dark energy models with variable EoS parameter $w$ compatible with the late inhomogeneous Universe?
Creators: name: Akarsu, Ozgur
name: Bouhmadi-López, Mariam
name: Brilenkov, Maxim
name: Brilenkov, Ruslan
name: Eingorn, Maxim
name: Zhuk, Alexander
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We study the late-time evolution of the Universe where dark energy (DE) is presented by a barotropic fluid on top of cold dark matter (CDM). We also take into account the radiation content of the Universe. Here by the late stage of the evolution we refer to the epoch where CDM is already clustered into inhomogeneously distributed discrete structures (galaxies, groups and clusters of galaxies). Under this condition the mechanical approach is an adequate tool to study the Universe deep inside the cell of uniformity. More precisely, we study scalar perturbations of the FLRW metric due to inhomogeneities of CDM as well as fluctuations of radiation and DE. For an arbitrary equation of state for DE we obtain a system of equations for the scalar perturbations within the mechanical approach. First, in the case of a constant DE equation of state parameter $w$, we demonstrate that our method singles out the cosmological constant as the only viable dark energy candidate. Then, we apply our approach to variable equation of state parameters in the form of three different linear parametrizations of $w$, e.g., the Chevallier-Polarski-Linder perfect fluid model. We conclude that all these models are incompatible with the theory of scalar perturbations in the late Universe.
description: 14 pages, no figures
Recensione a FORTUNATO AMMENDOLIA – RICCARDO PETRICCA, Chiesa e pastorale digitale. In uscita verso una società 5.0, Il pozzo di Giacobbe, Trapani 2023
Creators: name: Galati, Antonio
Publisher: name: Istituto Teologico Leoniano di Anagni
Year: 2024

description: Recensione a FORTUNATO AMMENDOLIA – RICCARDO PETRICCA, Chiesa e pastorale digitale. In uscita verso una società 5.0, Il pozzo di Giacobbe, Trapani 2023
MOESM14 of Characterization of the non-glandular gastric region microbiota in Helicobacter suis-infected versus non-infected pigs identifies a potential role for Fusobacterium gastrosuis in gastric ulceration
Creators: name: Chloë De Witte
name: Demeyere, Kristel
name: Bruyckere, Sofie De
name: Taminiau, Bernard
name: Daube, Georges
name: Ducatelle, Richard
name: Meyer, Evelyne
name: Haesebrouck, Freddy
Publisher: name: Figshare
Year: 2019
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Additional file 14. Visualization of MKN-7 cellular morphology using hemacolor staining and detection of early apoptotic and late apoptotic/necrotic cells using flow cytometry. (A-D) Hemacolor staining of MKN-7 cells incubated (A) without F. gastrosuis for 48h and (B-D) with 500 µg F. gastrosuis strain CDW1 incubated for (B) 24 h, (C) 36 h and (D) 48h. Following morphologic features can be seen: plasma membrane blebbing (white arrow), cell swelling (white star), pyknosis (black arrow), cytoplasmic vacuoles (black star). Original magnification x400, scale bar represents 10 µm. (E-L) Representative population plots displaying viable (green, Annexin-V-FITX negative, PI negative), early apoptotic (red, Annexin-V-FITX positive, PI negative), late apoptotic/necrotic (blue, Annexin-V-FITX positive, PI positive) cells of MKN-7 cells incubated (E) without F. gastrosuis lysate for 48 h; (F-H) with 500 µg F. gastrosuis strain CDW1 for (F) 24 h; (G) 36 h and (H) 48 h; (I) without viable F. gastrosuis bacteria for 12h; (J-L) with 50 MOI F. gastrosuis bacteria strain CDW8 for (J) 2h; (K) 6h and (L) 12h. Y-axis: propidium iodide (PE) signal intensity; X-axis: Annexin-V-fluorescein isothiocyanate (FITC) signal intensity. The percentage of population plots is presented in the corresponding gate.
Additional file 2 of Comparison of the effects of lidocaine and amiodarone for out-of-hospital cardiac arrest patients with shockable rhythms: a retrospective observational study from a multicenter registry
Creators: name: Kishihara, Yuki
name: Kashiura, Masahiro
name: Amagasa, Shunsuke
name: Fukushima, Fumihito
name: Yasuda, Hideto
name: Moriya, Takashi
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Additional file 2: e-Table 2. List of ethics committee of participating institutions of Japanese Association for Acute Medicine- out-of-hospital cardiac arrest registry.
Electron-positron pair creation in low-energy collisions of heavy bare nuclei
Creators: name: Maltsev, I. A.
name: Shabaev, V. M.
name: Tupitsyn, I. I.
name: Bondarev, A. I.
name: Kozhedub, Y. S.
name: Plunien, G.
name: Stoehlker, Th.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: A new method for calculations of electron-positron pair-creation probabilities in low-energy heavy-ion collisions is developed. The approach is based on the propagation of all one-electron states via the numerical solving of the time-dependent Dirac equation in the monopole approximation. The electron wave functions are represented as finite sums of basis functions constructed from B-splines using the dual-kinetic-balance technique. The calculations of the created particle numbers and the positron energy spectra are performed for the collisions of bare nuclei at the energies near the Coulomb barrier with the Rutherford trajectory and for different values of the nuclear charge and the impact parameter. To examine the role of the spontaneous pair creation the collisions with a modified velocity and with a time delay are also considered. The obtained results are compared with the previous calculations and the possibility of observation of the spontaneous pair creation is discussed.
description: 16 pages, 6 figures
Quantitative Plasma Biomarker Analysis in HDI Exposure Assessment
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Quantification of amines in biological samples is important for evaluating occupational exposure to diisocyanates. In this study, we describe the quantification of 1,6-hexamethylene diamine (HDA) levels in hydrolyzed plasma of 46 spray painters applying 1,6-hexamethylene diisocyanate (HDI)-containing paint in vehicle repair shops collected during repeated visits to their workplace and their relationship with dermal and inhalation exposure to HDI monomer. HDA was detected in 76% of plasma samples, as heptafluorobutyryl derivatives, and the range of HDA concentrations was ≤0.02–0.92 μg l−1. After log-transformation of the data, the correlation between plasma HDA levels and HDI inhalation exposure measured on the same workday was low (N = 108, r = 0.22, P = 0.026) compared with the correlation between plasma HDA levels and inhalation exposure occurring ∼20 to 60 days before blood collection (N = 29, r = 0.57, P = 0.0014). The correlation between plasma HDA levels and HDI dermal exposure measured on the same workday, although statistically significant, was low (N = 108, r = 0.22, P = 0.040) while the correlation between HDA and dermal exposure occurring ∼20 to 60 days before blood collection was slightly improved (N = 29, r = 0.36, P = 0.053). We evaluated various workplace factors and controls (i.e. location, personal protective equipment use and paint booth type) as modifiers of plasma HDA levels. Workers using a downdraft-ventilated booth had significantly lower plasma HDA levels relative to semi-downdraft and crossdraft booth types (P = 0.0108); this trend was comparable to HDI inhalation and dermal exposure levels stratified by booth type. These findings indicate that HDA concentration in hydrolyzed plasma may be used as a biomarker of cumulative inhalation and dermal exposure to HDI and for investigating the effectiveness of exposure controls in the workplace.