cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Predicting risk for radiographic damage in rheumatoid arthritis: comparative analysis of the multi-biomarker disease activity score and conventional measures of disease activity in multiple studies
Creators: name: Curtis, Jeffrey R.
name: Brahe, Cecilie H.
name: Østergaard, Mikkel
name: Hetland, Merete Lund
name: Hambardzumyan, Karen
name: Saevarsdottir, Saedis
name: Wang, Xingbin
name: Flake, Darl D.
name: Sasso, Eric H.
name: Huizinga, T. W.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Objective: To compare the multi-biomarker disease activity (MBDA) score with the DAS28-CRP and CRP for predicting risk of radiographic progression in patients with rheumatoid arthritis. Methods: Published studies of the MBDA score and radiographic progression with ≥100 patients per cohort were evaluated. Rates of radiographic progression over 1 year were determined across the low/moderate/high categories for MBDA score (low/moderate/high: <30, 30–44, >44), DAS28-CRP (low/moderate/high: ≤2.67, >2.67–4.09, >4.09) and CRP (low/moderate/high: ≤10, >10–30, >30 mg/L), with positive and negative predictive value (PPV, NPV) and relative risk (RR) determined for high vs. not-high (i.e. low and moderate combined) categories. Patient-level data from studies having all three measures was pooled to: (1) determine a combined RR for radiographic progression in the high vs. not-high categories for each measure; and (2) compare the predictive ability of MBDA score vs. DAS28-CRP by comparing the rates of radiographic progression observed in subgroups created by cross-classifying the high and not-high categories of each measure. Results: Five cohorts were identified for inclusion (total N=929). In each, radiographic progression was more frequent with increasing MBDA scores. Among the three cohorts with requisite data, PPVs were generally similar using categories of MBDA score, DAS28-CRP or CRP but NPVs were greater for MBDA score (93–97%) than DAS28-CRP or CRP (77–87%). RRs for radiographic progression were greater when based on categories of MBDA score than DAS28-CRP or CRP and the combined RR was greater for MBDA score (4.6, p < .0001) than DAS28-CRP (1.7, p = .02) or CRP (1.7, p = .002). For patients cross-classified by MBDA score and DAS28-CRP, high vs. not-high MBDA score significantly predicted radiographic progression independently of DAS28-CRP. Conclusions: High and not-high MBDA scores were associated with increased and low risk, respectively, for radiographic progression over one year. MBDA score was a better predictor of radiographic progression than DAS28-CRP or CRP.
title: ADCO, Comptes du Petit-Cîteaux (1477-1491) (11 H 1179), f. 00255
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Archives Départementales De La Côte D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: comptes
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Comptes du Petit-Cîteaux (1477-1491), Archives départementales de la Côte-d'Or, (11 H 1179). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Comptes du Petit-Cîteaux (1477-1491), Archives départementales de la Côte-d'Or, (11 H 1179), f. 00255, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Additional file 7 of What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review
Creators: name: Land, Magnus
name: Wit, Cynthia
name: Bignert, Anders
name: Cousins, Ian
name: Herzke, Dorte
name: Johansson, Jana
name: Martin, Jonathan
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Computational Biology

description: Additional file 7. Reanalysed time trends.
Dynamics of induced homeomorphisms of one-dimensional solenoids
Creators: name: Hernández, Francisco José López
Publisher: name: arXiv
Year: 2017
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 22XX, 37XX

description: We study the displacement function of homeomorphisms isotopic to the identity of the universal one-dimensional solenoid and we get a characterization of the lifting property for an open and dense subgroup of the isotopy component of the identity. The dynamics of an element in this subgroup is also described using rotation theory.
description: 17 pages
MOESM7 of What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review
Creators: name: Land, Magnus
name: Wit, Cynthia
name: Bignert, Anders
name: Cousins, Ian
name: Herzke, Dorte
name: Johansson, Jana
name: Martin, Jonathan
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 7. Reanalysed time trends.
O PAPEL DAS CIÊNCIAS FORENSES NA ELUCIDAÇÃO DE FRAUDES: UMA NOVA FERRAMENTA PROBATÓRIA NO PROCESSO CIVIL BRASILEIRO
Creators: name: Manuella Cássia Peixoto Villa Nova
name: Diogo Severino Ramos da Silva
name: Reginaldo Inojosa Carneiro Campello
name: Adriana Conrado de Almeida
Publisher: name: Zenodo
Year: 2022

description: RESUMO

 

O presente manuscrito tem como foco investigar a relevância da prova pericial no âmbito do processo civil brasileiro, mostrando a importância do perito em casos de complexidade técnica, onde o magistrado utiliza-se do expert pra produzir a prova pericial, resultando na eficácia constitucional da prova, o que possibilita a elucidação do fato através da ciência forense.

 

Palavras-chave: Ciência. Perito. Prova. Assistente Técnico. Código de Processo Civil. Brasil.
Additional file 2: Figure S2. of Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation
Creators: name: Madero-Pérez, Jesús
name: Fdez, Elena
name: Fernández, Belén
name: Ordóñez, Antonio Lara
name: Ramírez, Marian Blanca
name: Gómez-Suaga, Patricia
name: Waschbüsch, Dieter
name: Lobbestael, Evy
name: Baekelandt, Veerle
name: Nairn, Angus
name: Ruiz-Martínez, Javier
name: Aiastui, Ana
name: Munain, Adolfo López De
name: Lis, Pawel
name: Comptdaer, Thomas
name: Jean-Marc Taymans
name: Marie-Christine Chartier-Harlin
name: Beilina, Alexandria
name: Gonnelli, Adriano
name: Cookson, Mark
name: Greggio, Elisa
name: Hilfiker, Sabine
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Pathogenic LRRK2 disturbs centrosome cohesion in a kinase-dependent manner. (DOCX 1155 kb)
Immune durability and protection against SARS-CoV-2 re-infection in Syrian hamsters
Creators: name: Field, C. J.
name: Heinly, T.A.
name: Patel, D. R.
name: Sim, D. G.
name: Luley, E.
name: Gupta, S. L.
name: Vanderford, T. H.
name: Wrammert, J.
name: Sutton, T. C.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology
subject: Computational Biology

description: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused a pandemic. As immunity to endemic human coronaviruses (i.e., NL63 or OC43) wanes leading to re-infection, it was unknown if SARS-CoV-2 immunity would also decline permitting repeat infections. Recent case reports confirm previously infected individuals can become re-infected; however, re-infection may be due to heterogeneity in the initial infection or the host immune response, or may be the result of infection with a variant strain that escapes pre-existing immunity. To control these variables, we utilized the Syrian hamster model to evaluate the duration of immunity and susceptibility to re-infection with SARS-CoV-2. Hamsters were given a primary mock or SARS-CoV-2 infection (culture media or 105 TCID50 USA/WA1/2020 isolate, respectively). Mock and SARS-CoV-2 infected hamsters were then given a secondary SARS-CoV-2 infection at 1, 2, 4, or 6 months post-primary infection (n = 14/time point/group). After the primary SARS-CoV-2 infection, hamsters developed anti-spike protein IgG, IgA, and neutralizing antibodies, and these antibodies were maintained for at least 6 months. Upon secondary SARS-CoV-2 challenge, previously SARS-CoV-2 infected animals were protected from weight loss, while all previously mock infected animals became infected and lost weight. Importantly, despite having high titres of antibodies, one SARS-CoV-2 infected animal re-challenged at 4 months had a breakthrough infection with replicating virus in the upper and lower respiratory tract. These studies demonstrate immunity to SARS-CoV-2 is maintained for 6 months; however, protection may be incomplete and, even in the presence of high antibody titres, previously infected hosts may become re-infected.
title: Style à extrémité en spatule (Inv. 988.7.4637.4) – Oppidum de Bibracte
Creators: name: Bibracte
Publisher: name: Conservatoire National des Données 3D (CND3D)
Year: 2024
Subjects: subject: instrument d'écriture

description: Si les Gaulois avaient la réputation de rejeter l écriture  ils n étaient pas pour autant illettrés. Pour preuve  les stylets découverts à Bibracte. Le stylet  un instrument d écriture généralement en fer ou en os  était utilisé pour graver des inscriptions sur des tablettes de cire. Il permettait aux Gaulois de transcrire leur langue à l aide de l alphabet grec  puis  à partir de la fin du Ier siècle avant notre ère  de l alphabet latin.
O tempo forma o tronco [time forms the trunk]
Creators: name: Da Loba, André
Publisher: name: Zenodo
Year: 2022
Subjects: design education; design graduates

description: This poster was developed based on the number of design graduates in Portugal. The visualisation was commissioned by the team of the DesignOBS project (Towards a Design Observatory in Portugal, www.designobs.pt), following a distributed and participatory approach. The dataset used to create this work is available here: Costa, N., Branco, V., Costa, R., Borges, A., Cunca, R., Modesto, A., & Silva, A.C. (2021). Diplomados em Design em Portugal [design graduates in PT] (2002-2020) (Version 1) [Data set]. Zenodo. https://doi.org/10.5281/zenodo.5728036 Work developed within the project: Design Obs. Towards a Design Observatory: models, instruments, representations and strategies. Supported by the Lisbon Regional Operational Programme (Lisboa 2020) and the Competitiveness and Internationalisation Operational Programme (POCI-01-0145-FEDER-032445), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) and FCT – Foundation for Science and Technology.
Additional file 4: Table S1. of ADMP controls the size of Spemann's organizer through a network of self-regulating expansion-restriction signals
Creators: name: Leibovich, Avi
name: Kot-Leibovich, Hadas
name: Ben-Zvi, Danny
name: Fainsod, Abraham
Publisher: name: figshare
Year: 2018
Subjects: subject: Molecular Biology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Primers used for cloning. (PDF 21 kb)
Experimental Synthetic Aperture Radar with Dynamic Metasurfaces
Creators: name: Sleasman, Timothy
name: Boyarsky, Michael
name: Pulido-Mancera, Laura
name: Fromenteze, Thomas
name: Imani, Mohammadreza F.
name: Reynolds, Matthew
name: Smith, David R.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Classical Physics (physics.class-ph)
subject: FOS: Physical sciences

description: We investigate the use of a dynamic metasurface as the transmitting antenna for a synthetic aperture radar (SAR) imaging system. The dynamic metasurface consists of a one-dimensional microstrip waveguide with complementary electric resonator (cELC) elements patterned into the upper conductor. Integrated into each of the cELCs are two diodes that can be used to shift each cELC resonance out of band with an applied voltage. The aperture is designed to operate at K band frequencies (17.5 to 20.3 GHz), with a bandwidth of 2.8 GHz. We experimentally demonstrate imaging with a fabricated metasurface aperture using existing SAR modalities, showing image quality comparable to traditional antennas. The agility of this aperture allows it to operate in spotlight and stripmap SAR modes, as well as in a third modality inspired by computational imaging strategies. We describe its operation in detail, demonstrate high-quality imaging in both 2D and 3D, and examine various trade-offs governing the integration of dynamic metasurfaces in future SAR imaging platforms.
Radio and optical intra-day variability observations of five blazars
Creators: name: Liu, X.
name: Yang, P. P.
name: Liu, J.
name: Liu, B. R.
name: Hu, S. M.
name: Kurtanidze, O. M.
name: Zola, S.
name: Kraus, A.
name: Krichbaum, T. P.
name: Su, R. Z.
name: Gazeas, K.
name: Sadakane, K.
name: Nilson, K.
name: Reichart, D. E.
name: Kidger, M.
name: Matsumoto, K.
name: Okano, S.
name: Siwak, M.
name: Webb, J. R.
name: Pursimo, T.
name: Garcia, F.
name: Nogues, R. Naves
name: Erdem, A.
name: Alicavus, F.
name: Balonek, T.
name: Jorstad, S. G.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We carried out a pilot campaign of radio and optical band intra-day variability (IDV) observations of five blazars (3C66A, S5 0716+714, OJ287, B0925+504, and BL Lacertae) on December 18--21, 2015 by using the radio telescope in Effelsberg (Germany) and several optical telescopes in Asia, Europe, and America. After calibration, the light curves from both 5 GHz radio band and the optical R band were obtained, although the data were not smoothly sampled over the sampling period of about four days. We tentatively analyse the amplitudes and time scales of the variabilities, and any possible periodicity. The blazars vary significantly in the radio (except 3C66A and BL Lacertae with only marginal variations) and optical bands on intra- and inter-day time scales, and the source B0925+504 exhibits a strong quasi-periodic radio variability. No significant correlation between the radio- and optical-band variability appears in the five sources, which we attribute to the radio IDV being dominated by interstellar scintillation whereas the optical variability comes from the source itself. However, the radio- and optical-band variations appear to be weakly correlated in some sources and should be investigated based on well-sampled data from future observations.
description: 6 pages, 6 figures, accepted by MNRAS
Time-multiplexed structured illumination using a DMD for optical diffraction tomography
Creators: name: Lee, Kyeoreh
name: Kim, Kyoohyun
name: Kim, Geon
name: Shin, Seungwoo
name: Park, YongKeun
Publisher: name: arXiv
Year: 2016
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We present a novel illumination control technique for optical diffraction tomography (ODT). Various spatial frequencies of beam illumination were controlled by displaying time-averaged sinusoidal patterns using a digital micromirror device (DMD). Compared to the previous method using binary Lee holograms, the present method eliminates unwanted diffracted beams which may deteriorate the image quality of the ODT. We demonstrated the capability of the present method by reconstructing three-dimensional refractive index (RI) distributions of various samples, with high RI sensitivity (σ_Δn = 3.15 +/- 10-4), and reconstructing 3-D RI tomograms of biological samples, which provided quantitative biochemical and morphological information about the samples.
Predicting risk for radiographic damage in rheumatoid arthritis: comparative analysis of the multi-biomarker disease activity score and conventional measures of disease activity in multiple studies
Creators: name: R. Curtis, Jeffrey
name: Brahe, Cecilie H.
name: Østergaard, Mikkel
name: Lund Hetland, Merete
name: Hambardzumyan, Karen
name: Saevarsdottir, Saedis
name: Wang, Xingbin
name: Flake, Darl D.
name: Sasso, Eric H.
name: Huizinga, T. W.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Objective: To compare the multi-biomarker disease activity (MBDA) score with the DAS28-CRP and CRP for predicting risk of radiographic progression in patients with rheumatoid arthritis. Methods: Published studies of the MBDA score and radiographic progression with ≥100 patients per cohort were evaluated. Rates of radiographic progression over 1 year were determined across the low/moderate/high categories for MBDA score (low/moderate/high: <30, 30–44, >44), DAS28-CRP (low/moderate/high: ≤2.67, >2.67–4.09, >4.09) and CRP (low/moderate/high: ≤10, >10–30, >30 mg/L), with positive and negative predictive value (PPV, NPV) and relative risk (RR) determined for high vs. not-high (i.e. low and moderate combined) categories. Patient-level data from studies having all three measures was pooled to: (1) determine a combined RR for radiographic progression in the high vs. not-high categories for each measure; and (2) compare the predictive ability of MBDA score vs. DAS28-CRP by comparing the rates of radiographic progression observed in subgroups created by cross-classifying the high and not-high categories of each measure. Results: Five cohorts were identified for inclusion (total N=929). In each, radiographic progression was more frequent with increasing MBDA scores. Among the three cohorts with requisite data, PPVs were generally similar using categories of MBDA score, DAS28-CRP or CRP but NPVs were greater for MBDA score (93–97%) than DAS28-CRP or CRP (77–87%). RRs for radiographic progression were greater when based on categories of MBDA score than DAS28-CRP or CRP and the combined RR was greater for MBDA score (4.6, p < .0001) than DAS28-CRP (1.7, p = .02) or CRP (1.7, p = .002). For patients cross-classified by MBDA score and DAS28-CRP, high vs. not-high MBDA score significantly predicted radiographic progression independently of DAS28-CRP. Conclusions: High and not-high MBDA scores were associated with increased and low risk, respectively, for radiographic progression over one year. MBDA score was a better predictor of radiographic progression than DAS28-CRP or CRP.
Additional file 3: of Study on the persistence of Zika virus (ZIKV) in body fluids of patients with ZIKV infection in Brazil
Creators: name: Calvet, Guilherme
name: Kara, Edna
name: Giozza, Silvana
name: Bôtto-Menezes, Camila
name: Gaillard, Philippe
name: Franca, Rafael De Oliveira
name: Lacerda, Marcus De
name: Castilho, Marcia Da Costa
name: Brasil, Patrícia
name: Sequeira, Patrícia De
name: Mello, Maeve De
name: Bermudez, Ximena
name: Kayvon Modjarrad
name: Meurant, Robyn
name: Sihem Landoulsi
name: Benzaken, Adele
name: Filippis, Ana De
name: Broutet, Nathalie
Publisher: name: figshare
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Questionnaire_enrolment_male. (PDF 444 kb)
A autobiografia do doutor Nunes Garcia Junior
Creators: name: GARCIA JR; CAMILO, Vandelir
Publisher: name: Zenodo
Year: 2022
Subjects: José Mauricio Nunes Garcia Junior; Necromemória; Memória Social

description: A autobiografia foi organizada por Vandelir Camilo e cobre os anos de 1808 até 1860 da trajetoria desse médico
Additional file 1 of Synthesis of DOTA-pyridine chelates for 64Cu coordination and radiolabeling of αMSH peptide
Creators: name: Yang, Hua
name: Gao, Feng
name: McNeil, Brooke
name: Zhang, Chengcheng
name: Yuan, Zheliang
name: Zeisler, Stefan
name: Kumlin, Joel
name: Zeisler, Jutta
name: Bénard, François
name: Ramogida, Caterina
name: Schaffer, Paul
Publisher: name: figshare
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health
subject: Computational Biology

description: Additional file 1.
title: ADCO, Comptes du Petit-Cîteaux (1477-1491) (11 H 1179), f. 00596
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: comptes
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Comptes du Petit-Cîteaux (1477-1491), Archives départementales de la Côte-d'Or, (11 H 1179). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Comptes du Petit-Cîteaux (1477-1491), Archives départementales de la Côte-d'Or, (11 H 1179), f. 00596, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Patient-reported outcomes from a randomized, crossover trial comparing a pen injector with insulin degludec versus a pen injector with insulin glargine U100 in patients with type 2 diabetes
Creators: name: Warren, Mark L.
name: Brod, Meryl
name: Håkan-Bloch, Jonas
name: Sparre, Thomas
name: Chaykin, Louis B.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Objective: Type 2 diabetes (T2D) is associated with insulin resistance and deteriorated glycemic control that can be restored with insulin injections. Choice of insulin pen injector may affect complexity, adherence, efficacy of treatment and health-related quality of life. We describe detailed patient-reported outcomes (PROs) on treatment impact and preference comparing insulin degludec (degludec) using FlexTouch1 versus insulin glargine U100 (glargine U100) with SoloStar2 pen injector. Methods: In this randomized, multicenter (USA), open-label, crossover, treat-to-target study (NCT01570751), patients with T2D using high-dose insulin (≥81 U/day from vials) were randomized (n = 145) 1:1 to 16 weeks of degludec U200 (3 mL FlexTouch) followed by 16 weeks of glargine U100 (3 mL SoloStar) or vice versa. PRO questionnaires assessed treatment impact and patient preference of pen injectors. Results: Significantly more patients (p < .01) considered FlexTouch “extremely easy” for learning (62.5 vs. 43.0%), maintaining (63.2 vs. 42.2%) and adjusting the dose (63.2 vs. 44.4%), and significantly more were “very” or “extremely confident” in using the device (60.3 vs. 36.3%) and in its accuracy (50.7 vs. 30.4%) versus SoloStar. Significantly more were “not at all bothered” by device discomfort (74.3 vs. 54.1%), whereas device size (83.8 vs. 80.0%) or public use (69.9 vs. 60.7%) were numerically in favor of FlexTouch. Significantly more patients preferred degludec treatment with FlexTouch (59 vs. 22%), preferred to continue (67 vs. 15%) and recommend (67 vs. 14%) use of FlexTouch compared with SoloStar with glargine U100. Conclusions: In this randomized, crossover trial, lower treatment impact and higher patient preference were reported for FlexTouch versus SoloStar pen injectors.
Supergravity on the noncommutative geometry
Creators: name: Shimojo, Masafumi
name: Ishihara, Satoshi
name: Kataoka, Hironobu
name: Matsukawa, Atsuko
name: Sato, Hikaru
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Two years ago, we found the supersymmetric counterpart of the spectral triple which specified noncommutative geometry. Based on the triple, we derived gauge vector supermultiplets, Higgs supermultiplets of the minimum supersymmetric standard model and its action. However, unlike the famous theories of Connes and his co-workers, the action does not couple to gravity. In this paper, we obtain the supersymmetric Dirac operator $\mathcal{D}_M^{(SG)}$ on the Riemann-Cartan curved space replacing derivatives which appear in that of the triple with the covariant derivatives of general coordinate transformation. We apply the supersymmetric version of the spectral action principle and investigate the heat kernel expansion on the square of the Dirac operator. As a result, we obtain a new supergravity action which does not include the Ricci curvature tensor.
description: to be published in "Progress of Theoretical and Experimental Physics"
Additional file 1: Figure S1. of Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation
Creators: name: Madero-Pérez, Jesús
name: Fdez, Elena
name: Fernández, Belén
name: Ordóñez, Antonio Lara
name: Ramírez, Marian Blanca
name: Gómez-Suaga, Patricia
name: Waschbüsch, Dieter
name: Lobbestael, Evy
name: Baekelandt, Veerle
name: Nairn, Angus
name: Ruiz-Martínez, Javier
name: Aiastui, Ana
name: Munain, Adolfo López De
name: Lis, Pawel
name: Comptdaer, Thomas
name: Jean-Marc Taymans
name: Marie-Christine Chartier-Harlin
name: Beilina, Alexandria
name: Gonnelli, Adriano
name: Cookson, Mark
name: Greggio, Elisa
name: Hilfiker, Sabine
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Distinct pathogenic LRRK2 mutants cause deficits in centrosome cohesion in transfected HEK293T cells. (DOCX 1160 kb)
Additional file 3: Figure S2. of ADMP controls the size of Spemann's organizer through a network of self-regulating expansion-restriction signals
Creators: name: Leibovich, Avi
name: Kot-Leibovich, Hadas
name: Ben-Zvi, Danny
name: Fainsod, Abraham
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Robustness of the organizer induction domain to several parameters, and dynamics of elements in the model. (A–C) Heat maps for ALK2 occupancy (A), ALK1 occupancy (B), and levels of ADMP (C). X axis denotes position along the dorsoventral axis, Y axis denotes time, tsteady is the time when steady state organizer induction is achieved in the dual receptor model. Note that despite the finding that the organizer induction domain is in steady state, ALK1 and ALK2 occupancy, as well as levels of ADMP, are not in steady state. (D–F) Robustness of the organizer induction domain with respect to the ADMP-ALK2 binding rate (D), ADMP-ALK1 binding rate (E), and receptor recycling rate (F). Organizer domain is relative to its size in the reference data set. In the reference data set, ADMP-ALK2 and ADMP-ALK1 binding rate are 0.1 nM–1 s–1, and receptor recycling rate is 10–3 s–1. (PDF 432 kb)
Ubiquity of Unconventional Phenomena Associated with Critical Valence Fluctuations in Heavy Fermion Metals
Creators: name: Miyake, K.
name: Watanabe, S.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Ubiquity of unconventional phenomena observed in a series of heavy fermion metals is discussed on the basis of an idea of critical valence fluctuations. After surveying experimental aspects of these unconventional behaviors in prototypical compounds, CeCu_2(Si,Ge)_2, under pressure, we propose that sharp valence crossover phenomena are realized in CeCu_6, CeRhIn_5, and Ce(Ir,Rh)Si_3 by tuning the pressure and the magnetic field simultaneously, on the basis of previous results for an extended Anderson lattice model with the Coulomb repulsion U_fc between localized f-electron and itinerant conduction electrons.
description: 21 pages, 10 figures, Invited Paper at SCES2016, to appear in Philosophical Magazine
On the stellar masses of giant clumps in distant star-forming galaxies
Creators: name: Dessauges-Zavadsky, Miroslava
name: Schaerer, Daniel
name: Cava, Antonio
name: Mayer, Lucio
name: Tamburello, Valentina
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We analyse stellar masses of clumps drawn from a compilation of star-forming galaxies at 1.1
description: 8 pages, 3 figures, ApJL accepted
Additional file 4: Table S1. of Psychotropic medication non-adherence and associated factors among adult patients with major psychiatric disorders: a protocol for a systematic review
Creators: name: Agumasie Semahegn
name: Kwasi Torpey
name: Abubakar Manu
name: Nega Assefa
name: Gezahegn Tesfaye
name: Ankomah, Augustine
Publisher: name: figshare
Year: 2018
Subjects: subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Studies description form. (DOCX 16 kb)
Molecular docking and multivariate analysis studies of active compounds in the safflower injection
Creators: name: Fan, Jianxin
name: Qin, Xuemei
name: Li, Zhenyu
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: Safflower injection (SI) is a herbal injection made from the dried flower of Carthamus tinctorius L. SI is mainly used for the treatment of cerebral infarction, coronary heart disease, and other diseases. However, the active compounds responsible for the bioactivity of the SI remain unknown. In this study, a total of 46 compounds were identified in the SI by the ultra-high-performance liquid chromatography-Q Exactive hybrid quadrupole-orbitrap high-resolution accurate mass spectrometry, and the molecular docking analysis showed that six compounds were probably served as the key components for the therapeutic effect of the SI against cerebral ischemia and coronary heart disease. Although the active compounds for the two diseases were same, the corresponding targets were different. The obtained results were useful for the quality control and the explanation of the pharmacological mechanism of the SI. The docking data were further subjected to the multivariate analysis, and the result showed that the active compounds were clustered together in the scatter plot, and the key targets could be determined by the VIP scores. Thus, the multivariate analysis could be used as a useful method to screen the active compounds and targets efficiently based on the docking data sets.
Patient-reported outcomes (PRO) from a randomized, crossover trial comparing insulin degludec using FlexTouch® with insulin glargine U100 using SoloSTAR® pen-injectors in patients with type 2 diabetes
Creators: name: Warren, Mark L.
name: Brod, Meryl
name: Håkan-Bloch, Jonas
name: Sparre, Thomas
name: Chaykin, Louis B.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Objective: Type 2 diabetes (T2D) is associated with insulin resistance and deteriorated glycemic control that can be restored with insulin injections. Choice of insulin pen-injector may affect complexity, adherence, efficacy of treatment and health-related quality of life. We describe detailed patient-reported outcomes (PROs) on treatment impact and preference comparing insulin degludec (degludec) using FlexTouch® versus insulin glargine U100 (glargine U100) with SoloSTAR® pen-injector. Methods: In this randomized, multicenter (USA), open-label, crossover, treat-to-target study (NCT01570751), patients with T2D using high-dose insulin (≥81 U/day from vials) were randomized (n = 145) 1:1 to 16 weeks of degludec U200 (3 mL FlexTouch®) followed by 16 weeks of glargine U100 (3 mL SoloSTAR®) or vice versa. PRO questionnaires assessed treatment impact and patient preference of pen-injectors. Results: Significantly more patients (p < 0.01) considered FlexTouch® ‘extremely easy’ for learning (62.5 vs. 43.0%), maintaining (63.2 vs. 42.2%), and adjusting the dose (63.2 vs. 44.4%), and significantly more were ‘very or extremely confident’ using the device (60.3 vs. 36.3%) and in its accuracy (50.7 vs. 30.4%) versus SoloSTAR®. Significantly more were ‘not at all bothered’ by device discomfort (74.3 vs. 54.1%), whereas device size (83.8 vs. 80.0%) or public use (69.9 vs. 60.7%) were numerically in favor of FlexTouch®. Significantly more patients preferred degludec treatment with FlexTouch® (59 vs. 22%), preferred to continue (67 vs. 15%) and recommend (67 vs. 14%) use of FlexTouch® compared with SoloSTAR® with glargine U100. Conclusions: In this randomized, crossover trial, lower treatment impact and higher patient preference were reported for FlexTouch® versus SoloSTAR® pen-injectors.
WISH-OI Proposal, Hop on to OCEAN:ICE Water-Ice-Snow
Creators: name: Dykyi, Evgeny
name: Marushevska, Olena
Publisher: name: Zenodo
Year: 2024

description: Evgeny Dykyi and Olena Marushevska from National Antarctic Scientific Centre delivered a presentation on ‘WISH-OI, Hop on OCEAN:ICE: Water - Ice - Snow’.

This presentation was given at the SO-CHIC and OCEAN:ICE Joint Project Conference on the 25th of October 2023.
Physically unclonable function using initial waveform of ring oscillators on 65 nm CMOS technology
Creators: name: Tanamoto, Tetsufumi
name: Takaya, Satoshi
name: Sakamoto, Nobuaki
name: Kasho, Hirotsugu
name: Yasuda, Shinichi
name: Marukame, Takao
name: Fujita, Shinobu
name: Mitani, Yuichiro
Publisher: name: arXiv
Year: 2017
Subjects: subject: Cryptography and Security (cs.CR)
subject: Hardware Architecture (cs.AR)
subject: FOS: Computer and information sciences

description: A silicon physically unclonable function (PUF) using ring oscillators (ROs) has the advantage of easy application in both an application specific integrated circuit (ASIC) and a field-programmable gate array (FPGA). Here, we provide a RO-PUF using the initial waveform of the ROs based on 65 nm CMOS technology. Compared with the conventional RO-PUF, the number of ROs is greatly reduced and the time needed to generate an ID is within a couple of system clocks.
description: 5 pages, 9 figures
Additional file 2: of Study on the persistence of Zika virus (ZIKV) in body fluids of patients with ZIKV infection in Brazil
Creators: name: Calvet, Guilherme
name: Kara, Edna
name: Giozza, Silvana
name: Bôtto-Menezes, Camila
name: Gaillard, Philippe
name: Franca, Rafael De Oliveira
name: Lacerda, Marcus De
name: Castilho, Marcia Da Costa
name: Brasil, Patrícia
name: Sequeira, Patrícia De
name: Mello, Maeve De
name: Bermudez, Ximena
name: Kayvon Modjarrad
name: Meurant, Robyn
name: Sihem Landoulsi
name: Benzaken, Adele
name: Filippis, Ana De
name: Broutet, Nathalie
Publisher: name: figshare
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Questionnaire_enrolment_female. (PDF 460 kb)
Scintillation and irregularities from the nightside part of a Sun-aligned polar cap arc
Creators: name: van der Meeren, Christer
name: Oksavik, Kjellmar
name: Lorentzen, Dag A.
name: Paxton, Larry J.
name: Clausen, Lasse B. N.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: In this paper we study the presence of irregularities and scintillation in relation to the nightside part of a long-lived, Sun-aligned transpolar arc on 15 January 2015. The arc was observed in DMSP UV and particle data and lasted at least 3 h between 1700 and 2000 UT. The arc was more intense than the main oval during this time. From all-sky imagers on Svalbard we were able to study the evolution of the arc, which drifted slowly westward toward the dusk cell. The intensity of the arc as observed from ground was 10-17 kR in 557.7 nm and 2-3.5 kR in 630.0 nm, i.e., significant emissions in both green and red emission lines. We have used high-resolution raw data from global navigation satellite systems (GNSS) receivers and backscatter from Super Dual Auroral Radar Network (SuperDARN) radars to study irregularities and scintillation in relation to the polar cap arc. Even though the literature has suggested that polar cap arcs are potential sources for irregularities, our results indicate only very weak irregularities. This may be due to the background density in the northward IMF polar cap being too low for significant irregularities to be created.
Conoscenza e felicità nell’etica socratico-platonica
Creators: name: Trabattoni, Franco
Publisher: name: Thaumàzein | Rivista di Filosofia
Year: 2022

description: Knowledge and happiness in Socratic-Platonic ethics: the case of Hippias Minor This essay is based on the assumption that ancient philosophy is still interesting for us as much as we get rid of modern prejudices and are willing to take into consideration opinions considerably different from the most widespread modern ideas. The objects of the inquiry are the so-called paradoxes of Socratic-Platonic ethics (virtue is knowledge, vice is ignorance, no one does evil voluntarily), all in various ways dependent on the fact that Plato believed that ethics was a technique. The first part of the article sets out the general reasons why Plato maintained such identification. The second part takes into consideration the Hippias Minor (in particular the last pages), namely the dialogue in which, according to some interpreters, Plato intends to show that ethics cannot be reduced to a technique. The author aims to show that this hypothesis is incorrect: what Plato is doing with this dialogue is, in fact, to prove that the differences between ethics and other techniques do not prejudice the fact that ethics too is a technique.
description: Thaumàzein | Rivista di Filosofia, Vol. 9 No. 1 (2021): Eudaimonia socratica e cura dell’altro | Socratic Eudaimonia and Care for Others
Cost/benefit evaluations in low-middle/upper-middle income countries: biases about “out of pocket money”
Creators: name: Mustacchi, Giorgio
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Cost/benefit evaluations in low-middle/upper-middle income countries: biases about “out of pocket money”
OS ALIMENTOS COMPENSATÓRIOS E SUA NATUREZA JURÍDICA
Creators: name: Elaine Zelaquett de Souza Correia
name: Sander Fítney Brandão de Menezes Correia
name: Alexei José Esteves
name: Diogo Severino Ramos da Silva
Publisher: name: Zenodo
Year: 2022

description: RESUMO

O presente artigo trata dos alimentos compensatórios devidos aos ex-cônjuges e ex-companheiros. Analisa sob o enfoque da dissolução da sociedade conjugal e dos conviventes, como forma de indenização, tendo em vista o abalo no padrão de vida. Discorre sobre as diferenças de alimentos e alimentos compensatórios. Aborda a admissibilidade, a natureza jurídica e fundamento dos alimentos compensatórios, tendo como supedâneo os princípios constitucionais da igualdade, solidariedade, dignidade, responsabilidade, bem como do enriquecimento sem causa. Destaca o reconhecimento pelos tribunais brasileiros do novel instituto. Elucida a situação da ex-primeira dama Rosane Collor, com o deferimento pelo Superior Tribunal de Justiça dos alimentos compensatórios. Finaliza que os alimentos compensatórios representam uma forma de reparação financeira, a fim de conter desigualdades, tendo em vista o abalo no padrão de vida sofrido por um dos ex-cônjuges e ex-companheiros.

Palavras-chave: Direito de Família. Responsabilidade Civil. Dissolução sociedade afetiva. Alimentos compensatórios.
Hospitalization risk among adults with bipolar I disorder treated with lurasidone versus other oral atypical antipsychotics: a retrospective analysis of Medicaid claims data
Creators: name: Niu, Xiaoli
name: Veeranki, Phani
name: Dennen, Syvart
name: Dembek, Carole
name: Laubmeier, Kimberly
name: Liu, Yanmei
name: Williams, G. Rhys
name: Loebel, Antony
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Mental Health

description: To compare the risk of hospitalization for adult Medicaid beneficiaries with bipolar I disorder treated with lurasidone vs. other oral atypical antipsychotics (AAPs) as monotherapy. A retrospective cohort study of the IBM MarketScan Multi-State Medicaid Claims database identified adults with bipolar I disorder who initiated an AAP (index date) between 1 January 2014 and 30 June 2019. Patients were continuously enrolled 12 months pre- and 24 months post-index date. Each month during the post-index period was categorized as monotherapy with lurasidone, aripiprazole, olanzapine, quetiapine or risperidone, no/minimal treatment, or other. Marginal structural models were performed to estimate hospitalization risk and length of stay (LOS) (all-cause and bipolar I disorder-related) compared to lurasidone. The analysis included 8262 adults. Compared to lurasidone, the adjusted odds ratios (aORs) of all-cause hospitalization were significantly higher for olanzapine (aOR = 1.60, 95% CI = 1.09–2.10) and quetiapine (aOR = 1.54, 95% CI = 1.18–1.89). The risk was significantly higher for bipolar I disorder-related hospitalization for quetiapine (aOR = 1.57, 95% CI = 1.10–2.04) and risperidone (aOR = 1.80, 95% CI = 1.04–2.56) compared to lurasidone. The bipolar I disorder-related LOS per 100 patient-months was more than twice as long for quetiapine (8.42 days) compared to lurasidone (3.97 days, p < .01). Lurasidone-treated adult Medicaid patients with bipolar I disorder had significantly lower risk of all-cause hospitalization than those treated with olanzapine and quetiapine and lower risk of bipolar I disorder-related hospitalization than quetiapine and risperidone. Bipolar I disorder-related hospital LOS was significantly shorter for patients treated with lurasidone compared to quetiapine.
Dialettica, virtù e felicità nei socratici
Creators: name: Chame, Santiago
Publisher: name: Thaumàzein | Rivista di Filosofia
Year: 2022

description: Dialectics, virtue and happiness among the Socratics My purpose in this paper is to evaluate the diverse points of contact and divergence between Xenophon, Plato and Antisthenes on the question of dialectics. I contend that, although each of these philosophers presents a different approach to dialectics, all three share a common characteristic that makes their positions structurally analogous. I will begin by analyzing an important passage of Xenophon, in which this common characteristic is perhaps most visible, in order to later establish a comparison with Plato and Antisthenes. In addition, this analysis will bring forth the fundamental relationship which exists between dialectics, virtue, and happiness.
description: Thaumàzein | Rivista di Filosofia, Vol. 9 No. 1 (2021): Eudaimonia socratica e cura dell’altro | Socratic Eudaimonia and Care for Others