cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Clustering memes in social media streams
Creators: name: JafariAsbagh, Mohsen
name: Ferrara, Emilio
name: Varol, Onur
name: Menczer, Filippo
name: Flammini, Alessandro
Publisher: name: arXiv
Year: 2014
Subjects: subject: Social and Information Networks (cs.SI)
subject: Computers and Society (cs.CY)
subject: Machine Learning (cs.LG)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: The problem of clustering content in social media has pervasive applications, including the identification of discussion topics, event detection, and content recommendation. Here we describe a streaming framework for online detection and clustering of memes in social media, specifically Twitter. A pre-clustering procedure, namely protomeme detection, first isolates atomic tokens of information carried by the tweets. Protomemes are thereafter aggregated, based on multiple similarity measures, to obtain memes as cohesive groups of tweets reflecting actual concepts or topics of discussion. The clustering algorithm takes into account various dimensions of the data and metadata, including natural language, the social network, and the patterns of information diffusion. As a result, our system can build clusters of semantically, structurally, and topically related tweets. The clustering process is based on a variant of Online K-means that incorporates a memory mechanism, used to "forget" old memes and replace them over time with the new ones. The evaluation of our framework is carried out by using a dataset of Twitter trending topics. Over a one-week period, we systematically determined whether our algorithm was able to recover the trending hashtags. We show that the proposed method outperforms baseline algorithms that only use content features, as well as a state-of-the-art event detection method that assumes full knowledge of the underlying follower network. We finally show that our online learning framework is flexible, due to its independence of the adopted clustering algorithm, and best suited to work in a streaming scenario.
description: 25 pages, 8 figures, accepted on Social Network Analysis and Mining (SNAM). The final publication is available at Springer via http://dx.doi.org/10.1007/s13278-014-0237-x
Polymer and Crosslinker Content Influences Performance of Encapsulated Live Biotherapeutic Products
Creators: name: Huang, Y.
name: Anselmo, A.C.
name: Qiu, K.
Publisher: name: Springer
Year: 2021

description: Introduction: Live biotherapeutic products (LBPs), or therapeutic microbes, are an emerging therapeutic modality for prevention and treatment of gastrointestinal diseases. Since LBPs are living, they are uniquely sensitive to external stresses (e.g., oxygen, acid) encountered during manufacturing, storage, and delivery. Here, we systematically evaluate how polymer and crosslinker concentration affects the performance of an encapsulated LBP toward developing a comprehensive framework for the characterization and optimization of LBP delivery systems. Methods: We encapsulate a model LBP, Lactobacillus casei ATCC 393, in calcium chloride (CaCl2)-crosslinked alginate beads, and evaluate how alginate and CaCl2 concentrations influence LBP formulation performance, including: (i) encapsulation efficiency, (ii) shrinkage upon drying, (iii) survival upon lyophilization, (iv) acid resistance, (v) release, and (vi) metabolite secretion. Approaches from microbiology (e.g., colony forming unit enumeration), materials science (e.g., scanning electron microscopy), and pharmaceutical sciences (e.g., release assays) are employed. Results: LBP-encapsulating alginate beads were systematically evaluated as a function of alginate and CaCl2 concentrations. Specifically: (i) encapsulation efficiency of all formulations was >50%, (ii) all alginate beads shrunk (after lyophilization) and recovered (after rehydration) similarly, (iii) at 10% alginate concentration, lower CaCl2 concentration decreased survival upon lyophilization, (iv) 10% alginate improved acid resistance, (v) sustained release was enabled by increasing alginate and CaCl2 concentrations, and (vi) encapsulation did not impair secretion of l-lactate as compared to free LBP. Conclusions: This research demonstrates that polymer content and crosslinking extent modulate the performance of polymer-based LBP delivery systems, motivating research into the optimization of material properties for LBP delivery systems.
COSIMA-Rosetta calibration for in-situ characterization of 67P/Churyumov-Gerasimenko cometary inorganic compounds
Creators: name: Krüger, Harald
name: Stephan, Thomas
name: Engrand, Cécile
name: Briois, Christelle
name: Siljeström, Sandra
name: Merouane, Sihane
name: Baklouti, Donia
name: Fischer, Henning
name: Fray, Nicolas
name: Hornung, Klaus
name: Lehto, Harry
name: Orthous-Daunay, François-Régis
name: Rynö, Jouni
name: Schulz, Rita
name: Silen, Johan
name: Thirkell, Laurent
name: Trieloff, Mario
name: Hilchenbach, Martin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: COSIMA (COmetary Secondary Ion Mass Analyser) is a time-of-flight secondary ion mass spectrometer (TOF-SIMS) on board the Rosetta space mission. COSIMA has been designed to measure the composition of cometary dust grains. It has a mass resolution m/Δm of 1400 at mass 100 u, thus enabling the discrimination of inorganic mass peaks from organic ones in the mass spectra. We have evaluated the identification capabilities of the reference model of COSIMA for inorganic compounds using a suite of terrestrial minerals that are relevant for cometary science. Ground calibration demonstrated that the performances of the flight model were similar to that of the reference model. The list of minerals used in this study was chosen based on the mineralogy of meteorites, interplanetary dust particles and Stardust samples. It contains anhydrous and hydrous ferromagnesian silicates, refractory silicates and oxides (present in meteoritic Ca-Al-rich inclusions), carbonates, and Fe-Ni sulfides. From the analyses of these minerals, we have calculated relative sensitivity factors for a suite of major and minor elements in order to provide a basis for element quantification for the possible identification of major mineral classes present in the cometary grains.
description: 20 pages, 3 figures, 5 tables
(500385) Henry Hall
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Vacuum metastability with black holes
Creators: name: Burda, Philipp
name: Gregory, Ruth
name: Moss, Ian
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We consider the possibility that small black holes can act as nucleation seeds for the decay of a metastable vacuum, focussing particularly on the Higgs potential. Using a thin-wall bubble approximation for the nucleation process, which is possible when generic quantum gravity corrections are added to the Higgs potential, we show that primordial black holes can stimulate vacuum decay. We demonstrate that for suitable parameter ranges, the vacuum decay process dominates over the Hawking evaporation process. Finally, we comment on the application of these results to vacuum decay seeded by black holes produced in particle collisions.
description: 34 pages, 9 figures, published version
Phonon and Raman scattering of two-dimensional transition metal dichalcogenides from monolayer, multilayer to bulk material
Creators: name: Zhang, Xin
name: Qiao, Xiao-Fen
name: Shi, Wei
name: Wu, Jiang-Bin
name: Jiang, De-Sheng
name: Tan, Ping-Heng
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Two-dimensional (2D) transition metal dichalcogenide (TMD) nanosheets exhibit remarkable electronic and optical properties. The 2D features, sizable bandgaps, and recent advances in the synthesis, characterization, and device fabrication of the representative MoS$_2$, WS$_2$, WSe$_2$, and MoSe$_2$ TMDs make TMDs very attractive in nanoelectronics and optoelectronics. Similar to graphite and graphene, the atoms within each layer in 2D TMDs are joined together by covalent bonds, while van der Waals interactions keep the layers together. This makes the physical and chemical properties of 2D TMDs layer dependent. In this review, we discuss the basic lattice vibrations of monolayer, multilayer, and bulk TMDs, including high-frequency optical phonons, interlayer shear and layer breathing phonons, the Raman selection rule, layer-number evolution of phonons, multiple phonon replica, and phonons at the edge of the Brillouin zone. The extensive capabilities of Raman spectroscopy in investigating the properties of TMDs are discussed, such as interlayer coupling, spin--orbit splitting, and external perturbations. The interlayer vibrational modes are used in rapid and substrate-free characterization of the layer number of multilayer TMDs and in probing interface coupling in TMD heterostructures. The success of Raman spectroscopy in investigating TMD nanosheets paves the way for experiments on other 2D crystals and related van der Waals heterostructures.
description: 30 pages, 23 figures
Stochastic duality of ASEP with two particle types via symmetry of quantum groups of rank two
Creators: name: Kuan, Jeffrey
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: Mathematical Physics (math-ph)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We study two generalizations of the asymmetric simple exclusion process with two types of particles. Particles of type 1 can jump over particles of type 2, while particles of type 2 can only influence the jump rates of particles of type 1. We prove that the processes are self-dual and explicitly write the duality function. As an application, an expression for the r-th moment of the exponentiated current is written in terms of r-particle evolution. The construction and proofs of duality are accomplished using symmetry of the quantum groups $U_q(\mathfrak{gl}_3)$ and $U_q(\mathfrak{sp}_4)$, with each node in the Dynkin diagram corresponding to a particle type, and the number of edges corresponding to the jump rates.
Canine Economies of the Ancient Near East and Eastern Mediterranean
Creators: name: Arbuckle, B.
name: Meier, J.
name: Price, M.
Publisher: name: Taylor and Francis Ltd.
Year: 2021

description: Archaeological assemblages, texts, and iconography indicate a multifaceted, yet often ignored, canine economy in the ancient eastern Mediterranean and Near East. This economy included not only dogs’ celebrated roles as hunting aids, guards, village scavengers, and companions, but also the regular processing, use, and consumption of dogs for foods, hides, and medicinal/ritual purposes. Drawing on ethnohistorical information and zooarchaeological data from three Chalcolithic/Bronze Age sites—Tell Surezha (Iraq), Mycenae (Greece), and Acemhöyük (Turkey)—we emphasize evidence for the processing of dog carcasses, which reflect a range of post-mortem treatments of dog bodies. We suggest the widespread use of primary products from dogs, features of an ancient canine economy that are rarely reported on in depth and often explained away as aberrations by modern scholars of the region. We speculate that this neglect stems in part from analysts’ taboos on cynophagy (unconsciously) influencing archaeological reconstructions of dog use in the past.
(500387) Harry Grey
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Emergency Departments as Settings for Vaccination
Creators: name: Lucke, Austin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: Study Objectives: The Emergency Department has, historically, been minimally involved with vaccination efforts. With the exception of tetanus and rabies vaccines, vaccinations are typically not distributed in this setting. However, as the country and the world continues to fight the COVID-19 pandemic, determining new methods to deliver vaccines to people is now more important than ever. Moreover, finding ways to reach populations that are less likely to receive vaccines is equally as important. The objective of this study was to implement a screening and delivery protocol for seasonal influenza vaccine in an Emergency Department setting to demonstrate that Emergency Department vaccination protocols are viable public health tools.
Methods: A screening protocol was developed based on CDC/ACIP guidelines for Influenza vaccination. This screening protocol was implemented at two academic emergency departments starting 10/01/2020 and ending 01/31/2020. I collected demographic information from the electronic medical records of all patients who were screened and used that information to characterize who was accepting or refusing the vaccination.
Results: During the trial period, 11,355 patients were screened out of 25,485 total patients who presented to the participating Emergency Departments. Out of that 11,355, 5,056 (45%) stated they had not received the influenza vaccine. Among those 5,056 people eligible for the vaccine, 1,156 (22.9%) of patients had an order placed for a vaccine and ultimately 441 (8.7%) received the vaccination. Among the participants, the patients identifying as African American or Hispanic were less likely already to have received the influenza vaccine than were non-Hispanic white and Asian identifying patients. Patients identifying as African American were the least likely to accept the vaccination. Conversely, patients identifying as Hispanic were more likely to accept vaccination. Patients identifying as Asian were the most likely to have already received the vaccine and to accept the vaccine when offered.
Conclusions: This study demonstrates that seasonal influenza vaccination in the Emergency Department is feasible although we found substantial room for improvement in vaccinating those eligible and acceptance varied by race/ethnicity. The patient population using the emergency department is more likely to comprise medically underserved populations and this is a good opportunity to increase vaccination rates in those populations. These results should motivate the implementation of vaccination programs in other Emergency Departments for both the influenza virus and the COVID-19 virus.
(500388) Wm. C. Harris
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Expanding the View of IKK: New Substrates and New Biology
Creators: name: Hagan, R.S.
name: Antonia, R.J.
name: Baldwin, A.S.
Publisher: name: Elsevier Ltd
Year: 2021

description: The inhibitor of kappa B kinase (IKK) family consists of IKKα, IKKβ, and the IKK-related kinases TBK1 and IKKε. These kinases are considered master regulators of inflammation and innate immunity via their control of the transcription factors NF-κB, IRF3, and IRF7. Novel phosphorylated substrates have been attributed to these kinases, a subset of which is not directly related to either inflammation or innate immunity. These findings have greatly expanded the perspectives on the biological activities of these kinases. In this review we highlight some of the novel substrates for this kinase family and discuss the biological implications of these phosphorylation events.
(500391) Charlotte Allen
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Future wheat security: practical approaches to stabilize global wheat
Creators: name: Bentley, Alison
name: Donovan, Jason
Publisher: name: Zenodo
Year: 2022
Subjects: Ukraine, Russia, conflict, wheat trade, wheat exports, wheat imports, food security, human nutrition

description: Wheat is an essential component of global trade and food security. The current crisis in Ukraine has led to wheat price increases which are likely to have medium- to long-term impacts on global food security. In this presentation (delivered as part of the #IFPRIPolicySeminar on "Global Commodity Prices and Food Security: navigating new challenges and learning from the past") we outline the status of wheat exports and imports as well as highlighting lessons from the past to inform our future approaches. We highlight that the issue-attention cycles are re-starting (focused on short-term mitigation) and argue that new ways of working are required that take a long-term view to "short-term" problems, including donor engagement, accountability in partnerships and stronger cross-disciplinarity, in particular bring together bio-physical and social science. Specific to global wheat stability we present applied avenues for co-ordinated action: increasing and expanding production, de-risking biophysical supply risks, supporting paths to self-reliance and balancing focus between food and systems diversity.
On The Organization Of Human T Cell Receptor Loci
Creators: name: Toor, Amir A.
name: Toor, Abdullah A.
name: Manjili, Masoud H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Genomics (q-bio.GN)
subject: FOS: Biological sciences

description: The human T cell repertoire is generated by the rearrangement of variable (V), diversity (D) and joining (J) segments on the T cell receptor (TCR) loci. To determine whether the structural ordering of these gene segments on the TCR loci contributes to the observed clonal frequencies, the TCR loci were examined for self-similarity and periodicity in terms of gene segment organization. Logarithmic transformation of numeric sequence order demonstrated that the V and J gene segments for both T cell receptor alpha (TRA) and beta (TRB) loci were arranged in a self-similar manner when the spacing between adjacent segments was considered as a function of the size of the neighboring gene segment. The ratio of genomic distance between either the J (in TRA) or D (in TRB) segments and successive V segments on these loci declined logarithmically. Accounting for the gene segments occurring on helical DNA molecules, in a logarithmic distribution, sine and cosine functions of the log transformed angular coordinates of the start and stop nucleotides of successive TCR gene segments showed an ordered progression across the locus, supporting a log-periodic organization. T cell clonal frequencies, based on V and J segment usage, from three normal stem cell donors plotted against the respective segment locations on TRB locus demonstrated a periodic variation. We hypothesize that this quasi-periodic variation in T cell clonal repertoire may be influenced by the location of the gene segments on the logarithmically scaled TCR loci. Interactions between the two strands of DNA in the double helix may influence the probability of gene segment usage by means of either constructive or destructive interference resulting from the superposition of the two helices, impacting probability of DNA recombination.
description: 27 Pages, 6 Figures, 2 Supplementary Figures
Deliverable 3.4 Transferability Report
Creators: name: ICLEI Europe
name: Metropolitan Research Institute, Hungary
Publisher: name: Zenodo
Year: 2022
Subjects: case study
Reflexive Policy Making
capability approach
social innovation
policy recommendations

description: The implementation of Reflexive Policy Making (RPM), that is the social innovation tested in the framework of the UPLIFT project, is grounded in intensive research work. Qualitative research informed the development of the project by investigating the drivers of young people's inequalities and mapping existing counteracting measures. More precisely, the research carried out in eight European cities and published in the Case Study Reports applied the Capability Approach (CA) to capture the complex socio-economic environment around young people and recommend possible topics for RPM. The eight analysed cities are Amadora (Portugal), Amsterdam (The Netherlands), Barakaldo (Spain), Corby, (the UK), Chemnitz, (Germany), Pecs (Hungary), Sfantu Gheorghe (Romania) and Tallinn (Estonia).
Coronae and Winds from Irradiated Disks in X-ray binaries
Creators: name: Higginbottom, Nick
name: Proga, Daniel
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: X-ray and UV line emission in X-ray binaries can be accounted for by a hot corona. Such a corona forms through irradiation of the outer disk by radiation produced in the inner accretion flow. The same irradiation can produce a strong outflow from the disk at sufficiently large radii. Outflowing gas has been recently detected in several X-ray binaries via blue-shifted absorption lines. However, the causal connection between winds produced by irradiation and the blue-shifted absorption lines is problematic, particularly in the case of GRO J1655-40. Observations of this source imply wind densities about two orders of magnitude higher than theoretically predicted. This discrepancy does not mean that these `thermal disk-winds' cannot explain blue-shifted absorption in other systems, nor that they are unimportant as a sink of matter. Motivated by the inevitability of thermal disk-winds and wealth of data taken with current observatories such as Chandra, XMM-Newton and Suzaku, as well as the future AstroH mission, we decided to investigate the requirements to produce very dense winds. Using physical arguments, hydrodynamical simulations and absorption line calculations, we found that modification of the heating and cooling rates by a factor of a few results in an increase of the wind density of up to an order of magnitude and the wind velocity by a factor of about two. Therefore, the mass loss rate from the disk can be one, if not even two orders of magnitude higher than the accretion rate onto the central object. Such a high mass loss rate is expected to destabilize the disk and perhaps provides a mechanism for state change.
description: 14 pages, 3 figures, accepted for publication in ApJ
(500383) Mary A King
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(500380) Henry Russell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
TBK1 is a synthetic lethal target in cancer with VHL loss
Creators: name: Chen, X.
name: Herring, L.E.
name: James, L.I.
name: Tan, X.
name: Xie, L.
name: Cabrera, J.C.
name: Hong, K.
name: Potjewyd, F.
name: Gong, K.
name: Wilkerson, E.M.
name: Liu, X.
name: Baldwin, A.S.
name: Hu, L.
name: Xie, H.
name: Liao, C.
name: Zhang, Q.
Publisher: name: American Association for Cancer Research Inc.
Year: 2020

description: TANK binding kinase 1 (TBK1) is an important kinase involved in the innate immune response. Here we discover that TBK1 is hyperactivated by von Hippel-Lindau (VHL) loss or hypoxia in cancer cells. Tumors from patients with kidney cancer with VHL loss display elevated TBK1 phosphorylation. Loss of TBK1 via genetic ablation, pharmacologic inhibition, or a new cereblonbased proteolysis targeting chimera specifically inhibits VHL-deficient kidney cancer cell growth, while leaving VHL wild-type cells intact. TBK1 depletion also significantly blunts kidney tumorigenesis in an orthotopic xenograft model in vivo. Mechanistically, TBK1 hydroxylation on Proline 48 triggers VHL as well as the phosphatase PPM1B binding that leads to decreased TBK1 phosphorylation. We identify that TBK1 phosphorylates p62/SQSTM1 on Ser366, which is essential for p62 stability and kidney cancer cell proliferation. Our results establish that TBK1, distinct from its role in innate immune signaling, is a synthetic lethal target in cancer with VHL loss. SIGNIFICANCE: The mechanisms that lead to TBK1 activation in cancer and whether this activation is connected to its role in innate immunity remain unclear. Here, we discover that TBK1, distinct from its role in innate immunity, is activated by VHL loss or hypoxia in cancer.
Uncovering causes of stagnating product sales of a healthy snack: A system dynamics group model building project in a food processing company
Creators: name: Horvat, Andrijana
name: Bartelet, Henry Antoine
name: Andersen, David F.
name: Behdani, Behzad
name: Luning, Pieternel A.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Product life cycle (PLC) analysis studies patterns of sales over time and the reasons behind those patterns. Such analysis can be challenging because of the interconnected effect of technical product characteristics, marketing mix elements, and the environment (e.g. competition, consumers). Moreover, employees from different functions have different backgrounds and perceptions about the origins of patterns, which constrains mutual understanding and hampers decision-making. The group model building (GMB) approach can be an effective method to support teams in solving complex dynamic problems, such as a PLC analysis of product sales. This study uses a GMB approach and presents a system dynamics model, which supported cross-functional collaboration in analysing causes of stagnating product sales in the PLC of a healthy snack product in a food processing company. Through multiple GMB sessions with the company team, a system dynamics model was developed, and several strategies were analysed. The model has proven useful in explaining the reasons behind the sales stagnation and in studying possible interventions. Moreover, GMB was successful in increasing participants’ insight into the causes of the problem, improving communication, and creating a shared vision about the problem.
Evidence of $Wγγ$ production in $pp$ collisions at $\sqrt{s}=8$ TeV and limits on anomalous quartic gauge couplings with the ATLAS detector
Creators: name: ATLAS Collaboration
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: This Letter reports evidence of triple gauge boson production $pp\to W(\ellν)γγ+ X$, which is accessible for the first time with the 8 TeV LHC data set. The fiducial cross section for this process is measured in a data sample corresponding to an integrated luminosity of 20.3 fb$^{-1}$, collected by the ATLAS detector in 2012. Events are selected using the $W$ boson decay to $eν$ or $μν$ as well as requiring two isolated photons. The measured cross section is used to set limits on anomalous quartic gauge couplings in the high diphoton mass region.
description: 8 pages plus author list + cover pages (26 pages total), 1 figure, 4 tables, submitted to PRL, All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2013-05
Genome-wide DNA methylation analysis of KRAS mutant cell lines
Creators: name: Tew, B.Y.
name: Gooden, G.C.
name: Buckley, D.N.
name: Salhia, B.
name: Hayes, T.K.
name: Der, C.J.
name: Baldwin, A.S.
name: Durand, J.K.
name: Tran, N.L.
name: Bryant, K.L.
name: Peng, S.
Publisher: name: Nature Research
Year: 2020

description: Oncogenic RAS mutations are associated with DNA methylation changes that alter gene expression to drive cancer. Recent studies suggest that DNA methylation changes may be stochastic in nature, while other groups propose distinct signaling pathways responsible for aberrant methylation. Better understanding of DNA methylation events associated with oncogenic KRAS expression could enhance therapeutic approaches. Here we analyzed the basal CpG methylation of 11 KRAS-mutant and dependent pancreatic cancer cell lines and observed strikingly similar methylation patterns. KRAS knockdown resulted in unique methylation changes with limited overlap between each cell line. In KRAS-mutant Pa16C pancreatic cancer cells, while KRAS knockdown resulted in over 8,000 differentially methylated (DM) CpGs, treatment with the ERK1/2-selective inhibitor SCH772984 showed less than 40 DM CpGs, suggesting that ERK is not a broadly active driver of KRAS-associated DNA methylation. KRAS G12V overexpression in an isogenic lung model reveals >50,600 DM CpGs compared to non-transformed controls. In lung and pancreatic cells, gene ontology analyses of DM promoters show an enrichment for genes involved in differentiation and development. Taken all together, KRAS-mediated DNA methylation are stochastic and independent of canonical downstream effector signaling. These epigenetically altered genes associated with KRAS expression could represent potential therapeutic targets in KRAS-driven cancer.
title: Übersetzung in Türkisch: Angststörungen
Creators: name: Ärztliches Zentrum Für Qualität In Der Medizin (ÄZQ)
Publisher: name: Bundesärztekammer (BÄK); Kassenärztliche Bundesvereinigung (KBV); Ärztliches Zentrum für Qualität in der Medizin (ÄZQ)
Year: 2016
Subjects: subject: 610 Medical sciences; Medicine

description: Kurzinformation für Patienten
(500381) Maria Smithers
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
On the proper kinetic quadrupole CMB removal and the quadrupole anomalies
Creators: name: Notari, Alessio
name: Quartin, Miguel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: It has been pointed out recently that the quadrupole-octopole alignment in the CMB data is significantly affected by the so-called kinetic Doppler quadrupole (DQ), which is the temperature quadrupole induced by our proper motion. Assuming our velocity is the dominant contribution to the CMB dipole we have v/c = beta = (1.231 +/- 0.003) * 10^{-3}, which leads to a non-negligible DQ of order beta^2. Here we stress that one should properly take into account that CMB data are usually not presented in true thermodynamic temperature, which induces a frequency dependent boost correction. The DQ must therefore be multiplied by a frequency-averaged factor, which we explicitly compute for several CMB maps finding that it varies between 1.67 and 2.47. This is often neglected in the literature and turns out to cause a small but non-negligible difference in the significance levels of some quadrupole-related statistics. For instance the alignment significance in the SMICA 2013 map goes from 2.3sigma to 3.3sigma, with the frequency dependent DQ, instead of 2.9sigma ignoring the frequency dependence in the DQ. Moreover as a result of a proper DQ removal, the agreement across different map-making techniques is improved.
description: v2: improvements to the text; 2 figures and several references added; results unchanged. [14 pages, 3 tables, 2 figures]
Combining Technical and Financial Impacts for Countermeasure Selection
Creators: name: Gonzalez-Granadillo, Gustavo
name: Ponchel, Christophe
name: Blanc, Gregory
name: Debar, Hervé
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cryptography and Security (cs.CR)
subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences

description: Research in information security has generally focused on providing a comprehensive interpretation of threats, vulnerabilities, and attacks, in particular to evaluate their danger and prioritize responses accordingly. Most of the current approaches propose advanced techniques to detect intrusions and complex attacks but few of these approaches propose well defined methodologies to react against a given attack. In this paper, we propose a novel and systematic method to select security countermeasures from a pool of candidates, by ranking them based on the technical and financial impact associated to each alternative. The method includes industrial evaluation and simulations of the impact associated to a given security measure which allows to compute the return on response investment for different candidates. A simple case study is proposed at the end of the paper to show the applicability of the model.
description: In Proceedings AIDP 2014, arXiv:1410.3226
title: Prefazione
Creators: name: Panizza  ,  Mario
Publisher: name: Roma TrE-Press
Year: 2014

description: L’attenzione al territorio è vitale e può ricevere da un paesaggio antropizzato, quasi intatto come Villa Maruffi, un impulso nuovo per pensare a forme di tutela che non congelino il passato, ma che ne sappiano cogliere il punto di equilibrio tra conservazione e innovazione. Curare l’ambiente oggi significa prevedere un’azione totale che va dall’attenzione al valore culturale dei luoghi storici alla responsabilità del loro mantenimento. Nel pensiero ecologico troviamo gli strumenti per tutelare sia lo spazio naturale sia quello costruito. Impegnarsi in un progetto sostenibile significa integrare la conoscenza e la consapevolezza del valore dell’ambiente all’uso razionale delle risorse.
description: Terre Antichità Memorie. La raccolta numismatica Maruffi
Betacellulin drives therapy resistance in glioblastoma
Creators: name: Shokat, K.M.
name: Baldwin, A.
name: Wong, R.A.
name: Weiss, W.A.
name: Luo, X.
name: Haderk, F.
name: Bivona, T.G.
name: Fan, Q.
name: Mayekar, M.K.
name: An, Z.
name: Lu, E.D.
Publisher: name: Oxford University Press
Year: 2020

description: Background: The transcription factor signal transducer and activator of transcription 3 (STAT3) drives progression in glioblastoma (GBM), suggesting STAT3 as a therapeutic target. Surprisingly however, GBM cells generally show primary resistance to STAT3 blockade. Methods: Human glioblastoma cell lines LN229, U87, SF767, and U373, and patient-derived xenografts (PDXs) GBM8 and GBM43 were used to evaluate epidermal growth factor receptor (EGFR) activation during STAT3 inhibition. Protein and gene expression experiments, protein stability assays, cytokine arrays, phospho-tyrosine arrays and EGFR-ligand protein arrays were performed on STAT3 inhibitor-treated cells. To evaluate antitumor activity, we administered a betacellulin (BTC)-neutralizing antibody alone and in combination with STAT3 inhibition. BTC is an EGFR ligand. We therefore treated mice with orthotopic xenografts using the third-generation EGFR inhibitor osimertinib, with or without STAT3 knockdown. Results: We demonstrate that both small-molecule inhibitors and knockdown of STAT3 led to expression and secretion of the EGFR ligand BTC, resulting in activation of EGFR and subsequent downstream phosphorylation of nuclear factor-kappaB (NF-κB). Neutralizing antibody against BTC abrogated activation of both EGFR and NF-κB in response to inhibition of STAT3; with combinatorial blockade of STAT3 and BTC inducing apoptosis in GBM cells. Blocking EGFR and STAT3 together inhibited tumor growth, improving survival in mice bearing orthotopic GBM PDXs in vivo. Conclusion: These data reveal a feedback loop among STAT3, EGFR, and NF-κB that mediates primary resistance to STAT3 blockade and suggest strategies for therapeutic intervention.
The Abundance of X-Shaped Radio Sources: Implications for the Gravitational Wave Background
Creators: name: Roberts, David H.
name: Saripalli, Lakshmi
name: Subrahmanyan, Ravi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Coalescence of super massive black holes (SMBH's) in galaxy mergers is potentially the dominant contributor to the low frequency gravitational wave background (GWB). IIt was proposed by Merritt and Ekers (2002) that X-shaped radio galaxies are signposts of such coalescences, and that their abundance might be used to predict the magnitude of the gravitational wave background. In Roberts et al. (2015) we present radio images of all 52 X-shaped radio source candidates out of the sample of 100 selected by Cheung (2007) for which archival VLA data were available. These images indicate that at most 21% of the candidates might be genuine X-shaped radio sources that were formed by a restarting of beams in a new direction following a major merger. This suggests that fewer than 1.3% of extended radio sources appear to be candidates for genuine axis reorientations ("spin flips"), much smaller than the 7% suggested by Leahy and Parma (1992). Thus the associated gravitational wave background may be substantially smaller than previous estimates. These results can be used to normalize detailed calculations of the SMBH coalescence rate and the GWB.
(500386) Frederick Hill
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss
Creators: name: Ptacek, T.S.
name: Tan, X.
name: Kirschner, M.W.
name: Simon, J.M.
name: Herring, L.
name: Kim, W.Y.
name: Xie, H.
name: Liu, X.
name: Hu, L.
name: Li, M.
name: Baldwin, A.S.
name: Wang, J.
name: Gong, K.
name: Wu, T.
name: Fan, C.
name: Zhang, Q.
name: Zurlo, G.
Publisher: name: Cell Press
Year: 2020

description: von Hippel-Lindau (VHL) is a critical tumor suppressor in clear cell renal cell carcinomas (ccRCCs). It is important to identify additional therapeutic targets in ccRCC downstream of VHL loss besides hypoxia-inducible factor 2α (HIF2α). By performing a genome-wide screen, we identified Scm-like with four malignant brain tumor domains 1 (SFMBT1) as a candidate pVHL target. SFMBT1 was considered to be a transcriptional repressor but its role in cancer remains unclear. ccRCC patients with VHL loss-of-function mutations displayed elevated SFMBT1 protein levels. SFMBT1 hydroxylation on Proline residue 651 by EglN1 mediated its ubiquitination and degradation governed by pVHL. Depletion of SFMBT1 abolished ccRCC cell proliferation in vitro and inhibited orthotopic tumor growth in vivo. Integrated analyses of ChIP-seq, RNA-seq, and patient prognosis identified sphingosine kinase 1 (SPHK1) as a key SFMBT1 target gene contributing to its oncogenic phenotype. Therefore, the pVHL-SFMBT1-SPHK1 axis serves as a potential therapeutic avenue for ccRCC. © 2020 Elsevier Inc.The pVHL-SFMBT1-SPHK1 axis serves as a potential therapeutic avenue for ccRCC.
title: Prefazione
Creators: name: Calandra  ,  Elena
Publisher: name: Roma TrE-Press
Year: 2014

description: Il significato del volume è racchiuso già nel trinomio del titolo, che rispecchia la sequenza logica alla base della raccolta Maruffi: i terreni punteggiati di evidenze antiche costituiscono per densità di ritrovamenti una piattaforma di riflessione imprescindibile, che alimenta la memoria perpetuata dai materiali. La specifica ulteriore, riferita alla raccolta numismatica, riguarda il contenuto di buona parte del volume, dedicato sia all’inquadramento generale, topografico e storico, sia all’edizione critica del corpus monetale.
description: Terre Antichità Memorie. La raccolta numismatica Maruffi
(500379) Maria Ellaby
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Interprétation de la chanson "La Saladello" (la Saladelle) par Alphonse Arnaud, le capitaine des gardians, et ses hommes
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2024

Abstract
Non-Abelian Vortices with a Twist
Creators: name: Forgacs, Peter
name: Lukacs, Arpad
name: Schaposnik, Fidel A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Non-Abelian flux-tube (string) solutions carrying global currents are found in the bosonic sector of 4-dimensional N=2 super-symmetric gauge theories. The specific model considered here posseses U(2)local x SU(2)global symmetry, with two scalar doublets in the fundamental representation of SU(2). We construct string solutions that are stationary and translationally symmetric along the x3 direction, and they are characterized by a matrix phase between the two doublets, referred to as "twist". Consequently, twisted strings have nonzero (global) charge, momentum, and in some cases even angular momentum per unit length. The planar cross section of a twisted string corresponds to a rotationally symmetric, charged non-Abelian vortex, satisfying 1st order Bogomolny-type equations and 2nd order Gauss-constraints. Interestingly, depending on the nature of the matrix phase, some of these solutions even break rotational symmetry in R3. Although twisted vortices have higher energy than the untwisted ones, they are expected to be linearly stable since one can maintain their charge (or twist) fixed with respect to small perturbations.
description: 18 pages, 5 figures