cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Русский язык и культура речи
Creators: name: ELS IPR BOOKS
Publisher: name: Новосибирский государственный университет экономики и управления «НИНХ»
Year: 2020

description: Настоящий практикум содержит упражнения, тестовые, творческие и контрольные задания по основным темам дисциплины «Русский язык и культура речи», а также краткие сведения теоретического характера, необходимые для практического освоения курса. Практикум предназначен для проведения факультативных занятий для студентов всех направлений экономических вузов.
Assessment of children with narrative story stem techniques: a systematic review of existing instruments
Creators: name: Løkkegaard, Sille
name: Elmose, Mette
name: Elklit, Ask
name: Lindekilde, Nanna
name: Daniunaite, Ieva
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: Life Sciences
subject: Social and Behavioral Sciences
subject: assessment
subject: doll-play
subject: narrative representation
subject: Narratives
subject: Preschool and young school children
subject: Reliability
subject: Story stems
subject: Validity

description: A systematic review of story stem instruments for children aged 3-12 years. A narrative, mixed-methods synthesis will be applied.
title: Pulmonary nontuberculous mycobacterial infection (NTM): radiographic findings
Creators: name: Cano Rodriguez, Carlota
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Infection
subject: Cavitation
subject: Education
subject: Diagnostic procedure
subject: CT
subject: Thorax

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The increase in the number of infections with nontuberculous mycobacteria (NTM) in immunocompetent patients has led to greater interest in this phenomenon. Whereas in 1997 only 50 species of NTM had been identified, now more than 125 have been...
title: Современные кредитные продукты
Creators: name: ELS IPR BOOKS
Publisher: name: Новосибирский государственный университет экономики и управления «НИНХ»
Year: 2020

description: В учебном пособии рассматриваются вопросы создания новых кредитных продуктов и продвижения их на рынке. Отдельный раздел посвящен розничным кредитным продуктам и законодательным основам регулирования правоотношений в процессе реализации их физическим лицам. Представлены виды и характеристики кредитных продуктов в разрезе типов организаций, оперирующих на кредитном рынке: банки, микрофинансовые организации, потребительские кооперативы. В пособии изложены характерные аспекты факторинговых и лизинговых сделок, традиционно относимых к новым кредитным продуктам. В завершающем разделе освещены практические основы реализации кредитных продуктов коммерческими банками, являющимися наиболее активными рыночными субъектами в сегменте кредитования.
Brocchia cinerea Visiani 1836
Creators: name: Clementi, Moreno
name: D'Antraccoli, Marco
name: Miola, Antonella
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Asterales
Asteraceae
Brocchia
Brocchia cinerea

description: Brocchia cinerea (Delile) Visiani (1836a: 219; also treated in Visiani 1836b: 35; 1836c: 68).
 Basionym:— Cotula cinerea Delile (1813: 275).
 Note:—This name is currently accepted (e.g. Euro+Med 2018).
description: Published as part of Clementi, Moreno, D'Antraccoli, Marco & Miola, Antonella, 2019, Nomenclatural and taxonomical notes on some taxa described by Roberto de Visiani from Egypt and Sudan, pp. 49-64 in Phytotaxa 399 (1) on page 60, DOI: 10.11646/phytotaxa.399.1.6, http://zenodo.org/record/13712994
LRP1 Regulates Retinal Angiogenesis by Inhibiting PARP-1 Activity and Endothelial Cell ProliferationSignificance
Creators: name: Mao, Hua
name: Davin Townley-Tilson,
name: Pi, Xinchun
name: Xie, Liang
name: Lockyer, Pamela
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: We recently demonstrated that low-density lipoprotein receptor related protein 1 (LRP1) is required for cardiovascular development in zebrafish. However, what role LRP1 plays in angiogenesis remains to be determined. To better understand the role of LRP1 in endothelial cell function, we investigated how LRP1 regulates mouse retinal angiogenesis.
The Impact of Antipsychotic Dose-Reduction and Discontinuation on Cognition, Functioning, Physical Health, and Relapse in Psychotic Illness: A Systematic Review
Creators: name: Stainton, Alexandra
name: Nicholas, Jennifer
name: Ellinghaus, Carli
name: Kapelles, Tayla
name: Mohammedally, Bibi
name: Gates, Jesse
name: Allott, Kelly
name: Killackey, Eóin
name: Speyer, Helene
name: Stürup, Anne
name: Albert, Nikolai
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Mental Disorders
subject: Psychiatry and Psychology
subject: Psychiatric and Mental Health
subject: Medicine and Health Sciences
subject: Mental and Social Health
subject: Antipsychotic Medication
subject: Cognition
subject: Discontinuation
subject: Dose Reduction
subject: Functional Outcomes
subject: Mental Health
subject: Physical Health
subject: Psychiatry
subject: Psychology
subject: FOS: Psychology
subject: Psychosis
subject: Psychotic Disorders
subject: Psychotic Relapse

description: This is the registration for the protocol of a systematic review which will examine the effects of antipsychotic dose reduction and discontinuation on cognitive, functional, physical health, and relapse outcomes in psychotic illness.
On boundedness of semistable sheaves
Creators: name: Langer, Adrian
Publisher: name: arXiv
Year: 2021
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: We give a new simple proof of boundedness of the family of semistable sheaves with fixed numerical invariants on a fixed smooth projective variety. In characteristic zero our method gives a quick proof of Bogomolov's inequality for semistable sheaves on a smooth projective variety of any dimension $\ge 2$ without using any restriction theorems.
description: v2: 12 pages, many changes improving readibility of the paper and making it more self-contained; added new restriction Theorem 3.7 on the projective space; added Appendix containing author's variant of proof of Bogomolov's inequality
Mice Expressing Low Levels of CalDAG-GEFI Exhibit Markedly Impaired Platelet Activation With Minor Impact on HemostasisHighlights
Creators: name: Paul, David S.
name: McKenzie, Steven E.
name: Cooley, Brian C.
name: Cowley, Dale O.
name: Bergmeier, Wolfgang
name: Piatt, Raymond
name: Parise, Leslie V.
name: Lee, Robert H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: OBJECTIVE: The tight regulation of platelet adhesiveness, mediated by the αIIbβ3 integrin, is critical for hemostasis and prevention of thrombosis. We recently demonstrated that integrin affinity in platelets is controlled by the guanine nucleotide exchange factor, CalDAG-GEFI (CD-GEFI), and its target, RAP1. In this study, we investigated whether low-level expression of CD-GEFI leads to protection from thrombosis without pathological bleeding in mice.

APPROACH AND RESULTS: Cdg1(low) mice were generated by knockin of human CD-GEFI cDNA into the mouse Cdg1 locus. CD-GEFI expression in platelets from Cdg1(low) mice was reduced by ≈90% when compared with controls. Activation of RAP1 and αIIbβ3 was abolished at low agonist concentrations and partially inhibited at high agonist concentrations in Cdg1(low) platelets. Consistently, the aggregation response of Cdg1(low) platelets was weaker than that of wild-type platelets, but more efficient than that observed in Cdg1(-/-) platelets. Importantly, Cdg1(low) mice were strongly protected from arterial and immune complex-mediated thrombosis, with only minimal impact on primary hemostasis.

CONCLUSIONS: Together, our studies suggest the partial inhibition of CD-GEFI function as a powerful new approach to safely prevent thrombotic complications.
title: The diagnostic impact of dynamic upright MRI for the assessment of cervical spine abnormalities.
Creators: name: Fotiadou, Anastasia
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Musculoskeletal spine
subject: MR
subject: Imaging sequences
subject: Education and training

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Cervical spine related symptoms are associated with changes in the size of the spinal canal, changes in the morphology of the intervertebral discs and relative translation between adjacent vertebrae as a result of gravity and dynamic...
Discrete-time Temporal Network Embedding via Implicit Hierarchical Learning in Hyperbolic Space
Creators: name: Yang, Menglin
name: Zhou, Min
name: Kalander, Marcus
name: Huang, Zengfeng
name: King, Irwin
Publisher: name: arXiv
Year: 2021
Subjects: subject: Social and Information Networks (cs.SI)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Representation learning over temporal networks has drawn considerable attention in recent years. Efforts are mainly focused on modeling structural dependencies and temporal evolving regularities in Euclidean space which, however, underestimates the inherent complex and hierarchical properties in many real-world temporal networks, leading to sub-optimal embeddings. To explore these properties of a complex temporal network, we propose a hyperbolic temporal graph network (HTGN) that fully takes advantage of the exponential capacity and hierarchical awareness of hyperbolic geometry. More specially, HTGN maps the temporal graph into hyperbolic space, and incorporates hyperbolic graph neural network and hyperbolic gated recurrent neural network, to capture the evolving behaviors and implicitly preserve hierarchical information simultaneously. Furthermore, in the hyperbolic space, we propose two important modules that enable HTGN to successfully model temporal networks: (1) hyperbolic temporal contextual self-attention (HTA) module to attend to historical states and (2) hyperbolic temporal consistency (HTC) module to ensure stability and generalization. Experimental results on multiple real-world datasets demonstrate the superiority of HTGN for temporal graph embedding, as it consistently outperforms competing methods by significant margins in various temporal link prediction tasks. Specifically, HTGN achieves AUC improvement up to 9.98% for link prediction and 11.4% for new link prediction. Moreover, the ablation study further validates the representational ability of hyperbolic geometry and the effectiveness of the proposed HTA and HTC modules.
description: KDD2021; V2: fixed some typos
Molecular Characterization of the Lipid Genome-Wide Association Study Signal on Chromosome 18q11.2 Implicates HNF4A-Mediated Regulation of the TMEM241 GeneHighlights
Creators: name: Ordóñez-Sánchez, Maria-Luisa
name: Bhagat, Yash
name: Aguilar-Salinas, Carlos A.
name: Rodríguez, Alejandra
name: Ko, Arthur
name: Mohlke, Karen L.
name: Miao, Zong
name: Gonzalez, Luis
name: Arellano-Campos, Olimpia
name: Pajukanta, Päivi
name: Muñoz-Hernández, Linda L.
name: Alvarez, Marcus
name: Tusie-Luna, Teresa
name: Rodriguez-Guillen, Rosario
name: Nikkola, Elina
name: Laakso, Markku
name: Cruz-Bautista, Ivette
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: We recently identified a locus on chromosome 18q11.2 for high serum triglycerides (TGs) in Mexicans. We hypothesize that the lead GWAS single nucleotide polymorphism (SNP) rs9949617, or its linkage disequilibrium (LD) proxies, regulate one of the 5 genes in the TG-associated region.
title: Brainstem and Cerebellum Lesions in Adults: Pearls to the diagnosis with MRI.
Creators: name: Nova Vaca, Diego
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Inflammation
subject: Infection
subject: Localisation
subject: Imaging sequences
subject: Diagnostic procedure
subject: MR-Spectroscopy
subject: MR-Diffusion/Perfusion
subject: MR
subject: Anatomy
subject: Neuroradiology brain
subject: CNS
subject: Ischaemia / Infarction

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To review the normal radiological anatomy of the brainstem and cerebellum. To illustrate the MR imaging features of infratentorial lesions in the adulthood. To describe an imaging strategy to accurately diagnose each case, based on MRI appearance...
CLAP: A New Algorithm for Promise CSPs
Creators: name: Ciardo, Lorenzo
name: Živný, Stanislav
Publisher: name: arXiv
Year: 2021
Subjects: subject: Computational Complexity (cs.CC)
subject: Discrete Mathematics (cs.DM)
subject: Data Structures and Algorithms (cs.DS)
subject: FOS: Computer and information sciences

description: We propose a new algorithm for Promise Constraint Satisfaction Problems PCSPs). It is a combination of the $\textbf{C}$onstraint Basic $\textbf{L}$P relaxation and the $\textbf{A}$ffine I$\textbf{P}$ relaxation (CLAP). We give a characterisation of the power of CLAP in terms of a minion homomorphism. Using this characterisation, we identify a certain weak notion of symmetry which, if satisfied by infinitely many polymorphisms of PCSPs, guarantees tractability. We demonstrate that there are PCSPs solved by CLAP that are not solved by any of the existing algorithms for PCSPs; in particular, not by the BLP+AIP algorithm of Brakensiek et al. [SICOMP'20] and not by a reduction to tractable finite-domain CSPs.
description: Full version of a SODA 2022 paper
A scoping review of nurse- and midwife-led randomized controlled trials in Australia and New Zealand: a protocol
Creators: name: Fish, Jennifer
name: Rickard, Claire
name: Gray, Richard
name: Middleton, Sandy
name: Homer, Caroline
name: Keogh, Samantha
name: Leslie, Gavin
name: Nemeh, Fiona
name: Neville, Stephen
name: Sharplin, Greg
name: Yates, Patsy
name: Whitehead, Lisa
name: Eckert, Marion
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Perioperative, Operating Room and Surgical Nursing
subject: Family Practice Nursing
subject: Medicine and Health Sciences
subject: Maternal, Child Health and Neonatal Nursing
subject: Geriatric Nursing
subject: Public Health and Community Nursing
subject: Psychiatric and Mental Health Nursing
subject: Other Nursing
subject: Nursing
subject: FOS: Health sciences
subject: Nursing Midwifery
subject: Australia
subject: Clinical Trial
subject: Midwifery
subject: New Zealand
subject: Nursing
subject: Randomized Controlled Trial
subject: Scoping Review

description: This registration is for a scoping review project charting nurse- and midwife-led randomized controlled trials (RCTs) in Australia and New Zealand, which is guided by the Joanna Briggs Institute (JBI) framework for conducting a scoping review.
Measurement-assisted Landau-Zener transitions
Creators: name: Pechen, A. N.
name: Trushechkin, A. S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Nonselective quantum measurements, i.e., measurements without reading the results, are often considered as a resource for manipulating quantum systems. In this work, we investigate optimal acceleration of the Landau-Zener (LZ) transitions by non-selective quantum measurements. We use the measurements of a population of a diabatic state of the LZ system at certain time instants as control and find the optimal time instants which maximize the LZ transition. We find surprising nonmonotonic behavior of the maximal transition probability with increase of the coupling parameter when the number of measurements is large. This transition probability gives an optimal approximation to the fundamental quantum Zeno effect (which corresponds to continuous measurements) by a fixed number of discrete measurements. The difficulty for the analysis is that the transition probability as a function of time instants has a huge number of local maxima. We resolve this problem both analytically by asymptotic analysis and numerically by the development of efficient algorithms mainly based on the dynamic programming. The proposed numerical methods can be applied, besides this problem, to a wide class of measurement-based optimal control problems.
description: 17 pages, 7 figures
Confluence of hypergeometric functions and integrable hydrodynamic type systems
Creators: name: Kodama, Y.
name: Konopelchenko, B.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: It is known that a large class of integrable hydrodynamic type systems can be constructed through the Lauricella function, a generalization of the classical Gauss hypergeometric function. In this paper, we construct novel class of integrable hydrodynamic type systems which govern the dynamics of critical points of confluent Lauricella type functions defined on finite dimensional Grassmannian Gr(2,n), the set of 2xn matrices of rank two. Those confluent functions satisfy certain degenerate Euler-Poisson-Darboux equations. It is also shown that in general, hydrodynamic type system associated to the confluent Lauricella function is given by an integrable and non-diagonalizable quasi-linear system of a Jordan matrix form. The cases of Grassmannian Gr(2,5) for two component systems and Gr(2,6) for three component systems are considered in details.
description: 22 pages, PMNP 2015, added some comments and references
title: Something lost along the way : changing patterns of leadership in Scottish residential schools
Creators: name: Smith, Mark
Publisher: name: Strathprints - University of Strathclyde
Year: 2015

description: This article considers changing patterns of leadership in Scottish residential schools through the life histories of those who have undertaken leadership roles in the sector over the past 50 years. A case is made for the relevance of life history methods in offering a rich picture of the lived realities of residential child care over time. The stories are analysed to identify some features of leadership in the schools, locating these within the changing external policy environment. General trends from innovation towards regulation and from personalised towards standardised leadership practices are identified. The article employs wider theoretical insights to offer some evaluative comment on these changes, concluding that the path has not necessarily been one of untrammelled progress and that much of the value base and creativity that characterised earlier expressions of leadership has been lost along the way.
Talking about money: reducing government spending on bankruptcy procedures of 'empty boxes'? A TDABC-analysis
Creators: name: Vandenbossche, Gauthier
Publisher: name: Zenodo
Year: 2023

description: Talking about money: reducing government spending on bankruptcy procedures of ‘empty boxes’? A TDABC-analysis The purpose of a bankruptcy procedure is to place the debtor’s assets under the control of a trustee in bankruptcy. The trustee has a central role in this procedure. Its task is to administer the estate, to liquidate the assets and to distribute any liquidation proceeds among the creditors. Such a complex procedure entails a certain workload (activities) and costs, in the form of the intervention of the trustee and other judicial actors. Despite no systematic data being collected on this, in practice it often appears that undertakings in a state of bankruptcy have no significant assets to distribute among creditors. If it turns out that the assets are that insufficient that even the costs of administering and liquidation of the estate cannot be covered, Belgian insolvency law provides that the bankruptcy procedure can be closed for lack of assets or for insufficient assets. This decision by the court entails the dissolution of the legal entity and the immediate closure of the liquidation process. It is argued that the bankruptcy of such 'empty boxes' costs the courts a lot of time and effort and apparently costs a lot of money for the State. In the context of efficient management of scarce human and financial resources of the State, such legal entities should be liquidated at the lowest possible cost. For this reason, the recent draft law transposing Directive (EU) 2019/1023 into Belgian insolvency law makes it possible to transfer from bankruptcy to judicial dissolution and immediate closure of the liquidation, without appointing a trustee. However, that debate is lacking objective figures. The question is whether bankruptcy proceedings, with the appointment of a trustee, really entail such a high cost for the Belgian state. For bankruptcies where assets are not sufficient to pay the trustee's fees, the Belgian State, instead of the estate, pays a lump-sum fee of 1,215.51 euros. Using the Time Driven Activity Based Costing (TDABC) economic costing model, the actual cost of the workload and time spent by the trustee in bankruptcy proceedings can be calculated. Based on this method, a real economic cost price can be calculated for (the time spent on) the legally defined tasks (activities such as drawing up the inventory, verifying claims and drafting reports) that the trustee carries out. All this should allow to examine the real added value of the trustee in a bankruptcy case that is closed due to insufficient assets. Only in this way can a sound cost-benefit analysis be made of the trustee's intervention. Innovatively, the TDABC model is thereby applied to legal proceedings.
The GHS and other correlation inequalities for the two-star model
Creators: name: Bianchi, Alessandra
name: Collet, Francesca
name: Magnanini, Elena
Publisher: name: arXiv
Year: 2021
Subjects: subject: Probability (math.PR)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: Primary 05C80, 60K35. Secondary 82B26

description: We consider the two-star model, a family of exponential random graphs indexed by two real parameters, $h$ and $α$, that rule respectively the total number of edges and the mutual dependence between them. Borrowing tools from statistical mechanics, we study different classes of correlation inequalities for edges, that naturally emerge while taking the partial derivatives of the (finite size) free energy. In particular, if $α, h\ge 0$, we derive first and second order correlation inequalities and then prove the so-called GHS inequality. As a consequence, under the above conditions on the parameters, the average edge density turns out to be an increasing and concave function of the parameter $h$, at any fixed size of the graph. Some of our results can be extended to more general classes of exponential random graphs.
description: 17 pages, 1 figure
title: Revisited ultrasound of the spleen: common and uncommon findings
Creators: name: Amorim, João
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Acute
subject: Drainage
subject: Diagnostic procedure
subject: Biopsy
subject: Ultrasound
subject: Spleen
subject: Abdomen
subject: Abscess
subject: Lymphoma

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To identify and describe the sonographic appearance of common and uncommon splenic lesions. To discuss ultrasound strengths and limitations in detecting spleen abnormalities. To describe percutaneous ultrasound guided biopsy of splenic mass and...
Valley excitons in two-dimensional semiconductors
Creators: name: Yu, Hongyi
name: Cui, Xiaodong
name: Xu, Xiaodong
name: Yao, Wang
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Monolayer group-VIB transition metal dichalcogenides have recently emerged as a new class of semiconductors in the two-dimensional limit. The attractive properties include: the visible range direct band gap ideal for exploring optoelectronic applications; the intriguing physics associated with spin and valley pseudospin of carriers which implies potentials for novel electronics based on these internal degrees of freedom; the exceptionally strong Coulomb interaction due to the two-dimensional geometry and the large effective masses. The physics of excitons, the bound states of electrons and holes, has been one of the most actively studied topics on these two-dimensional semiconductors, where the excitons exhibit remarkably new features due to the strong Coulomb binding, the valley degeneracy of the band edges, and the valley dependent optical selection rules for interband transitions. Here we give a brief overview of the experimental and theoretical findings on excitons in two-dimensional transition metal dichalcogenides, with focus on the novel properties associated with their valley degrees of freedom.
description: Topical review, published online on National Science Review in Jan 2015
Pilih Pilah Strategi Perusahan Multinasional Memasuki Pasar
Creators: name: Bertha, Giovanny
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Business
subject: Education

description: Ada berbagai macam jenis strategi penetrasi yang dilakukan perusahaan multinasional untuk memasuki pasar. Dalam kasus industri alat medis Indonesia, ada beberapa strategi yang cukup dominan. Perusahaan multinasional tidak hanya memilih satu jenis strategi aliansi tetapi juga menggabungkan beberapa dari strateginya. Namun perusahaan juga bisa memilah manakah strategi yang cocok dengan tujuan perusahaan sehingga semakin mudah mengakses pasar.
title: Imaging findings of breast implants and its complications
Creators: name: Garrido Bermejo, José Carlos
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Prostheses
subject: Education
subject: Ultrasound
subject: MR
subject: Mammography
subject: Breast

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To review the normal and abnormal imaging findings in patients following breast augmentation with implants, with special focus on implant...
Walking and Calcified Atherosclerotic Plaque in the Coronary ArteriesHighlights: The National Heart, Lung, and Blood Institute Family Heart Study
Creators: name: Ellison, R. Curtis
name: Heiss, Gerardo
name: Djoussé, Luc
name: Pankow, James S.
name: Carr, J. Jeffrey
name: Arnett, Donna K.
name: Hunt, Steven C.
name: Gaziano, J. Michael
name: Patel, Yash
name: Imran, Tasnim F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Studies have reported mixed findings on the association between physical activity and subclinical atherosclerosis. We sought to examine whether walking is associated with prevalent coronary artery calcification (CAC) and aortic calcification (AC).
KINETIC AND MECHANISTIC CHARACTERIZATION OF HUMAN SULFOTRANSFERASES (SULT2B1b AND SULT1A1): DRUG TARGETS TO TREAT CANCERS
Creators: name: Kulathunga, Yamasingha Pathiranage
Publisher: name: Purdue University Graduate School
Year: 2023
Subjects: Enzymes
Analytical spectrometry

description: Sulfonation is a widespread biological reaction catalyzed by a supergene family of enzymes called sulfotransferases (SULTs). SULTs utilize 3’-phosphoadenosine-5’-phospho-sulfate (PAPS) as the universal sulfonate donor to conjugate with a diverse range of endo- and xenobiotic substrates, including neurotransmitters, hormones, and drugs resulting in altering their biological activity. This reaction serves as a major detoxification pathway as conjugation with a sulfonate group renders substrates more hydrophilic and facilitates excretion. Therefore, this process is responsible for reducing the bioavailability of some drugs. In some cases, sulfo-conjugation causes the bio-activation of pro-mutagens and pro-carcinogens, leading to SULTs being risk factors in some cancers. Despite the biological relevance, understanding of this family of enzymes is still scarce. One SULT member that is the focus of the studies described herein is human sulfotransferase 2B1b (SULT2B1b), which had been identified as a potential drug target in prostate cancer. However, the inconsistency in reported kinetic data obtained using radiolabeled assays and the lack of robust assays have become significant limitations for SULT2B1b-targeted drug discovery studies. A label-free assay was developed to bridge this knowledge gap that directly quantifies SULT2B1b sulfonated products. This novel assay utilized high-throughput technology based on Desorption Electrospray Ionization Mass Spectrometry (DESI-MS). Results obtained from the DESI-MS-based assay were compared with those from a fluorometric, coupled-enzyme assay already developed in the Mesecar lab. Both methods provided consistent kinetic data for the reaction of SULT2B1b. Therefore, this novel assay is promising for the application of drug discovery efforts aiming at identifying SULT2B1b inhibitors. The other SULT member studied and described herein is human sulfotransferase 1A1 (SULT1A1), one of humans' most vital detoxifying and drug-metabolizing SULT isoforms that can also be a potential drug target in some cancers. The detailed kinetic mechanism of SULT1A1 was elucidated using steady-state kinetic, product inhibition, dead-end inhibition, and X-crystallographic studies. to gain insights into the role of this enzyme in detoxification, drug metabolism, and the development of inhibitors.
Alk2/ACVR1 and Alk3/BMPR1A Provide Essential Function for Bone Morphogenetic Protein–Induced Retinal AngiogenesisHighlights
Creators: name: Lee, Heon-Woo
name: Bautch, Victoria L.
name: Ka, Jun
name: Jin, Suk-Won
name: Dunworth, William P.
name: Kaartinen, Vesa M.
name: Meadows, Stryder
name: Ola, Roxana
name: Chong, Diana C.
name: Eichmann, Anne
name: Cleaver, Ondine
name: Qyang, Yibing
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: OBJECTIVE: Increasing evidence suggests that bone morphogenetic protein (BMP) signaling regulates angiogenesis. Here, we aimed to define the function of BMP receptors in regulating early postnatal angiogenesis by analysis of inducible, endothelial-specific deletion of the BMP receptor components Bmpr2 (BMP type 2 receptor), Alk1 (activin receptor-like kinase 1), Alk2, and Alk3 in mouse retinal vessels.

APPROACH AND RESULTS: Expression analysis of several BMP ligands showed that proangiogenic BMP ligands are highly expressed in postnatal retinas. Consistently, BMP receptors are also strongly expressed in retina with a distinct pattern. To assess the function of BMP signaling in retinal angiogenesis, we first generated mice carrying an endothelial-specific inducible deletion of Bmpr2. Postnatal deletion of Bmpr2 in endothelial cells substantially decreased the number of angiogenic sprouts at the vascular front and branch points behind the front, leading to attenuated radial expansion. To identify critical BMPR1s (BMP type 1 receptors) associated with BMPR2 in retinal angiogenesis, we generated endothelial-specific inducible deletion of 3 BMPR1s abundantly expressed in endothelial cells and analyzed the respective phenotypes. Among these, endothelial-specific deletion of either Alk2/acvr1 or Alk3/Bmpr1a caused a delay in radial expansion, reminiscent of vascular defects associated with postnatal endothelial-specific deletion of BMPR2, suggesting that ALK2/ACVR1 and ALK3/BMPR1A are likely to be the critical BMPR1s necessary for proangiogenic BMP signaling in retinal vessels.

CONCLUSIONS: Our data identify BMP signaling mediated by coordination of ALK2/ACVR1, ALK3/BMPR1A, and BMPR2 as an essential proangiogenic cue for retinal vessels.
title: Can radiology make a difference in Cytoreductive surgery?
Creators: name: Lazu, Camelia
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Multidisciplinary cancer care
subject: Metastases
subject: Surgery
subject: Localisation
subject: Computer Applications-Detection, diagnosis
subject: MR
subject: CT
subject: Pelvis
subject: Oncology
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To know what cytoreductive surgery (CRS) is Patterns of peritoneal spread of tumor in the abdomen and pelvis Imaging techniques in peritoneal...
Evaluation of Schwartz Rounds in Children's services
Creators: name: Bezeczky, Zoe
name: Wilkins, David
name: Forrester, Donald
name: Thompson, Sarah
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social Work
subject: FOS: Sociology
subject: Social and Behavioral Sciences

description: This protocol supersedes a previous protocol published in March 2019. This is due to the addition of more local authorities to the trial in a second phase of data collection in order to increase statistical power after there were challenges with initial recruitment. In addition, in phase two there has been a significant change in the mode of delivery of the intervention. Due to the Covid-19 pandemic, rounds cannot be delivered face-to-face and so the five new authorities to join the trial will deliver their rounds virtually.
The Fast Evolving, Tremendous and Blue Superoutburst in ASASSN-21au Reveals a Dichotomy in the Outbursts of Long-period AM CVns
Creators: name: Sandoval, L. E. Rivera
name: Heinke, C. O.
name: Hameury, J. M.
name: Cavecchi, Y.
name: Vanmunster, T.
name: Tordai, T.
name: Romanov, F.
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: ASASSN-21au is an ultracompact accreting white dwarf binary (AM CVn) with a period of approx. 58 min. Using multiwavelength observations of the system, we discovered a dichotomy in the behavior of outbursts in AM CVns. The binary showed an initial brightness increase which lasted for at least 82 days, followed by an additional increase which lasted 2 weeks. Afterwards ASASSN-21au went into superoutburst with a total duration of 19 days, showing an amplitude with respect to quiescence of approx. 7.5 mags in g, with a precursor and an echo outburst. A correlation between X-rays, UV and optical was identified for the first time in an AM CVn during this stage. The color evolution of ASASSN-21au indicates that during the superoutburst the dominant component was the accretion disk. The short duration, large amplitude and color evolution of the superoutburst agree with expectations from the disk instability model. These characteristics are opposite to the ones observed in SDSS J080710+485259 and SDSS J113732+405458, which have periods of approx. 53 min and 60 min, respectively. The initially slow brightness increase in the light curve of ASASSN-21au and the behavior after the superoutburst favors a scenario in which changes in the mass-transfer rate led to disk instabilities, while the outburst mechanism of SDSS J080710+485259 and SDSS J113732+405458 has been attributed to enhanced mass-transfer alone. Further observations are needed to understand the origin of this dichotomy.
description: Published in ApJ in February 2022
Type I+III Seesaw Mechanism and CP Violation for Leptogenesis
Creators: name: Franco, Edison T.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: A seesaw mechanism is presented in the neutrino sector and a new phase of CP violation ($α$) emerges in the interplay between the type-I and type-III seesaw schemes. This phase is inside the mixing term, and thus it cannot be rotated away in the Yukawa Lagrangian and, therefore, the heavy symmetry states cannot be in a diagonal weak basis in the broken phase. Some particular descriptions are analyzed suggesting that if the usual Yukawa couplings are suppressed, leptogenesis still occurs due to a new interacting vertex with fermion triplet $T$, fermion singlets $N$, and an ad-hoc scalar triplet, $Σ$, which now is included to mediate the interactions. The evaluated CP violation is enough to generate the observed matter-antimatter asymmetry even in the minimal $1N+1T$ case (independently of $α$) or in the $2N+1T$ approach (controlled by $α$). The latter introduces more CP contributions to leptogenesis due to new diagrams which are now possible even with the suppressed imaginary part of the standard Yukawa couplings and can induce the observed baryon-to-photon ratio.
description: 9 pages, 10 figures; title changed, typos corrected, matches with the published version in PRD
Apargia annua Visiani 1836
Creators: name: Clementi, Moreno
name: D'Antraccoli, Marco
name: Miola, Antonella
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Asterales
Asteraceae
Apargia
Apargia annua

description: Apargia annua Visiani (1836a: 222; also treated in Visiani 1836b: 38; 1836c: 69)
 Locus classicus: —“in AEgypto”.
 Note:—No specimens could be located pertaining to this taxon. This name has been considered a synonym of Scorzoneroides hispidula (Delile) Greuter & Talavera (in Greuter et al. 2006: 691; basionym: Crepis hispidula Delile 1813: 261; see e.g. Boulos 2002), which we could not conclusively confirm.
description: Published as part of Clementi, Moreno, D'Antraccoli, Marco & Miola, Antonella, 2019, Nomenclatural and taxonomical notes on some taxa described by Roberto de Visiani from Egypt and Sudan, pp. 49-64 in Phytotaxa 399 (1) on page 60, DOI: 10.11646/phytotaxa.399.1.6, http://zenodo.org/record/13712994
title: A pictorial review depicting the role of MRI in assessing response to neoadjuvant chemoradiotherapy in locally advanced rectal cancers and in planning surgical resection
Creators: name: Paul, Peter
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: MR
subject: Oncology
subject: Pelvis
subject: Gastrointestinal tract
subject: Comparative studies
subject: Cancer

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: 1. To depict the role of MRI in evaluating response to neo-adjuvant chemo- radiotherapy (NACT-RT) in locally advanced rectal cancer. 2. To describe the role of post NACT-RT MRI in planning surgical...
Quality of Reporting in Chiropractic Mixed Methods Research: A Methodological Review
Creators: name: Emary, Peter
name: Stuber, Kent
name: Oremus, Mark
name: Mbuagbaw, Lawrence
name: Couban, Rachel
name: Ciraco, Carla
name: Nash, Jennifer
name: Nolet, Paul
name: Busse, Jason
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: Chiropractic
subject: Methodological Review
subject: Mixed Methods Research
subject: Reporting Quality

description: The purpose of this methodological review is to examine the reporting quality of chiropractic mixed methods research articles published in the biomedical and allied health literature.
Natural parameterized quantum circuit
Creators: name: Haug, Tobias
name: Kim, M. S.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Noisy intermediate scale quantum computers are useful for various tasks such as state preparation and variational quantum algorithms. However, the non-Euclidean quantum geometry of parameterized quantum circuits is detrimental for these applications. Here, we introduce the natural parameterized quantum circuit (NPQC) that can be initialised with a Euclidean quantum geometry. The initial training of variational quantum algorithms is substantially sped up as the gradient is equivalent to the quantum natural gradient. Further, we show how to estimate the parameters of the NPQC by sampling the circuit, which could be used for benchmarking or calibrating NISQ hardware. For a general class of quantum circuits, the NPQC has the minimal quantum Cramér-Rao bound which highlights its potential for quantum metrology. Finally, we show how to generate arbitrary superpositions of two states with the NPQCs for state preparation tasks. Our results can be used to enhance currently available quantum processors.
description: 14 pages, 10 figures
Quantum Physics in Space
Creators: name: Belenchia, Alessio
name: Carlesso, Matteo
name: Bayraktar, Ömer
name: Dequal, Daniele
name: Derkach, Ivan
name: Gasbarri, Giulio
name: Herr, Waldemar
name: Li, Ying Lia
name: Rademacher, Markus
name: Sidhu, Jasminder
name: Oi, Daniel KL
name: Seidel, Stephan T.
name: Kaltenbaek, Rainer
name: Marquardt, Christoph
name: Ulbricht, Hendrik
name: Usenko, Vladyslav C.
name: Wörner, Lisa
name: Xuereb, André
name: Paternostro, Mauro
name: Bassi, Angelo
Publisher: name: arXiv
Year: 2021
Subjects: subject: Quantum Physics (quant-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Experiment (hep-ex)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: Advances in quantum technologies are giving rise to a revolution in the way fundamental physics questions are explored at the empirical level. At the same time, they are the seeds for future disruptive technological applications of quantum physics. Remarkably, a space-based environment may open many new avenues for exploring and employing quantum physics and technologies. Recently, space missions employing quantum technologies for fundamental or applied studies have been proposed and implemented with stunning results. The combination of quantum physics and its space application is the focus of this review: we cover both the fundamental scientific questions that can be tackled with quantum technologies in space and the possible implementation of these technologies for a variety of academic and commercial purposes.
title: Shoulder Ultrasound : how we do it - a step by step guide
Creators: name: de Carvalho, Rúben
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Education and training
subject: Technical aspects
subject: Diagnostic procedure
subject: Ultrasound
subject: Musculoskeletal joint

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To depict and explain in a step-by-step guide the technique of shoulder ultrasound, and review the fundamental anatomical structures and potential pitfalls and artefacts. To review and illustrate the most important pathologies found at ultrasound...
Optimizing Verification of RTL Designs Using Reinforcement Learning Methods
Creators: name: Ohana, Eric
Publisher: name: Universität Bielefeld
Year: 2023
Subjects: subject: 000

description: The integrated circuit scale integration evolution in the last sixty years has today enabled the design of highly complex digital systems on a single semiconductor chip. Due to the great cost of semiconductor chip projects, ensuring these digital systems work first-time is paramount. Digital verification paradigms and techniques have therefore also evolved in parallel with the scale integration evolution. Today the most prevalent paradigm for digital designs modelled at the Register Transfer Logic (RTL) level is the ‘simulation based constrained random coverage driven functional verification’. This paradigm is abbreviated as CFV in this research. While greatly enhancing the verification process for the bulk of the RTL design, reaching full functional coverage, a necessary step for verification closure, remains a major bottleneck, mainly due to the manual intervention in the process. The present research tackles this issue by exploring the use and the integration of deep reinforcement learning techniques in a CFV environment. The research makes use of a deep learning approach to a Q-Learning variant, the same approach as used in the work by DeepMind Technologies to play Atari games. The RTL design used throughout the research is an LZW encoder as it is on one hand sufficiently complex to be representative, and on the other hand, it allows for an unambiguous assessment of the novel approach on the functional coverage closure process. I show that the use and integration of deep Q-Learning based techniques in a CFV environment is greatly beneficial in generating scenarios targeting functional coverage holes. It also allows for the complete automation of the functional coverage closure process for the LZW encoder, paving the way to broaden its use during the verification of semiconductor projects.
title: Typical and atypical radiologic presentation of pulmonary metastases
Creators: name: Bystrická, Nadežda
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Oncology
subject: Thorax
subject: Lung
subject: CT
subject: Digital radiography
subject: Conventional radiography
subject: Staging
subject: Diagnostic procedure
subject: Cancer
subject: Metastases

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: • to describe the imaging features of typical pulmonary metastases • to illustrate the spectrum of radiologic findings seen in atypical pulmonary metastases • to outline the spectrum of diseases that may mimic metastatic lung involvement in...
DBA/2J Haplotype on Distal Chromosome 2 Reduces Mertk Expression, Restricts Efferocytosis, and Increases Susceptibility to AtherosclerosisHighlights
Creators: name: Makhanova, Natalia
name: Maeda, Nobuyo
name: Kayashima, Yukako
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: OBJECTIVE: Arch atherosclerosis 4 (Aath4) is a quantitative trait locus for atherosclerotic plaque formation in the inner curve of the aortic arch previously identified in an F2 cross of Apoe-/- mice on DBA/2J and 129S6 backgrounds. C-mer proto-oncogene tyrosine kinase (Mertk), coding for a ligand-activated transmembrane tyrosine kinase, is a candidate gene within the same chromosomal region. Our objective was to determine whether strain differences in Mertk influence plaque formation.

APPROACH AND RESULTS: To dissect the strain effects of Mertk on atherosclerosis, we first established a congenic mouse line (Aath4aDBA/DBA ) in which a 5' region of Aath4 of DBA/2J, including Mertk, was backcrossed onto a 129S6-Apoe-/- background. The resulting Aath4aDBA/DBA male mice developed significantly larger plaques compared with control mice (Aath4a129/129 ), proving that the DBA/2J allele of Aath4a is proatherogenic. Thioglycollate-elicited peritoneal macrophages from Aath4aDBA/DBA mice express less than 50% of Mertk mRNA and cell-surface MERTK protein compared with those from the control mice. Moreover, both large and small peritoneal Aath4aDBA/DBA macrophages showed reduced phagocytosis of apoptotic cells. When Mertk cDNAs from 129S6 and DBA/2J mice were overexpressed in HEK293T (human embryonic kidney 293T) cells, phagocytosis of apoptotic cells was equally enhanced in direct proportion to Mertk levels, indicating that phagocytosis is modulated by the amount of MERTK, but that it is not affected by MERTK amino acid differences between 129S6 and DBA/2J.

CONCLUSIONS: Reduced transcription of Mertk, rather than differences in MERTK protein structure, determines the reduced efficiency of apoptotic cell clearance in the Aath4aDBA/DBA mice, which, in turn, contributes to their increased susceptibility to atherosclerosis.
Conceptualisations of distributed leadership in perception studies of post-primary school teachers and leaders. A Scoping Review Protocol.
Creators: name: Hickey, Niamh
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Educational Leadership
subject: Education

description: This is the registration of a protocol for a scoping review titled "Conceptualisations of distributed leadership in perception studies of post-primary school teachers and leaders. A Scoping Review". The attached file contains the protocol.