cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Whole genome sequencing of Venturia pirina enables a comparison of effectomes of two fungal fruit pathogens
Creators: name: Jones, Daniel Frank
Publisher: name: La Trobe
Year: 2023

description: This thesis investigates the genetic basis of infection and host specificity in the fungal pathogen Venturia pirina. A de novo assembly of the V. pirina genome was used to predict genes thought to be involved in infection and host specificity: “effector” genes; this represents the first genome sequence for this species. Predicted genes in V. pirina were compared to predicted genes in the related species Venturia inaequalis: a species with a similar host, life cycle, and mode of infection, but with different host specificity (V. pirina infects European pear: V. inaequalis infects apple). The suite of effector genes (the “effectome”) was derived for both species using de novo gene prediction programs, identification of secretion motifs, and by identification of known effector motifs. Unique genes for both species were identified, and used as targets in a PCR test designed to distinguish the species for the purposes of biosecurity surveillance. In many cases, gene loss or gene duplication has resulted in a different suite of potential effector genes for each species, which may be the basis of host specificity. Secreted proteins from V. pirina were extracted from an in vitro growth model that is designed to simulate leaf infections, and the presence of secreted proteins inferred by mass spectroscopy and by reference to the genome. This provided in vitro validation for in silico gene predictions. Furthermore, data from mass spectroscopy was used to refine gene predictions for small, secreted proteins that are difficult to predict with current gene prediction methods.

Submission note: A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the Botany Department, School of Life Sciences, Faculty of Science, Technology and Engineering, La Trobe University, Bundoora.
(201089) Alexander Stevenson Blair
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Exotic orbits due to spin-spin coupling around Kerr black holes
Creators: name: Han, Wen-Biao
name: Yang, Shu-Cheng
Publisher: name: arXiv
Year: 2016
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We report exotic orbital phenomena of spinning test particles orbiting around a Kerr black hole, i.e., some orbits of spinning particles are asymmetrical about the equatorial plane. When a nonspinning test particle orbits around a Kerr black hole in a strong field region, due to relativistic orbital precessions, the pattern of trajectories is symmetrical about the equatorial plane of the Kerr black hole. However, the patterns of the spinning particles' orbit are no longer symmetrical about the equatorial plane for some orbital configurations and large spins. We argue that these asymmetrical patterns come from the spin-spin interactions between spinning particles and Kerr black holes, because the directions of spin-spin forces can be arbitrary, and distribute asymmetrically about the equatorial plane.
description: 15 pages, 20 figures
Nodular lymphocyte predominant Hodgkin lymphoma: Experience of Polish Pediatric Leukemia/Lymphoma Study Group
Creators: name: Klekawka, Tomasz
name: Balwierz, Walentyna
name: Brozyna, Agnieszka
name: Chaber, Radoslaw
name: Dadela-Urbanek, Agnieszka
name: Koltan, Andrzej
name: Kwasnicka, Justyna
name: Mitura-Lesiuk, Malgorzata
name: Muszynska-Roslan, Katarzyna
name: Przybyszewski, Borys
name: Ruranska, Iwona
name: Smalisz, Katarzyna
name: Mizia-Malarz, Agnieszka
name: Stachowicz-Stencel, Teresa
name: Stolarska, Malgorzata
name: Wziatek, Agnieszka
name: Zielezinska, Katarzyna
name: Skoczen, Szymon
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Hematology

description: Nodular Lymphocyte Predominant Hodgkin Lymphoma (NLPHL) is a rare clinical entity. To investigate NLPHL clinical course and treatment a survey was performed within Polish Pediatric Leukaemia/Lymphoma Study Group (PPLLSG) participating centers. A questionnaire was sent to all participating centers and analysis of clinical data was performed. From 2010 to 2019, 19 pediatric patients with confirmed NLPHL were registered in Poland. Median age of patients was 12.2 (5.5 − 17.8) years. NLPHL occurred mainly in males (n = 17). Most of the patients (n = 16) had early stage disease – Stage I (n = 6) and stage II (n = 10). Four of the six patients with stage I disease (I A, n = 5; I B, n = 1) underwent complete primary resection. One of these relapsed and was treated with CVP (cyclophosphamide, vinblastine, prednisone) chemotherapy. Two other patients who were not resected completely received CVP chemotherapy and no relapses were observed. Thirteen patients presented with unresectable disease. Of these, eight received three CVP chemotherapy cycles, and five were treated with other chemotherapy regimens. Three relapses were observed and these patients were further treated with chemotherapy and rituximab. One patient underwent autologous stem cell transplantation (auto-SCT). All patients remain alive. Five-year progression-free survival and overall survival for the entire group of patients was 81.6% and 100%, respectively. NLPHL treatment results are consistent with results noted in other countries. Early stage patients have very good outcomes with surgery and observation or low intensity chemotherapy, but this approach may be insufficient in advanced disease.
(201094) David Barclay Bevan
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
In the midst of the world: realism in the novels of Michel Houellebecq
Creators: name: Jack, David William
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: This thesis argues for the realism of the novels of Michel Houellebecq. The purpose of this thesis is to address the gap in scholarship which has tended to focus on the content of Houellebecq’s novels, often at the expense of form. This thesis primarily considers the development of realism as a literary mode in Houellebecq’s novels. It thus considers closely three of Houellebecq’s early novels, Extension du domaine de la lutte, Les Particules élémentaires, and Plateforme; however Houellebecq’s other works, including fiction, non-fiction and poetry are cited where necessary, to support claims about his realism. The thesis considers the origins of Houellebecq’s realism in his contradictory relationship to the world (both au milieu and contra), his personal experiences of the world post-1968, and his rediscovery of Balzac. It argues that Balzac – and not Zola – is the true precursor to Houellebecq’s writing style. This thesis also proposes a ‘classical heritage’ for the realism of two of Houellebecq’s novels, Les Particules élémentaires and Plateforme, and argues that epic narration and tragic plot structure, both features of Balzacian realism, are the main formal devices of these two novels respectively. This thesis, then, looks at Houellebecq’s realism not from the point of view of an external ‘reality’ to which his novels refer, but rather in terms of a principle of reality which structures the action of the novels.
Experiences of psychological distress, uncertainty, and coping amongst people with cancer
Creators: name: Slater, Hayley
Publisher: name: Lancaster University
Year: 2020

description: The thesis entitled ‘Experiences of Psychological Distress, Uncertainty, and Coping Amongst People with Cancer’ explores the psychological experiences of individuals affected by cancer. A systematic literature review of the of the relationship between psychological distress and uncertainty amongst younger adults with cancer is presented in section one. Fifteen eligible studies were identified via database and hand searches. Risk of bias assessments were carried out. Findings demonstrated a highly significant relationship between uncertainty and psychological distress, with a number of studies indicating that uncertainty predicts psychological distress. Inconsistency in findings, however, suggests that other variables may influence this relationship. Risks of bias were identified across studies. A research study exploring patients’ experiences of coping longer-term with cancer of unknown primary (CUP) is presented in section two. Interviews were carried out with ten participants and data was analysed using interpretative phenomenological analysis. Three superordinate themes were identified: (1) ‘“Fuss and Bother”: The Upheaval of Everyday Life’, with subordinate themes of ‘Appointment threats’, and ‘Symptoms and side-effects’; (2) ‘“It’s the Unknowing”: The Enduring Uncertainty of CUP’ with subordinate themes of ‘“What the bloody hell’s that?!”’, ‘An uncertain future’, and ‘Hope’; and (3) ‘“Just Get on With It”: Managing and Moving Forwards’ with subordinate themes of ‘Maintaining normality’, ‘Acceptance’, and ‘Support’. Findings highlighted that the experiences of people living longer-term with CUP are comparable to those of other cancer patient populations, however, they also face a number of distinct challenges. A critical appraisal of the research paper is presented in section three. Within the critical appraisal, consideration is given to the epistemological and ontological assumptions made within the thesis, the position of the researcher and the importance of researcher reflexivity, and the research process. The ethics application and associated documentation are presented in section four.
Into the fold: a contemporary history of LGBT-police relations in Victoria
Creators: name: Russell, Emma Kate
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: In recent times, the interrelationship between policing and sexuality has been reworked in significant ways. No longer solely a site for the reproduction of queer deviancy, pathology and criminality, policing now serves as a method for the production of respectable and innocent sexual and gender identities that are seen as deserving of visibility, recognition and protection. Through an investigation of lesbian, gay, bisexual, and transgender (LGBT)-police relations in the Australian state of Victoria from 1994 until the present, this research documents the incorporation of limited formations of sexual and gender diversity into regimes of policing and punishment. I conceptualise this as a process of bringing LGBT rights ‘into the fold of the state’ (Agathangelou, Bassichis & Spira 2008: 122). This thesis forwards the claim that modes of inclusion are always connected to forms of exclusion. Moving away from the idea of inclusion as inherently positive and desirable, I critically interrogate some of the possible costs, compromises, risks and benefits associated with the incorporation of LGBT rights into criminal justice frameworks. This study provokes concerns over the renewed legitimation and justification for regimes of policing and punishment that are gained on the backs of claims to LGBT protection. Using a qualitative methodology, informed by critical discourse analysis and genealogical methods, I examine a variety of texts in the archive that are generated by mainstream and LGBT media, government agencies, LGBT organisations, activist campaigns and other individuals. I provide three case studies to illustrate some of the different ways in which sexual and gender non-conformity are policed: the Tasty nightclub raid (1994); the participation of the Chief Commissioner of Victoria Police in Pride March (2002); and hate crime sentencing reform (2009). In each case study I highlight dominant articulations of queerness used to garner popular support for anti-homophobic causes that, as I show, are imbricated in the politics of respectability, victimhood, consumption, and self-responsibility, whether resisting or affirming these categories (or sometimes both or neither). I investigate how police legitimacy may be enabled or constrained in their dealings with LGBT people by unpacking some of the techniques used to reproduce and fortify institutional legitimacy and create a positive police image within the LGBT community. I suggest that for police, their legitimacy has become increasingly bound up with appearing responsive to LGBT concerns.
Noncommutative Brownian motion
Creators: name: Santos, Willien O.
name: Almeida, Guilherme M. A.
name: Souza, Andre M. C.
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We investigate the classical Brownian motion of a particle in a two-dimensional noncommutative (NC) space. Using the standard NC algebra embodied by the sympletic Weyl-Moyal formalism we find that noncommutativity induces a non-vanishing correlation between both coordinates at different times. The effect stands out as a signature of spatial noncommutativity and thus could offer a way to experimentally detect the phenomena. We further discuss some limiting scenarios and the trade-off between the scale imposed by the NC structure and the parameters of the Brownian motion itself.
description: 9 pages
Supersaturated lipid-based drug delivery systems – exploring impact of lipid composition type and drug properties on supersaturability and physical stability
Creators: name: Ilie, Alexandra-Roxana
name: Griffin, Brendan T.
name: Kolakovic, Ruzica
name: Vertzoni, Maria
name: Kuentz, Martin
name: Holm, René
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objective: The objective of this study was to systematically investigate the impact of lipid composition on the ability to design supersaturated lipid-based drug delivery systems (sLBDDS) using three model drugs with different physico-chemical properties. Significance: This study expands the list of investigated sLBDDS by using alternative vehicle compositions relative to current literature. Methods and results: Drug supersaturation was thermally-induced based on previously reported methods and was successfully achieved for celecoxib and cinnarizine. For the novel drug, JNJ-2A, a lower supersaturation potential was observed for the tested LBDDS. For celecoxib and cinnarizine, crystalline precipitate was observed for some sLBDDS upon storage at 25 °C/65%RH, particularly for medium chain sLBDDS (celecoxib) and long chain sLBDDS (cinnarizine). The greater risk of precipitation observed for celecoxib and cinnarizine, particularly at higher apparent degree of supersaturation (aDS) may be related to their higher crystallization tendency as determined by differential scanning calorimetry. Conclusions: The potential for supersaturation in LBDDS, and the risk of precipitation, was found to be highly drug dependent. The apparent degree of supersaturation was considered a major factor impacting the ability to maintain drug supersaturation upon storage.
Towards a clinical test for infraspinatus pathology
Creators: name: Hughes, Phillip Charles
Publisher: name: La Trobe
Year: 2023

description: This thesis investigated the development of an accurate clinical test for infraspinatus pathology, a common source of shoulder pain. A systematic review of 25 studies found that most clinical tests for rotator cuff pathology were inaccurate. Moreover, all the clinical tests for infraspinatus pathology were inaccurate, except external rotation lag sign, in one study. For an infraspinatus clinical test to be accurate, the effect of the test on infraspinatus needs to be isolated from supraspinatus. A second systematic review suggested that differentiation was difficult, but if external rotation was resisted in flexion, in combination with the application of a longitudinal humeral force, infraspinatus might be isolated from supraspinatus. An electromyographic study, using surface and intramuscular electrodes, found that resisted shoulder external rotation from a position of flexion, might isolate infraspinatus from supraspinatus, on the basis of muscle activation. This study reported that both parts of infraspinatus are activated differently in resisted external rotation, with the oblique part being much more active than the transverse part. A cadaveric study using pressure sensitive transducers suggested that infraspinatus is subject to subacromial impingement on the posterior acromion in shoulder extension and external rotation. Supraspinatus is also subject to impingement on the anterior acromion in this position, so this movement would not serve as a clinical test specific to only infraspinatus. However, this movement will indicate subacromial impingement. The results from this thesis have suggested new directions for a clinical test for infraspinatus. This could involve resisted manual muscle testing or impingement of infraspinatus. While an accurate clinical test for infraspinatus pathology may or may not be possible in the long term, it is too early to declare it a goal out of reach. Further research effort is justified in the search for an accurate clinical test for infraspinatus pathology.

Submission note: A thesis written in partial fulfilment of the requirements for the degree of Doctor of Physiotherapy to the Department of Physiotherapy, Faculty of Health Sciences, La Trobe University, Bundoora.
Perception et observance des moyens de protection dans un contexte de pandémie de Covid-19
Creators: name: Baud, Olivier
name: Giard, Marine
name: Machut, Anaïs
name: Clauson, Hélène
name: Duplatre, Fernanda
name: Lacombe, Zéline
name: Savey, Anne
Publisher: name: Health & Co
Year: 2022
Subjects: Équipement de protection individuelle
Hygiène des mains
Perception
Observance

description: Objectif. L’appropriation des recommandations relatives aux équipements de protection individuelle (EPI) contre le SARS-CoV-2 par les professionnels de santé et leur adhésion à ces mesures dépendent de leur perception du risque. Cette étude évalue leur perception et leurs pratiques liées à l’utilisation des EPI et à l’hygiène des mains lors de la deuxième vague de l’épidémie. Méthode. Étude descriptive par auto-questionnaire en ligne réalisée en 2021. Les professionnels de santé des secteurs sanitaire, médico-social et de ville ont été interrogés sur leurs perceptions et pratiques. Une pondération a été attribuée à chaque thématique. Des taux de perception et d’observance ont été calculés. Résultats. 1 690 professionnels de santé des secteurs sanitaire, médico-social et de ville ont répondu. Hors risque d’aérosolisation, 71,6% pensent qu’un masque chirurgical est efficace ; avec risque d’aérosolisation, 97,4% pensent qu’un masque FFP2 est plus efficace qu’un masque chirurgical ; 91,9% pensent que les lunettes les protègent, mais 77,9% en portent ; 52,2% pensent qu’un tablier protège leur tenue ; 69,5% estiment maîtriser la transmission s’ils portent des gants dans les indications des précautions standard mais 61,4% les portent pour toute prise en charge d’une personne atteinte de Covid-19. Enfin, 92,9% jugent la friction hydro-alcoolique efficace. Les médianes de taux de perception (73%) et d’observance (78%) sont plus élevées chez les médecins et cadres que chez les aides-soignantes et agents de service hospitalier et selon le secteur d’activité. Conclusion. La perception de l’efficacité des EPI varie suivant les catégories professionnelles et les secteurs d’activité. Il semble nécessaire d’adapter le mode de communication à chaque métier.
Advanced phenomics- and genomics-based tools for molecular breeding of Ryegrass (Lolium spp.)
Creators: name: Pembleton, Luke William
Publisher: name: La Trobe
Year: 2023

description: Submission note: A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Applied Systems Biology, Faculty of Science, Technology and Engineering, La Trobe University, Bundoora.

Perennial ryegrass and Italian ryegrass are the most important temperate forage grasses for world pastoral agriculture. However, small levels of genetic gain, estimated at c. 0.25- 0.6% per annum, have been achieved by conventional ryegrass breeding programs. This genetic gain has been limited by a number of factors, such as an obligate outbreeding reproductive habit, a broad range of agronomically important traits but limited phenotypic assessment technologies, long breeding cycles, and inability to exploit heterosis. This thesis explores a number of innovative strategies and methodologies for enhancement of commercial ryegrass breeding. In the first instance, development of genomics and bioinformatics tools to enable the most effective establishment and maintenance of breeding nurseries, allowing capture and characterisation of useful genetic diversity. Secondly, development of high-throughput semi-automated low-cost phenotypic measurement protocols for forage quality traits, to enable the breeding of ryegrass with superior nutrient profiles matching the requirements of grazing ruminants, ultimately improving animal production, but also contributing to farm-system nutrient-use efficiency and reduced environmental impacts. Thirdly, conduct of a candidate gene-based association mapping study for such herbage quality traits, to initiate implementation of genomics-assisted breeding of ryegrass, while also providing a valuable insight into the most suitable pathways for application of genomic selection. Fourthly, presentation and exploration of a novel breeding design and methodology for commercial F1 hybrid ryegrass production, in order to enable breeders to capture, retain and exploit heterosis in their cultivars. Finally, development of a second-generation genotyping tool and associated bioinformatic procedures for identification and discrimination between ryegrass varieties, providing protection of breeder’s proprietary germplasm as well as quality assurance and quality control (QA/QC) within breeding programs. These advances offer improvements to commercial ryegrass breeding from the initial stages of breeding nursery establishment, through to phenotypic assessment, selection and breeding design, and finally to cultivar protection and QA/QC.
Compressibility regularizes the "$μ(I)$" rheology for granular flows
Creators: name: Heyman, J.
name: Delannay, R.
name: Tabuteau, H.
name: Valance, A.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: The $μ(I)$-rheology has been recently proposed as a potential candidate to model the flow of frictional grains in a dense inertial regime. However, this rheology was shown to be ill-posed in the mathematical sense for a large range of parameters, notably in the slow and fast flow limits \citep{Barker2015}. In this rapid communication, we extend the stability analysis to compressible flows. We show that compressibility regularizes mostly the equations, making them well-posed for all parameters, at the condition that sufficient dissipation is associated with volume changes. In addition to the usual Coulomb shear friction coefficient $μ$, we introduce a bulk friction coefficient $μ_b$, associated to volume changes and show that the equations are well-posed in two dimensions if $μ_b>2-2μ$ ($μ_b>3-7μ/2$ in three dimensions). Moreover, we show that the ill-posed domain defined in \citep{Barker2015} transforms into a domain where the equations are unstable but stay well-posed when compressibility is taken into account. These results suggest thus the importance of compressibility in dense granular flows.
(201091) Robert Strathern
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Deformation of an Amorphous Polymer during the Fused-Filament-Fabrication Method for Additive Manufacturing
Creators: name: McIlroy, Claire
name: Olmsted, Peter D.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: 3D printing is rapidly becoming an effective means of prototyping and creating custom consumer goods. The most common method for printing a polymer melt is fused filament fabrication (FFF), and involves extrusion of a thermoplastic material through a heated nozzle; the material is then built up layer-by-layer to fabricate a three-dimensional object. Under typical printing conditions the melt experiences high strain rates within the FFF nozzle, which are able to significantly stretch and orient the polymer molecules. In this paper, we model the deformation of an amorphous polymer melt during the extrusion process, where the fluid must make a 90$^\text{o}$ turn. The melt is described by a modified version of the Rolie-Poly model, which allows for flow-induced changes in the entanglement density. The complex polymer configurations in the cross-section of a printed layer are quantified and visualised. The deposition process involving the corner flow geometry dominates the deformation and significantly disentangles the melt.
Delivery of pDNA to lung epithelial cells using PLGA nanoparticles formulated with a cell-penetrating peptide: understanding the intracellular fate
Creators: name: dos Reis, Larissa Gomes
name: Lee, Wing-Hin
name: Svolos, Maree
name: Moir, Lyn M.
name: Jaber, Rima
name: Engel, Andrea
name: Windhab, Norbert
name: Young, Paul M.
name: Traini, Daniela
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: The combination of nanoparticles (NPs) and cell-penetrating peptide (CPP) represents a new opportunity to develop plasmid DNA (pDNA) delivery systems with desirable properties for lung delivery. In this study, poly(lactide-co-glycolide) (PLGA) NPs containing pDNA were formulated with and without CPP using a double-emulsion technique. NPs were characterized in regards of size, surface charge, release profile, pDNA encapsulation efficiency and pDNA integrity. Cellular uptake, intracellular trafficking, uptake mechanism and pDNA expression were assessed in both A549 and Beas-2B cells. Manufactured PLGA-NPs efficiently encapsulated pDNA with approximately 50% released in the first 24 h of incubation. Addition of CPP was essential to promote NP internalization in both cell lines, with 83.85 ± 1.2% and 96.76 ± 1.7% of Beas-2B and A549 cells, respectively, with internalized NP–DNA–CPP after 3 h of incubation. Internalization appears to occur mainly via clathrin-mediated endocytosis, with other pathways also being used by the different cell lines. An endosomal-escape mechanism seems to happen in both cell lines, and eGFP expression was observed in Beas-2B after 96 h of incubation. In summary, the NP–DNA–CPP delivery system efficiently encapsulated and protected pDNA structure and is being investigated as a promising tool for gene delivery to the lungs.
Middle-class Egyptian women negotiating marriage, family and work
Creators: name: Roque, Dahlia Tawhid
Publisher: name: Monash University
Year: 2019
Subjects: Uncategorized

description: Egyptian women have made impressive advances in educational attainment in recent decades, particularly at the tertiary level. Nevertheless, contrary to worldwide trends that illustrate a strong correlation between women’s educational attainment and labour market participation, in Egypt this rise has failed to coincide with an increase in women’s employment. Egypt has amongst the lowest female labour market participation rates in the world, with only 22.1 per cent of women aged 15-64 engaged in employment (CAPMAS, 2013). Furthermore, Egyptian women with university degrees have exceptionally low comparative employment rates at just 22.9 per cent (CAPMAS, 2011). This thesis investigates the reasons behind the remarkably low labour market participation rates of highly educated Egyptian women. The research presents an analysis of 38 in-depth interviews conducted with tertiary-educated, middle-class Egyptian women living in urban Cairo and Alexandria. The thesis contributes to the knowledge of marriage, wealth and resources amongst middle-class Egyptian women, and how these factors influence their employment status. It reveals the importance of pre-marital negotiations amongst middle class Egyptian families, and the key strategies that women employ in order to secure their economic wellbeing in their marital and domestic contexts. It illuminates the barriers that Egyptian women face in combining paid work and family care, and reveals how economic factors, such as opportunities for good jobs and decent pay impact on Egyptian women’s choices, with few factors facilitating workforce participation for the majority of middle-class women.
Positioning textile repair: viewing a culture of perfection through surface imperfections
Creators: name: Gale, Yolanta
name: Lilley, Debra
name: Wilson, Garrath
Publisher: name: Technische Universität Berlin
Year: 2021
Subjects: subject: 500 Naturwissenschaften und Mathematik
subject: 600 Technik, Technologie
subject: 300 Sozialwissenschaften
subject: repair
subject: perfection
subject: textiles
subject: imperfection
subject: culture

description: The practice of early disposal and trigger-happy purchasing practices are examples of a seemingly illogical response to no longer desired products. Current behaviour toward surface and product imperfections is representative of an endemic issue in the development of negative attitudes and culture towards imperfection, in order to address negative material concerns and habits associated with textile products, the connection between internally projected expectations of perfection need to be considered in conjunction with externally projected ideals. This paper examines the relationship between current adversities to textile imperfections and concepts of human imperfection. It positions the potential role that repair activity can have in addressing the current culture of perfection in textile surfaces.
PAUL J. CRUTZEN - Bibliography from PAUL JOZEF CRUTZEN. 3 December 1933 — 28 January 2021
Creators: name: Müller, Rolf
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Atmospheric Sciences
subject: FOS: Earth and related environmental sciences

description: Paul J. Crutzen was both a warm-hearted person and a brilliant scientist. His research interests were broad, encompassing topics of relevance in the mesosphere, the stratosphere and the troposphere. He made fundamental scientific contributions to a wide range of topics in the science of all these atmospheric regions. For example, he first described the NOx-driven ozone loss cycle in the stratosphere, he contributed key ideas on how to explain the ‘ozone hole’ and he made fundamental discoveries on the impact of biomass-burning on the atmosphere. Understanding and combating the origins of air pollution and climate change were driving motivations for his life's work. Further, he pioneered the concept that is known as ‘nuclear winter’, he initiated the resumption of discussion on geoengineering, and coined the term ‘Anthropocene’. In 1995, together with Mario J. Molina and F. Sherwood Rowland (ForMemRS 2004), Paul was awarded the Nobel Prize in chemistry for ground-breaking work ‘in atmospheric chemistry, particularly concerning the formation and decomposition of ozone’. With all this focus on science, he did not forget the importance of private life, regarding both his family and his colleagues and students. Finally, Paul's work had a profound influence not only on the scientific world, but also on different aspects of environmental politics throughout many countries. His works on the impact of human activities on the atmosphere and climate have been influential in the past and are influential today. They provide a beacon of knowledge for the next generations of scientists and environmental policymakers.
(201092) Francis Whitworth Russell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Dynamic-mechanical thermoanalysis test as a high-performance alternative for accelerated freeze-thaw stability testing: a case study of O/W emulsions
Creators: name: Cekic, Nebojsa D.
name: Savic, Sanela M.
name: Savic, Snezana D.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology

description: Objective: The main objective of this work was to evaluate the performance of recently developed dynamic-mechanical thermoanalysis (DMTA) test as a rapid rheological alternative to conventional freeze-thaw cycling for accelerated stability testing of oil-in-water (O/W) emulsions. Significance: The rational for this approach was reducing the time needed for product and process development and optimization, potentially through shortening the time needed for stability evaluation, in order to keep the pace with high formulating turnover imposed by increasing demands for placing products on the market, that is, to facilitate decision making in R&D and QC settings. Methods: Six model O/W emulsions were designed, rheologically characterized (continuous rotational and oscillatory tests), and subjected to stability evaluation through freeze-thaw test in stability chamber and DMTA tests using an air-bearing rheometer. Results: Investigated samples were characterized by favorized shear-thinning flow behavior with yield point. The elastic behavior dominated the viscous one in the LVE region of amplitude sweeps, as well as in the frequency sweeps of used frequency range. Statistical method comparison studies demonstrated that the results obtained by freeze-thaw test, routinely used for accelerated stability testing of emulsions, were in good accordance with those obtained with DMTA tests, whereas the time needed for stability assessment was significantly reduced (2–6 h versus 12 days). Conclusions: In summary, DMTA test proved to be an expeditious alternative for accelerated freeze-thaw stability testing of O/W emulsions, with great promise in new product development and optimization (R&D), as well as in determination of borderline product batches status (QC).
Task variability and the effectiveness of management control: the mediating effect of organisational learning
Creators: name: Yang Spencer, Xingdan Sarah
Publisher: name: La Trobe
Year: 2023

description: Submission note: A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the La Trobe Business School, Faculty of Business, Economics and Law, La Trobe University, Bundoora.

This thesis examines how organisational learning mediates the relationship between task variability and management control, and subsequently, the process through which the combined effect leads to effectiveness. Methodical learning and emergent learning from Miller’s (1996) learning dimensions are adopted to measure organisational learning. The conceptualisation of management control systems is derived from conventional organisational control theory, together with Simons’ Levers of Control framework. The effectiveness of management control systems is measured through job satisfaction and managerial performance. It is proposed in this study that the process through which task variability influences choice of management control is mediated by the type of organisational learning, and implied that effectiveness requires all of the elements in the process to be aligned. Hypotheses were tested using data collected from questionnaires distributed to managers in manufacturing organisations in Australia. The results reveal that organisational learning is a dynamic conscious process that can independently transmit the effect of task variability to effectiveness. During this process, management control mechanisms can also be used as learning mechanisms to implement subconscious learning and create dynamic tension. By doing so, organisations are able to build up capabilities to respond to the uncertainty whilst keeping track of financial performance. In regard to effectiveness, however, the outcomes are varied with the types of control implemented by the organisations. This thesis finds that selection and training procedures, a proxy for boundary input control, are the most proactive control mechanism in implementing emergent learning, subsequently leading to job satisfaction and improved managerial performance. The findings of this thesis add to our understanding of organisational learning and the principles of designing effective management control as a package. Additional contributions with respect to the management literature include developing a new organisational learning measure, combining conventional organisational control theory with Simons’ Levers of Control framework, and, from a methodological perspective, highlighting the difference between mediation effects and suppression effects and contributing to theory-building in this area.
Fighting Hislam : an investigation into Australian and North American Muslim women fighting sexism within their own communities from a pro-faith perspective
Creators: name: Carland, Susan Janet
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: This research investigates how Muslim women in Australia and North America fight sexism within their own communities from a pro-faith perspective. It examines the stories of the women who engaged in such work, their motivations, and their path to fighting sexism, the support and criticism they received from both Muslims and non-Muslims, and the role faith played in their work. Little previous research has been done in this field. The majority of the accounts of Muslim women portray them as passive victims of, or willing accomplices in perpetuating, sexism. That the negative attitudes towards feminism in many Muslim communities are based on histories of colonisation and secularism adds an extra layer of complexity to understanding the topic. To develop a nuanced understanding of how Australian and North American Muslim women fight sexism within their own communities from a pro-faith perspective, this study is enhanced by interviews with 23 Australian, US and Canadian female theologians, activists, writers and bloggers who shared their beliefs and experiences of struggling against patriarchy against their co-religionists. The women in this study show how they reconfigure internal tensions into knowledge production, grapple with the Double Bind, and embody a Third Way, all of which leads to them ultimately creating a new component of third wave feminism in the West. The research offers a crucial new understanding of Muslim women in minority contexts, the religious legacy they utilise, the forces that shape them, and forces they shape.
Families of elliptic curves in $\mathbb{P}^3$ and Bridgeland Stability
Creators: name: Gallardo, Patricio
name: Huerta, César Lozano
name: Schmidt, Benjamin
Publisher: name: arXiv
Year: 2016
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: We study wall crossings in Bridgeland stability for the Hilbert scheme of elliptic quartic curves in three dimensional projective space. We provide a geometric description of each of the moduli spaces we encounter, including when the second component of this Hilbert scheme appears. Along the way, we prove that the principal component of this Hilbert scheme is a double blow up with smooth centers of a Grassmannian, exhibiting a completely different proof of this known result by Avritzer and Vainsencher. This description allows us to compute the cone of effective divisors of this component.
description: 21 pages, 1 figure, small changes
Fermi Liquid to Luttinger Liquid Transition at the Edge of a Two-Dimensional Electron Gas
Creators: name: Grayson, M.
name: Hilke, M.
name: Pfeiffer, L. N.
name: Tsui, D. C.
name: West, K. W.
Publisher: name: The American Physical Society
Year: 2001
Subjects: subject: 530

description: Physical Review Letters
(201090) Thomas Henderson Orphoot
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Dynamic-mechanical thermoanalysis test as a high-performance alternative for accelerated freeze-thaw stability testing: A case study of O/W emulsions
Creators: name: Cekic, Nebojsa D.
name: Savic, Sanela M.
name: Savic, Snezana D.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology

description: Objective: The main objective of this work was to evaluate the performance of recently developed dynamic-mechanical thermoanalysis (DMTA) test as a rapid rheological alternative to conventional freeze-thaw cycling for accelerated stability testing of oil-in-water (O/W) emulsions. Significance: The rational for this approach was reducing the time needed for product and process development and optimization, potentially through shortening the time needed for stability evaluation, in order to keep the pace with high formulating turnover imposed by increasing demands for placing products on the market, that is, to facilitate decision making in R&D and QC settings. Methods: Six model O/W emulsions were designed, rheologically characterized (continuous rotational and oscillatory tests), and subjected to stability evaluation through freeze-thaw test in stability chamber and DMTA tests using an air-bearing rheometer. Results: Investigated samples were characterized by favorized shear-thinning flow behavior with yield point. The elastic behavior dominated the viscous one in the LVE region of amplitude sweeps, as well as in the frequency sweeps of used frequency range. Statistical method comparison studies demonstrated that the results obtained by freeze-thaw test, routinely used for accelerated stability testing of emulsions, were in good accordance with those obtained with DMTA tests, whereas the time needed for stability assessment was significantly reduced (2–6 h versus 12 days). Conclusions: In summary, DMTA test proved to be an expeditious alternative for accelerated freeze-thaw stability testing of O/W emulsions, with great promise in new product development and optimization (R&D), as well as in determination of borderline product batches status (QC).