Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis
Creators: name: Carlevaro-Fita, Joana
name: Hong, Chen
name: Mas-Ponte, David
name: Pedersen, Jakob Skou
name: Abascal, Federico
name: Amin, Samirkumar B.
name: Bader, Gary D.
name: Barenboim, Jonathan
name: Beroukhim, Rameen
name: Bertl, Johanna
name: Boroevich, Keith A.
name: Brunak, Søren
name: Campbell, Peter J.
name: Chakravarty, Dimple
name: Chan, Calvin Wing Yiu
name: Chen, Ken
name: Choi, Jung Kyoon
name: Deu-Pons, Jordi
name: Dhingra, Priyanka
name: Diamanti, Klev
name: Feuerbach, Lars
name: Fink, J. Lynn
name: Fonseca, Nuno A.
name: Frigola, Joan
name: Gambacorti-Passerini, Carlo
name: Garsed, Dale W.
name: Gerstein, Mark
name: Getz, Gad
name: Gonzalez-Perez, Abel
name: Guo, Qianyun
name: Gut, Ivo G.
name: Haan, David
name: Hamilton, Mark P.
name: Haradhvala, Nicholas J.
name: Harmanci, Arif O.
name: Helmy, Mohamed
name: Herrmann, Carl
name: Hess, Julian M.
name: Hobolth, Asger
name: Hodzic, Ermin
name: Hornshøj, Henrik
name: Isaev, Keren
name: Izarzugaza, Jose M. G.
name: Johnson, Rory
name: Johnson, Todd A.
name: Juul, Malene
name: Juul, Randi Istrup
name: Kahles, Andre
name: Kahraman, Abdullah
name: Kellis, Manolis
name: Khurana, Ekta
name: Kim, Jaegil
name: Kim, Jong K.
name: Kim, Youngwook
name: Komorowski, Jan
name: Korbel, Jan O.
name: Kumar, Sushant
name: Lanzós, Andrés
name: Larsson, Erik
name: Lawrence, Michael S.
name: Lee, Donghoon
name: Lehmann, Kjong-Van
name: Li, Shantao
name: Li, Xiaotong
name: Lin, Ziao
name: Liu, Eric Minwei
name: Lochovsky, Lucas
name: Lou, Shaoke
name: Madsen, Tobias
name: Marchal, Kathleen
name: Martincorena, Iñigo
name: Martinez-Fundichely, Alexander
name: Maruvka, Yosef E.
name: McGillivray, Patrick D.
name: Meyerson, William
name: Muiños, Ferran
name: Mularoni, Loris
name: Nakagawa, Hidewaki
name: Nielsen, Morten Muhlig
name: Paczkowska, Marta
name: Park, Keunchil
name: Park, Kiejung
name: Pich, Oriol
name: Pons, Tirso
name: Pulido-Tamayo, Sergio
name: Raphael, Benjamin J
name: Reimand, Jüri
name: Reyes-Salazar, Iker
name: Reyna, Matthew A.
name: Rheinbay, Esther
name: Rubin, Mark A.
name: Rubio-Perez, Carlota
name: Sabarinathan, Radhakrishnan
name: Sahinalp, S. Cenk
name: Saksena, Gordon
name: Salichos, Leonidas
name: Sander, Chris
name: Schumacher, Steven E.
name: Shackleton, Mark
name: Shapira, Ofer
name: Shen, Ciyue
name: Shrestha, Raunak
name: Shuai, Shimin
name: Sidiropoulos, Nikos
name: Sieverling, Lina
name: Sinnott-Armstrong, Nasa
name: Stein, Lincoln D.
name: Stuart, Joshua M.
name: Tamborero, David
name: Tiao, Grace
name: Tsunoda, Tatsuhiko
name: Umer, Husen M.
name: Uusküla-Reimand, Liis
name: Valencia, Alfonso
name: Vazquez, Miguel
name: Verbeke, Lieven P. C.
name: Wadelius, Claes
name: Wadi, Lina
name: Wang, Jiayin
name: Warrell, Jonathan
name: Waszak, Sebastian M.
name: Weischenfeldt, Joachim
name: Wheeler, David A.
name: Wu, Guanming
name: Yu, Jun
name: Zhang, Jing
name: Zhang, Xuanping
name: Zhang, Yan
name: Zhao, Zhongming
name: Zou, Lihua
name: Von Mering, Christian
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Article
/631/67/69
/631/208/212/748
article

description: Abstract: Long non-coding RNAs (lncRNAs) are a growing focus of cancer genomics studies, creating the need for a resource of lncRNAs with validated cancer roles. Furthermore, it remains debated whether mutated lncRNAs can drive tumorigenesis, and whether such functions could be conserved during evolution. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we introduce the Cancer LncRNA Census (CLC), a compilation of 122 GENCODE lncRNAs with causal roles in cancer phenotypes. In contrast to existing databases, CLC requires strong functional or genetic evidence. CLC genes are enriched amongst driver genes predicted from somatic mutations, and display characteristic genomic features. Strikingly, CLC genes are enriched for driver mutations from unbiased, genome-wide transposon-mutagenesis screens in mice. We identified 10 tumour-causing mutations in orthologues of 8 lncRNAs, including LINC-PINT and NEAT1, but not MALAT1. Thus CLC represents a dataset of high-confidence cancer lncRNAs. Mutagenesis maps are a novel means for identifying deeply-conserved roles of lncRNAs in tumorigenesis.