cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Use Dependent Attenuation of Rat HCN1-Mediated Ih in Intact HEK293 Cells
Creators: name: Barthel, Lennart
name: Reetz, Olivia
name: Strauss, Ulf
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background/Aims: Cationic currents (Ih) through the fast activating and relatively cAMP insensitive subtype of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, HCN1, are limited by cytosolic factors in mammalian cells. This cytosolic HCN1 break is boosted by changes in membrane voltage that are not characterized on a biophysical level, yet. Methods: We overexpressed rat (r)HCN1 in human embryonic kidney cells (HEK293) and recorded pharmacologically isolated Ih in cell-attached or whole-cell mode of the patch-clamp technique. Results: Recurring activation of rHCN1 reduced and slowed Ih in intact HEK293 cells (cell-attached mode). On the contrary, sustained disruption of the intracellular content (whole-cell mode) ceased activity dependence and partially enables voltage dependent hysteresis. The activity induced Ih attenuation in intact cells was independent of the main external cation, depended on the number of previous forced activations and was - at least in part - due to a shift in the voltage dependence of activation towards hyperpolarization as estimated by an adapted tail current analysis. Intracellular elevation of cAMP could not reverse the changes in Ih. Conclusion: Reduction of rHCN1 mediated Ih is use dependent and may involve the coupling of voltage sensor and pore.
Supplementary document for Doubly resonant second-harmonic generation of a vortex beam from a bound state in the continuum - 4727525.pdf
Creators: name: WANG, Jun
name: Clementi, Marco
name: Minkov, Momchil
name: Barone, Andrea
name: Carlin, Jean-Francois
name: Grandjean, Nicolas
name: Gerace, Dario
name: Fan, Shanhui
name: Galli, Matteo
name: Houdré, Romuald
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Uncategorized

description: This document contains 2 supplementary sections and 2 individual figures (S3 and S4) that have been mentioned in the manuscript.
Brain stimulation reward in the lateral preoptic area: An examination of its substrate and functional connectivity to the ventral tegmental area.
Creators: name: Bushnik Harris, Tamara L.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1993
Subjects: subject: Biology, Neuroscience.

description: In order to determine the nature of the hypothesized connection between the lateral preoptic and the ventral tegmental areas, two major experiments were conducted. The first major study consisted of an in-depth mapping of the substrate for self-stimulation in the lateral preoptic area using dorsoventrally moveable electrodes which permitted the testing and characterization of multiple stimulation sites in each subject. Self-stimulation was obtained throughout the lateral preoptic area and compartments 'a' and 'b' of the medial forebrain bundle; the pattern of positive sites was consistent with anatomical descriptions of the trajectory of the medial forebrain bundle. An examination of the period/current tradeoff functions generated at positive self-stimulation sites suggested that the substrate in the lateral preoptic area has a homogeneous distribution that is less dense than that found in the lateral hypothalamus. The next experiment investigated the existence of a direct anatomical connection between the lateral preoptic area and the ventral tegmental area reward neurons using the behavioural adaptation of the collision test. The collision test is a double pulse, two electrode technique based on the axonal conduction failure that occurs when two separate sites in the same axon bundle are electrically stimulated. In this study, nine rats with a total of forty-four pairs of sites were examined. In seven sites the double-pulse effectiveness curves were consistent with the characteristics of transynaptic collision. The unique shapes of collision curves predicted by the transynaptic collision model permit the direction of conduction to be inferred from the matching collision profiles; six of the seven curves were suggestive of a caudorostral direction of conduction, that is, ventral tegmental area to lateral preoptic area. These results do not support the hypothesis that the lateral preoptic area is the location of the cell bodies of origin for the descending reward pathway that courses between the lateral hypothalamus and ventral tegmental area. However, the absence of axonal collision effects or transynaptic collision profiles consistent with a rostrocaudal direction of conduction can not be interpreted to suggest that other patterns of connectivity between the reward neurons in the lateral preoptic and ventral tegmental areas do not exist. (Abstract shortened by UMI.)
title: Sanierungsmanagement für lokale und flächenhafte PFAS-Kontaminationen
title: Sanierungsmanagement für lokale und flächenhafte PFAS-Kontaminationen
titleType: AlternativeTitle
Creators: name: Held, Thomas
name: Reinhard, Michael
Publisher: name: Umweltbundesamt
Year: 2020
Subjects: subject: Vorläufersubstanz
subject: Punktquelle
subject: Flächenquelle
subject: Bodenverunreinigung
subject: PFC
subject: precursor
subject: Sanierungsmanagement
subject: PFAS
subject: Bodenkontamination
subject: Boden | Fläche

description: Die Stoffgruppe der ⁠PFAS⁠ gewinnt bei der Bearbeitung von Altlasten und schädlichen Bodenveränderungen zunehmend an Bedeutung. Die vorliegende Arbeitshilfe „Sanierungsmanagement für lokale und flächenhafte PFAS-Kontaminationen“ unterstützt vollzugstauglich die zuständigen Behörden bei der Vorauswahl, der Bewertung und der Entscheidung für ein geeignetes und verhältnismäßiges Sanierungsverfahren, zeigt relevante Rahmenbedingungen und flankierende Maßnahmen auf. Wegen der unterschiedlichen Stoffeigenschaften der PFAS sind auch die möglichen Sanierungsverfahren einzelstoffspezifisch zu bewerten. Es werden für die in Frage kommenden Sanierungsverfahren die Vor- und Nachteile, die technischen und genehmigungsrechtlichen Voraussetzungen sowie deren ⁠Nachhaltigkeit⁠ aufgezeigt.
Nickel-sodalite catalysts for hydrocracking of lloydminster atmospheric residuum.
Creators: name: Bergeron, Marie Colette Isabelle.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1993
Subjects: subject: Engineering, Chemical.

description: Colour degradation and heteroatom removal were studied in hydrocracking of Lloydminster atmospheric residue using conventional CoMo/Al$\sb2$O$\sb3$ catalysts containing a Ni-sodalite component. Nickel ion exchange and impregnation were performed on basic sodalite prepared in laboratory which was combined to an aqueous mixture of $\alpha$-alumina monohydrate, ammonium paramolybdate and cobalt nitrate to form the final catalysts. Each catalyst was evaluated in a high pressure continuous flow reaction system in which hydrogen and Lloydminster atmospheric bottoms were mixed and flowed upward through a fixed bed catalytic reactor. The reaction conditions were 17.3 MPa, 415$\sp\circ$C, and 0.59h$\sp{-1}$ or 1.07h$\sp{-1}$ LSV. Ni-SOD was found to increase the rate at which the maximum colour of the diesel fraction was developed. Sulphur content of the diesel fraction was related to colour formation and a mathematical expression was developed to express colour degradation. Total nitrogen content was found to have no direct effect on colour formation. The presence of Ni-SOD also improved hydrodemetallation (HDM), hydrodesulphurization (HDS) and microcarbon residue (MCR) removal with maximum conversion for a Ni-SOD content of 10%. HDN was reduced in the total liquid product, but improved in the diesel fraction as the content of Ni-SOD increased.
Living life on the edge: wide-field VLBI at 90 cm!
Creators: name: Lenc, Emil
name: Garrett, Mike
name: Wucknitz, Olaf
name: Anderson, James
name: Tingay, Steven
Publisher: name: Swinburne
Year: 2024

description: We report on a recent 90 cm wide-field VLBI survey of two 3.1 deg2 fields using the VLBA, Westerbork and Jodrell Bank telescopes. In-beam calibration was used to calibrate each field, the process was simplified by imaging the calibrators in DIFMAP and transferring the calibration solutions to AIPS using the newly developed DIFMAP task - cordump. We detected and imaged 13 out of the 141 sources originally detected by the low resolution (54′′) WENSS survey of the same two fields. The sources were detected at 7−12 sigma levels above the image noise, had total flux densities ranging between 85−1640 mJy and were between 16′−58′ from the phase centre of each field. This is the first systematic (and non-biased), deep, high resolution survey of the low frequency radio sky. These initial results suggest that new instruments such as LOFAR should detect many compact radio sources and that plans to extend these arrays to baselines of several thousand kilometres are warranted.
title: Causas de dolor pélvico agudo de origen ginecológico: hallazgos radiológicos
Creators: name: López Blasco, Ignacio
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Abdomen

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Identificar y describir los hallazgos radiológicos más característicos de la patología ginecológica más frecuente que cursa con dolor pélvico agudo en ecografía abdominal o transvaginal,
TC y RM. Reconocer los signos radiológicos que...
title: La cisternografía por Resonancia Magnética (RM) con Gadolinio Intratecal. Más allá de la detección de fístulas.
Creators: name: Feliu Rey, Eloisa
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Cerebrospinal fluid
subject: Fistula
subject: Puncture
subject: Contrast agent-other
subject: MR
subject: Head and neck

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Mostrar la técnica de la cisternografía por RM con administración de gadolinio (GD) intratecal así como otras utilidades además de la detección de fístulas,
basadas en nuestra propia...
Vegetation Phenology Driving Error Variation in Digital Aerial Photogrammetrically Derived Terrain Models
Creators: name: Goodbody, Tristan R.H.
name: Coops, Nicholas C.
name: Hermosilla, Txomin
name: Tompalski, Piotr
name: Pelletier, Gaetan
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Digital aerial photogrammetry (DAP) and unmanned aerial systems (UAS) have emerged as synergistic technologies capable of enhancing forest inventory information. A known limitation of DAP technology is its ability to derive terrain surfaces in areas with moderate to high vegetation coverage. In this study, we sought to investigate the influence of flight acquisition timing on the accuracy and coverage of digital terrain models (DTM) in a low cover forest area in New Brunswick, Canada. To do so, a multi-temporal UAS-acquired DAP data set was used. Acquired imagery was photogrammetrically processed to produce high quality DAP point clouds, from which DTMs were derived. Individual DTMs were evaluated for error using an airborne laser scanning (ALS)-derived DTM as a reference. Unobstructed road areas were used to validate DAP DTM error. Generalized additive mixed models (GAMM) were generated to assess the significance of acquisition timing on mean vegetation cover, DTM error, and proportional DAP coverage. GAMM models for mean vegetation cover and DTM error were found to be significantly influenced by acquisition date. A best available terrain pixel (BATP) compositing exercise was conducted to generate a best possible UAS DAP-derived DTM and outline the importance of flight acquisition timing. The BATP DTM yielded a mean error of −0.01 m. This study helps to show that the timing of DAP acquisitions can influence the accuracy and coverage of DTMs in low cover vegetation areas. These findings provide insight to improve future data set quality and provide a means for managers to cost-effectively derive high accuracy terrain models post-management activity.
The uncertainties in the 22Ne+ alpha-capture reaction rates and the production of the heavy magnesium isotopes in asymptotic giant branch stars of intermediate mass
Creators: name: Karakas, Amanda I.
name: Lugaro, Maria A.
name: Wiescher, Michael C.
name: Görres, Joachim
name: Ugalde, Claudio
Publisher: name: Swinburne
Year: 2024

description: Abstract not available.
title: Valor de la RM y de la FDG-PET-TC en el control y seguimiento de las lesiones tumorales de cabeza y cuello tratadas
Creators: name: Frascheri Verzelli, Laura
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Neoplasia
subject: Outcomes analysis
subject: MR
subject: PET-CT
subject: Head and neck

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
INTRODUCCIÓN Y OBJETIVOS Las lesiones tumorales de cabeza y cuello son una causa importante de morbimortalidad en todo el mundo,
siendo el carcinoma escamoso (SCC) el más frecuente. Estas lesiones tienen ciertas características que los...
title: Diagnostic value of plasma NGAL and intraoperative diuresis for AKI after major gynecological surgery in patients treated within an intraoperative goal- directed hemodynamic algorithm
title: A substudy of a randomized controlled trial
titleType: Subtitle
Creators: name: Hunsicker, Oliver
name: Feldheiser, Aarne
name: Weimann, Andreas
name: Liehre, David
name: Sehouli, Jalid
name: Wernecke, Klaus-Dieter
name: Spies, Claudia
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: acute kidney injury
subject: creatinine
subject: diuresis
subject: goal-directed therapy
subject: neutrophil gelatinase-associated lipocalin
subject: sensitivity and specificity
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Data on early markers for acute kidney injury (AKI) after noncardiovascular surgery are still limited. This study aimed to determine the diagnostic value of plasma neutrophil-gelatinase-associated lipocalin (pNGAL) and intraoperative diuresis for AKI in patients undergoing major abdominal surgery treated within a goal-directed hemodynamic algorithm. This study is a post-hoc analysis of a randomized controlled pilot trial comparing intravenous solutions within a hemodynamic goal-directed algorithm based on the esophageal Doppler in patients undergoing epithelial ovarian cancer surgery. The diagnostic value of plasma NGAL obtained at ICU admission and intraoperative diuresis was determined with respect to patients already meeting AKI criteria 6 hours after surgery (AKI6h) and to all patients meeting AKI criteria at least once during the postoperative course (AKItotal). AKI was diagnosed by the definition of the Kidney Disease Improving Global Outcome (KDIGO) group creatinine criteria and was screened up to postoperative day 3. Receiver operating characteristic curves including a gray zone approach were performed. A total of 48 patients were analyzed. None of the patients had increased creatinine levels before surgery and 14 patients (29.2%) developed AKI after surgery. Plasma NGAL was predictive for AKI6h (AUCAKI6h 0.832 (95% confidence interval [CI], 0.629–0.976), P = .001) and AKItotal (AUCAKItotal 0.710 (CI 0.511–0.878), P = .023). The gray zones of pNGAL calculated for AKI6h and AKItotal were 210 to 245 and 207 to 274 ng mL−1, respectively. The lower cutoffs of the gray zone at 207 and 210 ng mL−1 had a negative predictive value (NPV) (i.e., no AKI during the postoperative course) of 96.8% (CI 90–100) and 87.1% (CI 78–97), respectively. Intraoperative diuresis was also predictive for AKI6h (AUCAKI6h 0.742 (CI 0.581–0.871), P = .019) with a gray zone of 0.5 to 2.0 mL kg−1 h−1. At the lower cutoff of the gray zone at 0.5 mL kg−1 h−1, corresponding to the oliguric threshold, the NPV was 84.2% (78–92). This study indicates that pNGAL can be used as an early marker to rule out AKI occurring within 3 days after major abdominal surgery. Intraoperative diuresis can be used to rule out AKI occurring up to 6 hours after surgery.
Deriving structure‐performance relations of chemically modified chitosan binders for sustainable high‐voltage LiNi0.5Mn1.5O4 cathodes
Creators: name: Kuenzel, Matthias
name: Porhiel, Regis
name: Bresser, Dominic
name: Asenbauer, Jakob
name: Axmann, Peter
name: Wohlfahrt‐Mehrens, Margret
name: Passerini, Stefano
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: aqueous electrode processing
subject: binder crosslinking
subject: high-voltage cathode
subject: DDC 540 / Chemistry & allied sciences
subject: Chitosan
subject: Lithium ion batteries
subject: Lithium-Ionen-Akkumulator

description: The secret ingredient? Acid or gum: Bio-derived chitosan serves as environmentally benign binding agent for high-voltage LiNi0.5Mn1.5O4 positive electrodes. The electrochemical performance of such electrodes depends strongly on the chain length and degree of deacetylation of the water-processable biopolymer and can be improved significantly through chemical modification by means of crosslinking with citric acid or the incorporation of a second water-soluble polymer like guar gum. The implementation of aqueous electrode processing for lithium-ion positive electrodes is key towards the realization of environmentally benign and cheap battery production. One of the water-soluble binders that has attracted most attention is chitosan, the second-most abundant natural biopolymer. Herein, the use of chitosan for high-voltage, cobalt-free LiNi0.5Mn1.5O4 cathodes is reported for the first time. A detailed comparison of three different grades of chitosan with varying chain length and degrees of deacetylation (DD) is provided to explore the impact of these properties on the electrochemical performance. In fact, bio-derived chitosan with a relatively lower DD outperforms synthetic chitosan-especially after crosslinking with citric acid-yielding about 10 % higher capacities. Higher molecular weight appears additionally advantageous for the cycling stability. Finally, guar gum is employed as slurry thickener, co-crosslinking with chitosan. This allows for achieving 50 % higher mass loadings than for chitosan only and stable capacities above 130 and 120 mAh g−1 at C/3 and 1 C, respectively.
title: Actualización radiológica en la patología de las glándulas salivares
Creators: name: González Caballero, María José
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Salivary glands

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
La patología de las glándulas salivales es frecuente en el servicio de ORL de nuestro Hospital,
siendo el examen inicial estos pacientes la ecografía. 1) Describir la anatomía radiológica normal de las glándulas salivales mayores...
Numerical study of the factors affecting the cycling of iron, sulfur and phosphorus in lake sediments
Creators: name: Tsandev, Iana
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Biology, Oceanography.
subject: Physics, General.

description: In recent years, reaction transport models have gained importance in the study of diagenesis, which describes the chemical, biological and physical processes that take place in sediments. This project reports on factors influencing chemical profiles in lake sediments through an exploration of a generic reaction transport model which includes representations of the major reactions involved in the cycling of iron, sulfur and phosphorus. We have performed a global sensitivity analysis examining the steady state effects of physical, kinetic and thermodynamic factors on the magnitude, shape and burial concentrations of chemical profiles of iron, sulfur and phosphorus-bearing species. The environmental conditions were varied within a broad range typical of lake sediments. The exploration demonstrates the importance of the nature of boundary conditions (i.e. characteristics of the water column) and their coupling to the water column dynamics. The study additionally points to some chemical mechanisms such as precipitation of vivianite and scavenging of vivianite by sulfide having a dominant influence on the depth profiles of chemical species. Investigation also shows the importance of physical transport processes such as bioturbation near the sediment water interface and sedimentation velocity. Additionally, the distribution of reaction rates with depth and their role in shaping the profiles of chemical concentrations under typical environmental conditions were investigated.
Marina filiciformis, comb. nov.
Creators: name: Urrego, Paola Piñeros
name: Suárez-Barón, Harold
name: Pabón-Mora, Natalia
name: González, Favio
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Fabales
Fabaceae
Marina
Marina filiciformis

description: Marina filiciformis (B.L. Rob. & Greenm.) Piñeros-U. & F. González, comb. nov.
Basionym: Dalea filiciformis B.L.Rob. & Greenm., Proc. Amer. Acad. 29: 382. 1894 = Parosela filiciformis (B.L.Rob. & Greenm.) Rose, Contrib. U.S. Nat. Herb. 8: 303. 1905.
The transfer of Dalea filiciformis to the genus Marina (suggested but not formally validated by McMahon and Hufford, 2004) is consistent with the presence of pedicellate flowers and harp-shaped pods with two distinct crescents of blister glands, two traits that are distinctive of Marina (Barneby 1977). However, other morphological traits commonly found in Dalea and likely present in M. filiciformis, such as leaflets with minute blister glands, two collateral ovules per ovary, spiral trichomes on the calyx, and a preliminary chromosome counting of 8 (versus leaflets with lineariform glands, one ovule per ovary, calyx trichomes not spirally twisted, and x = 10 in most Marina spp.) remain to be studied in detail.
(Continúa)
(Continúa)
Finally, the phylogenetic relationships of the Colombian species of Dalea (D. coerulea, D. cuatrecasasii, D. foliolosa and D. wilsonii) remains uncertain. The analysis based on ITS does not recover them as monophyletic (Suppl. Fig. 1), as D. coerulea results closely related to the Peruvian D. myriadenia and D. weberbaueri, whereas D. cuatrecasasii clusters with D. bicolor and D. versicolor, from southern United States and Mexico. Conversely, in the analyses based on matK/trnK (Suppl. Fig. 3) and the combined ITS + matK/trnK (Fig. 2), they come out as monophyletic, clustered either with D. pulchra, from southern United States, or with D. melantha, from southern North America and Mexico, respectively. More data are required to arrive at a better understanding of the phylogenetic relationship between the North- and Mesoamerican species of Dalea and their South American congeners.
description: Published as part of Urrego, Paola Piñeros, Suárez-Barón, Harold, Pabón-Mora, Natalia & González, Favio, 2023, Reinstatement of the genus Psorodendron and related systematic novelties as revealed from phylogenetic analyses of the tribe Amorpheae (Leguminosae, Papilionoideae), pp. 49-65 in Caldasia 45 (1) on pages 58-61, DOI: 10.15446/caldasia.v45n1.96498, http://zenodo.org/record/15265087
On the reliability of sense perceptions in Epicurean epistemology
Creators: name: Schneider, Zeev
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Philosophy.

description: In this thesis I advance an interpretation of the statement, famously attributed to Epicurus by several ancient sources, 'all perceptions ( aistheseis or phantosia) are true (alethes).' The statement earned Epicurus and his followers the scorn and ridicule of prominent non-Epicurean figures, including Cicero and Plutarch, and has remained the subject of scholarly controversy. The interpretation I advance in this thesis is oriented around the foundational role of perceptions in Epicurean epistemology. Though they are themselves irrational (alogos), perceptions are both the basis of all reasoning and criteria of truth in Epicurus' system. To show how all perceptions are true in this role, I analyse the causal mechanism of perception and show that the content of each perception is basic and irreducible: no perception can contradict another and all are equally reliable as evidence. Thus, on my reading, the truth of all perceptions refers to their reliability in Epicurus' method.
Design of agent-oriented pattern templates
Creators: name: Oluyomi, Ayodele
name: Karunasekera, Shanika
name: Sterling, Leon
Publisher: name: Swinburne
Year: 2024

description: Software patterns have potential to enhance the comprehension, application and communication of agent oriented software concepts. To realize this potential, agent oriented patterns should be appropriately described with the aid of good pattern templates. However, many of the existing descriptions of agent patterns lack certain features that are critical to the description of agent patterns. In this paper, we present a design for agent oriented pattern templates. We present two templates built according to our design that we believe improve on the description of agent patterns. The InteRRaP agent architectural pattern and Contract Net agent interaction pattern are presented using these templates.
INF1 is a novel microtubule and actin cytoskeleton cross-linking protein
Creators: name: Thurston, Susan Frances
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Biology, Molecular.

description: Formin proteins, characterized by two conserved formin homology (FH) domains, play an important role in cytoskeletal regulation and dynamics. The FH domains are most commonly implicated with the polymerization of F-actin and more recently with the stabilization of microtubules. Inverted formin 1 (INF1) is an atypical formin that has its FH1 and FH2 domains in its N-terminus. The C-terminus of INF1 contains five conserved regions unlike any other sequence found in the database. In this study, we demonstrate that INF1 discreetly associates with microtubules via a unique bipartite microtubule-binding domain (MTBD) in the C-terminus. Additionally, similar to the diaphanous related formin mDia, INF1 induces microtubule stabilization and acetylation. Expression of the MTBD alone, and not the FH2 domain, is sufficient to induce microtubule stabilization. However, in the absence of the MTBD, the N-terminus induces microtubule stabilization dependent on the presence of both the FH1 and the FH2 domains. In addition, knockdown of INF1 protein in NIH 3T3 fibroblasts results in a dramatic loss of acetylated microtubules suggesting INF1 is required for MT acetylation in these cells. Furthermore, we show that INF1 is not regulated by auto-inhibition, but is constitutively active both in vivo and in vitro. Our overexpression results suggest the INF1 C-terminus contains a putative regulatory domain targeted by an unknown inhibitory factor. Finally, we show that INF1 is capable of bundling both microtubules and F-actin simultaneously, implying that INF1 is a cytoskeletal cross-linking protein that could play an important role in cell polarity, cell migration and other cytoskeletal dependent processes.
Supplementary document for Additive manufacturing of highly reconfigurable plasmonic circuits for terahertz communications - 4728005.pdf
Creators: name: Cao, Yang
name: nallappan, kathirvel
name: Guerboukha, Hichem
name: XU, GUOFU
name: Skorobogatiy, Maksim
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: The Supplementary Material
title: Nuestra experiencia en lesiones quísticas cervicales de etiología congénita
Creators: name: Hernandez Caler, Rocio
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Infection
subject: Congenital
subject: Acute
subject: Surgery
subject: Biopsy
subject: Ultrasound
subject: CT-High Resolution
subject: Head and neck
subject: Anatomy

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Describirlas características clínicas y radiológicas más frecuentes de las lesiones congénitas quísticas del cuello. Valorar la utilidad de las diferentes pruebas de imagen (ecografía,
TC y RM) en el diagnóstico de las lesiones quísticas...
title: Interés de la ecografía intraoperatoria en la búsqueda de metástasis hepáticas de carcinoma colorrectal durante la realización de metastasectomía.
Creators: name: Salmerón Ruiz, Ángela
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Neoplasia
subject: Diagnostic procedure
subject: Intraoperative
subject: Observer performance
subject: CT
subject: PET-CT
subject: Echocardiography
subject: Oncology
subject: Abdomen
subject: Liver

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
- Establecer la concordancia de la ecografía intraoperatoria con el diágnostico preoperatorio (PET,
ecografía y TC) y el estudio anatomopatológico. - Analizar los datos que ayudan al cirujano en la planificación quirúrgica en cuanto a número...
title: Utilidad de la Resonancia Magnética de Mama para el estudio de la Secreción por el Pezón
Creators: name: Madrid Vallenilla, Andrés Enrique
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Breast
subject: Interventional non-vascular
subject: Mammography
subject: Digital radiography
subject: MR
subject: Technical aspects
subject: Galactography
subject: Comparative studies
subject: Neoplasia
subject: Hyperplasia / Hypertrophy

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
Objetivos: Actualmente se considera a la galactografía,
la técnica por imagen de elección para el estudio de pacientes con telorrea-telorragia,
ya que en un porcentaje significativo de éstas pacientes la mamografía y la ecografía no muestran...
Genome Rearrangements: Structural Inference and Functional Consequences
Creators: name: Munoz, Adriana
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Biology, Bioinformatics.
subject: Computer Science.

description: As genomes evolve over hundreds of millions years, the chromosomes become rearranged, with segments of some chromosomes inverted, while other chromosomes reciprocally exchange chunks from their ends. These rearrangements lead to the scrambling of the elements of one genome with respect to another descended from a common ancestor. Multidisciplinary work undertakes to mathematically model these processes and to develop statistical analyses and mathematical algorithms to understand the scrambling in the chromosomes of two or more related genomes. A major focus is the reconstruction of the gene order of the ancestral genomes. There has been a trend in increasing the phylogenetic scope of genome sequencing without finishing the sequence for each genome. With less interest in completing the sequence, there is an increasing number of genomes being published in scaffold or even contig form. Rearrangement algorithms, including gene order-based phylogenetic tools, require whole genome data on gene order or syntenic block order. Then, for gene order-based comparisons or phylogeny, how can we use rearrangement algorithms to handle genomes available in contig or scaffold form only? For contig data, we develop a model for the behaviour of the genomic distance as a function of evolutionary time, and discuss how to invert this function in order to infer elapsed time. We show how to correct for the effect of chromosomal fragmentation in sets of contigs. We apply our methods to data originating mostly in the 12-genome Drosophila project [15]. We compare ten Drosophila genomes with two other dipteran genomes and two outgroup insect genomes. For scaffolds, our method involves optimally filling in genes missing in the scaffolds, and using the augmented scaffolds directly in the rearrangement algorithms as if they were chromosomes, while making a number of corrections, e.g., we correct for the number of extra fusion/fission operations required to make scaffolds comparable to full assemblies. We model the relationship between scaffold density and genomic distance, and estimate the parameters of this model while comparing the angiosperms genomes Ricinus communis and Vitis vinifera. A separate question arises of what the biological consequences of breakpoint creation are, rather than just their structural aspects. The question I will ask is whether proximity to the site of a breakpoint event changes the activity of a gene. I propose to investigate this by comparing the distribution of distances to the nearest breakpoint of genes that change expression in human versus the distribution of genes that do not change expression in human, compared to other primate species (e.g. macaque or chimpanzee). Keywords: chromosome rearrangement, comparative genomics, phylogenomics, phylogenetic tree, inversion, reciprocal translocation, transposition, DCJ, breakpoint, gene expression.
Alternative splicing regulation of the epithelial sodium channel (ENaC) in Dahl rats
Creators: name: Shehata, Marlene Fouad Amin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Biology, Molecular.

description: The epithelial sodium channel (ENaC) is critical in controlling the rate of renal sodium reabsorption and maintaining long term blood pressure control. ENaC activity is twice as high in kidneys of high salt-fed Dahl salt-sensitive (S) rats versus a sister salt-resistant strain (Dahl R), which might explain the increased blood pressure in high salt-fed Dahl S rats versus R rats. ENaC blockade in the brain by benzamil rescued Dahl S rats from salt-induced hypertension. The aims of the present study were: (i) To test whether Dahl S rats harbor genetic polymorphisms in the ENaC alpha, beta, and/or gamma genes that might contribute to their enhanced ENaC activity; (ii) To investigate whether alpha ENaC in Dahl rats' kidney is associated with alternatively spliced forms, and their corresponding mRNA levels, should they exist, in Dahl S versus R rats on normal and high salt diet; (iii) To examine the putative biological function of alpha ENaC alternatively spliced forms when co-expressed with alpha ENaC-wt. The first comprehensive sequence analysis of ENaC genes did not reveal any differences between Dahl S and R rats that were isogenic in the entire coding regions, exon-intron junctions, 3' and 5' flanking regions of ENaC alpha, beta, and gamma genes. Two coding (a and b) and two non coding (c and d) alpha ENaC alternatively spliced forms were identified whose mRNA levels were elevated in Dahl R versus S rats. Among the four alpha ENaC transcripts, the salt-sensitive alpha ENaC-b was highly abundant exceeding alpha ENaC-wt abundance by ∼32 fold. The translated alpha ENaC-b protein sequestered alpha ENaC-wt and reduced alpha ENaC-wt expression in a dose-dependent manner. Increased ENaC activity in Dahl S versus R rats might be attributed to the lower abundance of alpha ENaC-b, a dominant negative expression regulator of alpha ENaC.
“Where does the high road lead?” : Potential implications of cannabis legalization for pediatric injuries in Canada
Creators: name: Karbakhsh, Mojgan
name: Smith, Jennifer
name: Pike, Ian, 1958-
Publisher: name: Springer
Year: 2021

description: The purpose of this commentary is to discuss how legalization of non-medical marijuana (LNMM) in Canada can potentially influence child and adolescent unintentional injuries based on evidence from states (American) and jurisdictions that have already legalized cannabis for recreational purposes. Although the evidence is still not conclusive, LNMM can bring about higher exposure, lower perceived harms, and higher prevalence of cannabis use by minors through role modeling and normalization of behaviour within the household and the community, and higher rates of driving under the influence of cannabis, which can contribute to a higher burden of road traffic injuries. Experience of American states with LNMM shows higher rates of emergency visits for pediatric poisoning due to unintentional ingestion of cannabis-containing foods and severe burns due to explosions during the course of home-based cannabis extraction. While the justification for legalization has created a strict legal framework for improved control of cannabis in Canada, the implications for health and safety of children and adolescents necessitate further study, communication with policy-makers and public health practitioners, and evidence-based education of parents, caregivers, and youth.
title: Patología del pericardio: hallazgos en TCMD y RM
Creators: name: Olmedilla Arregui, Pilar
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: CT
subject: MR
subject: Thorax
subject: Cardiac

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
1)Describir la anatomía normal del pericardio en las imágenes de TCMD y RM. 2)Revisar el espectro de hallazgos de los distintos procesos patológicos,
congénitos y adquiridos,
que afectan al pericardio. 3)Definir la utilidad de ambas técnicas de...
The Most Ancient Spiral Galaxy: A 2.6-Gyr-old Disk with a Tranquil Velocity Field
Creators: name: Yuan, Tiantian
name: Richard, Johan
name: Gupta, Anshu
name: Federrath, Christoph
name: Sharma, Soniya
name: Groves, Brent A.
name: Kewley, Lisa J.
name: Cen, Renyue
name: Birnboim, Yuval
name: Fisher, Deanne
Publisher: name: Swinburne
Year: 2024

description: We report an integral-field spectroscopic (IFS) observation of a gravitationally lensed spiral galaxy A1689B11 at redshift z = 2.54. It is the most ancient spiral galaxy discovered to date and the second kinematically confirmed spiral at z greater than or similar to 2. Thanks to gravitational lensing, this is also by far the deepest IFS observation with the highest spatial resolution (similar to 400 pc) on a spiral galaxy at a cosmic time when the Hubble sequence is about to emerge. After correcting for a lensing magnification of 7.2 +/- 0.8, this primitive spiral disk has an intrinsic star formation rate of 22 +/- 2 M-circle dot yr(-1), a stellar mass of 10(9.8 +/- 0.3) M-circle dot, and a half-light radius of r(1/2) = 2.6 +/- 0.7 kpc, typical of a main-sequence star-forming galaxy at z similar to 2. However, the Ha kinematics show a surprisingly tranquil velocity field with an ordered rotation (V-c = 200 +/- 12 km s(-1)) and uniformly small velocity dispersions (V-sigma,V-mean = 23 +/- 4 km s(-1) and V-sigma,V-outer-disk = 15 +/- 2 km s(-1)). The low gas velocity dispersion is similar to local spiral galaxies and is consistent with the classic density wave theory where spiral arms form in dynamically cold and thin disks. We speculate that A1689B11 belongs to a population of rare spiral galaxies at z greater than or similar to 2 that mark the formation epoch of thin disks. Future observations with the James Webb Space Telescope will greatly increase the sample of these rare galaxies and unveil the earliest onset of spiral arms.
The neural foundations of an auditory-visual illusion: spatial factors and application to childhood development
Creators: name: Innes-Brown, Hamish
Publisher: name: Swinburne
Year: 2024

description: Most animals, including humans, possess multiple sense organs through which information about the environment is gleaned. The brain’s ability to integrate the information gathered from multiple sense modalities is fundamental to success in the environment. However, until fairly recently, the processing of sensory information in the brain was assumed to follow separate parallel streams, being progressively elaborated in these separate streams before being finally united in high level association cortices, such as those in the frontal or parietal lobes. As more sophisticated theories and analysis techniques have emerged, this view has given way to a new understanding that information is also transferred between sensory pathways at very early stages – at the level of the primary sensory cortices and possibly below. The three experiments presented in this thesis used the flash-beep illusion (Shams et al., 2000) as an index of multi-sensory processes in the brain – firstly to show that the illusion was robust to significant spatial separation of the auditory and visual parts of the stimulus, and secondly to show that congruent multi-modal stimuli initiated a sequence of long-lasting effects on subsequent uni-sensory processing that were localised to the parietal and occipital lobes. Lastly, it was shown that a group of children from 8-14 years of age reported significantly more illusions than adults, adding further weight to the growing body of evidence suggesting that many multi-sensory processes are slow to develop. Overall, the experiments reported in this thesis highlight the involvement of high-level cortical association areas as well as direct cortico-cortical connections between primary auditory and visual areas in the generation of the flash-beep illusion. It is proposed that both are required in order to generate the perception of an illusory flash: the multi-modal flash/beep stimulus initiates a sequence of activity in the primary sensory areas which subsequently leads to feedback from parietal areas, thus priming visual cortex. Direct, spatially insensitive connections from primary auditory to visual areas subserving the visual periphery may allow auditory activity generated by the second beep to trigger a visual percept. The results increase our understanding that multi-sensory processes are generally the result of complex interactions between sub-cortical nuclei and primary sensory areas, guided by top-down control from high-level association regions which are slow to develop during childhood.
Learning organization: How does the CCHSA accreditation process help health care organizations to develop their learning processes?
Creators: name: Weber, Sophia Aurora D
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Health Sciences, Health Care Management.

description: Objective. To demonstrate that participation in the CCHSA accreditation process helps HCOs to be more reactive to change, improving quality and safety, and that accreditation also helps health care organizations to develop their organizational learning processes. The hospital's culture is of a hierarchical nature (x¯ = 36.92), but with the help of organizational initiatives, strong leadership, and accreditation, it is evolving towards a group culture. The hospital has a high commitment towards information and analysis, however, employees do not always perceive themselves as receiving adequate training and education for quality improvement. Accreditation has helped the hospital through its merger. It has affected the hospital at an individual, group, organizational, and external partnerships level. The self-assessment phase was highly effective in encouraging cohesion and collaboration, the emergence of a multidisciplinary approach to care, community involvement, and the development of organizational learning. The first post-merger accreditation's report encouraged the development of an organization wide quality framework which focuses on quality of care, efficiency, and patient safety. Most key values and initiatives are in place for the hospital to be a Learning Organization. A shift in organizational culture towards a group and developmental culture, as well as a stronger commitment towards QI education and training, are still necessary. (Abstract shortened by UMI.)
Supplementary document for Beyond dipole excitation: the performance of quadrupole-based Huygens’ metasurface - 4728864.pdf
Creators: name: Liu, Chang
name: Ye, Han
name: Wang, Yu
name: Sun, Yunhang
name: Liu, Yumin
name: Yu, Zhongyuan
name: Yu, Li
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental results
title: Anomalías en el Desarrollo Embriológico de la Vena Cava y Tributarias.
Creators: name: Tienda Flores, Maria Jose
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Veins / Vena cava

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
El uso de las técnicas de imagen,
principalmente TC y RM,
han puesto de manifiesto las múltiples anomalías congénitas de la vena cava,
principalmente en pacientes asintomáticos,
encontradas como hallazgo incidental en estudios por otros...
Valeurs sous-jacentes à la polarité domination-soumission dans le couple et leur évolution : étude clinique de cas.
Creators: name: Garilus, Guillaume.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Psychology, Clinical.

description: Partant des theories de Hoskins ainsi que des Hone et Mercure, nous avons voulu dans cette etude, a l'aide de l'etude clinique de cas d'un couple, verifier: (a) si les valeurs des partenaires sont a la base de la polarite D-S/A dans leur relation et quelles sont ces valeurs; (b) si la clarification de ces valeurs par les conjoints et l'evolution de celles-ci peuvent favoriser entre eux une dynamique relationnelle plus fonctionnelle. En consequence, parmi cinq couples en therapie et ayant passe le test Dominance-Accommodation Scale de Hoskins (1986), nous avons selectionne un dont le score accusait dans leur relation une forte predominance de la dynamique D-S/A. Ce couple fut suivi en therapie par une therapeute du Centre de counseling de l'Universite saint Paul et a participe a 16 entrevues cliniques etalees sur 7 mois. Trois semaines apres ces entrevues, les conjoints passerent a nouveau le test Dominance-Accommodation et nous donnerent une entrevue de recherche sur leurs valeurs et la dynamique D-S/A dans leur relation. (Abstract shortened by UMI.)
Quantitative assessment of the asphericity of pretherapeutic FDG uptake as an independent predictor of outcome in NSCLC
Creators: name: Apostolova, Ivayla
name: Rogasch, Julian
name: Buchert, Ralph
name: Wertzel, Heinz
name: Achenbach, H. Jost
name: Schreiber, Jens
name: Riedel, Sandra
name: Furth, Christian
name: Lougovski, Alexandr
name: Schramm, Georg
name: Hofheinz, Frank
name: Amthauer, Holger
name: Steffen, Ingo G.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background The aim of the present study was to evaluate the predictive value of a novel quantitative measure for the spatial heterogeneity of FDG uptake, the asphericity (ASP) in patients with non-small cell lung cancer (NSCLC). Methods FDG-PET/CT had been performed in 60 patients (15 women, 45 men; median age, 65.5 years) with newly diagnosed NSCLC prior to therapy. The FDG-PET image of the primary tumor was segmented using the ROVER 3D segmentation tool based on thresholding at the volume-reproducing intensity threshold after subtraction of local background. ASP was defined as the relative deviation of the tumor’s shape from a sphere. Univariate and multivariate Cox regression as well as Kaplan-Meier (KM) analysis and log-rank test with respect to overall (OAS) and progression-free survival (PFS) were performed for clinical variables, SUVmax/mean, metabolically active tumor volume (MTV), total lesion glycolysis (TLG), ASP and “solidity”, another measure of shape irregularity. Results ASP, solidity and “primary surgical treatment” were significant independent predictors of PFS in multivariate Cox regression with binarized parameters (HR, 3.66; p