cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A role for adenosine monophosphate-activated protein kinase (AMPK) in steroid hormone signaling and uterine receptivity
Creators: name: GRIFFITHS, RICHARD MELTON
Publisher: name: Washington State University
Year: 2019
Subjects: Infertility, Female--Treatment
Protein kinases--Regulation

description: Approximately 6% of reproductive age women in the United States are infertile. Many such women seek Assisted Reproductive Technologies (ART) to overcome limitations to their reproductive capacity. A large and increasing percentage of women who require ART to become pregnant in first world countries are obese. Interestingly, the nutrient sensing signaling molecule adenosine monophosphate-activated protein kinase (AMPK) is down-regulated both in expression and enzymatic activity in obese women. Our lab recently established that when AMPK is not active in the female reproductive tract the result is subfertility that rapidly progresses to infertility. Additional consequences include accumulation of fibrotic tissue in the endometrial compartment that increases with each parity and endometrial inflammation, both indicative of endometritis. One possible cause of the infertility phenotype in these mutant mice is faulty steroid hormone signaling during the establishment of pregnancy. The purpose of the studies described herein are to test the hypothesis that AMPK functions to mediate some of the actions of steroid hormones within the female reproductive tract and to establish a receptive endometrium at the time of embryo implantation. The general approach was to compare steroid hormone responses and evaluate uterine receptivity in sexually mature control mice, that have AMPK in their reproductive tract, and the mutant mice. Immunohistochemistry and RT-qPCR were used to demonstrate that gene clusters associated with estrogen (E2) signaling, decidualization, cell cycle progression and inflammation were all differentially regulated in mutant uteri at the time of embryo implantation. These findings were also confirmed in an artificial model of uterine receptivity. To further verify that the ablation of AMPK from the female reproductive tract was in fact a uterine phenotype, we evaluated ovarian histology and serum progesterone (P4) of day of pregnancy 5 animals. The results showed no difference in serum P4 or ovarian histology between control and mutant mice suggesting that production of P4 occurs in an AMPK-independent fashion. Furthermore, uteri from mutant mice failed to respond properly to E2-induced epithelial proliferation, demonstrating that AMPK is a necessary mediator of E2 actions. These results define a new role for AMPK in the context of female reproduction.
Commentary of the SKLM to the EFSA opinion on risk assessment of N-nitrosamines in food : Gerhard Eisenbrand, Andrea Buettner, Patrick Diel, Bernd Epe, Petra Först, Tillman Grune, Dirk Haller, Volker Heinz, Michael Hellwig, Hans-Ulrich Humpf, Henry Jäger, Sabine Kulling, Alfonso Lampen, Marcel Leist, Angela Mally, Doris Marko, Ute Nöthlings, Elke Röhrdanz, Joachim Spranger, Pablo Steinberg, Stefan Vieths, Wim Wätjen, Jan G. Hengstler
Creators: name: Eisenbrand, Gerhard
name: Büttner, Andrea
name: Diel, Patrick Rene
name: Epe, Bernd
name: Först, Petra
name: Grune, Tillman
name: Haller, Dirk
name: Heinz, Volker
name: Hellwig, Michael
name: Humpf, Hans-Ulrich
name: Jäger, Henry
name: Kulling, Sabine E.
name: Lampen, Alfonso
name: Leist, Marcel
name: Mally, Angela
name: Marko, Doris
name: Nöthlings, Ute
name: Röhrdanz, Elke
name: Spranger, Joachim
name: Steinberg, Pablo
name: Vieths, Stefan
name: Wätjen, Wim
name: Hengstler, Jan G.
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 641

description: Dietary exposure to N-nitrosamines has recently been assessed by the European Food Safety Authority (EFSA) to result in margins of exposure that are conceived to indicate concern with respect to human health risk. However, evidence from more than half a century of international research shows that N-nitroso compounds (NOC) can also be formed endogenously. In this commentary of the Senate Commission on Food Safety (SKLM) of the German Research Foundation (DFG), the complex metabolic and physiological biokinetics network of nitrate, nitrite and reactive nitrogen species is discussed with emphasis on its influence on endogenous NOC formation. Pioneering approaches to monitor endogenous NOC have been based on steady-state levels of N-nitrosodimethylamine (NDMA) in human blood and on DNA adduct levels in blood cells. Further NOC have not been considered yet to a comparable extent, although their generation from endogenous or exogenous precursors is to be expected. The evidence available to date indicates that endogenous NDMA exposure could exceed dietary exposure by about 2–3 orders of magnitude. These findings require consolidation by refined toxicokinetics and DNA adduct monitoring data to achieve a credible and comprehensive human health risk assessment.
Systematic Review of Measures Used in Pictorial Cigarette Pack Warning Experiments
Creators: name: Brewer, Noel T
name: Francis, Diane B
name: Noar, Seth M
name: Ribisl, Kurt M
name: Hall, Marissa G
Publisher: name: Oxford University Press (OUP)
Year: 2017

description:
BACKGROUND: We sought to describe characteristics and psychometric properties of measures used in pictorial cigarette pack warning experiments and provide recommendations for future studies. METHODS: Our systematic review identified 68 pictorial cigarette pack warning experiments conducted between 2000 and 2016 in 22 countries. Two independent coders coded all studies on study features, including sample characteristics, theoretical framework, and constructs assessed. We also coded measurement characteristics, including construct, number of items, source, reliability, and validity. RESULTS: We identified 278 measures representing 61 constructs. The most commonly assessed construct categories were warning reactions (62% of studies) and perceived effectiveness (60%). The most commonly used outcomes were affective reactions (35%), perceived likelihood of harm (22%), intention to quit smoking (22%), perceptions that warnings motivate people to quit smoking (18%), and credibility (16%). Only 4 studies assessed smoking behavior. More than half (54%) of all measures were single items. For multi-item measures, studies reported reliability data 68% of the time (mean α = 0.88, range α = 0.68-0.98). Studies reported sources of measures only 33% of the time and rarely reported validity data. Of 68 studies, 37 (54%) mentioned a theory as informing the study. CONCLUSIONS: Our review found great variability in constructs and measures used to evaluate the impact of cigarette pack pictorial warnings. Many measures were single items with unknown psychometric properties. Recommendations for future studies include a greater emphasis on theoretical models that inform measurement, use of reliable and validated (preferably multi-item) measures, and better reporting of measure sources. IMPLICATIONS: Robust and consistent measurement is important for building a strong, cumulative evidence base to support pictorial cigarette pack warning policies. This systematic review of experimental studies of pictorial cigarette warnings demonstrates the need for standardized, theory-based measures.
Digitalisierung in der Pflege
Creators: name: Thilo, Friederike J.S.
Publisher: name: Schweizer Berufsverband der Pflegefachfrauen und Pflegefachmänner
Year: 2024

description: Die digitale Transformation ist in aller Munde. Manche sehen dem technologischen Fortschritt mit Freude entgegen, andere fürchten, dass der Pflegeberuf dadurch entwertet wird oder das Wohl der Patient:innen aus dem Blick verloren gehen könnte.
Thinning effects under an upper diameter restriction on size class diversity and future demography of dry-pine and mixed-conifer forests in the Silver Lake Ranger District, Fremont-Winema NF
Creators: name: ALEXANDER, SEAN M
Publisher: name: Washington State University
Year: 2020
Subjects: Forest management--West (U.S.)
Forest fires--Prevention and control
Fremont-Winema National Forest (Or.)
Oregon--Fremont-Winema National Forest
Forest Management

description: Silvicultural prescriptions to mechanically treat fire-prone forests and restore historical conditions have been a central management focus throughout the dry forest types of western North America. To guide forest restoration, federal policies have placed restrictions on harvesting trees of a given diameter, called upper-diameter caps, to preserve remaining large trees. Strict regulations constrict decisions that managers can make when implementing treatments and may have unintended implications towards restoring historic diameter distributions and age proportions. Diameter data from a number of treated and untreated stands in the Silver Lake Ranger district of the Fremont National Forest across both the more xeric dry pine type and a more mesic mixed conifer type were compared to each other and to reference old-growth stands. It was found that thinning with a diameter cap in place reduced values from several measures of diameter distribution diversity. This effect was persistent after fifty years of modeled stand development. The dry pine type experienced great simplification of diameter distributions through restoration than did the mixed conifer type. Tree core data revealed that 25% of ponderosa pine trees in the dry pine forest type met age criteria of old-growth yet not protected by the upper diameter cap. Thinning with a diameter cap may reduce risk of stand-replacing fire and help restore large tree populations but may not recreate diameter distributions and tree age proportions reflective of historic old-growth forests.
How people think about the chemicals in cigarette smoke: a systematic review
Creators: name: Brewer, Noel T.
name: Morgan, Jennifer C.
name: Stepanov, Irina
name: Byron, M. Justin
name: Baig, Sabeeh A.
Publisher: name: Springer Nature
Year: 2017

description:
Laws and treaties compel countries to inform the public about harmful chemicals (constituents) in cigarette smoke. To encourage relevant research by behavioral scientists, we provide a primer on cigarette smoke toxicology and summarize research on how the public thinks about cigarette smoke chemicals. We systematically searched PubMed in July 2016 and reviewed citations from included articles. Four central findings emerged across 46 articles that met inclusion criteria. First, people were familiar with very few chemicals in cigarette smoke. Second, people knew little about cigarette additives, assumed harmful chemicals are added during manufacturing, and perceived cigarettes without additives to be less harmful. Third, people wanted more information about constituents. Finally, well-presented chemical information increased knowledge and awareness and may change behavior. This research area is in urgent need of behavioral science. Future research should investigate whether educating the public about these chemicals increases risk perceptions and quitting.
Carcass and meat quality of finished and non-finished Limousin heifers from alpine livestock systems differing in altitudinal origin of the forage
Creators: name: Kreuzer, Michael
name: Gangnat, Isabelle Diane Marie
name: Clavijo McCormick, Andrea
name: Leiber, Florian
name: Berard, Joel
Publisher: name: Taylor & Francis
Year: 2016

description: Effects of the alpine origin of the forage and of finishing on carcass and beef quality were quantified by modelling different alpine livestock system alternatives. Thirty-five Limousin heifers, initially weighing 383 ± 45 kg, were fed fresh grass at 400 or 2000 m above sea level, or a 1:1 mixture of alpine grass and lowland grass hay at 2000 m. After 9 weeks, the six heaviest and oldest animals per group were slaughtered. The remaining animals were finished for 8 weeks on a silage-concentrate diet in the lowlands to similar age and body weight as the first slaughtered group. Carcass and meat quality (M. longissimus thoracis) were assessed in various respects. The average daily gains achieved were of about 600 g/d and similar between forage-type groups. Dressing percentage was 53.5% in the alpine and 57.2% in the lowland group. Carcass conformation and fat cover scores did not differ between forage-type groups. The meat from the alpine groups had greater ultimate pH and smaller redness, yellowness and protein contents. Still, these differences were of minor practical relevance. There was no forage-type effect on water-holding capacity and shear force of the meat. The alpine systems enhanced the proportion of α-linolenic acid in intramuscular fat and decreased the levels of some volatile compounds in perirenal fat. Finishing resulted in compensatory growth, especially in the animals previously fed lowland grass. There was a trend for the finished compared with the non-finished groups towards greater carcass fat cover and intramuscular fat content. Additionally, ultimate pH was smaller and cooking loss was greater with than without finishing. Meat colour differences were also observed. Shear force was not affected by finishing. The finished animals had a smaller α-linolenic acid proportion in the intramuscular fat. In conclusion, the forage type had small effects on carcass and meat quality. Finishing did not substantially improve carcass and meat quality. The (alpine) grass-specific differences in fatty acid profile found in the unfinished cattle were not present in the finished animals.
Atrypanius spretus Monné & Santos-Silva & Monné 2020, comb. nov.
Creators: name: Monné, Miguel A.
name: Santos-Silva, Antonio
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Atrypanius
Atrypanius spretus

description: Atrypanius spretus (Bates, 1864), comb. nov.
(Figs. 128–130)
Nyssodrys spreta Bates, 1864b: 152.
Nyssodrysina spreta; Monné & Giesbert, 1992: 253.
Type locality— Holotype male: Brazil, Pará: Santarém (MNHN).
Nyssodrysola stictica Gilmour, 1962: 257.
Type locality— Holotype male: Peru, Junin: Satipo (AMNH).
Urgleptes halffteri Villiers, 1971: 348.
Type locality— Holotype male: French Guiana, Bord d’Acarouany Massikiri, Oyapock (MNHN).
Distribution— Ecuador, French Guiana, Brazil (Amazonas, Pará, Rondônia), Peru, Bolivia (Beni, Cochabamba, Santa Cruz).
Remarks. Tavakilian (1991) synonymized Urgleptes halffteri with Nyssodrysola stictica, and transferred the species to Nyssodrysina. Monné & Giesbert (1992) synonymized Nyssodrysola stictica with Nyssodrysina spreta. Tavakilian & Chevillotte (2020) show these three species in Nyssodrysina, but U. halffteri and N. stictica were never formally revalidated.
description: Published as part of Monné, Miguel A., Santos-Silva, Antonio & Monné, Marcela L., 2020, Key to South American genera of Acanthocinini (Coleoptera, Cerambycidae, Lamiinae) without erect setae on elytra; synonymies, transferences, revalidation, and notes on genera with erect setae on elytra, pp. 1-65 in Zootaxa 4863 (1) on page 26, DOI: 10.11646/zootaxa.4863.1.1, http://zenodo.org/record/4416817
Threat of mining to African great apes
Creators: name: Junker, Jessica
name: Quoss, Luise
name: Valdez, Jose
name: Arandjelovic, Mimi
name: Barrie, Abdulai
name: Campbell, Geneviève
name: Heinicke, Stefanie
name: Humle, Tatyana
name: Kouakou, Célestin Y.
name: Kühl, Hjalmar
name: Ordaz-Németh, Isabel
name: Pereira, Henrique M.
name: Rainer, Helga
name: Refisch, Johannes
name: Sonter, Laura
name: Sop, Tene Kwetche
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 590

description: The rapid growth of clean energy technologies is driving a rising demand for critical minerals. In 2022 at the 15th Conference of the Parties to the Convention on Biological Diversity (COP15), seven major economies formed an alliance to enhance the sustainability of mining these essential decarbonization minerals. However, there is a scarcity of studies assessing the threat of mining to global biodiversity. By integrating a global mining dataset with great ape density distribution, we estimated the number of African great apes that spatially coincided with industrial mining projects. We show that up to one-third of Africa’s great ape population faces mining-related risks. In West Africa in particular, numerous mining areas overlap with fragmented ape habitats, often in high-density ape regions. For 97% of mining areas, no ape survey data are available, underscoring the importance of increased accessibility to environmental data within the mining sector to facilitate research into the complex interactions between mining, climate, biodiversity, and sustainability.
Global indicators of the environmental impacts of invasive alien species and their information adequacy
Creators: name: Henriksen, Marie V.
name: Arlé, Eduardo
name: Pili, Arman
name: Clarke, David A.
name: García-Berthou, Emili
name: Groom, Quentin
name: Lenzner, Bernd
name: Meyer, Carsten
name: Seebens, Hanno
name: Tingley, Reid
name: Winter, Marten
name: McGeoch, Melodie A.
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 550

description: Monitoring the extent to which invasive alien species (IAS) negatively impact the environment is crucial for understanding and mitigating biological invasions. Indeed, such information is vital for achieving Target 6 of the Kunming–Montreal Global Biodiversity Framework. However, to-date indicators for tracking the environmental impacts of IAS have been either lacking or insufficient. Capitalizing on advances in data availability and impact assessment protocols, we developed environmental impact indicators to track realized and potential impacts of IAS. We also developed an information status indicator to assess the adequacy of the data underlying the impact indicators. We used data on 75 naturalized amphibians from 82 countries to demonstrate the indicators at a global scale. The information status indicator shows variation in the reliability of the data and highlights areas where absence of impact should be interpreted with caution. Impact indicators show that growth in potential impacts are dominated by predatory species, while potential impacts from both predation and disease transmission are distributed worldwide. Using open access data, the indicators are reproducible and adaptable across scales and taxa and can be used to assess global trends and distributions of IAS, assisting authorities in prioritizing control efforts and identifying areas at risk of future invasions.
Domestication has altered gene expression and secondary metabolites in pea seed coat
Creators: name: Klčová, Barbora
name: Balarynová, Jana
name: Trněný, Oldřich
name: Krejčí, Petra
name: Cechová, Monika Zajacová
name: Leonova, Tatiana
name: Gorbach, Daria
name: Frolova, Nadezhda
name: Kysil, Elana
name: Orlova, Anastasia
name: Ihling, Сhristian
name: Frolov, Andrej
name: Smýkal, Petr
name: Bednář, Petr
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 580

description: The mature seed in legumes consists of an embryo and seed coat. In contrast to knowledge about the embryo, we know relatively little about the seed coat. We analyzed the gene expression during seed development using a panel of cultivated and wild pea genotypes. Gene co-expression analysis identified gene modules related to seed development, dormancy, and domestication. Oxidoreductase genes were found to be important components of developmental and domestication processes. Proteomic and metabolomic analysis revealed that domestication favored proteins involved in photosynthesis and protein metabolism at the expense of seed defense. Seed coats of wild peas were rich in cell wall-bound metabolites and the protective compounds predominated in their seed coats. Altogether, we have shown that domestication altered pea seed development and modified (mostly reduced) the transcripts along with the protein and metabolite composition of the seed coat, especially the content of the compounds involved in defense. We investigated dynamic profiles of selected identified phenolic and flavonoid metabolites across seed development. These compounds usually deteriorated the palatability and processing of the seeds. Our findings further provide resources to study secondary metabolism and strategies for improving the quality of legume seeds which comprise an important part of the human protein diet.
Philetus
Creators: name: Cumming, Jeffrey M.
name: Brooks, Scott E.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Empididae
Philetus

description: Key to species of Philetus (males)
1 Terminalia with cercus bifid apically; hypandrium without apical rods; postgonite projected dorsally as broad U-shaped lobe (Cumming et al. 2016, figs 17–20). Antenna with postpedicel broadly produced apically (Cumming et al. 2016, fig. 8)..................................................................................... P. schizophorus Melander
- Terminalia with cercus simple, elongate, not bifid apically (Figs 3, 5); hypandrium with hooked-shaped apical rods (Fig. 4); postgonite projected dorsally as wide rounded lobe (Fig. 4). Antenna with postpedicel narrowly produced apically (Cumming et al. 2016, fig. 7)..................................................................................... 2
2 Terminalia with cercus rounded apically, without pronounced apical ventral hook (Fig. 3); ventral subepandrial lobe with digitiform apex and thumb-like preapical medially-directed process (Fig. 5); medial subepandrial lobe absent; epandrial lobe with posteriorly hooked dorsal process (Figs 3, 5); hypandrium with narrow median apical process (Figs 3, 4)..... P. kitsi sp. nov.
- Terminalia with cercus bearing pronounced apical ventral hook; ventral subepandrial lobe with broadly deflexed apex, lacking preapical medially-directed process; medial subepandrial lobe present; epandrial lobe with bifid dorsal process; hypandrium with thick median apical process (Cumming et al. 2016, figs 13–16).......................... P. memorandus Melander
description: Published as part of Cumming, Jeffrey M. & Brooks, Scott E., 2020, A new species of Philetus Melander (Diptera: Empididae) from the Yukon Territory, Canada, pp. 447-450 in Zootaxa 4718 (3) on pages 448-449, DOI: 10.11646/zootaxa.4718.3.12, http://zenodo.org/record/3751922
The circular economy rebound effect : reconceptualizing rebound approaches and mitigation opportunities from an ordonomic perspective
Creators: name: Schultz, Felix Carl
name: Valentinov, Vladislav
name: Reinhardt, Robert Jaroslav
name: Pies, Ingo
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 330

description: Recent scholarship has advocated a conceptual investigation of rebound effect theory in the circular economy (CE) context. While the available body of knowledge on a circular economy rebound (CER) is rather scant, this forum article proposes a conceptual view of existing CER approaches. Our analysis reveals that the CER literature has largely bypassed an appreciation of how firm behavior is embedded in and canalized by governance arrangements. This forum article contributes to the literature by reconceptualizing the challenges of mitigating CERs. It proposes to re-focus the CER debate toward: (i) the innovation need of functional collective commitments for CE to address free-rider-problems; (ii) the criticality of effective management of decoupling through innovative circular governance; (iii) the critical reflection of calls for degrowth and “non-optimization” behavior; and (iv) the recognition of optimization behavior and circular governance frameworks as complementary rather than substitute approaches for facilitating CER mitigation.
Influences of habitat characteristics on forage resources of Rocky Mountain elk (Cervus canadensis) in north-central Idaho
Creators: name: Monzingo, Deborah Suzanne
Publisher: name: Washington State University
Year: 2020
Subjects: Rocky Mountain elk--Food--Idaho--Clearwater River Valley
Rocky Mountain elk--Food--Idaho--Saint Joe River Watershed
Idaho--Clearwater River Valley
Idaho--Saint Joe River Watershed

description: Populations of Rocky Mountain elk (Cervus canadensis) in Idaho have been decreasing since the 1990's. Natural resource organizations seek to determine the cause and opportunities for management. Changes in natural disturbances have altered the abundance of nutritious forage through changes in succession, potentially contributing to elk population declines. We modeled elk forage quantity and quality during summer in relation to stand age, overstory canopy cover, potential vegetation (PV) zone, phenology, and biophysical covariates within North-central Idaho's Clearwater and St. Joe Basins. In summers of 2016-17, we measured overstory and understory characteristics within 359, 0.18-ha macroplots. Using conversions based on double-sampling, we estimated understory vegetation for all plants in each macroplot from estimations of horizontal plant cover (mean pseudo R2 0.63, ranging from 0.25 - 0.99). We collected understory vegetation samples and analyzed them for digestible energy (DE) and digestible protein (DP) content. Using understory biomass, DE and DP content, and prior knowledge of elk diet selection and nutritional constraints, we developed 8 forage resources for elk that differed in how they incorporated forage quality and quantity. We examined the effects of succession on forage resources and compared how different forage resources responded to biogeoclimatic gradients. For most PV zones, overstory canopy cover increased during the first 20 - 50 years before reaching an asymptote. The wetter PV zones increased more rapidly and reached a higher (~ 80%) asymptotic overstory canopy cover than the drier zones (~ 50%). In contrast, the highest abundance of understory vegetation and forage resources in most PV zones occurred during the first 20 years and declined as the overstory closed. Peak understory biomass ranged from 500 - 1,000 kg/ha. We then created models predicting these forage resource metrics, which varied among PV zones (mean R2 ranged from 0.24 - 0.65), with better predictions for wetter PV zones. These predictive models can be used to develop spatially explicit elk nutritional landscapes. Such 'foodscapes' are critical for developing habitat management plans, assessing the drivers of elk density and fitness, and evaluating the effect of past and future disturbances on elk in the Clearwater and St. Joe Basins, Idaho.
Additional file 3 of Evolutionary history of phosphatidylinositol- 3-kinases: ancestral origin in eukaryotes and complex duplication patterns
Creators: name: Philippon, Héloïse
name: Brochier-Armanet, Céline
name: Perrière, Guy
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Number of gaps per sequence after site selection for the reduced catalytic dataset. Sequences are sorted by increased percentage of gaps.
Nα-aroyl-N-aryl-phenylalanine amides: a promising class of antimycobacterial agents targeting the RNA polymerase
Creators: name: Seidel, Rüdiger W.
name: Goddard, Richard W.
name: Lang, Markus
name: Richter, Adrian
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 615

description: Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains the leading cause of death from a bacterium in the world. The global prevalence of clinically relevant infections with opportunistically pathogenic non-tuberculous mycobacteria (NTM) has also been on the rise. Pharmacological treatment of both TB and NTM infections usually requires prolonged regimens of drug combinations, and is often challenging because of developed or inherent resistance to common antibiotic drugs. Medicinal chemistry efforts are thus needed to improve treatment options and therapeutic outcomes. Nα-aroyl-N-aryl-phenylalanine amides (AAPs) have been identified as potent antimycobacterial agents that target the RNA polymerase with a low probability of cross resistance to rifamycins, the clinically most important class of antibiotics known to inhibit the bacterial RNA polymerase. In this review, we describe recent developments in the field of AAPs, including synthesis, structural characterization, in vitro microbiological profiling, structure-activity relationships, physicochemical properties, pharmacokinetics and early cytotoxicity assessment.
Additional file 8 of Evolutionary history of phosphatidylinositol- 3-kinases: ancestral origin in eukaryotes and complex duplication patterns
Creators: name: Philippon, Héloïse
name: Brochier-Armanet, Céline
name: Perrière, Guy
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Number of gaps per sequence after site selection for the MIC class I catalytic subunit dataset. Sequences are sorted by increased percentage of gaps.
External post-mortem examination in virtual reality : scalability of a monocentric application
Creators: name: Klus, Christina
name: Krumm, Katja
name: Jacobi, Sindy
name: Willemer, Marie-Christin
name: Daub, Charlotte
name: Stoevesandt, Dietrich
name: Metzler, Katrin
name: Richter, Carolin
name: Peter, Lisa-Maria
name: Heide, Steffen
name: Schmidt, Uwe
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 610

description: Conducting external post-mortem examinations is an essential skill required of physicians in various countries, regardless of their specialization. However, the quality of these examinations has been a subject of continuous debates, and notable errors were reviled. In response to these shortcomings, a virtual reality (VR) application was developed at Halle's medical department in Germany, focusing on the scene of discovery and the completion of death certificates. The initial trial of this VR application in 2020 involved 39 students and 15 early-career professionals. Based on the feedback, the application underwent improvements and was subsequently introduced to the medical department in Dresden, Germany, in 2022. Its primary objective was to showcase the VR training's adaptability and scalability across various educational structures and levels of medical expertise. Out of 73 students who participated, 63 completed the evaluation process. 93.1% (n = 58) of the evaluators reported increased confidence in conducting external post-mortem examinations, and 96.8% (n = 61) felt more assured in filling out death certificates, crediting this progress to the VR training. Additionally, 98.4% (n = 62) believed that repeating forensic medical aspects in their coursework was crucial, and 96.8% (n = 61) viewed the VR examination as a valuable addition to their academic program. Despite these positive responses, 91.6% (n = 55) of participants maintained that training with real corpses remains irreplaceable due to the insufficiency of haptic feedback in VR. Nevertheless, the potential for enhancing the VR content and expanding the training to additional locations or related disciplines warrants further exploration.
Whispering gallery mode lasers for sensing force in biological systems
Creators: name: Hill, Joseph Samuel
Publisher: name: The University of St Andrews
Year: 2023
Subjects: Microlaser
Deformable laser
Droplet laser
Micro-force sensor
Mechanical sensor
Whispering gallery mode laser

description: The burgeoning field of mechanobiology has given rise to many new discoveries in recent years. There has been an expansion in the devices created to measure the nanoscopic forces cells and developing organisms use to interact with their surroundings. Whispering gallery mode (WGM) lasers have also been an expanding area of research recently because of the excellent laser characteristics they can provide at microscopic scales. This study investigates the use of microscopic deformable WGM droplet lasers as a probe for force sensing in biological systems. A complete fabrication and analysis method is demonstrated showing that droplet microlasers are a tool that can be implemented in many biological systems. Droplet microlasers are used as an intracellular and extracellular force sensor. Further, the droplet microlasers are used to measure in vivo forces within Drosophila melanogaster larvae. The analysis protocol models the splitting of non-degenerate laser modes to determine the geometry of a deformed droplet microlaser. Combining the geometry and mechanical properties of the droplet microlaser allows an applied force to be inferred. The droplet microlasers developed can measure forces within single cells showing a clear difference in force between interactive and non-interactive cells. As an extracellular sensor, the droplet microlasers measured the response time of the force rat aortic smooth muscle cells (RASMCs) applied to their extracellular matrix when a drug (sodium nitroprusside) is applied. The magnitude of the forces sensed by the droplet microlasers can be adjusted by tuning its mechanical properties. Forces between 250 pN to 7 nN were measured. Further, it is demonstrated that the droplet microlasers can sense deeper than any other light-based force sensor, recording measurements at 300 μm deep within a 3rd instar Drosophila melanogaster larva at an acquisition rate of 10 Hz.
Wenn man an einem dunklen Ort wieder Licht sieht
Creators: name: Chiapparini, Emanuela
name: Schuwey, Claudia
name: Müller De Menezes, Rahel
Publisher: name: Berner Fachhochschule, Soziale Arbeit
Year: 2021

description: Personen mit Migrations- und Fluchthintergrund sind auf niederschwellige Angebote zum Thema Psychische Gesundheit angewiesen. Diese sind in der Schweiz jedoch rar. Das seit 1994 bestehende Programm «Femmes-Tische und Männer-Tische» hat hier eine Vorreiterrolle inne und bietet in über 20 Sprachen Gesprächsrunden an.
Mycorrhizal type and tree diversity affect foliar elemental pools and stoichiometry
Creators: name: Bönisch, Elisabeth
name: Blagodatskaya, Evgenia
name: Dirzo, Rodolfo
name: Ferlian, Olga
name: Fichtner, Andreas
name: Huang, Yuanyuan
name: Leonard, Samuel J.
name: Maestre, Fernando
name: Oheimb, Goddert
name: Ray, Tama
name: Eisenhauer, Nico
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 580

description: Species-specific differences in nutrient acquisition strategies allow for complementary use of resources among plants in mixtures, which may be further shaped by mycorrhizal associations. However, empirical evidence of this potential role of mycorrhizae is scarce, particularly for tree communities. We investigated the impact of tree species richness and mycorrhizal types, arbuscular mycorrhizal fungi (AM) and ectomycorrhizal fungi (EM), on above- and belowground carbon (C), nitrogen (N), and phosphorus (P) dynamics. Soil and soil microbial biomass elemental dynamics showed weak responses to tree species richness and none to mycorrhizal type. However, foliar elemental concentrations, stoichiometry, and pools were significantly affected by both treatments. Tree species richness increased foliar C and P pools but not N pools. Additive partitioning analyses showed that net biodiversity effects of foliar C, N, P pools in EM tree communities were driven by selection effects, but in mixtures of both mycorrhizal types by complementarity effects. Furthermore, increased tree species richness reduced soil nitrate availability, over 2 yr. Our results indicate that positive effects of tree diversity on aboveground nutrient storage are mediated by complementary mycorrhizal strategies and highlight the importance of using mixtures composed of tree species with different types of mycorrhizae to achieve more multifunctional afforestation.
A content analysis of HPV vaccination messages available online
Creators: name: Robichaud, Meagan
name: Calo, William A
name: Brewer, Noel T
name: Malo, Teri L
name: Gilkey, Melissa B
Publisher: name: Elsevier
Year: 2018

description:
Parents have varied HPV vaccine communication needs, which presents a challenge for healthcare providers. To improve communication resources for providers, we sought to characterize HPV vaccination messages available in existing educational materials. In fall 2016, we searched PubMed, educational material clearinghouses, and Google for English language HPV vaccination messages. We extracted messages that a provider might use when raising the topic of HPV vaccination, answering common questions, and motivating vaccination. Two reviewers independently coded each message. The search identified 267 unique messages about HPV vaccination. Messages generally were long (mean no. of words = 44, standard deviation [SD] = 33) and required a high level of education to read (mean reading grade level = 10, SD = 3). Only 32% of messages were shorter than 25 words, and 12% had a readability at or below grade 6. Most frequent were messages to address common parent questions or concerns (62%); the most common topics were diseases prevented by HPV vaccine (18%) and safety and side effects (16%). Many messages included information about cancer prevention (26%) and same-day vaccination (13%). Few messages (6%) used a presumptive style to recommend HPV vaccination. In conclusion, available messages about HPV vaccination were markedly varied. We identified few messages that were both brief (to facilitate providers memorizing them) and accessible (to facilitate parents understanding them). Future research should identify which messages lead to HPV vaccine uptake.
Additional file 5 of Evolutionary history of phosphatidylinositol- 3-kinases: ancestral origin in eukaryotes and complex duplication patterns
Creators: name: Philippon, Héloïse
name: Brochier-Armanet, Céline
name: Perrière, Guy
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Number of gaps per sequence after site selection for the regulatory subunit class IA dataset. Sequences are sorted by increased percentage of gaps.
Additional file 11 of Evolutionary history of phosphatidylinositol- 3-kinases: ancestral origin in eukaryotes and complex duplication patterns
Creators: name: Philippon, Héloïse
name: Brochier-Armanet, Céline
name: Perrière, Guy
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Phylogenetic tree of Metazoa, Ichthyosporea and Choanoflagellida homologs of class II catalytic proteins. The tree was inferred with the JTT+ Γ 4 model (1113 sites, 108 sequences). Sequences are colored according to their taxonomic classification. Branch statistical supports and duplication events are shown using the same symbols as in Fig. 1. As described in the Material and methods section, we selected all non-mammal species from Ensembl, and kept ten representative mammal organisms and all Ichtyosporea, Choanoflagellida and Metazoa species from our local database.
Insights into early recovery from Long COVID : results from the German DigiHero Cohort
Creators: name: Diexer, Sophie
name: Klee, Bianca
name: Gottschick, Cornelia
name: Broda, Anja
name: Purschke, Oliver
name: Binder, Mascha
name: Gekle, Michael
name: Girndt, Matthias
name: Höll, Jessica
name: Moor, Irene
name: Sedding, Daniel
name: Rosendahl, Jonas
name: Mikolajczyk, Rafael
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 610

description: 65 million people worldwide are estimated to suffer from long-term symptoms after their SARS-CoV-2 infection (Long COVID). However, there is still little information about the early recovery among those who initially developed Long COVID, i.e. had symptoms 4–12 weeks after infection but no symptoms after 12 weeks. We aimed to identify associated factors with this early recovery. We used data from SARS-CoV-2-infected individuals from the DigiHero study. Participants provided information about their SARS-CoV-2 infections and symptoms at the time of infection, 4–12 weeks, and more than 12 weeks post-infection. We performed multivariable logistic regression to identify factors associated with early recovery from Long COVID and principal component analysis (PCA) to identify groups among symptoms. 5098 participants reported symptoms at 4–12 weeks after their SARS-CoV-2 infection, of which 2441 (48%) reported no symptoms after 12 weeks. Men, younger participants, individuals with mild course of acute infection, individuals infected with the Omicron variant, and individuals who did not seek medical care in the 4–12 week period after infection had a higher chance of early recovery. In the PCA, we identified four distinct symptom groups. Our results indicate differential risk of continuing symptoms among individuals who developed Long COVID. The identified risk factors are similar to those for the development of Long COVID, so people with these characteristics are at higher risk not only for developing Long COVID, but also for longer persistence of symptoms. Those who sought medical help were also more likely to have persistent symptoms.
Predictors of Human Papillomavirus Vaccine Follow-Through Among Privately Insured US Patients.
Creators: name: Wheeler, Stephanie B
name: Dusetzina, Stacie B
name: Spencer, Jennifer C
name: Brewer, Noel T
name: Trogdon, Justin G
Publisher: name: American Public Health Association
Year: 2018

description:
OBJECTIVES: To assess predictors of timely human papillomavirus (HPV) vaccine follow-through among privately insured individuals initiating the 3-dose series. METHODS: Using MarketScan Commercial claims data, we identified 1 332 217 privately insured US individuals aged 9 to 26 years who initiated the bivalent or quadrivalent HPV vaccine series from 2006 to 2014, with follow-up data extending through 2015. The study outcome was receipt of third HPV dose within 12 months of the first, compared by year of initiation. Control variables were age, region, insurance plan type, provider type, and seasonal influenza vaccination. RESULTS: Timely HPV vaccine follow-through fell over time. The trend was especially pronounced for females (from 67% in 2006 to 38% in 2014), but was also present for males (from 36% in 2011 to 33% in 2014). Similar patterns were present when we controlled for patient and provider characteristics or used alternative definitions of follow-through. Other positive predictors of timely follow-through included receipt of flu vaccine in the prior year and receipt of first HPV vaccine dose from an obstetrician/gynecologist. CONCLUSIONS: HPV vaccine follow-through is low and has declined over time.
Additional file 4 of Evolutionary history of phosphatidylinositol- 3-kinases: ancestral origin in eukaryotes and complex duplication patterns
Creators: name: Philippon, Héloïse
name: Brochier-Armanet, Céline
name: Perrière, Guy
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Number of gaps per sequence after site selection for the regulatory subunit class III dataset. Sequences are sorted by increased percentage of gaps.
Admittance Control of the Ankle Mechanism in a Rotational Orthosis for Walking with Arm Swing
Creators: name: Mu, Zaile
name: Fang, Juan
name: Zhang, Qiuju
Publisher: name: IEEE
Year: 2019

description: In order to provide an effective system for rehabilitation of walking, a new rotational orthosis for walking with arm swing, called ROWAS II, was developed. This study focused on development and implementation of admittance control of the ankle mechanism in the ROWAS II system for promoting active training. Firstly, the mechanical structure of the ankle mechanism is briefly introduced. Then the algorithms of the closed-loop position control and the admittance control for the ankle mechanism are described in detail. Four able-bodied participants were recruited to use the ankle mechanism running in passive and active modes. The experimental results showed that the ankle mechanism well tracked the target trajectory in passive mode. In active mode, the participants interacted with the ankle mechanism, and adjusted their ankle movement based on their active force. The ankle mechanism has the technical potential to meet the requirements of passive and active training in the ankle movement for patients in different post-stroke stages.
Childhood and adolescence factors and multiple sclerosis : results from the German National Cohort (NAKO)
Creators: name: Holz, Anja
name: Obi, Nadia
name: Ahrens, Wolfgang
name: Berger, Klaus
name: Bohn, Barbara
name: Brenner, Hermann
name: Fischer, Beate
name: Fricke, Julia Bettina
name: Führer, Amand-Gabriel
name: Gastell, Sylvia
name: Greiser, Karin Halina
name: Harth, Volker
name: Heise, Jana-Kristin
name: Holleczek, Bernd
name: Keil, Thomas
name: Klett-Tammen, Carolina Judith
name: Leitzmann, Michael
name: Lieb, Wolfgang
name: Meinke-Franze, Claudia
name: Michels, Karin
name: Mikolajczyk, Rafael
name: Nimptsch, Katharina
name: Peters, Annette
name: Pischon, Tobias
name: Riedel, Oliver
name: Schikowski, Tamara
name: Schipf, Sabine
name: Schmidt, Börge
name: Schulze, Matthias B.
name: Stang, Andreas
name: Hellwig, Kerstin
name: Riemann-Lorenz, Karin
name: Heesen, Christoph
name: Becher, Heiko
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 610

description: Multiple Sclerosis (MS) represents the most common inflammatory neurological disease causing disability in early adulthood. Childhood and adolescence factors might be of relevance in the development of MS. We aimed to investigate the association between various factors (e.g., prematurity, breastfeeding, daycare attendance, weight history) and MS risk.
Atrypanius venustus Monné & Santos-Silva & Monné 2020, comb. nov.
Creators: name: Monné, Miguel A.
name: Santos-Silva, Antonio
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Atrypanius
Atrypanius venustus

description: Atrypanius venustus (Bates, 1863), comb. nov.
Lepturges venustus Bates, 1863c: 372.
Nyssodrysina venusta; Monné, 1985: 547.
Type locality — Syntypes male and female: Brazil, Amazonas: Ega [Tefé] (MNHN). Distribution — Nicaragua, Ecuador, French Guiana, Brazil (Amazonas, Pará, Rondônia), Bolivia (Santa Cruz).
description: Published as part of Monné, Miguel A., Santos-Silva, Antonio & Monné, Marcela L., 2020, Key to South American genera of Acanthocinini (Coleoptera, Cerambycidae, Lamiinae) without erect setae on elytra; synonymies, transferences, revalidation, and notes on genera with erect setae on elytra, pp. 1-65 in Zootaxa 4863 (1) on page 26, DOI: 10.11646/zootaxa.4863.1.1, http://zenodo.org/record/4416817