cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Targeted Delivery of Small Interfering RNA (siRNA) Against Oncogenes by using pH-Sensitive Nanoparticles to Inhibit Breast Cancer Cells Proliferation and Survival
Creators: name: NUR IZYANI KAMARUZMAN
Publisher: name: Monash University
Year: 2019
Subjects: subject: Molecular Biology
subject: 100709 Nanomedicine
subject: FOS: Nanotechnology

description: Harnessing siRNA technology has promising results in limiting the proliferation and survival of cancer cells by ‘silencing’ the expression of targeted genes. Carbonate apatite nanoparticle system has been employed to electrostatically complex with the siRNAs in order to prevent their degradation and renal clearance, and enhance the uptake by target cells following intravenous administration. This study would have significant impact in validating the potential applications of pH-sensitive carbonate apatite nanoparticles for delivery of siRNA cocktails in different models of breast cancer as well as in clinical trials.
Study on The Production and Economic Analysis of Particleboard from Sugarcane Bagasse
Creators: name: Komah, Berhe
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2018

description: The reutilization of sugarcane bagasse residues to obtain an applicable product of particleboard is a very useful practice that generates many advantages in the evaluation of social areas, expanding baselines for economic applications, with a low cost product which is ecological and far less polluting. The objective of this work was to produce and evaluate feasibility of particleboard from sugarcane bagasse. The prepared bagasse was dried. After drying bagasse the true fibers must be separated from the pith component of bagasse. An operation usually known as sieving analysis. The bagasse fibers were mixed with urea formaldehyde resin. The mixture of fibers, resin, and any additives is pressed into boards which are subsequently trimmed and finished to form the final product. From result and discussion, Design-Expert 7.0.0 three-levelthree-factor CCD was applied for experimental design and statistical analysis of results. A total of 17 experiments were conducted at conditions of adhesive content 9%, 12 and 15% , targeted density 0.6g/cm3, 0.65g/cm3and 0.7g/cm3 and pressure of 35bar, 40bar and45 bar. From the analysis of experimental results the interaction effects were studied and optimization of process factors was done. Maximum response variables were found. It was observed that mechanical properties of the bagasse particleboard increased with an increase in resin content, density and pressing pressure. The maximum result was obtained with resin content 15%, density 0.7g/cm ix 3 and pressing pressure of 45bar. Under these conditions maximum modulus of rapture and internal bonding was 14.5674Mpa and0.41Mpa respectively, a satisfactory result as compared with literature data. From our preliminary cost analysis, this project is feasible. A payback period of 2 years is an indication of a promising and feasible plant.
The Application of Population Genetics to Facilitate Elimination of River Blindness in Africa
Creators: name: Crawford, Katie Elizabeth
Publisher: name: La Trobe
Year: 2023

description: Submission note: A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Life Sciences, College of Science, Health and Engineering, La Trobe University, Victoria, Australia.

The filarial parasitic nematode Onchocerca volvulus causes the disease onchocerciasis, with 204 million people at risk of infection, mainly in Africa. Mass drug administration with ivermectin has been implemented for up to 30 years in some communities with an aim of elimination. Before stopping treatment, elimination thresholds within a transmission zone need to be met; thus, defining transmission zone boundaries is integral to stop-treatment decisions. However, current transmission zone definitions do not incorporate possible parasite migration. Furthermore, once treatment has been stopped, distinguishing between new and on-going infection by reproductively active females indicates whether transmission has ceased, yet there is no current method for detecting new infections. Population genetics is a tool for genetic epidemiology that could answer these questions, but no studies have done so in O. volvulus. I tested the hypothesis that O. volvulus has geographically large transmission zones. The mitochondrial genomes of 189 adult O. volvulus samples from West Africa were sequenced and analysed. Population structure indicates that transmission zones are geographically large ( greater than 100-200km) which may compromise the long-term sustainability of elimination if treatment ceases prematurely. Microfilariae are routinely collected during onchocerciasis elimination surveillance, and so a similar approach was adapted for this more epidemiologically practical life stage. Analysing sequence data from microfilariae from 48 individual patients from Central Africa indicated that transmission zone size is similar to those in West Africa. The use of microfilariae also enabled the estimation of the number of actively reproducing female worms per patient (average 3.19). Estimates of the active female worm population size could be a valuable adjunct to current disease surveillance methods tracking the success of elimination. Finally, analysis of all available O. volvulus mitochondrial genome data across Africa indicated the parasite meta-population fits an isolation-by-distance migration pattern, suggesting that transmission zones are large but with cross-continental migration unlikely.
title: Validierung des G-iHOT33 nach der COSMIN-Checklist und Evaluation der Lebensqualität mit Hüftbeschwerden
Creators: name: Weber, Johannes
name: Baumann, Florian
name: Zeman, Florian
name: Müller, Michael
name: Lahner, Matthias
name: Nerlich, Michael
name: Fickert, Stefan
Publisher: name: German Medical Science GMS Publishing House
Year: 2015
Subjects: subject: Lebensqualität
subject: Hüftgelenksbeschwerden
subject: Patient reported outcome (PRO)
subject: Validierung
subject: German International Hip Outcome Tool 33 (G-iHOT33)
subject: 610 Medical sciences; Medicine

description: Fragestellung: Patient-reported outcome (PRO) Messinstrumente haben eine zunehmend wichtige Rolle in der Ergebnisbewertung in Orthopädie und Unfallchirurgie. Etablierte Hüft-Scores sind vorwiegend auf die Evaluation der Alltagsfunktion mit Coxarthrose ausgelegt. Gerade bei jungen aktiven Patienten[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2015)
[B.7.06.] Gaston VIENS maire d’Orly, conseiller général du Val de Marne vous parle…
Creators: name: Diard, Jean
name: Bidou, Jacques (1945-....)
Publisher: name: École des Hautes Études en Sciences Sociales; Uni/Ci/Té
Year: 2023
Subjects: http://www.idref.fr/027463664/id
http://www.idref.fr/034705074/id
http://www.idref.fr/050613995/id
http://www.idref.fr/027261468/id

Abstract
Characterisation of RNA Binding Proteins TIA-1, TIAR and HuR Involved in Stress Granule Formation
Creators: name: SABOORA WARIS
Publisher: name: Monash University
Year: 2017
Subjects: Biochemistry
Molecular Biology

description: When cells are subjected to stress (such as heat, oxidative conditions, viral invasion) one of the ways they protect themselves is by forming cytoplasmic granules called stress granules (SG) where they store RNA. This thesis presents studies of the RNA/DNA binding proteins, TIA-1 (T-cell restricted intracellular antigen-1) and HuR (Human antigen R) that bind to and escort RNA to SG. I have investigated how these proteins move between compartments in cells and how they act together to bind the RNA. Overall, understanding of SG biology could facilitate the development of therapeutic intervention against pathological SG formation in neurodegenerative diseases.
Fortalecimiento de las competencias investigativas a partir de una estrategia mediada por el aprendizaje basado en Indagación (ABI) en la enseñanza de la introducción a la investigación social en los estudiantes del grado sexto de la Institución Educativa Mondeyal Isnos – Huila, periodo 2020 - 2021
Creators: name: Coral Ordoñez, Richard Alexander
Publisher: name: Universidad de Cartagena
Year: 2021
Subjects: subject: Tecnología educativa
subject: Innovaciones educativas
subject: Sitios web educativos
subject: Ciencias sociales - Enseñanza

description: La estructuración integral de los procesos pedagógicos relacionados con el fortalecimiento de las competencias investigativas entendidos sobre la premisa de formación de sujetos competentes tanto en el ámbito cognitivo, procedimental y actitudinal, asume mayor relevancia en el contexto educativo actual dado el impacto que estas implicaciones suponen en el mejoramiento en la calidad de los procesos de enseñanza - aprendizaje a fin de construir los cimientos que permiten al sujeto asumir de manera pertinente los retos que impone el mundo contemporáneo. En este sentido, el presente artículo recopila las implicaciones y los resultados alcanzados respecto al fortalecimiento de las competencias investigativas en el Área de Ciencias Sociales a partir de la implementación de una estrategia mediada por el Aprendizaje Basado en Indagación (ABI) y el uso eficiente de los recursos educativos digitales (RED) en estudiantes de primer grado de Básica Secundaria. Para ello se estructura un enfoque de investigación cualitativa bajo el modelo de Investigación Acción Participativa (IAP) efectuada mediante cuatro momentos; fase diagnóstica, fase de diseño, fase de implementación y fase de evaluación, en la que se emplearon técnicas e instrumentos de recolección como la observación participante, el grupo nominal, el cuestionario, el diario de campo, la lista de cotejo y la secuencia didáctica respectivamente. Consecuentemente; se presentan los resultados en los que se destaca la favorabilidad alcanzada en los procesos de fortalecimiento de las competencias investigativas (conceptualización, proposición, reflexión) donde se logra concluir sobre la incidencia sustancial en la transformación de las estructuras de aprendizaje de los participantes.
Estudio de factibilidad para el montaje de una empresa productora y comercializadora de un producto tipo snack a partir de mango, variedad “Magdalena River”
Creators: name: Montaño Satizabal, Harvey Samir
name: Montaño Satizabal, Linda Aurora
Publisher: name: Universidad de Cartagena
Year: 2015
Subjects: Estudio de mercado
Estudios de factibilidad
Estudio financiero

description: Tesis (Administrador Industrial).--Universidad de Cartagena. Facultad de Ciencias Económicas. Programa de Administración Industrial, 2015
description: El objetivo de esta investigación busca diseñar un estudio de factibilidad para la creación de una empresa productora y comercializadora de un producto tipo snack a partir de mango, variedad “Magdalena River” hacia el mercado de los Estados Unidos, y determinar la viabilidad financiera del proyecto mediante el diseño y análisis de estudios financieros a partir de variables VPN, TIR, flujo de caja y estados financieros.
How Do Assistance Dogs Help Their Handlers to Live Their Best Possible Lives?
Creators: name: Gravrok, Jennifer
Publisher: name: La Trobe
Year: 2023

description: Submission note: Submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Psychology and Public Health, College of Science, Health, and Engineering, La Trobe University, Victoria, Australia.

Thesis with publications.

Assistance dogs (AD) are highly trained to ameliorate effects of their handler’s specific disability, including physical, sensory, psychiatric, intellectual, or other mental disability. ADs are considered to provide numerous physical, psychological and social benefits to their handler that positively affect their life. However, they also present challenges, and are costly to train. Overall, these benefits and challenges remain poorly understood. This thesis aims to increase understanding of how AD’s assist their handlers to live their best possible life, focussing on the experiences of first-time handlers. The Thriving Through Relationships theory of social support is used to frame handlers’ perceptions of the support provided by ADs. The research employed a mixed-methods approach in order to attain a holistic understanding of handlers’ experiences. An initial questionnaire, informed by the Thriving Through Relationships theory, demonstrated that handlers did perceive that their AD assisted them to thrive. To determine more precisely how ADs achieve this outcome, eight longitudinal case studies were then undertaken, drawing on the experiences of first-time handlers and their care networks. The findings corroborated the benefits that have been reported previously and enhanced understanding of the prominent challenges. The information reported in this thesis will enable AD organizations to better prepare handlers for working with an AD and increase best practice initiatives in this emerging field.

This thesis was a recipient of the Nancy Millis Award for theses of exceptional merit.
title: Perinatalzentren.org: Ergebnisdaten von Krankenhäusern laienverständlich vermitteln
Creators: name: Erckenbrecht, Stefanie
name: Thomas, Teresa
name: Herrmann, Tobias
name: Konheiser, Stefanie
name: Heller, Günther
name: Broge, Björn
name: Szecsenyi, Joachim
Publisher: name: German Medical Science GMS Publishing House
Year: 2015
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Im Februar 2014 wurde die Webseite [link:https://www.perinatalzentren.org*https://www.perinatalzentren.org] erstmals veröffentlicht. Das Ziel dieser Seite ist es, die Versorgungsqualität von sehr kleinen Frühgeborenen unter 1.500 g in deutschen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 14. Deutscher Kongress für Versorgungsforschung
Thymus zetlandicus Ronniger & Druce
Creators: name: Bartolucci, Fabrizio
name: Walter, Johannes
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Lamiales
Lamiaceae
Thymus
Thymus zetlandicus

description: Thymus zetlandicus Ronniger & Druce in Druce (1925: 649)
 Type (lectotype, designated here):— UNITED KINGDOM. Shetland. Inseln, fitful Head, 1924, Druce G. C. s.n. (WRonniger 2008-0019864! upper specimen, isolectotypes W-Ronniger 2008-0019866!, W-Ronniger 2008-0019867!; image of the lectotype is available at http://herbarium.univie.ac.at/database/detail.php? ID =499535).
 Protologue citation:—“Scalloway; Fitful Head. As a forma nana with very small foliage, summit of Ranas Hill”.
 Taxonomic notes:— Thymus zetlandicus is a variant with densely haired leaves of Th. drucei Ronniger (see note on Th. britannicus).
description: Published as part of Bartolucci, Fabrizio & Walter, Johannes, 2015, Typification of names in the genus Thymus (Lamiaceae), pp. 137-147 in Phytotaxa 221 (2) on page 145, DOI: 10.11646/phytotaxa.221.2.3, http://zenodo.org/record/13633548
[B.7.07.] VIVRE MIEUX, Henri RAVERA vous parle…
Creators: name: Diard, Jean
name: Bidou, Jacques (1945-....)
Publisher: name: École des Hautes Études en Sciences Sociales; Uni/Ci/Té
Year: 2023
Subjects: http://www.idref.fr/050613995/id
http://www.idref.fr/027299031/id
http://www.idref.fr/027261468/id
http://www.idref.fr/034705074/id

Abstract
Modulation of the Psychological and Physiological Aspects of Pain
Creators: name: LINCOLN MARK TRACY
Publisher: name: Monash University
Year: 2017
Subjects: Neuroscience and Physiological Psychology

description: There is a complex, non-linear relationship between nociceptive input and pain experience. There are many psychological, physiological, and social factors that influence the experience of pain. The overarching aim of this thesis was to investigate the psychological and physiological aspects of pain experience, and determine whether these factors could be modulated by intranasal oxytocin administration. Several important conclusions can be drawn from the findings of this thesis, which contribute new insight into previously unanswered questions about the modulatory effects of intranasal oxytocin on autonomic regulation and pain experience.
Stress and Pregnancy: Consequences on Postnatal Maturation of the Kidney
Creators: name: DEBRA SUE YING FONG
Publisher: name: Monash University
Year: 2017
Subjects: subject: Physiology
subject: FOS: Biological sciences

description: Maternal stress during pregnancy can have adverse effects on the development of the fetus and can result in an increased risk of cardiovascular disease later in life. Our studies examined the underlying mechanisms and explore interventions that may prevent these adverse adaptations. We showed that maternal stress even for a short two-day period during pregnancy does not have favourable outcomes for the offspring, causing changes in renal development, which led to the ‘programming’ of hypertension during adulthood. Therefore, it is important to identify those at risk and to ascertain potential early therapeutic targets to prevent the progression to disease later on.
Literatura infantil para convivir”. Una estrategia didáctica para el fortalecimiento de la asertividad, en los estudiantes del grado tercero de básica primaria de la Institución Educativa Juan José Nieto sede Cibarco.
Creators: name: Pérez Miranda, Jhon Deivis
name: Luna Martínez, Xiomara Patricia
Publisher: name: Universidad de Cartagena
Year: 2017
Subjects: Literatura infantil
Textos de literatura infantil

description: Tesis (Licenciado en Educación Básica con Énfasis en Lengua Castellano) – Universidad de Cartagena en Convenio con la Universidad del Tolima. Facultad de Ciencias Sociales y Educación. Programa de Licenciatura en Educación Básica con Énfasis en Lengua Castellana, 2017
description: Literatura infantil para convivir es un proyecto investigativo que busca fortalecer en los niños y niñas de grado tercero de la institución Educativa Juan José Nieto, la asertividad, para reducir los niveles de violencia y mejorar la convivencia escolar.
title: Validierung des Proxy Alzheimer Disease Fragebogens (PAD) bei Angehörigen von Morbus Alzheimer-Patienten
Creators: name: Kreimendahl, Fabian
name: Becka, Denise
name: Huenges, Bert
name: Rychlik, Reinhard
name: Rusche, Herbert
Publisher: name: German Medical Science GMS Publishing House
Year: 2015
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Mehr als 1,3 Mio. Menschen in Deutschland sind von Demenzerkrankungen betroffen. Prognosen zufolge werden sich die Fallzahlen der Demenzerkrankung in der Gesellschaft in den Jahren bis 2050 nahezu verdoppeln. Bei dementiellen Erkrankungen handelt es sich um (neuro-)degenerative Erkrankungen,[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 14. Deutscher Kongress für Versorgungsforschung
Feb 11 Tuesday
Creators: name: Graves, Robert, 1895-1985
Publisher: name: University of Victoria Libraries
Year: 2021
Subjects: subject: Graves, Robert, 1895-1985
valueUri: http://id.worldcat.org/fast/31293
subject: Authors, English
valueUri: http://id.worldcat.org/fast/821945

description: Page from Robert Graves diary manuscript. The diary includes 1,546 pages with 117 enclosures: letters, clippings, photographs post cards, notes, games.
title: Transitionsversorgung von Mädchen und jungen Frauen mit einer seltenen genitalen Fehlbildung: Ergebnisse einer systematischen Literaturrecherche zu Versorgungsbedarfen der Zielgruppe
Creators: name: Wagner, Anke
name: Ueding, Esther
name: Baur, Marie-Christin
name: Pösch, Leonie
name: Hiltner, Hanna
name: Schäffeler, Norbert
name: Kronenthaler, Andrea
name: Rall, Katharina
name: Brucker, Sara
name: Simoes, Elisabeth
name: Rieger, Monika A.
Publisher: name: German Medical Science GMS Publishing House
Year: 2015
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Transitionsversorgung bezieht sich auf den Übergang von der Kinder- in die Erwachsenenmedizin. Dieser Übergang stellt bei seltenen Erkrankungen eine besondere Herausforderung dar. Zu diesen zählen auch genitale Fehlbildungen bei Frauen. Das häufigste Erscheinungsbild[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 14. Deutscher Kongress für Versorgungsforschung
Thermalization of noninteracting quantum systems coupled to blackbody radiation: A Lindblad-based analysis
Creators: name: Ostilli, Massimo
name: Presilla, Carlo
Publisher: name: arXiv
Year: 2016
Subjects: subject: Quantum Physics (quant-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We study the thermalization of an ensemble of $N$ elementary, arbitrarily-complex, quantum systems, mutually noninteracting but coupled as electric or magnetic dipoles to a blackbody radiation. The elementary systems can be all the same or belong to different species, distinguishable or indistinguishable, located at fixed positions or having translational degrees of freedom. Even if the energy spectra of the constituent systems are nondegenerate, as we suppose, the ensemble unavoidably presents degeneracies of the energy levels and/or of the energy gaps. We show that, due to these degeneracies, a thermalization analysis performed by the popular quantum optical master equation reveals a number of serious pathologies, possibly including a lack of ergodicity. On the other hand, a consistent thermalization scenario is obtained by introducing a Lindblad-based approach, in which the Lindblad operators, instead of being derived from a microscopic calculation, are established as the elements of an operatorial basis with squared amplitudes fixed by imposing a detailed balance condition and requiring their correspondence with the dipole transition rates evaluated under the first-order perturbation theory. Due to the above-mentioned degeneracies, this procedure suffers a basis arbitrariness which, however, can be removed by exploiting the fact that the thermalization of an ensemble of noninteracting systems cannot depend on the ensemble size. As a result, we provide a clear-cut partitioning of the thermalization time into dissipation and decoherence times, for which we derive formulas giving the dependence on the energy levels of the elementary systems, the size $N$ of the ensemble, and the temperature of the blackbody radiation.
description: 9 pages, 1 figure
title: Lipödem – Eine Herausforderung in der Versorgung?
Creators: name: Tobisch, Sandra
name: Schneider, Winfried
name: Reintjes, Ralf
name: Schönweiß, Katja
name: Kassen, Annette
Publisher: name: German Medical Science GMS Publishing House
Year: 2015
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Das Lipödem ist eine chronische progrediente Erkrankung, welche gehäuft bei Frauen auftrittv [ref:1]. Diese ist durch eine disproportionale Vermehrung des Unterhautfettgewebes der unteren Extremitäten und in wenigen Fällen der oberen Extremitäten charakterisiert[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 14. Deutscher Kongress für Versorgungsforschung
Educational Justice: A Multidimensional Account
Creators: name: Macfarlane, Kirsty
Publisher: name: La Trobe
Year: 2023

description: Submission note: A thesis submitted in total fulfillment of the requirements for the degree of Doctor of Philosophy to the Department of Politics, Media and Philosophy, School of Humanities and Social Sciences, College of Arts, Social Sciences and Commerce, La Trobe University, Victoria, Australia.

Achieving a fair or just distribution of education is widely considered important in modern liberal democratic societies. However, there is no consensus over the meaning of educational justice in the philosophical literature, and the concept is often used in ambiguous ways in public discourse and policy documents. This thesis aims to bring greater clarity to these discussions by developing a systematic and normatively compelling account of educational justice. In doing so, the thesis engages with the most prominent existing approaches in the literature, developing an original critique of egalitarian, prioritarian, sufficientarian and relational conceptions of educational justice. The thesis argues that although each of these theories has some appeal, none of them are satisfactory as standalone accounts of educational justice. The thesis also draws attention to a neglected value in current philosophical debate over educational justice, highlighting the role education can play in helping children develop their potentials. The thesis contends that this is a valuable aspect of education that deserves greater attention in the literature on educational justice, particularly because it draws attention to the fact that education can be valuable in ways that go beyond its role as a positional good. The thesis concludes by drawing on the preceding analysis to propose a multidimensional account of educational justice that incorporates a number of different principles, and develops a hierarchy to explain which principles should take priority in cases where they pull in different directions. The thesis argues that this multidimensional account of educational justice is normatively compelling and provides much greater clarity about what educational justice requires than any of the existing conceptions developed to date.
[B.7.11.] Gaston Viens, maire d’Orly, candidat du parti communiste français, votre Conseiller Général vous parle…
Creators: name: Diard, Jean
name: Bidou, Jacques (1945-....)
Publisher: name: École des Hautes Études en Sciences Sociales; Uni/Ci/Té
Year: 2023
Subjects: http://www.idref.fr/027261468/id
http://www.idref.fr/034705074/id
http://www.idref.fr/027681467/id
http://www.idref.fr/027299031/id
http://www.idref.fr/050613995/id

Abstract
New Insights Into Treating Ischemic Stroke
Creators: name: MEGAN ANNE EVANS
Publisher: name: Monash University
Year: 2017
Subjects: subject: 110201 Cardiology (incl. Cardiovascular Diseases)
subject: FOS: Clinical medicine
subject: Pharmacology
subject: Stem Cells
subject: Neuroscience

description: Stroke is a major cause of death and disability worldwide, and effective new treatment options are desperately needed. This thesis has assessed two new therapeutic options for their potential to improve outcome after a stroke. The candidate found that administration of amnion stem cells, which are placenta-derived stem cells, effectively reduced brain injury and improved long-term recovery of motor coordination after experimental stroke. In addition, she found that administration of vitamin D could also reduce the extent of stroke-induced brain damage. It is hoped that the findings may lead to the future use of these interventions to treat stroke patients.
[B.7.08.] LE PARTI COMMUNISTE FRANÇAIS s’adresse à vous. Elections présidentielles 1974
Creators: name: Diard, Jean
name: Bidou, Jacques (1945-....)
Publisher: name: École des Hautes Études en Sciences Sociales; Uni/Ci/Té
Year: 2023
Subjects: http://www.idref.fr/027299031/id
http://www.idref.fr/034705074/id
http://www.idref.fr/050613995/id
http://www.idref.fr/031054528/id
http://www.idref.fr/027261468/id

Abstract
Estudio fiscal y presupuestal del municipio de Margarita Bolívar 1985-1989
Creators: name: Angulo Izquierdo, Alberto
name: Ramos Hoyos, Freddy
Publisher: name: Universidad de Cartagena
Year: 1990
Subjects: Presupuesto municipal - Margarita - Bolívar - (1985 - 1989)
Impuesto - Margarita - Bolívar

description: Tesis (Economista).--Universidad de Cartagena. Facultad de Ciencias Económicas. Programa de Economía, 1990.
description: El presente trabajo tiene por objeto realizar un estudio fiscal y presupuestal del municipio de Margarita de Bolivar.
Identification and Characterisation of Human Adipocyte Precursor Cells
Creators: name: ARTHE RAAJENDIRAN
Publisher: name: Monash University
Year: 2017
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: 60104 Cell Metabolism
subject: Cell Biology
subject: 111601 Cell Physiology
subject: FOS: Basic medicine
subject: 60109 Proteomics and Intermolecular Interactions (excl. Medical Proteomics)

description: This study discovered that fat cells in the human body can be generated from three distinct populations of cells. These immature fat cells display anatomical and biological differences that are associated with divergent metabolic functions. The identification of these cells offers clues about the origin of metabolic disease.
[B.7.09.] Travailleurs, avec les communistes, vivre mieux, vivre libres
Creators: name: Diard, Jean
name: Bidou, Jacques (1945-....)
Publisher: name: École des Hautes Études en Sciences Sociales; Uni/Ci/Té
Year: 2023
Subjects: http://www.idref.fr/050613995/id
http://www.idref.fr/034705074/id
http://www.idref.fr/027261468/id

Abstract
title: 10-Jahres-Ergebnisse nach navigierter und konventioneller Knie-TEP-Implantation
Creators: name: Baier, Clemens
name: Maderbacher, Günther
name: Springorum, Hans-Robert
name: Wolfsteiner, Jochen
name: Grifka, Joachim
Publisher: name: German Medical Science GMS Publishing House
Year: 2015
Subjects: subject: 10-Jahres-Ergebnisse
subject: navigierte und konventioneller Knieendoprothetik im Vergleich
subject: 610 Medical sciences; Medicine

description: Fragestellung: Etwa 10 Jahre nach der routinemäßigen Einführung der Navigationstechnik in der Knieendoprothetik gibt es noch keine Belege für die Überlegenheit des neuen Verfahrens. Bisher konnte in mehreren großen Studien die Verbesserung der Implantatpositionierung[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2015)
Análisis de la influencia de la disminución de las partículas en suspensión del agua del Rio Magdalena, sobre la resistencia de mezclas de concreto de 3000 y 4000 PSI, en el municipio de Mompóx
Creators: name: Carmona Sanjuan, Carlos Andres
name: Puerta Vergara, Ana Elida
name: Barrios, Modesto (Asesor)
Publisher: name: Universidad de Cartagena
Year: 2011
Subjects: Vertimientos - Concreto 3000 y 4000 PSI
Agregados(Materiales de construcción)
Industria del comercio

description: Tesis (Ingeniero Civil).--Universidad de Cartagena. Facultad de Ciencias E Ingenierías. Programa de Ingeniería Civil, 2011.
description: El presente estudio tiene por objeto realizar un análisis comparativo técnico económico del valor del metro cubico de concreto entre disminuir la concentración de sólidos en suspensión y aumentar el contenido de cemento en las mezclas de 3000 y 4000 PSI con agua del Rio Magdalena en el municipio de Mompox.
Feb 10 Monday.
Creators: name: Graves, Robert, 1895-1985
Publisher: name: University of Victoria Libraries
Year: 2021
Subjects: subject: Authors, English
valueUri: http://id.worldcat.org/fast/821945
subject: Graves, Robert, 1895-1985
valueUri: http://id.worldcat.org/fast/31293

description: Page from Robert Graves diary manuscript. The diary includes 1,546 pages with 117 enclosures: letters, clippings, photographs post cards, notes, games.
Hot Weather and Worker Health in a Changing Climate
Creators: name: JUDITH ANNE MCINNES
Publisher: name: Monash University
Year: 2017
Subjects: Medicine

description: Work-related injuries exact a heavy toll. Studies have suggested that hot weather increases work-related injury risk. This is important because the climate is warming, and hot days, warm nights and heatwaves are expected to become more frequent and severe. This thesis investigated the relationship between hot weather and work-related injury for workers in Melbourne. The impact of daytime and overnight temperatures, as well as consecutive hot days and nights, were assessed. It found young workers, male workers and workers engaged in heavy work to be at increased risk of injury on hot days, while warm nights influenced risk of injury for female and older workers. Exposure to consecutive hot days also increased injury risk, with this effect becoming apparent at relatively moderate temperatures.
[B.7.10.a.] Une jeune mère, un militant catholique de Boulogne dialoguent avec Aimé Halbeher, candidat du Parti Communiste Français au conseil général
Creators: name: Diard, Jean
name: Bidou, Jacques (1945-....)
Publisher: name: École des Hautes Études en Sciences Sociales; Uni/Ci/Té
Year: 2023
Subjects: http://www.idref.fr/027681467/id
http://www.idref.fr/027299031/id
http://www.idref.fr/027261468/id
http://www.idref.fr/050613995/id
http://www.idref.fr/034705074/id

Abstract
Antigen Presentation during Influenza Virus Infection
Creators: name: TING WU
Publisher: name: Monash University
Year: 2017
Subjects: subject: Biochemistry
subject: Immunology
subject: FOS: Clinical medicine

description: T cell immunity to virus infection is driven by the recognition of antigenic viral peptide sequences presented on the surface of infected cells in complex with MHC molecules. Our understanding the factors that modulate the magnitude and efficacy of the immune response remain largely unknown. This thesis used powerful mass spectrometry-based techniques to probe and quantify the nature of antigen presentation following influenza virus infection, which was then related back to the anti-viral immune response. This work provides new insights into virus-host interactions and anti-viral immunity, the results of which will guide the development of therapeutics and peptide-based vaccines.
Employing QbD strategies to assess the impact of cell viability and density on the primary recovery of monoclonal antibodies
Creators: name: Wohlenberg, Ole Jacob
name: Kortmann, Carlotta
name: Meyer, Katharina V.
name: Scheper, Thomas
name: Solle, Dörte
Publisher: name: Weinheim : Wiley-VCH
Year: 2023
Subjects: subject: CHO
subject: DoE
subject: mAb
subject: PAT
subject: QbD
subject: Dewey Decimal Classification::600 | Technik::660 | Technische Chemie

description: Quality by Design (QbD) is one of the most important tools for the implementation of Process Analytical Technology (PAT) in biopharmaceutical production. For optimal characterization of a monoclonal antibody (mAb) upstream process a stepwise approach was implemented. The upstream was divided into three process stages, namely inoculum expansion, production, and primary recovery, which were investigated individually. This approach enables analysis of process parameters and associated intermediate quality attributes as well as systematic knowledge transfer to subsequent process steps. Following previous research, this study focuses on the primary recovery of the mAb and thereby marks the final step toward a holistic characterization of the upstream process. Based on gained knowledge during the production process evaluation, the cell viability and density were determined as critical parameters for the primary recovery. Directed cell viability adjustment was achieved using cytotoxic camptothecin in a novel protocol. Additionally, the cell separation method was added to the Design of Experiments (DoE) as a qualitative factor and varied between filtration and centrifugation. To assess the quality attributes after cell separation, the bioactivity of the mAb was analyzed using a cell-based assay and the purity of the supernatant was evaluated by measurement of process related impurities (host cell protein proportion, residual DNA). Multivariate data analysis of the compiled data confirmed the hypothesis that the upstream process has no significant influence on the bioactivity of the mAb. Therefore, process control must be tuned towards high mAb titers and purity after the primary recovery, enabling optimal downstream processing of the product. To minimize amounts of host cell proteins and residual DNA the cell viability should be maintained above 85% and the cell density should be controlled around 15 × 106 cells/ml during the cell removal. Thereby, this study shows the importance of QbD for the characterization of the primary recovery of mAbs and highlights the useful implementation of the stepwise approach over subsequent process stages.
title: Klinische und funktionelle Langzeitergebnisse nach Chopart-Luxationsfrakturen
Creators: name: Mißbach, Tobias
name: Schneiders, Wolfgang
name: Zwipp, Hans
name: Rammelt, Stefan
Publisher: name: German Medical Science GMS Publishing House
Year: 2015
Subjects: subject: Fuß
subject: Luxation
subject: Fraktur
subject: Chopart-Gelenk
subject: Funktion
subject: 610 Medical sciences; Medicine

description: Fragestellung: Chopart-Luxationsfrakturen sind seltene und oft übersehene Fußverletzungen, welche in der gegenwärtigen Literatur häufig unterrepräsentiert werden. Zielsetzung dieser retrospektiven Studie ist die Evaluation verschiedener patienten- und behandlungsspezifischer[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2015)
Level of Adherence and Associated Factors to Option B+ Pmtct Programme Among Pregnant & Lactating Mothers in Selected Government Health Facilities of South Wollo Zone, Amhara Region, North East Ethiopia, 2016
Creators: name: Tsegaye, Delelegn
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2016

description: Introduction፡ Adherence to ART among HIV positive pregnant & lactating mothers is a central component in PMTCT to reduce viral loads & achieve elimination of mother to child transmission of HIV. Option B+ PMTCT programme is a recently introduced approach to eliminate new HIV infection among children. This approach is based on treatment as prevention to mean starting lifelong ART for all HIV positive pregnant & lactating mothers without considering CD4 count or clinical stage of HIV/AIDS disease. Objectives: The aim of this study was to measure the level of adherence and identify factors associated with adherence to option B+ PMTCT programme among pregnant & lactating mothers in selected government health facilities of south wollo zone, Amhara region, north east Ethiopia Method: An institution based cross sectional quantitative study design was used. The study was conducted in two hospitals & five health centers found in south Wollo zone, Amhara region. The sample size required for this study was 191 HIV+ pregnant & lactating mothers who were on PMTCT follow up. The study subjects were taken consecutively until the sample size was met from March 1 to April 14, 2016. Standard structured data collection instrument was used & it was collected by using face to face interviewing. The data were entered in to EpiData 3.1 then exported to statistical package for social science (SPSS) window version 21 for analysis. Entered data were explored for errors & missing values then it was cleaned before analysis. Bivariate and multivariate logistic regression analyses were employed to identify associated factors for adherence. P-value less than 0.05 with 95 % confidence interval was used to state the association between independent predictors and the outcome variable. Result: A total of 190 HIV+ pregnant & lactating mothers were included in this study. The level of adherence on option B+ PMTCT drug was 87.9 %. Factors such as those who attend in Hospital(AOR 0.3,95% CI(0.11-0.82), rural residence (AOR 0.26, 95%CI (0.1-0.73) and those who faced challenges in the same day diagnosis of HIV and initiating lifelong option B+ treatment (AOR 0.08, 95%CI (0.02-0.37) were associated factors for adherence Conclusion & recommendation: mothers who attended for option B+ drugs in health centers, those who lived in urban area and who had no any challenges in same day diagnosing & initiating option B+ drugs were significantly associated factors for better adherence to option B+drugs. Therefore, the ability to effectively handle these factors is crucial in the success of option B+ programme. Key words: adherence, Option B+, HIV+ pregnant & lactating mothers, north east Ethiopia
Central neural control pathways directed to brown, white, and transformed "Beige" fat
Creators: name: NICOLE MAREE WIEDMANN
Publisher: name: Monash University
Year: 2017
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Neuroscience

description: The functional recruitment of brown and inducible “beige” fat is, primarily dependent on an intact sympathetic neural input, with little insight into the neural control of beige adipose tissue. Here we demonstrate that after induction of beige adipocytes in white fat after cold exposure there is a functional reorganisation of supraspinal pathways. Furthermore, the neurochemical profile of sympathetic ganglia projecting to beige fat becomes more alike the profile of those projecting to brown fat. The findings of this thesis significantly build upon our understanding of the neuroanatomical and neurochemical blueprint of pathways directed to brown, white, and transformed beige fat.
Quantitative Absorption Tomography Using Polychromatic X-rays
Creators: name: Eyou, Aileen Yowaresh Eyou
Publisher: name: La Trobe
Year: 2023

description: Submission note: A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the Department of Chemistry and Physics, La Trobe Molecular Sciences School, College of Science, Health and Engineering, La Trobe University, Victoria, Australia.

Thesis with publications.

X-ray computed tomography has been extensively used in many scientific and medical fields. High spatial resolution, high precision absorption x-ray tomography has been routinely conducted using monochromatized x-rays at synchrotron sources around the world. However, many practical applications of x-ray tomography have been carried out in small scale laboratories and medical clinics where the incident beams are polychromatic. Because interactions between an x-ray photon and matter depend on its energy, it is challenging to obtain quantitative results from a tomography measurement using polychromatic x-rays. One of the most significant sources of systematic error in absorption tomography using polychromatic x-rays is the well-known 'beam hardening' effect. As a polychromatic x-ray beam penetrates through an object, x-rays of lower energy are absorbed more strongly. This causes the spectrum of the x-ray beam to ‘shift’ toward the higher energy regime, resulting in an artificial reduction in the reconstructed density of the object. Overcoming this problem has attracted significant effort during the last decade or so. This work aims to develop a quantitative absorption tomography technique using polychromatic x-rays. The new technique takes into account the full spectral information of the incident polychromatic beam in the reconstruction process. The result is precise, quantitative, and free from the effects of beam hardening. Theoretical details and an experimental demonstration of the technique is described in determining the integrated column density of 2D objects and the density distribution of 3D objects. The results promise great opportunities for improving the capability of small-scale laboratories and medical clinics in conducting critical quantitative work.
[B.7.12.] Vérité, espoir
Creators: name: Diard, Jean
name: Bidou, Jacques (1945-....)
Publisher: name: École des Hautes Études en Sciences Sociales; Uni/Ci/Té
Year: 2023
Subjects: http://www.idref.fr/027299031/id
http://www.idref.fr/033140855/id
http://www.idref.fr/027261468/id
http://www.idref.fr/050613995/id
http://www.idref.fr/034705074/id

Abstract
Targeting the ribosome to treat advanced prostate cancer
Creators: name: RICHARD JOSEPH REBELLO
Publisher: name: Monash University
Year: 2017
Subjects: subject: 111201 Cancer Cell Biology
subject: FOS: Clinical medicine
subject: 111204 Cancer Therapy (excl. Chemotherapy and Radiation Therapy)

description: Metastatic castrate-resistant prostate cancer (mCRPC) remains incurable, highlighting the need for new therapeutic targets. Prostate epithelium is exquisitely sensitive to MYC activity and MYC is universally overexpressed in mCRPC. One key process in cancer cells is to accelerate growth via stimulation of high levels of ribosome biogenesis through regulation of RNA polymerase I (Pol I). This thesis describes preclinical evidence that co-targeting Pol I transcriptional activity and PIM kinases is an effective means of inhibiting MYC-driven prostate cancer. We employ numerous pre-clinical models of PC which shows the efficacy of therapies that combine to target MYC-directed signaling to the ribosome.
Feb 13 Thursday
Creators: name: Graves, Robert, 1895-1985
Publisher: name: University of Victoria Libraries
Year: 2021
Subjects: subject: Authors, English
valueUri: http://id.worldcat.org/fast/821945
subject: Graves, Robert, 1895-1985
valueUri: http://id.worldcat.org/fast/31293

description: Page from Robert Graves diary manuscript. The diary includes 1,546 pages with 117 enclosures: letters, clippings, photographs post cards, notes, games.
Power Distribution and Propulsion System for an All-Electric Short-Range Commuter Aircraft—A Case Study
Creators: name: Ebersberger, Janine
name: Fauth, Leon
name: Keuter, Ralf
name: Cao, Yongtao
name: Freund, Yannik
name: Hanke-Rauschenbach, Richard
name: Ponick, Bernd
name: Mertens, Axel
name: Friebe, Jens
Publisher: name: New York, NY : IEEE
Year: 2022
Subjects: subject: AEA
subject: aerospace electronics
subject: aircraft propulsion
subject: Aviation
subject: DC/DC converters
subject: electric power supply systems
subject: high voltage direct current
subject: power semiconductor devices
subject: reliability
subject: safety
subject: wide-bandgap semiconductors
subject: wiring harness
subject: Dewey Decimal Classification::600 | Technik::620 | Ingenieurwissenschaften und Maschinenbau::621 | Angewandte Physik::621,3 | Elektrotechnik, Elektronik
subject: Dewey Decimal Classification::000 | Allgemeines, Wissenschaft::000 | Informatik, Wissen, Systeme::004 | Informatik

description: To participate in the transition towards a sustainable use of energy, the aircraft sector needs to be transformed with respect to the energy carrier and propulsion methods. For smaller aircraft, a battery-electric approach is promising. While this will require extensive research and design together with the application of advanced components which are partly not available to this date, general design rules and key parameters and critical components can already be deduced. This publication presents the example design of the full propulsion system for a small commuter aircraft. This serves as a case study to highlight the influence of components and parameters on the overall efficiency and weight of the system. By that, future research can be directed towards the areas of high impact on the realization of all-electric aircraft. A optimization of several motor variants, inverter topologies and power supply grid parameters is performed. The weight of the fully electric propulsion system is dominated by the battery. Therefore, all subsequent components need to be designed towards a high efficiency in opposition to high power density.
title: Ergebnisse und Komplikationen nach Behandlung isolierter Ulna-Schaftfrakturen des Erwachsenen
Creators: name: Coulibaly, Marlon
name: Jones, Clifford
name: Sietsema, Debra
name: Hoffmann, Martin
name: Kruppa, Christiane
name: Schildhauer, Thomas A.
Publisher: name: German Medical Science GMS Publishing House
Year: 2015
Subjects: subject: Ulna
subject: Fraktur
subject: nicht-operative Therapie
subject: operative Therapie
subject: funktionelle Ergebnisse
subject: Komplikationen
subject: 610 Medical sciences; Medicine

description: Fragestellung: Isolierte Ulnaschaft-Frakturen (IUSF) des Erwachsenen sind selten Verletzungen und das Behandlungsregime wird weiterhin kontrovers diskutiert. Zielsetzung dieser Studie war die Analyse operativ und nicht-operativ behandelter Patienten mit einer IUSF. Methodik: Ueber einen 5-Jahres-Zeitraum[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2015)
[B.7.13.] 10 questions, 10 réponses
Creators: name: Diard, Jean
name: Bidou, Jacques (1945-....)
Publisher: name: École des Hautes Études en Sciences Sociales; Uni/Ci/Té
Year: 2023
Subjects: http://www.idref.fr/050613995/id
http://www.idref.fr/027299031/id
http://www.idref.fr/027261468/id
http://www.idref.fr/034705074/id
http://www.idref.fr/033140855/id

Abstract