cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Differential activation of nuclear inositide-dependent signalling pathways during erythropoiesis and myelopoiesis induced by lenalidomide and azacitidine in myelodysplastic syndromes (MDS)
Creators: name: Mongiorgi, Sara
name: Follo, Matilde Y.
name: Clissa, Cristina
name: Parisi, Sarah
name: Stanzani, Marta
name: Quaranta, Marilisa
name: Orsini, Ester
name: Martini, Desiree
name: Finelli, Carlo
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2015
Subjects: Nuclear Inositide Signalling; Erythroid Differentiation; Myeloid Differentiation

description: Inositide-dependent signalling pathways regulated by phosphoinositide-specific phospholi- pase C (PI-PLC) beta1 have been demonstrated to play important roles in MDS pathogenesis and in cell differentiation (1). Moreover, the MDS therapy aims at inducing myeloid and/or erythroid differentiation of MDS stem cells. Indeed, azacitidine is a demethylating agent that can induce myeloid differentiation. On the other hand, lenalidomide may restore a normal erythropoiesis. The exact molecular mechanisms underlying the effect of azacitidine and lenalidomide in MDS cells are still unclear, although it is clear that these therapies regulate stem cell proliferation, differentiation and apoptosis (2). The combination of azacitidine and lenalidomide in MDS therapy is now under considera- tion, given the capability of both drugs to balance proliferation and differentiation processes (3). In this study we analyzed the molecular effect of this combination therapy on PI-PLC isoenzymes, not only studying PI-PLCbeta1, but also PI-PLCgamma1, that can be associated with erythropoiesis. We analyzed 44 patients diagnosed with high-risk MDS who were given azacitidine and lenalidomide. Given the limited number of cells, we quantified the expression of these molecules by Real-Time PCR analyses and immunocytochemical experiments. Moreover, we carried out cell cycle analyses and studied both PI-PLCbeta1 methylation status and the expression of Globin genes. In our case series, 28/44 patients were evaluable, with an overall response rate of 78.6% (22/28 cases). At a molecular level, a significant increase of PI-PLCbeta1 and/or PI-PLCgamma1 expression was associated with a favourable clinical response to the combination therapy. Responder cases also showed an increase of Beta-globin expression, hinting at a specific contri- bution of lenalidomide on erythroid activation, whilst the frequent demethylation of PI-PLCbeta1 promoter could be specifically linked to azacitidine. Taken together, our results show that the combination of azacitidine and lenalidomide can be important for activating PI-PLC isoenzymes, therefore regulating myeloid and erythroid dif- ferentiation in MDS cells.
description: Italian Journal of Anatomy and Embryology, Vol. 120, No. 1 (Supplement) 2015
Electron transport across electrically switchable magnetic molecules
Creators: name: Shukla, Sujeet K.
name: Sanvito, Stefano
Publisher: name: arXiv
Year: 2009
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We investigate the electron transport properties of a model magnetic molecule formed by two magnetic centers whose exchange coupling can be altered with a longitudinal electric field. In general we find a negative differential conductance at low temperatures originating from the different scattering amplitudes of the singlet and triplet states. More interestingly, when the molecule is strongly coupled to the leads and the potential drop at the magnetic centers is only weakly dependent on the magnetic configuration, we find that there is a critical voltage V_C at which the current becomes independent of the temperature. This corresponds to a peak in the low temperature current noise. In such limit we demonstrate that the quadratic current fluctuations are proportional to the product between the conductance fluctuations and the temperature.
title: ÐÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÐµÐ¿ÑÐµÐ·ÐµÐ½ÑÐ°ÑÐ¸Ð²Ð½Ð¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ Ð² Ð¿ÑÐµÐ¿Ð¾Ð´Ð°Ð²Ð°Ð½Ð¸Ð¸ Ð°Ð½Ð³Ð»Ð¸Ð¹ÑÐºÐ¾Ð³Ð¾ ÑÐ·ÑÐºÐ°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
Creators: name: Ð§Ð°ÑÑÐ¾ÑÑÑÐ¿Ð¾Ð²Ð°, ÐÐ»ÐµÐºÑÐ°Ð½Ð´ÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2018
Subjects: Ð¼ÐµÑÐ¾Ð´Ð¸ÐºÐ° Ð¿ÑÐµÐ¿Ð¾Ð´Ð°Ð²Ð°Ð½Ð¸Ñ Ð¸Ð½Ð¾ÑÑÑÐ°Ð½Ð½Ð¾Ð³Ð¾ ÑÐ·ÑÐºÐ°
ÑÐµÐ¿ÑÐµÐ·ÐµÐ½ÑÐ°ÑÐ¸Ð²Ð½Ð°Ñ ÑÐ¸ÑÑÐµÐ¼Ð° ÑÐµÐ»Ð¾Ð²ÐµÐºÐ°
ÑÐ¸Ð¿Ñ Ð²Ð¾ÑÐ¿ÑÐ¸ÑÑÐ¸Ñ
ÑÑÑÐ°ÑÐµÐ³Ð¸Ð¸ Ð¾Ð±ÑÑÐµÐ½Ð¸Ñ
ÑÐ¾ÑÐ¼Ð¸ÑÑÑÑÐ¸Ð¹ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½Ñ
Ð¼Ð¾ÑÐ¸Ð²Ð°ÑÐ¸Ñ

description: Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ ÑÐ°ÑÐºÑÑÐ²Ð°ÑÑÑÑ ÑÐ°ÐºÐ¸Ðµ Ð¿Ð¾Ð½ÑÑÐ¸Ñ ÐºÐ°Ðº ÑÐµÐ¿ÑÐµÐ·ÐµÐ½ÑÐ°ÑÐ¸Ð²Ð½Ð°Ñ ÑÐ¸ÑÑÐµÐ¼Ð° ÑÐµÐ»Ð¾Ð²ÐµÐºÐ° Ð¸ ÐµÐµ Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸ Ñ ÑÐ¾ÑÐºÐ¸ Ð·ÑÐµÐ½Ð¸Ñ Ð¿ÑÐµÐ¿Ð¾Ð´Ð°Ð²Ð°Ð½Ð¸Ñ Ð¸Ð½Ð¾ÑÑÑÐ°Ð½Ð½Ð¾Ð³Ð¾ ÑÐ·ÑÐºÐ°, Ð²Ð¾ÑÐ¿ÑÐ¸ÑÑÐ¸Ðµ Ð¸ ÐµÐ³Ð¾ Ð³Ð»Ð°Ð²Ð½ÑÐµ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸ÐºÐ¸. Ð¢Ð°ÐºÐ¶Ðµ Ð² Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¸ Ð¾Ð¿Ð¸ÑÑÐ²Ð°ÐµÑÑÑ Ð²Ð·Ð°Ð¸Ð¼Ð¾ÑÐ²ÑÐ·Ñ Ð¼ÐµÐ¶Ð´Ñ ÑÐ¸Ð¿Ð°Ð¼Ð¸ Ð²Ð¾ÑÐ¿ÑÐ¸ÑÑÐ¸Ñ, ÑÑÐ¿ÐµÐ²Ð°ÐµÐ¼Ð¾ÑÑÑÑ Ð¸ Ð¼Ð¾ÑÐ¸Ð²Ð°ÑÐ¸ÐµÐ¹ ÑÑÑÐ´ÐµÐ½ÑÐ¾Ð². Ð Ð¿ÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÐ°ÑÑÐ¸ ÑÐ°Ð±Ð¾ÑÑ Ð¾Ð¿Ð¸ÑÐ°Ð½ ÑÐ¾ÑÐ¼Ð¸ÑÑÑÑÐ¸Ð¹ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½Ñ, Ð° ÑÐ°ÐºÐ¶Ðµ Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ñ Ð°Ð½Ð°Ð»Ð¸Ð·Ñ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ Ð² ÑÐ¾Ð´Ðµ ÑÐ°Ð±Ð¾ÑÑ Ð´Ð°Ð½Ð½ÑÑ.
Quel simil-Saturno è un vero terremoto
Creators: Stefano Parisini
Publisher: name: Media Inaf
Year: 2019

È grande come il nostro pianeta con gli anelli, ma molto più caldo. È il primo esopianeta scoperto grazie all’analisi delle onde sismiche stellari rilevate nei dati raccolti dalla missione Tess della Nasa
title: ÐÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ñ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²ÐµÐ½Ð½Ð¾-Ñ Ð¾Ð·ÑÐ¹ÑÑÐ²ÐµÐ½Ð½Ð¾Ð¹ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ ÐºÑÐ»Ð¸Ð½Ð°ÑÐ½Ð¾Ð³Ð¾ ÑÐµÑ Ð° Ð¿Ð¾ Ð²ÑÐ¿ÑÑÐºÑ ÑÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ¾Ð²Ð°Ð½Ð½ÑÑ Ð¾Ð±ÐµÐ´Ð¾Ð² Ð¼Ð¾ÑÐ½Ð¾ÑÑÑÑ 1,5 ÑÐ¾Ð½Ð½Ñ Ð² ÑÑÑÐºÐ¸ Ð´Ð»Ñ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¿Ð¸ÑÐ°Ð½Ð¸Ñ Ð½Ð° ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÐ½ÑÑ Ð¿Ð»Ð¾ÑÐ°Ð´ÐºÐ°Ñ Ð³. Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³Ð°
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: ÐÑÑÑÐº, ÐÐ¸ÐºÐ¸ÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: ÐºÑÐ»Ð¸Ð½Ð°ÑÐ½ÑÐ¹ ÑÐµÑ
Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²ÐµÐ½Ð½Ð¾-ÑÐ¾ÑÐ³Ð¾Ð²Ð°Ñ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÑ
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Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²ÐµÐ½Ð½Ð°Ñ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð°

description: ÐÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð¾ Ð¼Ð°ÑÐºÐµÑÐ¸Ð½Ð³Ð¾Ð²Ð¾Ðµ Ð¾Ð±Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð½ÐµÐ¾Ð±ÑÐ¾Ð´Ð¸Ð¼Ð¾ÑÑÐ¸ Ð¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÐºÑÐ»Ð¸Ð½Ð°ÑÐ½Ð¾Ð³Ð¾ ÑÐµÑÐ°, Ð¿ÑÐ¾Ð¸Ð·Ð²ÐµÐ´ÐµÐ½Ñ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ðµ ÑÐ°ÑÑÐµÑÑ Ð¾Ð±Ð¾ÑÑÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ, Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð° Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÑÑÑÐºÑÑÑÐ° Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ. Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ñ Ð¼ÐµÑÐ¾Ð¿ÑÐ¸ÑÑÐ¸Ñ Ð¿Ð¾ Ð¾Ð±ÐµÑÐ¿ÐµÑÐµÐ½Ð¸Ñ Ð±ÐµÐ·Ð¾Ð¿Ð°ÑÐ½Ð¾ÑÑÐ¸ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ Ð¿ÑÐ¾ÐµÐºÑÐ¸ÑÑÐµÐ¼Ð¾Ð³Ð¾ Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ, ÐµÐ³Ð¾ Ð¿Ð»Ð°Ð½Ð¸ÑÐ¾Ð²Ð¾ÑÐ½Ð¾Ðµ ÑÐµÑÐµÐ½Ð¸Ðµ Ð¸ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ñ Ð¾ÑÐ½Ð¾Ð²Ð½ÑÐµ ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»Ð¸.
Experiences of trainee clinical psychologists and workplace supervisors when mental health difficulties are shared
Creators: name: Hannah, Serena
Publisher: name: Lancaster University
Year: 2024

description: This thesis consists of three papers including a literature review,
 research paper and a critical appraisal. The systematic literature review
 focuses on the experiences of workplace supervisors and managers when
 managing employees with mental health difficulties. A thematic synthesis
 was undertaken on 19 papers. Four themes were developed which highlighted
 the influence of supervisors’ perceptions of mental health difficulties
 and of their role in the provision of support, the need for supervisors to
 have access to support and advice to provide effective support to
 employees, the influence of understanding of mental health difficulties
 and the barriers to understanding, and the emotional challenges and
 rewards of supporting employees with mental health difficulties.
 Recommendations are made for supervisors and organisations regarding the
 support needs of supervisors when managing employees with mental health
 difficulties.

 The research paper explores the experiences of trainee clinical
 psychologists when sharing their mental health difficulties with tutors
 and supervisors during training. Thematic analysis was utilised to explore
 the experiences of 12 participants. Four themes were developed; namely,
 weighing up whether to share; creating safety to share and feeling
 supported; dilemmas, feeling vulnerable and powerless to challenge
 perceptions; and experience shaping their practice and identity.
 Recommendations are made for supervisors, tutors and training programmes
 regarding creating safe supportive environments to support trainees to
 share their mental health difficulties.

 The critical appraisal chapter reviews the findings of these two papers
 alongside a discussion of epistemological influences and methodological
 decisions taken during these projects and some of the challenges of
 undertaking research in this area.
Gara di velocità sul bordo del Sole
Creators: Maura Sandri
Publisher: name: Media Inaf
Year: 2019

Un team di astrofisici ha riscontrato che, nelle correnti di un brillamento solare, gli ioni di stronzio si muovono il 22 per cento più velocemente degli atomi di sodio. I risultati dello studio sono stati pubblicati su The Astrophysical Journal
Fermat's spiral and the line between Yin and Yang
Creators: name: Banakh, Taras
name: Verbitsky, Oleg
name: Vorobets, Yaroslav
Publisher: name: arXiv
Year: 2009
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: Let $D$ denote a disk of unit area. We call a subset $A$ of $D$ perfect if it has measure 1/2 and, with respect to any axial symmetry of $D$, the maximal symmetric subset of $A$ has measure 1/4. We call a curve $β$ in $D$ an yin-yang line if $β$ splits $D$ into two congruent perfect sets, $β$ crosses each concentric circle of $D$ twice, $β$ crosses each radius of $D$ once. We prove that Fermat's spiral is a unique yin-yang line in the class of smooth curves algebraic in polar coordinates.
description: 20 pages, 7 figures. In the 2nd version, a minor correction is made
A Mesoamerican Urban Road Network: An Analysis of Pedestrian Pathways of Angamuco, Michoacán
Creators: name: Solinis-Casparius, Rodrigo
Publisher: name: University of Illinois at Chicago
Year: 2023
Subjects: Archaeology

description: This article examines the urban layout and development of the ancient city of Angamuco (AD 250-1530) - a populated urban center located within the core area of the Purépecha Empire in Michoacán, Mexico - through the lens of its complex road network. Image and network analysis of lidar datasets revealed more than 3,000 roads distributed throughout the site, identified the main patterns of road arrangement, and documented variable accessibility within the city. After presenting a summary of these results, I propose that road networks are fundamental components of urban centers that can help reveal social configurations, local interactions, and models of governance. The study of the road network at the site of Angamuco suggests that this city developed organically without the strong influence of political hierarchy a few centuries prior to the formation of the Purépecha Empire. Angamuco inhabitants organized and negotiated space and settlement within their immediate community and had access to virtually all areas of the city.
Sopravvissuti all’esterno della Stazione spaziale
Creators: Paolo Soletta
Publisher: name: Media Inaf
Year: 2019

Dal 2014 al 2016 centinaia di campioni di organismi sono stati esposti alle condizioni che si possono incontrare su Marte, o in generale nello spazio, mentre erano a bordo della Stazione spaziale internazionale. I risultati del progetto vengono presentati oggi a Berlino
Developmental aspects of the adipose tissue. From fetal to adult humans
Creators: name: Frontini, Andrea
name: Sartini, Loris
name: Banita, Monica
name: Pisoschi, Catalina
name: Fusaru, Marina
name: Zingaretti, Cristina
name: Giordano, Antonio
name: Cinti, Saverio
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2015
Subjects: Brown adipose tissue; White adipose tissue; development; morphology; immunohistochemistry

description: Brown and white adipocytes are found together at discrete anatomical locations; the multilocular UCP1-positive adipocytes that are interspersed among white adi- pocytes are also known as brite or beige adipocytes (1). Brown adipose tissue (BAT) undergoes a significant reduction in the course of human life. This study aims to characterize developmental patterns of BAT and white AT in specific anatomical locations by comparing fetal and adult human fat depots. Several depots of the subcutaneous and visceral compartments were evaluated in 12 subjects during fetal development (from 16 up to 39 weeks) using immunohistology, morphometry and TEM. Comparison with the corresponding fat depot found in adults was then performed. Fat tissue was first detected in the vasculo-adipocytic anlages in the upper portion of the subcutaneous area. In particular, the cervical depot had a layered structure where the vast majority of adipocytes in deep as well as superficial layers had a clear multilocular UCP1-positive aspects. Adrenergic fibers appear in the fat anlages only in the final stage of development and after UCP1 protein expression. Zic1 (brown) and Hoxc8 (white/brite) adipocytes markers have been tested in different depots and at different time points of development (2). Findings suggest that phenotypic conver- sion and/or other mechanisms may drive the “whitening” of some depots, leading to BAT disappearance in adult humans. Uncovering the mechanisms involved in brown/brite adipocyte recruitment and maintenance in adult humans would have the potential to inspire therapeutic strategies that increase energy expenditure and to curb obesity and metabolic diseases.
description: Italian Journal of Anatomy and Embryology, Vol. 120, No. 1 (Supplement) 2015
Next-to-Leading Order QCD Corrections to Heavy Quark Correlations in Longitudinally Polarized Hadron-Hadron Collisions
Creators: name: Riedl, Johann
name: Schafer, Andreas
name: Stratmann, Marco
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present a comprehensive phenomenological study of heavy flavor distributions and correlations in longitudinally polarized proton-proton collisions at BNL-RHIC. All results are obtained with a flexible parton-level Monte Carlo program at next-to-leading order accuracy and include the fragmentation into heavy mesons, their subsequent semi-leptonic decays, and experimental cuts. Next-to-leading order QCD corrections are found to be significant for both cross sections and double-spin asymmetries. The sensitivity of heavy flavor measurements at BNL-RHIC to the gluon polarization of the nucleon is assessed. Electron-muon and muon-muon correlations turn out to be the most promising observables. Theoretical uncertainties are estimated by varying renormalization and factorization scales, heavy quark masses, and fragmentation parameters.
description: 21 pages, 18 figures
Reprogramming of human keratinocytes into functional cardiomyocytes
Creators: name: Ghinassi, Barbara
name: D’Amico, Maria
name: Izzicupo, Pascal
name: Di Baldassarre, Angela
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2015

description: Purpose. Induced pluripotent stem cells (iPS) can be generated by patients intro- ducing transcription factors that are highly expressed in embryonic stem (ES) cells into somatic cells. However, the various iPS cell lines are characterized by different properties such as differentiation efficiency and potential safety hazards. Among several readily available primary human somatic cell types, keratinocytes can be isolated easily from human skin or hair follicle, and therefore represent an attractive cell source for reprogramming. The aims of the present study were: 1. To assess the cardiomyogenic potential of human keratynocytes-derived iPS. 2. To increase the differentiation efficiency in order to obtain a homogeneous population of beating cardiomyocytes, also overcoming the limitation of embryonic body formation.
Methods. Established iPS cell line obtained from human keratinocytes was cultured in monolayer and exposed sequentially to Ascorbic Acid, 5-Azacytidine, BMP4, ActivinA, VEGF up to 20 days. Differentiation was evaluated monitoring the expression of Nkx2.5, Gata4, sarcomeric α-actinin, α cardiac myosin heavy chain, cardiac T-troponin and Connexin43 and β-adrenoceptors as cardiac markers, by Western Blot, immunofluorescent and cytometric analyses. An ImageStream analysis for a simulta- neous quantitative and morphological evaluation was also performed.
Results. During the differentiation induction, iPS became positive to all the analyzed cardiac markers. In particular, we observed a rapid and significant increase of Nkx2.5 and Gata4 expression (14.7±0.7% vs 43.2±2.1% Nkx2.5+ and 21.7±1.2 vs 65.9±3.6% Gata4+ in iPS and 15 days after the induction respectively, p<.005, analy- sis by ImageStream), with a significant nuclear translocation (nuclear+ cells:7.2±0.8% vs 18.8±2.1% of the Nkx2.5+ cells in iPS and 15 days after the induction respectively, p<.005, analysis by ImageStream). The differentiation process was accompanied by a modulation of β1- and β2-adrenoceptors expression. Foci of spontaneous contraction were observed after only 5 days from the induction and after 15 days the beating cells represented about the 60-90% of the entire population. Moreover, differentiated cardio- myocytes responded to adrenergic stimulation by increasing the contraction rate. Conclusion. iPS obtained from hKeratinocytes efficiently differentiate into cardi- omyocytes giving rise to a homogenous population with cardiac-specific molecular and functional properties.
description: Italian Journal of Anatomy and Embryology, Vol. 120, No. 1 (Supplement) 2015
Giochiamo che io ero un’astronoma?
Creators: Stefano Sandrelli
Publisher: name: Media Inaf
Year: 2019

Nel primo fine settimana di aprile, a Modena, l’Istituto nazionale di astrofisica si mette in gioco. Dalla caccia al radiotesoro alla colonizzazione di mondi alieni, ecco tutte le proposte astronomiche in programma a Play, il Festival del gioco
Circulating endothelial progenitor cells from patients with renal cell carcinoma display aberrant VEGF regulation, reduced apoptosis and altered ultrastructure
Creators: name: Guerra, Germano
name: Poletto, Valentina
name: Biggiogera, Marco
name: Dragoni, Silvia
name: Lim, Dmitry
name: Porta, Camillo
name: Montagnani, Stefania
name: Tafuri, Domenico
name: Rosti, Vittorio
name: Moccia, Francesco
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2015
Subjects: Renal carcinoma; VEGF; Endothelial Progenitor Cells (EPCs); Ca 2+ machinery

description: Endothelial colony forming cells (ECFCs) are the only endothelial progenitor cells (EPCs) subtype belonging to the endothelial phenotype and capable of forming neovessels in vivo. We have recently shown that the intracellular Ca2+ machinery plays a key role in ECFC activation and is remodeled in ECFCs isolated from patients suffering from renal cellular carcinoma (RCC-ECFCs). More specifically, ECFCs upregulate the store-operated Ca2+ entry (SOCE) machinery, while they seemingly show a reduction in the Ca2+ concentration within the endoplasmic reticulum ([Ca2+]ER). Metastatic RCC patients are commonly treated with an anti-vascular endothelial growth factor (VEGF) therapy, but they show either intrinsic or adaptive refractoriness, which ultimately leads to their death. Herein, we assessed whether and how the rearrangement of the Ca2+ machinery impacts on the pro-angiogenic Ca2+ response to VEGF, which stimulates normal ECFCs (N-ECFCs) through an oscillatory Ca2+ response. We found that VEGF stimulates the nuclear translocation of p65/RelA, a major component of the Ca2+-dependent transcription fac- tor NF-kB, in N-ECFCs. This process is blocked by the pharmacological abrogation of VEGF-induced Ca2+ oscillations. We further showed that NF-kB controls VEGF-induced protein expression of E-selectin, VCAM-1 and MMP9. Likewise, VEGF-induced expression was also inhibited by the pharmacological suppression of the accompanying Ca2+ spikes. Thus, VEGF induces a Ca2+-dependent, NF-kB-mediated protein expression in N-ECFCs. VEGF did not trigger protein expression in RCC-ECFCs despite the fact that VEGFR-2 was normally expressed and auto-phosphorylated. Our subsequent studies employed the tar- geted recombinant Ca2+-sensitive photoprotein aequorin to confirm that [Ca2+]ER is lower in RCC-ECFCs; surprisingly, electron microscopy analysis revealed that the endoplasmic reticulum cisternae are enlarged rather than shrinked in these cells. These results show for the first time that VEGF fails to stimulate tumor-derived ECFCs: these findings could therefore help to understand the relative failure of anti-VEGF treatment in RCC patients. References
description: Italian Journal of Anatomy and Embryology, Vol. 120, No. 1 (Supplement) 2015
title: ÐÐµÐ¶ÑÑÐ½Ð¸ÑÐµÑÐºÐ¸Ðµ ÐºÐ¾Ð½ÑÐ»Ð¸ÐºÑÑ Ð² ÑÐ¾Ð²ÑÐµÐ¼ÐµÐ½Ð½Ð¾Ð¹ Ð Ð¾ÑÑÐ¸Ð¸ (Ð½Ð° Ð¿ÑÐ¸Ð¼ÐµÑÐµ Ð¡ÐµÐ²ÐµÑÐ½Ð¾Ð³Ð¾ ÐÐ°Ð²ÐºÐ°Ð·Ð°)
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ¸ ÐÑÑ Ð°Ð¾
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2018
Subjects: Ð¼ÐµÐ¶ÑÑÐ½Ð¸ÑÐµÑÐºÐ¸Ðµ ÐºÐ¾Ð½ÑÐ»Ð¸ÐºÑÑ
Ð Ð¾ÑÑÐ¸Ñ
Ð¡ÐµÐ²ÐµÑÐ½ÑÐ¹ ÐÐ°Ð²ÐºÐ°Ð·
ÑÑÐ½Ð¸ÑÐµÑÐºÐ¸Ðµ ÐºÐ¾Ð½ÑÐ»Ð¸ÐºÑÑ

description: Ð XXI Ð²ÐµÐºÐµ ÑÑÐ½Ð¸ÑÐµÑÐºÐ¸Ðµ ÐºÐ¾Ð½ÑÐ»Ð¸ÐºÑÑ Ð² Ð·Ð½Ð°ÑÐ¸ÑÐµÐ»ÑÐ½Ð¾Ð¹ ÑÑÐµÐ¿ÐµÐ½Ð¸ Ð¿Ð¾Ð²Ð»Ð¸ÑÐ»Ð¸ Ð½Ð° Ð¿ÑÐ¾ÑÐ²ÐµÑÐ°Ð½Ð¸Ðµ Ð¸ ÑÑÐ°Ð±Ð¸Ð»ÑÐ½Ð¾ÑÑÑ Ð Ð¾ÑÑÐ¸Ð¸. Ð¡ÐµÐ²ÐµÑÐ½ÑÐ¹ ÐÐ°Ð²ÐºÐ°Ð· ÑÐ²Ð»ÑÐµÑÑÑ ÑÐ°Ð¼ÑÐ¼ Ð½ÐµÑÑÑÐ¾Ð¹ÑÐ¸Ð²ÑÐ¼ ÑÐµÐ³Ð¸Ð¾Ð½Ð¾Ð¼ ÑÑÑÐ°Ð½Ñ. Ð­ÑÐ¾ ÑÐµÐ³Ð¸Ð¾Ð½ ÑÑÐ½Ð¾Ð¿Ð¾Ð»Ð¸ÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¸ ÑÐµÑÑÐ¸ÑÐ¾ÑÐ¸Ð°Ð»ÑÐ½ÑÑ ÐºÐ¾Ð½ÑÐ»Ð¸ÐºÑÐ¾Ð², ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¸Ñ ÐºÑÐ¸Ð·Ð¸ÑÐ¾Ð², ÑÐ¾ÑÐ¸Ð°Ð»ÑÐ½Ð¾Ð¹ ÑÑÑÐ±ÑÐ»ÐµÐ½ÑÐ½Ð¾ÑÑÐ¸. Ð ÑÐ°Ð±Ð¾ÑÐµ Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÑÑÑÑÑ ÑÑÐ½Ð¸ÑÐµÑÐºÐ¸Ðµ ÐºÐ¾Ð½ÑÐ»Ð¸ÐºÑÑ Ñ ÑÐ°Ð·Ð½ÑÑ ÑÑÐ¾ÑÐ¾Ð½ Ð¸ ÑÐ°ÑÑÐ¼Ð°ÑÑÐ¸Ð²Ð°ÑÑÑÑ Ð¿ÑÐ¸ÑÐ¸Ð½Ñ ÑÑÐ½Ð¸ÑÐµÑÐºÐ¸Ñ ÐºÐ¾Ð½ÑÐ»Ð¸ÐºÑÐ¾Ð².
A ring collection spectrometer investigation of the decay of Sb 125
Creators: name: Payne, Frank Alden
Publisher: name: University of British Columbia
Year: 2011

description: A thin-lens beta-ray spectrometer has been modified for collection of beta-rays at the position of the ring focus. This has increased the gathering power/line width ratio from ∽ 0.12 to ∽0.8. The focusing properties of the instrument have been investigated for various geometries. Using the modified spectrometer, the decay scheme of Sb 125 - Te 125 has been investigated. The primary beta spectrum, photoelectron spectra and beta-gamma coincidence spectra have been measured. From conversion coefficient measurements, the following radiative transition multipolarities were determined (energies in kev): 176(E2+M1), 428(E2+M1), 464(E2), 602(E2+M1) and 638(E2). Five primary beta groups have been identified with end point energies of 626, 450, 307, 246 and 133 kev. Previously unobserved transitions of 76, 143, 219, 355, 540 and 640 kev have been identified. Based on all experimental evidence the following states of Te 125 with spin and parity assignments have been proposed: ground state (S1/2+), 36 kev (d₃/2+), 145 kev (h₁₁/₂-), 321 kev (9/2-), 464 kev (5/2+), 525 kev (11/2- or 9/2-), 540 kev (11/2- or 9/2-), 638 kev (5/2+) and 676 kev (spin and parity undetermined).
Analysis of large-scale anisotropy of ultra-high energy cosmic rays in HiRes data
Creators: name: Abbasi, R. U.
name: Abu-Zayyad, T.
name: Allen, M.
name: Amann, J. F.
name: Archbold, G.
name: Belov, K.
name: Belz, J. W.
name: Bergman, D. R.
name: Blake, S. A.
name: Brusova, O. A.
name: Burt, G. W.
name: Cannon, C.
name: Cao, Z.
name: Deng, W.
name: Fedorova, Y.
name: Findlay, J.
name: Finley, C. B.
name: Gray, R. C.
name: Hanlon, W. F.
name: Hoffman, C. M.
name: Holzscheiter, M. H.
name: Hughes, G.
name: Hüntemeyer, P.
name: Ivanov, D.
name: Jones, B. F
name: Jui, C. C. H.
name: Kim, K.
name: Kirn, M. A.
name: Koers, H.
name: Loh, E. C.
name: Maestas, M. M.
name: Manago, N.
name: Marek, L. J.
name: Martens, K.
name: Matthews, J. A. J.
name: Matthews, J. N.
name: Moore, S. A.
name: O'Neill, A.
name: Painter, C. A.
name: Perera, L.
name: Reil, K.
name: Riehle, R.
name: Roberts, M. D.
name: Rodriguez, D.
name: Sasaki, M.
name: Schnetzer, S. R.
name: Scott, L. M.
name: Sinnis, G.
name: Smith, J. D.
name: Sokolsky, P.
name: Song, C.
name: Springer, R. W.
name: Stokes, B. T.
name: Stratton, S. R.
name: Thomas, J. R.
name: Thomas, S. B.
name: Thomson, G. B.
name: Tinyakov, P.
name: Tupa, D.
name: Wiencke, L. R.
name: Zech, A.
name: Zhang, X.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Stereo data collected by the HiRes experiment over a six year period are examined for large-scale anisotropy related to the inhomogeneous distribution of matter in the nearby Universe. We consider the generic case of small cosmic-ray deflections and a large number of sources tracing the matter distribution. In this matter tracer model the expected cosmic ray flux depends essentially on a single free parameter, the typical deflection angle theta. We find that the HiRes data with threshold energies of 40 EeV and 57 EeV are incompatible with the matter tracer model at a 95% confidence level unless theta is larger than 10 degrees and are compatible with an isotropic flux. The data set above 10 EeV is compatible with both the matter tracer model and an isotropic flux.
description: 9 pages, 5 Postscript figures
Effects of conditioned medium from human amniotic mesenchymal tissue cell cultures on prostate cancer cells
Creators: name: Iacopino, Fortunata
name: Sorrentino, Silvia
name: Silini, Antonietta
name: Parolini, Ornella
name: Sica, Gigliola
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2015
Subjects: Prostate cancer cell lines; human amniotic mesenchymal cells; conditioned medium

description: It has been recently demonstrated that human amniotic mesenchymal tissue cells (hAMTC) derived from term placenta inhibit lymphocyte proliferation and significantly reduce the growth of haemopoietic and non haemopoietic cancer cell lines (HeLa and Saos cells) in vitro (1). The aim of our study was to evaluate the effects of hAMTC-conditioned medium (CM) on two human prostate cancer cells lines: LNCaP, androgen responsive and well differentiated, and PC-3, androgen unresponsive and less differentiated. Cells were grown in their standard culture conditions in the absence or in the presence of various concentrations (0.001–50%) of hAMTC-CM or their own exhausted medium. Cell numbers were determined by using a haemocytometer, after three days. Moreover, E- and N-cadherin expression was evaluated in PC-3 cells cultured in medium with 0.01, 1 or 25% hAMTC-CM by Immunocytochemistry and Western blot analysis. Our findings indicate that hAMTC-CM reduces the growth of both PC-3 and LNCaP cells. The effect is more pronounced in PC-3 cells in which inhibition is about 25% vs control (p<0.001) at a very low concentration (0.001%) and reaches the maximum (about 55% vs control, p<0.001) with the highest concentration used (50%). In LNCaP cells only the highest concentration of hAMTC-CM (50%) inhibits cell proliferation (about 40% vs control, p<0.001). Interestingly, growth of LNCaP cells is reduced by their own exhausted medium, while proliferation of PC-3 cells is not affected by their spent medium. Both E- and N-cadherin expression have been detected at the membrane level in untreated PC-3 cells and the localization does not change in hAMTC-CM-treated cells. Preliminary data obtained by Western blot analysis seem to indicate an increase in both E- and N-cadherin levels. Our findings show that hAMTC-CM reduces prostate cancer cell proliferation in relationship to their androgen sensitivity and modifies the expression levels of adhesion molecules. Experiments are in progress to determine the mechanisms which underlie the observed effects and assess if hAMTC-CM can determine any variation in the differentiation status of prostate cancer cells.
description: Italian Journal of Anatomy and Embryology, Vol. 120, No. 1 (Supplement) 2015
Quell’ombra scura sul volto di Nettuno
Creators: Maura Sandri
Publisher: name: Media Inaf
Year: 2019

Le immagini scattate dallo Hubble Space Telescope hanno documentano la formazione di una grande macchia scura su Nettuno, apparsa nel 2018 ma anticipata, due anni prima, da bianche e brillanti nubi ad alta quota costituite da cristalli di metano ghiacciato. Gli scienziati sospettano che queste nuvole di metano accompagnino le tempeste che formano le macchie scure, rimanendo sospese sopra di loro come nubi lenticolari che coprono le vette delle montagne terrestri
Chloropepla paveli Grazia, Schwertner & Greve 2008
Creators: name: Grevea, Caroline
name: Schwertnerb, Cristiano F.
name: Grazia, Jocelia
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Pentatomidae
Chloropepla
Chloropepla paveli

description:  Chloropepla paveli Grazia, Schwertner & Greve, 2008 Chloropepla paveli Grazia et al., 2008b: 535–539. Diagnosis Small size (male: 10.4; female: 11.3). Humeral angles triangular. Male. Pygophore trapezoidal. Marginal processes of dorsal rim triangular. Dorsal expansion of hypandrium narrow. Apex of paramere spatulate; apical and medial spines present. Vesica in a narrow tube, silgthly wider than ductus seminis. Gonocoxites 8 quadrangular; posterior third of sutural margins divergent. Female (Fig. 13). Material examined: “ Dianópolis GO, Brasil 16-22.I.1962 J. Bechyné col.” (MZSP). Gonocoxites 9 (Fig. 13, gc9) trapezoidal, longer than wide. Gonapophyses 9 (Fig. 13, g9) with 1 +1 hatchet-like sclerotized areas. Thickening of vaginal intima (Fig. 13, tvi) conical, tube like; long, with almost the same length as gonapophyses 9. Capsula seminalis (Fig. 13, cs) conical, two processes slightly surpassing the free margin of posterior annular flange (Fig. 13, paf), one surpassing middle of pars intermedialis (Fig. 13, pi). Distribution Bolivia (Santa Cruz, Cochabamba), Brazil (RN, TO, MG, RS). Phylogenetic considerations Chloropepla paveli forms a monophyletic group with C. vigens and C. luteipennis, which is supported by presence of processus phallothecae 1 (321).
description: Published as part of Grevea, Caroline, Schwertnerb, Cristiano F. & Grazia, Jocelia, 2013, Cladistic analysis and synopsis of Chloropepla Stål (Hemiptera: Heteroptera: Pentatomidae) with the description of three new species, pp. 1-43 in Insect Systematics & Evolution 44 on pages 27-28, DOI: 10.1163/1876312X-04401002, http://zenodo.org/record/3653979
description: {"references": ["Grazia, J., Schwertner, C. F. & Greve, C. (2008 b) Two new species of genus Chloropepla (Hemiptera: Pentatomidae: Pentatominae) from Brazil. Acta Entomologica Musei Nationalis Pragae 48: 533 - 542."]}
title: ÐÐµÑÐ°Ð»Ð»ÑÑÐ³Ð¸Ñ ÑÐ²Ð°ÑÐºÐ¸ Ð¸ ÑÐ²Ð°ÑÐ¸Ð²Ð°ÐµÐ¼Ð¾ÑÑÑ Ð½ÐµÑÐ¶Ð°Ð²ÐµÑÑÐ¸Ñ ÑÑÐ°Ð»ÐµÐ¹
Creators: name: ÐÐ¸Ð¿Ð¿Ð¾Ð»ÑÐ´, ÐÐ¶Ð¾Ð½
name: ÐÐ¾ÑÐµÐºÐ¸, ÐÐ°Ð¼Ð¸Ð°Ð½
Publisher: name: ÐÐ·Ð´-Ð²Ð¾ ÐÐ¾Ð»Ð¸ÑÐµÑÐ½. ÑÐ½-ÑÐ°
Year: 2011
Subjects: Ð¡ÑÐ°Ð»Ñ Ð½ÐµÑÐ¶Ð°Ð²ÐµÑÑÐ°Ñ
Ð¡ÑÐ°Ð»Ñ

description: Ð Ð¼Ð¾Ð½Ð¾Ð³ÑÐ°ÑÐ¸Ð¸ Ð¸Ð·Ð²ÐµÑÑÐ½ÑÑ Ð°Ð¼ÐµÑÐ¸ÐºÐ°Ð½ÑÐºÐ¸Ñ ÑÐ¿ÐµÑÐ¸Ð°Ð»Ð¸ÑÑÐ¾Ð² Ð² Ð¾Ð±Ð»Ð°ÑÑÐ¸ Ð¼ÐµÑÐ°Ð»Ð»ÑÑÐ³Ð¸Ð¸ Ð¸ Ð¼ÐµÑÐ°Ð»Ð»Ð¾Ð²ÐµÐ´ÐµÐ½Ð¸Ñ ÑÐ²Ð°ÑÐºÐ¸ John Ð¡. Lippold, Damian J. Kotecki "Welding Metallurgy and Weldability of Stainless Steels" Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½ Ð¿Ð¾Ð´ÑÐ¾Ð±Ð½ÑÐ¹ Ð°Ð½Ð°Ð»Ð¸Ð· Ð¼ÐµÑÐ°Ð»Ð»Ð¾Ð²ÐµÐ´ÐµÐ½Ð¸Ñ Ð¸ Ð¼ÐµÑÐ°Ð»Ð»ÑÑÐ³Ð¸Ð¸ ÑÐ²Ð°ÑÐºÐ¸ Ð²ÑÑÐ¾ÐºÐ¾Ð»ÐµÐ³Ð¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÑ ÑÑÐ¾Ð¼Ð¸ÑÑÑÑ, ÑÑÐ¾Ð¼Ð¾Ð½Ð¸ÐºÐµÐ»ÐµÐ²ÑÑ, ÑÐ»Ð¾Ð¶Ð½Ð¾Ð»ÐµÐ³Ð¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÑ Ð½ÐµÑÐ¶Ð°Ð²ÐµÑÑÐ¸Ñ ÑÑÐ°Ð»ÐµÐ¹ Ð¸ ÑÐ¿Ð»Ð°Ð²Ð¾Ð² ÑÐ°Ð·Ð»Ð¸ÑÐ½Ð¾Ð³Ð¾ Ð½Ð°Ð·Ð½Ð°ÑÐµÐ½Ð¸Ñ. ÐÐµÑÐ°Ð»ÑÐ½Ð¾ Ð¿ÑÐ¾Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½ Ð¼ÐµÑÐ°Ð½Ð¸Ð·Ð¼ ÐºÑÐ¸ÑÑÐ°Ð»Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ ÑÐ°ÐºÐ¸Ñ ÑÑÐ°Ð»ÐµÐ¹ Ð¸ ÑÐ¿Ð»Ð°Ð²Ð¾Ð² Ð¿ÑÐ¸ ÑÐ²Ð°ÑÐºÐµ Ð¿Ð»Ð°Ð²Ð»ÐµÐ½Ð¸ÐµÐ¼ Ð¸ ÐµÐ³Ð¾ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Ð½Ð° Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ Ð´ÐµÑÐµÐºÑÐ¾Ð² - Ð³Ð¾ÑÑÑÐ¸Ñ ÑÑÐµÑÐ¸Ð½, Ð¾ÑÑÑÐ¿ÑÐ¸Ð²Ð°Ð½Ð¸Ñ Ð²ÑÐ»ÐµÐ´ÑÑÐ²Ð¸Ðµ ÑÐ¸Ð³Ð¼Ð°ÑÐ¸Ð·Ð°ÑÐ¸Ð¸ (Ð²ÑÐ´ÐµÐ»ÐµÐ½Ð¸Ñ ÑÐ¸Ð³Ð¼Ð°-ÑÐ°Ð·Ñ) Ð¸ Ñ. Ð¿. ÐÐ°Ð½Ñ Ð¿Ð¾Ð´ÑÐ¾Ð±Ð½ÑÐµ ÑÐµÐºÐ¾Ð¼ÐµÐ½Ð´Ð°ÑÐ¸Ð¸ Ð¿Ð¾ Ð²ÑÐ±Ð¾ÑÑ Ð¾ÑÐ½Ð¾Ð²Ð½Ð¾Ð³Ð¾ Ð¸ Ð¿ÑÐ¸ÑÐ°Ð´Ð¾ÑÐ½Ð¾Ð³Ð¾ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ð¾Ð² Ð¸ Ð¸Ð·Ð»Ð¾Ð¶ÐµÐ½Ñ ÑÑÐµÐ±Ð¾Ð²Ð°Ð½Ð¸Ñ Ðº ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ð¸ ÑÐ²Ð°ÑÐºÐ¸. ÐÑÐ¸Ð²ÐµÐ´ÐµÐ½Ñ ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ¾ÑÑÐ°Ð² Ð¸ Ð¼ÐµÑÐ°Ð½Ð¸ÑÐµÑÐºÐ¸Ðµ ÑÐ²Ð¾Ð¹ÑÑÐ²Ð° Ð½Ð°Ð¸Ð±Ð¾Ð»ÐµÐµ ÑÐ°ÑÑÐ¾ Ð¿ÑÐ¸Ð¼ÐµÐ½ÑÐµÐ¼ÑÑ Ð¼Ð°ÑÐ¾Ðº Ð½ÐµÑÐ¶Ð°Ð²ÐµÑÑÐ¸Ñ ÑÑÐ°Ð»ÐµÐ¹ Ð¸ ÑÐ¿Ð»Ð°Ð²Ð¾Ð² Ð½Ð° Ð½Ð¸ÐºÐµÐ»ÐµÐ²Ð¾Ð¹ Ð¾ÑÐ½Ð¾Ð²Ðµ, Ð° ÑÐ°ÐºÐ¶Ðµ ÑÐºÐ°Ð·Ð°Ð½Ñ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ñ Ð´Ð»Ñ Ð¸Ñ ÑÐ²Ð°ÑÐºÐ¸. ÐÐ¾Ð½Ð¾Ð³ÑÐ°ÑÐ¸Ñ Ð¿ÑÐµÐ´Ð½Ð°Ð·Ð½Ð°ÑÐµÐ½Ð° Ð´Ð»Ñ ÑÐ¿ÐµÑÐ¸Ð°Ð»Ð¸ÑÑÐ¾Ð², ÑÐ°Ð±Ð¾ÑÐ°ÑÑÐ¸Ñ Ð² Ð¾Ð±Ð»Ð°ÑÑÐ¸ Ð¼ÐµÑÐ°Ð»Ð»ÑÑÐ³Ð¸Ð¸, Ð¼ÐµÑÐ°Ð»Ð»Ð¾Ð²ÐµÐ´ÐµÐ½Ð¸Ñ Ð¸ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ð¸ ÑÐ²Ð°ÑÐºÐ¸. Ð ÐµÐºÐ¾Ð¼ÐµÐ½Ð´ÑÐµÑÑÑ Ð´Ð»Ñ Ð°ÑÐ¿Ð¸ÑÐ°Ð½ÑÐ¾Ð², ÑÑÑÐ´ÐµÐ½ÑÐ¾Ð² ÑÑÐ°ÑÑÐ¸Ñ ÐºÑÑÑÐ¾Ð² ÑÐ¿ÐµÑÐ¸Ð°Ð»ÑÐ½Ð¾ÑÑÐ¸ 110700 "ÐÐµÑÐ°Ð»Ð»ÑÑÐ³Ð¸Ñ ÑÐ²Ð°ÑÐ¾ÑÐ½Ð¾Ð³Ð¾ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ð°", Ð° ÑÐ°ÐºÐ¶Ðµ Ð´Ð»Ñ ÑÐ»ÑÑÐ°ÑÐµÐ»ÐµÐ¹ ÐºÑÑÑÐ¾Ð² Ð¿Ð¾Ð²ÑÑÐµÐ½Ð¸Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¸ Ð¿ÑÐ¸ Ð¿Ð¾Ð´Ð³Ð¾ÑÐ¾Ð²ÐºÐµ Ðº Ð°ÑÑÐµÑÑÐ°ÑÐ¸Ð¸ ÑÐ¿ÐµÑÐ¸Ð°Ð»Ð¸ÑÑÐ¾Ð² ÑÐ²Ð°ÑÐ¾ÑÐ½Ð¾Ð³Ð¾ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ð°.
NLO-QCD corrections to $Wγj$ production
Creators: name: Campanario, F.
name: Englert, C.
name: Spannowsky, M.
name: Zeppenfeld, D.
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We calculate the $W^\pmγj + X$-production cross sections at next-to-leading order QCD for Tevatron and LHC collisions. We include leptonic decays of the $W$ to light leptons, with all off-shell effects taken into account. The corrections are sizable and have significant impact on the differential distributions.
description: 5 pages, 7 figures, published version
Wharton’s jelly mesenchymal stromal cells immunomodulatory molecules: their journey from umbilical cord to differentiated cells
Creators: name: Anzalone, Rita
name: Corsello, Tiziana
name: Lo Iacono, Melania
name: Timoneri, Francesca
name: Amico, Giandomenico
name: Conaldi, Pier Giulio
name: Rastellini, Cristiana
name: Cicalese, Luca
name: Cappello, Francesco
name: Zummo, Giovanni
name: Gerbino, Aldo
name: Farina, Felicia
name: La Rocca, Giampiero
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2015

description: Wharton’s jelly mesenchymal stromal cells (WJ-MSCs) have a unique ability to cross lineage borders. Their immunomodulatory and anti-inflammatory features, further render these cells promising for regenerative medicine applications. Few data are present in literature on the expression of immunomodulatory molecules in umbilical cord (UC) tissue and their maintenance in paired cultured WJ-MSCs, an important aspect in cellular therapy applications. In addition, few data exist on the maintenance of expression of immunomodulatory molecules in mature cell types differentiated from MSCs. Therefore we investigated, in vivo (in UC at full term) and in vitro (in either undifferentiated or differentiated WJ-MSCs), the expression of different markers and their maintenance alongside cell culture, ex vivo expansion and differentiation. IHC, ICC, RT-PCR and flow cytometry were used to detect expression of markers in both paired UC sections and WJ-MSCs. Differentiation was performed towards the standard mesenchymal lineages as well as hepatocyte-like cells. Paired ICC and IHC analyses showed that for most of the analyzed molecules the expression at the protein level is maintained in both UC tissue and WJ-MSCs. Structural molecules were expressed in both WJ and umbilical epithelium (UE), as well as in WJ-MSCs. We showed for the first time that UE and WJ were positive for both HLA-ABC and HLA-E, while HLA-DR was not detectable. The same data were confirmed on WJ-MSCs. Both B7-1 and B7-2 were absent in UC and WJ-MSCs, while we showed for the first time that B7-H3 was highly expressed in both WJ and WJMSCs. Differentiation experiments showed that immunomodulatory molecules were expressed upon application of complex differentiation protocols, in parallel to the acquisition of mature markers or functions. Some important conclusions may be drawn from the current experiments: i) WJMSCs mostly maintain the expression of molecules just present in their “niche”, under standard culture conditions; ii) the parallel expression of immunomodulatory molecules sheds new light on the ability of WJ-MSCs to modulate host immune responses; iii) the in vivo expression of molecules such as HLA-E and B7-H3 opens new questions on the role of WJ during pregnancy; iv) the expression of these molecules in differentiated cells provides key features for in vivo applications, in particular for hepatocyte-like cells.
description: Italian Journal of Anatomy and Embryology, Vol. 120, No. 1 (Supplement) 2015
Setaria parviflora
Creators: name: Cardona, Àngel Manuel Hernández
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Poales
Poaceae
Setaria
Setaria parviflora

description: Setaria parviflora (Poir.) Kerguélen
(xereix gràcil). Oriünda d’Amèrica del Nord, actualment és estesa a moltes zones tropicals i subtropicals, i també al sud d’Europa. Creix en herbassars nitròfils i vores de camins. Fou descoberta l’any 1991 als Caus del Guitart, massís de l’Obac (Hernández, 2007: 32).
description: Published as part of Cardona, Àngel Manuel Hernández, 2022, Catàleg actualitzat i claus d'identificació de les gramínies de Sant Llorenç del Munt i l'Obac (Barcelona), pp. 64-86 in Nemus 12 on page 74, DOI: 10.5281/zenodo.12170499
Electrohydrodynamic model of vesicle deformation in alternating electric fields
Creators: name: Vlahovska, Petia
name: Gracia, Ruben Serral
name: Aranda, Said
name: Dimova, Rumiana
Publisher: name: arXiv
Year: 2008
Subjects: subject: Biological Physics (physics.bio-ph)
subject: FOS: Physical sciences

description: We develop an analytical theory to explain the experimentally-observed morphological transitions of giant vesicles induced by AC electric fields (1). The model treats the inner and suspending media as lossy dielectrics, while the membrane as an ion-impermeable flexible incompressible-fluid sheet. The vesicle shape is obtained by balancing electric, hydrodynamic, and bending stresses exerted on the membrane. Considering a nearly spherical vesicle, the solution to the electrohydrodynamic problem is obtained as a regular perturbation expansion in the excess area. The theory predicts that stationary vesicle deformation depends on field frequency and conductivity conditions. If the inner fluid is more conducting than the suspending medium, the vesicle always adopts a prolate shape. In the opposite case, the vesicle undergoes a transition from a prolate to oblate ellipsoid at a critical frequency, which the theory identifies with the inverse membrane charging time. At frequencies higher than the inverse Maxwell-Wagner polarization time, the electrohydrodynamic stresses become too small to alter the vesicle's quasi-spherical rest shape. The analysis shows that the evolution towards the stationary vesicle deformation strongly depends on membrane properties such as viscosity. The model can be applied to rationalize the transient and steady deformation of biological cells in electric fields.
Soho sbircia il Sole all’equinozio
Creators: Paolo Soletta
Publisher: name: Media Inaf
Year: 2019

Frutto di una partnership Esa/Nasa, dal 1995 la sonda Soho osserva ininterrottamente il Sole da una posizione privilegiata, regalandoci immagini ordinariamente eccezionali. Continuerà a farlo fino al 2020, prima di andare in pensione e lasciare il campo a Solar Orbiter
title: ÐÑÐ²Ð¾Ð´ ÑÐ¾ÑÑÐ¸Ð¹ÑÐºÐ¸Ñ ÑÑÐ°ÑÑÐ°Ð¿Ð¾Ð² Ð½Ð° ÑÑÐ½Ð¾Ðº ÐÐµÐ»Ð¸ÐºÐ¾Ð±ÑÐ¸ÑÐ°Ð½Ð¸Ð¸
title: Ð¼Ð°Ð³Ð¸ÑÑÐµÑÑÐºÐ°Ñ Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ñ
titleType: Subtitle
Creators: name: ÐÑÐ¸ÑÐµÐ½ÐºÐ¾, ÐÐ°Ð²ÐµÐ»
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: ÑÑÐ°ÑÑÐ°Ð¿Ñ
Ð¸Ð½Ð½Ð¾Ð²Ð°ÑÐ¸Ð¸

description: Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð¿ÑÐ¾Ð´ÐµÐ»Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ Ð±ÑÐ» ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½ Ð¿Ð¾ÑÑÐ°Ð¿Ð½ÑÐ¹ Ð¿Ð»Ð°Ð½ Ð¿ÑÐ¾ÑÐµÑÑÐ° Ð²ÑÑÐ¾Ð´Ð° Ð½Ð° Ð±ÑÐ¸ÑÐ°Ð½ÑÐºÐ¸Ð¹ ÑÑÐ½Ð¾Ðº ÑÐ¾ÑÑÐ¸Ð¹ÑÐºÐ¸Ñ ÑÑÐ°ÑÑÐ°Ð¿Ð¾Ð², ÑÐ°Ð±Ð¾ÑÐ°ÑÑÐ¸Ñ Ð² Ð¸Ð½Ð½Ð¾Ð²Ð°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ Ð¾ÑÑÐ°ÑÐ»Ð¸ Ð¸ Ð¶ÐµÐ»Ð°ÑÑÐ¸Ñ Ð²ÑÐ¹ÑÐ¸ Ð½Ð° Ð±ÑÐ¸ÑÐ°Ð½ÑÐºÐ¸Ð¹ ÑÑÐ½Ð¾Ðº Ð¸Ð·-Ð·Ð° Ð¾ÑÑÑÑÑÑÐ²Ð¸Ñ ÑÐ¿ÑÐ¾ÑÐ° Ð½Ð° ÑÐ²Ð¾Ð¹ Ð¿ÑÐ¾Ð´ÑÐºÑ Ð¸ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ð¸ Ð½Ð° ÑÐ¾ÑÑÐ¸Ð¹ÑÐºÐ¾Ð¼ ÑÑÐ½ÐºÐµ.
L’incredibile viaggio di Giove
Creators: Maura Sandri
Publisher: name: Media Inaf
Year: 2019

Un nuovo studio – guidato da Simona Pirani, ricercatrice italiana oggi in Svezia, e firmato fra gli altri da Diego Turrini dell'Inaf Iaps di Roma – mostra come Giove si sia formato quattro volte più lontano dal Sole rispetto alla sua orbita attuale. Solo successivamente sarebbe migrato verso l'interno del Sistema solare, in un periodo di 700mila anni
EGFR positive feedback loops and βeta Catenin driven miR-17-92 cluster converge to regulate EMT and drug resistance
Creators: name: Lauriola, Mattia
name: Mazza, Chiara
name: Pontis, Francesca
name: Rodia, Maria Teresa
name: Restivo, Angelo
name: Solmi, Rossella
name: Caramelli, Elisabetta
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2015
Subjects: EGFR; Growth factors; EMT; Colon Cancer; microRNAs

description: Epidermal growth factor receptor (EGFR)-targeted cancer drug represents a mile- stone in oncology. Nevertheless the responses are invariably limited by the emer- gence of secondary drug-resistance (Misale, Di Nicolantonio et al. 2014). We found that drug-treated ‘‘EGFR-addicted’’ cancer cells engage a positive feedback loop lead- ing to NF-KB/βCatenin axis activation (Lauriola, Enuka et al. 2014), consequently promoting cell survival and limiting overall drug response. Specifically, secondary activation of βCatenin drives the production of an oncogenic cluster of microRNAs 17-92 (Lauriola, Donghwa et al. 2015) implicated in EMT transformation and resist- ance in colon clones. Hence βCatenin and EGFR combination pharmacological inhi- bition overcome the colon spheres growth and enhance tumor regression. These findings suggest that inhibition of EGFR feedback loop along with NF-kB/βCatenin axis may increase the response to a broad spectrum of drugs that target pathways of oncogene addiction.
description: Italian Journal of Anatomy and Embryology, Vol. 120, No. 1 (Supplement) 2015
Solar Activity Phases and Intermediate-degree Mode Frequencies
Creators: name: Jain, Kiran
name: Tripathy, S. C.
name: Hill, F.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We analyze intermediate degree p-mode eigenfrequencies measured by GONG and MDI/SOHO over a solar cycle to study the source of their variability. We carry out a correlation analysis between the change in frequencies and several measures of the Sun's magnetic activity that are sensitive to changes at different levels in the solar atmosphere. The observations span a period of about 12 years starting from mid-1996 (the minimum of cycle 23) to early-2008 (near minimum of cycle 24), corresponding to a nearly complete solar activity cycle. We demonstrate that the frequencies do vary in phase with the solar activity indices, however the degree of correlation differs from phase to phase of the cycle. During the rising and declining phases, the mode frequency shifts are strongly correlated with the activity proxies whereas during the high-activity period, the shifts have significantly lower correlation with all activity proxies, except for the 10.7-cm radio flux. In particular, the proxies that are only influenced by the variation of the strong component of the magnetic field in the photosphere have a much lower correlation at the high-activity period. On the other hand, the shifts are better correlated with the proxies sensitive to changes in the weak component of the magnetic field. Our correlation analysis suggests that more than 90% of the variation in the oscillation frequencies in all activity phases can be explained by changes in both components of the magnetic field. Further, the slopes obtained from the linear regression analysis also differ from phase to phase and show a strong correlation with the correlation coefficients between frequency shifts and solar activity.
description: Accepted for publication in Astrophysical Journal (April 20, 2009 issue)
Kondo screening in high-spin side-coupled two-impurity clusters
Creators: name: Zitko, Rok
Publisher: name: arXiv
Year: 2009
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We study the system of two magnetic impurities described by a two-impurity Kondo model where only the first impurity couples directly to the conduction band, while the second impurity interacts with the first through Heisenberg exchange coupling in a "side-coupled" configuration. We consider various choices of the impurity spins (S_1S_2) and we contrast the regimes where the inter-impurity exchange coupling J is either lower or higher than the Kondo temperature T_K^(0) of the first impurity in the absence of the second. This model is a high-spin generalization of the two-impurity model for side-coupled double quantum dots which corresponds to the simplest S_1=S_2=1/2 case, where the moments are Kondo screened successively in two stages for J= S_1. For S_1 >= 1, the second Kondo temperature T_K^(2) is not exponentially reduced, as for S_1 = 1/2, but is approximately a power-law function of the coupling J. Furthermore, for S_1 >=1 1 all three scales (T_K^(0), J, T_K^(2)) explicitly appear in the temperature-dependence of the thermodynamic properties. For S_1 > S_2, there is no second stage of screening for JT_K^(0) the Kondo screening of the effective spin S_1-S_2 is found.
description: 11 pages, 3 figures