cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
HIV long-term non-progressors share similar features with simian immunodeficiency virus infection of chimpanzees.
Creators: name: Roy, Ayan
name: Surajit Basak
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Statistics
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: HIV-1 infection in human beings has been an outcome of cross-species transmission event of simian immunodeficiency virus from chimpanzees (SIVcpz). Present study reveals differential features of envelope genes representing different categories of HIV-1 disease progression in human beings, namely, rapid progressors (RP), slow progressors (SP) and long-term non-progressors (LTNP) with respect to SIVcpz, based on their amino acid usage patterns. It was evident that SP, LTNP and SIVcpz envelope genes displayed similar patterns of amino acid usage which strongly contrasted with the features exhibited by the envelope genes representing RP category. Robust analysis revealed that selection constraint of human host on SP and LTNP associated envelope genes and chimpanzee host on SIVcpz envelope genes were more severe compared to selection pressure operational on RP associated envelope genes. Evolutionary forces of selection appeared to be comparatively more relaxed on the RP envelope genes in contrast to SP, LTNP and SIVcpz types. Better binding of RP envelope glycoprotein 120 (gp120) compared to envelope gp120 representing SP, LTNP and SIVcpz with host cellular receptor CD4, as inferred employing molecular docking approaches, promises to confer meaningful insights into the event of speedy progression of HIV in rapid progressors. It was interesting to note that envelope glycoprotein exhibited a tendency of hindering proper interaction of host (human/chimpanzee) CD4 and major histocompatibility complex II (MHC II), with a better efficacy in rapid progressors, thus, facilitating highest degrees of immune suppression. Proper identification of the contrasting features might confer a scope to modulate rapid progression of HIV to a long-term non-progressive controlled case, as observed in LTNP and SIVcpz infection, simultaneously aiding therapeutic research against AIDS targeted at drug and vaccine development.
Evidence from d+Au measurements for final-state suppression of high $p_T$ hadrons in Au+Au collisions at RHIC
Creators: name: Adams, J.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We report measurements of single-particle inclusive spectra and two-particle azimuthal distributions of charged hadrons at high transverse momentum (high $p_T$) in minimum bias and central d+Au collisions at $\sqrt{s_{NN}}$=200 GeV. The inclusive yield is enhanced in d+Au collisions relative to binary-scaled p+p collisions, while the two-particle azimuthal distributions are very similar to those observed in p+p collisions. These results demonstrate that the strong suppression of the inclusive yield and back-to-back correlations at high $p_T$ previously observed in central Au+Au collisions are due to final-state interactions with the dense medium generated in such collisions.
description: Final journal version. Data tables for figures may be downloaded from the STAR home page: http://www.star.bnl.gov --> Publications --> Access to STAR published data
§ 2 Kryptowährungen in verteilten Systemen – Herausforderungen des öffentlichen Finanzrechts
Creators: name: Anzinger, Heribert
Publisher: name: Heidelberger Beiträge zum Finanz- und Steuerrecht
Year: 2020

description: Heidelberger Beiträge zum Finanz- und Steuerrecht, Bd. 14 (2020): Alternative Währungen: Herausforderungen des Finanz- und Steuerrechts
Sphaerobelum turcosa Srisonchai & Pimvichai 2023
Creators: name: Srikampha, Khanet
name: Wesener, Thomas
name: Likhitrakarn, Natdanai
name: Sutcharit, Chirasak
name: Srisonchai, Ruttapon
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Sphaerotheriida
Zephroniidae
Sphaerobelum
Sphaerobelum turcosa

description: Sphaerobelum turcosa Srisonchai & Pimvichai, 2023
Figs 15 M, N, 16
Sphaerobelum turcosa Srisonchai & Pimvichai, 2023 in Srisonchai et al. 2023: 45.
New material examined.
Thailand • 2 ♂♂ (MZKKU), Loei Province, Mueang Loei District, Phu Pha Lom Forest Park, 540 m a. s. l., 17°34'18.4"N, 101°52'18.0"E, 18 September 2023, P. Sukkharom coll.
Distribution.
This species is known only from the type locality, which is characterised by the highly irregular geomorphology of limestone habitat at Phu Pha Lom Forest Park in Loei Province. Based on our observations of specimens at both the forest floor and on rocks, we suggest that this species is likely inhabiting only rock crevices or walls.
description: Published as part of Srikampha, Khanet, Wesener, Thomas, Likhitrakarn, Natdanai, Sutcharit, Chirasak & Srisonchai, Ruttapon, 2025, The millipede genus Sphaerobelum Verhoeff, 1924, in Thailand, with descriptions of three new species (Diplopoda, Sphaerotheriida, Zephroniidae), pp. 273-300 in Zoosystematics and Evolution 101 (1) on pages 273-300, DOI: 10.3897/zse.101.143073
A Catalog of M-dwarf Flares with ASAS-SN
Creators: name: Martínez, Romy Rodríguez
name: Lopez, Laura A.
name: Shappee, Benjamin J.
name: Schmidt, Sarah J.
name: Jayasinghe, Tharindu
name: Kochanek, Christopher S.
name: Auchettl, Katie
name: Holoien, Thomas W. -S.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We analyzed the light curves of 1376 early-to-late, nearby M dwarfs to search for white-light flares using photometry from the All-Sky Automated Survey for Supernovae (ASAS-SN). We identified 480 M dwarfs with at least one potential flare employing a simple statistical algorithm that searches for sudden increases in $V$-band flux. After more detailed evaluation, we identified 62 individual flares on 62 stars. The event amplitudes range from $0.12
description: 16 pages, 5 figures, 7 tables, submitted to the AAS Journals
Structural dynamics and susceptibility of anti-HIV drugs against HBV reverse transcriptase
Creators: name: Jirayu Kammarabutr
name: Panupong Mahalapbutr
name: Okumura, Hisashi
name: Wolschann, Peter
name: Thanyada Rungrotmongkol
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Hepatitis B virus (HBV), a small enveloped DNA virus, attacks the human liver causing both acute and chronic diseases. Current therapeutic drugs use the nucleos(t)ide analogues (NAs) as a competitive inhibitor against HBV reverse transcriptase (HBV-RT), an essential enzyme pivotally involved in viral replication. Unfortunately, this treatment still causes the development of resistant variants of HBV against NAs. As HBV-RT is homologous to the human immunodeficiency virus reverse transcriptase (HIV-RT), it is reasonable to treat HBV-RT with anti-HIV drugs. In the present study, we aimed to investigate the structural dynamics and susceptibility of the known anti-HIV drugs (stavudine [d4T], didanosine [DDI], and zidovudine [ZDV]) against HBV-RT enzyme in comparison to the anti-HBV drug lamivudine (3TC) and deoxythymidine triphosphate (dTTP) substrate using several computational approaches. The ΔGbindresidue calculations revealed that seven polar residues (K32, R41, D83, S85, D205, N236, and K239) and three hydrophobic residues (A86, A87, and F88) of HBV-RT as well as the adjacent DNA strands play an important role in the ligand binding. In addition, the H-bond pattern of d4T is similar to that of 3TC, especially at the residues A86 and A87. Such interactions promote the favorable conformation of ligand in the HBV-RT binding pocket, while the several different conformations of ligand are found in the unbound state. The predicted binding free energy results based on QM/MM-GBSA and MM/GB(PB)SA methods suggested that the susceptibility towards HBV-RT of d4T and ZDV is higher than that of 3TC and dTTP. Altogether, this work sheds light on the potentiality of d4T and ZDV as a promising drug for HBV-infected patients harboring 3TC resistance. Communicated by Ramaswamy H. Sarma
§ 1 Kryptowährungen und stable coins in verteilten Systemen – Ökonomische Potentiale und Risiken
Creators: name: Schaaf, Jürgen
Publisher: name: Heidelberger Beiträge zum Finanz- und Steuerrecht
Year: 2020

description: Heidelberger Beiträge zum Finanz- und Steuerrecht, Bd. 14 (2020): Alternative Währungen: Herausforderungen des Finanz- und Steuerrechts
Additional file 1: of A hotspots analysis-relation discovery representation model for revealing diabetes mellitus and obesity
Creators: name: He, Guannan
name: Liang, Yanchun
name: Chen, Yan
name: Yang, William
name: Liu, Jun
name: Yang, Mary
name: Guan, Renchu
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy

description: Word cloud results of ten years and clinical report proofs on relationships between diabetes, obesity and other diseases. (PDF 10960 kb)
Explainable Artificial Intelligence by Genetic Programming: A Survey
Creators: name: Mei, Yi
name: Chen, Qi
name: Lensen, Andrew
name: Xue, Bing
name: Zhang, Mengjie
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2022
Subjects: classificationCode: 460999
subject: Information systems not elsewhere classified
classificationCode: 460299
subject: Artificial intelligence not elsewhere classified
classificationCode: 400899
subject: Electrical engineering not elsewhere classified

description: Explainable artificial intelligence has received great interest in the recent decade, due to its importance in critical application domains such as self-driving cars, law and healthcare. Genetic programming is a powerful evolutionary algorithm for machine learning. Compared with other standard machine learning models such as neural networks, the models evolved by GP tend to be more interpretable due to their model structure with symbolic components. However, interpretability has not been explicitly considered in genetic programming until recently, following the surge in popularity of explainable artificial intelligence. This paper provides a comprehensive review of the studies on genetic programming that can potentially improve the model interpretability, both explicitly and implicitly, as a byproduct. We group the existing studies related to explainable artificial intelligence by genetic programming into two categories. The first category considers the intrinsic interpretability, aiming to directly evolve more interpretable (and effective) models by genetic programming. The second category focuses on posthoc interpretability, which uses genetic programming to explain other black-box machine learning models, or explain the models evolved by genetic programming by simpler models such as linear models. This comprehensive survey demonstrates the strong potential of genetic programming for improving the interpretability of machine learning models and balancing the complex trade-off between model accuracy and interpretability.
Correspondence between QCD sum rules and constituent quark models
Creators: name: Melikhov, Dmitri
name: Simula, Silvano
Publisher: name: arXiv
Year: 2004
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We compare two widely used approaches to the description of hadron properties: QCD sum rules and constituent quark models. Making use of the dispersion formulation of the quark model, we show that both approaches lead to similar spectral representations for hadron observables with an important difference that quark model is based on Feynman diagrams with massive quarks, whereas QCD sum rules are based on the same Feynman diagrams for current quarks with the additional condensate contributions for light quarks and gluons. We give arguments for a similarity of the smearing function in sum rules and the hadron wave function of the quark model. Analyzing the sum rule for the leptonic decay constant of the heavy pseudoscalar meson containing a light $u$ or $s$ quark, we find that the quark condensates at the chiral symmetry-breaking scale $μ_χ\simeq 1$ GeV, $ = - (230 \pm 15 {\rm MeV})^3$ and $ = - (220 \pm 15 {\rm MeV})^3$ correspond to constituent quark masses $m_u\simeq 220$ MeV and $m_s \simeq 350$ MeV, respectively. We also obtain the running of the quark model parameters above the chiral scale $μ_χ$. The observed correspondence between constituent quark models and QCD sum rules allows a deeper understanding of both methods and their parameters. It also provides a QCD basis for constituent quark models, extending their applicability above the scale of chiral symmetry breaking.
description: 8 pages, discussion of scale dependence of quark-model parameters above the chiral symmetry breaking scale is added
Can a Gorilla Ride a Camel? Learning Semantic Plausibility from Text
Creators: name: Porada, Ian
name: Suleman, Kaheer
name: Cheung, Jackie Chi Kit
Publisher: name: arXiv
Year: 2019
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences

description: Modeling semantic plausibility requires commonsense knowledge about the world and has been used as a testbed for exploring various knowledge representations. Previous work has focused specifically on modeling physical plausibility and shown that distributional methods fail when tested in a supervised setting. At the same time, distributional models, namely large pretrained language models, have led to improved results for many natural language understanding tasks. In this work, we show that these pretrained language models are in fact effective at modeling physical plausibility in the supervised setting. We therefore present the more difficult problem of learning to model physical plausibility directly from text. We create a training set by extracting attested events from a large corpus, and we provide a baseline for training on these attested events in a self-supervised manner and testing on a physical plausibility task. We believe results could be further improved by injecting explicit commonsense knowledge into a distributional model.
description: Accepted at COIN@EMNLP 2019
Structure-based screening and validation of bioactive compounds as Zika virus Methyltransferase(MTase) inhibitors through first-principle density functional theory, classical molecular simulation and QM/MM affinity estimation
Creators: name: Bharadwaj, Shiv
name: Akhilesh Kumar Rao
name: Dwivedi, Vivek Dhar
name: Sarad Kumar Mishra
name: Yadava, Umesh
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Recent Zika virus (ZIKV) outbreak and association with human diseases such as neurological disorders have raised global health concerns. However, in the absence of an approved anti-ZIKV drug has generated urgency for the drug development against ZIKV infection. Here, structure-based virtual screening of 8589 bioactive compounds screened at the substrate-binding site of ZIKV nonstructural 5 (NS5)-based structure N-terminal methyltransferase (MTase) domain followed by ADMET (absorption, distribution, metabolism, excretion and toxicity) profiling concluded the four potential lead inhibitors, i.e. (4-acetylamino-benzenesulfonylamino)-acetic acid (F3342-0450), 3-(5-methylfuran-2-yl)-N-(4-sulfamoylphenyl)propanamide (F1736-0142), 8-(2-hydroxy-ethylamino)-1,3-dimethyl-7-(3-methyl-benzyl)-3,7-dihydro-purine-2,6-dione (F0886-0080) and N-[4-(aminosulfonyl)phenyl]-2,3-dihydro-1,4-benzodioxine-2-carboxamide (F0451-2187). Collectively, extra precision docking and Density Functional Theory calculations studies identified the F3342-0450 molecule having strong interactions on the active site of MTase, was further supported by molecular dynamics simulation, binding affinity and hybrid QM/MM calculations, suggest a new drug molecule for the antiviral drug development against ZIKV infection.
The GZK cutoff behind a Magnetized Universe
Creators: name: Deligny, Olivier
name: Letessier-Selvon, Antoine
name: Parizot, Etienne
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We study the effect of random extra-galactic magnetic fields on the propagation of protons of energy larger than $10^{19}$ eV. We show that for reasonable field values (in the 100 nG range) the transition between diffusive and ballistic regimes occurs in the same energy range as the GZK cutoff (a few $10^{19}$ eV). The usual interpretation of the flux reduction above the GZK energy in terms of a sudden reduction of the visible horizon is modified. Moreover, since the size of the diffusion sphere of a continuous source of cosmic rays is of the order of 10 Mpc, the local structure of the Universe and therefore of potential local astrophysical sources plays a dominant role in the expected spectrum. Under reasonable assumptions on the sources configurations the expected GZK cutoff is reduced.
Centrality dependence of charged hadron transverse momentum spectra in d+Au collisions at sqrt(s_NN) = 200 GeV
Creators: name: Back, B. B.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We have measured transverse momentum distributions of charged hadrons produced in d+Au collisions at sqrt(s_NN) = 200 GeV. The spectra were obtained for transverse momenta 0.25 < p_T < 6.0 GeV/c, in a pseudorapidity range of 0.2 < eta < 1.4 in the deuteron direction. The evolution of the spectra with collision centrality is presented in comparison to p+pbarcollisions at the same collision energy. With increasing centrality, the yield at high transverse momenta increases more rapidly than the overall particle density, leading to a strong modification of the spectral shape. This change in spectral shape is qualitatively different from observations in Au+Au collisions at the same energy. The results provide important information for discriminating between different models for the suppression of high-p_T hadrons observed in Au+Au collisions.
description: 5 pages, 4 figures, submitted to PRL
Additional file 1 of Outer membrane protein A (OmpA) of extraintestinal pathogenic Escherichia coli
Creators: name: Nielsen, Daniel
name: Ricker, Nicole
name: Barbieri, Nicolle
name: Allen, Heather
name: Nolan, Lisa
name: Logue, Catherine
Publisher: name: figshare
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Additional file 1: Table S1. Strain information for the ExPEC examined.
A Hybrid Medium Voltage Multilevel Converter with Parallel Voltage-Source Active Filter
Creators: name: Bernet, D.
name: Stefanski, L.
name: Hiller, M.
Publisher: name: Karlsruhe
Year: 2019

description: In consequence of high semiconductor losses, grid-connected medium voltage power converters are typically operated at switching frequencies of several hundred Hertz per switch position. Therefore, conventional converter systems require bulky and expensive LCL-filters in order to meet the harmonic limits given by the grid code. It is only possible to reduce the LCL-filter costs by semiconductor current derating and operation at increased switching frequencies, leading to a reduced utilization and efficiency of the converter system. To overcome these disadvantages of conventional converter systems, the presented hybrid converter uses a parallel voltage-source active output filter and thus allows a significant reduction of the passive component demand. An excellent harmonic performance is achieved for the operation with small passive filter components, revealing the potential for increasing the power density and efficiency of high power medium voltage converters. As a result, significant reductions of the filter losses and passive components as well as an increased utilization are achieved compared to a reference LCL-filter based converter system.
Is There A String Theory Landscape
Creators: name: Banks, Tom
name: Dine, Michael
name: Gorbatov, Elie
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We examine recent claims of a large set of flux compactification solutions of string theory. We conclude that the arguments for AdS solutions are plausible. The analysis of meta-stable dS solutions inevitably leads to situations where long distance effective field theory breaks down. We then examine whether these solutions are likely to lead to a description of the real world. We conclude that one must invoke a strong version of the anthropic principle. We explain why it is likely that this leads to a prediction of low energy supersymmetry breaking, but that many features of anthropically selected flux compactifications are likely to disagree with experiment.
description: 39 pages, Latex, ``Terminology surrounding the anthropic principle revised to conform with accepted usage. More history of the anthropic principle included. Various references added."
RNA knockdown by synthetic peptidyl-oligonucleotide ribonucleases: behavior of recognition and cleavage elements under physiological conditions
Creators: name: Mengisteab Gebrezgiabher
name: Zalloum, Waleed A.
name: Clarke, David J.
name: Miles, Steven M.
name: Fedorova, Antonina A.
name: Zenkova, Marina A.
name: Bichenkova, Elena V.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine

description: Sequence-specific protein-based ribonucleases are not found in nature. Absolute sequence selectivity in RNA cleavage in vivo normally requires multi-component complexes that recruit a guide RNA or DNA for target recognition and a protein–RNA assembly for catalytic functioning (e.g. RNAi molecular machinery, RNase H). Recently discovered peptidyl-oligonucleotide synthetic ribonucleases selectively knock down pathogenic RNAs by irreversible cleavage to offer unprecedented opportunities for control of disease-relevant RNA. Understanding how to increase their potency, selectivity and catalytic turnover will open the translational pathway to successful therapeutics. Yet, very little is known about how these chemical ribonucleases bind, cleave and leave their target. Rational design awaits this understanding in order to control therapy, particularly how to overcome the trade-off between sequence specificity and potency through catalytic turnover. We illuminate this here by characterizing the interactions of these chemical RNases with both complementary and non-complementary RNAs using Tm profiles, fluorescence, UV-visible and NMR spectroscopies. Crucially, the level of counter cations, which are tightly-controlled within cellular compartments, also controlled these interactions. The oligonucleotide component dominated interaction between conjugates and complementary targets in the presence of physiological levels of counter cations (K+), sufficient to prevent repulsion between the complementary nucleic acid strands to allow Watson-Crick hydrogen bonding. In contrast, the positively-charged catalytic peptide interacted poorly with target RNA, when counter cations similarly screened the negatively-charged sugar-phosphate RNA backbones. The peptide only became the key player, when counter cations were insufficient for charge screening; moreover, only under such non-physiological conditions did conjugates form strong complexes with non-complementary RNAs. Communicated by Ramaswamy H. Sarma
In silico study of the association of the HLA-A*31:01 allele (human leucocyte antigen allele 31:01) with neuroantigenic epitopes of PLP (proteolipid protein), MBP (myelin basic protein) and MOG proteins (myelin oligodendrocyte glycoprotein) for studying the multiple sclerosis disease pathogenesis
Creators: name: Mohammadi-Milasi, Fatemeh
name: Mahnam, Karim
name: Shakhsi-Niaei, Mostafa
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The main pathologic hallmark of multiple sclerosis is a demyelinating plaque that contains a prominent immunologic response dominated by T cells of the immune system. PLP (proteolipid protein), MPB (myelin basic protein), and Myelin oligodendrocyte glycoprotein (MOG) proteins are important autoantigens for the demyelinating of CNS in multiple sclerosis. There is good evidence indicating that T CD8+ cells and MHC class I molecules play an important role in this disease. The HLA-A*31:01 allele of MHC class I is a member of HLA-A3 superfamily and there is no clear report concerning the relationship of this allele with MS. Feeling this gap, we studied the possible association of the HLA-A*31:01 with MS by prediction of neuroantigenic epitopes of human MBP, PLP, and MOG proteins of myelin sheath using in silico methods. PLP did not show any neuroantigenic epitope, but the two epitopes of MBP and seven epitopes of MOG for HLA-A*31:01 were determined via bioinformatics servers. In silico study of the nine epitope showed that MOG195-204 (LIICYNWLHR) peptide of the membrane-associated/cytoplasmic part of human MOG has suitable binding affinity to the HLA-A*31:01 allele as a potential neuroantigenic epitope. Further investigations of this peptide revealed that the binding of C-terminal residue of this peptide has a more significant effect on binding to this allele than the N-terminal part of the peptide. Altogether, this combination of “LIICYNWLHR/A*31:01 allele “may play an important role in MS pathogenesis and this complex is suggested for further studies such as T cell receptor. Communicated by Ramaswamy H. Sarma
Additional file 4 of Impact of an integrated nutrition, health, water sanitation and hygiene, psychosocial care and support intervention package delivered during the pre- and peri-conception period and/or during pregnancy and early childhood on linear growth of infants in the first two years of life, birth outcomes and nutritional status of mothers: study protocol of a factorial, individually randomized controlled trial in India
Creators: name: Taneja, Sunita
name: Ranadip Chowdhury
name: Dhabhai, Neeta
name: Mazumder, Sarmila
name: Upadhyay, Ravi
name: Sitanshi Sharma
name: Rupali Dewan
name: Mittal, Pratima
name: Chellani, Harish
name: Bahl, Rajiv
name: Maharaj Bhan
name: Bhandari, Nita
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: Additional file 4. SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents.
8Li+alpha decay of 12B and its possible astrophysical implications
Creators: name: Soic, N.
name: Cherubini, S.
name: Lattuada, M.
name: Miljanic, DJ.
name: Romano, S.
name: Spitaleri, C.
name: Zadro, M.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The 12B excitation energy spectrum has been obtained from coincidence measurements of the 9Be+7Li -> 2alpha+8Li reaction at E{0}=52 MeV. The decay of the states at excitations between 10 and 16 Mev into alpha$+8Li has been observed for the first time. Observed alpha-decay indicates possible cluster structure of the 12B excited states. The influence of these states on the cross section of the astrophysically important 8Li(alpha,n)11B and 9Be+t reactions is discussed and the results are compared with existing results.
description: accepted for publication in Europhysics Letters
Convergent Momentum-Space OPE and Bootstrap Equations in Conformal Field Theory
Creators: name: Gillioz, Marc
name: Lu, Xiaochuan
name: Luty, Markus A.
name: Mikaberidze, Guram
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: General principles of quantum field theory imply that there exists an operator product expansion (OPE) for Wightman functions in Minkowski momentum space that converges for arbitrary kinematics. This convergence is guaranteed to hold in the sense of a distribution, meaning that it holds for correlation functions smeared by smooth test functions. The conformal blocks for this OPE are conceptually extremely simple: they are products of 3-point functions. We construct the conformal blocks in 2-dimensional conformal field theory and show that the OPE in fact converges pointwise to an ordinary function in a specific kinematic region. Using microcausality, we also formulate a bootstrap equation directly in terms of momentum space Wightman functions.
description: 25 pages, 4 figures
QSOs Associated with Messier 82
Creators: name: Burbidge, E. M.
name: Burbidge, G.
name: Arp, H. C.
name: Zibetti, S.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The starburst / AGN galaxy M82 was studied by Dahlem, Weaver and Heckman using X-ray data from ROSAT and ASCA, as part of their X-ray survey of edge-on starburst galaxies. They found seventeen unresolved hard-X-ray sources around M82, in addition to its strong nuclear source, and other X-rays within the main body of M82. We have measured optical point sources at these positions, and have obtained redshifts of six candidates at the Keck I 10-m telescope, using the low-resolution imaging spectrograph (LRIS). All six are highly compact optical and X-ray objects with redshifts ranging from 0.111 to 1.086. They all show emission lines. The three with the highest redshifts are clearly QSOs. The others with lower redshifts may either be QSOs or compact emission-line galaxies. In addition to these six there are nine QSOs lying very close to M82 which were discovered many years ago. There is no difference between optical spectra of these latter QSOs, only two of which are known to be X-ray sources, and the X-ray emitting QSOs. The redshifts of all fifteen range between 0.111 and 2.05. The large number of QSOs and their apparent association with ejected matter from M82 suggest that they are physically associated with the galaxy, and have large intrinsic redshift components. If this is correct, the absolute magnitudes lie in the range -8 < M_v < -10. Also we speculate that the luminous variable X-ray source which has been detected by Chandra in the main body of M82 some 9 arcseconds from the center is another QSO in the process of ejection from the nucleus, and propose some observational tests of this hypothesis.
description: 16 pages aastex, 3 eps figures, accepted for publication on ApJ
Additional file 1 of Effects of cannabis oil extract on immune response gene expression in human small airway epithelial cells (HSAEpC): implications for chronic obstructive pulmonary disease (COPD)
Creators: name: Mamber, Stephen
name: Gurel, Volkan
name: Lins, Jeremy
name: Ferri, Fred
name: Beseme, Sarah
name: McMichael, John
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file 1: Table S1. Symbols and descriptions of respiratoryÂ genes used in pathway-focused PCR arrays.
Higgs Radiation off Bottom Quarks at the Tevatron and the LHC
Creators: name: Dittmaier, Stefan
name: Krämer, Michael
name: Spira, Michael
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Higgs-boson production in association with bottom quarks, ppbar/pp -> b bbar H + X, is one of the most important discovery channels for supersymmetric Higgs particles at the Tevatron and the LHC. We have calculated the next-to-leading order QCD corrections to the parton processes qqbar,gg -> bbbar H and present results for total cross sections and for distributions in the transverse momenta of the bottom quarks. The QCD corrections reduce the renormalization and factorization scale dependence and thus stabilize the theoretical predictions, especially when the Higgs boson is produced in association with high-pT bottom quarks. The next-to-leading order predictions for the total cross section are in reasonable numerical agreement with calculations based on bottom-quark fusion bbbar ->H.
description: 10 pages, 7 figures, LaTeX. Comments and references added, numerical results slightly corrected, conclusions unchanged
Electrocatalytic CO2 Reduction on CuZnAl based Oxide Catalysts: Tuning of the H2 /CO Ratio
Creators: name: Guzmán, Hilmar
name: Roldán, Daniela
name: Sacco, Adriano
name: Castellino, Micaela
name: Fontana, Marco
name: Russo, Nunzio
name: Hernández, Simelys
Publisher: name: Zenodo
Year: 2021
Subjects: CO2 Reduction
electrochemistry
CuZnAl based Oxide Catalyst

description: Electrochemical Reduction of CO2 (ER-CO2) is a very attractive alternative to tackle Global Warming.[1] Cu-based materials have shown increased yields of hydrocarbon and oxygenate products, while its selectivity towards CO is low.[2] Inspired by the thermocatalytic process, a traditional co-precipitation method was employed to synthesize CuZnAl-based oxide catalysts with a mesoporous structure. This CuZnAl catalyst was tested for the first time for the ER-CO2 under ambient conditions. The Physico-chemical properties of the catalysts were studied by several characterization techniques (e.g., XRD, XPS, BET, SEM, TEM) and electrochemical impedance spectroscopy at different applied-potentials to understand the role of the modification of the catalyst components during operation in the final selectivity and activity. Results revealed that adding amphoteric metal oxides like ZnO and Al2O3 to the CuO-based catalyst contributed to promote CO formation over H2. XPS measurements on the fresh samples revealed that the ternary CuZnAl catalyst presented a lower percentage (5%) of Cu0 + Cu1+ mixture on the surface than the other catalysts, being mainly constituted by Cu+2. This material reached a Faradaic efficiency towards syngas of almost 95% at -0.89 V vs. RHE. Nevertheless, the highest production rate of syngas was obtained at the most negative applied potential (⁓ 17 μmol h-1 cm-2 at -1.14 V vs. RHE).). A tunable H2/CO ratio was achieved by applying different potentials, reaching lower values by increasing applied negative potential (CO current density increased). In fact, a syngas with a H2/CO ratio of ⁓ 2 was obtained at -0.89 V vs. RHE, which is a suitable raw material for further methanol synthesis. The enhanced performance for syngas production of the developed CuZnAl catalyst is demonstrated to be attributed to its surface properties (i.e., alkalinity and the oxidation state on the surface, its lowest diffusional mass transfer resistance, its highest total pore volume, and the lowest Cu crystals size among the prepared catalysts.
On the existence of fixed points for typical nonexpansive mappings on spaces with positive curvature
Creators: name: Bargetz, Christian
name: Dymond, Michael
name: Medjic, Emir
name: Reich, Simeon
Publisher: name: arXiv
Year: 2020
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 47H09, 54E52

description: We show that the typical nonexpansive mapping on a small enough subset of a CAT($κ$)-space is a contraction in the sense of Rakotch. By typical we mean that the set of nonexpansive mapppings without this property is a $σ$-porous set and therefore also of the first Baire category. Moreover, we exhibit metric spaces where strict contractions are not dense in the space of nonexpansive mappings. In some of these cases we show that all continuous self-mappings have a fixed point nevertheless.
description: 14 pages. Accepted version of the manuscript
Laophontidae T. Scott 1905
Creators: name: Wells, J. B. J.
Publisher: name: Zenodo
Year: 2007
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Maxillopoda
Harpacticoida
Laophontidae

description: Family Laophontidae  Sexual dimorphism is highly developed in this family. Separate keys are given for males and females.
 Caution: P2–P4 setation is variable in many species. Variation is known to occur between populations, within a population, between the sexes and even between the right and left members of a pair of legs in a single individual. While these keys take present knowledge of variation into account, its very existence means that any identification must be checked against a good description.
description: Published as part of Wells, J. B. J., 2007, An annotated checklist and keys to the species of Copepoda Harpacticoida (Crustacea), pp. 1-872 in Zootaxa 1568 (1) on page 430, DOI: 10.11646/zootaxa.1568.1.1, http://zenodo.org/record/5096323
Phenotypic suppression caused by resonance with light-dark cycles indicates the presence of a 24-hours oscillator in yeast and suggests a new role of intrinsically disordered protein regions as internal mediators
Creators: name: Camponeschi, Ilaria
name: Damasco, Achille
name: Uversky, Vladimir N.
name: Giuliani, Alessandro
name: Bianchi, Michele M.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: The mutual interaction between environment and life is a main topic of biological sciences. An interesting aspect of this interaction is the existence of biological rhythms spanning all the levels of organisms from bacteria to humans. On the other hand, the existence of a coupling between external oscillatory stimuli and adaptation and evolution rate of biological systems is a still unexplored issue. Here we give the demonstration of a substantial increase of heritable phenotypic changes in yeast, an organism lacking a photoreception system, when growing at 12 h light/dark cycles, with respect to both stable dark (or light) or non-12 + 12 h cycling. The model system was a yeast strain lacking a gene whose product is at the crossroad of many different physiological regulations, so ruling out any simple explanation in terms of increase in reverse gene mutations. The abundance of intrinsically disordered protein regions (IDPRs) in both deleted gene product and in its vast ensemble of interactors supports the hypothesis that resonance with the environmental cycle might be mediated by intrinsic disorder-driven interactions of protein molecules. This result opens to the speculation of the effect of environment/biological resonance phenomena in evolution and of the role of protein intrinsically disordered regions as internal mediators. Communicated by Ramaswamy H. Sarma
Calculating adiabatic evolution of the perturbed DNLS/MNLS solitons
Creators: name: Chen, Xiang-Jun
name: Lam, Wa Kun
Publisher: name: arXiv
Year: 2004
Subjects: subject: Pattern Formation and Solitons (nlin.PS)
subject: FOS: Physical sciences

description: A symbolic computation technique is developed to calculate adiabatic evolution equations for parameters of the perturbed DNLS/MNLS solitons obtained by the recently developed direct perturbation theory [X.-J. Chen and J. Yang, Phys. Rev. E {\bf 65}, 066608(2002)]. Effects of the intrapulse Raman scattering, third-order group velocity dispersion, and narrow-banded filters with nonlinear gain on the MNLS solitons are studied as examples.
description: 10 pages, 1 figure. to be published on Phys. Lett. A
Thyroid and breast cancer in two sisters with monoallelic mutations in the ataxia telangiectasia mutated (ATM) gene - Supplemental Materials
Creators: name: Miasaki, Fabíola Yukiko
name: Saito, Kelly Cristina
name: Lopes Yamamoto, Guilherme
name: Boguszewski, César Luiz
name: Amaral de Carvalho, GIsah
name: Kopp, Peter Andreas
name: Kimura, Edna Teruko
Publisher: name: Zenodo
Year: 2021
Subjects: thyroid neoplasms
genetic predisposition to disease

description: Supplemental Materials of "Thyroid and breast cancer in two sisters with monoallelic mutations in the ataxia telangiectasia mutated (ATM) gene". This paper was submitted to JES and these supplemental materials contain two tables: variants associated with breast and thyroid cancers were extensively researched and negative data were listed in table 1. Afterward, MAF < 0.01 and CADD > 25 variants were observed in the studied exomes and listed in table 2.
description: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (PDSE - 88881.362254/2019-01) - Fabíola Yukiko Miasaki Conselho Nacional de Desenvolvimento Científico e Tecnológico (#308331/2017-6) - Edna Teruko Kimura Conselho Nacional de Desenvolvimento Científico e Tecnológico (430756/2018-6) - Edna Teruko Kimura Unrestricted Gift in Memory of Christine O'Brien - Peter A Kopp
Understanding the thermal response of rice eukaryotic transcription factor eIF4A1 towards dynamic temperature stress: insights from expression profiling and molecular dynamics simulation
Creators: name: Dhanawantari L. Singha
name: Jitendra Maharana
name: Panda, Debashis
name: Budheswar Dehury
name: Modi, Mahendra Kumar
name: Salvinder Singh
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Computational Biology

description: Eukaryotic translation initiation factors (eIFs) are the group of regulatory proteins that are involved in the initiation of translation events. Among them, eIF4A1, a member of the DEAD-box RNA helicase family, participates in a wide spectrum of activities which include, RNA splicing, ribosome biogenesis, and RNA degradation. It is well known that ATP-binding and subsequent hydrolysis activities are crucial for the functionality of such helicases. Although the stress-responsive upregulation of eIF4A1 has been reported in plants during stress, it is difficult to anticipate the functionality of the corresponding protein product. Therefore, to understand the activity of eIF4A1 in rice in response to temperature stress, we first conducted an expression analysis of the gene and further investigated the structural stability of the eIF4A1-ATP/Mg2+ complex through molecular dynamics (MD) simulations at different temperature conditions (277 K, 300 K, and 315 K). Our results demonstrated a three to fourfold increased expression of rice eIF4A1 both in root and shoot at 42 °C compared to control. Furthermore, the MD simulation portrayed strong ATP/Mg2+ binding at a higher temperature in comparison to control and cold temperature. Overall, the increased expression pattern of eIF4A1 and strong ATP/Mg2+ binding at higher temperature indicated the heat stress-tolerant capacity of the gene in rice. The results from our study will help in understanding the activity of gene and guide the researchers for screening of novel stress inducible candidate genes for the engineering of temperature stress tolerant plants. Communicated by Ramaswamy H. Sarma
Acenocoumarol’s pharmacokinetic: linear or not?
Creators: name: Kumar, Parveen
name: Kapoor, Puneet
name: , Meenu
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2019
Subjects: acenocoumarol
pharmacokinetic
linearity

description: EXCLI Journal; 18:Doc679; ISSN 1611-2156
Modeling of the Variable Circumstellar Absorption Features of WD 1145+017
Creators: name: Fortin-Archambault, M.
name: Dufour, P.
name: Xu, S.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We present an eccentric precessing gas disk model designed to study the variable circumstellar absorption features detected for WD 1145+017, a metal polluted white dwarf with an actively disintegrating asteroid around it. This model, inspired by one recently proposed by Cauley et al., calculates explicitly the gas opacity for any predetermined physical conditions in the disk, predicting the strength and shape of all absorption features, from the UV to the optical, at any given phase of the precession cycle. The successes and failures of this simple model provide valuable insight on the physical characteristics of the gas surrounding the star, notably its composition, temperature and density. This eccentric disk model also highlights the need for supplementary components, most likely circular rings, in order to explain the presence of zero velocity absorption as well as highly ionized Si IV lines. We find that a precession period of $4.6\pm0.3$ yrs can successfully reproduce the shape of the velocity profile observed at most epochs from April 2015 to January 2018, although minor discrepancies at certain times indicate that the assumed geometric configuration may not be optimal yet. Finally, we show that our model can quantitatively explain the change in morphology of the circumstellar features during transiting events.
description: 22 pages, 27 figures, submitted to The Astrophysical Journal