cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
What does the owner-manager want and get out of the business? Are family firms different?
Creators: name: Sjogren, Helena
name: Puumalainen, Kaisu
name: Syrja, Pasi
Publisher: name: Swinburne
Year: 2024

description: This paper aims to contribute to the existing knowledge of family firms and small business management. Especially in times of economic downturn small business owners have to carefully balance individual and business needs when making decisions about the extraction of profits from the company. In many circumstances the owner-managers will sacrifice their drawings in order to secure the future growth or even survival of the firm. This could be even more pronounced in small family businesses. First we show that small family firms’ owner-managers differ from other small firm owner-managers in terms of the amount and type of drawings they take from the company. Secondly, we examine the role of work values of the owner-manager as a potential link between the family involvement and drawings strategy.
title: „Was wissen Sie über Ihre Erkrankung?“ – Eine Studie zu Auswirkungen einer strukturierten Informationsveranstaltung auf Krankheitswissen und Krankheitswahrnehmung bei PatientInnen mit Granulomatose mit Polyangiitis
Creators: name: Pilz, Annika
name: Keyßer, Gernot
name: Schäfer, Christoph
name: Schmidt, Florian
name: Mattukat, Kerstin
name: Raberger, Katja
name: Wienke, Andreas
name: Zipfel, Nancy
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die Granulomatose mit Polyangiitis (GPA) stellt für die Betroffenen eine große Herausforderung dar. Für andere rheumatische Erkrankungen haben Patientenschulungen einen hohen Stellenwert. Bislang finden sich jedoch für die GPA in Deutschland kaum adäquate Schulungsprogramme.[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Dopaminergic regulation of gene expression in the neuroendocrine brain of the goldfish (Carassius auratus)
Creators: name: Popesku, Jason Theodore
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Biology, Neurobiology.
subject: Biology, Physiology.

description: Dopamine (DA) is the single most potent inhibitor of luteinizing hormone (LH) release from the fish pituitary and is fundamental to the neuroendocrine control of reproduction in vertebrates. It exerts its functions through DA D1- and D2-specific postsynaptic receptors. In order for DA to be such a potent inhibitor of reproduction, I hypothesized that DA must inhibit multiple LH-stimulatory systems in the brain. I provide the first evidence that a specific DA receptor, the D2 receptor, is alternatively spliced in fish and discuss its significance in terms of the inhibitory tone of DA. A wide-scale assessment of the genes and proteins that are under the regulatory control of DAergic action is provided and begins to elucidate mechanistic pathways that DA may be modulating and showed that D1- and D2-receptor specific agonists modulate different biochemical pathways. It is then shown that DA, acting through the D1 receptor, may be modulating the effects of another neurotransmitter, glutamate, through AMPA-type receptors. Blockage of the D1 receptor resulted in a rapid and pronounced increase of activin betaa transcription and subsequent stimulation with AMPA resulted in a significant increase in isotocin and chicken-type gonadotropin-releasing hormone, concurrently with increased circulating LH levels. The hypothalamic expression of a neuronal stem cell marker, DA cell markers and developmental factors are significantly increased in the days following injection with a specific DA neurotoxin. This provides evidence for DA neuron regeneration in the adult hypothalamus, and is indicative of an intrinsic regenerative capacity of the principle hypophysiotropic LH-inhibitory system for dynamic recovery and maintenance of function after injury. Comprehensive meta-analysis of microarray data identified 268 ESTs that are very likely to be transcriptionally-regulated by DA, indicating the major influence of DA on hypothalamic function. The hypothesis that industrial pollution (pulp and paper mill effluents) inhibits reproduction in the fathead minnow was tested by determining effects on the hypothalamic gene expression. This thesis (1) characterizes the role of DA in neuroendocrine function in fish; (2) identifies a novel mechanism of LH release mediated through DA, and; (3) demonstrates an ecologically-relevant and industrial application of the findings of this thesis.
title: Malignomrisiko erhöht bei Patienten mit Myositis-spezifischen Antikörpern: Daten der Myositis Kohorte Erlangen (MYCE)
Creators: name: Geveshausen, Sven
name: Distler, Jörg
name: Schett, Georg
name: Manger, Bernhard
name: Knitza, Johannes
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Idiopathisch inflammatorische Myopathien (IIM) sind eine heterogene Gruppe von erworbenen Erkrankungen der Skelettmuskulatur. Spezifische Antikörper stellen eine wichtige diagnostische Säule dar und gehen mit speziellen klinischen Manifestation und Risiken einher. Allerdings werden[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Outcome Definition Influences the Relationship Between Genetic Polymorphisms of ERCC1, ERCC2, SLC22A2 and Cisplatin Nephrotoxicity in Adult Testicular Cancer Patients
Creators: name: Zazuli, Zulfan
name: Otten, Leila S.
name: Drögemöller, Britt I.
name: Medeiros, Mara
name: Monzon, Jose G.
name: Wright, Galen E. B.
name: Kollmannsberger, Christian K.
name: Bedard, Philippe L.
name: Chen, Zhuo
name: Gelmon, Karen A.
name: McGoldrick, Nicole
name: Kitchlu, Abhijat
name: Vijverberg, Susanne J. H.
name: Masereeuw, Rosalinde
name: Ross, Colin J.
name: Liu, Geoffrey
name: Carleton, Bruce C.
name: Maitland-Van Der Zee, Anke H.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Although previous research identified candidate genetic polymorphisms associated with cisplatin nephrotoxicity, varying outcome definitions potentially contributed to the variability in the effect size and direction of this relationship. We selected genetic variants that have been significantly associated with cisplatin-induced nephrotoxicity in more than one published study (SLC22A2 rs316019; ERCC1 rs11615 and rs3212986; ERCC2 rs1799793 and rs13181) and performed a replication analysis to confirm associations between these genetic polymorphisms and cisplatin nephrotoxicity using various outcome definitions. We included 282 germ cell testicular cancer patients treated with cisplatin from 2009–2014, aged >17 years recruited by the Canadian Pharmacogenomics Network for Drug Safety. Nephrotoxicity was defined using four grading tools: (1) Common Terminology Criteria for Adverse Events (CTCAE) v4.03 for acute kidney injury (AKI) or CTCAE-AKI; (2) adjusted cisplatin-induced AKI; (3) elevation of serum creatinine; and (4) reduction in the estimated glomerular filtration rate (eGFR). Significant associations were only found when using the CTCAE v4.03 definition: genotype CA of the ERCC1 rs3212986 was associated with decreased risk of cisplatin nephrotoxicity (ORadj = 0.24; 95% CI:0.08–0.70; p = 0.009) compared to genotype CC. In contrast, addition of allele A at SLC22A2 rs316019 was associated with increased risk (ORadj = 4.41; 95% CI:1.96–9.88; p < 0.001) while genotype AC was associated with a higher risk of cisplatin nephrotoxicity (ORadj = 5.06; 95% CI:1.69–15.16; p = 0.004) compared to genotype CC. Our study showed that different case definitions led to variability in the genetic risk ascertainment of cisplatin nephrotoxicity. Therefore, consensus on a set of clinically relevant outcome definitions that all such studies should follow is needed.
title: Update 2020: Sicherheit und positive Auswirkungen von Hydroxychloroquin auf den Schwangerschaftsverlauf bei Frauen mit Systemischem Lupus Erythematodes
Creators: name: Haase, Isabell
name: Brinks, Ralph
name: Schneider, Matthias
name: Fischer-Betz, Rebecca
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Hydroxychloroquin (HCQ) ist beim systemischen Lupus Erythematodes (SLE) generell und insbesondere als Therapieoption während der Schwangerschaft seit Jahren etabliert. Kürzlich wurden die positiven Auswirkungen und die Sicherheit von HCQ angesichts einer geänderten Fachinformation[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Towards Sustainable Development Goals: Working Paper
Creators: name: Görlach, Benjamin
name: McFarland, Keighley
Publisher: name: My University
Year: 2014
Subjects: subject: Vereinte Nationen
subject: UNCED
subject: Vertragsstaatenkonferenz
subject: environmental sustainability
subject: quality goals
subject: Nachhaltigkeit | Strategien | Internationales
subject: Sustainability | Strategies | International matters

description: This report first describes the two processes for the development of SDGs and the post-2015 development agenda, and the options to integrate the results of both processes in order to arrive at one set of goals. It goes on to discuss the possible structure of a set of SDGs, and discusses a number of topic clusters, as an illustration of what possible SDGs could look like.
Quelle: www.umweltbundesamt.de
description: This report first describes the two processes for the development of SDGs and the post-2015 development agenda, and the options to integrate the results of both processes in order to arrive at one set of goals. It goes on to discuss the possible structure of a set of SDGs, and discusses a number of topic clusters, as an illustration of what possible SDGs could look like.
Aboriginals, colonists and multiculturalism: the dialectic of recognition and social exclusion in Australian history
Creators: name: Gare, Arran
Publisher: name: Swinburne
Year: 2024

description: Developing Hegel's ideas on the dialectic of recognition and its role in the evolution of civilization, Charles Taylor in a seminal work, Multiculturalism and the 'Politics of Recognition' (since translated into Italian, French and German), characterized multiculturalism, in which different cultures within a country are recognized and respected, as a new phase in ethical and political development (Taylor and Gutmann, 1992; Taylor, 1994). Australia is unique in modern history in the extent to which it embraced multiculturalism and abandoned nationalism the commitment to a territorial community the membership of which is defined first and foremost in terms of place of birth. It appears to be a post-nationalist, multicultural society that celebrates its cultural diversity. Far from being social outcastes, immigrants, who are selected for their level of education, have a higher average income than native born Australians. Australia, therefore, might seem to provide a vision of the future for those countries striving to overcome the exclusionary tendencies of their nationalist heritage. [Introduction]
Anomalous temperature dependence of diode saturation currents in polycrystalline silicon thin-film solar cells on glass
Creators: name: Wong, J.
name: Huang, J. L.
name: Kunz, O.
name: Ouyang, Z.
name: He, S.
name: Widenborg, P. I.
name: Aberle, A. G.
name: Keevers, M.
name: Green, M. A.
Publisher: name: Swinburne
Year: 2024

description: Temperature dependent Suns-Voc measurements are performed on four types of polycrystalline silicon thin-film solar cells on glass substrates, all of which are made by solid phase crystallization∕epitaxy of amorphous silicon from plasma enhanced chemical vapor deposition or e-beam evaporation. Under the two-diode model, the diode saturation currents corresponding to n = 1 recombination processes for these polycrystalline silicon p‐n junction cells follow an Arrhenius law with activation energies about 0.15-0.18 eV lower than that of single-crystal silicon p‐n diodes of 1.206 eV, regardless of whether the cells have an n- or p-type base. This discrepancy manifests itself unambiguously in a reduced temperature sensitivity of the open-circuit voltage in thin-film polycrystalline silicon solar cells compared to single-crystal silicon cells with similar voltages. The physical origin of the lowered activation energy is attributed to subgap levels acting either as minority carrier traps or shallow recombination centers.
DEP Bulletin - 2022 - Volume 46 Issue 18
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 2022

description: The DEP bulletin is a semi-monthly publication of the New Jersey Department of Environmental Protection. It contains a list of construction permit applications recently filed or acted upon by the Department along with a calendar of events of interest, a schedule of public hearings, and Environmental Impact Statements acted upon during the period.
Cannabis use as a risk factor for causing motor vehicle crashes : a prospective study
Creators: name: Brubacher, Jeffrey
name: Chan, Herbert
name: Erdelyi, Shannon
name: Macdonald, Scott
name: Asbridge, Mark
name: Mann, Robert E.
name: Eppler, Jeffrey
name: Lund, Adam
name: MacPherson, Andrew
name: Martz, Walter
name: Schreiber, William Edward, 1954-
name: Brant, Rollin
name: Purssell, Roy
Publisher: name: Wiley
Year: 2022

description: Aim We conducted a responsibility analysis to determine whether drivers injured in motor vehicle collisions who test positive for Δ-9-tetrahydrocannabinol (THC) or other drugs are more likely to have contributed to the crash than those who test negative. Design Prospective case–control study. Setting Trauma centres in British Columbia, Canada. Participants Injured drivers who required blood tests for clinical purposes following a motor vehicle collision. Measurements Excess whole blood remaining after clinical use was obtained and broad-spectrum toxicology testing performed. The analysis quantified alcohol and THC and gave semiquantitative levels of other impairing drugs and medications. Police crash reports were analysed to determine which drivers contributed to the crash (responsible) and which were ‘innocently involved’ (non-responsible). We used unconditional logistic regression to determine the likelihood (odds ratio: OR) of crash responsibility in drivers with 0 < THC < 2 ng/ml, 2 ng/ml ≤ THC < 5 ng/ml and THC ≥ 5 ng/ml (all versus THC = 0 ng/ml). Risk estimates were adjusted for age, sex and presence of other impairing substances. Findings We obtained toxicology results on 3005 injured drivers and police reports on 2318. Alcohol was detected in 14.4% of drivers, THC in 8.3%, other drugs in 8.9% and sedating medications in 19.8%. There was no increased risk of crash responsibility in drivers with THC < 2 ng/ml or 2 ≤ THC < 5 ng/ml. In drivers with THC ≥ 5 ng/ml, the adjusted OR was 1.74 [95% confidence interval (CI) = 0.59–6.36; P = 0.35]. There was significantly increased risk of crash responsibility in drivers with blood alcohol concentration (BAC) ≥ 0.08% (OR = 6.00;95% CI = 3.87–9.75; P < 0.01), other recreational drugs detected (OR = 1.82;95% CI = 1.21–2.80; P < 0.01) or sedating medications detected (OR = 1.45; 95%CI = 1.11–1.91; P < 0.01). Conclusions In this sample of non-fatally injured motor vehicle drivers in British Columbia, Canada, there was no evidence of increased crash risk in drivers with Δ-9-tetrahydrocannabinol < 5 ng/ml and a statistically non-significant increased risk of crash responsibility (odds ratio = 1.74) in drivers with Δ-9- tetrahydrocannabinol ≥ 5 ng/ml.
Aufbereitung von gescannten Röntgenbildern zur filmlosen Diagnostik
Creators: name: Kehrer, Jürgen
name: Schulthess, Peter
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: DDC 004 / Data processing & computer science
subject: Image transmission
subject: Radiography
subject: Bildübertragung
subject: Röntgendiagnostik

description: Ziel dieses Projektes ist die Übertragung von Röntgenbildern von einer zentralen Stelle, an der die Bilder digitalisiert und gespeichert werden, zu entfernten Empfangsstationen. Um die Transferdauer zu verkürzen und für die Archivierung auf CD-R werden die Bilder komprimiert. Als Übertragungsmedium zwischen den Kliniken kommt sowohl ISDN als auch ETHERNET in Frage. Die (erste) Befundung der Röntgenbilder soll am Bildschirm stattfmden. Die Originale der Röntgenfilme werden in den meisten Fällen zur Diagnosestellung nicht mehr benötigt. Soweit die Theorie. Leider treten bei der Digitalisierung und Komprimierung Qualitätseinbußen auf. Diese lassen sich aber durch geeignete Scanner-Hardware, Justierung und Algorithmen klein halten. Ein größeres Problem stellt das Ausgabemedium Bildschirm dar. Ein Standardbildschirm kann nur 256 verschiedene Graustufen anzeigen. Ein Röntgenfilm besitzt aber einen Grauwertumfang von mehr als 700 Graustufen. Das Problem besteht nun darin, diese 700 Graustufen auf die 256 Graustufen des Bildschirms abzubilden. Die einfachste Möglichkeit ist die interaktive Einstellung von Helligkeit und Kontrast (window and center control) für das gesamte Bild oder auch nur für einen Bildausschnitt. Die Histogrammequalisierung (HE) liefert diese Einstellung für Bilder mit eingeschränktem Grauwertbereich automatisch. Die besten Ergebnisse erzielt man mit der adaptiven Histogramm-Equalisierung (AHE) zur Reduktion der 700 Grauwerte. Durch Segmentierung des Bildes in viele kleine Bereiche, für die jeweils eine eigene Transferfunktion berechnet wird, erreicht man eine globale Reduzierung der Grauwerte ohne große Verluste an Grauwertauflösung in den einzelnen Bereichen.
title: Autoantikörper gegen GPCR, Wachstumsfaktoren und Wachstumsfaktorrezeptoren sind mit Erkrankungsmanifestationen der Systemischen Sklerose assoziiert
Creators: name: Sterner, Kristina
name: Heidecke, Harald
name: Busch, Hauke
name: Müller, Antje
name: Dalmann, Anja
name: Riemekasten, Gabriela
name: Schinke, Susanne
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die Morbidität und die Mortalität der systemischen Sklerose (SSc) werden maßgeblich durch die Vaskulopathie wie die akrale Perfusionsstörung und pulmonal-arterielle Hypertonie (PAH) sowie Herz- und Lungenbeteiligung bestimmt. Die Werte der Autoantikörper (AK) gegen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Incorporating risk communication into business management education
Creators: name: Galloway, Chris
name: Kwansah-Aidoo, Kwamena
Publisher: name: Swinburne
Year: 2024

description: In a turbulent world, business managers increasingly see risk management as a central concern---especially as some familiar risks take on more extreme, 'hyper-risk' forms. Risk management should therefore be a core theme in business management education. Yet tertiary curricula do not typically reflect this importance. Where risk management is studied, it is usually in specialized academic 'silos', such as a course on derivatives and risk. Even less attention is devoted to risk communication as a vital sub-discipline of risk management. Risk communication can help to avert an organizational crisis by lowering the risk to organisations from stakeholder-driven social conflict. It can also help devolve responsibility for risk mitigation by enabling individuals, groups and communities to take appropriate steps to minimize the likelihood that given risks will materialize in actual harm. This paper explores how both risk management and risk communication could be introduced into business management curricula. It then examines risk communication as a particular case, discussing approaches educators could use to teach both its theory and its practice.
Functional Remodelling of the Nucleolus by Long Noncoding RNA
Creators: name: Jacob, Mathieu
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Tumour microenvironment
Noncoding RNA
Nucleolus

description: The nucleolus is a plurifunctional organelle in which structure and function are intimately linked. Though it is primarily known as the site of ribosomal biogenesis, the nucleolus is also capable of orchestrating the immobilization of a broad range of proteins under specific environmental conditions. This process, known as nucleolar sequestration, contributes to cell viability under stress. Despite the importance of this post-translational regulatory pathway, very little is known about the mechanisms that govern it. Here, we show that heat shock and acidosis, two physiological stimuli associated with nucleolar sequestration, induce the expression of long noncoding RNA (lncRNA) from stimulus-specific loci of the ribosomal intergenic spacer (IGS). These lncRNAs, in turn, immobilize proteins encoding a nucleolar detention sequence (NoDS) within a compartment of the nucleolus termed the detention centre (DC). The DC is a spatially and dynamically distinct region, characterized by an 8-anilino-1-naphthalenesulfonate (ANS)-positive hydrophobic signature. Its formation is accompanied by a redistribution of nucleolar factors and an arrest in ribosomal biogenesis. Silencing of regulatory IGS lncRNA prevents the creation of this structure and allows the nucleolus to retain its tripartite organization and transcriptional activity. Signal termination causes a decrease in IGS transcript levels and a return to the active nucleolar conformation. We propose that the induction of IGS lncRNA, by environmental signals, operates as a molecular switch that regulates the structure and function of the nucleolus.
title: Belimumab ist wirksam und reduziert die Antikörperlast bei einer Patientin mit einem dreifach Antikörper-positiven Antiphospholipid-Syndrom
Creators: name: Klemm, Philipp
name: Tarner, Ingo
name: Müller-Ladner, Ulf
name: Lange, Uwe
name: Hudowenz, Ole
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Belimumab, als Inhibitor des B-Zell aktivierenden Faktors (BAFF), ist bislang das einzig zugelassene Biologikum beim systemischen Lupus erythematodes (SLE). Eine Therapie mit Belimumab hat neben der klinischen Wirkung auch Einfluss auf die Höhe der Autoantikörper. So werden sowohl[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Using Multiple Regression Analyses to Uncover Patterns of Correlates of Grief Problems, Depression and Suicidal Ideation Among Suicide Bereaved Individuals
Creators: name: Feigelman, William
name: Cerel, Julie
name: Sheehan, Lindsay
name: Oexle, Nathalie
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: suicide loss
subject: grief difficulties
subject: depression
subject: suicidal ideation
subject: personal growth
subject: DDC 150 / Psychology
subject: DDC 300 / Social sciences

description: This analysis of a convenience sample survey of 195 suicide bereaved adults focuses on predictors of three important highly interrelated experiences among the suicide bereaved: grief problems, depression and suicidal thinking. Although each of these three experiences can be explained by a unique set of predictors, they share many commonalities. Several predictors stood out especially in either aggravating or alleviating these experiences: personal (or post-traumatic) growth, perceived social support, feelings of blameworthiness, perceived suicide stigma, years since loss and a respondent’s mental health difficulties experienced prior to their suicide loss. We also review the clinical implications of these results.
title: Niedrig dosierte Acetylsalicylsäure zur Vorbeugung von Präeklampsien bei SLE-Patientinnen – präkonzeptionelle Beratung führt zu optimiertem Einsatz
Creators: name: Haase, Isabell
name: Brinks, Ralph
name: Schneider, Matthias
name: Fischer-Betz, Rebecca
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Das Risiko einer Präeklampsie ist in Schwangerschaften bei Frauen mit Autoimmunerkrankungen wie dem systemischen Lupus erythematodes erhöht, besonders wenn weitere Risikofaktoren (z.B. Hypertonie, Nierenerkrankung, Antiphospholipidantikörper (aPL)) vorliegen. In der Normalbevölkerung[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
title: Prospective Use of the Glucocorticoid Toxicity Index (GTI) in a Cohort of Vasculitis Patients
Creators: name: Ehlers, Lisa
name: Wiebe, Edgar
name: Freier, Desirée
name: Hermann, Sandra
name: Zhang, Yuqing Q
name: Buttgereit, Frank
name: Stone, John H
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: The Glucocorticoid Toxicity Index (GTI) app measures changes in glucocorticoid-associated morbidity [ref:1]. The GTI, which captures improvement as well as worsening in glucocorticoid (GC) toxicity, consists of two subscores. The Cumulative Worsening Score (CWS) only counts toxicities[for full text, please go to the a.m. URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Progressive collapse analysis of reinforced concrete buildings under blast loadings
Creators: name: Mirhosseini, Sahar
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Engineering, Civil.

description: During the last two decades, a significant number of embassies, commercial centers, governmental structures, industrial facilities, and residential buildings have been attacked by explosives. Consequently, blast-resistant design of structures has gained importance in recent years to minimize structural damage and threat to life safety. Some guidelines have been developed for this purpose, based on previously conducted research. The U.S. General Services Administration (GSA) report is one of these guidelines that provide practical solutions to blast-related engineering problems, including requirements for analysis and design for prevention of progressive collapse in structures. The guidelines also help establish the potentials for progressive collapse in existing buildings. Three multi-storey reinforced concrete frame buildings were considered in the current research project to investigate their vulnerability against blast-triggered progressive collapse. Computer software DRAIN R/C was employed for modeling and structural analysis of buildings. Among the parameters considered was building height (or number of stories). This was done by considering a 5-storey and a 10-storey R/C building with 6m span length in each bay. In addition, the effect of span length on progressive collapse was investigated by considering a 5-storey building with 6m and 9m spans. All buildings consisted of a symmetrical floor plan and moment resisting frames. Two types of analysis were conducted under gravity loads according to the GSA report specifications, (i) elastic analysis; where the members were assumed to remain elastic by specifying an unrealistically high moment capacity and (ii) inelastic analysis; where the members were allowed to yield shortly before reaching their nominal (design) capacities. The analyses were conducted by removing a first-storey column and investigating the consequential increase in force and deformation demands in adjacent members. The results from linear analysis indicate that the loss of a corner column may not necessarily trigger progressive collapse, while the removal of an exterior edge column and interior column would result in structural collapses. Results from nonlinear analysis indicate total collapse of all the buildings if the total load of 2(DL + 0.25LL) is applied. But if the loading is reduced to (DL + 0.5LL), the collapse occurs only in a building with an interior first-storey column removed.
title: Prädiktoren einer Remission bei ANCA-assoziierten Vaskulitiden im Langzeitverlauf
Creators: name: Oelzner, Peter
name: Wegmann, Felix
name: Pfeil, Alexander
name: Busch, Martin
name: Wolf, Gunter
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die Effektivität der Therapie von ANCA-assoziierten Vaskulitiden (AAV) hat sich seit Einführung der auf dem Vorliegen von Organ- und lebensbedrohenden Manifestationen basierenden Differenzialtherapie wesentlich verbessert. Das Ziel unserer Studie bestand darin, Remissionshäufigkeit[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Crowding with negatively conditioned flankers and targets
Creators: name: Pittino, Ferdinand Mathias Werner
name: Eberhardt, Lisa Valentina
name: Kurz, Anja
name: Huckauf, Anke
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: Critical spacing
subject: Evaluative conditioning
subject: DDC 150 / Psychology
subject: Crowding
subject: Emotions
subject: Crowding
subject: Gefühl

description: Crowding refers to the phenomenon of increased difficulty in identifying a peripherally presented stimulus when it is surrounded by adjacent flankers compared to when it is presented in isolation. The aim of the present study was to investigate the influence of flanker and target emotion on crowding effects. Therefore, Landolt rings with certain opening directions were conditioned with neutral or negative pictures. These conditioned stimuli were afterwards used in a visual crowding task, in which the critical spacing (75% threshold) was assessed for emotional flankers as well as for emotional targets. Larger crowding effects were observed for negatively relative to neutrally conditioned flankers, indicating more interference with negative flankers. Additionally, for participants showing a strong evaluative conditioning effect, smaller crowding effects were found for negatively relative to neutrally conditioned targets, indicating enhanced identification of negative target stimuli. In conclusion, crowding effects are modulated by both flanker and target emotion, suggesting that high-level stimulus features survive crowding and influence recognition performance. The study further shows that evaluative conditioning can be a useful tool to study the effect of emotion on rather early perceptual processes.
title: Unterschiede in Outcome und Histologie zwischen verschiedenen Subtypen der ANCA-Vasculitis
Creators: name: Mosberger, Sebastian
name: Porubsky, Stefan
name: Bergner, Raoul
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: In Studien zum Thema ANCA-Vaskulitiden werden diese häufig als eine gesamte Krankheitsentität zusammengefasst, untersucht und therapiert, wobei nicht näher auf die einzelnen Subtypen Granulomatose mit Polyangiitis (GPA), Mikroskopische Polyangiitis (MPA) oder eine isolierte[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Investigation of nonthermal plasma jet excitation mode and optical assessment of its electron concentration
Creators: name: Ivankov, Anton S.
name: Kozhevnikova, Anastasia M.
name: Schitz, Dmitry V.
name: Alekseenko, Igor V.
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: bio-medicine application
subject: cold gas-discharge plasma
subject: digital holography
subject: digital holographic interferometry
subject: DDC 530 / Physics
subject: DDC 610 / Medicine & health
subject: Plasma jets
subject: Plasma diagnostics
subject: Plasmadiagnostik

description: The results of a study of a plasma jet of atmospheric-pressure helium driven by a capacitive discharge using sine and pulsed modes of excitation are presented. The homogeneous discharge of a multi-channel plasma jet at gas temperature of 34 °C and helium flow rate of 0.5 L/min was achieved with short pulse excitation. A digital holography method is proposed to estimate a basic plasma parameter, i.e., its electron concentration. An automated digital holographic interferometry set-up for the observation and study of a nonthermal plasma jet in a pulse mode is developed and described. The synchronization features of recording devices with the generation of plasma pulses are considered. The electron concentration of the plasma jet is also estimated. The disadvantages of the proposed technique and its further application are discussed.
Sequential and Localized Implicit Wavelet Based Solvers for Stiff Partial Differential Equations
Creators: name: McLaren, Donald Alexander
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: wavelet
implicit
multi-scale
pde

description: This thesis explains and tests a wavelet based implicit numerical method for the solving of partial differential equations. Intended for problems with localized small-scale interactions, the method exploits the form of the wavelet decomposition to divide the implicit system created by the time discretization into multiple, smaller, systems that can be solved sequentially. Included are tests of this method on linear and non-linear problems, with both its results and the time required to calculate them compared to basic models. It was found that the method requires less computational effort than the high resolution control results. Furthermore, the method showed convergence towards high resolution control results.
title: Der Mainzer Lupus Score (MLS) – ein neuer Fragebogen zur Behandlung von Systemischem Lupus erythematodes
Creators: name: Hoschek, Jessica
name: Dreher, Matthias
name: Boedecker, Simone Cosima
name: Weinmann-Menke, Julia
name: Schwarting, Andreas
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Für die Diagnostik und Therapie des systemischen Lupus erythematodes (SLE) sind diverse Scores und Indizes existent. Die subjektive Sicht des Patienten fließt derzeit jedoch bei keinem der etablierten Aktivitätsscores (SLEDAI oder BILAG) mit ein. Darüber hinaus ist der[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
The 'lessons' of entrepreneurial experience: toward identifying critical development 'lessons'
Creators: name: Krueger, Norris
name: Kickul, Jill
name: Neergaard, Helle
Publisher: name: Swinburne
Year: 2024

description: This paper uses insights from cognitive developmental psychology, constructivism and social neuroscience to move beyond entrepreneurial intentions to explore deeply-held beliefs associated with entrepreneurial thinking. From those insights, we propose identifying those developmental experiences ('lessons') that are the sources of those critical deep beliefs that are intrinsic to our mental models regarding entrepreneurship: How we construct opportunities and, perhaps more important, how we learn to perceive ourselves as entrepreneurs. This paper addresses the nature of beliefs from a social neuroscience perspective, the constructivist learning model, theory and recent evidence from cognitive developmental psychology, and a look at a key phenomenon that reflects deep entrepreneurial beliefs, entrepreneurial role identity.
Mesenchymal stromal cell differentiation into osteoblasts on modular artificial proteins with bioactive ligands
Creators: name: Malouf, Diana
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Engineering, Chemical.

description: Modular self-assembling de novo triblock proteins (designated CRC) that contain a central bioactive domain with associating ends allowing preferential formation bundles have been developed. These proteins subsequently self assemble into hydrogel networks. The modularity of these triblock systems allows for different combinations of end and centre domains to modulate cell differentiation and phenotypic changes. In this study, we examined the effect of CRC peptides with bioactive ligands from extracellular matrix proteins involved in differentiation and repair activities, fibronectin (RGDS) and laminin (LQVQ), on mesenchymal stromal cell (MSC) differentiation into osteoblasts. Briefly, CRCs were covalently surface grafted onto collagen scaffolds via 1-ethyl-3(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) chemistry. Four peptide combinations tested were: P-CRC, P-CRC-RGDS/CRC, P-CRC-LQVQ/CRC and CRC-RGDS/CRC-LQVQ. They were examined for effects on proliferation and differentiation of MSCs in culture. No significant differences in proliferation rates were observed amongst samples. MSCs grown on CRC alone were unhealthy. All cells cultured on the peptide substrates, except for a combination of CRC-RGDS/CRC-LQVQ, had calcium deposits that were indicators of osteogenic differentiation. Cells grown on CRC/CRC-RGDS substrates showed most differentiation. The combination of RGDS/LQVQ peptides appeared to promote retention of an undifferentiated progenitor cell state. We have therefore shown that modular, self-assembling peptides have the potential to be useful in modulating differentiation or retention of the stem cell phenotype. With further development, they could possibly be used to develop or enhance biomaterials scaffolds for use in modulating stem cell behaviour in potential therapeutic applications.
Design of a 2 × 4 Hybrid MMI-MZI Configuration with MMI Phase-Shifters
Creators: name: Niraula, Boris B.
name: Rizal, Conrad
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: This paper reports design of a 2 × 4 hybrid multimode interferometer-Mach-zehnder interferometer (MMI-MZI) configuration consiting of compact thermo-optical switches on the silicon-on-insulator (SOI) platform. The device consists of two identical MMI slab waveguides as power splitters and couplers that are connected with two identical MMI-based phase shifters, and linear tapers at both ends of the MMIs to minimize the power coupling loss. A thin Al pad is used as a heating element and a trench is created around this pad to prevent heat from spreading, and to minimize loss. The calculated average thermo-optical switching power consumption, excess loss, and power imbalance are 1.4 mW, 0.9 dB, and 0.1 dB, respectively. The overall footprint of the device is 6 × 304 μm². The new heating method has advantages of compact size, ease of fabrication on SOI platform with the current CMOS technology, and offers low excess loss and power consumption as demanded by devices based on SOI technology. The device can act as two independent optical switches in one device.
Luftqualität 2015
Creators: name: Dauert, Ute
name: Feigenspan, Stefan
name: Himpel, Thomas
name: Minkos, Andrea
name: Schütze, Gudrun
name: Kissinger, Susan
Publisher: name: My University
Year: 2016
Subjects: subject: Luftgüte
subject: Immissionsbelastung
subject: Feinstaubbelastung
subject: Troposphärisches Ozon
subject: Luftqualität
subject: Luftschadstoff-Emissionen
subject: Luftschadstoffbelastung
subject: Luftbelastung
subject: Stickstoffdioxidbelastung
subject: Bodennahes Ozon
subject: Luft

description: Diese Auswertung der Luftqualität im Jahr 2015 in Deutschland basiert auf vorläufigen, noch nicht abschließend geprüften Daten aus den Luftmessnetzen der Bundesländer und des Umweltbundesamtes, Stand 20.01.2016. Aufgrund der umfangreichen Qualitätssicherung in den Messnetzen stehen die endgültigen Daten erst Mitte 2016 zur Verfügung. Die jetzt vorliegenden Daten lassen aber eine generelle Einschätzung des vergangenen Jahres zu. Betrachtet werden die Schadstoffe Feinstaub (PM10 und PM2,5), Stickstoffdioxid (NO2) sowie Ozon (O3), da bei diesen nach wie vor Überschreitungen der geltenden Grenzund Zielwerte zum Schutz der menschlichen Gesundheit auftreten.
title: Statusbericht des GeVas Registers: Gemeinsames Vaskulitis Register im deutschsprachigen Raum zur prospektiven Auswertung des Langzeitverlaufs von Vaskulitis-Patienten
Creators: name: Wallmeier, Pia
name: Iking-Konert, Christof
name: Adler, Sabine
name: De Groot, Kirsten
name: Hellmich, Bernhard
name: Hoyer, Bimba F.
name: Ihorst, Gabriele
name: Kaufmann, Magrit
name: Magnus, Tim
name: Müller-Ladner, Ulf
name: Rech, Jürgen
name: Schulze-Koops, Hendrik
name: Venhoff, Nils
name: Villiger, Peter
name: Schubach, Fabian
name: Lamprecht, Peter
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Ziel des Gemeinsamen Vaskulitis Registers im deutschsprachigen Raum (GeVas) ist es, alle Patienten mit einer neu diagnostizierten Vaskulitis oder einer Therapieumstellung bei einem Rezidiv in einem prospektiven, multizentrischen und pseudonymisierten Register zu erfassen und so den Langzeitverlauf[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
title: Verbesserung der Fatigue bei Patienten mit primärem Sjögren-Syndrom durch Behandlung eines SAS mittels CPAP
Creators: name: Seng, Magdalena
name: Frye, Björn Christian
name: Vollmer, Lydia
name: Voll, Reinhard
name: Finzel, Stephanie
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die Fatigue ist eine häufige und schwer zu behandelnde Begleiterscheinung des primären Sjögren Syndrom (pSS). In früheren Studien konnte gezeigt werden, dass ein Schlafapnoe Syndrom (SAS) nicht selten mit dem Vorhandensein einer Fatigue bei pSS-Patienten korreliert (Jülich[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
The dynamics of persistent organic pollutants in air and in selected lakes of the Canadian Rocky Mountains.
Creators: name: Wilkinson, Andrew Charles.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Physics, Atmospheric Science.

description: This thesis examines the concentrations of persistent organic pollutants (POPs) in air and in selected lakes of the Canadian Rocky Mountains. Water was sampled from seven lakes spanning an elevation of 1430 meters from the Interior Plains to the Western Range of the Canadian Rocky Mountains. Air samples were taken at four of these sites, encompassing an altitudinal gradient of 1205 meters. Air and water samples were used to determine net air-water gas exchange fluxes of six POPs at these four sites. This study revealed that air and water concentrations of several persistent organic pollutants did not change significantly with elevation. However, spring pulses of hexachlorocyclohexanes (HCHs) in the lakes were found to coincide with snowmelt, and concentrations of POPs were highest at Bow Lake during the year with the highest snow pack. It was observed that temperature differences with altitude had little impact on the magnitude and direction of air-water gas exchange, indicating net fluxes of POPs were most sensitive to fluctuations in relative air and water concentrations. Air-water gas exchange was compared with the total lake inventory and with estimated losses by outflow. In general, it was revealed that deposition by air-water gas exchanges was an important source of POPs with lower Henry's law constants, such as alpha and gamma-HCH, and net volatilisation was an important loss for the compounds with higher Henry's law constants, (e.g. hexachlorobenzene (HCB) and dieldrin).
title: Rate of relapse in giant cell arteritis patients after tocilizumab therapy was stopped – the Munich GCA patient cohort
Creators: name: Murray, Antoine
name: Lutz, Friederike
name: Skapenko, Alla
name: Schulze-Koops, Hendrick
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: Tocilizumab (TCZ) subcutaneously (SC) administered has been licensed in Germany since 2017 following the results of the GiACTA study for the treatment of giant cell arteritis (GCA) and thus is an alternative therapy option to long-term glucocorticoids (GC) and other immunosuppressive treatments.[for full text, please go to the a.m. URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
title: „Man lernt nie aus“ – eine Studie zur Auswirkung einer krankheitsspezifischen Informationsveranstaltung auf Krankheitswissen von Patienten mit systemischen Lupus erythematodes (SLE)
Creators: name: Schmidt, Florian
name: Pilz, Annika
name: Wienke, Andreas
name: Mattukat, Kerstin
name: Raberger, Katja
name: Keyßer, Gernot
name: Zipfel, Nancy
name: Schäfer, Christoph
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Der SLE stellt als komplexe Systemerkrankung viele Patienten vor große Herausforderungen. Etablierte Schulungsprogramme fehlen. Ziel unserer prospektiven, randomisierten, kontrollierten Studie ist es, den Einfluss einer strukturierte Informationsveranstaltung auf das Krankheitswissen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)