cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 2: Figure S3. of Reduced suppressive effect of β2-adrenoceptor agonist on fibrocyte function in severe asthma
Creators: name: Lo, Chun-Yu
name: Michaeloudes, Charalambos
name: Bhavsar, Pankaj
name: Chien-Da Huang
name: Po-Jui Chang
name: Wang, Chun-Hua
name: Han-Pin Kuo
name: Chung, Kian
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: 60506 Virology

description: Number of fibrocytes and differentiating fibrocytes in NANT cells after culture in the absence or presence of salmeterol. The number of fibrocytes (% Col I+/CD45+; A) and differentiating fibrocytes (% α-SMA+; B) within the NANT cell population, were determined in the NANT cells from healthy subjects (n = 8–9) and patients with non-severe (n = 7) or severe asthma (n = 7–9) at day 0 (0 d) or after 3 days (3 d) in the absence or presence of salmeterol (10−9- 10−7 M). Data points represent mean ± SEM. * p
Critical zeros of Hecke L-functions
Creators: name: Cantillo, Jorge
Publisher: name: No Publisher Supplied
Year: 2014

description: In this dissertation, we established that in average taken over the family of all Hecke  L-functions of weight k of size  K associated with the full modular group, at least 35% of  their zeros lie on the critical line as K → ∞. We used Levinson’s method employing a  mollifier of length K;2θ with θ sufficiently close to 1/2. To handle such a long mollifier, it  was necessary to develop an Asymptotic Large Sieve that evaluated a bilinear form by  taking advantage of sum cancellations resulting from the quasi-orthogonality property  of Hecke eigenvalues for a sufficiently large number of weights k
Ardeadoris angustolutea
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Ardeadoris
Ardeadoris angustolutea

description: Ardeadoris angustolutea (Rudman, 1990)
(Figure 3 E)
Material examined. Three specimens. MB28-004705, ZDRS, 0 6 Aug. 2013, 32m, 12mm; MB28-0 0 4877, NHR, 29 May 2014, 7m, 10mm; MHN-YT1310, NFA, 22 Jun. 2014, 20m, 6mm.
Habitats. Subtropical rocky reefs tropical coral reefs.
Occurrences. Zavora and Nuarro.
Geographic distribution. Indo-west Pacific. Marshall Islands, Samoa, Japan, Papua New Guinea (Gosliner et al. 2008), Philippines, Australia (Rudman 1990), Thailand (Gosliner et al. 2008), Réunion (Oulia 2010), Mauritius (Darnis 2009), Madagascar (Rassat 2014) and Mozambique.
Remarks. Species shows rhythmic movement of the gill branches.
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on page 15, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Fluid mechanics of functionality of anti-HIV microbicides
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Recent reports (UNAIDS, 2006) clearly demonstrate that the global HIV/AIDS epidemic presents no sign of abating; it continues to spread at a rate of 15,000 new infections every day. Today, about 42 million people live with HIV/AIDS worldwide. Among them, 25 million live in sub-Saharan Africa. In Kenya, for instance, about 2.2 million people (15% of the population) are infected with HIV. As the epidemic spreads, it is infecting more and more women; globally, it is estimated that women represent approximately 65% of all those infected with HIV/AIDS. In fact, the leading risk factor for HIV among women in much of the world is to be the monogamous wife of an unfaithful or polygamous husband. AIDS has now become one of the most serious women’s health issues globally and existing prevention methods for women at risk for HIV/AIDS are severely inadequate. Anti-HIV Microbicidal Formulations (microbicides) are a new class of products under development for prevention of HIV transmission at the sites where transmission can occur during/after intercourse. Conservative estimates are that introduction of even a partially effective microbicide could result in 2.5 million averted cases of AIDS over three years. There are now 29 microbicides under development—but none are yet on the market. Although there has been much attention to microbicides, virtually all research and development is on the active ingredients, not on the fluid delivery systems for those ingredients —i.e. the microbicide formulations (vehicles) applied by a user before sexual activity. But the vehicles are crucial: they must distribute the active ingredients to intercept HIV at all locations where it can be transmitted. Our goal is to contribute to the process of design of microbicide vehicles. We will develop a practical mathematical model of the flow of microbicidal vehicles, which can be used to study the tradeoffs in the design parameters for the microbicide vehicle, and how these affect the coating of the vulnerable vaginal surface. This relates to the level of protection of the user. The model will be applicable to microbicide vehicles now being formulated. It will be validated with experimental work of our collaborator, Prof. Katz of Duke University, whose work is funded by the NIH. We will consider how these tradeoffs interface with acceptability studies, with the advice of our collaborator Dr. Bethany Young Holt. Our efforts will produce new understanding of coating that includes both the initial distribution of vehicles after application, and also the possible changes in that coating distribution over time, as the user engages in sexual activity. For example, the coating could be dissolved or eroded away. This information will be of direct practical utility to microbicide product developers, in their efforts at effective prevention of HIV transmission.
Rhopalophora (Ischionodonta) smaragdina Martins & Napp 1989
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Rhopalophora
Rhopalophora smaragdina

description: 23. Rhopalophora (Ischionodonta) smaragdina Martins & Napp, 1989: 63 Holotype, male
Type locality. Brazil, Espírito Santo: Itapina, 18-23.XII.1967, C. Elias Current name. Ischionodonta smaragdina (Martins & Napp, 1989)
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 344, DOI: 10.5281/zenodo.250291
Atomic scale engineering of topological materials
Creators: name: Brahlek, Matthew J.
Publisher: name: No Publisher Supplied
Year: 2014

description: This dissertation seeks to understand the novel physical properties of a new class of materials called topological insulators (TIs) from an experimental standpoint, and, in particular, is concerned with electrical transport properties of atomic scale thin films structures of the TI Bi2Se3 grown by the molecular beam epitaxy technique. We first begin by reviewing the nascent field of TIs, which will act to motivate the work. This will be followed by a thorough introduction to the many aspects concerning the synthesis of thin film TIs by the atomically precise technique of molecular beam epitaxy. This is then followed by a brief introduction to, and the details of electrical transport, which is the main experimental technique used in this work. In the remaining chapters we apply these techniques to understand the fundamental properties of this new class of materials.   As a point of necessity, we first discuss the effects that exposure to atmospheric gases have on the transport properties of Bi2Se3. Following this, we examine the properties of (Bi1-xInx)2Se3, which transitions from a topological insulator (x = 0) into a topologically trivial band insulator (x = 1) through three quantum critical points. We then detail two studies that probe the intrinsic properties of the topological surface states. The first study deals with the emergence of decoupled topological surface states when the metallic bulk state is suppressed. The second study presents a new phase called an inverse TI, whose electronic properties can be engineered chemically, which is found to allow control over the coupling between the topological surface states. This will lead into the final work, which is concerned with understanding the global properties of transport measurements on TIs.
“Puis que ainsi est.” the material and rhetorical effects of book production on French renaissance tales
Creators: name: Branton-Desris, Jenifer
Publisher: name: No Publisher Supplied
Year: 2014

description: Collections of nouvelles were very popular in the sixteenth century, despite their status as an “unworthy” genre. Numerous editions of some of the most popular collections were printed quickly. This study aims to determine the extent to which practices in the French book industry affected the rhetorical status and value of texts printed then; it focuses on Bonaventure Des Périers’ Nouvelles Récréations et Joyeux Devis (1558), Noël Du Fail’s Propos rustiques (1548) and Baliverneries d’Eutrapel (1549), and Marguerite de Navarre’s Heptaméron (1558). Two of the works were published posthumously, but the public response to different editions of each author’s collection ranged from acceptance to disdain. Noël Du Fail was alive when his two collections were initially printed, and was involved in a second edition of each, but counterfeit, interpolated editions actually became dominant. The first Part of this study is an examination of practices in the book industry, and the involvement of several of the booksellers, to determine the material nature and the most likely reasons for the presence of variant editions. Questions of authenticity play an important role in the justification for printing new editions and their reception. In Part II, the focus shifts on differences between the editions themselves. We see how variants and interpolations change the rhetorical substance of a work with respect to both inventio and dispositio. The proposed “contracts” with the reader found in the beginning of the Nouvelles Récréations and the Propos rustiques and the Baliverneries d’Eutrapel are fulfilled in different ways in the alternate editions, whereas the extraordinary differences between the first two printed editions of the Heptaméron allow for a different form of comparison. Ultimately, the industry possesses the power and the incentive to alter the structure and meaning of collections of tales; while the product that contemporary readers might have known and liked best may not have been the text intended by the author, it is important to recognize that these “faulty” versions have a logic of their own and, as such, have a lot to tell us about the history and poetics of the genre.
Comparative genomics of the stem transcriptome from grain and sweet sorghum
Creators: name: Calviño Torterolo, Martĺn
Publisher: name: No Publisher Supplied
Year: 2014

description: The current dissertation relates to comparative genomics of grain and sweet sorghum, in particular, to their stem’s transcriptome at the time of flowering, when soluble sugars accumulate more abundantly in the sweet sorghum cultivar Rio than in the grain sorghum cultivar BTx623. The accumulation of soluble sugars in the stem of sorghum is a valuable agronomic trait because their fermentation into ethanol is currently being used as source of biofuel.  High soluble sugar content in stems is a trait also present in the closely related grass sugarcane. Thus, it is reasonable to assume that sweet sorghum and sugarcane may use the same gene products that leads to high soluble sugar content is stems.   My dissertation consists of five chapters, the results of which are five publications as first author. In Chapter 1 I summarized the current status of sweet sorghum genomics and highlighted future research directions. My scientific contribution to the field was also mentioned. In Chapters 2 and 3 I described the first characterization of the stem’s transcriptome from grain and sweet sorghum cultivars using sugarcane Affymetrix arrays, and the use of this transcriptome data to develop molecular markers based on the differences in hybridization intensity from grain and sweet sorghum RNAs to the arrays.  In Chapter 4, I described the first characterization of the small RNA component of the stem from grain sorghum BTx623 and sweet sorghum Rio cultivars, and from F2 plants derived from their cross that segregated for sugar content and flowering time. I was able to identify the microRNA family miR169, whose expression co-segregated with sugar content in stems. I also discovered nine new microRNAs in the sorghum genome. In Chapter 5 I described the genomic comparison of MIR169 gene clusters among five different grasses and identified five new MIR169 gene copies in the sorghum genome.
Mathematization in introductory physics
Creators: name: Brahmia, Suzanne M.
Publisher: name: No Publisher Supplied
Year: 2014

description: Mathematization is central to STEM disciplines as a cornerstone of the quantitative reasoning that characterizes these fields.  Introductory physics is required for most STEM majors in part so that students develop expert-like mathematization. This dissertation describes coordinated research and curriculum development for strengthening mathematization in introductory physics; it blends scholarship in physics and mathematics education in the form of three papers.    The first paper explores mathematization in the context of physics, and makes an original contribution to the measurement of physics students’ struggle to mathematize. Instructors naturally assume students have a conceptual mastery of algebra before embarking on a college physics course because these students are enrolled in math courses beyond algebra. This paper provides evidence that refutes the validity of this assumption and categorizes some of the barriers students commonly encounter with quantification and representing ideas symbolically.    The second paper develops a model of instruction that can help students progress from their starting points to their instructor’s desired endpoints.   Instructors recognize that the introductory physics course introduces new ideas at an astonishing rate. More than most physicists realize, however, the way that mathematics is used in the course is foreign to a large portion of class. This paper puts forth an instructional model that can move all students toward better quantitative and physical reasoning, despite the substantial variability of those students’ initial states.    The third paper describes the design and testing of curricular materials that foster mathematical creativity to prepare students to better understand physics reasoning.  Few students enter introductory physics with experience generating equations in response to specific challenges involving unfamiliar quantities and units, yet this generative use of mathematics is typical of the thinking involved in doing physics.  It contrasts with their more common experience with mathematics as the practice of specified procedures to improve efficiency. This paper describes new curricular materials based on invention instruction provide students with opportunities to generate mathematical relationships in physics, and the paper presents preliminary evidence of the effectiveness of this method with mathematically underprepared engineering students.
Merocoremia monnei Marques 1994
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Merocoremia
Merocoremia monnei

description: 24. Merocoremia monnei Marques, 1994b: 350, figs. 1 – 36 Holotype, male
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 344, DOI: 10.5281/zenodo.250291
Homologous recombination sites during drosophila female meiosis and the role of the drosophila ino80 complex in meiotic recombination
Creators: name: Cardona, Cristina Ochoa
Publisher: name: No Publisher Supplied
Year: 2014

description: DNA Double Strand breaks (DSBs) are one of the most lethal types of genomic damage.  Irregularities in the repairs of DSBs can lead to chromosomal aberrations, such as deletions, translocations, and inversions that ultimately are responsible for cancer, infertility, and birth defects.  Cells have several conserved and controlled DNA repair pathways, in which a plethora of factors must be activated and recruited to the break.  Moreover, eukaryotes must also locally and transiently modify chromatin to allow access of repair factors.  Very little is known about chromatin remodeling during DSB processing in higher eukaryotes, partially due to the lack of suitable study models.    Here I used Drosophila female meiosis as the model and show the development of a marker and fixation protocol that enables the labeling and following of DSB sites during recombinational repair.  Moreover, I provide evidence that early and late repair sites correspond to non-crossovers (NCO) and crossovers (CO), respectively.  In the next part of this study, I provide novel evidence that: 1) COs persist longer than NCOs and are mobilized to the nuclear periphery, 2) movement of COs to the periphery is developmentally controlled, depends on ATR, and occurs during mid-pachytene when NCOs are repaired, 3) any persisting DSB can form MRN foci that are mobilized to the periphery from mid-pachytene on.    Furthermore, I focus on the role of dINO80, an ATP-dependent chromatin remodeler, during meiotic recombination.  To date it has never been shown that INO80 has a role in meiosis or whether it functions in early recognition steps.  Here I show that Ino80, the catalytic subunit of the INO80 complex, interacts in a damage dependent fashion with components of the MRN complex, and that Ino80 is required for the recognition of the majority of meiotic DSBs.  Furthermore this study suggests that the ATP-dependent remodeling function of dIno80 is crucial for its role in recognition of meiotic DSBs.  Drosophila female meiosis in conjunction with the developed techniques in this study provide a powerful system to study the dynamics of meiotic DSB sites and to spatially and temporally dissect the role of chromatin modifying complexes in DSB repair.
Targeting Histone Acetyltransferase in Triple Negative Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Triple negative breast cancer (TNBC) is very aggressive and poses a challenge for treatment. Because it lacks expression of the estrogen, progesterone, and Her-2 receptors, TNBC is not a candidate for targeted anti-estrogen, aromatase inhibitor, or anti-HER-2 therapy. An important unmet challenge in breast cancer research is to identify a therapeutic target for TNBC. We believe histone acetyltransferase (HAT) would represent such a therapeutic target for TNBC, because it plays a central role in DNA metabolism and DNA repair functions that are critical for TNBC cell survival. Histone acetyltransferases (HAT) are enzymes that acetylate conserved lysine amino acids on histone (chromosomal DNA-associated) proteins to regulate DNA activity. Our specific approach will employ a class of cancer-specific polyamine-CoA-based inhibitors of HAT that suppress multiple mechanisms of DNA repair, thereby exploiting the unique susceptibility of TNBC.

 For our studies, we will use cultured breast cancer cells derived from TNBC and other types of breast cancer as well as mouse models for human breast cancer to evaluate the mechanism by which our polyamine-CoA-based inhibitors suppress TBNC cell growth and to evaluate their anti-tumor efficacy. We will use cell-based methodologies to determine the effects of our inhibitors on the growth and viability of TNBC and other breast cancer cell types in cell culture. We will use biochemical methodologies to evaluate the uptake and stability of our inhibitors in breast cancer cells, and to measure their effects on HAT, DNA synthesis and DNA repair. We will use mouse models for localized and metastatic human breast cancer to determine the anti-tumor effects of our

 inhibitors, and to evaluate any potential toxicity.

 TNBC affects some 170,000 women worldwide each year, and constitutes a disproportionate percentage of breast cancer deaths. There is a critical need to identify new therapeutic targets for TNBC and to use them to develop targeted, more effective and less toxic therapies as alternatives when conventional chemotherapy fails. The histone acetyltransferase-targeted compounds investigated here could offer a targeted, non-toxic alternative to chemotherapy, and provide long term control or cures for TNBC while preserving quality of life.
The bacteriocin subtilosin A and synergistically acting conventional antimicrobials for control of bacterial vaginosis-associated pathogens
Creators: name: Cavera, Veronica L.
Publisher: name: No Publisher Supplied
Year: 2014

description: Bacterial vaginosis is one of the most prevalent vaginal infections in women of child-bearing age and is caused by the shift of healthy lactobacilli to anaerobic pathogenic bacteria including Gardnerella vaginalis. While current antibiotic treatments were initially effective there is increasing evidence of resistance as well as damage to normal flora. The papers herein address the usage of bacteriocins for the purpose of indicating methods of more efficiently inhibiting G. vaginalis while having little effect on normal flora. (i) is a review on the current landscape of antibiotics and posits that bacteriocins present a viable option as either synergists to current antibiotics or as potential next generation option. (ii) is a research paper on the interaction of four antimicrobials (lauramide arginine, ε-poly-L-lysine, clindamycin phosphate and metronidazole) and subtilosin against G. vaginalis and four clinical isolates of lactobacilli. The combinations of CS and MS were synergistic in terms of FICI while all tested combinations displayed Bliss synergy against G. vaginalis. (iii) is a research paper in which a polyethylene glycol (PEG) gel with passively entrapped subtilosin was shown to cause a 8 log10 CFU/ml reduction of G. vaginalis with quantities < 15 μg/mL of subtilosin in a bimodal release kinetic in OD595 endpoint experiments. No inhibition of lactobacilli spp. was observed. Rheological properties were also recorded, indicating the gel is appropriate for vaginal application. (iv) is a polycarbophil Carbopol® 934P hydrogel which encapsulates benzoyl peroxide capable of inhibiting G. vaginalis but not normal vaginal lactobacilli. Gels with 0.01% v/v of BPO inhibited G. vaginalis while gels with 2.5% v/v of BPO inhibited tested lactobacilli in direct contact time kill assays and well diffusion assays. Rheological tests indicated that the gel was ideal for human usage and that the addition of BPO did not alter its physiochemical properties. (v) is a review that discusses bacteriocins and their usage in delivery systems. Each paper is linked through the ideas that of bacteriocins (i, ii, iii, v), bacteriocins and BV (ii, iii), BV (ii, iii, iv) or drug delivery systems (ii, iii, iv, v).
Additional file 3: Figure S1. of Reduced suppressive effect of β2-adrenoceptor agonist on fibrocyte function in severe asthma
Creators: name: Lo, Chun-Yu
name: Michaeloudes, Charalambos
name: Bhavsar, Pankaj
name: Chien-Da Huang
name: Po-Jui Chang
name: Wang, Chun-Hua
name: Han-Pin Kuo
name: Chung, Kian
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 60506 Virology

description: α–smooth muscle actin-positive cells also express both collagen I and CD45. NANT cells from one healthy subject were harvested after 3 days in culture and stained with antibodies for collagen I (Col I), α- smooth muscle actin (SMA) and CD45 or their respective IgG isotype controls. (A and C). The percentage of Col I+/α-SMA+ (B) and CD45+/ α-SMA+ cells (D) was determined by flow cytometry. (PDF 112 kb)
Ardeadoris symmetrica
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Ardeadoris
Ardeadoris symmetrica

description: Ardeadoris symmetrica (Rudman, 1990)
(Figure 3 F)
Material examined. One specimen. MB28-004611, ZAR, 22 Aug. 2012, 31m, 38mm, collected by A. Pouris.
Habitats. Subtropical rocky reef.
Occurrences. Zavora.
Geographic distribution. Indo-west Pacific. Marshall Islands, Papua New Guinea (Rudman 1990), Japan, (Gosliner et al. 2008), British Indian Ocean Territory (Yonow et al. 2002), Réunion Island (Rudman 1990), South Africa (Gosliner et al. 2008) and Mozambique (King & Fraser 2014).
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on page 15, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Potiapua antonia Napp & Monne 2009
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy

description: Type locality. Brazil, Espírito Santo: Baixo Guandú, 26-30.XI.1971, C. Elias 25. Potiapua antonia Napp & Monné, 2009: 33, figs. 2 – 4 Holotype, male
Type locality. Brazil, Espírito Santo: Santa Teresa, 06.XI.1976, C.T. & C. Elias
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on pages 344-345, DOI: 10.5281/zenodo.250291
MOESM2 of High-throughput SuperSAGE for gene expression analysis of Nicotiana tabacum–Rhizoctonia solani interaction
Creators: name: Portieles, Roxana
name: Ochagavia, María
name: Canales, Eduardo
name: Yussuan Silva
name: Osmani Chacón
name: Hernández, Ingrid
name: Yunior López
name: Rodríguez, Mayra
name: Terauchi, Ryohei
name: Borroto, Carlos
name: Santos, Ramón
name: Bolton, Melvin
name: Ayra-Pardo, Camilo
name: Borrás-Hidalgo, Orlando
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 60506 Virology

description: Additional file 2: Table S1. Summary of all the analyzed SuperSAGE libraries.
Morphological transformations in polymer brushes in binary mixtures
Creators: name: Cheng, Jianli
Publisher: name: No Publisher Supplied
Year: 2014

description: Morphological transformations in polymer brushes in a binary mixture of good and bad solvents are studied using dissipative particle dynamics (DPD) simulations drawing on a characteristic example of polyisoprene natural rubber (PINR) in acetone – benzene mixture. A coarse-grained DPD model of this system is built based on the literature experimental data available. We focus on the transformation of dense collapsed brush in bad solvent (acetone) to expanded brush solvated in good solvent (benzene) as the concentration of benzene increases. A coarse-grained DPD model of this system is built based on the literature experimental data available. Compared to a sharp globule-to-coil transition observed in individual tethered chains, collapsed-to-expanded transformation in brushes is found to be gradual without a prominent transition point. The transformation becomes more leveled as the brush density increases. At low densities, the collapsed brush is highly inhomogeneous and patterned forming bunches composed of neighboring chains due to favorable polymer-polymer interaction. At high densities, the brush is expanded even in the bad solvent due to steric restrictions. In addition, we considered a model system similar to the PINR-acetone-benzene system, but with the interactions between the solvent components worsened to the limit of miscibility. Enhanced contrast between good and bad solvents facilitates absorption of the good solvent by the brush, shifting the collapsed-expanded brush transformation to lower concentrations of the good solvent. This effect is especially pronounced for higher brush densities.
A numerical study of heat removal from data center
Creators: name: Chen, Zhong
Publisher: name: No Publisher Supplied
Year: 2014

description: In this work, the physical problem associated with heat removal from data centers is studied. The governing equations and boundary conditions are written and solved numerically using the commercial code Fluent. The model is validated via a classic benchmark problem: natural convection in a square cavity. The problem of cooling the different servers in a data center is discussed in detail. Three configurations of a typical data center are considered. In these configurations, the data center has different locations of the outlet, and all other dimensions are kept the same. Two conditions of constant temperature and constant heat input are considered. The inlet flow velocity, the strength of server volume heat source and the temperature of server are chosen as the main variables during the simulations. By comparing the Nusselt Numbers and the dimensionless temperatures at the surfaces of the servers, the configuration with the best cooling characteristics is determined. The temperature and velocity fields in the data center are given to explain the native of the basic principle and the theory behind the differences among the three configurations.
Epropetes hirsuta Martins & Napp 1984
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Epropetes
Epropetes hirsuta

description: 26. Epropetes hirsuta Martins & Napp, 1984: 437, fig. 5 Holotype, male
Type locality. Brazil, Rio de Janeiro: Rio de Janeiro (Floresta da Tijuca, Represa Rio Grande), II.1961, F.M. Oliveira
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 345, DOI: 10.5281/zenodo.250291
L’intelligenza performativa della meta-arte
Creators: name: Chillemi, Francesco
Publisher: name: No Publisher Supplied
Year: 2014

description: Are the arts an original source of knowledge? Apart from merely providing an aesthetic representation of sensory and reasoned knowledge, to what extent do the arts actively contribute to a deeper understanding of reality?  To what extent can artistic creations – whose intrinsic incompleteness involves both the artist and the audience in the production of meaning – help us grasp the structures of knowledge and the essence of linguistic codes?    The crisis of positivism, the influence of psychoanalytic theories, and the revolutionary discoveries in Physics and Mathematics shaped twentieth-century Western thought, undermining the principles of objectivity and testability of scientific knowledge, and blurring the subjective-objective distinction. Consequently, the quest for a re-foundation of epistemology arose in many fields, bringing into the limelight a strong interest in self-reflexivity in both the sciences and the arts. While formal and scientific disciplines began to investigate their foundations, the advent of modernism and then the influence of the postmodern turn made self-reference (and its subcategory, metareference) an increasingly prominent trait of twentieth-century arts.    To explore the trans-medial and trans-disciplinary phenomenon of self-reference, my dissertation focuses on pertinent twentieth-century Italian works of theatre (Luigi Pirandello’s Six Characters in Search of an Author, 1921-25), literature (Elsa Morante’s novel Menzogna e sortilegio, 1948), and cinema (Carmelo Bene’s film Amleto da Shakespeare a Laforgue, 19&4). Although these works differ in terms of historical time, they share the same goal: a critical inquiry into their respective media. As a result, they tackle the epistemological crux of self-reflection, whose problematic and paradoxical aspects have been, and still are, matter of debate in fields of study such as continental philosophy, (post)analytic philosophy, and mathematical logic, to name a few. In this regard, I argue that, while formal and scientific disciplines are entangled in the logical impasse that self-referential investigations often cause, the arts can expose the structure of a code in a metalinguistic mode. Indeed, the artistic device of performativity provides a meta-dimension by which we can gaze into the represented object from an external perspective.
Additional file 2: of Continuity of care as experienced by mental health service users - a qualitative study
Creators: name: Biringer, Eva
name: Hartveit, Miriam
name: SundfĂ¸R, Bengt
name: Ruud, Torleif
name: Borg, Marit
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: 32-item COnsolidated criteria for Reporting Qualitative research (COREQ) checklist completed for the study. (PDF 509Â kb)
Ardeadoris undaurum
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Ardeadoris
Ardeadoris undaurum

description: Ardeadoris undaurum (Rudman, 1985)
(Figure 3 G)
Material examined. Seven specimens. MB28-004526, ZAR, 14 Mar. 2012, 32m, 11mm; MB28-004641, ZD, 0 4 Dec. 2012, 30m, 55mm; MB28-004 703, ZGWS, 0 3 Aug. 2013, 16m, 42mm; MB28-004713, ZWH, 12 Aug. 2013, 16m, 38mm; MHN-YT872, ZDRS, 12 Aug. 2013, 31m, 46mm; MB28-004937, ZGWS, 11 Oct. 2014, 19m, 28mm; MB28-004985, ZA51, 25 Apr. 2015, 15m, 14mm.
Habitats. Subtropical rocky reefs.
Occurrences. Ponta do Ouro and Zavora.
Geographic distribution. Indo-west Pacific. Indonesia (Katiandago 2017), Gulf of Oman (Debelius 1996; Fatemi & Attaran-Fariman 2015), Australia (Rudman 1985), South Africa (Gosliner 1987) and Mozambique.
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on page 15, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Role of exosomes in rescuing Xerostomia in head and neck cancer patients
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Many head and neck cancer (HNC) patients undergo radiation therapy as part of the treatment for their cancer. The most common long-term side effect of radiation is dry mouth, which is also known as xerostomia. This happens because radiation can damage the salivary glands, leading to a substantial reduction in saliva production. Xerostomia results in difficulty in chewing, swallowing food, dental decay and gum recession, culminating in deterioration of quality of life. Current available treatment options for this condition are not very effective, are costly and provide only temporary symptom relief. Our project focuses on developing a potentially new therapy to permanently prevent and treat xerostomia in HNC patients. In collaboration with Capricor Therapeutics, we will study the effect of exosomes that are produced by a type of stem cells (cardiac) in preventing radiation damage to the salivary glands through protection of salivary stem cells and mitigation of acute inflammation. Exosomes are well characterized small lipid-based molecules carrying specific cargo known to influence tissue function and biology. Work at Capricor has demonstrated that exosomes from cardiac stem cells are effective in improving tissue regeneration after injury in animal models. We have generated preliminary data to show that exosomes treatment improved the capacity of the salivary gland stem cells to multiply. We are excited to extend this work to small animal model where we will study the effect of exosome treatment in the regeneration process of salivary glands after radiation. The results of this study can lead to a novel therapy that can either prevent or reverse xerostomia permanently in HNC patients.
Why are anxiety and depressive symptoms comorbid in youth?
Creators: name: Cohen, Joseph R.
Publisher: name: No Publisher Supplied
Year: 2014

description: Comorbidity, defined as the manifestation of multiple disorders within an individual, has become the rule, rather than the exception. In youth, the co-occurrence of depression and anxiety is not only common, but leads to a more severe course of mental illness and poorer treatment response. Thus, researchers have aimed to understand the development of this frequent, and deleterious, relation. A collection of research points to two developmental explanations for why depression and anxiety may relate: A causal model, in which anxiety predicts depression, and a correlated liabilities model, where shared vulnerability factors predict both anxiety and depression. While promising trends have been identified for both models, a consistent pattern for the development of comorbid symptoms has yet to emerge. The present study sought to clarify past research by introducing a diathesis-anxiety approach to understanding comorbidity in youth. Specifically, we predicted that specific cognitive vulnerabilities would interact with anxiety symptoms to predict prospective depressive symptoms. For this study, 6&8 3rd (n=208), 6th (n=245), and 9th (n=225) grade girls (n=380) and boys (n=298) completed self-report measures at baseline assessing cognitive vulnerabilities (rumination, negative inferential styles, and self-criticism), stressors, depression, and anxiety. Every 3 months over the next 18 months, youth completed follow-up measures of depression, anxiety, and stressors. Findings supported a diathesis-anxiety approach for self-criticism (t(2494) = 3.36, p < .001) and rumination (t(2505) = 2.40, p = .05). On the other hand, partial support was found for a correlated liabilities model, as girls with a negative inferential style were more likely to experience both depressive (t(2518) = 2.66, p = 0.008) and anxiety (t(1436) = 2.08, p = 0.03) symptoms following a negative event. Finally, no support was found for a causal model, as anxiety symptoms did not uniquely predict depressive symptoms (p > .05). These results clarify past results concerning comorbidity by suggesting that multiple pathways exist for comorbid depressive and anxiety states, and by introducing diathesis-anxiety models as an important and novel explanation for comorbid emotional distress in youth. Clinical implications and future developmental psychopathology research on this important topic are discussed.
Extracellular polysaccharides production by bacteria as a mechanism of mercury tolerance
Creators: name: Cruz, Kimberly Anne
Publisher: name: No Publisher Supplied
Year: 2014

description: Bacteria have adapted mechanisms of mercury (Hg) tolerance to survive in environments containing elevated Hg concentrations. The potential of extracellular polysaccharides (EPS) production by bacteria as a mechanism of Hg tolerance has not been previously investigated. The objective of my dissertation was to determine if EPS produced by bacteria sorb Hg as a tolerance mechanism. Purified EPS with different chemical compositions isolated from bacterial pure cultures from microbial mats in French Polynesian atolls were assessed for Hg sorption by filtering Hg and EPS solutions after equilibration via shaking and measuring free vs. bound Hg. The data showed that EPS sorbed up to 82% of Hg from solution, that this sorption was dependent on EPS composition, and the sorption was a saturable mechanism. Hg uptake capacities ranged from 1.0 to 91.2 mg Hg/g for the different EPS. To determine if EPS production could alter Hg tolerance in bacteria during growth, an E. coli K-12 strain and its EPS defective mutant were obtained. A disc inhibition assay was performed demonstrating Hg inhibited growth in a dose-dependent manner. The wild-type was more tolerant to Hg with zones of inhibition ranging from 1.4 to 6.1 mm compared to 2.5 to &.15 mm for the mutant.  Assessment of EPS production between the 2 strains by the phenol- sulfuric acid assay for sugar determination normalized to protein content of bacterial pellet showed the wild-type produced 2 times more EPS than the mutant. Finally, EPS production and Hg tolerance were examined in bacteria isolated from an environment with naturally elevated Hg concentrations. Eight obligate and facultative chemolithoautrophic bacteria tolerant to 10 µM HgCl2 were isolated from the East Pacific Rise at 9ºN. Two of the isolates were selected for further characterization. Purge and trap experiments revealed that neither isolate reduced Hg2+ to Hg0 suggesting that the mer operon is not used for mercury tolerance. The phenol-sulfuric acid assay for sugar determination normalized to protein content of bacterial pellets of 3 facultative chemolithoautotrophs revealed that all 3 isolates produced EPS ranging from 0.5 to 38 µg EPS/mg protein. For 2 of strains, there was 8% and 32% increase in EPS production during growth in the presence of Hg, suggesting that EPS may be involved in tolerance. Together these data suggest EPS production is a potential mechanism of mercury tolerance in bacteria.
Cadlinella ornatissima
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Cadlinella
Cadlinella ornatissima

description: Cadlinella ornatissima (Risbec, 1928)
(Figure 3 H)
Material examined. Four specimens. MB28-004754, PPI, 0 1 Dec. 2013, 1m, 12mm; MB28-004900, NKA, 10 Jun. 2014, 30m, 14mm; MHN-YT1339, NKA, 10 Jun. 2014, 30m, 17mm; ZMBN10 5566, VIPP, 23 May 2015, 10m, 13mm.
Habitats. Tropical coral reefs, sometimes under rocks.
Occurrences. Nacala, Nuarro, Pemba.
Geographic distribution. Indo-west Pacific. New Zealand (Gosliner et al. 2008), Guam (Carlson & Hoff 2003), Japan (Baba 1949), Taiwan, Hong Kong, Fiji (Gosliner et al. 2008), New Caledonia (Risbec 1928), Australia (Nimbs & Smith 2017), Thailand (Mehrota & Scott 2015), India (Remakrishna et al. 2010), British Indian Ocean Territory (Yonow et al. 2002), Sri Lanka, Gulf of Oman, Réunion Island and Mayotte (Yonow 2012), Tanzania (Rudman 1984) and Mozambique.
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on page 16, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Exposure to Marijuana Smoking: the Effect of Proximity
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: With the recent legalization of marijuana in California, marijuana smoke is now an emerging air pollution source of concern, both indoors and outdoors. Previous studies have shown that in close proximity to a cigarette smoker, exposure to secondhand smoke can be five to ten times as high as farther away – this “proximity effect” will also be an issue for individuals who are in proximity to marijuana smoke. If smoking takes place outdoors, or in indoor locations with open windows, others nearby could be inadvertently exposed. If exposure is significant, then important policy issues will need to be addressed.

 There are different methods of smoking marijuana (joint smoking, bong smoking, and vaping), as well as marijuana/tobacco mixtures. Typical smoking behavior (e.g., the frequency and volume of puffs, the duration of breath holding) varies with both the method of smoking and what is being smoked. These variations will lead to differences in the concentrations and persistence of the individual components present in exhaled marijuana smoke, affecting the levels of secondhand exposure nearby.

 This study aims to characterize the levels of secondhand exposure in close proximity to marijuana smoke, focusing on two emission components with significant health implications: fine airborne particles (PM2.5), which can cause measurable respiratory problems in sensitive individuals, and tetrahydrocannabinol (THC), the main psychoactive component in marijuana. PM2.5 will be measured with a high time resolution monitor (multiple measurements every minute), at different distances from the smoker, for different smoking conditions, smoking materials, and locations. For THC, besides measuring the airborne levels at different proximities, this study will also analyze cheek swabs for THC, both for smokers and for non-smokers located nearby, as an independent measure of cumulative exposure. The proximity effect will be assessed over a range of legally-allowed smoking locations, such as living rooms, garages, backyards, and parked cars.

 The results of this research should provide critically needed exposure data for assessing the health risks of marijuana smoking to non-smoking neighbors and bystanders, in real-world situations.