cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Numerical study on steel Plate slit with opening
Creators: name: Redeat  Ashenafi Kassaye
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2020
Subjects: Steel plate shear wall with slits, Rectangular opening, Hysteretic behavior, Finite element method

description: Steel plate shear wall with slit can be used as lateral load resisting system in new building and
 also for seismic retrofitting of existing structure. It possesses efficient energy dissipation
 capacity and good ductility as a result of the installed slits with in the infill steel plate. However,
 when steel plate shear wall is generally chosen as lateral load resisting mechanism, placement of
 utilities is always an issue. In steel plate shear wall with slit the vertical slits of the system are not
 suitable to let utilities pass through them. Diverting those utilities to pass through region other
 than shear wall will increase cost of the project. Thus, openings need to be introduced in slit wall
 system for services. Moreover, openings might be required for other cases like architectural and
 structural purposes. In this study, the effect of introducing cutout to slit wall system will be
 examined under cyclic loading using finite element method. It considered the buckling load,
 ultimate bearing capacity, energy dissipation capacity, initial stiffness and stiffness degradation,
 ductility, damage and cracking patterns of the slit wall. The parametric study includes: the effect
 of presence of the vertical slits, shape of opening, size of rectangular opening, thickness of steel
 plate and presence of edge stiffeners. The result showed that the presence of the vertical slits has
 highly minimized the negative effect of rectangular cutouts on the desired characteristics of steel
 plate shear wall. The initial stiffness of slit wall decreased by only 16.51% when rectangular
 opening of size 150x300 is installed while solid steel plate shear wall showed a degradation by
 39.39% for the same size rectangular opening. Rectangular opening of 1.35% of the total area of
 the slit wall displayed insignificant effect in the hysteretic behavior of the wall system while
 cutting rectangular opening of 10.8% causes a drastic change in its behavior. It was also found
 out that, the buckling resistance of slit wall with edge stiffeners tends to increases with cutting
 rectangular opening while it declines when rectangular cutout is introduced to unstiffened slit
 wall. Moreover, when cutting rectangular opening in slit wall system, edge stiffener is the most
 influential parameter as its presence greatly lower the reduction in hysteretic behavior of the
 wall. Introducing a rectangular opening of size 150x300 in stiffened slit wall caused 1.82%
 decrement in ultimate bearing capacity while the opening resulted in 7.44% decrement when
 installed in unstiffened slit wall system.
Dietary factors and serum antimüllerian hormone concentrations in late premenopausal women
Creators: name: Anderson, C
name: Park, Y.-M. M.
name: Nichols, H.B
name: Sandler, D.P
name: Stanczyk, F.Z
Publisher: name: Elsevier Inc.
Year: 2018

description: Objective: To study the associations between dietary factors and circulating antimüllerian hormone (AMH) concentrations among late premenopausal women. Design: AMH concentrations were measured in serum samples collected at enrollment from 296 women (aged 35−45 years) in the Sister Study cohort. Usual dietary intakes in the past 12 months were assessed using a validated food frequency questionnaire. Dietary exposures of interest included macronutrients, dietary fat subtypes, fiber, and glycemic index. Multivariable linear regression was used to evaluate associations between dietary variables and serum AMH concentrations. We also used nutrient density models to examine isocaloric replacement of macronutrients. Setting: Not applicable. Patients: Women aged 35−45 years. Interventions: Not applicable. Main outcome measures: Serum AMH concentrations in nanograms per milliliter (ng/mL). Results: AMH concentrations were positively associated with percentage of energy from carbohydrates (β per 5% calories = 0.141 [95% CI 0.023, 0.259]; P trend =.019), and inversely associated with percentage of energy from fat (β per 5% calories = −0.152 [95% CI −0.299, −0.004]; P trend =.044). In analyses of dietary fat subtypes, AMH decreased with increasing monounsaturated fatty acids (P trend =.082) and polyunsaturated fatty acids (P trend =.043), particularly ω-6 fatty acids (P trend =.044), whereas no strong trend was observed for saturated fatty acids. Protein and alcohol intake were not strongly associated with AMH. Conclusions: Our cross-sectional analyses in a sample of late premenopausal women suggest that dietary fat intake may be inversely associated with circulating AMH concentrations. Further research in prospective studies is warranted to evaluate dietary factors as potential modifiers of ovarian reserve.
Conditional relative survival among long-term survivors of adolescent and young adult cancers
Creators: name: Nichols, H.B
name: Anderson, C
name: Smitherman, A.B
Publisher: name: John Wiley and Sons Inc.
Year: 2018

description: BACKGROUND: Many studies have examined long-term outcomes after childhood cancer, but few address outcomes for adolescent and young adult (AYA; those aged 15-39 years) cancer survivors. Conditional survival reflects changing mortality risk with time since cancer diagnosis and is a useful measure for planning long-term follow-up care. METHODS: Using the Surveillance, Epidemiology, and End Results registry 9 database, the authors identified a cohort of AYA patients diagnosed with a first malignant cancer between 1973 and 2009 and followed through 2014. They estimated 5-year relative survival at the time of diagnosis and at each additional year survived up to 25 years after diagnosis, conditional on the individual being alive at the beginning of that year. RESULTS: A total of 205,954 AYA patients with cancer were identified. Thyroid cancer, melanoma, testicular cancer, breast cancer, lymphoma, leukemia, and central nervous system (CNS) tumors comprised 67% of all cancers. For all cancers combined, 5-year relative survival was 84.5% (95% confidence interval, 84.3%-84.7%) at 1 year after diagnosis and 94.0% (95% CI, 93.9%-94.2%) at 5 years. The relative survival first exceeded 95%, reflecting minimal excess mortality compared with the general population, at 7 years. Patients with thyroid cancer, testicular cancer, melanoma, and breast cancer reached a relative survival of >95% at the time of diagnosis and at 1, 3, and 18 years after diagnosis, respectively. Estimates for those with Hodgkin lymphoma and leukemia were >95% at 6 and 13 years, respectively, but declined to <95% at 20 years. AYA individuals with CNS tumors did not reach 95% by 25 years after diagnosis. CONCLUSIONS: For AYA survivors of breast cancer, CNS tumors, and hematologic malignancies, long-term excess mortality should be considered when planning follow-up care. Cancer 2018;124:3037-43
title: sainte Dorothée
Creators: name: Centre De Recherches Historiques / Anthropologie Historique Du Long Moyen Âge
Publisher: name: EHESS (School for Advanced Studies in Social Sciences)
Year: 2019

description: Martyre pendant la persécution de Dioclétien, en 311 ; associée à saint Théophile qu'elle convertit après sa mort ; attributs : une corbeille de roses, une couronne de fleurs sur la tête, une branche de rose à la main.
Changes in cardiovascular disease risk and risk factors among women with and without breast cancer
Creators: name: Sandler, D.P
name: Park, Y.-M.M
name: Anderson, C
name: Deal, A.M
name: Nichols, H.B
Publisher: name: John Wiley and Sons Inc.
Year: 2018

description: Background: Cardiovascular disease (CVD) risk is an important health concern among survivors of breast cancer. However, few studies to date have examined whether trajectories of CVD risk and major risk factors are worse among women with a breast cancer diagnosis compared with those without. Methods: Changes in weight, body mass index, waist circumference, systolic blood pressure, and 10-year CVD risk were compared between women with (813 women) and without (1049 women) an incident breast cancer diagnosis while they were enrolled in the National Institute of Environmental Health Sciences Sister Study cohort. Blood pressure and adiposity measures were collected by trained examiners at an enrollment visit (≥1 year before breast cancer diagnosis) and a second home visit 4 to 11 years later (≥1 year after breast cancer diagnosis). The non–laboratory-based Framingham risk score, a measure of 10-year general CVD risk, was calculated at both the enrollment and second visits. All analyses were stratified by menopausal status at the time of enrollment. Results: Women who were premenopausal at the time of enrollment experienced moderate increases in weight, waist circumference, systolic blood pressure, and CVD risk over the study period. Those who were postmenopausal at the time of enrollment demonstrated little change in weight, but were found to have increases in waist circumference, systolic blood pressure, and CVD risk. In both groups, changes over time did not differ significantly according to breast cancer status. Neither chemotherapy nor endocrine therapy were found to be associated with greater increases in CVD risk or risk factors. Conclusions: In the current study cohort, changes over time in CVD risk, adiposity measures, and blood pressure were similar between women who developed an incident breast cancer and those who did not.
Factors associated with breast MRI use among women with a family history of breast cancer
Creators: name: Sandler, D.P
name: Hodgson, M.E
name: Nichols, H.B
name: Weinberg, C.R
name: DeRoo, L
name: Peipins, L.A
name: Sabatino, S.A
name: White, M.C
name: Rodriguez, J.L
name: Soman, A
Publisher: name: Blackwell Publishing Inc.
Year: 2018

description: Although annual breast magnetic resonance imaging (MRI) is recommended for women at high risk for breast cancer as an adjunct to screening mammography, breast MRI use remains low. We examined factors associated with breast MRI use in a cohort of women with a family history of breast cancer but no personal cancer history. Study participants came from the Sister Study cohort, a nationwide, prospective study of women with at least 1 sister who had been diagnosed with breast cancer but who themselves had not ever had breast cancer (n = 17 894). Participants were surveyed on breast cancer beliefs, cancer worry, breast MRI use, provider communication, and genetic counseling and testing. Logistic regression was used to assess factors associated with having a breast MRI overall and for those at high risk. Breast MRI was reported by 16.1% and was more common among younger women and those with higher incomes. After adjustment for demographics, ever use of breast MRI was associated with actual and perceived risk. Odds ratios (OR) were 12.29 (95% CI, 8.85-17.06), 2.48 (95% CI, 2.27-2.71), and 2.50 (95% CI, 2.09-2.99) for positive BRCA1/2 test, lifetime breast cancer risk ≥ 20%, and being told by a health care provider of higher risk, respectively. Women who believed they had much higher risk than others or had higher level of worry were twice as likely to have had breast MRI; OR = 2.23 (95% CI, 1.82-2.75) and OR = 1.76 (95% CI, 1.52-2.04). Patterns were similar among women at high risk. Breast cancer risk, provider communication, and personal beliefs were determinants of breast MRI use. To support shared decisions about the use of breast MRI, women could benefit from improved understanding of the chances of getting breast cancer and increased quality of provider communications.
title: NMR-crystallographic study of two-dimensionally self-assembled cyclohexane-based low-molecular-mass organic compounds
Creators: name: Schmidt, Marko
name: Zehe, Christoph S.
name: Siegel, Renee
name: Heigl, Johannes U.
name: Steinlein, Christoph
name: Schmidt, Hans-Werner
name: Senker, Jürgen
Publisher: name: University of Bayreuth
Year: 2013
Subjects: subject: 540

description: Using a combined approach based on scanning electron microscopy, powder X-ray diffraction as well as 1D and 2D multinuclear solid-state NMR spectroscopy, we were able to determine the morphology and the crystal structures for a set of three supramolecular compounds with different hydrogen bonding motifs, namely N,N′-(cyclohexane-trans-1,4-diyl)bis(2,2-dimethylpropanamide) 1, 1,1′-(cyclohexane-trans-1,4-diyl)bis(3-tert-butylurea) 2 and N1,N4-bis(tert-butylcarbamoyl)cyclohexane-trans-1,4-dicarboxamide 3. Based on a complete signal assignment of the 1D solid-state MAS NMR spectra (1H, 13C, 15N) employing 2D HETCOR experiments and a quantitative evaluation of the corresponding resonances, the content of the asymmetric unit was determined to one half of a molecule. Probing the molecular configuration with 1H–1H double-quantum experiments revealed an intramolecular hydrogen bond for compound 3 while 1 and 2 form exclusively intermolecular H-bonds. Ab initio structure solutions applying real space methods with an included close-contact penalty were carried out for all compounds. The following Rietveld refinements led to excellent wRp-values between 2.5% and 4.1%. Compounds 1 and 2 crystallise isostructurally in the monoclinic space group P21/c exhibiting a pseudo-biaxial hydrogen bond motif. 3 crystallises in the triclinic space group Pwith intermolecular head-to-tail hydrogen bonds connecting the molecules to one-dimensional ribbons. Nevertheless, all compounds grow in a sheet-like morphology with lateral dimensions of several hundred micrometres indicating a fast growth in two dimensions along two of the crystal axes. Since all three molecules possess inversion symmetry cancelling the molecular dipole moment the growth mechanism itself has to be dominantly driven by the formation of hydrogen bond networks.
Supplementary Materials for Kelsey Cotton Licentiate Thesis, 2024
Creators: name: Cotton, Kelsey
Publisher: name: Zenodo
Year: 2024

description: Complementary media for the licentiate thesis: Musical AI Voices: Facts, Concerns and Experimental Musical Practices with AI Voice Tools, by Kelsey Cotton, 2024

Chalmers University of Technology

This collection contains the following media:

File name: P4-E1.pptxDescription: An collation of SpeechBrain ASR transcriptions into a volume of poetry, which is an artwork produced by Kelsey Cotton

File names: P4-A1.wav; P4-A2.wav; P4-A3.wav; PA-A4.wav; P4-A5.wav; P4-A6.wavDescription: The above files are embedded within the publication "Sounding out extra-normal AI voice: Non-normative musical engagements with normative AI voice and speech technologies", published in the 2024 proceedings of the International Conference on AI and Musical Creativity in Oxford, United Kingdom. These files are excerpts of Kelsey's voice during various extra-normal vocal gestures; and translations of transcribed vocal gestures (from Kelsey) into different languages based on the deployment of an Automatic Speech Recognition model described in the paper. It is suggested to refer to the paper [1] when referring to and listening to these examples.  

File names: P5-A1.wav; P5-A2.wav; P5-A3.wav; P5-A4.wav; P5-A5.wavDescription: The above files are embedded within the publication "glemöhnic", published in the 2024 proceedings of the International Conference on AI and Musical Creativity in Oxford, United Kingdom. These files are excerpts from a performance pipeline described in the paper. The pipeline uses a combination of Automatic Speech Recognition models and Text to Speech synthesis models to produce a sample bank of warped clones of Kelsey's voice, which are then deployed as samples in the live coding platform strudelREPL. It is suggested to refer to the paper [2] when referring to and listening to these examples.  

LICENSE

All media are released under a Creative Commons Attribution Non Commercial 4.0 International license. 

Usage of media for commercial purposes:

If you'd like to use any of the media for commercial purposes, please contact Kelsey Cotton at kelseyicotton@gmail.com

REFERENCES AND LINKS

[1] Cotton, K., & Tatar, K. (2024). Sounding out extra-normal AI voice: Non-normative musical engagements with normative AI voice and speech technologies. AIMC 2024 (09/09 - 11/09 ). Retrieved from https://aimc2024.pubpub.org/pub/extranormal-aivoice

[2] Cotton, K. (2024). glemöhnic. AIMC 2024 (09/09 - 11/09 ). Retrieved from https://aimc2024.pubpub.org/pub/glemonic

ACKNOWLEDGMENTSThis work was funded by the Wallenberg AI, Autonomous Systems and Software Program – Humanities and Society (WASP-HS) funded by the Marianne and Marcus Wallenberg Foundation and the Marcus and Amalia Wallenberg Foundation.
Endocrine therapy initiation and medical oncologist utilization among women diagnosed with ductal carcinoma in situ
Creators: name: Wheeler, S.B
name: Nichols, H.B
name: Anderson, C
name: Meyer, A.M
name: Reeder-Hayes, K.E
name: Zhou, L
Publisher: name: AlphaMed Press
Year: 2017

description: Background. Though randomized clinical trials have demonstrated a reduction in second breast events with endocrine therapy among women with ductal carcinoma in situ (DCIS), use of these therapies remains highly variable. The purpose of this study was to evaluate patient and treatment-related factors associated with endocrine therapy initiation and medical oncology specialty utilization after DCIS. Materials and Methods. We identified women with a DCIS diagnosis during 2006-2010 in the North Carolina Central Cancer Registry with linked public and private insurance claims in the University of North Carolina Integrated Cancer Information Surveillance System data resource. Multivariable generalized linear regression models were used to estimate risk ratios (RR) and 95% confidence intervals (CI) for endocrine therapy initiation in the year following DCIS diagnosis. Results. Among 2,090 women with a DCIS diagnosis, 37% initiated endocrine therapy. Initiation was less common among women aged 75+ at diagnosis (RR=0.79; 95% CI: 0.64-0.97 vs. age 45-54) and women treated with breast-conserving surgery (BCS) who did not receive radiation (RR=0.63; 95% CI: 0.50-0.78 vs. BCS plus radiation). Consultation with a medical oncologist was strongly associated with endocrine therapy initiation (RR=1.40; 95% CI: 1.23-1.61). Women who saw a medical oncologist more often had private insurance, higher census tract-level income, hormone receptor positive disease, and treatment with BCS and radiation. Conclusion. Treatment strategies for DCIS remain controversial. Our data suggest that endocrine therapy is more often used in addition to standard therapies such as BCS plus radiation, rather than as an alternative to radiation.
Endocrine Therapy Initiation among Older Women with Ductal Carcinoma In Situ
Creators: name: Dusetzina, S.B
name: Winn, A.N
name: Nichols, H.B
name: Anderson, C
Publisher: name: Hindawi Limited
Year: 2017

description: Background. Although treatment of ductal carcinoma in situ (DCIS) is controversial, national guidelines recommend considering endocrine therapy for women with estrogen receptor- (ER-) positive DCIS or those undergoing breast conserving surgery (BCS) without radiation. We evaluated uptake and predictors of endocrine therapy use among older women with DCIS. Methods. In the SEER-Medicare database, we identified women aged 65+ years diagnosed with DCIS during 2007-2011. We evaluated demographic, tumor, and treatment characteristics associated with endocrine therapy initiation. Results. Among 2,945 women with DCIS, 41% initiated endocrine therapy (66% tamoxifen, 34% aromatase inhibitors). Initiation was more common among women with ER-positive than ER-negative DCIS (48% versus 16%; HR = 3.75, 95% CI: 2.91-4.83); 28% of women with unknown ER status initiated endocrine therapy. Initiation was less common after BCS alone compared to BCS with radiation (32% versus 50%; HR = 0.69, 95% CI: 0.59-0.80). Conclusions. Less than half of older women with DCIS initiate endocrine therapy to prevent second breast cancers. Our findings suggest use was more common, but not exclusive, among women with ER-positive DCIS, but not among women who underwent BCS alone. Endocrine therapy should be targeted toward patients most likely to benefit from its use.
Training in the Conduct of Population-Based Multi-Site and Multi-Disciplinary Studies: the Cancer Research Network’s Scholars Program
Creators: name: Field, T.S
name: Nichols, H.B
name: Clancy, H.A
name: Pawloski, P.A
name: Buist, D.S.M
name: McDonald, S
name: Greenlee, R.T
name: Banegas, M.P
name: Doria-Rose, V.P
name: Kushi, L.H
name: Epstein, M.M
Publisher: name: Springer New York LLC
Year: 2017

description: Expanding research capacity of large research networks within health care delivery systems requires strategically training both embedded and external investigators in necessary skills for this purpose. Researchers new to these settings frequently lack the skills and specialized knowledge conducive to multi-site and multi-disciplinary research set in delivery systems. This report describes the goals and components of the Cancer Research Network (CRN) Scholars Program, a 26-month training program developed to increase the capacity for cancer research conducted within the network’s participating sites, its progression from training embedded investigators to a mix of internal and external investigators, and the content evolution of the training program. The CRN Scholars program was launched in 2007 to assist junior investigators from member sites develop independent and sustainable research programs within the CRN. Resulting from CRN’s increased emphasis on promoting external collaborations, the 2013 Scholars program began recruiting junior investigators from external institutions committed to conducting delivery system science. Based on involvement of this broader population and feedback from prior Scholar cohorts, the program has honed its focus on specific opportunities and issues encountered in conducting cancer research within health care delivery systems. Efficiency and effectiveness of working within networks is accelerated by strategic and mentored navigation of these networks. Investing in training programs specific to these settings provides the opportunity to improve multi-disciplinary and multi-institutional collaboration, particularly for early-stage investigators. Aspects of the CRN Scholars Program may help inform others considering developing similar programs to expand delivery system research or within large, multi-disciplinary research networks.
The SAGEX Review on Scattering Amplitudes, Chapter 4: Multi-loop Feynman Integrals
Creators: name: Blümlein, Johannes
name: Schneider, Carsten
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2022
Subjects: computer, algebra
Feynman graph
scattering amplitude
higher-order
field theory
effective field theory

description: The analytic integration and simplification of multi-loop Feynman integrals to special functions and constants plays an important role to perform higher order perturbative calculations in the Standard Model of elementary particles. In this survey article the most recent and relevant computer algebra and special function algorithms are presented that are currently used or that may play an important role to perform such challenging precision calculations in the future. They are discussed in the context of analytic zero, single and double scale calculations in the Quantum Field Theories of the Standard Model and effective field theories, also with classical applications. These calculations play a central role in the analysis of precision measurements at present and future colliders to obtain ultimate information for fundamental physics.
The hadronic running of the electromagnetic coupling and the electroweak mixing angle from lattice QCD
Creators: name: Cè, Marco
name: Gérardin, Antoine
name: Hippel, Georg von
name: Meyer, Harvey B.
name: Miura, Kohtaroh
name: Ottnad, Konstantin
name: Risch, Andreas
name: José, Teseo San
name: Wilhelm, Jonas
name: Wittig, Hartmut
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2022
Subjects: current, vector
vacuum polarization, hadronic
electroweak interaction, mixing angle
quantum chromodynamics, perturbation theory
coupling, electromagnetic
pi, mass
fermion, Wilson
GeV
tension
lattice field theory
Euclidean
lattice
flavor
weak coupling
gauge field theory
pole

description: We compute the hadronic running of the electromagnetic and weak couplings in lattice QCD with $N_\mathrm{f}=2+1$ flavors of $\mathcal{O}(a)$ improved Wilson fermions. Using two different discretizations of the vector current, we compute the quark-connected and -disconnected contributions to the hadronic vacuum polarization (HVP) functions $\bar{\Pi}^{\gamma\gamma}$ and $\bar{\Pi}^{\gamma Z}$ for Euclidean squared momenta $Q^2\leq7\,\mathrm{GeV}^{2}$. Gauge field ensembles at four values of the lattice spacing and several values of the pion mass, including its physical value, are used to extrapolate the results to the continuum limit. The ability to perform an exact flavor decomposition allows us to present the most precise determination to date of the isoscalar ($I=0$) mixing HVP function $\bar{\Pi}^{08}$ that enters the running of $\sin^2\theta_{\mathrm{W}}$. Our results for $\bar{\Pi}^{\gamma\gamma}$, $\bar{\Pi}^{\gamma Z}$ and $\bar{\Pi}^{08}$ are presented in terms of rational functions for continuous values of $Q^2$ below $7\,\mathrm{GeV}^{2}$. By combining our lattice result with dispersion theory and perturbative QCD, we obtain $\Delta\alpha^{(5)}_{\mathrm{had}}(M_Z^2)=0.02773(15)$ at the $Z$ boson mass, which agrees with corresponding results based on the $R$-ratio within the quoted uncertainties.
title: saint Irénée
Creators: name: Centre De Recherches Historiques / Anthropologie Historique Du Long Moyen Âge
Publisher: name: EHESS (School for Advanced Studies in Social Sciences)
Year: 2019

description: Disciple de saint Polycarpe, prêtre, puis évêque de Lyon ; il lutta contre l'hérésie gnostique, auteur d'un traité contre les hérésies ; martyr vers 200.
Additional file 2 of Novel compound heterozygous variants in the PCCB gene causing adult-onset propionic acidemia presenting with neuropsychiatric symptoms: a case report and literature review
Creators: name: Li, Yingxuan
name: Wang, Miaomiao
name: Huang, Zhaoyang
name: Ye, Jing
name: Wang, Yuping
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 2. The process of assessing the pathogenicity of the novel mutation for the patient.
Additional file 7: of Genome-wide association study reveals new loci for yield-related traits in Sichuan wheat germplasm under stripe rust stress
Creators: name: Ye, Xueling
name: Li, Jian
name: Cheng, Yukun
name: Yao, Fangjie
name: Long, Li
name: Wang, Yuqi
name: Wu, Yu
name: Li, Jing
name: Wang, Jirui
name: Jiang, Qiantao
name: Kang, Houyang
name: Li, Wei
name: Qi, Pengfei
name: Lan, Xiujin
name: Ma, Jian
name: Liu, Yaxi
name: Jiang, Yunfeng
name: Wei, Yuming
name: Chen, Xianming
name: Liu, Chunji
name: Zheng, Youliang
name: Chen, Guoyue
Publisher: name: figshare
Year: 2019
Subjects: subject: Cell Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology
subject: Virology
subject: Computational Biology

description: Temperatures during the wheat growth seasons in three environments. The plant growth season was from October to the following May. The lowest temperature in CZ18 was lowest among all three environments and lower than 0 °C from December to following February. CZ17 = Chongzhou 2017; MY17 = Mianyang 2017; CZ18 = Chongzhou 2018 (PDF 74 kb)
Wild bootstrap seasonal unit root tests for time series with periodic nonstationary volatility
Creators: name: Cavaliere, Giuseppe
name: Skrobotov, Anton
name: A. M. Robert Taylor
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified

description: We investigate the behavior of the well-known Hylleberg, Engle, Granger and Yoo (HEGY) regression-based seasonal unit root tests in cases where the driving shocks can display periodic nonstationary volatility and conditional heteroskedasticity. Our set up allows for periodic heteroskedasticity, nonstationary volatility and (seasonal) generalized autoregressive-conditional heteroskedasticity as special cases. We show that the limiting null distributions of the HEGY tests depend, in general, on nuisance parameters which derive from the underlying volatility process. Monte Carlo simulations show that the standard HEGY tests can be substantially oversized in the presence of such effects. As a consequence, we propose wild bootstrap implementations of the HEGY tests. Two possible wild bootstrap resampling schemes are discussed, both of which are shown to deliver asymptotically pivotal inference under our general conditions on the shocks. Simulation evidence is presented which suggests that our proposed bootstrap tests perform well in practice, largely correcting the size problems seen with the standard HEGY tests even under extreme patterns of heteroskedasticity, yet not losing finite sample relative to the standard HEGY tests.
title: pH-Channeling in Cancer: How pH-Dependence of Cation Channels Shapes Cancer Pathophysiology
Creators: name: Pethő, Zoltán
name: Najder, Karolina
name: Carvalho, Tiago
name: McMorrow, Roisin
name: Todesca, Luca Matteo
name: Rugi, Micol
name: Bulk, Etmar Michael
name: Chan, Alan
name: Löwik, Clemens W. G. M.
name: Reshkin, Stephan J.
name: Schwab, Albrecht
Publisher: name: University of Muenster, Institutional Repository MIAMI
Year: 2022
Subjects: subject: 610 Medicine and health

description: Tissue acidosis plays a pivotal role in tumor progression: in particular, interstitial acidosis promotes tumor cell invasion, and is a major contributor to the dysregulation of tumor immunity and tumor stromal cells. The cell membrane and integral membrane proteins commonly act as important sensors and transducers of altered pH. Cell adhesion molecules and cation channels are prominent membrane proteins, the majority of which is regulated by protons. The pathophysiological consequences of proton-sensitive ion channel function in cancer, however, are scarcely considered in the literature. Thus, the main focus of this review is to highlight possible events in tumor progression and tumor immunity where the pH sensitivity of cation channels could be of great importance.
description: Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Oxidative Stress and Breast Cancer Risk in Premenopausal Women
Creators: name: Nichols, H.B
name: Milne, G.L
name: Sandler, D.P
name: Anderson, C
name: White, A.J
Publisher: name: Lippincott Williams and Wilkins
Year: 2017

description: Detrimental effects of oxidative stress are widely recognized, but induction of apoptosis and senescence may also have benefits for cancer prevention. Recent studies suggest oxidative stress may be associated with lower breast cancer risk before menopause. Methods: We conducted a nested case-control study (N = 457 cases, 910 controls) within the NIEHS Sister Study cohort of 50,884 women. Premenopausal women ages 35-54 were eligible for selection. We matched controls 2:1 to cases on age and enrollment year and were breast cancer-free at the time of the corresponding case's diagnosis. Oxidative stress was measured by urinary F2-isoprostane and metabolite (15-F2t-isoprostane-M) concentrations. Odds ratios (OR) and 95% confidence intervals (CIs) were calculated with multivariable conditional logistic regression. Results: After multivariable adjustment for body mass index (BMI) and other potential confounders, the OR for breast cancer comparing the >90th (≥2.94 ng/mgCr) to <25th percentile (1.01 ng/mgCr) was 1.1 (CI: 0.65, 1.7) for F2-isoprostane and 0.70 (CI: 0.43, 1.1) for the metabolite. Higher metabolite concentrations were associated with lower breast cancer risk among women who were also premenopausal (353 cases, OR: 0.59, CI: 0.34, 1.0) or <46 years (82 cases, OR: 0.15, CI: 0.06, 0.42) at diagnosis. ORs for the metabolite and breast cancer were inverse among women with BMI 18.5-24.9 kg/m2 (OR: 0.47, CI: 0.18, 1.2, 208 cases) and >30 kg/m2 (OR: 0.71, CI: 0.30, 1.7, 107 cases), but not among women with BMI 25-29.9 kg/m2 (OR: 0.98, CI: 0.39, 2.5, 138 cases). Conclusions: Together with other studies, our results support a possible inverse association between oxidative stress and premenopausal breast cancer risk.
LANGUAGE
Creators: name: Morisseau, Tiffany
name: Noveck, Ira Andrew
name: Morin, Olivier
name: Müller, Thomas Franz
name: Winters, James
name: Noveck, Ira
Publisher: name: OSF Registries
Year: 2018

description: A pre-registered study project for the Color Game, to be disclosed on May the 1st, 2019. See LANGUAGE.pdf.
Sleep characteristics, light at night and breast cancer risk in a prospective cohort
Creators: name: Sandler, D.P
name: Vogtmann, E
name: Park, Y.-M
name: Nichols, H.B
name: D'Aloisio, A.A
name: White, A.J
name: Weinberg, C.R
Publisher: name: Wiley-Liss Inc.
Year: 2017

description: Increasing numbers of women in the US are getting too little sleep. Inadequate sleep has been associated with impaired metabolic function and endocrine disruption. Sister Study cohort participants (n = 50,884), completed baseline and follow-up questionnaires on sleep patterns. Incident breast cancers estrogen receptor (ER) status of the tumor were ascertained from questionnaires and medical records. Cox regression was used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (95% CIs). Analyses of sleep characteristics reported at the first follow-up interview included only participants who were breast cancer-free at time of follow-up interview. Over ∼7 years of follow-up, 2,736 breast cancer cases (invasive and ductal carcinoma in situ) were diagnosed. There was little evidence that usual sleep duration or other sleep characteristics were associated with breast cancer. However, relative to those with no difficulty sleeping, women who reported having difficulty sleeping ≥ 4 nights a week were at an increased risk of overall (HR = 1.32, 95% CI: 1.09–1.61) and postmenopausal breast cancer (HR = 1.51, 95% CI 1.24–1.85). Risk of ER+ invasive cancer was elevated for women who reported having a light or television on in the room while sleeping (HR = 1.20, 95% CI: 0.97–1.47) or who typically got less sleep than they needed to feel their best (HR = 1.21, 95% CI: 0.98–1.50). In our study, most sleep characteristics, including sleep duration, were not associated with an increased risk although higher risk was observed for some markers of inadequate or poor quality sleep.
D6.2 Interim Report on Exploitation
Creators: name: Berozashvili, Revaz
name: Castellanos, German
name: Armstrong, Joss
name: Bielsa, Guillermo
name: Gutiérrez Terán, Jesús
name: Sark, Vladica
name: Koffman, Israel
name: Globen, Baruch
name: Pérez-Romero, Jordi
name: Sallent Roig, José Oriol
name: Sánchez-González, Juan
name: Umbert Juliana, Anna
name: Catalan, Miguel
name: Municio, Esteban
name: Salvat Lozano, Josep Xavier
name: Ayala-Romero, Jose A.
name: van der Veen, Hans
name: Ghoraishi, Mir
Publisher: name: Zenodo
Year: 2024

description: This document, BeGREEN D6.2, is the “Interim Report on Exploitation”, reporting the work of BeGREEN Task 6.4.  It includes details about the innovation management methodology applied within BeGREEN and draws some initial conclusions and results obtained during the 18 months of the project. This report evolves the exploitation plan of BeGREEN D6.1 [1].

This document also provides an updated exploitation plan for individual Parties, and an updated joint exploitation plan. Particularly, it identifies and summarises the exploitable outcomes from the project. The methodologies for analysing these exploitable outcomes are as well described.

This document comprises 5 chapter. Following the Executive Summary, the following chapters are:

·       Chapter 1 introduces the document and provides the context of the innovation objectives defined in the BeGREEN Grant Agreement (GA).

·       Chapter 2 elaborates the project’s innovation goals, innovation methodology and innovation assessment.

·       Chapter 3 presents the exploitation strategy, methodology applied by each partner, and the value proposition and the Lean Canvases used by each partner.

·       Chapter 4 summarizes the main exploitable outcomes identified in BeGREEN and introduces updated individual plans and joint exploitation plans.

·       Chapter 5  presents an updated market analysis of the commercialization of the BeGREEN innovation results.

·       Chapter 6 is the conclusion and summary.

The exploitation goals of BeGREEN are consistent with the scope of the project SNS Stream A call SNS-2022-STREAM-A-01-01, of type RIA action, with results typically of TRL 3-4 (with some limited results of TRL 5) maturity, with significant additional innovation and commercialization efforts required, beyond the results of this project, for true commercial exploitation.
The association between metabolic health, obesity phenotype and the risk of breast cancer
Creators: name: Nichols, H.B
name: White, A.J
name: Sandler, D.P
name: O'Brien, K.M
name: Park, Y.-M.M
name: Weinberg, C.R
Publisher: name: Wiley-Liss Inc.
Year: 2017

description: Beyond the current emphasis on body mass index (BMI), it is unknown whether breast cancer risk differs between metabolically healthy and unhealthy normal weight or overweight/obese women. The Sister Study is a nationwide prospective cohort study. Data came from 50,884 cohort participants aged 35 to 74 years enrolled from 2003 through 2009. Cox proportional hazards models were used to estimate multivariable adjusted hazard ratios (HR) and 95% confidence intervals (CIs) for breast cancer risk. Metabolic abnormalities considered included: high waist circumference (≥88 cm); elevated blood pressure (≥130/85 mm Hg or antihypertensive medication); previously diagnosed diabetes or antidiabetic drug treatment; and cholesterol-lowering medication use. During follow-up (mean, 6.4 years), 1,388 invasive breast cancers were diagnosed at least 1 year after enrollment. Compared to women with BMI <25 kg/m2 with no metabolic abnormalities (metabolically healthy normal weight phenotype), women with a BMI <25 kg/m2 and ≥1 metabolic abnormality (metabolically unhealthy, normal weight phenotype) had increased risk of postmenopausal breast cancer (HR = 1.26, 95% CI: 1.01–1.56), as did women with a BMI ≥25 kg/m2 and no metabolic abnormalities (metabolically healthy overweight/obese phenotype) (HR = 1.24, 95% CI: 0.99–1.55). Furthermore, risk of postmenopausal breast cancer was consistently elevated in women with normal BMI and central obesity (normal weight central obesity phenotype) regardless of the criterion used to define central obesity, with HR for waist circumference ≥88 cm, waist circumference ≥80 cm, and waist-hip ratio ≥0.85 of 1.58, 95% CI: 1.02–2.46; 1.38, 95% CI: 1.09–1.75; and 1.38, 95% CI: 1.02–1.85, respectively. There was an inverse association between premenopausal breast cancer and metabolically healthy overweight/obese phenotype (HR = 0.71, 95% CI: 0.52–0.97). Our findings suggest that postmenopausal women who are metabolically unhealthy or have central adiposity may be at increased risk for breast cancer despite normal BMI.
Breast cancer and exposure to tobacco smoke during potential windows of susceptibility
Creators: name: DeRoo, L.A
name: Nichols, H.B
name: D’Aloisio, A.A
name: Sandler, D.P
name: White, A.J
Publisher: name: Springer International Publishing
Year: 2017

description: Purpose: An association between smoking and breast cancer is unresolved, although a higher risk from exposure during windows of susceptibility has been proposed. The objective of this prospective study was to evaluate the association between tobacco smoke and breast cancer with a focus on timing of exposure, especially during early life. Methods: Sister study participants (n = 50,884) aged 35–74 were enrolled from 2003 to 2009. Women in the United States and Puerto Rico were eligible if they were breast cancer-free but had a sister with breast cancer. Participants completed questionnaires on smoking and environmental tobacco smoke (ETS) exposure. Cox regression was used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (95% CIs) for breast cancer risk. Results: During follow-up (mean = 6.4 years), 1,843 invasive breast cancers were diagnosed. Neither active smoking nor adult ETS was associated with breast cancer risk. However, never smoking women exposed to ETS throughout their childhood had a 17% higher risk of breast cancer (95% CI 1.00–1.36) relative to those with no exposure. In utero ETS exposure was also associated with breast cancer (HR = 1.16, 95% CI 1.01–1.32) and the HR was most elevated for women born in earlier birth cohorts (<1940, HR = 1.44, 95% CI 1.02–2.02; 1940–1949, HR = 1.28, 95% CI 1.01–1.62). Conclusion: In utero ETS and ETS exposure during childhood and adolescence were associated with increased risk of breast cancer and associations varied by birth cohort.
Age- and treatment-related associations with health behavior change among breast cancer survivors
Creators: name: Anderson, C
name: Sabatino, S.A
name: Chunduri, M
name: Weinberg, C.R
name: Sandler, D.P
name: Nichols, H.B
name: Hodgson, M.E
name: Houck, K
name: Rodriguez, J.L
name: White, M.C
Publisher: name: Churchill Livingstone
Year: 2017

description: Objective The aim of this study was to identify demographic and treatment-related factors associated with health-promoting behavior changes after a breast cancer diagnosis. Changes in health behaviors were also evaluated according to weight, exercise, diet and alcohol consumption patterns before breast cancer diagnosis. Materials and methods We examined self-reported behavior changes among 1415 women diagnosed with breast cancer in the NIEHS Sister Study cohort. Women reported changes in exercising, eating healthy foods, maintaining a healthy body weight, drinking alcohol, smoking, getting enough sleep, spending time with family and friends, and participating in breast cancer awareness events. Results On average, women were 3.7 years from their breast cancer diagnosis. Overall, 20–36% reported positive changes in exercise, eating healthy foods, maintaining a healthy weight, or alcohol consumption. However, 17% exercised less. With each 5-year increase in diagnosis age, women were 11–16% less likely to report positive change in each of these behaviors (OR = 0.84–0.89; p < 0.05), except alcohol consumption (OR = 0.97; CI: 0.81, 1.17). Women who underwent chemotherapy were more likely to report eating more healthy foods (OR = 1.47; 95% CI 1.16–1.86), drinking less alcohol (OR = 2.01; 95% CI: 1.01, 4.06), and sleeping enough (OR = 1.41; 95% CI: 1.04, 1.91). The majority of women (50–84%) reported no change in exercise, eating healthy foods, efforts to maintain a healthy weight, alcohol consumption, sleep patterns, or time spent with family or friends. Conclusions Many women reported no change in cancer survivorship guideline-supported behaviors after diagnosis. Positive changes were more common among younger women or those who underwent chemotherapy.
title: répudiation
Creators: name: Centre De Recherches Historiques / Anthropologie Historique Du Long Moyen Âge
Publisher: name: EHESS (School for Advanced Studies in Social Sciences)
Year: 2019

description: Action de renvoyer quelqu'un (une femme, un serviteur) ; se distingue de destitution , qui suppose le retrait d'une charge officielle, et de divorce , utilisé seulement dans un contexte juridique spécifique.
Wild bootstrap seasonal unit root tests for time series with periodic non-stationary volatility
Creators: name: Cavaliere, Giuseppe
name: Skrobotov, Anton
name: A. M. Robert Taylor
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: We investigate the behaviour of the well-known HEGY (Hylleberg, Engle, Granger and Yoo, 1990, Journal of Econometrics, vol. 44, pp. 215–238) regression-based seasonal unit root tests in cases where the driving shocks can display periodic non-stationary volatility and conditional heteroskedasticity. Our set up allows for periodic heteroskedasticity, non-stationary volatility and (seasonal) GARCH as special cases. We show that the limiting null distributions of the HEGY tests depend, in general, on nuisance parameters which derive from the underlying volatility process. Monte Carlo simulations show that the standard HEGY tests can be substantially over-sized in the presence of such effects. As a consequence, we propose wild bootstrap implementations of the HEGY tests. Two possible wild bootstrap re-sampling schemes are discussed, both of which are shown to deliver asymptotically pivotal inference under our general conditions on the shocks. Simulation evidence is presented which suggests that our proposed bootstrap tests perform well in practice, largely correcting the size problems seen with the standard HEGY tests even under extreme patterns of heteroskedasticity, yet not losing finite sample relative to the standard HEGY tests.
Long-Term Satisfaction and Body Image After Contralateral Prophylactic Mastectomy
Creators: name: Sandler, D.P
name: Hodgson, M.E.
name: Nichols, H.B
name: Rodriguez, J.L
name: Anderson, C
name: Lee, C.N
name: Sabatino, S.A
name: Islam, J.Y
Publisher: name: Springer New York LLC
Year: 2017

description: Background: Contralateral prophylactic mastectomy (CPM) rates have been increasing in the US, and although high levels of satisfaction with CPM have been reported, few studies have evaluated the long-term effects on body image, comparing CPM with breast-conserving surgery (BCS) and unilateral mastectomy (UM). Methods: We analyzed responses from a survey of women with both a personal and family history of breast cancer who were enrolled in the Sister Study (n = 1176). Among women who underwent mastectomy, we examined satisfaction with the mastectomy decision, as well as variation in the use of reconstruction and experience of complications. Five survey items, evaluated individually and as a summed total score, were used to compare body image across surgery types (BCS, UM without reconstruction, CPM without reconstruction, UM with reconstruction, and CPM with reconstruction). Results: Participants were, on average, 3.6 years post-diagnosis at the time of survey (standard deviation 1.7). The majority of women (97% of CPM, 89% of UM) were satisfied with their mastectomy decision. Reconstruction was more common after CPM than after UM (70 vs. 47%), as were complications (28 vs. 19%). Body image scores were significantly worse among women who underwent CPM than among women who underwent BCS, with the lowest scores among women who underwent CPM without reconstruction. Conclusions: In our sample, most women were highly satisfied with their mastectomy decision, including those who elected to undergo CPM. However, body image was lower among those who underwent CPM than among those who underwent BCS. Our findings may inform decisions among women considering various courses of surgical treatment.