cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A multidisciplinary approach to improving the care and outcomes of patients with retinoblastoma at a pediatric cancer hospital in Egypt
Creators: name: Elzomor, Hossam
name: Taha, Hala
name: Radwa Nour
name: Aleieldin, Adel
name: M. Saad Zaghloul
name: Qaddoumi, Ibrahim
name: Alfaar, Ahmad S.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Background: Retinoblastoma poses a substantial burden in developing countries. We conducted this study to assess the effect of implementing a multidisciplinary approach and standardized protocols for treating pediatric patients with retinoblastoma at the Children’s Cancer Hospital Egypt (CCHE). Materials and Methods: In January 2011, the CCHE implemented standardized protocols for the diagnosis, treatment, and reporting of retinoblastoma cases. The hospital also introduced a new retinoblastoma management algorithm and data analysis system. In this study, we compared the pathologic features, tumor invasiveness, reporting, and survival of 276 pediatric patients who underwent enucleations of 290 eyes before or after the implementation of the retinoblastoma protocols. Results: Time to enucleation (indicating time needed for decision taking) decreased significantly within the neoadjuvant chemotherapy group for intraocular disease after January 2011 (68.7 ± 48 weeks vs. 47.3 ± 28.3 weeks; p < 0.05). Mean optic nerve stump length increased from 5.6 mm in the earlier period to 7.2 mm in the later period (p = 0.004). The overall quality of pathology reporting also improved during the later period. The probability of 3-year survival was significantly higher for patients during the later period (94.2% vs. 79.2%; p = 0.018). Conclusions: The implementation of standardized protocols and a multidisciplinary approach improved reporting; discrepancies in disease classification and the amount of missing data were reduced; and quality measures and prognostic capabilities of the team were substantially improved. Such established data-driven practice supports faster decision making to enucleate diseased eyes and save patients’ lives through providing measurable indicators.
Data Sharpening on Unknown Manifold
Creators: name: Kudo, Masaki
name: Naito, Kanta
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Marine Biology
subject: Cancer
subject: Science Policy

description: This paper is concerned with data sharpening technique in nonparametric regression under the setting where the multivariate predictor is embedded in an unknown low-dimensional manifold. Theoretical asymptotic bias is derived, which reveals that the proposed data sharpening estimator has a reduced bias compared to the usual local linear estimator. The asymptotic normality of the data sharpening estimator is also developed. It can be confirmed from simulation and applications to real data that the bias reduction for the data sharpening estimator supported on unknown manifold is evident.
Additional file 7 of Identification of distinct slow mode of reversible adaptation of pancreatic ductal adenocarcinoma to the prolonged acidic pH microenvironment
Creators: name: Wu, Tzu-Chin
name: Liao, Chien-Yu
name: Lu, Wei-Chien
name: Chang, Chuang-Rung
name: Tsai, Fang-Yu
name: Jiang, Shih-Sheng
name: Chen, Tsung-Hsien
name: Lin, Kurt Ming-Chao
name: Chen, Li-Tzong
name: Chang, Wun-Shaing Wayne
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Inorganic Chemistry
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 7: Table S4. List of significantly up-regulated differentially expressed genes associated with long-term adaptation of PDAC tumor cells to an acidic pHe microenvironment.
Additional file 2 of New insights from the biogas microbiome by comprehensive genome-resolved metagenomics of nearly 1600 species originating from multiple anaerobic digesters
Creators: name: Campanaro, Stefano
name: Treu, Laura
name: Rodriguez-R, Luis M.
name: Kovalovszki, Adam
name: Ziels, Ryan M.
name: Maus, Irena
name: Xinyu Zhu
name: Kougias, Panagiotis G.
name: Basile, Arianna
name: Luo, Gang
name: Schlüter, Andreas
name: Konstantinidis, Konstantinos T.
name: Angelidaki, Irini
Publisher: name: figshare
Year: 2020
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional file 2. Supporting methods containing detailed process for assembly, binning and taxonomic assignment. This file includes also supplementary figures (S1 to S5) and Supplementary Table S1, with the number of replication origins identified in the archaeal genomes.
Body mass index is related with the presence of syndesmophyte in axial spondyloarthritis: Data from the Korean College of Rheumatology BIOlogics (KOBIO) registry
Creators: name: Seong-Kyu Kim
name: Jung-Yoon Choe
name: Shin-Seok Lee
name: Kichul Shin
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Hematology
subject: Computational Biology

description: Objective: We investigated whether body mass index (BMI) is associated with parameters of disease activity and clinical manifestations in axial spondyloarthritis (axSpA). Methods: Demographic, clinical, and radiological features and disease activity indexes from 789 axSpA patients (619 males and 170 females) were obtained from the Korean College of Rheumatology BIOlogics (KOBIO) registry. BMI (kg/m2) was classified into normal (BMI <23.0), overweight (23.0 ≤ BMI <25.0), and obese (BMI ≥25.0). Disease activity indexes included Bath ankylosing spondylitis disease activity index (BASDAI), erythrocyte sediment rate (ESR), C-reactive protein (CRP), and ankylosing spondylitis disease activity score (ASDAS). Results: The mean BMI in patients with axSpA was 23.3 ± 3.5. 50.2% of all patients were overweight or obese. Overweight/obese patients had more syndesmophyte and less peripheral arthritis than those in normal BMI patients (p p p p = 0.002) Conclusions: Our results imply that increased BMI is significantly associated with the presence of syndesmophyte, but not with disease activity in axSpA.
Synthesis of pyrimido[4′,5′:5,6][1,4]dithiepino[2,3-b]quinoxalines: Derivatives of a novel seven membered ring system
Creators: name: Firoozi, Neda
name: Bakavoli, Mehdi
name: Eshghi, Hossein
name: Ramazanian, Navid
name: Akbarzadeh, Marziyeh
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Molecular Biology
subject: Neuroscience
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: A convenient and efficient procedure for the synthesis of tetracyclic dithiepin derivatives is described through the condensation reaction of 2,4-dichloro-5-(chloromethyl)-6- methylpyrimidine and quinoxaline-2,3-dithiol followed by treatment with secondary amines.
Additional file 9: of Direct measurement of pervasive weak repression by microRNAs and their role at the network level
Creators: name: Ma, Fuqiang
name: Lin, Pei
name: Chen, Qingjian
name: Lu, Xuemei
name: Zhang, Yong
name: Wu, Chung-I
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: Table S4. Real-time polymerase chain reaction primers used for mRNA quantification. (PDF 198 kb)
title: 02_1034
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Additional file 8 of Identification of distinct slow mode of reversible adaptation of pancreatic ductal adenocarcinoma to the prolonged acidic pH microenvironment
Creators: name: Wu, Tzu-Chin
name: Liao, Chien-Yu
name: Lu, Wei-Chien
name: Chang, Chuang-Rung
name: Tsai, Fang-Yu
name: Jiang, Shih-Sheng
name: Chen, Tsung-Hsien
name: Lin, Kurt Ming-Chao
name: Chen, Li-Tzong
name: Chang, Wun-Shaing Wayne
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Inorganic Chemistry
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 8: Table S5. List of significantly down-regulated and differentially expressed genes associated with long-term adaptation of PDAC tumor cells to acidic pHe microenvironment.
Additional file 1 of Expansion of the prime editing modality with Cas9 from Francisella novicida
Creators: name: Oh, Yeounsun
name: Lee, Wi-jae
name: Hur, Junho K.
name: Song, Woo Jeung
name: Lee, Youngjeon
name: Kim, Hanseop
name: Gwon, Lee Wha
name: Kim, Young-Hyun
name: Park, Young-Ho
name: Kim, Chan Hyoung
name: Lim, Kyung-Seob
name: Song, Bong-Seok
name: Huh, Jae-Won
name: Kim, Sun-Uk
name: Jun, Bong-Hyun
name: Jung, Cheulhee
name: Lee, Seung Hwan
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Plant Biology

description: Additional file 1: Figure S1. Analysis of the cleavage point of FnCas9 and SpCas9. Figure S2. Shared target sequence and editing method by using SpCas9(H840A)-RT and FnCas9(H969A)-RT. Figure S3. Various methods of prime editor delivery by using SpCas9(H840A)-RT or FnCas9(H969A)-RT expression plasmids. Figure S4. The target sequence and NGS analysis results commonly edited by SpCas9(H840A)-RT or FnCas9(H969A)-RT. Figure S5. Cell diversity experiment of prime editing using FnCas9(H969A)-RT. Figure S6. Comparative analysis of nickase activity of SpCas9(H840A)-RT and FnCas9(H969A)-RT. Figure S7. Targeting of multiple loci for direct comparison between SpCas9(H840A)-RT and FnCas9(H969A)-RT based prime editing. Figure S8. Comparative analysis of off-target editing of SpCas9(H840A)-RT and FnCas9(H969A)-RT based on in-silico predicted sites. Figure S9. Multiplexed prime editing with SpCas9(H840A)-RT and FnCas9(H969A)-RT system. Figure S10. Expansion of the range of prime editing in EMX1 locus by FnCas9(H969A)-RT. Figure S11. Result of the prime editing in target sequence induced by FnCas9(H969A)-RT. Figure S12. Expansion of the targetable range by prime editing with FnCas9(H969A)-RT or RHA-FnCas9(H969A)-RT.
Phosphate-assisted phytoremediation of arsenic by Brassica napus and Brassica juncea: Morphological and physiological response
Creators: name: Niazi, Nabeel Khan
name: Bibi, Irshad
name: Fatimah, Ayesha
name: Shahid, Muhammad
name: Javed, Muhammad Tariq
name: Hailong Wang
name: Ok, Yong Sik
name: Bashir, Safdar
name: Murtaza, Behzad
name: Saqib, Zulfiqar Ahmad
name: Shakoor, Muhammad Bilal
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology
subject: Computational Biology

description: In this study, we examined the potential role of phosphate (P; 0, 50, 100 mg kg−1) on growth, gas exchange attributes, and photosynthetic pigments of Brassica napus and Brassica juncea under arsenic (As) stress (0, 25, 50, 75 mg kg−1) in a pot experiment. Results revealed that phosphate supplementation (P100) to As-stressed plants significantly increased shoot As concentration, dry biomass yield, and As uptake, in addition to the improved morphological and gas exchange attributes and photosynthetic pigments over P0. However, phosphate-assisted increase in As uptake was substantially (up to two times) greater for B. napus, notably due to higher shoot As concentration and dry biomass yield, compared to B. juncea at the P100 level. While phosphate addition in soil (P100) led to enhanced shoot As concentration in B. juncea, it reduced shoot dry biomass, primarily after 50 and 75 mg kg−1 As treatments. The translocation factor and bioconcentration factor values of B. napus were higher than B. juncea for all As levels in the presence of phosphate. This study demonstrates that phosphate supplementation has a potential to improve As phytoextraction efficiency, predominantly for B. napus, by minimizing As-induced damage to plant growth, as well as by improving the physiological and photosynthetic attributes.
Supplementary Data File 1; Sequence of pGTF-CytB: Development and application of an eDNA method to detect the critically endangered Trinidad golden tree frog (Phytotriades auratus) in bromeliad phytotelmata
Creators: name: Hoskisson, Paul A
Publisher: name: figshare
Year: 2017
Subjects: subject: 60806 Animal Physiological Ecology
subject: FOS: Biological sciences

description: Supplementary Data File 1
 Sequence of pGTF-CytB (Brozio et al., 2017)Phytotriades auratus CytB gene fragment is the first 390 bp (in Upper case), followed by 2450 bp of pEX-A (MWG Eurofins).
Additional file 2 of Expansion of the prime editing modality with Cas9 from Francisella novicida
Creators: name: Oh, Yeounsun
name: Lee, Wi-jae
name: Hur, Junho K.
name: Song, Woo Jeung
name: Lee, Youngjeon
name: Kim, Hanseop
name: Gwon, Lee Wha
name: Kim, Young-Hyun
name: Park, Young-Ho
name: Kim, Chan Hyoung
name: Lim, Kyung-Seob
name: Song, Bong-Seok
name: Huh, Jae-Won
name: Kim, Sun-Uk
name: Jun, Bong-Hyun
name: Jung, Cheulhee
name: Lee, Seung Hwan
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Plant Biology

description: Additional file 2. Review history.
3D-virtual geological exploration of the delta units, Jezero crater, Mars.
Creators: name: Borchert, Alexander
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Mars
subject: Geology
subject: FOS: Earth and related environmental sciences
subject: Remote Sensing
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::550 Geowissenschaften
subject: 500 Naturwissenschaften und Mathematik::520 Astronomie::523 Einzelne Himmelskörper und Himmelsphänomene

description: The first long-distance observations made by Perseverance from the Kodiak butte con- firmed Gilbert-type delta deposition within a closed-lake system in Jezero crater, Mars. Several outcrops at the delta proper were also imaged later during science campaign but their geology and potential relationship to Kodiak needed to be explored. In this thesis, Perseverance image data with a focus on Mastcam-Z and Supercam was used in digital outcrop modeling, applying the Structure-From-motion (SFM) photogram- metry software Agisoft Metashape and georeferenced with SPICE-derived position and orientation. The digital outcrop models (DOMs) were analyzed in the Pro3D software, extracting dip and strike measurements as well as scale bars for determining 2D-clast size-frequency distributions with the ImageJ software. Seven high-resolution, textured and accurate digital outcrop models were created. Evidence gathered from the DOMs shows sedimentary facies associated with Gilbert-type delta stratal architectures. Fore- set and lower foreset facies were identified at the outcrops Franklin Cliff, Whale Moun- tain, Kodiak and Scarp A. Topset facies were found at every outcrop, except Scarp D. “Whale Mountain“ also displays a prominent mouth bar deposit. Six clast samples were collected, all associated with a fluvial origin. Three samples were identified as channel base deposits in a topset environment, one interpreted as a foreset debrite, one debris flow, and one high-energy flood conglomerate. Topset-foreset boundaries differ in alti- tude between outcrops, suggesting different phases of delta progradation. Inferred paleo flows from Whale Mountain and Franklin Cliff link those to the delta strata found at Kodiak, further indicating that the butte was once part of the delta. This thesis demon- strates how digital outcrop models can be used to conduct virtual fieldwork also in the remote environment of Mars.
Additional file 1 of One-year survival of patients admitted for sepsis to intensive care units in Colombia
Creators: name: Oliveros, Henry
name: Tuta-Quintero, Eduardo
name: Piñeros, Mariana
name: Guesguan, Alexander
name: Reyes, Luis F.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Supplementary Material 1
MOESM1 of miR-MaGiC improves quantification accuracy for small RNA-seq
Creators: name: Russell, Pamela
name: Vestal, Brian
name: Shi, Wen
name: Rudra, Pratyaydipta
name: Dowell, Robin
name: Radcliffe, Richard
name: Saba, Laura
name: Kechris, Katerina
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology

description: Additional file 1. Additional materials, methods, figures, and tables.
Additional file 1 of Barriers to help-seeking from healthcare professionals amongst women who experience domestic violence - a qualitative study in Sri Lanka
Creators: name: Silva, Tharuka
name: Agampodi, Thilini
name: Evans, Maggie
name: Knipe, Duleeka
name: Rathnayake, Abey
name: Rajapakse, Thilini
Publisher: name: figshare
Year: 2022
Subjects: subject: Sociology
subject: FOS: Sociology

description: Additional file 1. Topic guide to interview women who experience DV.
Sick leave among parents of children with cancer – a national cohort study
Creators: name: Hjelmstedt, Sofia
name: Norberg, Annika Lindahl
name: Montgomery, Scott
name: Myrberg, Ida Hed
name: Hovén, Emma
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Background: Due to psychological distress and an increased care burden, parents of children diagnosed with cancer may face a higher risk of sickness absence from work. The objective of this study was to examine the association of childhood cancer with parents’ sick leave. Material and methods: The sample comprised 3626 parents of 1899 children diagnosed with cancer in Sweden during 2004–2009, and a matched control group of parents (n = 34 874). Sick leave was measured as number of days with sickness benefit, retrieved from national registries. Logistic and negative binomial regression models were used to compare outcomes with parents from the control cohort. Results: The risk of sick leave was statistically significantly higher up to six years following a child’s cancer diagnosis. The increase in number of days with sickness benefit was most pronounced the year after diagnosis. Although mothers’ sick leave prevalence was higher, the increase in risk relative to control parents was similar for mothers and fathers. Bereavement was associated with a heightened risk of sick leave, especially on the year of the child’s death. Conclusions: Findings confirm that mothers and fathers of children diagnosed with cancer are at higher risk of sickness absence from work, with particularly pronounced risk among bereaved parents. Acquisition of further knowledge is warranted regarding possibilities and constraints of parents trying to combine their work life with caring for both their child and themselves.
Additional file 2 of Suspected clinical chorioamnionitis with peak intrapartum temperature <380C: the prevalence of confirmed chorioamnionitis and short term neonatal outcome
Creators: name: Vellamgot, Anvar Paraparambil
name: Salameh, Khalil
name: Habboub, Lina Hussain M.
name: Pattuvalappil, Rajesh
name: Elkabir, Naser Abulgasim
name: Siam, Yousra Shehada
name: Khatib, Hakam
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: Additional file 2.
Combined aphasia and apraxia of speech treatment (CAAST): Systematic replications in the development of a novel treatment
Creators: name: Wambaugh, Julie L.
name: Wright, Sandra
name: Mauszycki, Shannon C.
name: Nessler, Christina
name: Bailey, Dallin
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Purpose: The purpose of this investigation was to examine the effects of a modified version of a newly developed therapy for aphasia and acquired apraxia of speech (AOS), Combined Aphasia and Apraxia of Speech Treatment (CAAST). Method: Four speakers with chronic AOS and aphasia received CAAST in the context of multiple baseline designs. Dependent variables included language measures (i.e. production of correct information units (CIUs)) and speech production measures (i.e. speech intelligibility and percent correct consonants (PCC) in sentence repetition). Result: Three of the participants demonstrated improved CIU production with treated picture sets and two also demonstrated generalization to untreated sets. All participants achieved substantially increased CIU production in an untrained discourse context. Speech intelligibility increased for three of the participants and increases in PCC were observed for all of the participants at two weeks post-treatment. However, PCC improvements were maintained for only two of the speakers at six weeks post-treatment. Conclusion: The revised CAAST protocol was associated with improved changes in speech and generalization across contexts in comparison to the previous iteration of CAAST. However, focus on sentence production in generalization practice may have been detrimental to CIU production for one participant.
title: Deep Learning methods for partial to whole object registration in mixed reality guided liver surgery - preliminary experiments
Creators: name: Reinfurt, Guido
Publisher: name: Hochschule für Angewandte Wissenschaften Landshut
Year: 2024

description: This work primarily focuses on improving registration procedures within augmented reality (AR) applications, by analyzing the reliability of point cloud reconstruction as a preprocessing step. Therefore, a state-of-the-art, transformer base network is utilized. For the training process a comprehensive dataset specifically designed for training deep learning models is created. This dataset will be tailored to the task of reconstructing partial liver views for augmented reality guidance in medical applications. The validation process for this dataset will be two-fold:

• Deep Learning Network Training: The created dataset will be used to train a state-of-the-art deep learning network, specifically a transformer-based model, the “PoinTr”-network. This training will evaluate the dataset's effectiveness in facilitating accurate point cloud reconstruction.

• Testing with Real-World Scenarios: A separate testing dataset, meticulously designed to reflect various real-world conditions encountered in AR guidance, such as variations in point cloud density, occlusions, and sensor noise, will be used to assess the performance of the trained model. This evaluation will analyze the model's ability to generate accurate reconstructions under diverse and potentially challenging scenarios.
Additional file 1: of Evidence for the use of complementary and alternative medicines during fertility treatment: a scoping review
Creators: name: Miner, Skye
name: Robins, Stephanie
name: Zhu, Yu
name: Keeren, Kathelijne
name: Gu, Vivian
name: Read, Suzanne
name: Zelkowitz, Phyllis
Publisher: name: figshare
Year: 2018
Subjects: Medicine
Molecular Biology
Pharmacology
Biotechnology
Developmental Biology

description: Definitions of CAM Methods-Definition of CAM methods analyzed. (DOCX 14 kb)
Additional file 1 of HDAC class I inhibitor domatinostat sensitizes pancreatic cancer to chemotherapy by targeting cancer stem cell compartment via FOXM1 modulation
Creators: name: Roca, Maria Serena
name: Moccia, Tania
name: Iannelli, Federica
name: Testa, Cristina
name: Vitagliano, Carlo
name: Minopoli, Michele
name: Camerlingo, Rosa
name: De Riso, Giulia
name: De Cecio, Rossella
name: Bruzzese, Francesca
name: Conte, Mariarosaria
name: Altucci, Lucia
name: Di Gennaro, Elena
name: Avallone, Antonio
name: Leone, Alessandra
name: Budillon, Alfredo
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 1: Supplementary Table S1. Pancreatic cancer cells sensitivity. Supplementary Table S2. Screening domatinostat in combination with chemotherapeutics on cell proliferation by SRB assay and Calcusyn software. Supplementary Table S3. Screening domatinostat in combination with chemotherapeutics on cell proliferation by SRB assay and Calcusyn software. Supplementary Table S4. Screening domatinostat in combination with chemotherapeutics on cell proliferation by SRB assay and Calcusyn software. Supplementary Table S5. Screening domatinostat in combination with chemotherapeutics on cell proliferation by SRB assay and Calcusyn software. Supplementary Table S6. Domatinostat modulates FOXM1 activity. Supplementary Table S7. Critical FOXM1 role in pancreatic cancer patients. Supplementary Figure S1. Chemotherapy effect on pancreatic cancer cells. Supplementary Figure S2. Domatinostat plus gemcitabine/taxol combination induces Annexin-V exposure. Supplementary Figure S3. Domatinostat plus gemcitabine/taxol combination induces cell cycle perturbation and a clear block in phase S. Supplementary Figure S4. Pancreatic cancer cells enriched in stem-cell features, culturing model validation. Supplementary Figure S5. Domatinostat effects on CSC population. Supplementary Figure S6. The effect of domatinostat on PDAC spheroid cultures. Supplementary Figure S7. Domatinostat effects on FOXM1 expression. Supplementary Figure S8. Domatinostat modulates FOXM1 activity. Supplementary Figure S9. A network analysis revealed FOXM1 as upstream regulator of significant domatinostat-modulated proteins involved in stemness, oxidative stress and DNA repair. Supplementary Figure S10. Critical FOXM1 role in pancreatic cancer patients. Supplementary Figure S11. FOXM1 expression in transfected cells. Supplementary Figure S12. Domatinostat modulates FOXM1 activity. Supplementary Figure S13. Domatinostat does not exert toxic effect alone and in combination in vivo. Supplementary Figure S14. Domatinostat synergistically improves overall survival of PANC1 mice affecting FOXM1 and OCT4 expression.
Additional file 2: of Evidence for the use of complementary and alternative medicines during fertility treatment: a scoping review
Creators: name: Miner, Skye
name: Robins, Stephanie
name: Zhu, Yu
name: Keeren, Kathelijne
name: Gu, Vivian
name: Read, Suzanne
name: Zelkowitz, Phyllis
Publisher: name: figshare
Year: 2018
Subjects: Medicine
Pharmacology
Biotechnology
Developmental Biology
Science Policy

description: CAM Review Sheet-Copy of the Google review sheet used to record the information from the articles. (PDF 90 kb)
A small variation in average particle size of PLGA nanoparticles prepared by nanoprecipitation leads to considerable change in nanoparticles’ characteristics and efficacy of intracellular delivery
Creators: name: Sahin, Adem
name: Gunes Esendagli
name: Firat Yerlikaya
name: Secil Caban-Toktas
name: Digdem Yoyen-Ermis
name: Horzum, Utku
name: Yesim Aktas
name: Khan, Mansoor
name: Couvreur, Patrick
name: Yilmaz Capan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: In this study, it was aimed to investigate characteristics and intracellular delivery of two different-sized PLGA nanoparticles in ouzo region by considering number of nanoparticles. To determine the effect of formulation parameters on average particle size, Dil labeled nanoparticles were prepared using a three-factor, two-level full factorial statistical experimental design. PLGA230 (230.8 ± 4.32 nm) and PLGA160 (157.9 ± 6.16 nm) nanoparticles were obtained by altering polymer amount based on experimental design results and characterized. Same number of PLGA230 and PLGA160 nanoparticles per cell were applied onto HEK293 cells; then, cytotoxicity, uptake kinetics and mechanism were evaluated by flow cytometry and fluorescent microscopy. Also same weight of PLGA230 and PLGA160 nanoparticles were applied and cellular uptake of these nanoparticles was evaluated. It was found that PLGA230 nanoparticles had higher encapsulation efficiency and slower dye release compared to PLGA160 nanoparticles. When they were applied at same counts per cell, PLGA230 nanoparticles displayed faster and higher intracellular dye transfer than PLGA160 nanoparticles. On the other hand, PLGA160 appeared to be a more effective vehicle than PLGA230 when applied at the same weight concentration. It was also shown that for both nanoparticles, HEK293 cells employed macropinocytic, caveolae- and clathrin-mediated endocytic pathways.
Additional file 1 of Evaluation of photoreceptor-directed fibroblasts derived from retinitis pigmentosa patients with defects in the EYS gene: a possible cost-effective cellular model for mechanism-oriented drug
Creators: name: Rai, Dilip
name: Iwanami, Masaki
name: Takahashi, Yoriko
name: Komuta, Yukari
name: Aoi, Noriyuki
name: Umezawa, Akihiro
name: Seko, Yuko
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Table S1. EYS-RP-associated pathways.
Additional file 1: of Plasmodium yoelii infection inhibits murine leukaemia WEHI-3 cell proliferation in vivo by promoting immune responses
Creators: name: Tong, Zhen-Zhen
name: Fang, Zheng-Ming
name: Zhang, Qi
name: Zhan, Yun
name: Zhang, Yue
name: Jiang, Wan-Fang
name: Hou, Xiao
name: Li, Yong-Long
name: Wang, Ting
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Multilingual abstracts in the five official working languages of the United Nations. (PDF 492 kb)
CHALLENGES IN VOCABULARY ACQUISITION FOR ENGLISH LEARNERS
Creators: name: Maksumova, Mavludakhon
Publisher: name: Zenodo
Year: 2024

description: Vocabulary acquisition presents significant challenges for non-native English learners due to the vast number of words, multiple meanings, and complex usage contexts. This paper explores common vocabulary learning difficulties, including polysemy, collocations, and idiomatic expressions. The study highlights the impact of these challenges on comprehension and language proficiency, particularly for learners from diverse linguistic backgrounds. Strategies for overcoming vocabulary acquisition difficulties are discussed, emphasizing the role of context and active learning. The research underscores the importance of targeted vocabulary instruction and practice in enhancing English fluency.
Additional file 1 of Real-world data reveals the complexity of disease modifying anti-rheumatic drug treatment patterns in juvenile idiopathic arthritis: an observational study
Creators: name: Grazziotin, Luiza R.
name: Currie, Gillian
name: Twilt, Marinka
name: Ijzerman, Maarten J.
name: Kip, Michelle M. A.
name: Koffijberg, Hendrik
name: Benseler, Susanne M.
name: Swart, Joost F.
name: Vastert, Sebastiaan J.
name: Wulffraat, Nico M.
name: Yeung, Rae S. M.
name: Marshall, Deborah A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1: Figure S1. Inverted Kaplan-Meier showing time (years) from first visit to the Pediatric Rheumatology Clinic to A) start the first c-DMARD and B) start the first b-DMARD.
Additional file 1: of Characterization of a new apple luteovirus identified by high-throughput sequencing
Creators: name: Liu, Huawei
name: Wu, Liping
name: Nikolaeva, Ekaterina
name: Peter, Kari
name: Liu, Zongrang
name: Mollov, Dimitre
name: Cao, Mengji
name: Li, Ruhui
Publisher: name: figshare
Year: 2018
Subjects: subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Primers used in this study. (DOCX 13Â kb)
Additional file 1 of Mitigating psychological distress in healthcare workers as COVID-19 waves ensue: a repeated cross-sectional study from Jordan
Creators: name: Obeidat, Nour A.
name: Dodin, Yasmeen I.
name: Hawari, Feras I.
name: Albtoosh, Asma S.
name: Manasrah, Rasha M.
name: Mansour, Asem H.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Mitigating psychological distress in healthcare workers as COVID-19 waves ensue: a repeated cross-sectional study from Jordan
Additional file 1 of Exploring the potential of artificial intelligence to enhance the writing of english academic papers by non-native english-speaking medical students - the educational application of ChatGPT
Creators: name: Li, Jiakun
name: Zong, Hui
name: Wu, Erman
name: Wu, Rongrong
name: Peng, Zhufeng
name: Zhao, Jing
name: Yang, Lu
name: Xie, Hong
name: Shen, Bairong
Publisher: name: figshare
Year: 2024
Subjects: subject: Linguistics
subject: FOS: Languages and literature

description: Supplementary Material 1
Analysis of measured isotopic compositions by CASMO5 coupled with a JENDL-4.0 base library for irradiated fuel of light water reactors
Creators: name: Yamamoto, Toru
name: Sakai, Tomohiro
name: Iwahashi, Daiki
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Plant Biology

description: Measured isotopic compositions of UO2 and MOX fuel samples taken from irradiated light water reactor fuel assemblies were analyzed by CASMO5 coupled with a JENDL-4.0 base library to assess the uncertainties in the calculated isotopic compositions on heavy and fission product nuclides. The burnup calculations for the analysis were performed based on a single-assembly model taking into account the detail fuel assembly specifications and irradiation histories. For the MOX fuel samples, a multiple-assembly model was also adopted taking into account the effect of the surrounding UO2 fuel assemblies. The average and standard deviation of the biases (C/E − 1's (here C and E are calculated and measured results, respectively)) were calculated for each nuclide separately on the PWR and BWR UO2 fuel samples. The averaged biases for 235U, 236U, 239Pu, 240Pu, 241Pu and 242Pu were 2.7%, −0.9%, 0.3%, 0.7%, −2.4% and −1.7% for PWR UO2 samples, and 6.7%, −1.5%, 2.5%, −0.6%, 0.4% and −0.1% for BWR UO2 samples, respectively. The biases with the single-assembly model on the MOX fuel samples showed large positive values of 239Pu, and application of the multiple-assembly model reduced the biases as reported in our previous studies.
title: Necessity and coercion in Scots criminal law: a critical analysis
Creators: name: Barclay, Grant
Publisher: name: University of Glasgow
Year: 2022

description: This thesis provides a critical analysis of the substantive defences of necessity and coercion in Scots law. These are affirmative defences which do not deny the commission of the crime charged, but instead offer an explanation as to why the accused should nevertheless escape criminal liability. The approach taken to these defences in Scots law has tended to appear fragmented and unprincipled, with a strong focus on their limitations rather than their underlying rationale, such that the basis for exculpation is unclear. This in turn has ramifications for our understanding of the relationship between these two defences: necessity and coercion are seemingly distinguished by an arbitrary appeal to the nature of the threat and whether the accused ‘chose’ the crime they committed. With the above issues identified, this thesis proceeds with the following aims: 1) to conduct a historical (and comparative, where appropriate) review of necessity and coercion to discover what principles or factors shape the current rules for these defences in Scotland; 2) to explore the normative basis for exculpation when persons are forced to commit offences under extreme pressure and/or emergency, based on the emerging concepts of a constrained will and constrained choice; and 3) to determine how this normative understanding and division of the bases for exculpation might provide a more principled approach to the necessity and coercion defences in Scots law than presently exists. This thesis concludes that necessity and coercion should exculpate based on a normative distinction focused on whether the actor suffered from a constrained choice (such that they tried to do the best in unfavourable circumstances) versus a constrained will (i.e. normal reasoning has been impaired by an emotional reaction, caused by the circumstances). An extensive analysis of emotions in criminal law defences is undertaken in support of this argument, highlighting that conduct undertaken in emotion does not vitiate capacity and is thus an appropriate site for moral (and hence legal) blame. This new framework for necessity and coercion is thereafter utilised to reconsider the core requirements of these defences in contemporary Scots law: that the threat be immediate; and that the threat be of death or serious injury. This re-examination reveals that the immediacy requirement in both defences should be replaced with one focused on the reasonableness of the response, and that the scope for coercion, understood as a constrained will, may be widened to include offences committed while suffering from a deprivation of liberty.
Additional file 1: of Clinicopathological features, surgical strategy and prognosis of duodenal gastrointestinal stromal tumors: a series of 300 patients
Creators: name: Liu, Zhen
name: Zheng, Gaozan
name: Liu, Jinqiang
name: Liu, Shushang
name: Xu, Guanghui
name: Wang, Qiao
name: Guo, Man
name: Lian, Xiao
name: Zhang, Hongwei
name: Feng, Fan
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Information Systems not elsewhere classified
subject: Cancer

description: Table S1. The comparison of clinicopathological features of duodenal GISTs between our center and published data. Table S2. The comparison of clinicopathological features of duodenal GISTs between published data and the entire cohort. Figure S1. The comparison of survival. We analyzed our own data (37 cases) and compared to the published combined data (263 cases). Then compared the 263 cases to the total combined 300 cases. The results showed that there was no significant difference in the results of the two comparisons. (DOCX 7148Â kb)
Additional file 1 of Real-world effectiveness of fremanezumab in migraine patients initiating treatment in the United States: results from a retrospective chart study
Creators: name: Driessen, Maurice T.
name: Cohen, Joshua M.
name: Patterson-Lomba, Oscar
name: Thompson, Stephen F.
name: Seminerio, Michael
name: Carr, Karen
name: Totev, Todor I.
name: Sun, Rochelle
name: Yim, Erica
name: Mu, Fan
name: Ayyagari, Rajeev
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1. Clinician Characteristics.
Additional file 2 of Real-world effectiveness of fremanezumab in migraine patients initiating treatment in the United States: results from a retrospective chart study
Creators: name: Driessen, Maurice T.
name: Cohen, Joshua M.
name: Patterson-Lomba, Oscar
name: Thompson, Stephen F.
name: Seminerio, Michael
name: Carr, Karen
name: Totev, Todor I.
name: Sun, Rochelle
name: Yim, Erica
name: Mu, Fan
name: Ayyagari, Rajeev
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 2. Effectiveness outcomes by proportion of patients with ≥30% reduction from baseline in MMD: A) total population; B) dosing schedule subgroups; C) prior treatment failures subgroups.
Additional file 3 of Real-world effectiveness of fremanezumab in migraine patients initiating treatment in the United States: results from a retrospective chart study
Creators: name: Driessen, Maurice T.
name: Cohen, Joshua M.
name: Patterson-Lomba, Oscar
name: Thompson, Stephen F.
name: Seminerio, Michael
name: Carr, Karen
name: Totev, Todor I.
name: Sun, Rochelle
name: Yim, Erica
name: Mu, Fan
name: Ayyagari, Rajeev
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 3. Effectiveness outcomes by proportion of patients with ≥75% reduction from baseline in MMD: A) total population; B) dosing schedule subgroups; C) prior treatment failures subgroups.