cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Recommendations of the Standing Committee on Vaccination (STIKO) at the Robert Koch Institute – 2017/2018
Creators: name: Koch-Institut, Robert
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2017
Subjects: subject: STIKO
subject: Vaccination
subject: 610 Medizin

description: The Standing Committee on Vaccination (STIKO) is an independent expert committee, consisting of 12 to 18 members, as stipulated in the Infection Against Protection Law [Infektionsschutzgesetz (IfSG)]. The members are appointed by the German Federal Ministry of Health in consultation with the federal state health authorities for a period of 3 years. In accordance with the IfSG the committee provides recommendations on vaccinations and other measures for the specific prophylaxis of communicable diseases. When developing a new vaccination recommendation the STIKO conducts a medical and epidemiological risk-benefit assessment based on the best available evidence. This means beyond individual aspects the benefit of the vaccination at population level (e. g. expected epidemiological effects of the vaccination) is taken into account. STIKO recommendations serve the federal health authorities as a basis for their public recommendations. Following Volume V of the Social Insurance Code ([Sozialgesetzbuch Fünftes Buch (SGB V)] the STIKO recommendations are also the basis for the decision of the Joint National committee [Gemeinsamer Bundesausschuss (G-BA)] whether the costs of the vaccination are covered by the statutory health insurance. Vaccinations are among the most effective and significant medical measures. Modern vaccines are well tolerated, and irreversible serious adverse events (SAE) are observed only in very rare cases. The immediate goal of vaccination is to protect an individual from a specific disease. Given a high level of acceptance within the population high vaccination coverage rates can be attained. Consequently, it is possible to achieve regional elimination of single pathogens, and eventually to eradicate them worldwide. Elimination of measles, rubella, and poliomyelitis are declared and achievable goals of national and international health policy. In Germany vaccinations and other means of specific prophylaxis are “publicly recommended” by the health authorities of the federal states on the basis of the STIKO recommendations according to § 20 (3) IfSG]. Compensation of vaccineinduced injury caused by “publicly recommended” vaccinations is assured by the federal states.
Additional file 2 of Unfinished nursing care in healthcare settings during the COVID-19 pandemic: a systematic review
Creators: name: Bayram, Aysun
name: Chiappinotto, Stefania
name: Palese, Alvisa
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Cancer

description: Supplementary Material 2
Inanspruchnahme von Krankenhausbehandlungen in Deutschland
Creators: name: Prütz, Franziska
name: Rommel, Alexander
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2017
Subjects: subject: DEUTSCHLAND
subject: GESUNDHEITSMONITORING
subject: ERWACHSENE
subject: INANSPRUCHNAHME
subject: KRANKENHAUS
subject: 610 Medizin

description: Die stationäre Versorgung ist eine wichtige Säule des Gesundheitssystems. Daten aus Gesundheitssurveys ermöglichen die Darstellung der stationären Inanspruchnahme aus Sicht der Patientinnen und Patienten sowie die Verknüpfung mit sozialen und anderen Einflussfaktoren. In der Studie GEDA 2014/2015-EHIS wurde der Indikator „Krankenhausaufenthalt in den letzten 12 Monaten“ bei Erwachsenen erhoben. 16,9 % der Frauen und 15,3 % der Männer waren mindestens einmal in den letzten 12 Monaten im Krankenhaus. Die Inanspruchnahme von Krankenhausbehandlungen ist altersabhängig: Im Alter ab 65 Jahren hatten 25,9 % der Frauen und 25,8 % der Männer mindestens einen Krankenhausaufenthalt in den letzten 12 Monaten. Es zeigen sich im Hinblick auf die Inanspruchnahme stationärer Behandlung keine wesentlichen Geschlechterunterschiede, außer in der Alters gruppe 18 bis 29 Jahre: hier war ein Krankenhausaufenthalt bei Frauen häufiger als bei Männern. Eine höhere stationäre Inanspruchnahme in der unteren Bildungsgruppe besteht vor allem im mittleren Lebensalter.
Schnelltest-Diagnostik sexuell übertragbarer Infektionen in niedrigschwelligen Einrichtungen
Creators: name: Meyer, Thomas
name: Schüttler, Christian G.
name: Straube, Eberhard
name: Roß, R. Stefan
name: Stürmer, Martin
name: Jansen, Klaus
name: Buder, Susanne
name: Nick, Sigrid
name: Hagedorn, Hans-Jochen
name: Bremer, Viviane
name: Brockmeyer, Norbert H.
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2016
Subjects: subject: Schnelltest
subject: Point-of-care
subject: sexuell übertragbare Infektion
subject: Lateral Flow Assay
subject: Nukleinsäure-Amplifikationstest
subject: 610 Medizin

description: Am 5.2.16 fand am Robert-Koch-Institut in Berlin ein Expertentreffen zum Thema „Schnelltests in der Diagnostik sexuell übertragbarer Infektionen“ statt. Das Ziel dieser Tagung war, die in einem vorangegangenen Treffen im Januar 2012 erarbeitete Bewertung der Schnelltests für den Einsatz in der Infektionsdiagnostik von HIV, HBV, HCV, T. pallidum, C. trachomatis und N. gonorrhoeae in „niedrigschwelligen Einrichtungen“ unter Berücksichtigung neuer Erkenntnisse und Entwicklungen dem aktuellen Stand anzupassen. Die von der Bundesregierung kürzlich beschlossene Strategie zur Eindämmung von HIV, Hepatitis B und C und anderen sexuell übertragbaren Infektionen beschreibt einen Mangel an Testmöglichkeiten und verfolgt eine Steigerung der Testangebote und einen besseren Zugang. Eine wichtige Option um Testbarrieren zu senken, repräsentiert der Einsatz von Schnelltests, die als niedrigschwelliges Testangebot in Beratungsstellen angeboten werden und auch als Heimtests durchgeführt werden können. Basierend auf den in klinischen Studien evaluierten Leistungsmerkmalen sind einige HIV-, HCV- und Syphilis-Schnelltests durchaus als point-of-care Test (POCT) geeignet. Für C. trachomatis und N. gonorrhoeae erreichen nur PCR-basierte POCTs eine ausreichende diagnostische Genauigkeit. Der Einsatz von Schnelltest ist in Deutschland an bestimmte Vorgaben des IfSG und MPG gebunden. Die Abgabe von HIV-Diagnostika an Privatpersonen (zwecks Heimtestung) ist in Deutschland untersagt (§ 11, MPG). Die Feststellung und Übermittlung einer Infektionskrankheit ist einem Arzt vorbehalten und darf auch nicht als Ferndiagnose erfolgen (§ 24, IfSG). Darüber hinaus unterliegen Schnelltests, wie alle labormedizinischen Analysen einer Qualitätssicherung entsprechend den Richtlinien der Bundesärztekammer.
Additional file 3 of Unfinished nursing care in healthcare settings during the COVID-19 pandemic: a systematic review
Creators: name: Bayram, Aysun
name: Chiappinotto, Stefania
name: Palese, Alvisa
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Cancer

description: Supplementary Material 3
Additional file 4 of Unfinished nursing care in healthcare settings during the COVID-19 pandemic: a systematic review
Creators: name: Bayram, Aysun
name: Chiappinotto, Stefania
name: Palese, Alvisa
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Cancer

description: Supplementary Material 4
Recombinant IFN-γ from the bank vole Myodes glareolus: a novel tool for research on rodent reservoirs of zoonotic pathogens
Creators: name: Torelli, Francesca
name: Zander, Steffen
name: Ellerbrok, Heinz
name: Kochs, Georg
name: Ulrich, Rainer G.
name: Klotz, Christian
name: Seeber, Frank
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2018
Subjects: subject: 610 Medizin

description: Rodent species like Myodes glareolus and Microtus spp. are natural reservoirs for many zoonotic pathogens causing human diseases and are gaining increasing interest in the field of eco-immunology as candidate animal models. Despite their importance the lack of immunological reagents has hampered research in these animal species. Here we report the recombinant production and functional characterization of IFN-γ, a central mediator of host’s innate and adaptive immune responses, from the bank vole M. glareolus. Soluble dimeric recMgIFN-γ was purified in high yield from Escherichia coli. Its activity on M. glareolus and Microtus arvalis kidney cell lines was assessed by immunofluorescent detection of nuclear translocation and phosphorylation of the transcription factor STAT1. RecMgIFN-γ also induced expression of an IFN-γ-regulated innate immunity gene. Inhibition of vesicular stomatitis virus replication in vole cells upon recMgIFN-γ treatment provided further evidence of its biological activity. Finally, we established a recMgIFN-γ-responsive bank vole reporter cell line that allows the sensitive titration of the cytokine activity via a bioluminescence reporter assay. Taken together, we report valuable tools for future investigations on the immune response against zoonotic pathogens in their natural animal hosts, which might foster the development of novel animal models.
Detection of Balamuthia mandrillaris DNA by real-time PCR targeting the RNase P gene
Creators: name: Kiderlen, Albrecht
name: Radam, Elke
name: Lewin, Astrid
Publisher: name: Robert Koch-Institut; Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2008
Subjects: subject: Amebiasis/parasitology
subject: Amoeba/enzymology
subject: Amoeba/genetics
subject: Amoeba/isolation & purification
subject: Animals
subject: DNA
subject: Protozoan/genetics
subject: Ribosomal/genetics
subject: Humans
subject: Polymerase Chain Reaction/methods
subject: Protozoan Proteins/genetics
subject: Protozoan Proteins/metabolism
subject: RNA
subject: Ribosomal
subject: 18S/genetics
subject: Ribonuclease P/genetics
subject: Ribonuclease P/metabolism
subject: Sensitivity and Specificity
subject: 610 Medizin

description: Background: The free-living amoeba Balamuthia mandrillaris may cause fatal encephalitis both in immunocompromised and in – apparently – immunocompetent humans and other mammalian species. Rapid, specific, sensitive, and reliable detection requiring little pathogen-specific expertise is an absolute prerequisite for a successful therapy and a welcome tool for both experimental and epidemiological research. Results: A real-time polymerase chain reaction assay using TaqMan® probes (real-time PCR) was established specifically targeting the RNase P gene of B. mandrillaris amoebae. The assay detected at least 2 (down to 0.5) genomes of B. mandrillaris grown in axenic culture. It did not react with DNA from closely related Acanthamoeba (3 species), nor with DNA from Toxoplasma gondii, Leishmania major, Pneumocystis murina, Mycobacterium bovis (BCG), human brain, various mouse organs, or from human and murine cell lines. The assay efficiently detected B. mandrillaris DNA in spiked cell cultures, spiked murine organ homogenates, B. mandrillaris-infected mice, and CNS tissue-DNA preparations from 2 patients with proven cerebral balamuthiasis. This novel primer set was successfully combined with a published set that targets the B. mandrillaris 18S rRNA gene in a duplex real-time PCR assay to ensure maximum specificity and as a precaution against false negative results. Conclusion: A real-time PCR assay for B. mandrillaris amoebae is presented, that is highly specific, sensitive, and reliable and thus suited both for diagnosis and for research.
Engaging Communities beyond the Academy: Where Humanities Advocacy and the Publicly Engaged Humanities Meet
Creators: name: Gurwitz, Beatrice
Publisher: name: Humanities Commons
Year: 2023
Subjects: subject: Humanities
subject: FOS: Humanities
subject: Humanities--Study and teaching (Higher)
subject: Scholarly publishing

description: "Engaging Communities beyond the Academy: Where Humanities Advocacy and the Publicly Engaged Humanities Meet," by Beatrice Gurwitz, an essay from the Modern Language Association's 2022 collection Publishing and Scholarly Communication in the Humanities
Reduced Degradation of CH3NH3PbI3 Solar Cells by Graphene Encapsulation
Creators: name: Reiter, Kyle
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Chemical engineering design
Compound semiconductors
Elemental semiconductors
Energy generation, conversion and storage (excl. chemical and electrical)
Microtechnology

description: Organic-inorganic halide perovskite solar cells have increased efficiencies substantially (from 3% to > 22%), within a few years. However, these solar cells degrade very rapidly due to humidity and no longer are capable of converting photons into electrons. Methylammonium Lead Triiodide (CH3NH3PbI3 or MAPbI3) is the most common type of halide perovskite solar cell and is the crystal studied in this thesis. Graphene is an effective encapsulation method of MAPbI3 perovskite to reduce degradation, while also being advantageous because of its excellent optical and conductive properties. Using a PMMA transfer method graphene was chemical vapor depostion (CVD) grown graphene was transferred onto MAPbI3 and reduced the MAPbI3 degradation rate by over 400%. The PMMA transfer method in this study is scalable for roll-to- roll manufacturing with fewer cracks, impurites, and folds improving upon dry transfer methods. To characterize degradation a fluorescent microscope was used to capture photoluminescence data at initial creation of the samples up to 528 hours of 80% humidity exposure. Atomic force microscopy was used to characterize topographical changes during degradation. The study proves that CVD graphene is an effective encapsulation method for reducing degradation of MAPbI3 due to humidity and retained 95.3% of its initial PL intensity after 384 hours of 80% humidity exposure. Furthermore, after 216 hours of 80% humidity exposure CVD graphene encapsulated MAPbI3 retained 80.2% of its initial number of peaks, and only saw a 35.1% increase in surface height. Comparatively, pristine MAPbI3 only retained 16% of its initial number of peaks and saw a 159% increase in surface height.
CONSUMER RESPONSE TO TABLE SPACING IN A FAST-CASUAL RESTAURANT
Creators: name: Clark, Howard B., III
Publisher: name: University of Kentucky
Year: 2017
Subjects: subject: Hospitality Administration and Management

description: The purpose of this research was to evaluate consumer response based on two distances (12 and 24 inches) between tables in a fast-casual restaurant. An onsite survey was conducted to measure customers’ cognitive, emotional, and behavioral responses to questions on pleasure, privacy, stress, arousal, comfort, control, customer satisfaction, and future dining intentions based on their experience with the table spacing. Results showed that table spacing has an effect on diner’s pleasure, feelings of privacy, and sense of comfort and control. The results confirmed a strong correlation between customer satisfaction and future behavioral intentions.
Experimental Investigation of a Modular Thermoacoustic Engine
Creators: name: Jantze, Karl M
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Aerospace engineering not elsewhere classified

description: A modular thermoacoustic engine (TAE) has been designed and fabricated providing a reliable bench test to study thermoacoustic instabilities. Thermoacoustic engines belong to a class of heat engines that produce acoustic power as a result of a fluid dynamic instability. The engine was built with the capability of being converted from a standing-wave thermoacoustic engine to a traveling-wave thermoacoustic engine with relative ease. Different acoustic mediums in the form of gases comprised of Helium, Argon, or Helium-Argon mixtures were used during experimentation across a range of pressures and temperature gradients. It was found that the thermodynamic properties of the acoustic medium greatly influence the thermoacoustic response of the engine in terms of operational frequency and acoustic power output.
Public Scholarship in Practice and Philosophy
Creators: name: Glass, Erin Rose
name: Vandegrift, Micah
Publisher: name: Humanities Commons
Year: 2023

description: "Public Scholarship in Practice and Philosophy," by Micah Vandegrift and Erin Rose Glass, an essay from the Modern Language Association's 2022 collection Publishing and Scholarly Communication in the Humanities
Additional file 5 of Unfinished nursing care in healthcare settings during the COVID-19 pandemic: a systematic review
Creators: name: Bayram, Aysun
name: Chiappinotto, Stefania
name: Palese, Alvisa
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Cancer

description: Supplementary Material 5
The Hyphal-Associated Adhesin and Invasin Als3 of Candida albicans Mediates Iron Acquisition from Host Ferritin
Creators: name: Almeida, Ricardo S.
name: Brunke, Sascha
name: Albrecht, Antje
name: Thewes, Sascha
name: Laue, Michael
name: Edwards, John E.
name: Filler, Scott G.
name: Hube, Bernhard
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2008
Subjects: subject: Candida albicans/metabolism
subject: Cell Line
subject: Tumor
subject: Ferritins/metabolism
subject: Fungal Proteins/metabolism
subject: Fungal Proteins/physiology
subject: Humans
subject: Hyphae/chemistry
subject: Iron/metabolism
subject: 610 Medizin

description: Iron sequestration by host iron-binding proteins is an important mechanism of resistance to microbial infections. Inside oral epithelial cells, iron is stored within ferritin, and is therefore not usually accessible to pathogenic microbes. We observed that the ferritin concentration within oral epithelial cells was directly related to their susceptibility to damage by the human pathogenic fungus, Candida albicans. Thus, we hypothesized that host ferritin is used as an iron source by this organism. We found that C. albicans was able to grow on agar at physiological pH with ferritin as the sole source of iron, while the baker's yeast Saccharomyces cerevisiae could not. A screen of C. albicans mutants lacking components of each of the three known iron acquisition systems revealed that only the reductive pathway is involved in iron utilization from ferritin by this fungus. Additionally, C. albicans hyphae, but not yeast cells, bound ferritin, and this binding was crucial for iron acquisition from ferritin. Transcriptional profiling of wild-type and hyphal-defective C. albicans strains suggested that the C. albicans invasin-like protein Als3 is required for ferritin binding. Hyphae of an Deltaals3 null mutant had a strongly reduced ability to bind ferritin and these mutant cells grew poorly on agar plates with ferritin as the sole source of iron. Heterologous expression of Als3, but not Als1 or Als5, two closely related members of the Als protein family, allowed S. cerevisiae to bind ferritin. Immunocytochemical localization of ferritin in epithelial cells infected with C. albicans showed ferritin surrounding invading hyphae of the wild-type, but not the Deltaals3 mutant strain. This mutant was also unable to damage epithelial cells in vitro. Therefore, C. albicans can exploit iron from ferritin via morphology dependent binding through Als3, suggesting that this single protein has multiple virulence attributes.
COATING OF POLYVINYLCHLORIDE FOR REDUCED CELL/BACTERIAL ADHESION AND ANTIBACTERIAL PROPERTIES
Creators: name: Almousa, Rashed Abdulaziz R
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Biomaterials
Biomedical engineering not elsewhere classified

description: A Polyvinylchloride surface was modified by coating a biocompatible, hydrophilic and antibacterial polymer by a mild surface modification method. The surface was first activated and then functionalized, followed by coating with polymer. The surface functionality was evaluated using cell adhesion, bacterial adhesion and bacterial viability for polymers with antibacterial properties. 3T3 mouse fibroblast cells were used for cell adhesion, Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus were used for bacterial adhesion in the first study, Pseudomonas aeruginosa and Staphylococcus aureus were used for bacterial adhesion and antibacterial activity in the second study.
Chapter 2 reports how we synthesized, immobilized and evaluated a novel hydrophilic polymer with anti-fouling properties onto surface of polyvinylchloride via an effective and mild surface coating technique. The polyvinylchloride surface was first activated by azidation as well as amination, and then tethering a newly synthesized hydrophilic and biocompatible polyvinylpyrrolidone having pendent reactive succinimide functionality onto the surface. Results show that the coated hydrophilic polymer significantly reduced the 3T3 fibroblast cell adhesion as well as the adhesion of the three bacterial species.
Chapter 3 reports how we prepared, immobilized and evaluated an antibacterial and anti-fouling polymer onto polyvinylchloride surface following an efficient and simple method of surface modification. The surface coated with a terpolymer constructed with N-vinylpyrrolidone, 3,4-Dichloro-5-hydroxy-2(5H)-furanone derivative and succinimide residue was evaluated with cell adhesion, bacterial adhesion and bacterial viability. Surface adhesion was evaluated with 3T3 mouse fibroblast cells and two bacterial species. Also, antibacterial activity was evaluated by bacterial viability assay with the two bacterial species. Results showed that the polymer-modified polyvinylchloride surface exhibited significantly decreased 3T3 fibroblast cell adhesion and bacterial adhesion. Furthermore, the modified polyvinylchloride surfaces exhibited significant antibacterial functions by inhibiting bacterial growth with bactericidal activity.
Altogether, we have successfully modified the surface of polyvinylchloride using a novel efficient and mild surface coating technique. The first hydrophilic polymer-coated polyvinylchloride surface significantly reduced cell adhesion as well as adhesion of three bacterial species. The second hydrophilic and antibacterial polymer-coated polyvinylchloride surface demonstrated significant antibacterial functions by inhibiting bacterial growth and killing bacteria in addition to significantly reduced 3T3 fibroblasts and bacterial adhesions.
Richard Bradley, The passage of arms
Creators: name: Hansen, Svend
Publisher: name: Acta Praehistorica et Archaeologica
Year: 2025

description: Rezension zu: Richard Bradley, The passage of arms. Archaeological analysis of prehistoric hoards and votive deposits. Cambridge University Press 1990. 234 S., 41 Abb. DM 105,-
description: Acta Praehistorica et Archaeologica, Bd. 24 1992
Additional file 6 of Unfinished nursing care in healthcare settings during the COVID-19 pandemic: a systematic review
Creators: name: Bayram, Aysun
name: Chiappinotto, Stefania
name: Palese, Alvisa
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Cancer

description: Supplementary Material 6
Additional file 7 of Unfinished nursing care in healthcare settings during the COVID-19 pandemic: a systematic review
Creators: name: Bayram, Aysun
name: Chiappinotto, Stefania
name: Palese, Alvisa
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Cancer

description: Supplementary Material 7
title: UMID 02/2024
Creators: name: (:Unkn) Unknown
Publisher: name: Umweltbundesamt
Year: 2024
Subjects: subject: UMID
subject: Gesundheit

description: Weltweit regelt das Minamata-Übereinkommen unter anderem den Einsatz von Quecksilber in Kosmetika. Trotzdem mangelt es in vielen Ländern noch an nationalen Regelungen oder Umsetzungs- und Überprüfungsmöglichkeiten, um den Einsatz der hochgiftigen Chemikalie zu kontrollieren. Am Beispiel hautaufhellender Cremes wird deutlich, dass Grenzwerte für die Quecksilberverbindungen oft tausendfach überschritten werden und so eine Gefährdung von Menschen und Umwelt besteht. Im Titelbeitrag der UMID-Ausgabe 02/2024 werden die internationalen Herausforderungen in der Quecksilberregulierung und mögliche Lösungsansätze diskutiert.Weitere Beiträge thematisieren den bisherigen Stand der Forschung zum Abwassermonitoring und neue Potenziale über bisherige Anwendungen hinaus, Arbeits- und Forschungsschwerpunkte zum Thema Allergien am BfR, mögliche Aussagen über Zusammenhänge zwischen Umwelteinflüssen und gesundheitlichen Parametern im Rahmen der Deutschen Umweltstudie zur Gesundheit (GerES), die Entwicklung und Anwendung eines neuen Fragebogens für GerES VI zu den Themen Wetter und Klima und den Nutzen des Sachstandsberichts Klimawandel und Gesundheit für einen Austausch mit dem öffentlichen Gesundheitsdienst (ÖGD) und anderen Entscheidungstragenden.Die Zeitschrift UMID: Umwelt und Mensch – Informationsdienst erscheint zweimal im Jahr und informiert über aktuelle Themen aus Umwelt und Gesundheit, Umweltmedizin und Verbraucherschutz. Die ausschließlich online erscheinende Zeitschrift UMID kann kostenfrei abonniert werden.
What to Expect from Evaluation and How to Respond to Peer Review
Creators: name: Bahri, Deepika
Publisher: name: Humanities Commons
Year: 2023

description: "What to Expect from Evaluation and How to Respond to Peer Review," by Deepika Bahri, an essay from the Modern Language Association's 2022 collection Publishing and Scholarly Communication in the Humanities
CCR5Delta32 genotypes in a German HIV-1 seroconverter cohort and report of HIV-1 infection in a CCR5Delta32 homozygous individual
Creators: name: Oh, Djin-Ye
name: Jessen, Heiko
name: Kücherer, Claudia
name: Neumann, Konrad
name: Oh, Nari
name: Poggensee, Gabriele
name: Bartmeyer, Barbara
name: Jessen, Arne
name: Pruss, Axel
name: Schumann, Ralf R.
name: Hamouda, Osamah
Publisher: name: Robert Koch-Institut; Robert Koch-Institut, Infektionsepidemiologie
Year: 2008
Subjects: subject: Humans
subject: Adult
subject: Germany
subject: Female
subject: Male
subject: Mutation
subject: Cohort Studies
subject: Disease Progression
subject: Genotype
subject: HIV Infections/blood
subject: HIV Infections/genetics
subject: HIV Seropositivity/genetics
subject: HIV-1/metabolism
subject: Heterozygote
subject: Homozygote
subject: Receptors
subject: CCR5/genetics
subject: CCR5/physiology
subject: 610 Medizin

description: Background: Homozygosity (Δ32/Δ32) for the 32 bp deletion in the chemokine receptor 5 (CCR5) gene is associated with strong resistance against HIV infection. Heterozygosity is associated with protection of HIV-1 disease progression. Methodology/Principal Findings: We genotyped a population of 737 HIV-positive adults and 463 healthy controls for the CCR5Δ32 deletion and found heterozygous frequencies of 16.2% (HIV-negative) and 17.5% (HIV-positive) among Caucasian individuals. Analysis of CCR5Δ32 influence on disease progression showed notably lower viral setpoints and a longer time to a CD4 count of
A Data Requisition Treatment Instrument For Clinical Quantifiable Soft Tissue Manipulation
Creators: name: Bhattacharjee, Abhinaba
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Digital processor architectures
Other information and computing sciences not elsewhere classified
Biomedical instrumentation
Biomechanical engineering
Circuits and systems
Control engineering, mechatronics and robotics not elsewhere classified
Engineering instrumentation
Medical devices

description: Soft tissue manipulation is a widely used practice by manual therapists from a variety of healthcare disciplines to evaluate and treat neuromusculoskeletal impairments using mechanical stimulation either by hand massage or specially-designed tools. The practice of a specific approach of targeted pressure application using distinguished rigid mechanical tools to breakdown adhesions, scar tissues and improve range of motion for affected joints is called Instrument-Assisted Soft Tissue Manipulation (IASTM). The efficacy of IASTM has been demonstrated as a means to improve mobility of joints, reduce pain, enhance flexibility and restore function. However, unlike the techniques of ultrasound, traction, electrical stimulation, etc. the practice of IASTM doesn't involve any standard to objectively characterize massage with physical parameters. Thus, most IASTM treatments are subjective to practitioner or patient subjective feedback, which essentially addresses a need to quantify therapeutic massage or IASTM treatment with adequate treatment parameters to document, better analyze, compare and validate STM treatment as an established, state-of-the-art practice.
This thesis focuses on the development and implementation of Quantifiable Soft Tissue Manipulation (QSTM™) Technology by designing an ergonomic, portable and miniaturized wired localized pressure applicator medical device (Q1), for characterizing soft tissue manipulation. Dose-load response in terms of forces in Newtons; pitch angle of the device with respect to treatment plane; stroke frequency of massage measured within stipulated time of treatment; all in real-time has been captured to characterize a QSTM session. A QSTM PC software (Q-WARE©) featuring a Treatment Record System subjective to individual patients to save and retrieve treatment diagnostics and a real-time graphical visual monitoring system has been developed from scratch on WINDOWS platform to successfully implement the technology. This quantitative analysis of STM treatment without visual monitoring has demonstrated inter-reliability and intra-reliability inconsistencies by clinicians in STM force application. While improved consistency of treatment application has been found when using visual monitoring from the QSTM feedback system. This system has also discriminated variabilities in application of high, medium and low dose-loads and stroke frequency analysis during targeted treatment sessions.
Additional file 8 of Unfinished nursing care in healthcare settings during the COVID-19 pandemic: a systematic review
Creators: name: Bayram, Aysun
name: Chiappinotto, Stefania
name: Palese, Alvisa
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Cancer

description: Supplementary Material 8
Hospital burden of pneumococcal disease in Spain (2016–2022): A retrospective study
Creators: name: Gil-Prieto, Ruth
name: Hernandez-Barrera, Valentín
name: Marín-García, Patricia
name: González-Escalada, Alba
name: Gil-de-Miguel, Ángel
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Neuroscience
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Pneumococcal disease is a leading cause of morbidity and mortality worldwide. From 2016 to 2022, 358,603 hospitalized patients were identified as having pneumococcal disease. The overall annual hospitalization rate was 108.9 hospitalizations per 100,000 people, which significantly increased with age, reaching 748.0 hospitalizations per 100,000 among those aged ≥90 years. The hospitalization rates for pneumococcal pneumonia, meningitis, and sepsis were 25.4, 0.7, and 3.5 hospitalizations per 100,000 people, respectively, reaching the highest rates in those ≥90 years of age for pneumococcal pneumonia and sepsis, with 241.6 and 22.0 hospitalizations per 100,000 people, respectively, and in those <1 year of age for meningitis, with 3.4 hospitalizations per 100,000 people. The total number of deaths among all hospitalized pneumococcal infection patients was 51,668, with a total case fatality rate of 14.4%. The case fatality rates for pneumococcal pneumonia, meningitis, and sepsis were 7.9%, 10.6%, and 19.8%, respectively. The case fatality rate increased dramatically with age. Most patients presented with at least one underlying condition. The case fatality rate among patients with at least one comorbidity was significantly higher (p < .05) than that among patients without underlying conditions (16.0% vs. 3.2%, respectively), with a fivefold greater probability of death (OR = 5.7). During this period, the annual cost of hospitalizations for the health system exceeded EUR 383 million. Thus, the use of new broad-spectrum PCVs and improved vaccination protocols for elderly individuals and people with comorbidities could help reduce the high hospital burden of disease and mortality due to pneumococcal infection in our country.
Administration of non-national immunization program vaccines for children under six in a rural county, Henan Province: Did costs matter?
Creators: name: Yin, Miaomiao
name: Cao, Yuan
name: Xu, Xiaolin
name: Peng, Hanzhi
name: Wang, Yu
name: Long, Qian
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: This study aimed to investigate caregivers’ administration of non-National Immunization Program (NIP) vaccines in rural China, and examine health system, individual, and social determinants. A cross-sectional survey (n = 1051) was conducted from July to October in 2022 in a rural county of Henan Province. Caregivers of children under six who came to township health centers for child vaccination were interviewed. Cross-tabulation and multivariate logistic regressions were used to examine the administration rate and associated factors. Qualitative interviews were conducted with healthcare professionals (n = 4) and caregivers (Focus Group Discussions, n = 4) to understand local policies, routine practices, and caregivers’ experience with the administration of non-NIP vaccines. A framework approach was used to analyze qualitative data. Quantitative and qualitative data were integrated during the interpretation of the results. The administration rate for non-NIP vaccines remained low in rural Henan, 26.7% of children had not received any non-NIP vaccines, 43.5% had received 1–2 types, and around 30% had received 3–5 types. There were no significant differences in the administration of non-NIP vaccines between left-behind and non-left-behind children after adjusting for characteristics of children, caregivers, and households. Qualitative findings reflected that the high cost of non-NIP vaccines was a primary factor influencing caregivers’ vaccination decision. Poor communication between physicians and caregivers was another significant factor, which was caused by low retention of healthcare workers, a shortage of professionals, and insufficient financial incentives for physicians. This study enriches the evidence on non-NIP vaccination among rural children, particularly for the vulnerable group of left-behind children.
Molecular Point-of-Care diagnostic for Treponema pallidum subsp. pertenue (yaws)
Creators: name: Basing, Laud Anthony
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Biomechanical engineering

description: The eradication of yaws a neglected tropical disease caused by Treponema pallidum subsp. pertenue, which affects children living in very deprived hard to reach rural communities is constrained by the lack of rapid, accurate diagnosis. I sought to develop a molecular point-of-care test for the diagnosis of yaws. A Loop-mediated isothermal amplification (LAMP) assay with primers targeting the conserved gene, tp0967, with visual detection by lateral flow test strip was developed and optimized. The limit of detection was evaluated while 63 samples from clinical cases of yaws and 5 samples with PCR-confirmed syphilis were used to determine the sensitivity and specificity of the assay compared to the current molecular testing protocol. Reagents were dried in tubes and tested up to 14 days. The developed LAMP assay was found to be optimal when run at 65oC in a water bath for 30 minutes. The limit of detection was 2.7*104 DNA copies/ml. The sensitivity of the LAMP assay using unextracted and DNA extracted samples were 0.67 and 1.00 respectively. None of the syphilis samples tested positive in any of the assays. We show the development of a fast and sensitive LAMP assay for yaws detected by lateral flow test strip. Using extracted DNA, the assay sensitivity is at par with gold standard detection. The assay can be adapted to minimal sample processing required for in-field detection without DNA extraction.
Triboelectricity and Piezoelectricity Based 3D Printed Bio-skin Sensor for Capturing Subtle Human Movements
Creators: name: Lv, Mo
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Nanotechnology not elsewhere classified

description: This thesis present the fabrication of 2 types of soft wearable electrical devices, utilizing the 3D printing technique. The devices are capable to detect human heart pulse waves and sound waves for health evaluation and speech recognition.
Additional file 1 of Ischemic heart disease-related mortality in Brazil, 2006 to 2020. A study of multiple causes of death
Creators: name: Bastos, Luiz A. V. M.
name: Villela, Paolo B.
name: Bichara, Jose L. P.
name: do Nascimento, Emilia M.
name: Bastos, Eduardo L. V. M.
name: de B Pereira, Basilio
name: Oliveira, Glaucia M. M.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Supplementary Material 1.
Additional file 2 of Ischemic heart disease-related mortality in Brazil, 2006 to 2020. A study of multiple causes of death
Creators: name: Bastos, Luiz A. V. M.
name: Villela, Paolo B.
name: Bichara, Jose L. P.
name: do Nascimento, Emilia M.
name: Bastos, Eduardo L. V. M.
name: de B Pereira, Basilio
name: Oliveira, Glaucia M. M.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Supplementary Material 2.
Urinary Volatile Organic Compounds for Detection of Breast Cancer and Monitoring Chemical and Mechanical Cancer Treatments in Mice
Creators: name: TELI, MEGHANA SHARAD
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Biomedical engineering not elsewhere classified

description: The aim of this study is to identify metabolic transformations in breast cancer through urinary volatile organic compounds in mammary pad or bone tumor mice models. Subsequently, it focuses on investigating the efficacy of therapeutic intervention through identified potential biomarkers. Methods for monitoring tumor development and treatment responses have technologically advanced over the years leading to significant increase in percent survival rates. Although these modalities are reliable, it would be beneficial to observe disease progression from a new perspective to gain greater understanding of cancer pathogenesis. Analysis of cellular energetics affected by cancer using bio-fluids can non-invasively help in prognosis and selection of treatment regimens. The hypothesis is altered profiles of urinary volatile metabolites is directly related to disrupted metabolic pathways. Additionally, effectiveness of treatments can be indicated through changes in concentration of metabolites. In this ancillary experiment, mouse urine specimens were analyzed using gas chromatography-mass spectrometry, an analytical chemistry tool in identifying volatile organic compounds. Female BALB/c mice were injected with 4T1.2 murine breast tumor cells in the mammary fat pad. Consecutively, 4T1.2 cells were injected in the right iliac artery of BALB/c mice and E0771 tumor cells injected in the tibia of C57BL/6 mice to model bone tumor. The effect of two different modes of treatment: chemical drug and mechanical stimulation was investigated through changes in compound profiles. Chemical drug therapy was conducted with dopamine agents, Triuoperazine, Fluphenazine and a statin, Pitavastatin. Mechanical stimulation included tibia and knee loading at the site of tumor cell injection were given to mice. A biological treatment mode included administration of A5 osteocyte cell line. A set of potential volatile organic compounds biomarkers differentiating mammary pad or bone confined tumors from healthy controls was identified using forward feature selection. Effect of treatments was demonstrated through hierarchical heat maps and multivariate data analysis. Compounds identified in series of experiments belonged to the class of terpenoids, precursors of cholesterol molecules. Terpene synthesis is a descending step of mevalonate pathway suggesting its potential role in cancer pathogenesis. This thesis demonstrates the ability of urine volatilomics to indicate signaling pathways inflicted in tumors. It proposes a concept of using urine to detect tumor developments at two distinct locations as well as to monitor treatment efficacy.
Microglia-astrocyte crosstalk in the amyloid plaque niche of an Alzheimer's disease mouse model, as revealed by spatial transcriptomics.
Creators: name: Mallach, Anna
name: Zielonka, Magdalena
name: van Lieshout, Veerle
name: An, Yanru
name: Khoo, Jia Hui
name: Vanheusden, Marisa
name: Chen, Wei-Ting
name: Moechars, Daan
name: Arancibia-Carcamo, I Lorena
name: Fiers, Mark
name: De Strooper, Bart
Publisher: name: The Francis Crick Institute
Year: 2024
Subjects: classificationCode: Neurosciences
subject: Neurosciences
subject: FOS: Clinical medicine
classificationCode: Cell Biology
subject: Cell Biology
classificationCode: Gene Expression
subject: Gene Expression

description: The amyloid plaque niche is a pivotal hallmark of Alzheimer's disease (AD). Here, we employ two high-resolution spatial transcriptomics (ST) platforms, CosMx and Spatial Enhanced Resolution Omics-sequencing (Stereo-seq), to characterize the transcriptomic alterations, cellular compositions, and signaling perturbations in the amyloid plaque niche in an AD mouse model. We discover heterogeneity in the cellular composition of plaque niches, marked by an increase in microglial accumulation. We profile the transcriptomic alterations of glial cells in the vicinity of plaques and conclude that the microglial response to plaques is consistent across different brain regions, while the astrocytic response is more heterogeneous. Meanwhile, as the microglial density of plaque niches increases, astrocytes acquire a more neurotoxic phenotype and play a key role in inducing GABAergic signaling and decreasing glutamatergic signaling in hippocampal neurons. We thus show that the accumulation of microglia around hippocampal plaques disrupts astrocytic signaling, in turn inducing an imbalance in neuronal synaptic signaling.
On the development of an open-source preprocessing framework for finite element simulations
Creators: name: Mallory, Alexandra D
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Aerospace structures
Aerospace materials
Aerospace engineering not elsewhere classified
CAD/CAM systems
Civil engineering not elsewhere classified
Mechanical engineering not elsewhere classified
Materials engineering not elsewhere classified

description: Computational modeling is essential for material and structural analyses for a multitude of reasons, including for the improvement of design and reducing manufacturing costs. However, the cost of commercial finite element packages prevent companies with limited financial resources from accessing them. Free finite element solvers, such as Warp3D, exist as robust alternatives to commercial finite element analysis (FEA) packages. This and other open-source finite element solvers are not necessarily easy to use. This is mainly due to a lack of a preprocessing framework, where users can generate meshes, apply boundary conditions and forces, or define materials. We developed a preprocessor for Warp3d, which is referred to as W3DInput, to generate input files for the processor. W3DInput creates a general framework, at no cost, to go from CAD models to structural analysis. With this preprocessor, the user can import a mesh from a mesh generator software – for this project, Gmsh was utilized – and the preprocessor will step the user through the necessary inputs for a Warp3D file. By using this preprocessor, the input file is guaranteed to be in the correct order and format that is readable by the solver, and makes it more accessible for users of all levels. With this preprocessor, five use cases were created: a cantilever beam, a displacement control test, a displacement control test with a material defined by a user-defined stress-strain curve, a crystal plasticity model, and pallet. Results were outputted to Exodus II files for viewing in Paraview, and the results were verified by checking the stress-strain curves. Results from these use cases show that the input files generated from the preprocessor functions were correct.
Acceptance and attitudes towards COVID-19 vaccination during pregnancy in Canada
Creators: name: Bondy, Suraya
name: McClymont, Elisabeth
name: Av-Gay, Gal
name: Albert, Arianne
name: Andrade, Janice
name: Blitz, Sandra
name: Folkes, Ianna
name: Forward, Lucia
name: Fraser, Erin
name: Grays, Sela
name: Barrett, Jon
name: Bettinger, Julie
name: Bogler, Tali
name: Boucoiran, Isabelle
name: Castillo, Eliana
name: D’Souza, Rohan
name: El-Chaâr, Darine
name: Fadel, Shaza
name: Kuret, Verena
name: Ogilvie, Gina S.
name: Poliquin, Vanessa
name: Sadarangani, Manish
name: Scott, Heather
name: Snelgrove, John W.
name: Tunde-Byass, Modupe
name: Money, Deborah
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: The COVID-19 pandemic posed a unique set of risks to pregnant women and pregnant people. SARS-CoV-2 infection in pregnancy is associated with increased risk of severe illness and adverse perinatal outcomes. However, evidence regarding the use of COVID-19 vaccines in pregnancy shows safety and efficacy. Despite eligibility and recommendations for COVID-19 vaccination among pregnant women and pregnant people in Canada, uptake remains lower compared to the general population, warranting exploration of influencing factors. The COVERED study, a national prospective cohort, utilized web-based surveys to collect data from pregnant women and pregnant people across Canada on COVID-19 vaccine attitudes, uptake, and hesitancy factors from July 2021 to December 2023. Survey questions were informed by validated tools including the WHO Vaccine Hesitancy Scale (VHS) and the Theory of Planned Behavior (TPB). Of 1093 respondents who were pregnant at the time of the survey, 87.7% received or intended to receive a COVID-19 vaccine during pregnancy. TPB variables such as positive attitudes toward COVID-19 vaccines (OR = 1.11, 95% CI = 1.08–1.14), direct social norms, and indirect social norms were significantly associated with vaccine acceptance. Perceived vaccine risks, assessed by the WHO VHS, were greater in those not accepting of the vaccine. Our study identified several key factors that play a role in vaccine uptake: perceived vaccine risks and safety and social norms. These findings may guide public health recommendations and prenatal vaccine counseling strategies.