cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 3 of Prevalence of dyslipidaemia within Polish nurses. Cross-sectional study - single and multiple linear regression models and ROC analysis
Creators: name: Bartosiewicz, Anna
name: Wyszyńska, Justyna
name: Matłosz, Piotr
name: Łuszczki, Edyta
name: Oleksy, Łukasz
name: Stolarczyk, Artur
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Biological Sciences not elsewhere classified

description: Supplementary Material 3
การวางแผนการตลาดดิจิทัลเพื่อการส่งเสริมการตลาดสำหรับผู้ประกอบการ หนึ่งตำบลหนึ่งผลิตภัณฑ์ในอำเภอคีรีมาศ จังหวัดสุโขทัย ภายใต้การแพร่ระบาด ของเชื้อไวรัสโควิด – 19
Creators: name: รัตติกาญจน์ ภูษิต
Publisher: name: สถาบันวิจัยและพัฒนา มหาวิทยาลัยกาฬสินธุ์
Year: 2024
Subjects: โควิด-19
ผู้ประกอบการ
การตลาดดิจิทัล
หนึ่งตำบลหนึ่งผลิตภัณฑ์

description: วารสารมนุษยศาสตร์ สังคมศาสตร์ และนวัตกรรม มหาวิทยาลัยกาฬสินธุ์, 3, 2, 107-122
Les Plaques Amyloïdes Et La Dégénérescence Neurofibrillaire
Creators: name: , Amara
Publisher: name: Zenodo
Year: 2018
Subjects: plaques seniles-
maladie d'alzheimer

description: Les plaques amyloïdes, ou plaques séniles, furent les premières décrites. Il s’agit de petits dépôts denses d'une protéine, la bêta-amyloïde. Celle-ci est chimiquement

« adhésive » et s’agglutine progressivement pour former les plaques.

La bêta-amyloïde provient d’une protéine plus grosse présente dans la membrane entourant les cellules nerveuses saines
การพัฒนากิจกรรมการเรียนรู้วิทยาศาสตร์ เรื่อง วัสดุและสสาร ด้วยการจัดการเรียนรู้รูปแบบสืบเสาะหาความรู้ (5E) เพื่อส่งเสริมผลสัมฤทธิ์ทางการเรียน ของนักเรียนชั้นประถมศึกษาปีที่ 4
Creators: name: เอกลักษณ์ ราชไรกิจ
Publisher: name: สถาบันวิจัยและพัฒนา มหาวิทยาลัยกาฬสินธุ์
Year: 2024
Subjects: กิจกรรมการเรียนรู้วิทยาศาสตร์
การสืบเสาะหาความรู้ (5E)
ผลสัมฤทธิ์ทางการเรียน
ความพึงพอใจ

description: วารสารมนุษยศาสตร์ สังคมศาสตร์ และนวัตกรรม มหาวิทยาลัยกาฬสินธุ์, 3, 2, 123-134
Unknown Input Observer For Cyber-Physical Systems Subjected To Malicious Attacks
Creators: name: Zhang, Mukai
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Control engineering, mechatronics and robotics not elsewhere classified

description: Cyber-Physical Systems (CPSs) consist of physical and computational components usually interconnected through the internet. This type of systems have found applications in robotic surgery, smart medical services, driverless cars, smart power grids as well as in modern homes and offices. For a CPS to function properly, a reliable and secure communications between the system physical and cyber elements is of utmost importance. Malicious attacks during control signals and output measurements transmission between the physical plant and the control center must be addressed, which is the main research problem studied in this thesis.
A novel robust observer was proposed to synthesize a combined controller-observer compensator for a class of CPSs with sparse malicious attacks and arbitrary disturbances. The compensator consists of a controller, a norm approximator, and an unknown input observer (UIO). The proposed observer was compared with a norm-based observer given in the literature to show its advantage. To further enhance the proposed observer's performance against arbitrary disturbances, design methods were given that use fictitious output measurements and error correcting code (ECC) approach. The design of the UIO was extended to a bank of UIOs in order to improve the observer's performance against sparse malicious attacks.
The proposed observer can be used in the design of UIO-based fault detection and isolation (FDI) algorithms as well as in the distributed fault-tolerant control of large-scale interconnected systems. The results of this thesis can be applied to the design of controller-observer compensators for CPSs with modeling uncertainties.
PRODUCTION OF LAMBDA_C BARYONS IN PROTON-PROTON AND LEAD-LEAD COLLISIONS AT 5.02 TEV WITH CMS
Creators: name: Xiao, Rui
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Nuclear physics

description: Due to the large masses, heavy quarks are produced early and experience the full evolution of the medium. The comparison between the nuclear modification factors of heavy flavor and light hadrons can provide insights into the expected flavor dependence of parton energy loss. The relative coalescence contribution to baryon production is expected to be more significant than that to mesons because of their larger number of constituent quarks. In particular, models involving coalescence of charm and light-flavor quarks predict a large enhancement in the Λ+c /D0 production ratio in the heavy ion collisions relative to pp collisions and also predict that this enhancement has a strong pT dependence. This dissertation presents the production of inclusive (prompt) Λ+c baryons in proton- proton and lead-lead collisions at 5.02 TeV in 2015 (2017 and 2018) with CMS detector at the CERN LHC. These two analyses show that Λ+c baryons production is found to be suppressed in heavy ion collisions. This suppression is consistent with the suppression observed in D0 meson measurements. The Λ+c /D0 production ratios in pp collisions are consistent with a model obtained by adding color reconnection in hadronization to PYTHIA8. Also the Λ+c /D0 production ratios in pp collisions are consistent with the model that includes enhanced contribution from the decay of excited charm baryons and the model includes the effect of fragmentation and coalescence. There is a hint of an enhancement in the Λ+c /D0 production ratio in PbPb collisions in the pT range of 6–12.5 GeV/c compared to pp collisions. The Λ+c /D0 ratios in pp and PbPb collisions for pT > 12.5 GeV/c are found to be consistent with each other.
COMPUTATIONAL DESIGN AND EXPERIMENTAL VALIDATION OF DIAMOND-BASED QUANTUM EMITTERS
Creators: name: Akomolede, Oluseye
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Electrical engineering not elsewhere classified
Quantum optics and quantum optomechanics

description: The enhancement of the emission from nitrogen vacancy color centers will help facilitate advancements in quantum information technology. To this end, the reduction of the excited state lifetimes of NVs as well as the design of devices which support electroluminescence of nitrogen vacancies, as well as the broadband enhancement of the emission from these centers is of great importance. In this study, we create diamond thin films containing nitrogen vacancy color centers using salt-assisted ultrasonic disaggregation techniques and electrophoretic deposition. These films are implanted with xenon atoms and the resulting structures are characterized optically. We report a reduction in the bulk emission lifetime of nitrogen vacancy color centers of two orders of magnitude. A coupled-mode theory approach is used to analyze the emission from the xenon-doped nanodiamond species. It is determined that the lifetime reduction occurs due to coupling between nitrogen vacancy color centers and xenon color centers within the diamond lattice. A diamond field effect transistor is investigated via simulations utilizing Sentaurus TCAD software. The device is scaled by three orders of magnitude from previous experiments involving the same structure. Transport characteristics are obtained from simulation results. We confirm the existence of a decreasing saturation voltage with a decrease in gate length in the diamond field effect transistor. Further investigation into the device’s viability as a quantum emitter is conducted. The design of a single photon source utilizing plasmonic structures to enhance emission from nitrogen vacancy color centers is proposed. The plasmonic structure is investigated to extract operating parameters and to quantify the optical coupling and propagation characteristics for various physical dimensions The design of a plasmonic device which features both electroluminescence via nitrogen vacancy color centers and their enhancement via plasmonic effects is numerically simulated. The device features large Purcell enhancement factor and good photon emission rate. In summary, this work paves the way towards the advancement of the nitrogen vacancy color center as a stable source of room temperature photons for quantum information applications.
Interventi di psicologia clinica attraverso le nuove tecnologie: la continuit� terapeutica per pazienti obesi
Creators: name: CUZZIOL, Paola
Publisher: name: Universit� degli studi di Bergamo
Year: 2011

description: Conclusion: Internet-based weight loss and weight maintenance program appears to be a viable medium for promoting long-term weight loss integrating traditional in-hospital treatments, in favor of a change towards a new ?health care everywhere? approach.
MOLECULAR NETWORK CONTROLLING THE OVULE DEVELOPMENT IN ARABIDOPSIS THALIANA
Creators: name: SINHA ROY, DOLA
Publisher: name: Universit� degli Studi di Milano
Year: 2010

description: Ovules are the essential organ for plant reproduction. Megasporogenesis, megagametogenesis, fertilization and embryogenesis take place within the ovule. In the ovule both sporophytic and gametophytic generation coexist. The analyses of this developmental process provides an excellent tool to understand the molecular mechanism involved in controlling the basic processes like primordia initiation, specification, cell division, expansion and differentiation. This system allows the study of basic developmental process as well as the evolutionary prospect in the same context. In my thesis I have used Arabidopsis thaliana as a model system.The aim of this project is to study the genetic and hormone network controlling ovule primordia formation. Reduction in number of ovule primordia was already described in the ant mutant (Baker et al., 1996). cuc1 and cuc2 single mutant display similar number of ovule primordia like wild type. Double mutant cuc1cuc2 shows defect in shoot apical meristem formation, two cotyledons fused along their margin to form a cup shaped structure (Aida et al., 1997). Normally it is difficult to get the double mutant plants from the fused cotyledon. Adventitious shoots regenerated from mutant calli form the double mutant flowers, which also display the reduction of number of ovule primordia (Ishida et al., 2000). The goal of this work was to investigate the interaction among ANT, CUC1, CUC2 genes to determine ovule primordia formation.
Characterization of the Quiet Flow Freestream and a Flat Plate Model in the Boeing/AFOSR Mach 6 Quiet Tunnel
Creators: name: Mamrol, Derek V
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Aerospace engineering not elsewhere classified

description: The ambient pressure fluctuations within a wind tunnel test environment can severely affect the boundary layer transition observed on test articles. The Boeing/AFOSR Mach 6 Quiet Tunnel was designed to minimize these fluctuations, also referred to as noise, and is the world's premier facility for studying hypersonic boundary layer transition in a quiet flow environment. All experiments performed for this work were conducted at this facility. The freestream flow field of this tunnel has been characterized multiple times since its creation, but an extensive three-dimensional spatial sweep has never been conducted. A pitot rake model was designed and manufactured in order to perform an extensive spatial survey of tunnel noise. This model created measurement capabilities that were previously unknown to the BAM6QT facility, including the ability to take multiple concurrent freestream pitot probe measurements. The performance of this new measurement instrument was evaluated and suggestions for future verification tests are made. This new measurement apparatus was used to investigate the effect that cavities in the tunnel wall had on the freestream noise level. These cavities are created by the installation of optical access windows in the tunnel nozzle wall. The experiments conducted provide evidence that the tunnel wall cavities do increase the noise downstream of their location by approximately 100%, however a control dataset is needed to verify this finding. In addition to tunnel characterization, a novel flat plate model was evaluated for use in the BAM6QT. This model was intended for use as a platform for observing second-mode instability growth. These experiments show that the initial flat plate geometry used was incompatible with the BAM6QT, as the tunnel could not achieve nominal flow conditions with the model installed. The flat plate model was streamlined to rectify the startup issues experienced, but no evidence of the second-mode instability was found. A 3° half-angle cone is being designed to replace the flat plate model as a platform for the continuation of this project.
Additional file 6 of The development of a novel zeolite-based assay for efficient and deep plasma proteomic profiling
Creators: name: Li, Nan
name: Huang, Jingnan
name: He, Shangwen
name: Zheng, Qiaocong
name: Ye, Feng
name: Qin, Zhengxing
name: Wang, Dong
name: Xiao, Ting
name: Mao, Mengyuan
name: Zhou, Zhenhua
name: Tang, Tingxi
name: Zhang, Longshan
name: Wang, Xiaoqing
name: Wang, Yingqiao
name: Lyu, Ying
name: Liu, Laiyu
name: Dai, Lingyun
name: Wang, Jigang
name: Guan, Jian
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file6: Table S1. Physical characteristics of materials. Table S2. Workflow of different materials assay. Table S3. Performance measures for M086-based and other plasma proteomic methods. Table S4. Baseline of HCC Cohort. Table S5. Clinical information of HCC Cohort.
MODULAZIONE DEL SIGNALING DI STAT PER PREVENIRE IL RIGETTO DEL TRAPIANTO DI MIDOLLO OSSEO ALLOGENICO
Creators: name: MARIOTTI, JACOPO
Publisher: name: Universit� degli Studi di Milano
Year: 2013

description: Janus Kinase (JAK)/ Signal Transducer of Activated Transcription (STAT) signaling represents the main molecular pathway dictating T cell differentiation both in humans and in mice. Allogeneic hematopoietic stem cell transplantation (HSCT) is a potential curative strategy for patients with hematologic malignancies and its outcome depends on the interplay between host and donor immune system resulting in graft rejection (GR) or graft versus host disease (GVHD), respectively. We therefore proposed to investigate the role of JAK/STAT signaling in these two phenomena that are biologically considered as mirror images. First, we found that host-mediated graft rejection requires JAK3 expression and that a broad inhibitor of STAT3 signaling prevents GR in a mouse model of rejection. Second, we moved to assess the role of STAT3 signaling in acute GVHD that represents the major cause of mortality in allogeneic HSCT, for which administration of FoxP3+ Treg cells has been proposed as a therapy. However, the phenotypic stability of Treg cells is controversial and cytokines that signal through STAT3 can inhibit FoxP3 expression. In a mouse model of acute GVHD, we assessed whether the elimination of STAT3 in T cells could limit the severity of GVHD, and if so, what mechanisms were involved. We found STAT3 limited the numbers of FoxP3+ Tregs following allogeneic bone marrow transplant by two pathways: instability of natural Tregs and inhibition of inducible Treg polarization from na�ve CD4+ T cells. Third, we found that the infusion in vivo of a potent inhibitor of STAT3 could prevent the onset of acute GVHD, both by reducing Th1 alloreactivity and maintaining the Treg subset in vivo. These data strongly support the potential use of JAK/STAT inhibitors in vivo in order to prevent GR and GVHD in patients receiving allogeneic HSCT.
Demanding Rights under High Stress: Dilemmas of Leadership and Sustaining Local Participation in the U.S. Immigrant Rights Movement
Creators: name: Cox, Jenean
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Sociology not elsewhere classified
Social change

description: Immigrants have limited opportunities for political engagement in the United States without fear of police profiling and deportation. Leaders in the U.S. immigrant rights movement must find ways of encouraging participation in local immigrant rights activism efforts despite the hostile political climate against immigrants in the United States. In the U.S. immigrant rights movement, local participation in community-based immigrant rights organizations (CBIROs) is an important part of sustaining immigrant rights efforts. This dissertation examines how leaders’ interactions with members influence the likelihood that members will continue to participate in CBIROs. I draw on 29 in-depth interviews with both members and leaders in the Muslim-American Rights Alliance (MARA), a CBIRO in the Midwest. MARA’s leaders use authority signals, inclusion practices, and legitimacy tactics to address the dilemmas associated with sustaining local member participation in the U.S. immigrant rights movement. MARA’s leaders use supportive and inspirational authority signals to maintain the charismatic authority of MARA’s Executive Director. MARA’s leaders use political education and decision-making inclusion practices to counteract the consequences of oligarchy within MARA. MARA’s leaders use professional and street legitimacy tactics to establish the organization’s legitimacy within the local immigrant rights community. The findings from this dissertation allow for new insights into how leadership in CBIROs influences sustained participation in local immigrant rights activism.
New non-invasive approaches for proteomics and metabolomics analyses
Creators: name: BARBERIS, ELETTRA
Publisher: name: Universit� degli Studi del Piemonte Orientale Amedeo Avogadro
Year: 2020

description: Recent technological developments in analytical chemistry spurred the analysis of historical, archaeological and paleontological objects. The Identification of proteins and small molecules from cultural heritage objects is crucial to characterize the materials used by the artists and it can provide invaluable information for designing restoration interventions. All most the developed analytical procedures require at least a micro sampling from the object. However, non-invasive techniques are always preferred for the analysis of precious and unique objects.
A part of this PhD research focused on the development and application of new non-invasive methods for the analysis of cultural heritage. A new method for the non-invasive analysis of proteins and small molecules with mass spectrometry from cultural heritage objects was discussed; the results obtained using a non-invasive imaging instrument on ancient Egyptian mural paintings were also presented; the development and application of non-invasive methods that use portable infrared spectroscopy instrumentation were shown. The recent revolution in mass spectrometry technology with the introduction of high throughput instruments and techniques has led to the widespread expansion of advanced analytical methods in health science. But today, the main target of modern mass spectrometry analysis in biomedical research can be summarize as the development of effective and reliable approaches able of discriminating diseased conditions at their earliest stage, in a non or minimally-invasive manner.
The aim of the second part of this PhD research was the development and application of non-invasive methods for the analysis of biological materials. A new method for the non-invasive analysis and characterization of adenoma in colon rectal cancer was presented and a combined bi and mono-dimensional gas chromatography mass spectrometry approach for the identification of new biomarkers for prostate cancer in serum was discussed.
Hierarchical Hypergraphs for Knowledge-centric Robot Systems: a Composable Structural Meta Model and its Domain Specific Language NPC4
Creators: name: Scioni, Enea
name: Huebel, Nico
name: Blumenthal, Sebastian
name: Shakhimardanov, Azamat
name: Klotzbuecher, Markus
name: Garcia, Hugo
name: Bruyninckx, Herman
Publisher: name: Universit� degli studi di Bergamo
Year: 2016

description: Many robotics applications rely on graph models in one form or another: perception via probabilistic graphical models such as Bayesian Networks or Factor Graphs; control diagrams and other computational ``function block'' models; software component architectures; Finite State Machines; kinematics and dynamics of actuated mechanical structures; world models and maps; knowledge relationships as ``RDF triples''; etc.In traditional graphs, each edge connects just two nodes, and graphs are ``flat'', that is, a node does not contain other nodes.
This paper advocates the research hypothesis that hierarchical hypergraphs are a better structural meta model: (i) an edge can connect more than two nodes, (ii) the attachment between nodes and edges is made explicit in the form of ``ports'' to provide a uniquely identifiable view on a node's internal behaviour, and (iii) every node can in itself be another hierarchical hypergraph.These properties are encoded formally in a Domain Specific Language (or ``meta meta model''), called ``NPC4'', built with node, port, connector, and container as primitives, and contains and connects as relationships. The formal model of NPC4 is designed to maximally support its composability as a meta modelling language, for both the structural and behavioural parts of more concrete DSLs that can be built on top of it, each in a specific domain context.
NPC4 introduces a particular primitive, the container, to support overlapping contexts. It targets the following major targets in knowledge-centric robotics systems: (i) various levels of abstraction in domain models, (ii) ``multiple inheritance'' from (or rather ``conformance to'') different knowledge domains, and (iii) connecting one or more domain DSLs to the same software infrastructure in which they all have to be ``activated''.
Additional file 2 of Exploring strategies to growth wild turnip sprouts as healthy food
Creators: name: López-Belchí, M. D.
name: Toro, M. T.
name: Illanes, M.
name: Henríquez-Aedo, K.
name: Fernández-Martinez, J.
name: Schoebitz, M.
name: Zapata, N.
name: Fischer, S.
name: Pinto, A.
name: García-Viguera, C.
name: Moreno, D. A.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Mental Health
subject: Plant Biology

description: Additional file 2: Table S1. ANOVA results of Length sprouts for wild turnip. Table S2. ANOVA results of Fresh Weight sprouts for wild turnip. Table S3. ANOVA results of Dry Weight sprouts for wild turnip. Table S4. ANOVA results of Total Glucosinolates for wild turnip. Table S5. ANOVA results of Total Anthocyanins for wild turnip. Table S6. ANOVA results of Length sprouts for broccoli. Table S7. ANOVA results of Fresh Weight sprouts for broccoli. Table S8. ANOVA results of Dry Weight sprouts for broccoli. Table S9. ANOVA results of Total Glucosinolates for broccoli. Table S10. ANOVA results of Total Anthocyanins for broccoli.
MODELS OF TURBULENCE. APPLICATIONS TO PARTICULATE MIXING INDUCED BY TRAFFIC FLOW IN URBAN AREAS.
Creators: name: AGOSTI, ABRAMO
Publisher: name: Universit� degli Studi di Milano
Year: 2013

description: In this work we address our attention to the estimation of the contribution of non-exhaust sources, like brake abrasion, tire and road wear and resuspension of particles, to the final PM air concentration; particularly we focus our investigation on the resuspension of PM deposited on road pavement surfaces and raised by the air turbulence produced by the vehicles flux, under urban and extra-urban traffic conditions.
Our approach to the problem is based on modeling techniques. We refer to measurement data from literature to determine the selected empirical parameters contained in our models.
Analytical models based on algebraic eddy diffusivity hypothesis are applied to describe the mean statistical component of flow generated by air recirculation inside a canyon and by the far-wake structure besides moving vehicles of simplified geometrical shapes.
The analysis of the far wake solutions is suitable to the description of vehicle wakes interaction, which permits to apply our analysis to different driving cycles conditions.
Numerical simulations based on finite element discretization of suitable two-equation turbulence models are employed to describe near-wake structures, which cause the strongest mixing of atmospheric pollutants and resuspension of road dust.
These different components of turbulence fields at different scales of the street geometry are composed to define a set of operational and numerical models for the dispersion dynamics at the canyon scale of two classes of PM10 pollutants, corresponding to a Soot and a road dust components.
The deposition and the resuspension of pollutants are described by resistance and filtration models on porous asphalts, inserting the corresponding terms in the dispersion equations as
suitable boundary conditions on the ground.
We estimate the resuspension fraction of traffic-related PM10 emissions at the tailpipe, through a simplified linear-emission model, considering representative data describing traffic statistics coming from empirical data.
Profile laws of resuspension factors are drawn, for different vehicles geometries and velocities, and how resuspension changes with different asphalt characteristics.
The results are applied to typical traffic situations in the city of Milan, studying the effect of implementations of different reduction scenarios to the total amount of traffic-related PM10 emissions.
The results point at a new approach to the local PM10 reduction policies, based on more effective asphalt design and maintenance.
Finally, we apply one of the dispersion operational models to the case of a congested urban traffic configuration in a canyon street, in order to obtain the pollutant spatial distribution.
STUDIO DEGLI ADDOTTI CATECOLAMMINE-PROTEINE IN SOSTANZA NERA E NEL PUTAMEN UMANI
Creators: name: TEMPESTINI, ALESSIA
Publisher: name: Universit� degli Studi di Milano
Year: 2010

description: Parkinson?s disease is a neurodegenerative disorder that results primarily from the degeneration of dopaminergic neurons in the substantia nigra and locus coeruleus. Neurons of both areas contain a melanic pigment called neuromelanin. This pigment accumulates linearly during aging and originates from an excess of free cytosolic dopamine. Dopamine, like other catecholamines, can easily oxidize to its corresponding quinone when free in the cytosol. Dopamine-quinone is very reactive and can either polymerize to form the neuromelanin core, or react with nucleophilic species like free cysteine, glutathione, or cysteine residues of proteins. Since cysteine residues are often localized in the active site of the enzyme, the adduct between dopamine-quinone and cysteine may alter the protein function and thus become a potential neurotoxic factor for the cellular life. In order to verify if dopamine-protein adducts are present in human cerebral tissue, the protein fractions from human substantia nigra and putamen were extracted and analysed. The extracted proteins were incubated with a amino-phenyl boronate resin that selectively binds the cis-diol group of dopamine, a reaction that is reversible at acidic pH. By using this system, dopaminated proteins can be isolated from the protein fraction. The elutes from the resin were hydrolysed and analysed by HPLC for the presence of cysteine-dopamine adducts. For both brain areas 3 different subjects of ages ranging from 52 to 89 years old were analyzed. In neither brain area the presence of cysteinyl-dopamine has been observed. Possible explanations for these results are: 1) excess of dopamine in human brain tissue is stored in neuromelanin and is therefore not able to react with proteins; 2) dopamine reacts with proteins but the adducts are either removed by the ubiquitin-proteasome system or included in the neuromelanin structure, thereby forming the peptidic component of the pigment.
sj-pdf-1-vmj-10.1177_1358863X211034577 – Supplemental material for Intensity-dependent effects of exercise therapy on walking performance and aerobic fitness in symptomatic patients with lower-extremity peripheral artery disease: A systematic review and meta-analysis
Creators: name: Fassora, Mattia
name: Calanca, Luca
name: Jaques, Cécile
name: Mazzolai, Lucia
name: Kayser, Bengt
name: Lanzi, Stefano
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Cardiology
subject: 110323 Surgery
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-1-vmj-10.1177_1358863X211034577 for Intensity-dependent effects of exercise therapy on walking performance and aerobic fitness in symptomatic patients with lower-extremity peripheral artery disease: A systematic review and meta-analysis by Mattia Fassora, Luca Calanca, Cécile Jaques, Lucia Mazzolai, Bengt Kayser and Stefano Lanzi in Vascular Medicine
sj-docx-1-ict-10.1177_15347354211044089 – Supplemental material for Social Support Received and Provided in the Adjustment of Parents of Children With Cancer
Creators: name: Melguizo-Garín, Anabel
name: Hombrados-Mendieta, Isabel
name: José Martos-Méndez, Mª
name: Ruiz-Rodríguez, Iván
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: 111702 Aged Health Care

description: Supplemental material, sj-docx-1-ict-10.1177_15347354211044089 for Social Support Received and Provided in the Adjustment of Parents of Children With Cancer by Anabel Melguizo-Garín, Isabel Hombrados-Mendieta, Mª José Martos-Méndez and Iván Ruiz-Rodríguez in Integrative Cancer Therapies
sj-pdf-1-tmj-10.1177_03008916211047888 – Supplemental material for Transient asymptomatic pulmonary opacities and interstitial lung disease in EGFR-mutated non-small cell lung cancer treated with osimertinib
Creators: name: Taronna, Gianluca
name: Leonetti, Alessandro
name: Gustavo Dall’Olio, Filippo
name: Rizzo, Alessandro
name: Parisi, Claudia
name: Buti, Sebastiano
name: Bordi, Paola
name: Brocchi, Stefano
name: Golfieri, Rita
name: Ardizzoni, Andrea
name: Sverzellati, Nicola
name: Tiseo, Marcello
Publisher: name: SAGE Journals
Year: 2021
Subjects: Medicine

description: Supplemental material, sj-pdf-1-tmj-10.1177_03008916211047888 for Transient asymptomatic pulmonary opacities and interstitial lung disease in EGFR-mutated non-small cell lung cancer treated with osimertinib by Gianluca Taronna, Alessandro Leonetti, Filippo Gustavo Dall’Olio, Alessandro Rizzo, Claudia Parisi, Sebastiano Buti, Paola Bordi, Stefano Brocchi, Rita Golfieri, Andrea Ardizzoni, Nicola Sverzellati and Marcello Tiseo in Tumori Journal
Additional file 1 of Effects of a 10-Week Exercise and Nutritional Intervention with Variable Dietary Carbohydrates and Glycaemic Indices on Substrate Metabolism, Glycogen Storage, and Endurance Performance in Men: A Randomized Controlled Trial
Creators: name: Moitzi, Anna Maria
name: Krššák, Martin
name: Klepochova, Radka
name: Triska, Christoph
name: Csapo, Robert
name: König, Daniel
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Additional file 1. Table 1. Nutritional guidelines for each intervention group. Table 2. Example meal plan for one day for every intervention group. Table 3. Example week of the prescribed endurance training plan.
Ultrasound Imaging of Tissue Remodeling in Murine Models of Vascular Disease and Repair
Creators: name: Berman, Alycia Gabrielle
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Biomedical engineering not elsewhere classified

description: An abdominal aortic aneurysm (AAA) is a pathological dilation of the abdominal aorta, as defined by a 50% increase in diameter or a diameter greater than 3 cm. While typically asymptomatic, there is a risk that the AAA will rupture, causing massive hemorrhaging and high mortality rates. Thus, once detected, the clinician must choose between surveillance and elective surgical repair. The first option carries the risk of rupture; the second risks complications and graft failure. Currently, clinical metrics of rupture risk are dependent on diameter and growth rate. However, a number of studies have indicated that, although rupture risk does increase with increased diameter, there are also a large number of patients with aneurysms for which the diameter criteria is insufficient. There remains a strong need to 1) determine better estimates of rupture risk in order to accurately assess the need for surgery and 2) improve surgical treatment to reduce perioperative risk.
Herein, we use ultrasound in mice to address these two prevalent uncertainties in aneurysm development and treatment. First, we further develop a murine aneurysm model that forms large aneurysms with distal thrombus. To increase the applicability of the model, we modulate aneurysm growth by altering elastase concentration and lysyl oxidase inhibition. We show that initial elastase concentration impacts aneurysm size, which is driven in part by a change in the degree of initial degradation of the aortic wall. We also demonstrate that lysyl oxidase inhibition (via BAPN) remains necessary for expansion even after the initial aneurysm formation and that removal of the lysyl oxidase inhibitor effectively stops growth in this model. As a final point, we show that female mice develop larger aneurysms than the males using this model. Then, with the aim of improving surgical treatment options, we explore the patency of various design parameters involved in tissue-engineered vascular grafts. To do so, we assess the allowable parameter design space of murine textile arterial grafts, so as to lead to better selection of key design components. Overall, the findings in this thesis demonstrate the applicability of ultrasound in small animals to improve aneurysm diagnostic and treatment options.
MODELING THE CORTICAL VISUAL PATHWAYS USING ARTIFICIAL NEURAL NETWORKS
Creators: name: Han, Zhixian
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Cognitive and computational psychology not elsewhere classified

description: Although in conventional models of visual information processing, object identity and spatial information are processed separately and independently in ventral and dorsal cortical visual pathways respectively, some recent studies have shown that information about both object’s identity (of shape) and space are present in both visual pathways. However, it is still unclear whether the presence of identity and spatial information in both pathways have functional roles or not. In a recent study (Han & Sereno, in press), we have tried to answer this question through computational modeling. Our simulation results suggested that two separate cortical visual pathways for identity and space (1) actively retain information about both identity and space; (2) retain information about identity and space differently; (3) that this differently retained information about identity and space in the two pathways may be necessary to accurately and optimally recognize and localize objects. However, in these simulations, there was only one object in each image. In reality, there may be more than one object in an image. In this master’s thesis, I have tried to run visual recognition simulations with two objects in each image. My two object simulations suggest that (1) the two separate cortical visual pathways for identity and space (orientation) still retain information about both identity and space (orientation) when there are two objects in each image; (2) the retained information about identity and space (orientation) in the two pathways may be necessary to accurately and optimally recognize objects’ identity and orientation. These results agree with our one object simulation results.
Additional file 1 of Factors influencing hospitalization or emergency department visits and mortality in type 2 diabetes following the onset of new cardiovascular diagnoses in a population-based study
Creators: name: Agvall, Björn
name: Jonasson, Junmei Miao
name: Galozy, Alexander
name: Halling, Anders
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Cancer

description: Supplementary Material 1
Loan officers and clients' over-indebtedness prevention. The case of Banco Adopem
Creators: name: SILVA AFONSO, Joana
Publisher: name: Universit� degli studi di Bergamo
Year: 2014

description: Loan officers act as the interface between microfinance institutions and clients, and as previous
research has shown, they are particularly relevant in the screening and recovery phases.
Given that these two stages of the credit process are considered critical in over-indebtedness
prevention strategies, it is expected that credit officers have a key role at this level. However,
the case study developed at Banco ADOPEM based on field observations and statistical
analysis of data collected from the institution?s management information system showed that
for ADOPEM there were institutional factors outweighing the individual influence of loan officers.
Among them, the human resources? policies and the standardization of procedures were
vital and helped build a strong corporate culture.
MODELLING NITROGEN DYNAMICS IN CROP AND SOIL: FROM SITE-SPECIFIC TO REGIONAL APPLICATION IN NORTHERN ITALY.
Creators: name: PEREGO, ALESSIA
Publisher: name: Universit� degli Studi di Milano
Year: 2011

description: The aim of my Ph.D. work was to investigate the main factors related to N leaching from arable land under different pedoclimatic conditions and cropping systems in Lombardia plain. In situ monitoring and modelling analysis were defined to evaluate the potential N losses via leaching from arable land and the effect of agricultural management. At monitoring sites, representative of Lombardia arable land, data of soil, crop, water, and N-related variables were collected for a period from 2 to 5 years. Soil characterization, crop yield, leaf area index, harvest index, crop nitrogen uptake, soil water content and soil solution nitrogen concentration at different depths were measured over the monitoring period.
All the collected data were used to calibrate and validate the ARMOSA model. Such dynamic model was developed by our research team to predict N leaching risk from arable land in northern Italy. The calibration and validation procedures allowed to parameterize (i) pedological parameters related to soil water balance and nitrogen dynamics, such as mineralization, denitrification, volatilization, wet and dry atmospheric deposition, immobilization; (ii) six crops growth and development parameters which lead the gross assimilation of CO2, leaf area index, stem and root elongation, respiration loss, nitrogen dilution curve, crop development based on growing degree days, dry matter partitioning, evapotranspiration and residuals calculation. The outstanding result was that crop, water and N-related variables were accurately simulated, being in full agreement with observed data.
Once calibrated and validated, ARMOSA model was applied at regional scale in order to evaluate the potential risk of N leaching. The model run over 20 years in 35 simulation units, obtained by dividing Lombardia plain in homogenous districts in terms of pedological, climatic and cropping systems features. Each district was characterized by two representative soil types, meteorological observed data set, crop rotations according to the regional land use analysis, organic N load, calculated on the basis of livestock density.
With regard to results, similar or even higher N use efficiency resulted with increasing organic N supply and proportionally reduced mineral fertilization. In such way, N leaching decreased by half in maize-based forage systems. Moreover, the eventual choice to introduce a catch crop in rotation strongly contributed to minimize N leaching.
MICROVESICLES: MESSENGERS AND MEDIATORS OF NEUROINFLAMMATION
Creators: name: TUROLA, ELENA
Publisher: name: Universit� degli Studi di Milano
Year: 2012

description: Extracellular microvesicles (MVs) have been indicated as a way of intercellular communication and are emerging as new biomarkers of tissue damage. We have recently shown that microglia, upon in vitro activation, shed MVs containing pro-inflammatory cytokines. .Here we show that microglia derived MVs deliver a proinflammatory signal in vitro to neighbouring cells, microglia, astrocytes and also neuron. We also show that rodent and human cerebrospinal fluid (CSF) contain MVs of microglia origin, similar to those released in vitro by ATP-activated microglia. Flow cytometry analysis indicated increased levels of microglia-derived MVs in the CSF of mice intracerebrally injected with lentiviral vectors codifying for IFN? or TNF?, a protocol known to induce dramatic activation of microglia/macrophages. These results represent the proof of principle that the amount of MVs in the CSF reflects the activation state of microglia in vivo and thus the extent of the inflammatory condition. In line with these data microglia MVs also increased in rodent CSF in the course of Experimental Autoimmune Encephalomyelitis (EAE), a widely used model for the inflammatory human disease multiple sclerosis (MS). In both chronic and relapsing EAE, the number of microglia-derived MVs was closely associated to disease course, increasing with EAE severity and decreasing with recovery. To verify if microglia MVs were similarly modulated in humans, we collected CSF from healthy donors, and MS patients. Elevated levels of microglia MVs were detected in the CSF collected from MS patients. To define whether microglia MVs contribute to neuroinflammation in vivo MVs were stereotaxically injected into the corpus callosum, a site usually devoid of inflammation. In addition, EAE was induced in acid spingomyelinase knock out mice, which are genetically impaired in MVs release. In vivo MVs administration induced an inflammatory response at the site of injection, while mice impaired in MVs shedding were protected from experimental. Altogether these findings identify microglia-derived MVs as novel biomarker and therapeutic target in brain inflammation.
Fast Timing Detectors for Prompt Gamma Time Imaging
Creators: name: Marcatili, Sara
name: Pinson, Maxime
name: hoarau, christophe
name: Kavrigin, Pavel
name: Gallin-Martel, Marie-Laure
name: MURAZ, Jean-Francois
name: Gallin-Martel, Laurent
name: BOURSIER, YANNICK
name: Cherni, Afef
name: Dupont, Mathieu
name: Garnier, Alicia
name: Hérault, Joël
name: Hofverberg, Petter
name: Maneval, Daniel
name: Morel, Christian
Publisher: name: Zenodo
Year: 2024

description: Presentation at PSMR2024.
Additional file 2 of Factors influencing hospitalization or emergency department visits and mortality in type 2 diabetes following the onset of new cardiovascular diagnoses in a population-based study
Creators: name: Agvall, Björn
name: Jonasson, Junmei Miao
name: Galozy, Alexander
name: Halling, Anders
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Cancer

description: Supplementary Material 2
Titel: Assessment of sustainable tourism development in Windhoek, Namibia : Development and implementation of an adapted criteria catalogue in line with respective local conditions.
Creators: name: Eckert, Elena
Publisher: name: Hochschule Bremen
Year: 2020
Subjects: subject: sustainable tourism
subject: destination management
subject: sustainability assessment
subject: Windhoek
subject: Namibia
subject: cultural heritage
subject: tourism strategy
subject: 80

description: The aim of this master thesis is to assess, analyse and evaluate the sustainability of a tourism destination while taking the local conditions into consideration by adapting the assessment instrument. The case study of the city Windhoek in Namibia is used to identify particular local features and make them measurable using an adapted criteria catalogue. In addition to a comprehensive secondary analysis, the database consists of different qualitative and quantitative methods, which are conducted during a field research phase in the form of expert interviews, visitor and local surveys and observations at relevant POIs. The content and statistical evaluation of the data is the basis for the assessment of the indicators, the sustainability dimensions and the global evaluation of sustainability in the destination. The weaknesses identified in the course of the research are then recorded in the form of recommended actions. As this thesis is part of the development policy cooperation between the City of Bremen and the City of Windhoek, the communication platform, to make the research results available to the City of Windhoek, has been established. Besides the adaptation of the catalogue, a refinement of the method for future measurement and evaluation of sustainability in destinations with different framework conditions is developed. Based on a critical reflection and the issue of the applicability of the model to other destinations, technical and content-related recommendations for the catalogue adaptation to local circumstances are made.
title: Naturschutz und Natursport im Konflikt - Das Beispiel Kitesurfen im Naturpark Steinhuder Meer
title: The Conflict of Nature Conservation and Sports - An Example of Kitesurfing at the Steinhuder Meer Natural Preserve
titleType: AlternativeTitle
Creators: name: Mentz, Elena
Publisher: name: Hochschule Bremen
Year: 2021
Subjects: subject: Konflikt
subject: Naturschutz
subject: Natursport
subject: Kitesurfen
subject: Spannungsfeld
subject: 300

description: Die vorliegende Bachelorarbeit bietet einen tiefgreifenden Einblick in das komplexe und komplizierte Konfliktfeld Naturschutz – Natursport. Dabei wird nach Problemen, Ursachen und Möglichkeiten zur Lösung von Konflikten zwischen Akteuren des Naturschutzes und Natursportlern geforscht. Nachdem anhand einer Sekundäranalyse wesentliche Begriffe definiert und theoretische Grundlagen für eine Konfliktanalyse geschaffen wurden, erfolgt eine praktische Anwendung von sozialwissenschaftlichen Konfliktforschungsmethoden auf ein Fallbeispiel, das Kitesurfen im Naturpark Steinhuder Meer. Durch Interviews mit ausgewählten Experten wird eine Datengrundlage geschaffen und systematisch ausgewertet. Von den Ergebnissen der Sekundär- und Primärforschung ausgehend, kann eingeschätzt werden, dass aufgrund gegensätzlicher Ziele und verschiedener Ansprüche an einen Raum vor allem Kommunikations- und Informationsdefizite für Konflikte zwischen Naturschutz und Natursport verantwortlich sind. Zwar ist grundsätzlich der Kompromiss die einzige und effektivste Konfliktlösungsstrategie, doch können noch weitere Faktoren als hilfreiche Leitlinien bestimmt werden, die für Konflikte in Schutzgebieten richtungsweisend sind.