cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
(1756) Charlotte Rhodes
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Curved Radio Spectra of Weak Cluster Shocks
Creators: name: Kang, Hyesung
name: Ryu, Dongsu
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: In order to understand certain observed features of arc-like giant radio relics such as the rareness, uniform surface brightness, and curved integrated spectra, we explore a diffusive shock acceleration (DSA) model for radio relics in which a spherical shock impinges on a magnetized cloud containing fossil relativistic electrons. Toward this end, we perform DSA simulations of spherical shocks with the parameters relevant for the Sausage radio relic in cluster CIZA J2242.8+5301, and calculate the ensuing radio synchrotron emission from re-accelerated electrons. Three types of fossil electron populations are considered: a delta-function like population with the shock injection momentum, a power-law distribution, and a power-law with an exponential cutoff. The surface brightness profile of radio-emitting postshock region and the volume-integrated radio spectrum are calculated and compared with observations. We find that the observed width of the Sausage relic can be explained reasonably well by shocks with speed $u_s \sim 3\times 10^3 \kms$ and sonic Mach number $M_s \sim 3$. These shocks produce curved radio spectra that steepen gradually over $(0.1-10) ν_{\rm br}$ with break frequency $ ν_{\rm br}\sim 1$ GHz, if the duration of electron acceleration is $\sim 60 - 80$ Myr. However, the abrupt increase of spectral index above $\sim 1.5$ GHz observed in the Sausage relic seems to indicate that additional physical processes, other than radiative losses, operate for electrons with $γ_e \gtrsim 10^4$.
description: accepted for publication in ApJ
D2.3 Big Data Fusion Module
Creators: name: Aristotle University Of Thessaloniki
name: Idener
Publisher: name: Zenodo
Year: 2022
Subjects: AGRICORE H2020

description: AGRICORE is a research project funded by the European Commission under the RUR-04-2018 call, part of the H2020 programme, which proposes an innovative way to apply agent-based modelling to improve the capacity of policymakers to evaluate the impact of agricultural-related measurements under and outside the framework of the Common Agricultural Policy (CAP). This deliverable presents the AGRICORE data fusion module, which allows the integration and blending of individual datasets (previously obtained by the data extraction module) to constitute enriched datasets that are used for the operation of the different AGRICORE modules. The main data fusion operation required for the implementation of an AGRICORE use case is the one needed for producing the synthetic agents representing the agricultural and livestock holdings under study. Specifically, a mathematical artefact is needed to generate the values then assigned to the attributes that make up each of agent. The mathematical tool chosen to perform this function is the Bayesian Network (BN). This deliverable introduces the Bayesian Network construction algorithm(s) that have been developed and or improved to be used within the AGRICORE project. In order to test these algorithm(s), four synthetic samples of farms have been generated in three NUTS2 regions and one NUTS3 sub-region of Greece. This deliverable presents these example cases including the aggregations of specific variables, the structure of the resulting BN for each case, and the evaluation of the fit of the generated synthetic sample with respect to the real baseline sample.
KIBERXAVFSIZLIKNING BUGUNGI KUNDAGI O`RNI
Creators: name: Mamarajabov, Husan
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqola kiberxavfsizlikning bugungi kunda ahamiyatini, uning zamonaviy jamiyatdagi roli, afzalliklari va kamchiliklarini tahlil qiladi. Kiberxavfsizlik nafaqat korporativ yoki davlat darajasida, balki shaxsiy foydalanuvchilar uchun ham muhimdir. Maqola, kiberxavfsizlikning rivojlanishi, mavjud xavflar va ularni bartaraf etish usullari haqida xulosa beradi.
Supplementary Figure S1: scenarios with logistic growth from Variability in life-history switch points across and within populations explained by Adaptive Dynamics.
Creators: name: Landi, Pietro
name: Vonesh, James R.
name: Hui, Cang
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60114 Systems Biology
subject: 60199 Biochemistry and Cell Biology not elsewhere classified
subject: 69999 Biological Sciences not elsewhere classified
subject: 10202 Biological Mathematics
subject: FOS: Mathematics

description: Scenarios for time of maturation under different juvenile initial sizes computed with logistic growth function w(τ)=g(w0,τ)= w0wK exp(rτ)/(wK+w0(exp(rτ)-1)). Orange interval: internal Evolutionary Stable Strategy (ESS) 0K=10. Dark green interval: branching point (within-population variability). Light green interval: either branching point or boundary strategy τ=0 (across- and within-population variability). Red interval: direct development. Solid line: convergence stable equilibria (attracting strategies). Dashed line: convergence unstable equilibria (repelling strategies). Thick line: convergence stable but evolutionary unstable equilibria (branching points). TC: transcritical bifurcation. BR: branching bifurcation (B=0 in equation (6) in the main text), turning selection disruptive. SN: saddle-node bifurcation.;Model implementation
NFFA-Europe Pilot - D13.1 - NEP Session at EMRS Meeting (Workshop on advanced lithography and nanopatterning)
Creators: name: Perez-Murano, Francesc
name: Maximov, Ivan
Publisher: name: Zenodo
Year: 2022

description: This deliverable report summarizes the main aspects of the workshop that took place at EMRS 2022 Spring Meeting, which was hold on-line May 30 and May 31. All the workshop information is stored at the E-MRS website:https://www.european-mrs.com/new-trends-advanced-lithography-and-patterntransfer-methods-emrs
description: WP13 - Nano-Engineering and pattern transfer methods
Tunneling time in attosecond experiments and time-energy uncertainty relation
Creators: name: Kullie, Ossama
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In this work we present a theoretical model supported with a physical reasoning leading to a relation which performs an excellent estimation for the tunneling time in attosecond and strong field experiments, where we address the important case of the He-atom \cite{Eckle:2008s,Eckle:2008}. Our tunneling time estimation is found by utilizing the time-energy uncertainty relation and represents a quantum clock. The tunneling time is also featured as the time of passage (at the exit of the tunnel) similarly to the Einstein's {\it photon box Gedanken experiment}. Our work tackles an important study case for the theory of time in quantum mechanics and is very promising for the search for a (general) time operator in quantum mechanics. The work can be seen as a new fundamental step in dealing with the tunneling time in strong field and ultra-fast science, and is appealing for more elaborate treatments using quantum wave packet dynamics and especially for complex atoms and molecules.
description: Article is also submiited to Phys. Rev. A
(1750) Roger Scarlett
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
p53 Binds Telomeric Single Strand Overhangs and t-Loop Junctions in Vitro
Creators: name: Griffith, Jack D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: The interaction of p53 with a human model telomere in vitro was examined by electron microscopy. p53 demonstrated a sequence-independent affinity for telomeric DNA in vitro, localizing to the 3' single strand overhang and the t-loop junction both in the presence and absence of associated TRF2. Binding was not observed above background along the duplex telomeric repeats. However, the efficiency of TRF2-catalyzed t-loop formation on the model DNA was increased 2-fold in the presence of p53 although a variety of single strand or Holliday junction-binding proteins did not facilitate t-loop formation. These results suggest that p53 has an active role in telomere maintenance and structure through association with the t-loop junction.
(1751) James Brown
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Zum Gedenken an Hanny Fries, [27.11.1918 - 07.12.2009]
title: Reden, gehalten anlässlich der Trauerfeier vom 16. Dezember 2009 im Fraumünster Zürich
titleType: Subtitle
Creators: name: Knellwolf, Ulrich
name: Fries, Hanny
Publisher: name: Stiftung Hanny Fries und Beno Blumenstein
Year: 2010
Subjects: subject: 920 Biografien, Genealogie, Insignien
subject: Fries, Hanny
subject: Nachruf
subject: Zürich
subject: Fraumünster (Zürich)

description: Mit Beiträgen von Ulrich Knellwolf, Susanna Schwager, Guido Magnaguagno, Werner Morlang, Rudi Bindella, Josef Estermann ; enthält zudem einen Auszug aus einem Brief sowie Bilder von Hanny Fries
The integrated periodogram of a dependent extremal event sequence
Creators: name: Mikosch, Thomas
name: Zhao, Yuwei
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics

description: We investigate the asymptotic properties of the integrated periodogram calculated from a sequence of indicator functions of dependent extremal events. An event in Euclidean space is extreme if it occurs far away from the origin. We use a regular variation condition on the underlying stationary sequence to make these notions precise. Our main result is a functional central limit theorem for the integrated periodogram of the indicator functions of dependent extremal events. The limiting process is a continuous Gaussian process whose covari- ance structure is in general unfamiliar, but in the iid case a Brownian bridge appears. In the general case, we propose a stationary bootstrap procedure for approximating the distribution of the limiting process. The developed theory can be used to construct classical goodness-of-fit tests such as the Grenander- Rosenblatt and Cramér-von Mises tests which are based only on the extremes in the sample. We apply the test statistics to simulated and real-life data.
Phospholipase C-γ Modulates Epithelial Tight Junction Permeability through Hyperphosphorylation of Tight Junction Proteins
Creators: name: Thakker, Dhiren R.
name: Troutman, Matthew D.
name: Ward, Peter D.
name: Klein, Ryan R.
name: Desai, Shaleish
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Phospholipase C-gamma (PLC-gamma) is stimulated by epidermal growth factor via activation of the epidermal growth factor receptors. The PLC inhibitor, 3-nitrocoumarin (3-NC), selectively inhibited PLC-gamma in Madin-Darby canine kidney cells without affecting the activity of PLC-beta. In contrast, inhibitors of PLC-beta, hexadecylphosphocholine and, had no effect on the activity of PLC-gamma. Inhibition of PLC-gamma by 3-NC was associated with an increase in tight junction permeability across Madin-Darby canine kidney cell monolayers, as evidenced by 3-NC-induced decrease in transepithelial electrical resistance and increase in mannitol flux over a concentration range that was inhibitory to PLC-gamma. An analog of 3-NC, 7-hydroxy-3-NC (7-OH-3-NC), which was inactive as an inhibitor of PLC-gamma, also had no effect on tight junction permeability. Treatment with 3-NC caused punctate disruption in the cortical actin filaments. The PLC-gamma inhibitor, 3-NC, but not the inactive analog, 7-OH-3-NC, caused hyperphosphorylation of the tight junction proteins, occludin, ZO-1, and ZO-2. The serine/threonine kinase inhibitor, staurosporine (50-200 nm), significantly attenuated 3-NC-induced hyperphosphorylation of ZO-2. This corresponded with attenuation by staurosporine of 3-NC-induced increase in tight junction permeability, suggesting a relationship between ZO-2 phosphorylation and tight junction permeability.
Categorifying the magnitude of a graph
Creators: name: Hepworth, Richard
name: Willerton, Simon
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: Algebraic Topology (math.AT)
subject: Category Theory (math.CT)
subject: FOS: Mathematics
subject: 55N35, 05C31

description: The magnitude of a graph can be thought of as an integer power series associated to a graph; Leinster introduced it using his idea of magnitude of a metric space. Here we introduce a bigraded homology theory for graphs which has the magnitude as its graded Euler characteristic. This is a categorification of the magnitude in the same spirit as Khovanov homology is a categorification of the Jones polynomial. We show how properties of magnitude proved by Leinster categorify to properties such as a Kunneth Theorem and a Mayer-Vietoris Theorem. We prove that joins of graphs have their homology supported on the diagonal. Finally, we give various computer calculated examples.
description: 29 pages, one figure and many tables. v2: minor changes
R Notebook of S1 from Quantitative characterization of iridescent colours in biological studies: a novel method using optical theory
Creators: name: Gruson, Hugo
name: Andraud, Christine
name: WillyDaney DeMarcillac
name: Berthier, Serge
name: Elias, Marianne
name: Gomez, Doris
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Biophysics
subject: Environmental Science
subject: 90301 Biomaterials
subject: FOS: Medical engineering

description: R Notebook containing the code used in our worked example presented in S1. All necessary data to run the code and test the method yourself is provided as well.
Analytic expression for three-body recombination rates into deep dimers
Creators: name: Fedorov, D. V.
name: Mikkelsen, M.
name: Jensen, A. S.
name: Zinner, N. T.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We investigate three-body recombination rates into deep dimers in cold atomic gases with large scattering length within hyper-spherical adiabatic zero-range approach. We derive closed analytic expressions for the rates for one- and two-species gases. Although the deep dimers are beyond the zero-range theory the latter can still describe the recombination into deep dimers by use of one additional short-range absorption parameter. The recombination rate, as function of the scattering length, retains the known universal behavior --- the fourth power trend with characteristic log-periodic peaks --- however increasing the short-range absorption broadens the peaks until they are eventually completely smeared out. Increasing the heavy-to-light mass ratio in a two-species system decreases the distance between the peaks and increases the overal scale of the recombination rate.
description: 8 pages, 5 figures, Conference "Systems on the verge of the stability" (Critical Stability 2014)
Protein Inhibitors of Activated STAT Resemble Scaffold Attachment Factors and Function as Interacting Nuclear Receptor Coregulators
Creators: name: Hamil, Katherine G.
name: French, Frank S.
name: Petrusz, Peter
name: Hall, Susan H.
name: Tan, Jiann An
name: Grossman, Gail
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Protein inhibitor of activated STAT1 (PIAS1) functions as a nuclear receptor coregulator and is expressed in several cell types of human testis. However, the mechanism of PIAS1 coregulation is unknown. We report here that PIAS1 has characteristics of a scaffold attachment protein. PIAS1 localized in nuclei in a speckled pattern and bound A-T-rich double-stranded DNA, a function of scaffold attachment proteins in chromatin regions of active transcription. DNA binding was dependent on a 35-amino acid sequence conserved among members of the PIAS family and in scaffold attachment proteins. The PIAS family also bound the androgen receptor DNA binding domain, and binding required the second zinc finger of this domain. PIAS1 contained an intrinsic activation domain but had bi-directional effects on androgen receptor transactivation; lower expression levels inhibited and higher levels increased transactivation in CV1 cells. Other PIAS family members also had dose-dependent effects on transactivation, but they were in a direction opposite to those of PIAS1. When coexpressed with PIAS1, other PIAS family members counteracted PIAS1 coregulation of androgen receptor transactivation. The interaction of PIAS1 with other members of the PIAS family suggests a transcription coregulatory mechanism involving a multicomponent PIAS nuclear scaffold.
(1753) Hugh Lonsdale Brooksbank
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: The Christian churches in the Soviet Occupied Zone and the GDR, 1945-1989
Creators: name: Gehrold, Sebastian Michael
Publisher: name: University of Glasgow
Year: 1997
Subjects: subject: Religious history, European history.

description: This dissertation deals with the Christian Churches in the Soviet Occupied Zone and the GDR, 1945-1989. It consists of three main sections, with the first part providing background information, the second part focusing on the actual topic, and the third part comparing and analysing the previously reached results. The first part of the dissertation is sub-divided into three chapters. Chapter one deals with the German churches 1918-1945. The aim of this chapter is to provide in insight into the roles Protestantism and Catholicism played before Hitler came to power in 1933. The major changes of the 15 years after the First World War are elaborated and the churches' attempts to accommodate themselves under the various political systems are analysed. The second chapter of part one deals with the Christian churches in eastern Europe after the Second World War. Background information on the Communist governments' church policies is provided and patterns are established in order to allow comparison with the situation in the GDR. The last chapter of this part focuses on the Vatican's eastern policies. The approaches pursued by the various pontiffs and the consequences that the Vatican's policies had on the Catholics in eastern Europe are pointed out. Again, the aim is to establish a background against which the situation in the GDR can be compared. Part two of this dissertation is dedicated to the churches under Soviet military administration and the GDR. The first chapter analyses the period 1945-1949, when the foundations for the state/church relationship in the GDR were laid. The second chapter elaborates the changes in the GDR government's church policy over the first twenty years (until 1969), and points out the churches' diverse responses. The phase after 1969/70, is tackled in chapter three. This chapter also includes the 1980s, which bring the stagnation of the GDR and finally the collapse of the regime. The third part of this work, the conclusion, begins with an analysis of the Christians' contribution to the 1989 revolution. This is followed by a section that points out the similarities and differences between the GDR and the other eastern European countries in regard to their church policies. The final chapter also compares the role of the Protestantism and Catholicism in the GDR, and tries to evaluate their responses to the totalitarian challenge.
Imaging the Uptake and Effects of Microplastics on Organisms by Coherent Raman Scattering Microscopy
Creators: name: Düwel, Julian
name: Pilger, Christian
name: Liese, B.
name: Stock, N.
name: Müller, C.
name: Huser, Thomas
Publisher: name: Zenodo
Year: 2023

description: In order to determine the effects that the uptake of microplastics has on various organisms, novel means of detecting and imaging microplastics inside cells and organisms are needed. In the best case, such methods should provide entirely label-free contrast, while still being chemically specific. In optical microscopy, this is best realized by utilizing Raman scattering, which is the inelastic scattering of light at molecular bonds. While spontaneous Raman scattering is too slow for most imaging applications, coherent Raman scattering (CRS) can be employed at imaging speeds up to video-rate. We have developed and employed a fully customizable CRS microscope, which allows us to visualize the structure of organic and biological samples in the same imaging process as the identification and imaging of microplastics in these samples. This system allows us to analyze a wide range of effects of the uptake of microplastics, e.g. by plant seedling up to monitoring fitness parameters, such as lipid concentration in C. elegans nematodes. A variety of techniques are combined in one setup. These techniques include coherent anti-Stokes Raman scattering (CARS) and stimulated Raman scattering (SRS) using optical parametric oscillators to probe different Raman resonances, as well as second harmonic generation (SHG) to probe tissue structure. This gives us the opportunity to use a wide range of analysis techniques to collect information with biological and medical relevance. These methods include volumetric imaging and hyperspectral analysis to produce quantitative data about the composition of the examined samples. In this contribution we will provide detailed information about the setup and recent improvements, and demonstrate its wide range of applications with particular emphasis on analyzing the effects of microplastics uptake by organisms.
PTEN Blocks Tumor Necrosis Factor-induced NF-κB-dependent Transcription by Inhibiting the Transactivation Potential of the p65 Subunit
Creators: name: Whang, Young E.
name: Yuan, Xiu Juan
name: Madrid, Lee V.
name: Baldwin, Albert S.
name: Jones, David R.
name: Westerheide, Sandy D.
name: Mayo, Marty W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: PTEN is a lipid phosphatase responsible for down-regulating the phosphoinositide 3-kinase product phosphatidylinositol 3,4,5-triphosphate. Phosphatidylinositol 3,4,5-triphosphate is involved in the activation of the anti-apoptotic effector target, Akt. Although the Akt pathway has been implicated in regulating NF-kappaB activity, it is controversial as to whether Akt activates NF-kappaB predominantly through mechanisms that regulate nuclear translocation or transactivation potential. In this report, we utilized PTEN as a natural biological inhibitor of Akt activity to study the effects on tumor necrosis factor (TNF)-induced activation of NF-kappaB. We found that the reintroduction of PTEN into prostate cells inhibited TNF-stimulated NF-kappaB transcriptional activity. PTEN failed to block TNF-induced IKK activation, IkappaBalpha degradation, p105 processing, p65 (RelA) nuclear translocation, and DNA binding of NF-kappaB. However, PTEN inhibited NF-kappaB-dependent transcription by blocking the ability of TNF to stimulate the transactivation domain of the p65 subunit. PTEN also inhibited the transactivation potential of the cyclic AMP-response element-binding protein, but this was not observed for c-Jun. The transactivation potential of p65 following TNF stimulation could be rescued from PTEN-dependent repression by re-introducing expression constructs encoding activated forms of phosphoinositide 3-kinase, Akt, or Akt and IKK. The ability of PTEN to inhibit the TNF-induced transactivation function of p65 is important, because expression of PTEN blocked TNF-stimulated NF-kappaB-dependent gene expression, thus sensitizing cells to TNF-induced apoptosis. Maintenance of the PTEN tumor suppressor protein is therefore required to modulate Akt activity and to concomitantly control the transcriptional activity of the anti-apoptotic transcription factor NF-kappaB.
Supplementary table and figures from Pectoral girdle and forelimb musculoskeletal function in the echidna (Tachyglossus aculeatus): insights into mammalian locomotor evolution
Creators: name: Regnault, Sophie
name: Pierce, Stephanie E.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 110601 Biomechanics
subject: FOS: Health sciences

description: File contains supplementary Table S1 and Figures S1-S6
Raf-independent Deregulation of p38 and JNK Mitogen-activated Protein Kinases Are Critical for Ras Transformation
Creators: name: Pruitt, Kevin
name: Westwick, John K.
name: Pruitt, Wendy M.
name: Der, Channing J.
name: Bilter, Graham K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Activated Ras, but not Raf, causes transformation of RIE-1 epithelial cells, supporting the importance of Raf-independent pathways in mediating Ras transformation. The p38 and JNK mitogen-activated protein kinase cascades are activated by Ras via Raf-independent effector function. Therefore, we determined whether p38 and JNK activation are involved in Ras transformation of RIE-1 epithelial cells. Rather surprisingly, we found that pharmacologic inhibition of p38, together with Raf activation of ERK, was sufficient to mimic the morphologic and growth transformation caused by oncogenic Ras. p38 inhibition together with ERK activation also caused the same alterations in cyclin D1 and p21(CIP1) expression caused by Ras and induced an autocrine growth factor loop important for transformation. Finally, in contrast to p38, we found that JNK activation promoted Ras transformation, and that Ras deregulation of p38 and JNK was not mediated by activation of the Rac small GTPase. We conclude that a key action of Raf-independent effector pathways important for Ras transformation may involve inhibition of p38 and activation of JNK.
SGPW - SSA Bulletin 31 (2019)
Creators: name: Kölliker, Roland
Publisher: name: Zenodo
Year: 2019

description: Diversität in der Forschung für einen vielfältigen Pflanzenbau Zusammenfassung der Vorträge der 27. Jahresversammlung der Schweiz. Gesellschaft für Pflanzenbauwissenschaften SGPW-SSA
Supplementary Figure S1: scenarios with logistic growth from Variability in life-history switch points across and within populations explained by Adaptive Dynamics
Creators: name: Landi, Pietro
name: Vonesh, James R.
name: Hui, Cang
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60114 Systems Biology
subject: 60199 Biochemistry and Cell Biology not elsewhere classified
subject: 69999 Biological Sciences not elsewhere classified
subject: 10202 Biological Mathematics
subject: FOS: Mathematics

description: Scenarios for time of maturation under different juvenile initial sizes computed with logistic growth function w(τ)=g(w0,τ)= w0wK exp(rτ)/(wK+w0(exp(rτ)-1)). Orange interval: internal Evolutionary Stable Strategy (ESS) 0K=10. Dark green interval: branching point (within-population variability). Light green interval: either branching point or boundary strategy τ=0 (across- and within-population variability). Red interval: direct development. Solid line: convergence stable equilibria (attracting strategies). Dashed line: convergence unstable equilibria (repelling strategies). Thick line: convergence stable but evolutionary unstable equilibria (branching points). TC: transcritical bifurcation. BR: branching bifurcation (B=0 in equation (6) in the main text), turning selection disruptive. SN: saddle-node bifurcation.;Model implementation
RasGRP4 Is a Novel Ras Activator Isolated from Acute Myeloid Leukemia
Creators: name: Caligiuri, Michael A.
name: Rebhun, John F.
name: Reuther, Gary W.
name: Der, Channing J.
name: Quilliam, Lawrence A.
name: Lambert, Que T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Although a number of genetic defects are commonly associated with acute myeloid leukemia (AML), a large percentage of AML cases are cytogenetically normal. This suggests a functional screen for transforming genes is required to identify genetic mutations that are missed by cytogenetic analyses. We utilized a retrovirus-based cDNA expression system to identify transforming genes expressed in cytogenetically normal AML patients. We identified a new member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors, designating it RasGRP4. Subsequently, cDNA sequences encoding rodent and human RasGRP4 proteins were deposited in GenBank. RasGRP4 contains the same protein domain structure as other members of the RasGRP family, including a Ras exchange motif, a CDC25 homology domain, a C1/diacyglycerol-binding domain, and putative calcium-binding EF hands. We show that expression of RasGRP4 induces anchorage-independent growth of Rat1 fibroblasts. RasGRP4 is a Ras-specific activator and, interestingly, is highly expressed in peripheral blood leukocytes and myeloid cell lines. Unlike other RasGRP proteins, RasGRP4 is not expressed in the brain or in lymphoid cells. We demonstrated that 32D myeloid cells expressing RasGRP4 have elevated levels of activated Ras compared with control cells, and phorbol 12-myristate 13-acetate (PMA) treatment greatly enhanced Ras activation. PMA induced membrane localization of RasGRP4 and 32D cells expressing RasGRP4 were capable of cytokine-independent proliferation in the presence of PMA. We conclude that RasGRP4 is a member of the RasGRP family of Ras guanine nucleotide exchange factors that may play a role in myeloid cell signaling growth regulation pathways that are responsive to diacylglycerol levels.
Fast Hadamard transforms for compressive sensing of joint systems: measurement of a 3.2 million-dimensional bi-photon probability distribution
Creators: name: Lum, Daniel J.
name: Knarr, Samuel H.
name: Howell, John C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We demonstrate how to efficiently implement extremely high-dimensional compressive imaging of a bi-photon probability distribution. Our method uses fast-Hadamard-transform Kronecker-based compressive sensing to acquire the joint space distribution. We list, in detail, the operations necessary to enable fast-transform-based matrix-vector operations in the joint space to reconstruct a 16.8 million-dimensional image in less than 10 minutes. Within a subspace of that image exists a 3.2 million-dimensional bi-photon probability distribution. In addition, we demonstrate how the marginal distributions can aid in the accuracy of joint space distribution reconstructions.
Receptor-selective Effects of Endogenous RGS3 and RGS5 to Regulate Mitogen-activated Protein Kinase Activation in Rat Vascular Smooth Muscle Cells
Creators: name: Wang, Qin
name: Siderovski, David P.
name: Neubig, Richard R.
name: Liu, Min
name: Mullah, Bashar
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Regulators of G protein signaling (RGS) proteins compose a highly diverse protein family best known for inhibition of G protein signaling by enhancing GTP hydrolysis by Galpha subunits. Little is known about the function of endogenous RGS proteins. In this study, we used synthetic ribozymes targeted to RGS2, RGS3, RGS5, and RGS7 to assess their function. After demonstrating the specificity of in vitro cleavage by the RGS ribozymes, rat aorta smooth muscle cells were used for transient transfection with the RGS-specific ribozymes. RGS3 and RGS5 ribozymes differentially enhanced carbachol- and angiotensin II-induced MAP kinase activity, respectively, whereas RGS2 and RGS7 ribozymes had no effect. This enhancement was pertussis toxin-insensitive. Thus RGS3 is a negative modulator of muscarinic m3 receptor signaling, and RGS5 is a negative modulator of angiotensin AT1a receptor signaling through G(q/11). Also, RGS5 ribozyme enhanced angiotensin-stimulated inositol phosphate release. These results indicate the feasibility of using the ribozyme technology to determine the functional role of endogenous RGS proteins in signaling pathways and to define novel receptor-selective roles of endogenous RGS3 and RGS5 in modulating MAP kinase responses to either carbachol or angiotensin.
PEDAGOGICAL STRATEGIES FOR FOSTERING CRITICAL THINKING AND PROBLEM-SOLVING SKILLS
Creators: name: Kalbaeva, Tumaris
Publisher: name: Zenodo
Year: 2023

description: This thesis explores the imperative role of pedagogical strategies in cultivating critical thinking and problem-solving skills among learners. With an ever-evolving educational landscape and an increasing demand for adaptable and analytical thinkers, this study investigates a spectrum of pedagogical methods.
(1746) Mary Williams
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Regulation of Insulin-like Growth Factor I Receptor Dephosphorylation by SHPS-1 and the Tyrosine Phosphatase SHP-2
Creators: name: Clemmons, David R.
name: Maile, Laura A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Activation of insulin-like growth factor I receptor (IGF-IR) kinase is an important site of control of IGF-I-linked intracellular signaling pathways. One potentially important regulatory variable is IGF-IR dephosphorylation. It has been shown that SHP-2, a tyrosine phosphatase, can bind to the activated IGF-IR in vitro; however, its role in IGF-IR dephosphorylation in whole cells is unknown. These studies were undertaken to determine whether SHP-2 was a candidate for mediating IGF-IR dephosphorylation. The IGF-IR in smooth muscle cells was dephosphorylated rapidly beginning 10 min after ligand addition, and this was temporally associated with SHP-2 binding to the receptor. IGF-I stimulated SHPS-1 phosphorylation and the subsequent recruitment of SHP-2. In cells expressing a SHPS-1 mutant that did not bind SHP-2 there was no recruitment of SHP-2 to the IGF-IR. Cells expressing a catalytically inactive form of SHP-2 showed SHP-2 recruitment to SHPS-1, but this did not result in SHPS-1 dephosphorylation, and there was a prolonged IGF-IR phosphorylation response after IGF-I stimulation. These studies indicate that IGF-IR stimulates phosphorylation of SHPS-1 which is critical for SHP-2 recruitment to the plasma membrane and for its recruitment to the IGF-IR. Recruitment of SHP-2 to the receptor then results in receptor dephosphorylation. The regulation of this process may be an important determinant of IGF-IR-mediated signaling.
Methods and Figures from Contrasting evolutionary history, anthropogenic declines and genetic contact in the northern and southern white rhinoceros (Ceratotherium simum).
Creators: name: Yoshan Moodley
name: Isa-Rita M. Russo
name: Robovský, Jan
name: Desiré L. Dalton
name: Kotzé, Antoinette
name: Smith, Steve
name: Stejskal, Jan
name: Ryder, Oliver A.
name: Hermes, Robert
name: Walzer, Chris
name: Bruford, Michael W.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology

description: MS Word file of supplementary methods and figures.
Calculation of the Dimer Equilibrium Constant of Heavy Water Saturated Vapor
Creators: name: Bulavin, L. A.
name: Khrapatiy, S. V.
name: Makhlaichuk, V. N.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Water is the most common substance on Earth.The discovery of heavy water and its further study have shown that the change of hydrogen for deuterium leads to the significant differences in their properties.The triple point temperature of heavy water is higher,at the same time the critical temperature is lower.Experimental values of the second virial coefficient of the EOS for the vapor of normal and heavy water differ at all temperatures.This fact can influence the values of the dimerization constant for the heavy water vapor.The equilibrium properties of the dimerization process are described with the methods of chemical thermodynamics.The chemical potentials for monomers (m) and dimers (d)are the functions of their concentrations.The interactions of monomer-dimer and dimer-dimer types are taken into account within the solution of equation for chemical potentials.The obtained expression for the dimerization constant contains the contributions of these types.The averaged potentials are modeled by the Sutherland potential.Theoretical values of the dimerization constant for the heavy water vapor at different temperatures are compared to those for normal water.We see the exceeding of the values for the heavy water at all temperatures.This fact is in good agreement with all experimental data that is available.The excess is related to the differences in the character of the heat excitations of the dimers of normal and heavy water,their rotational constants and energy of their vibrational excitations.Significant role is also played by the monomer-dimer and dimer-dimer interactions.
Vansynghel_Ocampo_etal_Proceedings_rev_ESM.docx from Quantifying services and disservices provided by insects and vertebrates in cacao agroforestry landscapes
Creators: name: Vansynghel, Justine
name: Ocampo-Ariza, Carolina
name: Maas, Bea
name: Martin, Emily A.
name: Thomas, Evert
name: Hanf-Dressler, Tara
name: Schumacher, Nils-Christian
name: Ulloque-Samatelo, Carlos
name: Yovera, Fredy F.
name: Tscharntke, Teja
name: Steffan-Dewenter, Ingolf
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Animals provide services such as pollination and pest control in cacao agroforestry systems, but also disservices. Yet, their combined contributions to crop yield and fruit loss are mostly unclear. In a full-factorial field experiment in northwestern Peru, we excluded flying insects, ants, birds and bats from cacao trees and assessed several productivity indicators. We quantified the contribution of each group to fruit set, fruit loss and marketable yield and evaluated how forest distance and canopy closure affected productivity. Fruit set dropped (from 1.7% to 0.3%) when flying insects were excluded and tripled at intermediate (40%) compared to high (greater than 80%) canopy cover in the non-exclusion treatment. Fruit set also dropped with bird and bat exclusion, potentially due to increased abundances of arthropods preying on pollinators or flower herbivores. Overall, cacao yields more than doubled when birds and bats had access to trees. Ants were generally associated with fruit loss, but also with yield increases in agroforests close to forest. We also evidenced disservices generated by squirrels, leading to significant fruit losses. Our findings show that several functional groups contribute to high cacao yield, while trade-offs between services and disservices need to be integrated in local and landscape-scale sustainable cacao agroforestry management.
Temporal evolution of chromospheric evaporation: case studies of the M1.1 flare on 2014 September 6 and X1.6 flare on 2014 September 10
Creators: name: Tian, Hui
name: Young, Peter R.
name: Reeves, Katharine K.
name: Chen, Bin
name: Liu, Wei
name: McKillop, Sean
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: With observations from the Interface Region Imaging Spectrograph (IRIS), we track the complete evolution of $\sim$11 MK evaporation flows in an M1.1 flare on 2014 September 6 and an X1.6 flare on 2014 September 10. These hot flows, as indicated by the blueshifted Fe~{\sc{xxi}}~1354.08Å~line, evolve smoothly with a velocity decreasing exponentially from $\sim$200~km~s$^{-1}$ to almost stationary within a few minutes. We find a good correlation between the flow velocity and energy deposition rate as represented by the hard X-Ray flux observed with the Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI), or time derivative of the soft X-Ray flux observed with the Geostationary Operational Environmental Satellites (GOES) and the HINODE X-ray Telescope (XRT), which is in general agreement with models of nonthermal electron heating. The maximum blue shift of Fe~{\sc{xxi}}~appears approximately at the same time as or slightly after the impulsive enhancement of the ultraviolet continuum and the Mg~{\sc{ii}}~2798.8Å~line emission, demonstrating that the evaporation flow is closely related to heating of the lower chromosphere. Finally, while the hot Fe~{\sc{xxi}}~1354.08Å line is entirely blueshifted with no obvious rest component, cool chromospheric and transition region lines like Si~{\sc{iv}}~1402.77Å are often not entirely redshifted but just reveal an obvious red wing enhancement at the ribbons, suggesting that the speed of chromospheric condensation might be larger than previously thought.
description: 14 figures, ApJ
Spatially-controlled complex molecules and their applications
Creators: name: Chang, Yuan-Pin
name: Horke, Daniel A.
name: Trippel, Sebastian
name: Küpper, Jochen
Publisher: name: arXiv
Year: 2015
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Atomic and Molecular Clusters (physics.atm-clus)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The understanding of molecular structure and function is at the very heart of the chemical and molecular sciences. Experiments that allow for the creation of structurally pure samples and the investigation of their molecular dynamics and chemical function have developed tremendously over the last few decades, although "there's plenty of room at the bottom" for better control as well as further applications. Here, we describe the use of inhomogeneous electric fields for the manipulation of neutral molecules in the gas-phase, \ie, for the separation of complex molecules according to size, structural isomer, and quantum state. For these complex molecules, all quantum states are strong-field seeking, requiring dynamic fields for their confinement. Current applications of these controlled samples are summarised and interesting future applications discussed.
description: Accepted by Int. Rev. Phys. Chem
Worked example and supplementary figures from Quantitative characterization of iridescent colours in biological studies: a novel method using optical theory.
Creators: name: Gruson, Hugo
name: Andraud, Christine
name: WillyDaney DeMarcillac
name: Berthier, Serge
name: Elias, Marianne
name: Gomez, Doris
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Biophysics
subject: Environmental Science
subject: 90301 Biomaterials
subject: FOS: Medical engineering

description: Detailed walkthrough of the method presented in the article on a worked example and multiple supplementary figures that show the variation ranges and correlations of the variables, as well as some numerical illustration of the approximations used in the article.
Regulation of Synaptophysin Degradation by Mammalian Homologues of Seven in Absentia
Creators: name: Chin, Lih Shen
name: Li, An
name: Wheeler, Tiffany C.
name: Roudabush, Francine L.
name: Li, Yankun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Synaptophysin is an integral membrane protein of synaptic vesicles characterized by four transmembrane domains with both termini facing the cytoplasm. Although synaptophysin has been implicated in neurotransmitter release, and decreased synaptophysin levels have been associated with several neurodegenerative diseases, the molecular mechanism that regulates the degradation of synaptophysin remains unsolved. Using the cytoplasmic C terminus of synaptophysin as bait in a yeast two-hybrid screen, we identified two synaptophysin-binding proteins, Siah-1A and Siah-2, which are rat homologues of Drosophila Seven in Absentia. We demonstrated that Siah-1A and Siah-2 associate with synaptophysin both in vitro and in vivo and defined the binding domains of synaptophysin and Siah that mediate their association. Siah proteins exist in both cytosolic and membrane-associated pools and co-localize with synaptophysin on synaptic vesicles and early endosomes. In addition, Siah proteins interact specifically with the brain-enriched E2 ubiquitin-conjugating enzyme UbcH8 and facilitate the ubiquitination of synaptophysin. Furthermore, overexpression of Siah proteins promotes the degradation of synaptophysin via the ubiquitin-proteasome pathway. Our findings indicate that Siah proteins function as E3 ubiquitin-protein ligases to regulate the ubiquitination and degradation of synaptophysin.