cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Strain specific differences in vitamin D3 response: impact on gut homeostasis
Creators: name: Schreiber, Laura
name: Ghimire, Sakhila
name: Hiergeist, Andreas
name: Renner, Kathrin
name: Althammer, Michael
name: Babl, Nathalie
name: Peuker, Alice
name: Schoenhammer, Gabriele
name: Hippe, Katrin
name: Gessner, Andre
name: Albrecht, Christian
name: Pielmeier, Fransziska
name: Büttner-Herold, Maike
name: Bruns, Heiko
name: Hoffmann, Petra
name: Herr, Wolfgang
name: Holler, Ernst
name: Peter, Katrin
name: Kreutz, Marina
name: Matos, Carina
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: vitamin D3, barrier function, intestinal, C57BL/6, BALB/c
subject: 610 Medizin

description: Vitamin D3 regulates a variety of biological processes irrespective of its well-known importance for calcium metabolism. Epidemiological and animal studies indicate a role in immune regulation, intestinal barrier function and microbiome diversity. Here, we analyzed the impact of different vitamin D3- containing diets on C57BL/6 and BALB/c mice, with a particular focus on gut homeostasis and also investigated effects on immune cells in vitro. Weak regulatory effects were detected on murine T cells. By trend, the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 suppressed IFN, GM-CSF and IL-10 cytokine secretion in T cells of C57BL/6 but not BALB/c mice, respectively. Using different vitamin D3-fortified diets, we found a tissue–specific enrichment of mainly CD11b+ myeloid cells but not T cells in both mouse strains e.g. in spleen and Peyer’s Patches. Mucin Reg3γ and Batf expression, as well as important proteins for gut homeostasis, were significantly suppressed in the small intestine of C57BL76 but not BALB/c mice fed with a high-vitamin D3 containing diet. Differences between both mouse stains were not completely explained by differences in vitamin D3 receptor expression which was strongly expressed in epithelial cells of both strains. Finally, we analyzed gut microbiome and again an impact of vitamin D3 was detected in C57BL76 but not BALB/c. Our data suggest strain-specific differences in vitamin D3 responsiveness under steady state conditions which may have important implications when choosing a murine disease model to study vitamin D3 effects.
Juliomys rimofrons Oliveira and Bonvicino 2002
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Juliomys
Juliomys rimofrons

description: Juliomys rimofrons Oliveira and Bonvicino 2002
Juliomys rimofrons Oliveira and Bonvicino 2002, Acta Theriol., 47 (3): 310.
Type Locality: Brazil, Minas Gerais State, Itamonte Municipality, Serra da Mantiqueira, east of Pedra Furada, Brejo da Lapa, 2000 m; 22º21′S, 44º44′W.
Vernacular Names: Cleft-headed Juliomys.
Distribution: Known only from the type locality, SE Brazil.
Discussion: Similar to J. pictipes, but J. rimofrons possesses longer pelage, fewer chromosomes (2n = 20, FN = 34), and a carotid arterial circulation with a supraorbital branch (Oliveira and Bonvicino, 2002).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1121, DOI: 10.5281/zenodo.7316535
Blaptica dubia
Creators: name: Herhold, Hollister W
name: Davis, Steven R
name: Degrey, Samuel P
name: Grimaldi, David A
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Blattodea
Blaberidae
Blaptica
Blaptica dubia

description: Blaptica dubia
“Argentinian wood roach”
Figures 111 (lateral), 112 (dorsal), 113 (ventral)
Plates 67 (lateral), 68 (dorsal), 69 (ventral)
The tracheal architecture of B. dubia features wide, bandlike tra- cheae and numerous visceral branches throughout the body; pre- liminary results indicate that tra- cheae may comprise nearly 12% of the volume of the insect (Herhold et al., in prep.). Spiracles and a handful of major tracheae are labeled in the figures and plates; readers are encouraged to view the 3D models provided in the supplementary digi- tal data for further investigation.
description: Published as part of Herhold, Hollister W, Davis, Steven R, Degrey, Samuel P & Grimaldi, David A, 2023, COMPARATIVE ANATOMY OF THE INSECT TRACHEAL SYSTEM PART 1: INTRODUCTION, APTERYGOTES, PALEOPTERA, POLYNEOPTERA, pp. 1-184 in Bulletin of the American Museum of Natural History 459 (1) on pages 1-184, DOI: 10.5531/sd.sp.55, http://zenodo.org/record/7730159
Nociceptive Flexion Reflex Threshold is No Suitable Marker for Diagnosing Opioid-Induced Hyperalgesia
Creators: name: Trübenbacher, Luisa
name: Lindenberg, Nicole
name: Graf, Bernhard
name: Backmund, Markus
name: Unglaub, Wilhelm
name: Lassen, Christoph L.
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: hyperalgesia, analgesics, opioid, substance-related disorders, methadone, buprenorphine
subject: 610 Medizin

description: Background: Opioid induced hyperalgesia (OIH) describes a state of altered pain sensation due to opioid exposure. It often occurs among persons with opioid use disorder receiving substitution therapy.
Methods: The purpose of this study was to find out, whether OIH diagnosis could be facilitated by an objective pain indicating marker: the Nociceptive Flexion Reflex (NFR). Forty persons with opioid use disorder, 20 of them maintained on methadone and 20 treated with buprenorphine, as well as a control group of 20 opioid-free subjects, were examined. It was aimed to find out whether and in which way these opioid agonists alter reflex threshold (NFR-T). A cold-pressor test was performed to investigate the prevalence of OIH. Furthermore, electrical stimulation and electromyography analyzation were used for NFR-T measurement. Subjective pain ratings were evaluated with a numeric rating scale.
Results: Significantly increased sensitivity to cold pressor pain was found in both maintenance groups when compared to their opioid-free counterparts (p < 0.001). Neither methadone nor buprenorphine showed any effect on NFR-T. This might be explained by the reflex approaching at the wrong location in the central nervous system. Consequently, NFR-T is not a suitable marker for diagnosing OIH.
Conclusion: Although methadone and buprenorphine have been proven to cause OIH, no effect on NFR-T was observed. A statistically significant effect could have been observed with a larger number of participants. Further research, with special focus on patients’ adjuvant medication, should be conducted in the future, to facilitate diagnosis of OIH and provide appropriate pain management for maintenance patients.
Juscelinomys Moojen 1965
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Juscelinomys

description: Juscelinomys Moojen 1965
Juscelinomys Moojen 1965, Rev. Brasil. Biol., 25: 281.
Type Species: Juscelinomys candango Moojen 1965
Species and subspecies: 3 species:
Species Juscelinomys candango Moojen 1965
Species Juscelinomys guaporensis Emmons 1999
Species Juscelinomys huanchacae Emmons 1999
Discussion: Akodontini. Reig (1987:36) viewed Juscelinomys as "an akodontine closely related to Oxymycterus and Lenoxus," an assessment consistent with initial parsimony analyses using cytochrome b data (Emmons, 1999 b). In evaluations of cytochrome b and IRBP sequences, Juscelinomys is portrayed as sister genus to Oxymycterus and more distantly related to Lenoxus (D’Elía, 2003). Morphological discrimination from Oxymycterus and Brucepattersonius amplified by Emmons (1999 b). Collection of additional series is necessary to corroborate the distinction of the described species and to amplify their distributions.
Moojen (1965) provisionally referred Winge’s (1887) Oxymycterus talpinus to Juscelinomys. Langguth (in Fonseca et al., 1996) commented that the form, known to date only as a subfossil, should not be acknowledged as a recent species (e.g., Musser and Carleton, 1993), but in view of the rediscoveries of other species described first as fossils from the Lagoa Santa deposits (e.g.: Bibimys labiosus, Blarinomys breviceps, Lundomys molitor, Pseudoryzomys simplex) or those named subfossils listed as synonyms of living species (e.g.: principalis of Kunsia tomentosus, coronatus of Oryzomys russatus), such a conclusion may be premature (also see Voss and Myers, 1991). In any case, the possible status of talpinus as senior synonym for other Juscelinomys taxa should await critical comparisons and analyses of the type and all known specimens.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1121, DOI: 10.5281/zenodo.7316535
The Triple Adipose-Derived Stem Cell Exosome Technology as a Potential Tool for Treating Triple-Negative Breast Cancer
Creators: name: Pagani, Andrea
name: Duscher, Dominik
name: Geis, Sebastian
name: Klein, Silvan
name: Knoedler, Leonard
name: Panayi, Adriana C.
name: Oliinyk, Dmytro
name: Felthaus, Oliver
name: Prantl, Lukas
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: extracellular vesicles; exosomes; adipose-derived stem cells; tumor microenvironment; triple-negative breast cancer; T.A.E. technology
subject: 610 Medizin

description: Background: Extracellular vesicles are pivotal mediators in intercellular communication, facilitating the exchange of biological information among healthy, pathological and tumor cells. Between the diverse subtypes of extracellular vesicles, exosomes have unique properties and clinical and therapeutical applications. Breast cancer ranks as one of the most prevalent malignancies across the globe. Both the tumor core and its surrounding microenvironment engage in a complex, orchestrated interaction that facilitates cancer’s growth and spread. Methods: The most significant PubMed literature about extracellular vesicles and Adipose-Derived Stem Cell Exosomes and breast cancer was selected in order to report their biological properties and potential applications, in particular in treating triple-negative breast cancer. Results: Adipose-Derived Stem Cell Exosomes represent a potential tool in targeting triple-negative breast cancer cells at three main levels: the tumor core, the tumor microenvironment and surrounding tissues, including metastases. Conclusions: The possibility of impacting triple-negative breast cancer cells with engineered Adipose-Derived Stem Cell Exosomes is real. The opportunity to translate our current in vitro analyses into a future in vivo scenario is even more challenging.
Therapist versus Machine—Immediate Effects of Manual versus Mechanical Lymphatic Drainage in Patients with Secondary Lymphedema
Creators: name: Schiltz, Daniel
name: Eibl, Dominik
name: Mueller, Karolina
name: Biermann, Niklas
name: Prantl, Lukas
name: Taeger, Christian Dirk
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: lymphatic drainage; intermittent pneumatic compression; manual lymphatic drainage; lymphedema; lipedema
subject: 610 Medizin

description: Background: Complex decongestive therapy (CDT) is the standard and basic therapy for lymphedema. The central component of CDT is manual lymphatic drainage (MLD). In addition to CDT, other measures such as intermittent pneumatic compression therapy (IPCT) (active compression machine therapy) are available. In this prospective research study, the objective and subjective effects of MLD and IPCT on lymphedema of the lower extremity were investigated and both therapies were directly compared. Furthermore, the patients’ body mass index (BMI) and stage of lymphedema were tested for their effect on the respective therapy. Methods: Patients participating in the study received both therapies (MLD and IPCT) on the same lymphedema-affected limb at an interval of two days. The objective volumetric therapy effect was measured by the digital volume measurement of the affected limb. The subjective effects of the therapies were measured using two specially designed questionnaires. Results: A total of 40 patients were included in the study. There was no significant difference in the volume differences between the interventions, BMI categories, lymphedema, or treatment order regarding the immediate and two-day effect. Conclusions: No significant difference was found in the subjective or objective therapy efficacy of the two methods. Intermittent pneumatic compression therapy is considered a comparable therapeutic procedure when properly indicated.
Neurofilament Light Chain Concentration in Cerebrospinal Fluid in Children with Acute Nontraumatic Neurological Disorders
Creators: name: Geis, Tobias
name: Gutzeit, Svena
name: Disse, Sigrid
name: Kuhle, Jens
name: Fouzas, Sotirios
name: Wellmann, Sven
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: neurofilament light chain NfL; biomarker; meningitis; Bell’s facial palsy; Lyme neuroborreliosis LNB; child
subject: 610 Medizin

description: (1) Introduction: This pilot study aimed to analyze neurofilament light chain levels in cerebrospinal fluid (cNfL) in a cohort of children with different acute nontraumatic neurological conditions. (2) Methods: This prospective observational cohort study consisted of 35 children aged 3 months to 17 years and was performed from November 2017 to December 2019. Patients’ clinical data were reviewed, and patients were assigned to the following groups: n = 10 (28.6%) meningitis, 5 (14.3%) Bell’s palsy, 7 (20.0%) febrile non-CNS infection, 3 (8.6%) complex febrile seizure, 4 (11.4%) idiopathic intracranial hypertension, and 6 (17.1%) others. cNfL levels were measured using a sensitive single-molecule array assay. (3) Results: The cNfL levels [median (range)] in children with meningitis were 120.5 pg/mL (58.1–205.4), in Bell’s palsy 88.6 pg/mL (48.8–144.5), in febrile non-CNS infection 103.9 pg/mL (60.1–210.8), in complex febrile seizure 56 pg/mL (53.2–58.3), and in idiopathic intracranial hypertension 97.1 pg/mL (60.1–124.6). Within the meningitis group, children with Lyme neuroborreliosis (LNB) had significantly higher cNfL concentrations (median 147.9 pg/mL; range 87.8–205.4 pg/mL) than children with enterovirus meningitis (72.5 pg/mL; 58.1–95.6 pg/mL; p = 0.048) and non-significantly higher cNfL levels when compared to Bell’s palsy (88.6 pg/mL; 48.8–144.5 pg/mL; p = 0.082). There was no correlation between cNfL levels and age. (4) Conclusions: Although the number of patients in this pilot study cohort is limited, higher cNfL levels in children with LNB compared to those with viral meningitis (significant) and Bell’s palsy (trend) may indicate the potential of cNfL as a biomarker in the differential diagnosis of pediatric meningitis and facial palsy.
Gromphadorinha portentosa
Creators: name: Herhold, Hollister W
name: Davis, Steven R
name: Degrey, Samuel P
name: Grimaldi, David A
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Phasmida
Diapheromeridae
Gromphadorinha
Gromphadorinha portentosa

description: Gromphadorhina portentosa
“Madagascar hissing cockroach”
Figures 114 (lateral), 115 (dorsal), 116 (ventral)
Plates 70 (lateral), 71 (dorsal), 72 (ventral)
Easily the most popular cock- roach (as far as cockroach popular- ity goes), the physiology of the hissing behavior of G. portentosa was investigated by Nelson and col- leagues (Nelson, 1979; Nelson and Fraser, 1980), with the notable find- ing that the fourth spiracle (A2-S) is the source of the hiss. Heinrich et al. (2013) documented unidirectional airflow in G. portentosa resulting from spiracular valve control. As seen in the plates, the tracheal archi- tecture of Gromphadorhina is remarkably complex, so only spiracles and major tracheae are labeled here. As is common in reared Gromphadorhina colonies, the individual scanned was infested with mites (see fig. 117), likely Gromphadorholaelaps schaeferi, found to be possibly beneficial by Yoder et al. (2012).
description: Published as part of Herhold, Hollister W, Davis, Steven R, Degrey, Samuel P & Grimaldi, David A, 2023, COMPARATIVE ANATOMY OF THE INSECT TRACHEAL SYSTEM PART 1: INTRODUCTION, APTERYGOTES, PALEOPTERA, POLYNEOPTERA, pp. 1-184 in Bulletin of the American Museum of Natural History 459 (1) on pages 1-184, DOI: 10.5531/sd.sp.55, http://zenodo.org/record/7730159
title: Activité du port de Saint-Malo – 1761 – Saint-Sébastien
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: matériaux de construction

description: Cette fiche est issue de l’enquête menée par Jean Delumeau sur l’activité du port de Saint-Malo au 17e et 18e siècle. Cette fiche correspond à l’activité de l’année 1761 avec le port "Saint-Sébastien"
description: Marchandises arrivées à Saint-Malo : résine
description: Catégories de marchandises arrivées à Saint-Malo : matériaux de construction
description: Coverage: Grand commerce
description: Bibliographic citation: LE POEZAT-GUIGNER, Annie. Les Activités du port de Saint-Malo en 1761. DES : Histoire : Rennes : 1967 (Bibliothèque François-Lebrun, MH 1050)
description: date: Date de numérisation : 2021 à 2023
description: created: Années 1950-1960
Additional file 3 of Subcutaneous inoculation of Escherichia coli in broiler chickens causes cellulitis and elicits innate and specific immune responses
Creators: name: Jonare, Liv
name: Wattrang, Eva
name: Östlund, Emma
name: Wall, Helena
name: Jacobson, Magdalena
name: Jansson, Désirée S.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Additional file 3. Gating strategy for E. coli adherence to leukocyte populations. Gating strategy for flow cytometric analysis of E. coli adhered to heterophils, monocytes and thrombocytes, respectively, after incubation in vitro in whole blood cultures using panel 3 (Table 1). Identification of E. coli adhered to heterophils, monocytes, and thrombocytes, through singlet gating, FSC/SSC characteristics and using CD45-PerCp/Cy5.5, CD41/61-Fitc, KUL01-PE (MRC1L-B) and FarRed labelled E. coli . From the initial dot-plot in A singlet gating (FSC-H vs FSC-A) was performed in B. From the singlet gate in B CD45 high and CD45 intermediate/SSC low events were gated in C. From the gate in C the SSC high events were gated in D and from this gate CD45 high/PE low events were gated in E and back-gated as heterophils (high SSC) in F. Heterophils positive for adhered E. coli were defined in G, in G1 a control culture without bacteria is shown and in G2 a culture incubated with E. coli is shown. From the gate in C, thrombocytes (CD41/61 positive) and KUL01 positive events were gated in H. Thrombocytes positive for adhered E. coli were defined in I, in I1 a control culture without bacteria is shown and in I2 a culture incubated with E. coli is shown. From the KUL01 gate in H events were gated as monocytes based on FSC/SSC characteristics in J. Monocytes positive for adhered E. coli were defined in K, in K1 a control culture without bacteria is shown and in K2 a culture incubated with E. coli is shown. A representative whole blood culture from a chicken from group B (no. 38) on day 7 is shown with FarRed labelled E. coli of strain ECB11
title: A universal variational framework for parabolic equations and systems
Creators: name: Auscher, Pascal
name: Egert, Moritz
Publisher: name: Springer
Year: 2025

description: We propose a variational approach to solve Cauchy problems for parabolic equations and systems independently of regularity theory for solutions. This produces a universal and conceptually simple construction of fundamental solution operators (also called propagators) for which we prove L² off-diagonal estimates, which is new under our assumptions. In the special case of systems for which pointwise local bounds hold for weak solutions, this provides Gaussian upper bounds for the corresponding fundamental solution. In particular, we obtain a new proof of Aronson’s estimates for real equations. The scheme is general enough to allow systems with higher order elliptic parts on full space or second order elliptic parts on Sobolev spaces with boundary conditions. Another new feature is that the control on lower order coefficients is within critical mixed time-space Lebesgue spaces or even mixed Lorentz spaces.
Isoptera Brulle 1832
Creators: name: Herhold, Hollister W
name: Davis, Steven R
name: Degrey, Samuel P
name: Grimaldi, David A
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia

description: INFRAORDER ISOPTERA
Although the respiratory physiology of termites (especially as it relates to their digestive system) has been studied for decades, micro-CT scans of respiratory architectures have been absent. The tracheal scans of the reproductive caste Reticulatermes flavipes and soldier caster Zootermopsis angusticollis shown here detail the remarkable intricacy of tracheal branches, especially in the abdomen, well known for its adaptations for digesting cellulose. Although both specimens were scanned at approximately 5 µm resolution, the worker Reticulitermes possesses notably smaller tracheae than the soldier Zootermopsis. Although the two specimens feature many similarities, notably a T1-DLT prothoracic “loop,” the differences are sufficient to describe both in detail.
Wing-leg branching patterns, referred to here as Chapman’s Triangle (see Discussion section), are evident in both termites, albeit with some minor modifications (Chapman, 1918). In Zootermopsis, T2-AWL branches from T2-DB rather than directly from T2-S (as in Dermaptera and others), T3-AWL is off T3-S. In Reticulitermes, T2-VL branches from T2-VB, rather than T2-VLT, and T3-VL branches off T3-VB. (These could be Tn-Cx and not Tn-VL.)
description: Published as part of Herhold, Hollister W, Davis, Steven R, Degrey, Samuel P & Grimaldi, David A, 2023, COMPARATIVE ANATOMY OF THE INSECT TRACHEAL SYSTEM PART 1: INTRODUCTION, APTERYGOTES, PALEOPTERA, POLYNEOPTERA, pp. 1-184 in Bulletin of the American Museum of Natural History 459 (1) on pages 1-184, DOI: 10.5531/sd.sp.55, http://zenodo.org/record/7730159
Immune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions
Creators: name: Knoedler, Leonard
name: Dean, Jillian
name: Diatta, Fortunay
name: Thompson, Noelle
name: Knoedler, Samuel
name: Rhys, Richmond
name: Sherwani, Khalil
name: Ettl, Tobias
name: Mayer, Simon
name: Falkner, Florian
name: Kilian, Katja
name: Panayi, Adriana C.
name: Iske, Jasper
name: Safi, Ali-Farid
name: Tullius, Stefan G.
name: Haykal, Siba
name: Pomahac, Bohdan
name: Kauke-Navarro, Martin
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: solid organ transplantation, SOT, vascularized composite allotransplantation, VCA, cellular therapies
subject: 610 Medizin

description: Balancing the immune response after solid organ transplantation (SOT) and vascularized composite allotransplantation (VCA) remains an ongoing clinical challenge. While immunosuppressants can effectively reduce acute rejection rates following transplant surgery, some patients still experience recurrent acute rejection episodes, which in turn may progress to chronic rejection. Furthermore, these immunosuppressive regimens are associated with an increased risk of malignancies and metabolic disorders. Despite significant advancements in the field, these IS related side effects persist as clinical hurdles, emphasizing the need for innovative therapeutic strategies to improve transplant survival and longevity. Cellular therapy, a novel therapeutic approach, has emerged as a potential pathway to promote immune tolerance while minimizing systemic side-effects of standard IS regiments. Various cell types, including chimeric antigen receptor T cells (CAR-T), mesenchymal stromal cells (MSCs), regulatory myeloid cells (RMCs) and regulatory T cells (Tregs), offer unique immunomodulatory properties that may help achieve improved outcomes in transplant patients. This review aims to elucidate the role of cellular therapies, particularly MSCs, T cells, Tregs, RMCs, macrophages, and dendritic cells in SOT and VCA. We explore the immunological features of each cell type, their capacity for immune regulation, and the prospective advantages and obstacles linked to their application in transplant patients. An in-depth outline of the current state of the technology may help SOT and VCA providers refine their perioperative treatment strategies while laying the foundation for further trials that investigate cellular therapeutics in transplantation surgery.
title: Activité du port de Saint-Malo – 1723 – Grand Banc de Terre-Neuve
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: produits de la mer
subject: épices et condiments

description: Marchandises au départ de Saint-Malo : sel
description: Catégories de marchandises au départ de Saint-Malo : produits de la mer ; épices et condiments
description: Cette fiche est issue de l’enquête menée par Jean Delumeau sur l’activité du port de Saint-Malo au 17e et 18e siècle. Cette fiche correspond à l’activité de l’année 1723 avec le port "Grand Banc"
description: Coverage: Grand commerce
description: Bibliographic citation: HALL, François. Le Commerce maritime de Saint-Malo en 1723 et 1724. DES : Histoire : Rennes, 1964 (Bibliothèque François-Lebrun, MH 1024)
description: date: Date de numérisation : 2021 à 2023
description: created: Années 1950-1960
Juscelinomys candango Moojen 1965
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Juscelinomys
Juscelinomys candango

description: Juscelinomys candango Moojen 1965
Juscelinomys candango Moojen 1965, Rev. Brasil. Biol., 25: 281.
Type Locality: Brazil, Federal District, Brasília, Parque Zoobotanico, 1030 m.
Vernacular Names: Candango Akodont.
Distribution: C Brazil.
Conservation: IUCN – Lower Risk (nt).
Discussion: Morphology of type series amplified by Emmons (1999 b) and compared with two new species (see next accounts).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1121, DOI: 10.5281/zenodo.7316535
Additional file 1 of Integration of psychological interventions in multi-sectoral humanitarian programmes: a systematic review
Creators: name: Ndlovu, Jacqueline N.
name: Lind, Jonna
name: Patlán, Andrés Barrera
name: Upadhaya, Nawaraj
name: Leku, Marx R.
name: Akellot, Josephine
name: Skovdal, Morten
name: Augustinavicius, Jura L.
name: Tol, Wietse A.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Supplementary Material 1.
title: Lettre n°189 de Paul d'Estournelles de Constant à Nicholas Murray Butler (22 novembre 1916)
title: Letter number 189 from Paul d'Estournelles de Constant to Nicholas Murray Butler (November 22, 1916)
Creators: name: d'Estournelles de Constant, Paul
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: Pacifisme
Guerre mondiale (1914-1918)

description: Source: Archives de la Sarthe – France
Juscelinomys guaporensis Emmons 1999
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Juscelinomys
Juscelinomys guaporensis

description: Juscelinomys guaporensis Emmons 1999
Juscelinomys guaporensis Emmons 1999, Am. Mus. Novit., 3280: 4.
Type Locality: Bolivia, Santa Cruz Dept., Velasco Prov., Parque Nacional Noel Kempff Mercado, Flor de Oro, 210 m; 13º33.10′S, 61º00.51′W.
Vernacular Names: Guapore Akodont.
Distribution: Known only from the type locality.
Discussion: The type and single known specimen is cranially similar to J. candango but smaller and has different colored pelage.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1122, DOI: 10.5281/zenodo.7316535
Relationship between interprofessional collaboration and psychological distress experienced by healthcare professionals during COVID-19: a monocentric cross-sectional study
Creators: name: Ruttmann, Kirstin
name: Albaladejo-Fuertes, Sheila
name: Lindenberg, Nicole
name: Kunst, Claudia
name: Mehrl, Alexander
name: Kindl, Vera
name: Gülow, Karsten
name: Schlosser-Hupf, Sophie
name: Schmid, Stephan
name: Müller, Martina
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: interprofessional collaboration, interprofessional communication, interprofessional education, COVID-19 pandemic, mental well-being of healthcare professionals, mental health of health professionals, interprofessional collaborative practice, internal medicine
subject: 610 Medizin

description: Background: Since the onset of the COVID-19 pandemic, global healthcare systems have faced unprecedented challenges, leading to significant psychological distress among healthcare professionals. Recognizing the importance of enhanced interprofessional collaboration in alleviating this burden, as emphasized by the World Health Organization in 2020, we investigated whether such collaboration could mitigate staff psychological distress during crises. To our knowledge, no study has yet explored the role of interprofessional collaboration as a resilience factor in crises.

Methods: For this monocentric cross-sectional study at a German university hospital, we examined the relationship between the quality of interprofessional collaboration and the psychological distress of healthcare professionals during the initial pandemic wave. We employed validated mental health instruments, such as the GAD-7 and PHQ-2, to assess anxiety and depressive symptoms. Additionally, custom-designed questionnaires evaluated “Pandemic-Associated Burden and Anxiety (PAB; PAA)” and interprofessional crisis management experiences. A novel “Interprofessional collaboration and communication (IPC)” assessment tool was developed based on international competency frameworks, demonstrating strong reliability.

Results: The study involved 299 healthcare professionals (78.6% in direct contact with COVID-19 patients). Moderate levels of PAB/PAA were reported. However, a significant proportion experienced clinically relevant anxiety, as indicated by GAD-7. Negative IPC perceptions correlated with higher levels of psychological distress. Linear regression analysis showed associations between interprofessional collaboration and anxious and depressive symptoms, and pandemic-related burden.

Conclusion: Our findings highlight the vital role of enhanced interprofessional collaboration in strengthening the psychological well-being of healthcare professionals during crises. The study underscores the need to foster a collaborative environment and integrate interprofessional education for resilience.
title: Activité du port de Saint-Malo – 1714 – Cancale
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: produits agroalimentaires
subject: céréales
subject: matériaux de construction
subject: produits combustibles

description: Cette fiche est issue de l’enquête menée par Jean Delumeau sur l’activité du port de Saint-Malo au 17e et 18e siècle. Cette fiche correspond à l’activité de l’année 1714 avec le port "Cancale"
description: Marchandises arrivées à Saint-Malo : froment ; bois ; bois à construire ; bois à feu
description: Catégories de marchandises arrivées à Saint-Malo : produits agroalimentaires ; céréales ; matériaux de construction ; produits combustibles
description: Coverage: Petit cabotage
description: Bibliographic citation: BOSSARD, Joseph. Le Trafic malouin en 1714 et 1715. DES : Histoire : Rennes, 1964 (Bibliothèque François-Lebrun, MH 1020)
description: date: Date de numérisation : 2021 à 2023
description: created: Années 1950-1960
Time to Positivity in Blood Culture Bottles Inoculated with Sonication Fluid from Fracture-Related Infections
Creators: name: Henssler, Leopold
name: Schellenberger, Lena
name: Baertl, Susanne
name: Klute, Lisa
name: Heyd, Robert
name: Kerschbaum, Maximilian
name: Alt, Volker
name: Popp, Daniel
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: sonication; fracture-related infections; time to positivity; microbiology; diagnostics; antibiotic stewardship; bacteria
subject: 610 Medizin

description: The timely and accurate identification of causative agents is crucial for effectively managing fracture-related infections (FRIs). Among various diagnostic methods, the “time to positivity” (TTP) of cultures has emerged as a valuable predictive factor in infectious diseases. While sonication of implants and inoculation of blood culture bottles with sonication fluid have enhanced sensitivity, data on the TTP of this microbiological technique remain limited. Therefore, patients with ICM criteria for confirmed FRI treated at our institution between March 2019 and March 2023 were retrospectively identified and their microbiological records were analyzed. The primary outcome parameter was TTP for different microorganism species cultured in a liquid culture collected from patients with confirmed FRI. A total of 155 sonication fluid samples from 126 patients (average age 57.0 ± 17.4 years, 68.3% males) was analyzed. Positive bacterial detection was observed in 78.7% (122/155) of the liquid culture pairs infused with sonication fluid. Staphylococcus aureus was the most prevalent organism (42.6%). Streptococcus species exhibited the fastest TTP (median 11.9 h), followed by Staphylococcus aureus (median 12.1 h) and Gram-negative bacteria (median 12.5 h), all of which had a 100% detection rate within 48 h after inoculation. Since all Gram-negative pathogens yielded positive culture results within 24 h, it could be discussed if empirical antibiotic therapy could be de-escalated early and limited towards the Gram-positive germ spectrum if no Gram-negative pathogens are detected up to this time point in the context of antibiotic stewardship.
Legaut, Marcel und Varillon, Francois: Zwei Christen auf dem Weg
Creators: name: Jockwig, Klemens
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 24 (1983): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 24
Juscelinomys huanchacae Emmons 1999
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Juscelinomys
Juscelinomys huanchacae

description: Juscelinomys huanchacae Emmons 1999
Juscelinomys huanchacae Emmons 1999, Am. Mus. Novit., 3280: 2.
Type Locality: Bolivia, Santa Cruz Dept., Velasco Prov., Serrania de Huanchaca, Parque Nacional Noel Kempff Mercado, Campamento "Huanchaca II," 700 m; 14º31.42′S, 60º44.37′W.
Vernacular Names: Huanchaca Akodont.
Distribution: Known only from the type locality.
Discussion: The type and single known specimen is the largest individual recorded for the genus.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1122, DOI: 10.5281/zenodo.7316535
Reuss, Josef M.: In der Sorge um die Priester und das ganze Gottesvolk
Creators: name: Lippert, Peter
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 24 (1983): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 24
title: Lettre n°551 de Paul d'Estournelles de Constant à Nicholas Murray Butler (27 juin 1919)
title: Letter number 551 from Paul d'Estournelles de Constant to Nicholas Murray Butler (June 27, 1919)
Creators: name: d'Estournelles de Constant, Paul
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: Pacifisme
Guerre mondiale (1914-1918)

description: Source: Archives de la Sarthe – France
Kunsia Hershkovitz 1966
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Kunsia

description: Kunsia Hershkovitz 1966
Kunsia Hershkovitz 1966, Z. Saugetierk., 31 (2): 112.
Type Species: Mus tomentosus Lichtenstein 1830
Species and subspecies: 2 species:
Species Kunsia fronto (Winge 1887)
Species Kunsia tomentosus (Lichtenstein 1830)
Discussion: Akodontini. Species formerly included in Scapteromys until set apart in Kunsia by Hershkovitz (1966 c), who arranged both genera in the "scapteromyine group," which he viewed as closely related to oxymycterines. Formal tribal segregation of the two genera, later including Bibimys, advanced by Massoia (1979 b) and Reig (1980, 1981). Although the probable sister genus of Scapteromys, parsimony and likelihood analyses of cytochrome b data represent the two as nested within the akodontine radiation and distantly related to Bibimys (D’Elía et al., 2003; Smith and Patton, 1999). D’Elía (2003) identified the pair Kunsia Scapteromys as one of five major clades within Akodontini. Karyology summarized by Gardner and Patton (1976). Confirmation of species limits, junior synonyms, and geographic ranges overdue.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1122, DOI: 10.5281/zenodo.7316535
Kunsia fronto
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Kunsia
Kunsia fronto

description: Kunsia fronto (Winge 1887)
[Gyldenstolpia] fronto Winge 1887, E Museo Lundii, Vol. 1, 3: 44.
Type Locality: Brazil, Minas Gerais State, Rio das Velhas, Pleistocene cave deposits ("Lapa da Escrivania no. 5") near Lagoa Santa.
Vernacular Names: Fossorial Kunsia.
Synonyms: Kunsia chacoensis (Gyldenstolpe 1932); Kunsia planaltensis Avila-Pires 1972.
Distribution: Isolated localities in NE Argentina, and EC Brazil; range poorly documented.
Conservation: IUCN – Vulnerable.
Discussion: Taxonomy and distribution reviewed by Avila-Pires (1972).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1122, DOI: 10.5281/zenodo.7316535
In-hospital mortality of patients with periprosthetic joint infection
Creators: name: Reinhard, Jan
name: Lang, Siegmund
name: Walter, Nike
name: Schindler, Melanie
name: Bärtl, Susanne
name: Szymski, Dominik
name: Alt, Volker
name: Rupp, Markus
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: Periprosthetic joint infection (PJI); in-hospital mortality; total joint replacement complications; Institute-for-the-Hospital-Remuneration-System-in-Germany (InEK); comorbidities; diagnostic tools; epidemiology; atrial fibrillation; diabetes mellitus; septic shock; anticoagulant therapy; Hypertension; obesity; coronary heart disease
subject: 610 Medizin

description: Aims

Periprosthetic joint infection (PJI) demonstrates the most feared complication after total joint replacement (TJR). The current work analyzes the demographic, comorbidity, and complication profiles of all patients who had in-hospital treatment due to PJI. Furthermore, it aims to evaluate the in-hospital mortality of patients with PJI and analyze possible risk factors in terms of secondary diagnosis, diagnostic procedures, and complications.
Methods

In a retrospective, cross-sectional study design, we gathered all patients with PJI (International Classification of Diseases (ICD)-10 code: T84.5) and resulting in-hospital treatment in Germany between 1 January 2019 and 31 December 2022. Data were provided by the Institute for the Hospital Remuneration System in Germany. Demographic data, in-hospital deaths, need for intensive care therapy, secondary diagnosis, complications, and use of diagnostic instruments were assessed. Odds ratios (ORs) with 95% confidence intervals (CIs) for in-hospital mortality were calculated.
Results

A total of 52,286 patients were included, of whom 1,804 (3.5%) died. Hypertension, diabetes mellitus, and obesity, the most frequent comorbidities, were not associated with higher in-hospital mortality. Cardiac diseases as atrial fibrillation, cardiac pacemaker, or three-vessel coronary heart disease showed the highest risk for in-hospital mortality. Postoperative anaemia occurred in two-thirds of patients and showed an increased in-hospital mortality (OR 1.72; p < 0.001). Severe complications, such as organ failure, systemic inflammatory response syndrome (SIRS), or septic shock syndrome showed by far the highest association with in-hospital mortality (OR 39.20; 95% CI 33.07 to 46.46; p < 0.001).
Conclusion

These findings highlight the menace coming from PJI. It can culminate in multi-organ failure, SIRS, or septic shock syndrome, along with very high rates of in-hospital mortality, thereby highlighting the vulnerability of these patients. Particular attention should be paid to patients with cardiac comorbidities such as atrial fibrillation or three-vessel coronary heart disease. Risk factors should be optimized preoperatively, anticoagulant therapy stopped and restarted on time, and sufficient patient blood management should be emphasized.
title: Lettre n°1054 de Paul d'Estournelles de Constant à Nicholas Murray Butler (6 avril 1922)
title: Letter number 1054 from Paul d'Estournelles de Constant to Nicholas Murray Butler (April 6, 1922)
Creators: name: d'Estournelles de Constant, Paul
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: Pacifisme
Guerre mondiale (1914-1918)

description: Source: Archives de la Sarthe – France
Kunsia tomentosus
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Kunsia
Kunsia tomentosus

description: Kunsia tomentosus (Lichtenstein 1830)
[Mus] tomentosus Lichtenstein 1830, Darst. Saugeth., Vol. 7, 15: 33.
Type Locality: Brazil, SE area along the Río Uruguay (as restricted by Hershkovitz, 1966 c:120).
Vernacular Names: Woolly Kunsia.
Synonyms: Kunsia gnambiquarae (Mirando Ribeiro 1914); Kunsia principalis (Lund 1840).
Distribution: NE Bolivia (Beni and Santa Cruz Depts.—Anderson, 1993, 1997) and WC Brazil (Mato Grosso); Pleistocene cave samples in Minas Gerais, Brazil.
Conservation: IUCN – Vulnerable.
Discussion: Rare in collections; range inadequately known. See Massoia and Fornes (1965) and Hershkovitz (1966 c) for justification of synonymy.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1122, DOI: 10.5281/zenodo.7316535
A data-driven approach for the partial reconstruction of individual human molar teeth using generative deep learning
Creators: name: Broll, Alexander
name: Rosentritt, Martin
name: Schlegl, Thomas
name: Goldhacker, Markus
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: inlay restoration, dental prosthesis design, StyleGAN,machine learning, digital dentistry
subject: 610 Medizin

description: Background and objective: Due to the high prevalence of dental caries, fixed dental restorations are regularly required to restore compromised teeth or replace missing teeth while retaining function and aesthetic appearance. The fabrication of dental restorations, however, remains challenging due to the complexity of the human masticatory system as well as the unique morphology of each individual dentition. Adaptation and reworking are frequently required during the insertion of fixed dental prostheses (FDPs), which increase cost and treatment time. This article proposes a data-driven approach for the partial reconstruction of occlusal surfaces based on a data set that comprises 92 3D mesh files of full dental crown restorations.

Methods: A Generative Adversarial Network (GAN) is considered for the given task in view of its ability to represent extensive data sets in an unsupervised manner with a wide variety of applications. Having demonstrated good capabilities in terms of image quality and training stability, StyleGAN-2 has been chosen as the main network for generating the occlusal surfaces. A 2D projection method is proposed in order to generate 2D representations of the provided 3D tooth data set for integration with the StyleGAN architecture. The reconstruction capabilities of the trained network are demonstrated by means of 4 common inlay types using a Bayesian Image Reconstruction method. This involves pre-processing the data in order to extract the necessary information of the tooth preparations required for the used method as well as the modification of the initial reconstruction loss.

Results: The reconstruction process yields satisfactory visual and quantitative results for all preparations with a root mean square error (RMSE) ranging from 0.02 mm to 0.18 mm. When compared against a clinical procedure for CAD inlay fabrication, the group of dentists preferred the GAN-based restorations for 3 of the total 4 inlay geometries.

Conclusions: This article shows the effectiveness of the StyleGAN architecture with a downstream optimization process for the reconstruction of 4 different inlay geometries. The independence of the reconstruction process and the initial training of the GAN enables the application of the method for arbitrary inlay geometries without time-consuming retraining of the GAN.