cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
EFFECT OF CONCURRENT SUBSTANCE USE DISORDER ON THE EFFECTIVENESS OF SINGLE AND COMBINATION ANTIDEPRESSANT MEDICATIONS FOR THE TREATMENT OF MAJOR DEPRESSION: AN EXPLORATORY ANALYSIS OF A SINGLE-BLIND RANDOMIZED TRIAL: Effect of Concurrent Substance Use Disorder
Creators: name: Gaynes, Bradley N.
name: Zisook, Sidney
name: Wisniewski, Stephen R.
name: Davis, Lori L.
name: Rush, A. John
name: Howland, Robert H.
name: Balasubramani, G.K.
name: Fava, Maurizio
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The co-occurrence of substance use disorder (SUD) and major depressive disorder (MDD) is common and is often thought to impair response to antidepressant therapy. These patients are often excluded from clinical trials, resulting in a significant knowledge gap regarding optimal pharmacotherapy for the treatment of MDD with concurrent SUD.
title: Bisphosphonate-related femoral fractures
Creators: name: Freitas, Hugo
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Bones
subject: Musculoskeletal bone
subject: CT
subject: Digital radiography
subject: Diagnostic procedure
subject: Demineralisation-Bone
subject: Drugs / Reactions
subject: Osteoporosis

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Describe bisphosphonate-related atypical femoral fractures (BRAFF). Define fracture patterns and possible complications. Analyze the clinical significance of early diagnosis and its value for...
High-contrast imaging constraints on gas giant planet formation - The Herbig Ae/Be star opportunity
Creators: name: Quanz, Sascha P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Planet formation studies are often focused on solar-type stars, implicitly considering our Sun as reference point. This approach overlooks, however, that Herbig Ae/Be stars are in some sense much better targets to study planet formation processes empirically, with their disks generally being larger, brighter and simply easier to observe across a large wavelength range. In addition, massive gas giant planets have been found on wide orbits around early type stars, triggering the question if these objects did indeed form there and, if so, by what process. In the following I briefly review what we currently know about the occurrence rate of planets around intermediate mass stars, before discussing recent results from Herbig Ae/Be stars in the context of planet formation. The main emphasis is put on spatially resolved polarized light images of potentially planet forming disks and how these images - in combination with other data - can be used to empirically constrain (parts of) the planet formation process. Of particular interest are two objects, HD100546 and HD169142, where, in addition to intriguing morphological structures in the disks, direct observational evidence for (very) young planets has been reported. I conclude with an outlook, what further progress we can expect in the very near future with the next generation of high-contrast imagers at 8-m class telescopes and their synergies with ALMA.
description: Accepted by Astrophysics and Space Science as invited short review in special issue about Herbig Ae/Be stars; 12 pages incl. 5 figures, 2 tables and references
(400834) William Alexander Mill
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
RAPID RESPONSE TO FLUOXETINE IN WOMEN WITH PREMENSTRUAL DYSPHORIC DISORDER
Creators: name: Schmidt, Peter J.
name: Steinberg, Emma M.
name: Martinez, Pedro E.
name: Rubinow, David R.
name: Cardoso, Graca M.P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Selective serotonin reuptake inhibitors (SRIs) relieve irritability within days in women with premenstrual dysphoric disorder (PMDD); however, the effects on other affective symptoms in PMDD remain to be demonstrated.
Supplementary data from An eutherian intronic sequence gave rise to a major satellite DNA in Platyrrhini
Creators: name: Valeri, Mirela Pelizaro
name: Dias, Guilherme Borges
name: Pereira, Valéria Do Socorro
name: Kuhn, Gustavo Campos Silva
name: Svartman, Marta
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences

description: Supplementary figures and tables
Differential Regulation of CASZ1 Protein Expression During Cardiac and Skeletal Muscle Development
Creators: name: Amin, Nirav M.
name: Gibbs, Devin
name: Conlon, Frank L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: BACKGROUND: The zinc-finger transcription factor CASZ1 is required for differentiation of a distinct population of cardiomyocytes during development. However, expression of Casz1 mRNA is detected throughout the developing heart, suggesting the spatial regulation of CASZ1 occurs at the protein level. Relatively little is known about posttranscriptional regulation of Casz1 in the heart.

RESULTS: We generated antibodies that specifically recognize CASZ1 in developing Xenopus embryos, and performed immunofluorescence analysis of CASZ1 during cardiac development. CASZ1 was detected throughout the developing myocardium. CASZ1 was restricted to terminally differentiated cardiomyocytes, and was down-regulated in cells that re-enter the cell cycle. We determined that CASZ1 expression correlated with terminal differentiation in cardiac muscle cells, skeletal muscle cells, and lymph-heart musculature.

CONCLUSIONS: This study indicates that spatially distinct expression of CASZ1 protein may be due to posttranscriptional control of Casz1 mRNA during cardiac development. The results of this study provide insights into the role of Casz1 in cardiac function and in the differentiation of other cell types, including skeletal muscle and lymph heart.
title: Imaging features of gastrointestinal stromal tumors.
Creators: name: Jelassi, Achref
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Oncology
subject: CT
subject: Diagnostic procedure
subject: Neoplasia

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: To illustrate typical and atypical imaging appearances of...
(400831) Margaret Ann Mill
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Epicardial-derived adrenomedullin drives cardiac hyperplasia during embryogenesis.
Creators: name: Wetzel-Strong, Sarah E.
name: Nishikimi, Toshio
name: Caron, Kathleen M.
name: Klein, Klara R.
name: Li, Manyu
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: BACKGROUND: Growth promoting signals from the epicardium are essential for driving myocardial proliferation during embryogenesis. In adults, these signals become reactivated following injury and promote angiogenesis and myocardial repair. Therefore, identification of such paracrine factors could lead to novel therapeutic strategies. The multi-functional peptide adrenomedullin (Adm 5 gene, AM 5 protein) is required for normal heart development. Moreover, elevated plasma AM following myocardial infarction offers beneficial cardioprotection and serves as a powerful diagnostic and prognostic indication of disease severity.

RESULTS: Here, we developed a new model of Adm overexpression by stabilizing the Adm mRNA through gene-targeted replacement of the endogenous 30 untranslated region. As expected, Admhi/hi mice express three-times more AM than controls in multiple tissues, including the heart. Despite normal blood pressures, Admhi/hi mice unexpectedly showed significantly enlarged hearts due to increased cardiac hyperplasia during development. The targeting vector was designed to allow for reversion to wild-type levels by means of Cre-mediated modification. Using this approach, we demonstrate that AM derived from the epicardium, but not the myocardium or cardiac fibroblast, is responsible for driving cardiomyocyte hyperplasia.

CONCLUSIONS: AM is produced by the epicardium and drives myocyte proliferation during development, thus representing a novel and clinically relevant factor potentially related to mechanisms of cardiac repair after injury.
Quantum dynamics of an electromagnetic mode that cannot contain N photons
Creators: name: Bretheau, Landry
name: Campagne-Ibarcq, Philippe
name: Flurin, Emmanuel
name: Mallet, François
name: Huard, Benjamin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Electromagnetic modes are instrumental in building quantum machines. In this experiment, we introduce a method to manipulate these modes by effectively controlling their phase space. Preventing access to a single energy level, corresponding to a number of photons N, confined the dynamics of the field to levels 0 to N-1. Under a resonant drive, the level occupation was found to oscillate in time, similarly to an N-level system. Performing a direct Wigner tomography of the field revealed its nonclassical features, including a Schrödinger cat-like state at half period in the evolution. This fine control of the field in its phase space may enable applications in quantum information and metrology.
description: 5 pages, 4 figures. Supplementary Materials available as an ancillary file here
(400832) Annabella Mill
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Frontolimbic neural circuitry at 6 months predicts individual differences in joint attention at 9 months
Creators: name: Elison, Jed T.
name: Gu, Hongbin
name: Paterson, Sarah J.
name: Piven, Joseph
name: Heimer, Debra C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Elucidating the neural basis of joint attention in infancy promises to yield important insights into the development of language and social cognition, and directly informs developmental models of autism. We describe a new method for evaluating responding to joint attention performance in infancy that highlights the 9 to 10 month period as a time interval of maximal individual differences. We then demonstrate that fractional anisotropy in the right uncinate fasciculus, a white matter fiber bundle connecting the amygdala to the ventral-medial prefrontal cortex and anterior temporal pole, measured in 6 month-olds predicts individual differences in responding to joint attention at 9 months of age. The white matter microstructure of the right uncinate was not related to receptive language ability at 9 months. These findings suggest that the development of core nonverbal social communication skills in infancy is largely supported by preceding developments within right lateralized frontotemporal brain systems.
Determinantal structures in the O'Connell-Yor directed random polymer model
Creators: name: Imamura, Takashi
name: Sasamoto, Tomohiro
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We study the semi-discrete directed random polymer model introduced by O'Connell and Yor. We obtain a representation for the moment generating function of the polymer partition function in terms of a determinantal measure. This measure is an extension of the probability measure of the eigenvalues for the Gaussian Unitary Ensemble (GUE) in random matrix theory. To establish the relation, we introduce another determinantal measure on larger degrees of freedom and consider its few properties, from which the representation above follows immediately.
description: 45 pages, 2 figures
Electronic supplementary material from From conservation genetics to conservation genomics: a genome-wide assessment of blue whales (Balaenoptera musculus) in Australian feeding aggregations.
Creators: name: Attard, Catherine R. M.
name: Beheregaray, Luciano B.
name: Sandoval-Castillo, Jonathan
name: K. Curt S. Jenner
name: Gill, Peter C.
name: Micheline-Nicole M. Jenner
name: Morrice, Margaret G.
name: Möller, Luciana M.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: 60408 Genomics

description: Supplementary methods for SNP data collection, and supplementary methods and results for microsatellites
title: Benign vs. malignant coronary artery anomalies – what do we need to know?
Creators: name: Jankovic, Sonja
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Cardiac
subject: Cardiovascular system
subject: CT
subject: MR
subject: Education
subject: Congenital

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: - To review the clinical importance of coronary artery anomalies (CAAs). - To give an overview of clinical presentation, pathogenesis and imaging features of most common CAAs. - To determine and distinguish benign and malignant coronary artery...
First-trimester maternal vitamin D status and risk for gestational diabetes (GDM) a nested case-control study
Creators: name: Baker, Arthur M.
name: Camargo, Carlos A.
name: Haeri, Sina
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: BACKGROUND: Vitamin D deficiency may contribute to impaired glucose metabolism. There are sparse data regarding vitamin D and the development of gestational diabetes (GDM). The objective of this study was to assess if first-trimester vitamin D deficiency is more prevalent in women later diagnosed with GDM compared with women with uncomplicated pregnancies.

METHODS: We conducted a nested case-control study of pregnant women who had previously given blood for routine genetic multiple marker screening and subsequently delivered at a tertiary hospital between November 2004 and July 2009. From an overall cohort of 4225 women, 60 cases of GDM were matched by race/ethnicity with 120 women delivering at term (≥37 weeks) with uncomplicated pregnancies. Banked maternal serum was used to measure maternal 25-hydroxyvitamin D [25(OH)D].

RESULTS: The prevalence of first-trimester maternal vitamin D deficiency (defined as 25(OH)D < 50 nmol/L) was comparable among women with GDM compared with controls (5/60 vs 8/120, p = 0.90). The median 25(OH)D level for all subjects was 89 nmol/L (interquartile range, 73-106 nmol/L). Seventy three percent (117/160) of the cohort had 25(OH)D levels ≥75 nmol/L.

CONCLUSIONS: In a cohort of pregnant women with mostly sufficient levels of serum 25(OH)D, vitamin D deficiency was not associated with GDM. Further studies are warranted with larger cohorts, especially in populations with lower levels of vitamin D.
Non-Ultralocality and Causality in the Relational Framework of Canonical Quantum Gravity
Creators: name: de Vegvar, P. G. N.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The relational framework of canonical quantum gravity with non-ultralocal constraints is explored. After demonstrating the absence of anomalies, a spatially discretized version of the relational framework is introduced. This allows the application of Lieb-Robinson bounds to on-shell monotonic gauge-flow when there is a continuous external "time" parameter. An explicit Lieb-Robinson bound is derived for the differential on-shell evolution of the operator norm of the commutator of discretized Dirac observables, demonstrating how a local light cone-like causal structure emerges. Ultra-local constraints do not permit such a structure to arise via Lieb-Robinson bounds. Gauge and (3+1)-diff invariance of the light-cone is discussed along with the issues of quantum fluctuations, the nature of the non-localities, the spatial continuum limit, and possible links to non-commutative geometry.
description: 32 pages, 0 figures
(400833) Hugh Robert Mill
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Impact of “Satisfaction of search” (SOS) error on missing new lesions in oncology reads
Creators: name: SHARMA, MANISH
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: eHealth
subject: Oncology
subject: Professional issues
subject: CT
subject: MR
subject: Decision analysis
subject: Health policy and practice
subject: Observer performance
subject: Cancer
subject: Education and training
subject: Metastases

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Satisfaction of search (SOS) indicates an individual’s decrease in vigilance and/or awareness of additional abnormalities once the first abnormality has been identified [1]. Of all types of radiologic diagnostic errors, SOS was the second most...
title: Multiple pulmonary nodules: what a mess!
Creators: name: Affes, Meriem
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Lung
subject: CT
subject: Computer Applications-3D
subject: Tissue characterisation

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: - To review the radiologic features that should be described in front of multiple pulmonary nodules - To describe the radiologic features of the main causes of multiple pulmonary nodules - To review the management of multiple pulmonary nodules with...
(400828) Maria Georgina Mill
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Profound defects in β-cell function in screen-detected type 2 diabetes are not improved with glucose-lowering treatment in the Early Diabetes Intervention Program (EDIP)
Creators: name: Patel, Yash R.
name: Kirkman, M. S.
name: Hannon, Tamara S.
name: Considine, Robert V.
name: Mather, Kieren J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: BACKGROUND: Few studies have measured the ability of interventions to affect declining β-cell function in screen-detected type 2 diabetes. The Early Diabetes Intervention Programme (ClinicalTrials.gov NCT01470937) was a randomized study based on the hypothesis that improving postprandial glucose excursions with acarbose would slow the progression of fasting hyperglycaemia in screen-detected type 2 diabetes. In the Early Diabetes Intervention Programme, the effect of acarbose plus lifestyle advice on progression of fasting hyperglycaemia over a 5-year period was not greater than that of placebo. However, there was an early glucose-lowering effect of the trial. The objective of the current secondary analysis was to describe β-cell function changes in response to glucose lowering.

METHODS: Participants were overweight adult subjects with screen-detected type 2 diabetes. β-cell function was measured using hyperglycaemic clamps and oral glucose tolerance testing. The primary outcome was the change in β-cell function from baseline to year 1, the time point where the maximal glucose-lowering effect was seen.

RESULTS: At baseline, participants exhibited markedly impaired first-phase insulin response. Despite significant reductions in weight, fasting plasma glucose (PG) and 2-h PG, there was no clinically significant improvement in the first-phase insulin response. Late-phase insulin responses declined despite beneficial glycaemic effects of interventions.

CONCLUSIONS: Insulin secretion is already severely impaired in early, screen-detected type 2 diabetes. Effective glucose-lowering intervention with acarbose was not sufficient to improve insulin secretion or halt the decline of β-cell function.
title: Sarcoid-like conditions in patients with cancer: Contribution of imaging to the diagnosis
Creators: name: Affes, Meriem
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Oncology
subject: CT
subject: Diagnostic procedure
subject: Metastases

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Sarcoidosis is a systemic inflammatory disease that can affect many organs with the development of non-caseating granulomas. In some cases, It has been associated with malignant tumors, but the link between cancer or cancer treatment and sarcoidosis...
(400829) Agnes Mill
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Electronic supplementary material from Conservation genetics to conservation genomics: a genome-wide assessment of blue whales (Balaenoptera musculus) in Australian feeding aggregations
Creators: name: Attard, Catherine R. M.
name: Beheregaray, Luciano B.
name: Sandoval-Castillo, Jonathan
name: K. Curt S. Jenner
name: Gill, Peter C.
name: Micheline-Nicole M. Jenner
name: Morrice, Margaret G.
name: Möller, Luciana M.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: 60408 Genomics

description: Supplementary methods for SNP data collection, and supplementary methods and results for microsatellites
title: A Review of Common Injury Patterns in a Major Trauma Centre
Creators: name: Sim, WH
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Trauma
subject: CT
subject: Plain radiographic studies
subject: Complications
subject: Health policy and practice
subject: Statistics
subject: FOS: Mathematics
subject: Trauma

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Electric scooters or E- Scooters are becoming a popular mode of transportation for adults. In Ireland, no definite regulations exist. E-scooters can continuously operate without “pedaling or scooting”, hence, the Road Safety Authority of Ireland...
LEADER 2: baseline calcitonin in 9340 people with type 2 diabetes enrolled in the Liraglutide Effect and Action in Diabetes: Evaluation of cardiovascular outcome Results (LEADER) trial: preliminary observations
Creators: name: Moses, A. C.
name: Derving Karsbøl, J.
name: Mann, J. F. E.
name: Bergenstal, R. M.
name: Nauck, M. A.
name: Marso, S. P.
name: Hegedüs, L.
name: Tuttle, R. M.
name: Zinman, B.
name: Daniels, G. H.
name: Buse, J. B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: AimsTo report preliminary data on baseline serum calcitonin concentrations and associated clinical characteristics in a global population with type 2 diabetes before liraglutide or placebo randomization.MethodsThe ongoing LEADER trial has enrolled 9340 people with type 2 diabetes and at high risk of cardiovascular disease at 410 centres worldwide. People with baseline serum calcitonin ≤50 ng/l were randomized to liraglutide once daily or placebo and will be followed for up to 5 years. Serum calcitonin was measured at baseline and will be measured annually thereafter. An independent committee of thyroid experts will oversee calcitonin monitoring throughout the trial and will review all calcitonin concentrations ≥20 ng/l.ResultsThe mean age of participants was 64.3 ± 7.2 years, 64.3% were men, and mean the body mass index was 32.5 ± 6.3 kg/m2. The median (interquartile range) baseline serum calcitonin values were 3.9 (1.0 to >7.6) ng/l in men and 1.0 (1.0 to >1) ng/l in women. Serum calcitonin was >10 ng/l in 14.6% of men and in 0.96% of women. In sex-specific multivariable linear analysis of covariance models, a reduced glomerular filtration rate (GFR) was associated with higher serum calcitonin concentrations that were statistically significant. A 20 ml/min/1.73 m2 decrease in estimated GFR (eGFR) was associated with a 14% increase in serum calcitonin in women and an 11% increase in men.ConclusionsIn the LEADER population, the prevalence of elevated serum calcitonin concentrations at baseline was high, and there was an inverse association between eGFR and serum calcitonin concentrations.
Supplementary Material - Analog Neuro-memristive Convolutional Dropout Nets from Analogue neuro-memristive convolutional dropout nets
Creators: name: O. Krestinskaya
name: James, A. P.
Publisher: name: The Royal Society
Year: 2020
Subjects: subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences
subject: 90699 Electrical and Electronic Engineering not elsewhere classified
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Technical details for simulations
One-year efficacy and safety of a fixed combination of insulin degludec and liraglutide in patients with type 2 diabetes: results of a 26-week extension to a 26-week main trial
Creators: name: Gough, S. C. L.
name: Linjawi, S.
name: Rodbard, H. W.
name: Reiter, P. D.
name: Bode, B. W.
name: Zacho, M.
name: Buse, J. B.
name: Woo, V. C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: AimsTo confirm, in a 26‐week extension study, the sustained efficacy and safety of a fixed combination of insulin degludec and liraglutide (IDegLira) compared with either insulin degludec or liraglutide alone, in patients with type 2 diabetes.MethodsInsulin‐naïve adults with type 2 diabetes randomized to once‐daily IDegLira, insulin degludec or liraglutide, in addition to metformin ± pioglitazone, continued their allocated treatment in this preplanned 26‐week extension of the DUAL I trial.ResultsA total of 78.8% of patients (1311/1663) continued into the extension phase. The mean glycated haemoglobin (HbA1c) concentration at 52 weeks was reduced from baseline by 1.84% (20.2 mmol/mol) for the IDegLira group, 1.40% (15.3 mmol/mol) for the insulin degludec group and 1.21% (13.2 mmol/mol) for the liraglutide group. Of the patients on IDegLira, 78% achieved an HbA1c of <7% (53 mmol/mol) versus 63% of the patients on insulin degludec and 57% of those on liraglutide. The mean fasting plasma glucose concentration at the end of the trial was similar for IDegLira (5.7 mmol/l) and insulin degludec (6.0 mmol/l), but higher for liraglutide (7.3 mmol/l). At 52 weeks, the daily insulin dose was 37% lower with IDegLira (39 units) than with insulin degludec (62 units). IDegLira was associated with a significantly greater decrease in body weight (estimated treatment difference, −2.80 kg, p < 0.0001) and a 37% lower rate of hypoglycaemia compared with insulin degludec. Overall, all treatments were well tolerated and no new adverse events or tolerability issues were observed for IDegLira.ConclusionsThese 12‐month data, derived from a 26‐week extension of the DUAL I trial, confirm the initial 26‐week main phase results and the sustainability of the benefits of IDegLira compared with its components in glycaemic efficacy, safety and tolerability.
title: The role of cardiac magnetic resonance imaging in patients after COVID-19 infection without previous cardiovascular disease
Creators: name: Nedeljkovic-Arsenovic, Olga
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Cardiac
subject: MR
subject: Complications
subject: Education and training

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: The Coronavirus Disease 2019 (COVID-19) is a global pandemic infection affecting millions people. The manifestations of COVID-19 are widely variable and range from asymptomatic infection to multi-organ failure and death. (1) Recent research...
title: Intussusception in adults: in search of organic causes.
Creators: name: Marín Pérez, Celia
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Emergency
subject: Small bowel
subject: CT
subject: Education
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Revisar las diferentes causas orgánicas de intususcepción intestinal en adultos y sus hallazgos por imagen. Exponer las intususcepciones intestinales clasificadas según su localización y etiología. Identificar signos directos e indirectos en la...
title: Management of hemoptysis in radiology: From diagnosis to endovascular treatment
Creators: name: Jelassi, Achref
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Lung
subject: Pulmonary vessels
subject: Vascular
subject: CT
subject: Education
subject: Embolisation
subject: Haemorrhage

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: In this pictorial essay, our aim was to present a comprehensive review of hemoptysis, analyzing its causes and providing details of the imaging anatomy of bronchial and nonbronchial arteries commonly responsible for hemoptysis. Endovascular...
(400830) Harriet Elizabeth Mill
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Vitamin D in youth with Type 1 diabetes: prevalence of insufficiency and association with insulin resistance in the SEARCH Nutrition Ancillary Study
Creators: name: Lawrence, J. M.
name: Norris, J. M.
name: King, I. B.
name: Crandell, J. L.
name: Pihoker, C.
name: Mayer-Davis, E. J.
name: The, N. S.
name: Marcovina, S. M.
name: D'Agostino, R. B.
name: Dabelea, D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: To determine the prevalence of plasma vitamin D insufficiency in individuals with Type 1 diabetes and to determine the cross-sectional and longitudinal associations of plasma vitamin D with insulin resistance.
Impurity Bound States and Greens Function Zeroes as Local Signatures of Topology
Creators: name: Slager, Robert-Jan
name: Rademaker, Louk
name: Zaanen, Jan
name: Balents, Leon
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We show that the local in-gap Greens function of a band insulator $\mathbf{G}_0 (ε,\mathbf{k}_{\parallel},\mathbf{r}_{\perp}=0)$, with $\mathbf{r}_\perp$ the position perpendicular to a codimension-1 or -2 impurity, reveals the topological nature of the phase. For a topological insulator, the eigenvalues of this Greens function attain zeros in the gap, whereas for a trivial insulator the eigenvalues remain nonzero. This topological classification is related to the existence of in-gap bound states along codimension-1 and -2 impurities. Whereas codimension-1 impurities can be viewed as 'soft edges', the result for codimension-2 impurities is nontrivial and allows for a direct experimental measurement of the topological nature of 2d insulators.
description: 11 pages, 8 figures
title: COMPARISON OF ULTRASONOGRAPHY LEARNING BETWEEN DISTANCE TEACHING AND TRADITIONAL METHODOLOGY. A review
Creators: name: duarte, Marcio Luis
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Computer applications
subject: Ultrasound
subject: eLearning
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To assess whether the effectiveness of distance learning and/or e-learning, m-learning, and web-based methods are equivalent to traditional...
Bayesian model selection without evidences: application to the dark energy equation-of-state
Creators: name: Hee, Sonke
name: Handley, Will
name: Hobson, Mike P.
name: Lasenby, Anthony N.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: A method is presented for Bayesian model selection without explicitly computing evidences, by using a combined likelihood and introducing an integer model selection parameter $n$ so that Bayes factors, or more generally posterior odds ratios, may be read off directly from the posterior of $n$. If the total number of models under consideration is specified a priori, the full joint parameter space $(θ, n)$ of the models is of fixed dimensionality and can be explored using standard Markov chain Monte Carlo (MCMC) or nested sampling methods, without the need for reversible jump MCMC techniques. The posterior on $n$ is then obtained by straightforward marginalisation. We demonstrate the efficacy of our approach by application to several toy models. We then apply it to constraining the dark energy equation-of-state using a free-form reconstruction technique. We show that $Λ$CDM is significantly favoured over all extensions, including the simple $w(z){=}{\rm constant}$ model.
description: Published in MNRAS. Article is 13 pages long including 12 figures, 3 tables and 2 appendices
title: Orthopedic devices: a practical guide for its correct interpretation and not die trying.
Creators: name: Polania, Albert
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Bones
subject: Extremities
subject: Musculoskeletal system
subject: CT
subject: Digital radiography
subject: Plain radiographic studies
subject: Complications
subject: Diagnostic procedure
subject: Instrumentation
subject: Congenital
subject: Prostheses
subject: Trauma

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Explain the main indications for the use of orthopedic devices. Review the most used orthopedic hardware, describing its appearance on imaging, functions, characteristics, and possible...
(400827) Agnes Pitrie
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Sample preparation and qPCR_Nyman_etal from Evolutionary conserved neural signature of early life stress affects animal social competence.
Creators: name: Nyman, Cecilia
name: Fischer, Stefan
name: Aubin-Horth, Nadia
name: Taborsky, Barbara
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Molecular Biology
subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Sample preparation and qPCR for gene expression data
Adolescents with Type 1 diabetes mellitus experience psychosensorial symptoms during hypoglycaemia
Creators: name: Meyer, E.
name: Helms, S.
name: Calikoglu, A. S.
name: Yeşiltepe-Mutlu, G.
name: Çizmecioğlu, F.
name: Özsu, E.
name: Law, J. R.
name: Hatun, Ş.
name: Lin, F.C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: AimTo describe mood and psychosensorial symptoms of hypoglycaemia in adolescents with Type 1 diabetes mellitus in two countries with different cultures, Turkey and the USA.MethodsWe developed a 68-item questionnaire assessing physical, behavioural, mood and psychosensorial symptom frequency and ratings [‘good’, ‘bad’, or ‘both’ (sometimes good, sometimes bad)]. Adolescents with Type 1 diabetes were recruited from paediatric diabetes clinics at the University of North Carolina at Chapel Hill in the USA and Kocaeli University in Turkey. The percentages of participants at each clinic who endorsed individual symptoms, symptom categories and symptom ratings were calculated and compared.ResultsCronbach’s α values were > 0.7 for each real symptom category. No symptom items were excluded from the questionnaire analysis based on item-total correlation results which were all > 0.2. Data were collected from 132 participants (69 from University of North Carolina, 63 from Kocaeli University, 54% male). The mean (sd) age of the participants was 14.9 (1.9) years, HbA1c level was 8.7 (1.8) % and duration of Type 1 diabetes was 5.8 (3.7) years. On average, each physical symptom was experienced by 65.2% of participants, each behavioural symptom by 46.5%, each mood symptom by 42.8%, and each psychosensorial symptom by 48.9%. On average, each physical, behavioral, mood and psychosensorial symptom was rated as ‘good’ or ‘both’ by 23.0, 29.1, 36.9 and 37.2% of participants, respectively. There were no symptom differences between the groups in each country.ConclusionsIn addition to the classic physical symptoms experienced during hypoglycaemia, adolescents with Type 1 diabetes report psychosensorial, mood and behavioral symptoms, and some describe them as positive experiences. Symptom experiences were similar in these two countries with different cultures.
title: General academic test in the evaluation of Medicine courses in Brazil and the increase in questions with Radiology content.
Creators: name: Ferreira, Caio
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Paediatric
subject: Thorax
subject: Conventional radiography
subject: CT
subject: Ultrasound
subject: Diagnostic procedure
subject: Education
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: In Brazil, there are assessment tests during every university course conducted by the federal government named the National Student Performance Exam (ENADE). They are applied at the end of the second, fourth and, if applicable, sixth years, in...
Long-term changes in dietary and food intake behaviour in the Diabetes Prevention Program Outcomes Study
Creators: name: Kriska, A. M.
name: Davis, N.
name: Delahanty, L. M.
name: Venditti, E. M.
name: Isonaga, M.
name: Wylie-Rosett, J.
name: Franks, P. W.
name: Mayer-Davis, E. J.
name: Brown-Friday, J.
name: Jaacks, L. M.
name: Ma, Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: To 1) compare change in dietary intake, with an emphasis on food groups and food behaviors, over time across treatment arms in a diabetes prevention trial and 2) assess differences in dietary intake across demographic groups within treatment arms.
Sample preparation and qPCR_Nyman_etal from Evolutionary conserved neural signature of early life stress affects animal social competence
Creators: name: Nyman, Cecilia
name: Fischer, Stefan
name: Aubin-Horth, Nadia
name: Taborsky, Barbara
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Molecular Biology
subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Sample preparation and qPCR for gene expression data
title: Evaluation of non-palpable breast lesions by quantitative magnetic resonance imaging in correlation with histopathology and radiological findings.
Creators: name: Malikova, Marina
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Breast
subject: Experimental
subject: Mammography
subject: MR
subject: Biopsy
subject: Computer Applications-Detection, diagnosis
subject: Calcifications / Calculi

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Perform radiological evaluation of calcifications in breast lesions. Correlate findings with histopathology and quantitative magnetic resonance imaging (qMRI), using T1/T2 ratios as a potential biomarker for...
Robust state transfer with high fidelity in spin-1/2 chains by Lyapunov control
Creators: name: Shi, Z. C.
name: Zhao, X. L.
name: Yi, X. X.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Based on the Lyapunov control, we present a scheme to realize state transfer with high fidelity by only modulating the boundary spins in a quantum spin-1/2 chain. Recall that the conventional transmission protocols aim at nonstationary state (or information) transfer from the first spin to the end spin at a fixed time. The present scheme possesses the following advantages. First, the scheme does not require precise manipulations of the control time. Second, it is robust against uncertainties in the initial states and fluctuations in the control fields. Third, the controls are exerted only on the boundary sites of the chain. It works for variable spin-1/2 chains with different periodic structures and has good scalability. The feasibility to replace the control fields by square pules is explored, which simplifies the realization in experiments.
(400823) James A Mill
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: MRI for rectal cancer restaging: Current challenges and new advances
Creators: name: García Ferrer, Manuel
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Colon
subject: Oncology
subject: MR
subject: Chemotherapy
subject: Radiation therapy / Oncology
subject: Treatment effects
subject: Radiotherapy techniques

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To describe the role of MRI in the evaluation of rectal cancer response to neoadjuvant chemoradiation therapy. To review how rectal cancer restaging MRI is interpreted and reported according to current guidelines. To identify common sources of...