cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Early Origins of Childhood Asthma: Role of Perinatal Microbial Exposure and Innate Immunity
Creators: name: Turturice, Benjamin Arthur
Publisher: name: University of Illinois at Chicago
Year: 2021
Subjects: Uncategorized

description: Asthma—defined by reversible expiratory airflow obstruction-- is the most common chronic disease of childhood in the United States. While many triggers (e.g. bacteria, viruses, allergens, and pollution) have been identified as causative agents of asthma, there is no single etiology that drives reversible obstruction children. The pathogenesis of childhood asthma likely stems from an individual x environment interaction that is highly complex. The focus of the studies of the Finn-Perkins lab described here was to identify microbial exposures and immunological differences at birth that are predictive of asthma development, asthmatic response to triggers, and severity of asthmatic symptoms. Although there is no known single etiologic agent, children with asthma have demonstrable skewing of T-cell responses toward Th2 or “allergic” processes. Using an unbiased approach, we assessed relationships between perinatal microbial exposure and Th2 responses to common air-borne allergens that are known asthma triggers. We identified a specific phyla of Gram negative organisms, Proteobacteria, with negative associations with Th2 responses. Further, increased abundance of Proteobacteria was significantly associated with reduced risk of wheezing childhood. Together, this is suggestive of a protective role of early exposure to Proteobacteria. While Th2 responses are a hallmark of childhood asthma, it is not clear what predisposes to this immunologic skewing later in childhood. There are many risk factors for childhood asthma that have been identified, and many of these are discernable at birth (e.g. sex, mode of delivery, gestational age…). We demonstrated that the pre/perinatal risk factors have additive effects and in using an unbiased approach, we were able to identify a transcriptional signature associated with pre/perinatal risk stratification. xiv Additionally, we determined that umbilical cord serum PGLYRP-1 concentrations were predictive of this transcriptional signature, current asthma at 7 years old, and FEV1/FVC at 12 years old. The concentration of PGLYRP-1 was associated with perinatal exposure to Proteobacteria and several Proteobacteria genera. Collectively, this suggests that early exposure to Proteobacteria enhances innate immunity and, through enhanced innate immunity, may protect against future development of asthma. Additionally, these findings demonstrate that accurate prediction of asthma risk may be capable at birth using a serological marker, PGLYRP-1.
METTL21C mediates lysine trimethylation of IGF2BP1 to regulate chicken myoblast proliferation
Creators: name: Wang, Shanshan
name: Zhao, Jiarong
name: Wang, Ling
name: Zhang, Tao
name: Zeng, Wenxian
name: Lu, Hongzhao
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: 1. Methyltransferase-like 21C (METTL21C) and insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) play important roles in the proliferation of chicken myoblasts. However, it remains unclear whether there is protein-protein interaction between METTL21C and IGF2BP1 to regulate proliferation of chicken myoblasts. 2. In this study, the Igf2bp1 gene was amplified from cDNA of liver tissue of Lueyang black-bone chicken to construct the overexpression vector HA-Igf2bp1. The HA-Igf2bp1 and Flag-Mettl21c vectors were individually transfected and co-transfected into HEK293T, respectively. Co-immunoprecipitation (Co-IP) assay indicated a protein-protein interaction between METTL21C and IGF2BP1. 3. Using the Western blotting and LC-MS/MS, it was found that METTL21C could mediate the lysine methylation modification of IGF2BP1. Furthermore, the His-tagged overexpression vector HA-Igf2bp1-His was constructed, transfected and co-transfected with Flag-Mettl21c into HEK293T. His-tagged IGF2BP1 was purified by nickel ion affinity chromatography. Western blotting revealed that IGF2BP1 was successfully purified, and the trimethylation modification level of co-transfection group was significantly elevated compared with the single-transfection Igf2bp1 group. 4. Mettl21c and Igf2bp1 overexpression vectors were transfected and co-transfected into primary chicken myoblasts, respectively. The results of 5-ethynyl-2’-deoxyuridine assay and the expression level of Pax7 and MyoD indicated that overexpression of Igf2bp1 alone inhibited the chicken myoblast proliferation, whereas co-expression of Mettl21c and Igf2bp1 eliminated the inhibitory effects of Igf2bp1, thereby favouring cell proliferation and differentiation. 5. The results, for the first time, revealed that METTL21C mediated the lysine trimethylation modification of IGF2BP1 to regulate the proliferation of chicken myoblasts, which provided a new insight into in-depth analysis of the molecular mechanism of METTL21C methylation involved in regulating the growth and development of skeletal muscle in Lueyang black-bone chicken.
Additional file 1 of Payment systems for dialysis and their effects: a scoping review
Creators: name: Emrani, Zahra
name: Amiresmaili, Mohammadreza
name: Daroudi, Rajabali
name: Najafi, Mohammad Taghi
name: Akbari Sari, Ali
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1: Table S1. Database Search Strategies. Table S2. Articles description. Table S3. Indicators classifications.
Towards Optimal Variance Reduction in Online Controlled Experiments
Creators: name: Jin, Ying
name: Ba, Shan
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Medicine
Molecular Biology
Biotechnology
Mathematical Sciences not elsewhere classified

description: We study optimal variance reduction solutions for count and ratio metrics in online controlled experiments. Our methods apply flexible machine learning tools to incorporate covariates that are independent from the treatment but have predictive power for the outcomes, and employ the cross-fitting technique to remove the bias in complex machine learning models. We establish CLT-type asymptotic inference based on our estimators under mild convergence conditions. Our procedures are optimal (efficient) for the corresponding targets as long as the machine learning estimators are consistent, without any requirement for their convergence rates. In complement to the general optimal procedure, we also derive a linear adjustment method for ratio metrics as a special case that is computationally efficient and can flexibly incorporate any pre-treatment covariates. We evaluate the proposed variance reduction procedures with comprehensive simulation studies and provide practical suggestions regarding commonly adopted assumptions in computing ratio metrics. When tested on real online experiment data from LinkedIn, the proposed optimal procedure for ratio metrics can reduce up to 80% of variance compared to the standard difference-in-mean estimator and also further reduce up to 30% of variance compared to the CUPED approach by going beyond linearity and incorporating a large number of extra covariates.
Cosmological MHD Simulations of Galaxy Cluster Radio Relics: Insights and Warnings for Observations
Creators: name: Skillman, Samuel W.
name: Xu, Hao
name: Hallman, Eric J.
name: O'Shea, Brian W.
name: Burns, Jack O.
name: Li, Hui
name: Collins, David C.
name: Norman, Michael L.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Non-thermal radio emission from cosmic ray electrons in the vicinity of merging galaxy clusters is an important tracer of cluster merger activity, and is the result of complex physical processes that involve magnetic fields, particle acceleration, gas dynamics, and radiation. In particular, objects known as radio relics are thought to be the result of shock-accelerated electrons that, when embedded in a magnetic field, emit synchrotron radiation in the radio wavelengths. In order to properly model this emission, we utilize the adaptive mesh refinement simulation of the magnetohydrodynamic evolution of a galaxy cluster from cosmological initial conditions. We locate shock fronts and apply models of cosmic ray electron acceleration that are then input into radio emission models. We have determined the thermodynamic properties of this radio-emitting plasma and constructed synthetic radio observations to compare to observed galaxy clusters. We find a significant dependence of the observed morphology and radio relic properties on the viewing angle of the cluster, raising concerns regarding the interpretation of observed radio features in clusters. We also find that a given shock should not be characterized by a single Mach number. We find that the bulk of the radio emission comes from gas with T>5x10^7, ρ~10^(-28)-10^(-27) g/cm^3, with magnetic field strengths of 0.1-1.0 μG and shock Mach numbers of M~3-6. We present an analysis of the radio spectral index which suggests that the spatial variation of the spectral index can mimic synchrotron aging. Finally, we examine the polarization fraction and position angle of the simulated radio features, and compare to observations.
description: 18 pages. Submitted to ApJ. Posted after first revision
CircSUCO promotes proliferation and differentiation of chicken skeletal muscle satellite cells via sponging miR-15
Creators: name: Tian, Yongtong
name: Shen, Xiaoxu
name: Zhao, Jing
name: Wei, Yuanhang
name: Han, Shunshun
name: Yin, Huadong
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: 1. In a previous high-throughput sequencing study, a novel circular RNA (circRNA) generated from a SUN domain containing ossification factor (SUCO) gene transcript (circSUCO) was differentially expressed during the embryonic muscle development. This study aimed to further explore the effect of circSUCO on chicken skeletal muscle development. 2. The experiment analysed the expression patterns of circSUCO in Tianfu broilers and clarified its function in the chicken skeletal muscle satellite cells (SMSC) after circSUCO knockdown. The qPCR results showed circSUCO was highly expressed in skeletal muscle and has different expression levels during various development periods. 3. Mechanistically, a series of in vitro experiments showed that circSUCO interference suppressed proliferation and differentiation of SMSC. In addition, it was observed that circSUCO competitively binds with microRNAs such as miR-15a, miR-15b-5p, and miR-15c-5p according to the dual-luciferase assay and qPCR. 4. Correlation was positive between the circSUCO expression level and the ratio of the breast muscle. The results revealed that circSUCO could play a positive role in proliferation and differentiation of SMSC via sponging miR-15a, miR-15b-5p, and miR-15c-5p, hence, may contribute to skeletal muscle development in chicken.
The Ignition of Carbon Detonations via Converging Shock Waves in White Dwarfs
Creators: name: Shen, Ken J.
name: Bildsten, Lars
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The progenitor channel responsible for the majority of Type Ia supernovae is still uncertain. One emergent scenario involves the detonation of a He-rich layer surrounding a C/O white dwarf, which sends a shock wave into the core. The quasi-spherical shock wave converges and strengthens at an off-center location, forming a second, C-burning, detonation that disrupts the whole star. In this paper, we examine this second detonation of the double detonation scenario using a combination of analytic and numeric techniques. We perform a spatially resolved study of the imploding shock wave and outgoing detonation and calculate the critical imploding shock strengths needed to achieve a core C detonation. We find that He detonations in recent two-dimensional simulations yield converging shock waves that are strong enough to ignite C detonations in high-mass C/O cores, with the caveat that a truly robust answer requires multi-dimensional detonation initiation calculations. We also find that convergence-driven detonations in low-mass C/O cores and in O/Ne cores are harder to achieve and are perhaps unrealized in standard binary evolution.
description: Accepted for publication in The Astrophysical Journal
Asymptotic behavior of the Kawazumi-Zhang invariant for degenerating Riemann surfaces
Creators: name: de Jong, Robin
Publisher: name: arXiv
Year: 2012
Subjects: subject: Algebraic Geometry (math.AG)
subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 14H15 (Primary) 14D06, 32G20 (Secondary)

description: Around 2008 N. Kawazumi and S. Zhang introduced a new fundamental numerical invariant for compact Riemann surfaces. One way of viewing the Kawazumi-Zhang invariant is as a quotient of two natural hermitian metrics with the same first Chern form on the line bundle of holomorphic differentials. In this paper we determine precise formulas, up to and including constant terms, for the asymptotic behavior of the Kawazumi-Zhang invariant for degenerating Riemann surfaces. As a corollary we state precise asymptotic formulas for the beta-invariant introduced around 2000 by R. Hain and D. Reed. These formulas are a refinement of a result Hain and Reed prove in their paper. We illustrate our results with some explicit calculations on degenerating genus two surfaces.
description: 17 pages
Threading dislocation densities in semiconductor crystals: a geometric approach
Creators: name: Bakke, K.
name: Moraes, F.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: In this letter, we introduce a geometric model to explain the origin of the observed shallow levels in semiconductors threaded by a dislocation density. We show that a uniform distribution of screw dislocations acts as an effective uniform magnetic field which yields bound states for a spin-half quantum particle, even in the presence of a repulsive Coulomb-like potential. This introduces energy levels within the band gap, increasing the carrier concentration in the region threaded by the dislocation density and adding additional recombination paths other than the near band-edge recombination.
description: 9 pages, no figure
Planting Composition Effects on Tropical Forest Restoration
Creators: name: Beltran Lacouture, Luis C
Publisher: name: University of Illinois at Chicago
Year: 2021
Subjects: Uncategorized

description: Deforestation in the Neotropics is driven primarily by the demand for pastureland for cattle. For pastures unlikely to transition back to forest, a proposed solution is establishing fenced restoration plantings throughout the pastures as stepping-stone biological corridors between forest fragments. Most tropical tree species are animal-dispersed, so in selecting species for plantings, animal-dispersed trees are favored as they attract more dispersal agents. However, whether the enhanced seed dispersal results in plantings that more closely resemble the forest has not been experimentally demonstrated. Between 2018 and 2019, I visited a restoration plantings experiment established in 2006 in Los Tuxtlas, Veracruz, Mexico to compare among and evaluate which of three treatments (plantings of animal-dispersed species, plantings of wind-dispersed species, and unplanted plots that simulate natural succession) most closely resembled the primary forest. First, I compared by forest structure by measuring the diameter and identifying every tree (> 2 m tall) in the experiment and in forest plots of equal size to the treatments. I found that animal-plantings most closely resembled the forest. Next comparison was by invasibility to the swordtail fern (Nephrolepis brownii), an invasive species seldom found in the forest. I found that the invasion was most acute (densest and longest fern fronds) in the natural succession plots and least acute in animal-plantings. Following that, I evaluated soil nutrient concentrations. Nitrate was marginally higher in animal-plantings soil, more closely approximating the forest. Fourth comparison was in foraging intensity by cricetid rodents largely absent in the forest, which I conducted using experimental food patches with millet seeds mixed with sand as substrate. I found that foraging was most intense in both animal-plantings and natural succession plots. My dissertation is capped off with a perspective piece on the differential roles that dispersal agent species play in the restoration of plantings in fragmented landscapes. The combined results of this dissertation and previous research that evaluated other key variables suggest that selecting animal-dispersed over wind-dispersed species is most effective towards establishing plantings that more closely resemble the forest. We expect stronger differences between treatments to manifest as the experiment matures.
Zinc ferrate nanoparticles for applications in medicine: synthesis, physicochemical properties, regulation of macrophage functions, and in vivo safety evaluation
Creators: name: Wang, Yu
name: Liu, Yajie
name: Li, Jiajia
name: Xu, Xiaoqing
name: Li, Xinru
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Zinc ferrate nanoparticles (ZnFe2O4 NPs) have attracted enormous interest as potential nanomaterials. The purpose of this study was to examine the in vitro macrophages toxicity, in vivo safety, and immunogenicity. Three kinds of ZnFe2O4 NPs with different shapes (round, litchi, and raspberry), nano-sizes, and pores were successfully prepared. In vitro experiments showed that ZnFe2O4 NPs caused no cytotoxicity against the RAW 264.7 cells up to administered dose of 200 μg/mL, enhanced proinflammatory cytokine TNF-α, and costimulatory marker CD86 expression in the RAW 264.7 cells. Interestingly, ZnFe2O4 NPs reduced ROS expression, which was inconsistent with common metal oxide NPs such as iron oxide (Fe3O4) NPs and zinc oxide (ZnO) NPs. ZnFe2O4 NPs improved the RAW 264.7 cells phagocytosed more neutral red. There was no obvious difference in body weight, the number of immune cells, organ index, and expression of inflammatory factors in serum of rats administrated intravenously and subcutaneously on day 21 after treatment by ZnFe2O4 NPs in comparison with the blank control. These results demonstrated that ZnFe2O4 NPs slightly enhanced the function of the RAW 264.7 cells in vitro but caused no obvious toxicity to macrophages as well as rat blood cells, and low immunogenicity in rats, suggesting that ZnFe2O4 NPs as a biocompatible nanomaterials achieved potential for bioapplication in the future.
Additional file 1 of HPV vaccination leads to decrease of anogenital warts and precancerous lesions of the cervix uteri in young women with low vaccination rates: a retrospective cohort analysis
Creators: name: Osmani, Vanesa
name: Fett, Sandra
name: Tauscher, Martin
name: Donnachie, Ewan
name: Schneider, Antonius
name: Klug, Stefanie J.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Table S1. HPV vaccination rates among 12-, 18- and 9 to 17- year-old females during 2012-2018. Table S2. Kaplan-Meier estimates of survival function referring to time until anogenital warts diagnosis by vaccination status. Table S3. Kaplan-Meier estimates of survival function referring to time until anogenital warts diagnosis by vaccination status and vaccine type. Table S4. Kaplan-Meier estimates of survival function referring to time until anogenital warts diagnosis by vaccination status and contraceptive prescription. Table S5. Kaplan-Meier estimates of survival function referring to time until cervical lesions diagnosis by vaccination status. Table S6. Kaplan-Meier estimates of survival function referring to time until cervical lesions diagnosis by vaccination status and vaccine type. Table S7. Kaplan-Meier estimates of survival function referring to time until cervical lesions diagnosis by vaccination status and contraceptive prescription. Table S8. Univariable Cox regression model results regarding risk to develop genital warts or precancerous lesions in young women. Table S9. HPV vaccination rates in 2018, according to the year of birth (age in years). Table S10. HPV vaccine type administered in Bavaria between 2008 and 2018.
Searching for axions and ALPs from string theory
Creators: name: Ringwald, Andreas
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We review searches for closed string axions and axion-like particles (ALPs) in IIB string flux compactifications. For natural values of the background fluxes and TeV scale gravitino mass, the moduli stabilisation mechanism of the LARGE Volume Scenario predicts the existence of a QCD axion candidate with intermediate scale decay constant, f_a ~ 10^9 ... 10^12 GeV, associated with the small cycles wrapped by the branes hosting the visible sector, plus a nearly massless and nearly decoupled ALP associated with the LARGE cycle. In setups where the visible sector branes are wrapping more than the minimum number of two intersecting cycles, there are more ALPs which have approximately the same decay constant and coupling to the photon as the QCD axion candidate, but which are exponentially lighter. There are exciting phenomenological opportunities to search for these axions and ALPs in the near future. For f_a ~ 10^11 ... 10^12 GeV, the QCD axion can be the dominant part of dark matter and be detected in haloscopes exploiting microwave cavities. For f_a ~ 10^9 ... 10^10 GeV, the additional ALPs could explain astrophysical anomalies and be searched for in the upcoming generation of helioscopes and light-shining-through-a-wall experiments.
description: 12 pages, 3 figures, based on plenary talk at PASCOS 2012, Merida, Mexico, June 3-8, 2012
title: Therapeutic Strategies Targeting MYC Oncogene Vulnerabilities in Breast Cancer
Creators: name: (:Unkn) Unknown
Publisher: name: University of Helsinki
Year: 2024
Subjects: subject: biological data
subject: human data
subject: mice data
subject: sequencing data
subject: Life Science Research Data
subject: Breast Neoplasms
subject: Oncogenes
subject: MYC Genes
subject: Gene Signature
subject: RNA-Seq [MeSH]

description: Our current research specifically focuses on therapeutic strategies aiming to exploit MYC oncogene-induced vulnerabilities and therapeutically intervenable oncogenic functions in human breast cancer. Sequencing data is from our lab and also from public sources. The sample data has been collected within a period of 10 years approx from human and mice.
Distribution of Polycyclic Aromatic Hydrocarbons in Leaked Crankcase Oil of Parking Facilities
Creators: name: Zabarmawi, Muna M
Publisher: name: University of Illinois at Chicago
Year: 2021
Subjects: Uncategorized

description: Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants that are produced in the environment naturally or anthropogenically. Many high-molecular weight PAHs are considered carcinogens or possibly carcinogenic to humans. Used crankcase oil is one of the major PAH sources in urban environments. When engine runs, PAHs are generated and accumulate in oil and when crankcase oil leaks onto parking surfaces, oil stains become PAH sources. This study measures PAH concentrations and estimates their distributions in leaked crankcase oil of two parking facilities: a covered concrete parking structure and an open asphalt parking lot. A total of 120 samples of oil stains, parking background, and parking dust were collected from the covered parking structure and the open parking lot and analyzed for PAHs by gas chromatography-mass spectrometry (GC-MS). Additionally, the chromatogram unresolved complex mixtures (UCM) of crankcase oil stains were examined by applying baseline filtering method (baseline estimation and denoising with sparsity; BEADS algorithm). In the covered parking, used oil is the predominant source of PAHs and PAH concentrations decreases significantly as oil stains age. In addition, in the covered parking, PAHs ratios suggest that biodegradation is the major process of PAH attenuation. In the open parking, asphalt pavement and coal-tar sealant are the predominant sources of PAH and this PAH signal overwhelms any PAH signal derived from leaked crankcase oil. For the open parking, comparison of gas-chromatographic retention time at the second quartile suggest a significant and early loss of low-molecular weight hydrocarbons of base oil, suggesting efficient base oil attenuation processes. In contrast, covered parking samples exhibit a very limited increase in retention time at the second quartile with increasing stain age, demonstrating the limited process of attenuation affecting base oil in stains of the covered parking. It can be concluded that biodegradation is the predominant natural attenuation mechanism for PAH degradation and crankcase oil loss in the covered parking structure. In open parking, however, natural attenuation processes are dominated by water-washing.
Near East: ICOMOS et le défi de la destruction à grande échelle du patrimoine culturel au Proche-Orient / The Future of Mosul Heritage after the Destruction / UNESCO Director-General Condemns Destruction at Nimrud / Syria Annual Report 2015 / War and Destruction in the Old City of Aleppo / For the Safeguarding and Preservation of the Cultural Sites in Syria – Memorandum of the German National Committee of ICOMOS
Creators: name: Hrsg., ICOMOS
name: Ministry Of Culture, Syrian Arab Republic
name: Abdulac, Samir
Publisher: name: Heritage at Risk
Year: 2018

description: Heritage at Risk, H@R 2014-2015
title: Cabo Verde e a graduação da lista de países menos avançados : da validação política à transição sustentável
Creators: name: Pais, Irina Luís
Publisher: name: Universidade Lusíada Editora
Year: 2012

description: Lusíada. Política internacional e segurança. - ISSN 1647-1342. - S. 1, n. 6-7 (2012). - p. 51-69.
Additional file 1 of Decreased ratios of matrix metalloproteinases to tissue-type inhibitors in cerebrospinal fluid in sporadic and hereditary cerebral amyloid angiopathy
Creators: name: Vervuurt, Marc
name: de Kort, Anna M.
name: Jäkel, Lieke
name: Kersten, Iris
name: Abdo, Wilson F.
name: Schreuder, Floris H. B. M.
name: Rasing, Ingeborg
name: Terwindt, Gisela M.
name: Wermer, Marieke J. H.
name: Greenberg, Steven M.
name: Klijn, Catharina J. M.
name: Kuiperij, H. Bea
name: Verbeek, Marcel M.
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Marine Biology
subject: Cancer
subject: Hematology

description: Additional file 1: Figs. A1 and A2.
Spätmittelalterliche „Komforen“ aus Emden und ihre niederländischen Parallelen
Creators: name: Stilke, Henning
name: Vilsteren, Vincent Van
Publisher: name: Nachrichten aus Niedersachsens Urgeschichte
Year: 2018

description: -
description: Nachrichten aus Niedersachsens Urgeschichte, Bd. 61 (1992): Nachrichten aus Niedersachsens Urgeschichte
Hans-Jürgen Hässler (Hrsg.), Ur- und Frühgeschichte in Niedersachsen
Creators: name: Wegner, Hans-H.
Publisher: name: Nachrichten aus Niedersachsens Urgeschichte
Year: 2018

description: Rezension zu: Hans-Jürgen Hässler (Hrsg.), Ur- und Frühgeschichte in Niedersachsen. Mit Beiträgen von Frank Berger, Hans- Jürgen Hässler, Elke Heege, Winfried Henke, Reinhard Maier, Klaus-Dieter Meyer, Alf Metzler, Jutta Möller, Wolfgang Schlüter, Wolfgang Schwarz, Ulrich Staesche, Hartmut Thieme, Brigitte Urban, Otto Mathias Wilbertz und Friedrich-Wilhelm Wulf. — Stuttgart: Konrad Theiss-Verlag 1991, 593 Seiten mit 345 Abbildungen und 24 Farbtafeln. 17,5 x 23,5 cm, gebunden mit Schutzumschlag. ISBN 3-8062-0495-0.
description: Nachrichten aus Niedersachsens Urgeschichte, Bd. 61 (1992): Nachrichten aus Niedersachsens Urgeschichte
Gerold Happ, Bestattungen und Menschenreste in „ Häusern “ und Siedlungen des steinzeitlichen Mitteleuropa
Creators: name: Heege, Elke
Publisher: name: Nachrichten aus Niedersachsens Urgeschichte
Year: 2018

description: Rezension zu: Gerold Happ, Bestattungen und Menschenreste in „ Häusern “ und Siedlungen des steinzeitlichen Mitteleuropa. — Europäische Hochschulschriften, Reihe 38 (Archäologie), Bd. 33. — Frankfurt — Bern — New York — Paris: Peter Lang Verlag 1991. VI und 433 Seiten, 58 Tabellen. ISBN 3-631-43344-1.
description: Nachrichten aus Niedersachsens Urgeschichte, Bd. 61 (1992): Nachrichten aus Niedersachsens Urgeschichte
Angular momentum transfer to a Milky Way disk at high redshift
Creators: name: Tillson, Henry
name: Devriendt, Julien
name: Slyz, Adrianne
name: Miller, Lance
name: Pichon, Christophe
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: An Adaptive Mesh Refinement cosmological resimulation is analyzed in order to test whether filamentary flows of cold gas are responsible for the build-up of angular momentum within a Milky Way like disk at z>=3. A set of algorithms is presented that takes advantage of the high spatial resolution of the simulation (12 pc) to identify: (i) the central gas disk and its plane of orientation; (ii) the complex individual filament trajectories that connect to the disk, and; (iii) the infalling satellites. The results show that two filaments at z>5.5, which later merge to form a single filament at z<4, drive the angular momentum and mass budget of the disk throughout its evolution, whereas luminous satellite mergers make negligible fractional contributions. Combined with the ubiquitous presence of such filaments in all large-scale cosmological simulations that include hydrodynamics, these findings provide strong quantitative evidence that the growth of thin disks in haloes with masses below 10^{12} M_{sun}, which host the vast majority of galaxies, is supported via inflowing streams of cold gas at intermediate and high redshifts.
description: Submitted to MNRAS, comments welcome. 17 pages (including appendices), 7 figures
Dietary lycopene is negatively associated with abdominal aortic calcification in US adults: a cross-sectional study
Creators: name: Hu, Lemei
name: Liu, Quanjun
name: Ou, Yunyao
name: Li, Dongdong
name: Wu, Yongdong
name: Li, Hengyi
name: Zhu, Zhigang
name: Liang, Ming
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Molecular Biology
Biotechnology
Cancer
Science Policy

description: Vascular calcification (VC) is one of the complications of chronic kidney disease (CKD) patients. Previous studies have confirmed that oxidative stress (OS) plays an important role in developing VC and that antioxidants have anti-VC effects. Our study aimed to determine the relationship between the intake of antioxidants from dietary sources and the prevalence of VC, especially in the CKD population. This cross-sectional study analyzed population-based data from the National Health and Nutrition Examination Survey (NHANES; 2013–2014). Participants were noninstitutionalized adults >40 years of age. Diet-derived antioxidants were obtained from the first 24-h dietary recall interviews. The abdominal aortic calcification (AAC) score was measured by a DXA scan. We divided the AAC scores into three groups: no calcification (AAC =0), mild to moderate calcification (0< AAC ≤6), and severe calcification (AAC >6). A total of 2897 participants were included in the main analysis. Our results showed that vitamin B6, α-tocopherol, and lycopene were associated with severe AAC in unadjusted models (odds ratio (OR): 0.81, 95% confidence interval (CI): 0.72–0.91, p = 0.001; OR: 0.97, 95% CI: 0.95–0.99, p = 0.008; OR: 0.98, 95% CI: 0.96–0.99, p = 0.01, respectively). However, only dietary lycopene was associated with severe AAC after adjusting covariates based on clinical and statistical significance. Per 1 mg higher intake of diet-derived lycopene per day, the odds of having severe AAC were 2% lower in the fully adjusted model (OR: 0.98, 95% CI: 0.95–0.999, p = 0.04). Moreover, in subgroup analysis, diet-derived antioxidant was not associated with AAC in patients with CKD. Our findings indicate that a higher intake of diet-derived lycopene was independently associated with lower odds of having severe AAC in humans. Therefore, a high intake of diet-derived lycopene may help prevent severe AAC. Dietary lycopene was inversely associated with vascular calcification (VC) in adults.Patients with chronic kidney disease (CKD) have a higher chance of having severe VC.Dietary antioxidants were not significantly associated with VC in patients with CKD. Dietary lycopene was inversely associated with vascular calcification (VC) in adults. Patients with chronic kidney disease (CKD) have a higher chance of having severe VC. Dietary antioxidants were not significantly associated with VC in patients with CKD.
Klaus Günther, Siedlung und Werkstätten von Feinschmieden der älteren Römischen Kaiserzeit bei Warburg-Daseburg
Creators: name: Zimmermann, Ulrich
Publisher: name: Nachrichten aus Niedersachsens Urgeschichte
Year: 2018

description: Rezension zu: Klaus Günther, Siedlung und Werkstätten von Feinschmieden der älteren Römischen Kaiserzeit bei Warburg-Daseburg. Mit Beiträgen von Klaus Hilpert, Axel Höhndorf, Dietrich Horstmann u. a. — Bodenaltertümer Westfalens, Band 24. Münster: Aschendorf Verlag 1990. 125 Seiten, 106 Abbildungen, 3 Tabellen und 5 lose Beilagen. ISBN 3-402-05137-0.
description: Nachrichten aus Niedersachsens Urgeschichte, Bd. 61 (1992): Nachrichten aus Niedersachsens Urgeschichte
Die Automatisierung der Bibliothek des Livingstone- Museums in Sambia – ein Erfahrungsbericht
Creators: name: Phiri, Fidelity
Publisher: name: AKMB-news: Informationen zu Kunst, Museum und Bibliothek
Year: 2018

description: -
description: AKMB-news: Informationen zu Kunst, Museum und Bibliothek, Bd. 23, Nr. 1 (2017): AKMB-news
Understanding Treatment-Seeking Decisions in Acute Stroke Survivors in Thailand
Creators: name: Potisopha, Wiphawadee
Publisher: name: University of Illinois at Chicago
Year: 2021
Subjects: Uncategorized

description: Background: Many Thai stroke patients are ineligible for reperfusion treatment due to prolonged prehospital delay. Decision delay mainly influences prehospital delay; yet, factors affecting this phase have not been fully explored. Despite the possibility of bystander’s involvement, prior studies have mostly excluded bystanders. Objectives: This study aimed to examine influencing factors of decision delay and to explore the impact of bystanders on treatment-seeking decisions after stroke symptoms. Methods: Based on Leventhal's Common-Sense Model, this cross-sectional correlational study recruited 170 acute stroke patients and 108 bystanders at three hospitals in Khon Kaen, Thailand. Patients and bystanders were interviewed using structural questionnaires with integrating open-ended and verbatim responses. The patient's clinical data were obtained from medical records. Data was analyzed by using descriptive statistics, content analysis, gamma regression, and logistic regression. Results: Treatment-seeking decisions in Thai acute stroke patients included 5 phases (pre-recognition, decision, waiting, transportation, and referral). The median prehospital delay and decision delay were 372 minutes and 120 minutes, respectively. Dyslipidemia, atrial fibrillation, and prior stroke knowledge influenced a short decision delay; whereas, the alternative behaviors of the bystanders and patients rather than seeking treatment were related to the prolonged decision delay. Of 170 patients, 41% had early decision (≤ 1 hour), and 42% had early prehospital time (≤ 4.5 hours). The primary decision-makers included the patients (29%), bystanders (49%), and joint decisions between them (22%), which were insignificantly related to both decision and prehospital delay times. The determinants of the bystanders as primary decision-makers were hemorrhagic stroke, speech problems, advanced age, and low prior stroke knowledge. As a parallel to the patients' factors, only the bystander's action was a strong predictor of a decision within 1 hour and prehospital delay within 4.5 hours. Conclusion: This study confirms decision delay as the primary contributor to prehospital delay and bystanders as the vital persons of treatment-seeking decisions for acute stroke patients. There is a need for a public stroke intervention addressing significant relatives as bystanders. Prospective research should be further conducted in high-risk stroke cases.
A stochastic algorithm finding $p$-means on the circle
Creators: name: Arnaudon, Marc
name: Miclo, Laurent
Publisher: name: arXiv
Year: 2013
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: A stochastic algorithm is proposed, finding some elements from the set of intrinsic $p$-mean(s) associated to a probability measure $ν$ on a compact Riemannian manifold and to $p\in[1,\infty)$. It is fed sequentially with independent random variables $(Y_n)_{n\in \mathbb{N}}$ distributed according to $ν$, which is often the only available knowledge of $ν$. Furthermore, the algorithm is easy to implement, because it evolves like a Brownian motion between the random times when it jumps in direction of one of the $Y_n$, $n\in\mathbb{N}$. Its principle is based on simulated annealing and homogenization, so that temperature and approximations schemes must be tuned up (plus a regularizing scheme if $ν$ does not admit a Hölderian density). The analysis of the convergence is restricted to the case where the state space is a circle. In its principle, the proof relies on the investigation of the evolution of a time-inhomogeneous $\mathbb{L}^2$ functional and on the corresponding spectral gap estimates due to Holley, Kusuoka and Stroock. But it requires new estimates on the discrepancies between the unknown instantaneous invariant measures and some convenient Gibbs measures.
description: Published at http://dx.doi.org/10.3150/15-BEJ728 in the Bernoulli (http://isi.cbs.nl/bernoulli/) by the International Statistical Institute/Bernoulli Society (http://isi.cbs.nl/BS/bshome.htm)
Die Zukunft in Kunst- und Museumsbibliotheken: Digitale Wissensräume – extended. Herbstfortbildung der AKMB im LWL – Museum für Kunst und Kultur, Westfälisches Landesmuseum Münster, 17./18. November 2016
Creators: name: Fernengel, Birgit
Publisher: name: AKMB-news: Informationen zu Kunst, Museum und Bibliothek
Year: 2018

description: -
description: AKMB-news: Informationen zu Kunst, Museum und Bibliothek, Bd. 23, Nr. 1 (2017): AKMB-news
Quantitative connection between the nanoscale electronic inhomogeneity and the pseudogap of Bi$_2$Sr$_2$CaCu$_2$O$_{8+δ}$ superconductors
Creators: name: Honma, Tatsuya
name: Hor, Pei-Herng
Publisher: name: arXiv
Year: 2013
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We have found a quantitative connection between the evolution of the inhomogeneous nanoscale electronic gaps (INSEG) state detected in Bi$_2$Sr$_2$CaCu$_2$O$_{8+δ}$ by scanning tunneling microscopy/spectroscopy (STM/S) and the two universal, the upper and the lower, pseudogaps in high-temperature cuprate superconductors (HTCS). When the doping and temperature dependent INSEG map were analyzed by using our proposed hole-scale, we find that the two pseudogaps are connected to two specific coverages of the CuO$_2$ plane by INSEG: the 50\% and 100\% coverages of the CuO$_2$ planes by INSEG correspond to the upper and lower pseudogaps, respectively. This quantitative connection to the two pseudogaps indicates that the origin of the measured pseudogap energies and temperatures are intimately related to the geometrical coverage of the CuO$_2$ planes by the INSEG state. We find that INSEG and superconductivity coexist in the underdoped to the overdoped regimes. We suggest that pseudogap states are microscopically inhomogeneous and 100\% coverage of the CuO$_2$ planes by the INSEG is a necessary condition for the high-$T_c$ superconductivity.
description: 15 pages and 4 figures. Many parts, which were deleted from the submission of version 4, will be appear in the next paper (Proceedings of the NEW3-SC10)
Museumspolitik als Kulturpolitik
Creators: name: Heitbrink, Matthias
Publisher: name: AKMB-news: Informationen zu Kunst, Museum und Bibliothek
Year: 2018

description: Rezension zu: Museen im Nationalsozialismus. Akteure, Orte,
Politik / hrsg. von Tanja Baensch, Kristina Kratz-
Kessemeier, Dorothee Wimmer. – Köln u. a. :
Böhlau, 2016. – 411 Seiten : Illustrationen. – (Veröffentlichungen
der Richard-Schöne-Gesellschaft
für Museumsgeschichte e. V.) – ISBN 978-3-412-
22408-0.
description: AKMB-news: Informationen zu Kunst, Museum und Bibliothek, Bd. 23, Nr. 1 (2017): AKMB-news
Flexible Value Encoding by Ventral Tegmental Area Dopamine Neurons
Creators: name: Hurh, Samantha Joann
Publisher: name: University of Illinois at Chicago
Year: 2021
Subjects: Uncategorized

description: The ability to flexibly encode the value of environmental stimuli is crucial for survival. Dopamine’s role in reward has been well-established, but its role in the encoding of aversion remains controversial. Currently, there are discrepancies in the methodological approaches used to study aversion. Aversive stimuli can oftentimes be avoided by animals making it difficult to measure responses accurately and consistently. To circumvent this issue, we used intra-oral catheters and in vivo fiber photometry in the ventral tegmental area (VTA) to measure dopamine activity following unavoidable, intra-oral delivery of taste stimuli. Infusions of a rewarding solution (0.3 M sucrose) briefly elevated, while infusions of an aversive solution (0.001 M quinine) briefly suppressed VTA dopamine activity. Next, to address whether value encoding changes as a function of experience, a conditioned taste aversion (CTA) paradigm was used where one group (Paired; n = 8) of animals received one visceral malaise inducing injection of lithium chloride (LiCl) while another group (Unpaired; n = 7) received a saline injection. As in the first experiment, VTA dopamine activity was measured in vivo in response to intra-oral sucrose on Conditioning Day and five successive extinction days. In addition, animals were subjected to a two-bottle sucrose preference test (SPT) following each extinction session to assay avoidance behavior. Our results demonstrate that VTA dopamine signaling in Paired animals was significantly suppressed relative to Unpaired on extinctions days 1 and 2. Moreover, CTA and SPT data revealed that Paired animals consumed less sucrose on extinction days 1 and 2, relative to Unpaired. Taken together, we show that VTA dopamine neurons can flexibly encode the value of taste stimuli as a function of experience.
Odd parity pairing and nodeless anti-phase $s^\pm$ in Iron-Based Superconductors
Creators: name: Hao, Ningning
name: Hu, Jiangping
Publisher: name: arXiv
Year: 2013
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We discuss the sign change of superconducting order parameters in both real and reciprocal spaces when the odd parity spin singlet pairing proposed recently in\cite{huoddparity} is allowed. We show that in this case an nodeless anti-phase $s^\pm$ can be generated. In a 2-Fe Brilliouin zone (BZ), sign change exists between two hole pockets and between two electron pockets. In a 1-Fe BZ which includes two 2-Fe BZs, the sign change is between two 2-Fe BZs, which leads to a d-wave type sign distribution on the electron pockets, namely, an anti-phase $s^\pm$ state with no symmetry protected gapless node on the electron pockets. This sign change character consistently explains experimental results related to sign change properties measured on both iron-pnictides and iron-chalcogenides.
description: 3 figures 5 pages
Erste Ergebnisse der Restaurierung von Funden aus dem Fürstengrab von Kappel a. Rhein, Ortenaukreis
Creators: name: Dehn, Rolf
Publisher: name: Archäologische Nachrichten aus Baden
Year: 2018

description: -
description: Archäologische Nachrichten aus Baden, Bd. 23 (1979): Archäologische Nachrichten aus Baden
Editorial
Creators: name: Demont, Paul
name: Dillery, John
name: Gazzano, Francesca
name: Harrison, Thomas
name: Haywood, Jan
name: Irwin, Elizabeth
name: Low, Polly
name: Schwab, Andreas
name: Vannicelli, Pietro
Publisher: name: Syllogos - Herodotus Journal
Year: 2023

description: Syllogos - Herodotus Journal, Vol. 2 (2023)
Additional file 1 of Evaluation of in silico pathogenicity prediction tools for the classification of small in-frame indels
Creators: name: Cannon, S.
name: Williams, M.
name: Gunning, A. C.
name: Wright, C. F.
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file 1: Fig. S1. ROC curves and AUCs using (A) 3964 in-frame indels from gnomAD, ClinVar and the DDD study (B) 151 in-frame indels only observed in the DDD study. Only tools producing continuous data as output are plotted (n=7). Fig. S2. Performance of nine pathogenicity prediction tools versus increasing variant length in a dataset of 3964 in-frame indels aggregated from gnomAD, ClinVar and the DDD study. Fig. S3. Sensitivity and specificity of 9 pathogenicity prediction algorithms with increasing variant length in a dataset of in-frame (A) deletions (n=2718) and (B) insertions (n=1246).