title: ÐÐ°Ð³Ð½Ð¸ÑÐ½Ð¾-ÑÐµÐ·Ð¾Ð½Ð°Ð½ÑÐ½Ð°Ñ Ð¼Ð¾ÑÑÐ¾Ð¼ÐµÑÑÐ¸Ñ Ð² Ð¾ÑÐµÐ½ÐºÐµ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ð¹ Ð³Ð¾Ð»Ð¾Ð²Ð½Ð¾Ð³Ð¾ Ð¼Ð¾Ð·Ð³Ð° Ñ Ð±Ð¾Ð»ÑÐ½ÑÑ ÑÐ°ÑÑÐµÑÐ½Ð½ÑÐ¼ ÑÐºÐ»ÐµÑÐ¾Ð·Ð¾Ð¼
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Magnetic resonance morphometry in the assessment of brain changes in patients with multiple sclerosis
Creators: name: ÐÐ°Ð¹Ð´Ð°Ð¼Ð¾Ð²Ð¸Ñ, ÐÐ»ÐµÐºÑÐ°Ð½Ð´ÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: ÑÐ°ÑÑÐµÑÐ½Ð½ÑÐ¹ ÑÐºÐ»ÐµÑÐ¾Ð·
Ð¿Ð¾ÑÑÐ¾Ð±ÑÐ°Ð±Ð¾ÑÐºÐ°
Ð³ÑÑÐ¿Ð¿Ð¾Ð²Ð¾Ð¹ Ð°Ð½Ð°Ð»Ð¸Ð· Ð² freesurfer
ÑÑÐ°Ð½ÑÐ¿Ð»Ð°Ð½ÑÐ°ÑÐ¸Ñ ÑÑÐ²Ð¾Ð»Ð¾Ð²ÑÑ ÐºÐ»ÐµÑÐ¾Ðº
ÐºÐ¾ÑÐ° Ð³Ð¾Ð»Ð¾Ð²Ð½Ð¾Ð³Ð¾ Ð¼Ð¾Ð·Ð³Ð°
ÐÐ Ð¼Ð¾ÑÑÐ¾Ð¼ÐµÑÑÐ¸Ñ
multiple sclerosis
post-processing
group analysis in freesurfer
stem cell transplantation
cerebral cortex
mr morphometry

description: ÐÐ  Ð¼Ð¾ÑÑÐ¾Ð¼ÐµÑÑÐ¸Ñ Ð¿Ð¾Ð·Ð²Ð¾Ð»ÑÐµÑ Ð¾ÑÐµÐ½Ð¸Ð²Ð°ÑÑ Ð½ÐµÐ¹ÑÐ¾Ð´ÐµÐ³ÐµÐ½ÐµÑÐ°ÑÐ¸Ð²Ð½ÑÐ¹ ÐºÐ¾Ð¼Ð¿Ð¾Ð½ÐµÐ½Ñ Ñ Ð±Ð¾Ð»ÑÐ½ÑÑ ÑÐ°ÑÑÐµÑÐ½Ð½ÑÐ¼ ÑÐºÐ»ÐµÑÐ¾Ð·Ð¾Ð¼. Ð£ÑÐµÐ½ÑÐ¼Ð¸ Ð²ÑÑÑÐ½ÐµÐ½Ð¾, ÑÑÐ¾ Ð°ÑÑÐ¾ÑÐ¸Ñ Ð³Ð¾Ð»Ð¾Ð²Ð½Ð¾Ð³Ð¾ Ð¼Ð¾Ð·Ð³Ð° Ð½Ð°ÑÐ¸Ð½Ð°ÐµÑÑÑ Ð½Ð° ÑÐ°Ð¼ÑÑ ÑÐ°Ð½Ð½Ð¸Ñ ÑÑÐ°Ð´Ð¸ÑÑ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ñ, Ð¿ÑÐ¸ ÑÑÐ¾Ð¼ Ð¾ÑÐ¼ÐµÑÐµÐ½Ð¾, ÑÑÐ¾ Ð°ÑÑÐ¾ÑÐ¸Ñ ÑÐµÑÐ¾Ð³Ð¾ Ð²ÐµÑÐµÑÑÐ²Ð° Ð²ÑÑÐ°Ð¶ÐµÐ½Ð° Ð±Ð¾Ð»ÑÑÐµ, ÑÐµÐ¼ Ð±ÐµÐ»Ð¾Ð³Ð¾. Ð¦ÐµÐ»ÑÑ Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ Ð±ÑÐ»Ð¾ Ð¾ÑÐµÐ½Ð¸ÑÑ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ ÐºÐ¾ÑÐºÐ¾Ð²ÑÑ ÑÑÑÑÐºÑÑÑ Ñ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ñ ÑÐ°ÑÑÐµÑÐ½Ð½ÑÐ¼ ÑÐºÐ»ÐµÑÐ¾Ð·Ð¾Ð¼ Ð² ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ Ð²Ð°ÑÐ¸Ð°Ð½ÑÐ°Ñ ÐµÐ³Ð¾ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ, Ð° ÑÐ°ÐºÐ¶Ðµ Ð¿ÑÐ¾Ð²ÐµÑÑÐ¸ ÐºÐ¾ÑÑÐµÐ»ÑÑÐ¸Ð¾Ð½Ð½ÑÐ¹ Ð°Ð½Ð°Ð»Ð¸Ð· Ð´Ð¸Ð½Ð°Ð¼Ð¸ÐºÐ¸ ÐÐ  Ð¼Ð¾ÑÑÐ¾Ð¼ÐµÑÑÐ¸Ð¸ Ð¾ÑÐ´ÐµÐ»ÑÐ½Ð¾Ð¹ Ð³ÑÑÐ¿Ð¿Ñ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð², Ð¿ÑÐ¾-ÑÐ¾Ð´Ð¸Ð²ÑÐ¸Ñ Ð»ÐµÑÐµÐ½Ð¸Ðµ ÑÑÐ²Ð¾Ð»Ð¾Ð²ÑÐ¼Ð¸ ÐºÐ»ÐµÑÐºÐ°Ð¼Ð¸. Ð ÑÐ°Ð±Ð¾ÑÐµ Ð±ÑÐ»Ð¸ Ð¿Ð¾Ð»ÑÑÐµÐ½Ñ ÐÐ  Ð¢2-Ð²Ð·Ð²ÐµÑÐµÐ½Ð½ÑÐµ Ð¸Ð·Ð¾Ð±ÑÐ°Ð¶ÐµÐ½Ð¸Ñ 43 Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð², Ð´Ð»Ñ Ð½Ð¸Ñ Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸Ð»ÑÑ Ð¼Ð¾ÑÑÐ¾Ð¼ÐµÑÑÐ¸ÑÐµÑÐºÐ¸Ð¹ Ð°Ð½Ð°Ð»Ð¸Ð· ÐºÐ¾ÑÑ ÐÐ. ÐÑÐµ Ð°Ð½Ð°Ð»Ð¸Ð·Ñ Ð¸ Ð²Ð¸Ð·ÑÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸Ð»Ð¸ÑÑ Ñ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½ÑÐ¼ Ð¿Ð°ÐºÐµÑÐ¾Ð¼ FreeSurfer Ð² Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÐ¸ Ð¾Ñ Ð¿ÑÐ¾Ð³ÑÐµÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð±Ð¾Ð»ÐµÐ·Ð½Ð¸, ÑÑÐµÐ¿ÐµÐ½Ð¸ Ð¸Ð½Ð²Ð°Ð»Ð¸Ð´Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð², Ð¸Ñ Ð²Ð¾Ð·ÑÐ°ÑÑÐ°, Ð° ÑÐ°ÐºÐ¶Ðµ ÑÐ¸Ð¿Ð° ÑÐµÑÐµÐ½Ð¸Ñ Ð±Ð¾Ð»ÐµÐ·Ð½Ð¸. ÐÐ»Ñ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð², Ð¿ÑÐ¾ÑÐµÐ´ÑÐ¸Ñ ÑÑÐ°Ð½ÑÐ¿Ð»Ð°Ð½ÑÐ°ÑÐ¸Ñ ÑÑÐ²Ð¾Ð»Ð¾Ð²ÑÑ ÐºÐ»ÐµÑÐ¾Ðº, Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ ÐºÐ¾ÑÑ Ð½Ðµ Ð¾Ð±Ð½Ð°ÑÑÐ¶ÐµÐ½Ñ. Ð­ÑÐ¾ Ð¼Ð¾Ð¶ÐµÑ Ð±ÑÑÑ Ð¾Ð±ÑÑÑÐ½ÐµÐ½Ð¾ ÑÐµÐ¼, ÑÑÐ¾ Ð¿ÑÐ¾ÑÐµÑÑ Ð½ÐµÐ¹ÑÐ¾Ð´ÐµÐ³ÐµÐ½ÐµÑÐ°ÑÐ¸Ð¸ Ð¼Ð¾Ð¶ÐµÑ Ð¿ÑÐ¾Ð´Ð¾Ð»Ð¶Ð°ÑÑÑÑ Ð´Ð¾ Ð´Ð²ÑÑ Ð»ÐµÑ Ð¿Ð¾ÑÐ»Ðµ Ð½Ð°ÑÐ°Ð»Ð° ÑÐµÑÐ°Ð¿Ð¸Ð¸ Ñ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸ÐµÐ¼ Ð¢Ð¡Ð. Ð­ÑÐ¾ ÑÐºÐ°Ð·ÑÐ²Ð°ÐµÑ Ð½Ð° Ð½ÐµÐ¾Ð±ÑÐ¾Ð´Ð¸Ð¼Ð¾ÑÑÑ Ð´Ð°Ð»ÑÐ½ÐµÐ¹ÑÐµÐ³Ð¾ Ð´Ð¸Ð½Ð°Ð¼Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÐÐ  Ð¼Ð¾ÑÑÐ¾Ð¼ÐµÑÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÐºÐ¾Ð½ÑÑÐ¾Ð»Ñ ÐºÐ¾ÑÑ ÐÐ ÑÐ°ÐºÐ¸Ñ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð². ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¿Ð¾ÐºÐ°Ð·ÑÐ²Ð°ÑÑ, ÑÑÐ¾ ÑÐ¶Ðµ Ð½Ð° Ð½Ð°ÑÐ°Ð»ÑÐ½ÑÑ ÑÑÐ°Ð´Ð¸ÑÑ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ñ Ð¿ÑÐ¾ÑÐ²Ð»ÑÐµÑÑÑ Ð¿Ð°ÑÐ¾Ð»Ð¾Ð³Ð¸Ñ ÐºÐ¾ÑÑ ÐÐ, Ð¸ Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ Ð¼ÐµÑÐ¾Ð´Ð¸ÐºÐ¸ ÐÐ  Ð¼Ð¾ÑÑÐ¾Ð¼ÐµÑÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð¼Ð¾Ð¶Ð½Ð¾ Ð¿ÑÐ¾Ð³Ð½Ð¾Ð·Ð¸ÑÐ¾Ð²Ð°ÑÑ Ð´Ð°Ð»ÑÐ½ÐµÐ¹ÑÐµÐµ Ð¿ÑÐ¾ÑÐµÐºÐ°Ð½Ð¸Ðµ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ñ Ð¸ ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²ÐµÐ½Ð½Ð¾ Ð¿Ð¾Ð´Ð±Ð¸ÑÐ°ÑÑ Ð±Ð¾Ð»ÐµÐµ ÑÐ¾ÑÐ½ÑÐµ Ð¼ÐµÑÐ¾Ð´Ñ Ð»ÐµÑÐµÐ½Ð¸Ñ.
description: Magnetic resonance morphometry makes it possible to evaluate the neurodegenerative component in patients with multiple sclerosis. Scientists have found that atrophy of the brain begins at the very early stages of the disease, while it was noted that atrophy of the gray matter more pronounced than atrophy of the white matter. The aim of this work was to evaluate changes in cortical structures in patients with multiple sclerosis in various variants of its development, as well as to conduct a correlation analysis of the dynamics of MR morphometry of a particular group of patients treated with stem cells. In this work, there were obtained magnetic resonance T2 weighted images of 43 patients with multiple sclerosis. After that there was made a morphometric analysis of the cerebral cortex for them. All analyzes and visualizations were carried out with the FreeSurfer software package depending on the progression of the disease, the degree of disability of patients, their age, as well as the type of course of the disease. For patients who underwent stem cell transplantation, changes in the cortex were not detected. This can be explained by the fact that the process of neurodegeneration can continue up to two years after the start of therapy with the use of TSC. This indicates the need for further dynamic MR morphometric control of the cortex in such patients. The results obtained show that already at the initial stages of the disease, the pathology of the cortex is manifested, and using the method of MR morphometric analysis, it is possible to predict the further course of the disease and, accordingly, select more accurate treatment methods.