Pathway and network analysis of more than 2500 whole cancer genomes
Creators: name: Reyna, Matthew A
name: Haan, David
name: Paczkowska, Marta
name: Verbeke, Lieven PC
name: Vazquez, Miguel
name: Kahraman, Abdullah
name: Pulido-Tamayo, Sergio
name: Barenboim, Jonathan
name: Wadi, Lina
name: Dhingra, Priyanka
name: Shrestha, Raunak
name: Getz, Gad
name: Lawrence, Michael S
name: Pedersen, Jakob Skou
name: Rubin, Mark A
name: Wheeler, David A
name: Brunak, Søren
name: Izarzugaza, Jose MG
name: Khurana, Ekta
name: Marchal, Kathleen
name: von Mering, Christian
name: Sahinalp, S Cenk
name: Valencia, Alfonso
name: Abascal, Federico
name: Amin, Samirkumar B
name: Bader, Gary D
name: Bandopadhayay, Pratiti
name: Beroukhim, Rameen
name: Bertl, Johanna
name: Boroevich, Keith A
name: Busanovich, John
name: Campbell, Peter J
name: Carlevaro-Fita, Joana
name: Chakravarty, Dimple
name: Chan, Calvin Wing Yiu
name: Chen, Ken
name: Choi, Jung Kyoon
name: Deu-Pons, Jordi
name: Diamanti, Klev
name: Feuerbach, Lars
name: Fink, J Lynn
name: Fonseca, Nuno A
name: Frigola, Joan
name: Gambacorti-Passerini, Carlo
name: Garsed, Dale W
name: Gerstein, Mark
name: Guo, Qianyun
name: Gut, Ivo G
name: Hamilton, Mark P
name: Haradhvala, Nicholas J
name: Harmanci, Arif O
name: Helmy, Mohamed
name: Herrmann, Carl
name: Hess, Julian M
name: Hobolth, Asger
name: Hodzic, Ermin
name: Hong, Chen
name: Hornshøj, Henrik
name: Isaev, Keren
name: Johnson, Rory
name: Johnson, Todd A
name: Juul, Malene
name: Juul, Randi Istrup
name: Kahles, Andre
name: Kellis, Manolis
name: Kim, Jaegil
name: Kim, Jong K
name: Kim, Youngwook
name: Komorowski, Jan
name: Korbel, Jan O
name: Kumar, Sushant
name: Lanzós, Andrés
name: Larsson, Erik
name: Lee, Donghoon
name: Lehmann, Kjong-Van
name: Li, Shantao
name: Li, Xiaotong
name: Lin, Ziao
name: Liu, Eric Minwei
name: Lochovsky, Lucas
name: Lou, Shaoke
name: Madsen, Tobias
name: Martincorena, Iñigo
name: Martinez-Fundichely, Alexander
name: Maruvka, Yosef E
name: McGillivray, Patrick D
name: Meyerson, William
name: Muiños, Ferran
name: Mularoni, Loris
name: Nakagawa, Hidewaki
name: Nielsen, Morten Muhlig
name: Park, Keunchil
name: Park, Kiejung
name: Pons, Tirso
name: Reyes-Salazar, Iker
name: Rheinbay, Esther
name: Rubio-Perez, Carlota
name: Saksena, Gordon
name: Salichos, Leonidas
name: Sander, Chris
name: Schumacher, Steven E
name: Shackleton, Mark
name: Shapira, Ofer
name: Shen, Ciyue
name: Shuai, Shimin
name: Sidiropoulos, Nikos
name: Sieverling, Lina
name: Sinnott-Armstrong, Nasa
name: Stein, Lincoln D
name: Tamborero, David
name: Tiao, Grace
name: Tsunoda, Tatsuhiko
name: Umer, Husen M
name: Uusküla-Reimand, Liis
name: Wadelius, Claes
name: Wang, Jiayin
name: Warrell, Jonathan
name: Waszak, Sebastian M
name: Weischenfeldt, Joachim
name: Wu, Guanming
name: Yu, Jun
name: Zhang, Jing
name: Zhang, Xuanping
name: Zhang, Yan
name: Zhao, Zhongming
name: Zou, Lihua
name: Reimand, Jüri
name: Stuart, Joshua M
name: Raphael, Benjamin J
name: Aaltonen, Lauri A
name: Abeshouse, Adam
name: Aburatani, Hiroyuki
name: Adams, David J
name: Agrawal, Nishant
name: Ahn, Keun Soo
name: Ahn, Sung-Min
name: Aikata, Hiroshi
name: Akbani, Rehan
name: Akdemir, Kadir C
name: Al-Ahmadie, Hikmat
name: Al-Sedairy, Sultan T
name: Al-Shahrour, Fatima
name: Alawi, Malik
name: Albert, Monique
name: Aldape, Kenneth
name: Alexandrov, Ludmil B
name: Ally, Adrian
name: Alsop, Kathryn
name: Alvarez, Eva G
name: Amary, Fernanda
name: Aminou, Brice
name: Ammerpohl, Ole
name: Anderson, Matthew J
name: Ang, Yeng
name: Antonello, Davide
name: Anur, Pavana
name: Aparicio, Samuel
name: Appelbaum, Elizabeth L
name: Arai, Yasuhito
name: Aretz, Axel
name: Arihiro, Koji
name: Ariizumi, Shun-ichi
name: Armenia, Joshua
name: Arnould, Laurent
name: Asa, Sylvia
name: Assenov, Yassen
name: Atwal, Gurnit
name: Aukema, Sietse
name: Auman, J Todd
name: Aure, Miriam RR
name: Awadalla, Philip
name: Aymerich, Marta
name: Baez-Ortega, Adrian
name: Bailey, Matthew H
name: Bailey, Peter J
name: Balasundaram, Miruna
name: Balu, Saianand
name: Banks, Rosamonde E
name: Barbi, Stefano
name: Barbour, Andrew P
name: Barnholtz-Sloan, Jill
name: Barr, Hugh
name: Barrera, Elisabet
name: Bartlett, John
name: Bartolome, Javier
name: Bassi, Claudio
name: Bathe, Oliver F
name: Baumhoer, Daniel
name: Bavi, Prashant
name: Baylin, Stephen B
name: Bazant, Wojciech
name: Beardsmore, Duncan
name: Beck, Timothy A
name: Behjati, Sam
name: Behren, Andreas
name: Niu, Beifang
name: Bell, Cindy
name: Beltran, Sergi
name: Benz, Christopher
name: Berchuck, Andrew
name: Bergmann, Anke K
name: Bergstrom, Erik N
name: Berman, Benjamin P
name: Berney, Daniel M
name: Bernhart, Stephan H
name: Berrios, Mario
name: Bersani, Samantha
name: Betancourt, Miguel
name: Bhandari, Vinayak
name: Bhosle, Shriram G
name: Biankin, Andrew V
name: Bieg, Matthias
name: Bigner, Darell
name: Binder, Hans
name: Birney, Ewan
name: Birrer, Michael
name: Biswas, Nidhan K
name: Bjerkehagen, Bodil
name: Bodenheimer, Tom
name: Boice, Lori
name: Bonizzato, Giada
name: De Bono, Johann S
name: Boot, Arnoud
name: Bootwalla, Moiz S
name: Borg, Ake
name: Borkhardt, Arndt
name: Borozan, Ivan
name: Borst, Christoph
name: Bosenberg, Marcus
name: Bosio, Mattia
name: Boultwood, Jacqueline
name: Bourque, Guillaume
name: Boutros, Paul C
name: Bova, G Steven
name: Bowen, David T
name: Bowlby, Reanne
name: Bowtell, David DL
name: Boyault, Sandrine
name: Boyce, Rich
name: Boyd, Jeffrey
name: Brazma, Alvis
name: Brennan, Paul
name: Brewer, Daniel S
name: Brinkman, Arie B
name: Bristow, Robert G
name: Broaddus, Russell R
name: Brock, Jane E
name: Brock, Malcolm
name: Broeks, Annegien
name: Brooks, Angela N
name: Brooks, Denise
name: Brors, Benedikt
name: Bruxner, Timothy JC
name: Bruzos, Alicia L
name: Buchanan, Alex
name: Buchhalter, Ivo
name: Buchholz, Christiane
name: Bullman, Susan
name: Burke, Hazel
name: Burkhardt, Birgit
name: Burns, Kathleen H
name: Bustamante, Carlos D
name: Butler, Adam P
name: Butte, Atul J
name: Byrne, Niall J
name: Børresen-Dale, Anne-Lise
name: Caesar-Johnson, Samantha J
name: Cafferkey, Andy
name: Cahill, Declan
name: Calabrese, Claudia
name: Caldas, Carlos
name: Calvo, Fabien
name: Camacho, Niedzica
name: Campo, Elias
name: Cantù, Cinzia
name: Cao, Shaolong
name: Carey, Thomas E
name: Carlsen, Rebecca
name: Cataldo, Ivana
name: Cazzola, Mario
name: Cebon, Jonathan
name: Cerfolio, Robert
name: Chadwick, Dianne E
name: Chalmers, Don
name: Chan, Kin
name: Chan-Seng-Yue, Michelle
name: Chandan, Vishal S
name: Chang, David K
name: Chanock, Stephen J
name: Chantrill, Lorraine A
name: Chateigner, Aurélien
name: Chatterjee, Nilanjan
name: Chayama, Kazuaki
name: Chen, Hsiao-Wei
name: Chen, Jieming
name: Chen, Yiwen
name: Chen, Zhaohong
name: Cherniack, Andrew D
name: Chien, Jeremy
name: Chiew, Yoke-Eng
name: Chin, Suet-Feung
name: Cho, Juok
name: Cho, Sunghoon
name: Choi, Wan
name: Chomienne, Christine
name: Chong, Zechen
name: Choo, Su Pin
name: Chou, Angela
name: Christ, Angelika N
name: Christie, Elizabeth L
name: Chuah, Eric
name: Cibulskis, Carrie
name: Cibulskis, Kristian
name: Cingarlini, Sara
name: Clapham, Peter
name: Claviez, Alexander
name: Cleary, Sean
name: Cloonan, Nicole
name: Cmero, Marek
name: Collins, Colin C
name: Connor, Ashton A
name: Cooke, Susanna L
name: Cooper, Colin S
name: Cope, Leslie
name: Corbo, Vincenzo
name: Cordes, Matthew G
name: Cordner, Stephen M
name: Cortés-Ciriano, Isidro
name: Covington, Kyle
name: Cowin, Prue A
name: Craft, Brian
name: Craft, David
name: Creighton, Chad J
name: Cun, Yupeng
name: Curley, Erin
name: Cutcutache, Ioana
name: Czajka, Karolina
name: Czerniak, Bogdan
name: Dagg, Rebecca A
name: Danilova, Ludmila
name: Davi, Maria Vittoria
name: Davidson, Natalie R
name: Davies, Helen
name: Davis, Ian J
name: Davis-Dusenbery, Brandi N
name: Dawson, Kevin J
name: De La Vega, Francisco M
name: De Paoli-Iseppi, Ricardo
name: Defreitas, Timothy
name: Dei Tos, Angelo P
name: Delaneau, Olivier
name: Demchok, John A
name: Demeulemeester, Jonas
name: Demidov, German M
name: Demircioğlu, Deniz
name: Dennis, Nening M
name: Denroche, Robert E
name: Dentro, Stefan C
name: Desai, Nikita
name: Deshpande, Vikram
name: Deshwar, Amit G
name: Desmedt, Christine
name: Dhalla, Noreen
name: Dhani, Neesha C
name: Dhir, Rajiv
name: DiBiase, Anthony
name: Ding, Li
name: Ding, Shuai
name: Dinh, Huy Q
name: Dirix, Luc
name: Doddapaneni, HarshaVardhan
name: Donmez, Nilgun
name: Dow, Michelle T
name: Drapkin, Ronny
name: Drechsel, Oliver
name: Drews, Ruben M
name: Serge, Serge
name: Dudderidge, Tim
name: Dueso-Barroso, Ana
name: Dunford, Andrew J
name: Dunn, Michael
name: Dursi, Lewis Jonathan
name: Duthie, Fraser R
name: Dutton-Regester, Ken
name: Eagles, Jenna
name: Easton, Douglas F
name: Edmonds, Stuart
name: Edwards, Paul A
name: Edwards, Sandra E
name: Eeles, Rosalind A
name: Ehinger, Anna
name: Eils, Juergen
name: Eils, Roland
name: El-Naggar, Adel
name: Eldridge, Matthew
name: Ellrott, Kyle
name: Erkek, Serap
name: Escaramis, Georgia
name: Espiritu, Shadrielle MG
name: Estivill, Xavier
name: Etemadmoghadam, Dariush
name: Eyfjord, Jorunn E
name: Faltas, Bishoy M
name: Fan, Daiming
name: Fan, Yu
name: Faquin, William C
name: Farcas, Claudiu
name: Fassan, Matteo
name: Fatima, Aquila
name: Favero, Francesco
name: Fayzullaev, Nodirjon
name: Felau, Ina
name: Fereday, Sian
name: Ferguson, Martin L
name: Ferretti, Vincent
name: Field, Matthew A
name: Finocchiaro, Gaetano
name: Fisher, Cyril
name: Fittall, Matthew W
name: Fitzgerald, Anna
name: Fitzgerald, Rebecca C
name: Flanagan, Adrienne M
name: Fleshner, Neil E
name: Flicek, Paul
name: Foekens, John A
name: Fong, Kwun M
name: Foster, Christopher S
name: Fox, Natalie S
name: Fraser, Michael
name: Frazer, Scott
name: Frenkel-Morgenstern, Milana
name: Friedman, William
name: Fronick, Catrina C
name: Fujimoto, Akihiro
name: Fujita, Masashi
name: Fukayama, Masashi
name: Fulton, Lucinda A
name: Fulton, Robert S
name: Furuta, Mayuko
name: Futreal, P Andrew
name: Füllgrabe, Anja
name: Gabriel, Stacey B
name: Gallinger, Steven
name: Gao, Jianjiong
name: Gao, Shengjie
name: Garraway, Levi
name: Garred, Øystein
name: Garrison, Erik
name: Gehlenborg, Nils
name: Gelpi, Josep LL
name: George, Joshy
name: Gerhard, Daniela S
name: Gerhauser, Clarissa
name: Gershenwald, Jeffrey E
name: Gerstung, Moritz
name: Ghori, Mohammed
name: Ghossein, Ronald
name: Giama, Nasra H
name: Gibbs, Richard A
name: Gibson, Bob
name: Gill, Anthony J
name: Gill, Pelvender
name: Giri, Dilip D
name: Glodzik, Dominik
name: Gnanapragasam, Vincent J
name: Goebler, Maria Elisabeth
name: Goldman, Mary J
name: Gomez, Carmen
name: Gonzalez, Santiago
name: Gonzalez-Perez, Abel
name: Gordenin, Dmitry A
name: Gossage, James
name: Gotoh, Kunihito
name: Govindan, Ramaswamy
name: Grabau, Dorthe
name: Graham, Janet S
name: Grant, Robert C
name: Green, Anthony R
name: Green, Eric
name: Greger, Liliana
name: Grehan, Nicola
name: Grimaldi, Sonia
name: Grimmond, Sean M
name: Grossman, Robert L
name: Grundhoff, Adam
name: Gundem, Gunes
name: Gupta, Manaswi
name: Gupta, Shailja
name: Gut, Marta
name: Göke, Jonathan
name: Ha, Gavin
name: Haake, Andrea
name: Haas, Siegfried
name: Haase, Kerstin
name: Haber, James E
name: Habermann, Nina
name: Hach, Faraz
name: Haider, Syed
name: Hama, Natsuko
name: Hamdy, Freddie C
name: Hamilton, Anne
name: Han, Leng
name: Hanna, George B
name: Hansmann, Martin
name: Harismendy, Olivier
name: Harliwong, Ivon
name: Harrington, Eoghan
name: Hasegawa, Takanori
name: Haussler, David
name: Hawkins, Steve
name: Hayami, Shinya
name: Hayashi, Shuto
name: Hayes, D Neil
name: Hayes, Stephen J
name: Hayward, Nicholas K
name: Hazell, Steven
name: He, Yao
name: Heath, Allison P
name: Heath, Simon C
name: Hedley, David
name: Hegde, Apurva M
name: Heiman, David I
name: Heinold, Michael C
name: Heins, Zachary
name: Heisler, Lawrence E
name: Hellstrom-Lindberg, Eva
name: Heo, Seong Gu
name: Hepperla, Austin J
name: Heredia-Genestar, José María
name: Hersey, Peter
name: Hilmarsdottir, Holmfridur
name: Hinton, Jonathan
name: Hirano, Satoshi
name: Hiraoka, Nobuyoshi
name: Hoadley, Katherine A
name: Hoell, Jessica I
name: Hoffmann, Steve
name: Hofmann, Oliver
name: Holbrook, Andrea
name: Holik, Aliaksei Z
name: Hollingsworth, Michael A
name: Holmes, Oliver
name: Holt, Robert A
name: Hong, Eun Pyo
name: Hong, Jongwhi H
name: Hooijer, Gerrit K
name: Hosoda, Fumie
name: Hou, Yong
name: Hovestadt, Volker
name: Howat, William
name: Hoyle, Alan P
name: Hruban, Ralph H
name: Hu, Jianhong
name: Hu, Taobo
name: Hua, Xing
name: Huang, Kuan-lin
name: Huang, Mei
name: Huang, Mi Ni
name: Huang, Vincent
name: Huang, Yi
name: Huber, Wolfgang
name: Hudson, Thomas J
name: Hummel, Michael
name: Hung, Jillian A
name: Huntsman, David
name: Hupp, Ted R
name: Huse, Jason
name: Huska, Matthew R
name: Hutter, Barbara
name: Hutter, Carolyn M
name: Hübschmann, Daniel
name: Iacobuzio-Donahue, Christine A
name: Imbusch, Charles David
name: Imielinski, Marcin
name: Imoto, Seiya
name: Isaacs, William B
name: Ishikawa, Shumpei
name: Iskar, Murat
name: Islam, SM Ashiqul
name: Ittmann, Michael
name: Ivkovic, Sinisa
name: Jacquemier, Jocelyne
name: Jakrot, Valerie
name: Jamieson, Nigel B
name: Jang, Gun Ho
name: Jang, Se Jin
name: Jayaseelan, Joy C
name: Jayasinghe, Reyka
name: Jefferys, Stuart R
name: Jegalian, Karine
name: Jennings, Jennifer L
name: Jeon, Seung-Hyup
name: Jerman, Lara
name: Ji, Yuan
name: Jiao, Wei
name: Johansson, Peter A
name: Johns, Amber L
name: Johns, Jeremy
name: Jolly, Clemency
name: Joly, Yann
name: Jonasson, Jon G
name: Jones, Corbin D
name: Jones, David R
name: Jones, David TW
name: Jones, Nic
name: Jones, Steven JM
name: Jonkers, Jos
name: Ju, Young Seok
name: Juhl, Hartmut
name: Jung, Jongsun
name: Juul, Sissel
name: Jäger, Natalie
name: Kabbe, Rolf
name: Kaiser, Vera B
name: Kakavand, Hojabr
name: Kalimuthu, Sangeetha
name: von Kalle, Christof
name: Kang, Koo Jeong
name: Karaszi, Katalin
name: Karlan, Beth
name: Karlić, Rosa
name: Karsch, Dennis
name: Kasaian, Katayoon
name: Kassahn, Karin S
name: Katai, Hitoshi
name: Kato, Mamoru
name: Katoh, Hiroto
name: Kawakami, Yoshiiku
name: Kay, Jonathan D
name: Kazakoff, Stephen H
name: Kazanov, Marat D
name: Keays, Maria
name: Kebebew, Electron
name: Kefford, Richard F
name: Kench, James G
name: Kennedy, Catherine J
name: Kerssemakers, Jules NA
name: Khoo, David
name: Khoo, Vincent
name: Khuntikeo, Narong
name: Kilpinen, Helena
name: Kim, Hark Kyun
name: Kim, Hyung-Lae
name: Kim, Hyung-Yong
name: Kim, Hyunghwan
name: Kim, Jihoon
name: King, Tari A
name: Klapper, Wolfram
name: Kleinheinz, Kortine
name: Klimczak, Leszek J
name: Knappskog, Stian
name: Kneba, Michael
name: Knoppers, Bartha M
name: Koh, Youngil
name: Komura, Daisuke
name: Komura, Mitsuhiro
name: Kong, Gu
name: Kool, Marcel
name: Korchina, Viktoriya
name: Korshunov, Andrey
name: Koscher, Michael
name: Koster, Roelof
name: Kote-Jarai, Zsofia
name: Koures, Antonios
name: Kovacevic, Milena
name: Kremeyer, Barbara
name: Kretzmer, Helene
name: Kreuz, Markus
name: Krishnamurthy, Savitri
name: Kube, Dieter
name: Kumar, Kiran
name: Kumar, Pardeep
name: Kumar, Yogesh
name: Kundra, Ritika
name: Kübler, Kirsten
name: Küppers, Ralf
name: Lagergren, Jesper
name: Lai, Phillip H
name: Laird, Peter W
name: Lakhani, Sunil R
name: Lalansingh, Christopher M
name: Lalonde, Emilie
name: Lamaze, Fabien C
name: Lambert, Adam
name: Lander, Eric
name: Landgraf, Pablo
name: Landoni, Luca
name: Langerød, Anita
name: Larsimont, Denis
name: Lathrop, Mark
name: Lau, Loretta MS
name: Lawerenz, Chris
name: Lawlor, Rita T
name: Lazar, Alexander J
name: Lazic, Ana Mijalkovic
name: Le, Xuan
name: Lee, Darlene
name: Lee, Eunjung Alice
name: Lee, Hee Jin
name: Lee, Jake June-Koo
name: Lee, Jeong-Yeon
name: Lee, Juhee
name: Lee, Ming Ta Michael
name: Lee-Six, Henry
name: Lehrach, Hans
name: Lenze, Dido
name: Leonard, Conrad R
name: Leongamornlert, Daniel A
name: Leshchiner, Ignaty
name: Letourneau, Louis
name: Letunic, Ivica
name: Levine, Douglas A
name: Lewis, Lora
name: Ley, Tim
name: Li, Chang
name: Li, Constance H
name: Li, Haiyan Irene
name: Li, Jun
name: Li, Lin
name: Li, Siliang
name: Li, Xiaobo
name: Li, Xinyue
name: Li, Yilong
name: Liang, Han
name: Liang, Sheng-Ben
name: Lichter, Peter
name: Lin, Pei
name: Linehan, WM
name: Lingjærde, Ole Christian
name: Liu, Dongbing
name: Liu, Fei-Fei Fei
name: Liu, Fenglin
name: Liu, Jia
name: Liu, Xingmin
name: Livingstone, Julie
name: Livitz, Dimitri
name: Livni, Naomi
name: Loeffler, Markus
name: Long, Georgina V
name: Lopez-Guillermo, Armando
name: Louis, David N
name: Lovat, Laurence B
name: Lu, Yiling
name: Lu, Yong-Jie
name: Lu, Youyong
name: Luchini, Claudio
name: Lungu, Ilinca
name: Luo, Xuemei
name: Luxton, Hayley J
name: Lynch, Andy G
name: Lype, Lisa
name: López, Cristina
name: López-Otín, Carlos
name: Z, Eric
name: Ma, Yussanne
name: MacGrogan, Gaetan
name: MacRae, Shona
name: Macintyre, Geoff
name: Maejima, Kazuhiro
name: Mafficini, Andrea
name: Maglinte, Dennis T
name: Maitra, Arindam
name: Majumder, Partha P
name: Malcovati, Luca
name: Malikic, Salem
name: Malleo, Giuseppe
name: Mann, Graham J
name: Mantovani-Löffler, Luisa
name: Marchegiani, Giovanni
name: Mardis, Elaine R
name: Margolin, Adam A
name: Marin, Maximillian G
name: Markowetz, Florian
name: Markowski, Julia
name: Marks, Jeffrey
name: Marques-Bonet, Tomas
name: Marra, Marco A
name: Marsden, Luke
name: Martens, John WM
name: Martin, Sancha
name: Martin-Subero, Jose I
name: Mashl, R Jay
name: Massie, Charlie E
name: Matthew, Thomas J
name: Matthews, Lucy
name: Mayer, Erik
name: Mayes, Simon
name: Mayo, Michael
name: Mbabaali, Faridah
name: McCune, Karen
name: McDermott, Ultan
name: McLellan, Michael D
name: McPherson, John D
name: McPherson, John R
name: McPherson, Treasa A
name: Meier, Samuel R
name: Meng, Alice
name: Meng, Shaowu
name: Menzies, Andrew
name: Merrett, Neil D
name: Merson, Sue
name: Meyerson, Matthew
name: Mieczkowski, Piotr A
name: Mihaiescu, George L
name: Mijalkovic, Sanja
name: Mikkelsen, Tom
name: Milella, Michele
name: Mileshkin, Linda
name: Miller, Christopher A
name: Miller, David K
name: Miller, Jessica K
name: Mills, Gordon B
name: Milovanovic, Ana
name: Minner, Sarah
name: Miotto, Marco
name: Arnau, Gisela Mir
name: Mirabello, Lisa
name: Mitchell, Chris
name: Mitchell, Thomas J
name: Miyano, Satoru
name: Miyoshi, Naoki
name: Mizuno, Shinichi
name: Molnár-Gábor, Fruzsina
name: Moore, Malcolm J
name: Moore, Richard A
name: Morganella, Sandro
name: Morris, Quaid D
name: Morrison, Carl
name: Mose, Lisle E
name: Moser, Catherine D
name: Mungall, Andrew J
name: Mungall, Karen
name: Musgrove, Elizabeth A
name: Mustonen, Ville
name: Mutch, David
name: Muyas, Francesc
name: Muzny, Donna M
name: Muñoz, Alfonso
name: Myers, Jerome
name: Myklebost, Ola
name: Möller, Peter
name: Nagae, Genta
name: Nagrial, Adnan M
name: Nahal-Bose, Hardeep K
name: Nakagama, Hitoshi
name: Nakamura, Hiromi
name: Nakamura, Toru
name: Nakano, Kaoru
name: Nandi, Tannistha
name: Nangalia, Jyoti
name: Nastic, Mia
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name: Zhang, Fan
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name: Zhang, Hongwei
name: Zhang, Hongxin
name: Zhang, Jiashan
name: Zhang, Junjun
name: Zhang, Xiuqing
name: Zhang, Zemin
name: Zheng, Liangtao
name: Zheng, Xiuqing
name: Zhou, Wanding
name: Zhou, Yong
name: Zhu, Bin
name: Zhu, Hongtu
name: Zhu, Jingchun
name: Zhu, Shida
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Publisher: name: The Francis Crick Institute
Year: 2023
Subjects: classificationCode: Tumour Biology
subject: Tumour Biology
classificationCode: Genetics & Genomics
subject: Genetics &amp; Genomics
classificationCode: Human Biology & Physiology
subject: Human Biology &amp; Physiology
classificationCode: Structural Biology & Biophysics
subject: Structural Biology &amp; Biophysics
classificationCode: Ecology,Evolution & Ethology
subject: Ecology,Evolution &amp; Ethology
classificationCode: Computational & Systems Biology
subject: Computational &amp; Systems Biology

description: The catalog of cancer driver mutations in protein-coding genes has greatly expanded in the past decade. However, non-coding cancer driver mutations are less well-characterized and only a handful of recurrent non-coding mutations, most notably TERT promoter mutations, have been reported. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancer across 38 tumor types, we perform multi-faceted pathway and network analyses of non-coding mutations across 2583 whole cancer genomes from 27 tumor types compiled by the ICGC/TCGA PCAWG project that was motivated by the success of pathway and network analyses in prioritizing rare mutations in protein-coding genes. While few non-coding genomic elements are recurrently mutated in this cohort, we identify 93 genes harboring non-coding mutations that cluster into several modules of interacting proteins. Among these are promoter mutations associated with reduced mRNA expression in TP53, TLE4, and TCF4. We find that biological processes had variable proportions of coding and non-coding mutations, with chromatin remodeling and proliferation pathways altered primarily by coding mutations, while developmental pathways, including Wnt and Notch, altered by both coding and non-coding mutations. RNA splicing is primarily altered by non-coding mutations in this cohort, and samples containing non-coding mutations in well-known RNA splicing factors exhibit similar gene expression signatures as samples with coding mutations in these genes. These analyses contribute a new repertoire of possible cancer genes and mechanisms that are altered by non-coding mutations and offer insights into additional cancer vulnerabilities that can be investigated for potential therapeutic treatments.