cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 5 of Ischemic heart disease-related mortality in Brazil, 2006 to 2020. A study of multiple causes of death
Creators: name: Bastos, Luiz A. V. M.
name: Villela, Paolo B.
name: Bichara, Jose L. P.
name: do Nascimento, Emilia M.
name: Bastos, Eduardo L. V. M.
name: de B Pereira, Basilio
name: Oliveira, Glaucia M. M.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Supplementary Material 5.
Music Therapists’ Self-Compassion, Compassion for Others, and Professional Quality of Life
Creators: name: Rushing, Jamie E.
Publisher: name: University of Kentucky
Year: 2017
Subjects: subject: Music Therapy

description: As helping professionals, music therapists show compassion to their clients but may lack necessary self-care skills to prevent burnout and promote well-being. Due to a lack of research in this area, this study investigated reported levels of compassion for others, self-compassion, burnout, secondary traumatic stress, and compassion satisfaction among music therapists in relation to age, gender, and years of professional experience. A survey of 575 board certified music therapists in the USA revealed higher levels of compassion for others than self-compassion, low levels of burnout and secondary traumatic stress, and high levels of compassion satisfaction. Burnout strongly negatively correlated with both self-compassion and compassion satisfaction and strongly positively correlated with secondary traumatic stress. A MANCOVA revealed significant differences in compassion for others and compassion satisfaction based on gender, with female participants reporting significantly higher scores for both constructs. Additionally, there was a trend related to self-compassion and compassion levels increasing over time. There were strong associations between compassion and self-compassion with burnout and secondary traumatic stress; therefore, it would benefit music therapists to cultivate compassion practices to lower burnout risk.
Oseltamivir-resistant influenza A(H1N1) viruses detected in Europe during season 2007-8 had epidemiologic and clinical characteristics similar to co-circulating susceptible A(H1N1) viruses
Creators: name: Ciancio, B. C.
name: Meerhoff, T. J.
name: Kramarz, P.
name: Bonmarin, I.
name: Borgen, K.
name: Boucher, C. A.
name: Buchholz, Udo
name: Buda, Silke
name: Dijkstra, F.
name: Dudman, S.
name: Duwe, Susanne
name: Hauge, S. H.
name: Hungnes, Olav
name: Meijer, Adam
name: Mossong, J.
name: Paget, W. J.
name: Phin, N.
name: Sande, M. Van Der
name: Schweiger, Brunhilde
name: Nicoll, A.
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2009
Subjects: subject: Adolescent
subject: Preschool
subject: Newborn
subject: Human/epidemiology
subject: Humans
subject: Female
subject: Disease Outbreaks
subject: Male
subject: Middle Aged
subject: Risk Factors
subject: Child
subject: Adult
subject: Case-Control Studies
subject: Cohort Studies
subject: Questionnaires
subject: Aged
subject: Europe/epidemiology
subject: Infant
subject: Retrospective Studies
subject: Odds Ratio
subject: Drug Resistance
subject: Influenza A Virus
subject: H1N1 Subtype/classification
subject: H1N1 Subtype/drug effects
subject: H1N1 Subtype/genetics
subject: Influenza
subject: Human/virology
subject: Seasons
subject: Treatment Outcome
subject: Risk
subject: Young Adult
subject: Antiviral Agents/pharmacology
subject: Viral*/genetics
subject: Oseltamivir/pharmacology*
subject: Practice Guidelines as Topic
subject: 610 Medizin

description: During the 2007-08 influenza season, high levels of oseltamivir resistance were detected among influenza A(H1N1) viruses in a number of European countries. We used surveillance data to describe influenza A(H1N1) cases for whom antiviral resistance testing was performed. We pooled data from national studies to identify possible risk factors for infection with a resistant virus and to ascertain whether such infections led to influenza illness of different severity. Information on demographic and clinical variables was obtained from patients or their physicians. Odds ratios for infection with an oseltamivir resistant virus and relative risks for developing certain clinical outcomes were computed and adjusted through multivariable analysis. Overall, 727 (24.3%) of 2,992 tested influenza A(H1N1) viruses from 22 of 30 European countries were oseltamivir-resistant. Levels of resistance ranged from 1% in Italy to 67% in Norway. Five countries provided detailed case-based data on 373 oseltamivir resistant and 796 susceptible cases. By multivariable analysis, none of the analysed factors was significantly associated with an increased risk of infection with an oseltamivir-resistant virus. Similarly, infection with an oseltamivir-resistant virus was not significantly associated with a different risk of pneumonia, hospitalisation or any clinical complication. The large-scale emergence of oseltamivir-resistant viruses in Europe calls for a review of guidelines for influenza treatment.
The novel CD16A/anti-CD3 bifunctional protein, eCD16A/anti-CD3-BFP, redirects T cell cytotoxicity toward antibody-bound target cells
Creators: name: Lin, Chien-Ting
name: Wu, Shang-Ju
name: Liao, Cheng Hao
name: Weng, Reyhung Roc
name: Lin, Chun-Ming
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Cardiology

description: Monoclonal antibodies enhance innate immunity, while bispecific T cell engager antibodies redirect adaptive T cell immunity. To stimulate both innate and adaptive mechanisms, we created a bifunctional eCD16A/anti-CD3-BFP adapter protein for combined use with clinically approved monoclonal IgG1 antibodies. The adaptor protein contains the extracellular domain of the human CD16A high-affinity variant, which binds the Fc domain of IgG1 antibodies, and an anti-human CD3 single-chain variable fragment that redirects T cell cytotoxicity. Functional characterization of eCD16A/anti-CD3-BFP was performed using in vitro, ex vivo, and in vivo animal assays. Combination treatments of eCD16A/anti-CD3-BFP with rituximab (anti-CD20), cetuximab (anti-EGFR), trastuzumab (anti-HER2) or anti-PD-L1 IgG1 led to specific killing of antigen-expressing tumor cells. In an ex vivo assay, eCD16A/anti-CD3-BFP combined with rituximab effectively eliminated B cells within peripheral blood samples from healthy donors and cancer patients; the effectiveness of this treatment was further enhanced by addition of either autologous or allogeneic γ9δ2 T cells. In mouse xenograft studies, the combination of eCD16A/anti-CD3-BFP and rituximab led to rapid depletion of tumor cells. The presence of non-targeting competing serum immunoglobulins interfered with efficacy, but this interference could be overcome by eCD16A/anti-CD3-BFP dose escalation or by using a Fc-glycoengineered version of rituximab. Moreover, combining eCD16A/anti-CD3-BFP with anti-Epstein Barr virus (EBV) antibodies directed T cell cytotoxicity toward EBV-infected cells. These findings support further development of eCD16A/anti-CD3-BFP as a novel anti-cancer therapeutic to stimulate both innate and adaptive immunity.
Additional file 1 of The role of a community conversation intervention in reducing stigma related to lower limb lymphoedema in Northern Ethiopia
Creators: name: Tora, Abebayehu
name: Bremner, Stephen
name: Ali, Oumer
name: Kinfe, Mersha
name: Mengiste, Asrat
name: Anagnostopoulou, Vasso
name: Fekadu, Abebaw
name: Davey, Gail
name: Semrau, Maya
Publisher: name: figshare
Year: 2024
Subjects: Biological Sciences not elsewhere classified
Cancer
Science Policy

description: Additional file 1. Community survey questionnaire.
Epidemiologisches Bulletin 13 / 2010
Creators: name: Koch-Institut, Robert
Publisher: name: Robert Koch-Institut
Year: 2010
Subjects: subject: Pandemische Influenza (H1N1)
subject: Weltgesundheitstag 2010
subject: 610 Medizin

description: Zum Weltgesundheitstag 2010: Gesundheitsförderung in Städten Der Artikel im Epidemiologischen Bulletin 13/2010 berichtet über die Kampagne der Weltgesundheitsorganisation zur Gesundheitsförderung in Städten. Mit dieser Kampagne soll gezeigt werden, wie das Lebensumfeld sowie die Lebensbedingungen der Bevölkerung in Städten, wo viele Menschen auf engem Raum zusammenleben, gesundheitsförderlicher gestaltet werden kann. Pandemische Influenza (H1N1) 2009 – Ergebnisse zweier Befragungen Im Epidemiologischen Bulletin 13/2010 werden zwei Berichte einer Befragung von Personen, die eine Impfung gegen die pandemische Influenza (H1N1) 2009 erhalten haben, veröffentlicht. Die beiden Erhebungen geben Hinweise zur Bewertung und Überprüfung der durchgeführten Impfkampagne gegen die pandemische Influenza (H1N1) 2009, der Impfbereitschaft und Risikowahrnehmung in der Bevölkerung.
Additional file 2 of The role of a community conversation intervention in reducing stigma related to lower limb lymphoedema in Northern Ethiopia
Creators: name: Tora, Abebayehu
name: Bremner, Stephen
name: Ali, Oumer
name: Kinfe, Mersha
name: Mengiste, Asrat
name: Anagnostopoulou, Vasso
name: Fekadu, Abebaw
name: Davey, Gail
name: Semrau, Maya
Publisher: name: figshare
Year: 2024
Subjects: Biological Sciences not elsewhere classified
Cancer
Science Policy

description: Additional file 2. Patient cohort survey questionnaire.
title: Τμηματοποίηση πελατών και πρόβλεψη πωλήσεων για μια ηλεκτρονική πλατφόρμα πωλήσεων
title: Customer segmentation and sales forecast for e-shop
titleType: AlternativeTitle
Creators: name: Παπανίκου, Αλεξάνδρα
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2024
Subjects: subject: Big data
subject: RFM analysis
subject: Forecasting
subject: Holt Winters

description: Η παρούσα διπλωματική εργασία έχει ως στόχο της αξιοποίηση τεχνολογιών μεγάλων δεδομένων (Big Data), έτσι ώστε να επιτευχθεί η ανάλυση δεδομένων, η τμηματοποίηση πελατών και η πρόβλεψη πωλήσεων μιας ηλεκτρονικής πλατφόρμας πωλήσεων. Η τμηματοποίηση των πελατών διενεργείται με τη χρήση της μεθόδου RFM (Recency, Frequency, Monetary), όπου οι πελάτες ομαδοποιούνται ανάλογα με την πρόσφατη δραστηριότητά τους στην πλατφόρμα, τη συχνότητα των αγορών τους και την οικονομική τους αξία, το οποίο δίνει σημαντικές πληροφορίες τη συμπεριφορά τους. Για την πρόβλεψη των πωλήσεων γίνεται χρήση του μοντέλου Holt-Winters στο οποίο λαμβάνονται υπόψιν οι εποχικές τάσεις και οι διακυμάνσεις των δεδομένων. Το συγκεκριμένο μοντέλο μέσω της εκθετικής εξομάλυνσης, προσφέρει αξιόπιστες προβλέψεις που βοηθούν τις επιχειρήσεις να δημιουργήσουν πιο αποδοτικές στρατηγικές και να διαχειριστούν τα αποθέματα και τους πόρους τους πιο αποτελεσματικά. Τα αποτελέσματα της πρόβλεψης αξιολογούνται και συγκρίνονται με τις πραγματικές πωλήσεις για την επαλήθευση της ακρίβειας του μοντέλου. Τα συνολικά αποτελέσματα της ανάλυσης δείχνουν ότι η χρήση της ανάλυσης RFM και του μοντέλου πρόβλεψης Holt-Winters είναι εφικτό να βελτιώσει σημαντικά τη λήψη αποφάσεων στις επιχειρήσεις, καθώς παρέχεται μια πιο ολοκληρωμένη εικόνα για τη συμπεριφορά των πελατών και τις μελλοντικές τάσεις των πωλήσεων.
Detection of Infectious Poxvirus Particles.
Creators: name: Nitsche, Andreas
name: Stern, Daniel
name: Ellerbrok, Heinz
name: Pauli, Georg
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2006
Subjects: subject: DNA
subject: Cell Line
subject: Viral
subject: Tumor
subject: Humans
subject: Gene Expression Regulation
subject: RNA
subject: Virus Replication
subject: Sensitivity and Specificity
subject: Time Factors
subject: Viral/isolation & purification
subject: Polymerase Chain Reaction/methods
subject: Messenger/isolation & purification
subject: Vaccinia virus/isolation & purification
subject: 610 Medizin

description: To enable rapid and reliable detection of poxviruses in clinical and environmental specimens, a diagnostic approach was developed to detect
Evaluating YOLOv8 and YOLO11 for Real-time Object detection
Creators: name: Anthony Amankwah
name: Chris Aldrich
Publisher: name: Zenodo
Year: 2025

description: Object detection is one of the important and challenging task in industrial machine vision. In this work, we evaluate YOLO8 and YOLO11 which are among the latest version of YOLO (you only look one) which one-stage deep learning detector. We use small datasets of 140 images per class and 20 image per class for racoons and mushrooms respectively. We present the accuracy and precision results of YOLO8 and YOLO11. The results show that the performance of YOLO11 is similar to YOLO8 after 100 epochs. The mean average precision (mAP) using the datasets for YOLOv8 and YOLO11 are 0.919 and 0.916 respectively
title: Επιδράσεις της ακτινοβολίας νετρονίων σε πολυπύρηνο undervolted AMD x86 επεξεργαστή - Μεθοδολογία και ανάλυση αποτελεσμάτων
title: Effects of neutron radiation in a multicore undervolted AMD x86 processor - Methodology and analysis of the results
titleType: AlternativeTitle
Creators: name: Αργυρίου, Κωνσταντίνος
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2024
Subjects: subject: Επεξεργαστής
subject: Ακτινοβολία
subject: AMD
subject: Undervolt
subject: Πείραμα
subject: Σφάλματα
subject: Καταχωρητής
subject: Αρχιτεκτονική

description: Η ραγδαία αύξηση των επιδόσεων στους επεξεργαστές λόγω των μικροσκοπικών μεγεθών των τρανζίστορ, μεγέθη που φτάνουν μόλις μερικά νανόμετρα, και των τεχνολογιών που βελ- τιώνουν την απόδοση του επεξεργαστή σε υλικό επίπεδο, όπως η διοχέτευση και η ιεραρχία μνήμης, έχουν προκαλέσει μια επανάσταση στον χώρο, με ταχύτερους επεξεργαστές από ποτέ. ΄Ομως, λόγω της πολύπλοκης αρχιτεκτονικής και όλο και αυξανόμενης ζήτησης για επιπλέον ταχύτητες, οι επεξεργαστές έφτασαν σε ένα σημείο που αρχίζουν και καταναλώνουν πολύ παραπάνω ενέργεια. Επιπλέον, λόγω των μικροσκοπικών αυτών μεγεθών που έχουν ϕτάσει τα τρανζίστορ, έχει έρθει στην επιφάνεια άλλο ένα σημαντικό πρόβλημα. Υψηλής ενέργειας σωματίδια προερχόμενα από κοσμικές πηγές ακτινοβολίας είναι σε θέση να αλλάζουν την κατάσταση ενός τρανζίστορ [1], αν δοθεί το απαραίτητο φορτίο, ανοίγοντας έτσι συζητήσεις περί ακεραιότητας των δεδομένων που βρίσκονται στις Caches και στην σωστή λειτουργία του επεξεργαστή.
The Roles of Activin A and B in Liver Inflammation and Fibrosis
Creators: name: Hamang, Matthew Joseph
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Plant cell and molecular biology
Animal cell and molecular biology

description: Liver fibrosis is the result of different types of chronic liver diseases, such as cholestatic liver disease and nonalcoholic steatohepatitis, among others. Fibrosis, if left unchecked, may progress to the point of cirrhosis – permanently affecting liver function detrimentally and potentially leading to development of hepatocellular carcinoma. Inflammatory response following tissue injury is vital for the initiation of fibrosis; chronic inflammation results in abnormal tissue healing and promotes a pro-fibrogenic response. Activins are cytokines that have been identified as members of the TGFβ superfamily of growth and differentiation factors. Activin A and B, in particular, have been identified as having roles in the pathophysiology of liver disease, but have not been investigated thoroughly. We treated mice with concanavalin A, a potent T-cell mitogen with liver specificity when administered intravenously, and characterized the resulting response to liver injury and how activin A and B are modulated during this acute inflammatory phase. We showed that activin B is highly increased in circulation following inflammation, as well as locally in the liver as well as the spleen. We then neutralized activin A and B via neutralizing antibodies in our concanavalin A-induced liver injury model to determine if inhibition of these ligands may confer protective effects during the acute inflammatory response in liver. Neutralization of either activin A or activin B protected hepatocytes, improved liver function, and significantly reduced circulating cytokines following concanavalin A administration. Finally, we determined whether inhibition of activin A or B might prevent or reverse the development of liver fibrosis after disease has been established. We induced liver fibrosis in mice via the hepatotoxin carbon tetrachloride, and then treated with neutralizing antibodies while still maintaining carbon tetrachloride administration. Neutralization of activin A and B markedly reduced liver fibrosis, protected hepatocytes, and improved liver function. Our findings implicate both activin A and B as major players in the acute inflammatory response to liver injury, as well as during chronic injury and fibrogenesis, and demonstrate the therapeutic potential of targeting these ligands for the treatment of fibrosis in chronic liver diseases.
Two siblings with immunodeficiency, facial abnormalities and chromosomal instability without mutation in DNMT3B gene but liability towards malignancy; a new chromatin disorder delineation?
Creators: name: Polityko, Anna
name: Khurs, Olga
name: Rumyantseva, Natalia
name: Naumchik, Irina
name: Kosyakova, Nadezda
name: Tönnies, Holger
name: Sperling, Karl
name: Neitzel, Heidemarie
name: Weise, Anja
name: Liehr, Thomas
Publisher: name: Robert Koch-Institut
Year: 2010
Subjects: subject: 610 Medizin

description: Background: ICF syndrome (standing for Immunodeficiency, Centromere instability and Facial anomalies syndrome) is a very rare autosomal recessive immune disorder caused by mutations of the gene de novo DNAmethyltransferase 3B (DNMT3B). However, in the literature similar clinical cases without such mutations are reported, as well. Results: We report on a family in which the unrelated spouses had two female siblings sharing similar phenotypic features resembling ICF-syndrome, i.e. congenital abnormalities, immunodeficiency, developmental delay and high level of chromosomal instability, including high frequency of centromeric/pericentromeric rearrangements and breaks, chromosomal fragments despiralization or pulverization. However, mutations in DNMT3B could not be detected. Conclusion: The discovery of a new so-called ‘chromatin disorder’ is suggested. Clinical, molecular genetic and cytogenetic characteristics are reported and compared to other ‘chromatin disorders’.
Retrowrite: Statically Instrumenting COTS Binaries for Fuzzing and Sanitization
Creators: name: Dinesh, Sushant
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: System and network security
Programming languages

description: End users of closed-source software currently cannot easily analyze the securityof programs or patch them if ﬂaws are found. Notably, end users can include developers who use third party libraries. The current state of the art for coverage-guidedbinary fuzzing or binary sanitization is dynamic binary translation, which resultsin prohibitive overhead. Existing static rewriting techniques cannot fully recoversymbolization information, and so have diﬃculty modifying binaries to track codecoverage for fuzzing or add security checks for sanitizers.The ideal solution for adding instrumentation is a static rewriter that can intelligently add in the required instrumentation as if it were inserted at compile time.This requires analysis to statically disambiguate between references and scalars, aproblem known to be undecidable in the general case. We show that recovering thisinformation is possible in practice for the most common class of software and libraries: 64 bit, position independent code. Based on our observation, we design abinary-rewriting instrumentation to support American Fuzzy Lop (AFL) and AddressSanitizer (ASan), and show that we achieve compiler levels of performance, while retaining precision. Binaries rewritten for coverage-guided fuzzing using RetroWriteare identical in performance to compiler-instrumented binaries and outperforms thedefault QEMU-based instrumentation by 7.5x while triggering more bugs. Our implementation of binary-only Address Sanitizer is 3x faster than Valgrind memcheck,the state-of-the-art binary-only memory checker, and detects 80% more bugs in oursecurity evaluation.
Opportunities and challenges of immuno-oncology: A bibliometric analysis from 2014 to 2023
Creators: name: Zhang, Siqi
name: Miao, Lina
name: Tian, Xiaoxia
name: Yang, Bingxu
name: Luo, Baoping
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Cancer
Science Policy

description: The emergence of immuno-oncology (IO) has led to revolutionary changes in the field of cancer treatment. Despite notable advancements in this field, a thorough exploration of its full depth and extent has yet to be performed. This study provides a comprehensive overview of publications pertaining to IO. Publications on IO from 2014 to 2023 were retrieved by searching the Web of Science Core Collection database (WoSCC). VOSviewer software and Citespace software were used for the visualized analysis. A total of 1,874 articles have been published in the IO domain. The number of publications and citations has been increasing annually. This study also examines the primary research directions within the field of IO. In conclusion, this study offers a comprehensive overview of the opportunities and challenges associated with IO, illuminating the current status of research and indicating potential future trajectories in this rapidly progressing field. This study provides a comprehensive survey of the current research status and hot spots within the field of IO. It will assist researchers in comprehending the current research emphasis and development trends in this field and offers guidance for future research directions.
Developing and Managing a Successful Scholarly Project: Translations
Creators: name: Fulton, Bruce
name: Hanscom, Christopher P.
name: Jeong, Kelly Y.
name: Poole, Janet
Publisher: name: Humanities Commons
Year: 2023

description: "Developing and Managing a Successful Scholarly Project: Translations," by Janet Poole, Kelly Y. Jeong, Christopher P. Hanscom, and Bruce Fulton, an essay from the Modern Language Association's 2022 collection Publishing and Scholarly Communication in the Humanities
The Militia House
Creators: name: Milas, John S
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Creative arts, media and communication curriculum and pedagogy

description: John, it is October, 2001. The U.S. has just occupied Afghanistan, and you’re happy about that, but you’re only twelve years old, too young to act on any nationalistic impulses. In your eighth grade yearbook at age fourteen, you’ll write in your third person biography that someday you hope to be an author and a U.S. Marine. When you’re nineteen, you’ll enlist in the Marines, and then join the occupation of Afghanistan at age twenty-one, from which you’ll return home safely. Now you’re twenty-three and you’re going back to school, mature enough to understand the complicit nature of your involvement in Operation Enduring Freedom. By the time you reach grad school at age twenty-seven, you’ll begin to feel a nagging guilt, and you’ll bear the full impact of this guilt by the time you turn thirty and begin writing your thesis. You’ll want to write a book reflecting your experience in a real-life war, describing what it was like to be there, and what it was like to be a part of something that people had forgotten about before you were even old enough to participate. Instead of reporting the facts, which you will do on many occasions throughout your book-length project entitled The Militia House, you’ll write about the experience as a haunting. John, if this manuscript reaches your hands in 2001 via some means of time travel, I want you to know that you’ll have accomplished your goals, but at a significant cost. Even though you will survive the war, you’ll leave a part of yourself in Afghanistan forever. But perhaps even worse, a piece of Afghanistan will come back with you to live inside of your body and your mind, and it will haunt you for the rest of your life.
Additional file 4 of A meta-analysis and trial sequential analysis of randomised controlled trials comparing nonoperative and operative management of chest trauma with multiple rib fractures
Creators: name: Hisamune, Ryo
name: Kobayashi, Mako
name: Nakasato, Karin
name: Yamazaki, Taiga
name: Ushio, Noritaka
name: Mochizuki, Katsunori
name: Takasu, Akira
name: Yamakawa, Kazuma
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Cell Biology
Science Policy
Mental Health

description: Additional file 4. Search strategy in MEDLINE using a combination of keywords and Medical Subject Headings (MeSH) terms.
Challenging Capitalist-Oppressive Systems in Academia: New Projects with Iterative, Critical Design, and Collaborative Models
Creators: name: Fernández Quintanilla, Sylvia
Publisher: name: Humanities Commons
Year: 2023
Subjects: subject: Capitalism
subject: Humanities
subject: FOS: Humanities
subject: Project management

description: "Challenging Capitalist-Oppressive Systems in Academia: New Projects with Iterative, Critical Design, and Collaborative Models," by Sylvia Fernández Quintanilla, an essay from the Modern Language Association's 2022 collection Publishing and Scholarly Communication in the Humanities
Targeting murine metastatic cancers with cholera toxin A1-adjuvanted peptide vaccines
Creators: name: Paul, Sanchari
name: Kaya, Mustafa
name: Johnsson, Olivia
name: Wiktorin, Hanna Grauers
name: Törnell, Andreas
name: Arabpour, Mohammad
name: Hellstrand, Kristoffer
name: Martner, Anna
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: The dissemination of tumor cells with ensuing metastasis is responsible for most cancer-related deaths. Cancer vaccines may, by inducing tumor-specific effector T cells, offer a strategy to eliminate metastasizing tumor cells. However, several obstacles remain in the development of effective cancer vaccines, including the identification of adjuvants that enhance the evolvement and efficacy of tumor-specific T cells. Cholera toxin-based adjuvants have shown efficacy in vaccines for infectious diseases, but their role in cancer vaccine therapies remains to be elucidated. Here, we explored the potential of cholera toxin A1 (CTA1)-based adjuvants to boost anti-tumor T cell responses and protect against metastasis. We report that an adjuvant where CTA1 was fused to a dimer from Staphylococcus aureus protein A (DD) enhanced immune responses against the tumor-associated antigens TRP2 and Twist1 in mice, providing protection against B16F1 melanoma and 4T1 breast cancer metastasis, respectively. Both mucosal (intranasal) and systemic (intraperitoneal) vaccine administration provided effective protection against intravenously injected tumor cells, with intranasal administration leading to superior induction of CD4+ T cells at metastatic sites. When comparing antigens admixed with CTA1-DD to those fused with a CTA1-based adjuvant, the fusion construct elicited the strongest immunogenicity. Nevertheless, by administrating a 20-fold higher antigen dose also the admix formulation provided efficient protection against metastasis.
Pre- and Post-Processing Workflow for Affinity Purification Mass Spectrometry Data
Creators: name: Fischer, Martina
name: Zilkenat, Susann
name: Gerlach, Roman
name: Wagner, Samuel
name: Renard, Bernhard Y.
Publisher: name: Robert Koch-Institut
Year: 2014
Subjects: subject: AP-MS data analysis
subject: label-free
subject: pre-post-processing
subject: protein−protein interactions
subject: spectral counting
subject: 610 Medizin

description: The reliable detection of protein–protein interactions by affinity purification mass spectrometry (AP-MS) is crucial for the understanding of biological processes. Quantitative information can be used to separate truly interacting proteins from false-positives by contrasting counts of proteins binding to specific baits with counts of negative controls. Several approaches have been proposed for computing scores for potential interaction proteins, for example, the commonly used SAINT software. However, it remains a subjective decision where to set the cutoff score for candidate selection; furthermore, no precise control for the expected number of false-positives is provided. In related fields, successful data analysis strongly relies on statistical pre- and post-processing steps, which, so far, have played only a minor role in AP-MS data analysis. We introduce a complete workflow, embedding either the scoring method SAINT or alternatively a two-stage Poisson model into a pre- and post-processing framework. To this end, we investigate different normalization methods and apply a statistical filter adjusted to AP-MS data. Furthermore, we propose permutation and adjustment procedures, which allow the replacement of scores by statistical p values. The performance of the workflow is assessed on simulations as well as on a study focusing on interactions with the T3SS in Salmonella Typhimurium. Preprocessing methods significantly increase the number of detected truly interacting proteins, while a constant false-discovery rate is maintained. The software solution is freely available.
N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A
Creators: name: Yao, Guorui
name: Zhang, Sicai
name: Mahrhold, Stefan
name: Lam, Kwok-Ho
name: Stern, Daniel
name: Bagramyan, Karine
name: Perry, Kay
name: Kalkum, Markus
name: Rummel, Andreas
name: Dong, Min
name: Jin, Rongsheng
Publisher: name: Robert Koch-Institut, Biologische Sicherheit
Year: 2016
Subjects: subject: 610 Medizin

description: Botulinum neurotoxin serotype A1 (BoNT/A1), a licensed drug widely used for medical and cosmetic applications, exerts its action by invading motoneurons. Here we report a 2.0-Å-resolution crystal structure of the BoNT/A1 receptor-binding domain in complex with its neuronal receptor, glycosylated human SV2C. We found that the neuronal tropism of BoNT/A1 requires recognition of both the peptide moiety and an N-linked glycan on SV2. This N-glycan—which is conserved in all SV2 isoforms across vertebrates—is essential for BoNT/A1 binding to neurons and for its potent neurotoxicity. The glycan-binding interface on SV2 is targeted by a human BoNT/A1-neutralizing antibody currently licensed as an antibotulism drug. Our studies reveal a new paradigm of host-pathogen interactions, in which pathogens exploit conserved host post-translational modifications, thereby achieving highly specific receptor binding while also tolerating genetic changes across multiple isoforms of receptors.
Additional file 1 of Plasmon assisted synthesis of TiN-supported single-atom nickel catalysts
Creators: name: De Silva, Keeniya-Gamalage-Gehan Chaturanga
name: Helsel, Naomi
name: Jeyashangararaj, Hirithya Sharad
name: Choudhury, Pabitra
name: Chowdhury, Sanchari
Publisher: name: figshare
Year: 2024
Subjects: Biophysics
Physical Sciences not elsewhere classified
Medicine
Cell Biology
Molecular Biology
Biotechnology
Chemical Sciences not elsewhere classified
Computational Biology

description: Additional file 1. Schematic representations of TiN, TixOyNz, and TiO2 used for DFT simulations (Fig. SI.1-3). Theoretically calculated absorption efficiency for 20 nm TiN nanoparticles with varying oxide layer surface thickness (Fig. SI.4). N 1S XPS peak and XRD plots of TiN (Fig. SI.5-6). In-situ photodeposition using FTIR experimental setup and results (Fig. SI.7). Explanation of experimental kinetic studies. HAADF-STEM image of control TiN sample with Ni salt in the absence of light (Fig. SI.8). TEM EDS analysis plot and maps confirming Ni deposition on TiN (Fig. SI.9-10). Schematic representations of Ni binding sites on TiN, TixOyNz, and TiO2 used for DFT simulations (Fig. SI.11-12). DFT calculated nickel oxidation states for increasing OH groups present on TiN, TixOyNz, and TiO2 surfaces (Fig. SI.13). The DFT-calculated electron differences after deposition for TiN, TixOyNz, and TiO2(Table SI.1).
Fundamental Limits to Collective Sensing in Cell Populations
Creators: name: Fancher, Sean C
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Biological physics

description: Cells live in inherently noisy environments. The machinery that cells use to sense their environment is also noisy. Yet, cells are exquisite environmental sensors, often approaching the limits of what is physically possible. This thesis investigates how the precision of environmental sensing is improved when cells behave collectively. We derive physical limits to cells' ability to collectively sense and respond to chemical concentrations and gradients. For concentration sensing, we find that when cell populations become sufficiently large, long-range communication can provide higher sensory precision than short-range communication, and that the optimal cell-cell separation in such a system can be large, due to a tradeoff between maintaining communication strength and reducing signal cross-correlations. We also show that concentration profiles formed diffusively are more precise for large profile lengths while those formed via directed transport are more precise for short profile lengths. These effects are due to increased molecule refresh rate and mean concentration respectively. For gradient sensing, we derive the sensory precision of the well-known the local excitation-global inhibition (LEGI) model and the more recently proposed regional excitation-global inhibition (REGI) model for two and three dimensional cell cluster geometries. We find that REGI systems achieve higher levels of precision than LEGI systems and give rise to optimally sensing geometries that are consistent with the shapes of naturally occurring gradient-sensing cell populations. Lastly, we analyze the precision with which migrating cell clusters can track a chemical gradient via an individual-based and emergent method. We show that one and two dimensional clusters utilizing the emergent chemotactic method have improved scaling with population size due to differences in the scaling properties of the variance in the total polarization. By completing these studies we aim to understand the limits and precise roles of collective behavior in environmental sensing.
Knowledge mapping and visualized analysis of research progress in onconephrology: a bibliometric analysis
Creators: name: Wang, Yiwei
name: Fan, Shuling
name: Wang, Wei
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Medicine
Marine Biology
Science Policy

description: Onconephrology is an expanding subspecialty focused on the management of cancer patients with renal injury. This study used a comprehensive bibliometric analysis to emphasize the need for cooperation between oncologists and nephrologists, exploring current trends and future research areas in onconephrology. Relevant literature on onconephrology published between 1 January 2000 and 27 April 2024 was retrieved from the Science Citation Index Expanded of the Web of Science Core Collection, followed by manual screening. Bibliometric analyses were performed using CiteSpace, VOSviewer, and Bibliometrix software. A total of 1,853 publications, including 1,647 articles and 206 reviews, by 11,606 authors from 2,757 institutions in 73 countries, were analyzed. Annual publications generally follow a steadily increasing trend, ranging from 25 to 161 documents. The United States (n = 464), The University of Texas MD Anderson Cancer Center (n = 39), Meletios A. Dimopoulos (n = 21), and Nephrology Dialysis Transplantation (n = 35) were the most productive country, institution, author, and journal, respectively. Immune checkpoint inhibitors, glomerular filtration rate, and cisplatin were clusters of highly cited references after 2015. Oxaliplatin, calcium, open-label, and thrombotic microangiopathy were trending topics after 2020. Outcome, acute kidney injury, immunotherapy, and chronic kidney disease were keyword bursts that persisted through 2024. Current research of onconephrology is focusing on chemotherapeutic nephrotoxicity, kidney function assessment, dosing of chemotherapeutic agents in chronic kidney disease, glomerular disease in cancer, immunotherapy, and electrolyte disturbances. Future directions in this field include clinical trials and thrombotic microangiopathy.
Temporal dynamics of online petitions
Creators: name: Böttcher, Lucas
name: Woolley-Meza, Olivia
name: Brockmann, Dirk
Publisher: name: Robert Koch-Institut
Year: 2017
Subjects: subject: 610 Medizin

description: Online petitions are an important avenue for direct political action, yet the dynamics that determine when a petition will be successful are not well understood. Here we analyze the temporal characteristics of online-petition signing behavior in order to identify systematic differences between popular petitions, which receive a high volume of signatures, and unpopular ones. We find that, in line with other temporal characterizations of human activity, the signing process is typically non-Poissonian and non-homogeneous in time. However, this process exhibits anomalously high memory for human activity, possibly indicating that synchronized external influence or contagion play and important role. More interestingly, we find clear differences in the characteristics of the inter-event time distributions depending on the total number of signatures that petitions receive, independently of the total duration of the petitions. Specifically, popular petitions that attract a large volume of signatures exhibit more variance in the distribution of inter-event times than unpopular petitions with only a few signatures, which could be considered an indication that the former are more bursty. However, petitions with large signature volume are less bursty according to measures that consider the time ordering of inter-event times. Our results, therefore, emphasize the importance of accounting for time ordering to characterize human activity.
Thermal Metrology for Waste Heat Systems: Thermoelectrics to Phase Change Materials
Creators: name: Miers, Collier S
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Engineering instrumentation
Computational methods in fluid flow, heat and mass transfer (incl. computational fluid dynamics)
Mechanical engineering not elsewhere classified

description: This dissertation presents the development of two unique measurement platforms.

The first system is a high-temperature Z-Meter. This system is designed to simultaneously measure the electrical resistivity, Seebeck coefficient, and thermal conductivity of a thermoelectric sample to accurately determine the figure of merit, ZT, for that material. It is designed to operated at sample temperatures of up to 1000C, and with temperature gradients on the order of 500C across the sample. This system also provides in situ load monitoring for contact pressure and allows the user to adjust loading during the experiment.

The second part of this dissertation focuses on the development of enhanced composite phase change material (PCM) heat sinks to improve passive thermal management in mobile electronics. We present a new design for a composite PCM heat sink and utilize off-the-shelf PCMs to show characterize the performance. In order to accurately investigate the performance enhancement of these designs, we develop a turn-key thermal management evaluation platform to allow the user complete control over the power profiles and cycling applied to the test chip, as well as providing in situ temperature monitoring within the chip. The proposed package designs show significant improvement in the length of time extended before reaching the cut-off temperature within the heatfluxes tested, 6 - 14 W/cm^2, and accomplish this while weighing less than the equivalent sensible heat storage design.
A Role of Sp1 Binding Motifs in Basal and Large T-Antigen-Induced Promoter Activities of Human Polyomavirus HPyV9 and Its Variant UF-1
Creators: name: Moens, Ugo
name: Song, Xiaobo
name: Ghelue, Marijke Van
name: Lednicky, John A.
name: Ehlers, Bernhard
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2017
Subjects: subject: large T antigen
subject: luciferase
subject: mutation
subject: non-coding control region
subject: Sp1
subject: 610 Medizin

description: Human polyomavirus 9 (HPyV9) was originally detected in the serum of a renal transplant patient. Seroepidemiological studies showed that ~20–50% of the human population have antibodies against this virus. HPyV9 has not yet been associated with any disease and little is known about the route of infection, transmission, host cell tropism, and genomic variability in circulating strains. Recently, the HPyV9 variant UF-1 with an eight base-pair deletion, a thirteen base-pair insertion and with point mutations, creating three putative Sp1 binding sites in the late promoter was isolated from an AIDS patient. Transient transfection studies with a luciferase reporter plasmid driven by HPyV9 or UF1 promoter demonstrated that UF1 early and late promoters were stronger than HPyV9 promoters in most cell lines, and that the UF1 late promoter was more potently activated by HPyV9 large T-antigen (LTAg). Mutation of two Sp1 motifs strongly reduced trans-activation of the late UF1 promoter by HPyV9 LTAg in HeLa cells. In conclusion, the mutations in the UF1 late promoter seem to strengthen its activity and its response to stimulation by HPyV9 LTAg in certain cells. It remains to be investigated whether these promoter changes have an influence on virus replication and affect the possible pathogenic properties of the virus.
Conscience, Human Nature, and the Evolutionary Challenge
Creators: name: Johnson, Brian Michael
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Philosophy not elsewhere classified

description: The purpose of this dissertation is to rebut some skeptical arguments in moral epistemology by appealing to philosophical resources from the history of European philosophy. The skeptical arguments I will be countering are grounded in the perspective of contemporary biology. Put quickly, our evolutionary history is said to undermine our claims to moral knowledge because the process by which our capacity for such knowledge developed was determined by adaptive and reproductive fitness. The determinations of fitness, it is said, cannot be expected to align with standards of objective moral value. In the first chapter, I spell out the importance of evaluative perception. The need for a capacity to perceive value raises the concern that moral psychology is something mysterious. In the second chapter, I consider some skeptical arguments in moral epistemology that conclude we have no good reason to believe we are wired to be receptive to objective moral truth. While some of these arguments purport to undermine our access toobjective moral truths, I conclude that they do not. The remainder of the dissertation considers the work of Rousseau, Kant, and Hegel in light of the concerns raised in part one. Despite initial appearances, these authors understand the relation of conscience and human nature in a way that points toward a defensible view, even in light of the challenges raised by contemporary biology. The resulting view is an account of the moral conscience that emphasizes autonomy and rational agency and recognizes their value in virtue of their concrete expression in a social context.
Epidemiologie des CUP-Syndroms in Deutschland
Creators: name: Kraywinkel, Klaus
name: Zeissig, Sylke Ruth
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2017
Subjects: subject: „Cancer of unknown primary“
subject: Amtliche Todesursachsenstatistik
subject: Krebsregister
subject: Adenokarzinom
subject: Plattenepithelkarzinom
subject: 610 Medizin

description: Der Artikel gibt einen Überblick über Inzidenz‑, Mortalitäts- und Überlebensraten des „cancer of unknown primary“ (CUP) in Deutschland, beruhend auf den Daten der epidemiologischen Krebsregister in Deutschland sowie der amtlichen Todesursachsenstatistik. Danach erkrankten in Deutschland zuletzt jährlich rund 11.000 Personen an einem CUP, was einem Anteil von 2,3 % an allen Malignomen entspricht. Bei knapp 10.000 Menschen wird ein unbekannter oder nicht näher bezeichneter Primärtumor (ICD-10: C80) als Todesursache angegeben. Aktuelle internationale Vergleichsdaten deuten allerdings darauf hin, dass die Inzidenz für das echte CUP-Syndrom eher niedriger liegen dürfte, wahrscheinlich weil die Unterscheidung zwischen einem tatsächlich unbekannten und einem lediglich nicht näher bezeichneten Primärtumor v. a. bei den nur über Todesbescheinigungen identifizierten Fällen schwierig ist. Morphologisch überwiegt das Adenokarzinom; in etwa 30 % der Fälle sind nur unspezifische Histologien angegeben. Die Prognose des CUP entspricht mit relativen Fünfjahresüberlebensraten um 18 % etwa der des Lungenkarzinoms, wobei Patienten in jüngerem Alter und solche mit Plattenepithelkarzinomen deutlich höhere Überlebenschancen aufweisen.
Additional file 1 of Spanish validation of the short version of the racing and crowded thoughts questionnaire (RCTQ-13)
Creators: name: Rodríguez, Daniela Garcés
name: Zapata-Ospina, Juan Pablo
name: Uribe, María Mercedes
name: Suarez, Diana
name: Tabares, Luis Fernando
name: Ahunca, Luisa Fernanda
name: Aguirre, Daniel Camilo
name: Holguín, Jorge Carlos
name: Valencia, Jenny García
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Science Policy
Mental Health

description: Supplementary material 1.
Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection
Creators: name: Sy, Bui Tien
name: Hoan, Nghiem Xuan
name: Tong, Hoang Van
name: Meyer, Christian G.
name: Toan, Nguyen Linh
name: Song, Le Huu
name: Bock, Thomas
name: Velavan, Thirumalaisamy P.
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2018
Subjects: subject: Hepatitis B virus infection
subject: Liver diseases
subject: IRF5
subject: IFR5 polymorphisms
subject: IFR5 haplotypes
subject: 610 Medizin

description: Aim: To investigate possible effects of IRF5 polymorphisms in the 3’ UTR region of the IFR5 locus on susceptibility to hepatitis B virus (HBV) infection and progression of liver diseases among clinically classified Vietnamese patients.Methods: Four IFR5 SNPs (rs13242262A/T, rs77416878C/T, rs10488630A/G, and rs2280714T/C) were genotyped in clinically classified HBV patients [chronic hepatitis B (CHB). n = 99; liver cirrhosis (LC), n = 131; hepatocellular carcinoma (HCC), n = 149] and in 242 healthy controls by direct sequencing and TaqMan real-time PCR assays. Results: Comparing patients and controls, no significant association was observed for the four IFR5 variants. However, the alleles rs13242262T and rs10488630G contributed to an increased risk of liver cirrhosis (LC vs CHB: OR = 1.5, 95%CI: 1.1-2.3, adjusted P = 0.04; LC vs CHB: OR = 1.7, 95%CI: 1.1-2.6, adjusted P = 0.019). Haplotype IRF5*TCGT constructed from 4 SNPs was observed frequently in LC compared to CHB patients (OR = 2.1, 95%CI: 1.2-3.3, adjusted P = 0.008). Haplotype IRF5*TCAT occurred rather among CHB patients than in the other HBV patient groups (LC vs CHB: OR = 0.4, 95%CI: 0.2-0.8, adjusted P = 0.03; HCC vs CHB: OR = 0.3, 95%CI: 0.15-0.7, adjusted P = 0.003). The IRF5*TCAT haplotype was also associated with increased levels of ALT, AST and bilirubin. Conclusion: Our study shows that IFR5 variants may contribute as a host factor in determining the pathogenesis in chronic HBV infections.