cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Planning and postponing the urban reform of Coimbra’s downtown
Creators: name: Calmeiro, Margarida
Publisher: name: International Planning History Society Proceedings
Year: 2016

description: In this communication I intend to analyse the process of transformation and modernization of Coimbra’s downtown neighbourhood, firstly carried out to face the recurrent flooding of the Mondego’s river but moreover as a beautification plan within the European models. After several attends to minimize recurrent floods, only the development of science and technology during the nineteen century made possible the construction of a new river bank and consequently a set of reform projects planning a new regular and wealthy neighbourhood. Coimbra was a middle size city nevertheless, until the beginning of the twenty century, it was the settlement of the only Portuguese University, fact that gave the city a huge importance not only within the country but also in the empire. However like all Portuguese cities in this period, Coimbra faced several sanitary problems due to the absence of a water and sewer network, lighting infrastructures or public transports, in addition in Coimbra these problems were enlarged by the recurrent floods. The solution was the construction of a new bank planned and executed by the state engineers but partial paid by the municipality. The construction of the new river front endorsed the reform of the main city entrance, the construction of a new bridge and a square, the enlargement of the Main Street and the construction of a boulevard by the river. Moreover this plan required the skills of a new technician, the first municipal engineer. Few years after, the riverfront and the image of Coimbra were once more reconfigured to implant the new train station and a new train line to the interior of Portugal, increasing the embankment 38 meters into the river. With this project began a new phase of planning that spans until nowadays. It started with the opening of a boulevard connecting the station and the town hall then in the begging of the twenty century, within the principles in vogue in Europe, the plan was extended proposing a set of wide avenues to sanitize the old unhealthy neighbourhood, emulating Haussmann’s model to Paris. However financial difficulties and lack of government support postponed this ambitious plan nevertheless it was not overlooked, being followed by a succession of plans and becoming a part of the collective imagination. This paper analyses this set of plans, its motivations and its relation with the international models. Nevertheless it also explores its process, emphasizing the role of the population yearning for the reform of the old core and the municipal council’s efforts to execute these plans. Furthermore stress the consequences of these unrealized plans for the transformation and grow of the rest of the city.
description: International Planning History Society Proceedings, Vol. 17 No. 6 (2016): HISTORY URBANISM RESILIENCE: Scales and Systems
Essays in Microeconomics
Creators: name: Rakic, Ruzica
Publisher: name: Humboldt-Universität zu Berlin
Year: 2017
Subjects: subject: Wettbewerb
subject: Fusion
subject: teilweise Übernahme
subject: Investition
subject: Forschung-und Entwicklung (FuE)
subject: Mediation
subject: Competition
subject: merger
subject: partial acquisition
subject: investment
subject: research and development (R&D
subject: mediation
subject: 330 Wirtschaft
subject: QC 100

description: Diese Dissertation besteht aus drei unabhängigen Kapiteln über mikroökonomische Themen. Die ersten beiden Kapitel befassen sich mit Themen der Industriökonomie und Wettbewerbstheorie, wohingegen das dritte Kapitel Fragestellungen von Cheap Talk Spielen untersucht. Kapitel 1 untersucht die Folgen, die sich aus einer partiellen Akquisition zwischen Wettbewerbern ergeben. Kapitel 2 analysiert die Auswirkungen einer Forschungs-und Entwicklungs (FuE)- Kooperation auf die Investitionsanreize in einem Markt, in dem eine Mehrproduktunternehmer mit einem Einzelproduktuntfirma konkurriert. Kapitel 3 untersucht die Funktion der Mediation zur Erleichterung der Kommunikation mit privaten Informationen.
description: This dissertation consists of three independent chapters in the field of microeconomics. The first two chapters are concerned with topics of industrial organization and competition policy, whereas the third chapter addresses some problems in cheap talk games. Chapter 1 studies anti-competitive issues that arise from partial acquisition between competitors. Chapter 2 analyzes the effects of cooperation on R&D investment incentives in a market where a multi-product firm competes with a single-product firm. The third chapter examines the role of mediation in facilitating communication with private information.
Transformation of Exposition Space at an Urban Scale
Creators: name: Tuncbilek, Gonca
Publisher: name: International Planning History Society Proceedings
Year: 2016

description: International expositions began to gain popularity in late 19th century, particularly in Europe, and in time came to influence both architecture and urban planning, affecting their historical development. Expositions serve as a means of displaying architecture, particularly since industrialization, and have an influence that can transform their surrounding metropolitan areas in different ways. These influenced areas extend way beyond their own scales, and even if they no longer exist today, and have the potential to transform the urban space in which they are located. This study analyses the case of the Great Exhibition of 1851, in London, United Kingdom, which can be considered as the world’s first international event, and which played a significant role in the transformation of the Kensington site. Although the exhibition space itself was temporary, it transformed the Kensington site on which it was located at an urban scale. Even though these structures are time-limited projects, they transform the urban space where they are located. Here, the relationship between the exposition and the urban is associated with the raindrop analogies. Each raindrop will create its own circle when it reaches to an accumulation of water. The nature of the circle can be changed based on the size of the raindrops and different factors; in the case of expositions, the construction of the structure starts the process as a raindrop and creates its first circle. This circular effect occurs the bigger circles and reaches further distance at an urban scale, so this analogy gives the urban form even if the exposition has gone. This analogy is also valid for the urban transformation of the Kensington Site. This part of the London has changed following the reorganization and redesign after the exhibition was over, and the exposition space has developed into an integrated part of the city by taking on a set of additional functions, with the additional influence also of such neighbouring institutions as museums and later exhibition spaces. The site of the exposition has become a symbolic landscape of London and particularly the South Kensington has served as a great model to represent how international expositions can have a great contribution to change, transform and redesign the urban with a specific meaning: Exhibition.
description: International Planning History Society Proceedings, Vol. 17 No. 6 (2016): HISTORY URBANISM RESILIENCE: Scales and Systems
Serum IgG antibody responses to periodontal pathogens among pediatric subjects
Creators: name: Allen, Ronan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The first part of this thesis details the results from an observational study of 303 children 9-11 years of age. An immuno-checkerboard assay was used to analyze IgG levels for 18 different bacteria. Nearly half of the subjects tested positive for at least one orange complex bacteria and to A .actinomycetemcomitans. A higher proportion of females had positive IgG responses to 14 of the 18 bacteria. A significantly higher proportion of African Americans exhibited IgG responses for P. gingivalis, T. denticola, P. intermedia, P. nigrescens, A. actinomycetemcomitans and C. rectus (P<0.05). This cross sectional study indicates that a sizable proportion of young patients may be exposed and elicit an immune response to known periodontal pathogens. Recent evidence suggests that obesity and nutrition may be associated with periodontal disease. These two modifiable risk factors and their effects on periodontal disease are discussed in detail in the second part of this thesis.
The Life and Works of Professor Yorifusa Ishida (1932-2015): A Pioneer of Planning History in Japan
Creators: name: Watanabe, Shun-Ichi J.
Publisher: name: International Planning History Society Proceedings
Year: 2016

description: Professor Yorifusa Ishida (1932-2015), who was an IPHS council member, was one of the leading scholars in the research field of city planning in the post-war Japan. His research interest expands so widely to include planning system, planning history, land readjustment, building line, land use controls and planning, development profit, rural planning and citizen participation. He has publicized his research findings, practical proposals, and academic and political views in many books, articles and academic papers. It is rather unfortunate, however, that most of them are published in Japanese and so his attainments are not well known by scholars outside Japan with few exceptions. In this paper, we first trace his life as researcher and professor mainly at Tokyo Metropolitan University. Then we try to review as many academic writings of his as possible in a systematic way in order to analyze the development of his research interests and attainments in his academic carrier for over 40 years. This was made possible because we have obtained fairly detailed information of his curriculum vitae and his publications list thanks to his surviving family. In this analysis, we focus upon his attainments in planning history in particular. Our questions will include: (1) What is, in his framework and interest, the relationship between the research of planning history and that of city planning as a whole? (2) What are his specific and distinctive contributions in the field of planning history? (3) What is his view of planning history, which we need to analyze critically and may be able to learn form? (4) What is the impacts of the western (German, French, British and American) planning upon his research? In conclusion, we try to evaluate the roll of Professor Ishida in the entire history of city planning research in Japan.
description: International Planning History Society Proceedings, Vol. 17 No. 6 (2016): HISTORY URBANISM RESILIENCE: Scales and Systems
Development of a method for reliable power input measurements in conventional and single-use stirred bioreactors at laboratory scale
Creators: name: Kaiser, Stephan Christian
name: Werner, Sören
name: Jossen, Valentin
name: Kraume, Matthias
name: Eibl, Dieter
Publisher: name: Technische Universität Berlin
Year: 2017
Subjects: subject: 660 Chemische Verfahrenstechnik
subject: measurement
subject: power input
subject: single-use bioreactors
subject: Stirrers Torque

description: Power input is an important engineering and scale-up/down criterion in stirred bioreactors. However, reliably measuring power input in laboratory-scale systems is still challenging. Even though torque measurements have proven to be suitable in pilot scale systems, sensor accuracy, resolution, and errors from relatively high levels of friction inside bearings can become limiting factors at smaller scales. An experimental setup for power input measurements was developed in this study by focusing on stainless steel and single-use bioreactors in the single-digit volume range. The friction losses inside the air bearings were effectively reduced to less than 0.5% of themeasurement range of the torque meter. A comparison of dimensionless power numbers determined for a reference Rushton turbine stirrer (N-P = 4.17 +/- 0.14 for fully turbulent conditions) revealed good agreement with literature data. Hence, the power numbers of several reusable and single-use bioreactors could be determined over a wide range of Reynolds numbers between 100 and > 10(4). Power numbers of between 0.3 and 4.5 (for Re = 10(4)) were determined for the different systems. The rigid plastic vessels showed similar power characteristics to their reusable counterparts. Thus, it was demonstrated that the torque-based technique can be used to reliably measure power input in stirred reusable and single-use bioreactors at the laboratory scale.
Fiber optical parametric amplifiers in optical communication systems
Creators: name: Marhic, Michel E.
name: Andrekson, Peter A.
name: Petropoulos, Periklis
name: Radic, Stojan
name: Peucheret, Christophe
name: Jazayerifar, Mahmoud
Publisher: name: Technische Universität Berlin
Year: 2015
Subjects: subject: 530 Physik
subject: parametric amplifiers
subject: fiber optic communication
subject: fiber nonlinearities
subject: phase-sensitive amplification
subject: signal regeneration
subject: phase regeneration
subject: mid-span spectral inversion

description: The prospects for using fiber optical parametric amplifiers (OPAs) in optical communication systems are reviewed. Phase-insensitive amplifiers (PIAs) and phase-sensitive amplifiers (PSAs) are considered. Low-penalty amplification at/or near 1 Tb/s has been achieved, for both wavelength- and time-division multiplexed formats. High-quality mid-span spectral inversion has been demonstrated at 0.64 Tb/s, avoiding electronic dispersion compensation. All-optical amplitude regeneration of amplitude-modulated signals has been performed, while PSAs have been used to demonstrate phase regeneration of phase-modulated signals. A PSA with 1.1-dB noise figure has been demonstrated, and preliminary wavelength-division multiplexing experiments have been performed with PSAs. 512Gb/s have been transmitted over 6,000km by periodic phase conjugation. Simulations indicate that PIAs could reach data rate x reach products in excess of 14,000 Tb/s x km in realistic wavelength-division multiplexed long-haul networks. Technical challenges remaining to be addressed in order for fiber OPAs to become useful for long-haul communication networks are discussed.
Antibiotic Use for Treating Dental Infections in Children: A Survey of Dentists' Prescribing Practices
Creators: name: Cherry, William R.
Publisher: name: University of North Carolina at Chapel Hill
Year: 2011

description: Objective: To examine the antibiotic prescribing practices of general and pediatric dentists in the management of odontogenic infections in children. Design: We relied upon a cross-sectional study design to assess the antibiotic prescribing practices of general and pediatric dentists in North Carolina. The survey instrument consisted of five clinical case scenarios that included antibiotic-prescribing decisions in a self-completed questionnaire format consisting of Likert-type responses. The participants were volunteers attending one of four continuing education courses. All privately practicing pediatric dentists were invited to participate as were general practitioners who saw children in general practice. Practitioner responses on each clinical case were compared to the prescribing guidelines provided by the American Academy of Pediatric Dentistry and the American Dental Association. Results: The sample included 153 surveys (response rate: 55%). Of respondents, 67% (N=103) were general practitioners and 31% (n=48) were pediatric dentists. Antibiotics most commonly prescribed included Amoxicillin--67% (n=103) and Penicillin--31% (n=47). The frequency of prescribing antibiotics for odontogenic infections was daily--7% (n=11), weekly--34% (n=41), monthly-- 33% (n=51), or hardly ever--33% (n=50). For the 3 in-office case scenarios, adherence to guidelines was as follows: 11%, 26%, and 32%, respectively. For the 2 after-hours case scenarios, adherence dropped to 15% and 17%, respectively. Dentists who had completed post-graduate training were more likely (P<.05) to adhere to guidelines. No statistical difference was found between general and pediatric dentists. Conclusions: Adherence to professional guidelines for prescribing antibiotics for odontogenic infections in children was extremely low. There appears to be a lack of concordance between recommended professional guidelines and the antibiotic prescribing practices of dentists.
title: Bioenergy production and sustainable development
title: Science base for policymaking remains limited
titleType: Subtitle
Creators: name: Robledo-Abad, Carmenza
name: Althaus, Hans-Jörg
name: Berndes, Göran
name: Bolwig, Simon
name: Corbera, Esteve
name: Creutzig, Felix
name: Garcia-Ulloa, John
name: Geddes, Anna
name: Gregg, Jay S.
name: Haberl, Helmut
name: Hanger, Susanne
name: Harper, Richard J.
name: Hunsberger, Carol
name: Larsen, Rasmus K.
name: Lauk, Christian
name: Leitner, Stefan
name: Lilliestam, Johan
name: Lotze-Campen, Hermann
name: Muys, Bart
name: Nordborg, Maria
name: Ölund, Maria
name: Orlowsky, Boris
name: Popp, Alexander
name: Portugal-Pereira, Joana
name: Reinhard, Jürgen
name: Scheiffle, Lena
name: Smith, Pete
Publisher: name: Technische Universität Berlin
Year: 2017
Subjects: subject: 570 Biowissenschaften; Biologie
subject: agriculture
subject: bioenergy
subject: food security
subject: forestry
subject: mitigation
subject: sustainable development

description: The possibility of using bioenergy as a climate change mitigation measure has sparked a discussion of whether and how bioenergy production contributes to sustainable development. We undertook a systematic review of the scientific literature to illuminate this relationship and found a limited scientific basis for policymaking. Our results indicate that knowledge on the sustainable development impacts of bioenergy production is concentrated in a few well-studied countries, focuses on environmental and economic impacts, and mostly relates to dedicated agricultural biomass plantations. The scope and methodological approaches in studies differ widely and only a small share of the studies sufficiently reports on context and/or baseline conditions, which makes it difficult to get a general understanding of the attribution of impacts. Nevertheless, we identified regional patterns of positive or negative impacts for all categories - environmental, economic, institutional, social and technological. In general, economic and technological impacts were more frequently reported as positive, while social and environmental impacts were more frequently reported as negative (with the exception of impacts on direct substitution of GHG emission from fossil fuel). More focused and transparent research is needed to validate these patterns and develop a strong science underpinning for establishing policies and governance agreements that prevent/mitigate negative and promote positive impacts from bioenergy production.
Facing rapid urbanization: a century of East African Urbanism.
Creators: name: Frigerio, Alessandro
Publisher: name: International Planning History Society Proceedings
Year: 2016

description: East-Africa is one of the least urbanized regions in the world, but living one of the fastest urbanization. Its urban history has roots in the cosmopolitan Swahili culture and common experiences related to British and German colonialism and the East African Community. During the 20th century it has been a great laboratory regarding the effort of ordering growth according to very different political visions and social projects: almost everything has been tested in planning and urban design, with a relevant gradient of determinism in the designing efforts, from total to minimal. The East-Africans are excellent samples of contemporary metropolises facing the unstoppable proliferation of informal growth due to uncontrolled migrations and unsustainable development. Dar es Salaam, Nairobi, Mombasa, Kampala, Kigali and the metropolitan archipelago of Zanzibar have already passed the quota of a million inhabitants and the biggest cities are running million after million, with more than half of this growth occurring informally. From the beginning of their urban history all these cities have faced the issue of hosting different communities with different lifestyles, symbols, rituals, fears and public spaces. Their urban history is a telling overview on the relevance of urban architecture in determining their future. The paper proposes and overview on urban design and planning attempts over the last century proposing a periodization and investigating their influence in driving city growth and in contributing to city resilience through political and ecological changes.
description: International Planning History Society Proceedings, Vol. 17 No. 6 (2016): HISTORY URBANISM RESILIENCE: Scales and Systems
An Analysis of NCAA Division I Institution and Conference Senior Woman Administrators' Self-Perception and Career Intentions
Creators: name: Rippey, Jessica
Publisher: name: University of North Carolina at Chapel Hill Graduate School
Year: 2015
Subjects: Sports administration

description: In 1981, the National Collegiate Athletic Association (NCAA) mandated that member institutions designate the highest ranking female in the athletic department to be the Senior Woman Administrator (SWA) (Bower & Hums, 2013). Based on the research indicating inconsistency in the role of the SWA (Grappenddorf et al., 2008; Hatfield & Hatfield, 2009; Hoffman, 2010; Tiell et al., 2012) and the continuing underrepresentation of women in Athletics Director roles (Acosta and Carpenter, 2014), this study explored variables of the current landscape of the NCAA Division I Senior Woman Administrator, explore whether or not there are differences between NCAA DI competitive levels, and analyze differences in an SWA's desire to pursue a career as an Athletic Director based on a variety of experiential and psychological factors. This survey of over 350 NCAA Division I Senior Woman Administrators revealed that 61% of women with the SWA title have no desire to become an Athletic Director. Significant differences were found between the Football Bowl Subdivision and DI non-football competitive levels with regards to salary, number of mentors throughout career, and the current responsibilities of advocating issues important to both male and female student-athletes, coaches, and/or staff. The results of the study will add to literature and research examining the current state of the NCAA Division I Senior Woman Administrator title.
Improved determination of the $D \to K^-π^+π^+π^-$ coherence factor and associated hadronic parameters from a combination of $e^+e^-\to ψ(3770)\to c\bar{c}$ and $pp \to c \bar{c} X$ data
Creators: name: Evans, T.
name: Harnew, S. T.
name: Libby, J.
name: Malde, S.
name: Rademacker, J.
name: Wilkinson, G.
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Measurements of the coherence factor $R_{K3π}$, the average strong-phase difference $δ^{K3π}_D$ and mean amplitude ratio $r_D^{K3π}$ for the decay $D \to K^-π^+π^+π^-$ are presented. These parameters are important inputs to the determination of the unitarity triangle angle $γ$ in $B^- \to DK^-$ decays, where $D$ designates a superposition of $D^0$ and $\bar{D}{}^0$ mesons decaying to a common final state. The results are based on a combined fit to observables obtained from a re-analysis of the CLEO-c $ψ(3770)$ data set and those measured in a $D^0\bar{D}^0$ mixing study performed by the LHCb collaboration.
description: Error corrected in Eq.(5) and fit results relying on this expression updated. Typo corrected in Eq.(1) - no other consequences
Temporal urban studies framework; How much is done in Iran already ?
Creators: name: Chargboo, Nasibeh
Publisher: name: International Planning History Society Proceedings
Year: 2016

description: Temporal urban studies framework; How much is done in Iran already ? N. Charbgoo PhD Student, Iran University of Science and Technology, Tehran, Iran. Visiting Scholar, Department of Urbanism, Delft University of Technology,Delft, Netherlands. e-mail: n.charbgoo@tudelft.nl As the notions of place and planning have been changed in this era of globalization. It seems that it is inevitable for planners to change the way they look at and conceptualize places and the way they look at planning. According to this need, recent years have witnessed a burgeoning work on 'temporal approach on urban planning'. Temporal approach in planning thinking challenges by insisting on “spatial and temporal equity, temporal efficiency and such other concepts”. Clearly this approach brings about implication for a better and more temporally understanding of the existing condition, and a new approach to analyse, as it views the flows, the activities and the planning in a new light. This article particularly aims to determine an assessment framework in order to assess whether and to what extent temporal approach is embedded in existing urban comprehensive planning projects of Iran using a descriptive-analytical methodology. Basic attributes of time-oriented approach in planning have been extracted from the existing literature and combined in 'urban time studies framework'. We then traced urban time embeddedness in Iran comprehensive planning paradigm chronologically by applying this framework. Therefore, two resent Tehran comprehensive plan were chosen to be assessed against the proposed urban time studies framework. The results of the analysis indicate that all in all comprehensive planning system in Iran does not acquire or conform to an urban temporal studies framework, however there are some implicit cases of conformity consequently rendered as merely formalities, which deserve to be considered consciously and organized. However, comparing two cases as two stages in chronology of comprehensive planning revealed that in recent comprehensive plan of Tehran, temporal approaches is more considered in the form of temporal strategies.
description: International Planning History Society Proceedings, Vol. 17 No. 5 (2016): HISTORY URBANISM RESILIENCE: Historical Perspectives
Localized starbursts in dwarf galaxies produced by impact of low metallicity cosmic gas clouds
Creators: name: Almeida, J. Sanchez
name: Elmegreen, B. G.
name: Munoz-Tunon, C.
name: Elmegreen, D. M.
name: Perez-Montero, E.
name: Amorin, R.
name: Filho, M. E.
name: Ascasibar, Y.
name: Papaderos, P.
name: Vilchez, J. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Models of galaxy formation predict that gas accretion from the cosmic web is a primary driver of star formation over cosmic history. Except in very dense environments where galaxy mergers are also important, model galaxies feed from cold streams of gas from the web that penetrate their dark matter haloes. Although these predictions are unambiguous, the observational support has been indirect so far. Here we report spectroscopic evidence for this process in extremely metal-poor galaxies (XMPs) of the local Universe, taking the form of localized starbursts associated with gas having low metallicity. Detailed abundance analyses based on Gran Telescopio Canarias (GTC) optical spectra of ten XMPs show that the galaxy hosts have metallicities around 60 % solar on average, while the large star-forming regions that dominate their integrated light have low metallicities of some 6 % solar. Because gas mixes azimuthally in a rotation timescale (a few hundred Myr), the observed metallicity inhomogeneities are only possible if the metal-poor gas fell onto the disk recently. We analyze several possibilities for the origin of the metal-poor gas, favoring the metal-poor gas infall predicted by numerical models. If this interpretation is correct, XMPs trace the cosmic web gas in their surroundings, making them probes to examine its properties.
description: Accepted for publication in ApJL
Novel Therapeutic Strategies for the Treatment of Pulmonary Arterial Hypertension
Creators: name: Suen, Colin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: Pulmonary hypertension
Pulmonary arterial hypertension
Stem cell
Right ventricle
Endothelial progenitor cell
Endothelium
Heart failure
Sprague dawley rat
Fischer rat
Exosome
Microvesicle
Extracellular vesicles
SU5416
Paracrine
Angiogenesis
SUHx
Cardiotrophin
CT-1

description: Pulmonary arterial hypertension (PAH) is a progressive disease that results in increased pulmonary vasculature resistance, causing right ventricular (RV) remodeling, which eventually progresses into right heart failure and mortality. New and emerging therapeutic strategies involve regenerative approaches to repair the underlying vascular pathology using regenerative cell therapy and methods to alleviate RV dysfunction in the setting of fixed RV afterload. In the first section of the thesis, we investigated the role of EPC paracrine mechanisms in the treatment of PAH. We characterized the paracrine function of EPCs by demonstrating that EPC conditioned medium enhances endothelial cell migration, survival and angiogenesis in vitro. We further examined the role of secreted extracellular vesicles in the paracrine function of EPCs, which played a minor role in promoting wound healing. However, using the monocrotaline rat model of PAH, we did not demonstrate a consistent benefit on RV pressures or remodeling with EPCs or EPC conditioned medium. The lack of effect may be related to the advanced phenotype observed in our model of PAH. Survival in severe pulmonary arterial hypertension (PAH) is related to the ability of the right ventricle (RV) to adapt to increased afterload. Therefore, we explored the effect of genetic background on right ventricular adaptation and survival in a rat model of severe (PAH). Compared to the conventional Sprague-Dawley rat strain, we observed high mortality in the Fischer SUHx model of severe PAH. This was related to a strain-dependent failure of RV adaptation, as evidenced by RV dilatation, RV contractile dysfunction, decreased cardiac ouptut and decreased exercise capacity. Further analysis by gene expression microarrays and fluorescence microangiography demonstrate that failure of RV adaptation is due at least in part due to lack of adequate microvascular angiogenesis in the hypertrophied RV. This work lays the foundation for the section on RV-specific therapy that follows. Using the Fischer model of maladaptive RV remodeling, we tested whether cardiotrophin-1 (CT-1), a pro-angiogenic and cardioprotective cytokine, could improve RV adaptation. We demonstrated that as a rescue treatment, CT-1 reduced RV dilatation and function without influencing RV afterload, which suggests improved RV adaptation. These changes were associated with an increase in RV capillary density. As an early-stage preventative treatment, in addition to improving RV remodeling, CT-1 also reduced pulmonary pressures. These hemodynamic changes suggest that CT-1 may also have a direct impact on vascular tone or the underlying pulmonary vascular pathology.
ENSEMBLE Phase 3 Trial Sieve Analysis Statistical Analysis Plan
Creators: name: Gilbert, Peter B.
name: Rolland, Morgane
name: DeCamp, Allan
name: Juraska, Michal
name: Li, Li
name: Ludwig, James
name: Molitor, Cindy
name: Williamson, Brian
name: Hyrien, Ollivier
name: Benkeser, David
name: A. Magaret, Craig
Publisher: name: figshare
Year: 2023
Subjects: Biostatistics
Immunology not elsewhere classified
Infectious diseases

description: This SAP describes the statistical analyses for addressing the sieve analysis exploratory objective in the ENSEMBLE Phase 3 trial, a randomized, placebo-controlled COVID-19 vaccine effi?cacy trial: Exploratory Objective: To evaluate the genetic and/or phenotypic relationships of isolated SARS-CoV-2 strains to the vaccine sequence.
Geomorphic Consequences of Wave Climate Alteration Along Cuspate Coastlines
Creators: name: Johnson, Jennifer Mason
Publisher: name: University of North Carolina at Chapel Hill
Year: 2013

description: Cuspate coastlines are particularly sensitive to changes in wave climate and represent the best type of coastline for detecting initial responses to changing wave conditions. Previous work indicates that Capes Hatteras and Lookout in North Carolina--which are largely unaffected by shoreline stabilization efforts--have become increasingly asymmetric in shape in response to changes in Atlantic wave climate. Using shoreline change observations, nourishment data, wave climate data and model experiments, we find similar responses to wave climate change along Cape Fear, NC, discernible via temporal and spatial patterns of beach nourishment. Analyses of cuspate features in areas where the change in wave climate has been less pronounced (e.g., Fishing Point, MD & VA) or where local geology likely controls coastline shape (i.e., Cape Canaveral, FL), suggest that coastline shape changes in response to shifting wave climate are currently limited to sandy wave-dominated coastlines where wave climate changes are most pronounced.
The Vila Militar of Rio de Janeiro: the Genealogy of a Modern Design
Creators: name: Bonates, Mariana
name: Moreira, Fernando
Publisher: name: International Planning History Society Proceedings
Year: 2016

description: This paper investigates the principles that guided the design of the Vila Militar of Rio de Janeiro, a military town built in 1908. It is a narrative about the urban and architectural features of the pioneering military town in Brazil. Fruit of a Brazilian Army modernization program of the early twentieth century, this village was planned as the first autonomous unit, consisting of bureaucratic and residential buildings, military schools and training areas, in order to serve as a model to other military town to be built throughout the country, according to Frank McCann (2007). Designed in accordance with modern principles of circulation, hygiene, large green areas, zoning, standardization and easy reproducibility of forms, the blueprints reflected the corporate hierarchy in space and on the houses’ architecture. It means that, each rank was settled in different areas and with different types of housing but also different typologies was designed for the same rank offering a rich architectural landscape. In addition to the institution´s modernization, this settlement had a pedagogic function in introducing new notions of space and habitability and, moreover, it had a symbolic role of representing the officer’s emergence in the sociopolitical context of the First Republic. The officer´s houses in the Vila Militar breaks with the previous types of military housing from the 19th century. Although it was not effectively reproduced in other places as firstly intended, the construction of the Vila Militar still ensures its significance as a pioneering military living in the 20th century and due to its role as one of the main establishments of the corporation in Brazil. It is part of a building type with a striking presence in Brazilian cities landscapes along the 20th century. Finally, this paper strives to contribute with one more chapter of the history of Brazilian´s military town and, consequently, Brazilian´s history of urban and housing planning.
description: International Planning History Society Proceedings, Vol. 17 No. 5 (2016): HISTORY URBANISM RESILIENCE: Historical Perspectives
Visual Tracking of Deformation and Classification of Object Elasticity with Robotic Hand Probing
Creators: name: Hui, Fei
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: Fast level set method
Deformable objects
RGB-D imaging
Log-polar transform
Contour tracking
Elasticity classification
Point cloud clustering
Automatic color component selection

description: Performing tasks with a robotic hand often requires a complete knowledge of the manipulated object, including its properties (shape, rigidity, surface texture) and its location in the environment, in order to ensure safe and efficient manipulation. While well-established procedures exist for the manipulation of rigid objects, as well as several approaches for the manipulation of linear or planar deformable objects such as ropes or fabric, research addressing the characterization of deformable objects occupying a volume remains relatively limited. The fundamental objectives of this research are to track the deformation of non-rigid objects under robotic hand manipulation using RGB-D data, and to automatically classify deformable objects as either rigid, elastic, plastic, or elasto-plastic, based on the material they are made of, and to support recognition of the category of such objects through a robotic probing process in order to enhance manipulation capabilities. The goal is not to attempt to formally model the material of the object, but rather employ a data-driven approach to make decisions based on the observed properties of the object, capture implicitly its deformation behavior, and support adaptive control of a robotic hand for other research in the future. The proposed approach advantageously combines color image and point cloud processing techniques, and proposes a novel combination of the fast level set method with a log-polar mapping of the visual data to robustly detect and track the contour of a deformable object in a RGB-D data stream. Dynamic time warping is employed to characterize the object properties independently from the varying length of the detected contour as the object deforms. The research results demonstrate that a recognition rate over all categories of material of up to 98.3% is achieved based on the detected contour. When integrated in the control loop of a robotic hand, it can contribute to ensure stable grasp, and safe manipulation capability that will preserve the physical integrity of the object.
Transient one-dimensional diffusions conditioned to converge to a different limit point
Creators: name: Hening, Alexandru
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60J60

description: Let $(X_t)_{t\geq 0}$ be a regular one-dimensional diffusion that models a biological population. If one assumes that the population goes extinct in finite time it is natural to study the $Q$-process associated to $(X_t)_{t\geq 0}$. This is the process one gets by conditioning $(X_t)_{t\geq 0}$ to survive into the indefinite future. The motivation for this paper comes from looking at populations that are modeled by diffusions which do not go extinct in finite time but which go `extinct asymptotically' as $t\rightarrow \infty$. We look at transient one-dimensional diffusions $(X_t)_{t \geq 0}$ with state space $I=(\ell, \infty)$ such that $X_t\rightarrow \ell$ as $t\rightarrow \infty$, $\mathbb{P}^x$-almost surely for all $x\in I$. We `condition' $(X_t)_{t \geq 0}$ to go to $\infty$ as $t\rightarrow \infty$ and show that the resulting diffusion is the Doob $h$-transform of $(X_t)_{t\geq 0}$ with $h=s$ where $s$ is the scale function of $(X_t)_{t\geq 0}$. Finally, we explore what this conditioning does in two examples.
The founding and development of Louvain-la-Neuve, the only new town of Belgium
Creators: name: Laconte, Pierre
Publisher: name: International Planning History Society Proceedings
Year: 2016

description: SUMMARY OF FACTS The Louvain-la-Neuve new university town has been built by the University of Louvain on a previously agricultural and forested site of 920 ha, following a master plan drawn up by the “Groupe Urbanisme-Architecture” (R. Lemaire, J.-P. Blondel and P. Laconte). The first phase opened in 1972, comprising the science faculties, the science library (architect A. Jacqmain), student and commercial housing, shops and restaurants. Each phase was linked to the overall project and planned as a potentially multifunctional and autonomous unit along an east-west pedestrian spine. There has been direct rail access to Brussels since 1976. In 2005 a 35.000 m2 shopping centre opened next to the station (with 8 million visitors in 2014), which is to be extended above the railway tracks. The 2014 estimated daytime population of the new town was 45.000 (with 12.000 residents, out of 31.000 for the city of Ottignies-Louvain-la-Neuve). The land remains entirely in the university’s ownership and is developed through long term leases. OBJECTIVES OF THE PAPER. The proposed paper addresses the following research issues: 1. What skills were developed by “Groupe Urbanisme-Architecture” and its staff in order to conceive and create this new university town? How were they appointed? What was their urban model (one inspired by the mix of land uses found in historic towns, as opposed to the functionalist approach in which these are separated)? How was finance secured? How were the faculties involved in the implementation of the plan? How are the inhabitants and students involved? Could this experience inform present-day land use planning and urban design? 2. How did the1970 master plan adapt to change: e.g. in demography, in housing demand, in the university’s teaching and research needs and those of university-related industry, in the social, cultural and political environment, and from small individual plots to developer-led projects? 3. Which wider issues of planning research are raised by the Louvain example? These include: - the overall rationale for new town development, its up-front investment needs and its governance challenges (i.e. relations with existing local authorities). - the pros and cons of long-term leases as a tool for property development. - the economic and ecological justification of a linear pedestrian spine as a development model. This entails making vehicular traffic and parking accessible from the perimeter or putting it underground. - the economic and ecological justification for separating water treatment and storm water collection into a reservoir, treated as a lake whose depth varies according to the seasons. - the case for small plots and high density-low rise buildings versus large plots and high density-high rise. - the optimal location of the main squares and public spaces in a new town.
description: International Planning History Society Proceedings, Vol. 17 No. 5 (2016): HISTORY URBANISM RESILIENCE: Historical Perspectives
What's in a relationship?: testing theories of social capital using data from mentoring relationships
Creators: name: Gaddis, Steven Michael
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Using data from the Big Brothers/Big Sisters program, I test multiple theories of social capital to determine which aspects of social capital lead to greater educational outcomes in a dyadic relationship. The results indicate that time spent together is the most significant and positive indicator, and is moderated by racial homogeneity of the dyad.
A Historical Institutionalist Framework for European Spatial Planning
Creators: name: Faludi, Andreas
Publisher: name: International Planning History Society Proceedings
Year: 2016

description: Sorensen invokes historical institutionalism as a theoretical framework. This paper does so revisiting the making of the European Spatial Development Perspective of 1990s vintage and the subsequent Territorial Agenda of the European Union. The context is EU Cohesion policy. First the paper presents the theoretical framework. Then it explains why European spatial planning has been a limited success by identifying fault lines in the institutional architecture of European integration generally. The first concerns whether integration merely means states relinquishing specific powers, called competences in EU jargon, or rather whether the EU transcends states and state institutions. The second concerns whether representatives of state governments with their political and electoral concerns or the European Commission with its detached expertise should take the lead. The view that the EU has no business in planning because it is a power of the states has prevailed. To its chagrin, the Commission has also been side-lined by national planners. To overcome this problem, its idea was for the European Union to be given a competence, if not for spatial planning, then for territorial cohesion. When this came on the table, member states reconsidered their position. They adopted a Territorial Agenda of the European Union of their own. Neither their initiative nor the pursuit of territorial cohesion by the EU as such went far. Estimating that member states would not accept whatever it might propose in the matter, the Commission thus never took, as it could have done under there relevant rules an initiative in the matter. Instead it opted for a well-tried indirect approach, enlisting support from sub-national governments and also private actors. So, with its cross-border, transnational and interregional strands, ‘European territorial cooperation’ serves as a substitute for EU territorial cohesion policy proper. The paper explains the course of events over the more than twenty-five years covered by these developments by reference to the institutional architecture of the EU. The primacy which it gives to member states means that state institutions and their politics prevail over expertise, including that of planners. It also implies European space being conceptualised as a seamless cover of sovereign jurisdiction. But spatial planning within fixed borderlines flies into the face of a reality characterised by overlapping spatial networks. They cannot be contained, not even within the territory of the largest member state. So the story of European spatial planning casts a critical light on the EU institutional architecture being challenged by a fluid, dynamic spatial reality.
description: International Planning History Society Proceedings, Vol. 17 No. 5 (2016): HISTORY URBANISM RESILIENCE: Historical Perspectives
Light Bridge in a Developing Active Region. I. Observation of Light Bridge and its Dynamic Activity Phenomena
Creators: name: Toriumi, Shin
name: Katsukawa, Yukio
name: Cheung, Mark C. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Light bridges, the bright structures that divide the umbra of sunspots and pores into smaller pieces, are known to produce wide variety of activity events in solar active regions (ARs). It is also known that the light bridges appear in the assembling process of nascent sunspots. The ultimate goal of this series of papers is to reveal the nature of light bridges in developing ARs and the occurrence of activity events associated with the light bridge structures from both observational and numerical approaches. In this first paper, exploiting the observational data obtained by Hinode, IRIS, and Solar Dynamics Observatory (SDO), we investigate the detailed structure of the light bridge in NOAA AR 11974 and its dynamic activity phenomena. As a result, we find that the light bridge has a weak, horizontal magnetic field, which is transported from the interior by large-scale convective upflow and is surrounded by strong, vertical fields of adjacent pores. In the chromosphere above the bridge, a transient brightening occurs repeatedly and intermittently, followed by a recurrent dark surge ejection into higher altitudes. Our analysis indicates that the brightening is the plasma heating due to magnetic reconnection at lower altitudes, while the dark surge is the cool, dense plasma ejected from the reconnection region. From the observational results, we conclude that the dynamic activity observed in a light bridge structure such as chromospheric brightenings and dark surge ejections are driven by magnetoconvective evolution within the light bridge and its interaction with surrounding magnetic fields.
description: 38 pages, 9 figures, 1 table, accepted for publication in ApJ