cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Effects of a Web-Based Patient Decision Aid on Biologic and Small Molecule Agents for Rheumatoid Arthritis : Results From a Proof-of-Concept Study
Creators: name: Li, Linda C.
name: Shaw, Chris D.
name: Lacaille, Diane
name: Yacyshyn, Elaine
name: Jones, C. Allyson
name: Koehn, Cheryl
name: Hoens, Alison
name: Geldman, Jasmina
name: Sayre, E. C.
name: Macdonald, Graham G.
name: Leese, Jenny
name: Bansback, Nick
Publisher: name: Wiley Online Library
Year: 2021

description: Objective. To assess the extent to which ANSWER-2, an interactive online patient decision aid, reduces patients’ decisional conflict and improves their medication-related knowledge and self-management capacity. Methods. We used a pre–post study design. Eligible participants had a diagnosis of rheumatoid arthritis (RA), had been recommended to start using a biologic agent or small-molecule agent or to switch to a new one, and had internet access. Access to ANSWER-2 was provided immediately after enrollment. Outcome measures included 1) the Decisional Conflict Scale (DCS), 2) the Medication Education Impact Questionnaire (MeiQ), and 3) the Partners in Health Scale (PIHS). A paired t-test was used to assess differences pre and postintervention. Results. The majority of the 50 participants were women (n = 40), and the mean ± SD age of participants was 49.6 ± 12.2 years. The median disease duration was 5 years (25th, 75th percentile: 2, 10 years). The mean ± SD DCS score was 45.9 ± 25.1 preintervention and 25.1 ± 21.8 postintervention (mean change of -21.2 of 100 [95% confidence interval (95% CI) -28.1, -14.4], P < 0.001). Before using ANSWER-2, 20% of participants had a DCS score of <25, compared to 52% of participants after the intervention. Similar results were observed in the PIHS (mean ± SD 25.3 ± 14.8 preintervention and 20.4 ± 13.0 postintervention; mean change of -3.7 of 88 [95% CI -6.3, -1.0], P = 0.009). Findings from the MeiQ were mixed, with statistically significant differences found only in the selfmanagement subscales. Conclusion. Patients’ decisional conflict decreased and perceived self-management capacity improved after using ANSWER-2. Future research comparing the effectiveness of ANSWER-2 with that of educational material on biologic agents will provide further insight into its value in RA management.
Global Genetic Variations Predict Brain Response to Faces
Creators: name: Dickie, Erin W.
name: Tahmasebi, Amir
name: French, Leon
name: Kovacevic, Natasa
name: Banaschewski, Tobias
name: Barker, Gareth J.
name: Bokde, Arun
name: Büchel, Christian
name: Conrod, Patricia
name: Flor, Herta
name: Garavan, Hugh
name: Gallinat, Juergen
name: Gowland, Penny
name: Heinz, Andreas
name: Ittermann, Bernd
name: Lawrence, Claire
name: Mann, Karl
name: Martinot, Jean-Luc
name: Nees, Frauke
name: Nichols, Thomas
name: Lathrop, Mark
name: Loth, Eva
name: Pausova, Zdenka
name: Rietschel, Marcela
name: Smolka, Michal N.
name: Ströhle, Andreas
name: Toro, Roberto
name: Schumann, Gunter
name: Paus, Tomas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::576 Genetik und Evolution

description: Face expressions are a rich source of social signals. Here we estimated the proportion of phenotypic variance in the brain response to facial expressions explained by common genetic variance captured by ~500,000 single nucleotide polymorphisms. Using genomic-relationship-matrix restricted maximum likelihood (GREML), we related this global genetic variance to that in the brain response to facial expressions, as assessed with functional magnetic resonance imaging (fMRI) in a community-based sample of adolescents (n = 1,620). Brain response to facial expressions was measured in 25 regions constituting a face network, as defined previously. In 9 out of these 25 regions, common genetic variance explained a significant proportion of phenotypic variance (40–50%) in their response to ambiguous facial expressions; this was not the case for angry facial expressions. Across the network, the strength of the genotype-phenotype relationship varied as a function of the inter-individual variability in the number of functional connections possessed by a given region (R2 = 0.38, p<0.001). Furthermore, this variability showed an inverted U relationship with both the number of observed connections (R2 = 0.48, p<0.001) and the magnitude of brain response (R2 = 0.32, p<0.001). Thus, a significant proportion of the brain response to facial expressions is predicted by common genetic variance in a subset of regions constituting the face network. These regions show the highest inter-individual variability in the number of connections with other network nodes, suggesting that the genetic model captures variations across the adolescent brains in co-opting these regions into the face network.
Mutational analysis of mammalian ubiquitin
Creators: name: Tsirigotis, Maria
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Chemistry, Biochemistry.

description: Much of what is known about the ubiquitin/proteasome pathway has been deduced from mutational analysis performed in the yeast model system. From the high level of conservation between yeast and mammalian ubiquitin it would be expected that expression of analogous ubiquitin isoforms in higher eukaryotes would result in similar phenotypes. A site directed mutagenesis approach was employed to investigate the phenotypes of expression of mutant ubiquitin in higher eukaryotes and in the in vivo setting of novel ubiquitin transgenic mice. It was found that Ub-EGFP fusion proteins are efficiently recognized and processed by ubiquitin specific proteases both in mammalian cells and in transgenic mice; the transgene-derived ubiquitin moiety was found to substitute for endogenous ubiquitin in poly-Ub chain assembly and ubiquitinated conjugates were recovered using standard purification methodologies. The expression of chain-terminating ubiquitin derivatives (K48R and K63R) predisposed cells to the toxic effects of misfolded proteins and sensitized cells to DNA damaging agents. In transgenic mice, the expression of K48R mutant ubiquitin was found to confer protective effects and delay the deterioration of Purkinje neurons in a mouse model of SCA-1. The neuroprotective effect of K48R mutant ubiquitin may be mediated though stabilization of key transcription factors whose loss figured in the normal course of the SCA1 disease. The expression of C-terminal variants in yeast has been proposed to have profound effects on ubiquitin metabolism. A mechanistically related mechanism has been proposed to contribute to the pathogenesis of Alzheimer's disease wherein transcriptional frameshifting of the ubiquitin B mRNA generates an aberrant ubiquitin protein (termed UBB+1) with an altered C-terminus. To investigate the constraints with regard to processing/conjugation and recycling of ubiquitin in higher eukaryotes a plethora of C-terminal ubiquitin variants were generated and introduced in mammalian cells as linear fusions with EGFP. Mutations that inactivate yeast ubiquitin did not abolish the function of ubiquitin in higher eukaryotes; C-terminal ubiquitin variants were processed by deubiquitinating enzymes and in some cases were found to conjugate to cellular proteins. The tolerance of mammalian cells to mutant ubiquitin may be attributable to loosened constraints that exist at the C-terminus due to mechanisms that couple deubiquitination, targeting and destruction of Ub-EGFP fusion proteins. Preliminary data suggest that prolonged exposure of cells of neuronal lineage to C-terminal ubiquitin variant as assessed in transgenic mice may result in perturbed ubiquitin homeostasis, a feature observed in the pathogenesis of Alzheimer's disease.
An orchestrated survey of methodologies for automated software test case generation
Creators: name: Anand, Saswat
name: Burke, Edmund K.
name: Chen, Tsong
name: Clark, John
name: Cohen, Myra B.
name: Grieskamp, Wolfgang
name: Harman, Mark
name: Harrold, Mary Jean
name: McMinn, Phil
name: Bertolino, Antonia
name: Li, Jianhua
name: Zhu, H.
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 461201
subject: Automated software engineering
classificationCode: 461202
subject: Empirical software engineering

description: Test case generation is among the most labour-intensive tasks in software testing. It also has a strong impact on the effectiveness and efficiency of software testing. For these reasons, it has been one of the most active research topics in software testing for several decades, resulting in many different approaches and tools. This paper presents an orchestrated survey of the most prominent techniques for automatic generation of software test cases, reviewed in self-standing sections. The techniques presented include: (a) structural testing using symbolic execution, (b) model-based testing, (c) combinatorial testing, (d) random testing and its variant of adaptive random testing, and (e) search-based testing. Each section is contributed by world-renowned active researchers on the technique, and briefly covers the basic ideas underlying the method, the current state of the art, a discussion of the open research problems, and a perspective of the future development of the approach. As a whole, the paper aims at giving an introductory, up-to-date and (relatively) short overview of research in automatic test case generation, while ensuring a comprehensive and authoritative treatment.
Algorithms for survivable routing and wavelength assignment in WDM wavelength-routed mesh networks
Creators: name: Eshoul, AbdElhamid Eswei
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Engineering, Electronics and Electrical.

description: Due to the huge amount of data that can be lost and the large number of users that can be disrupted during the times of failure in wavelength division multiplexing (WDM) optical networks, reliable optical layer that can quickly and efficiently respond to failures such as fiber cuts is a critical issue to users and service providers. The major challenge in survivable mesh networks is the design of resource allocation algorithms that allocate network resources efficiently while at the same time are able to recover from a failure quickly. This issue is particularly more challenging in optical networks operating under wavelength continuity constraint, where the same wavelength must be assigned on all links in the selected path. This thesis presents a number of schemes to solve the problem of survivable routing and wavelength assignment (RWA) in wavelength-routed WDM networks. The focus is on developing algorithms for survivable RWA in mesh networks that address both resource efficiency and restoration speed under static and dynamic traffic environments. Two different approaches (diverse routing and p-cycles) are pursued to solve the problem of survivable RWA. Their performances and complexities are also compared. Under static traffic, new algorithms have been developed to formulate the RWA as an Integer Linear programming problem using both diverse routing and p-cycles. Under dynamic traffic, new heuristic algorithms are developed to solve the survivable RWA using both approaches and their performances are evaluated and compared using simulations.
Predicting aircraft noise with AZB 2.0 - a best practice model being revised
Creators: name: Bopst, Juliane
Publisher: name: My University
Year: 2019

description: The German aircraft noise calculation model AzB (Anleitung zur Berechnung von Lärmschutzbereichen) has been developed for defining noise protection areas by assessing the noise of a predicted air traffic scenario. The AzB data base was specially designed for this purpose and it consists of 36 aircraft classes comprising civil and military jet aircraft as well as propeller-driven aircraft and helicopters. In the last decades the traffic mix has changed considerably. The share of aircraft complying with ICAO Annex 16, chapter 3 in the total air traffic volume has â€Ìat least in Germany - almost fallen to zero, whereas several aircraft with significantly lower noise emissions have been put into service. Advances in noise mitigation have also been achieved due to optimized flight operations (noise abatement departure procedures suiting to population structure, CDO, steeper approach...) Although parts of the AzB were revised and amended in 2006/2007 , its data base corresponds essentially to that published by the German Environment Agency (UBA) in 1999. The acoustic and operational data of the AzB are of limited suitability as a means of representing new and prospective aircraft types. To meet the requirements for accuracy and to achieve good accordance with measurements, the German Aerospace Center (DLR) is updating the data base of the AzB on behalf of the German Environment Agency. In this contribution an overview of the recent developments is given and first results of the research project are presented. Quelle: https://icsv26.sched.com
title: Synergistic Strategy for Multicolor Two-photon Microscopy
title: Application to the Analysis of Germinal Center Reactions In Vivo
titleType: Subtitle
Creators: name: Rakhymzhan, Asylkhan
name: Leben, Ruth
name: Zimmermann, Hanna
name: Günther, Robert
name: Mex, Peggy
name: Reismann, David
name: Ulbricht, Carolin
name: Acs, Andreas
name: Brandt, Alexander U.
name: Lindquist, Randall L.
name: Winkler, Thomas H.
name: Hauser, Anja E.
name: Niesner, Raluca A.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Biological fluorescence
subject: Imaging the immune system
subject: Mode-locked lasers
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Simultaneous detection of multiple cellular and molecular players in their native environment, one of the keys to a full understanding of immune processes, remains challenging for in vivo microscopy. Here, we present a synergistic strategy for spectrally multiplexed in vivo imaging composed of (i) triple two-photon excitation using spatiotemporal synchronization of two femtosecond lasers, (ii) a broad set of fluorophores with emission ranging from blue to near infrared, (iii) an effective spectral unmixing algorithm. Using our approach, we simultaneously excite and detect seven fluorophores expressed in distinct cellular and tissue compartments, plus second harmonics generation from collagen fibers in lymph nodes. This enables us to visualize the dynamic interplay of all the central cellular players during germinal center reactions. While current in vivo imaging typically enables recording the dynamics of 4 tissue components at a time, our strategy allows a more comprehensive analysis of cellular dynamics involving 8 single-labeled compartments. It enables to investigate the orchestration of multiple cellular subsets determining tissue function, thus, opening the way for a mechanistic understanding of complex pathophysiologic processes in vivo. In the future, the design of transgenic mice combining a larger spectrum of fluorescent proteins will reveal the full potential of our method.
AGN feedback driven molecular outflow in NGC 1266
Creators: name: Alatalo, K.
name: Nyland, K. E.
name: Graves, G.
name: Deustua, S.
name: Wrobel, J.
name: Young, L. M.
name: Davis, Timothy
name: Bureau, M.
name: Bayet, E.
name: Blitz, L.
name: Bois, M.
name: Bournaud, F.
name: Cappellari, M.
name: Davies, R. L.
name: De Zeeuw, P. T.
name: Emsellem, E.
name: Khochfar, S.
name: Krajnovic, D.
name: Kuntschner, H.
name: Martín, S.
name: McDermid, R. M.
name: Morganti, R.
name: Naab, T.
name: Sarzi, M.
name: Scott, N.
name: Serra, P.
name: Weijmans, A.
Publisher: name: Swinburne
Year: 2024

description: NGC 1266 is a nearby field galaxy observed as part of the ATLAS3D survey (Cappellari et al. 2011). NGC 1266 has been shown to host a compact (< 200 pc) molecular disk and a mass-loaded molecular outflow driven by the AGN (Alatalo et al. 2011). Very Long Basline Array (VLBA) observations at 1.65 GHz revealed a compact (diameter < 1.2 pc), high brightness temperature continuum source most consistent with a low-level AGN origin. The VLBA continuum source is positioned at the center of the molecular disk and may be responsible for the expulsion of molecular gas in NGC 1266. Thus, the candidate AGN-driven molecular outflow in NGC 1266 supports the picture in which AGNs do play a significant role in the quenching of star formation and ultimately the evolution of the red sequence of galaxies.
The permeability of a lipid bilayer
Creators: name: Gauthier, Alain R
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Physics, General.

description: This work presents results on the permeability of a lipid bilayer to water molecules. We look at the change in bilayer permeability as a function of lipid structure and area per lipid molecule. A molecular dynamic simulation (MDS) of a solvent surfactant system was used in the canonical ensemble to simulate the membranes. Permeability was obtained by calculating the permeative resistance. This method, developed by Marrink and Berendsen, allows the sampling of very long time scale events on short time scale simulations. The structural properties of the simulated bilayer are studied and compared both to atomistic MDS and experiments. The elasticity of the simulated membranes are shown to be in good agreement with experimental results. The permeation is found to increase only slightly for a relative stretch of up to 20%, a result which is qualitatively similar to recent experiments. The increase is described by a linear relation between the permeability and the relative extension. Most of the changes in the lipid bilayer are found to occur in the central part near the ends of the tails. The effect of lipid packing on bilayer permeability are also discussed.
3657404.pdf
Creators: name: Peters, Vanessa
name: Faruk, Omar
name: Asane, Joshua
name: Alexander, Rohan
name: Peters, D'Angelo
name: Prayakarao, Srujana
name: Rout, Sangeeta
name: Noginov, Mikhail
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement document
The gift of health: Cuban medical cooperation in Kiribati
Creators: name: McLennan, Sharon
name: Werle, Cristine
name: Leslie, Helen
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2025

description: Since 2006, 33 I-Kiribati students have undertaken medical education in Cuba and returned home as doctors, but little is known about how they translate the Cuban preventive model of care to medical practice in the Pacific context. The research addresses this gap through qualitative fieldwork in South Tarawa and reveals that the assimilation of Cuban-trained doctors into medical practice is complicated by challenges related to clinical skills, language and contextual knowledge. These challenges have been successfully addressed with the development of the Kiribati Internship Training Programme but a misalignment between the prevention-focussed medicine taught in Cuba, and the curative orientation of the Kiribati health system and internship programme remains a concern, and the graduates’ knowledge and experience of primary and preventative care is not yet well utilised. This paper argues that the challenge now is to ensure that the knowledge and skills gained by the Cuban graduates at all steps of this journey are utilised in order to bring better health outcomes for the people of Kiribati.
3657404.pdf
Creators: name: Peters, Vanessa
name: Faruk, Omar
name: Asane, Joshua
name: Alexander, Rohan
name: Peters, D'Angelo
name: Prayakarao, Srujana
name: Rout, Sangeeta
name: Noginov, Mikhail
Publisher: name: Optica Publishing Group
Year: 2019
Subjects: Uncategorized

description: Supplement document
Characterizing undiagnosed chronic obstructive pulmonary disease: a systematic review and meta-analysis
Creators: name: Johnson, Kate M
name: Bryan, Stirling
name: Ghanbarian, Shahzad
name: Sin, Don D
name: Sadatsafavi, Mohsen
Publisher: name: BioMed Central
Year: 2018

description: Background: A significant proportion of patients with chronic obstructive pulmonary disease (COPD) remain undiagnosed. Characterizing these patients can increase our understanding of the ‘hidden’ burden of COPD and the effectiveness of case detection interventions. Methods: We conducted a systematic review and meta-analysis to compare patient and disease factors between patients with undiagnosed persistent airflow limitation and those with diagnosed COPD. We searched MEDLINE and EMBASE for observational studies of adult patients meeting accepted spirometric definitions of COPD. We extracted and pooled summary data on the proportion or mean of each risk factor among diagnosed and undiagnosed patients (unadjusted analysis), and coefficients for the adjusted association between risk factors and diagnosis status (adjusted analysis). Results: Two thousand eighty-three records were identified through database searching and 16 articles were used in the meta-analyses. Diagnosed patients were less likely to have mild (v. moderate to very severe) COPD (odds ratio [OR] 0.30, 95%CI 0.24–0.37, 6 studies) in unadjusted analysis. This association remained significant but its strength was attenuated in the adjusted analysis (OR 0.72, 95%CI 0.58–0.89, 2 studies). Diagnosed patients were more likely to report respiratory symptoms such as wheezing (OR 3.51, 95%CI 2.19–5.63, 3 studies) and phlegm (OR 2.16, 95% CI 1.38–3.38, 3 studies), had more severe dyspnea (mean difference in modified Medical Research Council scale 0.52, 95%CI 0.40–0.64, 3 studies), and slightly greater smoking history than undiagnosed patients. Patient age, sex, current smoking status, and the presence of coughing were not associated with a previous diagnosis. Conclusions: Undiagnosed patients had less severe airflow obstruction and fewer respiratory symptoms than diagnosed patients. The lower disease burden in undiagnosed patients may significantly delay the diagnosis of COPD.
Testing the notion of continuity between waking experience and REM dream content.
Creators: name: Roussy, Francine.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Psychology, Cognitive.

description: In 1996, Roussy et al. reported a study which failed to demonstrate the predictability of REM dream content from presleep ideation. The current study was designed to further test this predictability by using a larger sample of REM dream content and waking ideation. Thirteen young-adult female university students reported three REM dreams on each of four laboratory nights spaced at weekly intervals. On two of the study days, waking Thought Samples (TS) were recorded by participants at five randomly selected times. On the two other days, participants recorded their five most Significant Concerns (SC) prior to going to sleep at the laboratory. In a within-participant ranking task, two student peers had to read each item which consisted of the waking ideation sample for one night (WI) for one participant and the four dream sets (DS) for this same participant. Their task for each of these items was to rank the 4 DS from 1 to 4 as they believed them to be most likely related to the WI (rank 1) or least likely related to the WI (rank 4). For this task, there were two items for each of 12 participants. It was hypothesized that a dream set would receive a rank closer to 1 when it was the target than when it served as a foil. In a within-participant matching task, ten student peers were given the 4 dream sets and 4 waking ideation samples separately for each participant. Judges were asked to match each DS with one of the WI, thus making 4 pairs. In the between-participant matching task, these same ten judges were given 12 items. For each item, they were asked to match 4 dream sets from different participants with their corresponding waking ideation samples. For the ranking task, a three-way mixed ANOVA (2 judges - between, 2 waking ideation conditions: TS & SC - within, 2 dream conditions: target & nontarget - within) revealed that there were no significant differences between ranks given to target or foil dreams, and this in both the TS and SC conditions, as well as by both judges. Chi-square values for both the within- and between-participant matching task were not significant (.047 and .096 respectively, p < .99). The observed number of matches was therefore not significantly different from what was expected by chance. These results are consistent with those of our earlier study and suggest that it is not possible for non-clinically trained judges to match REM dream content with waking ideation. Further analyses conducted with a clinical psychologist serving as judge demonstrated that she was also unable to complete the tasks at greater than chance levels. It therefore seems that the relationship between waking and dreaming is not as obvious and predictable as has been believed. Rather, this study supports the cognitive position that dreams appear to randomly integrate elements from waking life and do not seem to give priority to immediately preceding experiences and concerns.
title: Everolimus in metastatic renal cell carcinoma after failure of initial anti–VEGF therapy
title: final results of a noninterventional study
titleType: Subtitle
Creators: name: Bergmann, Lothar
name: Kube, Ulrich
name: Doehn, Christian
name: Steiner, Thomas
name: Goebell, Peter J.
name: Kindler, Manfred
name: Herrmann, Edwin
name: Janssen, Jan
name: Weikert, Steffen
name: Scheffler, Michael T.
name: Schmitz, Joerg
name: Albrecht, Michael
name: Staehler, Michael
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Data are limited regarding routine use of everolimus after initial vascular endothelial growth factor (VEGF)–targeted therapy. The aim of this prospective, noninterventional, observational study was to assess efficacy and safety of everolimus after initial VEGF-targeted treatment in patients with metastatic renal cell carcinoma (mRCC) in routine clinical settings. Methods Everolimus was administered per routine clinical practice. Patients with mRCC of any histology from 116 active sites in Germany were included. The main objective was to determine everolimus efficacy in time to progression (TTP). Progression-free survival (PFS), treatment duration, tumor response, adherence to everolimus regimen, treatment after everolimus, and safety were also assessed. Results In the total population (N = 334), median follow-up was 5.2 months (range, 0–32 months). Median treatment duration (safety population, n = 318) was 6.5 months (95% confidence interval [CI], 5–8 months). Median TTP and median PFS were similar in populations investigated. In patients who received everolimus as second-line treatment (n = 211), median (95% CI) TTP was 7.1 months (5–9 months) and median PFS was 6.9 months (5–9 months). Commonly reported adverse events (safety population, n = 318) were dyspnea (17%), anemia (15%), and fatigue (12%). Limitations of the noninterventional design should be considered. Conclusions This study reflects routine clinical use of everolimus in a large sample of patients with mRCC. Favorable efficacy and safety were seen for everolimus after previous therapy with one VEGF-targeted agent. Results of this study confirm everolimus as one of the standard options in second-line therapy for patients with mRCC. Novartis study code, CRAD001LD27: VFA registry for noninterventional studies (http://www.vfa.de/de/forschung/nisdb/ webcite).
title: COMPARATIVE EFFECTS OF LOW- AND HIGH- TECH VISUAL ACTIVITY SCHEDULES ON TRANSITION LATENCY IN YOUNG CHILDREN WITH AUTISM
Creators: name: Mikayla Nelson
Publisher: name: University of Kentucky Libraries
Year: 2025
Subjects: classificationCode: 5.3
subject: FOS: Educational sciences

description: Low-technology (low-tech) and high-technology (high-tech) visual activity schedules (VAS) were implemented for transitions with three kindergarten males diagnosed with autism spectrum disorder (ASD). An alternating treatment design was used to compare the latency of transitions from a preferred activity to an academic task after presenting a low- or high-tech VAS. Results indicated different effects between participants. Low-tech VAS was effective for one participant, and high-tech VAS was not effective for any participants in this study. Implications and further research are discussed regarding the importance of creating VAS on an individual basis, ensuring that each VAS meets an individual's communication and behavioral needs.
description: © 2025 Mikayla Nelson
Revealing the origin of the cold ISM in massive early-type galaxies
Creators: name: Davis, Timothy
name: Alatalo, K.
name: Bureau, M.
name: Young, L.
name: Blitz, L.
name: Crocker, A.
name: Bayet, E.
name: Bois, M.
name: Bournaud, F.
name: Cappellari, M.
name: Davies, Roger L.
name: Duc, P. A.
name: De Zeeuw, P. T.
name: Emsellem, E.
name: Falcon-Barroso, J.
name: Khochfar, S.
name: Krajnovic, D.
name: Kuntschner, H.
name: Lablanche, P. Y.
name: McDermid, R. M.
name: Morganti, R.
name: Naab, T.
name: Sarzi, M.
name: Scott, N.
name: Serra, P.
name: Weijmans, A.
Publisher: name: Swinburne
Year: 2024

description: Recently, massive early-type galaxies have shed their red-and-dead moniker, thanks to the discovery that many host residual star formation. As part of the ATLAS-3D project, we have conducted a complete, volume-limited survey of the molecular gas in 260 local early-type galaxies with the IRAM-30m telescope and the CARMA interferometer, in an attempt to understand the fuel powering this star formation. We find that around 22% of early-type galaxies in the local volume host molecular gas reservoirs. This detection rate is independent of galaxy luminosity and environment. Here we focus on how kinematic misalignment measurements and gas-to-dust ratios can be used to put constraints on the origin of the cold ISM in these systems. The origin of the cold ISM seems to depend strongly on environment, with misaligned, dust poor gas (indicative of externally acquired material) being common in the field but completely absent in rich groups and in the Virgo cluster. Very massive galaxies also appear to be devoid of accreted gas. This suggests that in the field mergers and/or cold gas accretion dominate the gas supply, while in clusters internal secular processes become more important. This implies that environment has a strong impact on the cold gas properties of ETGs.
L'expérience de la souffrance auprès de femmes atteintes d'un cancer du sein d'un stade avancé.
Creators: name: Perreault, Annie.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Health Sciences, Nursing.

description: Cette étude phénoménologique Heideggerienne vise à explorer et à décrire l'expérience de la souffrance et de la détresse spirituelle telles que vécues par des femmes atteintes d'un cancer du sein. L'échantillon se compose de six femmes sélectionnées dans un centre de cancérologie. Une entrevue servi-structurée a été réalisée auprès des participantes et les transcriptions verbatims ont constitué les données de ce projet de recherche. D'une part, la multidimentionnalité de la souffrance provoque de multiples pertes qui amène la destruction de l'entièreté de la femme. D'autre part, en réponse à l'expérience de la souffrance, les résultats d'analyse révèlent l'existence d'un processus dynamique de guérison en profondeur de nature spirituelle. Le cheminement évolue selon le cycle des cinq saisons de l'Arbre de Vie qui représente les différentes phases à compléter: (1) signal d'alarme; (2) perte; (3) métamorphose; (4) travail à accomplir et (5) guérison en profondeur. Des éléments clés tels que les réactions à la maladie, le soutien, l'espoir, le travail sur soi et la recherche de sens, favorisent le parachèvement de ce travail personnel menant vers la réconciliation de soi. La pierre angulaire de ce processus est une transformation intérieure qui implique une impression d'être accompagné par une présence supra-moi. De nombreuses implications pour les soins infirmiers découlent des résultats de cette étude ainsi que des pistes de recherche futures à réaliser auprès de femmes atteintes d'un cancer du sein.
On the (new) New Zealand graduated response law (and why it’s unlikely to achieve its aims)
Creators: name: Giblin, Rebecca
Publisher: name: Swinburne
Year: 2024

description: In 2011 New Zealand controversially introduced a 'three strikes' graduated response law. Under this law, the holders of Internet service accounts which are detected as having infringed copyright via P2P file sharing technologies three times within a specified time period can be ordered by the Copyright Tribunal to pay content owners up to NZ$15,000. The law also provides for Internet access to be suspended, though these provisions are currently inactive pending determination of the efficacy of the financial penalty regime. This paper explores the contours of the NZ graduated response regime - and then outlines a number of technical and practical reasons why it's unlikely to achieve its aims.
Eligibility for heroin-assisted treatment (HAT) among people who inject opioids and are living with HIV in a Canadian setting
Creators: name: Klimas, Jan
name: Dong, Huiru
name: Fairbairn, Nadia
name: Socias, M. Eugenia
name: Barrios, Rolando
name: Wood, Evan
name: Kerr, Thomas
name: Montaner, Julio
name: Milloy, M-J
Publisher: name: BioMed Central
Year: 2018

description: Objectives: A growing body of evidence supports the effectiveness of injectable diacetylmorphine (i.e., heroin) for individuals with treatment-refractory opioid use disorder. Despite this evidence, and the increasing toll of opioid-associated morbidity and mortality, it remains controversial in some settings. To investigate the possible contribution of heroin-assisted treatment (HAT) to HIV treatment-related outcomes, we sought to estimate the proportion and characteristics of HIV-positive people who inject opioids that might be eligible for HAT in Vancouver, Canada. Methods: We used data from a prospective cohort of people living with HIV who use illicit drugs in Vancouver, Canada. Using generalized estimating equations (GEE), we assessed the longitudinal relationships between eligibility for HAT, using criteria from previous clinical trials and guidelines, with behavioural, social, and clinical characteristics. Results: Between 2005 and 2014, 478 participants were included in these analyses, contributing 1927 person-years of observation. Of those, 94 (19.7%) met eligibility for HAT at least once during the study period. In a multivariable GEE model, after adjusting for clinical characteristics, being eligible for HAT was positively associated with homelessness, female gender, high-intensity illicit drug use, drug dealing and higher CD4 count. Conclusions: In our study of HIV-positive people with a history of injection drug use, approximately 20% of participants were eligible for HAT at ≥ 1 follow-up period. Eligibility was linked to risk factors for sub-optimal HIV/AIDS treatment outcomes, such as homelessness and involvement in the local illicit drug trade, suggesting that scaling-up access to HAT might contribute to achieving optimal HIV treatment in this setting.
Second language acquisition of Chinese directional complement constructions under usage-based approaches
Creators: name: He, Xue
Publisher: name: University of Iowa
Year: 2022
Subjects: Chinese directional complements
Chinese grammar acquisition
public abstract

description: Multiword sequences, as important building blocks for language learning, pose difficulty for second language (L2) learners (Arnon & Christiansen, 2017; Christiansen & Arnon, 2017). Chinese directional complement (DC) constructions, as a subtype of Chinese multiword sequences, are challenging to acquire for L2 learners (Wu, 2011; Yang, 2003). However, little is known about L2 Chinese learners’ acquisition of figurative DCs and their comprehension of literal and figurative DCs. The present study investigated whether L2 learners’ acquisition of Chinese DCs was influenced by the syntactic and semantic complexity of DC constructions, and learners’ experience with their first language (L1), through a situation-cued sentence completion test, grammaticality judgment test, and post-test interview. Analysis of 103 Chinese learners’ performance on the two tests and 16 learners’ perspectives in the interviews revealed that learners’ acquisition of DCs was affected by the syntactic complexity of DC constructions and whether DCs were used literally or figuratively. Results showed that the syntactic constraint of DC constructions and word order associated with compound DC constructions with noun phrases presented difficulty for learners. Figurative DCs were found to be challenging, but the difficulty of figurative compound DCs was mitigated by learners’ acquisition of figurative compound DC constructions as coherent lexical chunks. Additionally, it was found that L1 experience of English learners of Chinese influenced their comprehension and production of DCs. Lái (来hither) or qù (去thither) as the second DC in compound DC constructions with noun phrases was overshadowed or even blocked by cues learners were more familiar with in their L1, and the learning of one-to-two form-function mapping of lái (来hither) and qù (去thither) was interfered with by the one-to-one mapping of “come” and “go” in English, which are the equivalent words for lái (来hither) and qù (去thither) as verbs. Finally, it was revealed that heritage language learners outperformed non-heritage language learners on both tests, which can be explained by heritage language learners’ exposure to Chinese at home and their familiarity with Chinese aural input.
description: The results of the current study have implications for teaching Chinese DC constructions and potentially other Chinese multiword sequences. In the initial stage, Chinese instructors should teach DC constructions as coherent lexical chunks to help learners to strengthen the form-function mapping of DC constructions with many examples to demonstrate the usage of them. Next, Chinese instructors could teach the compositionality of DC constructions and introduce the function of the individual DCs. During this stage, Chinese instructors should direct learners’ attention to DCs whose acquisition is likely to be affected by their L1 experience.
Glutamic Acid Residues in HIV-1 p6 Regulate Virus Budding and Membrane Association of Gag
Creators: name: Friedrich, Melanie
name: Setz, Christian
name: Hahn, Friedrich
name: Matthaei, Alina
name: Fraedrich, Kirsten
name: Rauch, Pia
name: Henklein, Petra
name: Traxdorf, Maximilian
name: Fossen, Torgils
name: Schubert, Ulrich
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: HIV-1
subject: Gag p6
subject: l-domains
subject: virus budding
subject: membrane association
subject: ESCRT
subject: Tsg101
subject: ALIX
subject: ubiquitination
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: The HIV-1 Gag p6 protein regulates the final abscission step of nascent virions from the cell membrane by the action of its two late (l-) domains, which recruit Tsg101 and ALIX, components of the ESCRT system. Even though p6 consists of only 52 amino acids, it is encoded by one of the most polymorphic regions of the HIV-1 gag gene and undergoes various posttranslational modifications including sumoylation, ubiquitination, and phosphorylation. In addition, it mediates the incorporation of the HIV-1 accessory protein Vpr into budding virions. Despite its small size, p6 exhibits an unusually high charge density. In this study, we show that mutation of the conserved glutamic acids within p6 increases the membrane association of Pr55 Gag followed by enhanced polyubiquitination and MHC-I antigen presentation of Gag-derived epitopes, possibly due to prolonged exposure to membrane bound E3 ligases. The replication capacity of the total glutamic acid mutant E0A was almost completely impaired, which was accompanied by defective virus release that could not be rescued by ALIX overexpression. Altogether, our data indicate that the glutamic acids within p6 contribute to the late steps of viral replication and may contribute to the interaction of Gag with the plasma membrane.
title: Saxophone music inspired by birds
title: an international perspective
titleType: Subtitle
Creators: name: Zhang, Jichen
Publisher: name: University of Iowa
Year: 2022
Subjects: Birds
Jichen Zhang
Saxophone
public abstract

description: The final product of this project will be a saxophone recording of six pieces and an accompanying paper, for the purpose of enriching saxophone repertoire and providing resources for saxophonists at all levels and other who are interested in saxophone music.The music was written by composers from America, China, and Japan, and all six pieces feature the theme of birds. The recordings demonstrate several different musical languages (jazz, classical and contemporary), diverse instrument configuration (saxophone with percussion, piano, electronics, or solo), and a broad display of the instrument’s capabilities (saxophone techniques such as altissimo, slap-tongues, glissandi, double- tonguing, multi-phonics, etc).
description: The accompanying paper includes the background of each composer and a discussion of the repertoire, liner notes for each piece, a brief conclusion, and appendixes. In the appendixes, it notably includes a list of saxophone repertoire inspired by birds, and a transcript of an interview with composer Wantong Jiang about his newly commissioned music, Capriccio of Swan Goose Theme.
Canadian women and the welfare state in an age of globalization.
Creators: name: Abou-Nassif, Fida.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Canadian Studies.

description: Economic globalization and neo-liberalism have led to the restructuring of the labour market and the dismantling of the welfare state in Canada. The erosion of the Canadian welfare state and the changing labour market have had significant impacts on the lives of Canadian women, men and children. This thesis explores the gendered impacts of globalization and economic restructuring on Canadians in the labour market and the welfare state. We will demonstrate the existence of gender inequalities in the Canadian welfare state and assess the gendered effects of globalization on social citizenship rights in Canada. This thesis will review the Employment Insurance and the Canada Health and Social Transfer programs and will argue that women, in particular, have felt the adverse effects of cutbacks in these welfare state programs and that globalization has thus further intensified the inequalities between women and men. A feminist agenda of initiatives to counter the destructive effects of globalization and economic restructuring is explored.
"A feeling of the responsibility of women for women": The University Women's Club of Ottawa, 1910-1960.
Creators: name: Smith, Laurie Jean.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: History, Canadian.

description: This thesis examines the first fifty years of the University Women's Club of Ottawa, an organization that brought together women graduates of different universities at a time when women were not admitted to post-secondary education in Ottawa. Previous studies of women's voluntary organizations have concentrated on the period prior to 1930. Using the later period of 1910 to 1960, this thesis examines the changing demographics, mandate and related activities of the UWCO during the war, interwar and postwar periods. Drawing almost entirely on internal records, the thesis shows how the club's focus was increasingly externalized, at the same time as it underwent dramatic changes in demography and size. Club members identified first with their status as university graduates, and later in terms of gender. Both world wars served as watersheds in terms of mandate and activities. The thesis provides significant data to allow comparisons with other groups during this period.
The SAURON project - XV. Modes of star formation in early-type galaxies and the evolution of the red sequence
Creators: name: Shapiro, Kristen L.
name: Falcón-Barroso, Jesús
name: van de Ven, Glenn
name: Tim de Zeeuw, P.
name: Sarzi, Marc
name: Bacon, Roland
name: Bolatto, Alberto
name: Cappellari, Michele
name: Croton, Darren
name: Davies, Roger L.
name: Emsellem, Eric
name: Fakhouri, Onsi
name: Krajnović, Davor
name: Kuntschner, Harald
name: McDermid, Richard M.
name: Peletier, Reynier F.
name: van den Bosch, Remco C. E.
name: van der Wolk, Guido
Publisher: name: Swinburne
Year: 2024

description: We combine SAURON integral field data of a representative sample of local early-type, red sequence galaxies with Spitzer/Infrared Array Camera imaging in order to investigate the presence of trace star formation in these systems. With the Spitzer data, we identify galaxies hosting low-level star formation, as traced by polycyclic aromatic hydrocarbon emission, with measured star formation rates that compare well to those estimated from other tracers. This star formation proceeds according to established scaling relations with molecular gas content, in surface density regimes characteristic of disc galaxies and circumnuclear starbursts. We find that star formation in early-type galaxies happens exclusively in fast-rotating systems and occurs in two distinct modes. In the first, star formation is a diffuse process, corresponding to widespread young stellar populations and high molecular gas content. The equal presence of co- and counter-rotating components in these systems strongly implies an external origin for the star-forming gas, and we argue that these star formation events may be the final stages of (mostly minor) mergers that build up the bulges of red sequence lenticulars. In the second mode of star formation, the process is concentrated into well-defined disc or ring morphologies, outside of which the host galaxies exhibit uniformly evolved stellar populations. This implies that these star formation events represent rejuvenations within previously quiescent stellar systems. Evidence for earlier star formation events similar to these in all fast-rotating early-type galaxies suggests that this mode of star formation may be common to all such galaxies, with a duty cycle of roughly 1/10, and likely contributes to the embedded, corotating inner stellar discs ubiquitous in this population.
Trio, a Rho Family GEF, Interacts with the Presynaptic Active Zone Proteins Piccolo and Bassoon
Creators: name: Terry-Lorenzo, Ryan T.
name: Torres, Viviana I.
name: Wagh, Dhananjay
name: Galaz, Jose
name: Swanson, Selene K.
name: Florens, Laurence
name: Washburn, Michael P.
name: Waites, Clarissa L.
name: Gundelfinger, Eckart D.
name: Reimer, Richard J.
name: Garner, Craig C.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Synaptic vesicles (SVs) fuse with the plasma membrane at a precise location called the presynaptic active zone (AZ). This fusion is coordinated by proteins embedded within a cytoskeletal matrix assembled at the AZ (CAZ). In the present study, we have identified a novel binding partner for the CAZ proteins Piccolo and Bassoon. This interacting protein, Trio, is a member of the Dbl family of guanine nucleotide exchange factors (GEFs) known to regulate the dynamic assembly of actin and growth factor dependent axon guidance and synaptic growth. Trio was found to interact with the C-terminal PBH 9/10 domains of Piccolo and Bassoon via its own N-terminal Spectrin repeats, a domain that is also critical for its localization to the CAZ. Moreover, our data suggest that regions within the C-terminus of Trio negatively regulate its interactions with Piccolo/Bassoon. These findings provide a mechanism for the presynaptic targeting of Trio and support a model in which Piccolo and Bassoon play a role in regulating neurotransmission through interactions with proteins, including Trio, that modulate the dynamic assembly of F-actin during cycles of synaptic vesicle exo- and endocytosis.