cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Interaction of proflavine with the RNA polynucleotide polyriboadenylic acid–polyribouridylic acid: photophysical and calorimetric studies
Creators: name: Anirban Basu
name: Gopinatha Suresh Kumar
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Molecular Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine

description: The binding of proflavine, an acriflavine derivative, with the RNA polynucletodide polyadenylic acid–polyuridylic acid is investigated here to understand the structural and thermodynamic basis of the binding process. Such binding data are crucial for designing viable theraperutic agents. Spectroscopic studies clearly suggest a strong binding interaction between proflavine and polyadenylic acid–polyuridylic acid leading to efficient energy transfer between the poly AU base pairs and proflavine. The stoichiometry of proflavine polyadenylic acid–polyuridylic acid binding was independently estimated by continuous variation analysis of Job. An intercalative binding model is envisaged for the binding from hydrodynamic studies. Circular dichroism experiments revealed that the binding induced conformational changes in the RNA, and also led to induction of optical activity in the bound dye molecules. The binding affinity of the complex was deduced to be (6.57 ± 0.75) 105 M−1 at (298.15 ± 0.10) K from isothermal titration calorimetry experiment. Positive entropy and negative enthalpy changes characterized the complexation. The binding was observed to be weaker both at higher temperatures and increased [Na+]. The affinity of binding decreased with increasing [Na+]. When the Gibbs energy was parsed between polyelectrolytic and nonpolyelectropytic components, it surprisingly revealed a higher role for the non-polyelectrolytic forces. These results present new data for developing RNA targeted ligands. Communicated by Ramaswamy H. Sarma
title: Towards a Process Model for Efficient Customer Relationship Management System Selection
Creators: name: Friedrich, Ina
name: Breitner, Michael
Publisher: name: Institut für Wirtschaftsinformatik
Year: 2012
Subjects: subject: 33
subject: 000

description: Changes to the economic and competitive environment require a reorientation of companies’ communication activities, which has implications for the customer relationship management (CRM). Assistance provided by information communication technology (ICT) is an important component of reacting to these potential changes. The failure rate of CRM implementation projects is high when it comes to measuring the impact. It is crucial to evaluate system solutions before making an investment decision. Based on a literature review, the authors developed a CRM evaluation approach to select CRM systems that suit the particular needs of a company. This approach resulted in a CRM system selection (CRMSS) model that covers the whole process of evaluating CRM systems, once a CRM strategy has been defined, and before the implementation phase begins.
description: Multikonferenz Wirtschaftsinformatik 2012 : Tagungsband der MKWI 2012
Additional file 1 of Realistic boundary conditions in SimVascular through inlet catheter modeling
Creators: name: Taebi, Amirtahà
name: Berk, Selin
name: Roncali, Emilie
Publisher: name: figshare
Year: 2021
Subjects: subject: Biophysics
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer

description: Additional file 1. Velocity distribution formulation. The analytical solution used to determine the velocity distribution in the eccentric annulus formed between the vessel wall and catheter.
Hausdorff Convergence and Universal Covers
Creators: name: Sormani, Christina
name: Wei, Guofang
Publisher: name: arXiv
Year: 2000
Subjects: subject: Differential Geometry (math.DG)
subject: General Topology (math.GN)
subject: FOS: Mathematics
subject: 53C20

description: We prove that if $Y$ is the Gromov-Hausdorff limit of a sequence of compact manifolds, $M^n_i$, with a uniform lower bound on Ricci curvature and a uniform upper bound on diameter, then $Y$ has a universal cover. We then show that, for $i$ sufficiently large, the fundamental group of $M_i$ has a surjective homeomorphism onto the group of deck transforms of $Y$. Finally, in the non-collapsed case where the $M_i$ have an additional uniform lower bound on volume, we prove that the kernels of these surjective maps are finite with a uniform bound on their cardinality. A number of theorems are also proven concerning the limits of covering spaces and their deck transforms when the $M_i$ are only assumed to be compact length spaces with a uniform upper bound on diameter.
description: 17 Pages
Type-II Ising superconductivity in two-dimensional materials with strong spin-orbit coupling
Creators: name: Wang, Chong
name: Lian, Biao
name: Guo, Xiaomi
name: Mao, Jiahao
name: Zhang, Zetao
name: Zhang, Ding
name: Gu, Bing-Lin
name: Xu, Yong
name: Duan, Wenhui
Publisher: name: arXiv
Year: 2019
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Recent discovery of Ising superconductivity protected against in-plane magnetic field by spin-orbit coupling (SOC) has stimulated intensive research interests. The effect, however, was only expected to appear in two-dimensional (2D) noncentrosymmetric materials with spin-valley locking. In this work, we proposed a new type of Ising superconductivity in 2D materials with $C_{nz}$ rotational symmetry ($n=3,4,6$). This mechanism, dubbed as type-II Ising superconductivity, is applicable for centrosymmetric materials. Type-II Ising superconductivity relies on the SOC-induced spin-orbital locking characterized by Ising-type Zeeman-like fields displaying opposite signs for opposing orbitals. We found that type-II Ising superconductivity are most prominent around time-reversal invariant momenta and is not sensitive to inversion symmetry breaking. By performing high-throughput first-principles calculations, about one hundred candidate materials were identified. Our work significantly enriches the physics and materials of Ising superconductor, opening new opportunities for fundamental research and practical applications of 2D materials.
Additional file 1 of Hand hygiene behavior among Sri Lankan medical students during COVID-19 pandemic
Creators: name: Liyanage, Guwani
name: Dewasurendra, Madushika
name: Athapathu, Ashan
name: Magodarathne, Lakmini
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1.
title: In-Memory Data Management im Einzelhandel: Einsatzbereiche und Nutzenpotentiale
Creators: name: Piller, Gunther
name: Hagedorn, Jürgen
Publisher: name: Institut für Wirtschaftsinformatik
Year: 2012
Subjects: subject: 33
subject: 000

description: Aktuelle Entwicklungen im Bereich In-Memory Data Management können die Art und Weise, wie betriebliche Anwendungen in Zukunft genutzt werden, signifikant verändern. So ist es möglich, große Volumen von Einzelbelegen direkt in Hauptspeichern vorzuhalten und dort mit hoher Geschwindigkeit zu bearbeiten. Um In-Memory Data Management erfolgreich einzuführen und weiterzuentwickeln, ist es notwendig zu verstehen, welche Arten von Anwendungen von dieser Technologie am meisten profitieren können. Hierzu beschreiben wir mögliche Einsatzbereiche aus dem Einzelhandel. Die Verallgemeinerung von Geschäfts-prozesseigenschaften und Nutzenpotentialen führt zu typischen Anwendungsmustern.
description: Multikonferenz Wirtschaftsinformatik 2012 : Tagungsband der MKWI 2012
Quantum transport in graphene heterostructures
Creators: Young, Andrea Franchini
Publisher: name: Columbia University
Year: 2012
Subjects: Condensed matter

description: The two dimensional charge carriers in mono- and bilayer graphene are described by massless and massive chiral Dirac Hamiltonians, respectively.  This thesis describes low temperature transport experiments designed to probe the consequences of this basic fact.  The first part concerns the effect of the lattice pseudospin, an analog of a relativistic electron spin, on the scattering properties of mono- and bilayer graphene.  We fabricate graphene devices with an extremely narrow local gates, and study ballistic carrier transport through the resulting barrier.  By analyzing the interference of quasiparticles confined to the region beneath the gate, we are able to determine that charge carriers normally incident to the barrier are transmitted perfectly, a solid state analog of the Klein tunneling of relativistic quantum mechanics.  The second part of the work describes the development of hexagonal boron nitride (hBN), an insulating isomorph of graphite, as a substrate and gate dielectric for graphene electronics.  We use the enhanced mobility of electrons in h-BN supported graphene to investigate the effect of electronic interactions. We find interactions drive spontaneous breaking of the emergent SU(4) symmetry of the graphene Landau levels, leading to a variety of quantum Hall isospin ferromagnetic (QHIFM) states, which we study using tilted field magnetotransport.  At yet higher fields, we observe fractional quantum Hall states which show signatures of the unique symmetries and anisotropies of the graphene QHIFM.  The final part of the thesis details a proposal and preliminary experiments to probe isospin ordering in bilayer graphene using capacitance measurements.
Structures and Electromagnetic Properties of New Metal-Ordered Manganites; RBaMn_{2}O_{6} (R = Y and Rare Earth Elements)
Creators: name: Nakajima, T.
name: Kageyama, H.
name: Yoshizawa, H.
name: Ueda, Y.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: New metal-ordered manganites RBaMn_{2}O_{6} have been synthesized and investigated in the structures and electromagnetic properties. RBaMn_{2}O_{6} can be classified into three groups from the structural and electromagnetic properties. The first group (R = La, Pr and Nd) has a metallic ferromagnetic transition, followed by an A-type antiferromagnetic transition in PrBaMn_{2}O_{6}. The second group (R = Sm, Eu and Gd) exhibits a charge-order transition, followed by an antiferromagnetic long range ordering. The third group (R = Tb, Dy and Ho) shows successive three phase transitions, the structural, charge/orbital-order and magnetic transitions, as observed in YBaMn_{2}O_{6}. Comparing to the metal-disordered manganites (R^{3+}_{0.5}A^{2+}_{0.5})MnO_{3}, two remarkable features can be recognized in RBaMn_{2}O_{6}; (1) relatively high charge-order transition temperature and (2) the presence of structural transition above the charge-order temperature in the third group. We propose a possible orbital ordering at the structural transition, that is a possible freezing of the orbital, charge and spin degrees of freedom at the independent temperatures in the third group. These features are closely related to the peculiar structure that the MnO_{2} square-lattice is sandwiched by the rock-salt layers of two kinds, RO and BaO with extremely different lattice-sizes.
description: 5 pages, 4 figures, submitted to J. Phys. Soc. Jpn
Additional file 1 of Analysis of single-cell RNA sequencing data based on autoencoders
Creators: name: Tangherloni, Andrea
name: Ricciuti, Federico
name: Besozzi, Daniela
name: Liò, Pietro
name: Cvejic, Ana
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1. Mathematical formulation of the proposed autoencoders. We provide the mathematical derivation of GMMMD and GMMMDVAE as well as the generalised formulation that we derived by following the notation proposed in [35].
Dieida ledereri Staudinger 1871
Creators: name: Alipanah, Helen
name: Yakovlev, Roman
name: Falsafi, Hossein
name: Witt, Thomas
name: Saldaitis, Aidas
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Cossidae
Dieida
Dieida ledereri

description: Dieida ledereri Staudinger, 1871
(Fig. 22)
 Stygia ledereri Staudinger, 1871a, Cat. Lep. Eur. Faun. 1: 61.
LT: Külek im Taurus [Turkey]. Type material (holotype) in MHUB.
 Dieida persa Strand in Stichel, 1911, syn. n.
 Dieida persa Strand in Stichel, 1911, Zeitschr. Wiss. Ins.-Biol. 7 (5/6): 163.
LT: Prov. Arrak [Iran]. Type material (syntypes) in MHUB, probably lost.
 Material examined. HMIM: Esfahân Prov.: 1 ♀, Semirom, Dolat Gharin, N 31˚32΄22.1˝, E 51˚37΄26.8˝, 2750 m, 13.v.2007, leg. Gilâsiân.
 Diagnosis. In both Dieida persa and D. ledereri the thorax, abdomen and wings are covered with orange scales. Both species are also known only by females. As revealed in this study, no external and morphological differences were observed between the populations from Turkey, Iran and Transcaucasia. The type of D. ledereri was also compared with non-type specimens of D. persa collected in Iran and no differences were found. Therefore, D. persa is being considered as junior synonym of D. ledereri.
 Distribution. Iran, Afghanistan, Syria, Israel, Turkey, Azerbaijan (Staudinger 1879a; Staudinger & Rebel 1901; Schoorl 1990; Yakovlev 2009a, 2010, 2011a; Yakovlev & Pljustch 2014; Yakovlev et al. 2015a).
 Distribution in Iran. Arak (Markazi Province) and Semirom (Esfahan Province) (Yakovlev 2009a, 2011a) (Fig. 35E).
description: Published as part of Alipanah, Helen, Yakovlev, Roman, Falsafi, Hossein, Witt, Thomas & Saldaitis, Aidas, 2021, 5062, pp. 1-100 in Zootaxa 5062 (1) on page 76, DOI: 10.11646/zootaxa.5062.1.1, http://zenodo.org/record/5808035
Comments on the dispersion relation method to vector-vector interaction
Creators: name: Molina, R.
name: Geng, L. S.
name: Oset, E.
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study in detail the method proposed recently to study the vector-vector interaction using the $N/D$ method and dispersion relations, which concludes that, while for $J=0$, one finds bound states, in the case of $J=2$, where the interaction is also attractive and much stronger, no bound state is found. In that work, approximations are done for $N$ and $D$ and a subtracted dispersion relation for $D$ is used, with subtractions made up to a polynomial of second degree in $s-s_\mathrm{th}$, matching the expression to $1-VG$ at threshold. We study this in detail for the $ρ- ρ$ interaction and to see the convergence of the method we make an extra subtraction matching $1-VG$ at threshold up to $(s-s_\mathrm{th})^3$. We show that the method cannot be used to extrapolate the results down to 1270 MeV where the $f_2(1270)$ resonance appears, due to the artificial singularity stemming from the "on shell" factorization of the $ρ$ exchange potential. In addition, we explore the same method but folding this interaction with the mass distribution of the $ρ$, and we show that the singularity disappears and the method allows one to extrapolate to low energies, where both the $(s-s_\mathrm{th})^2$ and $(s-s_\mathrm{th})^3$ expansions lead to a zero of $\mathrm{Re}\,D(s)$, at about the same energy where a realistic approach produces a bound state. Even then, the method generates a large $\mathrm{Im}\,D(s)$ that we discuss is unphysical.
description: 8 pages, 10 figures, 1 table
Sedum ruwenzoriense Baker f.
Creators: name: Zhou, Ya-Dong
name: Mwachala, Geoffrey
name: Hu, Guang-Wan
name: Wang, Qing-Feng
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Saxifragales
Crassulaceae
Sedum
Sedum ruwenzoriense

description: Sedum ruwenzoriense Baker f.  —
Habit: Herb.
Habitat: HZ, AZ, NZ; 2 300–4 500 m. Distribution: IIIa.
 Voucher: Naro Moru Track, 3 934 m, 24 Jul. 2014, SAJIT 002093 (HIB).
References: Young & Peacock (1985), Blundell (1987), Wickens (1987), Bussmann (1993, 1994), Bussmann & Beck (1995a), Agnew (2013).
description: Published as part of Zhou, Ya-Dong, Mwachala, Geoffrey, Hu, Guang-Wan & Wang, Qing-Feng, 2022, Annotated checklist of the vascular plants of Mount Kenya, East Africa, pp. 1-108 in Phytotaxa 546 (1) on page 43, DOI: 10.11646/phytotaxa.546.1.1, http://zenodo.org/record/6550464
title: Handlungsfelder der gestaltungsorientierten Wirtschaftsinformatik im Kontext der Digitalen Fabrik
Creators: name: Hollstein, Philipp
name: Lachenmaier, Jens
name: Lasi, Heiner
name: Kemper, Hans-Georg
Publisher: name: Institut für Wirtschaftsinformatik
Year: 2012
Subjects: subject: 33
subject: 000

description: In Wissenschaft und Praxis beschäftigen sich unterschiedliche Disziplinen mit Methoden, Konzepten und Werkzeugen zur Verbesserung der Leistungsfähigkeit industrieller Unternehmen. Hierfür hat sich der Begriff der Digitalen Fabrik interdisziplinär etabliert, wobei festzustellen ist, dass ein einheitliches und disziplinübergreifendes Verständnis bisher nicht
existiert. In diesem Beitrag werden daher die verschiedenen Definitionen für die Digitale Fabrik aufgezeigt sowie deren Bestandteile strukturiert dargestellt. Darauf aufbauend erfolgt die forschungstheoretisch begründete Zuordnung derjenigen Teilgebiete, die zu den Handlungsfeldern der gestaltungsorientierten Wirtschaftsinformatik gehören. Basierend auf der Erkenntnis, dass die Digitale Fabrik bisher ingenieurswissenschaftlich getrieben ist, werden für die identifizierten Felder Handlungsempfehlungen für die Wirtschaftsinformatik abgeleitet.
description: Multikonferenz Wirtschaftsinformatik 2012 : Tagungsband der MKWI 2012
Region of magnetic dominance near a rotating black hole
Creators: name: Karas, V.
name: Dovciak, M.
Publisher: name: arXiv
Year: 1997
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: This is a brief contribution in which a simplified criterion of the relevance of the test-particle approximation describing motion of material near a magnetized black hole is discussed. Application to processes of the dissipative collimation of astronomical jets (as proposed by de Felice and Curir, 1992) is mentioned.
description: 11 pages, to appear in General Relativity and Gravitation, also available (with additional illustrations) at http://otokar.troja.mff.cuni.cz/user/karas/au_www/karas/papers.htm
Structural exploration of tetrahydroisoquinoline derivatives as HDAC8 inhibitors through multi-QSAR modeling study
Creators: name: Suvankar Banerjee
name: Nilanjan Adhikari
name: Sk. Abdul Amin
name: Jha, Tarun
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 60506 Virology

description: Histone deacetylase 8 (HDAC8) is one of the crucial HDACs responsible for influencing the epigenetic functions of the body. Overexpression of HDAC8 is found to be involved in numerous disease conditions such as tumorigenesis, cell proliferation, cancer, viral infections, neuronal disorders and other epigenetic diseases. Therefore, inhibition of HDAC8 is a primary method to combat these diseases. In this article, a multi-QSAR modeling study on tetrahydroisoquinoline derivatives was conducted to identify important contributions of the structural features of these compounds toward HDAC8 inhibition. All these QSAR modeling techniques were individually validated and justified the observations of each other. The results implied that the tetrahydroisoquinoline moiety may be effective as a cap group than as a linker moiety for HDAC8 inhibition. Different substitutions at the tetrahydroisoquinoline scaffold were also found to be crucial in modulating HDAC8 inhibition. Communicated by Ramaswamy H. Sarma
title: Zum Potential von Event-Driven Architecture für komplexe Unternehmensnetzwerke
Creators: name: Buckel, Thomas
Publisher: name: Institut für Wirtschaftsinformatik
Year: 2012
Subjects: subject: 33
subject: 000

description: Die Komplexität globaler Unternehmensverbände erzeugt eine hohe Heterogenität hinsichtlich der beteiligten Informationssysteme. Damit verbunden nimmt die Anzahl verwobener und den Geschäftsablauf beeinflussender Ereignisse erheblich zu, die von zahlreichen Quellen produziert werden. Das in dieser Arbeit vorgestellte Einsatzszenario einer Serviceorientierten Architektur (SOA) in Verbindung mit der Technologie der Event-Driven Architecture (EDA) bietet großes Potential, Struktur in die Fülle an auftretenden Ereignissen zu bringen, diese effektiv zu verarbeiten und gewinnbringend in den Geschäfts-ablauf zu integrieren. Intelligent verbunden und die Vorteile dieser Informationsarchitektur ausnutzend, kann ein derartiges Konzept Wettbewerbsvorteile für die gesamte, globale Lieferkette und damit einhergehend für jedes einzelne beteiligte Unternehmen schaffen.
description: Multikonferenz Wirtschaftsinformatik 2012 : Tagungsband der MKWI 2012
Provincial seed bank for native plant species feasibility survey
Creators: name: White, Taylor
name: Carson, Allan W.
name: Keefer, Michael E.
Publisher: name: The University of British Columbia
Year: 2017

description: In British Columbia, the use of native plants in revegetating disturbed land is becoming standard practice. As local communities become more aware and involved in resource development, the demand for utilizing native plants for reclamation and restoration activities continues to grow. Various resource sectors in BC have responded by increasing their utilization of native plant species. However, uncertainty in relation to native seed availability, including factors such as timing, volume and species, still pose significant challenges to industries working to incorporate native species in their revegetation plans. To explore these challenges, Keefer Ecological Services Ltd., DWB Consulting Services Ltd. and the BC Conservation Foundation are conducting a feasibility study to investigate the viability of developing a provincial seed bank for non-commercial native seed. The initial phase of this study was completed during the spring/summer of 2016 and included a stakeholder survey and review of seed bank models from around the world. The goal of the survey was to enlist a variety of stakeholders to share their opinions on a potential native seed bank facility in BC. Our survey focused on three main topics: Opportunities & Challenges, Functions & Practicality, and Governance & Structure. The paper reports on the findings of the initial phase of the study.
Quasi-local energy and isometric embedding
Creators: Gimre, Karsten Trevor
Publisher: name: Columbia University
Year: 2016
Subjects: subject: Isometrics (Mathematics)
subject: Generalized spaces
subject: Mathematics
subject: FOS: Mathematics

description: In this thesis, we consider the recent definition of gravitational energy at the quasi-local level provided by Mu-Tao Wang and Shing-Tung Yau. Their definition poses a variational question predicated on isometric embedding of Riemannian surfaces into the Minkowski space; as such, there is a naturally associated Euler-Lagrange equation, which is a fourth-order system of partial differential equations for the embedding functions. We prove a perturbation result for solutions of this Euler-Lagrange equation.
Reduction of Presymplectic Manifolds with Symmetry
Creators: name: quez, A. Echeverrí a-Enrí
name: Muñoz-Lecanda, M. C.
name: Román-Roy, N.
Publisher: name: arXiv
Year: 1999
Subjects: subject: Mathematical Physics (math-ph)
subject: Classical Physics (physics.class-ph)
subject: FOS: Physical sciences

description: Actions of Lie groups on presymplectic manifolds are analyzed, introducing the suitable comomentum and momentum maps. The subsequent theory of reduction of presymplectic dynamical systems with symmetry is studied. In this way, we give a method of reduction which enables us to remove gauge symmetries as well as non-gauge ``rigid'' symmetries at once. This method is compared with other step-by-step reduction procedures. As particular examples in this framework, we discuss the reduction of time-dependent dynamical systems with symmetry, the reduction of a mechanical model of field theories with gauge and non-gauge symmetries, and the gauge reduction of the system made of a conformal particle.
description: 36 pages. LaTeX file. To be published in Reviews in Mathematical Physics
Comparative omics analyses of hepatotoxicity induced by oral azole drugs in mice liver and primary hepatocytes
Creators: name: Se-Myo Park
name: Seung-Jun Kang
name: Choi, Mi-Sun
name: Soojin Kim
name: Seokjoo Yoon
name: Oh, Jung-Hwa
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: Ketoconazole (KTZ) and itraconazole (ITZ) are antifungal agents that have a broad spectrum of activity against fungal pathogens. However, the therapeutic indications of many antifungal drugs, including those of the azole group, are restricted due to possible hepatotoxicity. We performed toxicogenomic analyses using in vivo and in vitro models to investigate the molecular mechanisms underlying the hepatotoxicity of two azole antifungal drugs. C57BL/6 male mice were treated daily with KTZ or ITZ, sacrificed at day 1 or 7, and the serum biochemistry and histopathology results showed that the KTZ-treated mice exhibited hepatotoxicity. Primary hepatocytes from C57BL/6 mice also exposed to KTZ or ITZ, and the cytotoxic effects of KTZ and ITZ were evaluated; KTZ exerted a greater cytotoxic effect than ITZ. The gene expression profiles in the livers of the 7-day-treated group and primary hepatocytes of the 24-h-treated group for both KTZ and ITZ were comparatively analyzed. Differentially expressed genes were selected based on fold-changes and statistical significance, and the biological functions were analyzed using Ingenuity Pathways Analysis. The results revealed that genes related to cholesterol synthesis were overexpressed in the liver in the KTZ-treated group, whereas expression of those related to acute phase injury was significantly altered in the ITZ-treated group. Causal gene analyses suggested that sterol regulatory element-binding transcription factors are key regulators that activate the transcription of target genes associated with the hepatotoxicity induced by oral KTZ. These findings enhance our understanding of the molecular mechanisms underlying the hepatotoxicity of azole drugs.
Umbilicus botryoides A. Rich.
Creators: name: Zhou, Ya-Dong
name: Mwachala, Geoffrey
name: Hu, Guang-Wan
name: Wang, Qing-Feng
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Saxifragales
Crassulaceae
Umbilicus
Umbilicus botryoides

description: Umbilicus botryoides Hochst. ex A.Rich.  —
Habit: Herb.
Habitat: BZ, UMF, HZ; 2 200–3 600 m. Distribution: II.
 Voucher: Naro Moru Track, Alt. 3 194 m, 13 Jun. 2010, Kirika et al. KMK81 (EA).
References: Bussmann (1993, 1994), Agnew (2013).
description: Published as part of Zhou, Ya-Dong, Mwachala, Geoffrey, Hu, Guang-Wan & Wang, Qing-Feng, 2022, Annotated checklist of the vascular plants of Mount Kenya, East Africa, pp. 1-108 in Phytotaxa 546 (1) on page 43, DOI: 10.11646/phytotaxa.546.1.1, http://zenodo.org/record/6550464
title: Manufacturing Execution Systeme – die neue Generation von Produktionsplanungs und -steuerungs-Systemen?
Creators: name: Olbrich, Sebastian
name: Louis, Philipp
Publisher: name: Institut für Wirtschaftsinformatik
Year: 2012
Subjects: subject: 33
subject: 000

description: Manufacturing Execution Systeme (MES) sind eine relativ neue Klasse von Anwendungssystemen, die immer mehr in den Mittelpunkt bei der Betrachtung der IT-Unterstützung für die Industrie rücken. Dem Integrationsgedanken der Wirtschaftsinformatik folgend, steht bei diesen Systemen die integrative Unterstützung sämtlicher Produktionsprozesse - also auch der Produktionsplanung und -steuerung - im Fokus. Hierbei stellt sich unmittelbar die Frage, ob diese neuen Systeme traditionelle Produktionsplanungsu nd -steuerungs-Systeme (PPS-Systeme) ersetzen oder sie ergänzen sollten. Diese Frage soll im vorliegenden Artikel dadurch bearbeitet werden, indem die Gemeinsamkeiten und Unterschiede zwischen PPS-Systemen und MES expliziert und Integrationsempfehlungen gegeben werden.
description: Multikonferenz Wirtschaftsinformatik 2012 : Tagungsband der MKWI 2012
Estimates of Fast Radio Burst Dispersion Measures from Cosmological Simulations
Creators: name: Pol, N.
name: Lam, M. T.
name: McLaughlin, M. A.
name: Lazio, T. J. W.
name: Cordes, J. M.
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We calculate the dispersion measure (DM) contributed by the intergalactic medium (IGM) to the total measured DM for fast radio bursts (FRBs). We use the MareNostrum Instituto de Ciencias del Espacio (MICE) Onion Universe simulation (Fosalba et al. 2008) to track the evolution of the dark matter particle density over a large range of redshifts. We convert this dark matter particle number density to the corresponding free electron density and then integrate it to find the DM as a function of redshift. This approach yields an intergalactic DM of $\rm DM_{\rm IGM}(z = 1) = 800^{+7000}_{-170}$ pc cm$^{-3}$, with the large errors representative of the structure in the IGM. We place limits on the redshifts of the current population of observed FRBs. We also use our results to estimate the host galaxy contribution to the DM for the first repeater, FRB 121102, and show that the most probable host galaxy DM contribution, $\rm DM_{\rm host} \approx 310$ pc cm$^{-3}$, is consistent with the estimate made using the Balmer emission lines in the spectrum of the host galaxy, $\rm DM_{\rm Balmer} = 324$ pc cm$^{-3}$ (Tendulkar et al. 2017). We also compare our predictions for the host galaxy contribution to the DM for the observations of FRB 180924 (Bannister et al. 2019) and FRB 190523 (Ravi et al. 2019), both of which have been localized to a host galaxy.
description: Resubmitted to ApJ following second round of referee comments. Expanded sub-section comparing our results to those from other works (Sec. 3.3)
title: Defizite und Potentiale im Bereich der Usability betriebswirtschaftlicher Anwendungen in Kleinst-, Klein- und mittelständischen Unternehmen am Beispiel des Freistaats Sachsen
Creators: name: Lambeck, Christian
name: Leyh, Christian
Publisher: name: Institut für Wirtschaftsinformatik
Year: 2012
Subjects: subject: 33
subject: 000

description: Die Mehrheit betriebswirtschaftlicher Anwendungen nutzt zur Darstellung formularbasierte Dialoge, Menüs und tabellarische Auflistungen. Das damit verbundene Defizit äußert sich in der vollumfänglichen Präsentation des Informationsraums (z.B. in Form einer Tabelle mit mehreren tausend Datensätzen). Die Möglichkeiten, den Detailgrad sowie die Darstellungs-form der Informationen zu bestimmen, sind nur sehr eingeschränkt vorhanden. Zudem muss der Anwender über Kenntnisse der Dialogstruktur verfügen, um mit den Daten sowie den Operationen auf ihnen umgehen zu können. Die vorliegende Studie soll die Potentiale und Defizite am Beispiel des Freistaats Sachsen genauer untersuchen. Sie soll zudem Aufschluss darüber geben, welche Bedürfnisse bezüglich der Benutzeroberfläche vorhanden sind und welchen Schwerpunkten sich anschließende Forschungsfragen widmen sollten.
description: Multikonferenz Wirtschaftsinformatik 2012 : Tagungsband der MKWI 2012
Class and Urban Public Space Consumption: A Typology in Isfahan, Iran
Creators: name: Rabiei, Kamran
name: Golrokh, Shamin
name: Bahrami, Zahra
Publisher: name: Faculty of Fine and Applied Arts Chulalongkorn University
Year: 2021
Subjects: Social Class
Public Space
Consumption
Bourdieu
Isfahan
Iran

description: Journal of Urban Culture Research, 22, -, 3-19
A hypothesis concerning "quantal" Hilbert space criterion of chaos in nonlinear dynamical systems
Creators: name: Kowalski, Krzysztof
Publisher: name: arXiv
Year: 1998
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Based on the Hilbert space approach to the theory of nonlinear dynamical systems developed by the author a hypothesis is formulated concerning the "quantal" criterion for classical ordinary differential systems to exhibit chaotic behaviour.
description: 10 pages LaTeX
When Sets Are Not Sum-dominant
Creators: name: Chu, Hung Viet
Publisher: name: arXiv
Year: 2019
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11P99

description: Given a set $A$ of nonnegative integers, define the sum set $$A+A = \{a_i+a_j\mid a_i,a_j\in A\}$$ and the difference set $$A-A = \{a_i-a_j\mid a_i,a_j\in A\}.$$ The set $A$ is said to be sum-dominant if $|A+A|>|A-A|$. In answering a question by Nathanson, Hegarty used a clever algorithm to find that the smallest cardinality of a sum-dominant set is $8$. Since then, Nathanson has been asking for a human-understandable proof of the result. We offer a computer-free proof that a set of cardinality less than $6$ is not sum-dominant. Furthermore, we prove that the introduction of at most two numbers into a set of numbers in an arithmetic progression does not give a sum-dominant set. This theorem eases several of our proofs and may shed light on future work exploring why a set of cardinality $6$ is not sum-dominant. Finally, we prove that if a set contains a certain number of integers from a specific sequence, then adding a few arbitrary numbers into the set does not give a sum-dominant set.
description: 16 pages, published in J. Integer Seq
Chinese Paradox: Where are Chinese Monuments?
Creators: name: Castelli, Alberto
Publisher: name: Faculty of Fine and Applied Arts Chulalongkorn University
Year: 2021
Subjects: subject: Architecture
subject: FOS: Civil engineering
subject: Buddhism
subject: China
subject: Daoism
subject: Iconoclasm
subject: Monuments

description: Journal of Urban Culture Research, 22, -, 20-36
Timing information at HL-LHC: Complete determination of masses of Dark Matter and Long lived particle
Creators: name: Flowers, Zachary
name: Kang, Dong Woo
name: Meier, Quinn
name: Park, Seong Chan
name: Rogan, Christopher
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: A long standing problem in kinematics at the hadron colliders is to determine the mass of invisible particles. This issue is particularly important for the signals of dark matter, which becomes one of the prominent targets of future collider experiments. In this paper, we show that the additional information from the precise timing measurement, which will be available at the planned high-liminosity run of the LHC (HL-LHC), will shade new light on the kinematics study. As a concrete example, we focus on the signal of the pair produced long-lived particles ($LLP_{1,2}$), respectively leaving displaced vertex with visible ($V_{1,2}$) and invisible ($I_{1,2}$) final state, $pp \to LLP_1+LLP_2 \to (V_1+I_1)+(V_2+I_2)$. We explicitly show that this system is completely solvable with timing information.
description: 14 pages, 5 figures
title: Dynamische Neuplanung der Touren von Express Trucks unter Einbeziehung einer FCD-basierten Verkehrslage
Creators: name: Ebendt, Rüdiger
name: Sohr, Alexander
name: Touko-Tcheumadjeu, Louis
name: Wagner, Peter
Publisher: name: Institut für Wirtschaftsinformatik
Year: 2012
Subjects: subject: 33
subject: 000

description: In den letzten zehn Jahren wurden im Deutschen Zentrum für Luft- und Raumfahrt (DLR) eine Reihe von prototypischen ITS-Diensten entwickelt, die auf „Floating Car Data“ (FCD) basieren. Eine Schlüsselanwendung ist dabei ein FCD-basiertes System zur Verkehrslenkung und Routenüberwachung. Dieses System wurde im BMWi-Förderprojekt „SmartTruck“ erweitert. Ein wichtiges Ziel dieses Projektes war die Verwendung von historischen und aktuellen Verkehrsinformationen für die energiesparende, optimierte offline-Planung und anschließende dynamische online-Neuplanung der Stoppreihenfolgen von Touren der DHL Express Trucks in Berlin. Diese Arbeit diskutiert die Architektur und eine wesentliche Neuerung des hierbei verwendeten FCD-Systems, eine Datenbank mit Performanzprofilen von Methoden zur Bearbeitung von Routenanfragen.
description: Multikonferenz Wirtschaftsinformatik 2012 : Tagungsband der MKWI 2012
Possible d+id scenario in La_{2-x}Sr_{x}CuO_4 by point-contact measurements
Creators: name: Daghero, D.
name: Gonnelli, R. S.
name: Ummarino, G. A.
name: Stepanov, V. A.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We analyze the results of point-contact measurements in La_{2-x}Sr_{x}CuO_{4} (LSCO) previously reported as a clear evidence of the separation between gap and pseudogap in this copper oxide. Here we show that, in addition to this, the conductance curves of our point-contact junctions -- showing clear Andreev reflection features -- can be interpreted as supporting a nodeless d_{x^2-y^2}+id_{xy}-wave symmetry of the gap in LSCO. The results of our analysis, in particular the doping dependence of the subdominant d_{xy} gap component, are discussed and compared to the predictions of different theoretical models.
description: 6 pages, 4 eps figures, presented at SATT11 Conference (Vietri sul Mare, March 2002). To appear in Int. J. Mod. Phys
Technology Singularity in Culture: The Urgency of the Problem in the COVID-19 Pandemic
Creators: name: Sovhyra, Tetiana
Publisher: name: Faculty of Fine and Applied Arts Chulalongkorn University
Year: 2021
Subjects: Culture
AI Art
Global Pandemic
Artificial Intelligence
Algorithmic Analysis
Technological Singularity

description: Journal of Urban Culture Research, 22, -, 37-49
Mass formulae for a class of nonrotating black holes
Creators: name: Heusler, Markus
Publisher: name: arXiv
Year: 1997
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In the presence of a Killing symmetry, various self-gravitating field theories with massless scalars (moduli) and vector fields reduce to sigma-models, effectively coupled to 3-dimensional gravity. We argue that this particular structure of the Einstein-matter equations gives rise to quadratic relations between the asymptotic flux integrals and the area and surface gravity (Hawking temperature) of the horizon. The method is first illustrated for the Einstein-Maxwell system. A derivation of the quadratic formula is then also presented for the Einstein-Maxwell-axion-dilaton model, which is relevant to the bosonic sector of heterotic string theory.
description: 18 pages, revtex, no figures
Additional file 5 of AXL kinase-mediated astrocytic phagocytosis modulates outcomes of traumatic brain injury
Creators: name: Zhou, Hang
name: Hu, Libin
name: Li, Jianru
name: Ruan, Wu
name: Cao, Yang
name: Zhuang, Jianfeng
name: Xu, Hangzhe
name: Peng, Yucong
name: Zhang, Zhongyuan
name: Xu, Chaoran
name: Yu, Qian
name: Li, Yin
name: Dou, Zhangqi
name: Hu, Junwen
name: Wu, Xinyan
name: Yu, Xiaobo
name: Gu, Chi
name: Cao, Shenglong
name: Yan, Feng
name: Chen, Gao
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 5:. Supplementary Information: text summary
Remote blind state preparation with weak coherent pulses in the field
Creators: name: Jiang, Yang-Fan
name: Wei, Kejin
name: Huang, Liang
name: Xu, Ke
name: Sun, Qi-Chao
name: Zhang, Yu-Zhe
name: Zhang, Weijun
name: Li, Hao
name: You, Lixing
name: Wang, Zhen
name: Lo, Hoi-Kwong
name: Xu, Feihu
name: Zhang, Qiang
name: Pan, Jian-Wei
Publisher: name: arXiv
Year: 2019
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum computing has seen tremendous progress in the past years. Due to the implementation complexity and cost, the future path of quantum computation is strongly believed to delegate computational tasks to powerful quantum servers on cloud. Universal blind quantum computing (UBQC) provides the protocol for the secure delegation of arbitrary quantum computations, and it has received significant attention. However, a great challenge in UBQC is how to transmit quantum state over long distance securely and reliably. Here, we solve this challenge by proposing and demonstrating a resource-efficient remote blind qubit preparation (RBQP) protocol with weak coherent pulses for the client to produce, using a compact and low-cost laser. We demonstrate the protocol in field, experimentally verifying the protocol over 100-km fiber. Our experiment uses a quantum teleportation setup in telecom wavelength and generates $1000$ secure qubits with an average fidelity of $(86.9\pm1.5)\%$, which exceeds the quantum no-cloning fidelity of equatorial qubit states. The results prove the feasibility of UBQC over long distances, and thus serving as a key milestone towards secure cloud quantum computing.
description: 11 pages, 9 figures
Porous silicon-based electrochemical biosensors
Creators: name: KEYING GUO
Publisher: name: Monash University
Year: 2020
Subjects: subject: 100402 Medical Biotechnology Diagnostics (incl. Biosensors)
subject: FOS: Medical biotechnology
subject: 30604 Electrochemistry
subject: FOS: Chemical sciences
subject: Biochemistry

description: Electrochemical biosensors have emerged as very powerful analytical tools in many challenging areas including water and food quality control, and biomedical diagnostics. Porous silicon (pSi) has many desired properties to be used as sensing platform (e.g. extensively tunable structure, versatile surface chemistry and large surface area). However, unavoidable growth of the insulating layer SiO2 at the surface hinders pSi to be used as electrochemical transducer. Therefore, the potential to use carbon-stabilized pSi as electrochemical transducers to design simple, cost-effective, high sensitive and label-free electrochemical biosensors was explored. The designed pSi-based electrochemical biosensors were successfully used for detection of analytes of interest for water quality control and medical diagnostics.
Impacts of the intrinsic charm content of the proton on the $Ξ_{cc}$ hadroproduction at a fixed target experiment at the LHC
Creators: name: Chen, Gu
name: Wu, Xing-Gang
name: Xu, Shuai
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In the present paper, we present detailed discussions on the hadronic production of $Ξ_{cc}$ at a fixed target experiment at the LHC (After@LHC). The charm quarks in hadron could be either extrinsic or intrinsic. By using the BHPS model as the intrinsic charm distribution function in proton, we observe that even if by setting the proportion of finding the intrinsic charm in a proton as $A_{\rm in}=1\%$, total cross sections for the $g+c$ and $c+c$ production mechanisms shall be enhanced by nearly two times. Thus the number of $Ξ_{cc}$ events to be generated at the After@LHC can be greatly enhanced. Since the total cross sections and differential distributions for the $Ξ_{cc}$ production at the After@LHC are sensitive to the value of $A_{\rm in}$, the After@LHC could be a good platform for testing the idea of intrinsic charm.
description: 13 pages, 17 figures
Transformation of the Relationship Between Neighborhood & Sociality Space and Land Use in Tripoli Lebanon
Creators: name: Kassab, Naho
Publisher: name: Faculty of Fine and Applied Arts Chulalongkorn University
Year: 2021
Subjects: Urban fabric
Culture
Space
Social Life
Land Use
Tripoli
Lebanon

description: Journal of Urban Culture Research, 22, -, 50-64
A variational principle for domino tilings
Creators: name: Cohn, Henry
name: Kenyon, Richard
name: Propp, James
Publisher: name: arXiv
Year: 2000
Subjects: subject: Combinatorics (math.CO)
subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 82B20, 82B23, 82B30

description: We formulate and prove a variational principle (in the sense of thermodynamics) for random domino tilings, or equivalently for the dimer model on a square grid. This principle states that a typical tiling of an arbitrary finite region can be described by a function that maximizes an entropy integral. We associate an entropy to every sort of local behavior domino tilings can exhibit, and prove that almost all tilings lie within epsilon (for an appropriate metric) of the unique entropy-maximizing solution. This gives a solution to the dimer problem with fully general boundary conditions, thereby resolving an issue first raised by Kasteleyn. Our methods also apply to dimer models on other grids and their associated tiling models, such as tilings of the plane by three orientations of unit lozenges.
description: 49 pages, 7 figures. This revision of the published paper corrects a typo (reversal of s and t, and an incorrect sign) that propagated through several equations. See the first page for details. All changes from the published version are also marked with "UPDATE" in the TeX source. None of the logic needed to be changed
Assessing and optimizing microbial processes impacting mine reclamation
Creators: name: Friesen, Vanessa
name: Haakensen, Monique
Publisher: name: The University of British Columbia
Year: 2017

description: Microbes influence a wide range of processes, acting as catalysts to accelerate reactions or enable them to occur in a wider range of conditions. In the context of mine reclamation, many aspects are impacted by microbes and understanding their role is critical to making informed decisions, optimizing processes, and improving reclamation success. Examples of microbes affecting mine reclamation processes will be presented, including: passive- and semi-passive water treatment (including metals, metalloids, ammonia, nitrate, acid-rock drainage, heap leach detoxification), soil bioremediation, and revegetation. An overview of the tools currently being used at mines for microbial community profiling will be discussed, spanning from traditional growth-based techniques, through to modern day standardized genetic community profiling based on DNA-sequencing. This information will be provided in the context of how they have been used to guide and optimize mine reclamation strategies.