cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Averell Harriman's Mission to Moscow
Creators: Pechatnov, V. O.
Publisher: name: Columbia University
Year: 2003
Subjects: subject: International relations
subject: Political science
subject: FOS: Political science
subject: Diplomacy
subject: World War (1939-1945)

description: Averell Harriman holds a special place in the ranks of important American diplomats of the twentieth century who represented the U.S. in Moscow, not only thanks to his personal qualities, but also because the years of his ambassadorship coincide with what was perhaps the most critical period in Soviet-American relations: the conception of a military and political alliance that came into being in the monumental fight against a deadly enemy. Harriman, Roosevelt’s trusted emissary, highly esteemed by both the Kremlin and Whitehall, became an eyewitness and active participant in political decisions that were to affect the fate of millions of people. Although Harriman’s Moscow mission has been thoroughly chronicled by the ambassador himself, and has also been studied by several Russian and American historians, the release of new archival documents in Russia and the U.S. occasions a new reading of many pages from this historic diplomatic mission.
Table S4 from Rapid functional and evolutionary changes follow gene duplication in yeast
Creators: name: Naseeb, Samina
name: Ames, Ryan M.
name: Delneri, Daniela
name: Lovell, Simon C.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences

description: Duplication of genes or genomes provides the raw material for evolutionary innovation. After duplication a gene may be lost, recombine with another gene, have its function modified, or be retained in an unaltered state. The fate of duplication is usually studied by comparing extant genomes and reconstructing the most likely ancestral states. Valuable as this approach is, it may miss the most rapid evolutionary events. Here, we engineered strains of Saccharomyces cerevisiae carrying tandem and non-tandem duplications of the singleton gene IFA38 to monitor (i) the fate of the duplicates in different conditions, including timescale and asymmetry of gene loss and (ii) the changes in fitness and transcriptome of the strains immediately after duplication and after experimental evolution. We found that the duplication brings widespread transcriptional changes but a fitness advantage is only present in fermentable media. In respiratory conditions, the yeast strains consistently lose the non-tandem IFA38 gene copy in a surprisingly short time, within only few generations. This gene loss appears to be asymmetric and dependent on genome location since the original IFA38 copy and the tandem duplicate are retained. Overall, this work shows for the first time that gene loss can be extremely rapid and context dependent.
McKnight_Discussion_ESM from Quantifying and reducing the cost of tagging: Combining computational fluid dynamics and diving experiments to reduce impact from animal-borne tags
Creators: name: McKnight, J.Chris
name: Pass, Chris
name: Thompson, Dave
name: Balfour, Steve
name: Brasseur, Sophie
name: Embling, Clare
name: Hastie, Gordon
name: Milne, Ryan
name: Kyte, Adam
name: Moss, Simon
name: Pemberton, Richard
name: Russell, Debbie
Publisher: name: The Royal Society
Year: 2024
Subjects: classificationCode: 310901
subject: Animal behaviour

description: Supplementary Discussion with Figures
McKnight_Tables_ESM from Quantifying and reducing the cost of tagging: Combining computational fluid dynamics and diving experiments to reduce impact from animal-borne tags
Creators: name: McKnight, J.Chris
name: Pass, Chris
name: Thompson, Dave
name: Balfour, Steve
name: Brasseur, Sophie
name: Embling, Clare
name: Hastie, Gordon
name: Milne, Ryan
name: Kyte, Adam
name: Moss, Simon
name: Pemberton, Richard
name: Russell, Debbie
Publisher: name: The Royal Society
Year: 2024
Subjects: classificationCode: 310901
subject: Animal behaviour

description: Supplementary Tables
Beyond Resentment
Creators: Riabchuk, Mykola
Publisher: name: Columbia University
Year: 2011
Subjects: International relations
Self-determination, National

description: Review of Vasyl Kuchabsky, Western Ukraine in Conflict with Poland and Bolshevism, 1918-1923. Translated from the German by Gus Fagan. Edmomton and Toronto: Canadian Institute of Ukrainian Studies Press, 2009. 361 pp. + 6 maps.
Supplementary Material from Quantifying and reducing the cost of tagging: Combining computational fluid dynamics and diving experiments to reduce impact from animal-borne tags
Creators: name: McKnight, J.Chris
name: Pass, Chris
name: Thompson, Dave
name: Balfour, Steve
name: Brasseur, Sophie
name: Embling, Clare
name: Hastie, Gordon
name: Milne, Ryan
name: Kyte, Adam
name: Moss, Simon
name: Pemberton, Richard
name: Russell, Debbie
Publisher: name: The Royal Society
Year: 2024
Subjects: classificationCode: 310901
subject: Animal behaviour

description: Tables S5 and S6
Additional file 10 of Ogt-mediated O-GlcNAcylation inhibits astrocytes activation through modulating NF-κB signaling pathway
Creators: name: Dong, Xiaoxue
name: Shu, Liqi
name: Zhang, Jinyu
name: Yang, Xu
name: Cheng, Xuejun
name: Zhao, Xingsen
name: Qu, Wenzheng
name: Zhu, Qiang
name: Shou, Yikai
name: Peng, Guoping
name: Sun, Binggui
name: Yi, Wen
name: Shu, Qiang
name: Li, Xuekun
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 10: Figure S10. The original images of all western blot assays.
Briefing Note: Aligning International Investment Agreements with the Sustainable Development Goals
Creators: Johnson, Lise
Sachs, Lisa E.
Lobel, Nathan Wiener
Publisher: name: Columbia University
Year: 2020
Subjects: Investments, Foreign
Investments, Foreign (International law)
Sustainable development

description: International investment agreements (“IIAs”) provide enforceable protections to foreign investors based on the premise that enforceable investor protections will stimulate greater foreign investment flows, which, in turn, are assumed to promote development. However, as understandings of both the effectiveness of these agreements as well as the effects of investment and investment governance on sustainable development have evolved, it is not clear that IIAs, as currently designed, are fit for their purpose of promoting development. Worse: they may be undermining efforts to achieve the Sustainable Development Goals. Change is, therefore, essential. In this note, we summarize our proposal that IIAs should be designed and evaluated with respect to their ability to: • Encourage and channel investments that contribute to sustainable development, and do not support harm-causing investments; • Foster, and not constrain, responsible, SDG-advancing governance at the national level; and • Promote international cooperation to overcome transnational and collective action challenges related to the governance of international investment.
Additional file 1 of USP40 promotes hepatocellular carcinoma cell proliferation, migration and stemness by deubiquitinating and stabilizing Claudin1
Creators: name: Wu, Qingsong
name: Qiu, Yuanyuan
name: Guo, Jinhui
name: Yuan, Zibo
name: Yang, Yingnan
name: Zhu, Qingwei
name: Zhang, Zhe
name: Guo, Junwei
name: Wu, Yanfang
name: Zhang, Junyu
name: Huang, Dongsheng
name: Tu, Kangsheng
name: Hu, Xiaoge
Publisher: name: figshare
Year: 2024
Subjects: Biochemistry
Medicine
Molecular Biology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Virology

description: Additional file 1. Supplementary Tables.
Carrying on the Fight
Creators: Mariano, Aisah Czarianne
Publisher: name: Columbia University
Year: 2019
Subjects: Human rights
Indigenous peoples
Indigenous youth
Indigenous peoples--Politics and government

description: I have been a part of the Indigenous Peoples’ struggle since I was studying in college. Little did I know of my culture as I grew up in the city, yet the work of urban-based Indigenous Peoples’ organizations has led me to realize the different issues faced by Indigenous Peoples. It started with a question of “why” and “how” Indigenous youth can better the situation of Indigenous Peoples and become present and future leaders. Now, as a part of the Asia Young Indigenous Peoples Network (AYIPN), it has come as a realization to me that Indigenous youth can and will change the path to a better and more sustainable future for Indigenous Peoples worldwide.
Table S2 from Rapid functional and evolutionary changes follow gene duplication in yeast
Creators: name: Naseeb, Samina
name: Ames, Ryan M.
name: Delneri, Daniela
name: Lovell, Simon C.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences

description: Duplication of genes or genomes provides the raw material for evolutionary innovation. After duplication a gene may be lost, recombine with another gene, have its function modified, or be retained in an unaltered state. The fate of duplication is usually studied by comparing extant genomes and reconstructing the most likely ancestral states. Valuable as this approach is, it may miss the most rapid evolutionary events. Here, we engineered strains of Saccharomyces cerevisiae carrying tandem and non-tandem duplications of the singleton gene IFA38 to monitor (i) the fate of the duplicates in different conditions, including timescale and asymmetry of gene loss and (ii) the changes in fitness and transcriptome of the strains immediately after duplication and after experimental evolution. We found that the duplication brings widespread transcriptional changes but a fitness advantage is only present in fermentable media. In respiratory conditions, the yeast strains consistently lose the non-tandem IFA38 gene copy in a surprisingly short time, within only few generations. This gene loss appears to be asymmetric and dependent on genome location since the original IFA38 copy and the tandem duplicate are retained. Overall, this work shows for the first time that gene loss can be extremely rapid and context dependent.
Case Studies in Asia Regarding Indigenous Women, Development, and Access to Justice
Creators: Asian Indigenous People Pact
Publisher: name: Columbia University
Year: 2014
Subjects: subject: Indigenous peoples--Civil rights
subject: Economic development
subject: Indigenous peoples--Government policy
subject: Human rights
subject: Indigenous women
subject: Law
subject: FOS: Law
subject: Women's studies
subject: Asians

description: Case studies were conducted in the five countries—Cambodia, Lao PDR, Malaysia, Philippines and Thailand—on issues that Indigenous women in Asia are facing with respect to development projects: access to justice; and the promotion, protection and respect of their rights both as women and as Indigenous Peoples. Development projects in this context refer to both State and corporate projects that are intended to support national development, i.e., economic growth or national priorities like the establishment of protected areas. These projects include mining, economic land concessions, national parks and plantations. The case studies look at the national legal and policy framework on women’s rights and Indigenous Peoples’ rights as it relates to the situation of Indigenous women in the respective countries. A community profile is provided for each case to establish the context. Information is shared on the development project and the violations of the rights of Indigenous women that the project causes. Analysis is also provided on obstacles that Indigenous women face for accessing justice related to the development project. In the conclusion, Indigenous women propose recommendations to address these obstacles to access to justice.
On the Influence of Twitter Trolls during the 2016 US Presidential Election
Creators: name: Salamanos, Nikos
name: Jensen, Michael J.
name: Xinlei He
name: Chen, Yang
name: Sirivianos, Michael
Publisher: name: Zenodo
Year: 2019

description: It is a widely accepted fact that state-sponsored Twitter accounts operated during the 2016 US presidential election spreading millions of tweets with misinformation and inflammatory political content. Whether these social media campaigns of the so-called "troll" accounts were able to manipulate public opinion is still in question. Here we aim to quantify the influence of troll accounts and the impact they had on Twitter by analyzing 152.5 million tweets from 9.9 million users, including 822 troll accounts. The data collected during the US election campaign, contain original troll tweets before they were deleted by Twitter. From these data, we constructed a very large interaction graph; a directed graph of 9.3 million nodes and 169.9 million edges. Recently, Twitter released datasets on the misinformation campaigns of 8,275 state-sponsored accounts linked to Russia, Iran and Venezuela as part of the investigation on the foreign interference in the 2016 US election. These data serve as ground-truth identifier of troll users in our dataset. Using graph analysis techniques we qualify the diffusion cascades of web and media context that have been shared by the troll accounts. We present strong evidence that authentic users were the source of the viral cascades. Although the trolls were participating in the viral cascades, they did not have a leading role in them and only four troll accounts were truly influential.
Supplementary file 1 from Rapid functional and evolutionary changes follow gene duplication in yeast
Creators: name: Naseeb, Samina
name: Ames, Ryan M.
name: Delneri, Daniela
name: Lovell, Simon C.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences

description: Duplication of genes or genomes provides the raw material for evolutionary innovation. After duplication a gene may be lost, recombine with another gene, have its function modified, or be retained in an unaltered state. The fate of duplication is usually studied by comparing extant genomes and reconstructing the most likely ancestral states. Valuable as this approach is, it may miss the most rapid evolutionary events. Here, we engineered strains of Saccharomyces cerevisiae carrying tandem and non-tandem duplications of the singleton gene IFA38 to monitor (i) the fate of the duplicates in different conditions, including timescale and asymmetry of gene loss and (ii) the changes in fitness and transcriptome of the strains immediately after duplication and after experimental evolution. We found that the duplication brings widespread transcriptional changes but a fitness advantage is only present in fermentable media. In respiratory conditions, the yeast strains consistently lose the non-tandem IFA38 gene copy in a surprisingly short time, within only few generations. This gene loss appears to be asymmetric and dependent on genome location since the original IFA38 copy and the tandem duplicate are retained. Overall, this work shows for the first time that gene loss can be extremely rapid and context dependent.
Challenges and opportunities in the science of research to practice: lessons learned from a randomized controlled trial of a sexual risk-reduction intervention for psychiatric patients in a public mental health system
Creators: Wainberg, Milton L.
Mann, Claudio G.
Norcini Pala, Andrea
McKinnon, Karen
Pinto, Diana
Pinho, Veronica
Cavalcanti, Maria T.
Leu, Cheng-Shiun
Guimaraes, Mark D.
Mattos, Paulo E.
Hughes, Elizabeth
Palinkas, Lawrence A.
Otto-Salaj, Laura
Remien, Robert H.
Cournos, Francine
PRISSMA Project
Publisher: name: Columbia University
Year: 2020
Subjects: Intervention
Health behavior--Research
HIV infections
Psychotherapy patients

description: Objective: Human immunodeficiency virus (HIV) prevention efficacy trials with psychiatric patients have been conducted in research settings in high-resourced countries, establishing short-term efficacy for reducing sexual risk behavior. None has been implemented within systems of care. In the last decade, overcoming this research-to-practice gap has become a focus of implementation science. This paper describes the first and only HIV Prevention intervention trial for psychiatric patients conducted in real-world outpatient psychiatric settings facilitated by trained clinic-based providers. Methods: The HIV Prevention intervention, which uses the Information-Motivation-Behavioral Skills model to achieve sexual risk-reduction, was rigorously adapted to the local context and clinic services' needs. Participants from eight clinics were randomized to HIV Prevention or Health Promotion conditions. Results: HIV Prevention participants showed significant improvement in Information-Motivation-Behavioral domains; in this group, behavioral intentions were associated with significantly fewer unprotected sex occasions, but reduction of unprotected sex occasions was similar in both conditions. Conclusion: Our trial was conducted before implementation studies became widely funded. Transporting an intervention to a new culture or into real-world practice settings may require adaptations. Our results demonstrate that clear guidelines are needed regarding whether to conduct efficacy, effectiveness, and/or implementation research as the most appropriate next step. Clinical trial registration: NCT00881699.
calculation of confidence intervals for the magnitude of the orientation vector r from Very weak oscillating magnetic field disrupts the magnetic compass of songbird migrants
Creators: name: Pakhomov, Alexander
name: Bojarinova, Julia
name: Cherbunin, Roman
name: Chetverikova, Raisa
name: Grigoryev, Philipp S.
name: Kavokin, Kirill
name: Kobylkov, Dmitry
name: Lubkovskaja, Regina
name: Chernetsov, Nikita
Publisher: name: The Royal Society
Year: 2017
Subjects: Biophysics
Environmental Science

description: There is the procedure for calculation of confidence intervals for the magnitude of the orientation vector r (Fig 7)
Challenges of the Truth Commissions to Deal with Injustice Against Indigenous Peoples
Creators: Librizzi, M. Florencia
Publisher: name: Columbia University
Year: 2014
Subjects: Indigenous peoples--Civil rights
Human rights
Truth commissions
Indians
Indians of North America

description: Truth commissions are still being created around the world in order to redress human rights violations, in accordance to the right of victims to an effective remedy and the right to know the truth to the fullest extent possible. As non-judicial official bodies, which investigate violent historical periods often silenced or denied, truth commissions recognize the dignity of the victims, and propose policies to prevent more violations from happening in the future. Further to that purpose, the recommendations of truth commissions generally seek to identify the causes of the violations, determining patterns of abuse and preventing recurrence.This paper examines some of the challenges that truth commissions face when addressing Indigenous Peoples’ issues, reflecting what measures have to be taken into account in order to establish truth commissions that respect the rights, perspectives and needs of Indigenous Peoples.
Additional file 1 of New insights into the role of cyanide in the promotion of seed germination in tomato
Creators: name: Yu, Lu-Lu
name: Liu, Cui-Jiao
name: Peng, Ye
name: He, Zheng-Quan
name: Xu, Fei
Publisher: name: figshare
Year: 2022
Subjects: subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 1: Table S1. Primers used for qRT-PCR. Figure S1. Hierarchical clustering analysis of the expression profile of each sample. Figure S2. Quantitative analysis of the selected tomato genes by RNA-SEQ and qRT-PCR. Figure S3. KEGG expression profile of the DEGs assigned to ribosome. Figure S4. DEGs related to amino acids biosynthesis and cysteine and methionine metabolism. Figure S5. Heatmaps showing the DEGs related to CTK, ETH, SA, and JA biosynthesis and perception.
Rhabdomyoblasts in Pediatric Tumors: A Review with Emphasis on their Diagnostic Utility
Creators: name: Angelico, Giuseppe
name: Piombino, Eliana
name: Broggi, Giuseppe
name: Motta, Fabio
name: Spadola, Saveria
Publisher: name: figshare
Year: 2017
Subjects: subject: Stem Cells
subject: 100404 Regenerative Medicine (incl. Stem Cells and Tissue Engineering)
subject: FOS: Medical biotechnology

description: Rhabdomyosarcoma is a soft tissue pediatric sarcoma composed of cells which show morphological, immunohistochemical and ultrastructural evidence of skeletal muscle differentiation. To date four major subtypes have been recognized: embryonal, alveolar, spindle cell/sclerosing and pleomorphic. All these subtypes are defined, at least in part, by the presence of rhabdomyoblasts, i.e. cells with variable shape, densely eosinophilic cytoplasm with occasional cytoplasmic cross-striations and eccentric round nuclei. It must be remembered, however, that several benign and malignant pediatric tumours other than rhabdomyosarcoma may exhibit rhabdomyoblaststic and skeletal muscle differentiation. This review focuses on the most common malignant pediatric neoplasm that may exhibit rhabdomyoblastic differentiation, with an emphasis on the most important clinicopathological and differential diagnostic considerations.
title: Early Modern Digital Review, Vol 2 No 4 (2019)
title: Early Modern Digital Review
titleType: AlternativeTitle
Creators: name: Early Modern Digital Review
Publisher: name: Early Modern Digital Review
Year: 2020

description: Introduction: Special Issue, Women’s Authorial Agency and Print Culture Women Writers Online Margaret Cavendish’s Poems and Fancies: A Digital Critical Edition The Reception & Circulation of Early Modern Women’s Writing, 1550–1700 PLRE.Folger: Private Libraries in Renaissance England Mapping the Republic of Letters The Recusant Print Network Project (Beta)
Circuits of Victory: L'Entreprise Bell et L'Engagement du Signal Corps en France
Creators: John, Richard R.
Laborie, Léonard
Publisher: name: Columbia University
Year: 2020
Subjects: Telecommunication systems
Telecommunication systems--Standards
Telephone systems
World War (1914-1918)

description: Le Signal Corps était très lié aux entreprises privées qui, aux États-Unis, construisaient et exploitaient les réseaux de communication télégraphiques et téléphoniques – à la différence de l’Europe où la plupart des réseaux étaient exploités par l’État. Un tiers des effectifs du Signal Corps pendant la guerre provenait de l’entreprise Bell et de ses rivales sur le marché américain, entreprises dites indépendantes car séparées et à la marge du système établi par Vail. Du côté de Bell, l’ingénieur en chef John Carty fut chargé des préparatifs dès avant l’entrée en guerre, puis de l’exécution du plan de mobilisation des troupes réservistes. L’enjeu était de mobiliser aux États-Unis et d’envoyer en Europe les hommes les plus compétents techniquement, pendant que les nouvelles recrues moins expérimentées seraient formées dans leur pays (et aussi plus tard en France). L’intrication entre public et privé qui caractérisait cette arme est bien illustrée par le fait qu’à l’entrée en guerre, les managers des entreprises restèrent dans leurs bureaux, changeant simplement leur tenue civile pour l’uniforme. Cet épisode et plus largement les relations nouées entre Bell et le Signal Corps pendant la guerre font partie des actes fondateurs du complexe militaro-industriel américain contemporain.
Additional file 1 of Accelerometer-measured physical activity, sedentary behavior, and risk of incident pelvic organ prolapse: a prospective cohort study in the UK Biobank
Creators: name: Si, Keyi
name: Cao, Zhi
name: Liu, Qianqian
name: Yang, Yingying
name: Dai, Qingqiang
name: Yao, Yuting
name: Qiao, Yingying
name: Xu, Chenjie
name: Wu, Guizhu
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 1: Checklist. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE). Figure S1. Directed acyclic graph to guide covariate selection. Figure S2. Stratified analyses of the association between LPA (per 1 h/day increment) and the risk of POP. Figure S3. Stratified analyses of the association between MPA (per 30 min/day increment) and the risk of POP. Figure S4. Stratified analyses of the association between VPA (per 15 min/day increment) and the risk of POP. Figure S5. Stratified analyses of the association between sedentary behavior (per 1h/day increment) and the risk of POP. Figure S6. Dose-response association of PA and sedentary behavior with the risk of POP after excluding participants who were diagnosed with POP in the first two years of follow-up (N=47,190). Figure S7. Dose-response association between PA and the risk of POP with mutual adjustment (N=47,674). Figure S8. Dose-response association of PA and sedentary behavior with the risk of POP in complete cases (N=46,283). Table S1. Participant characteristics by inclusion status. Table S2. Joint association of LPA and MPA with the risk of POP. Table S3. Joint association of LPA and VPA with the risk of POP. Table S4. Joint association of MPA and VPA with the risk of POP. Table S5. Association of PA and sedentary behavior with the risk of POP after excluding participants who were diagnosed with POP in the first two years of follow-up (N=47,190). Table S6. Association of PA and sedentary behavior with the risk of POP in competing risk models (N=47,674). Table S7. Association between PA and the risk of POP with mutual adjustment (N=47,674). Table S8. Association of PA and sedentary behavior with the risk of POP in complete cases (N=46,283).
The Femoral Head of Patients with Hip Dysplasia is not as Osteogenic as Iliac Crest Bone Location
Creators: name: Homma, Yasuhiro
name: Dubory, Arnaud
name: Pariat, Jacques
name: Potage, Damien
name: Lachaniette, Charles Henri Flouzat
name: Chevallier, Nathalie
name: Rouard, Helene
name: Hernigou, Philippe
Publisher: name: figshare
Year: 2017
Subjects: subject: Stem Cells
subject: 100404 Regenerative Medicine (incl. Stem Cells and Tissue Engineering)
subject: FOS: Medical biotechnology

description: When Total Hip Arthroplasty (THA) is required in a patient with developmental dysplasia of the hip (DDH), bone deficiency in the acetabular roof often remains a problem. The iliac crest (IC) has long been the preferred source of autograft material, but graft harvest is associated with frequent complications and pain. Autologous bone graft can also be obtained from the femoral head (FH) for reconstruction of the acetabulum in hip arthroplasty. However, in certain challenging clinical scenarios, incorporation of the femoral head autograft appears less successful than the iliac crest autograft. The difference in potential for proliferation and osteoblastic differentiation between the two sites has still not been evaluated; therefore, it is not known how to compensate for this difference when it is present. We designed this study to evaluate the number of mesenchymal stem cells (MSCs) in both the iliac crest and femoral head of the same patient. We also determined the best operating room procedure for loading the femoral head with MSCs to achieve equivalent numbers of MSCs as in the IC. Twenty patients (8 men and 16 women) undergoing THA for DDH were enrolled in the study. The mean age was 55.5 years (range 41–65 years). Bone marrow aspirates were obtained from three depths within the femoral head and the aspirates were quantified relative to matched iliac crest aspirates that were obtained from the same patient at the same time. The cell count, progenitor cell concentration (cells/mL marrow), and progenitor cell prevalence (progenitor cells/million nucleated cells) were calculated.
Aspirates of FH marrow demonstrated less concentrations of mononuclear cells compared with matched controls from the iliac crest. Progenitor cell concentrations were consistently lower in FH aspirates compared to matched controls from the iliac crest (p = 0.05). The concentration of osteogenic progenitor cells was, on average, 40% lower in the FH aspirates than in the paired iliac crest samples (p = 0.05). However, with bone marrow aspirated from the iliac crest, we were able to load the femoral head autograft with sufficient MSCs to obtain the same number as present in an iliac crest. With concentrated bone marrow from the IC, supercharging the femoral autograft with MSCs to numbers above that present in the IC was possible in the operating room, and the number of MSCs supercharged in the femoral head was predictable.
Based on these findings we suggest that FH graft supercharged with BM-MSCs from the IC is comparable to IC graft for osseous graft supplementation especially in THA for patients with DDH.
Clinical–Pathological Agreement in Dementing Disorders: Embracing the Complexity
Creators: Huey, Edward D.
Publisher: name: Columbia University
Year: 2014
Subjects: subject: Neurosciences
subject: FOS: Clinical medicine
subject: Medicine

description: This editorial was written in response to: Giorelli M, Losignore NA, Bagnoli J, et al. The progression of posterior cortical atrophy to corticobasal syndrome: Lumping or splitting neurodegenerative diseases? Tremor Other Hyperkinet Mov. 2014; 4. doi: 10.7916/D81G0JCQ
A new cucurbitane − type triterpenoid from the bark of Elaeocarpus hygrophilus Kurz.
Creators: name: Nguyen, Thi-Ngoc-Nuong
name: Vo, Thi-Nga
name: Nguyen, Kim-Phi-Phung
name: Nguyen, Tri-Hieu
name: Nguyen, Thi-Anh-Tuyet
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Space Science
Pharmacology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Developmental Biology
Cancer
Virology

description: A new cucurbitacin, 3β-(β-D-glucopyranosyloxy)-5β,6β:16α,23α-diepoxycucurbit-24-en-11-one or hygrocucurbin A (1), along with two known compounds, including 3β-(β-D-glucopyranosyloxy)-16α,23α-epoxycucurbita-5,24-dien-11-one (2) and (+)-lyoniresinol (3), were isolated from the bark of Elaeocarpus hygrophilus. Their chemical structures were elucidated by spectroscopic NMR, HR-IDA- TOF-MS analysis, and by comparison with the spectral data of corresponding compounds in the literature. Two cucurbitacins (1) and (2) were evaluated for their α-glucosidase inhibitory activity and cytotoxic against KB, MCF-7, Hep G2, and A549 cancer cell lines. For the α-glucosidase inhibitory activity, compound 1 showed an equivalent effect (IC50 197.4 ± 4.1 µM) compared to the acarbose, a positive control (IC50 208.5 ± 4.7 µM). And for the cytotoxicity, 2 was inactive while 1 was slightly sensitive against KB cells (IC50 233.3 ± 2.5 µM).
A Short Synthesis Concerning Biological Effects and Equivalent Doses in Radiotherapys
Creators: name: Voyant, Cyril
name: Julian, Daniel
Publisher: name: figshare
Year: 2017
Subjects: subject: 111208 Radiation Therapy
subject: FOS: Clinical medicine
subject: 110320 Radiology and Organ Imaging

description: The limits of classical equivalent computation based on time, dose, and fractionation (TDF) and linear quadratic models have been known for a long time. Medical physicists and physicians are required to provide fast and reliable interpretations regarding the delivered doses or any future prescriptions relating to treatment changes. In this letter, we propose an outline related to the different models usable for equivalent and biological doses that are likely to be the most appropriate. The used methodology is based on: the linear-quadratic-linear model of Astrahan, the repopulation effects of Dale, and the prediction of multi-fractionated treatments of Thames.
Coexisting serpentine and quartz from carbonate-bearing serpentinized peridotite in the Samail Ophiolite, Oman
Creators: Streit, Elisabeth Elaine
Kelemen, Peter B.
Eiler, John
Publisher: name: Columbia University
Year: 2012
Subjects: subject: Ophiolites
subject: Serpentinite
subject: Peridotite
subject: Mineralogy
subject: Geochemistry
subject: FOS: Earth and related environmental sciences

description: Tectonically exposed mantle peridotite in the Oman Ophiolite is variably serpentinized and carbonated. Networks of young carbonate veins are prevalent in highly serpentinized peridotite, particularly near low-temperature alkaline springs emanating from the peridotite. An unusual feature in some samples is the coexistence of serpentine and quartz, which is not commonly observed in serpentinites. This assemblage is unstable with respect to serpentine + talc or talc + quartz under most conditions. Serpentine in the carbonated serpentinites in this study is more iron rich than in most serpentinites reported in previous studies, and samples with co-existing quartz contain the most iron-rich serpentines. Calculations of thermodynamic equilibria in the MgO–SiO2–H2O–CO2 system suggest that serpentine + quartz may be a stable assemblage at low temperatures (e.g.,
Metallic Ureteric Stents a cost-effective alternative in the management of Obstructed Distal Ureters
Creators: name: Lang, Erich K
Publisher: name: figshare
Year: 2017
Subjects: subject: 111208 Radiation Therapy
subject: FOS: Clinical medicine
subject: 110320 Radiology and Organ Imaging

description: Management of obstruction of the distal-pelvic ureters by minimally invasive procedures such as antigrade or retrograde double “J” stents has generally been unsatisfactory. Corrective surgical procedures mandate long hospitalization, hence high cost, and have a moderate incidence of complications.
Molecular docking of quercetin: a promising approach for the development of new anti-inflammatory and analgesic drugs
Creators: name: Ettitaou, Amina
name: Kabdy, Hamid
name: Oubella, Khadija
name: Raoui, Karima
name: Oubahmane, Mehdi
name: Aboufatima, Rachida
name: Elyazouli, Loubna
name: Garzoli, Stefania
name: Chait, Abderrahman
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: The aim of this study is to investigate the antinociceptive, anti-inflammatory and antipyretic effects of quercetin. Additionally, molecular docking studies were conducted to evaluate potential interactions between quercetin and various molecular targets. Animal models were used to conduct a comprehensive pharmacological investigation of quercetin. Evaluation of analgesic activity revealed a reduction in the number of abdominal cramps during the twisting test and inhibition of pain during the second phase of the formaldehyde test. Additionally, evaluation of its anti-inflammatory activity showed a reduction in ear oedema. However, it is important to note that quercetin administration has not been shown to significantly reduce yeast-induced hyperthermia. The docking study revealed the high inhibitory potential of quercetin against the COX-2 receptor.
Time to Terminate LNT: Radiation Regulators Should Adopt LT
Creators: name: Siegel, Jeffry A
name: Sacks, Bill
name: Welsh, James S
Publisher: name: figshare
Year: 2017
Subjects: subject: 111208 Radiation Therapy
subject: FOS: Clinical medicine
subject: 110320 Radiology and Organ Imaging

description: The linear no-threshold hypothesis (LNT)-the basis of radiation regulatory policy-extrapolates from observed high-dose harm to assumed low-dose harm, entailing that all ionizing radiation is harmful, by denying any biological response to damage and asserting cumulative lifetime harm, regardless of dose or dose rate. All aspects of LNT are demonstrably false. There are evolved biological responses that repair or remove radiogenic damage from low doses and dose rates, thereby averting acute harm and precluding the alleged cumulative damage. LNT and its offspring, the “as low as reasonably achievable” principle, do not err on the side of caution; neither is truly conservative. The public needs protection from radiophobia, rather than from low-dose radiation exposure. Neither radiation regulations nor medical practice should be based on LNT, but rather, at least as a first step, on a linear (down to a) threshold (LT) model.
Additional file 9 of Pervasive under-dominance in gene expression underlying emergent growth trajectories in Arabidopsis thaliana hybrids
Creators: name: Yuan, Wei
name: Beitel, Fiona
name: Srikant, Thanvi
name: Bezrukov, Ilja
name: Schäfer, Sabine
name: Kraft, Robin
name: Weigel, Detlef
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 9. Review history.
Commercial Contact and Conflict Prevention: The Georgia-Abkhaz Case
Creators: Phillips, David L.
Publisher: name: Columbia University
Year: 2011
Subjects: International relations
International economic relations
International trade

description: This article explores opportunities for interaction between Georgians and Abkhaz. Recommendations are based on the belief that private sector representatives are well suited to take a cooperative approach to engagement and that, even in the most intractable conflicts, the private sector is primarily interested in market access and a stable environment for doing business. The article does not address questions regarding the political status of Abkhazia nor does it explore security arrangements. Politics and security are considered only to the extent that they impact economic issues.
Inter-Observer Variability of a Commercial Patient Positioning and Verification System in Proton Therapys
Creators: name: Yuanshui Zheng
name: Xiaoning Ding
Publisher: name: figshare
Year: 2017
Subjects: subject: 111208 Radiation Therapy
subject: FOS: Clinical medicine
subject: 110320 Radiology and Organ Imaging

description: Purpose:Accurate patient positioning is crucial in radiation therapy. To fully benefit from the preciseness of proton therapy, image guided patient positioning and verification system is typically utilized in proton therapy. The purpose of this study is to evaluate the inter-observer variability of image alignment using a commercially available patient positioning and verification system in proton therapy.
Methods:The VeriSuite patient positioning and verification system (MedCom GmbH, Darmstadt, Germany) provides a six degrees of freedom correction vector by registering two orthogonal x-ray images to digitally reconstructed radiograph (DRR) images that are rendered in real time from the planning computed tomography (CT) images. Six cases of various disease sites, including brain, head & neck, lung, prostate, pelvis, and bladder, were used in this study. For each case, the planning CT images and a daily orthogonal x-ray portal image pair were loaded into the VeriSuite system. The same set of x-ray images and CT images for each case were reviewed and aligned separately by each of the 10 radiation therapist, following the clinical procedure for the corresponding disease site. The resulting correction vectors were then recorded and analyzed.
Results:Our study shows that the inter-observer variation (One standard deviation) in image alignment using the VeriSuite system ranged from 1.2 to 2.0 mm for translational correction and from 0.6 to 1.3 degrees for rotational correction for the six cases. The use of fiducial markers for prostate patient alignment achieved the least inter-observer variation while the bladder case produced the largest.
Conclusions:Inter-observer variation in image alignment could be relatively large, depending on the complexity of patient anatomy, image alignment approach, and user experience and software limitations. Automatic registration and fiducial markers could potentially be used to align patient more accurately and consistently. To ensure adequate tumor coverage in proton therapy, inter-observer variability in patient alignment should be carefully evaluated and accounted for in patient setup uncertainty analysis and treatment planning margin determination.
Data from: Punctuated equilibria remains the dominant pattern of morphospecies origin in the fossil record: An analysis using the "persistence of ancestor" criterion
Creators: name: Anderson, Brendan
name: Allmon, Warren
Publisher: name: Zenodo
Year: 2025
Subjects: Macroevolution
punctuated equilibria
tempo and mode
evolutionary mode
Cladogenesis
anagenesis

description: Punctuated Equilibria (PE) was presented 50 years ago as an alternative to the widespread assumption that most evolution proceeds by gradual phyletic change within lineages. Unfortunately, PE has been widely misunderstood, misrepresented, and unfairly dismissed since this first publication. We argue that much of this misunderstanding centers around a misinterpretation of the meaning of "mode," and the significance of mode, properly understood, for how we understand macroevolutionary processes. PE proposed that most morphospecies do not show significant anagenetic trends through their stratigraphic ranges, and that most new morphospecies that are recognized arise via cladogenesis. To the degree that this is true, most exploration of disparity-space must be associated with cladogenesis.

We surveyed a sample of the recent paleontological literature to assess the frequency with which new morphospecies appear in the fossil record via anagenesis vs cladogenesis using a persistence of ancestor criterion and found the overwhelmingly dominant mode of species origin to be cladogenesis. This is a valuable but underutilized approach to this problem, which could be exploited with more studies of species-level phylogenies of fossil taxa. Combined with the conclusions of other studies that stasis or non-directional change is common, this finding of the dominance of cladogenesis affirms that PE is very much alive, and of substantial significance for understanding macroevolutionary patterns.
description: Funding provided by: U.S. National Science FoundationROR ID: https://ror.org/021nxhr62Award Number: 2225014
Comparison of Care Patterns and Rehospitalizations for Mechanically Ventilated Patients in New York and Ontario
Creators: Wunsch, Hannah
Hill, Andrea D.
Scales, Damon C.
Fowler, Robert A.
Hua, May
Publisher: name: Columbia University
Year: 2018
Subjects: Hospital patients
Artificial respiration
Intensive care units
Hospital utilization--Length of stay

description: Rationale: Mechanically ventilated patients require complex care and are at high risk for rehospitalization, but different systems of care may result in different hospital discharge practices and rates of rehospitalization. Objectives: To compare lengths of hospitalization, discharge patterns, and rehospitalization rates in New York (NY) in the US and Ontario (ON) in Canada. Methods: We conducted a retrospective cohort study of mechanically ventilated patients who survived an acute care hospitalization in NY or ON from 2010-2012, using linkable administrative healthcare data. Measurements and Main Results: The primary outcome was the cumulative incidence of first rehospitalization within 30 days of discharge, accounting for the competing risk of death. Of 71,063 mechanically ventilated patients in NY, and 41,875 in ON who survived to hospital discharge, median length of initial hospital stay was similar in NY versus ON (15 days, Interquartile range (IQR) 8-28 vs 16 (9-30)), but was systematically shorter in NY when stratified by patient subgroups of different illness severity. Fewer patients in NY were discharged directly home (53.6% versus 71.4%). Of patients in NY, 15,527 (cumulative incidence 21.9%) had a first rehospitalization within 30 days versus 5,531 (cumulative incidence 13.2%) in Ontario, p<0.001. Incidence of rehospitalization was higher in NY across all subgroups assessed, with the greatest differences among patients with a tracheostomy (29.8% versus 13.3%, p<0.001), those who received dialysis during the hospitalization (31.9% versus 17.0%, p<0.001), and for patients not discharged directly home (27.6% versus 13.1% p<0.001). Conclusions: Mechanically ventilated patients who survive to hospital discharge in NY have shorter hospital stays, with higher rehospitalization rates within 30 days compared with ON.
A new sesquiterpene coumarins from Ferula bungeana Kitagawa
Creators: name: Kang, Xiurong
name: Wu, Lili
name: Zhao, Chaoliang
name: Zhang, Chaolumeng
name: Wang, Qinghu
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: A new sesquiterpene coumarin, bungeanin A (1), together with four known sesquiterpene coumarins, were isolated from the whole plants of Ferula bungeana Kitagawa. The structure of bungeanin A was elucidated by analysis of its spectroscopic data, including UV, IR, HR-ESI-MS, and extensive 1D and 2D NMR spectroscopy.
Secondary Onychomycosis Development after Cosmetic Procedure-Case Report
Creators: name: Dyląg, Mariusz
name: Flisowska, Emilia
name: Bielecki, Patryk
name: Kozioł-Gałczyńska, Maria
name: Jasińska, Weronika
Publisher: name: figshare
Year: 2017
Subjects: subject: Health Care
subject: 110310 Intensive Care
subject: FOS: Clinical medicine
subject: 110323 Surgery

description: The authors describe the unusual case of subungual onychomycosis, due to fluconazole and itraconazole resistant Candida albicans after using the hybrid and acrylic lacquers and nail tips. The etiology of these atypical changes was supported by isolation of the fungus from the nail lesions, and its consistent identification by means of morphological and molecular diagnosis. In the presented case, topical treatment with ciclopirox 8% nail lacquer allow to fight the pathogenic fungus but did not restore the natural appearance of the nails.
Conflict, peace and the human rights of Indigenous Peoples
Creators: Tauli-Corpuz, Victoria
Publisher: name: Columbia University
Year: 2017
Subjects: Human rights
Indigenous peoples
Peace
Conflict management

description: Conflicts affecting indigenous peoples can often be traced back to long-standing historical injustices and discrimination originating in the context of colonization and dispossession of indigenous peoples’ lands, territories and resources. Many indigenous peoples reside in ancestral territories that are rich in natural resources. Land disputes are frequently the root cause of conflict as indigenous peoples are faced with dominant and powerful political and economic interests who use the state institutions (e.g., police, military, courts) and state laws to seek control over their lands and exploit their resources. In many instances, there are private interests behind this, and they utilise the presence of armed actors to facilitate land grabbing and exploitation of natural resources such as minerals and metals, oil, gas and coal, timber and water. In other situations, armed groups claim ideological grounds for occupying indigenous lands and seek to involve indigenous peoples in their armed struggle. The often-scarce presence of state institutions and services in indigenous territories leaves indigenous peoples particularly vulnerable to the force of non-state armed actors. In this presentation, I wish to underline the international legal standards applicable in situations of armed conflict and I would like to highlight examples of two countries where indigenous peoples are caught in between on-going hostilities and continue to face serious violations of their rights. The two countries, Colombia and the Philippines, also highlight the challenges indigenous peoples face in the context of peace negotiations and transitional justice.