cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The KSBA compactification for the moduli space of degree two K3 pairs
Creators: name: Laza, Radu
Publisher: name: arXiv
Year: 2012
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: Inspired by the ideas of the minimal model program, Shepherd-Barron, Kollár, and Alexeev have constructed a geometric compactification for the moduli space of surfaces of log general type. In this paper, we discuss one of the simplest examples that fits into this framework: the case of pairs (X,H) consisting of a degree two K3 surface X and an ample divisor H. Specifically, we construct and describe explicitly a geometric compactification $\bar{P_2}$ for the moduli of degree two K3 pairs. This compactification has a natural forgetful map to the Baily-Borel compactification of the moduli space $F_2$ of degree two K3 surfaces. Using this map and the modular meaning of $\bar{P_2}$, we obtain a better understanding of the geometry of the standard compactifications of $F_2$.
description: 45 pages, 4 figures, 2 tables
Additional file 1 of Analysis of cells of epithelial, connective tissue and immune differentiation in HPV-positive-, HPV-negative oropharyngeal carcinoma and normal oropharyngeal tissue by immunofluorescence multiplex image cytometry: a preliminary report
Creators: name: Giotakis, Aris I.
name: Runge, Annette
name: Dudas, József
name: Glueckert, Rudolf
name: Gottfried, Timo
name: Schartinger, Volker H.
name: Klarer, Johanna
name: Randhawa, Avneet
name: Caimmi, Eleonora
name: Riechelmann, Herbert
Publisher: name: figshare
Year: 2023
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Supplementary Material 1
The validity of rheumatoid arthritis diagnoses in Finnish biobanks
Creators: name: Paltta, J
name: Heikkilä, H-K
name: Pirilä, L
name: Eklund, KK
name: Huhtakangas, J
name: Isomäki, P
name: Kaipiainen-Seppänen, O
name: Kristiansson, K
name: Havulinna, AS
name: Sokka-Isler, T
name: Palomäki, A
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Hematology

description: The aim of this study was to determine the validity of rheumatoid arthritis (RA) diagnoses in patients participating in Finnish biobanks. We reviewed the electronic medical records of 500 Finnish biobank participants: 125 patients with at least one visit with a diagnosis of seropositive RA, 125 patients with at least one visit with a diagnosis of seronegative RA, and 250 age- and gender-matched controls. The patients were chosen from five different biobank hospitals in Finland. A rheumatologist reviewed the medical records to assess whether each patients’ diagnosis was correct. The diagnosis was compared with the diagnostic codes in the Finnish Care Register for Health Care (CRHC) and special reimbursement data of the Social Insurance Institution of Finland. The positive predictive value (PPV) of CRHC diagnosis of RA (for seropositive and seronegative RA combined) was 0.82. For patients with a special reimbursement for anti-rheumatic medications for RA, the PPV was 0.89. The PPV was higher in patients with more than one visit. For one, two, five, and 10 visits, the PPV was 0.82, 0.85, 0.89, and 0.90, respectively, and for patients who also had the special reimbursement, the PPV was 0.89, 0.91, 0.93, and 0.94 for one, two, five, and 10 visits, respectively. In patients positive for anti-citrullinated protein antibodies, the PPV was 0.98. These results demonstrate that the validity of RA diagnoses in Finnish biobanks was good and can be further improved by including data on special reimbursement for medication, number of visits, and serological data.
Electrically tunable charge and spin transitions in Landau levels of interacting Dirac fermions in trilayer graphene
Creators: name: Apalkov, Vadim M.
name: Chakraborty, Tapash
Publisher: name: arXiv
Year: 2011
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Trilayer graphene in the fractional Quantum Hall Effect regime displays a set of unique interaction-induced transitions that can be tuned entirely by the applied bias voltage. These transitions occur near the anti-crossing points of two Landau levels. In a large magnetic field ($> 8$ T) the electron-electron interactions close the anti-crossing gap, resulting in some unusual transitions between different Landau levels. For the filling factor $ν=\frac23$, these transitions are accompanied by a change of spin polarization of the ground state. For a small Zeeman energy, this provides an unique opportunity to control the spin polarization of the ground state by fine tuning the bias voltage.
description: 5 pages, 4 figures
Additional file 7 of Definition of the transcriptional units of inherited retinal disease genes by meta-analysis of human retinal transcriptome data
Creators: name: Ruiz-Ceja, Karla Alejandra
name: Capasso, Dalila
name: Pinelli, Michele
name: Del Prete, Eugenio
name: Carrella, Diego
name: di Bernardo, Diego
name: Banfi, Sandro
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 7: Supplementary Table S1. Oligonucleotides primers used in this study. Figure S1. Predicted 3D protein structures encoded by the novel HEITs. Figure S2. Source data for Fig. 3.
title: Configuration files and outputs from a MIKE by DHI hydrodynamic model of the east coast of Scotland
Creators: name: Sabatino, Alessandro
Publisher: name: University of Strathclyde
Year: 2016
Subjects: tides
currents
waves
ocean modelling

description: This dataset contains all the configuration files and input files needed to run a MIKE-by-DHI hydrodynamic model (version 2012) of the east coast of Scotland as described in the publication:
Sabatino, A., McCaig, C., O’Hara Murray, R. & Heath, M.R. (2015). Modelling wave-current interactions off the east coast of Scotland. Ocean Science Discussions http://www.ocean-sci-discuss.net/os-2015-109/

The dataset also contains all of the model outputs for 2008 and 2010 including simulated sea levels, water currents and wave heights and periods, both with and without wave-current interactions implemented in the model.

MIKE-by_DHI is a commercial hydrodynamic modelling package https://www.mikepoweredbydhi.com/products
The licence for this software for use by the University of Strathclyde was obtained as part of the EPSRC Terrawat project.
Sequential ultrasound in arthralgia patients at risk for inflammatory arthritis: is it of added value in risk stratification?
Creators: name: Rogier, C
name: Kortekaas, MC
name: van der Helm-van Mil, AHM
name: de Jong, PHP
name: van Mulligen, E
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Neuroscience
subject: Biotechnology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 60506 Virology

description: Sequential ultrasound in arthralgia patients at risk for inflammatory arthritis: is it of added value in risk stratification?
Cleaning spectroscopic samples of stars in nearby dwarf galaxies: The use of the nIR MgI line to weed out Milky Way contaminants
Creators: name: Battaglia, Giuseppina
name: Starkenburg, Else
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Dwarf galaxies provide insights on the processes of star formation and chemical enrichment at the low end of the galaxy mass function, as well as on the clustering of dark matter on small scales. In studies of Local Group dwarf galaxies, spectroscopic samples of individual stars are used to derive the internal kinematics and abundance properties of these galaxies. It is therefore important to clean these samples from Milky Way stars, not related to the dwarf galaxy, since they can contaminate the analysis of the properties of these objects. Here we introduce a new diagnostic for separating Milky Way contaminant stars -- that mainly constitute of dwarf stars -- and red giant branch stars targeted in dwarf galaxies. As discriminator we use the trends in the equivalent width of the nIR MgI line at 8806.8 Å as a function of the equivalent width of CaII triplet lines. This method is particularly useful for works dealing with multi-object intermediate resolution spectroscopy focusing in the region of the nIR CaII triplet. We use synthetic spectra to explore how the equivalent width of these lines changes for stars with different properties (gravity, effective temperature, metallicity) and find that a discrimination among giants above the horizontal branch and dwarfs can be made with this method at [Fe/H]> -2 dex. For -2 $\le$ [Fe/H] $\le$ -1, this method is also valid to discriminate dwarfs and giants down to approximately one magnitude below the horizontal branch. Using a foreground model we make predictions on the use of this new discrimination method for nearby dwarf spheroidal galaxies, including the ultra-faints. We subsequently use VLT/FLAMES data for the Sextans, Sculptor and Fornax dSphs to verify the predicted theoretical trends.
description: 14 pages, 10 figures. Accepted for publication in A&A
Petrologic and geochemical contraints on genesis of the Jason Pb-Zn deposits, Yukon Territory
Creators: name: Gardner, Howard David, 1956-
Publisher: name: University of Calgary
Year: 1983
Subjects: subject: QE 364 G35 1983
subject: Hydrothermal deposits - Yukon Territory - Macmillan Pass area
subject: Sulphides
subject: Lead ores - Yukon Territory - Macmillan Pass area
subject: Zinc ores - Yukon Territory - Macmillan Pass area

description: Bibliography: p. 176-187.
1923 Salon d'Automne Carte d'Exposant
Creators: name: (:Unav)
Publisher: name: Columbia University
Year: 2018
Subjects: Art--Exhibitions

description: In 1920s-1930s, Lissim participated in group exhibitions in Paris, Berlin, London, Vienna, Barcelona, New York, Riga; had personal exhibitions in various Paris galleries; participated in numerous art shows.
Additional file 1 of Priorities for implementation research on diagnosing cancer in primary care: a consensus process
Creators: name: Willis, Thomas A
name: Neal, Richard D
name: Walter, Fiona M
name: Foy, Robbie
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1: Online survey text
The impact of a structured one–day seminar on disease–specific knowledge, lifestyle habits and disease impairment in ANCA–associated vasculitis. Results of a randomized, controlled study
Creators: name: Garbe, N
name: Schäfer, C
name: Pilz, A
name: Schmidt, F
name: Raberger, K
name: Wienke, A
name: Keyßer, G
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer
subject: Science Policy

description: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a complex, chronic autoimmune disease, and its diagnosis triggers considerable anxiety and uncertainty for those affected. There are currently no valid data describing the impact of disease-specific patient education on the disease knowledge, subjective impairment, and changes in lifestyle habits related to AAV. We designed a one-day educational programme to serve AAV patients with information about their disease and its treatment. Patients were randomized into an intervention group and a waiting list control group. Increase in knowledge was measured with a multiple-choice test. The intervention group completed the questionnaire before, directly after, and 3 months after the seminar, while the waiting list control group was additionally tested 3 months before the seminar to rule out non-specific learning. Furthermore, we investigated the burden of the disease and the impact of our intervention on this burden. Compared with the control group, the intervention increased the knowledge (mean ± sd score difference 2.2 ± 1.0, 95% confidence interval 0.1–4.3, p = 0.04). From the patients’ point of view, their understanding of the disease had improved and the subjective impairment caused by their rheumatic disease had decreased. There was a tendency to include disease-relevant behaviour, such as nasal care or dietary recommendations, more often in everyday life. A one-day seminar is suitable to increase the disease-specific knowledge of patients with AAV in a sustainable manner. In addition, our measure positively affected the disease-relevant behaviour.
Haplotype Inference on Pedigrees with Recombinations, Errors, and Missing Genotypes via SAT solvers
Creators: name: Pirola, Yuri
name: Della Vedova, Gianluca
name: Biffani, Stefano
name: Stella, Alessandra
name: Bonizzoni, Paola
Publisher: name: arXiv
Year: 2011
Subjects: subject: Data Structures and Algorithms (cs.DS)
subject: Populations and Evolution (q-bio.PE)
subject: FOS: Computer and information sciences
subject: FOS: Biological sciences
subject: F.2.2

description: The Minimum-Recombinant Haplotype Configuration problem (MRHC) has been highly successful in providing a sound combinatorial formulation for the important problem of genotype phasing on pedigrees. Despite several algorithmic advances and refinements that led to some efficient algorithms, its applicability to real datasets has been limited by the absence of some important characteristics of these data in its formulation, such as mutations, genotyping errors, and missing data. In this work, we propose the Haplotype Configuration with Recombinations and Errors problem (HCRE), which generalizes the original MRHC formulation by incorporating the two most common characteristics of real data: errors and missing genotypes (including untyped individuals). Although HCRE is computationally hard, we propose an exact algorithm for the problem based on a reduction to the well-known Satisfiability problem. Our reduction exploits recent progresses in the constraint programming literature and, combined with the use of state-of-the-art SAT solvers, provides a practical solution for the HCRE problem. Biological soundness of the phasing model and effectiveness (on both accuracy and performance) of the algorithm are experimentally demonstrated under several simulated scenarios and on a real dairy cattle population.
description: 14 pages, 1 figure, 4 tables, the associated software reHCstar is available at http://www.algolab.eu/reHCstar
Elementary excitations and the phase transition in the bimodal Ising spin glass model
Creators: name: Jinuntuya, N.
name: Poulter, J.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We show how the nature of the the phase transition in the two-dimensional bimodal Ising spin glass model can be understood in terms of elementary excitations. Although the energy gap with the ground state is expected to be 4J in the ferromagnetic phase, a gap 2J is in fact found if the finite lattice is wound around a cylinder of odd circumference $L$. This 2J gap is really a finite size effect that should not occur in the thermodynamic limit of the ferromagnet. The spatial influence of the frustration must be limited and not wrap around the system if $L$ is large enough. In essence, the absence of 2J excitations defines the ferromagnetic phase without recourse to calculating magnetisation or investigating the system response to domain wall defects. This study directly investigates the response to temperature. We also estimate the defect concentration where the phase transition to the spin glass glass state occurs. The value $p_c = 0.1045(11)$ is in reasonable agreement with the literature.
description: 7 pages, 11 figures
On the well-posedness of a mathematical model describing water-mud interaction
Creators: name: Escher, Joachim
name: Matioc, Anca-Voichita
Publisher: name: arXiv
Year: 2012
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35A39, 76A05, 35R57, 76T99

description: In this paper we consider a mathematical model describing the two-phase interaction between water and mud in a water canal when the width of the canal is small compared to its depth. The mud is treated as a non-Netwonian fluid and the interface between the mud and fluid is allowed to move under the influence of gravity and surface tension. We reduce the mathematical formulation, for small boundary and initial data, to a fully nonlocal and nonlinear problem and prove its local well-posedness by using abstract parabolic theory.
description: 16 pages
Psoriatic arthritis, axial spondyloarthritis and rheumatoid arthritis in Norway: nationwide prevalence and use of biologic agents
Creators: name: Kerola, AM
name: Rollefstad, S
name: Kazemi, A
name: Wibetoe, G
name: Sexton, J
name: Mars, N
name: Kauppi, M
name: Kvien, TK
name: Haavardsholm, EA
name: Semb, AG
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: To estimate the prevalence of psoriatic arthritis (PsA), axial spondyloarthritis (axSpA) and rheumatoid arthritis (RA) and the use of biologic agents in these diseases in Norway. From the Norwegian Patient Registry (NPR), we identified as PsA, axSpA and RA patients ≥18 years those with ≥2 recorded episodes with diagnostic coding for index disease (L40.5, M07.0-M07.3 for PsA; M45, M46.0, M46.1, M46.8 and M46.9 for axSpA; M05-M06 for RA). We calculated the point prevalence of PsA, axSpA and RA as per the 1st of January 2017 in the Norwegian adult population (age ≥18). Dispensed disease-modifying antirheumatic drug (DMARD) prescriptions were obtained from the Norwegian Prescription Database and biologic DMARDs given in hospitals from the NPR. The point prevalence of PsA, axSpA, RA, and any of these diseases in total was 0.46%, 0.41%, 0.78%, and 1.56%, respectively. Among women, the prevalence of PsA, axSpA, and RA was 0.50%, 0.37%, and 1.10%, and among men 0.43%, 0.45%, and 0.46%, respectively. In 2017, 27.3% of RA patients, 25.7% of PsA patients and 35.1% of axSpA patients used biologic DMARDs. Treatment with biologics was more frequent in younger age groups in all three diseases, and became more infrequent especially after age ≥55 years. In Norway, the combined prevalence of PsA, axSpA, and RA was over 1.5%. Reflecting the good overall access to highly effective but costly biologic treatments, more than a fourth of these patients used biologic agents, which corresponds to over 0.4% of Norwegian adult population.
Additional file 1 of The unique role of smartphone addiction and related factors among university students: a model based on cross-sectional and cross-lagged network analyses
Creators: name: Liu, Cunjia
Publisher: name: figshare
Year: 2023
Subjects: Biological Sciences not elsewhere classified
Science Policy
Mental Health

description: Additional file 1: Appendix Fig. A1. The cross-lagged panel network estimations of smartphone addiction and its influencing factors among university students from T1 to T2.
Unquenching the gluon propagator with Schwinger-Dyson equations
Creators: name: Aguilar, A. C.
name: Binosi, D.
name: Papavassiliou, J.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this article we use the Schwinger-Dyson equations to compute the nonperturbative modifications caused to the infrared finite gluon propagator (in the Landau gauge) by the inclusion of a small number of quark families. Our basic operating assumption is that the main bulk of the effect stems from the "one-loop dressed" quark loop contributing to the full gluon self-energy. This quark loop is then calculated, using as basic ingredients the full quark propagator and quark-gluon vertex; for the quark propagator we use the solution obtained from the quark gap equation, while for the vertex we employ suitable Ansätze, which guarantee the transversality of the answer. The resulting effect is included as a correction to the quenched gluon propagator, obtained in recent lattice simulations. Our main finding is that the unquenched propagator displays a considerable suppression in the intermediate momentum region, which becomes more pronounced as we increase the number of active quark families. The influence of the quarks on the saturation point of the propagator cannot be reliably computed within the present scheme; the general tendency appears to be to decrease it, suggesting a corresponding increase in the effective gluon mass. The renormalization properties of our results, and the uncertainties induced by the unspecified transverse part of the quark-gluon vertex, are discussed. Finally, the dressing function of the gluon propagator is compared with the available unquenched lattice data, showing rather good agreement.
description: 40 pages, 17 figures
Non-factorizable effects in top quark production
Creators: name: Rosner, Jonathan L.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The production of top-antitop pairs at the Fermilab Tevatron shows a forward-backward asymmetry in which the top quark tends to follow the proton direction, while the antitop tends to follow the antiproton direction. The effect grows with increasing effective mass $m_{t \bar t}$ of the top-antitop pair, and with increasing rapidity difference between the top and antitop. The observed effect is about three times as large as predicted by next-to-leading-order QCD, but with the same sign. An estimate of non-factorizable effects based on a QCD string picture finds they are negligible, but that small distortions of the $m_t$ spectrum are possible. Tests for such effects, both at and above the level of this estimate, are suggested.
description: 7 pages, 1 figure. Added text and references. Submitted to Phys. Rev. D
Ramanujan series upside-down
Creators: name: Guillera, Jesús
name: Rogers, Mathew
Publisher: name: arXiv
Year: 2012
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: We prove that there is a correspondence between Ramanujan-type formulas for 1/π, and formulas for Dirichlet L-values. The same method also allows us to resolve certain values of the Epstein zeta function in terms of rapidly converging hypergeometric functions. The Epstein zeta functions were previously studied by Glasser and Zucker.
description: 28 pages
Transfer of habituation in Aplysia californica: evidence for a heterosynaptic mechanism underlying habituation of the gill-withdrawal reflex
Creators: name: Goldberg, Jeffrey I.
Publisher: name: University of Calgary
Year: 1983
Subjects: subject: QP 374 G64 1985
subject: Habituation (Neuropsychology)
subject: Neural transmission
subject: Aplysia
subject: Gills
subject: Nervous system - Mollusks

description: Bibliography: p. 193-209.
Purification of nuclear envelopes from three cell lines of the Shionogi mouse mammary carcinoma and preliminary characterization of androgen binding
Creators: name: Golsteyn, Elizabeth Jean, 1958-
Publisher: name: University of Calgary
Year: 1983
Subjects: subject: QH 601.2 G64 1986
subject: Nuclear membranes
subject: Cell lines
subject: Steroid hormones
subject: Androgens

description: Bibliography: p. 172-185.
New approach to the use of propolis against dermatomycosis
Creators: name: Galinari, Camila B.
name: Conrado, Pollyanna C. V.
name: Sakita, Karina M.
name: Arita, Glaucia S.
name: Melo, Raquel C.
name: Capoci, Isis Regina
name: Santos, Rafaela S. dos
name: Bruschi, Marcos L.
name: Kioshima, Erika S.
name: Svidzinski, Terezinha I. E.
name: de S. Bonfim-Mendonça, Patrícia
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified

description: In recent years, propolis extract (PE) has demonstrated antimicrobial and anti-inflammatory properties. The aim of this study was to evaluate the antifungal activity of a bioadhesive thermoresponsive system containing 16% propolis (BTSP 16%) against Microsporum canis, Nannizzia gypsea, Trichophyton mentagrophytes and T. rubrum. We also evaluated PE alone against the same strains. The results showed that both PE and BTSP 16% significantly reduced the fungal viability of all evaluated strains. In addition, they interacted with the biofilm of these species in different stages of biofilm formation. We observed that the bioadhesive and thermoresponsive properties of BTSP 16% prolonged propolis presence at infection sites, leading to positive results against planktonic fungal cells and mature biofilms. These characteristics make this formulation a valuable alternative treatment for dermatomycosis.
Additional file 1 of Diabetes and anti-diabetic interventions and the risk of gynaecological and obstetric morbidity: an umbrella review of the literature
Creators: name: Semertzidou, Anita
name: Grout-Smith, Harriet
name: Kalliala, Ilkka
name: Garg, Akanksha
name: Terzidou, Vasso
name: Marchesi, Julian
name: MacIntyre, David
name: Bennett, Phillip
name: Tsilidis, Konstantinos
name: Kyrgiou, Maria
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy

description: Additional file 1. Search Algorithm.
Elevated Fab glycosylation of anti-hinge antibodies
Creators: name: Koers, J
name: Derksen, NIL
name: Falkenburg, WJJ
name: Heer, P Ooijevaar-de
name: Nurmohamed, MT
name: Wolbink, GJ
name: Rispens, T
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Neuroscience
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology

description: Rheumatoid arthritis (RA) is characterized by systemic inflammation and the presence of anti-citrullinated protein antibodies (ACPAs), which contain remarkably high levels of Fab glycosylation. Anti-hinge antibodies (AHAs) recognize immunoglobulin G (IgG) hinge neoepitopes exposed following cleavage by inflammation-associated proteases, and are also frequently observed in RA, and at higher levels compared to healthy controls (HCs). Here, we investigated AHA specificity and levels of Fab glycosylation as potential immunological markers for RA. AHA serum levels, specificity, and Fab glycosylation were determined for the IgG1/4-hinge cleaved by matrix metalloproteinase-3, cathepsin G, pepsin, or IdeS, using enzyme-linked immunosorbent assay and lectin affinity chromatography, in patients with early active RA (n = 69) and HCs (n = 97). AHA reactivity was detected for all hinge neoepitopes in both RA patients and HCs. Reactivity against CatG-IgG1-F(ab´)2s and pepsin-IgG4-F(ab´)2s was more prevalent in RA. Moreover, all AHA responses showed increased Fab glycosylation levels in both RA patients and HCs. AHA responses are characterized by elevated levels of Fab glycosylation and highly specific neoepitope recognition, not just in RA patients but also in HCs. These results suggest that extensive Fab glycosylation may develop in response to an inflammatory proteolytic microenvironment, but is not restricted to RA.
Effects of local heating and premelting in the terminal part of the e$^+$ track
Creators: name: Zvezhinskiy, Dmitry S.
name: Stepanov, Sergey V.
name: Byakov, Vsevolod M.
name: Zgardzinska, Bozena
Publisher: name: arXiv
Year: 2012
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Due to the ionizations promoted by the slowing down of energetic positron and subsequent ion-electron recombinations, positron releases up to 1 keV in the terminal blob region [1]. After all this energy converts into heat. This local heating effect makes the medium to heat up and melt, especially at the region where the bulk temperature of the medium is close (but slightly below) the phase transition temperature. In this case this effect leads to a peculiar temperature dependence of the lifetime of the long-lived LT spectra component. We introduce a model to describe the temperature behaviour of the ortho-positronium lifetime for three simple alcohols (methanol, ethanol and butanol) at the melting range.
Increased synovial galectin-3 induce inflammatory fibroblast activation and osteoclastogenesis in patients with rheumatoid arthritis
Creators: name: Nielsen, MA
name: Køster, D
name: Greisen, S
name: Troldborg, A
name: Stengaard-Pedersen, K
name: Junker, P
name: Hørslev-Petersen, K
name: Hetland, ML
name: Østergaard, M
name: Hvid, M
name: Leffler, H
name: Kragstrup, TW
name: Deleuran, B
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Plant Biology

description: Galectin-3 (Gal-3) has been suggested as a proinflammatory mediator in rheumatoid arthritis (RA). We aimed to study clinical and pathogenic aspects of Gal-3 in RA. Plasma samples from healthy controls (n = 48) and patients with newly diagnosed, early RA were assayed for soluble Gal-3. In patients with chronic RA (n = 18), Gal-3 was measured in both plasma and synovial fluid. Synovial fluid mononuclear cells were used to purify fibroblast-like synoviocytes (FLSs) and osteoclasts. Monocultures of FLSs and autologous co-cultures of FLSs and peripheral blood mononuclear cells were established and co-incubated with a Gal-3 inhibitor. Patients with early and chronic RA had persistently increased plasma levels of Gal-3 compared with controls. However, changes in plasma Gal-3 at the level of individuals were associated with long-term disease activity. In seropositive early RA patients, all patients with decreasing plasma Gal-3 from 0 to 3 months had low disease activity after 2 years (p < 0.05). Gal-3 levels in synovial fluid were markedly elevated. In vitro, co-incubation with a Gal-3 inhibitor (GB1107, 10 µM) led to a significant reduction in both interleukin-1β and tumour necrosis factor-α secretion from FLS monocultures (both p < 0.05) and decreased monocyte-derived osteoclastogenesis compared with controls (both p < 0.05). Our findings underscore the role of Gal-3 regarding disease activity and tissue destruction in RA. An initial decrease in plasma Gal-3 levels predicted decreased long-term disease activity. Correspondingly, a Gal-3 inhibitor decreased the activity of inflammatory FLSs and osteoclastogenesis in patients with RA.
Prevalence of joint, entheseal, tendon, and bursal findings in young, healthy individuals by musculoskeletal ultrasound
Creators: name: Schreiner, JK
name: Scheicht, D
name: Karakostas, P
name: Recker, F
name: Ziob, J
name: Behning, C
name: Preuss, P
name: Brossart, P
name: Schäfer, VS
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Biotechnology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine

description: The purpose of this study was to determine the prevalence of joint, enthesis, bursa, and tendon ultrasound findings in large and medium joints of young, healthy individuals. Ultrasound assessment of large and medium joints, bursae, tendons, and entheses was performed in healthy individuals below the age of 30 years. Participants also underwent bioelectrical impedance analysis and conducted supervised weight training to determine maximum strength. The prevalence of ultrasound findings was calculated and a binary logistic regression model was applied to evaluate factors associated with the present findings. Fifty-one healthy individuals (52.9% female) with a mean age of 23.7 years were included in this study. Joint effusion in at least one joint was observed in 72.6% of the individuals (n = 37) and entheseal pathology in at least one enthesis was detected in 27.5% (n = 14). A binary logistic regression model indicated a significant association between reported hours of sports activity per week and the prevalence of effusion in the knee (p = 0.017). In addition, associations were observed between entheseal pathology in at least one entheseal site and body mass index (BMI) (p = 0.015) as well as fat mass index (p = 0.026). Joint effusion in large and medium joints, as well as entheseal hyperperfusion, bursal effusion, and tendon sheath effusion, are found in healthy individuals. Hours of sports activity per week, BMI and fat mass index showed significant associations with the findings in joints and entheses.
The Relationship between learning styles and career exploration
Creators: name: Grant, Catherine R. E. (Catherine Ruth Elizabeth), 1940-
Publisher: name: University of Calgary
Year: 1983
Subjects: subject: LC 1044 G72 1986
subject: Vocational education - Evaluation
subject: Career Exploration Module System
subject: Kolb's Learning Styles Inventory
subject: Learning, Psychology of

description: Bibliography: p. 78-91.
title: Massively parallel next generation sequencing to investigate the cis- and trans-acting genetic modifiers of somatic instability in Huntington’s disease
Creators: name: Alshammari, Asma Mubarak
Publisher: name: University of Glasgow
Year: 2018
Subjects: subject: Huntington's disease, next generation sequencing, MiSeq, triplet repeat, microsatelite.

description: Huntington disease (HD) is an extremely variable inherited neurodegenerative disorder caused by expansion of an unstable CAG trinucleotide repeat in the huntingtin gene (HTT). Somatic instability in HD exhibits an age-dependent, expansion-biased and tissue-specific pattern, and the highest level of somatic instability is found in tissues that are most susceptible to the disease pathology. Therefore, the aim of this project was to test the hypothesis that somatic instability of the HD CAG repeat plays a major role in disease pathology by quantifying somatic instability in the number of CAG repeats by next generation sequencing (NGS) technology in buccal cell DNA. We developed a method to sequence and genotype HTT alleles from blood and buccal swab DNA of the Scottish and Venezuelan populations respectively. A total of 210 individuals from the Scottish general population and 742 HD patients and unaffected individuals from the Venezuelan HD cohort were sequenced on the MiSeq platform. We established that it was possible to sequence and genotype the CAG repeats, the polymorphic CCG repeat and the flanking sequences. Our data highlight the utility of NGS technology as an approach to genotype HTT alleles, detect sequence variants and quantify somatic instability of the CAG repeat. Our data emphasise that the somatic instability in HD is age-dependent and expansion-biased, also could be a major factor in disease progression, and could be a potential therapeutic target in HD. We also investigated the possibility that there are trans-acting modifier factors involved in determining the degree of somatic instability in HD patients. We genotyped polymorphisms in candidate mismatch repair (MMR) genes and examined their effect, if any, on the residual variation of somatic instability. Individuals carrying the minor allele of rs3512 in FAN1 have a higher level of somatic instability than average, suggesting that some of the variations in HD somatic instability could be accounted for by genetic variation in the DNA mismatch repair pathway. The search for modifier genes might have consequences in understanding the pathological process in HD, and may therefore provide therapeutic targets for future investigations.
Additional file 2 of Diabetes and anti-diabetic interventions and the risk of gynaecological and obstetric morbidity: an umbrella review of the literature
Creators: name: Semertzidou, Anita
name: Grout-Smith, Harriet
name: Kalliala, Ilkka
name: Garg, Akanksha
name: Terzidou, Vasso
name: Marchesi, Julian
name: MacIntyre, David
name: Bennett, Phillip
name: Tsilidis, Konstantinos
name: Kyrgiou, Maria
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy

description: Additional file 2: Table S1A. Description of 47 meta-analyses results investigating the association of diabetes with gynaecological and obstetric morbidity- cohort studies only.
Additional file 1 of Perception of nudge interventions to mitigate medication errors risk in healthcare service delivery
Creators: name: Chew, Keng Sheng
name: Ooi, Say Keat
name: Abdul Rahim, Noor Fareen
name: Wong, Shirly Siew-Ling
name: Kandasamy, Vanitha
name: Teo, Shin-Shin
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Supplementary Material 1
Onsager approach to 1D solidification problem and its relation to phase field description
Creators: name: Brener, Efim A.
name: Temkin, D. E.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We give a general phenomenological description of the steady state 1D front propagation problem in two cases: the solidification of a pure material and the isothermal solidification of two component dilute alloys. The solidification of a pure material is controlled by the heat transport in the bulk and the interface kinetics. The isothermal solidification of two component alloys is controlled by the diffusion in the bulk and the interface kinetics. We find that the condition of positive-definiteness of the symmetric Onsager matrix of interface kinetic coefficients still allows an arbitrary sign of the slope of the velocity-concentration line near the solidus in the alloy problem or of the velocity-temperature line in the case of solidification of a pure material. This result offers a very simple and elegant way to describe the interesting phenomenon of a possible non-single-value behavior of velocity versus concentration which has previously been discussed by different approaches. We also discuss the relation of this Onsager approach to the thin interface limit of the phase field description.
description: 5 pages, 1 figure, submitted to Physical Review E
Additional file 3 of Diabetes and anti-diabetic interventions and the risk of gynaecological and obstetric morbidity: an umbrella review of the literature
Creators: name: Semertzidou, Anita
name: Grout-Smith, Harriet
name: Kalliala, Ilkka
name: Garg, Akanksha
name: Terzidou, Vasso
name: Marchesi, Julian
name: MacIntyre, David
name: Bennett, Phillip
name: Tsilidis, Konstantinos
name: Kyrgiou, Maria
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy

description: Additional file 3: Table S1B. Evaluation of heterogeneity, small study effects, excess significance bias and credibility ceilings in the 47 meta-analyses investigating the association of diabetes with gynaecological and obstetric morbidity– cohort studies only.
Molecular detection of three intestinal cestode species (Raillietina echinobothrida, R. tetragona, R. cesticillus) from poultry in Thailand
Creators: name: Panich, Wasin
name: Chontananarth, Thapana
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Cestodes belonging to the genus Raillietina are a major veterinary health problem affecting the poultry industry, particularly chickens (Gallus gallus domesticus) and ducks (Anas playtrhynchos domesticus). The traditional method for accurately detecting this cestode based on their morphological characteristics is rather difficult due to the large number of morphological similarities. Consequently, this study aimed to develop specific primers for R. echinobothrida, R. tetragona, and R. cesticillus detection that could be used to indicate epidemic areas for protection and infection control. Specific primers were manually designed based on the internal transcribed spacer 2 region and validated, establishing the optimal temperature, final concentration in PCR mixture, specificity, and sensitivity of each primer set. The results showed that the primers amplify specific species without cross-amplifying other parasites and hosts. The PCR products were about 473, 352, and 397 bp long for R. echinobothrida, R. tetragona, and R. cesticillus, respectively. The sensitivity test demonstrated that R. echinobothrida and R. cesticillus-specific primers detect a minimum of 5×10−2 ng DNA, while R. tetragona-specific primers detect a minimum of 0.5 ng genomic DNA. The specific primers successfully developed in this study might be useful for detecting cysticercoids in intermediate hosts or adult stages in poultry for epidemiological surveys, management and control of infection. This study established specific primers for Raillietina species detection.The ITS2 region is an effective molecular marker for Raillietina identification. This study established specific primers for Raillietina species detection. The ITS2 region is an effective molecular marker for Raillietina identification.
Quantum Breathing of an Impurity in a One-dimensional Bath of Interacting Bosons
Creators: name: Peotta, Sebastiano
name: Rossini, Davide
name: Polini, Marco
name: Minardi, Francesco
name: Fazio, Rosario
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: By means of time-dependent density-matrix renormalization-group (TDMRG) we are able to follow the real-time dynamics of a single impurity embedded in a one-dimensional bath of interacting bosons. We focus on the impurity breathing mode, which is found to be well-described by a single oscillation frequency and a damping rate. If the impurity is very weakly coupled to the bath, a Luttinger-liquid description is valid and the impurity suffers an Abraham-Lorentz radiation-reaction friction. For a large portion of the explored parameter space, the TDMRG results fall well beyond the Luttinger-liquid paradigm.
description: 10 pages, 7 figures, main text and supplementary material merged in a single PRB style document
Permafrost, fire, and the regeneration of white spruce at arctic treeline near Inuvik, Northwest Territories, Canada
Creators: name: Greene, David F. (David Freeman), 1951-
Publisher: name: University of Calgary
Year: 1983
Subjects: subject: QK 494.5 P66 G72 1986
subject: White spruce
subject: Plants, Effect of cold on
subject: Trees - Fire damage
subject: Regeneration (Botany)

description: Bibliography: p. 126-138.
Additional file 1 of Addressing disparities in Pre-exposure Prophylaxis (PrEP) access: implementing a community-centered mobile PrEP program in South Florida
Creators: name: Butts, Stefani A.
name: Young, BreAnne
name: Blackmon, Jakisha
name: Doblecki-Lewis, Susanne
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 1
Frozen shuffle update for an asymmetric exclusion process with open boundary conditions
Creators: name: Appert-Rolland, C.
name: Cividini, J.
name: Hilhorst, H. J.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences

description: We introduce a new update algorithm for exclusion processes, more suitable for the modeling of pedestrian traffic. Pedestrians are modeled as hard-core particles hopping on a discrete lattice, and are updated in a fixed order, determined by a phase attached to each pedestrian. While the case of periodic boundary conditions was studied in a companion paper, we consider here the case of open boundary conditions. The full phase diagram is predicted analytically and exhibits a transition between a free flow phase and a jammed phase. The density profile is predicted in the frame of a domain wall theory, and compared to Monte Carlo simulations, in particular in the vicinity of the transition.
description: 22 pages, 8 Figures
Off-line data processing and analysis for the GERDA experiment
Creators: name: Agostini, M.
name: Pandola, L.
name: Zavarise, P.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Experiment (nucl-ex)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: GERDA is an experiment designed to look for the neutrinoless double beta decay of Ge-76. The experiment uses an array of high-purity germanium detectors, enriched in Ge-76, directly immersed in liquid argon. GERDA is presently operating eight enriched coaxial detectors (approximately 15 kg of Ge-76) and about 30 new custom-made enriched BEGe detectors will be deployed in the next phase (additional 20 kg of Ge-76). The paper describes the GERDA off-line analysis of the high-purity germanium detector data. Firstly we present the signal processing flow, focusing on the digital filters and on the algorithms used. Secondly we discuss the rejection of non-physical events and the data quality monitoring. The analysis is performed completely with the GERDA software framework (GELATIO), designed to support a multi-channel processing and to perform a modular analysis of digital signals.
description: 7 pages, 7 figures, ACAT 2011 proceeding
Additional file 4 of Diabetes and anti-diabetic interventions and the risk of gynaecological and obstetric morbidity: an umbrella review of the literature
Creators: name: Semertzidou, Anita
name: Grout-Smith, Harriet
name: Kalliala, Ilkka
name: Garg, Akanksha
name: Terzidou, Vasso
name: Marchesi, Julian
name: MacIntyre, David
name: Bennett, Phillip
name: Tsilidis, Konstantinos
name: Kyrgiou, Maria
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy

description: Additional file 4: Table S2. AMSTAR 2 methodological quality assessment for observational systematic reviews investigating the association of diabetes and anti-diabetic interventions with gynaecological and obstetric morbidity- cohorts only.