cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Kenmotsu Manifolds Admitting a Non-Symmetric Non-Metric Connection
Creators: name: Chaubey, S. K.
name: Yadav, S. K.
name: Garvandha, Mahesh
Publisher: name: arXiv
Year: 2019
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics

description: The aim of the present paper is to study the properties of Kenmotsu manifolds equipped with a non-symmetric non-metric connection. We also establish some curvature properties of Kenmotsu manifolds. It is proved that a Kenmotsu manifold endowed with a non-symmetric non-metric is irregular.
description: 7
Weak localization of the open kicked rotator
Creators: name: Tworzydlo, J.
name: Tajic, A.
name: Beenakker, C. W. J.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We present a numerical calculation of the weak localization peak in the magnetoconductance for a stroboscopic model of a chaotic quantum dot. The magnitude of the peak is close to the universal prediction of random-matrix theory. The width depends on the classical dynamics, but this dependence can be accounted for by a single parameter: the level curvature around zero magnetic field of the closed system.
description: 8 pages, 8 eps figures
Electromagnetic radiation from the pre-equilibrium/pre-hydro stage of the quark-gluon plasma
Creators: name: Churchill, Jessica
name: Yan, Li
name: Jeon, Sangyong
name: Gale, Charles
Publisher: name: arXiv
Year: 2020
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Photons produced in the pre-equilibrium/pre-hydro stage of the quark-gluon plasma produced in relativistic heavy-ion collisions were computed using parton distribution functions obtained from solutions of the Boltzmann equation. The effect of the initial gluon momentum anisotropy $ξ$ and the dependence on the saturation momentum $Q_s$ was investigated. We see that small $Q_s$ results in a photon yield enhancement, whereas a larger $Q_s$ results in a pre-equilibrium photon suppression, owing to the strict constraint of matching to experimental energy density.
description: 4 pages, 2 figures, presented at Quark Matter 2019
The X-ray spectrum of the black hole candidate GX339-4 in a low state
Creators: name: Corongiu, A.
name: Chiappetti, L.
name: Haardt, F.
name: Treves, A.
name: Colpi, M.
name: Belloni, T.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We report on four observations of the black hole candidate GX 339-4 collected in the spectral range 0.4-140 keV with the BeppoSAX satellite during 1997. All our spectra are typical of a black hole candidate in its low-hard state, i.e. are dominated by the hard tail of the emission from the corona. Although the direct emission from the accretion disk in the soft X-ray range is weak, spectra are well described only with models that take into consideration the Compton reflection of hard X-rays from the corona onto the surface of an accretion disk of non negligible extent.
description: 6 pages, LaTeX, 4 pictures
Fast, In Vivo Model for Drug-Response Prediction in Patients with B-Cell Precursor Acute Lymphoblastic Leukemia
Creators: name: Gauert, Anton
name: Olk, Nadine
name: Pimentel-Gutiérrez, Helia
name: Astrahantseff, Kathy
name: Jensen, Lasse D.
name: Cao, Yihai
name: Eggert, Angelika
name: Eckert, Cornelia
name: Heeren-Hagemann, Anja Irene
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: pediatric cancer
subject: personalized therapy
subject: BCP-ALL
subject: zebrafish
subject: patient-derived xenograft
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Only half of patients with relapsed B-cell precursor (BCP) acute lymphoblastic leukemia (ALL) currently survive with standard treatment protocols. Predicting individual patient responses to defined drugs prior to application would help therapy stratification and could improve survival. With the purpose to aid personalized targeted treatment approaches, we developed a human-zebrafish xenograft (ALL-ZeFiX) assay to predict drug response in a patient in 5 days. Leukemia blast cells were pericardially engrafted into transiently immunosuppressed Danio rerio embryos, and engrafted embryos treated for the test case, venetoclax, before single-cell dissolution for quantitative whole blast cell analysis. Bone marrow blasts from patients with newly diagnosed or relapsed BCP-ALL were successfully expanded in 60% of transplants in immunosuppressed zebrafish embryos. The response of BCP-ALL cell lines to venetoclax in ALL-ZeFiX assays mirrored responses in 2D cultures. Venetoclax produced varied responses in patient-derived BCP-ALL grafts, including two results mirroring treatment responses in two refractory BCP-ALL patients treated with venetoclax. Here we demonstrate proof-of-concept for our 5-day ALL-ZeFiX assay with primary patient blasts and the test case, venetoclax, which after expanded testing for further targeted drugs could support personalized treatment decisions within the clinical time window for decision-making.
The Acquisition of Attitudes and Professional Skills for Global Citizenship throughSecond Language Learning at a Bilingual Education Provider in Thailand
Creators: name: Unyime Francis Bassey
Publisher: name: Faculty of Education, Rangsit University
Year: 2020
Subjects: Attitude for Global Citizenship, Professional Skills for Global Citizenship, Bilingual Students, Second Language Learning, Bilingual Education Provider

description: Rangsit Journal of Educational Studies, 7, 2, 62-76
Selenium and Copper as Biomarkers for Pulmonary Arterial Hypertension in Systemic Sclerosis
Creators: name: Sun, Qian
name: Hackler, Julian
name: Hilger, Julia
name: Gluschke, Hans
name: Muric, Aldina
name: Simmons, Szandor
name: Schomburg, Lutz
name: Siegert, Elise
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: trace element
subject: inflammation
subject: selenoprotein P
subject: ceruloplasmin
subject: glutathione peroxidase
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Circulating selenoprotein P (SELENOP) constitutes an established biomarker of Se status. SELENOP concentrations are reduced in inflammation and severe disease. Recently, elevated SELENOP levels have been suggested as diagnostic marker and therapeutic target in pulmonary arterial hypertension (PAH). We decided to re-evaluate this hypothesis. A group of healthy controls (n = 30) was compared with patients suffering from systemic sclerosis (SSc, n = 66), one third with SSc-related PAH. Serum was analysed for trace elements and protein biomarkers, namely SELENOP, glutathione peroxidase 3 (GPx3) and ceruloplasmin (CP). Compared to controls, patients with SSc-related PAH displayed reduced serum Se (91 ± 2 vs. 68 ± 2 µg/L) and SELENOP concentrations (3.7 ± 0.8 vs. 2.7 ± 0.9 mg/L), along with lower GPx3 activity (278 ± 40 vs. 231 ± 54 U/L). All three biomarkers of Se status were particularly low in patients with skin involvement. Serum Cu was not different between the groups, but patients with SSc-related PAH showed elevated ratios of Cu/Se and CP/SELENOP as compared to controls. Our data indicate that patients with SSc-related PAH are characterized by reduced Se status in combination with elevated CP, in line with other inflammatory diseases. Further analyses are needed to verify the diagnostic value of these TE-related biomarkers in PAH.
Teaching computers to fold proteins
Creators: name: Winther, Ole
name: Krogh, Anders
Publisher: name: arXiv
Year: 2003
Subjects: subject: Condensed Matter (cond-mat)
subject: Biomolecules (q-bio.BM)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: A new general algorithm for optimization of potential functions for protein folding is introduced. It is based upon gradient optimization of the thermodynamic stability of native folds of a training set of proteins with known structure. The iterative update rule contains two thermodynamic averages which are estimated by (generalized ensemble) Monte Carlo. We test the learning algorithm on a Lennard-Jones (LJ) force field with a torsional angle degrees-of-freedom and a single-atom side-chain. In a test with 24 peptides of known structure, none folded correctly with the initial potential functions, but two-thirds came within 3Å to their native fold after optimizing the potential functions.
description: 4 pages, 3 figures
Pseudosinella mauli Stomp 1972
Creators: name: Thibaud, Jean-Marc
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Entomobryomorpha
Entomobryidae
Pseudosinella
Pseudosinella mauli

description: Pseudosinella mauli Stomp, 1972
Pseudosinella mauli Stomp, 1972: 279.
DISTRIBUTION. — Essonne. Forêtde Sénart (Stomp 1977; Ponge 1980, 1993). — Brunoy (Chauvat & Ponge 2002).
Loiret. Forêtd’Orléans (Ponge etal. 1993).
Nièvre. Parcrégionaldu Morvan (Ponge etal. 2003).
TAXONOMIE. — Stomp 1977 (redescription).
ÉCOLOGIE. — Stomp 1977; Ponge 1980, 1993; Ponge etal. 1993 (écologie expérimentale, litière), 2003 (bioindicateur); Chauvat & Ponge 2002 (métaux lourds).
description: Published as part of Thibaud, Jean-Marc, 2017, Catalogue des collemboles de France, pp. 297-436 in Zoosystema 39 (3) on page 391, DOI: 10.5252/z2017n3a1, http://zenodo.org/record/5496272
TraMoS V. Updated ephemeris and multi-epoch monitoring of the hot Jupiters WASP-18Ab, WASP-19b, and WASP-77Ab
Creators: name: Cortes-Zuleta, Pia
name: Rojo, Patricio
name: Wang, Songhu
name: Hinse, Tobias C.
name: Hoyer, Sergio
name: Sanhueza, Bastian
name: Correa-Amaro, Patricio
name: Albornoz, Julio
Publisher: name: arXiv
Year: 2020
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present 22 new transit observations of the exoplanets WASP-18Ab, WASP-19b, and WASP-77Ab, from the Transit Monitoring in the South (TraMoS) project. We simultaneously model our newly collected transit light curves with archival photometry and radial velocity data, to obtain refined physical and orbital parameters. We include TESS light curves of the three exoplanets to perform an extended analysis of the variations in their transit mid-time (TTV) and to refine their planetary orbital ephemeris. We did not find significant $\rm TTV_{RMS}$ variations larger than 47, 65, and 86 seconds for WASP-18Ab, WASP-19b, and WASP-77Ab, respectively. Dynamical simulations were carried out to constrain the masses of a possible perturber. The observed RMS could be produced by a perturber body with an upper limit mass of 9, 2.5, 11 and $4~M_{\oplus}$ in 1:2, 1:3, 2:1, and 3:1 resonances in the WASP-18Ab system. In the case of WASP-19b, companions with masses up to 0.26, 0.65, 1 and $2.8~M_{\oplus}$, in 1:2, 2:1, 3:1, and 5:3 resonances, produce the RMS. And for the WASP-77Ab system, a planet with mass between $1.5-9~M_{\oplus}$ in 1:2, 1:3, 2:1, 2:3, 3:1, 3:5, 5:3 resonances. Comparing our results with RV variations, we discard massive companions with $350~M_{\oplus}$ in 17:5 resonance for WASP-18Ab, $95~M_{\oplus}$ in 4:1 resonance for WASP-19b and $105~M_{\oplus}$ in 5:2 resonance for WASP-77Ab. Finally, using a Lomb-Scargle period search we find no evidence of a periodic trend on our TTV data for the three exoplanets.
description: 20 pages, 8 figures. Accepted for publication in A&A
Cheumatopsyche varia
Creators: name: Oláh, János
name: Johanson, Kjell Arne
name: Barnard, Peter C.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Hydropsychidae
Cheumatopsyche
Cheumatopsyche varia

description: Cheumatopsyche varia (Kimmins, 1955)
 Hydropsychodes varia Kimmins, 1955: 391.
 Cheumatopsyche varia (Kimmins, 1955); Kimmins 1963: 130.
 Type locality: Malaysia (Sarawak).
 New Records. MALAYSIA: Borneo: Sabah, Sipitang, Mendolong Nersery, 2.v.1988, light leg. [S. Adebratt] — 14 males (NRM, alcohol), 2 males (OPC, alcohol).
description: Published as part of Oláh, János, Johanson, Kjell Arne & Barnard, Peter C., 2008, Revision of the Oriental and Afrotropical species of Cheumatopsyche Wallengren (Hydropsychidae, Trichoptera), pp. 1-171 in Zootaxa 1738 on page 92
Multi-Parameter Analysis of Biobanked Human Bone Marrow Stromal Cells Shows Little Influence for Donor Age and Mild Comorbidities on Phenotypic and Functional Properties
Creators: name: Andrzejewska, Anastazja
name: Catar, Rusan
name: Schoon, Janosch
name: Qazi, Taimoor Hasan
name: Sass, Frauke Andrea
name: Jacobi, Dorit
name: Blankenstein, Antje
name: Reinke, Simon
name: Krüger, David
name: Streitz, Mathias
name: Schlickeiser, Stephan
name: Richter, Sarina
name: Souidi, Naima
name: Beez, Christien
name: Kamhieh-Milz, Julian
name: Krüger, Ulrike
name: Zemojtel, Tomasz
name: Jürchott, Karsten
name: Strunk, Dirk
name: Reinke, Petra
name: Duda, Georg
name: Moll, Guido
name: Geissler, Sven
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: bone marrow stromal cell
subject: cellular therapy
subject: comorbidity
subject: in vitro potency assay
subject: in vivo and in vitro aging
subject: mesenchymal stromal cell
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Heterogeneous populations of human bone marrow-derived stromal cells (BMSC) are among the most frequently tested cellular therapeutics for treating degenerative and immune disorders, which occur predominantly in the aging population. Currently, it is unclear whether advanced donor age and commonly associated comorbidities affect the properties of ex vivo-expanded BMSCs. Thus, we stratified cells from adult and elderly donors from our biobank (n = 10 and n = 13, mean age 38 and 72 years, respectively) and compared their phenotypic and functional performance, using multiple assays typically employed as minimal criteria for defining multipotent mesenchymal stromal cells (MSCs). We found that BMSCs from both cohorts meet the standard criteria for MSC, exhibiting similar morphology, growth kinetics, gene expression profiles, and pro-angiogenic and immunosuppressive potential and the capacity to differentiate toward adipogenic, chondrogenic, and osteogenic lineages. We found no substantial differences between cells from the adult and elderly cohorts. As positive controls, we studied the impact of in vitro aging and inflammatory cytokine stimulation. Both conditions clearly affected the cellular properties, independent of donor age. We conclude that in vitro aging rather than in vivo donor aging influences BMSC characteristics.
Predicting MMSE Score from Finger-Tapping Measurement
Creators: name: Ma, Jian
Publisher: name: arXiv
Year: 2020
Subjects: subject: Quantitative Methods (q-bio.QM)
subject: Machine Learning (cs.LG)
subject: Applications (stat.AP)
subject: FOS: Biological sciences
subject: FOS: Computer and information sciences

description: Dementia is a leading cause of diseases for the elderly. Early diagnosis is very important for the elderly living with dementias. In this paper, we propose a method for dementia diagnosis by predicting MMSE score from finger-tapping measurement with machine learning pipeline. Based on measurement of finger tapping movement, the pipeline is first to select finger-tapping attributes with copula entropy and then to predict MMSE score from the selected attributes with predictive models. Experiments on real world data show that the predictive models such developed present good prediction performance. As a byproduct, the associations between certain finger-tapping attributes ('Number of taps', 'Average of intervals', and 'Frequency of taps' of both hands of bimanual in-phase task) and MMSE score are discovered with copula entropy, which may be interpreted as the biological relationship between cognitive ability and motor ability and therefore makes the predictive models explainable. The selected finger-tapping attributes can be considered as dementia biomarkers.
description: 11 pages, 4 figures, 2 tables
Quantum phase transitions in two-dimensional systems
Creators: name: Shangina, E. L.
name: Dolgopolov, V. T.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Experimental data on quantum phase transitions in two-dimensional systems (superconductor-insulator, metal-insulator, and transitions under conditions of integer quantum Hall effect) are critically analyzed.
description: 13 pages, 16 figures
Maternal but Not Paternal High-Fat Diet (HFD) Exposure at Conception Predisposes for 'Diabesity' in Offspring Generations
Creators: name: Schellong, Karen
name: Melchior, Kerstin
name: Ziska, Thomas
name: Rancourt, Rebecca C.
name: Henrich, Wolfgang
name: Plagemann, Andreas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: developmental/perinatal programming
subject: maternal and paternal overnutrition
subject: high-fat diet
subject: intergenerational effects
subject: obesity
subject: diabetes
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: While environmental epigenetics mainly focuses on xenobiotic endocrine disruptors, dietary composition might be one of the most important environmental exposures for epigenetic modifications, perhaps even for offspring generations. We performed a large-scale rat study on key phenotypic consequences from parental (F0) high-caloric, high-fat diet (HFD) food intake, precisely and specifically at mating/conception, focusing on 'diabesity' risk in first- (F1) and second- (F2) generation offspring of both sexes. F0 rats (maternal or paternal, respectively) received HFD overfeeding, starting six weeks prior to mating with normally fed control rats. The maternal side F1 offspring of both sexes developed a 'diabesity' predisposition throughout life (obesity, hyperleptinemia, hyperglycemia, insulin resistance), while no respective alterations occurred in the paternal side F1 offspring, neither in males nor in females. Mating the maternal side F1 females with control males under standard feeding conditions led, again, to a 'diabesity' predisposition in the F2 generation, which, however, was less pronounced than in the F1 generation. Our observations speak in favor of the critical impact of maternal but not paternal metabolism around the time frame of reproduction for offspring metabolic health over generations. Such fundamental phenotypic observations should be carefully considered in front of detailed molecular epigenetic approaches on eventual mechanisms.
Pseudosinella melatensis Gisin & Gama 1969
Creators: name: Thibaud, Jean-Marc
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Entomobryomorpha
Entomobryidae
Pseudosinella
Pseudosinella melatensis

description: Pseudosinella melatensis Gisin & Gama, 1969
Pseudosinella melatensis Gisin & Gama, 1969a: 163.
DISTRIBUTION. — Hautes-Pyrénées. Grotte des Aigues de Melat prèsde Saint-Pé-de-Bigorre (Gisin & Gama 1969a; Gama 1976).
description: Published as part of Thibaud, Jean-Marc, 2017, Catalogue des collemboles de France, pp. 297-436 in Zoosystema 39 (3) on page 391, DOI: 10.5252/z2017n3a1, http://zenodo.org/record/5496272
The fundamental group of quotients of products of some topological spaces by a finite group -- A generalization of a Theorem of Bauer-Catanese-Grunewald-Pignatelli
Creators: name: Aguilar, Rodolfo
Publisher: name: arXiv
Year: 2020
Subjects: subject: Algebraic Geometry (math.AG)
subject: Group Theory (math.GR)
subject: FOS: Mathematics

description: We provide a description of the fundamental group of the quotient of a product of topological spaces $X_i$, each admitting a universal cover, by a finite group $G$, provided that there is only a finite number of path-connected components in $X_i^g$ for every $g\in G$. This generalizes previous work of Bauer-Catanese-Grunewald-Pignatelli and Dedieu-Perroni.
Immunoglobulin G Subclass-Specific Glycosylation Changes in Primary Epithelial Ovarian Cancer
Creators: name: Wieczorek, Marta
name: Braicu, Elena Ioana
name: Oliveira-Ferrer, Leticia
name: Sehouli, Jahid
name: Blanchard, Véronique
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: IgG subclasses
subject: N-glycopeptides
subject: glycosylation
subject: ovarian cancer
subject: MALDI-TOF-MS
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Epithelial ovarian cancer (EOC) was previously shown to be associated with glycosylation changes of total serum and total IgG proteins. However, as a majority of previous studies analyzed released glycan profiles, still little is known about IgG subclass-specific alterations in ovarian cancer. Hence, in this study, we investigated EOC-related glycosylation changes of the three most abundant IgG subclasses, namely, IgG1, IgG2 and IgG3 isolated from sera of 87 EOC patients and 74 age-matched healthy controls. In order to separate IgG2 and IgG3, we performed a two-step affinity purification employing Protein A and Protein G Sepharose. After tryptic digestion, IgG glycopeptides were enriched and measured by MALDI-TOF-MS. Finally, EOC-related glycosylation changes were monitored at the level of total agalactosylation, monogalactosylation, digalactosylation, sialylation, bisection and fucosylation, which were calculated separately for each IgG subclass. Interestingly, aside from an EOC-related increase in agalactosylation/decrease in monogalactosylation and digalactosylation observed in all IgG subclasses, some subclass-specific trends were detected. Glycosylation of IgG1 was found to be most strongly affected in EOC, as it exhibited the highest number of significant differences between healthy controls and EOC patients. Specifically, IgG1 was the only subclass that showed a significant decrease in sialylation and a significant increase in fucosylation in EOC patients. Interestingly, IgG2 and IgG3 that were often investigated collectively in previous studies, were found to have distinct glycosylation patterns. IgG3 displayed stronger EOC-related increase in agalactosylation/decrease in digalactosylation and was characterized by notably higher sialylation, which consequently decreased in EOC patients. In conclusion, our study indicates that IgG subclasses exhibit subtly distinct glycosylation patterns of EOC-related alterations and that IgG1 and IgG3 agalactosylation show the strongest association with CA125, the routine diagnostic marker. Additionally, our results show that simultaneous analyses of IgG2 and IgG3 might lead to wrong conclusions as these two subclasses exhibit noticeably different glycosylation phenotypes.
Seizure Prediction Using Bidirectional LSTM
Creators: name: Ali, Hazrat
name: Karim, Feroz
name: Qureshi, Junaid Javed
name: Abuassba, Adnan Omer
name: Bulbul, Mohammad Farhad
Publisher: name: arXiv
Year: 2019
Subjects: subject: Machine Learning (cs.LG)
subject: Signal Processing (eess.SP)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Approximately, 50 million people in the world are affected by epilepsy. For patients, the anti-epileptic drugs are not always useful and these drugs may have undesired side effects on a patient's health. If the seizure is predicted the patients will have enough time to take preventive measures. The purpose of this work is to investigate the application of bidirectional LSTM for seizure prediction. In this paper, we trained EEG data from canines on a double Bidirectional LSTM layer followed by a fully connected layer. The data was provided in the form of a Kaggle competition by American Epilepsy Society. The main task was to classify the interictal and preictal EEG clips. Using this model, we obtained an AUC of 0.84 on the test dataset. Which shows that our classifier's performance is above chance level on unseen data. The comparison with the previous work shows that the use of bidirectional LSTM networks can achieve significantly better results than SVM and GRU networks.
description: CyberDI 2019, Cyberspace Data and Intelligence, and Cyber-Living, Syndrome, and Health pp 349-356
Radiosurgery and fractionated stereotactic body radiotherapy for patients with lung oligometastases
Creators: name: Kalinauskaite, Goda G.
name: Tinhofer, Ingeborg I.
name: Kufeld, Markus M.
name: Kluge, Anne A.
name: Grün, Arne A.
name: Budach, Volker V.
name: Senger, Carolin C.
name: Stromberger, Carmen C.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Oligometastases
subject: SBRT
subject: Radiosurgery
subject: Lung metastases
subject: CyberKnife
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Patients with oligometastatic disease can potentially be cured by using an ablative therapy for all active lesions. Stereotactic body radiotherapy (SBRT) is a non-invasive treatment option that lately proved to be as effective and safe as surgery in treating lung metastases (LM). However, it is not clear which patients benefit most and what are the most suitable fractionation regimens. The aim of this study was to analyze treatment outcomes after single fraction radiosurgery (SFRS) and fractionated SBRT (fSBRT) in patients with lung oligometastases and identify prognostic clinical features for better survival outcomes. Methods: Fifty-two patients with 94 LM treated with SFRS or fSBRT between 2010 and 2016 were analyzed. The characteristics of primary tumor, LM, treatment, toxicity profiles and outcomes were assessed. Kaplan-Meier and Cox regression analyses were used for estimation of local control (LC), overall survival (OS) and progression-free survival. Results: Ninety-four LM in 52 patients were treated using SFRS/fSBRT with a median of 2 lesions per patient (range: 1-5). The median planning target volume (PTV)-encompassing dose for SFRS was 24 Gy (range: 17-26) compared to 45 Gy (range: 20-60) in 2-12 fractions with fSBRT. The median follow-up time was 21 months (range: 3-68). LC rates at 1 and 2 years for SFSR vs. fSBRT were 89 and 83% vs. 75 and 59%, respectively (p = 0.026). LM treated with SFSR were significantly smaller (p = 0.001). The 1 and 2-year OS rates for all patients were 84 and 71%, respectively. In univariate analysis treatment with SFRS, an interval of ≥12 months between diagnosis of LM and treatment, non-colorectal cancer histology and BED < 100 Gy were significantly associated with better LC. However, none of these parameters remained significant in the multivariate Cox regression model. OS was significantly better in patients with negative lymph nodes (N0), Karnofsky performance status (KPS) > 70% and time to first metastasis ≥12 months. There was no grade 3 acute or late toxicity. Conclusions: Longer time to first metastasis, good KPS and N0 predicted better OS. Good LC and low toxicity rates were achieved after short SBRT schedules.
Late B-type stars and their candidate companions resolved with Chandra
Creators: name: Stelzer, B.
name: Huelamo, N.
name: Hubrig, S.
name: Zinnecker, H.
name: Micela, G.
name: ;
name: Palermo, - OA
name: Chile, - ESO
name: Potsdam, - AI
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present the first results from a series of Chandra observations carried out with the aim to examine the origin of X-ray emission in main-sequence late B-type stars. We use high spatial resolution X-ray observations to enlighten the prevalent speculation that previously unknown late-type or low-mass companion stars are the sites of the X-ray emission, instead of the B-type primaries. Here we present the results for HD1685, HD113703, HD123445, HD133880, and HD169978. Adaptive optics observations have recently revealed at least one faint object near each of these B-type stars (at separation of 1-6"). Four of the new infrared objects show infrared colors and magnitudes typical for low-mass pre-main sequence stars, and are likely true companions to the 10-50 Myr old B-type stars. These multiple systems are now resolved for the first time in X-ray light.
description: 12 pages, accepted for publication in A&A
Cheumatopsyche contexta
Creators: name: Oláh, János
name: Johanson, Kjell Arne
name: Barnard, Peter C.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Hydropsychidae
Cheumatopsyche
Cheumatopsyche contexta

description: Cheumatopsyche contexta (Ulmer, 1951)
 Hydropsychodes contexta Ulmer, 1951: 23.
 Cheumatopsyche contexta (Ulmer, 1951); Kimmins 1963: 130.
 Type locality: Indonesia (Java).
description: Published as part of Oláh, János, Johanson, Kjell Arne & Barnard, Peter C., 2008, Revision of the Oriental and Afrotropical species of Cheumatopsyche Wallengren (Hydropsychidae, Trichoptera), pp. 1-171 in Zootaxa 1738 on page 94
Pseudosinella mucronata Gouze & Deharveng 1986
Creators: name: Thibaud, Jean-Marc
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Entomobryomorpha
Entomobryidae
Pseudosinella
Pseudosinella mucronata

description: Pseudosinella mucronata Gouze & Deharveng, 1986 **
Pseudosinella mucronata Gouze & Deharveng, 1986: 66.
DISTRIBUTION. — Var. Aven du Micoulet à Aiguine et grotte de Moustiers-Sainte-Marie (Gouze & Deharveng 1986).
description: Published as part of Thibaud, Jean-Marc, 2017, Catalogue des collemboles de France, pp. 297-436 in Zoosystema 39 (3) on page 392, DOI: 10.5252/z2017n3a1, http://zenodo.org/record/5496272
Using natural language processing to extract health-related causality from Twitter messages
Creators: name: Doan, Son
name: Yang, Elly W
name: Tilak, Sameer
name: Torii, Manabu
Publisher: name: arXiv
Year: 2019
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences

description: Twitter messages (tweets) contain various types of information, which include health-related information. Analysis of health-related tweets would help us understand health conditions and concerns encountered in our daily life. In this work, we evaluated an approach to extracting causal relations from tweets using natural language processing (NLP) techniques. We focused on three health-related topics: stress", "insomnia", and "headache". We proposed a set of lexico-syntactic patterns based on dependency parser outputs to extract causal information. A large dataset consisting of 24 million tweets were used. The results show that our approach achieved an average precision between 74.59% and 92.27%. Analysis of extracted relations revealed interesting findings about health-related in Twitter.
description: 5 pages
Directed acyclic graphs and causal thinking in clinical risk prediction modeling
Creators: name: Piccininni, Marco
name: Konigorski, Stefan
name: Rohmann, Jessica Lee
name: Kurth, Tobias
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Causality
subject: Clinical risk prediction
subject: Prediction models
subject: Markov blanket
subject: Directed acyclic graph
subject: Transportability
subject: Predictor selection
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: In epidemiology, causal inference and prediction modeling methodologies have been historically distinct. Directed Acyclic Graphs (DAGs) are used to model a priori causal assumptions and inform variable selection strategies for causal questions. Although tools originally designed for prediction are finding applications in causal inference, the counterpart has remained largely unexplored. The aim of this theoretical and simulation-based study is to assess the potential benefit of using DAGs in clinical risk prediction modeling. Methods: We explore how incorporating knowledge about the underlying causal structure can provide insights about the transportability of diagnostic clinical risk prediction models to different settings. We further probe whether causal knowledge can be used to improve predictor selection in clinical risk prediction models. Results: A single-predictor model in the causal direction is likely to have better transportability than one in the anticausal direction in some scenarios. We empirically show that the Markov Blanket, the set of variables including the parents, children, and parents of the children of the outcome node in a DAG, is the optimal set of predictors for that outcome. Conclusions: Our findings provide a theoretical basis for the intuition that a diagnostic clinical risk prediction model including causes as predictors is likely to be more transportable. Furthermore, using DAGs to identify Markov Blanket variables may be a useful, efficient strategy to select predictors in clinical risk prediction models if strong knowledge of the underlying causal structure exists or can be learned.
Surprises in Bose-Einstein correlations
Creators: name: Zalewski, Kacper
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Four experimental results, which seem to contradict the established ideas about the Bose-Einstein correlations in multiple particle production processes, are briefly presented and dicussed.
description: LateX, 8 pages, no figures, Report at QCD'03 Montpellier, July 2003
Cheumatopsyche cornix Malicky 1997
Creators: name: Oláh, János
name: Johanson, Kjell Arne
name: Barnard, Peter C.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Hydropsychidae
Cheumatopsyche
Cheumatopsyche cornix

description: Cheumatopsyche cornix Malicky, 1997
 Cheumatopsyche cornix Malicky, 1997: 1031.
 Type locality: Malaysia (Perak).
 New records: MALAYSIA: Perak, Temengor Lake, ix–x.1993, light [G. S. Robinson] — 12 males (BMNH, in alcohol).
 Remarks: All 12 males have four stout spines on the apicoventral lobes of segment IX, but in the holotype only a single spine was described. However, all other characters seem identical.
description: Published as part of Oláh, János, Johanson, Kjell Arne & Barnard, Peter C., 2008, Revision of the Oriental and Afrotropical species of Cheumatopsyche Wallengren (Hydropsychidae, Trichoptera), pp. 1-171 in Zootaxa 1738 on page 132
Pseudosinella ocellata
Creators: name: Thibaud, Jean-Marc
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Entomobryomorpha
Entomobryidae
Pseudosinella
Pseudosinella ocellata

description: Pseudosinella ocellata (Absolon, 1901)
Sirodes ocellatus Absolon, 1901b: 378.
Pseudosinella ocellata – Bonet 1931: 384.
DISTRIBUTION. — Lot. Grouffre de Padirac (Absolon 1901b).
description: Published as part of Thibaud, Jean-Marc, 2017, Catalogue des collemboles de France, pp. 297-436 in Zoosystema 39 (3) on page 392, DOI: 10.5252/z2017n3a1, http://zenodo.org/record/5496272
New Constraint of Clustering for AMD and Its Application to the Study of $2α$-$^{12}$C Structure of $^{20}$Ne
Creators: name: Taniguchi, Yasutaka
name: Kimura, Masaaki
name: Horiuchi, Hisashi
Publisher: name: arXiv
Year: 2004
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: A new constraint of clustering for the AMD calculation is proposed. This new constraint gives us large improvement in studying the cluster structure by AMD which sometimes meets difficulty in giving rise to some specific cluster configurations. The usefulness of this new constraint is verified by applying it to the the study of the third $K^π= 0^+$ band of $^{20}$Ne which has been discussed to have $2α$-$^{12}$C structure. This band has not been easy even to construct by AMD. We see that the AMD+GCM calculation by the use of the new constraint gives rise to the third $K^π= 0^+$ band which contains the $2α$-$^{12}$C structure as an important component.
description: 13 pages, 4 figures
Ill-posedness of the mean-field dynamo equations with a linear electromotive force
Creators: name: Rubio, Marcelo E.
name: Stasyszyn, Federico A.
Publisher: name: arXiv
Year: 2020
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We show that the initial-value problem for the non-relativistic magnetic dynamo equation turns out to be ill-posed when the electromotive force depends linearly on the magnetic field. This result implies that the increasing of magnetic energy does not necessarily come from physical amplification mechanisms, since certain magnetic modes could arbitrarily grow as wave-frequency increases, despite any dynamo-like process. Thus, up to this order, the theory is not suitable for astrophysical simulations. We then study the case when electromotive forces are linear in magnetic field derivatives, showing that the resulting system has a well-posed problem. Finally, we apply the well-posed theory to the force-free regime, for which we find bounds for the corresponding magnetic energy analyzing the evolution of the magnetic helicity.
description: 28 pages, no figures, accepted for publication in Physica D: Nonlinear phenomena
Information decomposition of symbolic sequences
Creators: name: Korotkov, Eugene V.
name: Korotkova, Maria A.
name: Kudryashov, Nikolai A.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Spectral Theory (math.SP)
subject: Quantitative Biology (q-bio)
subject: FOS: Mathematics
subject: FOS: Biological sciences
subject: 40-xx; 94Axx; 42-xx

description: We developed a non-parametric method of Information Decomposition (ID) of a content of any symbolical sequence. The method is based on the calculation of Shannon mutual information between analyzed and artificial symbolical sequences, and allows the revealing of latent periodicity in any symbolical sequence. We show the stability of the ID method in the case of a large number of random letter changes in an analyzed symbolic sequence. We demonstrate the possibilities of the method, analyzing both poems, and DNA and protein sequences. In DNA and protein sequences we show the existence of many DNA and amino acid sequences with different types and lengths of latent periodicity. The possible origin of latent periodicity for different symbolical sequences is discussed.
description: 18 pages, 8 figures
Avapritinib: First Approval
Creators: name: Sohita Dhillon
Publisher: name: Adis Journals
Year: 2020
Subjects: subject: Medicine
subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: FOS: Clinical medicine

description: Compliance with Ethical Standards
Funding The preparation of this review was not supported by any external funding.
Conflict of interest During the peer review process the manufacturer of the agent under review was offered an opportunity to comment on the article. Changes resulting from any comments received were made by the authors on the basis of scientific completeness and accuracy. S. Dhillon, a contracted employee of Adis International Ltd/Springer Nature, is responsible for the article content and declares no relevant conflicts of interest.
Additional information about this Adis Drug Review can be found here

AbstractAvapritinib (AYVAKIT™) is a potent and selective tyrosine kinase inhibitor of platelet-derived growth factor receptor alpha (PDGFRA) and KIT activation loop mutants. It is being developed by Blueprint Medicines for the treatment of gastrointestinal stromal tumours (GIST), solid tumours and systemic mastocytosis. Avapritinib is approved in the USA for PDGFRA exon 18 (including D842V) mutant GIST and is undergoing regulatory assessment in the USA as a 4th-line treatment for GIST. Avapritinib is also undergoing regulatory assessment in the EU for PDGFRA D842V mutant GIST. This article summarizes the milestones in the development of avapritinib leading to this first approval for the treatment of adults with unresectable or metastatic GIST harbouring a PDGFRA exon 18 mutation, including PDGFRA D842V mutations. Clinical development of avapritinib is also underway for the treatment of systemic mastocytosis and late-stage solid tumours in several countries.

© Springer Nature Switzerland AG 2020
Additional file 1 of Evaluating the long-term impact of COVID-19-associated public health interventions on zoonotic and vector-borne diseases in China: an interrupted time series analysis
Creators: name: Wang, Yongbin
name: Qing, Siyu
name: Lan, Xianxiang
name: Li, Lun
name: Zhou, Peiping
name: Xi, Yue
name: Liang, Ziyue
name: Zhang, Chenguang
name: Xu, Chunjie
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Table S1. Decomposed seasonal index for the seven zoonotic and vector-borne diseases based on classical multiplicative decomposition. Table S2. Identified possible ARFIMA with the AIC, CAIC, BIC, and LL values. Table S3. The resulting ARFIMA modes with their corresponding information criteria for HFRS. Table S4. The resulting ARFIMA modes with their corresponding information criteria for rabies. Table S5. The resulting ARFIMA modes with their corresponding information criteria for leptospirosis. Table S6. The resulting ARFIMA modes with their corresponding information criteria for malaria. Table S7. Comparison of the predictive ability for HFRS under the ARIMA and ARFIMA. Figure S1. The incidence cases and rates of the seven zoonotic and vector-borne diseases. Figure S2. ACF and PACF plots for the seasonally and non-seasonally differenced HFRS incidence series. The significant spikes at lags 2 and 3 in the PACF indicate that the maximum orders may be 3 in the non-seasonal AR component, and the significant spike at lag 12 in the ACF suggests that the maximum orders may be 1 in the seasonal AR component. The significant spikes at lags 2 and 3 in the ACF suggest that the maximum orders may be 3 in the non-seasonal MA component, and the significant spike at lag 12 in the ACF suggests that the maximum orders may be 1 in the seasonal MA component. Figure S3. ACF and PACF analyses for the errors from the ARFIMA. a HFRS series residuals, b Rabies residual series, c DF residual series, d HB residual series, e Leptospirosis residual series, f Malaria residual series, and g Schistosomiasis residual series. Here the correlogram showed that few spikes exceeded the estimated significance limits, which is also reasonable in that some high-order correlations easily exceed that by chance alone, suggesting that there is little evidence of non-white noise in the residual series of the seven zoonotic and vector-borne diseases.
Steroid hormone secretion after stimulation of mineralocorticoid and NMDA receptors and cardiovascular risk in patients with depression
Creators: name: Nowacki, Jan
name: Wingenfeld, Katja
name: Kaczmarczyk, Michael
name: Chae, Woo Ri
name: Salchow, Paula
name: Abu-Tir, Ikram
name: Piber, Dominique
name: Hellmann-Regen, Julian
name: Otte, Christian
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: steroid
subject: MDD
subject: depression
subject: cardiovascular risk
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Major depressive disorder (MDD) is associated with altered mineralocorticoid receptor (MR) and glucocorticoid receptor function, and disturbed glutamatergic signaling. Both systems are closely intertwined and likely contribute not only to the pathophysiology of MDD, but also to the increased cardiovascular risk in MDD patients. Less is known about other steroid hormones, such as aldosterone and DHEA-S, and how they affect the glutamatergic system and cardiovascular disease risk in MDD. We examined salivary cortisol, aldosterone, and DHEA-S secretion after stimulation of MR and glutamatergic NMDA receptors in 116 unmedicated depressed patients, and 116 age- and sex-matched healthy controls. Patients (mean age = 34.7 years, SD = ±13.3; 78% women) and controls were randomized to four conditions: (a) control condition (placebo), (b) MR stimulation (0.4 mg fludrocortisone), (c) NMDA stimulation (250 mg D-cycloserine (DCS)), and (d) combined MR/NMDA stimulation (fludrocortisone + DCS). We additionally determined the cardiovascular risk profile in both groups. DCS had no effect on steroid hormone secretion, while cortisol secretion decreased in both fludrocortisone conditions across groups. Independent of condition, MDD patients showed (1) increased cortisol, increased aldosterone, and decreased DHEA-S concentrations, and (2) increased glucose levels and decreased high-density lipoprotein cholesterol levels compared with controls. Depressed patients show profound alterations in several steroid hormone systems that are associated both with MDD pathophysiology and increased cardiovascular risk. Prospective studies should examine whether modulating steroid hormone levels might reduce psychopathology and cardiovascular risk in depressed patients.
p-Mechanics and Field Theory
Creators: name: Kisil, Vladimir V.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Quantum Physics (quant-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: The orbit method of Kirillov is used to derive the p-mechanical brackets [math-ph/0007030, quant-ph/0212101]. They generate the quantum (Moyal) and classic (Poisson) brackets on respective orbits corresponding to representations of the Heisenberg group. The extension of p-mechanics to field theory is made through the De Donder--Weyl Hamiltonian formulation. The principal step is the substitution of the Heisenberg group with Galilean. Keywords: Classic and quantum mechanics, Moyal brackets, Poisson brackets, commutator, Heisenberg group, orbit method, deformation quantisation, representation theory, De Donder--Weyl field theory, Galilean group, Clifford algebra, conformal Möbius transformation, Dirac operator.
description: 12 pages (AMS-LaTeX); v2: some misprints are corrected; v3: many minor corrections suggested by a referee
Cheumatopsyche incomptaria Mey 1998
Creators: name: Oláh, János
name: Johanson, Kjell Arne
name: Barnard, Peter C.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Hydropsychidae
Cheumatopsyche
Cheumatopsyche incomptaria

description: Cheumatopsyche incomptaria Mey, 1998
 Cheumatopsyche incomptaria Mey, 1998b: 561.
 Type locality: Philippines.
description: Published as part of Oláh, János, Johanson, Kjell Arne & Barnard, Peter C., 2008, Revision of the Oriental and Afrotropical species of Cheumatopsyche Wallengren (Hydropsychidae, Trichoptera), pp. 1-171 in Zootaxa 1738 on page 136