cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Diet of the chub mackerel Scomber japonicus in the eastern Adriatic Sea
Creators: name: ČIKEŠ KEČ, Vanja
name: ZORICA, Barbara
name: SINOVČIĆ, Gorenka
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2012

description: Scomber japonicus is a pelagic fish species that is widely distributed around the world. The sample of chub mackerel (N = 400) in this study was collected during 2007 and 2008, from the commercial purse seine catches in the eastern part of the Adriatic Sea. Nine taxonomic groups of prey were found in the stomachs of chub mackerel. Decapoda (31.6%) was the most abundant prey in terms of number of individuals, while Mysida (63.4%) was the most frequently occurring prey item. Prey abundance showed some seasonal differences and there was a significant correlation between the abundance of most of the prey groups and the size of the chub mackerel.
Supplementary material from Microbial communities in hummingbird feeders are distinct from floral nectar and influenced by bird visitation
Creators: name: Lee, Casie
name: Tell, Lisa
name: Hilfer, Tiffany
name: Vannette, Rachel L.
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Supplementary methods, figures and tables
Interfacial Dzyaloshinskii-Moriya interaction in perpendicularly-magnetized Pt/Co/AlO$_x$ ultrathin films measured by Brillouin light spectroscopy
Creators: name: Belmeguenai, Mohamed
name: Adam, Jean-Paul
name: Roussigné, Yves
name: Eimer, Sylvain
name: Devolder, Thibaut
name: Kim, Joo-Von
name: Cherif, Salim Mourad
name: Stashkevich, Andrey
name: Thiaville, André
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Spin waves in perpendicularly-magnetized Pt/Co/AlO$_x$/Pt ultrathin films with varying Co thicknesses (0.6-1.2 nm) have been studied with Brillouin light spectroscopy in the Damon-Eshbach geometry. The measurements reveal a pronounced nonreciprocal propagation, which increases with decreasing Co thicknesses. This nonreciprocity is attributed to an interfacial Dzyaloshinskii-Moriya interaction (DMI), which is significantly stronger than asymmetries resulting from surface anisotropies for such modes. Results are consistent with an interfacial DMI constant $D_s = -1.7 \pm 0.11$ pJ/m, which favors left-handed chiral spin structures. This suggests that such films below 1 nm in thickness should support novel chiral states like skyrmions.
description: 5 pages, 3 figures, 1 table
Quantenmetrologie mit Materiewellen
Creators: name: Klempt, Carsten
name: Rasel, Ernst M.
name: Lachmann, Maike D.
Publisher: name: Physikalisch-Technische Bundesanstalt (PTB)
Year: 2020
Subjects: Materiewellen
Atominterferometrie

description: Enthalten in PTB-Mitteilungen. Band 130 (2020), Heft 3. ISSN 0030-834X
(401020) William Roy
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
NF-κB suppresses ROS levels in BCR–ABL+ cells to prevent activation of JNK and cell death
Creators: name: Stein, S. J.
name: Baldwin, A. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Elevated levels of reactive oxygen species are found in most oncogenically transformed cells and are proposed to promote cellular transformation through mechanisms such as inhibition of phosphatases. BCR-ABL, the oncoprotein associated with the majority of chronic myelogenous leukemias, induces accumulation of intracellular ROS causing enhanced signaling downstream of PI3K. Previously we have shown that the transcription factor NF-κB is activated by BCR-ABL expression and is required for BCR-ABL-mediated cellular transformation. Inhibition of IKKβ and NF-κB leads to cell death through an unknown mechanism. Here, we analyze the potential involvement of NF-κB in moderating BCR-ABL-induced ROS levels to protect from death in response to cell stress. The data confirm that BCR-ABL promotes ROS levels and demonstrate that NF-κB prevents excessive ROS levels. Inhibition of NF-κB leads to an increase in ROS levels and to cell death controlled through ROS-induced JNK activity. The data demonstrate that one function for NF-κB in oncogenesis is the suppression of oncoprotein-induced ROS levels and that inhibition of NF-κB in some cancers, including CML, will increase ROS levels and promote cell death.
Cuapetes uncinatus sp. nov. (Crustacea: Decapoda: Pontoniinae) from Futuna Island, Eastern Pacific Ocean
Creators: name: BRUCE, Alexander J.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2012

description: A new pontoniine shrimp, Cuapetes uncinatus, is designated. A pair of specimens was collected from 105-160 m off Futuna Island. The Cuapetes tenuipes species group is discussed.
Monthly variation of length-weight relationship, condition factor and gonadosomatic index of megrim, Lepidorhombus whiffiagonis (Walbaum, 1792) (Osteichthyes: Scophthalmidae) from the eastern Adriatic Sea
Creators: name: ŠANTIĆ, Mate
name: MARKOV-PODVINSKI, Martina
name: PALLAORO, Armin
name: STAGLIČIĆ, Nika
name: JARDAS, Ivan
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2012

description: Monthly changes in length-weight relationships (LWRs), condition factor and gonadosomatic index (GSI) of megrim, Lepidorhombus whiffiagonis were studied. A total of 1354 specimens (683 males and 671 females) ranging from 9.0 to 35.9 cm in total length (TL) were collected in the eastern Adriatic Sea. Allometric parameter b values varied during the year; positive allometric growth was noted from November to May while in other months isometric growth was observed. The GSI reached maximum values in January and minimum in June. The condition factor was lowest after spawning (June) and highest at the recovery phase (September). Monthly variation of b values and condition factor of megrim were probably connected with the reproductive cycle as well as feeding activity and energy distribution. During summer, food energy was spent in somatic growth, while in winter it was converted in gonad development.
(401019) Caroline Roy
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Virus-specific mechanisms of carcinogenesis in hepatitis C virus associated liver cancer
Creators: name: McGivern, D. R.
name: Lemon, S. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The development of hepatocellular carcinoma (HCC) in persons who are persistently infected with hepatitis C virus (HCV) is a growing problem worldwide. Current antiviral therapies are not effective in many patients with chronic hepatitis C, and a greater understanding of the factors leading to progression to HCC will be necessary to design novel approaches to prevention of HCV-associated HCC. The lack of a small animal model of chronic HCV infection has hampered understanding of these factors. Since HCV is an RNA virus with little potential for integration of its genetic material into the host genome, the mechanisms underlying HCV promotion of cancer are likely to differ from other models of viral carcinogenesis. In patients persistently infected with HCV, chronic inflammation resulting from immune responses against infected hepatocytes is associated with progressive fibrosis and cirrhosis. Cirrhosis is an important risk factor for HCC independent of HCV infection, and a majority of HCV-associated HCC arises in the setting of cirrhosis. However, a significant minority arises in the absence of cirrhosis, indicating that cirrhosis is not a prerequisite for cancer. Other lines of evidence suggest that direct, virus-specific mechanisms may be involved. Transgenic mice expressing HCV proteins develop cancer in the absence of inflammation or immune recognition of the transgene. In vitro studies have revealed multiple interactions of HCV-encoded proteins with cell cycle regulators and tumor suppressor proteins, raising the possibility that HCV can disrupt control of cellular proliferation, or impair the cell's response to DNA damage. A combination of virus-specific, host genetic, environmental, and immune-related factors are likely to determine the progression to HCC in patients who are chronically infected with HCV. Here, we summarize current knowledge of the virus-specific mechanisms that may contribute to HCV-associated HCC.
Bone morphogenetic protein modulator BMPER is highly expressed in malignant tumors and controls invasive cell behavior
Creators: name: Lassmann, S.
name: Heinke, J.
name: Werner, M.
name: Moser, M.
name: Patterson, C.
name: Bode, C.
name: Rahner, S.
name: Kerber, M.
name: Mnich, L.
name: Helbing, T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Bone morphogenetic proteins (BMPs) are growth factors that exert important functions in cell proliferation, migration and differentiation. Till date, multiple human tumors have been reported to display a dysregulation of several members of the BMP pathway that is associated with enhanced malignant tumor growth and metastasis. BMPER (BMP endothelial cell precursor-derived regulator) is a direct BMP modulator that is necessary for BMPs to exert their full-range signaling activity. Moreover, BMPER is expressed by endothelial cells and their progenitors, and has pro-angiogenic features in these cells. Here, we describe the expression of BMPER in human specimens of lung, colon and cervix carcinomas and cell lines derived from such carcinomas. In contrast to healthy tissues, BMPER is highly expressed upon malignant deterioration. Functionally, loss of BMPER in the lung tumor cell line A549 impairs proliferation, migration, invasion as well as tumor cell-induced endothelial cell sprout formation. In contrast, stimulation of A549 cells with exogenous BMPER had no further effect. We found that the BMPER effect may be transduced by regulation of the BMP target transcription factor inhibitor of DNA binding 1 (Id1) and matrix metalloproteinases (MMPs) 9 and 2. These facilitators of cell migration are down-regulated when BMPER is absent. To prove the relevance of our in vitro results in vivo, we generated Lewis lung carcinoma cells with impaired BMPER expression and implanted them into the lungs of C57BL/6 mice. In this model, the absence of BMPER resulted in severely reduced tumor growth and tumor angiogenesis. Taken together, these data unequivocally demonstrate that the BMP modulator BMPER is highly expressed in malignant tumors and tumor growth is dependent on the presence of BMPER.
BO`YMADARON O`SIMLIGINING AYRIM SHIFOBAXSH TA`SIRLARI SHARHI
Creators: name: Kamalova, Zulayxo
Publisher: name: Zenodo
Year: 2023

description: Mazkur maqolada bo`ymodaron o`simligining xilma-xilligi, uning tarqalishi, shifobaxshligi hamda xalq tabobatida qo`llanilish metodologiyasi muhokama etiladi.
Defining MAP3 kinases required for MDA-MB-231 cell tumor growth and metastasis
Creators: name: Cuevas, B. D.
name: Cronan, M. R.
name: Granger, D. A.
name: Johnson, G. L.
name: Johnson, N. L.
name: Scott, J. E.
name: Nakamura, K.
name: Wang, J. G.
name: MacKman, N.
name: Dohlman, H. G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Analysis of patient tumors suggests multiple MAP3kinases (MAP3Ks) are critical for growth and metastasis of cancer cells. MAP3Ks selectively control the activation of ERK1/2, JNK, p38 and ERK5 in response to receptor tyrosine kinases and GTPases. We used MDA-MB-231 cells because of their ability to metastasize from the breast fat pad to distant lymph nodes for an orthotopic xenograft model to screen the function of seven MAP3Ks in controlling tumor growth and metastasis. Stable shRNA knockdown was used to inhibit the expression of each of the seven MAP3Ks, which were selected for their differential regulation of the MAPK network. The screen identified two MAP3Ks, MEKK2 and MLK3, whose shRNA knockdown caused significant inhibition of both tumor growth and metastasis. Neither MEKK2 nor MLK3 have been previously shown to regulate tumor growth and metastasis in vivo. These results demonstrated that MAP3Ks, which differentially activate JNK, p38 and ERK5 are necessary for xenograft tumor growth and metastasis of MDA-MB-231 tumors. The requirement for MAP3Ks signaling through multiple MAPK pathways explains why several members of the MAPK network are activated in cancer. MEKK2 was required for EGF receptor and Her2/Neu activation of ERK5, with ERK5 being required for metastasis. Loss of MLK3 expression increased mitotic infidelity and apoptosis in vitro. Knockdown of MEKK2 and MLK3 resulted in increased apoptosis in orthotopic xenografts relative to control tumors in mice, inhibiting both tumor growth and metastasis; MEKK2 and MLK3 represent untargeted kinases in tumor biology for potential therapeutic development.
Data encoding efficiency in pixel detector readout with charge information
Creators: name: Garcia-Sciveres, Maurice
name: Wang, Xinkang
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The average minimum number of bits needed for lossless readout of a pixel detector is calculated, in the regime of interest for particle physics where only a small fraction of pixels have a non-zero value per frame. This permits a systematic comparison of the readout efficiency of different encoding imple- mentations. The calculation is compared to the number of bits used by the FE-I4 pixel readout chip of the ATLAS experiment.
description: 13 pages, 6 figures
(401018) Marianne Laskie
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Port disturbance of the meiofauna and sediment biogeochemistry at the mouth of the Brisbane River, eastern Australia
Creators: name: GARCÍA, Rosa
name: JOHNSTONE, Ron W.
name: RUEDA, Jose L.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2012

description: The Port of Brisbane disturbance of the sedimentary environment at the mouth of the Brisbane River was assessed at the inner and outer river and in two periods following disturbance: 2 weeks (March) and 8 months (November) after dredging. Sediments in the inner river were dominated by silt, while in the outer river sediment were sandier. Total and organic carbon (TC and Corg) and total Kjeldahl nitrogen (TKN) were higher in the inner river, which could be an indication of higher organic loads. Ammonia (NH4-N) and nitrate (NO3-N) sediment profiles indicated suboxic conditions and denitrification in the inner river, as well as oxic conditions and nitrification at the outer river. Total meiofauna abundance and taxa composition was similar in both, the inner and outer river locations. For some individual taxa however, the suboxic sedimentary conditions in the inner river were adverse. Copepods, polychaetes and sipunculids abundance were lower in the inner river, and negatively correlated with fine sediments and high organic loads, and positively correlated with oxic conditions. Furthermore, the port strategic dredging operations had negative effects on the meiofauna of both locations. The abundance of most of the taxa in both the inner and outer river locations during March was lower at sites inside the dredged navigational channel than at the sites outside the channel. The meiofauna rapidly re-colonise the disturbed sediments as by November the abundances inside the channel considerably increased. The composition of the meiofaunal and nematode assemblage from different sites and months showed significant differences. The nematode assemblage at the mouth of the Brisbane River dominated by Sabatieria and Metalinhomoeus was characteristic of disturbed sediments.
supplementary information from Catastrophic dynamics limit Atlantic cod recovery.
Creators: name: Sguotti, Camilla
name: Otto, Saskia A.
name: Frelat, Romain
name: Langbehn, Tom J.
name: Ryberg, Marie Plambech
name: Lindegren, Martin
name: Durant, Joël M.
name: Stenseth, Nils Chr.
name: Möllmann, Christian
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Collapses and regime changes are pervasive in complex systems (such as marine ecosystems) governed by multiple stressors. The demise of Atlantic cod (Gadus morhua) stocks constitutes a text book example of the consequences of overexploiting marine living resources, yet the drivers of these nearly synchronous collapses are still debated. Moreover, it is still unclear why rebuilding of collapsed fish stocks such as cod is often slow or absent. Here, we apply the stochastic cusp model, based on catastrophe theory, and show that collapse and recovery of cod stocks are potentially driven by the specific interaction between exploitation pressure and environmental drivers. Our statistical modelling study demonstrates that for most of the cod stocks, ocean warming could induce a nonlinear discontinuous relationship between fishing pressure and stock size, which would explain hysteresis in their response to reduced exploitation pressure. Our study suggests further that a continuing increase in ocean temperatures will likely limit productivity and hence future fishing opportunities for most cod stocks of the Atlantic Ocean. Moreover, our study contributes to the ongoing discussion on the importance of climate and fishing effects on commercially exploited fish stocks, highlighting the importance of considering discontinuous dynamics in holistic ecosystem-based management approaches, particularly under climate change.
(401017) George Roy
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Synthesis and Structure of the First [2₂]Metallocenophanes
Creators: name: Hafner, Klaus
name: Mink, Carsten
name: Lindner, Hans Jörg
Publisher: name: Wiley
Year: 2023

description: The dark red Fe and colorless ZrCl2 complexes 2 are easily accessible from the doubly bridged biscyclopentadienes 1. The substantial torsion of the two eclipsing decks of the conformationally rigid ligand framework of 2 exposes the metal center and points to the potential of such complexes as catalysts for the stereoselective polymerization of alkenes.
The cocaine- and amphetamine-regulated transcript mediates ligand-independent activation of ERα and is an independent prognostic factor in node-negative breast cancer
Creators: name: O'connor, D. P.
name: Martin, F. M.
name: Millikan, R. C.
name: Bernards, R.
name: Crown, J. P.
name: Duffy, M. J.
name: Jirström, K.
name: Ryden, L.
name: Brennan, D. J.
name: Landberg, G.
name: Zagozdzon, R.
name: Gallagher, W. M.
name: Rexhepaj, E.
name: Laursen, H.
name: Culhane, A. C.
name: Mcgee, S. F.
name: Mccarthy, S.
name: Hewitt, S. M.
name: Kuhar, M. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Personalized medicine requires the identification of unambiguous prognostic and predictive biomarkers to inform therapeutic decisions. Within this context, the management of lymph node-negative breast cancer is the subject of much debate with particular emphasis on the requirement for adjuvant chemotherapy. The identification of prognostic and predictive biomarkers in this group of patients is crucial. Here, we demonstrate by tissue microarray and automated image analysis that the cocaine- and amphetamine-regulated transcript (CART) is expressed in primary and metastatic breast cancer and is an independent poor prognostic factor in estrogen receptor (ER)-positive, lymph node-negative tumors in two separate breast cancer cohorts (n = 690; P = 0.002, 0.013). We also show that CART increases the transcriptional activity of ERα in a ligand-independent manner via the mitogen-activated protein kinase pathway and that CART stimulates an autocrine/paracrine loop within tumor cells to amplify the CART signal. Additionally, we demonstrate that CART expression in ER-positive breast cancer cell lines protects against tamoxifen-mediated cell death and that high CART expression predicts disease outcome in tamoxifen-treated patients in vivo in three independent breast cancer cohorts. We believe that CART profiling will help facilitate stratification of lymph node-negative breast cancer patients into high- and low-risk categories and allow for the personalization of therapy.
(401016) Patrick Dunbar Ritchie
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Supplementary document for Using pretrained machine learning models to predict luminous and solar transmittance controllability of liquid crystal/polymer composites from microstructural images - 6547131.pdf
Creators: name: Kakiuchida, Hiroshi
name: SUZUKI, KENSUKE
name: Kojima, Takuto
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: Uncategorized

description: Suppl. text, table, and figures
Engraulis encrasicolus (Linnaeus, 1758) egg and larval distribution in the eastern coast of Tunisia in relation with environmental characteristics
Creators: name: ZARRAD, Rafik
name: GARCÍA, Alberto
name: ALEMANY, Francisco
name: JARBOUI, Othman
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2012

description: An ichthyoplankton survey was conducted on the eastern coast of Tunisia from the 10th to 18th August 2004 with the investigation of 68 stations. The sampling period corresponded to stratified summer conditions, with average SST 26.97°C. The thermocline was found between 25 and 50 m depth. The eastern coast of Tunisia was influenced by the water exchanges between the eastern and western Mediterranean. Anchovy eggs and larvae were a major component of the ichthyoplankton, representing 26 and 19% of the total mean fish egg and larval abundances, respectively. Their mean abundances were 108 eggs.10 m-2 and 112 larvae.10 m-2. The spawning areas were mainly located off the 100 m isobaths, with the maximum abundance occurring near the shelf break, as opposed to the inshore waters where anchovy eggs and larvae were practically absent. Depth was the main factor controlling the distribution of anchovy eggs and larvae. Larval transport from the spawning areas is made evident following southward to south-eastward directions.
Cubic-scaling iterative solution of the Bethe-Salpeter equation for finite systems
Creators: name: Ljungberg, Mathias P.
name: Koval, Peter
name: Ferrari, Francesco
name: Foerster, Dietrich
name: Sanchez-Portal, Daniel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The Bethe-Salpeter equation (BSE) is currently the state of the art in the description of neutral electron excitations in both solids and large finite systems. It is capable of accurately treating charge-transfer excitations that present difficulties for simpler approaches. We present a local basis set formulation of the BSE for molecules where the optical spectrum is computed with the iterative Haydock recursion scheme, leading to a low computational complexity and memory footprint. Using a variant of the algorithm we can go beyond the Tamm-Dancoff approximation (TDA). We rederive the recursion relations for general matrix elements of a resolvent, show how they translate into continued fractions, and study the convergence of the method with the number of recursion coefficients and the role of different terminators. Due to the locality of the basis functions the computational cost of each iteration scales asymptotically as $O(N^3)$ with the number of atoms, while the number of iterations is typically much lower than the size of the underlying electron-hole basis. In practice we see that , even for systems with thousands of orbitals, the runtime will be dominated by the $O(N^2)$ operation of applying the Coulomb kernel in the atomic orbital representation
supplementary information from Catastrophic dynamics limit Atlantic cod recovery
Creators: name: Sguotti, Camilla
name: Otto, Saskia A.
name: Frelat, Romain
name: Langbehn, Tom J.
name: Ryberg, Marie Plambech
name: Lindegren, Martin
name: Durant, Joël M.
name: Stenseth, Nils Chr.
name: Möllmann, Christian
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Collapses and regime changes are pervasive in complex systems (such as marine ecosystems) governed by multiple stressors. The demise of Atlantic cod (Gadus morhua) stocks constitutes a text book example of the consequences of overexploiting marine living resources, yet the drivers of these nearly synchronous collapses are still debated. Moreover, it is still unclear why rebuilding of collapsed fish stocks such as cod is often slow or absent. Here, we apply the stochastic cusp model, based on catastrophe theory, and show that collapse and recovery of cod stocks are potentially driven by the specific interaction between exploitation pressure and environmental drivers. Our statistical modelling study demonstrates that for most of the cod stocks, ocean warming could induce a nonlinear discontinuous relationship between fishing pressure and stock size, which would explain hysteresis in their response to reduced exploitation pressure. Our study suggests further that a continuing increase in ocean temperatures will likely limit productivity and hence future fishing opportunities for most cod stocks of the Atlantic Ocean. Moreover, our study contributes to the ongoing discussion on the importance of climate and fishing effects on commercially exploited fish stocks, highlighting the importance of considering discontinuous dynamics in holistic ecosystem-based management approaches, particularly under climate change.
New records of epibiont ciliates (Ciliophora) on Harpacticoida (Copepoda, Crustacea) from the Bay of Piran (Gulf of Trieste, Northern Adriatic)
Creators: name: FERNANDEZ-LEBORANS, Gregorio
name: CHATTERJEE, Tapas
name: GREGO, Mateja
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2012

description: This article deals with the report of ten suctorian ciliates viz. Conchacineta amphiasci (Precht, 1935), Conchacineta pusilla (Maupas, 1881), Veracineta tisbei (Guilcher, 1950), Rhabdophrya trimorpha Chatton & Collin, 1910, Ophryodendron pedicellatum Hincks, 1873, Thecacineta calix (Schröder, 1907), Actinocyathula sp., Acineta papillifera Keppen, 1888, Corynophrya columbiae Curds, 1987, Cucumophrya leptomesochrae Kunz, 1936 and one peritrich ciliate Cothurnia triangula (Precht, 1935) from Bay of Piran (Adriatic Sea) as epibionts on harpacticoid copepods (on genera Ameira, Typhlamphiascus, Enhydrosoma and Paramphiascella). All species of epibionts are recorded here for the first time from the Bay of Piran (Adriatic Sea), Slovenia. Representatives of meiofaunal copepod genera Typhlamphiascus, Enhydrosoma and Paramphiascella are also recorded here for the first time as host of epibiontic ciliates.
Characterizing ordinal concept development in 4-5 year old children
Creators: name: De Smedt, Bert
name: Slipenkyj, Michael
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Developmental Psychology
subject: Cognitive Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: In this study, we will analyze an existing dataset (e.g., Bakker et al., 2023) to investigate the following research questions: 1. Can we identify different profiles of ordinal concept understanding? 2. What features characterize these different profiles? 3. How do these profiles change over developmental time? To address our research questions we will use a latent transition analysis.
(401015) Jessie Dunbar
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A novel sampling theorem on the rotation group
Creators: name: McEwen, J. D.
name: Büttner, M.
name: Leistedt, B.
name: Peiris, H. V.
name: Wiaux, Y.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: We develop a novel sampling theorem for functions defined on the three-dimensional rotation group SO(3) by connecting the rotation group to the three-torus through a periodic extension. Our sampling theorem requires $4L^3$ samples to capture all of the information content of a signal band-limited at $L$, reducing the number of required samples by a factor of two compared to other equiangular sampling theorems. We present fast algorithms to compute the associated Fourier transform on the rotation group, the so-called Wigner transform, which scale as $O(L^4)$, compared to the naive scaling of $O(L^6)$. For the common case of a low directional band-limit $N$, complexity is reduced to $O(N L^3)$. Our fast algorithms will be of direct use in speeding up the computation of directional wavelet transforms on the sphere. We make our SO3 code implementing these algorithms publicly available.
description: 5 pages, 2 figures, minor changes to match version accepted for publication. Code available at http://www.sothree.org
(401014) Ralph McCulla Ritchie
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Aberrant Mer receptor tyrosine kinase expression contributes to leukemogenesis in acute myeloid leukemia
Creators: name: Schlegel, J.
name: Martinson, H.
name: McGranahan, A.
name: Sather, S.
name: Liang, X.
name: Graham, D. K.
name: Lee-Sherick, A. B.
name: Keating, A. K.
name: McGary, C. S.
name: Earp, H. S.
name: Hunsucker, S. A.
name: Cannon, C.
name: Eisenman, K. M.
name: Armistead, P. M.
name: Deryckere, D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Acute myeloid leukemia (AML) continues to be extremely difficult to treat successfully, and the unacceptably low overall survival rates mandate that we assess new potential therapies to ameliorate poor clinical response to conventional therapy. Abnormal tyrosine kinase activation in AML has been associated with poor prognosis and provides strategic targets for novel therapy development. We found that Mer receptor tyrosine kinase was over-expressed in a majority of pediatric (29/36, 80%) and adult (10/10, 100%) primary AML patient blasts at the time of diagnosis, and 100% of patient samples at the time of relapse. Mer was also found to be expressed in 12 of 14 AML cell lines (86%). In contrast, normal bone marrow myeloid precursors expressed little to no Mer. Following AML cell line stimulation with Gas6, a Mer ligand, we observed activation of prosurvival and proliferative signaling pathways, including phosphorylation of ERK1/2, p38, MSK1, CREB, ATF1, AKT and STAT6. To assess the phenotypic role of Mer in AML, two independent short-hairpin RNA (shRNA) constructs were used to decrease Mer expression in the AML cell lines Nomo-1 and Kasumi-1. Reduction of Mer protein levels significantly increased rates of myeloblast apoptosis two to threefold in response to serum starvation. Furthermore, myeloblasts with knocked-down Mer demonstrated decreased colony formation by 67–87%, relative to control cell lines (P<0.01). NOD-SCID-gamma mice transplanted with Nomo-1 myeloblasts with reduced levels of Mer had a significant prolongation in survival compared with mice transplanted with the parental or control cell lines (median survival 17 days in parental and control cell lines, versus 32–36 days in Mer knockdown cell lines, P<0.0001). These data suggest a role for Mer in acute myeloid leukemogenesis and indicate that targeted inhibition of Mer may be an effective therapeutic strategy in pediatric and adult AML.
Evolutionary history of Idas sp. Med (Bivalvia: Mytilidae), a cold seep mussel bearing multiple symbionts
Creators: name: LORION, Julien
name: HALARY, Sébastien
name: NASCIMENTO, Joana Do
name: SAMADI, Sarah
name: COULOUX, Arnaud
name: DUPERRON, Sébastien
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2012

description: Small mytilids of the genus Idas are related to the large mussels found worldwide at deep-sea hydrothermal vents and cold seeps. They are therefore keys to a better understanding of the colonization of vents and seeps by symbiont-bearing organisms, but still little is known about their biology. For this study, specimens of a mytilid referred to the genus Idas were collected from various substrates in a cold seep area near the Nile deep sea fan. Based on molecular and morphological data, all specimens are confirmed to belong to a single species of the genus Idas, which was previously shown to host six distinct bacterial symbionts. Its larval shell characteristics indicate a long planktonic phase, which could explain its close relationship to a mussel species that occurs in the Gulf of Mexico. 3-D FISH indicates the dominance of sulfur-oxidizing, methane-oxidizing and methylotrophic symbionts in all specimens analysed.
Bax deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation
Creators: name: Deshmukh, M.
name: Ryan Miller, C.
name: Gama, V.
name: Crowther, A. J.
name: Garcia, I.
name: Gershon, T. R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Neurogenesis requires negative regulation through differentiation of progenitors or their programmed cell death (PCD). Growth regulation is particularly important in the postnatal cerebellum, where excessive progenitor proliferation promotes medulloblastoma, the most common malignant brain tumor in children. We present evidence that PCD operates alongside differentiation to regulate cerebellar granule neuron progenitors (CGNPs) and to prevent medulloblastoma.
Supplementary Material from When one phenotype is not enough: divergent evolutionary trajectories govern venom variation in a widespread rattlesnake species.
Creators: name: Zancolli, Giulia
name: Calvete, Juan J.
name: Cardwell, Michael D.
name: Greene, Harry W.
name: Hayes, William K.
name: Hegarty, Matthew J.
name: Hans-Werner Herrmann
name: Holycross, Andrew T.
name: Lannutti, Dominic I.
name: Mulley, John F.
name: Libia Sanz
name: Travis, Zachary D.
name: Whorley, Joshua R.
name: Wüster, Catharine E.
name: Wüster, Wolfgang
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology

description: Understanding the origin and maintenance of phenotypic variation, particularly across a continuous spatial distribution, represents a key challenge in evolutionary biology. For this, animal venoms represent ideal study systems: they are complex, variable, yet easily quantifiable molecular phenotypes with a clear function. Rattlesnakes display tremendous variation in their venom composition, mostly through strongly dichotomous venom strategies, which may even coexist within a single species. Here, through dense, widespread population-level sampling of the Mojave rattlesnake, Crotalus scutulatus, we show that genomic structural variation at multiple loci underlies extreme geographical variation in venom composition, which is maintained despite extensive gene flow. Unexpectedly, neither diet composition nor neutral population structure explain venom variation. Instead, venom divergence is strongly correlated with environmental conditions. Individual toxin genes correlate with distinct environmental factors, suggesting that different selective pressures can act on individual loci independently of their co-expression patterns or genomic proximity. Our results challenge common assumptions about diet composition as the key selective driver of snake venom evolution and emphasize how the interplay between genomic architecture and local-scale spatial heterogeneity in selective pressures may facilitate the retention of adaptive functional polymorphisms across a continuous space.
(401013) William Buchan Ritchie
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Distinct roles for fibroblast growth factor signaling in cerebellar development and medulloblastoma
Creators: name: Moore, C.
name: Dutton, J. W.
name: Emmenegger, B. A.
name: Fogarty, M. P.
name: Singh, A. R.
name: Markant, S. L.
name: Read, T. A.
name: Brun, S. N.
name: Yang, C.
name: Hwang, E. I.
name: McKeehan, W. L.
name: Durden, D. L.
name: Wechsler-Reya, R. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Cerebellar granule neurons are the most abundant neurons in the brain, and a critical element of the circuitry that controls motor coordination and learning. In addition, granule neuron precursors (GNPs) are thought to represent cells of origin for medulloblastoma, the most common malignant brain tumor in children. Thus, understanding the signals that control the growth and differentiation of these cells has important implications for neurobiology and neuro-oncology. Our previous studies have shown that proliferation of GNPs is regulated by Sonic hedgehog (Shh), and that aberrant activation of the Shh pathway can lead to medulloblastoma. Moreover, we have demonstrated that Shh-dependent proliferation of GNPs and medulloblastoma cells can be blocked by basic fibroblast growth factor (bFGF). But while the mitogenic effects of Shh signaling have been confirmed in vivo, the inhibitory effects of bFGF have primarily been studied in culture. Here we demonstrate that mice lacking FGF signaling in GNPs exhibit no discernable changes in GNP proliferation or differentiation. In contrast, activation of FGF signaling has a potent effect on tumor growth: treatment of medulloblastoma cells with bFGF prevents them from forming tumors following transplantation, and inoculation of tumor-bearing mice with bFGF markedly inhibits tumor growth in vivo. These results suggest that activators of FGF signaling may be useful for targeting medulloblastoma and other Shh-dependent tumors.
(401012) Margaret Malvena Ritchie
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Mutant B-RAF regulates a Rac-dependent cadherin switch in melanoma
Creators: name: Burridge, K.
name: Monaghan-Benson, E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The ability of cells to invade into the dermis is a critical event in the development of cutaneous melanoma and ultimately an indicator of poor prognosis. However, the molecular events surrounding the acquisition of this invasive phenotype remain incompletely understood. Mutations in B-RAF are frequent in melanoma and are known to regulate the invasive phenotype. In this study, we sought to determine the molecular mechanisms controlling melanoma invasion. We found that mutant B-RAF signaling regulates a cadherin switch. In melanoma cells expressing mutant B-RAF we observed high levels of N-cadherin and low levels of E-cadherin. Depletion of mutant B-RAF, by siRNA, caused a decrease in the levels of N-cadherin and an increase in the levels of E-cadherin. Mechanistically, we found that this cadherin switch required the activity of Rac1 and its GEF, Tiam1, both of which show suppressed activity in the presence of mutant B-RAF. Consistent with the work of others, we found that depletion of mutant B-RAF decreased the invasive capacity of the melanoma cells. However, simultaneous depletion of B-RAF and Rac or Tiam1 resulted in invasive capacity similar to that of control cells. Taken together, our results suggest that mutant B-RAF signaling downregulates Tiam1/Rac activity resulting in an increase in N-cadherin levels and a decrease in E-cadherin levels and ultimately enhanced invasion.
(401011) Margaret Malvina McCulla
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.