cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Public perspectives on acquired brain injury rehabilitation and components of care: A Citizens’ Jury
Creators: name: Lannin, Natasha
name: M Coulter
name: K Laver
name: Nerida Hyett
name: J Ratcliffe
name: Holland, Anne
name: L Callaway
name: C English
name: P Bragge
name: Hill, Sophie
name: Unsworth, Carolyn
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2020 The Authors. Health Expectations published by John Wiley & Sons Ltd Background: Brain injury rehabilitation is an expensive and long-term endeavour. Very little published information or debate has underpinned policy for service delivery in Australia. Within the context of finite health budgets and the challenges associated with providing optimal care to persons with brain injuries, members of the public were asked ‘What considerations are important to include in a model of care of brain injury rehabilitation?’. Methods: Qualitative study using the Citizen Jury method of participatory research. Twelve adult jurors from the community and seven witnesses participated including a health services funding model expert, peak body representative with lived experience of brain injury, carer of a person with a brain injury, and brain injury rehabilitation specialists. Witnesses were cross-examined by jurors over two days. Results: Key themes related to the need for a model of rehabilitation to: be consumer-focused and supporting the retention of hope; be long-term; provide equitable access to services irrespective of funding source; be inclusive of family; provide advocacy; raise public awareness; and be delivered by experts in a suitable environment. A set of eight recommendations were made. Conclusion: Instigating the recommendations made requires careful consideration of the need for new models of care with flexible services; family involvement; recruitment and retention of highly skilled staff; and providing consumer-focused services that prepare individuals and their carers for the long term. Patient and public contribution: As jury members, the public deliberated information provided by expert witnesses (including a person with a head injury) and wrote the key recommendations.
Two new triterpenoids from the stems of Euphorbia royleana
Creators: name: Liu, Wen-Xing
name: Zhang, Man
name: Zhang, Ying-Jun
name: Zhao, Ping
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Two new triterpenoids, namely 24-methylene-5,24-dien-19(10→9)-abeo-8α,9β,10α-eupha-3β-ol (1) and 24-methyl-5,23-dien-19(10→9)-abeo-8α,9β,10α-eupha-3β-ol (2) were isolated from the stems of Euphorbia royleana, together with three known analogs. The structures of the new compounds were elucidated by extensive 1H NMR,13C NMR, HSQC, HMBC, 1H-1H COSY, ROESY and HR-MS spectroscopic analyses.
Supplemental_material – Supplemental material for A Foundational Assessment of the Effects of the Spread of COVID-19 Virus Infection and Related Activity Restrictions on Mental and Physical Health, Psychological Distress, and Suicidal Ideation in Japan
Creators: name: Kiuchi, Keita
name: Kishi, Katsumasa
name: Kanto Araki
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, Supplemental_material for A Foundational Assessment of the Effects of the Spread of COVID-19 Virus Infection and Related Activity Restrictions on Mental and Physical Health, Psychological Distress, and Suicidal Ideation in Japan by Keita Kiuchi, Katsumasa Kishi and Kanto Araki in Asia Pacific Journal of Public Health
Additional file 1 of Intestinal helminth infections and associated risk factors among adults in the Lao People’s Democratic Republic
Creators: name: Phonekeo, Sengaloun
name: Kounnavong, Sengchanh
name: Vonglokham, Manithong
name: Siengsounthone, Latsamy
name: Homsana, Anousin
name: Gummin, Sascha
name: Vounatsu, Penelope
name: Nittiyanant, Prawat
name: Worawichawong, Suchin
name: Aekplakorn, Wichai
name: Odermatt, Peter
name: Sayasone, Somphou
Publisher: name: figshare
Year: 2024
Subjects: subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Additional file 1. Weighted prevalence of intestinal helminth infections among adults enrolled in the study, stratified by province.
Assessing the supportiveness of healthcare environments’ light and color: Development and validation of the Light and Color Questionnaire (LCQ)
Creators: name: Lindahl, J
name: Thulesius, H
name: Rask, M
name: Wijk, H
name: Edvardsson, David
name: Elmqvist, C
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Aim: The aim of this study was to develop and evaluate a self-report instrument measuring patients’, family members’, and staff’s perceived support from light and color in the physical environment of an emergency department (ED)—the Light and Color Questionnaire (LCQ). Background: The physical care environment is an important part of a comprehensive caring approach in all levels of care not only for patients but also for family members and staff. However, no existing self-report questionnaire assessing the extent to which light and color are perceived as being supportive in the physical care environment from the users’ perspective was found. Method: The LCQ was developed as part of a pre–post study in which an ED serving 125,000 people was refurbished and remodeled using evidence-based design. The LCQ consists of six items for light and five items for color and assesses awareness/orientation, safety/security, functional abilities, privacy, personal control, and stimulation. The study was carried out in four steps: constructions of items, assessment of face validity, data collection, and data analysis. Result/Conclusion: Psychometric evaluation of the two versions, LCQ-Patient/Family member and LCQ-Staff, showed satisfactory content and internal validity (>90%) and high internal consistency (Cronbach’s coefficient α =.9) to support the use of the questionnaire for research and development purposes. Explorative factor analysis of a total of 600 questionnaire responses confirmed light and color as distinctive and independent dimensions creating perceptions of more or less supportiveness for respondents. The LCQ instrument may be useful for architects, administrators, and researchers of healthcare environments.
Recent advances in Cannabis sativa genomics research
Creators: name: Hurgobin, Bhavna
name: Oli, Muluneh
name: Welling, Matthew
name: Doblin, Monika
name: Bacic, Tony
name: Whelan, James
name: Lewsey, Mathew
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Cannabis (Cannabis sativa L.) is one of the oldest cultivated plants purported to have unique medicinal properties. However, scientific research of cannabis has been restricted by the Single Convention on Narcotic Drugs of 1961, an international treaty that prohibits the production and supply of narcotic drugs except under license. Legislation governing cannabis cultivation for research, medicinal and even recreational purposes has been relaxed recently in certain jurisdictions. As a result, there is now potential to accelerate cultivar development of this multi-use and potentially medically useful plant species by application of modern genomics technologies. Whilst genomics has been pivotal to our understanding of the basic biology and molecular mechanisms controlling key traits in several crop species, much work is needed for cannabis. In this review we provide a comprehensive summary of key cannabis genomics resources and their applications. We also discuss prospective applications of existing and emerging genomics technologies for accelerating the genetic improvement of cannabis.
A Pilot Investigation of the Social Attention and Communication Surveillance (SACS) Tool for the Early Identification of Autism in Tianjin, China (SACS-C)
Creators: name: Barbaro, Josephine
name: C Wang
name: J Wang
name: G Liu
name: Y Liang
name: Ifrah Abdullahi
name: Dissanayake, Anne
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © Copyright © 2020 Barbaro, Wang, Wang, Liu, Liang, Wang, Abdullahi and Dissanayake. Introduction: Autism spectrum disorder (ASD) comprises difficulties in social communication and restrictive and repetitive behaviors. Despite an increased global prevalence, little remains known about early detection and diagnosis of autism in Mainland China. Our aim was to conduct a pilot investigation of the implementation of an Australian tool, Social Attention and Communication Surveillance (SACS), in Tianjin, China (SACS-C) by trained professionals to identify autism early compared to the Checklist for Autism in Toddlers-23 (CHAT-23) completed by parents and professionals. Materials and Methods: A total of 10,514 children were monitored across 61 Community Health Service Centres in six Tianjin districts on the SACS-C at 12, 18, and 24 months of age following a half-day training of 225 child health practitioners. Children deemed at “high likelihood” for autism on either the SACS, CHAT-23, or both, were referred for developmental assessments at the Tianjin Women and Children's Health Centre (TWCHC). Results: A total of 87 children (0.8%) were identified at “high likelihood” on the SACS-C, of whom 57 (66%) were assessed for autism; 24 children were subsequently diagnosed with autism (42.1%), and the remaining 33 (57.9%) were diagnosed with developmental and/or language delays. The SACS-C had a positive predictive value (PPV) of 42.1%, a negative predictive value (NPV) of 99.8%, and sensitivity and specificity of 53.3 and 99.7%, respectively. Only 21 children were identified at “high risk” for autism on the CHAT-23 (0.2%), over four times fewer children than the SACS-C, with 14 children assessed for autism (66%); nine were diagnosed with autism (64.3%) and the remaining five children were diagnosed with developmental and/or language delays. The CHAT-23 had an overall PPV of 64.3%, NPV of 99.6%, sensitivity of 27.3%, and specificity of 99.9%. Conclusion: This was the first large-scale study identifying autism in 12–24-month-old children in China. We ascertained the feasibility of training community health practitioners to monitor infants and toddlers for the early signs of autism, and determined the effectiveness of their use of SACS-C which had a better balance between accuracy and sensitivity in detecting autism in contrast to the CHAT-23 which missed the majority of children with autism (72.7%) vs. the SACS-C (46.7%). Given the emphasis on identifying as many children with autism as possible in Mainland China, SACS-C was identified as the tool of choice by the TWCHC. However, more work is needed to improve the psychometric properties in using the SACS-C in Mainland China so that it is comparable to its use in Australia.
Supplemental material for Shared Living Experiences by Physicians have a Positive Impact on Mental Health Attitudes and Stigma among Medical Students: A Mixed-Methods Study
Creators: name: Martin, Andrés
name: Chilton, Julie
name: Paasche, Cecilia
name: Nabatkhorian, Nicole
name: Gortler, Hilary
name: Cohenmehr, Erica
name: Indigo Weller
name: Amsalem, Doron
name: Neary, Stephanie
Publisher: name: SAGE Journals
Year: 2020
Subjects: Education

description: Supplemental material, Supplemental_material for Shared Living Experiences by Physicians have a Positive Impact on Mental Health Attitudes and Stigma among Medical Students: A Mixed-Methods Study by Andrés Martin, Julie Chilton, Cecilia Paasche, Nicole Nabatkhorian, Hilary Gortler, Erica Cohenmehr, Indigo Weller, Doron Amsalem and Stephanie Neary in Journal of Medical Education and Curricular Development
Supp_Mat_edges_and_nodes – Supplemental material for Bioinformatics Analysis of Differentially Expressed Genes and miRNAs in Low-Grade Gliomas
Creators: name: Bendahou, Mohammed Amine
name: Azeddine Ibrahimi
name: Mahjouba Boutarbouch
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Supplemental material, Supp_Mat_edges_and_nodes for Bioinformatics Analysis of Differentially Expressed Genes and miRNAs in Low-Grade Gliomas by Mohammed Amine Bendahou, Azeddine Ibrahimi and Mahjouba Boutarbouch in Cancer Informatics
Additional file 1 of Importance of clinical parameters for cultivation of critical care thinking by online teaching of critical care medicine
Creators: name: Pan, Pan
name: Zheng, Min
name: Luo, Hongbo
name: Liu, Jinbang
name: Li, Lina
name: Su, Longxiang
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Statistics
subject: FOS: Mathematics
subject: Science Policy

description: Additional file 1: Table S1. The training program including 30 topics.
Parametric model order reduction of miniaturized energy harvesting modules
Creators: name: Yuan, Chengdong
Publisher: name: Universität Rostock
Year: 2024
Subjects: subject: 000 Generalities, Science
subject: 620 Engineering & allied operations

description: This thesis presents the application of mathematical model order reduction (MOR) and parametric model order reduction (pMOR) methods for generating accurate surrogates of energy harvesters. Differing from conventional non-parametric MOR approaches, multivariate moment matching-, matrix interpolation-, and algebraic parameterization-based pMOR methods are used to construct a parametric reduced-order model (pROM), which enables the preservation of the predefined parameters, e.g., boundary conditions, material properties, or geometrical parameters, in symbolic form within a pROM.
Lipidemic profile changes over a two-year intervention period: Who benefited most from the feel4diabetes program?
Creators: name: K Karatzi
name: Moschonis, George
name: E Botsi
name: S Liatis
name: K Tsochev
name: P De Miguel-Etayo
name: J Kivelä
name: K Wikström
name: R Dimova
name: E Antal
name: I Lamiquiz-Moneo
name: I Rurik
name: G Cardon
name: V Iotova
name: K Makrilakis
name: Y Manios
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Identification of participants’ characteristics who benefited most from large community-based intervention studies may guide future prevention initiatives in order to maximize their effectiveness. The current study aimed to examine the socio-demographic, anthropometric, and behavioral characteristics, as well as the health and eating perceptions of those who improved their lipidemic profile, in the Feel4Diabetes early screening and prevention program. In the present analyses, 1773 adults from families at high risk for developing type 2 diabetes mellitus (T2DM) were enrolled, receiving either the standard care or the more intensive intervention, and 33.3–55.2% of them improved one or more of their lipidemic indices by >5%. Women, people living in Southeastern Europe, coming from two-parent families, having higher financial security, educational level and better diet quality were associated with a 27–64% higher likelihood for benefiting from the program regarding one or more of their lipidemic profile indices. Participants who were overweight or obese (especially with central obesity), employed, with prolonged sedentary behavior, prone to emotional eating and perceiving their weight status as lower than their actual weight were 24–43% less likely to have benefited. These findings should guide future interventions, prioritizing regions in greater need, and being tailor-made to specific population characteristics in order to further improve their effectiveness.
Floral volatile composition of Jasminum sambac variants developed through colchicine
Creators: name: S, Vishnupandi
name: M, Ganga
name: K, Rajamani
name: S, Manonmani
name: G, Shobhana V
name: N, Manikanda Boopathi
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: Jasmines are commercially grown for their fragrant flowers and essential oil. The present study investigates the composition of the volatile compounds from flowers of Jasminum sambac cv. Ramanthapuram Gundumalli and its variants that were evolved through colchicine. GC-MS analysis revealed that the flowers possessed major terpenes and sesquiterpenes such as Linalool, α-farnesene, germacrene-D, geranyl Linalool and D-Limonene as well as benzenoids (including benzyl acetate, benzyl alcohol and (Z)-Cinnamyl benzoate). The relative abundance of these volatile compounds in the variants have shown higher percentages than their wild-type (parent) which indicates that the variants possessed enhanced volatile composition. The new variations generated in floral volatile composition of J. sambac through polyploidisation are likely to have significant impact on the loose flower and perfume industries. Besides, the identified unique compounds can also be used as metabolic signatures to characterise the novel variants.
Table_S4_R1 – Supplemental material for People With Parkinson’s Disease Exhibit Reduced Cognitive and Motor Cortical Activity When Undertaking Complex Stepping Tasks Requiring Inhibitory Control
Creators: name: Pelicioni, Paulo H. S.
name: R., Stephen
name: Okubo, Yoshiro
name: Sturnieks, Daina L.
name: Menant, Jasmine C.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: Neuroscience

description: Supplemental material, Table_S4_R1 for People With Parkinson’s Disease Exhibit Reduced Cognitive and Motor Cortical Activity When Undertaking Complex Stepping Tasks Requiring Inhibitory Control by Paulo H. S. Pelicioni, Stephen R. Lord, Yoshiro Okubo, Daina L. Sturnieks and Jasmine C. Menant in Neurorehabilitation and Neural Repair
sj-pdf-1-ajr-10.1177_1945892420972326 - Supplemental material for Effects of Omalizumab Treatment in Patients With Recalcitrant Nasal Polyposis and Mild Asthma: A Multicenter Retrospective Study
Creators: name: Armengot-Carceller, Miguel
name: Gómez-Gómez, María José
name: García-Navalón, Carmen
name: Doménech-Campos, Encarna
name: Muñoz-Fernández, Noelia
name: Miguel, Ainhoa García-Lliberós De
name: Marco-Algarra, Jaime
name: Palop-Cervera, Marta
name: Piñero, Alfonso García
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110315 Otorhinolaryngology
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-1-ajr-10.1177_1945892420972326 for Effects of Omalizumab Treatment in Patients With Recalcitrant Nasal Polyposis and Mild Asthma: A Multicenter Retrospective Study by Miguel Armengot-Carceller MD, PhD María José Gómez-Gómez MD, PhD Carmen García-Navalón MD Encarna Doménech-Campos Muñoz- Noelia Fernández MD, PhD MD, PhD Ainhoa García-Lliberós de Miguel MD, PhD Jaime Marco-Algarra MD, PhD Marta Palop-Cervera MD Alfonso García Piñero MD, PhD in American Journal of Rhinology & Allergy
SUPPLEMENTAL_MATERIAL – Supplemental material for Measurement properties of step tests for exercise capacity in COPD: A systematic review
Creators: name: Vilarinho, Rui
name: Caneiras, Cátia
name: Montes, António Mesquita
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 110314 Orthopaedics
subject: 110604 Sports Medicine
subject: FOS: Health sciences

description: Supplemental material, SUPPLEMENTAL_MATERIAL for Measurement properties of step tests for exercise capacity in COPD: A systematic review by Rui Vilarinho, Cátia Caneiras and António Mesquita Montes in Clinical Rehabilitation
Phomopamide A, a cyclic pentadepsipeptide with α-glucosidase inhibition activity from the endophytic fungus Diaporthe sp.
Creators: name: Yu, Zhonghua
name: Nong, Xinmiao
name: Wei, Shanshan
name: Wu, Gang
name: Qin, Qiaomei
name: Tan, Haibo
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Medicine
Pharmacology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: An undescribed cytotoxic cyclopeptide named phomopamide A (1) was isolated from Diaporthe sp., which is an endophytic fungus from Artemisia argyi. Phomopamide A (1) featured an pentadepsipeptide skeleton and composed of two Phe, one Val, one Leu, and one 2-hydroxyoctanoic acid units. The structure of this new compound was fully characterised on the basis of extensive spectroscopic analysis. Moreover, phomopamide A was evaluated for in vitro cyctotoxic and α-glucosidase inhibitory activity. As a result, phomopaminde A exhibited no cytotoxic activity against four tumour cell lines, while it showed a potent α-glucosidase inhibition effect with IC50 value of 62.35 µM.
The global prevalence of turnover intention among general practitioners: a systematic review and meta-analysis
Creators: name: X Shen
name: Jiang, Heng
name: H Xu
name: J Ye
name: C Lv
name: Z Lu
name: Y Gan
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2020, The Author(s). Background: General practitioners (GPs) are the foundation of any primary healthcare system. Their quality and quantity are directly associated with the effectiveness and quality of the health services of a nation. GPs’ shortage and turnover have become an important issue in developed and developing countries. An accurate estimate of turnover intention prevalence among GPs would have important health policy implications, but the overall prevalence is unknown. We aimed to summarize the global prevalence of turnover intention and associated factors among GPs. Methods: We systematically reviewed the PubMed, Embase, Web of Science and China National Knowledge Infrastructure (CNKI) databases from their inception up to May 2020, as well as the reference lists of all included studies. We included observational studies that reported data on turnover intention or their prevalence rate among GPs could be calculated based on the information provided. The prevalence rate of the turnover intentions was estimated using a random-effects meta-analysis. The heterogeneity was evaluated using I2 statistic. Differences by study level characteristics were estimated via subgroup analysis and meta-regression. Results: A total of 25 cross-sectional studies were included (a total of 27,285 participants). The prevalence of turnover intention was 0.47 (95% CI: 0.39–0.55). Those having a lower level of salary (OR = 1.38, 95% CI: 1.13–1.63) and job satisfaction (OR = 1.35, 95% CI: 1.12–1.70) or having lower level of morale (OR = 2.68, 95% CI: 1.56–3.80) had a higher intention. In contrast, GPs with a lower level of professional title had a lower turnover intention (OR = 0.81, 95% CI: 0.65–0.98). Conclusions: In this systematic review, approximately half of the GPs had the intention to leave their current posts worldwide. The factors associated with turnover intention were higher professional title, lower income level, lower job satisfaction and lower morale.
Effects of excess manganese on the xylem sap protein profile of tomato (Solanum lycopersicum) as revealed by shotgun proteomic analysis
Creators: name: L Ceballos‐Laita
name: E Gutierrez‐Carbonell
name: D Takahashi
name: A Lonsdale
name: A Abadía
name: Doblin, Monika
name: Bacic, Tony
name: M Uemura
name: J Abadía
name: AF López‐Millán
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Metal toxicity is a common problem in crop species worldwide. Some metals are naturally toxic, whereas others such as manganese (Mn) are essential micro‐nutrients for plant growth but can become toxic when in excess. Changes in the composition of the xylem sap, which is the main pathway for ion transport within the plant, is therefore vital to understanding the plant’s response(s) to metal toxicity. In this study we have assessed the effects of exposure of tomato roots to excess Mn on the protein profile of the xylem sap, using a shotgun proteomics approach. Plants were grown in nutrient solution using 4.6 and 300 μM MnCl2 as control and excess Mn treatments, respectively. This approach yielded 668 proteins reliably identified and quantified. Excess Mn caused statistically significant (at p ≤ 0.05) and biologically relevant changes in relative abundance (≥2‐fold increases or ≥50% decreases) in 322 proteins, with 82% of them predicted to be secretory using three different prediction tools, with more decreasing than increasing (181 and 82, respectively), suggesting that this metal stress causes an overall deactivation of metabolic pathways. Processes most affected by excess Mn were in the oxido‐reductase, polysaccharide and protein metabolism classes. Excess Mn induced changes in hydrolases and peroxidases involved in cell wall degradation and lignin formation, respectively, consistent with the existence of alterations in the cell wall. Protein turnover was also affected, as indicated by the decrease in proteolytic enzymes and protein synthesis‐related proteins. Excess Mn modified the redox environment of the xylem sap, with changes in the abundance of oxido‐reductase and defense protein classes indicating a stress scenario. Finally, results indicate that excess Mn decreased the amounts of proteins associated with several signaling pathways, including fasciclin‐like arabinogalactan‐proteins and lipids, as well as proteases, which may be involved in the release of signaling peptides and protein maturation. The comparison of the proteins changing in abundance in xylem sap and roots indicate the existence of tissue‐specific and systemic responses to excess Mn. Data are available via ProteomeXchange with identifier PXD021973.
sj-pdf-1-ome-10.1177_0030222820966928 - Supplemental material for Bereavement in Times of COVID-19: A Review and Theoretical Framework
Creators: name: Stroebe, Margaret
name: Schut, Henk
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, sj-pdf-1-ome-10.1177_0030222820966928 for Bereavement in Times of COVID-19: A Review and Theoretical Framework by Margaret Stroebe and Henk Schut in OMEGA—Journal of Death and Dying
Heparanase and the hallmarks of cancer
Creators: name: Krishnath Jayatilleke
name: Hulett, Mark
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2020, The Author(s). Heparanase is the only mammalian enzyme that cleaves heparan sulphate, an important component of the extracellular matrix. This leads to the remodelling of the extracellular matrix, whilst liberating growth factors and cytokines bound to heparan sulphate. This in turn promotes both physiological and pathological processes such as angiogenesis, immune cell migration, inflammation, wound healing and metastasis. Furthermore, heparanase exhibits non-enzymatic actions in cell signalling and in regulating gene expression. Cancer is underpinned by key characteristic features that promote malignant growth and disease progression, collectively termed the ‘hallmarks of cancer’. Essentially, all cancers examined to date have been reported to overexpress heparanase, leading to enhanced tumour growth and metastasis with concomitant poor patient survival. With its multiple roles within the tumour microenvironment, heparanase has been demonstrated to regulate each of these hallmark features, in turn highlighting the need for heparanase-targeted therapies. However, recent discoveries which demonstrated that heparanase can also regulate vital anti-tumour mechanisms have cast doubt on this approach. This review will explore the myriad ways by which heparanase functions as a key regulator of the hallmarks of cancer and will highlight its role as a major component within the tumour microenvironment. The dual role of heparanase within the tumour microenvironment, however, emphasises the need for further investigation into defining its precise mechanism of action in different cancer settings.
Additional file 2 of The revealing of a novel double bond reductase related to perilla ketone biosynthesis in Perilla frutescens
Creators: name: Zhou, Peina
name: Shao, Yongfang
name: Jiang, Zheng
name: Dang, Jingjie
name: Qu, Cheng
name: Wu, Qinan
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 2
What are the core competencies of a mental health nurse? Protocol for a concept mapping study
Creators: name: Nompilo Moyo
name: Jones, Martin
name: Cardwell, Rachel
name: Gray, Richard
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: This study aims to identify and contrast key stakeholder perspectives about the core competencies of mental health nurses. Mental health nurses provide much of the direct care and treatment to patients with mental disorders. The perspectives of users of mental health services, mental health nurses, mental health nurse clinical leaders, psychiatrists, and mental health nurse academics regarding the core competencies of a mental health nurse are informative to improve the quality of care given to patients. We will use concept mapping to compare and contrast the views of different stakeholder groups (n = 50, 10 per group) about the core competencies (knowledge, skills, and attitudes) of mental health nurses. There are six stages in concept mapping: preparation, generation of statements, structuring of statements, representation of statements, interpretation of maps, and utilisation of maps. The Good Reporting of A Mixed Methods Study (GRAMMS) checklist will guide this study. The final output is a “concept map” that can be used and interpreted to understand core mental health nursing competencies. This study will provide insight into the perceived core competencies of mental health nurses from a variety of perspectives.
Photonics4All App - Slovakian
Creators: name: Chorvat, Dusan
name: Chorvatova, Alzbeta Marcek
name: Horilova, Julia
name: Mateasik, Anton
Publisher: name: Zenodo
Year: 2016
Subjects: Photonics
Light
Science communication
learning
discovering
physics students
Teacher
App

description: The Photonics4All-App is one of the tools developed within the Photonics4All outreach program. This is the Slovakian version of the App.

This App has mostly been developed to address young people (via their smartphones and tablets). It was also used for promotion of photonics for the large public (the young people’s parents to start with). The main objective of the App is to provide basic knowledge on photonics through interactive and fun games/activities included in the App.

The Photonics4All-App contains five different modules:

• Module 1: Basics Photonics concepts

• Module 2 : Photonics for ICT

• Module 3 : Photonics for Health & life science

• Module 4 : Photonics for Energy, lighting and display

• Module 5 : Photonics for Security, Metrology and sensors

Each module contains many chapters. Each chapter consists of explaining a specific concept and is organized in 3 steps:

- Understand: In this step, the concept is explained as simply as possible.

- Experiment: In this step, simulations or animations are used in order to experiment the concept.

- Quiz: In this step, youth or students will test whether they understand the concept or not (3 questions maximum)

Opticsvalley will take into account user’s feedback, so the tool will be evaluative and adapted to the real needs of young people.
Mahamanalactone A, a new triterpenoid from Dysoxylum malabaricum bark: a case study for rapid identification of new metabolites via LC-HRMS profiling and database mining strategy
Creators: name: Bhardwaj, Nivedita
name: S., Swathilakshmi
name: Tripathi, Nancy
name: Kumar, Sanjay
name: Lal, Uma Ranjan
name: G., Ravikanth
name: Guru, Santosh Kumar
name: Jain, Shreyans K.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer

description: In this recent investigation, the focus centred on exploring the potential phytoconstituents within the bark of Dysoxylum malabaricum. A profiling strategy employing LC-HRMS (Liquid Chromatography-High Resolution Mass Spectrometry) was implemented for the rapid identification of compounds from the bark extract. The crude extract underwent fractionation, resulting in the isolation of four previously known compounds (1–4) and a novel cycloartane triterpenoid named Mahamanalactone A (5). Compound 5 represents a cycloartane triterpenoid with a modified ring-A, featuring £-caprolactone fusion at positions 4 and 5, distinguishing it from other reported compounds where £-caprolactone is typically fused at positions 3 and 4. Cytotoxicity assessment revealed that the newly identified compound 5 exhibited a moderate cytotoxic profile (IC50 29 to 78 µM) against a panel of cancer cell lines.
Women's experiences and expectations after disclosure of intimate partner abuse to a healthcare provider: A qualitative meta-synthesis
Creators: name: L Tarzia
name: MA Bohren
name: J Cameron
name: C Garcia-Moreno
name: L O'Doherty
name: R Fiolet
name: Hooker, Leesa
name: M Wellington
name: R Parker
name: J Koziol-Mclain
name: G Feder
name: K Hegarty
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2020 The Author(s) Objective To identify and synthesise the experiences and expectations of women victim/survivors of intimate partner abuse (IPA) following disclosure to a healthcare provider (HCP). Methods The databases MEDLINE, Embase, CINAHL, PsychINFO, SocINDEX, ASSIA and the Cochrane Library were searched in February 2020. Included studies needed to focus on women's experiences with and expectations of HCPs after disclosure of IPA. We considered primary studies using qualitative methods for both data collection and analysis published since 2004. Studies conducted in any country, in any type of healthcare setting, were included. The quality of individual studies was assessed using an adaptation of the Critical Appraisal Skills Programme checklist for qualitative studies. The confidence in the overall evidence base was determined using Grading of Recommendations, Assessment, Development and Evaluations (GRADE)-Confidence in the Evidence from Reviews of Qualitative Research methods. Thematic synthesis was used for analysis. Results Thirty-one papers describing 30 studies were included in the final review. These were conducted in a range of health settings, predominantly in the USA and other high-income countries. All studies were in English. Four main themes were developed through the analysis, describing women's experiences and expectations of HCPs: (1) connection through kindness and care; (2) see the evil, hear the evil, speak the evil; (3) do more than just listen; and (4) plant the right seed. If these key expectations were absent from care, it resulted in a range of negative emotional impacts for women. Conclusions Our findings strongly align with the principles of woman-centred care, indicating that women value emotional connection, practical support through action and advocacy and an approach that recognises their autonomy and is tailored to their individual needs. Drawing on the evidence, we have developed a best practice model to guide practitioners in how to deliver woman-centred care. This review has critical implications for practice, highlighting the simplicity of what HCPs can do to support women experiencing IPA, although its applicability to low-income and-middle income settings remains to be explored.
Additional file 1 of Inhibition of DRP1-dependent mitochondrial fission by Mdivi-1 alleviates atherosclerosis through the modulation of M1 polarization
Creators: name: Su, Ze-da-zhong
name: Li, Chun-qiu
name: Wang, Hua-wei
name: Zheng, Min-ming
name: Chen, Qing-wei
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1 : Table S1. Primer sequences used for qRT-PCR analysis.
Photonics4All App - Swedish
Creators: name: Arnborg, Johan
Publisher: name: Zenodo
Year: 2016
Subjects: Photonics
Light
Science communication
learning
discovering
physics students
Teacher
App

description: The Photonics4All-App is one of the tools developed within the Photonics4All outreach program.  This is the Swedish version of the App.

This App has mostly been developed to address young people (via their smartphones and tablets). It was also used for promotion of photonics for the large public (the young people’s parents to start with). The main objective of the App is to provide basic knowledge on photonics through interactive and fun games/activities included in the App.

The Photonics4All-App contains five different modules:

• Module 1: Basics Photonics concepts

• Module 2 : Photonics for ICT

• Module 3 : Photonics for Health & life science

• Module 4 : Photonics for Energy, lighting and display

• Module 5 : Photonics for Security, Metrology and sensors

Each module contains many chapters. Each chapter consists of explaining a specific concept and is organized in 3 steps:

- Understand: In this step, the concept is explained as simply as possible.

- Experiment: In this step, simulations or animations are used in order to experiment the concept.

- Quiz: In this step, youth or students will test whether they understand the concept or not (3 questions maximum)

Opticsvalley will take into account user’s feedback, so the tool will be evaluative and adapted to the real needs of young people.
Mitochondrial RNA in Alzheimer’s disease circulating extracellular vesicles
Creators: name: KM Kim
name: Q Meng
name: O Perez De Acha
name: M Mustapic
name: A Cheng
name: E Eren
name: G Kundu
name: Y Piao
name: R Munk
name: WH Wood
name: S De
name: JH Noh
name: M Delannoy
name: Sim, Lesley
name: K Abdelmohsen
name: D Kapogiannis
name: M Gorospe
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © Copyright © 2020 Kim, Meng, Perez de Acha, Mustapic, Cheng, Eren, Kundu, Piao, Munk, Wood, De, Noh, Delannoy, Cheng, Abdelmohsen, Kapogiannis and Gorospe. Alzheimer’s disease (AD) is the most common type of dementia. Amyloid β (Aβ) plaques, tau-containing neurofibrillary tangles, and neuronal loss leading to brain atrophy are pathologic hallmarks of AD. Given the importance of early diagnosis, extensive efforts have been undertaken to identify diagnostic and prognostic biomarkers for AD. Circulating extracellular vesicles (EVs) provide a platform for “liquid biopsy” biomarkers for AD. Here, we characterized the RNA contents of plasma EVs of age-matched individuals who were cognitively normal (healthy controls (HC)) or had mild cognitive impairment (MCI) due to AD or had mild AD dementia (AD). Using RNA sequencing analysis, we found that mitochondrial (mt)-RNAs, including MT-ND1-6 mRNAs and other protein-coding and non-coding mt-RNAs, were strikingly elevated in plasma EVs of MCI and AD individuals compared with HC. EVs secreted from cultured astrocytes, microglia, and neurons after exposure to toxic conditions relevant to AD pathogenesis (Aβ aggregates and H2O2), contained mitochondrial structures (detected by electron microscopy) and mitochondrial RNA and protein. We propose that in the AD brain, toxicity-causing mitochondrial damage results in the packaging of mitochondrial components for export in EVs and further propose that mt-RNAs in plasma EVs can be diagnostic and prognostic biomarkers for MCI and AD.
Chemical constituents from the stem barks of Calophyllum recurvatum P.F. Stevens and Calophyllum andersonii P.F. Stevens, and their in-vitro hepatotoxic activity
Creators: name: Firouz, Noor Syarafana
name: Karunakaran, Thiruventhan
name: Mokhtar, Norisha
name: Santhanam, Rameshkumar
name: Jong, Vivien Yi Mian
name: Abu Bakar, Mohamad Hafizi
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology

description: Bioactive phenolics can be found in abundance in Calophyllum species. Phytochemical studies are carried out on the stem bark of Calophyllum recurvatum and Calophyllum andersonii, which has led to the isolation and elucidation of phytochemicals, thwaitesixanthone (1), teysmanone A (2), soulattrolide (3), calanone (4), isocalanone (5) and friedelin (6), respectively. The cytotoxic activities of compounds (2), (3), (4) and (5) as well as plant extracts were tested against HeLa Chang liver, HepG2 and HL-7702 cell lines. Phenylpyranocoumarins, teysmanone A (2) and soulattrolide (3) portrayed appreciable cytotoxicity activities at 42.57 ± 1.20 and 34.53 ± 3.41 µg/mL, respectively against HepG2 cell line comparable to the positive control, curcumin. Meanwhile, n-hexane extract from C. recurvatum exhibited cytotoxicity with the IC50 value of 36.43 ± 0.64 and 26.25 ± 4.83 µg/mL against HeLa Chang liver and HepG2 cell lines. All the tested compounds and plant extracts displayed non-cytotoxic properties on HL-7702 cell line.
Preparation of isoquercitrin and rhamnose from readily accessible rutin by a highly specific recombinant α-L-rhamnosidase (r-Rha1)
Creators: name: Chen, Yufei
name: Wang, Liwei
name: Guo, Yuao
name: Zhang, Mingjing
name: Xie, Haicheng
name: Xia, Guohua
name: Xu, Lili
name: Yang, Huan
name: Shen, Yuping
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology

description: Isoquercitrin has superior in vivo bioactivities with respect to its primary glycoside rutin. Its conventional preparation was ineffective, with large chemical consumption and many by-products. Rhamnose, a high value-added monosaccharide, is usually separated from acid hydrolytes of rutin. This study aimed to establish a novel enzymatic hydrolysis-based approach for their preparation. α-L-rhamnosidase was expressed in Pichia pastoris GS115 and applied to enzymolysis of rutin. Then, one-factor-at-a-time optimisation of hydrolysis conditions was performed. Two compounds were produced in 0.02 M HAc-NaAc buffer (pH4.50) containing α-L-rhamnosidase/rutin (1:4, w/w) at 60 °C. Consequently, 20.0 g/L rutin was completely hydrolysed in 2 hrs, and isoquercitrin was obtained after purification by HPD-100 resin. Additionally, rhamnose was enriched by decolorisation and crystallisation. MD simulation analysis suggested that rutin was catalysed on the hydrophobic surface of r-Rha1 with van-der-Waals force being main driving force. This strategy is an efficient approach for preparation of isoquercitrin and rhamnose.
DS_10.1177_0022034520963584 – Supplemental material for Molecular Basis for Craniofacial Phenotypes Caused by Sclerostin Deletion
Creators: name: J. Chen
name: X. Yuan
name: I. Pilawski
name: X. Liu
name: J. Delgado-Calle
name: T. Bellido
name: H. Turkkahraman
name: J.A. Helms
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine
subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, DS_10.1177_0022034520963584 for Molecular Basis for Craniofacial Phenotypes Caused by Sclerostin Deletion by J. Chen, X. Yuan, I. Pilawski, X. Liu, J. Delgado-Calle, T. Bellido, H. Turkkahraman and J.A. Helms in Journal of Dental Research
Improving the lifetime of an out-patient implanted medical device using a novel flower pollination-based optimization algorithm in wban systems
Creators: name: KV Munivel
name: T Samraj
name: V Kandasamy
name: Chilamkurti, Naveen
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. The new inventions in health care devices have led to a considerable increase in the human lifespan. Miniaturized bio-sensing elements and dedicated wireless communication bands have led to the development of a new arena called Wireless Body Area Network (WBAN) (IEEE 802.11.6). These Implantable Medical Devices (IMDs) are used for monitoring a chronic patient’s medical condition as well as therapeutic and life-saving functions. The aim of this study is to improve the dynamic channel selection algorithm for an increased Out Patient-Body Network Controller (OP-BNC) medical device during visits to the hospital. There is a fixed number of licensed spectra allocated to the In Patient-Body Network Controller (IP-BNC) and Out-Patient Body Network Controller (OP-BNC). When there is an increase in the OP-BNC, there is an availability of idle spectrum in the IP-BNC. An existing rank-based algorithm is used in the allocation of idle spectrum to the increased OP-BNC. This ranking method takes more time for the processing and selection of an idle channel to the registered user. To avoid it, we proposed an EFPOC model to select from the free idle channels of the IP-BNC licensed spectrum. We also discussed the algorithm complexity of the proposed Enhanced Flower Pollination-based Optimized Channel selection (EFPOC) algorithm and obtained a complexity of O(n2), which is a significant improvement over the existing algorithm rank-based algorithm complexity. Our experimental result shows that the proposed EFPOC algorithm improves the Tier-2 systems lifetime by 46.47%. Then, to prove that the proposed model is time efficient in channel selection, a simulated experimented is conducted. When selecting a number of channels from a Look-Up Table (LUT), the proposed EFPOC method takes 25% less time than the existing algorithms.
Additional file 1 of The association of patient safety culture with intent to leave among Jordanian nurses: a cross-sectional study
Creators: name: Oweidat, Islam
name: Shosha, Ghada Abu
name: Dmaidi, Kawther
name: Nashwan, Abdulqadir J.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1