cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Motor Signs Predict Poor Outcomes in Alzheimer Disease
Creators: name: Scarmeas, Nikolaos
name: Albert, Marilyn
name: Brandt, Jason
name: Blacker, Deborah
name: Hadjigeorgiou, Georgios
name: Papadimitriou, Alexandros
name: Dubois, Bruno
name: Sarazin, Maria
name: Wegesin, Domonick
name: Marder, Karen
name: Bell, Karen L.
name: Honig, Lawrence S.
name: Stern, Yaakov
Publisher: name: Columbia University
Year: 2005
Subjects: Neurology
Alzheimer's disease
Movement disorders
Alzheimer's disease--Forecasting

description: OBJECTIVE: To examine whether the presence of motor signs has predictive value for important outcomes in Alzheimer disease (AD). METHODS: A total of 533 patients with AD at early stages (mean Folstein Mini-Mental State Examination [MMSE] 21/30 at entry) were recruited and followed semiannually for up to 13.1 years (mean 3) in five University-based AD centers in the United States and European Union. Four outcomes, assessed every 6 months, were used in Cox models: cognitive endpoint (Columbia Mini-Mental State Examination < or = 20/57 [ approximately MMSE < or = 10/30]), functional endpoint (Blessed Dementia Rating Scale > or = 10), institutionalization equivalent index, and death. Using a standardized portion of the Unified PD Rating Scale (administered every 6 months for a total of 3,149 visit-assessments, average 5.9 per patient), the presence of motor signs, as well as of individual motor sign domains, was examined as time-dependent predictor. The models controlled for cohort, recruitment center, sex, age, education, a comorbidity index, and baseline cognitive and functional performance. RESULTS: A total of 39% of the patients reached the cognitive, 41% the functional, 54% the institutionalization, and 47% the mortality endpoint. Motor signs were noted for 14% of patients at baseline and for 45% at any evaluation. Their presence was associated with increased risk for cognitive decline (RR, 1.72; 95% CI, 1.24 to 2.38), functional decline (1.80 [1.33 to 2.45]), institutionalization (1.68 [1.26 to 2.25]), and death (1.38 [1.05 to 1.82]). Tremor was associated with increased risk for reaching the cognitive and bradykinesia for reaching the functional endpoints. Postural-gait abnormalities carried increased risk for institutionalization and mortality. Faster rates of motor sign accumulation were associated with increased risk for all outcomes. CONCLUSIONS: Motor signs predict cognitive and functional decline, institutionalization, and mortality in Alzheimer disease. Different motor sign domains predict different outcomes.
Chaos in the Hamiltonian mean field model
Creators: name: Ginelli, Francesco
name: Takeuchi, Kazumasa A.
name: Chate', Hugues
name: Politi, Antonio
name: Torcini, Alessandro
Publisher: name: arXiv
Year: 2011
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We study the dynamical properties of the canonical ordered phase of the Hamiltonian mean-field (HMF) model, in which $N$ particles, globally-coupled via pairwise attractive interactions, form a rotating cluster. Using a combination of numerical and analytical arguments, we first show that the largest Lyapunov exponent remains strictly positive in the infinite-size limit, converging to its asymptotic value with $1/\ln N$ corrections. We then elucidate the scaling laws ruling the behavior of this asymptotic value in the critical region separating the ordered, clustered phase and the disordered phase present at high energy densities. We also show that the full spectrum of Lyapunov exponents consists of a bulk component converging to the (zero) value taken by a test oscillator forced by the mean field, plus subextensive bands of ${\cal O}(\ln N)$ exponents taking finite values. We finally investigate the robustness of these results by studying a "2D" extension of the HMF model where each particle is endowed with 4 degrees of freedom, thus allowing the emergence of chaos at the level of single particle. Altogether, these results illustrate the subtle effects of global (or long-range) coupling, and the importance of the order in which the infinite-time and infinite-size limits are taken: for an infinite-size HMF system represented by the Vlasov equation, no chaos is present, while chaos exists and subsists for any finite system size.
Perturbation theory for normal operators
Creators: name: Rainer, Armin
Publisher: name: arXiv
Year: 2011
Subjects: subject: Functional Analysis (math.FA)
subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 26C10, 26E10, 32B20, 47A55

description: Let $E \ni x\mapsto A(x)$ be a $\mathscr{C}$-mapping with values unbounded normal operators with common domain of definition and compact resolvent. Here $\mathscr{C}$ stands for $C^\infty$, $C^ω$ (real analytic), $C^{[M]}$ (Denjoy--Carleman of Beurling or Roumieu type), $C^{0,1}$ (locally Lipschitz), or $C^{k,α}$. The parameter domain $E$ is either $\mathbb R$ or $\mathbb R^n$ or an infinite dimensional convenient vector space. We completely describe the $\mathscr{C}$-dependence on $x$ of the eigenvalues and the eigenvectors of $A(x)$. Thereby we extend previously known results for self-adjoint operators to normal operators, partly improve them, and show that they are best possible. For normal matrices $A(x)$ we obtain partly stronger results.
description: 32 pages, Remark 7.5 on m-sectorial operators added, accepted for publication in Trans. Amer. Math. Soc
The Exeter Inn and the Potters of Litchdon Street, Barnstaple: North Devon Pottery in the 16th Century
Creators: name: Morris, Bryn
Publisher: name: Archaeology Data Service
Year: 2023

description: Medieval Ceramics: Journal of the Medieval Ceramics Research Group, 39, 61-74
description: This paper presents the discovery and excavation of a 16th-century pottery production site at the Exeter Inn, Litchdon Street, Barnstaple, and the analysis of this material, which represents a major step forward in our understanding of the products and working practices of the north Devon potteries, prior to their development as a major industry in the 17th century. The artefact assemblage consists of over 50,000 sherds of pottery as well as a considerable volume of ridge and floor tile, recovered from a complex series of very large intercutting pits, broadly divisible into earlier 16th-century and later 16th-century features. Analysis of the material has identified changing trends in the scale of production, the types of pottery produced, the clay used, and the level of clay processing undertaken. No kilns were located during the work, but analysis of fragments of kiln structure and slate separators has highlighted the potential of this material for exploring how pottery was fired and stacked. The assemblage included a small number of inlaid floor tiles very similar to examples in several west Somerset churches, re-dating those tiles to the late 15th or early 16th century. Lastly, the small number of stamped or scored sherds points to apotropaic practices with distinct religious overtones.
Estrogenic and anti-neutrophilic inflammatory phenanthrenes from Juncus effusus L.
Creators: name: Hu, Hao-Chun
name: Tsai, Yi-Hong
name: Chuang, Yu-Che
name: Lai, Kuei-Hung
name: Hsu, Yu-Ming
name: Hwang, Tsong-Long
name: Lin, Chih-Chan
name: Fülöp, Ferenc
name: Wu, Yang-Chang
name: Yu, Szu-Yin
name: Kuo, Yu-Ting
name: Chang, Fang-Rong
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Juncus effusus L. (J. effusus) is a Traditional Chinese Medicine (TCM) that has long been used for dealing with gynaecological disorders, such as relieving insomnia, preventing tinnitus, reducing edema with diuretic effect. In our course of evidence-based medical research focused on this herb, one new phenanthrene, Junfusol B (2), together with seventeen known compounds were isolated and identified. All the structures of these compounds were elucidated by spectroscopic methods. The absolute stereochemistry of compounds 1 and 2 was further determined by comparing their calculated and experimental Electronic Circular Dichroism (ECD) spectra and optical rotation (OR) values. The isolates were evaluated for their estrogenic and anti-inflammatory activities which were considered as relevant etiological factors of insomnia, tinnitus and edema in the ancient TCM theory. The results revealed that most of the obtained phenanthrenes in this work were found exerting agonistic effects on estrogen receptor. This is the first report to declare the exact estrogen-regulating potential among this type of compounds from J. effusus. Moreover, phenanthrenes 3 − 7 exhibited significant inhibitions on superoxide anion generation and elastase release in fMLP/CB-induced human neutrophilic inflammation model. J. effusus may be developed as a complementary agent utilized in menopausal multiple syndromes.
Medieval and Post-Medieval Pottery Studies in South-West England: A Review
Creators: name: Allan, John
name: Dawson, David P
name: Mepham, Lorraine
Publisher: name: Archaeology Data Service
Year: 2023

description: Medieval Ceramics: Journal of the Medieval Ceramics Research Group, 39, 75-102
description: This paper presents a review of the state of pottery studies in the four historic counties of south-west England (Cornwall, Devon, Somerset and Dorset) and offers a guide to the production centres and principal consumer sites in the region. Coverage extends into Bristol, whose pottery is inseparable from that of Somerset. The unique Cornish tradition of wares spanning the post-Roman to Norman periods, which has seen important work in recent years is not discussed. The gazetteer in Part 2 is organised by historic county.
Simplifying Multiloop Integrands and Ultraviolet Divergences of Gauge Theory and Gravity Amplitudes
Creators: name: Bern, Z.
name: Carrasco, J. J. M.
name: Dixon, L. J.
name: Johansson, H.
name: Roiban, R.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We use the duality between color and kinematics to simplify the construction of the complete four-loop four-point amplitude of N=4 super-Yang-Mills theory, including the nonplanar contributions. The duality completely determines the amplitude's integrand in terms of just two planar graphs. The existence of a manifestly dual gauge-theory amplitude trivializes the construction of the corresponding N=8 supergravity integrand, whose graph numerators are double copies (squares) of the N=4 super-Yang-Mills numerators. The success of this procedure provides further nontrivial evidence that the duality and double-copy properties hold at loop level. The new form of the four-loop four-point supergravity amplitude makes manifest the same ultraviolet power counting as the corresponding N=4 super-Yang-Mills amplitude. We determine the amplitude's ultraviolet pole in the critical dimension of D=11/2, the same dimension as for N=4 super-Yang-Mills theory. Strikingly, exactly the same combination of vacuum integrals (after simplification) describes the ultraviolet divergence of N=8 supergravity as the subleading-in-1/N_c^2 single-trace divergence in N=4 super-Yang-Mills theory.
description: v2: PRD published version, fixed glitch in ancillary file. v1: 61 pages, 22 figures
Cortactin enhances elongation of axons in Drosophila melanogaster and is inhibited by calpain in vivo
Creators: name: Mains, Victoria Roslynne
Publisher: name: University of British Columbia
Year: 2012

description: The nervous system of an organism is exceedingly complex and yet highly specific in the connections that it makes. The mechanisms by which a functional nervous system is developed are therefore of great importance and interest. Neurons extend processes over long distances and through various environments in order to form connections with their appropriate targets. The neurites must sense their environment and make decisions based on guidance cues as to which direction to grow. The growth cone of the developing neurite is a dynamic, actin-rich domain at the leading edge and is the site for integration of various guidance cues and, therefore, of this decision making. The molecular mechanisms underlying outgrowth, in particular consolidation of developing axons – the process in which the actin network of the proximal region of the growth cone collapses creating a new segment of axon, remain unclear. Our lab previously uncovered a role for the actin-associated protein cortactin as an enhancer of membrane protrusions in cultured neurons and for calpain as an inhibitor of this process in consolidated regions. However, the physiological roles for cortactin and calpain in axon outgrowth and cell migration have remained elusive as others have observed both similar and opposite effects of these proteins. These discrepancies are likely due to the variability associated with in vitro studies. Therefore, I set out to elucidate the function of these molecules in developing axons in vivo within the model organism Drosophila melanogaster. Using two subsets of neurons within the central nervous system, I observed that the overexpression of cortactin combined with the inhibition of calpain increased the elongation of axons as well as the incidence of misguidance. Therefore, it appears that in vivo, cortactin acts as an enhancer of membrane protrusions and elongation and is actively inhibited by calpain. In addition, these two proteins appear to influence guidance, though through what mechanism remains to be investigated. Knowledge of the molecular pathways involved in axon outgrowth and guidance is key to the understanding of not only development, but also plasticity and repair within the nervous system.
Polyisoprenylated benzophenones and xanthones from the pericarp of Garcinia planchonii Pierre
Creators: name: Trinh, Duong H.
name: Huynh, Oanh N.
name: Nguyen, Trung Q.
name: Nguyen, Hieu T.
name: Nguyen, Thao-Ly T.
name: Pham, Hung D.
name: Nguyen, Lien-Hoa D.
name: Tran, Phuong T.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Two new polyisoprenylated benzophenones, planchoniones A (1) and B (2), together with two known benzophenones (3, 4) and six known xanthones (5-10), were isolated from an ethyl acetate extract of the pericarp of Garcinia planchonii Pierre. Their structures were established using spectroscopic methods, mainly 1D and 2D NMR. The four benzophenones were evaluated for their cytotoxicity against MCF-7 human breast cancer cells, and showed almost no activity. Meanwhile, compounds 5-10 were investigated for their inhibitory effects towards α-glucosidase, and γ-mangostin (5) exhibited the most remarkable effect with IC50 value of 15.3 ± 0.9 µM (compared with acarbose, IC50 = 224.9 ± 3.6 µM).
Concentration estimates for the isoperimetric constant of the super critical percolation cluster
Creators: name: Procaccia, Eviatar B.
name: Rosenthal, Ron
Publisher: name: arXiv
Year: 2011
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: We consider the Cheeger constant $ϕ(n)$ of the giant component of supercritical bond percolation on $\mathbb{Z}^d/n\mathbb{Z}^d$. We show that the variance of $ϕ(n)$ is bounded by $\fracξ{n^d}$, where $ξ$ is a positive constant that depends only on the dimension $d$ and the percolation parameter.
description: 11 Pages, 1 figure
Dealloying of Platinum-Aluminum Thin Films Part II. Electrode Performance
Creators: name: Ryll, Thomas
name: Galinski, Henning
name: Schlagenhauf, Lukas
name: Rechberger, Felix
name: Sun, Ying
name: Gauckler, Ludwig J.
name: Mornaghini, Flavio C. F.
name: Ries, Yasmina
name: Spolenak, Ralph
name: Doebeli, Max
Publisher: name: arXiv
Year: 2011
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Highly porous Pt/Al thin film electrodes on yttria stabilized zirconia electrolytes were prepared by dealloying of co-sputtered Pt/Al films. The oxygen reduction capability of the resulting electrodes was analyzed in a solid oxide fuel cell setup at elevated temperatures. During initial heating to 523 K exceptionally high performances compared to conventional Pt thin film electrodes were measured. This results from the high internal surface area and large three phase boundary length obtained by the dealloying process. Exposure to elevated temperatures of 673 K or 873 K gave rise to degradation of the electrode performance, which was primarily attributed to the oxidation of remaining Al in the thin films.
description: 5 pages, 4 figures
Between Innovation and Tradition: A Case Study of Drinking Vessels from Medieval Vilnius
Creators: name: Urbonait�-Ub�, Migl�
Publisher: name: Archaeology Data Service
Year: 2023

description: Medieval Ceramics: Journal of the Medieval Ceramics Research Group, 40, 1-10
description: This paper focuses on late medieval (late 13th- to 15th-century) ceramic drinking vessels and related forms from Vilnius. The archaeological record from this period is very diverse and locally produced artefacts are abundant. Imported pottery, which mostly comprises vessels associated with storing, serving and consuming drink, is less common, but nonetheless provides valuable information on social and economic conditions in Vilnius during the medieval period. Following an introduction to the historical context, the sources and use of these imported wares, which include rare finds of Golden Horde ceramics, is discussed. As most excavated pottery is of local production, with only a small proportion of imported vessels, this suggests that new traditions were only adopted by a minority, while the rest of the community kept to their established ways. If so, vessels can be taken as evidence for the meeting of different cultural traditions.
Yamabe flow on manifolds with edges
Creators: name: Bahuaud, Eric
name: Vertman, Boris
Publisher: name: arXiv
Year: 2011
Subjects: subject: Analysis of PDEs (math.AP)
subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 53C44, 58J35, 35K08

description: Let (M,g) be a compact oriented Riemannian manifold with an incomplete edge singularity. This article shows that it is possible to evolve g by the Yamabe flow within a class of singular edge metrics. As the main analytic step we establish parabolic Schauder-type estimates for the heat operator on certain Hölder spaces adapted to the singular edge geometry. We apply these estimates to obtain local existence for a variety of quasilinear equations, including the Yamabe flow. This provides a setup for a subsequent discussion of the Yamabe problem using flow techniques in the singular setting.
description: 3 pages, 1 figure, v2: minor improvements, references added, organizational changes
Motor Impairment in PD: Relationship to Incident Dementia and Age
Creators: name: Levy, Gilberto
name: Tang, Mingxin
name: Cote, Lucien J.
name: Louis, Elan D.
name: Alfaro, Brenda
name: Mejia-Santana, Helen
name: Stern, Yaakov
name: Marder, Karen
Publisher: name: Columbia University
Year: 2000
Subjects: Neurology
Parkinson's disease--Patients
Dementia
Aging
Movement disorders

description: OBJECTIVE: To analyze the relationship of specific motor impairment in idiopathic PD to incident dementia. BACKGROUND: The total Unified PD Rating Scale (UPDRS) motor score at baseline has been associated with an increased risk of developing dementia in PD. METHODS: A cohort of 214 nondemented community-dwelling patients with PD was followed annually with neurologic and neuropsychological evaluations. The association of baseline motor impairment with incident dementia was analyzed using Cox proportional hazards models. Facial expression, tremor, rigidity, and bradykinesia were analyzed as part of subscore A (indicative of dopaminergic deficiency); speech and axial impairment were analyzed as part of subscore B (indicative of predominantly nondopaminergic deficiency). The correlation between the six motor domains and age was also analyzed. RESULTS: Of 173 patients followed for at least 1 year, 50 became demented according to the Diagnostic and Statistical Manual of Mental Disorders, revised 3rd edition (DSM III-R) criteria (mean follow-up, 3.6 +/- 2. 2 years). When both subscores A and B were entered into the Cox model, subscore B was associated with incident dementia (relative risk = 1.19; 95% CI, 1.09 to 1.30; p = 0.0001), in addition to gender, age, and education, whereas subscore A was not (relative risk = 1.03; 95% CI, 0.99 to 1.07; p = 0.19). Of the six motor domains, speech and bradykinesia were associated with incident dementia (p < 0.05), and axial impairment approached significance (p = 0.06). Only axial impairment was correlated with age (correlation coefficient = 0.32; p < 0.001). CONCLUSION: The findings suggest that motor impairment mediated predominantly by nondopaminergic systems is associated with incident dementia in PD. Axial impairment may be the result of a combined effect of the disease and the aging process.
Three new naphthoquinones from the tubers of Sinningia mauroana
Creators: name: Winiewski, Vanessa
name: Fonseca, Mariana Mesquita
name: Salvador, Marcos José
name: de Sá, Eduardo Lemos
name: Stefanello, Maria Élida Alves
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Cancer
subject: Plant Biology

description: Three new naphthoquinones, 5,6,7-trimethoxydunnione (1), 6,7-dimethoxy-α-dunnione (2), and 5,6,7-trimethoxydunniol (3) were isolated from the tubers of Sinningia mauroana Chautems, together with eleven known compounds: 5-hydroxy-6,7-dimethoxy-α-dunnione (4), 6-hydroxy-7-methoxy-α-dunnione (5), 7-hydroxy-6-methoxy-α-dunnione (6), cedrol (7), tectoquinone (8), plantainoside A (9), calceolarioside A (10), calceolarioside B (11), sanangoside (12), allo-calceolarioside A (13), and conandroside (14). The known compounds 4, 7–9 and 11–13 are being reported for the first time in this species. Hexane, ethyl acetate and ethanol extracts were tested for antioxidant activity by the ORAC-FL method, and the antioxidant capacity was measured as trolox equivalent (TE). The ethyl acetate (8808 µg TE g−1) and ethanol (7911 µg TE g−1) extracts showed high antioxidant capacity, while the hexane extract displayed weak antioxidant capacity (860 µg TE g−1).
Chemical, antioxidant and cytotoxic profile of hydroalcoholic extracts of plants from Southern Brazil and their activity against pathogenic fungi isolated from dogs and cats with sensitivity and resistance to conventional antifungals
Creators: name: Giordani, Claudia
name: Waller, Stefanie Bressan
name: Madrid, Isabel Martins
name: Guterres, Karina Affedlt
name: de Matos, Caroline Bohnen
name: Hoffmann, Jessica Fernanda
name: de Castro, Luciana Laitano
name: Chaves, Fábio Clasen
name: de Faria, Renata Osório
name: Cleff, Marlete Brum
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology

description: We aimed to evaluate the chemical, antioxidant, cytotoxic, and antifungal activities of hydroalcoholic extracts of native plants from Southern Brazil: Schinus terebinthifolia (SCH), Persicaria hydropiperoides (PER), Eugenia uniflora (EUG) and Equisetum hyemale (EQU). Ethyl gallate, quercetin, and quinic acid were prevalent compounds identified by LC-MS. For total phenolic/flavonoid contents and the antioxidant potential against ABTS/DPPH radicals, the ascending order was EQU 75%) at concentrations up to 12.5 mg/mL (MTT assay). By M38-A2/M27-A3 (CLSI) against 68 clinical isolates of animals and strains of Malassezia pachydermatis, Sporothrix brasiliensis, Microsporum canis, Microsporum gypseum and Trichophyton mentagrophytes, all extracts (MIC/MFC ≤3.13–100 mg/mL) were active, except EUG. SCH inhibited and killed S. brasiliensis (MIC/MFC50/90 3.12–12.5 mg/mL) and dermatophytes (MIC/MFC 6.25–25 mg/mL) resistant to ketoconazole and itraconazole. These findings support the promising use of the selected plant extracts as antifungal agents.
Effects of inert species in the gas phase in a model for the catalytic oxidation of CO
Creators: name: Buendia, G. M.
name: Rikvold, P. A.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We study by kinetic Monte Carlo simulations the catalytic oxidation of carbon monoxide on a surface in the presence of contaminants in the gas phase. The process is simulated by a Ziff-Gulari-Barshad (ZGB) model that has been modified to include the effect of the contaminants and to eliminate the unphysical oxygen-poisoned phase. The impurities can adsorb and desorb on the surface, but otherwise remain inert. We find that, if the impurities can not desorb, no matter how small their proportion in the gas mixture, the first order transition and the reactive window that characterize the ZGB model disappear. The coverages become continuous, and once the surface has reached a steady state there is no production of CO$_2$. This is quite different from the behavior of a system in which the surface presents a fixed percentage of impurities. When the contaminants are allowed to desorb, the reactive window appears again, and disappears at a value that depends on the proportion of contaminants in the gas and on their desorption rate.
description: 12 pages
Applications of penalized likelihood methods for feature selection in statistical modeling
Creators: name: Xu, Chen
Publisher: name: University of British Columbia
Year: 2012

description: Feature selection plays a pivotal role in knowledge discovery and contemporary scientific research. Traditional best subset selection or stepwise regression can be computationally expensive or unstable in the selection process, and so various penalized likelihood methods (PLMs) have received much attention in recent decades. In this dissertation, we develop approaches based on PLMs to deal with the issues of feature selection arising from several application fields. Motivated by genomic association studies, we first address feature selection in ultra-high-dimensional situations, where the number of candidate features can be huge. Reducing the dimension of the data is essential in such situations. We propose a novel screening approach via the sparsity-restricted maximum likelihood estimator that removes most of the irrelevant features before the formal selection. The model after screening serves as an excellent starting point for the use of PLMs. We establish the screening and selection consistency of the proposed method and develop efficient algorithms for its implementation. We next turn our attention to the analysis of complex survey data, where the identification of influential factors for certain behavioral, social, and economic indices forms a variable selection problem. When data are collected through survey sampling from a finite population, they have an intrinsic dependence structure and may provide a biased representation of the target population. To avoid distorted conclusions, survey weights are usually adopted in these analyses. We use a pseudo-likelihood to account for the survey weights and propose a penalized pseudo-likelihood method for the variable selection of survey data. The consistency of the proposed approach is established for the joint randomization framework. Lastly, we address order selection for finite mixture models, which provides a flexible tool for modeling data from a heterogeneous population. PLMs are attractive for such problems. However, this application requires maximizations over nonsmooth and nonconcave objective functions, which are computationally challenging. We transform the original multivariate objective function into a sum of univariate functions and design an iterative thresholding-based algorithm to efficiently solve the sparse maximization without ad hoc steps. We establish the convergence of the new algorithm and illustrate its efficiency through both simulations and real-data examples.
QCD quark cyclobutadiene and light tetraquark spectrum
Creators: name: Deng, Chengrong
name: Ping, Jialun
name: Wang, Fan
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The QCD quark cyclobutadiene (ring-like), a new color structure of tetraquark system, is proposed and studied in the flux tube model with multi-body confinement potential. The QCD quark cyclobutadiene and other flux tube structures of tetraquark states have similar energies and they can be regarded as QCD isomeric compounds. The light tetraquark spectra ($u, d, s$ only) with ring-like and diquark-antidiquark structures are calculated in the flux tube model. The results show that many experimental states have the masses close to the calculated values if they are taken as tetraquark states. The isotensor states with $J^{PC}=1^{--}$ and $J^{PC}=2^{++}$ are studied and predicted that the masses are around 1500 MeV. The multi-body interaction plays a important role to reduce the energy of the multiquark state.
description: 10 pages, 4 figures, Some statements are changed
Memory and Executive Function Impairment Predict Dementia in Parkinson's Disease
Creators: name: Levy, Gilberto
name: Jacobs, Diane
name: Tang, Mingxin
name: Cote, Lucien J.
name: Louis, Elan D.
name: Alfaro, Brenda
name: Mejia-Santana, Helen
name: Stern, Yaakov
name: Marder, Karen
Publisher: name: Columbia University
Year: 2002
Subjects: Movement disorders
Parkinson's disease
Executive functions (Neuropsychology)
Dementia
Neurology

description: We analyzed the association of neuropsychological test impairment at baseline with the development of dementia in idiopathic Parkinson's disease (PD) patients. A cohort of nondemented PD patients from northern Manhattan, NY was followed annually with neurological and neuropsychological evaluations. The neuropsychological battery included tests of verbal and nonverbal memory, orientation, visuospatial ability, language, and abstract reasoning. The association of baseline neuropsychological tests scores with incident dementia was analyzed using Cox proportional hazards models. The analysis controlled for age, gender, education, duration of PD, and the total Unified Parkinson's Disease Rating Scale motor score at baseline. Forty-five out of 164 patients (27%) became demented during a mean follow-up of 3.7 ± 2.3 years. Four neuropsychological test scores were significantly associated with incident dementia in the Cox model: total immediate recall (RR: 0.92, 95% CI: 0.87–0.97, P = 0.001) and delayed recall (RR: 0.73, 95% CI: 0.59–0.91, P = 0.005) of the Selective Reminding Test (SRT), letter fluency (RR: 0.87, 95% CI: 0.77–0.99, P = 0.03), and Identities and Oddities of the Mattis Dementia Rating Scale (RR: 0.85, 95% CI: 0.73–0.98, P = 0.03). When the analysis was performed excluding patients with a clinical dementia rating of 0.5 (questionable dementia) at baseline evaluation, total immediate recall and delayed recall were still predictive of dementia in PD. Our results indicate that impairment in verbal memory and executive function are associated with the development of dementia in patients with PD.
Production of Pottery and Brickware Objects at Teteghem, Hauts-De-France. Recent Discoveries Dating to the 12th And 14th Centuries
Creators: name: Vincent, Vaiana
name: Lan�On, Mathieu
Publisher: name: Archaeology Data Service
Year: 2023

description: Medieval Ceramics: Journal of the Medieval Ceramics Research Group, 40, 23-38
description: Teteghem is situated in the maritime plain of Northern France, just 3km from the Belgian border and historically within the County of Flanders, an environment with variable sedimentary deposits such as clay and sand suitable for pottery production. Recent archaeological surveys and excavations have yielded evidence for pottery and tile manufacture on two sites dating to the 12th and 14th centuries, and, more unusually, for the production of bricks and brickware objects on the later site. This paper presents the finds from these sites, with a summary of the fabrics, forms and decoration represented and a more detailed consideration of the brickware objects; the discussion places these artefacts in their north-west European context.
Cyclopentenone and wickerol derivatives from the marine algicolous fungus Trichoderma atroviride A-YMD-9-4
Creators: name: Yin, Xiu-Li
name: Song, Yin-Ping
name: Liu, Xiang-Hong
name: Ji, Nai-Yun
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Inorganic Chemistry
subject: 60506 Virology

description: A new cyclopentenone derivative, 4-hydroxyhypocrenone A, and a new naturally-occurring wickerol derivative, 8-acetoxywickerol A, as well as two known compounds, hypocrenone A and wickerol B, were purified from Trichoderma atroviride A-YMD-9-4, an endophytic fungus isolated from the marine red alga Gracilaria verrucosa. The structures and relative configurations of two new isolates were established by a combination of 1 D/2D NMR, IR, and mass spectroscopic methods, and the absolute configuration of 1 was assigned on the basis of ECD data analyzed by quantum chemical calculations. Compounds 1 and 2 exhibited weak inhibition of one or two marine phytoplankton species.
Mortality and Apolipoprotein E in Hispanic, African-American, and Caucasian Elders
Creators: name: Lee, Joseph H.
name: Tang, Mingxin
name: Schupf, Nicole
name: Stern, Yaakov
name: Jacobs, Diane
name: Tycko, Benjamin
name: Mayeux, Richard Paul
Publisher: name: Columbia University
Year: 2001
Subjects: Medical genetics
Apolipoprotein E
Older African Americans
Older Hispanic Americans
Mortality

description: To investigate whether mortality risk is influenced by apolipoprotein E (APOE) genotype and whether the risk differs by ethnicity, we compared the mortality risk in 2,112 individuals ≥ 65 years of age residing in northern Manhattan in New York. Mortality risks associated with the APOE genotype, adjusted for sex, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides, differed significantly by ethnic group. Among Caucasian and Hispanics, the E2/E3 genotype was associated with the lowest mortality risk in the multivariate Cox proportional hazards modeling, adjusted for lipid levels, whereas mortality risk did not differ substantially between the E4/E3 and E3/E3 genotypes. Among African-Americans, the E2/E3 genotype was not associated with the lowest mortality risk, but the E4/E3 genotype was. Adjustment for heart disease, diabetes, and stroke reduced mortality risk associated with each genotype by about 50% for all ethnic groups, but the patterns remained the same. Although we cannot rule out the possibility of a healthy survival bias, our analyses designed to examine healthy survival by comparing risk of mortality in groups who were younger or older at entry do not support this possibility. Our findings suggest that the APOE genotype is associated with mortality and that the genotypic risks differ by ethnic group. Nearly 50% of the mortality risk associated with the APOE genotype appears to act through major chronic diseases, but those diseases only partially explain the mechanism by which the genotypic risk acts. To better understand the observed ethnic differences in mortality risk by genotype, a detailed prospective study is needed to examine the relationships among APOE, other candidate genes, health conditions, and eventual death.
Indole diketopiperazine alkaloids and aromatic polyketides from the Antarctic fungus Penicillium sp. SCSIO 05705
Creators: name: Hu, Yi-Wei
name: Chen, Wei-Hao
name: Song, Meng-Meng
name: Pang, Xiao-Yan
name: Tian, Xin-Peng
name: Wang, Fa-Zuo
name: Liu, Yong-Hong
name: Wang, Jun-Feng
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: A new indole diketopiperazine alkaloid, named penilline D (1), together with five known indole alkaloid analogues (2–5, 11), two meroterpenoids (6 and 12), and four butenolide derivatives (7–10), were isolated from the Antarctic fungus Penicillium sp. SCSIO 05705. Extensive spectroscopic analysis and electronic circular dichroism (ECD) calculation were used to elucidate the structure of penilline D (1), including its absolute configuration. All isolated compounds (1–12) were evaluated for their cytotoxic, antibacterial and enzyme inhibitory activities against acetylcholinesterase (AChE) and pancreatic lipase (PL). Among them, compound 5 exhibited moderate in vitro cytotoxic activity against the 143B cell line with IC50 value of 12.64 ± 0.78 μM. Compound 6 showed strong inhibitory activity against AChE with IC50 value of 0.36 nM (IC50 18.7 nM for Tacrine), while compounds 6 and 11 showed weak PL enzyme inhibitory activity. Furthermore, an in silico molecular docking study was also performed between 6 and AChE.
Time-reversal symmetric Kitaev model and topological superconductor in two dimensions
Creators: name: Nakai, Ryota
name: Ryu, Shinsei
name: Furusaki, Akira
Publisher: name: arXiv
Year: 2011
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: A time-reversal invariant Kitaev-type model is introduced in which spins (Dirac matrices) on the square lattice interact via anisotropic nearest-neighbor and next-nearest-neighbor exchange interactions. The model is exactly solved by mapping it onto a tight-binding model of free Majorana fermions coupled with static Z_2 gauge fields. The Majorana fermion model can be viewed as a model of time-reversal invariant superconductor and is classified as a member of symmetry class DIII in the Altland-Zirnbauer classification. The ground-state phase diagram has two topologically distinct gapped phases which are distinguished by a Z_2 topological invariant. The topologically nontrivial phase supports both a Kramers' pair of gapless Majorana edge modes at the boundary and a Kramers' pair of zero-energy Majorana states bound to a 0-flux vortex in the π-flux background. Power-law decaying correlation functions of spins along the edge are obtained by taking the gapless Majorana edge modes into account. The model is also defined on the one-dimension ladder, in which case again the ground-state phase diagram has Z_2 trivial and non-trivial phases.
description: 17 pages, 9 figures
Modeling the Influence of Extrapyramidal Signs on the Progression of Alzheimer's Disease
Creators: name: Stern, Yaakov
name: Liu, Xinhua
name: Albert, Marilyn
name: Brandt, Jason
name: Jacobs, Diane
name: Del Castillo-Castaneda, Caridad
name: Marder, Karen
name: Bell, Karen L.
name: Sano, Mary
name: Bylsma, Fred
Publisher: name: Columbia University
Year: 1996
Subjects: Neurology
Extrapyramidal disorders
Alzheimer's disease--Patients
Alzheimer's disease--Forecasting
Medicine

description: Objective: To determine how the advent of extrapyramidal signs influences the progression of Alzheimer disease as measured by standard clinical measures. Design: We applied growth curve models to prospective data to characterize patients' cognitive and functional changes over time. To detect changes in disease course related to extrapyramidal signs, their onset was treated as a time-dependent covariate. Setting: Three research medical centers. Participants: Patients (n=217) with probable Alzheimer disease. Intervention: Patients were followed up semiannually for 5 years. Main Outcome Measures: Scores on the modified Mini-Mental State Examination and measures of basic and instrumental activities of daily living from the Blessed Dementia Rating Scale. Results: For basic and instrumental activities of daily living, disease course was more rapid once extrapyramidal signs developed. Decline in the modified Mini-Mental State Examination score was greater at the time the signs developed, but not at subsequent visits. Conclusions: The point at which extrapyramidal signs emerge is associated with measurable acceleration in the progression of Alzheimer disease. This may in part explain why extrapyramidal signs are associated with a poorer prognosis. The differential influence of extrapyramidal signs on cognitive and functional measures suggests that the pathological changes underlying these disease features may vary.
Spectroscopy on a single trapped 137Ba+ ion for nuclear magnetic octupole moment determination
Creators: name: Lewty, Nicholas C.
name: Chuah, Boon Leng
name: Cazan, Radu
name: Sahoo, B. K.
name: Barrett, M. D.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We present precision measurements of the hyperfine intervals in the 5D3/2 manifold of a single trapped Barium ion, 137 Ba+ . Measurements of the hyperfine intervals are made between mF = 0 sublevels over a range of magnetic fields allowing us to interpolate to the zero field values with an accuracy below a few Hz, an improvement on previous measurements by three orders of magnitude. Our results, in conjunction with theoretical calculations, provide a 30-fold reduction in the uncertainty of the magnetic dipole (A) and electric quadrupole (B) hyperfine constants. In addition, we obtain the magnetic octupole constant (C) with an accuracy below 0.1 Hz. This gives a subsequent determination of the nuclear magnetic octupole moment, Ω, with an uncertainty of 1% limited almost completely by the accuracy of theoretical calculations. This constitutes the first observation of the octupole moment in 137 Ba+ and the most accurately determined octupole moment to date.
description: 4 pages, 3 figures
Mediterranean Diet and Risk for Alzheimer's Disease
Creators: name: Scarmeas, Nikolaos
name: Stern, Yaakov
name: Tang, Mingxin
name: Mayeux, Richard Paul
name: Luchsinger, Jose A.
Publisher: name: Columbia University
Year: 2006
Subjects: Neurology
Cooking, Mediterranean
Diet
Alzheimer's disease

description: OBJECTIVE: Previous research in Alzheimer's disease (AD) has focused on individual dietary components. There is converging evidence that composite dietary patterns such as the Mediterranean diet (MeDi) is related to lower risk for cardiovascular disease, several forms of cancer, and overall mortality. We sought to investigate the association between MeDi and risk for AD. METHODS: A total of 2,258 community-based nondemented individuals in New York were prospectively evaluated every 1.5 years. Adherence to the MeDi (zero- to nine-point scale with higher scores indicating higher adherence) was the main predictor in models that were adjusted for cohort, age, sex, ethnicity, education, apolipoprotein E genotype, caloric intake, smoking, medical comorbidity index, and body mass index. RESULTS: There were 262 incident AD cases during the course of 4 (+/-3.0; range, 0.2-13.9) years of follow-up. Higher adherence to the MeDi was associated with lower risk for AD (hazard ratio, 0.91; 95% confidence interval, 0.83-0.98; p = 0.015). Compared with subjects in the lowest MeDi tertile, subjects in the middle MeDi tertile had a hazard ratio of 0.85 (95% confidence interval, 0.63-1.16) and those at the highest tertile had a hazard ratio of 0.60 (95% confidence interval, 0.42-0.87) for AD (p for trend = 0.007). INTERPRETATION: We conclude that higher adherence to the MeDi is associated with a reduction in risk for AD. Ann Neurol 2006.
Mediterranean Diet and Mortality in a Us Population.[Comment]
Creators: name: Scarmeas, Nikolaos
name: Luchsinger, Jose A.
name: Mayeux, Richard Paul
name: Schupf, Nicole
name: Stern, Yaakov
Publisher: name: Columbia University
Year: 2008
Subjects: Cooking, Mediterranean
Diet
Mortality
Aging

description: In a recent study of a US population, Mitrou et al reported longer survival for subjects conforming more to the Mediterranean Diet (MeDi). A few months earlier, we had demonstrated that higher adherence to the MeDi was associated with reduced mortality in community-based Alzheimer disease (AD) patients who were identified in another US population in New York, New York. Considering subjects from the same New York study, we had previously demonstrated that higher conformity to the MeDi was also associated with reduced risk for AD. In a different New York population, we have also showed that higher MeDi adherence is related to a lower odds for essential tremor.
Table S1;Figure S1 ;Figure S2 from Monarch butterflies memorize the spatial location of a food source
Creators: name: Konnerth, M. Marcel
name: Foster, James J.
name: el Jundi, Basil
name: Spaethe, Johannes
name: Beetz, M. Jerome
Publisher: name: The Royal Society
Year: 2023
Subjects: classificationCode: 310901
subject: Animal behaviour

description: Temperature ranges measured for experiment 2, 3 and 4 across days. Black cells indicate rainy days where no experiments were conducted.;Performance of six individual butterflies (#133, #151, #174, #123, #134, #163) in experiment 1 (a-f) Decision rates for each feeder (F). Number of decisions are indicated (n), and the cyan bars represent the rewarded feeder.;Performance of eight individual butterflies (#180, #162, #116, #190, #191, #206, #240, #241) in experiment 2 (a-h) Decision rates for each feeder (F). Number of decisions are indicated (n), and the cyan bars represent the rewarded feeder.
Form, Fabric and Function: Ceramic Choices at Clapham's Coffeehouse, Cambridge
Creators: name: Cessford, Craig
Publisher: name: Archaeology Data Service
Year: 2023

description: Medieval Ceramics: Journal of the Medieval Ceramics Research Group, 40, 11-22
description: This paper considers vessels related to the consumption of hot beverages and alcoholic drinks which form part of an assemblage of over 500 items from Clapham's Coffeehouse, Cambridge, discarded c 1775-80. Although the assemblage has been published in detail elsewhere, there are aspects of form, fabric and decoration that have not been considered. In particular, it is proposed that traditional systems of archaeological classification, such as fabric, should be supplemented by others, which may better approximate to how vessels were perceived in the past and can perhaps lead to new insights. Two of these, explored here, are the distinctions between earth- and white-toned vessels and between 'Oriental' blue painted and plainer vessels.