cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
In vitro model based on human keratinocyte to evaluate relaxin activity on wound healing exploiting time-lapse video microscopy
Creators: name: Stellavato, Antonietta
name: Cimini, Donatella
name: Finamore, Rosario
name: Della Corte, Katia
name: Fiandra, Gilda
name: De Rosa, Mario
name: Schiraldi, Chiara
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2014
Subjects: relaxin; wound healing; time-lapse

description: Wound repair is a well-ordered but complex process involving many cellular activities including inflammation, growth factor and cytokine production, and thus cell migration and proliferation. In vitro wound healing assays have been used and are well accepted, for the discovery and validation of biomolecules that may influence cell migration and improve repair (Liu et al. 2009). The aim of our research was to exploit time-lapse video-microscopy (Okolab, Italy) to observe and analyse scratched monolayers of keratinocyte cell line (HaCat), with specific interest in characterizing different relaxin preparations.
description: Italian Journal of Anatomy and Embryology, Vol 118, No 1 (Supplement) 2013
Multidimensional optical fractionation with holographic verification
Creators: name: Xiao, Ke
name: Grier, David G.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: The trajectories of colloidal particles driven through a periodic potential energy landscape can become kinetically locked in to directions dictated by the landscape's symmetries. When the landscape is realized with forces exerted by a structured light field, the path a given particle follows has been predicted to depend exquisitely sensitively on such properties as the particle's size and refractive index These predictions, however, have not been tested experimentally. Here, we describe measurements of colloidal silica spheres' transport through arrays of holographic optical traps that use holographic video microscopy to track individual spheres' motions in three dimensions and simultaneously to measure each sphere's radius and refractive index with part-per-thousand resolution. These measurements confirm previously untested predictions for the threshold of kinetically locked-in transport, and demonstrate the ability of optical fractionation to sort colloidal spheres with part-per-thousand resolution on multiple characteristics simultaneously.
description: 4 pages, 2 figures. Accepted for publication in Physical Review Letters
Epsins in Notch skin activation
Creators: name: Di Giacomo, Giuseppina
name: Sala, Elisa
name: Ruggiero, Luca
name: Cremona, Ottavio
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2014

description: Epsins are accessory proteins for clathrin mediated endocytosis. This family consists on three members of which epsin 1 and 2 are ubiquitously expressed, while epsin 3 is mainly expressed in surface epithelia. Epsins have been related to Notch signaling (Chen et al., 2009). This pathway is involved in a broad range of processes which are fundamental for differentiation of cells derived from the three-germ layers as well as for tissue homeostasis. In skin, Notch, in concert with Shh and Wnt pathways, controls cell development and renewal, in particular regulating keratinocyte transit from basal to upper layers (Okuyama et al., 2008) Recently, we modulated the expression of epsin 1 and 3 in a human normal keratinocyte cell line – the HaCaT cells - as an initial approach to elucidate the correlation between epsin function and Notch activation in human epithelia. Silencing of epsin 1 and 3 genes by short harpin (sh) RNA technique results in downregulation of Notch signaling as assayed by scoring for the expression of some of its read-outs, including Hes1 and p21. p21 is a key factor in cell cycle arrest: decreasing p21 level determines an increase of cellular proliferation of HaCaT cell line where epsin 1 or 3 have been stably silenced. Then, we have investigated in these cell lines the expression of differentiation markers of the basal and suprabasal skin compartments. Our preliminary results in HaCaT cell line suggest a role of epsins in critically supporting Notch signaling activation during the differentiation of human keratinocytes in vitro.
description: Italian Journal of Anatomy and Embryology, Vol 118, No 2 (Supplement) 2013
title: ÐÐ±Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÐ¾Ð² ÐÐ­Ð¡ Ð½Ð° Ð¾. ÐÐ¾ÑÐ»Ð¸Ð½ Ð¸ Ð¾ÑÐµÐ½ÐºÐ° ÐµÑ Ð²Ð»Ð¸ÑÐ½Ð¸Ñ Ð½Ð° Ð¾ÐºÑÑÐ¶Ð°ÑÑÑÑ ÑÑÐµÐ´Ñ
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: Ð§ÐµÑÐºÐ°ÑÐ¾Ð², ÐÐ»Ð°Ð´Ð¸Ð¼Ð¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: Ð¾ÑÑÑÐ¾Ð² ÐÐ¾ÑÐ»Ð¸Ð½
ÐÐ­Ð£
ÐÐ­Ð¡
ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð½Ð°Ñ Ð¼Ð¾ÑÐ½Ð¾ÑÑÑ
Ð²ÐµÑÑÐ¾ÑÐ½ÐµÑÐ³ÐµÑÐ¸ÑÐµÑÐºÐ¸Ð¹ Ð¿Ð¾ÑÐµÐ½ÑÐ¸Ð°Ð»

description: Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð±ÑÐ»Ð¾ Ð¾Ð±Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð¾ ÑÐ°Ð·Ð¼ÐµÑÐµÐ½Ð¸Ðµ ÐÐ­Ð¡ Ð½Ð° Ð¾ÑÑÑÐ¾Ð²Ðµ ÐÐ¾ÑÐ»Ð¸Ð½ ÐÐµÐ½Ð¸Ð½Ð³ÑÐ°Ð´ÑÐºÐ¾Ð¹ Ð¾Ð±Ð»Ð°ÑÑÐ¸ Ñ ÑÑÐµÑÐ¾Ð¼ Ð²Ð»Ð¸ÑÐ½Ð¸Ñ ÐµÑ Ð½Ð° Ð¾ÐºÑÑÐ¶Ð°ÑÑÑÑ ÑÑÐµÐ´Ñ. ÐÑÐ¾Ð¸Ð·Ð²ÐµÐ´ÐµÐ½ ÑÐ°ÑÑÐµÑ Ð²ÐµÑÑÐ¾ÑÐ½ÐµÑÐ³ÐµÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¿Ð¾ÑÐµÐ½ÑÐ¸Ð°Ð»Ð° Ð² Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð¾Ð¼ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐµ Openwind. ÐÐ¾Ð»ÑÑÐµÐ½Ñ ÐºÐ°ÑÑÑ ÑÐ°ÑÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ñ ÑÑÐµÐ´Ð½Ð¸Ñ ÑÐºÐ¾ÑÐ¾ÑÑÐµÐ¹, ÑÐ´ÐµÐ»ÑÐ½Ð¾Ð¹ Ð¼Ð¾ÑÐ½Ð¾ÑÑÐ¸ Ð²ÐµÑÑÐ¾Ð²Ð¾Ð³Ð¾ Ð¿Ð¾ÑÐ¾ÐºÐ° Ð½Ð° Ð²ÑÑÐ¾ÑÐ°Ñ 80 Ð¸ 90 Ð¼, Ð²ÑÐ±Ð¾Ñ Ð¾Ð±ÑÑÐ»Ð¾Ð²Ð»ÐµÐ½ Ð²ÑÑÐ¾ÑÐ°Ð¼Ð¸ Ð±Ð°ÑÐµÐ½ Ð²ÐµÑÑÐ¾ÑÐ½ÐµÑÐ³ÐµÑÐ¸ÑÐµÑÐºÐ¸Ñ ÑÑÑÐ°Ð½Ð¾Ð²Ð¾Ðº. ÐÑÐ»Ð° Ð²ÑÐ±ÑÐ°Ð½Ð° ÐÐ­Ð£ ÑÐ¸ÑÐ¼Ñ Alstom ECO 110. Ð ÑÐ¾ÑÑÐ°Ð² ÐÐ­Ð¡ Ð²ÑÐ¾Ð´ÑÑ 3 ÐÐ­Ð£ ÑÑÐ¼Ð¼Ð°ÑÐ½Ð¾Ð¹ ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð½Ð¾Ð¹ Ð¼Ð¾ÑÐ½Ð¾ÑÑÑÑ 9 ÐÐÑ. ÐÑÐ¿Ð¾Ð»Ð½ÐµÐ½ ÑÐ°ÑÑÐµÑ ÑÐ²Ð°Ð¹Ð½Ð¾Ð³Ð¾ ÑÑÐ½Ð´Ð°Ð¼ÐµÐ½ÑÐ° ÐÐ­Ð£.
Multipotent stem cells in the biliary tree
Creators: name: Cardinale, Vincenzo
name: Wang, Yunfang
name: Carpino, Guido
name: Alvaro, Domenico
name: Reid, Lola
name: Gaudio, Eugenio
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2010
Subjects: stem cells; extrahepatic bile ducts; peribiliary glands; pancreas; PDX-1

description: The biliary tree system consists of two divisions: intrahepatic bile ducts and extrahepatic bile ducts. The development of the biliary tree, and secondarily the liver, shares a common origin with ventral pancreas. A common progenitor for liver, biliary duct system, and ventral pancreas exists at early stages of development, when the anterior definitive endoderm is forming the foregut. Several studies indicate that the biliary tree contains stem cell compartments for liver, pancreas and the bile duct system and persisting into adulthood. These stem cell compartments are present in the peribiliary glands and possibly give rise to committed progenitors in gallbladder that does not have peribiliary glands. The biliary tree stem/progenitors represent a new source of cells that can be used as tools for regenerative medicine of liver, bile duct and pancreas.
description: Italian Journal of Anatomy and Embryology, Vol 115, No 1/2 (2010)
Additional file 2 of Predicting immunoglobulin resistance in Kawasaki disease: an assessment of neutrophil to lymphocyte platelet ratio
Creators: name: Lu, Yuyao
name: Tang, Yunjia
name: Wang, Bo
name: Li, Xuan
name: Xu, Qiuqin
name: Chu, Hui
name: Lv, Haitao
name: Lu, Meihua
name: Qin, Yiming
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology
subject: Virology

description: Additional file 2. Comparisons of variables in patients with and without IVIG resistance. Shows the comparisons of variables in patients with and without IVIGresistance.
title: Thésaurus Covid-19
title: Covid-19 Thesaurus
Creators: name: Institut De L’information Scientifique Et Technique (Inist)-CNRS/UAR76
Publisher: name: Institut de l’information scientifique et technique (Inist) - CNRS/UAR76
Year: 2020
Subjects: subject: Science de la vie et Santé
subject: Médecine
subject: Life sciences and Health
subject: Medicine

description: Ce thésaurus bilingue(français-anglais) présente les concepts relatifs à la COVID-19, qui n’est pas sans rappeler les épidémies de syndrome respiratoire aigu sévère et de syndrome respiratoire du Moyen-Orient. Ce thésaurus est construit à partir du vocabulaire utilisé dans les publications scientifiques sur le SRAS-CoV-2 et les autres coronavirus, comme le SRAS-CoV et le MERS-CoV. Il peut être une aide à l’exploration des infections à coronavirus.
Model of the Influence of an External Magnetic Field on the Gain of Terahertz Radiation from Semiconductor Superlattices
Creators: name: Hyart, Timo
name: Mattas, Jussi
name: Alekseev, Kirill N.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We theoretically analyze the influence of magnetic field on small-signal absorption and gain in a superlattice. We predict a very large and tunable THz gain due to nonlinear cyclotron oscillations in crossed electric and magnetic fields. In contrast to Bloch gain, here the superlattice is in an electrically stable state. We also find that THz Bloch gain can be significantly enhanced with a perpendicular magnetic field. If the magnetic field is tilted with respect to the superlattice axis, the usually unstable Bloch gain profile becomes stable in the vicinity of Stark-cyclotron resonances.
description: 4 pages, replaced with final version
title: ÐÐµÐ¾ÑÐ³Ð°Ð½Ð¸ÑÐµÑÐºÐ°Ñ Ñ Ð¸Ð¼Ð¸Ñ. ÐÑÐ½Ð¾Ð²Ñ ÑÐµÐ¾ÑÐ¸Ð¸ Ñ Ð¸Ð¼Ð¸ÑÐµÑÐºÐ¸Ñ Ð¿ÑÐ¾ÑÐµÑÑÐ¾Ð²
title: ÑÑÐµÐ±Ð½Ð¾Ðµ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ðµ
titleType: Subtitle
Creators: name: ÐÑÑÐµÐ½ÐµÐ², ÐÐ¸ÑÐ°Ð¸Ð»
Publisher: name: ÐÐ·Ð´-Ð²Ð¾ ÐÐ¾Ð»Ð¸ÑÐµÑÐ½. ÑÐ½-ÑÐ°
Year: 2008
Subjects: ÐÐµÐ¾ÑÐ³Ð°Ð½Ð¸ÑÐµÑÐºÐ°Ñ Ñ Ð¸Ð¼Ð¸Ñ

description: ÐÐ¾ÑÐ¾Ð±Ð¸Ðµ ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²ÑÐµÑ Ð³Ð¾ÑÑÐ´Ð°ÑÑÑÐ²ÐµÐ½Ð½Ð¾Ð¼Ñ Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°ÑÐµÐ»ÑÐ½Ð¾Ð¼Ñ ÑÑÐ°Ð½Ð´Ð°ÑÑÑ Ð´Ð¸ÑÑÐ¸Ð¿Ð»Ð¸Ð½Ñ "Ð¥Ð¸Ð¼Ð¸Ñ" Ð¿Ð¾Ð´Ð³Ð¾ÑÐ¾Ð²ÐºÐ¸ ÑÐ¿ÐµÑÐ¸Ð°Ð»Ð¸ÑÑÐ¾Ð² Ð¿Ð¾ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ 550500 "ÐÐµÑÐ°Ð»Ð»ÑÑÐ³Ð¸Ñ". Ð Ð°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ñ Ð¾ÑÐ½Ð¾Ð²Ð¾Ð¿Ð¾Ð»Ð°Ð³Ð°ÑÑÐ¸Ðµ Ð²Ð¾Ð¿ÑÐ¾ÑÑ ÑÐ¸Ð¼Ð¸Ð¸, Ð° Ð¸Ð¼ÐµÐ½Ð½Ð¾, Ð¿ÑÐ¸ÑÐ¸Ð½Ñ Ð¿ÑÐ¾ÑÐµÐºÐ°Ð½Ð¸Ñ ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ¸Ñ ÑÐµÐ°ÐºÑÐ¸Ð¹. ÐÑÐ²ÐµÑÐµÐ½Ñ ÑÐ°ÐºÐ¸Ðµ Ð¿ÑÐ¾Ð±Ð»ÐµÐ¼Ñ, ÐºÐ°Ðº Ð´Ð²Ð¸Ð¶ÑÑÐ°Ñ ÑÐ¸Ð»Ð° ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ¾Ð¹ ÑÐµÐ°ÐºÑÐ¸Ð¸, Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ðµ ÐµÐµ Ð¿ÑÐ¾ÑÐµÐºÐ°Ð½Ð¸Ñ Ð¸ ÐºÐ¾Ð½ÐµÑÐ½ÑÐ¹ ÑÐµÐ·ÑÐ»ÑÑÐ°Ñ, Ñ. Ðµ. Ð²ÑÑÐ¾Ð´ Ð¸ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ðµ Ð¸Ð¼, ÑÐºÐ¾ÑÐ¾ÑÑÑ Ð¸ Ð¼ÐµÑÐ°Ð½Ð¸Ð·Ð¼ ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¿ÑÐµÐ²ÑÐ°ÑÐµÐ½Ð¸Ñ. ÐÑÐµÐ´Ð½Ð°Ð·Ð½Ð°ÑÐµÐ½Ð¾ Ð´Ð»Ñ ÑÑÑÐ´ÐµÐ½ÑÐ¾Ð² Ð¿ÐµÑÐ²Ð¾Ð³Ð¾ ÐºÑÑÑÐ° ÑÐ°ÐºÑÐ»ÑÑÐµÑÐ° ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ð¸ Ð¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ð¾Ð², Ð° ÑÐ°ÐºÐ¶Ðµ ÑÐ¸Ð·Ð¸ÐºÐ¾-ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¸ ÑÐ°Ð´Ð¸Ð¾ÑÐ¸Ð·Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐ°ÐºÑÐ»ÑÑÐµÑÐ¾Ð².
description: ÐÐµÑÐ°ÑÐ°ÐµÑÑÑ Ð¿Ð¾ ÑÐµÑÐµÐ½Ð¸Ñ ÑÐµÐ´Ð°ÐºÑÐ¸Ð¾Ð½Ð½Ð¾-Ð¸Ð·Ð´Ð°ÑÐµÐ»ÑÑÐºÐ¾Ð³Ð¾ ÑÐ¾Ð²ÐµÑÐ° Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¾Ð³Ð¾ Ð³Ð¾ÑÑÐ´Ð°ÑÑÑÐ²ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑÐ°.
Note on an action for a particle in the Hořava-Lifshitz Gravity
Creators: name: Eune, Myungseok
name: Kim, Wontae
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We reconsider a recently proposed action for a free particle which is compatible with Hořava-Lifshitz gravity, and then obtain the subluminal and the superluminal limits without gauge ambiguity in terms of Hamiltonian formulation.
description: 6 pages, references have been updated
Pressure-induced magnetic transition and volume collapse in FeAs superconductors: An orbital-selective Mott scenario
Creators: name: Hackl, Andreas
name: Vojta, Matthias
Publisher: name: arXiv
Year: 2008
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Motivated by pressure experiments on FeAs-122 superconductors, we propose a scenario based on local-moment physics to explain the simultaneous disappearance of magnetism, reduction of the unit cell volume, and decrease in resistivity. In this scenario, the low-pressure magnetic phase derives from Fe moments, which become screened in the paramagnetic high-pressure phase. The quantum phase transition can be described as an orbital-selective Mott transition, which is rendered first order by coupling to the lattice, in analogy to a Kondo volume collapse. Spin-fluctuation driven superconductivity competes with antiferromagnetism and may be stabilized at low temperatures in the high-pressure phase. The ideas are illustrated by a suitable mean-field analysis of an Anderson lattice model.
description: 9 pages, 3 figs; (v2) robustness of OS Mott transition vs. fragility of superconductivity discussed, final version to be published
Local re-acceleration and a modified thick target model of solar flare electrons
Creators: name: Brown, J. C.
name: Turkmani, R.
name: Kontar, E. P.
name: MacKinnon, A. L.
name: Vlahos, L.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The collisional thick target model (CTTM) of solar hard X-ray (HXR) bursts has become an almost 'Standard Model' of flare impulsive phase energy transport and radiation. However, it faces various problems in the light of recent data, particularly the high electron beam density and anisotropy it involves.} {We consider how photon yield per electron can be increased, and hence fast electron beam intensity requirements reduced, by local re-acceleration of fast electrons throughout the HXR source itself, after injection.} {We show parametrically that, if net re-acceleration rates due to e.g. waves or local current sheet electric (${\cal E}$) fields are a significant fraction of collisional loss rates, electron lifetimes, and hence the net radiative HXR output per electron can be substantially increased over the CTTM values. In this local re-acceleration thick target model (LRTTM) fast electron number requirements and anisotropy are thus reduced. One specific possible scenario involving such re-acceleration is discussed, viz, a current sheet cascade (CSC) in a randomly stressed magnetic loop.} {Combined MHD and test particle simulations show that local ${\cal E}$ fields in CSCs can efficiently accelerate electrons in the corona and and re-accelerate them after injection into the chromosphere. In this HXR source scenario, rapid synchronisation and variability of impulsive footpoint emissions can still occur since primary electron acceleration is in the high Alfvén speed corona with fast re-acceleration in chromospheric CSCs. It is also consistent with the energy-dependent time-of-flight delays in HXR features.
description: 8 pages, 2 figures
title: ÐÑÐµÐ½ÐºÐ° ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¼ÑÐ»ÑÑÐ¸Ð¼Ð¾Ð´Ð°Ð»ÑÐ½ÑÑ Ð¿ÐµÑÐµÐ²Ð¾Ð·Ð¾Ðº Ð³ÑÑÐ·Ð¾Ð²
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
Creators: name: Ð¡Ð¸Ð²Ð°ÐºÐ¾Ð², ÐÐ»Ð°Ð´Ð¸ÑÐ»Ð°Ð²
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2018
Subjects: ÐÐ¾Ð³Ð¸ÑÑÐ¸ÐºÐ°

description: ÐÐ±ÑÐµÐºÑÐ¾Ð¼ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐ²Ð»ÑÐµÑÑÑ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ñ ÑÑÐ°Ð½ÑÐ¿Ð¾ÑÑÐ½Ð¾Ð³Ð¾ Ð¿ÑÐ¾ÑÐµÑÑÐ° Ð² Ð¼ÑÐ»ÑÑÐ¸Ð¼Ð¾Ð´Ð°Ð»ÑÐ½ÑÑ Ð¿ÐµÑÐµÐ²Ð¾Ð·ÐºÐ°Ñ Ð³ÑÑÐ·Ð¾Ð².
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Handbook and guidance material for the implementation of the MOBAK App
Creators: name: Schole, Lucas
name: Lüthy, Pascale
name: Adamakis, Manolis
name: Bund, Andreas
name: Ennigkeit, Fabienne
name: Ferrari, Ilaria
name: Heim, Christopher
name: Herrmann, Christian
name: Masaryková, Dana
name: Mombarg, Remo
name: Niederkofler, Benjamin
name: Nolles, Janco
name: Vlček, Petr
name: Vrbas, Jaroslav
name: Gerlach, Erin
Publisher: name: Pädagogische Hochschule Zürich
Year: 2024
Subjects: Mobak APP
Manual
Guide
Basic motor skills
diagnostics
physical education

description: Excerpt from the introduction

«This handbook is intended to assist users of the MOBAK App (Lüthy et al., 2023) in how to use the app and what to look out for when using it.» [5]

→ for citations see bibliography in the document

→ Dutch Version: 10.5281/zenodo.10691526→ German Version: 10.5281/zenodo.10691709→ Slovak Version:  10.5281/zenodo.10691739 

 

Further documents on the MOBAK APP:

Theoretical and methodological framework for the MOBAK App. Pedagogical strategy for the use of the MOBAK App in school physical education. → 10.5281/zenodo.10691463

Teacher training toolkit supporting the implementation and the dissemination of the MOBAK App

 → 10.5281/zenodo.10691951

Method and tool to evaluate the pilot implementation of the MOBAK App → 10.5281/zenodo.10684702

Pilot implementation and evaluation study report → 10.5281/zenodo.10843490 

 

Link to the App: Mobak - App on Google Play

Suggested citation for the app:

Lüthy, P., Schole, L., Ennigkeit, F., Ferrari, I., Niederkofler, B., Gerlach, E., Adamakis, M., Bund, A., Heck, S., Heim, C., Masaryková, D., Mombarg, R., Nolles, J., Scheuer, C., Vlček, P., Vrbas, J. & Herrmann, C. 2023. MOBAK App
description: +repphzhbib2023A
TAZ Defines Breast Cancer Stem Cell Properties Downstream of Epithelial-Mesenchymal Transition and Cell Polarity
Creators: name: Cordenonsi, Michelangelo
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2011

description: Cancer Stem Cells (CSCs) are proposed to drive tumor initiation and progression. Yet, our understanding of the cellular and molecular mechanisms that underlie CSC properties is limited. Here we show that the activity of TAZ, a transducer of the Hippo pathway, is a determinant of key biological traits of breast CSCs. TAZ is required to sustain self-renewal and tumor-initiation capacities. TAZ protein levels and activity are elevated in prospective CSCs and in poorly differentiated human tumors, and have prognostic value. Gain-of-TAZ endows CSC behaviors to non-CSCs. In epithelial cells, TAZ forms a complex with the cell polarity determinant Scribble, and loss-of-Scribble - or induction of EMT - disrupt the inhibitory association of TAZ with the core Hippo kinases MST and LATS. This study links the CSC concept to the Hippo pathway in breast cancer, and reveals a mechanistic basis of the control of Hippo kinases by cell polarity.
description: Italian Journal of Anatomy and Embryology, Vol 116, No 1 (Supplement) 2011
Thermally Driven Winds from Radiatively Inefficient Accretion Flows
Creators: name: Kawabata, Ryoji
name: Mineshige, Shin
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Radiatively inefficient accretion flows (RIAFs) are common feature of low-luminosity accretion flows, including quiescent states of X-ray binaries and low-lunimosity active galactic nuclei. Thermally driven winds are expected from such hot accretion flows. By assuming that the flow has self-similarity structure in the radial direction, we solve the vertical structure of the wind and accretion flows simultaneously and evaluate the mass loss rates by wind. We find that the ratio of the outflow rate to the accretion rate is approximately unity for a viscosity parameter, alpha lesssim 0.1, despite some uncertainties in the angular momentum and temperature distributions. That is, the accretion rate in the RIAFs is roughly proportional to the radius. Moreover, we elucidate the effect of cooling by wind on the underneath accretion flow, finding that this effect could be important for calculating energy spectrum of the RIAF. Observational implications are briefly discussed in the context of Sgr A*.
description: 15 pages, 5 figures, accepted by PASJ
Microglia polarization and inflammatory challenges
Creators: name: Gemechu, Jickssa Moulissa
name: Grassi-Zucconi, Gigliola
name: Andrioli, Anna
name: Bentivoglio, Marina
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2011
Subjects: microglia; neuroinflammation; M1; M2

description: A wealth of recent evidence indicates that microglia activation is a polarized process, leading to a potentially neurotoxic M1 “classical activation” or potentially neuroprotective M2 “alternative activation”. The regulation of this process is, however, still largely unknown. We here investigated the induction of molecules which characterize M1 and M2 microglia responses after systemic (ip) and central (intracerebroventricular, icv) exposure to lipopolysaccharide (LPS). These challenges elicit different inflammatory responses of the brain parenchyma; in particular, leukocyte infiltration in the brain occurs after icv but not after ip LPS exposure. Young adult mice were subjected to ip or icv LPS injection, sacrificed at different time points from 2h up to 10 days, and compared with matched saline-treated control mice. Analyses with the pan-T cell marker CD3 confirmed the occurrence of T cells in the brain parenchyma after icv but not after ip LPS injections. Immunohistochemical phenotyping of microglia was pursued to reveal major histocompatibility complex class II (MHCII) antigen, a key molecule in M1 activation, and chitinase 3-like 3 (YM1), part of the M2 molecular repertoire. The M1 type of microglial response, revealed by upregulation of MHCII immunosignal, was very intense and occurred during the first 24h, with a peak at 2h after icv LPS, and at 6h after ip LPS. The M2 type of response, revealed by YM1 immunoreactivity in some microglial cells, followed the M1 type response evolving in the days which followed the first 24h, with an earlier peak (at 5 days) and more marked persistence (up to 10 days) after icv LPS, i.e., in the presence of T cell infiltration. Altogether the findings point out dynamic processes of microglia activation and its polarization over time, and a microglia – T cell dialogue with potential neuroprotective effects of T cell recruitment. Further investigation on the profiling of the M1 and M2 types of microglia activation, and of the possible molecules implicated in the microglia – T cell dialogue will further enlighten these crucial polarization mechanisms.
description: Italian Journal of Anatomy and Embryology, Vol 116, No 1 (Supplement) 2011
Helly-type Theorems for Hollow Axis-aligned Boxes
Creators: name: Swanepoel, Konrad J.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 52A35

description: A hollow axis-aligned box is the boundary of the cartesian product of $d$ compact intervals in R^d. We show that for d\geq 3, if any 2^d of a collection of hollow axis-aligned boxes have non-empty intersection, then the whole collection has non-empty intersection; and if any 5 of a collection of hollow axis-aligned rectangles in R^2 have non-empty intersection, then the whole collection has non-empty intersection. The values 2^d for d\geq 3 and 5 for d=2 are the best possible in general. We also characterize the collections of hollow boxes which would be counterexamples if 2^d were lowered to 2^d-1, and 5 to 4, respectively.
description: 7 pages. Old paper from 1999
A New Secular Instability of Eccentric Stellar Disks Around Supermassive Black Holes, with Application to the Galactic Center
Creators: name: Madigan, Ann-Marie
name: Levin, Yuri
name: Hopman, Clovis
Publisher: name: arXiv
Year: 2008
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We identify a new secular instability of eccentric stellar disks around supermassive black holes. We show that retrograde precession of the stellar orbits, due to the presence of a stellar cusp, induces coherent torques that amplify deviations of individual orbital eccentricities from the average, and thus drive all eccentricities away from their initial value. We investigate the instability using N-body simulations, and show that it can drive individual orbital eccentricities to significantly higher or lower values on the order of a precession time-scale. This physics is relevant for the Galactic center, where massive stars are likely to form in eccentric disks around the SgrA* black hole. We show that the observed bimodal eccentricity distribution of disk stars in the Galactic center is in good agreement with the distribution resulting from the eccentricity instability and demonstrate how the dynamical evolution of such a disk results in several of its stars acquiring high (1-e < 0.1) orbital eccentricity. Binary stars on such highly eccentric orbits would get tidally disrupted by the SgrA* black hole, possibly producing both S-stars near the black hole and high-velocity stars in the Galactic halo.
description: 5 pages, 3 figures, 1 table, submitted to ApJL. Revised version includes new figure comparing Galactic center observations to simulations and additional references
L-citrulline is protective in hyperoxic lung damage and improves matrix remodelling and alveolarization
Creators: name: Grisafi, Davide
name: Alfiero Bordigato, Michela
name: Tassone, Evelyne
name: Dedja, Arben
name: Masola, Valentina
name: Guzzardo, Vincenza
name: Artusi, Carlo
name: Porzionato, Andrea
name: Salmaso, Roberto
name: Zaninotto, Martina
name: Onisto, Maurizio
name: Milan, Anna
name: Albertin, Giovanna
name: Oselladore, Barbara
name: Macchi, Veronica
name: De Caro, Raffaele
name: Fassina, Ambrogio
name: Chiandetti, Lino
name: Filippone, Marco
name: Zaramella, Patrizia
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2011

description: Moderate hyperoxia alters alveolar and vascular lung morphogenesis. Nitric oxide (NO) and matrix metalloproteinases (MMP) have a crucial role in the homeostasis of the matrix and bronchoalveolar structure and may be regulated abnormally by exposure to hyperoxia. Disruption of vascular endothelial growth factor (VEGF)-NO signaling impairs vascular growth and contributes to hyperoxia-induced vascular disease in bronchopulmonary dysplasia (BPD). We hypothesize that L-citrulline, by raising the serum levels of L-arginine and enhancing endogenous NO synthesis, might attenuate hyperoxia-induced lung injury in an experimental model of BPD. Neonatal rats (1 day old) were exposed to 60% oxygen or room air for 14 days and administered L-citrulline or a vehicle (sham). Lung morphometry were performed; Serum was tested for arginine level; Matrix metalloproteinases2 (MMP2) gene expression, VEGF gene and protein expression and endothelial NO synthase (eNOS) protein expression were compared.  Mean linear intercept was higher in the hyperoxia and sham groups when compared with the room air (RA) and L-citr+hyperoxia treated group (p<0.02). Secondary crests number was higher in L-citrulline treated and RA when compared to hyperoxia and sham group (p<0.02). L-Arginine level rose in the L-citrulline-treated group (p<0.05). L-citrulline did not affect MMP2 gene expression, but it regulated the MMP2 active protein, which rose in bronchoalveolar lavage fluid (p<0.05), presumably due to a post-transductional effect.  Compared with RA controls, hyperoxia significantly decreased VEGF and eNOS protein expression. At the same time, an increased lung VEGF gene and protein expression (p<0.05) were also seen in the rats treated with L-citrulline. We conclude that: (i) hyperoxia decreases growth and disrupts VEGF-NO signaling of lung; (ii) the main effects of L-citrulline are an increased serum level of arginine, as a promoter and a substrate of the nitric oxide synthase; and (ii) a better alveolar growth and matrix control than in hyperoxia-induced lung damage seems promising.
description: Italian Journal of Anatomy and Embryology, Vol 116, No 1 (Supplement) 2011
title: Ð£Ð¿ÑÐ°Ð²Ð»ÐµÐ½ÑÐµÑÐºÐ°Ñ ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÐºÐ°
title: ÑÑÐµÐ±Ð½Ð¾Ðµ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ðµ
titleType: Subtitle
Creators: name: ÐÐ¸ÑÐ¸Ð³Ð¸Ð½, ÐÐ»ÐµÐ³
Publisher: name: ÐÐÐÐÐ¢ÐÐ¥-ÐÐ ÐÐ¡Ð¡
Year: 2022
Subjects: ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ðµ Ð¿ÐµÑÑÐ¾Ð½Ð°Ð»Ð¾Ð¼
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ÑÑÐµÐ±Ð½Ð¸ÐºÐ¸ Ð¸ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ñ Ð´Ð»Ñ Ð²ÑÐ·Ð¾Ð²

description: Ð£ÑÐµÐ±Ð½Ð¾Ðµ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ðµ Â«Ð£Ð¿ÑÐ°Ð²Ð»ÐµÐ½ÑÐµÑÐºÐ°Ñ ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÐºÐ°Â» ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²ÑÐµÑ Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°ÑÐµÐ»ÑÐ½Ð¾Ð¼Ñ ÑÑÐ°Ð½Ð´Ð°ÑÑÑ Ð²ÑÑÑÐµÐ³Ð¾ Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¾Ð³Ð¾ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑÐ° ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾ Ð¿Ð¾ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸ÑÐ¼ Ð¿Ð¾Ð´Ð³Ð¾ÑÐ¾Ð²ÐºÐ¸ Ð¼Ð°Ð³Ð¸ÑÑÑÐ°ÑÑÑÑ 38.04.04 Â«Ð£Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ðµ Ð¿ÐµÑÑÐ¾Ð½Ð°Ð»Ð¾Ð¼Â», 38.04.01 Â«ÐÐµÐ½ÐµÐ´Ð¶Ð¼ÐµÐ½ÑÂ», ÑÐ¿Ð¾ÑÐ¾Ð±ÑÑÐ²ÑÐµÑ ÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÑÑÑÐ¾Ð¹ÑÐ¸Ð²Ð¾Ð¹ ÑÐ²ÑÐ·Ð¸ ÑÐµÐ¾ÑÐµÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð·Ð½Ð°Ð½Ð¸Ð¹ Ñ Ð¿ÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ¸Ð¼Ð¸ Ð½Ð°Ð²ÑÐºÐ°Ð¼Ð¸. Ð ÑÑÐµÐ±Ð½Ð¾Ð¼ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ð¸ ÑÐ°ÑÑÐ¼Ð°ÑÑÐ¸Ð²Ð°ÑÑÑÑ Ð¾ÑÐ½Ð¾Ð²Ð½ÑÐµ ÐºÐ¾Ð½ÑÐµÐ¿ÑÐ¸Ð¸ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÑÑ Ð±Ð¸Ð·Ð½ÐµÑÐ° Ð¸ Ð³Ð¾ÑÑÐ´Ð°ÑÑÑÐ²Ð° Ð¿ÑÐ¸ ÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ð¸ Ð¸Ð½ÑÑÑÑÐ¼ÐµÐ½ÑÐ¾Ð² Ð¸ Ð¼ÐµÑÐ°Ð½Ð¸Ð·Ð¼Ð¾Ð² ÑÐµÐ³ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÑÐ¾ÑÐ¸Ð°Ð»ÑÐ½Ð¾-ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¸Ð¼Ð¸ Ð¿ÑÐ¾ÑÐµÑÑÐ°Ð¼Ð¸ Ð² ÑÐ¾Ð²ÑÐµÐ¼ÐµÐ½Ð½Ð¾Ð¹ ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÐºÐµ. ÐÑÐ¾Ð±Ð¾Ðµ Ð²Ð½Ð¸Ð¼Ð°Ð½Ð¸Ðµ ÑÐ´ÐµÐ»ÐµÐ½Ð¾ Ð¸Ð½ÑÑÐ¸ÑÑÑÐ¸Ð¾Ð½Ð°Ð»ÑÐ½ÑÐ¼ Ð¾ÑÐ½Ð¾Ð²Ð°Ð¼ ÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½ÑÐµÑÐºÐ¾Ð¹ ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÐºÐ¸ ÐºÐ°Ðº ÑÐ¸ÑÑÐµÐ¼Ðµ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ ÑÐµÐ»Ð¾Ð²ÐµÑÐµÑÐºÐ¸Ð¼ ÐºÐ°Ð¿Ð¸ÑÐ°Ð»Ð¾Ð¼ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¸. ÐÑÐµÐ´Ð½Ð°Ð·Ð½Ð°ÑÐµÐ½Ð¾ Ð´Ð»Ñ ÑÑÑÐ´ÐµÐ½ÑÐ¾Ð², Ð°ÑÐ¿Ð¸ÑÐ°Ð½ÑÐ¾Ð², Ð¿ÑÐµÐ¿Ð¾Ð´Ð°Ð²Ð°ÑÐµÐ»ÐµÐ¹ ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¸Ñ ÑÐ°ÐºÑÐ»ÑÑÐµÑÐ¾Ð² Ð²ÑÐ·Ð¾Ð², ÑÐ»ÑÑÐ°ÑÐµÐ»ÑÐ¼ ÐºÑÑÑÐ¾Ð² Ð¿Ð¾Ð²ÑÑÐµÐ½Ð¸Ñ Ð¿ÑÐ¾ÑÐµÑÑÐ¸Ð¾Ð½Ð°Ð»ÑÐ½Ð¾Ð¹ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¸ Ð¿Ð¾ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ Â«ÐÐµÐ½ÐµÐ´Ð¶Ð¼ÐµÐ½ÑÂ» Ð¸ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð°Ð¼ Â«Ð£Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ Ð¿ÐµÑÑÐ¾Ð½Ð°Ð»Ð¾Ð¼Â».
title: FUNCTIONALLY GRADED CONCRETE INCORPORATING RECYCLED AGGREGATES AND STEEL FIBRES: AN ENVIRONMENT-FRIENDLY OPTION FOR RIGID PAVEMENTS
Creators: name: Chan, Ricardo
Publisher: name: University of Liverpool Repository
Year: 2025

description: Fibre-reinforced recycled aggregate concrete (FRRAC) has been studied as an eco-friendly and cost-effective alternative to fibre-reinforced concrete (FRC) produced with natural aggregates. Nevertheless, FRRAC still presents some inferior properties compared to FRC, such as strength, modulus of elasticity, and durability. To overcome these issues, the concept of functionally graded material can be applied to FRRAC to produce functionally graded concretes (FGC) with enhanced properties and lesser environmental impact.
In this thesis, the proposed FGC is composed of plain cement concrete (PCC) and FRC/FRRAC in the top and bottom layers, respectively. The main topics addressed in this thesis involve the characterisation of the mechanical properties of the proposed FGC, the optimisation of the FGC using finite element method (FEM) and analytical models, and the sustainability analysis of a rigid pavement using this FGC.
The first part of the study focuses on the mechanical properties of the FGC. Standard specimens were tested under uniaxial compressive and four-point bending tests, considering different aggregates, fibre content, and the bottom layer to total thickness (h/H) ratios. Apart from that, splitting tests were used to assess the effect of different factors on the bond quality between the layers of the FGC. The test results showed that the FGC mechanical performance is inferior to FRC but superior to FRRAC. Also, the FGC studied can be produced with a casting delay shorter than 24 hours between layers without loss of mechanical performance.
Extensive 4PBTs were performed to determine the h/H ratio for the optimum post-cracking flexural performance of FGC with FRRAC. Based on the results obtained, FEM and analytical models were developed that can be used for future predictive purposes. The simulated results presented similar trends observed in the experimental results. Moreover, the optimal post-cracking flexural performance is obtained for h/H between 0.80 and 0.90.
Finally, a multi-criteria decision-making model based on the Integrated Value Model for Sustainability Assessment (MIVES) method is proposed to assess and compare the sustainability of different rigid pavement alternatives, including the proposed FGCs. The pavements were designed for the same load and evaluated from the perspective of several experts considering economic, environmental, and social aspects. The methodology to determine the sustainability index (SI) for each alternative is described while showing the importance of considering different scenarios. In this sustainability analysis, the FGC pavement received the lowest SI in the base scenario. Nevertheless, the FGC alternative is the best solution in terms of environmental aspects.
A Massive Substellar Companion to the Massive Giant HD 119445
Creators: name: Omiya, Masashi
name: Izumiura, Hideyuki
name: Han, Inwoo
name: Lee, Byeong-Cheol
name: Sato, Bun'ei
name: Kambe, Eiji
name: Kim, Kang-Min
name: Yoon, Tae Seog
name: Yoshida, Michitoshi
name: Masuda, Seiji
name: Toyota, Eri
name: Urakawa, Seitaro
name: Takada-Hidai, Masahide
Publisher: name: arXiv
Year: 2009
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We detected a brown dwarf-mass companion around the intermediate-mass giant star HD 119445 (G6III) using the Doppler technique. This discovery is the first result from a Korean-Japanese planet search program based on precise radial velocity measurements. The radial velocity of this star exhibits a periodic Keplerian variation with a period, semi-amplitude and eccentricity of 410.2 days, 413.5 m/s and 0.082, respectively. Adopting a stellar mass of 3.9 M_solar, we were able to confirm the presence of a massive substellar companion with a semimajor axis of 1.71 AU and a minimum mass of 37.6 M_Jup, which falls in the middle of the brown dwarf-mass region. This substellar companion is the most massive ever discovered within 3 AU of a central intermediate-mass star. The host star also ranks among the most massive stars with substellar companions ever detected by the Doppler technique. This result supports the current view of substellar systems that more massive substellar companions tend to exist around more massive stars, and may further constrain substellar system formation mechanisms.
description: 17 pages, 5 figures, PASJ accepted
Postgraduate eLearning satellite-based tutorials as a new approach to “teaching to teach” anatomy
Creators: name: Heyn, Rosemarie
name: Papaspyropoulos, Vassilios
name: Familiari, Giuseppe
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2011
Subjects: eLearning; teleteaching; medical education; virtual tutorials; human anatomy; innovative teaching

description: Modern educational trends approach in a more innovative, learner-centered programs that rely on a combination of interactive didactic tools and individualized tutoring. In response to the increasing need for new professionals in the health sciences who are able to apply academic eLearning in Medicine, since 2005 Sapienza University of Rome is involved in and coordinates a multidisciplinary network formed by 11 Italian universities, aimed to deliver a Master (postgraduate) course on teleteaching applied to the health sciences (Matam). This program forms highly qualified professionals for distance teaching/eLearning in health sciences and management. University sites are activated through earth and satellite-based modules, thus creating real/virtual class-rooms or didactic communities. Matam is delivered in two semesters as either synchronous satellite-based or asynchronous pre-registered tutorials (posted on an intranet site). Learners can actively and autonomously follow these modules, interacting with teachers and colleagues, whereas teachers/tutors, in turn, are in a studio at the university. The program considers a total of 60 CFU and admits a maximum of 20 participants per site. The integrated course “Multimedia technologies and virtual reality in imaging diagnostics” (8 CFU) includes 3 two-hour tutorials of human gross and microscopic anatomy (digestive and reproductive tracts), of which one is sent synchronously and two asynchronously. Matam is a sharing of knowledge, allowing teachers and learners to have a continuous and real-time update. The use of eLearning as an innovative integration within a course considering either ex cathedra and tutorial teaching may be useful for the improvement of students’ motivation and self assessment aptitudes, specially in young undergraduate ones. In addition, eLearning can favour a wider use of computer animations, thus representing a valid complement to courses particularly belonging to health sciences degrees.
description: Italian Journal of Anatomy and Embryology, Vol 116, No 1 (Supplement) 2011
title: ÐÑÐºÐ»ÑÑÐ°ÑÐµÐ»Ñ Ð¿ÐµÑÐµÐ¼ÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÐ¾ÐºÐ° Ñ ÑÐ¾ÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐ¼ Ð¾ÑÐºÐ»ÑÑÐµÐ½Ð¸ÐµÐ¼ 10ÐºÐ, 70ÐºÐ
title: Ð¼Ð°Ð³Ð¸ÑÑÐµÑÑÐºÐ°Ñ Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ñ
titleType: Subtitle
Creators: name: ÐÐ²Ð°Ð½Ð¾Ð², ÐÐ¸ÐºÐ¾Ð»Ð°Ð¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: ÐÑÐºÐ»ÑÑÐ°ÑÐµÐ»Ð¸ Ð²ÑÑÐ¾ÐºÐ¾Ð³Ð¾ Ð½Ð°Ð¿ÑÑÐ¶ÐµÐ½Ð¸Ñ
Ð¢Ð¾ÐºÐ¸ ÐºÐ¾ÑÐ¾ÑÐºÐ¾Ð³Ð¾ Ð·Ð°Ð¼ÑÐºÐ°Ð½Ð¸Ñ
ÐÐ°ÐºÑÑÐ¼Ð½Ð¾Ðµ Ð¾Ð±Ð¾ÑÑÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ
ÐÑÐ¸Ð²Ð¾Ð´Ñ
ÐÐ¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
Ð¿ÑÐ¾ÑÐµÑÑ Ð¾ÑÐºÐ»ÑÑÐµÐ½Ð¸Ñ

description: Ð ÑÐ°Ð±Ð¾ÑÐµ ÑÐ°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ñ ÑÑÑÐµÑÑÐ²ÑÑÑÐ¸Ðµ Ð¼ÐµÑÐ¾Ð´Ñ Ð¾Ð³ÑÐ°Ð½Ð¸ÑÐµÐ½Ð¸Ñ ÑÐ¾ÐºÐ¾Ð² ÐºÐ¾ÑÐ¾ÑÐºÐ¾Ð³Ð¾ Ð·Ð°Ð¼ÑÐºÐ°Ð½Ð¸Ñ Ð² ÑÐ»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ¸Ñ ÑÐµÑÑÑ, Ð¿Ð¾ÐºÐ°Ð·Ð°Ð½Ñ Ð¸Ñ Ð½ÐµÐ´Ð¾ÑÑÐ°ÑÐºÐ¸. ÐÐ¾ÐºÐ°Ð·Ð°Ð½Ð° ÑÐµÐ»ÐµÑÐ¾Ð¾Ð±ÑÐ°Ð·Ð½Ð¾ÑÑÑ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð³Ð¸Ð±ÑÐ¸Ð´Ð½ÑÑ Ð²ÑÐºÐ»ÑÑÐ°ÑÐµÐ»ÐµÐ¹ Ð¿ÐµÑÐµÐ¼ÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÐ¾ÐºÐ° Ñ ÑÐ¾ÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐ¼ Ð¾ÑÐºÐ»ÑÑÐµÐ½Ð¸ÐµÐ¼ Ð² ÑÐ»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ¸Ñ ÑÐµÑÑÑ. Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð° Ð¼Ð¾Ð´ÐµÐ»Ñ Ð²ÑÐºÐ»ÑÑÐ°ÑÐµÐ»Ñ Ð¿ÐµÑÐµÐ¼ÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÐ¾ÐºÐ° Ñ ÑÐ¾ÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐ¼ Ð¾ÑÐºÐ»ÑÑÐµÐ½Ð¸ÐµÐ¼ 10ÐºÐ, 70ÐºÐ. Ð¡Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½ Ð¿ÑÐ¾ÑÐµÑÑ Ð¾ÑÐºÐ»ÑÑÐµÐ½Ð¸Ñ ÑÐ¾ÐºÐ° ÐºÐ¾ÑÐ¾ÑÐºÐ¾Ð³Ð¾ Ð·Ð°Ð¼ÑÐºÐ°Ð½Ð¸Ñ Ð´Ð°Ð½Ð½ÑÐ¼ Ð²ÑÐºÐ»ÑÑÐ°ÑÐµÐ»ÐµÐ¼. ÐÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ñ Ð¾ÑÐ½Ð¾Ð²Ð½ÑÐµ ÐºÐ¾Ð¼Ð¿Ð¾Ð½ÐµÐ½ÑÑ Ð´Ð»Ñ Ð²ÑÐºÐ»ÑÑÐ°ÑÐµÐ»Ñ Ð¿ÐµÑÐµÐ¼ÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÐ¾ÐºÐ° Ñ ÑÐ¾ÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐ¼ Ð¾ÑÐºÐ»ÑÑÐµÐ½Ð¸ÐµÐ¼.
Stabilization, amalgamation, and curves of intersection of Heegaard splittings
Creators: name: Derby-Talbot, Ryan
Publisher: name: arXiv
Year: 2009
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 57M99

description: We address a special case of the Stabilization Problem for Heegaard splittings, establishing an upper bound on the number of stabilizations required to make a Heegaard splitting of a Haken 3-manifold isotopic to an amalgamation along an essential surface. As a consequence we show that for any positive integer $n$ there are 3-manifolds containing an essential torus and a Heegaard splitting such that the torus and splitting surface must intersect in at least $n$ simple closed curves. These give the first examples of lower bounds on the minimum number of curves of intersection between an essential surface and a Heegaard surface that are greater than one.
description: Version for publication. To appear in Algebraic and Geometric Topology
title: ÐÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ðµ ÑÑÐµÐ´Ð½ÐµÑÑÐ°ÑÐ¸ÑÑÐ¸ÑÐµÑÐºÐ¸Ñ ÐÐÐ Ð¼Ð½Ð¾Ð³Ð¾ÑÑÑÐ¿ÐµÐ½ÑÐ°ÑÑÑ ÑÐµÐ½ÑÑÐ¾Ð±ÐµÐ¶Ð½ÑÑ Ð½Ð°ÑÐ¾ÑÐ¾Ð²
title: Average efficiency calculation of multistage centrifugal pumps
Creators: name: ÐÐºÐ¸Ð¼Ð¾Ð², Ð¡ÑÐ°Ð½Ð¸ÑÐ»Ð°Ð²
name: Ð¨Ð¾ÑÐµÑ, ÐÐ°Ð²ÐµÐ»
name: "ÐÐ¸Ð´ÑÐ°Ð²Ð»Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¼Ð°ÑÐ¸Ð½Ñ, Ð³Ð¸Ð´ÑÐ¾Ð¿Ð½ÐµÐ²Ð¼Ð¾Ð¿ÑÐ¸Ð²Ð¾Ð´Ñ Ð¸ Ð³Ð¸Ð´ÑÐ¾Ð¿Ð½ÐµÐ²Ð¼Ð¾Ð°Ð²ÑÐ¾Ð¼Ð°ÑÐ¸ÐºÐ°. Ð¡Ð¾Ð²ÑÐµÐ¼ÐµÐ½Ð½Ð¾Ðµ ÑÐ¾ÑÑÐ¾ÑÐ½Ð¸Ðµ Ð¸ Ð¿ÐµÑÑÐ¿ÐµÐºÑÐ¸Ð²Ñ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ", Ð¼ÐµÐ¶Ð´ÑÐ½Ð°ÑÐ¾Ð´Ð½Ð°Ñ Ð½Ð°ÑÑÐ½Ð¾-ÑÐµÑ Ð½Ð¸ÑÐµÑÐºÐ°Ñ ÐºÐ¾Ð½ÑÐµÑÐµÐ½ÑÐ¸Ñ (2018; Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³)
Publisher: name: ÐÐ·Ð´-Ð²Ð¾ ÐÐ¾Ð»Ð¸ÑÐµÑÐ½. ÑÐ½-ÑÐ°
Year: 2018
Subjects: ÐÐ°ÑÐ¾ÑÑ ÑÐµÐ½ÑÑÐ¾Ð±ÐµÐ¶Ð½ÑÐµ

description: Ð ÑÑÐ°ÑÑÐµ Ð¿ÑÐ¸Ð²ÐµÐ´ÐµÐ½Ñ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° ÐÐÐ ÑÐµÐ½ÑÑÐ¾Ð±ÐµÐ¶Ð½ÑÑ Ð¼Ð½Ð¾Ð³Ð¾ÑÑÑÐ¿ÐµÐ½ÑÐ°ÑÑÑ Ð½Ð°ÑÐ¾ÑÐ¾Ð² Ð² ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²Ðµ 1063 ÐµÐ´Ð¸Ð½Ð¸ÑÑ 32 Ð¾ÑÐµÑÐµÑÑÐ²ÐµÐ½Ð½ÑÑ
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description: This paper presents the results of efficiency analysis of centrifugal multistage pumps in quantity 1063 units produced by 32 domestic and foreign
manufacturers. The article suggests statistical dependence of the average efficiency value on pump specific speed and single diameter.
Preliminary study on sarcoglycan sub-complex in rat cerebral and cerebellar cortex
Creators: name: Vermiglio, Giovanna
name: Runci, Michele
name: Scibilia, Antonino
name: Biasini, Fiammetta
name: Cutroneo, Giuseppina
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2012
Subjects: SMI-32; GFAP; brain; cerebellum; immunofluorescence; neurons; neuroglia

description: The sarcoglycan sub-complex is a protein system which plays a key role in sarcolemma stabilization during muscle activity. Although numerous studies have been conducted on this system, there are few data about its localization in non-muscular tissues. On this basis we carried out an indirect immunofluorescence study on normal rat cerebral and cerebellar cortex. In particular, we carried out single localization reactions to analyze if these proteins are present in brain and double localization reactions between sarcoglycans and either SMI-32 or GFAP to verify if they are expressed both in neurons and glial cells. We found that all tested sarcoglycans are present both in cerebral and cerebellar cortex and that they are expressed both in neurons and glial cells. The typical staining pattern of all sarcoglycans is represented by “spot-like” fluorescence, with spots of 0.5-2 μm average diameter laid out mainly around the soma of the cells. The main difference about sarcoglycans expression between cerebral and cerebellar cortex is that in the cerebellar cortex the sarcoglycans positivity is detectable only in an area which is likely to correspond to Purkinje cells layer. The presence of sarcoglycans in cerebral and cerebellar cortex and their disposition mainly around the soma of the cells suggest a role of these proteins in cellular signalling and in regulating postsynaptic receptor assembly mainly in axo-somatic synapses.
description: Italian Journal of Anatomy and Embryology, Vol 117, No 1 (2012)
Epsins function in Notch signaling activation
Creators: name: Di Giacomo, Giuseppina
name: Sala, Elisa
name: Ruggiero, Luca
name: Cremona, Ottavio
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2013
Subjects: Endocytosis; cell signaling; skin keratinocytes; endothelial cells

description: In mechanistic terms, endocytosis is the process by which plasma membrane (PM) components, together with extracellular solutes, macromolecules and particles, are internalized in the cell. Once the endocytic vesicle (or vacuole) is formed by fission of the PM, it is generally delivered to a specialized membrane compartment – the endosome – for recycling, degradation or re-routing. In cell-physiological terms, endocytosis exerts multiple functions, which are only partially known and characterized. At a minimum, it maintains PM homeostasis by counterbalancing the apposition of new membrane (due to exocytosis) and by renewing PM components. More extensively, endocytosis constantly modulates PM composition and takes an active part in a variety of normal and pathological cell processes, including cell nutrition, cell motility, mitosis, neurotransmission, immune response, and microorganism entry. In recent years, much of the effort to investigate this extensive endocytic activity has been focused upon unveiling the reciprocal interplay between endocytosis and cell signaling. Our laboratory, in collaboration with the laboratory of Pietro De Camilli (Yale University, USA) has pioneered the use of genetic models in mice to study several aspects of the endocytic function, mostly at the synapse. Recently, we generated mice models for a highly conserved gene family of multidomain adaptors – the epsin family - whose function was linked to endocytosis. By characterizing the phenotypic defects of the epsin1/2 double knockout mice, we found that epsins are essential components of the machinery required for Notch signaling activation during embryogenesis in mammals [1]. More recently, we characterized that epsins molecular action is exerted in a ubiquitin- dependent endocytic reaction that triggers the internalization of the Notch ligand, a process necessary for the activation of the Notch receptor. Our preliminary data extend epsin function to Notch signaling activation in primary keratinocytes and to VEGF signaling modulation in angiogenesis.
description: Italian Journal of Anatomy and Embryology, Vol 117, No 2 (Supplement) 2012
Uncertainty-principle noise in vacuum-tunneling transducers
Creators: name: Presilla, Carlo
name: Onofrio, Roberto
name: Bocko, Mark F.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The fundamental sources of noise in a vacuum-tunneling probe used as an electromechanical transducer to monitor the location of a test mass are examined using a first-quantization formalism. We show that a tunneling transducer enforces the Heisenberg uncertainty principle for the position and momentum of a test mass monitored by the transducer through the presence of two sources of noise: the shot noise of the tunneling current and the momentum fluctuations transferred by the tunneling electrons to the test mass. We analyze a number of cases including symmetric and asymmetric rectangular potential barriers and a barrier in which there is a constant electric field. Practical configurations for reaching the quantum limit in measurements of the position of macroscopic bodies with such a class of transducers are studied.