cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Code Renewability for Native Software Protection
Creators: name: Abrath, Bert
name: Coppens, Bart
name: Broeck, Jens Van den
name: Wyseur, Brecht
name: Cabutto, Alessandro
name: Falcarin, Paolo
name: De Sutter, Bjorn
Publisher: name: arXiv
Year: 2020
Subjects: subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences

description: Software protection aims at safeguarding assets embedded in software by preventing and delaying reverse engineering and tampering attacks. This paper presents an architecture and supporting tool flow to renew parts of native applications dynamically. Renewed and diversified code and data belonging to either the original application or to linked-in protections are delivered from a secure server to a client on demand. This results in frequent changes to the software components when they are under attack, thus making attacks harder. By supporting various forms of diversification and renewability, novel protection combinations become available, and existing combinations become stronger. The prototype implementation is evaluated on a number of industrial use cases.
description: 30 pages
Emissions and Radiative Impacts of Sub-10 nm Particles from Biofuel and Fossil Fuel Cookstoves
Creators: name: Shantanu H. Jathar
name: Naman Sharma
name: Bilsback, Kelsey R.
name: Pierce, Jeffrey R.
name: Vanhanen, Joonas
name: Gordon, Timothy D.
name: Volckens, John
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology

description: Combustion sources have been shown to directly emit particles smaller than 10 nm. The emission of 1-3 nm particles from biofuel or fossil-fuel cookstoves has not been studied previously, nor have the radiative impacts of these emissions been investigated. In this work, emissions (number of particles) were measured during a water boiling test performed on five different cookstoves (three-stone fire, rocket elbow, gasifier, charcoal, and liquified petroleum gas [LPG]) for particle diameters between ∼1 and ∼1000 nm. We found significant emissions of particles smaller than 10 nm for all cookstoves (>5 × 1015 # kg-fuel−1). Furthermore, cleaner (e.g., LPG) cookstoves emitted a larger fraction of sub-10 nm particles (relative to the total particle counts) than traditional cookstoves (e.g., three-stone fire). Simulations performed with the global chemical transport model GEOS-Chem-TOMAS that were informed by emissions data from this work suggested that sub-10 nm particles were unlikely to significantly influence number concentrations of particles with diameters larger than 80 nm that can serve as cloud condensation nuclei (CCN) (<0.3%, globally averaged) or alter the cloud-albedo indirect effect (absolute value <0.005 W m−2, globally averaged). The largest, but still relatively minor, localized changes in CCN-relevant concentrations (<10%) and the cloud-albedo indirect effect (absolute value <0.5 W m−2) were found in large biofuel combustion source regions (e.g., Brazil, Tanzania, Southeast Asia) and in the Southern Ocean. Enhanced coagulation-related losses of these sub-10 nm particles at sub-grid scales will tend to further reduce their impact on particle number concentrations and the aerosol indirect effect, although they might still be of relevance for human health.
CONSORT 2010 Checklist Knapp et al
Creators: name: Knapp, Peter
name: Gilbody, Simon
name: Holt, Janet
name: Keding, Ada
name: Mitchell, Natasha
name: D K Raynor
name: Silcock, Jonathan
name: Torgerson, David
Publisher: name: figshare
Year: 2020
Subjects: subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Consort trial checklist
title: Pitfalls in complement analysis: A systematic literature review of assessing complement activation
Creators: name: Brandwijk, Ricardo JMGE
name: Michels, Marloes AHM
name: van Rossum, Mara
name: de Nooijer, Aline H
name: Nilsson, Per H
name: de Bruin, Wieke CC
name: Toonen, Erik JM
Publisher: name: Philipps-Universität Marburg
Year: 2022
Subjects: complement system
literature review
immunology
Medical sciences Medicine
Medizin
complement activation

description: Background: The complement system is an essential component of our innate
defense and plays a vital role in the pathogenesis of many diseases. Assessment
of complement activation is critical in monitoring both disease progression and
response to therapy. Complement analysis requires accurate and standardized
sampling and assay procedures, which has proven to be challenging.
Objective: We performed a systematic analysis of the current methods used to
assess complement components and reviewed whether the identified studies
performed their complement measurements according to the recommended
practice regarding pre-analytical sample handling and assay technique. Results
are supplemented with own data regarding the assessment of key complement
biomarkers to illustrate the importance of accurate sampling and measuring of
complement components.
Methods: A literature search using the Pubmed/MEDLINE database was
performed focusing on studies measuring the key complement components
C3, C5 and/or their split products and/or the soluble variant of the terminal
C5b-9 complement complex (sTCC) in human blood samples that were
published between February 2017 and February 2022. The identified studies
were reviewed whether they had used the correct sample type and techniques
for their analyses.
Results: A total of 92 out of 376 studies were selected for full-text analysis.
Forty-five studies (49%) were identified as using the correct sample type and
techniques for their complement analyses, while 25 studies (27%) did not use
the correct sample type or technique. For 22 studies (24%), it was not specified
which sample type was used.
Conclusion: A substantial part of the reviewed studies did not use the
appropriate sample type for assessing complement activation or did not mention which sample type was used. This deviation from the standardized
procedure can lead to misinterpretation of complement biomarker levels and
hampers proper comparison of complement measurements between studies.
Therefore, this study underlines the necessity of general guidelines for
accurate and standardized complement analysis
title: Editorial: Updates on the complement system in kidney diseases
Creators: name: Bulla, Robert
name: Józsi, Mihály
Publisher: name: Philipps-Universität Marburg
Year: 2023
Subjects: kidney diseases
Medical sciences Medicine
Medizin
Complement system
immunology

description: The complement system is an ancient arm of the immune system. As such, it is involved in various physiological processes, including protection against pathogenic microbes and tumor cells, disposal of waste material such as dead cells and cell debris, and removal of immune complexes. In addition, several other “non-canonical” complement functions have been recognized, including roles in the activation of various cells, developmental processes, and synaptic pruning. Complement activation is potentially deleterious to the host if proceeds unchecked; thus, disturbance in the fine balance between its activation and inhibition can lead to various pathologies. The kidney is one of the organs involved in several complement-mediated diseases. This Research Topic features 13 papers covering various aspects of the role of the complement system in kidney diseases.
title: Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation
Creators: name: Papp, Alexandra
name: Papp, Krisztián
name: Uzonyi, Barbara
name: Cserhalmi, Marcell
name: Csincsi, Ádám I
name: Szábo, Zsóka
name: Bánlaki, Zsófia
name: Ermert, David
name: Prohászka, Zoltán
name: Erdei, Anna
name: Ferreira, Viviana P
name: Blom, Anna M
name: Józsi, Mihály
Publisher: name: Philipps-Universität Marburg
Year: 2022
Subjects: Extracellular Matrix
Complement System
Factor H
Medical sciences Medicine
Medizin
immunology

description: Components of the extracellular matrix (ECM), when exposed to body fluids may promote local complement activation and inflammation. Pathologic complement activation at the glomerular basement membrane and at the Bruch’s membrane is implicated in renal and eye diseases, respectively. Binding of soluble complement inhibitors to the ECM, including factor H (FH), is important to prevent excessive complement activation. Since the FH-related (FHR) proteins FHR1 and FHR5 are also implicated in these diseases, our aim was to study whether these FHRs can also bind to ECM components and affect local FH activity and complement activation. Both FH and the FHRs showed variable binding to ECM components. We identified laminin, fibromodulin, osteoadherin and PRELP as ligands of FHR1 and FHR5, and found that FHR1 bound to these ECM components through its C-terminal complement control protein (CCP) domains 4-5, whereas FHR5 bound via its middle region, CCPs 3-7. Aggrecan, biglycan and decorin did not bind FH, FHR1 and FHR5. FHR5 also bound to immobilized C3b, a model of surface-deposited C3b, via CCPs 3-7. By contrast, soluble C3, C3(H2O), and the C3 fragments C3b, iC3b and C3d bound to CCPs 8-9 of FHR5. Properdin, which was previously described to bind via CCPs 1-2 to FHR5, did not bind in its physiologically occurring serum forms in our assays. FHR1 and FHR5 inhibited the binding of FH to the identified ECM proteins in a dose-dependent manner, which resulted in reduced FH cofactor activity. Moreover, both FHR1 and FHR5 enhanced alternative complement pathway activation on immobilized ECM proteins when exposed to human serum, resulting in the increased deposition of C3-fragments, factor B and C5b-9. Thus, our results identify novel ECM ligands of FH family proteins and indicate that FHR1 and FHR5 are competitive inhibitors of FH on ECM and, when bound to these ligands, they may enhance local complement activation and promote inflammation under pathological conditions.
New Version of the AGRIS Web Portal – Overcoming the Digital Divide by Providing Rural Areas with Relevant Information
Creators: name: Simek, Pavel
name: Vanek, Jiri
name: Jarolimek, Jan
name: Stoces, Michal
name: Vogeltanzova, Tereza
name: Simek, Pavel
name: Vanek, Jiri
name: Jarolimek, Jan
name: Stoces, Michal
name: Vogeltanzova, Tereza
Publisher: name: Unknown
Year: 2011
Subjects: subject: Agribusiness
subject: Resource /Energy Economics and Policy
subject: Agris
subject: portal
subject: MVC
subject: digital divide
subject: agrarian sector
subject: rural areas
subject: information resource.

description: The present paper brings the outcomes of the second stage of a complex AGRIS web portal upgrade (technological, functional, content and design upgrade) called Agris 5.0. The Agris 5.0 version is recently being tested and will be launched in January 2012 on http://www.agris.cz. Agris 5.0 is built and runs on Microsoft technologies (MS Windows Server 2008, MS IIS 7 web server, MS SQL Server 2008 Enterprise Edition, SP2) using the Model-View-Controller (MVC) SW architectural pattern version 3, .NET framework 4, programming language C#, Razor template system, XML and XHTML 1.1 markup languages, CSS 2.1 styles and JavaScript encoding with the jQuery framework. From the user point of view, the Agris portal usability and availability meeting international standards were the utmost priority of the present upgrade.
Separable Effects for Causal Inference in the Presence of Competing Events
Creators: name: Stensrud, Mats J.
name: Young, Jessica G.
name: Didelez, Vanessa
name: Robins, James M.
name: Hernán, Miguel A.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Science Policy
subject: 60506 Virology
subject: FOS: Biological sciences

description: In time-to-event settings, the presence of competing events complicates the definition of causal effects. Here we propose the new separable effects to study the causal effect of a treatment on an event of interest. The separable direct effect is the treatment effect on the event of interest not mediated by its effect on the competing event. The separable indirect effect is the treatment effect on the event of interest only through its effect on the competing event. Similar to Robins and Richardson’s extended graphical approach for mediation analysis, the separable effects can only be identified under the assumption that the treatment can be decomposed into two distinct components that exert their effects through distinct causal pathways. Unlike existing definitions of causal effects in the presence of competing events, our estimands do not require cross-world contrasts or hypothetical interventions to prevent death. As an illustration, we apply our approach to a randomized clinical trial on estrogen therapy in individuals with prostate cancer.
Renormalizable extra-dimensional models
Creators: name: Morris, Tim R.
Publisher: name: arXiv
Year: 2004
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Non-Abelian gauge theories may have continuum limits in more than four dimensions, supported by non-trivial ultra-violet fixed points. Moreover, such theories can be expected to be accessible to Wilson's epsilon expansion. We investigate this series for SU(N) Yang-Mills, in particular for the fixed point coupling and critical exponent nu, up to four loops. From the model-building point of view, such theories would be effectively perturbatively renormalizable in the normal way. A particularly attractive possibility is the construction of renormalizable extra-dimensional models of the weak interactions, which have the potential to address the full hierarchy problem. The simplest such gauge-Higgs unification model is however ruled out by a combination of theoretical and phenomenological constraints.
description: 29 pages, 2 eps figures; extra refs added
Les benefices et les couts economiques de l'exploitation des gaz de shale au Quebec
Creators: name: Gonzalez, Patrick
name: Gonzalez, Patrick
Publisher: name: Unknown
Year: 2012
Subjects: subject: Environmental Economics and Policy
subject: Gaz de schiste
subject: analyse couts-benefices
subject: Quebec
subject: shale gas
subject: costs-benefits analysis

description: Ce texte presente une esquisse des elements quie devrait inclure une analyse couts-benefices de la pertinence de developper la filiere de l'extraction du gaz de shale au Quebec. This article offers a sketch of the components that should include a costs-benefits analysis of developing or not a shale gas industry in Quebec.
Forgotten War, Unforgotten Bodies: Locating, Repatriating, and Identifying the Remains of American Servicemen Missing in Korea, 1950-2018
Creators: name: Zhaokun Liu
Publisher: name: Carnegie Mellon University
Year: 2020
Subjects: History

description: The bodies of people who die during political purges, genocides, and wars carry multivalent political values. This dissertation argues that the remains of US servicemen lost during the Korean War had a second life amid the political strife between the United States and the DPRK after 1953. Domestically, uncertainty over the servicemen’s fate due to the loss of their remains caused their relatives to doubt the US government’s Cold War policies; internationally, the remains were associated with both the unending saber-rattling between the two countries and their concurrent attempts at cooperation. Besides their traditional roles in familial mourning and war memory, the soldiers’ remains became bargaining chips in US-DPRK relations.Utilizing archival materials, periodicals, and interviews with the relatives of missing soldiers, this dissertation analyzes the repatriation of US soldiers’ remains from the Korean Peninsula since 1950. The US military adopted a milestone policy during the Korean War—repatriating all deceased servicemen to their homeland as quickly as possible. Because of this policy and the war’s inconclusive result, it was forced to negotiate with its enemy to recover the lost bodies in areas in which it had no access and to develop new forensic methods to minimize the number of unidentifiable remains. Procedures for identification differed significantly from those in previous conflicts.While the fate of thousands of servicemen remained uncertain, some American pundits and politicians depicted them as hostages of the Communist Bloc and recruited the families of missing soldiers for their domestic and international anti-communist campaigns. A similar situation after the Vietnam War reminded Americans of the soldiers missing in Korea and established the norm that the military could only account for its missing personnel with their identified remains. The end of the Cold War created favorable conditions for recovering soldiers’ bodies from Korea, and the DPRK grasped this chance to seek maximum political and financial concessions from the United States. This study furthers our understanding of the Korean War’s legacy for Americans, the security situation in Korea, and the contribution of forensic science to the nation’s war memories.
Metodologia multicriterio aplicada a la valoracion agraria
Creators: name: Mellado, Vicente Caballer
name: Bellver, Jeronimo Aznar
name: Mellado, Vicente Caballer
name: Bellver, Jeronimo Aznar
Publisher: name: Unknown
Year: 2004
Subjects: subject: Research Methods/ Statistical Methods
subject: multicriterio
subject: alternativas
subject: criterios
subject: metodo de Kakoulaki
subject: variables explicatives
subject: ponderacion
subject: valuation
subject: agrarian valuation
subject: methods multicriteria
subject: Diakoulaki method
subject: explanatory variables
subject: weighting

description: En el presente trabajo, se revisa la relcion entre la disponibilidad de datos y los metodos de valoracion a emplear y se propone un nuevo metodo de valoracion basado en el analisis multicriterio, facil de emplear cuando se dispone de un numero reducido de datos y que un caso de valoracion se cuenta con varias posibles soluciones (distintos valores) procendentes de la utilizacion de diferentes variables explicativas. El metodo propuesto es el Metodo de Diakoulaki, con el se determina un valor final unico a partir de los distintos valores calcuados con los ratios de las distintas variables explicativas, obteniendo de esta manera un valor que esta en funcion de todas las variables y de su importancia peso o ponderacion...In this work we have revised the relationship between the availability of data and valuation methods, and we propose a new valuation method based in multicriteria analysis, easy to use in case we have a reduced number of data and it allows to solve the elecion of a final or definitive value in a rigorous way when we have different possible values coming from different explanatory variables. The proposed method is the Diakoulaki method, which allows to obtain and unique final data from different values calculated witht he ratios from different explanatory variables, the data finally obtained is function of all the variables and the weighting of them.
Identification de objetivos publicos para el apoyo al sector agrario
Creators: name: Gomez-Limon Rodriguez, Jose A.
name: Antance Muniz, Ignacio
name: Gomez-Limon Rodriguez, Jose A.
name: Antance Muniz, Ignacio
Publisher: name: Unknown
Year: 2004
Subjects: subject: Agricultural and Food Policy
subject: Politica Agraria Comin
subject: objetivos
subject: preferencias sociales
subject: AHP
subject: Castilla y Leon
subject: Common Agricultural Policy
subject: objectives
subject: social preferences
subject: Castilla y Leon.

description: La politica araria comun (PAC) resulta una politica ampliamenta debatida, tanto por su dimension (presupuesto) como por su forma de aplicacion (instrumentos empleados). Como politica al servicio de los ciudadanos, la PAC exige a sus legisladores una optima identification de los objectivos deseados por la sociedad, al igual que una adecuada elccion de los instrumentos con que afrontarlos. En este contecto, el proposito de este trabajo es analizar la importancia relative que el conjunto de la sociedad otorga a las difernetes razones que se consideran para respaldar el apoyo publico al sector agrario, y mostrar como la determinacion de los objectivos demandados por la sociedad puede ser empleada en la eleccion de los instrumentos de la PAC. Para la determincaion de las preferencias sociales se ha empleado la teenica AHP. Asimiismo, la realizacion de un analisis cluster permite observar hasta que punto los ciudadanos pueden agruparse en funcion de sus preferencias sociales en torno a la PAC. Esta metodologia se ha aplicado de forma empirica a los ciudadanos de Castilla ya LEon. La utilidad del metodo se muestra mediante su empleo en la eleccion entre diversas opcions alternativas de apoyo al sector de los cereales, oleaginosas y proteaginosas, Los resultados vienen a indicar como el proceso de decisociedad, lo cual deriva en la eleccion de politicas suboptimas para la misma...The Common Agricultural Policy (CAP) is a widely debated policy, both in reference to its budget and its instruments. To serve properly to the European citizens, CAP requires an optimal identification of the public objectives desired and an adequate election of the policy instruments to be implemented. Inside this framework, this paper aims to analyse the relative weight that citizens assign to the different possible objectives of the CAP and to show how these weights can be used for a better selection of policy instruments. Te reveal social preferences we have used to study whether citizens can be grouped according to their revealed preferences. This methodological approach has been implemented among citizens of Castilla y Leon (Spain). Finally, this methodology is applied to the selection among different alternative options to support cereal, seeds and protein crops. Results show how the current policy decision process is short of mechanisms able to identify social preferences deriving into the election of sub-optimal policies.
Tipificacion de zonas rurales a traves del analisis multivariante de informacion extraida de sistemas de informacion geografica. El caso de Tenerife
Creators: name: Godenau, Dirk
name: Hernandez Lopez, Montserrat
name: Febles Ramirez, Miguel
name: Godenau, Dirk
name: Hernandez Lopez, Montserrat
name: Febles Ramirez, Miguel
Publisher: name: Unknown
Year: 2004
Subjects: subject: Land Economics/Use
subject: Productivity Analysis
subject: Tipologia Ruarl
subject: sistemas de informacion geografica
subject: analisis multivariante
subject: Rural typology
subject: geographic information system
subject: multivariate analysis.

description: Empleando tecnicas de los Sistemas de Informacion Geografica, se asigna un conjunto de 24 variables agrarias, sociodemograficas y territoriales a las 305 Entidades de Poblacion de Tenerife. Esta informacion estadistica se somete a un analisis miltivariante con la finalidad de elaborar una tipologia de zonas. Los resultados indican la existencia de 12 tipos de zonas, 3 urbanas ya 9 rurales, cuyas diferencias se explican por la especializacion agraria y los patrones de poblamiento...Information System techniques are used to create a data base with 14 agricultural, sociodemographic and territorial variables wich are scaled down to 305 Entidades de Poblcacion in Tenerife. Multivariate analysis is applied to these data in order to construct a typology of rural zones in Tenerife. The results indicate the existence of 12 area types, 3 of which are urban and 9 rural, whose differences are based on the agricultural specialization urbanization patterns.
Truncation of stellar disks in galaxies at z~1
Creators: name: Perez, Isabel
Publisher: name: arXiv
Year: 2004
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We report here the first evidence for stellar disk truncation at high redshift, based on surface photometry of a sample of 16 high redshift (0.6 < z < 1.0) disk galaxies from the GOODS HST/ACS data. The radial profiles are best fit by a double exponential profile. This result agrees with the profile of disks in local galaxies. The cosmological surface brightness dimming at this redshift range only allows us to detect galaxies with spatially ``early'' truncation, R_br/h_in <= 3.5. Six galaxies show the radial double exponential structure, with an average value of R_br/h_in ~ 1.8. Such ``early'' truncated galaxies are missing in local samples so far. This result opens the ground for observing directly disk evolution through the study of the truncation radius as a function of redshift.
description: 4 pages, 1 figure, accepted for publication in the A&A Letters
Estimacion econometrica del valor de las cuotas lecheras:eficiencia vs tamano
Creators: name: Pinillas, Antonio Alvarez
name: Arias, Carlos
name: Gavilan, Angel
name: Pinillas, Antonio Alvarez
name: Arias, Carlos
name: Gavilan, Angel
Publisher: name: Unknown
Year: 2004
Subjects: subject: Financial Economics
subject: Livestock Production/Industries
subject: Cuotas lecheras
subject: eficiencia
subject: funcion de costes
subject: modelo econometrico
subject: milk quotas
subject: efficiency
subject: cost function
subject: econometric model.

description: En el presente trabajo se calcula el valor de la cuota para in grupo de productores lecherose en Asturias, Para ello se estima una funcion de costes variables usando datos de panel de 71 explotaciones lechuras en el periodo 1993-1998. Una caracteristica improtante del modelo empleado es que permite que los costes marginales varien con el nivel de eficienvia economica de cada explotacion. De este modo, ek valor de las cuotas para las exploraciones puede relacionarse con su eficiencia productiva...In this paper, we compute the value of production quotas for a sample of dairy farms in Asturias. For that purpose, we estimate a variable cost function with panel data of 71 dairy farms in the years 1993-1998. An important feature of the model estimated is that marginal costs depend on the economic efficiency of each farm. As a result, it is possible to explore the linkages between efficiency and quota value.
title: Complement Factor H-Related 3 Enhanced Inflammation and Complement Activation in Human RPE Cells
Creators: name: Schäfer, Nicole
name: Rasras, Anas
name: Ormenisan, Delia M
name: Amslinger, Sabine
name: Enzmann, Volker
name: Jägle, Herbert
name: Pauly, Diana
Publisher: name: Philipps-Universität Marburg
Year: 2021
Subjects: Medical sciences Medicine
Medizin
inflammation
complosome
RETC-2, RPE cells FHR-3 alters RPE cell complosome
FHR-3
oxidative stress epitopes
complement activation
AMD

description: Complement Factor H-Related 3 (FHR-3) is a major regulator of the complement system, which is associated with different diseases, such as age-related macular degeneration (AMD). However, the non-canonical local, cellular functions of FHR-3 remained poorly understood. Here, we report that FHR-3 bound to oxidative stress epitopes and competed with FH for interaction. Furthermore, FHR-3 was internalized by viable RPE cells and modulated time-dependently complement component (C3, FB) and receptor (C3aR, CR3) expression of human RPE cells. Independently of any external blood-derived proteins, complement activation products were detected. Anaphylatoxin C3a was visualized in treated cells and showed a translocation from the cytoplasm to the cell membrane after FHR-3 exposure. Subsequently, FHR-3 induced a RPE cell dependent pro-inflammatory microenvironment. Inflammasome NLRP3 activation and pro-inflammatory cytokine secretion of IL-1ß, IL-18, IL-6 and TNF-α were induced after FHR-3-RPE interaction. Our previously published monoclonal anti-FHR-3 antibody, which was chimerized to reduce immunogenicity, RETC-2-ximab, ameliorated the effect of FHR-3 on ARPE-19 cells. Our studies suggest FHR-3 as an exogenous trigger molecule for the RPE cell “complosome” and as a putative target for a therapeutic approach for associated degenerative diseases.
Elasticidad de la demanda francesa de carne de cordero de origen espanol
Creators: name: Ameur, Mehrez
name: Kaabia, Monia Ben
name: Gil, Jose M.
name: Ameur, Mehrez
name: Kaabia, Monia Ben
name: Gil, Jose M.
Publisher: name: Unknown
Year: 2004
Subjects: subject: International Relations/Trade
subject: Livestock Production/Industries
subject: Exportaciones espanolas
subject: sistemas de demanda
subject: ovino
subject: cointegracion
subject: spanish exports
subject: imports demand system
subject: lamb
subject: cointegration.

description: En este trabajo se aborda el estudio de las exporaciones espanolas de carne de ovino y caprino hacia la UE y, en particular, hacia Francia, principal destino de las mismas. El metodo utilizado se basa en la estimacion de un sistema de demanda de importaciones en el que se ha prestado especial atencion a las propiedades estadisticas de las series incluidas. La existencia de precios no estacionarios ha determinado la realizacion de un analisis previo de los mismos con el fin de determinar si estaban cointegrados y si cumplian la resticcion de homogeneidad. la aceptacion de dicha hipotesis ha permitido la especificacion de un sistema con precios relativos. Los ersultados obtenidos indican un incremento de la competitividad via precios de las exportaciones espanolas y una potencial ganancia en cuota de mercado siempre que el mercado de importanciones frances continue en expansion como ha sucedido en llos ultimos anos... The aim of the paper is to analyse the Spanish lamb exports to the EU and, particularly, to France, which is their main destination. The method used is based on the estimation of an imports demand system. The novelty of the paper relies on the explicit consideration of the stochastic characteristics of series included in the system. As prices are no stationary, cointegration among them has been tested. Results indicate that they are cointegrated and homogeneity holds. As a result, relative prices are included in the imports demand system. Results indicate an increasing price competitiveness of Spanish exports and a potential gain in market share if the French lamb imports go on growing as they have done in recent years.
title: Complement Factor H Family Proteins Modulate Monocyte and Neutrophil Granulocyte Functions
Creators: name: Kárpáti, Éva
name: Kremlitzka, Mariann
name: Sándor, Noémi
name: Jajnal, Dávid
name: Schneider, Andrea E
name: Józsi, Mihály
Publisher: name: Philipps-Universität Marburg
Year: 2021
Subjects: factor H-related protein (FHR), monocyte
neutrophil granulocyte
factor H (FH)
cytokine
complement
neutrophil extracellular trap (NET)
extracell
Medical sciences Medicine
Medizin

description: Besides being a key effector arm of innate immunity, a plethora of non-canonical functions of complement has recently been emerging. Factor H (FH), the main regulator of the alternative pathway of complement activation, has been reported to bind to various immune cells and regulate their functions, beyond its role in modulating complement activation. In this study we investigated the effect of FH, its alternative splice product FH-like protein 1 (FHL-1), the FH-related (FHR) proteins FHR-1 and FHR-5, and the recently developed artificial complement inhibitor mini-FH, on two key innate immune cells, monocytes and neutrophilic granulocytes. We found that, similar to FH, the other factor H family proteins FHL-1, FHR-1 and FHR-5, as well as the recombinant mini-FH, are able to bind to both monocytes and neutrophils. As a functional outcome, immobilized FH and FHR-1 inhibited PMA-induced NET formation, but increased the adherence and IL-8 production of neutrophils. FHL-1 increased only the adherence of the cells, while FHR-5 was ineffective in altering these functions. The adherence of monocytes was increased on FH, recombinant mini-FH and FHL-1 covered surfaces and, except for FHL-1, the same molecules also enhanced secretion of the inflammatory cytokines IL-1β and TNFα. When monocytes were stimulated with LPS in the presence of immobilized FH family proteins, FH, FHL-1 and mini-FH enhanced whereas FHR-1 and FHR-5 decreased the secretion of TNFα; FHL-1 and mini-FH also enhanced IL-10 release compared to the effect of LPS alone. Our results reveal heterogeneous effects of FH and FH family members on monocytes and neutrophils, altering key features involved in pathogen killing, and also demonstrate that FH-based complement inhibitors, such as mini-FH, may have effects beyond their function of inhibiting complement activation. Thus, our data provide new insight into the non-canonical functions of FH, FHL-1, FHR-1 and FHR-5 that might be exploited during protection against infections and in vaccine development.
title: A Family Affair: Addressing the Challenges of Factor H and the Related Proteins
Creators: name: Poppelaars, Felix
name: Goicoechea de Jorge, Elena
name: Jongerius, Ilse
name: Baeumner, Antje J
name: Steiner, Mark-Steven
name: Józsi, Mihály
name: Toonen, Erik JM
name: Pauly, Diana
Publisher: name: Philipps-Universität Marburg
Year: 2021
Subjects: factor H-like protein 1
complement system
Medical sciences Medicine
Medizin
challenges - development directions
factor H-related protein
factor H (FH)

description: Inflammation is a common denominator of diseases. The complement system, an intrinsic part of the innate immune system, is a key driver of inflammation in numerous disorders. Recently, a family of proteins has been suggested to be of vital importance in conditions characterized by complement dysregulation: the human Factor H (FH) family. This group of proteins consists of FH, Factor H-like protein 1 and five Factor H-related proteins. The FH family has been linked to infectious, vascular, eye, kidney and autoimmune diseases. In contrast to FH, the functions of the other highly homologous proteins are largely unknown and, hence, their role in the different disease-specific pathogenic mechanisms remains elusive. In this perspective review, we address the major challenges ahead in this emerging area, including 1) the controversies about the functional roles of the FH protein family, 2) the discrepancies in quantification of the FH protein family, 3) the unmet needs for validated tools and 4) limitations of animal models. Next, we also discuss the opportunities that exist for the immunology community. A strong multidisciplinary approach is required to solve these obstacles and is only possible through interdisciplinary collaboration between biologists, chemists, geneticists and physicians. We position this review in light of our own perspective, as principal investigators of the SciFiMed Consortium, a consortium aiming to create a comprehensive analytical system for the quantitative and functional assessment of the entire FH protein family.
title: Complement alternative pathway determines disease susceptibility and severity in antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis
Creators: name: Lucientes-Continente, Laura
name: Fernández-Juárez, Gema
name: Márquez-Tirado, Bárbara
name: Jímenez-Villegas, Laura
name: Acevedo, Marcedes
name: Cavero, Teresa
name: Sánchez Cámara, Luís
name: Draibe, Juliana
name: Anton-Pampols, Paula
name: Carava-Fontán, Fernando
name: Praga, Manuel
name: Villacorta, Javier
name: Goicoechea de Jorge, Elena
Publisher: name: Philipps-Universität Marburg
Year: 2023
Subjects: complement
Medical sciences Medicine
Medizin
alternative pathway
FHRs
FH
ANCA-vasculitis

description: Activation of the alternative pathway (AP) of complement is involved in the pathogenesis of antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV), although the underlying molecular mechanisms are unclear. To gain insight into the role of the AP, common gene variants in CFH/CFHR1-5, CFB, C3 and MCP, and longitudinal determinations of plasma C3, C4, FH, FHR-1, FHR-2, FHR-5, FB, properdin and sC5b-9 levels were analyzed in a Spanish AAV cohort consisting of 102 patients; 54 with active AAV (active cohort) and 48 in remission not receiving immunosuppressants or dialysis therapy (remission cohort). The validation cohort consisted of 100 patients with ANCA-associated glomerulonephritis. Here, we demonstrated that common genetic variants in complement components of the AP are associated with disease susceptibility (CFB32Q/W) or severity of kidney damage in AAV (CFH-H1, CFH1H2 and ΔCFHR3/1). Plasma levels of complement components were significantly different between active and remission cohorts. In longitudinal observations, a high degree of AP activation at diagnosis was associated with worse disease outcome, while high basal FHR-1 levels and lower FH/FHR-1 ratios determined severe forms of kidney associated AAV. These genetic and plasmatic findings were confirmed in the validation cohort. Additionally, autoantibodies against FH and C3 convertase were identified in one and five active patients, respectively. Thus, our study identified key genetic and plasma components of the AP that determine disease susceptibility, prognosis, and severity in AAV. Our data also suggests that balance between FH and FHR-1 is critical and supports FHR-1 as a novel AP-specific therapeutic target in AAV.
title: Humped surfaces : reflections on a traditional high point design for membrane lightweight structures
Creators: name: Töngi, Stephan Helmut
Publisher: name: TU Wien
Year: 2018
Subjects: subject: humped tent
subject: physical modelling
subject: digital simulation
subject: membrane simulation
subject: Contact modelling
subject: Form-finding

description: The present work is focussing on a basic category of membrane lightweight structures. The humped tents or humped surfaces. “Humping up” a fabric is one of the most elementary measures to add double curvature hence to increase pre-stress in a tensile structure like a tent, an awning or in modern terms a membrane lightweight structure. Even if not finally documented, this supporting system was presumably developed thousands of years ago by the nomadic tribes of the Middle East and has kept dominating black tent architecture until today. In the early days of Frei Ottos work, several pavilions were developed as humped tents. The humped tent henceforth should be considered as one basic form of peak tent within the whole typology of membrane lightweight structure shapes. Nonetheless the concept has sparsely been used in bigger or more recent projects. Accordingly documents are scarce and hard to find. Humped tents are an underestimated species in the field of tensile architecture. Without any doubt humped surfaces are worth a deeper exploration and merit more attention in the building industry. The aim of this research is to give the reader an overview of the subject covering the history, the nature of such structures, the architectural potential and the technical challenges. Furthermore it is the authors a key intent to introduce proprietary design strategies. Newly invented techniques and refinements for traditional formfinding i.e. physical modelling, along with specifically developed computational simulation i.e. numerical formfinding are the pivotal contributions to an improved work flow in the design of humped membrane lightweight structures. This work represents an attempt to properly examine humped surfaces in tensile architecture and close a gap in the available means of labour.
La necesidad de participacion en el diseno de nuevas politicas silvoambientales
Creators: name: Solino Millan, Mario
name: Solino Millan, Mario
Publisher: name: Unknown
Year: 2004
Subjects: subject: Agricultural and Food Policy
subject: Demand and Price Analysis
subject: Demanda de compensaciones
subject: Galicia
subject: metodo Delphi
subject: politica agro-ambiental
subject: presupuestos participativos
subject: Red Natura 2000
subject: agroenvironmental policy
subject: compensation demand
subject: Delphi method
subject: natural Network 2000
subject: participative budgets.

description: En este trabajo se fundamenta un nuevo programa silvoambiental de conservacion de paisajes forestales autoctones, basado en remunerar a los propietarios o gestores de los montes por los benficios sociales de la ampliacion y conservacion de bosques actualmente incuidos en la Red Nature 2000 en el noroeste de la Peninsula Iberica. La participacion de la poblacion en la elaboracion y diagnosticos precisos de decisiones politicas podria constituir un factor clave para el cumplimiento eficaz de los objectivos establecidos. Por ell realizamos un analisis delphi que nos ayuda a identificar cual es la mejor ordenacion y diseno de instrumentos de intervencion por parte del regulador publico y la compensacion minima que demandarian los agentes afectados por llevar a cabo medidas silvoambientales con el objectivo fundemental de conservacion y, por tanto, excluyendi el fin de produccion maderera para la obtencion de un beneficio comercia. Constatamos que este programa podria tener acomodo en la PAC, pues las cantidades demandadas se cinen al marco institucional europeo. Complementariamente se deberian disenar acciones especificas en favor de la conservaion, como por ejemply establecer una renta anual a largo plazo para valores de existencia, que se muestra como la via mas relevante...In this paper we have proposed a new forst-environmental program for conservation of autochthonous forest landscapes. The program consists in paying to woodland owners for the extension and conservation of woodlands included in the Natural Network 2000 in the north-west of the Iberian Peninsula. The participation could conform a key factor for achieving the fixed objectives. Thus, we have made a Delphi analysis that help us to identify which is the best ranking and design of instruments for the policymaker. Also, we have obtained the minimum compensation demanded by affected agents for making forest-environmental actions. We have focused our analysis in the conservation. Therefore we have excluded the timber production which main objective is the commercial benefit. We have showed that the program have accommodation in the CAP because the monetary demands adjust to the institutional European framework. Specific actions for conservation should be designed complementary. The most relevant issue should be to establish an annual long term income for existence values.
Stability of electric-field-driven MBL in an interacting long range hopping model
Creators: name: Bhakuni, Devendra Singh
name: Sharma, Auditya
Publisher: name: arXiv
Year: 2020
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: We study the fate of many-body localization (MBL) in the presence of long-range hopping ($\sim 1/r^σ$) in a system subjected to an electric field (static and time-periodic) along with a slowly-varying aperiodic potential. We show that the MBL in the static electric-field model is robust against arbitrary long-range hopping in sharp contrast to other disordered models, where MBL is killed by sufficiently long-range hopping. Next, we show that the drive-induced phenomena associated with an ac square wave electric field are also robust against long-range hopping. Specifically, we obtain drive-induced MBL, where a high-frequency drive can convert the ergodic phase into the MBL phase. Remarkably, we find that coherent destruction of MBL is also possible with the aid of a resonant drive. Thus in both the static and time-periodic square wave electric field models, the qualitative properties of the system are independent of whether the hopping is short-ranged or long-ranged.
Interaction effects in ${\bm K^+}$ photoproduction on the deuteron
Creators: name: Salam, Agus
name: Arenhoevel, Hartmuth
Publisher: name: arXiv
Year: 2004
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Kaon photoproduction on the deuteron is studied with respect to a specific two-body contribution, namely a pion mediated production process, besides other final state interaction contributions from kaon-nucleon and hyperon-nucleon scattering. In this process, a pion is first photoproduced on one nucleon and then interacts with the spectator nucleon in a strangeness exchange reaction leading to a kaon and a hyperon. A sizeable effect from this pion mediated contribution is found, considerably larger than the previously studied hyperon-nucleon rescattering, whereas kaon-nucleon rescattering is much less important. Besides total and semi-inclusive differential cross sections, tensor target asymmetries are studied with respect to the influence of such interaction effects.
description: 20 pages, 18 figures, revtex4
Ultrathin epitaxial graphite: 2D electron gas properties and a route toward graphene-based nanoelectronics
Creators: name: Berger, Claire
name: Song, Zhimin
name: Li, Tianbo
name: Li, Xuebin
name: Ogbazghi, Asmerom Y.
name: Feng, Rui
name: Dai, Zhenting
name: Marchenkov, Alexei N.
name: Conrad, Edward H.
name: First, Phillip N.
name: de Heer, Walt A.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We have produced ultrathin epitaxial graphite films which show remarkable 2D electron gas (2DEG) behavior. The films, composed of typically 3 graphene sheets, were grown by thermal decomposition on the (0001) surface of 6H-SiC, and characterized by surface-science techniques. The low-temperature conductance spans a range of localization regimes according to the structural state (square resistance 1.5 kOhm to 225 kOhm at 4 K, with positive magnetoconductance). Low resistance samples show characteristics of weak-localization in two dimensions, from which we estimate elastic and inelastic mean free paths. At low field, the Hall resistance is linear up to 4.5 T, which is well-explained by n-type carriers of density 10^{12} cm^{-2} per graphene sheet. The most highly-ordered sample exhibits Shubnikov - de Haas oscillations which correspond to nonlinearities observed in the Hall resistance, indicating a potential new quantum Hall system. We show that the high-mobility films can be patterned via conventional lithographic techniques, and we demonstrate modulation of the film conductance using a top-gate electrode. These key elements suggest electronic device applications based on nano-patterned epitaxial graphene (NPEG), with the potential for large-scale integration.
description: 5 pages, figure files: figure1.eps, figure2a.eps, figure2b.eps, figure3.eps