title: ÐÐ°Ð½Ð¾ÑÑÑÑÐºÑÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐµ Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ½ÑÐµ ÐºÐµÑÐ¸Ð¼Ð¸Ð½Ñ Ð¾ÑÐ»Ð¾ÐºÑÐ°ÑÐ¸Ð½Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ° Ð¿Ð¾ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ 16.04.01 - Ð¢ÐµÑ Ð½Ð¸ÑÐµÑÐºÐ°Ñ ÑÐ¸Ð·Ð¸ÐºÐ° ; 16.04.01_10 - ÐÐµÐ´Ð¸ÑÐ¸Ð½ÑÐºÐ°Ñ Ð±Ð¸Ð¾ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸Ñ
titleType: Subtitle
Creators: name: ÐÐ°ÑÐ¿Ð°ÑÐµÐ²Ð°, Ð¯Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2019
Subjects: Ð¾ÑÐ»Ð¾ÐºÑÐ°ÑÐ¸Ð½
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description: Ð ÐºÐ°ÑÐµÑÑÐ²Ðµ Ð¸ÑÑÐ¾Ð´Ð½ÑÑ Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ¾Ð²-Ð½Ð¾ÑÐ¸ÑÐµÐ»ÐµÐ¹ Ð´Ð»Ñ Ð¼Ð¾Ð´Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¸ Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾ÑÑÐ±ÐµÑÐºÑÐ»ÑÐ·Ð½Ð¾Ð³Ð¾ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ° Ð¾ÑÐ»Ð¾ÐºÑÐ°ÑÐ¸Ð½Ð° Ð¼ÐµÑÐ¾Ð´Ð¾Ð¼ ÑÐ°Ð´Ð¸ÐºÐ°Ð»ÑÐ½Ð¾Ð¹ ÑÐ¾Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ¸Ð·Ð°ÑÐ¸Ð¸, Ð¸Ð½Ð¸ÑÐ¸Ð¸ÑÑÐµÐ¼Ð¾Ð¹ 2,2-Ð°Ð·Ð¾-Ð±Ð¸Ñ-Ð¸Ð·Ð¾Ð±ÑÑÐ¸ÑÐ¾Ð½Ð¸ÑÑÐ¸Ð»Ð¾Ð¼, Ð¿Ð¾Ð»ÑÑÐµÐ½Ñ Ð²Ð¾Ð´Ð¾ÑÐ°ÑÑÐ²Ð¾ÑÐ¸Ð¼ÑÐµ ÑÐ¾Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÑ Ð°ÐºÑÐ¸Ð»Ð°Ð¼Ð¸Ð´Ð° (ÐÐ) Ñ Ð³Ð¸Ð´ÑÐ¾ÑÐ»Ð¾ÑÐ¸Ð´Ð¾Ð¼ 2-Ð°Ð¼Ð¸Ð½Ð¾ÑÑÐ¸Ð»Ð¼ÐµÑÐ°ÐºÑÐ¸Ð»Ð°ÑÐ° (ÐÐ¥ 2-ÐÐ­ÐÐ). ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½ ÑÐ¾ÑÑÐ°Ð², Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½ÑÐµ Ð¸ Ð³Ð¸Ð´ÑÐ¾Ð´Ð¸Ð½Ð°Ð¼Ð¸ÑÐµÑÐºÐ¸Ðµ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸ÐºÐ¸ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ ÑÐ¾Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ¾Ð². ÐÐ¾Ð´ÑÐ²ÐµÑÐ¶Ð´ÐµÐ½Ð¾ ÑÑÑÐ¾ÐµÐ½Ð¸Ðµ ÑÐ¾Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ¾Ð² ÐÐâÐÐ¥ 2-ÐÐ­ÐÐ Ð¸ Ð¸Ñ Ð¿Ð¾Ð»Ð¸ÑÐ»ÐµÐºÑÑÐ¾Ð»Ð¸ÑÐ½ÑÐµ ÑÐ²Ð¾Ð¹ÑÑÐ²Ð°. ÐÑÑÑÐ¼ Ð¸Ð¾Ð½Ð½Ð¾Ð³Ð¾ Ð¾Ð±Ð¼ÐµÐ½Ð° Ð¾ÑÑÑÐµÑÑÐ²Ð»ÑÐ½ Ð¿ÐµÑÐµÐ²Ð¾Ð´ ÑÐ¾Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ¾Ð² ÐÐ Ñ ÐÐ¥ 2-ÐÐ­ÐÐ Ð² ÑÐ¾Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÑ ÐÐâ2-ÐÐ­ÐÐ, ÑÐ¾Ð´ÐµÑÐ¶Ð°ÑÐ¸Ðµ ÑÐµÐ°ÐºÑÐ¸Ð¾Ð½Ð½Ð¾ÑÐ¿Ð¾ÑÐ¾Ð±Ð½ÑÐµ Ð¿ÐµÑÐ²Ð¸ÑÐ½ÑÐµ Ð°Ð¼Ð¸Ð½Ð¾Ð³ÑÑÐ¿Ð¿Ñ. ÐÐ¿ÑÐµÐ´ÐµÐ»ÑÐ½ ÑÐ¾ÑÑÐ°Ð² ÑÐ¾Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ¾Ð² ÐÐ Ñ 2-ÐÐ­ÐÐ. ÐÐ° Ð¾ÑÐ½Ð¾Ð²Ðµ ÑÐ¾Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ° ÐÐâ2-ÐÐ­ÐÐ Ð²Ð¿ÐµÑÐ²ÑÐµ ÑÐ¸Ð½ÑÐµÐ·Ð¸ÑÐ¾Ð²Ð°Ð½ Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ½ÑÐ¹ ÐºÐµÑÐ¸Ð¼Ð¸Ð½ Ð¾ÑÐ»Ð¾ÐºÑÐ°ÑÐ¸Ð½Ð°. ÐÑÐ¾Ð´ÑÐºÑ Ð±ÑÐ» Ð¾ÑÐ¸ÑÐµÐ½ Ð´Ð¸Ð°Ð»Ð¸Ð·Ð¾Ð¼ Ð¿ÑÐ¾ÑÐ¸Ð² Ð²Ð¾Ð´Ñ, Ð±ÑÐ»Ð¾ Ð¿Ð¾Ð´ÑÐ²ÐµÑÐ¶Ð´ÐµÐ½Ð¾ ÐµÐ³Ð¾ ÑÑÑÐ¾ÐµÐ½Ð¸Ðµ ÑÐ¿ÐµÐºÑÑÐ°Ð»ÑÐ½ÑÐ¼Ð¸ Ð¼ÐµÑÐ¾Ð´Ð°Ð¼Ð¸, ÑÐ°Ðº Ð¶Ðµ Ð±ÑÐ» ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½ ÑÐ¾ÑÑÐ°Ð². Ð Ð¼Ð¸ÐºÑÐ¾Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸ÑÑ in vitro Ð¾Ð±Ð½Ð°ÑÑÐ¶ÐµÐ½Ð¾, ÑÑÐ¾ Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ½ÑÐ¹ ÐºÐµÑÐ¸Ð¼Ð¸Ð½ Ð¾ÑÐ»Ð¾ÐºÑÐ°ÑÐ¸Ð½Ð° Ð¿ÑÐ¾ÑÐ²Ð»ÑÐµÑ Ð²ÑÑÐ¾ÐºÑÑ Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾ÑÑÐ±ÐµÑÐºÑÐ»ÑÐ½ÑÑ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ. Ð Ð¾Ð¿ÑÑÐµ Ð¿Ð¾ Ð´Ð¸Ð°Ð»Ð¸Ð·Ñ ÑÐµÑÐµÐ· Ð¿Ð¾Ð»ÑÐ¿ÑÐ¾Ð½Ð¸ÑÐ°ÐµÐ¼ÑÑ Ð¼ÐµÐ¼Ð±ÑÐ°Ð½Ñ ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð¾, ÑÑÐ¾ Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ½ÑÐ¹ ÐºÐµÑÐ¸Ð¼Ð¸Ð½ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸Ð·ÑÐµÑÑÑ Ð¿ÑÐ¾Ð»Ð¾Ð½Ð³Ð¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐ¼ Ð²ÑÐ´ÐµÐ»ÐµÐ½Ð¸ÐµÐ¼ Ð¸Ð· Ð½ÐµÐ³Ð¾ Ð¾ÑÐ»Ð¾ÐºÑÐ°ÑÐ¸Ð½Ð° Ð² Ð±ÑÑÐµÑÐµ Ñ pH 2.0 Ð¿ÑÐ¸ ÑÐµÐ¼Ð¿ÐµÑÐ°ÑÑÑÐµ 36 Â°Ð¡. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¿Ð¾Ð·Ð²Ð¾Ð»ÑÑÑ ÑÐµÐºÐ¾Ð¼ÐµÐ½Ð´Ð¾Ð²Ð°ÑÑ ÑÐ¸Ð½ÑÐµÐ·Ð¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐ¹ Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ½ÑÐ¹ ÐºÐµÑÐ¸Ð¼Ð¸Ð½ Ð¾ÑÐ»Ð¾ÐºÑÐ°ÑÐ¸Ð½Ð° Ð´Ð»Ñ ÑÐ³Ð»ÑÐ±Ð»ÑÐ½Ð½Ð¾Ð³Ð¾ Ð¼ÐµÐ´Ð¸ÐºÐ¾-Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ.
description: Water soluble acrylamide (AA) copolymers with 2-aminoethylmethacrylate hydrochloride (HCl 2-AEMA) were obtained as carrier polymers precursor for modification of the anti-tuberculosis drug ofloxacin. They were synthesized by the method of radical copolymerization initiated by 2,2-azo-bis-isobutyronitrile. The composition, molecular and hydrodynamic characteristics of the copolymers obtained were investigated. The structure of the AAâHCl 2-AEMA copolymers and their polyelectrolyte properties were confirmed. AA copolymers with HCl 2-AEMA were converted into AAâ2-AEMA copolymers (which contain reactive primary amino groups) by ion exchange. The composition of AA copolymers with 2-AEMA was determined. Based on the AAâ2-AEMA copolymer, the polymeric ketimine of ofloxacin was firstly synthesized. The product was purified by dialysis against water, its structure was confirmed by spectral methods, the composition was also established. As a result of in vitro microbiological studies, it was found that the ketimine ofloxacin polymer exhibits high anti-tuberculosis activity. The experiment of dialysis through a semipermeable membrane exhibited that the polymeric ketimine is characterized by a prolonged release of ofloxacin from it in a buffer with pH 2.0 at a temperature of 36 Â° C. The results obtained allow us to recommend the synthesized polymeric ketimine of ofloxacin for in-depth medical and biological study.