cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Canada's Pioneering Experience with a Flexible Exchange Rate in the 1950s: (Hard) Lessons Learned for Monetary Policy in a Small Open Economy
Creators: name: Bordo, Michael
name: Dib, Ali
name: Schembri, Lawrence L.
Publisher: name: Bank of Canada
Year: 2007

description: This paper revisits Canada's pioneering experience with floating exchange rate over the period 1950–1962. It examines whether the floating rate was the best option for Canada in the 1950s by developing and estimating a New Keynesian small open economy model of the Canadian economy. The model is then used to conduct a counterfactual analysis of the impact of different monetary policies and exchange rate regimes. The main finding indicates that the flexible exchange rate helped reduce the volatility of key macroeconomic variables. The Canadian monetary authorities, however, clearly did not understand all of the implications of conducting monetary policy under a flexible exchange rate and a high degree of capital mobility. The paper confirms that monetary policy was more volatile in the post-1957 period and Canada's macroeconomic performance suffered as a result.
description: Les auteurs réexaminent l'expérience novatrice à laquelle le Canada s'est livré de 1950 à 1962 en laissant flotter sa monnaie. En vue de déterminer si le régime de changes flottants offrait la meilleure solution au Canada des années 1950, ils construisent et estiment un nouveau modèle keynésien de petite économie ouverte représentatif de l'économie canadienne. À l'aide de ce modèle, ils procèdent à une analyse contrefactuelle des effets de plusieurs politiques monétaires et régimes de change. Leurs résultats révèlent que le taux de change flottant permit de réduire la volatilité de variables macroéconomiques clés. Cependant, les autorités monétaires de l'époque ne saisissaient pas, de toute évidence, l'ensemble des implications qu'avaient un régime de changes flottants et un haut degré de mobilité des capitaux sur la conduite de la politique monétaire. Le travail des auteurs confirme que la politique monétaire fut moins stable après 1957 et que la situation macroéconomique du Canada s'en trouva dégradée.
Hybrid Steel-Glass Cell: Cold-twisting and Buckling Phenomena
Creators: name: Galuppi, Laura
name: Di Biase, Pietro
name: Schaaf, Benjamin
name: Richter, Carl
name: Hoffmeister, Benno
name: Feldmann, Markus
name: Royer Carfagni, Gianni
Publisher: name: Challenging Glass Conference Proceedings
Year: 2018

description: The European RFCS project “S+G” has developed innovative steel-glass composite systems for high-performance building skins, meeting requirements of structural and energetic efficiency, as well as aesthetical value and versatility of applications. The aim of the project has been the design, prototype and testing of unitized cells composed by a glass panel and a contouring metallic frame, twisted by cold bending into a hyperbolic paraboloid shape, to be used in free-form curved building façades. To achieve large curvatures while maintaining the stress under the limit strength, very thin glass needs to be used, with a consequent risk of loss of stability. Preliminary investigations have been conducted to evaluate the buckling load in the glass panel and the possible stiffening effect of the contouring metallic frame. Then, accurate FE analyses, accounting for geometric and material nonlinearities, have been used to optimize the design of the unitized cell. Finally, two-steps experimental tests have been performed on full-scale samples. First, the prototypes are cold-twisted, maintaining limited the displacement of the corners, so to avoid buckling. Secondly, out-of-plane loading is applied to simulate wind, snow or man load. Thanks to the curvature, the cells showed very high strength due to the synergetic coupling of steel and glass. Here, we present the experimental and numerical investigations and the main results from full-scale tests. These have been used to refine the FE model, in order to investigate the role of both the interlayer and of the steel-to-glass bonding, and to develop a simplified model for practical design applications.
description: Challenging Glass Conference Proceedings, Vol. 6 (2018): Challenging Glass 6
MOESM1 of Drug screening approach combines epigenetic sensitization with immunochemotherapy in cancer
Creators: name: Facciotto, Chiara
name: Casado, Julia
name: Turunen, Laura
name: Suvi-Katri Leivonen
name: Tumiati, Manuela
name: Rantanen, Ville
name: Kauppi, Liisa
name: Lehtonen, Rainer
name: LeppÃ¤, Sirpa
name: Wennerberg, Krister
name: Hautaniemi, Sampsa
Publisher: name: figshare
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Additional file 1. Supplementary file containing additional methods and results, as well as the user guide for the Results Explorer.
Additional file 2 of The critical role of dysregulated Hh-FOXM1-TPX2 signaling in human hepatocellular carcinoma cell proliferation
Creators: name: Wang, Yiting
name: Wang, Hailong
name: Yan, Zhengwei
name: Li, Guohua
name: Hu, Guohui
name: Zhang, Hong
name: Huang, Dengliang
name: Wang, Yao
name: Zhang, Xiang
name: Yan, Yehong
name: Lu, Quqin
name: Cheng, Minzhang
name: Luo, Shiwen
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2: Table S1. Target sequences of gene-silencing constructs. Table S2. Primers for Real-time PCR amplification. Table S3. Primer sequences for TPX2-Luciferase reporter constructs. Table S4. Primer for ChIP.
Energy-based Graph Convolutional Networks for Scoring Protein Docking Models
Creators: name: Cao, Yue
name: Shen, Yang
Publisher: name: arXiv
Year: 2019
Subjects: subject: Biomolecules (q-bio.BM)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Machine Learning (cs.LG)
subject: FOS: Biological sciences
subject: FOS: Computer and information sciences

description: Structural information about protein-protein interactions, often missing at the interactome scale, is important for mechanistic understanding of cells and rational discovery of therapeutics. Protein docking provides a computational alternative to predict such information. However, ranking near-native docked models high among a large number of candidates, often known as the scoring problem, remains a critical challenge. Moreover, estimating model quality, also known as the quality assessment problem, is rarely addressed in protein docking. In this study the two challenging problems in protein docking are regarded as relative and absolute scoring, respectively, and addressed in one physics-inspired deep learning framework. We represent proteins' and encounter complexes' 3D structures as intra- and inter-molecular residue contact graphs with atom-resolution node and edge features. And we propose a novel graph convolutional kernel that pool interacting nodes' features through edge features so that generalized interaction energies can be learned directly from graph data. The resulting energy-based graph convolutional networks (EGCN) with multi-head attention are trained to predict intra- and inter-molecular energies, binding affinities, and quality measures (interface RMSD) for encounter complexes. Compared to a state-of-the-art scoring function for model ranking, EGCN has significantly improved ranking for a CAPRI test set involving homology docking; and is comparable for Score_set, a CAPRI benchmark set generated by diverse community-wide docking protocols not known to training data. For Score_set quality assessment, EGCN shows about 27% improvement to our previous efforts. Directly learning from 3D structure data in graph representation, EGCN represents the first successful development of graph convolutional networks for protein docking.
Australeon illustris Miller & Stange 2012, new combination
Creators: name: Miller, Robert B.
name: Stange, Lionel A.
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Neuroptera
Myrmeleontidae
Australeon
Australeon illustris

description: Australeon illustris (Gerstaecker), new combination
(Figures 66, 67, 68, 97, 98)
 Myrmeleon illustris Gerstaecker 1885: 92. Holotype, Sydney (EMAU).
 Taxonomy: Esben-Petersen 1915: 6 2 (in Callistoleon). Further description: Gerstaecker 1888: 111; New 1985a: 9, figures 42-50 (wings; male, female terminalia, male genitalia); New and Matsura 1993: 95, figures 10-19 (wings; male, female terminalia; male genitalia; spermatheca).
 Description. Adult: body length 30 to 33 mm, forewing length 30 to 33 mm, hindwing length 26 to 30 mm. Coloration: general coloration dark brown; palpi, labrum and clypeus tawny; clypeus sometimes slightly darkened posteriorly; frons dark brown to black; vertex dark brown, unmarked; antennae black, dorsal side of scape partly tawny; pronotum tawny orange, sometimes darkened medially; pterothorax and abdomen black; wing venation generally pale brown except where shaded, but with anterior longitudinal veins brown; markings variable, mostly grayish brown; apical hind margin fumose; forefemur tawny except apex, midfemur and hindfemur dark brown; tibia and tarsomere dark brown. Chaetotaxy: pronotum with mostly black setae; femur and tibia with few black bristles; female ectoproct with about 6 to 10 long thickened setae; lateral gonapophysis with dense thickened setae toward apex, shorter than gonapophysis; anterior gonapophysis with black setae. Structure: antenna slender, club gradually broadened; vertex domed; pronotum broader than long; wings slender and tapered; distal tarsomere longer than basitarsus; tibial spurs somewhat curved, extending almost to apex of tarsomere II; pretarsal claws about equal to tibial spurs; female ectoproct with distinct ventral lobe; lateral gonapophysis very broad; posterior gonapophysis long and slender; anterior gonapophysis broad; spermatheca small, coiled; male ectoproct broad, sternite IX tapered to narrow apex; gonarcus very broad and shallow, mediuncus broad and deep; parameres parallel, heavily sclerotized along inner edge and at apex, with strong dorsal flange anteriorly.
 Distribution. New South Wales.
 New record. AUSTRALIA. New South Wales: Pilliga Nature Reserve, 34 km. north Coonobarabran, New South Wales, 3.XII.1989, R. Miller (reared) (1m, 1f, l larva, FSCA).
 Discussion. Australeon illustris is very close morphologically to A. manselli but has more slender wings which are more infumate posteriorly and also has genitalic differences. It differs notably in coloration having the anterior margin of the frons dark brown in contrast to the pale yellow anterior margin of the frons in A. manselli.
description: Published as part of Miller, Robert B. & Stange, Lionel A., 2012, The cave mouth antlions of Australia (Neuroptera: Myrmeleontidae), pp. 1-65 in Insecta Mundi 2012 (250) on page 41, DOI: 10.5281/zenodo.5174820
title: Endogenously Segmented Asset Market in an Inventory Theoretic Model of Money Demand
Creators: name: Chiu, Jonathan
Publisher: name: Bank of Canada
Year: 2007

description: This paper studies the effects of monetary policy in an inventory theoretic model of money demand. In this model, agents keep inventories of money, despite the fact that money is dominated in rate of return by interest bearing assets, because they must pay a fixed cost to transfer funds between the asset market and the goods market. Unlike the exogenous segmentation models in the literature, the timings of money transfers are endogenous. By allowing agents to choose the timings of money transfers, the model endogenizes the degree of market segmentation as well as the magnitude of liquidity effects, price sluggishness and variability of velocity. First, I show that the endogenous segmentation model can generate the positive long run relationship between money growth and velocity in the data which the exogenous segmentation model fails to capture. Second, I show that the short run effects of money shocks in an exogenous segmentation model (such as the linear inflation response to money shock, the liquidity effect and the sluggish price adjustment) are not robust. In an endogenous segmentation model, the equilibrium response to money shocks is non-linear and non-monotonic. Moreover, for large money shocks, there is no liquidity effect and no sluggish price adjustment.
description: L'auteur examine les effets de la politique monétaire à l'aide d'un modèle de demande de monnaie inspiré de la théorie de la gestion des stocks. Même si les actifs rémunérés offrent un meilleur taux de rendement que la monnaie, les agents conservent des stocks de monnaie, car les transferts de fonds entre marché financier et marché des biens sont soumis à un coût fixe. Prenant le contrepied des modèles avec segmentation exogène présentés dans la littérature, l'auteur permet aux agents de décider eux-mêmes du moment des transferts. Il fait ainsi du degré de segmentation des marchés une donnée endogène de son modèle, au même titre que l'ampleur des effets de liquidité, la lenteur de l'ajustement des prix et la variabilité de la vitesse de circulation de la monnaie. L'auteur montre d'abord que, contrairement au modèle avec segmentation exogène, son modèle avec segmentation endogène parvient à reproduire la relation positive qui lie à long terme la croissance et la vitesse de circulation de la monnaie d'après les données. Il montre ensuite que les répercussions (réaction linéaire de l'inflation, effet de liquidité, rigidité dans l'ajustement des prix) entraînées à court terme par les chocs monétaires dans les modèles avec segmentation exogène ne sont pas robustes. Dans le modèle avec segmentation endogène, les valeurs d'équilibre réagissent aux chocs monétaires de façon non linéaire et non monotone. De plus, lorsque ces chocs sont importants, on n'observe aucun effet de liquidité et les prix s'ajustent rapidement.
title: Implications of Asymmetry Risk for Portfolio Analysis and Asset Pricing
Creators: name: Chabi-Yo, Fousseni
name: Leisen, Dietmar
name: Renault, Eric
Publisher: name: Bank of Canada
Year: 2007

description: Asymmetric shocks are common in markets; securities' payoffs are not normally distributed and exhibit skewness. This paper studies the portfolio holdings of heterogeneous agents with preferences over mean, variance and skewness, and derives equilibrium prices. A three funds separation theorem holds, adding a skewness portfolio to the market portfolio; the pricing kernel depends linearly only on the market return and its squared value. Our analysis extends Harvey and Siddique's (2000) conditional mean-variance-skewness asset pricing model to non-vanishing risk-neutral market variance. The empirical relevance of this extension is documented in the context of the asymmetric GARCH-in-mean model of Bekaert and Liu (2004).
description: Les chocs asymétriques sont des phénomènes courants sur les marchés. La distribution des rendements des actifs financiers ne suit pas une loi normale et est asymétrique. Les auteurs étudient la composition du portefeuille d'agents hétérogènes qui ont des préférences à l'égard de la moyenne, de la variance et de l'asymétrie de la distribution des rendements, et calculent les prix d'équilibre des actifs. Ils démontrent la validité d'un théorème de séparation à trois portefeuilles, selon lequel les agents détiennent un portefeuille dont les rendements sont répartis de façon asymétrique en plus du portefeuille standard du marché; le facteur d'actualisation stochastique ne dépend linéairement que du rendement du marché et du carré de celui-ci. Les auteurs étendent le modèle d'évaluation des actifs financiers à trois moments conditionnels (moyenne, variance et asymétrie) de Harvey et Siddique (2000) pour y inclure une variance du rendement du marché neutre à l'égard du risque et toujours supérieure à zéro. Ils testent empiriquement la pertinence de cette extension au moyen du modèle GARCH-M asymétrique de Bekaert et Liu (2004).
Additional file 1 of Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer
Creators: name: Lin, Feikai
name: Li, Xiaoduan
name: Wang, Xinjing
name: Sun, Huizhen
name: Wang, Ziliang
name: Wang, Xipeng
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Cancer
subject: Computational Biology

description: Additional file 1.
Theoretical isochrones for the Delta a photometric system
Creators: name: Claret, A.
name: Paunzen, E.
name: Maitzen, H. M.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We have calculated theoretical isochrones for the photometric Delta a system to derive astrophysical parameters such as the age, reddening and distance modulus for open clusters. The Delta a system samples the flux depression at 520 nm which is highly efficient to detect chemically peculiar (CP) objects of the upper main sequence. The evolutionary status of CP stars is still a matter of debate and very important to test, for example, the dynamo and diffusion theories. In fact, the dynamo or fossil origin of the magnetic fields present in this kind of stars it still not clear. Using the stellar evolutionary models by Claret (1995), a grid of isochrones with different initial chemical compositions for the Delta a system was generated. The published data of 23 open clusters were used to fit these isochrones with astrophysical parameters (age, reddening and distance modulus) from the literature. As an additional test, isochrones with the same parameters for Johnson UBV data of these open clusters were also considered. The fits show a good agreement between the observations and the theoretical grid. We find that the accuracy of fitting isochrones to Delta a data without the knowledge of the cluster parameters is between 5 and 15%.
description: 5 pages, 4 figures, accepted by A&A
MOESM3 of Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer’s disease related pathology
Creators: name: Joshi, Amit
name: Wassenhove, Lauren
name: Logas, Kelsey
name: Paras Minhas
name: Andreasson, Katrin
name: Weinberg, Kenneth
name: Che-Hong Chen
name: Mochly-Rosen, Daria
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Biotechnology
subject: Hematology

description: Additional file 3: Figure S3. ALDH2 plays a critical role in regulating cell health in Alzheimer’s disease patient fibroblast. a) Measurement of mitochondrial ROS using MitoSOX™ in 4 control and 4 AD patient-derived fibroblasts in the presence or absence of Alda-1 (20 μM/48 h; 50 mM Ethanol). b) 4-HNE levels were measured using 4-HNE Assay Kit in control and AD patient-derived fibroblasts in the presence or absence of Alda-1 (20 μM/48 h; 50 mM Ethanol). c) Cellular ATP levels were analyzed using CellTiter-Glo Luminescent Cell Viability kit in control and AD patient-derived fibroblasts in the presence or absence of Alda-1 (20 μM/36 h; 50 mM Ethanol). d) Cellular ROS production was measured using 2,7 dichloro- fluorescein diacetate (DCFDA) in control and AD patient-derived fibroblasts in the presence or absence of Alda-1 (20 μM/48 h; 50 mM Ethanol). Data information: Mean, standard deviation, and p-values are shown. Results are presented as fold change. n = 3–7 independent biological replicates; probability by one-way ANOVA (with Holm-Sidak post hoc test).
Research on Thin Glass-Polycarbonate Composite Panels
Creators: name: Weimar, Thorsten
name: Andrés López, Sebastián
Publisher: name: Challenging Glass Conference Proceedings
Year: 2018

description: Glass, particularly in architectural design, expresses lightness and modernity. By rising glass surfaces of facades in buildings with high safety requirements, glass works as security glazing. Requirements of security glazing increase constantly. However, single glass panes do not fulfil the demands on these high technology products. Thereby, laminated glass or insulated glass are used to solve problems of the specifications in view of fire, heat, noise, sound and sun protection as well as safety, energy, design or media. The combination of different materials in a composite panel permits the optimisation in consideration of requested structural or mechanical properties. In this case, the lamination of brittle glass with ductile polycarbonate enables innovative composite panels, which extends the range of glazing with security relevant applications. Glass-polycarbonate composite panels are generally defined with two outer glass panes and one or more inner polycarbonate sheets, laminated with polymeric interlayers. The combination of these two materials demonstrates a more efficient alternative to common security glazing. Continuous developments in the field of thin glass result in more and more applications beyond the usage in smartphones or tablets. Large-sized thin glasses with a nominal thickness of 2 mm or less are for some time available and already used in science and technology. Applications of thin glass in the building sector demand to analyse the required material properties and to combine thin glass panes with additional layers due to its low geometrical stiffness. An option for applications of large-sized thin glass panes presents the lamination with polycarbonate. Thin glass substitute the two outer glass panes in glass-polycarbonate composite panels. Therefore, thin glass-polycarbonate composite panels are slighter than common security glazing. Several options for using thin glass in architecture and the lamination with polycarbonate are described as well as the required tests for using as laminated safety glass and security glass with resistance against manual attack.
description: Challenging Glass Conference Proceedings, Vol. 6 (2018): Challenging Glass 6
title: Estimating and Comparing the Implied Cost of Equity for Canadian and U.S. Firms
Creators: name: Witmer, Jonathan
name: Zorn, Lorie
Publisher: name: Bank of Canada
Year: 2007

description: This paper estimates the implied cost of equity for Canadian and U.S. firms using a methodology based on the dividend discount model and utilizing firms' current stock price and analysts' forecasted earnings. We find that firm size and firm stock liquidity are negatively related to cost of equity, while greater firm financial leverage and greater dispersion in analysts' earnings forecasts are associated with a higher cost of equity. Moreover, longer-term sovereign bond yields also seem to play a role in a firm's cost of equity. After controlling for several factors, both at a firm-level and at an aggregate level, we find that the cost of equity for Canadian firms is 30-50 bps higher than that of U.S. firms during 1988-2006. Because our estimates may not fully account for factors such as currency risk, inflation uncertainty, degree of market integration, personal taxes, and differences in regulatory environments, we might shed further light on these results by incorporating proxies for these factors and perhaps extending our comparison to more countries.
description: En faisant appel à une méthodologie basée sur le modèle d'actualisation des dividendes et en exploitant des données relatives au prix actuel des actions et aux bénéfices anticipés par les analystes, les auteurs estiment le coût implicite des capitaux propres des firmes canadiennes et américaines. Ils constatent que la taille des sociétés et la liquidité des actions varient en sens inverse du coût des capitaux propres, alors que l'ampleur de l'endettement des entreprises et de la dispersion des prévisions de profits émanant des analystes est en relation positive avec des coûts élevés. Il semble, en outre, que les rendements des obligations d'État à long terme aient une incidence au chapitre du coût des fonds propres. Après avoir pris en compte plusieurs facteurs à l'échelle des entreprises individuelles aussi bien qu'au niveau agrégé, les auteurs concluent que le coût des capitaux propres des firmes canadiennes dépasse de 30 à 50 points de base celui supporté par les entreprises américaines entre 1988 et 2006. Comme l'étude peut ne pas tenir pleinement compte de facteurs tels que le risque de change, l'incertitude liée à l'inflation, le degré d'intégration des marchés, l'impôt des particuliers et les différences entre les cadres réglementaires, il pourrait s'avérer utile d'incorporer des variables d'approximation à l'égard de ces facteurs et, peut-être, d'étendre la comparaison à d'autres pays.
Kansas Farmers Interest and Preferences for Growing Cellulosic Bioenergy Crops
Creators: name: Fewell, Jason
name: Lynes, Melissa
name: Williams, Jeffery
name: Bergtold, Jason
name: Fewell, Jason
name: Lynes, Melissa
name: Williams, Jeffery
name: Bergtold, Jason
Publisher: name: Unknown
Year: 2013
Subjects: subject: Resource /Energy Economics and Policy
subject: cellulosic bioenergy crops
subject: biofuel
subject: bioenergy
subject: biomass

description: A survey was administered to determine Kansas farmers’ willingness to grow crops for biofuel. The primary purpose of the survey was to assess farmers’ willingness to produce biomass for cellulosic bioenergy in the forms of a value added crop, an annual energy crop, and a perennial energy crop under a favorable contractual arrangement, as well as to determine reasons they would or would not grow a bioenergy crop under a contract. Results show that net returns and contract length were the most important characteristics influencing farmers’ willingness to produce cellulosic bioenergy crops.
Additional file 6: of Genome-scale CRISPR-Cas9 knockout screening in gastrointestinal stromal tumor with Imatinib resistance
Creators: name: Cao, Jie
name: Wei, Jianchang
name: Yang, Ping
name: Zhang, Tong
name: Chen, Zhuanpeng
name: He, Feng
name: Wei, Fang
name: Chen, Huacui
name: Hu, He
name: Zhong, Junbin
name: Yang, Zhi
name: Cai, Wensong
name: Li, Wanglin
name: Wang, Qiang
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: Plant Biology

description: Table S4. Candidate genesmiRNAs with sgRNA sequence, total reads and diversity. (DOCX 13Â kb)
Exploring Thin Glass Strength Test Methodologies
Creators: name: Oliveira Santos, Francisco
name: Louter, Christian
name: Correia, João Ramôa
Publisher: name: Challenging Glass Conference Proceedings
Year: 2018

description: Thin glass is currently widespread in mobile devices and has great potential for applications in buildings. However, presently there is no standard method to determine the strength of thin glass for building applications and there is little experimental data available on its mechanical behaviour. Hence, this paper presents experimental and numerical investigations developed with two main goals: (i) to assess and (eventually) adapt existing test setups in order to determine the strength of thin glass; and (ii) to characterize thin glass using those tests, focusing on the ultimate strength of the material. The experimental programme, which was executed at TU Delft, comprised destructive tests on chemically tempered thin glass (thickness of 2 mm). Two destructive tests were assessed and tentatively improved: the in-plane four-point bending test, which involved many difficulties related with geometrical and mechanical instabilities; and the buckling test, which provided a lower bound for the material strength, as failure was triggered in the supports (due to stress concentrations). Based on the results obtained, a new tension test was proposed and numerically investigated; the results obtained revealed many advantages over the former tests in terms of quality/consistency of results and possibility of standardization.
description: Challenging Glass Conference Proceedings, Vol. 6 (2018): Challenging Glass 6
Spot Landing: Determining the Light and Solar Properties of Fritted and Coated Glass
Creators: name: Wilson, Helen Rose
name: Elstner, Michael
Publisher: name: Challenging Glass Conference Proceedings
Year: 2018

description: The use of ceramic fritted architectural glazing is becoming increasingly popular. “Fritted glass”, which is also known as “enamelled glass”, is defined as glass with a surface covering made of glass frit[1] that is applied by a printing method and fused to the glass substrate at elevated temperatures. The enamel coating may be continuous or consist of a discontinuous pattern such as spots or stripes. Functional thin-film coatings on glass have been used in standard glazing units for many years to improve thermal insulation or for solar control. Specification of light and solar properties for these standard glazing types is well-defined and can be calculated on the basis of the algorithms specified in EN 410:2011 or ISO 9050:2003. This is not the case for glazing that incorporates fritted glass, alone or in combination with functional thin-film coatings. The paper initially describes the different printing options for fritted glass and the fundamental principles of functional thin-film coatings. When glass surfaces are coated with glass frit, it is essential to note that the light-scattering coatings transmit and reflect incident radiation not only directly but also diffusely. The same applies when functional thin-film coatings are combined with frit coatings. Suitable measurement methods to collect the scattered radiation, measured transmittance and reflectance spectra, and the calculation of light and solar properties on the basis of the EN 410:2011 standard are presented. At the same time, the limits of this standard and the need for its extension are demonstrated. [1] Frit: a durable mixture of glass and ceramic particles, which may act as pigments.
description: Challenging Glass Conference Proceedings, Vol. 6 (2018): Challenging Glass 6
Ultraviolet Spectra of CV Accretion Disks with Non-Steady T(r) Laws
Creators: name: Orosz, Jerome A.
name: Wade, Richard A.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: An extensive grid of synthetic mid- and far-ultraviolet spectra for accretion disks in cataclysmic variables has been presented by Wade and Hubeny (1998). In those models, the disk was assumed to be in steady-state, that is T_eff(r) is specified completely by the mass M_WD and radius R_WD of the accreting white dwarf star and the mass transfer rate M_dot which is constant throughout the disk. In these models, T_eff(r) is proportional to r^{-3/4} except as modified by a cutoff term near the white dwarf. Actual disks may vary from the steady-state prescription for T_eff(r), however, e.g. owing to outburst cycles in dwarf novae M_dot not constant with radius) or irradiation (in which case T_eff in the outer disk is raised above T_steady). To show how the spectra of such disks might differ from the steady case, we present a study of the ultraviolet (UV) spectra of models in which power-law temperature profiles T_eff(r) is proportional to r^{-gamma} with gamma < 3/4 are specified. Otherwise, the construction of the models is the same as in the Wade & Hubeny grid, to allow comparison. We discuss both the UV spectral energy distributions and the appearance of the UV line spectra. We also briefly discuss the eclipse light curves of the non-standard models. Comparison of these models with UV observations of novalike variables suggests that better agreement may be possible with such modified T_eff(r) profiles.
description: 13 pages, 6 figures (one reduced quality), ApJ in press
Movable Thin Glass Elements in Façades
Creators: name: Neugebauer, Jürgen
name: Wallner-Novak, Markus
name: Lehner, Tim
name: Wrulich, Christian
name: Baumgartner, Marco
Publisher: name: Challenging Glass Conference Proceedings
Year: 2018

description: Façades play an important role in the control of energy flow and energy consumption in buildings as they represent the interface between the outdoor environment and the indoor occupied space. The option of regulating internal and external conditions acquires great relevance in new approaches to sustainable building solutions. Studies on climate adaptive façades show a very high potential for improved indoor environmental quality conditions and energy savings by moveable façades. A number of movable façades were realized in the past, but the use of thin glass with a thickness of 0.5 mm to 3 mm opens a brand-new field, that allows for playing with the geometry of the outer skin and the opportunity to make it adaptive by movement. Thin glass requires for curved surfaces in order to gain structural stiffness in static use. In kinetic façades the high flexibility of thin glass allows for new options for changes in size and position by bending of elements rather than implementing hinges in a system of foldable rigid panels. The geometry is based on the known theory of developable surfaces for keeping a low stress-level during movement. This allows for façades created from cold bent thin glass or curved laminated safety glasses produced by laminating of thin glass plies which provide better sealing, greater simplicity in construction and robustness and durability of moveable components which may be actuated autonomously. Some concepts based on the before mentioned theories were created to explain some principles and discuss their principles and applicability.
description: Challenging Glass Conference Proceedings, Vol. 6 (2018): Challenging Glass 6
Sharing Financial Risk through Flexible Farm Lease Agreements
Creators: name: Edwards, William M.
name: Hart, Chad E.
name: Edwards, William M.
name: Hart, Chad E.
Publisher: name: Unknown
Year: 2013
Subjects: subject: Farm Management
subject: Risk and Uncertainty
subject: flexible farm lease agreements
subject: flexible cash leases
subject: simulation model
subject: financial risk

description: A simulation model representing a north central U.S. corn and soybean farm was used to estimate the degree of financial risk borne by the tenant and the landlord under 10 different types of flexible cash leases. Probability distributions for yields, prices, and production costs were incorporated. Measures of risk included standard deviation of profits, probability of loss, and 10th percentile value at risk. A profit sharing lease that included rent adjustments for all three variables shifted the most risk from the tenant to the landowner, and reduced the tenant’s probability of incurring an economic loss from 51 percent to 37 percent.
Strictly In-Plane Vortex-like Excitations in Pseudogap Region of Underdoped $La_{2-x}Sr_xCuO_4$ Single Crystals
Creators: name: Wen, H. H.
name: Liu, Z. Y.
name: Xu, Z. A.
name: Weng, Z. Y.
name: Zhou, F.
name: Zhao, Z. X.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Nernst effect has been measured for an underdoped and an optimally doped $La_{2-x}Sr_xCuO_4$ single crystal with the magnetic field applied along different directions. For both samples, when $H \|$ c, a significant Nernst voltage appears above $T_c$ and keeps measurable up to a high temperature (100 K) as reported by Xu et al.[ Nature 406, 486(2000) ]. However, when $H \|$ a-b plane the Nernst signal drops below the noise level quickly above $T_c$ for the underdoped sample. Moreover, the in-plane Nernst data with field at different angles shows a nice scaling behavior with the c-axis component of the field. All these give strong indication for strictly in-plane vortex-like excitations in pseudo-gap region.
description: 5 Pages, 4 Figures, Revised Feb.4, 2003
MOESM5 of Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer’s disease related pathology
Creators: name: Joshi, Amit
name: Wassenhove, Lauren
name: Logas, Kelsey
name: Paras Minhas
name: Andreasson, Katrin
name: Weinberg, Kenneth
name: Che-Hong Chen
name: Mochly-Rosen, Daria
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 5: Figure S5. ALDH2*2/*2 deficiency increases astrocyte activation in response to ethanol-induced injury. a) C1q levels were measured using mouse Complement C1q ELISA kit in primary astrocytes in the presence or absence of Alda-1 (20 μM/24 h; 50 mM Ethanol). b) Interlukin-6 levels were determined cell supernatant of primary astrocytes using ELISA kit in the presence or absence of Alda-1 (20 μM/24 h; 50 mM Ethanol). c) TNF-α levels were determined cell supernatant of primary astrocytes using ELISA kit in the presence or absence of Alda-1 (20 μM/24 h; 50 mM Ethanol). d) Levels of cellular COX-2 at 6 h were determined by immunoblotting in primary astrocytes in the presence or absence of Alda-1 (20 μM; 50 mM Ethanol). β-actin was used as loading control. Protein levels were quantified and represented as fold change of WT Veh. e) Levels of Interlukin-1β release at 6 h were determined by immunoblotting in primary astrocytes in the presence or absence of Alda-1 (20 μM; 50 mM Ethanol). β-actin was used as loading control. Protein levels were quantified and represented as fold change of WT Veh. f) Caspase-1 activity was determined in primary astrocytes in the presence or absence of Alda-1 (20 μM; 50 mM Ethanol) using a fluorometric assay based on the cleavage of substrate YVAD-AFC. Data information: Mean, standard deviation, and p-values are shown. Results are presented as percent/ fold of control. n = 3–4 independent biological replicates; probability by one-way ANOVA (with Holm-Sidak post hoc test).
Forage Options and Drought Risk: A South Dakota Case Study
Creators: name: Fausti, Scott W.
name: Parvez, Md Rezwanul
name: Nleya, Thandi
name: Johnson, Patricia
name: Olsen, Kenneth
name: Rickertsen, John
name: Fausti, Scott W.
name: Parvez, Md Rezwanul
name: Nleya, Thandi
name: Johnson, Patricia
name: Olsen, Kenneth
name: Rickertsen, John
Publisher: name: Unknown
Year: 2013
Subjects: subject: Farm Management
subject: forage crop production
subject: increased drought risk
subject: livestock production

description: In the Northern Great Plains region, crop and livestock producers view forage crop production as an important component of their farm management system. During periods of increased drought risk, alternative annual forage crops may provide producers with a risk reducing alternative to traditional forage crops. An alternative forage crop production study (20 varieties) was conducted by South Dakota State University over a three year period (2008-2010). Three management decision criteria options were used to evaluate the economic value and economic risk associated with the production of spring and summer annual forage crops (Expected Value, Max-Min, and Minimum Coefficient of Variation). Empirical findings suggest that producer risk management goals and how the alternative forage crop will be used (grazing versus cash crop) should play a role in crop variety selection. We recommend planting both spring and summer varieties to provide diversification during periods of increased drought risk.
Australeon manselli
Creators: name: Miller, Robert B.
name: Stange, Lionel A.
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Neuroptera
Myrmeleontidae
Australeon
Australeon manselli

description: Australeon manselli (New and Matsura), new combination
 Callistoleon manselli New and Matsura 1993: 93, figures 1-9 (wings, male, female terminalia, male genitalia, spermatheca). Holotype female, Carnarvon, Queensland, Australia (reared) (ANIC).
 Biology: Mansell 1988: 351-356, figures 1-6 (pitfall traps as C. illustris); Matsura and Kitching 1993: 77- 84.
 Description. Adult: body length 26 to 29 mm, forewing length 26 to 33 mm, hindwing length 26 to 32 mm. Coloration: vertex black, slightly paler along central length of epicranial sutures; posterior onehalf of frons black, anterior one-half of frons and remainder of face tawny orange, central region pale gray; abdomen dark gray to black; wings with pale venation except subcosta dark brown at origins of costal crossveins and where enclosed in dark brown spots; spots variable, not reaching margins, generally distributed along radial area, cubital area and posterior area at middle; with small dark spots at rhegma and pterostigma; hindwing with dark brown spots mainly at pterostigma and rhegma; wings weakly fumose posteriorly. Chaetotaxy: female ectoproct with 3-4 thickened setae; lateral gonapophysis with about 8 long, moderately thickened setae; anterior gonapophysis with about 8 long moderately thickened setae that are as long as gonapophysis. Structure: pronotum broader than long; legs moderately sturdy, tibial spurs reach beyond tarsomere II; wings moderately broad; female with ectoproct ventrally lobed; lateral gonapophysis not conspicuously broad; posterior gonapophysis long, slender; anterior gonapophysis about as broad as lateral gonapophysis; male with broad ectoproct, sternite IX tapered; genitalia with broad gonarcus, apex transverse, mediuncus shallow; parameres with strong anterior flange, heavily sclerotized along inner and ventral sides.
 Distribution. Queensland.
 Discussion. The anterior region of the frons is pale yellow in A. manselli in contrast to the dark brown anterior frons of A. illustris. Also, the wings appear to be broader in A. manselli than in A. illustris. Australeon manselli has been found only at Carnarvon in Queensland.
description: Published as part of Miller, Robert B. & Stange, Lionel A., 2012, The cave mouth antlions of Australia (Neuroptera: Myrmeleontidae), pp. 1-65 in Insecta Mundi 2012 (250) on pages 41-42, DOI: 10.5281/zenodo.5174820
2MASS Studies of Differential Reddening Across Three Massive Globular Clusters
Creators: name: Law, David R.
name: Majewski, Steven R.
name: Skrutskie, Michael F.
name: Carpenter, John M.
name: Ayub, Hina F.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: J, H, and K_S band data from the Two Micron All-Sky Survey (2MASS) are used to study the effects of differential reddening across the three massive Galactic globular clusters Omega Centauri, NGC 6388, and NGC 6441. Evidence is found that variable extinction may produce false detections of tidal tails around Omega Centauri. We also investigate what appears to be relatively strong differential reddening towards NGC 6388 and NGC 6441, and find that differential extinction may be exaggerating the need for a metallicity spread to explain the width of the red giant branches for these two clusters. Finally, we consider the implications of these results for the connection between unusual, multipopulation globular clusters and the cores of dwarf spheroidal galaxies (dSph).
description: 40 pages, 14 figures. Accepted for publication in Oct. 2003 AJ
Economics of Precision Agricultural Technologies Across the Great Plains
Creators: name: Smith, Craig M.
name: Dhuyvetter, Kevin C.
name: Kastens, Terry L.
name: Kastens, Dietrich
name: Smith, Logan
name: Smith, Craig M.
name: Dhuyvetter, Kevin C.
name: Kastens, Terry L.
name: Kastens, Dietrich
name: Smith, Logan
Publisher: name: Unknown
Year: 2013
Subjects: subject: Crop Production/Industries
subject: precision agricultural technology

description: Precision agricultural technologies, such as guidance systems and automatic section controllers, have given farmers the ability to more effectively apply crop inputs such as fertilizer, pesticides, and seed. More efficient use of inputs often can be translated into higher yields and/or lower costs, but the costs and benefits likely vary across regions. Our research incorporates over 500 real-world cropland fields from farms in Colorado, Kansas, and Nebraska to help answer the research question: What are the economics of investing in guidance systems and automatic section controllers for sprayers, and how do these vary across different regions of the Great Plains?
title: Examining Simple Joint Macroeconomic and Term-Structure Models: A Practitioner's Perspective
Creators: name: David, Jamieson
name: Liu, Shudan
Publisher: name: Bank of Canada
Year: 2007

description: The primary objective of this paper is to compare a variety of joint models of the term structure of interest rates and the macroeconomy. To this end, we consider six alternative approaches. Three of these models follow from the work of Diebold and Li (2003) with a generalization in Bolder (2006). The fourth model is a regression-based approach motivated entirely by empirical considerations. The fifth model follows from the seminal work of Ang and Piazzesi (2003), who suggest a joint macro-finance model in a discrete-time affine setting. The final model, which we term an observed-affine model, represents an adjustment to the Ang-Piazzesi model that essentially relaxes restrictions on the state-variable dynamics by making them observable. The observed-affine model is similar in spirit to work by Colin-Dufresne, Goldstein, and Jones (2005) and Cochrane and Piazzesi (2006). Using monthly Canadian data from 1973 to 2005, we compare each of these models in terms of their out-of-sample ability to forecast the transition density of zero-coupon rates. We also examine a simple approach aimed at permitting a subset of the parameters in the non-affine models to vary over time. We find, similar to Bolder (2006), that the Diebold and Li (2003) motivated approaches provide the most appealing modelling alternative across our different comparison criteria.
description: Le but premier des auteurs est de comparer entre eux différents modèles qui formalisent à la fois la dynamique de la structure des taux d'intérêt et celle de l'économie. Des six modèles qu'ils considèrent, trois s'inspirent des recherches de Diebold et Li (2003) et d'une généralisation du modèle de ces derniers présentée par Bolder (2006). Le quatrième modèle fait appel à l'analyse de régression et est motivé exclusivement par des considérations empiriques. Le cinquième modèle s'inscrit dans la lignée des travaux novateurs d'Ang et Piazzesi (2003), qui suggèrent l'emploi d'un modèle macrofinancier de type affine formulé en temps discret. Le dernier, le modèle affine à facteurs observables, est une variante du modèle d'Ang et Piazzesi où l'on a recours à des variables d'état observables au lieu d'imposer des restrictions à la dynamique de ces variables. Le modèle affine à facteurs observables emprunte à la démarche de Colin-Dufresne, Goldstein et Jones (2005) et de Cochrane et Piazzesi (2006). À l'aide de données canadiennes mensuelles allant de 1973 à 2005, les auteurs comparent la capacité de chacun de ces modèles à prévoir la densité de transition des taux d'obligations coupon zéro au-delà de la période d'estimation. Ils analysent également une méthode simple devant permettre à un sous-ensemble des paramètres des modèles non affines de varier dans le temps. À l'instar de Bolder (2006), ils constatent que les modèles prenant appui sur les travaux de Diebold et Li (2003) sont les plus prometteurs eu égard aux critères de comparaison retenus.