cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Pilot to Transition HIV +/- Opiate Users to Community
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Lay Abstract Pilot to Transition HIV +/- Opiate Users to Community California laws have restricted opioid replacement therapy options in many communities and this has made it virtually impossible for jails to begin opioid replacement therapy on incarcerated opioid addicts. Physicians can now prescribe effective opioid replacement therapy for opioid dependent persons using Buprenorphine, including persons who are incarcerated. In San Francisco, leadership in public health and in the sheriff's department has been supportive of providing opioid replacement therapy to HIV+ and HIV- addicts, but the program in the jail has been slow to be implemented. The State of California has a large number of persons at risk for HIV through injection drug use, a great need for prevention interventions for HIV+ opioid drug users, and one of the highest rates of incarceration of its population of any state in the US. We propose a pilot study of opiate replacement therapy with Buprenorphine in the San Francisco jails with implementation of an intervention to link incarcerated persons to community maintenance Buprenorphine and healthcare after release. This pilot study would make resources and personnel available to energize the Buprenorphine program and systematically evaluate the participants. In doing so, this study will provide a statewide and potentially national model for HIV prevention interventions in a totally underserved setting: jails and prisons. Our specific aims are to: Specific Aim 1: Describe the effect of opioid replacement therapy with Buprenorphine on the sexual and drug use risk behaviors of a group of HIV+ and HIV- opioid addicts started on treatment in the San Francisco jails, Specific Aim 2: Identify the characteristics of HIV+ and HIV- opioid addicted adults who continue on Buprenorphine after release from jail and, Specific Aim 3: Test the effects of a transition program for jail inmates on maintenance on Buprenorphine after release into the community.
Drosophila incompta Wheeler & Takada in Wheeler et al. 1962
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila incompta

description: incompta Wheeler & Takada in Wheeler et al., 1962: 408. Type locality: Panama, Bocas del Toro, Almirante. HT M (USNM). NT Distr.: West Indies, Mexico to Argentina.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 727, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Resolving Hiatus
Creators: name: Casali, Roderic F.
Publisher: name: No Publisher Supplied
Year: 1996

description: An examination of 92 languages which resolve hiatus through Vowel Elision and/or Coalescence (merger) reveals two correlations that pose interesting challenges for phonological theory.  First, in certain contexts the vowel targeted by Elision is universally predictable.  At (non-function) word boundaries for example, languages consistently elide the leftmost (word-final) vowel.  Second, the type of Coalescence possible in a language depends on the language's vowel inventory.  While seven-vowel systems coalesce /a+i/ to [E], for example, nine-vowel systems coalesce this sequence to [e]. These generalizations are analyzed within the framework of Optimality Theory. My analysis of Elision assumes that languages make greater effort to preserve features occurring in certain phonetically or semantically prominent positions (e.g. in roots). Corresponding to these are a series of position-sensitive Faithfulness constraints requiring preservation of features in these positions.  The possible rankings of these constraints yield an Elision typology in good agreement with attested patterns. The Coalescence correlations strongly suggest that the height features of a vowel depend on the inventory in which the vowel occurs, a claim supported by other facts as well. I propose that (auditorily defined) height features are assigned to vowel systems via best satisfaction of a set of constraints on height specification, for example a constraint requiring minimal use of certain features. The specifications assigned to a given vowel system will, in conjunction with a uniform ranking of Faithfulness constraints that characterizes Height Coalescence across all the systems, correctly generate the possible patterns in that type of system. In its prototypical form, Elision is position-sensitive: the elided segment is the one that occupies a particular position. (Symmetric) Coalescence, on the other hand, is feature-sensitive: the resulting vowel retains the most highly-preferred features from the original vowels. Also attested are a "Feature-Sensitive" Elision process in which the vowel preserved is the one which possesses particular feature(s), and a type of  "Asymmetric" Coalescence, in which positional and featural preferences both play a role. All four processes are correctly generated by the analysis, arising under different permutations of the same constraints posited to account for Elision and Coalescence in their prototypical incarnations.
Plasmacytoid dendritic cells in HIV-1 infection
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The immune system is composed of specialized cells that protect the body from infectious agents, such as bacteria and viruses. This host response to disease-carrying microbes can be subdivided into two major branches: adaptive and innate immunity. The adaptive immune response is composed of B cells and T cells, and includes CD4+ T cells which are the target of HIV. As the name would suggest, adaptive immune cells are generated days to weeks after an infection occurs and target specific components of an infectious agent. In innate immunity, cells respond within minutes to days after infection and have broad specificity against invading organisms. This rapid response makes innate immune cells the body’s first line of defense against foreign microbes. Our research studies focus on the plasmacytoid dendritic cell (PDC), an important part of the innate immune response. In response to infections, such as HIV, PDCs produce a potent antiviral protein called interferon (IFN)-?. Studies in the laboratory have shown that IFN-? can prevent virus production in HIV-infected cells. Clinical research has found that increased numbers of PDC circulating in the blood of HIV-infected individuals is associated with a healthy clinical state. These findings suggest that PDC production of IFN-? could curtail HIV pathogenesis. An objective of this proposed study is to examine whether there are changes in the ability of PDCs to produce IFN-? in HIV+ individuals at different clinical states. Another objective is to determine how PDCs detect HIV infection. Finally, we wish to visualize through microscopy the processes involved in the recognition of HIV by the PDC. This knowledge could lead to novel therapies that use PDC to control HIV infection.
Prosodic phonology in Bamana (Bambara): Syllable complexity, metrical structure, and tone
Creators: name: Green, Christopher Ryan
Publisher: name: No Publisher Supplied
Year: 2010

description: This dissertation characterizes three components of prosodic phonology, namely syllable structure, metrical structure, and tone, in Bamana (Bambara), a Mande language of West Africa, and its related varieties. Of primary interest is the Colloquial (non-standard) variety of Bamana spoken in Bamako, Mali, by a young cohort of individuals. It is shown that Colloquial Bamana differs in significant ways from other phonologically conservative or normative varieties of the language, most noticeably in its inventory of permitted complex syllable shapes. This thesis illustrates that the synchronic emergence of complex syllables in this language variety is bounded and restricted by higher prosodic structure in the language. It is demonstrated that prosodic domains in the form of disyllabic metrical feet are present in the language and play a role in driving the outcome of two complementary and at times competing processes of segmental reduction that are active in generating the noted complex syllable types. The overall goal of this thesis is to describe and analyze the mechanisms underlying these processes and prohibitions and to explore the implications that their presence has for both descriptive and theoretical phonology, as well as for phonological change in this and other related Mande languages. Alongside these explorations into syllable complexity and metrical structure, this dissertation sheds new light on the tonal phonology of Bamana, a subject that has been shrouded in controversy for many years. By considering the tonal results or consequences of segmental minimization in Colloquial Bamana, the thesis offers new ideas on structures, processes, and changes underway in the language’s tonology. Topics explored in detail include tonal feet, tonal compactness, and tonal word melodies.
Pristidae Bonaparte 1838
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Pristiformes
Pristidae

description: Family Pristidae Bonaparte, 1838
Sawfishes
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 44, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Rhinobatos schegelii
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Rajiformes
Rhinobatidae
Rhinobatos
Rhinobatos schegelii

description: Rhinobatos cf. schegelii
Enigma Guitarfish
Local synonymy: White et al., 2018: 208, figs (PNG).
PNG voucher material: (1 spec.) NMV A 14200, female 700 mm TL, no locality data [presumably southeastern PNG], 1890.
Remarks: Only known from a single specimen labelled as collected by Andrew Goldie in 1890. Andrew Goldie collected in southeastern PNG only, from the Gulf of Papua to Milne Bay Province. Very similar to Rhinobatos schegelii from Taiwan and Japan and possibly conspecific. Some doubts exist over the locality of this specimen as PNG given that in the tropical Indo-West Pacific region, members of this genus typically occur in deeper shelf or upper slope waters, at a depth unlikely to have been fished in PNG in the 1890s. Additional specimens are required to confirm the validity of this species in PNG waters.
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 49, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Drosophila leukorrhyna Pipkin 1964
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila leukorrhyna

description: leukorrhyna Pipkin, 1964: 224. Type locality: Panama, Canal Zone, Madden Forest. LT M (USNM). NT Distr.: Colombia (Valle del Cauca (Buenaventura)), Panama. Refs.: Pipkin et al., 1966: 142.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 727, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Effect of Valganciclovir on Endothelial Function in HIV Pts
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cardiovascular disease is the number one cause of death in the United States. For patients with HIV infection, the use of antiretroviral therapy has decreased HIV-related morbidity and mortality; however, as the HIV population continues to age, cardiovascular disease is becoming an important new health issue for HIV-infected patients that will likely continue to increase in incidence in the future. Recent studies suggest that patients with HIV are at increased risk for cardiovascular events. The mechanism behind this process remains unclear. In patients without HIV, inflammation and the immune system have been shown to be important in the development of coronary artery disease. Preliminary work from our group has shown that immune responses in the setting of Cytomegalovirus (CMV) infection are associated with coronary artery disease in HIV patients. For this proposal, I plan to add two additional measurements to an already approved and funded study, which is a randomized placebo-controlled trial of valganciclovir (an anti-CMV medication). By adding two additional measures to this study, we will be able to determine if valganciclovir therapy is associated with changes in two different tests are predictive of cardiovascular outcomes. The first test is a test of endothelial function. This test is noninvasive and uses ultrasound to measure the diameter of one of the arteries in the arm before and after nitroglycerin treatment. The second test is a blood test in which levels of circulating endothelial cells will be measured using antibodies and laboratory equipment to count cells. This study will enable us determine whether treatment with valgancyclovir results in improved endothelial function (Aim 1), and whether treatment with valganciclovir will result in higher levels of circulating endothelial progenitor cells (Aim 2). We predict that treatment with valganciclovir will result in improved endothelial function as measured using ultrasound and higher levels of endothelial progenitor cells. These findings would prompt us to design future studies to see if patients with HIV who are at high risk for cardiovascular events should be treated with anti-CMV medication.
First Reformed Church, New Brunswich, N.J.: Rev. Thomas C. Easton, D.D., Pastor, 1885
Creators: name: First Reformed Church (New Brunswick, N.J.)
Publisher: name: Fredonian Print
Year: 1885

description: The 1885 yearbook for the First Reformed Church of New Brunswick, N.J. Includes pastors report; summary of membership; births and deaths; finances; information on Sabbath School; and suggestions from the pastor.
Anoxypristis White & Moy-Thomas 1941
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Pristiformes
Pristidae
Anoxypristis

description: Genus Anoxypristis White & Moy-Thomas, 1941
Knifetooth Sawfish
Anoxypristis White & Moy-Thomas, 1941: 397. Type by being a replacement name for Oxypristis Hoffmann, 1912, preoccupied by Oxypristis Signoret, 1861 in Hemiptera.
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 44, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
A New Mouse Model of PI3'-Kinase Induced Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: PI 3-kinases have been linked to a diverse group of cellular functions, including cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. PI 3-kinases are heterodimeric (two different protein subunits) molecules composed of a regulatory and a catalytic subunit. Mutations of the PI 3-kinase gene, termed PIK3CA, which encodes the p110? catalytic subunit, are frequently detected in various human cancers. In breast cancer, PIK3CA is mutated in 8-40% patients. To date, PIK3CA mutations have been shown to not only exert direct oncogenic effects through enhanced activity of PI 3-kinase, but also play a role in drug resistance and overall prognosis. Due to the association between p110? and cancer, it is believed to be a promising drug target.

 Despite the availability of various cell-based systems to dissect oncogenic transformation and human tissue samples for descriptive analysis of PIK3CA mutations, there is no mouse model system to explore its role in breast cancer initiation and progression. Such a model, if well designed, will facilitate not only the understanding of the mechanisms of the activating mutations for PIK3CA as an oncogene in breast cancer, but also provide a chance to study the interaction of this oncogene with tumor suppressors (e.g. p53 and INK4A/ARF) by crossing the mice accordingly to produce desired genetic background.

 Our aims are to: (1) generate genetically manipulated mice with PIK3CA mutation(s) capable of being conditionally activated in mammary epithelial cells and cause tumorigenesis; (2) investigate the effect of loss of tumor suppressor p53 in the context of activation of PIK3CA mutation(s); and (3) test the therapeutic effects of inhibitors of PI 3-kinase and compare them with conventional chemotherapy. Standard subcloning and/or genetic recombination techniques will be exploited for the construction of a targeting PIK3CA mutation(s). The mice will be generated by introducing the mutant genes into mouse embryonic stem (ES) cells. Mammary tumorigenesis will be achieved by crossing our mice with MMTV-Cre or WAP-Cre mice to allow mammary-specific expression. We will also cross the mice with mice harboring tumor suppressor p53 that can be conditionally inactivated. Inhibitors of PI 3-kinase and its downstream effectors and/or chemotherapeutic agents will be administered appropriately after mammary tumors are formed.

 We anticipate that this study will demonstrate the oncogenic effect of activating PIK3CA mutation(s) in breast cancer in a causal-effect manner. By investigating the relationship with certain tumor suppressors (e.g., p53) and comparing the effect of PI 3-kinase inhibitors with conventional chemotherapy, we will evaluate the possibility of targeting PIK3CA as an independent therapy for breast cancer.
Anoxypristis cuspidata
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Pristiformes
Pristidae
Anoxypristis
Anoxypristis cuspidata

description: Anoxypristis cuspidata (Latham, 1794)
Knifetooth Sawfish
Pristis cuspidatus Latham, 1794: 279, pl. 26 (fig 3). Neotype: MNHN 0000-1250. Type locality: Malabar, India.
Local synonymy: Platypristis cuspidata— Filewood, 1973: 10 (PNG). Platypristis cuspidatus— Filewood, 1973: 10 (PNG). Anoxypristis cuspidata — Kailola, 1987: 24 (Daru; Gulf of Papua; Hall Sound; Yule Island; Bootless Bay; Orangerie Bay; Darapap; south of Ramu River mouth); White et al., 2017a: 277 (PNG); White et al., 2018: 192, figs (PNG). Anoxypristis cuspidatus — Taniuchi & Shimizu, 1991: 5 (Oriomo River Estuary).
PNG voucher material: (3 spec.) FUMT ̄P10855, male 1182 mm TL, Oriomo River Estuary, Western Province, 24 Sep. 1989; KFRS E.619, female 1330 mm TL, west of Avirara, Gulf of Papua, 8°18’39” S, 146°11’27” E, 12–14 m depth, 27 Aug. 2015; KFRS E.796, female embryo 570 mm TL, Nigoherm Islands, Bismarck Archipelago, 0°33’ S, 144°10’ E.
Remarks: First recorded from PNG by Filewood (1973). White et al. (2017a) summarises sawfish records from PNG but most survey reports only record ‘sawfish’ with species verification not possible. Dried fins observed from coastal fisheries during recent surveys in the Gulf and Western Provinces; whole specimens observed in prawn trawl bycatch during recent surveys; commonly caught at the mouth of the Sepik River and off Broken Water Bay in East Sepik Province. An additional 16 specimens (9 registered lots) from the KFRS collection are considered lost or destroyed.
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 45, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Drosophila limbinervis Duda 1925
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila limbinervis

description: limbinervis Duda, 1925: 215. Type locality: Costa Rica, Catargo, La Suiza de Turrialba. LT M (HNHM). NT Distr.: El Salvador to Colombia (Magdalena (Sierra Nevada de Santa Marta)). Refs.: Hoenigsberg, 1995b: 177.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 727, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Prediction of breast tumor response to novel TGFB inhibitors
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Transforming growth factor-beta (TGF?) is a secreted protein that is generated in abundance from tumors cells; and, there is a strong correlation between high levels of tumor-derived TGF? and poor prognosis. In cell culture and animal models, TGF? has been shown to promote processes that stimulate metastasis. Moreover, animal models have shown that inhibition of TGF? signaling can be effective and safe in reducing breast tumor metastasis. As a result of these successes in animals, various anti-TGF? therapeutics are currently entering clinical trials for oncology applications. Despite the potent anti-metastatic action of TGF? inhibitors for certain tumors, it has been known for a decade that TGF? can have tumor promoting actions depending on the tumor

 context. Thus, the inherent complexity of TGF? action in cancers calls for a tailored application based on the biological profile of the individual tumor, which may be defined by molecular analysis. In general, relatively benign tumors are growth inhibited by TGF?, whilst more aggressive tumors are stimulated to invade and metastasize. The dichotomous actions of TGF? necessitate the selection of those tumor subtypes that will have positive therapeutic response.

 The purpose of this project is to design a molecular screen for clinicians that will predict the breast tumor’s response to novel small molecule inhibitors of TGF? signaling (positive or negative), ultimately facilitating patient selection for treatment. A second aim will be to determine at the molecular level how the drugs work, which will lead to identification of new therapeutic targets. To this end, our first aim is to profile the gene expression patterns of breast tumors to study gene signatures associated with TGF? clinical outcome. We will use a panel of fifty-one breast carcinoma cell lines that have been extensively characterized with respect to gene profiles, and these cell lines will be treated with two distinct and novel TGF? inhibitors. They will be measured for responses in terms of proliferation, cell viability, apoptosis, invasion, and migration. Then, biocomputational analysis will be used to define the predictive genetic signatures of the various tumor response subtypes. Finally, the gene expression responses of the breast carcinoma subtypes will be analyzed further in an effort to identify the actual targets of the biological response to TGF? inhibitors.

 The information generated from this study will help predict which patients are most likely to benefit from anti-TGF? therapy, and spare patients who will not respond well to treatment. Ultimately these could lead to breakthrough clinical trials, so that these promising and relatively non-toxic inhibitors can be used effectively.
God's presence through the year : a discourse delivered in the First Reformed Church, New-Brunswick, December 31, 1876 / by Richard H. Steele.
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1876

description: The year reviewed in New Brunswick's oldest church - The political crisis - Gravity of the situation - The financial condition - Courage of the people - Our church the pioneer - Her ministry - The three building for worship - The last thirteen years - Facts and figures - The centenial year - Revival - The outlook
Bartonella virulence mechanisms in patients with AIDS
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Bartonella henselae (BH) and B. quintana (BQ) are arthropod-borne, emerging, bacteria that cause bacillary angiomatosis (BA). BA lesions are unique, potentially fatal, tumors of blood vessels affecting HIV-infected patients. Recurrent and prolonged infection in the blood is another manifestation of Bartonella infection that occurs in patients at all stages of HIV infection. Bartonella infections represent a threat to the health of AIDS patients in California, where the majority of the US cases of HIV-associated Bartonella infection have been diagnosed; BQ disproportionately affects the HIV-infected homeless population in California. Because Bartonella infection was only identified in the US in the past 15 years, almost nothing is known about how Bartonella causes infection in humans. The goal of our research is to identify how the BQ bacteria are able to infect the skin and blood of patients with HIV-infection and cause serious illness. Almost all bacteria need to take up iron in order to survive. We are currently focusing our research on how BQ obtains iron from its environment, and in what form the iron needs to be for BQ to successfully use it. BQ preferentially uses iron in the forms known as heme and hemin. Heme is the component of hemoglobin that carries oxygen; hemin is the ferric chloride form of heme. Both hemin and heme are utilized by BQ as a source of iron. The Specific Aims of this pilot project are: 1) identification and characterization of genes involved in the transport of hemin into and out of BQ; and 2) identification of how temperature affects the uptake of heme and hemin in BQ. We identified several unusual mutant BQ when we were searching for BQ that were unable to process iron in the normal way. We will further characterize these mutants functionally in the test tube, by cutting out each of the three genes we identified, one at a time, and then determining what happens to the BQ bacterium without the gene. We will also continue to look for additional BQ mutants that are defective in using hemin and heme. Studying these mutants closely will likely reveal how BQ is able to survive toxic levels of hemin while residing in the intestinal tract of the body louse vector, as well as while circulating within erythrocytes in the bloodstream of the human host. BQ occupies these two very unusual niches, the human body louse and in the human blood cells. Information about how BQ is able to do this will likely provide insight into how cells work in humans, as well as how molecules function inside of the body louse. Ultimately, this new information will lead to potential strategies for improved treatment of HIV-infected patient (e.g., preventing recurrent infection in the bloodstream) and prevention of infection in the first place (e.g., eradicating BQ from the body louse intestines before it is passed to the human).
CNAR inhibits HIV replication by impairing transcriptional i
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The number of HIV infected individuals has been increasing around the world. This basic science project will be beneficiary to the countries hit by HIV epidemics, because of the improved understanding of the innate immune system of anti-viral resistance mediated by CNAR and CAF . This new knowledge will increase our possibility to eradicate the virus and potentially can bring new anti-HIV therapies that could use natural immunological responses without depending only on the drugs targeting the HIV.
First Reformed Church: Neilson Street, Head of Hiram, New Brunswick, NJ
Creators: name: First Reformed Church (New Brunswick, N.J.)
Publisher: name: No Publisher Supplied
Year: 1889

description: The 1889 guide to the First Reformed Church of New Brunswick, NJ. Contents include a list of former pastors, Consistory, schedule of services, a report on the state of the Church, list of current members, and information on the sabbath school, the Choir, Ladies Missionary Society, and the Young Ladies Missionary Band.
Amtliche Mitteilungen der Technischen Universität Dortmund Nr. 1/2025
Creators: name: (:Unkn) Unknown
Publisher: name: Technische Universität Dortmund
Year: 2025
Subjects: subject: 080

description: Verwaltungs- und Benutzungsordnung des Instituts für Philosophie und Politikwissenschaft der Fakultät Humanwissenschaften und Theologie der Technischen Universität Dortmund vom 7. Januar 2025
description: Amtliche Mitteilungen der Technischen Universität Dortmund ; 2025
Drosophila lindae Wheeler 1968
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila lindae

description: lindae Wheeler, 1968: 431. Type locality: Colombia, Cauca, S Piendamó, about 30 km N Popayán. HT M (USNM). NT Distr.: Bolivia, Colombia, Peru.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 727, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
title: Assessing Sedentary Behavior and Physical Activity with Wearable Sensors
Creators: name: Freedson, Patty
Publisher: name: eScholarship@UMMS
Year: 2014

description: As part of the mini-symposium entitled "Physical Activity, Sedentary Behavior and Function in Individuals with Knee and Hip Osteoarthritis: Clinical Observations and Opportunities for Future Research," Dr. Freedson highlights her group's research on using wearable monitors to objectively quantify changes in physical activity and sedentary behavior in individuals with moderate to severe knee and/or hip osteoarthritis.
A MOLECULAR STRATEGY TO INHIBIT BREAST CANCER METASTASIS
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: A novel cellular pathway recently discovered in the principal investigator’s laboratory is likely to contribute to breast cancer metastasis. Research in the laboratory has focused for many years on a protein, called clathrin, and its role in membrane traffic. Clathrin facilitates the formation of small vesicles within cells. Clathrin-coated vesicles selectively sort materials to be transported within cells at the cell membrane, the internal Golgi network, and other internal cell compartments for “traffic control.” In the context of breast cancer, clathrin controls hormone uptake into the cell. Recent work in the laboratory has revealed that clathrin through its interaction with a second protein called Hip1 (Huntingtin Interacting Protein-1), also controls how cells move and can spread through the body. It is already known that the Hip1 protein is present in excess in certain types of breast cancer, and correlates with poor survival in patients with prostate cancer. We believe that excess Hip1 in breast cancer cells might be linked to increased spreading behavior. Our studies of clathrin and Hip1 also allow us to search for potential drugs that might block their interaction providing the basis for designing new breast cancer therapeutics.

 First, our studies will quantify Hip1 expression at both the mRNA and protein levels in a panel of 51 breast cancer cell lines established by the Breast Cancer Special Program for Research Excellence (SPORE) under the auspices of Dr. Joe W. Gray (Lawrence Berkeley Labs and UCSF). Hip expression will be evaluated and correlated with other characterized properties of the cell lines (already published), including migratory behavior. Cell lines with reduced Hip expression will be tested for increased migratory behavior upon induced over-expression of Hip proteins. To validate whether elevated levels of Hip expression correlate with increased metastatic potential, experimental metastasis assays in mice will be performed with Dr. Andrei Goga (UCSF), using breast cancer cell lines engineered to express different levels of Hip proteins. In addition, the ability of these cell lines to form tumors in vivo will be assessed after subcutaneous injection. Other work in our lab will employ recombinant protein expression and peptide binding assays to develop an automated, high-throughput screen to identify small molecule inhibitors of Hip-clathrin interactions. Identification of effective small molecule inhibitors provides a starting point for further drug discovery.

 This research project will investigate a novel pathway that has not yet been clearly established as playing a role in breast cancer, although research elsewhere has shown strong indications that clathrin and Hip proteins may play a substantial role in tumor biology processes related to cell movement.
Drosophila margarita Hunter 1979
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila margarita

description: margarita Hunter, 1979: 379. Type locality: Colombia, near Bogotá. HT M (CAS). NT Distr.: Colombia (Bogota, D:C). Refs.: Vilela & Bächli, 1990: 88; Hunter, 1992: 198.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 728, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Glaucostegidae Last, Seret & Naylor 2016
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Elasmobranchii
Rhinopristiformes
Glaucostegidae

description: Family Glaucostegidae Last, Séret & Naylor 2016c
Giant Guitarfishes
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 49, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Inactivation of HIV-1 by Metalloporphyrin compounds
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: In the past decade, antiretroviral HIV-1 medication has transformed the course of the HIV-1 epidemic in both developed and developing countries alike. However, as more HIV-1 infected patients receive the medication in the population, the problems of high resistance escape mutation rates as well as the complications of personal long-term antiretroviral use warrant a greater effort to identify alternative drug candidates to prevent the transmission of HIV-1. This research proposal outlines the ways in which metalloporphyrins, a novel class of drug compounds, can be a potential drug candidate to inhibit the infection, replication and propagation of HIV-1 virus. Heme is one type of metalloporphyrin that is metabolized naturally in host mammalian organisms, and is the chemical for a myriad of proteins. It is an important house-keeping molecule that is tightly regulated in the course of red blood cell turnover. In the past, researchers have studied the effects of how metalloporphyrin compounds such as heme can inhibit HIV-1 replication in tissue cultures when administered in high concentrations. However, the exact method of how these metalloporphyrin compounds can inactivate HIV-1 is not clear. In order to utilize metalloporphyrins as a novel therapeutic, it is essential that the exact ways in which various HIV-1 genes are inhibited are known. This research proposal hopes to address this mechanism by studying the interaction of metalloporphyrins with three candidate HIV-1 genes that are responsible for the fusion, propagation, and the replication of the virus. Due to issues such as escape mutations and long-term side effects of existing anti-retroviral medications, it becomes important and necessary to explore alternative drug candidates- particularly ones with a favorable bioavailability and metabolic profiles such as metalloporphyrins. The studies outlined in this proposal will elucidate whether metalloporphyrin compounds could represent a new class of antiretroviral drugs in the treatment of chronic HIV-1 infection.
D2.1 First report on the H2IOSC Landscapes
Creators: name: MONACHINI, MONICA
name: Quochi, Valeria
name: Luzietti, Roberta Bianca
name: MOSCATI, PAOLA
name: CARAVALE, ALESSANDRA
name: CHIRIVÌ, ALESSANDRA
name: Degl'Innocenti, Emiliano
name: Spadi, Alessia
name: CARADONNA, MARTA
Publisher: name: Zenodo
Year: 2025

description: The Humanities and Heritage Italian Open Science Cloud (H2IOSC) project involves four Italian nodes of research infrastructures (RIs) - CLARIN, DARIAH, E-RIHS, and OPERAS. Within this project, the second work package focuses on establishing, mapping, and monitoring strategies for assessing the national and international operation contexts for the four RIs, the characteristics of their user communities, and the specific data resources, services, and tools that are most needed, used and newly created.

The main objective of this work package is to conduct a comprehensive survey of the landscape of language technologies, humanities, and heritage science in Italy. This survey takes into account existing projects, resources, tools, communities, best practices, and standards that need to be integrated into the national Marketplace as well as the repositories of the four RIs. Collaboration within the work package was directed at structuring shared procedures for developing, managing, and adapting the survey's main objectives. Priority was on identifying and engaging key stakeholders within various communities. The surveying activity was organized around a set of shared activities, in parallel with others conducted by each infrastructure. The initial coordination activity focused on defining dimensions and criteria to guide the survey. It resulted in the creation of a structured questionnaire, which was designed to gather information about user needs, engage with stakeholders, identify communities of reference, evaluate relevant projects, and assess the FAIRness of data. The questionnaire was employed to gather insights on a wide range of topics, including data resources, software, tools, projects, training needs, prior knowledge of RIs, publications, and feedback. Such a questionnaire has been distributed among the relevant disciplinary communities and sub-communities of the four RIs. Respondents included students, researchers, professors, and subject matter experts in social science, digital humanities, and cultural heritage research fields. Preliminary results from the control group gave insights into the challenges and opportunities of the survey. Respondents have shared valuable information about data resources, technologies, software, and their training needs. The results highlight the need for clearer communication, dissemination activities, and better engagement strategies to encourage participation from the wider community. Addressing the lack of awareness regarding FAIR principles and fostering collaboration with researchers will be crucial moving forward. Future activities will involve data analysis, conducting interviews based on survey responses, and exploring strategies for integrating technology and software resources into the H2IOSC marketplace.
Bamboo: An Ecological, Economic, and Cultural Keystone for Sustainable Development
Creators: name: B. Roghan1, B. Sivakumar2
Publisher: name: The Science world a Monthly e magazine
Year: 2025

description: Bamboo, a group of perennial evergreens in the grass family Poaceae, holds immense ecological, economic, and cultural significance. Renowned for its rapid growth due to a unique rhizome-dependent system, bamboo is widely distributed across South Asia, Southeast Asia, and East Asia. Its hollow stems, scattered vascular bundles, and lack of secondary growth wood contribute to its unique structural properties. This document explores bamboo's geographical distribution, soil and climatic requirements, propagation techniques, silvicultural practices, and its economic and medicinal value. Sustainable management practices, including appropriate harvesting cycles and propagation methods, are crucial for maximizing bamboo productivity and ensuring long-term ecological balance. Despite challenges such as flowering-induced mortality and susceptibility to biotic interferences, bamboo's versatility as a construction material, food source, and medicinal agent highlights its indispensable role in various industries and cultures.Bambusa bamboo
title: Didaktische Potenziale des "Arte Journal Junior" für den Anfangsunterricht Französisch
Creators: name: Unger, Marcus
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: Fremdsprachendidaktik
subject: Authentizität
subject: Franzözisch
subject: Materialanalyse
subject: Hörsehverstehen
subject: Nachrichten
classificationCode: 440
subject: Romanische Sprachen; Französisch
classificationCode: 373
subject: Sekundarbildung
classificationCode: 791
subject: Öffentliche Darbietungen, Film, Rundfunk

description: DIe Fragestellung grenzt den Bereich der bisher recht wenig erforschten Verwendung von Nachrichten im Fremdsprachenunterricht dahingehend ein, dass eine Kindernachtrichtensendung (Arte Journal Junior) und deren Verwendung für Französischlernende der ersten beiden Lernjahre (innerhalb der Sek. I) untersucht werden. Die Sendung stellt eine authentische Ressource dar, deren Eigenschaften und Vorteile zu Beginn erläutert werden. Hierzu zählen eine Steigerung der Motivation, eine Gewöhnung an authentisches sprachliches Material und die Verwendung der Sprache in einem Kontext, der nicht an das Klassenzimmer gebunden ist. Charakteristika des Anfangsunterrichts werden ebenso erläutert wie der historische Hintergrund des ausgewählten Senders. Es schließt sich die Analyse der Sendung insgesamt und der einzelnen näher untersuchten Folgen an. Diese findet anhand der Untersuchungskriterien Inhalt, Bild, Ton und Bild-Ton-Zusammenspiel statt. Aus den ausgewählten Folgen des "Journal Junior" werden Einsatzmöglichkeiten für den Unterricht abgeleitet. Bei einer Nachrichtensendung bietet sich die Schulung des Hörsehverstehens mit allen zugehörigen Teilbereichen an (globales, detailliertes, selektives aber auch ästehtisches und inferierendes HSV). Des Weiteren lassen sich anhand der Sendung der Strategiengebrauch einüben sowie weitere fremdsprachenspezifische und fächerübergreifende Kompetenzen erwerben und erweitern: Interkulturelle kommunikative Kompetenz, Medienkompetenz sowie Sprachlernkompetenz in Form von Lernerautonomie.
Drosophila martensis Wasserman & Wilson 1957
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila martensis

description: martensis Wasserman & Wilson, 1957: 151. Type locality: Colombia, Santa Marta. HT M (USNM). NT Distr.: Colombia (La Guajira (Riohacha: Camarones), Magdalena (Santa Marta), Huila (Desierto de la Tatacoa: Rosalia)), Venezuela, West Indies. Refs.: De Polanco, et al., 2008: 106.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 728, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Glaucostegus Bonaparte 1846
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Rajiformes
Rhinobatidae
Glaucostegus

description: Genus Glaucostegus Bonaparte, 1846
Giant Guitarfishes
Glaucostegus Bonaparte, 1846: 14. Type species Rhina cemiculus Geoffrey St. Hilaire, 1827, by subsequent designation by Jordan & Evermann, 1896: 61 as Rhina rhinobatos Shaw = Rhina cemiculus Geoffroy.
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 49, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
title: Vibrant Matter in the Performative Apparatus: Sound, Bodies and Movement in Stefanie Egedy’s “BODIES AND SUBWOOFERS (B.A.S.)” and Doris Uhlich’s “TANK”
Creators: name: Alf, Stefanie
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: vibrant matter
subject: performative apparatus
subject: Doris Uhlich
subject: Stefanie Egedy
subject: intra-action
subject: resonances in human and non-human bodies
subject: post-performativity
classificationCode: 701
subject: Kunstphilosophie, Kunsttheorie der bildenden und angewandten Kunst

description: This thesis explores the intra-action of sound, bodies and movement in performative works, focusing on Stefanie Egedy’s BODIES AND SUBWOOFERS (B.A.S.) and Doris Uhlich’s TANK. Drawing on critical dance studies, sound studies, and material culture theories, it examines how vibrant matter resonates in human and non-human bodies inside the performative apparatus. In B.A.S. Egedy creates site-specific subwoofer set-ups with sub-bass frequencies that set human and non-human bodies into vibration. Uhlich’s TANK is a solo performance within a glass tank in collaboration with Boris Kopeinig’s electronic music. It interrogates bodily transformations and their material-discursive interrelations. Through a mixed methodology combining discourse and phenomenological analysis, the thesis applies Jane Bennett’s Vibrant Matter and Karen Barad’s “Posthumanist Performativity: Toward an Understanding of How Matter Comes to Matter” to investigate how sound and movement intra-act with human and non-human bodies in space and create the audience’s experience. Field research, audience quotes, and a phenomenological analysis of B.A.S. and TANK enrich the analysis, revealing that both works challenge traditional boundaries between performer, sound, audience, and space. Ultimately, the research contributes to a deeper understanding of the relational dynamics in contemporary performative arts, showing how performative works can transform audience perception of bodies, space and sound.