title: ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÐ¸ÑÐ¾ÐºÐ¸Ð½Ð¾Ð²Ð¾Ð³Ð¾ Ð¿ÑÐ¾ÑÐ¸Ð»Ñ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ñ Ð´Ð¸Ð°Ð³Ð½Ð¾Ð·Ð¾Ð¼ ÑÐ²ÐµÐ½Ð¸Ð»ÑÐ½Ð¾Ð³Ð¾ Ð¸Ð´Ð¸Ð¾Ð¿Ð°ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð°ÑÑÑÐ¸ÑÐ°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Study of the cytokine profile of patients diagnosed with juvenile idiopathic arthritis
Creators: name: Ð ÑÐ±Ð°ÐºÐ¾Ð², ÐÑÑÐµÐ½Ð¸Ð¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2023
Subjects: Ð°ÑÑÐ¾Ð¸Ð¼Ð¼ÑÐ½Ð½ÑÐµ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ñ
ÑÐ²ÐµÐ½Ð¸Ð»ÑÐ½ÑÐ¹ Ð¸Ð´Ð¸Ð¾Ð¿Ð°ÑÐ¸ÑÐµÑÐºÐ¸Ð¹ Ð°ÑÑÑÐ¸Ñ
ÑÐ¸ÑÐ¾ÐºÐ¸Ð½Ñ
Ð³Ð¾ÑÐ¼Ð¾Ð½Ñ
Ð¿ÐµÑÑÐ¿ÐµÐºÑÐ¸Ð²Ð½ÑÐµ Ð¼Ð°ÑÐºÐµÑÑ Ð´Ð»Ñ Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÐºÐ¸ Ð°ÑÑÐ¾Ð¸Ð¼Ð¼ÑÐ½Ð½ÑÑ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ð¹
autoimmune diseases
juvenile idiopathic arthritis
cytokines
hormones
promising markers for the diagnosis of autoimmune diseases

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸Ñ ÑÐ¸ÑÐ¾ÐºÐ¸Ð½Ð¾Ð² (ÐÐ-1Î±, 1Ã, 2, 3, 4, 5, 6, 7, 8, 10, 12, 13, 15, 17Ð, 18, 22, 27), ÑÐµÐ¼Ð¾ÐºÐ¸Ð½Ð¾Ð² (MCP-1, MCP-3, MCSF, MDC, MIG, RANTES), ÑÑÐ´Ð° Ð³Ð¾ÑÐ¼Ð¾Ð½Ð¾Ð² (ÑÐµÑÑÐ¾ÑÑÐµÑÐ¾Ð½, ÐºÐ¾ÑÑÐ¸Ð·Ð¾Ð», Ð¿ÑÐ¾Ð³ÐµÑÑÐµÑÐ¾Ð½, ÑÑÑÑÐ°Ð´Ð¸Ð¾Ð», ÑÐ¸ÑÐ¾ÐºÑÐ¸Ð½ Ð¸ ÑÑÐ¸Ð¹Ð¾Ð´ÑÐ¸ÑÐ¾Ð½Ð¸Ð½), Ð° ÑÐ°ÐºÐ¶Ðµ Ð¿ÐµÑÑÐ¿ÐµÐºÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¼Ð°ÑÐºÐµÑÐ° - Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ Ð±ÑÑÐ¸ÑÐ¸Ð»ÑÐ¾Ð»Ð¸Ð½ÑÑÑÐµÑÐ°Ð·Ñ Ð² Ð¿Ð»Ð°Ð·Ð¼Ðµ ÐºÑÐ¾Ð²Ð¸ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ñ Ð´Ð¸Ð°Ð³Ð½Ð¾Ð·Ð¾Ð¼ ÑÐ²ÐµÐ½Ð¸Ð»ÑÐ½Ð¾Ð³Ð¾ Ð¸Ð´Ð¸Ð¾Ð¿Ð°ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð°ÑÑÑÐ¸ÑÐ°. Ð ÑÐ°Ð±Ð¾ÑÐµ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¾ ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸Ðµ Ð²ÑÐµÑ Ð²ÑÑÐµÐ¿ÐµÑÐµÑÐ¸ÑÐ»ÐµÐ½Ð½ÑÑ Ð¼Ð°ÑÐºÐµÑÐ¾Ð², Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÐµ Ð·Ð½Ð°ÑÐµÐ½Ð¸Ñ ÑÑÐ°Ð²Ð½Ð¸Ð²Ð°Ð»Ð¸ÑÑ Ð¼ÐµÐ¶Ð´Ñ Ð¸ÑÑÐ»ÐµÐ´ÑÐµÐ¼Ð¾Ð¹ Ð³ÑÑÐ¿Ð¿Ð¾Ð¹ Ð¸ Ð³ÑÑÐ¿Ð¿Ð¾Ð¹ ÑÑÐ»Ð¾Ð²Ð½Ð¾ Ð·Ð´Ð¾ÑÐ¾Ð²ÑÑ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð², Ð½Ðµ Ð¸Ð¼ÐµÑÑÐ¸Ñ Ð°ÑÑÐ¾Ð¸Ð¼Ð¼ÑÐ½Ð½ÑÑ Ð¿Ð°ÑÐ¾Ð»Ð¾Ð³Ð¸Ð¹ Ð² Ð°Ð½Ð°Ð¼Ð½ÐµÐ·Ðµ. ÐÐ°Ð½Ð½ÑÐµ Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ñ Ð² Ð²Ð¸Ð´Ðµ Ð³ÑÐ°ÑÐ¸ÐºÐ¾Ð² Ð¸ ÑÐ°Ð±Ð»Ð¸Ñ. ÐÑÐ½Ð¾Ð²Ð½ÑÐµ Ð¼ÐµÑÐ¾Ð´Ñ, Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð½ÑÐµ Ð² Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ: ÑÐ²ÐµÑÐ´Ð¾ÑÐ°Ð·Ð½ÑÐ¹ Ð¸Ð¼Ð¼ÑÐ½Ð¾ÑÐµÑÐ¼ÐµÐ½ÑÐ½ÑÐ¹ Ð°Ð½Ð°Ð»Ð¸Ð· Ð¸ ÐµÐ³Ð¾ Ð¼Ð¾Ð´Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¸, Ð¼ÐµÑÐ¾Ð´ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ñ ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²Ð° Ð±ÐµÐ»ÐºÐ° Ð² Ð¿ÑÐ¾Ð±Ðµ Ñ Ð±Ð¸ÑÐ¸Ð½ÑÐ¾Ð½Ð¸Ð½Ð¾Ð²Ð¾Ð¹ ÐºÐ¸ÑÐ»Ð¾ÑÐ¾Ð¹, Ð¼Ð¾Ð´Ð¸ÑÐ¸ÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐ¹ Ð¼ÐµÑÐ¾Ð´ Ð­Ð»Ð»Ð¼Ð°Ð½Ð° Ð´Ð»Ñ Ð¸Ð·Ð¼ÐµÑÐµÐ½Ð¸Ñ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð±ÑÑÐ¸ÑÐ¸Ð»ÑÐ¾Ð»Ð¸Ð½ÑÑÑÐµÑÐ°Ð·Ñ.
description: This work is devoted to the study of the content of cytokines (IL-1Î±, 1Ã, 2, 3, 4, 5, 6, 7, 8, 10, 12, 13, 15, 17A, 18, 22, 27), chemokines (MCP-1, MCP-3, MCSF, MDC, MIG, RANTES), a number of hormones (testosterone, cortisol, progesterone, estradiol, thyroxine and triiodothyronine), as well as a group of promising diagnostic markers (calprotectin, butyrylcholinesterase activity) in the blood plasma of patients diagnosed with juvenile idiopathic arthritis. In the work, the content of all the above markers in the blood plasma was determined, the obtained values were compared between the study group and the group of healthy patients with no history of autoimmune pathologies. The data are presented in the form of graphs and tables. The main methods used in this work: enzyme-linked immunosorbent assay and its modifications, a method for determining the amount of protein in a sample with bicinchoninic acid, a modified Ellmanâs method for measuring butyrylcholinesterase activity.