cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Cyclocephala rustica
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala rustica

description: Cyclocephala rustica (Olivier, 1789)
Melolontha rustica Olivier 1789: 27 (Trinidad and Tobago)
= Cyclocephala rustica municipalis Höhne 1923b: 365 (Venezuela - LECTOTYPE)
Distribution. Suriname: Uyttenboogaart 1902: 116; Moore et al. 2018b: 242; MHCN; NZCS. French Guiana: Endrödi 1966a: 299 (as C. rustica municipalis; as C. rustica rustica (?)), 1985a: 35, 116 (Guyana [> Fr. Guiana] - as C. rustica municipalis); Duranton 2011: 15; Ponchel 2011: 60; Dupuis 2016b: 109; Moore et al. 2018b: 242. “Guianas”: Höhne 1923b: 365; Arrow 1937b: 15; Blackwelder 1944: 252. Brazil (NA): Höhne 1923b: 365 (as C. rustica municipalis); Endrödi 1966a: 299 (as C. rustica municipalis) (NA); Endrödi 1985a: 35, 116 (as C. rustica municipalis); Moore et al. 2018b: 242. Venezuela: Höhne 1923b: 365 (as C. rustica municipalis); Endrödi 1966a: 299 (designation LECTOTYPE Cyclocephala rustica municipalis); Endrödi 1985a: 35, 116 (as C. rustica municipalis); Moore et al. 2018b: 242. Other: Olivier 1789: 27 (Guadeloupe); Höhne 1923b: 365 (Colombia, Mexico - as C. rustica municipalis; Trinidad and Tobago - as C. rustica rustica); Blackwelder 1944: 252 (Guadeloupe); Endrödi 1966a: 299 (Colombia, Mexico, Peru - as C. rustica municipalis; Guadeloupe, Trinidad and Tobago - designation NEOTYPE Melolontha rustica), 1985a: 35, 116 (Colombia, Mexico, Peru - as C. rustica municipalis; Guadeloupe, Trinidad and Tobago - as C. rustica rustica); Moore et al. 2018b: 242 (Colombia, Peru, Trinidad and Tobago).
Note 1. Moore et al. (2018b: 107) conclude that the neotype of Melolontha rustica designated in Endrödi (1966a: 299) is invalid because it violates several demands of Article 75 of the ICZN (1964: 81).
Note 2. Olivier (1789: 27) describes Cyclocephala rustica from Guadeloupe, and this record is copied in Blackwelder (1944: 252) and Endrödi (1966a: 299, 1985a: 35, 116). However, Ratcliffe and Cave (2015: 291), addressing just Endrödi (1966a), claim this record is incorrect, as C. rustica is a South American species. Olivier’s type specimen may be mislabeled.
Note 3. In Endrödi (1966a: 299), both Cyclocephala rustica rustica and C. rustica municipalis are reported from “Guayana: Cayenne,” which is French Guiana. In Endrödi (1985a: 35) Guyana, but not French Guiana, is mentioned for C. rustica municipalis (with C. rustica rustica only being mentioned for the Antilles). As all more specific locations were omitted in the 1985 publication, we assume the remaining “Guayana” erroneously became Guyana. We are unaware of actual records of this species from Guyana.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 180, DOI: 10.5281/zenodo.3678492
Vom Riedstöckli 1840 mt unter d. Ortstock
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1877

description: [Johann Müller Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Effects of stimulation on intracellular calcium in frog sartorius muscle
Creators: name: Webb, Jerry Glen
Publisher: name: University of Utah
Year: 2012
Subjects: Metabolism
Pharmacokinetics

description: The cellular state and distribution of calcium were investigated in frog sartorius muscle at rest and following periods of stimulation.  The purpose of the experiments was to define the relative importance of the various cell organelles in the regulation of intracellular calcium.  Stimulation increased 45CA uptake by whole muscle and decreased the rate of exchange of cellular calcium in washout experiments.  The change in washout characteristics appeared to be the results of a shift of 45Ca from rapidly exchanging to a slowly exchanging pool of cellular calcium.  The effect of stimulation on the subcellular distribution 45Ca and calcium was studied by differential centrifugation.  The data revealed a heterogeneous distribution of the intracellular calcium, with the highest concentrations in the mitochondrial, heavy reticular, and microsomal fractions.  In resting muscle, mitochondria accounted for about 25% of the total tissue 45Ca; however, in stimulated preparations over 40% of the 45Ca was recovered in this fraction.  The increase in radioactivity is the consequence of accelerated turnover because stimulation produced little change in the subcellular distribution of total calcium.  The relatively profound effect of stimulation on mitochondrial calcium exchange suggests that this organelle plays a role in the movements of intracellular calcium associated with the cycle of contraction and relaxation in skeletal muscle.
Computational methods for investigating intradriver heterogeneity using vehicle trajectory data
Creators: name: Taylor, Jeffrey D.
Publisher: name: University of Utah
Year: 2014
Subjects: Car following model
Driver behavior
Dynamic time warping
Heterogeneity
NGSIM

description: Traffic simulations, which attempt to describe how individual vehicles move on road segments in a network, rely on mathematical traffic flow models developed from empirical vehicle trajectory data (position, speed, acceleration, etc.). Many of these microscopic traffic flow models are described as car-following models, which assume that a driver will respond to the actions of the driver/s or vehicle/s located in front of them (stimulus-response behavior). Model calibration can be performed using regression and/or optimization techniques, but the process is often complicated by uncertainty and variation in human behavior, which can be described as driver heterogeneity. Driver heterogeneity is conceptually based on the idea that different drivers may have different reactions to the same stimuli (interdriver heterogeneity), and an individual driver may react differently to the same type of stimulus (intradriver heterogeneity). To capture interdriver heterogeneity, car-following model parameters must be estimated for each driver/vehicle in the dataset, which are then used to describe a probability distribution associated with those model parameters. Capturing intradriver heterogeneity requires going one step further, calculating those same model parameters over much smaller time periods (i.e., seconds, or fractions of sections) within one vehicle's trajectory. This significantly reduces the amount of data available for calibration, limiting the ability to use traditional calibration procedures.
Gebirgsansicht von ob Sulz bey Ober Fritteren Stafel (ob dem Urner Boden)
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1877

description: [Johann Müller Wegmann]
description: Unterhalb des Titels Hinweis: "NB den Langfirn um Gemsfayren sieht man in Zürich vor dem Biffertenstock die Teufelsstöck vor dem Tödi ebenso den Rothnassen"
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Use of Family History to Improve Risk Prediction in Clinical Care: Colorectal Cancer as an Example
Creators: name: Taylor, David P.
Publisher: name: University of Utah
Year: 2014

description: Family history has been called the "cornerstone of individualized disease prevention" but it is underutilized in clinical practice. In order to use it more effectively, its role in assessing risk for disease needs to be better quantified and understood. Family history has been identified as an important risk factor for colorectal cancer (CRC) and risk prediction in CRC is potentially worthwhile because of the possibility of preventing the disease through application of individualized screening programs tailored to risk. The overall project objective was to explore how family history can be better utilized to predict who will develop CRC. First, we used the Utah Population Database (UPDB) to define familial risk for CRC in more detail than has previously been reported. Second, we explored whether individuals at increased familial risk for CRC or at increased risk based on other risk factors such as a personal history of CRC or adenomatous polyps, are more compliant with screening and surveillance recommendations using colonoscopy than those who are at normal risk. Third, we measured how well family history can predict who will develop CRC over a period of 20 years, using family history by itself as a risk factor, and also in combination with the risk factor, age. We found that increased numbers of affected first-degree relatives influence risk much more than affected relatives from the second or third degrees. However, when combined with a positive firstdegree family history, a positive second- and third-degree family history can significantly increase risk. Next, we found that colonoscopy rates were higher in those with risk factors, according to risk-specific guidelines, but improvements in compliance are still warranted. Lastly, it was determined that family history by itself is not a strong predictor of exactly who will acquire colorectal cancer within 20 years. However, stratification of risk using absolute risk probabilities may be more helpful in focusing screening on individuals who are more likely to develop the disease. Future work includes using these findings as a basis for a cost/benefit analysis to determine optimal screening recommendations and building tools to better capture and utilize family history data in an electronic health record system.
Novel oxindole/benzofuran hybrids as potential dual CDK2/GSK-3β inhibitors targeting breast cancer: design, synthesis, biological evaluation, and in silico studies
Creators: name: Eldehna, Wagdy M.
name: Al-Rashood, Sara T.
name: Al-Warhi, Tarfah
name: Eskandrani, Razan O.
name: Alharbi, Amal
name: Kerdawy, Ahmed M. El
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Inorganic Chemistry
subject: Hematology

description: The serine/threonine protein kinases CDK2 and GSK-3β are key oncotargets in breast cancer cell lines, therefore, in the present study three series of oxindole-benzofuran hybrids were designed and synthesised as dual CDK2/GSK-3β inhibitors targeting breast cancer (5a–g, 7a–h, and 13a–b). The N1-unsubstituted oxindole derivatives, series 5, showed moderate to potent activity on both MCF-7 and T-47D breast cancer cell lines. Compounds 5d–f showed the most potent cytotoxic activity with IC50 of 3.41, 3.45 and 2.27 μM, respectively, on MCF-7 and of 3.82, 4.53 and 7.80 μM, respectively, on T-47D cell lines, in comparison to the used reference standard (staurosporine) IC50 of 4.81 and 4.34 μM, respectively. On the other hand, the N1-substituted oxindole derivatives, series 7 and 13, showed moderate to weak cytotoxic activity on both breast cancer cell lines. CDK2 and GSK-3β enzyme inhibition assay of series 5 revealed that compounds 5d and 5f are showing potent dual CDK2/GSK-3β inhibitory activity with IC50 of 37.77 and 52.75 nM, respectively, on CDK2 and 32.09 and 40.13 nM, respectively, on GSK-3β. The most potent compounds 5d–f caused cell cycle arrest in the G2/M phase in MCF-7 cells inducing cell apoptosis because of the CDK2/GSK-3β inhibition. Molecular docking studies showed that the newly synthesised N1-unsubstituted oxindole hybrids have comparable binding patterns in both CDK2 and GSK-3β. The oxindole ring is accommodated in the hinge region interacting through hydrogen bonding with the backbone CO and NH of the key amino acids Glu81 and Leu83, respectively, in CDK2 and Asp133 and Val135, respectively, in GSK-3β. Whereas, in series 7 and 13, the N1-substitutions on the oxindole nucleus hinder the compounds from achieving these key interactions with hinge region amino acids what rationalises their moderate to low anti-proliferative activity.
Cyclocephala sarahae Ratcliffe 1992
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala sarahae

description: § Cyclocephala sarahae Ratcliffe, 1992
Cyclocephala sarahae Ratcliffe 1992: 187 (Brazil (NA))
Distribution. Brazil (NA): Ratcliffe 1992: 187 (NA); Joly 2009: 59 (NA); Moore et al. 2018b: 244.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 180, DOI: 10.5281/zenodo.3678492
Die  obere Baumgartenalp von Süd West 1736 mt
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1877

description: [Johann Müller Wegmann]
description: Am unteren Blattrand Hinweis: "L.B. ist eine grosse massive Mauer ein sog. Lawinenbrecher"
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Construction of 2-ADIC Galois extension with wild inertia given by an extra special 2-group
Creators: name: Kocs, Christopher
Publisher: name: University of Utah
Year: 2012
Subjects: 2-adic field extensions
Clifford algebra
Elliptic curve
Extra special 2-group
Galois theory
Quadratic forms

description: Given any field F and an odd integer n, suppose K be a degree 2n1 multiquadratic extension of F. We consider the conditions under which there is a Galois extension E of F such that Gal(E/F) is a particular extra special 2-group T0 { namely, the multiplicative group generated by basis elements of the even Clifford algebra associated with the quadratic form X2 1 + ::: + X2 n. These conditions can be restated in terms of the Weil index, which can be computed explicitly as a Gauss sum when F = Q2n. We prove an equidistribution of Gauss sums for quadratic characters on Q2n of conductor 4Z2n. As a consequence, we prove that, when n is an odd prime greater than 3, there exists a Galois extension K of Q2 such that K is a multiquadratic extension of Q2n that admits a quadratic extension E such that Gal(E/F) = T0.
Effect of programmed heating on yields and oil quality in retorting of Green River oil shale
Creators: name: Fischer-Calderon, Pedro Ernesto
Publisher: name: University of Utah
Year: 2012
Subjects: Shale oils, refining

description: Three large blocks of oil shale from the Hell's Hole Canyon outcrop were selected and graded with Fischer assay at 18, 45 and 73 US gal/ton. Smaller cubes with similar bedding planes were cut from these blocks, with side dimensions of around 0.12 m. These cubes were heated under a nitrogen atmosphere, with constant heating rates of 2, 1, and 0.5°C/min, respectively, from ambient temperature up to 600°C. Two additional runs were performed for each block holding the temperature constant for 24 hours at 200°C and 300°C (soaking conditions).  In all cases the liquids collected during the retorting process had a higher hydrogen to carbon ratio (1.7 to 1.8) at the beginning of the runs than near their end (1.35 to 1.6). Their nitrogen content increased from 1.5 to 1.8 weight percent initially to 3 to 3.8 weight percent at the end of the runs. For the 200°C soaking condition the oil produced was lighter (i.e., lower density and better yield of lower boiling point components) than the oil prod
Single copy replication control is regulated by genes involved in ubiquitin metabolism in the yeast Saccharomyces cerevisiae
Creators: name: Singer, Jeffrey D.
Publisher: name: University of Utah
Year: 2012
Subjects: DNA Replication
Ubiquitin

description: DNA replication is limited to only once per cell cycle in eukaryotic cells. A model proposed by Ron Laskey and Julian Blow to explain how cells accomplish this is called the licensing factor model. In this model they propose the existence of an entity that must be present to allow DNA to be replicated, and that is inactivated until the next cell cycle by the passing DNA replication fork. In order to identify potential inhibitors of re-replication a genetic screen was developed in the yeast Saccharomyces cerevisiae that is based on the idea that if a cell contained a temperature sensitive allele of such an inhibitor it would make too much DNA at the restrictive temperature and that this would be lethal. This lethality should, however, be circumvented by a second mutation in DNA polymerase that blocks DNA synthesis at the high temperature. A mutation was identified using this screen that was sensitive to high copy numbers of the POL1 gene but was rescued by a temperature sensitive allele of this gene, cdc17-1. Cells with this mutation also have elevated DNA contents including cells with greater than a 2C DNA content; thus the mutation was named dos1-1 for DNA over synthesis. The mutation was found to be a single base deletion in a gene called DOA4 which encodes a ubiquitin hydrolase, an enzyme involved in the ubiquitin dependent proteolytic pathway. Further analysis of this mutation revealed that it displays many of phenotypes seen in mutations that disturb DNA metabolism such as elevated chromosome loss and a large percentage of large budded cells with a single nucleus at the neck of the bud. Analysis of ubiquitin pools revealed that at high temperature the cells were deficient in free ubiquitin. Consistent with this, another gene involved in ubiquitin metabolism, UBI4, was identified as a single copy suppressor of the temperature sensitivity of dos1-1. In addition, double mutants lacking both DOA4 and UBI4 have decreased viability which implies that they are involved in parallel pathways essential for growth. The data reported in this thesis indicate a direct link between single copy control of DNA replication in eukaryotic cells and ubiquitin metabolism.
Cyclocephala sardadebiae Dechambre and Duranton 2005
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala sardadebiae

description: Cyclocephala sardadebiae Dechambre and Duranton, 2005
Cyclocephala sardadebiae Dechambre and Duranton 2005: 68 (French Guiana)
Distribution. French Guiana: Dechambre and Duranton 2005: 68; Ponchel 2011: 60; Dupuis 2016b: 109; Moore et al. 2018b: 244.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 180, DOI: 10.5281/zenodo.3678492
Die  obere Baumgartenalp von Nord Ost 1736 mt
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1877

description: IM
description: Am unteren Blattrand Hinweis: "L.B. Lawinenbrecher massive Mauer"
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Evaluation of the economic feasability of heavy oil production processes for West Sak Field
Creators: name: Wilkey, Jonathan E.
Publisher: name: University of Utah
Year: 2012
Subjects: West Sak Field

description: The West Sak heavy oil reservoir on the North Slope of Alaska represents a large potential domestic oil source which has not been fully developed due to difficulties with producing viscous oil from a cold reservoir. Past studies have evaluated the economic viability of producing from West Sak, but given the rising demand for oil, a fresh evaluation of the economic feasibility of heavy oil production processes from West Sak is warranted. Therefore, the objective of this project was to design a set of possible processes for recovery of heavy oil from West Sak and identify any economic barriers to production. Discounted cash flows were used to determine the investor's rate of return (IRR) for each process assuming oil sold for either a fixed price or followed a given price forecast. Capital and operating costs were estimated primarily using the methodology suggested by Seider et al. (2008). Three different scenarios were analyzed using this methodology: a base case and two alternatives for oil transport (dilution with gas-to-liquids and upgrading via hydrotreating). Polymer flooding was selected as the recovery method for all scenarios and production rates were estimated from recovery curves published by Seright (2011). Each scenario also investigates the possibility of using oxy-firing for CO2 capture as an alternative method for providing process heating. Results of the economic analysis show that the base case would produce an IRR of 41% (dilution would produce a 45% IRR, and upgrading a 6% IRR). A sensitivity analysis performed on the model's inputs gave a range of possible IRRs for the base case of 30% to 50%, dilution's range was 24% to 62%, and upgrading ranged from -2% to 29%. Both the base case and dilution scenarios have no economic barriers to development. If West Sak heavy oil as produced can be delivered via pipeline, then the base case would be the economically preferable scenario. Upgrading is not economically feasible due to high capital costs which drive up the required oil price and result in large severance tax liabilities.
Utility of novel 2-furanones in synthesis of other heterocyclic compounds having anti-inflammatory activity with dual COX2/LOX inhibition
Creators: name: El-Hameed, Rania H. Abd
name: Mahgoub, Shahenda
name: El-Shanbaky, Hend M.
name: Mohamed, Mosaad S.
name: Ali, Sahar A.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Inflammation is associated with the development of several diseases comprising cancer and cardiovascular disease. Agents that suppress cyclooxygenase (COX) and lipoxygenase (LOX) enzymes, besides chemokines have been suggested to minimise inflammation. Here, a variety of novel heterocyclic and non-heterocyclic compounds were prepared from novel three furanone derivatives. The structures of all synthesised compounds were confirmed by elemental and spectral analysis including mass, IR, and 1H-NMR spectroscopy. Anti-inflammatory activities of these synthesised compounds were examined in vitro against COX enzymes, 15-LOX, and tumour necrosis factor-α (TNF-α), using inhibition screening assays. The majority of these derivatives showed significant to high activities, with three pyridazinone derivatives (5b, 8b, and 8c) being the most promising anti-inflammatory agents with dual COX-2/15-LOX inhibition activities along with high TNF-α inhibition activity.
Case study of two complex health care institutions with charging systems for nursing care
Creators: name: Kee, Helen Klutcher
Publisher: name: University of Utah
Year: 2012
Subjects: Economics
Nursing Services
Reimbursement Mechanisms

description: A descriptive, case study design was used to describe specific aspects of two complex health care institutions that have charging systems for nursing care. The sample from each institution included the director of nursing services, associate/assistant directors of nursing services, 4 head nurses representing the major medical services provided by the institutions, the hospital administrator, the associate/assistant administrators, the chief financial officer and the assistant financial officer, for a total of 26 interviewees. The questions for the interviews were structured for each category of interviewees. These questions elicited responses pertaining to the organizational authority structure, span of control, financial system, patient care systems, nurse staffing methodology, patient classification system, and various belief issues about charging for nursing care. The data were analyzed and related to each research question for each group of interviewees. Additional data from written materials were used to describe the study organizations. The research questions were: (1) What are the organizational characteristics of the two complex health care institutions in which nursing care is charged for discretely? (2) What are the characteristics of the nursing department in the two complex health care institutions where the nursing budget is separated from the general hospital budget? (3) How are charges for nursing care identified so as to reflect not only nursing care expenses, but also revenue generated by the nursing department? The conclusions were that both study organizations have traditional organizational structure following the bureaucratic model. Both hospitals and the nursing departments within these hospitals utilized a system of hierarchy of authority, functional divisions of labor, formalized rules and practices with centralized major decision making and decentralized daily operational decisions. Both nursing departments utilized a patient classification system for data collection for the charging for nursing care system. The two organizations differ in their basic goals, governance structure and numbers of administrative staff of authority. The results of this study demonstrate that both hospitals were able to design and implement a system of charging for nursing care within their organizational structure, despite differences between these structures.
New 3-O-substituted xanthone derivatives as promising acetylcholinesterase inhibitors
Creators: name: Loh, Zi Han
name: Kwong, Huey Chong
name: Lam, Kok Wai
name: Teh, Soek Sin
name: Ee, Gwendoline Cheng Lian
name: Quah, Ching Kheng
name: Ho, Anthony Siong Hock
name: Mah, Siau Hui
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: A new series of 3-O-substituted xanthone derivatives were synthesised and evaluated for their anti-cholinergic activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The results indicated that the xanthone derivatives possessed good AChE inhibitory activity with eleven of them (5, 8, 11, 17, 19, 21-23, 26-28) exhibited significant effects with the IC50 values ranged 0.88 to 1.28 µM. The AChE enzyme kinetic study of 3-(4-phenylbutoxy)-9H-xanthen-9-one (23) and ethyl 2-((9-oxo-9H-xanthen-3-yl)oxy)acetate (28) showed a mixed inhibition mechanism. Molecular docking study showed that 23 binds to the active site of AChE and interacts via extensive π–π stacking with the indole and phenol side chains of Trp86 and Tyr337, besides the hydrogen bonding with the hydration site and π–π interaction with the phenol side chain of Y72. This study revealed that 3-O-alkoxyl substituted xanthone derivatives are potential lead structures, especially 23 and 28 which can be further developed into potent AChE inhibitors.
Die  Schäferhütte auf Nüschenalp 2217 mt am Kistenpass
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1877

description: [Johann Müller Wegmann]
description: Am unteren Blattrand Hinweis: "NB man muss gebückt in die Hütte treten und und darf man sich die Felsen noch etwas grösser denken"
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Anti-influenza A virus activity and structure–activity relationship of a series of nitrobenzoxadiazole derivatives
Creators: name: Fiorentino, Francesco
name: De Angelis, Marta
name: Menna, Martina
name: Rovere, Annarita
name: Caccuri, Anna Maria
name: D’Acunzo, Francesca
name: Palamara, Anna Teresa
name: Nencioni, Lucia
name: Rotili, Dante
name: Mai, Antonello
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Influenza viruses represent a major threat to human health and are responsible for seasonal epidemics, along with pandemics. Currently, few therapeutic options are available, with most drugs being at risk of the insurgence of resistant strains. Hence, novel approaches targeting less explored pathways are urgently needed. In this work, we assayed a library of nitrobenzoxadiazole derivatives against the influenza virus A/Puerto Rico/8/34 H1N1 (PR8) strain. We identified three promising 4-thioether substituted nitrobenzoxadiazoles (12, 17, and 25) that were able to inhibit viral replication at low micromolar concentrations in two different infected cell lines using a haemagglutination assay. We further assessed these molecules using an In-Cell Western assay, which confirmed their potency in the low micromolar range. Among the three molecules, 12 and 25 displayed the most favourable profile of activity and selectivity and were selected as hit compounds for future optimisation studies.
MPEC 2025-H86 : COMET P/2017 FL36 (PANSTARRS)
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2025
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: COMET P/2017 FL36 (PANSTARRS)

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Eckstöcke von den Auengütern gesehen
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1877

description: Die Eggstöck von Auengüeter, südlich von Linthal, aus gesehen
description: [Johann Müller Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Computer-generated reminder system for diabetes preventive care
Creators: name: Nilasena, David Shaw
Publisher: name: University of Utah
Year: 2012
Subjects: Treatment
Computer Programs

description: Diabetes mellitus is a chronic condition with several late complications that can be avoided through proper preventive health care. Although practice guidelines have been established to improve preventive care in diabetics, dissemination of these guidelines has been only moderately successful in changing physicians' practice patterns. The effectiveness of computerized reminders for diabetes preventive care has not been widely studied.  We developed a computer-generated reminder system for diabetes care guidelines and implemented it in a randomized controlled study in the outpatient clinics of 35 medical residents. The system successfully flagged items that deviated from guideline recommendations. The residents completed encounter forms used by the system for 37% of patients seen during a six month study period. During this period, compliance with the guidelines significantly improved in both the intervention group that received patient-specific guideline reminders (38.0% at baseline, 54.9% at follow-up) and the control group that received a nonspecific report (34.6% at baseline, 51.0% at follow-up). There was no significant difference between the two groups. Residents who completed encounter forms showed a significantly greater improvement in compliance than those who did not complete forms (19.7% vs. 7.6%, p=0.006). The improvements in guideline compliance were seen in all areas of diabetes preventive care studied. The use of encounter forms by the providers significantly improved documented compliance with the guidelines in almost all categories of preventive care. Physician users exhibited positive attitudes toward the use of guidelines. However, the complexity and length of the encounter forms and the additional time demands proved to be significant obstacles to routine use. These results suggest that computerized reminder systems improve compliance with recommended care more by facilitating the documentation of clinical findings and the ordering of recommended procedures than by providing the clinician with patient-specific information about guideline compliance status. Successful reminder systems must be easy to use and have goals that are understood and accepted by the users. These findings may help improve the design and development of other computerized reminder systems for chronic diseases such as diabetes, especially in the future as health care increasingly makes use of electronic medical record systems.
Cyclocephala sarpedon Ratcliffe 1992
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala sarpedon

description: Cyclocephala sarpedon Ratcliffe, 1992
Cyclocephala sarpedon Ratcliffe 1992: 188 (Brazil)
Distribution. Suriname: Ratcliffe 1992: 188; Moore et al. 2018b: 245. Brazil: Ratcliffe 1992: 188; Moore et al. 2018b: 245. Venezuela: Ratcliffe 1992: 188; Moore et al. 2018b: 245.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 181, DOI: 10.5281/zenodo.3678492
title: Memoria 2010
Creators: name: Universidad Especializada de las Américas, UDELAS
Publisher: name: Universidad Especializadas de las Américas
Year: 2019
Subjects: subject: FOS: Educational sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: La realización de un sueño: en la aurora del décimo tercer año de su fundación, la Universidad Especializada de las Américas (UDELAS)muestra que los principios originarios que le dieron vida a su proyecto presentan actualmente frutos evidentes en la docencia, la investigación, la extensión y la gestión. Estos resultados son convergentes con la proyección y el compromiso social que coloca a la persona humana en el centro de sus preocupaciones y actuaciones institucionales.
Cyclocephala schmitzorum Ratcliffe 1992
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala schmitzorum

description: Cyclocephala schmitzorum Ratcliffe, 1992
Cyclocephala schmitzorum Ratcliffe 1992: 189 (Brazil)
Distribution. Suriname: Ratcliffe 1992: 189; Moore et al. 2018b: 245. Brazil (NA): Ratcliffe 1992: 189 (NA); Moore et al. 2018b: 245.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 181, DOI: 10.5281/zenodo.3678492
Study of some factors affecting stability in a nonaqueous emulsion
Creators: name: Hamill, Richard David
Publisher: name: University of Utah
Year: 2012

description: The experiments presented in this investigation were conducted to examine various factors which are known to affect stability in an emulsified system.  In most instances, the results reported were able to provide a better understanding of how these various factors interact with each other in promoting stability in the nonaqueous emulsions of glycerin-olive oil.  From the results presented in can be concluded that in the glycerin-olive oil emulsion system of study of various factors which are known to affect emulsion system can be successfully employed to provide a better understanding of the overall stability process.  Moreover, the results obtained from each individual study may not be completely meaningful, but when combined, much significant information in obtained.  Also, the results suggest that interfacial viscosity and mechanical properties of the interfacial film can be correlated with the stability of an emulsion.
Methoxy and bromo scans on N-(5-methoxyphenyl) methoxybenzenesulphonamides reveal potent cytotoxic compounds, especially against the human breast adenocarcinoma MCF7 cell line
Creators: name: González, Myriam
name: Ovejero-Sánchez, María
name: Vicente-Blázquez, Alba
name: Medarde, Manuel
name: González-Sarmiento, Rogelio
name: Peláez, Rafael
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Hematology

description: Thirty seven N-(5-methoxyphenyl)-4-methoxybenzenesulphonamide with methoxy or/and bromo substitutions (series 1-4) and with different substituents on the sulphonamide nitrogen have been synthesised. 21 showed sub-micromolar cytotoxicity against HeLa and HT-29 human tumour cell lines, and were particularly effective against MCF7. The most potent series has 2,5-dimethoxyanilines, especially the 4-brominated compounds 23–25. The active compounds inhibit microtubular protein polymerisation at micromolar concentrations, thus pointing at tubulin as the target. Co-treatment with the MDR inhibitor verapamil suggests that they are not MDR substrates. Compound 25 showed nanomolar antiproliferative potency. It severely disrupts the microtubule network in cells and arrests cells at the G2/M cell-cycle phase, thus confirming tubulin targeting. 25 triggered apoptotic cell death, and induced autophagy. Docking studies suggest binding in a distinct way to the colchicine site. These compounds are promising new antitumor agents acting on tubulin.
Cyclocephala sexpunctata Laporte 1840
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala sexpunctata

description: Cyclocephala sexpunctata Laporte, 1840
Cyclocephala sex-punctata Laporte 1840: 125 (French Guiana)
Distribution. French Guiana: Laporte 1840: 125; Endrödi 1966a: 306; Brûlé et al. 2011a: 191, 2014: 181; Duranton 2011: 15; Ponchel 2011: 60; Moore et al. 2018b: 246. “Guianas”: Arrow 1937b: 16; Blackwelder 1944: 252. Brazil: Endrödi 1966a: 306; Ratcliffe et al. 2013: 220; Moore et al. 2018b: 246. Venezuela: Endrödi 1966a: 306; Moore et al. 2018b: 246. Other: Endrödi 1966a: 306 (Bolivia, Colombia, Costa Rica, Ecuador, Guatemala, Mexico, Panama, Peru), 1985a: 82, 124 (Bolivia–Mexico); Lachaume 1992: 14 (Bolivia–Mexico); Ratcliffe et al. 2013: 220 (Brazil–Mexico, Bolivia, Colombia, Ecuador, Peru); Moore et al. 2018b: 246 (Bolivia, Colombia, Costa Rica, Ecuador, Guatemala, Honduras, Mexico, Nicaragua, Panama, Peru).
Note. According to Dupuis (2016b: 102), Cyclocephala sexpunctata does not occur in French Guiana, unlike C. aulustjaorum (called C. brevis by Dupuis) which is very similar except for the male genitalia. All records for this species from French Guiana apparently concern specimens of C. aulustjaorum. However, the type locality for C. sexpunctata is French Guiana. This may be due to a mislabeled specimen, but the matter requires additional research.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 181, DOI: 10.5281/zenodo.3678492
Cyclocephala signaticollis Burmeister 1847
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala signaticollis

description: § Cyclocephala signaticollis Burmeister, 1847
Cyclocephala signaticollis Burmeister 1847: 63 (Argentina - LECTOTYPE)
Distribution. French Guiana: Endrödi 1966a: 308; Duranton 2011: 15 (?); Moore et al. 2018b: 247. Brazil: Endrödi 1966a: 308; Moore et al. 2018b: 247. Venezuela: Endrödi 1966a: 308, 1985a: 98, 140; Moore et al. 2018b: 247. Other: Burmeister 1847: 63 (Argentina); Arrow 1937b: 16 (Argentina); Blackwelder 1944: 252 (Argentina); Endrödi 1966a: 308 (Argentina - designation NEOTYPE Cyclocephala signaticollis, Bolivia, Colombia, Mexico, Uruguay, Australia), 1985a: 98, 140 (Venezuela–Argentina, Mexico, Australia); Dechambre 1991: 124 (Argentina - designation LECTOTYPE Cyclocephala signaticollis); Ponchel 2011 (not mentioned); Dupuis 2016b (not mentioned); Moore et al. 2018b: 247 (Argentina, Bolivia, Colombia, Uruguay, Australia).
Note 1. The neotype of Cyclocephala signaticollis designated in Endrödi (1966a: 308) was rendered invalid when type material from Burmeister was recovered and a lectotype was designated in Dechambre (1991: 124).
Note 2. Endrödi (1966a: 308) records Cyclocephala signaticollis for French Guiana, but this record is not repeated in later publications except for Moore et al. (2018b: 247). Duranton (2011: 13) apparently saw no definite specimens from French Guiana, and the species is not mentioned by Ponchel (2011) and Dupuis (2016b). We are unaware of any other records from the research area and have not seen any specimens from the Guianas. We assume this species does not occur in the research area and treat it as such.
Note 3. Endrödi (1966a: 308) records Cyclocephala signaticollis for Mexico, and this record is repeated in Endrödi (1985a: 98, 140). However, according to Ratcliffe et al. (2013: 597) this species only occurs in South America and Australia (where it was introduced), which means that the specimen on which the record was based was either mislabeled or misidentified.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 181, DOI: 10.5281/zenodo.3678492
Von ob Habeck Braunwald 1547
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1877

description: Blick zur Ortstafel mit dem Chamerstock im Hintergrund
description: [Johann Müller Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Molecular and cellular mechanisms of zebrafish fin regeneration
Creators: name: Nechiporuk, Alex
Publisher: name: University of Utah
Year: 2012
Subjects: Cloning
Mid-blastemal

description: According to the National Center for Medical Rehabilitation Research, each year in the United States more than 100,000 individuals lose a limb due to traumatic injury or disease; 7,800 are paralyzed due to spinal cord injury. It is conceivable that these conditions could be treated by activating the body's own genetic instructions to reproduce missing structures or organs. A few vertebrate animals, including urodele amphibians and teleost fish, have an exceptional ability to regenerate various structures, such as limbs, spinal cord, and optic nerve. Limb regeneration in urodeles and fin regeneration in teleosts both appear to include the stages of wound healing and establishment of wound epithelium, recruitment of the blastema, which is defined as a mass of pluripotent mesenchyme cells, and differentiation and outgrowth of the regenerate. Here molecular biological and genetic approaches were applied to study cellular and molecular mechanisms of zebrafish fin regeneration. A classical genetic approach was used to identify four mutants defective in fin regeneration. Histological and molecular analysis shows that these mutants blocked during various stages of fin regeneration. One of these mutations, emmental (emm), prevents formation of a functional blastema through defective cell proliferation and increased apoptosis. Positional cloning revealed that mutation of a zebrafish homologue of yeast sly1 causes the emm phenotype. sly1 is upregulated in blastemal cells during blastema formation and regenerative outgrowth. The data indicate that sly1 is essential for enhanced proliferation that occurs in blastema during regeneration. Another mutant, nightcap (ncp), is specifically blocked during regenerative outgrowth. Positional cloning revealed that ncp
Cyclocephala signatoides Hohne 1923
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala signatoides

description: Cyclocephala signatoides Höhne, 1923
Cyclocephala signatoides Höhne 1923b: 346 (French Guiana - LECTOTYPE)
Distribution. Guyana: Endrödi 1966a: 363 (as Mimeoma signatoides), 1985a: 156 (as Mimeoma signatoides); Moore et al. 2018b: 248. Suriname: MHCN - NEW COUNTRY RECORD (Suriname, Para, Colakreek, (5°27′45″N, 55°13′45″W). 6/ 9-I-2013. A. J. Hielkema. On UV/HPL.). French Guiana: Höhne 1923b: 346; Endrödi 1966a: 363 (designation LECTOTYPE Cyclocephala signatoides), 1985a: 156 (as Mimeoma signatoides); Brûlé et al. 2011a: 192 (as Mimeoma signatoides); Duranton 2011: 17 (as Mimeoma signatoides); Ponchel 2011: 60 (as Mimeoma signatoides); Brûlé and Dalens 2012a annex 4: 18 (as Mimeoma signatoides); Dupuis 2016b: 109 (as Mimeoma signatoides); Moore et al. 2018b: 248. Brazil: Höhne 1923b: 346; Arrow 1937b: 5 (as Mimeoma signatoides); Blackwelder 1944: 250 (as Mimeoma signatoides); Endrödi 1966a: 363 (as Mimeoma signatoides), 1985a: 156 (as Mimeoma signatoides); Moore et al. 2018b: 248. Venezuela: Moore et al. 2018b: 248. Other: Höhne 1923b: 346 (Cuba, Mexico); Arrow 1937b: 5 (Cuba, Mexico - as Mimeoma signatoides); Blackwelder 1944: 250 (Cuba, Mexico - as Mimeoma signatoides); Endrödi 1966a: 363 (Bolivia, Colombia, Cuba, Ecuador, Mexico, Peru - as Mimeoma signatoides), 1985a: 156 (Bolivia, Colombia, Cuba, Ecuador, Mexico, Peru - as Mimeoma signatoides); Moore et al. 2018b: 248 (Bolivia, Colombia, Ecuador, Peru).
Note. Höhne (1923b: 346), Arrow (1937b: 5), Blackwelder (1944: 250) and Endrödi (1966a: 363, 1985a: 156) record Cyclocephala signatoides (named Mimeoma signatoides in the latter four publications) for South America as well as Cuba and Mexico. According to Ratcliffe et al. (2013: 598), the records of C. signatoides (mentioned as M. signatoides) from Mexico are incorrect, as this is a strictly South American species. Ratcliffe and Cave (2015: 291) state the same regarding the records from Cuba.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 182, DOI: 10.5281/zenodo.3678492
Cyclocephala similis Dechambre 1980
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala similis

description: Cyclocephala similis Dechambre, 1980
Cyclocephala similis Dechambre 1980: 47 (French Guiana)
Distribution. French Guiana: Dechambre 1980: 47; Endrödi 1985a: 734; Brûlé et al. 2011a: 191; Duranton 2011: 15; Ponchel 2011: 60; Dupuis 2016b: 109; Moore et al. 2018b: 249.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 182, DOI: 10.5281/zenodo.3678492
Untere Parthie des Weges von der untern zu oberen Baumgartenalp
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1877
Subjects: Wanderweg

description: [Johann Müller Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC