cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Numerical analysis of the light modulation by the frustule of Gomphonema parvulum
title: the role of integrated optical components
titleType: Subtitle
Creators: name: Ghobara, Mohamed Mahmoud Essam
name: Oschatz, Cathleen
name: Fratzl, Peter
name: Reissig, Louisa
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: pennate diatom frustule
subject: micro-optics
subject: near-field optics
subject: photobiology
subject: finite element method
subject: diffraction-driven focusing
subject: photonic jet
subject: Talbot effect
subject: guided-mode resonance
subject: 500 Naturwissenschaften und Mathematik::530 Physik::539 Moderne Physik

description: Siliceous diatom frustules present a huge variety of shapes and nanometric pore patterns. A better understanding of the light modulation by these frustules is required to determine whether or not they might have photobiological roles besides their possible utilization as building blocks in photonic applications. In this study, we propose a novel approach for analyzing the near-field light modulation by small pennate diatom frustules, utilizing the frustule of Gomphonema parvulum as a model. Numerical analysis was carried out for the wave propagation across selected 2D cross-sections in a statistically representative 3D model for the valve based on the finite element frequency domain method. The influences of light wavelength (vacuum wavelengths from 300 to 800 nm) and refractive index changes, as well as structural parameters, on the light modulation were investigated and compared to theoretical predictions when possible. The results showed complex interference patterns resulting from the overlay of different optical phenomena, which can be explained by the presence of a few integrated optical components in the valve. Moreover, studies on the complete frustule in an aqueous medium allow the discussion of its possible photobiological relevance. Furthermore, our results may enable the simple screening of unstudied pennate frustules for photonic applications.
Terahertz Spin Current Dynamics in Antiferromagnetic Hematite
Creators: name: Qiu, Hongsong
name: Seifert, Tom
name: Huang, Lin
name: Zhou, Yongjian
name: Kaspar, Zdenek
name: Zhang, Caihong
name: Wu, Jingbo
name: Fan, Kebin
name: Zhang, Qi
name: Wu, Di
name: Kampfrath, Tobias
name: Song, Cheng
name: Jin, Biaobing
name: Chen, Jian
name: Wu, Peiheng
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: antiferromagnets
subject: spin currents
subject: spin dynamics
subject: terahertz spectroscopy
subject: 500 Naturwissenschaften und Mathematik::530 Physik::539 Moderne Physik

description: An important vision of modern magnetic research is to use antiferromagnets (AFMs) as controllable and active ultrafast components in spintronic devices. Hematite (α-Fe2O3) is a promising model material in this respect because its pronounced Dzyaloshinskii-Moriya interaction leads to the coexistence of antiferromagnetism and weak ferromagnetism. Here, femtosecond laser pulses are used to drive terahertz (THz) spin currents from α-Fe2O3 into an adjacent Pt layer. Two contributions to the generation of the spin current with distinctly different dynamics are found: the impulsive stimulated Raman scatting that relies on the AFM order and the ultrafast spin Seebeck effect that relies on the net magnetization. The total THz spin current dynamics can be manipulated by a medium-strength magnetic field below 1 T. The control of the THz spin current achieved in α-Fe2O3 opens the pathway toward tailoring the exact spin current dynamics from ultrafast AFM spin sources.
Identification of determinants for tRNA substrate recognition by Escherichia coli C/U34 2′-O-methyltransferase
Creators: name: Zhou, Mi
name: Long, Tao
name: Fang, Zhi-Peng
name: Zhou, Xiao-Long
name: Ru-Juan Liu
name: En-Duo Wang
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Molecular Biology
subject: Microbiology
subject: FOS: Biological sciences
subject: Biochemistry
subject: Biophysics

description: Post-transcriptional modifications bring chemical diversity to tRNAs, especially at positions 34 and 37 of the anticodon stem-loop (ASL). TrmL is the prokaryotic methyltransferase that catalyzes the transfer of the methyl group from S-adenosyl-L-methionine to the wobble base of tRNALeuCAA and tRNALeuUAA isoacceptors. This Cm34/Um34 modification affects codon-anticodon interactions and is essential for translational fidelity. TrmL-catalyzed 2′-O-methylation requires its homodimerization; however, understanding of the tRNA recognition mechanism by TrmL remains elusive. In the current study, by measuring tRNA methylation by TrmL and performing kinetic analysis of tRNA mutants, we found that TrmL exhibits a fine-tuned tRNA substrate recognition mechanism. Anticodon stem-loop minihelices with an extension of 2 base pairs are the minimal substrate for EcTrmL methylation. A35 is a key residue for TrmL recognition, while A36-A37-A38 are important either via direct interaction with TrmL or due to the necessity for prior isopentenylation (i6) at A37. In addition, TrmL only methylates pyrimidines but not purine residues at the wobble position, and the 2′-O-methylation relies on prior N6-isopentenyladenosine modification at position 37.
Analysis of the Indiana Magazine of History Web Publishing Platforms and Workflows
Creators: name: Eichmann-Kalwara, Nickoal
name: Dalmau, Michelle
name: Homenda, Nicholas
Publisher: name: figshare
Year: 2015
Subjects: subject: Library and Information Studies
subject: FOS: Media and communications

description: This report outlines an exploration of migrating a history journal to Open Journal Systems and potential sustainable publishing workflows. August 2013.
Gd3+–Trityl–Nitroxide Triple Labeling and Distance Measurements in the Heterooligomeric Cobalamin Transport Complex in the Native Lipid Bilayers
Creators: name: Ketter, Sophie
name: Joseph, Benesh
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: Pulsed electron–electron double resonance spectroscopy
subject: PELDOR
subject: DEER
subject: Gd3+–trityl–nitroxide
subject: 500 Naturwissenschaften und Mathematik::530 Physik::539 Moderne Physik

description: Increased efforts are being made for observing proteins in their native environments. Pulsed electron–electron double resonance spectroscopy (PELDOR, also known as DEER) is a powerful tool for this purpose. Conventionally, PELDOR employs an identical spin pair, which limits the output to a single distance for monomeric samples. Here, we show that the Gd3+–trityl–nitroxide (NO) three-spin system is a versatile tool to study heterooligomeric membrane protein complexes, even within their native membrane. This allowed for an independent determination of four different distances (Gd3+–trityl, Gd3+–NO, trityl–NO, and Gd3+–Gd3+) within the same sample. We demonstrate the feasibility of this approach by observing sequential ligand binding and the dynamics of complex formation in the cobalamin transport system involving four components (cobalamin, BtuB, TonB, and BtuF). Our results reveal that TonB binding alone is sufficient to release cobalamin from BtuB in the native asymmetric bilayers. This approach provides a potential tool for the structural and quantitative analysis of dynamic protein–protein interactions in oligomeric complexes, even within their native surroundings.
Foreward to Meaningful Metrics: A 21st Century Librarian's Guide to Bibliometrics, Altmetrics, and Research Impact
Creators: name: Impactstory Team
name: Piwowar, Heather
name: Priem, Jason
Publisher: name: figshare
Year: 2015
Subjects: subject: Library and Information Studies
subject: FOS: Media and communications

description: Originally published as foreward to Meaningful metrics : a 21st century librarian's guide to bibliometrics, altmetrics, and research impact, edited by Robin Chin Roemer & Rachel Borchardt. http://www.amazon.com/Meaningful-Metrics-Librarians-Bibliometrics-Altmetrics/dp/0838987559
Light-oxygen-voltage (LOV)-sensing domains: activation mechanism and optogenetic stimulation
Creators: name: Flores-Ibarra, Andrea
name: Maia, Raiza N. A.
name: Olasz, Bence
name: Church, Jonathan R.
name: Gotthard, Guillaume
name: Schapiro, Igor
name: Heberle, Joachim
name: Nogly, Przemyslaw
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: photoreceptor
subject: LOV
subject: optogenetics
subject: signal transduction
subject: molecular mechanism
subject: 500 Naturwissenschaften und Mathematik::530 Physik::539 Moderne Physik

description: The light-oxygen-voltage (LOV) domains of phototropins emerged as essential constituents of light-sensitive proteins, helping initiate blue light-triggered responses. Moreover, these domains have been identified across all kingdoms of life. LOV domains utilize flavin nucleotides as co-factors and undergo structural rearrangements upon exposure to blue light, which activates an effector domain that executes the final output of the photoreaction. LOV domains are versatile photoreceptors that play critical roles in cellular signaling and environmental adaptation; additionally, they can noninvasively sense and control intracellular processes with high spatiotemporal precision, making them ideal candidates for use in optogenetics, where a light signal is linked to a cellular process through a photoreceptor. The ongoing development of LOV-based optogenetic tools, driven by advances in structural biology, spectroscopy, computational methods, and synthetic biology, has the potential to revolutionize the study of biological systems and enable the development of novel therapeutic strategies.
Fiber-tip spintronic terahertz emitters
Creators: name: Paries, Felix
name: Tiercelin, Nicolas
name: Lezier, Geoffrey
name: Vanwolleghem, Mathias
name: Selz, Felix
name: Syskaki, Maria-Andromachi
name: Kammerbauer, Fabian
name: Jakob, Gerhard
name: Jourdan, Martin
name: Kläui, Mathias
name: Kaspar, Zdenek
name: Kampfrath, Tobias
name: Seifert, Tom S.
name: Freymann, Georg Von
name: Molter, Daniel
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: spintronic terahertz sytems
subject: fiber-tip spintronic terahertz emitter
subject: single-mode fiber waveguiding
subject: 500 Naturwissenschaften und Mathematik::530 Physik::539 Moderne Physik

description: Spintronic terahertz emitters promise terahertz sources with an unmatched broad frequency bandwidth that are easy to fabricate and operate, and therefore easy to scale at low cost. However, current experiments and proofs of concept rely on free-space ultrafast pump lasers and rather complex benchtop setups. This contrasts with the requirements of widespread industrial applications, where robust, compact, and safe designs are needed. To meet these requirements, we present a novel fiber-tip spintronic terahertz emitter solution that allows spintronic terahertz systems to be fully fiber-coupled. Using single-mode fiber waveguiding, the newly developed solution naturally leads to a simple and straightforward terahertz near-field imaging system with a 90%-10% knife-edge-response spatial resolution of 30 µm.
A review of intelligence GWAS hits: their relationship to country IQ and the issue of spatial autocorrelation.
Creators: name: Piffer, Davide
Publisher: name: figshare
Year: 2015
Subjects: subject: Anthropology
subject: FOS: Sociology
subject: Personality, Social and Criminal Psychology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience and Physiological Psychology
subject: Evolutionary Biology

description: Evidence for an association between IQ and common genetic variants at the population levels is presented along with methods to detect selection on polygenic traits
Seven-coordinated cobalt(II) complexes with 2,6-diacetylpyridine bis(4-hydroxybenzoylhydrazone): synthesis, characterisation, DNA binding and cleavage properties
Creators: name: Gup, Ramazan
name: Gökçe, Cansu
name: Dilek, Nefise
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Chemistry
subject: Biotechnology
subject: Molecular Biology
subject: Cell Biology
subject: Microbiology
subject: FOS: Biological sciences
subject: Medicine
subject: Biochemistry
subject: Biophysics

description: Synthesis and characterisation of three seven-coordinated cobalt(II) complexes of 2,6-diacetylpyridine bis(4-hydroxybenzoylhydrazone) (H4L) ligand, [Co(H2L)(H2O)2] (1), [Co(H4L)(N3)2] (2) and [Co(H4L)(NCS)2] (3) are described. The structures of the complexes were characterised by elemental analysis, IR, UV–vis and magnetic susceptibility measurement. The molecular structure of the [Co(H4L)(NCS)2] (3) was also determined by X-ray crystallography. Single crystal X-ray revealed that the Co(II) complex (3) has a pentagonal–bipyramidal coordination geometry, with pentadentate N3O2 ligand in the equatorial plane of the bipyramid and two isothiocyanato groups in the axial area. Interaction of the cobalt(II) complexes with CT-DNA was investigated by absorption titration method and viscosity measurements. Cleavage activity of the complexes with pBR 322 plasmid DNA was evaluated by agarose gel electrophoresis in presence and absence of an oxidative agent, and the mechanism of DNA cleavage was investigated. The results suggest that the cobalt(II) complexes bind effectively and they exhibit nuclease activity, which has strong dependence on the concentration of complex and reaction time, both in presence and absence of hydrogen peroxide.
title: The effect of reintroductions on the genetic variability in Eurasian lynx populations
title: the cases of Bohemian–Bavarian and Vosges–Palatinian populations
titleType: Subtitle
Creators: name: Bull, James K.
name: Heurich, Marco
name: Saveljev, Alexander P.
name: Schmidt, Krzysztof
name: Fickel, Jörns
name: Förster, Daniel W.
Publisher: name: Universität Potsdam
Year: 2020

description: Over the past ~40 years, several attempts were made to reintroduce Eurasian lynx to suitable habitat within their former distribution range in Western Europe. In general, limited numbers of individuals have been released to establish new populations. To evaluate the effects of reintroductions on the genetic status of lynx populations we used 12 microsatellite loci to study lynx populations in the Bohemian–Bavarian and Vosges–Palatinian forests. Compared with autochthonous lynx populations, these two reintroduced populations displayed reduced genetic diversity, particularly the Vosges–Palatinian population. Our genetic data provide further evidence to support the status of ‘endangered’ and ‘critically endangered’ for the Bohemian–Bavarian and Vosges–Palatinian populations, respectively. Regarding conservation management, we highlight the need to limit poaching, and advocate additional translocations to bolster genetic variability.
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe, 884
Identification of determinants for tRNA substrate recognition by Escherichia coli C/U34 2′-O-methyltransferase
Creators: name: Zhou, Mi
name: Long, Tao
name: Fang, Zhi-Peng
name: Zhou, Xiao-Long
name: Ru-Juan Liu
name: En-Duo Wang
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Molecular Biology
subject: Microbiology
subject: FOS: Biological sciences
subject: Biochemistry
subject: Biophysics

description: ABSTRACTPost-transcriptional modifications bring chemical diversity to tRNAs, especially at positions 34 and 37 of the anticodon stem-loop (ASL). TrmL is the prokaryotic methyltransferase that catalyzes the transfer of the methyl group from S-adenosyl-L-methionine to the wobble base of tRNALeuCAA and tRNALeuUAA isoacceptors. This Cm34/Um34 modification affects codon-anticodon interactions and is essential for translational fidelity. TrmL-catalyzed 2′-O-methylation requires its homodimerization; however, understanding of the tRNA recognition mechanism by TrmL remains elusive. In the current study, by measuring tRNA methylation by TrmL and performing kinetic analysis of tRNA mutants, we found that TrmL exhibits a fine-tuned tRNA substrate recognition mechanism. Anticodon stem-loop minihelices with an extension of two base pairs are the minimal substrate for EcTrmL methylation. A35 is a key residue for TrmL recognition, while A36-A37-A38 are important either via direct interaction with TrmL or due to the necessity for prior isopentenylation (i6) at A37. In addition, TrmL only methylates pyrimidines but not purine residues at the wobble position, and the 2′-O-methylation relies on prior N6-isopentenyladenosine modification at position 37.
title: HSP60 reduction protects against diet-induced obesity by modulating energy metabolism in adipose tissue
Creators: name: Hauffe, Robert
name: Rath, Michaela
name: Schell, Mareike
name: Ritter, Katrin
name: Kappert, Kai
name: Deubel, Stefanie
name: Ott, Christiane
name: Jähnert, Markus
name: Jonas, Wenke
name: Schürmann, Annette
name: Kleinridders, André
Publisher: name: Universitätsverlag Potsdam
Year: 2022

description: Objective Insulin regulates mitochondrial function, thereby propagating an efficient metabolism. Conversely, diabetes and insulin resistance are linked to mitochondrial dysfunction with a decreased expression of the mitochondrial chaperone HSP60. The aim of this investigation was to determine the effect of a reduced HSP60 expression on the development of obesity and insulin resistance. Methods Control and heterozygous whole-body HSP60 knockout (Hsp60+/−) mice were fed a high-fat diet (HFD, 60% calories from fat) for 16 weeks and subjected to extensive metabolic phenotyping. To understand the effect of HSP60 on white adipose tissue, microarray analysis of gonadal WAT was performed, ex vivo experiments were performed, and a lentiviral knockdown of HSP60 in 3T3-L1 cells was conducted to gain detailed insights into the effect of reduced HSP60 levels on adipocyte homeostasis. Results Male Hsp60+/− mice exhibited lower body weight with lower fat mass. These mice exhibited improved insulin sensitivity compared to control, as assessed by Matsuda Index and HOMA-IR. Accordingly, insulin levels were significantly reduced in Hsp60+/− mice in a glucose tolerance test. However, Hsp60+/− mice exhibited an altered adipose tissue metabolism with elevated insulin-independent glucose uptake, adipocyte hyperplasia in the presence of mitochondrial dysfunction, altered autophagy, and local insulin resistance. Conclusions We discovered that the reduction of HSP60 in mice predominantly affects adipose tissue homeostasis, leading to beneficial alterations in body weight, body composition, and adipocyte morphology, albeit exhibiting local insulin resistance.
description: Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe; 1235
title: Ordnung des Instituts für Katholische Theologie der Fakultät für Kulturwissenschaften der Universität Paderborn
title: vom 14. April 2020
titleType: Subtitle
Creators: name: Universität Paderborn
Publisher: name: UB-PAD - Paderborn University Library
Year: 2020

description: Amtliche Mitteilungen / Universität Paderborn
title: Bekanntmachung der Aufwandsentschädigung des Hochschulrats der Universität Paderborn für den Zeitraum vom 01.04.2019 bis zum 31.03.2020
title: vom 14. April 2020
titleType: Subtitle
Creators: name: Universität Paderborn
Publisher: name: UB-PAD - Paderborn University Library
Year: 2020

description: Amtliche Mitteilungen / Universität Paderborn
Lavandin (Lavandula × intermedia Emeric ex Loiseleur) essential oil from Spain: determination of aromatic profile by gas chromatography–mass spectrometry, antioxidant and lipoxygenase inhibitory bioactivities
Creators: name: Carrasco, Alejandro
name: Martinez-Gutierrez, Ramiro
name: Tomas, Virginia
name: Tudela, Jose
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences

description: Lavandin (Lavandula × intermedia Emeric ex Loiseleur) essential oils (EOs), from Abrial, Super and Grosso cultivars, cultivated and extracted in the South East of Spain, were analysed by using GC/MS to determine their composition, in both relative (peak area) and absolute (using standard curves) concentrations. Linalool (34–47%), linalyl acetate (17–34%), camphor (4–9%) and eucalyptol (3–7%) were determined as the main molecules. This characterisation was completed with the enantioselective gas chromatography, where ( − )-linalool, (+)-camphor and ( − )-linalyl acetate were determined as the main components. Antioxidant activity was evaluated positively by several methods: activity against free radicals, chelating and reducing power, probably due to linalool and linalyl acetate. Mild inhibitory activity on lipoxygenase was observed supporting potential anti-inflammatory activity, mainly due to linalool and camphor. These properties support the potential use of L. × intermedia essential oils as natural cosmetic and natural pharmaceutical ingredient to fight several skin diseases.
Evaluating a Fit-For-Purpose Integrated Service-Oriented land and climate change information system for mountain community adaptation
Creators: name: Khezri, Adish
name: Bennett, Rohan
name: Zevenbergen, Jaap
Publisher: name: Swinburne
Year: 2024

description: Climate change challenges mountain communities to prepare themselves via Community-Based Adaptation (CBA) plans that reduce vulnerability. This paper outlines the evaluation of a developed web-based information system to support CBA, referred to as a Mountain Community Adaptive System (MCAS). The web-based user interface visualizes collated data from data providers, integrating it with near real-time climate and weather datasets. The interface provides more up-to-date information than was previously available on the environment, particularly on land and climate. MCAS, a cloud-based Land Information System (LIS), was developed using an Agile-inspired approach offering system creation based on bare minimum system requirements and iterative development. The system was tested against Fit-For-Purpose Land Administration (FFP LA) criteria to assess the effectiveness in a case from Nepal. The results illustrate that an MCAS-style system can provide useful information such as land use status, adaptation options, near real-time rainfall and temperature details, amongst others, to enable services that can enhance CBA activities. The information can facilitate improved CBA planning and implementation at the mountain community level. Despite the mentioned benefits of MCAS, ensuring system access was identified as a key limitation: smartphones and mobile technologies still remain prohibitively expensive for members of mountain communities, and underlying information communication technology (ICT) infrastructures remain under-developed in the assessed mountain communities. The results of the evaluation further suggest that the land-related aspects of climate change should be added to CBA initiatives. Similarly, existing LIS could have functionalities extended to include climate-related variables that impact on land use, tenure, and development.
Hierarchical Nearest-Neighbor Gaussian Process Models for Large Geostatistical Datasets
Creators: name: Abhirup Datta
name: Sudipto Banerjee
name: Finley, Andrew O.
name: Gelfand, Alan E.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Spatial process models for analyzing geostatistical data entail computations that become prohibitive as the number of spatial locations become large. This article develops a class of highly scalable nearest-neighbor Gaussian process (NNGP) models to provide fully model-based inference for large geostatistical datasets. We establish that the NNGP is a well-defined spatial process providing legitimate finite-dimensional Gaussian densities with sparse precision matrices. We embed the NNGP as a sparsity-inducing prior within a rich hierarchical modeling framework and outline how computationally efficient Markov chain Monte Carlo (MCMC) algorithms can be executed without storing or decomposing large matrices. The floating point operations (flops) per iteration of this algorithm is linear in the number of spatial locations, thereby rendering substantial scalability. We illustrate the computational and inferential benefits of the NNGP over competing methods using simulation studies and also analyze forest biomass from a massive U.S. Forest Inventory dataset at a scale that precludes alternative dimension-reducing methods. Supplementary materials for this article are available online.
Smoothed Lexis Diagrams With Applications to Lung and Breast Cancer Trends in Taiwan
Creators: name: Li-Chu Chien
name: Yuh-Jenn Wu
name: Hsiung, Chao A.
name: Lu-Hai Wang
name: I-Shou Chang
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Science Policy
subject: Cancer
subject: Mathematics
subject: FOS: Mathematics
subject: Biotechnology
subject: Medicine

description: Cancer surveillance research often begins with a rate matrix, also called a Lexis diagram, of cancer incidence derived from cancer registry and census data. Lexis diagrams with 3- or 5-year intervals for age group and for calendar year of diagnosis are often considered. This simple smoothing approach suffers from a significant limitation; important details useful in studying time trends may be lost in the averaging process involved in generating a summary rate. This article constructs a smoothed Lexis diagram and indicates its use in cancer surveillance research. Specifically, we use a Poisson model to describe the relationship between the number of new cases, the number of people at risk, and a smoothly varying incidence rate for the study of the incidence rate function. Based on the Poisson model, we use the standard Lexis diagram to introduce priors through the coefficients of Bernstein polynomials and propose a Bayesian approach to construct a smoothed Lexis diagram for the study of the effects of age, period, and cohort on incidence rates in terms of straightforward graphical displays. These include the age-specific rates by year of birth, age-specific rates by year of diagnosis, year-specific rates by age of diagnosis, and cohort-specific rates by age of diagnosis. We illustrate our approach by studying the trends in lung and breast cancer incidence in Taiwan. We find that for nearly every age group the incidence rates for lung adenocarcinoma and female invasive breast cancer increased rapidly in the past two decades and those for male lung squamous cell carcinoma started to decrease, which is consistent with the decline in the male smoking rate that began in 1985. Since the analyses indicate strong age, period, and cohort effects, it seems that both lung cancer and breast cancer will become more important public health problems in Taiwan. Supplementary materials for this article are available online.
Metal complexes with N-(trifluoromethylbenzyl)iminodiacetate chelators (x-3F ligands). Part I. Copper(II) chelates of p-3F, m-3F, and o-3F with or without imidazole-like ligands
Creators: name: Serrano-Braceras, Marina
name: Choquesillo-Lazarte, Duane
name: Domínguez-Martín, Alicia
name: Vílchez-Rodríguez, Ester
name: García-Rubiño, María Eugenia
name: González-Pérez, Josefa María
name: Castiñeiras, Alfonso
name: Niclós-Gutiérrez, Juan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Earth and Environmental Sciences
Cell Biology
Physics
Biochemistry
Biophysics

description: Eight Cu(II) complexes with N-(p-, m- or o-trifluoromethylbenzyl)iminodiacetate chelators (x-3F ligands) have been synthesized to promote C–F/H interligand interactions involving the F3C-group: {[Cu(μ2-p-3F)(H2O)]·3H2O]}n (1), [Cu(m-3F)(H2O)2] (2), [Cu(p-3F)(Him)(H2O)] (3), [Cu(m-3F)(Him)(H2O)] (4), [Cu(o-3F)(Him)(H2O)] (5), [Cu2(p-3F)2(H5Meim)2(H2O)2] (6), [Cu(m-3F)(H5Meim)(H2O)] (7), and [Cu(o-3F)(H5Meim)(H2O)] (8) [Him and H5Meim = imidazole and the “remote” tautomer 5-methylimidazole, respectively]. The compounds were studied by single-crystal X-ray diffraction, FT-IR, electronic spectra and coupled thermogravimetric + FT-IR methods. The conformation of the iminodiacetate chelating moiety (IDA group) is fac-NO + O(apical) in 1 and mer-NO2 in 2–8. The fac-IDA conformation observed in 1 is related to its polymeric structure and the coordination of a O’-carboxylate donor, from an adjacent complex unit, trans to the Cu–N(IDA) bond. The mer-IDA conformation in 2 is in agreement with similar compounds with an aqua ligand trans to the corresponding Cu–N(IDA) bond. As expected, the ternary complexes 3–8 feature a mer-IDA conformation. Some of the studied complexes exhibit disorder in the –CF3 group and C–H⋯F interligand interactions along with conventional N–H⋯O and O–H⋯O interactions. The thermal decomposition of all studied compounds under air flow produces variable amounts of trifluorotoluene.
Smoothed Lexis Diagrams with Applications to Lung and Breast Cancer Trends in Taiwan
Creators: name: Li-Chu Chien
name: Yuh-Jenn Wu
name: Hsiung, Chao A.
name: Lu-Hai Wang
name: I-Shou Chang
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Science Policy
subject: Cancer
subject: Mathematics
subject: FOS: Mathematics
subject: Biotechnology
subject: Medicine

description: Cancer surveillance research often begins with a rate matrix, also called a Lexis diagram, of cancer incidence derived from cancer registry and census data. Lexis diagrams with 3- or 5-year intervals for age group and for calendar year of diagnosis are often considered. This simple smoothing approach suffers from a significant limitation; important details useful in studying time trends may be lost in the averaging process involved in generating a summary rate. This paper constructs a smoothed Lexis diagram and indicates its use in cancer surveillance research. Specifically, we utilize a Poisson model to describe the relationship between the number of new cases, the number of people at risk, and a smoothly varying incidence rate for the study of the incidence rate function. Based on the Poisson model, we use the standard Lexis diagram to introduce priors through the coefficients of Bernstein polynomials and propose a Bayesian approach to construct a smoothed Lexis diagram for the study of the effects of age, period, and cohort on incidence rates in terms of straight-forward graphical displays. These include the age-specific rates by year of birth, age-specific rates by year of diagnosis, year-specific rates by age of diagnosis, and cohort-specific rates by age of diagnosis. We illustrate our approach by studying the trends in lung and breast cancer incidence in Taiwan. We find that for nearly every age group the incidence rates for lung adenocarcinoma and female invasive breast cancer increased rapidly in the past two decades and those for male lung squamous cell carcinoma started to decrease, which is consistent with the decline in the male smoking rate that began in 1985. Since the analyses indicate strong age, period, and cohort effects, it seems that both lung cancer and breast cancer will become more important public health problems in Taiwan.
Metal complexes with N-(trifluoromethylbenzyl)iminodiacetate chelators (x-3F ligands). Part I. Copper(II) chelates of p-3F, m-3F and o-3F with or without imidazole-like ligands
Creators: name: Serrano-Braceras, Marina
name: Choquesillo-Lazarte, Duane
name: Domínguez-Martín, Alicia
name: Vílchez-Rodríguez, Ester
name: García-Rubiño, María Eugenia
name: González-Pérez, Josefa María
name: Castiñeiras, Alfonso
name: Niclós-Gutiérrez, Juan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Earth and Environmental Sciences
Cell Biology
Physics
Biochemistry
Biophysics

description: Eight Cu(II) complexes with N-(p-, m- or o-trifluoromethylbenzyl)iminodiacetate chelators (x-3F ligands) have been synthesized to promote C-F/H interligand interactions involving the F3C-group: {[Cu(μ2-p-3F)(H2O)]·3H2O]}n (1), [Cu(m-3F)(H2O)2] (2), [Cu(p-3F)(Him)(H2O)] (3), [Cu(m-3F)(Him)(H2O)] (4), [Cu(o-3F)(Him)(H2O)] (5), [Cu2(p-3F)2(H5Meim)2(H2O)2] (6), [Cu(m-3F)(H5Meim)(H2O)] (7) and [Cu(o-3F)(H5Meim)(H2O)] (8) [Him and H5Meim = imidazole and the “remote” tautomer 5-methylimidazole, respectively]. The compounds were studied by single crystal X-ray diffraction, FT-IR, electronic spectra and coupled thermogravimetric + FT-IR methods. The conformation of the iminodiacetate chelating moiety (IDA) is fac-NO+O(apical) in 1 and mer-NO2 in 2-8. The fac-IDA conformation observed in 1 is related to its polymeric structure and the coordination of a O’-carboxylate donor, from an adjacent complex unit, trans to the Cu-N(IDA) bond. The mer-IDA conformation in 2 is in agreement with similar compounds with an aqua ligand trans to the corresponding Cu-N(IDA) bond. As expected, the ternary complexes 3-8 feature a mer-IDA conformation. Some of the studied complexes exhibit disorder in the –CF3 group and C-H···F inter-ligand interactions along with conventional N-H···O and O-H···O interactions. The thermal decomposition of all studied compounds under air flow produces variable amounts of trifluorotoluene.
Investigation of the dynamics of the viral immediate-early protein 1 in different conformations and oligomerization states
Creators: name: Stump, Joachim D.
name: Sticht, Heinrich
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Inorganic Chemistry
subject: 60506 Virology
subject: Computational Biology

description: The viral immediate-early protein 1 (IE1) is crucial for efficient replication of cytomegalovirus (CMV). A recent crystal structure of the IE1 protein from rhesus CMV revealed that the protein exhibits a novel fold and crystallizes in two slightly different dimeric arrangements. Molecular dynamics simulations and energetic analyses performed in this study show that both dimers are stable and allowed us to identify a common set of five residues that appear particularly important for dimer formation. These residues are distributed over the entire dimer interface and do not form a typical hot spot for protein interactions. In addition, the dimer interface of IE1 proved to include a high portion of hydrophilic interactions pointing toward the transient nature of dimer formation. Characterization of monomeric and dimeric IE1 revealed three sequentially discontinuous dynamic domains that exhibit correlated motion within the domain and are simultaneously anti-correlated to the adjacent domains. The hinge motions observed between the dynamic domains increase the shape complementarity to the coiled–coil region of tripartite motif proteins, suggesting that the detected dynamics of IE1 might be physiologically important by enabling a better interaction with its cellular target molecules.
Investigation of the dynamics of the viral immediate-early protein 1 in different conformations and oligomerization states
Creators: name: Stump, Joachim D.
name: Sticht, Heinrich
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Biological Sciences
subject: Chemistry
subject: Molecular Biology
subject: Cell Biology
subject: Physics
subject: Biochemistry
subject: Biophysics

description: The viral immediate-early protein 1 (IE1) is crucial for efficient replication of cytomegalovirus (CMV). A recent crystal structure of the IE1 protein from rhesus CMV revealed that the protein exhibits a novel fold and crystallizes in two slightly different dimeric arrangements. Molecular dynamics simulations and energetic analyses performed in the present study show that both dimers are stable and allowed us to identify a common set of five residues that appear particularly important for dimer formation. These residues are distributed over the entire dimer interface and do not form a typical hot spot for protein interactions. In addition, the dimer interface of IE1 proved to include a high portion of hydrophilic interactions pointing towards the transient nature of dimer formation. Characterization of monomeric and dimeric IE1 revealed three sequentially discontinuous dynamic domains that exhibit correlated motion within the domain and are simultaneously anti-correlated to the adjacent domains. The hinge motions observed between the dynamic domains increase the shape complementarity to the coiled-coiled region of tripartite motif (TRIM) proteins, suggesting that the detected dynamics of IE1 might be physiologically important by enabling a better interaction with its cellular target molecules.
Predicting substrate selectivity between UGT1A9 and UGT1A10 using molecular modelling and molecular dynamics approach
Creators: name: Tripathi, Satya Prakash
name: Rameshwar Prajapati
name: Verma, Neha
name: Sangamwar, Abhay T.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Chemistry
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Microbiology
subject: Biochemistry
subject: Biophysics

description: Uridine 5′-diphospho-glucuronosyltransferase-1A9 (UGT1A9) expressed in the liver, shows good sequence identity with UGT1A10, expressed in the intestine. Both uridine 5′-diphospho-glucuronosyltransferase (UGT) isoforms show comprehensive overlapping substrate selectivity but there are differences in stereoselectivity, regiospecificity and rate of glucuronidation of the substrates. Multiple sequence alignment analyses of UGT1A9 and UGT1A10 showed that 13% of the residues in N-terminal domain (NTD) are non-identical between them. Herein, authors attempted homology modelling of UGT1A9 and UGT1A10 and validation using software tools and reported mutagenic studies. A molecular docking study of the known substrates is performed on UGT1A9 and UGT1A10 homology models. The non-identical N-terminal residues ranging from 111 to 117 in UGT1A9 and UGT1A10 were identified to play a central role in the substrate selectivity. However, substrate binding is performed by Ser111, Gly115 and Leu117 in UGT1A10 and Gly111, Asp115 and Phe117 in UGT1A9. This study reports new residues in NTD, showing interaction with uridine 5′-diphospho-glucuronic acid which binds with C-terminal domain. Further, molecular dynamics simulations were carried out to study the role of non-identical residues in substrate identification. The study demonstrates the folding of the UGT enzyme, particularly, helix-loop-helix transition and movement of Nα3-2 helix, in response to substrate and co-substrate binding.
Modelos de evolución del Covid-19 en Panamá
Creators: name: Laguardia, José
name: Ledezma, Agapito
Publisher: name: Zenodo
Year: 2020
Subjects: Covid 19
Panamá
SIR
Redes neuronales

description: En este informe hacemos una predicción a medio plazo del comportamiento del Covid-19 tomando en consideración las medidas tomadas por el gobierno de Panamá usando un modelo epimediológico, dependiente del tiempo así como un pronostico a corto plazo usando un enfoque basado en Redes Neuronas Artificiales, Arboles y Reglas de Regresión.
ВЗАИМОДЕЙСТВИЕ ДЕКСТРАНА С АМИНОКИСЛОТАМИ
Creators: name: Эшпулатов, И.И.
name: Чинибекова, Н.К.
Publisher: name: Zenodo
Year: 2024

description: α-Аминокислоты и их производные в связи с широким спектром их действия вызывают большой интерес. Они входят в состав многих лекарственных препаратов, предназначенных для лечения самых разнообразных заболеваний. Известно, что N-замещенные α-аминокислоты не вызывают нежелательных побочных эффектов и предназначены для больных, которым противопоказано использование традиционных средств. Следует отметить, что в настоящее время полисахариды широко исследуются как биополимерные носители лекарственных препаратов. Этот интерес к полисахаридам можно объяснить их биосовместимостью, хорошей стабильностью, не токсичностью, гидрофильностью и биодеградируемостью. Особенно представляет интерес модификация полисахаридов аминокислотами, которая позволяет создавать препараты пролонгированного действия с низкой токсичностью [1]. Поэтому исследования модификации полисахаридов аминокислотами актуальна на сегодняшний день, так как описанные в литературе методы синтеза полисахарид-аминокислотных производных несовершенны и требуют дополнительных исследований.
Towards Collaborative Reproducibility: Pinning Repository of Binary Distributions
Creators: name: Phong, Nguyễn Gia
name: Huy, Ngô Ngọc Đức
Publisher: name: Zenodo
Year: 2021
Subjects: packaging
peer-to-peer network
content addressing

description: Instead of pinning individual requirements or packaging up the entire environment in a container, how about archiving a repository snapshot of all dependencies? This talk at PyData Global 2021 will explore the characteristics of this approach, as well as what have been done with the InterPlanetary Wheels to realize them. IPWHL is a fresh take on Python dependency management. It aims to be a downstream wheel supplier (in a similar fashion to GNU/Linux distributions), whilst taking advantage of a content-addressing peer-to-peer network to provide a reproducible, easy-to-mirror source of packages. While communicating the ideas around IPWHL, I will also discuss and compare it with common packaging and archival practices, highlighting the gap between upstream developers and the users of their libraries, in the following order: Upstream and downstream development: why do we need both? PyPI is a package index, not a user-facing repository! Containers are not as useful as you (might) think. Is IPWHL one-size-fits-all? No, but… How to use IPWHL and how can one help? After the presentation, an attendee shall know the advantages (and shortcomings) of IPWHL and how to get started. Prior knowledge on Python packaging and IPFS can be helpful, but not required to understand the content of the talk.
Effective Factors for Increasing University Publication and Citation Rate
Creators: name: Ebrahim, Nader Ale
Publisher: name: figshare
Year: 2015
Subjects: Education

description: Despite the vital role of paper publication and citation in higher education institutions (HEIs), literature on publication exercises is relatively scarce. There are a number of factors which influence the rate of university publications and citations. Accordingly, with a focus on policy perspectives, this paper discusses publication exercises by addressing the factors that can increase or decrease the rate of publication and citation in HEIs. The investigated zones are divided into two macro and micro levels, in which macro level deals with global policy and micro level is related to local and university policies. The effective factors and their relevant criteria are traced in all the aforementioned policies.
MPEC 2024-K103 : 2024 KL
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 KL

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Impact of rice-straw biochar on some selected soil properties and rice (Oryza sativa L.) grain yield
Creators: name: Iqbal, Zahid
Publisher: name: figshare
Year: 2015
Subjects: subject: Environmental Science
subject: 99901 Agricultural Engineering
subject: FOS: Other engineering and technologies
subject: Soil Science
subject: Genetics
subject: FOS: Biological sciences
subject: Education

description: Biochar is a co-product of pyrolysis of rice straw biomass, its qualities vary according to pyrolysis conditions but
it mainly contains phosphorus and potassium. The carbon (C) content in biochar is stable, so it can be applied to
soils which enlarging the C sink. In the present investigation, a biochar was produced from rice straw residue,
characterized and its effect on rice grain yield, pH, soil organic carbon, total N and changes in NH4+–N and
NO3-–N concentrations in rice soil under intermittent wetting-drying and continuous flooding were examined.
The results showed that, the rice straw-derived biochair produced was neutral in pH and the cation exchange
capacity 37 cmol kg -1. Application of biochar, reduces the NH4+–N and NO3-–N concentrations in soil
irrespective of moisture conditions. Such effect was more pronounced on NH4+–N and NO3-–N concentrations
under flooding condition and intermittent wetting&drying condition, respectively. Increasing the rate of rice
straw derived biochair application rate had significantly decreased both the NH4+–N and NO3-–N
concentrations in soil. The resulted rice yield from T3 (30 g biochair per kg-1 dry soil) was the highest and
significant difference compared to other treatments. The biochair application significantly enhanced the total soil
N, soil organic carbon and soil pH under both flooding and wetting&drying conditions.
Appendix 3 to "The Status of Biological Invasions and their Management in South Africa in 2022 [FIRST DRAFT FOR PUBLIC COMMENT]"—Metadata for the species list
Creators: name: SANBI
name: CIB
Publisher: name: Zenodo
Year: 2022

description: For more details see: http://iasreport.sanbi.org.za
 SANBI and CIB 2020. Appendix 3 to "The Status of Biological Invasions and their Management in South Africa in 2022 [FIRST DRAFT FOR PUBLIC COMMENT]"—Metadata for the species list. South African National Biodiversity Institute, Kirstenbosch and DSI-NRF Centre of Excellence for Invasion Biology, Stellenbosch. http://dx.doi.org/10.5281/zenodo.7433113
Appendix 3 to "The Status of Biological Invasions and their Management in South Africa in 2022 [SECOND DRAFT FOR PUBLIC COMMENT]"—Metadata for the species list
Creators: name: SANBI
name: CIB
Publisher: name: Zenodo
Year: 2023

description: For more details see: http://iasreport.sanbi.org.za
 SANBI and CIB 2023. Appendix 3 to "The Status of Biological Invasions and their Management in South Africa in 2022 [SECOND DRAFT FOR PUBLIC COMMENT]"—Metadata for the species list. South African National Biodiversity Institute, Kirstenbosch and DSI-NRF Centre of Excellence for Invasion Biology, Stellenbosch. http://dx.doi.org/10.5281/zenodo.8047672