cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Angular momentum redistribution by mixed modes in evolved low-mass stars. I. Theoretical formalism
Creators: name: Belkacem, K.
name: Marques, J. P.
name: Goupil, M. J.
name: Sonoi, T.
name: Ouazzani, R. M.
name: Dupret, M. A.
name: Mathis, S.
name: Mosser, B.
name: Grosjean, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Seismic observations by the space-borne mission \emph{Kepler} have shown that the core of red giant stars slows down while evolving, requiring an efficient physical mechanism to extract angular momentum from the inner layers. Current stellar evolution codes fail to reproduce the observed rotation rates by several orders of magnitude, and predict a drastic spin-up of red giant cores instead. New efficient mechanisms of angular momentum transport are thus required. In this framework, our aim is to investigate the possibility that mixed modes extract angular momentum from the inner radiative regions of evolved low-mass stars. To this end, we consider the Transformed Eulerian Mean (TEM) formalism, introduced by Andrews \& McIntyre (1978), that allows us to consider the combined effect of both the wave momentum flux in the mean angular momentum equation and the wave heat flux in the mean entropy equation as well as their interplay with the meridional circulation. In radiative layers of evolved low-mass stars, the quasi-adiabatic approximation, the limit of slow rotation, and the asymptotic regime can be applied for mixed modes and enable us to establish a prescription for the wave fluxes in the mean equations. The formalism is finally applied to a $1.3 M_\odot$ benchmark model, representative of observed CoRoT and \emph{Kepler} oscillating evolved stars. We show that the influence of the wave heat flux on the mean angular momentum is not negligible and that the overall effect of mixed modes is to extract angular momentum from the innermost region of the star. A quantitative and accurate estimate requires realistic values of mode amplitudes. This is provided in a companion paper.
description: Accepted in A&A, 11 pages, and 6 figures
Biodiversity and distribution of cephalopods caught by trawling along the Northern and Central Adriatic Sea
Creators: name: KRSTULOVIĆ ŠIFNER, Svjetlana
name: PEHARDA, Melita
name: VRGOČ, Nedo
name: ISAJLOVIĆ, Igor
name: DADIĆ, Vlado
name: PETRIĆ, Mirela
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2011

description: The teuthofauna assemblages of the Northern and Central Adriatic Sea were identified using a time series (1996- 2004) of bottom trawl surveys performed in the scope of the MEDITS project. During 8 trawl surveys a total of 32 cephalopod species was caught, belonging to 8 families. All species are known in the Adriatic Sea but some species as Neorossia caroli and Octopus defilippi were recorded for the first time in the area of investigation. The density index of cephalopods was greatest from 100 to 200 m and biomass index at depths between 10 and 50 m. Based on the density index data, the most important species were: Eledone moschata (10-50 m), Alloteuthis media, Sepia elegans and E. moschata (50- 100 m), A. media and Illex coindetii (100-200 m), I. coindetii and Eledone cirrhosa (200-500 m). The results of multi - variate analysis, based on Bray-Curtis similarity indices, showed significant differences between cephalopod assemblages in defined depth strata, with 10-50 m and 50-100 m strata being the most similar. In addition, based on the values of biomass and their commercial importance, five cephalopod species were chosen and their spatial distribution and recent trends were described.
(400881) Margery Mudie
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Extended experimental and analytical results from Plastic multicellular development of Myxococcus xanthus: genotype–environment interactions in a physical gradient
Creators: name: Rivera-Yoshida, Natsuko
name: Arzola, Alejandro V.
name: Angel, Juan A. Arias Del
name: Franci, Alessio
name: Travisano, Michael
name: Escalante, Ana E.
name: Benítez, Mariana
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Biophysics
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Developmental Biology

description: Additional results include the reaction norms for all the measured phenotypic traits, FAMD multivariate analysis results, linear regression for reaction norms.
Chechen Chernie Vodvi : the most lethal human "Black Widows"
Creators: name: Winkeler, Lucia M.
name: 0000-0001-6411-0952
Publisher: name: The University of Texas at Austin
Year: 2021
Subjects: Chechnya
Russia
Suicide terrorism
Women terrorists
Chechen Black Widows
Shahidas

description: Terrorism originating in the North Caucasus region has been one of the Russian government’s most significant security concerns for at least the past twenty years. Chechen women who join terrorist groups pose a significant and unique threat to the Russian Federation. These women are the so-called "Black Widows" or shahidki and their lethality should not be underestimated. This report seeks to unpack the possible motivating factors that drive a Chechen woman to become a "Black Widow". I explain the three most commonly proposed scholarly explanations for why women, in this case Chechen women, turn to terrorist acts, and then analyze which reasons are the most plausible in the present-day. After establishing the necessary context regarding Russian-Chechen relations—from Imperial Russia to present-day—and an overview of the concepts of terrorism and radical jihadist ideology—this report delves into an analysis of the factors that can pull a Chechen woman to turn to terrorism. Next, I provide quantitative data to illustrate how women suicide bombers in Chechnya, and abroad, are a significant and deadly concern. Finally, I offer my concluding thoughts and suggestions for future research
Tables S1 - S7 from Invasion-mediated effects on marine trophic interactions in a changing climate: positive feedbacks favour kelp persistence.
Creators: name: Miranda, Ricardo J.
name: Coleman, Melinda A.
name: Tagliafico, Alejandro
name: Rangel, Maria S.
name: Mamo, Lea T.
name: Barros, Francisco
name: Kelaher, Brendan P.
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: The interactive effects of ocean warming and invasive species are complex and remain a source of uncertainty for projecting future ecological change. Climate-mediated change to trophic interactions can have pervasive ecological consequences, but the role of invasion in mediating trophic effects is largely unstudied. Using manipulative experiments in replicated outdoor mesocosms, we reveal how near-future ocean warming and macrophyte invasion scenarios interactively impact gastropod grazing intensity and preference for consumption of foundation macroalgae (Ecklonia radiata and Sargassum vestitum). Elevated water temperature increased the consumption of both macroalgae through greater grazing intensity. Given the documented decline of kelp (E. radiata) growth at higher water temperatures, enhanced grazing could contribute to the shift from kelp-dominated to Sargasssum-dominated reefs that is occurring at the low-latitude margins of kelp distribution. However, the presence of a native invader (Caulerpa filiformis) was related to low consumption by the herbivores on dominant kelp at warmer temperatures. Thus, antagonistic effects between climate change and a range expanding species can favour kelp persistence in a warmer future. Introduction of species should, therefore, not automatically be considered unfavourable under climate change scenarios. Climatic changes are increasing the need for effective management actions to address the interactive effects of multiple stressors and their ecological consequences, rather than single threats in isolation.
Theory and practice in environmental design: post normal sciences and visioning process oriented design for sustainability
Creators: name: Fanzini, Daniele
name: Rotaru, Irina
name: Bergamini, Isabella
Publisher: name: TECHNE - Journal of Technology for Architecture and Environment
Year: 2017

description: This contribution contains an analysis of the relationship between theory and practice in architecture, started from the particular similarity between scientific and design research and intended to nurture the debate around the possible evolution of the disciplinary tools of Architectural Technology. The contents are organized as follows: In the first section, there are investigated the affinities that supported the constitution of the methodological and instrumental apparatus of the technological culture of design. The second part is introducing the relationship between technological culture of design and post-normal sciences as a possible answer to the particular conditions of complexity and uncertainty of the moment. The third section is emphasizing the analogy between the instrumentations of several research areas that operate between environmental sustainability, futures studies and technological and environmental design as a starting point for further operational insights.
description: TECHNE - Journal of Technology for Architecture and Environment, TECHNE 13 (2017): Theories Practice Design
Implementing Survivorship Care Plans for Colon Cancer Survivors
Creators: name: Gerstel, Adrian
name: Hawkins, Nikki A.
name: Mayer, Deborah K.
name: Sadiq, Teresa E.
name: Triglianos, Tammy
name: Walton, Ann Marie Lee
name: Davies, Janine M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: To evaluate the feasibility, usability, and satisfaction of a survivorship care plan (SCP) and identify the optimum time for its delivery during the first 12 months after diagnosis.
ФАРМАКОГНОСТИЧЕСКОЕ ИЗУЧЕНИЕ ВИДОВ РОДА ACHILLEA L.
Creators: name: Камалова, Зулайхо
Publisher: name: Zenodo
Year: 2023

description: Методом хромато-масс-спектрометрии установлено, что в эфирном масле тысячелистника пойменного преобладают сесквитерпеноиды: хамазулен (23,23%), кариофилленоксид (15,83%), β-кариофиллен (6,03%). В эфирном масле тысячелистника обыкновенного в наибольших количествах идентифицированы монотерпеноиды: β-пинен (25,35%), сабинен (13,63%).
Asymptotics of Jack characters
Creators: name: Śniady, Piotr
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: Primary 05E05, Secondary 20C30, 05C10, 05C30

description: Jack characters are a one-parameter deformation of the characters of the symmetric groups; a deformation given by the coefficients in the expansion of Jack symmetric functions in the basis of power-sum symmetric functions. We study Jack characters from the viewpoint of the asymptotic representation theory. In particular, we give explicit formulas for their asymptotically top-degree part, in terms of bicolored oriented maps with an arbitrary face structure. We also study their multiplicative structure and their structure constants and we prove that they fulfill approximate factorization property, a convenient tool for proving Gaussianity of fluctuations of random Young diagrams.
description: 52 pages. Version 3: change of title. This version was created by merging two papers (and removing a lot of the discussion): arXiv:1603.04268 and version 2 of the current paper
«Ars sine scientia nihil est»
Creators: name: Chizzoniti, DOMENICO
Publisher: name: TECHNE - Journal of Technology for Architecture and Environment
Year: 2017

description: Even though a tradition of work is devoted to the definition «Ars sine scientia nihil est» (the art without science is nothing- S.T., 1, 14, 8 c: Scientica autem artificis est causa artificiatorum; eo quod artifex operatur per suum intellectum) words of the Parisian architect Jean Mignot pronounced during the construction of the Milan Cathedral in 1398, a question may arise: What is the rhetorical admissible rate of construction that does not invalidate the role of architecture or that empties it of meaning? This essay is divided into four points that are paradigmatic of the relationship between technical expression, building expertise, and figurative invention. With this choice some intuitions about a specific building tradition are tested by comparison with the design established practices and some experimentation, particularly significant with respect to the relationship between emancipation and constructive figuration instance.
description: TECHNE - Journal of Technology for Architecture and Environment, TECHNE 13 (2017): Theories Practice Design
Marine triclads (Platyhelminthes, Tricladida, Maricola), a preliminary molecular approach to their phylogeny
Creators: name: CHARBAGI-BARBIROU, Kmar
name: ÁLVAREZ-PRESAS, Marta
name: VILA, Miquel
name: GAMMOUDI, Mehrez
name: TEKAYA, Saïda
name: RIUTORT, Marta
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2011

description: Marine triclads are a relatively rare group of animals that, although found worldwide, have received little attention. However some of its species present some characteristics that can make them good models for developmental studies, namely this group presents the only gonochoristic species within the Tricladida. As for their taxonomy and phylo- genetic relationships, the number of families and subfamilies, and the situation of the species within them has been quite controversial. Only one classification is based on a cladistic phylogenetic analysis, and there are even doubts on the presence of a synapomorphy for the whole group. Given this situation we decided to test the molecular data as a source of information to infer their phylogenetic relationships. We have obtained some new 18S and 28S sequences from diverse maricolan flatworms and added to the ones present in the databases. Despite some uncertainties, the ribosomal data demonstrates to be a good phylogenetic marker to unravel the relationships within the marine planarians. These data represent a complement to the insufficient morphological characters.
Evolution of technology, innovation of languages
Creators: name: Barucco, MariaAntonia
Publisher: name: TECHNE - Journal of Technology for Architecture and Environment
Year: 2017

description: The development of technological research can be studied on the publications of the SAIE (in particular in the publications known as “Cuore Mostra”) and on the network of connections generated by these books. These sources constitute a tool for building the social capital that we identify with the Architectural Technology. A selection of text citations is inevitable: this means betraying the breadth and the overall sense of SAIE publications. On the other hand, each reading, re-reading and translation enriches the texts of meanings and creates connections that can share (with the originals) aspirations, language and discipline of the work, which are based on the intent to cross the border between the technical and theoretical aspects of the research work and the design.
description: TECHNE - Journal of Technology for Architecture and Environment, TECHNE 13 (2017): Theories Practice Design
Histological investigation of the reproductive cycle of the limpet Patella caerulea Linnaeus, 1758
Creators: name: BELKHODJA, Hela
name: JAAFOURA, Mohamed Habib
name: MISSAOUI, Hechmi
name: ROMDHANE, Mohamed Salah
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2011

description: This study devised a staging system for and monitored the gonad development of the limpet Patella caerulea in La Goulette harbour (Gulf of Tunis) using a Gonad Somatic Index (GSI) and histological techniques. Sex ratio varied along the study period, where samples always presenting more males than females. Maturation began in August/September for both sexes. In males, spawning took place from March to August 2006 and from April to June 2007. Regarding females, spawning took place from May to July 2006 and from April to July 2007. A secondary spawning peak was observed in January 2007 for both sexes. No statistical differences were registered between GSI of both sexes; however, the use of the GSI in determining the annual reproductive cycle is discussed. High wind speed under optimum conditions of temperature and salinity appear to induce spawning in the limpets.
Substansi Artikel Standar Sinta
Creators: name: Mulyaningsih, Indrya
Publisher: name: Zenodo
Year: 2023
Subjects: artikel jurnal
akreditasi jurnal
publikasi ilmiah
Sinta

description: Materi disampaikan pada Kegiatan Penyusunan Konsep Jurnal: Pengelola Jurnal di Lingkungan Badan Pengembangan dan Pembinaan Bahasa Kementerian Pendidikan, Kebudayaan, Riset, dan Teknologi, Selasa 7 Februari 2023.
Tables S1 - S7 from Invasion-mediated effects on marine trophic interactions in a changing climate: positive feedbacks favour kelp persistence
Creators: name: Miranda, Ricardo J.
name: Coleman, Melinda A.
name: Tagliafico, Alejandro
name: Rangel, Maria S.
name: Mamo, Lea T.
name: Barros, Francisco
name: Kelaher, Brendan P.
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: The interactive effects of ocean warming and invasive species are complex and remain a source of uncertainty for projecting future ecological change. Climate-mediated change to trophic interactions can have pervasive ecological consequences, but the role of invasion in mediating trophic effects is largely unstudied. Using manipulative experiments in replicated outdoor mesocosms, we reveal how near-future ocean warming and macrophyte invasion scenarios interactively impact gastropod grazing intensity and preference for consumption of foundation macroalgae (Ecklonia radiata and Sargassum vestitum). Elevated water temperature increased the consumption of both macroalgae through greater grazing intensity. Given the documented decline of kelp (E. radiata) growth at higher water temperatures, enhanced grazing could contribute to the shift from kelp-dominated to Sargasssum-dominated reefs that is occurring at the low-latitude margins of kelp distribution. However, the presence of a native invader (Caulerpa filiformis) was related to low consumption by the herbivores on dominant kelp at warmer temperatures. Thus, antagonistic effects between climate change and a range expanding species can favour kelp persistence in a warmer future. Introduction of species should, therefore, not automatically be considered unfavourable under climate change scenarios. Climatic changes are increasing the need for effective management actions to address the interactive effects of multiple stressors and their ecological consequences, rather than single threats in isolation.
Improving Couples’ Quality of Life Through  a Web-Based Prostate Cancer Education Intervention
Creators: name: Chang, Hao
name: Kinneer, Patty
name: Dunn, Mary W.
name: Rini, Christine
name: Johnson, David C.
name: Song, Lixin
name: Nielsen, Matthew E.
name: Deal, Allison M.
name: Palmer, Mary H.
name: Mark, Barbara
name: Teal, Randall
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: To evaluate the feasibility and acceptability of a newly developed web-based, couple-oriented intervention called Prostate Cancer Education and Resources for Couples (PERC).
Innovative energy and environmental standards for architecture
Creators: name: D'Olimpio, Domenico
Publisher: name: TECHNE - Journal of Technology for Architecture and Environment
Year: 2017

description: The article, in order to identify new "energy models" according to which to conceive the future transformation and construction of the environment, starts from the description of current energy and environmental models, beginning with those defined by Reyner Banham on End of the 1960s (conservative, selective, regenerative, bioclimatic model) to identify the characteristics of a new energy model consistent with the current energy-environmental efficiency instances of buildings.
description: TECHNE - Journal of Technology for Architecture and Environment, TECHNE 13 (2017): Theories Practice Design
(400880) William MacDougal Ogilvie
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
“There’s a certain Slant of light…”. The tools of qualitative forecasting and interpretative synthesis of environmental factors in the field of sustainable architectural and urban design
Creators: name: Bovati, Marco
Publisher: name: TECHNE - Journal of Technology for Architecture and Environment
Year: 2017

description: Experiences in energy upgrading for Modern heritage demonstrate that the simple reapplication of general practice risks losing an overall conception of the built work, including in cases where the original project drew on resource-optimisation criteria similar to the current requirements for environmental sustainability. The present study examines this context, drawing on two programs of applied research: the first concerning materials and Modern architectural design under Italian “autarchy”; the second concerning more general problems of sustainable rehabilitation for 20th century heritage properties. The two programs share a research methodology in which the knowledge-building stage extends to interpretation of the construction, in terms of the “technological culture” of the original architectural planning.
description: TECHNE - Journal of Technology for Architecture and Environment, TECHNE 13 (2017): Theories Practice Design
Synchronization of Goodwin's oscillators under boundedness and nonnegativeness constraints for solutions
Creators: name: Proskurnikov, Anton V.
name: Cao, Ming
Publisher: name: arXiv
Year: 2015
Subjects: subject: Systems and Control (eess.SY)
subject: Optimization and Control (math.OC)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: In the recent paper by Hamadeh et al. (2012) an elegant analytic criterion for incremental output feedback passivity (iOFP) of cyclic feedback systems (CFS) has been reported, assuming that the constituent subsystems are incrementally output strictly passive (iOSP). This criterion was used to prove that a network of identical CFS can be synchronized under sufficiently strong linear diffusive coupling. A very important class of CFS consists of biological oscillators, named after Brian Goodwin and describing self-regulated chains of enzymatic reactions, where the product of each reaction catalyzes the next reaction, while the last product inhibits the first reaction in the chain. Goodwin's oscillators are used, in particular, to model the dynamics of genetic circadian pacemakers, hormonal cycles and some metabolic pathways. In this paper we point out that for Goodwin's oscillators, where the individual reactions have nonlinear (e.g. Mikhaelis-Menten) kinetics, the synchronization criterion, obtained by Hamadeh et al., cannot be directly applied. This criterion relies on the implicit assumption of the solution boundedness, dictated also by the chemical feasibility (the state variables stand for the concentrations of chemicals). Furthermore, to test the synchronization condition one needs to know an explicit bound for a solution, which generally cannot be guaranteed under linear coupling. At the same time, we show that these restrictions can be avoided for a nonlinear synchronization protocol, where the control inputs are "saturated" by a special nonlinear function (belonging to a wide class), which guarantees nonnegativity of the solutions and allows to get explicit ultimate bounds for them. We prove that oscillators synchronize under such a protocol, provided that the couplings are sufficiently strong.
description: under review in IEEE Transactions on Automatic Control
Involvement in Decision Making and Satisfaction With Treatment Among Partners of Patients With Newly Diagnosed Localized Prostate Cancer
Creators: name: Greene, Giselle
name: Song, Lixin
name: Weaver, Mark
name: Symes, Yael
name: Heineman, Rachael G.
name: Chen, Ronald C.
name: Tatum, Kimberly
name: Barbosa, Brittney D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: To examine partner involvement in treatment decision making for localized prostate cancer, congruence between partner involvement and patient preference, reasons for partner noninvolvement, and partner satisfaction with patient treatment.
Patient-Reported Symptoms and Quality of Life  in Adults With Acute Leukemia: A Systematic Review
Creators: name: Walton, Ann Marie L.
name: Shaw-Kokot, Julia
name: Reeve, Bryce B.
name: Bryant, Ashley Leak
name: Mayer, Deborah K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Systematically summarize findings from research conducted on adult acute leukemia survivors as they relate to symptoms and quality of life (QOL).
Fachkräftesituation in Einrichtungen der Offenen Kinder- und Jugendarbeit in Schleswig-Holstein
Creators: name: Voigts, Gunda
name: Przybylski, Katharina
Publisher: name: HAW Hamburg
Year: 2025
Subjects: subject: 360: Soziale Probleme, Sozialarbeit

description: Spezifische Länderauswertung Schleswig-Holstein der bundesweiten Online-Befragung zur „Fachkräftesituation in Einrichtungen der Offenen Kinder- und Jugendarbeit“.
Supplementary information from Long-term trends in wild-capture and population dynamics point to an uncertain future for captive elephants.
Creators: name: Jackson, John
name: Childs, Dylan Z.
name: Khyne U. Mar
name: Htut, Win
name: Lummaa, Virpi
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Maintaining sustainable populations in captivity without supplementation through wild-capture is a major challenge in conservation that zoos and aquaria are working towards. However, the capture of wild animals continues for many purposes where conservation is not the primary focus. Wild-capture hinders long-term conservation goals by reducing remaining wild populations, but the direct and long-term indirect consequences of wild-capture for captive population viability are rarely addressed using longitudinal data. We explored the implications of changes in wild-capture on population dynamics in captivity over 54 years using a multi-generational studbook of working Asian elephants (Elephas maximus) from Myanmar, the largest remaining captive elephant population. Here we show that population growth and birth rates declined between 1960 and 2014 with declines in wild-capture. Importantly, wild-caught females had reduced birth rates and a higher mortality risk. However, despite the disadvantages of wild-capture, the population may not be sustainable without it, with immediate declines owing to an unstable age-structure that may last for 50 years. Our results highlight the need to assess the long-term demographic consequences of wild-capture to ensure the sustainability of captive and wild populations as species are increasingly managed and conserved in altered or novel environments.
Polymorphisms in CYP1B1, GSTM1, GSTT1 and GSTP1, and susceptibility to breast cancer
Creators: name: Freimanis, Rita I.
name: Shaw, Cindy S.
name: Van Emburgh, Beth O.
name: Sawyer, Lynda R.
name: Hu, Jennifer J.
name: Allen, Glenn O.
name: Perrier, Nancy D.
name: Carey, Lisa A.
name: Sherrill, Gary B.
name: Mosley, Libyadda J.
name: Rubin, Peter
name: Miller, Mark Steven
name: Levine, Edward A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Polymorphisms in the cytochrome P450 1B1 (CYP1B1) and glutathione S-transferase (GST) drug metabolic enzymes, which are responsible for metabolic activation/detoxification of estrogen and environmental carcinogens, were analyzed for their association with breast cancer risk in 541 cases and 635 controls from a North Carolina population. Each polymorphism, altering the catalytic function of their respective enzymes, was analyzed in Caucasian and African-American women. As reported in previous studies, individual polymorphisms did not significantly impact breast cancer risk in either Caucasian or African-American women. However, African-American women exhibited a trend towards a protective effect when they had at least one CYP1B1 119S allele (OR=0.53; 95% CI=0.20–1.40) and increased risk for those women harboring at least one CYP1B1 432V allele (OR=5.52; 95% CI=0.50–61.37). Stratified analyses demonstrated significant interactions in younger (age ≤60) Caucasian women with the CYP1B1 119SS genotype (OR=3.09; 95% CI=1.22–7.84) and younger African-American women with the GSTT1 null genotype (OR=4.07; 95% CI=1.12–14.80). A notable trend was also found in Caucasian women with a history of smoking and at least one valine allele at GSTP1 114 (OR=2.12; 95% CI=1.02–4.41). In Caucasian women, the combined GSTP1 105IV/VV and CYP1B1 119AA genotypes resulted in a near 2-fold increase in risk (OR=1.96; 95% CI=1.04–3.72) and the three way combination of GSTP1 105IV/VV, CYP1B1 119AS/SS and GSTT1 null genotypes resulted in an almost 4-fold increase in risk (OR=3.97; 95% CI=1.27–12.40). These results suggest the importance of estrogen/carcinogen metabolic enzymes in the etiology of breast cancer, especially in women before the age of 60, as well as preventative measures such as smoking cessation.
Industrial culture and contemporary project design: examples of experimental building construction systems
Creators: name: Paoletti, Ingrid
Publisher: name: TECHNE - Journal of Technology for Architecture and Environment
Year: 2017

description: This paper intend to deepen, within the broad theme of technological culture, theory and practice of architectural project, at which industrial culture does and will refer the architectural project in the near future, emphasizing the potential that contemporary techniques are slowly but pervasively offering to the construction industry.
description: TECHNE - Journal of Technology for Architecture and Environment, TECHNE 13 (2017): Theories Practice Design
The NQO1*2/*2 polymorphism is associated with poor overall survival in patients following resection of stages II and IIIa non-small cell lung cancer
Creators: name: Keller, Steven M.
name: Johnson, David H.
name: Kolesar, Jill M.
name: Marsh, Sharon
name: Dahlberg, Suzanne E.
name: McLeod, Howard L.
name: Schiller, Joan H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: NAD(P)H:quinone oxidoreductase 1 (NQO1), is a cytosolic flavoenzyme that catalyzes the two-electron reduction of quinones into hydroquinones. A polymorphism (NQO1*2) alters enzymatic activity of NQO1 resulting in diminished NQO1 activity. Malignancies with NQO1*2 may be resistant to radiation and chemotherapy with resulting poorer survival. NQO1 allele was evaluated in subjects enrolled in ECOG 3590, a randomized comparison of radiation (RT) vs radiation and chemotherapy with cisplatin/etoposide (RCT) in patients with completely resected stages II and IIIa NSCLC. Overall survival was estimated using the Kaplan-Meier method and compared via the log-rank test. Cox models were used to assess the impact of covariates on outcomes. Among 152 patients with assessable samples, 24 (16%) had NQO1*2. Median follow-up was 139 months. The presence of NQO1*2/*2 was associated with decreased overall survival (OS) (median in the heterozygote/wild-type group 42.3 vs. 33.5 months in the variant group, p=0.04). In a multivariable Cox model, variant NQO1 (HR=1.58, p=0.05), age <60 (HR=0.67, p=0.04), PS 1 (HR=1.47, p=0.05), cardiovascular disease (HR=1.93, p=0.003) and alkaline phosphatase <100 mg/ml (HR=0.59, p=0.005) were all significant predictors of OS. NQO1*2/*2 may be an independent predictor of poor overall survival in individuals with resected stages II and IIIa NSCLC. Although the basis for the NQO1 association with decreased survival requires additional evaluation, NQO1 may represent a biomarker for guiding individualized therapy.
New mouse xenograft model modulated by tumor-associated fibroblasts for human multi-drug resistance in cancer
Creators: name: Liu, Feng
name: Zhao, Qiang
name: Fallon, John K.
name: Liu, Dan
name: Ma, Yan
name: Lin, Zhiqiang
name: Wang, Yongjun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: We developed an MDR tumor model that is modulated by tumor-associated fibroblasts. Studies on proliferation of tumor cell lines including paclitaxel-sensitive and resistant cell lines were performed. The expressions of P-gp and α-smooth muscle actin (α-SMA) antigen were evaluated by immunohistochemistry and western blot analysis. Quantitative P-gp analyses of different cell lines were accomplished by nanoUPLC-MS/MS. Tumor cell colony formation assay and established xenograft model was used to investigate the relationship between P-gp expression, fibroblast levels and tumorigenesis. The mouse xenograft model was developed after co-inoculation with MDR tumor cells and NIH/3T3 fibroblast cells. There was no correlation between tumorigenesis in vivo and the growth rate of cells in vitro. The proliferation among different cell lines had no significant differences, but the P-gp expression and tumor growth in the xenograft model were fairly different. P-gp determination and α-SMA immunofluorescence staining clarified the relationship between P-gp expression, fibroblast levels and tumorigenesis. It was more difficult for tumor cells with higher P-gp levels to recruit fibroblasts in vivo, resulting in lower tumorigenesis due to the lack of structural and chemical support during tumor progression. In the established paclitaxel-resistant mouse xenograft model, no obvious antitumor effect was observed after Taxol treatment, but a significant decrease in tumor size for the group treated with gemcitabine sensitive to the model. The results show that the added fibroblasts do not disturb the applicability of the model in MDR. Therefore, this mouse xenograft MDR model could serve as an effective tool for MDR research.
(400879) George Watson Neish
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The RP-Mdm2-p53 Pathway and Tumorigenesis
Creators: name: de Marval, Paula L.Miliani
name: Zhang, Yanping
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The dynamic processes of cell growth and division are under constant surveillance. As one of the primary “gatekeepers” of the cell, the p53 tumor suppressor plays a major role in sensing and responding to a variety of stressors to maintain cellular homeostasis. Recent studies have shown that inhibition of ribosomal biogenesis can activate p53 through ribosomal protein (RP)-mediated suppression of Mdm2 E3 ligase activity. Mutations in Mdm2 that disrupt RP binding have been detected in human cancers; however, the physiological significance of the RP-Mdm2 interaction is not completely understood. We generated mice carrying a single cysteine-to-phenylalanine substitution in the central zinc finger of Mdm2 (Mdm2C305F) that disrupts Mdm2’s binding to RPL11 and RPL5. Despite being developmentally normal and maintaining an intact p53 response to DNA damage, the Mdm2C305F mice demonstrate a diminished p53 response to perturbations in ribosomal biogenesis, providing the first in vivo evidence for an RP-Mdm2-p53 signaling pathway. Here we review some recent studies about RP-Mdm2-p53 signaling and speculate on the relevance of this pathway to human cancer.
Regulation of p53: a collaboration between Mdm2 and Mdmx
Creators: name: Pei, Dongsheng
name: Zhang, Yanping
name: Zheng, Junnian
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: p53 plays an important role in the regulation of the cell cycle, DNA repair, and apoptosis and is an attractive cancer therapeutic target. Mdm2 and Mdmx are recognized as the main p53 negative regulators. Although it is still unknown why Mdm2 and Mdmx both are required for p53 degradation, a model has been proposed whereby these two proteins function independent of one another; Mdm2 acts as an E3 ubiquitin ligase that catalyzes the ubiquitination of p53 for degradation, whereas Mdmx inhibits p53 by binding to and masking the transcriptional activation domain of p53, without causing its degradation. However, Mdm2 and Mdmx have been shown to function collaboratively. In fact, recent studies have pointed to a more important role for an Mdm2/Mdmx co-regulatory mechanism for p53 regulation than previously thought. In this review, we summarize current progress in the field about the functional and physical interactions between Mdm2 and Mdmx, their individual and collaborative roles in controlling p53, and inhibitors that target Mdm2 and Mdmx as a novel class of anticancer therapeutics.
Supplementary information from Long-term trends in wild-capture and population dynamics point to an uncertain future for captive elephants
Creators: name: Jackson, John
name: Childs, Dylan Z.
name: Khyne U. Mar
name: Htut, Win
name: Lummaa, Virpi
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Maintaining sustainable populations in captivity without supplementation through wild-capture is a major challenge in conservation that zoos and aquaria are working towards. However, the capture of wild animals continues for many purposes where conservation is not the primary focus. Wild-capture hinders long-term conservation goals by reducing remaining wild populations. Furthermore, the direct and long-term indirect consequences of wild-capture for captive population viability are rarely addressed using longitudinal data. We explored the implications of changes in wild-capture on population dynamics in captivity over 54 years using a multi-generational studbook of working Asian elephants (Elephas maximus) in Myanmar, the largest remaining captive elephant population. Here we show that population growth and birth rates declined between 1960 and 2014 with declines in wild-capture. Importantly, wild-caught females had reduced birth rates and higher mortality risk. However, despite the disadvantages of wild-capture, the population may not be sustainable without it, with immediate declines due to an unstable age-structure that may last for 50 years. Our results highlight the need to assess the long-term demographic consequences of wild-capture to ensure the sustainability of captive populations as species are increasingly managed and conserved in altered or novel environments.
(400878) Margaret Ann Watson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Ras inhibition boosts galectin-7 at the expense of galectin-1 to sensitize cells to apoptosis
Creators: name: Kloog, Yoel
name: Barkan, Batya
name: Cox, Adrienne D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Galectins are a family of β-galactoside-binding lectins that exert diverse extracellular and intracellular effects. Galectin-7 and galectin-1 show opposing effects on proliferation and survival in different cell types. Galectin-7 is a p53-induced gene and an enhancer of apoptosis, whereas galectin-1 induces tumorigenicity and resistance to apoptosis in several types of cancers. We show here that in cells derived from neurofibromin-deficient (Nf1−/−) malignant peripheral nerve sheath tumors (MPNSTs), Ras inhibition by S-trans,trans-farnesylthiosalicylic-acid (FTS; Salirasib) shifts the pattern of galectin expression. Whereas FTS decreased levels of both active Ras and galectin-1 expression, it dramatically increased both the mRNA and protein expression levels of galectin-7. Galectin-7 accumulation was mediated through JNK inhibition presumably resulting from the observed induction of p53, and was negatively regulated by the AP-1 inhibitor JDP2. Expression of galectin-7 by itself decreased Ras activation in ST88-14 cells and rendered them sensitive to apoptosis. This observed shift in galectin expression pattern together with the accompanying shift from cell proliferation to apoptosis represents a novel pattern of Ras inhibition by FTS. This seems likely to be an important phenomenon in view of the fact that both enhanced cell proliferation and defects of apoptosis constitute major hallmarks of human cancers and play a central role in the resistance of MPNSTs to anti-cancer treatments. These findings suggest that FTS, alone or in combination with chemotherapy agents, may be worth developing as a possible treatment for MPNSTs.
Efficient Numerical Evaluation of Feynman Integral
Creators: name: Li, Zhao
name: Wang, Jian
name: Yan, Qi-Shu
name: Zhao, Xiaoran
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Feynman loop integrals are a key ingredient for the calculation of higher order radiation effects, and are responsible for reliable and accurate theoretical prediction. We improve the efficiency of numerical integration in sector decomposition by implementing a quasi-Monte Carlo method associated with the CUDA/GPU technique. For demonstration we present the results of several Feynman integrals up to two loops in both Euclidean and physical kinematic regions in comparison with those obtained from FIESTA3. It is shown that both planar and non-planar two-loop master integrals in the physical kinematic region can be evaluated in less than half a minute with $\mathcal{O}(10^{-3})$ accuracy, which makes the direct numerical approach viable for precise investigation of higher order effects in multi-loop processes, e.g. the next-to-leading order QCD effect in Higgs pair production via gluon fusion with a finite top quark mass.
description: 8 pages, 5 figures, published in Chinese Physics C
(400877) William Neish
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Supplemental material from Sleep restriction caused impaired emotional regulation without detectable brain activation changes—a functional magnetic resonance imaging study.
Creators: name: Tamm, Sandra
name: Nilsonne, Gustav
name: Schwarz, Johanna
name: Armita Golkar
name: Kecklund, Göran
name: Petrovic, Predrag
name: Fischer, Håkan
name: Åkerstedt, Torbjörn
name: Lekander, Mats
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Neuroscience
subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology
subject: 60801 Animal Behaviour
subject: FOS: Biological sciences

description: Figures and tables reporting results for the older group
(400876) Elizabeth Wallace
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(400875) Jean M[arion] Neave
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.