cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Therapeutic but Not Therapy: Using Critical Spirituality to Engage with Traumatic Experiences
Creators: name: Gardner, Fiona
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 5005
subject: Theology
classificationCode: 5004
subject: Religious studies

description: Participants in critical reflection workshops and peer supervision often comment that the process feels therapeutic, enabling them to engage with challenging experiences, even although it is clearly not therapy. This reflective article explores these comments, particularly how the processes of critical reflection embedded in critical spirituality can foster a deep exploration of traumatic experiences that undermine the sense of self and the ability to act with agency. While spirituality is broadly defined as that which gives life meaning including a sense of the transcendent, the ‘critical’ aspect includes the influence of the person’s own and the broader social context. Using two participant examples for illustration, key aspects of the process are identified: unearthing and naming deeply held, limiting and often longstanding assumptions influencing the person’s sense of who they are and how they operate. Next, understanding the prevailing social context can generate liberating new perspectives. Asking what is meaningful and why given the person’s spirituality can foster new, freeing and enabling assumptions, values and beliefs and experimenting with new ways of being and acting. What often emerges is that participants come to recognise the depth of meaning that transforms their perception of their experience and sense of themselves.
Identifying priority aquatic refuges to sustain freshwater biodiversity in intermittent streams in eastern Australia
Creators: name: Yu, S
name: Rose, PM
name: Bond, Nick
name: Bunn, SE
name: Kennard, MJ
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 41
subject: Environmental sciences

description: The hydrological variability of intermittent streams means that the spatial distribution of dry-season aquatic refuges within river networks and the temporal dynamics of hydrological connectivity between them are critical for the persistence of aquatic biodiversity. Here, a new approach is demonstrated to identify surface water bodies as priority refuges for efficient conservation management of freshwater biodiversity in intermittent stream networks. Recently developed models of surface water extent and daily streamflow were used to represent spatio-temporal variations in hydrological connectivity and surface water persistence within river networks of eastern Australia over a 107-yr period. Using this information, systematic conservation planning was applied to prioritize aquatic areas for conservation of 25 fish species under two scenarios. One scenario identified priority refuges to complement those already occurring in protected areas, whereas the other did not consider protected area status. The priority networks identified concentrated on the main stems of river catchments where surface water was more likely to be persistent and aquatic refuges were more likely to be connected, but also included headwaters for rare fish species. All three set conservation targets for the 25 fish species can be met in the best solution of priority networks. Although the second scenario achieved the targets with a smaller size of priority network overall, it required more new aquatic refuges and was thus less efficient than the first scenario. The newly developed datasets are useful for freshwater conservation prioritization because they account for hydrological variability of intermittent streams. The systematic prioritization approach applied is transferable to other regions and freshwater taxa to identify aquatic refuges for biodiversity conservation within intermittent stream systems.
title: ADCO, Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.1 (début XIIIe siècle), Cart. 166 (11 H 64), 136 folios, f. 0061r
Creators: name: de la Côte d'Or, Archives départementales
name: CG21/F.PETOT/2012
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.1 (début XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 166 (11 H 64), 136 folios, f. 0061r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.1 (début XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 166 (11 H 64), 136 folios, f. 0061r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Additional file 1 of The use of outcome data from quality registries to learn and improve; a Dutch nationwide quantitative analysis in five disease areas
Creators: name: Slingerland, Stacey R.
name: Moers, Lise A. M.
name: Medendorp, Niki M.
name: van der Nat, Paul B.
name: Derks, Lineke
name: Timmermans, Marijke J. C.
name: de Keizer, Nicolette
name: ten Dam, Marc
name: Denissen, Geke
name: van Veghel, Dennis
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Marine Biology

description: Supplementary Material 1.
Additional file 1 of What is known about patients’ quality of life with Phenylketonuria and their caregivers? A scoping review
Creators: name: Remor, Eduardo
name: Gabe, Kamilla Mueller
name: Teruya, Katia Irie
name: Doederlein Schwartz, Ida Vanessa
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biological Sciences not elsewhere classified
Cancer
Science Policy
Mental Health

description: Supplementary Material 1
Microbeam Radiation Therapy Controls Local Growth of Radioresistant Melanoma and Treats Out-of-Field Locoregional Metastasis
Creators: name: Trappetti, V
name: Potez, M
name: Fernandez-Palomo, C
name: Volarevic, V
name: Shintani, N
name: Pellicioli, P
name: Ernst, A
name: Haberthür, D
name: Fazzari, JM
name: Krisch, M
name: Laissue, JA
name: Anderson, Robin
name: Martin, OA
name: Djonov, VG
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 3211
subject: Oncology and carcinogenesis

description: Purpose: Synchrotron-generated microbeam radiation therapy (MRT) represents an innovative preclinical type of cancer radiation therapy with an excellent therapeutic ratio. Beyond local control, metastatic spread is another important endpoint to assess the effectiveness of radiation therapy treatment. Currently, no data exist on an association between MRT and metastasis. Here, we evaluated the ability of MRT to delay B16F10 murine melanoma progression and locoregional metastatic spread. Methods and Materials: We assessed the primary tumor response and the extent of metastasis in sentinel lymph nodes in 2 cohorts of C57BL/6J mice, one receiving a single MRT and another receiving 2 MRT treatments delivered with a 10-day interval. We compared these 2 cohorts with synchrotron broad beam-irradiated and nonirradiated mice. In addition, using multiplex quantitative platforms, we measured plasma concentrations of 34 pro- and anti-inflammatory cytokines and frequencies of immune cell subsets infiltrating primary tumors that received either 1 or 2 MRT treatments. Results: Two MRT treatments were significantly more effective for local control than a single MRT. Remarkably, the second MRT also triggered a pronounced regression of out-of-radiation field locoregional metastasis. Augmentation of CXCL5, CXCL12, and CCL22 levels after the second MRT indicated that inhibition of melanoma progression could be associated with increased activity of antitumor neutrophils and T-cells. Indeed, we demonstrated elevated infiltration of neutrophils and activated T-cells in the tumors after the second MRT. Conclusions: Our study highlights the importance of monitoring metastasis after MRT and provides the first MRT fractionation schedule that promotes local and locoregional control with the potential to manage distant metastasis.
Deposits of disease-associated alpha-synuclein may be present in the dura mater in Lewy body disorders: implications for potential inadvertent transmission by surgery
Creators: name: Gelpi, Ellen
name: Visanji, Naomi P.
name: Hönigschnabl, Selma
name: Reiner, Angelika
name: Fischer, Peter
name: Lang, Anthony
name: Budka, Herbert
name: Kovacs, Gabor G.
Publisher: name: Free Neuropathology
Year: 2020

description: Deposition of alpha-synuclein in the brain is a hallmark of Lewy body disorders. Alpha-synuclein has been considered to show prion-like properties. Prion diseases can be transmitted by the transplantation of cadaveric dura mater causing iatrogenic Creutzfeldt-Jakob disease. Recent observations of amyloid-β deposition in dural grafts support the seeding properties of amyloid-β. Here we assessed the presence of alpha-synuclein in dura mater samples as a potential transmissible seed source. We immunostained 32 postmortem dura mater samples; 16 cases with Lewy-body disorder (LBD) showing different pathology stages and 16 non-LBD cases for phosphorylated (Ser129) and disease-associated (5G4) alpha-synuclein. Disease-associated alpha-synuclein aggregates were identified in intradural nerve fibres and associated with a vessel in a single LBD-Braak stage 4 case. We conclude that alpha-synuclein is detectable, although rarely, in dura mater samples in patients with LBD. The risk of potential transmissibility of dural alpha-synuclein deserves assessment by complementary experimental studies.
description: Free Neuropathology, Bd. 1 (2020)
Additional file 2 of The use of outcome data from quality registries to learn and improve; a Dutch nationwide quantitative analysis in five disease areas
Creators: name: Slingerland, Stacey R.
name: Moers, Lise A. M.
name: Medendorp, Niki M.
name: van der Nat, Paul B.
name: Derks, Lineke
name: Timmermans, Marijke J. C.
name: de Keizer, Nicolette
name: ten Dam, Marc
name: Denissen, Geke
name: van Veghel, Dennis
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Marine Biology

description: Supplementary Material 2.
The effects of concurrent bilateral anodal tDCS of primary motor cortex and cerebellum on corticospinal excitability: a randomized, double-blind sham-controlled study
Creators: name: Behrangrad, S
name: Zoghi, Maryam
name: Kidgell, D
name: Mansouri, F
name: Jaberzadeh, S
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 3209
subject: Neurosciences
subject: FOS: Clinical medicine

description: Transcranial direct current stimulation (tDCS) applied to the primary motor cortex (M1), and cerebellum (CB) can change the level of M1 corticospinal excitability (CSE). A randomized double-blinded crossover, the sham-controlled study design was used to investigate the effects of concurrent bilateral anodal tDCS of M1 and CB (concurrent bilateral a-tDCSM1+CB) on the CSE. Twenty-one healthy participants were recruited in this study. Each participant received anodal-tDCS (a-tDCS) of 2 mA, 20 min in four pseudo-randomized, counterbalanced sessions, separated by at least 7 days (7.11 days ± 0.65). These sessions were bilateral M1 stimulation (bilateral a-tDCSM1), bilateral cerebellar stimulation (bilateral a-tDCSCB), concurrent bilateral a-tDCSM1+CB, and sham stimulation (bilateral a-tDCSSham). Transcranial magnetic stimulation (TMS) was delivered over the left M1, and motor evoked potentials (MEPs) of a contralateral hand muscle were recorded before and immediately after the intervention to measure CSE changes. Short-interval intracortical inhibition (SICI), intracortical facilitation (ICF), and long interval intracortical inhibition (LICI) were assessed with paired-pulse TMS protocols. Anodal-tDCS significantly increased CSE after concurrent bilateral a-tDCSM1+CB and bilateral a-tDCSCB. Interestingly, CSE was decreased after bilateral a-tDCSM1. Respective alterations in SICI, LICI, and ICF were seen, including increased SICI and decreased ICF, which indicate the involvement of glutamatergic and GABAergic systems in these effects. These results confirm that the concurrent bilateral a-tDCSM1+CB have a facilitatory effect on CSE, whereas bilateral a-tDCSM1 exert some inhibitory effects. Moreover, the effects of the 2 mA, 20 min a-tDCS on the CB were consistent with its effects on the M1.
Statistical Plan
Creators: name: Damluji, Abdulla A.
name: DeFilippi, Christopher
name: Bruce, Scott
Publisher: name: OSF Registries
Year: 2022

description: We propose to measure circulating biomarkers at baseline, and their change over 3 months, representing generalized inflammation, renal function, ventricular wall stress, and myocyte cell injury. Given recent evidence identifying that the cardiac isoform of troponin T is re-expressed in diseased skeletal muscle we will also aim to evaluate whether measuring the circulating cardiac isoforms for troponin I and T can provide insight into improvements in skeletal muscle function.9 Utilizing previously frozen serum samples from pre-randomization and at 3 months following completion of physical rehabilitation from the REHAB-HF study we propose the following mechanistic and prognostic aims.
title: 14 - Hebammen und Frauen in der Hauptrolle
Creators: name: Bogner, Katrin
name: Wahl, Theresa
Publisher: name: Universitätsklinikum
Year: 2025
Subjects: subject: Hebamme
subject: Kreißsaal
subject: Hebammenkreißsaal
subject: Geburt
subject: Säugling
subject: Schwangerschaft
subject: 610

description: Am UKJ gibt es einen hebammengeleiteten Kreißsaal, das heißt: Die Hebammen begleiten gesunde Mamas bei unkomplizierten Geburten ganz eigenverantwortlich, ohne ärztliches Eingreifen. Wie der hebammengeleitete Kreißsaal funktioniert, wer dort entbinden kann und wie die Geburten für Hebammen und Mamas sind, darüber sprechen Claudia Hahnemann, leitende Hebamme im Kreißsaal des UKJ, und Hebamme Jasmin Holland. Weitere Informationen: Hebammenkreißsaal
description: REZEPTFREI – Die UKJ-Erklärsprechstunde
A Comprehensive Review of High-Pressure Laser-Induced Materials Processing, Part II: Laser-Driven Dynamic Compression within Diamond Anvil Cells
Creators: name: Alabdulkarim, Mohamad Emad M
name: Maxwell, Wendy D
name: Thapliyal, Vibhor
name: Maxwell, James
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 4016
subject: Materials engineering
subject: FOS: Materials engineering
classificationCode: 4017
subject: Mechanical engineering
subject: FOS: Mechanical engineering

description: The field of high-pressure materials research has grown steadily over the last seven decades, with many remarkable discoveries having been made. This work is part II of a three-part series summarising recent progress in laser material processing within diamond anvil cells (L-DACs); this article focuses on the practice of laser-driven dynamic compression within diamond anvil cells (i.e., LDC–DAC experimentation). In this case, materials are initially pre-compressed within diamond anvil cells, then further dynamically compressed through the use of a high-power pulsed laser, often with the intent to isentropically compress, rather than to heat samples. The LDC–DAC approach provides a novel route to much higher dynamic pressures (approaching 1 TPa), as compared to conventional static compression within a single-stage DAC (<300 GPa) and provides a route to mapping Hugoniot curves. Recent proliferation of low-cost, high-power laser sources has led to increased research activity in LDC–DAC materials processing over the last two decades. Through LDC–DAC experiments, a greater understanding of the properties/structure of cold- and warm-dense matter has been obtained, and novel material phases have been realised. In this article, LDC–DAC experimental methods are reviewed, together with the underlying physics of laser dynamic compression in confined spaces. In addition, a chronology of important events in the development of LDC–DAC processing is provided, and emerging trends, gaps in knowledge, and suggestions for further work are considered.
Understanding artifact variability and function in the evolution of human behavior: Introducing the Laboratory for Traceology and Controlled Experiments (TraCEr)
Creators: name: Marreiros, Joao
name: Calandra, Ivan
name: Gneisinger, Walter
Publisher: name: figshare
Year: 2017
Subjects: subject: Archaeology
subject: 210102 Archaeological Science
subject: FOS: History and archaeology

description: Understanding artifact variability, and especially the role of different raw materials and their possibleuse by past humans, is one of the most debated topics in Pleistocene archaeo logy. Functional studiesare critical to determine artifact use, and thus to address fundamental questions about the evolutionof human behaviour.The new Laboratory for Traceology and Controlled Experiments (TraCEr) is basedat the MONREPOS Archaeological Research Centre and Museum for HumanBehavioural Evolution. Its goal is to carry out ground-breaking func tio nalstudies that combine 1) methodological development and2) fundamental research on Pleistocene and Early Holocene archaeology.
Additional file 1 of From host individual traits to community structure and composition: Bartonella infection insights
Creators: name: Cruz, Gabriella Lima Tabet
name: Gonçalves-Oliveira, Jonathan
name: de Lemos, Elba Regina Sampaio
name: D’Andrea, Paulo Sergio
name: de Andreazzi, Cecilia Siliansky
Publisher: name: figshare
Year: 2024
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Additional file 1: Fig. S1 Rényi’s diversity profiles of the rodent communities sampled in ten municipalities in Rio de Janeiro state, Brazil. Table S1 Summary of the number of communities, individuals and species studied at the three different levels of the analyses. Table S2 Functional diversity indices models using the odds ratio of Bartonella infection (logit-transformed) as the response variable between rodent communities in the state of Rio de Janeiro, Brazil. Table S3 Phylogenetic generalized linear mixed models predicting the status of Bartonella infection between rodent individuals of the Atlantic Forest (n = 192 after removing missing values). Table S4 Multiple regression coefficients for species interaction distance matrices, considering the presence and absence of Bartonella per host species and their phylogenetic and trait profile distances. Table S5 Properties of network node: values of degree and betweenness centralities. Table S6 Full ranking of candidate generalized linear models predicting degree centrality. Table S7 Full ranking of candidate generalized linear models predicting betweenness centrality.
LTER Slowinski Nationalpark, Poland, Vegetation data 2001-2018
Creators: name: [Unknown]
Publisher: name: FZ-Juelich B2SHARE
Year: 2020

description: Vegetation survey data of the 6,3 ha study area Slowiński National Park, Poland (LTER_EU_PL_014) between the years 2001 and 2018. The percentage cover of every vascular plant was determined on permanently marked subplots (25 m²) in the 90-year-old spruce and pine stand.
Standard survey
Creators: name: Heather, Amy
name: Pitt, Martin
name: Hobbs, Tim
name: Davis, George
name: Oakley, Ava
name: Potter, Katie
name: Immy Rimington
Publisher: name: OSF Registries
Year: 2024

description: Description of the standard #BeeWell survey delivered by Kailo, including the full content of the survey.
Additional file 1 of Experiences of mothers of long-term surviving patients with cerebral adrenoleukodystrophy: a qualitative study
Creators: name: Koto, Yuta
name: Hadano, Nozomi
name: Sakai, Norio
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 1
Birds and insects respond differently to combinations of semi-natural features in farm landscapes
Creators: name: Hall, MA
name: Nimmo, DG
name: Bennett, Andrew
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 4104
subject: Environmental management
classificationCode: 3103
subject: Ecology
subject: FOS: Biological sciences
classificationCode: 3109
subject: Zoology

description: Semi-natural features among farmland have a key role in maintaining wildlife in rural landscapes. Practical conservation requires knowledge of which combinations of features are of greatest value and whether this differs among faunal groups. We used a ‘landscape’ approach to investigate the relative importance to birds and insects (bees, flies, wasps) of combinations of three wooded features typical of farmland in south-eastern Australia: scattered trees, wooded roadsides and wooded streamside vegetation. We selected 44 landscapes (1 km diameter) representing four combinations: (a) landscapes with all three features present, (b) landscapes lacking scattered trees, (c) lacking wooded roadsides and (d) lacking wooded streamsides. We surveyed birds and selected insects, and compared mean alpha (α, site), beta (β, between site) and gamma (γ, landscape) diversity for each taxon between landscape types; and gamma (γ) diversity of bird species displaying breeding activity. Mean α-diversity of birds was reduced in landscapes lacking wooded roadsides or streams, relative to those with all three wooded features; while species differentiation (β-diversity) increased in these landscapes. Loss of streamside vegetation had the greatest landscape-scale impact, reducing γ-diversity by ~33% for all land-birds and ~50% for woodland birds. Bird breeding activity declined by ~50% in landscapes lacking wooded streamsides. In contrast, insects showed little response, except bees for which mean α-diversity was greater in more open landscapes lacking scattered trees or wooded roadsides, compared with those containing all wooded features. This did not lead to differences in landscape-level (γ) diversity. Synthesis and applications. Birds and insects respond differently to combinations of semi-natural features in rural landscapes, highlighting the need to better meet the requirements of multiple faunal groups in nature conservation activities. Wooded features, especially streamside vegetation, are critical for maintaining diversity and breeding activity of woodland birds. Given a general lack of knowledge of the insect fauna in some regions and varied results here, a prudent approach is to foster a diverse farmland mosaic comprising semi-natural habitats together with floristically rich, modified features that provide temporally dynamic resources. These combined landscape features are important for faunal conservation, while also supporting farm productivity and ecosystem services.
title: ADCO, Cartulaire de Cîteaux pour les possessions de Chaugey et Maison-Dieu (Fin XVe siècle), Cart. 181 (11 H 754), 165 folios, f. 0151
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2017
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire de Cîteaux pour les possessions de Chaugey et Maison-Dieu (Fin XVe siècle), Archives départementales de la Côte-d'Or, Cart. 181 (11 H 754), 165 folios, f. 0151, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les possessions de Chaugey et Maison-Dieu (Fin XVe siècle), Archives départementales de la Côte-d'Or, Cart. 181 (11 H 754), 165 folios, f. 0151, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Additional file 1 of Spiny mice are primed but fail to regenerate volumetric skeletal muscle loss injuries
Creators: name: Davenport, Mackenzie L.
name: Fong, Amaya
name: Albury, Kaela N.
name: Henley-Beasley, C. Spencer
name: Barton, Elisabeth R.
name: Maden, Malcolm
name: Swanson, Maurice S.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Astronomical and Space Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Computational Biology

description: Supplementary Material 1.
A Retrospective Cohort Study of Women and Men Living with HIV, Attending an HIV Clinic in Australia
Creators: name: Hamilton, Rochelle
name: Wells, Yvonne
name: Higgs, Peter
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 4206
subject: Public health

description: Objectives: To compare women with men presenting with HIV to a public health HIV clinic, to identify the special characteristics and health care needs of women living with HIV in the Barwon South West region in Victoria. Methods: A retrospective cohort study of 35 women and 135 men living with HIV who attended the clinic between 2009 and 2020. Gender differences were assessed using nonparametric analyses. Results: The women were diagnosed with HIV younger than the men (mean 29.5 years vs. 36.7 years) and more were born in Africa (28.6% vs. 5.2%). More men than women presented with sexually transmittable infections (38.5% vs. 14.3%) at the time of diagnosis, and were diagnosed through a sexual health screen (37% vs. 17%). The proportions of men and women who used alcohol and other drugs (recent to their diagnosis) were similar (68.1% vs. 48.6%), and there was no difference in proportions presenting with AIDS-defining illnesses (p = 0.425), or CD4 cell count (advanced: £200 cells, relatively well: ‡201 cells, p = 0.241), but the women had a lower viral load (p < 0.001). Conclusions: In this study of 170 people living with HIV, nearly one-half of the men with known HIV history were diagnosed through sexual health screens, but women’s HIV was mostly detected through targeted screening. Results highlight gender disparity in access to sexual health screening and assessment, including low awareness of sexual health risks for women, and endorse the view that HIV is a heterosexual sexually transmittable infection in women.
Slides SUNRISE partners
Creators: name: WP3 Dissemination, communication and outreach
Publisher: name: Zenodo
Year: 2019
Subjects: short presentation - 3 slides

description: SUNRISE partners have been very engaged and active introducing the initiative at the numerous conferences, workshops and meetings in which they have participated. For events at which only one slide or very few ones could be shown, a one-slide summary
 or a three-slide presentation were also made available to the consortium partners in order to get a snapshot of SUNRISE initiative.
Additional file 1 of The Post-Stroke Checklist: longitudinal use in routine clinical practice during first year after stroke
Creators: name: Månsson, Kristina
name: Söderholm, Martin
name: Berhin, Ida
name: Pessah-Rasmussen, Hélène
name: Ullberg, Teresa
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Mental Health
subject: Computational Biology

description: Supplementary Material 1
Development and application of bioinformatics tools for protein loop modelling
Creators: name: Hernandez, Ivan Martin
Publisher: name: Zenodo
Year: 2019
Subjects: Bioinfomatic tools
RCD
KOPR
Loop modelling
CDR
H3 loops

description: Master thesis of Ivan Martin Hernandez in the MSc of Computational Biology of the Polytechnic University of Madrid (UPM) in June of 2019. It has been developed in the Chacon lab (http://chaconlab.org/) at the Rocasolano Institute of Physics-Chemistry (IFQR) a part of the "Consejo Superior de Investigaciones Cientificas (CSIC)".
Additional file 2 of The Post-Stroke Checklist: longitudinal use in routine clinical practice during first year after stroke
Creators: name: Månsson, Kristina
name: Söderholm, Martin
name: Berhin, Ida
name: Pessah-Rasmussen, Hélène
name: Ullberg, Teresa
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Mental Health
subject: Computational Biology

description: Supplementary Material 2
Additional file 1 of Periodontal disease and cardiovascular disease: umbrella review
Creators: name: Arbildo-Vega, Heber Isac
name: Cruzado-Oliva, Fredy Hugo
name: Coronel-Zubiate, Franz Tito
name: Meza-Málaga, Joan Manuel
name: Luján-Valencia, Sara Antonieta
name: Luján-Urviola, Eduardo
name: Echevarria-Goche, Adriana
name: Farje-Gallardo, Carlos Alberto
name: Castillo-Cornock, Tania Belú
name: Serquen-Olano, Katherine
name: Padilla-Cáceres, Tania
name: Caballero-Apaza, Luz
name: Aguirre-Ipenza, Rubén
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Science Policy

description: Supplementary Material 1. Overlapping of primary studies in systematic reviews.
Relationships of APOE Genotypes with Small RNA and Protein Cargo of Brain Tissue Extracellular Vesicles from Patients with Late-Stage AD
Creators: name: Huang, Y
name: Driedonks, TAP
name: Sim, Lesley
name: Rajapaksha, Kolin
name: Turchinovich, A
name: Routenberg, DA
name: Nagaraj, R
name: Redding-Ochoa, J
name: Arab, T
name: Powell, BH
name: Pletnikova, O
name: Troncoso, JC
name: Zheng, L
name: Hill, Andrew
name: Mahairaki, V
name: Witwer, KW
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 3202
subject: Clinical sciences
classificationCode: 3105
subject: Genetics
subject: FOS: Biological sciences
classificationCode: 3209
subject: Neurosciences
subject: FOS: Clinical medicine

description: Background and Objectives: Variants of the apolipoprotein E (APOE) gene are the greatest known risk factors for sporadic Alzheimer disease (AD). Three major APOE isoform alleles, ϵ2, ϵ3, and ϵ4, encode and produce proteins that differ by only 1-2 amino acids but have different binding partner interactions. Whereas APOE ϵ2 is protective against AD relative to ϵ3, ϵ4 is associated with an increased risk for AD development. However, the role of APOE in gene regulation in AD pathogenesis has remained largely undetermined. Extracellular vesicles (EVs) are lipid bilayer-delimited particles released by cells to dispose of unwanted materials and mediate intercellular communication, and they are implicated in AD pathophysiology. Brain-derived EVs (bdEVs) could act locally in the tissue and reflect cellular changes. To reveal whether APOE genotype affects EV components in AD brains, bdEVs were separated from patients with AD with different APOE genotypes for parallel small RNA and protein profile. Methods: bdEVs from late-stage AD brains (BRAAK stages 5-6) from patients with APOE genotypes ϵ2/3 (n = 5), ϵ3/3 (n = 5), ϵ3/4 (n = 6), and ϵ4/4 (n = 6) were separated using our published protocol into a 10,000g pelleted extracellular fraction (10K) and a further purified EV fraction. Counting, sizing, and multiomic characterization by small RNA sequencing and proteomic analysis were performed for 10K, EVs, and source tissue. Results: Comparing APOE genotypes, no significant differences in bdEV total particle concentration or morphology were observed. Overall small RNA and protein profiles of 10K, EVs, and source tissue also did not differ substantially between different APOE genotypes. However, several differences in individual RNAs (including miRNAs and tRNAs) and proteins in 10K and EVs were observed when comparing the highest and lowest risk groups (ϵ4/4 and ϵ2/3). Bioinformatic analysis and previous publications indicate a potential regulatory role of these molecules in AD. Discussion: For patients with late-stage AD in this study, only a few moderate differences were observed for small RNA and protein profiles between APOE genotypes. Among these, several newly identified 10K and EV-associated molecules may play roles in AD progression. Possibly, larger genotype-related differences exist and are more apparent in or before earlier disease stages.
title: ADCO, Sixième cartulaire de Saint-Étienne de Dijon (1662), Cart. 30 (G 133), 441 folios, f. 726
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Sixième cartulaire de Saint-Étienne de Dijon (1662), Archives départementales de la Côte-d'Or, Cart. 30 (G 133), 441 folios, f. 726, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Sixième cartulaire de Saint-Étienne de Dijon (1662), Archives départementales de la Côte-d'Or, Cart. 30 (G 133), 441 folios, f. 726, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Additional file 2 of Lactuca super-pangenome reduces bias towards reference genes in lettuce research
Creators: name: van Workum, Dirk-Jan M.
name: Mehrem, Sarah L.
name: Snoek, Basten L.
name: Alderkamp, Marrit C.
name: Lapin, Dmitry
name: Mulder, Flip F. M.
name: Van den Ackerveken, Guido
name: de Ridder, Dick
name: Schranz, M. Eric
name: Smit, Sandra
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 2: Supplementary figure S1) Functional enrichment of core Lactuca genes. Supplementary figure S2) Functional enrichment of variable Lactuca genes. Supplementary figure S3) CNV in the RLL2B gene in L. sativa. Supplementary figure S4) Completeness assessment for both v8 and v11 of L. sativa var. Salinas proteome.
Do recovery-oriented messages improve self-efficacy and positive emotions amongst people with lived experience of psychosis? Experimental investigation
Creators: name: McLeod, B
name: Meyer, C
name: Meyer, D
name: Nunan, C
name: Murray, G
name: Farhall, John
name: Thomas, N
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 5205
subject: Social and personality psychology
classificationCode: 5202
subject: Biological psychology
classificationCode: 5203
subject: Clinical and health psychology

description: Objectives: Recovery-oriented perspectives have become accepted worldwide as an alternative to the biomedical approach to conceptualizing and managing severe mental health problems. It has been proposed that one advantage of this is to support self-efficacy amongst people with a lived experience of psychosis, especially when recovery messages are presented by lived experience peers. The aim of the present study was to investigate the proposed psychological benefits of the recovery paradigm, by testing for possible differential impacts of recovery versus biomedical messages on self-efficacy beliefs and positive emotional state amongst people with experience of psychosis. It was hypothesized that (1) recovery-oriented messages, when presented by lived experience peers, would generate improvements in self-efficacy and positive emotions relative to biomedical messages presented by a professional and (2) recovery-oriented messages delivered by a professional would generate improvements in self-efficacy and positive emotions relative to biomedical messages delivered by a professional. We also explored whether recovery-oriented messages were more impactful when delivered by a lived experience peer versus a professional. Design: Experimental design with three within-subject video-based conditions. Methods: Fifty-three participants with lived experience of psychosis viewed three videos: (i) people with lived experience sharing their experiences of recovery; (ii) mental health professionals presenting traditional biomedical conceptualizations of psychosis; and (iii) mental health professionals presenting recovery perspectives. Participants provided baseline clinical and demographic information, and post-viewing ratings of experienced changes in self-efficacy and emotional state. Results: Hypothesis 1 was supported: both self-efficacy and positive emotions were significantly increased by a video of peers sharing personal recovery stories relative to professionals presenting biomedical messages. Hypothesis 2 was partially supported: when comparing videos of recovery versus biomedical messages delivered by professionals, significant relative benefits were found for positive emotions, but not self-efficacy. Conclusions: This experimental investigation generated a pattern of findings broadly supportive of the assumed psychological benefits of the recovery paradigm for people with lived experiences of psychosis. Findings must be interpreted with caution given the limitations of the present design, but encourage further experimental research to directly test the interpersonal impacts of the recovery paradigm.
Additional file 3 of Lactuca super-pangenome reduces bias towards reference genes in lettuce research
Creators: name: van Workum, Dirk-Jan M.
name: Mehrem, Sarah L.
name: Snoek, Basten L.
name: Alderkamp, Marrit C.
name: Lapin, Dmitry
name: Mulder, Flip F. M.
name: Van den Ackerveken, Guido
name: de Ridder, Dick
name: Schranz, M. Eric
name: Smit, Sandra
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 3: Supplementary methods) Additional information about the key steps we took in the methods and the reasoning behind them.
Investigation on Causes And Impacts of Claim & Risk on The Project Schedule : A Case Ethiopian Kenya Power System interconnection Project Wolayta Sodo Substation Construction
Creators: name: Abebe, Hana
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2020
Subjects: Claim, causes of claims, impacts of claims & risks, Ethiopia- Kenya Electricity Project

description: Claims are an inevitable fact of life in the construction industry. Whether in local or
 International contract projects, the issue of claims remains the same. In the context of
 civil engineering projects, claims are a demand for money or time extension or both to
 which one party rightly or wrongly assume that he has a right. Current practice of the
 construction industry shows that it is a rare event most construction projects are
 completed on the scheduled time, budgeted cost, and desired quality. The main reason
 behind is that construction projects are unique in nature and they are full of
 uncertainties. As a result, claims and disputes become common phenomena especially
 on large civil engineering contracts.
 This thesis addresses investigating causes and impacts of claim and risk on the project
 schedule in Ethiopia- Kenya Electricity Project Wolayta Sodo Convertor Station.
 Understanding the causes will be useful to managing claims in terms of recognition,
 mitigation and early resolution.
 The study has two main sections: the first part is an overview and discussions of
 concepts and contextual practices of claims, risks and contracts. In the second part, a
 case study and questionnaires are made primarily to assess the causes of claims and
 risks associated in Ethiopia- Kenya Electricity Project Wolayta Sodo Convertor
 Station. In addition, this study (especially the survey questionnaires) also assesses the
 current practices of the construction firm and parties in mitigating and/or
 administering claims; and this study clearly shows the impacts of claim and risk on
 the project schedule by using Primavera Risk Analysis Software.
 This study concludes that the causes of claims in Ethiopia- Kenya Electricity Project
 Wolayta Sodo Convertor Station are many and the major causes are change in design
 and specification, delay in completion of time, extra work, sub-contractors delay;
 shortage and problem related to delivery of raw materials and inadequate
 investigation before bidding. Moreover, the contractor submit time extension claim
 only so time overrun was the only effect; resource and manpower to extend the
 working hours to 10 hours, working 6 days a week, working extra shifts and night
 time works, priorities project resources, renegotiate internal company project priority
 and keep key resource update with the latest schedule are the mitigation mechanisms
 on this project. Hence, this thesis gives recommendations anticipatory approaches that help to
 minimize the incidence of claims and improve the management of construction
 claims.
ImmunoPET: IMaging of cancer imMUNOtherapy targets with positron Emission Tomography: a phase 0/1 study characterising PD-L1 with 89 Zr-durvalumab (MEDI4736) PET/CT in stage III NSCLC patients receiving chemoradiation study protocol
Creators: name: Hegi-Johnson, F
name: Rudd, SE
name: Wichmann, Christian
name: Akhurst, T
name: Roselt, P
name: Trinh, J
name: John, T
name: Devereux, L
name: Donnelly, PS
name: Hicks, R
name: Scott, Andrew
name: Steinfort, D
name: Fox, S
name: Blyth, B
name: Parakh, Sagun
name: Hanna, GG
name: Callahan, J
name: Burbury, K
name: MacManus, M
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 52
subject: Psychology
subject: FOS: Psychology
classificationCode: 3211
subject: Oncology and carcinogenesis
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences

description: Background: ImmunoPET is a multicentre, single arm, phase 0-1 study that aims to establish if 89 Zr-durvalumab PET/CT can be used to interrogate the expression of PD-L1 in larger, multicentre clinical trials. Methods: The phase 0 study recruited 5 PD-L1+ patients with metastatic non-small cell lung cancer (NSCLC). Patients received 60MBq/70 kg 89 Zr-durva up to a maximum of 74 MBq, with scan acquisition at days 0, 1, 3 or 5±1 day. Data on (1) Percentage of injected 89 Zr-durva dose found in organs of interest (2) Absorbed organ doses (μSv/MBq of administered 89 Zr-durva) and (3) whole-body dose expressed as mSv/100MBq of administered dose was collected to characterise biodistribution. The phase 1 study will recruit 20 patients undergoing concurrent chemoradiotherapy for stage III NSCLC. Patients will have 89 Zr-durva and FDG-PET/CT before, during and after chemoradiation. In order to establish the feasibility of 89 Zr-durva PET/CT for larger multicentre trials, we will collect both imaging and toxicity data. Feasibility will be deemed to have been met if more than 80% of patients are able complete all trial requirements with no significant toxicity. Ethics and dissemination: This phase 0 study has ethics approval (HREC/65450/PMCC 20/100) and is registered on the Australian Clinical Trials Network (ACTRN12621000171819). The protocol, technical and clinical data will be disseminated by conference presentations and publications. Any modifications to the protocol will be formally documented by administrative letters and must be submitted to the approving HREC for review and approval. Trial registration number: Australian Clinical Trials Network ACTRN12621000171819.
Dynamic ROS control by TIGAR regulates the initiation and progression of pancreatic cancer.
Creators: name: Cheung, Eric C
name: DeNicola, Gina M
name: Nixon, Colin
name: Blyth, Karen
name: Labuschagne, Christiaan F
name: Tuveson, David A
name: Vousden, Karen H
Publisher: name: The Francis Crick Institute
Year: 2020
Subjects: Signalling & Oncogenes
Metabolism
Cell Biology

description: The TIGAR protein has antioxidant activity that supports intestinal tissue repair and adenoma development. Using a pancreatic ductal adenocarcinoma (PDAC) model, we show that reactive oxygen species (ROS) regulation by TIGAR supports premalignant tumor initiation while restricting metastasis. Increased ROS in PDAC cells drives a phenotypic switch that increases migration, invasion, and metastatic capacity. This switch is dependent on increased activation of MAPK signaling and can be reverted by antioxidant treatment. In mouse and human, TIGAR expression is modulated during PDAC development, with higher TIGAR levels in premalignant lesions and lower TIGAR levels in metastasizing tumors. Our study indicates that temporal, dynamic control of ROS underpins full malignant progression and helps to rationalize conflicting reports of pro- and anti-tumor effects of antioxidant treatment.
Relationships of Motor Changes with Cognitive and Neuropsychiatric Features in FMR1 Male Carriers Affected with Fragile X-Associated Tremor/Ataxia Syndrome
Creators: name: Hocking, Darren
name: Loesch-Mdzewska, Danuta
name: Stimpson, Paige
name: Tassone, Flora
name: Atkinson, Anna
name: Storey, Elsdon
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 3209
subject: Neurosciences
subject: FOS: Clinical medicine
classificationCode: 5202
subject: Biological psychology
classificationCode: 5201
subject: Applied and developmental psychology

description: The premutation expansion of the Fragile X Messenger Ribonucleoprotein 1 (FMR1) gene on the X chromosome has been linked to a range of clinical and subclinical features. Nearly half of men with FMR1 premutation develop a neurodegenerative disorder; Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS). In this syndrome, cognitive executive decline and psychiatric changes may co-occur with major motor features, and in this study, we explored the interrelationships between these three domains in a sample of adult males affected with FXTAS. A sample of 23 adult males aged between 48 and 80 years (mean = 62.3; SD = 8.8), carrying premutation expansions between 45 and 118 CGG repeats, and affected with FXTAS, were included in this study. We employed a battery of cognitive assessments, two standard motor rating scales, and two self-reported measures of psychiatric symptoms. When controlling for age and/or educational level, where appropriate, there were highly significant correlations between motor rating score for ICARS gait domain, and the scores representing global cognitive decline (ACE-III), processing speed (SDMT), immediate memory (Digit Span), and depression and anxiety scores derived from both SCL90 and DASS instruments. Remarkably, close relationships of UPDRS scores, representing the contribution of Parkinsonism to FXTAS phenotypes, were exclusive to psychiatric scores. Highly significant relationships between CGG repeat size and most scores for three phenotypic domains suggest a close tracking with genetic liability. These findings of relationships between a constellation of phenotypic domains in male PM carriers with FXTAS are reminiscent of other conditions associated with disruption to cerebro-cerebellar circuits.