cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Using systems thinking to investigate the sustainability of digital fabrication projects in the humanitarian and development sector
Creators: name: Corsini, L
name: Moultrie, J
Publisher: name: Inderscience Publishers
Year: 2022
Subjects: 3503 Business Systems In Context
35 Commerce, Management, Tourism and Services
3507 Strategy, Management and Organisational Behaviour
Generic health relevance

description: Recently, designers have started using digital fabrication to create new solutions to meet global challenges. However, many technology projects in the humanitarian and development sector have been criticised for failing to deliver sustainable solutions. This study responds to these concerns by investigating the sustainability of digital fabrication projects in the humanitarian and development sector. A systems approach is used to synthesise knowledge from 14 digital fabrication projects in healthcare, education and water and sanitation. Causal loop diagrams are created to investigate the relationships between the drivers and barriers to sustainability. Several systems archetypes are also identified revealing potential leverage points for driving more sustainable solutions. The paper contextualises these findings by drawing on theories from participatory development and cosmopolitan localism. It concludes that digital fabrication presents an opportunity for more local and participatory design; however, sustainability is being undermined by a tendency to seek short-term solutions.
Turritellidae
Creators: name: Leal, José H.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Turritellidae

description: Family Turritellidae
Turritella lyonsi García, 2006 (Figure 17); two paratypes.
description: Published as part of Leal, José H., 2021, Type specimens in the molluscan collection of the Bailey-Matthews National Shell Museum, Florida, USA, pp. 1-40 in Zootaxa 4951 (1) on page 4, DOI: 10.11646/zootaxa.4951.1.1, http://zenodo.org/record/4655535
Hesperocythere Hart & Hart 1967
Creators: name: Williams, Bronwyn W.
name: Weaver, Patricia G.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Hesperocythere

description: Hesperocythere Hart & Hart, 1967
1967b Hesperocythere gen nov.—Hart & Hart: 7, 29, 50 [by implication], 51, Fig. 93 (D, K, T).
1974 Hesperocythere Hart and Hart, 1967.—Hart & Hart: viii, 145, 151, Fig. 44 (C, D, H, K, T).
1974 Hesperocythere Hart and Hart, 1967.—Hartmann & Puri: 51 (C).
1975 Hesperocythere Hart & Hart, 1967.—Hart & Hart: 56 (C, D, H).
description: Published as part of Williams, Bronwyn W. & Weaver, Patricia G., 2018, A historical review of the taxonomy and classification of Entocytheridae (Crustacea: Ostracoda: Podocopida), pp. 1-129 in Zootaxa 4448 (1) on page 101, DOI: 10.11646/zootaxa.4448.1.1, http://zenodo.org/record/1444492
Medicare expenditure growth and its health returns across cohorts
Creators: name: Chao, Yi-Sheng
Publisher: name: No Publisher Supplied
Year: 2012

description: There are several key findings in the following chapters. In Chapter 2, the individual characteristics associated with higher spending growth over the period 1996 to 2008 were identified based on analyses with pooled cross-sectional data from the Medical Expenditure Panel Survey. The key factors that were associated with the adjusted growth rates higher than the actual Medicare spending growth rate (5.8% annually) from 1996 to 2008 include races other than the whites and blacks, Hispanic origin, high income, residence in the West, and very good health status.   Findings from Chapter 3 reveal that enrollment in HMOs under Medicare is not random, but is systematically related to characteristics of Medicare enrollees. Using the longitudinal Health and Retirement Study, there were factors associated with a higher likelihood of becoming enrolled in Medicare Advantage/Part C.   Chapter 4 examines the relationship between health care spending and returns to health with regard to five dimensions of health: mortality, hypertension, arthritis, self-assessed health status and mental health status (Center for Epidemiologic Studies Depression scale, CESD scale). The pre-Medicare characteristics were used to predict the change in these five dimensions of health after four years of Medicare coverage. The results reveal that increases in Medicare total and out-of-pocket spending were associated with poor health outcomes. Total spending was associated with a higher likelihood of death, worse self-rated health status (five categories) and mental health status. The increase in out-of-pocket health expenditure was associated with a higher chance of getting a worse category in self-rated health status after controlling for health status and other characteristics before being enrolled in Medicare. The findings of these studies suggest that policies to constrain Medicare spending should recognize and target the multiple factors contributing to Medicare expenditure growth and the dubious returns to health, as well as target integrated care for Medicare enrollees and incentives for individuals to prevent the onset of chronic health conditions.
Euplectrus bicolor Swederus
Creators: name: Yefremova, Zoya A.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy

description: 38. Euplectrus bicolor (Swederus)
Material examined. 1 ♀, Israel, Nahal Zin, on Tamarix sp., sweeping, 5.v.1998 (I. Yarom, V. Kravchenko); 2 ♀, Tel Aviv University, M.T., 1.viii.2006 (W. Kuslitzky).
Hosts. Ectoparasitoid of Noctuidae, Geometridae, Gracillariidae (Lepidoptera) (Bouček & Askew 1968). Distribution. Israel *; Nearctic (Peck 1963) and Palearctic (Bouček & Askew 1968; Askew et al. 2001; Zhu & Huang 2003) ecorealms.
description: Published as part of Yefremova, Zoya A., 2015, An annotated checklist of the Eulophidae (excl. Tetrastichinae) (Hymenoptera: Chalcidoidea) of Israel, pp. 1-36 in Zootaxa 3957 (1) on page 11, DOI: 10.11646/zootaxa.3957.1.1, http://zenodo.org/record/288546
Inventaire du fonds Bastaire de littérature populaire et infantine [version 1]. Romans populaires illustrés Second Empire (en fascicules)
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024

description: Numérisation ICB CollEx-Persée AAP20212022
description: Les titres sont ceux donnés par Jean Bastaire. Les dates indiquées ont été établies depuis un courrier de Jean à Michel Bastaire qui lui demandait de dresser l'inventaire. Et la date de fin correspond à la donation et à la publication de Lectures englouties. Listes manuscrites de la collection établie par Jean Bastaire et Michel Bastaire ; Jean sous forme de livrets thématiques et feuilles volantes au format A5. Michel a consigné les titres dans un carnet bloc type Rhodia format A6.
description: Source: Fonds Bastaire Université Clermont Auvergne (Bas-G08_D067)
description: Relation: http://www.calames.abes.fr/pub/ms/_631139801_Bas-G08_D067
description: created: 1993/2008
Euplectrus flavipes Fonscolombe
Creators: name: Yefremova, Zoya A.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy

description: 39. Euplectrus flavipes (Fonscolombe)
Material examined. 1 ♀, Israel, Mahanayim, sweeping, 5.v.1975 (F. Kaplan).
Hosts. Ectoparasitoid of Laphygma sp. (Lepidoptera: Noctuidae) (Zhu & Huang 2003). Distribution. Israel *; Nearctic (Mexico) (Zhu & Huang 2003) and Palearctic (Askew et al. 2001; Zhu & Huang 2003; Boyadzhiev 2006) ecorealms.
description: Published as part of Yefremova, Zoya A., 2015, An annotated checklist of the Eulophidae (excl. Tetrastichinae) (Hymenoptera: Chalcidoidea) of Israel, pp. 1-36 in Zootaxa 3957 (1) on page 11, DOI: 10.11646/zootaxa.3957.1.1, http://zenodo.org/record/288546
A Novel Drug Induces Apoptosis in Breast Cancer Cells
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Despite the development of new chemotherapeutic agents and aggressive treatment regimens, improvements in the long-term survival for breast cancer patients has been disappointing. This is often due to genetic mutations in the cancer cells that make them resistant to otherwise effective therapy. Also, there are inherent limitations in the drugs used to treat breast cancer. For example, some problems with chemotherapy include toxicity, the development of tumors that are resistant to chemotherapy, and the ability of chemotherapy to kill only rapidly dividing cells. A critical genetic defect in breast cancer is found in the p53 tumor suppressor gene, which makes p53 non-functional. Normally, p53 sensitizes the tumor cell to chemotherapy, which will induce programmed cell death (apoptosis). Our efforts are focused on new approaches to induce apoptosis in breast cancer cells, even if the cells lack functional p53 or are resistant to chemotherapy.

 Tumor necrosis factor (TNF), which regulates inflammatory responses and combats tumor growth, can induce cell death in tumor cells regardless of their p53 status and resistance to chemotherapy. TNF family members, however, also activate pathways in breast cancer cells that protect the cell from the cytotoxic action of the TNF. Recently, we have observed that a compound called PG490 that contains triptolide, a chemical derived from a traditional Chinese herb will (i) induce apoptosis in breast cancer cells, (ii) enhance chemotherapy-induced cytotoxicity, and (iii) induce apoptosis in multidrug-resistant breast cancer cells. PG490 also sensitizes breast cancer cells to apoptosis by members of the TNF family by blocking an inhibitor of apoptosis. Our project aims to investigate novel approaches to kill tumor cells both with PG490 alone and in combination with members of the TNF family. Most critical, we will study how to enhance cytotoxicity for breast tumors that have mutations in the p53 gene and where drug resistance is present. PG490 and members of the TNF family, unlike chemotherapy, also kill slowly dividing or quiescent cells. Most cells within a tumor at any one time are not dividing or are dividing slowly, so our approach has the advantage of targeting cells that evade the effects of chemotherapy and other common therapies aimed at dividing cells.

 These studies aim to provide a framework for future efforts that will examine the efficacy and safety of PG490 and members of the TNF family in animal breast cancer models. Our eventual goal is to pursue these studies in patients with breast cancer. As new technologies to detect breast cancer in younger women are developed, we must focus our attention on the therapeutic issues to ensure their long-term survival.
Risk-averse control of undiscounted transient Markov models
Creators: name: Cavus, Ozlem
Publisher: name: No Publisher Supplied
Year: 2012

description: The classical optimal control problems for discrete-time, transient Markov processes are infinite horizon, undiscounted expected total cost or reward models. Some examples of these models are optimal stopping problems and stochastic shortest or longest path problems, which may have applications in health-care, finance, and maintenance. However, such expected value models implicitly assume the decision maker is risk-neutral, so they may not be appropriate for several real-life problems.    In this study, we use Markov risk measures to formulate a risk-averse version of the optimal control problem for transient Markov processes with general state and compact control spaces. We derive risk-averse dynamic programming equations and show that they have a unique solution which is also the optimal value of the Markov control problem. Furthermore, it is shown that a randomized policy may be strictly better than deterministic policies, when risk measures are employed.    We suggest two algorithms, value iteration and policy iteration methods, for solving the dynamic programming equations and show their convergence. In general, each policy evaluation step of the policy iteration algorithm requires solving a system of nonsmooth equations. We use a version of nonsmooth Newton method to solve these equations and show its global convergence.    We further consider a risk-averse finite horizon Markov control problem under randomized policies and derive a value iteration method for its solution.    Finally, we work on asset selling, organ transplant, and credit card examples to illustrate the theory for infinite horizon problem, and present numerical results.
title: Zitrus-Schwarzfleckenkrankheit (CBS) - Phyllosticta citricarpa (= Guignardia citricarpa), Symptome und Verwechslungsmöglichkeiten
Creators: name: Douanla-Meli, Clovis
name: Unger, Jens-Georg
Publisher: name: Julius Kühn-Institut
publisherIdentifier: https://ror.org/022d5qt08
publisherIdentifierScheme: ROR
Year: 2014
Subjects: subject: Zitrus-Schwarzfleckenkrankheit (CBS)
subject: Phyllosticta citricarpa
subject: Guignardia citricarpa
subject: Symptome
subject: Verwechslungsmöglichkeiten
subject: Alternaria alternata
subject: Pseudomonas syringae pv. syringae
subject: Xanthomonas axonopodis pv. citri
subject: Septoria citri
subject: Nachweis

description: Informationsblatt des JKI
description: Zitruspflanzen und –früchte werden von verschiedenen Schadorganismen befallen. Einige Krankheiten führen einen Produktionsausfall herbei, während andere eher eine Wertminderung von Früchten verursachen. Die Schwarzfleckenkrankheit (CBS) verursacht Produktionsausfälle und mindert die Qualität der Früchte, und ist daher von allen Zitrusanbauern gefürchtet. Sie wird durch den pilzlichen Erreger Phyllosticta citricarpa (= Guignardia citricarpa) ausgelöst. CBS ist politisch wie wirtschaftlich aktuell von größerer Bedeutung für den Zitrushandel zwischen Anbauländern und der EU. Bisher kommt der Pilz in der EU nicht vor und unterliegt daher strengen Quarantäneregelungen. Um eine Einschleppung des Pilzes in die EU zu verhindern, müssen alle EU-Mitgliedsstaaten eine Kontrolle von Zitrusimporten auf CBS durchführen. Dabei erfolgt im ersten Schritt die Identifizierung der Symptome auf den Früchten. Diese sind jedoch nicht nur sehr variabel in ihrer Erscheinung, sondern je nach Entwicklungsphase sehr leicht mit Symptomen anderer Zitruskrankheiten zu verwechseln.
Factors contributing to disparities in early breast cancer treatment
Creators: name: Chandwani, Sheenu
Publisher: name: No Publisher Supplied
Year: 2012

description: Specific Aims:  This dissertation was conducted to examine the following specific aims among early breast cancer patients: 1) Racial differences in the use of pre-operative magnetic resonance imaging (MRI) and the role of pre-operative MRI on rates of re-operation and contralateral prophylactic mastectomy (CPM), and time to surgery; 2) Racial differences in elapsed time and sessions received during radiation therapy; and 3) Racial differences in chemotherapy dose modifications and role of neutropenia in this association.  Design, setting and subjects:  Subjects were selected from the Breast Cancer Treatment Disparity Study which is an ongoing cohort study of African American (AA) and white subjects residing in eastern New Jersey who were newly diagnosed with early breast cancer between 2005 and 2010.  Data were collected through a detailed review of medical records obtained from multiple health care providers of these participants.   Results:  A significantly higher use of pre-operative MRI among whites versus AAs (58.3% vs. 39.7%, p< 0.01) was seen in the first study.  Receipt of pre-operative MRI was associated with a non-significant lower rate of re-operation (RR= 0.76; 95% confidence interval [CI]: 0.54, 1.07), but a significantly higher rate of CPM (RR= 1.75; 95% CI: 1.04, 2.92) and a longer time to surgery (geometric mean= 40.5 days versus 27.6 days, p< 0.01).  The second study revealed no differences between AA and white women in elapsed time and sessions received during standard radiation therapy following lumpectomy (median elapsed time= 48 days, % subjects with >49 days elapsed time= 36%, and mean sessions= 33, for both racial groups).  In the third study, a significantly lower relative dose intensity (RDI) was delivered to AA subjects than white subjects (94.4% versus 100.0%, p= 0.005) during chemotherapy and the risk of >15% reduction in RDI was more than double (RR= 2.62; 95% CI: 1.40, 4.89) in AA women as compared to white women.  White blood cell counts at initiation of chemotherapy and in subsequent cycles were similar between the races and were unable to account for differences in dose intensity between the two groups.  Conclusion:  The rapid rise in use of pre-operative MRI is a concern as no benefit of its use was observed in this study.  We also conclude that once treatment is initiated AA women and white women were very similar in receipt of care delivered during radiation.  However, this did not hold true for chemotherapy.  AA women in comparison to white women were at more than two-fold risk of experiencing dose modifications during chemotherapy that was not explained by differences in their blood counts.
Dietary Indole Analogs for Breast Cancer Prevention
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Prevention is the best way of dealing with any disease, and this is particularly true of cancer, with all of its complexities and its often devastating course. Numerous studies suggest an effective role for fruits and vegetables in the prevention of human cancer, especially breast cancer. Such preventive effects are very likely to come from tumor inhibitors that occur naturally in food and plants. Dietary natural products are presumably safe, and thus are very attractive as the lead compounds for developing novel cancer preventive agents.

 Indole-3-carbinol (I3C), a dietary component found in cruciferous vegetables such as cabbage, broccoli, and Brussels sprouts, has a striking ability to prevent breast cancer in various laboratory models, and it is currently undergoing Phase I clinical trials for breast cancer prevention in humans. However, I3C itself is far from an ideal breast cancer preventive agent. One serious drawback is that the compound itself is not active against cancer but must be acted on by gastric acid in the stomach to produce the active forms, and it is not known which of its many digestion products is the most important for cancer prevention. Furthermore, the cancer preventive effect may vary considerably between individuals, and at different times in the same individual, because variation in gastric contents could substantially affect the formation of the active forms. Clearly, there is room for improvement.

 This research project aims to develop a safe, effective reliable breast cancer preventive agent based on I3C and four of its known active forms. We have found some important structural similarities in the four active forms by using computer modeling and analysis, and we plan to use one active form as the framework and modify it with carefully designed changes. Our goal is an I3C derivative that can be taken orally, retains the ability to inhibit activities associated with cancer onset, and has improved stability, increased clinical effectiveness, consistent results, and minimal toxicity and side effects. This novel breast cancer prevention candidate will be unique because it is a derivative of a dietary natural product whose history of consumption by humans for centuries indicates it is likely to be safe for long-term use.

 Our multidisciplinary approach combines lead-based compound design, medicinal chemistry, computer modeling, cell culture biological screening, and tumor biology. The systematic development of compounds is coupled with basic research into mechanisms of action and feedback of the findings to guide design and discovery of improved compounds. Achievement of our goals could have a significant impact on reducing the human and economic costs of breast cancer in California.
Annulariidae
Creators: name: Leal, José H.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Littorinimorpha
Annulariidae

description: Family Annulariidae
Abbottella aenea Watters, 2010; two paratypes.
Abbottella tenebrosa Watters, 2013; sixteen paratypes.
Adamsiella crenulata martinensis Coomans, 1967 (Figure 18); four paratypes.
Articulipoma rhodei Watters, 2012; two paratypes.
Chondropoma pictum yumeriense Torre & Bartsch, 1938 (Figure 19); two paratypes.
Chondropoma turnerae Clench, 1950 (Figure 20); nine paratypes.
Chondropoma vanattae polychroma Watters, 2012; one paratype.
Clydonopoma titanum Watters & Larson, 2017; one paratype.
Leiabbottella galaxius Watters, 2010; two paratypes.
Licina bartschi Watters, 2012; one paratype.
Opisthosiphon thesaurus Watters, 2019; one paratype.
Parachondria gettlemani Watters, 2012; one paratype.
Parachondria heatheraikenae Watters, 2016; one paratype.
Rolleia oberi Watters & Duffy, 2010; two paratypes.
Rolleia simonaikeni Watters, Smith, & Sneddon, 2020; one paratype.
Weilandipoma auduboni Watters, Grego, & Šteffek, 2013; one paratype.
Weinlandipoma macayaense Watters, Grego, & Šteffek, 2013; one paratype.
description: Published as part of Leal, José H., 2021, Type specimens in the molluscan collection of the Bailey-Matthews National Shell Museum, Florida, USA, pp. 1-40 in Zootaxa 4951 (1) on page 4, DOI: 10.11646/zootaxa.4951.1.1, http://zenodo.org/record/4655535
U.S. artists imagining Mexico, Central America and Cuba, 1875-1910
Creators: name: Bramham, Diana
Publisher: name: No Publisher Supplied
Year: 2012

description: This dissertation investigates representations of Mexico, Central America and Cuba produced by U.S. artists from 1875 to 1910. As the United States strengthened its political and economic ties with its closest southern neighbors, a desire for visual knowledge of the people and places just south of the border grew. Paintings, photographs, films and illustrations by artists such as Eadweard Muybridge, Winslow Homer and William Henry Jackson introduced an unfamiliar U.S. public to the ―Other‖ America. While some of these artists constructed a vision of Mexico, Central America and Cuba as picturesque places mired in the past and ripe for U.S. expansionist efforts, others portrayed these lands as sites of mounting tension that suggest anxiety surrounding the increasingly intimate relationship between the North and South. A careful analysis of these images, the contemporary responses to them and the socio-historical context in which they were created reveals another veiled subject—the United States and its struggle to define its own identity at a watershed moment in its history. A study of the visual manifestation of the United States' relationship with Mexico, Central America and Cuba is at the forefront of recent scholarship that seeks to extend the scope of American art beyond geographic borders, embracing a more global, non-Euro-centrist perspective.
Hesperocythere klasteroides Hart & Hart 1967, sp. nov.
Creators: name: Williams, Bronwyn W.
name: Weaver, Patricia G.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Hesperocythere
Hesperocythere klasteroides

description: * Hesperocythere klasteroides Hart & Hart, 1967
1967b Hesperocythere klasteroides sp. nov. —Hart & Hart: 8, 29–30, 31, 48, 49, Figs. 83–85 (A, D, H, K, R, T).
1974 Hesperocythere klasteroides Hart and Hart, 1967.—Hart & Hart: 145, 151, 152, 153, 216, 237, Pl. XL Figs. 10–11, Pl. LXI (C, D, H, K, R, T).
1975 Hesperocythere klasteroides Hart & Hart, 1967.—Hart & Hart: 56, 57 (C, D, H).
2014a Hesperocythere klasteroides Hart & Hart, 1967.—Mestre, Monrós & Mesquita-Joanes: 950 (C).
description: Published as part of Williams, Bronwyn W. & Weaver, Patricia G., 2018, A historical review of the taxonomy and classification of Entocytheridae (Crustacea: Ostracoda: Podocopida), pp. 1-129 in Zootaxa 4448 (1) on page 102, DOI: 10.11646/zootaxa.4448.1.1, http://zenodo.org/record/1444492
title: Congenital Problems
Creators: name: Bryant, Mikey
Publisher: name: eScholarship@UMassChan
Year: 2022

description: This presentation is part of the PEER Liberia Pediatrics Lecture Series. It provides an overview for physicians of the diagnosis and treatment of congenital diseases and abnormalities, including Down Syndrome, Klinefelter’s Syndrome, Patau Syndrome (Trisomy 13), Turner Syndrome, congenital heart problems, and Trisomy 18 (Edward's Syndrome).
Euplectrus liparidis Ferriere
Creators: name: Yefremova, Zoya A.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy

description: 40. Euplectrus liparidis Ferrière
Material examined 1 ♀, Israel, Herzliyya hill, sweeping, 2.iv.2010 (A. Freidberg), 1 ♀, Botanical garden, Tel Aviv, M.T., ii.2010 (Z. Yefremova, V. Kravchenko); 2 ♀, Qetura, elv. 126 m, YPT, 3-8 May 2013, (Z. Yefremova); 1 ♀, Yeruham (Central Negev), sweeping, 21.i.2015 (Z. Yefremova, V. Kravchenko).
Hosts. Ectoparasitoid of Agrapha agnate Staudinger, Leucania loreyi (Duponchel), Plusia agnata Staudinger (Lepidoptera: Noctuidae) (Zhu & Huang 2003; Yefremova et al. 2007).
Distribution. Israel *; Palearctic (Zhu & Huang 2003; Yefremova et al. 2007).
description: Published as part of Yefremova, Zoya A., 2015, An annotated checklist of the Eulophidae (excl. Tetrastichinae) (Hymenoptera: Chalcidoidea) of Israel, pp. 1-36 in Zootaxa 3957 (1) on page 11, DOI: 10.11646/zootaxa.3957.1.1, http://zenodo.org/record/288546
Development and characterization of lipid based nanosystems of quercetin for topical delivery
Creators: name: Bose, Sonali
Publisher: name: No Publisher Supplied
Year: 2012

description: The presence of large amounts of reactive oxygen species (ROS) leads to oxidative stress that can damage cell membranes, lead to DNA breakage and inactivation of free radical scavenger enzymes, eventually resulting in skin damage. The natural flavonoid quercetin (3, 3’, 4’, 5,7-pentahydroxyflavone) has been shown to have the highest anti-radical activity, along with the ability to act as a scavenger of free radicals and an inhibitor of lipid peroxidation. In this research work, lipid based nanosystems of quercetin have been developed using lipids and surfactants considered acceptable in topical formulations and evaluated for topical delivery of quercetin. Systematic screening of the formulation and process parameters led to the development of a physically stable solid lipid (glyceryl dibehenate) based nanosystem using a probe ultrasonication method. Further optimization of the formulation included substitution of a part of the solid lipid (glyceryl dibehenate) with a liquid lipid (oleic acid) to generate nanostructured lipid carriers (NLC). High pressure homogenization, a method widely used in the pharmaceutical industry to generate nanoparticles, was also evaluated as a manufacturing process for these lipid based nanosystems. Transmission electron microscopy (TEM) studies showed spherical particles in the nanometer range for all the systems. XRD scans indicated the onset of a partial transformation of glyceryl behenate from the metastable β’ to the more stable βi form for all formulations. In vitro release studies showed a biphasic release profile, characterized by an initial burst release followed by a more controlled release pattern. Skin permeation studies using full thickness human skin showed a statistically significant increase in the amount of quercetin retained in the skin from the NLC formulation compared to non-nanosized control formulations, with and without oleic acid. This demonstrated the potential of these lipid based nanosystems to act as suitable agents for the topical delivery of quercetin. Both SLN and NLC formulations were also found to have no genotoxic or cytotoxic effects at the concentrations evaluated.
Managing Forensic Recovery in the Cloud
Creators: name: Weir, George R. S.
name: Aßmuth, Andreas
name: Jäger, Nicholas
Publisher: name: arXiv
Year: 2024
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Computer and information sciences

description: As organisations move away from locally hosted computer services toward Cloud platforms, there is a corresponding need to ensure the forensic integrity of such instances. The primary reasons for concern are (i) the locus of responsibility, and (ii) the associated risk of legal sanction and financial penalty. Building upon previously proposed techniques for intrusion monitoring, we highlight the multi-level interpretation problem, propose enhanced monitoring of Cloud-based systems at diverse operational and data storage level as a basis for review of historical change across the hosted system and afford scope to identify any data impact from hostile action or 'friendly fire'.
description: 6 pages
Rissoinidae
Creators: name: Leal, José H.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Littorinimorpha
Rissoinidae

description: Family Rissoinidae
Rissoina delicatissima Raines, 2002 (Figure 21); two paratypes.
Rissoina harryleei Rolán & Fernández-Garcés, 2009; one paratype.
description: Published as part of Leal, José H., 2021, Type specimens in the molluscan collection of the Bailey-Matthews National Shell Museum, Florida, USA, pp. 1-40 in Zootaxa 4951 (1) on page 5, DOI: 10.11646/zootaxa.4951.1.1, http://zenodo.org/record/4655535
Heregulin-specific Diphtheria Toxin as a Cancer Therapy
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Normally, the growth of human breast cells is closely controlled by steroid hormones, such as estrogen, and other growth-promoting proteins, such as heregulin. Cancerous cells that overproduce the HER2 and HER4 oncogene proteins have progressed to a diseased state where they are no longer responsive to anti-estrogen treatment (e.g., tamoxifen). Often, the unwanted growth of breast cancer cells is promoted by heregulin, a protein that interacts with and activates the HER2 and HER4 proteins on the cell surface. In some instances, the breast cancer cells themselves produce heregulin. Thus, neutralizing the growth-promoting activities of heregulin is one strategy for breast cancer therapy. Our goal is to design a toxin protein that will kill cells carrying heregulin.

 Diphtheria toxin is known to kill certain types of cells carrying a specific receptor protein on their surface. Diphtheria toxin enters the cell via the receptor and arrests protein synthesis to cause cell death. Importantly, the normal diphtheria toxin receptor has strong similarity to the heregulin growth factors involved in stimulating breast cancer cells. Thus, diphtheria toxin will serve as the starting material in our design of a new toxin capable of recognizing and killing only cells that produce heregulin. We anticipate that this new toxin variant may be effective in several approaches to limit the overall growth of breast cancer. First, the targeted delivery of the toxin's killing activity to heregulin-producing cells will reduce circulating levels of heregulin that can cause the growth of breast cancer cells. Second, breast cancer cells that produce heregulin will be selectively killed. Third, binding of the toxin protein to heregulin will prevent it from activating the HER2 and HER4 proteins on cancerous cells.

 Our approach is to custom design diphtheria toxin by using a three-dimensional picture produced by X-ray crystallography. This analysis shows in detail how atoms of the diphtheria toxin fit together with atoms of its normal cell surface receptor - like pieces of a jigsaw puzzle. This allows us to identify key atoms dictating this interaction. Then, we will construct variant diphtheria toxin molecules using biology techniques with the aim of targeting the toxin to heregulin-bearing cells. This appears feasible and will require only small changes on the toxin. The biologic activity of this designed toxin will be determined by using breast cancer cell lines that express heregulin.

 Although only about 30% of patients appear to express the HER2 oncogene, these patients experience the least favorable clinical outlook. Our approach may provide an alternative to the current clinical development of antibody therapy to HER2-containing breast cancers.
Hesperocythere tallanalla Hart & Hart 1967, sp. nov.
Creators: name: Williams, Bronwyn W.
name: Weaver, Patricia G.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Hesperocythere
Hesperocythere tallanalla

description: Hesperocythere tallanalla Hart & Hart, 1967
1967b Hesperocythere tallanalla sp. nov. —Hart & Hart: 8, 28, 30, 48, 49, Figs. 86–88 (A, D, H, K, R, T).
1974 Hesperocythere tallanalla Hart and Hart, 1967.—Hart & Hart: 145, 152, 216, 237, Pl. XL Figs. 12–14, Pl. LXI (C, D, H, K, R, T).
1975 Hesperocythere tallanalla Hart & Hart, 1967.—Hart & Hart: 57 (C, D, H).
2014a Hesperocythere tallanalla Hart & Hart, 1967.—Mestre, Monrós & Mesquita-Joanes: 950 (C).
description: Published as part of Williams, Bronwyn W. & Weaver, Patricia G., 2018, A historical review of the taxonomy and classification of Entocytheridae (Crustacea: Ostracoda: Podocopida), pp. 1-129 in Zootaxa 4448 (1) on page 102, DOI: 10.11646/zootaxa.4448.1.1, http://zenodo.org/record/1444492
Disruption of angiogenesis by methyl tert-butyl ether (MTBE) is mediated by a dysregulation of the vascular endothelial growth factor (VEGF) pathway
Creators: name: Bonventre, Josephine Ann
Publisher: name: No Publisher Supplied
Year: 2012

description: Vascular endothelial growth factor (VEGF) is an essential mitogenic factor required for normal angiogenesis. In development, the primary inducer of this protein is hypoxia via hypoxia inducible factors (HIFs). Methyl tert-butyl ether (MTBE) was hypothesized to disrupt angiogenesis by altering the HIF-VEGF pathway. Exposure of zebrafish embryos to MTBE caused vascular lesions, specifically pooled blood in the common cardinal vein (CCV), cranial hemorrhages, and abnormal intersegmental vessels (ISV). These lesions occurred throughout development and were preceded by a critical period between 6-somites and Prim-5 stages during which there was a significant decrease in mRNA transcript levels of vegf-a, vegf-c and vegf receptor 2 (vegfr2). Lesions other than those associated with the vasculature were not observed. Embryonic exposure to the two primary metabolites, tert-butyl alcohol and formaldehyde, did not induce vascular lesions, indicating the parent chemical was responsible for the anti-angiogenesis. When embryos were exposed to two structurally related chemicals, ethyl tert-butyl ether  iii  (ETBE) or tert-amyl methyl ether (TAME), some vascular lesions were observed, but zebrafish also exhibited lesions in the heart, whole body edema, and craniofacial abnormalities. Unlike MTBE, ETBE, and TAME exposure did not significantly alter vegf expression. Of the 3 structurally similar ethers, MTBE appears unique in its ability to target developing endothelial cells. An analysis of the global gene expression changes in zebrafish exposed to MTBE during the critical period identified the cardiovascular system was among the most altered pathways affected by MTBE toxicity. Finally, manipulation of the HIF-VEGF pathway to rescue the specific MTBE-induced vascular lesions, via an over-expression of vegf-a and inhibition of HIF degradation, convincingly demonstrated that MTBE toxicity is mediated by the down regulation of VEGF at a critical time during cardiovascular development. Understanding the underlying mechanisms of angiogenesis is important to developing new therapies used to quell solid tumor growth, enhance wound repair, and reduce diabetes induced vascular damage, among others. Chemicals with anti-angiogenic properties, such as MTBE, can be used to advance the science of angiogenesis in both a disease state and during development.
Chromatin Regulation of Breast Cancer Cell Senescence
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Normal mammalian cells can undergo only a fixed number of cell divisions. This intrinsic end to cell’s capacity to divide is termed cellular senescence. Tumor cells have mechanisms to evade these limitations, which contributes to cancer’s growth potential. Furthermore, the largest risk factor for the development of most types of cancer, including breast cancer, is age. This is thought to be due to the continuous accumulation of damaging mutations in critical genes. These mutations are rare random events that represent changes in the genetic instructions in a cell's chromosomes, and they can disrupt a cell's ability to undergo senescence. It is therefore of great interest to cancer researchers to understand the various ways that cells naturally try to protect themselves from mutational damage, and also to better understand the many uncharacterized aspects of cellular senescence. Every cell's chromosomes contain not only the genetic instructions (the DNA), but also proteins bundled with the DNA to form chromatin. Recent discoveries in yeast have shown that some chromatin proteins protect chromosomes from damage that accumulates as cells age.

 This project seeks to extend these recent discoveries, explore how damage occurs to chromosomes in human breast cells during cellular aging, and how chromatin proteins might act to delay this process. We propose to test the relationship between chromatin proteins and cellular lifespan. To do this, we will determine the effects of disrupting the function of a protein complex called chromatin assembly factor (CAF)-I, which is responsible for forming the basic structural unit of chromosomes, the ‘nucleosome’. Our project involves both the introduction of CAF-I mutant subunits into breast cancer cells lines and the overexpression of normal CAF-I in other experiments. We will examine the effects of CAF-I on (i) chromosomal structure, (ii) the ability of cells to repair DNA damage induced by UV radiation, and (iii) cellular senescence measurements. Based on the previous data, we expect that these studies will clarify the relationship of CAF-I in regulating the lifespan and growth control of breast cancer cells.

 Although chromosomal structure has been implicated in the regulation of cellular aging, and aging is correlated with increased cancer risk, very little direct experimentation has been done to associate these three topics with regard to human breast cell biology. Our results may lead to new approaches for the prevention or treatment of breast cancer that target specific chromatin proteins in order to block the ability of breast cells to proliferate.
Euplectrus phthorimaeae Ferriere
Creators: name: Yefremova, Zoya A.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy

description: 41. Euplectrus phthorimaeae Ferrière
Material examined. 1 ♀, Israel, Har Meron, 32°59’N; 34°24’E, M.T., 20.vi.2007 (T. Levanony); 1 ♀, Herzliyya,
hill, 32°11’N; 34°49’E, sweeping, 14.x.2008 (A. Freidberg).
Hosts. Ectoparasitoid of Phthorimaea terrella Walker (Gelechiidae) (Bouček & Askew 1968). Distribution. Israel (Bouček & Askew 1968); Cyprus (Ferrière 1941).
42. Euplectrus scapus Yefremova
Material examined: 1 ♂, Israel, Mineral Beach, sweeping, 24.ix.1998 (A. Freidberg). Hosts. Unknown.
Distribution. Israel *; Yemen, UAE (Yefremova 2007).
description: Published as part of Yefremova, Zoya A., 2015, An annotated checklist of the Eulophidae (excl. Tetrastichinae) (Hymenoptera: Chalcidoidea) of Israel, pp. 1-36 in Zootaxa 3957 (1) on page 12, DOI: 10.11646/zootaxa.3957.1.1, http://zenodo.org/record/288546
The relationship of skin tone to physical and mental health outcomes in South Asian Americans
Creators: name: Bhagwat, Ranjit
Publisher: name: No Publisher Supplied
Year: 2012

description: Since 1990, the South Asian population in America has exhibited massive growth, as large numbers of immigrants from India, Pakistan, and other South Asian countries have arrived in the United States. Yet limited empirical psychological research has been conducted assessing race-related stressors in this population. Skin tone (skin color) has been linked frequently with physical and mental health outcomes in other American ethnic minority populations, such that dark skin tone typically correlates with poor outcomes. The present study demonstrated, in a relatively large sample of South Asian Americans, that darkness of skin tone negatively predicted self-esteem and self-rated physical health. Contrary to expectations, dark skin tone positively predicted general mental health. The study also investigates the mediation role of perceived discrimination and body image disturbance in these relationships, as well as the moderating roles of gender, socioeconomic status, and ethnic identification. The relationship of dark skin tone to low self-esteem, but not low self-rated physical health or high general mental health, was mediated via increased body image disturbance. Ethnic identification moderated the positive association between dark skin tone and general mental health, such that this association was strong at low levels of ethnic identification and reversed for individuals of high ethnic identification. Neither gender nor ethnic identification moderated the negative associations between dark skin tone and low self-rated physical health or low self-esteem. Implications and recommendations are discussed.
Hesperocythere xiphoides Hart & Hart 1967, sp. nov.
Creators: name: Williams, Bronwyn W.
name: Weaver, Patricia G.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Hesperocythere
Hesperocythere xiphoides

description: Hesperocythere xiphoides Hart & Hart, 1967
1967b Hesperocythere xiphoides sp. nov. —Hart & Hart: 8, 27, 29, 30, 31, 48, 49, Figs. 89–91 (A, D, K, R, T).
1974 Hesperocythere xiphoides Hart and Hart, 1967.—Hart & Hart: 145, 152–153, 216, 237, Pl. XL Figs. 15–17, Pl. LXI (C, D, H, K, R, T).
1975 Hesperocythere xiphoides Hart & Hart, 1967.—Hart & Hart: 57 (C, D, H).
2014a Hesperocythere xiphoides Hart & Hart, 1967.—Mestre, Monrós & Mesquita-Joanes: 950 (C).
description: Published as part of Williams, Bronwyn W. & Weaver, Patricia G., 2018, A historical review of the taxonomy and classification of Entocytheridae (Crustacea: Ostracoda: Podocopida), pp. 1-129 in Zootaxa 4448 (1) on page 102, DOI: 10.11646/zootaxa.4448.1.1, http://zenodo.org/record/1444492
Personidae
Creators: name: Leal, José H.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Littorinimorpha
Personidae

description: Family Personidae
Distorsio jenniernestae Emerson & Piech, 1992; one paratype.
description: Published as part of Leal, José H., 2021, Type specimens in the molluscan collection of the Bailey-Matthews National Shell Museum, Florida, USA, pp. 1-40 in Zootaxa 4951 (1) on page 5, DOI: 10.11646/zootaxa.4951.1.1, http://zenodo.org/record/4655535
Hemiptarsenus autonomus Mercet
Creators: name: Yefremova, Zoya A.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Eulophidae
Hemiptarsenus
Hemiptarsenus autonomus

description: 43. Hemiptarsenus autonomus (Mercet)
Material examined. 1 ♂, Israel, Har Carmel, Nesher road, sweeping, 380m, 32°45’N; 35°02’E, 21.ix.2010 (A. Freidberg).
Hosts. Ectoparasitoid of Gracillariidae (Lepidoptera) (Trjapitzin 1978). Distribution. Israel *; Palearctic (Trjapitzin 1978; Boyadzhiev 1997; Yefremova 2002)..
description: Published as part of Yefremova, Zoya A., 2015, An annotated checklist of the Eulophidae (excl. Tetrastichinae) (Hymenoptera: Chalcidoidea) of Israel, pp. 1-36 in Zootaxa 3957 (1) on page 12, DOI: 10.11646/zootaxa.3957.1.1, http://zenodo.org/record/288546
Novel Breast Cancer Epithelial Cell Metalloproteinase
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Breast cancer occurs as a result of alterations in the mechanisms that control normal cell behavior. Cancer and normal cells differ in two fundamental ways: (i) cancer cells grow inappropriately and (ii) cancer cells generally lose their ability to serve the normal functions. These two differences are closely associated with breast epithelial cells, the cell type from which more than 90% of the breast cancer arise. In addition, cancer cells may migrate (metastasize) from the breast and invade the lymph nodes and other foreign sites (e.g., lung or bone). Our research will provide critical insights into how breast epithelial cells lose their proper control of growth and function and, in particular, how they acquire the ability to become invasive to initiate metastasis.

 We will use a breast cell culture system developed previously to carry out these studies. Using this cell system, we have already shown that a specific intracellular protein (Id-1) is critical for coordinating the growth and function of the cells. When the Id-1 level is elevated inappropriately, it causes the cells to lose their normal functions and become invasive. Further, we have found that cells with an elevated level of Id-1 protein will secrete an extracellular enzyme (a metalloproteinase), which can potentially destroy the extracellular matrix surrounding the breast epithelial cells. Therefore, this enzyme may be a crucial factor in making the breast epithelial cells abnormally invasive in cell culture, and it may also contribute to the invasive potential of some aggressive breast tumors. We will study this metalloproteinase enzyme by isolating it using two different approaches. After isolation, we will have both the protein sequence and the DNA probes, which will then allow us to answer several fundamental questions. For example, how is the novel metalloproteinase related to other described enzymes of different size and distribution? Where is this enzyme produced in the breast and other organs in the body? Is this enzyme overproduced in the breast of breast cancer patients? Our eventual objective is to determine whether this enzyme can trigger metastasis in breast cancer cells.
Caecidae
Creators: name: Leal, José H.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Littorinimorpha
Caecidae

description: Family Caecidae
Caecum metamorphosicum Lima, Santos, & Absalão, 2013; five paratypes.
description: Published as part of Leal, José H., 2021, Type specimens in the molluscan collection of the Bailey-Matthews National Shell Museum, Florida, USA, pp. 1-40 in Zootaxa 4951 (1) on page 5, DOI: 10.11646/zootaxa.4951.1.1, http://zenodo.org/record/4655535
Eulimidae
Creators: name: Leal, José H.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Littorinimorpha
Eulimidae

description: Family Eulimidae
Eulima clarimaculosa Raines, 2003 (Figure 22); two paratypes.
Sticteulima plenicolora Raines, 2003 (Figure 23); two paratypes.
Subniso osorioae Raines, 2003 (Figure 24); two paratypes.
description: Published as part of Leal, José H., 2021, Type specimens in the molluscan collection of the Bailey-Matthews National Shell Museum, Florida, USA, pp. 1-40 in Zootaxa 4951 (1) on page 5, DOI: 10.11646/zootaxa.4951.1.1, http://zenodo.org/record/4655535
Hipponicidae Troschel 1861
Creators: name: Leal, José H.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Littorinimorpha
Hipponicidae

description: Family Hipponicidae
Cheilea americana Rolán, Redfern, & Fernández-Garcés, 2014 (Figure 25); holotype + two paratypes.
description: Published as part of Leal, José H., 2021, Type specimens in the molluscan collection of the Bailey-Matthews National Shell Museum, Florida, USA, pp. 1-40 in Zootaxa 4951 (1) on page 5, DOI: 10.11646/zootaxa.4951.1.1, http://zenodo.org/record/4655535