cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
ω‐Imidazolyl‐alkyl derivatives as new preclinical drug candidates for treating non‐alcoholic steatohepatitis
Creators: name: Diesinger, Torsten
name: Lautwein, Alfred
name: Buko, Vyacheslav
name: Belonovskaya, Elena
name: Lukivskaya, Oksana
name: Naruta, Elena
name: Kirko, Siarhei
name: Andreev, Viktor
name: Dvorsky, Radovan
name: Buckert, Dominik
name: Bergler, Sebastian
name: Renz, Christian
name: Müller‐Enoch, Dieter
name: Wirth, Thomas
name: Haehner, Thomas
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: non‐alcoholic steatohepatitis
subject: DDC 610 / Medicine & health
subject: Cytochrome P-450 CYP2E1
subject: Non-alcoholic Fatty Liver Disease
subject: Reactive Oxygen Species
subject: Cytochrom P-450

description: Cytochrome P450 2E1 (CYP2E1)-associated reactive oxygen species production plays an important role in the development and progression of inflammatory liver diseases such as alcoholic steatohepatitis. We developed two new inhibitors for this isoenzyme, namely 12-imidazolyl-1-dodecanol (I-ol) and 1-imidazolyldodecane (I-an), and aimed to test their effects on non-alcoholic steatohepatitis (NASH). The fat-rich and CYP2E1 inducing Lieber-DeCarli diet was administered over 16 weeks of the experimental period to induce the disease in a rat model, and the experimental substances were administered simultaneously over the last four weeks. The high-fat diet (HFD) pathologically altered the balance of reactive oxygen species and raised the activities of the liver enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (AP) and γ-glutamyl-transferase (γ-GT); lowered the level of adiponectine and raised the one of tumor necrosis factor (TNF)-α; increased the hepatic triglyceride and phospholipid content and diminished the serum HDL cholesterol concentration. Together with the histological findings, we concluded that the diet led to the development of NASH. I-ol and, to a lesser extent, I-an shifted the pathological values toward the normal range, despite the continued administration of the noxious agent (HFD). The hepatoprotective drug ursodeoxycholic acid (UDCA), which is used off-label in clinical practice, showed a lower effectiveness overall. I-ol, in particular, showed extremely good tolerability during the acute toxicity study in rats. Therefore, cytochrome P450 2E1 may be considered a suitable drug target, with I-ol and I-an being promising drug candidates for the treatment of NASH.
Supplementary Material: additional details of the methods used in the paper and Figure S1 (showing multiple estimated transitions in extinction risk throughout the phylogeny). from Chemical antipredator defence is linked to higher extinction risk
Creators: name: Arbuckle, Kevin
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 60801 Animal Behaviour

description: Many attributes of species may be linked to contemporary extinction risk, though some such traits remain untested despite suggestions that they may be important. Here, I test whether a trait associated with higher background extinction rates, chemical antipredator defence, is also associated with current extinction risk, using amphibians as a model system—a group facing global population declines. I find that chemically defended species are approximately 60% more likely to be threatened than species without chemical defence, although the severity of the contemporary extinction risk may not relate to chemical defence. The results confirm that background and contemporary extinction rates can be predicted from the same traits, at least in certain cases. This suggests that associations between extinction risk and phenotypic traits can be temporally stable over long periods. The results also provide novel insights into the relevance of antipredator defences for species subject to conservation concerns.
Lanercost Priory excavations in 1994.
Creators: name: Whitworth, Alan M
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 98, 133-144
description: Four infant burials (unrecorded so thought likely to be unbaptised), pottery, clay pipes, lead, and masons' marks are noted. There are authored notes on
Supplementary material from “Unraveling Darwin's entangled bank: architecture and robustness of mutualistic networks with multiple interaction types”
Creators: name: Dáttilo, Wesley
name: Lara-Rodríguez, Nubia
name: Jordano, Pedro
name: Guimarães, Paulo R.
name: Thompson, John N.
name: Marquis, Robert J.
name: Medeiros, Lucas P.
name: Ortiz-Pulido, Raul
name: Marcos-García, Maria A.
name: Rico-Gray, Victor
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 60801 Animal Behaviour

description: Multi-interaction network involving different types of mutualism (animal pollination, seed-dispersal by frugivorous birds, and anti-herbivore defense by protective ants) sampled in a coastal tropical environment in Mexico.
Stainmore, Cumbria: archaeological investigation on the A66 Stainmore to Banks Gate road improvement scheme.
Creators: name: Drury, Denise
name: Hair, Nick J
name: Howard-Davis, Christine L E
name: Krupa, M
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 98, 119-132
description: Reports survey, excavation and watching brief work undertaken between 1992 and 1994 by the Lancaster University Archaeological Unit on a six kilometre stretch of road. The course of the road approximates the Roman route over the Pennines between Bowes (Co Durham) and Brough (Cumbria). Survey revealed sites pertaining to communications, land division, agrarian activity, mineral extraction and settlement. Excavation was undertaken at Augill Bridge (a possible medieval deer park boundary ditch and bank), Cooper House (where eight areas were opened up across an east--west stone-revetted terrace thought to be the line of the Roman road), Craco Farm's post-medieval house and farm buildings. The watching brief during topsoil stripping did not reveal any new sites.
Survey and excavations of a cropmark enclosure at Edderside, Cumbria 1989-1990.
Creators: name: Bewley, Robert H
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 98, 107-118
description: Small-scale excavation revealed that though the cropmark site did not conform to the usual RB pattern, occupation probably ranged between the second and fourth centuries AD. The shape may be the result of re-occupation of a prehistoric site. Includes:
Excavations at Bowness-on-Solway, 1973.
Creators: name: Potter, Timothy W
Publisher: name: Archaeology Data Service
Year: 2008

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 75, 29-57
description: NY 221626. Limited excavation under bad weather conditions suggested that Hadrianic turf and clay defences and timber buildings were succceded by a stone fort of ?late Hadrianic date, with some major rebuilding in ?early 3rd-century. Artefacts are catalogued and medieval documents described.
Losing Passion and Injured Self-Image: Stress of Conscience among Nurses Caring for Older People with Delirium in Hospital in Australia
Creators: name: Jokwiro, Yangama
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 420502
subject: Aged care nursing
classificationCode: 520104
subject: Industrial and organisational psychology (incl. human factors)
classificationCode: 520503
subject: Personality and individual differences

description: Submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to La Trobe Rural Health School, La Trobe University, Victoria, Australia.
Supplementary details about the experimental methods from Bridging the gap: parkour athletes provide new insights into locomotion energetics of arboreal apes
Creators: name: Halsey, Lewis G.
name: Coward, Samuel R. L.
name: Thorpe, Susannah K. S.
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 110601 Biomechanics
subject: FOS: Health sciences
subject: 60801 Animal Behaviour

description: Detailed materials and methods, and explanation and regression figures of re-analysis based on digitisation of Figure 1A in Hanna et al. (2008)
Substitution of perioperative albumin deficiency disorders (SuperAdd) in adults undergoing vascular, abdominal, trauma, or orthopedic surgery: protocol for a randomized controlled trial
Creators: name: Schaller, Stefan J.
name: Fuest, Kristina
name: Ulm, Bernhard
name: Schmid, Sebastian
name: Bubb, Catherina
name: Von Eisenhart-Rothe, Rüdiger
name: Friess, Helmut
name: Kirchhoff, Chlodwig
name: Stadlbauer, Thomas
name: Luppa, Peter
name: Blobner, Manfred
name: Jungwirth, Bettina
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Hypalbuminemia
subject: IMMATURE PLATELETS
subject: REPLACEMENT
subject: RECOVERY
subject: DDC 610 / Medicine & health
subject: Serum Albumin
subject: Perioperative Care
subject: Postoperative Care
subject: Postoperative Complications
subject: Acute Kidney Injury
subject: Risk
subject: Serumalbumine
subject: Postoperative Phase
subject: Rehabilitation

description: Abstract Background Hypalbuminemia is associated with numerous postoperative complications, so a perioperative albumin substitution is often considered. The objective of SuperAdd is to investigate whether substitution of human albumin, aiming to maintain a serum concentration > 30 g/l, can reduce postoperative complications in normovolemic surgical patients in comparison with standard care. Methods/design SuperAdd is a single-center, prospective, randomized, outcome-assessor blinded, patient blinded controlled trial. The primary outcome is the frequency of postoperative complications identified using the Postoperative Morbidity Survey graded ≥ 2 according to the Clavien-Dindo Score. Adult patients at risk to develop hypalbuminemia, i.e., ASA III or IV or high-risk surgery, are recruited after written informed consent was obtained. The albumin concentration is assessed before the induction of anesthesia and every 3 h until admission to the postanesthesia care unit. If albumin concentrations drop below 30 g/l, patients are randomly allocated to the control or the treatment group. The study intervention is a goal-directed human albumin substitution aimed at a concentration > 30 g/l during surgery and postanesthesia care unit stay. The patients in the control group are treated according to standard clinical care. Postoperative visits are to be performed on days 1, 3, 5, 8, and 15, as well as by telephone 6 months after surgery. Discussion SuperAdd is the first clinical trial in a surgical population investigating the effect of a goal-directed albumin substitution aiming at a serum level > 30 g/l. The nonrestrictive selection of patients guarantees that the patients without albumin screening will most likely not develop hypalbuminemia, thus ensuring generalizability of the study results. Trial registration EudraCT 2016-001313-24. Registered on 5 September 2016. Clinical Trials NCT03167645. Registered on 18 October 2016 and has the Universal Trial Number (UTN) U1111-1181-2625.
EFFECTIVE WAYS TO LEARN ENGLISH
Creators: name: Bozorova, Sevara
name: Saidov, Ravshan
Publisher: name: Zenodo
Year: 2024

description: Learning English can open doors to countless opportunities, from enhancing communication skills to unlocking access to a global community. Whether you're a beginner embarking on your language learning journey or seeking to refine your existing skills, the quest to master English is both rewarding and empowering. In this guide, we'll explore effective strategies and resources tailored to help you navigate the intricacies of the English language, ultimately empowering you to communicate confidently and fluently in diverse contexts. Let's embark on this enriching adventure together, as we delve into the myriad ways to learn and master English effectively.
The incidence of retinopathy of prematurity in neonates in Germany in 2019; a nationwide epidemiological cohort study
Creators: name: Alfaar, Ahmad Samir
name: Parlak, Melih
name: Hassanain, Omneya
name: Abdelmaksoud, Eman
name: Wolf, Armin
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: Retinopathy of prematurity
subject: Incidence
subject: Risk factors
subject: Treatment
subject: Mortality
subject: DDC 610 / Medicine & health

description: Abstract Retinopathy of prematurity (ROP) is a leading cause of childhood blindness in preterm infants. The incidence of ROP varies widely across countries, with rates as high as 30% in some regions. This study investigated the incidence, risk factors, treatment, and mortality of ROP patients in Germany. Data were extracted from the German Federal Statistical Office (Destatis) diagnosis-related group (DRG) and Institute for the Remuneration System in Hospitals (InEK) databases. Patients with a secondary diagnosis of ROP (ICD-10 code H35.1) in the first 28 days of life were included. Data were extracted for patients admitted between January 1, 2019 and December 31, 2019. The diagnoses and procedures were determined using the German version of the International Classification of Diseases (ICD-10-GM) and the German procedure coding system (OPS). The codes 5–154.xx, 5–155.xx, 8–020.xx, 5–156.9, 6–003.(c&d), 6–007.(2&8) were utilised to denote different ocular treatments. Patient Clinical Complexity Levels were extracted and used to compare ROP with non-ROP patients. A total of 1326 patients with ROP were identified. The incidence of ROP is estimated to be 17.04 per 10,000 live births. The incidence was highest in infants with birth weights less than 500 g and decreased with increasing birth weight. The most common risk factors for ROP were low birth weight, male sex, and prematurity. Of the infants with ROP, 7.2% required ocular treatment. The most common treatment was intraocular injections, followed by photocoagulation. No surgical treatment was required for any of the infants during the study period. The mortality rate for infants with ROP was 60.33 per 10,000. This is higher than the overall neonatal death rate of 24.2 per 10,000. Conclusions : This study found that the incidence of ROP in Germany is similar to that in other developed countries. The study also found that the mortality rate for infants with ROP is higher than the overall neonatal death rate. These findings highlight the importance of early detection and treatment of ROP in preterm infants. What is Known: • ROP is a severe eye condition often affecting preterm infants. • Previous data are limited in scope and generalizability. What is New: • Based on a national database, our study found ROP incidence to be 17.04 per 10,000 new births, higher in males (17.71) than in females (16.34). • 7.2% of ROP cases required ocular treatment, inversely correlated with birth weight. • High rates of multimorbidity such as neonatal jaundice (84.69%), respiratory distress syndrome (80.84%), and apnea (78.88%) were observed. © In Copyright http://rightsstatements.org/vocab/InC/1.0/
IJTIMOIY XARAKTERDAGI SOLIQ IMTIYOZLARINING FUNKSIYALARI VA QO`LLANILISHI
Creators: name: Maxsadaliyeva, Maftuna
Publisher: name: Zenodo
Year: 2024

description: Mazkur tadqiqot ishimizda soliq imtiyozlarining iqtisodiy mohiyati, ahamiyati, ularni qo’llash tamoyillari, iqtisodiyotni rivojlantirishda soliq imtiyozlarni o`rni, uning afzalliklari va kamchiliklari, milliy soliq tizimida soliq imtiyozlarining holati tahlili, mavjud to`siqlar va muammolar atroflicha to`xtalib o`tilgan.
Mapping the Orgasm Gap in 42 countries: Exploring its Association with Structural, Country-Level Gender Inequality
Creators: name: Bőthe, Beáta
name: Anaïka François
name: Klein, Verena
Publisher: name: OSF Registries
Year: 2024
Subjects: subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: Mapping the Orgasm Gap in 42 countries: Exploring its Association with Structural, Country-Level Gender Inequality
21Master's Dissertation-Efficiency in computer simulation for identification and control of nonlinear systems
Creators: name: Martins, Samir A.
name: Nazaré, Thalita
name: Nepomuceno, Erivelton
Publisher: name: OSF Registries
Year: 2024
Subjects: subject: Dynamical Systems
subject: Physical Sciences and Mathematics
subject: Mathematics
subject: FOS: Mathematics
subject: Engineering
subject: chaos

description: In the OSF project, you will find publications referring to this work and the master's thesis.

To cite this work:
APA: Nazaré, T. E., Martins, S. A., & Nepomuceno, E. G. (2021, September 8). Efficiency in computer simulation for identification and control of nonlinear systems. https://doi.org/10.17605/OSF.IO/R3AW9
Specialization in hierarchical learning systems : a unified information-theoretic approach for supervised, unsupervised and reinforcement learning
Creators: name: Hihn, Heinke
name: Braun, Daniel A.
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Meta-learning
subject: Information theory
subject: Bounded rationality
subject: DDC 000 / Computer science, information & general works
subject: Information theory
subject: Metalernen
subject: Informationstheorie
subject: Eingeschränkte Rationalität

description: Joining multiple decision-makers together is a powerful way to obtain more sophisticated decision-making systems, but requires to address the questions of division of labor and specialization. We investigate in how far information constraints in hierarchies of experts not only provide a principled method for regularization but also to enforce specialization. In particular, we devise an information-theoretically motivated on-line learning rule that allows partitioning of the problem space into multiple sub-problems that can be solved by the individual experts. We demonstrate two different ways to apply our method: (i) partitioning problems based on individual data samples and (ii) based on sets of data samples representing tasks. Approach (i) equips the system with the ability to solve complex decision-making problems by finding an optimal combination of local expert decision-makers. Approach (ii) leads to decision-makers specialized in solving families of tasks, which equips the system with the ability to solve meta-learning problems. We show the broad applicability of our approach on a range of problems including classification, regression, density estimation, and reinforcement learning problems, both in the standard machine learning setup and in a meta-learning setting.
Androgen derivatives improve blood counts and elongate telomere length in adult cryptic dyskeratosis congenita
Creators: name: Kirschner, Martin
name: Vieri, Margherita
name: Kricheldorf, Kim
name: Ferreira, Monica S. Ventura
name: Wlodarski, Marcin W.
name: Schwarz, Michaela
name: Balabanov, Stefan
name: Rolles, Benjamin
name: Isfort, Susanne
name: Koschmieder, Steffen
name: Höchsmann, Britta Elisabeth Hedwig
name: Panse, Jens
name: Brümmendorf, Tim Henrik
name: Beier, Fabian
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: DDC 610 / Medicine & health
subject: Dyskeratosis congenita
subject: Telomere
subject: Androgens
subject: Bone marrow failure disorders
subject: Keratose
subject: Telomer

description: Summary Dyskeratosis Congenita (DKC) is a systemic disorder caused by mutations resulting in impaired telomere maintenance. Clinical features include bone marrow failure and an increased risk of developing hematological malignancies. There are conflicting data whether androgen derivatives (AD) can elongate telomeres in vivo and whether AD treatment enhances the risk of gaining myelodysplastic syndrome‐related mutations. Seven TERC or TERT‐mutated DKC patients underwent AD treatment. All patients revealed hematological response. Telomere length of lymphocytes and granulocytes increased significantly and no MDS‐related mutations were detected. Pending longer follow‐up, treatment with AD seems to represent an efficient and safe therapy for DKC patients.
Non-Pharmacological Fatigue Management Strategies in Neurodegenerative Conditions: A Scoping Review
Creators: name: ALAGEEL, SARAH
name: Hibberd, Jane
name: Dr Katherine Deane
Publisher: name: OSF Registries
Year: 2024
Subjects: subject: Medicine and Health Sciences

description: The scoping review presents a comprehensive analysis of non-pharmacological interventions targeting fatigue in prevalent neurodegenerative conditions, excluding dementias. Covering studies from 2006 to 2023, including 322 systematic reviews and meta-analyses, it meticulously evaluates various interventions' efficacy in alleviating fatigue among individuals with neurodegenerative diseases, notably multiple sclerosis (MS) and Parkinson's disease (PD).

Examining interventions such as cognitive-behavioral therapy (CBT), exercise therapy, motivational interviewing, patient education programs, and acupressure, the review offers detailed insights into their strengths and limitations based on available evidence. It also addresses challenges in comparing interventions due to differences in study methodologies, outcome measures, and participant characteristics.

Moreover, the review highlights the need for future research to expand the evidence base for fatigue management in neurodegenerative diseases beyond MS and PD. It emphasizes the importance of comprehensive reporting, including outcomes, adverse events, and cost-effectiveness analyses, to enhance understanding of intervention efficacy and feasibility.

Overall, the scoping review serves as a crucial resource for researchers, clinicians, and policymakers interested in exploring non-pharmacological approaches to mitigate fatigue in neurodegenerative conditions. It provides valuable insights into the current landscape of fatigue management interventions and identifies areas for further investigation and improvement.
The effect of posterior compression of the facet joints for initial stability and sagittal profile in the treatment of thoracolumbar fractures: a biomechanical study
Creators: name: Ruf, Michael
name: Pitzen, Tobias
name: Nennstiel, Ivo
name: Volkheimer, David
name: Drumm, Jörg
name: Püschel, Klaus
name: Wilke, Hans-Joachim
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Thoracolumbar fractures
subject: Sagittal profile
subject: Posterior compression
subject: Stability
subject: Biomechanical study
subject: SPINE
subject: ANTERIOR
subject: CORPECTOMY
subject: INJURIES
subject: DDC 610 / Medicine & health

description: Abstract Purpose Surgical treatment of thoracolumbar A3-fractures usually comprises posterior fixation—in neutral position or distraction—potentially followed by subsequent anterior support. We hypothesized that additional posterior compression in circumferential stabilization may increase stability by locking the facets, and better restore the sagittal profile. Methods Burst fractures Type A3 were created in six fresh frozen cadaver spine segments (T12–L2). Testing was performed in a custom-made spinal loading simulator. Loads were applied as pure bending moments of ± 3.75 Nm in all six movement axes. We checked range of motion, neutral zone and Cobb’s angle over the injured/treated segment within the following conditions: Intact, fractured, instrumented in neutral alignment, instrumented in distraction, with cage left in posterior distraction, with cage with posterior compression. Results We found that both types of instrumentation with cage stabilized the segment compared to the fractured state in all motion planes. For flexion/extension and lateral bending, flexibility was decreased even compared to the intact state, however, not in axial rotation, being the most critical movement axis. Additional posterior compression in the presence of a cage significantly decreased flexibility in axial rotation, thus achieving stability comparable to the intact state even in this movement axis. In addition, posterior compression with cage significantly increased lordosis compared to the distracted state. Conclusion Among different surgical modifications tested, circumferential fixation with final posterior compression as the last step resulted in superior stability and improved sagittal alignment. Thus, posterior compression as the last step is recommended in these pathologies.
Influence of complexing additives on the reversible deposition/dissolution of magnesium in an ionic liquid
Creators: name: Weber, Isabella
name: Ingenmey, Johannes
name: Schnaidt, Johannes
name: Kirchner, Barbara
name: Behm, Rolf Jürgen
name: Dc.Contributor.Author
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: magnesium batteries
subject: complexing additives
subject: quantum chemical calculations
subject: DDC 540 / Chemistry & allied sciences
subject: Electrochemistry
subject: Magnesium
subject: Elektrochemie

description: Better together: Electrochemical measurements and quantum chemical calculations are presented, which show that addition of crown ether enhances the reversibility of Mg deposition/dissolution from a MgTFSI2-containing ionic liquid by strongly coordinating to Mg2+, weakening the [Mg2+−TFSI−] interaction and TFSI− decomposition. BH4− is assumed to support this by acting both as coordinating ligand and as water scavenger. Aiming at a fundamental understanding of the synergistic effects of different additives on the electrochemical Mg deposition/dissolution in an ionic liquid, we have systematically investigated these processes in a combined electrochemical and theoretical study, using 1-butyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl) imide (BMP-TFSI) as the solvent and a cyclic ether (18-crown-6) and magnesium borohydride as additives. Both crown ether and BH4− improve Mg deposition, its reversibility, and cycling stability. The combined presence of both additives and their concentration relative to that of Mg2+ are decisive for more facile and reversible Mg deposition/dissolution. These results and those of quantum chemical calculations indicate that 18-crown-6 can partly displace TFSI− from its direct coordination to Mg2+. Furthermore, the interaction between Mg2+ and directly coordinated TFSI− is weakened by coordination with 18-crown-6, preventing its Mg+-induced decomposition. Finally, Mg deposition is improved by the weaker overall coordination upon Mg2+ reduction to Mg+.
Weibull, κ-Weibull and other probability distributions
Creators: name: Sparavigna, Amelia Carolina
Publisher: name: Zenodo
Year: 2022
Subjects: κ-Weibull distribution
Weibull distribution
3-parameter extended Weibull distribution
Marshall–Olkin extended distributions
Log-logistic distribution
Hazard function
Modeling failure times
Burr distribution
Exopnentiated Weibull distribution
q-Weibull distribution
Student's t-distribution
Paralogistic distribution
Maximum Likelihood
\kappa-Weibull distribution
kappa-Weibull distribution
κ-exponential
κ-entropy
Gumbel distribution
Gompertz distribution

description: Here we will consider a function of κ-statistics, the κ-Weibull distribution, and compare it to the well-known Weibull distribution. The κ-Weibull will be also compared to the 3-parameter extended Weibull function, obtained according to the Marshall–Olkin extended distributions. The log-logistic distribution will be considered for comparison too, such as the exponentiated Weibull, the Burr and the q-Weibull distributions. The most important observation, coming from the proposed calculations, is that the κ-Weibull hazard function is strongly depending on the values of parameter κ, a parameter which is deeply influencing the behaviour of the tail of the probability distribution. As a consequence, the κ-Weibull function turns out to be quite relevant for generalizations of the Weibull approach to modeling failure times. Discussions about the Maximum Likelihood approach for Weibull, κ-Weibull and Burr distributions will be also given.
Excavations at Milefortlet 21.
Creators: name: Turnbull, Percival
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 98, 61-106
description: Geophysical survey and excavation of Milefortlet 21 at Swarthy Hill (also known locally as Primrose Hill or Bank). Work established that the site had only one period of construction and occupation, probably in the Hadrianic period. This is seen as consistent with the evidence from other Solway sites and indicative of the permanent removal from commission of the sites in this sector after reappraisal of the military need at the time of the first re-occupation of the Tyne-Solway frontier. Includes:
The readiness of German GPs to recommend and conduct cancer screening is associated with patient–physician gender concordance. Results of a survey
Creators: name: Engler, Jennifer
name: Dahlhaus, Anne
name: Güthlin, Corina
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Background: Cancer screening participation rates in Germany differ depending on patients’ gender. International studies have found that patient–physician gender concordance fosters recommendation and conducting of cancer screening, and especially cancer screening for women. Objectives: We aimed to ascertain whether gender concordance influences general practitioners' (GPs’) rating of the usefulness of cancer screening, as well as their recommendations and readiness to conduct cancer screening in general practice in Germany. Methods: For an exploratory cross-sectional survey, 500 randomly selected GPs from all over Germany were asked to fill in a questionnaire on cancer screening in general practice between March and June 2015. We asked them to rate the usefulness of each cancer screening examination, how frequently they recommended and conducted them and whether they viewed GPs or specialists as responsible for carrying them out. We used multiple logistic regression to analyse gender effect size by calculating odds ratios. Results: Our study sample consisted of 139 GPs of which 65% were male. Male and female GPs did not differ significantly in their rating of the general usefulness of any of the specified cancer screening examinations. Male GPs were 2.9 to 6.8 times as likely to consider GPs responsible for recommending and conducting PSA testing and digital rectal examinations and were 3.7 to 7.9 times as likely to recommend and conduct these examinations on a regular basis. Conclusion: Patient–physician gender concordance made it more likely that male-specific cancer screenings would be recommended and conducted, but not female-specific screenings. KEY MESSAGES Male GPs are more likely than female GPs to view GPs as responsible for recommending and conducting male-specific cancer screening.Men consult urologists less frequently than women consult gynaecologists, so male GPs seem to take on the role of ‘doctor for men’. Male GPs are more likely than female GPs to view GPs as responsible for recommending and conducting male-specific cancer screening. Men consult urologists less frequently than women consult gynaecologists, so male GPs seem to take on the role of ‘doctor for men’.
Impact of fluctuating thermal regimes on Drosophila melanogaster survival to cold stress
Creators: name: Javal, Marion
name: Renault, David
name: Colinet, Hervé
Publisher: name: Brill Online
Year: 2016
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Zoology
subject: Environmental Science

description: Temperature directly affects survival, development and reproduction in insects and thereby it is a key environmental driver for geographic distribution and population dynamics. This study aims at testing the survival of Drosophila melanogaster under constant low temperatures (CLTs) (2, 3, 4, and 5°C) vs. fluctuating thermal regimes (FTRs). In the latter, the cold stress period was interrupted daily by 2 h pulses at 20°C. Since acclimation enhances cold tolerance, we tested whether benefits of acclimation can combine with those of FTRs. Since D. melanogaster overwinters as non-reproductive adults, we tested if actively reproducing adults are more susceptible to cold stress than virgin females that have a much reduced reproductive activity. The results show that short interruptions of cold stress enhanced survival of adult flies. Survival was time- and temperature-dependent. Prior acclimation to low temperature allowed flies to better cope with cold stress under CLTs. On the other hand, acclimated flies did not profit from the benefits of FTRs and even showed lower survival under FTRs, probably because flies deacclimated during the periodic warm intervals. Gravid females were overall less cold tolerant than virgin females, and both survived better under FTRs. Cold survival at pupal stage was much lower than at adult stage, and no clear benefit of FTR was observed in this life stage. Our study highlights critical variables to take into account when designing experiments of prolonged exposure to low temperature in insects.
AMPS4
Creators: name: Dennehy, Tara C.
name: Schmader, Toni
name: Hernanto, Jo
Publisher: name: OSF Registries
Year: 2024
Subjects: subject: Social Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: This is an amended pre-registration to change the planned recruitment from equal numbers of men and women to focus on only men due to current difficulties recruiting women via TurkPrime.
A catalogue of recent acquisitions to Tullie House Museum and reported finds from the Cumbrian area 1990-1996. Part I: Tullie House accessions
Creators: name: Richardson, Colin
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 98, 1-60
description: Details over 130 artefacts, from prehistoric to post-medieval and including glass, copper-alloy, silver, iron, lead, jet, pot, stone and flint materials. Coins, jewellery, tools, sculpture, tombstones, horsegear, pottery all figure.
Meditation, Attachment and Forgiveness
Creators: name: Fredrickson, Barbara
name: Stanton, Sarah C. E.
name: Don, Brian
name: Gazder, Taranah
Publisher: name: OSF Registries
Year: 2024
Subjects: subject: Life Sciences
subject: Social Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: This contains a preregistration for a project examining attachment orientations, meditation interventions, and their interactions in predicting forgiveness as an outcome.
IMPACT (IMProving Access to Clinical Trial data) Observatory
Creators: name: Krleza-Jeric, Karmela
Publisher: name: figshare
Year: 2016
Subjects: subject: 119999 Medical and Health Sciences not elsewhere classified
subject: FOS: Other medical sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: 140208 Health Economics
subject: FOS: Economics and business

description:
The IMPACT (IMProving Access to Clinical Trials data) Observatory of ongoing transition in clinical research regarding data sharing. IMPACT Observatory is a project of the IMPACT Initiative and it is funded by NEWFELPRO and hosted by the Department of Research in Biomedicine and Health of the University of Split School of Medicine, in Split, Croatia.

The methodology of the Observatory or natural experiment includes a scoping study, surveys and interviews and the environmental scan of repositories of clinical trial data.
Additional file 1 of Correlation between quality and geographical origins of Leonuri Herba revealed by the qualitative fingerprint profiling and quantitative determination of chemical components
Creators: name: Lam, Kelly Yinching
name: Wang, Yinghao
name: Lam, Tszking
name: Ku, Chuenfai
name: Yeung, Wingping
name: Zhao, Zhongzhen
Publisher: name: figshare
Year: 2022
Subjects: subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Plant Biology

description: Additional file 1. Photograph of Leonuri Herba at seedling stage (upper) and mature stage (lower).
The relationship between dental anxiety and other kinds of anxiety: a naturalistic, cross-sectional and comparative study
Creators: name: Valdes Stauber, Juan
name: Hummel, Kevin
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Odontophobia
subject: Self-efficacy
subject: DDC 150 / Psychology
subject: Dental anxiety
subject: Neuroticism
subject: Fear
subject: Quality of life
subject: Loneliness
subject: Angst
subject: Angststörung
subject: Zahnarzt
subject: Neurotizismus
subject: Furcht
subject: Einsamkeit
subject: Lebensqualität

description: Background Dental anxiety is of public health importance because it leads to postponed dental treatment, which comes with health complications. The present study investigated whether there is a correlation between the degree of dental anxiety and other kinds of anxiety and whether there are prognostic factors for the different kinds of anxiety. Method In the sample (N = 156) from a dental practice in a large German city, 62% of patients received a check-examination and 38% received dental surgery. The target variables were recorded with validated questionnaires: dental anxiety (IDAF-4c+), subclinical anxiety (SubA), anxiety of negative evaluation (SANB-5), current general anxiety (STAI state), loneliness (LS-S) and self-efficacy (GSW-6). The applied statistics were: t-tests for 31 variables, correlation matrix and multivariate and bivariate regression analyses. Results The dental surgery patients displayed more dental anxiety and more dental interventions than the check-examination group. The main result was a positive correlation of all kinds of anxiety with each other, a positive correlation of loneliness and neuroticism with all forms of anxiety and a negative correlation between all forms of anxiety and self-efficacy. Especially dental anxiety is positively associated with other kinds of anxiety. In multivariate regression models only neuroticism is associated with dental anxiety, but feelings of loneliness are positively associated with with the other kinds of anxiety assessed in this study. The higher the self-efficacy, the lower the level of general anxiety. Conclusions In dentistry, anxiety from negative experiences with buccal interventions should be distinguished from anxiety caused by personality traits. Self-efficacy tends to protect against anxiety, while loneliness and neuroticism are direct or indirect risk factors for anxiety in this urban dentistry sample. Dental anxiety seems to be independent from biographical strains but not from neuroticism. In practice, more attention must be paid to anxiety control, self-management and efforts to improve the confidence of patients with emotional lability, less self-confidence and propensity to shame.
Practical large-scale production of dihydrocapsiate, a nonpungent capsaicinoid-like substance
Creators: name: Kurosawa, Wataru
name: Nakano, Takashi
name: Amino, Yusuke
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology

description: Capsinoids represent a novel group of capsaicinoid-like substances found in a nonpungent cultivar, Capsicum annuum “CH-19 Sweet.” They have capsaicinoid-like physiological and biological properties while lacking the harmful stimuli of capsaicinoids. A large-scale synthesis of dihydrocapsiate (DCT) is established in this work. 8-Methynonanoic acid (MNA) was synthesized by copper-catalyzed cross-coupling of ethyl 6-bromohexanoate with isobutylmagnesium bromide and subsequent hydrolysis. Lipase-catalyzed chemoselective esterification of vanillyl alcohol and MNA was performed at 50 °C under reduced pressure to remove water without solvents or drying agents. A slightly larger stoichiometric amount of MNA was used and the purification in the final stage was simplified to leave a small amount of MNA in the product, because we found that the presence of a small amount of MNA is necessary to stabilize DCT. DCT was synthesized according to the production, and stabilization methods described here has been filed as a new dietary ingredient. Dihydrocapsiate was synthesized via lipase-catalyzed chemoselective esterification of vanillyl alcohol and 8-methylnonanoic acid under reduced pressure without solvents.
Two remarkable Cumbrian clay dabbins.
Creators: name: Jennings, Nina
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 97, 257-259
description: Notes two houses -- Greenwoodside and Claywells -- the latter an extraordinarily late example of communal cruck building, having been erected in one day in 1870.
title: OFROM: interview avec unine15a93m
Creators: name: Delafontaine, François
name: Widmer, Aline
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.8ebc20q7.v2#ecda66e370900d58c34b8bba0e475822781809e2
The Chapel in the Hause.
Creators: name: Godwin, Jeremy
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 97, 254-255
description: Notes a rectangular ruined structure situated between Boredale (Martindale) and Patterdale. It was probably, but not certainly, a chapel and its date is not known.
Additional file 2 of Correlation between quality and geographical origins of Leonuri Herba revealed by the qualitative fingerprint profiling and quantitative determination of chemical components
Creators: name: Lam, Kelly Yinching
name: Wang, Yinghao
name: Lam, Tszking
name: Ku, Chuenfai
name: Yeung, Wingping
name: Zhao, Zhongzhen
Publisher: name: figshare
Year: 2022
Subjects: subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Plant Biology

description: Additional file 2: Table S1. Calibration curves, correlation factors, linear ranges, LOD and LOQ for the eight compounds.
Online Interviews as New Methodological Normalcy and a Space of Ethics: An Autoethnographic Investigation into Covid-19 Educational Research
Creators: name: Fan, H
name: Li, Bingqing
name: Pasaribu, Truly
name: Chowdhury, R
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 500106
subject: Medical ethics
classificationCode: 4405
subject: Gender studies
classificationCode: 39
subject: Education
classificationCode: 3904
subject: Specialist studies in education
classificationCode: 44
subject: Human society
classificationCode: 4410
subject: Sociology
subject: FOS: Sociology

description: Worldwide travel restrictions during the Covid-19 pandemic abruptly changed the norms of conducting qualitative research. Online interviews, long regarded as a second choice to their offline counterparts, are no longer seen as supplementary since they emerged as the dominant mode of data collection during the pandemic. This study employs an autoethnographic approach to investigate the authors’ experiences of adjusting to alternative methodological approaches. The investigation critically reflects on how the author’s agencies in allocating and gathering instructional, social, and economic resources led to a researcher identity reconfigured by choices in making ethical commitment in data collection. This article also sheds light on how the authors, constrained by limited resources, gained better understanding of ethics in practice through negotiation with participants and obtained rich data by exercising their agencies. The article argues that researchers need to place both online and offline methods on equal footing to facilitate a more ethically sensitive approach to data collection.
Results of a randomized trial of treatment modalities in patients with low or early-intermediate risk prostate cancer (PREFERE trial)
Creators: name: Wiegel, Thomas
name: Albers, Peter
name: Bartkowiak, Detlef
name: Bussar-Maatz, Roswitha
name: Härter, Martin
name: Kristiansen, Glen
name: Martus, Peter
name: Wellek, Stefan
name: Schmidberger, Heinz
name: Grozinger, Klaus
name: Renner, Peter
name: Schneider, Fried
name: Burmester, Martin
name: Stöckle, Michael
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Prostate cancer
subject: Randomized clinical trial
subject: Prostatectomy
subject: Active surveillance
subject: External beam radiotherapy
subject: Permanent seed implantation
subject: DDC 610 / Medicine & health

description: Abstract Purpose The optimal treatment for patients with low to early-intermediate risk prostate cancer (PCa) remains to be defined. The randomized PREFERE trial (DRKS00004405) aimed to assess noninferiority of active surveillance (AS), external-beam radiotherapy (EBRT), or brachytherapy by permanent seed implantation (PSI) vs. radical prostatectomy (RP) for these patients. Methods PREFERE was planned to enroll 7600 patients. The primary endpoint was disease specific survival. Patients with PCa stage ≤ cT2a, cN0/X, M0, PSA ≤ 10 ng/ml and Gleason-Score ≤ 3 + 4 at reference pathology were eligible. Patients were allowed to exclude one or two of the four modalities, which yielded eleven combinations for randomization. Sixty-nine German study centers were engaged in PREFERE. Results Of 2251 patients prescreened between 2012 and 2016, 459 agreed to participate in PREFERE. Due to this poor accrual, the trial was stopped. In 345 patients reference pathology confirmed inclusion criteria. Sixty-nine men were assigned to RP, 53 to EBRT, 93 to PSI, and 130 to AS. Forty patients changed treatment shortly after randomization, 21 to AS. Forty-eight AS patients with follow-up received radical treatment. Median follow-up was 19 months. Five patients died, none due to PCa; 8 had biochemical progression after radical therapy. Treatment-related acute grade 3 toxicity was reported in 3 RP patients and 2 PSI patients. Conclusions In this prematurely closed trial, we observed an unexpected high rate of termination of AS and an increased toxicity related to PSI. Patients hesitated to be randomized in a multi-arm trial. The optimal treatment of low and early-intermediate risk PCa remains unclear.