cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Lithuanian-Polish security cooperation in European Union (EU) Defence Programs
Creators: name: Piechowicz, Michał
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 440808
subject: International relations

description: This article is part of a broad discussion concerning the deteriorating security environment in the European neighbourhood and the initiatives the European Union (EU) and its Member States (MS) took to intensify security and defence cooperation. The war in Ukraine put pressure on the entire regional security structure. Hence increased investments and more collaboration are necessary to jointly develop and use the military capabilities that the EU and Baltic region need. In this context, it is interesting how Lithuania and Poland-both Eastern EU members with grave concerns and engagement in regional security-perceive and utilize the potential that EU programs offer. This article will look deeper into the level of cooperation between Lithuania and Poland before the intensification of military operations in Ukraine in February 2022. Furthermore, the paper presents an overview of the regional cooperation concept, Common Security and Defence Policy (CSDP), and its funds, agencies, and instruments. The key elements of this study are the analysis of both countries' involvement in the European Defence Fund (EDF) preparatory programs implemented since 2017.
Additional file 1 of Expectations on implementation of a health promotion practice using individually targeted lifestyle interventions in primary health care: a qualitative study
Creators: name: Strid, Emma Nilsing
name: Wallin, Lars
name: Nilsagård, Ylva
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Science Policy
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Computational Biology

description: Additional file 1. Interview guides.
Study of Neutron Magic Drip-Line Nuclei within Relativistic Mean Field plus BCS Approach
Creators: name: Saxena, G.
name: Singh, D.
name: Kaushik, M.
name: Yadav, H. L.
name: Toki, H.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Encouraged by the success of RMF+BCS approach for the description of the ground state properties of the chains of isotopes of proton magic nuclei with proton number Z=8, 20, 28, 50 and 82 as well as those of proton sub-magic nuclei with Z=40, we have further employed it, in an analogous manner, for a detailed calculations of the ground state properties of the neutron magic isotones with neutron number N = 8, 20, 28, 50, 82 and 126 as well as those of neutron sub-magic isotones with N = 40 using the TMA force parameterizations in order to explore low lying resonance and other exotic phenomenon near drip-lines. The results of these calculations for wave-function, single particle pairing gaps etc. are presented here to demonstrate the general validity of our RMF+BCS approach. It is found that, in some of the proton-rich nuclei in the vicinity of the proton drip-line, the main contribution to the pairing correlations is provided by the low-lying resonant states, in addition to the contributions coming from the states close to the Fermi surface, which results extended proton drip-line for isotonic chain.
description: 20 Pages, 9 figures
Additional file 1 of Estimating transmission dynamics and serial interval of the first wave of COVID-19 infections under different control measures: a statistical analysis in Tunisia from February 29 to May 5, 2020
Creators: name: Talmoudi, Khouloud
name: Safer, Mouna
name: Hejer Letaief
name: Hchaichi, Aicha
name: Chahida Harizi
name: Dhaouadi, Sonia
name: Sondes Derouiche
name: Ilhem Bouaziz
name: Gharbi, Donia
name: Nourhene Najar
name: Molka Osman
name: Cherif, Ines
name: Rym Mlallekh
name: Ben-Ayed, Oumaima
name: Yosr Ayedi
name: Bouabid, Leila
name: Bougatef, Souha
name: Nissaf Bouafif ép Ben-Alaya
name: Chahed, Mohamed Kouni
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Figure S1. Maximum likelihood distributions fit to transformed COVID-19 serial intervals (491 reported transmission events in Tunisia between March 1, 2020 and May 5, 2020). To evaluate several positive-valued distributions (lognormal, gamma and Weibull), we took two approaches to addressing the negative-valued data. First, we left truncated the data (i.e., removed all non-positive values) for (A) all infection events. Second, we shifted the data by adding 12 days to each reported serial interval for (B) all infection events. Table S1. Model comparison for COVID-19 serial intervals based on all 491 reported transmission events in Tunisia between March 1, 2020 and May 5, 2020. Table S2. Weekly window reported estimates of the reproduction number (R) during the study period in Tunisia. Figure S2. Overall infectivity between February 29, 2020 and May 5, 2020.
Radiation Response and Regulation of Apoptosis Induced by a Combination of TRAIL and CHX in Cells Lacking Mitochondrial DNA: A Role for NF-KB–STAT3-directed Gene Expression
Creators: name: Ivanov, Vladimir N.
name: Hei, Tom K.
name: Zhou, Hongning
name: Ghandhi, Shanaz
name: Amundson, Sally A.
name: Huang, Sarah X.
name: Chai, Yunfei
Publisher: name: Columbia University
Year: 2011
Subjects: Mitochondrial DNA
Apoptosis
Cytology
Oncology

description: Mitochondrial DNA depleted (ρ0) human skin fibroblasts (HSF) with suppressed oxidative phosphorylation were characterized by significant changes in the expression of 2100 nuclear genes, encoding numerous protein classes, in NF-κB and STAT3 signaling pathways, and by decreased activity of mitochondrial death pathway, compared to the parental ρ+ HSF. In contrast, the extrinsic TRAIL/TRAIL-Receptor mediated death pathway remained highly active, and exogenous TRAIL in a combination with cycloheximide (CHX) induced higher levels of apoptosis in ρ0 cells compared to ρ+ HSF. Global gene expression analysis using microarray and qRT-PCR demonstrated that mRNA expression levels of many growth factors and their adaptor proteins (FGF13, HGF, IGFBP4, IGFBP6, and IGFL2), cytokines (IL6, ΙL17Β, ΙL18, ΙL19, and ΙL28Β) and cytokine receptors (IL1R1, IL21R, and IL31RA) were substantially decreased after mitochondrial DNA depletion. Some of these genes were targets of NF-κB and STAT3, and their protein products could regulate the STAT3 signaling pathway. Alpha-irradiation further induced expression of several NF-κB/STAT3 target genes, including IL1A, IL1B, IL6, PTGS2/COX2 and MMP12, in ρ+ HSF, but this response was substantially decreased in ρ0 HSF. Suppression of the IKK–NF-κB pathway by the small molecular inhibitor BMS-345541 and of the JAK2–STAT3 pathway by AG490 dramatically increased TRAIL-induced apoptosis in the control and irradiated ρ+ HSF. Inhibitory antibodies against IL6, the main activator of JAK2–STAT3 pathway, added into the cell media, also increased TRAIL-induced apoptosis in HSF, especially after alpha-irradiation. Collectively, our results indicated that NF-κB activation was partially lost in ρ0 HSF resulting in downregulation of the basal or radiation-induced expression of numerous NF-κB targets, further suppressing IL6–JAK2–STAT3 that in concert with NF-κB regulated protection against TRAIL-induced apoptosis.
British Columbia Legislative Assembly sessional clipping book (1936-02)
Creators: name: :Unav
Publisher: name: University of Victoria Libraries
Year: 2022
Subjects: subject: Law
valueUri: http://id.worldcat.org/fast/993678
subject: FOS: Law
subject: British Columbia. Legislative Assembly
valueUri: http://id.worldcat.org/fast/600765
subject: Politics and government
valueUri: http://id.worldcat.org/fast/1919741

description: These Sessional Clippings books cover the period 1891 to 1972, and include newspaper accounts written by various legislative reporters who covered debates occurring in the British Columbia Legislative Assembly. Transcripts of debates of the Legislative Assembly (Hansard) were not published in B.C. until 1970; hence these "Sessional Clipping Books" augment the "Journals", the record of daily proceedings of the Legislative Assembly. Selected clippings from various newspapers including the Vancouver Sun, the Vancouver Province, the Colonist, and the Times newspapers, relating to the newspaper reports concerning activities of the Legislature. The original sessional clippings books comprise 351 ledger size print volumes, held at the Legislative Library in Victoria BC. The print volumes were microfilmed onto 26 reels in 1977 under a Tri University Libraries (TRIUL) project by Precision Micrographic Services (Vancouver, B.C.), with the permission of the Legislative Library, Victoria, British Columbia. This digital collection was created by scanning the 26 microfilm reels.
Induction of Apoptotic Death and Retardation of Neuronal Differentiation of Human Neural Stem Cells by Sodium Arsenite Treatment
Creators: name: Ivanov, Vladimir N.
name: Hei, Tom K.
Publisher: name: Columbia University
Year: 2013
Subjects: Neural stem cells
Apoptosis
Cytology
Oncology
Medical sciences

description: Chronic arsenic toxicity is a global health problem that affects more than 100 million people worldwide. Long-term health effects of inorganic sodium arsenite in drinking water may result in skin, lung and liver cancers and in severe neurological abnormalities. We investigated in the present study whether sodium arsenite affects signaling pathways that control cell survival, proliferation and neuronal differentiation of human neural stem cells (NSC). We demonstrated that the critical signaling pathway, which was suppressed by sodium arsenite in NSC, was the protective PI3K–AKT pathway. Sodium arsenite (2–4 μM) also caused down-regulation of Nanog, one of the key transcription factors that control pluripotency and self-renewal of stem cells. Mitochondrial damage and cytochrome-c release induced by sodium arsenite exposure was followed by initiation of the mitochondrial apoptotic pathway in NSC. Beside caspase-9 and caspase-3 inhibitors, suppression of JNK activity decreased levels of arsenite-induced apoptosis in NSC. Neuronal differentiation of NSC was substantially inhibited by sodium arsenite exposure. Overactivation of JNK1 and ERK1/2 and down-regulation of PI3K–AKT activity induced by sodium arsenite were critical factors that strongly affected neuronal differentiation. In conclusion, sodium arsenite exposure of human NSC induces the mitochondrial apoptotic pathway, which is substantially accelerated due to the simultaneous suppression of PI3K–AKT. Sodium arsenite also negatively affects neuronal differentiation of NSC through overactivation of MEK–ERK and suppression of PI3K–AKT.
Another look at the online processing of scalar inferences
Creators: name: Sun, Chao
name: Breheny, Richard
Publisher: name: Humboldt-Universität zu Berlin
Year: 2019
Subjects: subject: Pragmatics
subject: scalar inference
subject: time course
subject: eye-movements
subject: visual-world paradigm
subject: 400 Sprache

description: Previous psycholinguistic studies that compared the time course of interpretation for pragmatic some and literal all have returned mixed results. In particular, a delayed pragmatic some has been found in some studies but not in others. We explain these conflicting findings in terms of factors which are independent of incremental semantic/pragmatic interpretation. Two offline experiments provide evidence of the effect of these factors. Three visual-world studies showed that they influence participants’ eye movements in online comprehension. We introduce a new measure for investigating the time course of scalar inference. This new measure allows us to reason about the time course question based on the difference in verification procedures between numbers and quantifiers. Results from our visual-world studies suggest that deriving the pragmatic interpretation is not delayed relative to the semantic interpretation.
Structure of odd $^{79,81,83}$Se isotopes with proton and neutron excitations across $Z=28$ AND $N= 40$
Creators: name: Kumar, Vikas
name: Srivastava, P. C.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The recently measured experimental data of $^{79,81,83}$Se isotopes have been interpreted in terms of shell model calculations. The calculations have been performed in ${f_{5/2}pg_{9/2}}$ space with the recently derived interactions, namely with JUN45 and jj44b. To study the importance of the proton excitations across the $Z=28$ shell in this region. We have also performed calculation in ${fpg_{9/2}}$ valence space using an ${fpg}$ effective interaction with $^{48}$Ca core and imposing a truncation. Excitation energies, $B(2)$ values, quadrupole moments and magnetic moments are compared with experimental data when available. Present study reveals the importance of proton excitations across the $Z=28$ shell for predicting quadrupole and magnetic moments.
description: 12 pages, 6 figures. arXiv admin note: text overlap with arXiv:1210.5790
Mid-Term Outcome after Aortic Valve Replacement in Tertiary hospital
Creators: name: Laohathai, Sira
name: Montien Ngodngamtaweesuk
name: Piya Samankatiwat
Publisher: name: Text and Journal Publication
Year: 2020
Subjects: aortic valve replacement
cardiac surgery

description: Vajira Medical Journal, 64, 6, 381-388
A Review of Financial Accounting Fraud Detection based on Data Mining Techniques
Creators: name: Sharma, Anuj
name: Panigrahi, Prabin Kumar
Publisher: name: arXiv
Year: 2013
Subjects: subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences

description: With an upsurge in financial accounting fraud in the current economic scenario experienced, financial accounting fraud detection (FAFD) has become an emerging topic of great importance for academic, research and industries. The failure of internal auditing system of the organization in identifying the accounting frauds has lead to use of specialized procedures to detect financial accounting fraud, collective known as forensic accounting. Data mining techniques are providing great aid in financial accounting fraud detection, since dealing with the large data volumes and complexities of financial data are big challenges for forensic accounting. This paper presents a comprehensive review of the literature on the application of data mining techniques for the detection of financial accounting fraud and proposes a framework for data mining techniques based accounting fraud detection. The systematic and comprehensive literature review of the data mining techniques applicable to financial accounting fraud detection may provide a foundation to future research in this field. The findings of this review show that data mining techniques like logistic models, neural networks, Bayesian belief network, and decision trees have been applied most extensively to provide primary solutions to the problems inherent in the detection and classification of fraudulent data.
description: 11 Pages. International Journal of Computer Applications February 2012
A counterexample to the CFT convexity conjecture
Creators: name: Sharon, Adar
name: Watanabe, Masataka
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Motivated by the weak gravity conjecture, arXiv:2108.04594 conjectured that in any CFT, the minimal operator dimension at fixed charge is a convex function of the charge. In this letter we construct a counterexample to this convexity conjecture, which is a clockwork-like model with some modifications to make it a weakly-coupled CFT. We also discuss further possible applications of this model and some modified versions of the conjecture which are not ruled out by the counterexample.
title: ИНТЕГРАЛЬНАЯ ОЦЕНКА ВЗАИМООТНОШЕНИЙ МИКРООРГАНИЗМОВ-АССОЦИАНТОВ ПРИ ВОСПАЛИТЕЛЬНЫХ ЗАБОЛЕВАНИЯХ ТКАНЕЙ ПАРО-ДОНТА НА ЭТАПЕ ПЛАНИРОВАНИЯ ОРТОПЕДИЧЕСКОГО ЛЕЧЕНИЯ
Creators: name: Яковлев, Михаил Владимирович
Publisher: name: Астраханский государственный медицинский университет
Year: 2022
Subjects: subject: Clinical medicine
subject: FOS: Clinical medicine

description: Комплексный подход в стоматологическом лечении требует подготовки зубочелюстной системы к этапу зубного протезирования. При этом воспалительные заболевания пародонта, вызванные активностью условно патогенных микроорганизмов, являются одной из наиболее частых причин отсрочки начала изготовления стоматологических ортопедических конструкций. Представляет интерес оценить качественный и количественный состав микроорганизмов ротовой полости пациентов с очагами воспалительного процесса, а также анализ симбиотических взаимоотношений ее представителей. Материалы и методы. Материал для исследования получали из зубодесневой борозды 22 условно здоровых лиц и 23 пациентов с воспалительными заболеваниями пародонта. Посев биологического материала осуществляли на основные дифференциально-диагностические питательные среды с последующей инкубацией и идентификацией штаммов. Определяли частоту обнаружения в процентах, взаимодействие между отдельными представителями биоценоза с помощью коэффициента сходства Жаккара, а также характер взаимоотношений между двумя видами. Результаты исследования. В качестве постоянных таксонов выделены S. viridans у лиц с выраженным воспалительным процессом в тканях пародонта, а также S. salivarius, Lactobacillus spp. и Corynebacterium spp. у соматически здоровых пациентов. Подобная ситуация представляется настораживающим фактом, так как повышенные количества идентифицированных микроорганизмов в очагах воспаления, характерны для состояния эубиоза ротовой полости. Выявленное наибольшее число антагонистических связей у штамма S. viridans свидетельствует о риске кардинального изменения состава микроорганизмов при возникновении воспалительного процесса мягкотканного пародонта полости рта. Полученные количественные данные и результаты индексного анализа дают возможность суждения о патогенном потенциале микробиоты исследуемого биотопа в целом, что необходимо учитывать при планировании ортопедического лечения.
Baroclinic Instability in Stellar Radiation Zones
Creators: name: Kitchatinov, Leonid L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Surfaces of constant pressure and constant density do not coincide in differentially rotating stars. Stellar radiation zones with baroclinic stratification can be unstable. Instabilities in radiation zones are of crucial importance for angular momentum transport, mixing of chemical species and, possibly, for magnetic field generation. This paper performs linear analysis of baroclinic instability in differentially rotating stars. Linear stability equations are formulated for differential rotation of arbitrary shape and then solved numerically for rotation non-uniform in radius. As the differential rotation increases, r- and g-modes of initially stable global oscillations transform smoothly into growing modes of baroclinic instability. The instability can therefore be interpreted as stability loss to r- and g-modes excitation. Regions of stellar parameters where r- or g-modes are preferentially excited are defined. Baroclinic instability onsets at a very small differential rotation of below 1%. The characteristic time of instability growth is about one thousand rotation periods. Growing disturbances possess kinetic helicity. Magnetic field generation by the turbulence resulting from baroclinic instability in differentially rotating radiation zones is, therefore, possible.
description: 9 pages, 7 figures, to appear in ApJ
title: Plio-Pleistocene Paleoceonography of the Ross Sea, Antarctica Based on Foraminifera from IODP sites U1523, U1522, and U1521
Creators: name: Seidenstein, Julia
Publisher: name: University of Massachusetts Amherst
Year: 2020

description: The West Antarctic Ice Sheet (WAIS) is currently thinning and retreating because shifting oceanic currents are transporting warmer waters to the ice margin, which could lead to a collapse of the ice sheet and global sea level rise. International Ocean Discovery Program (IODP) Expedition 374 sailed to the Ross Sea in 2018 to study the history of the WAIS over the last 20 million years. Previous geologic drilling projects into Ross Sea sediments that record the history of the WAIS (DSDP Leg 28, RISP, MSSTS, Cape Roberts Drilling Project, ANDRILL), as well as modeling studies, show considerable variability of ice-sheet extent during the Neogene and Quaternary including ice sheet collapse during times of extreme warmth.
The purpose of this study is to reconstruct paleoenvironments on the Ross Sea and confirm modeling studies that show warming waters in the Southern Ocean led to the loss of Antarctic ice in the past. Site U1523 is a key site as it is located close to the shelf break and therefore sensitive to warm water incursions from modified Circumpolar Deep Water (mCDW) onto the Ross Sea continental shelf as the Antarctic Slope Current weakens with a changing climate. Shelf sites U1522 and U1521 provide perspective for what was happening closer to the Ross Ice Shelf. Multiple incursions of subpolar or temperate planktic foraminifera taxa occurred during the latest Pliocene and early Pleistocene prior to ~1.8 Ma at Site U1523 indicating times of warmer than present conditions and less ice in the Ross Sea. Especially high abundances of foraminifera are recorded in the late Pleistocene associated with Marine Isotope Stage (MIS) 31, MIS 11, and MIS 5e might also indicate reduced ice and relatively warmer conditions. The interval of abundant foraminifera around MIS 31 (MIS 37 to 21) suggests multiple warmer interglacials during the Mid-Pleistocene Transition (MPT). A change in benthic foraminiferal assemblages and a large increase in foraminiferal fragments after the MPT (~800 ka) indicate stronger currents at the seafloor and perhaps corrosive waters, suggesting a major change in water masses entering (mCDW) or exiting the Ross Sea (AABW) since the MPT.
Тезисы международной молодежной школы и конференции по вычислительно-информационным технологиям для наук об окружающей среде CITES-2023
Creators: name: ред. Гордов Е.П.
Publisher: name: Zenodo
Year: 2023
Subjects: моделирование климата, окружающая среды, климатические изменения

description: В сборнике представлены тезисы докладов участников Международной конференции по вычислительно-информационным технологиям для наук об окружающей среде CITES-2023
Detecting Thom faults in stratified mappings
Creators: name: Trivedi, Saurabh
name: Trotman, David
Publisher: name: arXiv
Year: 2013
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: We state and prove several characterizations of Thom's regularity condition for stratified maps. In particular we extend to stratified maps some characterizations of Whitney (a) regularity, due to the second author.
description: 14 pages, 4 figures
Desktop Interface for Freesound-based Sampler Audio Plugin
Creators: name: Atabay, Sultan Eylem
Publisher: name: Zenodo
Year: 2022
Subjects: Freesound; Internet of Things(IOT); Smart Musical Instruments; Sampler Software; Digital Music Instrument

description: Began as an open-source, hardware music sampler, SOURCE is powered by the extensive collection of Freesound. It benefits from Freesound API to retrieve sounds for the user to work on their creative musical process. The first appearance of SOURCE stood as a proof of concept device that shows the interaction between the hardware device and online sound collection can be managed. On top of hardware implementation, SOURCE was designed to work on a desktop as a stand-alone or audio plugin. In this thesis, a new interface to enhance the user experience by the fundamental design rules and basics of human-computer interaction is designed. The old interface was analyzed according to visual design rules such as Gestalt Principles and semantically organized for the visual counterpart for the conceptual design. Afterward, the implementation of the new interface was realized by benefiting from third-party libraries in the defined tech stack. The outcome of this thesis and the First interface were evaluated by Creativity Support Index to measure the quality of the new interface due to its nature as a creativity support tool. The result has shown the improvement in the creative aspect of the SOURCE but the small data sample size (N=3) led us not to draw solid conclusions. Nevertheless, as future steps, the possible features that can be added to the SOURCE are provided in the conclusions.
A Neural Network based Approach for Predicting Customer Churn in Cellular Network Services
Creators: name: Sharma, Anuj
name: Panigrahi, Dr. Prabin Kumar
Publisher: name: arXiv
Year: 2013
Subjects: subject: Neural and Evolutionary Computing (cs.NE)
subject: Computational Engineering, Finance, and Science (cs.CE)
subject: FOS: Computer and information sciences

description: Marketing literature states that it is more costly to engage a new customer than to retain an existing loyal customer. Churn prediction models are developed by academics and practitioners to effectively manage and control customer churn in order to retain existing customers. As churn management is an important activity for companies to retain loyal customers, the ability to correctly predict customer churn is necessary. As the cellular network services market becoming more competitive, customer churn management has become a crucial task for mobile communication operators. This paper proposes a neural network based approach to predict customer churn in subscription of cellular wireless services. The results of experiments indicate that neural network based approach can predict customer churn.
description: 6 Pages. International Journal of Computer Applications August 2011
Arsenite Sensitizes Human Melanomas to Apoptosis via Tumor Necrosis Factor α-Mediated Pathway
Creators: name: Ivanov, Vladimir N.
name: Hei, Tom K.
Publisher: name: Columbia University
Year: 2004
Subjects: Melanoma
Apoptosis
Cytology
Oncology
Toxicology

description: Arsenic is a well established human carcinogen and is associated with a variety of cancers including those of the skin. Paradoxically, arsenic has also been used, amid at low doses, in the treatment of leukemia for over a century. Here we demonstrate that low to moderate concentrations of arsenite (2-10 μm) that has little or no effect on normal melanocytes may induce apoptosis of human melanomas including highly metastatic ones despite their low surface Fas levels. The two prerequisites that dictate apoptotic response of melanomas upon arsenite treatment are low nuclear NF-κB activity and an endogenous expression of tumor necrosis factor α. Under these conditions, melanoma cells acquired sensitivity to tumor necrosis factor α-mediated killing. On the other hand, signaling pathways including those of phosphatidylinositol 3-kinase-AKT, MEK-ERK, and JNK play a protective role against arsenite-induced oxidative stress and apoptosis in melanoma cells. Suppression of these pathways dramatically accelerates arsenite-induced apoptosis. Taken together, these data could provide potential approaches to sensitize melanomas to the cytotoxic effects of arsenite through modulating the signaling pathways.
Dual Treatment with COX-2 Inhibitor and Sodium Arsenite Leads to Induction of Surface Fas Ligand Expression and Fas-Ligand-mediated Apoptosis in Human Melanoma Cells
Creators: name: Ivanov, Vladimir N.
name: Hei, Tom K.
Publisher: name: Columbia University
Year: 2006
Subjects: Melanoma
Apoptosis
Cytology
Oncology

description: Most human melanomas express Fas receptor on the cell surface, and treatment with exogenous Fas Ligand (FasL) efficiently induces apoptosis of these cells. In contrast, endogenous surface expression of FasL is suppressed in Fas-positive melanomas. We report here the use of a combination of sodium arsenite, an inhibitor of NF-κB activation, and NS398, a cyclooxygenase-2 (COX-2) inhibitor, for restoration of the surface FasL expression. We observed a large increase of Fas-mediated apoptosis in Fas-positive melanomas. This was due to induction of FasL surface expression and increased susceptibility to Fas death signaling after arsenite and NS398 treatment. Furthermore, silencing COX-2 expression by specific RNAi also effectively increased surface FasL expression following arsenite treatment. Upregulation of the surface FasL levels was based on an increase in the efficiency of translocation to the cell surface and stabilization of FasL protein on the cell surface, rather than on acceleration of the FasL gene transcription. Data obtained demonstrate that the combination of arsenite with inhibitors of COX-2 may affect the target cancer cells via induction of FasL-mediated death signaling.
British Columbia Legislative Assembly sessional clipping book (1936-10)
Creators: name: :Unav
Publisher: name: University of Victoria Libraries
Year: 2022
Subjects: subject: Law
valueUri: http://id.worldcat.org/fast/993678
subject: FOS: Law
subject: British Columbia. Legislative Assembly
valueUri: http://id.worldcat.org/fast/600765
subject: Politics and government
valueUri: http://id.worldcat.org/fast/1919741

description: These Sessional Clippings books cover the period 1891 to 1972, and include newspaper accounts written by various legislative reporters who covered debates occurring in the British Columbia Legislative Assembly. Transcripts of debates of the Legislative Assembly (Hansard) were not published in B.C. until 1970; hence these "Sessional Clipping Books" augment the "Journals", the record of daily proceedings of the Legislative Assembly. Selected clippings from various newspapers including the Vancouver Sun, the Vancouver Province, the Colonist, and the Times newspapers, relating to the newspaper reports concerning activities of the Legislature. The original sessional clippings books comprise 351 ledger size print volumes, held at the Legislative Library in Victoria BC. The print volumes were microfilmed onto 26 reels in 1977 under a Tri University Libraries (TRIUL) project by Precision Micrographic Services (Vancouver, B.C.), with the permission of the Legislative Library, Victoria, British Columbia. This digital collection was created by scanning the 26 microfilm reels.
Multi-region relaxed magnetohydrodynamics with flow
Creators: name: Dennis, G. R.
name: Hudson, S. R.
name: Dewar, R. L.
name: Hole, M. J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: We present an extension of the multi-region relaxed magnetohydrodynamics (MRxMHD) equilibrium model that includes plasma flow. This new model is a generalization of Woltjer's model of relaxed magnetohydrodynamics equilibria with flow. We prove that as the number of plasma regions becomes infinite our extension of MRxMHD reduces to ideal MHD with flow. We also prove that some solutions to MRxMHD with flow are not time-independent in the laboratory frame, and instead have 3D structure which rotates in the toroidal direction with fixed angular velocity. This capability gives MRxMHD potential application to describing rotating 3D MHD structures such as 'snakes' and long-lived modes.
description: 11 pages, 2 figures
NGC 1068 constraints on neutrino-dark matter scattering
Creators: name: Cline, James M.
name: Puel, Matteo
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The IceCube collaboration has observed the first steady-state point source of high-energy neutrinos, coming from the active galaxy NGC 1068. If neutrinos interacted strongly enough with dark matter, the emitted neutrinos would have been impeded by the dense spike of dark matter surrounding the supermassive black hole at the galactic center, which powers the emission. We derive a stringent upper limit on the scattering cross section between neutrinos and dark matter based on the observed events and theoretical models of the dark matter spike. The bound can be stronger than that obtained by the single IceCube neutrino event from the blazar TXS 0506+056 for some spike models.
description: 11 pages, 5 figures; v2: 14 pages, 6 figures, added section about astrophysical uncertainties, updated the results in Figures 3 and 5 and improved the manuscript with clarifications and references. This version matches the accepted version
Variable Stars and Galactic Structure
Creators: name: Feast, Michael W.
name: Whitelock, Patricia A.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Variable stars have a unique part to play in Galactic astronomy. Among the most important of these variables are the Cepheids (types I and II), the RR Lyraes and the Miras (O- and C-rich). The current status of the basic calibration of these stars in their roles as distance, structure and population indicators is outlined and some examples of recent applications of these stars to Galactic and extragalactic problems is reviewed. The expected impact of Gaia on this type of work is discussed and the need for complementary ground based observations, particularly large scale near-infrared photometry, is stressed.
description: IAUS 298 Setting the scene for Gaia and LAMOST, 12 page review with 11 figures
Additional file 2 of High prevalence of SARS-CoV-2 infection among symptomatic healthcare workers in a large university tertiary hospital in São Paulo, Brazil
Creators: name: Buonafine, Carolina Palamin
name: Paiatto, Beatriz Nobre Monteiro
name: Fabyano Bruno Leal
name: Matos, Samantha Faria De
name: Morais, Camila Ohomoto De
name: Guerra, Giovanna Guazzelli
name: Martuchelli, Marcus Vinicius Vidal
name: Oliveira, Danielle Bruna Leal
name: Durigon, Edison Luiz
name: Soares, Camila Pereira
name: Candido, Erika Donizette
name: Telezynski, Bruna Larotonda
name: Sáfadi, Marco Aurélio Palazzi
name: Almeida, Flávia Jacqueline
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 2: Supplementary file 2. Follow-Up Questionnaire. Questionnaire completed after 15 days since the onset of symptoms, with information on symptoms and duration, including interventions, for HCWs who tested Positive for SARS-CoV-2.
Resveratrol Sensitizes Melanomas to TRAIL Through Modulation of Antiapoptotic Gene Expression
Creators: name: Ivanov, Vladimir N.
name: Hei, Tom K.
name: Partridge, Michael A.
name: Johnson, Geoffrey E.
name: Huang, Sarah X. L.
Publisher: name: Columbia University
Year: 2008
Subjects: Melanoma
Resveratrol
Apoptosis
Cytology
Oncology

description: Although many human melanomas express the death receptors TRAIL-R2/DR5 or TRAIL-R1/DR4 on cell surface, they often exhibit resistance to exogenous TRAIL. One of the main contributors to TRAIL-resistance of melanoma cells is upregulation of transcription factors STAT3 and NF-κB that control the expression of antiapoptotic genes, including cFLIP and Bcl-xL. On the other hand, the JNK-cJun pathway is involved in the negative regulation of cFLIP (a caspase-8 inhibitor) expression. Our observations indicated that resveratrol, a polyphenolic phytoalexin, decreased STAT3 and NF-κB activation, while activating JNK-cJun that finally suppressed expression of cFLIP and Bcl-xL proteins and increased sensitivity to exogenous TRAIL in DR5-positive melanomas. Interestingly, resveratrol did not increase surface expression of DR5 in human melanomas, while γ-irradiation or sodium arsenite treatment substantially upregulated DR5 expression. Hence, an initial increase in DR5 surface expression (either by γ-irradiation or arsenite), and subsequent downregulation of antiapoptotic cFLIP and Bcl-xL (by resveratrol), appear to constitute an efficient approach to reactivate apoptotic death pathways in TRAIL-resistant human melanomas. In spite of partial suppression of mitochondrial function and the mitochondrial death pathway, melanoma cells still retain the potential to undergo the DR5-mediated, caspase-8-dependent death pathway that could be accelerated by either an increase in DR5 surface expression or suppression of cFLIP. Taken together, these results suggest that resveratrol, in combination with TRAIL, may have a significant efficacy in the treatment of human melanomas.
Intimate Partner Sexual Violence
Creators: name: Conner, Mackenzie
name: Helps, Nicola
name: Montgomery, Isobel
Publisher: name: Monash University
Year: 2022
Subjects: Gender and crime
Gender studies not elsewhere classified
Criminology not elsewhere classified
Sociology not elsewhere classified

description: Most sexual violence (SV) experienced by women is perpetrated by intimate partners (Australian Bureau of Statistics (ABS) 2017), and intimate partner sexual violence (IPSV) is a significant indicator of escalating frequency and severity of intimate partner violence (IPV). IPSV is both SV and IPV, yet it is not wholly captured within either of these domains and warrants separate attention.
Sodium Arsenite Accelerates TRAIL-Mediated Apoptosis in Melanoma Cells Through Upregulation of TRAIL-R1/R2 Surface Levels and Downregulation of cFLIP Expression
Creators: name: Ivanov, Vladimir N.
name: Hei, Tom K.
Publisher: name: Columbia University
Year: 2006
Subjects: Melanoma
Apoptosis
Cytology
Oncology

description: AP-1/cJun, NF-κB and STAT3 transcription factors control expression of numerous genes, which regulate critical cell functions including proliferation, survival and apoptosis. Sodium arsenite is known to suppress both the IKK-NF-κB and JAK2-STAT3 signaling pathways and to activate the MAPK/JNK-cJun pathways, thereby committing some cancers to undergo apoptosis. Indeed, sodium arsenite is an effective drug for the treatment of acute promyelocytic leukemia with little nonspecific toxicity. Malignant melanoma is highly refractory to conventional radio- and chemotherapy. In the present study, we observed strong effects of sodium arsenite treatment on upregulation of TRAIL-mediated apoptosis in human and mouse melanomas. Arsenite treatment upregulated surface levels of death receptors, TRAIL-R1 and TRAIL-R2, through increased translocation of these proteins from cytoplasm to the cell surface. Furthermore, activation of cJun and suppression of NF-κB by sodium arsenite resulted in upregulation of the endogenous TRAIL and downregulation of the cFLIP gene expression (which encodes one of the main anti-apoptotic proteins in melanomas) followed by cFLIP protein degradation and, finally, by acceleration of TRAIL-induced apoptosis. Direct suppression of cFLIP expression by cFLIP RNAi also accelerated TRAIL-induced apoptosis in these melanomas, while COX-2 suppression substantially increased levels of both TRAIL-induced and arsenite-induced apoptosis. In contrast, overexpression of permanently active AKTmyr inhibited TRAIL-mediated apoptosis via downregulation of TRAIL-R1 levels. Finally, AKT overactivation increased melanoma survival in cell culture and dramatically accelerated growth of melanoma transplant in vivo, highlighting a role of AKT suppression for effective anticancer treatment.
Additional file 1 of High prevalence of SARS-CoV-2 infection among symptomatic healthcare workers in a large university tertiary hospital in São Paulo, Brazil
Creators: name: Buonafine, Carolina Palamin
name: Paiatto, Beatriz Nobre Monteiro
name: Fabyano Bruno Leal
name: Matos, Samantha Faria De
name: Morais, Camila Ohomoto De
name: Guerra, Giovanna Guazzelli
name: Martuchelli, Marcus Vinicius Vidal
name: Oliveira, Danielle Bruna Leal
name: Durigon, Edison Luiz
name: Soares, Camila Pereira
name: Candido, Erika Donizette
name: Telezynski, Bruna Larotonda
name: Sáfadi, Marco Aurélio Palazzi
name: Almeida, Flávia Jacqueline
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Supplementary file 1. Questionnaire. Questionnaire with data on demographical, clinical, and epidemiological information.
Confronting Dark Energy Anisotropic Stress
Creators: name: Chang, Baorong
name: Xu, Lixin
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We use the currently available cosmic observations to probe and constrain an imperfect dark energy fluid which is characterized by a constant equation of state $w$ and a constant speed of viscosity $c^2_{vis}$. The model parameter space was scanned by using Markov chain Monte Carlo method. The results show that the speed of viscosity $c^2_{vis}$ was not well constrained when currently available date sets, which include the cosmic microwave background radiation from {\it Planck}2013, type Ia supernovae and baryon acoustic oscillations, are used. But the cosmic data sets favor phantom dark energy with a negative speed of viscosity $c^2_{vis}$ slightly.
description: 5 pages, 2 figures, code bugs removed, references added, CAMB code modification was described briefly
Radiation-Induced Bystander Signaling Pathways in Human Fibroblasts: A Role for Interleukin-33 in the Signal Transmission
Creators: name: Ivanov, Vladimir N.
name: Hei, Tom K.
name: Zhou, Hongning
name: Ghandhi, Shanaz
name: Karasic, Thomas B.
name: Yaghoubian, Benjamin
name: Amundson, Sally A.
Publisher: name: Columbia University
Year: 2010
Subjects: Fibroblasts
Radiotherapy
Cytology
Oncology

description: The main goal of this study is to elucidate the mechanisms of the signal transmission for radiation-induced bystander response. The NF-κB-dependent gene expression of IL8, IL6, PTGS2/COX2, TNF and IL33 in directly irradiated human skin fibroblasts produced the cytokines and prostaglandin E2 (PGE2) with autocrine/paracrine functions, which further activated signaling pathways and induced NF-κB-dependent gene expression in bystander cells. As a result, bystander cells also started expression and production of interleukin-8, interleukin-6, COX-2-generated PGE2 and interleukin-33 (IL-33) followed by autocrine/paracrine stimulation of the NF-κB and MAPK pathways. A blockage of IL-33 transmitting functions with anti-IL-33 monoclonal antibody added into the culture media decreased NF-κB activation in directly irradiated and bystander cells. On the other hand, the IGF-1-Receptor kinase regulated the PI3K–AKT pathway in both directly irradiated and bystander fibroblasts. A pronounced and prolonged increase in AKT activity after irradiation was a characteristic feature of bystander cells. AKT positively regulated IL-33 protein expression levels. Suppression of the IGF-R1–AKT–IL-33 pathway substantially increased radiation-induced or TRAIL-induced apoptosis in fibroblasts. Taken together, our results demonstrated the early activation of NF-κB-dependent gene expression first in directly irradiated and then bystander fibroblasts, the further modulation of critical proteins, including IL-33, by AKT in bystander cells and late drastic changes in cell survival and in enhanced sensitivity to TRAIL-induced apoptosis after suppression of the IGF-1R–AKT–IL-33 signaling cascade in both directly irradiated and bystander cells.
title: A Stylometric Analysis of Climate Change Fiction
Creators: name: Lorenz, Nina
Publisher: name: University of Massachusetts Amherst
Year: 2020

description: This work sets out to analyze stylistic changes in Anthropocene fiction over the past 60 years. The starting point for the analysis has been Rachel Carson, and the presumed beginning of the Anthropocene in the 1960s. The primary insight gained reveals the connections within these novel and relations of similar writing about climate change thereby contributing to the field of Environmental Humanities in a fundamental way, as so far, climate change fiction has only been investigated through a topic centered focus.
The corpus compiled for scrutiny here extends to over 84 novels from these years. These novels have been selected based on a dual approach, looking at the secondary literature as well as a crowdsourced approach in looking at Good Reads’ cli-fi lists. The resulting texts are then analyzed with stylo, an R package that has been specifically created for stylometric analysis by humanists. The results are visualized in a network that allows easier interpretation and leads to an understanding of more detailed questions about the nature of the connection between works, the inspiration and representation of a specific genre of writing. Moreover, the thesis looks diachronically at clustering based on time and topic. Understanding the ways in which authors address and have addressed climate change is one indicator of how climate change is and has been comprehended.
In terms of the digital approach applied here, the basis is a distant reading approach covering a larger number of novels and rather than close reading them, the task is to find patterns that extend throughout. However, for a thorough analysis, scalable reading is applied to contextualize and investigate the results in more depth. Overall, the results are meant to establish a baseline for discussing climate change fiction in the Anthropocene which although gaining more scholarly attention still is understudied. The hope is to not only gain insight but to generate visualizations that will provide a helpful resource for fellow scholars.
Radiation Induced Non-targeted Response: Mechanism and Potential Clinical Implications
Creators: name: Ivanov, Vladimir N.
name: Hei, Tom K.
name: Zhou, Hongning
name: Chai, Yunfei
name: Ponnaiya, Brian
Publisher: name: Columbia University
Year: 2011
Subjects: DNA
Radiotherapy
Cytology
Oncology

description: Generations of students in radiation biology have been taught that heritable biological effects require direct damage to DNA. Radiation-induced non-targeted/bystander effects represent a paradigm shift in our understanding of the radiobiological effects of ionizing radiation in that extranuclear and extracellular effects may also contribute to the biological consequences of exposure to low doses of radiation. Although radiation induced bystander effects have been well documented in a variety of biological systems, including 3D human tissue samples and whole organisms, the mechanism is not known. There is recent evidence that the NF-κB-dependent gene expression of interleukin 8, interleukin 6, cyclooxygenase- 2, tumor necrosis factor and interleukin 33 in directly irradiated cells produced the cytokines and prostaglandin E2 with autocrine/paracrine functions, which further activated signaling pathways and induced NF-κB-dependent gene expression in bystander cells. The observations that heritable DNA alterations can be propagated to cells many generations after radiation exposure and that bystander cells exhibit genomic instability in ways similar to directly hit cells indicate that the low dose radiation response is a complex interplay of various modulating factors. The potential implication of the non-targeted response in radiation induced secondary cancer is discussed. A better understanding of the mechanism of the non-targeted effects will be invaluable to assess its clinical relevance and ways in which the bystander phenomenon can be manipulated to increase therapeutic gain in radiotherapy.