cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The effect of selected rest intervals on total work volume and blood lactate levels during high intensity elbow flexion exercise at a fixed relative resistance.
Creators: name: Ablack, David.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Biology, Animal Physiology.

description: A group of male subjects (N = 8) were used to examine the effects of two selected rest intervals on total work volume and blood lactate during a maximal effort elbow flexion resistance exercise performed at a fixed relative resistance (70% IRM). The rest intervals were set at 30 seconds (R$\sb{30}$) and 180 seconds (R$\sb{180}$) and were based on the half and full recovery times respectively of the high energy creatine phosphate (CP) system. The exercise continued until a computerized light sensor system detected a movement speed decrease to a pre-determined level of fatigue. R$\sb{180}$ resulted in a significantly greater volume of work (247%) achieved without a statistically significant increase in blood lactate (10%) compared to R$\sb{30}$. It was concluded that a rest interval between repeats of elbow flexion exercise of 180 seconds versus 30 seconds significantly increased the ability to do work without a significant increase in the contribution of the anaerobic lactic system. (Abstract shortened by UMI.)
Attenuation of landfill leachate by a natural marshland system.
Creators: name: La Forge, François.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Engineering, Sanitary and Municipal.

description: Since the early 1980's, leachate originating form the Alice and Fraser municipal landfill has been discharging in a natural marshland system located some 300 meters downgradient form the waste disposal site. However, monitoring of the water quality within the marshland indicates that the contaminant level has not yet surpassed background concentration downstream from the main impact area. A mathematical model was developed in an attempt to predict the mobility of several contaminant species within the marshland environment. Parameters needed for the predictive model were gathered based on the physical configuration of the landfill and marshland associated with laboratory derived data on the attenuation capacity of the marshland soil matrix. The behavior, transport and ultimate fate of contaminants in organic soil is greatly affected by their participation in sorption reactions. The adsorption potential of lead, zinc, calcium, sodium and pentachlorophenol (PCP) by marshland soil was evaluated in laboratory through both, batch and column experiments. A multidimensional finite-difference model based on the Advection-Dispersion Equation was used to predict the migration of the above mentioned contaminants. (Abstract shortened by UMI.)
Geometry of capillary networks during normal and pathological growth of the rat myocardium.
Creators: name: Batra, Sanjay.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1991
Subjects: subject: Biology, Animal Physiology.

description: The aim of this dissertation was to provide a thorough description of the coronary microvasculature at different phases of cardiac contraction, during normal postnatal growth, and pathologically accelerated growth due to pressure and volume overloading. The histochemical technique used to visualize capillaries was novel in that it served to distinguish arteriolar and venular capillary regions by colour. Arteriolar capillary (AC) regions stained blue in colour, positive for the presence of Alkaline Phosphatase in the endothelium. Venular capillary (VC) regions stained red in colour, positive for the presence of Dipeptidyl Peptidase IV. The morphometric methods used to assess capillary geometry from cross and longitudinal tissue sections were classified according to AC and VC regions. From tissue cross sections, capillaries were represented as a bivariate (CV, blue; VC, red) point pattern in the tissue plane. Our software program for capillary domains served to divide the plane into polygonal regions of tissue, each polygon enclosing one capillary. The area subtended by each polygon, the capillary domain, was closer to the enclosed capillary than any other. From individual domain areas, the equivalent radius of the Krogh cylinder with the same area was calculated. As the distribution of these radii is log-normal, the variability was best characterized by the logarithmic standard deviation (SDlog). In this manner, SDlog, the heterogeneity of capillary spacing was determined. From longitudinal sections, scale drawings of capillary sets, which consisted of all the capillary pathways that could be clearly followed from the same terminal arteriole to collecting venule served as the basic unit of study. From these capillary sets, we have defined and measured several morphometric parameters, appropriate as indicators of geometrical conditions for oxygen supply. Among these parameters are the minimal capillary length, the shortest contiguous pathway from arteriole to venule; mean capillary length, the average length of all possible capillary paths from arteriole to venule; and capillary segment length, the distance between two successive capillary branch points. To illustrate the effect of changes in capillary geometry on myocardial oxygenation, we have chosen as an illustration, the results obtained from pressure overloaded hearts. (Abstract shortened by UMI.)
The Genetic Relationship between Leishmania aethiopica and Leishmania tropica Revealed by Comparing Microsatellite Profiles
Creators: name: Krayter, Lena
name: Schnur, Lionel F.
name: Schönian, Gabriele
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Leishmania (Leishmania) aethiopica and L. (L.) tropica cause cutaneous leishmaniases and appear to be related. L. aethiopica is geographically restricted to Ethiopia and Kenya; L. tropica is widely dispersed from the Eastern Mediterranean, through the Middle East into eastern India and in north, east and south Africa. Their phylogenetic inter- relationship is only partially revealed. Some studies indicate a close relationship. Here, eight strains of L. aethiopica were characterized genetically and compared with 156 strains of L. tropica from most of the latter species' geographical range to discern the closeness. Methodology/Principal Findings Twelve unlinked microsatellite markers previously used to genotype strains of L. tropica were successfully applied to the eight strains of L. aethiopica and their microsatellite profiles were compared to those of 156 strains of L. tropica from various geographical locations that were isolated from human cases of cutaneous and visceral leishmaniasis, hyraxes and sand fly vectors. All the microsatellite profiles were subjected to various analytical algorithms: Bayesian statistics, distance-based and factorial correspondence analysis, revealing: (i) the species L. aethiopica, though geographically restricted, is genetically very heterogeneous; (ii) the strains of L. aethiopica formed a distinct genetic cluster; and (iii) strains of L. aethiopica are closely related to strains of L. tropica and more so to the African ones, although, by factorial correspondence analysis, clearly separate from them. Conclusions/Significance The successful application of the 12 microsatellite markers, originally considered species-specific for the species L. tropica, to strains of L. aethiopica confirmed the close relationship between these two species. The Bayesian and distance-based methods clustered the strains of L. aethiopica among African strains of L. tropica, while the factorial correspondence analysis indicated a clear separation between the two species. There was no correlation between microsatellite profiles of the eight strains of L. aethiopica and the type of leishmaniasis, localized (LCL) versus diffuse cutaneous leishmaniasis (DCL), displayed by the human cases.
An examination of mental factors associated with excellence in exceptional Japanese athletes: A holistic approach.
Creators: name: Imai, Kyoko.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Psychology, Psychobiology.

description: This study was designed to gain a better understanding of the phenomenon of athletic excellence with regard to the mental aspects. The information was derived from the interviews with nine highly successful Japanese athletes. A thorough analysis of their experiences, feelings, and insights uncovered various mental factors underlying their athletic success. Content analyses of the interview data resulted in the identification of six main topic areas: (1) growth and development of exceptional athletes, (2) athletes' views on their sports and lives, (3) mental approaches to daily practice, (4) mental approaches to competitions, (5) psychological enhancement strategies, and (6) mental elements essential to athletic success. Based on the interview findings in these six main topic areas, a conceptual model of the mental path to athletic excellence was proposed from a holistic viewpoint. This model integrates five main components: personal qualities of the athlete, personal histories, mental strategies, nurturing experiences, and environmental variables.
Using Genetic Algorithms for Unsupervised Context-Free Grammar Induction
Creators: name: Partlan, Ryan James
Publisher: name: Brandeis University
Year: 2023
Subjects: context-free grammar
genetic programming
grammar induction
Artificial intelligence
Genetic Algorithms

description: Unsupervised context-free grammar (CFG) induction is a challenging task. CFGs are useful for
description: several downstream NLP tasks such as parsing, machine translation, language modeling, and dis-
description: ambiguation. There is an acute need for unsupervised methods in this domain since producing
description: corpora for supervised grammar induction is time-intensive and requires expert annotators. Fur-
description: ther, even with expert annotators the task is prone to low inter-annotator agreement. Multiple levels
description: of inter-dependent structures are discovered simultaneously. Genetic algorithms (GAs) have been
description: shown to be effective at inducing CFGs for several tasks, but applying these methods to natural
description: language corpora is still a nascent area of research. We introduce a novel method of CFG induction
description: using a GA. We augment a traditional GA approach with operations tailored for CFG induction,
description: and introduce two new methods of evaluating fitness of phrase-structure rules (PSRs) within the
description: CFG. We also experiment with several constraints motivated by results from cognitive science. We
description: show that the present method allows for efficient, parallelized induction of variable-sized CFGs.
Expression, purification and structural analysis of functional GABA transporter 1 using the baculovirus expression system
Creators: name: Hu, Jing
name: Weise, Chris
name: Boettcher, Christoph
name: Fan, Hua
name: Yin, Jian
Publisher: name: Freie Universität Berlin
Year: 2017
Subjects: subject: baculovirus expression system
subject: chromatography
subject: γ-aminobutyric acid (GABA)
subject: GABA transporter 1 (GAT1)
subject: 500 Naturwissenschaften und Mathematik::540 Chemie

description: The γ-aminobutyric acid (GABA) transporter 1 (GAT1) belongs to a family of Na+ and Cl−-coupled transport proteins and possesses 12 putative transmembrane domains. To perform structural analyses of the GAT1 protein, the GAT1/green fluorescent protein (GFP) fusion protein was functionally expressed in insect Sf9 cells by the BAC-TO-BAC® baculovirus expression system. A two-step procedure to purify the GAT1/GFP fusion protein from insect Sf9 cells has been established and involves immunoaffinity chromatography using self-prepared anti-GFP antibodies and size-exclusion fast protein liquid chromatography (SE- FPLC). A yield of 200–300 μg of the GAT1/GFP protein could be purified from 400–600 mL of infected Sf9 cells. The purified protein was analyzed by transmission electron microscopy (TEM), which revealed that the GAT1/GFP fusion protein was isolated in its monomeric form.
Deliberate practice and the acquisition of expert performance in Canadian middle-distance running.
Creators: name: Young, Bradley William.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Education, Physical.

description: The present research, comprised of two affiliated studies, specifically tested the Ericsson, Krampe, and Tesch-Romer (1993) framework for the acquisition of expertise in Canadian middle distance running. The conceptual framework posited that performance level was a monotonic function of accumulated amounts of deliberate practice. Ericsson and colleagues initially defined deliberate practice as domain-specific training activities that were highly relevant to improving performance, highly effortful in nature, and not inherently enjoyable. Study 1 tested this definition according to the runners' own perceptions of training. Contrary to the original conception of deliberate practice, results indicated that the most relevant and the most effortful training activities were also perceived as inherently enjoyable. Findings indicated that the definition for deliberate practice was not transferable from music to sport, but, rather, a modified conception of deliberate practice was required for athletics. Study 2 retrospectively compared accumulated amounts of deliberate practice between national, provincial, and club level runners across the initial nine years of their careers. Results indicated that attained performance levels were governed by a monotonic relationship with accumulated practice variables according to an inverse power law. Trends demonstrated that the national level runners began to invest more time into practice after nine years. Early in their careers, accumulated practice proved to be the primary predictor of running performance and the amount of supervised practice with a coach differentiated between the elite and club level athletes.
A novel ionizer design for detector length compensation in time-of-flight energy analysis of molecular beams
Creators: name: Wieczorek, John Lewis
Publisher: name: No Publisher Supplied
Year: 2025

description: This dissertation presents preliminary analysis of the cyclooctatetraene (COT) on Cu(001) adsorption system with angle-resolved helium atom scattering (HAS) and scanning tunneling microsopy (STM). A novel ionizer design and mass spectrometer orientation concept for time-of-flight (TOF) analysis of helium atoms is introduced. Implementation of the novel detector and optimization of TOF resolution is shown. Studies of the COT on Cu(001) adsorption system with HAS initially revealed a high-order commensurate superstructure with unit cell vectors of [6 1, 1 3] relative to the 4-fold substrate periodicity. Desorption measurements using HAS showed COT undergoes first order desorption at 570 K. Further analysis with HAS and STM at various adsorbate coverages, as well as DFT calculations, suggest that COT has one allowed adsorption site which is centered between four substrate atoms. At high coverages, COT primarily forms short-ranged ordered domains with unit cells of [3 1, 1 3] with domain boundaries of [3 0, 1 3]. The highly sensitive ionizer design achieves high TOF energy resolution with a long ionization region through a new mass spectrometer orientation and compensation of neutral arrival times of the scattered helium beam. A mass resolving quadrupole mass spectrometer orientation is reversed from the conventional sense, such that the neutral beam first passes the electron multiplier, then travels through the quadrupole region before finally passing through the ionization region. The concept is illustrated here with application to the TOF He atom detector. A carefully selected compensating variable potential curve is applied to the ionization region so that as helium progresses through the ionization region the ions are created with ever increasing ion energies. Thus, all ions from the same section of the helium beam will be detected at the same time. Compensation is also possible with high electron space charge, allowing for increased ionization efficiency through both a larger ionization volume and higher electron densities within the ionizer.
A comparative study of a stalker typology: An analysis of the stalking case files of the Ontario Provincial Police.
Creators: name: Maksymchuk, Lesa.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Psychology, Personality.

description: In 1993, the Los Angeles Police Department, with the assistance of mental health professionals, constructed a stalker typology in order to understand the elements of stalking and implement an organizational paradigm for the management of these incidents (Zona, Sharma and Lane, 1993). The purpose of this study is to assess the relevance of this typology in a Canadian context. This research study conducts a Chi-square analysis on 152 stalking case files obtained from the O.P.P. Threat Assessment Unit. The results indicate that the majority of the Ontario stalking cases were consistent with the Zona typology. For the most part, the same variables found significant in the initial study were also significant in this study. However, there were a larger number of simple obsessional stalkers. It is this group that poses the greatest threat of violence to their victims, and this result emphasizes the need for early intervention and prevention on the part of the police. (Abstract shortened by UMI.)
Glutamat-Rezeptoren und synaptische Plastizität in der lateralen Amygdala
Creators: name: Gebhardt, Christine
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: AMPA receptor
subject: NMDA receptor
subject: LTP
subject: LTD
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Synaptische Plastizität an zentralen Synapsen gilt als grundlegender Mechanismus für Lernen und Gedächtnis. Die Amygdala ist für das Furchtgedächtnis von besonderer Bedeutung. In der vorliegenden Arbeit sind einige zelluläre und molekulare Mechanismen, die der glutamatergen synaptischen Plastizität in der LA zu Grunde liegen, näher untersucht worden. Bei der NMDA-Rezeptor-abhängigen Induktion von LTP und LTD scheinen sowohl NR2A- als auch NR2B- Untereinheiten eine Rolle zu spielen. Die LTP-Expression hängt zumindest teilweise von der AMPA-Rezeptor Untereinheit GluA1 ab, während diese bei LTD-Expression nicht beteiligt zu sein scheint. Weiterhin wird die synaptische Plastizität in der LA wird durch die Aktivierung von TRP-Kanälen moduliert. Die Aktivierung von TRPV1-Rezeptoren durch Capsaicin hat eine durch die AMPA-Rezeptor Untereinheit GluA1 vermittelte Verminderung der Amplitude der LA-LTP zur Folge, während die Capsaicin-induzierte Modulation der LA-LTD durch Aktivierung von TRPM1-Rezeptoren vermittelt wird. Erstmalig wurde damit eine Funktion von TRPM1-Rezeptoren im ZNS außerhalb der Retina beschrieben.
Management of chronic spontaneous urticaria (CSU): a treat to target approach using a patient reported outcome
Creators: name: Lima, Hermenio
name: Gooderham, Melinda
name: Dutz, Jan
name: Lynde, Charles
name: Chapdelaine, Hugo
name: Ellis, Anne
name: Gilbert, Martin
name: Ho, Vincent
name: Papp, Kim
name: Poulin, Yves
name: Sussman, Gordon
Publisher: name: BioMed Central
Year: 2018

description: Background: Treat-to-target therapy approaches are established for chronic diseases such as diabetes, hypertension, and more recently rheumatoid arthritis, resulting in improved patient outcomes. These approaches do not use patient reported outcomes (PRO) as targets of therapy. Chronic spontaneous urticaria (CSU), also called chronic idiopathic urticaria (CIU), is defined as recurrent urticaria of known and unknown cause, lasting more than 6 weeks. Treatment of CSU can be challenging. However, with the advent of proven therapies and validated instruments for measuring disease activity, the concept of treat-to-target (T2T) can be successfully applied to CSU. Herein, we propose a potential PRO therapeutic target and suggest a T2T approach for the management of patients with CSU. Methods: Principles and recommendations for a treat-to-target approach in CSU (T2T/CSU) were developed by a Canadian task force, consisting of dermatologists, immunologists, and allergists. The task force formulated recommendations for therapeutic targets in CSU on the basis of a systematic literature review and expert opinion. Results: The key features of these T2T/CSU recommendations are the use of a PRO as the principal target, with symptom control as measured by Urticaria Activity Score 7 (UAS7 ≤ 6), targeting symptom remission (UAS7 = 0). Conclusion: Treatment targets such as UAS7 ≤ 6 and UAS7 = 0 provide a benchmark for success in the care of patients with CSU, and will permit the evaluation of a PRO-based T2T approach in the care of these patients and the effect of this approach on improved patient care as seen in other chronic diseases.
Aux fondements des droits humains en compagnie de Hannah Arendt.
Creators: name: Perrault, Simon.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Political Science, General.

description: Cette thèse tente d'extraire de l'oeuvre de Hannah Arendt une réponse au défi de fonder les droits humains sur des assises plus solides que la convention socio-historique sans toutefois recourir à la notion problématique de nature humaine. Dépasser la dichotomie nature-convention s'avère nécessaire à une conception des droits humains qui puisse appuyer un droit à la participation politique. La convention, qui ne renvoie à rien au-delà d'elle-même, se rend vulnérable aux soubresauts de l'histoire, dépendante qu'elle est de cette dernière. La notion (traditionnelle) de nature humaine, puisqu'elle a été située à l'intérieur de l'individu, ne peut que faire violence à l'humanité qui elle, selon Arendt, se révèle entre les individus, dans l'acte de se partager par la parole ce qui leur est commun. Notre lecture de l'oeuvre d'Arendt démontre qu'elle fait reposer les droits humains sur des droits politiques, plus particulièrement sur le droit à un espace politique qui comprend à la fois le droit aux droits de cet espace et à celui de fonder un tel espace. Il ressort de l'examen de ces droits que leur fondement se situe dans ce que Arendt nomme la natalité , c'est-à-dire la capacité de tout être humain de commencer quelque chose de nouveau.
Journal of Applied Hermeneutics, 2012
Creators: name: Journal Of Applied Hermeneutics
Publisher: name: Journal of Applied Hermeneutics
Year: 2012

description: Social Work and Hermeneutic Phenomenology
From the "Science of Disease" to the "Understanding of Those Who Suffer": The Cultivation of an Interpretive Understanding of "Behaviour Problems" in Children
Like a Melody It Passes: Dasein and Perinatal Well-being
"The Pure Guidelines of the Monastery Are to be Inscribed in Your Bones and Mind" Dogen (2010, p. 42): Mental Health Nurses'™ Practices as Ritualized Behaviour
The Hidden Nature of Death and Grief
The Descartes Lecture
Dr. David Jardine and the "Descartes Lecture": Twenty Years of Miraculous Returns
The Level Playing Field: Unconcealing Diploma Exam Accommodation Policy
In Play, At Play
The Privileges Chart in a Behaviour Class: Seeing the Power and Complexity of Dominant Traditions and Unconcealing Trust as Basic to Pedagogical Relationships
Translating God: Derrida, Ricoeur, Kearney
Learning to Live with Osteoporosis: A Metaphoric Narrative
Enlivening the Rhetoric of Family Nursing: "there, in the midst of things, his whole family listening"
"The Memories of Childhood Have No Order and No End": Pedagogical Reflections on the Occasion of the Release, on October 9th, 2009 of the Re-Mastered Version of the Beatles' Sergeant Pepper's Lonely Hearts Club Band
The role of protein kinase C in vitamin D-mediated effects in kidney.
Creators: name: Simboli-Campbell, Maura E.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1993
Subjects: subject: Chemistry, Biochemistry.

description: The role of the calcium/phospholipid-dependent serine/threonine kinase Protein Kinase C (PKC), in the effects of vitamin D on kidney was studied. Madin Darby Bovine Kidney (MDBK) cells, a normal epithelial-like cell line, were found to express the Vitamin D Receptor (VDR) and the vitamin D-dependent calcium binding protein Calbindin D-28K (CaBP D-28K). In MDBK cells, 1,25(OH)$\sb2\rm D\sb3$ increased PKC activity in a time- and dose-dependent manner as measured by two different phosphorylation assays. This activation appeared to result from translocation of PKC from the cytosol to the membrane and was accompanied by an increase in immunoreactive PKC in the membrane. PKC was also activated by short term exposure of MDBK cells to TPA, whereas PKC activity was completely down-regulated by long term exposure to TPA. Down-regulation of PKC activity was accompanied by a loss of immunoreactive PKC. The phorbol ester analogue 4$\alpha$PDD had no effect on PKC activity or amount. Concurrent with activation of PKC 1,25(OH)$\sb2\rm D\sb3$ homologously up-regulated the VDR and increased total immunoreactive CaBP D-28K in MDBK cells. In contrast, down-regulation of PKC activity in TPA treated cells was associated with decreased expression of the VDR and CaBP D-28K. The phorbol ester analogue 4$\alpha$PDD, which had no effect on PKC, did not affect the expression of the VDR or CaBP D-28K. Short term TPA treatment, which activated PKC, increased CaBP D-28K without altering VDR levels. The divergent effects of 1,25(OH)$\sb2\rm D\sb3$ and TPA were associated with differential regulation of PKC isozymes. Treatment of MDBK cells with 1,25(OH)$\sb2\rm D\sb3$ increased membrane association of PKC $\alpha,$ induced nuclear translocation of PKC $\beta$ and had no effect on PKC $\zeta.$ In contrast, long term treatment of MDBK cells with TPA induced down-regulation of PKC $\alpha,$ nuclear translocation of PKC $\beta,$ and decreased PKC $\zeta.$ Nuclear translocation of PKC $\beta$ by 1,25(OH)$\sb2\rm D\sb3$ treatment was accompanied by an increase in phosphorylation of endogenous nuclear proteins. However nuclear translocation of PKC $\beta$ by TPA treatment did not affect phosphorylation of endogenous nuclear proteins. The data have been incorporated into a model based on the hypothesis that the VDR could be a nuclear substrate for PKC $\beta$ and CaBP D-28K could be a cytosolic substrate for PKC $\alpha.$ This model predicts a novel role for PKC-dependent phosphorylations in the renal actions of 1,25(OH)$\sb2\rm D\sb3.$
Systematic Review of Cholinesterase Inhibitors on Cognition and Behavioral Symptoms in Patients of Chinese Descent with Alzheimer’s Disease, Vascular Dementia, or Mixed Dementia
Creators: name: Leung, Ka-Chun
name: Li, Victor
name: Ng, Yuey-Zhun
name: Chan, Tsz-Tai
name: Chang, Richard S.
name: Wong, Roger Y.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Cholinesterase inhibitors (ChEIs) are the primary pharmacologic treatment for dementia. Their efficacy in patients of Chinese descent is not well described. We reviewed how ChEIs could affect cognition and behavioral and psychological symptoms (BPSD) in Chinese patients with Alzheimer’s disease (AD), vascular dementia (VaD), or mixed (AD with vascular component) dementia. MEDLINE, PsycINFO, EMBASE and CINAHL were systematically searched for controlled trials of ChEIs, including donepezil, galantamine, and rivastigmine, for Chinese patients with AD, VaD, or mixed dementia. Outcomes for cognition and BPSD were extracted for discussion. Fifty-four studies were identified. While one larger study found that dementia patients of Chinese descent treated with ChEIs had significantly higher mean Mini-Mental State Examination (MMSE) score, other studies showed no significant difference. Evidence on BPSD after use of ChEIs was also conflicting. ChEIs may be effective in improving cognition among patients of Chinese descent with dementia. Further studies are needed to examine the possible effects of ChEIs on BPSD in Chinese patients with dementia in view of the small number of studies and limitations in their methodologies.
title: Evictions, income support, and health
title: examining the effects of eviction moratoriums and child tax credit on mental health and the effects of evictions on mortality
titleType: Subtitle
Creators: name: Ali, Abdinasir K.
Publisher: name: University of Iowa
Year: 2026
Subjects: Child Tax Credits
Eviction Moratoriums
Evictions
Renters
Housing
Mental Health

description: This study addresses three aims to further understand the links between housing evictions, income support, and mental health. In the first aim, the study evaluates the effects of the state eviction moratoriums enacted early during the COVID-19 pandemic on mental health of renters. In the second aim, the study assesses the impact of the expanding of the child tax credit (CTC) in the second half of 2021 on mental health separately for home renters and homeowners. And in the third aim, the study seeks to understand the associations between county-level eviction rates and eviction filing rates and county-level alcohol, drug-related, and suicide mortality. Combined, these three aims seek to examine the intersections between housing and income support as social determinants of mental health and provide evidence for two specific policies affecting housing and income support. The study uses nationally representative data from Behavioral Risk Factor Surveillance System, BRFSS for the first and second aims and Centers for Disease Control and Prevention, CDC National Vital Statistics System, and data from Princeton University Eviction lab for aim 3. The study employs regression models that address confounding through design and covariate adjustment.
description: The first study findings indicate the state eviction moratoriums early during the pandemic were associated with a mental health improvement of home renters (based on a decline in days not in good mental health in the past 30). Similarly, the second study shows that the CTC expansions were associated with improvement in mental health of home renters based on the same measure but not among homeowners with both groups selected to be within the income range that would have qualified for the maximum credit. Lastly, the third study showed little evidence of associations of evictions and filings with the mortality outcomes. Overall, the research findings suggest that increased housing security and cash transfers improve the mental vi health of low-income home renters. They also offer directions for future research on underlying mechanisms for the observed effects and further understanding of how area-level indicators of housing instability based on evictions and filing rates influence population health outcomes.
TAKODO: Integrating documents with knowledge bases for information retrieval and knowledge management.
Creators: name: Hlavina, Wratko.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Information Science.

description: The expanding availability of on-line information sources, such as on-line documents, corpora, and the World Wide Web, introduces some challenges. Most notably, users must search through this material to find high-quality, relevant information. This is the domain of information retrieval. Alternatively, knowledge bases present information in a very compact and structured representation. Unfortunately, their creation is labor intensive. In order to bridge the gap between the amount of structure in the information processed by information retrieval and knowledge engineering techniques, the author presents TAKODO, a tool and a framework designed for both (i) facilitating the extraction of knowledge from unstructured text, possibly to aid in the process of creating a knowledge base, and (ii) retrieving information from natural language texts and the knowledge base, using each to their mutual advantage. TAKODO integrates several existing applications, among them a question answering system, called Text Analyzer, and a frame-based knowledge management tool, called the Knowledge Organizer, with the additional support of corpus linguistic techniques.
An evaluation of the surveillance of communicable diseases on the island of Montserrat, West Indies.
Creators: name: Hazel, Dorothea L.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Health Sciences, Public Health.

description: This thesis evaluated the surveillance of communicable diseases on the island of Montserrat, and the island's preparedness to monitor emerging communicable diseases. The evaluation consisted of a review and assessment of the activities that make up the communicable disease surveillance system, and a survey of staff within the Ministry of Health designed to determine their level of satisfaction with surveillance and their suggestions for improvement. A survey of clinical staff was also conducted to determine their awareness of the presentations and management of two emerging diseases. The system was found to be simple, acceptable, flexible and useful. Staff reported being satisfied with most surveillance tasks. The local laboratory was found to be inadequate and the Ministry unprepared for monitoring emerging diseases. Recommendations include continuation of the existing system, development of guidelines for contact tracing and re-assessment of the role of the laboratory. Continuing education is needed for staff and patients.
title: Is fruit and vegetable intake associated with asthma or chronic rhino- sinusitis in European adults?
title: Results from the Global Allergy and Asthma Network of Excellence (GA2LEN) Survey
titleType: Subtitle
Creators: name: Garcia-Larsen, Vanessa
name: Arthur, Rhonda
name: Potts, James F.
name: Howarth, Peter H.
name: Ahlstrom, Matti
name: Haahtela, Tari
name: Loureiro, Carlos
name: Keil, Thomas
name: Matricardi, Paolo M.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Fruits
subject: Vegetables
subject: Asthma
subject: Chronic rhino-sinusitis
subject: Adults
subject: Europe
subject: Meta-analysis
subject: GA2LEN
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Fruits and vegetables are rich in compounds with proposed antioxidant, anti-allergic and anti-inflammatory properties, which could contribute to reduce the prevalence of asthma and allergic diseases. Objective We investigated the association between asthma, and chronic rhino-sinusitis (CRS) with intake of fruits and vegetables in European adults. Methods A stratified random sample was drawn from the Global Allergy and Asthma Network of Excellence (GA2LEN) screening survey, in which 55,000 adults aged 15–75 answered a questionnaire on respiratory symptoms. Asthma score (derived from self-reported asthma symptoms) and CRS were the outcomes of interest. Dietary intake of 22 subgroups of fruits and vegetables was ascertained using the internationally validated GA2LEN Food Frequency Questionnaire. Adjusted associations were examined with negative binomial and multiple regressions. Simes procedure was used to control for multiple testing. Results A total of 3206 individuals had valid data on asthma and dietary exposures of interest. 22.8% reported having at least 1 asthma symptom (asthma score ≥1), whilst 19.5% had CRS. After adjustment for potential confounders, asthma score was negatively associated with intake of dried fruits (β-coefficient −2.34; 95% confidence interval [CI] −4.09, −0.59), whilst CRS was statistically negatively associated with total intake of fruits (OR 0.73; 95% CI 0.55, 0.97). Conversely, a positive association was observed between asthma score and alliums vegetables (adjusted β-coefficient 0.23; 95% CI 0.06, 0.40). None of these associations remained statistically significant after controlling for multiple testing. Conclusion and clinical relevance There was no consistent evidence for an association of asthma or CRS with fruit and vegetable intake in this representative sample of European adults.
Eyewitness Identification Evidence and Improving Legal Safeguards
Creators: name: Skalon, Alena
Publisher: name: Swinburne
Year: 2024

description: This thesis aimed to establish the effectiveness of traditional legal safeguards and of an innovative educational aid in sensitising mock-jurors to the quality of identification procedures and to eyewitness identification accuracy. Taken together, my studies suggested that neither of the traditional legal safeguards effectively improved mock-jurors' decisions. The new educational aid led to overbelief. The most consistent finding of this thesis was that mock-jurors were sensitive to identification accuracy when identification procedures were non-suggestive. Concerningly, this sensitivity was lost when identification procedures were suggestive. This highlights the importance of using best practice procedures when obtaining eyewitness evidence.
Dynamics-based linearization and control of an autonomous ground vehicle.
Creators: name: Eghtesad, Mohammad.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Engineering, Mechanical.

description: Several aspects of dynamics based motion control of autonomous ground vehicles have been studied. For example kinematic and dynamic modelling of the vehicle, path and motion planning, path following and trajectory tracking, stabilization to a manifold and a to a desired position with specified orientation have been considered. Assuming the (ideal) rolling without slipping conditions for a wheel imposes the nonholonomic (non-integrable) constraints on the motion of the wheel and the vehicle. Nonholonomic systems are found not to be asymptotically stabilizable by a smooth state feedback laws. In this research, first, kinematics and Newtonian dynamics of a tricycle with front wheel steering and driving are developed and then using the concepts of Lagrange equations of the first kind, the dynamic models of the tricycle in the form of x = f(x,u) with torque inputs are derived. Nonlinear control theory and input-output feedback linearization as a systematic approach have been applied on these dynamic models of the vehicle. Cartesian space feedback linearization is utilized for trajectory tracking and asymptotic stabilization to a one dimensional manifold and simulation results are provided. Curvilinear space feedback linearization approach for asymptotic stabilization of two outputs with open-loop control of the third planar variable using a planned path between two end positions and orientations has been verified by simulations and implemented on an experimental setup. Internal dynamics of the system has been investigated, and its dimension, state variable and stability have been analysed.
Comparison of the Gini and Zenga indexes using some theoretical income distributions
Creators: name: OSTASIEWICZ, Katarzyna
name: MAZUREK, Edyta
Publisher: name: Wrocław University of Technology, Wrocław University of Economics, Polish Operational and Systems Research Society
Year: 2013
Subjects: inequality, Gini index, Zenga index

description: OPERATIONS RESEARCH AND DECISIONS; ISSN 2081-8858
title: Whole-body vibration to prevent intensive care unit-acquired weakness
title: safety, feasibility, and metabolic response
titleType: Subtitle
Creators: name: Wollersheim, Tobias
name: Haas, Kurt
name: Wolf, Stefan
name: Mai, Knut
name: Spies, Claudia
name: Steinhagen-Thiessen, Elisabeth
name: Wernecke, Klaus-D.
name: Spranger, Joachim
name: Weber-Carstens, Steffen
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Intensive care unit-acquired weakness
subject: Physiotherapy
subject: Whole-body
subject: vibration
subject: Mobilization
subject: Muscle wasting
subject: Metabolism
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Intensive care unit (ICU)-acquired weakness in critically ill patients is a common and significant complication affecting the course of critical illness. Whole-body vibration is known to be effective muscle training and may be an option in diminishing weakness and muscle wasting. Especially, patients who are immobilized and not available for active physiotherapy may benefit. Until now whole-body vibration was not investigated in mechanically ventilated ICU patients. We investigated the safety, feasibility, and metabolic response of whole-body vibration in critically ill patients. Methods We investigated 19 mechanically ventilated, immobilized ICU patients. Passive range of motion was performed prior to whole-body vibration therapy held in the supine position for 15 minutes. Continuous monitoring of vital signs, hemodynamics, and energy metabolism, as well as intermittent blood sampling, took place from the start of baseline measurements up to 1 hour post intervention. We performed comparative longitudinal analysis of the phases before, during, and after intervention. Results Vital signs and hemodynamic parameters remained stable with only minor changes resulting from the intervention. No application had to be interrupted. We did not observe any adverse event. Whole-body vibration did not significantly and/or clinically change vital signs and hemodynamics. A significant increase in energy expenditure during whole-body vibration could be observed. Conclusions In our study the application of whole-body vibration was safe and feasible. The technique leads to increased energy expenditure. This may offer the chance to treat patients in the ICU with whole-body vibration. Further investigations should focus on the efficacy of whole-body vibration in the prevention of ICU- acquired weakness. Trial registration Applicability and Safety of Vibration Therapy in Intensive Care Unit (ICU) Patients. ClinicalTrials.gov NCT01286610. Registered 28 January 2011.
Characterization of the DNA-independent dimerization interface of the rat glucocorticoid receptor.
Creators: name: Savory, Joanne G. Allison.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Biology, Molecular.

description: The glucocorticoid receptor (GR), a member of the nuclear receptor superfamily of transcription factors, binds DNA as a ligand induced homodimer. Within the DNA binding domain, a short sequence of amino acids called the D-box, has been shown by mutagenesis and structural studies to function as a DNA-dependent dimerization interface. The importance of the D-box for DNA-dependent dimerization by GR is well known. A second dimerization activity necessary for dimerization in solution in the absence of DNA has been proposed for GP, based on homology with other steroid receptors. While the DNA-dependent dimerization, activity has been extensively studied, very little is known about the DNA-independent dimerization activity in GR. The subject of this thesis is the characterization of the solution dimerization activity in GR. Three independent assays demonstrated solution dimerization of GR: co-immunoprecipitation, GST pull-down and two-hybrid assay in yeast. The GR, in its steroid free state, is packaged into a heat shock protein containing multiprotein complex. My results showed that solution dimerization of GR required dissociation of the heat shock protein complex. However, dimerization did not appear to have a strict ligand requirement as efficient dimerization occurred with both salt- and antagonist-treated receptors. Further, by all three assays, I show that amino acids 505 to 547 are required for GR solution dimerization. Interestingly, these amino acids overlap with the nuclear localization signal-1 in GR, the binding site for the NLS receptor importin alpha. Additionally, my data also provided evidence for protein interaction surfaces in the amino and carboxy terminal domains of GR, results that are consistent with the idea that multiple regions of GR contribute, either directly or indirectly, to homodimerization. Co-transfection experiments with wild type GR and a GR mutant, which had a mutation in one of its nuclear localization signals such that it was unable to efficiently transfer to the nucleus in response to hormone, demonstrated an interaction between full-length GR monomers in vivo. Data from the co-transfection assay also suggested that GR homodimerizes in the cytoplasm prior to nuclear import. Finally, I show for the first time that GR has the potential to heterodimerize with several members of the nuclear receptor superfamily in solution. These results provide the first detailed characterization of the GR solution dimerization activity.
Health policy and systems research collaboration pathways: lessons from a network science analysis
Creators: name: English, Krista M
name: Pourbohloul, Babak
Publisher: name: BioMed Central
Year: 2017

description: Background: The 2004 Mexico Declaration, and subsequent World Health Assembly resolutions, proposed a concerted support for the global development of health policy and systems research (HPSR). This included coordination across partners and advocates for the field of HPSR to monitor the development of the field, while promoting decision-making power and implementing responsibilities in low- and middle-income countries (LMICs). Methods: We used a network science approach to examine the structural properties of the HPSR co-authorship network across country economic groups in the PubMed citation database from 1990 to 2015. This analysis summarises the evolution of the publication, co-authorship and citation networks within HPSR. Results: This method allows identification of several features otherwise not apparent. The co-authorship network has evolved steadily from 1990 to 2015 in terms of number of publications, but more importantly, in terms of co-authorship network connectedness. Our analysis suggests that, despite growth in the contribution from low-income countries to HPSR literature, co-authorship remains highly localised. Lower middle-income countries have made progress toward global connectivity through diversified collaboration with various institutions and regions. Global connectivity of the upper middle-income countries (UpperMICs) are almost on par with high-income countries (HICs), indicating the transition of this group of countries toward becoming major contributors to the field. Conclusions: Network analysis allows examination of the connectedness among the HSPR community. Initially (early 1990s), research groups operated almost exclusively independently and, despite the topic being specifically on health policy in LMICs, HICs provided lead authorship. Since the early 1990s, the network has evolved significantly. In the full set analysis (1990–2015), for the first time in HPSR history, more than half of the authors are connected and lead authorship from UpperMICs is on par with that of HICs. This demonstrates the shift in participation and influence toward regions which HPSR primarily serves. Understanding these interactions can highlight the current strengths and future opportunities for identifying new strategies to enhance collaboration and support capacity-building efforts for HPSR.