cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A Network Integration Approach to Predict Conserved Regulators Related to Pathogenicity of Influenza and SARS-CoV Respiratory Viruses
Creators: name: Tchitchek, Nicolas
name: Benecke, Arndt G.
name: Shukla, Anil K.
name: Chang, Jean H.
name: McDermott, Jason E.
name: Sims, Amy C.
name: Smith, Richard D.
name: Heegel, Robert A.
name: Matzke, Melissa M.
name: Schepmoes, Athena A.
name: Josset, Laurence
name: Neumann, Gabriele
name: Kawaoka, Yoshihiro
name: Waters, Katrina M.
name: Tilton, Susan C.
name: Luna, Maria L.
name: Ellis, Amy L.
name: Baric, Ralph S.
name: Mitchell, Hugh D.
name: Li, Chengjun
name: Eisfeld, Amie J.
name: Webb-Robertson, Bobbi-Jo M.
name: Metz, Thomas O.
name: Katze, Michael G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Respiratory infections stemming from influenza viruses and the Severe Acute Respiratory Syndrome corona virus (SARS-CoV) represent a serious public health threat as emerging pandemics. Despite efforts to identify the critical interactions of these viruses with host machinery, the key regulatory events that lead to disease pathology remain poorly targeted with therapeutics. Here we implement an integrated network interrogation approach, in which proteome and transcriptome datasets from infection of both viruses in human lung epithelial cells are utilized to predict regulatory genes involved in the host response. We take advantage of a novel "crowd-based" approach to identify and combine ranking metrics that isolate genes/proteins likely related to the pathogenicity of SARS-CoV and influenza virus. Subsequently, a multivariate regression model is used to compare predicted lung epithelial regulatory influences with data derived from other respiratory virus infection models. We predicted a small set of regulatory factors with conserved behavior for consideration as important components of viral pathogenesis that might also serve as therapeutic targets for intervention. Our results demonstrate the utility of integrating diverse 'omic datasets to predict and prioritize regulatory features conserved across multiple pathogen infection models.
Gisbert Greshake (Hrsg.), Zur Frage der Bischofsernennungen in der römisch-katholischen Kirche
Publisher: name: Herder Korrespondenz
Year: 1970

description: Herder Korrespondenz, Bd. 45 Nr. 7 (1991): Herder Korrespondenz, Band 45, Heft 7
title: Normal myelination: a practical pictorial review
Creators: name: Gaha, Mehdi
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Neuroradiology brain
subject: Anatomy
subject: MR
subject: MR-Diffusion/Perfusion
subject: MR-Spectroscopy
subject: Diagnostic procedure
subject: Education
subject: Congenital
subject: Foetus

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The MRI techniques that have evolved for the assessment of cerebral myelination will be reviewed. This will be followed by a discussion of both general myelination patterns as well as age-related milestones in myelin development. Finally, we...
Classical resolution of black hole singularities in arbitrary dimension
Creators: name: Bazeia, D.
name: Losano, L.
name: Olmo, Gonzalo J.
name: Rubiera-Garcia, D.
name: Sanchez-Puente, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: A metric-affine approach is employed to study higher-dimensional modified gravity theories involving different powers and contractions of the Ricci tensor. It is shown that the field equations are \emph{always} second-order, as opposed to the standard metric approach, where this is only achieved for Lagrangians of the Lovelock type. We point out that this property might have relevant implications for the AdS/CFT correspondence in black hole scenarios. We illustrate these aspects by considering the case of Born-Infeld gravity in $d$ dimensions, where we work out exact solutions for electrovacuum configurations. Our results put forward that black hole singularities in arbitrary dimensions can be cured in a purely classical geometric scenario governed by second-order field equations.
description: 14 pages, 2 figures, to appear in PRD
COVID-DYNAMIC. Characterizing the dynamics of emotional and social attitudes during the COVID-19 pandemic
Creators: name: Lin, Chujun
name: Adolphs, Ralph
name: Stanley, Damian
name: Alvarez, R.
name: Maoz, Uri
name: Paul, Lynn
name: Han, Yanting
name: Rusch, Tessa
name: Lan, Tian
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences
subject: Covid-19
subject: decision-making
subject: explicit emotional biases
subject: implicit emotional biases
subject: longitudinal study
subject: moral judgments
subject: political judgments

description: This project is conducted by the COVID-DYNAMIC Team (http://conte.caltech.edu/content/covid-dynamic-investigator-team) The COVID-19 pandemic is confronting people with significant changes in affectively-laden media exposure as well as in social behavior. To quantify longitudinal effects that could inform public health policy, we will collect anonymized data over the internet on subject's implicit and explicit emotional biases, and characterize how these might relate to social, economic, moral and political judgments and decision-making. We will sample approximately 1000 English-speaking adult participants in the US over the internet anonymously, recruited through Prolific.co. We will also sample an extant registry of approximately 100 community-dwelling adults in Los Angeles that are part of the Caltech Conte Center on the Neurobiology of Social Decision-Making (http://conte.caltech.edu/content/covid-dynamic). We plan to test participants longitudinally for approximately one hour, up to one year. We expect that the frequency of testing will vary depending on the development of the pandemic, from weekly to monthly. Subject recruitment and testing began on April 5, 2020, with additional waves re-tested in the subsequent two weeks, and data collection ongoing. At this point, we have only analyzed the data from these three waves for quality control and instrument design purposes, but have not analyzed any data for any hypothesis testing. This preregistration includes methods of participant recruitment, sample size, inclusion and exclusion criteria, and general study procedures. Subsequent preregistrations will provide updates and cover specific studies that we will conduct using the data collected with the procedures described here.
title: All clogged up: Spectrum of venous thrombosis in the abdomen and pelvis.
Creators: name: Zalaquett, Eugenio
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Embolism / Thrombosis
subject: Thrombolysis
subject: Ultrasound
subject: MR
subject: CT
subject: Veins / Vena cava
subject: Pelvis
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: 1. To understand the pathophysiology of venous outflow obstruction in the abdomen and pelvis and its clinical implications. 2. To review the different thrombus types and their most common causes in the abdomen and pelvis. 3. To illustrate the...
Existing recommendations or guidelines regarding the process of stakeholder identification specific to human resources for health and health workforce development: a scoping review protocol.
Creators: name: North, Natasha
name: Brysiewicz, Petra
name: Coetzee, Minette
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: guidelines
subject: human resources for health
subject: JBI
subject: nursing
subject: Scoping review protocol
subject: stakeholder
subject: stakeholder engagement

description: Scoping review protocol
MyD88 Is Required for Protection from Lethal Infection with a Mouse-Adapted SARS-CoV
Creators: name: Funkhouser, William
name: Morrison, Thomas E.
name: Heise, Mark T.
name: Sheahan, Timothy
name: Uematsu, Satoshi
name: Baric, Ralph S.
name: Akira, Shizou
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: A novel human coronavirus, SARS-CoV, emerged suddenly in 2003, causing approximately 8000 human cases and more than 700 deaths worldwide. Since most animal models fail to faithfully recapitulate the clinical course of SARS-CoV in humans, the virus and host factors that mediate disease pathogenesis remain unclear. Recently, our laboratory and others developed a recombinant mouse-adapted SARS-CoV (rMA15) that was lethal in BALB/c mice. In contrast, intranasal infection of young 10-week-old C57BL/6 mice with rMA15 results in a nonlethal infection characterized by high titer replication within the lungs, lung inflammation, destruction of lung tissue, and loss of body weight, thus providing a useful model to identify host mediators of protection. Here, we report that mice deficient in MyD88 (MyD88−/−), an adapter protein that mediates Toll-like receptor (TLR), IL-1R, and IL-18R signaling, are far more susceptible to rMA15 infection. The genetic absence of MyD88 resulted in enhanced pulmonary pathology and greater than 90% mortality by day 6 post-infection. MyD88−/− mice had significantly higher viral loads in lung tissue throughout the course of infection. Despite increased viral loads, the expression of multiple proinflammatory cytokines and chemokines within lung tissue and recruitment of inflammatory monocytes/macrophages to the lung was severely impaired in MyD88−/− mice compared to wild-type mice. Furthermore, mice deficient in chemokine receptors that contribute to monocyte recruitment to the lung were more susceptible to rMA15-induced disease and exhibited severe lung pathology similar to that seen in MyD88−/−mice. These data suggest that MyD88-mediated innate immune signaling and inflammatory cell recruitment to the lung are required for protection from lethal rMA15 infection.
Halo orbits around the collinear points of the restricted three-body problem
Creators: name: Ceccaroni, Marta
name: Celletti, Alessandra
name: Pucacco, Giuseppe
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: We perform an analytical study of the bifurcation of the halo orbits around the collinear points $L_1$, $L_2$, $L_3$ for the circular, spatial, restricted three--body problem. Following a standard procedure, we reduce to the center manifold constructing a normal form adapted to the synchronous resonance. Introducing a detuning, which measures the displacement from the resonance and expanding the energy in series of the detuning, we are able to evaluate the energy level at which the bifurcation takes place for arbitrary values of the mass ratio. In most cases, the analytical results thus obtained are in very good agreement with the numerical expectations, providing the bifurcation threshold with good accuracy. Care must be taken when dealing with $L_3$ for small values of the mass-ratio between the primaries; in that case, the model of the system is a singular perturbation problem and the normal form method is not particularly suited to evaluate the bifurcation threshold.
description: 35 pages, 3 figures, updated version accepted for publication on Physica D
Kurt Waldmann, Die Knochenfunde aus der Colonia Ulpia Traiana, einer römischen Stadt bei Xanten am Niederrhein
Creators: name: Reichstein, Hans
Publisher: name: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts
Year: 2023

description: Kurt Waldmann, Die Knochenfunde aus der Colonia Ulpia Traiana, einer römischen Stadt bei Xanten am Niederrhein. Archao-Physika 3. Beihefte der Bonner Jahrbücher, Band 24. Böhlau Verlag, Köln-Graz 1967. 79 Tab., 5 Diagramme und 7 Tafeln.
description: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts, Bd. 48 (1970)
A Topological Obstruction to the Removal of a Degenerate Complex Tangent and Some Related Homotopy and Homology Groups
Creators: name: Elgindi, Ali M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Complex Variables (math.CV)
subject: Geometric Topology (math.GT)
subject: FOS: Mathematics

description: In this article, we derive a topological obstruction to the removal of a isolated degenerate complex tangent to an embedding of a 3-manifold into $\mathbb{C}^3$ (without affecting the structure of the remaining complex tangents). We demonstrate how the vanishing of this obstruction is both a necessary and sufficient condition for the (local) removal of the isolated complex tangent. The obstruction is a certain homotopy class of the space $\mathbb{Y}$ consisting of totally real 3-planes in the Grassmanian of real 3-planes in $\mathbb{C}^3$ (=$\mathbb{R}^6$). We further compute additional homotopy and homology groups for the space $\mathbb{Y}$ and of its complement $\mathbb{W}$ consisting of "partially complex" 3-planes in $\mathbb{C}^3$.
description: Formal version has been published
title: A cross-sectional analysis to assess newly graduated doctors’ ability to identify appropriate radiological investigations
Creators: name: Moloney, Brian
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Education and training
subject: Education
subject: Ultrasound
subject: MR
subject: CT
subject: Professional issues
subject: Management

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The purpose of our educational exhibit is to: Compare the abilities of a goup of students at the start of their final year of undergraduate medicine education with a group of students who had completed their final year of undergraduate medical...
Replication
Creators: name: O'Madagain, Cathal
Publisher: name: Open Science Framework
Year: 2022

description: We ran a preregistered replication of our study. We tested the same 4 vignettes used in the original study and also 8 new ones. The tendency to expect the agent to prefer the bad motive did not replicate in overall, but it did replicate in the original four vignettes. However, we also found that participants treated the 'good motives' as more extreme than the bad motives in the new vignettes, which may explain why the tendency to pick the bad motives in the original vignettes did not occur again. You can find the data and rscript for our analysis on this page. Here is the preregistration: https://osf.io/9djav
title: A step by step guide to stereotactic - vacuum assisted breast biopsy
Creators: name: Morales, Alinne
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Cancer
subject: Vacuum assisted biopsy
subject: Mammography
subject: Breast

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To describe step by step stereotactic- vacuum assisted breast biopsy (VABB) technique using pictures and illustrations schemes with didactic purpose. To review the current indications, limitations and the most common complications for this...
Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing
Creators: name: Baric, Ralph S.
name: Eckerle, Lance D.
name: Scherbakova, Sana
name: Venter, Eli
name: Denison, Mark R.
name: Graham, Rachel L.
name: Lu, Xiaotao
name: Spiro, David J.
name: Li, Kelvin
name: Becker, Michelle M.
name: Halpin, Rebecca A.
name: Stockwell, Timothy B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Most RNA viruses lack the mechanisms to recognize and correct mutations that arise during genome replication, resulting in quasispecies diversity that is required for pathogenesis and adaptation. However, it is not known how viruses encoding large viral RNA genomes such as the Coronaviridae (26 to 32 kb) balance the requirements for genome stability and quasispecies diversity. Further, the limits of replication infidelity during replication of large RNA genomes and how decreased fidelity impacts virus fitness over time are not known. Our previous work demonstrated that genetic inactivation of the coronavirus exoribonuclease (ExoN) in nonstructural protein 14 (nsp14) of murine hepatitis virus results in a 15-fold decrease in replication fidelity. However, it is not known whether nsp14-ExoN is required for replication fidelity of all coronaviruses, nor the impact of decreased fidelity on genome diversity and fitness during replication and passage. We report here the engineering and recovery of nsp14-ExoN mutant viruses of severe acute respiratory syndrome coronavirus (SARS-CoV) that have stable growth defects and demonstrate a 21-fold increase in mutation frequency during replication in culture. Analysis of complete genome sequences from SARS-ExoN mutant viral clones revealed unique mutation sets in every genome examined from the same round of replication and a total of 100 unique mutations across the genome. Using novel bioinformatic tools and deep sequencing across the full-length genome following 10 population passages in vitro, we demonstrate retention of ExoN mutations and continued increased diversity and mutational load compared to wild-type SARS-CoV. The results define a novel genetic and bioinformatics model for introduction and identification of multi-allelic mutations in replication competent viruses that will be powerful tools for testing the effects of decreased fidelity and increased quasispecies diversity on viral replication, pathogenesis, and evolution.
title: Computed tomography colonography without insufflation in the emergency setting: role in the assessment and in the surgical planning of intestinal volvulus
Creators: name: Del Prato, Alberto
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Gastrointestinal tract
subject: CT
subject: Diagnostic procedure
subject: Volvulus

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: CT-colonography is currently proposed as the radiological investigation of choice in the context of colorectal neoplasia by the European Society of Gastrointestinal and Abdominal Radiology (ESGAR) and the European Society of Gastrointestinal...
Introducing genre-based pedagogy to the teaching of literature reviews in an Indonesian EFL context
Creators: name: Afifi, Nur
Publisher: name: Macquarie University
Year: 2023
Subjects: classificationCode: 399999
subject: Other education not elsewhere classified

description: This thesis reports on a classroom-based action research project, involving the teaching of literature reviews in an Indonesian EFL context. A genre-based curriculum was developed, based on a ‘pedagogical genre’ of literature reviews and the pedagogical approach widely known as the teaching learning cycle as developed in systemic functional linguistics. Evidence from the initial teaching implementation showed that students found the course useful, and a number developed the ability to write literature reviews as taught during the twelve meetings of the program. However, the study also found that the problematic writing practices that had served as motivation for the intervention persisted among the cohort at the end of the curriculum, and the students needed more support in terms of the lexicogrammar and discourse semantics of literature reviews. Therefore, additional analysis focusing on the discursive features of the literature review model texts was conducted in order to inform a more comprehensive framework for the teaching of the linguistic resources needed for literature review writing. This thesis presents the results of the analysis of student and teacher perceptions of academic writing, the development of a pedagogical genre for the teaching of literature reviews, the design and implementation of a curriculum for the teaching of literature reviews in a tertiary Indonesian EFL context, and an analysis of the discursive features of literature reviews. This represents a significant period in an ongoing action research cycle, where language-curriculum development and implementation is informed by research into the target texts of learners.
Data from: Causal evidence for the adaptive benefits of social foraging in the wild
Creators: name: Snijders, Lysanne
name: Krause, Stefan
name: Tump, Alan
name: Breuker, Michael
name: Ortiz, Chente
name: Rizzi, Sofia
name: Ramnarine, Indar
name: Krause, Jens
name: Kurvers, Ralf
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Evolution
subject: Behavior and Ethology
subject: Life Sciences
subject: Ecology and Evolutionary Biology
subject: Biology
subject: Zoology
subject: FOS: Biological sciences
subject: Terrestrial and Aquatic Ecology
subject: Animal Sciences
subject: Aquaculture and Fisheries Life Sciences
subject: Freshwater ecology
subject: Group size
subject: Guppy
subject: Poecilia reticulata
subject: Social evolution
subject: Social facilitation
subject: Social foraging
subject: Social information use
subject: Sociality

description: Sociality is a fundamental organizing principle across taxa, thought to come with a suite of adaptive benefits. However, making causal inferences about these adaptive benefits requires experimental manipulation of the social environment, which is rarely feasible in the field. Here we manipulated the number of conspecifics in Trinidadian guppies (Poecilia reticulata) in the wild, and quantified how this affected a key benefit of sociality, social foraging, by investigating several components of foraging success. As adaptive benefits of social foraging may differ between sexes, we studied males and females separately, expecting females, the more social and risk-averse sex, to benefit more from conspecifics than males. Conducting over 1,600 foraging trials, we found that in both sexes, increasing the number of conspecifics led to faster detection of novel food patches and a higher probability of feeding following detection of the patch, resulting in greater individual resource consumption. The slope of the latter relationship differed between the sexes, with males unexpectedly exhibiting a stronger social benefit. Our study provides rare causal evidence for the adaptive benefits of social foraging in the wild, and highlights that sex differences in sociality do not necessarily imply an unequal ability to profit from the presence of others.
Wir Menschen der Zukunft?
Creators: name: Meurer-Bongardt, Judith
Publisher: name: Humboldt-Universität zu Berlin
Year: 2018
Subjects: subject: Skandinavien
subject: Nordeuropa
subject: Literatur
subject: Dystopie
subject: Heterotopie
subject: Identitäten
subject: Europe
subject: Literature
subject: Identities
subject: 839 Andere germanische Literaturen

description: Im ersten Teil des Beitrags wird eine Zusammenführung der Begriffe »Utopie« und »Biopolitik« aus historischer und theoretischer Perspektive versucht. Es werden zudem zwei Begriff eingeführt, die »Heterotopie« und die »Figur des Dritten«, anhand derer im zweiten Teil gezeigt wird, wie es aktuellen Utopien / Dystopien gelingt, die eigene Zeit nicht nur kritisch zu beleuchten, sondern auch positives Zukunftspotenzial freizulegen. Im Mittelpunkt des zweiten Teils steht eine Auswahl von Texten, die als beispielhaft für das in den letzten Jahren im Norden populäre Genre des utopischen / dystopischen Romans verstanden werden kann, und anhand derer deutlich wird, welche Rolle Biopolitik in dieser Gattung spielt.
description: In the first part of this article the concept of utopia and the field of bio-politics are brought together from a historical and a theoretical perspective. In addition to that, two terms are discussed: »heterotopia« and »the figure of the third«. With help of these terms, it is possible to show how recent utopian / dystopian literature succeeds not only to criticise its own time but also to reveal a positive potential for the future. In the second part I focus on a choice of texts which can be seen as good examples for the genre of utopia / dystopia that is popular in recent Nordic literature. Furthermore, these texts are useful in giving an impression of the relevance of bio-politics for this literary genre.
Education for Human Capacity Building: Achievements and Shortcomings in the Ethiopian Experience
Creators: name: Fasika Chekol
Publisher: name: Zenodo
Year: 2024

description: The study has examined the reasons behind the delinking of education and economic development in Ethiopia. The growth of the economy was declining over time due to the growth of unemployment and underemployments of the educated labor force. For this, the misdirected education system was a major factor for the production of unskilled labor force that couldn’t be productive and job creator. Of which the Poor enrolment of vocational courses, method of delivery, absence of relevant inputs, absence of industrial linkage as well as the existence of unskilled teachers were the main determinants affecting the quality of education system. In addition, the development of the Ethiopian Educational Road-Map does not also review the relevance of education outcome which is similar to the existing education system. Taking into consideration the human capacity building, the ministry of education should revise the education Road-Map urgently.
Gravitational lensing by Reissner-Nordström black holes with topological defects
Creators: name: Jusufi, Kimet
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Using a new geometrical approach introduced by Gibbons and Werner we study the deflection angle by Reissner-Nordström black holes in the background spacetimes with a global monopole and a cosmic string. By calculating the corresponding optical Gaussian curvature and applying the Gauss-Bonnet theorem to the optical metric we find the leading terms of the deflection angle in the weak limit approximation. We find that the deflection angle increases due to the presence of topological defects.
description: 8 pages, revised version, accepted for publication in Astrophysics and Space Science
title: Spiral flow tube in coronary CT angiography for contrast dose reduction with maintained enhancement and diagnostic performance
Creators: name: Tomizawa, Nobuo
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Outcomes
subject: Contrast agent-intravenous
subject: CT-Angiography
subject: Cardiac

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Saline flush is an established method in coronary CT angiography to wash out the dense contrast medium from the right ventricular system and increase the enhancement of coronary arteries [1]. A T-shaped tube (Fig 1a) is widely used for saline flush...
SARS-CoV Pathogenesis Is Regulated by a STAT1 Dependent but a Type I, II and III Interferon Receptor Independent Mechanism
Creators: name: Frieman, Matthew
name: Baric, Ralph S.
name: Lamirande, Elaine W.
name: Chen, Jun
name: Heise, Mark
name: Morrison, Thomas E.
name: Roberts, Anjeanette
name: Whitmore, Alan
name: Ward, Jerrold M.
name: Funkhouser, William
name: Subbarao, Kanta
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Severe acute respiratory syndrome coronavirus (SARS-CoV) infection often caused severe end stage lung disease and organizing phase diffuse alveolar damage, especially in the elderly. The virus-host interactions that governed development of these acute end stage lung diseases and death are unknown. To address this question, we evaluated the role of innate immune signaling in protection from human (Urbani) and a recombinant mouse adapted SARS-CoV, designated rMA15. In contrast to most models of viral pathogenesis, infection of type I, type II or type III interferon knockout mice (129 background) with either Urbani or MA15 viruses resulted in clinical disease outcomes, including transient weight loss, denuding bronchiolitis and alveolar inflammation and recovery, identical to that seen in infection of wildtype mice. This suggests that type I, II and III interferon signaling play minor roles in regulating SARS pathogenesis in mouse models. In contrast, infection of STAT1−/− mice resulted in severe disease, high virus titer, extensive pulmonary lesions and 100% mortality by day 9 and 30 post-infection with rMA15 or Urbani viruses, respectively. Non-lethal in BALB/c mice, Urbani SARS-CoV infection in STAT1−/− mice caused disseminated infection involving the liver, spleen and other tissues after day 9. These findings demonstrated that SARS-CoV pathogenesis is regulated by a STAT1 dependent but type I, II and III interferon receptor independent, mechanism. In contrast to a well documented role in innate immunity, we propose that STAT1 also protects mice via its role as an antagonist of unrestrained cell proliferation.
Studien zu den Militärgrenzen Roms
Creators: name: Simon, Hans-Günther
Publisher: name: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts
Year: 2023

description: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts, Bd. 48 (1970)
CCD polarimetry of distant comets C/2010 S1 (LINEAR) and C/2010 R1 (LINEAR) at the 6-m telescope of the SAO RAS
Creators: name: Ivanova, Oleksandra V.
name: Dlugach, Janna M.
name: Afanasiev, Viktor L.
name: Reshetnyk, Volodymyr M.
name: Korsun, Pavlo P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We present first measurements of the degree of linear polarization of distant comets C/2010 S1 (LINEAR) and C/2010 R1 (LINEAR) at heliocentric distances r= 5.9 - 7.0 AU. Observations were carried out with the SCORPIO-2 focal reducer at the 6-m telescope of the SAO RAS. Both comets showed considerable level of activity beyond a zone where water ice sublimation is negligible (up to 5 AU). Significant spatial variations both in the intensity and polarization are found in both comets. The slope of radial profiles of intensity changes gradually with the distance from the photocenter: from - 0.7 near the nucleus up to about - 1.3 for larger distances (up to 100000 km). The variation in polarization profiles indicates the non uniformity in the polarization distribution over the coma. The polarization degree over the coma gradually increases (in absolute value) with increasing the photocentric distance from of about - 1.9% up to - 3% for comet C/2010 S1 (LINEAR), and from of about - 2.5% up to - 3.5% for comet C/2010 R1 (LINEAR). These polarization values are significantly higher than typical value of the whole coma polarization (-1.5%) for comets at heliocentric distances less than 5 AU. The obtained photometric and polarimetric data are compared with those derived early for other comets at smaller heliocentric distances. Numerical modeling of light scattering characteristics was performed for media composed of particles with different refractive index, shape, and size. The computations were made by using the superposition T-matrix method. We obtained that for comet C/2010 S1 (LINEAR), the dust in the form of aggregates of overall radius R ~ 1.3 μm composed of N = 1000 spherical monomers with radius a = 0.1 μm, refractive index m = 1.65 + i 0.05, allows to obtain a satisfactory agreement between the results of polarimetric observations of comet C/2010 S1 and computations.
description: 28 pages, 13 figures
Conceptualizing irremediable psychiatric suffering to the background of physician assisted death with a Delphi-study
Creators: name: van Veen, Sisco
name: Widdershoven, G.A.M.
name: Vandenberghe, J.
name: Beekman, A.
name: Evans, Natalie
name: Ruissen, A.
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Psychiatry and Psychology
subject: Medicine and Health Sciences
subject: Medical Specialties
subject: Bioethics and Medical Ethics
subject: Psychiatry
subject: Delphi
subject: Empirical ethics
subject: End of life
subject: Ethics
subject: Euthanasia
subject: Futility
subject: Irremediability
subject: MAID
subject: Medical Assistance in Dying
subject: PAD
subject: Physician assisted Death
subject: Psychiatric suffering
subject: Psychiatry

description: A modified Delphi study that aims to find consensus- criteria for irremediable psychiatric suffering in the context of PAD.
A new mouse-adapted strain of SARS-CoV as a lethal model for evaluating antiviral agents in vitro and in vivo
Creators: name: Barnard, Dale L.
name: Morrey, John D.
name: Kumaki, Yohichi
name: Baric, Ralph
name: Day, Craig W.
name: Cai, Sui Xiong
name: Frieman, Matthew
name: Smee, Donald F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Severe acute respiratory syndrome (SARS) is a highly lethal emerging disease caused by coronavirus SARS-CoV. New lethal animal models for SARS were needed to facilitate antiviral research. We adapted and characterized a new strain of SARS-CoV (strain v2163) that was highly lethal in 5–6 week old BALB/c mice. It had nine mutations affecting 10 amino acid residues. Strain v2163 increased IL-1α, IL-6, MIP-1α, MCP-1, and RANTES in mice, and high IL-6 expression correlated with mortality. The infection largely mimicked human disease, but lung pathology lacked hyaline membrane formation. In vitro efficacy against v2163 was shown with known inhihibitors of SARS-CoV replication. In v2163-infected mice, Ampligen™ was fully protective, stinging nettle lectin (UDA) was partially protective, ribavirin was disputable and possibly exacerbated disease, and {"type":"entrez-nucleotide","attrs":{"text":"EP128533","term_id":"135416603","term_text":"EP128533"}}EP128533 was inactive. Ribavirin, UDA and Ampligen™ decreased IL-6 expression. Strain v2163 provided a valuable model for anti-SARS research.
Context Exp S1: No visual cues
Creators: name: Ludvig, Elliot
name: Madan, Christopher
name: Spetch, Marcia
name: Mason, Alice
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: behavioral economics
subject: decisions from experience
subject: memory
subject: memory biases
subject: risky decision making

description: Data and Materials for Exp S1 in the paper supplement
title: Metal artifact reduction for total hip prosthesis in helical computed tomography: single energy metal artifact reduction versus forward projected model-based iterative reconstruction solution
Creators: name: Yasaka, Koichiro
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Prostheses
subject: Artifacts
subject: Physics
subject: Comparative studies
subject: CT
subject: Urinary Tract / Bladder
subject: Pelvis
subject: Lymph nodes

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Population aging is a global phenomenon. In step with the aging of the population, it is expected that the chance of utilization of the total hip arthroplasty (THA) would increase. Several diseases, such as infection and carcinoma, arise in the...
title: Method of contour analysis of neoplasms in X-ray mammograms
Creators: name: Romanycheva, Ekaterina
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Breast
subject: Mammography
subject: Diagnostic procedure
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Breast cancer tops the list of most common cancers among women worldwide. Therefore, early diagnosis of breast cancer remains one of the major challenges of contemporary oncology. Generally accepted standards for breast cancer disgnosis include...
Viewing Nature Scenes Helps Reduce the Pain of Social Ostracism
Creators: name: Yang, Ying
name: Wang, Lishen
name: Passmore, Holli-Anne
name: Zhang, Jing
name: Zhu, Lifang
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Other Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: ostracism, nature exposure, social pain, positive emotions, needs satisfaction

description: In a series of four studies (Ns = 245, 135, 155, 222), we explored the effects of viewing nature scenes on promoting recovery from ostracism. We first manipulated experiences of ostracism, then randomly assigned participants to view photos of either nature, urban scenes, or neutral objects. Across all four studies, participants who viewed nature photos reported significantly lower levels of state social pain, along with significantly higher levels of affect balance and self-esteem. Moreover, when asked to look back and recall how they felt at the time of being ostracized, participants who viewed nature photos reported significantly higher levels of retrospective satisfaction of basic emotional needs than did participants in control conditions. An internal meta-analysis revealed an effect size of d = 0.58. These studies are the first, to our knowledge, to provide experimental evidence of how exposure to nature can alleviate the pain of social ostracism.
Animal models and vaccines for SARS-CoV infection
Creators: name: Baric, Ralph
name: Jackson, Jadon P.
name: Lamirande, Elaine W.
name: Vogel, Leatrice
name: Paddock, Christopher D.
name: Roberts, Anjeanette
name: Zaki, Sherif R.
name: Subbarao, Kanta
name: Guarner, Jeannette
name: Sheahan, Timothy
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: We summarize findings of SARS-CoV infections in several animal models each of which support viral replication in lungs accompanied by histopathological changes and/or clinical signs of illness to varying degrees. New findings are reported on SARS-CoV replication and associated pathology in two additional strains (C57BL/6 and 129S6) of aged mice. We also provide new comparative data on viral replication and associated pathology following infection of golden Syrian hamsters with various SARS-CoV strains and report the levels of neutralizing antibody titers following these infections and the cross-protective efficacy of infection with these strains in protecting against heterologous challenge. Finally, we summarize findings of a variety of vaccine approaches and discuss the available in vitro and in vivo data addressing the potential for disease enhancement following re-infection in animals previously vaccinated against or infected with SARS-CoV.
What are the barriers affecting dietary intake in cardiac patients attending comprehensive cardiac rehabilitation programs? A Scoping Review Protocol (Registration)
Creators: name: Vanzella, Lais
name: Pakosh, Maureen
name: Deilami, Niloufar
name: Ajwani, Fatim
name: Rouse, Veronica
name: Oh, Paul
name: de Melo Ghisi, Gabriela
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Nutrition
subject: Life Sciences
subject: Food Science

description: This scoping review will be conducted to identify barriers to dietary intake reported in the literature by patients participating in a comprehensive cardiac rehabilitation program
title: Role of magnetic resonance imaging in diagnosis of fetal central nervous system congenital anomalies
Creators: name: Khalil, Alaa
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Congenital
subject: Technical aspects
subject: MR
subject: Neuroradiology brain
subject: Foetal imaging
subject: CNS

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The aim of this study is to assess the role of magnetic resonance imaging in evaluation of fetal central nervous system (CNS) congenital anomalies, involving the brain and spinal cord, which are suspected or inadequately assessed by...
Highly-Customizable 3D Printed Peristaltic Pump Kit
Creators: name: Ching, Terry
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Mechanical Engineering
subject: FOS: Mechanical engineering
subject: Engineering
subject: Biomedical Engineering and Bioengineering

description: This project contains (1) STL files to 3D print the pump kit component (2) Arduino code for the operation of the pump, and (3) Arduino code for flowrate calibration tool
title: Effect of the motion correction technique on image quality at 320-detector CT coronary angiography in patients with atrial fibrillation
Creators: name: Tatsugami, Fuminari
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Technology assessment
subject: CT-Angiography
subject: Cardiac
subject: Image verification
subject: Artifacts

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Coronary computed tomography angiography (CTA) is a robust noninvasive imaging modality that can yield an accurate diagnosis and exclude coronary artery disease (CAD) with a high degree of diagnostic accuracy. On 320-detector CT scanners it is...
Seaport Public Green: An Analysis of Use & Redesign
Creators: name: Seltzer, Lara
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: The quality of public open space in Boston’s Seaport District is not great, as evidenced by the oversaturation of empty, underutilized lawns and residents’ feelings that there is still a lack of public open space in the District, despite all the lawns. This Master’s Project asked how the quality of public open space could be improved in the District, and specifically focused on one lawn in particular that possesses great potential to be an active space and contribute to the District overall. I used interviews with practitioners, and conducted a site analysis of Seaport Public Green to understand the shortcomings of the existing design. Through this process, I found that Seaport Public Green is underutilized because of its lack of true connection to the Boston Harbor, its presentation as uninviting and as a foreground to the surrounding architecture, and its inability to provide a unique and exciting experience for users. My proposed redesign of Seaport Public Green addresses these shortcomings by enhancing the sightline of the Boston Harbor, adding stormwater management components to the park, taking measures, including leveling the lawn to meet the sidewalk at ground level, to connect the park to its surroundings, and by creating a marshy wet pond and kiosk that provides a unique experience to engage with nature and the history of the District.
title: Fast breast MRI and diffusion kurtosis in characterization of the breast lesions
Creators: name: Christou, Alexandra
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Breast
subject: MR-Diffusion/Perfusion
subject: Imaging sequences
subject: Diagnostic procedure
subject: Outcomes analysis
subject: Cancer
subject: Outcomes
subject: Image verification

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The aim of this study is to evaluate the accuracy of the combined fast magnetic resonance imaging (MRI) and diffusion kurtosis imaging (DKI) in the characterization and differentiation of the breast...
‘Where Reason Fails, There Faith Prevails’: The Evangelical Enlightenment of Isaac Watts
Creators: name: Johnson, Daniel
Publisher: name: University of Leicester
Year: 2024

description: Isaac Watts (1674-1748) was an Independent minster, hymnwriter, and logician. He was a prominent figure within moderate Dissent, a descendent of the Puritan tradition, and (in later life) an influential leader in the emerging evangelical movement. He was one of the most widely published writers in his lifetime and beyond, known and disseminated on both sides of the Atlantic. While aspects of his work and thought have received scholarly attention, his method and approach have been given little analysis. This thesis will situate Watts within the context of the early eighteenth century, examining the ways he synthesised his various influences into a consistent approach.Locating Watts at the intersection of three contested movements – Puritanism, the early Enlightenment, and early Evangelicalism – this thesis explores how Watts sought to transmit his Puritan inheritance by combining it with elements of Enlightenment thought in a manner that had significant implications for Evangelicalism. Chapter One considers the relationship between his hymnody and his logic. Chapter Two explores Watts’ relationship to Scripture. Chapter Three examines Watts’ controversial Christological formulations. Chapter Four looks at the relationship between Watts’ health and his doctrines of providence, the passions, and the will.By drawing upon a range of archival manuscripts, a more rounded picture of Watts emerges than has previously been presented. Watts modified and transmitted the legacy of the Puritan tradition while also appropriating what he perceived to be the best of the emerging new philosophies, shaping the evangelical movement through his published works and personal relationships. In conclusion, this thesis will demonstrate that Watts’ view of Scriptural authority guided his employment of reason, in order to rightly govern the passions, and so to produce a life of affectionate piety and devotion.
Telehealth Physical Therapy: Improving Physical Therapy Access and Improving North Carolinians' Health
Creators: name: Smith, Victoria
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: The state of North Carolina (NC) ranks in the lower third in health rankings. Contributing factors to NC’s public health concerns include chronic disease and injuries. The combination of the two are the leading causes of death for North Carolinians. In addition, NC has a high child poverty, diabetes, premature death and health disparities. Two significant NC public health problems include obesity and opioid abuse. Both conditions share some linkage to musculoskeletal problems such as pain and mobility difficulties. As such, incorporating the knowledge and skill sets of physical therapist should be utilized when addressing these conditions. Unfortunately, there are several challenges to health care access in NC. Seventy percent of NC’s counties are rural, there are notable health care providers shortages (i.e. physical therapist, physicians, etc.), and currently there is COVID-19 pandemic further limiting health care access. This paper will highlight telehealth physical therapy as an option for addressing the needs of obese population and those using or at risk for opioid abuse. This paper will also discuss how integrating telehealth physical therapy into clinical and community partnerships and integrated care models could successfully address some of North Carolina’s pressing public health and population health needs.
Keywords: obesity, opioids, physical therapy, telehealth, rural, access, public health
Data
Creators: name: Secker, Rosie
name: Braithwaite, Elizabeth
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Demographic factors
subject: Knife crime
subject: Post-traumatic stress disorder
subject: PTSD
subject: Secondary traumatic stress
subject: Secondary traumatic stress scale
subject: Social media

description: See https://osf.io/6n5a9/ for data used in the study.