cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Transculturalism in Chicano Literature, Visual Art, and Film
Creators: name: Mabry, Sarah
Publisher: name: Brandeis University
Year: 2018
Subjects: Transculturalism; Chicano Movement; Cultural Identity; Border Spaces; Helena Maria Viramontes; Chicano Park; Quetzalcoatl

description: This thesis will look at Chicano culture through selected works of literature, film, and visual art. All three cultural artifacts share a common geographic space in southern California and were inspired by and created during the Chicano Movement of the 1960s and 1970s and exhibit facets of Chicana/o cultural identity, forging a new condition to inspire future societal change. Historian Deborah Cohen explains that the prefix “trans-” preceding “nationalism” signifies three distinct understandings: “trans-” as going beyond, which denaturalizes the nation-state as the definitive form of human organization; “trans-” as relational, formed in the in-between spaces; and “trans-” as change, as in the subject position formed and in play between nations and through crossing borders. Deborah Cohen’s unpacking of transnationalism is useful when analyzing interlocking vignettes of each Chicano work of art, namely a novel Their Dogs Came with Them by Helena Maria Viramontes, a documentary film Chicano Park and a mural painting Quetzalcoatl, as each can be interpreted as one of three ways of experiencing a transcultural Chicano identity. We embark on a journey through film, literature, and art to illuminate the Chicana/o experience in the United States through a multi-artistic approach.
Lateral prefrontal model-based signatures are reduced in healthy individuals with high trait impulsivity
Creators: name: Deserno, L.
name: Wilbertz, T.
name: Reiter, A.
name: Horstmann, A.
name: Neumann, J.
name: Villringer, A.
name: Heinze, H.-J.
name: Schlagenhauf, F.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: High impulsivity is an important risk factor for addiction with evidence from endophenotype studies. In addiction, behavioral control is shifted toward the habitual end. Habitual control can be described by retrospective updating of reward expectations in ‘model-free’ temporal-difference algorithms. Goal- directed control relies on the prospective consideration of actions and their outcomes, which can be captured by forward-planning ‘model-based’ algorithms. So far, no studies have examined behavioral and neural signatures of model- free and model-based control in healthy high-impulsive individuals. Fifty healthy participants were drawn from the upper and lower ends of 452 individuals, completing the Barratt Impulsiveness Scale. All participants performed a sequential decision-making task during functional magnetic resonance imaging (fMRI) and underwent structural MRI. Behavioral and fMRI data were analyzed by means of computational algorithms reflecting model-free and model-based control. Both groups did not differ regarding the balance of model-free and model-based control, but high-impulsive individuals showed a subtle but significant accentuation of model-free control alone. Right lateral prefrontal model-based signatures were reduced in high-impulsive individuals. Effects of smoking, drinking, general cognition or gray matter density did not account for the findings. Irrespectively of impulsivity, gray matter density in the left dorsolateral prefrontal cortex was positively associated with model-based control. The present study supports the idea that high levels of impulsivity are accompanied by behavioral and neural signatures in favor of model-free behavioral control. Behavioral results in healthy high-impulsive individuals were qualitatively different to findings in patients with the same task. The predictive relevance of these results remains an important target for future longitudinal studies.
Development of a Genetics Education Tool for the Non-medical Staff of Perkins School for the Blind Secondary Program
Creators: name: Casner, Sarah
Publisher: name: Brandeis University
Year: 2010
Subjects: subject: Perkins School for the Blind
subject: Education tool
subject: Genetics
subject: FOS: Biological sciences

description: Hereditary disease is a leading cause of blindness in children in the United States and other developed countries, where environmental causes of blindness, such as vitamin deficiencies, are less prevalent. Many hereditary causes of blindness are syndromic, and children affected by these diseases have multiple impairments. It is therefore important that those who provide care to these children understand the etiology of their diagnoses. The purpose of our study was to assess interest in a genetics education tool for care providers of children with hereditary blindness, and to develop and pilot test such a tool based on the outcome of the assessment. We surveyed the non-medical staff of the Perkins School for the Blind Secondary Program regarding their interest in and understanding of many different genetic causes of blindness, and their preferences with respect to the format and content of an educational tool. We found that the survey respondents were most interested in learning about Bardet-Biedl syndrome, Batten disease, Leber congenital amaurosis, retinitis pigmentosa, retinoblastoma, and septo-optic dysplasia, all common among students who attend Perkins. The respondents indicated a preference for an in person seminar, rather than online video, book, or fact sheets. We conducted two educational seminars and attendees were asked to complete a survey evaluating the usefulness and effectiveness of the seminars. The respondents indicated that the information they learned was useful to them, and will be a positive influence on the care they provide to students they interact with. Our findings suggest that non-genetics care providers may benefit from educational seminars that focus on genetic aspects of the specific populations they serve. Individual relationships between genetics professionals and care providers in specialty settings such as Perkins may allow for more effective educational interventions than would the use of written materials or recorded media.
Design and realization of a Bragg grating prism on planar integrated optical waveguides for wideband photonic true time-delay beamforming
Creators: name: Blais, Sebastien
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Engineering, Electronics and Electrical.
subject: Physics, Optics.

description: This thesis presents a simulation and experimental study of a true time-delay (TTD) beamforming network using a Bragg grating prism on Ge-doped silica-on-silicon planar integrated optical waveguide for application in phased array antennas (PAA). The Bragg grating prism is designed and fabricated on planar optical waveguides and the true time-delay beamforming module is implemented using the fabricated waveguide Bragg grating prism and other photonic components. When dealing with a remotely controlled PAA, the dispersive properties of a standard single mode fiber must be taken under consideration. To this effect, a simulation study has been carried out and is detailed in this thesis. The Bragg grating prism used in the beamformer is composed of chirped gratings of different lengths but of same total chirp in order to produce a true time-delay progression. Two modulation techniques are considered, single sideband (SSB) and double sideband (DSB) modulation. SSB modulation is shown to be well suited for broadband operations with little impact on the orientation of the mainlobe resulting from chromatic dispersion. (Abstract shortened by UMI.)
Coping with Academic Examination Anxiety and Disordered Eating Symptoms
Creators: name: Liu, Xinyu
Publisher: name: Brandeis University
Year: 2023
Subjects: Academic Anxiety
Coping styles
Disordered Eating Symptoms
Moderation

description: Academic anxiety is proven to be linked with disordered eating symptoms. Coping styles moderate the relationship between anxiety and disordered eating symptoms. This study aimed to determine if academic anxiety is positively linked with disordered eating symptoms both at the beginning of the semester and the end of the semester. Further, we hypothesized different coping styles moderate this relationship the same way they moderate the relationship between social anxiety and disordered eating symptoms. We hypothesized that higher academic anxiety is associated with higher disordered eating symptoms, and coping styles moderate this relationship.Methods: A series of self-report questionnaires were answered by undergraduate Brandeis students at the beginning of the semester and the end of the semester, which asked about disordered eating symptoms, general anxiety, academic anxiety, and coping styles. Then the models were fitted in R with an SEM model.
description: Results: Controlling for general anxiety, academic anxiety cannot predict disordered eating symptoms. Only those higher in avoidance-oriented coping have a reduced association between academic anxiety and disordered eating symptoms.
description: Discussion: The results were limited by the small sample size and measurement for academic anxiety can be improved.
Edición modernizada y anotada de la comedia No hay burlas con las mujeres, o, Casarse y vengarse, del doctor Antonio Mira de Amescua.
Creators: name: Sanchez Tallon, Carmen.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1993
Subjects: subject: Literature, Romance.

description: The purpose of this M.A. thesis is to present a modernized and annotated edition of a Spanish Golden Age play, No hay burlas con las mujeres o casarse y vengarse by the Spanish poet and playwright Antonio Mira de Amescua, applying the methodology of textual criticism. This edition is based on the princeps printed text, published in the Quinta parte de comedias escogidas de los mejores ingenios de Espana. Madrid. Pablo de Val 1653. Biblioteca Nacional de Madrid (R-22658). The thesis begins with an Introduction which is divided into two sections. The first section gives a brief account of Mira de Amescua's life and works. The second section of the Introduction is itself divided into four different parts which provides information about the text of the play, its structure and versification, staging, and the editorial criteria used. The main body of the thesis consists of the text of the play itself whose spelling and punctuation have been modernized, according to the standard practice. The critical apparatus consists of two sets of notes: philological notes, which explain archaic vocabulary, historical and mythological allusions and other references in the text; and textual notes, which record spelling and versification mistakes, and other textual matters.
Identity and politics: Second generation ethnic women in Canada.
Creators: name: Rajiva, Mythili.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Canadian Studies.

description: This thesis is interested in how intersections of gender, race, and class inform the social and self constructions of identity in the lives of second generation ethnic Canadian women. It is based on the assumption that the social incompatibility of ethnicity and Canadian identity impacts on their political behaviour, and their sense of themselves as Canadian citizens. The thesis is composed of a theoretical discussion of the relevant literature, and the empirical results of fifteen interviews with the subjects in question. It attempts to demonstrate that the specificity of the subjects' identities is not being acknowledged by mainstream discourses on ethnicity, citizenship, and feminism, which are either gender blind, or define all ethnic women as immigrant women. While recognizing the importance of research on immigrant women, I would argue that such a label is not all encompassing, and in fact, casts the debate in a particular fashion: by suggesting that the immigrant experience is the central focus in the intersection of race and ethnicity, it obscures the significance underlying the consistent linking of ethnicity with immigration. In my discussion of the shortcomings inherent in such approaches, I conclude that there is a need for better understanding of the multiplicity of ethnic women's experiences, through the development of broader and more inclusive theoretical frameworks that seek to understand and theorize these complexities, rather than essentializing them.
The Role of PAR-bZIP Transcription Factors in Audiogenic Seizures
Creators: name: Cepeda, Isabel
Publisher: name: Brandeis University
Year: 2021
Subjects: Spontaneous Death
Audiogenic Seizures
Seizures
Homeostatic Plasticity
Death or Mortality
Epilepsy

description: Homeostatic plasticity is a set of mechanisms that keep neuronal activity within a functional range. Various mechanisms of homeostatic plasticity are under transcriptional control. Past studies from the Nelson Lab have shown that out of three transcription factors (TFs) of the PAR-bZIP transcription factor family (HLF, TEF, and DBP), HLF and TEF restrain network activity in response to environmental stimuli. Here, we explore the role of these transcription factors in seizure propensity in vivo. We found that HLF, TEF, and DBP may function to reduce the frequency of spontaneous death (SD) due to seizure. We then tested whether rearing TKOs in an enhanced auditory environment would reduce spontaneous death propensity, however we observed no change in survival. Finally, we developed a video analysis script to detect seizures as a more sensitive measure than SD. Overall, these findings contribute to our understanding of the pathophysiology behind seizures in mice lacking HLF, TEF, and DBP.
title: ÐÐ¾Ð²ÑÑÐµÐ½Ð¸Ðµ ÐºÐ°ÑÐµÑÑÐ²Ð° Ð²ÐµÑÐ¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¸ Ð´Ð¸ÐºÑÐ¾ÑÐ° Ð² ÑÐµÐ»ÐµÑÐ¾Ð½Ð½Ð¾Ð¼ ÐºÐ°Ð½Ð°Ð»Ðµ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Improving the quality of speaker verification on the telephone channel
Creators: name: ÐÐ½Ð¸ÐºÐ¸Ð½, ÐÐ»ÐµÐºÑÐ°Ð½Ð´Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: Ð¼Ð°ÑÐ¸Ð½Ð½Ð¾Ðµ Ð¾Ð±ÑÑÐµÐ½Ð¸Ðµ
Ð²ÐµÑÐ¸ÑÐ¸ÐºÐ°ÑÐ¸Ñ Ð´Ð¸ÐºÂ­ÑÐ¾ÑÐ°
Ð¿ÑÐµÐ´Ð²Ð°ÑÐ¸ÑÐµÐ»ÑÐ½Ð¾Ðµ Ð¾Ð±ÑÑÐµÐ½Ð¸Ðµ
machine learning
speaker verification
pre-training

description: Ð¦ÐµÐ»ÑÑ Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ ÑÐ²Ð»ÑÐµÑÑÑ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð¼Ð°ÑÐ¸Ð½Ð½Ð¾Ð³Ð¾ Ð¾Ð±ÑÑÐµÐ½Ð¸Ñ Ð´Ð»Ñ Ð·Ð°Ð´Ð°ÑÐ¸ Ð²ÐµÑÐ¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¸ Ð´Ð¸ÐºÑÐ¾ÑÐ°, ÐºÐ¾ÑÐ¾ÑÐ°Ñ Ð¿Ð¾Ð·Ð²Ð¾Ð»Ð¸Ñ Ð¿ÑÐ¸Ð¼ÐµÐ½ÑÑÑ Ð¼Ð¾Ð´ÐµÐ»Ñ Ð² ÑÐµÐ»ÐµÑÐ¾Ð½Ð½Ð¾Ð¼ ÐºÐ°Ð½Ð°Ð»Ðµ, Ð¿ÑÐ¸ ÑÑÐ¾Ð¼ ÑÑÐµÐ±ÑÐµÑÑÑ ÑÐ¾ÑÑÐ°Ð½Ð¸ÑÑ ÐºÐ°ÑÐµÑÑÐ²Ð¾ Ð½Ð° Ð¼Ð¸ÐºÑÐ¾ÑÐ¾Ð½Ð½ÑÑ Ð´Ð°Ð½Ð½ÑÑ Ð±Ð»Ð¸Ð·ÐºÐ¾Ðµ Ðº ÑÑÐ¾Ð²Ð½Ñ ÑÐ¾Ð²ÑÐµÐ¼ÐµÐ½Ð½ÑÑ ÑÐ¸ÑÑÐµÐ¼ Ð²ÐµÑÐ¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¸ Ð´Ð¸ÐºÑÐ¾ÑÐ°. Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð±ÑÐ»Ð¾ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¾ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÐ¾Ð²ÑÐµÐ¼ÐµÐ½Ð½ÑÑ ÑÐ¸ÑÑÐµÐ¼, Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ñ Ð¸Ñ ÑÐ¸Ð»ÑÐ½ÑÐµ Ð¸ ÑÐ»Ð°Ð±ÑÐµ ÑÑÐ¾ÑÐ¾Ð½Ñ. ÐÐ¾ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐ°Ð¼ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð±ÑÐ»Ð° Ð²ÑÐ±ÑÐ°Ð½Ð° Ð°ÑÑÐ¸ÑÐµÐºÑÑÑÐ° ÑÐµÑÐ¸ wav2vec, ÑÐ°ÐºÐ¶Ðµ Ð±ÑÐ»Ð° Ð¿ÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ð° Ð¼Ð¾Ð´Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ñ ÑÑÐ½ÐºÑÐ¸Ð¸ Ð¾ÑÐ¸Ð±ÐºÐ¸. ÐÐ¾Ð»ÑÑÐµÐ½Ð½Ð°Ñ Ð¼Ð¾Ð´ÐµÐ»Ñ ÑÑÐ°Ð²Ð½Ð¸Ð²Ð°ÐµÑÑÑ Ñ Ð¼Ð¾Ð´ÐµÐ»ÑÑ wav2vec base, ÐºÐ¾ÑÐ¾ÑÑÑ Ð¾Ð¿ÑÐ±Ð»Ð¸ÐºÐ¾Ð²Ð°Ð»Ð¸ Ð°Ð²ÑÐ¾ÑÑ Ð°ÑÑÐ¸ÑÐµÐºÑÑÑÑ. ÐÑÐµÐ´Ð»Ð°Ð³Ð°ÐµÐ¼Ð°Ñ Ð¼Ð¾Ð´ÐµÐ»Ñ Ð¾Ð±ÑÐ¾Ð´Ð¸Ñ Ð² Ð»ÑÑÑÐµÐ¼ ÑÐ»ÑÑÐ°Ðµ Ð¿ÑÐ¸Ð¼ÐµÑÐ½Ð¾ Ð½Ð° 5\% EER Ð¼Ð¾Ð´ÐµÐ»Ñ wav2vec base Ð½Ð° ÑÐµÐ»ÐµÑÐ¾Ð½Ð½Ð¾Ð¼ ÐºÐ°Ð½Ð°Ð»Ðµ, Ð¿ÑÐ¸ ÑÑÐ¾Ð¼ Ð¿Ð¾ÑÐµÑÐ¸ Ð½Ð° Ð¼Ð¸ÐºÑÐ¾ÑÐ¾Ð½Ð½Ð¾Ð¼ ÐºÐ°Ð½Ð°Ð»Ðµ ÑÐ¾ÑÑÐ°Ð²Ð»ÑÑÑ Ð½Ðµ Ð±Ð¾Ð»ÐµÐµ 0.5\% EER.
description: The goal of this work is to develop a machine learning model for the speaker verification task, which allows the model to be used in a telephone channel, while maintaining the quality of microphone data close to the level of modern speaker verification systems. In this work, a study of modern systems was carried out, their strengths and weaknesses were presented. Based on the results of the study, the wav2vec network architecture was chosen, and a modification of the error function was also proposed. The resulting model is compared with the wav2vec base model, which was published by the authors of the architecture. The proposed model at best outperforms the wav2vec base model on the telephone channel by about 5\% EER, while the losses on the microphone channel are no more than 0.5\% EER.
Investigating positive-valance operant learning in Drosophila melanogaster with a novel apparatus
Creators: name: Liu, Jeffrey
Publisher: name: Brandeis University
Year: 2020
Subjects: operant learning
Drosophila melanogaster

description: Associative learning underlies much of animal behavior, explaining why dogs salivate upon smelling food or why we check our phones even without notification. Operant learning is a subset of associative learning and pairs behaviors with reinforcing stimuli. Additionally, it has significance in treatment of chronic pain, anxiety, and OCD. Drosophila melanogaster serve as an excellent model organism for studying the cellular basis behind behaviors and diseases, sharing many of the same diseases-causing genes with humans. While there has been extensive study in learning in Drosophila, little work has been done using pure operant paradigms. We developed a novel, high-throughput, positive-valance paradigm for operant conditioning, training flies to develop a turning bias towards sugar. Using this apparatus, we found a link between flies sleeping early in training and a significant change in learning. Using yoked-controls and sleep induction, we determined that the sleep-learning link is not causal in either direction, but early sleep is necessary for learning. We also screened flies homozygous for one of two isotypes of the foraging gene, rover (for[R]) and sitter (for[s]), as well as a known learning-deficient mutant, dunce (dnc[1]). We found that dnc[1] flies cannot learn this task, suggesting positive-valance operant learning is mediated through a cAMP-dependent pathway. Furthermore, while sitter flies cannot learn this task, rovers do, but show a revealed preference against sugar, implicating the foraging gene in operant learning. Ultimately, we have shown that this novel paradigm is capable of operantly training flies and shed insight onto possible mechanistic pathways.
title: Mobile Electronic Medical Records Promote Workflow
title: Physicians’ Perspective From a Survey
titleType: Subtitle
Creators: name: Duhm, Julian
name: Fleischmann, Robert
name: Schmidt, Sein
name: Hupperts, Hagen
name: Brandt, Stephan A.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: tablet PC
subject: electronic health record
subject: usability
subject: health services
subject: inpatient care
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background: As a result of demographic changes, physicians are required to deliver needed services with limited resources. Research suggests that tablet PCs with access to patient data may streamline clinical workflow. A recent study found tablets with mobile electronic medical records (EMRs) can facilitate data retrieval and produce time savings across the clinical routine within hospital settings. However, the reasons for these time savings, including details on how tablets were being used, remain unclear. The same applies to physicians’ perceptions of this tool within an inpatient setting. Objective: This study examined physicians’ perception of tablets with EMRs in an inpatient setting. The rationale was to identify both subjective and objective factors that impacted the successful implementation and use of tablets running an EMR. Methods: We developed a 57-item survey questionnaire designed to examine users’ perception of and attitude toward tablets, which was administered to 14 participating physicians following 7 weeks of tablet use. Five participants volunteered to participate in a second study that investigated physicians’ patterns of tablet use within the EMR environment by digitally tracking and storing usage behavior. Statistical analyses of questionnaire results included mean values with their bootstrapped 95% confidence intervals and multivariate analysis of variance to identify predictors of tablet use. Results: Physicians reported high degrees of satisfaction with the tablets. There was a general consensus among physicians that tablet use streamlined clinical workflow through optimized data retrieval (rated 0.69, 0.23-1.15 points better than control) and improved communication with patients and other physicians (rated 0.85, 0.54-1.15 and 0.77, 0.38-1.15 points better than control, respectively). Age (F3,11=3.54, P=.04), occupational group (F1,11=7.17, P=.04), and attitude toward novel technologies (F1,11=10.54, P=.02) predicted physicians’ satisfaction with the devices and their motivation regarding their further use. Tracking data yielded that only a few of the available functions were used frequently. Conclusions: Although tablet PCs were consistently perceived as beneficial, several factors contributed to the fact that their full potential was not fully exploited. Training in functionality and providing a reliable infrastructure might foster successful tablet implementation.
Saving Jews: The History of Jewish-Christian Relations in Scotland, 1880-1948
Creators: name: Imber, Elizabeth E.
Publisher: name: Brandeis University
Year: 2010
Subjects: antisemitism
Jewish-Christian Relations
Scottish Jewish history
philo-Semitism
Christian Zionism
missions
Scottish history
Edinburgh
British Jewry
Salis Daiches
Glasgow
Jewish History
Scotland

description: This thesis examines the history of Jewish-Christian relations in Scotland from 1880-1948. It explores the changing role of the Jew in the Scottish religious consciousness by analyzing the concept of “saving Jews.” From the advent of Scottish missions to the Jews in 1839 until the early 1900s, “saving Jews” meant saving Jewish souls through conversion to Christianity. However, by the 1930s, “saving Jews” came to mean preserving Jewish life by supporting the establishment of a Jewish homeland in Palestine and by urging the British government to intervene in Nazi Germany. By the founding of the State of Israel in 1948, the Scottish evangelistic impulse had essentially been abandoned, and the Jewish and Christian communities in Scotland had developed a strong, sincere friendship. Yet, this shift was hardly a manifestation of Scottish Christian secularization. Rather, Scottish Christians viewed their ties to the Jewish community, their commitment to Zionism, and their efforts to fight antisemitism and Nazism as fundamental expressions of their Christian faith. Drawing on a large collection of primary sources including church records, Scottish and Jewish newspapers, interviews, autobiographies, and other archival documents, this thesis offers an alternative interpretation of the popular notion that secularization is always a benefit to the Jewish community.
A diagnostic tool for the identification of noise in Augmentative and Alternative Communication: A case study about adults with Complex Communication Needs
Creators: name: Britton, Shaun
Publisher: name: Swinburne
Year: 2024

description: Approximately 1.5% of individuals in western countries have Complex Communication Needs, meaning that they lack the spoken word skills needed for their daily communication. Therapeutic methods, called Augmentative and Alternative Communication, exist to help these people, but the use of such techniques is typically problematic.
The identification of where communication breakdowns occur is one of the major challenges within this unique environment. Having a tool that allows users to identify these breakdowns could provide a means to address this issue. This thesis presents literature and empirical research that investigates these challenges, and a prototype tool intended to identify communication breakdowns.
title: Design Innovation Networks: Critical factors that can contribute to successful collaborative development of innovative products
Creators: name: Bussracumpakorn, Chokeanand
Publisher: name: Goldsmiths, University of London
Year: 2006

description: My study starts from the assumption that, in the post-industrial economy, organisations are surrounded by increasing complexities in their external environment. The dynamic and unpredictable conditions of external environments cause internal instabilities which force organisations to find a survival strategy. Many studies suggest that the development of innovative products is an important strategy in this economy. However, it is a very high risk activity. To develop innovative products, many organisations, in particular small and medium-sized businesses, experience two main problems: (i) high, fixed costs and uncertainties during the product development process and (ii) the limitations of their in-house resources and knowledge. Based on the tensions between the dynamic changes and unpredictability of external economic and market conditions, and the problems and limitations of product development within organisations, my study suggests that organisation networks are helpful for the development of innovative products. My study comprises two stages. First, it investigates both theoretical and empirical studies related to the concept of networks in different areas: philosophy, biology, system theory and socioeconomics. Based on the analysis of these studies, it suggests that collaborative networks of multidisciplinary organisations are helpful in the development of innovative products in the post­industrial economy. Secondly, my study focuses on the examination of key factors, the effects of each factor, and the level of mutuality of these factors within successful collaborative networks. Four successful collaborative networks created for the development of innovative products within the UK during 1997- 2003 are qualitatively examined. The main research focus concerns the structural relations between the collaborative organisations, particularly the interactions between the main points of contact. The research findings suggest sixteen key factors, and nine out of them emerge to be dominant: (1) mutual trust, (2) equal valuing of working role, (3) clear agreement of the collaborative benefits, ( 4) an effective communication protocol, (5) flexible collaborative product development, (6) open information sharing, (7) mutual understanding between the parties, (8) commitment at all levels, and (9) innovation culture of each organisation.
title: ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¿Ð¾ ÑÐµÐ¾ÑÐ¸Ð¸ Ð¿ÑÐ¸Ð¾ÑÐ¸ÑÐµÑÐ½ÑÑ ÑÐ¸ÑÑÐµÐ¼ Ð¾Ð±ÑÐ»ÑÐ¶Ð¸Ð²Ð°Ð½Ð¸Ñ Ñ Ð²ÐµÑÐ¾ÑÑÐ½Ð¾ÑÑÐ½ÑÐ¼ Ð²ÑÑÐ°Ð»ÐºÐ¸Ð²Ð°ÑÑÐ¸Ð¼ Ð¼ÐµÑ Ð°Ð½Ð¸Ð·Ð¼Ð¾Ð¼
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Research on the theory of priority service systems with probabilistic push mechanism
Creators: name: ÐÐ°ÐºÑÐµÐµÐ², ÐÐ¸ÑÐ°Ð»Ð¸Ð¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: ÑÐµÐ¾ÑÐ¸Ñ Ð¼Ð°ÑÑÐ¾Ð²Ð¾Ð³Ð¾ Ð¾Ð±ÑÐ»ÑÐ¶Ð¸Ð²Ð°Ð½Ð¸Ñ
Ð°Ð±ÑÐ¾Ð»ÑÑÐ½ÑÐ¹ Ð¿ÑÐ¸Ð¾ÑÐ¸ÑÐµÑ
Ð²ÐµÑÐ¾ÑÑÐ½Ð¾ÑÑÐ½ÑÐ¹ Ð²ÑÑÐ°Ð»ÐºÐ¸Ð²Ð°ÑÑÐ¸Ð¹ Ð¼ÐµÑ Ð°Ð½Ð¸Ð·Ð¼
Ð¿ÑÐ¾ÑÐ¸Ð»Ð°ÐºÑÐ¸ÐºÐ° ÐºÐ°Ð½Ð°Ð»Ð° Ð¾Ð±ÑÐ»ÑÐ¶Ð¸Ð²Ð°Ð½Ð¸Ñ
queueing theory
absolute priority
probabilistic push mechanism
vacation

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description: The work systematically studies a new class of two-stream single-channel priority QS with a preemptive priority, randomized push-out mechanism and vacations. In addition to the classical types of vacation (single and multiple vacations), randomized vacations is also being studied. The main attention is paid to the analysis of the probabilities of losses, as well as the likelihood of vacation. The work is a continuation and development of the authorâs bachelorâs work. The method of generating functions is used in the modification proposed by A. S. Ilyashenko.
Causal Evidence for the Role of Specific GABAergic Interneuron Types in Entorhinal Recruitment of Dentate Granule Cells
Creators: name: Lee, Cheng-Ta
name: Kao, Min-Hua
name: Hou, Wen-Hsien
name: Wei, Yu-Ting
name: Chen, Chin-Lin
name: Lien, Cheng-Chang
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: Cellular
subject: neuroscience
subject: Neural circuits
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: The dentate gyrus (DG) is the primary gate of the hippocampus and controls information flow from the cortex to the hippocampus proper. To maintain normal function, granule cells (GCs), the principal neurons in the DG, receive fine- tuned inhibition from local-circuit GABAergic inhibitory interneurons (INs). Abnormalities of GABAergic circuits in the DG are associated with several brain disorders, including epilepsy, autism, schizophrenia, and Alzheimer disease. Therefore, understanding the network mechanisms of inhibitory control of GCs is of functional and pathophysiological importance. GABAergic inhibitory INs are heterogeneous, but it is unclear how individual subtypes contribute to GC activity. Using cell-type-specific optogenetic perturbation, we investigated whether and how two major IN populations defined by parvalbumin (PV) and somatostatin (SST) expression, regulate GC input transformations. We showed that PV-expressing (PV+) INs, and not SST- expressing (SST+) INs, primarily suppress GC responses to single cortical stimulation. In addition, these two IN classes differentially regulate GC responses to θ and γ frequency inputs from the cortex. Notably, PV+ INs specifically control the onset of the spike series, whereas SST+ INs preferentially regulate the later spikes in the series. Together, PV+ and SST+ GABAergic INs engage differentially in GC input-output transformations in response to various activity patterns.
The Inhibition of Bacterial IMPDHs by Mutagenesis and Kinetic Studies
Creators: name: WANG, XINGYOU
Publisher: name: Brandeis University
Year: 2022
Subjects: enzyme kinetic
IMPDH
Antibiotics
Inhibitors

description: Inosine 5’-monophosphate dehydrogenase (IMPDH) catalyzes the oxidation of IMP to XMP, which is the rate-limiting step of de novo guanine nucleotide biosynthesis. The differences between mammalian IMPDHs and bacterial IMPDHs make this enzyme a promising antibiotic drug target. Selective inhibitors for bacterial IMPDHs have been developed that bind to the NAD+ site. Some inhibitors display varied potency even though the NAD+ site is highly conserved in IMPDHs from some important pathogens. Here, we hypothesized that protein dynamics, in particular the conformational movements of the active site flap, play an important role in inhibitor binding. In Chapter 2, we used IMPDH from Bacillus anthracis as a model system and introduced various point mutations in the active site flap. The most significant inhibitor-specific potency changes were observed when mutating Leu413 to Ala. Detailed kinetics studies on the wild-type enzyme and the L413A mutant involved both pre-steady-state kinetics and steady-state initial rate experiments. The results show that all inhibitors bind at least as strongly to the covalent intermediate E-XMP* as they do to the non-covalent complex E•IMP. Interactions with Leu413 determine the affinities to both complexes, for some, but not all, inhibitors. I conclude that the conformational dynamics of the flap needs to be considered in the rational design of IMPDH inhibitors.
description: Tuberculosis (TB) is a worldwide disease caused by bacteria called Mycobacterium tuberculosis (Mtb). The emergence of multidrug- and extensively-drug resistant TB calls for new drugs for TB treatment. While previously developed selective inhibitors for bacterial IMPDHs with different scaffolds were potent to MtbIMPDH, most of them display poor anti-tubercular activity. MtbIMPDH inhibitors with new scaffolds need to be developed. In Chapter 3, we performed screening against MtbIMPDH on compounds selected by an initial virtual HTS and identified three hits with novel scaffold. Further optimization is needed.
description: IMPDH controls the guanine nucleotide pool in cell. The inhibition of IMPDH causes the inhibition of cell growth. A hca pathway converting coumarate to protocatechuic acid (PCA) originates from Acinetobacter baylyi ADP1. When this pathway was transferred to E. coli, the resulting strain E. coli/hca cannot grow in the presence of coumarate. In Chapter 4, we performed in vitro studies on EcIMPDH and AbIMPDH. The results suggest that 4-Hydroxybenzaldehyde, the intermediateof hca pathway, inhibits EcIMPDH but not AbIMPDH. These results further emphasize the importance of IMPDH in cell growth.
Relationship between N-Terminal Pro-Brain Natriuretic Peptide, Obesity and the Risk of Heart Failure in Middle-Aged German Adults
Creators: name: Wirth, Janine
name: Buijsse, Brian
name: Giuseppe, Romina Di
name: Fritsche, Andreas
name: Hense, Hans W.
name: Westphal, Sabine
name: Isermann, Berend
name: Boeing, Heiner
name: Weikert, Cornelia
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Both high concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP) and obesity are related to higher heart failure risk. However, inverse relationships between NT-proBNP and obesity have been reported. Therefore, it was investigated whether the association between NT- proBNP and the risk of heart failure differed according to obesity status. Methods A case-cohort study was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam, comprising a random sub-cohort (non-cases = 1,150, cases = 13, mean age: 50.5±9.0 years) and heart failure cases outside the sub-cohort (n = 197). Weighted Cox proportional hazards regression was used to examine the association between NT-proBNP and heart failure risk during a mean follow-up time of 8 years. Stratified analyses were performed according to obesity status as defined by body mass index (<30 kg/m2 versus ≥30 kg/m2). Results Overall, NT-proBNP was associated with higher risk of heart failure after multivariable adjustment (hazard ratio (HR) and 95% confidence interval (CI): 2.56 (1.49–4.41) for the top versus bottom tertile of NT-proBNP, ptrend:<0.01). In stratified analyses, the shape of association was linear in non-obese and U-shaped in obese participants: HRs (95%CI) from the first to the third tertile of NT-proBNP for non-obese: reference, 1.72 (0.85–3.49), 2.72 (1.42–5.22), and for obese: 3.29 (1.04–10.40), reference, 3.74 (1.52–9.21). Conclusions Although high circulating concentrations of NT-proBNP were positively associated with incident heart failure in the entire sample, the association differed according to obesity status. In obese, an increased risk of heart failure was also observed in those with low NT-proBNP concentrations. If confirmed, this observation warrants further investigation to understand underlying pathophysiological mechanisms.
Enhancing galaxy kinematic modelling using novel hardware and software techniques and technologies
Creators: name: Bekiaris, Georgios
Publisher: name: Swinburne
Year: 2024

description: This thesis investigates how modern computer hardware and software technologies can be used to enhance the study of the internal motions of galaxies, in the era of large-scale surveys. In order to cope with the unprecedented amount of data produced by the new- and next-generation telescopes and instruments we suggest the use of massively parallel architectures and Web-based remote processing services. By using these techniques and technologies we are now able to analyse vast amounts of kinematic information, and expand our knowledge about the structure, formation, and evolution of galaxies.
Physiological role of bombesin-like peptides in the regulation of food intake: Ontogenic profile and mechanisms of action.
Creators: name: Plamondon, Hélène.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Biology, Neuroscience.

description: This research aimed to characterize the physiological role of bombesin-like peptides (BN-LP) in the control of ingestion. The first experiment assessed the developmental profile of BN response in rats, and demonstrated that BN effectively suppressed feeding from postnatal day (PD) 1 through PD 15. Pretreatment with BN receptor antagonist blocked this suppression, suggesting that BN receptors are functional and may participate in feeding regulation from the first hours following birth. We then examined whether endogenous levels of BN-LP in the brain changed in a meal-dependent manner. Of the 15 distinct nuclei examined, meal-related alterations in BN-LP were observed at the hypothalamic paraventricular (PVN), arcuate and dorsomedial nuclei and at the nucleus accumbens. These alterations appeared site and peptide specific since changes in CRF levels were restricted to the hypothalamic lateral and ventromedial nuclei and the central nucleus of the amygdala. To determine what these changes meant in terms of peptide utilization, we then monitored the in vivo release of BN-LP as compared to the preprandial and/or postprandial conditions, where the interstitial levels of BN-LP were relatively high. The next study examined whether sustained central exposure to a BN agonist affected spontaneous feeding, ingestive response to acute BN, or the density of BN receptors within the CNS. Feeding was suppressed over the initial 48 h of BN infusion, however, tolerance to this effect was apparent by 72 h and was associated with receptor down-regulation at the PVN and dentate gyrus. Acute BN administration suppressed feeding in both the chronic BN exposed and control groups indicating lack of tolerance to the acute fluctuations of BN. These findings imply the existence of different neural mechanism(s) mediating the acute versus long-term effects of BN. Finally, the potential interactions of BN with other satiety peptides were investigated. These studies revealed that BN partly mediates its satiety effects through interactions with CRF. The specificity of this interaction was supported by the lack of interaction between BN and/or CRF with oxytocin. This series of experiments provide novel data supporting the view that BN-LP play an important role in the regulation of food intake, and provide some new insights into their possible mechanism(s) of action.
"We are all sprung from under Gogol’s cloak": Ambivalence, Rumination, Disintegration in Dmitri Shostakovich's String Quartets
Creators: name: Heck, Matthew Paul
Publisher: name: Brandeis University
Year: 2021
Subjects: Dmitri Shostakovich
Petersburg text
Russian Language or Literature

description: This dissertation explores the parallels between the musical language of Dmitri Shostakovich’s quartets and a literary canon known as the “Petersburg text” that features works by Nikolai Gogol, Fyodor Dostoevsky, Andrei Bely, and Alexander Blok. Combining insights from Russian (Dolzhansky, Mazel, Kholopov) and anglophone (Brown, Segall) theorists, I present an analytical framework that explores and interprets his harmonic-contrapuntal idiom in connection with a ubiquitous literary-cultural context. Joining an established tradition of musicologists with similar goals (Kuhn, Reichardt, Sheinberg), I examine the realm of harmony and melody and establish simple mimetic harmonic and melodic structures—in the manner of “topics” (Ratner) when they govern small structures, “expressive genres” (Hatten) when they infuse whole works, and “narrative archetypes” (Almén) when they change from one thing to another—that reflect omnipresent themes, or “mythologemes,” of the Petersburg text, a constellation of linguistic, thematic, aesthetic, and historical themes and meta-themes most extensively theorized by the philologist Vladimir Toporov. Two previously established (Hakobian) themes in Shostakovich’s music connect book to score. On the one hand there is ambivalence, ambiguity, multivalence, paradox, profundity, and obscurity—rendered in texts with images of mist, fog, phantoms, doubles, dreams, illusions, and lamps. On the other hand, there is disintegration, decline, and decay—engaging with time, mortality, apocalyptic visions, illness, suicide, death, and always water: rivers, canals, storms, and floods. Chapter 1 situates the analytical framework within historical and contemporary Russian and anglophone theoretical and musicological perspectives. Chapter 2 addresses ambivalence and positions the approach within Russian and anglophone theoretical traditions. Chapter 3 explores a smaller sub-theme particularly present in Dostoevsky’s work—fixity, inertia, rumination and idée fixe. Chapter 4 explores the other major aesthetic pillar—disintegration and decline—incorporating a brief discussion of Bely’s Petersburg, and setting up an analysis of the composer’s Seventh String Quartet exemplary of the approach in Chapter 5.
Catalytic Conversion of Ethanol over Promoted Mixed Oxides
Creators: name: Guo, Mond F.
Publisher: name: Washington State University
Year: 2019
Subjects: Ethanol

description: Developing renewable pathways to replace petroleum-derived chemicals and products has become increasingly urgent. With a diminishing role as a fuel additive, ethanol has instead greater value as a versatile platform chemical that can be derived from a wide range of carbon sources. One of the most promising ethanol transformations is the Guerbet reaction, a multi-step reaction that allows facile C-C coupling of shorter chain alcohols into longer chain alcohols such as 1-butanol and 2-ethylhexanol, which sees numerous usages as chemicals and fuels. Recent work has seen development of numerous multi-functional catalytic approaches, but the tendency toward side reactions and cross condensation of intermediate products means that achieving both high selectivity and conversion remains challenging and prevents commercial application of this process. In this dissertation, we present our development of an economically viable catalytic system based on copper promoted mixed oxide catalysts capable of transforming ethanol to higher alcohols in high yield.We report here a highly selective approach to producing 1-butanol and higher alcohols over low copper doped MgAl hydrotalcite catalyst. In-operando characterization demonstrates that at these low concentrations, copper remains atomically disperse and is stabilized as Cu+1 sites, in contrast to higher copper formulations that resulted in in-situ reduction to metallic Cu0 clusters. This change in copper speciation and dispersion corresponded to a stark change in the reaction data as well, where copper clustering was correlated to unselective formation of esters and ketones side products. This work demonstrated for the first time Guerbet condensation to higher alcohols with a selectivity over 80% at high conversions (>65%). Optimization of reaction conditions under high H2 partial pressures mitigated the primary deactivation mechanism, leading to extended catalyst lifetimes. Further improvements to catalytic performance were achieved by improving stability of the disperse copper sites through physical and chemical modifications of the support. Finally, the industrial viability of this catalytic system was demonstrated through a technoeconomic evaluation of an ethanol to 1-butanol process, with a minimum estimated butanol selling price that is cost competitive with the current 1-butanol market.
Requirements for the binding of glucocorticoid receptor to octamer transcription factor-1, in vitro.
Creators: name: Préfontaine, Gratien G.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Biology, Molecular.

description: Nuclear receptors and POU transcription factors have been shown to regulate gene transcription through complex cis-acting elements located in upstream promoter regions of target genes. Regulation has been shown to occur through both synergistic and inhibitory mechanisms. Specifically, glucocorticoid dependent transcriptional synergism has been observed within complex regulatory elements on the mouse mammary tumor virus Long Terminal Repeat (MMTV LTR) that contain binding sites for both the glucocorticoid hormone nuclear receptor (GR) and the ubiquitous POU factor, octamer transcription factor-1 (Oct-1). By contrast, on promoters like that of the histone H2B gene that contains regulatory elements only for Oct-1, glucocorticoids actually appear to inhibit the activation of gene transcription by Oct-1. Previous experimental observations were suggestive of a direct physical interaction between the DNA binding domain of GR and the POU DNA binding domain of Oct-1. In this work I have examined the requirements for the binding of in vitro translated, radiolabeled GR to the POU domain of Oct-1 expressed as a glutathione-S-transferase (GST) fusion protein and immobilized on glutathione sepharose. (Abstract shortened by UMI.)