Gene-Environment Interactions Relevant to Estrogen and Risk of Breast Cancer: Can Gene-Environment Interactions Be Detected Only among Candidate SNPs from Genome-Wide Association Studies?
Creators: name: Park, JooYong
name: Choi, Ji-Yeob
name: Choi, Jaesung
name: Chung, Seokang
name: Song, Nan
name: Park, Sue K.
name: Han, Wonshik
name: Noh, Dong-Young
name: Ahn, Sei-Hyun
name: Lee, Jong Won
name: Kim, Mi Kyung
name: Jee, Sun Ha
name: Wen, Wanqing
name: Bolla, Manjeet K.
name: Wang, Qin
name: Dennis, Joe
name: Michailidou, Kyriaki
name: Shah, Mitul
name: Conroy, Don M.
name: Harrington, Patricia A.
name: Mayes, Rebecca
name: Czene, Kamila
name: Hall, Per
name: Teras, Lauren R.
name: Patel, Alpa V.
name: Couch, Fergus J.
name: Olson, Janet E.
name: Sawyer, Elinor J.
name: Roylance, Rebecca
name: Bojesen, Stig E.
name: Flyger, Henrik
name: Lambrechts, Diether
name: Baten, Adinda
name: Matsuo, Keitaro
name: Ito, Hidemi
name: Guénel, Pascal
name: Truong, Thérèse
name: Keeman, Renske
name: Schmidt, Marjanka K.
name: Wu, Anna H.
name: Tseng, Chiu-Chen
name: Cox, Angela
name: Cross, Simon S.
name: KConFab Investigators, KConFab Investigators
name: Andrulis, Irene L.
name: Hopper, John L.
name: Southey, Melissa C.
name: Wu, Pei-Ei
name: Shen, Chen-Yang
name: Fasching, Peter A.
name: Ekici, Arif B.
name: Muir, Kenneth
name: Lophatananon, Artitaya
name: Brenner, Hermann
name: Arndt, Volker
name: Jones, Michael E.
name: Swerdlow, Anthony J.
name: Hoppe, Reiner
name: Ko, Yon-Dschun
name: Hartman, Mikael
name: Li, Jingmei
name: Mannermaa, Arto
name: Hartikainen, Jaana M.
name: Benitez, Javier
name: González-Neira, Anna
name: Haiman, Christopher A.
name: Dörk, Thilo
name: Bogdanova, Natalia V.
name: Teo, Soo Hwang
name: Mohd Taib, Nur Aishah
name: Fletcher, Olivia
name: Johnson, Nichola
name: Grip, Mervi
name: Winqvist, Robert
name: Blomqvist, Carl
name: Nevanlinna, Heli
name: Lindblom, Annika
name: Wendt, Camilla
name: Kristensen, Vessela N.
name: NBCS Collaborators, NBCS Collaborators
name: Tollenaar, Rob A. E. M.
name: Heemskerk-Gerritsen, Bernadette A. M.
name: Radice, Paolo
name: Bonanni, Bernardo
name: Hamann, Ute
name: Manoochehri, Mehdi
name: Lacey, James V.
name: Martinez, Maria Elena
name: Dunning, Alison M.
name: Pharoah, Paul D. P.
name: Easton, Douglas F.
name: Yoo, Keun-Young
name: Kang, Daehee
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: breast cancer
estrogen
gene-environment interaction

description: In this study we aim to examine gene–environment interactions (GxEs) between genes involved with estrogen metabolism and environmental factors related to estrogen exposure. GxE analyses were conducted with 1970 Korean breast cancer cases and 2052 controls in the case-control study, the Seoul Breast Cancer Study (SEBCS). A total of 11,555 SNPs from the 137 candidate genes were included in the GxE analyses with eight established environmental factors. A replication test was conducted by using an independent population from the Breast Cancer Association Consortium (BCAC), with 62,485 Europeans and 9047 Asians. The GxE tests were performed by using two-step methods in GxEScan software. Two interactions were found in the SEBCS. The first interaction was shown between rs13035764 of NCOA1 and age at menarche in the GE|2df model (p-2df = 1.2 × 10−3). The age at menarche before 14 years old was associated with the high risk of breast cancer, and the risk was higher when subjects had homozygous minor allele G. The second GxE was shown between rs851998 near ESR1 and height in the GE|2df model (p-2df = 1.1 × 10−4). Height taller than 160 cm was associated with a high risk of breast cancer, and the risk increased when the minor allele was added. The findings were not replicated in the BCAC. These results would suggest specificity in Koreans for breast cancer risk.