cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Severe Refractory Paraneoplastic Mucous Membrane Pemphigoid Successfully Treated With Rituximab
Creators: name: Wittenberg, Marcel
name: Worm, Margitta
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: mucous membrane pemphigoid
subject: rituxmab
subject: paraneoplastic
subject: laminin 332
subject: therapy refractoriness
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Mucous membrane pemphigoid (MMP) is a rare autoimmune bullous disease of the mucous membranes, which can cause irreversible scarring and is discussed to be associated with cancer, if laminin-332-autoantibodies are present. MMP with severe ocular and laryngeal involvement is difficult to treat and can be treatment-refractory to conventional immunosuppressant therapy. A 67-year-old man with a history of prostate cancer presented to our clinic with sore throat, intraoral bullae, odynophagia, dysphonia, exertional dyspnea, and erosions of the glans penis. Clinical examination confirmed a laryngo-pharyngitis with involvement of the epiglottis and bilateral symblepharon. Diagnostics comprising multiple biopsies, direct and indirect immunofluorescence, serology analysis, and immunoblotting confirmed the diagnosis of a paraneoplastic MMP by showing a subepithelial split in histology and the presence of anti-laminin-332-antibodies. Despite combined systemic treatment with prednisolone and either dapsone or azathioprine, a progress of the disease occurred leading to severe ocular and laryngeal complications. Two month after rituximab treatment, complete disease control was achieved. This case report shows a severe ocular and life threatening laryngeal involvement of therapy-refractory paraneoplastic MMP highlighting the importance of interdisciplinary management and difficulty of diagnosing MMP despite repeated diagnostic testing.
Full-State Quantum Circuit Simulation by Using Data Compression
Creators: name: Wu, Xin-Chuan
name: Di, Sheng
name: Dasgupta, Emma Maitreyee
name: Cappello, Franck
name: Finkel, Hal
name: Alexeev, Yuri
name: Chong, Frederic T.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum circuit simulations are critical for evaluating quantum algorithms and machines. However, the number of state amplitudes required for full simulation increases exponentially with the number of qubits. In this study, we leverage data compression to reduce memory requirements, trading computation time and fidelity for memory space. Specifically, we develop a hybrid solution by combining the lossless compression and our tailored lossy compression method with adaptive error bounds at each timestep of the simulation. Our approach optimizes for compression speed and makes sure that errors due to lossy compression are uncorrelated, an important property for comparing simulation output with physical machines. Experiments show that our approach reduces the memory requirement of simulating the 61-qubit Grover's search algorithm from 32 exabytes to 768 terabytes of memory on Argonne's Theta supercomputer using 4,096 nodes. The results suggest that our techniques can increase the simulation size by 2 to 16 qubits for general quantum circuits.
description: Published in SC2019. Please cite the SC version
Two phases of the noncommutative quantum mechanics
Creators: name: Bellucci, Stefano
name: Nersessian, Armen
name: Sochichiu, Corneliu
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We consider quantum mechanics on the noncommutative plane in the presence of magnetic field $B$. We show, that the model has two essentially different phases separated by the point $Bθ=c\hbar^2/e$, where $θ$ is a parameter of noncommutativity. In this point the system reduces to exactly-solvable one-dimensional system. When $κ=1-eBθ/c\hbar^2<0$ there is a finite number of states corresponding to the given value of the angular momentum. In another phase, i.e. when $κ>0$ the number of states is infinite. The perturbative spectrum near the critical point $κ=0$ is computed.
description: 4 pages, presentation still improved, mistakes corrected, new sections added
MOESM8 of Genome sequencing of evolved aspergilli populations reveals robust genomes, transversions in A. flavus, and sexual aberrancy in non-homologous end-joining mutants
Creators: name: Álvarez-Escribano, Isidro
name: Sasse, Christoph
name: Bok, Jin
name: Hyunsoo Na
name: Amirebrahimi, Mojgan
name: Lipzen, Anna
name: Schackwitz, Wendy
name: Martin, Joel
name: Barry, Kerrie
name: Gutiérrez, Gabriel
name: Cea-Sánchez, Sara
name: Marcos, Ana
name: Grigoriev, Igor
name: Keller, Nancy
name: Braus, Gerhard
name: Cánovas, David
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 8: Table S4 Genes mutated during the sexual MA experiment in A. nidulans.
Correlation functions of disorder operators in massive ghost theories
Creators: name: Delfino, G.
name: Mosconi, P.
name: Mussardo, G.
Publisher: name: arXiv
Year: 2002
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: The two-dimensional ghost systems with negative integral central charge received much attention in the last years for their role in a number of applications and in connection with logarithmic conformal field theory. We consider the free massive bosonic and fermionic ghost systems and concentrate on the non-trivial sectors containing the disorder operators. A unified analysis of the correlation functions of such operators can be performed for ghosts and ordinary complex bosons and fermions. It turns out that these correlators depend only on the statistics although the scaling dimensions of the disorder operators change when going from the ordinary to the ghost case. As known from the study of the ordinary case, the bosonic and fermionic correlation functions are the inverse of each other and are exactly expressible through the solution of a non-linear differential equation.
description: 8 pages, latex
MOESM6 of Genome sequencing of evolved aspergilli populations reveals robust genomes, transversions in A. flavus, and sexual aberrancy in non-homologous end-joining mutants
Creators: name: Álvarez-Escribano, Isidro
name: Sasse, Christoph
name: Bok, Jin
name: Hyunsoo Na
name: Amirebrahimi, Mojgan
name: Lipzen, Anna
name: Schackwitz, Wendy
name: Martin, Joel
name: Barry, Kerrie
name: Gutiérrez, Gabriel
name: Cea-Sánchez, Sara
name: Marcos, Ana
name: Grigoriev, Igor
name: Keller, Nancy
name: Braus, Gerhard
name: Cánovas, David
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 6: Table S2. Genes mutated during the MA experiment in A. fumigatus.
Supreme Court of India and High Courts- Principles of inter-se Judicial Relationship
Creators: name: Prof. Anuj Kumar Vaksha
Publisher: name: figshare
Year: 2021
Subjects: subject: 180108 Constitutional Law
subject: FOS: Law

description: The essay titled Supreme Court of India and High Courts- Principles of inter-se Judicial Relationship seeks to explore and highlight the dimensions of inter-se relationship between the Supreme Court of India and the High Courts of the various States. How are the Supreme Court of India and High Courts related inter-se judicially? One generally cited answer is that, in a unified, non-federated juridical structure of the Indian judiciary, it is essentially hierarchical relationship in which the Supreme Court is at the top, and all High Courts are subordinate to each other. The interrelationship between various High Courts is that of non-hierarchical order and coordinate in nature. This description of the inter-se relationship between the Supreme Court and the High Courts is correct but not complete. The need for emphasizing the other non-hierarchical inter-se relationship between these two institutions of higher judiciary in India comes particularly from the recent controversy involving the suo motu action by the Supreme Court to take cognizance of the reported medical oxygen scarcity in various states in the wake of second wave of Corona-19 pandemic in the country.
Flexible quantum tokens in spacetime
Creators: name: Kent, Adrian
name: Pitalúa-García, Damián
Publisher: name: arXiv
Year: 2019
Subjects: subject: Quantum Physics (quant-ph)
subject: Cryptography and Security (cs.CR)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: S-money [Proc. R. Soc. A 475, 20190170 (2019)] schemes define virtual tokens designed for networks with relativistic or other trusted signalling constraints. The tokens allow near-instant verification and guarantee unforgeability without requiring quantum state storage. We present refined two stage S-money schemes. The first stage, which may involve quantum information exchange, generates private user token data. In the second stage, which need only involve classical communications, users determine the valid presentation point, without revealing it to the issuer. This refinement allows the user to determine the presentation point anywhere in the causal past of all valid presentation points. It also allows flexible transfer of tokens among users without compromising user privacy.
description: Accepted manuscript. To appear in Physical Review A
Oxazole-Bridged Combretastatin A-4 Derivatives with Tethered Hydroxamic Acids: Structure-Activity Relations of New Inhibitors of HDAC and/or Tubulin Function
Creators: name: Schmitt, Florian
name: Gosch, Lisa Chiara
name: Dittmer, Alexandra
name: Rothemund, Matthias
name: Mueller, Thomas
name: Schobert, Rainer
name: Biersack, Bernhard
name: Volkamer, Andrea
name: Höpfner, Michael
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: combretastatin A-4
subject: oxazole
subject: histone deacetylase
subject: tubulin
subject: anticancer agents
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: New inhibitors of tubulin polymerization and/or histone deacetylase (HDAC) activity were synthesized by attaching alkyl tethered hydroxamic acid appendages of varying length to oxazole-bridged combretastatin A-4 analogous caps. While their antiproliferative and microtubule disrupting effect was most pronounced for derivatives with short spacers, HDAC inhibition was strongest for those with longer spacers. These findings were further supported by computational methods such as structure-based docking experiments exploring the target interactions of the derivatives with varying linkers. For instance, compounds featuring short four-atom spacers between cap and hydroxamic acid inhibited the growth of various cancer cell lines and human endothelial hybrid cells with IC50 values in the low nanomolar range. In line with their ability to inhibit the microtubule assembly, four- and five-atom spacered hydroxamic acids caused an accumulation of 518A2 melanoma cells in G2/M phase, whereas a compound featuring a six-atom spacer and performing best in HDAC inhibition, induced a G1 arrest in these cells. All these beneficial anticancer activities together with their selectivity for cancer cells over non-malignant cells, point out the great potential of these novel pleiotropic HDAC and tubulin inhibitors as drug candidates for cancer therapy.
Open System Tensor Networks and Kramers' Crossover for Quantum Transport
Creators: name: Wojtowicz, Gabriela
name: Elenewski, Justin E.
name: Rams, Marek M.
name: Zwolak, Michael
Publisher: name: arXiv
Year: 2019
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Tensor networks are a powerful tool for many-body ground states with limited entanglement. These methods can nonetheless fail for certain time-dependent processes - such as quantum transport or quenches - where entanglement growth is linear in time. Matrix-product-state decompositions of the resulting out-of-equilibrium states require a bond dimension that grows exponentially, imposing a hard limit on simulation timescales. However, in the case of transport, if the reservoir modes of a closed system are arranged according to their scattering structure, the entanglement growth can be made logarithmic. Here, we apply this ansatz to open systems via extended reservoirs that have explicit relaxation. This enables transport calculations that can access steady states, time dynamics and noise, and periodic driving (e.g., Floquet states). We demonstrate the approach by calculating the transport characteristics of an open, interacting system. These results open a path to scalable and numerically systematic many-body transport calculations with tensor networks.
description: 7 pages, 4 figures
Metric-affine approach to teleparallel gravity
Creators: name: Obukhov, Yu. N.
name: Pereira, J. G.
Publisher: name: arXiv
Year: 2002
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The teleparallel gravity theory, treated physically as a gauge theory of translations, naturally represents a particular case of the most general gauge-theoretic model based on the general affine group of spacetime. On the other hand, geometrically, the Weitzenboeck spacetime of distant parallelism is a particular case of the general metric-affine spacetime manifold. These physical and geometrical facts offer a new approach to the teleparallelism. We present a systematic treatment of the teleparallel gravity within the framework of the metric-affine theory. The symmetries, conservation laws and the field equations are consistently derived, and the physical consequences are discussed in detail. We demonstrate that the so-called teleparallel GR-equivalent model has a number of attractive features which distinguishes it among the general teleparallel theories, although it has a consistency problem when dealing with spinning matter sources.
description: Revtex4, 22 pages, no figures. Accepted for publication in Phys. Rev. D
What’s wrong with being an agricultural economy?
Creators: name: Rae, Allan N.
name: Rae, Allan N.
Publisher: name: Unknown
Year: 2014
Subjects: Agribusiness
Financial Economics

description: Commentators have suggested over the years, and still do, that the NZ economy should restructure more rapidly towards sophisticated manufacturing and services so as to avoid remaining an agricultural economy. This paper reviews some relevant theory and empirical analyses, in a search for evidence that agricultural economies grow more slowly than others and for approaches that may be helpful for further research. The evidence is mixed, but appears not to strongly support the hypothesis that NZ would grow faster through a lesser focus on agriculture.
Closed expressions for the nuclear moments in semi-leptonic processes
Creators: name: Chasioti, V. Ch.
name: Kosmas, T. S.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We discuss a general formalism needed for a unified description of the weak and electromagnetic processes in nuclei which is based on the multipole decomposition of the hadronic currents. The use of harmonic oscillator single-particle basis, which is commonly employed in many-body nuclear calculations, simplifies the relevant expressions. We present analytic formulas for the corresponding radial integrals which enter the transition matrix elements of one-body operators in various semi-leptonic nuclear processes. As an example, we apply our formalism in order to simplify previous formalism giving the nuclear moments for the $0νββ$ - decay. Our results for the radial integrals refer to the 1s-0d-1p-0f model space.
description: 12 Latex pages, 3 Tables, 16 Refs. Czech. J. Phys., to appear
Endogenous oxytocin response to film scenes of attachment and loss is pronounced in schizophrenia
Creators: name: Speck, Lucas G.
name: Schöner, Johanna
name: Bermpohl, Felix
name: Heinz, Andreas
name: Gallinat, Jürgen
name: Majić, Tomislav
name: Montag, Christiane
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: schizophrenia
subject: oxytocin
subject: emotion induction
subject: attachment
subject: trauma
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Oxytocin (OXT) is critically involved in the regulation of attachment and interpersonal function. In this study, emotional childrens movies were used to stimulate OXT secretion in patients with schizophrenia and healthy controls (HCs). Furthermore, associations of OXT levels with measures of attachment style (Psychosis Attachment Measure), childhood adversity (Childhood Trauma Questionnaire) and symptom severity [Positive and Negative Syndrome Scale (PANSS)] were considered. In 35 patients with schizophrenia and 35 matched HCs, radioimmunoassay with sample extraction was used to determine OXT plasma levels before and after viewing of movie scenes portraying emotional bonding and loss and compared to a non-emotional condition. Statistical analysis indicated lower baseline OXT levels in female patients than in all other groups. OXT reactivity during emotional movies was significantly higher in patients when compared to HCs. OXT reactivity during the control movie related to PANSS `general psychopathology. No significant associations appeared between baseline or induced OXT levels and other PANSS subscales, attachment style or childhood adversity in patients. Our findings suggest differences of baseline OXT and a higher OXT reactivity toward strong emotional stimuli in patients with schizophrenia, suggesting a role of OXT as a gender- and context-dependent modulator of socio-emotional function.
Ketogenic diets attenuate cyclooxygenase and lipoxygenase gene expression in multiple sclerosis
Creators: name: Bock, Markus
name: Karber, Mirjam
name: Kuhn, Hartmut
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: Multiple Sclerosis
subject: Adapted Ketogenic Diet
subject: Caloric Restriction
subject: Lipoxygenase
subject: Cyclooxygenase
subject: Multiple Sclerosis Quality of Life-54 Instrument (MSQOL-54)
subject: Eosinophils
subject: Basophils
subject: Inflammation
subject: Neuroprotection
subject: Eicosanoids
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Adapted ketogenic diet (AKD) and caloric restriction (CR) have been suggested as alternative therapeutic strategies for inflammatory, hyperproliferative and neurodegenerative diseases. Pro-inflammatory eicosanoids have been implicated in the pathogenesis of multiple sclerosis since they augment vascular permeability and induce leukocyte migration into the brain. We explored the impact of ketogenic diets on gene expression of biosynthetic enzymes for pro- (ALOX5, COX1, COX2) and anti-inflammatory (ALOX15) eicosanoids in patients with relapsing-remitting multiple sclerosis. Methods: 60 adults were prospectively recruited for this six months randomized controlled trial and the impact of dietary treatment on the Multiple Sclerosis Quality of Life-54 index (ClinicalTrials.gov (NCT01538355) has previously been published. Here we explored 24 patients (8 controls, 5 on CR and 11 on AKD). For statistical analysis we combined the two diet groups to a single pooled treatment group. Findings: Inter-group comparison indicated that expression of the pro-inflammatory ALOX5 in the pooled treatment group was significantly (p <0.05) reduced when compared with the control group. Moreover, intra-group comparison (same individuals before and after dietary treatment) suggested significantly impaired expression of other pro-inflammatory enzymes, such as COX1 (p < 0.001) and COX2 ( p < 0.05). Finally, pretreatment cross-group analysis revealed a significant positive correlation between expression of pro-inflammatory ALOX5 and COX2 and an inverse correlation of ALOX5 and COX1 expression with the MSQoL-54 index. Interpretation: Ketogenic diets can reduce the expression of enzymes involved in the biosynthesis of pro-inflammatory eicosanoids. Pharmacological interference with eicosanoid biosynthesis might constitute a strategy supplementing current therapeutic approaches for MS. (C) 2018 The Authors. Published by Elsevier B.V.
Identification of a novel compound that simultaneously impairs the ubiquitin-proteasome system and autophagy
Creators: name: Giovannucci, Tatiana A.
name: Salomons, Florian A.
name: Stoy, Henriette
name: Herzog, Laura K.
name: Xu, Shanshan
name: Qian, Weixing
name: Merino, Lara G.
name: Gierisch, Maria E.
name: Haraldsson, Martin
name: Lystad, Alf H.
name: Uvell, Hanna
name: Simonsen, Anne
name: Gustavsson, Anna-Lena
name: Vallin, Michaela
name: Dantuma, Nico P.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: The ubiquitin-proteasome system (UPS) and macroautophagy/autophagy are the main proteolytic systems in eukaryotic cells for preserving protein homeostasis, i.e., proteostasis. By facilitating the timely destruction of aberrant proteins, these complementary pathways keep the intracellular environment free of inherently toxic protein aggregates. Chemical interference with the UPS or autophagy has emerged as a viable strategy for therapeutically targeting malignant cells which, owing to their hyperactive state, heavily rely on the sanitizing activity of these proteolytic systems. Here, we report on the discovery of CBK79, a novel compound that impairs both protein degradation by the UPS and autophagy. While CBK79 was identified in a high-content screen for drug-like molecules that inhibit the UPS, subsequent analysis revealed that this compound also compromises autophagic degradation of long-lived proteins. We show that CBK79 induces non-canonical lipidation of MAP1LC3B/LC3B (microtubule-associated protein 1 light chain 3 beta) that requires ATG16L1 but is independent of the ULK1 (unc-51 like autophagy activating kinase 1) and class III phosphatidylinositol 3-kinase (PtdIns3K) complexes. Thermal preconditioning of cells prevented CBK79-induced UPS impairment but failed to restore autophagy, indicating that activation of stress responses does not allow cells to bypass the inhibitory effect of CBK79 on autophagy. The identification of a small molecule that simultaneously impairs the two main proteolytic systems for protein quality control provides a starting point for the development of a novel class of proteostasis-targeting drugs.
Shape invariance, raising and lowering operators in hypergeometric type equations
Creators: name: Cotfas, N.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The Schr\" odinger equations which are exactly solvable in terms of associated special functions are directly related to some self-adjoint operators defined in the theory of hypergeometric type equations. The fundamental formulae occurring in a supersymmetric approach to these Hamiltonians are consequences of some formulae concerning the general theory of associated special functions. We use this connection in order to obtain a general theory of Schr\" odinger equations exactly solvable in terms of associated special functions, and to extend certain results known in the case of some particular potentials.
description: LaTeX 2.09, 11 pages, IOP style (Bristol), All is included in only one .tex file, Please use for reply my e-address: ncotfas@yahoo.com
Hazards to avoid in future neonatal studies of nasal high‑frequency oscillatory ventilation: lessons from an early terminated trial
Creators: name: Fischer, Hendrik S.
name: Bührer, Christoph
name: Czernik, Christoph
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: Extubation
subject: High-frequency ventilation
subject: Hypercapnia
subject: Nasal continuous positive airway pressure
subject: Premature infant
subject: Randomised controlled trial
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: OBJECTIVE: To investigate whether nasal high-frequency oscillatory ventilation (nHFOV) started immediately after extubation of mechanically ventilated very low birth weight infants reduces the partial pressure of carbon dioxide at 72 h after extubation in comparison with nasal continuous positive airway pressure. This randomised controlled single-centre trial aimed to include 68 preterm infants at high risk of extubation failure. RESULTS: Implementation of the study protocol was feasible. However, from 2015 to 2017, only six patients could be recruited, leading to early termination of the trial. The slow recruitment was due to the introduction of new strategies to avoid endotracheal mechanical ventilation, which reduced the number of eligible infants. Moreover, the included infants failed their extubation more often than anticipated, thereby increasing the required sample size. Based on our single-centre experience, we provide information for study planning and discuss the specific requirements for future trial protocols on nHFOV. The extubation of high-risk infants into nHFOV could well be beneficial, but a multicentric approach is necessary to investigate this hypothesis. Trial Registration Clinicaltrials.gov NCT02340299, on 16 January 2015.
Interface energies in Ising spin glasses
Creators: name: Aspelmeier, T.
name: Moore, M. A.
name: Young, A. P.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: The replica method has been used to calculate the interface free energy associated with the change from periodic to anti-periodic boundary conditions in finite-dimensional spin glasses. At mean-field level the interface free energy vanishes but after allowing for fluctuation effects, a non-zero interface free energy is obtained which is significantly different from numerical expectations.
description: 4 pages. Minor changes and clarifications
IL-33 and MRGPRX2-Triggered Activation of Human Skin Mast Cells—Elimination of Receptor Expression on Chronic Exposure, but Reinforced Degranulation on Acute Priming
Creators: name: Wang, Zhao
name: Guhl, Sven
name: Franke, Kristin
name: Artuc, Metin
name: Zuberbier, Torsten
name: Babina, Magda
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: IL-33
subject: JNK
subject: MRGPRX2
subject: degranulation
subject: mast cells
subject: neurogenic mast cell activation
subject: neuropeptides
subject: p38
subject: pseudo-allergy
subject: skin
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Clinically relevant exocytosis of mast cell (MC) mediators can be triggered by high-affinity IgE receptor (FcεRI)-aggregation (allergic route) or by the so-called pseudo-allergic pathway elicited via MAS-related G protein-coupled receptor-X2 (MRGPRX2). The latter is activated by drugs and endogenous neuropeptides. We recently reported that FcεRI-triggered degranulation is attenuated when human skin mast cells are chronically exposed to IL-33. Here, we were interested in the regulation of the MRGPRX2-route. Chronic exposure of skin MCs to IL-33 basically eliminated the pseudo-allergic/neurogenic route as a result of massive MRGPRX2 reduction. This downregulation seemed to partially require c-Jun N-terminal Kinase (JNK), but not p38, the two kinases activated by IL-33 in skin MCs. Surprisingly, however, JNK had a positive effect on MRGPRX2 expression in the absence of IL-33. This was evidenced by Accell®-mediated JNK knockdown and JNK inhibition. In stark contrast to the dampening effect upon prolonged exposure, IL-33 was able to prime for increased degranulation by MRGPRX2 ligands when administered directly before stimulation. This supportive effect depended on p38, but not on JNK activity. Our data reinforce the concept that exposure length dictates whether IL-33 will enhance or attenuate secretion. IL-33 is, thus, the first factor to acutely enhance MRGPRX2-triggered degranulation. Finally, we reveal that p38, rarely associated with MC degranulation, can positively affect exocytosis in a context-dependent manner.
Generalization of the U_q(gl(N)) algebra and staggered models
Creators: name: Arnaudon, D.
name: Sedrakyan, A.
name: Sedrakyan, T.
name: Sorba, P.
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We develop a technique of construction of integrable models with a Z_2 grading of both the auxiliary (chain) and quantum (time) spaces. These models have a staggered disposition of the anisotropy parameter. The corresponding Yang-Baxter Equations are written down and their solution for the gl(N) case are found. We analyze in details the N=2 case and find the corresponding quantum group behind this solution. It can be regarded as quantum U_{q,B}(gl(2)) group with a matrix deformation parameter qB with (qB)^2=q^2. The symmetry behind these models can also be interpreted as the tensor product of the (-1)-Weyl algebra by an extension of U_q(gl(N)) with a Cartan generator related to deformation parameter -1.
description: 12 pages ; Latex2e
Australia’s new Free Trade Agreements with Japan and South Korea: Potential Impacts on the Resources and Agricultural Sectors and their Environmental Implications
Creators: name: Siriwardana, Mahinda
name: Siriwardana, Mahinda
Publisher: name: Unknown
Year: 2014
Subjects: subject: International Relations/Trade
subject: Free Trade Agreement
subject: Australia
subject: GTAP-E model
subject: Emissions
subject: Emissions Trading Scheme

description: This paper examines both economic and environmental impacts of the two new free trade agreements (FTAs) that Australia has recently negotiated with Japan and South Korea using the GTAP-E general equilibrium model. We analyse two trade policy scenarios: first a ‘Free trade scenario’ where bilateral tariffs are eliminated between Australia and Japan, and Australia and South Korea; second a ‘Green trade scenario’ where the ‘Free trade scenario’ is complemented by an environmental policy using an emissions trading scheme (ETS). The results indicate that two trade agreements enhance Australia’s trade at a modest expense on the environment. The paper illustrates that an ETS between Australia, Japan and Korea is an expensive policy to mitigate emissions arising from FTAs.
Oranda tsūhaku, 1
和蘭通舶 一
Creators: name: Shiba, Kōkan, 1747?-1818
Publisher: name: Edo : Shiba Kōkan (Shunparō)
Year: 2021

description: At the end of vol.1 are two short chapters devoted to European style painting and copper engraving. Free translation of title: World geography from Dutch sources.
Quantum locking of mirrors in interferometers
Creators: name: Courty, Jean-Michel
name: Heidmann, A.
name: Pinard, M.
Publisher: name: arXiv
Year: 2002
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We show that quantum noise in very sensitive interferometric measurements such as gravitational-waves detectors can be drastically modified by quantum feedback. We present a new scheme based on active control to lock the motion of a mirror to a reference mirror at the quantum level. This simple technique allows to reduce quantum effects of radiation pressure and to greatly enhance the sensitivity of the detection.
description: 4 pages, 2 figures, RevTeX
Why and how to use a differential equation method to calculate multi-loop integrals
Creators: name: Czachor, M.
name: Czyz, H.
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: A short pedagogical introduction to a differential method used to calculate multi-loop scalar integrals is presented. As an example it is shown how to obtain, using the method, large mass expansion of the two loop sunrise master integrals.
description: 9 p., presented at XXV International Conference on Theoretical Physics "Particle Physics and Astrophysics in the Standard Models and Beyond", Ustron, Poland, September 2001
On Positive Geometry and Scattering Forms for Matter Particles
Creators: name: Herderschee, Aidan
name: He, Song
name: Teng, Fei
name: Zhang, Yong
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Combinatorics (math.CO)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We initiate the study of positive geometry and scattering forms for tree-level amplitudes with matter particles in the (anti-)fundamental representation of the color/flavor group. As a toy example, we study the bi-color scalar theory, which supplements the bi-adjoint theory with scalars in the (anti-)fundamental representations of both groups. Using a recursive construction we obtain a class of unbounded polytopes called open associahedra (or associahedra with certain facets at infinity) whose canonical form computes amplitudes in bi-color theory, for arbitrary number of legs and flavor assignments. In addition, we discuss the duality between color factors and wedge products, or "color is kinematics", for amplitudes with matter particles as well.
description: 47 pages and 9 figures; v2: more references added and typos corrected; v3: published version and typos corrected
A Taxonomic Approach to Understanding Emerging Blockchain Identity Management Systems
Creators: name: Lesavre, Loic
name: Varin, Priam
name: Mell, Peter
name: Davidson, Michael
name: Shook, James
Publisher: name: arXiv
Year: 2019
Subjects: subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences

description: Identity management systems (IDMSs) are widely used to provision user identities while managing authentication, authorization, and data sharing within organizations and on the web. Traditional identity systems typically suffer from single points of failure, lack of interoperability, and privacy issues, such as enabling mass data collection and user tracking. Blockchain technology has the potential to alleviate these concerns: it can support the ability for users to control the custody of their own identifiers and credentials, enabling novel data ownership and governance models with built-in control and consent mechanisms. Hence, blockchain-based IDMSs, which could benefit both users and businesses, are beginning to proliferate. This work categorizes these systems into a taxonomy based on differences in blockchain architectures, governance models, and other salient features. Context is provided for the taxonomy through the description of related terms, emerging standards, and use cases while highlighting relevant security and privacy considerations.
description: 62 pages, U.S. National Institute of Standards and Technology (NIST) Cybersecurity White Paper
Molecular Mechanisms of Kidney Injury and Repair in Arterial Hypertension
Creators: name: Sievers, Laura Katharina
name: Eckardt, Kai-Uwe
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: hypertension
subject: kidney
subject: molecular signaling
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The global burden of chronic kidney disease is rising. The etiologies, heterogeneous, and arterial hypertension, are key factors contributing to the development and progression of chronic kidney disease. Arterial hypertension is induced and maintained by a complex network of systemic signaling pathways, such as the hormonal axis of the renin-angiotensin-aldosterone system, hemodynamic alterations affecting blood flow, oxygen supply, and the immune system. This review summarizes the clinical and histopathological features of hypertensive kidney injury and focusses on the interplay of distinct systemic signaling pathways, which drive hypertensive kidney injury in distinct cell types of the kidney. There are several parallels between hypertension-induced molecular signaling cascades in the renal epithelial, endothelial, interstitial, and immune cells. Angiotensin II signaling via the AT1R, hypoxia induced HIFα activation and mechanotransduction are closely interacting and further triggering the adaptions of metabolism, cytoskeletal rearrangement, and profibrotic TGF signaling. The interplay of these, and other cellular pathways, is crucial to balancing the injury and repair of the kidneys and determines the progression of hypertensive kidney disease.
Analogy Making and the Structure of Implied Volatility Skew
Creators: name: Siddiqi, Hammad
name: Siddiqi, Hammad
Publisher: name: Unknown
Year: 2014
Subjects: subject: Financial Economics
subject: Implied Volatility
subject: Implied Volatility Skew
subject: Implied Volatility Smile
subject: Analogy Making
subject: Stochastic Volatility
subject: Jump Diffusion

description: An analogy based option pricing model is put forward. If option prices are determined in accordance with the analogy model, and the Black Scholes model is used to back-out implied volatility, then the implied volatility skew arises, which flattens as time to expiry increases. The analogy based stochastic volatility and the analogy based jump diffusion models are also put forward. The analogy based stochastic volatility model generates the skew even when there is no correlation between the stock price and volatility processes, whereas, the analogy based jump diffusion model does not require asymmetric jumps for generating the skew.
Phasic Left Atrial Function in Cancer Patients Before Initiation of Anti-Cancer Therapy
Creators: name: Tadic, Marijana
name: Genger, Martin
name: Cuspidi, Cesare
name: Belyavskiy, Evgeny
name: Frydas, Athanasios
name: Dordevic, Aleksandar
name: Morris, Daniel A.
name: Völkl, Jakob
name: Parwani, Abdul Shokor
name: Pieske, Burkert
name: Haßfeld, Sabine
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: cancer
subject: left atrium
subject: phasic function
subject: strain
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: We aimed to explore left atrial (LA) remodeling in the patients with solid cancer before initiation of chemo- or radiotherapy. This retrospective investigation included 92 chemo- and radiotherapy-naive cancer patients and 40 age- and gender-matched controls with a similar cardiovascular risk profile as the cancer group. All participants underwent comprehensive echocardiographic examination before the start of chemo- or radiotherapy. LA phasic function was evaluated in volumetric and strain method. Indexed minimal and pre-A LA volumes were significantly higher in the cancer patients. Total and passive LA emptying fraction (EF) were significantly lower, whereas active LAEF was significantly higher in the cancer patients. LA total longitudinal strain was significantly lower in the cancer patients. Strain rate analysis of LA phasic function showed that LA function during systole and early diastole was reduced in the cancer group, while it was increased during late diastole. These findings indicated that LA reservoir and conduit functions, assessed with LA volumetric and strain analysis, were deteriorated in the cancer group. On the other hand, LA booster pump function was elevated in the cancer group in comparison with the controls. In the whole population, cancer was associated with reduced LA total longitudinal strain independently of age, gender, BMI, LV hypertrophy, E/e’ ratio, diabetes, and hypertension. LA phasic function was impaired in the chemo- and radiotherapy-naive cancer patients in comparison with the control group. Cancer, LV hypertrophy, and hypertension were associated with reduced LA longitudinal strain independently of other important clinical parameters.
MOESM5 of Genome sequencing of evolved aspergilli populations reveals robust genomes, transversions in A. flavus, and sexual aberrancy in non-homologous end-joining mutants
Creators: name: Álvarez-Escribano, Isidro
name: Sasse, Christoph
name: Bok, Jin
name: Hyunsoo Na
name: Amirebrahimi, Mojgan
name: Lipzen, Anna
name: Schackwitz, Wendy
name: Martin, Joel
name: Barry, Kerrie
name: Gutiérrez, Gabriel
name: Cea-Sánchez, Sara
name: Marcos, Ana
name: Grigoriev, Igor
name: Keller, Nancy
name: Braus, Gerhard
name: Cánovas, David
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 5: Table S1. Genes mutated during the MA experiment in A. flavus.
Association between changes in molecular biomarkers of cartilage matrix turnover and changes in knee articular cartilage: a longitudinal pilot study
Creators: name: Boeth, Heide
name: Raffalt, Peter C.
name: MacMahon, Aoife
name: Poole, A. Robin
name: Eckstein, Felix
name: Wirth, Wolfgang
name: Buttgereit, Frank
name: Önnerfjord, Patrik
name: Lorenzo, Pilar
name: Klint, Cecilia
name: Pramhed, Anna
name: Duda, Georg N.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: Athletes
subject: Biomarkers
subject: Cartilage degradation
subject: Knee osteoarthritis
subject: Volleyball
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: An early detection of Osteoarthritis is urgently needed and still not possible until today. The aim of the study was to assess whether molecular biomarkers of cartilage turnover are associated with longitudinal change in knee cartilage thickness during a 2 year period in individuals with increased risk of developing knee osteoarthritis. A secondary aim was to assess whether prior knee injury or subjective patient-reported outcomes at baseline (BL) were associated with articular cartilage changes. Nineteen volleyball players (mean age 46.5 ± 4.9 years, 47% male) with a 30-year history of regular high impact training were recruited. The serum biomarkers Cpropeptide of type II procollagen (CPII), cartilage oligomeric matrix protein (COMP), collagenase generated carboxy-terminal neoepitope of type II collagen (sC2C), cartilage intermediate layer protein 2 (CILP-2), and the urine biomarkers Ctelopeptide of type II collagen (CTX-II) and collagenase-generated peptide(s) of type II collagen (C2C-HUSA) were assessed at BL and at 2 year follow up (FU). Femorotibial cartilage thinning, thickening and absolute thickness change between BL and FU was evaluated from magnetic resonance imaging. Subjective clinical status at BL was evaluated by the International Knee Documentation Committee Subjective Knee Form and the Short-Form 36 Physical Component Score. Results: CILP-2 was significantly higher at FU and linearly associated with the absolute cartilage thickness change during the experimental period. Prior injury was a predictor of increased absolute cartilage thickness change. Conclusion: Measuring the change in the cartilage biomarker CILP-2 might be a valid and sensitive method to detect early development of knee osteoarthritis as CILP-2 appears to be related to cartilage thickness loss in certain individuals with increased risk of developing knee osteoarthritis. Prior knee injury may be predictive of increased articular cartilage thickness change.
Testing for universality of Mendeley readership distributions
Creators: name: D'Angelo, Ciriaco Andrea
name: Di Russo, Samuele
Publisher: name: arXiv
Year: 2019
Subjects: subject: Digital Libraries (cs.DL)
subject: FOS: Computer and information sciences

description: Altmetrics promise useful support for assessing the impact of scientific works, including beyond the scholarly community and with very limited citation windows. Unfortunately, altmetrics scores are currently available only for recent articles and cannot be used as covariates in predicting long term impact of publications. However, the study of their statistical properties is a subject of evident interest to scientometricians. Applying the same approaches used in the literature to assess the universality of citation distributions, the intention here is to test whether the universal distribution also holds for Mendeley readerships. Results of the analysis carried out on a sample of publications randomly extracted from the Web of Science confirm that readerships seem to share similar shapes across fields and can be rescaled to a common and universal form. Such rescaling results as not particularly effective on the right tails. In other regions, rescaling causes a good collapse of field specific distributions, even for very recent publications.
Trapped-Ion Quantum Logic Utilizing Position-Dependent ac Stark Shifts
Creators: name: Staanum, Peter
name: Drewsen, Michael
Publisher: name: arXiv
Year: 2002
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present a scheme utilizing position-dependent ac Stark shifts for doing quantum logic with trapped ions. By a proper choice of direction, position and size, as well as power and frequency of a far-off-resonant Gaussian laser beam, specific ac Stark shifts can be assigned to the individual ions, making them distinguishable in frequency-space. In contrast to previous all-optical based quantum gates with trapped ions, the present scheme enables individual addressing of single ions and selective addressing of any pair of ions for two-ion quantum gates, without using tightly focused laser beams. Furthermore, the decoherence rate due to off-resonant excitations can be made negligible as compared with other sources of decoherence.
description: 5 pages, 4 figures. Submitted to Physical Review Letters