cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Pre-hypertension: another ‘pseudodisease’?
Creators: name: Meier, Pascal
name: Messerli, Franz H.
name: Baumbach, Andreas
name: Lansky, Alexandra
Publisher: name: Columbia University
Year: 2013
Subjects: Cardiovascular system--Diseases
Hypertension
Medicine
Medical sciences

description: Hypertension is one of the most important and common cardiovascular risk factors. Defining the level at which blood pressure starts causing end-organ damage is challenging, and is not easily answered. The threshold of blood pressure defining hypertension has progressively been reduced over time, from systolic >160 mmHg to >150 mmHg, then to >140 mmHg; and now even blood pressures above 130 to 120 mmHg are labeled as ‘pre-hypertension’ by some expert committees. Are interest groups creating another ‘pseudodisease’ or is this trend scientifically justified? A recent meta-analysis published in BMC Medicine by Huang et al. clearly indicates that pre-hypertension (120 to 140/80 to 90 mmHg) is a significant marker of increased cardiovascular risk. This raises the question as to whether we now need to lower the threshold of ‘hypertension’ (as opposed to ‘pre-hypertension’) to >120/80 mmHg, redefining a significant proportion of currently healthy people as ‘patients’ with an established disease. These data need to be interpreted with some caution. It is controversial whether pre-hypertension is an independent risk factor or just a risk marker and even more controversial whether treatment of pre-hypertension will lower cardiovascular risk.
Distinct genotypic profiles of the two major clades of Mycobacterium africanum
Creators: name: Vasconcellos, Sidra
name: Huard, Richard C.
name: Niemann, Stefan
name: Kremer, Kristin
name: Santos, Adalberto
name: Suffys, Philip
name: Ho, John
Publisher: name: Columbia University
Year: 2010
Subjects: subject: Tuberculosis
subject: Epidemiology
subject: Genetics
subject: FOS: Biological sciences

description: Background:
Mycobacterium tuberculosis is the principal etiologic agent of human tuberculosis (TB) and a member of the M. tuberculosis complex (MTC). Additional MTC species that cause TB in humans and other mammals include Mycobacterium africanum and Mycobacterium bovis. One result of studies interrogating recently identified MTC phylogenetic markers has been the recognition of at least two distinct lineages of M. africanum, known as West African-1 and West African-2. Methods: We screened a blinded non-random set of MTC strains isolated from TB patients in Ghana (n = 47) for known chromosomal region-of-difference (RD) loci and single nucleotide polymorphisms (SNPs). A MTC PCR-typing panel, single-target standard PCR, multi-primer PCR, PCR-restriction fragment analysis, and sequence analysis of amplified products were among the methods utilized for the comparative evaluation of targets and identification systems. The MTC distributions of novel SNPs were characterized in the both the Ghana collection and two other diverse collections of MTC strains (n = 175 in total). Results: The utility of various polymorphisms as species-, lineage-, and sublineage-defining phylogenetic markers for M. africanum was determined. Novel SNPs were also identified and found to be specific to either M. africanum West African-1 (Rv1332 523; n = 32) or M. africanum West African-2 (nat
751; n = 27). In the final analysis, a strain identification approach that combined multi-primer PCR targeting of the RD loci RD9, RD10, and RD702 was the most simple, straight-forward, and definitive means of distinguishing the two clades of M. africanum from one another and from other MTC species. Conclusion: With this study, we have organized a series of consistent phylogenetically-relevant markers for each of the distinct MTC lineages that share the M. africanum designation. A differential distribution of each M. africanum clade in Western Africa is described.
The Oct1 homolog Nubbin is a repressor of NF-κB-dependent immune gene expression that increases the tolerance to gut microbiota
Creators: name: Dantoft, Widad
name: Davis, Monica
name: Lindvall, Jessica
name: Tang, Xiongzhuo
name: Uvell, Hanna
name: Junell, Anna
name: Beskow, Anne Christina
name: Engström, Ylva
Publisher: name: Columbia University
Year: 2013
Subjects: subject: Drosophila
subject: Genetic regulation
subject: Biology
subject: Genetics
subject: FOS: Biological sciences

description: Background: Innate immune responses are evolutionarily conserved processes that provide crucial protection against invading organisms. Gene activation by potent NF-κB transcription factors is essential both in mammals and Drosophila during infection and stress challenges. If not strictly controlled, this potent defense system can activate autoimmune and inflammatory stress reactions, with deleterious consequences for the organism. Negative regulation to prevent gene activation in healthy organisms, in the presence of the commensal gut flora, is however not well understood. Results: We show that the Drosophila homolog of mammalian Oct1/POU2F1 transcription factor, called Nubbin (Nub), is a repressor of NF-κB/Relish-driven antimicrobial peptide gene expression in flies. In nub mutants, which lack Nub-PD protein, excessive expression of antimicrobial peptide genes occurs in the absence of infection, leading to a significant reduction of the numbers of cultivatable gut commensal bacteria. This aberrant immune gene expression was effectively blocked by expression of Nub from a transgene. We have identified an upstream regulatory region, containing a cluster of octamer sites, which is required for repression of antimicrobial peptide gene expression in healthy flies. Chromatin immunoprecipitation experiments demonstrated that Nub binds to octamer-containing promoter fragments of several immune genes. Gene expression profiling revealed that Drosophila Nub negatively regulates many genes that are involved in immune and stress responses, while it is a positive regulator of genes involved in differentiation and metabolism. Conclusions: This study demonstrates that a large number of genes that are activated by NF-κB/Relish in response to infection are normally repressed by the evolutionarily conserved Oct/POU transcription factor Nub. This prevents uncontrolled gene activation and supports the existence of a normal gut flora. We suggest that Nub protein plays an ancient role, shared with mammalian Oct/POU transcription factors, to moderate responses to immune challenge, thereby increasing the tolerance to biotic stress.
Epstein-Barr virus myelitis and Castleman's disease in a patient with acquired immune deficiency syndrome: a case report
Creators: name: Albany, Costantine
name: Psevdos, George
name: Balderacchi, Jasminka
name: Sharp, Victoria L.
Publisher: name: Columbia University
Year: 2011
Subjects: Herpesvirus diseases
Epstein-Barr virus
Medicine
Public health

description: Introduction: Few cases of Epstein-Barr virus myelitis have been described in the literature. Multi-centric Castleman's disease is a lymphoproliferative disorder that is well known for its associations with the human immunodeficiency virus, human herpes virus 8, and Kaposi's sarcoma. The concurrent presentation of these two diseases in a patient at the same time is extremely unusual. Case Presentation: We describe the case of a 43-year-old Caucasian man with acquired immune deficiency syndrome who presented with fever, weight loss and diffuse lymphadenopathy, and was diagnosed with multi-centric Castleman's disease. He presented three weeks later with lower extremity weakness and urinary retention, at which time cerebrospinal fluid contained lymphocytic pleocytosis and elevated protein. Magnetic resonance imaging demonstrated abnormal spinal cord signal intensity over several cervical and thoracic segments, suggesting the diagnosis of myelitis. Our patient was ultimately diagnosed with Epstein-Barr virus myelitis, as Epstein-Barr virus DNA was detected by polymerase chain reaction in the cerebrospinal fluid. Conclusion: To the best of our knowledge, this is the first case of multi-centric Castleman's disease followed by acute Epstein-Barr virus myelitis in a human immunodeficiency virus-infected patient. Clinicians caring for human immunodeficiency virus-infected patients should be vigilant about monitoring patients with increasing lymphadenopathy, prompting thorough diagnostic investigations when necessary.
Food consumption patterns and associated factors among Vietnamese women of reproductive age
Creators: name: Nguyen, Phuong
name: Strizich, Garrett
name: Lowe, Alyssa
name: Nguyen, Hieu
name: Pham, Hoa
name: Truong, Truong
name: Nguyen, Son
name: Martorell, Reynaldo
name: Ramakrishnan, Usha
Publisher: name: Columbia University
Year: 2013
Subjects: Women--Nutrition
Public health

description: Background and objectives: Adequate nutrient intakes among women of reproductive age (WRA) are important determinants of maternal, neonatal and child health outcomes. However, data on dietary intake for WRA in Vietnam are lacking. This paper aimed to examine the adequacy and determinants of energy and macronutrient intakes among WRA enrolled in a study of preconceptual micronutrient supplementation (PRECONCEPT) being conducted in 20 rural communes in Thai Nguyen province, Vietnam. Methods: Dietary intakes were determined for 4983 WRA who participated in the baseline survey using a previously validated 107-item (semi-quantitative) food-frequency questionnaire that was administered by trained field workers. Multivariate linear and logistic regression analyses were used to examine factors associated with energy and macronutrient intakes. Results: A disproportionate number of energy came from starches, primarily rice. Carbohydrate, fat and protein constituted 65.6%, 19.5% and 14.8% of total energy, respectively. Fat intake was below recommended levels in 56.5% of respondents, but carbohydrate intakes were above recommended level in 54.6%. Only 0.1% and 5.2% of WRA achieved adequate intake of n-3 and n-6 long-chain polyunsaturated fatty acids, respectively. Multivariate linear regression revealed that low education, low socioeconomic status, and food insecurity were significant predictors of reduced total energy intake, reduced energy from protein and fat, and greater energy from carbohydrates. Logistic regression confirmed that inadequate macronutrient intake was more common among the poor, food insecure, and less educated. Conclusions: Imbalanced dietary intakes among underprivileged women reflect lack of dietary diversity. Nutrition programs should be linked with social development, poverty reduction, education programs and behavior change counseling in order to improve the nutritional status of WRA in Vietnam.
British Columbia Legislative Assembly sessional clipping book (1946-04)
Creators: name: :Unav
Publisher: name: University of Victoria Libraries
Year: 2022
Subjects: subject: Politics and government
valueUri: http://id.worldcat.org/fast/1919741
subject: British Columbia. Legislative Assembly
valueUri: http://id.worldcat.org/fast/600765
subject: Law
valueUri: http://id.worldcat.org/fast/993678
subject: FOS: Law

description: These Sessional Clippings books cover the period 1891 to 1972, and include newspaper accounts written by various legislative reporters who covered debates occurring in the British Columbia Legislative Assembly. Transcripts of debates of the Legislative Assembly (Hansard) were not published in B.C. until 1970; hence these "Sessional Clipping Books" augment the "Journals", the record of daily proceedings of the Legislative Assembly. Selected clippings from various newspapers including the Vancouver Sun, the Vancouver Province, the Colonist, and the Times newspapers, relating to the newspaper reports concerning activities of the Legislature. The original sessional clippings books comprise 351 ledger size print volumes, held at the Legislative Library in Victoria BC. The print volumes were microfilmed onto 26 reels in 1977 under a Tri University Libraries (TRIUL) project by Precision Micrographic Services (Vancouver, B.C.), with the permission of the Legislative Library, Victoria, British Columbia. This digital collection was created by scanning the 26 microfilm reels.
Predicting high health-cost users among people with cardiovascular disease using machine learning and nationwide linked social administrative datasets
Creators: name: Nghiem, N
name: Atkinson, J
name: Nguyen, Binh
name: Tran-Duy, A
name: Wilson, N
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2023
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4203
subject: Health services and systems
classificationCode: 3801
subject: Applied economics
classificationCode: 4206
subject: Public health

description: Objectives: To optimise planning of public health services, the impact of high-cost users needs to be considered. However, most of the existing statistical models for costs do not include many clinical and social variables from administrative data that are associated with elevated health care resource use, and are increasingly available. This study aimed to use machine learning approaches and big data to predict high-cost users among people with cardiovascular disease (CVD). Methods: We used nationally representative linked datasets in New Zealand to predict CVD prevalent cases with the most expensive cost belonging to the top quintiles by cost. We compared the performance of four popular machine learning models (L1-regularised logistic regression, classification trees, k-nearest neighbourhood (KNN) and random forest) with the traditional regression models. Results: The machine learning models had far better accuracy in predicting high health-cost users compared with the logistic models. The harmony score F1 (combining sensitivity and positive predictive value) of the machine learning models ranged from 30.6% to 41.2% (compared with 8.6–9.1% for the logistic models). Previous health costs, income, age, chronic health conditions, deprivation, and receiving a social security benefit were among the most important predictors of the CVD high-cost users. Conclusions: This study provides additional evidence that machine learning can be used as a tool together with big data in health economics for identification of new risk factors and prediction of high-cost users with CVD. As such, machine learning may potentially assist with health services planning and preventive measures to improve population health while potentially saving healthcare costs.
Outgassing Behavior of C/2012 S1 (ISON) From September 2011 to June 2013
Creators: name: Meech, Karen J.
name: Yang, Bin
name: Kleyna, Jan
name: Ansdell, Megan
name: Chiang, Hsin-Fang
name: Hainaut, Olivier
name: Vincent, Jean-Baptiste
name: Boehnhardt, Hermann
name: Fitzsimmons, Alan
name: Rector, Travis
name: Riesen, Timm
name: Keane, Jacqueline V.
name: Reipurth, Bo
name: Hsieh, Henry H.
name: Michaud, Peter
name: Milani, Giannantonio
name: Bryssinck, Erik
name: Ligustri, Rolando
name: Trabatti, Roberto
name: Tozzi, Gian-Paolo
name: Mottola, Stefano
name: Kuehrt, Ekkehard
name: Bhatt, Bhuwan
name: Sahu, Devendra
name: Lisse, Carey
name: Denneau, Larry
name: Jedicke, Robert
name: Magnier, Eugene
name: Wainscoat, Richard
Publisher: name: arXiv
Year: 2013
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We report photometric observations for comet C/2012 S1 (ISON) obtained during the time period immediately after discovery (r=6.28 AU) until it moved into solar conjunction in mid-2013 June using the UH2.2m, and Gemini North 8-m telescopes on Mauna Kea, the Lowell 1.8m in Flagstaff, the Calar Alto 1.2m telescope in Spain, the VYSOS-5 telescopes on Mauna Loa Hawaii and data from the CARA network. Additional pre-discovery data from the Pan STARRS1 survey extends the light curve back to 2011 September 30 (r=9.4 AU). The images showed a similar tail morphology due to small micron sized particles throughout 2013. Observations at sub-mm wavelengths using the JCMT on 15 nights between 2013 March 9 (r=4.52 AU) and June 16 (r=3.35 AU) were used to search for CO and HCN rotation lines. No gas was detected, with upper limits for CO ranging between (3.5-4.5)E27 molec/s. Combined with published water production rate estimates we have generated ice sublimation models consistent with the photometric light curve. The inbound light curve is likely controlled by sublimation of CO2. At these distances water is not a strong contributor to the outgassing. We also infer that there was a long slow outburst of activity beginning in late 2011 peaking in mid-2013 January (r~5 AU) at which point the activity decreased again through 2013 June. We suggest that this outburst was driven by CO injecting large water ice grains into the coma. Observations as the comet came out of solar conjunction seem to confirm our models.
description: 8 pages, 2 figures, 3 tables
A Note On Transversals
Creators: name: Jain, Vivek Kumar
Publisher: name: arXiv
Year: 2013
Subjects: subject: Group Theory (math.GR)
subject: FOS: Mathematics
subject: 20D60, 20N05

description: Let $G$ be a finite group and $H$ a core-free subgroup of $G$. We will show that if there exists a solvable, generating transversal of $H$ in $G$, then $G$ is a solvable group. Further, if $S$ is a generating transversal of $H$ in $G$ and $S$ has order 2 invariant sub right loop $T$ such that the quotient $S/T$ is a group. Then $H$ is an elementary abelian 2-group.
description: 7 pages
Exercise improves depression through positive modulation of brain-derived neurotrophic factor (BDNF). A review based on 100 manuscripts over 20 years.
Creators: name: Jemni, Monèm
name: Zaman, Rashid
name: Carrick, Frederick Robert
name: Clarke, Neil David
name: Marina, Michel
name: Bottoms, Lindsay
name: Matharoo, Jagdeep Singh
name: Ramsbottom, Roger
name: Hoffman, Norman
name: Groves, Shad James
name: Gu, Yaodong
name: Konukman, Ferman
Publisher: name: Apollo - University of Cambridge Repository
Year: 2023
Subjects: BDNF expression
depression treatment
exercise mode
neuroplasticity
physical activity intervention

description: Peer reviewed: True
description: Acknowledgements: We would like to thank Mr Liam Pope for his assistance in preparing the manuscript. Also, our thanks to the admin staff at the Carrick Institute for their continuing support.
description: The aim of this review was to explore the relevant neurobiology and the association between peripheral levels of brain-derived neurotrophic factor (BDNF) and acute and short to long-term exercise regimes, as well as its relation to depression and antidepressant treatment. A 20-year literature search was conducted. The screening process resulted in 100 manuscripts. Antidepressants as well as acute exercise, particularly high-intensity, elevates BDNF in healthy humans and clinical populations, as evidenced from aerobic and resistance-based studies. Although exercise is increasingly recognised in the management of depression, acute and short-term exercise studies have failed to establish a relationship between the severity of depression and changes in peripheral BDNF. The latter rapidly returns to baseline, possibly indicating a quick re-uptake by the brain, aiding its neuroplasticity functions. The timescale of administration needed for the antidepressants to stimulate biochemical changes is longer than similar increases with acute exercise.
Additional file 3 of Integrin alpha-2 and beta-1 expression increases through multiple generations of the EDW01 patient-derived xenograft model of breast cancer—insight into their role in epithelial mesenchymal transition in vivo gained from an in vitro model system
Creators: name: Wafai, Razan
name: Williams, Elizabeth D.
name: Souza, Emma De
name: Simpson, Peter T.
name: Reed, Amy E. McCart
name: Kutasovic, Jamie R.
name: Waltham, Mark
name: Snell, Cameron E.
name: Blick, Tony
name: Thompson, Erik W.
name: Hugo, Honor J.
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 3: Supplementary Fig. 3. Image J-based quantification of IHC targets that displayed the greatest visual change between PDXs and across passages 3 to 7 for both PDXs: E-cadherin, Vimentin and Twist1. Relative intensity per cell was calculated by dividing the overall area of DAB positivity for the IHC target by overall nuclear area. Statistical significance was determined by an Ordinary one-way ANOVA, where * indicates p
Using EHRs to integrate research with patient care: promises and challenges
Creators: name: Weng, Chunhua
name: Appelbaum, Paul S.
name: Hripcsak, George M.
name: Kronish, Ian M.
name: Busacca, Linda V.
name: Davidson, Karina W.
name: Bigger, John T.
Publisher: name: Columbia University
Year: 2012
Subjects: subject: Knowledge acquisition (Expert systems)
subject: Clinical medicine--Research
subject: Medical records--Data processing
subject: Medicine
subject: Bioinformatics
subject: FOS: Computer and information sciences
subject: Information technology

description: Clinical research is the foundation for advancing the practice of medicine. However, the lack of seamless integration between clinical research and patient care workflow impedes recruitment efficiency, escalates research costs, and hence threatens the entire clinical research enterprise. Increased use of electronic health records (EHRs) holds promise for facilitating this integration but must surmount regulatory obstacles. Among the unintended consequences of current research oversight are barriers to accessing patient information for prescreening and recruitment, coordinating scheduling of clinical and research visits, and reconciling information about clinical and research drugs. We conclude that the EHR alone cannot overcome barriers in conducting clinical trials and comparative effectiveness research. Patient privacy and human subject protection policies should be clarified at the local level to exploit optimally the full potential of EHRs, while continuing to ensure participant safety. Increased alignment of policies that regulate the clinical and research use of EHRs could help fulfill the vision of more efficiently obtaining clinical research evidence to improve human health.
Conservative and PT-symmetric compactons in waveguide networks
Creators: name: Yulin, A. V.
name: Konotop, V. V.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Optics (physics.optics)
subject: Pattern Formation and Solitons (nlin.PS)
subject: FOS: Physical sciences

description: Stable discrete compactons in arrays of inter-connected three-line waveguide arrays are found in linear and nonlinear limits in conservative and in parity-time PT symmetric models. The compactons result from the interference of the fields in the two lines of waveguides ensuring that the third (middle) line caries no energy. PT-symmetric compactons require not only the presence of gain and losses in the two lines of the waveguides but also complex coupling, i.e. gain and losses in the coupling between the lines carrying the energy and the third line with zero field. The obtained compactons can be stable and their branches can cross the branches of the dissipative solitons. Unusual bifurcations of branches of solitons from linear compactons are described.
description: Accepted for Optics Letters
No association of a Vascular endothelial growth factor A (VEGFA) gene polymorphism with pre-eclampsia among pregnant women in Uganda.
Creators: name: Nabweyambo, Sheila
name: Kanyerezi, Stephen
name: Petterson, John H-O
name: Katabazi, Fred Ashaba
name: Ssekagiri, Alfred
name: Mwesigwa, Savannah
name: Mboowa, Gerald
name: Nakazzi, Faith
name: Keesiga, Annette
name: Adroma, Moses
name: Bwanga, Freddie
name: McGovern, Naomi
name: Sande, Obondo James
name: Nakimuli, Annettee
Publisher: name: Apollo - University of Cambridge Repository
Year: 2023
Subjects: 3’ Untranslated region
Africa
Genetic biomarkers
Genetic variations
Pre-eclampsia
Sanger sequencing
Single nucleotide polymorphism
Uganda
Vascular endothelial growth factor
Humans
Female
Pregnancy
Pre-Eclampsia
Pregnant Women
Vascular Endothelial Growth Factor A
3' Untranslated Regions
Genotype
Polymorphism, Single Nucleotide
Case-Control Studies
Genetic Predisposition to Disease

description: Acknowledgements: We acknowledge the support given by Edgar Kigozi on behalf of the Medical and Molecular Laboratory, College of Health Sciences, Makerere University, Kampala, Uganda, towards administration of study laboratory events, optimisation and performing of laboratory assays, and shipping of generated PCR products to sequencing company. We recognise the support provided by the study team, including; Maxine Atuheirwe, Rosemary Byenkya, Margaret Sewagaba, Elizabeth Mutesi, Ruth Namubiru, Emily Nakirijja, Moreen Ahimbisibwe, Florence Walabyeki, Noela Kalyowa, Rita Kukundakwe, and Doreen Birungi.
description: BACKGROUND: Vascular endothelial growth factor A (VEGFA) is a major angiogenic factor that plays an important role in the formation of blood vessels during embryonic development. VEGFA has been implicated in the pathophysiology of pre-eclampsia (PE), since pre-eclamptic women present with reduced levels of free circulating VEGFA. The 3' untranslated region (3'-UTR) of the VEGFA gene consists of elements that regulate the transcription and hence expression of the VEGFA protein in circulation. Hence it is suggested that variations thereof could underlie the reduced VEGFA levels observed in pre-eclamptic women. The purpose of this study was to investigate presence of the + 936C/T polymorphism, a common single nucleotide polymorphism (SNP) in the 3'-UTR of the VEGFA gene, and determine its association with PE among pregnant women in Uganda. RESULTS: There was no significant difference observed in the allele and genotype frequencies of the + 936C/T 3' UTR-VEGFA polymorphism between pre-eclamptic and normotensive pregnant women (P > 0.05). Additionally, there was no significant difference in the median plasma levels of free VEGFA among women with the wild type, CT and TT genotypes of the + 936C/T VEGFA polymorphism (median = 0.84 pg/mL (IQR = 0.39-1.41) Vs 1.05 (0.61-1.18) Vs 1.05 (1.05-1.05) respectively, p-value = 0.7161). CONCLUSIONS: These study findings indicate that the + 936C/T 3' UTR-VEGFA polymorphism had no significant association with increased susceptibility to PE among women in Uganda. Further studies with a larger sample size are recommended.
Second-Order Algebraic Theories
Creators: name: Fiore, Marcelo
name: Mahmoud, Ola
Publisher: name: arXiv
Year: 2013
Subjects: subject: Logic in Computer Science (cs.LO)
subject: Category Theory (math.CT)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: Fiore and Hur recently introduced a conservative extension of universal algebra and equational logic from first to second order. Second-order universal algebra and second-order equational logic respectively provide a model theory and a formal deductive system for languages with variable binding and parameterised metavariables. This work completes the foundations of the subject from the viewpoint of categorical algebra. Specifically, the paper introduces the notion of second-order algebraic theory and develops its basic theory. Two categorical equivalences are established: at the syntactic level, that of second-order equational presentations and second-order algebraic theories; at the semantic level, that of second-order algebras and second-order functorial models. Our development includes a mathematical definition of syntactic translation between second-order equational presentations. This gives the first formalisation of notions such as encodings and transforms in the context of languages with variable binding.
Clustering Algorithm for Gujarati Language
Creators: name: Patel, Miral
name: Balani, Prem
Publisher: name: arXiv
Year: 2013
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences

description: Natural language processing area is still under research. But now a day it is on platform for worldwide researchers. Natural language processing includes analyzing the language based on its structure and then tagging of each word appropriately with its grammar base. Here we have 50,000 tagged words set and we try to cluster those Gujarati words based on proposed algorithm, we have defined our own algorithm for processing. Many clustering techniques are available Ex. Single linkage, complete, linkage,average linkage, Hear no of clusters to be formed are not known, so it is all depends on the type of data set provided . Clustering is preprocess for stemming . Stemming is the process where root is extracted from its word. Ex. cats= cat+S, meaning. Cat: Noun and plural form.
Additional file 5 of Integrin alpha-2 and beta-1 expression increases through multiple generations of the EDW01 patient-derived xenograft model of breast cancer—insight into their role in epithelial mesenchymal transition in vivo gained from an in vitro model system
Creators: name: Wafai, Razan
name: Williams, Elizabeth D.
name: Souza, Emma De
name: Simpson, Peter T.
name: Reed, Amy E. McCart
name: Kutasovic, Jamie R.
name: Waltham, Mark
name: Snell, Cameron E.
name: Blick, Tony
name: Thompson, Erik W.
name: Hugo, Honor J.
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 5: Supplementary Fig. 5. Image J-based quantification of relative intensity per cell of IHC targets that displayed the greatest visual change between PDXs and across passages 3 to 7 for both PDXs: CD24 and CD44. Relative intensity per cell was calculated by dividing the overall area of DAB positivity for the IHC target by overall nuclear area. Statistical significance was determined by an Ordinary one-way ANOVA, where * indicates p
Magnetic orders of LaTiO$_3$ under epitaxial strain: a first-principles study
Creators: name: Weng, Yakui
name: Huang, Xin
name: Tang, Yankun
name: Dong, Shuai
Publisher: name: arXiv
Year: 2013
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Perovskite LaTiO$_3$ bulk is a typical Mott-insulator with G-type antiferromagnetic order. In this work, the biaxial strain effects on the ground magnetic order of LaTiO$_3$ films grown on various substrates have been studied. For the compressive strain, LaTiO$_3$ films grown on LaAlO$_3$, LaGaO$_3$, and SrTiO$_3$ substrates undergo a phase transition from the original G-type antiferromagnet to A-type antiferromagnet. The underlying physical mechanisms are the lattice distortions tunned by strain. While for the tensile strain, the BaTiO$_3$ and LaScO$_3$ substrates have been tested, which show a tendency to transit the LaTiO$_3$ to the C-type antiferromagnet. Furthermore, our calculations find that the magnetic transitions under epitaxial strain do not change the insulating fact of LaTiO$_3$.
description: 3 pages, 3 figures. Proceeding of the 58th MMM conference, accepted
The risk of childhood autism among second-generation migrants in Finland: a case–control study
Creators: name: Lehti, Venla
name: Hinkka-Yli-Salomäki, Susanna
name: Cheslack-Postava, Keely
name: Gissler, Mika
name: Brown, Alan S.
name: Sourander, Andre
Publisher: name: Columbia University
Year: 2013
Subjects: Immigrants
Autism in children
Psychiatry
Epidemiology

description: Background: Studying second-generation immigrants can help in identifying genetic or environmental risk factors for childhood autism. Most previous studies have focused on maternal region of birth and showed inconsistent results. No previous study has been conducted in Finland. Methods: The study was a nested case–control study based on a national birth cohort. Children born in 1987–2005 and diagnosed with childhood autism by the year 2007 were identified from the Finnish Hospital Discharge Register. Controls were selected from the Finnish Medical Birth Register. Information on maternal and paternal country of birth and mother tongue was collected from the Finnish Central Population Register. There were 1132 cases and 4515 matched controls. The statistical test used was conditional logistic regression analysis. Results: Compared with children with two Finnish parents, the risk of childhood autism was increased for those whose parents are both immigrants (adjusted odds ratio [aOR] 1.8, 95% confidence interval [CI] 1.2–2.7) and for those with only an immigrant mother (aOR 1.8, 95% CI 1.2–2.7), but not for those with only an immigrant father. The risk was increased for those with a mother born in the former Soviet Union or Yugoslavia and for those with a mother or a father born in Asia. Specific parental countries of birth associated with an increased risk were the former Soviet Union, the former Yugoslavia and Vietnam. Conclusions: In Finland, children who are born to immigrant mothers with or without an immigrant partner, have an increased risk of childhood autism. The risk varies with immigrant parents’ region of birth. The findings may help in identifying possible risk factors, which can be examined in future studies.
Personalized statistical modeling of soft tissue structures in the knee.
Creators: name: Van Oevelen, A
name: Duquesne, K
name: Peiffer, M
name: Grammens, J
name: Burssens, A
name: Chevalier, A
name: Steenackers, G
name: Victor, J
name: Audenaert, E
Publisher: name: Apollo - University of Cambridge Repository
Year: 2023
Subjects: computational modeling
knee joint
personalized medicine
soft-tissue modeling
statistical shape modeling

description: Peer reviewed: True
description: Background and Objective: As in vivo measurements of knee joint contact forces remain challenging, computational musculoskeletal modeling has been popularized as an encouraging solution for non-invasive estimation of joint mechanical loading. Computational musculoskeletal modeling typically relies on laborious manual segmentation as it requires reliable osseous and soft tissue geometry. To improve on feasibility and accuracy of patient-specific geometry predictions, a generic computational approach that can easily be scaled, morphed and fitted to patient-specific knee joint anatomy is presented. Methods: A personalized prediction algorithm was established to derive soft tissue geometry of the knee, originating solely from skeletal anatomy. Based on a MRI dataset (n = 53), manual identification of soft-tissue anatomy and landmarks served as input for our model by use of geometric morphometrics. Topographic distance maps were generated for cartilage thickness predictions. Meniscal modeling relied on wrapping a triangular geometry with varying height and width from the anterior to the posterior root. Elastic mesh wrapping was applied for ligamentous and patellar tendon path modeling. Leave-one-out validation experiments were conducted for accuracy assessment. Results: The Root Mean Square Error (RMSE) for the cartilage layers of the medial tibial plateau, the lateral tibial plateau, the femur and the patella equaled respectively 0.32 mm (range 0.14-0.48), 0.35 mm (range 0.16-0.53), 0.39 mm (range 0.15-0.80) and 0.75 mm (range 0.16-1.11). Similarly, the RMSE equaled respectively 1.16 mm (range 0.99-1.59), 0.91 mm (0.75-1.33), 2.93 mm (range 1.85-4.66) and 2.04 mm (1.88-3.29), calculated over the course of the anterior cruciate ligament, posterior cruciate ligament, the medial and the lateral meniscus. Conclusion: A methodological workflow is presented for patient-specific, morphological knee joint modeling that avoids laborious segmentation. By allowing to accurately predict personalized geometry this method has the potential for generating large (virtual) sample sizes applicable for biomechanical research and improving personalized, computer-assisted medicine.
title: Being in labour – Gebären als Arbeit im gegenwärtigen Kapitalismus
Creators: name: Reich, Marie
name: Kuhnt, Anne-Kristin
Publisher: name: Humboldt-Universität zu Berlin
Year: 2024
Subjects: subject: Care
subject: Geburt
subject: Geburtsarbeit
subject: Gegenwartskapitalismus
subject: Leihmutterschaft
subject: Reproduktionsarbeit
subject: ddc:303

description: Dieser Beitrag wendet einen marxistisch-feministischen Arbeitsbegriff auf die Tätigkeit des Gebärens an. Ziel ist es, aus einer gesellschaftstheoretischen Perspektive neue Erkenntnisse über die Organisation und die Praktiken des Gebärens in Gegenwartsgesellschaften zu generieren. Diese Perspektive führt zu drei zentralen Ergebnissen: (1) Sich verschlechternde Bedingungen für Gebärende, Hebammen und Gynäkolog*innen sowie sich verändernde Geburtspraktiken werden erklärbar, wenn Gebären als Teil der abgewerteten Reproduktionsarbeit im Kapitalismus identifiziert wird. (2) Über den Arbeitsbegriff können bezahlte und unbezahlte Geburten in ihren Wechselwirkungen untersucht werden. (3) Eine marxistischfeministische Perspektive auf Geburten macht widerständige Momente sichtbar und kann so einen Beitrag zu einer emanzipatorischen Gesellschaftstheorie leisten. Wir schlussfolgern, dass sich der Arbeitsbegriff aus marxistischfeministischer Perspektive adäquat auf das Gebären anwenden lässt und dadurch zum einen neue gesellschaftstheoretische Erkenntnisse sichtbar werden, zum anderen das Verständnis von Prozessen rund um die Geburt vertieft wird.
Experimental Comparison of Efficient Tomography Schemes for a Six-Qubit State
Creators: name: Schwemmer, Christian
name: Toth, Geza
name: Niggebaum, Alexander
name: Moroder, Tobias
name: Gross, David
name: Gühne, Otfried
name: Weinfurter, Harald
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum state tomography suffers from the measurement effort increasing exponentially with the number of qubits. Here, we demonstrate permutationally invariant tomography for which, contrary to conventional tomography, all resources scale polynomially with the number of qubits both in terms of the measurement effort as well as the computational power needed to process and store the recorded data. We demonstrate the benefits of combining permutationally invariant tomography with compressed sensing by studying the influence of the pump power on the noise present in a six-qubit symmetric Dicke state, a case where full tomography is possible only for very high pump powers.
description: 7 pages, 7 figures
Additional file 7 of Integrin alpha-2 and beta-1 expression increases through multiple generations of the EDW01 patient-derived xenograft model of breast cancer—insight into their role in epithelial mesenchymal transition in vivo gained from an in vitro model system
Creators: name: Wafai, Razan
name: Williams, Elizabeth D.
name: Souza, Emma De
name: Simpson, Peter T.
name: Reed, Amy E. McCart
name: Kutasovic, Jamie R.
name: Waltham, Mark
name: Snell, Cameron E.
name: Blick, Tony
name: Thompson, Erik W.
name: Hugo, Honor J.
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 7: Supplementary Fig. 7. Assessment of clinical parameters (Regression Free Survival-RFS, Overall Survival-OS, Distant Metastasis Free Survival-DMFS and Progression Free Survival-PFS) in Luminal A cancers with respect to high versus low ITGB1, ITGA2 or ILK expression, as derived from a previously published database [65].
Progression of coronary artery atherosclerosis in rheumatoid arthritis: comparison with participants from the Multi-Ethnic Study of Atherosclerosis
Creators: name: Chung, Cecilia
name: Giles, Jon T.
name: Kronmal, Richard
name: Post, Wendy
name: Gelber, Allan
name: Petri, Michelle
name: Szklo, Moyses
name: Detrano, Robert
name: Budoff, Matthew
name: Blumenthal, Roger
name: Ouyang, Pamela
name: Bush, David
name: Bathon, Joan M.
Publisher: name: Columbia University
Year: 2013
Subjects: Coronary arteries--Calcification
Rheumatoid arthritis
Medicine
Medical sciences

description: Introduction: In cross-sectional studies, patients with rheumatoid arthritis (RA) have higher coronary artery calcium (CAC) than controls. However, their rate of progression of CAC and the predictors of CAC progression have heretofore remained unknown. Methods: Incidence and progression of CAC were compared in 155 patients with RA and 835 control participants. The association of demographic characteristics, traditional cardiovascular risk factors, RA disease characteristics and selected inflammatory markers with incidence and progression of CAC were evaluated. Results: The incidence rate of newly detected CAC was 8.2/100 person-years in RA and 7.3/100 person-years in non-RA control subjects [IRR 1.1 (0.7-1.8)]. RA patients who developed newly detectable CAC were older (59±7 vs. 55±6 years old, p=0.03), had higher triglyceride levels (137±86 vs. 97±60 mg/dL, p=0.03), and higher systolic blood pressure (129±17 vs. 117±15 mm Hg, p=0.01) compared to those who did not develop incident CAC. Differences in blood pressure and triglyceride levels remained significant after adjustment for age (p<=0.05). RA patients with any CAC at baseline had a median rate of yearly progression of 21 (7–62) compared to 21 (5–70) Agatston units in controls. No statistical differences between RA progressors and RA non-progressors were observed for inflammatory markers or for RA disease characteristics. Conclusions: The incidence and progression of CAC did not differ between RA and non-RA participants. In patients with RA, incident CAC was associated with older age, higher triglyceride levels, and higher blood pressure, but not with inflammatory markers or RA disease characteristics.
Reduced cerebral blood flow and white matter hyperintensities predict poor sleep in heart failure
Creators: name: Alosco, Michael
name: Brickman, Adam M.
name: Spitznagel, Mary
name: Griffith, Erica
name: Narkhede, Atul
name: Cohen, Ronald
name: Sweet, Lawrence
name: Hughes, Joel
name: Rosneck, Jim
name: Gunstad, John
Publisher: name: Columbia University
Year: 2013
Subjects: subject: Heart failure
subject: Sleep disorders
subject: Neurosciences
subject: FOS: Clinical medicine

description: Background: Poor sleep is common in heart failure (HF), though mechanisms of sleep difficulties are not well understood. Adverse brain changes among regions important for sleep have been demonstrated in patients with HF. Cerebral hypoperfusion, a correlate of sleep quality, is also prevalent in HF and a likely contributor to white matter hyperintensities (WMH). However, no study to date has examined the effects of cerebral blood flow, WMH, and brain volume on sleep quality in HF. Methods: Fifty-three HF patients completed the Pittsburgh Sleep Quality Index and underwent brain magnetic resonance imaging to quantify brain and WMH volume. Transcranial Doppler ultrasonography assessed cerebral blood flow velocity of the middle cerebral artery (CBF-V of the MCA). Results: 75.5% of HF patients reported impaired sleep. Regression analyses adjusting for medical and demographic factors showed decreased CBF-V of the MCA and greater WMH volume were associated with poor sleep quality. No such pattern emerged on total brain or regional volume indices. Conclusions: Decreased cerebral perfusion and greater WMH may contribute to sleep difficulties in HF. Future studies are needed to confirm these findings and clarify the effects of cerebral blood flow and WMH on sleep in healthy and patient samples.
Camilo Castelo Branco O Demónio do Ouro. 6.ª edição. Parceria A. M. Pereira. 2 vols. de 258 e 228 ps. 130x195. Lisboa 1970
Creators: name: Bragança, António Joaquim
Publisher: name: Theologica
Year: 1970

description: Theologica, v. 5 n. 4 (1970)
The effects of radiation on angiogenesis
Creators: name: Grabham, Peter W.
name: Sharma, Preety
Publisher: name: Columbia University
Year: 2013
Subjects: Ionizing radiation
Cancer--Radiotherapy
Cytology
Medical sciences

description: The average human body contains tens of thousands of miles of vessels that permeate every tissue down to the microscopic level. This makes the human vasculature a prime target for an agent like radiation that originates from a source and passes through the body. Exposure to radiation released during nuclear accidents and explosions, or during cancer radiotherapy, is well known to cause vascular pathologies because of the ionizing effects of electromagnetic radiations (photons) such as gamma rays. There is however, another type of less well-known radiation – charged ion particles, and these atoms stripped of electrons, have different physical properties to the
photons of electromagnetic radiation. They are either found in space or created on earth by particle collider facilities, and are of significant recent interest due to their enhanced effectiveness and increasing use in cancer
radiotherapy, as well as a health risk to the growing number of people spending time in the space environment. Although there is to date, relatively few studies on the effects of charged particles on the vascular system, a very
different picture of the biological effects of these particles compared to photons is beginning to emerge. These under researched biological effects of ion particles have a large impact on the health consequences of exposure. In this short review, we will discuss the effects of charged particles on an important biological process of the vascular system, angiogenesis, which creates and maintains the vasculature and is highly important in tumor vasculogenesis.
Camilo Castelo Branco, Quatro horas inocentes. Ed. Parceria A. M. Pereira Lda. Vol. de 196 ps. 130x195. Lisboa 1968
Creators: name: Bragança, António Joaquim
Publisher: name: Theologica
Year: 1970

description: Theologica, v. 5 n. 4 (1970)
Mimetic Dark Matter
Creators: name: Chamseddine, Ali H.
name: Mukhanov, Viatcheslav
Publisher: name: arXiv
Year: 2013
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We reformulate Einstein's theory of gravity, isolating the conformal degree of freedom in a covariant way. This is done by introducing a physical metric defined in terms of an auxiliary metric and a scalar field appearing through its first derivatives. The resulting equations of motion split into a traceless equation obtained through variation with respect to the auxiliary metric and an additional differential equation for the trace part. As a result the conformal degree of freedom becomes dynamical even in the absence of matter. We show that this extra degree of freedom can mimic cold dark matter.
description: 5 pages
Bathyergus Illiger 1811
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Bathyergidae
Bathyergus

description: Bathyergus Illiger, 1811. Prodr. Syst. Mamm. et Avium., p. 86. ISIS NUMBER: 5301410032001000000.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Rodentia (Part 6), pp. 560-594 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 592, DOI: 10.5281/zenodo.7353039
Camilo Castelo Branco, Esboços de Apreciações Literárias. Ed. Parceria A. M. Pereira Lda. Vol. de 312 ps. 130x195. Lisboa 1969
Creators: name: Bragança, António Joaquim
Publisher: name: Theologica
Year: 1970

description: Theologica, v. 5 n. 4 (1970)