cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1: Table S1. of Dual leucine zipper kinase regulates expression of axon guidance genes in mouse neuronal cells
Creators: name: Blondeau, Andréanne
name: Jean-François Lucier
name: Matteau, Dominick
name: Lauralyne Dumont
name: Rodrigue, Sébastien
name: Pierre-Étienne Jacques
name: Blouin, Richard
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Primers used in this study. (PDF 60 kb)
Tromikosoma koehleri Mortensen 1903
Creators: name: Madeira, Patrícia
name: Kroh, Andreas
name: Cordeiro, Ricardo
name: De, António M.
name: Martins, Frias
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Echinoidea
Echinothurioida
Echinothuriidae
Tromikosoma
Tromikosoma koehleri

description: Tromikosoma koehleri Mortensen, 1903
Reports for the Azores:
Tromikosoma cf. koehleri Mortensen, 1903 — $ Mironov 2008: 4, tab. 1;
Tromikosoma koehleri Mortensen, 1903 — Mironov 2014: 122.
Type locality: Davis Strait.
See: Mortensen (1935: 167–168, fig. 100, pl. 5).
Occurrence: North Atlantic, from the Davis Strait (Mortensen 1903) south to the Charlie-Gibbs Fracture Zone and north of the Azores (Mironov 2008).
Depth: 2,517–3,527 m (AZO: 2,954–2,968 m; Mironov 2008).
Habitat: probably a bottom-feeder living on soft sediments.
Remarks: Tromikosoma koehleri was only known from its type locality. More recently, Mironov (2008) reported this species among the material collected by G.O. Sars (MAR–ECO expedition) in the Charles-Gibbs Fracture Zone. The same author listed material likely to belong to this rare species collected at stations located in the northern waters of the Azores (G.O. Sars, MAR–ECO cruise, sta 40/367: 42°55”N, 30°20”W, 2,954 –2,968 m). Later, however, Mironov (2014) placed the MAR-ECO ’ station from the Azores in the geographical distribution of this species. Mironov also added that this species is very closely related to T. uranus also known from the Atlantic (see below). Both species are known from very little material, and may prove to be identical.
description: Published as part of Madeira, Patrícia, Kroh, Andreas, Cordeiro, Ricardo, De, António M., Martins, Frias & Ávila, Sérgio P., 2019, The Echinoderm Fauna of the Azores (NE Atlantic Ocean), pp. 1-231 in Zootaxa 4639 (1) on page 121, DOI: 10.11646/zootaxa.4639.1, http://zenodo.org/record/3342161
Development of embryonic stem cells expressing endogenous levels of a fluorescent protein fused to the telomere binding protein TRF1
Creators: name: Miller, Shelley Bonnie
Publisher: name: University of British Columbia
Year: 2008

description: Telomeres are the repetitive DNA sequence and associated proteins found at the ends of linear chromosomes. They have a role in biological processes including meiosis and aging as well as implications in a number of genomic instability disorders and cancers. Telomeres maintain genomic stability by protecting chromosome ends from terminal fusions and misidentification as DNA damage sites. Their wide range of functions has resulted in an increased interest in developing tools to study the dynamics of telomeres in live cells. To do this, current studies use the ubiquitously expressed protein Telomere Repeat Factor 1 (TRF1) tagged with a fluorescent protein. TRF1 is a negative regulator of telomere length that binds exclusively to telomere repeats. Over-expression of the fluorescent protein fused to TRF1 has been a useful tool to track telomere movement. The foci formed by the tagged TRF1 protein accurately represent the number of telomeres expected in the cells and the localization is maintained throughout the cell cycle. A caveat with this system is that over-expression of TRF1 leads to accelerated telomere shortening, as well as replication defects that can stall telomere replication. These caveats make it difficult to draw conclusions about telomere dynamics based solely on observations of cells over-expressing fluorescently tagged TRF1. To eliminate problems associated with protein over-expression, I have tried to develop knock-in embryonic stem (ES) cells expressing fluorescently tagged TRF1 from the endogenous Trf1 promoter. To do this, I have used a recombineering technique using Bacterial Artificial Chromosomes (BACs). BAC recombineering allows for the direct knock-in of a fluorescent tag into the mouse Trf1gene locus. Genetic constructs with the correct sequence inserts have been obtained and have been used for transfection of ES cells. While no correctly targeted ES cells have been identified so far, the expectation is that ES cell lines with correctly targeted fluorescently tagged TRF1 will be obtained in the near future. Such lines will be used to study telomere dynamics in ES cells, differentiated cells generated from ES cells, as well as to generate mice.
MOESM2 of High-fat diet-induced obesity exacerbates kainic acid-induced hippocampal cell death
Creators: name: Kang, Dong
name: Heo, Rok
name: Chin-Ok Yi
name: Hwajin Kim
name: Choi, Chang
name: Roh, Gu
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Cancer
subject: 60506 Virology
subject: Computational Biology

description: Additional file 2: Table S1. Effects of a HFD on serum metabolic parameters.
Tromikosoma uranus ? (Thomson 1877
Creators: name: Madeira, Patrícia
name: Kroh, Andreas
name: Cordeiro, Ricardo
name: De, António M.
name: Martins, Frias
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Echinoidea
Echinothurioida
Echinothuriidae
Tromikosoma
Tromikosoma uranus

description: Tromikosoma uranus? (Thomson, 1877)
Reports for the Azores:
Phormosoma uranus Thomson, 1877 —? $ Agassiz 1881: 103–104, pl. 18c, fig. 12;
non Phormosoma uranus Thomson, 1877 — Koehler 1898: 7, 10–15, pl. 1, fig. 1, pl. 3, figs. 5–6, pl. 9, figs. 49, 50. [misidentified H. petersii];
Echinosoma uranus Thomson, 1877 —? $ H.L. Clark 1925: 57.
Type locality: Gorringe Ridge, off Portugal (36°23’N, 11°18’W).
See: Mortensen (1935: 168–170, pl. 6, figs. 2– 3, pl. 75, figs. 19–21).
Occurrence: Northeast Atlantic, from off Portugal (Thomson 1877) to off the Western Sahara coast (Mortensen 1927b) and the?Azores (H.L. Clark 1925).
Depth: 938– 2,745 m (Mortensen 1935);? AZO: 1,830 m (H.L. Clark 1925).
Habitat: most probably a bottom-feeder on soft sediments.
Remarks: Tromikosoma uranus was recorded from the Azores based on specimens collected by the H.M.S. Challenger (Agassiz 1881), Hirondelle and Talisman (Koehler 1898). Except for H.M.S. Challenger material, all other were re-examined and re-assigned to H. petersii (Mortensen 1903; Koehler 1909; Mortensen 1935). The specimen from H.M.S. Challenger was a young specimen (7 mm) in a poor state of preservation, which rendered the identification impossible (see Mortensen 1903). The occurrence of this species in the area should be considered with caution, until new material is retrieved from the Azores (see remarks under T. koehleri).
description: Published as part of Madeira, Patrícia, Kroh, Andreas, Cordeiro, Ricardo, De, António M., Martins, Frias & Ávila, Sérgio P., 2019, The Echinoderm Fauna of the Azores (NE Atlantic Ocean), pp. 1-231 in Zootaxa 4639 (1) on page 121, DOI: 10.11646/zootaxa.4639.1, http://zenodo.org/record/3342161
Phormosoma placenta subsp. placenta placenta Thomson 1872
Creators: name: Madeira, Patrícia
name: Kroh, Andreas
name: Cordeiro, Ricardo
name: De, António M.
name: Martins, Frias
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Echinoidea
Echinothurioida
Phormosomatidae
Phormosoma
Phormosoma placenta
Phormosoma placenta placenta thomson, 1872b

description: Phormosoma placenta placenta Thomson, 1872b
Reports for the Azores:
Phormosoma placenta Thomson, 1872 b— $ Mortensen 1927b: 25; Mortensen 1935: 125–135, figs. 80–82, pl. 1, figs. 1–5, pl. 2, figs. 1–19, pl. 74, figs. 1–6, 19; Marques 1980: 105; Benavides-Serrato et al. 2012: 53.
Type locality: about 100 miles to the north of the Butt of the Lewis, in Scottish waters (59°43’N, 7°40’W).
See: Thomson (1872b: 732–737, pl. 62, figs. 1–5, pl. 63, figs. 1–9, 9a); Mortensen (1935).
Occurrence: North Atlantic, in the Davis Strait (Mortensen 1903) south to the Northeast coast of USA (Koehler 1921a, H.L. Clark 1925) eastwards south of Iceland (Mortensen 1903) to Gulf of Guinea (Koehler 1909, Grieg 1932, Chesher 1966), including the Azores, Canary and Cape Verde archipelagos (Koehler 1909, Mortensen 1927b). The subspecies P. placenta sigsbey Agassiz, 1880 and P. placenta africana Mortensen, 1934 are reported from the Caribbean and South African waters, respectively (Mortensen 1935, Serafy & Fell 1985).
Depth: 215– 2,500 m (Mortensen 1935); AZO: 1,257 m (Mortensen 1927b).
Habitat: gregarious bottom-feeder (Serafy & Fell 1985) on soft sediments (muddy sand to soft ooze; Gage et al. 1985).
Larval stage: lecithotrophic (Emlet 1995).
Remarks: the record of Phormosoma placenta in the Azores is based on Mortensen (1927b) who identified this species among the material collected by Talisman (sta 127, 1883: 38°38’00”N, 28°20’46”W, 1,257 m).
description: Published as part of Madeira, Patrícia, Kroh, Andreas, Cordeiro, Ricardo, De, António M., Martins, Frias & Ávila, Sérgio P., 2019, The Echinoderm Fauna of the Azores (NE Atlantic Ocean), pp. 1-231 in Zootaxa 4639 (1) on pages 122-123, DOI: 10.11646/zootaxa.4639.1, http://zenodo.org/record/3342161
Antocha (Antocha) quadrifurca Alexander 1971
Creators: name: Markevičiūtė, Radvilė
name: Podenas, Sigitas
name: Saldaitis, Aidas
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Limoniidae
Antocha
Antocha quadrifurca

description: Antocha (Antocha) quadrifurca Alexander, 1971
(Figs 14, 29–35)
Antocha (Antocha) quadrifurca Alexander, 1971: 170–171 (description), 168 (illustration).
Diagnosis. Dark brownish-grey species; antenna black, flagellar segments oblong, oval (Fig. 29); wing subhyaline, milky, pterostigma pale brown (Fig. 30); tergite 9 narrowly transverse without lobes (Figs 14, 33); sternite 9 large, posterior border strongly convex (Fig. 32); gonocoxite oblong, rounded (Figs 14, 31, 34, 35); outer gonostylus short, stout, apex obliquely truncate (Fig. 31); interbase oblong, rounded at apex (Figs 14, 31); paramere forked at apex (Figs 34, 35); apex of aedeagus flattened into lyrate plate with two small bumps (Figs 14, 31, 34, 35); lateral structures branched, connected at apex of aedeagus, inner branch approximately three times longer than outer branch (Figs 14, 31, 35).
Material examined. 1 ♂ (in ethanol): CHINA, W. Sichuan, road Yaan / Kangding Erlang Shan Mt., H- 2161 m, N29.87340, E102.30970, 2017.IX.11–12, leg. A. Saldaitis (NRC).
Elevation range in China. Specimens were collected at 2161 m altitude.
Habitat. Small streams surrounded by mountainous mixed forest.
Distribution. The species was known previously only in India (Assam), and is herein newly recorded from China (Sichuan).
description: Published as part of Markevičiūtė, Radvilė, Podenas, Sigitas & Saldaitis, Aidas, 2021, New Antocha Osten Sacken (Diptera: Limoniidae) from Sichuan, China, pp. 280-292 in Zootaxa 4969 (2) on page 288, DOI: 10.11646/zootaxa.4969.2.3, http://zenodo.org/record/4749005
Brissopsis lyrifera subsp. lyrifera lyrifera (Forbes 1841
Creators: name: Madeira, Patrícia
name: Kroh, Andreas
name: Cordeiro, Ricardo
name: De, António M.
name: Martins, Frias
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Echinoidea
Spatangoida
Brissidae
Brissopsis
Brissopsis lyrifera
Brissopsis lyrifera lyrifera (forbes, 1841)

description: Brissopsis lyrifera lyrifera (Forbes, 1841)
Reports for the Azores:
Brissopsis lyrifera (Forbes, 1841) — $ Koehler 1895a: 225, 1898: 7, 24, 73; Grieg 1932: 43; Nobre 1938: 132–133, fig. 57; Pereira 1997: 335; Micael & Costa 2010: 323; Micael et al. 2012: 4; García-Diez et al. 2005: 51.
Type locality: Scotland, British Isles.
See: Forbes (1841: 187–189); Mortensen (1951b: 380–390, pl. 30, figs. 1–4, 7–13, pl. 32, figs. 15, 20, 22, pl. 57, fig. 15); Chesher (1968: 90–96, figs. 8, 18–19; pl. 21, figs. a–b, as Brissopsis lyrifera capensis).
Occurrence: Mediterranean Sea and east Atlantic, from Iceland and Scandinavia (Mortensen 1907) to NW Africa (Mortensen 1927a, b, Grieg 1932), including the Azores (Koehler 1898); the subspecies B. lyrifera capensis Mortensen 1907 was reported from South Africa, the Gulf of Guinea and the Caribbean (Chesher 1966, 1968).
Depth: 5– 2,250 m (Mortensen 1951 b, Mecho et al. 2014); AZO: 130 m (Koehler 1898).
Habitat: buried in sand, mud to detritic substrates (Mortensen 1927a, Cherbonnier 1969).
Larval stage: planktotrophic (Harvey et al. 1988).
Remarks: the only known material of Brissopsis lyrifera from the Azores is restricted to a single small specimen identified by Koehler (1895a, 1898) among the material collected by Hirondelle (sta 226: 38°31’19”N, 28°34’31”W) in the channel between Pico and Faial islands, at a depth of 130 m.
description: Published as part of Madeira, Patrícia, Kroh, Andreas, Cordeiro, Ricardo, De, António M., Martins, Frias & Ávila, Sérgio P., 2019, The Echinoderm Fauna of the Azores (NE Atlantic Ocean), pp. 1-231 in Zootaxa 4639 (1) on page 123, DOI: 10.11646/zootaxa.4639.1, http://zenodo.org/record/3342161
Palaeotropus josephinae Loven 1871
Creators: name: Madeira, Patrícia
name: Kroh, Andreas
name: Cordeiro, Ricardo
name: De, António M.
name: Martins, Frias
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Echinoidea
Spatangoida
Palaeotropidae
Palaeotropus
Palaeotropus josephinae

description: Palaeotropus josephinae Lovén, 1871
Reports for the Azores:
Palaeotropus josephinae $ Lovén, 1874: 17–18, pl. 12, fig. 105, pl. 13, figs. 108–113, pl. 32, fig. 200; Agassiz 1881: 218; H.L. Clark 1917: 152–153; Mortensen 1927a: 322, 1950: 294–298, figs. 205, 206a, 207b, pl. 25, figs. 14, 19, 21–22, 30–33; García-Diez et al. 2005: 51; Mironov 2006: 115–117, figs. 6–7;
Palaeotropus Hirondellei $ Koehler, 1895a: 226–227, 1895b: 230–231, 1898: 29–30, pl. 5, figs. 12–14, pl. 6, figs. 26–27, pl. 9, fig. 47, 1909: 244–245, pl. 30, figs. 18–23, pl. 31, figs. 4–5, 1921a: 3.
Type locality: Azores (Vila Franca, S„o Miguel).
See: Lovén (1874); Mortensen (1950); Mironov (2006).
Occurrence: East Atlantic, known from the Bay of Biscay, the Azores Archipelago (Koehler 1909), Hyeres and tropic NE Atlantic seamounts (Mironov 2006); also reported from a seamount located north of St. Helena (11°37’S, 5°12’W; Mironov 2006).
Depth: 300– 1,600 m (AZO: 500– 1,600 m; Koehler 1909, Mironov 2006).
Habitat: soft to hard bottoms (mud, sand, gravel and rock; Koehler 1898, 1909).
Larval stage: planktotrophic (Mortensen 1950).
Remarks: Lovén (1871, 1874) described the deep-water species Palaeotropus josephinae based on material collected by Josephine expedition near Vila Franca do Campo, in the south of S„o Miguel Island. Throughout the historical bibliography this species is a constant presence in deep water tows in the Azorean deep waters. For example, Koehler (1895a, 1898) described a new species Palaeotropus hirondellei based on material collected in the Azores by Hirondelle (sta 102: 38°23'45"N, 28°31'16"W, 927 m). H.L. Clark (1917) argued that Koehler overlooked Palaeotropus josephinae described by Lovén from the same area, that both species portrayed animals of different sizes, and synonymized the two species, an opinion shared by later authors (e.g., Mortensen 1950; Mironov 2006).
description: Published as part of Madeira, Patrícia, Kroh, Andreas, Cordeiro, Ricardo, De, António M., Martins, Frias & Ávila, Sérgio P., 2019, The Echinoderm Fauna of the Azores (NE Atlantic Ocean), pp. 1-231 in Zootaxa 4639 (1) on page 125, DOI: 10.11646/zootaxa.4639.1, http://zenodo.org/record/3342161
Harris & Co. v. Golding (4); Victoria; 1861.87
Creators: name: (:Null)
Publisher: name: The University of British Columbia
Year: 2019

description: No. of Plaint – 856 Summons; Invoice for £26.10.1; Bill of Costs for £3.5.0; Judgment Confessed - Golding is summoned to appear in court to answer the Plaintiff for the total amount of £29.5.11. The amount is due various goods sold to the Defendant by the Plaintiffs.
Additional file 1: of Living alone predicts mortality in patients with ischemic stroke before 70 years of age: a long-term prospective follow-up study
Creators: name: Redfors, Petra
name: IsaksĂŠn, Daniella
name: Lappas, Georgios
name: Blomstrand, Christian
name: Rosengren, Annika
name: Jood, Katarina
name: Jern, Christina
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Computational Biology

description: Supporting information. Table S1. Baseline 368 characteristics for cases and controls, and stratified by living situation for 369 controls. Table S2. Cox regression analyses investigating predictors of 370 vascular mortality for cases. (DOCX 171 kb)
Additional file 1: Table S1. of Characteristics of invasive Acinetobacter species isolates recovered in a pediatric academic center
Creators: name: Avish Jain
name: Harding, Christian
name: Kaivon Assani
name: Shrestha, Chandra
name: Mercedees Haga
name: Leber, Amy
name: Munson, Robert
name: Kopp, Benjamin
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Frequency of antibiotic regimens utilized during treatment of infected patients. Description: Breakdown of antibiotic choices utilized clinically during the first 48Â h of suspected Acinetobacter infection as well as the final treatment choices. (DOC 33Â kb)
Glucose monitoring measuring blood glucose using vertical cavity surface emitting lasers (VCSELs)
Creators: name: Talebi Fard, Sahba
Publisher: name: University of British Columbia
Year: 2008

description: Diabetes Mellitus is a common chronic disease that is an ever-increasing public health issue. Continuous glucose monitoring has been shown to help diabetes mellitus patients stabilize their glucose levels, leading to improved patient health. Hence, a glucose sensor, capable of continuous real-time monitoring, has been a topic of research for three decades. Current methods of glucose monitoring, however, require taking blood samples several times a day, hence patient compliance is an issue. Optical methods are one of the painless and promising methods that can be used for blood glucose predictions. However, having accuracies lower than what is acceptable clinically has been a major concern. To improve on the accuracy of the predictions, the signal-to-noise ratio in the spectrum can be increased, for which the use of thermally tunable vertical cavity surface emitting lasers (VCSELs) as the light source to obtain blood absorption spectra, along with a multivariate technique (Partial Least Square (PLS) techniques) for analysis, is proposed. VCSELs are semiconductor lasers with small dimensions and low power consumption, which makes them suitable for implants. VCSELs provide higher signal-to-noise ratio as they have high power spectral density and operate within a small spectrum. In the current research, experiments were run for the preliminary investigations to demonstrate the feasibility of the proposed technique for glucose monitoring. This research involves preliminary investigations for developing a novel optical system for accurate measurement of glucose concentration. Experiments in aqueous glucose solutions were designed to demonstrate the feasibility of the proposed technique for glucose monitoring. In addition, multivariate techniques, such as PLS, were customized for various specific purposes of this project and its preliminary investigation. This research will lead to the development of a small, low power, implantable optical sensor for diabetes patients, which will be a major breakthrough in the area of treating diabetes patients, upon successful completion of this research and development of the device.
Aceste bellidifera Thomson 1877
Creators: name: Madeira, Patrícia
name: Kroh, Andreas
name: Cordeiro, Ricardo
name: De, António M.
name: Martins, Frias
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Echinoidea
Spatangoida
Schizasteridae
Aceste
Aceste bellidifera

description: Aceste bellidifera Thomson, 1877
Reports for the Azores:
Aceste bellidifera Thomson, 1877 — $ Koehler 1909: 246–247; Mortensen 1927a: 321; García-Diez et al. 2005: 51; Mironov 2006: 115, 2014: 127.
Type locality: off Gomera Island, Canaries.
See: Thomson (1877: 349–351, figs. 95–96); Mortensen (1950: 332–333, figs. 224, 225).
Occurrence: Atlantic, in the west recorded from the USA (c. 37°N) and the Caribbean to southern America, and Tristan da Cunha (Agassiz 1881, Serafy & Fell 1985, Mironov 2014); in the east recorded from the Iberian Basin (Mironov 2014), Morocco (Mortensen 1927b), Josephine Seamount (Mironov 2006), the Azores (Koehler 1909) and Canaries (Thomson 1877).
Depth: 550– 5,400 m (Serafy & Fell 1985, Mironov 2014); AZO: 1,360 m (Koehler 1909).
Habitat: buried on soft substrates, mud to sandy mud and shells (Agassiz 1881, Pawson & Pawson 2013).
Remarks: the record of Aceste bellidifera in the Azores is based on a single small specimen (= 14 mm TL) identified by Koehler (1909) among the material collected by Princesse Alice (sta 703: 39°21’20”N, 31°05’45”W, 1,360 m).
description: Published as part of Madeira, Patrícia, Kroh, Andreas, Cordeiro, Ricardo, De, António M., Martins, Frias & Ávila, Sérgio P., 2019, The Echinoderm Fauna of the Azores (NE Atlantic Ocean), pp. 1-231 in Zootaxa 4639 (1) on page 130, DOI: 10.11646/zootaxa.4639.1, http://zenodo.org/record/3342161
Additional file 2: Table S2. of Dual leucine zipper kinase regulates expression of axon guidance genes in mouse neuronal cells
Creators: name: Blondeau, Andréanne
name: Jean-François Lucier
name: Matteau, Dominick
name: Lauralyne Dumont
name: Rodrigue, Sébastien
name: Pierre-Étienne Jacques
name: Blouin, Richard
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Transcriptome read statistics. (PDF 49 kb)
Additional file 3: Table S3. of Dual leucine zipper kinase regulates expression of axon guidance genes in mouse neuronal cells
Creators: name: Blondeau, Andréanne
name: Jean-François Lucier
name: Matteau, Dominick
name: Lauralyne Dumont
name: Rodrigue, Sébastien
name: Pierre-Étienne Jacques
name: Blouin, Richard
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Genes up-regulated by two-fold or more in DLK-depleted cells. (PDF 103 kb)
Additional file 2: of Characteristics of invasive Acinetobacter species isolates recovered in a pediatric academic center
Creators: name: Avish Jain
name: Harding, Christian
name: Kaivon Assani
name: Shrestha, Chandra
name: Mercedees Haga
name: Leber, Amy
name: Munson, Robert
name: Kopp, Benjamin
Publisher: name: Figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: rpoB sequences from Acinetobacter isolates. Description: Full rpoB sequences from each Acinetobacter isolate in the study. (DOC 41Â kb)
Echinocyamus scaber subsp. macrostomus Mortensen 1907
Creators: name: Madeira, Patrícia
name: Kroh, Andreas
name: Cordeiro, Ricardo
name: De, António M.
name: Martins, Frias
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Echinoidea
Clypeasteroida
Echinocyamidae
Echinocyamus
Echinocyamus scaber
Echinocyamus scaber macrostomus mortensen, 1907

description: Echinocyamus scaber macrostomus Mortensen, 1907
Reports for the Azores
Echinocyamus macrostomus $ Mortensen, 1907: 36–37, pl. 12, figs. 2, 7, 17, 24; $ Koehler 1909: 235, pl. 4, figs. 9–10; Mortensen 1927a: 315, 1948: 183–184; García-Diez et al. 2005: 51; Madeira et al. 2011: 255;
Echinocyamus scaber macrostomus Mortensen, 1907 — $ Mironov & Sagaidachny 1984: 186–187, fig. 2.2; Mironov 2006: 113– 114; Mironov 2014: 124.
See: Mortensen (1907; 1927b: 30–31); Mironov & Sagaidachny (1984).
Occurrence: North Atlantic, in the west from the Blake Plateau to Cuba (Mironov 2014), in the east from Portugal to Cape Verde (Mortensen 1907, 1927b) including the archipelagos of the Azores and Madeira (Mortensen 1907) and the Josephine, Tropic and Meteor seamounts (Mironov 2006). The subspecies E. scaber scaber de Meijere, 1903 is reported from the Indo-Pacific (Mironov & Sagaidachny 1984).
Depth: 1,010 –2,820 m, though bare tests have been reported as deep as 3,140 m (Mironov & Sagaidachny 1984); AZO: 1,560 –2,178 m (Mortensen 1907, Koehler 1909).
Habitat: mud to sand (Koehler 1909).
Remarks: Mortensen (1907) described two species of Echinocyamus, E. macrostomus and E. grandiporus using material, which included animals collected in Azorean deep waters. Mortensen (1907) considered his two new deep-water species closely related though E. macrostomus tended to live in deeper waters. In contrast, Mironov & Sagaidachny (1984) considered E. macrostomus closely related with E. scaber and downgraded Mortensen species to a variety of the later. Additionally, Mironov (2006) observed that some of the specimens from Meteor and Antialtair seamounts presented intermediate characteristics between this subspecies and E. grandiporus, suggesting that they could represent hybrids.
description: Published as part of Madeira, Patrícia, Kroh, Andreas, Cordeiro, Ricardo, De, António M., Martins, Frias & Ávila, Sérgio P., 2019, The Echinoderm Fauna of the Azores (NE Atlantic Ocean), pp. 1-231 in Zootaxa 4639 (1) on pages 134-135, DOI: 10.11646/zootaxa.4639.1, http://zenodo.org/record/3342161
Harvey v. Golding (3); Victoria; 1861.39
Creators: name: (:Null)
Publisher: name: The University of British Columbia
Year: 2019

description: No. of Plaint – 841 Summons; Invoice for £4.17.11; Judgment Confessed - Golding is summoned to appear in court to answer the Plaintiff for the total amount of £5.4.7. The amount is due for money lent to the Defendant by the Plaintiff.
Chiridota abyssicola $ Marenzeller 1892
Creators: name: Madeira, Patrícia
name: Kroh, Andreas
name: Cordeiro, Ricardo
name: De, António M.
name: Martins, Frias
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Holothuroidea
Apodida
Chiridotidae
Chiridota
Chiridota abyssicola

description: Chiridota abyssicola Marenzeller, 1892
Reports for the Azores:
Chiridota abyssicola $ Marenzeller, 1892: 65, 1893: 19, pl. 1, fig. 5, pl. 2, fig. 7; Perrier 1902: 276; Mortensen 1927a: 437; García-Diez et al. 2005: 52;
p.p. Chiridota laevis (Fabricius) —H.L. Clark 1907: 28–29.
Type locality: North of the Azores (41°40’41”N, 26°44’09”W).
See: Marenzeller (1893); H.L. Clark (1907: 119–120, as Chiridota laevis).
Occurrence: known only from the Azores (Marenzeller 1893).
Depth: AZO: 2,870 m (Marenzeller 1893).
Habitat: soft substrates (clayish sand; Marenzeller 1893).
Remarks: Marenzeller (1892, 1893) described Chiridota abyssicola based on a single specimen collected by Hirondelle within the archipelago waters (sta 248: 41°40’41”N, 26°44’9”W, 2,870 m). This species is known only from the type specimen. In a review of apodous holothurians, H.L. Clark (1907) united under the name C. laevis several species described from both the Atlantic and Pacific, turning a species previously known only to the Antarctic shallow waters to one of the most widely distributed species of the genus Chiridota, both in terms of geographic and bathymetric range. Notwithstanding, the same author believed that among the shallow and deep-water forms there was more than one species. However, the variability of the diagnostic characters was such (often depending on the age and size of the animal) that H.L. Clark was unable to clearly define each of the species. The decision of making C. abyssicola conspecific with C. laevis did not reunite consensus as the latter was viewed as a cold shallow-water species (e.g., Mortensen 1927a; Deichmann 1930; Heding 1935). Regardless, whether C. abyssicola should be merged with the highly variable C. laevis will depend on future work. For now, we have chosen to retain the historical species, restricted to the Azorean deep waters.
description: Published as part of Madeira, Patrícia, Kroh, Andreas, Cordeiro, Ricardo, De, António M., Martins, Frias & Ávila, Sérgio P., 2019, The Echinoderm Fauna of the Azores (NE Atlantic Ocean), pp. 1-231 in Zootaxa 4639 (1) on page 135, DOI: 10.11646/zootaxa.4639.1, http://zenodo.org/record/3342161
Modeling mammary epithelial cell polarization and the role of podocalyxin in breast tumor progression
Creators: name: Graves, Marcia Lynn
Publisher: name: University of British Columbia
Year: 2008

description: The mammary gland consists of an organized network of epithelial ducts and lobules. This histoarchitecture can be recapitulated in vitro by culturing mammary epithelial cells as 3D spheroids embedded in a reconstituted basement membrane. I first used this assay to characterize the role of cell-cell and cell-ECM adhesion in the formation and polarization of the apical junction complexes in normal mammary epithelial cells. Cell-cell adhesion alone was sufficient to initiate polarized junction assembly. However, the addition of exogenous ECM generated a spatial polarity signal dependent on laminin-1 and α6 and β1 integrins. This caused clusters of mammary epithelial cells to re-localize the junctional complexes to the center of the spheroid prior to lumen formation. In ductal breast carcinoma, a critical hallmark is the loss of normal polarized tissue architecture without the induction of an epithelial-to-mesenchymal transformation (EMT). Thus, misregulation of molecules that function as polarity determinants may contribute to ductal tumor progression. Podocalyxin is an anti-adhesive glycoprotein that may be involved, as it is important in epithelial morphogenesis, and its overexpression in clinical breast tumors is associated with poor outcome. Despite this, overexpression of podocalyxin in normal mammary epithelial cells did not disrupt 3D morphogenesis or apicobasal polarity. However, its overexpression in non-metastatic breast tumor cells did perturb the architecture and growth of tumor spheroids in vitro and it facilitated subcutaneous tumor growth in vivo without causing an EMT. Mechanistically, podocalyxin localized to and expanded non-adhesive membrane domains and induced microvillus formation that was dependent on its extracellular domain and Rho GTPase-regulated actin polymerization. Podocalyxin also recruited its intracellular binding partners NHERF-1 and ezrin via its cytoplasmic tail. Strikingly, the formation of this protein complex was not required for microvillus formation. Additionally, podocalyxin delayed cell-cell aggregation and decreased the initial adhesion, spreading and strength of attachment of tumor cells to fibronectin where it restricted β1 integrin localization to the basal/attached domain. These alterations in adhesion possibly contributed to podocalyxin's ability to increase growth factor-dependent tumor cell migration. Altogether, these data indicate that podocalyxin overexpression may facilitate a ductal tumor-like progression that involves EMT-independent alterations in tissue architecture.
Hoffman v. Felker (1); Victoria; 1861.58
Creators: name: (:Null)
Publisher: name: The University of British Columbia
Year: 2019

description: No. of Plaint – 738 Summons - Felker is summoned to appear in court to answer the Plaintiff for the total amount of £8.0.6. The particulars for what the amount is due for are not indicated.
Leptosynapta inhaerens
Creators: name: Madeira, Patrícia
name: Kroh, Andreas
name: Cordeiro, Ricardo
name: De, António M.
name: Martins, Frias
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Holothuroidea
Apodida
Synaptidae
Leptosynapta
Leptosynapta inhaerens

description: Leptosynapta inhaerens (Müller, 1776)
Reports for the Azores:
Leptosynapta inhaerens (M̹ller, 1776)— $ Wirtz 2009: 48, fig. 1e.
Type locality: Norway.
See: Tortonese (1965: 104–105, fig. 45); Picton (1993: 82–83).
Occurrence: Mediterranean Sea and Northeast Atlantic; from Scandinavian arctic waters south along European coasts (Tortonese 1965) to the Azores (Wirtz 2009) and Canaries (Pérez-Ruzafa et al. 1992a).
Depth: 0–173 m, mostly between the first few meters and 50 m deep (Pérez-Ruzafa et al. 1992a); also found in tide-pools (AZO; Wirtz 2009).
Habitat: soft sediments buried in muddy sand or gravel, and amongst Zostera and Caulerpa and in sandy tide pools (Picton 1993, Pérez-Ruzafa et al. 1992a).
Larval stage: Planktotrophic, hermaphroditic (Mortensen 1927 a, McEdward & Miner 2001).
Remarks: recently, Wirtz (2009) discovered small specimens belonging to Leptosynapta inhaerens in tidepools in Faial Island, turning the archipelago to the westernmost limit for this species.
description: Published as part of Madeira, Patrícia, Kroh, Andreas, Cordeiro, Ricardo, De, António M., Martins, Frias & Ávila, Sérgio P., 2019, The Echinoderm Fauna of the Azores (NE Atlantic Ocean), pp. 1-231 in Zootaxa 4639 (1) on pages 135-136, DOI: 10.11646/zootaxa.4639.1, http://zenodo.org/record/3342161
Abyssocucumis abyssorum Cosmo
Creators: name: Madeira, Patrícia
name: Kroh, Andreas
name: Cordeiro, Ricardo
name: De, António M.
name: Martins, Frias
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Holothuroidea
Dendrochirotida
Cucumariidae
Abyssocucumis
Abyssocucumis abyssorum

description: Abyssocucumis abyssorum (Théel, 1886a)
Reports for the Azores:
Cucumaria abyssorum Théel, 1886 a— $ Marenzeller 1892: 64, 1893: 14; Ludwig 1894: 122–127, pl. 9, figs. 28, 29, pl. 13, figs. 1–5; Perrier 1902: 275; Mortensen 1927a: 396; Deichmann 1930: 139; Grieg 1932: 11, fig. 9; $ Cherbonnier 1941: 93–103, figs. 1, 3; Abyssocucumis abyssorum (Théel, 1886) — García-Diez et al. 2005: 51.
Type locality: off Crozet Island (46°16’S, 48°27’E).
See: Théel (1886a: 66–67 pl. 4, fig. 6, pl. 16, fig. 6); Heding (1942: 33–35, figs. 34–36); Massin & Hendrickx (2011: 418).
Occurrence: cosmopolitan, known from all oceans except in the Arctic (Hansen 1975); in the Atlantic from the Davis Strait (Heding 1942) eastwards from south of Iceland (Deichmann 1930) and the Rockall Trough (Gage et al. 1985) to the Azores (Marenzeller 1892).
Depth: 869– 4,810 m (Gage et al. 1985); AZO: 2,870 m (Marenzeller 1892).
Habitat: soft substrates (muddy sand to ooze; Théel 1886a, Marenzeller 1892).
Remarks: the presence of this species in Azores is based on a single dredge by Hirondelle (sta 248: 41°40’41”N, 26°44’9”W) (Marenzeller 1892, 1893). Though this abyssal holothurian was never re-collected again in the archipelago, more recently A. abyssorum was repeatedly retrieved from the Mid-Atlantic Ridge just north of the Azorean waters (Gebruk 2008; Rogacheva et al. 2013).
description: Published as part of Madeira, Patrícia, Kroh, Andreas, Cordeiro, Ricardo, De, António M., Martins, Frias & Ávila, Sérgio P., 2019, The Echinoderm Fauna of the Azores (NE Atlantic Ocean), pp. 1-231 in Zootaxa 4639 (1) on page 136, DOI: 10.11646/zootaxa.4639.1, http://zenodo.org/record/3342161
Phased Array Antennas
Creators: name: Giannakopoulos, Georgios
name: Shaikh, Khushbu Mehboob
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 400601
subject: Antennas and propagation
classificationCode: 400602
subject: Data communications
classificationCode: 400606
subject: Satellite communications
classificationCode: 400607
subject: Signal processing
classificationCode: 400608
subject: Wireless communication systems and technologies (incl. microwave and millimetrewave)
classificationCode: 400699
subject: Communications engineering not elsewhere classified
classificationCode: 400807
subject: Engineering electromagnetics
classificationCode: 400913
subject: Radio frequency engineering
classificationCode: 510301
subject: Acoustics and acoustical devices; waves
classificationCode: 510399
subject: Classical physics not elsewhere classified
classificationCode: 510303
subject: Electrostatics and electrodynamics
classificationCode: 510407
subject: Surface properties of condensed matter

description: This paper demonstrates and compares the Planar Arrays (2D) and the Conformal Arrays (3D). The 3D surfaces and topography of these applications have allowed for more frequent and high scale design. Analysing conformal antennas are a technology that has been utilized for electromagnetic emitting devices. The architectural considerations and design elements for vehicles and devices have yielded potential communication benefits. The ascent of 3D printing in this space continues the revolutionary technology that will increase electromagnetic communication without any interference. Producing conformal antennas with 3D printing and additive manufacturing technology is possible due to the advantages in signal to noise ratio and power consumption. Potentials and problems are explained in detail.
Pawsonia saxicola ? (Brady & Robertson 1871
Creators: name: Madeira, Patrícia
name: Kroh, Andreas
name: Cordeiro, Ricardo
name: De, António M.
name: Martins, Frias
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Holothuroidea
Dendrochirotida
Cucumariidae
Pawsonia
Pawsonia saxicola

description: Pawsonia saxicola? (Brady & Robertson, 1871)
Reports for the Azores:
Cucumaria montagui (Fleming, 1828) — $ Marenzeller 1892: 65, 1893: 15–17; Perrier 1902: 275; Koehler 1921b: 150–152, fig. 101;
Cucumaria saxicola Brady & Robertson, 1871 — Mortensen 1927a: 401–402, fig. 240; Tortonese 1965: 75–76;
Pawsonia saxicola (Brady & Robertson, 1871) — Pérez-Ruzafa et al. 1992a: 167; Pereira 1997: 333; García-Diez et al. 2005: 51; Micael & Costa 2010: 323; Micael et al. 2012: 4.
Type locality: Ireland.
See: Brady & Robertson (1871: 690–691, pl. 71, figs. 1–4, as Cucumaria saxicola); McKenzie (1991: 156–157, figs. 8e–i).
Occurrence: Mediterranean Sea and northeast Atlantic, from the British Islands (McKenzie 1991) to the Canaries (Hernández et al. 2013) and? Azores.
Depth: 0–50 m (McKenzie 1991);? AZO: 130 m (Marenzeller 1892).
Habitat: in rock crevices, under stones or among algae (Picton 1993).
Larval stage: lecithotrophic (Newth 1916).
Remarks: during the late 19 and early 20 th centuries, a serious debate took place to decide if Cucumaria montagui was a valid species or a junior synonym of Pawsonia saxicola or Aslia lefevrei (e.g., Marenzeller 1893; Norman 1905; Orton 1914). Cucumaria montagui was reported from the Azores by Marenzeller (1892, 1893) based on the material collected by Hirondelle on a station located in the channel between Pico and Faial islands, at a depth of 130 m. Marenzeller proved later to be incorrect on the use of the name ‘montagui’ for this cucumarid, and the report from the Azores was accepted under the synonymy of P. saxicola in later works. In his review, McKenzie (1991) considered that the depth of the Azorean record was far too deep for this shallow-water species and suggested that it could be a result of a misidentification. However, it is hard to believe that Marenzeller, who was very familiar with the forms we now know as P. saxicola could have misidentified the species. Among the fauna collected by Hirondelle at this station, we find a collection of animals belonging to the shallow-water realm such as Thyone inermis (see below), a species with a depth range very similar to P. saxicola. This suggests that the depth at which these holothurians were collected could have been much shallower than the reported 130 m. Regardless, this species was never recollected in the archipelago and thus the inclusion of P. saxicola in the Azorean fauna should be considered with caution.
description: Published as part of Madeira, Patrícia, Kroh, Andreas, Cordeiro, Ricardo, De, António M., Martins, Frias & Ávila, Sérgio P., 2019, The Echinoderm Fauna of the Azores (NE Atlantic Ocean), pp. 1-231 in Zootaxa 4639 (1) on pages 136-137, DOI: 10.11646/zootaxa.4639.1, http://zenodo.org/record/3342161
Additional file 2: of Association of markers of endothelial dysregulation Ang1 and Ang2 with acute kidney injury in critically ill patients
Creators: name: Cassianne Robinson-Cohen
name: Katz, Ronit
name: Price, Brenda
name: Harju-Baker, Susanna
name: Mikacenic, Carmen
name: Himmelfarb, Jonathan
name: W. Liles
name: Wurfel, Mark
Publisher: name: Figshare
Year: 2016
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Marine Biology
subject: Cancer
subject: Computational Biology

description: Associations of biomarkers with AKI (Stage 2â  3 versus no AKI). For associations of biomarkers with the risk of AKI, we examined associations of biomarkers with severe AKI, to increase specificity of the outcome definition. (DOCX 15Â kb)
Additional file 2: Table S2. of Interleukin-36γ is expressed by neutrophils and can activate microglia, but has no role in experimental autoimmune encephalomyelitis
Creators: name: Bozoyan, Lusine
name: Dumas, Aline
name: Patenaude, Alexandre
name: Vallières, Luc
Publisher: name: Figshare
Year: 2015
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Primers used for qRT-PCR. (PDF 38 kb)
Potamonautes
Creators: name: Meyer, Kirstin S.
name: Cumberlidge, Neil
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Potamonautidae
Potamonautes

description: Key to species of Potamonautes in Lake Kivu (Cumberlidge & Meyer 2011) and its drainage basin (present work)
1. Postfrontal crest complete, either distinct or faint............................................................ 2
- Postfrontal crest either incomplete or absent................................................................ 4
2. Anterolateral margin toothed; s3/s4 incomplete, not meeting top of sac; exorbital tooth large, pointed....... P. lirrangensis
- Anterolateral margin smooth; s3/s4 complete, meeting top of sac; exorbital tooth either small or reduced to granule....... 3
3. Mandibular palp with small hard flap at junction between segments; lateral fold of G1 terminal article higher than medial fold.............................................................................................. P. minor
- Mandibular palp simple, lacking hard flap at junction between segments; medial fold of G1 terminal article higher than lateral fold...................................................................................... P. perparvus
4. Medial and lateral margins of dorsal membrane of G1 uneven; s2/s3 faint or incomplete............................ 5
- Medial and lateral margins of dorsal membrane of G1 even; s2/s3 deep, completely crossing sternum................. 6
5. Distal meral tooth of P1 merus reduced to granule; terminal article of G1 slim, straight, tapering evenly to tip. P. bourgaultae
- Distal meral tooth of P1 merus distinct, pointed; terminal article of G1 slim at base, significantly widened in middle, tapering sharply to narrow tip...................................................................... P. gonocristatus
6. s3/s4 complete, meeting top of sac; G1 terminal article straight....................................... P. idjwiensis
- s3/s4 incomplete, not meeting top of sac; G1 terminal article curved............................................ 7
7. First carpal tooth low, blunt; subterminal segment of G1 with setose margins.......................... P. muta nd ensis
- First carpal tooth distinct, pointed; subterminal article of G1 lacking setae.............................. P. semilunaris
description: Published as part of Meyer, Kirstin S. & Cumberlidge, Neil, 2011, A revision of the freshwater crabs (Crustacea: Decapoda: Brachyura: Potamonautidae) of the Lake Kivu drainage basin in Central and East Africa, pp. 45-58 in Zootaxa 3011 on page 57, DOI: 10.5281/zenodo.207971
Comparison of pregnancy rates, progesterone concentrations, and expression of genes associated with progesterone synthesis in heifers and mature cows
Creators: name: Balendran, Anusha
Publisher: name: University of British Columbia
Year: 2008

description: It has been reported world wide that over the past fifty years production has dramatically increased in dairy cattle but at the same time fertility rates have steadily declined, particularly in mature cows. Fertility of heifers that were bred for the first time has not been affected. One of the major reasons for such fertility decline in mature cows could be impaired progesterone production. Therefore relationships of parity with reproductive performance, its effect on progesterone concentrations and genes associated with progesterone synthesis were examined in this thesis. In the first experiment, breeding records of 163 Holstein heifers and cows in 1st, 2nd, and 3rd/4th parities were used to compare pregnancy rates among heifers and parity cows and between parity cows. Progesterone levels of heifers, 1st, 2nd, and 3rd/4th parity (10 animals each group) were measured from milk and blood samples. First and second inseminations pregnancy rates were higher in heifers compared to other parity cows. Furthermore 1st parity cows showed higher pregnancy rates than 2nd and 3rd/4th parity cows. However, P₄ levels were not significantly different among animals of different parity. In the second experiment, expression levels of steroidogenic genes – StAR, P450scc, 3-β HSD; apoptotic genes Bax and Bcl-2; and HSP70 in corpus luteum obtained from six heifers and three 2nd/3rd parity lactating cows were compared using RT-PCR. Relative optical density with house keeping gene was obtained for each gene. Analysis of variance revealed that expression levels of steroidogenic and Bax genes are higher (p<0.05) in cows than heifers. HSP70 gene and Bcl-2 gene expressions were not different (P>0.05) between the two groups. This study confirmed a clear relationship between parity and reproductive performance. There was no significance relationship between parity and circulating progesterone levels. Steroidogenic genes expression was higher in lactating cows than heifers and no differences were seen in mRNA levels of Bcl2, and HSP70 genes between heifers and mature cows. Bax mRNA expression was higher in mature cows suggesting that the lifespan of corpus luteum may be compromised in 2nd and 3rd parity cows, resulting in early embryonic mortality and reduced pregnancy rates.