cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The role of glucocorticoid receptor and oxytocin receptor in the septic heart in a clinically relevant, resuscitated porcine model with underlying atherosclerosis
Creators: name: Merz, Tamara
name: Denoix, Nicole
name: Wigger, Daniela
name: Waller, Christiane
name: Wepler, Martin
name: Vettorazzi, Sabine
name: Tuckermann, Jan Peter Gottfried
name: Radermacher, Peter
name: McCook, Oscar
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: DDC 610 / Medicine & health
subject: Heart
subject: Receptors, Oxytocin
subject: Receptors, Glucocorticoid
subject: Cystathionine gamma-Lyase
subject: Oxidative stress
subject: Inflammation
subject: Sepsis
subject: Glucocorticosteroidrezeptor
subject: Oxidativer Stress
subject: Entzündung
subject: Cystathioninlyase

description: The pathophysiology of sepsis-induced myocardial dysfunction is not resolved to date and comprises inflammation, barrier dysfunction and oxidative stress. Disease-associated reduction of tissue cystathionine-γ-lyase (CSE) expression, an endogenous H2S-producing enzyme, is associated with oxidative stress, barrier dysfunction and organ injury. CSE-mediated cardio-protection has been suggested to be related the upregulation of oxytocin receptor (OTR). CSE can also mediate glucocorticoid receptor (GR) signaling, which is important for normal heart function. A sepsis-related loss of cardiac CSE expression associated with impaired organ function has been reported previously. The aim of this current post hoc study was to investigate the role of cardiac GR and OTR after polymicrobial sepsis in a clinically relevant, resuscitated, atherosclerotic porcine model. Anesthetized and instrumented FBM (Familial Hypercholesterolemia Bretoncelles Meishan) pigs with high fat diet-induced atherosclerosis underwent poly-microbial septic shock (n = 8) or sham procedure (n = 5), and subsequently received intensive care therapy with fluid and noradrenaline administration for 24 h. Cardiac protein expression and mRNA levels were analyzed. Systemic troponin, a marker of cardiac injury, was significantly increased in septic animals in contrast to sham, whereas OTR and GR expression in septic hearts were reduced, along with a down-regulation of anti-inflammatory GR target genes and the antioxidant transcription factor NRF2. These results suggest a potential interplay between GR, CSE, and OTR in sepsis-mediated oxidative stress, inflammation and cardiac dysfunction.
German evidence- and consensus-based guideline on the management of penile urethritis
Creators: name: Werner, Ricardo Niklas
name: Sunderkötter, Cord
name: [Und Viele Weitere]
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2025
Subjects: subject: 610

description: Urethritis is a common condition predominantly caused by sexually transmitted pathogens such as Chlamydia trachomatis, Neisseria gonorrhoeae, and Mycoplasma genitalium. It is not possible to differentiate with certainty between pathogens on the basis of clinical characteristics alone. However, empirical antibiotic therapy is often initiated in clinical practice. The aim of this clinical practice guideline is to promote an evidence-based syndrome-orientated approach to the management of male adolescents and adults with symptoms of urethritis. Besides recommendations for the diagnosis, classification and choice of treatment, this guideline provides recommendations for the indication to empirically treat patients with penile urethritis. A novel feature compared to existing, pathogen-specific guidelines is the inclusion of a flowchart for the syndrome-orientated practical management. For suspected gonococcal urethritis requiring empirical treatment, ceftriaxone is recommended. Due to the risk of Chlamydia trachomatis co-infection, doxycycline should also be prescribed, unless follow-up for the treatment of possible co-infections is assured. For suspected non-gonococcal urethritis, doxycycline is the recommended empirical treatment. In the empiric treatment of both gonococcal and non-gonococcal penile urethritis, azithromycin is reserved for cases where doxycycline is contraindicated. This guideline also includes detailed recommendations on differential diagnosis, pathogen-specific treatments and specific situations, as well as patient counselling and follow-up.
Additional file 2 of Activities used by evidence networks to promote evidence-informed decision-making in the health sector– a rapid evidence review
Creators: name: Garavito, Germán Andrés Alarcón
name: Moniz, Thomas
name: Mansilla, Cristián
name: Iqbal, Syka
name: Dobrogowska, Rozalia
name: Bennin, Fiona
name: Talwar, Shivangi
name: Khalid, Ahmad Firas
name: Vindrola-Padros, Cecilia
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary material 2.
Redescription of the commercially harvested jellyfish, Crambionella orsini and Lobonemoides gracilis (Cnidaria: Scyphozoa) from Sri Lanka
Creators: name: Karunarathne, Krishan D.
name: Amaya, H.K.T.
name: Digamadulla, D.S.
name: de Croos, M.D.S.T.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Plant Biology

description: Two types of edible jellyfish, namely ‘ball-type’ and ‘white-type’, were reported to be commercially harvested respectively from the southeast and northwest coasts of Sri Lanka, but their taxonomic identity was unknown. Therefore, medusae collected in the ‘Waya-jel-Survey’, together with specimens from museums, were examined, comparing their morphomeristic data with information from the literature. As per results, the ‘ball-type’ and ‘white-type’ jellyfish species were recognized respectively as Crambionella orsini (Vanhöffen 1888) and Lobonemoides gracilis Light 1914 for the first time from Sri Lanka, with a detailed account of morphological features. Among the four valid species of the genus Crambionella, C. orsini is distinguished by the presence of 16 velar lappets per octant, without tubercles. The two congeners of L. gracilis, namely L. robustus Stiasny 1920 and L. sewelli Rao 1931, were synonymized to L. gracilis, making Lobonemoides monospecific, thus L. gracilis is recognized by the presence of papillae on the exumbrella; 1–6 elongated velar lappets between two successive rhopalia; and the window-like openings and long, spindle-shaped appendages on the oral arms. Likewise, the present study re-describes C. orsini and L. gracilis providing a basic component for efficient management of jellyfish fishery resources in Sri Lanka as well as in other Asian countries.
Exterior powers in Iwasawa theory
Creators: name: Bleher, F.
name: Chinburg, T.
name: Greenberg, R.
name: Kakde, M.
name: Sharifi, R.
name: Taylor, M.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11R23, 11R34

description: The Iwasawa theory of CM fields has traditionally concerned Iwasawa modules that are abelian pro-p Galois groups with ramification allowed at a maximal set of primes over p such that the module is torsion. A main conjecture for such an Iwasawa module describes its codimension one support in terms of a p-adic L-function attached to the primes of ramification. In this paper, we study more general and potentially much smaller Iwasawa modules that are quotients of exterior powers of Iwasawa modules with ramification at a set of primes over p by sums of exterior powers of inertia subgroups. We show that the higher codimension support of such quotients can be measured by finite collections of p-adic L-functions under the relevant CM main conjectures.
description: 41 pages, to appear in J. Eur. Math. Soc
Technology position of concentrating solar technologies in Turkiye: A review on current status, applications, and prospects
Creators: name: Yılmaz, İbrahim Halil
name: Arıcı, Müslüm
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Medicine
Cancer
Science Policy

description: Turkiye has considerable solar resources and technology capacity and thus is seeking ways to implement carbon-neutral energy policies and reduce import energy. After China, Turkiye has the world’s second-largest installed nonconcentrating collector area. Since the last quarter, significant efforts have been made in Turkiye to implement concentrated solar technologies (CST), including the world’s largest industrial solar energy cooling system and the first solar thermal trigeneration system, the first integrated renewables combined cycle, as well as more efficient two-axis tracking parabolic trough systems. This review highlights the overall status, developments, research trends, breakthroughs, technology deployment, challenges, and prospects of the commercial Turkish CST. It aims to present the historical development of CST and associated research activities conducted and ongoing in Turkiye, infrastructure of national organizations, a pathway for the alignment of national/global research and funding programs, and commercial-level contributions for the future progress of CST. It would also bridge the gap between the research and commercial deployment of CST and speed up the relevant transfer of knowledge so that researchers, institutions, companies, decision-makers, and other stakeholders in Turkiye and the world can gain a greater perspective. Although considerable efforts have been made in the Turkish CST context, ~10-MWt cumulative capacity is actively operated, of ~60% and ~32% led, respectively, by the parabolic trough and central tower receiver technologies.
sj-pdf-2-tab-10.1177_1759720X20912861 – Supplemental material for Association between platelet count and osteoarthritis in women older than 50 years
Creators: name: Kwon, Yu-Jin
name: Koh, Il-Hyun
name: Chung, Kwangho
name: Lee, Yong-Jae
name: Kim, Hyoung-Sik
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified

description: Supplemental material, sj-pdf-2-tab-10.1177_1759720X20912861 for Association between platelet count and osteoarthritis in women older than 50 years by Yu-Jin Kwon, Il-Hyun Koh, Kwangho Chung, Yong-Jae Lee and Hyoung-Sik Kim in Therapeutic Advances in Musculoskeletal Disease
sj-docx-1-spp-10.1177_19485506221119018 – Supplemental material for Collective Stressors Affect the Psychosocial Development of Young Adults
Creators: name: Bühler, Janina Larissa
name: Hopwood, Christopher J.
name: Nissen, Adam
name: Bleidorn, Wiebke
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, sj-docx-1-spp-10.1177_19485506221119018 for Collective Stressors Affect the Psychosocial Development of Young Adults by Janina Larissa Bühler, Christopher J. Hopwood, Adam Nissen and Wiebke Bleidorn in Social Psychological and Personality Science
MicroRNA expression in high-grade B-cell lymphoma with 11q aberration
Creators: name: Di Stefano, Gioia
name: Fischer, Anja
name: Chteinberg, Emil
name: Bens, Susanne
name: Wagener, Rabea
name: Abramov, Dmitriy
name: Adam, Patrick
name: Bernhart, Stephan H.
name: Borkhardt, Arndt
name: Burkhardt, Birgit
name: Höll, Jessica
name: [Und Weitere]
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2025
Subjects: subject: 610

description: Mature aggressive B-cell lymphomas, such as Burkitt lymphoma (BL) and Diffuse large B-cell lymphoma (DLBCL), show variations in microRNA (miRNA) expression. The entity of High-grade B-cell lymphoma with 11q aberration (HGBCL-11q) shares several biological features with both BL and DLBCL but data on its miRNA expression profile are yet scarce. Hence, this study aims to analyze the potential differences in miRNA expression of HGBCL-11q compared to BL and DLBCL. We evaluated the expression profiles of 2083 miRNAs in 25 HGCBL-11q, 7 BL, 131 DLBCL, and tonsils using the HTG EdgeSeq miRNA whole transcriptome assay. Uniform manifold approximation and projection (UMAP) and differential gene expression analyses based on DESeq2 were carried out. UMAP analysis of miRNA expression did not reveal distinct groups among the studied lymphomas. However, differential gene expression investigations detected sets of overexpressed miRNAs in HGBCL-11q when compared to BL (miR-9-3p, miR-9-5p, miR-3919, miR-129-1-3p, miR-129-2-3p, miR-331-3p, miR-196b-5p, and miR-28-5p) and DLBCL (miR-3919, miR-1290, miR-4538, and miR-4791), respectively. Notably, miR-3919 showed heterogeneous but significantly higher expression (p-value < 0.001) in HGBCL-11q than in both, BL and DLBCL. We identified a group of differentially expressed miRNAs between HGBCL-11q vs. BL and DLBCL, with miR-3919 as the most commonly and recurrently overexpressed miRNA in HGBCL-11q.
Additional file 3 of Activities used by evidence networks to promote evidence-informed decision-making in the health sector– a rapid evidence review
Creators: name: Garavito, Germán Andrés Alarcón
name: Moniz, Thomas
name: Mansilla, Cristián
name: Iqbal, Syka
name: Dobrogowska, Rozalia
name: Bennin, Fiona
name: Talwar, Shivangi
name: Khalid, Ahmad Firas
name: Vindrola-Padros, Cecilia
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary material 3.
Post-glacial vegetation trajectories on the Eastern Tibetan Plateau reflect millennial-scale migration lags in complex mountain terrain based on sedimentary ancient DNA and dynamic dispersal modeling
Creators: name: Sheng, Wei
name: Kruse, Stefan
name: Liu, Sisi
name: Stoof-Leichsenring, Kathleen R.
name: Kühn, Ingolf
name: Li, Wenjia
name: Cao, Xianyong
name: Zhang, Zhi-Rong
name: Zeng, Chun-Xia
name: Yang, Jun-Bo
name: Li, De-Zhu
name: Herzschuh, Ulrike
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2025
Subjects: subject: 576

description: Mountains with complex terrain and steep environmental gradients are biodiversity hotspots such as the eastern Tibetan Plateau (TP). However, it is generally assumed that mountain terrain plays a secondary role in plant species assembly on a millennial time-scale compared to climate change. Here, we investigate plant richness and community changes during the last 18,000 years at two sites: Lake Naleng and Lake Ximen on the eastern TP with similar elevation and climatic conditions but contrasting terrain. We applied plant DNA metabarcoding to lake sediments leveraging a new regional reference database for taxa identification. Furthermore, we developed a simplified species dispersal model named SMARC. This was used to simulate species migration along river valleys in response to past climate change at the taxonomic resolution of the sedimentary ancient DNA (sedaDNA) approach. Statistical analyses, including ordination-based ecological trajectory analysis, yielded a significant match between sedaDNA and simulated results at single taxon and community levels including certain site-specific differences. Steep terrain downstream of Lake Naleng enhances connectivity to glacial lowland refugia during postglacial warming. In contrast, gentle terrain over long distances implies weak connectivity to the lowland and thus resulted in a strong migration lag at Lake Ximen. Likewise, terrain differences among our sites defined the different connectivity to alpine refugia during late-Holocene cooling. Our consistent proxy- and model-based results, for the first time, indicate that dispersal related migration lags in complex mountain terrain lead to uneven vegetation trajectories at sites with similar climatic conditions mainly because of differences in connectivity to refugia. Ultimately our results indicate that connectivity to refugia is a first-order factor for species migration in addition to elevation-related climatic conditions shaping the postglacial vegetation trajectory in mountainous terrain. This has hitherto largely been ignored when forecasting mountain vegetation responses to climate change and related risk assessment.
Educación Superior Y Crecimiento Económico En Colombia (1971-2016): Una Relación De Cointegración.
Creators: name: Baron, Ortegon
Publisher: name: Zenodo
Year: 2018
Subjects: Economic growth; Human Capital; Access to higher education; Colombia; VEC model.

description: This article analyzes the relation between GDP per capita (CPIBpc) and access to tertiary education, seen from the perspective of growth rate of the number of enrollments (TCMes) in higher education in Colombia for the period (1971-2016). By using a VEC model and assuming everything else constant, it is concluded that TCMes Granger caused the Colombian GDP per capita and vice-versa, therefore, the existence of a long run relation between both variables is verified. This result helps to explain the dynamics of Colombian economic growth per capita of the last forty-five years and the impact of the accumulation of human capital on it.
description: {"references": ["Barro, R. J. (2001). Education and economic growth. The contribution of human and social capital to sustained economic growth and well-being, 14-41.", "Enders, W. (2003). Applied Econometric Time Series. John Wiley & Sons.", "EViews 10 Help Topics. (2018). Retrieved from: http://www.eviews.com/help/helpintro.html", "Gobierno de Colombia., (2018)., Descripci\u00f3n del programa 'De cero a siempre' . Recuperado el 24 de agosto de 2018 de: http://www.deceroasiempre.gov.co/QuienesSomos/Paginas/QuienesSomos.aspx", "Hamilton, J. D. (1994). Time series analysis (Vol. 2). Princeton: Princeton university press.", "Hanushek, E. A. (2013). Economic growth in developing countries: The role of human capital. Economics of Education Review, 37, 204-212.", "Hanushek, E. A. (2016). Will more higher education improve economic growth?. Oxford Review of Economic Policy, 32(4), 538-552.", "Hyndman, R. J., & Athanasopoulos, G. (2018). Forecasting: principles and practice. OTexts.", "Lin, J. (2008). Notes on testing causality. Institute of Economics, Academia Sinica, Department of Economics, National Chengchi University.", "L\u00fctkepohl, H. (2005). New introduction to multiple time series analysis. Springer Science & Business Media.", "Mercan, M., & Sezer, S. (2014). The effect of education expenditure on economic growth: The case of Turkey. Procedia-Social and Behavioral Sciences, 109(0), 925-930.", "Novales, A. (2014). Modelos vectoriales autoregresivos (VAR).", "Romer, D. (2012). Advanced macroeconomics. Fourth edition. Mac Graw Hill.", "Sosa, W. (2006). Vectores autoregresivos (VAR), curso del Banco central de Chile: Vectores Autorregresivos para Datos en Paneles. Retrieved on November 21 of 2016   from: http://faculty.udesa.edu.ar/WalterSosa/PVAR/bcchile2.pdf", "Stock, J. H., & Watson, M. W. (2001). Vector autoregressions. The Journal of Economic Perspectives, 15(4), 101-115.", "The World Bank. (2018). Database: World Development Indicators. Retrieved from http://databank.worldbank.org/data/reports.aspx?source=2&country=COL#", "Woschnagg, E & Cipan, J. (2004). Evaluating forecast accuracy. University of Vienna, Department of Economics."]}
Half a century of temperate non-forest vegetation changes : no net loss in species richness, but considerable shifts in taxonomic and functional composition
Creators: name: Klinkovská, Klára
name: Sperandii, Marta Gaia
name: Knollová, Ilona
name: Danihelka, Jiří
name: Hájek, Michal
name: Hajkova, Petra
name: Hroudová, Zdenka
name: Jiroušek, Martin
name: Lepš, Jan
name: Navrátilová, Jana
name: Peterka, Tomáš
name: Bruelheide, Helge
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2025
Subjects: subject: 580

description: In recent decades, global change and local anthropogenic pressures have severely affected natural ecosystems and their biodiversity. Although disentangling the effects of these factors is difficult, they are reflected in changes in the functional composition of plant communities. We present a comprehensive, large-scale analysis of long-term changes in plant communities of various non-forest habitat types in the Czech Republic based on 1154 vegetation-plot time series from 53 resurvey studies comprising 3909 vegetation-plot records. We focused not only on taxonomic diversity but also on the functional characteristics of communities. Species richness of most habitat types increased over time, and taxonomic and functional community composition shifted significantly. Habitat specialists and threatened species became less represented in plant communities, indicating a decline in habitat quality. The spread of trees, shrubs, tall herbaceous plants, strong competitors, and nutrient-demanding species in all non-forest habitats, coupled with the decline of light-demanding species, suggests an effect of eutrophication and natural succession following the abandonment of traditional management. Moreover, we identified specific trends in certain habitats. In wetlands, springs, and mires, moisture-demanding species decreased, probably due to drainage, river regulations, and increasing drought resulting from climate change. Dry grasslands, ruderal, weed, sand, and shallow-soil vegetation became more mesic, and successional processes were most pronounced in these communities, suggesting a stronger effect of abandonment of traditional management and eutrophication. In alpine and subalpine vegetation, meadows and mesic pastures, and heathlands, insect-pollinated species declined, and the proportion of grasses increased. Overall, these functional changes provide deep insights into the underlying drivers and help conservationists take appropriate countermeasures.
Additional file 4 of Activities used by evidence networks to promote evidence-informed decision-making in the health sector– a rapid evidence review
Creators: name: Garavito, Germán Andrés Alarcón
name: Moniz, Thomas
name: Mansilla, Cristián
name: Iqbal, Syka
name: Dobrogowska, Rozalia
name: Bennin, Fiona
name: Talwar, Shivangi
name: Khalid, Ahmad Firas
name: Vindrola-Padros, Cecilia
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary material 4.
COD1 Study Guide V1 - Extended Data File 3 - Information Capture Form_Generic.xlsx
Creators: name: Chaussabel, Damien
name: Rinchai, Darawan
Publisher: name: figshare
Year: 2022
Subjects: Biomarkers

description: A spreadsheet in the MS Excel format that is used as a template in steps 3, 4 and 5 to capture relevant information from the literature and from transcriptional profiling data analysis results
sj-docx-1-sgo-10.1177_21582440221126627 – Supplemental material for Word Instruction Techniques in Saudi EFL Classrooms: Their Use and Perceived Usefulness by Teachers
Creators: name: Alhatmi, Sultan
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications
subject: 160299 Criminology not elsewhere classified
subject: FOS: Law
subject: Education
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: Sociology
subject: FOS: Sociology

description: Supplemental material, sj-docx-1-sgo-10.1177_21582440221126627 for Word Instruction Techniques in Saudi EFL Classrooms: Their Use and Perceived Usefulness by Teachers by Sultan Alhatmi in SAGE Open
Acute respiratory tract infections during the first 6 years of life : results from the German birth cohort study LoewenKIDS
Creators: name: Klee, Bianca
name: Diexer, Sophie
name: Langer, Susan
name: Gottschick, Cornelia
name: Hartmann, Carla Johanna
name: Glaser, Nadine
name: Horn, Johannes
name: Hassan, Lamiaa Mostafa
name: Thies, Saskia
name: Mikolajczyk, Rafael
name: [Und Weitere]
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2025
Subjects: subject: 610

description: Objectives: Acute respiratory tract infections (ARIs) often occur in early childhood and are mostly self- limited. However, they impose a high socioeconomic burden and can be associated with chronic diseases later in life. To date, data on self-reported ARIs beyond infancy are limited. This study aimed to describe the incidence and characteristics of self-reported ARIs in the first 6 years of life. Methods: Data were obtained from the LoewenKIDS birth cohort study, including 782 children born be- tween 2014 and 2018. Parents recorded daily ARI symptoms, which were classified into episodes for inci- dence and characteristics analysis. Regression analyses explored the influence of exposure factors on ARI incidence. Results: This longitudinal birth cohort study of a subsample of 258 children found a mean cumulative duration of 51.5 weeks (95% confidence interval: 47.5-55.6 weeks) of respiratory symptoms in the first 6 years of life, with large individual differences. Children with frequent infections in infancy had more infections in preschool age. Exposure factors explained only a small fraction of variation in incidence (5%). Conclusions: There is a substantial variation in susceptibility to ARIs in childhood, which is not explained by exposure factors.
sj-pdf-3-imr-10.1177_03000605221126874 - Supplemental material for Fibrinogen like protein-1 knockdown suppresses the proliferation and metastasis of TU-686 cells and sensitizes laryngeal cancer to LAG-3 blockade
Creators: name: Huang, Jiameng
name: Huang, Qiang
name: Xue, Jiyao
name: Liu, Huiqin
name: Guo, Yang
name: Chen, Hui
name: Zhou, Liang
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: Health and Community Services
subject: Cardiology
subject: Dentistry not elsewhere classified
subject: Emergency Medicine
subject: Endocrinology
subject: Geriatrics and Gerontology
subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Nursing not elsewhere classified
subject: Nutrition and Dietetics not elsewhere classified
subject: Oncology and Carcinogenesis not elsewhere classified
subject: Orthopaedics
subject: Sports Medicine
subject: Otorhinolaryngology
subject: Aged Health Care
subject: Paediatrics
subject: Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: Psychology not elsewhere classified
subject: Psychiatry (incl. Psychotherapy)
subject: Public Health and Health Services not elsewhere classified
subject: Respiratory Diseases
subject: Sociological Methodology and Research Methods
subject: Surgery

description: Supplemental material, sj-pdf-3-imr-10.1177_03000605221126874 for Fibrinogen like protein-1 knockdown suppresses the proliferation and metastasis of TU-686 cells and sensitizes laryngeal cancer to LAG-3 blockade by Jiameng Huang, Qiang Huang, Jiyao Xue, Huiqin Liu, Yang Guo, Hui Chen and Liang Zhou in Journal of International Medical Research
Additional file 5 of Activities used by evidence networks to promote evidence-informed decision-making in the health sector– a rapid evidence review
Creators: name: Garavito, Germán Andrés Alarcón
name: Moniz, Thomas
name: Mansilla, Cristián
name: Iqbal, Syka
name: Dobrogowska, Rozalia
name: Bennin, Fiona
name: Talwar, Shivangi
name: Khalid, Ahmad Firas
name: Vindrola-Padros, Cecilia
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary material 5.
Segmental alterations of the corpus callosum in progressive supranuclear palsy: a multiparametric magnetic resonance imaging study
Creators: name: Müller, Hans-Peter
name: Uttner, Ingo
name: Ludolph, Albert C.
name: Pinkhardt, Elmar Hans
name: Huppertz, Hans-Jürgen
name: Kassubek, Jan Rainer
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Texture analysis
subject: Fiber tracking
subject: Parkinsonian syndromes
subject: DDC 610 / Medicine & health
subject: Supranuclear palsy, Progressive
subject: Corpus callosum
subject: Magnetic resonance imaging
subject: Diffusion tensor imaging
subject: Steele-Richardson-Olszewski-Syndrom
subject: Parkinsonismus
subject: Diffusionsgewichtete Magnetresonanztomografie

description: Background: The regional distribution of the widespread cerebral morphological alterations in progressive supranuclear palsy (PSP) is considered to include segmental parts of the corpus callosum (CC). Objective: The study was designed to investigate the regional white matter (WM) of the CC by T1 weighted magnetic resonance imaging (T1w MRI) data combined with diffusion tensor imaging (DTI) data in PSP patients, differentiated in the variants Richardson syndrome and PSP-parkinsonism, and to compare them with Parkinson’s Disease (PD) patients and healthy controls, in order to identify macro- and micro-structural alterations in vivo. Methods: MRI-based WM mapping was used to perform an operator-independent segmentation for the different CC segments in 66 PSP patients vs. 66 PD patients vs. 44 matched healthy controls. The segmentation was followed by both planimetric and texture analysis of the separated CC areas for the comparison of the three groups. Results were complemented by a DTI-based tract-of-interest analysis of the associated callosal tracts. Results: Significant alterations of the parameters entropy and homogeneity compared to controls were observed for PSP as well as for PD for the CC areas I, II, and III. The inhomogeneity in area II in the PSP cohort was the highest and differed significantly from PD. A combined score was defined as a potential marker for the different types of neurodegenerative parkinsonism; receiver operating characteristics (ROC) curves were calculated with areas under the curve values of 0.86 for PSP vs. controls, 0.72 for PD vs. controls, and 0.69 for PSP vs. PD, respectively. Conclusion: The multiparametric MRI texture and DTI analysis demonstrated extensive alterations of the frontal CC in neurodegenerative parkinsonism, whereas regional CC atrophy cannot be regarded as a constant neuroimaging feature of PSP. Specifically, the comparison PSP vs. PD revealed significant alterations in callosal area II. The combination of the texture and the DTI parameters might contribute as a neuroimaging marker for the assessment of the CC in PSP, including the differentiation vs. PD.
Development of a StIW111C-based bioresponsive pore-forming conjugate for permeabilizing the endosomal membrane
Creators: name: Escalona-Rodriguez, Felipe A.
name: La O-Bonet, Javier
name: Tasies, Lidia Priscila Ferrer
name: Subbarayan, Karthikeyan
name: Rivero-Hernández, Ada L.
name: Sifontes-Niebla, Maricary
name: Manso-Vargas, Alexis
name: De Cola, Luisa
name: Ventosa, Nora
name: Sánchez, Belinda
name: Alvarez, Carlos
name: Rivera, Daniel G.
name: Seliger, Barbara
name: Lanio, María E.
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2025
Subjects: subject: 610

description: Gene expression manipulation is pivotal in therapeutic approaches for various diseases. Non-viral delivery systems present a safer alternative to viral vectors, with reduced immunogenicity and toxicity. However, their effectiveness in promoting endosomal escape, a crucial step in gene transfer, remains limited. To address this drawback, we developed a reducible conjugate combining the StIW111C mutant of Sticholysin I, a pore-forming protein, with a polylysine peptide. This conjugate aims to enhance plasmid DNA (pDNA) release from endosomes, thereby improving gene expression. A 16-polylysine peptide was attached to StIW111C via a disulfide bridge to block its membrane-binding site, enabling controlled modulation of pore-forming activity in response to a reductive environment. This modification also enhances the conjugate's positive charge, facilitating binding to nucleic acids. Formation of positively charged nanometric complexes was achieved by mixing pDNA with the bio-responsive StIW111C conjugate and polylysine peptide. In vitro assays showed the conjugate could permeabilize endosomes, but reporter gene expression was limited, likely due to the largest complexes or aggregates that reduced conjugate entry and blocked nucleic acid release. CryoTEM imaging revealed the presence of small aggregate fraction, highlighting the need for further redesign to prevent aggregation and optimize endosomal release of non-viral systems for enhanced gene expression.
sj-docx-2-aor-10.1177_00034894231177756 – Supplemental material for Meningitis Risk and Role of Prophylactic Antibiotics in Spontaneous Lateral Skull Base CSF Leaks
Creators: name: Quimby, Alexandra E.
name: De Ravin, Emma
name: Eliades, Steven J.
name: Brant, Jason A.
name: Bigelow, Douglas
name: Ruckenstein, Michael J.
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 110315 Otorhinolaryngology
subject: FOS: Clinical medicine

description: Supplemental material, sj-docx-2-aor-10.1177_00034894231177756 for Meningitis Risk and Role of Prophylactic Antibiotics in Spontaneous Lateral Skull Base CSF Leaks by Alexandra E. Quimby, Emma De Ravin, Steven J. Eliades, Jason A. Brant, Douglas Bigelow and Michael J. Ruckenstein in Annals of Otology, Rhinology & Laryngology
title: Master–slave elimination scheme for arbitrary smooth nonlinear multi-point constraints
Creators: name: Boungard, Jonas
name: Wackerfuß, Jens
Publisher: name: Universität Kassel
Year: 2024
Subjects: subject: Nonlinear multi-point constraints
subject: Master–slave elimination
subject: Penalty method
subject: Lagrange multiplier
subject: Benchmark examples
classificationCode: 620
subject: 620
classificationCode: Penalty-Methode
subject: Penalty-Methode
classificationCode: Lagrange-Multiplikator
subject: Lagrange-Multiplikator
classificationCode: Benchmark
subject: Benchmark

description:
Nonlinear multi-point constraints are essential in modeling various engineering problems, for example in the context of (a) linking individual degrees of freedom of multiple nodes to model nonlinear joints, (b) coupling different element types in finite element analysis, (c) enforcing various types of rigidity in parts of the mesh and (d) considering deformation-dependent Dirichlet boundary conditions. One method for addressing constraints is the master–slave elimination, which offers the benefit of reducing the problem dimension as opposed to Lagrange multipliers and the penalty method.
However, the existingmaster-slave elimination method is limited to linear constraints. In this paper, we introduce a new master–slave elimination method for handling arbitrary smooth nonlinear multi-point constraints in the system of equations of the discretized system. We present a rigorous mathematical derivation of the method. Within this method, new constraints can be easily considered as an item of a “constraint library”; i.e. no case-by-case-programming is required. In addition to the theoretical aspects, we also provide helpful remarks on the efficient implementation. Among others, we show that the new method results in a reduced computational complexity compared to the existing methods. The study also places emphasis on comparing the new approach with existing methods via numerical examples. We have developed innovative benchmarks which encompass all relevant computational properties, and provide analytical and reference solutions. Our findings demonstrate that our new method is as accurate, robust and flexible as the Lagrange multipliers, and more efficient due to the reduction of the total number of degrees of freedom, which is particularly advantageous when a large number of constraints have to be considered.
sj-docx-1-pch-10.1177_21501351231213626 - Supplemental material for A Noninvasive Circulating Signature of Combined Right Ventricular Pressure and Volume Overload in Tetralogy of Fallot/Pulmonary Atresia/Major Aortopulmonary Collateral Arteries
Creators: name: Clouthier, Katie L.
name: Taylor, Anne C.
name: Xuhuai, Ji
name: Liu, Yuhan
name: Parker, Sarah
name: Van Eyk, Jennifer
name: Reddy, Sushma
Publisher: name: SAGE Journals
Year: 2023
Subjects: Cardiology
Paediatrics
Surgery

description: Supplemental material, sj-docx-1-pch-10.1177_21501351231213626 for A Noninvasive Circulating Signature of Combined Right Ventricular Pressure and Volume Overload in Tetralogy of Fallot/Pulmonary Atresia/Major Aortopulmonary Collateral Arteries by Katie L. Clouthier, Anne C. Taylor, Ji Xuhuai, Yuhan Liu, Sarah Parker, Jennifer Van Eyk and Sushma Reddy in World Journal for Pediatric and Congenital Heart Surgery
sj-doc-3-sgo-10.1177_21582440231220155 – Supplemental material for Examining the Differences Between Playoff Teams and Non-Playoff Teams in Men’s Euroleague; Play-Type Statistics Perspective
Creators: name: Akinci, Yasin
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: Communication and Media Studies not elsewhere classified
subject: Criminology not elsewhere classified
subject: Education
subject: Psychology not elsewhere classified
subject: Sociology
subject: FOS: Sociology

description: Supplemental material, sj-doc-3-sgo-10.1177_21582440231220155 for Examining the Differences Between Playoff Teams and Non-Playoff Teams in Men’s Euroleague; Play-Type Statistics Perspective by Yasin Akinci in SAGE Open
Mixed-initiative intent recognition using cloud-based cognitive services
Creators: name: Kraus, Matthias
Publisher: name: Universität Ulm
Year: 2017
Subjects: subject: Intention recognition
subject: Spoken dialogue systems
subject: DDC 004 / Data processing & computer science
subject: Human-computer interaction
subject: Prediction (Psychology); Data processing
subject: Speech processing systems
subject: Intention
subject: Automatische Spracherkennung
subject: Cloud computing

description: In spoken dialogue systems, understanding the intention of a user is essential for a succesful and natural perceived human-machine interaction. Therefore, in the scope of this thesis, the creation and evaluation of a dialogue system is presented, which relies on the cloud-based Language Understanding Intelligent Service (LUIS) from Microsoft in order to recognize automatically the intention of a user from an utterance. For the evaluation of the cloud-based approach, the LUIS-based system is tested against a conservative hand-crafted grammar-based system by conducting an online study, with regard to the degree of the complexity of the user input. The main focus of the evaluation is put on system performance and user experience. For comparison of the different approaches, a mixed-initiative dialogue is designed for each system. Fassung June 8, 2017
CD8+ and CD8− NK cells and immune checkpoint networks in peripheral blood during healthy pregnancy
Creators: name: Meggyes, Matyas
name: Nagy, David U.
name: Mezosi, Livia
name: Polgar, Beata
name: Szereday, Laszlo
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2025
Subjects: subject: 610

description: Pregnancy involves significant immunological changes to support fetal development while protecting the mother from infections. A growing body of evidence supports the importance of immune checkpoint pathways, especially at the maternal–fetal interface, although limited information is available about the peripheral expression of these molecules by CD8+ and CD8− NK cell subsets during the trimesters of pregnancy. Understanding the dynamics of these immune cells and their checkpoint pathways is crucial for elucidating their roles in pregnancy maintenance and potential complications. This study aims to investigate the peripheral expression and functional characteristics of CD8+ and CD8− NK cell subsets throughout pregnancy, providing insights into their contributions to maternal and fetal health. A total of 34 healthy women were enrolled from the first, 30 from the second and 40 from the third trimester of pregnancy. At the same time, 35 healthy age-matched non-pregnant women formed the control group. From peripheral blood, mononuclear cells were separated and stored at −80 °C. CD8+ and CD8− NK cell subsets were analyzed from freshly thawed samples, and surface and intracellular staining was performed using flow cytometric analyses. The proportions of CD56+ NK cells in peripheral blood were similar across groups. While CD8− NKdim cells increased significantly in all trimesters compared to non-pregnant controls, CD8+ NKdim cells showed no significant changes. CD8− NKbright cells had higher frequencies throughout pregnancy, whereas CD8+ NKbright cells significantly increased only in the first and second trimesters. The expression levels of immune checkpoint molecules, such as PD-1 and PD-L1, and cytotoxic-activity-related molecules were stable, with notable perforin and granzyme B increases in CD8− NKbright cells throughout pregnancy. Our study shows that peripheral NK cell populations, especially CD8− subsets, are predominant during pregnancy. This shift suggests a crucial role for CD8− NK cells in balancing maternal immune tolerance and surveillance. The stable expression of immune checkpoint molecules indicates that other regulatory mechanisms may be at work. These findings enhance our understanding of peripheral immune dynamics in pregnancy and suggest that targeting CD8− NKbright cell functions could help manage pregnancy-related immune complications. This research elucidates the stable distribution and functional characteristics of peripheral NK cells during pregnancy, with CD8− subsets being more prevalent. The increased activity of CD8− NKbright cells suggests their critical role in maintaining immune surveillance. Our findings provide a basis for future studies to uncover the mechanisms regulating NK cell function in pregnancy, potentially leading to new treatments for immune-related pregnancy complications.
Kernel Machine and Distributed Lag Models for Assessing Windows of Susceptibility to Environmental Mixtures in Children's Health Studies
Creators: name: Wilson, Ander
name: Hsu, Hsiao-Hsien Leon
name: Chiu, Yueh-Hsiu Mathilda
name: Wright, Robert O.
name: Wright, Rosalind J.
name: Coull, Brent A.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Applications (stat.AP)
subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: Exposures to environmental chemicals during gestation can alter health status later in life. Most studies of maternal exposure to chemicals during pregnancy have focused on a single chemical exposure observed at high temporal resolution. Recent research has turned to focus on exposure to mixtures of multiple chemicals, generally observed at a single time point. We consider statistical methods for analyzing data on chemical mixtures that are observed at a high temporal resolution. As motivation, we analyze the association between exposure to four ambient air pollutants observed weekly throughout gestation and birth weight in a Boston-area prospective birth cohort. To explore patterns in the data, we first apply methods for analyzing data on (1) a single chemical observed at high temporal resolution, and (2) a mixture measured at a single point in time. We highlight the shortcomings of these approaches for temporally-resolved data on exposure to chemical mixtures. Second, we propose a novel method, a Bayesian kernel machine regression distributed lag model (BKMR-DLM), that simultaneously accounts for nonlinear associations and interactions among time-varying measures of exposure to mixtures. BKMR-DLM uses a functional weight for each exposure that parameterizes the window of susceptibility corresponding to that exposure within a kernel machine framework that captures non-linear and interaction effects of the multivariate exposure on the outcome. In a simulation study, we show that the proposed method can better estimate the exposure-response function and, in high signal settings, can identify critical windows in time during which exposure has an increased association with the outcome. Applying the proposed method to the Boston birth cohort data, we find evidence of a negative association between organic carbon and birth weight and that nitrate modifies the organic carbon, ...
Additional file 1 of Factors influencing necrotizing enterocolitis in premature infants in China: a systematic review and meta-analysis
Creators: name: Zhao, Shuliang
name: Jiang, Huimin
name: Miao, Yiqun
name: Liu, Wenwen
name: Li, Yanan
name: Liu, Hui
name: Wang, Aihua
name: Cui, Xinghui
name: Zhang, Yuanyuan
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Science Policy

description: Additional file 1.
Online Supplementary Data: Deep-time biodiversity patterns and the dinosaurian fossil record of the Late Cretaceous Western Interior, USA
Creators: name: Maidment, Susannah
Publisher: name: Zenodo
Year: 2021

description: In order for palaeontological data to be informative to ecologists seeking to understand the causes of today's diversity patterns, palaeontologists must demonstrate that actual biodiversity patterns are preserved in our reconstructions of past ecosystems. During the Late Cretaceous, North America was divided into two landmasses, Laramidia and Appalachia. Previous work has suggested strong faunal provinciality on Laramidia at this time, but these arguments are almost entirely qualitative. We quantitatively investigated faunal provinciality in ceratopsid and hadrosaurid dinosaurs using a biogeographic network approach and investigated sampling biases by examining correlations between dinosaur occurrences and collections. We carried out a model-fitting approach using generalized least-squares regression to investigate the sources of sampling bias we identified. We find that while the raw data strongly support faunal provinciality, this result is driven by sampling bias. The data quality of ceratopsids and hadrosaurids is currently too poor to enable fair tests of provincialism, even in this intensively sampled region, which probably represents the best-known Late Cretaceous terrestrial ecosystem on Earth. To accurately reconstruct biodiversity patterns in deep time, future work should focus on smaller scale, higher resolution case studies in which the effects of sampling bias can be better controlled.
A Dataset of EMF Models from Eclipse Projects
Creators: name: (:Unkn) Unknown
Publisher: name: Universität Ulm
Year: 2018
Subjects: subject: model driven software engineering
subject: model mining
subject: model evolution
subject: EMF
subject: DDC 004 / Data processing & computer science
subject: Data mining
subject: Model-driven software architecture
subject: Model-integrated computing
subject: Eclipse (Electronic resource)
subject: Computer software; Development
subject: Data Mining
subject: Software Engineering

description: Models are key artefacts in Model-driven software engineering. Data sets of models from practice are highly valuable as input for different modelling research areas, e.g., performance benchmarks for modelling tools and analysing model transformations, as well as in empirical research, e.g., understanding how models are designed and evolve over time. Unfortunately, there is a lack of data sets containing models, their meta models, and their evolution history. We present such a data set and describe our data collection method. The Eclipse modeling framework (EMF) is the major framework for developing and using EMF models providing a rich ecosystem developing many models and meta models. Thus, we mined meta models and their instances from git repositories associated with Eclipse projects (https://www.eclipse.org/projects/, accessed 2018-05-25), including their version history. Our data set was created on 2018-05-25 and contains 31799 models of which 4732 are meta models with a total of 101267 versions. These were mined from 247 repositories belonging to 130 projects hosted on Eclipse Projects.