Bisphenol S modulates concentrations of bisphenol A and oestradiol in female and male mice
Creators: name: Pollock, Tyler
name: Greville, Lucas J.
name: Weaver, Rachel E.
name: Radenovic, Marija
name: DeCatanzaro, Denys
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: FOS: Health sciences

description: Concern over endocrine-disrupting actions of bisphenol A (BPA) has prompted some manufacturers to remove it from consumer products. Among the chemical replacements in “BPA-free” products are other bisphenol analogues, such as bisphenol S (BPS). Given evidence that BPA and BPS possess similar oestrogenic activity, their capacity to interact and disrupt oestrogen homeostasis should be examined.We investigated whether BPS can modulate concentrations of <sup>14</sup>C-BPA, exogenous <sup>3</sup>H-oestradiol (E2), or natural E2. CF-1 mice were each given a single subcutaneous injection of oil containing 0 (vehicle), 1, 3, or 9 mg BPS, then given a dietary supplement containing either 50 μg/kg <sup>14</sup>C-BPA or 5 μCi (14.5 ng) <sup>3</sup>H-E2. BPS treatment elevated <sup>14</sup>C-BPA concentrations in blood serum and certain reproductive organs of both sexes, but reduced <sup>3</sup>H-E2 concentrations in blood serum of females. In another experiment, natural E2 was measured in urine 2–12 h after injection of 0 (vehicle), 1, or 3 mg BPS. BPS reduced E2 concentrations at 10 h after injection in both sexes.These results are consistent with evidence that BPS and BPA compete for access to metabolic enzymes, and that BPS can disrupt oestrogen homeostasis. These findings demonstrate the importance of considering multiple toxicants when determining regulatory exposure limits. Concern over endocrine-disrupting actions of bisphenol A (BPA) has prompted some manufacturers to remove it from consumer products. Among the chemical replacements in “BPA-free” products are other bisphenol analogues, such as bisphenol S (BPS). Given evidence that BPA and BPS possess similar oestrogenic activity, their capacity to interact and disrupt oestrogen homeostasis should be examined. We investigated whether BPS can modulate concentrations of <sup>14</sup>C-BPA, exogenous <sup>3</sup>H-oestradiol (E2), or natural E2. CF-1 mice were each given a single subcutaneous injection of oil containing 0 (vehicle), 1, 3, or 9 mg BPS, then given a dietary supplement containing either 50 μg/kg <sup>14</sup>C-BPA or 5 μCi (14.5 ng) <sup>3</sup>H-E2. BPS treatment elevated <sup>14</sup>C-BPA concentrations in blood serum and certain reproductive organs of both sexes, but reduced <sup>3</sup>H-E2 concentrations in blood serum of females. In another experiment, natural E2 was measured in urine 2–12 h after injection of 0 (vehicle), 1, or 3 mg BPS. BPS reduced E2 concentrations at 10 h after injection in both sexes. These results are consistent with evidence that BPS and BPA compete for access to metabolic enzymes, and that BPS can disrupt oestrogen homeostasis. These findings demonstrate the importance of considering multiple toxicants when determining regulatory exposure limits.