cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Hawking radiation and black hole spectroscopy in Horava-Lifshitz gravity
Creators: name: Majhi, Bibhas Ranjan
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Hawking radiation from the black hole in Horava-Lifshitz gravity is discussed by a reformulation of the tunneling method given in \cite{Banerjee:2008sn}. Using a density matrix technique the radiation spectrum is derived which is identical to that of a perfect black body. The temperature obtained here is proportional to the surface gravity of the black hole as occurs in usual Einstein gravity. The entropy is also derived by using the first law of black hole thermodynamics. Finally, the spectrum of entropy/area is obtained. The latter result is also discussed from the viewpoint of quasi-normal modes. Both methods lead to an equispaced entropy spectrum, although the value of the spacing is not the same. On the other hand, since the entropy is not proportional to the horizon area of the black hole, the area spectrum is not equidistant, a finding which also holds for the Einstein-Gauss-Bonnet theory.
description: Latex, 12 pages, no figure, paper shortened, basic results unchanged, to appear in Phys. Lett. B
Antibacterial cleaning products and drug resistance
Creators: name: Della-Latta, P.
name: Larson, E.
name: Aiello, A.E.
name: Lin, S.X.
name: Levy, S.B.
name: Marshall, B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: We examined whether household use of antibacterial cleaning and hygiene products is an emerging risk factor for carriage of antimicrobial drug-resistant bacteria on hands of household members. Households (N = 224) were randomized to use of antibacterial or nonantibacterial cleaning and hygiene products for 1 year. Logistic regression was used to assess the influence of antibacterial product use in homes. Antibacterial product use did not lead to a significant increase in antimicrobial drug resistance after 1 year (odds ratio 1.33, 95% confidence interval 0.74-2.41), nor did it have an effect on bacterial susceptibility to triclosan. However, more extensive and longer term use of triclosan might provide a suitable environment for emergence of resistant species. Further research on this issue is needed.
Temporary Lumbar Subcutaneous Cerebrospinal Fluid Shunt Placement in Pediatric Patient: a Technical Note
Creators: name: Zeenat Qureshi Stroke Institutes
Publisher: name: Zenodo
Year: 2023

description: Background—We report the technical aspects of lumbar subcutaneous cerebrospinal fluid (CSF) shuntfor temporary CSF drainage that may be an alternative strategy to lumbar catheter placement with externaldrainage system.Case Description—A 7 years and nine-month old boy with developmental delay, intermittent episodesof agitation, and combination of myoclonic and generalized tonic clonic seizures, associated with communicating hydrocephalus was evaluated. A temporary CSF drainage trial was contemplated to determinewhether a permanent CSF shunt would be beneficial. A temporary lumbar subcutaneous CSF shunt wasperformed to avoid catheter dislodgement or drainage system disruption due to child’s agitative behaviorand seizures. The catheter was inserted into the subarachnoid space at L3–L4 vertebral level and advancedapproximately 20 cm above site of insertion and approximately 4 cm was imbedded into the subcutaneoustissue. An ultrasound two days later demonstrated CSF collection in subcutaneous tissue measuring 3.48cm × 0.84 cm surrounding the catheter tip. The patient’s parents reported improvement in clinical symptoms after four days of CSF drainage.Conclusions—Lumbar subcutaneous CSF shunt may be used for temporary CSF drainage for diagnosticpurposes without the need for in patient admission and monitoring required for standard lumbar catheterwith external CSF drainage system.
title: Speeches by Secretary of Transportation Federico Pena: June-December 1996
Creators: name: Pena, Federico
name: United States Department of Transportation
Publisher: name: United States Department of Transportation
publisherIdentifier: https://ror.org/02xfw2e90
publisherIdentifierScheme: ROR
Year: 1996
Subjects: classificationCode: https://trt.trb.org/term/87904
subject: Transportation
classificationCode: https://trt.trb.org/term/89768
subject: Transportation planning
classificationCode: https://trt.trb.org/term/88891
subject: Transportation policy
classificationCode: https://trt.trb.org/term/90595
subject: Transportation safety
classificationCode: https://trt.trb.org/term/91422
subject: Economic and social factors
classificationCode: https://trt.trb.org/term/92116
subject: Federal government
classificationCode: https://trt.trb.org/term/92130
subject: Transportation departments

description: One zipped folder containing digitized PDFs. See the Secretary of Transportation Speeches Collection's finding aid at: https://ntl.as.atlas-sys.com/repositories/2/resources/4
description: Speeches by Secretary of Transportation Federico Pena from June 1996 through December 1996.
'Wandering stars' : the impact of British evangelists in Australia, 1870s-1900
Creators: name: Wilson, EK
Publisher: name: University Of Tasmania
Year: 2023

description: From the late 1870s to the early twentieth century, there was a steady stream of international speakers from Britain who travelled what was almost an evangelical circuit in south-eastern Australia. The argument of this thesis is that their impact has been overlooked or underplayed, and, while it was variable, it was nonetheless noticeable in various ways, both inside and outside the church community. Using mainly newspaper reports from a wide range of religious and secular newspapers, including reports sent back to England, but also biographies and contemporary documents where available, Part 1 of the thesis examines the revivalist networks which supported these evangelists, and the milieu into which they came. Using a biographical approach, each evangelist's career and personality is briefly considered, with special reference to his or her time in Australia. This part of the thesis brings together information which in many cases has been scattered, obscure, or unnoticed. The thesis then examines in detail the style and content of these evangelistic meetings, the impact of Sankey's gospel songs which these meetings introduced into Australia, the influence of three of the speakers on social issues such as prostitution, and the outcomes of these missions. The final chapter looks at both positive and negative expectations of evangelistic meetings, and at the perceived outcomes. The thesis argues that the short-term impact was probably the greatest, in terms of attendance and publicity. The meetings were almost always crowded, and newspaper reports, both secular and religious, were far more detailed and numerous than was expected at the beginning of the research. In the longer-term, however, assessment of the impact is more complex. It seems likely that most of the 'conversions' were from those who were nominal believers already, or fringe members of churches. The influence of the meetings was greatest in the denominations which supported them, as might be expected. The thesis argues that the long-term impact of these meetings and their 'stars' can be observed in the maintenance of church membership numbers, and the growth of some denominations, in the pervasive influence of 'Sankey's' gospel songs in both Christian and secular circles, in their contribution to the emergent campaigns for temperance and social purity, in the large increase of overseas missions recruits in the 1890s, and in the Christian conferences and conventions which promoted unity and holiness.
Model with Possible Fields Generated by Higher Dimensional Superconducting Cosmic Strings
Creators: name: Roy, Aaron J.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this paper we investigate the theory behind the results in [11]. In [11] we calculated the magnetic dipole moment of the muon and the electric dipole moments of the muon, electron and the neutron (in a simple quark model) to first order in loop corrections in both S$_1$ and S$_1 \backslash \, \boldsymbol{Z}_2$. In these calculations in [11] we investigated the effect of fields possibly generated by higher dimensional superconducting cosmic strings [12] that interact with the charged fields on the manifold. In comparing the results in [11] with standard model precision tests for the electric and magnetic dipole moments of the various fermions in the model, we were able to obtain upper limits on the compactification size as well as an upper limit for the new $b$ parameter. This new model has several important phenomenological implications. One of these is a theoretical phenomenon that is a source for parity violation in QED processes. In this paper we will be presenting the theory of the model in the compactification $M_4 \, \bigotimes$ S$_1 \backslash \, \boldsymbol{Z}_2$ (orbifold geometry). The theory predicts nontrivial couplings of the Higgs and lepton fields to the SU(2) gauge bosons, these differ from the standard model couplings. The theory also expounds upon the standard model results for the masses of the charged fields in the model and has other significant physical implications. The model is rooted in the notion that very light charged particles traveling next to superconducting cosmic strings [12] at distances on the order of the compactification size of the extra dimensional space, could generate currents that intern can create magnetic fields that interact with the particle fields on the UED manifold. Please see section V of [11] for a more detailed discussion of this.
Additional file 3 of CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in Huntington’s disease
Creators: name: Yu, Dahyun
name: Zarate, Nicole
name: White, Angel
name: Coates, De’jah
name: Tsai, Wei
name: Nanclares, Carmen
name: Cuccu, Francesco
name: Yue, Johnny S.
name: Brown, Taylor G.
name: Mansky, Rachel H.
name: Jiang, Kevin
name: Kim, Hyuck
name: Nichols-Meade, Tessa
name: Larson, Sarah N.
name: Gundry, Katherine
name: Zhang, Ying
name: Tomas-Zapico, Cristina
name: Lucas, Jose J.
name: Benneyworth, Michael
name: Öz, Gülin
name: Cvetanovic, Marija
name: Araque, Alfonso
name: Gomez-Pastor, Rocio
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3. Genetic deletion of CK2α’ does not ameliorate anxiety-like behaviors or locomotor asymmetry of zQ175 HD at 12 months of age. a-e, Gross motor performance, exploratory behavior, and anxiety-like behavior were assessed during 30 mins in an open field test. a, distance traveled, b, time spent at the center of the field, c, average locomotion velocity and d, time in the outer/inner zone of the field between zQ175 and zQ175:CK2α’ (+/-). e, Representative tracing images show the total distance traveled by the subject. f, Parameters of the spontaneous motor activity (number of rears) evaluated by a cylinder test. Error bars denote mean ± SEM, values were analyzed by two-way ANOVA with Sidak’s post-hoc test. n.s = not significant.
Viscosities of phase-separated glasses
Creators: name: Bernheim, Philippe
Publisher: name: University of British Columbia
Year: 2011

description: The effects of heat treatments on viscosity were analysed for three types of glasses. "Pyrex" glass could be approximated to a Newtonian liquid in the range of temperature 470 to 590°C. The activation energy for viscous flow varied from 65 to 85 kcal/mole according to the previous thermal history. All glasses exhibited phase separation to different degrees according to the heat treatments to which they had been submitted. Phase separation and different degrees of devitrification could account for the variation in viscosity which have been encountered. Several mathematical expressions were tested in an attempt to correlate viscosity change with time. The best fit was obtained with a relationship of the type n = (a + bt)[superscript]c where c varied in the range 0.2 to 0.5. In the case of a ternary borosilicate glass, the value was found to be 0.5. This may suggest that phase separation is a diffusion controlled process.
Medication Reconciliation at Nakhon Ratchasima Rajanagarindra Psychiatric Hospital
Creators: name: Kanita Puntakul
Publisher: name: Faculty of Pharmaceutical Sciences KKU MSU UBU
Year: 2012
Subjects: medication error, medication reconciliation, medication discrepancy

description: Isan Journal ofPharmaceutical Sciences, 8, 2, 27-40
Maximum-Likelihood Sequence Detector for Dynamic Mode High Density Probe Storage
Creators: name: Kumar, Naveen
name: Agarwal, Pranav
name: Ramamoorthy, Aditya
name: Salapaka, Murti
Publisher: name: arXiv
Year: 2009
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: There is an increasing need for high density data storage devices driven by the increased demand of consumer electronics. In this work, we consider a data storage system that operates by encoding information as topographic profiles on a polymer medium. A cantilever probe with a sharp tip (few nm radius) is used to create and sense the presence of topographic profiles, resulting in a density of few Tb per in.2. The prevalent mode of using the cantilever probe is the static mode that is harsh on the probe and the media. In this article, the high quality factor dynamic mode operation, that is less harsh on the media and the probe, is analyzed. The read operation is modeled as a communication channel which incorporates system memory due to inter-symbol interference and the cantilever state. We demonstrate an appropriate level of abstraction of this complex nanoscale system that obviates the need for an involved physical model. Next, a solution to the maximum likelihood sequence detection problem based on the Viterbi algorithm is devised. Experimental and simulation results demonstrate that the performance of this detector is several orders of magnitude better than the performance of other existing schemes.
description: This paper is published in IEEE Trans. on communication
title: Speeches by Secretary of Transportation Andrew H. Card, Jr.: March-June 1992
Creators: name: Card, Andrew H.  1947-
name: United States Department of Transportation
Publisher: name: United States Department of Transportation
publisherIdentifier: https://ror.org/02xfw2e90
publisherIdentifierScheme: ROR
Year: 1992
Subjects: classificationCode: https://trt.trb.org/term/87904
subject: Transportation
classificationCode: https://trt.trb.org/term/88891
subject: Transportation policy
classificationCode: https://trt.trb.org/term/89768
subject: Transportation planning
classificationCode: https://trt.trb.org/term/90595
subject: Transportation safety
classificationCode: https://trt.trb.org/term/91422
subject: Economic and social factors
classificationCode: https://trt.trb.org/term/92116
subject: Federal government
classificationCode: https://trt.trb.org/term/92130
subject: Transportation departments

description: One zipped folder containing PDFs of digitized speeches. See the Secretary of Transportation Speeches Collection's finding aid at: https://ntl.as.atlas-sys.com/repositories/2/resources/4
description: Speeches by Secretary of Transportation Andrew H. Card, Jr. from March 1992 through June 1992.
ANÁLISIS DE LAS POLÍTICAS Y NORMATIVAS EN ECONOMÍA CIRCULAR EN EL PERÚ
Creators: name: Neyra, Paulo César Delgado
Publisher: name: Zenodo
Year: 2020
Subjects: economía circular
desarrollo sostenible
derecho ambiental
políticas ambientales
políticas públicas
gestión de residuos

description: Este trabajo además de analizar doctrinariamente los aspectos generales de la economía circular, tales como sus características, elementos, principios, fuentes, beneficios, entre otros aspectos; aborda el modo en que las política y normas de economía circular deben ser formuladas, estudiando las etapas necesarias para su emisión (aspectos iniciales, evaluación del metabolismo de los sectores económicos, definición de la estrategia y su ejecución), así como la información necesaria para ello. Asimismo, efectúa un análisis comparado de las políticas y normativas de economía circular de la Unión Europea, España, Colombia y Perú, estudiando cada una de sus acciones, en función a su tipo, barreras a superar y ámbito de aplicación. Finalmente, propone alternativas de solución a los problemas identificados en la estrategia peruana de economía circular, abordando aspectos como la necesidad de su aplicación a nivel nacional, la falta de objetivos e indicadores y la importancia de establecer una gobernanza adecuada.
title: Region One Civil Aeronautics Administration Monthly Digest for July-August, 1957
title: Civil Aeronautics Administration First Region Monthly Digest for July-August, 1957
titleType: AlternativeTitle
Creators: name: United States Department of Commerce: Civil Aeronautics Administration
Publisher: name: United States Department of Transportation
publisherIdentifier: https://ror.org/02xfw2e90
publisherIdentifierScheme: ROR
Year: 1957
Subjects: classificationCode: https://trt.trb.org/term/92062
subject: Aviation
classificationCode: https://trt.trb.org/term/91623
subject: Personnel
classificationCode: https://trt.trb.org/term/88724
subject: Government funding
classificationCode: https://trt.trb.org/term/91634
subject: Government employees
classificationCode: https://trt.trb.org/term/88618
subject: Awards
classificationCode: https://trt.trb.org/term/90595
subject: Transportation safety
classificationCode: https://trt.trb.org/term/90596
subject: Aviation safety

description: See the Civil Aeronautics Administration Region One News and Monthly Digests finding aid at: https://ntl.as.atlas-sys.com/repositories/2/resources/46
description: Updates on activities and projects from each division (Airports; Air Carrier Safety; Air Traffic Control; Air Navigation Facilities; Aircraft Engineering; and General Safety) of Region One (the Eastern Region) Civil Aeronautics Administration employees.
A self-regulating and patch subdivided population
Creators: name: Belhadji, Lamia
name: Bertacchi, Daniela
name: Zucca, Fabio
Publisher: name: arXiv
Year: 2008
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60K35

description: We consider an interacting particle process on a graph which, from a macroscopic point of view, looks like $\Z^d$ and, at a microscopic level, is a complete graph of degree $N$ (called a patch). There are two birth rates: an inter-patch one $λ$ and an intra-patch one $ϕ$. Once a site is occupied, there is no breeding from outside the patch and the probability $c(i)$ of success of an intra-patch breeding decreases with the size $i$ of the population in the site. We prove the existence of a critical value $λ_{cr}(ϕ, c, N)$ and a critical value $ϕ_{cr}(λ, c, N)$. We consider a sequence of processes generated by the families of control functions $\{c_i\}_{i \in \N}$ and degrees $\{N_i\}_{i \in \N}$; we prove, under mild assumptions, the existence of a critical value $i_{cr}$. Roughly speaking we show that, in the limit, these processes behave as the branching random walk on $\Z^d$ with external birth rate $λ$ and internal birth rate $ϕ$. Some examples of models that can be seen as particular cases are given.
description: 16 pages, fixed some minor misprints in the proof of Theorem 3.2
Chiral Zero Modes on Intersecting Heterotic 5-branes
Creators: name: Kimura, Tetsuji
name: Mizoguchi, Shun'ya
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We show that there exist two 27 and one 27bar of E6, net one chiral supermultiplet as zero modes localized on the intersecting 5-branes in the E8 x E8 heterotic string theory. A heterotic background is constructed by the standard embedding in the smeared solution, and the Dirac equation is solved explicitly on this background. It provides, after a compactification of some of the transverse dimensions, a Randall-Sundrum II like brane-world set-up in heterotic string theory.
description: 10 pages, 3 figures; (v3) title changed (v4) corrupted figures replaced (v5) references added
Medical Service Charges of Childhood Asthmatic Patients Admitted at Maharaj Nakorn Chiang Mai Hospital
Creators: name: Kanchanika Yodying
Publisher: name: Faculty of Pharmaceutical Sciences KKU MSU UBU
Year: 2012
Subjects: Pediatric patients, Cost, Asthma

description: Isan Journal ofPharmaceutical Sciences, 8, 2, 53-59
Impact of Galactic polarized emission on B-mode detection at low multipoles
Creators: name: Efstathiou, George
name: Gratton, Steven
name: Paci, Francesco
Publisher: name: arXiv
Year: 2009
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We use a model of polarized Galactic emission developed by the the Planck collaboration to assess the impact of foregrounds on B-mode detection at low multipoles. Our main interest is to applications of noisy polarization data and in particular to assessing the feasibility of B-mode detection by Planck. This limits the complexity of foreground subtraction techniques that can be applied to the data. We analyze internal linear combination techniques and show that the offset caused by the dominant E-mode polarization pattern leads to a fundamental limit of r approximately 0.1 for the tensor-scalar ratio even in the absence of instrumental noise. We devise a simple, robust, template fitting technique using multi-frequency polarization maps. We show that template fitting using Planck data alone offers a feasible way of recovering primordial B-modes from dominant foreground contamination, even in the presence of noise on the data and templates. We implement and test a pixel-based scheme for computing the likelihood function of cosmological parameters at low multipoles that incorporates foreground subtraction of noisy data.
description: 20 pages, 10 figures
Field observations in an oxycline in relation to laboratory determinations of oxygen requirements in some species of marine zooplankton
Creators: name: Fish, Arthur Geoffrey
Publisher: name: University of British Columbia
Year: 2011

description: Preliminary investigations of Saanich Inlet, Vancouver Island, British Columbia, indicated that there was a stratification in the depth of occurrence, during daytime, of the euphausiid Euphausia pacifica and the amphipods Cyphocaris challengeri and Orchomenella pinguis. The presence of an oxycline and a gradient in the carbon dioxide concentration suggested that the stratification was associated with these environmental factors. A programme was conducted between July 1962 and June 1963 to determine whether the stratification was a persistent phenomenon and whether physical and chemical characteristics of the water were associated with the distribution of the organisms. Clarke-Bumpus plankton samplers were towed above, within, and below the oxycline on seven cruises. The survival of the species was measured above, within, and below the oxycline, for exposures of 1 to 12 hours for Euphausia pacifica and Cyphocaris challengeri and of 9 to 24 hours for Orchomenella pinguis, by lowering specimens in cylinders which were in communication with the environment. Laboratory experiments measured the oxygen consumption of the species when carbon dioxide produced by the organisms in experimental chambers accumulated and when it was absorbed. Stratification was a persistent phenomenon in which Euphausia pacifica occupied the upper position, Orchomenella pinguis the lower position and Cyphocaris challengeri an inter-mediate or upper position in the daytime aggregation of organisms. The position of the aggregation was not influenced by temperature or salinity, but was related to the concentration of oxygen, and carbon dioxide. The field experiments showed that Orchomenella pinguis could tolerate lower oxygen and higher carbon dioxide concentrations for much longer durations of exposure than could the other two species. The laboratory experiments indicated Orchomenella pinguis and Cyphocaris challengeri consumed less oxygen than Euphausia pacifica, but Cyphocaris challengeri was more susceptible to high concentrations of carbon dioxide than the other species. These facts offer partial explanations for the stratification of the species.
Additional file 8 of CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in Huntington’s disease
Creators: name: Yu, Dahyun
name: Zarate, Nicole
name: White, Angel
name: Coates, De’jah
name: Tsai, Wei
name: Nanclares, Carmen
name: Cuccu, Francesco
name: Yue, Johnny S.
name: Brown, Taylor G.
name: Mansky, Rachel H.
name: Jiang, Kevin
name: Kim, Hyuck
name: Nichols-Meade, Tessa
name: Larson, Sarah N.
name: Gundry, Katherine
name: Zhang, Ying
name: Tomas-Zapico, Cristina
name: Lucas, Jose J.
name: Benneyworth, Michael
name: Öz, Gülin
name: Cvetanovic, Marija
name: Araque, Alfonso
name: Gomez-Pastor, Rocio
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 8. RNA-Seq comparison between samples and with Langfelder et al., 2016 [49]. a, Kruskal-Wallis test of module expressions between zQ175 mice and WT mice. b IPA canonical pathway analysis of module genes for module “Red”. c, Cook’s distance (DESeq2), which is a measure of how much a single sample is influencing the fitted coefficients for a gene, for all tested samples (HET = CK2α’(+/-), KI = zQ175, KIHET = zQ175:CK2α’(+/-)). d, Network visualization of top 15% connected genes for module genes of module “Greenyellow”. The size of the circles was scaled by the absolute value of the mean log2-fold change between zQ175 and zQ175:CK2α’(+/-) mice. e, MA-plot of differential gene expression between HD (zQ175) and WT mice. f, Venn Diagram of differentially expressed genes between HD (zQ175) and WT mice in comparison to Langfelder 2016 data. g, MA-plot of differential gene expression between zQ175:CK2α’(+/-) and WT mice. h, Venn Diagram of differentially expressed genes between zQ175, WT, zQ175:CK2α’(+/-) and CK2α’(+/-) mice. i, Driver factors of gene expression variance (genotype and/or gender) for the DGEs identified between zQ175 and zQ175:CK2α’(+/-) were evaluated using R package variance Partition.
Implementing Reproducible Environmental Data Science with Open Science: Lessons from the 1st Climate Informatics Reproducibility Challenge
Creators: name: McDonald, Andrew
name: Coca-Castro, Alejandro
name: Fouilloux, Anne
name: Ricardo, Barros Lourenço
name: Hyde, Andrew
name: Rao, Yuhan (Douglas)
Publisher: name: Zenodo
Year: 2023

description: This presentation is given by Andrew McDonald, MRes + PhD Student in the AI4ER CDT at the University of Cambridge and British Antarctic Survey, to the AGU23 session.

The presentation shares insights from the 2023 Climate Informatics Reproducibility Challenge (CIRC23). The videos/animation of winning team is included.

More information about CIRC23 can be found on the website. 

For EDS book, please visit the Github project or website.
Factors Affecting Pharmacist Standard Performance in Community Hospitals, Public Health Inspection Region 6
Creators: name: Jaruwan Jullasat
Publisher: name: Faculty of Pharmaceutical Sciences KKU MSU UBU
Year: 2012
Subjects: Motivation, Pharmacist standard performance, Community hospital, Pharmacist

description: Isan Journal ofPharmaceutical Sciences, 8, 2, 60-75
Remarks on the instability of black Dp-branes
Creators: name: Lu, J. X.
name: Roy, Shibaji
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We show that for black D$p$-branes having charge $Q$ and Hawking temperature $T$, the product $QT^{7-p}$ is bounded from above for $p\leq 5$ and is unbounded for $p=6$. While the maximum occurs at some finite value of a parameter for $p \leq 4$, it occurs at infinity of the parameter for $p=5$. As a consequence, for fixed charge, there are two black D$p$-branes (for $p\leq 4$) at any given temperature less than its maximum value, and when the temperature is maximum there is one black D$p$-brane. For $p=5$, there is only one black D5-brane at a given temperature less than its maximum value, whereas, for $p=6$, since there is no bound for the temperature, there is always a black D6-brane solution at a given temperature. Of the two black D$p$-branes (for $p\leq 4$), one is large which is shown to be thermodynamically unstable and the other is small which is stable. But for $p=5,6$, the black D$p$-branes are always thermodynamically unstable. The stable, small black D$p$-brane, however, under certain conditions, can become unstable quantum mechanically and decay either to a BPS D$p$-brane or to a Kaluza-Klein "bubble of nothing" through closed string tachyon condensation. The small D5, D6 branes, although classically unstable, have the same fate under similar conditions.
description: 12 pages, LaTeX, 1 figure, v2: minor clarifications added, v3: added free energy calculation, version to appear in Phys. Lett. B
D2 Dopamine Receptor G Protein-Biased Partial Agonists Based on Cariprazine
Creators: name: Pogorelov, V.M.
name: McCorvy, J.D.
name: Liu, J.
name: Jin, J.
name: Shen, Y.
name: Wetsel, W.C.
name: Roth, B.L.
name: Martini, M.L.
name: Rodriguiz, R.M.
name: Ward, K.M.
Publisher: name: American Chemical Society
Year: 2019

description: Functionally selective G protein-coupled receptor ligands are valuable tools for deciphering the roles of downstream signaling pathways that potentially contribute to therapeutic effects versus side effects. Recently, we discovered both Gi/o-biased and β-arrestin2-biased D2 receptor agonists based on the Food and Drug Administration (FDA)-approved drug aripiprazole. In this work, based on another FDA-approved drug, cariprazine, we conducted a structure-functional selectivity relationship study and discovered compound 38 (MS1768) as a potent partial agonist that selectively activates the Gi/o pathway over β-arrestin2. Unlike the dual D2R/D3R partial agonist cariprazine, compound 38 showed selective agonist activity for D2R over D3R. In fact, compound 38 exhibited potent antagonism of dopamine-stimulated β-arrestin2 recruitment. In our docking studies, compound 38 directly interacts with S1935.42 on TM5 but has no interactions with extracellular loop 2, which appears to be in contrast to the binding poses of D2R β-arrestin2-biased ligands. In in vivo studies, compound 38 showed high D2R receptor occupancy in mice and effectively inhibited phencyclidine-induced hyperlocomotion. © 2019 American Chemical Society.
title: Civil Aeronautics Administration Monthly Digest for November 1957
title: Civil Aeronautics Administration Region One Monthly Digest for November 1957
titleType: AlternativeTitle
Creators: name: United States Department of Commerce: Civil Aeronautics Administration
Publisher: name: United States Department of Transportation
publisherIdentifier: https://ror.org/02xfw2e90
publisherIdentifierScheme: ROR
Year: 1957
Subjects: classificationCode: https://trt.trb.org/term/92062
subject: Aviation
classificationCode: https://trt.trb.org/term/91623
subject: Personnel
classificationCode: https://trt.trb.org/term/88724
subject: Government funding
classificationCode: https://trt.trb.org/term/91634
subject: Government employees
classificationCode: https://trt.trb.org/term/90595
subject: Transportation safety
classificationCode: https://trt.trb.org/term/90596
subject: Aviation safety
classificationCode: https://trt.trb.org/term/88618
subject: Awards

description: See the Civil Aeronautics Administration Region One News and Monthly Digests finding aid at: https://ntl.as.atlas-sys.com/repositories/2/resources/46
description: Updates on activities and projects from each division (Airports; Air Carrier Safety; Air Traffic Control; Air Navigation Facilities; Aircraft Engineering; and General Safety) of Region One (the Eastern Region) Civil Aeronautics Administration employees.
title: Region One Civil Aeronautics Administration News and Monthly Digest: June 1958
Creators: name: United States Department of Commerce: Civil Aeronautics Administration
Publisher: name: United States Department of Transportation
publisherIdentifier: https://ror.org/02xfw2e90
publisherIdentifierScheme: ROR
Year: 1958
Subjects: classificationCode: https://trt.trb.org/term/92062
subject: Aviation
classificationCode: https://trt.trb.org/term/91623
subject: Personnel
classificationCode: https://trt.trb.org/term/91634
subject: Government employees
classificationCode: https://trt.trb.org/term/88724
subject: Government funding
classificationCode: https://trt.trb.org/term/88618
subject: Awards
classificationCode: https://trt.trb.org/term/90595
subject: Transportation safety
classificationCode: https://trt.trb.org/term/90596
subject: Aviation safety

description: See the Civil Aeronautics Administration Region One News and Monthly Digests finding aid at: https://ntl.as.atlas-sys.com/repositories/2/resources/46
description: Updates on activities and projects from each division (Airports; Air Carrier Safety; Air Traffic Control; Air Navigation Facilities; Aircraft Engineering; and General Safety) of Region One (the Eastern Region) Civil Aeronautics Administration employees.
Wohnen wie in den Ferien - Lebensstile, Mobilität und Wohnen im suburbanen Raum
Creators: name: Kasper, Birgit
Publisher: name: TU Dortmund
Year: 2003
Subjects: subject: Alltagsmobilität
subject: leitfadengestütztes Interview
subject: Siedlungsstruktur
subject: Wohnstandortwahl
subject: Lebensstil
subject: Suburbanisierung
subject: Suburbaner Raum
subject: 710
subject: Mobilität
subject: Suburbaner Raum
subject: Suburbanisierung
subject: Lebensstil
subject: Wohnen
subject: Siedlungsstruktur

description: Arbeitspapiere des Fachgebiets Verkehrswesen und Verkehrsplanung;7
Defining Structure-Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine D1 Receptor Agonists
Creators: name: Yu, X.
name: Roth, B.L.
name: Liu, J.
name: Jin, J.
name: Caron, M.G.
name: McCorvy, J.D.
name: Huang, X.-P.
name: Urs, A.
name: Ray, C.
name: Martini, M.L.
name: Urs, N.
Publisher: name: American Chemical Society
Year: 2019

description: G protein-coupled receptors (GPCRs) are capable of downstream signaling through distinct noncanonical pathways such as β-arrestins in addition to the canonical G protein-dependent pathways. GPCR ligands that differentially activate the downstream signaling pathways are termed functionally selective or biased ligands. A class of novel non-catechol G protein-biased agonists of the dopamine D1 receptor (D1R) was recently disclosed. We conducted the first comprehensive structure-functional selectivity relationship study measuring GS and β-arrestin2 recruitment activities focused on four regions of this scaffold, resulting in over 50 analogs with diverse functional selectivity profiles. Some compounds became potent full agonists of β-arrestin2 recruitment, while others displayed enhanced GS bias compared to the starting compound. Pharmacokinetic testing of an analog with an altered functional selectivity profile demonstrated excellent blood-brain barrier penetration. This study provides novel tools for studying ligand bias at D1R and paves the way for developing the next generation of biased D1R ligands. Copyright © 2019 American Chemical Society.
The effects of domestic dogs (Canis familiaris) as a disturbance agent on the natural environment
Creators: name: Holderness-Roddam, B
Publisher: name: University Of Tasmania
Year: 2023

description: This study assesses the impact of domestic dogs on the natural environment. The principal issue investigated is that of disturbance and the consequences for native wildlife, particularly vertebrate species. In addition to the catastrophic effects of killing, maiming and orphaning of wildlife; disturbance can contribute to energetic loss through premature flight or reduced feed intake and reproductive disruption due to nest disturbance. Dogs have been implicated in disease transmission to native wildlife; with faecal contamination of waterways having potential negative affects for marine mammal health. Hybridisation with other canid species is also an issue of concern, as is expropriation of land for the production of food for pet dogs. The study commences with an overview of ecological disturbance. The literature review then assesses the role of domestic dogs in ecological disturbance, public attitudes towards compliance with dog management legislation and the remediation and mitigation of disturbance by dogs. Data obtained from the Resource Management and Conservation section of the Tasmanian Department of Department of Primary Industries, Parks, Water and Environment regarding native wildlife presenting for care was analysed in order to determine the principal reported causes of death and injury to native wildlife in Tasmania. These results were then compared with data from the Australian Wildlife Health Centre - Wildlife Hospital at Healesville Sanctuary in Victoria and the data submitted by Tasmanian veterinarians through a three month diary of wildlife presentations recorded by ten practices. The data is indicative of domestic dogs having a more deleterious effect than domestic cats on native wildlife in Tasmania; particularly in urban and suburban areas and on beaches.
Recurrent Transcortical Motor Aphasia—Another CNS Infectious Syndrome Associated with Herpes Virus Infection
Creators: name: Zeenat Qureshi Stroke Institutes
Publisher: name: Zenodo
Year: 2023

description: Herpes simplex encephalitis is an acute/subacute illness that causes both general and focal signs of cerebraldysfunction with fever, headache, and confusion as cardinal features. Recurrent herpes simplex meningitis,also known as Mollaret’s meningitis, is another manifestation of central nervous system herpetic infectionwith recurrent episodes of fever, headache, and nuchal rigidity associated with cerebrospinal fluid (CSF)evidence of active herpes simplex infection. Bell’s palsy is yet another manifestation of a herpes virusinfection in at least some reported cases documented by CSF analysis. We report a case of a 70-year-oldmale who presented with acute transcortical motor aphasia initiating a stroke work-up that was negative.Physical examination revealed genital vesicles, and the CSF was consistent with active herpes simplexinfection.
Harnessing ion-binding sites for GPCR pharmacology
Creators: name: Zaidi, S.A.
name: Zarzycka, B.
name: Katritch, V.
name: Roth, B.L.
Publisher: name: American Society for Pharmacology and Experimental Therapy
Year: 2019

description: Endogenous ions play important roles in the function and pharmacology of G-protein coupled receptors (GPCRs). Historically the evidence for ionic modulation ofGPCRfunction dates to 1973 with studies of opioid receptors, where it was demonstrated that physiologic concentrations of sodium allosterically attenuated agonist binding. This Na+-selective effect was distinct from effects of other monovalent and divalent cations, with the latter usually counteracting sodium’s negative allosteric modulation of binding. Since then, numerous studies documenting the effects of mono- and divalent ions on GPCR function have been published. While ions can act selectively and nonselectively at many sites in different receptors, the discovery of the conserved sodium ion site in class A GPCR structures in 2012 revealed the unique nature of Na+ site, which has emerged as a near-universal site for allosteric modulation of class A GPCR structure and function. In this review, we synthesize and highlight recent advances in the functional, biophysical, and structural characterization of ions bound to GPCRs. Taken together, these findings provide a molecular understanding of the unique roles of Na+ and other ions as GPCR allosteric modulators. Wewill also discuss how this knowledge can be applied to the redesign of receptors and ligand probes for desired functional and pharmacological profiles. © 2019, American Society for Pharmacology and Experimental Therapy. All rights reserved.
title: Region One Civil Aeronautics Administration News and Monthly Digest: September 1958
title: Region One News and Monthly Digest September 1958
titleType: AlternativeTitle
Creators: name: United States Department of Commerce: Civil Aeronautics Administration
Publisher: name: United States Department of Transportation
publisherIdentifier: https://ror.org/02xfw2e90
publisherIdentifierScheme: ROR
Year: 1958
Subjects: classificationCode: https://trt.trb.org/term/92062
subject: Aviation
classificationCode: https://trt.trb.org/term/91623
subject: Personnel
classificationCode: https://trt.trb.org/term/88724
subject: Government funding
classificationCode: https://trt.trb.org/term/91634
subject: Government employees
classificationCode: https://trt.trb.org/term/88618
subject: Awards
classificationCode: https://trt.trb.org/term/90595
subject: Transportation safety
classificationCode: https://trt.trb.org/term/90596
subject: Aviation safety

description: See the Civil Aeronautics Administration Region One News and Monthly Digests finding aid at: https://ntl.as.atlas-sys.com/repositories/2/resources/46
description: Updates on activities and projects from each division (Airports; Air Carrier Safety; Air Traffic Control; Air Navigation Facilities; Aircraft Engineering; and General Safety) of Region One (the Eastern Region) Civil Aeronautics Administration employees.
Erratum: VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells (Cell (2019) 178(3) (748–761.e17), (S0092867419306221), (10.1016/j.cell.2019.05.051))
Creators: name: White, K.
name: Olsen, R.H.J.
name: Roth, B.L.
name: Strachan, R.T.
name: Cockrell, A.S.
name: Lansu, K.
name: Wacker, D.
name: English, J.G.
name: Patel, M.
name: Singh, D.
Publisher: name: Cell Press
Year: 2019

description: (Cell 178, 748–761.e1–e17; July 25, 2019) In our recent article reporting a platform for directed evolution in mammalian cells, we inadvertently failed to cite a paper that also reports a method for evolving biomolecules in mammalian cells (Berman et al., 2018). We have corrected the online version of our paper to cite this work, and we apologize for the omission. © 2019 Elsevier Inc.
Mid-Infrared Variability from the Spitzer Deep, Wide-Field Survey
Creators: name: Kozlowski, Szymon
name: Kochanek, Christopher S.
name: Stern, Daniel
name: Ashby, Matthew L. N.
name: Assef, Roberto J.
name: Bock, J. J.
name: Borys, C.
name: Brand, K.
name: Brodwin, M.
name: Brown, M. J. I.
name: Cool, R.
name: Cooray, A.
name: Croft, S.
name: Dey, Arjun
name: Eisenhardt, P. R.
name: Gonzalez, A.
name: Gorjian, V.
name: Griffith, R.
name: Grogin, N.
name: Ivison, R.
name: Jacob, J.
name: Jannuzi, B. T.
name: Mainzer, A.
name: Moustakas, L.
name: Rottgering, H.
name: Seymour, N.
name: Smith, H. A.
name: Stanford, S. A.
name: Stauffer, J. R.
name: Sullivan, I. S.
name: van Breugel, W.
name: Willner, S. P.
name: Wright, E. L.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We use the multi-epoch, mid-infrared Spitzer Deep, Wide-Field Survey to investigate the variability of 474,179 objects in 8.1 deg^2 of the NDWFS Bootes field. We perform a Difference Image Analysis of the four available epochs between 2004 and 2008, focusing on the deeper 3.6 and 4.5 micron bands. We find that 1.1% of the studied sample meet our standard selection criteria for being classed as a variable source. We require that the 3.6 and 4.5 micron light-curves are strongly correlated (r>0.8) and that their joint variance exceeds that for all sources with the same magnitude by 2 sigma. We then examine the mid-IR colors of the variable sources and match them with X-ray sources from the XBootes survey, radio catalogs, 24 micron-selected AGN candidates, and spectroscopically identified AGNs from the AGN and Galaxy Evolution Survey (AGES). Based on their mid-IR colors, most of the variable sources are AGNs (76%), with smaller contributions from stars (11%), galaxies (6%), and unclassified objects. Most of the stellar, galaxy and unclassified sources are false positives. For our standard selection criteria, 11-12% of the mid-IR counterparts to X-ray sources, 24 micron-selected AGN candidates and spectroscopically identified AGNs show variability. Mid-IR AGN variability can be well described by a single power-law structure function with a power-law index of 0.5 at both 3.6 and 4.5 microns, and an amplitude of 0.1 mag on rest-frame time scales of 2 years. The variability amplitude is higher for shorter rest-frame wavelengths and lower luminosities. (Abridged)
description: preprint 38 pages, 10 figures, full catalogs available from http://data.spitzer.caltech.edu/popular/sdwfs/20100503_enhanced/catalogs/
Molecular pharmacology of metabotropic receptors targeted by neuropsychiatric drugs
Creators: name: Roth, B.L.
Publisher: name: Nature Publishing Group
Year: 2019

description: Metabotropic receptors are responsible for so-called ‘slow synaptic transmission’ and mediate the effects of hundreds of peptide and non-peptide neurotransmitters and neuromodulators. Over the past decade or so, a revolution in membrane-protein structural determination has clarified the molecular determinants responsible for the actions of these receptors. This Review focuses on the G protein–coupled receptors (GPCRs) that are targets of neuropsychiatric drugs and shows how insights into the structure and function of these important synaptic proteins are accelerating understanding of their actions. Notably, elucidating the structure and function of GPCRs should enhance the structure-guided discovery of novel chemical tools with which to manipulate and understand these synaptic proteins.
The beautiful, durable and mundane : exploring notions of value in craft and design practice, in the context of sustainability
Creators: name: Skinner, RJ
Publisher: name: University Of Tasmania
Year: 2023

description: The project addresses issues of value and meaning in objects while at the same time considering more sustainable approaches to designing, making and consuming, through the reuse of already existing materials. By exploring concepts such as durability and ephemerality, the precious and the mundane, I have sought to show possibilities for reconciling the production of objects with reduced environmental effects of their production, use and disposal. This was an issue that tended to be neglected during the period of modernist design with its embracing of technology and the machine aesthetic. Since the 1960's with the emergence of designers and writers such as Victor Papanek and Buckminster Fuller there has been a growing concern to develop more sustainable approaches to design, and a broader consideration of meaning and engagement with objects. Some of the significant contemporary designers addressing these issues include Paolo Ulian, Hella Jongerius and Constantin and Laurene Boym. It is with reference to this field that I contextualise my practice. Through the research project I have recognised the importance of a local focus, in supporting more sustainable approaches and engagement with objects. In the process I have identified factors specific to designing with reuse materials, and have used them to guide the direction of the research. These include: material availability, perceived value of materials, time or cost required to achieve a high finish, design complexity and sophistication, and perceived value of the finished product. What has also emerged from the research is the importance of commercial considerations in designing for sustainability, as I believe economically viable objects contribute more than purely symbolic ones in influencing the perceptions and habits of designers and consumers. The project has shown that engagement with objects and sustainable approaches, when considered as integral to a design's development, can be mutually beneficial and lead to aesthetically sophisticated and highly valued objects.