Asthma Patients with Obesity have a Unique Phenotype: A subanalysis of the Turkish Adult Asthma Registry
Creators: name: Sozener, Zeynep Celebi
name: Oguzulgen, Ipek Kıvılcım
name: Ates, Funda Seher Ozalp
name: Baccioglu, Ayse
name: Barıs, Serap Argun
name: Ediger, Dane
name: Gunaydın, Fatma Esra
name: Sevinc, Can
name: Seker, Ummuhan
name: Kara, Bilge Yılmaz
name: Beyaz, Sengul
name: Mungan, Dilsad
name: Aydin, Omur
name: Gokmen, Derya
name: Buhari, Gozde Koycu
name: Gemicioglu, Bilun
name: Bulut, Ismet
name: Orcen, Cihan
name: Ozdemir, Secil Kepil
name: Keren, Metin
name: Damadoglu, Ebru
name: Yakut, Tugce
name: Kalpaklioglu, Ayse Fusun
name: Yalim, Sumeyra Alan
name: Yilmaz, Insu
name: Kalkan, Ilkay Koca
name: Uysal, Mehmet Atilla
name: Niksarlioglu, Elif Yelda Ozgun
name: Kalyoncu, Ali Fuat
name: Karakaya, Gul
name: Erbay, Muge
name: Nayci, Sibel
name: Tepetam, Fatma Merve
name: Gelincik, Asli Akkor
name: Dirol, Hulya
name: Goksel, Ozlem
name: Karaoglanoglu, Selen
name: Erkekol, Ferda Oner
name: Isik, Sacide Rana
name: Yildiz, Fusun
name: Yavuz, Yasemin
name: Karadogan, Dilek
name: Bozkurt, Nurgul
name: Basyigit, Ilknur
name: Ucar, Elif Yilmazel
name: Erdogan, Tuba
name: Polatli, Mehmet
name: Turk, Murat
name: Pur, Leyla
name: Katran, Zeynep Yegin
name: Sekibag, Yonca
name: Aykac, Enes Furkan
name: Gul, Ozcan
name: Cengiz, Ali
name: Akkurt, Bulent
name: Ozden, Seyma
name: Demir, Semra
name: Unal, Derya
name: Aslan, Ayse Feyza
name: Can, Ali
name: Gumusburun, Reyhan
name: Bogatekin, Gulhan
name: Akten, Hatice Serpil
name: Inan, Sinem
name: Erdinc, Munevver
name: Ogus, Aliye Candan
name: Kavas, Murat
name: Yulug, Demet Polat
name: Cakmak, Mehmet Erdem
name: Kaya, Saltuk Bugra
name: Alpagat, Gulistan
name: Ozgur, Eylem Sercan
name: Uzun, Oguz
name: Gulen, Sule Tas
name: Pekbak, Gulseren
name: Kizilirmak, Deniz
name: Havlucu, Yavuz
name: Donmez, Halil
name: Arslan, Bahar
name: Cetin, Gulden Pacaci
name: Soyyigit, Sadan
name: Karakis, Gulden Pasaoglu
name: Dursun, Adile Berna
name: Kendirlinan, Resat
name: Ozturk, Ayse Bilge
name: Simsek, Gokcen Omeroglu
name: Abadoglu, Oznur
name: Cerci, Pamir
name: Yucel, Taskin
name: Yorulmaz, Irfan
name: Tezcaner, Zahide Ciler
name: Tatar, Emel Cadalli
name: Suslu, Ahmet Emre
name: Ozer, Serdar
name: Dursun, Engin
name: Yorgancioglu, Arzu
name: Celik, Gulfem Elif
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Computational Biology

description: The obese-asthma phenotype has gradually increased in the last few years. We aimed to assess the differences between obese and non-obese patients with asthma. This research is a subanalysis of the Turkish Adult Asthma Registry (TAAR). Clinical presentation, disease control, severity, and demographics of obese and non-obese (lean, normal-weight, overweight) patients were compared. The obesity rate in TAAR was 32.2% (n = 619/1919; 18-83 years; 527 F/92 M). Patients with asthma and obesity had higher rates of childhood obesity, longer symptom duration, later onset of asthma, and more severe asthma. These patients were more likely to be female, older, less educated, and live in rural areas. Patients with obesity had more scheduled visits and emergency visits compared with non-obese patients, but similar asthma control, oral corticosteroid use, hospitalizations, intensive care unit admissions, and unscheduled visits. They also had a higher frequency of T2-high but lower frequency of possible T2-low phenotypes compared with normal-weight asthmatics. The risk of severe asthma in patients with obesity was 6.04 times higher for allergic than non-allergic patients and 3.58 times higher for the T2-high phenotype than for possible T2-low phenotypes. A one-unit increase in the asthma control test reduced the risk of severe asthma by 22%. A good definition of this phenotype is important to ensure that appropriate treatment strategies are implemented to achieve the control goal. We also believe that prevention of childhood obesity is an effective and pivotal strategy to achieve the goal of asthma control.