Additional file 1 of Radiopharmacokinetic modelling and radiation dose assessment of 223Ra used for treatment of metastatic castration-resistant prostate cancer
Creators: name: Höllriegl, Vera
name: Petoussi-Henss, Nina
name: Hürkamp, Kerstin
name: Ocampo Ramos, Juan Camilo
name: Li, Wei Bo
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology

description: Additional file 1: Supplement: Schematic representation of the biokinetic models and transfer rates of the 223Ra decay chain used in this work. Figure 1. Systemic model of radon (219Rn) as progeny of 223Ra, used in the present work for biokinetic and dosimetric modelling [1]. Exch, exchangeable; nonexch, non-exchangeable; ST0, ST1, ST2 represent soft tissue (ST) with fast, intermediate, and slow turnover, respectively. Table 1. Model parameters of 219Rn as radioactive progeny of 223Ra: transfer coefficients k (per day) are taken from [1, 2]. Figure 2. Systemic model of polonium (215Po and 211Po respectively) as progeny of 223Ra, used in the present work for biokinetic and dosimetric modelling [1]. Exch, exchangeable; nonexch, non-exchangeable; ST0, ST1, ST2 represent soft tissue (ST) with fast, intermediate, and slow turnover, respectively; RBC, red blood cells. Table 2. Model parameters of 215Po, and 211Po respectively, as radioactive progeny of 223Ra: transfer coefficients k (per day) are taken from [1, 2]. The transfer rate from compartment Plasma 1 to ST1 is lower than the value from [1] due to the additional compartment Cortical Marrow introduced for this work. Figure 3. Systemic model of lead (211Pb) as progeny of 223Ra used in the present work for biokinetic and dosimetric modelling [1]. Exch, exchangeable; nonexch, non-exchangeable; ST0, ST1, ST2 represent soft tissue (ST) with fast, intermediate, and slow turnover, respectively; RBC, red blood cells. Table 3. Model parameters of 211Pb as radioactive progeny of 223Ra: transfer coefficients k (per day) are taken from [1, 2]. Transfer rates from Plasma to all Other Soft Tissue compartments have lower values as those given at [1] due to the added compartments Trabecular Marrow, Cortical Marrow, Spleen, Skin, and Testes introduced for this work. Figure 4. Systemic model of bismuth (211Bi) as progeny of 223Ra used in the present work for biokinetic and dosimetric modelling [1]. Exch, exchangeable; nonexch, non-exchangeable; ST0, ST1, ST2 represent soft tissue (ST) with fast, intermediate, and slow turnover, respectively. Table 4. Model parameters of 211Bi as radioactive progeny of 223Ra: transfer coefficients k (per day) are taken from [1, 2]. The transfer rate from the compartment Plasma to ST1 is lower than the value given at [1] due to the added compartments Trabecular Marrow, Cortical Marrow, Spleen, Skin, and Testes. Figure 5. Systemic model of thallium (207TI) as progeny of 223Ra used in the present work for biokinetic and dosimetric modelling [1]. Exch, exchangeable; nonexch, non-exchangeable; ST0, ST1, ST2 represent soft tissue (ST) with fast, intermediate, and slow turnover, respectively; RBC, red blood cells. Table 5. Model parameters for 207TI as radioactive progeny of 223Ra: transfer coefficients k (per day) are taken from [1, 2] and from human alimentary tract model (HATM) [2]