cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Blueprint of the Common European Energy Data Space
Creators: name: Dognini, Alberto
name: Monti, Antonello
name: Kung, Antonio
name: Medela, Arturo
name: Joglekar, Charukeshi
name: Schaffer, Christoph
name: Stampatori, Daniele
name: Jimenez, Diana
name: Maqueda, Eric
name: Coelho, Fabio
name: Mancel, Florian
name: Sedighi, Foroogh
name: Hartner, Georg
name: Lipari, Gianluca
name: Valino, Javier
name: Jimeno Huarte, Joseba
name: Guitart, Laia
name: Schmitt, Laurent
name: Carreras, Leonardo
name: Karg, Ludwig
name: Kollenstart, Maarten
name: Santos Mugica, Maider
name: Kurz, Marc
name: Arles, Marion
name: Stroot, Markus
name: Baka, Maro
name: Galluccio, Martina
name: Bertoncini, Massimo
name: Fantino, Maurizio
name: Hödl, Oliver
name: Genest, Olivier
name: Bessa, Ricardo
name: Dornmair, Rita
name: Jimenez, Sonia
name: Tsitsanis, Tasos
name: Strasser, Thomas
name: Berkhout, Volker
Publisher: name: Zenodo
Year: 2024

description: This document addresses the concept of a Common European Energy Data Space (CEEDS), providing detailed approaches and recommendations for its real-world realization. In particular, the main objective of this blueprint is to guide on enhancing the existing data infrastructures, in the energy domain, towards the full embracement of data space solutions. Bridging this gap will empower the introduction of novel energy services, which will increase the efficiency and reliability of the energy systems while providing substantial benefits for every stakeholder. The key scope of this document is to present (i) a framework for new economically feasible business use cases and (ii) the general data space architecture that can enable them. This architecture aims to interconnect the existing data infrastructures, of legacy systems, with federated data spaces; at this scope, technical specifications have been included.
Il tenero abbraccio dei Gemelli
Creators: Fabrizio Villa
Publisher: name: Media Inaf
Year: 2024

Con il mese di marzo, e precisamente il giorno 20, inizia la primavera. La Luna, piena il 25, cercherà un po' di sollievo dalla luce del Sole passando nella penombra della Terra. L'eclissi parziale di penombra tuttavia non sarà visibile pienamente dall'Italia. Godiamo allora della Luna quando, il 18 del mese, si troverà nella costellazione dei Gemelli rischiarando il loro abbraccio. E se siete curiosi potete puntare con un binocolo la stella 55 Cancri – e sognare mondi alieni
Tutti detective di macchie solari con Zooniverse
Creators: Ufficio stampa Inaf
Publisher: name: Media Inaf
Year: 2024

Prende oggi il via sul portale web Zooniverse il progetto di citizen science “Sunspot Detectives”, curato dall'Istituto Max Planck per la ricerca sul Sistema solare, in Germania, e in Italia dall’Inaf. Gli scienziati chiedono aiuto ai cittadini per analizzare le osservazioni del Sole del 19esimo secolo realizzate da Angelo Secchi, con l’obiettivo di comprendere meglio la variabilità della nostra stella nel corso dei secoli
Additional file 8: Table S7. of Histone modifications facilitate the coexpression of bidirectional promoters in rice
Creators: name: Fang, Yuan
name: Wang, Lei
name: Ximeng Wang
name: You, Qi
name: Xiucai Pan
name: Xiao, Jin
name: Wang, Xiu-E
name: Yufeng Wu
name: Su, Zhen
name: Wenli Zhang
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology
subject: Computational Biology

description: Fold difference of intensity of histone marks and nucleosome occupancy between bidirectional genes and unidirectional genes. (PDF 246Â kb)
Sull’onda dell’Onda di Radcliffe
Creators: Rossella Spiga
Publisher: name: Media Inaf
Year: 2024

L'enorme struttura nella Via Lattea chiamata Onda di Radcliffe oscilla e si allontana dal centro della nostra galassia. Non è ancora chiaro come quest’onda estesa novemila anni luce – è la più grande struttura coerente di nubi di gas della Via Lattea – si sia formata e per quale motivo si stia muovendo. La scoperta è stata pubblicata su Nature
Additional file 5: Table S5. of Histone modifications facilitate the coexpression of bidirectional promoters in rice
Creators: name: Fang, Yuan
name: Wang, Lei
name: Ximeng Wang
name: You, Qi
name: Xiucai Pan
name: Xiao, Jin
name: Wang, Xiu-E
name: Yufeng Wu
name: Su, Zhen
name: Wenli Zhang
Publisher: name: Figshare
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology
subject: Computational Biology

description: Overrepresented motifs in BDPs response to drought stress (PDF 348Â kb)
Pheidole capensis Mayr, 1862, n. sp.
Creators: name: Mayr, G.
Publisher: name: Zenodo
Year: 1862
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Pheidole
Pheidole capensis

description: 4. P. capensis n. sp.
Soldat. Laenge: 5 mm. Rothbraun oder rothgelb, Fuehler und Beine heller, Kaurand der Mandibeln schwarz. Mandibeln sehr zerstreut punctirt, glaenzend. Vorderkopf fein laengsgestreift, Hinterkopf glatt und glaenzend. Thorax groesstentheils quer-, auch verworren gerunzelt. Pronotum mit zwei Hoeckern Metanotum mit an der Basis dicken, nicht langen und nicht fein zugespitzten Zaehnen. Erster Knoten oben schwach ausgerandet, der zweite beiderseits stumpfzaehnig, beide Knoten seicht gerunzelt. Hinterleib glatt und glaenzend.
[[worker]] Laenge: 2.5 mm Braeunlich rothgelb, glaenzend, Kopf dunkler, Tarsen blassgelb. Clypeus in der Mitte ziemlich glatt, seitlich laengsgestreift, Stirn glatt, in der Naehe der Stirnleisten mit feinen Laengsstreifen, Scheitel glatt, Wangen fein laengsgestreift. Pronotum auf der Scheibe glatt, vorne schwach quergestreift, seitlich schwach gerunzelt, Meso- und Metanotum fein netzmaschig. Knoten und Hinterleib glatt.
Cap der guten Hoffnung (Novara).
description: Published as part of Mayr, G., 1862, Myrmecologische Studien., pp. 649-776 in Verhandlungen der Zoologisch-Botanischen Gesellschaft in Wien 12 on pages 746-747
Blueprint of the Common European Energy Data Space
Creators: name: Dognini, Alberto
name: Monti, Antonello
name: Kung, Antonio
name: Medela, Arturo
name: Joglekar, Charukeshi
name: Schaffer, Christoph
name: Stampatori, Daniele
name: Jimenez, Diana
name: Maqueda, Eric
name: Coelho, Fabio
name: Mancel, Florian
name: Hartner, Georg
name: Lipari, Gianluca
name: Valino, Javier
name: Jimeno Huarte, Joseba
name: Guitart, Laia
name: Schmitt, Laurent
name: Karg, Ludwig
name: Kollenstart, Maarten
name: Santos Mugica, Maider
name: Kurz, Marc
name: Arles, Marion
name: Stroot, Markus
name: Baka, Maro
name: Galluccio, Martina
name: Bertoncini, Massimo
name: Fantino, Maurizio
name: Hödl, Oliver
name: Genest, Olivier
name: Bessa, Ricardo
name: Dornmair, Rita
name: Jimenez, Sonia
name: Tsitsanis, Tasos
name: Strasser, Thomas
name: Berkhout, Volker
Publisher: name: Zenodo
Year: 2024

description: This document addresses the concept of a Common European Energy Data Space (CEEDS), providing detailed approaches and recommendations for its real-world realization. In particular, the main objective of this blueprint is to guide on enhancing the existing data infrastructures, in the energy domain, towards the full embracement of data space solutions. Bridging this gap will empower the introduction of novel energy services, which will increase the efficiency and reliability of the energy systems while providing substantial benefits for every stakeholder. The key scope of this document is to present (i) a framework for new economically feasible business use cases and (ii) the general data space architecture that can enable them. This architecture aims to interconnect the existing data infrastructures, of legacy systems, with federated data spaces; at this scope, technical specifications have been included.
Viaggio nella formazione planetaria in 80 stelle
Creators: Redazione Eso
Publisher: name: Media Inaf
Year: 2024

Osservati con lo strumento Sphere del Vlt gli spettacolari dischi di formazione planetaria attorno a 86 giovani stelle in tre diverse regioni della nostra galassia: Taurus, Chamaeleon I e Orione. I risultati sono stati pubblicati oggi in tre articoli su Astronomy & Astrophysics, uno dei quali guidato da Antonio Garufi dell’Istituto nazionale di astrofisica
Additional file 3: Table S3. of Histone modifications facilitate the coexpression of bidirectional promoters in rice
Creators: name: Fang, Yuan
name: Wang, Lei
name: Ximeng Wang
name: You, Qi
name: Xiucai Pan
name: Xiao, Jin
name: Wang, Xiu-E
name: Yufeng Wu
name: Su, Zhen
name: Wenli Zhang
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Plant Biology

description: Summary of motifs identified in randomly selected 1000 UDPs, non-drought inducible BDPs and drought inducible UDPs. (PDF 514Â kb)
title: Опыт участия студенческого научного общества социологического факультета Самарского университета в научном семинаре «Форсайт труда и профессии будущего»
Creators: name: Бочаров, В. Ю.
name: Васькина, Ю. В.
Publisher: name: Реноме
Year: 2024

description: В течение 2023 г. было проведено достаточно большое количество научных мероприятий, посвященных анализу проблем занятости и трудовых отношений в современных российских условиях. В частности, рассматривались вопросы качества занятости наемных работников и самозанятых, возможность активизации трудового поведения наемного персонала и в целом перспективы цифровизации сферы наемного труда. Контекст таких дискуссий был обусловлен государственной стратегией формирования технологического и промышленного суверенитета России в условиях внешнеполитических вызовов и необходимостью развития трудового потенциала работников.
Additional file 9: Table S8. of Histone modifications facilitate the coexpression of bidirectional promoters in rice
Creators: name: Fang, Yuan
name: Wang, Lei
name: Ximeng Wang
name: You, Qi
name: Xiucai Pan
name: Xiao, Jin
name: Wang, Xiu-E
name: Yufeng Wu
name: Su, Zhen
name: Wenli Zhang
Publisher: name: Figshare
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Comparison between ChIP-seq and ChIP-qPCR assay in an individual BDP locus. (PDF 247Â kb)
Additional file 19: Figure S6. of RNA sequencing-based analysis of the spleen transcriptome following infectious bronchitis virus infection of chickens selected for different mannose-binding lectin serum concentrations
Creators: name: Hamzić, Edin
name: Kjærup, Rikke
name: Mach, Núria
name: Guilietta Minozzi
name: Strozzi, Francesco
name: Gualdi, Valentina
name: Williams, John
name: Chen, Jun
name: Wattrang, Eva
name: Buitenhuis, Bart
name: Juul-Madsen, Helle
name: Dalgaard, Tina
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Network representation of enriched GO Immune System terms of differentially expressed (DE) genes for comparison between infected birds at week 3. The GO Immune System terms were identified as nodes and linked based on their kappa score level (> = 0.4) and p-value
Совершенствование технологии получения энергосберегающей строительной керамики из местного сырья.
Creators: name: Erdashev Tayir Farxad ulı, Torebek Uzaqov
Publisher: name: Zenodo
Year: 2024

description: Аннотация: В данной статье говорится об энергоэффективности, энергосберегающих изоляционных материалах, современных строительных материалах и их рациональном использовании, совершенствовании технологии получения энергосберегающей строительной керамики из местного сырья.

 Ключевые слова: энергоэффективность, энергоресурсы, изоляционный материал, теплоизолятор, прозрачные конструкции, энергосберегающие материалы.
Misurata la gravità in un mondo (quasi) quantistico
Creators: Maura Sandri
Publisher: name: Media Inaf
Year: 2024

Avvalendosi di un sofisticato set-up strumentale che fa uso di sensori meccanici levitati di dimensioni mesoscopiche, gli scienziati sono riusciti a misurare una forza di attrazione gravitazionale molto debole, di appena 30 attonewton, su una minuscola particella di 0,43 milligrammi. Gli autori sostengono che la scoperta potrebbe aprire la strada alla teoria della gravità quantistica. Tutti i dettagli su Science Advances
Additional file 2: Figure S1. of RNA sequencing-based analysis of the spleen transcriptome following infectious bronchitis virus infection of chickens selected for different mannose-binding lectin serum concentrations
Creators: name: Hamzić, Edin
name: Kjærup, Rikke
name: Mach, Núria
name: Guilietta Minozzi
name: Strozzi, Francesco
name: Gualdi, Valentina
name: Williams, John
name: Chen, Jun
name: Wattrang, Eva
name: Buitenhuis, Bart
name: Juul-Madsen, Helle
name: Dalgaard, Tina
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biophysics
subject: Cell Biology
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Multidimensional scaling (MDS) plot created using expression profiles of all normalized genes. Four MDS plots were created using the normalized gene count data set. The purpose of MDS plot is to provide a visual representation of the pattern of proximities (similarities or distances) among the set of studied birds. Plots are labeled by eight comparison groups and three different factor levels; status (uninfected and infected), line (L10L and L10H) and time (weeks 1 and 3). The plot was created using the “plotMDS.dge” function implemented in the edgeR package. In all plots, L10H_CTL_W1 (red, n = 8), L10H_CTL_W3 (blue, n = 7), L10H_INF_W1 (green, n = 8), L10H_INF_W3 (purple, n = 7), L10L_CTL_W1 (orange, n = 8), L10L_CTL_W3 (yellow, n = 8), L10L_INF_W1 (brown, n = 6), L10L_INF_W3 (pink, n = 8). (PDF 6 kb)
Additional file 2: of Efficacy of naloxone in reducing postictal central respiratory dysfunction in patients with epilepsy: study protocol for a double-blind, randomized, placebo-controlled trial
Creators: name: Rheims, Sylvain
name: Valton, Luc
name: Michel, Véronique
name: Maillard, Louis
name: Navarro, Vincent
name: Convers, Philippe
name: Bartolomei, Fabrice
name: Biraben, Arnaud
name: Crespel, Arielle
name: Derambure, Philippe
name: Toffol, Bertrand De
name: Hirsch, Edouard
name: Kahane, Philippe
name: Martin, Martine
name: Tourniaire, Didier
name: Boulogne, Sébastien
name: Mercier, Catherine
name: Roy, Pascal
name: Ryvlin, Philippe
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: List of investigators in the ENALEPSY study. (DOC 201 kb)
Questa sera su Rai 1 “Margherita delle stelle”
Creators: Valentina Guglielmo
Publisher: name: Media Inaf
Year: 2024

Va in onda oggi, martedì 5 marzo, alle 21.30 su Rai 1 “Margherita delle stelle”, un film prodotto da Rai Fiction e Minerva Pictures che racconta la vita di Margherita Hack, astrofisica e divulgatrice che ha saputo far meravigliare e innamorare dell’astronomia chiunque l’ascoltasse. Con alcune scene girate nelle sedi Inaf di Arcetri, Trieste, e Roma
Marte era un tempo una fucina di biomolecole
Creators: Giuseppe Fiasconaro
Publisher: name: Media Inaf
Year: 2024

Secondo una ricerca condotta da un team di scienziati dell'Università di Tohoku, la materia organica presente oggi su Marte potrebbe essersi originata dalla formaldeide, un precursore di molecole essenziali per la vita. I risultati dello studio, pubblicati su Scientific Reports, indicano inoltre che miliardi di anni fa zuccheri e aminoacidi potrebbero essersi formati sul pianeta in abbondanti quantità, suggerendo l'esistenza di un ambiente maturo per ospitare la vita
Nelle galassie piccole c’è l’Uv buona
Creators: Federico Paletta
Publisher: name: Media Inaf
Year: 2024

A reionizzare l'universo, ponendo fine all’età oscura, potrebbero essere state le galassie nane. È quanto suggerisce uno studio, pubblicato la scorsa settimana su Nature, basato sulla prima analisi spettroscopica della luce di otto galassie estremamente deboli, risalenti al primo miliardo di anni di vita dell’universo, osservate grazie a una lente gravitazionale con il James Webb Space Telescope
Additional file 1: of Efficacy of naloxone in reducing postictal central respiratory dysfunction in patients with epilepsy: study protocol for a double-blind, randomized, placebo-controlled trial
Creators: name: Rheims, Sylvain
name: Valton, Luc
name: Michel, Véronique
name: Maillard, Louis
name: Navarro, Vincent
name: Convers, Philippe
name: Bartolomei, Fabrice
name: Biraben, Arnaud
name: Crespel, Arielle
name: Derambure, Philippe
name: Toffol, Bertrand De
name: Hirsch, Edouard
name: Kahane, Philippe
name: Martin, Martine
name: Tourniaire, Didier
name: Boulogne, Sébastien
name: Mercier, Catherine
name: Roy, Pascal
name: Ryvlin, Philippe
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) 2013 checklist: recommended items to address in a clinical trial protocol and related documents. (DOC 125 kb)
Per la missione Life un banco di prova di nome Terra
Creators: Giuseppe Fiasconaro
Publisher: name: Media Inaf
Year: 2024

Si chiama Large Interferometer For Exoplanets. Life, in breve. È un concetto di missione per indagare l’abitabilità degli esopianeti simili alla Terra e identificare potenziali biofirme nelle loro atmosfere sfruttando la tecnica della Mir nulling interferometry. E promette bene: in un esperimento volto a validarne il potenziale scientifico, condotto utilizzando la Terra come modello, si è dimostrata capace di individuare le tracce rivelatrici della presenza di vita. Lo studio su ApJ
Ecco la coppia più pesante dell’universo
Creators: Marco Malaspina
Publisher: name: Media Inaf
Year: 2024

Usando i dati raccolti con il telescopio Gemini North, un team di astronomi ha misurato la coppia di buchi neri supermassicci più pesante mai trovata: in totale circa 28 miliardi di masse solari. Si uniranno? La fusione tra buchi neri supermassicci è un fenomeno che è stato a lungo previsto, anche se mai osservato. Questa coppia fornisce indizi sul perché un evento del genere sembra sia infrequente nell’universo
Pheidole laevigata Mayr, 1862, n. sp.
Creators: name: Mayr, G.
Publisher: name: Zenodo
Year: 1862
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Pheidole
Pheidole laevigata

description: 5. P. laevigata n. sp.
Soldat. Laenge: 3.6 mm. Glaenzend, rothgelb, Beine heller, Hinterleib braun; Die abstehende Behaarung ist maessig, auch die Beine sind abstehend behaart. Die glaenzenden Mandibeln sind nur mit zerstreuten Puncten versehen. Der Clypeus ist laengsstreifig, in der Mitte fast glatt. Die Vorderhaelfte des Kopfes ist laengsgestreift, die Stirn ohne, die Wangen n it feiner Runzelung zwischen den Streifen; die hintere Haelfte des Kopfes glatt und stark glaenzend. Das Pronotum fast ganz glatt, beiderseits hinten stumpfhoeckerig erweitert. Meso- und Metanotum sind fein und dicht netzmaschig gerunzelt, letzteres mit zwei maessig langen, schief nach hinten und oben gerichteten Dornen. Das zweite Stielchenglied ist beiderseits stumpfwinkelig erweitert und hoechst fein und seicht runzlig. Der Hinterleib ist glatt.
Brasilien (M. C. Vienn.).
description: Published as part of Mayr, G., 1862, Myrmecologische Studien., pp. 649-776 in Verhandlungen der Zoologisch-Botanischen Gesellschaft in Wien 12 on page 747
Democratizing Robotic Process Mining: Literature Review Summary
Creators: name: Hohenadl, Tom
name: Völker, Maximilian
name: Stummeyer, Christian
name: Weske, Mathias
Publisher: name: Zenodo
Year: 2024
Subjects: RPA
User Behavior Mining
Robotic Process Automation
Robotic Process Mining
Onotology
Structured Literature Review

description: This appendix provides supplementary information to support the findings pre-sented in the main paper, titled "Democratizing Robotic Process Mining: AConceptual Framework for User Actions, Tasks, and RPA Bots". The appendixcontains the description of the structured literature review (SLR) as presentedin the original publication as well as a complete list of all included publicationsin the following table.
Additional file 1: Table S1. of A cecropin-like antimicrobial peptide with anti-inflammatory activity from the black fly salivary glands
Creators: name: Wu, Jing
name: Lixian Mu
name: Zhuang, Li
name: Han, Yi
name: Liu, Tong
name: Li, Jun
name: Yang, Yuan
name: Hailong Yang
name: Wei, Lin
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Primer sequences used for cloning and qPCR in this study. (DOC 39Â kb)
Slant, Fan, and Narrow: the Response of Stellar Streams to a Tilting Galactic Disk
Creators: name: Nibauer, Jacob
Publisher: name: Zenodo
Year: 2024

description: Tilting Disk Potential used in Nibauer et al. 2023

Gala implementation of a tilting disk potential around an arbitrary rotation axis. The time-dependent tilt is only implemented in the potential and acceleration, not the density or hessian (these are not used in the analysis currently).
Peptide-Based Synthetic Vaccines (epitope vaccine): Design Strategies and Applications
Creators: name: Dr. Madhuri P1, Dr. Ashmita Debnath2
Publisher: name: The Science world a Monthly e magazine
Year: 2024

description: Among the most significant developments in human health is vaccination. The idea is to stimulate the immune system by injecting it with an antigen, usually bacterial or viral, to elicit a particular reaction and prime it for further infection. It can have a medicinal or preventative purpose. With the development of genetic engineering, next-generation vaccines utilizing epitope-specific antigens are being created to mitigate the possible side effects of traditional vaccinations. Peptide vaccines produce the antigen transiently in a way that is similar to how viral infections produce antigen in vivo. These vaccines activate innate immune responses through Toll-like receptor dependent and independent signaling pathways, as well as humoral (B-lymphocytes) and cellular (T-lymphocyte) immunological responses.
Pheidole cubaensis Mayr, 1862, n. sp.
Creators: name: Mayr, G.
Publisher: name: Zenodo
Year: 1862
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Pheidole
Pheidole cubaensis

description: 6. P. cubaensis n. sp.
Soldat. Laenge: 5 mm. Duenkel rothbraun, der Kopf braeunlich roth, die Fuehler und Beine braeunlich: gelb. Die abstehende Behaarung spaerlich; die Beine sind abstehend behaart. Die Mandibeln ganz ungezaehnt mit geradem, nicht scharfen Kaurande, sie sind glatt, - glaenzend und nur mit einzelnen groben Puncten versehen. Der Clypeus ist in der eingedrueckten Mitte glaenzend, fast glatt, seitliche laengsgerunzelt. Stirn und Wangen sind laengsgestreift, der Scheitel und die Seitengegend des Kopfes verworren gerunzelt. Der Thorax ist fein gerunzelt, am Pro- und Mesonotum oben mit erhabenen Querrunzeln. Das Pronotum ist beiderseits hoeckerartig erweitert mit stumpfer Spitze; das Mesonotum hat ausser den Querrunzelig keine besondere quere Wulst; das Metanotum mit zwei maessig langen, nach aufwaerts geachteten und wenig divergirenden Dornen. Das Stielchen ist fein gerunzelt, das erste. Glied ist vorne gestielt, hinten oben mit der gewoehnlichen queren Wulst, die aber oben bogig ausgeschnitten ist und beiderseits in ein stumpfes Zaehnchen endet; das zweite Glied ist beiderseits in ein schwach nach rueckwaerts gekruemmtes Zaehnchen erweitert. Die Sculptur des nicht stark glaenzenden Hinterleibes ist so wie bei P. opaca hoechst fein und in der Art netzartig gerunzelt, dass rundliche, flache Felder von den Maschen gebildet werden, welche Felder aber glaenzend sind; jene Punkte am Hinterleibe, aus welchen die abstehenden Haare entspringen, sind etwas erhoeht. Die Beine sind glaenzend.
[[worker]] Laenge: 3 mm. Dunkel rothbraun, Mandibeln, Geissel und Tarsen braeunlich gelb, Schienen gelbbraun. Die abstehende Behaarung sehr spaerlich, an den - Beinen am reichlichsten. Die Mandibeln sind laengsgerunzelt, ihr Kaurand vorne mit zwei groesseren Zaehnen, hinter diesen * noch ein bis zwei kleinere, der uebrige Kaurand schneidig. Der Kopf ist fein laengsgerunzelt und sehr fein und dicht netzartig gerunzelt. Pro- und Mesonotum mit Querrunzeln, ersteres beiderseits etwas hoeckerartig erweitert; das gerunzelte Metanotum traegt zwei ziemlich lange, fast aufrechte, etwas divergirende Dornen. Die Querwulst des ersten Stielchengliedes ist nicht, wie beim Soldaten, ausgeschnitten und nicht beiderseits gezaehnt, sondern gerade und seitlich gerundet, das zweite Stielchenglied ist glockenfoermig, vorne schmal, hinten breit, seitlich nicht zahnartig erweitert. Der Hinterleib ist glatt und stark glaenzend; die Beine sind glaenzend.
Aus Cuba, in meiner Sammlung von Herrn Riehl.
description: Published as part of Mayr, G., 1862, Myrmecologische Studien., pp. 649-776 in Verhandlungen der Zoologisch-Botanischen Gesellschaft in Wien 12 on pages 747-748
Additional file 10: of Hologenome analysis of two marine sponges with different microbiomes
Creators: name: Taewoo Ryu
name: Loqmane Seridi
name: Moitinho-Silva, Lucas
name: Oates, Matthew
name: Liew, Yi
name: Mavromatis, Charalampos
name: Xiaolei Wang
name: Haywood, Annika
name: Lafi, Feras
name: Kupresanin, Marija
name: Sougrat, Rachid
name: Alzahrani, Majed
name: Giles, Emily
name: Yanal Ghosheh
name: Schunter, Celia
name: Baumgarten, Sebastian
name: Berumen, Michael
name: Gao, Xin
name: Aranda, Manuel
name: Foret, Sylvain
name: Gough, Julian
name: Voolstra, Christian
name: Hentschel, Ute
name: Ravasi, Timothy
Publisher: name: Figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Antimicrobial peptides encoded in the sponge genomes. (PDF 78Â kb)
Additional file 12: of Hologenome analysis of two marine sponges with different microbiomes
Creators: name: Taewoo Ryu
name: Loqmane Seridi
name: Moitinho-Silva, Lucas
name: Oates, Matthew
name: Liew, Yi
name: Mavromatis, Charalampos
name: Xiaolei Wang
name: Haywood, Annika
name: Lafi, Feras
name: Kupresanin, Marija
name: Sougrat, Rachid
name: Alzahrani, Majed
name: Giles, Emily
name: Yanal Ghosheh
name: Schunter, Celia
name: Baumgarten, Sebastian
name: Berumen, Michael
name: Gao, Xin
name: Aranda, Manuel
name: Foret, Sylvain
name: Gough, Julian
name: Voolstra, Christian
name: Hentschel, Ute
name: Ravasi, Timothy
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Evolutionary rates of selected domains. (a) Boxplot representing the distribution of the mean Ka/Ks for each protein domain between sponge pairs. (b) The mean Ka/Ks of each protein domain is shown. This analysis was restricted to the protein domains given in Fig.Â 2 that passed our quality control step (see Methods). (PDF 194Â kb)
MOESM1 of Genotyping of Salmonella Typhi using 8-loci multi locus VNTR analysis
Creators: name: Hongxia Wang
name: Baowei Diao
name: Zhigang Cui
name: Meiying Yan
name: Kan, Biao
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Pharmacology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Table S1. The characteristics of VNTR loci and primers for amplification of VNTRs. Table S2. The endogenous 3bp DNA ladder and internal marker. Table S3. Numbers of repetitions at 8 loci in the 103 S. Typhi strains. Table S4. 7 bp deletion in TR4500. Table S5. 15 bp insertion in TR4500. Table S6. 55 bp insertion in TR4500. Table S7. 711 bp insertion in Sal10.
Pheidole cuitensis Mayr, 1862, n. sp.
Creators: name: Mayr, G.
Publisher: name: Zenodo
Year: 1862
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Pheidole
Pheidole cuitensis

description: 7. P. cuitensis n. sp.
Soldat. Laenge des Koerpers: 4.4 mm. Schmutzig gelb, ziemlich glaenzend, Kopf, oefters der Thorax gelbroth, Hinterleib hinten braeunlich, Kaurand der Mandibeln schwarz. Mandibeln fast glatt, nur zerstreut punctirt. Kopf kielartig laengsgestreift, hinten netzartig, Clypeus fast glatt. Thorax fast glanzlos, runzlig quergestreift, Scheibe des Pronotum glaenzend und schwach gestreift. Pronotum gerundet, Mesonotum mit dicker Querwulst, Dornen des Metanotum lang, spitz. Stielchen fein gerunzelt, zweites Glied beiderseits mit stumpfem Kegel. Hinterleib glatt und glaenzend.
[[worker]] Laenge: 3.3 mm. Roethlich gelb, glaenzend, Kopf und Thorax gelbroth, Hinterleib hinten braeunlich, Tarsen blassgelb. Mandibeln laengsgestreift, Clypeus und Stirnfeld glatt, Stirn fein und sehr seicht laengsgerunzelt, Wangen und Augengegend staerker laengsgerunzelt, Scheitel ziemlich glatt. Pronotum auf der Scheibe glatt, seitlich laengsgerunzelt, Meso- und Metanotum fingerhutartig punctirt, oben mit Querrunzeln, Metanotum mit zwei an der Basis' breiten Dornen. Stielchen fein gerunzelt, zweites Glied seitlich gerundet. Hinterleib glatt.
[[queen]] Laenge: 7 mm. Gelblich roth, Hinterleib, Stielchen und Kaurand der Mandibeln braun, Thorax rothbraun oder gelblichroth. Pronotum theils glatt, theils gestreift, Mesonotum laengsgestreift, Scheibe des Schildchens fast glatt, am Rande gerunzelt, die Seiten des Thorax gestreift, Metanotum zwischen den maessig langen, an der Basis ziemlich breiten Dornen glatt. Stielchen scharf quer gerunzelt, das zweite Glied seitlich stumpf kegelig. Hinterleib glatt und glaenzend.
[[male]] Laenge: 4 - 4.2 mm- Braungelb, Mesonotum meist am dunkelsten, Fuehler und Beine am blassesten. Mandibeln fein und seicht laengsgerunzelt, Clypeus hoechst fein und seicht gerunzelt, der uebrige Kopf fein verworren gerunzelt, hier und da mit einer Laengsrunzel. Pronotum fast glatt und glaenzend, seitlich sehr seicht laengsgerunzelt, Mesonotum fein laengsstreifig, in der Mitte glatt, Seiten des Thorax fast glatt. Metanotum fein netzaderig gerunzelt, glanzlos, mit, einzelnen Laengsrunzeln, nur mit undeutlichen Hoeckern. Das erste Stielchenglied fein gerunzelt, das zweite glatt. Hinterleib glatt und glaenzend.
Chili (Novara).
description: Published as part of Mayr, G., 1862, Myrmecologische Studien., pp. 649-776 in Verhandlungen der Zoologisch-Botanischen Gesellschaft in Wien 12 on pages 748-749
Additional file 3: of Hologenome analysis of two marine sponges with different microbiomes
Creators: name: Taewoo Ryu
name: Loqmane Seridi
name: Moitinho-Silva, Lucas
name: Oates, Matthew
name: Liew, Yi
name: Mavromatis, Charalampos
name: Xiaolei Wang
name: Haywood, Annika
name: Lafi, Feras
name: Kupresanin, Marija
name: Sougrat, Rachid
name: Alzahrani, Majed
name: Giles, Emily
name: Yanal Ghosheh
name: Schunter, Celia
name: Baumgarten, Sebastian
name: Berumen, Michael
name: Gao, Xin
name: Aranda, Manuel
name: Foret, Sylvain
name: Gough, Julian
name: Voolstra, Christian
name: Hentschel, Ute
name: Ravasi, Timothy
Publisher: name: Figshare
Year: 2016
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Detailed statistics of our sponge genomes and transcriptomes. (PDF 263Â kb)
Additional file 5: of Hologenome analysis of two marine sponges with different microbiomes
Creators: name: Taewoo Ryu
name: Loqmane Seridi
name: Moitinho-Silva, Lucas
name: Oates, Matthew
name: Liew, Yi
name: Mavromatis, Charalampos
name: Xiaolei Wang
name: Haywood, Annika
name: Lafi, Feras
name: Kupresanin, Marija
name: Sougrat, Rachid
name: Alzahrani, Majed
name: Giles, Emily
name: Yanal Ghosheh
name: Schunter, Celia
name: Baumgarten, Sebastian
name: Berumen, Michael
name: Gao, Xin
name: Aranda, Manuel
name: Foret, Sylvain
name: Gough, Julian
name: Voolstra, Christian
name: Hentschel, Ute
name: Ravasi, Timothy
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Over- or under-represented Superfamily domains in SC and XT. Superfamily domains that are unusually enriched in SC and XT. Domains with |deviation|â  >â  0.5 are shown. (PDF 64Â kb)
Association between physical intimate partner violence and postpartum contraceptive use in the United States–evidence from PRAMS 2016–2021
Creators: name: Barden-O’Fallon J
name: Ijdi R.-E
Publisher: name: Public Library of Science
Year: 2024

description: Objective Intimate Partner Violence (IPV) continues to be a major global public health concern, impacting physical and psychological well-being of individuals, including their reproductive and sexual health. The objective of this study is to examine the association between physical intimate partner violence and the utilization of contraception during the postpartum period in the United States. Method This study used data from the CDC’s Pregnancy Risk Assessment Monitoring System (PRAMS) survey study phase 8, covering 2016–2021. The sample included 165,204 women reporting physical IPV during pregnancy or 12 months before their last pregnancy and their postpartum contraceptive use. Descriptive, bivariate, and logistic regressions were used to analyze the relationship between IPV and postpartum contraceptive use, adjusting for relevant factors and addressing sampling weights. Results The study found a 3.2% prevalence of physical IPV, with state variances ranging from 2.2% to 5.5%. Among women who experienced physical IPV, 91.0% used contraception, compared to 94.5% of those who did not experience physical IPV. Experiencing physical IPV significantly decreased the likelihood of using any postpartum contraceptive method by 42% (aOR: 0.58; 95% CI: 0.48–0.70) compared to those who did not experience physical IPV during the same period, after adjusting for covariates. Factors that increased the probability of using contraception during the postpartum period included women’s higher educational attainment, being married or cohabitating, being employed anytime during pregnancy, and having an unintended last pregnancy. Conclusion This study highlights the significant association between physical IPV and reduced use of postpartum contraception in the United States. It calls for the integration of IPV considerations into public health policies and clinical initiatives to improve maternal well-being.
Additional file 1: of Stochastic modeling suggests that noise reduces differentiation efficiency by inducing a heterogeneous drug response in glioma differentiation therapy
Creators: name: Xiaoqiang Sun
name: Jiajun Zhang
name: Zhao, Qi
name: Chen, Xing
name: Wenbo Zhu
name: Guangmei Yan
name: Tianshou Zhou
Publisher: name: Figshare
Year: 2016
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Text S1. Cyclin D1 feedback increases variability in signal transduction and phenotypic transition. Figure S1 Both the downregulation of cyclin D1 expression and inhibition of the function of the cyclin D1/CDK4/6 complex induce the differentiation of human glioblastoma U87-MG cells into glia-like cells. Figure S2 Comparison between the simulated time-course of GFAP levels at a 5Â % noise intensity and the experimental data. Figure S3 The coefficient of variation of cyclin D1 and GFAP levels affected by cyclin D1 feedback during glioma differentiation. Figure S4 The effect of inhibition of cyclin D1 feedback simulated with the ANM model. Figure S5 The effect of inhibition of cyclin D1 feedback simulated with the CLE model. Figure S6 Trajectories of all signaling components in relation to noise simulated with the CLE model. Table S1 Parameter values involved in the model. Table S2 Initial values of the mathematical model. (DOC 1244Â kb)
Communication, Dissemination and Exploitation Plan
Creators: name: Aprile, Giulia
name: Schoenbeck, Axel
Publisher: name: Zenodo
Year: 2024

description: The Communication, Dissemination and Exploitation Plan is Deliverable 7.1 within WP7 - Dissemination, exploitation and impact of the QUANTIFY Project. The document describes the approaches and strategies to communication, dissemination and subsequent exploitation of the project results.
Pheidole opaca Mayr, 1862, n. sp.
Creators: name: Mayr, G.
Publisher: name: Zenodo
Year: 1862
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Pheidole
Pheidole opaca

description: 8. P. opaca n. sp.
Soldat. Laenge: 7.5 mm. Matt, braunroth, Kopf rothbraun, Stirn, Fuehlergruben und Wangen roth, Hinterleibsende braun. Die abstehende Behaarung fein und spaerlich, auf den Beinen reichlicher. Die Mandibeln sind glaenzend, glatt, nur mit einigen entfernten Puncten besetzt, eben so ist das vertiefte Stirnfeld glaenzend und glatt; der uebrige Kopf aber zeigt keine Spur von Glanz, er ist sehr dicht fingerhutartig punctirt und von vielen erhabenen Laengsrunzeln, auf der Stirn aber und auf dem Clypeus von solchen Laengsstreifen durchzogen. Der ganze Thorax ist so wie der Kopf sehr dicht punctirt; das Pronotum ist beiderseits ziemlich nahe dem Hinterrande in einen stumpfspitzig auslaufenden, an der Basis dicken Hoecker ausgezogen; das Metanotum hat zwei kraeftige Dornen, welche nach oben und etwas nach hinten gerichtet und an der Basis ziemlich dick sind. Das Stielchen ist wie der Kopf und Thorax sehr fein und sehr dicht punctirt, das erste Glied ist hinten oben ausgerandet, das zweite Glied ist glockenfoermig, vorne schmal, etwas vor dem hinteren Ende am breitesten und seitlich gerundet. Der Hinterleib ist vollkommen matt, hoechst fein und regelmaessig netzmaschig, die Maschen selbst sehr fein rauh, ohne dass man im Stande waere, selbst mit einer starken Loupe die Sculptur zu erkennen. Die mit abstehenden Borstenhaaren versehenen Beine sind ebenfalls glanzlos und hoechst fein punctirt.
[[worker]] Laenge: 4.5 mm. Matt, braeunlich rothgelb, Geissel, besonders am Ende, rothbraun, der Kopf beiderseits schwach braeunlich angeraucht. Die abstehende Behaarung ist massig und ziemlich lang. Der ganze Kopf, sogar die Mandibeln und das Stirnfeld, sind sehr dicht und fein fingerhutartig punctirt, ueberdiess sind die Wangen, die Stirn, der Scheitel und die Seiten des Kopfes von Laengsrunzeln durchzogen, welche sich besonders am Scheitel netzartig vereinigen. Der Thorax ist wie der Kopf punctirt und netzartig von Runzeln durchzogen. Das Pronotum ist nahe dem Hinterrande beiderseits mit einem kleinen Hoecker versehen. Das Metanotum traegt zwei starke nach oben und etwas nach hinten gerichtete, sehr spitze, lange Dornen.
Das Stielchen ist sehr fein und sehr dicht punctirt, in der Form aber gleicht es dem des Soldaten, das zweite Glied ist aber verhaeltnissmaessig viel schmaeler. Der Hinterleib zeigt eine Sculptur wie beim Soldaten, sie ist aber so enorm fein, dass man sie bei starker Vergroesserung kaum sieht, am deutlichsten ist sie noch am ersten Segmente. Die Beine sind hoechst fein punctirt und matt.
Im Gebiete des Amazonenstromes (M. C. Vienn.).
Pheidole mordax Smith ist, wie ich aus typischen Exemplaren ersehe, eine echte Pheidole.
description: Published as part of Mayr, G., 1862, Myrmecologische Studien., pp. 649-776 in Verhandlungen der Zoologisch-Botanischen Gesellschaft in Wien 12 on pages 749-750
Additional file 7: of Hologenome analysis of two marine sponges with different microbiomes
Creators: name: Taewoo Ryu
name: Loqmane Seridi
name: Moitinho-Silva, Lucas
name: Oates, Matthew
name: Liew, Yi
name: Mavromatis, Charalampos
name: Xiaolei Wang
name: Haywood, Annika
name: Lafi, Feras
name: Kupresanin, Marija
name: Sougrat, Rachid
name: Alzahrani, Majed
name: Giles, Emily
name: Yanal Ghosheh
name: Schunter, Celia
name: Baumgarten, Sebastian
name: Berumen, Michael
name: Gao, Xin
name: Aranda, Manuel
name: Foret, Sylvain
name: Gough, Julian
name: Voolstra, Christian
name: Hentschel, Ute
name: Ravasi, Timothy
Publisher: name: Figshare
Year: 2016
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Supplementary information describing relationship between Xestospongia testudinaria and Xestospongia muta, antimicrobial peptides, and evolutionary rates of innate immune domains in analyzed sponge genomes. (PDF 790Â kb)
Additional file 1: Table S1. of WT1-AS promotes cell apoptosis in hepatocellular carcinoma through down-regulating of WT1
Creators: name: Lv, Long
name: Chen, Gong
name: Jianping Zhou
name: Li, Jun
name: Jianping Gong
Publisher: name: Figshare
Year: 2015
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Sequence information for primer and siRNA. (DOCX 13Â kb)
Additional file 8: of Hologenome analysis of two marine sponges with different microbiomes
Creators: name: Taewoo Ryu
name: Loqmane Seridi
name: Moitinho-Silva, Lucas
name: Oates, Matthew
name: Liew, Yi
name: Mavromatis, Charalampos
name: Xiaolei Wang
name: Haywood, Annika
name: Lafi, Feras
name: Kupresanin, Marija
name: Sougrat, Rachid
name: Alzahrani, Majed
name: Giles, Emily
name: Yanal Ghosheh
name: Schunter, Celia
name: Baumgarten, Sebastian
name: Berumen, Michael
name: Gao, Xin
name: Aranda, Manuel
name: Foret, Sylvain
name: Gough, Julian
name: Voolstra, Christian
name: Hentschel, Ute
name: Ravasi, Timothy
Publisher: name: Figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Statistics of compiled AMPs for broad taxonomic group. (PDF 34Â kb)
The ATR inhibition by Elimusertib enhances the radiosensitivity of MDA-MB-231 triple negative breast cancer in vitro
Creators: name: Eskiler, Gamze Guney
name: Halis, Hatice
name: Hamarat, Kaan Furkan
name: Derlioglu, Rabia Rana
name: Ugurlu, Berat Tugrul
name: Haciefendi, Ayten
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: DNA damage response (DDR) is the principal mechanism regulating genomic stability and cell cycle checkpoint activation by coordinating DNA repair and apoptotic pathways. Ataxia telangiectasia and Rad3-related protein (ATR) play a significant role in the DDR due to its capability to detect a wide spectrum of DNA damage. Therefore, targeting DDR, specifically ATR, is a promising therapeutic strategy in cancer treatment. Furthermore, the inhibition of ATR sensitizes cancer cells to radiotherapy (RT). Herein, we, for the first time, investigated the synergistic effects of Elimusertib (BAY-1895344) as a highly potent selective ATR inhibitor with RT combination in triple-negative breast cancer (TNBC), in vitro. MDA-MB-231 TNBC cells were firstly treated with different concentrations of Elimusertib for 24 h and then exposed to 4 and 8 Gy of X-ray irradiation. After post-irradiation for 72 h, WST-1, Annexin V, cell cycle, acridine orange/propidium iodide, mitochondria staining and western blot analysis were conducted. Our findings showed that 4 Gy irradiation and lower doses (especially 2 and 4 nM) of Elimusertib combination exerted a considerable anticancer activity at 72 h post-irradiation through apoptotic cell death, marked nuclear and mitochondrial damages and the suppression of ATR-Chk1 based DDR mechanism. ATR inhibition by Elimusertib in combination with RT may be a promising new treatment strategy in the treatment of TNBC. However, further experiments should be performed to elucidate the underlying molecular mechanisms of the therapeutic efficacy of this combination treatment and its association with DNS repair mechanisms in TNBC, in vitro and in vivo.
Pheidologeton ocelliferus
Creators: name: Mayr, G.
Publisher: name: Zenodo
Year: 1862
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Pheidologeton
Pheidologeton ocelliferus

description: 1. P. ocelliferus Smith.
Von Smith unter dem Namen Pheidole ocellifera beschrieben, Hongkong (Novara).
Figur 13. Fuehler eines kleinen [[worker]].
description: Published as part of Mayr, G., 1862, Myrmecologische Studien., pp. 649-776 in Verhandlungen der Zoologisch-Botanischen Gesellschaft in Wien 12 on page 750