cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Nanoscale detection and real-time monitoring of free radicals in a single living cell under the stimulation of targeting moieties using a nanodiamond quantum sensor
Creators: name: Wu, Kaiqi
name: Lu, Qi
name: Sow, Maabur
name: Balasubramanian, Priyadharshini
name: Jelezko, Fedor
name: Weil, Tanja
name: Wu, Yingke
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Space Science
Medicine
Cell Biology
Molecular Biology
Biotechnology
Chemical Sciences not elsewhere classified
Developmental Biology
Cancer

description: Intracellular radicals play important roles in cell signaling and regulation of growth factors, cytokines, transcription, apoptosis, and immunomodulation, among others. To gain a more comprehensive understanding of their biological functions from a spatio-temporal pers­pective, there is a great need for nanoscale sensitive tools that allow real-time detection of these reactive species. Currently, intracellular radical probes are based on chemical reactions that could significantly alter radical levels during detection. Due to the excellent bio­compatibility and favorable photophysical properties of nitrogen-vacancy (NV–) centers in fluorescent nanodiamonds (fNDs), the fNDs can serve as a powerful and chemically inert nanotool for intracellular radical detection. In this study, a positively charged nanogel (NG) coating was prepared to prevent the precipitation of fNDs and promote cellular internalization. After internalization of nanodiamond-nanogels (fND-NGs), different stimulators, namely somatostatin (SST), triphenylphosphonium (TPP), and trans-activator of transcription (TAT) peptide, which are widely used cell- or organelle-targeting ligands in medicine, drug delivery, and diagnostics, were applied to stimulate the cells. In parallel, the intracellular radical changes under stimulation of SST, TPP, and TAT ligands were monitored by fND-NGs in a home-built optically detected magnetic resonance (ODMR) microscope. Our method allows for detecting intracellular radicals in-situ and monitoring their real-time changes during incubation with the targeting ligands in a single living cell. We believe that our method will provide insights into the generation of radical stress in cells, which could improve our fundamental understanding of the pharmacology and signaling pathways of widely used cell- and organelle-targeting ligands associated with free radicals.
Structure of solutions near the initial singularity for the surface-symmetric Einstein-Vlasov system
Creators: name: Tchapnda, Sophonie Blaise
Publisher: name: arXiv
Year: 2004
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Results on the behaviour in the past time direction of cosmological models with collisionless matter and a cosmological constant $Λ$ are presented. It is shown that under the assumption of non-positive $Λ$ and spherical or plane symmetry the area radius goes to zero at the initial singularity. Under a smallness assumption on the initial data, these properties hold in the case of hyperbolic symmetry and negative $Λ$ as well as in the positive $Λ$ case. Furthermore in the latter cases past global existence of spatially homogeneous solutions is proved for generic initial data. The early-time asymptotics is shown to be Kasner-like for small data.
description: 17 pages
Boosted regression (boosting): An introductory tutorial and a Stata plugin
Creators: name: Schonlau, Matthias
name: Schonlau, Matthias
Publisher: name: Unknown
Year: 2005
Subjects: subject: Research Methods/ Statistical Methods
subject: boost
subject: boosted regression
subject: boosting
subject: data mining

description: Boosting, or boosted regression, is a recent data-mining technique that has shown considerable success in predictive accuracy. This article gives an overview of boosting and introduces a new Stata command, boost, that implements the boosting algorithm described in Hastie, Tibshirani, and Friedman (2001, 322). The plugin is illustrated with a Gaussian and a logistic regression example. In the Gaussian regression example, the R2 value computed on a test dataset is R2 = 21.3% for linear regression and R2 = 93.8% for boosting. In the logistic regression example, stepwise logistic regression correctly classifies 54.1% of the observations in a test dataset versus 76.0% for boosted logistic regression. Currently, boost accommodates Gaussian (normal), logistic, and Poisson boosted regression. boost is implemented as a Windows C++ plugin.
Additional file 1 of Distribution of 31 endocrine-disrupting compounds in the Taihu Lake and application of the fish plasma model
Creators: name: Yifan Bao
name: Wenping Huang
name: Hu, Xialin
name: Daqiang Yin
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Text. Chemicals and standards. Analytical determination of EDCs. Table S1. CAS, molecular weight, structural formula and log Kow of the 31 selected EDCs. Table S2. Common names, Chinese name, scientific names, sampling number (N), Length and weight of wild fish from the Taihu Lake. Table S3. MS parameters and retention time of 31 EDCs. Table S4. Linear range, correlation coefficients (r2), regression equations, LOQ of 31 EDCs and LODs in Water. Table S5. Linear range, correlation coefficients (r2), regression equations, LOQ of 31 EDCs and LODs in fish plasma. Table S6. Comparison of EDC concentrations at home and abroad (ng/L). Figure S1. The number of detected EDCs in each sampling sites in summer and winter in the Taihu Lake.
Predictions for $B \to K γγ$ decays
Creators: name: Hiller, Gudrun
name: Safir, A. Salim
Publisher: name: arXiv
Year: 2004
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present a phenomenological study of the rare double radiative decay $B\to K γγ$ in the Standard Model (SM) and beyond. Using the operator product expansion (OPE) technique, we estimate the short-distance (SD) contribution to the decay amplitude in a region of the phase space which is around the point where all decay products have energy $\sim m_b/3$ in the rest frame of the $B$-meson. At lowest order in 1/Q, where $Q$ is of order $m_b$, the $B\to K γγ$ matrix element is then expressed in terms of the usual $B\to K$ form factors known from semileptonic rare decays. The integrated SD branching ratio in the SM in the OPE region turns out to be $Δ{\cal{B}}(B \to K γγ)_{SM}^{OPE} \simeq 1 \times 10^{-9}$. We work out the di-photon invariant mass distribution with and without the resonant background through $B\to K \{η_c,χ_{c0}\}\to Kγγ$. In the SM, the resonance contribution is dominant in the region of phase space where the OPE is valid. The present experimental upper limit on $B_s \to τ^+ τ^-$ decays, which constrains the scalar/pseudoscalar Four-Fermi operators with $τ^+ τ^-$, leaves considerable room for new physics in the one-particle-irreducible contribution to $B\to K γγ$ decays. In this case, we find that the SD $B\to K γγ$ branching ratio can be enhanced by one order of magnitude with respect to its SM value and the SD contribution can lie outside of the resonance peaks.
description: 17 pages, 4 figures; Note added on Schouten identity and 2 references added; v4: typos in Eqs (8), (44) and erroneous statement on mixing before Eq (44) fixed. All results and conclusions unchanged
Calculation of hyperfine magnetic anomaly in many-electron atoms
Creators: name: Konovalova, E. A.
name: Demidov, Yu. A.
name: Kozlov, M. G.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: The precision measurements of the ratio of hyperfine structure constants for $s_{1/2}$ and $p_{1/2}$ states allow us to estimate the difference between hyperfine magnetic anomalies for these levels. We calculate the atomic factor in order to recover the absolute values of the hyperfine magnetic anomalies from their difference. Taking into account the hyperfine anomaly correction allows one to increase the accuracy of determining the g-factors of short-lived isotopes by more than an order of magnitude.
Numerical consistency check between two approaches to radiative corrections for neutrino masses and mixings
Creators: name: Das, Mrinal Kumar
name: Patgiri, Mahadev
name: Singh, N. Nimai
Publisher: name: arXiv
Year: 2004
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We briefly outline the two popular approaches on radiative corrections to neutrino masses and mixing angles, and then carry out a detailed numerical analysis for a consistency check between them in MSSM. We find that the two approaches are nearly consistent with a small discrepancy of a factor of 13 percent in mass eigenvalues at low energy scale, but the predictions on mixing angles are almost consistent. We check the stability of the three types of neutrino models, i.e., hierarchical, inverted hierarchical and degenerate models, under radiative corrections, using both approaches, and find consistent conclusions. The neutrino mass models which are found to be stable under radiative corrections in MSSM are the normal hierarchical model and the inverted hierarchical model with opposite CP parity. We also carry out numerical analysis on some important conjectures related to radiative corrections in MSSM, viz., radiative magnification of solar and atmospheric mixings in case of nearly degenerate model having same CP parity (MPR conjecture) and radiative generation of solar mass scale in exactly two-fold degenerate model with opposite CP parity and non-zero reactor angle (JM conjecture). We observe certain exceptions to these conjectures. Finally the effect of scale-dependent vacuum expectation value in neutrino mass renormalisation is discussed.
description: 26 pages, 5 figures,references added, typos corrected and text modified
Effect of a Relapse Prevention Program in a Correctional Setting: Motivation, Relapse, and Stress Management Strategies
Creators: name: Martín Coca, Abdón
name: MARTÍN HERRERO, JOSÉ ANTONIO
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 520304
subject: Health psychology
classificationCode: 520302
subject: Clinical psychology

description: This study evaluates the efficacy of a Relapse Prevention Program (RPP) tailored for a correctional setting, focusing on enhancing motivation, anticipating relapse risks, and improving stress management strategies. The program integrates Marlatt's Relapse Prevention model with the Behavior Change Wheel (BCW) framework to optimize intervention outcomes.A quasi-experimental design involved 28 participants across three groups: a mental health module, a therapeutic-educational unit, and a women's module. The 12-week intervention incorporated cognitive-behavioral techniques and targeted skill-building sessions. Program effectiveness was assessed using the SOCRATES, AWARE, and COPE scales, supplemented by a Global Questionnaire.The SOCRATES scale indicated a significant enhancement in participants' motivation to sustain abstinence, reflecting increased confidence and readiness to confront addiction and embrace positive changes. However, the AWARE scale did not show significant improvement in anticipating relapse risks, suggesting a longer intervention may be needed. The COPE scale revealed significant advancements in stress management, particularly in the women's group, who showed increased use of active coping and positive reinterpretation strategies.This study supports the efficacy of RPPs incorporating the BCW framework. The findings highlight the need for gender-specific adaptations in correctional settings to address challenges faced by women. Future research should focus on larger sample sizes and extended follow-up periods to confirm the sustainability of these interventions.
Four-quark exotic mesons
Creators: name: Agaev, S. S.
name: Azizi, K.
name: Sundu, H.
Publisher: name: arXiv
Year: 2020
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We review our investigations devoted to the analysis of the resonances $ Z_{c}(3900)$, $Z_{c}(4430)$, $Z_{c}(4100)$, $X(4140)$, $X(4274)$, $a_1(1420)$ , $Y(4660)$, $X(2100)$, $X(2239)$ and $Y(2175)$ discovered in various processes by Belle, BaBar, BESIII, D0, CDF, CMS, LHCb and COMPASS collaborations. These resonances are considered as serious candidates to four-quark (tetraquark) exotic mesons. We treat all of them as diquark-antidiquark states with relevant spin-parities, find their masses and couplings, as well as explore their dominant strong decay channels. Calculations are performed in the context of the QCD sum rule method. Thus, the spectroscopic parameters of the tetraquarks are evaluated using the two-point sum rules. For computations of the strong couplings $G_{TM_1M_2}$, corresponding to the vertices $TM_1M_2$ and necessary to find the partial widths of the strong decays $T \to M_1M_2$, we employ either the three-point or full/approximate versions of the QCD light-cone sum rules methods. Obtained results are compared with available experimental data, and with predictions of other theoretical studies.
description: 56 Pages, 14 Figures and 8 Tables. A review based on arXiv:1706.01216, 1812.10094, 1703.10323, 1711.05977, 1805.04705, 1906.04061, 1911.09743
Additional file 1 of Effect of mechanical power on intensive care mortality in ARDS patients
Creators: name: Coppola, Silvia
name: Caccioppola, Alessio
name: Froio, Sara
name: Formenti, Paolo
name: Giorgis, Valentina De
name: Galanti, Valentina
name: Consonni, Dario
name: Chiumello, Davide
Publisher: name: figshare
Year: 2020
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1. Formulas of the physiological variables. Formulas used in the paper are reported in the supplemental material.
Introduction to game-theory calculations
Creators: name: Orsini, Nicola
name: Rizzuto, Debora
name: Nante, Nicola
name: Orsini, Nicola
name: Rizzuto, Debora
name: Nante, Nicola
Publisher: name: Unknown
Year: 2005
Subjects: subject: Research Methods/ Statistical Methods
subject: Game theory
subject: Nash equilibrium
subject: payoff matrix
subject: zero-sum game
subject: game tree

description: Game theory can be defined as the study of mathematical models of conflict and cooperation between intelligent and rational decision makers (Myerson 1991). Game-theory concepts apply in economy, sociology, biology, and health care, and whenever the actions of several agents (individuals, groups, or any combination of these) are interdependent. We present a new command gamet to represent the extensive form (game tree) and the strategic form (payoff matrix) of a noncooperative game and to identify the solution of a nonzero and zero-sum game through dominant and dominated strategies, iterated elimination of dominated strategies, and Nash equilibrium in pure and fully mixed strategies. Further, gamet can identify the solution of a zero-sum game through maximin criterion and the solution of an extensive form game through backward induction.
Tunable and broadband coherent perfect absorbers with nonlinear and amplification performance based on asymmetric bifacial graphene metasurfaces
Creators: name: Guo, Tianjing
name: Argyropoulos, Christos
Publisher: name: arXiv
Year: 2020
Subjects: subject: Optics (physics.optics)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: We present an asymmetric bifacial graphene metasurface to realize tunable and broadband coherent perfect absorption (CPA) at terahertz (THz) frequencies. The proposed design is composed of two dissimilar graphene square patch metasurfaces stacked over an ultrathin dielectric substrate. Nonlinear CPA performance without resorting to optical nonlinearities and amplification are demonstrated based on wave interference phenomena taking place along and inside this subwavelength structure. Broadband asymmetric reflection from opposite directions is obtained in the case of single wave illumination. This response acts as a precursor to the presented tunable and broadband nonlinear CPA performance and the inverse response to absorption, i.e., amplification, when an additional input wave coherently interacts with the opposite propagating incident wave. The proposed ultrathin broadband CPA device is expected to be a vital component to several new on-chip THz communication devices, such as optical modulators, sensors, photodetectors, and all-optical small-signal amplifiers.
Quantum theory as a statistical theory under symmetry
Creators: name: Helland, Inge S.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Both statistics and quantum theory deal with prediction using probability. We will show that there can be established a connection between these two areas. This will at the same time suggest a new, less formalistic way of looking upon basic quantum theory. A total parameter space $Φ$, equipped with a group $G$ of transformations, gives the mental image of some quantum system, in such a way that only certain components, functions of the total parameter $ϕ$ can be estimated. Choose an experiment/ question $a$, and get from this a parameter space $Λ^{a}$, perhaps after some model reduction compatible with the group structure. The essentially statistical construction of this paper leads under natural assumptions to the basic axioms of quantum mechanics, and thus implies a new statistical interpretation of this traditionally very formal theory. The probabilities are introduced via Born's formula, and this formula is proved from general, reasonable assumptions, essentially symmetry assumptions. The theory is illustrated by a simple macroscopic example, and by the example of a spin 1/2 particle. As a last example we show a connection to inference between related macroscropic experiments under symmetry.
description: The paper has been withdrawn because it is outdated
Using density-distribution sunflower plots to explore bivariate relationships in dense data
Creators: name: Dupont, William D.
name: Plummer, W. Dale
name: Dupont, William D.
name: Plummer, W. Dale
Publisher: name: Unknown
Year: 2005
Subjects: subject: Research Methods/ Statistical Methods
subject: scatterplot
subject: sunflower plot
subject: bivariate data
subject: density plot
subject: probability density function
subject: graphical statistics

description: Density-distribution sunflower plots are used to display high-density bivariate data. They are useful for data where a conventional scatterplot is difficult to read due to overstriking of the plot symbol. The x–y plane is subdivided into a lattice of small, regular, hexagonal bins. These bins are divided into low-, medium-, and high-density groups. In low-density bins, the individual observations are plotted as in a conventional scatterplot. Medium- and high-density bins contain light and dark sunflowers, respectively. In a light sunflower, each petal represents one observation. In a dark sunflower, each petal represents a specific number of observations. The user can control the sizes and colors of the sunflowers. By selecting appropriate colors and sizes for the light and dark sunflowers, plots can be obtained that give both the overall sense of the data-density distribution, as well as the number of data points in any given region.
Alice and the Foucault Pendulum: the land of action-angle variables
Creators: name: Boulanger, Niciolas
name: Buisseret, Fabien
Publisher: name: arXiv
Year: 2020
Subjects: subject: History and Philosophy of Physics (physics.hist-ph)
subject: Physics Education (physics.ed-ph)
subject: Popular Physics (physics.pop-ph)
subject: FOS: Physical sciences

description: Since the pioneering works of Newton $(1643-1727)$, Mechanics has been constantly reinventing itself: reformulated in particular by Lagrange $(1736-1813)$ then Hamilton $(1805-1865)$, it now offers powerful conceptual and mathematical tools for the exploration of the most complex dynamical systems, essentially via the action-angle variables formulation and more generally through the theory of canonical transformations. We give the reader an overview of these different formulations through the well-known example of Foucault's pendulum, a device created by Foucault $(1819-1868)$ and first installed in the Panthéon (Paris, France) in 1851 to display the Earth's rotation. The apparent simplicity of the Foucault pendulum is indeed an open door to the most contemporary ramifications of Classical Mechanics. We stress that the action-angle variable formalism is not necessary to understand Foucault's pendulum. The latter is simply taken as well-known simple dynamical system used to exemplify modern concepts that are crucial in order to understand more complicated dynamical systems. The Foucault pendulum installed in the collegiate church of Sainte-Waudru (Mons, Belgium) will allow us to numerically estimate the different quantities introduced. A free adaptation of excerpts from "Alice's Adventures in Wonderland" will offer the reader some poetic breaths.
Long Range Frustrations in a Spin Glass Model of the Vertex Cover Problem
Creators: name: Zhou, Haijun
Publisher: name: arXiv
Year: 2004
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Computational Complexity (cs.CC)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: In a spin glass system on a random graph, some vertices have their spins changing among different configurations of a ground--state domain. Long range frustrations may exist among these unfrozen vertices in the sense that certain combinations of spin values for these vertices may never appear in any configuration of this domain. We present a mean field theory to tackle such long range frustrations and apply it to the NP-hard minimum vertex cover (hard-core gas condensation) problem. Our analytical results on the ground-state energy density and on the fraction of frozen vertices are in good agreement with known numerical and mathematical results.
description: An erratum is added to the main text. 5 pages, 5 figures
T-odd generalized and quasi transverse momentum dependent parton distribution in a scalar spectator model
Creators: name: Luo, Xuan
name: Sun, Hao
Publisher: name: arXiv
Year: 2020
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Generalized transverse momentum dependent parton distributions (GTMDs), as mother funtions of transverse momentum dependent parton distributions (TMDs) and generalized parton distributions (GPDs), encode the most general parton structure of hadrons. We calculate four twist-two time reversal odd GTMDs of pion in a scalar spectator model. We study the dependence of GTMDs on the longitudinal momentum fraction $x$ carried by the active quark and the transverse momentum $|\vec k_T|$ for different values of skewness $ξ$ defined as the longitudinal momentum transferred to the proton as well as the total momentum $|\vecΔ_T|$ transferred to the proton. In addition, the quasi-TMDs and quasi-GPDs of pion have also been investigated in this paper.
A simple approach to fit the beta-binomial model
Creators: name: Guimaraes, Paulo De Freitas
name: Guimaraes, Paulo De Freitas
Publisher: name: Unknown
Year: 2005
Subjects: subject: Research Methods/ Statistical Methods
subject: overdispersion
subject: beta binomial
subject: Dirichlet multinomial
subject: fixed-effects negative binomial

description: In this paper, I show how to estimate the parameters of the beta-binomial distribution and its multivariate generalization, the Dirichlet-multinomial distribution. This approach involves no additional programming, as it relies on an existing Stata command used for overdispersed count panel data. Including covariates to allow for regression models based in these distributions is straightforward.
title: Tower of digital arts
Creators: name: Mothwurf, Erik
Publisher: name: TU Wien
Year: 2019
Subjects: subject: Hochhaus
subject: Wien
subject: Mischnutzung
subject: Landmark
subject: Highrise
subject: Vienna
subject: Mixed Use
subject: Landmark

description: Die Donaumetropole Wien hat seit zehn Jahren den Ruf als lebenswerteste Stadt der Welt. Grund dafür sind neben den politischen, sozialen und ökonomischen Klima auch infrastrukturelle Voraussetzungen, genügend Freizeitangebote und gute Umweltbedingungen. Dieses Image unterstützt auch das stetige Wachstum der Bevölkerung, das sich auch in der Veränderung des Stadtbildes wiederspiegelt. International betrachtet gilt der Gebäudetypus Hochhaus und die daraus resultierende vertikale Entwicklung als ein Lösungsansatz zur Nachverdichtung. Diese Diplomarbeit behandelt die Entwicklung der Hochhaustypologie in Wien basierend auf den geltenden Normen und Richtlinien. Dies wird anhand eines Entwurfes, an der Unteren Donaustraße im 2. Bezirk, gegenüber dem Wiener Schwedenplatz, untersucht. Mit der Mischung von Wohnraum, Arbeitsplätzen, Bildungszentrum und Freizeitangeboten soll das facettenreiche Stadtgefüge im Gebäude konzeptuell aufgenommen werden. Trotz der Eingliederung in die Stadt soll der Turm als Landmark fungieren und im besonderen die Blickachse vom Praterstern zum Stephansdom noch zusätzlich verstärken - ohne diese zu beeinträchtigen.
description: For ten years the Danube metropolis Vienna has had the reputation as the city with the highest quality of living worldwide. This is due to the political, social and economic climate as well as infrastructural conditions, sufficient leisure facilities and good environmental conditions. However, with these conditions comes a steady growth of the population, which is also reflected in the transformation of the cityscape. From an international point of view, the building type skyscraper and the resulting vertical development are regarded as a solution for densification. This diploma thesis deals with the development of high-rise typology in Vienna based on the applicable standards and guidelines. This will be examined on the basis of a design at the Lower Danube Street in the 2nd district, opposite the Vienna Schwedenplatz. With the combination of living space, workplaces, education center and leisure facilities, the multifaceted city structure in the building is to be conceptualized. Despite the incorporation into the city, the tower is intended to function as a landmark and, in particular, to additionally strengthen the viewing axis from Praterstern to St. Stephen‘s Cathedral - without adversely affecting it.
Complete intersection singularities of splice type as universal abelian covers
Creators: name: Neumann, Walter D
name: Wahl, Jonathan
Publisher: name: arXiv
Year: 2004
Subjects: subject: Algebraic Geometry (math.AG)
subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 32S50, 14B05, 57M25, 57N10

description: It has long been known that every quasi-homogeneous normal complex surface singularity with Q-homology sphere link has universal abelian cover a Brieskorn complete intersection singularity. We describe a broad generalization: First, one has a class of complete intersection normal complex surface singularities called "splice type singularities", which generalize Brieskorn complete intersections. Second, these arise as universal abelian covers of a class of normal surface singularities with Q-homology sphere links, called "splice-quotient singularities". According to the Main Theorem, splice-quotients realize a large portion of the possible topologies of singularities with Q-homology sphere links. As quotients of complete intersections, they are necessarily Q-Gorenstein, and many Q-Gorenstein singularities with Q-homology sphere links are of this type. We conjecture that rational singularities and minimally elliptic singularities with Q-homology sphere links are splice-quotients. A recent preprint of T Okuma presents confirmation of this conjecture.
description: Published by Geometry and Topology at http://www.maths.warwick.ac.uk/gt/GTVol9/paper17.abs.html
Generation and partial characterization of a regulatory T cell phenotype following repeated in vivo treatement with the staphylococcal superantigen toxic shock syndrome toxin-1
Creators: name: Cameron, Scott
Publisher: name: University of British Columbia
Year: 2009

description: Toxic shock syndrome induced by superantigens such as TSST-1 is characterized by the production of lethal proinflammatory cytokines associated with a T helper 1 (T[sub H]I1) response including IL-2, IFN-y, TNF-α and IL-12. However, repeated exposure to superantigens appears to upregulate production of the anti-inflammatory cytokine IL-10 by CD4⁺ T[sub R]1 cells. T[sub R]1 cells have been implicated in suppression of autoimmune diseases, and their mechanism of differentiation and polarization is currently unclear. Therefore, the objective of this study was to determine if the staphylococcal superantigen TSST-1 was capable of inducing IL-10 producing T[sub R]1 cells, and to further characterize these cells based on their cytokine profile, surface marker expression and functional activity both in vitro and in vivo. Utilizing a protocol of repeated subcutaneous injections of 4μg TSST-1 in BALB/c mice, we observed a significant decrease in serum levels of IL-2 and IFN-y, while IL-10 levels were enhanced. The decrease in serum IL-2 and IFN-y levels observed in vivo following repeated TSST-1 stimulation were transferable to naive mice by adoptive transfer of 1x10⁷ CD4⁺ T cells intravenously from mice treated repeatedly with TSST-1. The observed in vivo suppression of IL-2 was dependent on IL-10 production, as blockade of the IL-10 receptor abrogated IL-2 suppression induced by adoptive CD4⁺ T cell transfer. Repeated in vivo treatment with TSST-1 was accompanied by an increase in both IL-10⁺IL-4⁺ and IL-10⁺IFN-y⁺ CD4⁺ splenocytes as well as IL-10⁺ single-positive cells as revealed by intracellular cytokine staining. Concurrently, there was a decrease in IL-2+ CD4+ splenocytes. TSST-1 treatment also induced a significant increase in intracellular CTLA-4 expression, and surface expression of CD25. CD4⁺ T cells from mice treated repeatedly with TSST-1 had significantly higher proportion of IL-10⁺CTLA-4⁺ double positive and CD4⁺CD25⁺CTLA-4⁺ triple positive cells compared to control mice. CD4⁺CD25⁺ splenocytes from mice treated repeatedly with TSST-1 were potent in their ability to induce elevated levels of IL-10 and IFN-y, and suppressed IL-2 production when mixed with naive splenocytes in a ratio as low as 1:20 and restimulated in vitro with TSST-1. Our investigations of regulatory T cells induced by repeated TSST-1 administration have added new insights with potential therapeutic applications in the fields of autoimmune disease, cancer resistance, and infectious disease pathogenesis.
An XSPEC model to explore spectral features from black-hole sources
Creators: name: Dovciak, M.
name: Karas, V.
name: Martocchia, A.
name: Matt, G.
name: Yaqoob, T.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We report on a new general relativistic computational model enhancing, in various respects, the capability of presently available tools for fitting spectra of X-ray sources. The new model is intended for spectral analysis of black-hole accretion discs. Our approach is flexible enough to allow easy modifications of intrinsic emissivity profiles. Axial symmetry is not assumed, although it can be imposed in order to reduce computational cost of data fitting. The main current application of our code is within the XSPEC data-fitting package, however, its applicability goes beyond that: the code can be compiled in a stand-alone mode, capable of examining time-variable spectral features and doing polarimetry of sources in the strong-gravity regime. Basic features of our approach are described in a separate paper (Dovciak, Karas & Yaqoob 2004). Here we illustrate some of its applications in more detail. We concentrate ourselves on various aspects of line emission and Compton reflection, including the current implementation of the lamp-post model as an example of a more complicated form of intrinsic emissivity.
description: in proceedings of the Workshop 'Processes in the vicinity of black holes and neutron stars' (Silesian University, Opava), in press, 35 pages
Functional analysis of the NUP98-Topoisomerase 1 (NUP98-TOP1) fusion gene in the pathogeneis of leukemia
Creators: name: Gurevich, Rhonna Michelle
Publisher: name: University of British Columbia
Year: 2009

description: Chromosomal rearrangements of the 1 lpl5 locus have been identified in hematopoietic malignancies, resulting in translocations involving the N-terminal portion of the nucleoporin gene NUP98. Sixteen different fusion partner genes have been identified for NUP98 and over half of these are homeobox transcription factors. By contrast, the NUP98 fusion partner in t(l 1;20) is Topoisomerase I (TOPI), a catalytic enzyme recognized for its key role in relaxing supercoiled DNA. We now show that retrovirally engineered expression of NUP98-TOP1 in murine bone marrow (BM) confers a potent in vitro growth advantage and a block in differentiation in hematopoietic precursors. In a murine BM transplantation model, NUP98- TOP1 expression led to a lethal, transplantable acute myeloid leukemia (AML). To ascertain if NUP98-TOP1 acts through a novel pathway, a panel of NUP98-TOP1 mutants was engineered and tested for their sub-cellular localization and their growth promoting effects. Neither the NUP98- 5' nor TOP1-3' portion of the fusion alone, nor a novel VP16-TOP1 fusion had any growth enhancing effects. Moreover, mutants lacking TOPI domains known to be involved in DNA binding were also unable to transform myeloid progenitors. The TOP1-3' mutant exhibited ubiquitous GFP expression, while NUP98-5' and the DNA binding mutants localized to distinct nuclear bodies. In-vitro mutagenesis was employed to mutate the TOPI active-site tyrosine (Y723F), a mutation known to abolish TOPI catalytic activity. Similar to NUP98- TOP1, NT-Y723F exhibited a nuclear localization, had an in vitro growth advantage and induced a lethal, transplantable AML, suggesting that NUP98-TOP1 induces its leukemogenic effects independent of TOPI catalytic, isomerase activity. As observed with expression of other translocation fusion products, the long latency of disease onset suggests the acquisition of additional genetic mutations. Two approaches were used to identify potential NUP98-TOP1 collaborating genes. We chose the strong candidate gene Meisl, as it has previously been shown to accelerate leukemia induced by several NUP98- HOX fusions. However, no evidence for collaboration between Meisl and NUP98-TOP1 was observed. Our second approach followed the serendipitous finding of NUP98-TOP1 retroviral integration into the ISCBP locus in a leukemic mouse. Strikingly, NUP98-TOP1 expression in ICSBP deficient bone marrow accelerated disease onset. The results of this thesis add to the recognition of NUP98 fusion genes as an important class of leukemic fusion proteins. These studies further demonstrate the complexity of the molecular pathways involved in leukemogenesis.
ÖKONOMISCHE BEWERTUNG EINES ALLEY-CROPPINGSYSTEMS ZUR NAHRUNGSMITTEL- UND ENERGIEHOLZPRODUKTION IN BRANDENBURG
Creators: name: Emmann, Carsten H.
name: Pannwitz, Christian
name: Schaper, Christian
name: Theuvsen, Ludwig
name: Emmann, Carsten H.
name: Pannwitz, Christian
name: Schaper, Christian
name: Theuvsen, Ludwig
Publisher: name: Unknown
Year: 2012
Subjects: subject: Agribusiness
subject: Crop Production/Industries
subject: Production Economics
subject: Productivity Analysis
subject: Klimawandel
subject: Agroforst
subject: Alley-Cropping-System
subject: Kurzumtrieb
subject: Brandenburg
subject: Kapitalwertmethode
subject: biologischer Mehrertrag
subject: Ausgleichszahlung
subject: Climate Change
subject: Agroforestry
subject: Alley Cropping System
subject: Short Rotation
subject: Net Present Value Method
subject: Biological Surplus
subject: Compensation

description: Im Zuge des Klimawandels gewinnen standortangepasste Landnutzungsverfahren an Bedeutung, die zumindest die regional zunehmenden Wind- und Wassererosionen reduzieren und gleichzeitig die Biodiversität auf der Fläche erhöhen können. Ein solches Verfahren können Alley-Cropping-Systeme darstellen, bei denen Kurzumtriebsstreifen in bestimmten Abständen in die Ackerflächen integriert werden. Bisherige Arbeiten haben zumeist nur Aussagen zur Wirtschaftlichkeit von bestehenden Alley-Cropping-Systemen im Ausland getroffen. Daher werden in diesem Beitrag unterschiedliche Formen von Alley-Cropping-Systemen mit Kurzumtriebsstreifen ökonomisch für den Großraum Brandenburg untersucht. Dazu werden diverse Szenarien und auch die Teilernte der Streifen zur kontinuierlichen Aufrechterhaltung der Windschutzwirkung berücksichtigt. Ein zentrales Ziel ist es, eine Aussage zu einem Schwellenwert des biologischen Mehrertrags der verbleibenden Ackerfläche zu treffen, damit dieses Agroforstsystem konkurrenzfähig zu einer Referenz-Ackerfläche sein kann. Die Ergebnisse sind im Bereich von ca. 3 bis 10 % mindestens benötigtem biologischem Mehrertrag ausgefallen. Zudem wird eine jährliche Ausgleichszahlung für die Anlage eines Alley-Cropping- Systems berechnet, welche zwischen ca. 230 bis 800 €/ha Kurzumtriebsstreifen liegen muss, um die ökonomischen Nachteile des Systems gegenüber einer Referenz-Ackerfläche auszugleichen.
title: Sport Hybrid Vienna
Creators: name: Almukhtar, Mohammed
Publisher: name: TU Wien
Year: 2019
Subjects: subject: urban
subject: sport
subject: sportarchitektur
subject: sporthalle
subject: urban
subject: sport
subject: sport architecture
subject: sport hall

description: Wien blickt auf eine lange Sportgeschichte zurück. Auch die so genannte “Stadtwildnis” am Gaudenzdorfer Knoten, unweit des Wienflusses und in direkter Lage an der Wienzeile war einst beliebter Treffpunkt sportliebender Wiener. Obwohl diese naturbelassene Grünfläche eine willkommene Abwechslung zum immer dichter werdenen Stadtgefüge zu sein scheint, sind seine Nutzungsmöglichkeiten für die Bewohner der Stadt, ausgenommen ihrer Hunde, praktisch nicht existent. Noch heute, und ich habe das Gefühl immer mehr, wird Aktivität in der Stadt wieder zu einem wichtigen Thema. Vom urbanen “Käfig” über zahlreiche öffentliche “Workout”-Zonen verteilt in der ganzen Stadt, suchen Menschen nach Möglichkeiten, dem Alltag zu entfliehen und sich körperlich zu betätigen. Diese Entwicklung war der Grund dafür, diese brache Fläche als meinen Bauplatz auszuwählen, um einen Mehrzweck-Sportbau zu entwerfen. Diese sollte den aktuellen Standards einer multifunktionalen und flexiblen Architektur gerecht werden, sich nachhaltigen Materialien bedienen und respektvoll mit der dort heimischen Vegetation umgehen, statt sie zu verdrängen. Das Gebäude soll der Öffentlichkeit zugänglich sein und neben seinen Sporthallen mietbare Räume bieten, die eine Vielzahl anderer Nutzungen erlauben. Entstehen soll ein ganzheitliches Projekt, vom Konzept über den Entwurf bis hin zu ausformulierten Details, um den Sportlern der Stadt Raum zu geben, oder besser, - um Sport “Stadt” finden zu lassen.
description: Vienna has a rich and long history in sports. Even the empty lot of land now called “Stadtwildnis” or “urban wilderness” on the Gaudenzdorfer crossroads, was one a beloved meeting point for athletes and sport enthusiasts from all over the city. Although this scruffy “wild” piece of meadow is a pleasant sight in todays ever-densifying metropolitan Vienna, its amenity values are, save for dog walking practically non-existent. As there is an ever increasing hunger for sports and athletic activities in the lives of modern day city dwellers, “sport cages” and “workout zones” throughout the city have become essential to escaping everyday life and train body and mind. This increase in demand was the main reason for me to take on the challenge of designing a multipurpose sports architecture, which not only pays respect to the existing green landscape by remaining largely underground, but also meets current standards of multi-functionality, flexibility and the application of sustainable materials. The building should be accessible to the main public and at the same time provide rentable offices and rooms for a variety of other functions. The aim of this project is to present a design that will provide more action space for the people of Vienna and help the city become more athletic.
Phase transitions for rock-scissors-paper game on different networks
Creators: name: Szolnoki, Attila
name: Szabo, Gyorgy
Publisher: name: arXiv
Year: 2004
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Monte Carlo simulations and dynamical mean-field approximations are performed to study the phase transitions in rock-scissors-paper game on different host networks. These graphs are originated from lattices by introducing quenched and annealed randomness simultaneously. In the resulting phase diagrams three different stationary states are identified for all structures. The comparison of results on different networks suggests that the value of clustering coefficient plays an irrelevant role in the emergence of a global oscillating phase. The critical behavior of phase transitions seems to be universal and can be described by the same exponents.
description: 4 pages, 4 figures, to be published in PRE
Additional file 4 of Open versus arthroscopic ankle arthrodesis: a systematic review and meta-analysis
Creators: name: Tsz Ngai Mok
name: Qiyu He
name: Soundarya Panneerselavam
name: Huajun Wang
name: Huige Hou
name: Xiaofei Zheng
name: Jinghua Pan
name: Li, Jieruo
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 4: Table S4. The Difference of Arthroscopic Arthrodesis.
ANALYSE UND BEWERTUNG INTERNATIONALER KLIMALABEL UND KLIMALABELPROGRAMME
Creators: name: Engel, Anna-Maria
name: Wegener, Jens Karl
name: Lange, Marco
name: Schaper, Christian
name: Engel, Anna-Maria
name: Wegener, Jens Karl
name: Lange, Marco
name: Schaper, Christian
Publisher: name: Unknown
Year: 2012
Subjects: subject: Environmental Economics and Policy
subject: Carbon Credit
subject: Klimalabel
subject: Kompensation
subject: CO2e-Emissionen
subject: Zertifizierung
subject: carbon label
subject: compensation
subject: greenhouse gas emissions
subject: certification

description: Im internationalen Wettbewerb gewinnt die Bilanzierung von CO2e-Emissionen in Unter-nehmen immer mehr an Bedeutung. Klimalabel bieten Unternehmen dabei die Möglichkeit, die Reduktion von CO2e-Emissionen entlang der Wertschöpfungskette ihrer Produkte an den Konsumenten zu kommunizieren. Durch den Kauf klimagelabelter Produkte können diese die unternehmerischen Klimaschutzaktivitäten unterstützen und nehmen somit aktiv am Klima-schutz teil. In den letzten Jahren hat sich eine Vielzahl von Klimalabeln und -programmen am Markt entwickelt. Da es noch keine international einheitlichen Methoden zur Analyse, Re-duktion und Kompensation von CO2e-Emissionen gibt, unterscheiden sich diese hinsichtlich der Anwendung der Standards, der Validierung, Verifizierung, Zertifizierung und der Carbon Credits. Ziel der vorliegenden Studie ist es, die verschiedenen am Markt befindlichen Klima-label und -programme anhand der genannten Unterschiede zu analysieren und zu vergleichen. Datengrundlage bildet eine Umfrage unter 19 internationalen Anbietern von Klimalabel und -programmen. Die Analyse zeigte, dass deutliche Unterschiede bei der Ausgestaltung der In-halte bzw. der Qualität der einzelnen Programme bestehen. Zur Erhöhung der Transparenz von Klimalabeln müssen international einheitliche Standards für die Bilanzierung und Kom-pensation von CO2e-Emissionen, deren Auszeichnung und Kontrolle entwickelt werden.
Additional file 3 of Cartilage-binding antibodies initiate joint inflammation and promote chronic erosive arthritis
Creators: name: Yanpeng Li
name: Dongmei Tong
name: Peibin Liang
name: Lönnblom, Erik
name: Viljanen, Johan
name: Bingze Xu
name: Kutty Selva Nandakumar
name: Holmdahl, Rikard
Publisher: name: figshare
Year: 2020
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 3 : Table S3. Showing disease incidence and maximum arthritis score with isotype control antibodies. Isotype controls: G11 + L243 + Hy2.15; Mice: 12-weeks-old males; 5-6 mice/group. B-LPS: before lipopolysaccharide injection; A-LPS: after lipopolysaccharide injection.
NATURSCHUTZFACHLICHE OPTIMIERUNG VON GRÜNLAND MIT HILFE DER FFH-MANAGEMENTPLANUNG IN SACHSEN
Creators: name: Lakner, Sebastian
name: Kleinknecht, Uta
name: Lakner, Sebastian
name: Kleinknecht, Uta
Publisher: name: Unknown
Year: 2012
Subjects: subject: Environmental Economics and Policy
subject: Farm Management
subject: Europäische Umweltpolitik
subject: Agrarumweltprogramme
subject: FFH–Managementplanung
subject: Entscheidung
subject: Naturschutz
subject: European environmental policy
subject: agri-environmental programs
subject: FFH-Managementplans
subject: decision
subject: nature-protection

description: Der vorliegende Beitrag analysiert die Umsetzung der FFH-Richtlinie durch Landwirte in Sachsen. Seit 2002 hat der Freistaat Sachsen 270 FFH-Gebiete an die Europäische Kommission gemeldet und führt in diesen Gebieten systematisch FFH-Managementplanungen durch mit dem Ziel die Naturschutzpraktiken auf den FFH-Flächen zu optimieren. Im Zuge der FFH-Managementplanung werden die Landwirte kontaktiert, um sie mit Hilfe von Beratungsgesprächen zur Optimierung ihrer Bewirtschaftungspraktiken zu motivieren. Der vorliegende Beitrag fasst die bisherigen Erfahrungen aus 17 FFH-Managementplänen in Sachsen zwischen 2003 und 2011 zusammen. Der Datensatz wurde mit Hilfe von Beratungsgesprächen gewonnen und besteht aus betriebsstrukturellen Informationen von 131 Betrieben und ökologische Informationen von 333 FFH-Flächen. Die Statistik zeigt, dass 63 % aller Betriebe bereit sind die Maßnahmen optimal umzusetzen, weitere 20 % zeigen sich offen, leicht angepasste Maßnahmen umzusetzen. Ein einfaches binäres Modell wird angewandt zur Bestimmung möglicher Einflussgrößen auf die Entscheidungen der Betriebe. Die Ergebnisse zeigen, dass die betriebliche Entscheidung für eine naturschutzfachliche Optimierung abhängig ist von der Viehbesatzdichte des Betriebes, jedoch nicht von Betriebsgröße oder dem Flächenumfang der entsprechenden FFH-Flächen auf dem Betrieb. Eine Umsetzung von FFHMaßnahmen ist auf Flächen mit speziellen Agrarumweltmaßnahmen wahrscheinlicher. Allerdings zeigen die Modellergebnisse und die Praxis, dass einige Agrarumweltmaßnahmen nicht immer zu den FFH-Flächen im höheren Erzgebirge passen. Insgesamt erscheint die Praxis der FFH-Managementpläne eine sinnvolle Ergänzung zu den Agrarumweltprogrammen, da dieser Planungsprozess, der in Sachsen von Betriebsbesuchen und Beratung begleitet wird, einen höheren Zielerreichungsgrad im Naturschutz ermöglicht und Landwirte zur Umsetzung von FFH-relevanten Naturschutzmaßnahmen motiviert.