cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Development and validation of carbodiimide-activated ELISA plate for quantifying IgG levels against Streptococcus pneumoniae capsular polysaccharides
Creators: name: Ramakrishnan, Shincy Mettingal
name: Mavupadi, Akhila Manheri
name: Govindan, Vandana
name: Nagaraj, Geetha
name: Ravikumar, Kadahalli Lingegowda
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Background: Conventional microtiter plates lack the surface strength needed for effective binding of pneumococcal polysaccharide antigens. This study tackles the limitation by altering the surface of polystyrene plates through carbodiimide activation under acidic pH conditions. Method: The microtiter plates were activated with carbodiimide coupling agents, N,N′-Dicyclohexylcarbodiimide (DCC) and N-Hydroxysuccinimide (NHS). They were subsequently coated with 13 pneumococcal antigens at a concentration of 5 μg/ml with a pH of 3.5. The IgG antibody titer was assessed utilizing the World Health Organization (WHO) ELISA protocol for 30 human serum samples. In addition, validation experiments were conducted to evaluate specificity and precision. Results: The modified plates exhibited two-times higher antibody titers compared to conventional plates across all 13 serotypes. Observations revealed elevated antibody levels, with geometric concentrations ranging between 0.96 μg/ml and 4.24 μg/ml. Conclusion: Carbodiimide activation and acidic pH modification of microtiter plates enhance sensitivity and specificity in detecting pneumococcal antibodies, critical for vaccination planning and immunity assessment. Accurate detection of pneumococcal antibodies is vital for evaluating individual immunity and designing vaccination strategies, highlighting the need for a dependable method to assess specific immunity to pneumococcal polysaccharide antigens. Despite World Health Organization guidelines, it is essential to adapt methods to local settings and resources when measuring serotype-specific pneumococcal antibodies. The WHO's commonly recommended polystyrene microtiter plates are expensive, prompting the exploration of alternative methods. A simple, sensitive method involves covalently attaching polysaccharide antigens to polystyrene surfaces at pH 3.5, ensuring robust binding for precise assessment. Modified ELISA plates show two- to four-times higher antibody titers and outperform conventional plates, enhancing pneumococcal antibody detection reliability.
Acyclovir-induced neurotoxicity in an immunocompromised patient
Creators: name: Walston, Bobbi Jo
name: Marks, Daniel
name: De La Paz, Andrew
Publisher: name: SAGE Publications Ltd
Year: 2020

description: This is a case report of a 75-year-old immunocompromised male who developed encephalopathy while undergoing treatment for disseminated herpes zoster with peripheral nerve involvement. While his initial presentation involved primarily profound lower extremity weakness, he developed progressive confusion to the point of obtundation only after initiation of standard therapy with intravenous acyclovir. The evaluation of his altered mental status was largely unremarkable. It was only after his acyclovir was discontinued that his symptoms resolved and he returned to his baseline mental status. His presentation was most consistent with acyclovir-induced neurotoxicity, which can present in patients with renal impairment and those who are immunocompromised.
Minimal Length Effects on Entanglement Entropy of Spherically Symmetric Black Holes in Brick Wall Model
Creators: name: Wang, Peng
name: Yang, Haitang
name: Ying, Shuxuan
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We compute the black hole horizon entanglement entropy for a massless scalar field in the brick wall model by incorporating the minimal length. Taking the minimal length effects on the occupation number $n(ω,l)$ and the Hawking temperature into consideration, we obtain the leading UV divergent term and the subleading logarithmic term in the entropy. The leading divergent term scales with the horizon area. The subleading logarithmic term is the same as that in the usual brick wall model without the minimal length.
description: 15 pages. arXiv admin note: substantial text overlap with arXiv:1501.06025
Boxicity and topological invariants
Creators: name: Esperet, Louis
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: The boxicity of a graph $G=(V,E)$ is the smallest integer $k$ for which there exist $k$ interval graphs $G_i=(V,E_i)$, $1 \le i \le k$, such that $E=E_1 \cap \cdots \cap E_k$. In the first part of this note, we prove that every graph on $m$ edges has boxicity $O(\sqrt{m \log m})$, which is asymptotically best possible. We use this result to study the connection between the boxicity of graphs and their Colin de Verdière invariant, which share many similarities. Known results concerning the two parameters suggest that for any graph $G$, the boxicity of $G$ is at most the Colin de Verdière invariant of $G$, denoted by $μ(G)$. We observe that every graph $G$ has boxicity $O(μ(G)^4(\log μ(G))^2)$, while there are graphs $G$ with boxicity $Ω(μ(G)\sqrt{\log μ(G)})$. In the second part of this note, we focus on graphs embeddable on a surface of Euler genus $g$. We prove that these graphs have boxicity $O(\sqrt{g}\log g)$, while some of these graphs have boxicity $Ω(\sqrt{g \log g})$. This improves the previously best known upper and lower bounds. These results directly imply a nearly optimal bound on the dimension of the adjacency poset of graphs on surfaces.
description: 6 pages
Adopting FAIR principles for long-term agricultural experiments
Creators: name: Ostler, Richard
Publisher: name: F1000 Research Limited
Year: 2020

description: This presentation will focus on our approach to FAIRifying and publishing this data and the data management and cultural challenges this has raised. The presentation will conclude with future capacity development training in collaboration with the GLTEN and the University of Sokoine, Tanzania, to improve data management skills and access to data across the global long-term agricultural experiments community.
Stability of time-dependent Navier-Stokes flow and algebraic energy decay
Creators: name: Hishida, Toshiaki
name: Schonbek, Maria Elena
Publisher: name: arXiv
Year: 2014
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35Q30

description: Let $V$ be a given time-dependent Navier-Stokes flow of an incompressible viscous fluid in the whole space ($n=3,4$). Assume such $V$ to be small in $L^\infty(0,\infty; L^{n,\infty})$, where $L^{n,\infty}$ denotes the weak-$L^n$ space. The energy stability of this basic flow $V$ with respect to any initial disturbance in $L^2_σ$ has been established by Karch, Pilarczyk and Schonbek. In this paper we study, under reasonable conditions, the algebraic rates of energy decay of disturbances as $t\to\infty$.
description: 43 pages
(502675) Ralph Watson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Building global infrastructure for interoperability across the agriculture industry: AgGateway and its Agrisemantics Working Group
Creators: name: R. Andres Ferreyra
Publisher: name: F1000 Research Limited
Year: 2020

description: AgGateway is a global nonprofit industry association with a membership of approximately 200 companies. The purpose of AgGateway is to enable digital agriculture by promoting the implementation of data exchange standards, both in supply chain and field operations domains. Examples of supply-chain standards include the Ag eStandards (for communication among manufacturers, distributors, and retailers) and AgXML (for grain contracts, transport, settlements, weights, and grades). Examples of standards implemented in the field operations space include ISO 11783 and ISO 19156.
(Re)writing history: Examining the cultural work of the obituary and journalists’ construction of a former president’s legacy
Creators: name: Adams, Kirsten
Publisher: name: SAGE Publications Ltd
Year: 2020

description: This study provides an empirical and analytical look at how obituaries, as a relatively unexplored form of journalism, illuminate the long-term and conscious cultural work that journalists do. Through in-depth qualitative interviews with the elite political journalists who wrote and produced news obituaries for former US President George H. W. Bush, I offer a framework for understanding how journalists rewrite, and ‘recast’, drafts of history and Bush’s legacy. Results show how the obituary form, and the process involved in its creation, functions as a unique opportunity for political journalists – who have, perhaps for decades, covered a politician according to the norms of the profession – to now write about him in a way that they are keenly aware will become part of history. This research illustrates how the role of political or ‘hard-news’ journalism shifts when reporters write their final story about a president.
Plasma Processing of Large Curved Surfaces for SRF Cavity Modification
Creators: name: Upadhyay, J.
name: Im, Do
name: Popović, S.
name: Valente-Feliciano, A. -M.
name: Phillips, L.
name: Vušković, L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: Plasma based surface modification of niobium is a promising alternative to wet etching of superconducting radio frequency (SRF) cavities. The development of the technology based on Cl2/Ar plasma etching has to address several crucial parameters which influence the etching rate and surface roughness, and eventually, determine cavity performance. This includes dependence of the process on the frequency of the RF generator, gas pressure, power level, the driven (inner) electrode configuration, and the chlorine concentration in the gas mixture during plasma processing. To demonstrate surface layer removal in the asymmetric non-planar geometry, we are using a simple cylindrical cavity with 8 ports symmetrically distributed over the cylinder. The ports are used for diagnosing the plasma parameters and as holders for the samples to be etched. The etching rate is highly correlated with the shape of the inner electrode, radio-frequency (RF) circuit elements, chlorine concentration in the Cl2/Ar gas mixtures, residence time of reactive species and temperature of the cavity. Using cylindrical electrodes with variable radius, large-surface ring-shaped samples and d.c. bias implementation in the external circuit we have demonstrated substantial average etching rates and outlined the possibility to optimize plasma properties with respect to maximum surface processing effect.
An overview of data management, processing, and analytical tools and services
Creators: name: Medha  Devare
Publisher: name: F1000 Research Limited
Year: 2020

description: COVID-19 has shown that Findable, Accessible, Interoperable, and Reusable (FAIR) data assets are the building blocks for data-driven, collaborative and agile crisis response and resilience over the long term. Responding rapidly and effectively to disruptions in agriculture similarly hinges around enabling discovery of and access to publications, data, and data products that are interpretable and interoperable – for humans and machines. This is also a critical piece of the strategy for enhancing the impact of research and development in the agricultural domain in general, and for catalyzing innovation in our efforts to fuel a “translational agriculture” revolution. There is a strong model in the biomedical sector to achieve seamless discoverability, interlinkages and interoperability across their data resources. Guided by this, CGIAR’s Big Data Platform has developed and/or curated several openly available solutions to enable good data management practices leading to the generation of open and FAIR data assets, along with tools to access them, and an analytical environment and other services to more seamlessly and ethically process and derive insight from data. This talk will provide an overview of these as a response to a potential data gap in this moment of crisis coupled with an increased recognition of the importance of open, human and machine interoperable data through the systematic use of these tools and services.
(502573) Henry Bennett
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Endothelium function dependence of acute changes in pulse wave velocity and flow-mediated slowing
Creators: name: Credeur, D.P.
name: Fryer, S.
name: Stone, K.
name: Blackwell, J.
name: Stoner, L.
name: Zieff, G.
name: Paterson, C.
name: Diana, J.
Publisher: name: SAGE Publications Ltd
Year: 2020

description: Flow-mediated slowing (FMS), defined as the minimum pulse wave velocity (PWVmin) during reactive hyperemia, is potentially a simple, user-objective test for examining endothelial function. The purpose of the current study was to determine the effects of a known endothelial dysfunction protocol on arm PWV and PWVmin. Complete data were successfully collected in 22 out of 23 healthy adults (23.8 years [SD 4.1], 16 F, 22.8 kg/m2 [SD 2.8]). Local endothelial dysfunction was induced by increasing retrograde shear stress in the upper arm, through inflation of a distal (forearm) tourniquet to 75 mmHg, for 30 min. Pre- and post-endothelial dysfunction, PWV was measured followed by simultaneous assessment of PWVmin and flow-mediated dilation (FMD). PWV was measured between the upper arm and wrist using an oscillometric device, and brachial FMD using ultrasound. FMD (%) and PWVmin (m/s) were calculated as the maximum increase in diameter and minimum PWV during reactive hyperemia, respectively. Endothelial dysfunction resulted in a large effect size (ES) decrease in FMD (∆ = −3.10%; 95% CI: –4.15, –2.05; ES = −1.3), and a moderate increase in PWV (∆ = 0.38 m/s; 95% CI: 0.07, 0.69; ES = 0.5) and PWVmin (∆ = 0.16 m/s; 95% CI: 0.05, 0.28; ES = 0.6). There was a large intra-individual (pre- vs post-endothelial dysfunction) association between FMD and PWVmin (r = −0.61; 95% CI: –0.82, –0.24). In conclusion, acute change in PWV and PWVmin are at least partially driven by changes in endothelial function.
Effects of threat sensitivity and issue concern on candidate preference
Creators: name: Smith, Brianna A.
name: Kim, Hannah
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: Evolutionary Biology
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Computational Biology

description: There is extensive debate in the literature over the link between threat and political attitudes – while some find evidence that threat and threat sensitivity lead to political conservatism, others find that the effect of threat is more contextual. We contribute to this debate by theorizing that the link between threat and politics is based on both individual differences and political rhetoric. First, sensitivity about personal threats predicts greater concern about political threats as well. This issue concern may in turn be directed toward either conservatism or liberalism through political rhetoric and elite positioning. Using one observational and one experimental survey of American adults conducted in 2018 and 2023, we find consistent evidence that personal threat sensitivity increases issue concern regardless of the specific issue or its partisan ownership, and independent of partisanship or ideology. This increased issue concern does not produce a uniformly conservative shift – rather, an increase in concern about “Republican” issues leads to greater preference for Republican candidates, and vice versa for Democrats. The relationship between threat sensitivity and political attitudes is thus best understood as a contextual one.
Interplay of relativistic and nonrelativistic transport in atomically precise segmented graphene nanoribbons
Creators: name: Yannouleas, Constantine
name: Romanovsky, Igor
name: Landman, Uzi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Graphene's isolation launched explorations of fundamental relativistic physics originating from the planar honeycomb lattice arrangement of the carbon atoms, and of potential technological applications in nanoscale electronics. Bottom-up fabricated atomically-precise segmented graphene nanoribbons, SGNRs, open avenues for studies of electrical transport, coherence, and interference effects in metallic, semiconducting, and mixed GNRs, with different edge terminations. Conceptual and practical understanding of electric transport through SGNRs is gained through nonequilibrium Green's function (NEGF) conductance calculations and a Dirac continuum model that absorbs the valence-to-conductance energy gaps as position-dependent masses, including topological-in-origin mass-barriers at the contacts between segments. The continuum model reproduces the NEGF results, including optical Dirac Fabry-Perot (FP) equidistant oscillations for massless relativistic carriers in metallic armchair SGNRs, and an unequally-spaced FP pattern for mixed armchair-zigzag SGNRs where carriers transit from a relativistic (armchair) to a nonrelativistic (zigzag) regime. This provides a unifying framework for analysis of coherent transport phenomena and interpretation of forthcoming experiments in SGNRs.
description: 12 pages, 6 figures. For related papers, see http://www.prism.gatech.edu/~ph274cy/
Evolution in Local Traffic Impact Assessment Practices
Creators: name: Leimenstoll, W.
name: McDonald, N.C.
name: Combs, T.S.
Publisher: name: SAGE Publications Inc.
Year: 2020

description: This study evaluates the state of traffic impact assessment (TIA) practice at the local level in North Carolina and the Washington D.C. metro area. Using semistructured interviews and surveys of staff involved in the development review process in sixty-three jurisdictions, we conclude that the conventional, automobile-oriented approach to TIA remains the dominant model in the study area, although our research reveals efforts to modify practice. Content analysis of interviews in thirty-six jurisdictions indicates lack of information and technical capacity are substantial barriers to change, highlighting areas in which planning education and research could better support practice.
(502600) John Cook
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Hypoxia induces de novo formation of cerebral collaterals and lessens the severity of ischemic stroke
Creators: name: Aghajanian, A.
name: Rzechorzek, W.
name: Zhang, H.
name: Faber, J.E.
Publisher: name: SAGE Publications Ltd
Year: 2020

description: Pial collaterals provide protection in stroke. Evidence suggests their formation late during gestation (collaterogenesis) is driven by reduced oxygen levels in the cerebral watersheds. The purpose of this study was to determine if collaterogenesis can be re-activated in the adult to induce formation of additional collaterals (“neo-collateral formation”, NCF). Mice were gradually acclimated to reduced inspired oxygen (FIO2) and maintained at 12, 10, 8.5 or 7% for two-to-eight weeks. Hypoxemia induced “dose”-dependent NCF and remodeling of native collaterals, and decreased infarct volume after permanent MCA occlusion. In contrast, no formation occurred of addition collateral-like intra-tree anastomoses, PComs, or branches within the MCA tree. Hypoxic NCF, remodeling and infarct protection were durable, i.e. retained for at least six weeks after return to normoxia. Hypoxia increased expression of Hif2α, Vegfa, Rabep2, Angpt2, Tie2 and Cxcr4. Neo-collateral formation was abolished in mice lacking Rabep2, a novel gene involved in VEGFA→Flk1 signaling and required for formation of collaterals during development, and inhibited by knockdown of Vegfa, Flk1 and Cxcr4. Rabep2-dependent NCF was also induced by permanent MCA occlusion. This is the first report that hypoxia induces new pial collaterals to form. Hypoxia- and occlusion-induced neo-collateral formation provide models to study collaterogenesis in the adult.
(502326) Jane Purdy
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Experimental mathematics meets gravitational self-force
Creators: name: Johnson-McDaniel, Nathan K.
name: Shah, Abhay G.
name: Whiting, Bernard F.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: It is now possible to compute linear in mass-ratio terms in the post-Newtonian (PN) expansion for compact binaries to very high orders using black hole perturbation theory applied to various invariants. For instance, a computation of the redshift invariant of a point particle in a circular orbit about a black hole in linear perturbation theory gives the linear-in-mass-ratio portion of the binding energy of a circular binary with arbitrary mass ratio. This binding energy, in turn, encodes the system's conservative dynamics. We give a method for extracting the analytic forms of these PN coefficients from high-accuracy numerical data using experimental mathematics techniques, notably an integer relation algorithm. Such methods should be particularly important when the calculations progress to the considerably more difficult case of perturbations of the Kerr metric. As an example, we apply this method to the redshift invariant in Schwarzschild. Here we obtain analytic coefficients to 12.5PN, and higher-order terms in mixed analytic-numerical form to 21.5PN, including analytic forms for the complete 13.5PN coefficient, and all the logarithmic terms at 13PN. At these high orders, an individual coefficient can have over 30 terms, including a wide variety of transcendental numbers, when written out in full. We are still able to obtain analytic forms for such coefficients from the numerical data through a careful study of the structure of the expansion. The structure we find also allows us to predict certain "leading logarithm"-type contributions to all orders. The additional terms in the expansion we obtain improve the accuracy of the PN series for the redshift observable, even in the very strong-field regime inside the innermost stable circular orbit, particularly when combined with exponential resummation.
description: 25 pages, 3 figures; version accepted by PRD, including various small additions and corrections
Toward a Framework for Public Accountability in Education Reform
Creators: name: Polikoff, M.S.
name: Hutt, E.
Publisher: name: SAGE Publications Inc.
Year: 2020

description: Public accountability through information disclosure is a pillar of modern education reform efforts. Despite the ubiquity of this approach, we argue that public accountability in education is undertheorized and often predictably unlikely to achieve its intended policy goals. Drawing on examples from an equity-oriented court case in California and the literatures on democratic engagement and parent use of school performance data, we propose a framework for thinking about the design of public accountability systems in education. The framework could provide guidance for policymakers considering new efforts at improving schools through the production and dissemination of educational data.
(502572) Dorothy Bennett
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Investigating mechanisms of resistance to serdemetan in neuroblastoma
Creators: name: Laing, Eden Alexandra
Publisher: name: University of Kent
Year: 2023

description: Neuroblastoma is the most abundant extra-cranial tumor in pediatric patients. Though outlook for low-risk patients has significantly improved in the last decade, those classified as high-risk face uncertain outcomes. Drug-resistance is the principal issue, causing relapse and death for approximately 50% of high-risk patients. MDM2 inhibitors are under investigation as drug candidates for neuroblastoma. They induce p53 anticarcinogenic activity by disrupting the negative feedback interaction between MDM2 and p53, and are known to induce TP53 mutations as a resistance mechanism. Serdemetan, introduced as an MDM2 inhibitor, is one such drug where the likelihood of resistance development is high. Therefore it serves as a useful model for studying resistance formation. Investigation into how resistance develops is critical to circumnavigating it and improving high-risk patient survival rates. To address this, exome data from serdemetan-adapted sublines of the neuroblastoma cell line UKF-NB-3 were compared to those derived from the parental UKF-NB-3 cell line. Critical variants and pathways effected were identified and the degree of similarity between the sublines was established. Sublines containing TP53 null mutations were found to contain a high degree of similarity in variants acquired after serdemetan treatment, while those wild type for this gene were more similar. Three pathways were determined to be critically mutated, with alterations likely leading to resistance formation: 1) the cholesterol transport pathway, 2) the p53 signaling pathway, and 3) the xenobiotic clearance pathway. The involvement of multiple pathways indicates that there is not a one-size-fits-all mechanism of action through which resistance to serdemetan develops. However, mutations to the cholesterol transport pathway were deemed to be the most crucial to resistance formation, as the presence of these alone were enough to induce it. These findings implicate the cholesterol transport pathway in serdemetan's mechanism of action, confirming its' mechanisms exist beyond just modulation of MDM2 activity.
title: Special Focus on EU Strategic Autonomy and Technological Sovereignty: An Introduction
Creators: name: Beaucillon, Charlotte
name: Poli, Sara
Publisher: name: European Papers (www.europeanpapers.eu)
Year: 2023
Subjects: subject: Strategic Autonomy
subject: Technological Sovereignty
subject: Digital Sovereignty
subject: Defence
subject: Space
subject: Foreign Direct Investments

description: European Papers - A Journal on Law and Integration, 2023 8(2), 411-416
description: European Forum Insight of 27 July 2023
description: I. EU strategic autonomy and technological sovereignty: an overview. - II. Mapping the sectors of EU strategic autonomy and technological sovereignty. - III. Identifying cross-cutting instruments to guarantee EU’s strategic autonomy. - IV. Structure and Contents of the Special Focus
description: This Special Focus aims at reflecting on the concepts of European technological sovereignty (ETS) and European strategic autonomy (ESA). Taking a legal perspective, it gathers the Insights of a group of scholars on highly debated issues such as the EU’s strategic autonomy, technical and digital sovereignty.
Cochlear Implantation in Cases of Asymmetric Hearing Loss: Subjective Benefit, Word Recognition, and Spatial Hearing
Creators: name: Richter, M.E.
name: Thompson, N.J.
name: Canfarotta, M.W.
name: Deres, E.J.
name: Pillsbury, H.C.
name: Rooth, M.A.
name: McCarthy, S.A.
name: Bucker, A.L.
name: Dillon, M.T.
name: Brown, K.D.
name: Buss, E.
name: O'Connell, B.P.
name: King, E.R.
Publisher: name: SAGE Publications Inc.
Year: 2020

description: A prospective clinical trial evaluated the effectiveness of cochlear implantation in adults with asymmetric hearing loss (AHL). Twenty subjects with mild-to-moderate hearing loss in the better ear and moderate-to-profound hearing loss in the poorer ear underwent cochlear implantation of the poorer hearing ear. Subjects were evaluated preoperatively and at 1, 3, 6, 9, and 12 months post-activation. Preoperative performance was evaluated unaided, with traditional hearing aids (HAs) or with a bone-conduction HA. Post-activation performance was evaluated with the cochlear implant (CI) alone or in combination with a contralateral HA (bimodal). Test measures included subjective benefit, word recognition, and spatial hearing (i.e., localization and masked sentence recognition). Significant subjective benefit was reported as early as the 1-month interval, indicating better performance with the CI compared with the preferred preoperative condition. Aided word recognition with the CI alone was significantly improved at the 1-month interval compared with preoperative performance with an HA and continued to improve through the 12-month interval. Subjects demonstrated early, significant improvements in the bimodal condition on the spatial hearing tasks compared with baseline preoperative performance tested unaided. The magnitude of the benefit was reduced for subjects with AHL when compared with published data on CI users with normal hearing in the contralateral ear; this finding may reflect significant differences in age at implantation and hearing sensitivity across cohorts.
Etching Mechanism of Niobium in Coaxial Ar/Cl2 RF Plasma
Creators: name: Upadhyay, J.
name: Im, Do
name: Popović, S.
name: Valente-Feliciano, A. -M.
name: Phillips, L.
name: Vušković, L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: The understanding of the Ar/Cl2 plasma etching mechanism is crucial for the desired modification of inner surface of the three dimensional niobium (Nb) superconductive radio frequency cavities. Uniform mass removal in cylindrical shaped structures is a challenging task, because the etch rate varies along the direction of gas flow. The study is performed in the asymmetric coaxial RF discharge with two identical Nb rings acting as a part of the outer electrode. The dependence of etch rate uniformity on pressure, RF power, DC bias, Cl2 concentration, diameter of the inner electrode, temperature of the outer cylinder and position of the samples in the structure is determined. To understand the plasma etching mechanisms, we have studied several factors that have important influence on the etch rate and uniformity, which include the plasma sheath potential, Nb surface temperature, and the gas flow rate.
The Binaural Interaction Component of the Auditory Brainstem Response Under Precedence Effect Conditions
Creators: name: Grose, J.H.
name: Dean, K.
Publisher: name: SAGE Publications Ltd
Year: 2020

description: The purpose of this study was to measure the binaural interaction component (BIC) derived from click-evoked auditory brainstem responses (ABRs) using stimuli configured to elicit the Precedence Effect. The hypothesis was that the contribution of binaural processing to echo suppression can be evidenced by a diminished or absent BIC associated with the echo. Ten normal-hearing young adults provided ABRs generated by sequences of click pairs. Results showed that BICs elicited by diotic clicks in isolation were obliterated when those diotic clicks were preceded by a click pair having an interaural time difference of 400 µs and where the interclick interval was 8.4 ms. The presence of the leading click pair increased the latency of the ABR generated by the lagging diotic click pair but did not decrease its amplitude. The results were interpreted as indicating a contribution of binaural processing at the level of the brainstem to echo suppression, at least for the conditions tested here.
(502599) George Frederick Ayre
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Düsseldorf, Siegen, Wuppertal: Forschungsdatenmanagement im Kooperationsverbund
Creators: name: Bohn, Henning
name: Rathmann, Torsten
name: Schäffer, Christian
Publisher: name: University of Wuppertal
Year: 2020

description: Post-print version of a journal article that was first published in: ProLibris 2018, 23(2), 58-59. Secondary publication with friendly permission of the publisher.
description: Postprint-Version eines Zeitschriftenaufsatzes, der zuerst veröffentlicht wurde in: ProLibris 2018, 23(2), 58-59. Zweitveröffentlichung mit freundlicher Genehmigung der Herausgeber.
description: ProLibris 2018, 23(2), 58-59
Iterative phase contrast CT reconstruction with novel tomographic operator and data-driven prior.
Creators: name: Van Gogh, Stefano
name: Mukherjee, Subhadip
name: Xu, Jinqiu
name: Wang, Zhentian
name: Rawlik, Michał
name: Varga, Zsuzsanna
name: Alaifari, Rima
name: Schönlieb, Carola-Bibiane
name: Stampanoni, Marco
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: subject: Research Article
subject: Physical sciences
subject: FOS: Physical sciences
subject: Research and analysis methods
subject: Biology and life sciences
subject: Medicine and health sciences
subject: Computer and information sciences
subject: FOS: Computer and information sciences

description: Funder: ETH Doc.Mobility Fellowship
description: Funder: Promedica Stiftung; funder-id: http://dx.doi.org/10.13039/501100008307
description: Funder: Swisslos Lottery Fund of canton Aargau
description: Breast cancer remains the most prevalent malignancy in women in many countries around the world, thus calling for better imaging technologies to improve screening and diagnosis. Grating interferometry (GI)-based phase contrast X-ray CT is a promising technique which could make the transition to clinical practice and improve breast cancer diagnosis by combining the high three-dimensional resolution of conventional CT with higher soft-tissue contrast. Unfortunately though, obtaining high-quality images is challenging. Grating fabrication defects and photon starvation lead to high noise amplitudes in the measured data. Moreover, the highly ill-conditioned differential nature of the GI-CT forward operator renders the inversion from corrupted data even more cumbersome. In this paper, we propose a novel regularized iterative reconstruction algorithm with an improved tomographic operator and a powerful data-driven regularizer to tackle this challenging inverse problem. Our algorithm combines the L-BFGS optimization scheme with a data-driven prior parameterized by a deep neural network. Importantly, we propose a novel regularization strategy to ensure that the trained network is non-expansive, which is critical for the convergence and stability analysis we provide. We empirically show that the proposed method achieves high quality images, both on simulated data as well as on real measurements.
Investing the Time: Group Differences in Cultural Capital Development Among U.S. Adolescents
Creators: name: Hwang, Karam
Publisher: name: SAGE Publications Inc.
Year: 2020

description: This study examines the extent of class and racial inequalities in cultural capital development among recent adolescent cohorts in the United States. Informed by several decades of cultural capital research, I compare participation in four dimensions of cultural capital proposed by prior scholarship—highbrow consumption, omnivorous consumption, technical capacity, and social competence—by using nationally representative time-diary data to test for group differences in time-use patterns. Time investment has been long theorized but seldom tested as the means through which individuals develop cultural capital. Activities associated with technical capacity appear to have the greatest potential as the bases for both class and racial exclusions, as group differences are evident in both the prevalence and duration of participation. Smaller race and class differences are evident for omnivorous consumption, and low participation in highbrow activities is evident across all groups. Distinct patterns of time-use among Asian American adolescents suggest they are simultaneously advantaged and disadvantaged in their cultural capital acquisition, speaking to debates regarding their relative status in the United States.
Labour Agency and Transnational Environmental Regulation - A Study of the Relevance of Global Framework Agreements
Creators: name: Guedes, Coralie
Publisher: name: University of Westminster
Year: 2023

description: This thesis analyses how the growing role of labour actors in processes of environmental regulation is reflected in and influenced by the negotiation and implementation of global framework agreements that include environmental provisions (EGFAs). Departing from previous studies of GFAs, the thesis provides a thoroughly contextualised thematic analysis of GFAs focussed on environmental issues, using a trans-disciplinary approach, combining legal and sociological perspectives through the prism of labour environmentalism. It asks how the inclusion of environmental provisions is connected to other processes of environmental regulation, including through the agency of labour actors, mainly unions, at different scales. Data collection involves the creation of a database of EGFAs consisting of statistical information and an extensive account of their content, and an analysis of three case studies, chosen from the database and informed by semi-structured interviews and focus groups carried out with union and management representatives at various scales. Relying on a bourdieusian analytical framework articulated around the ‘thinking tools’ of field, habitus and capital, the thesis makes a methodological contribution by weaving together the analysis of the content of EGFAs and the cases. Ultimately, the thesis provides an empirical, analytical and theoretical understanding of practices of negotiation and implementation of EGFAs. Emphasising that context matters, it shows that these practices are connected to political, legal and organisational regulatory processes involving labour actors at multiple scales. The agency of labour actors in these processes relates to their capacity to connect to multi-scalar and multi-directional networks through the articulation of abstract rules, standards, notions, etc. with concrete situations. Focussing on processes of environmental regulation, prevalent approaches were found to be informed by different conceptions of the relationship between labour and nature and to translate into various understandings of the role of EGFAs, ranging from endorsement of companies’ CSR policies and practices to instruments of social and environmental justice.
Manipulating electronic states at oxide interfaces using focused micro X-rays from standard lab-sources
Creators: name: Poccia, Nicola
name: Ricci, Alessandro
name: Coneri, Francesco
name: Stehno, Martin
name: Campi, Gaetano
name: Demitri, Nicola
name: Bais, Giorgio
name: Wang, X. Renshaw
name: Hilgenkamp, H.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Recently, x-ray illumination, using synchrotron radiation, has been used to manipulate defects, stimulate self-organization and to probe their structure. Here we explore a method of defect-engineering low-dimensional systems using focused laboratory-scale X-ray sources. We demonstrate an irreversible change in the conducting properties of the 2-dimensional electron gas at the interface between the complex oxide materials LaAlO3 and SrTiO3 by X-ray irradiation. The electrical resistance is monitored during exposure as the irradiated regions are driven into a high resistance state. Our results suggest attention shall be paid on electronic structure modification in X-ray spectroscopic studies and highlight large-area defect manipulation and direct device patterning as possible new fields of application for focused laboratory X-ray sources.
description: 12 pages, 4 figures
Sensitization of agricultural stakeholders on the need and benefits of data for equal development: open data day – experience from Nigeria
Creators: name: Ifejika, Philip I.
Publisher: name: F1000 Research Limited
Year: 2020

description: The presentation is to share the experience of open data day events on sensitization of agricultural stakeholders on the need and benefits of data for equal development. Highlights will be on principles supporting open data, model for data-driven services related farmer profiles, data capturing tools, farmer Profiling, benefits of data ( individual, farmers group, and organisations) and a sample of Zenvus SMART Tech. On data for equal development highlighted issues of gender equality and equity, resource allocation, planning and development business models. Finally, is an action plan through training to reduce data illiteracy, setting database, and data infrastructure investment.
Vorhersagemuster für Zeitschriften in Alma Hilfestellungen aus der Praxis
Creators: name: Frech, Mischa
name: Strub, Maeva
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2023
Subjects: subject: Katalogisierung
subject: Zeitschriften
subject: ALMA
subject: 020 - Bibliotheks- und Informationswissenschaft

description: Das vorliegende Dokument erklärt die Erfassung und Verwaltung von Zeitschriftenabonnements im Netzwerk von SLSP – Swiss Library Service Plattform. Verwaltet werden die bibliografischen Daten von SLSP nach dem Regelwerk RDA im Bibliothekssystem «ALMA» von ExLibris. Die Arbeit fokussiert sich auf die sog. «Vorhersagemuster» und hierbei insb. auf das MARC21-Feld 853 im Bestandes-Satz.
Tracking the incidence and risk factors for SARS-CoV-2 infection using historical maternal booking serum samples.
Creators: name: Mullins, Edward
name: McCabe, Ruth
name: Bird, Sheila M
name: Randell, Paul
name: Pond, Marcus J
name: Regan, Lesley
name: Parker, Eleanor
name: McClure, Myra
name: Donnelly, Christl A
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Research Article
Biology and life sciences
Medicine and health sciences
People and places

description: Funder: Community Jameel and the Imperial President’s Excellence Fund
description: Funder: NIHR Academic Clinical Lecturer
description: Funder: NIHR CV220-111
description: Funder: NIHR Imperial College Biomedical Research Centre
description: The early transmission dynamics of SARS-CoV-2 in the UK are unknown but their investigation is critical to aid future pandemic planning. We tested over 11,000 anonymised, stored historic antenatal serum samples, given at two north-west London NHS trusts in 2019 and 2020, for total antibody to SARS-CoV-2 receptor binding domain (anti-RBD). Estimated prevalence of seroreactivity increased from 1% prior to mid-February 2020 to 17% in September 2020. Our results show higher prevalence of seroreactivity to SARS-CoV-2 in younger, non-white ethnicity, and more deprived groups. We found no significant interaction between the effects of ethnicity and deprivation. Derived from prevalence, the estimated incidence of seroreactivity reflects the trends observed in daily hospitalisations and deaths in London that followed 10 and 13 days later, respectively. We quantified community transmission of SARS-CoV-2 in London, which peaked in late March / early April 2020 with no evidence of community transmission until after January 2020. Our study was not able to determine the date of introduction of the SARS-CoV-2 virus but demonstrates the value of stored antenatal serum samples as a resource for serosurveillance during future outbreaks.