cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Effects of the myotonic dystrophy mutation in muscle differentiation and apoptosis.
Creators: name: Storbeck, Christopher J.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Biology, Genetics.

description: Myotonic dystrophy (DM) is the most common inherited neuromuscular disorder of adult life. The genetic defect for DM was identified as an unstable CTG trinucleotide repeat found in the 3' untranslated region (UTR) of a serine threonine p&barbelow;rotein k&barbelow;inase, DMPK. Normal individuals possess 5--35 CTG repeats, typical adult DM patients have repeat sizes ranging from 80 to 1000 while cDM patients have from 1000 to several thousand CTG repeats. This discovery provided a molecular basis to account for large variability of penetrance and age of onset in DM. Work in our laboratory progressed from ascertaining mRNA levels in patient tissues to testing the hypothesis that overexpression of DMPK might cause features of DM. Transgenic mice expressed the human DMPK mRNA and protein in the appropriate tissues and had many features of DM including type I fibre atrophy, central nuclei and ringed fibres. Induction of expression resulted in about three fold higher levels of CTG 99 mRNA over CTG 11 mRNA at 48 hours post induction. Levels of cell death were assayed following induction and CTG 99 cell lines showed a marked level of cell death while CTG 11 cell lines did not. The presence of CTG repeats within mRNA therefore appears to be very problematic for the cell. Furthermore, we found that patient amniocytes and myoblasts are susceptible to staurosporine induced cell death. Taken together, this data suggests that myoblasts expressing the DMPK 3' UTR are prone to cell death in an expression level and repeat length dependent manner. In addition, patient cells were found to be susceptible in much the same way. These experiments also revealed that myogenin levels in vivo were reduced in transgenic embryos compared with wild type embryos suggesting that expression of the DMPK 3' UTR in vivo inhibits accumulation of myogenin and perhaps myogenesis. In adult mice there was consistent muscle atrophy in CTG 91 but not in CTG 11 mice despite much lower expression levels of the CTG 91 transgene. Together, these results indicate that expression of the DMPK 3' UTR by itself may inhibit myogenesis in vivo and contribute to pathological features of DM-like muscle atrophy. (Abstract shortened by UMI.)
Muddling through: the evolving relationship between sport, the Internet and broadband media
Creators: name: Hutchins, Brett
Publisher: name: Swinburne
Year: 2024

description: Sports content is central to the operation of national and global media markets, with infrastructure initiatives such as the National Broadband Network (NBN) set to have a major impact on how fans access and consume sport. Communications network speed, scale, functionality and accessibility are useful concepts with which to understand these changes and processes of media convergence. This article uses these concepts to guide analysis of the evolving relationship between sport, the Internet and broadband media. Two stories are presented, each supported by original evidence drawn from research interviews with media and sports industry professionals. The first examines sports audio content and changing norms of technology use and radio presentation. The second story concerns video content, industry codes of practice, and conflict between sports organisations and news outlets over the use of online footage and commercial practices in a fast-changing communications and media environment.
DWDM network protection/restoration with ring/cycle topologies.
Creators: name: Zhang, Hanxi.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Engineering, Electronics and Electrical.

description: In this thesis, we first discuss the differences between plain optical switches and wavelength routers, which are the building blocks for static WDM networks and wavelength routing networks respectively. We study the different features of these building blocks, and clarify the different meanings of 'ring/cycle topologies' in those two types of optical WDM networks. Then we propose a heuristic algorithm to find a set of link-covering rings to be used in WDM network protection/restoration. Our algorithm yields a scalable set of rings that covers most links in a sparse mesh network. To study whether it is beneficial to use P-cycles instead of pure rings in the WDM ring cover approach, we design a generic linear programming model for comparison purposes. By doing simulation studies with the model, we show that the method of P-cycle cover can only achieve very little performance improvement over pure ring cover. Thus from an engineering point of view, P-cycle cover is not practical. Finally we propose a distributed protocol to find rerouting paths by P-cycle decomposition, in wavelength routing networks. The restoration performance of the distributed protocol can be very close to the theoretical upper bound under our traffic distribution assumptions. That justifies P-cycle is a highly efficient topology for network protection/restoration.
Pressure drop in spouted beds.
Creators: name: Lama, R. F.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1957
Subjects: subject: Engineering, Chemical.

description: The present work contains the result of an investigation on pressure drop in sprouted beds. Six inch columns with a 0.5" air inlet orifice were used during the course of the investigation. The spouting medium was air. The gas flow rates vary from 84 to 1077 pounds per hour per square foot of column cross section. Particle diameters ranging from 0.079" to 0.25" were studied. Porosities of the packings vary from 0.358 to .0525. Correlations for the packed bed region and for the spouting point are presented. A six inch spouting unit consisting of four stages was also studied. Necessary gas flow rates to achieve spouting in each stage seems to indicate that the spouting bed technique can be improved by using several stages instead of one.
La rationalisation de la subjectivité moderne.
Creators: name: Harvey, Pascal.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Sociology, Theory and Methods.

description: Cette analyse propose d'envisager deux temps de l'organisation de la socialité à la lumière des enjeux qui entourent la subjectivité moderne. Il est avancé que la subjectivité moderne a parmi ses effets sociologiques importants l'individualisme. L'individualisme, alors qu'il recouvrait une dimension morale dans l'optique d'une conception supra-individuelle du Tout social au XVIIIe et XIXe siècles, ne s'inscrit plus, dans le monde contemporain, que dans les limites d'un lien social procédural et formel. Cette forme nouvelle du lien social, dont la domination technocratique de la société est partie prenante, s'inscrit dans les processus de rationalisation du monde moderne. Or, il est avancé que la subjectivité moderne prend part elle aussi à un processus de rationalisation. Aussi, en appréhendant l'organisation technocratique de la socialité contemporaine à partir du nouvel individualisme que la rationalisation de la subjectivité fait naître, il est possible de constater un changement des visées subjectives qui conduisent à des formes nouvelles d'autonomie.
Effekte umweltorientierter Verkehrskonzepte auf den kommunalen Haushalt
Creators: name: Sommer, Carsten
name: Leonhäuser, Daniel
name: Mucha, Elena
Publisher: name: My University
Year: 2016
Subjects: subject: Fahrradverkehr
subject: Fußgängerverkehr
subject: Kosteneffizienz
subject: Radverkehr
subject: Fußverkehr
subject: Maßnahmenwirkung
subject: Verkehr
subject: Transport

description: Vielerorts wurde erkannt, dass der Fuß- und Radverkehr nicht nur aus Aspekten des Umweltschutzes, sondern auch zur Attraktivitätssteigerung der Kommune, zur Steigerung der Lebensqualität und Gesundheitsförderung sowie zur Einsparung von Verkehrsflächen gefördert werden sollte. Entsprechende Konzepte sind wichtiger Bestandteil lokaler Verkehrsentwicklungspläne der Kommunen, dennoch stehen Kommunen aufgrund der meist knappen Haushaltskassen vor der Herausforderung, finanzielle Mittel in diesem Bereich möglichst effizient einzusetzen.Ziel dieser Forschungsarbeit war es, zu untersuchen, inwieweit Investitionen und Aufwendungen im Bereich des Fuß- und Radverkehrs für Kommunen effizient sind. Die kommunalen Ausgaben für den motorisierten Individualverkehr (MIV) und nicht-motorisierten Verkehr (NMV) wurden hierfür anhand von drei Beispielstädten – Bremen, Kassel und Kiel –gegenübergestellt. Weiterhin wurde die Wirksamkeit von Maßnahmen des nicht-motorisierten Verkehrs zur Förderung der Verkehrs- und Umweltentlastung ermittelt. Die Ergebnisse richten sich daher v. a. an Entscheidungsträger in den Kommunen, um den Fuß- und Radverkehr auch aus kosteneffizienten Gründen stärker zu fördern.
A multimedia database server for an integrated radiology information system.
Creators: name: Vital, Dominique.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Engineering, Electronics and Electrical.

description: The need for a computer-based information management system in a department of radiology is not new. For more than ten years now, it has been addressed by a variety of systems which all offer but partial solutions to the problem: Radiology Information System (RIS) for factual data, Picture Archiving and Communication System (PACS) for radiological images, voice-messaging system for verbal reports, etc. A multimedia information system is therefore required to integrate and expand the capabilities of each of these partial solutions. In this thesis, we investigate the information management aspects of such a multimedia information system. We characterize the radiological information, by identifying its components and their dynamic evolution. Based on this characterization, we apply concepts developed for the automated office environment to our system design: databases, ISO client-server architecture and ISO multimedia document architecture. As well, our system design includes the major achievements of PACS technology for radiological images storage and transfer. From all these, we elaborate a set of requirements for an information management system, and specify the functional architecture of a system which will meet these requirements. We also develop an appropriate data model for radiological information. Finally, we present a prototype implementing our system's specifications for textual and image data.
Language, identity and stress: A situated approach to acculturation.
Creators: name: Noels, Kimberly Ann.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Education, Bilingual and Multicultural.

description: Bilingualism is an important, if contentious, educational and socio-political issue, with implications for both society and individuals. This study considers several social psychological implications of developing second language (L2) competence by examining the links between ethnolinguistic identity, L2 self-confidence and efficiency, and psychological well-being. Participants included 368 Anglophone and 432 Francophone students attending a bilingual university. The results of confirmatory and exploratory fact or analyses showed that ethnic identity is multidimensional, and the number and types of factors depends upon the identity (L1-group vs. L2-group) and the language group (Anglophone vs. Francophone) considered. The extent of identification with each group differed according to the situation and the vitality of the group. In a similar manner, L2 self-confidence and L2-group contact varied as a function of group vitality, suggesting that contact and L2 competence mediate the link between vitality and identity. Indeed, correlational analyses confirmed the relations between contact, L2 self-confidence and identity in some situations. L2 self-confidence also mediated the connection between group contact, on the one hand, and proficiency and psychological well-being, on the other. These findings point to two major implications. First, future research should adopt a multidimensional, situational approach to the study of ethnic identity. Second, although developing L2 self-confidence may be associated with identity loss for some groups, it is also generally indicative of better mental health. Thus, whether bilingualism is an "additive" or a "subtractive" experience depends upon the outcome of interest.
The incidence of Guillain-Barre syndrome in Ontario and Quebec, 1983-1989, using hospital-service databases.
Creators: name: McLean, Mark Edward.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Health Sciences, Public Health.

description: Background. Guillain-Barre syndrome (GBS) is of public health interest in Canada, as well as the rest of North America, for two main reasons. It is occasionally a vaccine-associated adverse event and is also a differential diagnosis of poliomyelitis. Objectives. (1) To ascertain the incidence of GBS in the Canadian provinces of Ontario and Quebec for the years 1983-1989, inclusive. (2) To demonstrate the feasibility of measuring the incidence of GBS through internal record linkage of Canadian hospital-service data. Results. 1,302 and 1,031 records representing GBS incident admissions in Ontario and Quebec, respectively, were identified through the record-linkage procedure. The mean annual GBS incidence after age-and-sex-standardization to the 1986 Canadian census population was 2.02 per 100,000 person-years in Ontario and 2.30 in Quebec. The incidence was higher in older age-strata in both provinces (70-80 years), and was higher in males (M:F = 1.1). Reviews of charts of incident admissions of GBS cases reveal that 26.2%-32.6% of Ontario cases and 21.0%-24.0% of Quebec cases may be false positive diagnoses. No possible false negative cases were identified through chart review. Cross linkage of records belonging to the other province with records from the other dataset revealed 0.5% false negative misclassification of Ontario incident admissions and 1.8% for Quebec. Mortality figures obtained from CMDB were in both provinces less than those obtained in the hospital service data, indicating that it is unlikely a significant number of GBS cases die before reaching hospital. Conclusions. (1) It is possible to internally link records in the HMRI and Med-Echo databases into personal histories (cases) of a condition. (2) The high percentage of false positive misclassifications discovered on examination of incident admissions raises concern about the validity of HMRI and Med-Echo data for epidemiological purposes. (Abstract shortened by UMI.)
The new world of selling content - cricket as a case study
Creators: name: Beltrame, Stephanie
Publisher: name: Swinburne
Year: 2024

description: Cricket Australia has three main forms of cricket to manage - Test and first-class matches, Limited Overs cricket and Twenty20 cricket-and the sale of media rights is Cricket Australia's single biggest revenue stream. Traditionally the basic business model has been based on a mixed blessing of the sale of generally secure broadcast rights, which usually account for 60-70% of income, though this has largely been earned each year over only one Australian season: summer. However the world of sporting rights is rapidly changing and new considerations involve judgements about appropriate content platforms, payment options (such as free, pay, pay per view), transmission windows (live, delayed, highlights, ondemand/catch up, archive) and technology options (satellite, cable, IPTV, digital or analogue). Though major benefits continue for international cricket to remain with the mass coverage of free-to-air television, all sporting organisations face a highly complex decision making puzzle in the emerging world of diverse platform choice offering people so many different attractive products. The NBN is another wild card in the mix, which may eventually reshape how people access their chosen content on which platform, but which in the long run may possibly consolidate the number of devices people use in their media lives. Cricket Australia needs to ensure that it has a strong commercial overlay to create sustainable revenue and to protect its valuable assets, whilst ensuring that the best interests of the cricket fans remain at the heart of its decisions about content access, distribution and consumption in the future.
title: Alternative drugs go global
title: possible lead and/ or mercury intoxication from imported natural health products and a need for scientifically evaluated poisoning monitoring from environmental exposures
titleType: Subtitle
Creators: name: Budnik, Lygia Therese
name: Baur, Xaver
name: Harth, Volker
name: Hahn, Axel
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background With increases in globalization, cultural remedies from Chinese, Ayurvedic, Arab and other traditions have become more available to international consumers, offering unfamiliar “Natural Health Products” (NHP), used as alternative medicine or supplementary medicine. Contamination with toxic ingredients including lead, mercury, arsenic, and other toxic elements has been documented in several of these products from various parts of the globe, particularly from some parts of Asia and the Orient. Findings We have been following this development in the last 6 years and have analyzed n = 20 such products (60 analyses) from patients with intoxication symptoms in a pilot study, showing alarming high concentrations of mercury and/or lead (the first one in “therapeutic” doses). 82 % of the studied NHP contained lead concentrations above the EU limit for dietary supplements. 62 % of the samples exceeded the limit values for mercury. Elevated blood lead and mercury levels in patients along with clinical intoxication symptoms corroborate the causal assumption of intoxication (s). We present one detailed clinical case report of severe lead and mercury intoxications and give an overview about blood concentration related symptoms and signs of n = 41 case reports of mercury intoxications of the German monitoring BfR-DocCenter. Conclusions For NHP there is evidence on a distinct toxicological risk with alarming low awareness for a possible intoxication which prevents potentially life-saving diagnostic steps in affected cases. In many cases patients do not communicate the events to their physicians or the local health authority so that case reports (e.g. the BfR-DocCentre) are missing. Thus, there is an urgent need to raise awareness and to initiate more suitable monitory systems (e.g. National Monitoring of Poisonings) and control practice protecting the public.
MEK inhibitors enhance therapeutic response towards ATRA in NF1 associated malignant peripheral nerve sheath tumors (MPNST) in-vitro
Creators: name: Fischer-Huchzermeyer, Susan
name: Dombrowski, Anna
name: Wilke, Gordon
name: Stahn, Verena
name: Streubel, Anna
name: Mautner, Victor Felix
name: Harder, Anja
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten

description: Objective: Neurofibromatosis type 1 (NF1) is a hereditary tumor syndrome characterized by an increased risk of malignant peripheral nerve sheath tumors (MPNST). Chemotherapy of MPNST is still insufficient. In this study, we investigated whether human tumor Schwann cells derived from NF1 associated MPNST respond to all-trans retinoic acid (ATRA). We analyzed effects of ATRA and MEK inhibitor (MEKi) combination therapy. Methods: MPNST cell lines S462, T265, NSF1 were treated with ATRA and MEKi U0126 and PD0325901. We assessed cell viability, proliferation, migration, apoptosis and differentiation as well as mRNA expression of RAR and RXR subtypes and ATRA target genes such as CRABP2, CYP26A1, RARB and PDK1. We also analyzed CRABP2 methylation in cell lines and performed immunohistochemistry of human MPNST specimens. Results: ATRA therapy reduced viability and proliferation in S462 and T265 cells, accompanied by differentiation, apoptosis and reduced migration. NSF1 cells which lacked RXRG expression did not respond to ATRA. We furthermore demonstrated that ATRA signaling was functional for common targets, and that mRNA expression of CRABP2 and its targets was raised by ATRA therapy, whereas alternative pathways via FABP5 were not induced. Finally, combination of ATRA and MEKi demonstrated additively reduced viability of T265 and S462 cells. Conclusions: We observed therapeutic effects in two of three MPNST cell lines pronounced by combination therapy. These data point to a potentially successful treatment of MPNST by combined application of ATRA and MEK inhibitors such as U0126 or PD0325901.
Competitive fencers' affect: The intuitive-reflective appraisal model.
Creators: name: McPherson, Terry Lee.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Psychology, Cognitive.

description: The cognitive approach to the study of emotion is grounded in the belief that individuals are active agents and are able to exercise control over thought processes, motivation and behavior. Cognitions, causal thoughts in particular, play a central role in behavior and affect generation. Emotion depends upon how the individual cognitively appraises an event, not the event per se. Vallerand (1987) has proposed an intuitive-reflective appraisal model for self-related affects to examine the roles of intuitive (e.g. subjective performance assessment) and reflective (e.g. causal attributions) appraisals in the generation of self-related and general-type affects. The purpose of the present study was to test this model in a competitive fencing tournament and ascertain the relationships between three cognitive antecedents (intuitive appraisal, causal attributions, and intellectualization) and self-related and general-type affects. Results showed support for the main postulates of the model. Intuitive appraisal was found to have important and necessary effects on self-and general-type affects. This intuitive appraisal was shown to have more of an effect on affects than objective outcome (win/loss). Reflective appraisal processes, in the forms of causal attributions and task importance, were not necessary for affect generation, though task importance played a significant minimizing role in the experience of positive self- and general-type affects, particularly in the perceived failure condition. The results of the present study promote the use of sport specific models in the understanding of the relationship between athletes' cognitive antecedents and affect generation.
FROGBEAR Cluster 2.1 (2017) inscription location map
Creators: name: Rusk, Bruce, 1972-
name: Wang, Yue
name: Rols, Johan
Publisher: name: The University of British Columbia
Year: 2020

description: These maps show the locations of inscriptions recorded at six sites in the Jiyuan area: Jidu Temple; Fengxian Abbey; Yangtai Palace at Mount Wangwu; Ziwei Palace at Mount Wangwu; Tiantan Peak at Mount Wangwu; and Wangmu Cave at Mount Wangwu. The locations of inscriptions are keyed to number in the accompanying spreadsheet.
Selenium Status Is Positively Associated with Bone Mineral Density in Healthy Aging European Men
Creators: name: Beukhof, Carolien M.
name: Medici, Marco
name: Van Den Beld, Annewieke W.
name: Hollenbach, Birgit
name: Hoeg, Antonia
name: Visser, W. Edward
name: De Herder, Wouter W.
name: Visser, Theo J.
name: Schomburg, Lutz
name: Peeters, Robin P.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Objective It is still a matter of debate if subtle changes in selenium (Se) status affect thyroid function tests (TFTs) and bone mineral density (BMD). This is particularly relevant for the elderly, whose nutritional status is more vulnerable. Design and Methods We investigated Se status in a cohort of 387 healthy elderly men (median age 77 yrs; inter quartile range 75–80 yrs) in relation to TFTs and BMD. Se status was determined by measuring both plasma selenoprotein P (SePP) and Se. Results The overall Se status in our population was low normal with only 0.5% (2/387) of subjects meeting the criteria for Se deficiency. SePP and Se levels were not associated with thyroid stimulating hormone (TSH), free thyroxine (FT4), thyroxine (T4), triiodothyronine (T3) or reverse triiodothyronine (rT3) levels. The T3/T4 and T3/rT3 ratios, reflecting peripheral metabolism of thyroid hormone, were not associated with Se status either. SePP and Se were positively associated with total BMD and femoral trochanter BMD. Se, but not SePP, was positively associated with femoral neck and ward's BMD. Multivariate linear analyses showed that these associations remain statistically significant in a model including TSH, FT4, body mass index, physical performance score, age, smoking, diabetes mellitus and number of medication use. Conclusion Our study demonstrates that Se status, within the normal European marginally supplied range, is positively associated with BMD in healthy aging men, independent of thyroid function. Thyroid function tests appear unaffected by Se status in this population.
Uncoupling of EGFR–RAS signaling and nuclear localization of YBX1 in colorectal cancer
Creators: name: Roßner, F.
name: Gieseler, C.
name: Morkel, M.
name: Royer, H.-D.
name: Rivera, M.
name: Bläker, H.
name: Dietel, M.
name: Schäfer, R.
name: Sers, C.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: The transcription factor YBX1 can act as a mediator of signals transmitted via the EGFR–RAS–MAPK axis. YBX1 expression has been associated with tumor progression and prognosis in multiple types of cancer. Immunohistochemical studies have revealed dependency between YBX1 expression and individual EGFR family members. We analyzed YBX1 and EGFR family proteins in a colorectal cancer (CRC) cohort and provide functional analyses of YBX1 in the context of EGFR–RAS–MAPK signaling. Immunohistochemistry for YBX1 and EGFR family receptors with two antibodies for YBX1 and EGFR were performed and related to clinicopathological data. We employed Caco2 cells expressing an inducible KRASV12 gene to determine effects on localization and levels of YBX1. Mouse xenografts of Caco2-KRASV12 cells were used to determine YBX1 dynamics in a tissue context. The two different antibodies against YBX1 showed discordant immunohistochemical stainings in cell culture and clinical specimens. Expression of YBX1 and EGFR family members were not correlated in CRC. Analysis of Caco2 xenografts displayed again heterogeneity of YBX1 staining with both antibodies. Our results suggest that YBX1 is controlled via complex regulatory mechanisms involving tumor stroma interaction and signal transduction processes. Our study highlights that YBX1 antibodies have different specificities, advocating their use in a combined manner.
How do novice hapticians design? : [supplementary material]
Creators: name: Seifi, Hasti
name: Chun, Matthew
name: Gallacher, Colin
name: Schneider, Oliver
name: MacLean, Karon
Publisher: name: The University of British Columbia
Year: 2020

description: The supplementary materials include website screenshots of a call for participation in a Student Innovation Challenge, and 2 Student Innovation Challenge evaluation survey instruments associated with WHC '17.
title: Transformation of redox-sensitive to redox-stable iron-bound phosphorus in anoxic lake sediments under laboratory conditions
title: Transformation of redox-sensitive to redox-stable iron-bound phosphorus in anoxic lake sediments under laboratory conditions
titleType: AlternativeTitle
Creators: name: Heinrich, Lena
name: Rothe, Matthias
name: Braun, Burga
Publisher: name: My University
Year: 2021

description: Phosphorus (P) can be retained in mineral association with ferrous iron (Fe) as vivianite, Fe(II)3(PO4)2 . 8 H2O, in lake sediments. The mineral is formed and remains stable under anoxic non-sulphidogenic conditions and, therefore, acts as a long-term P sink. In laboratory experiments under anoxic conditions, we investigated whether P adsorbed to amorphous Fe(III)-hydroxide functioned as a precursor phase of vivianite when added to different sediments as a treatment. The untreated sediments served as controls and were naturally Fe-rich (559 (my)mol/g DW) and Fe-poor (219 (my)mol/g DW), respectively. The solid P binding forms analysed by sequential extraction and X-ray diffraction were related to coinciding pore water analyses and the bacterial community compositions of the sediments by bacterial 16S rRNA gene amplicon sequencing. In the treatments, within a period of 40 d, 70 % of the redox-sensitive Fe(III)-P was transformed into redox-stable P, which contained vivianite. The mineral was supersaturated in the pore water, but the presence of Fe(III)-P functioning as a precursor was sufficient for measurable vivianite formation. The composition of the microbial community did not differ significantly (PERMANOVA, p = 0.09) between treatment and control of the naturally Fe-rich sediment. In the naturally Fe-poor sediment, the microbial community changed significantly (PERMANOVA, p = 0.001) in response to the addition of Fe(III)-P to the sediment. The freshly formed redox-stable P was not retransferred to a redox-sensitive compound by aeration for 24 h until 90 % O2 saturation was reached in the sediment slurry. We conclude that 1) Fe(III)-hydroxide bound P, resulting from oxic conditions at the sediment-water interface, is immobilised during anoxic conditions and stable even after re-oxygenation; 2) the process is feasible within the time scales of anoxic lake stratification periods; and 3) in relatively Fe-poor lakes, Fe dosing can provide excess Fe to form the precursor. © 2020 Elsevier Ltd.
La privatisation des espaces publics en milieu urbain : le cas de Montréal.
Creators: name: Momer, Bernard P.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1991
Subjects: subject: Geography.

description: The public place has always provided a space where the social, commercial and political functions, generated by the sedentary way of life, were held. Although its functions have not greatly changed through time, the form of the public place has evolved to become an interior space. The fast growing development of the large cities in the last thirty years, has encouraged the construction of multipurpose complexes and shopping centres, which have taken over the role of the public place. This shift of the functions of the public place towards the interior is also a shift of the public space towards a privatized space, since most multipurpose complexes and shopping malls are privately owned. The study of this phenomenon, commonly known as the privatisation of public space, brings us to reflections on the freedom of the population and on the current and future planning of our cities.
Energy levels and properties of a semiconductor quantum well system: The influence of the surroundings and well parameters.
Creators: name: Fafard, Simon.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Physics, Condensed Matter.

description: The constituent layers of a semiconductor quantum well system were studied systematically and sequentially using various spectroscopic and optoelectronic techniques such as photoluminescence, photoreflectance, photovoltage, electroreflectance, or electroluminescence. Complete single quantum well samples with various well parameters were then studied with the appropriate technique. The purpose of the study was to find how the energy levels (the bound states as well as the continuum states) of the quantum well structure were influenced by the surroundings (such as the cap layer, the buffer or the substrate) and the well parameters. To that effect, the well width and the alloy composition (x) of an In$\sb{\rm x}$Ga$\sb{\rm 1-x}$As/GaAs single quantum well were varied, and the results obtained with samples having different cap thicknesses (the other parameters being kept the same) were compared. A theory predicting the influence on the energy levels of the cap layer thickness was developed, and experimental evidence was found in modulated reflectance measurements which showed spectral oscillations for energies above the barrier. The behavior is explained by deriving the wavefunction of the carriers with energies larger than the barrier (continuum states) taking into account the finite size of the cap layer. It was also found in the sequential study that in luminescence, depending on the excitation used, the substrate can contribute to the response obtained with the complete device. The influence of an external perturbation such as an electric field was also studied. Electroreflectance spectra showed that the bound states were Stark shifted, while the peaks of the cap-related oscillations of the continuum states were shifted linearly in energy with the electric field. Study of a multiple quantum well under the same conditions showed that the cap-related oscillations of the continuum states were strengthened by the presence of the additional wells. The theory also predicts that the first well(s), closer to the surface, will be more energy selective in capturing carriers in the continuum. This may result in different capture efficiencies for the various wells of a multiple quantum well structure.
title: Aquaporin-4 antibody testing
title: direct comparison of M1-AQP4-DNA-transfected cells with leaky scanning versus M23-AQP4-DNA-transfected cells as antigenic substrate
titleType: Subtitle
Creators: name: Jarius, Sven
name: Paul, Friedemann
name: Fechner, Kai
name: Ruprecht, Klemens
name: Kleiter, Ingo
name: Franciotta, Diego
name: Ringelstein, Marius
name: Pache, Florence
name: Aktas. Orhan
name: Wildemann, Brigitte
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background Neuromyelitis optica (NMO, Devic syndrome) is associated with antibodies to aquaporin-4 (NMO-IgG/AQP4-Ab) in the majority of cases. NMO- IgG/AQP4-Ab seropositivity in patients with NMO and its spectrum disorders has important differential diagnostic, prognostic and therapeutic implications. So-called cell-based assays (CBA) are thought to provide the best AQP4-Ab detection rates. Objective To compare directly the AQP4-IgG detection rates of the currently most widely used commercial CBA, which employs cells transfected with a full-length (M1)-human AQP4 DNA in a fashion that allows leaky scanning (LS) and thus expression of M23-AQP4 in addition to M1-AQP, to that of a newly developed CBA from the same manufacturer employing cells transfected with human M23-AQP4-DNA. Methods Results from 368 serum samples that had been referred for routine AQP4-IgG determination and had been tested in parallel in the two assays were compared. Results Seventy-seven out of 368 samples (20.9%) were positive for NMO-IgG/AQP4-Ab in at least one assay. Of these, 73 (94.8%) were positive in both assays. A single sample (1.3%) was exclusively positive in the novel assay; three samples (3.9%) were unequivocally positive only in the ‘classic’ assay due to high background intensity in the novel assay. Both median fluorescence intensity and background intensity were higher in the new assay. Conclusions This large study did not reveal significant differences in AQP4-IgG detection rates between the ‘classic’ CBA and a new M23-DNA-based CBA. Importantly, our results largely re-affirm the validity of previous studies that had used the ‘classic’ AQP4-CBA to establish NMO-IgG/AQP4-Ab seropositivity rates in NMO and in a variety of NMO spectrum disorders.
The ecology of alvar vegetation in Canada: Description, patterns, competition.
Creators: name: Belcher, Joyce W.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Biology, Ecology.

description: My research focused on (1) describing the vegetation of Canadian alvars, (2) examining ecological patterns in this system and (3) measuring the intensity of plant competition which occurs there. In chapter 1, ordination and classification techniques were used to describe alvar vegetation at two scales: local (within one alvar) and regional (among 4 alvar sites). At the local scale, changes in species composition corresponded to changes in soil depth and biomass. At the regional scale species composition was related primarily to geographic location--the southern site was distinct from the eastern and northern sites. Relationships between species distributions and soil depth and biomass could also be detected at this scale. In chapter 2, I examined the empirical relationships among important alvar state variables (soil depth, biomass and species richness) in order to test the predictions of the species richness model (forwarded by Grime and others) in a low biomass terrestrial system, and compare the pattern among 4 alvar sites. At all sites biomass was positively correlated with soil depth, suggesting that the soil depth gradient represents a gradient of increasing below-ground resources and decreasing above-ground resources. At each alvar, species richness varied curvilinearly with both biomass and soil depth; maximum species richness occurred at intermediate levels of these factors, as predicted by species richness models. However, the predicted decline in species richness at higher levels of biomass or soil depth was evident at only one site. In chapter 3, I present the results of a field experiment which measured the intensity of total, root and shoot competition along the gradient of soil depth at one alvar. Over all sites, the intensities of total and root competition were greater than zero; that of shoot competition was not. I suggest a model which relates the various effects of competition and of mutualism to the biomass range of interest. (Abstract shortened by UMI.)
Landnutzung und Klimaschutz
Creators: name: Köppen, Susanne
name: Heffe, Juliane
Publisher: name: Umweltbundesamt
Year: 2023
Subjects: Flächennutzung
Kohlenstoffmarkt

description: Zentrales Ziel dieses Leitfadens ist die Beschreibung der Rolle des Landnutzungsbereiches (LULUCF-Sektor) für den Klimaschutz sowie die Identifizierung von Anforderungen an eine Ausgestaltung und Nutzung von Marktansätzen zur Erreichung der Ziele des Übereinkommens von Paris. Der Leitfaden soll helfen, ein grundsätzliches Verständnis der Herausforderungen zu erhalten, die sich bei der Integration des LULUCF-Sektors in die internationale Klimapolitik stellen. Mit diesem Verständnis lassen sich Minderungspotenziale im Landnutzungsbereich und deren Hebung durch marktbezogene Anreize auf einer fundierten Basis entwickeln. Quelle: www.umweltbundesamt.de
Prospective Randomized Trial of Enoxaparin, Pentoxifylline and Ursodeoxycholic Acid for Prevention of Radiation-Induced Liver Toxicity
Creators: name: Seidensticker, Max
name: Seidensticker, Ricarda
name: Damm, Robert
name: Mohnike, Konrad
name: Pech, Maciej
name: Sangro, Bruno
name: Hass, Peter
name: Wust, Peter
name: Kropf, Siegfried
name: Gademann, Günther
name: Ricke, Jens
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik

description: Background/Aim Targeted radiotherapy of liver malignancies has found to be effective in selected patients. A key limiting factor of these therapies is the relatively low tolerance of the liver parenchyma to radiation. We sought to assess the preventive effects of a combined regimen of pentoxifylline (PTX), ursodeoxycholic acid (UDCA) and low-dose low molecular weight heparin (LMWH) on focal radiation-induced liver injury (fRILI). Methods and Materials Patients with liver metastases from colorectal carcinoma who were scheduled for local ablation by radiotherapy (image-guided high-dose-rate interstitial brachytherapy) were prospectively randomized to receive PTX, UDCA and LMWH for 8 weeks (treatment) or no medication (control). Focal RILI at follow-up was assessed using functional hepatobiliary magnetic resonance imaging (MRI). A minimal threshold dose, i.e. the dose to which the outer rim of the fRILI was formerly exposed to, was quantified by merging MRI and dosimetry data. Results Results from an intended interim-analysis made a premature termination necessary. Twenty-two patients were included in the per-protocol analysis. Minimal mean hepatic threshold dose 6 weeks after radiotherapy (primary endpoint) was significantly higher in the study treatment-group compared with the control (19.1 Gy versus 14.6 Gy, p = 0.011). Qualitative evidence of fRILI by MRI at 6 weeks was observed in 45.5% of patients in the treatment versus 90.9% of the control group. No significant differences between the groups were observed at the 12-week follow-up. Conclusions The post-therapeutic application of PTX, UDCA and low-dose LMWH significantly reduced the extent and incidence fRILI at 6 weeks after radiotherapy. The development of subsequent fRILI at 12 weeks (4 weeks after cessation of PTX, UDCA and LMWH during weeks 1–8) in the treatment group was comparable to the control group thus supporting the observation that the agents mitigated fRILI.
Networked urban screens and participatory public spaces
Creators: name: McQuire, Scott
Publisher: name: Swinburne
Year: 2024

description: Large video screens have become a distinctive aspect of contemporary cities. Despite their initial history as a medium predominantly used for advertising, recent developments suggest they can offer innovative tools for exploring new modes of social interaction and cultural exchange. This paper argues that large screens such as the one in Melbourne's Federation Square represent a new generation of screens, both in terms of spatial location and civic orientation. Drawing on fieldwork conducted in Australia, the Netherlands and the UK, a model is presented for three emerging 'alternative' uses of large screens. It is argued that, in the context of high-speed digital networks such as Australia's National Broadband Network, urban screens now have the potential to move beyond 'ambient television' to play a role in initiating new collective interactions in public space.
Body composition, metabolic profile and fitness in older versus younger type 2 diabetic participants to six months of aerobic exercise, resistance exercise or combined aerobic and resistance exercise.
Creators: name: Dittmann, Katherine R.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Health Sciences, Recreation.

description: In previous research, resistance exercise reduced HbA1c primarily in studies of older type 2 diabetic (T2DM) subjects (age>55), while aerobic exercise reduced HbA1c primarily in studies of relatively younger subjects. We compared changes in HbA1c, fitness and body composition in response to 6 months of exercise training in older (55-70 yrs: n= 53) vs. younger (40-54 yrs: n=44) T2DM participants in a randomized trial. Previously inactive T2DM subjects were randomized to aerobic exercise (A; progressing to 45min at 75% HR max, n=24), resistance exercise (R; 2-3 sets of 8-12 RM, n=23), combination aerobic and resistance training (AR; n=25) or a waiting control-list group (C; n=25). Each exercise group trained 3x/wk for 6 months. Strength testing was done using an 8 repetition maximum (RM) protocol for seated row, leg press and bench press. V02peak was assessed using graded treadmill protocols to volitional fatigue. A single cut CT scan was used to quantitate abdominal visceral and subcutaneous fat and mid-thigh muscle cross-section. All tests were performed at baseline and 6-months. The responses of older and younger subjects did not differ significantly on any measure. A1c decreased from 8.0% to 7.1% in younger A, and from 7.4% to 6.7% in older A. In AR decreases were similar: 7.9% to 6.8% in younger AR, 7.8% to 6.8% in older AR. A1c changed little in R: 7.8% to 7.7% in younger R, 7.7 to 7.3% in older R. No significant change in HbA1c occurred in either older or younger subjects in C. Mean increases in VO2peak for A were 6.9% in old and 7.4% in young and for AR were 7.6% in old and 4.9% in young. Strength increased in AR by 47.5%, 51.0% and 37.9% in young and 41.1%, 46.0% and 30.4% in young for bench press, leg press and seated row respectively. The R young group improved by 68.6%, 86.2% and 47.6% and the old by 44.3%, 72.3% and 31.9% for bench press, leg press and seated row respectively. The aerobic only group also improved in strength. Neither VO2peak nor strength changed significantly in C. Therefore, older (55-70 years old) and younger (40-54 year old) T2DM subjects responded similarly to aerobic, resistance or combined exercise in terms of glycemic control, strength, and aerobic fitness.
Replicating viral vector platform exploits alarmin signals for potent CD8+ T cell-mediated tumour immunotherapy
Creators: name: Kallert, Sandra M.
name: Darbre, Stephanie
name: Bonilla, Weldy V.
name: Kreutzfeldt, Mario
name: Page, Nicolas
name: Mueller, Philipp
name: Kreuzaler, Matthi
name: Loehning, Max
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Live attenuated vaccines
subject: Lymphocyte activation
subject: Tumour vaccines
subject: Viral vectors
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Viral infections lead to alarmin release and elicit potent cytotoxic effector T lymphocyte (CTLeff) responses. Conversely, the induction of protective tumour-specific CTLeff and their recruitment into the tumour remain challenging tasks. Here we show that lymphocytic choriomeningitis virus (LCMV) can be engineered to serve as a replication competent, stably-attenuated immunotherapy vector (artLCMV). artLCMV delivers tumour-associated antigens to dendritic cells for efficient CTL priming. Unlike replication-deficient vectors, artLCMV targets also lymphoid tissue stroma cells expressing the alarmin interleukin-33. By triggering interleukin-33 signals, artLCMV elicits CTLeff responses of higher magnitude and functionality than those induced by replication-deficient vectors. Superior anti-tumour efficacy of artLCMV immunotherapy depends on interleukin-33 signalling, and a massive CTLeff influx triggers an inflammatory conversion of the tumour microenvironment. Our observations suggest that replicating viral delivery systems can release alarmins for improved anti-tumour efficacy. These mechanistic insights may outweigh safety concerns around replicating viral vectors in cancer immunotherapy.
Preservare l'effimero: verso una proposta di archiviazione per il teatro e le arti dello spettacolo
Creators: name: Frattali, Arianna
name: Lepore, Ilaria
Publisher: name: Zenodo
Year: 2024

description: Intervento di disseminazione del progetto PNRR CHANGES 2024, “Preservare l’effimero: verso una proposta di archiviazione per il teatro e le arti dello spettaco-lo” al Convegno CUT (Consulta Universitaria Teatro) Nuovi crocevia per lo spettacolo. Linee di ricerca e giovani generazioni a confronto, Università degli Studi di Bologna