cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The economic burden of recurrence in elderly patients with completely resected, stage IIB/IIC or III melanoma: an analysis of the Surveillance, Epidemiology, and End Results-Medicare linked database
Creators: name: Jiang, Ruixuan
name: Wang, Travis
name: Liu, Yue
name: Kumar, Arun
name: Shen, Pangsibo
name: Fukunaga-Kalabis, Mizuho
name: Ayyagari, Rajeev
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Medicine
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Developmental Biology
Cancer
Science Policy

description: To compare healthcare resource utilization (HRU) and costs between patients with or without melanoma recurrence and between patients with distant or locoregional melanoma recurrence. Patients aged ≥65 years with completely resected, stage IIB/IIC or III melanoma were identified from Surveillance, Epidemiology, and End Results-Medicare data and stratified based on whether they experienced a recurrence, and whether it was distant or locoregional (separately for each stage). The index date was the date of recurrence (recurrence group) or a randomly assigned date (non-recurrence group). Patients in the recurrence and non-recurrence groups were propensity score-matched 1:1 based on patient characteristics; HRU and healthcare costs were compared between the 2 groups and between patients with distant or locoregional recurrence during the ≤24 months following index. After matching, 507 pairs of patients with recurrent or non-recurrent stage IIB/IIC melanoma (236 patients with distant recurrence, 271 with locoregional) and 141 pairs of patients with recurrent or non-recurrent stage III melanoma (50 patients with distant recurrence, 91 with locoregional) were included. During the first year following recurrence, unadjusted HRU was generally higher in patients with versus without recurrence and patients with distant versus locoregional recurrence among both stage IIB/IIC and III cohorts. Patients who experienced recurrence incurred $6,474 (stage IIB/IIC) or $6,112 (stage III) per patient per month (PPPM) more in unadjusted, all-cause, total healthcare costs than patients without recurrence (both p < 0.001). Patients with distant recurrence incurred $7,292 (stage IIB/IIC) or $5,436 (stage III) PPPM more in unadjusted, all-cause, total healthcare costs than patients with locoregional recurrence (both p < 0.05). Melanoma recurrence was identified using a claims-based algorithm. Economic burden is higher in patients with versus without melanoma recurrence and patients with distant versus locoregional recurrence. There is a high unmet need for adjuvant therapies that may help to prevent or delay recurrence.
Le projet Richelieu - Histoire du quartier
Creators: name: Kervegan, Paul
name: Duvette, Charlotte
Publisher: name: Zenodo
Year: 2024
Subjects: réutilisation
science ouverte
données de recherche
annotation
patrimoine

description: Cette présentation a été réalisée lors du webinaire du jeudi 28 mars 2024, organisé par le GTSO Données de Couperin. Lors de ce webinaire, Réutiliser des données, ils et elles l'ont fait ! Paroles de lauréats du prix Science Ouverte données de la recherche, 4 lauréats et lauréates du prix Science Ouverte des données de la recherche, mention « réutilisation de données » sont revenus sur leur projet et sur la manière dont la mise à disposition de jeux de données ouverts par d’autres ont permis de donner naissance à de nouveaux projets de recherche. https://gtsodataweb8.sciencesconf.org/

L’enregistrement est disponible ici : https://www.canal-u.tv/chaines/couperin/reutiliser-des-donnees-ils-et-elles-l-ont-fait-paroles-de-laureats-du-prix-science
Cost-effectiveness analysis of mosunetuzumab for treatment of relapsed or refractory follicular lymphoma after two or more lines of systemic therapy in the United States
Creators: name: Matasar, Matthew
name: Alvarez, Javier Sanchez
name: Parisé, Hélène
name: Zuk, Eric
name: Di Maio, Danilo
name: Shapouri, Sheila
name: Kim, Eunice
name: Lin, Shih-Wen
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Medicine
Pharmacology
Science Policy

description: Mosunetuzumab has received accelerated approval by the US Food and Drug Administration for adult patients with relapsed or refractory (R/R) follicular lymphoma (FL) after two or more lines of systemic therapy. We evaluated the cost-effectiveness of mosunetuzumab for the treatment of R/R FL from a US private payer perspective. A partitioned survival model simulated lifetime costs and outcomes of mosunetuzumab against seven comparators: axicabtagene ciloleucel (axi-cel), tisagenlecleucel (tisa-cel), tazemetostat (taz, EZH2 wild-type only), rituximab plus lenalidomide (R-Len) or bendamustine (R-Benda), obinutuzumab plus bendamustine (O-Benda), and a retrospective real-world cohort (RW) based on current patterns of care derived from US electronic health records (Flatiron Health). Efficacy data for mosunetuzumab were from the pivotal Phase II GO29781 trial (NCT02500407). Relative treatment efficacy was estimated from indirect treatment comparisons (ITCs). Costs included were related to treatment, adverse events, routine care, and terminal care. Except for drug costs (March 2023), all costs were inflated to 2022 US dollars. Costs and quality-adjusted life-years (QALYs) were used to calculate incremental cost-effectiveness ratios (ICERs). Net monetary benefit (NMB) was calculated using a willingness-to-pay (WTP) threshold of $150,000/QALY. Mosunetuzumab dominated taz, tisa-cel, and axi-cel with greater QALYs and lower costs. Mosunetuzumab was projected to be cost-effective against R-Benda, O-Benda, and RW with ICERs of $78,607, $42,731, and $21,434, respectively. Mosunetuzumab incurred lower costs but lower QALYs vs. R-Len. NMBs showed that mosunetuzumab was cost-effective against comparators except R-Len. Without head-to-head comparative data, the model had to rely on ITCs, some of which were affected by residual bias. Model inputs were obtained from multiple sources. Extensive sensitivity analyses assessed the importance of these uncertainties. Mosunetuzumab is estimated to be cost-effective compared with approved regimens except R-Len for the treatment of adults with R/R FL.
Cephalanthera rubra Rich.
Creators: name: Konrad Lauber
name: Gerhart Wagner
name: Andreas Gygax
Publisher: name: Haupt Verlag
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Cephalanthera
Cephalanthera rubra

description: Cephalanthera rubra (L.) Rich.
Artbeschreibung: 20-50 cm hoch, mit lanzettlichen, stängelumfassenden Blättern. Stängel oben fein drüsig, mit 4-12 Blüten in den Winkeln von Tragblättern. Perigonblätter dunkelrosa, spitz, alle zusammenneigend und die Lippe meist verdeckend (nur bei Cephalanthera). Das vordere Glied der Lippe fein zugespitzt. Kein Sporn. Fruchtknoten fein behaart.
Blütezeit: 6-7
Standort und Verbreitung in der Schweiz: Lichte Wälder in sonniger Lage / kollin-montan / CH
Verbreitung global: Europäisch-westasiatisch
Ökologische Zeigerwerte nach Landolt & al. (2010)
BodenfaktorenKlimafaktorenSalztoleranzFeuchtezahl FfrischLichtzahl LhalbschattigSalzzeichen--Reaktionszahl Rneutral bis basisch (pH 5.5-8.5)Temperaturzahl Tkollin (Laubmischwälder mit Eichen)Nährstoffzahl NnährstoffarmKontinentalitätszahl Ksubkontinental (niedrige relative Luftfeuchtigkeit, grosse Temperaturschwankungen, eher kalte Winter)
Volksname Deutscher Name: Rotes Waldvögelein, Rote Kopforche Nom français: Céphalanthère rouge Nome italiano: Cefalantera rossa
description: Published as part of Konrad Lauber, Gerhart Wagner & Andreas Gygax, 2018, Flora Helvetica - Orchidaceae, pp. 1324-1362 in Flora Helvetica, Bern :Haupt Verlag on page 1342
Schizopyga frigida Cresson 1870
Creators: name: Varga, Oleksandr
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Ichneumonidae
Schizopyga
Schizopyga frigida

description: Schizopyga frigida Cresson, 1870
Records. Ivano-Frankivsk and Transcarpathian Regions (Varga, 2018b).
Material examined. Khmelnytskyi Reg.: 1 ♀, Shydlivtsi, SN, 28.vii.1988, leg. V. Tolkanitz.
Distribution. Holarctic; Ukraine: Ivano-Frankivsk, Khmelnytskyi and Transcarpathian Regs.
Biology. CMF, CEMF. May–October.
description: Published as part of Varga, Oleksandr, 2019, Taxonomy and distribution of pimpline parasitoids (Hymenoptera, Ichneumonidae, Pimplinae) in Ukraine, pp. 1-65 in Zootaxa 4693 (1) on page 41, DOI: 10.11646/zootaxa.4693.1.1, http://zenodo.org/record/3529018
Additional file 4 of Eigen-Epistasis for detecting gene-gene interactions
Creators: name: Stanislas, Virginie
name: Dalmasso, Cyril
name: Ambroise, Christophe
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology

description: Figure S4. Comparison of execution time required to model interaction and to fit Group Lasso for the five first settings of the realistic simulation study. Execution time. Median of the execution time to model interaction and to fit Group Lasso for the five first settings of the realistic simulation study. (PDF 8 kb)
FETAL PITUITARY DYSFUNCTION AND PROLONGED GESTATION: A CASE STUDY OF A JERSEY CROSSBRED COW
Creators: name: Kendrick, R
name: Jackson, A
Publisher: name: Continental Journal
Year: 2024
Subjects: Prolonged gestation, pituitary hypoplasia, Jersey crossbred cow, parturition, dexamethasone, cloprostenol sodium, fetal pituitary gland, oxytocin, rectal examination, ultrasonography

description: Prolonged gestation in cattle can have various causes, including pituitary abnormality which can disrupt the physiological mechanism of parturition. In this case study, a 3-year-old Jersey crossbred cow with suspected pituitary hypoplasia was treated with dexamethasone and cloprostenol sodium to terminate her pregnancy after 15 months. A dead male calf was vaginally delivered within 48 hours, and histopathological analysis revealed an underdeveloped pituitary. The cow was then treated with oxytocin and successfully inseminated twice after showing estrus signs. The role of the fetal pituitary gland in parturition and the difficulty in reversing this process once it has started are also discussed. Diagnosis of prolonged gestation may involve rectal examination, ultrasonographic scans, and fetal fluid analysis. Treatment for inducing parturition in cows typically involves administering cloprostenol and dexamethasone. This case highlights the importance of considering pituitary abnormality as a possible cause of prolonged gestation in cattle and the need to manage such cases with minimal harm to the cow
Chamorchis alpina Rich.
Creators: name: Konrad Lauber
name: Gerhart Wagner
name: Andreas Gygax
Publisher: name: Haupt Verlag
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Chamorchis
Chamorchis alpina

description: Chamorchis alpina (L.) Rich.
Artbeschreibung: Stängel 5-15 cm hoch, nur am Grund beblättert. Blätter lineal, rinnig gefaltet, fleischig, oft so hoch wie der Blütenstand, dieser bis 4 cm lang, 5-10 blütig. Blüten gelbgrün bis rotbraun. Perigonblätter helmförmig zusammenneigend, die äusseren höchstens 4 mm lang. Lippe meist gelb, 3-4 mm lang, Ränder nach rückwärts gebogen. Kein Sporn.
Blütezeit: 7-8
Standort und Verbreitung in der Schweiz: Rasen, meist auf Kalk / subalpin-alpin / A
Verbreitung global: Eurarktisch-alpin
Ökologische Zeigerwerte nach Landolt & al. (2010)
BodenfaktorenKlimafaktorenSalztoleranzFeuchtezahl Fmässig trockenLichtzahl Lsehr hellSalzzeichen--Reaktionszahl Rbasisch (pH 6.5->8.5)Temperaturzahl Tunter-alpin, supra-subalpin und ober-subalpin (Arven-Lärchenwälder)Nährstoffzahl Nsehr nährstoffarmKontinentalitätszahl Ksubkontinental (niedrige relative Luftfeuchtigkeit, grosse Temperaturschwankungen, eher kalte Winter)
Volksname Deutscher Name: Zwergorchis, Zwergknabenkraut Nom français: Chamorchis des Alpes Nome italiano: Gramignola alpina
description: Published as part of Konrad Lauber, Gerhart Wagner & Andreas Gygax, 2018, Flora Helvetica - Orchidaceae, pp. 1324-1362 in Flora Helvetica, Bern :Haupt Verlag on page 1342
Additional file 3: of Respondentsâ   report of a clinician-diagnosed depression in health surveys: comparison with DSM-IV mental disorders in the general adult population in Germany
Creators: name: Maske, Ulrike
name: Hapke, Ulfert
name: Riedel-Heller, Steffi
name: Busch, Markus
name: Kessler, Ronald
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Mental Health

description: Mental health characteristics of participants who report a 12-month clinician-diagnosed depression who did or did not meet the criteria for 12-month major depressive disorder (MDD). (DOCX 22Â kb)
Coeloglossum viride Hartm.
Creators: name: Konrad Lauber
name: Gerhart Wagner
name: Andreas Gygax
Publisher: name: Haupt Verlag
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Coeloglossum
Coeloglossum viride

description: Coeloglossum viride (L.) Hartm.
Artbeschreibung: Stängel 5-20 cm hoch, kantig. Untere Blätter eiförmig, obere lanzettlich. Blütenstand zylindrisch, 5-25 blütig. Perigonblätter grün, oft rot überlaufen, zu einem Helm mit ca. 5 mm Durchmesser zusammenneigend. Lippe 5-10 mm lang, gelbgrün bis rotbraun, abwärts gerichtet, flach, vorn 3teilig, mit kurzem Mittelabschnitt. Sporn sackförmig, höchstens 1/4 so lang wie der Fruchtknoten.
Blütezeit: 5-7
Standort und Verbreitung in der Schweiz: Borstgraswiesen, Zwergstrauchheiden / (kollin-)montan-alpin / A, M in Alpennähe, J (fehlt SH)
Verbreitung global: Eurosibirisch-nordamerikanisch
Ökologische Zeigerwerte nach Landolt & al. (2010)
BodenfaktorenKlimafaktorenSalztoleranzFeuchtezahl Fmässig feucht; Feuchtigkeit stark wechselnd (mehr als ± 2 Stufen)Lichtzahl LhellSalzzeichen--Reaktionszahl Rschwach sauer bis neutral (pH 4.5-7.5)Temperaturzahl Tsubalpin (Fichtenwälder ohne Buchen bis zur Obergrenze der Fichte)Nährstoffzahl NnährstoffarmKontinentalitätszahl Ksubozeanisch bis subkontinental (mittlere Luftfeuchtigkeit, mässige Temperaturschwankungen und mässig tiefe Wintertemperaturen)
Volksname Deutscher Name: Grüne Hohlzunge Nom français: Orchis grenouille, Orchis vert Nome italiano: Celoglosso
description: Published as part of Konrad Lauber, Gerhart Wagner & Andreas Gygax, 2018, Flora Helvetica - Orchidaceae, pp. 1324-1362 in Flora Helvetica, Bern :Haupt Verlag on page 1342
Additional file 3: of Human resources for health (and rehabilitation): Six Rehab-Workforce Challenges for the century
Creators: name: Jesus, Tiago
name: Landry, Michel
name: Dussault, Gilles
name: InĂŞs Fronteira
Publisher: name: Figshare
Year: 2017
Subjects: subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology

description: Data extraction table. (DOCX 111 kb)
Evaluating the cost utility of estradiol plus dydrogesterone for the treatment of menopausal women in China
Creators: name: Anne, Rautenberg Tamlyn
name: Downes, Martin
name: Simoncini, Tommaso
name: Yu, Qi
name: Ren, Mulan
name: Wang, Yaping
name: Graziano, Custodio Marcelo
name: Kim, Kyoo
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy

description: Evaluate the cost utility of menopausal hormone therapy for women in China. A bespoke Markov cost utility model was developed to evaluate a cohort of symptomatic perimenopausal women (>45 years) with intact uterus in China in accordance with China’s Pharmacoeconomic guideline. Short (5-year) and long (10-year) treatment durations were evaluated over a lifetime model time horizon with 12-month cycle duration. Societal and healthcare payer perspectives were evaluated in the context of a primary care provider/prescriber, outpatient setting with inpatient care for patients with chronic conditions. Disease risk and mortality parameters were derived from focused literature searches, and China Diagnosis-related Group cost data was included. Comprehensive scenario, univariate and probabilistic sensitivity analysis were undertaken along with independent validation. This is the first model to include MHT-related disease risks. According to base case results, the total cost for MHT was 22,516$ (150,106¥) and total quality adjusted life years 12.32 versus total cost of no MHT 30,824$ (205,495¥) and total quality adjusted life years 11.16 resulting in a dominant incremental cost effectiveness ratio of −7,184$ (−47,898¥) per QALY. Results hold true over a range of univariate deterministic sensitivity and scenario analyses. Probabilistic analysis showed a 91% probability of being cost effective at a willingness to pay threshold of three times Gross Domestic Product per capita in China. Contingent on the structure and assumptions of the model, combination of estradiol plus dydrogesterone MHT is potentially cost saving in symptomatic women over the age of 45 years in China. Menopausal hormone therapy is publicly funded in many countries to alleviate symptoms of menopause; however, uptake has been comparatively slow in China. This has implications for the estimated 168 million menopausal-aged women. This analysis is the first to evaluate the cost effectiveness of menopausal hormone therapy in China using best practice principles and incorporating longer term disease risks. Menopausal hormone therapy is potentially cost saving in the context of China.
Corallorhiza trifida Chatel.
Creators: name: Konrad Lauber
name: Gerhart Wagner
name: Andreas Gygax
Publisher: name: Haupt Verlag
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Corallorhiza
Corallorhiza trifida

description: Corallorhiza trifida Châtel.
Artbeschreibung: Grünlich-gelber bis brauner Saprophyt mit wenig Chlorophyll. Stängel 10-25 cm hoch, mit wenigen Blattschuppen. Blütenstand 4-10 blütig. Perigonblätter schmal-lanzettlich, 4-5 mm lang, innerer wenig kürzer als äussere, die beiden seitlichen abstehend. Lippe oval, kürzer als die äusseren Perigonblätter, meist ganzrandig, weiss, mit erhabenen roten Punkten und Strichen. Sporn nur ca. 1/4 so lang wie der Fruchtknoten und diesem anliegend.
Blütezeit: 5-7
Standort und Verbreitung in der Schweiz: Schattige, moosige Fichten- und Föhrenwälder / montan-subalpin / A, M am Alpenrand, J
Verbreitung global: Eurosibirisch-nordamerikanisch
Ökologische Zeigerwerte nach Landolt & al. (2010)
BodenfaktorenKlimafaktorenSalztoleranzFeuchtezahl Ffeucht; Feuchtigkeit mässig wechselnd (± 1-2 Stufen)Lichtzahl Lsehr schattigSalzzeichen--Reaktionszahl Rschwach sauer bis neutral (pH 4.5-7.5)Temperaturzahl Tunter-subalpin und ober-montanNährstoffzahl NnährstoffarmKontinentalitätszahl Ksubozeanisch bis subkontinental (mittlere Luftfeuchtigkeit, mässige Temperaturschwankungen und mässig tiefe Wintertemperaturen)
Volksname Deutscher Name: Korallenwurz Nom français: Racine de corail Nome italiano: Coralloriza
description: Published as part of Konrad Lauber, Gerhart Wagner & Andreas Gygax, 2018, Flora Helvetica - Orchidaceae, pp. 1324-1362 in Flora Helvetica, Bern :Haupt Verlag on page 1342
Additional file 2: of Human resources for health (and rehabilitation): Six Rehab-Workforce Challenges for the century
Creators: name: Jesus, Tiago
name: Landry, Michel
name: Dussault, Gilles
name: InĂŞs Fronteira
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Marine Biology

description: Papers excluded within the synthesis stage, and the reasons to do so. (DOCX 20 kb)
Cost-effectiveness of axicabtagene ciloleucel versus tisagenlecleucel for the treatment of 3L + relapsed/refractory large B-cell lymphoma in the United States: incorporating longer survival results
Creators: name: Oluwole, Olalekan O.
name: Ray, Markqayne D.
name: Davies, Neil
name: Bradford, Rory
name: Jones, Calum
name: Patel, Anik R.
name: Locke, Frederick L.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: To provide an update on the cost-effectiveness of the chimeric antigen receptor (CAR) T-cell therapies axicabtagene ciloleucel (axi-cel) and tisagenlecleucel (tisa-cel) for the treatment of relapsed/refractory (r/r) large B-cell lymphoma (LBCL) among patients who have previously received ≥2 lines of systemic therapy using more mature clinical trial data cuts (60 months for axi-cel overall survival [OS] and 45 months for tisa-cel OS and progression-free survival [PFS]). A partitioned survival model consisting of three health states (pre-progression, post-progression and death) was used to estimate quality-adjusted life years (QALYs) and costs associated with axi-cel and tisa-cel over a lifetime horizon. PFS and OS inputs for axi-cel and tisa-cel were based on a previously published matching-adjusted indirect treatment comparison (MAIC). Long-term OS and PFS were extrapolated using parametric survival mixture cure models (PS-MCMs). Costs of CAR-T cell therapy drug acquisition and administration, conditioning chemotherapy, apheresis, CAR T-specific monitoring, stem cell transplant, hospitalization, adverse events, routine care, and terminal care were sourced from US cost databases. Health state utilities were derived from previous publications. Model inputs were varied using a range of sensitivity and scenario analyses. Compared with tisa-cel, axi-cel resulted in 2.51 additional QALYs and $50,185 additional costs (an incremental cost-effectiveness ratio [ICER] of $19,994 per QALY gained). In probabilistic sensitivity analysis (PSA), the ICER for axi-cel versus tisa-cel was ≤$50,000/QALY in 99.4% of simulations and ≤$33,500 in 99% of simulations. Axi-cel remained cost-effective versus tisa-cel (assuming a willingness-to-pay threshold of $150,000 per QALY) across a range of scenarios. With longer-term survival data, axi-cel continues to represent a cost-effective option versus tisa-cel for treatment of r/r LBCL among patients who have previously received ≥2 lines of systemic therapy, from a US payer perspective.
Evaluating the cost utility of estradiol plus dydrogesterone for the treatment of menopausal women in China
Creators: name: Rautenberg, Tamlyn Anne
name: Downes, Martin
name: Simoncini, Tommaso
name: Qi, Yu
name: Ren, Mulan
name: Wang, Yaping
name: Graziano, Custodio Marcelo
name: Kim, Kyoo
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Science Policy

description: Aim: Evaluate the cost utility of menopausal hormone therapy for women in China. Materials and Methods: A bespoke Markov cost utility model was developed to evaluate a cohort of symptomatic perimenopausal women (>45 years) with intact uterus in China in accordance with China’s Pharmacoeconomic guideline. Short (5-year) and long (10-year) treatment durations were evaluated over a lifetime model time horizon with 12-month cycle duration. Societal and healthcare payer perspectives were evaluated in the context of a primary care provider/prescriber, outpatient setting with inpatient care for patients with chronic conditions. Disease risk and mortality parameters were derived from focused literature searches, and China Diagnosis-related Group cost data was included. Comprehensive scenario, univariate and probabilistic sensitivity analysis were undertaken along with independent validation. This is the first model to include MHT-related disease risks. Results: According to base case results, the total cost for MHT was 22,516$ (150,106¥) and total quality adjusted life years 12.32 versus total cost of no MHT 30,824$ (205,495¥) and total quality adjusted life years 11.16 resulting in a dominant incremental cost effectiveness ratio of -7,184$ (-47,898¥) per QALY. Results hold true over a range of univariate deterministic sensitivity and scenario analyses. Probabilistic analysis showed a 91% probability of being cost effective at a willingness to pay threshold of three times Gross Domestic Product per capita in China. Conclusion: Contingent on the structure and assumptions of the model, combination of estradiol plus dydrogesterone MHT is potentially cost saving in symptomatic women over the age of 45 years in China. Menopausal hormone therapy is publicly funded in many countries to alleviate symptoms of menopause; however, uptake has been comparatively slow in China. This has implications for the estimated 168 million menopausal-aged women. This analysis is the first to evaluate the cost effectiveness of menopausal hormone therapy in China using best practice principles and incorporating longer term disease risks. Menopausal hormone therapy is potentially cost saving in the context of China.
Schizopyga podagrica Gravenhorst 1829
Creators: name: Varga, Oleksandr
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Ichneumonidae
Schizopyga
Schizopyga podagrica

description: Schizopyga podagrica Gravenhorst, 1829
Records. Ukraine (Kasparyan, 1981), Ivano-Frankivsk and Transcarpathian Regions (Varga, 2018b).
Material examined. Crimea: 1 ♂, Alushta, SN, 12.vii.1979, leg. A. Lelei; Donetsk Reg.: 1 ♀, Khomutovskyi Steppe Reserve, SN, 24.vi.1979, leg. A. Kotenko; 1 ♀, idem, SN, 31.v.1983, leg. V. Tolkanitz; 1 ♂, idem, SN, 16.vi.1983, leg. A. Kotenko; 1 ♀, Kamyani Mohyly Reserve, SN, 15.vi.1975, leg. V. Tolkanitz; 1 ♂, idem, SN, 5.vi.1978, leg. V. Odnosum; 1 ♀, idem, SN, 24.vi.1979, leg. V. Tolkanitz; 1 ♀, Bogorodychne, SN, 20.vi.1983, leg. I. Plyushch; 1 ♂, idem, SN, 22.vi.1983; 1 ♂, Klishchiivka, SN, 17.v.1998, leg. A. Kotenko; Kharkiv Reg.: 1 ♀, SN, 15.vii.1975, leg. M. Narolsky; 1 ♂, Vovchansk Distr., Yefremivka, SN, 27.vii.1984; 1 ♀, Krasnokutsk, SN, 15.vi.1992; 1 ♀, idem, SN, 9.vii.1992, leg. A. Kotenko; Kropyvnytskyi Reg.: 1 ♂, Bogdanove, SN, 14.vi.1983; Kyiv Reg.: 1 ♂, Kyiv, Kruglyk, SN, 31.vii.1980, leg. V. Ermolenko; 1 ♀, 1 ♂, idem, SN, 4.ix.1980, leg. A. Kotenko; 1 ♀, Kyiv, Khodosivka, SN, 16.viii.2005, leg. M. Nesterov; Lugansk Reg.: 1 ♂, Luganks NR, Striltsivskyi Steppe, SN, 27.vi.1983; 1 ♂, Provallya, SN, 1.viii.1983, leg. A. Kotenko; Zaporizhzhya Reg.: 1 ♀, 2–3 km S of Vasylivka, SN, 9.vii.1980, leg. V. Tolkanitz.
Distribution. Palaearctic; Ukraine: Crimea, Donetsk, Ivano-Frankivsk, Kharkiv, Kropyvnytskyi, Kyiv, Lugansk, Transcarpathian, and Zaporizhzhya Regs.
Biology. CMF, CEMF, CSF, EEFS, PS. May–September.
description: Published as part of Varga, Oleksandr, 2019, Taxonomy and distribution of pimpline parasitoids (Hymenoptera, Ichneumonidae, Pimplinae) in Ukraine, pp. 1-65 in Zootaxa 4693 (1) on pages 41-42, DOI: 10.11646/zootaxa.4693.1.1, http://zenodo.org/record/3529018
Cypripedium calceolus L.
Creators: name: Konrad Lauber
name: Gerhart Wagner
name: Andreas Gygax
Publisher: name: Haupt Verlag
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Cypripedium
Cypripedium calceolus

description: Cypripedium calceolus L.
Artbeschreibung: 15-50 cm hoch, mit 2-4 breit-elliptischen, spitzen, stängelumfassenden, fein behaarten Blättern und 1-2, selten 3 Blüten. Die 3 äusseren Perigonblätter bis 5 cm lang, breit-lanzettlich, abstehend, die beiden inneren auf ca. 4/5 der Länge verwachsen und abwärts gerichtet, alle purpurbraun. Lippe sehr gross, bauchig aufgeblasen, gelb, 3-4 cm lang. Kein Sporn.
Blütezeit: 5-6(-7)
Standort und Verbreitung in der Schweiz: Wälder, Gebüsche / kollin-subalpin / CH
Verbreitung global: Eurasiatisch
Ökologische Zeigerwerte nach Landolt & al. (2010)
BodenfaktorenKlimafaktorenSalztoleranzFeuchtezahl Fmässig feucht; Feuchtigkeit mässig wechselnd (± 1-2 Stufen)Lichtzahl LhalbschattigSalzzeichen--Reaktionszahl Rneutral bis basisch (pH 5.5-8.5)Temperaturzahl Tunter-montan und ober-kollinNährstoffzahl NnährstoffarmKontinentalitätszahl Ksubozeanisch bis subkontinental (mittlere Luftfeuchtigkeit, mässige Temperaturschwankungen und mässig tiefe Wintertemperaturen)
Volksname Deutscher Name: Frauenschuh Nom français: Sabot de Vénus Nome italiano: Pianelle della Madonna
description: Published as part of Konrad Lauber, Gerhart Wagner & Andreas Gygax, 2018, Flora Helvetica - Orchidaceae, pp. 1324-1362 in Flora Helvetica, Bern :Haupt Verlag on page 1342
The potential clinical impact and cost-effectiveness of the updated COVID-19 mRNA Autumn 2024 vaccines in the United Kingdom
Creators: name: Kohli, Michele
name: Maschio, Michael
name: Lee, Amy
name: Joshi, Keya
name: Carroll, Stuart
name: Balogh, Orsolya
name: Van de Velde, Nicolas
name: Beck, Ekkehard
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: To estimate the potential clinical impact and cost-effectiveness of a United Kingdom (UK) Autumn 2024 vaccination campaign with an updated Moderna COVID-19 vaccine in adults ≥65 years and eligible persons 6 months to 64 years of age over a 1-year time horizon (September 2024–August 2025). A compartmental Susceptible-Exposed-Infected-Recovered model was adapted to reflect COVID-19 cases in the UK. Numbers of symptomatic infections, COVID-19–related hospitalizations and deaths, costs, and quality-adjusted life-years (QALYs) were predicted using a decision tree. The incremental cost-effectiveness ratio (ICER) of an updated Moderna mRNA vaccine (Moderna Autumn 2024 Campaign) was compared to No Autumn 2024 vaccine and to an updated Pfizer-BioNTech mRNA Autumn 2024 vaccine, from a healthcare perspective. The Moderna Autumn 2024 Vaccination Campaign is predicted to decrease the expected 8.3 million symptomatic infections with no vaccination by 19% to 6.7 million. Hospitalizations, long COVID cases, and deaths are expected to decline by 27,000 (−38%), 59,000 (−19%), and 6,000 (−43%), respectively. The Moderna Autumn 2024 Campaign will increase QALYs by 78,000 and costs by £665 million, yielding an ICER of £8,500/QALY gained. Sensitivity analyses suggest that vaccine effectiveness (VE) and waning, symptomatic infection incidence, hospitalization rates, and mortality rates drive cost-effectiveness. Vaccination remains cost-effective when lowering the target population to ≥50 years. Use of the Moderna vaccine is expected to prevent 8,000 more hospitalizations and 1,700 more deaths than the updated Pfizer-BioNTech vaccine. Vaccination of the eligible population would contribute to significant reductions in hospitalizations, deaths, and long COVID in the UK in the 2024–2025 season. Expanding the target population continues to be cost-effective. Use of the Moderna Autumn 2024 Campaign is predicted to reduce SARS-CoV-2 infections and associated outcomes in a cost-effective manner and will contribute to a more resilient healthcare system in the UK.
Dactylorhiza cruenta Soo
Creators: name: Konrad Lauber
name: Gerhart Wagner
name: Andreas Gygax
Publisher: name: Haupt Verlag
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Dactylorhiza
Dactylorhiza cruenta

description: Dactylorhiza cruenta (O. F. Müll.) Soó
Artbeschreibung: Stängel 10-30 cm hoch, hohl, mit nur 3-4 nicht tragblattartigen Stängelblättern. Diese lanzettlich, vom Grund an verschmälert, auf Ober- und Unterseite unregelmässig dunkel gefleckt (nur bei dieser Art!). Tragblätter purpurn. Blüten leuchtend purpurn. Sonst wie D. incarnata.
Blütezeit: 6-7
Standort und Verbreitung in der Schweiz: Flachmoore / subalpin / GR, vereinzelt VS und BO
Verbreitung global: Eurosibirisch
Ökologische Zeigerwerte nach Landolt & al. (2010)
BodenfaktorenKlimafaktorenSalztoleranzFeuchtezahl Fnass; Feuchtigkeit mässig wechselnd (± 1-2 Stufen)Lichtzahl LhellSalzzeichen--Reaktionszahl Rbasisch (pH 6.5->8.5)Temperaturzahl Tsubalpin (Fichtenwälder ohne Buchen bis zur Obergrenze der Fichte)Nährstoffzahl NnährstoffarmKontinentalitätszahl Ksubkontinental (niedrige relative Luftfeuchtigkeit, grosse Temperaturschwankungen, eher kalte Winter)
Volksname Deutscher Name: Blutrote Fingerwurz Nom français: Orchis couleur de sang Nome italiano: Orchide sanguigna
description: Published as part of Konrad Lauber, Gerhart Wagner & Andreas Gygax, 2018, Flora Helvetica - Orchidaceae, pp. 1324-1362 in Flora Helvetica, Bern :Haupt Verlag on page 1342
Additional file 2: of Respondentsâ   report of a clinician-diagnosed depression in health surveys: comparison with DSM-IV mental disorders in the general adult population in Germany
Creators: name: Maske, Ulrike
name: Hapke, Ulfert
name: Riedel-Heller, Steffi
name: Busch, Markus
name: Kessler, Ronald
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Socio-demographic and health-related characteristics of participants who report a 12-month clinician-diagnosed depression who did or did not meet the criteria for 12-month major depressive disorder (MDD). (DOCX 25Â kb)
Public health and economic impact of COVID-19 vaccination with the Pfizer-BioNTech COVID-19 Vaccine, KP.2, among adults in 2024/2025 in the United States
Creators: name: Yehoshua, Alon
name: Di Fusco, Manuela
name: Rudolph, Abby E.
name: Thoburn, Elizabeth
name: Lopez, Santiago M.C
name: Marczell, Kinga
name: Yarnoff, Benjamin
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: To assess the public health and economic impact of vaccination with the Pfizer-BioNTech COVID-19 vaccine, KP.2, in 2024/2025 in the United States. A combined cohort Markov-decision tree model was used to estimate the cost-effectiveness and budget impact of vaccination versus no vaccination in adults aged ≥18 years. The adult population was further stratified into 18-64 years and ≥65 years age groups. Public health surveillance data informed the annual proportion of individuals infected with and vaccinated against SARS-CoV-2 and the proportion of those infected who were hospitalized, stratified by age. Other age-stratified clinical, cost, and vaccine effectiveness parameters were informed by literature. The budget impact analysis was based on a hypothetical 1-million-member plan and used a payer perspective. Parameter uncertainty was tested in sensitivity analyses. Without vaccination, the model projected 21.4 million new symptomatic cases, 15,793 deaths, 629,098 hospitalizations, $115.5 billion in total costs, and 1 million QALYs lost among adults aged ≥18 years, with the greatest health burden observed among older adults aged ≥65 years (72% of hospitalizations and 86% of deaths) and the greatest economic burden in adults aged 18–64 years (62% of total costs). Vaccination was projected to prevent 915,501 cases, 1,057 deaths, and 37,489 hospitalizations, resulting in cost savings of $513 million, 9,173 LYs gained, 56,482 QALYs gained, and a dominant ICER. In the budget impact analysis, vaccination was estimated to result in total incremental cost savings for the population aged ≥65 years and a modest budget increase for the population aged 18–64 years. Vaccination with the Pfizer BioNTech COVID-19 vaccine, KP.2, is a cost-effective measure from the societal perspective at a willingness-to-pay threshold of $50,000 that could reduce the health and economic burden of COVID-19.
Additional file 2: of Respondentsâ   report of a clinician-diagnosed depression in health surveys: comparison with DSM-IV mental disorders in the general adult population in Germany
Creators: name: Maske, Ulrike
name: Hapke, Ulfert
name: Riedel-Heller, Steffi
name: Busch, Markus
name: Kessler, Ronald
Publisher: name: Figshare
Year: 2017
Subjects: Medicine
Cell Biology
Molecular Biology
Biotechnology
Mental Health

description: Socio-demographic and health-related characteristics of participants who report a 12-month clinician-diagnosed depression who did or did not meet the criteria for 12-month major depressive disorder (MDD). (DOCX 25Â kb)
Dactylorhiza incarnata Soo
Creators: name: Konrad Lauber
name: Gerhart Wagner
name: Andreas Gygax
Publisher: name: Haupt Verlag
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Dactylorhiza
Dactylorhiza incarnata

description: Dactylorhiza incarnata (L.) Soó
Artbeschreibung: 20-60 cm hoch. Stängel hohl, unter dem Blütenstand 4-8 mm dick, mit 4-6 Blättern, oberstes den Blütenstand erreichend oder überragend. Blätter lanzettlich, vom Grund an verschmälert, stark gekielt, meist ungefleckt, Spitze kapuzenförmig. Blütenstand dicht. Tragblätter blattartig, die Blüten z.T. überragend. Lippe stark sattelförmig, von vorn gesehen ca. 2x so hoch wie breit, ausgebreitet 5-9 mm breit. Sporn horizontal oder abwärts gerichtet, 6-10 mm lang.
Ökologische Zeigerwerte nach Landolt & al. (2010)
BodenfaktorenKlimafaktorenSalztoleranzFeuchtezahl F--Lichtzahl L--Salzzeichen--Reaktionszahl R--Temperaturzahl T--Nährstoffzahl N--Kontinentalitätszahl K--
Volksname Deutscher Name: Fleischrote Fingerwurz Nom français: Orchis incarnat Nome italiano: Orchide palmata
description: Published as part of Konrad Lauber, Gerhart Wagner & Andreas Gygax, 2018, Flora Helvetica - Orchidaceae, pp. 1324-1362 in Flora Helvetica, Bern :Haupt Verlag on page 1342
Dactylorhiza incarnata subsp. incarnata
Creators: name: Konrad Lauber
name: Gerhart Wagner
name: Andreas Gygax
Publisher: name: Haupt Verlag
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Dactylorhiza
Dactylorhiza incarnata
Dactylorhiza incarnata (l.) soo subsp. incarnata

description: Dactylorhiza incarnata (L.) Soó subsp. incarnata
Artbeschreibung: Blätter straff aufrecht oder leicht zurückgebogen. Blüten rosa bis purpurn, Lippe ungeteilt oder undeutlich 3teilig, mit deutlichem Schleifenmuster.
Blütezeit: 5-6
Standort und Verbreitung in der Schweiz: Feuchte Wiesen, Flachmoore / kollin-montan(-subalpin) / CH
Verbreitung global: Eurasiatisch
Ökologische Zeigerwerte nach Landolt & al. (2010)
BodenfaktorenKlimafaktorenSalztoleranzFeuchtezahl F--Lichtzahl L--Salzzeichen--Reaktionszahl R--Temperaturzahl T--Nährstoffzahl N--Kontinentalitätszahl K--
Volksname Deutscher Name: Fleischrote Fingerwurz, Fleischfarbige Fingerwurz Nom français: Orchis incarnat Nome italiano: Orchide palmata
description: Published as part of Konrad Lauber, Gerhart Wagner & Andreas Gygax, 2018, Flora Helvetica - Orchidaceae, pp. 1324-1362 in Flora Helvetica, Bern :Haupt Verlag on page 1342
MOESM1 of Early risk factors and the role of fluid administration in developing acute respiratory distress syndrome in septic patients
Creators: name: Raghu Seethala
name: Hou, Peter
name: Imoigele Aisiku
name: Gyorgy Frendl
name: Park, Pauline
name: Mikkelsen, Mark
name: Chang, Steven
name: Gajic, Ognjen
name: Sevransky, Jonathan
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Hematology

description: Additional file 1: Table S1. Sensitivity analysis using complete case analysis (1603 total patients included). Multivariable logistic regression of early risk factors for ARDS in sepsis cohort.
Additional file 1: of Human resources for health (and rehabilitation): Six Rehab-Workforce Challenges for the century
Creators: name: Jesus, Tiago
name: Landry, Michel
name: Dussault, Gilles
name: InĂŞs Fronteira
Publisher: name: Figshare
Year: 2017
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer

description: Search strategy in PubMed. (DOCX 14 kb)
ARGOS RFI monitoring report
Creators: name: Antoniadis, John
Publisher: name: Zenodo
Year: 2024
Subjects: subject: Radio astronomy
subject: Astronomy

description: Based on the approved list of L1 specifications, the deployment of ARGOS requires a location that offers a flat plane and maximum baselines of up to 4 km, in an environment that is minimally influenced by terrestrial radio frequency interference (RFI). The main scope of this document is to report on the progress of characterising candidate sites for ARGOS.

The report presents RFI measurement results of the campaign carried out on a possible ARGOS deployment site, the Nida Plateau. The report also presents RFI measurements undertaken at the FORTH campus in Heraklion, Crete, as well as at Skinakas Observatory, to facilitate the selection a site for the installation of ARGOS pathfinder. The campaign was conducted in July 2023 by the UPRC Telecommunications System Laboratory and the two FORTH institutes, namely FORTH-IA and FORTH-ICS. Our measurements closely followed the RFI protocol described by SKA Memo 37 for the so-called Mode 1 measurements, that is, for the identification of strong RFI signals. The report concludes with a summary and evaluation these early results.
RAQAMLI VA IJTIMOIY MEDIA MARKETING VA UNING IMKONIYATLARI
Creators: name: Qodirov, Farrux
name: Eshdavlatova, Muxlisa
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqolada ijtimoiy media marketing faoliyati bilan shug’ullanishning afzalliklari va kamchiliklari, ijtimoiy media orqali mahsulot brendini keng targ‘ib qilish va xaridorlar auditoriyasini kengaytirish, ijtimoiy media marketing faoliyatiga doir asosiy tushunchalar, vazifalar hamda SMM platformalari haqidagi to‘liq ma’lumotlar yoritib berilgan. Shuningdek, mamlakatimizda SMM mutaxassislari brendni keng targ‘ib qilish, reklama berish ishlari bilan shug‘ullanishlarida ijtimoiy tarmoqlarning o‘rni haqida tushunchalar keltirilgan.
Beyond Metadata: Leveraging Similarity Search in Molecular Dynamics Data
Creators: name: Rošinec, Adrián
name: Pavlík, Tomáš
name: Slanináková, Terézia
name: Krenek, Ales
name: Špringerová, Pavlína
name: Antol, Matej
name: Svobodova, Radka
Publisher: name: Zenodo
Year: 2024

description: The exponential growth of molecular dynamics (MD) simulation data, now being standardized and shared in community-established data repositories, presents a challenge. While comprehensive metadata annotations enhance data discovery, reuse, and provide context, they are insufficient for identifying and comparing complex MD trajectories. The metadata model offers essential information about the simulation, such as system composition, simulation parameters (e.g., pressure, temperature, force field), and biomolecule identification. Although these details are valuable for categorizing and filtering datasets, they lack the granularity needed to capture the dynamic, structural, and kinetic features of molecular trajectories. As MD data continues to rise, advanced methods are needed to search, compare, and analyze these datasets beyond metadata-based approaches.

Similarity search offers a solution to address metadata limitations by enabling comparisons of molecular dynamics trajectories based on actual data rather than annotations. By identifying patterns, stable states, and characteristic motions within simulation data, similarity search can describe relationships across diverse biomolecular systems. This approach can reveal underlying mechanisms, functional similarities, or structural motifs not evident from metadata alone.

To facilitate similarity search in MD trajectories, the data must be transformed into compact, fixed-length vectors (embeddings). This transformation preserves essential information in the data, such as trajectory features, enabling efficient comparisons across biomolecular systems. Such embeddings allow the identification of common conformational states, transition pathways, and kinetic basins, supporting analyses like clustering dynamic behaviors, detection of functional motifs, and elucidating mutation impacts. These capabilities enhance applications in biomolecular function prediction, pathway analysis, and drug discovery, providing the MD community with tools for data-driven exploration.

One example of a purely data-driven search in biomolecular data is AlphaFind [1,2], which employs a learned index with compact embeddings for similarity searching within protein structures. This application demonstrates the feasibility of deep learning in biomolecular comparisons. Inspired by AlphaFind's success, we aim to explore a similar methodology with MD trajectories, where finding suitable embeddings will be crucial for capturing dynamic conformational changes. This involves developing embeddings that effectively represent the temporal and spatial features of MD trajectories, enabling efficient similarity search and deeper insights into molecular mechanisms.

[1] https://academic.oup.com/nar/article/52/W1/W182/7673488

[2] https://alphafind.fi.muni.cz/
Dactylorhiza incarnata subsp. ochroleuca P. F. Hunt & Summerh.
Creators: name: Konrad Lauber
name: Gerhart Wagner
name: Andreas Gygax
Publisher: name: Haupt Verlag
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Dactylorhiza
Dactylorhiza incarnata
Dactylorhiza incarnata subsp. ochroleuca (boll) p. f. hunt & summerh.

description: Dactylorhiza incarnata subsp. ochroleuca (Boll) P. F. Hunt & Summerh.
Artbeschreibung: Besonders obere Blätter dem Stängel eng anliegend, Blüten hellgelb, nicht gemustert, Lippe 3lappig mit nach unten geschlagenen und meist gezähnten Seitenlappen, in der Mitte dunkler gelb.
Blütezeit: 5-6
Standort und Verbreitung in der Schweiz: Kalkreiche Flachmoore und Streuwiesen / kollin / ME, MZ, VD (Villeneuve)
Verbreitung global: Mittel- und nordeuropäisch
Ökologische Zeigerwerte nach Landolt & al. (2010)
BodenfaktorenKlimafaktorenSalztoleranzFeuchtezahl Fnass; Feuchtigkeit mässig wechselnd (± 1-2 Stufen)Lichtzahl LhellSalzzeichen--Reaktionszahl Rneutral bis basisch (pH 5.5-8.5)Temperaturzahl Tunter-montan und ober-kollinNährstoffzahl NnährstoffarmKontinentalitätszahl Ksubozeanisch bis subkontinental (mittlere Luftfeuchtigkeit, mässige Temperaturschwankungen und mässig tiefe Wintertemperaturen)
Volksname Deutscher Name: Hellgelbe Fingerwurz Nom français: Orchis jaunâtre Nome italiano: Orchide bianco-gialla
description: Published as part of Konrad Lauber, Gerhart Wagner & Andreas Gygax, 2018, Flora Helvetica - Orchidaceae, pp. 1324-1362 in Flora Helvetica, Bern :Haupt Verlag on page 1342