cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Repository of the main European/international efforts to harmonise and integrate cohorts
Creators: name: Sanchez-Niubó, Albert
name: Torres, Teresa
Publisher: name: Zenodo
Year: 2020
Subjects: Repository, Harmonisation, Integration, Methods, Methodology, Infrastructures

description: The SYNCHROS repository has been created to share all key information about initiatives that harmonised and/or integrated cohort data. The repository contains information obtained from 4 different exercises: The mapping of existing initiatives that harmonised/integrated population, patient and clinical trial cohort studies The mapping of existing cohort studies assessing the impact of new exposures on health The mapping of existing population and patient cohorts using social media and new communication technologies The identification of the main European/ international efforts to harmonise and integrate cohorts The mappings 1 to 3 have been described elsewhere (Deliverable 1.3, 1.4 and 4.2, respectively), hence here we will focus on the main European / international efforts to harmonise and integrate cohorts that have been identified, and subsequently have been included in the repository. This report contains a description of the SYNCHROS repository of main European and international initiatives, and explains how data have been harmonised and integrated across different cohorts, either population, patient or clinical trial data. The document contains the following information: Description of the methodological information on harmonisation and integration collected from the identified initiatives. The state of the repository and some preliminary results of the methodological information found. Limitations and conclusions based on the experience of searching for the methodological information of the different initiatives. The repository is openly accessible at https://repository.synchros.eu/networks
description: This document was created in the context of the SYNCHROS project. SYNCHROS (SYNergies for Cohorts in Health: integrating the Role of all Stakeholders) is an EU-funded Coordination and Support Action (H2020, ref. no. 825884), aimed at developing a sustainable strategy for the integration and harmonisation of health cohort initiatives and networks across Europe and internationally. Through intensive collaboration with stakeholders (e.g. researchers, funding bodies, coordinators of cohort harmonisation and integration initiatives, policy-makers), SYNCHROS aims to create a strategic agenda for an enhanced international coordination and sustainable recommendations for better collaboration of cohorts globally, towards the development of stratified or personalised medicine.
Therapeutic Effect of Anti-CD52 Monoclonal Antibody in Multiple Sclerosis and Its Animal Models Is Mediated via T Regulatory Cells
Creators: name: Zhang, Xin
name: Wan, Yisong
name: Elzoheiry, Manal
name: Kapoor, Sahil
name: Wang, Yan
name: Kiapour, Nazanin
name: Markovic-Plese, Silva
name: Seyedsadr, Maryamsadat
name: Kasimoglu, Ezgi
name: Wu, Bing
Publisher: name: The American Association of Immunologists
Year: 2022

description: The objective of this study is to determine the mechanism of action of anti-CD52 mAb treatment in patients with relapsing-remitting multiple sclerosis (RRMS). Experimental autoimmune encephalomyelitis (EAE), an animal model of the disease, was used to address the role of T regulatory cells (Tregs) in the anti-CD52 mAb–induced suppression of the disease. In vitro studies on PBMCs from RRMS patients and matched healthy controls determined the effect of IL-7 on the expansion of CD4+CD25+CD127− Tregs and induction of their suppressive phenotype. This study using EAE animal models of MS has shown that mouse anti-CD52 mAb suppression of clinical disease was augmented by coadministration of IL-7 and partially reversed by anti-IL-7 mAb. In vitro human studies showed that IL-7 induced expansion of CD4+CD25+CD127− Tregs and increased their FOXP3, GITIR, CD46, CTLA-4, granzyme B, and perforin expression. Anti-CD52 mAb treatment of mice with relapsing-remitting EAE induced expansion of Foxp3+CD4+ Tregs and the suppression of IL-17A+CD4+ and IFN-γ+CD4+ cells in peripheral immune organs and CNS infiltrates. The effect was detected immediately after the treatment and maintained over long-term follow-up. Foxp3+CD4+ Treg-mediated suppression of IL-17A+CD4+ and IFN-γ+CD4+ cells in the spinal cord infiltrates was reversed after inducible Foxp3 depletion. Our results demonstrated that the therapeutic effect of U.S. Food and Drug Administration–approved anti-CD52 mAb is dependent on the presence of Tregs.
Extreme Secular Excitation of Eccentricity Inside Mean Motion Resonance: Driving Small Bodies into Star-Grazing Orbits by Planetary Perturbations
Creators: name: Pichierri, Gabriele
name: Morbidelli, Alessandro
name: Lai, Dong
Publisher: name: arXiv
Year: 2017
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: It is well known that asteroids and comets fall into the Sun. Metal pollution of white dwarfs and transient spectroscopic signatures of young stars like $β$-Pic provide growing evidence that extra solar planetesimals can attain extreme orbital eccentricities and fall onto their parent stars. We aim to develop a general, practically implementable, semi-analytical theory of secular eccentricity excitation of small bodies in mean motion resonances with an eccentric planet valid for arbitrary values of the eccentricities and including the short-range force due to General Relativity. Our semi-analytic model for the restricted planar three-body problem does not make use of any series expansion and therefore is valid for any values of eccentricities and semi-major axes ratios. The model is based on the application of the adiabatic principle, which is valid when the precession period of the longitude of pericenter of the planetesimal is much longer than the libration period in the mean motion resonance. This holds down to vanishingly small eccentricities in resonances of order larger than 1. We provide a Mathematica notebook with the implementation of the model allowing direct use to the interested reader. We confirm that the 4:1 mean motion resonance with a moderately eccentric planet is the most powerful one to lift the eccentricity of planetesimals from nearly circular orbits to star-grazing ones. However, if the planet is too eccentric, we find that this resonances becomes unable to pump the planetesimal's eccentricity to very high value. The inclusion of the General Relativity effect imposes a condition on the mass of the planet to drive the planetsimals into star-grazing orbits. For a planetesimal at $\sim$1 AU around a solar-mass star (or white dwarf), we find a threshold planetary mass of about 17 Earth masses. We finally derive an analytical formula for this critical mass.
description: In press in Astronomy & Astrophysics
Tonse Pamodzi: Developing a combination strategy to support adherence to antiretroviral therapy and HIV pre-exposure prophylaxis during pregnancy and breastfeeding
Creators: name: Amico, K. Rivet
name: Phanga, Twambilile
name: Mutale, Wilbroad
name: Chi, Benjamin H.
name: Tsidya, Mercy
name: Zimba, Chifundo
name: Saidi, Friday
name: Rosenberg, Nora E.
name: Chirwa, Sara
name: Maman, Suzanne
name: Hill, Lauren M.
name: Freeborn, Kellie
Publisher: name: Public Library of Science (PLoS)
Year: 2021

description: To eliminate mother-to-child transmission of HIV (EMTCT), scalable strategies to enhance antiretroviral adherence for both antiretroviral therapy (ART) and pre-exposure prophylaxis (PrEP) are needed as part of integrated HIV and maternal-child health services. We developed Tonse Pamodzi ("all of us together"), an adaptable intervention integrating biomedical and behavioral components to support HIV treatment and prevention. We describe our intervention development process, which comprised formative qualitative research, a review of the literature, and technical input from stakeholders representing the community, health systems, and policymakers. The resulting intervention, described herein, integrates patient-centered counseling and engagement of a patient-selected adherence supporter for pregnant and breastfeeding women initiating ART or PrEP. Patients receiving the intervention engage in Integrated Next Step Counseling (iNSC) sessions delivered by trained counselors to build and maintain adherence skills. Each patient also has the option of selecting an adherence supporter (partner, family member, or friend) who may participate in iNSC sessions and provide adherence support outside of these sessions. This flexible intervention is adaptable not only to ART or PrEP use, but also to the needs and preferences of each woman and the clinical context. If shown to be acceptable and feasible, the Tonse Pamodzi intervention may be an important tool in continuing efforts for EMTCT.
Additional file 3: Table S3. of Technical realization of a sensorized neonatal intubation skill trainer for operatorsâ retraining and a pilot study for its validation
Creators: name: Panizza, Davide
name: Scaramuzzo, Rosa
name: Moscuzza, Francesca
name: Vannozzi, Ilaria
name: Ciantelli, Massimiliano
name: Gentile, Marzia
name: Baldoli, Ilaria
name: Tognarelli, Selene
name: Boldrini, Antonio
name: Cuttano, Armando
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Mean pressure values scheduled for attempts in two session. We considered data with outliers exclusion. (DOCX 13Â kb)
Black hole merger simulations in wave dark matter environments
Creators: name: Bamber, Jamie
name: Aurrekoetxea, Josu C.
name: Clough, Katy
name: Ferreira, Pedro G.
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The interaction of binary black hole mergers with their environments can be studied using numerical relativity simulations. These start only a short finite time before merger, at which point appropriate initial conditions must be imposed. A key task is therefore to identify the configuration that is appropriate for the binary and its environment at this stage of the evolution. In this work we study the behaviour of wave dark matter around equal mass black hole binaries, finding that there is a preferred, quasi-stationary profile that persists and grows over multiple orbits, in contrast to heavier mass dark matter where any overdensity tends to be dispersed by the binary motion. Whilst different initial configurations converge to the preferred quasi-stationary one after several orbits, unwanted transient oscillations are generated in the process, which may impact on the signal in short simulation runs. We also point out that naively superimposing the matter onto a circular binary results in artificially eccentric orbits due to the matter backreaction, which is an effect of the initial conditions and not a signature of dark matter. We discuss the further work required so that comparison of waveforms obtained with environments to vacuum cases can be done in a meaningful way.
description: 9 pages, 5 figures, 1 appendix, 2 movies: https://youtube.com/playlist?list=PLSkfizpQDrcb8Zd7C9yEfnMpnKQk7I9ts
Additional file 11 of Comprehensive genomic characterization of NAC transcription factor family and their response to salt and drought stress in peanut
Creators: name: Yuan, Cuiling
name: Li, Chunjuan
name: Lu, Xiaodong
name: Zhao, Xiaobo
name: Yan, Caixia
name: Wang, Juan
name: Sun, Quanxi
name: Shan, Shihua
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 11. 2500 bp promoter region of NAC genes from two wild peanuts.
PTF1 J082340.04+081936.5: A hot subdwarf B star with a low mass white dwarf companion in an 87 minute orbit
Creators: name: Kupfer, Thomas
name: van Roestel, Jan
name: Brooks, Jared
name: Geier, Stephan
name: Marsh, Tom R.
name: Groot, Paul J.
name: Bloemen, Steven
name: Prince, Thomas A.
name: Bellm, Eric
name: Heber, Ulrich
name: Bildsten, Lars
name: Miller, Adam A.
name: Dyer, Martin J.
name: Dhillon, Vik S.
name: Green, Matthew
name: Irawati, Puji
name: Laher, Russ
name: Littlefair, Stuart P.
name: Shupe, David L.
name: Steidel, Charles C.
name: Rattansoon, Somsawat
name: Pettini, Max
Publisher: name: arXiv
Year: 2016
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present the discovery of the hot subdwarf B star (sdB) binary PTF1 J082340.04+081936.5. The system has an orbital period P$_{\rm orb}=87.49668(1)$ min (0.060761584(10) days), making it the second-most compact sdB binary known. The lightcurve shows ellipsoidal variations. Under the assumption that the sdB primary is synchronized with the orbit, we find a mass $M_{\rm sdB}=0.45^{+0.09}_{-0.07}$ M$_\odot$, a companion white dwarf mass $M_{\rm WD}=0.46^{+0.12}_{-0.09}$ M$_\odot$ and a mass ratio $q = \frac{M_{\rm WD}}{M_{\rm sdB}}=1.03^{+0.10}_{-0.08}$. The future evolution was calculated using the MESA stellar evolution code. Adopting a canonical sdB mass of $M_{\rm sdB}=0.47$ M$_\odot$, we find that the sdB still burns helium at the time it will fill its Roche lobe if the orbital period was less than 106 min at the exit from the last common envelope phase. For longer common envelope exit periods the sdB will have stopped burning helium and turned into a C/O white dwarf at the time of contact. Comparing the spectroscopically derived log(g) and $T_{\rm eff}$ with our MESA models, we find that an sdB model with a hydrogen envelope mass of $5\times10^{-4} M_\odot$ matches the measurements at a post-common envelope age of 94 Myr, corresponding to a post-common envelope orbital period of 109 min which is close to the limit to start accretion while the sdB is still burning helium.
description: Accepted for publication in ApJ, 9 pages, 8 figures
Toward a Better Estimation of Functional Brain Network for Mild Cognitive Impairment Identification: A Transfer Learning View
Creators: name: Li, Weikai
name: Zhang, Limei
name: Qiao, Lishan
name: Shen, Dinggang
Publisher: name: Institute of Electrical and Electronics Engineers (IEEE)
Year: 2019

description: Mild cognitive impairment (MCI) is an intermediate stage of brain cognitive decline, associated with increasing risk of developing Alzheimer's disease (AD). It is believed that early treatment of MCI could slow down the progression of AD, and functional brain network (FBN) could provide potential imaging biomarkers for MCI diagnosis and response to treatment. However, there are still some challenges to estimate a "good" FBN, particularly due to the poor quality and limited quantity of functional magnetic resonance imaging (fMRI) data from the target domain (i.e., MCI study). Inspired by the idea of transfer learning, we attempt to transfer information in high-quality data from source domain (e.g., human connectome project in this paper) into the target domain towards a better FBN estimation, and propose a novel method, namely NERTL (Network Estimation via Regularized Transfer Learning). Specifically, we first construct a high-quality network "template" based on the source data, and then use the template to guide or constrain the target of FBN estimation by a weighted l1-norm regularizer. Finally, we conduct experiments to identify subjects with MCI from normal controls (NCs) based on the estimated FBNs. Despite its simplicity, our proposed method is more effective than the baseline methods in modeling discriminative FBNs, as demonstrated by the superior MCI classification accuracy of 82.4% and the area under curve (AUC) of 0.910.
title: ADCO, Boursier de Cîteaux : comptes (1489-1493) (11 H 1166), f. 00295
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: Petot, Frédéric
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: comptes

description: Boursier de Cîteaux : comptes (1489-1493), Archives départementales de la Côte-d'Or, (11 H 1166). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Boursier de Cîteaux : comptes (1489-1493), Archives départementales de la Côte-d'Or, (11 H 1166), f. 00295, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Randomness Evaluation with the Discrete Fourier Transform Test Based on Exact Analysis of the Reference Distribution
Creators: name: Okada, Hiroki
name: Umeno, Ken
Publisher: name: arXiv
Year: 2017
Subjects: subject: Cryptography and Security (cs.CR)
subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences
subject: 94A60

description: In this paper, we study the problems in the discrete Fourier transform (DFT) test included in NIST SP 800-22 released by the National Institute of Standards and Technology (NIST), which is a collection of tests for evaluating both physical and pseudo-random number generators for cryptographic applications. The most crucial problem in the DFT test is that its reference distribution of the test statistic is not derived mathematically but rather numerically estimated, the DFT test for randomness is based on a pseudo-random number generator (PRNG). Therefore, the present DFT test should not be used unless the reference distribution is mathematically derived. Here, we prove that a power spectrum, which is a component of the test statistic, follows a chi-squared distribution with 2 degrees of freedom. Based on this fact, we propose a test whose reference distribution of the test statistic is mathematically derived. Furthermore, the results of testing non-random sequences and several PRNGs showed that the proposed test is more reliable and definitely more sensitive than the present DFT test.
description: 22 pages, 4 figures
พ่อเลี้ยงเดี่ยวในสัตว์ไม่มีกระดูกสันหลัง : เมื่อตัวผู้เท่านั้นที่มีพฤติกรรมในการดูแลลูก
Creators: name: คณิศรา แม็กนุสเซ่น
Publisher: name: กองบริหารการวิจัย
Year: 2563
Subjects: แมงโหย่ง
แมงมุมทะเล
พฤติกรรมพ่อเลี้ยงเดี่ยว

description: วารสารวิทยาศาสตร์และเทคโนโลยี, 28, 2, 331-342
Treatment-naive first episode depression classification based on high-order brain functional network
Creators: name: Zhang, Han
name: Shen, Dinggang
name: Li, Danian
name: Liang, Yi
name: Tan, Xin
name: Liu, Yujie
name: Zheng, Yanting
name: Qiu, Shijun
name: Chen, Xiaobo
Publisher: name: Elsevier
Year: 2019

description: BACKGROUND: Recent functional connectivity (FC) studies have proved the potential value of resting-state functional magnetic resonance imaging (rs-fMRI) in the study of major depressive disorder (MDD); yet, the rs-fMRI-based individualized diagnosis of MDD is still challenging. METHODS: We enrolled 82 treatment-naÃ¯ve first episode depression (FED) adults and 72 matched normal control (NC). A computer-aided diagnosis framework was utilized to classify the FEDs from the NCs based on the features extracted from not only traditional "low-order" FC networks (LON) based on temporal synchronization of original rs-fMRI signals, but also "high-order" FC networks (HON) that characterize more complex functional interactions via correlation of the dynamic (time-varying) FCs. We contrasted a classifier using HON feature (CHON) and compared its performance with using LON only (CLON). Finally, an integrated classification model with both features was proposed to further enhance FED classification. RESULTS: The CHON had significantly improved diagnostic accuracy compared to the CLON (82.47% vs. 67.53%). Joint classification further improved the performance (83.77%). The brain regions with potential diagnostic values mainly encompass the high-order cognitive function-related networks. Importantly, we found previously less-reported potential imaging biomarkers that involve the vermis and the crus II in the cerebellum. LIMITATIONS: We only used one imaging modality and did not examine data from different subtypes of depression. CONCLUSIONS: Depression classification could be significantly improved by using HON features that better capture the higher-level brain functional interactions. The findings suggest the importance of higher-level cerebro-cerebellar interactions in the pathophysiology of MDD.
Additional file 4: of Improving partnerships with family members of ICU patients: study protocol for a randomized controlled trial
Creators: name: Heyland, Daren
name: Davidson, Judy
name: Yoanna Skrobik
name: Ordons, Amanda Des
name: Scoy, Lauren Van
name: Day, Andrew
name: Vandall-Walker, Virginia
name: Marshall, Andrea
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Marine Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Baseline data collection. (DOCX 45Â kb)
Transcriptional response of human articular chondrocytes treated with fibronectin fragments: an in vitro model of the osteoarthritis phenotype
Creators: name: Reed, K.S.M.
name: Chubinskaya, S.
name: Phanstiel, D.H.
name: Loeser, R.F.
name: Kim, C.
name: Ulici, V.
Publisher: name: Elsevier
Year: 2020

description: Objective
Fibronectin is a matrix protein that is fragmented during cartilage degradation in osteoarthritis (OA). Treatment of chondrocytes with fibronectin fragments (FN-f) has been used to model OA in vitro, but the system has not been fully characterized. This study sought to define the transcriptional response of chondrocytes to FN-f, and directly compare it to responses traditionally observed in OA.
Design
Normal human femoral chondrocytes isolated from tissue donors were treated with either FN-f or PBS (control) for 3, 6, or 18 h. RNA-seq libraries were compared between time-matched FN-f and control samples in order to identify changes in gene expression over time. Differentially expressed genes were compared to a published OA gene set and used for pathway, transcription factor motif, and kinome analysis.
Results
FN-f treatment resulted in 3,914 differentially expressed genes over the time course.
Genes that are up- or downregulated in OA were significantly up- (P < 0.00001) or downregulated (P < 0.0004) in response to FN-f. Early response genes were involved in proinflammatory pathways, whereas many late response genes were involved in ferroptosis. The promoters of upregulated genes were enriched for NF-κB, AP-1, and IRF motifs. Highly upregulated kinases included CAMK1G, IRAK2, and the uncharacterized kinase DYRK3, while growth factor receptors TGFBR2 and FGFR2 were downregulated.
Conclusions
FN-f treatment of normal human articular chondrocytes recapitulated many key aspects of the OA chondrocyte phenotype. This in vitro model is promising for future OA studies, especially considering its compatibility with genomics and genome-editing techniques.
Additional file 1: Table S1. of Early versus late tracheostomy after decompressive craniectomy for stroke
Creators: name: Catalino, Michael
name: Feng-Chang Lin
name: Davis, Nathan
name: Anderson, Keith
name: Olm-Shipman, Casey
name: J. Dedrick Jordan
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology

description: Bivariate analysis for ventilator associated pneumonia. Table S2. Outcome analysis with and without tracheostomy using proposed propensity score. (DOCX 15Â kb)
Additional file 5 of Comprehensive genomic characterization of NAC transcription factor family and their response to salt and drought stress in peanut
Creators: name: Yuan, Cuiling
name: Li, Chunjuan
name: Lu, Xiaodong
name: Zhao, Xiaobo
name: Yan, Caixia
name: Wang, Juan
name: Sun, Quanxi
name: Shan, Shihua
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 5. NAC proteins of two wild peanuts.
Understanding PrEP decision making among pregnant women in Lilongwe, Malawi: A mixed-methods study
Creators: name: Tseka, Jennifer
name: Mutale, Wilbroad
name: Golin, Carol E.
name: Phanga, Twambilile
name: Maman, Suzanne
name: Chi, Benjamin H.
name: Hill, Lauren M.
name: Young, Alinda
name: Pearce, Lisa D.
name: Saidi, Friday
Publisher: name: Wiley
Year: 2022

description: INTRODUCTION: Pre-exposure prophylaxis (PrEP) is a promising tool for HIV prevention during pregnancy. With increasing rollout in antenatal settings, counselling strategies to help pregnant women make appropriate decisions about PrEP use are needed. Understanding women's motivations and concerns for PrEP use-and how these inform their decision making and feelings about the decision to start PrEP-are critical to inform these strategies. METHODS: We conducted a convergent mixed-methods study from June 2020 to June 2021 in the context of a PrEP adherence support trial among HIV-negative pregnant women in Lilongwe, Malawi. Two hundred women completed a survey reporting their motivations and concerns about PrEP use, and their feelings about the decision to start PrEP (Decisional Regret Scale). Thirty women completed in-depth interviews to better understand the decision-making process, including motivations and concerns weighed in women's decision to use PrEP. Analyses comprised descriptive and bivariate statistics, thematic qualitative analysis, and integration of quantitative and qualitative results. RESULTS: Women initiating PrEP during pregnancy were highly motivated to obtain HIV protection for themselves and their unborn child, often due to perceived HIV risk connoted by a recent sexually transmitted infection and/or concerns about partner non-monogamy. These motivations prevailed despite some concerns about safety and side effects, anticipated stigmatization, and concerns about adherence burden and pill attributes. Many women had informed their partner of their decision to use PrEP yet few felt their decision was contingent upon partner approval. Most women felt positively about the decision to start PrEP (mean decisional regret = 1.2 out of 5), but those with a greater number of concerns reported greater decisional regret (B = 0.036; p = 0.005). Furthermore, women who were specifically concerned about partner disclosure, who disliked pills or who had no perceived HIV risk reported greater decisional regret. CONCLUSIONS: Pregnant women were strongly motivated by the promise of HIV protection offered by PrEP and accepted it despite diverse concerns. A shared decision-making approach that centres pregnant women and offers partner involvement may help identify and address initial concerns about PrEP use and support prevention-effective use of PrEP during this important period.
Electrical single spin read-out using an exchange-coupled quantum dot
Creators: name: Godfrin, Clément
name: Thiele, Stefan
name: Ferhat, Karim
name: Klyatskaya, Svetlana
name: Ruben, Mario
name: Wernsdorfer, Wolfgang
name: Balestro, Franck
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We present a new way of continuously reading-out the state of a single electronic spin. Our detection scheme is based on an exchange interaction between the electronic spin and a nearby read-out quantum dot. The coupling between the two systems results in a spin-dependent conductance through the read-out dot and establishes an all electrical and non-destructive single spin detection. With conductance variations up to 4% and read-out fidelities greater than 99.5%, this method represents an alternative to systems where spin to charge conversion cannot be implemented. Using a semi-classical approach, we present an asymetric exchange coupling model in good agreement with our experimental results.
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VIII, Cart. 192 (11 H 77), 295 folios, f. 0079v
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VIII, Archives départementales de la Côte-d'Or, Cart. 192 (11 H 77), 295 folios, f. 0079v, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VIII, Archives départementales de la Côte-d'Or, Cart. 192 (11 H 77), 295 folios, f. 0079v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Completeness of Tableau Calculi for Two-Dimensional Hybrid Logics
Creators: name: Nishimura, Yuki
Publisher: name: arXiv
Year: 2022
Subjects: subject: Logic (math.LO)
subject: Logic in Computer Science (cs.LO)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences
subject: 03B60

description: Hybrid logic is one of the extensions of modal logic. The many-dimensional product of hybrid logic is called hybrid product logic (HPL). We construct a sound and complete tableau calculus for two-dimensional HPL. Also, we made a tableau calculus for hybrid dependent product logic (HdPL), where one dimension depends on the other. In addition, we add a special rule to the tableau calculus for HdPL and show that it is still sound and complete. All of them lack termination, however.
description: Version 2. 27 pages. 5 figures. This is a preprint
Understanding the effects of universal test and treat on longitudinal HIV care outcomes among South African youth: a retrospective cohort study
Creators: name: Kahn, Kathleen
name: Kabudula, Chodziwadziwa Whiteson
name: Gómez-Olivé, F. Xavier
name: Muessig, Kathryn E.
name: Lippman, Sheri A.
name: Maselko, Joanna
name: Haberland, Nicole
name: Edwards, Jessie K.
name: Filiatreau, Lindsey M.
name: Masilela, Nkosinathi
name: Dufour, Mi-Suk Kang
name: Pence, Brian W.
name: Pettifor, Audrey
Publisher: name: Springer Nature
Year: 2023

description: Introduction

Little is known about the effects of universal test and treat (UTT) policies on HIV care outcomes among youth living with HIV (YLHIV). Moreover, there is a paucity of information regarding when YLHIV are most susceptible to disengagement from care under the newest treatment guidelines. The longitudinal HIV care continuum is an underutilized tool that can provide a holistic understanding of population-level HIV care trajectories and be used to compare treatment outcomes across groups. We aimed to explore effects of the UTT policy on longitudinal outcomes among South African YLHIV and identify temporally precise opportunities for re-engaging this priority population in the UTT era.
Methods

Using medical record data, we conducted a retrospective cohort study among youth aged 18–24 diagnosed with HIV from August 2015-December 2018 in nine health care facilities in South Africa. We used Fine and Gray sub-distribution proportional hazards models to characterize longitudinal care continuum outcomes in the population overall and stratified by treatment era of diagnosis. We estimated the proportion of individuals in each stage of the continuum over time and the restricted mean time spent in each stage in the first year following diagnosis. Sub-group estimates were compared using differences.
Results

A total of 420 YLHIV were included. By day 365 following diagnosis, just 23% of individuals had no 90-or-more-day lapse in care and were virally suppressed. Those diagnosed in the UTT era spent less time as ART-naïve (mean difference=-19.3 days; 95% CI: -27.7, -10.9) and more time virally suppressed (mean difference = 17.7; 95% CI: 1.0, 34.4) compared to those diagnosed pre-UTT. Most individuals who were diagnosed in the UTT era and experienced a 90-or-more-day lapse in care disengaged between diagnosis and linkage to care or ART initiation and viral suppression.
Conclusions

Implementation of UTT yielded modest improvements in time spent on ART and virally suppressed among South African YLHIV— however, meeting UNAIDS’ 95-95-95 targets remains a challenge. Retention in care and re-engagement interventions that can be implemented between diagnosis and linkage to care and between ART initiation and viral suppression (e.g., longitudinal counseling) may be particularly important to improving care outcomes among South African YLHIV in the UTT era.
Large deviations for i.i.d. replications of the total progeny of a Galton--Watson process
Creators: name: Macci, Claudio
name: Pacchiarotti, Barbara
Publisher: name: arXiv
Year: 2017
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: The Galton--Watson process is the simplest example of a branching process. The relationship between the offspring distribution, and, when the extinction occurs almost surely, the distribution of the total progeny is well known. In this paper, we illustrate the relationship between these two distributions when we consider the large deviation rate function (provided by Cramér's theorem) for empirical means of i.i.d. random variables. We also consider the case with a random initial population. In the final part, we present large deviation results for sequences of estimators of the offspring mean based on i.i.d. replications of total progeny.
description: Published at http://dx.doi.org/10.15559/16-VMSTA72 in the Modern Stochastics: Theory and Applications (https://www.i-journals.org/vtxpp/VMSTA) by VTeX (http://www.vtex.lt/)
Additional file 2: Table S2. of Technical realization of a sensorized neonatal intubation skill trainer for operatorsâ retraining and a pilot study for its validation
Creators: name: Panizza, Davide
name: Scaramuzzo, Rosa
name: Moscuzza, Francesca
name: Vannozzi, Ilaria
name: Ciantelli, Massimiliano
name: Gentile, Marzia
name: Baldoli, Ilaria
name: Tognarelli, Selene
name: Boldrini, Antonio
name: Cuttano, Armando
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Mean times of operators scheduled for attempts in two session. (DOCX 12Â kb)
Selective sensitivity in Kerr microscopy
Creators: name: Soldatov, Ivan
name: Schäfer, Rudolf
Publisher: name: arXiv
Year: 2016
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Other Condensed Matter (cond-mat.other)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: A new technique for contrast separation in wide-field magneto-optical Kerr microscopy is introduced. Utilizing the light from eight light emitting diodes, guided to the microscope by glass fibers and being switched synchronously with the camera exposure, domain images with orthogonal in-plane sensitivity can be displayed simultaneously at real-time and images with pure in-plane or polar contrast can be obtained. The benefit of this new method of contrast separation is demonstrated for permalloy films, a NdFeB sinter magnet, and a cobalt crystal. Moreover, the new technique is shown to strongly enhance the sensitivity of Kerr microscopy by eliminating parasitic contrast contributions occurring in conventional setups. A doubling of the in-plane domain contrast and a sensitivity to Kerr rotations as low as 0.6~mdeg is demonstrated
ТРАЕКТОРИИ РАЗВИТИЯ ЦИФРОВОЙ ЭКОНОМИКИ И ДИГИТАЛИЗАЦИЯ ОБРАЗОВАНИЯ
Creators: name: ШУВАЕВ А.В.
name: ТАРАНОВА И.В.
name: ЕРМАКОВА А.Н.
name: БОГДАНОВА С.В.
Publisher: name: Московский экономический журнал
Year: 2019
Subjects: ЦИФРОВАЯ ЭКОНОМИКА
ДИГИТАЛИЗАЦИЯ
ИНФОРМАЦИОННОЕ ОБЩЕСТВО
ИНФОРМАТИЗАЦИЯ
ОБРАЗОВАНИЕ
DIGITAL ECONOMY
DIGITALIZATION
INFORMATION SOCIETY
INFORMATIZATION
EDUCATION

description: Исследованы тенденции формирования, характерные особенности и основные проблемы развития цифровой экономики в рамках современного информационного общества, определено место и роль дигитализации образования в условиях информационной экономики.
Oxidation of ascorbate by protein radicals in simple systems and in cells
Creators: name: Liu, Chia-chi
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Generation of peroxide groups in proteins exposed to a wide variety of reactive oxygen species (ROS) requires an initial formation of protein carbon-centred or peroxyl free radicals, which can be reduced to hydroperoxides. Both protein radicals and protein hydroperoxides are capable of oxidizing important biomolecules and thus initiate biological damage. In this study, we investigated the inhibition of protein hydroperoxide formation by ascorbate and GSH in gamma-irradiated HL-60 cells.--We used HL-60 cells as a model for general protection of living organisms by ascorbate (Asc) and glutathione (GSH) from the deleterious effects of protein hydroperoxides generated by radicals produced by gamma radiation. Measurement by HPLC indicated that incubation of HL-60 cells with Asc in the presence of ascorbate oxidase resulted in the accumulation of intracellular Asc. The intracellular Asc levels were lowered by irradiation, demonstrating intracellular consumption of Asc by the radiation-generated radicals. Exposure of HL-60 cells to increasing gamma irradiation doses resulted in increasing accumulation of protein peroxides in the cells. This was measured by the FOX assay. A significant decrease in intracellular protein hydroperoxides was noted when the cells were treated with ascorbic acid before irradiation. A dose-dependent protective effect of Asc was observed. Asc loading also provided strong protection from radiation-generated protein hydroperoxides independently of the composition of the external medium, showing that only the radicals formed within the cells were effective in oxidizing the cell proteins. Similarly, protein peroxidation was inhibited in cells with enhanced levels of GSH and increased when the intracellular GSH concentration was reduced. These findings indicate that ascorbate and GSH are important antioxidants in protecting cells from oxidative stress associated with the generation of protein hydroperoxide.
Brief an Johann I Bernoulli
Creators: name: Scheuchzer, Johann Jacob
Publisher: name: [s.n.]
Year: 1724

description: von Johann Jakob Scheuchzer
description: Dieser Brieftext liegt dem Brief von Johann Jakob Scheuchzer an Johann I Bernoulli von 1724.05.21, also vom gleichen Tag, bei. Es handelt sich um eine eigenhändige Kopie Scheuchzers seiner Abfertigung an Johann I Bernoulli. Diese Abfertigung wurde von Johann I Bernoulli zusammen mit seinem Brief von 1724.05.23 an Georg Bernhard Bilfinger gesandt, um diesem zu beweisen, dass der irrtümliche Abdruck von Christian Wolffs Bericht über seine Schicksale nicht von ihm, sondern von Johann Jakob Scheuchzer zu verantworten ist.
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Datenimport aus LIDOS / Bernoulli (2004-07-02)
description: Digitalisierung=Digitization=Numérisation TIFF
Giant paramagnetism induced valley polarization of electrons in charge-tunable monolayer MoSe2
Creators: name: Back, Patrick
name: Sidler, Meinrad
name: Cotlet, Ovidiu
name: Srivastava, Ajit
name: Takemura, Naotomo
name: Kroner, Martin
name: Imamoglu, Atac
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: For applications exploiting the valley pseudospin degree of freedom in transition metal dichalcogenide monolayers, efficient preparation of electrons or holes in a single valley is essential. Here, we show that a magnetic field of 7 Tesla leads to a near-complete valley polarization of electrons in MoSe2 monolayer with a density 1.6x10^{12} cm^{-2}; in the absence of exchange interactions favoring single-valley occupancy, a similar degree of valley polarization would have required a pseudospin g-factor exceeding 40. To investigate the magnetic response, we use polarization resolved photoluminescence as well as resonant reflection measurements. In the latter, we observe gate voltage dependent transfer of oscillator strength from the exciton to the attractive-Fermi-polaron: stark differences in the spectrum of the two light helicities provide a confirmation of valley polarization. Our findings suggest an interaction induced giant paramagnetic response of MoSe2, which paves the way for valleytronics applications.
ВЛИЯНИЕ СЕЛЬСКОХОЗЯЙСТВЕННОГО ИСПОЛЬЗОВАНИЯ ЗЕМЕЛЬ НА ВОДОСБОРЕ ВОДОХРАНИЛИЩ КАНАЛА ИМ. МОСКВЫ НА СОДЕРЖАНИЕ ПОДВИЖНЫХ ФОРМ ЭЛЕМЕНТОВ В ПОЧВЕННОМ ПРОФИЛЕ
Creators: name: ГРУЗДЕВ ВЛАДИМИР СТАНИСЛАВОВИЧ
name: СУСЛОВ СЕРГЕЙ ВЛАДИМИРОВИЧ
name: ХРУСТАЛЁВА МАРИЯ АНТОНОВНА
Publisher: name: Московский экономический журнал
Year: 2019
Subjects: ПОЧВА
БИОГЕННЫЕ ЭЛЕМЕНТЫ
МИГРАЦИЯ
АККУМУЛЯЦИЯ
ЛАНДШАФТ
SOIL
BIOGENIC ELEMENTS
MIGRATION
ACCUMULATION
LANDSCAPE

description: Изучение особенностей передвижения¸ аккумуляции химических элементов в компонентах ландшафтов, а так же техногенных источников их поступления, позволяет прогнозировать изменение компонентов ландшафтов при развитии территорий и соответственном изменении количества поступающих элементов. Одним из таких источников подвижных форм биогенных элементов служит сельское хозяйство, применение высоких норм химических удобрений для обеспечения урожайности культур. В статье сравниваются содержания подвижных форм азота, фосфора, калия в прочвах различных ландшафтов на водосборе Пестовского и Учинского водохранилищ
Treatment of immune thrombocytopenia with hetrombopag olamine tablets in a Kabuki syndrome patient with new KMT2D mutations
Creators: name: Peng, Peng
name: Pan, Ying
name: Lu, Xueqing
name: Xu, Hui
name: Zhou, Ziwei
name: He, Yuanqing
name: Wang, Huiru
name: Zheng, Changcheng
name: Zhou, Li
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mental Health
subject: Virology

description: Kabuki syndrome (KS) is a rare multisystem-affecting genetic disorder, and usually accompanied with autoimmune disorders such as immune thrombocytopenic purpura (ITP). Here, we report a 16-year-old patient with Kabuki syndrome with ITP and observe the therapeutic effect of TPO agonist hetrombopag olamine tablets. The duration of maintenance therapy and follow up were both 17 months. Whole exon sequencing (WES) of the patient’s peripheral blood showed c.5775_5778del (p. Leu1926LysfsTer120) heterozygous mutation in the KMT2D gene, which was not reported before.
Additional file 1 of Insight into blood pressure targets for universal coverage of hypertension services in Iran: the 2017 ACC/AHA versus JNC 8 hypertension guidelines
Creators: name: Mahdavi, Mahdi
name: Parsaeian, Mahboubeh
name: Mohajer, Bahram
name: Modirian, Mitra
name: Ahmadi, Naser
name: Yoosefi, Moein
name: Mehdipour, Parinaz
name: Djalalinia, Shirin
name: Rezaei, Nazila
name: Haghshenas, Rosa
name: Pazhuheian, Forough
name: Madadi, Zahra
name: Sabooni, Mahdi
name: Razi, Farideh
name: Samiee, Siamak Mirab
name: Farzadfar, Farshad
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Cancer

description: Additional file 1: Complementary analysis of relationships between daily salt intake and the outcomes. Table S1. Prevalence of hypertension based on the 2017 ACC/AHA and JNC8 hypertension guidelines and individual characteristics associated with prevalence according to the 2017 ACC/AHA guideline. Table S2. Percentage of hypertension awareness based on the 2017 ACC/AHA and JNC8 hypertension guidelines and individual characteristics associated with awareness according to the 2017 ACC/AHA guideline. Table S3. Percentage of hypertension treatment based on the 2017 ACC/AHA and JNC8 hypertension guidelines and individual characteristics associated with treatment according to the 2017 ACC/AHA guideline. Table S4. Percentage of hypertension control based on the 2017 ACC/AHA and JNC8 hypertension guidelines and individual characteristics associated with hypertension control according to the 2017 ACC/AHA guideline.
Weighted graph regularized sparse brain network construction for MCI identification
Creators: name: Qiao, Lishan
name: Chen, Mingming
name: Yu, Renping
name: Lee, Seong-Whan
name: Fei, Xuan
name: Shen, Dinggang
Publisher: name: Elsevier
Year: 2019

description: Brain functional networks (BFNs) constructed from resting-state functional magnetic resonance imaging (rs-fMRI) have been widely applied to the analysis and diagnosis of brain diseases, such as Alzheimer's disease and its prodrome, namely mild cognitive impairment (MCI). Constructing a meaningful brain network based on, for example, sparse representation (SR) is the most essential step prior to the subsequent analysis or disease identification. However, the independent coding process of SR fails to capture the intrinsic locality and similarity characteristics in the data. To address this problem, we propose a novel weighted graph (Laplacian) regularized SR framework, based on which BFN can be optimized by considering both intrinsic correlation similarity and local manifold structure in the data, as well as sparsity prior of the brain connectivity. Additionally, the non-convergence of the graph Laplacian in the self-representation model has been solved properly. Combined with a pipeline of sparse feature selection and classification, the effectiveness of our proposed method is demonstrated by identifying MCI based on the constructed BFNs.
Additional file 3: of Improving partnerships with family members of ICU patients: study protocol for a randomized controlled trial
Creators: name: Heyland, Daren
name: Davidson, Judy
name: Yoanna Skrobik
name: Ordons, Amanda Des
name: Scoy, Lauren Van
name: Day, Andrew
name: Vandall-Walker, Virginia
name: Marshall, Andrea
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology

description: Eligibility criteria. (DOCX 45Â kb)