cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Pharmacophore-based virtual screening, synthesis, biological evaluation, and molecular docking study of novel pyrrolizines bearing urea/thiourea moieties with potential cytotoxicity and CDK inhibitory activities
Creators: name: Shawky, Ahmed M.
name: Ibrahim, Nashwa A.
name: Abourehab, Mohammed A. S.
name: Abdalla, Ashraf N.
name: Gouda, Ahmed M.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: In the current study, virtual screening of a small library of 1302 pyrrolizines bearing urea/thiourea moieties was performed. The top-scoring hits were synthesised and evaluated for their cytotoxicity against three cancer (MCF-7, A2780, and HT29) and one normal (MRC-5) cell lines. The results of the MTT assay revealed potent cytotoxic activities for most of the new compounds (IC50 = 0.16–34.13 μM). The drug-likeness study revealed that all the new compounds conform to Lipinski’s rule. Mechanistic studies of compounds 18 b, 19a, and 20a revealed the induction of apoptosis and cell cycle arrest at the G1 phase in MCF-7 cells. The three compounds also displayed potent inhibitory activity against CDK-2 (IC50 = 25.53–115.30 nM). Moreover, the docking study revealed a nice fitting of compound 19a into the active sites of CDK-2/6/9. These preliminary results suggested that compound 19a could serve as a promising scaffold in the discovery of new potent anticancer agents. HighlightsVirtual screening of 1302 pyrrolizines was done using the pharmacophore model of the multi-CDKI 3.The top-scoring hits were synthesised and evaluated for their cytotoxic activities.Compound 19a showed potent in vitro cytotoxic activity against CDK-2.Compound 19a induced apoptosis and cell cycle arrest at the G1 phase in MCF-7 cells.The docking study revealed nice fitting of compound 19a into CDK-2/6/9 with high binding affinities. Virtual screening of 1302 pyrrolizines was done using the pharmacophore model of the multi-CDKI 3. The top-scoring hits were synthesised and evaluated for their cytotoxic activities. Compound 19a showed potent in vitro cytotoxic activity against CDK-2. Compound 19a induced apoptosis and cell cycle arrest at the G1 phase in MCF-7 cells. The docking study revealed nice fitting of compound 19a into CDK-2/6/9 with high binding affinities.
Processing and characterization of Z-Ta4C3-x: a high toughness tantalum carbide
Creators: name: Sygnatowicz, Michael M.
Publisher: name: University of Utah
Year: 2015
Subjects: Crack-bridging
High fracture toughness
Hydrogenation
Lamella
Rising R-curve
Tantalum carbide

description: Tantalum carbides are commonly processed by hot-pressing, canned hot-isostaticpressing, or spark-plasma sintering because of their high melting temperatures and low diffusivities. This study reports processing of dense Z-Ta4C3-x by reaction sintering of a Ta and TaC powder mixture (C/Ta atomic ratio = 0.66). Z-Ta4C3-x is of interest due to its rhombohedral (trigonal) crystal structure that may be characterized as a polytype with both face-centered-cubic (fcc) and hexagonal-close-packed (hcp) Ta stacking sequences interrupted by stacking faults and missing carbon layers. This structure leads to easy cleaving on the basal planes and high fracture toughness. A key step in processing is the hydrogenation of the Ta powder to produce PTaHx, a hard and brittle phase that enables efficient comminution during milling and production of small, equiaxed Ta particles that can be packed to high green density with the TaC powder. Studies of phase evolution by quantitative X-ray diffraction during sintering revealed several intermediate reactions: (a) decomposition of P-TaHx to Ta, (b) diffusion of C from y-TaC to Ta leading to the formation of a-Ta2Cy' with the kinetics described by the Johnson-Mehl-Avrami-Kolmogorov (JMAK) equation with an exponent, n = 0.5, and an activation energy of 221 kJ/mole, (c) equilibration of a-Ta2Cy' and Y-TaC078 phases, and (d) formation of Z-Ta4C256 from the equilibrated a-Ta2C and y-TaC0 78 phases with the kinetics characterized by a higher JMAK exponent (n « 3) and higher activation energy (1089 kJ/mole). The microstructure showed evidence of nucleation and growth of the Z-Ta4C2.56 phase in both the a-Ta2C and y-TaC0.78 parent phases with distinct difference in the morphology due to the different number of variants of the habit plane. A hot-pressed and hot-isostatic-pressed (HIPed) material (C/Ta atomic ratio = 0.66), having formed 95 w% Z-phase, attained a fracture toughness of 15.6 ± 0.5 MPaVm and a fracture strength of 508 ± 97 MPa, while a pressureless sintered and HIPed counterpart, having formed 89 w% Z-phase and 11 w% y-TaC0 78, attained a fracture toughness of 13.7 ± 0.3 MPaVm and a fracture strength of 679 ± 56 MPa. All Z-phase containing materials showed rising R-curves. The high fracture toughness and rising Rcurve were attributed to ligament bridging across the crack face. The ligaments, called lamella, were formed as a result of weak cleavage planes in the basal plane of the QTa4C3-x crystal.
Cyclocephala hardyi Endrodi 1975
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala hardyi

description: Cyclocephala hardyi Endrödi, 1975
Cyclocephala hardyi Endrödi 1975a: 281 (Brazil)
Distribution. Guyana: Seymour and Matthews 2006: 1130; Moore et al. 2018b: 184. Brazil (NA): Endrödi 1975a: 281, 1985a: 45, 126; Prance and Arias 1975: 126; Andreazze and Fonseca 1998: 61 (NA); Joly 2000: 526; Moore et al. 2018b: 184.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 171, DOI: 10.5281/zenodo.3678492
[Porträt des Heinrich Wölfflin zusammen mit Robert von Planta in familiärer Runde]
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1924
Subjects: Porträtfotografie
Wölfflin, Heinrich1864-1945

description: Name der abgelichteten Personen, Ort der Aufnahme sowie Datierung gemäss handschriftlicher Notiz auf der Rückseite des Abzugs
description: Unbekannte/r Fotograf/in
[Porträt des Heinrich Wölfflin zusammen mit Heinrich Lüders in Bergün]
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1935
Subjects: Porträtfotografie
Wölfflin, Heinrich1864-1945
Lüders, Heinrich1869-1943

description: Namen der abgelichteten Personen gemäss handschriftlicher Notiz auf der Rückseite des Abzuges
description: Ort der Aufnahme gemäss handschriftlicher Notiz auf der Rückseite des Abzuges
description: Unbekannte/r Fotograf/in
4-Arylthiosemicarbazide derivatives as a new class of tyrosinase inhibitors and anti-Toxoplasma gondii agents
Creators: name: Bekier, Adrian
name: Węglińska, Lidia
name: Paneth, Agata
name: Paneth, Piotr
name: Dzitko, Katarzyna
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: We report herein anti-proliferation effects of 4-arylthiosemicarbazides, with a cyclopentane substitution at N1 position, on highly virulent RH strain of Toxoplasma gondii. Among them, the highest in vitro anti-Toxoplasma activity was found with the meta-iodo derivative. Further experiments demonstrated inhibitory effects of thiosemicarbazides on tyrosinase (Tyr) activity, and good correlation was found between percentage of Tyr inhibition and IC50Tg. To confirm the concept that thiosemicarbazides are able to disrupt tyrosine metabolism in Toxoplasma tachyzoites, the most potent Tyr inhibitors were tested for their efficacy of T. gondii growth inhibition. All of them significantly reduced the number of tachyzoites in the parasitophorous vacuoles (PVs) compared to untreated cells, as well as inhibited tachyzoites growth by impeding cell division. Collectively, these results indicate that compounds with the thiosemicarbazide scaffold are able to disrupt tyrosine metabolism in Toxoplasma tachyzoites by deregulation of their crucial enzyme tyrosine hydroxylase (TyrH).
Cyclocephala immaculata
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala immaculata

description: Cyclocephala immaculata (Olivier, 1789)
Melolontha immaculata Olivier 1789: 29
Note. Two presently recognized subspecies of Cyclocephala immaculata have been described, one of which occurs in the research area. The other one is C. immaculata immaculata (Olivier, 1789) (recorded from West Indies).
Subspecies Cyclocephala immaculata ferruginea (Fabricius, 1798)
Melolontha ferruginea Fabricius 1798: 131 (French Guiana - LECTOTYPE)
Distribution. French Guiana: Fabricius 1798: 131 (as Melolontha ferruginea); Endrödi 1966a: 197 (designation LECTOTYPE Melolontha ferruginea), 1985a: 101; Duranton 2011: 13 (?); Ponchel 2011: 60; Dupuis 2016b: 109; Moore et al. 2018b: 188. “Guianas”: Arrow 1937b: 10 (as C. ferruginea); Blackwelder 1944: 251 (as C. ferruginea).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 171, DOI: 10.5281/zenodo.3678492
[Porträt der Familie Thurneysen-Merian]
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1870
Subjects: Porträtfotografie
Thurneysen, Rudolf1857-1940
Thurneysen-Merian, Elisa1825-1900

description: Familienporträt, abgelichtet sind (stehend, von links nach rechts): Rudolf Thurneysen-Merian, unbekannt, Peter Thurneysen-Merian, Elisa Thurneysen-Merian; (sitzend, von links nach rechts): Cécile Thurneysen-Merian und Elisa Merian
description: N. Strübin
description: Abzug auf eine Kabinettkarte montiert
description: Titel und namen der abgelichteten Personen gemäss handschriftlicher Notiz auf der Rückseite der Kabinettkarte
Using a bimodal size distribution to retrieve marine low cloud properties using A-Train satellite and ground data
Creators: name: West, Tyler K.
Publisher: name: University of Utah
Year: 2014
Subjects: ARM
A-Train
Azores
Clouds
Marine boundary layer
Microphysics

description: Understanding the connection between large-scale meteorology, cloud macrophysical variables, and cloud microphysical variables is needed in order to improve the parameterization of marine boundary layer (MBL) clouds in weather and climate models. For this study, multiple aspects of MBL clouds over the Atmospheric Radiation Measurement Program (ARM) mobile site at Graciosa Island, Azores are examined. Hourly averaged raw variables of cloud fraction, column summed dBZ, liquid water path, first cloud base height, boundary layer static stability, and midtropospheric static stability are clustered together using a K-means clustering algorithm. The cluster output infers seven characteristic cloud regimes that describe the spectrum of warm boundary layer clouds that occurred over Graciosa Island during the deployment. These cloud regimes range from precipitating stratocumulus to nonprecipitating fair weather cumulus to deep clouds associated with broad synoptic scale frontal systems. Using the cluster results and NCEP/NCAR reanalysis, the typical macrophysical and meteorological environments for the MBL cloud regimes are summarized along with their average radar profiles. MBL cloud microphysical properties are then derived using a new retrieval algorithm that assumes the presence of both cloud and precipitation particle modes within a radar resolution volume. Compared to a traditional single mode particle size distribution (PSD), a bimodal PSD is closer to in-situ observations and is expected to provide improved statistics and understanding of the cloud microphysical parameters such as number concentration, precipitation rate, and effective droplet sizes. The bimodal retrieval algorithm can use either ARM ground-based or A-Train satellite-based data as an input. This study finds that ARM and A-Train versions of the bimodal algorithm retrieve plausible microphysics and the reasons for their differences are explored. Case studies are completed using the bimodal retrieval for three shallow cloud regimes with varying precipitation, macrophysical, and synoptic environments. Results show that microphysical quantities do change as the cloud regime varies and validate the connection between the large and small-scale environment of MBL clouds. The specifics of the unique regime-based microphysics are also useful in order to better parameterize these clouds in models.
Molecular design and chemical synthesis of affinity probes for lysophosphatidic acid receptors
Creators: name: Qian, Lian
Publisher: name: University of Utah
Year: 2012
Subjects: Ovarian Neoplasms

description: Lysophosphatidic acid (LPA) is an important phospholipid that mediates a variety of biologic effects. LPA induces cell proliferation, morphological changes, and has been shown to be involved in many pathophysiological processes including cancers, immunological diseases, and cardiovascular diseases and wound healing. LPA accomplishes its biological activities by acting mainly upon G-protein coupled receptors. These receptors exist in most of mammalian cells and each receptor's functions are still not clear. Thus, development of approaches to modify LPA function could have broad applicability in the control and improvement of pathophysiological conditions.  LPA is present in ascites from ovarian cancer patients at very high concentrations, and it plays an essential role in regulating drug sensitivity and invasiveness of ovarian cancer cells. The development of antibodies against LPA has the potential to improve the diagnosis and treatment of ovarian cancer. In the first study, I synthesized lipid immunogens as bioconjugates with different linkers and carriers for preparation of specific antisera. A LPA/PA cross-reactive murine IgG mAb was generated, which will be useful to selectively extract LPA and PA molecular species from human serum.  In a separate study, I synthesized a series of long-lived and metabolically stabilized LPA analogues. Hydroxyethoxy (HE)-substituted LPA derivatives selectively activated the LP A3 receptor, but with a potency tenfold lower than natural oleoyl LPA. A methyl thiophosphate LPA analogue, OMPT (l-oleoyl-2-O-methyl-rflc-glycero-phosphothioate), showed enantioselective responses to LPA3 receptor, and a highly potent and selective LP A3 receptor agonist (2.S)-0MPT was discovered. Among a group of thiophosphate LPA analogues with ether chains, two phosphodiesters, LQIO and LQll, were found to act as antagonists to inhibit the stimulatory effects of LPA-mediated signaling on DNA synthesis in cells. The synthesis of these compounds provides tremendous insight into how LPA receptor antagonists with high potency and less toxicity can be generated as potential therapeutics for the treatment of ovarian cancer.
Moratória da Dívida Pública: o não Dever e o não Poder
Creators: name: Rocha, Alexandre
Publisher: name: figshare
Year: 2020
Subjects: subject: 160509 Public Administration
subject: FOS: Political science

description: O texto discorre sobre os empecilhos jurídicos (o “não dever”) e econômico-financeiros (o “não poder”) para a decretação de uma moratória da dívida pública brasileira. [Terraço Econômico]
Cyclocephala kahanoffae Martinez 1975
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala kahanoffae

description: Cyclocephala kahanoffae Martínez, 1975
Cyclocephala kahanoffae Martínez 1975: 270 (Brazil)
= Cyclocephala tarsalis Dechambre 1979c: 166 (Brazil) - Dupuis and Bosia 2016: 84 (syn. nov.)
Distribution. Suriname: MHCN - NEW COUNTRY RECORD (Suriname, Brokopondo, Brownsberg NP, (4°56′55″N, 55°10′55″W), ± 500m. 13/ 20-VIII-2015. M. A. Hielkema. On HPL.). French Guiana: Brûlé et al. 2011a: 191 (as C. tarsalis), 2014: 181 (as C. tarsalis); Duranton 2011: 15 (as C. tarsalis); Ponchel 2011: 60 (as C. tarsalis); Dupuis and Bosia 2016: 84; Dupuis 2016b: 109; Moore et al. 2018b: 254 (as C. tarsalis). Brazil: Martínez 1975: 270; Dechambre 1979c: 166 (as C. tarsalis); Endrödi 1985a: 69, 731 (as C. kahanoffae; as C. tarsalis); Dupuis and Bosia 2016: 84; Moore et al. 2018b: 191, 254 (as C. kahanoffae; as C. tarsalis).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 171, DOI: 10.5281/zenodo.3678492
Stelze s/l Dieter z. fr. Er
Creators: name: Höflinger, Jakob
Publisher: name: [s.n.]
Year: 1879
Subjects: Porträtfotografie
Fininger, Leonhard1861-1947

description: Porträt der beiden Studenten Leonhard Finiger (links) und Charles Daniel Bourcart (rechts) im Couleur der Paedagogia Basiliensis
description: J. Höflinger
description: Abzug auf eine Kabinettkarte montiert
description: Titel und Datierung gemäss handschriftlichem Widmungstext auf der Rückseite der Kabinettkarte
description: Verbindungszirkel auf der Rückseite der Kabinettkarte
Characterization and function of metal ion clusters in metallothionein and metallothionein-like proteins
Creators: name: Jensen, Laran T.
Publisher: name: University of Utah
Year: 2012
Subjects: Yeast
Copper-Binding

description: Metal ions can interact with specific biological molecules and activate or regulate the function of these molecules by causing a change in molecular structure. Metallothioneins (MTs) are small, cysteine rich proteins that bind metal ions tenaciously. Metal ions are chelated within polymetallic clusters and undergo facile metal exchange reactions. MTs appear to function in metal ion regulation and detoxification. Metallothionein-3 (MT-3) is a brain specific member of the metallothionein family of metal binding proteins, and its absence has been implicated in the development of Alzheimer's disease (AD). The growth inhibitory activity of MT-3 appears to result from a distinct amino acid sequence and not unusual metal-binding properties compared with MT-1 or MT-2.  The transcription factor Macl from S. cerevisiae regulates the expression of the high affinity copper uptake system in a copper dependent manner. When cells are exposed to copper concentration above starvation levels expression of genes in this uptake system is inhibited. Macl contains two cysteine rich motifs in the C-terminus which resemble Cu(I) binding cysteinyl sequences found in MTs. Macl was found to directly bind Cu(I) ions and a copper dependent intramolecular interaction between the N-terminal DNA binding domain and the C-terminal copper binding activation domain was identified. This interaction may result in the masking of the DNA binding domain in a copper dependent manner abolishing expression of Macl regulated genes.  In yeast, MT genes are transcriptionally induced by copper, but not by other metal ions.   The primary copper buffering protein in S.  cerevisiae is a MT
[Porträt der Geschwister Rudolf, Max und Alfred Goenner]
Creators: name: Höflinger, August
Publisher: name: [s.n.]
Year: 1895
Subjects: Porträtfotografie
Gönner, Rudolf1889-1918
Goenner, Alfred Adolf1885-1929

description: August Höflinger
description: Abzug auf eine Kabinettkarte montiert
description: Namen der abgelichteten Personen gemäss handschriftlicher Notiz auf der Rückseite der Kabinettkarte
Herr Prof. A. Goenner mit Hélène
Creators: name: Höflinger, August
Publisher: name: [s.n.]
Year: 1892
Subjects: Porträtfotografie
Goenner, Alfred1854-1940

description: August Höflinger
description: Titel gemäss handschriftlicher Notiz auf der Rückseite der Kabinettkarte
description: Abzug auf eine Kabinettkarte montiert
Cyclocephala kuntzeniana Hohne 1923
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala kuntzeniana

description: Cyclocephala kuntzeniana Höhne, 1923
Cyclocephala kuntzeniana Höhne 1923b: 366 (Brazil - LECTOTYPE)
Distribution. Suriname: Dechambre 1979c: 164; Moore et al. 2018b: 192. French Guiana: Brûlé et al. 2011a: 191, 2014: 181; Duranton 2011: 13; Ponchel 2011: 60; Dupuis 2016b: 109; Moore et al. 2018b: 192. Brazil: Höhne 1923b: 366; Arrow 1937b: 11; Blackwelder 1944: 251; Endrödi 1966a: 227 (designation LECTOTYPE Cyclocephala kuntzeniana), 1985a: 81, 120; Martínez 1975: 263; Dechambre 1979c: 164; Lachaume 1992: 14; Moore et al. 2018b: 192. Venezuela: Martínez 1975: 263; Moore et al. 2018b: 192. Other: Endrödi 1966a: 227 (Bolivia, Colombia), 1985a: 81, 120 (Bolivia, Colombia); Martínez 1975: 263 (Bolivia, Colombia); Dechambre 1979c: 164 (Bolivia, Colombia); Lachaume 1992: 14 (Bolivia, Colombia); Moore et al. 2018b: 192 (Bolivia, Colombia).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 171, DOI: 10.5281/zenodo.3678492
title: Memoria 2000
Creators: name: Universidad Especializada de las Américas, UDELAS
Publisher: name: Universidad Especializadas de las Américas
Year: 2019
Subjects: subject: FOS: Educational sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Dos hechos esenciales caracterizan la memoria de este período, los cuales justifican y fundamentan la historia en este centro de enseñanza y formación profesional de nivel universitario. El primero está determinado por el conjunto de acciones que permitieron incrementar nuestro abanico de opciones educativas y con ello la ampliación de nuestra cobertura a otras provincias regiones. El segundo presenta el conjunto de decisiones y acciones que se han emprendido para proceder a desarrollar toda la Ley 40 y el Estatuto Orgánico que crea y reglamenta la UDELAS en su carácter y función eminentemente educativa, social y comunitaria.
[Porträt der beiden Studenten Ernst Vonder Mühll und Otto Zellweger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1878
Subjects: Porträtfotografie
Zellweger, Otto1858-1933

description: J. Jungmann
description: Abzug auf Kabinettkarte montiert
description: Namen der abgelichteten Personen gemäss handschriftlicher Notiz auf der Rückseite der Kabinettkarte
Continuum description of the time- and strain-dependent Poisson's ratio of ligament under finite deformation
Creators: name: Swedberg, Aaron
Publisher: name: University of Utah
Year: 2015
Subjects: Constitutive model
Finite element analysis
Ligament
Poisson's ratio
Tendon

description: Ligaments and tendons undergo volume loss when stretched along the primary fiber axis, which is evident by the large, strain-dependent Poisson's ratios measured during quasistatic tensile tests. When continuum constitutive models have been used to describe ligament material behavior they have generally assumed incompressibility, which does not reflect the volume loss seen experimentally. We developed a strain energy equation that can predict both the nonlinear, transversely isotropic behavior as well as the large, strain-dependent Poisson's ratios seen experimentally. This hyperelastic constitutive model was implemented in the finite element solver FEBio and the quasistatic and time-dependent material behaviors were compared to a nearly incompressible constitutive model. The new model was able to predict uniaxial stress-strain behavior comparable to the nearly incompressible model and successfully predicted a large, strain-dependent Poisson's ratio. Biphasic simulations that represented the solid phase with the constitutive model predicted a large outward fluid flux and substantial stress-relaxation, suggesting that the viscoelastic behavior of ligaments and tendons can be predicted by modeling fluid movement when combined with a large Poisson's ratio.
HT-SuMD: making molecular dynamics simulations suitable for fragment-based screening. A comparative study with NMR
Creators: name: Ferrari, Francesca
name: Bissaro, Maicol
name: Fabbian, Simone
name: De Almeida Roger, Jessica
name: Mammi, Stefano
name: Moro, Stefano
name: Bellanda, Massimo
name: Sturlese, Mattia
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Fragment-based lead discovery (FBLD) is one of the most efficient methods to develop new drugs. We present here a new computational protocol called High-Throughput Supervised Molecular Dynamics (HT-SuMD), which makes it possible to automatically screen up to thousands of fragments, representing therefore a new valuable resource to prioritise fragments in FBLD campaigns. The protocol was applied to Bcl-XL, an oncological protein target involved in the regulation of apoptosis through protein–protein interactions. Initially, HT-SuMD performances were validated against a robust NMR-based screening, using the same set of 100 fragments. These independent results showed a remarkable agreement between the two methods. Then, a virtual screening on a larger library of additional 300 fragments was carried out and the best hits were validated by NMR. Remarkably, all the in silico selected fragments were confirmed as Bcl-XL binders. This represents, to date, the largest computational fragments screening entirely based on MD.
Cyclocephala laminata Burmeister 1847
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala laminata

description: Cyclocephala laminata Burmeister, 1847
Cyclocephala laminata Burmeister 1847: 57 (Brazil - LECTOTYPE)
Distribution. Guyana: Endrödi 1966a: 229; Dechambre 1979c: 164; Moore et al. 2018b: 194. Suriname: Endrödi 1966a: 229; Moore et al. 2018b: 194; MHCN; NZCS. French Guiana: Endrödi 1966a: 229; Dechambre 1979c: 164; Duranton 2011: 13; Ponchel 2011: 60; Dupuis 2016b: 109; Moore et al. 2018b: 194. Brazil: Burmeister 1847: 57; Arrow 1937b: 11; Blackwelder 1944: 251; Endrödi 1966a: 229 (designation LECTOTYPE Cyclocephala laminata); Dechambre 1979c: 164; Moore et al. 2018b: 194. Other: Blackwelder 1944: 251 (Argentina); Endrödi 1966a: 229 (Argentina, Bolivia, Colombia, Costa Rica, Mexico, Panama, Paraguay, Peru, Puerto Rico, U.S.A.), 1985a: 103, 147 (Argentina–U.S.A.); Dechambre 1979c: 164 (Argentina, Bolivia, Central America, Colombia, Mexico, Paraguay, Peru, Puerto Rico, U.S.A.); Moore et al. 2018b: 194 (Argentina, Bolivia, Colombia, Guatemala, Mexico, Paraguay, Peru, U.S.A.).
Note. According to Endrödi (1966a: 229, 1985a: 103, 147) and Dechambre (1979c: 164), Cyclocephala laminata is distributed from the U.S.A. to Argentina. According to Ratcliffe (2003: 225), the records from Central America, Mexico and the U.S.A. are incorrect, as this is a South American species.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 172, DOI: 10.5281/zenodo.3678492
[Porträt der Margaretha Hagenbach-Bischoff mit ihrem Sohn Karl]
Creators: name: Magnat Frères
Publisher: name: [s.n.]
Year: 1865
Subjects: Porträtfotografie

description: Magnat Frères
description: Abzug auf eine Kabinettkarte montiert
description: Namen der abgelichteten Personen gemäss handschriftlicher Notiz auf der Rückseite der Kabinettkarte
Herr und Frau Kern-Alioth
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1895
Subjects: Porträtfotografie
Alioth, Mathilde1863-1948

description: Emil und Mathilde Kern-Alioth auf einer Parkbank sitzend
description: Unbekannte/r Fotograf/in
description: Titel gemäss handschriftlicher Notiz auf der Rückseite des Abzugs
Cyclocephala lichyi Dechambre 1980
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala lichyi

description: § Cyclocephala lichyi Dechambre, 1980
Cyclocephala lichyi Dechambre 1980: 46 (Venezuela (EO))
Distribution. Venezuela (EO): Dechambre 1980: 46 (EO); Endrödi 1985a: 733; Moore et al. 2018b: 196 (EO).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 172, DOI: 10.5281/zenodo.3678492
title: Memoria 2021
Creators: name: Universidad Especializada de las Américas
Publisher: name: Universidad Especializadas de las Américas
Year: 2022
Subjects: subject: FOS: Educational sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: El año 2021 se caracterizó por logros importantes para la UDELAS, pese a las condiciones adversas que impuso la pandemia. Igual que en el 2020, la presencia de la situación inédita de la COVID-19 que, por razones de bioseguridad, provocó una suspensión total de las actividades económicas y sociales, y, en el caso de la educación, obligó a un cambio drástico de su modalidad de enseñanza presencial a la no presencial o virtual. Con la llegada de las vacunas y de su progresiva aplicación a un gran porcentaje de la población, hacia mediados del año 2021, la cantidad de población infectada y de defunciones disminuyó a niveles que permitieron, en el último trimestre la reapertura de un amplio número de las actividades económicas y sociales.
[Porträt ders Hans Georg Stehlin zusammen mit seiner Schwester Emilie]
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1882
Subjects: Porträtfotografie
Stehlin, Hans Georg1870-1941
Ryhiner-Stehlin, Emilie1866-1934

description: Unbekannte/r Fotograf/in
description: Name der abgelichteten Personen gemäss handschriftlicher Notiz auf der Rückseite der Kabinettkarte
description: Abzug auf eine Kabinettkarte montiert
Which environmental conditions and core precipitation characteristics led to the rapid intensification of Hurricane Earl (2010)?
Creators: name: Susca-Lopata, Gabriel Anthony
Publisher: name: University of Utah
Year: 2014

description: Global analysis fields, infrared and passive microwave satellite observations, lightning data, and airborne radar reflectivity and dual-Doppler wind analyses show the evolution of environmental conditions, precipitation characteristics, and kinematic structure before, during, and after the rapid intensification (RI) of Hurricane Earl (2010). The relationship between the RI and environmental conditions, intense inner-core convection, inner-core precipitation coverage, core cold-cloud precipitation symmetry, and the radial distribution of convection is examined. The onset of RI occurs despite moderate vertical wind shear. An episode of intense convection occurs before the RI onset, but an examination of the mesoscale and convective-scale kinematic processes during this convective ‘burst' suggests that the strength of convection alone did not cause the onset of RI. Instead, the dual-Doppler, lightning, and microwave data suggest that the precipitation characteristic that ultimately led to the onset of RI was an increasing trend in cold-cloud precipitation symmetry following the migration of inner-core convection into the northeastern and northern quadrants of the storm within a few hours before RI onset. The evolution of precipitation during the RI suggests that the most important inner-core precipitation characteristics supporting RI are the cold-cloud precipitation symmetry and the predominance of strong convective updrafts within (instead of outside of) the radius of maximum wind (RMW). The wind and precipitation data from Earl indicate that the RMW at multiple levels must be examined. When the RMW is substantially slanted, only considering the low-level RMW can lead to the false conclusion that the strongest convection is located outside of the RMW.
The effect of mystery, mediated by fascination, on recognition memory among college students viewing scenes of nature
Creators: name: Szolosi, Andrew Martin
Publisher: name: University of Utah
Year: 2012
Subjects: Attention restoration theory
Directed attention fatigue
Fascination
Mystery

description: Today?s college students face a number of new and demanding situations that often leave them feeling mentally fatigued. Recovery from this type of fatigue is contingent upon a person being able to rest directed attention, a capacity that requires effort. One approach to resting directed attention is to interact with settings that minimize the demands on that capacity. A natural setting that a person perceives as fascinating could be a critical resource in resting attention as these types of settings presumably evoke a form of attention that is undemanding or effortless. With the prospect of acquiring new information, settings that contain patterns of mystery may offer a means by which to elicit a person?s fascination.  Using a 2 x 4 within-subjects experimental design, participants took part in a recognition memory task (RMT) that examined the effect that scene type and presentation duration had on a student?s capacity to direct attention. The use of presentation duration as an independent variable helped to determine whether or not the processing of certain images was more automatic (effortless) or controlled (effortful). Data garnered from the RMT revealed a significant interaction effect, F(3, 288) = 5.34, p < .05. A closer examination of participants? recognition memory performance within in each duration indicated that when given more time to study an image (5 seconds and 10 seconds), images perceived high in mystery offered the greatest advantages with regard to recognition performance.    Test for mediation provided a means by which to examine the role measured fascination played in mediating the effects between scene type and recognition performance. The results indicated that fascination was an effective mediator both at the 5 sec (B = .205, p < .001) and 10 sec (B = .215, p < .01) durations. The findings from the study not only affirmed the importance of fascination as a mediating variable, but also demonstrated that perceptions of fascination evoked a form of attention that involved both top-down (effortful) and bottom-up (effortless) processing. That experience of fascination as attentional resonance, although not completely effortless, may in fact, more appropriately characterize the quality of rest that is so central to Attention Restoration Theory.
Development of 2-oxindolin-3-ylidene-indole-3-carbohydrazide derivatives as novel apoptotic and anti-proliferative agents towards colorectal cancer cells
Creators: name: Eldehna, Wagdy M.
name: Abo-Ashour, Mahmoud F.
name: Al-Warhi, Tarfah
name: Al-Rashood, Sara T.
name: Alharbi, Amal
name: Ayyad, Rezk R.
name: Al-Khayal, Khayal
name: Abdulla, Maha
name: Abdel-Aziz, Hatem A.
name: Ahmad, Rehan
name: El-Haggar, Radwan
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Mitochondrial anti-apoptotic Bcl2 and BclxL proteins, are overexpressed in multiple tumour types, and has been involved in the progression and survival of malignant cells. Therefore, inhibition of such proteins has become a validated and attractive target for anticancer drug discovery. In this manner, the present studies developed a series of novel isatin–indole conjugates (7a-j and 9a-e) as potential anticancer Bcl2 and BclxL inhibitors. The progression of the two examined colorectal cancer cell lines was significantly inhibited by all of the prepared compounds with IC50 ranges 132–611 nM compared to IC50 = 4.6 µM for 5FU, against HT-29 and IC50 ranges 37–468 nM compared to IC50 = 1.5 µM for 5FU, against SW-620. Thereafter, compounds 7c and 7g were selected for further investigations. Interestingly, both compounds exhibited selective cytotoxicity against both cell lines with high safety to normal fibroblast (HFF-1). In addition, both compounds 7c and 7g induced apoptosis and inhibited Bcl2 and BclxL expression in a dose-dependent manner. Collectively, the high potency and selective cytotoxicity suggested that conjugates 7c and 7g could be a starting point for further optimisation to develop novel pro-apoptotic and antitumor agents towards colon cancer.
Cyclocephala liomorpha Arrow 1911
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala liomorpha

description: Cyclocephala liomorpha Arrow, 1911
Cyclocephala liomorpha Arrow 1911b: 174 (Brazil)
Distribution. Guyana: Dechambre 1979c: 164; Endrödi 1985a: 91, 126; Moore et al. 2018b: 197. “Guianas”: Endrödi 1966a: 236. Brazil: Arrow 1911b: 174, 1937b: 12; Blackwelder 1944: 252; Endrödi 1966a: 236, 1985a: 91, 126; Dechambre 1979c: 164; Moore et al. 2018b: 197. Other: Moore et al. 2018b: 197 (Peru).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 172, DOI: 10.5281/zenodo.3678492
[Porträt der Geschwister Rudolf und Helene Goenner]
Creators: name: Höflinger, August
Publisher: name: [s.n.]
Year: 1895
Subjects: Porträtfotografie
Gönner, Rudolf1889-1918

description: August Höflinger
description: Namen der abgelichteten Personen gemäss handschriftlicher Notiz auf der Rückseite der Kabinettkarte
description: Abzug auf eine Kabinettkarte montiert
Description of suspected adrenal insufficiency in the premature infant
Creators: name: Stevenett, Kathryn
Publisher: name: University of Utah
Year: 2012
Subjects: Innervaton
Adrenocorticotropic Hormone
Hydrocortisone

description: The purpose of this study is to describe the signs and symptoms of suspected adrenal insufficiency in the extremely premature infant.  Fifteen extremely premature infants (EPI) tested with adrenocorticotropic hormone (ACTH) and treated with hydrocortisone (HCTC) were reviewed to describe physiological differences prior to and post treatment with HCTC. Demographic variables were similar among infants.  Baseline serum cortisol levels were less than reported normative values in 7 of 15 infants and response to ACTH was noted as adequate in 5 out of 15 infants. Statistically significant differences in pre and post serum potassium levels could not be supported due to outlying variables. A total of 7 infants had oliguria at the time of diagnosis; 3 resolved post ACTH testing and 4 resolved post HCTC. The latter 4 infants had a significant increase in urine output only after HCTC and despite previous hours of dopamine treatment. Systolic blood pressures (SBP's) rose significantly post HCTC. Mean Air-way pressure (MAP) and percent of inspired oxygen (Fio2) showed a significant improvement in all 15 infants, including 3 who were extubated and on nasal canula by 8 days post HCTC.  The findings of this retrospective study are purely descriptive and in no way meant to promote the use of steroids among extremely premature infants.  The description of findings may, however, promote future research as to the potential of adrenal insufficiency in this population.
Sociophonetic study of (AI) in Utah English
Creators: name: Sykes, Robert D
Publisher: name: University of Utah
Year: 2012
Subjects: Sociophonetics
Utah English
SocioLinguistics

description: This thesis is a variationist study of a reputed "Third Dialect" of American English; - the variety of English; spoken in the Salt Lake Valley. Wendy Morkel's  dialectological study revealed that the Southern monophthongal (ai) is present in Utah. Morkel's study follows the study of Di Paolo and Faber predicting the  Southern Rotation in Utah. This thesis is a sociophonetic assessment of these claims. Sociolinguistic interviews of seven young adults in Utah were analyzed acoustically. Results of the acoustic analysis indicated that glide-weakening in (ai) is present in Utah English; and is conditioned by the voicing of the following consonant, consistent with Southern patterns. Glides tend to be weaker before voiced obstruents, nasals, and in open syllables. However, this thesis found that the front-upgliding word classes are inconsistent with Southern patterns. The analysis also revealed that gender plays an important role, with men weakening glides significantly more than women. This thesis frames the results of the analysis within sociolinguistic theory and will show how the evidence presented can inform  sociolinguistic research both linguistically and socially.
Chromatin remodeling involves ATP-dependent DNA translocation
Creators: name: Saha, Anjanabha
Publisher: name: University of Utah
Year: 2012
Subjects: Genetis
Metabolism
Adensoine Triphosphate

description: The eukaryotic genome is packaged into conserved protein-DNA structures called chromatin, which play crucial roles in various cellular processes like transcription, replication, repair and recombination.  The basic repeating unit of chromatin is a nucleosome, which consists of 146 bp of DNA wrapped around a cylindrical histone octamer.  Nucleosomes repress transcription by blocking the access of various factors to nucleosomal DNA.  However, there are chromatin remodeling complexes (remodelers) the couple ATP hydrolysis to mobilize nucleosomes to increase factor access to nucleosomal DNA.  We have utilized RSC (remodels the structure of chromatin), an essential and abundant remodeler for S. cerevisiae to study the mechanistic basis of chromatin remodeling.  Using triple-helix strand displacement activity, and DNA length-dependent ATPase activity we established that RSC, and its isolated ATPase subunit Sth1, are DNA translocases.  We found that a DNA, template, RSC/Sth1 tracked along one strand of the DNA duplex with a 3'?5' translocation polarity and a tracking requirement of one base.  We further investigated how the property of directional ATP-dependent DNA translocation is utilized to access nucleosomal DNA.  RSC, as well as the translocase domain of Sth1, bind to the nucleosome resulting in the generation of hypersensitive sites about two turns from either side of the nucleosomal dyad.  Using nucleosome substrates bearing the different linker lengths, or bearing gaps of nicks in the DNA, we found that  the restriction enzyme accessibility of the nucleosomal DNA involved RSC drawing DNA from one side of the nucleosome and pumping it out of the octamer from the other rend, to make the underlying DNA assessable.  Based on these results, we propose that nucleosome mobilization involves directional DNA translocation along the surface of the histone octamer from a fixed internal site about two turns from the nucleosomal dyad.
Cyclocephala literata Burmeister 1847
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala literata

description: Cyclocephala literata Burmeister, 1847
Cyclocephala literata Burmeister 1847: 60 (Brazil - LECTOTYPE)
Distribution. French Guiana: Endrödi 1966a: 236, 1985a: 56, 132; Duranton 2011: 13 (?); Moore et al. 2018b: 197. Brazil: Burmeister 1847: 60; Arrow 1937b: 12; Blackwelder 1944: 252; Endrödi 1966a: 236 (designation LECTOTYPE Cyclocephala literata), 1985a: 56, 132; Moore et al. 2018b: 197. Other: Ponchel 2011 (not mentioned); Dupuis 2016b (not mentioned).
Note. Cyclocephala literata is recorded for French Guiana by Endrödi (1966a: 236, 1985a: 56, 132) and this record is repeated in Moore et al. (2018b: 197). Duranton (2011: 13) notes he saw no definite speci- mens from French Guiana, and the species is not mentioned by Ponchel (2011) and Dupuis (2016b). All other detailed records are from southern Brazil. Because of the lack of any recent records we consider its occurrence in the research area uncertain and in need of confirmation.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 172, DOI: 10.5281/zenodo.3678492
[Porträt von Hans Heussler zusammen mit Emil Sulger]
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1915
Subjects: Porträtfotografie
Heußler, Hans1855-1919
Sulger-Gebing, Emil1863-1923

description: Namen der abgelichteten Personen gemäss handschriftlicher Notiz auf der Rückseite der Aufnahme
description: Unbekannte/r Fotograf/in
Pensamiento médico social colombiano a mediados del siglo XX: Caso Manuel Zapata Olivella
Creators: name: URREGO-MENDOZA, Zulma Consuelo
Publisher: name: Zenodo
Year: 2024

description: Presentación pública con resultados de investigación del proyecto Pensamiento médico social colombiano a mediados del siglo XX: el caso de Manuel Zapata Olivella.
Has s/l Knopp z. fr. Er
Creators: name: Höflinger, Jakob
Publisher: name: [s.n.]
Year: 1882
Subjects: Porträtfotografie
His, Wilhelm1863-1934
Salis, Ludwig R. von1863-1934
Planta, Robert von1864-1937
Burckhardt, Daniel1865-1949

description: Gruppenporträt der Activitas der Paedagogia Basel
description: J. Höfligner
description: Abzug auf einen Karton montiert
description: Titel und Daiterung gemäss handschriftlicher Notiz auf der Rückseite der Unterlage
description: Abgelichtet sind gemäss handschriftlicher Notiz auf der Rückseite der Unterlage: Obere Reihe (von links nach rechts): Karl Fischer, Wilhelm His, Adolf Hägler; mittlere Reihe (von links nach rechts): Hans Rudin, Ludwig Rudolf von Salis, Robert von Planta, Daniel Burckhardt; untere Reihe (von links nach rechts): Hans Albrecht, Wilhelm Burckhardt