cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Exploring biological mechanisms and biomarkers through lipidomics
Creators: name: Timo, Sara
Publisher: name: Università del Piemonte Orientale
Year: 2022
Subjects: subject: Lipidomic; plasma; PBMCs
subject: Lipidomic
subject: PBMCs
subject: plasma

description: In this Ph.D. thesis lipidomic analysis has been adopted to explore alteration in biological mechanisms and biomarkers in three different case-studies: virus infection, environmental condition, and cancer disease. The first study is focused on the alteration of plasma (161 samples) and cells (peripheral blood mononuclear cells lipids) (21 samples) in patients affected by COVID-19. Our data demonstrated that lipids are involved in the host response, particularly the glycerophospholipids class and fatty acids but also in membrane remodeling and prostaglandins production. Notably, some lipid species resulted suitable to be used as possible biomarkers. The results from the analysis of cells, confirmed the role of lipids in the immune response against SARS-CoV-2 infection. The second part of the research focused on the study of the lipidome alteration caused by different types of gravity in vitro and in vivo. The effects of microgravity was evaluated on human pancreatic ductal adenocarcinoma cell line. It was observed that exposure to microgravity for seven days leads to a morphological alteration, towards the acquisition of stemness profile. The effects of hypergravity was evaluated using a murine model. It was found that this stressfull condition brings to a decreased levels of most of the lipid classes identified. The last part of the research study reports an untargeted and targeted UHPLC-HRMS lipidomics analysis on plasma samples belonging to patients affected by prostate cancer and patients affected by chronic prostate inflammation. Both with elevated levels of prostate specific antigen and for this reason both groups of patients were subjected to biopsy. In this thesis it has been shown how lipidomics can be used to better understand the impairment in biological pathways and mechanisms that occur in the host. Furthermore, it was demonstrated that lipids can be used as a powerful diagnostic tool for some pathologies, avoiding unnecessary and invasive treatments.
Stereoselective Synthesis of the Quettamine Skeleton
Creators: name: Dirnberger, D.
name: Wiegrebe, Wolfgang
Publisher: name: Universität Regensburg
Year: 1990
Subjects: subject: 540 Chemie

description: A synthesis of the quettamine skeleton 29 is described comprising ring closure of the diastereomeric phenolic 1-(α-bromobenzyl)-tetrahydroisoquinolines 27a and 27b. In both cases only one diastereomer was obtained. NOE-experiments confirm Shamma's assignments concerning the stereochemistry. - Various attemps to cleave the dithiane derivative 5 of an α-amino ketone in order to obtain the ketone 6 failed on account of the non-bonding electron pair at the N-atom. Wir beschreiben die Synthese des Quettamin-Gerüstes 29 durch Ringschluß der diastereomeren 1-(α-Brombenzyl)-tetrahydroisochinoline 27a and 27b. In beiden Fällen resultierte nur ein Diastereomer. NOE-Messungen bestätigen Shamma's Aussagen zur Stereochemie. - Zahlreiche Versuche, das Dithian-Derivat 5 eines α-Aminoketons zum Keton 6 zu spalten, schlugen fehl wegen des nichtbindenden Elektronenpaars am Stickstoff.
Recensione a: S. Deiana, Un'ermeneutica della formazione umana (2017)
Creators: name: Quercetti, Giulia
Publisher: name: Università degli Studi di Cagliari
Year: 2019

description: Il proposito che sin dal titolo Un’ermeneutica della formazione umana. Il pensiero di Hans Georg Gadamer come discorso pedagogico si presenta come linea guida di questo lavoro di Salvatore Deiana è quello di attraversare la ricca e composita produzione gadameriana evidenziandone la portata pedagogica che, seppur spesso implicita, costituisce l’orizzonte fondamentale di un pensiero che si presenta come indissociabile dalla pratica...
description: Critical Hermeneutics, Vol 2, No 2 (2018): Reciprocity as an Ethical-Political Principle: In Memory of Domenico Jervolino (1946-2018)
ASSESSMENT OF HUMAN RESOURCE MANAGEMENT PRACTICES IN ETHIOPIAN CONSTRUCTION WORKS CORPORATION
Creators: name: SAMUEL ALEMU
Publisher: name: Zenodo
Year: 2017

description: The purpose of this research was to assess the human resource management practices in

Ethiopian Construction Works Corporation. Data was gathered from employees of head office.

Descriptive analysis method was used to analyze the data and both qualitative and quantitative

approaches were employed. Primary data was collected using five Point Likert-Scale

questionnaires; 80 responses were properly filled and returned. After the required data are

collected descriptive (i.e. frequency, percentage and mean) analysis were used to analyze the

data using SPSS version 20. The findings indicated that there was no proper planning for the

recruitment and selection process, Majority of the employees was not treated fairly by the

recruitment panels, the recruitment process focuses more internally, the employees were not

satisfied by the benefit packages of the Corporation as compared to most other organizations

offer. The Corporation should adjust the benefit packages so that it can retain employees who

are dissatisfied by the benefit packages of the corporation.
Left atrial conduit function: a Janus two-faced diastolic, powerful parameter
Creators: name: Zanaboni, Jacopo
Publisher: name: Università del Piemonte Orientale
Year: 2022
Subjects: subject: Left atrial conduit funtion; heart failure; pulmonary circulation; functional capacity
subject: Left atrial conduit funtion
subject: heart failure
subject: pulmonary circulation
subject: functional capacity

description: Heart failure (HF) is a frequent clinical condition in which the heart cannot guarantee an adequate cardiac output, or it can do that at the cost of increasing intra-cardiac pressures, causing symptoms, reduced quality of life and poor prognosis. Left atrial (LA) function has an underappreciated role in HF pathophysiology. Aim: to assess if a larger LA conduit contribution to the left ventricular (LV) filling was associated with a heavier pulmonary haemodynamic burden, and, consequently, with a reduced patients’ functional capacity and worse survival. Methods: 60 HF patients (67 ± 11 years, ejection fraction 39 ± 11%, range 20-62%) underwent 6 minute walk test (6MWT) and 3D transthoracic echocardiography. LA conduit was computed off-line,gathering simultaneous real-time 3D multibeats (six cycles)LA and LV volume curves, with conduit (time) = [LV volume(time) - LV minimum volume] - [LA maximum volume - LA volume(time)], and expressed as % LV stroke volume. Atrial stiffness (Kla) was computed using noninvasively assessed wedge pressure divided by LA reservoir (maximum - minimum) volume. Pulmonary arterial compliance (PAC), representing the pulsatile component of right ventricular (RV) afterload wasobtained as the ratio between RV stroke volume and noninvasively estimated pulmonary pulse pressure. Results: Conduit averaged 34±12%, PAC 3.1±1.1 ml/mmHg, 6MWT 404±154 m. Conduit was independent of LV volumes and ejection fraction, showing a direct dependence on noninvasive Kla (r=0.56; P <0.001). Dividing patients into tertiles according to 6MWT and to PAC, the largest conduit fraction was associated with the lowest functional capacity (P<0.001) and most deranged PAC (P<0.001), respectively, suggesting outmost RV haemodynamic burden. Tertiles of conduit predicted survival (P=0.01). Conclusion: conduit depends on Kla and appears to be increased in heart failure patients with lowest capacity and worst survival, likely as RV pulsatile afterload, as reflected by PAC, is highest in these individuals.
A Game Theoretic Foundation for the Stiglitz-Weiss Model
Creators: name: Arnold, Lutz G.
Publisher: name: Universität Regensburg
Year: 2007
Subjects: subject: Key words: credit rationing, redlining, asymmetric information.
subject: 330 Wirtschaft

description: Contrary to what is usually assumed in the literature, the return function (i.e., the relation between the interest rate on loans and the resulting rate of return) cannot be globally humpshaped in the Stiglitz-Weiss (1981) adverse selection model with a continuum of borrower types. It is possibly non-monotonic, but it attains its global maximum at the maximum interest rate beyond which there is no demand for capital. Arnold and Riley (2007) argue that if the return function has a unique local maximum and there is excess demand at the corresponding interest rate, the two-interest rate equilibrium discussed by Stiglitz and Weiss (1981) in the context of a return function with multiple humps is the natural equilibrium outcome of the model. The present paper substantiates this claim by providing an explicit game theoretic foundation for the Stiglitz-Weiss (1981) model. Modeling competition in the markets for deposits and credit as a two-stage game, as in Stahl (1988) and Yanelle (1989), we show that the two-interest rate allocation occurs in any subgame perfect pure-strategy equilibrium if the credit subgame precedes the deposit subgame.
The mixed Yamabe problem for harmonic foliations
Creators: name: Rovenski, Vladimir
name: Zelenko, Leonid
Publisher: name: arXiv
Year: 2014
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics

description: The mixed scalar curvature of a foliated Riemannian manifold, i.e., an averaged mixed sectional curvature, has been considered by several geometers. We explore the Yamabe type problem: to prescribe the constant mixed scalar curvature for a foliation by a conformal change of the metric in normal directions only. For a harmonic foliation, we derive the leafwise elliptic equation and explore the corresponding nonlinear heat type equation. We assume that the leaves are compact submanifolds and the manifold is fibered instead of being foliated, and use spectral parameters of certain Schrödinger operator to find solution, which is attractor of the equation.
description: 24 pages, 6 figures
Indice / Index, v. 2 n. 2
Creators: name: H, C
Publisher: name: Università degli Studi di Cagliari
Year: 2019

description: Documento contenente l'indice del v. 2. n. 2 (December 2018) di Critical Hermeneutics
description: Critical Hermeneutics, Vol 2, No 2 (2018): Reciprocity as an Ethical-Political Principle: In Memory of Domenico Jervolino (1946-2018)
Dal testo all’azione, al corpo: corporeità e percezione tra semiotica e filosofia del linguaggio
Creators: name: Altieri, Lorenzo
Publisher: name: Università degli Studi di Cagliari
Year: 2019

description: These reflections arise from a double teaching: First from those of Ricoeur, and then those of Jervolino. Particularly strong in their interpretation of hermeneutics, and we may say the philosophical practice as a whole, is the urgency of reality – that is, the need to have interpretation, language and praxis converge. From Text to Action and The Words of Praxis are two of the titles that inspire the following thoughts. They indicate a bearing, a direction in which to search. The basic idea is to go "beyond the text", to understand semiotics and hermeneutics as activities rooted in bodily and experiential practice. The impression is that the relationship between classic semiotics and perception is one of disinterest in the best of cases, and in the worst of ill-concealed annoyance. Having developed as a logical-linguistic theory on the one hand, or as a logic of cultures on the other, traditional semiotics did not deal with the subject of perception and experience in a fruitful way, lingering for a long time on a structuralism-based textualism. From this point of view, the meeting between semiotics and phenomenology – which, even before Merleau-Ponty, makes perception the main object of its investigation, and indeed the very field of its own development – has long been deferred. Our attempt to bring semiotics, phenomenology and the philosophy of language together, in a common space to be drawn, leads us to reflect on the way in which the question of perception has been (or not been) approached at the crossroads of these disciplines. Ours obviously will not be a historiographical reread, but rather a critical one, looking to identify some theoretical nodes that allow us to explore the issues that enliven this reflection. As Ricœur would say, we must move “from text to action”.
description: Critical Hermeneutics, Vol 2, No 2 (2018): Reciprocity as an Ethical-Political Principle: In Memory of Domenico Jervolino (1946-2018)
C-12-Substituted Indolo [2,1-a]isoquinolines as Estrogen Receptor Affinic Cytostatic Agents
Creators: name: Ambros, R.
name: Angerer, S. von
name: Wiegrebe, Wolfgang
Publisher: name: Universität Regensburg
Year: 1988
Subjects: subject: 540 Chemie

description: Methoxysubstituted 5,6-dihydro-indolo[2,1-a]isoquinolines with a methyl (2b-f) or a formyl group at C-12 (4a-f) and 12,12-dimethylisoquinolinium salts (3b-f) were synthesized and tested for cytostatic activity in vitro. The tetramethoxy-indoloisoquinoline 4f was the most active derivative in the P 388 D1 leukemia cell line, whereas compounds with two methoxy groups (4a, 4b) were more potent against the MDA-MB 231 mammary tumor cells. The tetraacetoxy-12-formyl-5,6-dihydro-indoloisoquinoline 9 has proven to be active in both cell lines (T/C = 5 %). In vivo it increased the life span of mice with P 388 leukemia (T/C = 133 %). The acetates 7 and 8 exhibited binding affinities for the estrogen receptor, but did not exert a selective action on hormone-dependent MCF-7 cells. Methoxysubstituierte 5,6-Dihydro-indolo[2,1-a]isochinoline mit einer Methyl- (2b-f) oder Formylgruppe an C-12 (4a-f), sowie die 12,12-Dimethylisochinoliniumsalze 3b-f wurden synthetisiert und auf cytostatische Wirksamkeit in vitro getestet. Das Tetramethoxyindoloisochinolin 4f war die aktivste Substanz an P 388 D1-Leukaemiezellen, während Verbindungen mit zwei Methoxygruppen (4a, 4b) an der menschlichen MDA-MB 231-Zellinie wirksamer waren. Das Tetraacetoxy-12-formyl-5,6-dihydroindoloisochinolin 9 war an beiden Zellinien aktiv (T/C = 5 %). In vitro verlängerte 9 die Überlebenszeit von Mäusen mit P 388-Leukaemie (T/C = 133 %). Die Acetate 7 und 8 zeigten Affinität zum Östrogenrezeptor, aber bewirkten keine selektive Hemmung an hormonabhängigen MCF-7 Zellen.
10-(ω-Carboxylacyl)-dithranol-Derivatives
Creators: name: Tanzer, H.
name: Seidel, M.
name: Wiegrebe, Wolfgang
Publisher: name: Universität Regensburg
Year: 1989
Subjects: subject: 540 Chemie

description: The title compounds are not available by hydrolysis of the pertinent esters on a preparative scale. Therefore, they were prepared by base catalyzed condensation of dicarboxylic acid dichlorides or succinic acid monobenzylesterchloride, respectively, with dithranol (1). Their ICso-values for glucose-6- phosphate dehydrogenase are lower than that of dithranol (1), whilst 10- ethyldithranol (6) and the o-(ω-carboxyalkyl)-derivatives 8 and 9 are weaker inhibitors. Die Titelverbindungen sind nicht aus den entspr. Estern präparativ zugänglich, sondern wurden aus Dicarbonsäuredichloriden bzw. Bernsteinsäuremonobenzylesterchlorid und Dithranol (1) hergestellt Die ICso-Werte dieser Substanzen für Glucose-6-phosphat-Dehydrogenase sind kleiner als der von Dithranol (1), 10-Ethyldithranol (6) und die o-(ω-Carboxyalkyl)-Derivate 8 und 9 sind dagegen schwächere Inhibitoren.
Experimental Clocking of Nanomagnets with Strain for Ultra Low Power Boolean Logic
Creators: name: D'Souza, Noel
name: Fashami, Mohammad Salehi
name: Bandyopadhyay, Supriyo
name: Atulasimha, Jayasimha
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Nanomagnetic implementations of Boolean logic [1,2] have garnered attention because of their non-volatility and the potential for unprecedented energy-efficiency. Unfortunately, the large dissipative losses that take place when nanomagnets are switched with a magnetic field [3], or spin-transfer-torque [4] inhibit the promised energy-efficiency. Recently, there have been experimental reports of utilizing the Spin Hall effect for switching magnets [5-7], and theoretical proposals for strain induced switching of single-domain magnetostrictive nanomagnets [8-12], that might reduce the dissipative losses significantly. Here, we demonstrate, for the first time, that strain-induced switching of single-domain magnetostrictive nanomagnets of lateral dimensions ~200 nm fabricated on a piezoelectric substrate can implement a nanomagnetic Boolean NOT gate and unidirectional bit information propagation in dipole-coupled nanomagnets chains. This portends ultra-low-energy logic processors and mobile electronics that may be able to operate solely by harvesting energy from the environment without ever requiring a battery.
description: New version
Android App zur Unterstützung des Memorierens mithilfe der Loci Methode
Creators: name: Diebels, Matthias Alexander
Publisher: name: RWTH Aachen University
Year: 2018
Subjects: subject: 004

description: Bachelorarbeit, RWTH Aachen, 2018; Bachelorarbeit, RWTH Aachen, 2018
Automatischer Aufbau von Hypertext-Basen aus deskriptiv expositorischen Texten: Ein Hypertext-Modell für das Information-Retrieval
Creators: name: Hammwöhner, Rainer
Publisher: name: Universität Regensburg
Year: 1990
Subjects: subject: 020 Bibliotheks- und Informationswissenschaft

description: Mikrofiche-Ausgabe
La traduzione come momento di pace. La sfida felice  di Domenico Jervolino
Creators: name: Canullo, Carla
Publisher: name: Università degli Studi di Cagliari
Year: 2019

description: Speaking about translation without mentioning the work of Domenico Jervolino is unjust and meaningless. Unjust because Jervolino was the author who in Italy had strongly promoted a "philosophy of translation" as Philosophical Hermeneutics and not only as branch of Analytic Philosophy. Meaningless because if we ignore Jervolino’s work, we would squander one of the clearest explanations of the implications of translation, namely its political role. Thanks to Jervolino we can meditate on this task and also understand the possible developments of translation, which helps to promote and increase peace.
description: Critical Hermeneutics, Vol 2, No 2 (2018): Reciprocity as an Ethical-Political Principle: In Memory of Domenico Jervolino (1946-2018)
Single nucleotide polymorphisms imputed to the Multimorbid3D algorithm
Creators: name: Salie, Mariam
Publisher: name: figshare
Year: 2022
Subjects: Biological network analysis
Gene expression (incl. microarray and other genome-wide approaches)

description: These are single nucleotide polymorphisms that are associated with late-onset Alzheimer's in the GWAS Catalog that were pulled and run through the Multimorbid3D algorithm.
Il diritto all'oblio del condannato penale
Creators: name: Gimigliano, Silvia
Publisher: name: Università del Piemonte Orientale
Year: 2022
Subjects: subject: Diritto all'oblio; condannato penale; bilanciamento; libertà di informazione; memoria; cause estintive; principio rieducativo
subject: Diritto all'oblio
subject: condannato penale
subject: bilanciamento
subject: libertà di informazione
subject: memoria
subject: cause estintive
subject: principio rieducativo

description: Lo scritto, articolato in quattro capitoli, si propone di analizzare il diritto all'oblio in rapporto alla figura del condannato penale. Quando ne è titolare quest'ultimo, tale diritto pone, infatti, temi e problemi peculiari, meritevoli di autonoma disamina. Il primo capitolo, di taglio introduttivo, è finalizzato all'individuazione delle direttrici di ricerca: la ricognizione di contenuti e caratteristiche generali della posizione soggettiva consente di cogliere, in controluce, le specificità che caratterizzano il diritto all'oblio (del reato e) della condanna, oggetto di approfondimento nei capitoli successivi. Segnatamente, il secondo capitolo è dedicato al conflitto con altre situazioni giuridiche, con particolare riguardo al tema del bilanciamento normativo e giurisprudenziale, mentre il terzo ha ad oggetto il rapporto con principi ed istituti penali, fra i quali spiccano il principio rieducativo sancito dall'art. 27, co.3, Cost. e le cause estintive della pena. Nel quarto capitolo si formulano, infine, conclusioni motivate, mettendo in evidenza, per un verso, la natura fragile - eppure non debole --- della declinazione in esame, e, per altro verso, l'insufficienza delle definizioni "classiche" di oblio con riferimento alla figura del condannato
Dal soggetto alla traduzione: il contributo di Domenico Jervolino per una ermeneutica psicoanalitica
Creators: name: Martini, Giuseppe
Publisher: name: Università degli Studi di Cagliari
Year: 2019

description: The author examines the most significant texts of Domenico Jervolino, that present references to psychoanalysis, identifying the leitmotif of his work in the passage from the subject matter to the philosophy of translation. If this happens following Ricoeur's thought, however, it is the work of the Neapolitan philosopher to privilege this line of thought, to enrich it with his personal contributions and to emphasize the ethical dimension. Also Domenico Jervolino's most important contribution for a psychoanalytic hermeneutics can be identified in the relationship between subject and translation: a) in the enhancement of a problematic subject, which is constantly in question and is conditioned by alterity, which is in him and outside of him; b) in the emphasis of translation intended as a transformative work of the subject itself and perceived in constant relation with the "hidden face of Language"; and finally c) in the call to the ethics of hospitality, which can also be understood as a fundamental engine of the analytical encounter.
description: Critical Hermeneutics, Vol 2, No 2 (2018): Reciprocity as an Ethical-Political Principle: In Memory of Domenico Jervolino (1946-2018)
WP3: Atlas of representative cases of XUV-irradiated exoplanetary atmospheres.
Creators: name: Locci, Daniele
name: Maggio, Antonio
name: Cecchi Pestellini, Cesare
name: Micela, Giuseppina
name: Bonomo, Aldo Stefano
Publisher: name: Zenodo
Year: 2023
Subjects: gaseous planets
planetary atmospheres
star-planet interactions
Photochemistry
High-Energy Irradiation

description: In this repository we gather preliminary results of atmospheric photo-chemistry modeling for a representative sample of exoplanets, taking into account the high-energy irradiation from the host stars. The sample is composed of five planetary systems, for which trasmission spectroscopy with GIANO-B@TNG was performed in the framework of a Long-Term observation program (PI G. Micela) carried on by the Global Architecture of Planetary Systems (GAPS) collaboration. These systems are also included in the Reference Sample of the Ariel mission.
Metabolic Requirements of Blood Vessels in a Perfusion Bioreactor
Creators: name: Hoenicka, Markus
name: Wiedemann, Ludwig
name: Schrammel, Siegfried
name: Schmid, Christof
name: Birnbaum, Dietrich E.
Publisher: name: Universität Regensburg
Year: 2009
Subjects: subject: 570 Biowissenschaften, Biologie
subject: 610 Medizin

description: Small caliber vessel grafts are one of the major challenges of vascular tissue engineering. A variety of processes have been developed to create vascular grafts from scaffolds and donor cells in bioreactors. In order to optimize such processes, this study focused on monitoring vessel metabolism under conditions typically used in perfusion protocols. Bovine veins were perfused in a bioreactor for four days. Group 1 vessels served as controls and were perfused with standard medium. Medium of group 2 was adjusted to the viscosity of blood. Group 3 vessels were additionally challenged with elevated luminal pressure. Contractile function was assessed in an organ bath. Tissue viability was determined by tetrazolium dye reduction. Oxygen gradients, dextrose consumption, and lactate production were monitored using a blood gas analyzer. KCl induced contractions did not differ between days 0 and 4. Norepinephrine dose-response curves of group 3 vessels achieved a higher maximum contraction on day 4, with no changes of EC50. Tissue viability was not altered by any of the perfusion conditions. Oxygen gradients across the vessels did not change with time but were elevated in group 2, with no signs of oxygen depletion. Dextrose consumption and lactate formation of group 1 and 2 vessels appeared to be stoichiometric. In contrast, group 3 vessels produced more lactate than dextrose could supply. These results indicate that conventional oxygenation of culture media is sufficient to meet the oxygen consumption of a functional vessel. Elevated shear forces increased the oxygen demand without affecting dextrose consumption. Elevated shear forces and luminal pressure caused the utilization of alternative energy sources. Thus online monitoring of key metabolic parameters appears to be a desirable feature of perfusion bioreactors for vascular tissue engineering.
La dislocazione a sinistra nel greco classico: Sofocle a confronto con la prosa e la poesia attica del V-IV secolo A.C.
Creators: name: Loberti, Martina
Publisher: name: Università del Piemonte Orientale
Year: 2022
Subjects: subject: Dislocazione a sinistra; greco antico; linguistica; tragedia; commedia; prosa; teatro
subject: Dislocazione a sinistra
subject: greco antico
subject: linguistica
subject: tragedia
subject: commedia
subject: prosa
subject: teatro

description: La tesi ha come obiettivo quello di analizzare, dal punto di vista pragmatico, la struttura linguistica della dislocazione a sinistra nel greco antico. Nella prima parte vengono indicati alcuni criteri utili per l’individuazione degli elementi dislocati; si passa poi all’analisi vera e propria del corpus di riferimento (ovvero i trimetri presenti nelle tragedie di Sofocle, i trimetri delle Nuvole e degli Uccelli di Aristofane e il primo libro dell’Anabasi di Senofonte). In seguito, la trattazione verte sulla posposizione dell’elemento interrogativo nelle commedie di Aristofane e sulla tipologia di domande in corrispondenza delle quali è possibile riscontrare questo fenomeno. Nelle ultime due sezioni si passa all’analisi diacronica della dislocazione a sinistra; dapprima ci si focalizza sulla tragedia, prendendo in esame I Sette Contro Tebe di Euripide e l’Ecuba di Euripide al fine di poter confrontare le tipologie di dislocazioni qui riscontrate con quelle di Sofocle. In seguito, si procede con l’analisi del Dyskolos di Menandro e dell’Areopagitico di Isocrate per poter paragonare anche i risultati ottenuti dallo studio riguardante la commedia e la prosa. Infine, all’interno dell’ultimo capitolo, vengono presentate le conclusioni generali della presente tesi.
title: Gesundheitliche Bewertung von Nikotinbeuteln (Nikotinpouches): Aktualisierte Stellungnahme Nr. 023/2022 des BfR vom 7. Oktober 2022
Creators: name: Bundesinstitut Für Risikobewertung
Publisher: name: Bundesbehörden und Einrichtungen im Geschäftsbereich des Bundesministeriums für Ernährung und Landwirtschaft (BMEL)
Year: 2022
Subjects: subject: 000

description: BfR-Stellungnahmen, vol. 2022, no. 023
Managing large-scale scientific hypotheses as uncertain and probabilistic data with support for predictive analytics
Creators: name: Gonçalves, Bernardo
name: Porto, Fabio
Publisher: name: arXiv
Year: 2014
Subjects: subject: Databases (cs.DB)
subject: FOS: Computer and information sciences
subject: H.2.1

description: The sheer scale of high-resolution raw data generated by simulation has motivated non-conventional approaches for data exploration referred as `immersive' and `in situ' query processing of the raw simulation data. Another step towards supporting scientific progress is to enable data-driven hypothesis management and predictive analytics out of simulation results. We present a synthesis method and tool for encoding and managing competing hypotheses as uncertain data in a probabilistic database that can be conditioned in the presence of observations.
description: 16 pages, 9 figures, 1 table
Credit statement for the Force2019 Architecting Attribution poster
Creators: name: Holmes, Kristi
name: McMurray, Julie
Publisher: name: Galter Health Science Library & Learning Center
Year: 2019

description: The Architecting Attribution poster was presented at the 2019 Force11 conference. It was inspired by the Hasbro game Candyland, seen reflected in the design choices and presentation of content. The image used to highlight an example of an interdisciplinary team and the contributions they make to a project was designed by Julie McMurray. The poster uses a number of digital images and clipart in the design, which are noted in the file.
Back of the envelope estimate of the climate impact of the Nord Stream 1 and 2 sabotage
Creators: name: Johannsson, Daniel J.A.
Publisher: name: Zenodo
Year: 2022
Subjects: Methane
Climate impact
Nord Stream
Natural gas

description: The note provides a back of the envelope estimates of the amount of methane leaked from the sabotage of Nord Stream 1 and 2, as well as an estimate of the climate impact of the leaked methane.
Synthesis and Antitumor Activity of Methoxy-indolo[2,1-a]isoquinolines
Creators: name: Ambros, R.
name: Angerer, S. von
name: Wiegrebe, Wolfgang
Publisher: name: Universität Regensburg
Year: 1988
Subjects: subject: 540 Chemie

description: Methoxy-indolo[2,1-a]isoquinolines 8a-f and their dihydroderivatives 7a-f were synthesized by Bischler-Napieralski reaction of the (bromomethoxyphenyl)-[ 2-(methoxyphenyl)-ethyl]acetamides 4a-f, reduction, subsequent cyclization and dehydrogenation. They were tested for cytostatic activity in vitro using P388 D1 leukemia and MDA MB 231 mammary tumor cells. The trimethoxy-5,6-dihydroindoloisoquinoline 7d and the tetramethoxyindoloisoquinoline 8f showed an inhibition of cellproliferation of about 70 % at a concentration of 10-5 molar. Die Methoxy-indolo[2,1-a]isochinoline 8a-f und deren Dihydroderivate 7a-f wurden durch Bischler-Napieralski-Ringschluß der (Brom-methoxyphenyl)- f2-(methoxyphenyl)-ethyl]acetamide 4a-f, Reduktion, Cyclisierung und Dehydrierung gewonnen. Die cytostatische Wirkung wurde in vitro an der P388 D1 und der MDA-MB 231-Zellinie getestet. Das Trimethoxy- 5,6-dihydroindoloisochinolin 7d und das Tetramethoxyindoloisochinolin 8f zeigten eine Hemmung der Zellproliferation von 70 % bei einer Konzentration von 10-5 M.
L’identità normanna: nelle cronache della Normandia e dei paesi dell’espansione normanna tra X e XII secolo
Creators: name: Camellini, Marta
Publisher: name: Università del Piemonte Orientale
Year: 2022
Subjects: subject: identità normanna; storiografia normanna; etnogenesi
subject: identità normanna
subject: storiografia normanna
subject: etnogenesi

description: Questo studio si propone di indagare come il discorso sull'identità normanna si è evoluto tra X e XII secolo in Normandia, Inghilterra e Italia meridionale, attraverso l'uso di fonti letterarie, di tipo storiografico. La prima parte della tesi analizza l'evoluzione dell'identità normanna in quella che ho definito tradizione ufficiale, ovvero quella che si è originata da Dudone da San Quintino e che alla sua versione del passato normanno si è tenuta sostanzialmente fedele. Vi fanno parte: 'Guglielmo di Jumièges, Orderico Vitale, Roberto di Torigni, Wace con il Rou e Benoît de Sainte-Maure. Essa rappresenta la prima e fondamentale etnogenesi del popolo normanno e fu fondata sul principio dell'integrazione al mondo franco e cristiano in stretta connessione con la volontà politica dei duchi. Per portare avanti l'analisi sono stati individuati alcuni temi fondamentali sui quali si è costruito il discorso identitario per poi studiarli trasversalmente agli autori della tradizione ufficiale. In effetti, nonostante una sostanziale fedeltà al progetto elaborato da Dudone, è possibile rintracciare nel corso del tempo dei cambiamenti nella ricostruzione del passato normanno in questi autori. Le variazioni sono preziosi indicatori di un cambiamento nel contesto politico e nella percezione identitaria, che permettono di ricostruire un percorso di evoluzione dell'identità normanna tra X e XII secolo. La seconda parte della tesi, invece, è dedicata alle identità alternative a quella proposta dalla tradizione ufficiale, emerse in Inghilterra e in Italia meridionale. Guglielmo di Malmesbury offre una versione del passato normanno al di là dell'ideologia e più aderente alla realtà. In Inghilterra poi vi fu il tentativo di una nuova fondazione della memoria normanna tramite la proposta di un'ascendenza ideale dei re anglo-normanni ai re bretoni, e in particolare Artù, con Goffredo di Monmouth e il Brut di Wace; tuttavia in seguito si tornò a porre in primo piano l'ascendenza normanna di Enrico II, con il Rou e la Chronique di Benoît. Infine l'Italia meridionale con Amato di Montecassino, Guglielmo il Pugliese e Goffredo Malaterra è lo scenario di un'ultima identità alternativa: per ragioni politiche e sociali legate alla vicenda dei Normanni nel Mezzogiorno, i problemi che avevano attanagliato la memoria e l'identità normanna nel ducato non si presentarono, dando luogo a una nuova fondazione libera dal passato.
An HST/COS Survey of the Low-Redshift IGM. I. Survey, Methodology, & Overall Results
Creators: name: Danforth, Charles W.
name: Keeney, Brian A.
name: Tilton, Evan M.
name: Shull, J. Michael
name: Stevans, Matthew
name: Pieri, Matthew M.
name: Stocke, John T.
name: Savage, Blair D.
name: France, Kevin
name: Syphers, David
name: Smith, Britton D.
name: Green, James C.
name: Froning, Cynthia
name: Penton, Steven V.
name: Osterman, Steven N.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We use high-quality, medium-resolution {\it Hubble Space Telescope}/Cosmic Origins Spectrograph (\HST/COS) observations of 82 UV-bright AGN at redshifts $z_{AGN}<0.85$ to construct the largest survey of the low-redshift intergalactic medium (IGM) to date: 5343 individual extragalactic absorption lines in HI and 25 different metal-ion species grouped into 2610 distinct redshift systems at $z_{abs}<0.75$ covering total redshift pathlengths $Δz_{HI}=21.7$ and $Δz_{OVI}=14.5$. Our semi-automated line-finding and measurement technique renders the catalog as objectively-defined as possible. The cumulative column-density distribution of HI systems can be parametrized $dN(>N)/dz=C_{14}(N/10^{14} cm^{-2})^{-(β-1)}$, with $C_{14}=25\pm1$ and $β=1.65\pm0.02$. This distribution is seen to evolve both in amplitude, $C_{14}\sim(1+z)^{2.0\pm0.1}$, and slope $β(z)=1.73-0.26 z$ for $z<0.47$. We observe metal lines in 427 systems, and find that the fraction of IGM absorbers detected in metals is strongly dependent on N_{HI}. The distribution of OVI absorbers appear to evolve in the same sense as the Lya forest. We calculate contributions to $Ω_b$ from different components of the low-$z$ IGM and determine the Lya decrement as a function of redshift. IGM absorbers are analyzed via a two-point correlation function (TPCF) in velocity space. We find substantial clustering of \HI\ absorbers on scales of $Δv=50-300$ km/s with no significant clustering at $Δv>1000$ km/s. Splitting the sample into strong and weak absorbers, we see that most of the clustering occurs in strong, $N_{HI}>10^{13.5} cm^{-2}$, metal-bearing IGM systems. The full catalog of absorption lines and fully-reduced spectra is available via MAST as a high-level science product at http://archive.stsci.edu/prepds/igm/.
description: This is the accepted version (v3) of the paper. Previous versions (July 2015 and Feb. 2014) should be replaced by this one. In particular, please note that the associated MAST high-level-science product has been updated to reflect the of the final state of the paper. It is available at: http://archive.stsci.edu/prepds/igm/
title: Reden zum Gedächtnis an Frau Dr. Meier-Lahusen Adele geb. Lahusen
title: Feier im Sterbezimmeram Schlossberg-Wädenswil den 27. Januar 1911
titleType: Subtitle
Creators: name: (:Unkn) Unknown
Publisher: name: Hauschild
Year: 1911
Subjects: subject: 920 Biografien, Genealogie, Insignien
subject: Nachruf
subject: Meier, Adele
subject: Wädenswil

description: Enthält: Worte der Erinnerung gesprochen von J. Pfister, Pfarrer; Rede am Sarge in der Kapelle des Waller Friedhofes gehalten am 30. Januar 1911 von Pastor Gustav Volkmann
Polar catastrophe in ultra-thin limit: A case of rare-earth perovskite LaNiO3
Creators: name: Middey, S.
name: Rivero, P.
name: Meyers, D.
name: Kareev, M.
name: Liu, X.
name: Cao, Y.
name: Freeland, J. W.
name: Barraza-Lopez, S.
name: Chakhalian, J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We address the fundamental issue of growth of perovskite ultra-thin films under the condition of a strong polar mismatch at the heterointerface exemplified by the growth of a correlated metal LaNiO$_3$ on the band insulator SrTiO$_3$ along the pseudo cubic [111] direction. While in general the metallic LaNiO$_3$ film can effectively screen this polarity mismatch, we establish that in the ultra-thin limit, films are insulating in nature and require additional chemical and structural reconstruction to compensate for such mismatch. A combination of in-situ reflection high-energy electron diffraction recorded during the growth, X-ray diffraction, and synchrotron based resonant X-ray spectroscopy reveal the formation of a chemical phase La$_2$Ni$_2$O$_5$ (Ni$^{2+}$) for a few unit-cell thick films. First-principles layer-resolved calculations of the potential energy across the nominal LaNiO$_3$/SrTiO$_3$ interface confirm that the oxygen vacancies can efficiently reduce the electric field at the interface.
Tissue Engineering of Small Caliber Vessel Grafts from Human Umbilical Veins
Creators: name: Hoenicka, Markus
name: Schrammel, Siegfried
name: Jacobs, Volker R.
name: Huber, Georgine
name: Schmid, Christof
name: Birnbaum, Dietrich E.
Publisher: name: Universität Regensburg
Year: 2009
Subjects: subject: 570 Biowissenschaften, Biologie
subject: 610 Medizin

description: Human umbilical veins (HUV) have recently been suggested as a starting material for vascular tissue engineering. HUV possess a functional smooth muscle layer and could be turned into an immunologically inert graft with contractile properties by creating a neoendothelium from the recipient's own cells. This study investigated methods to remove the native endothelium without impairing the contractile function of the smooth muscle layer. These denuded HUV were then seeded with endothelial cells in a perfusion bioreactor, demonstrating the creation of a confluent, shear-resistant neoendothelium.
Expressive Experience. An Inquiry Concerning The Expressiveness of Objects
Creators: name: Benenti, Marta
Publisher: name: Università degli Studi di Torino
Year: 2018
Subjects: subject: Expressiveness; expressions; emotions; perception; core affect; aesthetics; phenomenal character; representational content; mental imagery; arousalism; metaphors; secondary meaning
subject: Expressiveness
subject: expressions
subject: emotions
subject: perception
subject: core affect
subject: aesthetics
subject: phenomenal character
subject: representational content
subject: mental imagery
subject: arousalism
subject: metaphors
subject: secondary meaning

description: How is it possible that we hear music or see paintings as expressive of affective states? How is it that this bizarre phenomenon extends to natural landscapes, atmospheres, and also to simple colours, sounds, shapes? This research aims at inquiring the phenomenon of expressiveness. In particular, it focuses on the expressiveness of inanimate objects. What is especially intriguing about expressiveness is that it mobilizes a number of issues concerning the nature of perception and that of affective experiences. Questions about the possibility that affective states such as anxiety, melancholy, sadness, solemnity, liveliness are ascribed to non-sentient beings such as artworks, represent a challenge for theories of perception on the one hand, and for theories of emotions on the other hand. Moreover, most of these questions lay at the crossroads of aesthetics and the philosophy of mind, licking the domains of developmental psychology and cognitive sciences more generally. Main players are analytic philosophers of music and aesthetics that have been dealing with this problem in recent years. Yet, also accounts elaborated within different traditions – like phenomenology and Gestalt psychology – and tracing back in time are analysed.
Probing leptogenesis with GeV-scale sterile neutrinos at LHCb and BELLE II
Creators: name: Canetti, Laurent
name: Drewes, Marco
name: Garbrecht, Björn
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We show that existing laboratory experiments have the potential to unveil the origin of matter by probing leptogenesis in the type-I seesaw model with three right-handed neutrinos and Majorana masses in the GeV range. The baryon asymmetry is generated by CP-violating flavour oscillations during the production of the right-handed neutrinos. In contrast to the case with only two right-handed neutrinos, no degeneracy in the Majorana masses is required. The right-handed neutrinos can be found in meson decays at BELLE II and LHCb.
description: Title changed, discussion extended and references added. 12 pages, one figure
title: Phenomenological reduction and self-recognition
title: An encounter between Merleau-Ponty and Utpaladeva
titleType: Subtitle
Creators: name: Lorandou, Eleni
Publisher: name: Lancaster University
Year: 2023

description: This PhD submission aims at initiating a dialogue between two philosophers, Merleau-Ponty and Utpaladeva, who, within their respective philosophical traditions and through their unique itineraries, offer valuable insights on the constitution and the possibilities of human experience. Through a parallel exploration of the main themes that traverse their philosophies, the reflective thesis attempts to follow the development of the thought that gave rise to the processes of self-recognition and the phenomenological reduction that are central to their systems. This cross-cultural encounter will allow the reader to approach each system from a new angle: look at self-recognition through the experience of the embodied subject and explore the phenomenological reduction through the transcendental dynamics of the self. The joint exploration of the two systems will reveal unexpected relations between them that do not necessarily rely on terminological equivalences but on hermeneutical depth. This will offer the reader the opportunity to rethink the relations of consciousness and matter, body and mind and explore views on the nature of being that challenge all conceptual dichotomies. The aim is to show that both self-recognition and phenomenological reduction are not just theoretical accounts on experience but forms of experience. Understanding the performative value of the two processes will highlight the movement of transcendence that traverses our most ordinary experiences, a movement we tend to ignore despite being inscribed in it by the very fact of our embodiment.
Relative frequencies of supernovae versus properties of spiral hosts
Creators: name: Hakobyan, A. A.
name: Nazaryan, T. A.
name: Adibekyan, V. Zh.
name: Petrosian, A. R.
name: Aramyan, L. S.
name: Kunth, D.
name: Mamon, G. A.
name: de Lapparent, V.
name: Bertin, E.
name: Gomes, J. M.
name: Turatto, M.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: In this work, we present an analysis of SNe number ratios in spiral galaxies with different morphological subtypes, luminosities, sSFR, and metallicities, to provide important information about the physical properties of the progenitor populations.
description: 2 pages, 1 figure
The determinants of market access for medicines: theoretical issues and empirical evidence
Creators: name: Villa, Federico
Publisher: name: Università del Piemonte Orientale
Year: 2021
Subjects: subject: Market Access; HTA,;Pharmaceutical pricing; Regulatory Affairs; Orphan drugs
subject: Market Access
subject: HTA
subject: Pharmaceutical pricing
subject: Regulatory Affairs
subject: Orphan drugs

description: To frame the determinants of drug prices within a complex regulatory system and how these determinants influence the P&R decisions of medicine, an analysis of the Italian reference context as a whole was done, starting from the trends in the use and consumption of drugs, to the analysis of the regulatory process and market access for specific categories of drugs, orphan drugs for rare diseases. Some of the system's shortcomings are the result of limited quality control as a whole over the years, which has led to the adoption of compartmentalized pharmaceutical policies without a medium-long term strategic vision integrating clinical, pharmacoeconomic, and organizational aspects. By critically analyzing the regulatory and access system that regulates the price and reimbursement of drugs, it was possible to: (i) verify the difficult coexistence, in some cases, of European early access strategies with a rapid and complete assessment of HTA at the national level (which frustrate efforts to promote faster drug access pathways); (ii) highlight how the perception of a drug's innovativeness produces different policies in the main regulatory agencies; (iii) to underline the different view of the value of a drug between the company and the payer; (iv) the use of non-standardized P&R criteria for the definition of P&R by AIFA for different products (even for the same therapeutic area); (v) as some classes of drugs, such as orphan drugs, have had a significant increase in terms of products developed thanks to strategies to encourage investment in a previously unprofitable sector, but how this increase has also led to a significant increase in expenditure due to a P&R model not related to the low epidemiology of these diseases and/or the real impact in terms of clinical benefits of these products.
Low-mass fermiophobic charged Higgs phenomenology in two-Higgs-doublet models
Creators: name: Ilisie, Victor
name: Pich, Antonio
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: After the recent discovery of a Higgs-like boson, the possibility of an enlarged scalar sector arises as a natural question. Experimental searches for charged scalars have been already performed with negative results. We analyze the phenomenology associated with a fermiophobic charged Higgs (it does not couple to fermions at tree level), in two-Higgs-doublet models. All present experimental bounds are evaded trivially in this case, and one needs to consider other decay and production channels. We study the associated production of a charged Higgs with either a $W$ or a neutral scalar boson, and the relevant decays for a light fermiophobic charged Higgs. The interesting features of this scenario should result encouraging for the LHC collaborations to perform searches for such a particle.
description: 40 pages, 11 figures. Minor typos corrected