cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 3 of Circular RNA METTL9 contributes to neuroinflammation following traumatic brain injury by complexing with astrocytic SND1
Creators: name: Huang, Chunling
name: Sun, Lulu
name: Xiao, Chenyang
name: You, Wenjun
name: Sun, Li
name: Wang, Siye
name: Zhang, Zhijun
name: Liu, Su
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health

description: Additional file 3: Table S3. The probe sequences of circMETTL9 for RNA pulldown.
sj-pdf-1-jba-10.1177_0885328220972219 - Supplemental material for Biomimetic bone-like composites as osteo-odonto-keratoprosthesis skirt substitutes
Creators: name: Avadhanam, Venkata
name: Ingavle, Ganesh
name: Zheng, Yishan
name: Kumar, Sandeep
name: Liu, Christopher
name: Sandeman, Susan
Publisher: name: SAGE Journals
Year: 2020
Subjects: Materials Engineering not elsewhere classified

description: Supplemental material, sj-pdf-1-jba-10.1177_0885328220972219 for Biomimetic bone-like composites as osteo-odonto-keratoprosthesis skirt substitutes by Venkata Avadhanam, Ganesh Ingavle, Yishan Zheng, Sandeep Kumar, Christopher Liu and Susan Sandeman in Journal of Biomaterials Applications
Add_file_2.rjf_online_supp – Supplemental material for Importance Hierarchy of Surrogate Medical Decision Making Determinants: A Q-Methodology Study in Middle Eastern and East Asian Men
Creators: name: Hammami, Muhammad M.
name: Kafa Abuhdeeb
name: Areej Al Balkhi
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, Add_file_2.rjf_online_supp for Importance Hierarchy of Surrogate Medical Decision Making Determinants: A Q-Methodology Study in Middle Eastern and East Asian Men by Muhammad M. Hammami, Kafa Abuhdeeb and Areej Al Balkhi in Medical Decision Making
Comparative validation of handheld fractional exhaled nitric oxide measurements
Creators: name: van Deelen, Sanne
name: Tramper-Stranders, Gerdien A.
name: Hendriks, Rudi W.
name: Reinders, Marcel J. T.
name: Braunstahl, Gert-Jan
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Hematology

description: Fractional exhaled nitric oxide (FeNO) is a noninvasive method to determine the degree of airway inflammation. Handheld devices such as the Vivatmo Me are used for home monitoring. Differences were found between the Vivatmo Me and standard measurements with the NIOX VERO. Therefore, we aimed to determine the accuracy of the Vivatmo Me for FeNO measurements. Adult patients with an appointment for FeNO-measurement according to regular care, were invited to perform the FeNO measurement with both devices. From these measurements the FeNO values were compared, and the device user-friendliness was determined. One hundred and sixty-four patients were included. The number of attempts needed for a successful measurement and the failure rate were higher with the Vivatmo Me. Although the measurements were highly correlated, a significant difference (p < 0.001) was found between FeNO values measured with both devices. From the Vivatmo measurements, 32% did not fall within the claimed accuracy ranges. A linear correction on the FeNO values reduced this number. Our findings indicate that the Vivatmo Me does not comply with the claimed accuracy of clinical FeNO measurements and the measurement is challenging to perform. By applying the proposed correction, the comparative validity of the FeNO measurement improves and therefore its clinical usefulness.
POLITICAL STABILITY, SECURITY AND SUSTAINABLE DEVELOPMENT IN NIGERIA. A DISOCURSE IN COMPARATIVE ANALYSIS.
Creators: name: Chidi A., Okoroafor, PhD
name: Chidi O., Ukaegbu, PhD
Publisher: name: ZAP JOURNALS
Year: 2025
Subjects: Political Stability, Security, Sustainable Development, Comparative Analysis, Policy Integration

description: Political stability is crucial for creating a secure environment which is indispensable for achieving and maintaining sustainable development in any clime. It ensures a predictable and conducive environment for economic activities and the protection of citizens and resources to enhance uninterrupted progress. The present research work delved into this complex interplay between political stability, security, and sustainable development in Nigeria from a comparative point of view. It adopted specific case study analysis. As such, the study is grounded on a detailed analysis of multiple case studies that provided the basis for comparing Nigeria with other climes. While Political stability ensures a predictable and conducive environment for economic activities, security protects citizens and resources and make them available for uninterrupted progress. Anchored on the theory of sustainable development, popularized by the Brundtland Commission of 1987 which emphasized the balance between economic growth, environmental protection and social equity, and secondary method of data collection, the study asserts that sustainable development is not merely the outcome of economic or environmental efforts but, that which is deeply rooted in the political and security landscape of a region or country. Thus, the need for a comprehensive and integrated policy approach that simultaneously address political stability, security concerns and developmental objectives. By highlighting these interconnections, the study recommended a holistic understanding of and approach to policymaking that aims to ensure that development is not only achieved but also sustained on a long-term basis amidst evolving political and security dynamics in 21st century
Euthanasia – A Step Towards Ensuring the Right to Live a Human Life with Dignity
Creators: HC User
Publisher: name: Humanities Commons
Year: 2023

description: This article aims to address Euthanasia from a humanistic and philosophical standpoint as to why the idea of terming Euthanasia as "Physician-Assisted Suicide" is harmful to the way euthanasia is viewed. More emphasis is laid on the case of Aruna Shanbaug and the Doctrine of Colourable legislation whereby this article puts forth an argument in favour of legalizing Active Euthanasia as a means to end human suffering and a way of ensuring the right to life i.e., to live with dignity and autonomy.  Special emphasis is also being made on the works of Immanuel Kant (nicknamed the Kantian philosophy) along with article 21 of the Indian Constitution.  This article also relies on the Hippocratic corpus to arrive at an inference that death could be a release from suffering and that, in some cases, ending life may be the best option for a patient.  The article also concludes that Euthanasia, be it active or passive, can very much be legalized and aims at giving reasoning for the same. This article also takes into account the logic behind the Doctrine of Colourable Legislation and concludes that a reverse application of the doctrine would very much allow legalizing Euthanasia in all forms.
Upward curvature of the upper critical field in the Boson--Fermion model
Creators: name: Domanski, Tadeusz
name: Maska, Maciej M.
name: Mierzejewski, Marcin
Publisher: name: arXiv
Year: 2002
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We report on a non-conventional temperature behavior of the upper critical field ($H_{c2}(T)$) which is found for the Boson-Fermion (BF) model. We show that the BF model properly reproduces two crucial features of the experimental data obtained for high-$T_c$ superconductors: $H_{c2}(T)$ does not saturate at low temperatures and has an upward curvature. Moreover, the calculated upper critical field fits very well the experimental results. This agreement holds also for overdoped compounds, where a purely bosonic approach is not applicable.
description: 4 pages, 3 figures, revtex
Knockdown of lncRNA-PANDAR suppresses the proliferation, cell cycle and promotes apoptosis in thyroid cancer cells
Creators: name: Li, Zhirong
name: Gao, Bo
name: Hao, Shuai
name: Tian, Wuguo
name: Chen, Yi
name: Wang, Lingli
name: Zhang, Xiaohua
name: Luo, Donglin
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2017
Subjects: thyroid cancer
lncRNAs
PANDAR
proliferation
cell cycle
apoptosis

description: Long non-coding RNAs (lncRNAs) have been found to show important regulatory roles in various human cancers. Lnc-RNA PANDAR is a novel identified lncRNA that was previously reported to show abnormal expression pattern in various cancers. However, little is known of its expression and biological function in thyroid cancer. Here, we used the quantitative real-time PCR (qRT-PCR) to determine the expression of PANDAR in 64 thyroid cancer tissues. We found that expression of PANDAR was up-regulated in thyroid cancer tissues compared with adjacent non-tumor tissues. Functional assays in vitro demonstrated that knockdown of PANDAR could inhibit proliferation, cell cycle progression, induces the apoptosis, inhibit invasion of thyroid cancer cells. Thus, our study provides evidence that PANDAR may function as a potential target for treatment for patients with thyroid cancer.
description: EXCLI Journal; 16:Doc354; ISSN 1611-2156
Prejudice And Heterogeneity: An Overview
Creators: HC User
Publisher: name: Humanities Commons
Year: 2023

description: Conglomerate avow have flatter a unit of worship bias. It is ordinary, if not omnipresent, the invocation for the court belief is “Plaintiff brings his action under Title VII of the Civil Rights Act of 1964 for religious observance and practice.” Enlarged heterogeneity in the prayer’s enumeration suggests that customarily, contrasting treatment may in fact be embedded in interchange or composite bias: although cliché for “women” have somewhat evaporated. Composite bias dispenses a jetton description to the present depiction of prayers prejudice as fine or insentient. In spite of the ordinary sight conception that the more unidentical a worshipper is, the more likely she will experience bias, factual confirmation shows that vivid assert – which may report for more than the 50 per cent of united court prejudice activity – have very less chance of favourable outcome than single state. A representative of brief judgement commitment reveals that worshipper’s triumph on several claims. Getting the better of the courts unwilling to follow this superintendence needs the expansion and initiation of humanities research which set forth the subtlety cliché faced by complex suitor.
Isolation and characterization of phthalates from Brevibacterium mcbrellneri that cause cytotoxicity and cell cycle arrest
Creators: name: Rajamanikyam, Maheshwari
name: Vadlapudi, Varahalarao
name: Parvathaneni, Sai Prathima
name: Koude, Dhevendar
name: Sripadi, Prabhakar
name: Misra, Sunil
name: Amanchy, Ramars
name: Upadhyayula, Suryanarayana Murty
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2017
Subjects: Brevibacterium mcbrellneri
di-(2-ethylhexyl) phthalate
dibutyl phthalate
anti-bacterial
Mosquito larvicidal
cytotoxicity
cell cycle arrest

description: Bacteria belonging to the family Brevibacterieae are ubiquitous Gram positive organisms that are responsible for the feet odour and cheese aroma. Brevibacterium mcbrellneri is a relatively new member belonging to Brevibacterieae. In the current manuscript we discuss isolation of biologically active metabolites from Brevibacterium mcbrellneri. Two aromatic esters were isolated from Brevibacterium mcbrellneri by “Bioassay guided fractionation strategy” and identified as di-(2-ethylhexyl) phthalate and dibutyl phthalate by chemical characterization using biophysical techniques. The phthalate compounds show broad spectrum antibacterial activity and mosquito larvicidal activity. Mosquito larvicidal activity has been attributed to inhibition of acetylcholinesterase enzyme activity. These compounds were found to be cytotoxic in multiple cell lines causing cell cycle arrest in G1 phase.
description: EXCLI Journal; 16:Doc375; ISSN 1611-2156
Introduction to Digital Humanities Syllabus (Fall 2022)
Creators: name: Mapes, Kristen
Publisher: name: unknown
Year: 2022
Subjects: subject: Teaching
subject: Digital humanities

description: Syllabus for 2022 edition of DH285: Introduction to Digital Humanities, taught at Michigan State University as a required course in the undergraduate Digital Humanities minor. The course is a survey introduction to the field, has no prerequisites, and is open to students from any major. Twenty-eight students were in the course.
NFDI4Earth – the National Research Data Infrastructure for the Earth System Sciences Community
Creators: name: NFDI4Earth Consortium
Publisher: name: Zenodo
Year: 2025
Subjects: NFDI4Earth
NFDI4Earth Pilot
NFDI4Earth Incubator
NFDI4Earth Academy
NFDI4Earth Living Handbook
NFDI4Earth User Support Network
NFDI4Earth OneStop4All
NFDI4Earth Knowledge Hub
NFDI4Earth Label
NFDI4Earth FAIRness and Openness Commitment

description: The National Research Data Infrastructure (NFDI) aims to create a sustainable and networked infrastructure for research data and helps to overcome the challenges associated with the storage, management and processing, security, and provision of research data in Germany [1]. It thus plays an important role in promoting open science and the exchange of FAIR research data.  

NFDI4Earth is a community-driven process - its network comprises 66 partnering institutions from Universities, Research Organisations, Infrastructure Providers, Governmental Insitutions as well as Scientific Associations and Networks. It addresses the digital needs of Earth system science to understand the functioning and interactions within the Earth system and to tackle the most pressing challenges of global change (climate change, natural hazards, pollution, water scarcity, etc.).

NFDI4Earth provides researchers with FAIR, coherent, and open access to all relevant ES data, to innovative research data management and data science methods.

References: NFDI4Earth Consortium. (2025). NFDI4Earth – the National Research Data Infrastructure for the Earth System Sciences Community. Zenodo. https://doi.org/10.5281/zenodo.14832912
description: This work has been funded by the German Research Foundation (DFG) through the project NFDI4Earth (DFG project no. 460036893, https://nfdi4earth.de/) within the German National Research Data Infrastructure (NFDI, https://www.nfdi.de/).
Introduction to Digital Humanities Syllabus (Fall 2022)
Creators: name: Mapes, Kristen
Publisher: name: Humanities Commons
Year: 2022
Subjects: subject: Teaching
subject: Digital humanities

description: Syllabus for 2022 edition of DH285: Introduction to Digital Humanities, taught at Michigan State University as a required course in the undergraduate Digital Humanities minor. The course is a survey introduction to the field, has no prerequisites, and is open to students from any major. Twenty-eight students were in the course.
Sit-to-Stand Phases Detection by Inertial Sensors
Creators: name: DI MARCO, ANNA
Publisher: name: Universit� degli studi di Genova
Year: 2019

description: The Sit-to-Stand(STS) is defined as the transition from the sitting to standing
position. It is commonly adopted in clinical practice because musculoskeletal or
neurological degenerative disorders, as well as the natural process of ageing,
deter-mine an increased difficulty in rising up from a seated position.
This study aimed to detect the Sit To Stand phases using data from inertial sensors.
Due to the high variability of this movement, and, consequently the difficulty to define
events by thresholds, we used the machine learning. We collected data from 27
participants (13 females,24.37�3.32 years old). They wore 10 Inertial Sensors placed
on: trunk,back(L4-L5),left and right thigh, tibia, and ankles. The par-ticipants were
asked to stand from an height adjustable chair for 10 times. The STS exercises were
recorded separately. The starting and ending points of each phase were identified by
key events. The pre-processing included phases splitting in epochs. The features
extracted were: mean, standard deviation, RMS, Max and min, COV and first
derivative. The features were on the epochs for each sensor.
To identify the most fitting classifier, two classifier algorithms,K-nearest Neighbours(
KNN) and Support Vector Machine (SVM) were trained. From the data
recorded, four dataset were created varying the epochs duration, the number
of sensors. The validation model used to train the classifier. As validation
model, we compared the results of classifiers trained using Kfold and Leave
One Subject out (LOSO) models. The classifier performances were evaluated
by confusion matrices and the F1 scores.
The classifiers trained using LOSO technique as validation model showed
higher values of predictive accuracy than the ones trained using Kfold. The
predictive accuracy of KNN and SVM were reported below:
? KFold
? mean of overall predictive accuracy KNN: 0.75; F1 score: REST 0.86,
TRUNK LEANING 0.35,STANDING 0.60,BALANCE 0.54, SITTING 0.55
? mean of overall predictive accuracy SVM: 0.75; F1 score: REST 0.89,
TRUNK LEANING 0.48,STANDING 0.48,BALANCE 0.59, SITTING 0.62
? LOSO
? mean of overall predictive accuracy KNN: 0.93; F1 score: REST 0.96,
TRUNK LEANING 0.79,STANDING 0.89,BALANCE 0.95, SITTING 0.88
? mean of overall predictive accuracy SVM: 0.95; F1 score phases:
REST 0.98, TRUNK LEANING 0.86,STANDING 0.91,BALANCE 0.98,
SIT-TING 0.92
Black soldier fly larvae efficiently bioconvert the organic fraction of municipal solid waste thanks to their midgut functional plasticity
Creators: name: Bruno, D.
name: Bonelli, M.
name: Valoroso, M.C.
name: Roma, D.
name: Montali, A.
name: Pellegrino, M.G.
name: Marzari, M.
name: Caccia, S.
name: Tettamanti, G.
name: Casartelli, M.
Publisher: name: Brill Online
Year: 2024
Subjects: classificationCode: 309999
subject: Other agricultural, veterinary and food sciences not elsewhere classified

description: The saprophagous larvae of Hermetia illucens show promising potential as effective agents for bioconverting organic waste and by-products into valuable biomass. Their capability to efficiently transform organic substrates, varying in nutrient content, origin, texture, and moisture, is strictly correlated with the morphofunctional complexity of their digestive system and the associated microbiota. In addition, post-ingestion mechanisms are set in motion to regulate the midgut activity depending on the feeding substrate, thus ensuring the nutritional requirements of the larvae. This study aims to assess the capability of H. illucens larvae to grow and biotransform the organic fraction of municipal solid waste (OFMSW). In particular, the larvae were reared on substrates mimicking the OFMSW with different nutrient content, and their growth and bioconversion performance, as well as the quality of larval and pupal biomass were evaluated. Our results demonstrate that the nutritional composition of the rearing substrates had minimal impact on the efficiency of the bioconversion process and on the protein, lipid, and chitin content of the insect biomass. This was due to a fine transcriptional regulation of genes encoding enzymes involved in protein, polysaccharide, and lipid digestion in midgut cells. As a consequence, larvae reared on OFMSW with the lowest protein, starch, and lipid content exhibited a significant increase in protease, amylase, and lipase activities. Overall, this study highlights the value of H. illucens larvae in valorising the OFMSW, demonstrating that variations in its composition do not significantly affect the quality of the bioconversion process. These findings hold significant practical implications as current strategies for OFMSW treatment remain unsatisfactory and innovative approaches are needed to enhance bio-waste recycling and reduce the environmental impact of waste management.
Limbaj Și Context = Speech And Context, No.1, 2009
Creators: name: Cosciug, Angela
Publisher: name: Zenodo
Year: 2009
Subjects: speech
journal
linguistics
semiotics
literary science
open access
limbaj si context
Republic of Moldova
Republica Moldova

description: Speech and Context International Journal of Linguistics, Semiotics and Literary Science (SCIJLSLS) is an open access, peer reviewed (double blind reviewed) journal which is indexed in many prestigious international databases, directories, lists etc. (see Journal Indexing and Registration by databases types or Journal Indexing and Registration by countries). It appears there like Limbaj şi context or Speech and Context International Journal of Linguistics, Semiotics and Literary Science. The journal is founded in 2009 by Angela COŞCIUG, Associate Professor, Ph.D., at Alecu Russo State University of Bălţi, Republic of Moldova. From 2010, the journal is published in cooperation with the administration of Basel (Switzerland). From January 2009 till May 2013 the journal published materials in English, French, German, Spanish, Portuguese, Romania, Russian and Ukrainian. From May 2013 it publishes materials only in English.
description: Limbaj și context = Speech and Context : Rev. de lingvistică,  semiotică și șt. literară/Univ. de Stat "Alecu Russo".-  Bălți, 2009.- Nr.1.-p. 147.- ISSN 1857-4149
TAQRIZ AKADEMIK YOZUV JANRI SIFATIDA
Creators: name: Begimov, Odil
Publisher: name: Zenodo
Year: 2025

description: Ma’lumki, akademik yozuv muayyan funktsiyalarni bajaradigan turli janrdagi matnlarni o’z ichiga oladi. Ushbu funktsiyalardan biri – tanqidiy baholash, ya’ni ilmiy tadqiqot natijasida yaratilgan maqola, dissertatsiya va unung avtoreferati, shuningdek, monografiya, darslik, oʻquv qoʻllanmalari kabi ilmiy-ijodiy ishlarni taqriz qilish uchun xosdir. Maqolada taqrizning akademik yozuv janri sifatidagi  ahamiyati, maqsad va vazifalari haqida fikr yuritiladi.
AGENT-BASED MODEL AND SIMULATIONS OF THE MANAGEMENT OF PORTS: THE IMPORT PROCESSES AT THE PORT OF GENOVA
Creators: name: SENTURK, ONUR
Publisher: name: Universit� degli studi di Genova
Year: 2019

description: This thesis addressed to use of Agent-Based Modelling (ABM) for the development and implementation of the import process of goods in a port that is suitably applied to help, plan, structure the development of the port model. The main goal of the modelling and implementation was to reach to fruition as more organized, fast and efficient complex logistics network, through development policies. To this purpose, I developed an agent-based model (ABM) of a port that is populated by the real main actors (stakeholders) whose are involved in the port activities such as maritime, customs, financial police etc. The model of the port simulates the actual port processes, i.e. acceptance of the goods, sending them, controlling of the legality, or not to import goods, the transportation planning etc. Agent-based models (ABMs) are being used in modelling in economies as complex systems that is a relatively recent approach in economies [62]. It has increasingly been attracting many scholars belonging to several sub-fields, becoming both a complement and a substitute for more traditional economic-modeling methodologies [62]. We can mention that ABMs are considered as a valid and effective competitor of standard Dynamic Stochastic General Equilibrium (DSGE) models in macroeconomics [26]. The main advantages of using ABMs arrive two main additional values if we compare it with its equivalent systems. ABM provides more descriptive richness, as they characterize ecologies of agents, locally interacting through non-obvious network structures, learning using incomplete information, and competing within imperfect markets. Second, the modeler developing an ABM has typically more flexibility in both input and output validation of its model [34].
Ports have an integral role of our economy, they are strategic places of exchange, and especially over the last few decades and with the phenomenon of globalization, the ports are a reality in continuous movement and growth. Therefore, they are operating places of extreme complexity, especially in their logistics functions of transport management.
The thesis discusses the business process is implemented for developing a computer supported management tool to handle the port activities flow. The tool is designed for the integration in a virtual infrastructure that allows an advanced operational management of port traffics. By modelling the time documentation according to the specification of the Genoa case, the business case of the port of Genoa is tested.
Results show that the mechanism implemented simulates the actual process. Moreover some bottleneck are discovered, such as delays to the handling of the containers and queues formation due to missing documentation or documentation with errors or not ready.
Additional file 7 of Circular RNA METTL9 contributes to neuroinflammation following traumatic brain injury by complexing with astrocytic SND1
Creators: name: Huang, Chunling
name: Sun, Lulu
name: Xiao, Chenyang
name: You, Wenjun
name: Sun, Li
name: Wang, Siye
name: Zhang, Zhijun
name: Liu, Su
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health

description: Additional file 7: Table S7. RT-PCR and agarose gel electrophoresis of 7 circRNAs which were amplified by specific primers.
Evaluating the cellular roles of the lysine acetyltransferase Tip60 in cancer: A multi-action molecular target for precision oncology
Creators: name: Zohourian Moftakharoleslam, Nazanin
name: Coll, Erin
name: Dever, Muiread
name: Sheahan, Anna
name: Burns-Lane, Petra
name: BROWN, JAMES
Publisher: name: University of Limerick
Year: 2025
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences

description: Precision (individualized) medicine relies on the molecular profiling of tumors’ dysregu?lated characteristics (genomic, epigenetic, transcriptomic) to identify the reliance on key pathways (including genome stability and epigenetic gene regulation) for viability or growth, and then utilises targeted therapeutics to disrupt these survival-dependent pathways. Non-mutational epigenetic changes alter cells’ transcriptional profile and are a key feature found in many tumors. In contrast to genetic mutations, epigenetic changes are reversable, and restoring a normal epigenetic profile can inhibit tumor growth and progression. Lysine acetyltransferases (KATs or HATs) protect genome stability and integrity, and Tip60 is an essential acetyltransferase due to its roles as an epigenetic and transcriptional regulator, and as master regulator of the DNA double-strand break response. Tip60 is commonly downregulated and mislocalized in many cancers, and the roles that mislocalized Tip60 plays in cancer are not well understood. Here we categorize and discuss Tip60-regulated genes, evaluate Tip60-interacting proteins based on cellular localization, and explore the therapeutic potential of Tip60-targeting compounds as epigenetic inhibitors. Understanding the multiple roles Tip60 plays in tumorigenesis will improve our understanding of tumor progression and will inform therapeutic options, including informing potential combinatorial regimes with current chemotherapeutics, leading to improvements in patient outcomes.
Models for GREEN-CODE Paper
Creators: name: Ilager, Shashikant
name: Briem, Lukas
name: Brandic, Ivona
Publisher: name: Zenodo
Year: 2024

description: Large Language Models (LLMs) are becoming integral to daily life, showcasing their vast potential across various Natural Language Processing (NLP) tasks. Beyond NLP, LLMs are increasingly used in software development tasks, such as code completion, modification, bug fixing, and code translation. Software engineers widely use tools like GitHub Copilot and Amazon Q, streamlining workflows and automating tasks with high accuracy. While the resource and energy intensity of LLM training is often highlighted, inference can be even more resource-intensive over time, as it's a continuous process with a high number of invocations. Therefore, developing resource-efficient alternatives for LLM inference is crucial for sustainability. This work proposes GREEN-CODE, a framework for energy-aware code generation in LLMs. GREEN-CODE performs dynamic early exit during LLM inference. We train a Reinforcement Learning (RL) agent that learns to balance the trade-offs between accuracy, latency, and energy consumption. Our approach is evaluated on two open-source LLMs, Llama 3.2 3B and OPT 2.7B, using the JavaCorpus and PY150 datasets. Results show that our method reduces the energy consumption between 23--50% on average for code generation tasks without significantly affecting accuracy.
Additional file 1 of Lipid parameters, adipose tissue distribution and prognosis prediction in chronic kidney Disease patients
Creators: name: Chen, Hui-fen
name: Xiao, Bing-jie
name: Chen, Lin-yi
name: OuYang, Wen-wei
name: Zhang, Xian-long
name: He, Zhi-ren
name: Fu, Li-zhe
name: Tang, Fang
name: Tang, Xiao-na
name: Liu, Xu-sheng
name: Wu, Yi-fan
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Computational Biology

description: Supplementary Material 1
Studio dei fattori di crescita coinvolti nello sviluppo tissutale e nella deposizione di matrice extracellulare del porifero Chondrosia reniformis (Nardo, 1847) con metodi immunoistochimici e di biologia molecolare.
Creators: name: GALLUS, LORENZO
Publisher: name: Universit� degli studi di Genova
Year: 2019

description: Tissue repair is an adaptive and common metazoan response characterized by various cellular mechanisms and complex signalling networks that involve several growth factors and cytokines. In higher animals, the transforming growth factor-? superfamily members (TGF-? SF) signalling plays a fundamental role in wound healing. Aim of this thesis was to assess the involvement of TGF-? SF members in lower invertebrate tissue regeneration. To achieve this result, sequence that code for putative TGF ligands and receptors were isolated from the transcriptome of a marine sponge Chondrosia reniformis, transcriptome that was previously obtained in the laboratory hosting the research object of this doctorate?s work.
C. reniformis is a marine Demospongiae, without siliceous spicules, but with a robust collagen scaffold. Since its identification as a true poriferous by Giovanni Domenico Nardo in the 1847, it has been the subject of study by zoologists, ecologists and more recently biotechnologists interested in several of its biological peculiarities.
In the first part of the research we identified six transcripts that coded for TGF superfamily ligands and two sequences that coded for TGF superfamily receptors. Phylogenetically, the TGF ligands of C. reniformis could not be grouped in a TGF-? SF clades and consequently these ligands presumably evolved independently, while the TGF receptors clustered in the Type I receptor group.
During the research activities we examined the gene expression of these transcripts and the cell regeneration processes from a microscopic morphological point of view in a particular type of sponge regenerating tissue explants called fragmorph. The fragmorphs are essentially coring, in our case of 9 millimeters in diameter, made perpendicularly to the upper face of the sponge.
The data obtained indicated that three ligands (TGF-1, -3 and -6) could be involved in staminal cell maintenance, since they were mainly expressed during early regeneration, while two (TGF-4 and TGF-5) were considered pro-differentiating factors, since they were strongly upregulated during late regeneration. In presence of 0.1mM SB431542, a strong TGF receptors inhibitor, the exopinacoderm restoring of the fragmorph resulted blocked, attesting the functional involvement of TGF-pathway in tissue regeneration also in these early evolved animals.
Additional file 2 of Lipid parameters, adipose tissue distribution and prognosis prediction in chronic kidney Disease patients
Creators: name: Chen, Hui-fen
name: Xiao, Bing-jie
name: Chen, Lin-yi
name: OuYang, Wen-wei
name: Zhang, Xian-long
name: He, Zhi-ren
name: Fu, Li-zhe
name: Tang, Fang
name: Tang, Xiao-na
name: Liu, Xu-sheng
name: Wu, Yi-fan
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Computational Biology

description: Supplementary Material 2
Taxonomical characterization of Posidonia oceanica banquettes and driftwoods-related fauna
Creators: name: ZINNI, MATTEO
Publisher: name: Universit� degli studi di Genova
Year: 2019

description: The proposed work provide a multilevel approach for two beach-related allocthonous inputs: P.
oceanica banquettes and driftwoods. Since beaches are commonly perceived as true deserts, their
biological values and their ecological importance are often underestimated leading even more
inadequate management strategies.
Banquettes - more related to seasonal cycles of P. oceanica - have been studied through coil
sampling and Berlese-Tullgren extraction, focusing mainly on the infaunal arthropods.
Fauna associated to driftwoods has been surveyed through pitfall trapping, aiming to study more
surface related organisms.
The taxonomical characterization has been followed by estimation of species richness according to
the most recent frameworks, to provide an insight to these high-diverse biocenosis inferring
meaningful differences within and between sampled sites.
The observed diversity has been characterized through a qualitative as well as quantitative
approach. Three widely used ecological index, as well as Collembola lifeforms have been applied to
study the composition and the structure of beach related fauna.
Moreover, as shoreline environments undergo increasing anthropocentric pressure resulting from
demographic growth and recreational-only oriented management, the response of the studied fauna
to several environmental factors has been analysed through linear models and community
composition analysis.
The number of observed species is not directly related to the individual abundance recorded for
each site.The observed - and often underestimated - taxonomical richness is determined by socalled
rare species, which carry most of the diversity information. Nevertheless the composition of
the observed communities change in time and space under the combined effects of several
enviromental variables.
IEC 61850: a safety and security analysis in industrial multiprotocol networks
Creators: name: ROCCA, LUCA
Publisher: name: Universit� degli studi di Genova
Year: 2019

description: Nowadays, Ethernet is the most popular technology in digital communication thanks to its flexibility and worldwide spread. This is the reason why the main industrial communication protocols today are based on Ethernet. Everybody says that Ethernet supports a large amount of different protocols, but only accurate laboratory tests can make this assumption true. Tests are performed on a hybrid network using three protocols: Profinet, IEC 61850 and TCP/IP. The combination of these three protocols represents an ideal industrial application where process automation, substation automation and general purpose data sharing interact. However, a shared network can be the cause of a drop in terms of safety and security in the industrial plant network.
Safety has always played an important role in the life of human beings and the environment. The safety of process control systems is standardized in IEC 61508 and IEC 61784-3, but this is not the same in the area of substation automation system. Several tests are performed to prove if IEC 61850 (the standard protocol for substation automation) meets the requirements stated in IEC 61508 and if it can be used for safety-related functions.
Security issues for industrial plants have become increasingly relevant during the past decade as the industry relied more and more on communication protocols. This work examines the security issues for IEC 61850 addressed by IEC 62351-6 providing a deepening for a secure GOOSE communication. The major issue implementing such a standard remains the computational power requested by the SHA algorithm in low-powered devices. As no manufacturer has made available a device implementing secure GOOSE communication yet, this solution is discussed only from a theoretical point of view. After that, it is presented a security test on the GOOSE communication during which the security issues of such a communication are exploited. This test aims to show what consequences may occur when a packet artfully created is injected within the IEC 61850 network. In the last part of this section, some countermeasures to mitigate such an issue are provided.
Guidelines for Researchers on Personal Data Protection in Scientific Research Activities at Iscte
Creators: name: Iscte – Instituto Universitário de Lisboa
Publisher: name: Zenodo
Year: 2022

description: Iscte-Instituto Universitário de Lisboa (hereinafter Iscte) is assigned with carrying out scientific research and study cycles, including masters and doctorates, in which scientific or historical research activities are pursued.The processing of personal data for scientific research purposes is understood in a broad sense, covering, for example, technological development and demonstration, fundamental or applied research, historical research, research for genealogical purposes or research funded by the private sector.1The researchers as well as the lecturers, employees, students, and collaborators involved in research activities of Iscte are duty-bound to comply with ethical standards concerning respect for the privacy of participants in research work and the legislation on data protection in force.This document summarises Iscte’s perspective on the legislation on data protection for scientific and historical research, in particular the framework arising from the General Data Protection Regulation (GDPR) and Law 59/2019 of 08/08 – Implementing Law, in the Portuguese legal system, of the GDPR.
Orientações aos Investigadores sobre Proteção de Dados Pessoais no Iscte
Creators: name: Iscte – Instituto Universitário de Lisboa
Publisher: name: Zenodo
Year: 2022

description: Constituem atribuições do Iscte-Instituto Universitário de Lisboa (adiante designado Iscte) realizar investigação científica e ciclos de estudo, incluindo mestrados e doutoramentos, onde se desenrolam atividades de investigação científica ou histórica que tratam dados pessoais.O tratamento de dados pessoais para fins de investigação científica entende-se em sentido lato, abrangendo, por exemplo, o desenvolvimento tecnológico e a demonstração, a investigação fundamental ou aplicada, a investigação histórica, a investigação para fins genealógicos ou a investigação financiada pelo setor privado. São deveres dos investigadores, e também dos docentes, funcionários, alunos e colaboradores envolvidos em atividades de investigação do Iscte, cumprir padrões éticos de respeito pela privacidade dos participantes em trabalhos de investigação e a legislação de proteção de dados em vigor.Este documento resume a perspetiva do Iscte relativamente à legislação de proteção de dados para a investigação científica e histórica, em particular o enquadramento decorrente do Regulamento Geral sobre a Proteção de Dados (RGPD) e da Lei 59/2019, de 08/08 – Lei de Execução, na ordem jurídica nacional, do RGPD.
Additional file 3 of Lipid parameters, adipose tissue distribution and prognosis prediction in chronic kidney Disease patients
Creators: name: Chen, Hui-fen
name: Xiao, Bing-jie
name: Chen, Lin-yi
name: OuYang, Wen-wei
name: Zhang, Xian-long
name: He, Zhi-ren
name: Fu, Li-zhe
name: Tang, Fang
name: Tang, Xiao-na
name: Liu, Xu-sheng
name: Wu, Yi-fan
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Computational Biology

description: Supplementary Material 3
Graphical Models for Multivariate Time-Series
Creators: name: TOMASI, FEDERICO
Publisher: name: Universit� degli studi di Genova
Year: 2019

description: Gaussian graphical models have received much attention in the last years, due
to their flexibility and expression power. In particular, lots of interests have
been devoted to graphical models for temporal data, or dynamical graphical
models, to understand the relation of variables evolving in time. While powerful
in modelling complex systems, such models suffer from computational
issues both in terms of convergence rates and memory requirements, and may
fail to detect temporal patterns in case the information on the system is partial.
This thesis comprises two main contributions in the context of dynamical
graphical models, tackling these two aspects: the need of reliable and fast
optimisation methods and an increasing modelling power, which are able to
retrieve the model in practical applications. The first contribution consists in a
forward-backward splitting (FBS) procedure for Gaussian graphical modelling
of multivariate time-series which relies on recent theoretical studies ensuring
global convergence under mild assumptions. Indeed, such FBS-based implementation
achieves, with fast convergence rates, optimal results with respect
to ground truth and standard methods for dynamical network inference. The
second main contribution focuses on the problem of latent factors, that influence
the system while hidden or unobservable. This thesis proposes the novel
latent variable time-varying graphical lasso method, which is able to take into
account both temporal dynamics in the data and latent factors influencing
the system. This is fundamental for the practical use of graphical models,
where the information on the data is partial. Indeed, extensive validation of
the method on both synthetic and real applications shows the effectiveness of
considering latent factors to deal with incomplete information.
Evaluating the impact of intracortical microstimulation on distant cortical brain regions for neuroprosthetic applications
Creators: name: AVERNA, ALBERTO
Publisher: name: Universit� degli studi di Genova
Year: 2019

description: Enhancing functional motor recovery after localized brain injury is a widely recognized priority in healthcare as disorders of the nervous system that cause motor impairment, such as stroke, are among the most common causes of adult-onset disability. Restoring physiological function in a dysfunctional brain to improve quality of life is a primary challenge in scientific and clinical research and could be driven by innovative therapeutic approaches. Recently, techniques using brain stimulation methodologies have been employed to promote post-injury neuroplasticity for the restitution of motor function. One type of closed-loop stimulation, i.e., activity-dependent stimulation (ADS), has been shown to modify existing functional connectivity within either healthy or injured cerebral cortices and used to increase behavioral recovery following cortical injury.
The aim of this PhD thesis is to characterize the electrophysiological correlates of such behavioral recovery in both healthy and injured cortical networks using in vivo animal models.
We tested the ability of two different intracortical micro-stimulation protocols, i.e., ADS and its randomized open-loop version (RS), to potentiate cortico-cortical connections between two distant cortical locations in both anaesthetized and awake behaving rats. Thus, this dissertation has the following three main goals: 1) to investigate the ability of ADS to induce changes in intra-cortical activity in healthy anesthetized rats, 2) to characterize the electrophysiological signs of brain injury and evaluate the capability of ADS to promote electrophysiological changes in the damaged network, and 3) to investigate the long-term effects of stimulation by repeating the treatment for 21 consecutive days in healthy awake behaving animals.
The results of this study indicate that closed-loop activity-dependent stimulation induced greater changes than open-loop random stimulation, further strengthening the idea that Hebbian-inspired protocols might potentiate cortico-cortical connections between distant brain areas. The implications of these results have the potential to lead to novel treatments for various neurological diseases and disorders and inspire new neurorehabilitation therapies.
Supplemental Material, DI_SOM_R1 - Rising Ethnic Diversity in the United States Accompanies Shifts Toward an Individualistic Culture
Creators: name: Huynh, Alex C.
name: Grossmann, Igor
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental Material, DI_SOM_R1 for Rising Ethnic Diversity in the United States Accompanies Shifts Toward an Individualistic Culture by Alex C. Huynh and Igor Grossmann in Social Psychological and Personality Science
Additional file 4 of Lipid parameters, adipose tissue distribution and prognosis prediction in chronic kidney Disease patients
Creators: name: Chen, Hui-fen
name: Xiao, Bing-jie
name: Chen, Lin-yi
name: OuYang, Wen-wei
name: Zhang, Xian-long
name: He, Zhi-ren
name: Fu, Li-zhe
name: Tang, Fang
name: Tang, Xiao-na
name: Liu, Xu-sheng
name: Wu, Yi-fan
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Computational Biology

description: Supplementary Material 4
Additional file 5 of Lipid parameters, adipose tissue distribution and prognosis prediction in chronic kidney Disease patients
Creators: name: Chen, Hui-fen
name: Xiao, Bing-jie
name: Chen, Lin-yi
name: OuYang, Wen-wei
name: Zhang, Xian-long
name: He, Zhi-ren
name: Fu, Li-zhe
name: Tang, Fang
name: Tang, Xiao-na
name: Liu, Xu-sheng
name: Wu, Yi-fan
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Computational Biology

description: Supplementary Material 5