cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Development of transgenic Alzheimer's disease mouse model to evaluate therapeutic approaches using Adeno-Associated virus (AAV)
Creators: name: Fanous, Marco
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: Alzheimer’s disease is a progressive neurodegenerative disease that affects million of Americans every year for which no cure exists. Alzheimer’s disease (AD) pathology involves the accumulation of tau protein isoforms and amyloid-β (Aβ) in brain tissue leading to degradation of cortical brain regions such as the hippocampus. It is hypothesized that an imbalance between the production and clearance of tau and Aβ leads to plaque accumulation and neuronal cell death. Clearance is achieved via glymphatic circulation which is facilitated by aquaporin 4 (Aqp4) water channel proteins, and it is believed that diminished ISF bulk flow leads to accumulation of tau and Aβ. Here, a new mouse model was generated utilizing strategy crosses between an existing AD mouse model (3xTg-AD) and a Aqp4 KO mouse model, predicting that this new model would show an accelerated AD phenotype characterized by increased tau deposits in mouse cortical regions. In parallel, gene therapy using an AAV9-GFAP-Aqp4 construct was used to evaluate the therapeutic efficacy of Aqp4 expression on tau levels. The double transgenic mouse (3xTg-AD;Aqp4 KO) was genotyped and characterized via western blot. We observed that the 3xTg-AD;Aqp4 KO mice exhibit significantly more tau protein levels at a younger age compared with older 3xTg-AD mice. We also observed greater total tau levels in the hippocampus compared to whole brain tissue. Gene therapy on 3xTg-AD;Aqp4 KO mice treated with an AAV9-GFAP-Aqp4 construct resulted in a reduction of tau specifically in the hippocampus. Further characterization using immunohistochemistry, staining for different proteins and metabolites, and comparison of charactersitic neurodegenerative pathology with other AD mouse models is necessary to fully understand the pathology of this new (3xTg-AD;Aqp4 KO) mouse model. These findings provide evidence that clearance of interstitial fluid/metabolic waste including tau protein is impacted by the aquaporin 4 water channel, and that Aqp4 may serve as a thereputic candidate for future trials investigating treatments for neurodegenerative diseases.
Performance analysis of tensor-oriented runtimes for database workloads
Creators: name: Arden, Bryce Sander
name: 0000-0003-1467-9467
Publisher: name: The University of Texas at Austin
Year: 2022
Subjects: Database
Machine learning
Dataflow

description: Artificial Intelligence workloads have grown in popularity over the last decade, but database query processing runtimes are also evolving to keep up with increased demand. This report investigates whether the memory and compute profiles of Data Science/Analytics applications can benefit from techniques used to optimize Machine Learning workloads. In other words, expressing database operators as data-centric coarse-grained kernels with dynamic shape dimensions may enable the merging of Machine Learning (ML) and query runtimes into one. Since database applications are traditionally optimized for CPU performance and heterogeneous computing environments are becoming the norm, performance is being left on the table if SQL queries continue to only use the CPU. This report attempts to reuse state-of-the-art tensor-based runtimes for query/database workloads and evaluate the performance against traditional data-analytics frameworks. Reasoning about scheduling/execution primitives in a composable way can unlock new opportunities for system-level performance optimizations (e.g., eliminating unnecessary materialization, eliding compute that is not used downstream, etc.). Even though workload profiles and work dispatch strategies between Machine Learning (ML) and Data Analytics appear similar at first glance, differences in the type system, compute characteristics, and expressiveness in the program description push these domains farther apart instead of closer together. Although current ML frameworks do not provide compelling performance on database-style workloads, there is room in the ecosystem to support much better interoperability between these two domains.
Otoliths of marine fishes record evidence of low oxygen, temperature and pH conditions of deep Oxygen Minimum Zones
Creators: name: Cavole, Leticia
name: E. Limburg, Karin
name: D. Gallo, Natalya
name: Salvanes, Anne Gro Vea
name: Ramirez-Valdez, Arturo
name: Levin, Lisa A
name: Aburto-Oropeza, Octavio
name: Hertwig, Andreas
name: Liu, Ming-Chang
name: McKeegan, Kevin D.
Publisher: name: figshare
Year: 2022
Subjects: subject: 60806 Animal Physiological Ecology
subject: FOS: Biological sciences
subject: 60306 Evolutionary Impacts of Climate Change
subject: Marine Biology
subject: Zoology
subject: 40501 Biological Oceanography
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 50101 Ecological Impacts of Climate Change
subject: 50202 Conservation and Biodiversity
subject: Environmental Science
subject: Oceanography
subject: 40503 Physical Oceanography

description: The deep-sea is rapidly losing oxygen, with profound implications for marine organisms. Within Eastern Boundary Upwelling Systems, such as the California and the Benguela Current Ecosystems, an important question is how the ongoing expansion, intensification and shoaling of Oxygen Minimum Zones (OMZs) will affect deep-sea fishes throughout their lifetimes. One of the first steps to filling this knowledge gap is through the development of tools and techniques to track fishes’ exposure to hypoxic (< 22-45 µmol kg-1), low-temperature (~ 4-10°C) and low-pH (~ 7.5) waters when inhabiting OMZs. Here, we examine if the otoliths of deep-sea fishes living in OMZs exhibit distinct patterns of elemental and isotopic composition, which could be used to monitor their exposure history to severely hypoxic and low-pH waters. We hypothesize that the unique biogeochemistry of OMZs (i.e., low-oxygen, low-pH, and the presence of dissolved elements) will impart unique elemental and isotopic signatures upon the otoliths of both long-lived and short-lived deep-sea fishes living within it. We analyzed the otoliths of six deep-sea fish species from three OMZ regions: the Southern California Bight and the Gulf of California in the Northeast Pacific Ocean, and the Namibian shelf in the Southeast Atlantic Ocean. Three complementary techniques were applied: laser ablation inductively coupled plasma mass spectrometry, secondary ion mass spectrometry and scanning X-ray fluorescence microscopy. We observed that deep-water OMZ-dwelling fishes spanning a range of life-history traits (e.g., longevity, maximum size, growth rate, parental investment and thermal history inferred by δ18O) exhibited a common elemental fingerprint (with respect to Sr:Ca, Mn:Ca, Ba;Ca and Mg:Ca) when compared to a shallow-water marine fish from better-oxygenated waters. Our findings suggest that the underlying mechanism for the common elemental fingerprinting of otoliths of OMZ-dwelling fishes is attributed to the unique biogeochemistry found on the margins of these highly productive upwelling systems as well as the physiological constraints resident organisms are perennially exposed to, including low oxygen, pH and temperature conditions.
Linear sequential dynamical systems, incidence algebras, and Möbius functions
Creators: name: Chen, Ricky X. F.
name: Reidys, Christian M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 06A11, 70K05

description: A sequential dynamical system (SDS) consists of a graph, a set of local functions and an update schedule. A linear sequential dynamical system is an SDS whose local functions are linear. In this paper, we derive an explicit closed formula for any linear SDS as a synchronous dynamical system. We also show constructively, that any synchronous linear system can be expressed as a linear SDS, i.e. it can be written as a product of linear local functions. Furthermore, we study the connection between linear SDS and the incidence algebras of partially ordered sets (posets). Specifically, we show that the Möbius function of any poset can be computed via an SDS, whose graph is induced by the Hasse diagram of the poset. Finally, we prove a cut theorem for the Möbius functions of posets with respect to certain chain decompositions.
description: [v4] updated title, discussion section added
Determining the mechanism by which NK cells regulate T cell responses to infection
Creators: name: Lund, Makayla
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: Chronic viral infections, such as HIV and HCV, are common throughout the developed and developing world and cause devastating illness. There is a need to better understand how to engage the adaptive immune system to control or limit infection to reduce the negative health consequences of infection. Natural killer (NK) cells contribute to immune defense against many virus infections by recognizing and killing infected cells. However, we have identified an inhibitory role for NK cells in relation to antiviral T cell activity during lymphocytic choriomeningitis virus (LCMV) infection in mice. The underlying mechanism(s) by which NK cells limit virus-specific T cell responses is unclear, but two hypothesis have been proposed: either NK cells recognize and kill activated T cells, a process countered by interferon signaling into T cells, or NK cells impair the induction of T cell responses. We have previously shown that type-2 interferon (IFNg), like type-1 interferon, acts directly on T cells to promote antiviral T cell responses to acute LCMV infection. Here, we examined whether IFNg acts directly on T cells to protect them from the inhibitory effects of NK cells. We compared the accumulation of virus-specific IFNgR+/+ and IFNgR-/- T cells in the same infected mice, expecting that IFNgR-/- T cells would be removed by NK cells. We observed that NK cell depletion increased the number of both cell populations and there was no preferential rescue of IFNgR-/- T cells, suggesting that IFNgR signaling to T cells does not protect them from NK cell suppression. We also considered whether NK cells inhibit antigen presentation by Antigen Presenting Cells (APCs) to curtail the induction of T cell responses. We measured the ability of APCs from infected mice to process soluble antigen utilizing fluorescent DQ-OVA and flow cytometry. Our data suggest that NK cell depletion improves APC processing of DQ-OVA, especially in monocyte populations. These data suggest that NK depletion allows for better stimulation of T cells by APCs, leading to greater outgrowth of T cells during infection. Thus, NK cells limit the induction of antiviral T cells, a process that may be conserved for T cell responses to chronic human virus infections.
Supplementary Information from Paracrine interactions through FGFR1 and FGFR2 receptors regulate the development of preimplantation mouse chimaeric embryo
Creators: name: Krawczyk, Katarzyna
name: Wilczak, Katarzyna
name: Szczepańska, Katarzyna
name: Maleszewski, Marek
name: Suwińska, Aneta
Publisher: name: The Royal Society
Year: 2022
Subjects: Cell Biology
Developmental Biology

description: Supplementary materials including raw data on embryos used for analyses, additional figures corresponding to those in the main text and list of TaqMan Assays that were used to determine gene expression levels.
Euphorbia prostrata Aiton 1789
Creators: name: Mifsud, Stephen
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Malpighiales
Euphorbiaceae
Euphorbia
Euphorbia prostrata

description: Euphorbia prostrata Aiton (1789: 139) [Fig.1D]
 Origin: North America but nowadays widespread as a pantropical and subtropical weed after being introduced in many parts of the Old World (Smith & Tutin 1968, Steinmann et al. 2016, Hyde et al. 2017, Tropicos 2017)
Occurrences in Europe and the Mediterranean area: Throughout most of south Europe (from the Azores and the Canary islands to Crete and Israel) but apparently missing in north Africa and north Europe (Smith & Tutin 1968, Euro+Med 2006–2017, DAISIE 2008).
Introduction in Malta: Likely through import of potted plants for horticulture purposes.
 Habitat: Roadsides, curbs and paved ground, naturalising locally in urban areas, scarce, but possibly misidentified with other closely related species such as E. serpens.
Invasiveness: Casual occurrence and naturalised locally in few areas but likely increasing where it is found. Invasive potential low, not observed in natural ecosystems.
 First record: Not previously recorded, with the exception of Weber & Kendzior (2006) who reported it by mistake (illustration in fact shows a glabrous plant of E. serpens). Observed by the present author at Baħar iċ- Ċaghaq on 18 September 2014.
Flowering: June–November.
Morphological observations: Density of pilosity varies, but always present as a longitudinal band at the corners of the fruit leaving a glabrous area in between. The seeds with 6–7 transversal ridges is very distinctive for the species.
Chromosome number: 2n = 18 (Benedì & Orell 1992).
description: Published as part of Mifsud, Stephen, 2018, Contribution to the flora of the Maltese Islands: Euphorbia subg. Chamaesyce and Euphorbia exigua s. l. (Euphorbiaceae), pp. 153-166 in Phytotaxa 372 (2) on page 159, DOI: 10.11646/phytotaxa.372.2.2, http://zenodo.org/record/13728780
Realizations of $κ$-Minkowski space, Drinfeld twists and related symmetry algebras
Creators: name: Juric, Tajron
name: Meljanac, Stjepan
name: Pikutic, Danijel
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Realizations of $κ$-Minkowski space linear in momenta are studied for time-, space- and light-like deformations. We construct and classify all such linear realizations and express them in terms of $\mathfrak{gl}(n)$ generators. There are three one-parameter families of linear realizations for time-like and space-like deformations, while for light-like deformations, there are only four linear realizations. The relation between deformed Heisenberg algebra, star product, coproduct of momenta and twist operator is presented. It is proved that for each linear realization there exists Drinfeld twist satisfying normalization and cocycle conditions. $κ$-deformed $\mathfrak{igl}(n)$-Hopf algebras are presented for all cases. The $κ$-Poincaré-Weyl and $κ$-Poincaré-Hopf algebras are discussed. Left-right dual $κ$-Minkowski algebra is constructed from the transposed twists. The corresponding realizations are nonlinear. All known Drinfeld twists related to $κ$-Minkowski space are obtained from our construction. Finally, some physical applications are discussed.
description: 35 pages, improved version accepted for publication in EPJC
Lord of My Heart
Creators: name: Grand, Shannon
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: The poems in Lord of My Heart address the relationships between family, gender, and power, as well as the body. The relationship of the body to the self and to others is also related to a question of language, storytelling, and genealogy. How do our origins impact who we are and who we become? How much control do we have over the self?
Disease-induced resource constraints can trigger explosive epidemics
Creators: name: Böttcher, Lucas
name: Woolley-Meza, Olivia
name: Araújo, Nuno A. M.
name: Herrmann, Hans J.
name: Helbing, Dirk
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Biological Physics (physics.bio-ph)
subject: Computational Physics (physics.comp-ph)
subject: Populations and Evolution (q-bio.PE)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Advances in mathematical epidemiology have led to a better understanding of the risks posed by epidemic spreading and informed strategies to contain disease spread. However, a challenge that has been overlooked is that, as a disease becomes more prevalent, it can limit the availability of the capital needed to effectively treat those who have fallen ill. Here we use a simple mathematical model to gain insight into the dynamics of an epidemic when the recovery of sick individuals depends on the availability of healing resources that are generated by the healthy population. We find that epidemics spiral out of control into "explosive" spread if the cost of recovery is above a critical cost. This can occur even when the disease would die out without the resource constraint. The onset of explosive epidemics is very sudden, exhibiting a discontinuous transition under very general assumptions. We find analytical expressions for the critical cost and the size of the explosive jump in infection levels in terms of the parameters that characterize the spreading process. Our model and results apply beyond epidemics to contagion dynamics that self-induce constraints on recovery, thereby amplifying the spreading process.
description: 24 pages, 6 figures
Random Irregular Block-hierarchical Networks: Algorithms for Computation of Main Properties
Creators: name: Avetisyan, Svetlana
name: Samvelyan, Mikayel
name: Karapetyan, Martun
Publisher: name: arXiv
Year: 2015
Subjects: subject: Data Structures and Algorithms (cs.DS)
subject: FOS: Computer and information sciences

description: In this paper, the class of random irregular block-hierarchical networks is defined and algorithms for generation and calculation of network properties are described. The algorithms presented for this class of networks are more efficient than known algorithms both in computation time and memory usage and can be used to analyze topological properties of such networks. The algorithms are implemented in the system created by the authors for the study of topological and statistical properties of random networks.
description: The original is in Russian
Genes known to escape X chromosome inactivation predict co-morbid chronic musculoskeletal pain and posttraumatic stress symptom development in women following trauma exposure
Creators: name: Yu, Shan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: Co-morbid chronic musculoskeletal pain (CMSP) and posttraumatic stress symptoms (PTSS) are frequent sequelae of motor vehicle collision (MVC), are associated with greater disability than either outcome alone, and are more prevalent in women vs men. In the current study we assessed for evidence that gene transcripts originating from the X chromosome (XCh) contribute to sex differences in vulnerability to CMSP/PTSS after MVC. Nested samples were drawn from a longitudinal study of African American individuals, and CMSP (0-10 Numeric Rating Scale) and PTSS (Impact of Events Scale, Revised) outcomes were assessed six months following MVC. Blood RNA were sequenced (n=101) and the relationship between XCh mRNA expression levels and co-morbid CMSP/PTSS outcomes was evaluated using logistic regression analyses. A disproportionate number of peritraumatic XCh mRNA predicting CMSP/PTSS in women were genes previously found to escape XCh inactivation (XCI) (11/40, z=-2.9, p=0.004). Secondary analyses assessing gene ontology relationships between these genes identified an enrichment in genes known to influence neuronal plasticity. Further, the relationship of expression of two critical regulators of XCI, XIST and YY1, was different in women developing CMSP/PTSS. Together, these data suggest that XCh genes that escape inactivation may contribute to sex differences in vulnerability to CMSP/PTSS after MVC.
Supplemental Figures and Tables from Functional space expansion driven by transitions between energetically advantageous traits in the deep sea
Creators: name: Bryant, S. River D.
name: McClain, Craig R.
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Map of sampling sites, descriptions of functional trait categories, null model vs empirical unique trait combinations, correlation analysis, and post-hoc pairwise comparisons of functional niche energy regimes.
Euphorbia hypericifolia Linnaeus 1753
Creators: name: Mifsud, Stephen
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Malpighiales
Euphorbiaceae
Euphorbia
Euphorbia hypericifolia

description: Euphorbia hypericifolia Linnaeus (1753: 454) [Fig.1E]
 Origin: tropical and subtropical America (Steinmann et al. 2016, Tropicos 2017).
 Occurrences in Europe and the Mediterranean area: Aegean islands, Greece, Crete, Belgium (Raab-Straube & Raus 2015, Euro+Med 2006–2017), NE Sicily (Sciandrello et al. 2016) and Spain (Raab-Straube & Raus 2015).
Introduction in Malta: contaminated soil of imported plants or trees used to decorate roads, traffic islands, hotels and public spaces.
Habitat: Naturalised in soil for embellishment at roadsides and traffic islands, large planters, outdoor gardens and terraces. So far not observed on or beside curbs or paved ground.
Invasiveness: Weakly invasive, spread readily within the area it occurs but it is not able to disperse. Increased records during last three years are likely cases of new introductions. Not yet encountered in natural ecosystems, strictly urban species.
First record: The present record (Marsa, October 2009) is the first one for the Maltese islands.
Distribution: Scattered individuals in traffic islands (Manuel Dimech Street, Qormi), soil of embellished areas (e.g. il-Menqa, Marsa; Paradise Bay Hotel, Mellieħa) and large potted plants (Dragonara, St. Julians)
Flowering: June–December.
 Morphological observations: Suberect to erect habit with glabrous leaves and flowers. Leaflets variable in shape and of little diagnostic value, ranging from broadly ovate to narrow-lanceolate with a shallowly serrulate margin, usually lacking red markings. It is closely related to E. nutans Lagasca (1816: 17) and possibly confused with it locally, although the presence of both species in Malta is not excluded. E. hypericifolia differs from E. natans in having fruit up to 1.4 mm high and green (1.5–2.0 mm reddish or green in E. nutans); completely glabrous (slightly pubescent at the leaf nodes and base of stem in E. nutans) and usually some stipules are deltate and conspicuous (mostly vestigial or linear in E. nutans).
Chromosome number: 2n = 42 (Benedì & Orell 1992).
description: Published as part of Mifsud, Stephen, 2018, Contribution to the flora of the Maltese Islands: Euphorbia subg. Chamaesyce and Euphorbia exigua s. l. (Euphorbiaceae), pp. 153-166 in Phytotaxa 372 (2) on pages 159-160, DOI: 10.11646/phytotaxa.372.2.2, http://zenodo.org/record/13728780
Supplementary information from Protection from fishing improves body growth of an exploited species
Creators: name: Knutsen Sørdalen, Tonje
name: Halvorsen, Kim Tallaksen
name: Olsen, Esben Moland
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Additional results; figures (S1-S7) and tables (S1-S7)
Uniformity of the pseudomagnetic field in strained graphene
Creators: name: Verbiest, G. J.
name: Brinker, S.
name: Stampfer, C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We present a study on the uniformity of the pseudomagnetic field in graphene as a function of the relative orientation between the graphene lattice and straining directions. For this, we strained a regular micron-sized graphene hexagon by deforming it symmetrically by displacing three of its edges. By simulations, we found that the pseudomagnetic field is strongest if the strain is applied perpendicular to the armchair direction of graphene. For a hexagon with a side length of 1 ${\rm μ}$m, the pseudomagnetic field has a maximum of 1.2 T for an applied strain of 3.5% and it is uniform (variance $< 1$%) within a circle with a diameter of $\sim 520$ nm. This diameter is on the order of the typical diameter of the laser spot in a state-of-the-art confocal Raman spectroscopy setup, which suggests that observing the pseudomagnetic field in measurements of shifted magneto-phonon resonance is feasible.
description: 7 pages, 5 figures
title: Multi-agent Near Real-Time Simulation of Light Train Network Energy Sustainability Analysis
Creators: name: Guo, Yida
Publisher: name: University of Liverpool Repository
Year: 2021

description: As an attractive transportation mode, rail transit consumes a lot of energy while transporting a large number of passengers annually. Most energy-aimed research in rail transit focuses on optimizing the train timetable and speed trajectory offline. However, some disturbances during travel will cause the train to fail to follow the offline optimized control strategy, thus invalids the offline optimization. In the typical rail transit control framework, the moving authority of trains is calculated by the zone controller based on the moving/fixed block system in the zone. The zone controller is used to ensure safety when the travel plan of trains changes due to disturbance. Safety is guaranteed during the process, but the change of travel plan leads to extra energy costs. The energy-aimed optimization problem in rail transit requires ensuring safety, pursuing punctuality with considering track slope, travel comfort, energy transferring efficiency, and speed limit, etc. The complex constraints lead to high computational pressure. Therefore, it is difficult for the regional controller to re-optimize the travel plan for all affected trains in near real-time. Multi-agent systems are widely used in many other fields, which show decent performance in solving complex problems by coordinating multiple agents. This study proposes a multi-agent system with multiple optimization algorithms to realize energy-aimed re-optimization in rail transit under different disturbances. The system includes three types of agents, train agents, station agents and central agents. Each agent exchanges information by following the time trigger mechanism (periodically) and the event trigger mechanism (occasionally). Trigger mechanism ensures that affected agents receive necessary information when interference occurs, and their embedded algorithms can achieve necessary optimization. Four types of cases 5 / 128 are tested, and each case has plenty of scenarios. The tested results show that the proposed system provides encouraging performance on energy savings and computational speed.
Open Access Patterns in Emerging Scholars' Journal Choice: A Bibliometric Analysis
Creators: name: Argabright, Lynnee
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020
Subjects: Open access publishing
Communication in learning and scholarship
Content analysis (Communication)--Data processing
Bibliometrics
Information visualization

description: This bibliometric analysis of University of North Carolina at Chapel Hill research provides a case study for tenure-track faculty’s open access publishing action. Looking specifically at the publications of 300 tenure-track assistant professors and instructors, this study creates a series of quantitative information visualizations to see researcher publishing trends leading up to tenure review. It identifies the proportion of assistant professors publishing open access, breaks down the top departments, and shows how open access has increased over time. The study can inform efforts to provide services for tenure-track faculty and emerging scholars. Data from this study was collected through Scopus. Code and interactive visualizations are provided as supplemental files.
Anforderungen an die Orchestrierung modularer Prozessanlagen
Creators: name: Klose, Anselm
name: Merkelbach, Silke
name: Menschner, Anna
name: Hensel, Stephan
name: Heinze, Sebastian
name: Urbas, Leon
name: Bittorf, Lukas
name: Schäfer, Christian
name: Szmais, Stafanie
name: Eckert, Manfred
name: Rüde, Timo
name: Scherwietes, Thomas
name: Da Silva Santos, Polyana
name: Stenger, Frank
name: Holm, Thomas
name: Welscher, Wolfgang
name: Krink, Niclas
name: Schenk, Tim
name: Stutz, Andreas
name: Maurmaier, Mathias
name: Stark, Katharina
name: Hoernicke, Mario
name: Unland, Stefan
name: Erben, Stefan
name: Keßler, Franziska
name: Apitz, Frank
Publisher: name: Technische Universität Dresden
Year: 2019
Subjects: Information Technology
Engineering

description: Die Orchestrierung modularer Prozessanlagen beschreibt das Verschalten von modularen Prozesseinheiten (PEA) zu einer modularen Anlage, sowohl aus verfahrenstechnischer, als auch aus automatisierungstechnischer Sicht. In dem vorliegenden Bericht werden verschiedene Aspekte, welche durch die Modularisierung von Prozessanlagen entstehen addressiert und Anforderungen aufgestellt. Der Bericht ist aus mehreren Expertenworkshops im Rahmen des ENPRO2.0-Projektes ORCA (FKZ 03ET1517A-I) entstanden.
From measurements to inferences of physical quantities in numerical simulations
Creators: name: Nakamura, Tota
Publisher: name: arXiv
Year: 2015
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: We propose a change of style for numerical estimations of physical quantities from measurements to inferences. We estimate the most probable quantities for all the parameter region simultaneously by using the raw data cooperatively. Estimations with higher precisions are made possible. We can obtain a physical quantity as a continuous function, which is differentiated to obtain another quantity. We applied the method to the Heisenberg spin-glass model in three dimensions. A dynamic correlation-length scaling analysis suggests that the spin-glass and the chiral-glass transitions occur at the same temperature with a common exponent $ν$. The value is consistent with the experimental results. We found that a size-crossover effect explains a spin-chirality separation problem.
description: 5 pages, 5 figures, revised
From the cradle to the grave: child, infant and foetal burials in the Egyptian archaeological record from the Early Dynastic Period to the Middle Kingdom (ca. 3300-1650 BC)
Creators: name: Power, Ronika K.
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: This research investigates how current disciplinary perceptions of ancient Egyptian child, infant and foetal mortuary culture correspond with its actual nature and scope. It engages the fields of history, archaeology, physical anthropology and philosophy to present an inter-disciplinary investigation of child, infant and foetal burials in the Egyptian archaeological record. The research is based on a sample of 1,809 children, infants and foetuses derived from a survey of all available published archaeological data from the Egyptian Early Dynastic to Middle Kingdom Periods (ca. 3300—1650 BC), supplemented by unpublished Early Dynastic cemetery data from the Australian Centre for Egyptology’s Helwan Project. This thesis addresses the absence of child, infant and foetal mortuary culture in Egyptian archaeological research. To date, scholars have surmised that published cemetery data rarely include significant numbers of child, infant and foetal burials, thereby rendering them unavailable for study. This apparent absence is attributed to differential burial practices for these individuals, based on an assumption that at this young age, they were not considered embodied members of the community. However, these hypotheses have been formed without consultation of available historical, archaeological, and skeletal evidence. As a result, children are marginalised within Egyptian archaeological narratives. While many studies consider the position, value and agency of Egyptian children via their artistic and epigraphic representations, such methodologies confine children’s lived experiences within the conceptual boundaries of socialisation and familism. In this frame, they are denied the same ontological status as adults. Quantitative and qualitative data analyses delivered in this thesis recalibrate these perspectives of child, infant and foetal mortuary culture and revise their lived experiences and cultural capacities in Egyptian society. The identification of so many children in the archaeological record confirms their suitability as subjects of research. The observation of the majority of child, infant and foetal burials in communal cemetery contexts refute hypotheses of supposed differential mortuary treatment. Consistent observations of profound similarities between child and adult mortuary culture are found to be indicative of their ontological equity during the timeframes canvassed by this research. In contrast to current reconstructions of children as passive familial appendages, this research demonstrates that ancient Egyptian children, infants and foetuses were considered individual social entities with complete cultural capacities, and were actively engaged in extensive social networks between and amongst communities of both the living and the dead.
All Supplementary Materials from Female dewlap ornaments are evolutionarily labile and associated with increased diversification rates in Anolis lizards
Creators: name: Yuan, Michael L.
name: Westeen, Erin P.
name: Wogan, Guinevere O. U.
name: Wang, Ian J.
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences

description: All supplemental methods, results, discussion, tables, and figures provided as a single PDF.
PRISMA-P 2015 Checklist: Protocol for a systematic review and systems-based exploration of interventions to reduce medicines wastage
Creators: name: Harris, Áine
name: Jayesinghe, Ryan
name: Bonnici West, Lorna
name: Stewart, Derek
name: Grimes, Tamasine
name: Redmond, Patrick
Publisher: name: Zenodo
Year: 2023

description: PRISMA-P Checklist for Protocol for a systematic review and systems-based exploration of interventions to reduce medicines wastage.
Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross
Creators: name: West, Ande
name: Hampton, Brea K.
name: Noll, Kelsey E.
name: Ferris, Martin T.
name: Morrison, Thomas E.
name: McCarthy, Mary K.
name: de Villena, Fernando Pardo-Manuel
name: Morrison, Clayton R.
name: Kollmus, Heike
name: Whitmore, Alan C.
name: Heise, Mark T.
name: Schughart, Klaus
name: Mooney, Michael
name: Pilzner, Carolin
name: Leist, Sarah R.
name: Miller, Darla
name: Baric, Ralph S.
name: McWeeney, Shannon
name: Shaw, Ginger
name: Plante, Kenneth S.
name: Schaefer, Alexandra
name: Menachery, Vineet D.
name: Gralinski, Lisa E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Noll et al. use the Collaborative Cross, a mouse genetic reference population, to map genetic loci associated with variation in the humoral response to influenza virus infection. Cross-dataset comparison shows that mapped loci are important for antibody response to multiple pathogens, and candidate genes with likely translational relevance are identified. © 2020 The Author(s)Host genetic factors play a fundamental role in regulating humoral immunity to viral infection, including influenza A virus (IAV). Here, we utilize the Collaborative Cross (CC), a mouse genetic reference population, to study genetic regulation of variation in antibody response following IAV infection. CC mice show significant heritable variation in the magnitude, kinetics, and composition of IAV-specific antibody response. We map 23 genetic loci associated with this variation. Analysis of a subset of these loci finds that they broadly affect the antibody response to IAV as well as other viruses. Candidate genes are identified based on predicted variant consequences and haplotype-specific expression patterns, and several show overlap with genes identified in human mapping studies. These findings demonstrate that the host antibody response to IAV infection is under complex genetic control and highlight the utility of the CC in modeling and identifying genetic factors with translational relevance to human health and disease.
Pseudomonas aeruginosa LCT-PA220 Genome sequencing
Creators: name: BGI
Publisher: name: CNGB
Year: 2013
Subjects: Genome sequencing and assembly
Monoisolate

description: Pseudomonas aeruginosa is a ubiquitous, water-borne bacterium and opportunistic pathogen that caused respiratory and urinary tract infections in crew members of the Apollo missions during and/or immediately after space flight.
Serratia marcescens LCT-SM262 Genome sequencing
Creators: name: BGI
Publisher: name: CNGB
Year: 2013
Subjects: Genome sequencing and assembly
Monoisolate

description: Serratia marcescens is a species of motile, short rod-shaped, Gram-negative, facultative anaerobe bacterium. It is classified as an opportunistic pathogen that causes many nosocomial infections, such as sepsis, bacteremia, meningitis and so on. And it is resistant to many antibiotics. We will mainly study the virulence and the antibiotic-resistance of this species.
Serratia marcescens LCT-SM166 Genome sequencing
Creators: name: BGI
Publisher: name: CNGB
Year: 2013
Subjects: Genome sequencing and assembly
Monoisolate

description: Serratia marcescens is a species of motile, short rod-shaped, Gram-negative, facultative anaerobe bacterium. It is classified as an opportunistic pathogen that causes many nosocomial infections, such as sepsis, bacteremia, meningitis and so on. And it is resistant to many antibiotics. We will mainly study the virulence and the antibiotic-resistance of this species.
A tool for the assessment of the potential benefits of electric and hybrid cars for emissions reduction in urban areas
Creators: name: Zamboni, Giorgio
name: Dressino, Luca
name: Boileau, Hervé
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: A simulation tool was developed to evaluate variations in exhaust emissions from cars when replacing conventional powertrains with electric or hybrid propulsion systems. The model permits calculation of direct emissions (released at the vehicles’ exhaust) and indirect emissions (released when producing electricity for batteries recharging). To verify model outputs, a reference scenario was defined selecting the urban area of Genoa, Italy, considering the number of vehicles and mileage of eight vehicle categories. A simulated scenario was then designed, replacing cars belonging to older legally defined classes with electric and hybrid ones. Significant reductions were estimated for regulated pollutants, with higher benefits estimated for CO and NOX emissions, deriving from calculated reductions and contributions of cars in the reference scenario. No advantages were estimated for CO2, outlining that a change in the national mix for electricity production is also required.
Supplemental Information from Collective movement as a solution to noisy navigation and its vulnerability to population loss
Creators: name: Granger, Jesse
name: Johnsen, Sönke
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour
subject: Computational Biology

description: Many animals use the geomagnetic field to migrate long distances with high accuracy; however, research has shown that individual responses to magnetic cues can be highly variable. Thus, it has been hypothesized that magnetoreception alone is insufficient for accurate migrations and animals must either switch to a more accurate sensory cue or integrate their magnetic sense over time. Here we suggest that magnetoreceptive migrators could also use collective navigation strategies. Using agent-based models, we compare agents utilizing collective navigation to both the use of a secondary sensory system and time-integration. Our models demonstrate that collective navigation allows for 70% success rates for noisy navigators. To reach the same success rates, a secondary sensory system must provide perfect navigation for over 73% of the migratory route, and time integration must integrate over 50 time-steps, indicating that magnetoreceptive animals could benefit from using collective navigation. Finally, we explore the impact of population loss on animals relying on collective navigation. We show that as population density decreases, a greater proportion of individuals fail to reach their destination and that a 50% population reduction can result in up to a 37% decrease in the proportion of individuals completing their migration.
Src family kinase inhibitors block translation of alphavirus subgenomic mRNAs
Creators: name: Totonchy, Jennifer
name: Broeckel, Rebecca
name: Morrison, Thomas E.
name: Sarkar, Sanjay
name: Heise, Mark T.
name: Smith, Patricia
name: May, Nicholas A.
name: Kreklywich, Craig N.
name: Streblow, Daniel
name: Moorman, Nathaniel
name: Graves, Lee
name: DeFilippis, Victor R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2019

description: Alphaviruses are arthropod-transmitted RNA viruses that can cause arthralgia, myalgia, and encephalitis in humans. Since the role of cellular kinases in alphavirus replication is unknown, we profiled kinetic changes in host kinase abundance and phosphorylation following chikungunya virus (CHIKV) infection of fibroblasts. Based upon the results of this study, we treated CHIKV-infected cells with kinase inhibitors targeting the Src family kinase (SFK)–phosphatidylinositol 3-kinase (PI3K)–AKT–mTORC signaling pathways. Treatment of cells with SFK inhibitors blocked the replication of CHIKV as well as multiple other alphaviruses, including Mayaro virus, O’nyong-nyong virus, Ross River virus, and Venezuelan equine encephalitis virus. Dissecting the effect of SFK inhibition on alphavirus replication, we found that viral structural protein levels were significantly reduced, but synthesis of viral genomic and subgenomic RNAs was unaffected. By measuring the association of viral RNA with polyribosomes, we found that the SFK inhibitor dasatinib blocks alphavirus subgenomic RNA translation. Our results demonstrate a role for SFK signaling in alphavirus subgenomic RNA translation and replication. Targeting host factors involved in alphavirus replication represents an innovative, perhaps paradigm-shifting, strategy for exploring the replication of CHIKV and other alphaviruses while promoting antiviral therapeutic development.
The commutative core of a Leavitt path algebra
Creators: name: Canto, Cristóbal Gil
name: Nasr-Isfahani, Alireza
Publisher: name: arXiv
Year: 2015
Subjects: subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics

description: For any unital commutative ring $R$ and for any graph $E$, we identify the commutative core of the Leavitt path algebra of $E$ with coefficients in $R$, which is a maximal commutative subalgebra of the Leavitt path algebra. Furthermore, we are able to characterize injectivity of representations which gives a generalization of the Cuntz-Krieger uniqueness theorem.
description: 19 pages; revised version; to appear in Journal of Algebra
Mouse Models as Resources for Studying Infectious Diseases
Creators: name: Heise, Mark T.
name: Sarkar, Sanjay
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2019

description: Mouse models are important tools both for studying the pathogenesis of infectious diseases and for the preclinical evaluation of vaccines and therapies against a wide variety of human pathogens. The use of genetically defined inbred mouse strains, humanized mice, and gene knockout mice has allowed the research community to explore how pathogens cause disease, define the role of specific host genes in either controlling or promoting disease, and identify potential targets for the prevention or treatment of a wide range of infectious agents. This review discusses several of the most commonly used mouse model systems, as well as new resources such as the Collaborative Cross as models for studying infectious diseases.
Escherichia coli LCT-EC52 Genome sequencing
Creators: name: BGI
Publisher: name: CNGB
Year: 2013
Subjects: genome sequencing
Monoisolate

description: Escherichia coli (E. coli) is a motile, gram-negative and short bacillus with rounded ends and no spores, which is always employed as an important model organism in biological experiments due to its simple structure, rapid reproduction and easiness to be cultured.
Klebsiella pneumoniae CGMCC 1.1736 Genome sequencing
Creators: name: BGI
Publisher: name: CNGB
Year: 2013
Subjects: genome sequencing
Monoisolate

description: In 2011, Shenzhou 8 took the strain of K. pneumoniae to the outer space about 17 days. After the successful landing, cotrimoxazole resistance found in the strain.
Robust real time face recognition and tracking on gpu using fusion of rgb and depth image
Creators: name: Naik, Narmada
name: Rathna, G. N
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: This paper presents a real-time face recognition system using kinect sensor. The algorithm is implemented on GPU using opencl and significant speed improvements are observed. We use kinect depth image to increase the robustness and reduce computational cost of conventional LBP based face recognition. The main objective of this paper was to perform robust, high speed fusion based face recognition and tracking. The algorithm is mainly composed of three steps. First step is to detect all faces in the video using viola jones algorithm. The second step is online database generation using a tracking window on the face. A modified LBP feature vector is calculated using fusion information from depth and greyscale image on GPU. This feature vector is used to train a svm classifier. Third step involves recognition of multiple faces based on our modified feature vector.
Klebsiella pneumoniae CGMCC 1.1736 Genome sequencing
Creators: name: BGI
Publisher: name: CNGB
Year: 2013
Subjects: genome sequencing
Monoisolate

description: In 2011, Shenzhou 8 took the strain of K. pneumoniae to the outer space about 17 days. After the successful landing, the strain become hemolysis to the sheep blood agar culture plates.
American National Election Studies: 2020 Post-Election Survey
Creators: name: National Science Foundation (NSF)
Publisher: name: Roper Center for Public Opinion Research
Year: 2023

description: New content for the 2020 pre-election survey includes variables on sexual harassment and misconduct, health insurance, identity politics, immigration, media trust and misinformation, institutional legitimacy, campaigns, party images, trade tariffs and tax policy. New content for the 2020 post-election survey includes voting experiences, attitudes toward public health officials and organizations, anti-elitism, faith in experts/science, climate change, gun control, opioids, rural-urban identity, international trade, sexual harassment and MeToo, transgender military service, perception of foreign countries, group empathy, social media usage, misinformation, and personal experiences.