cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Synergistic inhibition of SARS-CoV-2 cell entry by otamixaban and covalent protease inhibitor
title: pre-clinical assessment of pharmacological and molecular properties
titleType: Subtitle
Creators: name: Hempel, Tim
name: Elez, Katarina
name: Krüger, Nadine
name: Raich, Lluís
name: Shrimp, Jonathan H.
name: Danov, Olga
name: Jonigk, Danny
name: Braun, Armin
name: Shen, Min
name: Hall, Matthew D.
name: Pöhlmann, Stefan
name: Hoffmann, Markus
name: Noe, Frank
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: SARS-CoV-2
subject: COVID-19 pandemic
subject: protease TMPRSS2
subject: cell entry
subject: otamixaban
subject: clinical assessment
subject: pharmacological properties
subject: molecular properties
subject: 500 Naturwissenschaften und Mathematik::530 Physik::539 Moderne Physik

description: SARS-CoV-2, the cause of the COVID-19 pandemic, exploits host cell proteins for viral entry into human lung cells. One of them, the protease TMPRSS2, is required to activate the viral spike protein (S). Even though two inhibitors, camostat and nafamostat, are known to inhibit TMPRSS2 and block cell entry of SARS-CoV-2, finding further potent therapeutic options is still an important task. In this study, we report that a late-stage drug candidate, otamixaban, inhibits SARS-CoV-2 cell entry. We show that otamixaban suppresses TMPRSS2 activity and SARS-CoV-2 infection of a human lung cell line, although with lower potency than camostat or nafamostat. In contrast, otamixaban inhibits SARS-CoV-2 infection of precision cut lung slices with the same potency as camostat. Furthermore, we report that otamixaban's potency can be significantly enhanced by (sub-) nanomolar nafamostat or camostat supplementation. Dominant molecular TMPRSS2-otamixaban interactions are assessed by extensive 109 μs of atomistic molecular dynamics simulations. Our findings suggest that combinations of otamixaban with supplemental camostat or nafamostat are a promising option for the treatment of COVID-19.
Ilhasina Krommelbein 1963
Creators: name: Bate, Raymond H.
name: Horne, David J.
name: Horne, Sarah E.
name: Douglas, Lyndsey
name: Miller, Giles
name: Lord, Alan R.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Cyprididae
Ilhasina

description: ILHASINA Krömmelbein, 1963
Type species: Ilhasina remanei Krömmelbein, 1963
Diagnosis: A genus of Cyprididae (? Cyclocypridinae) with the following peculiarities: carapace small (approx. 0.7mm to almost 1.0mm in length). Lateral outline approximately bean-shaped: anterior margin broadly rounded, posterior margin tapering more or less to a point. Dorsal margin equally curved or also distinctly angled; maximum height in the middle or just behind it. Marked or distinct coarse sculpture: extended or roundish swellings on the end-margins of both valves, or only on the posterior margins. Without fine sculpture. Internal features not known. Hinge presumably toothless.
description: Published as part of Bate, Raymond H., Horne, David J., Horne, Sarah E., Douglas, Lyndsey, Miller, Giles & Lord, Alan R., 2022, Non-marine Ostracoda (Crustacea) of the Early Cretaceous ' Pre-Salt' sediments of Brazil: An illustrated catalogue of the type specimens of Wicher, Krömmelbein, Krömmelbein & Weber, and Bate, pp. 1-84 in Zootaxa 5098 (1) on page 24, DOI: 10.11646/zootaxa.5098.1.1, http://zenodo.org/record/6036685
Validation of reference genes for expression analysis in a murine trauma model combining traumatic brain injury and femoral fracture
Creators: name: Otto, Ellen
name: Köhli, Paul
name: Appelt, Jessika
name: Menzel, Stefanie
name: Fuchs, Melanie
name: Bahn, Alina
name: Graef, Frank
name: Duda, Georg N.
name: Tsitsilonis, Serafeim
name: Keller, Johannes
name: Jahn, Denise
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Animals
subject: Brain Injuries, Traumatic
subject: Femoral Fractures
subject: Gene Expression Profiling
subject: Mice
subject: Mice, Inbred C57BL
subject: Organ Specificity
subject: Reference Standards
subject: Transcriptome
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Systemic and local posttraumatic responses are often monitored on mRNA expression level using quantitative real-time PCR (qRT-PCR), which requires normalisation to adjust for confounding sources of variability. Normalisation requests reference (housekeeping) genes stable throughout time and divergent experimental conditions in the tissue of interest, which are crucial for a reliable and reproducible gene expression analysis. Although previous animal studies analysed reference genes following isolated trauma, this multiple-trauma gene expression analysis provides a notable study analysing reference genes in primarily affected (i.e. bone/fracture callus and hypothalamus) and secondarily affected organs (i.e. white adipose tissue, liver, muscle and spleen), following experimental long bone fracture and traumatic brain injury. We considered tissue-specific and commonly used top-ranked reference candidates from different functional groups that were evaluated applying the established expression stability analysis tools NormFinder, GeNorm, BestKeeper and RefFinder. In conclusion, reference gene expression in primary organs is highly time point as well as tissue-specific, and therefore requires careful evaluation for qRT-PCR analysis. Furthermore, the general application of Ppia, particularly in combination with a second reference gene, is strongly recommended for the analysis of systemic effects in the case of indirect trauma affecting secondary organs through local and systemic pathophysiological responses.
Beckiella foveolata Balogh & Mahunka 1969
Creators: name: Revelo-Tobar, Harol
name: Ojeda, Margarita
name: García-Ayala, Leonardo J.
name: Palacios-Vargas, José G.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Sarcoptiformes
Dampfiellidae
Beckiella
Beckiella foveolata

description: Beckiella foveolata Balogh & Mahunka, 1969
 Distribution: Neotropical.
 Records in Mexico: Quintana Roo.
 Biogeographic province: Yucatan Peninsula.
 Habitat: Leaf litter and soil of medium sub evergreen forest, lowland forest, mangrove and halophyte vegetation.
 References: Vázquez et al. (2016): 147–162.
description: Published as part of Revelo-Tobar, Harol, Ojeda, Margarita, García-Ayala, Leonardo J. & Palacios-Vargas, José G., 2024, Checklist Of Oribatid Mites (Acari: Oribatida) From Mexico, pp. 1-178 in Zootaxa 5465 (1) on page 93, DOI: 10.11646/zootaxa.5465.1.1, http://zenodo.org/record/11613709
Changes in subclass-specific IgG Fc glycosylation associated with the postnatal maturation of the murine immune system
Creators: name: Barrientos, Gabriela
name: Habazin, Siniša
name: Novokmet, Mislav
name: Almousa, Yahia
name: Lauc, Gordan
name: Conrad, Melanie L.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Age Factors
subject: Animals
subject: Glycosylation
subject: Immune System
subject: Immunoglobulin Fc Fragments
subject: Immunoglobulin G
subject: Mice
subject: Mice, Inbred BALB C
subject: Pregnancy
subject: Spectrometry, Mass, Electrospray Ionization
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Early postnatal life is characterized by a critical time period in which the developing neonatal immune system transitions from passive immunity, induced by protective maternal antibodies, to the competence of a fully functioning immune system. The inflammatory capability of both maternal and neonatal antibodies is governed by N-linked glycosylation of the Fc region, and though this has been examined extensively in adults, there is currently little information regarding antibody glycosylation patterns during early postnatal life. To characterize the murine IgG Fc glycosylation profile during early life, we used nano-LC-ESI-Qq-TOF mass spectrometry analysis to assess subclass specific Asn-297 glycosylation patterns in the serum of BALB/c mice from 5–60 days of age. From birth to adulthood, we observed a decline in proinflammatory Fc glycosylation in all IgG subclasses. This was shown by significantly reduced agalactosylated and monogalactosylated structures combined with increased sialylation after weaning at 45 and 60 days of age. This information indicates that the transition between neonatal life and adulthood in mice is accompanied by reduction of inflammatory IgG antibodies. Our study contributes to a growing body of literature indicating the importance of IgG Fc glycosylation and its association with inflammation during different life stages.
The Way We Mourned
Creators: name: Qian, Gu
Publisher: name: Digital Repository at the University of Maryland
Year: 2016
Subjects: subject: Creative writing

description: The five short stories in this collection illustrate the insistence of the imagination in a foreign country. The protagonists deal with loss and exile of the human spirit, as well as language. In “View of the Taft Bridge”, a Chinese painter befriends a panda in the National Zoo in America’s capital. In “Early June before the Millennium”, an illicit student and teacher relationship unveils a painful history of the 1989 Tiananmen Square massacre. An adopted teenager finds her life unraveled at the presence of a new tenant who shares her ethnicity in “Girl in the Basement”. And the inertia of a housewife drives her desire to become a house cat, in “Catwoman”, until dream and reality become interchangeable. In “The Way We Mourned”, betrayal and memorial are closely knit in the wake of a close friend’s death. These stories search for connections to bridge “self” and “other”, as well as one’s present with a haunting past.
Supplementary document for Millimeter-scale ultrathin suspended metasurface integrated high finesse optomechanical cavity - 6031768.pdf
Creators: name: Jipeng, Xu
name: Liu, Ken
name: Sang, You
name: Tan, Zhongqi
name: Guo, Chucai
name: Hong, Zhu
Publisher: name: Optica Publishing Group
Year: 2022
Subjects: Optical Properties of Materials

description: supplemental 1_document
Tartuffe: Costume Design
Creators: name: Gunther, Tyler
Publisher: name: Digital Repository at the University of Maryland
Year: 2016
Subjects: subject: Theater
subject: Costume Design
subject: Tartuffe

description: The following thesis documents the design process and execution of Tyler Gunther’s costume design for the Theatre, Dance and Performance Studies’ production of Tartuffe. The production opened November 6, 2015 in the University of Maryland’s Kogod Theater. It was directed by Lee Mikeska Gardner with the set designed by Halea Coulter and lighting designed by Connor Dreibelbis.
“FOR THE UNION MAKES US STRONG”: PROTEST MUSIC IN THE 1989−90 PITTSTON STRIKE
Creators: name: Rogers, Alice Esther
Publisher: name: Digital Repository at the University of Maryland
Year: 2016
Subjects: subject: Music
subject: Social research
subject: Labor relations
subject: Inherent Audiences
subject: Labor Unions
subject: Pittston Strike
subject: Protest Music
subject: Union Songs
subject: United Mine Workers of America

description: Music making was a common practice during the 1989−90 strike against the Pittston Coal Company, an action led by the United Mine Workers of America. The types of music made varied greatly based on the contexts in which musicians and protesters were participating. In this thesis, I discuss how performers and audiences engaged with the music of the Pittston strike, with a focus on how different participatory and presentational contexts included music with similar or the same lyrics to achieve different goals. I argue that the musicians’ understanding of the people around them as potential participants, audiences, or inherent audiences shifted their use of music as they worked to use music strategically and effectively for the strike. The musical methods and considerations of the Pittston strike protesters have had a lasting impact on more recent protest movements.
ResearchBox 1265, 'Spend Time Save Money vs. Spend Money Save Time', https://researchbox.org/1265
Creators: name: Maria Giulia Trupia
name: Franklin Shaddy
Publisher: name: Zenodo
Year: 2024

description: Box title: 'Spend Time Save Money vs. Spend Money Save Time'   Reference: Trupia MG, Shaddy F. (2024) '"No time to buy": Asking consumers to spend time to save money is perceived as fairer than asking them to spend money to save time'. Journal of Consumer Psychology. . doi: 10.1002/jcpy.1444Note: this backup was created automatically by a ResearchBox bot
Beckiella lamellata Balogh & Mahunka 1969
Creators: name: Revelo-Tobar, Harol
name: Ojeda, Margarita
name: García-Ayala, Leonardo J.
name: Palacios-Vargas, José G.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Sarcoptiformes
Dampfiellidae
Beckiella
Beckiella lamellata

description: Beckiella lamellata Balogh & Mahunka, 1969.
 Distribution: Neotropical.
 Records in Mexico: Quintana Roo.
 Biogeographic province: Yucatan Peninsula.
 Habitat: Leaf litter and soil of medium sub evergreen forest, lowland forest, mangrove and halophyte vegetation. Low flooded rainforest soil.
 References: Vázquez (1999): 90–92; Hoffmann & López-Campos (2000): 155; Hoffmann & López-Campos (2002): 274; Vázquez et al. (2016): 147–162.
description: Published as part of Revelo-Tobar, Harol, Ojeda, Margarita, García-Ayala, Leonardo J. & Palacios-Vargas, José G., 2024, Checklist Of Oribatid Mites (Acari: Oribatida) From Mexico, pp. 1-178 in Zootaxa 5465 (1) on page 93, DOI: 10.11646/zootaxa.5465.1.1, http://zenodo.org/record/11613709
A broad diversity in oxygen affinity to haemoglobin
Creators: name: Balcerek, Björn
name: Steinach, Mathias
name: Lichti, Julia
name: Maggioni, Martina A.
name: Becker, Philipp N.
name: Labes, Robert
name: Gunga, Hanns-Christian
name: Persson, Pontus B.
name: Fähling, Michael
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Blood Gas Analysis
subject: Hemoglobins
subject: Hypoxia
subject: Oxygen Consumption
subject: Oxyhemoglobins
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Oxygen affinity to haemoglobin is indicated by the p50 value (pO2 at 50% O2Hb) and critically determines cellular oxygen availability. Although high Hb-O2 affinity can cause tissue hypoxia under conditions of well O2 saturated blood, individual differences in p50 are commonly not considered in clinical routine. Here, we investigated the diversity in Hb-O2 affinity in the context of physiological relevance. Oxyhaemoglobin dissociation curves (ODCs) of 60 volunteers (18–40 years, both sexes, either endurance trained or untrained) were measured at rest and after maximum exercise (VO2max) test. At rest, p50 values of all participants ranged over 7 mmHg. For comparison, right shift of ODC after VO2max test, representing the maximal physiological range to release oxygen to the tissue, indicated a p50 difference of up to 10 mmHg. P50 at rest differs significantly between women and men, with women showing lower Hb-O2 affinity that is determined by higher 2,3-BPG and BPGM levels. Regular endurance exercise did not alter baseline Hb-O2 affinity. Thus, p50 diversity is already high at baseline level and needs to be considered under conditions of impaired tissue oxygenation. For fast prediction of Hb-O2 affinity by blood gas analysis, only venous but not capillary blood samples can be recommended.
Leader Based Cyclic Pursuit
Creators: name: Miltenberger, Kenneth L.
Publisher: name: Digital Repository at the University of Maryland
Year: 2016
Subjects: subject: Electrical engineering
subject: Robotics
subject: Acoustics
subject: collective behavior
subject: cyclic pursuit
subject: leader based
subject: nonlinear control
subject: robot phonotaxis
subject: sound source localization

description: In this work a system of autonomous agents engaged in cyclic pursuit (under

constant bearing (CB) strategy) is considered, for which one informed agent (the

leader) also senses and responds to a stationary beacon. Building on the framework

proposed in a previous work on beacon-referenced cyclic pursuit, necessary and suffi-

cient conditions for the existence of circling equilibria in a system with one informed

agent are derived, with discussion of stability and performance. In a physical testbed,

the leader (robot) is equipped with a sound sensing apparatus composed of a

real time embedded system, estimating direction of arrival of sound by an Interaural

Level and Phase Difference Algorithm, using empirically determined phase and level

signatures, and breaking front-back ambiguity with appropriate sensor placement.

Furthermore a simple framework for implementing and evaluating the performance

of control laws with the Robot Operating System (ROS) is proposed, demonstrated,

and discussed.
Diagnostic performance of PI-RADS version 2.1 compared to version 2.0 for detection of peripheral and transition zone prostate cancer
Creators: name: Rudolph, Madhuri Monique
name: Baur, Alexander Daniel Jacques
name: Cash, Hannes
name: Haas, Matthias
name: Mahjoub, Samy
name: Hartenstein, Alexander
name: Hamm, Charlie Alexander
name: Beetz, Nick Lasse
name: Konietschke, Frank
name: Hamm, Bernd
name: Asbach, Patrick
name: Penzkofer, Tobias
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Area Under Curve
subject: Diffusion Magnetic Resonance Imaging
subject: Early Detection of Cancer
subject: Image-Guided Biopsy
subject: Neoplasm Grading
subject: Prostatic Neoplasms
subject: Radiographic Image Interpretation, Computer-Assisted
subject: Retrospective Studies
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The purpose of this study is to compare diagnostic performance of Prostate Imaging Reporting and Data System (PI-RADS) version (v) 2.1 and 2.0 for detection of Gleason Score (GS) ≥ 7 prostate cancer on MRI. Three experienced radiologists provided PI-RADS v2.0 scores and at least 12 months later v2.1 scores on lesions in 333 prostate MRI examinations acquired between 2012 and 2015. Diagnostic performance was assessed retrospectively by using MRI/transrectal ultrasound fusion biopsy and 10-core systematic biopsy as the reference. From a total of 359 lesions, GS ≥ 7 tumor was present in 135 lesions (37.60%). Area under the ROC curve (AUC) revealed slightly lower values for peripheral zone (PZ) and transition zone (TZ) scoring in v2.1, but these differences did not reach statistical significance. A significant number of score 2 lesions in the TZ were downgraded to score 1 in v2.1 showing 0% GS ≥ 7 tumor (0/11). The newly introduced diffusion-weighted imaging (DWI) upgrading rule in v2.1 was applied in 6 lesions from a total of 143 TZ lesions (4.2%). In summary, PI-RADS v2.1 showed no statistically significant differences in overall diagnostic performance of TZ and PZ scoring compared to v2.0. Downgraded BPH nodules showed favorable cancer frequencies. The new DWI upgrading rule for TZ lesions was applied in only few cases.
ResearchBox 1280, 'Data Colada (Miscellaneous)', https://researchbox.org/1280
Creators: name: Joseph Simmons
name: Uri Simonsohn
name: Leif Nelson
Publisher: name: Zenodo
Year: 2024

description: Box title: 'Data Colada (Miscellaneous)'   Reference: Uri Simonsohhn; Joe Simmons; Leif Nelson, '[107] Meaningless Means #3: The Truth About Lies', Data Coladahttps://datacolada.org/107Note: this backup was created automatically by a ResearchBox bot
The Relation between Substance Use and Medication Adherence among HIV Positive Substance Users in Residential Treatment
Creators: name: Hoffman, Elana Michelle
Publisher: name: Digital Repository at the University of Maryland
Year: 2015
Subjects: subject: Psychology
subject: FOS: Psychology
subject: Behavioral mediators
subject: HIV/AIDS
subject: Medication adherence
subject: Substance use

description: Poor medication adherence is problematic among HIV positive, low-income African-American substance users. Substance use has been shown to be associated with poor medication adherence, though we do not know the mechanism that underlies this relationship. Lack of positive environmental rewards and the propensity to discount delayed rewards may be possible mechanisms to explain this relationship. Using baseline data from a randomized controlled trial, we examined the relationships between substance use and medication adherence, testing both environmental rewards and delay discounting as independent mediators. There was a main effect of substance use on adherence, such that high frequency of substance use predicted poor adherence. There was also a main effect of environmental rewards on adherence, such that a lack of environmental reinforcement predicted poor adherence. This study shed light on the processes that contribute to low adherence, namely substance use and lack of environmental contingencies, and suggests important targets for intervention.
A communication partner training program: Assessing conversational behaviors and attitudes towards communication in Persons with Aphasia and their Communication Partners
Creators: name: Yutesler, Allison E. Carlson
Publisher: name: Digital Repository at the University of Maryland
Year: 2016
Subjects: subject: Speech therapy
subject: Aphasia
subject: Communication partner
subject: conversational behaviors
subject: Conversation training

description: This study examined the conversational behaviors of eleven dyads consisting of a person with aphasia (PWA) and their familiar communication partner (CP), and investigated changes in behaviors as a result of attending a communication partner-training program CPT). Attitudes about communication were examined and related to conversational behaviors observed pre- and post- training. Results indicated that CPs and PWA used significantly more facilitating behaviors than barrier behaviors, although most dyads experienced some barriers. A comparison of pre-and post-CPT conversations revealed a significant interaction between time and type of behavior, with the increase in the number of facilitators approaching significance. Overall, persons with aphasia and their conversational partners expressed positive attitudes about communication. There were no significant correlations between scores on attitude surveys and behaviors pre or post-training. This study demonstrated that these dyads employed facilitative conversational behaviors even before CPT, and that facilitative behaviors can increase after a one-day training workshop.
EFFECT OF COMPOST ON THE MICROCLOVER ESTABLISHMENT AND USE OF COMPOST AND MICROCLOVER TO REDUCE LAWN NUTRIENT RUNOFF
Creators: name: Xiao, Xiayun
Publisher: name: Digital Repository at the University of Maryland
Year: 2016
Subjects: subject: Agriculture
subject: compost
subject: microclover
subject: runoff
subject: straw
subject: tall fescue
subject: turfgrass

description: High volume compost incorporation can reduce runoff from compacted soils but its use also associated with elevated N and P concentrations in runoff making it difficult to assess if this practice will reduce nutrient loading of surface waters. Additionally, little is known about how this practice will effect leguminous species establishment in lawns as means to reduce long term fertilizer use. When 5 cm of compost was incorporated into soil a reduction in runoff of 40 and 59% was needed for N and P losses from a tall fescue + microclover lawn to be equivalent to a non-compost amended soil supporting a well fertilized tall fescue lawn.  Use of compost as a soil amendment resulted in quicker lawn establishment and darker color, when compared to non-amended soil receiving a mineral fertilizer. Biosolid composts containing high amounts ammonium severely reduce the establishment of clover in tall fescue + micrclover seed mixture.
Ilhasina remanei Krommelbein 1963
Creators: name: Bate, Raymond H.
name: Horne, David J.
name: Horne, Sarah E.
name: Douglas, Lyndsey
name: Miller, Giles
name: Lord, Alan R.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Cyprididae
Ilhasina
Ilhasina remanei

description: Ilhasina remanei Krömmelbein, 1963
Diagnosis: A species of the genus Ilhasina n. g. with a very small carapace (approx. 0.7 to 0.8mm in length). Carapace in lateral outline more or less bean-shaped. Maximum carapace height just behind the carapace centre. In dorsal view the carapace is wedge-shaped, flanks slightly indented in front of the centre. Maximum carapace width is approximately two thirds of the carapace length. Posterior margin of both valves with a node-like or more extended swelling of variably strong definition; more seldom a similar yet always much weaker swelling on the anterior margin of the right valve.
description: Published as part of Bate, Raymond H., Horne, David J., Horne, Sarah E., Douglas, Lyndsey, Miller, Giles & Lord, Alan R., 2022, Non-marine Ostracoda (Crustacea) of the Early Cretaceous ' Pre-Salt' sediments of Brazil: An illustrated catalogue of the type specimens of Wicher, Krömmelbein, Krömmelbein & Weber, and Bate, pp. 1-84 in Zootaxa 5098 (1) on page 24, DOI: 10.11646/zootaxa.5098.1.1, http://zenodo.org/record/6036685
Happy and Other Stories
Creators: name: Perel, Blaire
Publisher: name: Digital Repository at the University of Maryland
Year: 2016
Subjects: subject: Creative writing

description: The characters in “Happy,” “The Price of Independence,” “Itch,” and “Guillotine” all struggle with their loss of power and ability to successfully navigate their own lives. Though different genders, ages, and worlds are rendered each character must choose to either face their conflict head on or submit to the external pressure present. “The Price of Independence” and “Itch” highlight the precariousness of relationships and how one relationship, whether it be romantic or platonic, can change everything. “Happy” and “Guillotine” feature characters struggling from within, they are separated from the world around them and their failures force a spotlight on the misconceptions of mental health care.
Calix[4]pyrrolato Aluminate Catalyzes the Dehydrocoupling of Phenylphosphine Borane to High Molar Weight Polymers
Creators: name: Schön, Florian
name: Sigmund, Lukas M.
name: Schneider, Friederike
name: Hartmann, Deborah
name: Wiebe, Matthew A.
name: Manners, Ian
name: Greb, Lutz
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: Aluminum
subject: Dehydropolymerization
subject: Metal–Ligand Cooperativity
subject: Polymers
subject: Polyphosphinoboranes
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

description: High molar weight polyphosphinoboranes represent materials with auspicious properties, but their preparation requires transition metal-based catalysts. Here, calix[4]pyrrolato aluminate is shown to induce the dehydropolymerization of phosphine boranes to high molar mass polyphosphinoboranes (up to Mn=43 000 Da). Combined GPC and 31P DOSY NMR spectroscopic analyses, quantum chemical computations, and stoichiometric reactions disclose a P−H bond activation by the cooperative action of the square-planar aluminate and the electron-rich ligand framework. This first transition metal-free catalyst for P−B dehydrocoupling overcomes the problem of residual d-block metal impurities in the resulting polymers that might interfere with the reproducibility of the properties for this emerging class of inorganic materials.
INTIMATE APPAREL: AN EXPLORATION OF COSTUME DESIGN IDEAS AND PROCESS FOR THE UNIVERSITY OF MARYLAND’S DEPARTMENT OF THEATRE, DANCE AND PERFORMING 2015 PRODUCTION
Creators: name: Rodgers, Marchlena
Publisher: name: Digital Repository at the University of Maryland
Year: 2016
Subjects: subject: Theater

description: The following thesis navigates the primary artistic concept, design process and execution of Marchlena Rodgers’ costume design for the University of Maryland’s production of Intimate Apparel. Intimate Apparel opened October 9, 2015 in the University of Maryland’s Kay Theatre. The piece was written by Lynn Nottage directed by Jennifer Nelson. The set was designed by Lydia Francis, Lighting was designed by Max Doolittle.
Gate-opening induced by C8 aromatics in a double diamondoid coordination network
Creators: name: Koupepidou, Kyriaki
name: Wang, Shi-Qiang
name: Nikolayenko, Varvara Igorivna
name: Castell, Dominic
name: Matos, Catiúcia
name: Vandichel, Matthias
name: Zaworotko, Michael
Publisher: name: University of Limerick
Year: 2024
Subjects: classificationCode: 34
subject: Chemical sciences
subject: FOS: Chemical sciences

description: Coordination networks (CNs) that undergo guest-induced structural transformations are of topical interest thanks to their potential utility in separations and storage applications. Herein, we report a double diamondoid (ddi) topology CN, [Ni2(bimpz)2(bdc)2(H2O)]n or X-ddi-2-Ni (H2bdc = 1,4-benzenedicarboxylic acid, bimpz = 3,6-bis(imidazol-1-yl)pyridazine), that undergoes structural transformations induced by C8 isomers, i.e., xylenes (o-xylene, OX; m-xylene, MX; p-xylene, PX) and ethylbenzene (EB). X-ddi-2-Ni was characterized by single-crystal to single-crystal transformations from a nonporous phase, X-ddi-2-Ni-β, to isostructural C8-loaded phases, namely X-ddi-2-Ni-OX, X-ddi-2-Ni-MX, X-ddi-2-Ni-PX and X-ddi-2-Ni-EB. X-ddi-2-Ni accommodates two C8 isomers per Ni unit, resulting in relatively high uptake (ca. 50 wt %), but with low selectivity toward C8 isomers as found using nuclear magnetic resonance (NMR) and gas chromatography (GC). In addition, a narrow range of gate-opening pressures for each isomer was determined from dynamic vapor sorption, consistent with the nonadaptable nature of the C8-loaded phase determined crystallographically, also supported by modeling.
Non-thermal effects of radiofrequency electromagnetic fields
Creators: name: Wust, Peter
name: Kortüm, Benedikt
name: Strauss, Ulf
name: Nadobny, Jacek
name: Zschaeck, Sebastian
name: Beck, Marcus
name: Stein, Ulrike
name: Ghadjar, Pirus
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: radiofrequency electromagnetic fields
subject: cancer cell lines
subject: non-thermal effects
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: We explored the non-thermal effects of radiofrequency (RF) electromagnetic fields and established a theoretical framework to elucidate their electrophysiological mechanisms. In experiments, we used a preclinical treatment device to treat the human colon cancer cell lines HT-29 and SW480 with either water bath heating (WB-HT) or 13.56 MHz RF hyperthermia (RF-HT) at 42 degrees C for 60 min and analyzed the proliferation and clonogenicity. We elaborated an electrical model for cell membranes and ion channels and estimated the resulting ion fluxes. The results showed that, for both cell lines, using RF-HT significantly reduced proliferation and clonogenicity compared to WB-HT. According to our model, the RF electric field component was rectified and smoothed in the direction of the channel, which resulted in a DC voltage of similar to 1 mu V. This may induce ion fluxes that can potentially cause relevant disequilibrium of most ions. Therefore, RF-HT creates additional non-thermal effects in association with significant ion fluxes. Increasing the understanding of these effects can help improve cancer therapy.
Ilhasina remanei subsp. remanei Krommelbein 1963
Creators: name: Bate, Raymond H.
name: Horne, David J.
name: Horne, Sarah E.
name: Douglas, Lyndsey
name: Miller, Giles
name: Lord, Alan R.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Cyprididae
Ilhasina
Ilhasina remanei
Ilhasina remanei remanei krömmelbein, 1963

description: Ilhasina remanei remanei Krömmelbein, 1963
Fig. 5, 8a–c
1963 Ilhasina remanei remanei n. ssp. —Krömmelbein, p. 378, 380, pl. 1, fig. 1.
Diagnosis: The nominate subspecies of Ilhasina remanei with the following peculiarities: thickening on the posterior end of both valves rather variable in its strength, of a more or less elongated shape, always lying very close to the posterior margin. More seldom a similar, but much weaker swelling on the anterior margin of the right valve.
Holotype: Carapace, SMF Xe 4650.
Paratypes: 3 carapaces, SMF Xe 4651.
Dimensions: Holotype, length 0.76mm, height 0.45mm, width 0.34mm.
description: Published as part of Bate, Raymond H., Horne, David J., Horne, Sarah E., Douglas, Lyndsey, Miller, Giles & Lord, Alan R., 2022, Non-marine Ostracoda (Crustacea) of the Early Cretaceous ' Pre-Salt' sediments of Brazil: An illustrated catalogue of the type specimens of Wicher, Krömmelbein, Krömmelbein & Weber, and Bate, pp. 1-84 in Zootaxa 5098 (1) on page 24, DOI: 10.11646/zootaxa.5098.1.1, http://zenodo.org/record/6036685
Multiplex enzyme activity imaging by MALDI-IMS of substrate library conversions
Creators: name: Klein, Oliver
name: Haeckel, Akvile
name: Reimer, Ulf
name: Nebrich, Grit
name: Schellenberger, Eyk
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Animals
subject: Enzymes
subject: Molecular Imaging
subject: Peptides
subject: Protein Interaction Mapping
subject: Small Molecule Libraries
subject: Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Enzymes are fundamental to biological processes and involved in most pathologies. Here we demonstrate the concept of simultaneously mapping multiple enzyme activities (EA) by applying enzyme substrate libraries to tissue sections and analyzing their conversion by matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS). To that end, we spray-applied a solution of 20 naturally derived peptides that are known substrates for proteases, kinases, and phosphatases to zinc-fixed paraffin tissue sections of mouse kidneys. After enzyme conversion for 5 to 120 min at 37 °C and matrix application, the tissue sections were imaged by MALDI-IMS. We could image incubation time-dependently 16 of the applied substrates with differing signal intensities and 12 masses of expected products. Utilizing inherent enzyme amplification, EA-IMS can become a powerful tool to locally study multiple, potentially even lowly expressed, enzyme activities, networks, and their pharmaceutical modulation. Differences in the substrate detectability highlight the need for future optimizations.
An Investigation of Child and Adolescent Dental Sealant Predictors, NHANES 2011-2012
Creators: name: Roman, Agnieszka Anna
Publisher: name: Digital Repository at the University of Maryland
Year: 2016
Subjects: subject: Epidemiology
subject: Dentistry
subject: FOS: Clinical medicine
subject: Public health
subject: caries
subject: dental
subject: disparities
subject: prevention
subject: sealants

description: Objective: To examine sociodemographic and dental factors for associations with dental sealant placement in children and adolescents aged 6-18 years old.

Methods: Secondary data analysis of 2011-2012 NHANES data was conducted. Multiple logistic regression models were used to assess relationships between predictor variables and sealant presence.

Results: More than a third (37.1%) of children and adolescents have at least one sealant present; 67.9% of children compared with 40.4% of adolescents. Racial/ethnic differences exist, with Non-Hispanic black youth having the lowest odds of having sealants. Sealant placement odds vary by presence of dental home; the magnitude of the odds varies by age group. Those with untreated decay have lower odds of having sealants than those who do not have untreated decay (child OR: 2.6, 95% CI: 1.83-3.72; adolescent OR: 3.9, 95% CI: 2.59-6.07).

Conclusion: Disparities exist in odds of sealant prevalence across racial/ethnic groups, income levels, and dental disease and visit characteristics. Further research is necessary to understand the reasons for these differences and to inform future interventions.
White Moths
Creators: name: Kerr, Kelsey Ann
Publisher: name: Digital Repository at the University of Maryland
Year: 2016
Subjects: subject: Creative writing
subject: Grief
subject: Love
subject: Poetry

description: This collection navigates the process of grief after the speaker’s loss of both parents. The speaker struggles to connect with both the dead and the living through her physical intimacy and relationship with a troubled lover. These poems explore and exhume the speaker’s buried memories, moving from moments of wry humor to meaningful and sometimes painful discovery. Ultimately, these poems attempt to reach beyond the self, to transform loss and loneliness from a human condition into a musical tool of art for human connection.
Ilhasina remanei subsp. cuneiformis Krommelbein 1963
Creators: name: Bate, Raymond H.
name: Horne, David J.
name: Horne, Sarah E.
name: Douglas, Lyndsey
name: Miller, Giles
name: Lord, Alan R.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Cyprididae
Ilhasina
Ilhasina remanei
Ilhasina remanei cuneiformis krömmelbein, 1963

description: Ilhasina remanei cuneiformis Krömmelbein, 1963
Fig. 5, 9a–c
1963 Ilhasina remanei cuneiformis n. ssp. —Krömmelbein, p. 381–382, pl. 1, fig. 2.
Diagnosis: A subspecies of Ilhasina remanei n. g. n. sp. with a carapace which, in dorsal view, runs in a wedge shape towards the front and with a thick, node-shaped swelling on the posterior field of each valve. In contrast to I. remanei remanei n. sp. n. ssp. the swelling has a roundish outline (not elongated) and lies further away from the posterior margin of the valves.
Holotype: Carapace, SMF Xe 4652.
Paratypes: 2 carapaces, SMF Xe 4653.
Dimensions: Holotype, length 0.71mm, height 0.40mm, width 0.40mm.
description: Published as part of Bate, Raymond H., Horne, David J., Horne, Sarah E., Douglas, Lyndsey, Miller, Giles & Lord, Alan R., 2022, Non-marine Ostracoda (Crustacea) of the Early Cretaceous ' Pre-Salt' sediments of Brazil: An illustrated catalogue of the type specimens of Wicher, Krömmelbein, Krömmelbein & Weber, and Bate, pp. 1-84 in Zootaxa 5098 (1) on pages 24-25, DOI: 10.11646/zootaxa.5098.1.1, http://zenodo.org/record/6036685
In vivo non-invasive staining-free visualization of dermal mast cells in healthy, allergy and mastocytosis humans using two-photon fluorescence lifetime imaging
Creators: name: Kröger, Marius
name: Scheffel, Jörg
name: Nikolaev, Viktor V.
name: Shirshin, Evgeny A.
name: Siebenhaar, Frank
name: Schleusener, Johannes
name: Lademann, Jürgen
name: Maurer, Marcus
name: Darvin, Maxim E.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Case-Control Studies
subject: Dermatitis, Atopic
subject: Fluorescence
subject: Hypersensitivity
subject: Mastocytosis
subject: Microscopy, Fluorescence, Multiphoton
subject: Optical Imaging
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Mast cells (MCs) are multifunctional cells of the immune system and are found in skin and all major tissues of the body. They contribute to the pathology of several diseases including urticaria, psoriasis, atopic dermatitis and mastocytosis where they are increased at lesional sites. Histomorphometric analysis of skin biopsies serves as a routine method for the assessment of MC numbers and their activation status, which comes with major limitations. As of now, non-invasive techniques to study MCs in vivo are not available. Here, we describe a label-free imaging technique to visualize MCs and their activation status in the human papillary dermis in vivo. This technique uses two-photon excited fluorescence lifetime imaging (TPE-FLIM) signatures, which are different for MCs and other dermal components. TPE-FLIM allows for the visualization and quantification of dermal MCs in healthy subjects and patients with skin diseases. Moreover, TPE-FLIM can differentiate between two MC populations in the papillary dermis in vivo—resting and activated MCs with a sensitivity of 0.81 and 0.87 and a specificity of 0.85 and 0.84, respectively. Results obtained on healthy volunteers and allergy and mastocytosis patients indicate the existence of other MC subpopulations within known resting and activated MC populations. The developed method may become an important tool for non-invasive in vivo diagnostics and therapy control in dermatology and immunology, which will help to better understand pathomechanisms involving MC accumulation, activation and degranulation and to characterize the effects of therapies that target MCs.
Quantifying the impacts of urban wind sheltering on the building energy consumption
Creators: name: Khoshdel Nikkho, Saber
Publisher: name: Digital Repository at the University of Maryland
Year: 2016
Subjects: subject: Mechanical engineering
subject: FOS: Mechanical engineering
subject: Building energy simulations
subject: Computational Fluid Dynamics
subject: Local wind flow
subject: Neighborhood effects
subject: Urban microclimate

description: Common building energy modeling approaches do not account for the influence of surrounding neighborhood on the energy consumption patterns. This thesis develops a framework to quantify the neighborhood impact on a building energy consumption based on the local wind flow. The airflow in the neighborhood is predicted using Computational Fluid Dynamics (CFD) in eight principal wind directions. The developed framework in this study benefits from wind multipliers to adjust the wind velocity encountering the target building. The input weather data transfers the adjusted wind velocities to the building energy model. In a case study, the CFD method is validated by comparing with on-site temperature measurements, and the building energy model is calibrated using utilities data. A comparison between using the adjusted and original weather data shows that the building energy consumption and air system heat gain decreased by 5% and 37%, respectively, while the cooling gain increased by 4% annually.
Ilhasina torosa Krommelbein 1963
Creators: name: Bate, Raymond H.
name: Horne, David J.
name: Horne, Sarah E.
name: Douglas, Lyndsey
name: Miller, Giles
name: Lord, Alan R.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Cyprididae
Ilhasina
Ilhasina torosa

description: Ilhasina torosa Krömmelbein, 1963
Fig. 5, 10a–c
1963 Ilhasina torosa n. sp. —Krömmelbein, p. 382–383, pl. 1, fig. 3.
Diagnosis: So far the largest Ilhasina species (around 0.9mm carapace length) with a stocky carapace shape, highly arched dorsal margin, and posteriorly very strongly widened carapace (dorsal view!). On the posterior field of both valves is a strong callus, which runs diagonally from the upper anterior to the lower posterior, which towards the posterior at the top is placed distinctly concavely against the valve arch. A similar more rounded and significantly weaker thickening occasionally on the anterior margin of the right valve.
Holotype: Carapace, SMF Xe 4654.
Paratypes: 3 carapaces, SMF Xe 4655.
Dimensions: Holotype, length 0.89mm, height 0.54mm, width 0.54mm.
Remark (Bate et al. herein): Catalogue number for paratypes incorrect in original paper.
description: Published as part of Bate, Raymond H., Horne, David J., Horne, Sarah E., Douglas, Lyndsey, Miller, Giles & Lord, Alan R., 2022, Non-marine Ostracoda (Crustacea) of the Early Cretaceous ' Pre-Salt' sediments of Brazil: An illustrated catalogue of the type specimens of Wicher, Krömmelbein, Krömmelbein & Weber, and Bate, pp. 1-84 in Zootaxa 5098 (1) on page 25, DOI: 10.11646/zootaxa.5098.1.1, http://zenodo.org/record/6036685
Automatic prostate and prostate zones segmentation of magnetic resonance images using DenseNet-like U-net
Creators: name: Aldoj, Nader
name: Biavati, Federico
name: Michallek, Florian
name: Stober, Sebastian
name: Dewey, Marc
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Algorithms
subject: Image Interpretation, Computer-Assisted
subject: Magnetic Resonance Imaging
subject: Prostate
subject: Prostatic Neoplasms
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Magnetic resonance imaging (MRI) provides detailed anatomical images of the prostate and its zones. It has a crucial role for many diagnostic applications. Automatic segmentation such as that of the prostate and prostate zones from MR images facilitates many diagnostic and therapeutic applications. However, the lack of a clear prostate boundary, prostate tissue heterogeneity, and the wide interindividual variety of prostate shapes make this a very challenging task. To address this problem, we propose a new neural network to automatically segment the prostate and its zones. We term this algorithm Dense U-net as it is inspired by the two existing state-of-the-art tools—DenseNet and U-net. We trained the algorithm on 141 patient datasets and tested it on 47 patient datasets using axial T2-weighted images in a four-fold cross-validation fashion. The networks were trained and tested on weakly and accurately annotated masks separately to test the hypothesis that the network can learn even when the labels are not accurate. The network successfully detects the prostate region and segments the gland and its zones. Compared with U-net, the second version of our algorithm, Dense-2 U-net, achieved an average Dice score for the whole prostate of 92.1± 0.8% vs. 90.7 ± 2%, for the central zone of 89.5±2% vs. 89.1±2.2 %, and for the peripheral zone of 78.1± 2.5% vs. 75±3%. Our initial results show Dense-2 U-net to be more accurate than state-of-the-art U-net for automatic segmentation of the prostate and prostate zones.
title: La Broye :
title: La Bressonne et la Mérine et leurs falaises de Molasse, le 20 juin 2020
titleType: Subtitle
title: La Broye :
titleType: AlternativeTitle
Creators: name: Magnin-Gonze, Joëlle
Publisher: name: Unknown
Year: 2021

description: L’excursion proposée ce 20 juin 2020 a pour buts, d’une part de découvrir dans les falaises et sur les terrasses alluviales bordant la Bressonne une flore montagnarde inattendue à si basse altitude et, d’autre part, d’observer sur les berges de la Mérine une quinzaine d’espèces de fougères. Pour ce faire, nous sommes contraints de descendre dans le lit de la Bressonne et de le parcourir sur plusieurs centaines de mètres, une expérience qu’on ne fait que rarement dans un pays où la plupart des cours d’eau sont bordés de chemins pédestres ou de sentiers d’accès pour les pêcheurs.
Hauntings
Creators: name: Smith, Julia G.
Publisher: name: Digital Repository at the University of Maryland
Year: 2016
Subjects: subject: Dance
subject: Theater
subject: dance theater

description: The thesis paper is about the process of creating and directing Hauntings, a dance theater work, performed in the 2016 MFA Spring Thesis Concert. The concert was shared with Curtis Stedge, fellow cohort and MFA candidate in the Department of Theater, Dance and Performance Studies at the University of Maryland, College Park.  This document is meant to accompany the archival footage of the dance. Hauntings is a moving lyric poem depicting themes and motifs of the emotional landscape of its characters. It is a time-less world rendering the complexities of the psyche and soul.  Love, obsession, loss, and nostalgia emerge as Smith and her fellow artists represent characters struggling with impermanence and mortality. The work is seeped in symbolism and metaphor.  The dances/scenes draw inspiration from the music of Chopin, Liszt, Stravinsky, Charles Trenet, Rina Ketty, and poetry by John Keats, Sylvia Plath, Ted Hughes, W.B Yeats, and Claire Clemons Cowan.