cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
ผลของหลักสูตรการสอนโรคหนอนพยาธิ ต่อพฤติกรรมการป้องกันโรคและความชุกของโรคพยาธิไส้เดือนในนักเรียนโรงเรียนตำรวจตระเวนชายแดนหม่อมราชวงศ์เฉลิมลักษณ์ จันทรเสน ปี 2561
Creators: name: กู้เกียรติ ก้อนแก้ว
Publisher: name: กองนวัตกรรมและวิจัย กรมควบคุมโรค
Year: 2563
Subjects: หลักสูตรการสอนโรคหนอนพยาธิ
พยาธิไส้เดือน
พฤติกรรมการป้องกันโรค

description: วารสารควบคุมโรค, 46, 1, 65-74
title: 01_0995
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Nachhaltige Entwicklung in der Schweizer Landwirtschaft. Sichtweisen von Lernenden des Berufs Landwirt / Landwirtin
Creators: name: Krummen, Michaela
Publisher: name: Eidgenössische Hochschule für Berufsbildung EHB
Year: 2024
Subjects: MSc Thesis
Berufliche Grundbildung
Landwirtschaft
Nachhaltige Entwicklung
Nachhaltigkeitsverständnis
Nachhaltigkeitsbewusstsein
Berufsbildung für Nachhaltige Entwicklung

description: Nachhaltige Entwicklung (NE) ist ein vielschichtiges und kontrovers diskutiertes Leitbild, das ökologische Verantwortung, soziale Solidarität und wirtschaftliche Leistungsfähigkeit vereint. Der Berufsbildung und den Lernenden als zukünftigen Akteuren kommt bei der nachhaltigen Transformation eine zentrale Rolle zu, da ein wesentlicher Teil der Ressourcen(-über)-nutzung in der Arbeitswelt stattfindet. Diese qualitative Studie untersucht, wie angehende Landwirt*in-nen NE mit Blick auf ihren Beruf verstehen und wie sich ihr Nachhaltigkeitsbewusstsein gestaltet. Dazu wurden an drei landwirtschaftlichen Berufsschulen in der Schweiz Fokusgruppendiskussionen durchgeführt und die Daten mittels qualitativer Inhaltsanalyse ausgewertet. Die Ergebnisse zeigen, dass die Lernenden über ein breites Wissen zu NE verfügen. Sie beschreiben die vielfältigen Beiträge der Landwirtschaft zu einer NE, wie die standortangepasste Produktion und die Förderung der Biodiversität. Dennoch bleibt ihr Verständnis lückenhaft, insbesondere in Bezug auf globale Zusammenhänge und die Rolle des Ernährungssystems für die Erreichung der globalen Nachhaltigkeitsziele. Deutlich wird auch die ambivalente Haltung der Lernenden zum Thema NE. Sie nehmen die Schweizer Landwirtschaft als bereits sehr nachhaltig wahr und sehen wenig Handlungsbedarf. Herausforderungen wie Bodenverlust, Nährstoffverluste, Treibhausgasemissionen oder Food Waste werden unterschätzt. Hauptsorgen sind der hohe wirtschaftliche Druck und die unsicheren Perspektiven. Mit NE verbinden die Lernenden eine Extensivierung der Produktion und steigende Kosten, was die aus ihrer Sicht wichtigste Aufgabe der Landwirtschaft, die Versorgung der Schweizer Bevölkerung mit Nahrungsmitteln, gefährdet. Die Forschungsarbeit liefert Impulse für die berufliche Grundbildung: Um ein umfassenderes Verständnis und das Bewusstsein für NE zu fördern, sollten gezielt Themen integriert werden, die insbesondere auch die Potentiale und Chancen einer nachhaltigen Transformation für die Landwirtschaft aufzeigen.
Towards a Framework for Assessing the Impact of Cadastral Development on Land Rights-Holders
Creators: name: Hull, Simon
name: Whittal, Jennifer
Publisher: name: figshare
Year: 2016
Subjects: subject: 90999 Geomatic Engineering not elsewhere classified
subject: FOS: Environmental engineering

description: Although there is a published lack of accepted frameworks and methodologies for the comparison and evaluation of national land administration systems, several frameworks for assessing the performance of LAS in terms of different aspects of these systems have been proposed. The bulk are biased towards analysis of technical, institutional, or cost/benefit aspects, or focus on economic efficiency and effectiveness. There is a dearth of frameworks for evaluating the external impact of land administration and cadastral developments, i.e. how do these developments affect citizens and communities having rights in land? This paper constitutes a review of recently published frameworks related to land administration and cadastral development. The underlying theories are explored and frameworks are identified as belonging to two general groups: those providing recommendations or guidelines, and those providing a hierarchical analysis that conforms to the general structure of evaluation frameworks. This latter category is further explored in terms of the motivations for development of the framework and three sub-groups are identified: those that address a gap in knowledge, those that address issues related specifically to developing contexts, and those with a pro-poor and good governance focus. Finally key lessons are drawn from the reviewed publications. It is proposed that land administration systems should be developed in such a way that they can become successful, sustainable, and significant. To this end good leadership is seen as very important, as are public participation, the (temporary) adoption of fit-for-purpose standards, a focus on providing secure tenure, and good governance. The theoretical underpinning for development should be adaptation or unified theories, not formalisation or replacement theory
Well Played--Vol. 1, No. 1
Creators: name: Davidson, Drew
Publisher: name: Carnegie Mellon University
Year: 2024
Subjects: classificationCode: 330310
subject: Interaction and experience design

description: Minecraft, Beyond Construction and Survival--Sean C. Duncan
Architecture as teambuilding in Left 4 Dead 2--Matt Haselton
Afterland – From well theorized to well learned?--Konstantin Mitgutsch, Matthew Weise
Little Big Planet and Metal Gear Solid 4: Being Old Sack Snake--Caroline C. Williams
Copper ecotoxicology of marine algae: a methodological appraisal
Creators: name: Leal, Pablo P.
name: Hurd, Catriona L.
name: Sander, Sylvia G.
name: Armstrong, Evelyn
name: Roleda, Michael Y.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Marine Biology
subject: Cancer
subject: Inorganic Chemistry
subject: Plant Biology

description: The production of accurate and reliable data on copper ecotoxicology of marine algae depends on the use of trace metal clean techniques during experimentation. We reviewed the methodologies used in the literature on copper ecotoxicology of marine macro- and microalgae, specifically the use of trace metal clean procedures such as the labware used (glassware vs. plasticware), methods of cleaning the labware (acid soaking and ultrapure water rinsing), stock solution preparation (copper source and acidification), and measurement and reporting of dissolved copper concentrations. In terms of taxonomic classification, the most studied algal groups were the Phyla Ochrophyta, Bacillariophyta, Rhodophyta, and Chlorophyta. In terms of methodology, ∼50% of the articles did not specify the labware, ∼25% used glassware, and ∼25% plasticware; ∼30% of the studies specified cleaning protocols for labware to remove trace metal impurities; the copper form used to prepare the stock solutions was specified in ∼80% of studies but acidification to stabilise the dissolved copper was performed in only ∼20%; and the dissolved copper concentration was measured in only ∼40% of studies. We discuss the importance of following trace metal clean techniques for the comparison and interpretation of data obtained on copper ecotoxicology in algae.
title: Factor price distortions, underutilisation of capacity and employment in the large-scale manufacturing sector of Pakistan
Creators: name: Kauser, Rukhsana
Publisher: name: University of Glasgow
Year: 1994
Subjects: subject: Economics, commerce-business, labor economics.

description: This study endeavours to consider ways of removing impediments to increased employment in the large-scale manufacturing sector of Pakistan. The analysis has been carried out mainly in terms of the technological aspect of employment. Factor price distortions and underutilisation of capital are seen as the two major factors affecting employment in the large-scale manufacturing sector of Pakistan. Various forms of government policies have been seen as a source of distortions in relative factor prices which in turn not only encouraged the use of capital-intensive techniques but also created excess capacity in the manufacturing sector. The effect of removing distortions in factor prices on employment depends on the magnitude of the elasticity of substitution. A statistically significant elasticity of substitution between capital and labour was found using the CES production function. The magnitude of the elasticity of substitution between capital and labour is found to be low in overall manufacturing sector but it varies in inter-industry estimates. Some industries show a great potential of increased employment opportunities with respect to real wage rate reductions. On the basis of our statistical results we reject the null hypothesis that factor prices do not play a substantial role in affecting choice of techniques in the large-scale manufacturing sector of Pakistan. Utilisation of capacity to its full maximum can increase employment opportunities in the sector. A large proportion of industries are not utilising their capacity to the full maximum. Our statistical results and the survey analysis support many hypotheses related to the causes of underutilisation of capacity in the large-scale manufacturing sector of Pakistan. We have found the shortage of electricity as one of the major factor affecting capacity utilisation. Overall, supply factors are dominant in affecting the rate of capacity utilisation in Pakistan.
Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways
Creators: name: Qichao Huang
name: Zhan, Lei
name: Haiyan Cao
name: Jibin Li
name: Yinghua Lyu
name: Guo, Xu
name: Zhang, Jing
name: Ji, Lele
name: Tingting Ren
name: Jiaze An
name: Bingrong Liu
name: Yongzhan Nie
name: Jinliang Xing
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Mitochondrial morphology is dynamically remodeled by fusion and fission in cells, and dysregulation of this process is closely implicated in tumorigenesis. However, the mechanism by which mitochondrial dynamics influence cancer cell survival is considerably less clear, especially in hepatocellular carcinoma (HCC). In this study, we systematically investigated the alteration of mitochondrial dynamics and its functional role in the regulation of autophagy and HCC cell survival. Furthermore, the underlying molecular mechanisms and therapeutic application were explored in depth. Mitochondrial fission was frequently upregulated in HCC tissues mainly due to an elevated expression ratio of DNM1L to MFN1, which significantly contributed to poor prognosis of HCC patients. Increased mitochondrial fission by forced expression of DNM1L or knockdown of MFN1 promoted the survival of HCC cells both in vitro and in vivo mainly by facilitating autophagy and inhibiting mitochondria-dependent apoptosis. We further demonstrated that the survival-promoting role of increased mitochondrial fission was mediated via elevated ROS production and subsequent activation of AKT, which facilitated MDM2-mediated TP53 degradation, and NFKBIA- and IKK-mediated transcriptional activity of NFKB in HCC cells. Also, a crosstalk between TP53 and NFKB pathways was involved in the regulation of mitochondrial fission-mediated cell survival. Moreover, treatment with mitochondrial division inhibitor-1 significantly suppressed tumor growth in an in vivo xenograft nude mice model. Our findings demonstrate that increased mitochondrial fission plays a critical role in regulation of HCC cell survival, which provides a strong evidence for this process as drug target in HCC treatment.
Environmentally benign fabrication of calcium hydroxyapatite using seashells collected in Baltic Sea countries: A comparative study
Creators: name: J. Trinkunaite-Felsen
name: H. Birkedal
name: A. Zarkov
name: S. Tautkus
name: Z. Stankeviciute
name: A. Kareiva
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Inorganic Chemistry

description: In this study, high purity crystalline calcium hydroxyapatite (Ca10(PO4)6(OH)2; CHAp) was fabricated from seashells collected in different regions of the Baltic Sea using an environment-friendly water-based sol-gel synthesis route. The phase composition of the synthesized CHAp powders was studied by X-ray diffraction analysis and Fourier transform infrared spectroscopy. The surface morphologies of the precursors and synthesized samples were examined by scanning electron microscopy. A single shell type, Macoma balthica (L.), was collected from various locations around the Baltic Sea. Nevertheless, the resulting CHAp powders had surprisingly large variations in the surface morphology of sol-gel-derived CHAp bioceramics.
Transition-metal-free synthesis of thiocyanato- or nitro-arenes through diaryliodonium salts
Creators: name: Li, Xiao-Hua
name: Liang-Gui Li
name: Mo, Xue-Ling
name: Mo, Dong-Liang
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: A transition-metal-free approach to facile synthesis of thiocyanato- and nitro-arenes was developed from KSCN (potassiumthiocyanate) or NaNO2 with diaryliodonium salts in good yields under mild conditions. The reaction was compatible with a variety of sensitive functional substituents such as halides and nitro and ester groups. The usefulness of arylation products has been realized.
title: The incidence of non-domestic property taxes
Creators: name: Damania, Dicky
Publisher: name: University of Glasgow
Year: 1986
Subjects: subject: Economics, Public administration

description: The thesis endeavours to infer the effective incidence of the non-domestic property tax in the UK. Chapter 1 briefly describes the history of the property tax and the existing rating system. In addition, the chapter examines the formal incidence of the tax and its purported merits and deficiencies. Chapter 2 investigates the neoclassical theory of property tax incidence and focuses on the development of general equilibrium incidence analysis. In contrast, Chapter 3 describes the Post-Keynesian theory of tax incidence and suggests an amendment to a model which is found to yield theoretically inconsistent results. Chapter 4 reviews the existing empirical work on the impact of the non-domestic property tax in the UK. It is argued that most of these studies are based on theoretically inconsistent models, and hence do little to dispel doubts about the incidence of the tax. In an attempt to remedy this deficiency, Chapter 5 develops a theoretical general equilibrium model, which is used to infer the incidence of the non-domestic property tax. The results suggest that much of the non-domestic property tax burden is borne by firms. However, general equilibrium incidence estimates are based on a plethora of stringent assumptions which are merely imposed on the data rather than statistically tested. It would therefore seem useful to use an alternative procedure to estimate the impact of the non-domestic property tax. Chapter 6 thus examines the various quantitative techniques employed in public finance to infer the incidence of taxes. It is suggested that econometric procedures, while not perfect, provide a method for discriminating between competing theories and deriving data coherent estimates of tax incidence. Chapter 7 develops an econometric model which is used to infer the degree of short run property tax shifting. The investigation is based on a theoretically derived model of mark-up pricing. The chapter further examines the process by which agents form expectations of output and costs, and the impact of demand factors on prices and the mark-up. The results suggest that much of the non-domestic property tax burden is borne by firms. The chapter ends with a discussion of the theoretical implications of the empirical exercise. Finally, Chapter 8 summarises the main results of the study and emphasises the contribution of incidence theory. The thesis concludes with suggestions for future empirical and theoretical research.
title: Improving energy access in rural areas
title: How to incentivize the transition to modern energy solutions in rural India
titleType: AlternativeTitle
Creators: name: Gaur, Varun
name: Haluska, Nicholas
Publisher: name: Center for Development Research (ZEF)
Year: 2019
Subjects: subject: India
subject: Energy
subject: ddc:333.7

description: Access to energy remains a critical issue around the globe. At least 1.3 billion people worldwide do not have adequate access to electricity. Due to the unreliability of the electricity supply, power outages are frequent in many rural areas across the developing world where 84% of those without connection to power grids reside. Moreover, 2.6 billion people globally are unable to access clean cooking technologies.
 India is among the countries most affected by these challenges. India faces an enormous energy poverty challenge with around two-thirds of its population dependent on traditional bioenergy-based cooking and heating while around 45% of its households lack access to electricity. To augment energy access, the Indian government has launched several energy programs. However, these initiatives are still falling short of ensuring a transition to modern energy systems. It is therefore critical to devise strategies that enable rural households to transition towards a smart mix of modern energy sources.
 This policy brief summarizes insights from research conducted in India which investigated the factors that drive the adoption of modern energy in the country.
title: Monetary and fiscal policy, the exchange rate, and foreign wealth
Creators: name: Tirelli, Patrizio
Publisher: name: University of Glasgow
Year: 1990
Subjects: subject: Economics, Finance

description: The theory of macroeconomic policy is now in a difficult position. After the demise of the old keynesian orthodoxy, dissatisfaction has grown with monetarist ideas, too. This thesis aims to contribute to the search for a new framework for macroeconomic policy. Throughout the thesis great emphasis is put on two key ideas. The first is that both monetary and fiscal policy should be used in a well designed policy package. Such a policy package should consist of "simple" rules, on the grounds that simple rules, more easy to understand and monitor in the eyes of the private sector, would enhance the credibility of the government's pre-commitment. The second idea is that foreign wealth accumulation, operating through cumulating current account imbalances, plays a key role in the determination of the open economy macroeconomic equilibrium and its stability. Therefore open economy models should include wealth effects and the current account. Furthermore, policy evaluation should take into account, among other things, the Implications of alternative rules on foreign wealth. We shall consider policy design both in a "small" individual country and in the broader context of policy coordination.
Efficient continuous kinetic resolution of racemic 2-aminobutanol over immobilized penicillin G acylase
Creators: name: Jianxin Wang
name: Liu, Na
name: Xiaobo Cheng
name: Ligong Chen
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: In this paper, an efficient method was established for continuous kinetic resolution of racemic 2-aminobutanol by selective hydrolysis of N-phenylacetyl (±)-2-aminobutanol over immobilized penicillin G acylase (PGA) in a fixed-bed reactor. Several N-acylated derivatives of 2-aminobutanol were screened in batch experiments, and it was found that the hydrolysis of N-phenylacetyl (±)-2-aminobutanol proceeded smoothly in the presence of immobilized penicillin G acylase with satisfied enantioselectivity. Thus, the reaction parameters were optimized in a fixed-bed reactor. Under the optimized conditions, 39.3% conversion of N-phenylacetyl (±)-2-aminobutanol and 98.2% ee value of S-2-aminobutanol were obtained. This fixed-bed system was operated continuously for 40 h without significant decrease of enzyme activity. It has been demonstrated to be more efficient compared to the batch experiments.
Well Played 1.0: Video Games, Value and Meaning
Creators: name: Davidson, Drew
Publisher: name: Carnegie Mellon University
Year: 2024
Subjects: classificationCode: 330310
subject: Interaction and experience design

description: IVideo games can be “well played” in two senses. On the one hand, well played is to games as well read is to books. On the other hand, well played as in well done. This book is full of in-depth close readings of video games that parse out the various meanings to be found in the experience of playing a game. 22 contributors (developers, scholars, reviewers and bloggers) look at video games through both senses of “well played.” The goal is to help develop and define a literacy of games as well as a sense of their value as an experience. Video games are a complex medium that merits careful interpretation and insightful analysis.
Transition Metal-Free Synthesis of Thiocyanato- or Nitro-Arenes through Diaryliodonium Salts
Creators: name: Li, Xiao-Hua
name: Liang-Gui Li
name: Mo, Xue-Ling
name: Mo, Dong-Liang
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: A transition metal-free approach to facile synthesis of thiocyanato- and nitro-arenes was developed from KSCN or NaNO2 with diaryliodonium salts in good yields under mild conditions. The reaction was compatible with a variety of sensitive functional substituents such as halides, nitro, and ester groups. The usefulness of arylation products has been realized.
Organic selenium compounds: Synthesis and reactions of some new 7-alkyl-8-selenotheophyllines
Creators: name: Gobouri, Adil A.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Plant Biology
subject: 60506 Virology

description: A simple and mild synthesis of selenotheophyllines is described based on the reaction of 7-alkyl-8-chlorotheophylline with sodium hydrogenselenide followed by reactions with halocompounds such as chloroacetonitrile, ethyl chloroacetate, chloroacetamide, and ethyl chloroformate. Elemental analysis, infrared, 1H NMR, 13C NMR, and mass spectral data confirmed the structure of the newly synthesized compounds.
Relaunching the Open Education Policy Registry
Creators: name: Neumann, Jan
name: Havemann, Leo
name: Atenas, Javiera
name: Nascimbeni, Fabio
Publisher: name: Zenodo
Year: 2020
Subjects: open education
policy
OER

description: Post on OER World Map Blog, providing an update on the development of the OE Policy Registry. Originally published at https://oerworldmap.wordpress.com/2020/02/19/relaunching-the-open-education-policy-registry/
An Efficient Continuous Kinetic Resolution of Racemic 2-aminobutanol over Immobilized Penicillin G Acylase
Creators: name: Jianxin Wang
name: Liu, Na
name: Xiaobo Cheng
name: Ligong Chen
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: In this paper, an efficient method was established for continuous kinetic resolution of racemic 2-aminobutanol by selective hydrolysis of N-phenylacetyl (±)-2-aminobutanol over immobilized penicillin G acylase (PGA) in a fixed-bed reactor. Several N-acylated derivatives of 2-aminobutanol were screened in batch experiments, it was found that the hydrolysis of N-phenylacetyl (±)-2-aminobutanol proceeded smoothly in the presence of immobilized penicillin G acylase with satisfied enantioselectivity. Thus, the reaction parameters were optimized in a fixed-bed reactor. Under the optimized conditions, 39.3% conversion of N-phenylacetyl (±)-2-aminobutanol and 98.2% ee value of S-2-aminobutanol were obtained. This fixed-bed system was operated continuously for 40 hours without significant decrease of enzyme activity. It has been demonstrated to be more efficient compared to the batch experiments.
Significantly enhanced tumor cellular and lysosomal hydroxychloroquine delivery by smart liposomes for optimal autophagy inhibition and improved antitumor efficiency with liposomal doxorubicin
Creators: name: Wang, Yang
name: Kairong Shi
name: Zhang, Li
name: Guanlian Hu
name: Jingyu Wan
name: Jiajing Tang
name: Yin, Sheng
name: Jiandong Duan
name: Qin, Ming
name: Wang, Neng
name: Dandan Xie
name: Xinle Gao
name: Huile Gao
name: Zhirong Zhang
name: He, Qin
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Hydroxychloroquine (HCQ) inhibits autophagy and therefore can sensitize some cancer cells to chemotherapy, but the high doses required limit its clinical use. Here we show that loading HCQ into liposomes (HCQ/Lip) decorated with a pH-sensitive TH-RGD targeting peptide (HCQ/Lip-TR) can concentrate HCQ in B16F10 tumor cells and lysosomes. HCQ/Lip-TR was efficiently internalized as a result of its ability to bind ITGAV-ITGB3/integrin αvβ3 receptors highly expressed on the tumor cell surface and to undergo charge reversal from anionic at pH 7.4 to cationic at pH 6.5. Studies in vitro at pH 6.5 showed that the intracellular HCQ concentration was 35.68-fold higher, and lysosomal HCQ concentration 32.22-fold higher, after treating cultures with HCQ/Lip-TR than after treating them with free HCQ. The corresponding enhancements observed in mice bearing B16F10 tumors were 15.16-fold within tumor cells and 14.10-fold within lysosomes. HCQ/Lip-TR was associated with milder anemia and milder myosuppressive reductions in white blood cell and platelet counts than free HCQ, as well as less accumulation in the small intestine, which may reduce risk of intestinal side effects. In addition, co-delivering HCQ/Lip-TR with either free doxorubicin (DOX) or liposomal DOX improved the ability of DOX to inhibit tumor growth. Biochemical, electron microscopy and immunofluorescence experiments confirmed that HCQ/Lip-TR blocked autophagic flux in tumor cells. Our results suggest that loading HCQ into Lip-TR liposomes may increase the effective concentration of the inhibitor in tumor cells, allowing less toxic doses to be used.
Ullmann diaryl ether synthesis catalyzed by copper (I)/pyridine-functionalized silane
Creators: name: Baohua Zhang
name: Lanxiang Shi
name: Ruixia Guo
name: Sijie Liu
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Ullmann-type diaryl ether synthesis was performed under mild conditions in DMF/K2CO3 using a pyridine-functionalized silane as a ligand. The products were obtained in good yields. This method tolerates a variety of functional groups and is effective in the synthesis of hindered diaryl ethers and heteroaryl ethers.
Reaction pathway of POCl3-mediated Knoevenagel condensation of bisulfite adducts with 2,4-thiazolidinedione
Creators: name: Mohanty, Sandeep
name: Amrendra Kumar Roy
name: Reddy, Sandeep
name: Kuchipudi Pavithran Vinay Kumar
name: Karmakar, Arun Chandra
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Neuroscience
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Plant Biology

description: We investigated the POCl3-mediated transformation of aromatic bisulfite adducts to the corresponding 5-arylidenethiazolidine-2,4-diones. The in situ transformation of an aromatic bisulfite adduct to the parent aldehyde in a non-aqueous non-polar solvent (toluene) was demonstrated using DoE (Design of experiment), offline 1H NMR, online ReactIR, HPLC, LC-MS, and GC-MS. By means of these analytical tools, we determined, for the first time, the structure of the intermediate species (aldehyde) prior to the carbon–carbon double-bond formation. The carbon–sulfur bond undergoes a fast cleavage, immediately after the addition of POCl3, which finally affords the corresponding 5-arylidenethiazolidine-2,4-diones.
Synthesis and antiviral activity of novel thioether derivatives containing 1,3,4-oxadiazole/thiadiazole and emodin moieties
Creators: name: Liangrun Dong
name: Baojing Song
name: Wu, Jian
name: Zengxue Wu
name: Yunying Zhu
name: Xuewen Chen
name: Deyu Hu
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology

description: A series of novel thioether derivatives containing 1,3,4-oxadiazole/thiadiazole and emodin moieties were designed and synthesized. The structures of the target compounds were confirmed by 1H NMR, 13C NMR, Infrared, and elemental analysis. The results of bioactivity analysis showed that most of the target compounds exhibited moderate to good antiviral activity against tobacco mosaic virus at a concentration of 500 mg/L. Especially, among the title compounds, Y2, Y8, and Y10 possessed appreciable curative activity in vivo, with inhibition rates of 50.51, 52.08, and 54.62%, respectively, which were similar to that of Ningnanmycin (53.40%).
Well Played -- Vol.5, No.2
Creators: name: Davidson, Drew
Publisher: name: Carnegie Mellon University
Year: 2024
Subjects: classificationCode: 330310
subject: Interaction and experience design

description: PART 1: DIGRA

EVE is Real: How conceptions of the 'real'affect and reflect an online game community
Playing Across Media: Exploring Transtextuality in Competitive Games and eSports
Authentic Portrayals of Game Culture? AContent Analysis of the Crowd-funded YouTube Documentary The Smash Brothers

PART 2: GAMES LEARNING SOCIETY

Love Is a Battlefield: A Comparative Analysis of Love as a Game Mechanic and Sartre’s Being and Nothingness
Rocksmith 2014 – 60 Days of Variety,Feedback and Missions
Intergenerational Gaming in Kerbal Space Program How I Learned to Stop Worrying and Love Youth AR Game Creation
He Was The Most...Human: Ethical Play in Doki Doki Universe
Prepare to Suffer with Paul & Mo: Let’s Play as Well Played
“Any% No Sketch Glitch”: Speedrunning Final Fantasy VI and Expanding “Well Played”
Ingress Well-Played: City as MMO
Finding the beat: Cycles of expertise in rhythm games
Well Played -- Vol. 7, No. 2
Creators: name: Rivers, Susan E.
Publisher: name: Carnegie Mellon University
Year: 2024
Subjects: classificationCode: 330310
subject: Interaction and experience design

description: iThrive Games Founder’s Letter
 Dorothy N. Batten
Introduction to the Special Issue: Thriving Through Gameplay
 Susan E. Rivers
Prosocial Religion and Games: Lost & Found
 Owen Gottlieb and Ian Schreiber
Skazka: Exploring Empathy Through Cooperative Mechanics and Narrative
 Sarah A. Abraham
GUIDE and Dangerous Play: An Empathetic Game About Coping and Resilience
 Rebecca Goodine, Jade A. Yhap, and Jeffrey T. Mundee
Butterfly Lovers: Design Rationale of a Cooperative Virtual Reality Game for Promoting Compassion in Multigenerational Families
 Jessica Cheng, Sydney Rubin, Christina Lelon, Xian Lu, Jeffrey Doan, Patrick Bender, Ashley Yu-Chih, Brenda Chen, Nathan Lim, Gabrielle Kanellos, Kelsey Rice, Maryalice Jordan-Marsh, & Marientina Gotsis
Kisima Inŋitchuŋa (Never Alone) As Cultural Survivance: The Potential of Video Games to Support Indigenous Well-being
 Jennifer C. Stone
Beyond Empathy: Games to Foster Teens’ Social and Emotional Skills
 Kelli N. Dunlap & Susan E. Rivers
Design and synthesis of novel α-substituted phosphonic acids catalyzed by nano zinc oxide
Creators: name: Yalda Shaabani
name: Ghassamipour, Soheila
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 60506 Virology

description: A series of α-substituted phosphonic acids were synthesized by a reaction between dimedone, aromatic aldehydes, and triethylphosphite in ethanolic solution under reflux conditions and using nano zinc oxide as a catalyst. Their structures were determined by Infrared, carbon, hydrogen, nitrogen, and sulfur analysis, 1H-NMR, 13C-NMR, and 31P-NMR.
Well Played -- Vol. 7, No. 1
Creators: name: Fay, Ira
Publisher: name: Carnegie Mellon University
Year: 2024
Subjects: classificationCode: 330310
subject: Interaction and experience design

description: Distribution, Deckbuilding, and Design in Star Wars: The Card Game
 Nick Bestor
No Time to Waste: Kairos in T.I.M.E Stories
 Sven Dwulecki
Seeing but not observing with Sherlock Holmes the Consulting Detective
 Tapani N. Joelsson
Why should I play to win if I can pay to win?: Economic inequality and its influence on the experience of non-digital games
 Patrick Maisenhölder
Stacking Magic: The Flexible Simplicity of Analog Rules
 Eric Murnane & Kenton Howard
Sketchventor: Evolving Ideations by Design
 Anthony Pellicone, Kathryn Kaczmarek Frew, Elizabeth Bonsignore, Derek Hansen, Skylar Hoffman, & Kari Kraus
From a Board Game to a Drinking Game: One Biography of the Finnish Board Game Kimble
 Lilli Sihvonen
The Lord of the Rings: The Card Game A Machine That Generates Possible Worlds
 Michał Żmuda
Three-component reactions of phosphorus ylides, thiophenols, and acetyl chloride for the synthesis of (β-thioacrylates)
Creators: name: Yunyun Liu
name: Huang, Bin
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 69999 Biological Sciences not elsewhere classified

description: The facile synthesis of β-thioacrylates has been realized via direct three-component reactions of thiophenols, Wittig reagents, and acetyl chloride. Under transition metal-free conditions, a class of β-thioacrylates have been synthesized with fair to excellent yields via cascade C=C double bond and C(sp2)-S bond formation.
Well Played -- Vol. 6, No. 3
Creators: name: Davidson, Drew
Publisher: name: Carnegie Mellon University
Year: 2024
Subjects: classificationCode: 330310
subject: Interaction and experience design

description: Agency, Identity, Sex, Gender, and Pokémon Go Allison Bannister
So Close You Can Feel Her: Prostitution, Proximity & Empathy in Grand Theft Auto5 Elena Bertozzi, Amelia Bertozzi-Villa
Learning at the Farm: Developmental Psychology in Peekaboo Barn Carly A. Kocurek, Jennifer L. Miller
Taking Over the World, Again? Examining Procedural Remakes of Adventure Games Anastasia Salter
Synthesis and interfacial activity of petroleum sulfonate
Creators: name: W.-H. Li
name: Y.-Q. Zhang
name: L.-C. Wang
name: Y. Guo
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Four petroleum sulfonates including first vacuum distillate sulfonate, second vacuum distillate sulfonate, third vacuum distillate sulfonate, and vacuum residue sulfonate were synthesized. The tensions of the petroleum sulfonates were measured. It shows that the third vacuum distillate sulfonate can produce ultralow interfacial tension when the concentrations are higher than 0.010%. Synergism between Na2SO4 and CaCl2 (or MgCl2) in the formation water was proved, which is crucial to reduce the tension. Moreover, synergism between the second and third vacuum distillate sulfonates occurs. This work is useful for enhanced oil recovery.
N-isocyaniminotriphenylphosphorane (Ph3PNNC) as an efficient reagent for the synthesis of ferrocene-containing 1,3,4-oxadiazole derivatives
Creators: name: Ramazani, Ali
name: Fattahi, Nadia
name: Ashtari, Mona
name: Rezaei, Aram
name: Joo, Sang Woo
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Neuroscience
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology

description: Reaction of N-isocyaniminotriphenylphosphorane (Ph3PNNC) with an aromatic aldehyde in the presence of ferrocene carboxylic acid and a secondary amine proceeds smoothly at room temperature under neutral conditions to afford sterically congested ferrocene-containing 1,3,4-oxadiazole derivatives in high yields. The reaction progresses smoothly and clearly under mild conditions and no side reactions were observed.
More than good intentions: the role of conditions in personal transportation behaviour
Creators: name: Biggar, Matt
name: Ardoin, Nicole M.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Engaging individuals in pro-environmental behaviours is critical to addressing today’s environmental challenges. This study examines how conditions – or an individual’s context – influence action. Through semi-structured narrative interviews and document analysis, we examined the influence of conditions in five individual cases involving attempted change in personal transportation behaviour. The cases, studied over the course of one year, are derived from participants in a sustainability institute, representing a range of attempted behaviours, and highlight numerous potential barriers to desired pro-environmental behaviours. We found that the degree of engagement with sustainable transportation primarily was influenced by the amount and intensity of supportive conditions relative to barriers. Participants who successfully engaged in their desired transportation-related pro-environmental behaviours experienced physical, social, and learning conditions that promoted competence and satisfaction. We discuss the implications for designing interventions that encourage pro-environmental behaviours.
title: An analysis of the contemporary governance of Glasgow, 1975-2000
Creators: name: McWilliams, Christopher
Publisher: name: University of Glasgow
Year: 2002
Subjects: subject: Political science
subject: FOS: Political science

description: This research sought to investigate the effectiveness of the 'new urban governance' in addressing the problems experienced by disadvantaged communities in a deindustrialised city. This was achieved by examining the changing structure and process of contemporary urban governance in Glasgow and how this has impacted upon urban policy developments. Central to the 'new urban governance' is the pursuit of urban entrepreneurial policies, which it is claimed are in the best interest of all the city's residents. However, in the case of Glasgow, the above is debatable. This research demonstrated how Glasgow policy makers developed a strategy that favoured business in the city centre over other areas of the city. This in turn, resulted in the emergence of a 'dual urban policy'. Within this context, urban policies pursued and adopted by city decision makers still fundamentally matter to the quality of life of all citizens. In striving to provide the fullest explanation with regards to the nature of contemporary urban governance in Glasgow this study adopted a political-economy approach. While previous research attempts have investigated the emergence of a 'new urban politics', analysis to date has been far from complete or comprehensive. The exact lineaments and nature of the 'new urban governance' are open to dispute and can differ from place to place. A further key finding of this research has shown how Glasgow does not fit neatly into any ideal type of local governance. This research has shown that while regime and regulation theory can assist in improving our understanding of the 'new urban governance' they are limited in their analysis. This research argues that a fusion of both theories enables a deeper understanding of contemporary urban governance. In the case of Glasgow, while there is no shortage of research into urban regeneration, there is a lack of any comprehensive analysis regarding the governance of the city. This research has significantly contributed to the aforementioned debate in that for the first time the nature of contemporary governance in Glasgow has been contextualised. The effectiveness of social inclusion policies designed to address the problems of disadvantaged neighbourhoods has also been examined in this work. Specifically this study draws upon detailed research material obtained from a case-study of the 'Greater Pollok' social inclusion partnership. The difficulties of including the local community in urban decision making was identified and that recent top-down partnership structures only serve to legitimate and help implement policy decisions taken by powerful non locally-accountable regeneration agencies.