title: Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° ÐºÐ¾Ð¼Ð¿Ð¾Ð·Ð¸ÑÐ¸Ð¾Ð½Ð½ÑÑ Ð¼Ð°ÑÑÐ¸Ñ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ñ Ð¸ÑÐ¾Ð·Ð°Ð½Ð° Ñ Ð´Ð¾Ð±Ð°Ð²Ð»ÐµÐ½Ð¸ÐµÐ¼ ÑÐ°ÑÑÐ¸Ñ Ð³Ð¸Ð´ÑÐ¾ÐºÑÐ¸Ð°Ð¿Ð°ÑÐ¸ÑÐ° Ð´Ð»Ñ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð² ÑÐºÐ°Ð½ÐµÐ²Ð¾Ð¹ Ð¸Ð½Ð¶ÐµÐ½ÐµÑÐ¸Ð¸
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Development of composite matrices based on chitosan with the addition of hydroxyapatite particles for use in tissue engineering
Creators: name: ÐÐ¾Ð²Ð¾ÑÐ°Ð´, Ð®ÑÐ¸Ð¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: Ñ Ð¸ÑÐ¾Ð·Ð°Ð½Ð¾Ð²ÑÐµ Ð¼Ð°ÑÑÐ¸ÑÑ
Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸ÑÑ Ð³Ð¸Ð´ÑÐ¾ÐºÑÐ¸Ð°Ð¿Ð°ÑÐ¸ÑÐ°
ÑÐºÐ°Ð½ÐµÐ²Ð°Ñ Ð¸Ð½Ð¶ÐµÐ½ÐµÑÐ¸Ñ
ÐºÐ¾ÑÑÐ½Ð°Ñ Ð¿Ð»Ð°ÑÑÐ¸ÐºÐ°
Ð»Ð¸Ð¾ÑÐ¸Ð»ÑÐ½Ð°Ñ ÑÑÑÐºÐ°
chitosan scaffolds
hydroxyapatite nanoparticles
tissue engineering
bone plastic
freeze drying

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description: In the course of the work, a method for obtaining bulk porous matrices based on chi-tosan reinforced with hydroxyapatite nanoparticles, which can be used as a tissue-engineering drug in the treatment of bone defects was developed. To create tissue engineer-ing structures, was used the method of lyophilic drying of samples, based on the sublima-tion of a liquid from a frozen solution. A study of the rheological properties of a chitosan solution reinforced with hydroxyapatite showed that its effective viscosity decreases with increasing shear rate. During heat treatment of lyophilized samples in the temperature range from 20 0Ð¡ to 150 0C in an inert environment, their mass falls, but the loss is insig-nificant (&lt;5%). The adding of hydroxyapatite nanoparticles into chitosan improves the me-chanical characteristics of porous matrices, making them more durable to certain impurity concentrations, exceeding which leads to a decrease in the strength of the matrices. Cyto-logical analysis showed that the developed material can be used as a tissue-engineering preparation, since the cells cultured on it proliferate and do not undergo necrosis. The ease of operation and speed of resorption of porous chitosan matrices are noted in in vivo tests. As shown by histological studies, an area filled with fibrous cartilage is formed in place of the porous matrix, which indicates the beginning of primary processes of bone tissue resto-ration. All the above points indicate that the material can be used as a tissue engineering structure and to restore the volume of the bone defect.