cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Laser pointer prohibition: improving safety or driving misclassification
Creators: name: Wheatley, Trevor A
Publisher: name: arXiv
Year: 2014
Subjects: subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences

description: It is well known that since 2008 Australia has had some of the world's most restrictive laws regarding the possession and importation of "laser pointers" with powers exceeding 1 mW. Now four years on Australia is used as a test case and question whether this has actually improved safety for those wishing to purchase these devices or if it has impacted on the availability of prohibited devices. Results from the analysis of over 40 laser pointers legitimately purchased in Australia from local and International suppliers are presented. Specifically lasers that are readily available to everyday consumers through the simple on-line search "laser pointer 1mw" are targeted. The parameters investigated are quoted power versus measured power, correct representation in advertising and adherence to laser standards as related to specified use and purchase price. The analysis indicates that the suppliers in this market have learnt how to bypass the prohibition and the impact on general safety in these cases is detrimental.
description: Presented at the International Laser Safety Conference (ILSC), Orlando, Florida, March 2013
The impact of artificial destratification on water quality in Chaffey Reservoir
Creators: name: Sherman, Bradford
name: Whittington, John
name: Oliver, Rod
Publisher: name: La Trobe
Year: 2023

description: La Trobe University Faculty of Science, Technology and Engineering Murray Darling Freshwater Research Centre

MDFRC item.

Reservoir management strategies for the control of toxic cyanobacterial blooms assume that algae can be starved of light or nutrients, especially phosphorus. The failure of a bubble-plume destratification system to control blue-green algal blooms in Chaffey Reservoir, Australia, had two causes: its inability to deepen the surface mixed layer (SML) significantly despite markedly reducing the top-to-bottom temperature difference; and the high external filterable reactive phosphorus (FRP) load originating in the upstream catchment. Temperature differences as small as 0.04 degree C prevented downwards mixing of buoyant Anabaena which inhabited the SML. Artificial destratification reduced the internal phosphorus load from the sediments by over 80% compared to the internal load observed during stratified anoxic conditions. However, the annual external FRP load was at least as large as the internal load. Identification and control of the external FRP load is vital if the biomass potential of future algal blooms is to be reduced.
Genome-wide protein–DNA binding dynamics suggest a molecular clutch for transcription factor function
Creators: name: Lickwar, Colin R.
name: Hanlon, Sean E.
name: Mueller, Florian
name: Lieb, Jason D.
name: McNally, James G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Dynamic access to genetic information is central to organismal development and environmental response. Consequently, genomic processes must be regulated by mechanisms that alter genome function relatively rapidly1-4. Conventional chromatin immunoprecipitation (ChIP) experiments measure transcription factor (TF) occupancy5, but are blind to kinetics and are poor predictors of TF function at a given locus. To measure TF binding dynamics genome-wide, we performed competition ChIP6,7 with a sequence-specific S. cerevisiae transcription factor, Rap18. Rap1 binding dynamics and Rap1 occupancy were only weakly correlated (R2 = 0.14), but binding dynamics were more strongly linked to function than occupancy. Long Rap1 residence was coupled to transcriptional activation, while fast binding turnover, which we term “treadmilling”, was linked to low transcriptional output. Thus, DNA-binding events that appear identical by conventional ChIP may have starkly different underlying modes of interaction that lead to opposing functional outcomes. We propose that TF binding turnover is a major point of regulation in determining the functional consequences of transcription factor binding, and is mediated in large part by control of competition between TFs and nucleosomes. Our model (Supplementary Fig. 1) predicts a clutch-like mechanism that rapidly engages a treadmilling transcription factor into a stable binding state, or vice-versa, to modulate TF function.
Memorandum for Hunt Building Company, Randolph Family Housing Scope of Work, Randolph Air Force Base
Creators: name: Shepherd, Scott B.
Publisher: name: Department of the Air Force, Air Education and Training Command
Year: 2011
Subjects: subject: Randolph Field
valueUri: https://core.tdar.org/browse/geographic-keyword/82870/randolph-field
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Randolph Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/78971/randolph-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: NRHP
valueUri: https://core.tdar.org/browse/other-keyword/9857/nrhp
subject: National Register of Historic Places
valueUri: https://core.tdar.org/browse/other-keyword/1572/national-register-of-historic-places
subject: Building 300
valueUri: https://core.tdar.org/browse/other-keyword/152892/building-300
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Historic Background Research
valueUri: https://core.tdar.org/browse/investigation-type/18/historic-background-research
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: Memorandum from Cultural Resources Manager sent to Hunt Building Company regarding the involvement of Building 300 in a proposed Randolph Family Housing Scope of Work. It was determined Building 300 is listed on the National Register of Historic Places, and is located within the Randolph Field Historic Landmark District. After reviewing the proposed Scope of Work and our discussion of the project, it was determined that the action will have no adverse effect on the historic property or on the landmark district.
Phenomenological study of the $B_{c}$ ${\to}$ $BP$, $BV$ decays with perturbative QCD approach
Creators: name: Sun, Junfeng
name: Yang, Yueling
name: Chang, Qin
name: Lu, Gongru
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Inspired by the recent LHCb measurements and forthcoming great potential on $B_{c}$ meson, we study the exclusive $B_{c}$ ${\to}$ $B_{q}P$, $B_{q}V$ decays with the perturbative QCD approach, where $q$ $=$ $u$, $d$, $s$; $P$ and $V$ denote the lightest pseudoscalar and vector $SU(3)$ nonet meson, respectively. By retaining the quark transverse momentum, employing the Sudakov factors, and choosing the typical scale as the maximum virtualities of the internal particles, we calculate the $B_{c}$ ${\to}$ $B$ transition from factors, and our results show that about 90\% contribution to form factors come from the $α_{s}/π$ $
description: 32 pages, 7 figures, revtex4
PaNOSC key achievements in first 18 months
Creators: name: Carboni, Nicoletta
name: Gotz, Andy
Publisher: name: Zenodo
Year: 2020
Subjects: PaNOSC
EOSC
FAIR

description: PaNOSC is a European project financed by the INFRAEOSC-04 call for making FAIR data a reality in six European Research Infrastructures (RIs) for photon and neutron science, developing and providing services for scientific data, and connecting these to the European Open Science Cloud (EOSC). This document summarises the main achievements after the first 18 months.
Additional file 1 of Recruitment of general practitioners in China: a scoping review of strategies and challenges
Creators: name: Chen, Shiwei
name: Sam, Xin Hui
name: Soong, Aijia
name: Car, Lorainne Tudor
name: Lian, Siqing
name: Smith, Helen E.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1.
Property Photograph Form, Building 179 The Eisenhower House, Fort Sam Houston, Texas
Creators: name:  Burns
Publisher: name: Fourth Army Central Photograph, US Army
Year: 1970
Subjects: subject: JBSA-Sam Houston
valueUri: https://core.tdar.org/browse/geographic-keyword/82532/jbsa-sam-houston
subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Domestic Structures
valueUri: https://core.tdar.org/browse/site-type/256/domestic-structures
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: House
valueUri: https://core.tdar.org/browse/site-type/259/house
subject: Historic Church / Religious Structure
valueUri: https://core.tdar.org/browse/site-type/313/historic-church-religious-structure
subject: Domestic Structure or Architectural Complex
valueUri: https://core.tdar.org/browse/site-type/251/domestic-structure-or-architectural-complex
subject: The Eisenhower House
valueUri: https://core.tdar.org/browse/other-keyword/146767/the-eisenhower-house
subject: Artillary Post Road
valueUri: https://core.tdar.org/browse/other-keyword/146768/artillary-post-road
subject: Building 179
valueUri: https://core.tdar.org/browse/other-keyword/146326/building-179
subject: Fort Sam Houston
valueUri: https://core.tdar.org/browse/other-keyword/42858/fort-sam-houston
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Historic Background Research
valueUri: https://core.tdar.org/browse/investigation-type/18/historic-background-research
subject: Architectural Survey
valueUri: https://core.tdar.org/browse/investigation-type/2/architectural-survey
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: The National Register of Historic Places Property Photograph Form, with accompanying photographs, for Building 179 at Fort Sam Houston, Texas.
Landscape of transcription in human cells
Creators: name: Rozowsky, Joel
name: Chakrabortty, Sudipto
name: Davis, Carrie A.
name: Chen, Xian
name: Antoshechkin, Igor
name: Djebali, Sarah
name: Lin, Wei
name: Lagarde, Julien
name: Tanzer, Andrea
name: Merkel, Angelika
name: Abdelhamid, Rehab F.
name: Schlesinger, Felix
name: Baer, Michael T.
name: Marinov, Georgi K.
name: Dobin, Alex
name: Bell, Kimberly
name: Alioto, Tyler
name: Derrien, Thomas
name: Drenkow, Jorg
name: Bar, Nadav S.
name: Chrast, Jacqueline
name: Williams, Brian A.
name: Röder, Maik
name: Curado, Joao
name: Zaleski, Chris
name: Lassmann, Timo
name: Mortazavi, Ali
name: Batut, Philippe
name: Kokocinski, Felix
name: Khatun, Jainab
name: Xue, Chenghai
name: Bell, Ian
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Eukaryotic cells make many types of primary and processed RNAs that are found either in specific sub-cellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic sub-cellular localizations are also poorly understood. Since RNA represents the direct output of the genetic information encoded by genomes and a significant proportion of a cell’s regulatory capabilities are focused on its synthesis, processing, transport, modifications and translation, the generation of such a catalogue is crucial for understanding genome function. Here we report evidence that three quarters of the human genome is capable of being transcribed, as well as observations about the range and levels of expression, localization, processing fates, regulatory regions and modifications of almost all currently annotated and thousands of previously unannotated RNAs. These observations taken together prompt to a redefinition of the concept of a gene.
Quantum Correlations in Cavity QED Networks
Creators: name: Orszag, Miguel
name: Ciobanu, Nellu
name: Coto, Raul
name: Eremeev, Vitalie
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present a Review of the dynamical features such as generation, propagation, distribution, sudden transition and freezing of the various quantum correlation measures, as Concurrence, Entanglement of Formation, Quantum Discord, as well their geometrical measure counterparts within the models of Cavity Quantum Electrodynamics Networks. Dissipation and thermal effects are discussed both in the generation of quantum correlations as well as their effect on the sudden changes and freezing of the classical and quantum correlations in a cavity quantum electrodynamical network. For certain initial conditions, double transitions in the Bures geometrical discord are found. One of these transitions tends to disappear at a critical temperature
description: 31 pages,15 figures, to appear in Journal of Modern Optics
Pew Research Center: American Trends Panel Wave 85
Creators: name: Pew Research Center
Publisher: name: Roper Center for Public Opinion Research
Year: 2022

description: Awareness of current events (1); relationship between media and current administration (1); preferences for current events sources (4); opinion on different news sources (2); trust in accuracy of political information from different sources (1); comparison of news sources (1); classification of "mainstream" news media (1); personal attention on sources cited in a news story (2); factors that determine whether news is trustworthy (1); news coverage on Biden administration (4); main issues covered during Biden administration (2); knowledge of Biden administration's efforts through news (3); up to date information on coronavirus vaccinations in USA (2); following news about coronavirus outbreak (3); usage of Twitter (2).
The Curriculum Evaluation of the Bachelor of Arts Program in Home Economics (Revised, B.E. 2561) Faculty of Education, Ramkhamhaeng University
Creators: name: Muanpare Rattanasiri
Publisher: name: DR.KEN Institute of Academic Development and Promotion.
Year: 2023
Subjects: Curriculum Evaluation
Department of Home Economics
Ramkhamhaeng University

description: Interdisciplinary Academic and Research Journal, 3, 3, 697-712
Response from Claudia Nissley to Joseph Logan, Interior Rehabilitation of Hangar 12, Randolph Air Force Base, Texas
Creators: name: Nissley, Claudia
Publisher: name: Advisory Council on Historic Preservation
Year: 1992
Subjects: subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Randolph Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/78971/randolph-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: Military Structure
valueUri: https://core.tdar.org/browse/site-type/322/military-structure
subject: Non-Domestic Structures
valueUri: https://core.tdar.org/browse/site-type/309/non-domestic-structures
subject: Hangar 13
valueUri: https://core.tdar.org/browse/other-keyword/158749/hangar-13
subject: Hangar 12
valueUri: https://core.tdar.org/browse/other-keyword/158750/hangar-12
subject: Hangar 64
valueUri: https://core.tdar.org/browse/other-keyword/158727/hangar-64
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: The Advisory Council has reviewed Randolph Air Force Base's documentation on no adverse effect determination for the proposed interior rehabilitation of Hangar 12. The Council concurs with the determination of no adverse effect. This letter is part of a group of correspondence concerning rehabilitation projects for Hangars 12, 13, and 64 at Randolph Air Force Base, Texas. Proposed projects includes new entrance canopies, replacement of external doors, and interior rehabilitation.
Restriction of intestinal stem cell expansion and the regenerative response by YAP
Creators: name: Magness, Scott T.
name: Camargo, Fernando D.
name: Morikawa, Teppei
name: Shrestha, Kriti
name: Yan, Kelley S.
name: Kuo, Calvin J.
name: de la Rosa, Rosemarie
name: Barry, Evan R.
name: Smits, Ron
name: Butler, Brian L.
name: Fuchs, Charles S.
name: Ogino, Shuji
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: A remarkable feature of regenerative processes is their ability to halt proliferation once an organ’s structure has been restored. The Wnt signaling pathway is the major driving force for homeostatic self-renewal and regeneration in the mammalian intestine. The mechanisms that counterbalance Wnt-driven proliferation are poorly understood. We demonstrate here that YAP, a protein known for its powerful growth-inducing and oncogenic properties1-2, has an unexpected growth-suppressive function restricting Wnt signals during intestinal regeneration. Transgenic expression of YAP reduces Wnt target gene expression and results in the rapid loss of intestinal crypts. In addition, loss of YAP results in Wnt hypersensitivity during regeneration, leading to hyperplasia, expansion of intestinal stem cells (ISCs) and niche cells, and formation of ectopic crypts and microadenomas. We find that cytoplasmic YAP restricts elevated Wnt signaling independently of the APC/Axin/GSK3β complex partly by limiting the activity of Dishevelled (DVL). DVL signals in the nucleus of ISCs and its forced expression leads to enhanced Wnt signaling in crypts. YAP dampens Wnt signals by restricting DVL nuclear translocation during regenerative growth. Finally, we provide evidence that YAP is silenced in a subset of highly aggressive and undifferentiated human colorectal carcinomas (CRC) and its expression can restrict the growth of CRC xenografts. Collectively, our work describes a novel mechanistic paradigm for how proliferative signals are counterbalanced in regenerating tissues. Additionally, our findings have important implications for the targeting of YAP in human malignancies.
Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic
Creators: name: Wu, Huixian
name: Trapella, Claudio
name: Cherezov, Vadim
name: Katritch, Vsevolod
name: Huang, Xi-Ping
name: Chun, Eugene
name: Vardy, Eyal
name: Roth, Bryan L.
name: Liu, Wei
name: Calo, Girolamo
name: Guerrini, Remo
name: Stevens, Raymond C.
name: Thompson, Aaron A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Members of the Opioid Receptor (OR) family of G protein-coupled receptors (GPCRs) are found throughout the peripheral and central nervous system where they play key roles in nociception and analgesia. Unlike the classical ORs, δ–OR, κ–OR,1 and μ-OR,2 which were delineated by pharmacological criteria in the 1970’s and 1980’s, the nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP, aka ORL-1) was discovered relatively recently via molecular cloning and characterization of an orphan GPCR3. Despite its high sequence similarity (~60%) with ORs, NOP has a strikingly distinct pharmacology4,5. Despite high sequence similarity with classical opioid G protein-coupled receptor subtypes, the nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) has a distinct biological and pharmacological role, featuring activation by the endogenous peptide N/OFQ, and unique selectivity for exogenous ligands. This study reports the crystal structure of human NOP solved in complex with the peptide mimetic antagonist Banyu Compound-24 (C-24), revealing atomic details of ligand-receptor recognition and selectivity. C-24 mimics the first four N-terminal residues of the NOP-selective peptide antagonist UFP-101, a close derivative of N/OFQ, and provides important clues to binding of these peptides. The X-ray structure also reveals substantial conformational differences in the pocket regions between NOP and the “classical” opioid receptors κ (Ref. 1) and μ (Ref. 2), which are likely due to a small number of residues that vary between the two receptors. The NOP/C-24 structure explains the divergent selectivity profile of NOP and provides a new structural template for the design of NOP ligands.
Rural Conditions and Trends
Creators: name: USDA ERS
name: USDA ERS
Publisher: name: Unknown
Year: 1993
Subjects: Community/Rural/Urban Development

description: Overview: Rural and Urban Economies Benefit from Year-End Surge; National Economic Conditions: Growth to Turn Strong in 1994, Inflation Stays Low; National Economy Links to Rural Areas: Service Industries Expected to Dominate 1992-2005; Employment: Rural Employment Grows Moderately Throughout 1993; Unemployment: Rural Unemployment Falls Throughout 1993; The Rural Workforce: Farm Entrepreneurs Depended on Both Farm Self-Employment and Wage and Salary Incomes in 1992, Hired Farmworker Earnings Ranked Near the Bottom of Major Occupation Groups in 1992; Appendix: Data Sources and Definitions; Appendix Tables
(:unas) unassigned
Creators: name: (:Unkn) Unknown
Publisher: name: Universita' degli Studi di Salerno
Year: 2024

description: Analizzando i lavori teatrali delle antologie Teatro 1 e Teatro 2 curate dall’artista fiorentino Eugenio Miccini, e scritte da Ketty La Rocca, Achille Bonito Oliva, Giuliano Scabia, Luciano Ori, Giusi Coppini e altri, lo scopo di questo articolo è quello di apportare nuove prospettive nella vasta ed eterogenea produzione del Nuovo teatro, il teatro sperimentale italiano degli anni Sessanta e Settanta, dimostrando così come ci siano ancora performance, esperimenti, e testi che possono essere studiati per illuminare pratiche e riflessioni di questo vibrante periodo.
description: The aim of this article is to supply other perspectives to the wide and heterogenous productions of Nuovo teatro, the experimental theater that took place in Italy in 1960s and 1970s, analyzing the theatrical works collected in the anthologies Teatro 1 and Teatro 2 edited by the Florentine artist Eugenio Miccini, and written by Ketty La Rocca, Achille Bonito Oliva, Giuliano Scabia, Luciano Ori, Giusi Coppini and others. This research demonstrates that there are still performances, experiments, and texts that can be studied to illustrate practices and reflections of this vibrant period.
Tuning the polarization-induced free hole density in nanowires graded from GaN to AlN
Creators: name: Sarwar, A. T. M. Golam
name: Carnevale, Santino D.
name: Kent, Thomas F.
name: Yang, Fan
name: McComb, David W.
name: Myers, Roberto C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We report a systematic study of p-type polarization induced doping in graded AlGaN nanowire light emitting diodes grown on silicon wafers by plasma-assisted molecular beam epitaxy. The composition gradient in the p-type base is varied in a set of samples from 0.7 %Al/nm to 4.95 %Al/nm corresponding to negative bound polarization charge densities of 2.2x10^18 cm^-3 to 1.6x10^19 cm^-3. Capacitance measurements and energy band modeling reveal that for gradients greater than or equal to 1.30 %Al/nm, the deep donor concentration is negligible and free hole concentrations roughly equal to the bound polarization charge density are achieved up to 1.6x10^19 cm^-3 at a gradient of 4.95 %Al/nm. Accurate grading lengths in the p- and n-side of the pn-junction are extracted from scanning transmission electron microscopy images and are used to support energy band calculation and capacitance modeling. These results demonstrate the robust nature of p-type polarization doping in nanowires and put an upper bound on the magnitude of deep donor compensation.
description: 12 pages of text, 3 tables, and 3 figures
The accessible chromatin landscape of the human genome
Creators: name: Dunn, Douglas
name: Lee, Bum-Kyu
name: Vierstra, Jeff
name: Johnson, Ericka M.
name: Lee, Kristen
name: Humbert, Richard
name: Lotakis, Dimitra
name: Sandstrom, Richard
name: Maurano, Matthew T.
name: Nguyen, Eric D.
name: Johnson, Audra K.
name: John, Sam
name: Boatman, Lisa
name: Frum, Tristan
name: Lajoie, Bryan
name: London, Darin
name: Diegel, Morgan
name: Sheffield, Nathan C.
name: Stergachis, Andrew B.
name: Wang, Hao
name: Neph, Shane
name: Giste, Erika
name: Thurman, Robert E.
name: Canfield, Theresa K.
name: Neri, Fidencio
name: Rynes, Eric
name: Vernot, Benjamin
name: Bates, Daniel
name: Haugen, Eric
name: Ebersol, Abigail K.
name: Garg, Kavita
name: Kutyavin, Tanya
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: DNaseI hypersensitive sites (DHSs) are markers of regulatory DNA and have underpinned the discovery of all classes of cis-regulatory elements including enhancers, promoters, insulators, silencers, and locus control regions. Here we present the first extensive map of human DHSs identified through genome-wide profiling in 125 diverse cell and tissue types. We identify ~2.9 million DHSs that encompass virtually all known experimentally-validated cis-regulatory sequences and expose a vast trove of novel elements, most with highly cell-selective regulation. Annotating these elements using ENCODE data reveals novel relationships between chromatin accessibility, transcription, DNA methylation, and regulatory factor occupancy patterns. We connect ~580,000 distal DHSs with their target promoters, revealing systematic pairing of different classes of distal DHSs and specific promoter types. Patterning of chromatin accessibility at many regulatory regions is choreographed with dozens to hundreds of co-activated elements, and the trans-cellular DNaseI sensitivity pattern at a given region can predict cell type-specific functional behaviors. The DHS landscape shows signatures of recent functional evolutionary constraint. However, the DHS compartment in pluripotent and immortalized cells exhibits higher mutation rates than that in highly differentiated cells, exposing an unexpected link between chromatin accessibility, proliferative potential and patterns of human variation.
Letter from Lee Keatinge to David Walker, Memorandum of Agreement Regarding the Demolition of Buildings 239, 2399, and 252, Fort Sam Houston, Texas
Creators: name: Keatinge, Lee
name: Kochan, Nancy
Publisher: name: Advisory Council on Historic Preservation
Year: 1998
Subjects: subject: JBSA-Sam Houston
valueUri: https://core.tdar.org/browse/geographic-keyword/82532/jbsa-sam-houston
subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: Building 252
valueUri: https://core.tdar.org/browse/other-keyword/146348/building-252
subject: Building 239
valueUri: https://core.tdar.org/browse/other-keyword/146345/building-239
subject: Building 2399
valueUri: https://core.tdar.org/browse/other-keyword/152906/building-2399
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management
subject: Research Design / Data Recovery Plan
valueUri: https://core.tdar.org/browse/investigation-type/9/research-design-data-recovery-plan

description: This letter addresses the Memorandum of Agreement (MOA) regarding the demolition of Building 239, 2399, and 252 which has been accepted by the Advisory Council on Historic Preservation.
Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons
Creators: name: Bridges, Arlene S.
name: Miriyala, Jayalakshmi
name: Huang, Hsien-Sung
name: Philpot, Benjamin D.
name: Dutton, J. Walter
name: Chen, Xin
name: Taylor-Blake, Bonnie
name: Roth, Bryan L.
name: Zylka, Mark J.
name: Jin, Jian
name: Lee, Hyeong-Min
name: King, Ian F.
name: Mabb, Angela M.
name: Sciaky, Noah
name: Allen, John A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Angelman syndrome is a severe neurodevelopmental disorder caused by deletion or mutation of the maternal allele of the ubiquitin protein ligase E3A (Ube3a)1–3. In neurons, the paternal allele of Ube3a is intact but epigenetically silenced4–6, raising the possibility that Angelman syndrome could be treated by activating this silenced allele to restore functional UBE3A protein7,8. Using an unbiased, high-content screen in primary cortical neurons from mice, we identified twelve topoisomerase I inhibitors and four topoisomerase II inhibitors that unsilence the paternal Ube3a allele. These drugs included topotecan, irinotecan, etoposide, and dexrazoxane (ICRF-187). At nanomolar concentrations, topotecan upregulated catalytically active UBE3A in neurons from maternal Ube3a-null mice. Topotecan concomitantly downregulated expression of the Ube3a antisense transcript that overlaps the paternal copy of Ube3a9–11. These results suggest that topotecan unsilences Ube3a in cis by reducing transcription of an imprinted antisense RNA. When administered in vivo, topotecan unsilenced the paternal Ube3a allele in several regions of the nervous system, including neurons in the hippocampus, neocortex, striatum, cerebellum and spinal cord. Paternal expression of Ube3a remained elevated in a subset of spinal cord neurons for at least twelve weeks after cessation of topotecan treatment, suggesting transient topoisomerase inhibition can have enduring effects on gene expression. While potential off-target effects remain to be investigated, our findings suggest a therapeutic strategy for reactivating the functional but dormant allele of Ube3a in patients with Angelman syndrome.
Letter from Michael Grizer to Mark Wolfe, Rehabilitation of Building 128, Fort Sam Houston, Texas
Creators: name: Grizer, Michael J.
Publisher: name: United States Air Force, Joint Base San Antonio
Year: 2013
Subjects: subject: JBSA-Sam Houston
valueUri: https://core.tdar.org/browse/geographic-keyword/82532/jbsa-sam-houston
subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Fort Sam Houston National Historic Landmark District
valueUri: https://core.tdar.org/browse/geographic-keyword/82955/fort-sam-houston-national-historic-landmark-district
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: Non-Domestic Structures
valueUri: https://core.tdar.org/browse/site-type/309/non-domestic-structures
subject: Building 128
valueUri: https://core.tdar.org/browse/other-keyword/146286/building-128
subject: Mess Hall
valueUri: https://core.tdar.org/browse/other-keyword/152872/mess-hall
subject: Artillery Barracks
valueUri: https://core.tdar.org/browse/other-keyword/158715/artillery-barracks
subject: Administrative Facility
valueUri: https://core.tdar.org/browse/other-keyword/158716/administrative-facility
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: Joint Base San Antonio is proposing to issue a Request for Proposal to rehabilitate building 128 for use as an admin facility. Building 128 was constructed in 1905 as a mess hall for the artillery barracks and is a contributing element to the National Historic Landmark District. The building has been used as an admin facility for fifty years or more and will be rehabilitated to serve the needs of the Defense Logistics Agency Energy that currently offices at Port San Antonio.
A pathogenic picornavirus acquires an envelope by hijacking cellular membranes
Creators: name: Lemon, Stanley M.
name: Ping, LiFang
name: Jeong, Sook-Hyang
name: McKnight, Kevin L.
name: Feng, Zongdi
name: Hu, Fengyu
name: Madden, Victoria
name: Hensley, Lucinda
name: Walker, Christopher
name: Lanford, Robert E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Animal viruses are broadly categorized structurally by the presence or absence of an envelope composed of a lipid-bilayer membrane1, attributes that profoundly affect stability, transmission, and immune recognition. Among those lacking an envelope, the Picornaviridae are a large and diverse family of positive-strand RNA viruses that includes hepatitis A virus (HAV), an ancient human pathogen that remains a common cause of enterically-transmitted hepatitis2–4. HAV infects in a stealth-like manner and replicates efficiently in the liver5. Virus-specific antibodies appear only after 3–4 weeks of infection, and typically herald its resolution3,4. Although unexplained mechanistically, both anti-HAV antibody and inactivated whole-virus vaccines prevent disease when administered as late as 2 weeks after exposure6, when virus replication is well established in the liver5. Here, we show that HAV released from cells is cloaked in host-derived membranes, thereby protecting the virion from antibody-mediated neutralization. These enveloped viruses (“eHAV”) resemble exosomes7, small vesicles that are increasingly recognized to play important roles in intercellular communications. They are fully infectious, sensitive to chloroform extraction, and circulate in the blood of infected humans. Their biogenesis is dependent upon host proteins associated with endosomal-sorting complexes required for transport (ESCRT)8, VPS4B and ALIX. While the hijacking of membranes by HAV facilitates escape from neutralizing antibodies and likely promotes virus spread within the liver, anti-capsid antibodies restrict replication following infection with eHAV, suggesting a possible explanation for post-exposure prophylaxis. Membrane hijacking by HAV blurs the classic distinction between “enveloped” and “nonenveloped” viruses, and has broad implications for mechanisms of viral egress from infected cells as well as host immune responses.
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
Creators: name: McDowell, Jenny
name: Maduro, Quino
name: Zhu, Jiang
name: Guan, Xiaobin
name: Roskin, Krishna M.
name: Coleman, Holly
name: Zhang, Zhenhai
name: Brooks, Shelise
name: Liao, Hua-Xin
name: Gao, Feng
name: Legaspi, Richelle
name: Blakesley, Robert
name: Benjamin, Betty
name: Lynch, Rebecca
name: Becker, Jesse
name: Masiello, Cathy
name: Johnson, Taccara
name: Alam, S. Munir
name: Boyd, Scott D.
name: Zhou, Tongqing
name: Maskeri, Baishali
name: Lovett, Sean
name: Fire, Andrew Z.
name: Dekhtyar, Mila
name: Han, Joel
name: Gupta, Jyoti
name: Schramm, Chaim A.
name: Shapiro, Lawrence
name: Ho, Shi-ling
name: Hargrove, April
name: Bouffard, Gerry
name: Gregory, Michael
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Current HIV-1 vaccines elicit strain-specific neutralizing antibodies. However, cross-reactive neutralizing antibodies arise in ~20% of HIV-1-infected individuals, and details of their generation could provide a roadmap for effective vaccination. Here we report the isolation, evolution and structure of a broadly neutralizing antibody from an African donor followed from time of infection. The mature antibody, CH103, neutralized ~55% of HIV-1 isolates, and its co-crystal structure with gp120 revealed a novel loop-based mechanism of CD4-binding site recognition. Virus and antibody gene sequencing revealed concomitant virus evolution and antibody maturation. Notably, the CH103-lineage unmutated common ancestor avidly bound the transmitted/founder HIV-1 envelope glycoprotein, and evolution of antibody neutralization breadth was preceded by extensive viral diversification in and near the CH103 epitope. These data elucidate the viral and antibody evolution leading to induction of a lineage of HIV-1 broadly neutralizing antibodies and provide insights into strategies to elicit similar antibodies via vaccination.
Additional file 2 of Recruitment of general practitioners in China: a scoping review of strategies and challenges
Creators: name: Chen, Shiwei
name: Sam, Xin Hui
name: Soong, Aijia
name: Car, Lorainne Tudor
name: Lian, Siqing
name: Smith, Helen E.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 2.
Comprehensive molecular characterization of clear cell renal cell carcinoma
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Genetic changes underlying clear cell renal cell carcinoma (ccRCC) include alterations in genes controlling cellular oxygen sensing (e.g. VHL) and the maintenance of chromatin states (e.g. PBRM1). We surveyed more than 400 tumors using different genomic platforms and identified 19 significantly mutated genes. The PI3K/Akt pathway was recurrently mutated, suggesting this pathway as a potential therapeutic target. Widespread DNA hypomethylation was associated with mutation of the H3K36 methyltransferase SETD2, and integrative analysis suggested that mutations involving the SWI/SNF chromatin remodeling complex (PBRM1, ARID1A, SMARCA4) could have far-reaching effects on other pathways. Aggressive cancers demonstrated evidence of a metabolic shift, involving down-regulation of genes involved in the TCA cycle, decreased AMPK and PTEN protein levels, up-regulation of the pentose phosphate pathway and the glutamine transporter genes, increased acetyl-CoA carboxylase protein, and altered promoter methylation of miR-21 and GRB10. Remodeling cellular metabolism thus constitutes a recurrent pattern in ccRCC that correlates with tumor stage and severity and offers new views on the opportunities for disease treatment.
Criteria for the use of omics-based predictors in clinical trials: Explanation and elaboration
Creators: name: Tricoli, James V.
name: Eberhard, David A.
name: Polley, Mei-Yin C.
name: Taylor, Jeremy M. G.
name: Simon, Richard M.
name: Mesirov, Jill P.
name: Cavenagh, Margaret M.
name: Williams, P. Mickey
name: Bigbee, William L.
name: Shuman, Deborah J.
name: Conley, Barbara A.
name: Kim, Kelly Y.
name: McShane, Lisa M.
name: Lively, Tracy G.
name: Doroshow, James H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The US National Cancer Institute (NCI), in collaboration with scientists representing multiple areas of expertise relevant to ‘omics’-based test development, has developed a checklist of criteria that can be used to determine the readiness of omics-based tests forguiding patient care in clinical trials. The checklist criteria cover issues relating to specimens, assays, mathematical modelling, clinical trial design, and ethical, legal and regulatory aspects. Funding bodies and journals are encouraged to consider the checklist, which they may find useful for assessing study quality and evidence strength. The checklist will be used to evaluate proposals for NCI-sponsored clinical trials in which omics tests will be used to guide therapy.
Supplementary document for On-fiber high-resolution photonic nanojets via high refractive index dielectrics - 6077354.pdf
Creators: name: Pacheco-Peña, Víctor
name: Aljuaid, Wasem
name: Riley, Joseph
name: Healy, Noel
Publisher: name: Optica Publishing Group
Year: 2022
Subjects: Uncategorized

description: Supplementary Document
Study of the $B_{c}$ ${\to}$ $B_{s}π$ decay with the perturbative QCD approach
Creators: name: Sun, Junfeng
name: Yang, Yueling
name: Lu, Gongru
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The $B_{c}$ ${\to}$ $B_{s}π$ decay is studied with the perturbative QCD approach. Three types of wave functions for $B_{s}$ meson are considered. The transition form factor $F_{0}^{B_{c}{\to}B_{s}}(0)$ and the branching ratio ${\cal B}r(B_{c}{\to}B_{s}π)$ are sensitive to the model of the $B_{s}$ meson wave functions. With appropriate inputs, our estimate on ${\cal B}r(B_{c}{\to}B_{s}π)$ is comparable with the recent LHCb measurement. A clear signal of $B_{c}$ ${\to}$ $B_{s}π$ decay should be easily observed at the Large Hadron Collider.
description: 17 pages, 2 figures, revtex4, accepted by Science China : Physics, Mechanics & Astronomy
Additional file 3 of Recruitment of general practitioners in China: a scoping review of strategies and challenges
Creators: name: Chen, Shiwei
name: Sam, Xin Hui
name: Soong, Aijia
name: Car, Lorainne Tudor
name: Lian, Siqing
name: Smith, Helen E.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 3.
title: Feasibility Studies of Conversion Electron Mossbauer Spectroscopy (CEMS) of Iron-Doped InP
Creators: name: Agyekum, Edward
Publisher: name: Old Dominion University Libraries
Year: 1985

description: An electron detector for conversion electron Mossbauer spectroscopy (CEMS) has been designed and built. Tests have been performed to study the effects on the electron detector resolution with respect to high anode voltage, He/CH4 gas flow rate, and counting rate. These parameters have been optimized to detect the 7.3 keV conversion electrons emitted following resonant absorption of the 14.4 keV source gamma-rays associated with the Mossbauer effect using 57Fe nuclei. CEMS spectra have been obtained using standard 57Fe enriched and natural iron samples. CEMS spectra and Mossbauer transmission spectra have also been obtained for iron-compensated InP (InP:Fe) samples which forms a semi-insulating material that is suitable substrate for device applications. The need for the Fe compensation is due to the fact that InP is always the n-type as grown. Thus, Fe3+ sites in the InP acts as acceptors and hence reduce the conductivity of the n-type InP to acceptable levels. Precipitates of Fe in InP are found to be FeP2 , whereas the sub-stitutional Fe in InP is found to contain high spin Fe3+ and perhaps low spin Fe2+ states.
Distinct extended amygdala circuits for divergent motivational states
Creators: name: Pleil, Kristen E.
name: Sparta, Dennis R.
name: Kash, Thomas L.
name: Ung, Randall L.
name: Stamatakis, Alice M.
name: Jennings, Joshua H.
name: Stuber, Garret D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: SummaryThe comorbidity of anxiety and dysfunctional reward processing in illnesses such as addiction1 and depression2 suggests that common neural circuitry contributes to these disparate neuropsychiatric symptoms. The extended amygdala, including the bed nucleus of the stria terminalis (BNST), modulates fear and anxiety3,4, but also projects to the ventral tegmental area (VTA) 5,6, a region implicated in reward and aversion7–13, thus providing a candidate neural substrate for integrating diverse emotional states. However, the precise functional connectivity between distinct BNST projection neurons and their postsynaptic targets in the VTA, as well as the role of this circuit in controlling motivational states have not been described. Here, we recorded and manipulated the activity of genetically and neurochemically identified VTA-projecting BNST neurons in freely behaving mice. Collectively, aversive stimuli exposure produced heterogeneous firing patterns in VTA-projecting BNST neurons. In contrast, in vivo optically-identified glutamatergic projection neurons displayed a net enhancement of activity to aversive stimuli, whereas the firing rate of identified GABAergic projection neurons was suppressed. Channelrhodopsin-2 (ChR2) assisted circuit mapping revealed that both BNST glutamatergic and GABAergic projections preferentially innervate postsynaptic non-dopaminergic VTA neurons, thus providing a mechanistic framework for in vivo circuit perturbations. In vivo photostimulation of BNST glutamatergic projections resulted in aversive and anxiogenic behavioral phenotypes. In contrast, activation of BNST GABAergic projections produced rewarding and anxiolytic phenotypes, which were also recapitulated by direct inhibition of VTA GABAergic neurons. These data demonstrate that functionally opposing BNST to VTA circuits regulate rewarding and aversive motivational states and may serve as a critical circuit node for bidirectionally normalizing maladaptive behaviors.
The influence of a planktivorous fish on zooplankton assemblages in experimental billabongs
Creators: name: Nielsen, D. L
name: Hillman, T. J
name: Smith, F. J
name: Shiel, R. J
Publisher: name: La Trobe
Year: 2023

description: La Trobe University Faculty of Science, Technology and Engineering Murray Darling Freshwater Research Centre

MDFRC item.

This paper discusses the influence of predation by a planktivorous fish on zooplankton assemblages within experimental billabongs. Results suggest that the presence of a small planktivorous fish in experimental billabongs had only a small influence on the structure of zooplankton assemblages and densities of rotifers. Microcrustacean populations were dominated by juveniles, however there were greater numbers of juveniles when the planktivorous fish were present.