cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
ULTRA-STRUCTURE ANALYSIS OF APOPTOSIS INDUCED BY SILVER NANOPARTICLES IN BREAST CANCER MCF 7 VIA INDEPENDENT mTOR- PATHWAY
Creators: name: Fawziah A. AL-Salmi
Publisher: name: Zenodo
Year: 2023
Subjects: m-TOR, AKT, LC3, Caspase 3, Silver Nanoparticles, Autophagy, Apoptosis, Breast Cancer, Ultra-Structure Analysis

description: Abstract 
The aim of this study is to provide evidence of the ability of silver nanoparticles to induce autophagy-associated apoptosis. In this report, silver nanoparticles exhibited time-dependent cytotoxicity in breast cancer cells. Multiple assays verified that the activity of silver nanoparticles to induce autophagy blocked the autophagic flux at 50μg/ml. Furthermore, Ag-NPs impaired lysosomal function by damaging lysosomal ultrastructures. The results revealed that silver nanoparticles activated apoptosis at 39.2% and arrested the cell cycle at S phase due to an increase in the percentage of cells at S phase of 10 percent as compared with non-treated cells. The rt-Pcr results showed downregulation of LC3, AKT, and mTOR. The LC3 gene is an autophagic gene that regulates the autophagy process. The immunohistochemistry showed weaker AKT, while Caspase 3 showed strong immunochemistry staining. Transmission electron microscopy showed autophagosomes that are considered the benchmark for autophagy studies; the number of double-membrane autophagosomes and single-membrane autolysosomes was obviously observed in Ag-NP-treated MCF-7. Finally, these results indicate that the cytotoxicity of Ag-NPs may involve the autophagic pathway in MCF-7 cells.
Additional file 15 of Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer’s disease
Creators: name: Vandermeulen, Lina
name: Geric, Ivana
name: Fumagalli, Laura
name: Kreir, Mohamed
name: Lu, Ashley
name: Nonneman, Annelies
name: Premereur, Jessie
name: Wolfs, Leen
name: Policarpo, Rafaela
name: Fattorelli, Nicola
name: De Bondt, An
name: Van Den Wyngaert, Ilse
name: Asselbergh, Bob
name: Fiers, Mark
name: De Strooper, Bart
name: d’Ydewalle, Constantin
name: Mancuso, Renzo
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Virology

description: Additional file 15 Supplemental Fig. 4. Microglial differentiation of iPSCs and target expression in cultured microglia.
ПРОИЗВОДИТЕЛЬНОСТЬ ТРУДА КАК ОСНОВА УСКОРЕНИЯ ЦИКЛАЛОГИСТИЧЕСКОЙ СИСТЕМЫ В СТРОИТЕЛЬСТВЕ
Creators: name: ПАХОМОВА АЛЛА ВИКТОРОВНА
name: БАШИРЗАДЕ РАМИЛА РАФАИЛ КЫЗЫ
Publisher: name: Основы экономики, управления и права
Year: 2020
Subjects: ПРОИЗВОДИТЕЛЬНОСТЬ ТРУДА
ЦИКЛ ЛОГИСТИЧЕСКОЙ СИСТЕМЫ
СТРОИТЕЛЬСТВО
ЭФФЕКТИВНОСТЬ ТРУДА
LABOR PRODUCTIVITY
THE CYCLE OF THE LOGISTICS SYSTEM
CONSTRUCTION
LABOR EFFICIENCY

description: В статье рассматриваются теоретико-методологические аспекты сокращения логистического цикла на основе повышения производительности. Раскрываются особенности измерителей производительности, отражающие специфику логистических операций и функций. Проводится анализ общих факторов, влияющих на удлинение цикла, и предлагаются направления соблюдения длительности логистического цикла, как основы конкурентоспособности компании.
Life Course Racism and Depressive Symptoms among Young Black Women
Creators: name: Wegienka, G.
name: Woods-Giscombe, C.L.
name: Baird, D.D.
name: Han, X.
name: Wise, L.A.
name: Vines, A.I.
name: Quist, A.J.L.
Publisher: name: Springer
Year: 2022

description: The objective of this study is to evaluate the life course effects of racism on depressive symptoms in young Black women and to identify particularly sensitive periods. Guided by life-course theory and using logistic regression, we analyzed baseline data on racism frequency and stress from racism at two time periods (before age 20 and during the 20s) and follow-up data (at approximate 20-month intervals) on depressive symptoms (using a modified 11-item Center for Epidemiologic Studies Depression Scale, CES-D) among 1612 Black women participants aged 23–34 years living in Detroit, MI. Of the 1612 women, 65% reported experiencing some racism at baseline, and 36.5% had high depressive symptoms at follow-up. Those who experienced high frequency of racism before age 20 had an increased risk for high depressive symptoms (RR = 1.26, 95% CI: 1.07, 1.46) compared to participants in the low racism frequency group. We observed similar associations for high vs. low stress from racism (RR = 1.30, 95% CI : 1.06, 1.54) and high vs. low combination of racism frequency and stress (RR = 1.38, 95% CI: 1.13, 1.64). These findings did not hold or were weaker when assessing racism during the 20s. Among women who experienced high racism across the two time periods, the risk of high depressive symptoms was higher than those who experienced low racism during both periods (RR = 1.49, 95% CI: 1.14, 1.86). The slightly stronger associations between racism and depressive symptoms in childhood and adolescence than in young adulthood suggest that early life might be a sensitive period for experiencing racism.
A classification of finite quantum kinematics
Creators: name: Tolar, J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: Quantum mechanics in Hilbert spaces of finite dimension $N$ is reviewed from the number theoretic point of view. For composite numbers $N$ possible quantum kinematics are classified on the basis of Mackey's Imprimitivity Theorem for finite Abelian groups. This yields also a classification of finite Weyl-Heisenberg groups and the corresponding finite quantum kinematics. Simple number theory gets involved through the fundamental theorem describing all finite discrete Abelian groups of order $N$ as direct products of cyclic groups, whose orders are powers of not necessarily distinct primes contained in the prime decomposition of $N$. The representation theoretic approach is further compared with the algebraic approach, where the basic object is the corresponding operator algebra. The consideration of fine gradings of this associative algebra then brings a fresh look on the relation between the mathematical formalism and physical realizations of finite quantum systems.
description: Presented at "Symmetries in Science XVI" conference, Bregenz (Austria) 2013
Forschung hat viele Gesichter. Auch dein eigenes – über den Wert autoethnografischer Forschung im Feld der Hochschullehre
Creators: name: Lohner, David
Publisher: name: W. Bertelsmann Verlag
Year: 2023
Subjects: Hochschuldidaktik
Autoethnografie

description: Der vorliegende Beitrag kann als Plädoyer verstanden werden, subjektiven Zugängen im wissenschaftlichen Erkenntnisprozess ihren Wert zuzusprechen, und stellt die Autoethnografie als methodischen Zugang vor, eigenes hochschuldidaktisches Han­deln reflektiert zu analysieren. Durch die Einflechtung von persönlichen Schilderun­gen des Autors zeigt der Beitrag, wie individuelle Erfahrungen und Erzählungen mit wissenschaftlicher Erkenntnis in Einklang gebracht werden können.
Thermodynamics of the formation of sulfuric acid dimers in the binary (H2SO4-H2O) and ternary (H2SO4-H2O-NH3) system
Creators: name: Schmidt, J.
name: Ansmann, A.
name: Bühl, J.
name: Wandinger, U.
Publisher: name: München : European Geopyhsical Union
Year: 2015
Subjects: subject: aerosol formation
subject: air temperature
subject: ammonia
subject: atmospheric pressure
subject: concentration (composition)
subject: evaporation
subject: ionization
subject: sulfuric acid
subject: thermodynamics
subject: troposphere
subject: 550

description: Sulfuric acid is an important gas influencing atmospheric new particle formation (NPF). Both the binary (H2SO4–H2O) system and the ternary system involving ammonia (H2SO4–H2O–NH3) may be important in the free troposphere. An essential step in the nucleation of aerosol particles from gas-phase precursors is the formation of a dimer, so an understanding of the thermodynamics of dimer formation over a wide range of atmospheric conditions is essential to describe NPF. We have used the CLOUD chamber to conduct nucleation experiments for these systems at temperatures from 208 to 248 K. Neutral monomer and dimer concentrations of sulfuric acid were measured using a chemical ionization mass spectrometer (CIMS). From these measurements, dimer evaporation rates in the binary system were derived for temperatures of 208 and 223 K. We compare these results to literature data from a previous study that was conducted at higher temperatures but is in good agreement with the present study. For the ternary system the formation of H2SO4·NH3 is very likely an essential step in the formation of sulfuric acid dimers, which were measured at 210, 223, and 248 K. We estimate the thermodynamic properties (dH and dS) of the H2SO4·NH3 cluster using a simple heuristic model and the measured data. Furthermore, we report the first measurements of large neutral sulfuric acid clusters containing as many as 10 sulfuric acid molecules for the binary system using chemical ionization–atmospheric pressure interface time-of-flight (CI-APi-TOF) mass spectrometry.
Additional file 16 of Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer’s disease
Creators: name: Vandermeulen, Lina
name: Geric, Ivana
name: Fumagalli, Laura
name: Kreir, Mohamed
name: Lu, Ashley
name: Nonneman, Annelies
name: Premereur, Jessie
name: Wolfs, Leen
name: Policarpo, Rafaela
name: Fattorelli, Nicola
name: De Bondt, An
name: Van Den Wyngaert, Ilse
name: Asselbergh, Bob
name: Fiers, Mark
name: De Strooper, Bart
name: d’Ydewalle, Constantin
name: Mancuso, Renzo
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Virology

description: Additional file 16 Supplemental Fig. 5. ASOs are internalized and pharmacologically active in cultured human microglia.
Total dose radiation and annealing responses of the back transistor of Silicon-On-Insulator pMOSFETs
Creators: name: Zhao, Xing
name: Zheng, Zhong-Shan
name: Li, Bin-Hong Li Gao Jian-Tou
name: Yu, Fang
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The total dose radiation and annealing responses of the back transistor of Silicon-On-Insulator (SOI) pMOSFETs have been studied by comparing with those of the back transistor of SOI nMOSFETs fabricated on the same wafer. The transistors were irradiated by 60Co γ-rays with various doses, and the front transistors are biased in a Float-State and Off-State, respectively, during irradiation. The total dose radiation responses of the back transistors are characterized by their threshold voltage shifts. The results show that the total dose radiation response of the back transistor of SOI pMOSFETs, similar to that of SOI nMOSFETs, depends greatly on their bias conditions during irradiation. However, with the Float-State bias, rather than the Off-State bias, the back transistors of SOI pMOSFETs reveal a much higher sensitivity to total dose radiation, which is contrary to those of SOI nMOSFETs. In addition, it is also found that the total dose radiation effect of the back transistor of SOI pMOSFETs irradiated with Off-State bias, as well as that of the SOI nMOSFETs, exhibits an increasing trend as the channel length decreases. The annealing response of the back transistors after irradiation at room temperature without bias, characterized by their threshold voltage shifts, indicates that there is a relatively complex annealing mechanism associated with channel length and type, bias condition during irradiation. In particular, for all the transistors irradiated with Off-State bias, their back transistors show an abnormal annealing effect during early annealing. All the results have been discussed and analyzed in detail by the aid of simulation.
Visual Belief Elicitation Reduces the Incidence of False Discovery
Creators: name: Koonchanok, Ratanond
name: Tawde, Gauri Yatindra
name: Narayanasamy, Gokul Ragunandhan
name: Walimbe, Shalmali
name: Reda, Khairi
Publisher: name: arXiv
Year: 2023
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: Visualization supports exploratory data analysis (EDA), but EDA frequently presents spurious charts, which can mislead people into drawing unwarranted conclusions. We investigate interventions to prevent false discovery from visualized data. We evaluate whether eliciting analyst beliefs helps guard against the over-interpretation of noisy visualizations. In two experiments, we exposed participants to both spurious and 'true' scatterplots, and assessed their ability to infer data-generating models that underlie those samples. Participants who underwent prior belief elicitation made 21% more correct inferences along with 12% fewer false discoveries. This benefit was observed across a variety of sample characteristics, suggesting broad utility to the intervention. However, additional interventions to highlight counterevidence and sample uncertainty did not provide significant advantage. Our findings suggest that lightweight, belief-driven interactions can yield a reliable, if moderate, reduction in false discovery. This work also suggests future directions to improve visual inference and reduce bias. The data and materials for this paper are available at https://osf.io/52u6v/
description: To appear in CHI '23: ACM Conference on Human Factors in Computing Systems
ПЕРСПЕКТИВНЫЕ НАПРАВЛЕНИЯ ГОСУДАРСТВЕННОГО ОБЕСПЕЧЕНИЯ ЭКОНОМИЧЕСКОЙ БЕЗОПАСНОСТИ
Creators: name: ФИЛИППОВ АЛЕКСАНДР СЕРГЕЕВИЧ
name: ФИЛИППОВА ИРИНА АЛЕКСАНДРОВНА
Publisher: name: Основы экономики, управления и права
Year: 2020
Subjects: ЭКОНОМИЧЕСКАЯ БЕЗОПАСНОСТЬ
РОССИЯ
ГОСУДАРСТВЕННОЕ УПРАВЛЕНИЕ
ГОСУДАРСТВО
ЭКОНОМИКА
ОБЩЕСТВО
СТРАТЕГИЯ ЭКОНОМИЧЕСКОЙ БЕЗОПАСНОСТИ
ECONOMIC SECURITY
RUSSIA
STATE ADMINISTRATION
GOVERNMENT
ECONOMY
SOCIETY
STRATEGY OF ECONOMIC SECURITY

description: В данной работе представлены перспективные направления государственного обеспечения экономической безопасности, как государственного института Российской Федерации, определяющего способность экономики поддерживать условия жизнедеятельности общества, населения, каждого гражданина и обеспечивать ресурсами народное хозяйство, отрасли, предприятия и домохозяйства. Статья продолжает цикл публикаций авторов по указанной теме на основе Указа Президента РФ от 13.05.2017 N 208 “О Стратегии экономической безопасности Российской Федерации на период до 2030 года”.
Additional file 17 of Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer’s disease
Creators: name: Vandermeulen, Lina
name: Geric, Ivana
name: Fumagalli, Laura
name: Kreir, Mohamed
name: Lu, Ashley
name: Nonneman, Annelies
name: Premereur, Jessie
name: Wolfs, Leen
name: Policarpo, Rafaela
name: Fattorelli, Nicola
name: De Bondt, An
name: Van Den Wyngaert, Ilse
name: Asselbergh, Bob
name: Fiers, Mark
name: De Strooper, Bart
name: d’Ydewalle, Constantin
name: Mancuso, Renzo
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Virology

description: Additional file 17 Supplemental Fig. 6. Fast ASO internalization dynamics in cultured human microglia.
СОЦИОКОММУНИКАТИВНЫЕ МЕХАНИЗМЫ РЕГУЛИРОВАНИЯ СЕТЕВЫХ КОНФЛИКТОВ
Creators: name: БАНЬКОВСКАЯ ЮЛИЯ ЛЕОНИДОВНА
Publisher: name: Основы экономики, управления и права
Year: 2020
Subjects: СЕТЕВЫЕ КОНФЛИКТ
КОММУНИКАЦИЯ
УРЕГУЛИРОВАНИЕ
СЕТЬ
СТАБИЛИЗАЦИЯ
NETWORK CONFLICT
COMMUNICATION
SETTLEMENT
NETWORK
STABILIZATION

description: Анализ основных средств урегулирования сетевых конфликтов приобретает в современном обществе немалую значимость, ибо является необходимым условием устойчивого развития и функционирования социальной системы. Сетевая коммуникация способствует установлению и сохранению социального порядка, стабилизации общества. Средствами разрешения сетевых конфликтов являются договоренности, консультации, дискуссии, различные формы деятельности третьих лиц, переговоры.
Noncommutative Supergeometry and Quantum Supergroups
Creators: name: de Goursac, Axel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Algebra (math.QA)
subject: Mathematical Physics (math-ph)
subject: Operator Algebras (math.OA)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 16W55, 47B50, 58A50, 17B15, 15A66, 46L65, 16T05, 81T75

description: This is a review of concepts of noncommutative supergeometry - namely Hilbert superspace, C*-superalgebra, quantum supergroup - and corresponding results. In particular, we present applications of noncommutative supergeometry in harmonic analysis of Lie supergroups, non-formal deformation quantization of supermanifolds, quantum field theory on noncommutative spaces; and we give explicit examples such as deformation of flat superspaces, noncommutative supertori, solvable topological quantum supergroups.
description: 12 pages, Proceedings of the 30th International Colloquium on Group Theoretical Methods in Physics (Ghent, July 2014)
A note on boundedness of the Hardy-Littlewood maximal operator on Morrey spaces
Creators: name: Gogatishvili, A.
name: Mustafayev, R. Ch.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: Primary 42B25, Secondary 42B35

description: In this paper we prove that the Hardy-Littlewood maximal operator is bounded on Morrey spaces $\mathcal{M}_{1,λ}(\rn)$, $0 \le \la < n$ for radial, decreasing functions on $\rn$
description: 7 pages
АКТУАЛЬНЫЕ ПРОБЛЕМЫ ФЕДЕРАЛИЗМА В КОНТЕКСТЕ СОВРЕМЕННОГО МИРОПОРЯДКА
Creators: name: ШЕВЧЕНКО ЕКАТЕРИНА БОРИСОВНА
Publisher: name: Основы экономики, управления и права
Year: 2020
Subjects: МЕЖДУНАРОДНЫЕ ОТНОШЕНИЯ
ФЕДЕРАЛИЗМ
МИРОВОЙ ПОРЯДОК
INTERNATIONAL RELATIONS
FEDERALISM
WORLD ORDER

description: В данной статье автор обосновывает ряд проблемных мест, связанных с федерализмом на примере полисферного функционирования Российской Федерации. Представлен ряд позиций, обосновывающих необходимость реновации модели государственного управления в части её соотношения с текущими мировыми тенденциями. Выводы, представленные в статье,способствуют развитию теоретических и практических знаний в части концептуального рассмотрения федерализма. Проблема рассматриваемой тематики заключается, с одной стороны, в соотношении федерализма с другими системами политической действительности, с другой стороны, в той уникальной ситуации, в которой оказалась Российская Федерация в контексте развития истории государственных систем и международных отношений. Последнее указывает на усиление тенденций в поиске уникальных (не типовых) решений, основанных не только на экзистенции, но и связанных с проектной деятельностью, позволяющей взглянуть в будущее.
Surfatron acceleration of the high energy protons in the relativistic jets
Creators: name: Istomin, Ya. N.
name: Gunya, A. A.
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: This paper describes the acceleration of high energies protons captured by electrostatic waves in the frame of jet arising in the area of instability of relativistic jet, where spiral structures are excited. The wave has a spatially heterogeneous structure of $\exp(i k_\parallel z +i m_ϕϕ)$. Protons can be captured in potential wells created by spiral waves, and thereby experience acceleration with a mechanism known as surfatron acceleration. Expressions of the maximum energy ($ E_p \simeq 10^{19} eV $) and the energy spectrum from jet parameters are obtained.
description: 7 pages, 3 figures, regular paper
Pharmacokinetic-based failure of a detergent virucidal for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) nasal infections: A preclinical study and randomized controlled trial
Creators: name: Esther, Charles R.
name: Huang, Li Ching
name: Edwards, Caitlin E.
name: Pickles, Raymond J.
name: Baric, Ralph S.
name: Kimple, Adam J.
name: Kimura, Kyle S.
name: Randell, Scott H.
name: Freeman, Michael H.
name: Wessinger, Bronson C.
name: Von Wahlde, Kate
name: Strickland, Britton A.
name: Turner, Justin H.
name: Mikami, Yu
name: Boucher, Richard C.
name: Kato, Takafumi
name: Bacon, Daniel R.
name: Gupta, Veerain C.
name: Sheng, Quanhu
name: Das, Suman R.
name: Ceppe, Agathe S.
name: Brown, Hunter M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: BACKGROUND: The nose is the portal for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, suggesting the nose as a target for topical antiviral therapies. The purpose of this study was to assess both the in vivo and in vitro efficacy of a detergent-based virucidal agent, Johnson and Johnson's Baby Shampoo (J&J), in SARS-CoV-2-infected subjects. METHODS: Subjects were randomized into three treatment groups: (1) twice daily nasal irrigation with J&J in hypertonic saline, (2) hypertonic saline alone, and (3) no intervention. Complementary in vitro experiments were performed in cultured human nasal epithelia. The primary outcome measure in the clinical trial was change in SARS-CoV-2 viral load over 21 days. Secondary outcomes included symptom scores and change in daily temperature. Outcome measures for in vitro studies included change in viral titers. RESULTS: Seventy-two subjects completed the clinical study (n = 24 per group). Despite demonstrated safety and robust efficacy in in vitro virucidal assays, J&J irrigations had no impact on viral titers or symptom scores in treated subjects relative to controls. Similar findings were observed administering J&J to infected cultured human airway epithelia using protocols mimicking the clinical trial regimen. Additional studies of cultured human nasal epithelia demonstrated that lack of efficacy reflected pharmacokinetic failure, with the most virucidal J&J detergent components rapidly absorbed from nasal surfaces. CONCLUSION: In this randomized clinical trial of subjects with SARS-CoV-2 infection, a topical detergent-based virucidal agent had no effect on viral load or symptom scores. Complementary in vitro studies confirmed a lack of efficacy, reflective of pharmacokinetic failure and rapid absorption from nasal surfaces.
КАК ИЗБЕЖАТЬ ОШИБОК В РАБОТЕ ОТДЕЛА СНАБЖЕНИЯ
Creators: name: ЛУЦЕНКО ИГОРЬ ВИКТОРОВИЧ
Publisher: name: Основы экономики, управления и права
Year: 2020
Subjects: ОТДЕЛ СНАБЖЕНИЯ
СПЕЦИАЛИСТ ПО ЗАКУПКАМ
ДЕНЕЖНЫЕ СРЕДСТВА
ОШИБКИ В РАБОТЕ
ЗАКАЗЧИК
ПОСТАВЩИК
SUPPLY DEPARTMENT
PURCHASING SPECIALIST
CASH
ERRORS IN WORK
CUSTOMER
SUPPLIER

description: Эффективность работы специалистов по закупкам в любой компании имеет огромное значение, поскольку деятельность отдела снабжения может привести как к максимальной экономии денежных средств, так и к перерасходу финансов компании. Необходимо понимать, что компания должна восприниматься как единое целое - с правильной работой всех отделов, которые полноценно и качественно выполняют свою задачу по аналогии с живым организмом. В данной статье автор рассматривает наиболее распространенные и не так часто встречающиеся ошибки специалистов по закупкам и способы их предотвращения.
Additional file 18 of Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer’s disease
Creators: name: Vandermeulen, Lina
name: Geric, Ivana
name: Fumagalli, Laura
name: Kreir, Mohamed
name: Lu, Ashley
name: Nonneman, Annelies
name: Premereur, Jessie
name: Wolfs, Leen
name: Policarpo, Rafaela
name: Fattorelli, Nicola
name: De Bondt, An
name: Van Den Wyngaert, Ilse
name: Asselbergh, Bob
name: Fiers, Mark
name: De Strooper, Bart
name: d’Ydewalle, Constantin
name: Mancuso, Renzo
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Virology

description: Additional file 18 Supplemental Fig. 7. Cellular and secreted APOE protein levels in cultured human isogenic gene-edited APOE microglia.
Group Theory for Embedded Random Matrix Ensembles
Creators: name: Kota, V. K. B.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mathematical Physics (math-ph)
subject: Chaotic Dynamics (nlin.CD)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Embedded random matrix ensembles are generic models for describing statistical properties of finite isolated quantum many-particle systems. For the simplest spinless fermion (or boson) systems with say $m$ fermions (or bosons) in $N$ single particle states and interacting with say $k$-body interactions, we have EGUE($k$) [embedded GUE of $k$-body interactions) with GUE embedding and the embedding algebra is $U(N)$. In this paper, using EGUE($k$) representation for a Hamiltonian that is $k$-body and an independent EGUE($t$) representation for a transition operator that is $t$-body and employing the embedding $U(N)$ algebra, finite-$N$ formulas for moments up to order four are derived, for the first time, for the transition strength densities (transition strengths multiplied by the density of states at the initial and final energies). In the asymptotic limit, these formulas reduce to those derived for the EGOE version and establish that in general bivariate transition strength densities take bivariate Gaussian form for isolated finite quantum systems. Extension of these results for other types of transition operators and EGUE ensembles with further symmetries are discussed.
description: J. Phys.: Conf. Ser. in press (Proceedings of the 30th International Colloquium on `Group Theoretical Methods in Physics' held at Ghent University, Belgium, during 14-18 July 2014)
Strong aerosol-cloud interaction in altocumulus during updraft periods: Lidar observations over central Europe
Creators: name: Schmidt, J.
name: Ansmann, A.
name: Bühl, J.
name: Wandinger, U.
Publisher: name: München : European Geopyhsical Union
Year: 2015
Subjects: subject: aerosol cloud droplet
subject: cumulus
subject: entrainment
subject: lidar
subject: remote sensing
subject: statistical analysis
subject: turbulent mixing
subject: 550

description: For the first time, a liquid-water cloud study of the aerosol–cloud-dynamics relationship, solely based on lidar, was conducted. Twenty-nine cases of pure liquid-water altocumulus layers were observed with a novel dual-field-of-view Raman lidar over the polluted central European site of Leipzig, Germany, between September 2010 and September 2012. By means of the novel Raman lidar technique, cloud properties such as the droplet effective radius and cloud droplet number concentration (CDNC) in the lower part of altocumulus layers are obtained. The conventional aerosol Raman lidar technique provides the aerosol extinction coefficient (used as aerosol proxy) below cloud base. A collocated Doppler lidar measures the vertical velocity at cloud base and thus updraft and downdraft occurrence. Here, we present the key results of our statistical analysis of the 2010–2012 observations. Besides a clear aerosol effect on cloud droplet number concentration in the lower part of the altocumulus layers during updraft periods, turbulent mixing and entrainment of dry air is assumed to be the main reason for the found weak correlation between aerosol proxy and CDNC higher up in the cloud. The corresponding aerosol–cloud interaction parameter based on changes in cloud droplet number concentration with aerosol loading was found to be close to 0.8 at 30–70 m above cloud base during updraft periods and below 0.4 when ignoring vertical-wind information in the analysis. Our findings are extensively compared with literature values and agree well with airborne observations.
Potential of volatile organic compounds as markers of entrapped humans for use in urban search-and-rescue operations
Creators: name: Mochalski, Pawel
name: Unterkofler, Karl
name: Teschl, Gerald
name: Amann, Anton
Publisher: name: arXiv
Year: 2015
Subjects: subject: Other Quantitative Biology (q-bio.OT)
subject: FOS: Biological sciences

description: Volatile organic compounds emitted by a human body form a chemical signature capable of providing invaluable information on the physiological status of an individual and, thereby, could serve as signs-of-life for detecting victims after natural or man-made disasters. In this review a database of potential biomarkers of human presence was created on the basis of existing literature reports on volatiles in human breath, skin emanation, blood, and urine. Approximate fluxes of these species from the human body were estimated and used to predict their concentrations in the vicinity of victims. The proposed markers were classified into groups of different potential for victim detection. The major classification discriminants were the capability of detection by portable, real-time analytical instruments and background levels in urban environment. The data summarized in this review are intended to assist studies on the detection of humans via chemical analysis and accelerate investigations in this area of knowledge.
description: 38 pages
АНАЛИЗ ПРОГРАММЫ ИМПОРТОЗАМЕЩЕНИЯ НА РОССИЙСКОМ ФАРМАЦЕВТИЧЕСКОМ РЫНКЕ
Creators: name: ГЕРАСИМОВ КИРИЛЛ БОРИСОВИЧ
name: СЕРЕДАВИНА ЯНА ИВАНОВНА
Publisher: name: Основы экономики, управления и права
Year: 2020
Subjects: ИМПОРТОЗАМЕЩЕНИЕ
ФАРМАЦЕВТИЧЕСКИЙ РЫНОК
ПРОИЗВОДСТВО
ФАРМАЦЕВТИЧЕСКАЯ ПРОДУКЦИЯ
ФАРМАЦЕВТИЧЕСКИЙ КЛАСТЕР
IMPORT
IMPORT SUBSTITUTION
PHARMACEUTICAL MARKET
MANUFACTURING
PHARMACEUTICAL PRODUCTS
PHARMACEUTICAL CLUSTERS

description: В данной статье рассмотрена реализация программы импортозамещения лекарственных препаратов на российском фармацевтическом рынке. Проведен анализ динамики и структуры данного отраслевого рынка за последние 4 года. Особое внимание в структуре уделено коммерческому сегменту фармацевтического рынка. Детализировано соотношение отечественных и импортных лекарственных препаратов. Также отмечена динамика импорта фармацевтических субстанций. В ходе исследования выявлено, что производство собственных фармацевтических субстанций на базе фармацевтических кластеров на данный момент является перспективным направлением реализации программы импортозамещения.
Subsite Ligand Recognition and Cooperativity in the TPP Riboswitch: Implications for Fragment-Linking in RNA Ligand Discovery
Creators: name: Zeller, M.J.
name: Nuthanakanti, A.
name: Serganov, A.
name: Aubé, J.
name: Li, K.
name: Weeks, K.M.
Publisher: name: American Chemical Society
Year: 2022

description: RNA molecules can show high levels of cooperativity in their global folding and interactions with divalent ions. However, cooperativity at individual ligand-RNA interaction sites remains poorly understood. Here, we investigated the binding of thiamine and methylene diphosphonic acid (MDP, a soluble structural analogue of pyrophosphate) to the thiamine pyrophosphate riboswitch. These ligands each bind weakly at proximal subsites, with 10 μM and 1 mM affinities, respectively. The affinity of MDP moderately improves when thiamine or thiamine-like fragments are pre-bound to the RNA. Covalent linking of thiamine and MDP substantially increases riboswitch binding to a notable high affinity of 20 nM. Crystal structures and single-molecule correlated chemical probing revealed favorable induced fit effects upon binding of individual ligands and, unexpectedly, a substantial thermodynamically unfavorable RNA structural rearrangement upon binding of the linked thiamine-MDP ligand. Thus, linking of two ligands of modest affinity, accompanied by an unfavorable structural rearrangement, still yields a potent linked RNA-binding compound. Since complex ligands often bind riboswitches and other RNAs at proximal subsites, principles derived from this work inform and support fragment-linking strategies for identifying small molecules that interact with RNA specifically and with high affinity.
MSG: A software package for interpolating stellar spectra in pre-calculated grids
Creators: name: Townsend, Rich
name: Lopez, Aaron
Publisher: name: arXiv
Year: 2023
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: While the spectrum of the light emitted by a star can be calculated by simulating the flow of radiation through each layer of the star's atmosphere, this process is computationally expensive. Therefore, it is often far more efficient to pre-calculate spectra over a grid of photospheric parameters, and then interpolate within this grid. MSG (short for Multidimensional Spectral Grids) is a software package that implements this interpolation capability.
description: Repository at https://github.com/rhdtownsend/msg , documentation at https://msg.readthedocs.io/en/stable/
Complex Langevin and other approaches to the sign problem in quantum many-body physics
Creators: name: Ehmann, F.
name: Berger, C.E.
name: Rammelmüller, L.
name: Loheac, A.C.
name: Braun, J.
name: Drut, J.E.
Publisher: name: Elsevier B.V.
Year: 2021

description: We review the theory and applications of complex stochastic quantization to the quantum many-body problem. Along the way, we present a brief overview of a number of ideas that either ameliorate or in some cases altogether solve the sign problem, including the classic reweighting method, alternative Hubbard–Stratonovich transformations, dual variables (for bosons and fermions), Majorana fermions, density-of-states methods, imaginary asymmetry approaches, and Lefschetz thimbles. We discuss some aspects of the mathematical underpinnings of conventional stochastic quantization, provide a few pedagogical examples, and summarize open challenges and practical solutions for the complex case. Finally, we review the recent applications of complex Langevin to quantum field theory in relativistic and nonrelativistic quantum matter, with an emphasis on the nonrelativistic case.
Doping dependence of the critical current in Bi2Sr2CaCu2Oy
Creators: name: Naamneh, Muntaser
name: Campuzano, Juan Carlos
name: Kanigel, Amit
Publisher: name: arXiv
Year: 2014
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: The doping dependence of the critical current density, $J_{c}$, was measured in a series of high quality c-axis oriented ${\rm Bi_2Sr_2CaCu_2O_{8+δ}}$ thin films. For each doping level we measured the temperature dependence of $J_{c}$. We find that all samples have the same temperature dependence, but the critical current at zero temperature, $J_{c}(0)$, has a non-trivial doping dependence with a maximum at a unique doping level in the overdoped side of the superconducting dome.
title:  Da violência contra si: a autodestruição por meio do suicídio no meio rural no Rio Grande do Sul/Brasil
Creators: name: Mendes, Jussara Maria Rosa
name: Werlang, Rosangela
Publisher: name: Roma TrE-Press
Year: 2015

description: Este texto trata da questão do suicídio no Rio Grande do Sul/Brasil, considerando o contexto do avanço do capitalismo no campo. Este avanço tem propiciado novos modos e estilos de vida que, por seu turno, tem favorecido a algumas sociopatologias, dentre estas, a autodestruição por meio do suicídio. Das violências a que estamos expostos todos os dias, a violência contra si é uma das mais graves, vez que denuncia a sociedade deletéria em que se vive, assim como seus pontos de desagregação. Neste sentido, aponta a investida do capital para que se consolide o fim da pequena agricultura tradicional, seja por meio da articulação com a indústria e seus métodos perversos de gestão, seja por meio da pluriatividade, expressão contemporânea da flexibilização e, ademais, da precarização do trabalho no meio rural.
description: KRYPTON – VOL.5/6 – 2015 – VIOLENZA
Additional file 19 of Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer’s disease
Creators: name: Vandermeulen, Lina
name: Geric, Ivana
name: Fumagalli, Laura
name: Kreir, Mohamed
name: Lu, Ashley
name: Nonneman, Annelies
name: Premereur, Jessie
name: Wolfs, Leen
name: Policarpo, Rafaela
name: Fattorelli, Nicola
name: De Bondt, An
name: Van Den Wyngaert, Ilse
name: Asselbergh, Bob
name: Fiers, Mark
name: De Strooper, Bart
name: d’Ydewalle, Constantin
name: Mancuso, Renzo
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Virology

description: Additional file 19 Supplemental Fig. 8. ASOs are internalized and pharmacologically active in H9 hESC-derived microglia.
Household Financial Capability and Economic Hardship: An Empirical Examination of the Financial Capability Framework
Creators: name: Chen, Y.-C.
name: Ansong, D.
name: Sherraden, M.S.
name: Huang, J.
name: Sun, S.
Publisher: name: Springer
Year: 2022

description: This study investigates the components and mechanisms of the financial capability framework using national representative data from the 2015 National Financial Capability Study with the structural equation modeling approach. We find financial socialization and financial education are significantly associated with both financial access and financial literacy, which are associated with positive financial behavior and negatively associated with economic hardship. We further find that financial access plays a more pronounced role in the mediation effects decomposition compared to financial literacy. Our findings demonstrate that financial capability lies in both the opportunity to act and the ability to act—with opportunity relatively more important than ability—and that financial capability is strongly associated with household experiences of economic hardship. Policies and programs should provide accessible and affordable financial products as well as enhance effective financial education and guidance to promote financial inclusion.
Advances in QCD sum rule calculations
Creators: name: Melikhov, Dmitri
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We review the recent progress in the applications of QCD sum rules to hadron properties with the emphasis on the following selected problems: (i) development of new algorithms for the extraction of ground-state parameters from two-point correlators; (ii) form factors at large momentum transfers from three-point vacuum correlation functions; (iii) properties of exotic tetraquark hadrons from correlation functions of four-quark currents.
description: 12 pages, plenary talk given at the XIth International Conference on Quark Confinement and the Hadron Spectrum, Saint Petersburg, Russia, September 8-12, 2014
Dave De ruysscher, Albrecht Cordes, Serge Dauchy, Stefania Gialdroni, Heikki Pihlajamäki (ed.), Commerce, Citizenship, and Identity in Legal History, Leiden (Brill Academic Publishers) 2022
Creators: name: Hellwege, Phillip
Publisher: name: Francia-Recensio
Year: 2023

description: Dave De ruysscher, Albrecht Cordes, Serge Dauchy, Stefania Gialdroni, Heikki Pihlajamäki (ed.), Commerce, Citizenship, and Identity in Legal History, Leiden (Brill Academic Publishers) 2022, IX–220 p. (Legal History Library, 54), ISBN 978-90-04-47285-3, EUR 105,00.
description: Francia-Recensio, 2023/1
КРИТЕРИИ ОЦЕНКИ ЭФФЕКТИВНОСТИ СИСТЕМЫ СТРАТЕГИЧЕСКОГО УПРАВЛЕНИЯ ПРОЕКТАМИ НА ПРЕДПРИЯТИИ НЕФТЕГАЗОВОГО ПРОФИЛЯ
Creators: name: ЕРМОЛИНА ЛИЛИЯ ВАЛЕРЬЕВНА
name: СКВОРЦОВА АСТИЛЬДА АНДРЕЕВНА
Publisher: name: Основы экономики, управления и права
Year: 2020
Subjects: СТРАТЕГИЧЕСКОЕ УПРАВЛЕНИЕ
ПРОЕКТНОЕ УПРАВЛЕНИЕ
РАЗВИТИЕ ПРЕДПРИЯТИЯ
СИСТЕМА УПРАВЛЕНИЯ
МЕТОД СТУПЕНЕК
OIL PRODUCTION
STRATEGIC PLANNING
OIL PRODUCTION RISKS
METHODOLOGY
ASSESSMENT

description: Данная статья посвящена анализу актуальности разработки системы стратегического управления проектами в компании. Определены основные факторы, характеризующие процесс создания и развития предприятия. Отмечено, что для создания более эффективной системы управления проектом целесообразно использовать стратегический подход и целесообразно представить этапы развития предприятия в виде модели жизненного цикла проекта. Приведены направления стратегии управления проектами с учетом «ступенек» развития компании.
Additional file 20 of Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer’s disease
Creators: name: Vandermeulen, Lina
name: Geric, Ivana
name: Fumagalli, Laura
name: Kreir, Mohamed
name: Lu, Ashley
name: Nonneman, Annelies
name: Premereur, Jessie
name: Wolfs, Leen
name: Policarpo, Rafaela
name: Fattorelli, Nicola
name: De Bondt, An
name: Van Den Wyngaert, Ilse
name: Asselbergh, Bob
name: Fiers, Mark
name: De Strooper, Bart
name: d’Ydewalle, Constantin
name: Mancuso, Renzo
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Virology

description: Additional file 20 Supplemental Fig. 9. ASO is widely distributed in the brain 7 days after icv ASO administration.
An exploration of what stakeholders reveal about personality traits and associated behaviours of registered nurses working in older people’s acute care settings
Creators: name: Day, Helen
Publisher: name: London South Bank University
Year: 2020

description: Background Concern around poor standards of nursing care for older people in hospital has been explored in relation to workload and operational pressures. What is less evident from existing literature in this field is an explanation as to why nurses behave differently under the same pressures within the same concrete situations. Notions of personality traits and associated behaviours as possible influencers on nursing care delivery are variables that require consideration. Aim To critically explore behaviours of registered nursing staff working in older people's acute care settings from perspectives gathered from key stakeholders, and to identify whether there are any distinguishing personality traits that influence effective care delivery for older people. Methodology Using a constructivist grounded theory methodology, semi structured interviews were conducted to gather data from 12 stakeholder participants. Representation was from patient governors, carers and others from a nursing or relevant professional background. Data was analysed through a process of initial, focussed and finally theoretical coding. Findings Analysis of data gathered from stakeholders identified a rubric, describing specific behaviours aligned with associated trait headings. A range of behaviours were identified spanning between two distinct types of nursing staff. One group of nurses who work with older people are perceived to have no real desire to do so and in turn their care behaviours are perceived as ‘cold’ and task based. A second group of nurses are perceived as having a commitment to older people’s wellbeing and their behaviours lead to the delivery of care that is perceived as being highly skilled and compassionate. A theoretical framework was constructed from this data analysis that identifies four key personality traits related to nursing behaviours. These are referred to as: conscientiousness, sociability, integrity and coping under a core category heading of ‘the authentic self’. Whilst authentic self is identified as being a direct influencer on how care is delivered, defined as the consequence, the influence of context is also taken into account. Conclusion This research offers new insights into four key personality traits and associated behavious displayed by nurses working in the acute older people’s healthcare setting and what effect these behaviours have on nursing care delivery, derived from perspectives of various older people’s nursing key stakeholders. Implications for healthcare practice are presented, which includes potential for further research that can inform the development of educational and recruitment strategies for older people’s nurses. This will ultimately have a positive impact on the quality of care older patients can expect to receive when in hospital.
Multi-wavelength Emission from the Fermi Bubble II. Secondary Electrons and the Hadronic Model of the Bubble
Creators: name: Cheng, K. -S.
name: Chernyshov, D. O.
name: Dogiel, V. A.
name: Ko, C. -M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We analyse the origin of the gamma-ray flux from the Fermi Bubbles (FBs) in the framework of the hadronic model in which gamma-rays are produced by collisions of relativistic protons with the protons of background plasma in the Galactic halo. It is assumed in this model that the observed radio emission from the FBs is due to synchrotron radiation of secondary electrons produced by $pp$ collisions. However, if these electrons loose their energy by the synchrotron and inverse-Compton, the spectrum of secondary electrons is too soft, and an additional arbitrary component of primary electrons is necessary in order to reproduce the radio data. Thus, a mixture of the hadronic and leptonic models is required for the observed radio flux. It was shown that if the spectrum of primary electrons is $\propto E_e^{-2}$, the permitted range of the magnetic field strength is within 2 - 7 $μ$G region. The fraction of gamma-rays produced by $pp$ collisions can reach about 80% of the total gamma-ray flux from the FBs. If magnetic field is <2 $μ$G or >7 $μ$G the model is unable to reproduce the data. Alternatively, the electrons in the FBs may lose their energy by adiabatic energy losses if there is a strong plasma outflow in the GC. Then, the pure hadronic model is able to reproduce characteristics of the radio and gamma-ray flux from the FBs. However, in this case the required magnetic field strength in the FBs and the power of CR sources are much higher than those followed from observations.
description: 18 pages, 4 figures. Accepted for publication in ApJ