Additional file 1 of Markers of kidney function, genetic variation related to cognitive function, and cognitive performance in the UK Biobank
Creators: name: Richard, Erin L.
name: McEvoy, Linda K.
name: Deary, Ian J.
name: Davies, Gail
name: Cao, Steven Y.
name: Oren, Eyal
name: Alcaraz, John E.
name: LaCroix, Andrea Z.
name: Bressler, Jan
name: Salem, Rany M.
Publisher: name: figshare
Year: 2022
Subjects: subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Fig S1. Histograms showing propensity score distributions between unmatched and matched samples for (a) eGFRcre&lt;60ml/min, (b) eGFRcys&lt;60ml/min and (c) albuminuria in individuals who completed the verbal-numeric reasoning test. Treatment refers to case status (0=control, 1=case). Fig S2. Histograms showing propensity score distributions between unmatched and matched samples for (a) eGFRcre&lt;60ml/min, (b) eGFRcys&lt;60ml/min and (c) albuminuria in individuals who completed the reaction time test. Treatment refers to case status (0=control, 1=case). Fig S3. Histograms showing propensity score distributions between unmatched and matched samples for (a) eGFRcre&lt;60ml/min, (b) eGFRcys&lt;60ml/min and (c) albuminuria in individuals who completed the visual memory test. Treatment refers to case status (0=control, 1=case). Fig S4. Proportional Venn diagram illustrating the degree of overlap between individuals with eGFRcys&lt;60 eGFRcre&lt;60 and albuminuria. Created using BioVenn web application [73]. Fig. S5. Predicted mean reaction time and 95% confidence intervals using eGFRcys category as a predictor grouped by age category. Abbreviations: eGFRcys, cystatin C-based estimated glomerular filtration rate. Fig. S6. Differences in cognitive performance on the (a) reaction time test expressed as age year equivalents and (b) the verbal-numeric reasoning test expressed as education year equivalents according to albuminuria, eGFRcys&lt;60, and eGFRcre&lt;60. For reaction time tests, values are based on the ratio of the coefficients for albuminuria, eGFRcys&lt;60, or eGFRcys&lt;60 and cross-sectional coefficients for years of age. For verbal-numeric tests, values are based on the ratio of the coefficients for albuminuria, eGFRcys&lt;60, or eGFRcre&lt;60 and cross-sectional coefficients for years of education. Table S1. Characteristics of participants with and without verbal-numeric reasoning scores. Table S2.Cardiovascular disease variable definitions. Table S3. Characteristics of study population according to albuminuria status: the UK Biobank. Table S4. Characteristics of study population according to eGFRcre category. Table S5. Characteristics of study population according to eGFRcys category. Table S6.Multivariable linear regression analyses of association between kidney marker exposure categories and cognitive performance. Table S7.Multivariable linear regression analyses of association between kidney marker exposure categories and cognitive performance adjusted for cardiovascular disease. Table S8.Multivariable linear regression analyses of associations between albuminuria, cognitive function polygenic score and cognitive performance. Table S9.Multivariable linear regression analyses of association between kidney marker exposure categories and cognitive performance excluding those with type II diabetes. Table S10.Multivariable linear regression analyses of association between kidney marker exposure categories and cognitive performance excluding those with past stroke. Table S11.Multivariable linear regression analyses of association between kidney marker exposure categories and cognitive performance adjusting for age2. Table S12.Multivariable linear regression analyses of association between kidney marker exposure categories and cognitive performance adjusting for whole-body fat free mass.