cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Substructure in Clusters and Central Galaxy Peculiar Velocities
Creators: name: Bird, Christina M.
Publisher: name: arXiv
Year: 1994
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Formation theories for central dominant galaxies in clusters require them to be located at the minimum of the cluster gravitational potential. However, 32\% (8 out of 25) of the clusters with more than 50 measured redshifts have central galaxies with significant velocity offsets (with respect to other cluster members). By studying their velocity distributions and correlations between velocity and position, I show that the presence of a large peculiar velocity is strongly correlated with the presence of substructure in these massive systems. About 85\% (21 of 25) of all well-studied clusters show some evidence for substructure, in contrast to the 30-40\% found when using only galaxy or gas distributions. The correlation between substructure and central galaxy location verifies the hypothesis of Merritt (1985) and Tremaine (1990) that high peculiar velocities are indicative of recent merger events between less-massive systems of galaxies. Dynamical friction should act quickly to pull the central galaxy, the most massive discrete object in a cluster, to the minimum of the potential. The less-massive galaxies retain information about their primordial subclusters for a longer period of time. I use an objective partitioning algorithm to assign cluster galaxies to their host subclumps. When galaxies are allocated in this fashion to their subclusters, 75\% of the significant velocity offsets are eliminated. Only 2 out of the 25 clusters have central galaxies which are not centrally-located when substructure is considered in the analysis.
description: 40 pages (text, figures and tables)
Teleparallel Palatini theories
Creators: name: Jimenez, Jose Beltran
name: Heisenberg, Lavinia
name: Koivisto, Tomi
Publisher: name: arXiv
Year: 2018
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The Palatini formalism is developed for gravitational theories in flat geometries. We focus on two particularly interesting scenarios. First, we fix the connection to be metric compatible, but we follow a completely covariant approach by imposing the constraints with suitable Lagrange multipliers. For a general quadratic theory we show how torsion naturally propagates and we reproduce the Teleparallel Equivalent of General Relativity as a particular quadratic action that features an additional Lorentz symmetry. We then study the much less explored theories formulated in a geometry with neither curvature nor torsion, so that all the geometrical information is encoded in the non-metricity. We discuss how this geometrical framework leads to a purely inertial connection that can thus be completely removed by a coordinate gauge choice, the coincident gauge. From the quadratic theory we recover a simpler formulation of General Relativity in the form of the Einstein action, which enjoys an enhanced symmetry that reduces to a second linearised diffeomorphism at linear order. More general theories in both geometries can be formulated consistently by taking into account the inertial connection and the associated additional degrees of freedom. As immediate applications, the new cosmological equations and their Newtonian limit are considered, where the role of the lapse in the consistency of the equations is clarified, and the Schwarzschild black hole entropy is computed by evaluating the corresponding Euclidean action. We discuss how the boundary terms in the usual formulation of General Relativity are related to different choices of coordinates in its coincident version and show that in isotropic coordinates the Euclidean action is finite without the need to introduce boundary or normalisation terms.
description: 27 pages, accompanying paper to arXiv:1710.03116
Modified host defence peptides as beta-lactamase-dependent antibiotic prodrug candidates.
Creators: name: Stephane Desgranges
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Infections caused by antibiotic resistant bacteria have been listed as top priority diseases by the World Health Organisation (WHO) in terms of their threat to global public health if the need for novel medicines is not met. Host defence peptides (HDPs) are multifunctional molecular effectors of innate immunity, the first line of defence against infection in multicellular organisms. They are characterised by an antimicrobial activity essentially directed at a universal non-protein target (bacterial membrane(s)), complemented by multiple immunomodulatory and anti-inflammatory activities. They are recognised as promising candidates for the development of novel antimicrobial and anti-inflammatory agents, owing to their original and selective mode of action which may circumvent the limitations of classical antibiotics in terms of drug resistance. Despite their potential in medicine, these 'Nature's antibiotics' have not yet been approved for use as drugs. Their main limitations are a risk of unpredictable side-effects when administered systemically and a lack of stability limiting their efficacy. Several approaches have been proposed to achieve clinical success with host defence peptides, such as conversion into peptidomimetics, liposomal delivery and a prodrug strategy. Prodrugs are pharmacologically inactive molecules metabolised to an active agent. Ideally this metabolic step is catalysed by an enzyme confined to a targeted body site andlor associated with a pathological process. Despite the potential of this approach, no inactive precursors of host defence peptides eligible for disease site specific activation have been reported to date. The present project aimed at developing prodrugs of host defence peptides by conjugating selected candidates to a p-lactam molecule (cephalosporin) as a promoiety. These components are joined by a linker which can release the peptide upon degradation of the cephalosporin by a p-lactamase (elimination promoted-immolative carbamate linker). The technology required to unequivocally and efficiently conjugate a peptide to a cephalosporin has been developed and applied to the successful preparation of P-lactamase-dependent prodrug candidates of host defence peptides, the fmt to be reported for these mediators of innate immunity.
Quantum Measurement, Gravitation, and Locality
Creators: name: Ahluwalia, D. V.
Publisher: name: arXiv
Year: 1993
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: This essay argues that when measurement processes involve energies of the order of the Planck scale, the fundamental assumption of locality may no longer be a good approximation. Idealized position measurements of two distinguishable spin-$0$ particles are considered. The measurements alter the space-time metric in a fundamental manner governed by the commutation relations $[x_i\,\,p_j]= i\hbar\,δ_{ij}$ and the classical field equations of gravitation. This {\it in-principle} unavoidable change in the space-time metric destroys the commutativity (and hence locality) of position measurement operators.
description: LA-UR-93-2890-REV, "honorable mention" for the 1994 Awards by Gravity Research Foundation
USG COVID-19 Response Team / CoVPN Vaccine Efficacy Trial Immune Correlates Statistical Analysis Plan
Creators: name: Team, USG COVID-19 Response Team / Coronavirus Prevention Network (CoVPN) Biostatistics
name: Gilbert, Peter B.
name: Fong, Youyi
name: Benkeser, David
name: Andriesen, Jessica
name: Borate, Bhavesh
name: Carone, Marco
name: Carpp, Lindsay N.
name: Diaz, Ivan
name: Fay, Michael P.
name: Fiore-Gartland, Andrew
name: Hejazi, Nima S.
name: Huang, Ying
name: Huang, Yunda
name: Hyrien, Ollivier
name: Janes, Holly E.
name: Juraska, Michal
name: Li, Kendrick
name: Luedtke, Alex
name: Nason, Martha
name: Randhawa, April K.
name: van der Laan, Lars
name: Williamson, Brian
name: Zhang, Wenbo
name: Follmann, Dean
Publisher: name: figshare
Year: 2021
Subjects: subject: 10402 Biostatistics
subject: FOS: Mathematics
subject: Immunology
subject: FOS: Clinical medicine
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Medicine
subject: 110399 Clinical Sciences not elsewhere classified
subject: Diseases

description: This Statistical Analysis Plan (SAP) describes the statistical analysis of antibody markers measured at a key time point post last vaccination as correlates of risk and as various types of correlates of protection against primary and secondary endpoints in COVID-19 Prevention Network (CoVPN) COVID-19 vaccine efficacy (VE) trials.
title: UMass ADVANCE STEM Caregiving and Gender Findings 2022
Creators: name: Liu, Shuyin
name: Misra, Joya
name: Smith-Doerr, Laurel
Publisher: name: University of Massachusetts Amherst
Year: 2023

description: In this research brief, we describe some of the key findings from this survey, focusing on patterns among STEM faculty by gender and caregiving status. We explore whether and how the intersection of gender and caregiving status affect STEM faculty inclusion, shared decision-making, and research collaboration.
Search for OH 18-cm radio emission from 1I/2017 U1 with the Green Bank telescope
Creators: name: Park, Ryan S.
name: Pisano, D. J.
name: Lazio, T. Joseph W.
name: Chodas, Paul W.
name: Naidu, Shantanu P.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: This paper reports the first OH 18-cm line observation of the first detected interstellar object 1I/2017 U1 (`Oumuamua) using the Green Bank Telescope. We have observed the OH lines at 1665.402 MHz, 1667.359, and 1720.53 MHz frequencies with a spectral resolution of 357 Hz (approximately 0.06 km-s^{-1}). At the time of the observation, `Oumuamua was at topocentric distance and velocity of 1.07 au and 63.4 km-s^{-1}, respectively, or at heliocentric distance and velocity of 1.8 au and 39 km-s^{-1}, respectively. Based on a detailed data reduction and an analogy-based inversion, our final results confirm the asteroidal origin of `Oumuamua (as discussed in Meech et al., 2017) with an upper bound of OH production of Q[OH] < 0.17 x 10^{28} s^{-1}.
description: accepted for publication in Astronomical Journal, 7 pages, 1 figure, 1 table
Additional file 1: of Quality indicators of clinical cancer care for prostate cancer: a population-based study in southern Switzerland
Creators: name: Ortelli, Laura
name: Spitale, Alessandra
name: Mazzucchelli, Luca
name: Bordoni, Andrea
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: List of QI assessed and selected for prostate cancer, according to the clinical domain. This file describes the full list of selected QI for prostate cancer. (PDF 142 kb)
title: Die Abbildung von Bewegungsbahnen in Deformationszonen der Erde mit elektrischen Methoden
Creators: name: Ritter, Oliver
Publisher: name: Deutsches GeoForschungsZentrum GFZ
Year: 2005

description: Mit der vorliegenden Arbeit werden voneinander unabhängige Experimente zur Untersuchung der elektrischen Leitfähigkeit im Untergrund miteinander verknüpft, mit dem Ziel, das Potenzial der Methode Magnetotellurik für das Abbilden aktiver und fossiler tektonischer Systeme aufzuzeigen. Die Magnetotellurik hat sich in den letzten zehn bis fünfzehn Jahren zunehmend zu einem zuverlässigen und aussagekräftigen Tiefensondierungsverfahren entwickelt. Dieser positive Entwicklungsprozess wird auch durch meine Forschungsergebnisse dokumentiert, die in verschiedenen Projekten während meiner Zeit am GeoForschungsZentrum entstanden sind. Eine Übersicht über die verwendeten Arbeiten befindet sich in Tabelle 1.1. Große geophysikalische Feldexperimente, wie die hier beschriebenen Magnetotellurikprojekte, lassen sich nur im Team durchführen. Im akademischen Bereich bedeutet dies die Integration von Studenten und Doktoranden bei den Feldmessungen und der anschließenden Bearbeitung der Daten. Entsprechend gehen einige der in Tabelle 1.1 aufgeführten Arbeiten auf Diplomarbeiten oder Promotionsschriften zurück, die von mir mitbetreut wurden. Bei anschließender Veröffentlichung der Arbeiten habe ich als Co-Autor mitgewirkt. Die beiliegenden Veröffentlichungen enthalten eine Einführung in die Methode der Magnetotellurik und gegebenenfalls die Beschreibung neu entwickelter Methoden. Eine allgemeine Darstellung der theoretischen Grundlagen der Magnetotellurik findet man z.B. in (Kaufman & Keller, 1981; Nabighian, 1987; Weaver, 1994). Am Ende der Arbeit befindet sich ein Glossar, in dem einige Begriffe und Abkürzungen erklärt werden.
description: Scientific Technical Report STR ; 05/10
MAC level Throughput comparison: 802.11ax vs. 802.11ac
Creators: name: Sharon, Oran
name: Alpert, Yaron
Publisher: name: arXiv
Year: 2018
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: In this paper we compare between the maximum Throughputs received in IEEE 802.11ax and IEEE 802.11ac in a scenario where a single user continuously transmits to another one. The comparison is done as a function of the Modulation/Coding scheme in use. In IEEE 802.11ax we consider two modes of operation where in one Acknowledgment frame up to 64 or 256 frames are acknowledged respectively. IEEE 802.11ax outperforms IEEE 802.11ac by at most 48% and 29% in unreliable and reliable channels respectively.
description: 12 pages, 6 figures. arXiv admin note: text overlap with arXiv:1709.04818
The Definition of Entropy for Quantum Unstable Systems: A View-Point Based on the Properties of Gamow States
Creators: name: Civitarese, Osvaldo
name: Gadella, Manuel
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In this paper, we review the concept of entropy in connection with the description of quantum unstable systems. We revise the conventional definition of entropy due to Boltzmann and extend it so as to include the presence of complex-energy states. After introducing a generalized basis of states which includes resonances, and working with amplitudes instead of probabilities, we~found an expression for the entropy which exhibits real and imaginary components. We discuss the meaning of the imaginary part of the entropy on the basis of the similarities existing between thermal and time evolutions.
description: 12 pages
Evaluating the potential for immune escape: how likely is an antibody to protect against a specific SARS-CoV-2 variant?
Creators: name: Sterling, Allyson
name: Lannan, Erica
name: Porter, Sandra
Publisher: name: QUBES Educational Resources
Year: 2024

description: Commercial antibodies to the SARS-CoV-2 spike protein have been successfully used to treat people with COVID-19. Unfortunately, as the SARS-CoV-2 virus evolves, new variants have appeared that can escape some of these antibodies. In fact, many commercial antibodies that received Emergency Use Authorization from the FDA had their status rescinded because they fail to work against newer variants. This project gives students the opportunity to investigate how well different commercial antibodies might work against SARS-CoV-2 variants. In the main research component, students use NextStrain.org to locate emerging variants of SARS-CoV-2 and find the sequences of their spike proteins in GenBank. They use iCn3D and BLAST to align the sequence of the variant spike protein to a sequence of a spike protein that is bound to a commercial antibody. They annotate and identify mutations in the antibody binding site of the variant spike protein. Last, they compare the chemical bonds that would be formed between the original amino acid and the antibody with the predicted bonds that could be formed by the variant amino acid and predict whether their antibody will be effective against their variant.
Can perturbative QCD predict a substantial part of diffractive LHC/SSC physics?
Creators: name: Cudell, J. R.
name: Margolis, B.
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We examine a model of hadronic diffractive scattering which interpolates between perturbative QCD and non-perturbative fits. We restrict the perturbative QCD resummation to the large transverse momentum region, and use a simple Regge-pole parametrization in the infrared region. This picture allows us to account for existing data, and to estimate the size of the perturbative contribution to future diffractive measurements. At LHC and SSC energies, we find that a cut-off BFKL equation can lead to a measurable perturbative component in traditionally soft processes. In particular, we show that the total pp cross section could become as large as 228 mb (160 mb) and the rho parameter as large as 0.23 (0.24) at the SSC (LHC).
description: 9 pages, McGill/92-37
Quasi-binary amorphous phase in a 3D system of particles with repulsive-shoulder interactions
Creators: name: Fomin, Yu. D.
name: Frenkel, Daan
name: Gribova, N. V.
name: Ryzhov, V. N.
name: Stishov, S. M.
Publisher: name: arXiv
Year: 2007
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We report a computer-simulation study of the equilibrium phase diagram of a three-dimensional system of particles with a repulsive step potential. Using free-energy calculations, we have determined the equilibrium phase diagram of this system. At low temperatures, we observe a number of distinct crystal phases. However, under certain conditions the system undergoes a glass transition in a regime where the liquid appears thermodynamically stable. We argue that the appearance of this amorphous low-temperature phase can be understood by viewing this one-component system as a pseudo-binary mixture.
description: 4 pages, 4 figures
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VIII, Cart. 192 (11 H 77), 295 folios, f. 0198v
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VIII, Archives départementales de la Côte-d'Or, Cart. 192 (11 H 77), 295 folios, f. 0198v, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VIII, Archives départementales de la Côte-d'Or, Cart. 192 (11 H 77), 295 folios, f. 0198v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
What we talk about when we talk about monads
Creators: name: Petricek, Tomas
Publisher: name: arXiv
Year: 2018
Subjects: subject: Programming Languages (cs.PL)
subject: FOS: Computer and information sciences

description: Computer science provides an in-depth understanding of technical aspects of programming concepts, but if we want to understand how programming concepts evolve, how programmers think and talk about them and how they are used in practice, we need to consider a broader perspective that includes historical, philosophical and cognitive aspects. In this paper, we develop such broader understanding of monads, a programming concept that has an infamous formal definition, syntactic support in several programming languages and a reputation for being elegant and powerful, but also intimidating and difficult to grasp. This paper is not a monad tutorial. It will not tell you what a monad is. Instead, it helps you understand how computer scientists and programmers talk about monads and why they do so. To answer these questions, we review the history of monads in the context of programming and study the development through the perspectives of philosophy of science, philosophy of mathematics and cognitive sciences. More generally, we present a framework for understanding programming concepts that considers them at three levels: formal, metaphorical and implementation. We base such observations on established results about the scientific method and mathematical entities -- cognitive sciences suggest that the metaphors used when thinking about monads are more important than widely accepted, while philosophy of science explains how the research paradigm from which monads originate influences and restricts their use. Finally, we provide evidence for why a broader philosophical, sociological look at programming concepts should be of interest for programmers. It lets us understand programming concepts better and, fundamentally, choose more appropriate abstractions as illustrated in number of case studies that conclude the paper.
Non-Gaussian statistics of pencil beam surveys
Creators: name: Amendola, Luca
Publisher: name: arXiv
Year: 1994
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We study the effect of the non-Gaussian clustering of galaxies on the statistics of pencil beam surveys. We find that the higher order moments of the galaxy distribution play an important role in the probability distribution for the power spectrum peaks. Taking into account the observed values for the kurtosis of galaxy distribution we derive the general probability distribution for the power spectrum modes in non-Gaussian models and show that the probability to obtain the 128$\hm$ periodicity found in pencil beam surveys is raised by roughly one order of magnitude. The non-Gaussianity of the galaxy distribution is however still insufficient to explain the reported peak-to-noise ratio of the periodicity, so that extra power on large scales seems required.
description: 9 pages,2 figs available on request,Latex, revised version with significant changes, preprint Fermilab-Pub-94-043-A
Structural Disorder and Elementary Magnetic Properties of Triangular Lattice ErMgGaO4 Single Crystals
Creators: name: Cevallos, F. Alex
name: Stolze, Karoline
name: Cava, Robert J.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The single crystal growth, structure, and basic magnetic properties of ErMgGaO4 are reported. The structure consists of triangular layers of magnetic ErO6 octahedra separated by a double layer of randomly occupied non-magnetic (Ga,Mg)O5 bipyramids. The Er atoms are positionally disordered. Magnetic measurements parallel and perpendicular to the c axis of a single crystal reveal dominantly antiferromagnetic interactions, with a small degree of magnetic anisotropy. A weighted average of the directional data suggests an antiferromagnetic Curie Weiss temperature of approximately -30 K. Below 10 K the temperature dependences of the inverse susceptibilities in the in-plane and perpendicular-to plane directions are parallel, indicative of an isotropic magnetic moment at low temperatures. No sign of magnetic ordering is observed above 1.8 K, suggesting that ErMgGaO4 is a geometrically frustrated magnet.
description: 10 pages, 3 figures, 2 tables, supplementary info
Properties of 3-manifolds for relativists
Creators: name: Giulini, Domenico
Publisher: name: arXiv
Year: 1993
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In canonical quantum gravity certain topological properties of 3-manifolds are of interest. This article gives an account of those properties which have so far received sufficient attention, especially those concerning the diffeomorphism groups of 3-manifolds. We give a summary of these properties and list some old and new results concerning them. The appendix contains a discussion of the group of large diffeomorphisms of the $l$-handle 3-manifold.
description: 20 pages. Plain-TeX, no figures, 1 Table (A4 format)
Ground state of dipolar hard spheres confined in channels
Creators: name: Deißenbeck, Florian
name: Löwen, Hartmut
name: Oğuz, Erdal C.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We investigate the ground state of a classical two-dimensional system of hard-sphere dipoles confined between two hard walls. Using lattice sum minimization techniques we reveal that at fixed wall separations, a first-order transition from a vacuum to a straight one-dimensional chain of dipoles occurs upon increasing the density. Further increase in the density yields the stability of an undulated chain as well as nontrivial buckling structures. We explore the close-packed configurations of dipoles in detail, and we find that, in general, the densest packings of dipoles possess complex magnetizations along the principal axis of the slit. Our predictions serve as a guideline for experiments with granular dipolar and magnetic colloidal suspensions confined in slit-like channel geometry.
description: 6 pages, 3 figures
Additional file 14: of Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control
Creators: name: MartĂ­Nez-Lumbreras, Santiago
name: Krysztofinska, Ewelina
name: Thapaliya, Arjun
name: Spilotros, Alessandro
name: Matak-Vinkovic, Dijana
name: Salvadori, Enrico
name: Roboti, Peristera
name: Nyathi, Yvonne
name: Muench, Janina
name: Roessler, Maxie
name: Svergun, Dmitri
name: High, Stephen
name: Isaacson, Rivka
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Inorganic Chemistry
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Figure S13. CW-EPR spectra of the FL and C-terminal deleted (NT-TPR) SGTA proteins. Room Temperature CW-EPR spectra for SGTA FL mutants (blue lines) and corresponding NT-TPR constructs (red lines). CW-EPR spectra mainly provide information about the mobility of the spin labels and thus about the local environment of the labeled residues. Spectra of the FL protein are slightly broader than those corresponding to the C-terminal deletion (NT-TPR), as highlighted by arrows in the figure, suggesting that the absence C-terminal domain increase the overall mobility of the TPR domain. (PDF 559 kb)
Rare Kaon Decays in the $1/N_c$-Expansion
Creators: name: Bruno, C.
name: Prades, J.
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the unknown coupling constants that appear at order $p^4$ in the Chiral Perturbation Theory analysis of $K \to πγ^* \to πl^+ l^-$, $K^{+-} \to π^{+-} γγ$ and $K \to ππγ$ decays. To that end, we compute the chiral realization of the $ΔS \, = \, 1$ Hamiltonian in the framework of the $1/N_c$-expansion of the low-energy action. The phenomenological implications are also discussed.
description: 18 pages, LaTeX, CPT-92/P.2795
The effect of the X-linked Inhibitor-of-Apoptosis Protein on the release of Smac from the mitochondria during Apoptosis
Creators: name: Flanagan, Lorna
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: XIAP is a potent inhibitor of caspases-3, -7, and -9, and mitochondrial Smac release during apoptosis inhibits the activity of XIAP. The work in this thesis demonstrates that cytosolic XIAP also feeds back to mitochondria to impair Smac release. We constructed a fluorescent XIAP-fusion protein by labelling NH2- and COOH-termini with cerulean fluorescent protein (C-XIAP-C). Immunoprecipitation confirmed that C-XIAP-C retained the ability to interact with Smac and impaired extrinsically and intrinsically activated apoptosis in response to TRAILICHX and staurosporine. In C-XIAP-C expressing cells,cytochrome-c release from mitochondria proceeded normally whereas Smac release was significantly prolonged and incomplete. Also physiological expression of native XIAP prolonged or limited Smac release in HCT-116 colon cancer cells and primary mouse cortical neurons. The Smac-binding capacity of XIAP, but not caspase inhibition was central for mitochondria1 Smac retention, as evidenced in experiments employing XIAP mutants that cannot bind to Smac or effector caspases. Likewise, the release of a Smac mutant that cannot bind to XIAP was not impaired by C-XIAP-C expression. Full Smac release could however be provoked by rapid cytosolic C-XIAP-C depletion upon digitonin-induced plasma membrane permeabilisation. These findings suggest that even though mitochondria may already contain pores sufficient for cytochrome-c release, elevated amounts of XIAP can selectively impair and limit the release of Smac. Furthermore native Smac dimerises to form a highly stable and inflexible elongated arch, however, a functional role for this outstretched structure so far remained unknown. Using time-lapse single-cell imaging of DLD-1 and HCT-116 colon cancer cells, we demonstrate that upon mitochondria1 outer membrane permeabilisation physiological expression levels of XIAP are sufficient to selectively prolong the release of dimeric but not monomeric Smac. Elevating the expression of XIAP further extended to release duration of dimeric Smac and resulted in the mitrochondrial retention of a significant proportion of the Smac pool. In contrast, monomeric Smac was always fully released and the release kinetics were not affected by altered XIAP expression. The findings presented therefore indicate that the dimerisation of Smac is critical for the XIAP-mediated retention of Smac at or inside the mitochondria.
Lower limits for distributions of randomly stopped sums
Creators: name: Denisov, Denis
name: Foss, Sergey
name: Korshunov, Dmitry
Publisher: name: arXiv
Year: 2007
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: Primary 60E05, secondary 60F10

description: We study lower limits for the ratio $\frac{\bar{F^{*τ}}(x)}{\bar F(x)}$ of tail distributions where $ F^{*τ}$ is a distribution of a sum of a random size $τ$ of i.i.d. random variables having a common distribution $F$, and a random variable $τ$ does not depend on summands.
description: This research is a continuation of arXiv:math/0510273 and arXiv:math/0701920. 11 pages
Additional file 1: of Molecular characterization of Cryptosporidium spp. and Giardia duodenalis in children in Egypt
Creators: name: Doaa Naguib
name: El-Gohary, Adel
name: Roellig, Dawn
name: Mohamed, Amro
name: Nagah Arafat
name: Yuanfei Wang
name: Yaoyu Feng
name: Lihua Xiao
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Computational Biology

description: Table S1. Specimens from kindergarten-age children in Egypt that were positive for Giardia duodenalis assemblage B at the tpi, gdh and bg loci. (DOCX 16 kb)
Short time scale monitoring of SiO sources
Creators: name: Pijpers, F. P.
name: Pardo, J. R.
name: Bujarrabal, V.
Publisher: name: arXiv
Year: 1994
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present the results of a short time scale monitoring of SiO maser emission (v=1 J=1-0 transition) in four known strong sources. These sources were monitored nightly for a period of about a month. The aim of these observations is to investigate the possible presence of variations in the maser lines on time scales of a few days to weeks, due to sound waves propagating out from the central star. If sound waves are responsible for the mass loss of certain cool giants, as suggested by Pijpers and Hearn (1989) and Pijpers and Habing (1989), local variations in density and relative velocity are expected just above the stellar photosphere. These could give rise to variations in any narrow spectral line formed in this region, and therefore in particular in the SiO maser lines. Our observations indicate that variations in the line shape (leading to relative changes in the intensity of about 20\%) occur in the SiO emission of Mira type stars, within short time scales of 10-20 days. The main component of the profile variability is consistent with a displacement of the velocity centroid of the dominant maser peaks, by about 1 km s$^{-1}$ in the average. Apparent variations in the total line flux were also found, but could be partially due to calibration uncertainties.
description: 7 pages, plain TeX + A&A macros
Proactive Empirical Assessment of New Language Feature Adoption via Automated Refactoring: The Case of Java 8 Default Methods
Creators: name: Khatchadourian, Raffi
name: Masuhara, Hidehiko
Publisher: name: arXiv
Year: 2018
Subjects: subject: Programming Languages (cs.PL)
subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: Programming languages and platforms improve over time, sometimes resulting in new language features that offer many benefits. However, despite these benefits, developers may not always be willing to adopt them in their projects for various reasons. In this paper, we describe an empirical study where we assess the adoption of a particular new language feature. Studying how developers use (or do not use) new language features is important in programming language research and engineering because it gives designers insight into the usability of the language to create meaning programs in that language. This knowledge, in turn, can drive future innovations in the area. Here, we explore Java 8 default methods, which allow interfaces to contain (instance) method implementations. Default methods can ease interface evolution, make certain ubiquitous design patterns redundant, and improve both modularity and maintainability. A focus of this work is to discover, through a scientific approach and a novel technique, situations where developers found these constructs useful and where they did not, and the reasons for each. Although several studies center around assessing new language features, to the best of our knowledge, this kind of construct has not been previously considered. Despite their benefits, we found that developers did not adopt default methods in all situations. Our study consisted of submitting pull requests introducing the language feature to 19 real-world, open source Java projects without altering original program semantics. This novel assessment technique is proactive in that the adoption was driven by an automatic refactoring approach rather than waiting for developers to discover and integrate the feature themselves. In this way, we set forth best practices and patterns of using the language feature effectively earlier rather than later and are able to possibly guide (near) future language evolution. We foresee this technique to be useful in assessing other new language features, design patterns, and other programming idioms.
The Quantum Propagator for a Nonrelativistic Particle in the Vicinity of a Time Machine
Creators: name: Goldwirth, Dalia S.
name: Perry, Malcolm J.
name: Piran, Tsvi
name: Thorne, Kip S.
Publisher: name: arXiv
Year: 1993
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Astrophysics (astro-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the propagator of a non-relativistic, non-interacting particle in any non-relativistic ``time-machine'' spacetime of the type shown in Fig.~1: an external, flat spacetime in which two spatial regions, $V_-$ at time $t_-$ and $V_+$ at time $t_+$, are connected by two temporal wormholes, one leading from the past side of $V_-$ to t the future side of $V_+$ and the other from the past side of $V_+$ to the future side of $V_-$. We express the propagator explicitly in terms of those for ordinary, flat spacetime and for the two wormholes; and from that expression we show that the propagator satisfies completeness and unitarity in the initial and final ``chronal regions'' (regions without closed timelike curves) and its propagation from the initial region to the final region is unitary. However, within the time machine it satisfies neither completeness nor unitarity. We also give an alternative proof of initial-region-to-final-region unitarity based on a conserved current and Gauss's theorem. This proof can be carried over without change to most any non-relativistic time-machine spacetime; it is the non-relativistic version of a theorem by Friedman, Papastamatiou and Simon, which says that for a free scalar field, quantum mechanical unitarity follows from the fact that the classical evolution preserves the Klein-Gordon inner product.
Supersymmetric Grand Unified Theories: Two Loop Evolution of Gauge and Yukawa Couplings
Creators: name: Barger, V.
name: Berger, M. S.
name: Ohmann, P.
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We make a numerical study of gauge and Yukawa unification in supersymmetric grand unified models and examine the quantitative implications of fermion mass ansätze at the grand unified scale. Integrating the renormalization group equations with $α_1(M_Z)$ and $α_2(M_Z)$ as inputs, we find $α_3(M_Z)\simeq 0.111 (0.122)$ for $M_{SUSY}^{}=m_t$ and $α_3(M_Z)\simeq 0.106 (0.116)$ for $M_{SUSY}^{}=1$ TeV at one-loop (two-loop) order. Including $b$ and $τ$ Yukawa couplings in the evolution, we find an upper limit $m_t\ltap 200$ GeV from Yukawa unification. For given $m_t\ltap 175$ GeV, there are two solutions for $β$, one with $\tan β> m_t/m_b$, and one with $\sin β\simeq 0.78(m_t/150\;{\rm GeV})$. Taking a popular ansatz for the mass matrices at the unified scale, we obtain a lower limit on the top quark mass of $m_t\gtap 150 (115)$ GeV for $α_3(M_Z)=0.11 (0.12)$ and an upper limit on the supersymmetry parameter $\tan β\ltap 50$ if $α_3(M_Z)=0.11$. The evolution of the quark mixing matrix elements is also evaluated.
description: 46 pages + 11 figures not included (available on request), MAD/PH/711
Additional file 9: of Hepatitis B virus infection among pregnant women in Ethiopia: a systematic review and Meta-analysis of prevalence studies
Creators: name: Kindie Kebede
name: Dejene Abateneh
name: Alemayehu Belay
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Sub-group meta-analysis by JBI methodological quality among pregnant women in Ethiopia. (DOCX 1467 kb)
Engineering the spin–orbit interaction in surface conducting diamond with a solid-state gate dielectric
Creators: name: Xing, Kaijian
name: Tsai, Alexander
name: Creedon, Daniel L
name: Yianni, Steve
name: McCallum, Jeffrey C
name: Ley, Lothar
name: Qi, Dongchen
name: Pakes, Christopher
Publisher: name: La Trobe
Year: 2025
Subjects: classificationCode: 51
subject: Physical sciences
subject: FOS: Physical sciences
classificationCode: 40
subject: Engineering
classificationCode: 5104
subject: Condensed matter physics
classificationCode: 4018
subject: Nanotechnology
subject: FOS: Nanotechnology

description: Abstract: Hydrogen-terminated (H-terminated) diamond, when surface transfer doped, can support a sub-surface two-dimensional (2D) hole band that possesses a strong Rashba-type spin-orbit interaction. By incorporating a V2O5/Al2O3 bilayer gate dielectric in a diamond-based metal-oxide-semiconductor architecture, metallic surface conductivity can be maintained at low temperature, avoiding the carrier freeze out exhibited by devices with an Al2O3 gate dielectric alone. Hole densities of up to 2.5 × 1013 cm-2 are achieved by the electrostatic gating of the device, and the spin-orbit interaction strength can be tuned from 3.5 ± 0.5 meV to 8.4 ± 0.5 meV, with a concurrent reduction in the spin coherence length from 40 ± 1 nm to 27 ± 1 nm. The demonstration of a gated device architecture on the H-terminated that avoids the need to cycle the temperature, as is required for ionic liquid gating protocols, opens a pathway to engineering practical devices for the study and application of spin transport in diamond.
Harmonizing Signals and Events with a Lightweight Extension to Java
Creators: name: Kamina, Tetsuo
name: Aotani, Tomoyuki
Publisher: name: arXiv
Year: 2018
Subjects: subject: Programming Languages (cs.PL)
subject: FOS: Computer and information sciences

description: The current demands for seamless connections with the surrounding environment make software more reactive. For example, such demands are evident in systems consisting of the Internet of Things. Such systems include a set of reactive values that are periodically updated in response to external or internal events to form a dataflow in the sense that such updates are propagated to other reactive values. Two effective approaches for realizing such reactive values have been proposed: the event mechanisms in event-based programming and the signals in functional-reactive programming. These two approaches are now becoming mixed in several languages such as Flapjax and REScala, which makes these languages notably expressive for modularizing the implementation of reactive software. For example, REScala provides a rich API that consists of functions converting events to signals and vice versa. In this paper, we explore another, simpler approach in the design space of reactive programming languages: the event mechanism is harmonized with signals, resulting in a simplified programming interface that is mostly based on signals. Based on this approach, we realize SignalJ, a simple extension of Java with events and signals. Our notable findings are (1) an event can be represented as an update of a signal and (2) such an effectful signal can be represented using annotations instead of introducing types and constructors for signals to further simplify the language. Another contribution of this paper is the formal model of SignalJ. As both mechanisms of events and signals may interfere with each other, this mixing sometimes results in surprising behavior. For example, the functional behavior of signals is affected by the imperative features of events. Thus, understanding the formal model of this mixing is actually important. The core calculus, Featherweight SignalJ (FSJ), was developed as an extension of Featherweight Java, and proofs are provided to ensure the soundness of FSJ.
Astronomical constraints on some long-range models of modified gravity
Creators: name: Iorio, Lorenzo
Publisher: name: arXiv
Year: 2007
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Astrophysics (astro-ph)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: In this paper we use the corrections to the usual Newton-Einstein secular precessions of the perihelia of the inner planets of the Solar System, phenomenologically estimated as solve-for parameters by the Russian astronomer E.V. Pitjeva by fitting almost one century of data with the EPM2004 ephemerides, in order to constrain some long-range models of modified gravity recently put forth to address the dark energy and dark matter problems. The models examined here are the four-dimensional ones obtained with the addition of inverse powers and logarithm of some curvature invariants, and the multidimensional braneworld model by Dvali, Gabadadze and Porrati (DGP). After working out the analytical expressions of the secular perihelion precessions induced by the corrections to the Newtonian potential of such models, we compare them to the estimated corrections to the rates of perihelia by taking their ratio for different pairs of planets instead of using one perihelion at a time for each planet separately, as done so far in literature. As a result, the curvature invariants-based models are ruled out, even by re-scaling by a factor 10 the errors in the planetary orbital parameters estimated by Pitjeva. Less neat is the situation for the DGP model. Only the general relativistic Lense-Thirring effect, not included, as the other exotic models considered here, by Pitjeva in the dynamical force models used in the estimation process, passes such a test. It would be important to repeat the present analysis by using corrections to the precessions of perihelia independently estimated by other teams of astronomers as well, but, at present, such rates are not yet available.
description: Latex, 13 pages, no figures, 1 table. Other references added. Minor stylistic changes. To appear in AHEP (Advances in High Energy Physics). Typo corrected in eq. 6: thanks to G.E. Melki