cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Masculinity in the Later Novels of Thomas Hardy
Creators: name: Kamezawa, Miyuki
Publisher: name: University of Leicester
Year: 2023
Subjects: Uncategorized

description: This thesis explores the representation of masculinity in Thomas Hardy’s works, in an attempt to understand his reactions to the socio-economic changes and materialism of the late nineteenth century. With the spread of a credit finance economy, Hardy saw investment culture generating economic, social and psychological turmoil. His particular concern was with the disappearance of absolute value (of gold), which was replaced by the relativism of fictional paper money, such as shares, bonds, and cheques. The objective of the thesis is to examine Hardy’s male characters in connection with the exchange systems of money, women and words, which I call, as one integrated system, the symbolic economy. To do this, the thesis adopts two perspectives. The first is the analysis of male characters according to the constructionist gender theories initiated by Eve Kosofsky Sedgwick. What becomes clear is that male homosocial desire is interlaced with non-gender issues, such as national identity, and the rise of writing culture replacing orality. Through these interactions, the analysis will consider the formation of distinctive styles of masculinity. However, a pattern emerges that is incongruous with gender studies. Compromised masculinity is accompanied by a ghostly image of the world. In this, the issue of gender relationships recedes into the background, and the world of objects comes forward as a threat to men. At this point, my argument shifts to focus on the connection between men in relation to the world of objects. To augment the argument for this second perspective, I adopt Bill Brown’s Thing Theory. By exploiting his concept of ‘thingness’, in conjunction with a consideration of allegory and metonymy, the thesis exposes materialism in the act of abstracting human subjectivity. In Hardy’s novels, male subjects are threatened by objectification into simulacra by the world of objects. By employing these two perspectives, the thesis reveals Hardy’s philosophy about the integrated network of the symbolic economy, in which gender is only a part, albeit an important one. The novels examined in the thesis are: The Trumpet-Major, The Mayor of Casterbridge, The Woodlanders, Tess of the D’Urbervilles, and Jude the Obscure.
Identification of a Robust Methylation Classifier for Cutaneous Melanoma Diagnosis
Creators: name: Kuan, P.F.
name: Edmiston, S.N.
name: Slater, N.A.
name: Wilkerson, M.D.
name: Conway, K.
name: Carson, C.C.
name: Pearlstein, M.V.
name: Frank, J.S.
name: Groben, P.A.
name: Moschos, S.J.
name: Scott, G.A.
name: Parrish, E.A.
name: Tsai, Y.-H.
name: Zhao, X.
name: Hao, H.
name: Thomas, N.E.
name: Parker, J.S.
name: Zedek, D.C.
name: Ollila, D.W.
Publisher: name: Elsevier B.V.
Year: 2019

description: Early diagnosis improves melanoma survival, yet the histopathological diagnosis of cutaneous primary melanoma can be challenging, even for expert dermatopathologists. Analysis of epigenetic alterations, such as DNA methylation, that occur in melanoma can aid in its early diagnosis. Using a genome-wide methylation screening, we assessed CpG methylation in a diverse set of 89 primary invasive melanomas, 73 nevi, and 41 melanocytic proliferations of uncertain malignant potential, classified based on interobserver review by dermatopathologists. Melanomas and nevi were split into training and validation sets. Predictive modeling in the training set using ElasticNet identified a 40-CpG classifier distinguishing 60 melanomas from 48 nevi. High diagnostic accuracy (area under the receiver operator characteristic curve = 0.996, sensitivity = 96.6%, and specificity = 100.0%)was independently confirmed in the validation set (29 melanomas, 25 nevi)and other published sample sets. The 40-CpG melanoma classifier included homeobox transcription factors and genes with roles in stem cell pluripotency or the nervous system. Application of the 40-CpG melanoma classifier to the diagnostically uncertain samples assigned melanoma or nevus status, potentially offering a diagnostic tool to assist dermatopathologists. In summary, the robust, accurate 40-CpG melanoma classifier offers a promising assay for improving primary melanoma diagnosis.
Histone deacetylase 11 inhibition promotes breast cancer metastasis from lymph nodes
Creators: name: Leslie, P.L.
name: Chao, Y.L.
name: Harrison, E.B.
name: Cooley, B.C.
name: Ghosh, S.K.
name: Pecot, C.V.
name: Parker, J.S.
name: Porrello, A.
name: Carey, L.A.
name: Van Swearingen, A.E.D.
name: Tsai, Y.-H.
Publisher: name: Nature Publishing Group
Year: 2019

description: Lymph node (LN) metastases correspond with a worse prognosis in nearly all cancers, yet the occurrence of cancer spreading from LNs remains controversial. Additionally, the mechanisms explaining how cancers survive and exit LNs are largely unknown. Here, we show that breast cancer patients frequently have LN metastases that closely resemble distant metastases. In addition, using a microsurgical model, we show how LN metastasis development and dissemination is regulated by the expression of a chromatin modifier, histone deacetylase 11 (HDAC11). Genetic and pharmacologic blockade of HDAC11 decreases LN tumor growth, yet substantially increases migration and distant metastasis formation. Collectively, we reveal a mechanism explaining how HDAC11 plasticity promotes breast cancer growth as well as dissemination from LNs and suggest caution with the use of HDAC inhibitors.
A Thesis Submitted to the Department of Management in Partial Fulfillment of the Requirements for Master of Business Administration
Creators: name: Endalew Assefa
Publisher: name: Zenodo
Year: 2019

description: The purpose of this study was to explore the level of academic staff job satisfaction and its possible predictors

at Addis Ababa University. For accomplishing this purpose, primary data were collected from the target

population by applying stratified proportionate sampling within which random and availability sampling were

involved. The data collection tools were survey questionnaire and key informant interview. Then, data were

analyzed descriptively in order to catch the trends in light of the stated issue. Once descriptions were made,

ANOVA and T-test were conducted to compare the variation in the average satisfaction values of respondents

belonging to different demographic sub-categories. Correlation analysis was also undertaken so as to show the

association between predictor variables and the dependent variable. Finally linear multiple regression analysis

was run to examine the effect of predictor variables on the dependent variable. The research revealed that, on

average, the academic staffs were dissatisfied. Some group of staffs relating to highest extremes of academic

rank and age as well as service year were, however, somehow closer to neutral being neither dissatisfied nor

satisfied.
MPEC 2024-R222 : DAILY ORBIT UPDATE (2024 September 9)
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Genetic determinants of cellular addiction to DNA polymerase theta
Creators: name: Simpson, D.A.
name: Mose, L.E.
name: Wood, R.D.
name: Carvajal-Garcia, J.
name: Gupta, G.P.
name: Purvis, J.E.
name: Rashid, N.
name: Price, B.A.
name: Feng, W.
name: Parker, J.S.
name: Kumar, R.J.
name: Ramsden, D.A.
Publisher: name: Nature Publishing Group
Year: 2019

description: Polymerase theta (Pol θ, gene name Polq) is a widely conserved DNA polymerase that mediates a microhomology-mediated, error-prone, double strand break (DSB) repair pathway, referred to as Theta Mediated End Joining (TMEJ). Cells with homologous recombination deficiency are reliant on TMEJ for DSB repair. It is unknown whether deficiencies in other components of the DNA damage response (DDR) also result in Pol θ addiction. Here we use a CRISPR genetic screen to uncover 140 Polq synthetic lethal (PolqSL) genes, the majority of which were previously unknown. Functional analyses indicate that Pol θ/TMEJ addiction is associated with increased levels of replication-associated DSBs, regardless of the initial source of damage. We further demonstrate that approximately 30% of TCGA breast cancers have genetic alterations in PolqSL genes and exhibit genomic scars of Pol θ/TMEJ hyperactivity, thereby substantially expanding the subset of human cancers for which Pol θ inhibition represents a promising therapeutic strategy.
Genetic determinants of the molecular portraits of epithelial cancers
Creators: name: Parker, J.S.
name: Hoadley, K.A.
name: Fan, C.
name: Xia, Y.
name: Perou, C.M.
Publisher: name: Nature Research
Year: 2019

description: The ability to characterize and predict tumor phenotypes is crucial to precision medicine. In this study, we present an integrative computational approach using a genome-wide association analysis and an Elastic Net prediction method to analyze the relationship between DNA copy number alterations and an archive of gene expression signatures. Across breast cancers, we are able to quantitatively predict many gene signatures levels within individual tumors with high accuracy based upon DNA copy number features alone, including proliferation status and Estrogen-signaling pathway activity. We can also predict many other key phenotypes, including intrinsic molecular subtypes, estrogen receptor status, and TP53 mutation. This approach is also applied to TCGA Pan-Cancer, which identify repeatedly predictable signatures across tumor types including immune features in lung squamous and basal-like breast cancers. These Elastic Net DNA predictors could also be called from DNA-based gene panels, thus facilitating their use as biomarkers to guide therapeutic decision making.
Effects of sodium silicate as liquid phase sintering additives on properties of alumina ceramics
Creators: name: Kanyapak SIRIPHAISARNTAVEE
Publisher: name: Metallurgy and Materials Science Research Institute Chulalongkorn University
Year: 2020
Subjects: Liquid phase sintering
Sodium silicate
Alumina ceramics
Extrusion

description: Journal of Metals Materials and Minerals, 30, 2, 105-109
Systematic Coarse-Graining in Nucleation Theory
Creators: name: Schweizer, Marco
name: Sagis, Leonard
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: In this work we show that the standard method to obtain nucleation rate-predictions with the aid of atomistic Monte-Carlo simulations leads to nucleation rate predictions that deviate $3-5$ orders of magnitude from the recent brute-force molecular dynamics simulations [J. Diemand, R. Angélil, K. K. Tanaka, and H. Tanaka, J. Chem. Phys. \textbf{139}, 074309 (2013)] conducted in the experimental accessible supersaturation regime for Lennard-Jones argon. We argue that this is due to the truncated state space literature mostly relies on, where the number of atoms in a nucleus is considered the only relevant order parameter. We here formulate the nonequilibrium statistical mechanics of nucleation in an extended state space, where the internal energy and momentum of the nuclei is additionally incorporated. We show that the extended model explains the lack in agreement between the molecular dynamics simulations by Diemand et al.\ and the truncated state space. We demonstrate additional benefits of using the extended state space; in particular, the definition of a nucleus temperature arrises very naturally and can be shown without further approximation to obey the fluctuation law of McGraw and Laviolette. In addition, we illustrate that our theory conveniently allows to extend existing theories to richer sets of order parameters.
Cells exhibiting strong p16 INK4a promoter activation in vivo display features of senescence
Creators: name: Parker, J.S.
name: Diekman, B.O.
name: Sharpless, N.E.
name: Souroullas, G.P.
name: Liu, J.-Y.
name: Krishnamurthy, J.
name: Sessions, G.A.
name: Gudkov, A.V.
name: Sorrentino, J.A.
name: Hall, B.M.
Publisher: name: National Academy of Sciences
Year: 2019

description: The activation of cellular senescence throughout the lifespan promotes tumor suppression, whereas the persistence of senescent cells contributes to aspects of aging. This theory has been limited, however, by an inability to identify and isolate individual senescent cells within an intact organism. Toward that end, we generated a murine reporter strain by “knocking-in” a fluorochrome, tandem-dimer Tomato (tdTom), into exon 1α of the p16 INK4a locus. We used this allele (p16 tdTom ) for the enumeration, isolation, and characterization of individual p16 INK4a -expressing cells (tdTom + ). The half-life of the knocked-in transcript was shorter than that of the endogenous p16 INK4a mRNA, and therefore reporter expression better correlated with p16 INK4a promoter activation than p16 INK4a transcript abundance. The frequency of tdTom + cells increased with serial passage in cultured murine embryo fibroblasts from p16 tdTom/+ mice. In adult mice, tdTom + cells could be readily detected at low frequency in many tissues, and the frequency of these cells increased with aging. Using an in vivo model of peritoneal inflammation, we compared the phenotype of cells with or without activation of p16 INK4a and found that tdTom + macrophages exhibited some features of senescence, including reduced proliferation, senescence-associated β-galactosidase (SA-β-gal) activation, and increased mRNA expression of a subset of transcripts encoding factors involved in SA-secretory phenotype (SASP). These results indicate that cells harboring activation of the p16 INK4a promoter accumulate with aging and inflammation in vivo, and display characteristics of senescence.
Interaction between androgen receptor and coregulator SLIRP is regulated by Ack1 tyrosine kinase and androgen
Creators: name: Xu, C.
name: Wang, G.G.
name: Cai, L.
name: De Silva, D.
name: Zhang, Z.
name: Whang, Y.E.
name: Earp, H.S.
name: Parker, J.S.
name: Liu, Y.
Publisher: name: Nature Research
Year: 2019

description: Aberrant activation of the androgen receptor (AR) may play a critical role in castration resistant prostate cancer. After ligand binding, AR is recruited to the androgen responsive element (ARE) sequences on the DNA where AR interaction with coactivators and corepressors modulates transcription. We demonstrated that phosphorylation of AR at Tyr-267 by Ack1/TNK2 tyrosine kinase results in nuclear translocation, DNA binding, and androgen-dependent gene transcription in a low androgen environment. In order to dissect downstream mechanisms, we searched for proteins whose interaction with AR was regulated by Ack1. SLIRP (SRA stem-loop interacting RNA binding protein) was identified as a candidate protein. Interaction between AR and SLIRP was disrupted by Ack1 kinase activity as well as androgen or heregulin treatment. The noncoding RNA, SRA, was required for AR-SLIRP interaction. SLIRP was bound to ARE’s of AR target genes in the absence of androgen. Treatment with androgen or heregulin led to dissociation of SLIRP from the ARE. Whole transcriptome analysis of SLIRP knockdown in androgen responsive LNCaP cells showed that SLIRP affects a significant subset of androgen-regulated genes. Our data suggest that Ack1 kinase and androgen regulate interaction between AR and SLIRP and that SLIRP functions as a coregulator of AR with properties of a corepressor in a context-dependent manner.
Data Steward's RDM Elements List
Creators: name: Muhammad, Naeem
Publisher: name: Zenodo
Year: 2023
Subjects: RDM, Research Data Management, Data Steward, RDM Support Staff, RDM Elements

description: This document contains a list of Research Data Management (RDM) elements. At the time of interaction with researchers, RDM support staff can use this list to make sure they gather (cover) information about all important aspects of RDM.
Research on Solution Space of Bipartite Graph Vertex-Cover by Maximum Matchings
Creators: name: Wei, Wei
name: Zhang, Yunjia
name: Wang, Ting
name: Li, Baifeng
name: Niu, Baolong
name: Zheng, Zhiming
Publisher: name: arXiv
Year: 2015
Subjects: subject: Data Structures and Algorithms (cs.DS)
subject: FOS: Computer and information sciences

description: Some rigorous results and statistics of the solution space of Vertex-Covers on bipartite graphs are given in this paper. Based on the $K\ddot{o}nig$'s theorem, an exact solution space expression algorithm is proposed and statistical analysis of the nodes' states is provided. The statistical results fit well with the algorithmic results until the emergence of the unfrozen core, which makes the fluctuation of statistical quantities and causes the replica symmetric breaking in the solutions. Besides, the entropy of bipartite Vertex-Cover solutions is calculated with the clustering entropy using a cycle simplification technique for the unfrozen core. Furthermore, as generalization of bipartite graphs, bipartite core graph is proposed, the solution space of which can also be easily determined; and based on these results, how to generate a $K\ddot{o}nig-Egerv\acute{a}ry$ subgraph is studied by a growth process of adding edges. The investigation of solution space of bipartite graph Vertex-Cover provides intensive understanding and some insights on the solution space complexity, and will produce benefit for finding maximal $K\ddot{o}nig-Egerv\acute{a}ry$ subgraphs, solving general graph Vertex-Cover and recognizing the intrinsic hardness of NP-complete problems.
description: 19 pages, 8 figures
Utility of TERT Promoter Mutations for Cutaneous Primary Melanoma Diagnosis
Creators: name: Ollila, D.W.
name: Slater, N.A.
name: Tsai, Y.S.
name: Parrish, E.A.
name: Busam, K.J.
name: Hao, H.
name: Kuan, P.F.
name: Thomas, N.E.
name: Conway, K.
name: Parker, J.S.
name: Frank, J.S.
name: Pearlstein, M.V.
name: Googe, P.B.
name: Zedek, D.C.
name: Edmiston, S.N.
name: Scott, G.A.
Publisher: name: Cell Press
Year: 2019

description: Telomerase reverse transcriptase (TERT) promoter mutations are commonly found in malignant melanomas but rare in melanocytic nevi. To assess its potential diagnostic utility for the distinction of melanoma from nevus, we determined the TERT promoter mutation status of 86 primary melanomas, 72 melanocytic nevi, and 40 diagnostically problematic melanocytic proliferations. Of the 86 melanomas, 67 (77.9%) were TERT-positive, defined as harboring a hotspot TERT promoter mutation at positions -124C>T, -124_125CC>TT, -138_139CC>TT, or -146C>T. Of the 72 nevi, only 1 (1.4%) was TERT-positive. Of the 40 diagnostically uncertain melanocytic proliferations, 2 (5.0%) were TERT-positive. TERT positivity as a test for melanoma versus nevus had an accuracy of 87.3% [95% confidence interval (CI), 81.1-92.1], a sensitivity of 77.9% (95% CI, 68.9-85.4), a specificity of 98.6% (95% CI, 95.8-100), a positive predictive value of 98.5% (95% CI, 95.6-100), and a negative predictive value of 78.9% (95% CI, 72.6-85.4). Our results indicate that hotspot TERT promoter mutation status may be a useful ancillary parameter for the diagnosis of melanoma. In particular, the high specificity of these mutations for melanoma indicates the presence of a TERT promoter mutation in a melanocytic neoplasm associated with diagnostic controversy, or uncertainty should increase concern for a melanoma.
Temporal dynamics of depressive symptomatology
Creators: name: Siepe, Björn
name: Schultze, Martin
name: Reich de Paredes, Hanna
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Psychology
subject: FOS: Psychology
subject: Social and Behavioral Sciences
subject: Daily Diary
subject: Depression
subject: Time Series Analysis

description: Recent research has highlighted both the heterogeneity of depression as well as issues with generalizing results drawn from cross-sectional studies to the individual. The use of smartphones has enabled researchers to conduct experience sampling or daily diary studies to gather intensive longitudinal data about individuals. Consequently, there is a swiftly growing number of such studies that aims at investigating within-person processes with time series data. A common assumption for many models that are used within that line of research is stationarity, meaning that model parameters such as covariances or means stay constant over time. This assumption is likely to be violated in many typical psychological applications, especially in a clinical context where one is interested in change over time, for example during a treatment. Therefore, this study will analyze daily self-report data of depressed patients with a modeling technique that allows for time-varying parameters. Besides depressive symptoms, we will include other variables that have repeatedly been hypothesized to interact with depression and which are feasible to assess in daily diary studies.
A Monolayer of Primary Colonic Epithelium Generated on a Scaffold with a Gradient of Stiffness for Drug Transport Studies
Creators: name: Magness, S.T.
name: Speer, J.
name: Gunasekara, D.B.
name: Wang, Y.
name: Smiddy, N.M.
name: Allbritton, N.L.
name: Fallon, J.K.
name: Reed, M.I.
name: Smith, P.C.
name: Sims, C.E.
name: Nguyen, D.L.
name: Parker, J.S.
Publisher: name: American Chemical Society
Year: 2018

description: Animal models are frequently used for in vitro physiologic and drug transport studies of the colon, but there exists significant pressure to improve assay throughput as well as to achieve tighter control of experimental variables than can be achieved with animals. Thus, development of a primary in vitro colonic epithelium cultured as high resistance with transport protein expression and functional behavior similar to that of a native colonic would be of enormous value for pharmaceutical research. A collagen scaffold, in which the degree of collagen cross-linking was present as a gradient, was developed to support the proliferation of primary colonic cells. The gradient of cross-linking created a gradient in stiffness across the scaffold, enabling the scaffold to resist deformation by cells. mRNA expression and quantitative proteomic mass spectrometry of cells growing on these surfaces as a monolayer suggested that the transporters present were similar to those in vivo. Confluent monolayers acted as a barrier to small molecules so that drug transport studies were readily performed. Transport function was evaluated using atenolol (a substrate for passive paracellular transport), propranolol (a substrate for passive transcellular transport), rhodamine 123 (Rh123, a substrate for P-glycoprotein), and riboflavin (a substrate for solute carrier transporters). Atenolol was poorly transported with an apparent permeability (Papp) of < 5 × 10-7 cm s-1, while propranolol demonstrated a Papp of 9.69 × 10-6 cm s-1. Rh123 was transported in a luminal direction (Papp,efflux/Papp,influx = 7) and was blocked by verapamil, a known inhibitor of P-glycoprotein. Riboflavin was transported in a basal direction, and saturation of the transporter was observed at high riboflavin concentrations as occurs in vivo. It is anticipated that this platform of primary colonic epithelium will find utility in drug development and physiological studies, since the tissue possesses high integrity and active transporters and metabolism similar to that in vivo.
Mechano-chemical spinodal decomposition: A phenomenological theory of phase transformations in multi-component, crystalline solids
Creators: name: Rudraraju, Shiva
name: Van der Ven, Anton
name: Garikipati, Krishna
Publisher: name: arXiv
Year: 2015
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We present a phenomenological treatment of diffusion-driven martensitic phase transformations in multi-component crystalline solids that arise from non-convex free energies in mechanical and chemical variables. The treatment describes diffusional phase transformations that are accompanied by symmetry breaking structural changes of the crystal unit cell and reveals the importance of a mechano-chemical spinodal, defined as the region in strain-composition space where the free energy density function is non-convex. The approach is relevant to phase transformations wherein the structural order parameters can be expressed as linear combinations of strains relative to a high-symmetry reference crystal. The governing equations describing mechano-chemical spinodal decomposition are variationally derived from a free energy density function that accounts for interfacial energy via gradients of the rapidly varying strain and composition fields. A robust computational framework for treating the coupled, higher order diffusion and nonlinear strain gradient elasticity problems is presented. Because the local strains in an inhomogeneous, transforming microstructure can be finite, the elasticity problem must account for geometric nonlinearity. An evaluation of available experimental phase diagrams and first-principles free energies suggests mechano-chemical spinodal decomposition should occur in metal hydrides such as ZrH$_{2-2c}$. The rich physics that ensues is explored in several numerical examples in two and three dimensions and the relevance of the mechanism is discussed in the context of important electrode materials for Li-ion batteries and high temperature ceramics.
description: Published in Nature npj Computational Materials. Movies listed in the supplementary information available in the "Supplementary Information" section under: http://www.nature.com/articles/npjcompumats201612
D4.1 Synthesis of findings on the impact of institutional frameworks from the set of 15 case studies UPDATED
Creators: name: Kamperman, Anselm
name: Nunes Chaib, André
Publisher: name: Zenodo
Year: 2024

description: This report looks at the impact of institutional frameworks (domestic laws, European Union legislation, and international agreements) in the 15 case studies (CS) and aims at synthesizing the related learnings therefrom.

The CS reports show variety in terms of completeness and detail of analysis on legal and institutional matters, also reflect the ongoing CS work and the differences in CS focus concerning analysis methods and empirical settings. To a variable degree, CS reports focus on international trade, domestic law, supply chain organization, competition, food production, investment and social and environmental sustainability questions. In other words, the CS reports vary in terms of in-depth consideration of legal, governance and institutional aspects.

Furthermore, several areas of law, such as international environmental law and human rights law, have received especially little CS coverage. Also, other areas of law related to intellectual property (IP) are receiving little attention, particularly concerning patents, trademarks, copyrights, and geographical indications. This is remarkable since such areas of law are related to competition and innovation issues and may be especially relevant in the future agricultural trade and sustainability nexus, considering also the forthcoming transition pathways analysis (WP5).

The report provides a synthesis of general findings and based on current information, a dedicated focus for every CS.
How wide is the gap? Comparing geography graduates’ labor market success with that of peers from business and computer science
Creators: name: Teichert, Christian
name: Liefner, Ingo
name: Otto, Anne
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: With growing numbers of university graduates, the choice of academic programs has gained in importance to enter the labor market successfully. Simultaneously, the link between the field of study and actual professional career is becoming increasingly blurry. This paper aims to contribute to a better understanding of these relations and to position geography in this wide spectrum. We develop a conceptual framework to systematically categorize the relations between academic programs and their associated labor markets. We employ this framework in a most-different-case design to quantitatively analyze the influence of the field on the graduates’ career prospects, using student records of several German universities linked with administrative biographical data from social security records. We find evidence that the influence of the field of study on full-time employment and wage is substantial, controlling for various factors. Geographers do face difficulties on the labor market, but the demand for their core competencies – interdisciplinary, spatially specific and sustainability-related thinking – is rising through current societal developments. Moreover, we find some indication that those performance gaps are not an exceptional phenomenon of geographers but also apply to graduates of different fields of study with multidimensional and indirect links to the associated labor markets.
LCCC 1025: a phase II study of everolimus, trastuzumab, and vinorelbine to treat progressive HER2-positive breast cancer brain metastases
Creators: name: Anders, C.K.
name: Nabell, L.
name: Zagar, T.M.
name: Shah, N.
name: Patel, N.
name: Dees, E.C.
name: Fisher, J.
name: Jolly, T.
name: Van Swearingen, A.E.D.
name: Hoyle, A.
name: Little, P.
name: Miller, C.R.
name: Jo, H.
name: Deal, A.M.
name: Abramson, V.
name: Carey, L.A.
name: Smith, J.K.
name: Dillon, P.
name: Nanda, R.
name: Hayes, D.N.
name: Muss, H.
name: Siegel, M.B.
name: Parker, J.S.
name: Sambade, M.J.
Publisher: name: Springer New York LLC
Year: 2018

description: Purpose: HER2 + breast cancer (BC) is an aggressive subtype with high rates of brain metastases (BCBM). Two-thirds of HER2 + BCBM demonstrate activation of the PI3K/mTOR pathway driving resistance to anti-HER2 therapy. This phase II study evaluated everolimus (E), a brain-permeable mTOR inhibitor, trastuzumab (T), and vinorelbine (V) in patients with HER2 + BCBM. Patients and methods: Eligible patients had progressive HER2 + BCBM. The primary endpoint was intracranial response rate (RR); secondary objectives were CNS clinical benefit rate (CBR), extracranial RR, time to progression (TTP), overall survival (OS), and targeted sequencing of tumors from enrolled patients. A two-stage design distinguished intracranial RR of 5% versus 20%. Results: 32 patients were evaluable for toxicity, 26 for efficacy. Intracranial RR was 4% (1 PR). CNS CBR at 6 mos was 27%; at 3 mos 65%. Median intracranial TTP was 3.9 mos (95% CI 2.2–5). OS was 12.2 mos (95% CI 0.6–20.2). Grade 3–4 toxicities included neutropenia (41%), anemia (16%), and stomatitis (16%). Mutations in TP53 and PIK3CA were common in BCBM. Mutations in the PI3K/mTOR pathway were not associated with response. ERBB2 amplification was higher in BCBM compared to primary BC; ERBB2 amplification in the primary BC trended toward worse OS. Conclusion: While intracranial RR to ETV was low in HER2 + BCBM patients, one-third achieved CNS CBR; TTP/OS was similar to historical control. No new toxicity signals were observed. Further analysis of the genomic underpinnings of BCBM to identify tractable prognostic and/or predictive biomarkers is warranted. Clinical Trial: (NCT01305941).
Age-abundance relationships for neutral communities
Creators: name: Danino, Matan
name: Shnerb, Nadav M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: FOS: Biological sciences

description: Neutral models for the dynamics of a system of competing species are used, nowadays, to describe a wide variety of empirical communities. These models are used in many situations, ranging from population genetics and ecological biodiversity to macroevolution and cancer tumors. One of the main issues discussed within this framework is the relationships between the abundance of a species and its age. Here we provide a comprehensive analysis of the age-abundance relationships for fixed-size and growing communities. Explicit formulas for the average and the most likely age of a species with abundance $n$ are given, together with the full probability distribution function. We further discuss the universality of these results and their applicability to the tropical forest community.
Network Services Anomalies in NFV: Survey, Taxonomy, and Verification Methods
Creators: name: Zoure, Moubarak
name: Ahmed, Toufik
name: Réveillère, Laurent
Publisher: name: arXiv
Year: 2022
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Network Function Virtualization (NFV) has emerged as a disruptive networking architecture whose galloping evolution is prompting enterprises to outsource network functions to the cloud and ultimately harvest the fruits of cloud computing, including elasticity, pay-as-you-go billing model, and on-demand services provisioning. However, many reluctant enterprises oppose the benefits of this outsourcing to their critical and pressing concerns about security, trust, and compliance. The latter anticipate possible security and QoS policy violations stemming from dishonest behaviors by cloud providers, attacks by co-resident competitors, misconfiguration by cloud administrators, or implementations flaws by NFV developers. As a result, migrating sensitive workloads to the cloud requires enterprises to first assess risks by gaining knowledge of possible network services' anomalies and second, to build trust in the cloud by designing effective mechanisms to detect such anomalies. This survey provides scrutiny of network services anomalies that may occur in the NFV environments. We first present a taxonomy of network service anomalies and analyze their negative impacts on critical service attributes, including security and performance. Second, we compare and classify the existing anomalies' verification mechanisms from the literature. Finally, we point out the literature gap and identify future research directions for anomalies verification in NFV.
description: in IEEE Transactions on Network and Service Management
SETD2 haploinsufficiency for microtubule methylation is an early driver of genomic instability in renal cell carcinoma
Creators: name: Shuster, C.B.
name: Fahey, C.C.
name: Khan, A.
name: Karki, M.
name: Strahl, B.D.
name: Parker, J.S.
name: Tsai, Y.S.
name: Chiang, Y.-C.
name: Terzo, E.A.
name: Chowdhury, P.
name: Tripathi, D.N.
name: De Cubas, A.A.
name: Park, I.-Y.
name: Dere, R.
name: Davis, I.J.
name: Walke, C.L.
name: Sohn, B.-H.
name: Powell, R.T.
name: Rathmell, W.K.
name: Ohi, R.
name: Mason, F.M.
Publisher: name: American Association for Cancer Research Inc.
Year: 2018

description: Loss of the short arm of chromosome 3 (3p) occurs early in >95% of clear cell renal cell carcinoma (ccRCC). Nearly ubiquitous 3p loss in ccRCC suggests haploinsufficiency for 3p tumor suppressors as early drivers of tumorigenesis. We previously reported methyltransferase SETD2, which trimethylates H3 histones on lysine 36 (H3K36me3) and is located in the 3p deletion, to also trimethylate microtubules on lysine 40 (aTubK40me3) during mitosis, with aTubK40me3 required for genomic stability. We now show that monoallelic, Setd2-deficient cells retaining H3K36me3, but not aTubK40me3, exhibit a dramatic increase in mitotic defects and micronuclei count, with increased viability compared with biallelic loss. In SETD2-inactivated human kidney cells, rescue with a pathogenic SETD2 mutant deficient for microtubule (aTubK40me3), but not histone (H3K36me3) methylation, replicated this phenotype. Genomic instability (micronuclei) was also a hallmark of patient-derived cells from ccRCC. These data show that the SETD2 tumor suppressor displays a haploinsufficiency phenotype disproportionately impacting microtubule methylation and serves as an early driver of genomic instability. Significance: Loss of a single allele of a chromatin modifier plays a role in promoting oncogenesis, underscoring the growing relevance of tumor suppressor haploinsufficiency in tumorigenesis.
The Roles of Manual and non-manual Cues in Recognizing Irony in Italian Sign Language
Creators: name: Giustolisi, Beatrice
name: Mantovan, Lara
name: Panzeri, Francesca
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Science Policy

description: In a previous study, our research group investigated the expression of irony in Italian Sign Language (LIS) and suggested that specific manual and non-manual markers signaled the signer’s meaning and attitude. The present research aimed at expanding those findings by analyzing whether these markers are used in irony recognition and whether they are language-specific. We designed an experiment in which we compared recognition of ironic remarks out of context considering three groups of Italians: Deaf signers, hearing signers, and hearing non-signers. Our aim was to verify whether the manual and non-manual markers we associated with the expression of irony in LIS constitute a reliable cue to detect irony and whether these cues were accessible to signers more than to non-signers sharing the same cultural background. Although the ironic intent in LIS was accessible also to hearing non-signers, we found, among hearing participants, that knowledge of LIS does improve accuracy in recognizing ironic remarks in LIS. This suggests that signers’ facial expressions and bodily movements do not solve a purely affective function, but are grammaticalized, at least to some degree.
Dry-sliding wear of the 316L/h-BN composites produced under crack ammonia atmosphere
Creators: name: Ekkarat CHUSONG
Publisher: name: Metallurgy and Materials Science Research Institute Chulalongkorn University
Year: 2020
Subjects: 316L stainless steel
Hexagonal boron nitride
Self-lubricating composite
Hardness
Dry-sliding wear

description: Journal of Metals Materials and Minerals, 30, 2, 117-123
Current climate and latitude shape the structure of bat-fruit interaction networks throughout the Neotropical region
Creators: name: Corro, Erick J.
name: Villalobos, Fabricio
name: Lira-Noriega, Andrés
name: Guevara, Roger
name: Dáttilo, Wesley
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology

description: How ecological interactions vary across spatial and environmental gradients has received increasing attention in recent years, contributing to the revelation of the drivers of biodiversity. However, it is still unclear how the structure of ecological interactions varies across large spatial scales and which climatic factors are associated with such variation. Here, specific predictions were derived and tested to evaluate how climatic factors and latitude are associated with the structure of bat-fruit interaction networks throughout the Neotropical region. For each study site (n = 44 sites, encompassing 48 degrees of latitude), four metrics were used to describe the network structure (i.e., network size, connectance, modularity, and nestedness). In general, an increase in modularity and a decrease in connectance and nestedness was observed towards lower latitudes and in sites with lower precipitation seasonality. Moreover, plant richness within networks increased towards lower latitudes and in sites with higher annual precipitation, whereas bat richness increased at lower latitudes and in sites with lower precipitation seasonality. These findings partially confirm both energy and seasonality hypotheses and suggest that fruit-bearing plant richness and fruit availability associated with annual precipitation and precipitation seasonality can be important correlates shaping the structure of ecological interactions throughout the Neotropical region.
Keeping computational performance analysis simple: an evaluation of the NEMO BENCH test
Creators: name: Ticco, Stella V. Paronuzzi
name: Acosta, Mario C.
name: M. Castrillo
name: O.Tintó
name: K. Serradell
Publisher: name: Zenodo
Year: 2020
Subjects: NEMO code
MPI
BENCH test

description: In 2019 a non-intrusive instrumentation of the NEMO code, aimed to give information about the MPI communications cost and structure of the model, was created by E. Maisonnave and S. Masson at the LOCEAN Laboratory, in Paris. The main goal was to identify which developments have to be prioritized for the model to enhance its scalability: a new NEMO configuration, called BENCH, was specifically developed for the purpose, offering some easy way to make performance measurements, and hoping to simplify future benchmark activities related to computing efficiency. In the first part of this work we study if this configuration can actually be used as a valid tool to get insight into NEMO’s performance, and then proceed to use the BENCH test to study some of NEMO’s most known bottlenecks: I/O and thtime e north fold. Additionally, we take the chance to investigate a topic that is gaining popularity among NEMO developers: the variability of time required to perform a time step and how it influences NEMO’s performance, obtaining prescriptions on how to avoid or mitigate such behaviour.
Identification of clonal hematopoiesis mutations in solid tumor patients undergoing unpaired next-generation sequencing assays
Creators: name: Weiss, J.
name: Walko, C.M.
name: Yoder, S.J.
name: Kim, W.Y.
name: Knepper, T.C.
name: Neil Hayes, D.
name: Grilley-Olson, J.E.
name: Coombs, C.C.
name: Montgomery, N.D.
name: Mesa, T.E.
name: Bolton, K.L.
name: Soper, J.T.
name: Hayward, M.C.
name: Zehir, A.
name: Berg, J.S.
name: Parker, J.S.
name: Tan, X.
name: Balasis, M.E.
name: Gillis, N.K.
name: Padron, E.
name: Levine, R.L.
name: Patel, N.M.
name: Papaemmanuil, E.
name: Shelton Earp, H.
name: Ball, M.
name: Richards, K.L.
Publisher: name: American Association for Cancer Research Inc.
Year: 2018

description: Purpose: In this era of precision-based medicine, for optimal patient care, results reported from commercial next-generation sequencing (NGS) assays should adequately reflect the burden of somatic mutations in the tumor being sequenced. Here, we sought to determine the prevalence of clonal hematopoiesis leading to possible misattribution of tumor mutation calls on unpaired Foundation Medicine NGS assays. Experimental Design: This was a retrospective cohort study of individuals undergoing NGS of solid tumors from two large cancer centers. We identified and quantified mutations in genes known to be frequently altered in clonal hematopoiesis (DNMT3A, TET2, ASXL1, TP53, ATM, CHEK2, SF3B1, CBL, JAK2) that were returned to physicians on clinical Foundation Medicine reports. For a subset of patients, we explored the frequency of true clonal hematopoiesis by comparing mutations on Foundation Medicine reports with matched blood sequencing. Results: Mutations in genes that are frequently altered in clonal hematopoiesis were identified in 65% (1,139/1,757) of patients undergoing NGS. When excluding TP53, which is often mutated in solid tumors, these events were still seen in 35% (619/1,757) of patients. Utilizing paired blood specimens, we were able to confirm that 8% (18/226) of mutations reported in these genes were true clonal hematopoiesis events. The majority of DNMT3A mutations (64%, 7/11) and minority of TP53 mutations (4%, 2/50) were clonal hematopoiesis. Conclusions: Clonal hematopoiesis mutations are commonly reported on unpaired NGS testing. It is important to recognize clonal hematopoiesis as a possible cause of misattribution of mutation origin when applying NGS findings to a patient's care.
Gynaecology and general practitioner services utilisation by women in the age group 50 years and older
Creators: name: Krause, Laura
name: Prütz, Franziska
Publisher: name: Robert Koch-Institut
Year: 2020
Subjects: subject: UTILISATION
subject: GYNAECOLOGY
subject: GENERAL PRACTITIONER
subject: GP
subject: WOMEN
subject: GERMANY
subject: DEGS1
subject: 610 Medizin und Gesundheit

description: There are relatively few representative data on the utilisation of physician services in Germany and its influencing. Based on data from the German Health Interview and Examination Survey for Adults (DEGS1, 2008–2011), we analyse the utilisation of gynaecology and general practitioner (GP) services, with a focus on women aged 50 years and older. We compare these findings with data from the German National Health Interview and Examination Survey 1998 (GNHIES98) and, based on this and further data, discuss possible developments. Figures for seeking GP services (over 80%) are constantly high across the entire lifespan, whereas figures for gynaecology services drop with age. Around 60% of women aged 50 years and older go to a gynaecological practice at least once a year. Socioeconomic status and place of residence are important determinants for the utilisation of services. Around half of all women aged 50 years and older sought both gynaecology and GP services at least once over a one-year period. Under 10% had only been to a gynaecologist, and around one third sought GP services only. Compared to GNHIES98, figures for GP and gynaecology services were considerably higher in DEGS1, health insurance data, however, shows no increase in the use of gynaecology services between 2008 and 2018. The results highlight the need to increase awareness among GPs of the needs of middle-aged and older women for gynaecological consultation and treatment.