cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Figure S2 from Voltage-gated sodium channel gene repertoire of lampreys: gene duplications, tissue-specific expression and discovery of a long-lost gene
Creators: name: Zakon, Harold H.
name: Weiming Li
name: Pillai, Nisha E.
name: Sumanty Tohari
name: Shingate, Prashant
name: Jianfeng Ren
name: Byrappa Venkatesh
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Neuroscience
subject: Evolutionary Biology
subject: FOS: Biological sciences

description: Studies of the voltage-gated sodium (Nav) channels of extant gnathostomes have made it possible to deduce that ancestral gnathostomes possessed four voltage-gated sodium channel genes derived from a single ancestral chordate gene following two rounds of genome duplication early in vertebrates. We investigated the Nav gene family in two species of lampreys (the Japanese lamprey, Lethenteron japonicum and sea lamprey, Petromyzon marinus) (jawless vertebrates—agnatha) and compared them with those of basal vertebrates to better understand the origin of Nav genes in vertebrates. We noted six Nav genes in both lamprey species but orthology with gnathostome (jawed vertebrate) channels was inconclusive. Surprisingly, the Nav2 gene, ubiquitously found in invertebrates and believed to have been lost in vertebrates, is present in lampreys, elephant shark (Callorhinchus milii) and coelacanth (Latimeria chalumnae). Despite repeated duplication of the Nav1 family in vertebrates, Nav2 is only in single copy in those vertebrates in which it is retained, and was independently lost in ray-finned fishes and tetrapods. Of the other five Nav channel genes, most were expressed in brain, one in brain and heart, and one exclusively in skeletal muscle. Invertebrates do not express Nav channel genes in muscle. Thus, early in the vertebrate lineage Nav channels began to diversify and different genes began to express in heart and muscle.
Workshop Geschlecht und Schulerfolg
Creators: name: Beywl, Wolfgang
Publisher: name: Aargauischer Lehrerinnen- und Lehrerverband (alv)
Year: 2022
Subjects: subject: Gender
subject: Luuise
subject: 370 - Erziehung, Schul- und Bildungswesen

description: Das Amt für Volksschule des Kantons Thurgau lud kürzlich ca. 50 Personen aus Politik, pädagogischen Fachverbänden, Medizin und Psychologie zum Thema «Einfluss des Geschlechts auf den Schulerfolg» ein.
Additional file 1 of Clinical and microbiological characteristics of nosocomial, healthcare-associated, and community-acquired Klebsiella pneumoniae infections in Guangzhou, China
Creators: name: Le, Tingting
name: Wang, Ling
name: Zeng, Chaoying
name: Fu, Leiwen
name: Liu, Zhihua
name: Hu, Jing
Publisher: name: figshare
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 1: Table S1. Primer sequences of resistant genes for K. pneumoniae.
Worldwide trends in body-mass index by urban and rural place of residence
Creators: name: Bixby, Honor Ruth Heathcote
Publisher: name: Imperial College London
Year: 2018

description: More than one half of the global population lives in urban areas. Urbanisation is often implicated as a driver of the global obesity epidemic. The empirical basis for this claim, however, is often limited data in one or a small number of countries and in limited age and sex groups. My thesis aimed to systematically quantify body-mass index (BMI) trends for children, adolescents and adults in the urban and rural areas of 200 countries and territories. Data on BMI were collated, via the NCD Risk Factor Collaboration (NCD-RisC) network, from population-based surveys that measured height and weight. Data were pooled from 1,154 surveys for the analysis of trends in children and adolescents from 1990 to 2016, and 1,842 surveys for the analysis of trends in adults from 1985 to 2016. I used a Bayesian hierarchical model to estimate urban and rural population mean BMI in each country and year, by sex and age-group. In 2016, mean BMI of children and adolescents living in urban areas was higher than that of their rural peers in almost all countries. The rise in mean BMI from 1990 to 2016 was steeper among urban than among rural boys and girls in all regions, except sub-Saharan Africa and South Asia. By contrast, mean BMI of urban and rural adults in low- and middle-income regions, particularly women, converged from 1985 to 2016, driven by a steeper rise in rural areas. Sub-Saharan Africa was the exception, where urban excess grew for women. In high-income and industrialised regions there was a rural excess in mean BMI for adults in 2016. The rise in mean BMI of rural populations was the largest contributor to the overall rise in BMI in low- and middle-income regions, and the world as a whole. Whereas, the contribution of urbanisation to the rise was at most 17% across all regions. My findings thus challenge the current paradigm that urbanisation is driving the global obesity epidemic and motivate a focus on rural populations if the worldwide BMI rise is to be curtailed. The availability, affordability and accessibility of healthy versus unhealthy foods must be confronted and action taken to create environments that promote healthy diets.
Les JabesCamp : restitution des ateliers
Creators: name: Giloux, Marianne
name: Feurtet, Jean-Marie
name: Mauger Perez, Isabelle
name: Lecomte, Héloïse
name: Pierrot, Raluca
Publisher: name: Zenodo
Year: 2024

description: Journées Abes 2024

Les intervenants : Isabelle Mauger Perez, responsable du service Autorités et Référentiels ; Marianne Giloux, responsable du département Métadonnées et Services aux Réseaux ; Jean-Marie Feurtet, responsable de la formation aux réseaux ; Raluca Pierrot, responsable du service Acquisitions Documentation Electronique et Héloïse Lecomte, responsable de la Coordination Bibliographique, Abes
Epigenetic mechanisms of breast cancer risk exposures
Creators: name: Johansson, Annelie Ewa
Publisher: name: Imperial College London
Year: 2018

description: The breast cancer incidence rate is increasing and risk prediction needs to be improved. Higher lifetime oestrogen exposure is associated with increased risk, however, the mechanisms between oestrogen exposure and breast cancer development are not clear. It was hypothesised that a woman’s lifetime oestrogen exposure accumulates DNA methylation changes, detectable in blood, which can be used for risk assessment for breast cancer. An epigenome-wide association study (EWAS) of an estimated lifetime oestrogen exposure (ELEE)-model was conducted in Illumina HumanMethylation450K (HM450K) data in EPIC-Italy (n=216). A breast cancer-associated Methylation Index (MI) of ELEE, including 31 CpG-sites, was developed using HM450K data from EPIC-Italy (n=237) and the Generations Study (n=65). The MI was validated using targeted bisulphite sequencing in the Generations Study (n=440 case-control pairs), and replicated in a meta-analysis including four study cohorts. In the EWAS, 694 CpG sites were associated (Q<0.05) with ELEE. The association between the MI and breast cancer risk was validated in the Generations Study targeted sequencing data (ORQ4_vs_Q1=1.77, 95%CI 1.07-2.93, P=0.027) and replicated in the meta-analysis (ORQ4_vs_Q1=1.45, 95%CI: 1.05-2.00, P=0.024). However, the correlation between the MI and ELEE was not replicated across study cohorts. Furthermore, two mechanisms for oestrogen-induced blood DNA methylation changes were explored in lymphocyte cell-lines (LCLs): transcriptional response via the oestrogen receptors (ERs), and DNA repair response following DNA damage. No expression of the ERs was identified in the LCLs, but indications of increasing DNA damage following oestrogen-treatment. In this project, a blood DNA methylation signature for breast cancer risk was identified, however, the signature for lifetime oestrogen exposure was not validated. Further replication of the EWAS and improvements to the MI are needed to assess if an epigenetic signature in blood can be incorporated in population risk screening. Targeted prevention for high-risk women has the potential to reduce the breast cancer incidences.
Supplementary material from What drives the spatial distribution and dynamics of local species richness in tropical forest?
Creators: name: Wiegand, Thorsten
name: May, Felix
name: Kazmierczak, Martin
name: Huth, Andreas
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 10202 Biological Mathematics
subject: FOS: Mathematics
subject: Computational Biology
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: Ecology
subject: FOS: Biological sciences

description: Detailed description of the simulation model, analytical model and additional figures
Regulation of cell-type specific enhancers in mouse pluripotent stem cells
Creators: name: Bell, Emma
Publisher: name: Imperial College London
Year: 2017

description: The hundreds of different cell types in the human body arise from a single cell: the zygote. This ability is called totipotency. As a cell becomes more specialised its potency narrows, reducing the number and diversity of its daughter cells. We can derive two pluripotent stem cell populations from mouse pre- and post-implantation embryos: Embryonic Stem Cells (ESCs) and Epiblast Stem Cells (EpiSCs). These cell types respectively represent the naive and primed states of the pluripotency spectrum. A delicately balanced transcriptional network underlies ESCs and EpiSCs, capable of both preserving pluripotency, yet prepared for differentiation. Enhancers act as hubs of transcription factors to focus and promote gene expression. In 2013 Prof Rick Young’s group proposed an ostensibly novel enhancer class: Super Enhancers (SE). In contrast to mere Typical Enhancers (TE), SE purportedly recruit transcription factors at extremely high density to drive strong expression of cell-specific genes. This thesis examines the regulation and activity of Super Enhancers defined in ESCs during pluripotency maturation. To achieve this, we used an integrated, data-driven approach, analysing sequencing data pertaining to transcription factor occupancy, chromatin accessibility, epigenetic signatures, mRNA expression, and DNA-DNA interactions, to assay SE activity both in vitro and in vivo. We found that the constituent enhancers within SEs divide into two sub-populations based on whether they continue to function as primed pluripotency establishes. We termed the constituent enhancer units Persistently Unmethylated (PU) and Differentially Methylated (DM) Super Enhancelets, reflecting their CpG methylation profiles in naive and primed pluripotent cells. PU and DM enhancers harbour distinct sequence compositions, transcription factor occupancy, and epigenetic profiles. Furthermore DM exhibit a specific chromatin function for the orphan nuclear receptor ESRRB and its co-regulators. We conclude that ESC enhancers represent a heterogenous population of genetic regulatory elements, controlled by distinct transcriptional mechanisms.
Das Sensorium des Animalischen. Elektrorezeption als Forschungsfeld einer experimentell­gestalterischen und historisch­informierten Medien-­ und Designwissenschaft
Creators: name: (:Unkn) Unknown
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2020
Subjects: critical interaction design
design research
media archaeology
electroreception
aesthetic experimental system
open hardware
artistic research
transdisciplinarity
art &
science
rapid prototyping

description: Die historisch-informierte und experimentelle Gestaltung von Medientechnologien, die das Spüren, Hören und Sehen elektromagnetischer Felder ermöglichen, ist das Kernthema des Forschungsprojekts. Das Vorhaben ist dabei von den Forschungen der animalischen Elektrorezeption inspiriert, ein Forschungsfeld, das die ‘natürliche’ Wahrnehmung elektromagnetischer Felder und Wellen bei Tieren, insbesondere Fischen (z. B. der Elefantenrüsselfisch) erforscht. Das Forschungsprojekt situiert sich damit an der Schnittstelle von Biologie, Medientechnologie, experimenteller Medienpraxis und -ästhetik, Medienwissenschaft und Designforschung. Der Forschungsprozess ist zweigleisig: Einerseits soll am Critical Media Lab des Instituts Experimentelle Design- und Medienkulturen der Fachhochschule Nordwestschweiz Hochschule für Gestaltung und Kunst in Basel die Wahrnehmung elektromagnetischer Felder über eigens entwickelte künstlerisch-explorative Experimentalsysteme im Bereich der Wearable Technology erprobt und hinsichtlich ihrer Gestaltungsmöglichkeiten ausgelotet werden. Andererseits wird die Medien- und Wissensgeschichte der Elektrorezeption seit ihren Anfängen in den 1950er Jahren aufgearbeitet. Das beantragte Forschungsprojekt bildet eines der ersten Projekte im Kontext der schweizerischen Designforschung und der künstlerisch-ästhetischen Forschung, das in Kombination mit Medienarchäologie und -ökologie das Forschungsfeld des ‘Animalischen’ erschliesst. Die Forschungsergebnisse dieses Projekts, werden in einer abschliessenden Buchpublikation sowie in (ca. zwei) Artikeln in wissenschaftlichen Zeitschriften veröffentlicht. Darüber hinaus werden sie durch eine Ausstellung und einen dazugehörigen Workshop am Campus der Künste in Basel einem breiteren Fachpublikum zugänglich gemacht.
Table S2. Small mammals species captured over the irruption cycle. from Prey selection and dietary flexibility of three species of mammalian predator during an irruption of non-cyclic prey
Creators: name: Spencer, Emma E.
name: Newsome, Thomas M.
name: Dickman, Christopher R.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Environmental Science
subject: Ecology
subject: FOS: Biological sciences

description: Small mammals captured over the course of the study between June 2008 and July 2013 (n = 3820 captures), expressed as numbers of captures per 100 trap nights (trap night = 1 trap open for one night). Captures of small mammals are shown separately for each species, for each stage of the irruption cycle.
Software Development Technology Productivity – Experiment protocol
Creators: name: Almeida, Miguel
name: Trigo, António
name: Varajão, João
Publisher: name: Zenodo
Year: 2022
Subjects: experiment protocol
software development
software application creation
software application maintenance
requirements
UML
use case diagrams
DER
entity-relationship diagram
use cases
mockup

description: Experiment protocol for measuring software development technology productivity.
The impact of temporal stress and cognitive workload on prefrontal activation and technical performance in surgeons
Creators: name: Modi, Hemel
Publisher: name: Imperial College London
Year: 2018

description: Surgeons face a plethora of stressors in the operating theatre which can increase mental demands, disrupt motor and cognitive performance, and potentially jeopardise patient safety. The prefrontal cortex (PFC) plays a crucial role in modulating workload-related performance due to its role in top-down processing. Data from outside medical practice suggests that PFC activity initially scales linearly with workload, but then attenuates at excessive workload levels. However, there is limited evidence shedding light on the impact of acute intraoperative stress on the operator cognition. The purpose of this thesis is to investigate brain behaviour in surgeons during stressful conditions and determine how the workload-activation-performance relationship is affected by expertise, resilience to stress and novel surgical instrumentation (e.g. robotic surgery). The first study reveals that senior trainees exhibit greater technical performance stability under time pressure, possibly due to sustained PFC activation and greater task engagement. In contrast, junior trainees demonstrate greater performance deterioration and relative loss of PFC activation. The second study demonstrates that stable performance under temporal stress is associated with typical activation responses in the lateral PFC, whereas performance decline under time pressure is associated with deactivation or ‘inverse’ responses. The third study builds on the preceding chapters with the addition of medical decision-making scenarios as an additional stressor. Senior trainees are able to maintain task engagement and attention when faced with a single intraoperative stressor, but struggle to recruit prefrontal regions when processing both temporal and cognitive loads simultaneously which may represent a breakdown of divided attention strategies. Conversely, more junior trainees are unable to maintain prefrontal engagement even when faced with a single stressor, yet concomitant temporal and cognitive demands prompts increased prefrontal recruitment, possibly reflecting resource allocation preferences. In order to delineate how surgical technologies modulate workload-induced changes in operator cognition, the final study shows that robotic platforms enable greater prefrontal recruitment and task engagement during stressful conditions compared with the laparoscopic approach. This thesis sheds light on how acute intraoperative stress affects cortical function by delineating the neural responses that may underpin stress-related performance decline in surgery. Brain imaging has potential as an objective method of assessing stress-coping ability in surgeons and may be used as an adjunct when determining whether a surgeon is ready for independent practice. Neuroimaging may also allow assessment of the impact of novel surgical technologies or training interventions to establish whether they have the desired effect on operator cognition.
Additional file 1 of Airway gene-expression classifiers for respiratory syncytial virus (RSV) disease severity in infants
Creators: name: Wang, Lu
name: Chu, Chin-Yi
name: McCall, Matthew N.
name: Slaunwhite, Christopher
name: Holden-Wiltse, Jeanne
name: Corbett, Anthony
name: Falsey, Ann R.
name: Topham, David J.
name: Caserta, Mary T.
name: Mariani, Thomas J.
name: Walsh, Edward E.
name: Qiu, Xing
Publisher: name: figshare
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Additional file 1: Additional technical details of RNA-Seq pre-processing, predictive model developing and cross-validation, full lists of genes selected in NGSS1 and NGSS2, and some supplemental results related to CrossNorm.
Entwicklung validierter «Planer»-Personas und deren Customer Journey aus der bestehenden Schweizer Kundschaft der Taconova Group AG
Creators: name: Di Criscio, Emanuele
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2021

description: Die vorliegende Bachelorarbeit untersucht die Bedürfnisse der Zielgruppe «Planer» aus der bestehenden Schweizer Kundschaft der Taconova Group AG. Durch eine qualitative Dokumentenanalyse, einem unternehmensinternen Workshop und zahlreichen Interviews wurden Unterschiede zwischen den befragten Planern ermittelt. Daraus ergaben sich zwei Personas: «der Innovative» und «der Konventionelle». Als wesentliche Unterschiede zwischen den Personas wurden die Produktwahl, Einflussfaktoren auf die Produktwahl und die Social Media Aktivität ausgemacht. In einer zweiten Phase wurden die Customer Journeys der Personas anhand weiterer Interviews durchleuchtet. Die Planer weisen eine hohe Zufriedenheit mit den Dienstleistungen der Taconova an den verschiedenen Berührungspunkten mit dem Unternehmen auf. Einzig fehlende und ungünstig aufbereitete Datenblätter auf der Webseite wurden bemängelt. Die Ergebnisse dieser Bachelorarbeit bilden die Basis für das Ableiten von Marketing- und Verkaufsmassnahmen durch die Taconova zur Neukundengewinnung.
Business Process as a Service (BPaaS): The Smart BPaaS Design Environment
Creators: name: Woitsch, Robert
name: Hinkelmann, Knut
name: Juan Ferrer, Ana Maria
name: Yuste, Joaquin Iranzo
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2016
Subjects: Business Process as a Service
Cloud Workflow
Business and IT Alignment

description: This paper introduces the project idea of Business Processes as a Services (BPaaS) that is worked out in the H2020 project CloudSocket. Concept models and semantics are used to align domain specific business processes with executable workflows that are deployed and in production in a multi-cloud environment. The Business Process Management System Paradigm (BPMS) is requesting the functional capabilities of the so-called BPaaS Environments (i) design, (ii) allocation, (iii) execution and (iv) evaluation, which technically compose the CloudSocket Broker platform. This paper introduces first findings of aligning customers’ business needs with BPaaS cloud offerings using a model-based approach.
Investigating the effect of chronic activation of AMP-activated protein kinase in the liver
Creators: name: Williams, Jennet
Publisher: name: Imperial College London
Year: 2017

description: Obesity and its associated complications, are an increasing global problem. Non-alcoholic fatty liver disease (NAFLD), the hepatic component of the Metabolic Syndrome currently affects an estimated 25% of the world’s population, with 2% of those affected dying from a NAFLD liver related cause, such as hepatocellular cancer (HCC). AMP-activated protein kinase (AMPK), a master regulator of energy homeostasis that regulates anabolic and catabolic pathways in response to ATP depletion has received substantial attention as a therapeutic target in treatment of the Metabolic Syndrome. More recently, a growing number of studies have focussed on the role of AMPK in cancer. This study has characterised a novel, activating mutation in the γ1 subunit of AMPK (D316A). Mice which express this mutation specifically in the liver (D316-Tg) have been used to investigate the effects of chronic hepatic AMPK activation under basal conditions and in response to the metabolic stresses of hypercaloric, high fat and lipogenic, high fructose diets. D316A-Tg mice have also been crossed with mice with liver specific Phospatase and tensin homologue (Pten) loss to evaluate the role of AMPK in NAFLD related HCC. Fatty acid synthesis was reduced in hepatocytes isolated from D316A-Tg mice and these mice were protected from hepatic steatosis under lipogenic conditions. Fatty acid oxidation in hepatocytes was unaffected by increased AMPK activity and correspondingly D316A-Tg mice were not protected from hepatic lipid accumulation, following high fat feeding. Increased hepatic AMPK activity also attenuated steatohepatitis and had a marked inhibitory effect on tumourgenesis in mice with liver specific Pten loss. Further work is required to elucidate the precise role of AMPK in tumour development. However, the findings of this study suggest that activation of AMPK in the liver may inhibit NAFLD progression and tumourgenesis and support the development of pharmacological, specific AMPK activators for use in these settings.
Staging and management of primary and recurrent rectal cancer
Creators: name: Georgiou, Panagiotis
Publisher: name: Imperial College London
Year: 2018

description: Introduction: Currently in the UK, 11-14000 patients are diagnosed with rectal cancer each year sixteen percent of whom will have a locally advanced primary rectal cancer requiring exenterative pelvic surgery (extending beyond the conventional anatomic boundaries of anterior resection surgery). A further 10-20% of patients suffer local recurrence that may be amenable to exenterative surgery. The surgical management, the radiological assessment and clinical outcomes have been poorly understood and largely limited to self-reported personal series. The aim of this thesis was to evaluate surgical optimisation and staging assessment in this group of patients. Methods: The role of lateral pelvic sidewall lymphadenectomy in optimising outcomes for patients with locally advanced and recurrent rectal cancer was examined through a meta-analysis of the literature and a prospective database of patients undergoing exenterative surgery at the Royal Marsden. The safety and feasibility of exenterative surgery were evaluated using as endpoint the diagnostic accuracy of modern imaging techniques (PET-MRI fusion, diffusion weighted MRI and high resolution MRI) in this patient undergoing exenterative surgery compared to histopathology. The learning curve of exenterative surgery was evaluated using a Risk Adjusted Cumulative Sum (RA-CUSUM). Results: Extended lymphadenectomy showed no significant benefit. MRI was overall very accurate in predicting tumour invasion within the pelvic compartments (ROC0.877). Patients with invasion of the anterior above the peritoneal reflection compartment were shown to have poorer prognosis (HR=4.621, p=0.012). Diffusion weighted MRI did not improve overall accuracy. PET MR image fusion was feasible with very good diagnostic accuracy for all the compartments. Finally, a colorectal surgeon required a minimum of 14 cases under supervision to improve the morbidity following exenterative pelvic surgery for locally advanced primary and recurrent rectal cancer. Future studies: The findings need to be tested prospectively in multicentre studies to validate the results of the learning curve, staging and lymphadenectomy.
Carpal Tunnel Syndrome: An investigation of the impact of neuropathic Pain phenotype on post-operative outcome (CAPS)
Creators: name: Kennedy, Donna
Publisher: name: Imperial College London
Year: 2018

description: This study investigated the association of neuropathic pain phenotype including median nerve somatosensory function, conditioned pain modulation (CPM), pain parameters, and psycho-social state with outcome of surgery for carpal tunnel syndrome (CTS). Methods: With ethical approval (14/LO/36) and consent, this prospective observational study recruited patients from two London hospitals. Measures prior to, 3 and 6 months post-surgery included quantitative sensory testing (QST), CPM, pain parameters, insomnia, catastrophising and mood. Pain in median nerve distribution with electrophysiologically confirmed compression and DN4 score ≥ 4 was defined as neuropathic. Primary outcome was patient-rated change at 6 months; “worse” or “no change” dichotomised as poor outcome; “slightly better”, “much better” or “completely cured” good outcome. Two additional studies recruited healthy volunteers for QST and CPM reference data. Results: Seventy-six participants were included. At baseline, 75% had neuropathic pain, 25% had sensory loss to thermal stimuli, 59% to mechanical stimuli, 16% gain to mechanical stimuli. CPM inhibition was seen in 17%. 33% had high levels of pain catastrophisation, 64% had clinical insomnia. At 3 months post-surgery there was significant improvement in QST, pain parameters, psychosocial and quality of life measures; change thereafter was not significant. At 6 months QST showed recovering thermal and mechanical function (p<0.001) but persisting mechanical hyperalgesia (p>0.05). CPM was not restored and did not correlate with outcome (p=0.85). Pain catastrophising diminished (p<0.001), scores improved for insomnia (p<0.001), anxiety (p=0.02), symptom and pain severity (p<0.001) but not depression (p=0.42). Surgical outcome was good in 92% of participants, poor in 8%. Baseline pain catastrophizing, anxiety, pain interference and functional severity correlated with outcome (p≤0.05). Conclusion: Sensory profiles pre and post-surgery correlated with symptom severity however baseline sensory profile was not associated with post-surgical symptom severity. In patients with CTS, pain catastrophizing, anxiety, pain interference and functional severity scores at baseline correlated with patient-rated outcome.
Perspectives of Latina and Non-Latina White Women on Barriers and Facilitators to Exercise in Pregnancy
Creators: name: Marquez, David
name: Bustamante, Eduardo
name: Bock, Beth C
name: Markenson, Glenn
name: Tovar, Alison
name: Chasan-Taber, Lisa
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: Uncategorized

description: Exercise during pregnancy has been associated with reduced risk of gestational diabetes mellitus, however, twice as many women are sedentary during pregnancy as compared to when they are not pregnant. We conducted 3 focus groups among 20 pregnant Latina and non-Latina white women to identify barriers and facilitators to exercise in pregnancy to inform a gestational diabetes mellitus intervention study. Quantitative analyses of demographic data, and qualitative analyses of focus groups were conducted. Women identified physical limitations and restrictions, lack of resources, energy, and time as powerful exercise barriers. Social support, access to resources, information, proper diet, scheduling, and the weather were identified as powerful facilitators. Intervention programs designed for pregnant women should facilitate social support, provide information and resources, as well as promote short-term and long-term benefits.
Figure S1. Small mammals captured over the irruption cycle. from Prey selection and dietary flexibility of three species of mammalian predator during an irruption of non-cyclic prey
Creators: name: Spencer, Emma E.
name: Newsome, Thomas M.
name: Dickman, Christopher R.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Environmental Science
subject: Ecology
subject: FOS: Biological sciences

description: Small mammals captured over the course of the study between June 2008 and July 2013 (n = 3820 captures). Expressed as numbers of captures per 100 trap nights (trap night = 1 trap open for one night). Captures of all species of small mammals are aggregated.
HPV infection, cervical carcinogenesis and the reproductive impact of local treatment for cervical preinvasive and early invasive disease
Creators: name: Mitra, Anita
Publisher: name: Imperial College London
Year: 2018

description: Background The human papillomavirus (HPV) infects the majority of sexually-active women, yet it is unclear how this highly-prevalent virus causes cervical intraepithelial neoplasia (CIN) and cervical cancer in only a minority of women. Cervical screening programmes exist to detect and treat high-grade CIN to the reduce risk of invasive cancer development, although may be associated with adverse reproductive and obstetric outcomes. Aims Firstly, this thesis aimed to test the hypothesis that the vaginal microbiome and innate immune factors (antimicrobial peptides and cytokines) are altered in CIN compared to healthy controls, and that the microbiome composition plays a role in disease outcomes. Secondly, it aimed to summarise, critically appraise and meta-analyse the current literature on adverse reproductive outcomes after treatment for CIN, and to test the hypothesis that treatment impacts on microbiome structure and innate mucosal immunity. Results 16s rRNA sequencing was used to characterise the vaginal microbiome of women with CIN and revealed increasing diversity with decreasing Lactobacillus spp. levels with increased disease severity compared to healthy controls, which in a longitudinal study of women with untreated CIN2 was associated with slower regression and greater rates of persistence. Levels of proinflammatory cytokines and antimicrobial peptides quantified using enzyme-linked immunosorbent assay were higher in high-grade CIN compared to controls. Meta-analysis demonstrated that treatment did not affect fertility, but was associated with higher rates of second-trimester miscarriage. There was heterogeneity in the literature regarding the link between treatment and preterm birth which was shown to be partly explained by choice of control group. There was a positive correlation between preterm birth risk and amount of tissue excised. The altered vaginal microbiome and proinflammatory environment persisted after successful excision, and levels of antimicrobial peptides were lower than in untreated controls. Discussion These results suggest the vaginal microbiome and innate immune factors are altered in CIN and may play a role in disease outcomes. Whilst the degree of cervical structural deficit impacts on risk of adverse reproductive outcomes an altered microbiome structure and innate mucosal immune factors likely also play a role.
BIM: Normierung und Anwendungshilfen - Fixstern am Geomatik-Himmel
Creators: name: Huber, Manfred
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2018
Subjects: BIM
SIA2051
Normierung

description: • Verständigung tut not. • SIA 2051: Die Verständigungsnorm für BIM und GIS. • SIA Dokumentationen als Anwendungshilfe. • SIA-Form Kurse als Unterstützung. • EN Normen sind für die Schweiz verpflichtend. • ISO Normen können zu EN Normen werden. • Nur wer sich aktiv, persönlich und vor Ort einbringt kann wirklich einen Beitrag leisten.
The impact of cognitive task analysis in orthopaedic trauma and knee surgery simulation training
Creators: name: Bhattacharyya, Rahul
Publisher: name: Imperial College London
Year: 2018

description: Background: Virtual reality and cadaveric simulation are expensive and not readily accessible. Innovative and accessible training adjuncts are required to help meet training needs. Cognitive Task Analysis (CTA) has been used extensively to train pilots and in other surgical specialties. However, the use of CTA’s within orthopaedics is in its infancy. Aim: The aim of this thesis was to evaluate the effectiveness of CTA to train novices in femoral intramedullary nailing and diagnostic knee arthroscopy. Methods: Design - A modified Delphi technique was used from three expert orthopaedic surgeons to design a Generic Cognitive Task Analysis (GCTA) Wizard tool. This tool was used to generate a femoral intramedullary nailing CTA tool. A similar technique was employed to design a CTA tool on diagnostic knee arthroscopy. The format of these CTA tools allowed the use of written and audio-visual modalities simultaneously to learn each phase of the surgical procedure. Validation – A Randomized Controlled Trial (RCT) was undertaken with novice undergraduate medical students. They were randomized into two equal groups using either the CTA learning tool or a standard operative technique manual. Assessment was undertaken using the validated Touch Surgery TM assessment tool on femoral intramedullary nailing. A separate RCT was undertaken with junior orthopaedic trainees who were novices in diagnostic knee arthroscopy. They were assessed on a high fidelity phantom limb simulator using the validated ASSET global rating scale. Results: The post test results analysis showed that the intervention group using the femoral nailing CTA tool significantly outperformed the control group. Similarly, the group using the knee arthroscopy CTA tool had significantly higher ASSET scores compared to the control group. Conclusions: This research designed the first CTA learning tools in orthopaedic training. They demonstrated significant objective benefits to train novices in femoral intramedullary nailing and diagnostic knee arthroscopy.
Supplementary Materials, Methods, and Results; Figs. S1 to S5; Tables S1 to S12 from The influence of stress hormones and aggression on cooperative behaviour in subordinate meerkats
Creators: name: Dantzer, Ben
name: Goncalves, Ines Braga
name: Spence-Jones, Helen C.
name: Bennett, Nigel C.
name: Heistermann, Michael
name: Ganswindt, Andre
name: Dubuc, Constance
name: Gaynor, David
name: Manser, Marta B.
name: Clutton-Brock, Tim H.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 60801 Animal Behaviour

description: In cooperative breeders, aggression from dominant breeders directed at subordinates may raise subordinate stress hormone (glucocorticoid) concentrations. This may benefit dominants by suppressing subordinate reproduction but it is uncertain whether aggression from dominants can elevate subordinate cooperative behaviour, or how resulting changes in subordinate glucocorticoid concentrations affect their cooperative behaviour. We show here that the effects of manipulating glucocorticoid concentrations in wild meerkats (Suricata suricatta) on cooperative behaviour varied between activities as well as between the sexes. Subordinates of both sexes treated with a glucocorticoid receptor antagonist (mifepristone) exhibited significantly more pup protection behaviour (babysitting) compared to those treated with glucocorticoids (cortisol) or controls. Females treated with mifepristone had a higher probability of exhibiting pup food provisioning (pupfeeding) compared to those treated with cortisol. In males, there were no treatment effects on the probability of pupfeeding, but those treated with cortisol gave a higher proportion of the food they found to pups than those treated with mifepristone. Using 19 years of behavioural data, we also show that dominant females did not increase the frequency with which they directed aggression at subordinates at times when there is need for assistance was highest. Our results suggest that it is unlikely that dominant females manipulate the cooperative behaviour of subordinates through the effects of aggression on their glucocorticoid levels and that the function of aggression directed at subordinates is probably to reduce the probability they will breed.
Additional file 1 of Targeting of G-protein coupled receptor 40 alleviates airway hyperresponsiveness through RhoA/ROCK1 signaling pathway in obese asthmatic mice
Creators: name: Lin, Xixi
name: Wang, Like
name: Lu, Xiaojie
name: Zhang, Yuanyuan
name: Zheng, Rongying
name: Chen, Ruijie
name: Zhang, Weixi
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1: Fig. S1. Effects of GPR40 inhibition on airway inflammation in asthmatic mice. (A) The number of total inflammatory cells in BALFs were calculated, and a minimum of 200 cells were employed to classify eosinophils (A), Neutrophils (B), macrophages (C) macrophages (D) and lymphocytes (E) after the last OVA challenge. BALFs were harvested to measure IL-4 (F), IL-13 (G) and IL-8 (H) release by ELISA. The data are expressed as the mean ± S.E.M (n=6). *P<0.05, **P<0.01 and ***P<0.001 compared with the control group, #P<0.05, ##P<0.01 and ###P<0.001 compared with the OVA group. Fig. S2. Mouse lung tissues were collected for the extraction of protein. The expression of GPR40 was measured by western blot. The data are expressed as the mean ± S.E.M (n=4). **P<0.01 compared with the control group, ##P<0.01 compared with the OVA model group.
Supplementary Table SI from Voltage-gated sodium channel gene repertoire of lampreys: gene duplications, tissue-specific expression and discovery of a long-lost gene
Creators: name: Zakon, Harold H.
name: Weiming Li
name: Pillai, Nisha E.
name: Sumanty Tohari
name: Shingate, Prashant
name: Jianfeng Ren
name: Byrappa Venkatesh
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Neuroscience
subject: Evolutionary Biology
subject: FOS: Biological sciences

description: Studies of the voltage-gated sodium (Nav) channels of extant gnathostomes have made it possible to deduce that ancestral gnathostomes possessed four voltage-gated sodium channel genes derived from a single ancestral chordate gene following two rounds of genome duplication early in vertebrates. We investigated the Nav gene family in two species of lampreys (the Japanese lamprey, Lethenteron japonicum and sea lamprey, Petromyzon marinus) (jawless vertebrates—agnatha) and compared them with those of basal vertebrates to better understand the origin of Nav genes in vertebrates. We noted six Nav genes in both lamprey species but orthology with gnathostome (jawed vertebrate) channels was inconclusive. Surprisingly, the Nav2 gene, ubiquitously found in invertebrates and believed to have been lost in vertebrates, is present in lampreys, elephant shark (Callorhinchus milii) and coelacanth (Latimeria chalumnae). Despite repeated duplication of the Nav1 family in vertebrates, Nav2 is only in single copy in those vertebrates in which it is retained, and was independently lost in ray-finned fishes and tetrapods. Of the other five Nav channel genes, most were expressed in brain, one in brain and heart, and one exclusively in skeletal muscle. Invertebrates do not express Nav channel genes in muscle. Thus, early in the vertebrate lineage Nav channels began to diversify and different genes began to express in heart and muscle.
Dragging up an exhibition: An unlikely cast of characters
Creators: name: Loomes, Amanda
name: Farkas, Rebecca
name: Oittinen, Riitta
name: Matharu, Sarah
name: Treasure, Joyce
name: Clark, Elly
name: Bedö, Viktor
Publisher: name: Axis Web
Year: 2023
Subjects: subject: collective curation
subject: collective writing
subject: dragging up an exhibition
subject: 700 - Künste und Unterhaltung

description: Dragging up an exhibition: An unlikely cast of characters Online Exhibition, 26 April - 31 May 2023 @ Axis This online exhibition was collectively dragged & conjured up by 10 participants of a 2 hour curatorial workshop run by Elly Clarke on 12 April at Axis. Everyone worked together through collective writing and re-imagining found objects brought from their homes or workspaces; finally placing these objects together as an exhibition, complete with interpretative texts. Participants joined us from the U.K., Switzerland, Belgium and India and presented each other's pieces live on zoom on 26 April to open this online show.
The quality and safety of apps for asthma and diabetes
Creators: name: Huckvale, Christopher Giles Robert
Publisher: name: Imperial College London
Year: 2015

description: Background Mobile medical apps – interactive software tools for consumer mobile devices such as smartphones – offer a novel context to support self-care by individuals with prevalent long-term conditions, such as diabetes and asthma. However, little is known about the quality and safety of available mobile medical apps, their potential to support desired health outcomes, or their acceptability to patients. The contribution of this thesis is to provide a detailed characterisation of issues of quality and safety affecting mobile medical apps for self-care that combines research, clinical and patient perspectives and to use these data to critique recent proposals from the UK National Health Services to offer self-care apps ‘on prescription’. Methods A multiple methods design to assess the state of research on mobile medical apps for self-care, appraise the quality of publicly-available apps and understand how and why individuals use mobile medical apps for self-care, using asthma and diabetes as representative long-term conditions. Results A limited research literature of moderate quality suggests modest benefits of app-supported interventions (defined as those that incorporate mobile medical apps as a major delivery mechanism) for the biochemical control of diabetes and equivalence to existing methods for asthma self-care. Evidence for cost-effectiveness is lacking. Mobile medical apps available through public stores rarely conform to guideline standards for information content or functionality and some, such as insulin dose calculators, pose a safety risk to patients. A range of motivational factors influence patient use of mobile medical apps for self-care, including concrete needs for data arising from changes in health status and the emotional consequences of greater awareness of disease state. Discussion Ubiquitous gaps in the quality of apps for self-care represent a potential challenge to healthcare professionals and policy-makers wishing to incorporate them into practice. A stratified response, which extends the principle of proportionality established in medical device regulation, is presented as a potential strategy to address these gaps while recognising resource and capacity constraints. Without such triangulation, the vision of ‘mobile medical apps on prescription’ is probably unrealistic.
Un-stroll
Creators: name: Brefin, Daniel
name: Etter, Simone
Publisher: name: Swiss Artistic Research Network (SARN)
Year: 2014
Subjects: subject: Promenadologie
subject: Strollology
subject: Raumwahrnehmung
subject: evocative listening
subject: Derivé
subject: Performance
subject: 700 - Künste, Bildende Kunst allgemein
subject: 791 - Öffentliche Darbietungen, Film, Rundfunk

description: «Un-stroll» is a guided tour through Geneva with a «Zvieri» (4 o’clock snack) in the middle of the night. The darkness swallows the view, urban everyday noises make room for less obvious sounds, most people have disappeared from the public space. «Sightseeing» becomes «sightlistening» and «mindseeing». How does our perception of space and the meaning of the urban change ? How does the attention move if expectations of place, time and significance are not fulfilled ? «Un-stroll» was selected by a jury to be part of «Parenthesis – Unconference : a space to share processes in artistic research», a 24h non-stop conference organised by the Swiss Artistic Research Network in Geneva in Mai 2014.
Robert Reutershan, Ray Whittaker, and Louis Orlando in Production of Girl Crazy, 1954
Creators: name: (:Unas)
Publisher: name: Unknown
Year: 1954
Subjects: East Hampton
Theatrical productions
Actors
Stages (Platforms)

description: This Image shows Robert Reutershan, Ray Whittaker, Louis Orlando, and two unknown performers in the production of Girl Crazy, 1954.
„Performance Gap“ in der Schweiz – Brisanz, Ursachen und Einflüsse auf die Differenz von geplantem Energiebedarf und gemessenem Verbrauch in Gebäuden
Creators: name: Struck, Christian
name: Benz, Michael
name: Dorer, Victor
name: Frei, Beat
name: Hall, Monika
name: Ménard, Martin
name: Moosberger, Sven
name: Sagerschnig, Carina
name: Oerhounig, Kistina
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2014
Subjects: Performance Gap
Bedarf und Verbrauch
Gebäudesimulation
Betriebsmonitoring

description: Traditionell beschreibt der „Performance-Gap“ die Differenz der Planungszielgrössen, z.B. Jahresenergieverbrauch und Überhitzungsstunden, zwischen Gebäudekonzept während der Planungsphase sowie gebauten und genutzten Gebäude. Diese Differenz kann erheblich sein. Besondere Brisanz erhält das Ausmass des „Performance-Gap“ bei der Planung und dem Betrieb von Null- bzw. Plusenergiegebäuden und der Gewährleistung der gewünschten Performance während des Anlagenbetriebes. Der vorliegende Beitrag thematisiert das Ausmass des „Performance-Gap“ in der Schweiz anhand von sieben dokumentierten Fallstudien. Das vorhandene Datenmaterial zeigt, dass die Gründe für den Performance-Gap vor allem in der Nutzung, Regelungstechnik und im Detailierungsgrad des genutzten Simulationsmodelles zu suchen sind. Die Review zeigt, dass es zur Gewährleistung einer ewünschten Energiebilanz auch während der Betriebsphase, drei Dinge braucht: (1) die Betrachtung der Variabilität in der Gebäudenutzung, Spezifikation und Bauqualität schon während der Planungsphase; (2) ein erweiterbares Modell des Gebäudes und der Gebäudetechnik, sowie (3) kontinuierliches Betriebsmonitoring während der Gebäudenutzung.