cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Metabolomic and Transcriptomic Signatures of Chemogenetic Heart Failure
Creators: name: Spyropoulos, Fotios
name: Sorrentino, Andrea
name: Reest, Jiska van der
name: Yang, Peiran
name: Waldeck-Weiermair, Markus
name: Steinhorn, Benjamin
name: Eroglu, Emrah
name: Saravi, Seyed Soheil Saeedi
name: Yu, Paul
name: C. Haigis, Marcia
name: Christou, Helen
name: Michel, Thomas
Publisher: name: figshare
Year: 2022
Subjects: subject: 110201 Cardiology (incl. Cardiovascular Diseases)
subject: FOS: Clinical medicine

description: Supplementary Material
Beaming neutrino and antineutrinos across the Earth to disentangle neutrino mixing parameters
Creators: name: Fargion, Daniele
name: D'Armiento, Daniele
name: Desiati, Paolo
name: Paggi, Paolo
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: A MINOS result seemed to hint a different anti-neutrino mass splitting and mixing angle with respect to the neutrino ones, offering a hint for a CPT violation in lepton sector. However more recent MINOS data reduced the neutrino-antineutrino differences leading to a narrow discrepancy almost compatible with no CPT violation, hard to be disentangled. Moreover last a few years of OPERA activity on tau appearance is still un-probed (one unique event). Both flavor muon-tau mixing, tau appearance and eventual CPT violation disentanglement need more tools to be enhanced. Atmospheric muon neutrino spectra and anisotropy in Deep Core at ten-tens GeV (yet unpublished) may test the muon-tau conversion but they can hardly reveal such last tiny MINOS CPT asymmetry. We show how the longest baseline neutrino oscillation available, crossing most of the Earth diameter, within an OPERA-like experiment from CERN (or FERMILAB) to ICECUBE-Deep Core neutrino detector at 21 GeV energy, may at best disentangle even last tiny CPT violation (within 6 sigma a year) while testing at highest rate tau-antitau appearance. We propose the muon neutrino disappearance or (for any CPT violation) the partial anti-muon appearance at the longest distances. Such a tuned detection experiment may lead to a clear and strong signature of tau or anti-tau generation (even within its neutral current noise background events): nearly one antitau or two tau a day. The tau appearance signal is above (or within) 10 sigma a year, even for 1% OPERA-like experiment. Peculiar configurations for theta_13 angle test and hierarchy neutrino mass test may also be addressed by a Deep Core-PINGU array detector observing electron neutrino shower at 6 GeV neutrino energy windows.
description: 18 pages, 23 figures; 8 Figures had minor changes: Double Fig4-5, Fig 6-7-8-9; 3 Figures are New: Final accepted version in Ap J (2012) with an addendum of a Cabibbo photo-art composition
Automatic Lesion Segmentation Using Atrous Convolutional Deep Neural Networks in Dermoscopic Skin Cancer images
Creators: name: Kaur, Ranpreet
Publisher: name: Media Design School
Year: 2024
Subjects: classificationCode: 321102
subject: Cancer diagnosis

description: Melanoma is the most dangerous and aggressive form among skin cancers, exhibiting a high mortality rate worldwide. Biopsy and histopathological analysis are standard procedures for skin cancer detection and prevention in clinical settings. A significant step in the diagnosis process is the deep understanding of the patterns, size, color, and structure of lesions based on images obtained through dermatoscopes for the infected area. However, the manual segmentation of the lesion region is time-consuming because the lesion evolves and changes its shape over time, making its prediction challenging. Moreover, it is challenging to predict melanoma at the initial stage as it closely resembles other skin cancer types that are not malignant as melanoma; thus, automatic segmentation techniques are required to design a computer-aided system for accurate and timely detection.
Three-dimensional self-assembling nanofiber matrix rejuvenates aged/degenerative human tendon stem/progenitor cells
Creators: name: Yin, Heyong
name: Strunz, Franziska
name: Yan, Zexing
name: Lu, Jiaju
name: Brochhausen, Christoph
name: Kiderlen, Stefanie
name: Clausen-Schaumann, Hauke
name: Wang, Xiumei
name: Gomes, Manuela E.
name: Alt, Volker
name: Docheva, Denitsa
Publisher: name: Universität Regensburg
Year: 2020
Subjects: subject: 3D microenvironment; Cell aging; Hydrogel; Rejuvenation; Stem/progenitor cell
subject: 610 Medizin

description: The poor healing capacity of tendons is known to worsen in the elderly. During tendon aging and degeneration, endogenous human tendon stem/progenitor cells (hTSPCs) experience profound pathological changes. Here, we explored a rejuvenation strategy for hTSPCs derived from aged/degenerated Achilles tendons (A-TSPCs) by providing three-dimensional (3D) nanofiber hydrogels and comparing them to young/healthy TSPCs (Y-TSPCs). RADA peptide hydrogel has a self-assembling ability, forms a nanofibrous 3D niche and can be further functionalized by adding RGD motifs. Cell survival, apoptosis, and proliferation assays demonstrated that RADA and RADA/RGD hydrogels support A-TSPCs in a comparable manner to Y-TSPCs. Moreover, they rejuvenated A-TSPCs to a phenotype similar to that of Y-TSPCs, as evidenced by restored cell morphology and cytoskeletal architecture. Transmission electron, confocal laser scanning and atomic force microscopies demonstrated comparable ultrastructure, surface roughness and elastic modulus of A- and Y-TSPC-loaded hydrogels. Lastly, quantitative PCR revealed similar expression profiles, as well a significant upregulation of genes related to tenogenesis and multipotency. Taken together, the RADA-based hydrogels exert a rejuvenating effect by recapitulating in vitro specific features of the natural microenvironment of human TSPCs, which strongly indicates their potential to direct cell behaviour and overcome the challenge of cell aging and degeneration in tendon repair.
Strategies for improving the efficiency of quantum Monte Carlo calculations
Creators: name: Lee, R. M.
name: Conduit, G. J.
name: Nemec, N.
name: Rios, P. Lopez
name: Drummond, N. D.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: We describe a number of strategies for minimizing and calculating accurately the statistical uncertainty in quantum Monte Carlo calculations. We investigate the impact of the sampling algorithm on the efficiency of the variational Monte Carlo method. Our finding that a relative time-step ratio of 1:4 is optimal in DMC is in agreement with the result of [J. Vrbik and S.M.Rothstein, Intern. J. Quantum Chem. 29, 461-468 (1986)]. Finally, we discuss the removal of serial correlation from data sets by reblocking, setting out criteria for the choice of block length and quantifying the effects of the uncertainty in the estimated correlation length.
description: 12 pages, 5 figures
Workflows zur Bereitstellung von Zeitschriftenartikeln auf Open-Access-Repositorien - Herausforderungen und Lösungsansätze
Creators: name: Vierkant, Paul
name: Siegert, Olaf
name: Deinzer, Gernot
name: Gebert, Agathe
name: Herbstritt, Marc
name: Pampel, Heinz
name: Tobias, Regine
name: Wagner, Alexander
Publisher: name: Universität Regensburg
Year: 2017
Subjects: subject: 020 Bibliotheks- und Informationswissenschaft

description: Eine zunehmende Anzahl von Zeitschriftenaufsätzen deutscher Wissenschaftseinrichtungen ist im Sinne des Open Access frei verfügbar. Die Open-Access-Verfügbarkeit kann dabei durch Anwendung verschiedener Geschäfts- und Finanzierungsmodelle umgesetzt werden. Wie aber stellen Wissenschaftseinrichtungen sicher, dass auch diejenigen Publikationen, die auf dem Goldenen Weg des Open Access publiziert werden, dauerhaft und in strukturierter Form auf Repositorien bereitgestellt werden? Wie könnte ein dafür idealtypischer Publikationsprozess aussehen? Im Rahmen dieses Artikels werden zentrale Herausforderungen beschrieben und Lösungsansätze für die Zugänglichmachung von Open-Access-Zeitschriftenartikeln auf Repositorien zusammengestellt.
Exercise to reverse frailty in older females
Creators: name: Bray, Nicholas Walter
Publisher: name: University of British Columbia
Year: 2017

description: The risk of becoming frail increases with age. One million Canadians are frail, placing them at greater risk for disease and disability. Frailty is easily observed yet difficult to define. No gold-standard definition exists, but most clinicians support frailty as a medical syndrome characterized as a state of mild to severe vulnerability. Sex-differences complicate frailty; females experience this syndrome sooner yet paradoxically live longer than males. Exercise might be an effective therapy for frailty; however, which components are most effective is yet unknown. This study hypothesized: 1) More individuals in an exercise (EX) intervention would reverse frailty, versus a control (CON) group; and 2) Changes in frailty would be related to improvement in functional task performance and measures of strength. Female participants 65-81 years of age, classified as pre-frail as determined by a score of; 1-2 on the Cardiovascular Health Study-Frailty Phenotype (FP) tool or 4-6 on the Clinical Frailty Scale (CFS) or a normal gait speed (GS) between 1.0-1.5 m/sec. The EX group (n = 9) completed a 12-week exercise intervention (3 days/week, 60 min/session). Exercise included multi-component training (MCT), inclusive of aerobic, flexibility, resistance and balance training, with a focus on the latter two modalities. The CON group (n = 11) maintained their normal daily routine. According to the FP, CFS and GS, 25, 37.5 and 62.5% more EX group participants reversed frailty status than the CON group, respectively. There was a statistically significant improvement in GS (0.24 m/sec), grip strength (3.9 kg) and sit-to-stand (STS) time (5.0 sec) within the EX group from baseline to follow-up. STS was faster in the CON group at baseline but no significant between-group difference existed at follow-up. There was also a statistically significant improvement in knee extension isometric torque (7.4 Nm) and isotonic velocity (37.5 º/sec) within the EX group from baseline to follow-up. Elbow flexion isotonic velocity was faster (40.8 º/sec) in the EX group at follow-up but no significant between-group difference existed at baseline. A MCT intervention that utilizes progressive resistance and balance exercise may be safe and effective at reversing frailty in pre-frail females.
Gaze Behavior in Social Fear Conditioning: An Eye-Tracking Study in Virtual Reality
Creators: name: Reichenberger, Jonas
name: Pfaller, Michael
name: Mühlberger, Andreas
Publisher: name: Universität Regensburg
Year: 2020
Subjects: subject: social anxiety disorder, social fear conditioning, vigilance-avoidance hypothesis, eye-tracking, virtual reality
subject: 150 Psychologie

description: The vigilance-avoidance hypothesis of selective attention assumes that socially anxious persons initially direct their attention toward fear-related stimuli and subsequently avoid these social stimuli to reduce emotional distress. New technical developments provide tools to implicit measure overt attention on fear-related stimuli via eye-tracking in ecological valid virtual environments presented via a head-mounted display. We examined in 27 low (LSA) and 26 high socially anxious (HSA) individuals fear ratings, physical behavior (duration of approach), hypervigilance (time to first fixation), and attentional avoidance (count of fixations) toward virtual female and male agents (CS) during social fear conditioning (SFC) and extinction in virtual reality (VR). As hypothesized, generally SFC was successfully induced and extinguished concerning the fear ratings. Our findings partly support the vigilance-avoidance hypothesis as HSA directed especially at the first half of the fear acquisition their initial attention more at CS+ than CS− agents, and avoided subsequently the CS+ more than the CS− agents during the fear acquisition. In contrast, in LSA participants initial and sustained attention did not differ between CS+ and CS− agents during fear acquisition. We conclude that HSA individuals guide their initial attention to emotionally threatening stimuli and subsequently avoid the threatening stimuli to possibly reduce their emotional distress, whereas LSA individuals regulate themselves less in their (fear) responses during SFC. Measuring implicit gaze behavior within a well-controlled virtual environment is an interesting innovative tool to in deeply investigate the impact of attention on emotional learning processes.
W/Z Bremsstrahlung as the Dominant Annihilation Channel for Dark Matter
Creators: name: Bell, Nicole F.
name: Dent, James B.
name: Jacques, Thomas D.
name: Weiler, Thomas J.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Dark matter annihilation to leptons, $χχ\rightarrow l \bar{l}$, is necessarily accompanied by electroweak radiative corrections, in which a W or Z boson is radiated from a final state particle. Given that the W and Z gauge bosons decay dominantly via hadronic channels, it is thus impossible to produce final state leptons without accompanying protons, antiprotons, and gamma rays. Significantly, while many dark matter models feature a helicity suppressed annihilation rate to fermions, radiating a massive gauge boson from a final state fermion removes this helicity suppression, such that the branching ratios Br(l νW), Br(l^+l^- Z), and Br(ν\nubar Z) dominate over Br(l\bar{l}). W/Z-bremsstrahlung thus allows indirect detection of many WIMP models that would otherwise be helicity-suppressed, or v^2 suppressed. Antiprotons and even anti-deuterons become consequential final state particles. This is an important result for future DM searches. We discuss the implications of W/Z-bremsstrahlung for "leptonic" DM models which aim to fit recent cosmic ray positron and antiproton data.
description: 19 pages, 5 figures. Updated to include Erratum, and changes made to PRD version
Magnetoconductance, Quantum Hall Effect, and Coulomb Blockade in Topological Insulator Nanocones
Creators: name: Kozlovsky, Raphael
name: Graf, Ansgar
name: Kochan, Denis
name: Richter, Klaus
name: Gorini, Cosimo
Publisher: name: Universität Regensburg
Year: 2020
Subjects: subject: 530 Physik

description: Magnetotransport through cylindrical topological insulator (TI) nanowires is governed by the interplay between quantum confinement and geometric (Aharonov-Bohm and Berry) phases. Here, we argue that the much broader class of TI nanowires with varying radius—for which a homogeneous coaxial magnetic field induces a varying Aharonov-Bohm flux that gives rise to a nontrivial masslike potential along the wire—is accessible by studying its simplest member, a TI nanocone. Such nanocones allow us to observe intriguing mesoscopic transport phenomena: While the conductance in a perpendicular magnetic field is quantized due to higher-order topological hinge states, it shows resonant transmission through Dirac Landau levels in a coaxial magnetic field. Furthermore, it may act as a quantum magnetic bottle, confining surface Dirac electrons and leading to a largely interaction-dominated regime of Coulomb blockade type. We show numerically that the above-mentioned effects occur for experimentally accessible values of system size and magnetic field, suggesting that TI nanocone junctions may serve as building blocks for Dirac electron optics setups.
Academic and neuroimaging outcomes of school-based reading interventions
Creators: name: Partanen, Marita Helmi
Publisher: name: University of British Columbia
Year: 2017

description: Early intervention is important for decreasing the prevalence of reading disabilities. However, despite receiving treatment, some children continue to struggle with reading and therefore they require ongoing supports. Intensive and individualized programs may be beneficial for the lowest-performing readers, however, empirical review of intensive and individualized programs has not been widely conducted. Furthermore, there is a neurobiological basis to reading impairments. Children with poor reading skills have differences in brain function and structure when compared to typically-developing readers, and there may be changes in the brain after intervention. However, the combination of multiple reading tasks in functional brain imaging along with measures of grey and white matter structure has not been conducted previously. Therefore, the purpose of my dissertation was to evaluate the academic and neurobiological outcomes of an intensive reading program as well as to determine the predictors of reading success. In Chapter 2, poor readers receiving intensive instruction were compared to other poor readers receiving small group supports as well as to good readers not receiving additional supports. Performance on academic and cognitive measures were evaluated before and after 3 months of instruction and one year later. In Chapters 3 and 4, poor readers and good readers completed functional imaging tasks (Chapter 3) and scans of grey and white matter (Chapter 4) before and after 3 months of instruction. The results showed that students in the intensive program had improved word recognition and decoding fluency immediately after intervention and one year later. Changes after intervention were also shown in functional brain activity during a rhyming task, but not during a spelling task or in grey and white matter structures. However, baseline reading and spelling skills, brain activity in the left hemisphere, and white matter organization in the right hemisphere were associated with gains in reading skills over time. Although improvements in reading were shown, a significant gap between poor and good readers persisted in the third and fourth grades. Overall, this dissertation illustrates the importance of an intensive reading program and the need for continuing supports, and that both academic and neuroimaging measures are associated with reading outcome.
The electronic thickness of graphene
Creators: name: Rickhaus, Peter
name: Liu, Ming-Hao
name: Kurpas, Marcin
name: Kurzmann, Annika
name: Lee, Yongjin
name: Overweg, Hiske
name: Eich, Marius
name: Pisoni, Riccardo
name: Taniguchi, Takashi
name: Wantanabe, Kenji
name: Richter, Klaus
name: Ensslin, Klaus
name: Ihn, Thomas
Publisher: name: Universität Regensburg
Year: 2020
Subjects: subject: 530 Physik

description: When two dimensional crystals are atomically close, their finite thickness becomes relevant. Using transport measurements, we investigate the electrostatics of two graphene layers, twisted by θ = 22° such that the layers are decoupled by the huge momentum mismatch between the K and K′ points of the two layers. We observe a splitting of the zero-density lines of the two layers with increasing interlayer energy difference. This splitting is given by the ratio of single-layer quantum capacitance over interlayer capacitance Cm and is therefore suited to extract Cm. We explain the large observed value of Cm by considering the finite dielectric thickness dg of each graphene layer and determine dg ≈ 2.6 Å. In a second experiment, we map out the entire density range with a Fabry-Pérot resonator. We can precisely measure the Fermi wavelength λ in each layer, showing that the layers are decoupled. Our findings are reproduced using tight-binding calculations.
title: Ανάλυση και σχεδιασμός ενός MRP συστήματος στον προγραμματισμό παραγωγής σε βιομηχανία παραγωγής χαλκοσωλήνων
title: Analysis and design of a MRP system in production planning in a copper tube manufacturing industry
titleType: AlternativeTitle
Creators: name: Σταμούλη, Αικατερίνη-Μαρία
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2023
Subjects: subject: MRP
subject: Προγραμματισμός παραγωγής

description: Ο προγραμματισμός της παραγωγής είναι ένας από τους πιο συνηθισμένους χώρους όπου εφαρμόζονται μοντέλα και τεχνικές διοικητικής επιστήμης. Το πρόβλημα που προκύπτει από την αρχή είναι η ανάγκη συχνής αναθεώρησης όσον αφορά τον προγραμματισμό της παραγωγής και τη γενική διαχείριση των συστημάτων παραγωγής. Ο λόγος είναι απλός: τα συστήματα παραγωγής δεν είναι μόνο αντικείμενα επιστημονικής έρευνας, είναι συνεχώς πλούσια σε νέες ανακαλύψεις, αλλά επίσης αποδέχονται άμεσα τις συνέπειες των μεγάλων αλλαγών που συμβαίνουν στον κόσμο (κυρίως τεχνικές, αλλά και κοινωνικές, πολιτικές, οικονομικές και εμπορικές). Για να επιβιώσουν, ειδικά σε συνθήκες έντονου ανταγωνισμού, πρέπει να προσαρμοστούν σε αυτές τις αλλαγές. Ως εκ τούτου, οι τρόποι διαχείρισής τους οφείλουν να εξελιχθούν με σκοπό να ανταποκρίνονται στις νέες δομές και λειτουργίες των συστημάτων που παράγουν κάθε είδους αγορές και προμηθεύουν προϊόντα και υπηρεσίες. Οι σημαντικές διαφοροποιήσεις που έχουν επέλθει την τελευταία δεκαετία στον κόσμο έχουν επιφέρει αντίστοιχες αλλαγές στα συστήματα παραγωγής και στις μεθόδους διαχείρισής τους, καθώς έχουν δημιουργήσει καινούργιες συνθήκες και καινούργιες ανάγκες για την οργάνωση και λειτουργία τους. Το σύγχρονο επιχειρηματικό περιβάλλον χαρακτηρίζεται από συνεχώς ανανεωμένα προϊόντα, αλλά εμφανίζονται συνεχώς νέες αγορές, νέοι τρόποι πληροφόρησης και επικοινωνίας, νέα δίκτυα εφοδιασμού, νέα εργαλεία και συστήματα που υποστηρίζουν τη συντήρηση των συστημάτων παραγωγής. Στη παρούσα εργασία θα μελετηθεί η ανάλυση και ο σχεδιασμός ενός MRP συστήματος στον προγραμματισμό παραγωγής σε βιομηχανία παραγωγής χαλκοσωλήνων.
Neuropathological findings in possible normal pressure hydrocephalus: A post-mortem study of 29 cases with lifelines
Creators: name: Hänninen, Joni J.
name: Nakajima, Madoka
name: Vanninen, Aleksi
name: Hytönen, Santtu
name: Rummukainen, Jaana
name: Koivisto, Anne Maria
name: Jääskeläinen, Juha E.
name: Soininen, Hilkka
name: Sutela, Anna
name: Vanninen, Ritva
name: Hiltunen, Mikko
name: Leinonen, Ville
name: Rauramaa, Tuomas
Publisher: name: Free Neuropathology
Year: 2022

description: Aims: There are very few detailed post-mortem studies on idiopathic normal-pressure hydrocephalus (iNPH) and there is a lack of proper neuropathological criteria for iNPH. This study aims to update the knowledge on the neuropathology of iNPH and to develop the neuropathological diagnostic criteria of iNPH. Methods: We evaluated the clinical lifelines and post-mortem findings of 29 patients with possible NPH. Pre-mortem cortical brain biopsies were taken from all patients during an intracranial pressure measurement or a cerebrospinal fluid (CSF) shunt surgery. Results: The mean age at the time of the biopsy was 70±8 SD years and 74±7 SD years at the time of death. At the time of death, 11/29 patients (38%) displayed normal cognition or mild cognitive impairment (MCI), 9/29 (31%) moderate dementia and 9/29 (31%) severe dementia. Two of the demented patients had only scarce neuropathological findings indicating a probable hydrocephalic origin for the dementia. Amyloid-β (Aβ) and hyperphosphorylated τ (HPτ) in the biopsies predicted the neurodegenerative diseases so that there were 4 Aβ positive/low Alzheimer’s disease neuropathological change (ADNC) cases, 4 Aβ positive/intermediate ADNC cases, 1 Aβ positive case with both low ADNC and progressive supranuclear palsy (PSP), 1 HPτ/PSP and primary age-related tauopathy (PART) case, 1 Aβ/HPτ and low ADNC/synucleinopathy case and 1 case with Aβ/HPτ and high ADNC. The most common cause of death was due to cardiovascular diseases (10/29, 34%), followed by cerebrovascular diseases or subdural hematoma (SDH) (8/29, 28%). Three patients died of a postoperative intracerebral hematoma (ICH). Vascular lesions were common (19/29, 65%). Conclusions: We update the suggested neuropathological diagnostic criteria of iNPH, which emphasize the rigorous exclusion of all other known possible neuropathological causes of dementia. Despite the first 2 probable cases reported here, the issue of “hydrocephalic dementia” as an independent entity still requires further confirmation. Extensive sampling (with fresh frozen tissue including meninges) with age-matched neurologically healthy controls is highly encouraged.
description: Free Neuropathology, Vol. 3 (2022)
Relativistic analysis of the dielectric Einstein box: Abraham, Minkowski and total energy-momentum tensors
Creators: name: Ramos, Tomas
name: Rubilar, Guillermo F.
name: Obukhov, Yuri N.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Classical Physics (physics.class-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We analyse the "Einstein box" thought experiment and the definition of the momentum of light inside matter. We stress the importance of the total energy-momentum tensor of the closed system (electromagnetic field plus material medium) and derive in detail the relativistic expressions for the Abraham and Minkowski momenta, together with the corresponding balance equations for an isotropic and homogeneous medium. We identify some assumptions hidden in the Einstein box argument, which make it weaker than it is usually recognized. In particular, we show that the Abraham momentum is not uniquely selected as the momentum of light in this case.
Εταιρική κοινωνική ευθύνη και αποδοτικότητα οικονομικών μονάδων
Creators: name: Δόγανος, Νικόλαος
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2023
Subjects: subject: Εταιρική κοινωνική ευθύνη
subject: Αποδοτικότητα
subject: Οικονομικές μονάδες
subject: Οικονομική απόδοση
subject: Τιμή μετοχής

description: Στην σύγχρονη περίοδο στην Ελλάδα, όπως και σε πολλά ανεπτυγμένα και μη κράτη, ερευνάτε όλο και περισσότερο, η επίδραση της Εταιρικής Κοινωνικής Ευθύνης, στην οικονομική απόδοση των επιχειρήσεων. Για αυτό τον σκοπό έχουν διεξαχθεί και δημοσιευθεί σε πολλά περιοδικά, πολλές έρευνες από διάφορους μελετητές ανά τον κόσμο, για την επίδρασή της στην απόδοση των οικονομικών μονάδων, με τις απόψεις να διίστανται. Κύριος στόχος της εργασίας αυτής είναι: ο προσδιορισμός της έννοιας της Εταιρικής Κοινωνική Ευθύνης και πως αυτή μπορεί να επηρεάσει την οικονομική απόδοση των εταιρειών. Η ανάλυση θα πραγματοποιηθεί με την βοήθεια της θεωρητικής και εμπειρικής βιβλιογραφίας που υπάρχει για το θέμα, καθώς επίσης και με εμπειρική μελέτη με την μελέτη 30 θετικών ανακοινώσεων 7 εταιρειών του ελληνικού χρηματιστηρίου. Οι έρευνες που έχουν γίνει δείχνουν ως επι το πλείστον θετική σχέση, αλλά και αυτή σε διάφορες περιπτώσεις να εξαρτάται από διάφορους παράγοντες. Στο πρώτο μέρος της εργασίας θα παρουσιαστεί ένα πλαίσιο το οποίο θα προσπαθήσει να εξηγήσει την Εταιρική Κοινωνική Ευθύνη και στο δεύτερο μέρος θα παρουσιαστεί η βιβλιογραφική ανασκόπηση, η οποία θα εξετάσει την σχέση με την ΕΚΕ και της απόδοσης των επιχειρήσεων διαφόρων κλάδων και διαφορετικού μεγέθους.
Optimization of quasi-normal eigenvalues for 1-D wave equations in inhomogeneous media; description of optimal structures
Creators: name: Karabash, Illya M.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Spectral Theory (math.SP)
subject: Mathematical Physics (math-ph)
subject: Optimization and Control (math.OC)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 49R05, 49K20, 78M50, 35P25, 47A55, 47N50

description: The paper is devoted to optimization of resonances associated with 1-D wave equations in inhomogeneous media. The medium's structure is represented by a nonnegative function B. The problem is to design for a given $α\in \R$ a medium that generates a resonance on the line $α+ ı\R$ with a minimal possible modulus of the imaginary part. We consider an admissible family of mediums that arises in a problem of optimal design for photonic crystals. This admissible family is defined by the constraints $0\leq b_1 \leq B (x) \leq b_2$ with certain constants $b_{1,2}$. The paper gives an accurate definition of optimal structures that ensures their existence. We prove that optimal structures are piecewise constant functions taking only two extreme possible values $b_1$ and $b_2$. This result explains an effect recently observed in numerical experiments. Then we show that intervals of constancy of an optimal structure are tied to the phase of the corresponding resonant mode and write this connection as a nonlinear eigenvalue problem.
description: Typos are corrected
IL7-IL12 Engineered Mesenchymal Stem Cells (MSCs) Improve A CAR T Cell Attack Against Colorectal Cancer Cells
Creators: name: Hombach, Andreas A.
name: Geumann, Ulf
name: Günther, Christine
name: Hermann, Felix G.
name: Abken, Hinrich
Publisher: name: Universität Regensburg
Year: 2020
Subjects: subject: CAR T cells; MSC; adoptive cell therapy; genetic immunotherapy; IL7; IL12
subject: 610 Medizin

description: Chimeric antigen receptor (CAR) redirected T cells are efficacious in the treatment of leukemia/lymphoma, however, showed less capacities in eliminating solid tumors which is thought to be partly due to the lack of cytokine support in the tumor lesion. In order to deliver supportive cytokines, we took advantage of the inherent ability of mesenchymal stem cells (MSCs) to actively migrate to tumor sites and engineered MSCs to release both IL7 and IL12 to promote homeostatic expansion and Th1 polarization. There is a mutual interaction between engineered MSCs and CAR T cells; in presence of CAR T cell released IFN-γ and TNF-α, chronic inflammatory Th2 MSCs shifted towards a Th17/Th1 pattern with IL2 and IL15 release that mutually activated CAR T cells with extended persistence, amplification, killing and protection from activation induced cell death. MSCs releasing IL7 and IL12 were superior over non-modified MSCs in supporting the CAR T cell response and improved the anti-tumor attack in a transplant tumor model. Data demonstrate the first use of genetically modified MSCs as vehicles to deliver immuno-modulatory proteins to the tumor tissue in order to improve the efficacy of CAR T cells in the treatment of solid malignancies.
Metric deformation and boundary value problems in 2D
Creators: name: Panda, Subhasis
name: Sarkar, Tapomoy Guha
name: Khastgir, S Pratik
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: A new analytical formulation is prescribed to solve the Helmholtz equation in 2D with arbitrary boundary. A suitable diffeomorphism is used to annul the asymmetries in the boundary by mapping it into an equivalent circle. This results in a modification of the metric in the interior of the region and manifests itself in the appearance of new source terms in the original homogeneous equation. The modified equation is then solved perturbatively. At each order the general solution is written in a closed form irrespective of boundary conditions. This method allows one to retain the simple form of the boundary condition at the cost of complicating the original equation. When compared with numerical results the formulation is seen to work reasonably well even for boundaries with large deviations from a circle. The Fourier representation of the boundary ensures the convergence of the perturbation series.
description: 15 pages, 5 figures, 1 table. (New figures showing the wave functions and energy levels added. Formalism applied to both Dirichlet and Neumann boundary conditions)
title: Verlässlichkeit als Lösung?
title: Zum Einfluss interorganisationaler Kollaboration auf den Implementierungsprozess von Technologien zur Reliabilitätssicherung
titleType: Subtitle
Creators: name: Eichelbaum, Nils
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: Hochzuverlässigkeitsorganisation
subject: Service-dominant Logik
subject: kritischer Literaturreview
subject: Technologieimplementierung
subject: interorganisationale Zusammenarbeit
subject: Lösungsgeschäft
subject: 600 Technik, Medizin, angewandte Wissenschaften::650 Management, Öffentlichkeitsarbeit::650 Management und unterstützende Tätigkeiten

description: Die Einführung neuer Technologien stellt für Organisationen mit hoher Zuverlässigkeit (HROs) oder solche die danach streben (RSOs) eine erhebliche Herausforderung dar. Die vorliegende Arbeit analysiert die mit diesem Prozess verbundenen Herausforderungen, insbesondere in Hinblick auf mögliche Produktionsunterbrechungen, die Einführung neuer Arbeitslogiken und die Unsicherheit im Umgang mit neuer Technologie. In Zusam-menarbeit mit spezialisierten Partnern versuchen Organisationen, Fehler und Kontinui-tätsunterbrechungen während der Implementierung zu vermeiden. Die Arbeit fußt auf einer kritischen Literaturübersicht und untersucht 72 Forschungsbei-träge aus einer Reliabilitätsperspektive. Ziel ist die Identifikation relevanter Diskurse in der bestehenden Literatur sowie die Ableitung von Handlungsempfehlungen für die Technologieimplementierung. Die Ergebnisse deuten darauf hin, dass der Diskurs der Service-Dominant-Logic aus der Marketingforschung und die Reliabilitätsperspektive aus der Managementliteratur als kohärente Perspektiven betrachtet werden können. Diese Arbeit schlägt vor, diese Verbindung in zukünftigen Beiträgen zu überprüfen und trägt damit zur Integration von Erkenntnissen aus verschiedenen Forschungsdisziplinen bei.
A versatile cis-acting element reporter system to study the function, maturation and stability of ribosomal RNA mutants in archaea
Creators: name: Ferreira-Cerca, Sébastien
name: Knüppel, Robert
name: Kern, Michael
name: Reglin, Corinna
name: Ostheimer, Nina
name: Weiß, Matthias
name: Jüttner, Michael
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: Ribosomes and Protein Translation, RNA and RNA-protein complexes
subject: 570 Biowissenschaften, Biologie

description: General molecular principles of ribosome biogenesis have been well explored in bacteria and eukaryotes. Collectively, these studies have revealed important functional differences and few similarities between these processes. Phylogenetic studies suggest that the information processing machineries from archaea and eukaryotes are evolutionary more closely related than their bacterial counterparts. These observations raise the question of how ribosome synthesis in archaea may proceed in vivo. In this study, we describe a versatile plasmid-based cis-acting reporter system allowing to analyze in vivo the consequences of ribosomal RNA mutations in the model archaeon Haloferax volcanii. Applying this system, we provide evidence that the bulge-helix-bulge motif enclosed within the ribosomal RNA processing stems is required for the formation of archaeal-specific circular-pre-rRNA intermediates and mature rRNAs. In addition, we have collected evidences suggesting functional coordination of the early steps of ribosome synthesis in H. volcanii. Together our investigation describes a versatile platform allowing to generate and functionally analyze the fate of diverse rRNA variants, thereby paving the way to better understand the cis-acting molecular determinants necessary for archaeal ribosome synthesis, maturation, stability and function.
Steering Zitterbewegung in driven Dirac systems: From persistent modes to echoes
Creators: name: Reck, Phillipp
name: Gorini, Cosimo
name: Richter, Klaus
Publisher: name: Universität Regensburg
Year: 2020
Subjects: subject: 530 Physik

description: Although Zitterbewegung—the jittery motion of relativistic particles—was known since 1930 and was predicted in solid-state systems long ago, it has been directly measured so far only in so-called quantum simulators, i.e., quantum systems under strong control, such as trapped ions and Bose-Einstein condensates. A reason for the lack of further experimental evidence is the transient nature of wave-packet Zitterbewegung. Here, we study how the jittery motion can be manipulated in Dirac systems via time-dependent potentials with the goal of slowing down/preventing its decay or of generating its revival. For the harmonic driving of a mass term, we find persistent Zitterbewegung modes in pristine, i.e., scattering free, systems. Furthermore, an effective time-reversal protocol—the “Dirac quantum time mirror”—is shown to retrieve Zitterbewegung through echoes.
Capacity Building in Community Stakeholder Groups for Increasing Physical Activity: Results of a Qualitative Study in Two German Communities
Creators: name: Loss, Julika
name: Brew-Sam, Nicola
name: Metz, Boris
name: Strobl, Helmut
name: Sauter, Alexandra
name: Tittlbach, Susanne
Publisher: name: Universität Regensburg
Year: 2020
Subjects: subject: physical activity; men; community capacity; capacity building; setting approach; health promotion; cooperative planning; participatory approach
subject: 610 Medizin

description: Community capacity building is an essential approach for health promotion, combining a participatory approach with the view to community ownership. Little research focuses on practical capacity building strategies and monitoring. Our paper looks into involving stakeholders in facilitated group discussions as a specific strategy for fostering capacity building processes. These processes focused on physical activity (PA) promotion in two German communities (ACTION4men). Along the dimensions of capacity building suggested in literature (e.g., problem solving, resource mobilization, leadership), we implemented two participatory stakeholder groups (1/community). These groups were motivated to develop and implement PA interventions for men >50 years. For measuring capacity building processes, a semi-standardized monitoring instrument was used to document all group meetings. Additionally, we conducted semi-standardized interviews with group participants and drop-outs to capture their perspectives on capacity building. All documents were analyzed using thematic analysis. We successfully established stakeholder groups that planned and implemented a range of local measures meant to increase PA among older men. In one community, the process was sustainable, whereby the group continued to meet regularly over years. Capacity building was successful to a certain degree (e.g., regarding participation, problem assessment, and resource mobilization), but stalled after first meetings. Capacity building processes differed between the two communities in terms of leadership and sustainability. The developed interventions mainly addressed the access to organized sport courses, rather than tackling walkability or active transport. The theoretical capacity building approach was successful to develop and implement programs aimed at promoting PA. The actual capacity building processes depend upon the composition of stakeholder groups and inherent power relations.
title: The Environment in Global Sustainability Governance
title: Perceptions, Actors, Innovations
titleType: Subtitle
Creators: name: Partzsch, Lena (Ed.)
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Environment
subject: Sustainability
subject: 300 Sozialwissenschaften::300 Sozialwissenschaften, Soziologie::300 Sozialwissenschaften

description: With Agenda 2030, the UN adopted wide-ranging Sustainable Development Goals (SDGs) that integrate development and environmental agendas. This book has a unique focus on the political tensions between environmental and socio-economic objectives and advocates for a cooperative shift towards environmentally sound sustainability.
Dental care beyond BC Children’s Hospital : perspectives on the transition experience for young adults with special health care needs
Creators: name: Algahtani, Mazin
Publisher: name: University of British Columbia
Year: 2017

description: Objectives: To determine the extent to which young adults with special health care needs (YASHCN) who transitioned from care at BC Children’s Hospital Department of Dentistry (BCCH-DD) with/without the help of their caregivers were successful and satisfied in establishing a dental home and, to understand this transition process from the perspective of the dentists who care for them. Methods: This cross-sectional study sampled two populations: YASHCN or their caregiver and dental providers known to care for persons with disabilities (PWD). YASHCN: Eligible subjects (n=80) born 1996 or earlier and discharged from care at BCCH-DD were identified. Demographic variables and medical diagnosis were collected from dental records. Subjects were surveyed by telephone to determine the accessibility, satisfaction, and barriers to dental care services. Dentists: Dentists identified as providers (n=11) for PWD were surveyed to collect practice demographics, education, and knowledge related to treatment of PWD. Univariate and bivariate analysis, and thematic description interpreted the data. Results: YASHCN: forty subjects (50%) consented to participate in the telephone survey. The majority of YASHCN reported good/excellent oral health (57%), had seen a dentist in the last 12 months (70%), felt they had received what was needed (68%), and were satisfied/somewhat satisfied with the care they received (75%). Medical complexity, lack of awareness about dental needs and issues related to the transition process (poor communication, extended wait time for adult facility uptake) were reported as barriers. Dentists: Eight dentists (72%) participated in the survey. Patient cooperation, age, and severity of medical condition influenced the dentists’ decision to treat PWDs. Dentists confirmed YASHCN’s reported access difficulties and made recommendations to address personal (behavior, age), family (caregiver involvement) and system level (insurance, hospital/anesthesia access) issues. Conclusions: The majority of YASHCN/caregivers expressed satisfaction with their present dental status and dental care access. Their concerns, along with the recommendations of dental providers, should be considered in the refinement of the transition experience from BCCH-DD to adult care settings and also used to further advocate for dental care access for PWD of all ages.
Displayed equations for Galois representations
Creators: name: Lau, Eike
Publisher: name: arXiv
Year: 2010
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: The Galois representation associated to a p-divisible group over a complete noetherian normal local ring with perfect residue field is described in terms of its Dieudonné display. As a corollary we deduce in arbitrary characteristic Kisin's description of the Galois representation associated to a commutative finite flat p-group scheme over a p-adic discrete valuation ring in terms of its Breuil-Kisin module. This was obtained earlier by W. Kim by a different method.
description: 15 pages
How to Advance Legal Education for Future Public Health Professionals.
Creators: name: Chriqui, Jamie F
name: Berman, Micah L
name: Crespo, Jami
name: Tobin-Tyler, Elizabeth
name: Satchell, Tyra
name: Berner Wong, Nessia
name: Arias, Jalayne J
name: Goldberg, Daniel
name: Silverman, Ross D
name: Mason Meier, Benjamin
Publisher: name: SAGE Publications
Year: 2024

description: Recent scholarship has advocated for schools and programs
of public health (SPPHs) to move public health law from the
periphery to the core of the public health curriculum, in recognition
of law’s role as a fundamental driver of health outcomes.
1,2 The Five Essential Public Health Law
Services—developed through a transdisciplinary collaboration
of public health practitioners, researchers, advocates,
and attorneys—emphasize that competency in public health
law requires much more than the ability to summarize key
statutes or court decisions.3 Rather, “[p]eople working in
public health—whether in agencies, non-governmental organizations,
health systems, research and even biomedical sciences—
can expect to carry out a variety of functions that
involve law, frequently without the assistance or even the
involvement of lawyers.”1 These functions include the
design, development, implementation, enforcement, and
evaluation of legal interventions (to prevent drug overdoses,
ensure food safety, contain infectious disease outbreaks, and
much more)—functions that have become more complex
and politically charged, but no less important, since the onset
of the COVID-19 pandemic.
The Derivation of the Exact Internal Energies for Spin Glass Models by Applying the Gauge Theory to the Fortuin-Kasteleyn Representation
Creators: name: Yamaguchi, Chiaki
Publisher: name: arXiv
Year: 2010
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We derive the exact internal energies and the rigorous upper bounds of specific heats for several spin glass models by applying the gauge theory to the Fortuin-Kasteleyn representation which is a representation based on a percolation picture for spin-spin correlation. The results are derived on the Nishimori lines which are special lines on the phase diagrams. As the spin glass models, the +-J Ising model and a Potts gauge glass model are studied. The present solutions agree with the previous solutions. The derivation of the solutions by the present method must be useful for understanding the relationship between the percolation picture for spin-spin correlation and the physical quantities on the Nishimori line.
description: 10 pages, no figures. v3: minor corrections/additions
PPPC 4 DM ID: A Poor Particle Physicist Cookbook for Dark Matter Indirect Detection
Creators: name: Cirelli, Marco
name: Corcella, Gennaro
name: Hektor, Andi
name: Hütsi, Gert
name: Kadastik, Mario
name: Panci, Paolo
name: Raidal, Martti
name: Sala, Filippo
name: Strumia, Alessandro
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We provide ingredients and recipes for computing signals of TeV-scale Dark Matter annihilations and decays in the Galaxy and beyond. For each DM channel, we present the energy spectra of electrons and positrons, antiprotons, antideuterons, gamma rays, neutrinos and antineutrinos e, mu, tau at production, computed by high-statistics simulations. We estimate the Monte Carlo uncertainty by comparing the results yielded by the Pythia and Herwig event generators. We then provide the propagation functions for charged particles in the Galaxy, for several DM distribution profiles and sets of propagation parameters. Propagation of electrons and positrons is performed with an improved semi-analytic method that takes into account position-dependent energy losses in the Milky Way. Using such propagation functions, we compute the energy spectra of electrons and positrons, antiprotons and antideuterons at the location of the Earth. We then present the gamma ray fluxes, both from prompt emission and from Inverse Compton scattering in the galactic halo. Finally, we provide the spectra of extragalactic gamma rays. All results are available in numerical form and ready to be consumed.
description: 57 pages with many figures and tables. v4: updated to include a 125 higgs boson, computation and discussion of extragalactic spectra corrected, some other typos fixed; all these corrections and updates are reflected on the numerical ingredients available at http://www.marcocirelli.net/PPPC4DMID.html they correspond to Release 2.0