cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Effects of critical fluctuations and dimensionality on the jump in specific heat at the superconducting transition temperature: Application to YBa2Cu_3 O_7 - δ, Bi_2 Sr_2CaCu_2 O_8+δand KOs_2 O_6 compounds
Creators: name: Tsiaze, R. M. Keumo
name: Wirngo, A. V.
name: Tchouobiap, S. E. Mkam
name: Fotue, A. J.
name: Baloïtcha, E.
name: Hounkonnou, M. N.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We report on a study of the superconducting order parameter thermodynamic fluctuations in $\mathrm{YBa}_2\mathrm{Cu}_3\mathrm{O}_{7 - δ}$, $\mathrm{Bi}_{2}\mathrm{Sr}_{2}\mathrm{CaCu}_{2}\mathrm{O}_{8+ δ}$ and $\mathrm{KOs}_2\mathrm{O}_6$ compounds. A non-perturbative technique within the framework of the renormalized Gaussian approach is proposed. The essential features are reported (analytically and numerically) through Ginzburg-Landau (GL) model-based calculations which take into account both the dimension and the microscopic parameters of the system. By presenting a self-consistent approach (SCA) improvement on the GL theory, a technique for obtaining corrections to the asymptotic critical behavior in terms of non universal parameters is developed. Therefore, corrections to the specific heat and the critical transition temperature for one-, two- and three-dimensional samples are found taking into account the fact that fluctuations occur at all length scales as the critical point of a system is approached. The GL model in the free-field approximation and the 3D-XY model are suitable for describing the weak and strong fluctuation regimes respectively. However, with a modified quadratic coefficient, the renormalized GL model is able to explain certain experimental observations including the specific heat of complicated systems, such as the cuprate superconductors and the $β$-pyrochlore oxides. It is clearly shown that the enhancement, suppression or rounding of the specific heat jump of high-$T_c$ cuprate superconductors at the transition are indicative of the order parameter thermodynamic fluctuations according to the dimension and the nature of interactions.
description: arXiv admin note: text overlap with arXiv:cond-mat/0109177 by other authors
Comprehensive evaluation of the linear stability of Alfvén eigenmodes driven by alpha particles in an ITER baseline scenario
Creators: name: Figueiredo, A. C. A.
name: Rodrigues, P.
name: Borba, D.
name: Coelho, R.
name: Fazendeiro, L.
name: Ferreira, J.
name: Loureiro, N. F.
name: Nabais, F.
name: Pinches, S. D.
name: Polevoi, A. R.
name: Sharapov, S. E.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: The linear stability of Alfvén eigenmodes in the presence of fusion-born alpha particles is thoroughly assessed for two variants of an ITER baseline scenario, which differ significantly in their core and pedestal temperatures. A systematic approach is used that considers all possible eigenmodes for a given magnetic equilibrium and determines their growth rates due to alpha-particle drive and Landau damping on fuel ions, helium ashes and electrons. This extensive stability study is efficiently conducted through the use of a specialized workflow that profits from the performance of the hybrid MHD drift-kinetic code $\mbox{CASTOR-K}$ (Borba D. and Kerner W. 1999 J. Comput. Phys. ${\bf 153}$ 101; Nabais F. ${\it et\,al}$ 2015 Plasma Sci. Technol. ${\bf 17}$ 89), which can rapidly evaluate the linear growth rate of an eigenmode. It is found that the fastest growing instabilities in the aforementioned ITER scenario are core-localized, low-shear toroidal Alfvén eigenmodes. The largest growth-rates occur in the scenario variant with higher core temperatures, which has the highest alpha-particle density and density gradient, for eigenmodes with toroidal mode numbers $n\approx30$. Although these eigenmodes suffer significant radiative damping, which is also evaluated, their growth rates remain larger than those of the most unstable eigenmodes found in the variant of the ITER baseline scenario with lower core temperatures, which have $n\approx15$ and are not affected by radiative damping.
title: Ergebnisse der laparoskopischen Omentumplastik bei Poststernotomiemediastinitis
Creators: name: Hoffmann, Martin
name: Kujath, Peter
name: Zimmermann, Markus
name: Hintz, Matthias
name: Schlöricke, Erik
Publisher: name: German Medical Science GMS Publishing House
Year: 2016
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die Poststernotomiemediastinitis stellt ein schwerwiegendes Krankheitsbild mit einer hohen assoziierten Morbidität und Mortalität dar. Das Ziel der vorliegenden Untersuchung ist die Untersuchung der Ergebnisse der laparoskopischen Omentumplastik in einem Krankenhaus der Maximalversorgung.[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 133. Kongress der Deutschen Gesellschaft für Chirurgie
Deep Noise Suppression for Real Time Speech Enhancement in a Single Channel Wide Band Scenario
Creators: name: Gómez, Esteban
Publisher: name: Zenodo
Year: 2021
Subjects: Speech enhancement; Speech quality; Noise suppression; Deep learning; Real time applications

description: Speech enhancement can be regarded as a dual task that addresses two important issues of degraded speech: Speech quality and speech intelligibility. Improved speech quality can reduce listener’s fatigue, whereas improved speech intelligibility can re-duce the listener’s e˙ort to understand and extract meaning from speech. This work is focused on speech quality in a real time context. Algorithms that improve speech quality are sometimes referred to as noise suppression algorithms, since they enhance quality by suppressing the background noise of the degraded speech. Improving state of the art noise suppression algorithms could lead to significant benefits to several applications such as video conferencing systems, phone calls or speech recognition systems. Real time capable algorithms are especially important for devices with a limited processing power and physical constraints that cannot make use of large architectures, such as hearing aids or wearables. This work uses a deep learning based approach to expand on two previously proposed architectures in the context of the Deep Noise Suppression Challenge carried out by Microsoft. This challenge has provided datasets and resources to teams of researchers with the common goal of fostering the research on the aforementioned topic. The outcome of this thesis can be divided into three main contributions: First, an extended comparison between six variants of the two selected models, considering performance, computational com-plexity and real time eÿciency analyses. Secondly, making available an open source implementation of one of the proposed architectures as well as a framework transla-tion of an existing implementation. Finally, proposed variants that outperform the previously defined models in terms of denoising performance, complexity and real time eÿciency.
title: RE- TEP nach initialer TAPP/TEP zur operativen Therapie des Leistenhernienrezidivs
Creators: name: Weyhe, Dirk
name: Heinzel, Ralf
name: Tabriz, Navid
name: Uslar, Verena
name: Müller, Andreas
Publisher: name: German Medical Science GMS Publishing House
Year: 2016
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die Richtlinie der European Hernia Society empfiehlt den Wechsel der Operationsmethode nach einem Leistenhernien-Rezidiv. Als Versorgungsprinzip von Rezidivhernien ist die Anwendung eines jeweils komplimentären Verfahrens konsentiert. Unklar ist der Stellenwert des erneuten total extraperitonealen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 133. Kongress der Deutschen Gesellschaft für Chirurgie
A chip-based array of near-identical, pure, heralded single photon sources
Creators: name: Spring, Justin B.
name: Mennea, Paolo L.
name: Metcalf, Benjamin J.
name: Humphreys, Peter C.
name: Gates, James C.
name: Rogers, Helen L.
name: Soeller, Christoph
name: Smith, Brian J.
name: Kolthammer, W. Steven
name: Smith, Peter G. R.
name: Walmsley, Ian A.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Interference between independent single photons is perhaps the most fundamental interaction in quantum optics. It has become increasingly important as a tool for optical quantum information science, as one of the rudimentary quantum operations, together with photon detection, for generating entanglement between non-interacting particles. Despite this, demonstrations of large-scale photonic networks involving more than two independent sources of quantum light have been limited due to the difficulty in constructing large arrays of high-quality single photon sources. Here, we solve the key challenge, reporting a novel array of more than eighteen near-identical, low-loss, high-purity, heralded single photon sources achieved using spontaneous four-wave mixing (SFWM) on a silica chip. We verify source quality through a series of heralded Hong-Ou-Mandel experiments, and further report the experimental three-photon extension of the entire Hong-Ou-Mandel interference curves, which map out the interference landscape between three independent single photon sources for the first time.
description: 16 pages including supplementary information
Renal ultrafiltration in health and disease
Creators: name: Burne., Melissa Jean
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Life Cycle Assessment and Cost-Benefit Analysis of Internal-Stack Trickling Bio-Electrochemical Reactor: An Evaluation for commercial viability
Creators: name: Mathuriya, Abhilasha S
name: Ibrahim, Mona G.
name: Hosny, Suman Sally
name: Sonawane, Jayesh M
name: Pandit, Soumya
name: Singh, Anoop
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified

description: The present study reports a detailed life cycle assessment and cost-benefit analysis of a commercially viable Internal-Stack-Trickling Bio-Electrochemical Reactor (IS-TrickBER). IS-TrickBER used wastewater as a feedstock and converted that wastewater through electrochemical methods into low-grade fertilizer and produced electricity. IS-TrickBER was observed for its performance in terms of power output and wastewater treatment. IS-TrickBER exhibited up to 4.2 Wh net energy yield while treating 84.84L wastewater per day along with 92.17% COD removal and 38.23% Columbic efficiency during the operational run with real municipal wastewater. Based on daily net energy yield, up to 1457.6Wh yearly net energy yield can be expected. A comprehensive start-to-end life cycle assessment study associated with the manufacturing, and operational phases of IS-TrickBER was also conducted to ascertain its impact on the environment. The environmental impact through air emissions during the manufacturing stage can be minimized by changing the plastic balls used as packing material in the reactor. A detailed cost-benefit analysis was also conducted to understand its economic viability. Cost-benefit analysis of IS-TrickBER, based on net energy yield, shows that IS-TrickBER could compensate its installation cost within a few years. IS-TrickBER performed well in eliminating the chemical load of wastewater and simultaneous electricity generation. Due to its scalability, compactness, and low maintenance, IS-TrickBER can be a suitable candidate in real-time wastewater treatment.
Portfolio Optimization Problem with Non-identical Variances of Asset Returns using Statistical Mechanical Informatics
Creators: name: Shinzato, Takashi
Publisher: name: arXiv
Year: 2016
Subjects: subject: Portfolio Management (q-fin.PM)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Mathematical Physics (math-ph)
subject: FOS: Economics and business
subject: FOS: Physical sciences

description: The portfolio optimization problem in which the variances of the return rates of assets are not identical is analyzed in this paper using the methodology of statistical mechanical informatics, specifically, replica analysis. We define two characteristic quantities of an optimal portfolio, namely, minimal investment risk and concentrated investment level, in order to solve the portfolio optimization problem and analytically determine their asymptotical behaviors using replica analysis. Moreover, numerical experiments were performed, and a comparison between the results of our simulation and those obtained via replica analysis validated our proposed method.
description: 11 pages, 4 figures
Transmembrane serine protease 2 (TMPRSS2) proteolytically activates the epithelial sodium channel (ENaC) by cleaving the channel’s γ-subunit
Creators: name: Sure, Florian
name: Bertog, Marko
name: Afonso, Sara
name: Diakov, Alexei
name: Rinke, Ralf
name: Madej, M. Gregor
name: Wittmann, Sabine
name: Gramberg, Thomas
name: Korbmacher, Christoph
name: Ilyaskin, Alexandr V.
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: epithelial sodium channel (ENaC), TMPRSS2, proteolytic channel activation, two electrode voltage clamp, electrophysiology oocyte homology modeling serine protease epithelial cell H441 cell line
subject: 540 Chemie
subject: 570 Biowissenschaften, Biologie

description: The epithelial sodium channel (ENaC) is a heterotrimer consisting of α-, β- and γ-subunits. Channel activation requires proteolytic release of inhibitory tracts from the extracellular domains of α- and γ-ENaC; however, the proteases involved in the removal of the γ-inhibitory tract remain unclear. In several epithelial tissues, ENaC is coexpressed with the transmembrane serine protease 2 (TMPRSS2). Here, we explored the effect of human TMPRSS2 on human αβγ-ENaC heterologously expressed in Xenopus laevis oocytes. We found coexpression of TMPRSS2 stimulated ENaC-mediated whole-cell currents by ∼3-fold, likely due to an increase in average channel open probability. Furthermore, TMPRSS2-dependent ENaC stimulation was not observed using a catalytically-inactive TMPRSS2 mutant and was associated with fully-cleaved γ-ENaC in the intracellular and cell surface protein fractions. This stimulatory effect of TMPRSS2 on ENaC was partially preserved when inhibiting its proteolytic activity at the cell surface using aprotinin, but was abolished when the γ-inhibitory tract remained attached to its binding site following introduction of two cysteine residues (S155C – Q426C) to form a disulfide bridge. In addition, computer simulations and site-directed mutagenesis experiments indicated TMPRSS2 can cleave γ-ENaC at sites both proximal and distal to the γ-inhibitory tract. This suggests a dual role of TMPRSS2 in the proteolytic release of the γ-inhibitory tract. Finally, we demonstrated that TMPRSS2-knockdown in cultured human airway epithelial cells (H441) reduced baseline proteolytic activation of endogenously expressed ENaC. Thus, we conclude TMPRSS2 is likely to contribute to proteolytic ENaC activation in epithelial tissues in vivo.
title: Fremdkörperingestion bei einem 3-jährigen Mädchen mit operativ versorgten multiplen Dünndarmatresien
Creators: name: Lehnert, Thomas
name: Wachowiak, Robin
name: Hempel, Christoph
name: Preißler, Julia
name: Zurek, Marlen
name: Geyer, Christan Paul
Publisher: name: German Medical Science GMS Publishing House
Year: 2016
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Fremdkörperingestionen im Kindesalter sind mit zwei Altersgipfeln hervortretend: Das Kleinkindesalter, bei dem der Mund als ‚Tastorgan dient’ sowie das spätere Schulalter, wo der Mund als ‚3. Hand’ gebraucht wird. Leitsymptome sind Erbrechen, Salivation[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 133. Kongress der Deutschen Gesellschaft für Chirurgie
Protein sorting in the secretory pathway : requirements for retention of a medial-Golgi glycosyltransferase
Creators: name: Burke., Jo
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Contribution of Symptomatic, Herbal Treatment Options to Antibiotic Stewardship and Microbiotic Health
Creators: name: Nausch, Bernhard
name: Bittner, Claudia
name: Höller, Martina
name: Abramov-Sommariva, Dimitri
name: Hiergeist, Andreas
name: Gessner, Andre
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: herbal drugs; gut microbiota; antibiotic stewardship; uncomplicated infection; NSAID; homeostasis
subject: 610 Medizin

description: Epithelial surfaces in humans are home to symbiotic microbes (i.e., microbiota) that influence the defensive function against pathogens, depending on the health of the microbiota. Healthy microbiota contribute to the well-being of their host, in general (e.g., via the gut–brain axis), and their respective anatomical site, in particular (e.g., oral, urogenital, skin, or respiratory microbiota). Despite efforts towards a more responsible use of antibiotics, they are often prescribed for uncomplicated, self-limiting infections and can have a substantial negative impact on the gut microbiota. Treatment alternatives, such as non-steroidal anti-inflammatory drugs, may also influence the microbiota; thus, they can have lasting adverse effects. Herbal drugs offer a generally safe treatment option for uncomplicated infections of the urinary or respiratory tract. Additionally, their microbiota preserving properties allow for a more appropriate therapy of uncomplicated infections, without contributing to an increase in antibiotic resistance or disturbing the gut microbiota. Here, herbal treatments may be a more appropriate therapy, with a generally favorable safety profile.
Colloidal suspensions of C-particles: Entanglement, percolation and microrheology
Creators: name: Hoell, Christian
name: Löwen, Hartmut
Publisher: name: arXiv
Year: 2016
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We explore structural and dynamical behavior of concentrated colloidal suspensions made up by C-shape particles using Brownian dynamics computer simulations and theory. In particular, we focus on the entanglement process between nearby particles for almost closed C-shapes with a small opening angle. Depending on the opening angle and the particle concentration, there is a percolation transition for the cluster of entangled particles which shows the classical scaling characteristics. In a broad density range below the percolation threshold, we find a stretched exponential function for the dynamical decorrelation of the entanglement process. Finally, we study a set-up typical in microrheology by dragging a single tagged particle with constant speed through the suspension. We measure the cluster connected to and dragged with this tagged particle. In agreement with a phenomenological theory, the size of the dragged cluster depends on the dragging direction and increases markedly with the dragging speed.
description: 13 pages, 15 figures
Henderson et al ARRIVE Checklist - Full.pdf
Creators: name: Henderson, Colin
name: Wolf, C Roland
name: Kapelyukh, Yury
name: mclaren, aileen
Publisher: name: figshare
Year: 2022
Subjects: Cancer

description: ARRIVE guidelines 2.0: author checklist (full) for ‘Improving the predictive power of xenograft and syngeneic anti-tumour studies using mice humanised for pathways of drug metabolism’
Myrcia bicolor Kiaerskou 1893
Creators: name: Santos, Matheus F.
name: Sano, Paulo T.
name: Lucas, Eve
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Myrtales
Myrtaceae
Myrcia
Myrcia bicolor

description: 2. Myrcia bicolor Kiaerskou (1893: 65)
 Type:— BRAZIL. Rio de Janeiro: Floresta da Tijuca [“Brésil (Rio Jan.) Floresta da Tijuca” on label], 20 November 1878 (fl.), Glaziou 10797 (lectotype C [C 10015825]! designated here, isolectotypes BR!, C [C 10015826]!, F!, K!, LE!, NY!, P!, R!, US!). Figure 3.
 There are two sheets of Myrcia bicolor at C, both bearing the author’s handwriting (“ Myrcia (Aulomyrcia) bicolor ”). Aulomyrcia is the subgenus where the author placed the species (Kiaerskou 1893). The leaf illustrated in the protologue (Tab. V, f; Kiaerskou 1893) was drawn from the lectotype (Figure 3); a draft of the illustration is attached to the sheet. The locality present in some labels of the type collection (“Province de R. J. Floresta da Tijuca”, i.e., the Tijuca Forest in the municipality of Rio de Janeiro, Rio de Janeiro state, Brazil) matches the species distribution and is considered to be the type locality.
description: Published as part of Santos, Matheus F., Sano, Paulo T. & Lucas, Eve, 2016, Lectotypifications of some Nineteenth Century names and other nomenclatural updates in Myrcia s. l. (Myrtaceae), pp. 448-450 in Phytotaxa 257 (1) on pages 448-450, DOI: 10.11646/phytotaxa.257.1.1, http://zenodo.org/record/13671207
Biological function of human FSH and LH isoforms
Creators: name: Burgon., Patrick G.
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Minimal Investment Risk of Portfolio Optimization Problem with Budget and Investment Concentration Constraints
Creators: name: Shinzato, Takashi
Publisher: name: arXiv
Year: 2016
Subjects: subject: Portfolio Management (q-fin.PM)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Mathematical Physics (math-ph)
subject: FOS: Economics and business
subject: FOS: Physical sciences

description: In the present paper, the minimal investment risk for a portfolio optimization problem with imposed budget and investment concentration constraints is considered using replica analysis. Since the minimal investment risk is influenced by the investment concentration constraint (as well as the budget constraint), it is intuitive that the minimal investment risk for the problem with an investment concentration constraint be larger than that without the constraint (that is, with only the budget constraint). Moreover, a numerical experiment shows the effectiveness of our proposed analysis.
description: 8 pages, 1 figure
Supplementary document for Enhancement of lossy mode resonance sensing properties by introduction of an intermediate low refractive index layer - 6369194.pdf
Creators: name: Armas, Dayron
name: KWIETNIEWSKI, NORBERT
name: Matias, Ignacio
name: Burnat, Dariusz
name: Smietana, Mateusz
name: Del Villar, Ignacio
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: Uncategorized

description: Field characterization
Modelling the neurons of the electrosensory lobe in Gymnotus omarorum with differentiable programming
Creators: name: Vischia, Pietro
name: Caputi, Angel A.
Publisher: name: Zenodo
Year: 2023

description: Nervous systems are complex structures in which one can identify different organization levels, from the molecular and subcellular to those describing the whole animal behaviour. One of the challenges of present neuroscience is to understand how different organization levels influence each other, to reach a solid understanding on how the brain works. Formal computational models are powerful tools to bridge the gaps between levels. Taking into account the characteristic features observed in one level they allow to predict the behaviour of the superior level or hypothesize sets of combination factors that explain the emergence of such characteristic features. Here we present ongoing work aiming to construct a model that bridges the gap between the intrinsic properties of the neurons and the circuit behaviour of the electrosensory lobe of the weakly electric fish Gymnotus omarorum.  These fish evaluate their environment and communicate using electric images carried by electric discharges of a specialized electrogenic organ. These images are originated on the heterogeneous distribution of impedance on the fish ́s surrounds and are sensed by cutaneous electroreceptors, each of which provides local information to the electrosensory lobe through a single primary afferent fiber. The electrosensory lobe contains two independent electrosensory paths, called fast and slow somehow analogously to those observed in the auditory system. The fast path is represented by a single type of spherical neurons that receive primary afferent calixes making synaptic contact through electrical and chemical synapses and project to a mesencephalic nuclei where a Jeffress-like circuit (Jeffress, 1948) compares the latency between different incoming inputs. The slow path is represented by a cerebellum-like circuit receiving feed-forward and feed-back connections: such a circuit has two types of output neurons with different intrinsic properties and dynamical responsiveness to changes in the electrosensory image (for details on this system see Caputi et al., 2020). We focussed first on spherical cells, because their round shape and small number of afferent contacts simplify the modelling and understanding their role in the circuit. These neurons were previously characterized by intracellular recordings in vitro (Nogueira et al., 2006) and their behaviour was studied in freely moving fish (Castelló et al., 1998). Taking into account the previous data (Nogueira et al., 2011, 2014), we used the formalism introduced by Hodgkin and Huxley, including a fast Na+, two K+ currents (high and low threshold) and a mixed cation resonant current. We built a differentiable parametric simulation, and found the set of parameters values that best reproduce the experimental results obtained in vitro and the response of the fast electrosensory path in vivo by means of a gradient-descent-powered maximum likelihood fit.
A mathematical model of granulopoiesis incorporating the negative feedback dynamics and kinetics of G-CSF/neutrophil binding and internalisation
Creators: name: Craig, Morgan
name: Humphries, Antony R
name: Mackey, Michael C
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cell Behavior (q-bio.CB)
subject: Tissues and Organs (q-bio.TO)
subject: FOS: Biological sciences

description: We develop a physiological model of granulopoiesis which includes explicit modelling of the kinetics of the cytokine granulocyte colony-stimulating factor (G-CSF) incorporating both the freely circulating concentration and the concentration of the cytokine bound to mature neutrophils. G-CSF concentrations are used to directly regulate neutrophil production, with the rate of differentiation of stem cells to neutrophil precursors, the effective proliferation rate in mitosis, the maturation time, and the release rate from the mature marrow reservoir into circulation all dependent on the level of G-CSF in the system. The dependence of the maturation time on the cytokine concentration introduces a state-dependent delay into our differential equation model, and we show how this is derived from an age-structured partial differential equation model of the mitosis and maturation, and also detail the derivation of the rest of our model. The model and its estimated parameters are shown to successfully predict the neutrophil and G-CSF responses to a variety of treatment scenarios, including the combined administration of chemotherapy and exogenous G-CSF. This concomitant treatment was reproduced without any additional fitting to characterise drug-drug interactions.
A Federated Platform For Open Science
Creators: name: Becker, B
name: Barbera, R
Publisher: name: Sci-GaIA Open Access Repository
Year: 2016

description: Access to relevant services is crucial to the smooth execution of collaborative research. This presentation will provide an overview of a model of these services and how, using identity federations and service interoperability, research communities can access, exploit and collaborate around a wide set of services necessary for the smooth execution of their research programme. We show how various models of research projects can be improved and accelerated by using the services in the platform. - Enabling and Improving Research Output : e-Infrastructure and services for African research communities Lagos, Nigeria.
Regioselective synthesis and antibacterial screening of new thiazol-2(3H)-imines linked to arene or chromene units
Creators: name: Abdelfattah, Ahmed M.
name: Sanad, Sherif M. H.
name: Mekky, Ahmed E. M.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
classificationCode: 29999
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Neuroscience
subject: Biotechnology
classificationCode: 39999
subject: Chemical Sciences not elsewhere classified
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
classificationCode: 110309
subject: Infectious Diseases
subject: FOS: Health sciences

description: A one-pot protocol was developed to prepare new thiazol-2(3H)-imines in efficient yields. Therefore, the reaction of the appropriate aromatic amine, phenyl isothiocyanate and chloroacetone (ratio 1:1:1) was mediated using different solvents and bases. The optimized protocol was to conduct the reaction in ethanol at reflux in the presence of 1.2 equivalents of sodium acetate. The reaction produced the regioisomeric (Z)-N-aryl-3-phenylthiazol-2(3H)-imine, as detected by 1D and 2D NMR spectral data. Using a similar protocol, new arene- or chromene-linked thiazol-2(3H)-imines were prepared by the use of the respective α-bromoketones. The new products were screened against six different bacterial strains. In general, chromene-linked thiazol-2(3H)-imines displayed superior antibacterial activity over other products. Thiazol-2(3H)-imines linked to 6-methyl and 6-methoxy-2-oxo-2H-chromene units had the most effective antibacterial activity with MIC/MBC values of 2.0/4.0 and 1.9/3.9 µM, respectively, against Staphylococcus aureus, Streptococcus mutans, and Escherichia coli strains.
Quantum Rotors on the AB$_2$ Chain with Competing Interactions
Creators: name: Tenório, Antônio S. F.
name: Montenegro-Filho, R. R.
name: Coutinho-Filho, M. D.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We present the ground state phase diagram of $q = 1/2$ quantum-rotor chains with competing interactions (frustration) calculated through cluster variational mean field approaches. We consider two interaction patterns, named F$_1$ and F$_2$ models, between the quantum-rotor momentum and position operators, which follow exchange patterns of known one-dimensional spin-1/2 systems with a ferrimagnetic state in their phase diagrams. The spin-1/2 F$_1$ model is known as the diamond chain and is related to the azurite compound, while the spin-1/2 F$_2$ model was recently shown to present a frustration-induced condensation of magnons. We provide a detailed comparison between the quantum-rotor phase diagrams, in single- and multi-site mean-field approaches, and known results for the spin-1/2 models, including exact diagonalization and density matrix renormalization group data for these systems, as well as phase diagrams of the associated classical models.
3D Impacts Modeling of the Magnetic Pulse Welding Process and Comparison to Experimental Data
Creators: name: Cuq-Lelandais, J.-P.
name: Avrillaud, G.
name: Ferreira, S.
name: Mazars, G.
name: Nottebaert, A.
name: Teilla, G.
name: Shribman, V.
Publisher: name: Technische Universität Dortmund
Year: 2016
Subjects: subject: magnetic pulse welding (MPW)
subject: welding windows
subject: dynamic simulations
subject: 620
subject: 670
subject: Impulsschweißen
subject: Simulation
subject: Schweißdraht

description: Magnetic Pulse Welding (MPW) is a solid state (cold) welding process known to present several advantages. When properly designed, such an assembly is stronger than the weakest base material even for multi-material joining. These high quality welds are due to an almost inexistent Heat Affected Zone which is not the case with fusion welding solutions. Another advantage is a welding time that is under a millisecond. In order to define the MPW parameters (mainly geometry, current and frequency), recent developments have made it possible to adapt welding windows from the Explosive Welding (EXW) for use in MPW. Until now, these welding windows have been simulated only in 2D geometries showing how the impact angle and the radial velocities progress in a welding window. The aim of this paper is to present our most recent development, which builds on this analysis to develop a 3D model in order to deal for example with local planar MPW. Simulation results will be presented and then compared to experimental data for a multimaterial join case.
Control charts for the mean based on robust two-sample tests
Creators: name: Abbas, Sermad
name: Fried, Roland
Publisher: name: Technische Universität Dortmund
Year: 2016
Subjects: subject: biosignal analysis
subject: monitoring
subject: two-sample tests
subject: time series
subject: robust control charts
subject: change-point detection
subject: 310
subject: 330
subject: 620

description: We propose and investigate robust control charts for the detection of sudden shifts in sequences of very noisy observations with a naturally slowly varying mean. They sequentially apply local two-sample tests for the location problem. Thus, no previous knowledge about the in-control behaviour is necessary. We identify critical values for the tests to achieve a desired in-control average run length (ARL_0) with extensive simulations. Control charts based on nonparametric tests or a randomization principle provide a satisfactory run length behaviour for different error distributions. They possess a nearly distribution-free ARL_0 and are fast in detecting present signal jumps in a time series. In our simulations and exemplary real-world applications from biosignal analysis, a test based on the two-sample Hodges-Lehmann estimator leads to very promising results regarding distribution independence, robustness and detection speed.
description: Discussion Paper / SFB823;21, 2016
Synthesis, antimicrobial and antioxidant activities of some new pyrazolo[1,5-a]pyrimidine and imidazo[1,2-b]pyrazole derivatives based isoxazole
Creators: name: Alamshany, Zahra M.
name: Tashkandi, Nada Y.
name: Othman, Ismail M. M.
name: Ishak, Esam A.
name: Gad-Elkareem, Mohamed A. M.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
classificationCode: 39999
subject: Chemical Sciences not elsewhere classified
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
classificationCode: 110309
subject: Infectious Diseases
subject: FOS: Health sciences

description: A new set of pyrazolo[1,5-a]pyrimidines 5–8 and imidazo[1,2-b]pyrazoles 9–11 incorporating isoxazole as pharmacologically attractive cores were synthesized starting with aminopyrazole derivative 4. Moreover, the treatment of arylidine derivative 3 with hydroxylamine hydrochloride as nucleophilic reagent afforded the isoxazole derivative 12. All the new target derivatives were assessed in vitro antimicrobial candidates against six strains (three Gram + ve Bacteria and three Gram -ve Bacteria) and two fungi. Target compounds 4, 5, 6, 9 and 10 illustrated potent activity against some of the pathogens compared to the reference drug Ampicillin with minimum inhibitory concentration (MIC) values in some cases less than the reference the other derivatives represented moderate to week and in some cases inactive as a compound 8. Compounds 4, 5, 6 and 10 showed moderate activity against fungi. Finally, antioxidant activities were performed for the most promising targets (except 3a,b and 8) which displayed moderate to very strong antioxidant activities.
État des lieux en pratique pharmaceutique à Haïti – mise en contexte d’un pharmacien – partie V
Creators: name: Bussières, Jean-François
name: Bussières, Virginie
name: Bergeron, Maxime
name: Pinto, Michael
name: Desrosiers, Catherine
name: Hotte, Noémie
name: Roy, Julien
Publisher: name: Unité de recherche en pratique pharmaceutique
Year: 2015
Subjects: Aide humanitaire
Haïti
Pharmacien
Revue de la littérature

description: Haïti est un pays francophone des caraïbes avec qui le Québec entretient des liens privilégiés, compte tenu d’une langue commune, d’une diaspora établie au Québec et des besoins énormes du pays. Dans le cadre du programme intégré de santé Haïti (PISH), un pharmacien du CHU Sainte-Justine a été désigné afin de revoir l’organisation des services et soins pharmaceutiques. Le PISH est un projet sous l’égide de la Croix-Rouge canadienne qui implique notamment le CHU Sainte-Justine. Il s’agit de la cinquième partie de cet état des lieux en pratique pharmaceutique à Haïti, réalisé dans le cadre d’une cinquième mission de 8 jours à Jacmel pour la réorganisation des services et soins pharmaceutiques. La lecture de cet article devrait être précédée des quatre articles précédents [1-4]. Ce cinquième article est aussi une annexe aux rapports de mission d’août 2015 auquel Jean-François Bussières a eu le privilège de contribuer.
Stereoselective total synthesis of Pestalotioprolide C and C7-epi-Pestalotioprolide C
Creators: name: Jami, Pradeep Kumar
name: Battula, Sreenivasa Rao
name: Parimi, Uma Devi
name: Syed, Tasqeeruddin
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
classificationCode: 39999
subject: Chemical Sciences not elsewhere classified
classificationCode: 80699
subject: Information Systems not elsewhere classified
classificationCode: 110309
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: The total synthesis of 14 membered macrolide Pestalotioprolide C and C7-epi- Pestalotioprolide C were accomplished starting from commercially available D-Mannitol by Stereoselective synthetic approach. The key reactions involved are Mitsunobu reaction, Regioselective ring opening of chiral epoxide and ring-closing metathesis reactions (RCM).
title: Validierung der ISGPF-Definition der postoperativen Pankreasfistel – Modifikation von Grad B und C
Creators: name: Hackert, Thilo
name: Hinz, Ulf
name: Pausch, Thomas
name: Fesenbeck, Irina
name: Strobel, Oliver
name: Schneider, Lutz
name: Büchler, Markus Wolfgang
Publisher: name: German Medical Science GMS Publishing House
Year: 2016
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Eine der wichtigsten und potenziell lebensbedrohlichen Komplikationen nach Pankreaseingriffen ist die Entwicklung einer postoperativen Pankreasfistel (POPF), die mit einer Häufigkeit von 3% bis 35%, je nach vorangegangenem Eingriff, auftritt. 2005 wurde von der ISGPF die standardisierte[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 133. Kongress der Deutschen Gesellschaft für Chirurgie
One-pot multicomponent green synthesis of novel series of 4-hydroxy-2-pyridone-fused spiropyrans catalyzed by acetic acid
Creators: name: Kamali, Mahmood
name: Ebrahimi, Asadollah
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Biotechnology
classificationCode: 39999
subject: Chemical Sciences not elsewhere classified
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Hematology
classificationCode: 110309
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: An efficient one-pot multicomponent reaction is reported for synthesizing a novel series 4-hydroxy-2-pyridone-fused spiropyran through the reaction of 4-hydroxy-6-methylpyridine-2-ones alkaloids, malononitrile or ethyl cyanoacetate, and ninhydrin or isatin derivatives. The optimized conditions for this reaction were obtained in ethanol solvent, acetic acid as catalyst, ambient temperature (for ninhydrin) or 70 °C (for isatin), and 8 hr reaction time. Mild and safe conditions, easy work-up and separation, high to excellent yields, and eco-compatibility are the main advantages of this synthesis for affording potentially bio-effective novel products.
From Policy to Prediction: Forecasting COVID-19 Dynamics Under Imperfect Vaccination
Creators: Xiunan Wang
Hao Wang
Pouria Ramazi
Kyeongah Nah
Mark Lewis
Publisher: name: University of Alberta Library
Year: 2022

Understanding the joint impact of vaccination and non-pharmaceutical interventions on COVID-19 development is important for making public health decisions that control the pandemic. Recently, we created a method in forecasting the daily number of confirmed cases of infectious diseases by combining a mechanistic ordinary differential equation (ODE) model for infectious classes and a generalized boosting machine learning model (GBM) for predicting how public health policies and mobility data affect the transmission rate in the ODE model (Wang et al. in Bull Math Biol 84:57, 2022). In this paper, we extend the method to the post-vaccination period, accordingly obtain a retrospective forecast of COVID-19 daily confirmed cases in the US, and identify the relative influence of the policies used as the predictor variables. In particular, our ODE model contains both partially and fully vaccinated compartments and accounts for the breakthrough cases, that is, vaccinated individuals can still get infected. Our results indicate that the inclusion of data on non-pharmaceutical interventions can significantly improve the accuracy of the predictions. With the use of policy data, the model predicts the number of daily infected cases up to 35 days in the future, with an average mean absolute percentage error of 20.15%

, which is further improved to 14.88%

 if combined with human mobility data. Moreover, the most influential predictor variables are the policies of restrictions on gatherings, testing and school closing. The modeling approach used in this work can help policymakers design control measures as variant strains threaten public health in the future.
Inhibition of the endothelin and renin-angiotensin systems : regional haemodynamic effects in rat models of hypertension and acute myocardial infarction
Creators: name: Bunting., Michael W.
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Precise measurement of alpha_K and alpha_T for the 150.8-keV E3 transition in 111Cd: Test of internal-conversion theory
Creators: name: Nica, N.
name: Hardy, J. C.
name: Iacob, V. E.
name: Werke, T. A.
name: Folden, C. M.
name: Pineda, L.
name: Trzhaskovskaya, M. B.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We have measured the K-shell and total internal conversion coefficients, alpha_K and alpha_T, for the 150.8-keV E3 transition in 111Cd to be 1.449(18) and 2.217(26) respectively. The alpha_K result agrees well with Dirac-Fock calculations in which the effect of the K-shell atomic vacancy is accounted for; it extends our precision tests of alpha_K calculations to Z = 48, the lowest Z yet measured. However, the result for alpha_T disagrees by about two standard deviations from the calculated alpha_T value, whether or not the atomic vacancy is included.
description: 7 pages, two figures. arXiv admin note: text overlap with arXiv:1312.3883
title: Einfluss von postoperativer Galleleckage nach Leberteilresektion auf die Leberregeneration
Creators: name: Bednarsch, Jan
name: Blüthner, Elisabeth
name: Malinowski, Maciej
name: Seehofer, Daniel
name: Pratschke, Johann
name: Stockmann, Martin
Publisher: name: German Medical Science GMS Publishing House
Year: 2016
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die postoperative Galleleckage ist die häufigste Komplikation nach Leberteilresektion. Vorklinische Daten zeigen, dass bei präsenten Galleleck eine verzögerte postoperative Leberregeneration vorliegt. Der Einfluss auf den klinischen Verlauf im klinischen Alltag bleibt ist [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 133. Kongress der Deutschen Gesellschaft für Chirurgie
Design, synthesis and biological evaluation of aryl amino derivatives of pyrido [3,2-d]pyrimidines as anticancer agents
Creators: name: Syeda, Arshiya Banu
name: Syeda, Asra Banu
name: Ferazoddin, Mohammad
name: Paul, J. P.
name: Syed, Tasqeeruddin
name: Juluru, Bhasker
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
classificationCode: 39999
subject: Chemical Sciences not elsewhere classified
classificationCode: 80699
subject: Information Systems not elsewhere classified
subject: Cancer

description: A new bunch of substituted aryl amino derivatives structurally modified pyrido[3,2-d]pyrimidines (10a–j) have been synthesized and evaluated for anticancer effects against PC3 (human prostate), A549 (human lung), MCF-7 (human breast) and Colo-205 (human colon) cancer cell lines by utilizing of MTT procedure. Most of the synthesized compounds were showed anticancer activity good to moderate activities with IC50 values range from 0.013 ± 0.0058 µM to 8.22 ± 5.87 µM, whereas, standard 9 etoposide used as standard drug) showed IC50 values from 0.14 ± 0.017 µM to 3.08 ± 0.135 µM, respectively. Among the synthesized compounds, five compounds 10a, 10b, 10c, 10d and 10e demonstrated more potent activity on all cell lines. Mainly, compound 10e displayed higher anticancer activity.
title: Development of a Workflow-oriented Structured Report in Wound Care
Creators: name: Apitz, Martin
name: Kinzel, Konstantin
name: Pahontu, Raluca
name: Heinze, Oliver
name: Bergh, Björn
name: Müller, Beat Peter
name: Kenngott, Hannes Götz
Publisher: name: German Medical Science GMS Publishing House
Year: 2016
Subjects: subject: 610 Medical sciences; Medicine

description: Background: Postoperative wound infections are among the most common postoperative complications in general surgery. With the increase of diabetes mellitus, vascular and cancer diseases in the elderly people, incidence of wound complications and the demand for documentation and visitation might increase.[for full text, please go to the a.m. URL]
description: 133. Kongress der Deutschen Gesellschaft für Chirurgie