cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Synthesis of Non-Steroidal Estrogen Agonists for Hormone Replacement Therapy and Synthesis and Reactivity of 2,3-Substituted 5-Silyl-7-Oxa-Bicyclo[2.2.1]Heptenes and Heptadienes
Creators: name: Chkrebtii, Anna
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: hormone replacement therapy
estrodiol
medicinal chemistry

description: The focus of the research described in this section of the thesis is the synthesis of compounds expected to bind strongly to both the estrogen β and α receptors and act as estrogen agonists. Based on earlier results in our group and docking studies we prepared a series of A-CD analogs, compounds 1, in which the usual 13-methyl group was replaced by an ethyl group. Docking studies also indicated that substituents at C8 could lead to enhancement of binding to the estrogen receptor. With this in mind two such derivatives, compounds 2 were prepared. A major concern in the use of estradiol in hormone replacement therapy is its potential metabolism of dangerous ortho-quinones. The 1,2-naphthalenediol derivatives 3 avoid this possibility. They were predicted to be potent binders to the estrogen receptors with the naphthalene diol portion serving as rings A and B and the hydroxyl group taking the place of the 17-OH group of estradiol. The preparation of several derivatives of 2 is reported. The estrogen receptor binding [ERB] relative to estradiol as standard has been determined at the University of Illinois for a number of the compounds prepared in this thesis. Unfortunately, the results were not as encouraging as expected. Importantly, all of the 13-ethyl derivatives tested showed lower binding affinity compared to the 13-methyl analogs. Similarly, the derivatives with substituents at C8 do not show higher activity than those having only hydrogens at C8. Finally, the situation with the naphthalene derivatives is, at this stage, still not completely resolved. The binding for the compounds thus tested is quite low, but it must be admitted that the structures thus far synthesized have a much lower LogP than estradiol, a factor known to greatly decrease the binding constants to the estrogen receptors.
Climate risk assessments at the municipal level
Creators: name: Porst, Luise
name: Voß, Maike
name: Schauser, Inke
name: Kahlenborn, Walter
Publisher: name: Umweltbundesamt
Year: 2022
Subjects: subject: Klimaänderung
subject: Anpassung an den Klimawandel
subject: Klimarisiko
subject: Deutsche Anpassungsstrategie an den Klimawandel
subject: Anpassung
subject: climate change
subject: climate risk
subject: Adaptation
subject: DAS
subject: municipalities
subject: Climate Risk Assessments
subject: guide
subject: Climate | Energy

description: In view of the ever-increasing progress of climate change, the importance of climate risk assessments is growing. They play a major role at the municipal level in particular (cities, distriscts, municipalities), because it is here that precautionary action must take place in the face of the dangers of he climate crisis. The recommendations in this papier provide support for he preparation and implementation of climate risk assessments at the municipal level. They summarise the international standard: Adaptation to climate change-Guidelines on vulnerability, impacts and risk assessment (ISO 14091:2021-07) and supplement this general guideline with specific recommendations for municipalities. Quelle: www.umweltbundesamt.de
description: In view of the ever-increasing progress of climate change, the importance of climate risk assessments is growing. They play a major role at the municipal level in particular (cities, distriscts, municipalities), because it is here that precautionary action must take place in the face of the dangers of the climate crisis. The recommendations in this papier provide support for the preparation and implementation of climate risk assessments at the municipal level. They summarise the international standard: ⁠Adaptation⁠ to climate change-Guidelines on vulnerability, impacts and risk assessment (ISO 14091:2021-07) and supplement this general guideline with specific recommendations for municipalities.
Group-based distributed computing: Programming and distributed platform model.
Creators: name: Farooqui, Kazi.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Computer Science.

description: Much research has been done in the past in the area of group communication. However most of this research exists in the low-level support for group communication, such as different types of ordered and reliable multicast protocols, membership management protocols, virtual synchrony, replication techniques, etc. Most of this research provides only low-level pieces of the complete puzzle. The big picture involves a vision of group-based distributed computing . This vision calls for a shift of focus from low-level issues of group communication to the high-level issues of an overall distributed environment capable of supporting group-based distributed computing applications . This thesis is focussed on the dual models of the distributed environment---the distributed programming model and the distributed platform model, required for the support of group-based distributed computing applications. The thesis presents the software architecture of an agent-based and policy-driven group support platform in an implementation independent manner. This is an extensible, configurable and programmable software architecture which permits the separation of group coordination aspects from the application issues. The goal is to enhance the level of middleware support provided by the current generation of distributed platforms such as CORBA. The thesis identifies a set of "middleware-level" group support services (GSSs), such as message distribution service, collation service, synchronisation service, filtering service, etc. commonly required by group-based applications and the corresponding group support agents (GSAs). The thesis presents a framework for the organisation of these group support agents. This framework is called the group support machine (GSM). This thesis is based upon the architectural principles underlying object-based distributed systems architectures such as RM-ODP, ANSA, ROSA, OMA, etc., and is scoped within the ODP computational and engineering models. (Abstract shortened by UMI.)
Effects of sphingosine-1-phosphate on cell viability, differentiation, and gene expression of adipocytes
Creators: name: Wu, Xiyuan
name: Sakharkar, Meena Kishore
name: Wabitsch, Martin
name: Yang, Jian
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: sphingosine-1-phosphate
subject: preadipocyte
subject: cell viability
subject: adipocyte differentiation
subject: transcriptomics
subject: DDC 610 / Medicine & health
subject: Sphingosine
subject: Sphingolipids
subject: Adipocytes
subject: Gene expression
subject: Gene expression profiling
subject: Cell survival
subject: Sphingosin
subject: Fettzelle
subject: Genexpression

description: Sphingosine-1-phosphate (S1P) is a highly potent sphingolipid metabolite, which controls numerous physiological and pathological process via its extracellular and intracellular functions. The breast is mainly composed of epithelial cells (mammary gland) and adipocytes (stroma). Adipocytes play an important role in regulating the normal functions of the breast. Compared to the vast amount studies on breast epithelial cells, the functions of S1P in breast adipocytes are much less known. Thus, in the current study, we used human preadipocyte cell lines SGBS and mouse preadipocyte cell line 3T3-L1 as in vitro models to evaluate the effects of S1P on cell viability, differentiation, and gene expression in adipocytes. Our results showed that S1P increased cell viability in SGBS and 3T3-L1 preadipocytes but moderately reduced cell viability in differentiated SGBS and 3T3-L1 adipocytes. S1P was also shown to inhibit adipogenic differentiation of SGBS and 3T3-L1 at concentration higher than 1000 nM. Transcriptome analyses showed that S1P was more influential on gene expression in differentiated adipocytes. Furthermore, our network analysis in mature adipocytes showed that the upregulated DEGs (differentially expressed genes) were related to regulation of lipolysis, PPAR (peroxisome proliferator-activated receptor) signaling, alcoholism, and toll-like receptor signaling, whereas the downregulated DEGs were overrepresented in cytokine-cytokine receptor interaction, focal adhesion, starch and sucrose metabolism, and nuclear receptors pathways. Together previous studies on the functions of S1P in breast epithelial cells, the current study implicated that S1P may play a critical role in modulating the bidirectional regulation of adipocyte-extracellular matrix-epithelial cell axis and maintaining the normal physiological functions of the breast.
Ion implantation induced interdiffusion in quantum wells for optoelectronic device integration
Creators: name: Fu, L.
name: Tan, H. H.
name: Cohen, M. I.
name: Jagadish, C.
name: Dao, Lap
name: Gal, M.
name: Li, N.
name: Liu, X.
name: Lu, W.
name: Shen, S. C.
Publisher: name: Swinburne
Year: 2024

description: Ion implantation induced intermixing of GaAs/AlGaAs and InGaAs/AGaAs quantum wells was studied using low temperature photoluminescence. Large energy shifts were observed with proton implantation and subsequent rapid thermal annealing. Energy shifts were found to be linear as a function of dose for doses as high as ∼5×1016 cm-2. Proton implantation and subsequent rapid thermal annealing was used to tune the emission wavelength of InGaAs quantum well lasers as well as detection wavelength of GaAs/AlGaAs quantum well infrared photodetectors (QWIPs). Emission wavelength of lasers showed blue shift whereas detection wavelength of QWIPs was red shifted with intermixing.
(In)Formative Assessment Techniques in Blended and E-Learning Environments
Creators: name: Caraivan, Maria-Luiza
Publisher: name: Editura Universitara
Year: 2012
Subjects: subject: 0 Social sciences
subject: 37 Education
subject: 371 Instructional design
subject: 004:37 Elearning

description: The paper analyses the role of formative, constructive assessment techniques in higher education taking into account the teaching-learning process in the context of the blended and elearning environments.
'A limit to this right of overlooking'
Creators: name: Given, Jock
Publisher: name: Swinburne
Year: 2024

description: Australians are likely to get a statutory right of privacy. Though it needs careful crafting, it's high time, writes Jock Given. Review of the books 'For your information: Australian privacy law and practice', published by the Australian Law Reform Commission, Sydney, 2008; 'Blown to bits: your life, liberty and happiness after the digital explosion' by Hal Abelson, Ken Ledeen and Harry Lewis, published by Addison-Wesley, Upper Saddle River, 2008; 'The spy in the coffee machine: the end of privacy as we know it' by Kieron O’Hara and Nigel Shadbolt, published by Oneworld, Oxford, 2008; and 'Privacy: a manifesto' by Wolfgang Sofsky, published by Princeton University Press, Princeton, 2008.
Uni Ulm intern - das Ulmer Universitätsmagazin, Nr. 270 (34. Jg.), September 2004
Creators: name: (:Unkn) Unknown
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: Uni Ulm intern
subject: Universities; Germany; Ulm
subject: Ulm / Universität

description: N/A
Transnational education zones: Towards an urban political economy of ‘education cities’
Creators: name: Kleibert, Jana M.
name: Bobée, Alice
name: Rottleb, Tim
name: Schulze, Marc Philipp
Publisher: name: Humboldt-Universität zu Berlin
Year: 2020
Subjects: subject: agglomeration
subject: economic processes
subject: education
subject: education cities
subject: globalisation
subject: international branch campus
subject: place branding
subject: urbanisation
subject: 300 Sozialwissenschaften
subject: 330 Wirtschaft

description: Prevalent notions of ‘education cities’ and ‘education hubs’ are vaguely defined, operate at blurry scales and tend to reproduce promotional language. The article contributes to theorising the geographies and spaces of globalising higher education by developing the concept of transnational education zones. Through an urban political economy lens, we review the relations between universities and cities, consider universities’ role in the political economy and understand universities as transnational urban actors. We exhaustively map the phenomenon of transnational education zones and empirically analyse cases from four cities (Doha, Dubai, Iskandar and Flic en Flac) with respect to their embeddedness in state-led projects for the ‘knowledge economy’, their vision for transnational subject formation and their character as urban zones of exception. The conclusion develops a research agenda for further critical geographic inquiries into the (re)making of cities through the development of transnational spaces of higher education that explores the relations between globalising higher education and material and discursive transformations at the urban scale.
The Dynamics of the Teacher s Roles in an ICT Language Class
Creators: name: Catelly, Yolanda-Mirela
Publisher: name: Editura Universitara
Year: 2012
Subjects: subject: 0 Social sciences
subject: 37 Education
subject: 371 Instructional design
subject: 004:37 Elearning

description: The paper is meant as a radiograph of the roles a teacher should assume in response to the knowledge society demands from education. The issue that is investigated is whether teachers can contribute to better ensuring the instruction process efficiency by adopting an attitude of permanent professional reflection and open-mindedness, mainly focused on identifying the pedagogic rationale underlying their teaching options.
Testing population-based performance measures identifies gaps in juvenile idiopathic arthritis (JIA) care
Creators: name: Barber, Claire E
name: Lix, Lisa M
name: Lacaille, Diane
name: Marshall, Deborah A
name: Kroeker, Kristine
name: Benseler, Susanne
name: Twilt, Marinka
name: Schmeling, Heinrike
name: Barnabe, Cheryl
name: Hazlewood, Glen S
name: Bykerk, Vivian
name: Homik, Joanne
name: Thorne, J. C
name: Burt, Jennifer
name: Mosher, Dianne
name: Katz, Steven
name: Shiff, Natalie J
Publisher: name: BioMed Central
Year: 2019

description: Background: The study evaluates Performance Measures (PMs) for Juvenile Idiopathic Arthritis (JIA): The percentage of patients with new onset JIA with at least one visit to a pediatric rheumatologist in the first year of diagnosis (PM1); and the percentage of patients with JIA under rheumatology care seen in follow-up at least once per year (PM2). Methods: Validated JIA case ascertainment algorithms were used to identify cases from provincial health administrative databases in Manitoba, Canada in patients < 16 years between 01/04/2005 and 31/03/2015. PM1: Using a 3-year washout period, the percentage of incident JIA patients with ≥1 visit to a pediatric rheumatologist in the first year was calculated. For each fiscal year, the proportion of patients expected to be seen in follow-up who had a visit were calculated (PM2). The proportion of patients with gaps in care of > 12 and > 14 months between consecutive visits were also calculated. Results: One hundred ninety-four incident JIA cases were diagnosed between 01/04/2008 and 03/31/2015. The median age at diagnosis was 9.1 years and 71% were female. PM1: Across the years, 51–81% of JIA cases saw a pediatric rheumatologist within 1 year. PM2: Between 58 and 78% of patients were seen in yearly follow-up. Gaps > 12, and > 14, months were observed once during follow-up in 52, and 34%, of cases, and ≥ twice in 11, and 5%, respectively. Conclusions: Suboptimal access to pediatric rheumatologist care was observed which could lead to diagnostic and treatment delays and lack of consistent follow-up, potentially negatively impacting patient outcomes.
Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice
Creators: name: Peter, Sasa
name: Ten Brinke, Michiel M.
name: Stedehouder, Jeffrey
name: Reinelt, Claudia M.
name: Wu, Bin
name: Zhou, Haibo
name: Zhou, Kuikui
name: Boele, Henk-Jan
name: Kushner, Steven A.
name: Lee, Min Goo
name: Schmeisser, Michael J.
name: Böckers, Tobias M.
name: Schonewille, Martijn
name: Hoebeek, Freek E.
name: De Zeeuw, Chris I.
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: Plasticity
subject: Expression
subject: Pathophysiology
subject: Identification
subject: Consolidation
subject: DDC 150 / Psychology
subject: Autism in children
subject: Synaptic transmission
subject: Autism spectrum disorder; Genetics
subject: Genes
subject: Mutation
subject: Autismus
subject: Synaptische neuronale Plastizität
subject: Gen

description: Loss-of-function mutations in the gene encoding the postsynaptic scaffolding protein SHANK2 are a highly penetrant cause of autism spectrum disorders (ASD) involving cerebellum-related motor problems. Recent studies have implicated cerebellar pathology in the aetiology of ASD. Here we evaluate the possibility that cerebellar Purkinje cells (PCs) represent a critical locus of ASD-like pathophysiology in mice lacking Shank2. Absence of Shank2 impairs both PC intrinsic plasticity and induction of long-term potentiation at the parallel fibre to PC synapse. Moreover, inhibitory input onto PCs is significantly enhanced, most prominently in the posterior lobe where simple spike (SS) regularity is most affected. Using PC-specific Shank2 knockouts, we replicate alterations of SS regularity in vivo and establish cerebellar dependence of ASD-like behavioural phenotypes in motor learning and social interaction. These data highlight the importance of Shank2 for PC function, and support a model by which cerebellar pathology is prominent in certain forms of ASD.
Supplementary document for Enhanced Radiative and Thermal Properties from Surface Encapsulation of InAs Nanowires - 5055633.pdf
Creators: name: Li, Xinxin
name: Walhof, Alexander
name: Dai, Weitao
name: Arslan, Ilke
name: Liu, Yuzi
name: Toor, Fatima
name: Prineas, John
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary document
An empirical investigation of group treatment for a clinical population of adult female incest survivors.
Creators: name: Saxe, Brenda.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Women's Studies.

description: Because of the high prevalence of childhood incest in therapy-seeking populations of women, it is important to determine the treatment approaches that are most effective in resolving the negative consequences of this traumatic event. Although there is a general consensus in the clinical literature that a group treatment approach offers unique therapeutic benefits for this population that are not available in individual therapy, there is little empirical evidence to support this contention. The purpose of the present study was to empirically assess the effectiveness of a group treatment program on intrapersonal symptomatology and interpersonal difficulties in a clinical population of women with a history of incest. Subjects for the study were drawn from participants in a group treatment program conducted by a community-based, mental health agency and developed specifically for women with a history of incest. Thirty-two women who participated in the 20-week group treatment program were compared to thirty-one women who were wait-listed for the program for a similar period of time on measures of intrapersonal symptomatology and interpersonal difficulties. In addition, the effects of the group treatment program across time were examined by assessing intrapersonal symptomatology and interpersonal difficulties in group participants six months following completion of the group treatment program. Results indicate that a time-limited group which focuses on the original trauma is effective in reducing intrapersonal symptomatology for women with a history of incest and that this improvement is stable over time. Although the women who received group treatment felt more support from friends following their experience in the group and appeared to see themselves in a more positive light in their relations with other women over time, interpersonal difficulties, in general, did not show as much improvement as intrapersonal symptomatology. Clinical implications of these findings as well as suggestions for future research are discussed.
Supervision in work experience for learning programs
Creators: name: Hays, Jay
name: Clements, Mike
Publisher: name: Swinburne
Year: 2024

description: Few would dispute that supervision is an important element in work-study programs. The attention given to duty of care, administration, work performance, and learning depend on the role taken: industry (work site) supervisor or academic supervisor or mentor. As a general rule, academics stress the learning aspects of the job and its relationship to the area of study, while employers are more concerned with students' performance in the job and their potential as full-time employees once they have graduated. The centrepiece of this paper is the comparison of an ideal, theoretical model of supervision distilled from the literature with an actual model developed from reports of academic and industry supervisors. Preliminary findings from an on-going study suggest that relevant student learning at the work site happens, but randomly and coincidentally. There appears to be little direct correspondence between what academics hope and expect students learn (within their disciplines) and what is actually learned. Academic supervisors and mentors do little to help students make the connection between work and study. Their work site supervisors even less. More can and should be done to facilitate student learning if these programs are to ensure the best possible overall experience and learning of students on the job. The paper identifies opportunities to enhance the experience and learning before, during, and after the work placement. The major conclusion is that supervision is crucial to a positive work-study experience and effective learning for students. A model for inducting, developing, and supporting industry and academic supervisors is provided.
Variations of A* for searching in abstraction hierarchies.
Creators: name: Perez, Maria Beatriz.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Information Science.

description: The aim of this work is to show the usefulness of abstraction in heuristic search. We use the abstract spaces created by applying abstraction techniques to the original problem. These abstract spaces are then used to generate all the heuristic information necessary in order to find an optimal or near optimal solution to the original problem. One of our objectives is to preserve optimal paths while speeding up search. We have developed new approaches to speed-up A$\sp{*}$ in an abstraction hierarchy: abstract solutions, minimum edge weight, P-G to generated heuristics from the length of the solution path for those nodes visited during search, and reuse of heuristic information generated from previous searches. We also consider an approach which postpones the calculation of heuristics obtained by searching in the abstract space. This approach is referred to as Lazy Evaluation. Another of our objectives is to achieve more speed in search sacrificing optimality. For this we introduce a technique called Selective Method. Our last objective is to identify which abstraction method is the best for the search. We build abstraction hierarchies with different abstraction methods and we evaluate them using different search techniques: Classical Refinement (CR), Optimal Refinement (OR), and Alternating Opportunism (AO), and our variations of A$\sp{*}$.
Physical, chemical and geochemical factors influencing mercury accumulation in freshwater fish and humans in Ontario, Canada.
Creators: name: Richardson, G. Mark.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Biology, Ecology.

description: An empirical approach was taken to examine and test a variety of hypotheses that had been presented or postulated in the literature concerning mercury biogeochemistry in lakes. These hypotheses included: (1) mercury contamination in fish increases with increasing sulphate deposition; (2) mercury exposure in persons eating fish increases with increasing sulphate deposition; (3) mercury contamination in fish is unrelated to natural (non-anthropogenic) Hg sources. These hypotheses were all shown to be false for Ontario lakes, predominantly of the Canadian Shield. Also examined was the spatial association of lake water chemistry with sulphate deposition across Ontario. It was determined that morphometric characteristics of the lakes, as well as watershed buffering capacity, together explained more of the spatial variation in lake water chemistry than did patterns of sulphate deposition across the province. Once these confounding influences were removed, the water chemistry variables most closely reflecting patterns of sulphate deposition were dissolved organic carbon (DOC) and sulphate ion concentration ( (SO$\sb4\sp{2-}$)), not pH or alkalinity. Aluminum ion concentration ( (Al$\sp-$)), which is postulated to increase in lakes as a result of acidic deposition, had no discernible relationship to sulphate deposition. Based on the results of empirical analyses, including path analysis (causal modelling), a complex hypothesis explaining the interrelationships of precipitation, water chemistry, geochemistry, and fish mercury contamination was postulated. Of particular note concerning this model were the following: (1) fish mercury and human mercury exposure decrease as sulphate deposition increases; (2) DOC, not pH or alkalinity, is the water chemistry variable most significantly related to sulphate deposition; (3) DOC, not pH, is the water chemistry variable most significantly associated with fish mercury contamination; (4) causal modelling provided empirical evidence supporting the simultaneous influence of 3 different mechanisms postulated in the literature to control or influence mercury accumulation in freshwater fish.
Les relations internationales et l'activisme des vedettes de la musique: Une théorisation à partir d'études de cas
Creators: name: Côté, Thierry
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Music.
subject: Political Science, International Law and Relations.

description: Alors que les interventions de vedettes de la musique dans la politique ne sont pas en soi un phénomène nouveau, certaines interventions plus récentes se tournent vers des enjeux internationaux ou transnationaux (Bob Geldof, Sting, Bono). À partir d'un cadre conceptuel fondé sur la force politique de la musique populaire et des artistes, les effets de la mondialisation, le rôle et les méthodes des organisations de mouvements sociaux transnationaux et le concept de réseau transnational de plaidoyers, nous avons analysé un ensemble d'exemples, ainsi que l'intervention de Bono dans la campagne de Jubilee 2000, afin de bâtir une typologie des formes d'interventions et vérifier l'hypothèse selon laquelle les vedettes ont un impact (particulièrement sur les politiques et pratiques) lorsqu'elles font preuve d'un engagement prolongé, visent des objectifs précis et acceptent de mettre leurs ressources, leur art et leur célébrité mondiale au service d'un enjeu et d'un réseau transnational de plaidoyers.
An energy- and cost-aware computation offloading method for workflow applications in mobile edge computing
Creators: name: Peng, Kai
name: Zhu, Maosheng
name: Zhang, Yiwen
name: Liu, Lingxia
name: Zhang, Jie
name: Leung, Victor Chung Ming, 1955-
name: Zheng, Lixin
Publisher: name: Springer International Publishing
Year: 2019

description: Mobile edge computing is becoming a promising computing architecture to overcome the resource limitation of mobile devices and bandwidth bottleneck of the core networks in mobile cloud computing. Although offloading applications to the cloud can extend the performance for the mobile devices, it may also lead to greater processing latency. Usually, the mobile users have to pay for the cloudlet resource or cloud resource they used. In this paper, we bring a thorough study on the energy consumption, time consumption, and cost of using the resource of cloudlet and cloud for workflow applications in mobile edge computing. Based on theoretical analysis, a multi-objective optimization model is established. In addition, a corresponding multi-objective computation offloading method based on non-dominated sorting genetic algorithm II is proposed to find the optimal offloading strategy for all the workflow applications. Finally, extensive experimental evaluations are performed to show that our proposed method is effective and energy- and cost-aware for workflow applications in MEC.
Gene expression in synovial fibroblasts from rheumatoid arthritis and osteoarthritis patients Novel expression of IL-19 and IL-22 by fibroblasts
Creators: name: MacDonald, Daniel Francis
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Biology, Microbiology.

description: Our objective was to study gene expression related to cytokines and cytokine receptors in FLS. We were looking for any previously unidentified cytokines and receptors that may play a role in the pathogenesis of RA. Using a microarray-based approach to identify any potential expressed cytokine genes we found that two pro-inflammatory cytokines belonging to the IL-10 family of cytokines, IL-19 and IL-22, are constitutively expressed in cultured FLS, and this expression was independent of length of culture. The other work in this thesis focused on identifying potential cytokine receptors expressed in FLS and other cells. From these studies, it was identified that FLS do not express membrane bound receptors for IL-19 or other IL-10 family members, but they are capable of expressing IL-22BP, a non membrane bound soluble form of the IL-22 receptor. This is the first indication that fibroblasts are capable of transcribing this gene. The work presented in this thesis has addressed gene expression in FLS and the findings may prove to be important in understanding maintenance of inflammation in RA. The finding that FLS can transcribe mRNA for IL-19 and IL-22, may indicate that these cells are important sources of these pro-inflammatory cytokines in vivo. The receptor studies may also prove to be useful in expanding the knowledge of receptor expression in FLS. (Abstract shortened by UMI.)
Wie schlimm sind Weichmacher, PFAs & Co?
Creators: name: (:Unkn) Unknown
Publisher: name: ZDF Terra Xplore
Year: 2023

description: Vergiften wir uns, ohne, dass wir davon etwas mitbekommen? Wusstet ihr, dass in eurer Kleidung, in eurer Kosmetik, in euren Nahrungsmitteln Schadstoffe enthalten sein können? Weichmacher, Pestizide, PFAS - so genannte Umweltgifte stecken in ziemlich vielen Dingen unseres Alltags. Doch sind sie wirklich so gefährlich, dass wir Angst vor ihnen haben sollten? Wie viel davon nehmen wir täglich auf? Und können wir uns vor ihnen schützen? Das möchte Thora in dieser Folge #TerraXplore herausfinden und trifft dafür Tina, die versucht, Umweltgifte in ihrem Alltag größtenteils zu vermeiden - z. B., indem sie weitestgehend plastikfrei lebt. Funktioniert das? Worauf muss man achten? Außerdem macht Thora den Test: Wie vergiftet ist ihr Körper - und mit welchen Schadstoffen? Dafür spricht sie mit der Toxikologin Dr. Marike Kolossa und möchte wissen: In welchen Produkten stecken besonders viele Weichmacher und Co. drin? Und könnten Detox-Produkte wie Tees uns dabei helfen, unsere Körper wieder zu entgiften? Quelle: youtube.com
Scalability for supporting the growth of hospitals: application at Thailand hospitals
Creators: name: Sakphisal, Adisak
name: Higgins, Peter
Publisher: name: Swinburne
Year: 2024

description: Public hospitals in Thailand have been forced to serve dramatically increased numbers of patients since the National Health Security Act 2002 gave access to free medical treatment. The challenge to hospitals is to plan for increasing resources and facilities of service processes to serve more patients. A model for analysing the scalability of factors necessary to the growth in hospital size has been developed. In its development, we focused on one part of the hospital, the outpatient department (OPD). The model is an outcome of three-stage study of OPDs. In the first stage, the OPD at a single hospital was investigated for the identification of key factors associated with patient flow. The second stage, the investigation expanded to seven hospitals so to find patterns in performance based on principles of Lean Systems. In the final stage, a descriptive model of 'scalability' was created. The objective of the model is to guide hospitals in planning their growth in size.
Supplementary document for Effect of Alloying on the Dynamics of Coherent Acoustic Phonons in Bismuth Double Perovskite Single Crystals - 5057822.pdf
Creators: name: Lin, Xihong
name: Wu, Bo
name: Ning, Weihua
name: Feng, Minjun
name: Xu, Qiang
name: Gao, Feng
name: Sum, Tze Chien
name: Zhou, Guofu
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement 1
Evaluation of the application of different diffusion models for the methanation of CO/CO2 mixtures
Creators: name: Schumacher, Jannik
name: Meyer, Dominik
name: Friedland, Jens
name: Güttel, Robert
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: CO/CO2 mixtures
subject: Simulation study
subject: Multicomponent diffusion
subject: Porous catalyst pellet
subject: DDC 540 / Chemistry & allied sciences
subject: Methanation
subject: Methanisierung

description: CO/CO2-Methanation can contribute to the storage of intermittently produced renewable energy. In order to be able to design this heterogenous catalytic process well with models, a solid diffusion model is necessary. Thus, the effects of diffusion model selection are simulated in this context under steady-state and unsteady-state conditions. Therefore, the dusty gas and the Wilke-Bosanquet model are compared with the binary friction model. The operation conditions are varied over a wide range to achieve general validity of conclusions. It is shown that all diffusion models lead to similar results for high Knudsen numbers and for steady-state conditions. Under unsteady-state conditions in porous catalyst pellets with low Knudsen numbers, however, the results differ and thus the binary friction model is recommended. Although the simulations were carried out with methanation as an example reaction, the results are transferable to comparable heterogeneously catalyzed gas phase reactions.
Les Nomades globaux : langue d'instruction et société; étude sur certains Nomades globaux scolarisés dans des établissements francophones lorsqu’ils vivaient à l’étranger
Creators: name: Carruthers, Clive Alexander
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Third Culture Kid
Global Nomad
Habitus
Enskilment
Ingold
Bourdieu

description: Depuis les années 1950, des chercheurs comme Useem, Pollock, Van Reken et d’autres se sont interrogés sur le sujet des enfants qui ont grandi dans plusieurs pays. Cependant, la grande majorité de ce corpus vise les enfants ayant été scolarisés dans des établissements anglophones même s’il existe de nombreux établissements francophones hors la France. Ce projet vise cette population. Nous nous sommes demandés s’ils faisaient partie d’une double minorité, premièrement la minorité de Nomades Globaux (NG) mais dans cette population s’ils faisant partie d’une minorité francophone de NG. Pour ce faire, nous avons conduit des entrevues semi-structurées avec 12 participants en utilisant un cadre théorique construit autour de l’habitus de Pierre Bourdieu. Bien que nous ne puissions tirer de conclusions générales, il semble que ces NG ne se sentent pas comme faisant partie d’une double minorité.
The Role of Biodegradable Engineered Nanofiber Scaffolds Seeded with Hair Follicle Stem Cells for Tissue Engineering
Creators: name: Hejazian, Leila Beigom
name: Esmaeilzadeh, Banafsheh
name: Ghoroghi, Fatima Moghanni
name: Moradi, Fatemeh
name: Hejazian3, Marzieh Beigom
name: Aslani, Anahita
name: Bakhtiari, Mehrdad
name: Soleimani, Masoud
name: Maliheh Nobakht
Publisher: name: the Pasteur Institute of Iran
Year: 1996
Subjects: subject: Basic Sciences

description: Iranian Biomedical Journal (IBJ); ISSN 1028-852X
The discovery of an eccentric millisecond pulsar in the galactic plane
Creators: name: Champion, David J.
name: Ransom, Scott M.
name: Lazarus, Patrick
name: Camilo, Fernando
name: Kaspi, Victoria M.
name: Nice, David J.
name: Freire, Paulo C. C.
name: Cordes, James M.
name: Hessels, Jason W.
name: Bassa, Cees
name: Lorimer, Duncan R.
name: Stairs, Ingrid H.
name: Van Leeuwen, Joeri
name: Arzoumnian, Zaven
name: Backer, Donald C.
name: Bhat, N. D. R.
name: Chatterjee, Shami
name: Crawford, Fronefield
name: Deneva, Julia S.
name: Faucher-Giguere, Claude Andre
name: Gaensler, Bryan M.
name: Han, Jinlin Lin
name: Jenet, Fredrick A.
name: Kasian, Laura
name: Kondratiev, Vlad I.
name: Kramer, Michael
name: Lazio, Joseph
name: McLaughlin, Maura A.
name: Stappers, Benjamin W.
name: Venkataraman, Arun
name: Vlemmings, Wouter
Publisher: name: Swinburne
Year: 2024

description: The evolution of binary systems is governed by their orbital properties and the stellar density of the local environment. Studies of neutron stars in binary star systems offer unique insights into both these issues. In an Arecibo survey of the Galactic disk, we have found PSR J1903+0327, a radio emitting neutron star (a 'pulsar') with a 2.15 ms rotation period, in a 95-day orbit around a massive companion. Observations in the infra-red suggests that the companion may be a main-sequence star. Theories requiring an origin in the Galactic disk cannot account for the extraordinarily high orbital eccentricity observed (0.44) or a main-sequence companion of a pulsar that has spin properties suggesting a prolonged accretion history. The most likely formation mechanism is an exchange interaction in a globular star cluster. This requires that the binary was either ejected from its parent globular cluster as a result of a three-body interaction, or that that cluster was disrupted by repeated passages through the disk of the Milky Way.
Processing Compound Verbs in Persian
Creators: name: Shabani-Jadidi, Pouneh
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: masked priming
morphology
complex predicates
compound verbs
compound words
priming
processing

description: This study investigates how Persian compound verbs are processed in the mental lexicon, through which we can infer how they are stored, organized, and accessed. The study focuses on investigating Persian compound verbs in light of psycholinguistic theories on polymorphemic word processing as well as linguistic theories of complex predicates. The psycholinguistic section details three experiments addressing the following three research questions: (1) whether compound verb constituents show significant priming in the masked-priming paradigm; (2) whether priming effects are constrained by semantic transparency; and (3) whether priming effects are due to morphological relatedness. This study revealed several findings: (1) compound verbs in Persian are decomposed into their constituents at early stages of processing, (2) at early stages of processing, decomposition is based on purely orthographic similarity, (3) although both transparent and opaque compound constituents were facilitated while processing, transparency had an impact on processing in the early stages of processing. Finally, the findings seem to support a parallel input effect or competing alternative effect for the verbal constituent of the transparent compound verb, as reflected in the slower facilitation for the verbal constituent compared to the nominal constituent. In theoretical studies on Persian complex predicates, the compound verb formation can be either lexical or syntactic. The overall evidence reflected in the linguistic data for Persian complex predicates presented in this dissertation as well as the results of the experimental studies carried out in this research seem to point towards lexical compounding in Persian compound verb formation. The evidence comes from (1) the nominalization of the compound, i.e. the possibility of using the compound verb as a noun; (2) the atelicity feature, i.e. the possibility of using the compound verb after the progressive expression dar haale ‘in the process of’, which indicates an incomplete action; and (3) the nonreferentiality of the nominal constituent in the compound verb, i.e. the nominal constituent cannot be followed by a pronoun that refers to it. On the other hand, the results of the experimental studies reported in this dissertation seem to support a lexical approach to compound verbs in Persian. The technique used in these experimental studies was masked priming paradigm, which investigates the prelexical and lexical processing. The results reveal constituent priming effects under masked priming technique. This indicates that Persian compound verb constituents are accessed at the prelexical stage of processing. Syntactic calculations are said to be done at later stages of processing. Therefore, the early processing of compound verb constituents leads us to the argument for the lexicality of Persian compound verbs.
Comparative Study of Immunological and Structural Properties of Two Recombinant Vaccine-Candidates against Botulinum Neurotoxin Type E
Creators: name: Mosayeb Rostamian
name: Mousavy, Seyed Jafar
name: Ebrahimi, Firouz
name: Seyyed Abolghasem Ghadami
name: Sheibani, Nader
name: Minaei, Mohammad Ebrahim
name: Torabi, Mohammad Ali Arefpour
Publisher: name: the Pasteur Institute of Iran
Year: 1996
Subjects: subject: Basic Sciences

description: Iranian Biomedical Journal (IBJ); ISSN 1028-852X
Preparation of enantiomerically enriched heterocycles via dynamic kinetic resolution: Exploration of new paths to benzocyclobutenones and benzocyclobutenols.
Creators: name: LeBlanc, Richard.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Chemistry, Organic.

description: The preparation of enantiomerically enriched bi- and tricyclic heterocycles via a dynamic kinetic resolution protocol is discussed. This methodology was applied to the reaction of o-bromo-alpha-iodo alkyl [R]-pantolactone esters with a number of bifunctional nucleophiles such as, 1,2-phenylenediamine, which resulted in the formation of bicyclic piperazines. Several other nucleophiles such as 2-aminophenols, also formed the expected heterocycles, but aliphatic 1,2-diamines tended to give elimination rather than displacement products, with the above dihalo esters. The preparation of these heterocycles in a simple three step sequence, starting from commercially available o-bromo alkyl acids is detailed. Attempts were made to prepare benzocyclobutenones and benzocyclobutenols via halogen-metal exchange and subsequent cyclization in o-halobenzyl cyanide. Finally, the reaction of amide, ester and ketone enolates with a benzyne species generated via reaction of halobenzenes with lithium 2,2,6,6-tetramethylpiperidide at room temperature or below is also discussed. The reaction of amide and ester enolates with benzynes has not been previously discussed in the literature. Surprisingly, reaction of ester or amide enolates with benzyne in the presence of excess iodobenzene afforded substituted iodobenzenes as the major reaction product. These products were obtained by reaction of the enolates with benzynes followed by transfer of iodine from iodobenzene. The results represent the first example in which iodobenzene acts as a positive source of halogen.
Pulp and Paper Mill Fly Ash: A Review
Creators: name: Cherian, Chinchu
name: Siddiqua, Sumi
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: The continual growth of pulp and paper industry has led to the generation of tremendous volumes of fly ash as byproducts of biomass combustion processes. Commonly, a major part of it is landfilled; however, updated environmental regulations have tended to restrict the landfilling of fly ash due to rising disposal costs and the scarcity of suitable land. The pulp and paper industries are therefore urgently seeking energy-efficient mechanisms and management for the beneficial use of fly ash in an ecological and economical manner. This paper offers a comprehensive review of existing knowledge on the major physicochemical and toxicological properties of pulp and paper mill fly ash to assess its suitability for various bound and unbound applications. The current state of various methods used for the valorization of pulp and paper mill fly ash into more sustainable geomaterials is briefly discussed. This paper also presents promising and innovative applications for pulp and paper mill fly ash, with particular reference to agriculture and forestry, the construction and geotechnical industries, and the immobilization of contaminants. It was identified from a literature review that modified pulp and paper mill fly ash can be environmentally and economically advantageous over commercial coal-based fly ash in various sustainable applications.
Supplementary document for Internal nanocavity based high-resolution and stable structural colours fabricated by laser printing - 5058498.pdf
Creators: name: Wang, Lei
name: Ma, Lijun
name: Zhao, Qiuling
name: Wang, Shu
name: Wang, Xiaofeng
name: Zhang, Chen
name: Wang, Xia
name: Liu, Qian
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Revised supplemental information
Accelerating the rate of astronomical discovery with GPU-powered clusters
Creators: name: Fluke, Christopher
Publisher: name: Swinburne
Year: 2024

description: In recent years, the Graphics Processing Unit (GPU) has emerged as a low-cost alternative for high performance computing, enabling impressive speed-ups for a range of scientific computing applications. Early adopters in astronomy are already benefiting in adapting their, codes to take advantage of the GPU's massively parallel processing paradigm. I give an introduction to, and overview of, the use of GPUs in astronomy to date, highlighting the adoption and application trends from the first similar to 100 GPU-related publications in astronomy. I discuss the opportunities and challenges of utilising GPU computing clusters, such as the new Australian GPU supercomputer, gSTAR, for accelerating the rate of astronomical discovery.
The fabrication and optical properties of quantum wires.
Creators: name: Finnie, Paul D.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Physics, Condensed Matter.

description: Chemical beam epitaxy was used to grow GaAs and InP based heterostructures on selectively masked substrates. The natural tendency of crystals to form facets was studied as a function of growth conditions. By exploiting this tendency, patterns were reduced from ${\sim}1$ micron in width to ${\sim}20$ nm in width, and inverted-V crescent quantum wire structures were grown entirely in situ. Photoluminescence spectra were obtained, showing broad multiple peaks which are related to the structure and migration between facets. Redshifts of over 100 meV were obtained for narrow structures. Mesa roughness and PL line width are identified as difficulties for the fabrication technique. A simple analytic model--the only separable model in two dimensions showing geometrical quantum confinement--is developed in the spirit of the Ben-Daniel Duke approximation for a square well. The model is applied to variational estimates for the exciton binding energy in crescent quantum wire structures and is compared to the experimental data.