Additional file 1 of Timing and severity of COVID-19 during pregnancy and risk of preterm birth in the International Registry of Coronavirus Exposure in Pregnancy
Creators: name: Smith, Louisa H.
name: Dollinger, Camille Y.
name: VanderWeele, Tyler J.
name: Wyszynski, Diego F.
name: Hernández-Díaz, Sonia
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Table S1. Descriptive characteristics of eligible participants in the International Registry of Coronavirus Exposure in Pregnancy who enrolled between June 2020 and July 2021 and provided outcomes by July 2021 (n = 5884). Figure S1. Raw cumulative incidence of deliveries after COVID-19 in selected weeks of gestation. COVID-19 negative individuals in a given week are those who are still pregnant at that week. Week 20 refers to all infections at or before week 20. Figure S2. Months since last menstrual period (LMP) at a) enrollment and b) time of symptom onset or test (if negative or positive, symptomatic), for participants who joined while pregnant and within 6 months after pregnancy, stratified by COVID-19 severity. Table S2. Estimates of standardized risks of spontaneous preterm delivery and risk ratios comparing COVID-19 positive vs. negative and severe vs. mild/moderate. Table S3. Estimates of standardized risks of induced preterm delivery and risk ratios comparing COVID-19 positive vs. negative and severe vs. mild/moderate. Table S4. Risk differences for overall, spontaneous, and induced preterm delivery, comparing COVID-19 positive vs. negative and severe vs. mild/moderate. Figure S3. Results from varying the risk window (and corresponding size of reference window) in case-time-control analysis. Table S5. Descriptive characteristics comparing those who provided outcome data and those who did not, but whose pregnancies were presumed completed (i.e., lost to follow-up). Table S6. Comparison of risk ratios from complete-case (as in the main text) and multiply-imputed analyses. Table S7. Estimates from various sensitivity analyses of log-linear analysis. Figure S4. Cumulative deliveries across gestation, estimated in various sensitivity analyses (COVID-positive vs. negative): a) Estimating risks separately for mild and moderate severity groups; b) Finer modeling of the discrete-time hazard of delivery; c) Excluding participants who joined after completion of pregnancy; d) Excluding participants who tested negative within two weeks before delivery (i.e., routine delivery testing). Figure S5. Cumulative deliveries across gestation, estimated in various sensitivity analyses (COVID-19 severity): a) Estimating risks separately for mild and moderate severity groups; b) Finer modeling of the discrete-time hazard of delivery; c) Excluding participants who joined after completion of pregnancy; d) Excluding participants who tested negative within two weeks before delivery (i.e., routine delivery testing). Table S8. Estimates of standardized risks of very preterm delivery (&lt; 34 weeks) and risk ratios comparing COVID-19 positive vs. negative and severe vs. mild/moderate. Table S9. Estimates of standardized risks of spontaneous very preterm delivery (&lt; 34 weeks) and risk ratios comparing COVID-19 positive vs. negative and severe vs. mild/moderate. Table S10. Estimates of standardized risks of induced very preterm delivery (&lt; 34 weeks) and risk ratios comparing COVID-19 positive vs. negative and severe vs. mild/moderate. Table S11. Distribution of symptoms and healthcare-related actions across levels of COVID-19 severity.