cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
DNMT3a Epigenetic Program Regulates the HIF-2alpha Oxygen Sensing Machinery
Creators: name: Lachance, Gabriel
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Tumor hypoxia
Epigenetic

description: Epigenetic regulation of gene expression by DNA methylation plays a central role in the maintenance of cellular homeostasis. Here we present evidence implicating the DNA methylation program in the regulation of hypoxia-inducible factor (HIF) oxygen-sensing machinery. We show that DNA methyltransferase 3a (DNMT3a) methylates and silences the HIF-2alpha gene (EPAS1) in normal cells. Epigenetic silencing of EPAS1 prevents activation of the HIF-2alpha gene program associated with hypoxic cell growth, thereby limiting the proliferative capacity of cells under low oxygen tension. Naturally occurring defects in DNMT3a, observed in primary tumours and malignant cells, cause the unscheduled activation of EPAS1 in early dysplastic foci. This enables incipient cancer cells to exploit the HIF-2alpha pathway in the hypoxic tumour microenvironment, which is necessary for the formation of cellular masses larger than the oxygen diffusion limit. Reintroduction of DNMT3a in DNMT3a-defective cells restores EPAS1 epigenetic silencing, prevents hypoxic cell growth, and suppresses tumour growth in vivo. In addition, restoring HIF-2alpha expression in DNMT3a-reintroduced cancer cells restores full tumorigenic potential, including the capacity to traverse the hypoxic barrier. These data support a tumour-suppressive role for DNMT3a as an epigenetic regulator of the HIF-2alpha oxygen-sensing pathway and the cellular response to hypoxia.
Origin and Architecture of Deep-water Levee Deposits: Insight from the Ancient Rock Record and Experiments
Creators: name: Khan, Zishann
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: Levees
Deep-water
Turbidites
Seismic modelling
Compaction
Channel-levee evolution
Windermere Supergroup
Isaac Formation

description: Although levee deposits make up a significant part of modern and ancient deep-marine slope systems, details of their internal lithological composition and stratal architecture remain poorly documented. At the Castle Creek study area, strata of the Neoproterozoic Isaac Formation (Windermere Supergroup) crop out superbly in a kilometre-scale section through a sinuous deep-water channel-levee system (ICC3). Levee deposits near the outer bend of the channel consist of sandstone-rich (sandstone-to-mudstone ratio of 68:42), medium- to thick-bedded turbidites interstratified with thinly-bedded turbidites. Structureless sandstone (Ta), planar laminated sandstone (Tb), non-climbing ripple cross-stratified sandstone (Tc) and massive and laminated siltstone (Td) are common. Thick beds generally thicken and then thin and fine laterally over about 300 m. Thin-bedded strata, in contrast, thin and fine negligibly over similar distances. In the distal part of the outer-bend levee (up to 700 m laterally away from the channel) strata consist predominantly of thin-bedded Tcd turbidites with a much lower sandstone-to-mudstone ratio (35:65). On the opposite side of the channel, inner-bend levee deposits are mudstone-rich, locally as low as 15:85, and consist mostly of thin-bedded, Tcd turbidites, although thicker-bedded, Ta-d turbidites are more common in the lower part of the section. Lateral thinning and fining of beds is more rapid than their outer-bend counterpart. Levee deposits of ICC3 comprise three stacked decametre-scale upward-thinning and -fining successions. Each is interpreted to record a depositional history consisting of lateral channel migration, levee deposition, channel filling, and distal levee deposition. During the early stage of increasing levee relief it is proposed that the termini of individual beds progressively backstep towards the channel margin resulting in an overall lateral thinning of the stratal profile. This interpretation notably contrasts the common assumption that levee morphology is the result of the vertical stacking of beds that dip. In addition to field studies, laboratory experiments were conducted to determine the depositional threshold of non-climbing ripple cross-stratification, which is common in levee strata of ICC3. It was determined that non-climbing ripples form when bed aggradation rates are less than 0.015 cm/sec, and most probably in flows made up of poorly sorted sediment.
A critical review of bioaccumulation and biotransformation of organic chemicals in birds
Creators: name: Deutsch, Markus
name: Kuo, Dave T. F.
name: Rattner, Barnett A.
name: Marteinson, Sarah C.
name: Treu, Gabriele
Publisher: name: My University
Year: 2022
Subjects: Bioakkumulation
Biomonitoring
Lagerstättenerkundung
Ornithologie

description: A literature review of bioaccumulation and biotransformation of organic chemicals in birds was undertaken, aiming to support scoping and prioritization of future research. The objectives were to characterize available bioaccumulation/biotransformation data, identify knowledge gaps, determine how extant data can be used, and explore the strategy and steps forward. An intermediate approach balanced between expediency and rigor was taken given the vastness of the literature. Following a critical review of [500 peer-reviewed studies, [25,000 data entries and 2 million information bytes were compiled on [700 organic compounds for * 320 wild species and 60 domestic breeds of birds. These data were organized into themed databases on bioaccumulation and biotransformation, field survey, microsomal enzyme activity, metabolic pathway, and bird taxonomy and diet. Significant data gaps were identified in all databases at multiple levels. Biotransformation characterization was largely fragmented over metabolite/pathway identification and characterization of enzyme activity or biotransformation kinetics. Limited biotransformation kinetic data constrained development of an avian biotransformation model. A substantial shortage of in vivo biotransformation kinetics has been observed as most reported rate constants were derived in vitro. No metric comprehensively captured all key contaminant classes or chemical groups to support broad-scope modeling of bioaccumulation or biotransformation. However, metrics such as biota-feed accumulation factor, maximum transfer factor, and total elimination rate constant were more readily usable for modeling or benchmarking than other reviewed parameters. Analysis demonstrated the lack of bioaccumulation/biotransformation characterization of shorebirds, seabirds, and raptors. In the study of bioaccumulation and biotransformation of organic chemicals in birds, this review revealed the need for greater chemical and avian species diversity, chemical measurements in environmental media, basic biometrics and exposure conditions, multiple tissues/matrices sampling, and further exploration on biotransformation. Limitations of classical bioaccumulation metrics and current research strategies used in bird studies were also discussed. Forward-looking research strategies were proposed: adopting a chemical roadmap for future investigations, integrating existing biomonitoring data, gap-filling with non-testing approaches, improving data reporting practices, expanding field sampling scopes, bridging existing models and theories, exploring biotransformation via avian genomics, and establishing an online data repository. The Author(s) 2022
L’Androgino e il simbolo
Creators: name: Sivelli, Sara
Publisher: name: Università degli Studi di Milano
Year: 2010

description: Da sempre il mito dell’androgino è stato al centro dell’interesse dell’uomo, come protagonista indiscusso delle mitologie arcaiche o in quanto oggetto di rappresentazioni artistiche disseminate sullo sfondo di varie epoche storiche. Grazie alla sua plasticità semantica sembra essere evocato ogni qual volta venga posta la domanda sull’origine dell’uomo. Sotto numerosi punti di vista, infatti, può apparire come simbolo dei simboli in virtù della sua predisposizione a rappresentare ogni sorta di dualità essenziale, al di là della semplice polarità sessuale. Viene gelo-samente custodito nel seno di ogni cultura proprio perché la sua indicibi-le natura appartiene a ogni uomo: si plasma con la medesima materia, onirica e impalpabile, di cui è fatto l’inconscio.
description: Itinera, N° 1 (2011)
New insights from the biogas microbiome by comprehensive genome-resolved metagenomics of nearly 1600 species originating from multiple anaerobic digesters
Creators: name: Campanaro, Stefano
name: Treu, Laura
name: Rodriguez-R, Luis M
name: Kovalovszki, Adam
name: Ziels, Ryan M
name: Maus, Irena
name: Zhu, Xinyu
name: Kougias, Panagiotis G
name: Basile, Arianna
name: Luo, Gang
name: Schlüter, Andreas
name: Konstantinidis, Konstantinos T
name: Angelidaki, Irini
Publisher: name: BioMed Central
Year: 2020

description: Background: Microorganisms in biogas reactors are essential for degradation of organic matter and methane production. However, a comprehensive genome-centric comparison, including relevant metadata for each sample, is still needed to identify the globally distributed biogas community members and serve as a reliable repository. Results: Here, 134 publicly available metagenomes derived from different biogas reactors were used to recover 1635 metagenome-assembled genomes (MAGs) representing different biogas bacterial and archaeal species. All genomes were estimated to be > 50% complete and nearly half ≥ 90% complete with ≤ 5% contamination. In most samples, specialized microbial communities were established, while only a few taxa were widespread among the different reactor systems. Metabolic reconstruction of the MAGs enabled the prediction of functional traits related to biomass degradation and methane production from waste biomass. An extensive evaluation of the replication index provided an estimation of the growth dynamics for microbes involved in different steps of the food chain. Conclusions: The outcome of this study highlights a high flexibility of the biogas microbiome, allowing it to modify its composition and to adapt to the environmental conditions, including temperatures and a wide range of substrates. Our findings enhance our mechanistic understanding of the AD microbiome and substantially extend the existing repository of genomes. The established database represents a relevant resource for future studies related to this engineered ecosystem.
Elementi per un’estetica dell’immagine egizia
Creators: name: Bellini, Manuele
Publisher: name: Università degli Studi di Milano
Year: 2010

description: L’immagine egizia, che si declina nelle forme dell’arte e nella scrittura geroglifica, non è né rappresentazione o imitazione della natura né e-spressione, ma creazione di una realtà altra parallela a quella sensibile: la sua funzione è performativa. L’immagine, lungi dall’essere phantasma, vive di per sé ed è una realtà concreta da usarsi, non una realtà trasfigu-rata da fruirsi. È un simulacro che va a supplire l’oggetto cui somiglia –un esempio è dato dalle libagioni dipinte sulle stele funerarie. Fine dell’artista non è la mimesis, ma la ricostruzione, secondo un canone, di una realtà differente, che si anima per magia. L’immagine nasce nella sepoltura e il suo fine non è solo il tramandare la memoria del defunto, ma prolungare la vita: la morte, tradotta in immagine, non solo ricorda la vita che è stata, ma torna a essere vita e l’invisibile, non più confinato nel regno degli inferi e delle ombre, si fa visibile, mostrando la sua mai perduta realtà. Ora, l’assenza di una dialettica tra immagine e realtà impedisce la fioritura di una riflessione filosofica, di un pensiero astratto, perché ciò che i geroglifici, che sono pittogrammi fonetici, indicano trapassa subito nell’oggetto senza che possa costituirsi come concetto. Tuttavia, a gli egizi questo non interessa: l’immagine, ipostatizzando ciò che designa, lo sacralizza perché essa è al servizio di un’ideologia. Ma sacralizzare non è solo propagandare, bensì inserire un oggetto nell’ordine del cosmo, prolungando l’opera di creazione del Demiurgo che la società si sforza di mantenere attraverso l’azione del Faraone.
description: Itinera, N° 1 (2011)
Umanità e alterità in Montaigne e nei moderni
Creators: name: Bonicalzi, Sofia
Publisher: name: Università degli Studi di Milano
Year: 2010

description: Nei secoli successivi alla scoperta dell’America gli intellettuali europei si impegnarono in un complesso dibattito riguardante la natura dei popoli recentemente scoperti e l’ammissibilità della conquista. Nella riflessione di Montaigne, a fronte di una critica serrata della civiltà europea, il nuo-vo mondo diventa il paradigma di un’umanità diversa e nella quale forse si può ancora sperare, ma l’atteggiamento prevalente fra ’500 e ’700 ri-sultò piuttosto caratterizzato da chiusura e incomprensione e si tradusse nell’elaborazione di fantasiose leggende che dessero conto dell’origine e della diffusione degli indios. Se per Lévi-Strauss ciò può essere ricondot-to al senso di profondo smarrimento che colse gli occidentali trovatisi di fronte ai popoli nudi, per Gliozzi le diverse proposte teoriche avrebbero piuttosto rappresentato la copertura ideologica della conquista armata e dell’apparato coloniale, ingrediente determinante nell’affermazione del nuovo sistema di produzione borghese.
description: Itinera, N° 1 (2011)
La parola al silenzio. Un rimedio alla parola parlata
Creators: name: Candia, Roberta
Publisher: name: Università degli Studi di Milano
Year: 2010

description: Il panorama estetico contemporaneo sembra prestarsi ad accogliere ma-nifestazioni artistiche caratterizzate dalla completa estrinsecazione, ver-bale e non, dei significati che veicolano, annullando così l’aspetto simboli-co e misterioso dell’opera d’arte e fornendo ai fruitori interpretazioni preconfezionate della stessa. È il fenomeno del kitsch, che mortifica il potere evocativo dell’arte, trasformandone i prodotti in forme non più che artigianali e in beni di immediato consumo. A questa tendenza cercano di fare fronte, attraverso la potenza granitica del silenzio, alcuni tentativi di pochi ma significativi nomi, legati ad ambiti artistici differenti, con la volontà di restituire vigore e autenticità alla parola abusata, risemantizzandola.
description: Itinera, N° 1 (2011)
Establishment of multi-omics resources for the giant triton snail and the silver- lipped pearl oyster
Creators: name: Klein, Anne
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2022
Subjects: omics
Gastropods
P. maxima
Bioinformatics and computational biology
Other biological sciences

description: The establishment of a human genome and associated omics data has provided an essential resource to biological researchers. Since then, the fast progression of sequencing technologies has driven cost reductions, improved accessibility, technological progress and availability of supporting tools and resources, filling the living world of omics data. However, within the phylum Mollusca, there is still a paucity of omics data that may be explained by relative differences in economic importance. This PhD project aimed to generate omics resources for two molluscan species, which could facilitate better understanding of their molecular biology. They include the giant triton snail (Charonia tritonis), a gastropod, and the Silver-lipped pearl oyster (Pinctada maxima), a bivalve.
Human Biomonitoring of "new" contaminants: Sub-Project 2 - Screening of target and non-target contaminants in human blood and urine
Creators: name: Plaßmann, Merle
name: Brack, Werner
name: Krauss, Martin
Publisher: name: My University
Year: 2016
Subjects: subject: Umweltchemikalien
subject: Blut
subject: Human monitoring
subject: environmental contaminants
subject: non-target screening
subject: human blood
subject: human urine
subject: Gesundheit
subject: Health

description: The development of screening methods has increased over the last years due to the possibility to search for multiple targets and suspected and so far unknown compounds. Non-target screening has mostly been restricted to water and food samples, only a few studies have shown an application to biological samples. Thus the objective of this project was to develop and apply a non-target screening method to human urine and blood samples. The method development was done by using a broad range of target analytes from various chemical groups, like aromatic amines, industrial chemicals, perfluorinated alkyl acids and UV filters. For sample preparation the QuEChERS (quick, easy, cheap, effective, rugged and safe) method was tested, samples were extracted using acetonitrile and salts for phase separation, followed by a sample clean-up using dispersive solid phase extraction. Urine samples were also directly injected into the LC-HRMS.
Quelle: Verlagsinformation
description: The development of screening methods has increased over the last years due to the possibility to search for multiple targets and suspected and so far unknown compounds. Non-target screening has mostly been restricted to water and food samples, only a few studies have shown an application to biological samples. Thus the objective of this project was to develop and apply a non-target screening method to human urine and blood samples. The method development was done by using a broad range of target analytes from various chemical groups, like aromatic amines, industrial chemicals, perfluorinated alkyl acids and UV filters. For sample preparation the QuEChERS (quick, easy, cheap, effective, rugged and safe) method was tested, samples were extracted using acetonitrile and salts for phase separation, followed by a sample clean-up using dispersive solid phase extraction. Urine samples were also directly injected into the LC-HRMS.
Molecular analysis of the medicinally significant plant Fontainea picrosperma (Euphorbiaceae) with insights into the diterpenoid biosynthesis pathway
Creators: name: Mitu, Shahida Akter
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2021
Subjects: Anti cancer
Tigilanol tiglate
Biosynthesis pathway
Cytochrome P450

description: Euphorbiaceae is a large and diverse family of herbs, shrubs and trees that includes species of considerable economic importance as sources of food, cosmetics and medicines. One member of this family, Fontainea picrosperma, is the source plant for the diterpene ester tigilanol tiglate (EBC-46), a natural product that is of particular current interest due to its effectiveness as a local treatment for a range of cancers in humans and companion animals. Recently, EBC-46 was approved by regulatory authorities in Europe and the USA as a veterinary pharmaceutical for the treatment of non-metastatic canine mast cell tumours. Prior to this PhD study, there was no information regarding the molecular biosynthesis of EBC-46. This was likely due to: (1) the absence of gene information within Fontainea species, (2) little understanding of the location (tissue) of EBC-46 production, (3) a general lack of understanding into the biosynthesis of related tigliane diterpene esters, and (4) no existing transgenic plant gene expression system at the University of the Sunshine Coast (USC). The goal of this PhD project was to significantly expand knowledge of the genes present and used by F. picrosperma, and specifically those involved in the biosynthesis of tigliane esters such EBC-46. This data will provide an excellent resource for subsequent functional investigations and ultimately establish large scale microbial platforms devoted to the production of EBC-46.
Supplementary document for Beam propagation simulation of phased laser arrays with atmospheric perturbations - 5235366.pdf
Creators: name: Hettel, Will
name: Meinhold, Peter
name: Suen, Jonathan
name: Srinivasan, Prashant
name: Krogen, Peter
name: Wirth, Allan
name: Lubin, Philip
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Lasers and Quantum Electronics
Atmospheric Dynamics
Numerical Computation

description: Details of adaptive optics models, calculations, simulation parameters and atmospheric modeling.
Task Oriented Privacy-preserving (TOP) Technologies Using Automatic Feature Selection
Creators: name: Jafer, Yasser
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Task Oriented Privacy (TOP)
Privacy
Data Mining
Data Publishing
Feature Selection
Privacy-aware Wrappers
Privacy-aware Filters
Privacy-aware Evaluation Measure for Feature Selection

description: A large amount of digital information collected and stored in datasets creates vast opportunities for knowledge discovery and data mining. These datasets, however, may contain sensitive information about individuals and, therefore, it is imperative to ensure that their privacy is protected. Most research in the area of privacy preserving data publishing does not make any assumptions about an intended analysis task applied on the dataset. In many domains such as healthcare, finance, etc; however, it is possible to identify the analysis task beforehand. Incorporating such knowledge of the ultimate analysis task may improve the quality of the anonymized data while protecting the privacy of individuals. Furthermore, the existing research which consider the ultimate analysis task (e.g., classification) is not suitable for high-dimensional data. We show that automatic feature selection (which is a well-known dimensionality reduction technique) can be utilized in order to consider both aspects of privacy and utility simultaneously. In doing so, we show that feature selection can enhance existing privacy preserving techniques addressing k-anonymity and differential privacy and protect privacy while reducing the amount of modifications applied to the dataset; hence, in most of the cases achieving higher utility. We consider incorporating the concept of privacy-by-design within the feature selection process. We propose techniques that turn filter-based and wrapper-based feature selection into privacy-aware processes. To this end, we build a layer of privacy on top of regular feature selection process and obtain a privacy preserving feature selection that is not only guided by accuracy but also the amount of protected private information. In addition to considering privacy after feature selection we introduce a framework for a privacy-aware feature selection evaluation measure. That is, we incorporate privacy during feature selection and obtain a list of candidate privacy-aware attribute subsets that consider (and satisfy) both efficacy and privacy requirements simultaneously. Finally, we propose a multi-dimensional, privacy-aware evaluation function which incorporates efficacy, privacy, and dimensionality weights and enables the data holder to obtain a best attribute subset according to its preferences.
Che fine ha fatto il futuro?
Creators: name: Candia, Roberta
Publisher: name: Università degli Studi di Milano
Year: 2010

description: Recensione di Marc Augé, Che fine ha fatto il futuro? Dai non luoghi al non tempo, trad. it. di G. Lagomarsino, Eleuthera, Milano 2009, pp. 112.
description: Itinera, N° 1 (2011)
Edipus: lo scarrozzante e Dioniso. Variazioni sul mito da Giovanni Testori
Creators: name: Gennari, Alessia
Publisher: name: Università degli Studi di Milano
Year: 2010

description: Tra le molte riscritture contemporanee del mito di Edipo, quella di Giovanni Testori, terzo e conclusivo capitolo della Trilogia degli Scarrozzanti, si evidenzia certamente per i suoi smaccati caratteri di originalità e autonomia dal modello. Non dunque una ri-scrittura, ma una scrittura che al mito ruba i presupposti per un’ elaborazione del tutto nuova dal punto di vista della vicenda, della forma e del linguaggio. Il saggio si propone di analizzare l’Edipus alla luce del modello sofocleo, evidenziandone i caratteri di continuità ma soprattutto mettendo in luce i punti di rottura con una tradizione che è un solco lungo cui Testori inizia il proprio cammino e da cui subito fuoriesce per prendere un’altra strada: la strada tortuosa di un autore che ha fatto della sperimentazione formale e linguistica un caposaldo della propria poetica non allineata.
description: Itinera, N° 1 (2011)
Dramma e materia. Sul «materialismo assoluto» di Antonin Artaud
Creators: name: Cambria, Florinda
Publisher: name: Università degli Studi di Milano
Year: 2012

description: Una incursione nei Messaggi rivoluzionari, composti da Artaud durante il suo soggiorno in Messico nel 1936, permette di delineare la prospettiva di un materialismo inedito, libero da astratte contrapposizioni a spiritualismi di sorta, e radicato nella natura eminentemente "drammatica" dell'agire umano.

description: Nóema, N° 3 (2012): Ricerche
Supplementary document for Beam propagation simulation of phased laser arrays with atmospheric perturbations - 5235366.pdf
Creators: name: Hettel, Will
name: Meinhold, Peter
name: Suen, Jonathan
name: Srinivasan, Prashant
name: Krogen, Peter
name: Wirth, Allan
name: Lubin, Philip
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Lasers and Quantum Electronics
Atmospheric Dynamics
Numerical Computation

description: Details of adaptive optics models, calculations, simulation parameters and atmospheric modeling.
Certainty through Flexibility: Intelligence and Paramilitarization in Canadian Public Order Policing
Creators: name: Cartier, Brad
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: media
policing protest
public order policing
Vancouver Olympics
Toronto G20 Summit
Canada policing

description: This case study explores public order policing at the Vancouver Olympics and G20 Summit in Toronto. The source material is drawn from media coverage of these events. These cases are analyzed using prior theoretical works in order policing in order to achieve two research goals: to discover which theory best explains police actions and the extent of and reasons explaining the involvement of other government agencies in securing protest events in Canada. Using pattern matching methodology, it was found that no one particular theory is best at explaining events at the two cases, rather components of various theories provided the most useful insight. The components of these theories that need to be amalgamated through analytic induction are: the use of intelligence functions; police flexibility; as well as paramilitarization tactics. Finally, it was found that there was a noticeable presence and integration of other government agencies involved in securing both events.
An Oral History of Inspectors of Primary Schools in Victoria: 1960-1983
Creators: name: Gray, Norma
name: Gray, Norma
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2012
Subjects: oral history
school inspectors
school inspection
teacher assessment
school evaluation

description: The aim of this study was to develop an understanding of the roles of, and contributions made by, District Inspectors of Primary Schools in the State of Victoria, Australia. The functions, responsibilities and strategies of the inspectorial system in the State of Victoria were introduced during the Colonial era and from its inception the system remained largely unchanged until 1983 when the office of the Inspector was abolished. The multiple, conflicting and confused roles of the inspectorial system developed over the century of its existence and the organizational cultures of regions now responsible for the inspectorial system complicated the work of the Inspectors. Thus the question of how effectively the inspectorial system worked and how it served its functions needs to be addressed, particularly how it enhanced the educational standards and teaching profession.
Link to Questionnaire Based Projects: Student Guidance
Creators: name: Hubbard, Katharine
Publisher: name: figshare
Year: 2020
Subjects: Uncategorized

description: A student facing guide to questionnaire based projects run by the Department of Biological and Marine Sciences at the University of Hull.
The guide includes advice on writing questionnaires, ethical considerations and an example methods+results section for Likert style questionnaire data
The Reconstruction of User-Interactions from HTTP traces for RIAs
Creators: name: Baghbanzadeh, Sara
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: user-interactions
HTTP traffic
replaying
reconstruction

description: A user using a Web application generates HTTP traffic which can be captured and logged to be used for further analysis such as finding potential security holes. This document provides a method to reconstruct user-interactions from HTTP network traffic with a specific focus on RIAs. The only input provided is the full, unaltered HTTP network traffic of the original user-session. This thesis presents a system to replay HTTP trace for reconstructing the user-interactions using a programmable Web browser that is used to simulate user's actions and to execute client-side scripts. The experimental results show that the proposed solution in this thesis leads to a system which has a good performance in reconstructing user-interactions. The system performs an automated reconstruction of the user-interactions which reconstructs every DOM state that has been visited by the user during the user-session and the actions taken by the user, including user-inputs provided by the user.
Mobilitätsumfrage des Umweltbundesamtes 2017
Creators: name: Janßen, Antje
name: Bänfer, Dirk
name: Halfter, Antje
Publisher: name: My University
Year: 2018
Subjects: subject: Nachhaltige Mobilität
subject: Mobilitätsmanagement
subject: Umweltbundesamt
subject: Dienstreise
subject: Das UBA
subject: Verkehr

description: Das ⁠UBA⁠ befragte zum vierten Mal seine Beschäftigten zu ihren Arbeitswegen und Dienstreisen. 68 Prozent der Beschäftigten kommen zu Fuß, mit dem Rad oder Bus und Bahn zur Arbeit. Der Radverkehrsanteil bei den Arbeitswegen liegt bei 25 Prozent. Er ist knapp dreimal höher als im Bundesdurchschnitt. Der Anteil am ÖPNV und der Bahn hat im Vergleich zum Jahr 2013 leicht zugenommen. Dies hat führte dazu, dass die durchschnittlichen ⁠CO2⁠-Emissionen pro Arbeitswoche und Beschäftigten gegenüber 2013 um 4,2 Prozent gesunken sind. Wir fördern im UBA seit  über 12 Jahren mit gezielten Maßnahmen die Nutzung umweltverträglicher Verkehrsmittel. Wie wir dies tun, erfahren Sie aus unserer aktuellen Umfrage.
Supplementary document for Amplitude-modulation-type multi-ring mask for two-photon excitation scanning microscopy - 5235582.pdf
Creators: name: Matsumoto, Naoya
name: Konno, Alu
name: Watanabe, Koyo
name: Inoue, Takashi
name: Okazaki, Shigetoshi
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: supplemental document
Fractional Flow Reserve Derived from Coronary Computed Tomography Angiography Safely Defers Invasive Coronary Angiography in Patients with Stable Coronary Artery Disease
Creators: name: Rabbat, Mark
name: Leipsic, Jonathon
name: Bax, Jeroen
name: Kauh, Brian
name: Verma, Rina
name: Doukas, Demetrios
name: Allen, Sorcha
name: Pontone, Gianluca
name: Wilber, David
name: Mathew, Verghese
name: Rogers, Campbell
name: Lopez, John
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2020

description: Objectives: In the United States, the real-world feasibility and outcome of using fractional flow reserve from coronary computed tomography angiography (FFRCT) is unknown. We sought to determine whether a strategy that combined coronary computed tomography angiography (CTA) and FFRCT could safely reduce the need for invasive coronary angiography (ICA), as compared to coronary CTA alone. Methods: The study included 387 consecutive patients with suspected CAD referred for coronary CTA with selective FFRCT and 44 control patients who underwent CTA alone. Lesions with 30–90% diameter stenoses were considered of indeterminate hemodynamic significance and underwent FFRCT. Nadir FFRCT ≤ 0.80 was positive. The rate of patients having ICA, revascularization and major adverse cardiac events were recorded. Results: Using coronary CTA and selective FFRCT, 121 patients (32%) had at least one vessel with ≥50% diameter stenosis; 67/121 (55%) patients had at least one vessel with FFRCT ≤ 0.80; 55/121 (45%) underwent ICA; and 34 were revascularized. The proportion of ICA patients undergoing revascularization was 62% (34 of 55). The number of patients with vessels with 30–50% diameter of stenosis was 90 (23%); 28/90 (31%) patients had at least one vessel with FFRCT ≤ 0.80; 8/90 (9%) underwent ICA; and five were revascularized. In our institutional practice, compared to coronary CTA alone, coronary CTA with selective FFRCT reduced the rates of ICA (45% vs. 80%) for those with obstructive CAD. Using coronary CTA with selective FFRCT, no major adverse cardiac events occurred over a mean follow-up of 440 days. Conclusion: FFRCT safely deferred ICA in patients with CAD of indeterminate hemodynamic significance. A high proportion of those who underwent ICA were revascularized.
Searching for Rivers
Creators: name: Prentice, Tully
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2024
Subjects: W. H. R. Rivers
biography
genealogy
prosopography
decentring
experimental biography
Queensland
Creative and professional writing
Other creative arts and writing

description: This exegesis and creative work contributes to knowledge by creatively enacting the naïve and ultimately impossible pursuit of freeing a biographical subject, in this case British polymath William Halse Rivers Rivers (1864–1922), from creative conjecture and illusion. The exegesis is, principally, a prospective account of a research journey. It establishes what is known about W.H.R. Rivers, and through a variety of methods, seeks insights to further that knowledge. Primary records and contemporaneous sources from within the archives are interrogated for generational and other vital links. The genealogical method proved essential for determining family connections and origins, and prosopography indispensable in several investigations for establishing common characteristics. A finding from this research is that, for practitioners, immersion in the archives may produce results that influence the intended direction of a creative work. Supplementary, or ghostly, voices from the past, transformed the anticipated pragmatic biography into a narrative in which the original subject, Rivers, was decentred. A creative composition appropriated by ghosts demanded an accommodating space. In tracing such, various potential frameworks of the biographical genre were examined, and both irony and paradox consistent with that of the creative artefact were employed in experimentation with form. Practice-led, the creative artefact develops the outcome of this process. It demonstrates the results of the ‘small world’ model of research (six degrees of separation), and the meta-narrative complexities of adapting archival voices to the historical account of a life.
Changes in Circulation and Particle Scavenging in the Amerasian Basin of the Arctic Ocean over the Last Three Decades Inferred from the Water Column Distribution of Geochemical Tracers
Creators: name: Grenier, Mélanie
name: François, Roger
name: Soon, Maureen
name: Van Der Loeff, Michiel Rutgers
name: Yu, Xiaoxin
name: Valk, Ole
name: Not, Christelle
name: Moran, S. Bradley
name: Edwards, R. Lawrence
name: Lu, Yanbin
name: Lepore, Kate
name: Allen, Susan
Publisher: name: American Geophysical Union
Year: 2022

description: Since the 1980–1990s, international research efforts have augmented our knowledge of the physical and chemical properties of the Arctic Ocean water masses, and recent studies have documented changes. Understanding the processes responsible for these changes is necessary to be able to forecast the local and global consequences of these property evolutions on climate. The present work investigates the distributions of geochemical tracers of particle fluxes and circulation in the Amerasian Basin and their temporal evolution over the last three decades (from stations visited between 1983 and 2015). Profiles of ²³⁰‐thorium (²³⁰Th) and ²³¹‐protactinium (²³¹Pa) concentrations and neodymium isotopes (expressed as εNd) measured in the Amerasian Basin prior to 2000 are compared to a new, post‐2000s data set. The comparison shows a large scale decrease in dissolved ²³⁰Th and ²³¹Pa concentrations, suggesting intensification of scavenging by particle flux, especially in coastal areas. Higher productivity and sediment resuspension from the shelves appear responsible for the concentration decrease along the margins. In the basin interior, increased lateral exchanges with the boundary circulation also contribute to the decrease in concentration. This study illustrates how dissolved ²³⁰Th and ²³¹Pa, with εNd support, can provide unique insights not only into changes in particle flux but also into the evolution of ocean circulation and mixing.
Factors influencing meaningful nutrition information provision to pregnant women in high resource settings: A qualitative meta-synthesis protocol
Creators: name: Maher, Judith
name: Kearney, Lauren
name: McLauchlan, Michelle
Publisher: name: University of the Sunshine Coast
Year: 2023

description: Review question:
description: What do pregnant women perceive meaningful nutrition information provision to be and what recommendations arise from qualitative study findings?
Questionnaire Based Projects: Student Guidance
Creators: name: Hubbard, Katharine
Publisher: name: figshare
Year: 2020
Subjects: Uncategorized

description: A student facing guide to questionnaire based projects run by the Department of Biological and Marine Sciences at the University of Hull.
The guide includes advice on writing questionnaires, ethical considerations and an example methods+results section for Likert style questionnaire data
Predicting the geographic distributions of Macadamia integrifolia and Macadamia ternifolia
Creators: name: Powell, Michael A
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2009
Subjects: habitat fragmentation
predictive models
spatial predictions
rare species

description: This work aims to investigate whether compiled ecological and environmental data can be used to successfully predict the geographic distributions of habitat of regionally rare and threatened plants using two Macadamia species as a case study. The thesis focuses on the predicted spatial distribution of the realised environmental niche of Macadamia integrifolia, and M. ternifolia, which are endemic to lowland subtropical rainforests of southeast Queensland, Australia. Both species are classified as vulnerable nationally and at a state level. M. integrifolia is the primary source of cultivars used by the Macadamia nut industry. The species insitu conservation is important for maintenance and adaptive evolution of its gene pool, which is a requirement of the international Food and Agricultural Organization agreement to conserve insitu species that are major food crops, to which Australia is a signatory. The study aimed to generate spatially explicit habitat models for M. integrifolia and M. ternifolia in order to assess the extent and pattern of habitat loss that has occurred from widespread past clearing, and for M. integrifolia, to identify the extent of change in predicted distribution of habitat arising from projected climate change.
Identification of Novel Roles for the Survival Motor Neuron (Smn) Protein: Implications on Spinal Muscular Atrophy (SMA) Pathogenesis and Therapy
Creators: name: Bowerman, Melissa
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: spinal muscular atrophy
survival motor neuron protein
actin cytoskeletal dynamics
Rho GTPases
motor neuron
skeletal muscle
neuromuscular junctions
Rho-kinase inhibitors
glucose metabolism
pancreatic islet
profilin
plastin 3

description: Spinal muscular atrophy (SMA) is the leading genetic cause of death of young children. It is an autosomal recessive disease caused by the mutation and/or the deletion within the ubiquitously expressed survival motor neuron 1 (SMN1) gene. SMA pathology is characterized by spinal cord motor neuron degeneration, neuromuscular junction (NMJ) defects and muscular atrophy. Upon disease onset, SMA patients progressively become paralyzed and in the most severe cases, they die due to respiratory complications. Over the years, it has become clear that SMN is a multi-functional protein with important roles in small nuclear ribonucleoprotein (snRNP) assembly, RNA metabolism, axonal outgrowth and pathfinding, mRNA transport as well as in the functional development of NMJs, skeletal muscle and cardiac muscle. However, it remains unclear which of these functions, and the respective perturbed molecular pathways, dictate SMA pathogenesis. Here, we have established Smn-depleted PC12 cells and an intermediate SMA mouse model to characterize a role for Smn in the regulation of actin cytoskeleton dynamics. We find that Smn depletion results in the increased expression of profilin IIa and active RhoA (RhoA-GTP) as well as the decreased expression of plastin 3 and Cdc42. Importantly, the inhibition of rho-kinase (ROCK), a direct downstream regulator of RhoA, significantly increased the lifespan of SMA mice and shows beneficial potential as a therapeutic strategy for SMA. In an addition, we have uncovered a muscle- and motor neuron-independent role for SMN in the regulation of pancreatic development and glucose metabolism in SMA mice and type 1 SMA patients. This finding highlights the importance of combining a glucose tolerance assessment of SMA patients with their existing clinical care management. Thus, our work has uncovered two novel and equally important roles for the SMN protein, both of which contribute significantly to SMA pathogenesis.
title: Investition in eine innovative Anlagentechnologie zum erstmaligen Recycling von Schweröl zu Basisöl, Heizöl und Petrolkoks
title: Investition in eine innovative Anlagentechnologie zum erstmaligen Recycling von Schweröl zu Basisöl, Heizöl und Petrolkoks
titleType: AlternativeTitle
title: Investment in an innovative plant technology for the first-time recycling of heavy oil to base oil, light heating oil, and petroleum coke
titleType: AlternativeTitle
Creators: name: Schüppel, Andreas
Publisher: name: My University
Year: 2020
Subjects: Heizöl [schwer]
Recycling
Ressourceneffizienz

description: Als erstes Unternehmen in der Branche ist es der PURALUBE GmbH gelungen, umweltschädliches Schweröl in nahezu schwefelfreies Basisöl, Leichtes Heizöl und Petrolkoks im sogenannten HyRes TM-Verfahren aufzubereiten. Diese Technologie ermöglicht es, Schweröl mit hohen Schwefelgehalten nicht mehr thermisch verwerten zu müssen, sondern dieses recyceln zu können, wodurch sich kumuliert jährlich nahezu 27.000 Tonnen CO2-Äquivalente pro Anlage einsparen lassen. Zudem wird durch dieses Verfahren ein wesentlicher Beitrag zum Abbau der immensen Überbestände von Schweröl geleistet, nachdem dieses im Zuge der Verschärfung der Emissionsrichtlinien in der Schifffahrt aufgrund dessen hohen Schwefelgehalts als Brennstoff nicht mehr uneingeschränkt verwendet werden darf. Quelle: Forschungsbericht
description: As the first company in the industry, PURALUBE GmbH has succeeded in converting environmentally harmful heavy fuel oil into sulfur-free base oil, light heating oil, and petrol coke using the so-called HyRes TM process. This technology makes it possible to recycle heavy fuel oil with a high sulfur content instead of using it thermally, which saves up to 27,000 tons of CO2 equivalents per plant annually. In addition, this process makes a significant contribution to reducing the immense surplus of heavy fuel oil, which can no longer be used as a fuel without restrictions due to its high sulfur content as a result of the tightening of emission guidelines in shipping. Quelle: Forschungsbericht
Assessing Specialized Translation In Academic Contexts: A Case Study
Creators: name: Grego, Kim
Publisher: name: Università degli  Studi di Milano
Year: 2012

description: This paper discusses translation assessment, first of all by briefly outlining the topic, then by restricting the reflection to specialized translation in didactic contexts and, finally, by discussing how to determine assessment criteria in one specific academic case, the ‘English specialized translation’ course of the ‘Lingue moderne per la comunicazione e la cooperazione internazionale’ Master’s programme of the University of Milan, Italy. Both generic (common to all Master’s programmes in the same ministerial class) and specific (typical of this course) factors were listed, examined and summed up in a preliminary study that may be used as the basis for developing a possible translation assessment model applicable to the case considered.

description: Altre Modernità, 2012: Traduzione e riscrittura
Directing and characterizing silicon nanocrystal self-assembly
Creators: name: Guillaussier, Adrien Camille
Publisher: name: The University of Texas at Austin
Year: 2018
Subjects: Silicon nanocrystal
Self assembly
Superlattice

description: Silicon nanocrystals or quantum dots are non-toxic and exhibit unique size tunable opto-electronic properties. Their bright photoluminescence as well as their ability to generate more than one electron per photon absorbed make them good candidates for both bioimaging and photovoltaics applications. Their surface can be functionalized with different ligands that protect them against oxidation and allow them to be dispersed and stable in a variety of solvents. Dodecane capped silicon nanocrystals can be dispersed in non-polar solvents such as hexane, chloroform or toluene for years without aggregating nor losing their optical properties. When deposited on a substrate under certain conditions, dodecane capped silicon nanocrystals can self-assemble into 2D or 3D periodic arrays of quantum dots called superlattices. These ordered structures of nanocrystals can potentially enhance the conductivity of the nanocrystal thin film which would be helpful for photovoltaic applications. In order to perform charge transport measurements through superlattices, large uniform ordered nanocrystal films must be achieved. Two deposition processes are studied and optimized to lead to the formation of several microns large both 2D and 3D silicon nanocrystals superlattices. A model is developed to understand the superlattice growth mechanism and several parameters are found to influence the superlattice morphology. Silicon nanocrystals can also be functionalized with chromophores to enhance their optical absorption. This can improve efficiencies of self-assembled quantum dots solar devices. Silicon nanocrystals functionalized with pyrene units are studied using transient absorption spectroscopy. They exhibit enhanced optical absorption and efficient carrier multiplication via energy transfer from the pyrene unit to the nanocrystal core. Finally, carboxylate terminated silicon nanocrystals are stable in water over a wide range of pH which makes them suitable for self-assembly in aqueous media. Incorporating biological receptor-substrate sites to the nanocrystal surface can permit recognition-driven self-assembly. Carbodiimide activation is commonly used to biofunctionalize nanoparticles. This chemistry is tested to attach an amine terminated PEG (polyethylene glycol) molecule to silicon nanocrystals. PEG functionalization is found to improve silicon nanocrystal photoluminescence stability.