cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Enhancement of oncolytic herpes simplex type 1 virotherapy
Creators: name: Delwar, Zahid M.
Publisher: name: University of British Columbia
Year: 2018

description: Despite excellent safety data, antitumor efficacy of the oncolytic herpes simplex virus type 1 (oHSV-1) in glioblastoma (GBM) patients is not satisfactory. A major enhancement of the oncolytic activity of the oHSV-1 is necessary to eradicate the GBM in clinics. To enhance the efficacy and tumour specificity, we first developed a GBM specific triple regulated oHSV-1 amplicon system (SU4-124 HSV-1). Translational regulation was achieved by incorporating five copies of microRNA 124 target sequences into the 3’UTR of the ICP4 gene. Additionally, a 5'UTR of rat fibroblast growth factor -2 was added in front of the viral ICP4 gene open reading frame. The SU4-124 HSV-1 demonstrated enhanced tumour specificity and stronger anti-tumour efficacy compared to the tumour non specific CMV- ICP4 HSV-1 in both in-vitro and in-vivo GBM models. We then examined the effect of a potent STAT inhibitor, which is the key regulator of interferon (IFN) response, nifuroxazide (NF), a prescription anti-diarrheal drug, on the oHSV-1 efficacy. This was done with the aim of reinforcing the anti-tumour efficacy of oHSV-1 and developing an effective combination therapy. Here, we found that NF synergistically augments the anti-tumour efficacy of oHSV-1 by regulating the anti-apoptotic properties of HSV-1 in various tumour cells. Moreover, our data demonstrated that STAT1/3 activation mediated the underlying cellular mechanism of this novel combination. To further improve the efficacy of oHSV-1, possible barriers in the microenvironment of GBM need to be identified. Since previous clinical GBM have documented an abundance of microglia /macrophages, we first investigated the interaction of oHSV-1 and microglia/macrophages in in-vitro and in-vivo GBM models. We found evidence that microglia/macrophages suppress oHSV-1 in glioma mass by generating a physical barrier to the dissemination of oHSV-1. We also observed that the deficiencies in viral replication in microglial cells are associated with the STAT1/3-mediated silence of particular viral genes. We found that an oxindole/imidazole derivative, C16, can aid the viral replication in microglia/macrophages and dramatically increase the therapeutic efficacy of oHSV-1 in GBM animal model. In conclusion, this project outlines possible ways to overcome the barriers involved in oHSV-1 therapy to successfully eradicate clinical GBM.
Biodiversity_LTER_EU_IL_015_Butterflies_2016-2019
Creators: name: Segev, Nitzan
Publisher: name: https://b2share.eudat.eu
Year: 2020
Subjects: biodiversity, butterflies

description: Day visual observations using butterfly net/ camera/ binocular, The observations are conducted by a single observer, walking along belt transects,20-30 minutes for each transect. The data collection follows the National Butterfly Monitoring Scheme in Israel (BMS-IL) protocol and using their app.
Semiclassical Regge trajectories of noncritical string and large-N QCD
Creators: name: Makeenko, Yuri
name: Olesen, Poul
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: By properly treating the path integral over the boundary value of the Liouville field (associated with reparametrizations of the boundary contour) in open string theory, we derive consistent off-shell scattering amplitudes in d=26 dimensions. In d<26 we consider a recently proposed boundary ansatz which reproduces a semiclassical correction to the classical string (known as the Luscher term) and obtain in the semiclassical approximation a linear Regge trajectory with the intercept (d-2)/24. We associate it with the quark-antiquark Regge trajectory in large-N QCD and explain why it dominates over perturbative QCD when t > -few GeV^2.
description: 20pp., 2 figures; v2: minor changes, to appear in JHEP
User Design in Archives - the Language and Archives Mentorship Program
Creators: name: Hali Dardar
name: Mary Linn
name: Adrienne Tsikewa
Publisher: name: Zenodo
Year: 2022
Subjects: linguistics
language documentation
user design
language archiving

description: User Design in Archives - the Language and Archives Mentorship Program

Hali Dardar, Mary Linn, Adrienne Tsikewa, Emily Edenshaw-Chafin, Joe Brandt, Shea Sky, Alanna Charles & Jasmine Jimerson

Presented 5 October 2022 at the Berlin-Brandenburg Academy of Sciences and Humanities at the Conference Where Do We Need to Go From Here? - Language Documentation and Archiving,  in the UNESCO International Decade of Indigenous Languages
Hutan Wakaf: Cerita dari Tanah Rencong.pdf
Creators: name: Islamiyah, Nining
Publisher: name: figshare
Year: 2021
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 70504 Forestry Management and Environment
subject: FOS: Agriculture, forestry and fisheries

description: Indonesia termasuk ke dalam salah satu negara yang mempunyai hutan hujan tropis subur di dunia. Potensi ini masih belum dapat dimaksimalkan karena masih terdapat banyak permasalahan. Salah satu permasalahan yaitu deforestasi hutan, sehingga bencana alam dan perubahan iklim di Indonesia rentan terjadi. Akibatnya, ekosistem hutan terganggu dan berdampak pada keseimbangan lingkungan. Permasalahan ini menjadi pemicu munculnya hutan wakaf dari gerakan peduli hutan oleh komunitas hutan tersisa di Aceh. Tujuan adanya hutan wakaf yaitu memperbaiki ekosistem hutan, membantu mata pencaharian penduduk sekitar, meningkatkan tingkat kesejahteraan penduduk setempat dari pengelolaan hutan, dan konservasi hutan sekaligus kegiatan ekowisata berbasis hutan wakaf. Dalam mengembangkan hutan wakaf, peran dari regulator, fasilitator, motivator serta pengawas sangat diperlukan. Hal ini untuk membantu dalam meningkatkan kepedulian segenap masyarakat dalam memajukan hutan wakaf di Indonesia.
Eigenschaften neuer Fullerenmaterialien
Creators: name: Ulas, Seyithan
Publisher: name: Karlsruhe
Year: 2013
Subjects: Fullerenmaterialien
Fullerene
non-IPR Fullerene
Photoelektronenspektroskopie
Metallcluster
UHV-Apparaturen
Reaktivität der Fullerene

description: Eigenschaften neuer Fullerenmaterialien wurden unter Ultra-Hoch-Vakuum-Bedingungen untersucht.
Chiral symmetry in strongly interacting matter
Creators: name: Weise, Wolfram
Publisher: name: arXiv
Year: 2010
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: This is a brief summary of topics that were presented as lectures within the programme "New Frontiers in QCD 2010" at the Yukawa Institute of Theoretical Physics in Kyoto. The basic subject is phases and symmetry breaking patterns as they emerge from the approximate chiral symmetry of QCD. Part I focuses on the QCD interface with nuclear physics via chiral effective field theory. This includes nuclear thermodynamics and, in particular, constraints for compressed and hot baryonic matter provided by the density and temperature dependence of the chiral condensate. Part II explores aspects of the QCD phase diagram using a non-local improved version of the Polyakov - Nambu - Jona-Lasinio (PNJL) model. A prominent feature of such an approach is the occurence of a dynamical entanglement between chiral and deconfinement crossover transitions. Comparisons with available results from lattice QCD thermodynamics will be made.
description: 14 pages, 12 figures, Lectures presented at New Frontiers in QCD, YITP, Kyoto; Suppl. Prog. Theor. Phys., in print
Fractional Quantum Hall States at 1/3 and 5/2 Filling: the Density-Matrix Renormalization Group Calculations
Creators: name: Zhao, Jize
name: Sheng, D. N.
name: Haldane, F. D. M.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: In this paper, the density-matrix renormalization group method is employed to investigate the fractional quantum Hall effect at filling fractions $ν=1/3$ and 5/2. We first present benchmark results at both filling fractions for large system sizes to show the accuracy as well as the capability of the numerical algorithm. Furthermore, we show that by keeping a large number of basis states, one can also obtain accurate entanglement spectrum at $ν=5/2$ for large system with electron number up to $N_e=34$, much larger than systems previously studied. Based on a finite-size scaling analysis, we demonstrate that the entanglement gap defined by Li and Haldane is finite in the thermodynamic limit, which characterizes the topological order of the FQHE state.
description: 6 pages, minor changes
Shifted Riccati Procedure: Application to Conformal Barotropic FRW Cosmologies
Creators: name: Rosu, Haret C.
name: Khmelnytskaya, Kira V.
Publisher: name: arXiv
Year: 2010
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: In the case of barotropic FRW cosmologies, the Hubble parameter in conformal time is the solution of a simple Riccati equation of constant coefficients. We consider these cosmologies in the framework of nonrelativistic supersymmetry that has been effective in the area of supersymmetric quantum mechanics. Recalling that Faraoni [Amer. J. Phys. 67 (1999), 732-734] showed how to reduce the barotropic FRW system of differential equations to simple harmonic oscillator differential equations, we set the latter equations in the supersymmetric approach and divide their solutions into two classes of 'bosonic' (nonsingular) and 'fermionic' (singular) cosmological zero-mode solutions. The fermionic equations can be considered as representing cosmologies of Stephani type, i.e., inhomogeneous and curvature-changing in the conformal time. We next apply the so-called shifted Riccati procedure by introducing a constant additive parameter, denoted by S, in the common Riccati solution of these supersymmetric partner cosmologies. This leads to barotropic Stephani cosmologies with periodic singularities in their spatial curvature indices that we call U and V cosmologies, the first being of bosonic type and the latter of fermionic type. We solve completely these cyclic singular cosmologies at the level of their zero modes showing that an acceptable shift parameter should be purely imaginary, which in turn introduces a parity-time (PT) property of the partner curvature indices.
An Innovative Approach to Teaching Mechanism Using Augmented Reality Technologies
Creators: name: Florin, Girbacia; Silviu, Butnariu
Publisher: name: Editura Universitara
Year: 2012
Subjects: subject: 0 Social sciences
subject: 37 Education
subject: 371 Instructional design
subject: 004:37 Elearning

description: This paper presents a markerless AR book for teaching in enjoyable way mechanisms in mechanical engineering courses. The main idea is to provide to the student real time information on mechanism structure and kinematics by mixing images from the real world with 3D virtual objects. Although the user may watch a physical experiment by means of a webcam, on the computer screen he will see real book pages and, superimposed, the relevant graphical annotations and 3D mechanism simulation. The
A band structure scenario for the giant spin-orbit splitting observed at the Bi/Si(111) interface
Creators: name: Frantzeskakis, Emmanouil
name: Pons, Stephane
name: Grioni, Marco
Publisher: name: arXiv
Year: 2010
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The Bi/Si(111) (sqrt{3} x sqrt{3})R30 trimer phase offers a prime example of a giant spin-orbit splitting of the electronic states at the interface with a semiconducting substrate. We have performed a detailed angle-resolved photoemission (ARPES) study to clarify the complex topology of the hybrid interface bands. The analysis of the ARPES data, guided by a model tight-binding calculation, reveals a previously unexplored mechanism at the origin of the giant spin-orbit splitting, which relies primarily on the underlying band structure. We anticipate that other similar interfaces characterized by trimer structures could also exhibit a large effect.
description: 11 pages, 13 figures
Reinventing Buddhism : conversations and encounters in modern India, 1839 - 1956
Creators: name: Ober, Douglas Fairchild
Publisher: name: University of British Columbia
Year: 2019

description: This dissertation offers a fresh perspective on what has long been called India’s modern Buddhist revival. Theories of this revival are based on the idea that Buddhism, a religion founded in India more than two and a half millennium ago, disappeared between the thirteenth to fourteenth centuries and was reborn in 1956 when the Indian constitutionalist Dr. B.R. Ambedkar converted to Buddhism along with half a million of his Dalit (former ‘untouchable’) followers. This, however, is only part of the story. Taking on the conventional narrative, the study assesses how much was really known about Buddhism in the centuries after its disappearance and asks what sense we can make of the important place that Buddhism came to hold in modern Indian society. Through an extensive examination of disparate materials held at archives and temples across India and South Asia, the study demonstrates the integral role Buddhism played in India in the century prior to Ambedkar’s conversion. To frame the discussion, each chapter of the dissertation highlights an important facet of the dynamic interplay between British colonialism, global circuits of knowledge and local Indian agency. The first four chapters (c. 1830s – 1910) examine the discovery of Buddhist ruins in the subcontinent and the challenges British epistemologies posed to prevailing Indian memories of these spaces; Indian educators and the place of Buddhism in colonial education systems; Buddhism’s public life among new religious movements and literary publics; and the roles that Indians played in the development of global networks and new pilgrimage circuits. The last four chapters (c. 1910 – 1956) turn to Buddhism’s influence among the Hindu right and Indian National Congress; the radical non-Brahmin and Buddhist conversion movements of marginalized communities; the fusion of Buddhist and socialist ideologies in the interwar period; and the dominant public role that the independent Indian state gave to Buddhism in its domestic and foreign policies. The originality of the work rests in its understanding of Buddhism not just as an institutionalized practice and system of thought but as an imagined and inventive ‘place-world’ capable of transforming the very here and now.
On the spin-temperature evolution during the epoch of reionization
Creators: name: Thomas, Rajat M.
name: Zaroubi, Saleem
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Simulations estimating the differential brightness temperature of the redshifted 21-cm from the epoch of reionization (EoR) often assume that the spin temperature is decoupled from the background CMB temperature and is much larger than it. Although a valid assumption towards the latter stages of the reionization process, it does not necessarily hold at the earlier epochs. Violation of this assumption will lead to fluctuations in differential brightness temperature that are neither driven by density fluctuations nor by HII regions. Therefore, it is vital to calculate the spin temperature self-consistently by treating the Lyman-alpha and collisional coupling of spin temperature to the kinetic temperature. In this paper we develop an extension to the BEARS algorithm, originally developed to model reionization history, to include these coupling effects. Here we simulate the effect in ionization and heating for three models in which the reionization is driven by stars, miniqsos or a mixture of both.We also perform a number of statistical tests to quantify the imprint of the self-consistent inclusion of the spin temperature decoupling from the CMB. We find that the evolution of the spin temperature has an impact on the measured signal specially at redshifts higher than 10 and such evolution should be taken into account when one attempts to interpret the observational data.
description: 15 pages, 18 figures, accepted for publication in Monthly Notices of the Royal Astronomical Society
Diffusive Transport Enhanced by Thermal Velocity Fluctuations
Creators: name: Donev, A.
name: de la Fuente, A.
name: Bell, J. B.
name: Garcia, A. L.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study the contribution of advection by thermal velocity fluctuations to the effective diffusion coefficient in a mixture of two indistinguishable fluids. The enhancement of the diffusive transport depends on the system size L and grows as \ln(L/L_0) in quasi two-dimensional systems, while in three dimensions it scales as L_0^{-1}-L^{-1}, where L_0 is a reference length. The predictions of a simple fluctuating hydrodynamics theory are compared to results from particle simulations and a finite-volume solver and excellent agreement is observed. Our results conclusively demonstrate that the nonlinear advective terms need to be retained in the equations of fluctuating hydrodynamics when modeling transport in small-scale finite systems.
description: To appear in Phys. Rev. Lett., 2011
Maintenance of transcription factor networks in mature neurons
Creators: name: Keatings, Kathleen
Publisher: name: University of British Columbia
Year: 2018

description: The lifelong identity and function of a neuron is dictated by the set of effector genes it expresses in its terminally differentiated state. Neuron-specific effector gene expression is established and maintained by networks of transcription factors. How elaborate cascades of transcription factors establish neuronal identities during development has been studied extensively; however, how transcription factor networks are maintained in mature neurons to maintain effector gene expression remains poorly understood. I used the well-characterized transcription factor networks in Drosophila Tv1 and Tv4 neurons to further understand how transcription factor networks are maintained in mature neurons. I focused on the transcription factors Apterous and Dimmed, and investigated the cis- and trans- regulatory transcriptional mechanisms that govern initiation and maintenance of their expression. I previously identified a 756 bp genomic region (dimm.K1) upstream of dimmed that is sufficient to initiate and maintain reporter expression in Tv1 and Tv4 neurons. Here I characterized the trans-regulatory inputs of dimm.K1 reporter expression. I found that different transcriptional inputs are required for initiation vs. maintenance of dimm.K1 reporter expression. Further, inputs required for maintenance differ not only between cell subtypes (Tv1 vs. Tv4) but also between individual cells of the same subtype (Tv1 neurons in thoracic segments 1 and 3). I also compared apterous initiation and maintenance. My previous work had identified a 3.845 kb genomic region (ap.K1) upstream of apterous that is sufficient to initiate, but not maintain, reporter expression in Tv1 and Tv4 neurons. In this thesis I show that the addition of a region with putative TRE activity to the ap.K1 initiation element is sufficient to add maintenance of reporter expression in Tv1 and Tv4 neurons. Overall, I show that a variety of mechanisms can maintain the expression of transcription factors in mature neurons, and that these are different and more varied than the mechanisms of initiation. Furthermore, for any single transcription factor, the initiation mechanisms that are shared by different cell subtypes can diverge into diverse cell-specific maintenance mechanisms.
Topological defect formation from 2PI effective action techniques
Creators: name: Berges, J.
name: Roth, S.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Lattice (hep-lat)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We propose a quantum approach to nonequilibrium dynamics which combines the successful aspects of classical-statistical simulations on a lattice with the ability to take into account quantum corrections. It is based on the 2PI effective action for inhomogeneous fields and a volume average. This procedure does not involve any double counting which could appear in sampling prescriptions for inhomogeneous quantum evolutions. As an example, we study nonequilibrium dynamics of defect formation in 1+1 dimensional relativistic scalar field theory and compare to insufficient descriptions based on homogeneous quantum fields. The latter are analyzed in detail by coupling the field to an external source, such that the emerging influence of defects can be studied by lowering the source to zero.
description: 32 pages, 11 figures
title: Identifying individuals at risk for Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) caused by TMEM43 p. S358L: a genetics educational tool for primary care physicians
Creators: name: Rickert, Lauren
Publisher: name: Memorial University of Newfoundland
Year: 2020

description: Introduction: Newfoundland and Labrador (NL) has an increased incidence of Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is caused by a p.S358L mutation in TMEM43, the first symptom of which may be sudden cardiac death (SCD). When diagnosed and treated, mortality is significantly reduced. Primary care physicians (PCPs) are often the first point of health system contact for families affected by ARVC. PCPs acknowledge the importance of integrating genetics into their practice, but report uncertainty regarding appropriate counseling and referral strategies. Web-based tools can be effective education methods. This project aimed to create a tool designed to increase the likelihood of appropriate management and referral of persons at risk of ARVC caused by p.S358L in TMEM43. Methods: We used a multiple methods, iterative approach to develop an educational tool. This included initial creation, a working lunch with five PCPs, subsequent revision of the tool, use of pre-existing TMEM43 data providing additional family information and then further revision. It was distributed to a cohort of PCPs and Family Medicine Residents (n= 780) for feedback via an online survey containing nine Likert-scale questions, two qualitative questions and five demographic questions. Results: Initial feedback requested greater clarity on whom to refer to appropriate genetic and cardiac services. Pedigree information showed that 56%, 39%, and 31% of affected persons had at least one first-, second-, or third degree relative with a known history of severe cardiac problems at time of their initial presentation. This information was then integrated into the updated version of the tool, to ensure PCPs are prompted to ask about patients family history, including first-, second-, and third-degree relatives. Opinion on the final tool was provided by 43 online surveys completed by PCPs in NL. Overwhelmingly positive responses were noted. Discussion: Feedback from PCPs and multi-generational, historic pedigree information was used to create an educational tool for PCPs which may more easily identify those at risk for ARVC caused by the p. S358L mutation in TMEM43. Future research will evaluate the tool in practice.
On the Scalability of Multidimensional Databases
Creators: name: Szépkúti, István
Publisher: name: arXiv
Year: 2011
Subjects: subject: Databases (cs.DB)
subject: FOS: Computer and information sciences

description: It is commonly accepted in the practice of on-line analytical processing of databases that the multidimensional database organization is less scalable than the relational one. It is easy to see that the size of the multidimensional organization may increase very quickly. For example, if we introduce one additional dimension, then the total number of possible cells will be at least doubled. However, this reasoning does not takethe fact into account that the multidimensional organization can be compressed. There are compression techniques, which can remove all or at least a part of the empty cells from the multidimensional organization, while maintaining a good retrieval performance. Relational databases often use B-tree indices to speed up the access to given rows of tables. It can be proven, under some reasonable assumptions, that the total size of the table and the B-tree index is bigger than a compressed multidimensional representation. This implies that the compressed array results in a smaller database and faster access at the same time. This paper compares several compression techniques and shows when we should and should not apply compressed arrays instead of relational tables.
description: 18 pages, 1 figure, 8 tables. Paper presented at the Second Conference of PhD Students in Computer Science, Szeged, Hungary, 20 - 23 July 2000. For further details, please refer to http://www.inf.u-szeged.hu/~szepkuti/papers.html#scalability
SOME ASPECTS OF AGE-RELATED MACULAR DEGENERATION
Creators: name: Gazizova, L.K.
name: Ermatova, B.O.
Publisher: name: Zenodo
Year: 2023

description: Age-related macular degeneration (AMD) is a common eye disease that leads to a significant decrease in vision and threatens with disability. According to official data from the WHO Center for the Prevention of Avoidable Blindness, the prevalence of this pathology is 300 per 100,000 people. The disease occurs in 40% of cases among people over 40 years old, in 58-100% - over 60 years old.
Novel Nuclear Structure Aspects of the Neutrinoless Double Beta Decay
Creators: name: Menendez, J.
name: Poves, A.
name: Caurier, E.
name: Nowacki, F.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We explore the influence of the deformation on the nuclear matrix elements of the neutrinoless double beta decay (NME), concluding that the difference in deformation -or more generally in the amount of quadrupole correlations- between parent and grand daughter nuclei quenches strongly the decay. We correlate these differences with the seniority structure of the nuclear wave functions. In this context, we examine the present discrepancies between the NME's obtained in the framework of the Interacting Shell Model and the Quasiparticle RPA. We surmise that part of the discrepancy can be due to the limitations of the spherical QRPA in treating nuclei which have strong quadrupole correlations. We surmise that the NME's in a basis of generalized seniority are approximately model independent, i. e. they are "universal".
description: Proceedings of the 10th International Spring Seminar On Nuclear Physics, New Quests In Nuclear Structure, Vietri Sul Mare, May 21-25, 2010 (references added)
Tracing light propagation to the intrinsic accuracy of space-time geometry
Creators: name: Crosta, Mariateresa
Publisher: name: arXiv
Year: 2010
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Mathematical Physics (math-ph)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: Advancement in astronomical observations and technical instrumentation requires coding light propagation at high level of precision; this could open a new detection window of many subtle relativistic effects suffered by light while it is propagating and entangled in the physical measurements. Light propagation and its subsequent detection should indeed be conceived in a fully relativistic context, in order to interpret the results of the observations in accordance with the geometrical environment affecting light propagation itself, as an unicum surrounding universe. One of the most intriguing aspects is the boost towards the development of highly accurate models able to recon- struct the light path consistently with General Relativity and the precepts of measurements. This paper deals with the complexity of such a topic by showing how the geometrical framework of models like RAMOD, initially developed for astrometric observations, constitutes an appropriate physical environment for back tracing a light ray conforming to the intrinsic accuracy of space-time. This article discusses the reasons why RAMOD stands out among the existent approaches applied to the light propagation problem and provides a proof of its capability in recasting recent literature cases.
description: 15 pages, 5 figures. Revised version, references and appendixes added. PRD re-submitted
Guidelines and good practices for the use of DocTalent4EU credentials connected to ESCO
Creators: name: Pêgo, João Pedro
name: Freitas, Ana
Publisher: name: DocTalent4EU Consortium
Year: 2025
Subjects: Digital credentials
Doctoral education
Skills recognition
Higher Education

description: The document provides clear, hands-on guidance for Higher Education Institutions aiming to adopt DocTalent4EU digital credentials. Aligned with the ESCO framework and issued via the Europass Digital Credentials Infrastructure, these credentials formally recognise key transferable skills gained by PhD candidates, specifically in communication, teamwork, and leadership.

Drawing on successful pilot implementations, the document offers good practices, technical manuals, and tutorials to support institutions in integrating digital credentialing into their processes with minimal technical investment. The approach promotes greater visibility and recognition of doctoral-level skills, enhancing employability and institutional innovation in line with European priorities.

DocTalent4EU is a HORIZON EUROPE funded project which aims to enhance PhD employability through a strong, visible and innovative recognition-system of the most in-demand transferable skills that early-career researchers acquire or will acquire through their doctoral training and research activities.
Chaotic inflation and supersymmetry breaking
Creators: name: Kallosh, Renata
name: Linde, Andrei
name: Olive, Keith A.
name: Rube, Tomas
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We investigate the recently proposed class of chaotic inflation models in supergravity with an arbitrary inflaton potential. These models are extended to include matter fields in the visible sector and we employ a mechanism of SUSY breaking based on a particular phenomenological version of the KKLT mechanism (the KL model). We describe specific features of reheating in this class of models and show how one can solve the cosmological moduli and gravitino problems in this context.
description: 12 pages, 3 figures
Design of quantum dot and smartphone-based luminescent bioassay platforms for prospective point-of-care diagnostics
Creators: name: Petryayeva, Eleonora
Publisher: name: University of British Columbia
Year: 2017

description: Smartphones are essential components of daily life. These devices feature built-in cameras and light sources, data storage, and wireless data transmission, making them emerging devices for optical imaging and diagnostic bioassays. To date, the majority of smartphone-based diagnostics have been developed for colourimetric assays, which often suffer from limited multiplexing capability and poor sensitivity. In general, fluorescence-based assays offer greater sensitivity and multiplexing capacity, and in combination with smartphone platform may help to overcome these limitations. This thesis describes research toward the development of smartphone platforms for fluorescence-based bioassays using quantum dots (QDs) and Förster resonance energy transfer (FRET), and addresses two critical challenges: multiplexing and analysis of biological sample matrices. Multiplexing was achieved by matching the built-in RGB (red-green-blue) channels of smartphone cameras with the narrow, bright, and tunable emission of QDs. The QDs provided superior brightness in comparison to traditional fluorescent dyes and proteins, and served as excellent FRET donors in assays that used proteases as model analytes. Up to threeplex assays were demonstrated for the detection of trypsin, chymotrypsin, and enterokinase. The analytical performance of the smartphone-based platform matched that of a bench-top spectrofluorimeter, where the smartphone was a fraction of the cost and size. A smartphone based platform was also developed for detection of analytes in serum and whole blood. Most clinical samples will take this form and necessitate careful assay design to overcome challenges associated with physical, optical and chemical properties of whole blood. Blood is strongly absorbing, scattering, autofluorescent, and contains high concentrations of proteins and small molecules. A well-thought-out combination of QDs, FRET, and a paper-in-PDMS chip enabled direct, single-step and quantitative fluorescence-based detection of thrombin activity in whole blood. The research in this thesis is a foundation for the development of novel point-of-care diagnostics assays with consumer electronics that could help enable personalized health care.
Asymmetry of bipartite quantum discord
Creators: name: Fel'dman, E. B.
name: Zenchuk, A. I.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: It is known from the analysis of the density matrix for bipartite systems that the quantum discord (as a measure of quantum correlations) depends on the particular subsystem chosen for the projective measurements. We study asymmetry of the discord in a simple physical model of two spin-1/2 particles with the dipole-dipole interaction governed by the XY Hamiltonian in the inhomogeneous magnetic field. The dependence of the above discord asymmetry on the Larmour frequencies at both T=0 (the ground state) and $T>0$ has been investigated. It is demonstrated, in particular, that the asymmetry is negligible for high temperatures but it may become significant with the decrease in temperature.
description: 5 pages 3 figures
Intertwining operators for Sklyanin algebra and elliptic hypergeometric series
Creators: name: Zabrodin, A.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mathematical Physics (math-ph)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences

description: Intertwining operators for infinite-dimensional representations of the Sklyanin algebra with spins l and -l-1 are constructed using the technique of intertwining vectors for elliptic L-operator. They are expressed in terms of elliptic hypergeometric series with operator argument. The intertwining operators obtained (W-operators) serve as building blocks for the elliptic R-matrix which intertwines tensor product of two L-operators taken in infinite-dimensional representations of the Sklyanin algebra with arbitrary spin. The Yang-Baxter equation for this R-matrix follows from simpler equations of the star-triangle type for the W-operators. A natural graphic representation of the objects and equations involved in the construction is used.
description: 33 pages, 11 figures, minor changes, references added
Implications of the recent measurement of pure annihilation $B_s \to π^+ π^-$ decays in QCD factorization
Creators: name: Zhu, Guohuai
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The CDF 3.7 sigma evidence of pure annihilation $B_s \to π^+ π^-$ decays, if confirmed, would imply a large annihilation scenario in the QCD factorization approach. This is somewhat unexpected as the large annihilation scenario was disfavored in previous studies. In this paper we reinvestigate the role of annihilation topology in QCD factorization. We find that it is not easy to reach the CDF central value of $B_s \to π^+ π^-$ decays when other decay channels are considered. Our analysis also reveals that, for well-measured charmless B decays into two final pseudoscalar mesons, the QCD factorization predictions with large annihilation parameters show good agreement with the experimental data except $B_s \to K^+ K^-$ and $B_d \to K^0 \bar{K}^0$ decays. Though other possibilities can not be excluded, this may indicate that the SU(3) flavor symmetry breaking should be taken into account for the annihilation topology. In addition, there are different annihilation topologies, so that somewhat different annihilation parameters may be chosen for different final states and different annihilation topologies. If so, the predictive power of the QCD factorization method may be rather limited for many decay channels.
description: 11 pages, 3 figures, accepted for publication in Phys. Lett. B
title: Representations and Experiences of Place: The Islands of Sheppey in the late medieval and early modern period
Creators: name: Caiazza, Melanie Grace
Publisher: name: University of Kent
Year: 2022

description: Places were important physical and cultural spaces in the late medieval and early modem period. This thesis examines the diversity, complexity and evolution of making meaning in relation to specific places, land and dwellings, within a small island community in northeast Kent known as the Islands of Sheppey, Harty and Elmley. The method used was thematic; with each chapter presenting a case for the understanding of places as physically and culturally complex spaces. Chapter I provides a context for localised study in relation to wider research which has focused on the study of island settlements, landscape and cultural history. Chapter 2 introduces a theoretical framework for visual and textual conceptualisations of landscape spaces whilst also introducing how biographical writings, such as the last will and tcstamen4 imaginatively narrate landscape spaces on the islands. Chapter 3 presents a chronological history of the evolving physical landscape into specific social settlements on the islands. Chapter 4 examines how the relationship between religious places, such as the Minster on Sheppey, shaped local religious practices unique to the island, such as burial at the Minster church and naming of daughters after local Anglo-Saxon women saints. The changes and continuities in beliefs and practices were intrinsically linked to the physical and local landscape. Chapter 5 examines estate maps of the islands; visually exploitive spatial perspectives commissioned by the Crown and wealthy landholders whilst Chapter 6 investigates indigenous textual mappings of the islands, specifically the last will and testament. Chapters 7 and 8 examine the relationship between inheritance strategies and locally adapted descriptions of places, with particular reference to the role of the family as integral to place description, remembrance and inheritance. It is suggested, by the collective and cumulative nature of all eight chapters, that medieval and early modem island studies are an important contribution to national religious and social history.
The multiple quantum NMR dynamics in systems of equivalent spins with the dipolar ordered initial state
Creators: name: Doronin, S. I.
name: Fel'dman, E. B.
name: Zenchuk, A. I.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The multiple quantum (MQ) NMR dynamics in the system of equivalent spins with the dipolar ordered initial state is considered. The high symmetry of the MQ Hamiltonian is used in order to develop the analytical and numerical methods for an investigation of the MQ NMR dynamics in the systems consisting of hundreds of spins from "the first principles". We obtain the dependence of the intensities of the MQ NMR coherences on their orders (profiles of the MQ NMR coherences) for the systems of $200 - 600$ spins. It is shown that these profiles may be well approximated by the exponential distribution functions. We also compare the MQ NMR dynamics in the systems of equivalent spins having two different initial states, namely the dipolar ordered state and the thermal equilibrium state in the strong external magnetic field.
description: 11 pages 4 figures
Spin dynamics in the pressure-induced two-leg ladder cuprate superconductor Sr$_{14-x}$Ca$_{x}$Cu$_{24}$O$_{41}$
Creators: name: Qin, Jihong
name: Lan, Yu
name: Feng, Shiping
Publisher: name: arXiv
Year: 2011
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Within the two-leg $t$-J ladder, the spin dynamics of the pressure-induced two-leg ladder cuprate superconductor Sr$_{14-x}$Ca$_{x}$Cu$_{24}$O$_{41}$ is studied based on the kinetic energy driven superconducting mechanism. It is shown that in the pressure-induced superconducting state, the incommensurate spin correlation appears in the underpressure regime, while the commensurate spin fluctuation emerges in the optimal pressure and overpressure regimes. In particular, the spin-lattice relaxation time is dominated by a temperature linear dependence term at low temperature followed by a peak developed below the superconducting transition temperature, in qualitative agreement with the experimental observation on Sr$_{14-x}$Ca$_{x}$Cu$_{24}$O$_{41}$.
description: 8 pages, 5 figures, accepted for publication in Journal of Physics: Condensed Matter
»Gerecht und Sünder zugleich«
Creators: name: Oberdorfer, Bernd
Publisher: name: Cursor_ Zeitschrift für explorative Theologie
Year: 2021

description: Luthers entscheidende reformatorische Einsicht war, dass unsere Identität nicht in dem gründet, was wir selbst tun oder nicht tun. Sie gründet auch nicht in unserem Urteil über uns selbst. Sie gründet vielmehr in dem, was Gott in uns sieht.
description: Cursor_ Zeitschrift für explorative Theologie, Nr. 2 (2019): Identität
Grade twelve students establishing the relationship between differential and integral calculus using graphs
Creators: name: ., Kinley
Publisher: name: figshare
Year: 2022
Subjects: subject: 10203 Calculus of Variations, Systems Theory and Control Theory
subject: FOS: Mathematics
subject: 130303 Education Assessment and Evaluation
subject: FOS: Educational sciences
subject: 139999 Education not elsewhere classified
subject: 130306 Educational Technology and Computing

description: Calculus is an important subject for science, engineering, and other fields of studies but phenomenally it is abstract and difficult to learn. Despite its importance, the teaching of introductory calculus always emphasizes manipulation of algebraic notations and rote learning. Most students learn the how instead of the why of calculus due to extensive use of algebraic symbols and notations. Therefore, graphing activities were developed based on the learning cycle approach and the lesson was taught for an hour in the classroom. This study investigates the effectiveness of the lesson in understanding the relationship between differentiation and integration calculus and to measure the students’ attitude towards the learning unit. Sixty-five grade twelve students from higher secondary school were selected for the study. The test scores showed that there was significance improvement in the post?test scores compared to the pre-test scores. It was also found that the lesson was effective and enriching.
Random field Ising model : statistical properties of low-energy excitations and of equilibrium avalanches
Creators: name: Monthus, Cecile
name: Garel, Thomas
Publisher: name: arXiv
Year: 2011
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: With respect to usual thermal ferromagnetic transitions, the zero-temperature finite-disorder critical point of the Random-field Ising model (RFIM) has the peculiarity to involve some 'droplet' exponent $θ$ that enters the generalized hyperscaling relation $2-α= ν(d-θ)$. In the present paper, to better understand the meaning of this droplet exponent $θ$ beyond its role in the thermodynamics, we discuss the statistics of low-energy excitations generated by an imposed single spin-flip with respect to the ground state, as well as the statistics of equilibrium avalanches i.e. the magnetization jumps that occur in the sequence of ground-states as a function of the external magnetic field. The droplet scaling theory predicts that the distribution $dl/l^{1+θ}$ of the linear-size $l$ of low-energy excitations transforms into the distribution $ds/s^{1+{θ/d_f}}$ for the size $s$ (number of spins) of excitations of fractal dimension $d_f$ ($s \sim l^{d_f}$). In the non-mean-field region $dd_c$, droplets have a fractal dimension $d_f=2 θ$ leading to the well-known mean-field result $ds/s^{3/2}$. Zero-field equilibrium avalanches are expected to display the same distribution $ds/s^{1+{θ/d_f}}$. We also discuss the statistics of equilibrium avalanches integrated over the external field and finite-size behaviors. These expectations are checked numerically for the Dyson hierarchical version of the RFIM, where the droplet exponent $θ(σ)$ can be varied as a function of the effective long-range interaction $J(r) \sim 1/r^{d+σ}$ in $d=1$.
description: 24 pages, 15 figures, v2=final version
Der »Name«
Creators: name: Faerber, Walter
Publisher: name: Cursor_ Zeitschrift für explorative Theologie
Year: 2021

description: Der biblische Gedanke, der dem Begriff der Identität am nächsten steht, ist der »Name«. Aber dabei zeigen sich Ähnlichkeiten und Unterschiede. Am wichtigsten: den eigenen Namen bekommt man zugesprochen. Man sucht ihn sich nicht aus. Und wenn man es doch versucht, geht es schief.
description: Cursor_ Zeitschrift für explorative Theologie, Nr. 2 (2019): Identität
Smad2 overexpression rescues the tgf-β3 null mutant mice cleft palate by increased apoptosis
Creators: name: Almegbel, Abdullah M.
Publisher: name: University of British Columbia
Year: 2017

description: Objectives: Cleft lip/palate is a common birth defect. It occurs in about one in 700 live births worldwide. In non-syndromic cleft lip/palate, a linkage to TGF-β3 has been shown. Signaling of TGF-β3 is mediated in the cell through the Smad2 protein. During secondary palate fusion TGF-β3 signaling leads to the disappearance of the epithelial midline seam and the confluence of the palatal mesenchyme. TGF-β3 null mice are born with a cleft in the secondary palate, a phenotype that has been rescued by targeted overexpression of Smad2 in the MEE. The goal of this research was to understand the mechanism of palatal fusion in the rescue mice. Methods: The heads of embryos of four different mice models (wild-type, rescue, K14-Smad2 overexpression and TGF-β3 null) were collected at gestational age E14.5 genotyped, fixed and embedded in paraffin. Serial sections were studied for detection of apoptosis and epithelial mesenchymal transition using immunofluorescence. Images were captured with confocal laser microscopy. Results: TGF-β3 null mice developed a cleft in the secondary palate while mice that had both the TGF-β3 null and overexpression K14-Smad2 genotypes had fusion of the secondary palate. The medial edge epithelium of the rescue mice had a much higher ratio of cells with cleaved caspase (31.7% anterior, 33% middle and 35.6% posterior), than in the wild-type mice (0.0% anterior, 5.31% middle and 0.0% posterior). The K14-Smad2 overexpression genotype mice had an increased number of apoptosis positive MEE when compared to the wild-type mice (13.7% anterior, 10.1% middle and 17.6% posterior). The increase in apoptosis was correlated with increased p-Smad2 in the MEE. Conclusions: Smad2 overexpression may have rescued the cleft in the secondary palate by increasing apoptosis in the medial edge epithelium. Thus, the mechanism of rescue is not identical to the events that occur normally during palatal fusion.