cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Codebooks SHARENEWS
Creators: name: D.C. Trilling
name: Kulshrestha, Juhi
name: Vreese, Claes De
name: Halagiera, Denis
name: Jakubowski, Jakub
name: Möller, Judith
name: Puschmann, Cornelius
name: Stępińska, Agnieszka
name: Stier, Sebastian
name: Vaccari, Cristian
Publisher: name: University of Amsterdam / Amsterdam University of Applied Sciences
Year: 2020
Subjects: subject: 20 Language, Communication and Culture
subject: Social Science

description: Codebook for annotation of domains and articles to determine the shareworthiness of news-related URLs (SHARENEWS project)
UBA builds answers
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2017
Subjects: subject: Plusenergiehaus
subject: Umweltgerechtes Bauen
subject: Positive energy building
subject: building project
subject: sustainable building
subject: The UBA

description: With this flyer, we want to present you some interesting facts and figures about our building project: a positive energy building in Dessau. For example the key project data, the architectural and the energy concept, the construction materials, the landscaping and the Percent for Art.
Open Science Toolbox for Animal Research
Creators: name: Diederich, Kai
name: Schmitt, Kathrin
name: Schwedhelm, Philipp
name: Bert, Bettina
name: Heinl, Céline
Publisher: name: Forschungzentrum Jülich
Year: 2022
Subjects: open science
animal research
biomedical research

description: doi:10.5281/ZENODO.7032128
description: Open science has become a buzzword in the scientific community that too often misses the practical application for individual researchers. Transparent sharing of research results maximizes their utility and accelerate scientific progress. Open science practices support collaborations and improve communication between science and society. The Open Science Toolbox for Animal Research was created by the Bf3R to provide an overview of open science tools that can be applied throughout the research process, from designing and conducting experiments to analyzing data and publishing results. The tools listed in the table were selected based on their relevance to the animal research community in terms of their intended function to improve transparency and reproducibility. Inclusion of a tool does not imply endorsement by Bf3R, and exclusion of a tool is based solely on relevance; no assessments of tool quality were made or considered in the development of the Open Science Toolbox. We will follow the future developments of open science tools that are suitable for animal research and regularly update this toolbox. If you wish to suggest additional tools that should be added to the list, please email us at: OS-toolbox@bfr.bund.de .
Nasution: total people's resistance and organicist thinking in Indonesia
Creators: name: Turner, Barry J.
Publisher: name: Swinburne
Year: 2024

description: This thesis argues that General Abdul Haris Nasution, the most influential military strategist that Indonesia has produced, developed an elective affinity between his strategies for 'people's resistance' and an organicist vision of the proper relations between the state (including the military) and society that led to the Indonesian Army's formulation of a unique, pervasive and highly durable means of military intervention in politics, the economy and society. Organicism is a stream of political thinking that views state and society as a single organic unity. Corporatist / functional modes of interest representation are often associated with organicist thinking. Nasution's 'people's resistance' strategies emerged during the armed struggle for national independence (from the Dutch) in the second half of the 1940s. The thesis argues that unlike the 'people's war' strategies that emanated from the political left at roughly the same time, Nasution's concepts were designed to uphold organic 'traditional' authority structures and depoliticise the national struggle. Associated with these strategies was a system of territorial commands that shadowed and supervised the aristocratically led civilian administration. The form of military intervention that grew out of this elective affinity reached its peak during the New Order regime of former President Suharto (1966-1998), when the army used its 'people's resistance' doctrines and their associated territorial commands to control the population and the regime championed state-sanctioned corporatist / functional modes of interest representation. The identification of this elective affinity is a major point of departure from previous political biographies of Nasution. Another is the emphasis placed on Nasution's family and personal life, particularly in the early chapters. This thesis explains how personal and family influences encouraged Nasution towards organicist thinking. It identifies how, in the early 1950s, Nasution idealised his 'people's resistance' strategies and the support given to him during the armed struggle by organic 'traditional' authority figures. It shows how Nasution's elective affinity between organicist thinking and 'people's resistance' infused the interventionist doctrines that the army began to develop in the mid-to-late 1950s. In recent years the Indonesian Army has distanced itself from corporatist / functional forms of interest representation and has largely retreated from an active involvement in politics. Nevertheless, the thesis identifies a continuing adherence within the Army leadership to Nasution's system of territorial commands and concepts of 'people's resistance' that cannot readily be reconciled with democratic processes.
Design and implementation of signaling and traffic control for AAPN
Creators: name: Deng, Yong
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Engineering, Electronics and Electrical.

description: Although all-photonic network is a hot topic in recent years, most networks still do not have the ability to achieve high utilization and to allocate bandwidth dynamically and efficiently to an edge node. Many theoretical works and publications have been done in this field. However, up to now there is no commercial or lab product in this area. AAPN (Agile All-Photonic Network) is one research project focusing on these issues while at the same time avoid blocking and starvation. We designed and implemented the whole AAPN signaling protocols under Linux and produced a lab prototype under the AAPN framework. To the best of our knowledge, this is the first AAPN prototype in the world. While bandwidth has increased so much after the Internet first came to reality, user's request increases even much faster. Congestion can not be avoided if there is no algorithm to control it. The XCP (eXplicit Control Protocol) algorithm is a promising congestion control method that uses explicit feedback. However, XCP does not work when the link capacity changes with time. In this research we designed a modified version, the XCP-CL (XCP of Cross-Layer design) algorithm, that works successfully on the AAPN network. Extensive simulation results have verified that XCP-CL has a much better performance compared to the original XCP algorithm.
Understanding leadership's role in inclusive, culturally-appropriate recreation programming in K'atlodeeche First NationHay River Reserve and the town of Hay River, Northwest Territories
Creators: name: Rousell, Davina
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Native American Studies.
subject: Recreation.

description: This thesis employs Foucaultian and postcolonial theories to identify, discuss, and trouble discourses surrounding leadership styles in two communities in the Northwest Territories: the Town of Hay River and the nearby community of K'atlodeeche First Nation/Hay River Reserve. The thesis is composed of two papers. The first paper analyzes the tendency of lifeguards at the Hay River swimming pool to embody an authoritarian leadership style. Further, this paper discusses how an authoritarian leadership style can foster an unwelcoming environment for Aboriginal patrons. The second paper looks at Dene women's leadership in K'atlodeeche First Nation/Hay River Reserve's Summer Day Camp and discusses its impact on one particular Eurocanadian leader. Both papers shed light on the necessity for southern-based, Euro-Canadian recreation leaders to understand Aboriginal communities' practices and norms surrounding culturally appropriate ways of leading in order to plan and implement effective and inclusive programming.
The randomization-induced risk of a trial failing to attain its target power: assessment and mitigation
Creators: name: Wong, Hubert
name: Ouyang, Yongdong
name: Karim, Mohammad Ehsanul
Publisher: name: BioMed Central
Year: 2019

description: Health researchers are familiar with the concept of trial power, a number that prior to the start of a trial is intended to describe the probability that the results of the trial will correctly conclude that the intervention has an effect. Trial power, as calculated using standard software, is an expected power that arises from averaging hypothetical trial results over all possible treatment allocations that could be generated by the randomization algorithm. However, in the trial that ultimately is conducted, only one treatment allocation will occur, and the corresponding attained power (conditional on the allocation that occurred) is not guaranteed to be equal to the expected power and may be substantially lower. We provide examples illustrating this issue, discuss some circumstances when this issue is a concern, define and advocate the examination of the pre-randomization power distribution for evaluating the risk of obtaining unacceptably low attained power, and suggest the use of randomization restrictions to reduce this risk. In trials that randomize only a modest number of units, we recommend that trial designers evaluate the risk of getting low attained power and, if warranted, modify the randomization algorithm to reduce this risk.
Analyzing the impact of process change operations on time-aware processes
Creators: name: Lanz, Andreas
name: Reichert, Manfred
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: Dynamic process change
subject: Process flexibility
subject: Process-aware information system
subject: Temporal constraints
subject: Temporal perspective
subject: Time-aware processes
subject: DDC 004 / Data processing & computer science
subject: Theory of constraints (Management)
subject: Prozessmanagement
subject: Prozessoptimierung

description: The proper handling of temporal process constraints is crucial in many application domains. Contemporary process-aware information systems (PAIS), however, lack a sophisticated support of time-aware processes. As a particular challenge, the enactment of time-aware processes needs to be flexible as time can neither be slowed down nor stopped. Hence, it should be possible to dynamically adapt time-aware process instances to cope with unforeseen events. In turn, when applying such dynamic changes, it must be re-ensured that the resulting process instances are temporally consistent; i.e., they still can be completed without violating any of their temporal constraints. This paper extends existing process change operations, which ensure soundness of the resulting processes, with temporal constraints. In particular, it provides pre- and post-conditions for these operations that guarantee for the temporal consistency of the changed process instances. Further, we analyze the effects a change has on the temporal properties of a process instance. In this context, we provide a means to significantly reduce the complexity when applying multiple change operations. The presented change operations have been prototypically implemented in the AristaFlow BPM Suite.
Breaking probabilities for dominant surface waves on water of finite constant depth
Creators: name: Babanin, Alexander
name: Young, Ian R.
name: Banner, Michael L.
Publisher: name: Swinburne
Year: 2024

description: This paper extends our previous study of the breaking probability of dominant deep water gravity surface waves into the finite water depth environment. It Research reports a unified behavior of the mean breaking statistics once the effects of finite water depth are taken into account. The shallow water wave data that form the basis of this study were acquired at a field experiment site at Lake George, New South Wales, Australia. The breaking events were detected through visual observation of videotaped records of the wave field in combination with acoustic signatures of the breaking waves from a collocated hydrophone. Following Banner et al. [2000], we argue that when constant finite depth bottom influence is operative, nonlinear hydrodynamical effects associated with energy and momentum fluxes within deforming wave groups remain the primary determinant of breaking onset. This underpins our proposed finite depth water parameterization for the environmental dependence of dominant wave breaking probability, given by the average number of breakers passing a fixed point per dominant wave period. The additional influence of bottom interaction with the wind drift current shear and wind forcing are also included in our finite constant depth formulation. This is a natural extension of our recently proposed deep water dependence and reduces to it as the significant wave height becomes much smaller than the water depth. In common with the deep water case we propose that there exists a threshold of the significant peak steepness below which negligible dominant wave breaking occurs. The available data show encouraging agreement with our proposed dependence, with a correlation coefficient approaching 0.9.
Metabolism of ethyl alcohol in rats exposed to cold environment.
Creators: name: Platonow, Nicolas.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1967
Subjects: subject: Biology, Animal Physiology.

description: The study of the metabolism of ethyl alcohol in rats expoxsed to a cold environment was investigated by means of uniformly 14C-labeled ethyl alcohol. In rats exposed to cold for five days, the rate of metabolism of alcohol was accelerated, in contrast to their controls kept at room temperature. Moreover, the rate of absorption of alcohol from the site of its administration and the rate of its removal from the blood was greater in cold-exposed animals than in rats maintained at room temperature. The observed increase in the rate of metabolism of alcohol in cold-exposed rats, however, was not proportional to the rate of increase in the general metabolism. In cold-acclimated rats, whether or not pre-treated with alcohol, cold exposure resulted in an increased rate of alcohol metabolism. In cold-acclimated alcohol pre-treated rats, the increase in the rate of alcohol metabolism was proportional to the increase in overall metabolism. The data also indicate that the rate of alcohol metabolism is essentially independent when given in various doses. However, a dose dependence on the ratio of oxidation of alcohol to the total foodstuff utilization was demonstrated. No detectable changes in the alcohol oxidation rate were caused by partial hepatectomy. A single dose of an adrenergic blocking agent, phenoxybenzamine, immediately prior to the introduction of alcohol, produced a decrease in the oxidation rate of alcohol in rats exposed to cold. This reduction was more pronounced when cold-exposed rats were pre-treated with phenoxybenzamine from the onset of cold exposure, i.e. for five days prior to alcohol administration. The positive influence of the thyroid gland on the metabolic rate of alcohol in animals exposed to cold was demonstrated by blocking hormone production with potassium perchlorate during the cold conditioning period.
Star-forming, rotating spheroidal galaxies in the GAMA and SAMI surveys
Creators: name: Moffett, Amanda J.
name: Phillipps, Steven
name: Robotham, Aaron S. G.
name: Driver, Simon P.
name: Bremer, Malcolm N.
name: Cortese, Luca
name: Wong, O. Ivy
name: Brough, Sarah
name: Brown, Michael J. I.
name: Bryant, Julia J.
name: Conselice, Christopher J.
name: Croom, Scott M.
name: George, Koshy
name: Goldstein, Greg
name: Goodwin, Michael
name: Holwerda, Benne W.
name: Hopkins, Andrew M.
name: Konstantopoulos, Iraklis S.
name: Lawrence, Jon S.
name: Lorente, Nuria P. F.
name: Medling, Anne M.
name: Owers, Matt S.
name: Pimbblet, Kevin A.
name: Richards, Samuel N.
name: Sweet, Sarah
name: van de Sande, Jesse
Publisher: name: Swinburne
Year: 2024

description: The Galaxy And Mass Assembly (GAMA) survey has morphologically identified a class of 'Little Blue Spheroid' (LBS) galaxies whose relationship to other classes of galaxies we now examine in detail. Considering a sample of 868 LBSs, we find that such galaxies display similar but not identical colours, specific star formation rates, stellar population ages, massto-light ratios, and metallicities to Sd-Irr galaxies. We also find that LBSs typically occupy environments of even lower density than those of Sd-Irr galaxies, where similar to 65 per cent of LBS galaxies live in isolation. Using deep, high-resolution imaging from VST KiDS and the new Bayesian, 2D galaxy profile modelling code PROFIT, we further examine the detailed structure of LBSs and find that their S ' ersic indices, sizes, and axial ratios are compatible with those of low-mass elliptical galaxies. We then examine SAMI Galaxy survey integral field emission line kinematics for a subset of 62 LBSs and find that the majority (42) of these galaxies display ordered rotation with the remainder displaying disturbed/non-ordered dynamics. Finally, we consider potential evolutionary scenarios for a population with this unusual combination of properties, concluding that LBSs are likely formed by a mixture of merger and accretion processes still recently active in low-redshift dwarf populations. We also infer that if LBS-like galaxies were subjected to quenching in a rich environment, they would plausibly resemble cluster dwarf ellipticals.
Wieviel Klimaschutz steckt in der 1. Säule der GAP? - Analyse und politische Empfehlungen
Creators: name: Scheffler, Margarethe
name: Wiegmann, Kirsten
name: Lakner, Sebastian
Publisher: name: Umweltbundesamt
Year: 2022
Subjects: subject: Landwirtschaft
subject: Klimaschutz
subject: Treibhauseffekt-Potenzial
subject: Gemeinsame Europäische Agrarpolitik
subject: Öko-Regelungen
subject: Konditionalität
subject: Klimawirksamkeit
subject: Rio-Marker-Methode
subject: Nationaler Strategieplan
subject: Agrarumwelt- und Klimamaßnahmen
subject: 1. Säule
subject: Landwirtschaft

description: Das Policy Paper im Auftrag des Umweltbundesamtes untersucht die Frage, mit welchem zusätzlichen THG-Einsparpotenzial durch die Maßnahmen der 1. Säule (GLÖZ-Standards und Öko-Regelungen) der Gemeinsamen Europäischen Agrarpolitik 2023-2027 zu rechnen ist. Die Ergebnisse basieren auf einer Studie, die im ersten Halbjahr 2022 veröffentlicht wird. Die EU-Kommission hat das Ziel gesetzt, dass 40 % der GAP-Gelder zu Klimazielen beitragen sollen. In diesem Kurzpapier wird am Beispiel der Öko-Regelungen untersucht, ob und in welchem Ausmaß die GAP-Gelder tatsächlich klimawirksam sind. Quelle: www.umweltbundesamt.de
description: This policy paper commissioned by the German Federal Environment Agency examines the greenhouse gas reduction potential from the measures of the first pillar (GAEC standards and eco-schemes) of the Common European Agricultural Policy 2023-2027. The results are based on a study that will be published in the first half of 2022. Quelle: www.umweltbundesamt.de
description: Das Policy Paper im Auftrag des Umweltbundesamtes untersucht die Frage, mit welchem zusätzlichen THG-Einsparpotenzial durch die Maßnahmen der 1. Säule (GLÖZ-Standards und Öko-Regelungen) der Gemeinsamen Europäischen Agrarpolitik 2023-2027 zu rechnen ist. Die Ergebnisse basieren auf einer Studie, die im ersten Halbjahr 2022 veröffentlicht wird. Die EU-Kommission hat das Ziel gesetzt, dass 40 % der GAP-Gelder zu Klimazielen beitragen sollen. In diesem Kurzpapier wird am Beispiel der Öko-Regelungen untersucht, ob und in welchem Ausmaß die GAP-Gelder tatsächlich klimawirksam sind.Mehr zum GAP-Strategieplan finden Sie hier.
Increased immune activation by pathologic α‐synuclein in parkinson's disease
Creators: name: Hoffmeister, Meike
name: Madiona, Karine
name: Behrends, Christian
name: Melki, Ronald
name: Grozdanov, Veselin D.
name: Bousset, Luc
name: Bliederhäuser, Corinna
name: Meier, Christoph
name: Pieri, Laura
name: Kiechle, Martin
name: McLean, Pamela J.
name: Kassubek, Jan Rainer
name: Ludolph, Albert C.
name: Weishaupt, Jochen H.
name: Danzer, Karin
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: DDC 610 / Medicine & health
subject: Parkinson disease; Immunology
subject: Parkinson disease; Metabolism
subject: Cytokines; Metabolism
subject: Inflammation; Complications
subject: Inflammation; Metabolism
subject: Microglia; Metabolism
subject: Monocytes; Metabolism
subject: alpha-Synuclein; Adverse effects
subject: alpha-Synuclein; Genetics
subject: Cells, Cultured
subject: Extracellular vesicles; Immunology
subject: Mice
subject: Mice, Transgenic
subject: Mutation
subject: Animals
subject: Humans
subject: Parkinson-Krankheit
subject: Immunologie
subject: Cytokine
subject: Mikroglia
subject: Monozyt
subject: Synuclein
subject: Entzündung

description: Objective Excessive inflammation in the central nervous system (CNS) and the periphery can result in neurodegeneration and parkinsonism. Recent evidence suggests that immune responses in Parkinson disease patients are dysregulated, leading to an increased inflammatory reaction to unspecific triggers. Although α‐synuclein pathology is the hallmark of Parkinson disease, it has not been investigated whether pathologic α‐synuclein is a specific trigger for excessive inflammatory responses in Parkinson disease. Methods We investigated the immune response of primary human monocytes and a microglial cell line to pathologic forms of α‐synuclein by assessing cytokine release upon exposure. Results We show that pathologic α‐synuclein (mutations, aggregation) results in a robust inflammatory activation of human monocytes and microglial BV2 cells. The activation is conformation‐ dependent, with increasing fibrillation and early onset mutations having the strongest effect on immune activation. We also found that activation of immune cells by extracellular α‐synuclein is potentiated by extracellular vesicles, possibly by facilitating the uptake of α‐synuclein. Blood extracellular vesicles from Parkinson disease patients induce a stronger activation of monocytes than blood extracellular vesicles from healthy controls. Most importantly, monocytes from Parkinson disease patients are dysregulated and hyperactive in response to stimulation with pathologic α‐synuclein. Furthermore, we demonstrate that α‐synuclein pathology in the CNS is sufficient to induce the monocyte dysregulation in the periphery of a mouse model. Interpretation Taken together, our data suggest that α‐synuclein pathology and dysregulation of monocytes in Parkinson disease can act together to induce excessive inflammatory responses to α‐synuclein. ANN NEUROL 2019;86:593–606
JupyterFAIR's Documentation: fairly package
Creators: name: Garcia Alvarez, Manuel
name: Urra Llanusa, Jose Carlos
name: Girgin, Serkan
Publisher: name: Forschungzentrum Jülich
Year: 2022
Subjects: jupterfair
fairly
data archiving
open science

description: doi:10.5281/ZENODO.7047935
description: Fairly  is a Python package that provides functionality for the core tasks of preparing, uploading and downloading datasets from research data repositories. The package currently provides integration with  Zenodo  and Fighsare repositories such as  4TU.ReseachData  This is the documentation for version v0.1.0-alpha of the fairly package.
De la notion d'objet a celle de sujet de l'ecriture: Le statut ontologique du corps dans le roman quebecois contemporain
Creators: name: Labrosse, Claudia
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Literature, Modern.
subject: Literature, Canadian (French).

description: A l'evidence, notre corps marque la condition premiere de notre existence. Aussi, cette recherche se donne pour objectif d'interroger la double nature du corps humain dans les romans quebecois depuis l'avenement de Bonheur d'occasion. En partant de l'idee, developpee par le phenomenologue Maurice Merleau-Ponty, que le corps possede a la fois une nature "objective" (par le fait qu'il soit visible pour autrui dans sa materialite, un peu a la maniere d'un objet) et une nature "phenomenale" (invisible aux autres, car il s'agit de sa nature perceptive), nous avons voulu montrer dans quelle mesure le corps depasse le statut traditionnel d'objet de l'ecriture circonscrit par la description et la gestuelle des personnages pour s'inscrire dans celui de sujet de l'ecriture, c'est-a-dire du sujet ecrivant dont le texte tire son origine. Ayant recours a un reperage systematique des procedes rhetoriques operant au sein des oeuvres une "semiotisation" de l'enveloppe chamelle, nous avons d'abord dresse une typologie des representations du corps objectif des personnages et des narrateurs autodiegetiques (le Je) en montrant que son mode de construction s'avere tributaire des fonctions discursives et narratives qu'il peut remplir dans le texte. Enfin, par l'entremise d'une analyse des techniques narratives ainsi que des elements tels que les champs lexicaux ou encore les semes relevant de la sensualite, nous avons tente d'elaborer une theorie capable de circonscrire l'inscription du corps phenomenal des personnages et des narrateurs dans l'ecriture qu'il parvient ainsi a "somatiser". En somme, il devient clair que la chair trouve toujours a investir l'oeuvre litteraire tant parce qu'elle est racontee que parce qu'elle se raconte, constat nous poussant a envisager dans le corpus quebecois l'existence non pas d'une ecriture du corps uniforme et univoque, mais de nombreuses ecritures du corps aptes a souligner la nature objective ou phenomenale du corps romanesque.
Three-dimensional optical-transfer-function analysis of fiber-optical two-photon fluorescence microscopy
Creators: name: Bird, Damian
name: Gu, Min
Publisher: name: Swinburne
Year: 2024

description: The three-dimensional optical transfer function is derived for analyzing the imaging performance in fiberoptical two-photon fluorescence microscopy. Two types of fiber-optical geometry are considered: The first involves a single-mode fiber for delivering a laser beam for illumination, and the second is based on the use of a single-mode fiber coupler for both illumination delivery and signal collection. It is found that in the former case the transverse and axial cutoff spatial frequencies of the three-dimensional optical transfer function are the same as those in conventional two-photon fluorescence microscopy without the use of a pinhole. However, the transverse and axial cutoff spatial frequencies in the latter case are 1.7 times as large as those in the former case. Accordingly, this feature leads to an enhanced optical sectioning effect when a fiber coupler is used, which is consistent with our recent experimental observation.
RNA sensing of mycobacterium tuberculosis and Its impact on TB vaccination strategies
Creators: name: Burkert, Sanne
name: Schumann, Ralf R.
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: TLR8
subject: NRLP3
subject: RLRs
subject: IL-12
subject: IL-21
subject: DDC 610 / Medicine & health
subject: Tuberculosis
subject: Host-pathogen interactions
subject: Vaccines
subject: RNA
subject: Interferon type I
subject: Tuberkulose
subject: Mycobacterium avium
subject: Impfstoff
subject: RNS

description: Tuberculosis (TB) is still an important global threat and although the causing organism has been discovered long ago, effective prevention strategies are lacking. Mycobacterium tuberculosis (MTB) is a unique pathogen with a complex host interaction. Understanding the immune responses upon infection with MTB is crucial for the development of new vaccination strategies and therapeutic targets for TB. Recently, it has been proposed that sensing bacterial nucleic acid in antigen-presenting cells via intracellular pattern recognition receptors (PRRs) is a central mechanism for initiating an effective host immune response. Here, we summarize key findings of the impact of mycobacterial RNA sensing for innate and adaptive host immunity after MTB infection, with emphasis on endosomal toll-like receptors (TLRs) and cytosolic sensors such as NLRP3 and RLRs, modulating T-cell differentiation through IL-12, IL-21, and type I interferons. Ultimately, these immunological pathways may impact immune memory and TB vaccine efficacy. The novel findings described here may change our current understanding of the host response to MTB and potentially impact clinical research, as well as future vaccination design. In this review, the current state of the art is summarized, and an outlook is given on how progress can be made.
Supporting school improvement: the development of a scale for assessing pupils' emotional and behavioural development
Creators: name: Grimley, Michael
name: Morris, Sue
name: Rayner, Stephen
name: Riding, Richard
Publisher: name: Swinburne
Year: 2024

description: This paper reports the construction of a teacher rating instrument designed to monitor the social and emotional development of school age children and young people (4-17 years). The instrument was developed by reviewing previously implemented checklists to build an extensive list of behavioural and emotional criteria and through the use of focus groups to establish the views of key stakeholders. The criteria were categorized according to three areas: conduct, emotion and learning. The initial instrument of 21 items was piloted and amended accordingly. The final trial of the instrument was carried out on a sample of 7285 pupils from a cross-section of UK schools. A principal component factor analysis confirmed the division of the scale into three factors. The instrument was supported by trends showing that the distributions were different for different types of schools and between males and females. The final version of the instrument was amended to include 15 items, five in each category (conduct, emotion, learning), all expressed positively on a six-point scale. The scale is a useful tool for providing a basis for a strategic discourse between staff in planning approaches to the emotional and behavioural development of students in school.
The benefits of Open Science: Evidence for claims made in the NWO animation on 'Open Science'
Creators: name: Jonge, Hans de
name: Cruz, Maria
Publisher: name: Forschungzentrum Jülich
Year: 2021
Subjects: Open Science
Open Access
Impact

description: doi:10.5281/ZENODO.4454973
description: The Dutch Research Council (NWO) has been a strong supporter of Open Science for many years. In 2020 we commissioned the production of a very short (1.30 minute) animation to explain what Open Science is about and why NWO thinks it is so important. The video can be viewed on the NWO website: www.nwo.nl/openscience . In this document we provide the references to scholarly literature that support the claims made in the video about the benefits of Open Science.
Context–Aware Stress Prediction System
Creators: name: Alharthi, Raneem
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Stress
Prediction
Context Aware
Cloud Computing

description: Stress is now recognized as one of the major causes of physical and psychological illness. It is known as a reaction to surrounding environmental threats and the best way to manage it is to understand its triggers. Although people continuously react to their surrounding environments, they sometimes are not aware that certain elements in their environment are considered to be stressors. Based on this fact, researchers have recently proposed context-aware stress management systems. Most of the proposed systems use context data to provide real time stress monitoring and visualization, along with intervention techniques. However, these interventions are limited to the second and tertiary stages and very little attention has been given to the primary stage. In this thesis, we introduce a system called CASP. The system’s objective is to provide stress status predictions based on a user’s current contextual data. Therefore, a detection method is developed using heart rate variability (HRV) as a stress indicator to deliver personalized context-aware stress reports. Based on the predicted status, the system provides users with stress interventions at an early stage in order to help avoid and/or eliminate the occurrence of stress. Our evaluation results show that the CASP system is able to predict the stress status of a user with an averaged accuracy of 78.23% through our limited activity, when compare to a stress status measured using physiological signals. Moreover, it provides prediction models that adapt to the changing nature of both the user’s stress status and the surrounding environment.
An accurate low-redshift measurement of the cosmic neutral hydrogen density
Creators: name: Hu, Wenkai
name: Hoppmann, Laura
name: Staveley-Smith, Lister
name: Gereb, Katinka
name: Oosterloo, Tom
name: Morganti, Raffaella
name: Catinella, Barbara
name: Cortese, Luca
name: Del Lagos, Claudia P.
name: Meyer, Martin
Publisher: name: Swinburne
Year: 2024

description: Using a spectral stacking technique, we measure the neutral hydrogen (H I) properties of a sample of galaxies at z < 0.11 across 35 pointings of the Westerbork Synthesis Radio Telescope. The radio data contain 1895 galaxies with redshifts and positions known from the Sloan Digital Sky Survey. We carefully quantified the effects of sample bias, aperture used to extract spectra, sidelobes and weighting technique and use our data to provide a new estimate for the cosmic HI mass density. We find a cosmic HI mass density of Omega(HI) = (4.02 +/- 0.26) x 10(-4) h(70)(-1) at < z > = 0.066, consistent with measurements from blind HI surveys and other HI stacking experiments at low redshifts. The combination of the small interferometer beam size and the large survey volume makes our result highly robust against systematic effects due to confusion at small scales and cosmic variance at large scales. Splitting into three sub-samples with < z > = 0.038, 0.067, and 0.093 shows no significant evolution of the HI gas content at low redshift.
Invest in Open Infrastructure: Community Response to UNESCO global call for best practices in open science
Creators: name: Sharan, Malvika
name: Herterich, Patricia
name: Kuchma, Iryna
name: Satpathy, Maheswar
name: Bennett, Arielle
name: Kramer, Bianca
name: Ramos, Irene
name: Higino, Gracielle
name: Dunks, Richard
name: Tsang, Emmy
name: Britton, Anne
Publisher: name: Forschungzentrum Jülich
Year: 2022
Subjects: UNESCO
open science
community
open infrastructure

description: doi:10.5281/ZENODO.7597883
description: Invest in Open Infrastructure ’s community response to the UNESCO Global Call for Open Science Best Practices , submitted on 15 July 2022. This response is compiled from the discussion notes from our community workshop on 8 June 2022.
Prime-Fractal Interactions under the Universal Model Framework
Creators: name: Gericke, Marco
Publisher: name: Zenodo
Year: 2025
Subjects: subject: Mathematical Physics
subject: FOS: Mathematics
subject: Fundamental Forces
subject: General Relativity
subject: Quantum Gravity

description: The Universal Model Framework (UMF) posits that space, time, and fields emerge from discrete primebased fractal structures. We extend this perspective to relate the four fundamental forces—gravity, strong, electromagnetic, and weak interactions—plus the Higgs sector, to prime-modulated potential terms. Using explicit numerical evaluations, we find that entropic gravity and fractal strong-force potentials exhibit distance-dependent behaviors reminiscent of 1/r2 and Yukawa-like forms, respectively.Additionally, we compute a prime-based electromagnetic permittivity, a weak decay coupling, and a drastically suppressed Higgs vacuum expectation value. While further refinement is needed to reconcile these results with observational data, the overall picture supports a potential route for the UMF to unify force laws through prime-fractal adjacency and fractal scaling principles.

This project was developed by Marco Gericke, with structured assistance from a large language model. All scientific concepts and conclusions were generated, verified, and interpreted by the author.

Dedicated to Peter Plichta, who envisioned the code before it could be computed.
Challenges to peer support in low- and middle-income countries during COVID-19
Creators: name: Mpango, Richard
name: Kalha, Jasmine
name: Shamba, Donat
name: Ramesh, Mary
name: Ngakongwa, Fileuka
name: Kulkarni, Arti
name: Korde, Palak
name: Nakku, Juliet
name: Ryan, Grace
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Peer support
subject: Global mental health
subject: DDC 610 / Medicine & health
subject: Mental health services
subject: Global health
subject: Mental health
subject: COVID-19
subject: Peer group
subject: Peer influence
subject: Psychische Gesundheit
subject: Peer-Group

description: Background: A recent editorial urged those working in global mental health to “change the conversation” on coronavirus disease (Covid-19) by putting more focus on the needs of people with severe mental health conditions.UPSIDES (Using Peer Support In Developing Empowering mental health Services) is a six-country consortium carrying out implementation research on peer support for people with severe mental health conditions in high-(Germany, Israel), lower middle- (India) and low-income (Tanzania, Uganda) settings. This commentary briefly outlines some of the key challenges faced by UPSIDES sites in low- and middle-income countries as a result of Covid-19, sharing early lessons that may also apply to other services seeking to address the needs of people with severe mental health conditions in similar contexts. Challenges and lessons learned: The key take-away from experiences in India, Tanzania and Uganda is that inequalities in terms of access to mobile technologies, as well as to secure employment and benefits, put peer support workers in particularly vulnerable situations precisely when they and their peers are also at their most isolated.Establishing more resilient peer support services requires attention to the already precarious situation of people with severe mental health conditions in low-resource settings, even before a crisis like Covid-19 occurs. While it is essential to maintain contact with peer support workers and peers to whatever extent is possible remotely, alternatives to faceto- face delivery of psychosocial interventions are not always straightforward to implement and can make it more difficult to observe individuals’ reactions, talk about emotional issues and offer appropriate support. Conclusions: In environments where mental health care was already heavily medicalized and mostly limited to medications issued by psychiatric institutions, Covid-19 threatens burgeoning efforts to pursue a more holistic and person-centered model of care for people with severe mental health conditions. As countries emerge from lockdown, those working in global mental health will need to redouble their efforts not only to make up for lost time and help individuals cope with the added stressors of Covid-19 in their communities, but also to regain lost ground in mental health care reform and in broader conversations about mental health in low-resource settings.
Collapse risk of tall steel moment-resisting frames in deep sedimentary basins during large magnitude subduction earthquakes
Creators: name: Molina Hutt, Carlos
name: Zahedimazandarani, Shervin
name: Marafi, Nasser
name: Berman, Jeffrey
name: Eberhard, Marc
Publisher: name: The University of British Columbia
Year: 2020

description: Buildings in Seattle, WA have the potential to experience large-magnitude earthquakes generated by the Cascadia Subduction Zone, which is located approximately 100 km from the city. Furthermore, the city lies above a deep sedimentary basin which can amplify the intensity of earthquake ground motions at long periods and the resulting damage in tall structures. Steel moment-resisting frames are of importance because of their prominence as one of the most common structural system types in the existing tall building inventory in Seattle, and due to concerns regarding the potential for fracture-prone welded connections, which came to light following the 1994 Northridge earthquake. This paper evaluates the response of a representative 1970s 50-story steel moment-resisting frame office building in Seattle under 30 simulated scenarios of a magnitude-9 Cascadia Subduction Zone earthquake. The resulting probability of collapse, conditioned on the M9 scenarios considered, is 42%. This collapse risk is greater than the 25% probability of collapse for the 975-year return period probabilistic estimate of the hazard, and it is below the 85% probability of collapse for the risk-targeted Maximum Considered Earthquake (MCER), when basin effects are considered. The estimated collapse risk exceeds by a factor of 8.5 the 10% or less probability of collapse under MCER ground motions targeted by modern codes for new design. These high collapse risks are largely driven by: (i) deep sedimentary basin effects, which amplify long period shaking; and (ii) the expected brittle behavior of fracture-prone welded beam-to-column connections. The performance of the building under the M9 scenarios outside of the basin or with ductile beam-to-column connections result in a negligible probability of collapse.
Redefining the limits to thought within media culture: Collective memory, cyberspace and the subversion of mass media.
Creators: name: Strangelove, Michael William.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Anthropology, Cultural.

description: This dissertation examines how cyberspace will impact upon mass media's socialization process within media culture. Mass media is defined as an elite-owned system which produces a limited number of symbols that socialize the audience according to the requirements of the economic system. The audience of mass media is described as located within media culture which is the location of media's symbol-flow. Cyberspace is defined as structurally-differentiated from mass media. Its distributed design has made it impossible for monopolistic ownership or state control to regulate completely the flow of symbols (communication and content production). Thus I conclude that cyberspace represents the democratization of symbol-flow (or the radicalization of free expression) within media culture. Case studies of media texts and events demonstrate the structurally-differentiated symbol-flow of mass media and cyberspace, the former being highly-constrained by the economic system, the latter exhibiting a highly-unconstrained flow of symbols (with symbols equivalent to shared meaning and values). With these two different types of media systems, constrained and unconstrained symbol-flow, I then apply a model of symbol-flow as a form of cultural reproduction. Mary Douglas' theory of collective memory describes culture as the arena of shared implicit assumptions about humans and nature. These assumptions are embedded in symbols which act as a form of social meta-communication. The social order is communicated through the symbols which are in use within social interaction. Collective memory allows us to analyse mass media as a highly-controlled form of social reproduction (thus the success and power of its socialization process is explained). Collective memory also allows us to identify how cyberspace will impact upon the socialization process of mass media. If the economic system is highly dependent upon mass media's constrained flow of symbols for its socialization effect (and it is), then unconstrained communication/symbol-flow within cyberspace represents the potential subversion of the dominant meanings and values which are reproduced through mass media. I argue that cyberspace potentially undermines the socialization process established through mass media. Collective memory provides a tool for examining the implications of a structurally-differentiated mode of communication (cyberspace) which has arisen within media culture in the late twentieth century.
IL1R2, CCR2, and CXCR4 may form heteroreceptor complexes with NMDAR and D2R: relevance for schizophrenia
Creators: name: Borroto-Escuela, Dasiel O.
name: Tarakanov, Alexander O.
name: Bechter, Karl
name: Fuxe, Kjell
Publisher: name: Universität Ulm
Year: 2017
Subjects: subject: receptor–receptor interactions
subject: NMDAR
subject: chemokine receptors
subject: cytokine receptors
subject: heteroreceptor complexes
subject: volume transmission
subject: neuroinflammation
subject: DDC 570 / Life sciences
subject: DDC 610 / Medicine & health
subject: Schizophrenia
subject: Inflammation
subject: Receptors, Chemokine
subject: Receptors, Cytokine
subject: Receptors, N-Methyl-D-Aspartate
subject: Schizophrenie
subject: Entzündung
subject: Chemokine
subject: NMDA-Rezeptor

description: The mild neuroinflammation hypothesis of schizophrenia was introduced by Bechter in 2001. It has been hypothesized that a hypofunction of glutamatergic signaling via N-methyl-D-aspartate receptors (NMDARs) and hyperactivation of dopamine D2 receptors play a role in schizophrenia. The triplet puzzle theory states that sets of triplet amino acid homologies guide two different receptors toward each other and contributes to the formation of a receptor heteromer. It is, therefore, proposed that putative NMDAR-C-C chemokine receptor type 2 (CCR2), NMDAR-C-X-C chemokine receptor type 4 (CXCR4), and NMDAR- interleukin 1 receptor type II (IL1R2) heteromers can be formed in the neuronal networks in mild neuroinflammation due to demonstration of Gly-Leu-Leu (GLL), Val-Ser-Thr (VST), and/or Ser-Val-Ser (SVS) amino acid homologies between these receptor protomers. This molecular process may underlie the ability to produce symptoms of schizophrenia in mild neuroinflammation. In this state, volume transmission (VT) is increased involving increased extracellular vesicle-mediated VT from microglia and astroglia. These vesicles may contain CCR2, CXCR4, and/or IL1R2 as well as their ligands and upon internalization by endocytic pathways into neurons can form heteroreceptor complexes with NMDAR in the plasma membrane with pathological allosteric receptor–receptor interactions involving increased internalization and reduced NMDAR signaling. The triplet puzzle theory also suggests the formation of putative D2R-CCR2, D2R-CXCR4, and D2R-IL1R2 heteromers in mild neuroinflammation in view of their demonstrated sets of Leu-Tyr-Ser (LYS), Leu-Pro-Phe (LPF), and/or Ser-Leu-Ala (SLA) triplet homologies. These D2R heteroreceptor complexes may also contribute to schizophrenia-like symptoms in mild neuroinflammation by enhancing D2R protomer function.
Taking Open Science into account when writing your project proposal
Creators: name: Féret, Romain
name: Bracco, Laetitia
name: Cheviron, Stéphanie
name: Lehoux, Elise
name: Arènes, Cécile
name: Li, Ling
Publisher: name: Forschungzentrum Jülich
Year: 2020
Subjects: Open Science
Data management
Research data
Open access
Research projects
ANR

description: doi:10.5281/ZENODO.3773762
description: Since 2019, the ANR has implemented Open Science requirements (Open Access and Data Management Plan) for projects funded under the 2019 and subsequent calls for projects. If the funded projects have obligations, the project leaders can anticipate them as early as the grant proposal writing phase. It allows them to improve the feasibility of their project by identifying institutional services that can support them as well as the requested means to implement an ambitious Open Science strategy. Anticipating these aspects can also facilitate collaborations within teams and consortia so that Open Science is an opportunity rather than a constraint.