cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Bone morphogenetic protein 4 is induced in hepatocellular carcinoma by hypoxia and promotes tumour progression
Creators: name: Maegdefrau, Ulrike
name: Amann, Thomas
name: Winklmeier, Andreas
name: Braig, Simone
name: Schubert, Thomas
name: Weiss, Thomas S.
name: Schardt, Katharina
name: Warnecke, Christina
name: Hellerbrand, Claus
name: Bosserhoff, Anja‐Katrin
Publisher: name: Universität Regensburg
Year: 2009
Subjects: subject: hepatocellular carcinoma bone morphogenetic protein 4 transcriptional regulation invasion ets-1 hypoxia
subject: 610 Medizin

description: Abstract

Striking similarities exist between molecular mechanisms driving embryonic liver development and progression of hepatocellular carcinoma (HCC). Bone morphogenetic proteins (BMPs), particularly BMP4, have been proposed to regulate embryonic hepatic development. BMP expression has been observed in neoplasia but the expression and biological role of BMP4 in human HCC are unknown. We found increased BMP4 mRNA and protein in HCC cell lines and tissue samples compared to primary human hepatocytes and corresponding non-tumourous tissue. Hypoxia further induced BMP4 expression in HCC cells, which was abolished by transfection of a dominant negative form of HIF-1alpha (dnHIF-1alpha). However, gel shift assays revealed only minor binding activity in nuclear extracts from (hypoxic) HCC cells to a putative hypoxia-response element in the BMP4 promoter. Sequence analysis of the BMP4 promoter revealed two Ets-1 binding sites, and Ets-1 activity was increased in HCC cells under hypoxic conditions. Transfection of dnHIF-1alpha completely abrogated hypoxia-induced Ets-1 activity as well as BMP4 expression. Overexpression of Ets-1 markedly enhanced BMP4 promoter activity, while antisense Ets-1 almost completely abolished basal as well as hypoxia-induced BMP4 expression. These data demonstrate that Ets-1 activity contributes to baseline expression of the BMP4 gene and is the predominant mediator of the HIF-dependent BMP4 induction under hypoxic conditions. To determine the functional relevance of BMP4 expression, HCC cell lines were treated with antisense BMP4 constructs or siRNA against BMP4. BMP4 suppression resulted in a strong reduction of the migratory and invasive potential and anchorage-independent growth. Furthermore, tube formation assays indicated that BMP4 expressed by HCC cells promotes vasculogenesis. Our findings demonstrate that BMP4 is increased in HCC and promotes HCC progression. Therefore, BMP4 expression may have clinical relevance, and interfering with BMP4 signalling appears as an attractive therapeutic target for this highly aggressive tumour.
A multigene phylogeny of Olpidium and its implications for early fungal evolution
Creators: name: Sekimoto, Satoshi
name: Rochon, D’Ann
name: Long, Jennifer E.
name: Dee, Jaclyn M.
name: Berbee, Mary L.
Publisher: name: BioMed Central
Year: 2016

description: Background: From a common ancestor with animals, the earliest fungi inherited flagellated zoospores for dispersal in water. Terrestrial fungi lost all flagellated stages and reproduce instead with nonmotile spores. Olpidium virulentus (= Olpidium brassicae), a unicellular fungus parasitizing vascular plant root cells, seemed anomalous. Although Olpidium produces zoospores, in previous phylogenetic studies it appeared nested among the terrestrial fungi. Its position was based mainly on ribosomal gene sequences and was not strongly supported. Our goal in this study was to use amino acid sequences from four genes to reconstruct the branching order of the early-diverging fungi with particular emphasis on the position of Olpidium. Results: We concatenated sequences from the Ef-2, RPB1, RPB2 and actin loci for maximum likelihood and Bayesian analyses. In the resulting trees, Olpidium virulentus, O. bornovanus and non-flagellated terrestrial fungi formed a strongly supported clade. Topology tests rejected monophyly of the Olpidium species with any other clades of flagellated fungi. Placing Olpidium at the base of terrestrial fungi was also rejected. Within the terrestrial fungi, Olpidium formed a monophyletic group with the taxa traditionally classified in the phylum Zygomycota. Within Zygomycota, Mucoromycotina was robustly monophyletic. Although without bootstrap support, Monoblepharidomycetes, a small class of zoosporic fungi, diverged from the basal node in Fungi. The zoosporic phylum Blastocladiomycota appeared as the sister group to the terrestrial fungi plus Olpidium. Conclusions: This study provides strong support for Olpidium as the closest living flagellated relative of the terrestrial fungi. Appearing nested among hyphal fungi, Olpidium's unicellular thallus may have been derived from ancestral hyphae. Early in their evolution, terrestrial hyphal fungi may have reproduced with zoospores.
STRATEEGILINE NARRATIIV: PEHME JÕU UUS KÄSITLUS
Creators: name: Roselle, Laura
name: Miskimmon, Alister
name: O'Loughlin, Ben
Publisher: name: The Estonian Journal of Military Studies
Year: 2024

description: Soft power in its current, widely understood form has become a straitjacket for those trying to understand power and communication in international affairs. Analyses of soft power overwhelmingly focus on soft power ‘assets’ or capabilities and on ways to wield them, not the ways how influence does or does not take place. It has become a catch-all term that has lost explanatory power, just as hard power once did. The authors argue that the concept of strategic narrative gives us intellectual purchase on the complexities of international politics today, especially with regard to how influence works in a new media environment. They believe that media and war studies would benefit if more attention was being paid to strategic narratives.
description: The Estonian Journal of Military Studies, No. 17 (2021)
RANNIKUVÕIM: RANNIKURIIGI MEREVÕIM JA MERELISTE RESSURSSIDE HALDAMINE
Creators: name: Børresen, Jacob
Publisher: name: The Estonian Journal of Military Studies
Year: 2024

description: This article will present a theory of the sea power of the coastal state – or what one might call coastal power – and in that context discuss the preconditions for and the limits to the ability of the coastal state to protect and defend itself and the resources in its Exclusive Economic Zone [EEZ] and on its continental shelf. Finally, the theory will be applied to the role and mission of the Royal Norwegian Navy (RNoN). The basis for this theory is not an analysis of navies of over 100 coastal states that has helped to identify their common denominators. The theory of coastal power is, therefore, not primarily descriptive, although it contains descriptive passages. On the contrary, it has a clearly prescriptive or normative bias. Using the experiences of the Norwegian Navy as an example, the coastal theory suggests ways how a small state with an ocean coastline can perceive sea power and apply naval forces to increase their freedom of action and, thus, develop and protect their interests. Evidently, the coastal power theory could apply to all coastal states. The order of battle, the doctrine, and the concept of operations of each individual coastal navy can, of course, greatly vary in terms of their specific role and tasks, but this concerns the particular characteristics of individual coastal states and challenges to their security.
description: The Estonian Journal of Military Studies, No. 16 (2021)
KAS KA VÄIKERIIGID VAJAVAD TASAKAALUS LAEVASTIKKU?
Creators: name: Urb, Taavi
Publisher: name: The Estonian Journal of Military Studies
Year: 2024

description: For a coastal state, the maritime domain presents opportunities as well as dangers that cannot be ignored. To defend its sovereignty and interests at sea, a coastal state needs maritime forces that can at least display its presence at sea and act as a tripwire against definite forces. This becomes especially important at a grey zone between peace and war. For a small state, there is no clear distinction between internal and external security within a maritime domain, and the line between war and peace is becoming increasingly fuzzier. A balanced fleet that is able to operate through a whole conflict spectre and maintain at least some capabilities in all principal warfare areas is the best solution for maintaining the sovereignty of a state and protecting its interests at sea. To create a balanced fleet, a navy requires a fair share of the (defence) budget. Small states have some inherit problems regarding the establishment and maintenance of a capable fleet, especially shortness of financial and human recourses but also lack of knowledge; however, abolishing a navy or degrading it to a niche navy is not an advisable solution. It way may seem efficient to sacrifice the protection of national maritime interests, but in no way does it support an independent defence capability of a state. Avoiding duplications and factionalism, promoting intra- and interstate cooperation and jointness, and combining it with a conscious innovation should make the maintenance of a balanced fleet affordable even for a small state. All in all, there are no credible alternatives to developing a balanced fleet, even for a small coastal state.
description: The Estonian Journal of Military Studies, No. 16 (2021)
SEA POWER IN THE BALTIC SEA
Creators: name: Laanemets, Ott
Publisher: name: The Estonian Journal of Military Studies
Year: 2024

description: This article contributes to the discussion of maritime security by assessing the elements of sea power of the Baltic coastal states, focusing on state-on-state interaction. The research question that will be answered is: what is the character and importance of sea power for the Baltic Sea nations in the contemporary geopolitical setting? The article consists of theoretical and empirical parts. In the former, theoretical frameworks of national power, geopolitics, sea power, and small state sea power – coastal power – are created. In the latter, four elements of sea power – geographical, social, economic, and military – across the Baltic Sea nations are analysed. The methodology used is qualitative comparative analysis (so-called ‘small N’), where the cases are the sea powers of the Baltic Sea countries and the units of analysis are the above-mentioned elements of sea power. The main results of this research are the following: the nature of sea power in the Baltic Sea is the same as for great powers; however, its character is different. The importance of sea power in the Baltic Sea springs from geography, which for both economic and military elements mainly means assuring access. This importance, however, is not appreciated by Western oriented Baltic Sea countries whose sea power manifests in small merchant fleets, insufficient numbers of warships, and capability gaps for Baltic operations.
description: The Estonian Journal of Military Studies, No. 16 (2021)
title: 01_0777
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
EESTI ENERGIAJULGEOLEKU TAGAMINE KUI MEREVÄE ÜKS PÕHIÜLESANDEID
Creators: name: Urbus, Urmo
Publisher: name: The Estonian Journal of Military Studies
Year: 2024

description: This article focuses on the concept that energy security should be one of the main objectives of the Estonian Navy. The article is divided into three parts. The first part argues that the main maritime resource of Estonia are cables that keep us connected to other energy grids besides the one of Russia. These connections increase Estonian energy security. The second part provides an overview of the current energy situation in Estonia and the third part will provide insight on the close bond of energy security and the navy. Sustainable defence requires significant resources and energy is one of the most important resource. Currently, the main energy supplier in the North-Eastern region of the Baltic Sea is Russia. The international relations between the Baltics and Russia are contested, and in addition to that, the relations between NATO and the Russian Federation are somewhat substandard. This has created a situation where the countries on the Baltic Sea that are adjacent to Russia have to try to disconnect from Russian energy grids and move towards the Western ones to create a stable balance of power between actors. It is reasonable to assume that during an armed conflict between Russia and Estonia, one of the main targets would be the Narva Power Plants due to their proximity to the Russian-Estonian border and operational importance. If the power plant is compromised, a large part of Estonia would be left without power, which would hinder military defence. However, it would be possible to use underwater resources, more specifically, Estlink and Balticconnector cables to mitigate this. For this reason, the priority of the Estonian Navy should be to defend these cables and ensure energy security during a conflict. My argument is that the Estonian Navy and Estonian energy security are strongly tied, and a similar argument could be made about the Russian Navy and energy security at the Baltic Sea. I argue that the most important maritime resource for Estonia is situated between Tallinn and Helsinki: the cables and gas pipelines. For this reason, I propose that this area should be a priority and, during wartime, working control should be established in that specific area. Sea denial should be established in adjacent areas to support the main goal of energy security. This would, in turn, ensure the sustainability of defence, both at sea and on land.
description: The Estonian Journal of Military Studies, No. 16 (2021)
Antifibrotic effects of curcumin are associated with overexpression of cathepsins K and L in bleomycin treated mice and human fibroblasts
Creators: name: Zhang, Dongwei
name: Huang, Chuangfang
name: Yang, Changfu
name: Liu, Renzuo J
name: Wang, Jifeng
name: Niu, Jianzhao
name: Brömme, Dieter
Publisher: name: BioMed Central
Year: 2016

description: Background: Lung fibrosis is characterized by fibroblast proliferation and the deposition of collagens. Curcumin, a polyphenol antioxidant from the spice tumeric, has been shown to effectively counteract fibroblast proliferation and reducing inflammation and fibrotic progression in animal models of bleomycin-induced lung injury. However, there is little mechanistic insight in the biological activity of curcumin. Here, we study the effects of curcumin on the expression and activity of cathepsins which have been implicated in the development of fibrotic lung diseases. Methods: We investigated the effects of curcumin administration to bleomycin stimulated C57BL/6 mice and human fetal lung fibroblasts (HFL-1) on the expression of cathepsins K and L which have been implicated in matrix degradation, TGF-β1 modulation, and apoptosis. Lung tissues were evaluated for their contents of cathepsins K and L, collagen, and TGF-β1. HFL-1 cells were used to investigate the effects of curcumin and cathepsin inhibition on cell proliferation, migration, apoptosis, and the expression of cathepsins K and L and TGF-β1. Results: Collagen deposition in lungs was decreased by 17-28% after curcumin treatment which was accompanied by increased expression levels of cathepsins L (25%-39%) and K (41%-76%) and a 30% decrease in TGF-β1 expression. Moreover, Tunel staining of lung tissue revealed a 33-41% increase in apoptotic cells after curcumin treatment. These in vivo data correlated well with data obtained from the human fibroblast line, HFL-1. Here, cathepsin K and L expression increased 190% and 240%, respectively, in the presence of curcumin and the expression of TGF-β1 decreased by 34%. Furthermore, curcumin significantly decreased cell proliferation and migration and increased the expression of surrogate markers of apoptosis. In contrast, these curcumin effects were partly reversed by a potent cathepsin inhibitor. Conclusion: This study demonstrates that curcumin increases the expression of cathepsins K and L in lung which an effect on lung fibroblast cell behavior such as proliferation, migration and apoptosis rates and on the expression of TGF-β1 in mouse lung and HFL-1 cells. These results suggest that cathepsin-inducing drugs such as curcumin may be beneficial in the treatment of lung fibrosis.
Deliverable 6.3 – Recommendations for novel structures for governance: academic and industrial participation
Creators: name: Bokor, Balazs
Publisher: name: Zenodo
Year: 2024

description: EELISA InnoCORE Work Package 6 (WP6) primarily deals with reinforcing the cooperation in research and innovation with other sectors, especially with respect to the academia-business cooperation. The main objectives are to reinforce Research and Innovation Dimension of universities via the concept of Science Parks; to meet the transformative challenge of reshaping university operations to provide services for industrial, economical and societal development; to construct a dynamic university innovation ecosystem among the consortium members.

The current report addresses the governance possibilities of three specific instruments:

- EELISA Science Park

- EELISA research- and entrepreneurship focused internships

- EELISA Industrial Chari/Professor position

For each instrument, the current practices and typical policies are briefly summarized and illustrated, well citing to the relevant work packages and their results.

Based on the discussion on InnoCORE level, recommendations are given for the governances of these structures, that shall be again reviewed and finetuned during implementation.
description: (DRAFT NOT YET APPROVED BY EUROPEAN COMMISSION)
EESTI MEREKAITSE TULEVIKUSTSENAARIUMID
Creators: name: Roosipuu, Tauri
Publisher: name: The Estonian Journal of Military Studies
Year: 2024

description: The problems of organising Estonian maritime defence have been the topic of discussion ever since the country restored independence, but not yet acknowledged on a governmental and societal level, and no substantial reorganisation have been made so far. The objective of this article is to propose two hypothetical and extreme future scenarios that could take place over the next thirty years, both positive and negative, based on the current situation of maritime defence in Estonia. The first (the black scenario) is based on the assumption that there will be negative developments over the next decades, and maritime defence in Estonia will significantly deteriorate. However, the second (the white scenario) is based on the opposite assumption: a positive development will follow and Estonian maritime defence will dramatically improve. The organisation of maritime defence in Estonia is at a crossroads. It is not sustainable in its current state, even in terms of maintaining the existing capabilities, and will create more and more problems over time. The implementation of either scenario depends primarily on the spread of a maritime mind-set. In the case of the black scenario, Estonian maritime geography would continue to be ignored on a governmental and political level, and that includes national defence management. In the case of the positive alternative, national maritime interests would be defined, the management of the maritime sector reorganised, legislations revised, and the necessary reforms implemented to ensure the sovereignty of Estonian sea areas. Another factor is the national organisation of sea surveillance and the compilation of a recognised maritime picture which is a basis for all maritime operations. With the black scenario, it would remain fragmented between different agencies/authorities and the responsibility of sea surveillance would not be regulated on a legislative level. In case of the white scenario, sea surveillance would be assigned to the Defence Forces and they would compile a recognised maritime picture (in accordance with wartime requirements) with stationary and mobile shore radars and vessels permanently displaying the national flag and identifying targets on Estonian sea areas.


 
 
description: The Estonian Journal of Military Studies, No. 16 (2021)
Algoritmi di ottimizzazione per la stima del movimento dell'apparato locomotore umano usando la misura delle sole reazioni vincolari
Creators: name: Bailo, Daniele
Publisher: name: Zenodo
Year: 2020
Subjects: biomeccanica, reazioni vincolari, simulated annealing

description: Il presente lavoro di ricerca biomeccanica è volto a validare il Modello ad Ingresso Misurato Minimo JAGO in modo da valutarne l’utilizzo in ambito clinico, e verificarne l’affidabilità per la risoluzione del problema della valutazione funzionale. In particolare si concentra sul processo di ottimizzazione per la generazione delle traiettorie dei segmenti articolari, a partire dalle sole reazioni vincolari, validando il modello JAGO sui dati sperimentali. Vengono fissati dapprima dei criteri per le misure da effettuare sul soggetto, in seguito viene confrontata la cinematica delle articolazioni di un soggetto che compie il gesto motorio dello squat stimata dal modello, con quella misurata tramite un apparato di misura stereofotogrammetrico.
EESTI MEREVÄE ÜLESANNE PEAB OLEMA PIIRATUD MEREALA VALDAMINE, MITTE VALDAMISE TAKISTAMINE
Creators: name: Gavrilov, Grigori
Publisher: name: The Estonian Journal of Military Studies
Year: 2024

description: Despite the emergence of new “revolutionary” technologies, the reality of war seldom changes instantly and is more often than not an evolution, rather than a revolution. The same applies for warfare in general, and naval warfare in particular. The first theorists of naval warfare (e.g. A. T. Mahan, J. Corbett, P. H. Colomb, S. Makarov) wrote about the age of sail at a time when wooden-hulled ships and smoothbore cannons had not yet lost their relevance in naval warfare. Still, the most significant statements of the XIX century thinkers stood the test of time and remain relevant even at the age of nuclear propulsion and supersonic missiles. Most naval theorists generally accept two maxims. The first, established already by naval thought pioneers, states that the ultimate purpose of all operations at sea is to influence the events on land. The second maxim focuses more specifically on conducting war at sea. In general terms, it describes two different approaches to naval warfare. The first is a pursuit of sea control. Sea control is a situation where one side is able to use the sea for achieving its objectives, either as a transport medium (for both troops and goods) or a projection of their power from the sea (i.e. amphibious operations or strike warfare). The second is a pursuit of sea denial. It can be described as a situation that precludes the use of the sea by an opponent, without necessarily allowing oneself to use the sea instead. It is important to understand that sea control and sea denial are not antipodes. If one side achieves sea control, the sea is automatically denied to the other belligerent. However, successfully achieving sea denial does not automatically give one the ability to use the sea freely for personal purposes. It is an important rationale for the subsequent discussion.
description: The Estonian Journal of Military Studies, No. 16 (2021)
ORGANISATSIOONIARHITEKTUUR JA VÕIMEPÕHINE PLANEERIMINE – TÕHUSA RIIGI TÖÖRIISTAD
Creators: name: Peets, Ivo
Publisher: name: The Estonian Journal of Military Studies
Year: 2024

description: The second law of thermodynamics, which in essence is universal, exists in the universe. A simple version of it explains that everything in the world moves involuntarily towards greater chaos and disorder, i.e. entropy keeps increasing. In order to reduce disorder or entropy it is essential to work not only to create material and intellectual values, but also to plan activities. We need to find and make use of the right “tools” to make the process of reducing the growth of entropy more effective. The present article elaborates on some of such tools from a vast variety. The research topic of the article emerged from the practical professional experience that cooperation between the state’s different areas of responsibility could be improved, as shortcomings in planning and common situational awareness became evident at the stage of drafting plans. This, in turn pointed to drawbacks in the accepted planning methods and also to possibilities to improve cross-sector exchange of information and cooperation by implementing uniform planning methods across sectors. Over some time, the defence domain has successfully implemented capability-based planning principles, which led to the question whether the method of capability-based planning could work for other domains as well and how this could assist in improving their cooperation. The study confirmed that capability-based planning methods could be applied together with the high-potential enterprise architecture method. The objective of the article was to confirm the above stated standpoints. The comparative analysis of planning methods, together with tracing possible faults that may emerge in their interaction, indicated that capability planning methods may be applied jointly with enterprise architecture methods. This kind of approach has the potential to improve the cooperation of state institutions and raise the general knowledge of situational awareness. To reach this objective, the mentioned methods were analysed in order to discover possible weaknesses and faults in their comparison and interaction, as well as their desired positive effects.


 
 
description: The Estonian Journal of Military Studies, No. 15 (2020)
ELUTÄHTSATE TEENUSTE RISTSÕLTUVUSTE ANALÜÜS
Creators: name: Laud, Peeter
name: Bahsi, Hayretdin
name: Lenin, Aleksandr
name: Mändmaa, Kalev
name: Priisalu, Jaan
name: Tuuling, Reedik
Publisher: name: The Estonian Journal of Military Studies
Year: 2024

description: Awareness of undesirable events happening in the country, and of their consequences is a major part of the comprehensive national defense approach. Knowing and forecasting the status of life-critical services is part of this awareness. A drop in the supply of one of the services may have far-reaching effects, and so may a surge in demand. This paper reports on our work in formalizing the dependencies between the supply and demand of services in the Estonian context. Our formalization depends on a suitable metamodel, i.e. a formal language for expressing the dependencies. The language has to be sufficiently expressive to capture the essential types of dependencies, but not overly expressive, as this would hinder the analysis. We have performed a review of the attributes of services and dependencies referred to in relevant literature, and have concluded that despite the richness in their structure, only the level of rendered services (expressed numerically), their changes in time, and their dependencies on the current and past levels of other services should be included in the metamodel. More complex services, e.g. the provision of electrical power, whose level cannot be expressed as a single number, should be characterized by a tuple of numbers (e.g. the availability of power at each substation). In addition to the characteristics of the services, the metamodel allows the description of environmental events, using the same formalism. The examples of such events are weather conditions, as well as drops in the levels of external services, all characterized by their time of occurrence and duration. Given this ability to model the effects of external events, we can construct scenarios and run simulations to find out how well the infrastructure (according to our model) copes with such events in such sequence.
description: The Estonian Journal of Military Studies, No. 15 (2020)
SÜSTEEMIDE SÜSTEEMI OLUKORRA HINDAMISEST SELLE KOMPONENTIDE VÕIMEMUDELITE ABIL
Creators: name: Mõtus, Leo
name: Teichmann, Mare
name: Meriste, Merik
name: Rannat, Kalev
name: Priisalu, Jaan
name: Kaugerand, Jaanus
Publisher: name: The Estonian Journal of Military Studies
Year: 2024

description: In real life we sometimes stumble on a problem of assessing situational awareness (SA) of holistic system of systems that is composed of many interoperating heterogeneous organisations – e.g. country’s comprehensive (all-embracing) defence system that comprises military organisations, law enforcement organisations (including rescue agencies), critical infrastructure organisations, and others. For managing and controlling the behaviour of any system of systems we need near real-time decision-making ability that stems from the measurements taken via models of constituent systems. This paper suggests using near real-time measurements taken from capability-based models for estimating SA in constituent system. It is true that capability-based models provide only partial and approximate information about the situation awareness of system of systems. At the same time, capability- based models, due to their near real-time and (verifiable) trustworthy data improves the decision-making quality, as compared with potential decisions stemming from the conventionally provided statistical data. Capability-based models come from the DoDAF (Department of Defence Architecture Framework) methodology and are identified as Capability Viewpoint models (class CV-2) that are built on capability taxonomy. Capability taxonomy is an important simplifying factor, since quite often assessment of status of only some taxonomy elements is sufficient for estimating the health condition of the particular capability.
description: The Estonian Journal of Military Studies, No. 15 (2020)
title: 02_1679
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Establishment of reference intervals of homocysteine, cysteine, and methionine in apparently healthy Chinese adults
Creators: name: Cui, Xueting
name: Xu, Jieshi
name: Liu, Mingli
name: Ren, Guocheng
name: Cao, Yunfeng
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: It has been widely reported that the key biomarkers of homocysteine metabolic pathways have emerged as markers or independent risk factors for cardiovascular disease and many other diseases. To improve the accuracy of evaluation in China, we establish the reference intervals of serum homocysteine (Hcy), cysteine (Cys), and methionine (Met) in apparently healthy Chinese adults. We examined 1553 subjects aged ≥20 years who underwent Hcy metabolic pathway tests, in the Chaoyang Central Hospital between January 2019 and December 2020. The serum Hcy, Cys, and Met levels were simultaneously determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Multiple regression analysis was performed to identify sources of variation. A nonparametric method was used to establish the reference intervals. Gender differences were observed in Hcy and Met, with higher levels in males. Reference intervals for males were 6.09–17.00 μmol/L (Hcy) and 19.31–33.68 μmol/L (Met); conversely, the reference intervals for females were 4.61–14.61 μmol/L (Hcy) and 16.16–30.35 μmol/L (Met). The serum Cys reference intervals were seen to be gender-independent, but age-dependent reference intervals were needed; those for Cys were 188.85–334.27 μmol/L, 200.48–340.66 μmol/L, and 216.03–349.67 μmol/L in <40, 40–50, and ≥50 years, respectively. By this study, the gender- or age-specific reference intervals of Hcy, Cys, and Met that were matched with the Chinese population were established, providing valuable references for clinical work and laboratory researches.
Association of State COVID-19 Vaccination Prioritization With Vaccination Rates Among Incarcerated Persons
Creators: name: Leifheit, K.M.
name: Skinner, A.
name: Mitchell, C.R.
name: Raifman, J.
name: Brinkley-Rubinstein, L.
name: Biondi, B.E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Risk of COVID-19 transmission is increased in prisons and surrounding communities. COVID-19 can spread rapidly in these facilities owing to crowding, inability to socially distance, poor ventilation, continuous admissions and releases, and daily work staff. High rates of chronic and immunocompromising conditions such as HIV among incarcerated persons are associated with greater risk of COVID-19.
OLUKORRATEADLIKU KÄITUMISE MATKIMINE OTSUSTUSTOES
Creators: name: Meriste, Merik
name: Rannat, Kalev
name: Mõtus, Leo
name: Teichmann, Mare
name: Kelder, Tõnis
name: Helekivi, Jüri
Publisher: name: The Estonian Journal of Military Studies
Year: 2024

description: This article is a comprehensive overview about common issues in situation-aware modeling to support decision making. The main focus is on implementation of tunable models in agent-based simulations for investigating the behavioral patterns of simulation agents representing real world actors in crisis management or logistics in a dynamic operational environment. Modeling of situational awareness and analysis of explicit behavior of agents is an essential part of simulation-based decision support. The article consists of the subsections about generic issues of decision support and distributed situation awareness. A special emphasis is placed on reckoning with the real environmental conditions and usage of realistic information for parameterizing the simulation models and agents. The work is illustrated with examples from different projects with practical implementation of agent-based simulations for decision support in crisis management and allocation of resources. All examples are implemented with the same methodology and in the same ProLab simulation environment.
description: The Estonian Journal of Military Studies, No. 15 (2020)
MANTICUS APOLLO PROJEKTI SÕJAMÄNG JA SELLE TULEMUSED
Creators: name: Dieves, Veiko
Publisher: name: The Estonian Journal of Military Studies
Year: 2024

description: The aim of the Manticus Apollo project was to propose the architecture of a situational awareness system for comprehensive defence. In order to examine the situational awareness support system ability to improve situational awareness, it was first necessary to examine the situational awareness of the parties involved in comprehensive defence in resolving complex situations. To fulfill the sub-goal of the project, a war game application and a war game scenario were created. This article gives an overview of the application of the war game and the results of the war game. It describes the previous use of war game simulations in the study of command and control approaches, the war game application developed during the Manticus Apollo project, and the theoretical starting points of command and control approaches.


 
 
description: The Estonian Journal of Military Studies, No. 15 (2020)
Drones for parcel and passenger transportation: A literature review
Creators: name: Kellermann, Robin
name: Biehle, Tobias
name: Fischer, Liliann
Publisher: name: Technische Universität Berlin
Year: 2020
Subjects: subject: 600 Technik, Technologie
subject: drones
subject: UAV
subject: logistics
subject: passenger transportation
subject: literature review
subject: content analysis
subject: technology assessment

description: Delivery drones and ‘air taxis’ are currently among the most intensely discussed emerging technologies, likely to expand mobility into the ‘third dimension’ of low-level airspace. This paper presents a systematic literature review of 111 interdisciplinary publications (2013 - 03/2019). The review systematizes the current socio-technical debate on civil drones for transportation purposes allowing for a (critical) interim assessment. To guide the review process four dimensions of analysis were defined. A total of 2581 relevant quotations were subdivided into anticipated barriers (426), potential problems (1037), proposed solutions (737) and expected benefits (381). We found that the debate is characterized by predominantly technical and regulatory problems and barriers which are considered to prevent or impede the use of drones for parcel and passengers transportation. At the same time, definite economic expectations are juxtaposed with quite complex and differentiated concerns regarding societal and environmental impacts. Scrutinizing the most prevalent transportation-related promises of traffic reduction, travel time saving and environmental relief we found that there is a strong need to provide scientific evidence for the promises linked to the use of drones for transportation. We conclude that the debate on drones for transportation needs further qualification, emphasizing societal benefits and public involvement more strongly.
Testing causal associations in language change: The replacement of subordinating then with when in Middle English.
Creators: name: Zimmermann, Richard
Publisher: name: Journal of Historical Syntax
Year: 2020

description: Middle English changes the realization of temporal subordinators from a th-form (then) to a wh-form (when). The innovation is quantified with data from four syntactically parsed corpora. The change may have had an antecedent cause in the loss of subject-verb inversion after clause-initial adverb then. This view is supported by the time course of the two developments, the loss of subject-verb inversion slightly preceding the rise of wh-based subordination, as well as by the fact that the presence of alternative subordinating strategies inhibit the presence of wh-subordinators. The paper thus provides quantitative, empirical evidence for language-internally motivated change.
description: Journal of Historical Syntax, Vol 4 No 4 (2020)
Simulating the effect of adding vegetative buffers around poultry barns on mean wind and concentrations of PM10
Creators: name: Pauls, Daryll
name: Christen, Andreas
Publisher: name: University of British Columbia
Year: 2012

description: Controlling emissions of particulate matter from poultry facilities is desirable to mitigate negative impacts of emissions on natural resources and human health. A potential emission management strategy is to enhance deposition on ground and vegetation inside the property line and consequently reduce dispersion to neighbouring properties. This can be possibly achieved though planting of vegetative buffers on and around poultry facilities. This report evaluates and applies a simple building-resolving flow and dispersion model to determine the effects of adding vegetation buffers around poultry barns to mitigate particulate matter (PM10) emissions leaving the property line. Different buffer layouts were studied and their potential on reducing wind, increasing concentration and deposition of PM10 was evaluated. Two different buffer layout scenarios were tested - a perimeter planting and an infill of the alleyway between barns. Sensitivities to plan area density, leaf area density and height of the vegetative buffer are quantified in terms of decreasing wind and increasing concentrations of PM10 at screen level. The model estimates that deposition on buffer vegetation was minor, and only about ~10% of the emitted PM10 could be removed by dry deposition. In none of the modeled scenarios, total PM10 leaving the property was significantly reduced. The model does not include effects of wet deposition and impactation, which could further enhance removal.
ÕPIKOGEMUSE ROLL TSIVIIL- JA KAITSEVALDKONNA KOOSTÖÖS NING INFOVAHETUSES
Creators: name: Koort, Erkki
Publisher: name: The Estonian Journal of Military Studies
Year: 2024

description: More than ten years ago the comprehensive defense concept was introduced in Estonia. This article analyses the learning experiences gained from three civil-military cooperation (CIMIC) operations with an emphasis on information exchange. Two out of the three were accidents and the third operation was staged, with all participants well aware of it several years in advance. The first CIMIC operation was carried out during an accident in Lake Ülemiste, where an aircraft landed on the frozen lake. The lake is right next to the Tallinn Airport and is also a water reservoir of the capital of Estonia. The second crisis situation happened in northeastern Estonia where extreme weather conditions blocked one of the key highways with more than 200 cars with 600 persons stuck in snow overnight. The third operation took place during the transport of euro banknotes and coins when euro was introduced as an official currency in Estonia. There were three key questions: 1) How organisations used lessons learned after the crisis, how they documented it and how they shared conclusions? 2) How the learning experience regarding crisis management was shared with partners and how organisations prepared together for future crisis situations? 3) Did civil-military cooperation go well during the three crisis situations?
description: The Estonian Journal of Military Studies, No. 15 (2020)
The street cost of drugs and drug use patterns : relationships with sex work income in an urban Canadian setting.
Creators: name: Deering, Kathleen N.
name: Shoveller, Jean
name: Tyndall, Mark
name: Montaner, Julio
name: Shannon, K.
Publisher: name: The University of British Columbia
Year: 2017

description: BACKGROUND: This study investigated the relationship between drug use and sex work patterns and sex work income earned among street-based female sex workers (FSWs) in Vancouver, Canada. METHODS: We used data from a sample of 129 FSWs who used drugs in a prospective cohort (2007-2008), for a total of 210 observations. Bivariate and multivariable linear regression using generalized estimating equations was used to model the relationship between explanatory factors and sex work income. Sex work income was log-transformed to account for skewed data. RESULTS: The median age of the sample at first visit was 37 years (interquartile range[IQR]: 30-43), with 46.5% identifying as Caucasian, 48.1% as Aboriginal and 5.4% as another visible minority. The median weekly sex work income and amount spent on drugs was $300 (IQR=$100-$560) and $400 (IQR=$150-$780), respectively. In multivariable analysis, for a 10% increase in money spent on drugs, sex work income increased by 1.9% (coeff: 0.20, 95% CIs: 0.04-0.36). FSWs who injected heroin, FSWs with higher numbers of clients and youth compared to older women (<25 versus 25+ years) also had significantly higher sex work income. CONCLUSIONS: This study highlights the important role that drug use plays in contributing to increased dependency on sex work for income among street-based FSWs in an urban Canadian setting, including a positive dose-response relationship between money spent on drugs and sex work income. These findings indicate a crucial need to scale up access and availability of evidence-based harm reduction and treatment approaches, including policy reforms, improved social support and economic choice for vulnerable women.
title: SIDI DAOUD
title: SIDI DAOUD
title: Atlas archéologique de la Tunisie
Creators: name: Babelon, Ernest Charles François
name: Babelon, Ernest Charles François > Auteur
name: Cagnat, René Louis Victor > Auteur
name: Reinach, Salomon > Auteur
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: subject: Archéologie
subject: Antiquité
subject: Recherche archéologique
subject: Savoirs (Les)
subject: Cartographie
subject: Atlas
subject: Atlas archéologique

description: [Atlas archéologique de la Tunisie ; Edition spéciale des cartes topographiques publiées par la ministère de la Guerre, accompagnée d’un texte explicatif rédigé par E. Babelon, R. Cagnat et S. Reinach, membres de la Commission de l’Afrique du Nord (1ère série, 60 feuilles au 1/50 000 et notices)]
description: Atlas
description: Atlas-Archeo-Tunisie_009
description: 1/50 000
description: La Méditerranée à la carte
description: Paris
description: Source: Institut de recherche sur le Maghreb contemporain (IRMC); Cité numérique de la Méditerranée (MMSH)
description: Source: La Méditerranée à la carte
description: Source: La Méditerranée à la carte > Atlas archéologique de la Tunisie
description: Relation: https://cinumed.mmsh.univ-aix.fr/idurl/1/96189
description: Coverage: Sidi Daoud
description: Coverage: Tunisie
description: Coverage: Antiquité
description: Temporal: Antiquité
description: Provenance: Institut de recherche sur le Maghreb contemporain (IRMC); Cité numérique de la Méditerranée (MMSH)