cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
MPEC 2024-V73 : 2024 VG1
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 VG1

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
title: Lesiones Traumáticas de la Aorta; A Propósito de un Caso.
Creators: name: Fernández Quintero, Rosa Mª
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Trauma
subject: CT-Angiography
subject: Arteries / Aorta

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Conocer la etiología,
fisiopatología,clínica,
semiología radiológica ypronóstico de las lesiones (daño)agudas traumáticas de la aorta torácica (DATA). Conocer el papel del/la radiólogo/a en esta patología como parte fundamental en el...
Multiple Active Compounds from Viscum album L. Synergistically Converge to Promote Apoptosis in Ewing Sarcoma
Creators: name: Twardziok, Monika
name: Kleinsimon, Susann
name: Rolff, Jana
name: Jaeger, Sebastian
name: Eggert, Angelika
name: Seifert, Georg
name: Delebinski, Catharina I.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 500 Naturwissenschaften und Mathematik::500 Naturwissenschaften
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Ewing sarcoma is the second most common bone cancer in children and adolescents, with poor prognosis and outcome in ~70% of initial diagnoses and 10–15% of relapses. Hydrophobic triterpene acids and hydrophilic lectins and viscotoxins from European mistletoe (Viscum album L.) demonstrate anticancer properties, but have not yet been investigated for Ewing sarcoma. Commercial Viscum album L. extracts are aqueous, excluding the insoluble triterpenes. We recreated a total mistletoe effect by combining an aqueous extract (viscum) and a triterpene extract (TT) solubilized with cyclodextrins. Ewing sarcoma cells were treated with viscum, TT and viscumTT in vitro, ex vivo and in vivo. In vitro and ex vivo treatment of Ewing sarcoma cells with viscum inhibited proliferation and induced apoptosis in a dose-dependent fashion, while viscumTT combination treatment generated a synergistic effect. Apoptosis occurred via intrinsic and extrinsic apoptotic pathways, evidenced by activation of both CASP8 and CASP9. We show that viscumTT treatment shifts the balance of apoptotic regulatory proteins towards apoptosis, mainly via CLSPN, MCL1, BIRC5 and XIAP downregulation. ViscumTT also demonstrated strong antitumor activity in a cell line- and patient-derived mouse model, and may be considered an adjuvant therapy option for pediatric patients with Ewing sarcoma.
Galaxy and mass assembly (GAMA): The galaxy luminosity function within the cosmic web
Creators: name: Eardley, E.
name: Peacock, J. A.
name: McNaught-Roberts, T.
name: Heymans, C.
name: Norberg, P.
name: Alpaslan, M.
name: Baldry, I.
name: Bland-Hawthorn, J.
name: Brough, S.
name: Cluver, Michelle
name: Driver, S. P.
name: Farrow, D. J.
name: Liske, J.
name: Loveday, J.
name: Robotham, A. S. G.
Publisher: name: Swinburne
Year: 2024

description: We investigate the dependence of the galaxy luminosity function on geometric environment within the Galaxy And Mass Assembly (GAMA) survey. The tidal tensor prescription, based on the Hessian of the pseudo-gravitational potential, is used to classify the cosmic web and define the geometric environments: for a given smoothing scale, we classify every position of the surveyed region, 0.04 < z < 0.26, as either a void, a sheet, a filament or a knot. We consider how to choose appropriate thresholds in the eigenvalues of the Hessian in order to partition the galaxies approximately evenly between environments. We find a significant variation in the luminosity function of galaxies between different geometric environments; the normalization, characterized by φ* in a Schechter function fit, increases by an order of magnitude from voids to knots. The turnover magnitude, characterized by M*, brightens by approximately 0.5 mag from voids to knots. However, we show that the observed modulation can be entirely attributed to the indirect local-density dependence. We therefore find no evidence of a direct influence of the cosmic web on the galaxy luminosity function.
Centre stage: An investigation of the role of stage of illness in psychosocial interventions for Bipolar Disorder
Creators: name: Tremain, Hailey
Publisher: name: Swinburne
Year: 2024

description: Stage of illness is a novel construct within bipolar disorders research, with intuitive appeal in its potential to improve treatment, which is commonly inadequate. This project involved five studies which shed light on the role stage of illness has in individuals' treatment, in particular psychological interventions. This project adds incrementally to the underdeveloped understanding of how stage of illness influences the outcomes of psychosocial treatments for bipolar disorders, and provides core directions for future research such as improved conceptualisation, measurement and operationalisation. Further, this project offers important clinical implications, such as more nuanced treatment in the vein of precision psychiatry.
title: Fístulas espontáneas de LCR de la base del cráneo en el adulto: Poco frecuentes, pero importantes.
Creators: name: Cano Alonso, Raquel
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Seizure disorders
subject: Congenital
subject: Tissue characterisation
subject: Education
subject: CT
subject: MR
subject: Bones
subject: Neuroradiology brain

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Revisarla clasificación etiológica de las Fístulas de Líquido Cefalorraquídeo (FLCR). Orientar el grueso del trabajo hacia el análisis de las FLCR espontáneas (FLCRE) de la base del cráneo,
analizando los siguientes puntos: Subdivisiónendos...
Galaxy And Mass Assembly (GAMA) blended spectra catalogue: Strong galaxy-galaxy lens and occulting galaxy pair candidates
Creators: name: Holwerda, B. W.
name: Baldry, I. K.
name: Alpaslan, M.
name: Bauer, A.
name: Bland-Hawthorn, J.
name: Brough, S.
name: Brown, M. J.I.
name: Cluver, Michelle
name: Conselice, C.
name: Driver, S. P.
name: Hopkins, A. M.
name: Jones, D. H.
name: López-Sánchez, A. R.
name: Loveday, J.
name: Meyer, M. J.
name: Moffett, A.
Publisher: name: Swinburne
Year: 2024

description: We present the catalogue of blended galaxy spectra from the Galaxy And Mass Assembly (GAMA) survey. These are cases where light from two galaxies are significantly detected in a single GAMA fibre. Galaxy pairs identified from their blended spectrum fall into two principal classes: they are either strong lenses, a passive galaxy lensing an emission-line galaxy; or occulting galaxies, serendipitous overlaps of two galaxies, of any type. Blended spectra can thus be used to reliably identify strong lenses for follow-up observations (high-resolution imaging) and occulting pairs, especially those that are a late-type partly obscuring an early-type galaxy which are of interest for the study of dust content of spiral and irregular galaxies. The GAMA survey setup and its AUTOZ automated redshift determination were used to identify candidate blended galaxy spectra from the cross-correlation peaks. We identify 280 blended spectra with a minimum velocity separation of 600 km s-1, of which 104 are lens pair candidates, 71 emission-line-passive pairs, 78 are pairs of emission-line galaxies and 27 are pairs of galaxies with passive spectra. We have visually inspected the candidates in the Sloan Digital Sky Survey (SDSS) and Kilo Degree Survey (KiDS) images. Many blended objects are ellipticals with blue fuzz (Ef in our classification). These latter `Ef' classifications are candidates for possible strong lenses, massive ellipticals with an emission-line galaxy in one or more lensed images. The GAMA lens and occulting galaxy candidate samples are similar in size to those identified in the entire SDSS. This blended spectrum sample stands as a testament of the power of this highly complete, second-largest spectroscopic survey in existence and offers the possibility to expand e.g. strong gravitational lens surveys.
title: MIRC: implantación en Hospital de la Princesa
Creators: name: González, Saturnino
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Computer Applications-General
subject: PACS
subject: Computer applications

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
1.
Demostrar la utilidad del formato de archivo electrónico MIRC (Medical Imaging and Resource Center) para el archivo de casos interesantes (ACI) con objetivo docente: teaching files (TF) 2.- Ilustrar el caso concreto de su implementación en el...
Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain
Creators: name: Felsky, Daniel
name: Patrick, Ellis
name: Schneider, Julie A.
name: Mostafavi, Sara
name: Gaiteri, Chris
name: Patsopoulos, Nikolaos
name: Bennett, David A.
name: De Jager, Philip L.
Publisher: name: BioMed Central
Year: 2018

description: Background: The role of the innate immune system in Alzheimer’s disease (AD) and neurodegenerative disease susceptibility has recently been highlighted in genetic studies. However, we do not know whether risk for inflammatory disease predisposes unaffected individuals to late-life cognitive deficits or AD-related neuropathology. We investigated whether genetic risk scores for seven immune diseases and central nervous system traits were related to cognitive decline (nmax = 1601), classical AD neuropathology (nmax = 985), or microglial density (nmax = 184). Methods: Longitudinal cognitive decline, postmortem amyloid and tau neuropathology, microglial density, and gene module expression from bulk brain tissue were all measured in participants from two large cohorts (the Rush Religious Orders Study and Memory and Aging Project; ROS/MAP) of elderly subjects (mean age at entry 78 +/− 8.7 years). We analyzed data primarily using robust regression methods. Neuropathologists were blind to clinical data. Results: The AD genetic risk scores, including and excluding APOE effects, were strongly associated with cognitive decline in all domains (min Puncor = 3.2 × 10− 29). Multiple sclerosis (MS), Parkinson’s disease, and schizophrenia risk did not influence cognitive decline in older age, but the rheumatoid arthritis (RA) risk score alone was significantly associated with microglial density after correction (t146 = − 3.88, Puncor = 1.6 × 10− 4). Post-hoc tests found significant effects of the RA genetic risk score in multiple regions and stages of microglial activation (min Puncor = 1.5 × 10− 6). However, these associations were driven by only one or two variants, rather than cumulative polygenicity. Further, individual MS (Pone-sided < 8.4 × 10− 4) and RA (Pone-sided = 3 × 10− 4) variants associated with higher microglial density were also associated with increased expression of brain immune gene modules. Conclusions: Our results demonstrate that global risk of inflammatory disease does not strongly influence aging-related cognitive decline but that susceptibility variants that influence peripheral immune function also alter microglial density and immune gene expression in the aging brain, opening a new perspective on the control of microglial and immune responses within the central nervous system. Further study on the molecular mechanisms of peripheral immune disease risk influencing glial cell activation will be required to identify key regulators of these pathways.
title: Coartación Aórtica en el adulto. Qué datos debemos aportar en la RM para el Tratamiento Endovascular.
Creators: name: de Araujo Martins Romeo, Daniela
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: MR-Angiography
subject: MR
subject: Vascular
subject: Cardiovascular system
subject: Arteries / Aorta

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Aspectos diagnósticos : Se incide en el diagnóstico y en la patología asociada. Aspectos funcionales : Cómo y dónde debemos obtener datos para estimar la severidad de la Coartación Aórtica (CoA). Aspectos morfológicos : Se hace hincapié en...
title: HEMOCROMATOSIS : Hallazgos Típicos y Atípicos en Resonancia Magnética de Hígado
Creators: name: Alvarado Rosas, Jose Armando
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Abdomen
subject: MR
subject: Liver

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Revisar la utilidad clínica y diagnóstica de la resonancia magnética de hígado en el estudio de la hemocromatosis. Ilustrar los diferentes hallazgos típicos y atípicos de la hemocromatosis en resonancia magnética de...
Experience at the edge: Immediate experience and the given in twentieth-century Anglo-American philosophy.
Creators: name: Fortier, Evlyn.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Philosophy.

description: This thesis is an exploration of the idea of immediate experience. Three questions are asked: is there Immediate experience, what is immediate experience and what use is immediate experience. These questions are posed in the course of surveying the recent history of immediate experience with a view to rehabilitating it as a means of solving a particular philosophical problem. This problem is the paradox resulting from the fact that knowledge both depends on a dichotomy of 'knowing' and 'object known' (mind and world) and yet is vitiated by it. A synopsis of approaches to the problem of the dichotomy of mind and world is presented and claims about experience in relation to the paradox are examined. Then it is proposed that we should reconsider the theory of immediate experience, incorporating the idea that experience is already conceptually informed. This results in a theory of immediate experience that is conceptualizable, that is constituted of thinkable contents Immediate experience avoids the problems of dualism because it does not involve a dichotomy of mind and world. But once experience is conceptualized into ordinary, discursive experience, it involves a dichotomy so that knowledge is 'knowledge about.' By dissolving the paradox, immediate experience offers a better explanation than a dualistic account. And since immediate experience is conceptualizable, we avoid the criticism that there is no experience without interpretation or a conceptual framework in place.
title: Cirugía Bariátrica: El Radiólogo a la Caza de Fugas.
Creators: name: Pérez Durán, Arlene
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Contrast agent-oral
subject: Contrast agent-intravenous
subject: CT
subject: Fluoroscopy
subject: Stomach (incl. Oesophagus)
subject: Abdomen

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
La obesidad es una enfermedad crónica multifactorial con importante afectación social,
psicológica y económica,
que se está convirtiendo en una epidemia mundial con mayor prevalencia en los paises occidentales.Se asocia a múltiples...
Formation and characterization of solvent resistant nanofiltration membranes
Creators: name: Wijaya, Julie E
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Engineering, Chemical.

description: In this work, a novel approach for preparing nanofiltration membranes using poly(amide imide) (TorlonRTM)/Chitosan composites by coating the Chitosan solution on top of the Torlon base membrane and subsequently curing and neutralization with sodium bicarbonate (NaHCO3) has been developed. In general, TorlonRTM/Chitosan composite nanofiltration membranes were found to be stable in aqueous medium and when contacted with the solvents. A uniform Chitosan dense layer was successfully coated on the base membrane, which reduced the effect of chemical degradation of the membrane. Low permeability of solvents was attributed to the swelling of the Torlon RTM layer. It is proposed that by increasing the porosity in the TorlonRTM based membrane or utilizing other polymers which contain amide chains as the support membrane, permeability performance could be enhanced. (Abstract shortened by UMI.)
Outdoor education programs as gender equitable environments? An ethnographic study.
Creators: name: Monsour, Katrina L.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Education, Physical.

description: Many physical education researchers have been searching for gender equitable physical education programs. The purpose of this ethnographic study was to examine the issue of gender equity in one outdoor education program. More specifically, the study focused on the perspectives and behaviours of 10 young women and 14 young men with respect to gender relations and gender equity in one outdoor education program. Qualitative and triangulated data collection methods were used, namely; (a) a content analysis of official outdoor education program documents; (b) a non-participant observation of program participants and their counsellors; and (c) a semi-structured, small, single-sex group interviews with program participants. The program documents were collected in June of 1996 and then content analysed. The observations and interviews took place during the last five days of a 12-day outdoor education camp. The recorded interactional episodes, and the tape recorded interviews were transcribed onto a word processor, content analysed, and patterns with regards to gender relations and gender equity/inequity emerged. From the results, two main conclusions could be drawn. First, the young women and young men at the outdoor education camp displayed some traditional stereotypical attitudes and behaviours that produced oppressive gender relations and contributed to a learning environment that was not gender equitable. Second, the campers also demonstrated attitudes and involved themselves in behaviours that challenged traditional gender relations and promoted gender equity.
title: Habemus TEP.y ahora que?
Creators: name: Barranco Pons, Roger
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Embolism / Thrombosis
subject: Obstruction / Occlusion
subject: Decision analysis
subject: Recanalisation
subject: Thrombolysis
subject: Catheter arteriography
subject: CT-Angiography
subject: Percutaneous
subject: Interventional vascular
subject: Pulmonary vessels

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Revisar la bibliografía para crear el protocolo del hospital e intentar convenzer a nuestros especialistas para que crean en el tratamiento endovascular del tromboembolismo pulmonar y así deriven los casos...
Integrating morphological characters, molecular markers, and distribution patterns to assess the identity of Blepharis species from Jordan
Creators: name: Muhaidat, Riyadh
name: Brake, Mohammad H
name: Al Zoubi, Mazhar
name: Colautti, Robert I
name: Al-Nasser, Amjad
name: Awawdeh, Muheeb
name: Al-Batayneh, Khalid
name: Al Khateeb, Wesam
name: McKown, Athena D
name: Lahham, Jamil
name: El-Oqlah, Ahmad
Publisher: name: Springer Berlin Heidelberg
Year: 2018

description: Background: Blepharis constitutes an important part of the vegetation of the Jordanian arid and semi-arid regions, yet whether one or more species of this genus occurs in the Jordanian area is uncertain. We addressed this question by assessing morphological characters and testing Inter-Simple Sequence Repeat (ISSR) markers from three populations of Blepharis: two northern (lower slopes of Kufranjah valley and the Dead Sea region) and one southern (Wadi al Yutm). Results: Shoots from randomly chosen Blepharis plants were harvested from each of the three populations for morphological and molecular analyses. In the northern populations, spikes were lax and bract width was significantly shorter than length of the longest lateral spine compared to the southern population. A multivariate linear discriminant analysis distinguished the northern populations from the southern one by internode length, bract width, longest lateral spine length, and bract width to spine length ratio. The ISSR analysis revealed that 44 markers across eight primers were polymorphic with major allele frequency of 83.6% and an average of 5.5 polymorphic markers per primer. The genetic resemblance among individuals ranged from 0.27 to 0.96. The three Blepharis populations were accordingly clustered into two distinct groups, similar to the analysis of morphological differences and corresponding with the “northern” and “southern” population designations. Conclusions: Our results strongly indicate the occurrence of two discrete Blepharis species in Jordan and reject the hypothesis that the genus is represented by only one species. We propose that the Blepharis species in Jordan are B. attenutata Napper (represented by the northern populations) and B. ciliaris (L.) B. L. Burtt (represented by the southern population). These findings are important for informing and revising floristic work within the region and an updated key has been included in our findings.
Galaxy And Mass Assembly (GAMA): The effect of close interactions on star formation in galaxies
Creators: name: Davies, L. J.M.
name: Robotham, A. S. G.
name: Driver, S. P.
name: Alpaslan, M.
name: Baldry, I. K.
name: Bland-Hawthorn, J.
name: Brough, S.
name: Brown, M. J. I.
name: Cluver, Michelle
name: Drinkwater, M. J.
name: Foster, C.
name: Grootes, M. W.
name: Konstantopoulos, I. S.
name: Lara-López, M. A.
name: Lopez-Sanchez, R.
name: Loveday, J.
name: Meyer, M. J.
name: Moffett, A. J.
name: Norberg, P.
name: Owers, M. S.
name: Popescu, C. C.
name: De Propris, R.
name: Sharp, R.
name: Tuffs, R. J.
name: Wang, L.
name: Wilkins, S. M.
name: Dunne, L.
name: Bourne, N.
name: Smith, M. W.L.
Publisher: name: Swinburne
Year: 2024

description: The modification of star formation (SF) in galaxy interactions is a complex process, with SF observed to be both enhanced in major mergers and suppressed in minor pair interactions. Such changes likely to arise on short time-scales and be directly related to the galaxy-galaxy interaction time. Here we investigate the link between dynamical phase and direct measures of SF on different time-scales for pair galaxies, targeting numerous star- formation rate (SFR) indicators and comparing to pair separation, individual galaxy mass and pair mass ratio. We split our sample into the higher (primary) and lower (secondary) mass galaxies in each pair and find that SF is indeed enhanced in all primary galaxies but suppressed in secondaries of minor mergers. We find that changes in SF of primaries are consistent in both major and minor mergers, suggesting that SF in the more massive galaxy is agnostic to pair mass ratio. We also find that SF is enhanced/suppressed more strongly for short-duration SFR indicators (e.g. Hα), highlighting recent changes to SF in these galaxies, which are likely to be induced by the interaction. We propose a scenario where the lower mass galaxy has its SF suppressed by gas heating or stripping, while the higher mass galaxy has its SF enhanced, potentially by tidal gas turbulence and shocks. This is consistent with the seemingly contradictory observations for both SF suppression and enhancement in close pairs.
title: Hormonal contraceptives and risk of ischemic stroke in women with migraine
title: a consensus statement from the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESC)
titleType: Subtitle
Creators: name: Sacco, Simona
name: Merki-Feld, Gabriele S.
name: Aegidius, Karen Lehrmann
name: Bitzer, Johannes
name: Canonico, Marianne
name: Kurth, Tobias
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Migraine
subject: Aura
subject: Headache
subject: Stroke
subject: Hormonal contraceptives
subject: Contraception
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Several data indicate that migraine, especially migraine with aura, is associated with an increased risk of ischemic stroke and other vascular events. Of concern is whether the risk of ischemic stroke in migraineurs is magnified by the use of hormonal contraceptives. As migraine prevalence is high in women of reproductive age, it is common to face the issue of migraine and hormonal contraceptive use in clinical practice. In this document, we systematically reviewed data about the association between migraine, ischemic stroke and hormonal contraceptive use. Thereafter a consensus procedure among international experts was done to develop statements to support clinical decision making, in terms of cardiovascular safety, for prescription of hormonal contraceptives to women with migraine. Overall, quality of current evidence regarding the risk of ischemic stroke in migraineurs associated with the use of hormonal contraceptives is low. Available data suggest that combined hormonal contraceptive may further increase the risk of ischemic stroke in those who have migraine, specifically migraine with aura. Thus, our current statements privilege safety and provide several suggestions to try to avoid possible risks. As the quality of available data is poor further research is needed on this topic to increase safe use of hormonal contraceptives in women with migraine.
Herpetosin A, a nor-cucurbitane triterpenoid with a 5/6/6/5 ring system from Herpetospermum pedunculosum
Creators: name: Chen, Qianyu
name: Ma, Yingxiong
name: Dong, Zhaoyue
name: Xu, Bing
name: Wang, Guowei
name: Lan, Xiaozhong
name: Liao, Zhihua
name: Chen, Min
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Two previously undescribed triterpenoids, herpetosin A (1) and herpetosin B (2), together with two known compounds, cucurbitacin B (3) and dihydrocucurbitacin E (4), were isolated from the seeds of Herpetospermum pedunculosum. Their structures were elucidated by analysis of the NMR, HR-ESI-MS, X-ray data and quantum chemical calculation. Compound 1 featured an unprecedented nor-cucurbitane triterpenoid skeleton with a 5/6/6/5 ring system. Among all the isolates, compound 4 exhibited anti-proliferative effect with IC50 values of 4.5 ± 0.1 μM against A549 cells, 8.2 ± 0.5 μM against MDA-MB-231 cells, and 2.4 ± 0.3 μM against HepG2 cells, respectively.
Presenting a prototype platform for mapping epidemiological cohort metadata with environmental and earth observation metadata: the MetaMap³ project
Creators: name: Wolf, Kathrin
name: Dallavalle, Marco
name: Gey, Ronny
name: Staab, Jeroen
name: Standl, Marie
name: Bumberger, Jan
name: Taubenböck, Hannes
Publisher: name: Zenodo
Year: 2024
Subjects: subject: Public health
subject: environment
subject: earth observation
subject: metadata mapping
subject: metadata catalog

description: Introduction: The environment plays an important role for human health and efficient linkage of epidemiological cohorts with environmental data is crucial to quantify human exposures. However, there are no harmonized standards for automatic mapping of metadata of our three domains Health (HMGU), Earth & Environment (UFZ), and Aeronautics, Space & Transport (DLR).

Objective: We aimed to ease the search for appropriate exposure data for subsequent epidemiological analyses by generating and enriching interoperable and machine-readable metadata for exemplar cohort and exposure data and by mapping these metadata so that they can be jointly queried and searched.

Methods: Our use case for cohort metadata consisted of the two German prospective, population-based birth cohorts GINIplus and LISAplus which were conducted in four study regions across Germany and included up to seven examination rounds since 1995. As use cases for environmental data, we considered land cover classification available for a single time point (06/2015-09/2017 mean) and daily soil moisture index data for the entire study period. Since both factors influence air temperature, they are of specific interest when investigating the effects of temperature extremes on human health. We reviewed several standards, strategies and tools and developed an approach to align the heterogenous metadata to a common structure and format.

Results: We identified spatial and temporal coverage as the main mapping criteria. For the environmental metadata and the epidemiological metadata that have a spatial component (study centers, recruitment districts) we converged to the international standard for geographic information ISO 19115 and to the eXtensible Markup Language (XML). Based on our conceptual work, we identified the catalog application GeoNetwork as the best tool for our application.  After setting up a test instance on a local server for our use cases metadata, the catalog can now be accessed at https://envepi.helmholtz-munich.de/geonetwork/.

Discussion: We are continuously populating the mapping platform with further metadata. Also, we are currently testing the full functionality of the tool, especially the filtering and search options of the application to enable the intended mapping.

 

This work was funded by the Helmholtz Association’s Initiative and Networking Fund (INF): ZT-I-PF-3-018
La surveillance électronique et le pénal.
Creators: name: Ouellet, Denis.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Sociology, Criminology and Penology.

description: Qu'est-ce que la surveillance electronique? Utilisee comme ajout aux programmes de mise en liberte avant proces, de probation, de probation supervision intensive, de liberation conditionnelle et d'absences temporaires, cette surveillance permettrait, tout en surveillant intensivement le condamne, d'abaisser la surpopulation penale, les couts engendres par l'incarceration, d'augmenter la securite publique et de favoriser la rehabilitation des condamnes. Est-ce vraiment le cas? Selon certains auteurs, il est evident que la surveillance electronique est une nouveaute qui atteint ces objectifs. Mais lorsqu'on regarde de plus pres, il est possible de constater que ce nouveau type de surveillance n'atteint pas ces objectifs. Toujours sous le signe de la nouveaute technique, la surveillance electronique est plutot, tout comme le panopticon de Bentham fut au XVIIIieme siecle, une surveillance qui permet un pouvoir simple, interiorise, economique et extensif qui engendre chez le condamne une auto-observation qui se manifeste par l'interiorisation d'une discipline et des regles.
Somatostatin, neuropeptide Y and galanin: Immunohistochemical detection and mapping of neuropeptide distributions in goldfish brain, with reference to rat.
Creators: name: Pickavance, Lucy Cecilia.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Biology, Neuroscience.

description: The biochemical neuroanatomy of the goldfish brain, with some reference to that in the rat brain, was investigated. Retrograde tracing immunofluorescence techniques reveal that the efferents of the somatostatin (SRIF)-positive cells of the entopeduncular nucleus of the rat do not project to the ventroanterior/ventrolateral nuclei of the thalamus. Using of immunohistochemical staining techniques, the distributions of the neurotransmitters SRIF, NPY and galanin (Gal) were mapped throughout the brain of the goldfish. Single-label immunohistochemistry was used to determine the distribution of Gal in the goldfish brain. Gal is present primarily in fibres and terminals but in only a few cell bodies restricted to the preoptic and tuberal hypothalamus and the reticular formation. When the distributions of SRIF, NPY and Gal in the goldfish brain were compared to the literature on brains of other teleost fish and in the mammalian brain, it was clear that they have altered little across species. (Abstract shortened by UMI.)
X-ray emission from the taffy (VV254) galaxies and bridge
Creators: name: Appleton, P. N.
name: Lanz, L.
name: Bitsakis, T.
name: Wang, J.
name: Peterson, B. W.
name: Lisenfeld, U.
name: Alatalo, K.
name: Guillard, P.
name: Boulanger, F.
name: Cluver, Michelle
name: Gao, Y.
name: Helou, G.
name: Ogle, P.
name: Struck, C.
Publisher: name: Swinburne
Year: 2024

description: We present the first X-ray observations of the Taffy galaxies (UGC 12914/5) with the Chandra observatory and detect soft X-ray emission in the region of the gas-rich, radio-continuum-emitting Taffy bridge. The results are compared to Herschel observations of dust and diffuse [C ii] line-emitting gas. The diffuse component of the Taffy bridge has an X-ray luminosity of {L}{{X}(0.5-8 {keV})} = 5.4 × 1039 erg s-1, which accounts for 19% of the luminosity of the sum for the two galaxies. The total mass in hot gas is (0.8-1.3) × 108 M⊙, which is approximately 1% of the total (H i + H2) gas mass in the bridge, and ˜11% of the mass of warm molecular hydrogen discovered by Spitzer. The soft X-ray and dense CO-emitting gas in the bridge have offset distributions, with the X-rays peaking along the northwestern side of the bridge in the region where stronger far-IR dust and diffuse [C ii] gas is observed by Herschel. We detect nine Ultra Luminous X-ray sources in the system, the brightest of which is found in the bridge, associated with an extragalactic H ii region. We suggest that the X-ray-emitting gas has been shocked—heated to high temperatures and “splashed” into the bridge by the collision. The large amount of gas stripped from the galaxies into the bridge and its very long gas depletion timescale (>10 Gyr) may explain why this system, unlike most major mergers, is not a powerful IR emitter.
Open versus arthroscopic Latarjet procedures for the treatment of shoulder instability: a systematic review of comparative studies
Creators: name: Horner, Nolan S
name: Moroz, Paul A
name: Bhullar, Raman
name: Habib, Anthony
name: Simunovic, Nicole
name: Wong, Ivan
name: Bedi, Asheesh
name: Ayeni, Olufemi R
Publisher: name: BioMed Central
Year: 2018

description: Background: The arthroscopic and open Latarjet procedures are both known to successfully treat shoulder instability with high success rates. The objective of this study was to compare the clinical outcomes and positioning of the coracoid graft and screws between the arthroscopic and open Latarjet procedures. Methods: The electronic databases MEDLINE, EMBASE, and PubMed were searched for relevant studies between database creation and 2018. Only studies directly comparing open and arthroscopic Latarjet procedures were included. Results: There were 8 included studies, with a total of 580 patients treated arthroscopically and 362 patients treated with an open Latarjet procedure. Several papers found significantly better standardized outcome scores for either the open or arthroscopic procedure but these findings were not consistent across papers. Patients treated with arthroscopic Latarjet procedures had significantly lower initial post-operative pain, however pain scores became equivalent by one month post-operatively. Three of the five included studies found no significant difference in the coracoid graft positioning and two of three included studies found no significant difference in screw divergence angles between the two techniques. Arthroscopic procedures (112.2 min) appear to take, on average, longer than open procedures (93.3 min). However, operative times and complication rates decrease with surgeon experience with the arthroscopic procedure. Overall 3.8% of the patients treated arthroscopically and 6.4% of the patients treated with the open procedure went on to have post-operative complications. Conclusions: Both open and arthroscopic Latarjet procedures can be used to effectively treat shoulder instability with similarly low rates of complications, recurrent instability and need for revision surgery. Arthroscopic Latarjet procedures are associated with less early post-operative pain but require increased operative time. The evidence does not support there being any significant difference in graft or screw positioning between the two techniques. At this time neither procedure shows clear superiority over the other.
Sample compression, margins and generalization: Extensions to the set covering machine
Creators: name: Shah, Mohak
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Computer Science.

description: This thesis studies the generalization behavior of algorithms in Sample Compression Settings. It extends the study of the Sample Compression framework to derive data-dependent bounds that give tighter guarantees to the algorithms where data-independent bounds such as the VC bounds are not applicable. It also studies the interplay between sparsity and the separating margin, of the classifier and shows how new compression based data-dependent bounds can be obtained that can exploit these two quantities explicitly. These bounds not only provide tight generalization guarantees but by themselves present optimization problems for learning leading to novel learning algorithms. This thesis studies the algorithms based on learning conjunctions or disjunctions of data-dependent Boolean features. With the Set Covering Machine (SCM) as its basis, the thesis shows how novel learning algorithms can be designed in compression settings that can perform a non-trivial margin-sparsity trade-off to yield better classifiers. Moreover, the thesis also shows how feature-selection can be integrated with the learning process in these settings yielding algorithms that not only perform successful feature selection but also have provable theoretical guarantees. In particular, the thesis proposes two novel learning algorithms. The first algorithm is for the SCM with data-dependent half-spaces along with a tight compression bound that can successfully perform model selection. The second algorithm aims at learning conjunctions of features called data-dependent Rays to classify gene expression data from DNA microarrays. The thesis shows how a PAC-Bayes approach to learning Rays' conjunctions can perform a non-trivial margin-sparsity trade-off to achieve classifiers that not only have provable theoretical guarantees but also utilize a significantly small number of attributes unlike traditional feature selection algorithms. This thesis also proposes two new formulations for the classical SCM algorithm with data-dependent balls aimed at performing margin-sparsity trade-off by utilizing Occam's Razor and PAC-Bayes principles respectively. The thesis shows how such approaches yield more general classifiers with tight risk bounds that can potentially guide the model selection process.
Galaxy And Mass Assembly (GAMA): Growing up in a bad neighbourhood - how do low-mass galaxies become passive?
Creators: name: Davies, L. J.M.
name: Robotham, A. S.G.
name: Driver, S. P.
name: Alpaslan, M.
name: Baldry, I. K.
name: Bland-Hawthorn, J.
name: Brough, S.
name: Brown, M. J.I.
name: Cluver, Michelle
name: Holwerda, B. W.
name: Hopkins, A. M.
name: Lara-López, M. A.
name: Mahajan, S.
name: Moffett, A. J.
name: Owers, M. S.
name: Phillipps, S.
Publisher: name: Swinburne
Year: 2024

description: Both theoretical predictions and observations of the very nearby Universe suggest that low-mass galaxies(log10[M*/M⊙] < 9.5) are likely to remain star-forming unless they are affected by their local environment. To test this premise, we compare and contrast the local environment of both passive and star-forming galaxies as a function of stellar mass, using the Galaxy and Mass Assembly survey. We find that passive fractions are higher in both interacting pair and group galaxies than the field at all stellar masses, and that this effect is most apparent in the lowest mass galaxies. We also find that essentially all passive log10[M*/M⊙] < 8.5 galaxies are found in pair/group environments, suggesting that local interactions with a more massive neighbour cause them to cease forming new stars. We find that the effects of immediate environment (local galaxy-galaxy interactions) in forming passive systems increase with decreasing stellar mass, and highlight that this is potentially due to increasing interaction time-scales giving sufficient time for the galaxy to become passive via starvation. We then present a simplistic model to test this premise, and show that given our speculative assumptions, it is consistent with our observed results.
L'intégration des jeunes de Montréal-Nord: Tradition ou modernité?
Creators: name: Audy, Émilie F
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Canadian Studies.
subject: Sociology, Social Structure and Development.

description: Cette thèse est la rencontre des résultats d'une enquête portant sur l'intégration des jeunes à la société québécoise et l'approche fonctionnaliste des divers acteurs sociaux facilitant cette intégration. Au cours de la dernière année, nous avons travaille des données quantitatives recueillies auprès de 200 jeunes de Montréal-Nord ainsi que différentes théories sociologiques afin de déterminer comment les jeunes réussissaient à s'intégrer à la société québécoise. Nous cherchions d'une part, à savoir quels types d'institutions venaient en aide aux jeunes lors de leurs processus d'intégration. Est-ce des institutions traditionnelles telles que la famille, ou au contraire, des institutions modernes telles que l'école et les groupes de pairs? Nous cherchions d'abord à déterminer quel était le rôle exact de la famille, ainsi que le rôle de l'éducation et des groupes de pairs dans l'intégration des jeunes. Bien que les valeurs défendues par la famille entrent souvent en conflit avec les valeurs promues par la sous-culture de la jeunesse, nos recherches ont démontré que de telles rivalités étaient nécessaires à l'intégration et à la formation de l'identité du jeune. Ainsi, la famille et les groupes de pairs ne sont pas des institutions rivales, mais bien complémentaires et fondamentales pour la socialisation du jeune. Cette question a été posée à 3 groupes de jeunes, à savoir les immigrants, les immigrants de deuxième génération et les québécois de souche. Nos résultats nous ont démontré qu'il n'y avait pas de différence dans le processus d'intégration de nos trois groupes. Ainsi, il serait faux d'affirmer que les jeunes immigrants ont plus de difficulté à s'adapter et s'intégrer à la société québécoise que leur camarade de classe québécois.
Reconceptualising Psychopathy
Creators: name: Mihailides, Stephen Peter
Publisher: name: Swinburne
Year: 2024

description: Psychopathy was reconceptualised for the normal range, emphasising its relevance universally. Meta-ethics was applied to place psychopathy as centrally relevant in genocide, war crimes, and where its presence underscored justification for particular laws. As such psychopathy and empathy are not mutually exclusive, and implications of this as they impact child rearing were included in the four-Journal experimental series. Theory was grounded in Evolutuionary Psychology. A new methodology, the Moral Inversion Method, combined idiographic and nomothetic processes. The psychopathy induction was developed to measure psychopathy's footprint, trans-culturally. Experimental induction returned data underscoring the urgency to formulate means that inform new ways to approach means to quell genocide onset.
Auswirkungen des Klimawandels auf wasserbürtige Infektionen und Intoxikationen
Creators: name: Dupke, Susann
name: Buchholz, Udo
name: Fastner, Jutta
name: Förster, Christina
name: Selinka, Hans-Christoph
Publisher: name: My University
Year: 2023

description: Der fortschreitende Klimawandel birgt das Potenzial für eine zunehmende menschliche Gesundheitsgefährdung durch wasserbürtige Infektionen und Intoxikationen, z. B. durch eine Erhöhung von Pathogenkonzentrationen in Gewässern, durch die Ansiedlung neuer Pathogene oder durch mögliche Veränderungen von Erregereigenschaften. Dieser Beitrag stellt exemplarisch einige Beispiele für mögliche Auswirkungen des Klimawandels dar. Nicht-Cholera-Vibrionen kommen natürlicherweise im Meerwasser vor, können sich aber in flachem Wasser bei erhöhter Temperatur erheblich vermehren. Im Falle von Legionellen könnten die Klimaveränderungen durch das Zusammenwirken von warmem und feuchtem Wetter zu temporären oder längerfristig erhöhten Legionellose-Inzidenzen führen. Auch könnten durch wärmeres Kaltwasser oder Senkungen der Temperatur des Warmwassers Bedingungen entstehen, die höheren Legionellenkonzentrationen Vorschub leisten. In nährstoffreichen Gewässern kann es bei Temperatursteigerung zu erhöhten Konzentrationen an toxigenen Cyanobakterien kommen. Durch Starkregenfälle nach Stürmen oder längeren Hitzeperioden mit Trockenheit können humanpathogene Viren vermehrt in Gewässer eingeschwemmt werden. Und auch bei Erregern von Mykosen und fakultativ pathogenen Mikroorganismen besteht bei steigenden Temperaturen eine mögliche Gefährdung für die menschliche Gesundheit. So wurden nach Extremwetterereignissen bereits erhöhte Infektionsraten mit nicht-tuberkulösen Mykobakterien oder Pilzen dokumentiert. Quelle: Dupke S, Buchholz U, Fastner J, Förster C, Frank C et al. (2023): Auswirkungen des Klimawandels auf wasserbürtigeInfektionen und Intoxikationen. J Health Monit 8(S3): Seite 67