cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Ligand-Specific Factors Influencing GLP-1 Receptor Post-Endocytic Trafficking and Degradation in Pancreatic Beta Cells
Creators: name: Fang, Zijian
name: Chen, Shiqian
name: Manchanda, Yusman
name: Bitsi, Stavroula
name: Pickford, Philip
name: David, Alessia
name: Shchepinova, Maria M.
name: Corrêa Jr, Ivan R.
name: Hodson, David J.
name: Broichhagen, Johannes
name: Tate, Edward W.
name: Reimann, Frank
name: Salem, Victoria
name: Rutter, Guy A.
name: Tan, Tricia
name: Bloom, Stephen R.
name: Tomas, Alejandra
name: Jones, Ben
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: glucagon-like peptide-1
exendin-4
trafficking
biased agonism
degradation
endothelin converting enzyme-1

description: The glucagon-like peptide-1 receptor (GLP-1R) is an important regulator of blood glucose homeostasis. Ligand-specific differences in membrane trafficking of the GLP-1R influence its signalling properties and therapeutic potential in type 2 diabetes. Here, we have evaluated how different factors combine to control the post-endocytic trafficking of GLP-1R to recycling versus degradative pathways. Experiments were performed in primary islet cells, INS-1 832/3 clonal beta cells and HEK293 cells, using biorthogonal labelling of GLP-1R to determine its localisation and degradation after treatment with GLP-1, exendin-4 and several further GLP-1R agonist peptides. We also characterised the effect of a rare GLP1R coding variant, T149M, and the role of endosomal peptidase endothelin-converting enzyme-1 (ECE-1), in GLP1R trafficking. Our data reveal how treatment with GLP-1 versus exendin-4 is associated with preferential GLP-1R targeting towards a recycling pathway. GLP-1, but not exendin-4, is a substrate for ECE-1, and the resultant propensity to intra-endosomal degradation, in conjunction with differences in binding affinity, contributes to alterations in GLP-1R trafficking behaviours and degradation. The T149M GLP-1R variant shows reduced signalling and internalisation responses, which is likely to be due to disruption of the cytoplasmic region that couples to intracellular effectors. These observations provide insights into how ligand- and genotype-specific factors can influence GLP-1R trafficking.
Additional file 7 of Optical tissue measurements of invasive carcinoma and ductal carcinoma in situ for surgical guidance
Creators: name: De Boer, Lisanne L.
name: Kho, Esther
name: Van De Vijver, Koen K.
name: Marie-Jeanne T. F. D. Vranken Peeters
name: Van Duijnhoven, Frederieke
name: Hendriks, Benno H. W.
name: Sterenborg, Henricus J. C. M.
name: Ruers, Theo J. M.
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Plant Biology

description: Additional file 7. Results of the GEE analysis of all spectral features. The table lists all p-values of the spectral features from the GEE-analysis.
Irrigation adoption by orange producers of the state of São Paulo-Brazil: determinants and barriers
Creators: name: Rossi, Fabiana Ribeiro
name: Souza Filho, Hildo Meirelles De
name: Carrer, Marcelo Jose
name: Rossi, Fabiana Ribeiro
name: Souza Filho, Hildo Meirelles De
name: Carrer, Marcelo Jose
Publisher: name: Unknown
Year: 2016
Subjects: subject: Agribusiness
subject: Agricultural and Food Policy
subject: Farm Management
subject: Orange production
subject: Irrigation adoption
subject: determinants

description: Brazil is the larger producer of fresh oranges contributing with 55% of the world´s production. The state of São Paulo-Brazil produces more than 70% of Brazilian´s national fresh oranges production. In spite of the importance of the orange activity to the economy of Brazil, more than 70% of the orange producers abandoned the activity in São Paulo between 1995 and 2014 due mainly to considerable reduction in their profits. Adopting irrigation can lead to an increase in the production factor yields and, consequently, to a reduction on the production costs per orange box, restoring the producers’ profitability. This paper aims to identify and analyze the factors that influence the adoption of irrigation systems in orange orchards in São Paulo-Brazil by using descriptive statistics, hypothesis testing and a probit model. We identified that the number of oranges varieties grown in the property, the percentage of the total agricultural income obtained with the orange activity, the number of management tools used in the production system, the risk preference of the producer with respect to the orange commercialization, the experience of the producer in the agricultural activity and the amount of money spent with technical assistance impacted significantly the irrigation adoption.
Additional file 8 of Optical tissue measurements of invasive carcinoma and ductal carcinoma in situ for surgical guidance
Creators: name: De Boer, Lisanne L.
name: Kho, Esther
name: Van De Vijver, Koen K.
name: Marie-Jeanne T. F. D. Vranken Peeters
name: Van Duijnhoven, Frederieke
name: Hendriks, Benno H. W.
name: Sterenborg, Henricus J. C. M.
name: Ruers, Theo J. M.
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Plant Biology

description: Additional file 8. Selection of feature set with a floating search. The table lists the set of features that is selected after the floating feature search.
Poisson Structure and Moyal Quantisation of the Liouville Theory
Creators: name: Jorjadze, George
name: Weigt, Gerhard
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The symplectic and Poisson structures of the Liouville theory are derived from the symplectic form of the SL(2,R) WZNW theory by gauge invariant Hamiltonian reduction. Causal non-equal time Poisson brackets for a Liouville field are presented. Using the symmetries of the Liouville theory, symbols of chiral fields are constructed and their *-products calculated. Quantum deformations consistent with the canonical quantisation result, and a non-equal time commutator is given.
description: 32 pages, LaTeX, no figures
Optical spin locking of a solid-state qubit
Creators: name: Bodey, J. H.
name: Stockill, R.
name: Denning, E. V.
name: Gangloff, D. A.
name: Éthier-Majcher, G.
name: Jackson, D. M.
name: Clarke, E.
name: Hugues, M.
name: Gall, C. Le
name: Atatüre, M.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Article
/639/766/400/482
/639/766/483/2802
/639/301/119/1000/1017
article

description: Abstract: Quantum control of solid-state spin qubits typically involves pulses in the microwave domain, drawing from the well-developed toolbox of magnetic resonance spectroscopy. Driving a solid-state spin by optical means offers a high-speed alternative, which in the presence of limited spin coherence makes it the preferred approach for high-fidelity quantum control. Bringing the full versatility of magnetic spin resonance to the optical domain requires full phase and amplitude control of the optical fields. Here, we imprint a programmable microwave sequence onto a laser field and perform electron spin resonance in a semiconductor quantum dot via a two-photon Raman process. We show that this approach yields full SU(2) spin control with over 98%π-rotation fidelity. We then demonstrate its versatility by implementing a particular multi-axis control sequence, known as spin locking. Combined with electron-nuclear Hartmann–Hahn resonances which we also report in this work, this sequence will enable efficient coherent transfer of a quantum state from the electron spin to the mesoscopic nuclear ensemble.
Theoretical insight into the multiple interactions of quinazoline inhibitors with breast cancer resistance protein (BCRP/ABCG2)
Creators: name: Li, Wen-Jing
name: Chen, Xin-Hui
name: Zeng, Jia-Cheng
name: Duan, Li-Li
name: Liu, Zhao-Hua
name: Xie-Huang Sheng
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Pharmacology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences
subject: 60506 Virology

description: Communicated by Ramaswamy H. Sarma
Baryon modes in string breaking from gauge/string duality
Creators: name: Andreev, Oleg
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Theory (hep-th)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We consider the string breaking phenomenon within effective string models which purport to mimic QCD with two light flavors, with a special attention to baryon modes. We make some estimates of the string breaking distances at zero and non-zero baryon chemical potentials. Our estimates point towards the enhancement of baryon production in strong decays of heavy mesons in dense baryonic matter. We also suggest that the enhanced production of $Λ_c^+$ baryons in PbPb collisions is mainly due to larger values of chemical potential.
description: 6 pages, 3 figures; v2: typos corrected; v3: modification in title, comments and references added, journal version
Listronotus marshalli O'Brien 1981
Creators: name: Morrone, Juan J.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Listronotus
Listronotus marshalli

description: Listronotus marshalli O’Brien, 1981
 Listronotus marshalli O’Brien, 1981: 103 (type locality: USA: Florida, Gulf County, 1 mi. N White City; type material: H: CWOB and P: 63 BMNH, CWOB, ELSC, ENPC, FSCA, TAMU, and USNM).
 Distribution. Southeastern USA: Florida, Georgia, Mississippi, and Virginia (O’Brien, 1981; Anderson, 1992).
description: Published as part of Morrone, Juan J., 2011, Annotated checklist of the tribe Listroderini (Coleoptera: Curculionidae: Cyclominae) 3119, pp. 1-68 in Zootaxa 3119 (1) on page 42, DOI: 10.11646/zootaxa.3119.1.1, http://zenodo.org/record/5246257
Spectroscopy of spinons in Coulomb quantum spin liquids
Creators: name: Morampudi, Siddhardh C.
name: Wilczek, Frank
name: Laumann, Chris R.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Theory (hep-th)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We calculate the effect of the emergent photon on threshold production of spinons in $U(1)$ Coulomb spin liquids such as quantum spin ice. The emergent Coulomb interaction modifies the threshold production cross-section dramatically, changing the weak turn-on expected from the density of states to an abrupt onset reflecting the basic coupling parameters. The slow photon typical in existing lattice models and materials suppresses the intensity at finite momentum and allows profuse Cerenkov radiation beyond a critical momentum. These features are broadly consistent with recent numerical and experimental results.
description: 5 pages, 2 figures
Metal-organic framework and inorganic glass composites
Creators: name: Longley, Louis
name: Calahoo, Courtney
name: Limbach, René
name: Xia, Yang
name: Tuffnell, Joshua M.
name: Sapnik, Adam F.
name: Thorne, Michael F.
name: Keeble, Dean S.
name: Keen, David A.
name: Wondraczek, Lothar
name: Bennett, Thomas D.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Article
/639/301
/639/301/119/1002
/639/301/357/404
/128
article

description: Abstract: Metal-organic framework (MOF) glasses have become a subject of interest as a distinct category of melt quenched glass, and have potential applications in areas such as ion transport and sensing. In this paper we show how MOF glasses can be combined with inorganic glasses in order to fabricate a new family of materials composed of both MOF and inorganic glass domains. We use an array of experimental techniques to propose the bonding between inorganic and MOF domains, and show that the composites produced are more mechanically pliant than the inorganic glass itself.
Activating transcription factor-2 (ATF2) is a key determinant of resistance to endocrine treatment in an in vitro model of breast cancer
Creators: name: Giannoudis, Athina
name: Malki, Mohammed Imad
name: Rudraraju, Bharath
name: Mohhamed, Hisham
name: Menon, Suraj
name: Liloglou, Triantafillos
name: Ali, Simak
name: Carroll, Jason S.
name: Palmieri, Carlo
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Research Article
ATF2
Tamoxifen
Endocrine resistance
Breast cancer

description: Abstract: Background: Activating transcription factor-2 (ATF2), a member of the leucine zipper family of DNA binding proteins, has been implicated as a tumour suppressor in breast cancer. However, its exact role in breast cancer endocrine resistance is still unclear. We have previously shown that silencing of ATF2 leads to a loss in the growth-inhibitory effects of tamoxifen in the oestrogen receptor (ER)-positive, tamoxifen-sensitive MCF7 cell line and highlighted that this multi-faceted transcription factor is key to the effects of tamoxifen in an endocrine sensitive model. In this work, we explored further the in vitro role of ATF2 in defining the resistance to endocrine treatment. Materials and methods: We knocked down ATF2 in TAMR, LCC2 and LCC9 tamoxifen-resistant breast cancer cell lines as well as the parental tamoxifen sensitive MCF7 cell line and investigated the effects on growth, colony formation and cell migration. We also performed a microarray gene expression profiling (Illumina Human HT12_v4) to explore alterations in gene expression between MCF7 and TAMRs after ATF2 silencing and confirmed gene expression changes by quantitative RT-PCR. Results: By silencing ATF2, we observed a significant growth reduction of TAMR, LCC2 and LCC9 with no such effect observed with the parental MCF7 cells. ATF2 silencing was also associated with a significant inhibition of TAMR, LCC2 and LCC9 cell migration and colony formation. Interestingly, knockdown of ATF2 enhanced the levels of ER and ER-regulated genes, TFF1, GREB1, NCOA3 and PGR, in TAMR cells both at RNA and protein levels. Microarray gene expression identified a number of genes known to mediate tamoxifen resistance, to be differentially regulated by ATF2 in TAMR in relation to the parental MCF7 cells. Moreover, differential pathway analysis confirmed enhanced ER activity after ATF2 knockdown in TAMR cells. Conclusion: These data demonstrate that ATF2 silencing may overcome endocrine resistance and highlights further the dual role of this transcription factor that can mediate endocrine sensitivity and resistance by modulating ER expression and activity.
Additional file 1 of Mechanical ventilation enhances Acinetobacter baumannii-induced lung injury through JNK pathways
Creators: name: Tzyy-Bin Tsay
name: Wan-Hsuan Chang
name: Ching-Mei Hsu
name: Chen, Lee-Wei
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Supporting information.
Export Trade of Kerala State
Creators: name: Simon, P.J.
name: Simon, P.J.
Publisher: name: Unknown
Year: 1964
Subjects: International Relations/Trade

description: In this paper, an attempt is made to study the export behaviour of a few selescted commodities of the State. This is largely an inquiry into the economic implications of export fluctuations over a limited period of a decade. However, the dominant objective which inspired this study has been to examine the strategic character and place of 'price' in export transactions. Price is an important determinant in all transactions; but it cannot be asserted that it plays any exclusive strategy in international trade. The empirical evidence here lends support to this view.
Walling up Backdoors in Intrusion Detection Systems
Creators: name: Bachl, Maximilian
name: Hartl, Alexander
name: Fabini, Joachim
name: Zseby, Tanja
Publisher: name: arXiv
Year: 2019
Subjects: subject: Cryptography and Security (cs.CR)
subject: Machine Learning (cs.LG)
subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Interest in poisoning attacks and backdoors recently resurfaced for Deep Learning (DL) applications. Several successful defense mechanisms have been recently proposed for Convolutional Neural Networks (CNNs), for example in the context of autonomous driving. We show that visualization approaches can aid in identifying a backdoor independent of the used classifier. Surprisingly, we find that common defense mechanisms fail utterly to remove backdoors in DL for Intrusion Detection Systems (IDSs). Finally, we devise pruning-based approaches to remove backdoors for Decision Trees (DTs) and Random Forests (RFs) and demonstrate their effectiveness for two different network security datasets.
Breast cancer risk factors and their effects on survival: a Mendelian randomisation study
Creators: name: Escala-Garcia, Maria
name: Morra, Anna
name: Canisius, Sander
name: Chang-Claude, Jenny
name: Kar, Siddhartha
name: Zheng, Wei
name: Bojesen, Stig E.
name: Easton, Doug
name: Pharoah, Paul D. P.
name: Schmidt, Marjanka K.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Research Article
Breast cancer survival
Breast cancer risk factors
Lifestyle
Mendelian randomisation
GWAS Catalog

description: Abstract: Background: Observational studies have investigated the association of risk factors with breast cancer prognosis. However, the results have been conflicting and it has been challenging to establish causality due to potential residual confounding. Using a Mendelian randomisation (MR) approach, we aimed to examine the potential causal association between breast cancer-specific survival and nine established risk factors for breast cancer: alcohol consumption, body mass index, height, physical activity, mammographic density, age at menarche or menopause, smoking, and type 2 diabetes mellitus (T2DM). Methods: We conducted a two-sample MR analysis on data from the Breast Cancer Association Consortium (BCAC) and risk factor summary estimates from the GWAS Catalog. The BCAC data included 86,627 female patients of European ancestry with 7054 breast cancer-specific deaths during 15 years of follow-up. Of these, 59,378 were estrogen receptor (ER)-positive and 13,692 were ER-negative breast cancer patients. For the significant association, we used sensitivity analyses and a multivariable MR model. All risk factor associations were also examined in a model adjusted by other prognostic factors. Results: Increased genetic liability to T2DM was significantly associated with worse breast cancer-specific survival (hazard ratio [HR] = 1.10, 95% confidence interval [CI] = 1.03–1.17, P value [P] = 0.003). There were no significant associations after multiple testing correction for any of the risk factors in the ER-status subtypes. For the reported significant association with T2DM, the sensitivity analyses did not show evidence for violation of the MR assumptions nor that the association was due to increased BMI. The association remained significant when adjusting by other prognostic factors. Conclusions: This extensive MR analysis suggests that T2DM may be causally associated with worse breast cancer-specific survival and therefore that treating T2DM may improve prognosis.
Statistical and machine learning ensemble modelling to forecast sea surface temperature
Creators: name: Wolff, Stefan
name: O'Donncha, Fearghal
name: Chen, Bei
Publisher: name: arXiv
Year: 2019
Subjects: subject: Atmospheric and Oceanic Physics (physics.ao-ph)
subject: Machine Learning (cs.LG)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: In situ and remotely sensed observations have potential to facilitate data-driven predictive models for oceanography. A suite of machine learning models, including regression, decision tree and deep learning approaches were developed to estimate sea surface temperatures (SST). Training data consisted of satellite-derived SST and atmospheric data from The Weather Company. Models were evaluated in terms of accuracy and computational complexity. Predictive skill were assessed against observations and a state-of-the-art, physics-based model from the European Centre for Medium Weather Forecasting. Results demonstrated that by combining automated feature engineering with machine-learning approaches, accuracy comparable to existing state-of-the-art can be achieved. Models captured seasonal patterns in the data and qualitatively reproduce short-term variations driven by atmospheric forcing. Further, it demonstrated that machine-learning-based approaches can be used as transportable prediction tools for ocean variables -- the data-driven nature of the approach naturally integrates with automatic deployment frameworks, where model deployments are guided by data rather than user-parametrisation and expertise. The low computational cost of inference makes the approach particularly attractive for edge-based computing where predictive models could be deployed on low-power devices in the marine environment.
Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions
Creators: name: Tóth, Gergely
name: Neumann, Thomas
name: Berthet, Amandine
name: Masliah, Eliezer
name: Spencer, Brian
name: Tao, Jiahui
name: Jobling, Michael F.
name: Gardai, Shyra J.
name: Bertoncini, Carlos W.
name: Cremades, Nunilo
name: Bova, Michael
name: Ballaron, Stephen
name: Chen, Xiao-Hua
name: Mao, Wenxian
name: Nguyen, Phuong
name: Tabios, Mariano C.
name: Tambe, Mitali A.
name: Rochet, Jean-Christophe
name: Junker, Hans-Dieter
name: Schwizer, Daniel
name: Sekul, Renate
name: Ott, Inge
name: Anderson, John P.
name: Szoke, Balazs
name: Hoffman, Wherly
name: Christodoulou, John
name: Yednock, Ted
name: Agard, David A.
name: Schenk, Dale
name: McConlogue, Lisa
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Article
/631/154
/631/378
/13
/82/47
article

description: Funder: Howard Hughes Medical Institute (HHMI); doi: https://doi.org/10.13039/100000011
description: Abstract: The over-expression and aggregation of α-synuclein (αSyn) are linked to the onset and pathology of Parkinson’s disease. Native monomeric αSyn exists in an intrinsically disordered ensemble of interconverting conformations, which has made its therapeutic targeting by small molecules highly challenging. Nonetheless, here we successfully target the monomeric structural ensemble of αSyn and thereby identify novel drug-like small molecules that impact multiple pathogenic processes. Using a surface plasmon resonance high-throughput screen, in which monomeric αSyn is incubated with microchips arrayed with tethered compounds, we identified novel αSyn interacting drug-like compounds. Because these small molecules could impact a variety of αSyn forms present in the ensemble, we tested representative hits for impact on multiple αSyn malfunctions in vitro and in cells including aggregation and perturbation of vesicular dynamics. We thereby identified a compound that inhibits αSyn misfolding and is neuroprotective, multiple compounds that restore phagocytosis impaired by αSyn overexpression, and a compound blocking cellular transmission of αSyn. Our studies demonstrate that drug-like small molecules that interact with native αSyn can impact a variety of its pathological processes. Thus, targeting the intrinsically disordered ensemble of αSyn offers a unique approach to the development of small molecule research tools and therapeutics for Parkinson’s disease.
A New Non-Commutative Field Theory
Creators: name: Savvidy, Konstantin
Publisher: name: arXiv
Year: 2002
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this note we investigate a new type of non-commutative field theory based on a constant skew-symmetric three-form parameter. In 3+1 dimensions such a three-form parameter can be viewed as a short-distance regulator which nevertheless preserves spatial-rotation and at long range preserves Lorentz invariance approximately. For a scalar field theory with quartic self-interaction we obtain drastically improved ultra-violet behavior of the diagrams, due to the oscillatory dependence of the interaction vertex on the momenta. The radiative corrections to the coupling are rendered finite already at the one-loop level. The key finding of this paper is that what appears as the reemergence of UV divergences as IR singularity in $p \to 0$ limit, must be interpreted simply as the logarithmic running of the coupling. Thus at low energies the theory is virtually indistinguishable from the standard theory. Conversely at high energies the diagram converges exponentially fast, the running of the coupling stops and the theory avoids developing the Landau pole. Bare coupling defined at high energy can be kept small, and in this sense the theory is similar to asymptotically free theories.
description: 9 pages, 5 figures
Logarithmic forms and differential equations for Feynman integrals
Creators: name: Herrmann, Enrico
name: Parra-Martinez, Julio
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We describe how a dlog representation of Feynman integrals leads to simple differential equations. We derive these differential equations directly in loop momentum or embedding space making use of a localization trick and generalized unitarity. For the examples we study, the alphabet of the differential equation is related to special points in kinematic space, described by certain cut equations which encode the geometry of the Feynman integral. At one loop, we reproduce the motivic formulae described by Goncharov \cite{Goncharov:1996tate} that reappeared in the context of Feynman parameter integrals in \cite{Spradlin:2011wp,Arkani-Hamed:2017ahv}. The dlog representation allows us to generalize the differential equations to higher loops and motivates the study of certain mixed-dimension integrals.
description: 34 pages, journal version
CP violation and matter effect in long-baseline neutrino oscillation in the four-neutrino model
Creators: name: Hattori, T.
name: Hasuike, T.
name: Wakaizumi, S.
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We investigate the CP violation effect and the matter effect in the long-baseline neutrino oscillations in the four-neutrino model with mass scheme of the two pairs of two close masses separated by a gap of the order of 1 eV by using the constraints on the mixing matrix derived from the solar neutrino deficit, atmospheric neutrino anomaly, LSND experiments, and the other terrestrial neutrino oscillation experiments. We also use the results of the combined analyses by Gonzalez-Garcia, Maltoni, and Peña-Garay of the solutions to the solar and atmospheric neutrino problems with the recent SNO solar neutrino data. For the solution of close-to-active solar neutrino oscillations plus close-to-sterile atmospheric neutrino oscillations, the pure CP violation part of the oscillation probability difference between the CP-conjugate channels could attain as large as $0.10-0.25$ in the neutrino energy range of $E = 6-15$ GeV at the baseline $L = 730$ km for $ν_μ\toν_τ$ oscillation, and the matter effect is at the $8-15%$ level of the pure CP violation effect, while for the solution of near-pure-sterile solar neutrino oscillations plus near-pure-active atmospheric neutrino oscillations, the pure CP violation effect in $ΔP(ν_μ\toν_τ)$ is very small $(\sim 0.01)$ and is comparable to the matter effect. For $ν_μ\toν_e$ oscillation, the pure CP violation effect is independent of the active-sterile admixture and is at most 0.05 in $E = 1.5-3$ GeV at $L = 290$ km and the matter effect is at the $15-30%$ level.
description: 29 pages, 12 eps figures. We have shown the dependence of the CP violation effects on various parameters, discussed about the relation between the active-sterile neutrino admixture and the effects in both Tables and Figures, and added some references to the published works
Listronotus meridionalis O'Brien 1977
Creators: name: Morrone, Juan J.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Listronotus
Listronotus meridionalis

description: Listronotus meridionalis O’Brien, 1977
 Listronotus meridionalis O’Brien, 1977: 812 (type locality: Honduras: Department of Choluteca, 14 mi NW Choluteca; type material: H: CWOB and P: 8 BMNH and CWOB).
 Distribution. Costa Rica, Honduras, and southern Mexico (O’Brien, 1977, 1981; O’Brien and Wibmer, 1982).
description: Published as part of Morrone, Juan J., 2011, Annotated checklist of the tribe Listroderini (Coleoptera: Curculionidae: Cyclominae) 3119, pp. 1-68 in Zootaxa 3119 (1) on page 42, DOI: 10.11646/zootaxa.3119.1.1, http://zenodo.org/record/5246257
The fermionic universal one-loop effective action
Creators: name: Ellis, Sebastian A. R.
name: Quevillon, Jérémie
name: Vuong, Pham Ngoc Hoa
name: You, Tevong
name: Zhang, Zhengkang
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Regular Article - Theoretical Physics
Effective Field Theories
Beyond Standard Model
Gauge Symmetry

description: Abstract: Recent development of path integral matching techniques based on the covariant derivative expansion has made manifest a universal structure of one-loop effective Lagrangians. The universal terms can be computed once and for all to serve as a reference for one-loop matching calculations and to ease their automation. Here we present the fermionic universal one-loop effective action (UOLEA), resulting from integrating out heavy fermions (Dirac or Majorana) with scalar, pseudo-scalar, vector and axial-vector couplings. We also clarify the relation of the new terms computed here to terms previously computed in the literature and those that remain to complete the UOLEA. Our results can be readily used to efficiently obtain analytical expressions for effective operators arising from heavy fermion loops [13].
Theoretical Insight into the Multiple Interactions of Quinazoline Inhibitors with Breast Cancer Resistance Protein (BCRP/ABCG2)
Creators: name: Li, Wen-Jing
name: Chen, Xin-Hui
name: Zeng, Jia-Cheng
name: Duan, Li-Li
name: Liu, Zhao-Hua
name: Xie-Huang Sheng
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Usually, a molecular scaffold has one binding mode toward its target receptor. In this study, by employing chemical informatics, molecular dynamics simulations as well as binding interface analysis, we have identified three binding modes of quinazoline scaffold with breast cancer resistance protein (BCRP/ABCG2)--a well-known multidrug resistant transmembrane protein. The first class is two quinazoline molecules symmetrically bound to the central, inward-facing cavity of ABCG2 while the other two classes are one molecule bound tightly to the cavity. The compounds adopting which class of binding mode is determined by the substituent groups on the quinazoline scaffold. In all classes, quinazoline inhibitors can fully occupy the top two pockets of the cavity of ABCG2, blocking access for substrates and preventing conformational changes required for ATP hydrolysis. Meanwhile, lipophilicity and planarity of a molecule are also presupposed to be vital for a potent inhibitor. We hope the detailed structure-activity relationships (SAR) of quinazolines with ABCG2 can accelerate the development of quinazoline-containing drugs and guide the re-design of other existing scaffolds of ABCG2 inhibitors.
Parton distributions with theory uncertainties: general formalism and first phenomenological studies
Creators: name: Abdul Khalek, Rabah
name: Ball, Richard D.
name: Carrazza, Stefano
name: Forte, Stefano
name: Giani, Tommaso
name: Kassabov, Zahari
name: Pearson, Rosalyn L.
name: Nocera, Emanuele R.
name: Rojo, Juan
name: Rottoli, Luca
name: Ubiali, Maria
name: Voisey, Cameron
name: Wilson, Michael
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Regular Article - Theoretical Physics

description: Abstract: We formulate a general approach to the inclusion of theoretical uncertainties, specifically those related to the missing higher order uncertainty (MHOU), in the determination of parton distribution functions (PDFs). We demonstrate how, under quite generic assumptions, theory uncertainties can be included as an extra contribution to the covariance matrix when determining PDFs from data. We then review, clarify, and systematize the use of renormalization and factorization scale variations as a means to estimate MHOUs consistently in deep inelastic and hadronic processes. We define a set of prescriptions for constructing a theory covariance matrix using scale variations, which can be used in global fits of data from a wide range of different processes, based on choosing a set of independent scale variations suitably correlated within and across processes. We set up an algebraic framework for the choice and validation of an optimal prescription by comparing the estimate of MHOU encoded in the next-to-leading order (NLO) theory covariance matrix to the observed shifts between NLO and NNLO predictions. We perform a NLO PDF determination which includes the MHOU, assess the impact of the inclusion of MHOUs on the PDF central values and uncertainties, and validate the results by comparison to the known shift between NLO and NNLO PDFs. We finally study the impact of the inclusion of MHOUs in a global PDF determination on LHC cross-sections, and provide guidelines for their use in precision phenomenology. In addition, we also compare the results based on the theory covariance matrix formalism to those obtained by performing PDF determinations based on different scale choices.
Evaluating Expenditure Inequality Using Alternative Social Welfare Functions: A Case Study of Rural India
Creators: name: Ray, Ranjan
name: Ray, Ranjan
Publisher: name: Unknown
Year: 1985
Subjects: Community/Rural/Urban Development
Financial Economics

description: This paper examines the sensitivity of the normative estimates of inquality to: (i) changes in the planner's 'inquality averesion', (ii) a-priori changes in specification of the individual welfare functions, (iii) incorporation of price variation, (iv) incorporation of relative deprivation, and (v) the type of inquality measure employed, viz 'income inequality' as proposed by Atkinson or 'utility inequality' as proposed by Muellbauer. The empirical results, using time series of expenditure distribution for rural India [October, 1953 to July, 1974], show considerable sensitivty of the inquality magnitudes to the above factors. The paper presents theoretical evidence on the likely impact of price increases on inequality and confirms them with the empirical results. It, also, derives and applies formulae to identify items whose price increases have a relatively large impact on inequality. The paper exploits the link between inequality measurement and welfare/consumer demand theory that is opened up by the normative approach to inequality. However, the extreme sensitivity of the inequality magnitudes and the wide diesagreements between different evaluators, with different sets of prior beleifs and values, on the extent of the inequality in rural India seems to limit the operational usefulness of such measures.
Additional file 7 of Association of mental health status between self-poisoning suicide patients and their family members: a matched-pair analysis
Creators: name: Zheng, Wenjing
name: Han, Limei
name: Fan, Yanna
name: Yi, Min
name: Lu, Xiaoxia
name: Yang, Juan
name: Peng, Xiaobo
name: Yang, Ying
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Hematology

description: Additional file 7: Supplementary table 7. Multivariable analysis of significant characteristics from matched family members for predicting depression among self-poisoning suicide patients after adjusting for age and gender (n=102).
Listronotus minutus
Creators: name: Morrone, Juan J.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Listronotus
Listronotus minutus

description: Listronotus minutus (Blanchard, 1851)
 Phytonomus minutus Blanchard, 1851: 373 (type locality: Chile: Coquimbo; type material: type material: H: MNHN).
 Hyperodes minutus; Kuschel, 1950: 14.
 Listronotus minutus; O’Brien, 1979: 267.
 Distribution. Argentina, Bolivia, and Chile (Wibmer and O'Brien, 1986).
description: Published as part of Morrone, Juan J., 2011, Annotated checklist of the tribe Listroderini (Coleoptera: Curculionidae: Cyclominae) 3119, pp. 1-68 in Zootaxa 3119 (1) on page 42, DOI: 10.11646/zootaxa.3119.1.1, http://zenodo.org/record/5246257
On the Exact Evaluation of the Membrane Instanton Superpotential in M-Theory on G_2-Holonomy Manifold
Creators: name: Misra, Aalok
Publisher: name: arXiv
Year: 2002
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Following the work of Lima et al on the exact evaluation of the nonperturbative contribution to the superpotential from open-membrane instanton in Heterotic M-Theory, we evaluate systematically the contribution to the superpotential of a membrane instanton obtained by wrapping of a single M2 brane, once, on an isolated supersymmetric 3-cycle in a G_2-holonomy manifold. We then try to relate the results obtained to those sketched out in Harvey and Moore. We also do a heat-kernel asymptotics analysis to see whether one gets similar UV-divergent terms for (one or both of) the bosonic and fermionic determinants indicative of (partial) cancelation among them. The answer is in the affirmative, as expected by the supersymmetry of the starting membrane action. This work is a first step, both, in extending the work of Harvey and Moore to the evaluation of nonperturbative superpotentials for non-rigid supersymmetric 3-cycle wrappings, and in understanding the large N Chern-Simons/closed type-A topological string theory duality of Gopakumar and Vafa from M theory point of view.
description: Published version
Additional file 1 of Fasciola gigantica tegumental calcium-binding EF-hand protein 4 exerts immunomodulatory effects on goat monocytes
Creators: name: Ehsan, Muhammad
name: Rui-Si Hu
name: Hou, Jun-Ling
name: Elsheikha, Hany M.
name: Li, Xiao-Dong
name: Pan-Hong Liang
name: Zhu, Xing-Quan
Publisher: name: figshare
Year: 2021
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1: Table S1. Primer sequences used for transcriptional analysis of Fg-CaBP4 by real-time PCR. Table S2. Primer sequences used for transcriptional analysis of cytokines by real-time PCR.
A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension
Creators: name: Arnold, Nadine D.
name: Pickworth, Josephine A.
name: West, Laura E.
name: Dawson, Sarah
name: Carvalho, Joana A.
name: Casbolt, Helen
name: Braithwaite, Adam T.
name: Iremonger, James
name: Renshall, Lewis
name: Germaschewski, Volker
name: McCourt, Matthew
name: Bland-Ward, Philip
name: Kowash, Hager
name: Hameed, Abdul G.
name: Rothman, Alexander M. K.
name: Frid, Maria G.
name: Roger Thompson, A. A.
name: Evans, Holly R.
name: Southwood, Mark
name: Morrell, Nicholas W.
name: Crossman, David C.
name: Whyte, Moira K. B.
name: Stenmark, Kurt R.
name: Newman, Christopher M.
name: Kiely, David G.
name: Francis, Sheila E.
name: Lawrie, Allan
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Article
/692/699/75
/692/308/153
/64/86
/64/60
/64/110
/96/1
/9
/13
/13/95
/38
article

description: Abstract: Pulmonary arterial hypertension (PAH) is a rare but fatal disease. Current treatments increase life expectancy but have limited impact on the progressive pulmonary vascular remodelling that drives PAH. Osteoprotegerin (OPG) is increased within serum and lesions of patients with idiopathic PAH and is a mitogen and migratory stimulus for pulmonary artery smooth muscle cells (PASMCs). Here, we report that the pro-proliferative and migratory phenotype in PASMCs stimulated with OPG is mediated via the Fas receptor and that treatment with a human antibody targeting OPG can attenuate pulmonary vascular remodelling associated with PAH in multiple rodent models of early and late treatment. We also demonstrate that the therapeutic efficacy of the anti-OPG antibody approach in the presence of standard of care vasodilator therapy is mediated by a reduction in pulmonary vascular remodelling. Targeting OPG with a therapeutic antibody is a potential treatment strategy in PAH.
CP Violation in the Minimal Supersymmetric Seesaw Model
Creators: name: Ellis, John
name: Hisano, Junji
name: Lola, Smaragda
name: Raidal, Martti
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study CP violation in the lepton sector of the supersymmetric extension of the Standard Model with three generations of massive singlet neutrinos with Yukawa couplings $Y_ν$ to lepton doublets, in a minimal seesaw model for light neutrino masses and mixing. This model contains six physical CP-violating parameters, namely the phase $δ$ observable in oscillations between light neutrino species, two Majorana phases $ϕ_{1,2}$ that affect $ββ_{0 ν}$ decays, and three independent phases appearing in ${Y_ν}{Y_ν}^\dagger$, that control the rate of leptogenesis. Renormalization of the soft supersymmetry-breaking parameters induces observable CP violation at low energies, including T-odd asymmetries in polarized $μ\to eee$ and $τ\to \ell \ell \ell$ decays, as well as lepton electric dipole moments. In the leading-logarithmic approximation in which the massive singlet neutrinos are treated as degenerate, these low-energy observables are sensitive via ${Y_ν}^\dagger{Y_ν}$ to just one combination of the leptogenesis and light-neutrino phases. We present numerical results for the T-odd asymmetry in polarized $μ\to eee$ decay, which may be accessible to experiment, but the lepton electric dipole moments are very small in this approximation. To the extent that the massive singlet neutrinos are not degenerate, low-energy observables become sensitive also to two other combinations of leptogenesis and light-neutrino phases, in this minimal supersymmetric seesaw model.
description: New references added, the issue of lepton electric dipole moments in this scenario clarified, version to appear in NPB
The role of WNK in modulation of KCl cotransport activity in red cells from normal individuals and patients with sickle cell anaemia
Creators: name: Lu, David C.-Y.
name: Hannemann, Anke
name: Wadud, Rasiqh
name: Rees, David C.
name: Brewin, John N.
name: Low, Philip S.
name: Gibson, John S.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Signaling and Cell Physiology
Signaling and cell physiology
KCl cotransport
Sickle cells
Phosphorylation
WNK
SPAK/OSR1

description: Abstract: Abnormal activity of red cell KCl cotransport (KCC) is involved in pathogenesis of sickle cell anaemia (SCA). KCC-mediated solute loss causes shrinkage, concentrates HbS, and promotes HbS polymerisation. Red cell KCC also responds to various stimuli including pH, volume, urea, and oxygen tension, and regulation involves protein phosphorylation. The main aim of this study was to investigate the role of the WNK/SPAK/OSR1 pathway in sickle cells. The pan WNK inhibitor WNK463 stimulated KCC with an EC50 of 10.9 ± 1.1 nM and 7.9 ± 1.2 nM in sickle and normal red cells, respectively. SPAK/OSR1 inhibitors had little effect. The action of WNK463 was not additive with other kinase inhibitors (staurosporine and N-ethylmaleimide). Its effects were largely abrogated by pre-treatment with the phosphatase inhibitor calyculin A. WNK463 also reduced the effects of physiological KCC stimuli (pH, volume, urea) and abolished any response of KCC to changes in oxygen tension. Finally, although protein kinases have been implicated in regulation of phosphatidylserine exposure, WNK463 had no effect. Findings indicate a predominant role for WNKs in control of KCC in sickle cells but an apparent absence of downstream involvement of SPAK/OSR1. A more complete understanding of the mechanisms will inform pathogenesis whilst manipulation of WNK activity represents a potential therapeutic approach.
Discussing the first velocity dispersion profile of an ultra-diffuse galaxy in MOND
Creators: name: Bílek, Michal
name: Müller, Oliver
name: Famaey, Benoit
Publisher: name: arXiv
Year: 2019
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Using Jeans modelling, we calculate the velocity dispersion profile of the ultra-diffuse galaxy (UDG) Dragonfly 44 in MOND. For the nominal mass-to-light ratio from the literature and an isotropic profile, the agreement with the data is excellent near the center of the galaxy. However, in modified gravity, close to the cluster core, the gravitational environment should bring the galaxy back towards the Newtonian behavior. This success of the isolated MOND prediction for the central velocity dispersion could then mean that the galaxy is at large distances ($\gg5$ Mpc) from the cluster core, as hinted by the fact that close-by UDGs share similar velocities with a dispersion well below that of the cluster itself. There is however a two-sigma tension in the outer part of the UDG due to an increase of the observed dispersion profile with respect to the flat MOND prediction. This deviation could simply be a measurement error. Other possibilities could be, for a UDG far from the cluster, a higher-than-nominal baryonic mass with a tangentially anisotropic dispersion profile, or even a sign of a dark baryonic halo. If the UDG is closer to the cluster core, the deviation could be a sign that it is in the process of disruption.
description: 5 pages, 2 figures. Accepted for publication in A&A Letters