cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The role of NFATc1 in T cell-mediated immune responses during the development of lung cancer
Creators: name: Heim, Lisanne
name: Friedrich, Juliane
name: Engelhardt, Marina
name: Trufa, Denis I.
name: Geppert, Carol I.
name: Rieker, Ralf J.
name: Sirbu, Horia
name: Finotto, Susetta
Publisher: name: Proceedings on Cancer-Immuno-Oncology
Year: 2018

description: Purpose/Objectives: NFATc1 (nuclear factor of activated T cells 1) belongs to the NFAT family of transcription factors and regulates T cell activation as well as effector and cytotoxic T cell functions in many tissues. In most of the established tumors, inhibitory receptors like programmed cell death protein 1 (PD-1) contribute to the functional impairment of T cell activation by persistent tumour antigen challenge, a process that is called T cell exhaustion. Cancer immunotherapies are aimed to reawake exhausted T cells by blocking inhibitory checkpoint receptors or immunosuppressive cells. As NFATc1 is important for T cell activation we asked whether this factor could be important for the reactivation of exhausted T cells in non-small cell lung cancer (NSCLC).


Materials/Methods: We analyzed NFATc1 and its interplay with PD-1 in a human NSCLC patient cohort using qPCR, IHC and FACS. Furthermore, in a murine model of lung adenocarcinoma, we determined lung tumour growth in mice with a conditional inactivation of NFATc1 in T cells (NFATc1ΔCD4) and analyzed the influence of anti-PD-1 antibody treatment on NFATc1 protein levels in T cells of lung-tumour bearing wild-type mice.


Results and Conclusion: In this study, we report a progressive decrease of NFATc1 in lung tumor tissue and in tumor-infiltrating lymphocytes (TIL) of patients suffering from advancedstage NSCLC. NFATc1ΔCD4 mice showed increased lung tumor growth associated with impaired T-cell activation and function. Furthermore, in the absence of NFATc1, reduced IL2 influenced the development of memory CD8+ T cells. Specifically, we discovered a reduction in effector memory and CD103+ tissue-resident memory (TRM) CD8+ T cell numbers in the lung of tumor-bearing NFATc1ΔCD4, underlining an impaired cytotoxic T-cell response and a reduced TRM tissue-homing capacity. Targeting PD-1 resulted in NFATc1 induction in CD4+
and CD8+ T cells in tumor-bearing mice and was associated with increased antitumor cytotoxic functions. Thus this study reveals a role of NFATc1 in the activation and cytotoxic functions of T cells, in the development of memory CD8+ T-cell subsets, and in the regulation of T-cell exhaustion. These data underline the indispensability of NFATc1 for successful antitumor immune responses in patients with NSCLC.
description: Proceedings on Cancer-Immuno-Oncology, Vol 1 No 1 (2018)
Pentacrinitinae Gray 1842
Creators: name: Roux, Nadia Améziane Marc Eléaume Michel
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Crinoidea
Isocrinida
Pentacrinitidae

description: Subfamily Pentacrinitinae Gray, 1842
Well-developed stalk; numerous long arms and pinnules, arm division endotomous beyond IIBrax, usually arm synostoses absent or restricted to IIBr6 + 7. Included genera: Pentacrinites and Seirocrinus. Triassic–Late Jurassic.
description: Published as part of Roux, Nadia Améziane Marc Eléaume Michel, 2024, Classification of Isocrinida (Echinodermata: Crinoidea) with the description of a new extant genus and species from the western Pacific, pp. 994-1012 in Zoological Journal of the Linnean Society (Zool. J. Linn. Soc.) (Zool. J. Linn. Soc.) 200 (4) on page 1009, DOI: 10.1093/zoolinnean/zlad101, http://zenodo.org/record/11240631
Opportunity Denied
Creators: name: Anand, Davinder K.
Publisher: name: Digital Repository at the University of Maryland
Year: 2024
Subjects: black engineers
opportunity
education
technology
history

description: After a considerable amount of discussion, I decided to touch on a topic mostly ignored in the engineering curriculum. That is the participation of Black people in the areas of engineering and technology. The issue of Black Lives Matter and the widespread protests in 2020 have forced us to examine the long-standing opportunities in technology denied to this community. In this paper I review a brief history of how we got to this point and the challenges inherent in the educational system. At the end I discuss some deeply ingrained and difficult-to-change issues and present some final thoughts on this very complex situation. - Davinder K. Anand.
Black fatherhood in contemporary African American novels
Creators: name: Khayat, Daniah
Publisher: name: University of Limerick
Year: 2024
Subjects: classificationCode: 47
subject: Language, communication and culture

description: This thesis examines popular genre conventions to illuminate Black men’s position as fathers in relation to a contemporary and historical situation with racial laws and cultural stereotypes that created an exceptional situation for Black men’s paternity, whether in the past or the present. It also identifies how contemporary Black authors, through these genres, challenge the racial stereotypes about Black fatherhood found in policies, public discourses, and the political arenas. It also examines how this contemporary representation constructs a new cultural identity for Black fatherhood. I argue that contemporary African American novels challenge Black fathers’ marginalisation in the American cultural imagination by using popular genres to represent them in diverse manners, like being involved and nurturing, and explaining the reasons behind their inability, shortcomings, and absence in relation to contemporary and historical racial contexts. This analysis is established by closely reading rhetorical strategies related to four popular genres: crime fiction, satire, Gothic, and domestic fiction, in four African American contemporary novels: Before I Forget (2009) by Leonard Pitts Jr., The Sellout (2015) by Paul Beatty, Sing, Unburied, Sing (2017) by Jesmyn Ward and An American Marriage (2018) by Tayari Jones. This analysis shows that genre does not have a fixed formula but an adaptable art that is constantly changing. Black novelists’ creative intervention in popular genres refreshes these genres and contributes to their longevity. This analysis also complicates Obama’s neoliberal dichotomy that brands Black fathers as either responsible and irresponsible, masculine and childish, by illustrating how the Black father characters engage with their children and express their fatherhood in distinctive and creative ways. It undermines the idea of “good” versus “bad” fatherhood to rescue the Black race from loss, as seen in Obama’s rhetoric. Black fathers’ figures are far more complex because they relate to historical and cultural contexts and dynamics.
title: Parataxe und Hypotaxe in einem mittelbairischen Dialekt am Beispiel Gainfarn
Creators: name: Mayer, Sabrina
Year: 2010

description: Die vorliegende Diplomarbeit stellt das Ergebnis dialektologischer Feldforschungen in Gainfarn (Niederösterreich) dar. Sie ist als synchrone Dokumentation syntaktischer Strukturen in diesem Gebiet, das Teil des mittelbairischen Dialektraums ist, zu verstehen. Die Funktionen ausgewählter Konjunktionen (dass, weil, wann, und etc.) und somit die Verwendung parataktischer sowie hypotaktischer Strukturen werden eingehend erörtert. Aufgezeigt wird, dass zahlreiche Konjunktionen auf unterschiedlichen syntaktischen, semantischen und pragmatischen Ebenen agieren. Besondere Beachtung wird so den vielfältigen und unterschiedlichen Funktionen einzelner Konjunktionen zuteil.
Additional file 2 of Comparison of step-count outcomes across seven different activity trackers: a free-living experiment with young and older adults
Creators: name: Nakagata, Takashi
name: Yamada, Yosuke
name: Taniguchi, Masashi
name: Nanri, Hinako
name: Kimura, Misaka
name: Miyachi, Motohiko
name: Ono, Rei
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 2
CAR NK cells for cancer retargeting
Creators: name: Esser, Ruth
name: Koehl, Ulrike
name: Glienke, Wolfgang
name: Morgan, Michael
name: Kaiser, Andrew
name: Abken, Hinrich
name: Heuser, Michael
name: Aleksandrova, Krasimira
name: Leise, Jana
name: Oberschmidt, Olaf
name: Priesner, Christoph
name: Arseniev, Lubomir
name: Schambach, Axel
name: Kloess, Stephan
Publisher: name: Proceedings on Cancer-Immuno-Oncology
Year: 2018

description: Adaptive immunotherapy using redirected chimeric antigen receptor (CAR) T cells against leukemia has led to promising results with improved patient survival. The continuously increasing interest in those advanced gene therapy medicinal products leads to a manufacturing challenge regarding automation, process robustness, and cell storage. In this respect our results from a study for relapsed Melanoma regarding manufacturing of CAR T cells in a closed and automated system gives rise to improve harmonized manufacturing protocols for engineered T cells in future gene therapy studies. In contrast to T cells, natural killer (NK) cells are known to mediate anti-cancer effects without the risk of inducing graft-versus-host disease, which makes them a promising source for third-party-donor immunotherapy. However, tumor cells can escape NK cell immunosurveillance by tumor immune escape mechanisms (TIEMs). In order to overcome TIEMs and to make NK cell-based therapies more specific, we engineered primary human NK cells to express a CAR designed to recognize CD19 or CD123, which are highly expressed on the surface of primary acute lymphoblastic or myeloid leukemia, respectively. NK cells were transduced with state-of-the-art alpharetroviral self-inactivating (SIN) vectors encoding EGFP alone as control or a second or third generation CAR engineered with an anti-CD19 or anti-CD123 single chain variable fragment (scFv) and containing the CD28 transmembrane domain, the 4-1BB costimulatory domain, the CD3ζ signaling domain and an internal ribosomal entry site (IRES) element for EGFP expression. CAR-modified NK cells showed a strongly improved cytotoxicity against leukemic cells compared to activated NK cells with a nearly complete elimination of leukemic cells after 48 h. Moreover, our side-effect studies demonstrated minimal or no cytotoxicity of CAR NK cells against PBMNCs and lung epithelia cells, respectively.


Since autologous T cells cannot consistently be expanded ex vivo for all patients, third-party allogeneic CAR NK cells as an “off the shelf product” may serve as an alternative strategy. Since NK cells have a significantly shorter lifespan than T cells, off-tumor toxicity might be reduced. However, for durable anti-tumor effects immature CAR NK cells or repeated cell infusions of mature CAR NK cells might be necessary.
description: Proceedings on Cancer-Immuno-Oncology, Vol 1 No 1 (2018)
Immune biological rationale for the design of radioimmunotherapies
Creators: name: Gaipl, Udo S.
Publisher: name: Proceedings on Cancer-Immuno-Oncology
Year: 2018

description: Radiotherapy primarily aims to induce tumor cell death. However, it has become evident that it also impacts on the tumor cell phenotype and its micro-environment thereby exerting both immune suppression and activation. Therefore, a deeper understanding of how radiotherapy modulates the immune system is mandatory for the design of radioimmunotherapies. The talk will focus on immune modulations by radiotherapy, taken also into account the impact of radiation dose and timing of combination with immunotherapies on it. Immune biological challenges for combining radiotherapy with additional immune modulators are discussed. Based on the inflammatory status of a tumor, the dynamics and the interconnections of the immune system and the tumor are outlined. Finally, genetic and immune biomarkers for radiation responses are specified for improvement of radioimmunotherapies. It can be concluded that local and systemic antitumor immune responses can be induced by radiotherapy, but predominantly only in combination with additional immune modulations.
description: Proceedings on Cancer-Immuno-Oncology, Vol 1 No 1 (2018)
In-Hospital Mortality and Resource Utilization of Patients with COVID-19 by Ethnicity
Creators: name: Ayala, Alexander Evans
name: Alhalel, Jonathan
name: Santoiemma, Phillip Pasquale
name: Venkatesh, Omkar
name: Young, Ashley
name: Walsh, Emily E.
name: Chokshi, Anuj Kalpesh
name: Schusler, Ryan David
name: Zhang, Yue
name: John, Jordan
name: Schumacher, Frank
name: Sheehan, Karen M.
name: Achenbach, Chad J.
Publisher: name: Prism. Galter Health Sciences Library. Northwestern University
Year: 2021
Subjects: subject: COVID-19
subject: Ethnicity
subject: Chicago, Ill.
subject: Critical Care Outcomes
subject: Hispanic or Latino
subject: Latinx patients
subject: Healthcare Disparities

description: Background

To date, investigations have focused on age-, race- and sex-related differences in COVID-19-associated outcomes. However, differences in COVID-19-associated outcomes related to ethnicity remain underrepresented in the literature.

 

Methods

In this clinical cohort study, we included adults hospitalized with COVID-19 and confirmed SARS-CoV-2 infection across the Northwestern Medicine health system in the Chicago area between March and June 2020. Individuals were initially identified utilizing NM Electronic Data Warehouse with details of presentation, symptoms, key therapies, and hospital outcomes verified by clinician case review. We assessed outcomes of oxygen use, hospital length of stay (LOS), ICU care and LOS, intubation and duration, and COVID-related death comparing across ethnic groups using multivariable Cox models.     

 

Results

Of the 1,947 adults hospitalized with COVID-19 included in our analyses, 37.49% identified as Latinx, and 24.16% preferred Spanish as their primary language. Compared with non-Latinx patients, Latinx patients were younger, more likely to be men and less likely to have asthma, COPD, T2DM, and CVD. Yet they required similar days of supplemental oxygen support and required a longer ICU LOS. In unadjusted time-to-event analyses, being Latinx was associated with a lower risk of COVID-related, in-hospital mortality (HR .512 [95% CI .370-709]). After adjustment for age, sex, insurance, comorbidities, and biomarkers, ethnicity was not independently associated with ICU admission, COVID-19-related mortality, or need for mechanical ventilation.

 

Conclusions

This study demonstrated that ethnicity is not an independent prognostic factor in patients hospitalized with COVID-19 disease after controlling for age, sex, insurance, comorbidities, and biomarkers.
description: Funding source: Gilead Sciences Inc. [Prot#GS-US-540-5807]
Eocomatulinae Simms 1988
Creators: name: Roux, Nadia Améziane Marc Eléaume Michel
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Crinoidea
Isocrinida
Pentacrinitidae

description: Subfamily Eocomatulinae Simms, 1988 sensu Hess, 2011b
Rudimentary stalk, ligamentary articulations common throughout arm. Monogeneric: Eocomatula. Late Triassic–Early Jurassic.
description: Published as part of Roux, Nadia Améziane Marc Eléaume Michel, 2024, Classification of Isocrinida (Echinodermata: Crinoidea) with the description of a new extant genus and species from the western Pacific, pp. 994-1012 in Zoological Journal of the Linnean Society (Zool. J. Linn. Soc.) (Zool. J. Linn. Soc.) 200 (4) on page 1009, DOI: 10.1093/zoolinnean/zlad101, http://zenodo.org/record/11240631
Role of resident memory T cells in cancer immunotherapy
Creators: name: Tartour, Eric
Publisher: name: Proceedings on Cancer-Immuno-Oncology
Year: 2018

description: Recent studies show that tissue resident memory T cells (TRM) are emerging as essential actors involved in tissue immunosurveillance. This role partly relies on their specific expression of adhesion molecules (CD103 or CD49a integrins, chemokine receptors) facilitating their retention into tissues and consequently into tumor. Their well-positioned location in close contact with tumor cells, their enrichment in tumor specific T cells, as well as their higher cytotoxic capacities explain that their tumor infiltration is correlated with good clinical outcome in many cancers. We and other groups have shown that the efficacy of cancer vaccines depends on their ability to elicit TRM. In adoptive cell therapy, the transfer of cells with the ability to establish TRM at the tumor site correlates with the potency of this therapy. Interestingly, TRM express immune checkpoint molecules and preliminary data showed that they could expand early during anti-PD-1 treatment, and thus be considered as a surrogate marker of response to immunotherapy. Overall, TRM cells appear to represent important components in cancer immunology both as a potential biomarker of response to immunotherapy and as critical effector cells required for the success of various immunotherapy approaches.
description: Proceedings on Cancer-Immuno-Oncology, Vol 1 No 1 (2018)
Additional file 1 of Blood lipid profiles as a prognostic biomarker in idiopathic pulmonary fibrosis
Creators: name: Oh, Ju Hyun
name: Chae, Ganghee
name: Song, Jin Woo
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Hematology

description: Supplementary Material 1
Perspectives of human gamma/delta T-cells in cancer immunotherapy
Creators: name: Kabelitz, Dieter
Publisher: name: Proceedings on Cancer-Immuno-Oncology
Year: 2018

description: γδ T-cells comprise a numerically small subset of CD3-positive T-cells in peripheral blood but occur at increased frequencies in mucosal tissues. The major subset of human blood γδ T-cells expresses a Vγ9Vδ2-encoded T-cell receptor (TCR) which specifically recognizes pyrophosphate intermediates of the cholesterol synthesis (mevalonate) pathway from microbes and tumor cells. Many tumors have a dysregulated mevalonate pathway and produce increased levels of intermediates (e.g., isopentenyl pyrophosphate, IPP) which are then specifically sensed by γδ T-cells. Recognition of such pyrophosphates is not dependent on HLA presentation but requires the butyrophilin member BTN3A1 (also termed CD277). Due to their HLA-independent killing of many different tumor cells, γδ T-cells have recently raised great interest as potential effector cells for cell-based immunotherapy. In some studies, however, γδ T-cells have also been reported to actually exert pro-tumorigenic activities. I will discuss anti- and pro-tumorigenic activities of γδ T-cells with a focus on strategies how to improve the efficacy of tumor cell killing by human γδ T-cells. This may include the development of bispecific antibodies targeting γδ T-cells to tumor-associated cell surface antigens and the design of other strategies to specifically enhance the cytotoxic capacity of γδ T-cells. On the other hand, it will be important to counteract known inhibitory mechanisms of the tumor microenvironment such as e.g. prostaglandin E2 and certain galectins. Furthermore, the sensitivity of some tumor cells towards γδ T-cell mediated cytotoxicity can be improved by epigenetic modifiers such as histone deacetylase inhibitors. The overall goal is to improve cytotoxic effector activity of γδ T-cells (and therefore to pave the way to clinical application) by enhancing cytotoxic mechanisms while simultaneously inhibiting suppressive mechanisms.
description: Proceedings on Cancer-Immuno-Oncology, Vol 1 No 1 (2018)
Die  Spitze des Piz Muttler : durch Fernrohr gezeichnet vom Weg ins Scarl Thal ob Schuls
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1869

description: J Müller
description: Gehört zu den Ansichten und Panoramen, die früher als Doubletten bezeichnet wurden. Es handelt sich jedoch um feiner oder weiter ausgearbeitete Zeichnungen, Vorstufen zu Reinzeichnungen oder Sammlungsstücken, die bisher weder katalogisiert noch signiert wurden
description: Vgl. "Die Spitze des Piz Muttler", Signatur: [Müller-Wegmann] XXV 45 und "Die Spitze des Piz Muttler", Signatur: [Müller-Wegmann] P 228
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Sonnenfleckenzeichnung Nr. 2021.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 03.01.1896, erstellt von Alfred Wolfer
Creators: name: Eidgenössische Sternwarte in Zürich (ETH Zürich bzw. vor 1911 Polytechnikum)
Publisher: name: [s.n.]
Year: 1896

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Kern-Merz-Refraktor.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zugeordnete numerische Werte wurden in einer separat geführten, chronologischen Tabelle erfasst. Unter Umständen sind tabellarisch notierte Werte, die für Protuberanzen mit rot geschrieben wurden, direkt auf der Fleckenzeichnung vermerkt
description: ETH-Bibliothek
On the development of personalized cancer vaccines
Creators: name: Rammensee, Hans-Georg
Publisher: name: Proceedings on Cancer-Immuno-Oncology
Year: 2018

description: Cancer immunotherapy has experienced a breakthrough by the introduction of checkpoint inhibition with antibodies. Response appears to be correlated with mutation load; the majority of cancer patients are nonresponders, possibly due to absence of immunogenic neoepitopes. We analyze the entire detectable landscape of HLA ligands on tumor samples, consisting of 1000 through 5000 peptides per sample, and find dozens to hundreds of peptides in germline sequence with apparently tumor specific expression, based on the absence of these peptides on adjacent autologous benign tissue and absence on a large number of normal tissue samples from all organs and tissue types available for analysis. We have evidence that non-mutated HLA ligands with tumor specific expression should be efficient as targets for personalized antigen specific immunotherapy, in particular if used with an efficient adjuvant.
description: Proceedings on Cancer-Immuno-Oncology, Vol 1 No 1 (2018)
Platelets regulate innate immunity in autoinflammatory diseases and cancer
Creators: name: Franklin, Bernardo Simoes
Publisher: name: Proceedings on Cancer-Immuno-Oncology
Year: 2018

description: The interleukin (IL)-1 family of pro-inflammatory cytokines are the most potent pyrogens in the body, and their excessive production can cause several auto- inflammatory syndromes, or contribute to a range of inflammatory and metabolic disorders. Furthermore, IL-1β is an important driver of tumor development and metastasis. The recent success of the first and largest randomized trial of the therapeutic monoclonal IL-1β antibody Canakinumab in human beings provided evidence that IL-1 is associated with increased incidence of fatal lung cancer. The expression of the key members of the IL-1 family, such as IL-1β a nd I L-18, is regulated at both the transcriptional and post-transcriptional levels. IL-1β a nd I L-18 are produced as inactive precursors, which require activation of caspase-1 by the inflammasomes for their maturation and release by from cells, occasionally at the cost of caspase-1-mediated cell death. We have recently discovered that inflammasomes are released into the extracellular space where they remain active after the demise of activated cells, and that extracellular inflammasomes can amplify inflammation by sustaining extracellular production of IL-1β. However, the sources of extracellular pro-IL-1β are not known. Recent advances in platelet proteomics have revealed that these non-nucleated cells are able to produce their own cytokines, including soluble IL-1β and membrane-bound IL-1α, and are able to significantly magnify IL-1 production by immune cells. As platelets outnumber leukocytes by several folds, they could potentially be the major source of extracellular inflammasomes in the body, or be a major producer of IL-1 precursors that are
cleaved by extracellular inflammasomes released from dying immune cells. In this study, we investigated the mechanism(s) by which platelets produce IL-1, and the specific contribution of platelet- derived IL-1 to sterile inflammation, or host resistance to infection. We believe that a deeper understanding of platelet-IL-1 and their interaction with immune cells during sterile inflammation, or infection might help to uncover new targets for immune therapies.
description: Proceedings on Cancer-Immuno-Oncology, Vol 1 No 1 (2018)
Arctopsyche ladogensis
Creators: name: Kong, Sun-Jin Park and Dongsoo
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Hydropsychidae
Arctopsyche
Arctopsyche ladogensis

description: 1. Arctopsyche ladogensis (Kolenati, 1859) ǡẃ날AE래
 Aphelocheira ladogensis Kolenati, 1859, Gen Spec Trich 2, 145, 147, 165, 183, 201, pl 1 f 4.
 Arctopsyche ladogensis (Kolenati, 1859): Yoon and Kim 1988, 460 - 461, f 11, S (GG, GW), L.
 Remarks. This species was recorded solely based on larval specimens by Yoon and Kim (1988). Their descriptions and illustrations mostly agree with those provided by Lepneva (1964) and Ruiter et al. (2013), but the adult has not been reported from Korea.
description: Published as part of Kong, Sun-Jin Park and Dongsoo, 2020, A checklist of Trichoptera (Insecta) of the Korean Peninsula, pp. 288-323 in Journal of Species Research 9 (3) on page 290, DOI: 10.12651/JSR.2020.9.3.288, http://zenodo.org/record/13141222
Isocrinidae Gislen 1924
Creators: name: Roux, Nadia Améziane Marc Eléaume Michel
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Crinoidea
Isocrinida
Isocrinidae

description: Family Isocrinidae Gislén, 1924
Stalk symplexies of isocrinine type, proximal cirri oriented upwards; number of brachials>5, often>10, in secundibrachitaxes substantially increasing distally.
description: Published as part of Roux, Nadia Améziane Marc Eléaume Michel, 2024, Classification of Isocrinida (Echinodermata: Crinoidea) with the description of a new extant genus and species from the western Pacific, pp. 994-1012 in Zoological Journal of the Linnean Society (Zool. J. Linn. Soc.) (Zool. J. Linn. Soc.) 200 (4) on page 1009, DOI: 10.1093/zoolinnean/zlad101, http://zenodo.org/record/11240631
Additional file 2 of Blood lipid profiles as a prognostic biomarker in idiopathic pulmonary fibrosis
Creators: name: Oh, Ju Hyun
name: Chae, Ganghee
name: Song, Jin Woo
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Hematology

description: Supplementary Material 2
A pan-cancer landscape of interactions between tumors and infiltrating immune cells
Creators: name: Tamborero, David
Publisher: name: Proceedings on Cancer-Immuno-Oncology
Year: 2018

description: Throughout their development, tumors are challenged by the immune system and acquire features to evade its surveillance. A systematic view of these traits is still lacking. We recently performed a computational-based study in which we identified genomic and transcriptomic traits associated to the immune-phenotype of 9,403 tumors of 29 solid cancers. In highly cytotoxic immune-phenotypes we found tumors with low clonal heterogeneity enriched by alterations of genes involved in epigenetic regulation, ubiquitin mediated proteolysis, antigen-presentation and cell-cell communication, which may drive resistance. Tumors with immune-phenotypes with mid cytotoxicity present an over-activation of processes involved in invasion and remodeling of neighboring tissues that may foster the recruitment of immune-suppressive cells. Tumors with poor cytotoxic immune-phenotype tend to be of more advanced stages and present frequent alterations in cell cycle, hedgehog, beta-catenin and TGF-beta pathways, which may drive the immune depletion. These results may be exploited to better understand the outcome of immunetherapies and develop novel combinatorial targeting strategies.
description: Proceedings on Cancer-Immuno-Oncology, Vol 1 No 1 (2018)
Der  Pz. Muttler und Arina gezeichnet am Weg ins Scarl Thal von der Höhe ob Schuls
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1869

description: J Müller
description: Gehört zu den Ansichten und Panoramen, die früher als Doubletten bezeichnet wurden. Es handelt sich jedoch um feiner oder weiter ausgearbeitete Zeichnungen, Vorstufen zu Reinzeichnungen oder Sammlungsstücken, die bisher weder katalogisiert noch signiert wurden
description: Vgl. "Der Piz Muttler und Arina vom Weg ob Schuls ins Scarl-Thal", Signatur: [Müller-Wegmann] XXV 44 und "Der Piz Muttler und Arina gez von Weg ob Schuls im Scarl Thal", Signatur: [Müller-Wegmann] P 217
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Arctopsyche palpata Martynov 1934
Creators: name: Kong, Sun-Jin Park and Dongsoo
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Hydropsychidae
Arctopsyche
Arctopsyche palpata

description: 2. Arctopsyche palpata Martynov, 1934 ÷šǡẃ날AE래
 Arctopsyche palpata Martynov, 1934, Tabl analyt Faune URSS 13, 251 - 252, 339, f 182a - c; Botosaneanu 1970, 296, N (HGB, PB), M, F; Kobayashi 1989, 2 - 3, S (GN), M; Malicky 1993, 14, N (PB), M; Lee and Kim 1993, 265, N (RG), L; Choe and Woo 1998, 74, S (JN), M; Hwang 2006, 54 - 55, f 121 - 125, S (GN, GW, JN), M, F; Oláh et al. 2018, 109, N (PB), M.
description: Published as part of Kong, Sun-Jin Park and Dongsoo, 2020, A checklist of Trichoptera (Insecta) of the Korean Peninsula, pp. 288-323 in Journal of Species Research 9 (3) on page 290, DOI: 10.12651/JSR.2020.9.3.288, http://zenodo.org/record/13141222
Isocrininae Gislen 1924
Creators: name: Roux, Nadia Améziane Marc Eléaume Michel
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Crinoidea
Isocrinida
Isocrinidae

description: Subfamily Isocrininae Gislén, 1924
Two primibrachials, usually embayed synarthry at IBr1 + 2, deep brachial symmorphies in Jurassic genera. Included genera: see Figure 12. Middle Triassic–Early Oligocene.
description: Published as part of Roux, Nadia Améziane Marc Eléaume Michel, 2024, Classification of Isocrinida (Echinodermata: Crinoidea) with the description of a new extant genus and species from the western Pacific, pp. 994-1012 in Zoological Journal of the Linnean Society (Zool. J. Linn. Soc.) (Zool. J. Linn. Soc.) 200 (4) on page 1009, DOI: 10.1093/zoolinnean/zlad101, http://zenodo.org/record/11240631
D2.1 Profiling Methodological Foundations
Creators: name: Frankfurt University
name: Hellenic Red Cross
name: Child, The Smile Of The
name: NTUA
Publisher: name: Zenodo
Year: 2018
Subjects: missing child profile, behavioural data, activity data, profiling

description: This deliverable is related to the first release of the methodology for timely and effectively profiling missing children, based both on behavioural and activity data.
Die  Spitze des Piz Muttler : durch Fernrohr gezeichnet vom Weg ins Scarl Thal ob Schuls (unter Engadin)
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1869

description: IM.
description: Gehört zu den Ansichten und Panoramen, die früher als Doubletten bezeichnet wurden. Es handelt sich jedoch um feiner oder weiter ausgearbeitete Zeichnungen, Vorstufen zu Reinzeichnungen oder Sammlungsstücken, die bisher weder katalogisiert noch signiert wurden
description: Vgl. "Die Spitze des Piz Muttler", Signatur: [Müller-Wegmann] XXV 45 und "Die Spitze des Piz Muttler", Signatur: [Müller-Wegmann] P 225
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
title: Die Geschäftsordnung des Nationalrates im Vergleich mit der Geschäftsordnung des Deutschen Bundestages unter besonderer Berücksichtigung der Minderheitenrechte und der Rechte des einzelnen Abgeordneten
Creators: name: Möhrle, Felix Stephan
Year: 2010

description: Die vorliegende Arbeit untersucht anhand eines funktionalen Rechtsvergleichs die Unterschiede und Gemeinsamkeiten der Geschäftsordnungen des Österreichischen Nationalrates und des Deutschen Bundestages. Die Geschäftsordnungen, zentrale Instrumente im verfassungsrechtlich und politisch vorgegebenen Rahmen der parlamentarischen Demokratie, werden im Kontext ihrer praktischen Bedeutung für den Parlamentsalltag und für das verfassungsrechtliche Gefüge beleuchtet. Das Hauptaugenmerk der Untersuchung liegt dabei auf den parlamentarischen Minderheitenrechten sowie auf den Rechten des einzelnen Abgeordneten. Die Arbeit legt zunächst die Entwicklung der parlamentarischen Rechtsgrundlagen in Österreich und Deutschland dar, die trotz desselben historischen Ursprungs maßgebliche Unterschiede im modernen Parlamentarismus der beiden Länder hervorgebracht haben. Nach der Einordnung in das jeweilige Rechtsquellensystem werden ferner die Rechtsfolgen verglichen, die auf den unterschiedlichen Charakter der Geschäftsordnungen zurückgehen. Vor dem Hintergrund der europäischen Integration bildet die Arbeit überdies ab, welche Mitwirkungsrechte der Nationalrat und der Deutsche Bundestag am Rechtsetzungsverfahren der Europäischen Union besitzen. Konkret werden die Auswirkungen des Vertrags von Lissabon auf die Praxis und den Wesensgehalt des österreichischen und deutschen Parlamentarismus‘ analysiert. Die Kontraste in der Organisation der Parlamente und der Ausgestaltung des Abgeordnetenstatus‘ bilden einen Kern der Arbeit. Beim Vergleich der Rechte und Pflichten eines Nationalratsabgeordneten mit denen eines Bundestagsabgeordneten wird die verfassungsrechtliche Stellung des Mandatars einbezogen, aber auch Rechtsfragen in Hinblick auf die Immunität der Abgeordneten. Von besonderer Relevanz ist, wie unterschiedlich die jeweiligen Minderheitenrechte gemäß Verfassung und Geschäftsordnung ausgeprägt sind. Die Arbeit integriert hier Vorschläge zu möglichen Reformen der Geschäftsordnungen. Schließlich werden auch die jeweiligen Rechtsschutzinstrumente dargestellt, die einen parlamentsrechtlichen Bezug aufweisen. Der Verfasser kommt zu dem Schluss, dass der österreichische und deutsche Parlamentarismus sich die Geschäftsordnung der jeweils anderen Volksvertretung zumindest teilweise zum Vorbild nehmen können. So empfiehlt er beispielsweise, das parlamentarische Untersuchungsrecht des Nationalrates als Minderheitenrecht auszugestalten. Dem Bundestag schlägt er etwa vor, Elemente aus dem lebendigen und direkten parlamentarischen Fragerecht des Nationalrates zu übernehmen.
Additional file 1 of A high-volume study on the impact of diabetes mellitus on clinical outcomes after surgical and percutaneous cardiac interventions
Creators: name: Slingerland, S. R.
name: Schulz, D. N.
name: van Steenbergen, G. J.
name: Soliman-Hamad, M. A.
name: Kisters, J. M. H.
name: Timmermans, M.
name: Teeuwen, K.
name: Dekker, L.
name: van Veghel, D.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Virology

description: Supplementary Material 1
Balanocrinidae Roux 1981
Creators: name: Roux, Nadia Améziane Marc Eléaume Michel
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Crinoidea
Isocrinida
Balanocrinidae

description: Family Balanocrinidae Roux, 1981
Two primibrachials; trend to decrease of proximal brachitaxes length;trend to development of marginal crenulae or multiradiate crenularium in stalk symplexies except in Diplocrininae. Uncertain subfamily attribution: Cenocrinus (Recent).
description: Published as part of Roux, Nadia Améziane Marc Eléaume Michel, 2024, Classification of Isocrinida (Echinodermata: Crinoidea) with the description of a new extant genus and species from the western Pacific, pp. 994-1012 in Zoological Journal of the Linnean Society (Zool. J. Linn. Soc.) (Zool. J. Linn. Soc.) 200 (4) on page 1010, DOI: 10.1093/zoolinnean/zlad101, http://zenodo.org/record/11240631
Balanocrininae sensu Roux 1981
Creators: name: Roux, Nadia Améziane Marc Eléaume Michel
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Crinoidea
Isocrinida
Isocrinidae

description: Subfamily Balanocrininae Roux, 1981
Usually stalk symplexies of balanocrinine type, cirri oriented upwards or moderately downwards, usually embayed synarthry at IBr1 + 2 and IIBr1 + 2, often deep symmorphies in arms. Included genera: see Figure 12. Middle Triassic–Recent.
description: Published as part of Roux, Nadia Améziane Marc Eléaume Michel, 2024, Classification of Isocrinida (Echinodermata: Crinoidea) with the description of a new extant genus and species from the western Pacific, pp. 994-1012 in Zoological Journal of the Linnean Society (Zool. J. Linn. Soc.) (Zool. J. Linn. Soc.) 200 (4) on page 1010, DOI: 10.1093/zoolinnean/zlad101, http://zenodo.org/record/11240631
Cheumatopsyche albofasciata
Creators: name: Kong, Sun-Jin Park and Dongsoo
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Hydropsychidae
Cheumatopsyche
Cheumatopsyche albofasciata

description: 5. Cheumatopsyche albofasciata (McLachlan, 1872)
 ÊƦ꼬마ẃ날AE래
 Hydropsyche albofasciata McLachlan, 1872a, Ann Soc Ent Belg 15, 68, pl 2 f 6 - 6b.
 Cheumatopsyche albofasciata (McLachlan, 1872): Mey 1989, 302, N (PB), M; Kumanski 1992, 66 - 67, f 48 - 51, N (PB, PY), M, F; Hwang and Yoon 1996, 9, f 4, 8g - h, S (CN, GG), M, F; Choe and Woo 1998, 74, S (JN), M; Hwang 2006, 63 - 64, f 146 - 150, S (CB, GG, GW), M, F.
description: Published as part of Kong, Sun-Jin Park and Dongsoo, 2020, A checklist of Trichoptera (Insecta) of the Korean Peninsula, pp. 288-323 in Journal of Species Research 9 (3) on page 290, DOI: 10.12651/JSR.2020.9.3.288, http://zenodo.org/record/13141222
AKSIYADORLIK JAMIYATLARIDA BIZNES-JARAYONLARNI SAMARALI BOSHQARISHNING NAZARIY ASOSLARI VA O'ZIGA XOS XUSUSIYATLARI
Creators: name: Sarimsakov, Mashxurbek
name: Sidikov, Akmaljon
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqola O‘zbekiston aktsiyadorlik jamiyatlarida biznes-jarayonlarni samarali boshqarishning nazariy asoslari va amaliyotdagi o‘ziga xos xususiyatlarini tahlil qiladi. Maqola, korporativ boshqaruv tizimida biznes-jarayonlarni optimallashtirish va samaradorlikni oshirish yo‘llarini ko‘rib chiqadi. Shuningdek, biznes-jarayonlarni rivojlantirishda duch keladigan asosiy muammolar va ularni hal etish bo‘yicha zamonaviy yechimlar taqdim etiladi.
Contrast Optimized Stimulus Generator (Cosgen)
Creators: name: Aymanns, Florian
name: Ioanas, Horea-Ioan
name: Rudin, Markus
Publisher: name: Zenodo
Year: 2017
Subjects: fMRI
genetic algorithm
optimization
study design
stimulation protocol
signal detection
biomedical imaging
impulse response functio
signal estimation
contrast optimization
first level statistics
autoregression
brain imaging
engineering
free and open source

description: As fMRI measurements are complex, expensive, and often target low-amplitude effects, the

statistical optimization of stimulus sequences for specific experimental targets plays an integral

role in the experiment design process. We provide an extremely flexible framework to perform

such optimizations using the genetic algorithm (GA) introduced by Wager and Nichols [6]

and improved by Kao et al. [4]. Our Python implementation improves on many aspects of

existing solutions, including higher parameterization, API availability, and detailed documen-

tation. Because of its modular structure, our implementation is highly adaptable to specific

use cases in both human and animal fMRI. Nevertheless, we also provide an easy to use de-

fault algorithm, with widely applicable and properly cited presets. The implementation allows

full model (design matrix construction and covariance matrix computation) as well as fitness

measure specification.
Cheumatopsyche infascia Martynov 1934
Creators: name: Kong, Sun-Jin Park and Dongsoo
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Hydropsychidae
Cheumatopsyche
Cheumatopsyche infascia

description: 7. Cheumatopsyche infascia Martynov, 1934
 ãű꼬마ẃ날AE래
 Cheumatopsyche infascia Martynov, 1934, Tabl analyt Faune URSS 13, 283 - 284, 341, f 205a - c; Botosaneanu 1970, 297, pl 20 f 1, N (NGW, PB), M; Kobayashi 1989, 3, S (GN), F; Mey 1989, 302, N (PB), M, F; Kumanski 1992, 66, N (HHB, HHN, NGW, PN, PY), M, F; Hwang and Yoon 1996, 9, f 5, 8i - j, S (CB, CN, GG, GW), M, F; Hwang 2006, 64 - 65, f 151 - 155, S (CB, CN, GB, GG, GW, JN), M, F; Oláh et al. 2018, 109 - 110, N (PB), M.
description: Published as part of Kong, Sun-Jin Park and Dongsoo, 2020, A checklist of Trichoptera (Insecta) of the Korean Peninsula, pp. 288-323 in Journal of Species Research 9 (3) on page 291, DOI: 10.12651/JSR.2020.9.3.288, http://zenodo.org/record/13141222
Additional file 2 of A high-volume study on the impact of diabetes mellitus on clinical outcomes after surgical and percutaneous cardiac interventions
Creators: name: Slingerland, S. R.
name: Schulz, D. N.
name: van Steenbergen, G. J.
name: Soliman-Hamad, M. A.
name: Kisters, J. M. H.
name: Timmermans, M.
name: Teeuwen, K.
name: Dekker, L.
name: van Veghel, D.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Virology

description: Supplementary Material 2
Isselicrininae Klikushin 1977
Creators: name: Roux, Nadia Améziane Marc Eléaume Michel
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Crinoidea
Isocrinida
Balanocrinidae

description: Subfamily Isselicrininae Klikushin, 1977
C r yptosynarthry at Br1 + 2, proximal cirri markedly downwards, alternicirration. Included genera: Praeisselicrinus, Isselicrinus, and Panglaocrinus gen. nov .. Late Cretaceous–Recent.
description: Published as part of Roux, Nadia Améziane Marc Eléaume Michel, 2024, Classification of Isocrinida (Echinodermata: Crinoidea) with the description of a new extant genus and species from the western Pacific, pp. 994-1012 in Zoological Journal of the Linnean Society (Zool. J. Linn. Soc.) (Zool. J. Linn. Soc.) 200 (4) on page 1010, DOI: 10.1093/zoolinnean/zlad101, http://zenodo.org/record/11240631
Hydropsyche dolosa Banks 1939
Creators: name: Kong, Sun-Jin Park and Dongsoo
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Hydropsychidae
Hydropsyche
Hydropsyche dolosa

description: 10. Hydropsyche dolosa Banks, 1939 날ǔẃ날AE래
 Hydropsyche dolosa Banks, 1939, Bull Mus Comp Zool Harvard 85, 489, pl 9 f 93, 101, 105 - 106; Kumanski 1992, 65 - 66, N (PY), M, F.
 Remarks. This species was synonymized with Hydropsyche formosana Ulmer, 1911 by Mey (1999b), but treated as a distinct species by Malicky and Chantaramongkol (2000) and Yang et al. (2016).
description: Published as part of Kong, Sun-Jin Park and Dongsoo, 2020, A checklist of Trichoptera (Insecta) of the Korean Peninsula, pp. 288-323 in Journal of Species Research 9 (3) on page 291, DOI: 10.12651/JSR.2020.9.3.288, http://zenodo.org/record/13141222
Human leukocyte antigens and haplotypes allow for prognostic classification of HNSCC patients
Creators: name: Wichmann, Gunnar
name: Dietz, Andreas
name: Wiegand, Susanne
Publisher: name: Proceedings on Cancer-Immuno-Oncology
Year: 2018

description: Background: Genetic instability generates somatic mutations which are mostly controlled by the immune system but defects in the T-cell system accompany higher cancer incidences. T-cell responses to tumor-associated antigens (TAA) including neoantigens, oncogenes and viral proteins depend on binding and proper presentation of TAA-derived peptides by human leukocyte antigen (HLA) class I (HLA-A, B, Cw) and II proteins (DR, DQ, DP). Particular HLA antigens and their combinations (haplotypes) may facilitate immune escape of cancer caused by their inability to bind and present such peptides to T cells. We recently demonstrated a link between HLA alleles and haplotypes (HLA-traits) and the development of head and neck squamous cell carcinoma (HNSCC) and varying progression-free survival (PFS) of HNSCC patients. Methods: We developed a HLA-score abstracting from complexity of HLA-typing results to facilitate potential use of HLA-associated hazard ratios (HR) for prognostic stratification. The HR for PFS of 8 HLA-traits shown to be independent predictors (Pi) of PFS in a test cohort (TC) of 90 patients[1] were used to build the HLA-score based on the Pi-associated HR.[2] Crude ln-transformed HR of the alleles HLA-B*13 (2), B*35 (1), B*51 (2), DQB1*06 (1), homozygous Cw (1), homozygous DRB4 (2), and haplotypes A*01/B*08 (-6) and B*08/C*07 (4), were summed up to define the individual patient’s HLA-score. Results: Receiver operating characteristic (ROC; P = 0.0000034) and Kaplan-Meier curves for PFS demonstrated the prognostic significance of the HLA-score (AUC=0.750, CI 95% 0.665-0.836; 70/90 patients in TC with HLA-Score >0 had reduced PFS (P=0.001)[2]. Applying the same classifier (HLA-score >0) to an independent validation cohort (iVC) of 32 DeLOS-II patients confirmed these findings by demonstrating reduced PFS of 25/32 patients (P=0.040)[2). Recent research demonstrates that HLA-traits constitute critical Pi in other cancers (e.g. melanoma) and predicts response to immune-checkpoint inhibitors.
Conclusion: Considering HLA for prognostic stratification could reduce outcome variance in clinical trials. The HLA-score may facilitate the use of genetic information from HLA-typing.


References
[1] Wichmann et al., Oral Oncol. 2017; 69: 115-127;
http://dx.doi.org/10.1016/j.oraloncology.2017.04.017.
[2] Wichmann et al., Front. Oncol. 2018; 8: 168;
http://dx.doi.org/10.3389/fonc.2018.00168.
description: Proceedings on Cancer-Immuno-Oncology, Vol 1 No 1 (2018)
Additional file 3 of A high-volume study on the impact of diabetes mellitus on clinical outcomes after surgical and percutaneous cardiac interventions
Creators: name: Slingerland, S. R.
name: Schulz, D. N.
name: van Steenbergen, G. J.
name: Soliman-Hamad, M. A.
name: Kisters, J. M. H.
name: Timmermans, M.
name: Teeuwen, K.
name: Dekker, L.
name: van Veghel, D.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Virology

description: Supplementary Material 3