cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
γ-Cyclodextrin hydrogel for the sustained release of josamycin for potential ocular application
Creators: name: Huling, Jennifer
name: Oschatz, Stefan
name: Lange, Helge
name: Sterenczak, Katharina Anna
name: Stahnke, Thomas
name: Markhoff, Jana
name: Stachs, Oliver
name: Möller, Steffen
name: Undre, Nasrullah
name: Peil, Anita
name: Jünemann, Anselm
name: Grabow, Niels
name: Fuellen, Georg
name: Eickner, Thomas
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biophysics
Space Science
Medicine
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: Glaucoma is the leading cause of blindness worldwide. However, its surgical treatment, in particular via trabeculectomy, can be complicated by fibrosis. In current clinical practice, application of the drug, Mitomycin C, prevents or delays fibrosis, but can lead to additional side effects, such as bleb leakage and hypotony. Previous in silico drug screening and in vitro testing has identified the known antibiotic, josamycin, as a possible alternative antifibrotic medication with potentially fewer side effects. However, a suitable ocular delivery mechanism for the hydrophobic drug to the surgical site does not yet exist. Therefore, the focus of this paper is the development of an implantable drug delivery system for sustained delivery of josamycin after glaucoma surgery based on crosslinked γ-cyclodextrin. γ-Cyclodextrin is a commonly used solubilizer which was shown to complex with josamycin, drastically increasing the drug’s solubility in aqueous solutions. A simple γ-cyclodextrin crosslinking method produced biocompatible hydrogels well-suited for implantation. The crosslinked γ − cyclodextrin retained the ability to form complexes with josamycin, resulting in a 4-fold higher drug loading efficiency when compared to linear dextran hydrogels, and prolonged drug release over 4 days.
Constitutive model for time-dependent flows of shear-thickening suspensions
Creators: name: Gillissen, Jurriaan J. J.
name: Ness, Chris
name: Peterson, Joseph D.
name: Wilson, Helen J.
name: Cates, Michael E.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We develop a tensorial constitutive model for dense, shear-thickening particle suspensions subjected to time-dependent flow. Our model combines a recently proposed evolution equation for the suspension microstructure in rate-independent materials with ideas developed previously to explain the steady flow of shear-thickening ones, whereby friction proliferates among compressive contacts at large particle stresses. We apply our model to shear reversal, and find good qualitative agreement with particle-level, discrete-element simulations whose results we also present.
description: 6 pages, 4 figures
General Theorems on Decoherence in the Thermodynamic Limit
Creators: name: Frasca, Marco
Publisher: name: arXiv
Year: 2002
Subjects: subject: Quantum Physics (quant-ph)
subject: Condensed Matter (cond-mat)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We extend the results on decoherence in the thermodynamic limit [M. Frasca, Phys. Lett. A {\bf 283}, 271 (2001)] to general Hamiltonians. It is shown that N independent particles, initially properly prepared, have a set of observables behaving classically in the thermodynamic limit. This particular set of observables is then coupled to a quantum system that in this way decoheres so to have the density matrix in a mixed form. This gives a proof of the generality of this effect.
description: 8 pages, no figures. Version accepted by Physics Letters A
Recurvaria nanella
Creators: name: Junnilainen, Jari
name: Karsholt, Ole
name: Nupponen, Kari
name: Kaitila, Jari-Pekka
name: Nupponen, Timo
name: Olschwang, Vladimir
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Gelechiidae
Recurvaria
Recurvaria nanella

description: Recurvaria nanella (Denis & Schiffermüller, 1775)
Kuvandyk 02.VIII.2000 (1♂).
 Distribution. Widely distributed in Europe, absent from the north. Outside Europe in Turkey, Near East, N Africa (including Egypt), the Caucasus, Transcaucasia, Kazakhstan and SE Siberia. Recorded also from N America where probably introduced.
description: Published as part of Junnilainen, Jari, Karsholt, Ole, Nupponen, Kari, Kaitila, Jari-Pekka, Nupponen, Timo & Olschwang, Vladimir, 2010, The gelechiid fauna of the southern Ural Mountains, part II: list of recorded species with taxonomic notes (Lepidoptera: Gelechiidae) 2367, pp. 1-68 in Zootaxa 2367 (1) on page 28, DOI: 10.11646/zootaxa.2367.1.1, http://zenodo.org/record/10093655
title: Uncommon Stranding Event of Bottlenose Dolphins (Tursiops truncatus) in San Diego, California (October 2015)
Creators: name: Danil, Kerri
Publisher: name: Southwest Fisheries Science Center (U.S.)
Year: 2021

description: NOAA technical memorandum NMFS NOAA-TM-NMFS-SWFSC ; 641
Relationship between neurocognition and theory of mind as a function of symptomatic profile in schizophrenia: results from the national FACE-SZ cohort
Creators: name: Rambeau, Sébastien
name: Del Goleto, Sarah
name: Pignon, Baptiste
name: Lajnef, Mohamed
name: Petrucci, Jean
name: Szöke, Andreï
name: Fond, Guillaume
name: Lançon, Christophe
name: Dorey, Jean-Michel
name: Rey, Romain
name: Garbisson, Amandine
name: Capdevielle, Delphine
name: Leignier, Sylvain
name: Dubreucq, Julien
name: Mallet, Jasmina
name: Dubertret, Caroline
name: Urbach, Mathieu
name: Brunet-Gouet, Eric
name: Aouizerate, Bruno
name: Misdrahi, David
name: Zinetti-Bertschy, Anna
name: Clauss, Julie
name: Llorca, Pierre-Michel
name: Chereau, Isabelle
name: Leboyer, Marion
name: Roux, Paul
name: Schürhoff, Franck
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: Deficits in theory of mind (ToM) can vary depending on the predominant schizophrenia symptoms, and though most neurocognitive functions are involved in ToM, all may not be associated with the same symptoms. With consideration to the relationships between symptoms, neurocognition and ToM, the aim of the present study is to identify the neurocognitive functions influencing ToM capacities according to symptomatic profile. The study is based on a sample of 124 adults with schizophrenia from a French national cohort. Patients were divided into two groups according to their scores on the five Wallwork factors of the Positive and Negative Syndrome Scale using hierarchical clustering before carrying out multivariable analyses. The “disorganised group” (n = 89) showed high scores on the disorganised factor, and had a ToM associated with reasoning, visual recognition and speed of processing. The “positive group” (n = 35) showed high scores on the positive and depressive factors, and had a ToM associated with working memory. These results suggest that neurocognitive predictors of ToM in schizophrenia are different according to the predominant clinical dimension, thus refining our knowledge of the relationship between symptoms, neurocognition and ToM, and acknowledging their status as important predictors of patients’ functional status.
Dispersion relation of the $ρ$ meson in hot/dense nuclear matter
Creators: name: Chen, Ji-Sheng
name: Li, Jia-Rong
name: Zhuang, Peng-Fei
Publisher: name: arXiv
Year: 2002
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The dispersion relation of $ρ$ meson in both timelike and spacelike regimes in hot and dense nuclear medium is analyzed and compared with $σ$ meson based on the quantum hadrodynamics model. The pole and screening masses of $ρ$ and $σ$ are discussed. The behavior of screening mass of $ρ$ is different from that of $σ$ due to different Dirac- and Fermi-sea contributions at finite temperature and density.
description: 4 pages, 3 figures, identical to published version
Sensitivity of EDM experiments in paramagnetic atoms and molecules to hadronic CP violation
Creators: name: Flambaum, V. V.
name: Pospelov, M.
name: Ritz, A.
name: Stadnik, Y. V.
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: Experiments searching for the electric dipole moment (EDM) of the electron $d_e$ utilise atomic/molecular states with one or more uncompensated electron spins, and these paramagnetic systems have recently achieved remarkable sensitivity to $d_e$. If the source of $CP$ violation resides entirely in the hadronic sector, the two-photon exchange processes between electrons and the nucleus induce $CP$-odd semileptonic interactions, parametrised by the Wilson coefficient $C_{SP}$, and provide the dominant source of EDMs in paramagnetic systems instead of $d_e$. We evaluate the $C_{SP}$ coefficients induced by the leading hadronic sources of $CP$ violation, namely nucleon EDMs and $CP$-odd pion-nucleon couplings, by calculating the nucleon-number-enhanced $CP$-odd nuclear scalar polarisability, employing chiral perturbation theory at the nucleon level and the Fermi-gas model for the nucleus. This allows us to translate the ACME EDM limits from paramagnetic ThO into novel independent constraints on the QCD theta term $|\bar θ| < 3 \times 10^{-8}$, proton EDM $|d_p| < 2 \times 10^{-23}\,e\,{\rm cm}$, isoscalar $CP$-odd pion-nucleon coupling $|\bar g^{(1)}_{πNN}| < 4 \times 10^{-10}$, and colour EDMs of quarks $|\tilde d_u - \tilde d_d| < 2 \times 10^{-24}\,{\rm cm}$. We note that further experimental progress with EDM experiments in paramagnetic systems may allow them to rival the sensitivity of EDM experiments with neutrons and diamagnetic atoms to these quantities.
description: 7 pages, 3 figures, version accepted for publication in Physical Review D
ASCA View of the Supernova Remnant Gamma Cygni (G78.2+2.1): Bremsstrahlung X-ray Spectrum from Loss-flattened Electron Distribution
Creators: name: Uchiyama, Yasunobu
name: Takahashi, Tadayuki
name: Aharonian, Felix
name: Mattox, John
Publisher: name: arXiv
Year: 2002
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We perform X-ray studies of the shell-type supernova remnant (SNR) gamma-Cygni associated with the brightest EGRET unidentified source 3EG J2020+4017. In addition to the thermal emissions with characteristic temperature of kT = 0.5-0.9 keV, we found an extremely hard X-ray component from several clumps localized in the northern part of the remnant. This component is described by a power-law with a photon index of 0.8-1.5. Both the absolute flux and the spectral shape of the nonthermal X-rays cannot be explained by the synchrotron or inverse-Compton mechanisms. We argue that the unusually hard X-ray spectrum can be naturally interpreted in terms of nonthermal bremsstrahlung from Coulomb-loss-flattened electron distribution in dense environs with the gas density about 10 to 100 cm^-3 . For given spectrum of the electron population, the ratio of the bremsstrahlung X- and gamma-ray fluxes depends on the position of the ``Coulomb break'' in the electron spectrum. The bulk of gamma-rays detected by EGRET would come from the radio-bright and X-ray dim cloud at southeast, where very dense gas and strong magnetic field would illuminate the cloud in the radio and gamma-ray bands, but suppress the bremsstrahlung X-ray emission due to the shift of the ``Coulomb break'' in the electron spectrum towards higher energies.
description: 14 pages, 8 figures, emulateapj5, accepted for publication in the Astrophysical Journal
Parachronistis albiceps
Creators: name: Junnilainen, Jari
name: Karsholt, Ole
name: Nupponen, Kari
name: Kaitila, Jari-Pekka
name: Nupponen, Timo
name: Olschwang, Vladimir
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Gelechiidae
Parachronistis
Parachronistis albiceps

description: Parachronistis albiceps (Zeller, 1839)
Arkaim 14–19. VI.1996; Berlin 30. VI –02. VII.1997; Ekaterinburg 10–15. VII.2003; Kuvandyk 13–16. VI.1998; Miass 26–28. VI.1997; Verbljushka 10–12.VI.1998, 27.VI.2003. A total of 12 exx.
 Distribution. Widely distributed in Europe, apart from northernmost parts. Outside Europe known from S Siberia (Transbaikalia, Altai), The Russian Far East and Korea.
description: Published as part of Junnilainen, Jari, Karsholt, Ole, Nupponen, Kari, Kaitila, Jari-Pekka, Nupponen, Timo & Olschwang, Vladimir, 2010, The gelechiid fauna of the southern Ural Mountains, part II: list of recorded species with taxonomic notes (Lepidoptera: Gelechiidae) 2367, pp. 1-68 in Zootaxa 2367 (1) on page 29, DOI: 10.11646/zootaxa.2367.1.1, http://zenodo.org/record/10093655
Evolution of quantum systems with a scaling type of time-dependent Hamiltonians
Creators: name: Samaj, L.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Quantum Physics (quant-ph)
subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: We introduce a new class of quantum models with time-dependent Hamiltonians of a special scaling form. By using a couple of time-dependent unitary transformations, the time evolution of these models is expressed in terms of related systems with time-independent Hamiltonians. The mapping of dynamics can be performed in any dimension, for an arbitrary number of interacting particles and for any type of the scaling interaction potential. The exact solvability of a "dual" time-independent Hamiltonian automatically means the exact solvability of the original problem with model time-dependence.
description: 9 pages
Additional file 13 of HBV genome-enriched single cell sequencing revealed heterogeneity in HBV-driven hepatocellular carcinoma (HCC)
Creators: name: Wang, Wenhui
name: Chen, Yan
name: Wu, Liang
name: Zhang, Yi
name: Yoo, Seungyeul
name: Chen, Quan
name: Liu, Shiping
name: Hou, Yong
name: Chen, Xiao-ping
name: Chen, Qian
name: Zhu, Jun
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 13: Table S12. Integration hot spots supported by known fusion events. Hot spot genes are reported as cancer fusion gene by both cancer cell line and TCGA for different kinds of cancers.
title: Eastern Georges Bank Cod
Creators: name: Canada. Department of Fisheries and Oceans.  United States. National Marine Fisheries Service.  Northeast Fisheries Science Center (U.S.)
Publisher: name: Canada. Department of Fisheries and Oceans.  United States. National Marine Fisheries Service.  Northeast Fisheries Science Center (U.S.)
Year: 2020

description: TRAC Status Report 2020/01
Agnippe pseudolella
Creators: name: Junnilainen, Jari
name: Karsholt, Ole
name: Nupponen, Kari
name: Kaitila, Jari-Pekka
name: Nupponen, Timo
name: Olschwang, Vladimir
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Gelechiidae
Agnippe
Agnippe pseudolella

description: Agnippe pseudolella (Christoph, 1888)
Figs. 29 & 30
Burannoe 18.VIII.2006 (1♀); Chalk Hills 22.VIII.2006 (1♂). Genitalia slide: K. Nupponen prep. no. 1/ 19.X.2008.
 Other material studied: Turkey, Aksehir 30 km SW, Sultan Daglari, 1500 m, several exx. 29.V.1997, K. Nupponen & J. Junnilainen leg. Genitalia slides: J. Junnilainen prep. no. 02011903, 02011907, 02012006.
 Distribution. Russia (S Ural, Lower Volga), Kazakhstan, Turkey.
 Remarks. The genus Evippe Chambers, 1873 was synonymized with Agnippe Chambers, 1872 (Lee & Brown 2008), and E. pseudolella (Christoph, 1888) was transferred to Agnippe. Lita cephalella Caradja, 1920 was described from Uralsk in Kazakhstan, and synonymized with A. pseudolella by Park (1996: 63).
description: Published as part of Junnilainen, Jari, Karsholt, Ole, Nupponen, Kari, Kaitila, Jari-Pekka, Nupponen, Timo & Olschwang, Vladimir, 2010, The gelechiid fauna of the southern Ural Mountains, part II: list of recorded species with taxonomic notes (Lepidoptera: Gelechiidae) 2367, pp. 1-68 in Zootaxa 2367 (1) on page 29, DOI: 10.11646/zootaxa.2367.1.1, http://zenodo.org/record/10093655
title: Update of Allocation Shares for Canada and the USA of the Transboundary Resources of Atlantic Cod, Haddock, and Yellowtail Flounder on Georges Bank Through Fishing Year 2021
Creators: name: Barrett, M. A.
Publisher: name: Canada. Department of Fisheries and Oceans.  United States. National Marine Fisheries Service.  Northeast Fisheries Science Center (U.S.)
Year: 2020

description: TRAC Reference Document 2020/01
The Impact of Rising Energy Costs on Agricultural Production and the Regional Economy: A Case Stufy of Saskatchewan
Creators: name: Kulshreshtha, S. N.
name: Tewari, D. D.
name: Johnson, T. G.
name: Kulshreshtha, S. N.
name: Tewari, D. D.
name: Johnson, T. G.
Publisher: name: Unknown
Year: 1983
Subjects: Agribusiness
Resource /Energy Economics and Policy

description: Higher energy prices, particularly those for crude oil, have been a worldwide reality since the creation of the Organization of Petroleum Exporting Countries (OPEC). Since many of the inputs in agriculture are either petroleum products or largely petroleum based, the agricultural industry has faced an unprecedented rise in input costs. Canada is no exception to this trend. By the third quarter of 1981, fertilizer prices had increased to 387.1 percent of their 1971 price level. Similarly, the price of fuel jumped to 279.3 percent of its 1971 level. Trends in the future may be even more dramatic. According to the Alberta Agreement,2 the price of oil will increase from $21.25 per barrel in October 1981, to $57. 75 by October 1986--an increase of 172 percent. For Saskatchewan, primarily because of the predominance of grains in the total agricultural production, 3 rising energy costs appear to be a threat to the future viability of the industry.
ELITES AND POLITICS: WHO GOVERNS US? Measuring and comparing species of capital in the Chilean political elite, 1990-2010
Creators: name: Garrido-Vergara, Luis Abelardo
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: species of capital
political elites
parliament
ministers
Chile

description: In this study, the Bourdieusian concepts of species of capital and habitus are applied to the field of elites. Although sociological research has examined the reproduction of Chile’s elites, there is little empirical evidence as to how different forms of capital operate within them. Based on a survey of the country’s elites, this thesis examines the effect of different forms of capital (cultural, social and political) on access to strategic positions in the legislative and executive branches of government. It focuses on the political elite in the 20 years between 1990, when military dictator Augusto Pinochet handed over the presidency to Patricio Aylwin, his democratically elected successor, and 2010, the end of President Michelle Bachelet’s first government. At least three points are germane to this analysis: (1) understanding the nature of the party elites during the political transition; (2) describing and explaining the main aspects of the party elites’ background and social resources, including their family networks (independent variables); and (3) exploring the effect of those variables on individuals’ chances of achieving strategic positions in the political field, comparing the legislative and executive branches as represented by deputies and ministers (dependent variable). The data was obtained through a survey of 386 members of the nucleus of the Chilean political elite, enquiring about their social, academic and family background, social resources and professional and political careers, among other topics. The empirical analysis includes network analysis of family capital and six logit models for three periods: 1990-2000, 2000-2010 and 1990-2010. The results indicate that age, gender and variables related to cultural, social and political capital are relevant for becoming both a deputy and a minister, but with opposite effects. Only family capital has a significant effect in the same direction for the two branches of government. However, the effects of the variables vary when differentiating by period. The originality of the research lies in the collection and analysis of new empirical data that throws light on a subject of longstanding speculation .
description: This doctoral research was supported by the FONDECYT project entitled “Political elites in Chile: Sociology of the governmental, parliamentary and party staff (1990-2010)” (Project Nº 1100877). Lead researcher: Alfredo Joignant Rondón. This PhD thesis will be published by Palgrave Macmillan
The gravitational torque of bars in optically unbarred and barred galaxies
Creators: name: Block, D. L.
name: Puerari, I.
name: Knapen, J. H.
name: Elmegreen, B. G.
name: Buta, R.
name: Stedman, S.
name: Elmegreen, D. M.
Publisher: name: arXiv
Year: 2001
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The relative bar torques for 45 galaxies observed at $K$- band with the 4.2m William Herschel Telescope are determined by transforming the light distributions into potentials and deriving the maximum ratios of the tangential forces relative to the radial forces. The results are combined with the bar torques for 30 other galaxies determined from our previous $K$-band survey (Buta & Block 2001). Relative bar torques determine the degree of spiral arm forcing, gas accretion, and bar evolution. They differ from other measures of bar strength, such as the relative amplitude of the bar determined photometrically, because they include the bulge and other disk light that contributes to the radial component of the total force. If the bulge is strong and the radial forcing large, then even a prominent bar can have a relatively weak influence on the azimuthal motions in the disk. Here we find that the relative bar torque correlates only weakly with the optical bar type listed in the Revised Shapley-Ames and de Vaucouleurs systems. In fact, some classically barred galaxies have weaker relative bar torques than classically unbarred galaxies. The optical class is a poor measure of azimuthal disk forcing for two reasons: some infrared bars are not seen optically, and some bars with strong bulges have their azimuthal forces so strongly diluted by the average radial force that they exert only small torques on their disks. The Hubble classification scheme poorly recognizes the gravitational influence of bars. Applications of our bar torque method to the high-redshift universe are briefly discussed.
description: 9 pages, 9 embedded postscript figures. Accepted for publication in A&A, May 30, 2001. Original high-quality figures can be obtained from ftp://ftp.ing.iac.es/pub/outgoing/knapen/Block/
Factors associated with the number of clinical pharmacy recommendations: findings from an observational study in geriatric inpatients
Creators: name: Van Der Linden, Lorenz
name: Hias, Julie
name: Karolien Walgraeve
name: Loyens, Silke
name: Flamaing, Johan
name: Spriet, Isabel
name: Tournoy, Jos
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Medicine
subject: Biotechnology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objectives: Drug-related problems are prevalent in older inpatients and can be reduced by providing clinical pharmacy (CP) services. Details concerning implementation in clinical practice are frequently lacking. The aim was to describe the output of one such CP program and to identify factors associated with CP recommendations. Methods: A CP program was installed at three acute geriatric wards in a teaching hospital. A convenience sample was collected, consisting of inpatients who received a CP consultation at discharge. Medical conditions, patient demographics, and drug use were evaluated retrospectively. Number and type of the CP recommendations were determined. A Poisson regression analysis was performed to determine factors associated with the number of CP recommendations. Results: A cohort of 524 patients, aged 85 (interquartile range (IQR): 82–89) years was included. On admission, 10.31 (standard deviation: 4.49) drugs were taken. Three (IQR: 2–4) CP recommendations were provided per patient, of which 70.2% targeted drug discontinuation. A model was derived, containing the following factors: number of drugs on admission (incidence rate ratio (IRR): 1.063; 95% confidence interval (CI): 1.052–1.074), number of previous contacts with the geriatric department (IRR: 0.869; 95%CI: 0.816–0.926), presence of left-ventricular dysfunction (IRR: 1.179, 95% CI: 1.023–1.360), the number of new drugs (IRR: 1.046; 95% CI: 1.021–1.071) and use of colecalciferol (IRR: 1.22; 95% CI: 1.088–1.367). Conclusions: Five factors were associated with the number of CP recommendations at discharge. This could allow for further patient stratification to increase the efficiency of the CP program.
Ab Initio Treatment of Collective Correlations and the Neutrinoless Double Beta Decay of $^{48}$Ca
Creators: name: Yao, J. M.
name: Bally, B.
name: Engel, J.
name: Wirth, R.
name: Rodríguez, T. R.
name: Hergert, H.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Working with Hamiltonians from chiral effective field theory, we develop a novel framework for describing arbitrary deformed medium-mass nuclei by combining the in-medium similarity renormalization group with the generator coordinate method. The approach leverages the ability of the first method to capture dynamic correlations and the second to include collective correlations without violating symmetries. We use our scheme to compute the matrix element that governs the neutrinoless double beta decay of $^{48}$Ca to $^{48}$Ti, and find it to have the value $0.61$, near or below the predictions of most phenomenological methods. The result opens the door to ab initio calculations of the matrix elements for the decay of heavier nuclei such as $^{76}$Ge, $^{130}$Te, and $^{136}$Xe.
description: 6 pages, 4 figures and 1 table. supplementary material included. version to be published
Développement de l'écotourisme dans la région du Triangle Bleu, Littoral Nord-Est de Madagascar: Collecte de données auprès de voyagistes en Suisse
Creators: name: Mathez-Stiefel, Sarah-Lan
Publisher: name: University of Bern
publisherIdentifier: https://ror.org/02k7v4d05
publisherIdentifierScheme: ROR
Year: 2005

description: Rapport des enquêtes menées en Suisse quant au secteur de l'écotourisme: tendances, entretiens auprès des voyagistes en Suisses et des touristes à Madagascar.
Photo-crosslinkable polyester microneedles as sustained drug release systems toward hypertrophic scar treatment
Creators: name: Szabó, Anna
name: De Decker, Ignace
name: Semey, Sam
name: Claes, Karel E.Y.
name: Blondeel, Phillip
name: Monstrey, Stan
name: Van Dorpe, Jo
name: Van Vlierberghe, Sandra
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Burn injuries can result in a significant inflammatory response, often leading to hypertrophic scarring (HTS). Local drug therapies e.g. corticoid injections are advised to treat HTS, although they are invasive, operator-dependent, extremely painful and do not permit extended drug release. Polymer-based microneedle (MN) arrays can offer a viable alternative to standard care, while allowing for direct, painless dermal drug delivery with tailorable drug release profile. In the current study, we synthesized photo-crosslinkable, acrylate-endcapped urethane-based poly(ε-caprolactone) (AUP-PCL) toward the fabrication of MNs. Physico-chemical characterization (1H-NMR, evaluation of swelling, gel fraction) of the developed polymer was performed and confirmed successful acrylation of PCL-diol. Subsequently, AUP-PCL, and commercially available PCL-based microneedle arrays were fabricated for comparative evaluation of the constructs. Hydrocortisone was chosen as model drug. To enhance the drug release efficiency of the MNs, Brij®35, a nonionic surfactant was exploited. The thermal properties of the MNs were evaluated via differential scanning calorimetry. Compression testing of the arrays confirmed that the MNs stay intact upon applying a load of 7 N, which correlates to the standard dermal insertion force of MNs. The drug release profile of the arrays was evaluated, suggesting that the developed PCL arrays can offer efficient drug delivery for up to two days, while the AUP-PCL arrays can provide a release up to three weeks. Finally, the insertion of MN arrays into skin samples was performed, followed by histological analysis demonstrating the AUP-PCL MNs outperforming the PCL arrays upon providing pyramidical-shaped perforations through the epidermal layer of the skin. AUP-PCL MN arrays provide long-term transdermal drug delivery of hydrocortisone AUP-PCL-based MN arrays provide superior drug release profiles compared to PCL MNs Effective skin penetration AUP-PCL-based MNs on skin was achieved
Teleiodes vulgella
Creators: name: Junnilainen, Jari
name: Karsholt, Ole
name: Nupponen, Kari
name: Kaitila, Jari-Pekka
name: Nupponen, Timo
name: Olschwang, Vladimir
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Gelechiidae
Teleiodes
Teleiodes vulgella

description: Teleiodes vulgella (Denis & Schiffermüller, 1775)
Arkaim 14–19.VI.1996; Bajmak 17.VI.1998; Kuvandyk 13–16.VI.1998; Miass 26–29.VI.1996, 19.VI.1998, 06.VII.2003; Moskovo 22–23.VI.1996, 18–19.VI.1998, 11–12.VII.1998. A total of 18 exx. Three genitalia preparations (males) preserved in glycerol.
 Distribution. Widely distributed in Europe, less common in the south, eastwards to S Ural and the Volga region.
description: Published as part of Junnilainen, Jari, Karsholt, Ole, Nupponen, Kari, Kaitila, Jari-Pekka, Nupponen, Timo & Olschwang, Vladimir, 2010, The gelechiid fauna of the southern Ural Mountains, part II: list of recorded species with taxonomic notes (Lepidoptera: Gelechiidae) 2367, pp. 1-68 in Zootaxa 2367 (1) on pages 29-30, DOI: 10.11646/zootaxa.2367.1.1, http://zenodo.org/record/10093655
Teleiodes wagae
Creators: name: Junnilainen, Jari
name: Karsholt, Ole
name: Nupponen, Kari
name: Kaitila, Jari-Pekka
name: Nupponen, Timo
name: Olschwang, Vladimir
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Gelechiidae
Teleiodes
Teleiodes wagae

description: Teleiodes wagae (Nowicki, 1860)
Arkaim 14–19.VI.1996 (1♂).
 Distribution. Locally recorded through Europe, apart from northernmost parts. Eastwards locally throughout Siberia.
description: Published as part of Junnilainen, Jari, Karsholt, Ole, Nupponen, Kari, Kaitila, Jari-Pekka, Nupponen, Timo & Olschwang, Vladimir, 2010, The gelechiid fauna of the southern Ural Mountains, part II: list of recorded species with taxonomic notes (Lepidoptera: Gelechiidae) 2367, pp. 1-68 in Zootaxa 2367 (1) on page 30, DOI: 10.11646/zootaxa.2367.1.1, http://zenodo.org/record/10093655
Chandra Observations of Unresolved X-ray Sources around two Clusters of Galaxies
Creators: name: Molnar, S. M.
name: Hughes, J. P.
name: Donahue, M.
name: Joy, M.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We have searched for unresolved X-ray sources in the vicinity of two rich clusters of galaxies: Abell 1995 (A1995) and MS 0451.6-0305 (MS0451), using the Chandra X-ray observatory. We detected significantly more unresolved sources around A1995 than expected based on the number of X-ray sources to the same flux limit detected in deep \CHANDRA observations of blank fields. Previous studies have also found excess X-ray sources in the vicinity of several nearby clusters of galaxies using \ROSAT$ $, and recently in more distant ($z ~ 0.5$) clusters (RXJ0030 and 3C295) using Chandra. In contrast, we detect only 14 unresolved X-ray sources near MS0451, which is consistent with the number expected from a cluster-free background. We determine the luminosity functions of the extra sources under the assumption that they are at the distance of their respective clusters. The characteristic luminosity of the extra sources around A1995 must be an order of magnitude fainter than that of the extra sources around RXJ0030 and 3C295. The apparent lack of extra sources around MS0451 is consistent with its greater distance and the same characteristic luminosity as the A1995 sources. Hardness ratios suggest that, on average, the extra sources in A1995 may have harder spectra than those of RXJ0030 and 3C295. These results indicate that different classes of objects may dominate in different clusters, perhaps depending on the formation history and/or dynamical state of the accompanying cluster.
description: LateX, 4 pages, 2 figures, 2 tables, In press: Astrophysical Journal Letters, Volume 573, 2002, July 10
Non-Singlet Structure Functions at Three Loops: Fermionic Contributions
Creators: name: Moch, S.
name: Vermaseren, J. A. M.
name: Vogt, A.
Publisher: name: arXiv
Year: 2002
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We compute the fermionic (n_f) contributions to the flavour non-singlet structure functions in unpolarized electromagnetic deep-inelastic scattering at third order of massless perturbative QCD. Complete results are presented for the corresponding nf-parts of the three-loop anomalous dimension and the three-loop coefficient functions for the structure functions F_2 and F_L. Our results agree with all partial and approximate results available in the literature. The present calculation also facilitates a complete determination of the threshold-resummation parameters B_2 and D_2^DIS of which only the sum was known so far, thus completing the information required for the next-to-next-to-leading logarithmic resummation. We find that D_2^DIS vanishes in the MSbar scheme.
description: 20 pages, LaTeX, 1 eps-figure
Additional file 2 of Sand supplementation favors tropical seagrass Thalassia hemprichii in eutrophic bay: implications for seagrass restoration and management
Creators: name: Jiang, Zhijian
name: Liu, Songlin
name: Cui, Lijun
name: He, Jialu
name: Fang, Yang
name: Premarathne, Chanaka
name: Li, Linglan
name: Wu, Yunchao
name: Huang, Xiaoping
name: Kumar, Manoj
Publisher: name: figshare
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Additional file 2: Figure S2. Voucher specimen of Thalassia hemprichii.
MOESM1 of MIENTURNET: an interactive web tool for microRNA-target enrichment and network-based analysis
Creators: name: Licursi, Valerio
name: Conte, Federica
name: Fiscon, Giulia
name: Paci, Paola
Publisher: name: figshare
Year: 2019
Subjects: subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology

description: Additional file 1 This file contains the user guide of MIENTURNET showing how the tool works and how to use it.
Research and Productivity in Grain Production in Asia: The Colonial Heritage
Creators: name: Pray, Carl E.
name: Pray, Carl E.
Publisher: name: Unknown
Year: 1983
Subjects: Crop Production/Industries
Research and Development/Tech Change/Emerging Technologies

description: Colonial agricultural research was directed mainly to. export crops rather than the major foodgrains.2 The lack of research on foodgrains is given as one of the reasons for the food shortages in the period after World War II. "Colonialism stunted indigenous agriculture by directing agricultural research only to export crops" (Lappe and Collins). This paper examines the allocation of research resources and the impact of research on productivity in South and Southeast Asia. The paper also attempts to identify the main determinants of the allocation of agricultural research resources during the colonial period.
Real-world data confirming the efficacy and safety of decitabine in acute myeloid leukaemia – results from a retrospective Belgian registry study
Creators: name: Meers, Stef
name: Bailly, Benjamin
name: Broek, Isabelle Vande
name: Malfait, Bart
name: Van Hoorenbeeck, Sandra
name: Geers, Janice
name: Braakman, Joost
name: Van Kouwenhove, Marieke
name: Doyle, Margaret
name: Diels, Joris
name: Caekelbergh, Karin
name: Chevalier, Pierre
name: Dierickx, Daan
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Hematology

description: Objectives: Currently, there is no standard treatment for patients with acute myeloid leukaemia (AML) ineligible for standard induction chemotherapy (IC). This study aimed to report real-world evidence data on the efficacy and safety of decitabine in this patient group. Methods: This study was a Belgian, retrospective, non-interventional, multicentre registry of patients ≥ 65 years, with newly-diagnosed de novo or secondary AML ineligible for IC. Patients were treated according to routine clinical practice. Overall survival (OS), progression-free survival (PFS) and transfusion independence for ≥8 consecutive weeks were evaluated. Results: Forty-five patients were enrolled, including 67% (n = 30) with secondary AML. Median OS and PFS were 7.3 months (95% CI: 2.2–11.1) and 4.1 months (95% CI: 2.1–7.6) respectively. A subpopulation analysis showed that patients treated with ≥4 cycles (n = 21) had significantly better outcomes compared to patients receiving <4 cycles (median OS 17.5 vs 1.6 months; median PFS 17.5 vs. 1.4 months). Twenty-five percent and 58% of patients that were respectively RBC or platelet transfusion-dependent at baseline became transfusion independent during treatment. Conclusion: This real-world data confirms that decitabine can lead to transfusion independence and longer OS in AML patients, particularly after administering ≥4 cycles, as indicated in the summary of product characteristics.
Multimodal Imaging of Inflammation at the Neurovascular Interface in Cerebrovascular Disease
Creators: name: Evans, Nicholas Richard
Publisher: name: Apollo - University of Cambridge Repository
Year: 2018
Subjects: Stroke
Carotid artery
Atherosclerosis

description: A carotid atherosclerotic plaque represents a nidus of inflammation mere centimetres below the blood-brain barrier. This inflammation, along with associated regions of microcalcification, are histopathological features of atheroma at risk of rupture (so-called “vulnerable plaques”) that trigger thromboembolic stroke. While conventional clinical imaging simply measures the degree of vessel stenosis, it is a crude measure that reveals little of the metabolic processes affecting plaque vulnerability. Our research demonstrates the utility of positron emission tomography (PET) using 18F-fluorodeoxyglucose (FDG) and 18F-sodium fluoride (NaF), measuring inflammation and microcalcification respectively, to identify culprit carotid atheroma in vivo, and establish how these processes influence plaque vulnerability. Furthermore, for stroke care it is the downstream thromboembolic effects upon the brain that are key. While proinflammatory conditions may increase the risk of stroke, the relationship between atheroma inflammation and the peri-infarct inflammatory response following a stroke remains poorly defined. Our work demonstrates how inflammatory activity in symptomatic carotid atheroma, measured using PET, influences both chronic small vessel disease and the evolution of lesion volume in the post-stroke period. Using metabolic imaging we can both identify vulnerable atheroma in vivo and demonstrate how these processes affect infarct evolution. We show that whilst inflammation is a generalised process, microcalcification is a focal process that may represent a point of maximum vulnerability. These results also reveal the complexity of the atheroma-brain interaction that may simultaneously trigger events while also influencing stroke evolution in the early recovery period. This has important implications for understanding pathophysiology of both atherosclerosis and stroke evolution, advancing drug-discovery, and potential clinical applications to minimise the impact from this devastating disease.
description: The Dunhill Medical Trust [RTF44/0114]
Gender Analysis of Rural Dwellers Accessibility to Free Natural Resources in Ussa Local Government Area of Taraba State, Nigeria
Creators: name: Ojo, Catherine O.
name: Nuhu, Hadiza S.
name: Igbankwe, Thomas A.
name: Ojo, Catherine O.
name: Nuhu, Hadiza S.
name: Igbankwe, Thomas A.
Publisher: name: Unknown
Year: 2013
Subjects: subject: Community/Rural/Urban Development
subject: Industrial Organization
subject: Gender
subject: free natural resources
subject: rural dwellers
subject: accessibility

description: The study analyzed gender accessibility of rural dwellers to free natural resources in Ussa Local Government Area of Taraba State, Nigeria. Primary data were collected using structured questionnaire. Sixty respondents were selected purposively to ensure that only forest resource gatherers were included in the study. Descriptive statistics were used to analyze the data collected. The findings of the study revealed that equal number of male and female respondents (41.4% each) were farmers. Also 32.4% and 31% of male and female respondents were landless. About 62% of male and 75.7% of female respondents were educated. About 87% and 90% of male and female had household sizes of over 5 persons. Men had more access to high income yielding forest resources than women. The result showed that the women took more of what they gathered home to meet household needs while a little was sold for income, while men sold most of what they collected with only little was left for home consumption. Based on the results of the study, it was recommended that increased gender based capacity building and responsibility for management of free natural resources should be encouraged among rural dwellers in order to ensure sustainability of the resources in contributing to food security and poverty alleviation among free natural resource gatherers in the study area.
Multi-shell gold nanoparticles functionalized with methotrexate: a novel nanotherapeutic approach for improved antitumoral and antioxidant activity and enhanced biocompatibility
Creators: name: Bostiog, Denisse-Iulia
name: Simionescu, Natalia
name: Coroaba, Adina
name: Marinas, Ioana C.
name: Chifiriuc, Mariana C.
name: Pircalabioru, Gratiela Gradisteanu
name: Maier, Stelian S.
name: Pinteala, Mariana
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Cancer

description: Methotrexate (MTX) is a folic acid antagonist routinely used in cancer treatment, characterized by poor water solubility and low skin permeability. These issues could be mitigated by using drug delivery systems, such as functionalized gold nanoparticles (AuNPs), known for their versatility and unique properties. This study aimed to develop multi-shell AuNPs functionalized with MTX for the improvement of MTX antitumoral, antioxidant, and biocompatibility features. Stable phosphine-coated AuNPs were synthesized and functionalized with tailored polyethylene glycol (PEG) and short-branched polyethyleneimine (PEI) moieties, followed by MTX covalent binding. Physicochemical characterization by UV–vis and Fourier-transform infrared spectroscopy (FTIR) spectroscopy, dynamic light scattering (DLS), scanning transmission electron microscopy (STEM), and X-ray photoelectron spectroscopy (XPS) confirmed the synthesis at each step. The antioxidant activity of functionalized AuNPs was determined using DPPH radical scavenging assay, ferric ions’ reducing antioxidant power (FRAP), and cupric reducing antioxidant capacity (CUPRAC) assays. Biocompatibility and cytotoxicity were assessed using MTT and LDH assays on HaCaT human keratinocytes and CAL27 squamous cell carcinoma. MTX functionalized AuNPs demonstrated enhanced antioxidant activity and a pronounced cytotoxic effect on the tumoral cells compared to their individual components, highlighting their potential for improving cancer therapy.
The Policy Strategy of Rice Straw Utilization of as Feed for Ruminants
Creators: name: Syamsu, Jasmal A.
name: Karim, Hasmida
name: Syamsu, Jasmal A.
name: Karim, Hasmida
Publisher: name: Unknown
Year: 2013
Subjects: subject: Consumer/Household Economics
subject: Institutional and Behavioral Economics
subject: Rice straw
subject: feed
subject: ruminant
subject: strategy
subject: SWOT analysis

description: As it is known that the success of the livestock business associated with feeding management support. Bantaeng District is one district that prioritizes the development of animal husbandry for the welfare of society, also this district has a great potential of agricultural waste. The tools used in the analysis is SWOT-Analysis (Strengths-Weakness-Opportunities-Threats). This matrix combines opportunities and threats which can be match to the strengths and weaknesses to produce an alternative strategy, that is SO strategy, strategy WO, WT strategy, and ST strategy. The final step is making the decision to determine which strategies are feasible alternatives and the best, with Quantitative Strategies Planning Matrix (QSPM) analysis which had previously been given an Attractiveness Score questionnaire. The result of research were the strategies require the provision of rice straw storage in groups on large livestock production centers, increased use of rice straw as a staple feed of cattle, provision of quality rice straw in the dry or drought season, supply and use of straw as animal feed with various methods of delivery and utilization.
Viscosity solutions and hyperbolic motions: a new PDE method for the $N$-body problem
Creators: name: Maderna, Ezequiel
name: Venturelli, Andrea
Publisher: name: arXiv
Year: 2019
Subjects: subject: Dynamical Systems (math.DS)
subject: Mathematical Physics (math-ph)
subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We prove for the $N$-body problem the existence of hyperbolic motions for any prescribed limit shape and any given initial configuration of the bodies. The energy level $h>0$ of the motion can also be chosen arbitrarily. Our approach is based on the construction of global viscosity solutions for the Hamilton-Jacobi equation $H(x,d_xu)=h$. We prove that these solutions are fixed points of the associated Lax-Oleinik semigroup. The presented results can also be viewed as a new application of Marchal's theorem, whose main use in recent literature has been to prove the existence of periodic orbits.
description: 43 pages, 4 figures