cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
DNA damage and reticular stress in cytotoxicity and oncotic cell death of MCF-7 cells treated with fluopsin C
Creators: name: de Lima, Luan Vitor Alves
name: da Silva, Matheus Felipe
name: Concato, Virginia Marcia
name: Rondina, Débora Berbel Lirio
name: Zanetti, Thalita Alves
name: Felicidade, Ingrid
name: Marques, Lilian Areal
name: Lepri, Sandra Regina
name: Simionato, Ane Stéfano
name: Filho, Galdino Andrade
name: Coatti, Giuliana Castello
name: Mantovani, Mário Sérgio
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Fluopsin C is an antibiotic compound derived from secondary metabolism of different microorganisms, which possesses antitumor, antibacterial, and antifungal activity. Related to fluopsin C antiproliferative activity, the aim of this study was to examine the following parameters: cytotoxicity, genotoxicity, cell cycle arrest, cell death induction (apoptosis), mitochondrial membrane potential (MMP), colony formation, and mRNA expression of genes involved in adaptive stress responses and cellular death utilizing a monolayer. In addition, a three-dimensional cell culture was used to evaluate the effects on growth of tumor spheroids. Fluopsin C was cytotoxic (1) producing cell division arrest in the G1 phase, (2) elevating expression of mRNA of the CDKN1A gene and (3) decrease in expression of mRNA H2AFX gene. Further, fluopsin C enhanced DNA damage as evidenced by increased expression of mRNA of GADD45A and GPX1 genes, indicating that reactive oxygen species (ROS) may be involved in the observed genotoxic response. Reticulum stress was also detected as noted from activation of the ribonuclease inositol-requiring protein 1 (IRE1) pathway, since a rise in mRNA expression of the ERN1 and TRAF2 genes was observed. During the cell death process, an increase in mRNA expression of the BBC3 gene was noted, indicating participation of this antibiotic in oncotic (ischemic) cell death. Data thus demonstrated for the first time that fluopsin C interferes with the volume of tumor spheroids, in order to attenuate their growth. Our findings show that fluopsin C modulates essential molecular processes in response to stress and cell death.
Radio detection of high-energy cosmic rays with the Auger Engineering Radio Array (PISA 2015)
Creators: name: Schröder, Frank G.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The Auger Engineering Radio Array (AERA) is an enhancement of the Pierre Auger Observatory in Argentina. Covering about View the $17\,$km$^2$, AERA is the world-largest antenna array for cosmic-ray observation. It consists of more than 150 antenna stations detecting the radio signal emitted by air showers, i.e., cascades of secondary particles caused by primary cosmic rays hitting the atmosphere. At the beginning, technical goals had been in focus: first of all, the successful demonstration that a large-scale antenna array consisting of autonomous stations is feasible. Moreover, techniques for calibration of the antennas and time calibration of the array have been developed, as well as special software for the data analysis. Meanwhile physics goals come into focus. At the Pierre Auger Observatory air showers are simultaneously detected by several detector systems, in particular water-Cherenkov detectors at the surface, underground muon detectors, and fluorescence telescopes, which enables cross-calibration of different detection techniques. For the direction and energy of air showers, the precision achieved by AERA is already competitive; for the type of primary particle, several methods are tested and optimized. By combining AERA with the particle detectors we aim for a better understanding of cosmic rays in the energy range from approximately $0.3$ to $10\,$EeV, i.e., significantly higher energies than preceding radio arrays.
description: Proceedings of PISA 2015 (published in Nucl. Instr. Meth A)
Factores que inciden en la productividad del recurso humano en las empresas del sector alimenticio de la ciudad de Cartagena de Indias
Creators: name: Barrios Sierra, Nelson
name: Aguirre González, Wilder
Publisher: name: Universidad de Cartagena
Year: 2004
Subjects: Recursos humanos
Capital humano
Productividad laboral - Sector alimenticio - Cartagena (Bolívar)

description: Tesis (Administrador de Empresas) -- Universidad de Cartagena. Facultad de Ciencias Económicas. Programa de Administración de Empresas. 2004
description: El presente estudio tiene por objeto identificar los factores que inciden en la productividad del recurso humano en las empresas del sector alimenticio de la ciudad de Cartagena, mediante el análisis de su comportamiento, que permita al sector empresarial de la ciudad de Cartagena modelar estrategias orientadas a la optimización de la productividad laboral.
Vacuum polarization in asymptotically Lifshitz black holes
Creators: name: Quinta, Gonçalo M.
name: Flachi, Antonino
name: Lemos, José P. S.
Publisher: name: arXiv
Year: 2016
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: There has been considerable interest in applying the gauge/gravity duality to condensed matter theories with particular attention being devoted to gravity duals (Lifshitz spacetimes) of theories that exhibit anisotropic scaling. In this context, black hole solutions with Lifshitz asymptotics have also been constructed aiming at incorporating finite temperature effects. The goal here is to look at quantum polarization effects in these spacetimes, and to this aim, we develop a way to compute the coincidence limit of the Green's function for massive, non-minimally coupled scalar fields, adapting to the present situation the analysis developed for the case of asymptotically anti de Sitter black holes. The basics are similar to previous calculations, however in the Lifshitz case one needs to extend previous results to include a more general form for the metric and dependence on the dynamical exponent. All formulae are shown to reduce to the AdS case studied before once the value of the dynamical exponent is set to unity and the metric functions are accordingly chosen. The analytical results we present are general and can be applied to a variety of cases, in fact, to all spherically symmetric Lifshitz black hole solutions. We also implement the numerical analysis choosing some known Lifshitz black hole solutions as illustration.
Manifestation of nonlocal electron-electron interaction in graphene
Creators: name: Ulstrup, Søren
name: Schüler, Malte
name: Bianchi, Marco
name: Fromm, Felix
name: Raidel, Christian
name: Seyller, Thomas
name: Wehling, Tim
name: Hofmann, Philip
Publisher: name: arXiv
Year: 2016
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Graphene is an ideal platform to study many-body effects due to its semimetallic character and the possibility to dope it over a wide range. Here we study the width of graphene's occupied $π$-band as a function of doping using angle-resolved photoemission. Upon increasing electron doping, we observe the expected shift of the band to higher binding energies. However, this shift is not rigid and the bottom of the band moves less than the Dirac point. We show that the observed shift cannot be accounted for by band structure calculations in the local density approximation but that non-local exchange interactions must be taken into account.
description: 5 pages, 3 figures
Award_2022_10
Creators: name: Pallottino Federico
name: Figorilli, Simone
name: Antonucci Francesca
name: Costa Corrado
Publisher: name: OSF
Year: 2024

description: October 2022 – Editor’s Choice Article for the publication: Fanigliulo R, Antonucci F, Figorilli S, Pochi D, Pallottino F, Fornaciari L, Grilli R, Costa C, 2020. Light drone-based application to assess soil tilvandeplage quality parameters. SENSORS, 20: 728. https://doi.org/10.3390/s20030728 MDPI, Ottobre 2022.
COVID-19 antivaxxers are distinct from the vaccine hesitant in the United States: Results from a Population-based Survey and latent class analysis
Creators: name: Huang, Kai
Publisher: name: University of Chicago
Year: 2022
Subjects: subject: COVID-19
subject: Vaccine hesitancy
subject: Latent Class Analysis
subject: Attribute intersectionality

description: Antivaxxers and the vaccine hesitant express different degrees of resistance to COVID-19 vaccination yet are often considered as a monolith. Little is understood about the attributes of these two sub-populations and combining them conceptually makes public health vaccine surveillance less specific and has implications for intervention implementation and scale-up, including for future vaccine preventable epidemics in the United States. The purpose of this quantitative study is to provide detailed information about how the attribute intersectionality of vaccine hesitancy categorized vaccine hesitant and antivaxx in the United States during the COVID-19 pandemic. By analyzing the data of the AmeriSpeak custom survey conducted in summer 2021, this study selected 1184 eligible participants who expressed certain degrees of COVID vaccination hesitancy, and proceeded with latent class analysis (LCA). This research shows that based on the attribute intersectionality of vaccine hesitancy, both vaccine hesitant and antivaxx groups can be divided into three latent classes which are Multi-issue dominant, Side-effect dominant, and Non-dominant. Moreover, while the two groups can be distinguished by demographic characteristics, medical attitudes, COVID-related behaviors, and health outcome characteristics, the descriptors of latent class membership further reflected their categorical characteristics from a group-wise perspective. Further, the latent classes showed distinct performances across various indicators from a pair-wise perspective. These findings could shed light on developing tailored public health policy for social groups with different mindsets on mass vaccination.
On a coefficient in trace formulas for Wiener-Hopf operators
Creators: name: Sobolev, A. V.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Spectral Theory (math.SP)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: Primary 47B35, Secondary 47B1

description: Let $a = a(ξ), ξ\in\mathbb R,$ be a smooth function quickly decreasing at infinity. For the Wiener-Hopf operator $W(a)$ with the symbol $a$, and a smooth function $g:\mathbb C\to~\mathbb C$, H. Widom in 1982 established the following trace formula: \[ {\rm tr}\bigl(g\bigl(W(a)\bigr) - W(g\circ a)\bigr) = \mathcal B(a; g), \] where $\mathcal B(a; g)$ is given explicitly in terms of the functions $a$ and $g$. The paper analyses the coefficient $\mathcal B(a; g)$ for a class of non-smooth functions $g$ assuming that $a$ is real-valued. A representative example of one such function is $g(t) = |t|^γ$ with some $γ\in (0, 1]$.
description: 21 pages
New screening method for common heart disorder
Creators: name: Research, Nature
Publisher: name: Manara - Qatar Research Repository
Year: 2023
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3201
subject: Cardiovascular medicine and haematology

description: A team of Egyptian cardiologists has discovered a simple new way of diagnosing the world’s most common genetically transmitted heart disorder and identifying affected patients who have an increased risk of adverse cardiovascular events . Hypertrophic cardiomyopathy (HCM) affects approximately 1 in 500 people and is characterised primarily by abnormal thickening of the heart’s muscle tissue, which makes it harder for the heart to pump blood around the body. One common complication of the condition is obstruction of the left ventricular outflow tract (LVOT), in which the volume of blood pumped around the body is dramatically reduced. LVOT obstruction can occur under stress and during exercise, when contractility of the left ventricle increases. It leads to progression of hypertrophic cardiomyopathy, and predicts adverse outcomes such as cardiac arrest and sudden death in HCM patients. Over 30 percent of patients who have non-obstructive cardiomyopathy do end up with obstruction under stress or exercise. Clinicians can provoke LVOT obstruction in patients by exercise treadmill testing, in order to screen for and diagnose HCM, and to predict future complications, but this is not possible in those who are not able to do exercise for any reason. Hala Mahfouz Badran of Menoufiya University and her colleagues studied 39 HCM patients. They used echocardiography to measure the patients’ heart activity at rest, then compared exercise and an under-the-tongue spray of isosorbide dinitrate (ISDN) — which is used to treat angina — in their ability to induce and evaluate LVOT obstruction. They found that ISDN inhalation provokes LVOT obstruction as effectively as exercise testing, as indicated by measurements of changes in the pressure produced by blood as it is pumped out of the left ventricle. ISDN inhalation is therefore equivalent to exercise testing for detecting LVOT obstruction, and can be reliably used in a clinical setting to identify symptomatic HCM patients who cannot perform the exercise test.Other InformationPublished in: QScience.com Highlights, Published by Nature Research for Hamad bin Khalifa University Press (HBKU Press)
License: http://creativecommons.org/licenses/by/4.0
Estudio de optimización de la planta de tratamiento de agua potable del municipio de San Jacinto, Bolívar
Creators: name: Mercado Perez, Jose Luis
name: Ruiz Torres, Liliana Maria
Publisher: name: Universidad de Cartagena
Year: 2003
Subjects: Tratamiento de agua potable

description: Tesis (Ingeniero Civil). - - Universidad de Cartagena. Facultad de Ciencias e Ingeniería. Programa de Ingeniería Civil. 2003.
description: El presente estudio tiene por objeto realizar el diseño optimo de la planta de tratamiento de agua potable del municipio de San Jacinto Bolivar.
Funktionale Zusammenhänge auf den Punkt gebracht. Oder: Warum sich Funktionen nicht gerne „verschieben“ lassen
Creators: name: Marxer, Michael
Publisher: name: Gesellschaft für Didaktik der Mathematik
Year: 2015
Subjects: subject: 510

description: Beim Thema „Funktionen“ fokussiert der Mathematikunterricht häufig auf die Betrachtung von Graphen und deren Charakteristika unter Verwendung algebraischer Werkzeuge. Schülerformulierungen wie „Ich verschiebe die Funktion“ lassen erkennen, dass ein problematisches Verständnis von Funktionen im Sinne graphischer Objekte vorliegt. Der Beitrag stellt Überlegungen an, wie die Formalisierung der Abhängigkeit von Größen stärker ins Blickfeld gerückt werden kann und illustriert dies an Aufgabenformaten
Clima organizacional con relación a la motivación y la calidad de vida laboral en los empleados de la E.S.E. Hospital Local de Arjona
Creators: name: Castilla Ramos, Karol Luis
name: Padilla Viloria, John Jairo
Publisher: name: Universidad de Cartagena
Year: 2011
Subjects: Clima organizacional - E.S.E. Hospital Local Arjona - Bolívar
Motivación del empleado
Administración de personal

description: Tesis (Administrador de Empresas).--Universidad de Cartagena. Facultad de Ciencias Económicas. Programa de Administración de Empresas, 2011
description: El objetivo de este trabajo busca analizar las condiciones de la calidad de vida laboral y motivacional en la E.S.E. Hospital local Arjona con relación al clima organizacional de sus miembros, para lograr un buen desempeño individual y colectivo alcanzando los objetivos personales y organizacionales.
Mathematische Exkursion – ein Beispiel für forschendes Lernen in der Ingenieurmathematik
Creators: name: Michaelsen, Silke
name: Link, Frauke
Publisher: name: Gesellschaft für Didaktik der Mathematik
Year: 2015
Subjects: subject: 510

description: Forschendes Lernen in der Ingenieurmathematik anzusiedeln erweist sich aus verschiedenen Gründen als schwierig: Die Motivation zur Beschäftigung mit der Sache an sich muss für den Prozess forschenden Lernens vorhanden sein (vgl. BAK 1970). Mathematik ist allerdings für Studierende der Ingenieurwissenschaften Mittel zum Zweck des anzustrebenden Berufsziels und das Interesse bezieht sich daher in der Regel eher auf die Bearbeitung von Anwendungsproblemen als auf die Auseinandersetzung mit der fachinhaltlichen Struktur, die auch Begriffsgenese, Herleitungen und Beweise einschließt. Als Lösung wird vielfach vorgeschlagen, insbesondere für diese Gruppe praktische Anwendungsprobleme zu entwickeln bzw. zu präsentieren (vgl. BAK 1970, Rooch et al. 2013). Im Kontext forschenden Lernens konkurriert dies jedoch mit der Erwartung, dass die Studierenden dezidiert allein die Entscheidung für ein interessantes Thema treffen in Kombination mit der Erwartung, dass sie nicht allein auf der Anwendungsebene bleiben, sondern auch mathematisch interessante Phänomene entdecken. Konkret stand also die Erwartung im Raum, dass Studierende der Ingenieurwissenschaften sich im Rahmen forschenden Lernens in Mathematik mit Mathematik und ihren Strukturen auseinandersetzen sollten.
Campodea (Campodea) apennina Ramellini 1998
Creators: name: Sendra, Alberto
name: Reboleira, Ana Sofia P. S.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplura
Campodeidae
Campodea
Campodea apennina

description: Campodea (Campodea) apennina Ramellini, 1998
Campodea (Campodea?) apennina Ramellini, 1998: 21, figs 1–11.
Diagnosis (Ramellini 1998)
Body length 3.0– 3.8 mm; epicuticle with microdenticles; short smooth or with a few thin apical barbs clothing setae; antennae with 22–25 antennomeres; sensillum of third antennomere in dorsal position; 1+1 ma, 1+1 lp macrosetae on mesonotum, 1+1 ma on metanotum; short (ma, la) and long (lp) barbed notal macrosetae; thin pine cone shape marginal setae; one trochanteral sensillum; 1+1 lp macrosetae on VII urotergite, 3+3 lp on VIII urotergite and 5+5 lp on IX abdominal segment.
Habitat and distribution
Soil-dwelling species collected in two localities in Abruzzo National Park, Lazio, Italy (Ramellini 1998).
description: Published as part of Sendra, Alberto & Reboleira, Ana Sofia P. S., 2020, Euro-Mediterranean fauna of Campodeinae (Campodeidae, Diplura), pp. 1-130 in European Journal of Taxonomy 728 on page 28, DOI: 10.5852/ejt.2020.728.1181, http://zenodo.org/record/4316883
Correlation functions of the integrable spin-s chain
Creators: name: Ribeiro, G. A. P.
name: Klümper, A.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Mathematical Physics (math-ph)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences

description: We study the correlation functions of su(2) invariant spin-s chains in the thermodynamic limit. We derive non-linear integral equations for an auxiliary correlation function $ω$ for any spin s and finite temperature T. For the spin-3/2 chain for arbitrary temperature and zero magnetic field we obtain algebraic expressions for the reduced density matrix of two-sites. In the zero temperature limit, the density matrix elements are evaluated analytically and appear to be given in terms of Riemann's zeta function values of even and odd arguments.
description: 35 pages, 1 figure
Stellenwerte verstehen- Empirische Einblicke in die Förderung des dekadischen Verständnisses bei Grundschulkindern
Creators: name: Mosandl, Corinna
Publisher: name: Gesellschaft für Didaktik der Mathematik
Year: 2015
Subjects: subject: 510

description: Ein Verständnis der Stellenwerte gilt als Grundlage für vielfältige mathematische Aktivitäten und Kenntnisse. Es dient nicht nur dem allgemeinen Zahlverständnis (vgl. Krauthausen & Scherer 2011), sondern auch dem Operationsverständnis (vgl. Carpenter et al. 1997) und kann damit aus Voraussetzung für ein flexibles und verständiges Rechnen gesehen werden (vgl. van de Walle 1994, Moser Opitz 2007). Daneben spielt eine sichere Kenntnis über die Eigenschaften unseres gebräuchlichen Zehner- Stellenwertsystems eine wichtige Rolle beim Umgang mit dekadischen Maßeinheiten (vgl. Häsel-Weide & Nührenbörger 2012) sowie beim Schätzen und Überschlagen von Mengen (vgl. Scherer 2009). Eine besondere Bedeutung bekommt ein sicheres Basiswissen im Bereich der Stellenwerte der natürlichen Zahlen, wenn im Unterricht der Sekundarstufe 1 die Erweiterung des Zahlbereichs zu den Dezimalzahlen thematisiert wird (vgl. Heckmann 2007).
Employment-related Social Citizenship and Its Resource-based Underpinnings: An Assessment of Country-year Data
Creators: name: Burgoon, Brian
Publisher: name: Zenodo
Year: 2022
Subjects: Welfare state
European Union
social rights
Social Europe
social policies
employment policies
unemployment
economic insecurity
policy implementation
take-up rates

description: This Working Paper explores social-rights realization in the realm of employment, empirically applying the resource-based framework of the EUSOCIALCIT research consortium. It does so by analyzing quantitative, aggregate country-year information about national-level employment-related social rights resources, outputs and outcomes for EU member states and other industrialized democracies between 1960 and 2018. Such analysis clarifies two fundamental aspects of social-rights realization. First, it systematically tracks developments in employment-related outcomes, outputs and macro-level proxies for resources – all germane to employment-related social rights at the national level. Do we see deepening social citizenship in Europe by these measures? The answer is, broadly, “yes”: the data reveal substantial deepening of many measures of Europe’s labour-related resources, outputs and outcomes since the 1970s. Second, the Working Paper explores the hypothesized causal chains linking resources to outputs and to outcomes in the realization of social rights. Using basic statistical regression techniques, the focus is on whether and how measures of social-rights resources are empirically associated with (subsequent) measures of outputs and outcomes. Do resources foster the realization of social rights in practice measured in outputs and outcomes? The answer again is ‘yes’. There is a lot of variation with respect to which macro-level resource patterns matter for which measures of outputs and outcomes – reflecting the imperfections of the measures, not just the differences in substantive implications of resources. However, country-years marked by more substantial normative, instrumental and enforcement resources tend to develop more substantial social-rights outputs and outcomes.
Neural Stream Functions
Creators: name: Wurster, Skylar Wolfgang
name: Guo, Hanqi
name: Peterka, Tom
name: Shen, Han-Wei
Publisher: name: arXiv
Year: 2023
Subjects: subject: Graphics (cs.GR)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: We present a neural network approach to compute stream functions, which are scalar functions with gradients orthogonal to a given vector field. As a result, isosurfaces of the stream function extract stream surfaces, which can be visualized to analyze flow features. Our approach takes a vector field as input and trains an implicit neural representation to learn a stream function for that vector field. The network learns to map input coordinates to a stream function value by minimizing the inner product of the gradient of the neural network's output and the vector field. Since stream function solutions may not be unique, we give optional constraints for the network to learn particular stream functions of interest. Specifically, we introduce regularizing loss functions that can optionally be used to generate stream function solutions whose stream surfaces follow the flow field's curvature, or that can learn a stream function that includes a stream surface passing through a seeding rake. We also discuss considerations for properly visualizing the trained implicit network and extracting artifact-free surfaces. We compare our results with other implicit solutions and present qualitative and quantitative results for several synthetic and simulated vector fields.
description: Accepted and presented at PVIS2023 in Seoul, South Korea
Vergebung in einer unversöhnten Welt
Creators: name: Floristán Samanes, Casiano
name: Duquoc, Christian
Publisher: name: Concilium
Year: 1970

description: Concilium, Bd. 22 Nr. 2 (1986): Concilium: Internationale Zeitschrift für Theologie, Band 22, Heft 2
title: Zeitbezogene Quantitätsanalyse der in PubMed publizierten Artikel über randomisierte kontrollierte Studien inner- und außerhalb der Zahnmedizin
Creators: name: Jung, Marvin
name: Wissing, Michael  ‎
name: Motschall, Edith
name: Türp, Jens Christoph
Publisher: name: German Medical Science GMS Publishing House
Year: 2016
Subjects: subject: 610 Medical sciences; Medicine

description: Ziele: In der Qualitätshierarchie der externen Evidenz kommt innerhalb der therapeutischen Primärstudien randomisierten kontrollierten Studien (randomized controlled trials, RCTs) die höchste Evidenzstärke zu. Die in den medizinischen Fächern am häufigsten verwendete Meta-Datenbank[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Gemeinsam informiert entscheiden; 17. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
Generation of coherent radiation by magnetization reversal in graphene
Creators: name: Yukalov, V. I.
name: Henner, V. K.
name: Belozerova, T. S.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Local magnetic moments can be created in graphene by incorporating different defects. The possibility of regulating dynamics of magnetization in graphene, by employing the Purcell effect, is analyzed. The role of the system parameters in magnetization reversal is studied. The characteristics of such a reversal can be varied in a wide range, which can be used for various applications in spintronics. It is shown that fast magnetization reversal generates coherent radiation.
description: Latex file, 20 pages, 9 figures
Echoes of the hexagon: the icosikaitetragon (supplemental material)
Creators: name: Amore, Paolo
name: Carrizalez, Mauricio
name: Zarate, Ulises
Publisher: name: Zenodo
Year: 2023
Subjects: circle packing

description: We report all the curved hexagonal packing (CHP) configurations for N = 3k(k + 1) + 1 congruent disks in a regular icosikaitetragon (24 sides) and k = 2, . . . , 10.
title: Zulassungsstudien bei seltenen Erkrankungen: Eine retrospektive Analyse abgeschlossener Orphan Drug Bewertungen im Gemeinsamen Bundesausschuss
Creators: name: Schulz, Sandra
name: Passon, Anna
name: Kulig, Michael
name: Matthias, Katja
Publisher: name: German Medical Science GMS Publishing House
Year: 2016
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Der Gemeinsame Bundesausschuss (G-BA) führt für alle neu zugelassenen Arzneimittel eine (Zusatz)Nutzenbewertung durch (vgl. § 35a SGB V). Für Arzneimittel zur Behandlung seltener Erkrankungen (sogenannte Orphan Drugs) gelten einige Sonderregeln. So hat der Gesetzgeber[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Gemeinsam informiert entscheiden; 17. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
title: Zum Verhältnis externer und interner Evidenz am Beispiel der komplexen Intervention „Rehabilitative Maßnahmen bei Pflegebedürftigen“
Creators: name: Lübke, Norbert
Publisher: name: German Medical Science GMS Publishing House
Year: 2016
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Vom Kompetenz-Centrum Geriatrie wurde ein Gutachten zur Wirksamkeit rehabilitativer Maßnahmen bei älteren Pflegebedürftigen im Hinblick auf den nutzbaren Erkenntnisgewinn für die Feststellung von Rehabilitationsbedarf bei der Pflegebegutachtung erstellt. Methoden:[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Gemeinsam informiert entscheiden; 17. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
Combination of small size and carboxyl functionalisation causes cytotoxicity of short carbon nanotubes
Creators: name: Fröhlich, Eleonore
name: Meindl, Claudia
name: Höfler, Anita
name: Leitinger, Gerd
name: Roblegg, Eva
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Plant Biology

description: The use of carbon nanotubes (CNTs) could improve medical diagnosis and treatment provided they show no adverse effects in the organism. In this study, short CNTs with different diameters with and without carboxyl surface functionalisation were assessed. After physicochemical characterisation, cytotoxicity in phagocytic and non-phagocytic cells was determined. The role of oxidative stress was evaluated according to the intracellular glutathione levels and protection by N-acetyl cysteine (NAC). In addition to this, the mode of cell death was also investigated. CNTs <8 nm acted more cytotoxic than CNTs ≥20 nm and carboxylated CNTs more than pristine CNTs. Protection by NAC was maximal for large diameter pristine CNTs and minimal for small diameter carboxylated CNTs. Thin (<8 nm) CNTs acted mainly by disruption of membrane integrity and CNTs with larger diameter induced mainly apoptotic changes. It is concluded that cytotoxicity of small carboxylated CNTs occurs by necrosis and cannot be prevented by antioxidants.
Isoterma de absorción de Mango (Mangifera ínica) en polvo mediante modelos matemáticos y cálculo del claor isosterico por la ecuación de Claussyus Clapeyron
Creators: name: Escalante Acuña, José Alberto
name: Uricochea Del Castillo, Carlos Arturo
Publisher: name: Universidad de Cartagena
Year: 2017
Subjects: Tecnología de alimentos
Isoterma De Adsorción
Mango (mangifera índica)

description: Tesis (Ingeniero de Alimentos).--Universidad de Cartagena. Facultad de Ciencias E Ingenierías. Programa de Ingeniería de Alimentos, 2017
description: El objetivo de este trabajo fue determinar la isoterma de adsorción de mango en polvo a una temperatura de 37 °C, para un rango de Aw entre 0 y 0,9 aproximadamente.
The Grism Lens-Amplified Survey from Space (GLASS). VI. Comparing the Mass and Light in MACSJ0416.1-2403 using Frontier Field imaging and GLASS spectroscopy
Creators: name: Hoag, Austin
name: Huang, Kuang-Han
name: Treu, Tommaso
name: Bradač, Maruša
name: Schmidt, Kasper B.
name: Wang, Xin
name: Brammer, Gabriel B.
name: Broussard, Adam
name: Amorin, Ricardo
name: Castellano, Marco
name: Fontana, Adriano
name: Merlin, Emiliano
name: Schrabback, Tim
name: Trenti, Michele
name: Vulcani, Benedetta
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present a strong and weak gravitational lens model of the galaxy cluster MACSJ0416.1-2403, constrained using spectroscopy from the Grism Lens-Amplified Survey from Space (GLASS) and Hubble Frontier Fields (HFF) imaging data. We search for emission lines in known multiply imaged sources in the GLASS spectra, obtaining secure spectroscopic redshifts of 31 multiple images belonging to 16 distinct source galaxies. The GLASS spectra provide the first spectroscopic measurements for 6 of the source galaxies. The weak lensing signal is acquired from 884 galaxies in the F606W HFF image. By combining the weak lensing constraints with 15 multiple image systems with spectroscopic redshifts and 9 multiple image systems with photometric redshifts, we reconstruct the gravitational potential of the cluster on an adaptive grid. The resulting total mass density map is compared with a stellar mass density map obtained from the deep Spitzer Frontier Fields imaging data to study the relative distribution of stellar and total mass in the cluster. We find that the projected stellar mass to total mass ratio, $f_{\star}$, varies considerably with the stellar surface mass density. The mean projected stellar mass to total mass ratio is $\langle f_{\star} \rangle= 0.009 \pm 0.003 $ (stat.), but with a systematic error as large as $0.004-0.005$, dominated by the choice of the IMF. We find agreement with several recent measurements of $f_{\star}$ in massive cluster environments. The lensing maps of convergence, shear, and magnification are made available to the broader community in the standard HFF format.
description: 48 pages, 45 figures
Ag nanoparticles: size- and surface-dependent effects on model aquatic organisms and uptake evaluation with NanoSIMS
Creators: name: Georgantzopoulou, Anastasia
name: Balachandran, Yekkuni L.
name: Rosenkranz, Philipp
name: Dusinska, Maria
name: Lankoff, Anna
name: Wojewodzka, Maria
name: Kruszewski, Marcin
name: Guignard, Cédric
name: Audinot, Jean-Nicolas
name: Girija, Shanmugam
name: Hoffmann, Lucien
name: Gutleb, Arno C.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: This study aims to assess the effects of Ag particles synthesised by a chemical (Ag 20, 200 nm) and biological method (Ag 23, 27 nm) in aquatic organisms: the bacterium Vibrio fischeri, the alga Desmodesmus subspicatus and the crustacean Daphnia magna. Ag particles exerted toxic effects in all organisms studied with Ag particles 23 nm being the most potent. Although soluble Ag was released in all media, the differences between the tested Ag particles still cannot be explained solely based on soluble Ag. NanoSIMS analysis performed with D. magna showed that apart from their localisation in the gut lumen, Ag 200 nm and Ag NPs 23 nm seemed to pass through the epithelial barrier as well. Ag NPs 23 nm localised in specific areas seemed to be within the ovaries. This study strengthens the argument that size, method of synthesis as well as surface chemistry may affect the uptake and toxic effects of Ag NPs.
Evolution of Neptune at Near-Infrared Wavelengths from 1994 through 2022
Creators: name: Chavez, Erandi
name: de Pater, Imke
name: Redwing, Erin
name: Molter, Edward M.
name: Roman, Michael T.
name: Zorzi, Andrea
name: Alvarez, Carlos
name: Campbell, Randy
name: de Kleer, Katherine
name: Hueso, Ricardo
name: Wong, Michael H.
name: Lynam, Elinor Gates Paul David
name: Davies, Ashley G.
name: Aycock, Joel
name: Mcilroy, Jason
name: Pelletier, John
name: Ridenour, Anthony
name: Stickel, Terry
Publisher: name: arXiv
Year: 2023
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Using archival near-infrared observations from the Keck and Lick Observatories and the Hubble Space Telescope, we document the evolution of Neptune's cloud activity from 1994 to 2022. We calculate the fraction of Neptune's disk that contained clouds, as well as the average brightness of both cloud features and cloud-free background over the planet's disk. We observe cloud activity and brightness maxima during 2002 and 2015, and minima during 2007 and 2020, the latter of which is particularly deep. Neptune's lack of cloud activity in 2020 is characterized by a near-total loss of clouds at mid-latitudes and continued activity at the South Pole. We find that the periodic variations in Neptune's disk-averaged brightness in the near-infrared H (1.6 $μ$m), K (2.1 $μ$m), FWCH4P15 (893 nm), F953N (955 nm), FWCH4P15 (965 nm), and F845M (845 nm) bands are dominated by discrete cloud activity, rather than changes in the background haze. The clear positive correlation we find between cloud activity and Solar Lyman-Alpha (121.56 nm) irradiance lends support to the theory that the periodicity in Neptune's cloud activity results from photochemical cloud/haze production triggered by Solar ultraviolet emissions.
description: 46 pages, 13 figures, accepted to Icarus
Ffunt@OWL: Qualifizierung fachfremd Mathematik unterrichtender Lehrerinnen und Lehrer im Regierungsbezirk Detmold (NRW)
Creators: name: Lünne, Steffen
name: Biehler, Rolf
Publisher: name: Gesellschaft für Didaktik der Mathematik
Year: 2015
Subjects: subject: 510

description: In Nordrhein-Westfalen liegt der Anteil der fachfremd Mathematik unterrichtenden Lehrerinnen und Lehrer in der Sekundarstufe I bei etwa 13,1% (Richter, Kuhl, Haag & Pant, 2013). In den kommenden Jahren wird ein so großer Teil der Mathematiklehrpersonen in den Ruhestand gehen, dass der Bedarf der Schulen nicht vom Nachwuchs gedeckt werden kann (Klemm, 2015), das verschärft die Problemlage. Vor diesem Hintergrund bieten die Bezirksregierungen Zertifikatskurse an, die fachfremd Mathematik unterrichtende Lehrpersonen qualifizieren. Im Beitrag wird ein solcher Zertifikatskurs vorgestellt, den das DZLM (www.dzlm.de) am Standort Paderborn neu entwickelt und gemeinsam mit der Bezirksregierung Detmold im Schuljahr 2014/15 durchführt. Im Fokus stehen dabei fachmathematische und fachdidaktische Kompetenzen, die gelebte Praxis an den Schulen und die Förderung wünschenswerter affektiv-motivationaler Charakteristika.
Rechenkniffe und Monsterterme in der Mathematik für Ingenieure
Creators: name: Mei, Robert Ivo
Publisher: name: Gesellschaft für Didaktik der Mathematik
Year: 2015
Subjects: subject: 510

description: Vergleicht man universitäre Mathematik-Aufgaben aus Anfangsvorlesungen in reinen Mathematikstudiengängen mit solchen in Ingenieurstudiengängen, so fällt auf, dass bei letzteren oft längere Terme verwendet werden und häufiger spezielle Kniffe zur Lösung nötig sind. Dieser Beitrag beschäftigt sich mit Gründen für dieses Phänomen, didaktischen Problemen, die sich daraus ergeben können, und möglichen Konsequenzen zum Umgang damit in der Lehre.
A Spectral Series Approach to High-Dimensional Nonparametric Regression
Creators: name: Lee, Ann B.
name: Izbicki, Rafael
Publisher: name: arXiv
Year: 2016
Subjects: subject: Methodology (stat.ME)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: A key question in modern statistics is how to make fast and reliable inferences for complex, high-dimensional data. While there has been much interest in sparse techniques, current methods do not generalize well to data with nonlinear structure. In this work, we present an orthogonal series estimator for predictors that are complex aggregate objects, such as natural images, galaxy spectra, trajectories, and movies. Our series approach ties together ideas from kernel machine learning, and Fourier methods. We expand the unknown regression on the data in terms of the eigenfunctions of a kernel-based operator, and we take advantage of orthogonality of the basis with respect to the underlying data distribution, P, to speed up computations and tuning of parameters. If the kernel is appropriately chosen, then the eigenfunctions adapt to the intrinsic geometry and dimension of the data. We provide theoretical guarantees for a radial kernel with varying bandwidth, and we relate smoothness of the regression function with respect to P to sparsity in the eigenbasis. Finally, using simulated and real-world data, we systematically compare the performance of the spectral series approach with classical kernel smoothing, k-nearest neighbors regression, kernel ridge regression, and state-of-the-art manifold and local regression methods.
The future of prostacyclin
Creators: name: Research, Nature
Publisher: name: Manara - Qatar Research Repository
Year: 2023
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3201
subject: Cardiovascular medicine and haematology

description: The discovery of prostaglandin in 1976 revolutionized the treatment of a rare cardiovascular condition called pulmonary arterial hypertension. However, current treatments are plagued by many unwanted side effects, and so its full therapeutic potential has not yet been realised. In a new review, Jane Mitchell of the National Heart and Lung Institute in London and her colleagues summarise what is known about prostacyclin synthesis and function, how this knowledge is being applied to produce treatments, and speculate on how nanomedicine and stem-cell-based treatments of the near future might overcome the limitations of current therapies . Prostacyclin is a powerful hormone that is released by endothelial cells lining the blood vessels. It protects the vessels by relaxing them and inhibiting the formation of blood clots. The hormone is synthesized from arachidonic acid within the endothelial cells by a series of chemical reactions catalysed by the concerted actions of the enzymes cyclo-oxygenase and prostacyclin synthase. Once formed, prostacyclin is actively exported out of endothelial cells by transporter proteins embedded in the membrane. It then exerts its powerful effects by binding to specialized cell-surface and nuclear receptors. Since the late 1990s, prostacyclin-based therapies have been used to treat pulmonary arterial hypertension, a rare cardiovascular condition characterised by prostacyclin imbalance, blood vessel constriction and blood clot formation. Pulmonary arterial hypertension is fatal, with sufferers dying less than two years after diagnosis if left untreated. Prostacyclin therapies have improved patient outcomes, extending life expectancy by 5–7 years. Many clinicians regard it as the most effective treatment available for the disease. But there’s a downside; all current therapies that use prostacyclin are associated with serious side effects, especially reduced blood pressure, along with flushing, jaw pain and nausea. What’s more, many of these therapies have to be administered in small doses delivered by continuous infusion, which can lead to sepsis or blood poisoning. Future therapies could overcome these limitations. Nanotechnology could soon be used to develop slow-release drug delivery systems that target specific blood vessels, which would likely make the therapy more effective while avoiding sepsis and may make the disease less fatal than it is. Using stem-cell technology, researchers may one day be able to replace the endothelial cells damaged in the condition.
Other InformationPublished in: QScience.com Highlights, Published by Nature Research for Hamad bin Khalifa University Press (HBKU Press)
License: http://creativecommons.org/licenses/by/4.0
Nonlinear heat conduction equations with memory: physical meaning and analytical results
Creators: name: Harris, Pietro Artale
name: Garra, Roberto
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We study nonlinear heat conduction equations with memory effects within the framework of the fractional calculus approach to the generalized Maxwell-Cattaneo law. Our main aim is to derive the governing equations of heat propagation, considering both the empirical temperature-dependence of the thermal conductivity coefficient (which introduces nonlinearity) and memory effects, according to the general theory of Gurtin and Pipkin of finite velocity thermal propagation with memory. In this framework, we consider in detail two different approaches to the generalized Maxwell-Cattaneo law, based on the application of long-tail Mittag-Leffler memory function and power law relaxation functions, leading to nonlinear time-fractional telegraph and wave-type equations. We also discuss some explicit analytical results to the model equations based on the generalized separating variable method and discuss their meaning in relation to some well-known results of the ordinary case.
The impact of UVB exposure and differentiation state of primary keratinocytes on their interaction with quantum dots
Creators: name: Mortensen, Luke J.
name: Ravichandran, Supriya
name: DeLouise, Lisa A.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: In this study we utilised an in vitro model system to gain insight into the potential cellular interactions that quantum dot (QD) nanoparticles may experience while transiting the viable skin epidermis, and we consider the effects of UVB exposure. UVB skin exposure is known to induce a skin barrier defect that facilitates QD stratum corneum penetration. Primary human keratinocytes were cultured in low and high calcium to induce basal and differentiated phenotypes, respectively. Results suggest that differentiation state plays a role in keratinocyte response to UVB exposure and exposure to negatively charged CdSe/ZnS core/shell QD. QD cell uptake increased with QD dose but association with differentiated cells was significantly lower than the basal keratinocyte phenotype. Differentiated keratinocytes were also less sensitive to the cytotoxic effects of UVB exposure. We did not observe an effect of UVB preexposure on QD cytotoxicity level despite the fact that fluorescent microscopy and flow cytometry data suggest that UVB may slightly increase QD uptake in the basal cell phenotype. The implications of these findings for assessing potential risk of human skin exposure are discussed.
Generation of toxic degradation products by sonication of Pluronic® dispersants: implications for nanotoxicity testing
Creators: name: Wang, Ruhung
name: Hughes, Tyler
name: Beck, Simon
name: Vakil, Samee
name: Li, Synyoung
name: Pantano, Paul
name: Draper, Rockford K.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry

description: Poloxamers (known by the trade name Pluronic®) are triblock copolymer surfactants that contain two polyethylene glycol blocks and one polypropylene glycol block of various sizes. Poloxamers are widely used as nanoparticle dispersants for nanotoxicity studies wherein nanoparticles are sonicated with a dispersant to prepare suspensions. It is known that poloxamers can be degraded during sonication and that reactive oxygen species contribute to the degradation process. However, the possibility that poloxamer degradation products are toxic to mammalian cells has not been well studied. We report here that aqueous solutions of poloxamer 188 (Pluronic® F-68) and poloxamer 407 (Pluronic® F-127) sonicated in the presence or absence of multi-walled carbon nanotubes (MWNTs) can became highly toxic to cultured cells. Moreover, toxicity correlated with the sonolytic degradation of the polymers. These findings suggest that caution should be used in interpreting the results of nanotoxicity studies where the potential sonolytic degradation of dispersants was not controlled.