cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sleep-Disordered Breathing Is Associated with Metabolic Syndrome in Outpatients with Diabetes Mellitus Type 2
Creators: name: Neumann, K.
name: Arzt, M.
name: Heid, I.
name: Böger, C.
name: Stadler, S.
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: ;
subject: 610 Medizin

description: Background. Metabolic syndrome (MS) and sleep-disordered breathing (SDB) are highly prevalent in patients with diabetes mellitus type 2 (DM2). The present study examined whether there is an independent association between SDB and MS in a sample of outpatients with DM2. Methods. MS was determined in 679 patients of the DIACORE-SDB substudy, a study of outpatients with DM2. According to the National Cholesterol Education Program (NCEP) criteria, MS is defined by at least three of the following five criteria: waist circumference of >102cm (men)/>88cm (women), blood pressure of 130/85mmHg, a fasting triglyceride level of >150mg/dl, high-density lipoprotein (HDL) of <40mg/dl (men)/<50mg/dl (women), and a fasting glucose level of 110mg/dl. The apnea-hypopnea index (AHI) was assessed with a 2-channel ambulatory monitoring device and used to define the severity of SDB (AHI<15.0: no/mild SDB; AHI 15.0-29.9: moderate SDB; AHI30.0: severe SDB). Results. 228 (34%) of the 679 participants (mean age 66 years, mean body mass index (BMI) 31.2kg/m(2), and mean AHI 14/hour) had SDB. MS was significantly more frequent in patients with more severe SDB (no/mild SDB vs. moderate SDB vs. severe SDB: 72% vs. 79% vs. 85%, respectively, p=0.038). Logistic regression analysis adjusted for sex, age, obesity (BMI30 kg/m(2)), and the HOMA index showed a significant association between the AHI and the presence of MS (OR =1.039 (1.011; 1.068); p=0.007). Further, male sex, obesity, and the HOMA index were significantly associated with MS. Conclusion. SDB is significantly and independently associated with MS in outpatients with DM2.
The Role of Chemokines in the Pathophysiology of Major Depressive Disorder
Creators: name: Milenkovic, Vladimir M.
name: Stanton, Evan H.
name: Nothdurfter, Caroline
name: Rupprecht, Rainer
name: Wetzel, Christian H.
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: major depressive disorder; chemokines; neuroinflammation
subject: 610 Medizin

description: Major depressive disorder (MDD) is a debilitating condition, whose high prevalence and multisymptomatic nature set its standing as a leading contributor to global disability. To better understand this psychiatric disease, various pathophysiological mechanisms have been proposed, including changes in monoaminergic neurotransmission, imbalance of excitatory and inhibitory signaling in the brain, hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis, and abnormalities in normal neurogenesis. While previous findings led to a deeper understanding of the disease, the pathogenesis of MDD has not yet been elucidated. Accumulating evidence has confirmed the association between chronic inflammation and MDD, which is manifested by increased levels of the C-reactive protein, as well as pro-inflammatory cytokines, such as Interleukin 1 beta, Interleukin 6, and the Tumor necrosis factor alpha. Furthermore, recent findings have implicated a related family of cytokines with chemotactic properties, known collectively as chemokines, in many neuroimmune processes relevant to psychiatric disorders. Chemokines are small (8–12 kDa) chemotactic cytokines, which are known to play roles in direct chemotaxis induction, leukocyte and macrophage migration, and inflammatory response propagation. The inflammatory chemokines possess the ability to induce migration of immune cells to the infection site, whereas their homeostatic chemokine counterparts are responsible for recruiting cells for their repair and maintenance. To further support the role of chemokines as central elements to healthy bodily function, recent studies suggest that these proteins demonstrate novel, brain-specific mechanisms including the modulation of neuroendocrine functions, chemotaxis, cell adhesion, and neuroinflammation. Elevated levels of chemokines in patient-derived serum have been detected in individuals diagnosed with major depressive disorder, bipolar disorder, and schizophrenia. Furthermore, despite the considerable heterogeneity of experimental samples and methodologies, existing biomarker studies have clearly demonstrated the important role of chemokines in the pathophysiology of psychiatric disorders. The purpose of this review is to summarize the data from contemporary experimental and clinical studies, and to evaluate available evidence for the role of chemokines in the central nervous system (CNS) under physiological and pathophysiological conditions. In light of recent results, chemokines could be considered as possible peripheral markers of psychiatric disorders, and/or targets for treating depressive disorders. View Full-Text
Myrmeleon bore
Creators: name: Badano, Davide
name: Pantaleoni, Roberto Antonio
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Neuroptera
Myrmeleontidae
Myrmeleon
Myrmeleon bore

description: Myrmeleon bore (Tjeder, 1941)
(Figs. 5D, 6D, 29)
The first observations of the larva of this antion predate the species description (Schenck 1877; Dewitz 1882) while the first actual description dates back to almost a century later (Friheden 1973). It was redescribed by Matsura (1987) and Nicoli Aldini (2007), who compared it with closely related species. This species is finally treated in some monographic volumes (Gepp & Hölzel 1989; Gepp 2010; Krivokhatsky 2011).
Examined specimens. Germany. Mecklenburg Vorpommern, Graal Müritz, VI.2011 (C. Kehlmaier), 3 L3.
Italy. Lombardy, Pieve Albignola (Pavia), Cascinotto Mensa, IX.1979 (R. Nicoli Aldini), 2 L3. Lombardy, Casterno (Milano), Ticino River, V.2012 (D. Piccolino), 1 L3.
Description of 3 rd instar larva. Size (based on 6 specimens): BL 8.31 mm; HL 2.06 mm (1.90–2.20), HW 1.74 mm (1.61–1.84), ML 2.25 mm (2.13–2.34), HW/HL 0.84, ML/HL 1.09. General colouring pale brown mottled with dark brown, ventrally very pale with dark brown spots; dorsal side of the head capsule with large markings on the clypeo-labrum and posterior V-shaped marking, lateral sides of the head with dark markings, ventral side of the head pale with a pair of median dark spots (Figs. 5D, 29c); mandibles pale brown with a dark apex; legs pale; setae of the body black. Head longer than wide; mandibles slightly longer than the head capsule (Fig. 29a); interdental mandibular setae: (~5)(2–3)(2–3)(1); ventral side of the mandible with few setae at the base; labial palpi 3-articulated (Figs. 5D, 29b). IX abdominal sternite with sparse ventral digging setae, followed by an anterior row of digging setae and two sessile rastra each bearing 4 bristles (Figs. 6D, 29d).
Bio-ecology. M. bore lives in fresh environments and it is absent from areas influenced by a Mediterranean climate. M. bore is associated with sandy biotopes such as coastal dunes, river banks and internal sand deposits. The pits are built in exposed conditions, although the first stages are often found in proximity of vegetation.
Distribution. Widespread in the Palaearctic, from western Europe eastward to Japan.
Remarks. The larva of M. bore is the only known European antlion with 3 palpomeres. This species is similar to M. inconspicuus and to the non sympatric M. mariaemathildae in overall morphology; it is differentiated by the larger dimensions and the relative proportions of the mandibles and the head capsule.
description: Published as part of Badano, Davide & Pantaleoni, Roberto Antonio, 2014, The larvae of European Myrmeleontidae (Neuroptera), pp. 1-71 in Zootaxa 3762 (1) on page 57, DOI: 10.11646/zootaxa.3762.1.1, http://zenodo.org/record/4909357
Phyllocoptes fabris Xue & Hong 2005
Creators: name: Xue, Xiao-Feng
name: Hong, Xiao-Yue
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Prostigmata
Eriophyidae
Phyllocoptes
Phyllocoptes fabris

description: Phyllocoptes fabris Xue & Hong, 2005. (Xue & Hong, 2005a)
Phyllocoptes fabris Xue & Hong, 2005: 15 –17.
Material examined
5 females and 5 males, from Abies fabri (Mast.) Craib. (Pinaceae), Longyuwan (33°42.53’N, 111°45.62’E), Luanchuan County, Henan Province, P. R. China, 19 July 2004, coll. X.­F. Xue.
Relation to host
Vagrant on leaf surface. No damage to the host was observed.
Distribution
China (Henan).
description: Published as part of Xue, Xiao-Feng & Hong, Xiao-Yue, 2006, Eriophyoid mite fauna from Henan Province, central China (Acari: Eriophyoidea) with descriptions of five new species, pp. 1-30 in Zootaxa 1204 on pages 14-15, DOI: 10.5281/zenodo.172352
Eothenomys olitor Thomas 1911
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Eothenomys
Eothenomys olitor

description: Eothenomys olitor Thomas 1911
Eothenomys olitor Thomas 1911, Abstr. Proc. Zool. Soc. Lond., 1911 (100): 50.
Type Locality: China, Yunnan, Chao-tung-fu (= Zhaotong Xian), 6700 ft [2042 m] (Kaneko, 1999 b, provided additional information).
Vernacular Names: Black-eared Red-backed Vole.
Synonyms: Eothenomys hypolitor Wang and Li 2000.
Distribution: NE Yunnan at the type locality and SW Yunnan between the Mekong and Salween River valleys, 1800-3350 m (Kaneko, 1996 b).
Conservation: IUCN – Lower Risk (lc).
Discussion: E. chinensis species group. The smallest Eothenomys in body size. Hinton (1926 a) allocated olitor to the subgenus Eothenomys, as did Corbet and Hill (1992), but others have placed it in Anteliomys (G. M. Allen, 1940; Gromov and Polyakov, 1977) or in the subgenus Caryomys (Pavlinov et al., 1995 a). G. M. Allen (1940) extended the range to W Yunnan, but Kaneko (1996 b) explained why this record is not olitor; inclusion of hypolitor observes the summary of Ye et al. (2002).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 982, DOI: 10.5281/zenodo.7316535
Latin Papyri from Herculaneum: list, description and transcription
Creators: name: Marichal, Robert
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015

description: vue 36
description: "Description and transcription of Latin papyri from Herculaneum; in most cases all the material concerning a single papyrus is collected in one folder often containing the pictures of the papyrus itself; sometimes one folder focuses on 2 papyri; the word 'recopiés' is on the cover page of the folder. "
description: Source: 4MAR_8_2_5-12
description: created: n.d.
Cells under pressure – the relationship between hydrostatic pressure and mesenchymal stem cell chondrogenesis
Creators: name: Pattappa, Girish
name: Zellner, J.
name: Johnstone, B.
name: Docheva, Denitsa
name: Angele, Peter
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: INTERSTITIAL FLUID PRESSURIZATION; ESTROGEN REPLACEMENT THERAPY; IN-VITRO CHONDROGENESIS; SENSITIVE ION-CHANNEL; BONE-MARROW; ARTICULAR-CARTILAGE; PROGENITOR CELLS; REGULATES CHONDROGENESIS; MECHANICAL STIMULATION; FUNCTIONAL-DEVELOPMENT; Cartilage; mesenchymal stem cells; chondrogenesis; hydrostatic pressure; mechanobiology; early osteoarthritis
subject: 610 Medizin

description: Early osteoarthritis (OA), characterised by cartilage defects, is a degenerative disease that greatly affects the adult population. Cell-based tissue engineering methods are being explored as a solution for the treatment of these chondral defects. Chondrocytes are already in clinical use but other cell types with chondrogenic properties, such as mesenchymal stem cells (MSCs), are being researched. However, present methods for differentiating these cells into stable articular-cartilage chondrocytes that contribute to joint regeneration are not effective, despite extensive investigation. Environmental stimuli, such as mechanical forces, influence chondrogenic response and are beneficial with respect to matrix formation. In vivo, cartilage is subjected to multiaxial loading involving compressive, tensile, shear and fluid flow. The cellular response and tissue formation upon loading are being intensively studied in the cartilage tissue-engineering research field. The study of the effects of hydrostatic pressure on cartilage formation belongs to the large area of mechanobiology. During cartilage loading, interstitial fluid is pressurised and the surrounding matrix delays pressure loss by reducing fluid flow rate from pressurised regions. This fluid pressurisation is known as hydrostatic pressure, where a uniform stress around the cell occurs without cellular deformation. In vitro studies, examining chondrocytes under hydrostatic pressure, have described its anabolic effect and similar studies have evaluated the effect of hydrostatic pressure on MSC chondrogenesis. The present review summarises the results of these studies and discusses the mechanisms through which hydrostatic pressure exerts its effects.
Stenostomum gotlandense Larssson & Willems 2010
Creators: name: Diez, Yander L.
name: Schmidt-Rhaesa, Andreas
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Platyhelminthes
Catenulida
Stenostomidae
Stenostomum
Stenostomum gotlandense

description: Stenostomum gotlandense Larsson & Willems, 2010
Fig. 1
Known distribution.
Species only known, until now, from Gotland, Sweden (Larsson et al. 2008; Larsson and Willems 2010).
Material.
Two specimens studied alive and stored in absolute ethanol for molecular analyses, one of them sequenced; collected in Kirchwerder-Fünfhausen, submerged vegetation and litter in an irrigation channel, 0.1–0.2 m deep.
Remarks.
Specimens measuring 768–957 µm long (x ̄ = 863 µm; n = 2) and 90–110 µm at widest point (x ̄ = 100 µm; n = 2), with two zooids, slender, tapering to both rounded extremes (Fig. 1 A). The ciliated pits (Fig. 1 B: cp) are relative short and open close to the most anterior part of the body. The epidermis is fully ciliated. Larger cilia are distributed along the body, particularly in the anterior and posterior ends. The brain (Fig. 1 B: br) consists of two pairs of lobes, the anterior brain (Fig. 1 C: ab) and the posterior brain (Fig. 1 C: pb). We were not able to determine the exact number of compartments of the anterior brain, but in one specimen there appear to exist seven. Refractile bodies not present. Proximal rim of the pharynx (Fig. 1 A, B: ph) with a number of folds and surrounds the large mouth opening (Fig. 1 A, B: m). The protonephridium (Fig. 1 D: pn) ends in a nephridiopore at the posterior end of the body.
As noted by Larsson and Willems (2010), the folded rim of the pharynx, the large mouth opening, and the small ciliated pits represent a unique combination of morphological traits within Stenostomum. Our morphological identification is further corroborated by the phylogenetic analysis, leading us to confidently report this species for the first time in Germany, specifically in Hamburg. The German specimens are similar in size, considering the length of the first zooid (495–588 µm), to those from Sweden (500 µm). However, Larsson and Willems (2010) observed that their specimens exhibited approximately 10 compartments in the anterior brain, whereas the specimens from Hamburg present about seven. Nonetheless, one specimen illustrated by Larsson and Willems (2010: fig. 3 B) shows only six segments in the anterior brain.
description: Published as part of Diez, Yander L. & Schmidt-Rhaesa, Andreas, 2024, Little neighbours in Hamburg: free-living aquatic flatworms (Platyhelminthes), pp. 279-310 in Evolutionary Systematics 8 (2) on pages 279-310, DOI: 10.3897/evolsyst.8.139468
Topical Diclofenac Reprograms Metabolism and Immune Cell Infiltration in Actinic Keratosis
Creators: name: Singer, Katrin
name: Dettmer, Katja
name: Unger, Petra
name: Schönhammer, Gabriele
name: Renner, Kathrin
name: Peter, Katrin
name: Siska, Peter J.
name: Berneburg, Mark
name: Herr, Wolfgang
name: Oefner, Peter J.
name: Karrer, Sigrid
name: Kreutz, Marina
name: Datz, Elisabeth
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: LACTIC-ACID; DICLOFENAC/HYALURONIC ACID; LANGERHANS CELLS; DOWN-REGULATION; HUMAN TUMORS; RISK-FACTORS; EXPRESSION; GEL; CYCLOOXYGENASE-2; 2.5-PERCENT; actinic keratosis; diclofenac; CD8; CD1a; metabolism; lactate
subject: 610 Medizin

description: Background: Melanoma and squamous cell carcinoma of the skin are characterized by an altered glucose metabolism, but little is known about metabolic changes in precancerous skin lesions such as actinic keratosis (AK). Here, we studied the central carbon metabolism and immune cell infiltrate of actinic keratosis lesions before, under, and 4 weeks after treatment with topical diclofenac (Solaraze (R)). Methods: This study was designed as a prospective, randomized, controlled, monocentric investigation (ClinicalTrials.gov Identifier: NCT01935531). Myeloid and T cell infiltration was analyzed in skin biopsies from 28 patients by immunohistochemistry. Furthermore, immune cell activation was determined via quantitative real-time PCR (IFN-gamma, IL-10, CSF1 , TGF-beta, IL-6). Glucose, amino acid and Krebs' cycle metabolism was studied by mass spectrometry prior, during and after treatment with topical diclofenac. Biopsies from sun-exposed, untreated, healthy skin served as controls. Results: Increased lactate and decreased glucose levels suggested accelerated glycolysis in pre-treatment AK. Further, levels of Krebs' cycle intermediates other than citrate and amino acids were elevated. Analysis of the immune infiltrate revealed less epidermal CD1a+ cells but increased frequencies of dermal CD8+ T cells in AK. Treatment with diclofenac reduced lactate and amino acid levels in AK, especially in responding lesions, and induced an infiltration of dermal CD8+ T cells accompanied by high IFN-gamma mRNA expression, suggesting improved T cell function. Discussion: Our study clearly demonstrated that not only cancers but also pre-malignant skin lesions, like AK, exhibit profound changes in metabolism, correlating with an altered immune infiltrate. Diclofenac normalizes metabolism, immune cell infiltration and function in AK lesions, suggesting a novel mechanism of action.
title: Rapport de voyage, Annam (1899) : Ligne du Corps expéditionnaire d'Orient, 1916, voyage militarisé
Creators: name: Advinent, Monsieur
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Compagnie des Messageries Maritimes
subject: Transports maritimes - Histoire
subject: Marine marchande
subject: Journaux de bord

description: Chapitrage : Rapport du commandant
description: Source: French Lines & Compagnies, 1997 002 3939-69
description: Coverage: 1916-03-11/1916-04-17
Staudinger, Hugo / Behler, Wolfgang: Grundprobleme menschlichen Nachdenkens
Creators: name: Hammer, S.
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 27 (1986): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 27
D2.4 Validation of Temperature and Humidity in a Greenhouse Environment using CFD
Creators: name: Dudli, David
name: Banica, Marius
name: Danesi, Serena
Publisher: name: Zenodo
Year: 2024
Subjects: TheGreefa
H2020
modelling
CFD

description: This report is part of WP2 – Modelling and Control in TheGreefa project. It describes the development of the CFD model mentioned to predict the microclimate in a greenhouse. The previous scope of using this model to identify suitable sensor positions and locations for air conditioning units is no longer pursued. Instead, this study focuses on the modelling of radiation and humidity. In contrast to the previous report, these complex phenomena can also be validated with measurement data from an experimental greenhouse in Chorfech, Tunisia. Due to these new circumstances, some findings from the simulation for the Wädenswil greenhouse are no longer applicable.
Eothenomys proditor Hinton 1923
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Eothenomys
Eothenomys proditor

description: Eothenomys proditor Hinton 1923
Eothenomys proditor Hinton 1923, Ann. Mag. Nat. Hist., ser. 9, 11: 152.
Type Locality: China, Yunnan, Lichiang Range (=Yulongxuen), 13,000 ft (Kaneko, 1996 b, provided additional information).
Vernacular Names: Yulongxuen Red-backed Vole.
Distribution: "Restricted to the border between Sichuan and Yunnan, at around 27- 28°N and 100- 102°E, and that it lives in meadows and in rocky areas" (Kaneko, 1996 b:109); known altitudinal range 2500-4200 m.
Conservation: IUCN – Lower Risk (lc).
Discussion: E. chinensis species group. Morphologically a giant version of E. olitor (Kaneko, 1996 b). Treated as a species of Eothenomys (G. M. Allen, 1940; Corbet and Hill, 1992; Hinton, 1926 a), but placed in Anteliomys (Gromov and Polyakov, 1977), and in subgenus Caryomys (Pavlinov et al., 1995 a). In his account of E. proditor, Osgood (1932) explained why Anteliomys deserves at most subgeneric status within Eothenomys. Karyotype of E. proditor (2n = 32, FN = 56) differs from other Eothenomys so far reported (Yang et al., 1998), and Ye et al. (2002) would exclude it from the genus.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 982, DOI: 10.5281/zenodo.7316535
Health-related quality of life: a retrospective study on local vs. microvascular reconstruction in patients with oral cancer
Creators: name: Meier, J. K.
name: Schuderer, J. G.
name: Zeman, F.
name: Klingelhöffer, Ch.
name: Hullmann, M.
name: Spanier, G.
name: Reichert, T. E.
name: Ettl, T.
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: DONOR-SITE MORBIDITY; NECK-CANCER; PRIMARY SURGERY; FREE-FLAP; OROPHARYNGEAL CANCER; ONCOLOGIC SURGERY; FOREARM FLAP; HEAD; IMPACT; CARCINOMA; Oral carcinoma; Microvascular reconstruction; Health-related quality of life; University of Washington Quality of life questionnaire
subject: 610 Medizin

description: BackgroundNew medicinal and surgical oncological treatment strategies not only improve overall survival rates but continually increase the importance of Health-Related Quality of Life (HRQOL). The purpose of this retrospective cross-sectional study was to analyze HRQOL of patients with oral squamous cell carcinoma after ablative surgery and to evaluate predictive factors for HRQOL outcome.MethodsThe study included 88 patients with histologically confirmed oral squamous cell carcinoma of whom 42 had undergone local reconstruction (LR) and 46 microvascular reconstruction (MVR). During follow-up, all patients completed the University of Washington Quality of Life Questionnaire (UW-QOL) containing 12 targeted questions about the head and neck. Descriptive analyses were made for the tumor site, the T-stage, and adjuvant therapies. HRQOL was compared between the LR and the MVR group with parametric tests. Further analyses were impact of the tumor site, the T-status, and the time from surgery to survey on HRQOL. Statistics also included multivariate correlations and different interaction effects.ResultsHRQOL in the LR group was very good' with 84.313.7 and good' in the MVR group with 73.316.5 points. The physical domains swallowing (p=0.00), chewing (p=0.00), speech (p=0.01), taste (p=0.01), and pain (p=0.04) were significantly worse in the MVR group. An increase in the T-status had a significant negative effect on swallowing (p=0.01), chewing (p=0.01), speech (p=0.03), recreation (p=0.05), and shoulder (p=0.01) in both groups. Regarding the tumor site and subsequent loss of HRQOL, patients with squamous cell carcinoma on the floor of the mouth had significantly worse results in the categories pain (p=0.002), speech (p=0.002), swallowing (p=0.03), activity (p=0.02), and recreation (p=0.01) than patients with tumors in the buccal mucosa. Speech (p=0.03) and pain (p=0.01) had improved 1year after surgery.Conclusion Patients with flap reconstruction because of oral squamous cell carcinoma showed very good overall HRQOL. Outcomes for microvascular reconstruction were good, even in the case of larger defects. The T-status is a predictor for HRQOL. Swallowing, chewing, speaking, taste, and pain were the most important issues in our cohort. Implementing HRQOL questionnaires for the assessment of quality of life could further increase the treatment quality of patients with oral cancer.
Macrostomum rostratum Papi 1951
Creators: name: Diez, Yander L.
name: Schmidt-Rhaesa, Andreas
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Platyhelminthes
Trematoda
Catenulida
Macrostomidae
Macrostomum
Macrostomum rostratum

description: Macrostomum rostratum Papi, 1951
Fig. 3
Known distribution.
Species with a broad known distribution including Europe (United Kingdom, The Netherlands, Germany, Finland, Spain, and Italy) (Papi 1951; Luther 1960; Rixen 1961; Young 1970, 1973; Tulp 1974; Farias et al. 1996; Noreña et al. 2007), Russia (Luther 1960), and Kenya (Young 1976).
Material.
Two specimens studied alive, one preserved in ethanol for future molecular analyses, the second cut in two pieces, the posterior part containing the stylet for whole mounting and the anterior part preserved for molecular analyses. Collected in Wandse river, submerged vegetation with organic matter, 0.1 m deep.
Description. Animals 0.8–0.9 mm long (n = 2), unpigmented and with a pair of eyes (Fig. 3 A, B: e). General morphology corresponds to that in previously described specimens (see Papi 1951). Epidermis fully ciliated, with some larger cilia distributed though the body. False seminal vesicle absent and true seminal vesicle (Fig. 3 C – E: sv) opening into the prostate vesicle (vesicula granulorum). The prostate vesicle (Fig. 3 C – F: pv) opens proximally into the stylet (Fig. 1 A, C – F: st). One specimen had a fully developed stylet, measuring 60 µm in length; it is hook shaped and with the distal part twisted; aperture subdistal and dorsal. Well-developed eggs observed (Fig. 3 A, C: eg).
According to the drawings of Papi (1951: figs 32–33) the stylet of this species measures 42–65 µm, which is in the range of our collected specimen. In other populations recorded from Germany, the stylet is 65–77 µm long (Rixen 1961). The most characteristic traits for this species are the distal turn and the dorsal aperture of the stylet; therefore, we identify our specimen as M. rostratum.
description: Published as part of Diez, Yander L. & Schmidt-Rhaesa, Andreas, 2024, Little neighbours in Hamburg: free-living aquatic flatworms (Platyhelminthes), pp. 279-310 in Evolutionary Systematics 8 (2) on pages 279-310, DOI: 10.3897/evolsyst.8.139468
"zpt_y3_y7.txt" of "A precise measurement of the Z-boson double-differential transverse momentum and rapidity distributions in the full phase space of the decay leptons with the ATLAS experiment at $\sqrt s$ = 8 TeV"
Creators: name: ATLAS Collaboration
Publisher: name: HEPData
Year: 2024

description: Correlation for $p_T$ cross section between 1.2 < |y| < 1.6 and 2.8 < |y| < 3.6
description: CERN-LHC. This paper presents for the first time a precise measurement of the production properties of the $Z$ boson in the full phase space of the decay leptons. This is in contrast to the many previous precise unfolded measurements performed in the fiducial phase space of the decay leptons. The measurement is obtained from proton--proton collision data collected by the ATLAS experiment in 2012 at $\sqrt{s} = 8$ TeV at the LHC and corresponding to an integrated luminosity of 20.2 fb$^{-1}$. The results, based on a total of 15.3 million $Z$-boson decays to electron and muon pairs, extend and improve a previous measurement of the full set of angular coefficients describing $Z$-boson decay. The double-differential cross-section distributions in $Z$-boson transverse momentum $p_T$ and rapidity $y$ are measured in the pole region, defined as $80 < m_{\ell\ell} < 100$ GeV, over the range $|y| < 3.6$. The total uncertainty of the normalised cross-section measurements in the peak region of the $p_T$ distribution is dominated by statistical uncertainties over the full range and increases as a function of rapidity from $0.5-1.0$% for $|y| < 2.0$ to $2-7$% at higher rapidities. The results for the rapidity-dependent transverse momentum distributions are compared to state-of-the-art QCD predictions, which combine in the best cases approximate N$^4$LL resummation with N$^3$LO fixed-order perturbative calculations. The differential rapidity distributions integrated over $p_T$ are even more precise, with accuracies from $0.2-0.3$% for $|y| < 2.0$ to $0.4-0.9$% at higher rapidities, and are compared to fixed-order QCD predictions using the most recent parton distribution functions. The agreement between data and predictions is quite good in most cases.
Potential Use of Gluconate in Cancer Therapy
Creators: name: Mycielska, Maria E.
name: Mohr, Markus T. J.
name: Schmidt, Katharina Maria
name: Drexler, Konstantin
name: Rümmele, Petra
name: Haferkamp, Sebastian
name: Schlitt, Hans J.
name: Gaumann, Andreas
name: Adamski, Jerzy
name: Geissler, Edward K.
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: SODIUM STIBOGLUCONATE; MAGNESIUM INFUSIONS; PHASE-II; IN-VITRO; DISULFIRAM; PREVENTION; ANTIMONY; CALCIUM; CELLS; IMMUNOTHERAPY; gluconate; cancer metabolism; citrate; metabolic targeting; transporter
subject: 610 Medizin

description: We have recently discovered that cancer cells take up extracellular citrate through plasma membrane citrate transporter (pmCiC) and advantageously use citrate for their metabolism. Citrate uptake can be blocked with gluconate and this results in decreased tumor growth and altered metabolic characteristics of tumor tissue. Interestingly, gluconate, considered to be physiologically neutral, is incidentally used in medicine as a cation carrier, but not as a therapeutically active substance. In this review we discuss the results of our recent research with available literature and suggest that gluconate may be useful in the treatment of cancer.
Phyllocoptes taishanensis Xue & Hong 2005
Creators: name: Xue, Xiao-Feng
name: Hong, Xiao-Yue
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Prostigmata
Eriophyidae
Phyllocoptes
Phyllocoptes taishanensis

description: Phyllocoptes taishanensis Xue & Hong, 2005. (Xue & Hong, 2005e)
Phyllocoptes taishanensis Xue & Hong, 2005: 215.
Material examined
10 female and 1 male, from Cedrus deodara (Roxb.) Loud (Pinaceae), Longyuwan (33°42.53’N, 111°45.62’E), Luanchuan County, Henan Province, P. R. China, 19 July 2004, coll. X.­F. Xue.
Relation to host
Vagrant on leaf surface. No damage to the host was observed.
Distribution
China (Shandong, Henan).
description: Published as part of Xue, Xiao-Feng & Hong, Xiao-Yue, 2006, Eriophyoid mite fauna from Henan Province, central China (Acari: Eriophyoidea) with descriptions of five new species, pp. 1-30 in Zootaxa 1204 on page 15, DOI: 10.5281/zenodo.172352
Eothenomys wardi Thomas 1912
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Eothenomys
Eothenomys wardi

description: Eothenomys wardi Thomas 1912
Eothenomys wardi Thomas 1912, Ann. Mag. Nat. Hist., ser. 8, 9: 516.
Type Locality: China, NW Yunnan, Chamutong (= Tra-mu-tang), west of Atunsi, 13,000 ft (Kaneko, 1996 b, provided additional information).
Vernacular Names: Ward's Red-backed Vole.
Distribution: Extreme NW Yunnan in the Mekong and Salween valleys, 2400-4250 m (Corbet and Hill, 1992; Kaneko, 1996 b).
Discussion: E. chinensis species group. Placed in the genus Anteliomys by Hinton (1923). Described as a species by Thomas, recognized as such by Hinton (1923, 1926 a) and Ellerman (1941), but usually included in E. chinensis (G. M. Allen, 1940; Ellerman and Morrison-Scott, 1951; Musser and Carleton, 1993; Pavlinov et al., 1995 a). Corbet and Hill (1992) and Kaneko (1996 b), however, followed Thomas because wardi has a much shorter tail and hind feet, and appreciably smaller auditory bulla than specimens of chinensis, and is latitudinally isolated from that species.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 982, DOI: 10.5281/zenodo.7316535
Identification of the retinoschisin-binding site on the retinal Na/K-ATPase
Creators: name: Ramchandran, Ramani
name: Plössl, Karolina
name: Straub, Kristina
name: Schmid, Verena
name: Strunz, Franziska
name: Wild, Jens
name: Merkl, Rainer
name: Weber, Bernhard H. F.
name: Friedrich, Ulrike
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: X-LINKED RETINOSCHISIS; HOT-SPOTS; PROTEIN RETINOSCHISIN; GENE; RS1; PHOTORECEPTOR; RECEPTORS; RESIDUES; SURFACE;
subject: 570 Biowissenschaften, Biologie
subject: 610 Medizin

description: X-linked juvenile retinoschisis (XLRS) is a hereditary retinal dystrophy, caused by mutations in the RS1 gene which encodes the secreted protein retinoschisin. In recent years, several molecules have been proposed to interact with retinoschisin, including the retinal Na/K-ATPase, L-voltage gated Ca2+ channels, and specific sugars. We recently showed that the retinal Na/K-ATPase consisting of subunits ATP1A3 and ATP1B2 is essential for anchoring retinoschisin to plasma membranes and identified the glycosylated ATP1B2 subunit as the direct interaction partner for retinoschisin. We now aimed to precisely map the retinoschisin binding domain(s) in ATP1B2. In general, retinoschisin binding was not affected after selective elimination of individual glycosylation sites via site-directed mutagenesis as well as after full enzymatic deglycosylation of ATP1B2. Applying the interface prediction tool PresCont, two putative protein-protein interaction patches ("patch I" and "patch II") consisting each of four hydrophobic amino acid stretches on the ATP1B2 surface were identified. These were consecutively altered by site-directed mutagenesis. Functional assays with the ATP1B2 patch mutants identified patch II and, specifically, the associated amino acid at position 240 (harboring a threonine in ATP1B2) as crucial for retinoschisin binding to ATP1B2. These and previous results led us to suggest an induced-fit binding mechanism for the interaction between retinoschisin and the Na/K-ATPase, which is dependent on threonine 240 in ATP1B2 allowing the accommodation of hyperflexible retinoschisin spikes by the associated protein-protein interaction patch on ATP1B2.
Atopida paringa Kiałka & Ruta 2022, sp. nov.
Creators: name: Kiałka, Agata
name: Ruta, Rafał
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scirtidae
Atopida
Atopida paringa

description: Atopida paringa sp. nov.
(Figs 2B, 5N, 13D, 17N)
Type material. Holotype, male (NZAC): “ Lake Paringa \ 6-10.12.60 \ S.Westland ”, “ J.I.Townsend \ & P.R. Kettle ”; paratypes, 16 exx. (NZAC): same data as holotype.
Diagnosis. Body small to moderately big (TL 3.4–4.2 mm), colouration variable, from yellowish brown to dark brown, elytral suture often darkened. Certain identification possible on the basis of male genital characters: lateral plates of penis with minute denticles on outer edge in apical portion, trigonium narrow, much narrower than parameroids, curved laterally; parameroids elongated, apices truncate, with serrated edges, tegmen subrectangular with narrow parameres.
Description. Male. Body elongated, small to moderately big (TL 3.4–4.2 mm), moderately convex. Two types of body colouration—lighter and darker: yellowish brown with darker stripe along elytral suture, head and pronotum darker brown and uniformly dark brown body with lighter brown legs. Punctation on head and pronotum dense, granulate, punctures touching each other, sparser on tubercles in lower part of pronotum. Punctation on elytra simple, coarse, punctures separated by 0.5× diameter of a puncture. Body covered with medium long, protruding, yellowish setae, pointed towards the middle of pronotum. Supraantennal ridges well-marked, elevated triangularly. Pronotum relatively narrow, widest slightly before middle of its length, sides slightly curved, lateral carinae crenulate, anterolateral angles produced, pointed triangularly, posterolateral angles right-angled; base of pronotum with longitudinal depression along posterior margin. Elytra without carinae, humeri well-marked. Ventrite 5 rounded, apex truncate. Penis (L 0.65 mm, W 0.39 mm) elongate, with explanate lateral lobes, outer margin of apical portions of apical plates with minute denticles; trigonium narrow, curved laterally, usually at right angle, shorter than parameroids; parameroids elongated, apices truncate, with serrated edges, apical part covered with punctures; pala wide, triangular, much shorter than parameroids. Tegmen (L 0.67 mm, W 0.39 mm) subrectangular, with narrow rectangular parameres, apices truncate, with scarce punctures and few setae.
Female unknown.
Measurements and ratios. Males (n = 6) TL 3.40–4.20 mm (3.90 mm), PL 0.60–0.75 mm (0.68 mm), PW 0.95–1.15 mm (1.04 mm), EL 2.90–3.45 mm (3.28 mm), EW 1.65–1.95 mm (1.84 mm), TL/EW 2.06–2.15 (2.12), PW/PL 1.36–1.64 (1.53) EL/EW 1.74–1.84 (1.78), EL/PL 4.53–5.00 (4.81), EW/PW 1.68–2.05 (1.77).
Distribution. Known only from the type locality in Westland area of South Island (Fig. 18L).
Etymology. After Lake Paringa area, where the type locality is located.
description: Published as part of Kiałka, Agata & Ruta, Rafał, 2022, Revision of Atopida White, 1846 (Coleoptera: Scirtoidea: Scirtidae), pp. 401-443 in Zootaxa 5174 (4) on page 425, DOI: 10.11646/zootaxa.5174.4.6, http://zenodo.org/record/6986469
Myrmeleon mariaemathildae Pantaleoni, Cesaroni & Nicoli Aldini 2010
Creators: name: Badano, Davide
name: Pantaleoni, Roberto Antonio
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Neuroptera
Myrmeleontidae
Myrmeleon
Myrmeleon mariaemathildae

description: Myrmeleon mariaemathildae Pantaleoni, Cesaroni & Nicoli Aldini, 2010
(Figs. 5F, 6F, 31)
The larva of this antlion was concisely treated in the species description (Pantaleoni et al. 2010).
Examined specimens. Italy. Sardinia, Sorso (Sassari), Platamona, coastal dunes, VIII.2012 (D. Badano), 3 L3. Sardinia, Cabras (Oristano), Tharros, coastal dunes, III.2011 (D. Badano), 1 L3. Tunisia. Tabarka, VII.2006 (R. A. Pantaleoni), 5 L3. Gammarth, VII.2010 (local collector), 1 L3.
Description of 3 rd instar larva. Size (based on 10 specimens): BL 9.28 mm; HL 1.70 mm (1.60–1.81), HW 1.48 mm (1.42–1.57), ML 1.64 mm (1.54–1.80), HW/HL 0.87, ML/HL 0.96. General colouring pale ochre with dark markings, ventral side paler with dark spots; dorsal side of the head capsule with anterior dark markings, lateral sides of the head with small dark marks, ventral side of the head pale with a pair of median spots of variable intensity according to individual (sometimes absent) (Figs. 5F, 31b); mandibles pale brown; legs pale; setae of the body black. Head slightly longer than wide; mandibles as long as the head capsule (Fig. 31a); interdental mandibular setae: (4–5)(1–2)(1–2)(1); dorsal side of the mandible with a sparse covering of short setae on the margins, ventral side of the mandible with few isolated setae at the base. IX abdominal sternite equipped with irregularly disposed ventral digging setae and a row composed by large bristles irregularly interspersed with small setae; rastra not prominent, each bearing 4 digging setae of which the external ones are the longest (Figs. 6F, 31c).
Bio-ecology. The larvae of this recently described species usually colonize open coastal sand dunes with a vegetation covering limited to pioneer psammophilous plants. The pits are normally built in exposed conditions, often at the base of tufts of herbs.
Distribution. Exclusively reported from Sardinia and Tunisia.
Remarks. The larva of M. mariaemathildae is very similar to the closely related M. inconspicuus noticeably differing in the paler colouring of the body and in the IX abdominal sternite. The same characters permit to distinguish this species from other European congeners. In Sardinia, M. mariaemathildae shares similar ecological requirements with M. hyalinus but the two species cohabit only in few sites with moderate anthropic disturbance.
description: Published as part of Badano, Davide & Pantaleoni, Roberto Antonio, 2014, The larvae of European Myrmeleontidae (Neuroptera), pp. 1-71 in Zootaxa 3762 (1) on page 60, DOI: 10.11646/zootaxa.3762.1.1, http://zenodo.org/record/4909357
Isolation of Subtype 3c, 3e and 3f-Like Hepatitis E Virus Strains Stably Replicating to High Viral Loads in an Optimized Cell Culture System
Creators: name: Schemmerer, Mathias
name: Johne, Reimar
name: Erl, Monika
name: Jilg, Wolfgang
name: Wenzel, Jürgen J.
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: LIFE-CYCLE; GENOTYPE; HEV; SOFOSBUVIR; PATIENT; GENOME; IDENTIFICATION; INFECTIVITY; ADAPTATION; RIBAVIRIN; hepatitis E virus; cell culture; whole genome; wild-type HEV isolation; high viral loads
subject: 610 Medizin

description: The hepatitis E virus (HEV) is transmitted via the faecal-oral route in developing countries (genotypes 1 and 2) or through contaminated food and blood products worldwide (genotypes 3 and 4). In Europe, HEV subtypes 3c, 3e and 3f are predominant. HEV is the leading cause of acute hepatitis globally and immunocompromised patients are particularly at risk. Because of a lack of cell culture systems efficiently propagating wild-type viruses, research on HEV is mostly based on cell culture-adapted isolates carrying uncommon insertions in the hypervariable region (HVR). While optimizing the cell culture system using the cell culture-adapted HEV strain 47832c, we isolated three wild-type strains derived from clinical specimens representing the predominant spectrum of HEV in Europe. The novel isolates 14-16753 (3c), 14-22707 (3e) and 15-22016 (3f-like) replicate to high viral loads of 10(8), 10(9) and 10(6.5) HEV RNA copies/mL at 14 days post-inoculation, respectively. In addition, they could be kept as persistently infected cell cultures with constant high viral loads (not approximate to 10(9) copies/mL) for more than a year. In contrast to the latest isolates 47832c, LBPR-0379 and Kernow-C1, the new isolates do not carry genome insertions in the HVR. Optimization of HEV cell culture identified amphotericin B, distinct salts and fetal calf serum (FCS) as important medium supplements. Overconfluent cell layers increased infectivity and virus production. PLC/PRF/5, HuH-7-Lunet BLR, A549 and HepG2/C3A supported replication with different efficiencies. The novel strains and optimized cell culture system may be useful for studies on the HEV life cycle, inactivation, specific drug and vaccine development.
Hyperacrius Miller 1896
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Hyperacrius

description: Hyperacrius Miller 1896
Hyperacrius Miller 1896, N. Amer. Fauna, 12: 54.
Type Species: Arvicola fertilis True 1894
Species and subspecies: 2 species:
Species Hyperacrius fertilis (True 1894)
Species Hyperacrius wynnei (Blanford 1881)
Discussion: Myodini. Assigned to Clethrionomyini by Hooper and Hart (1962) and Gromov and Polyakov (1977); placed in subtribe Myodina, Prometheomyini, by Pavlinov et al. (1995 a) and Pavlinov and Rossolimo (1998). Phylogenetically near Alticola but more fossorial (Corbet, 1978 c; Corbet and Hill, 1992). Taxonomy, geographic distribution, and subspecific classification monographed by Phillips (1969).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 983, DOI: 10.5281/zenodo.7316535
Ambulatory and stationary healthcare use in survivors of ARDS during the first year after discharge from ICU: findings from the DACAPO cohort
Creators: name: Brandstetter, Susanne
name: Dodoo-Schittko, Frank
name: Brandl, Magdalena
name: Blecha, Sebastian
name: Bein, Thomas
name: Apfelbacher, Christian
name: DACAPO, study group
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: RESPIRATORY-DISTRESS-SYNDROME; QUALITY-OF-LIFE; OUTCOMES; COSTS; SYMPTOMS; PATTERNS; GERMANY; SEPSIS; SCORE; Healthcare use; Ambulatory health care; Stationary health care; Health services research; ARDS; Critical illness; Post-ICU
subject: 610 Medizin

description: BackgroundFor many survivors of acute respiratory distress syndrome (ARDS), the process from discharge from intensive care unit (ICU) to recovery is long and difficult. However, healthcare use after discharge from ICU has received only little attention by research. This study sets out to investigate the extent of ambulatory and stationary healthcare use among survivors of ARDS in Germany (multicenter DACAPO cohort) and to analyze predictors of stationary healthcare use.ResultsA total of 396 survivors of ARDS provided data at 1year after discharge from ICU. Fifty percent of 1-year survivors were hospitalized for 48days or longer after discharge from ICU, with 10% spending more than six out of 12 months in stationary care. The duration of hospitalization increased significantly by the length of the initial ICU stay. All participants reported at least one outpatient visit (including visits to general practitioners), and 50% contacted four or more different medical specialties within the first year after discharge from ICU.ConclusionsFor most of the patients, the first year after ARDS is characterized by an extensive amount of healthcare utilization, especially with regard to stationary health care. These findings shed light on the substantial morbidity of patients after ARDS and contribute to a better understanding of the situation of patients following discharge from ICU.
Abacarus wuyiensis Kuang & Zhuo 1987
Creators: name: Xue, Xiao-Feng
name: Hong, Xiao-Yue
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Prostigmata
Eriophyidae
Abacarus
Abacarus wuyiensis

description: Abacarus wuyiensis Kuang & Zhuo, 1987. (Kuang & Zhuo, 1987)
Abacarus wuyiensis Kuang & Zhuo, 1987: 380 –381.
Abacarus wuyiensis Kuang & Zhuo. Kuang, 1995: 144.
Material examined
11 females, from Bambusa sp. (Gramineae). Baotianman (33°31.00’N, 111°55.85’E), Neixiang County, Henan Province, P. R. China, 22 July 2004, coll. X.­F. Xue.
Relation to host
Vagrant on leaf surface. No damage to the host was observed.
Distribution
China (Fujian, Guangxi, Jiangsu, Henan).
description: Published as part of Xue, Xiao-Feng & Hong, Xiao-Yue, 2006, Eriophyoid mite fauna from Henan Province, central China (Acari: Eriophyoidea) with descriptions of five new species, pp. 1-30 in Zootaxa 1204 on page 15, DOI: 10.5281/zenodo.172352