cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Liquid diffraction analysis of sarcoplasmic reticulum. II. Solvent electron contrast variation.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1982

description: Intensities of x-ray scattering from rabbit muscle sarcoplasmic reticulum membrane have been measured over the range of s = 0.05-0.25, at solvent densities varying between p0 = 0.335 and 0.389 electrons/A3. Analysis of the results shows agreement with the elements of structure deduced earlier by a different technique, based on the variation of the lipid-protein concentration ratio. In addition, the present work extends the analysis to allow isolation of the lipid contribution to the total scattering, from which a profile of the lipid electron density normal to the membrane face is evaluated. The scattering arising from electron correlations within the plane of the bilayer has also been identified.
A cross-sectional analysis of radiographic ankle osteoarthritis frequency and associated factors: The Johnston County osteoarthritis project
Creators: name: Lateef, S.
name: Jordan, J.M.
name: Renner, J.B.
name: Nelson, A.E.
name: Golightly, Y.M.
Publisher: name: Journal of Rheumatology
Year: 2017

description: Objective. Because there are no epidemiologic data regarding the frequency of ankle osteoarthritis (OA) in a general population, we sought to analyze this disabling condition in a large, well-characterized, community-based cohort of older individuals. Methods. Cross-sectional data, including ankle radiographs, were from the most recent data collection (2013-2015) of the Johnston County OA Project. Radiographic ankle OA (rAOA) was defined as a Kellgren-Lawrence arthritis grading scale of ≥ 2 on weight-bearing lateral and mortise radiographs. The presence of pain, aching, or stiffness in the ankles as well as history of ankle injury (limiting ability to walk for at least 2 days) were assessed. Chi-square statistics (categorical variables) and Student t tests (continuous variables) were used to compare all participant characteristics by rAOA status. Joint-based logistic regression models with generalized estimating equations were used to examine associations of rAOA and covariates of interest [age, body mass index (BMI), sex, race, ankle symptoms, and injury history]. Results. Of 864 participants with available data, 68% were women, 34% were African American, with a mean age of 72 years and BMI of 31 kg/m2. Nearly 7% of this sample had rAOA. Increasing age, high BMI, history of ankle injury, and presence of ankle symptoms were all independently associated with greater odds of having rAOA; no significant differences were seen by sex or race. Conclusion. The frequency of rAOA was higher than estimates generally quoted in the literature. While injury was an important contributor, other factors such as age, BMI, and symptoms were also significantly associated with rAOA.
Contents
Creators: name: Wade, Sally
name: Walton, Kerry
Publisher: name: FUTURESCAN
Year: 2019
Subjects: subject: 120306 Textile and Fashion Design
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: Contents page for the Association of Fashion and Textile Courses (FTC) post-conference publication Futurescan: Mapping the Territory.
Futurescan: Mapping the Territory
Edited by Sally Wade and Kerry WaltonFebruary 2011ISBN: 978 1 907382 30 7
The selected contributions and research papers for this publication were presented at the Foresight Centre, University of Liverpool, 17-18 November 2009.
Additional file 2 of Experienced based co design: nursing preceptorship educational programme
Creators: name: Hardie, Philip
name: Murray, Aidan
name: Jarvis, Suzi
name: Redmond, Catherine
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy
subject: Hematology

description: Additional file 2. Student, Preceptor & Patient Touchpoints and overarching target behaviours to include in educational programme.
Antibody Drug Design
Creators: name: Vivian Smith
Publisher: name: Zenodo
Year: 2024

description: CD ComputaBio is a leading global company providing compelling and novel solutions in computer-aided drug design. We prioritize the integration of our advanced computational capabilities with our extensive expertise in antibody drug design to offer a range of services. These services aim to accelerate drug discovery and development processes by providing our clients with meticulously tailored, reliable, accurate projections while ensuring time and cost-effectiveness.
Pseudospherical surfaces with singularities
Creators: name: Brander, David
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: Primary 53A05, 53C43, Secondary 53C42

description: We study a generalization of constant Gauss curvature -1 surfaces in Euclidean 3-space, based on Lorentzian harmonic maps, that we call pseudospherical frontals. We analyze the singularities of these surfaces, dividing them into those of characteristic and non-characteristic type. We give methods for constructing all non-degenerate singularities of both types, as well as many degenerate singularities. We also give a method for solving the singular geometric Cauchy problem: construct a pseudospherical frontal containing a given regular space curve as a non-degenerate singular curve. The solution is unique for most curves, but for some curves there are infinitely many solutions, and this is encoded in the curvature and torsion of the curve.
description: 26 pages, 11 figures. Version 3: examples added (new Section 6). Introduction section revised
Defining the Burden of Osteoarthritis in Population-Based Surveys
Creators: name: Allen, K.D.
name: Jordan, J.M.
name: Golightly, Y.M.
Publisher: name: John Wiley and Sons Inc.
Year: 2016

description: Osteoarthritis (OA) is a leading cause of disability and a common chronic health condition. The burden of OA on the current health care system is significant and growing. By the year 2030, the rate of knee replacements to treat knee OA (the most common type of OA) is expected to rapidly increase to more than 3 million people per year, costing $14.3 billion annually. In this issue of Arthritis Care & Research, the authors of “Alternative Methods for Defining Osteoarthritis and the Impact on Estimating Prevalence in a US Population-Based Survey” correctly report that available prevalence estimates of OA from large national survey data are outdated. Data from population-based cohort studies suggest that OA prevalence has risen during recent decades and may be higher than previously estimated. Additionally, data from the National Health and Nutrition Examination Surveys (NHANES) show an increase in knee pain from the 1970s to the 1990s, which may be linked to escalating knee OA prevalence. Given the impact of OA on disability and its burden on health care, updated estimates of the prevalence of OA are needed.
Agonists Bay-K8644 and CGP-28392 open calcium channels reconstituted from skeletal muscle transverse tubules
Creators: name: Affolter, H.
name: Coronado, R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1985

description: The recently described calcium channel agonists Bay-K8644 and CGP-28392 have been used to induce long-term opening of calcium channels from purified rat muscle transverse tubules (t-tubules) incorporated into planar phospholipid bilayers. Agonist-open channels are selective for divalent cations (except Mg++), display voltage-dependent kinetics, and are blocked by the calcium channel antagonist, nitrendipine. The sensitivity to dihydropyridine agonists and antagonists indicate that a pool of t-tubule calcium channels remain functional after membrane fractionation and purification.
Additional file 3 of Experienced based co design: nursing preceptorship educational programme
Creators: name: Hardie, Philip
name: Murray, Aidan
name: Jarvis, Suzi
name: Redmond, Catherine
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy
subject: Hematology

description: Additional file 3. GRIPP2 PPI reporting Checklist.
Effect of divalent cations on the assembly of neutral and charged phospholipid bilayers in patch-recording pipettes
Creators: name: Coronado, R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1985

description: Monolayers of the negatively charged phospholipid phosphatidylserine (PS) and of the amphoteric phospholipid dioleoylphosphatidylethanolamine (DOPE) were used to assemble bilayers at the tip of patch-recording pipettes. PS bilayers, with seal resistances in the range of gigaohmns (gigaseals), could only be generated when millimolar concentration of divalent cations, Ca++, Mg++, or Ba++ were present in the pipette and bath solutions. In contrast, gigaseals of DOPE were independent of divalent ion concentration in the pH range where DOPE is predominantly neutral (pH 6.5) or positively charged (pH 1.5). At pH 10.0, when most DOPE molecules bear a net negative charge, gigaseals became divalent cation dependent, in a manner quantitatively similar to that of PS at neutral pH. The results indicate that divalent cations play an important role in stabilizing gigaseals of negatively charged lipid but are of no consequence in neutral or positively charged seals.
Factors associated with hallux valgus in a community-based cross-sectional study of adults with and without osteoarthritis
Creators: name: Renner, J.B.
name: Jordan, J.M.
name: Dufour, A.B.
name: Golightly, Y.M.
name: Hannan, M.T.
Publisher: name: John Wiley and Sons Inc
Year: 2015

description: Objective To determine whether hallux valgus (HV) was associated with potential risk factors, including foot pain in a large, biracial cohort of older men and women. Methods We conducted a cross-sectional analysis of cohort members of the Johnston County Osteoarthritis Project, of whom 1,502 had complete clinical and demographic data available (mean age 68 years, mean body mass index [BMI] 31.3 kg/m2, 68% women, and 30% African American). The presence of HV was assessed visually using a validated examination. Multivariate logistic regression models with generalized estimating equations for the total sample and for each sex and race subgroup were used to examine the effect of age, BMI, foot pain, pes planus, and knee or hip radiographic osteoarthritis (OA) on HV. Results HV was present in 64% of the total sample (69% for African American men, 70% for African American women, 54% for white men, and 65% for white women). The association between HV and foot pain was elevated but not statistically significant (adjusted odds ratio [aOR] 1.21, 95% confidence interval 0.99-1.47). Women, African Americans, older individuals, and those with pes planus or knee/hip OA had significantly higher odds of HV (aOR 1.17-1.48). Participants with higher BMI had lower odds of HV compared to those with normal BMI (aOR 0.54-0.72). Overall, patterns of associations were similar across subgroups. Conclusion HV was associated with female sex, African American race, older age, pes planus, and knee/hip OA, and inversely associated with higher BMI. Early prevention and intervention approaches may be needed in high-risk groups; longitudinal studies would inform these approaches.
Futurescan - Author Contact Details
Creators: name: Wade, Sally
name: Walton, Kerry
Publisher: name: FUTURESCAN
Year: 2019
Subjects: subject: 120306 Textile and Fashion Design
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: Author names and affiliations for Futurescan: Mapping the Territory.
Edited by Sally Wade and Kerry WaltonFebruary 2011ISBN: 978 1 907382 30 7
The selected contributions and research papers for this publication were presented at the Foresight Centre, University of Liverpool, 17-18 November 2009.
7 Big Concepts to Learn About in Materials Engineering
Creators: John A. Nychka
Publisher: name: University of Alberta Library
Year: 2016

Materials engineers specialize in knowing which materials to use in different applications, why certain materials should be used, how to make materials, how to test and characterize materials, and how to design and test new materials. Successful application of such knowledge leads to safe, predictable, and reliable use of materials, which are major goals of the engineering profession. The big concepts listed herein are essential for effective use of engineering materials (solid matter), and they epitomize our materials paradigm (an accepted way to think about materials—a set of relationships).
Membrane structural domains. Resolution limits using diphenylhexatriene fluorescence decay
Creators: name: Lentz, B. R.
name: Barrow, D. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1985

description: Measurement of multiple fluorescence decay times of 1,6-diphenyl-1,3,5-hexatriene (DPH) in membranes can in principle be used to investigate structural domains of lipid bilayers. To assess the feasibility of this approach using phase and modulation techniques, we reduced experimental errors specifically associated with performing these measurements on membrane suspensions (probe self-quenching, background fluorescence, turbidity-induced artifacts) and determined empirically the level of precision thereby obtainable. Next we used these precision limits in theoretical calculations to conclude that the ratio of two coexisting decay times must exceed 1.3 if they are to be resolved with reliable accuracy. To demonstrate that such resolutions could be accomplished experimentally in membrane suspensions, three approaches were taken. First, the fluorescence decay of aqueous quinine sulfate quenched by chloride ion was resolved from that of membrane-associated DPH as long as the lifetime ratios of these two fluorophores exceeded the predicted value. Second, populations of DPH-containing lipid vesicles with single (or nearly single) decay times were mixed together, and when there were only two major lifetime components that differed by more than 30%, the resulting heterogeneous fluorescence could be resolved into the two expected lifetime components. Finally, DPH fluorescence decay measurements were correlated with phase behavior in well-characterized lipid systems, revealing a short lifetime component of DPH fluorescence associated with gel-phase lipid vesicles. From these studies, we conclude that only in special cases can co-existing gel and fluid phases be resolved by means of DPH lifetime heterogeneity, within the limits of precision defined herein.
Trihothyas (Kashmirothyas) hutchinsoni Lundblad 1934
Creators: name: Pešić, Vladimir
name: Chatterjee, Tapas
name: Bordoloi, Sabitry
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Hydryphantidae
Trihothyas
Trihothyas hutchinsoni

description: Trihothyas (Kashmirothyas) hutchinsoni Lundblad, 1934
Records from the study area: Kashmir—“ Kashmirothyas hutchinsoni “ Lundblad (1934), “ Octolundbladia ladakiana ” Vitzthum (1942).
Habitat: Mountain streams and springs.
Distribution: India.
description: Published as part of Pešić, Vladimir, Chatterjee, Tapas & Bordoloi, Sabitry, 2010, A checklist of the water mites (Acari: Hydrachnidia) of India, with new records and description of one new species, pp. 1-54 in Zootaxa 2617 (1) on page 7, DOI: 10.11646/zootaxa.2617.1.1, http://zenodo.org/record/197964
Characteristics associated with hallux valgus in a population-based foot study of older adults
Creators: name: Dufour, A.B.
name: Golightly, Y.M.
name: Casey, V.A.
name: Hannan, M.T.
Publisher: name: John Wiley and Sons Inc
Year: 2014

description: Objective. Hallux valgus (HV) is common in older adults, but limited studies of risk factors have reported conflicting results. This cross-sectional analysis examined the association of HV with foot pain and other characteristics in older adults. Methods. The population-based Framingham Foot Study assessed HV, foot pain, foot structure (planus, rectus, and cavus), current and past high-heeled shoe use, age, and body mass index (BMI). Sex-specific logistic and multinomial logistic regression examined the association of HV and HV with pain with study variables.  Results. Of 1,352 men and 1,725 women (mean ± SD age 66 ± 10.5 years), 22% of men and 44% of women had HV, and 3% of men and 11% of women had HV with pain. Foot pain increased the odds of HV in both sexes (P < 0.05). In women, older age and past high-heeled shoe use increased the odds of HV by 27% and 47%, respectively (P < 0.01), and cavus foot structure decreased the odds of HV by 26% (P = 0.02). BMI >30 kg/m2 decreased the odds of HV by 33% in men and 45% in women (P < 0.05). In women only, odds of pain and HV versus no pain and no HV were greater with older age and planus foot structure. Conclusion. Our work showed different associations in participants who had HV with pain compared to those without foot pain. In both men and women, strong associations were observed between HV and foot pain and inversely with BMI. Older age was associated with HV in women only, as were protective associations with cavus foot structure.
Generating collective counterfactual explanations in score-based classification via mathematical optimization
Creators: name: Carrizosa, Emilio
name: Ramírez-Ayerbe, Jasone
name: Morales, Dolores Romero
Publisher: name: arXiv
Year: 2023
Subjects: subject: Machine Learning (stat.ML)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Due to the increasing use of Machine Learning models in high stakes decision making settings, it has become increasingly important to have tools to understand how models arrive at decisions. Assuming a trained Supervised Classification model, explanations can be obtained via counterfactual analysis: a counterfactual explanation of an instance indicates how this instance should be minimally modified so that the perturbed instance is classified in the desired class by the Machine Learning classification model. Most of the Counterfactual Analysis literature focuses on the single-instance single-counterfactual setting, in which the analysis is done for one single instance to provide one single explanation. Taking a stakeholder's perspective, in this paper we introduce the so-called collective counterfactual explanations. By means of novel Mathematical Optimization models, we provide a counterfactual explanation for each instance in a group of interest, so that the total cost of the perturbations is minimized under some linking constraints. Making the process of constructing counterfactuals collective instead of individual enables us to detect the features that are critical to the entire dataset to have the individuals classified in the desired class. Our methodology allows for some instances to be treated individually, performing the collective counterfactual analysis for a fraction of records of the group of interest. This way, outliers are identified and handled appropriately. Under some assumptions on the classifier and the space in which counterfactuals are sought, finding collective counterfactuals is reduced to solving a convex quadratic linearly constrained mixed integer optimization problem, which, for datasets of moderate size, can be solved to optimality using existing solvers. The performance of our approach is illustrated on real-world datasets, demonstrating its usefulness.
description: This research has been funded in part by research projects EC H2020 MSCA RISE NeEDS (Grant agreement ID: 822214), FQM-329, P18-FR-2369 and US-1381178 (Junta de Andaluc\'{\i}a, Spain), and PID2019-110886RB-I00 and PID2022-137818OB-I00 (Ministerio de Ciencia, Innovaci\'on y Universidades, Spain). This support is gratefully acknowledged
Modulation of aminopyridine block of potassium currents in squid axon
Creators: name: Yeh, J. Z.
name: Kirsch, G. E.
name: Oxford, G. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1986

description: Aminopyridines are known to block potassium (K) currents in excitable membranes in a manner dependent upon membrane potential, such that the block is relieved by depolarization and restored upon repolarization. In the present study, the effects of aminopyridines on voltage-dependent potassium (K) channels were examined in internally perfused, voltage-clamped squid giant axons. The time course of block restoration after conditioning depolarization was found to be modulated by membrane electric field, K-channel gating, and external cations. Depolarized holding potentials accelerated block restoration without altering steady-state block levels, suggesting that the voltage dependence of block restoration may be related to K channel gating rather than drug binding per se. In support of this notion, low external calcium concentration, which shifts the voltage dependence of K-channel gating to more negative potentials, also accelerated block restoration. Conversely, the relationship between the rate of block restoration and membrane holding potential was shifted in the depolarizing direction by phloretin, an agent that shifts the dependence of K-channel opening on membrane potential in a similar manner. Modification of K-channel gating also was found to alter the rate of block restoration. Addition of internal zinc or internal treatment with glutaraldehyde slowed the time course of both K-channel activation and aminopyridine block restoration. Aminopyridines also were found to interact in the K channel with external Cs+, NH4+, and Rb+, each of which slowed aminopyridine block restoration. Our results suggest that aminopyridines enter and occlude K channels, and that the availability of the binding site may be modulated by channel gating such that access is limited by the probability of the channel reaching an intermediate closed state at the resting potential.
Stationary currents in particle systems with constrained hopping rates
Creators: name: Cirillo, Emilio N. M.
name: Colangeli, Matteo
name: Muntean, Adrian
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We study the effect on the stationary currents of constraints affecting the hopping rates in stochastic particle systems. In the framework of Zero Range Processes with drift within a finite volume, we discuss how the current is reduced by the presence of the constraint and deduce exact formulae, fully explicit in some cases. The model discussed here has been introduced in Ref. [1] and is relevant for the description of pedestrian motion in elongated dark corridors, where the constraint on the hopping rates can be related to limitations on the interaction distance among pedestrians.
Additional file 1 of Cardiac device to plug an aorto-bronchial fistula
Creators: name: Ahmadi, Somaye
name: Sadeghipour, Parham
name: Mohebbi, Bahram
name: Rabiei, Parham
name: Parham, Maryam
name: Rahmanpour, Hamid Reza
name: Moosavi, Jamal
Publisher: name: figshare
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1.
Race and sex differences in willingness to undergo total joint replacement: The Johnston County Osteoarthritis Project
Creators: name: Allen, K.D.
name: Golightly, Y.M.
name: Ibrahim, S.A.
name: Kwoh, C.K.
name: Renner, J.B.
name: Jordan, J.M.
name: Callahan, L.F.
name: Helmick, C.G.
Publisher: name: John Wiley and Sons Inc.
Year: 2014

description: Objective Using data from the community-based Johnston County Osteoarthritis Project, we examined race and sex variations in willingness to undergo, and perceptions regarding, total joint replacement (TJR). Methods Analyses were conducted for the total sample who participated in a followup measurement period from 2006-2010 (n = 1,522) and a subsample with symptomatic hip and/or knee osteoarthritis (sOA; n = 445). Participants indicated how willing they would be to have TJR (hip or knee) if their doctor recommended it; responses were categorized as "definitely" or "probably" willing versus "unsure," "probably not," or "definitely not" willing, or "don't know." Participants answered 7 questions regarding perceptions of TJR outcomes. Multivariable logistic regression models of willingness included participant characteristics (including socioeconomic status) and TJR perception variables that were associated with willingness at the P < 0.1 level in bivariate analyses. Results African Americans had lower odds of willingness to undergo TJR than whites in the total sample (adjusted odds ratio [OR] 0.47 [95% confidence interval (95% CI) 0.31-0.72]) and the sOA subsample (adjusted OR 0.42 [95% CI 0.25-0.69]). There were no sex differences in willingness. African Americans expected poorer TJR outcomes than whites, but sex differences were minimal; perceptions of TJR outcomes were not significantly associated with willingness. Conclusion In this community sample, race differences in TJR willingness and perceptions were substantial, but sex differences were small. Perceptions of TJR did not appear to affect willingness or explain race differences in willingness.
The Optimal Rubbling Number of Ladders, Prisms and Möbius-ladders
Creators: name: Katona, Gyula Y.
name: Papp, László F.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: G.2.2
subject: 05C85, 05C57

description: A pebbling move on a graph removes two pebbles at a vertex and adds one pebble at an adjacent vertex. Rubbling is a version of pebbling where an additional move is allowed. In this new move, one pebble each is removed at vertices $v$ and $w$ adjacent to a vertex $u$, and an extra pebble is added at vertex $u$. A vertex is reachable from a pebble distribution if it is possible to move a pebble to that vertex using rubbling moves. The optimal rubbling number is the smallest number $m$ needed to guarantee a pebble distribution of $m$ pebbles from which any vertex is reachable. We determine the optimal rubbling number of ladders ($P_n\square P_2$), prisms ($C_n\square P_2$) and Möblus-ladders.
Measurement of Severe Acute Respiratory Syndrome Coronavirus 2 Antigens in Plasma of Pediatric Patients With Acute Coronavirus Disease 2019 or Multisystem Inflammatory Syndrome in Children Using an Ultrasensitive and Quantitative Immunoassay
Creators: name: Randolph, A.G.
name: Romero, D.
name: Cullimore, M.L.
name: Staat, M.A.
name: Schwartz, S.P.
name: Loftis, L.L.
name: Zhang, Y.
name: Schuster, J.E.
name: Joerger, J.
name: Fitzgerald, J.C.
name: Walker, T.C.
name: Crandall, H.
name: Tarquinio, K.M.
name: Pollock, N.R.
name: Joe, J.
name: Gertz, S.J.
name: Halasa, N.B.
name: Zinter, M.S.
name: Padmanabhan, N.
name: Manjula, N.
name: Coates, B.M.
name: Allegri-Machado, G.
name: Maddux, A.B.
name: Bathala, P.
name: Novak, T.
name: Irby, K.
name: Sigal, G.B.
name: Chou, J.
name: Mathew, A.
name: Overcoming COVID-19 Investigators
name: Flori, H.R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: BACKGROUND: Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigens in blood has high sensitivity in adults with acute coronavirus disease 2019 (COVID-19), but sensitivity in pediatric patients is unclear. Recent data suggest that persistent SARS-CoV-2 spike antigenemia may contribute to multisystem inflammatory syndrome in children (MIS-C). We quantified SARS-CoV-2 nucleocapsid (N) and spike (S) antigens in blood of pediatric patients with either acute COVID-19 or MIS-C using ultrasensitive immunoassays (Meso Scale Discovery). METHODS: Plasma was collected from inpatients (<21 years) enrolled across 15 hospitals in 15 US states. Acute COVID-19 patients (n = 36) had a range of disease severity and positive nasopharyngeal SARS-CoV-2 RT-PCR within 24 hours of blood collection. Patients with MIS-C (n = 53) met CDC criteria and tested positive for SARS-CoV-2 (RT-PCR or serology). Controls were patients pre-COVID-19 (n = 67) or within 24 hours of negative RT-PCR (n = 43). RESULTS: Specificities of N and S assays were 95-97% and 100%, respectively. In acute COVID-19 patients, N/S plasma assays had 89%/64% sensitivity; sensitivities in patients with concurrent nasopharyngeal swab cycle threshold (Ct) ≤35 were 93%/63%. Antigen concentrations ranged from 1.28-3844 pg/mL (N) and 1.65-1071 pg/mL (S) and correlated with disease severity. In MIS-C, antigens were detected in 3/53 (5.7%) samples (3 N-positive: 1.7, 1.9, 121.1 pg/mL; 1 S-positive: 2.3 pg/mL); the patient with highest N had positive nasopharyngeal RT-PCR (Ct 22.3) concurrent with blood draw. CONCLUSIONS: Ultrasensitive blood SARS-CoV-2 antigen measurement has high diagnostic yield in children with acute COVID-19. Antigens were undetectable in most MIS-C patients, suggesting that persistent antigenemia is not a common contributor to MIS-C pathogenesis.
Flexible Space & Built Pedagogy: Emerging IT Embodiments
Creators: name: Monahan, Torin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: This paper analyzes the convergence of information technology infrastructures and traditional educational spaces and proposes flexible criteria for material-virtual, hybrid learning environments.  I develop the concept of built pedagogy to account for the ways that built environments teach values through their constraints upon social action and interaction and suggest ways that the built pedagogies of hybrid spaces can facilitate learning by inviting students and teachers to participate in the continual re-design of learning structures.
Additional file 1 of Association between radiographic hand osteoarthritis and bone microarchitecture in a population-based sample
Creators: name: Ma, Canchen
name: Aitken, Dawn
name: Wu, Feitong
name: Squibb, Kathryn
name: Cicuttini, Flavia
name: Jones, Graeme
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Hematology

description: Additional file 1: Supplementary Figure 1. Example HRpQCT scans of right 2nd PIP joint. a) and b) are 3D and axial images (respectively) from a patient (male, 78 years) with an osteophyte score grade of 0. Supplementary Figure 2. Example HRpQCT scans of right 1st CMC joint. a) and b) are 3D and axial images (respectively) from a patient (male, 78 years) with an osteophyte score grade of 0.
Single-channel calcium and barium currents of large and small conductance from sarcoplasmic reticulum
Creators: name: Coronado, R.
name: Smith, J. S.
name: Meissner, G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1986

description: Two types of divalent cation conducting channels from rabbit skeletal muscle sarcoplasmic reticulum (SR) were incorporated into planar lipid bilayers. A high conductance (100 pS in 53 mM trans Ca2+) Ca2+ channel was incorporated from heavy density SR fractions. The 100-pS channel was activated by adenine nucleotides and Ca2+ and inhibited by Mg2+ and ruthenium red. A 10-pS calcium and barium conducting channel could be incorporated into planar lipid bilayers from light, intermediate, and heavy density SR vesicles. 10-pS channel activity in bilayers was not dependent on cis Ca2+ and was only weakly dependent on adenine nucleotides. Ruthenium red at concentrations up to 1 mM had no effect and Mg2+ was only marginally effective in inhibiting macroscopic Ba2+ currents from this channel. Calcium releasing activity in intermediate and heavy density SR fractions was assayed according to a rapid quench protocol and compared with the results obtained in the bilayer. Results from this comparison indicate that the 10-pS channel is probably not involved in rapid Ca2+- and adenine nucleotide-induced Ca2+ release from isolated SR vesicles.
Capped Accumulated Return Call Option
Creators: name: Lee, David
Publisher: name: Zenodo
Year: 2022
Subjects: Capped Accumulated Return Call Option

description: We propose a Monte Carlo (Gaussian MC and Quasi MC) pricing model for the product named capped-accumulated-return-call (CARC) with lock in feature.
description: https://finpricing.com/lib/FxAccumulator.html
Additional file 2 of Association between radiographic hand osteoarthritis and bone microarchitecture in a population-based sample
Creators: name: Ma, Canchen
name: Aitken, Dawn
name: Wu, Feitong
name: Squibb, Kathryn
name: Cicuttini, Flavia
name: Jones, Graeme
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Hematology

description: Additional file 2: Supplementary Table 1. Bone parameters, abbreviation, unit, description and measure methods.
DEVELOPING EMPLOYABILllY WITHIN FASHION AND TEXTILES CURRICULA
Creators: name: O'Connor, Cassandra
Publisher: name: FUTURESCAN
Year: 2019
Subjects: subject: 120306 Textile and Fashion Design
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: This research paper was presented at Futurescan: Mapping the Territory, Foresight Centre, University of Liverpool, 17-18 November 2009.

Futurescan: Mapping the Territory
Edited by Sally Wade and Kerry WaltonFebruary 2011ISBN: 978 1 907382 30 7
Aminopyridines block an inactivating potassium current having slow recovery kinetics
Creators: name: Wagoner, P. K.
name: Oxford, G. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: The blocking action of aminopyridines on an inactivating K current (lKi) in GH3 pituitary cells was studied before and after altering the macroscopic decay of the current with N-bromoacetamide (NBA). The first depolarizing pulse delivered either seconds or minutes after beginning 4-aminopyridine (4AP) application, elicited a current with both a more rapid decay and a reduced peak amplitude. The rapid decay (or time-dependent block) was especially prominent in NBA-treated cells. With continued drug application, subsequent test pulses revealed a stable block of peak current, greater in NBA-treated than control cells. Recovery from block was enhanced by hyperpolarizing holding potentials and by the first depolarizing pulse delivered after prolonged recovery intervals. Unlike aminopyridine block of other K currents, there was no convincing evidence for voltage shifts in activation or inactivation, or for voltage and frequency-dependent unblock. Increasing the open probability of the channels did, however, facilitate the block. Although the behavior of currents in 4AP was suggestive of "open channel block," the block was not produced by 4-aminopyridine methiodide, a positively charged aminopyridine. Moreover, because partial block and recovery occurred without opening the channels we suggest that aminopyridines bind to, or near, this K channel, that this binding is enhanced by opening the channel, and that a conformational change is induced which mimics inactivation. Because recovery from block is enhanced by negative potentials, we suggest that aminopyridine molecules may become "trapped" by inactivation awaiting the slow process of reactivation to escape their binding sites.
Cyclic Group Actions on Contractible 4-Manifolds
Creators: name: Anvari, Nima
name: Hambleton, Ian
Publisher: name: arXiv
Year: 2014
Subjects: subject: Geometric Topology (math.GT)
subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics
subject: 57M60, 57N13, 57R57, 57S17

description: There are known infinite families of Brieskorn homology 3-spheres which can be realized as boundaries of smooth contractible 4-manifolds. In this paper we show that free periodic actions on these Brieskorn spheres do not extend smoothly over a contractible 4-manifold. We give a new infinite family of examples in which the actions extend locally linearly but not smoothly.
description: 20 pages: final version, to appear in Geometry & Topology
THE USE OF COLOUR TO MANIPULATE PATTERN IN KNITTED FABRICS
Creators: name: Gaston, Elizabeth
Publisher: name: FUTURESCAN
Year: 2019
Subjects: subject: 120306 Textile and Fashion Design
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: This research paper was presented at Futurescan: Mapping the Territory, Foresight Centre, University of Liverpool, 17-18 November 2009.

Futurescan: Mapping the Territory
Edited by Sally Wade and Kerry WaltonFebruary 2011ISBN: 978 1 907382 30 7
Characterization of ultradifferentiable test functions defined by weight matrices in terms of their Fourier transform
Creators: name: Schindl, Gerhard
Publisher: name: arXiv
Year: 2015
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 46A13 (Primary), 26E10, 30D60, 46E10 (Secondary)

description: We prove that functions with compact support in non-quasianalytic classes of Roumieu-type and of Beurling-type defined by a weight matrix with some mild regularity conditions can be characterized by the decay properties of their Fourier transform. For this we introduce the abstract technique of constructing from the original matrix multi-index matrices and associated function spaces. We study the behaviour of this construction in detail and characterize its stability. Moreover non-quasianalyticity of the classes is characterized.
description: 25 pages This version is accepted for publication in Note di Matematica
Looking at proteins: representations, folding, packing, and design. Biophysical Society National Lecture, 1992
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1992

description: Looking at proteins is an active process of interpretation and selection, emphasizing some features and deleting others. Multiple representations are needed, for such purposes as showing motions or conveying both the chain connectivity and the three-dimensional shape simultaneously. In studying and comparing protein structures, ideas are suggested about the determinants of tertiary structure and of folding (e.g., that Greek key beta barrels may fold up two strands at a time). The design and synthesis of new proteins "from scratch" provides a route toward the experimental testing of such ideas. It has also been a fruitful new perspective from which to look at structures, requiring such things as statistics on very narrowly defined structural categories and explicit attention to "negative design" criteria that actively block unwanted alternatives (e.g., reverse topology of a helix bundle, or edge-to-edge aggregation of beta sheets). Recently, the field of protein design has produced a rather unexpected general result: apparently we do indeed know enough to successfully design proteins that fold into approximately correct structures, but not enough to design unique, native-like structures. The degree of order varies considerably, but even the best designed material shows multiple conformations by NMR, more similar to a "molten globule" folding intermediate than to a well ordered native tertiary structure. In response to this conclusion, we are now working on systems that test useful questions with approximate structures (such as determining which factors most influence the choice of helix-bundle topology) and also analyzing how natural proteins achieve unique core conformations (e.g., for side chains on the interior side of a beta sheet, illustrated in the kinemages).
The fastest contracting muscles of nonmammalian vertebrates express only one isoform of the ryanodine receptor
Creators: name: O'Brien, J.
name: Meissner, G.
name: Block, B. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: The skeletal muscles of chickens, frogs, and fish have been reported to express two isoforms (alpha and beta) of the sarcoplasmic reticulum calcium release channel (ryanodine receptor or RYR), while mammals express only one. We have studied patterns of RYR isoform expression in skeletal muscles from a variety of fish, reptiles, and birds with immunological techniques. Immunoblot analysis with a monoclonal antibody that recognizes both nonmammalian RYR isoforms and a polyclonal antibody specific to the alpha isoform show two key results: (a) two reptilian orders share with mammals the pattern of expressing only the alpha (skeletal) RYR isoform in skeletal muscle; and (b) certain functionally specialized muscles of fish and birds express only the alpha RYR isoforms. While both isoforms are expressed in the body musculature of fish and birds, the alpha isoform is expressed alone in extraocular muscles and swimbladder muscles. The appearance of the alpha RYR isoform alone in the extraocular muscles and a fast-contracting sonic muscle in fish (toadfish swimbladder muscle) provides evidence that this isoform is selectively expressed when rapid contraction is required. The functional and phylogenetic implications of expression of the alpha isoform alone are discussed in the context of the mechanism and evolution of excitation-contraction coupling.
Evaluating Community Collaboration for Sustained Change in Health and Equity: Telling the Story of RADx-UP C2G Pilot Projects
Creators: name: Maras, Shelly
name: Roberts, Rossana
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2023

description: The Community Collaboration Grants program (C2G) — a pilot grant program under the Rapid
Acceleration of Diagnostics-Underserved Populations (RADx-UP) Program — aims to advance
capacity, training, and support for community organizations in underserved communities.
RADx-UP projects utilize either community-based participatory research (CBPR) methods or
community engagement principles to increase COVID-19 testing and pandemic preparedness
among underserved populations. Community engagement, or the process of developing
relationships to collaboratively address and promote health outcomes, is a crucial factor for
fostering health equity and addressing COVID-19 prevention and control measures.

Our evaluation investigates the long-term impacts and lessons learned from projects receiving a
C2G award. We employed a qualitative, narrative analysis to evaluate projects’ successes,
challenges, sustainability, and community impacts. As of September 7, 2023, 69 C2G awards
had been made. Our team conducted 29 interviews with community organizations (i.e. C2G
project awardees) to collect in-depth stories about project outcomes. We analyzed interviews
using a hybrid of deductive and inductive thematic analyses via Dedoose, an online analysis
software. Prior to coding, we tested for interrater reliability and our overall Cohen’s Kappa was
0.75. We then altered the codebook to address discrepancies.

We found that C2G projects improve health equity in underserved communities by tailoring
COVID-19 education and testing interventions to community needs. They do so by partnering
with other community organizations to conduct research and outreach, building and maintaining
trust in communities, and addressing social determinants of health. C2G projects’ stories are
impactful for both program evaluation as well as sharing lessons learned with others conducting
CBPR in the field of public health research.
A TAXONOMY OF PATTERN THROUGH THE ANALYSIS OF NOTTINGHAM LACE
Creators: name: Briggs-Goode, Amanda
name: Buttress, Joy
Publisher: name: FUTURESCAN
Year: 2019
Subjects: subject: 120306 Textile and Fashion Design
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: This research paper was presented at Futurescan: Mapping the Territory, Foresight Centre, University of Liverpool, 17-18 November 2009.

Futurescan: Mapping the Territory
Edited by Sally Wade and Kerry WaltonFebruary 2011ISBN: 978 1 907382 30 7
Additional file 3 of Association between radiographic hand osteoarthritis and bone microarchitecture in a population-based sample
Creators: name: Ma, Canchen
name: Aitken, Dawn
name: Wu, Feitong
name: Squibb, Kathryn
name: Cicuttini, Flavia
name: Jones, Graeme
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Hematology

description: Additional file 3: Supplementary Table 2. Standardized beta-coefficients for the associations of osteophyte scores with site-specific HRpQCT measures (per SD) stratified by 1st CMC, distal and proximal DIP and PIP sites (N=201).