cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Training and Development Practice of Plastic Industry and Its Effect on Employees Performance. (The Case of Geo-synthetics Industrial Works Plc.)
Creators: name: Tsegaye, Deresse
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2017

description: Human resource is being the most important resource from other resources, training and development is very crucial for the success of an organization because it motivates and increases the skill of employees and upgrades the ability of managers to perform their task. The research was conducted at Geosynthetics Industrial Works plc. And the main objective of this study was to asses training and development practice and its effect on employee's performance. Descriptive research design methodology was used. A total of 95 employees were included in this study using simple random sampling technique. Data entered, encode, clean and analyzed using SPSS version20. Eighty employees responded that training and development need assessment was conducted properly and half of them revealed that performance appraisal was used to determine the training and development needs in the organization. The training evaluation significantly associated with employees' performance. Training evaluation has to consider as main training component in order to increase employee performance. Employee performance explained significantly by training evaluation, training need assessment, training design and training implementation. Training practice accepted to enhance employee performance and create standardize job performance. An organization has to allocate enough resource in order to deliver varieties of training and development program. Key Words: Training and development,Employee performance, Human resource management, Geosynthetis industrial works plc.
The role of NHX-type Na+/H+ exchangers in plant development and subcellular protein trafficking in Arabidopsis thaliana
Creators: name: Dragwidge, Jonathan
Publisher: name: La Trobe
Year: 2023

description: Submission note: A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the Department of Animal, Plant and Soil Science, School of Life Sciences, College of Science, Health and Engineering [and] AgriBio, the Centre for Agribiosciences, La Trobe University, Bundoora, Victoria.
Premedicación en cirugía electiva de adultos y niños encuesta de anestesiólogos Universidad de Cartagena, Colombia, 2012
Creators: name: Vargas Torres, Glenda Patricia
Publisher: name: Universidad de Cartagena
Year: 2012
Subjects: Anestésicos
Anestesia
Cirugía en niños
Cirugía

description: Tesis (Especialista en Anestesiología y Reanimación). -- Universidad de Cartagena, Facultad de Medicina. Departamento Quirúrgico, 2012
description: La siguiente investigación tiene como fin Identificar el grupo farmacológico utilizado con mayor frecuencia para premedicación de pacientes adultos y niños en cirugías electivas
Computational simulation and molecular design of novel anti-leishmanial drug
Creators: name: Rajasekaran, Rajalakshmi
Publisher: name: La Trobe
Year: 2023

description: Submission note: Submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the Department of Computer Science and Information Technology, School of Engineering and Mathematical Sciences, College of Science, Health and Engineering, La Trobe University, Bundoora, Victoria.
title: Effekte einer Tocilizumab-Therapie auf die Knochendichte, Marker des Knochenstoffwechsels und Aktivitätsparameter bei TNF-α vortherapierter aktiver rheumatoider Arthritis
Creators: name: Lange, Uwe
name: Neumann, Elena
name: Frommer, Klaus
name: Dischereit, Gabriel
name: Müller-Ladner, Ulf
Publisher: name: German Medical Science GMS Publishing House
Year: 2015
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Ziel der 1-jährigen Prospektivstudie war die Analyse einer Therapie mit Tocilizumab (TOZ), einem anti-IL-6-Rezeptor-Antikörper, auf die Knochendichte, Marker des Knochenstoffwechsels und Aktivitäts-/Funktionsparameter bei TNF-α vortherapierter aktiver rheumatoider[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 43. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 29. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 25. wissenschaftliche Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Naturalness, Vacuum Stability and Leptogenesis in the Minimal Seesaw Model
Creators: name: Bambhaniya, Gulab
name: Dev, P. S. Bhupal
name: Goswami, Srubabati
name: Khan, Subrata
name: Rodejohann, Werner
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The right-handed neutrinos within the type-I seesaw mechanism can induce large radiative corrections to the Higgs mass, and naturalness arguments can then be used to set limits on their mass scale and Yukawa couplings. Driven by minimality, we consider the presence of two degenerate right-handed neutrinos. We compare the limits from naturalness with the ones from the stability of the electroweak vacuum and from lepton flavor violation. Implications from neutrinoless double beta decay are also discussed and renormalization effects for the light neutrino parameters are presented. Adding small perturbations to the degenerate heavy neutrino spectrum allows for successful leptogenesis.
description: 22 pages, 11 figures; minor changes; version to appear in Phys. Rev. D
Infección del tracto urinario en pacientes de 0 a 24 meses de edad de enero de 2008 a diciembre de 2008 en el Hospital Infantil Napoleón Franco Pareja. Cartagena, Colombia
Creators: name: Giraldo Velásquez, Oscar Adrián
Publisher: name: Universidad de Cartagena
Year: 2010
Subjects: Infecciones del tracto urinario
Pediatría - Enfermedades infecciosas
Infecciones -Tratamiento

description: Tesis (Especialista en Pediatría) -- Universidad de Cartagena, Facultad de Medicina. Departamento Pediatría, 2010
description: Siendo la Infección del Tracto Urinario unas de las principales patologías infecciosas en la infancia, causa de múltiples consultas a los servicios de urgencias, responsable de un gran número de prescripciones de terapia antibiótica, con el advenimiento cada vez mayor de la resistencia microbiana a los agentes terapéuticos, a una sintomatología inespecífica en el período de la lactancia, a los daños severos que puede conllevar un diagnóstico inoportuno de la entidad en el funcionamiento renal por las secuelas irreversibles o la formulación antimicrobiana inadecuada para el tratamiento de este tipo de infección y aunado al desconocimiento de la epidemiología local, se hace necesario la elaboración de trabajos de investigación que nos puedan brindar pautas en cuanto el abordaje más apropiado y óptimo para nuestros pacientes.
Fourth order wave equation in Bhabha-Madhavarao spin-$\frac{3}{2}$ theory
Creators: name: Markov, Yu. A.
name: Markova, M. A.
name: Bondarenko, A. I.
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Within the framework of the Bhabha-Madhavarao formalism, a consistent approach to the derivation of a system of the fourth order wave equations for the description of a spin-$\frac{3}{2}$ particle is suggested. For this purpose an additional algebraic object, the so-called $q$-commutator ($q$ is a primitive fourth root of unity) and a new set of matrices $η_μ$, instead of the original matrices $β_μ$ of the Bhabha-Madhavarao algebra, are introduced. It is shown that in terms of the $η_μ$ matrices we have succeeded in reducing a procedure of the construction of fourth root of the fourth order wave operator to a few simple algebraic transformations and to some operation of the passage to the limit $z \rightarrow q$, where $z$ is some (complex) deformation parameter entering into the definition of the $η$-matrices. In addition, a set of the matrices ${\cal P}_{1/2}$ and ${\cal P}_{3/2}^{(\pm)}(q)$ possessing the properties of projectors is introduced. These operators project the matrices $η_μ$ onto the spins 1/2- and 3/2-sectors in the theory under consideration. A corresponding generalization of the obtained results to the case of the interaction with an external electromagnetic field introduced through the minimal coupling scheme is carried out. The application to the problem of construction of the path integral representation in parasuperspace for the propagator of a massive spin-$\frac{3}{2}$ particle in a background gauge field within the Bhabha-Madhavarao approach is discussed.
description: 51 pages, the version published in Int.J.Mod.Phys.A
Bambusa Schreber 1789
Creators: name: Ruiz-Sanchez, Eduardo
name: Clark, Lynn G.
name: Londoño, Ximena
name: Mejía-Saulés, Teresa
name: Rodríguez, Gilberto Cortés
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Poales
Poaceae
Bambusa

description: Bambusa Schreber
Rhizomes pachymorph; culms hollow, 5–20 m tall, 5–15 cm in diameter, erect to apically arching; culm leaf sheaths well developed, pubescent, auricles present, fimbriae present or absent, oral setae absent; culm leaf blades erect, deciduous; branching intravaginal; node with one central bud developing into 1 main central branch bearing several to numerous smaller secondary branches, thorns usually absent, supra- and infranodal bands of short-soft white hairs absent; synflorescences paniculate; pseudospikelets comprising 1 subtending bract, 1 2-keeled broad prophyll, 1 gemmiparous bract, 1–3 glumes, 2 to several florets; lemmas broad, glabrous, paleas 2-keeled; lodicules 3 or 2; stamens 6; fruit a basic caryopsis. Introduced Asiatic genus (Fig. 9A, E).
 1. Culms dark green; culm leaf sheaths abaxially pubescent with spinous-hairy, dark brown hairs; auricles slightly conspicuous; culm leaf blades with the base not rounded, more than 1/2 the width of the sheath apex; branches many, 3 dominant......................................................................................................................................................................................................................... B. oldhamii
 1. Culms bright green or yellow with green stripes; culm leaf sheaths abaxially hispid with stiff, appressed dark brown hairs; auricles tiny and ciliate; culm leaf blades with the base slightly rounded, 1/2 the width of the sheath apex; branches many, 1 dominant.................................................................................................................................................................................................. B. vulgaris
description: Published as part of Ruiz-Sanchez, Eduardo, Clark, Lynn G., Londoño, Ximena, Mejía-Saulés, Teresa & Rodríguez, Gilberto Cortés, 2015, Morphological keys to the genera and species of bamboos (Poaceae: Bambusoideae) of Mexico, pp. 1-24 in Phytotaxa 236 (1) on pages 12-13, DOI: 10.11646/phytotaxa.236.1.1, http://zenodo.org/record/13631250
Hot-Jupiter Core Mass from Roche-lobe Overflow
Creators: name: Ginzburg, Sivan
name: Sari, Re'em
Publisher: name: arXiv
Year: 2016
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The orbits of many observed hot Jupiters are decaying rapidly due to tidal interaction, eventually reaching the Roche limit. We analytically study the ensuing coupled mass loss and orbital evolution during the Roche-lobe overflow and find two possible scenarios. Planets with light cores $M_c\lesssim 6M_\oplus$ (assuming a nominal tidal dissipation factor $Q\sim 10^6$ for the host star) are transformed into Neptune-mass gas planets, orbiting at a separation (relative to the stellar radius) $a/R_\star\approx 3.5$. Planets with heavier cores $M_c\gtrsim 6M_\oplus$ plunge rapidly until they are destroyed at the stellar surface. Remnant gas-Neptunes, which are stable to photo-evaporation, are absent from the observations, despite their unique transit radius ($5-10R_\oplus$). This result suggests that $M_c\gtrsim 6M_\oplus$, providing a useful constraint on the poorly-known core mass that may distinguish between different formation theories of gas giants. Alternatively, if one assumes a prior of $M_c\approx 6 M_\oplus$ from the core-accretion theory, our results suggest that $Q$ does not lie in the range $10^6\lesssim Q\lesssim 10^7$.
description: Matched to published version
The Effect of Training on Employee Performance: The Case of Selected Colleges in Addis Ababa University
Creators: name: Chaka, Wagaye
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2017

description: Employee is a valuable asset of an organization. The survival of the organization depends upon its employee performance. Thus, AAU is investing on training for the employees of its Colleges. This study, therefore, tried to assess the effect of training on employee performance in the case of the selected Colleges namely - College of Humanities, Language Studies, Journalism and Communication; and College of Performing and Visual Arts. In order to get the real picture of the effect of training on employee performance, the research design was causal research design. The total population of the study was 240 and 150 sample respondents were selected by using proportionate stratified and simple random sampling techniques. Cross-sectional survey strategy was conducted to gather data from sample employees. The sources of data were primary and secondary. The primary data were collected via self-administered structured questionnaire and the secondary data were gathered from available relevant published as well as unpublished materials. The questionnaires were distributed to all 150 sample respondents in which 138 of them returned i.e. the response rate was 92%. To present and analyze data, descriptive and inferential statistic analysis was done using Statistical Package for Social Sciences (SPSS) Version 20. Pearson's product moment correlation coefficient was used to assess the relationship between training needs assessment, training design, training delivery, and training evaluation (training dimensions); and employee performance. The findings revealed that training needs assessment; training design; training delivery; and training evaluation have a statistically significant and positive relationship with employee performance. The study was also employed multiple regression analysis to identify the overall effect of training on employee performance. The result showed that 79.7% of variation in the employee performance can be explained by the training dimensions. Therefore, the study concluded that training has strong positive effect on employee performance in the two selected Colleges of AAU.
Synthesis and biological evaluation of 4-Cyano-3-Methylisoquinolines and related isoquinoline analogues against plasmodium falciparum
Creators: name: Kalhor, Robabeh
Publisher: name: La Trobe
Year: 2023

description: Submission note: A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Molecular Sciences, College of Science, Health and Engineering, La Trobe University, Bundoora.

In 2015, according to the World Health Organisation, there were an estimated 212 million cases of malaria and some 429,000 of these people did not survive. In addition to the burden on human health, there is a significant cost to bear globally from malaria. Plasmodium falciparum is the species which causes the most severe malarial disease and is the leading cause of death in Africa. Unfortunately P. falciparum has shown resistance to antimalarial drugs, diminishing their therapeutic efficacy and presenting a major barrier to disease management. This dissertation reports the efficient synthesis of a series of isoquinoline derivatives and the study of their potential anti-malarial activities. Screening of these small molecules in a parasite cellular assay was undertaken on asexual blood stage parasites of P. falciparum 3D7 and chloroquine-resistant W2mef strains using a colorimetric assay. The amount of parasite enzyme lactate dehydrogenase measured is positively correlated with parasite proliferation. In the first part of this project, a series of 1-substituted 3-methyl-4-cyanoisoquinolines were synthesised and derivatised at the 5- and 7-positions. The optimised synthetic route involved preparation of the isocarbostyril precursor followed by chlorination to give an intermediate which was immediately coupled with a variety of amines to produce substituted isoquinoline analogues. Several inhibitors were found to have EC50 values in the low micromolar range. The second part of the project involved the synthesis of cyclised isoquinolines using tin chloride dihydrate and sodium borohydride. A variety of isoquinolines were prepared which were functionalised at the 5-position. Biological evaluation showed submicromo lar EC50 values for the majority of the cyclised compounds. These encouraging results suggest these structures may be candidates suitable for consideration as new therapeutics for the treatment of malaria.
title: Beta-Confident Registry Results Show Long-Term Safety And Efficacy Of Canakinumab in Cryopyrin-Associated Periodic Syndrome (CAPS) Patients
Creators: name: Kümmerle-Deschner, Jasmin
name: Hoffman, Harold M.
name: Hawkins, Philip N.
name: Van Der Poll, Tom
name: Walker, Ulrich A.
name: Speziale, Antonio
name: Tilson, Hugh
Publisher: name: German Medical Science GMS Publishing House
Year: 2015
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: The β-Confident Registry, the largest CAPS cohort documented in a registry, enrolled the last patient in December 2014. Here, we report interim data for the complete cohort of enrolled patients. The objective is to monitor the overall safety of canakinumab (CAN) focusing on SAEs [for full text, please go to the a.m. URL]
description: 43. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 29. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 25. wissenschaftliche Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Connection formulas for the Ablowitz-Segur solutions of the inhomogeneous Painlevé II equation
Creators: name: Dai, Dan
name: Hu, Weiying
Publisher: name: arXiv
Year: 2016
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: 41A60, 33C45

description: We consider the second Painlevé equation $$ u"(x)=2u^3(x)+xu(x)-α, $$ where $α$ is a nonzero constant. Using the Deift-Zhou nonlinear steepest descent method for Riemann-Hilbert problems, we rigorously prove the asymptotics as $x \to \pm \infty$ for both the real and purely imaginary Ablowitz-Segur solutions, as well as the corresponding connection formulas. We also show that the real Ablowitz-Segur solutions have no real poles when $α\in (-1/2, 1/2)$.
description: minor revision, 32 pages, 8 figures
Seifert fibrations of lens spaces
Creators: name: Geiges, Hansjörg
name: Lange, Christian
Publisher: name: arXiv
Year: 2016
Subjects: subject: Geometric Topology (math.GT)
subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics
subject: 57M50, 55R65, 57M10, 57M60

description: We classify the Seifert fibrations of any given lens space L(p,q). We give an algorithmic construction of a Seifert fibration of L(p,q) over the base orbifold S^2(m,n) with the coprime parts of m and n arbitrarily prescribed. This algorithm produces all possible Seifert fibrations, and the equivalences between the resulting Seifert fibrations are described completely. Also, we show that all Seifert fibrations are equivalent to certain standard models.
description: 22 pages, 1 figure; v2: minor changes to the exposition
Caracterización de la cultura organizacional en la Universidad de Cartagena,Claustro de San Agustín,municipio de Cartagena, Departamento de Bolívar y su influencia en el servicio al cliente interno
Creators: name: Torres Castro, Diana Paola
name: Medina Rodríguez, Claudia María
Publisher: name: Universidad de Cartagena
Year: 2002
Subjects: Cultura Organizacional
Servicio al cliente

description: Tesis (Administrador de Empresas). -- Universidad de Cartagena. Facultad de Ciencias Económicas. Programa de Administración de Empresas, 2002
description: El presente estudio tiene por objeto caracterizar la cultura organizacional de la Universidad de Cartagena, Claustro de San Agustín y determinar su influencia en la prestación del servicio a los clientes internos.
Development of protocols for environmental impact studies using causal modelling, with special reference to wastewater discharges to freshwater systems
Creators: name: Hatami, Rezvan
Publisher: name: La Trobe
Year: 2023

description: Submission note: A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the Department of Ecology, Environment and Evolution, La Trobe University, Bundoora.

As the population of the world is increasing and water resources have become scarce, an appropriate assessment of freshwater systems has become increasingly important. A major challenge to assessing the impacts of human activities is accounting for natural spatiotemporal variation. Current freshwater assessments are unable to solve spatiotemporal confounding through study designs or statistical analyses. Study designs in observational studies fail to consider the period-by-location interaction in the absence of an impact and using statistical analysis alone is inadequate. In the present study, the problem of spatiotemporal confounding was addressed using causal modelling based on spatiotemporal data to infer causal effects of wastewater on biotic ecosystems. A combination of statistical analysis and the theory of causation was used to address confounding bias and to predict the effect of future interventions. Benthic macroinvertebrate and environmental variable data were collected from eight sites upstream and downstream of a wastewater treatment plant discharge point along 8km of waterway at five times of sampling times over 1.5 years. The composite hypotheses based on the theoretical relationships among these variables were summarised in a causal diagram. Model building and testing was conducted using Structural Equation Modelling (SEM). Distance-based redundancy analysis (dbRDA) was used for model building and hypothesis testing. The results indicated that the causal effects of effluent on macroinvertebrate communities could be inferred using causal modelling. The macroinvertebrate communities responded to water quality degradation with a clear shift in community composition after the discharge point that varied seasonally. Chlorophyll a, TOC, zinc, conductivity, temperature and its interaction with conductivity were important determinants of the macroinvertebrates. Causal models also explained the spatiotemporal variations in environmental variables. The consistency of data with the structure of the causal diagram was confirmed with global Fisher’s C-test. The final causal models were used to predict the effect that manipulating the values of observed discharge would have on abiotic variables; demonstrating how causal modelling can be used for developing protocols for environmental impact studies.
title: Do Changes in Clinical Practice over Time in Europe and Canada Have an Impact on Baseline Characteristics of Patients Initiating Intravenous Abatacept in the ACTION Study?
Creators: name: Nüßlein, Hubert G.
name: Alten, Rieke H.-E.
name: Galeazzi, M
name: Lorenz, Hanns-Martin
name: Cantagrel, A.
name: Chartier, M
name: Poncet, C
name: Rauch, C
name: Le Bars, Manuela
Publisher: name: German Medical Science GMS Publishing House
Year: 2015
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: IV abatacept has been available in Europe for use with MTX in adults with moderate-to-severe RA failing ≥1 anti-TNF since 2007 and approved for first-line use in patients failing conventional synthetic (cs)DMARDs since 2010. In Canada, IV abatacept has been available as mono- or[for full text, please go to the a.m. URL]
description: 43. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 29. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 25. wissenschaftliche Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Understanding wellbeing among middle aged immigrant Malay women in Melbourne
Creators: name: Ab Razak, Asrenee
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Aging as an immigrant is not easy. While migration has been shown to pose a risk to mental health among recently arrived immigrants, the acculturation process that develops over time does not necessarily protect their psychological wellbeing in later life. This is a great concern for Australia as the majority of its population is immigrant, with an increasing number from cultural and linguistic backgrounds distinct from the historically dominant population. Malays constitute a small fraction of the Australian population, yet the size of this community is increasing and therefore there is a value to study their aging. This ethnographic research examines the interaction between cultural and social environments in midlife, among immigrant Malay women living in Melbourne. This research was undertaken using a social constructionist approach, and in the course of this study, I attempt to understand women’s midlife journey and how this shapes their everyday lives as immigrants, using Bourdieu’s theory of habitus (1990), and theories of social capital particularly as explained by Putnam (1995), Coleman (1990) and Bourdieu (1986). Ethnographic data were collected using multiple methods from July 2010 to December 2012 in Melbourne. Thirty three women were recruited through snowball sampling, with 18 women participating in in-depth interviews and 15 women participating in three focus group discussions. Five key informants were interviewed separately. The data were analyzed using thematic analysis. My findings suggested that the journey of midlife changes immigrant Malay women’s perceptions of their priorities in life, and this in turn influences ideas of how to life, their daily practices, and hence their psychological wellbeing. How they navigate their lives is reflected in their habitus and influenced by the availability and accessibility of social capital; this in turn influenced their psychological wellbeing. The concept of psychological wellbeing as understood by the women is grounded in religious doctrines that shaped their dispositions. Acculturation to Australian society and local norms, values and understandings of wellbeing, and women’s own responses to their aging and to bodily changes, further contributed to how they understood wellbeing. Women’s subjectivity was constituted by practices that are informed by and sustain religious norms. Changes in dress, and their involvement in a particular religious community, informed the embodied behaviours that transformed women’s identity and, as they explained, “shaped their inner souls,” therefore, also their wellbeing. Women’s innovative and creative acquisition of new dispositions defined who they were as Malay-Muslim immigrants in Australia.
PARP1pred: a web server for screening the bioactivity of inhibitors against DNA repair enzyme PARP-1
Creators: name: Lerksuthirat, Tassanee
name: Chitphuk, Sermsiri
name: Stitchantrakul, Wasana
name: Dejsuphong, Donniphat
name: Malik, Aijaz Ahmad
name: Nantasenamat, Chanin
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2023
Subjects: PARP-1
DNA repair
machine learning
QSAR
webserver
cheminformatics

description: Cancer is the leading cause of death worldwide, resulting in the mortality of more than 10 million people in 2020, according to Global Cancer Statistics 2020. A potential cancer therapy involves targeting the DNA repair process by inhibiting PARP-1. In this study, classification models were constructed using a non-redundant set of 2018 PARP-1 inhibitors. Briefly, compounds were described by 12 fingerprint types and built using the random forest algorithm concomitant with various sampling approaches. Results indicated that PubChem with an oversampling approach yielded the best performance, with a Matthews correlation coefficient > 0.7 while also affording interpretable molecular features. Moreover, feature importance, as determined from the Gini index, revealed that the aromatic/cyclic/heterocyclic moiety, nitrogen-containing fingerprints, and the ether/aldehyde/alcohol moiety were important for PARP-1 inhibition. Finally, our predictive model was deployed as a web application called PARP1pred and is publicly available at https://parp1pred.streamlitapp.com, allowing users to predict the biological activity of query compounds using their SMILES notation as the input. It is anticipated that the model described herein will aid in the discovery of effective PARP-1 inhibitors.
description: EXCLI Journal; 22:Doc84; ISSN 1611-2156
Beacon of hope: Human Rights and decolonisation in Botswana, 1960-80
Creators: name: Kirby, James Christian
Publisher: name: La Trobe
Year: 2023

description: Submission note: A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the Department of Archaeology and History, College of Arts, Social Sciences, and Commerce, La Trobe University, Bundoora.

This thesis is a history of human rights and decolonisation in Botswana from 1960 to 1980. It argues that Botswana became a ‘success story’ for human rights because the post-colonial leadership interpreted these principles as conducive to the vital interests of the state. The project joins a growing list of case studies, at the vanguard of the scholarship, that unmasks the contribution of small non-Western states to the international history of human rights. At independence in 1966, the country was economically underdeveloped and geographically vulnerable, surrounded by white minority regimes like apartheid South Africa and Rhodesia. To become a viable and autonomous state, Botswana used human rights idealism to attract assistance from North America and Western Europe. The investigation traces the development of President Seretse Khama’s concept of ‘non-racial democracy’, a philosophy based on international standards of human rights. By enshrining political liberties and individual protections in Botswana, he offered a model for how these principles could be applied in Southern Africa, thereby undermining the legitimacy of neighbouring white minority regimes. Western nations, especially the United States (US), gave substantial amounts of aid to Botswana as a reward for its efforts. Not restricted to a liberal-democratic version of human rights, Botswana earned respect in independent Africa for its advocacy of collective liberation in the region. This challenges the view, held by many scholars, that the movements for individual human rights and national self-determination were mutually exclusive. With the use of original archival material from Botswana, the United Kingdom, and the US, this thesis also offers a new political history of the country’s lead up to independence and its external affairs by showing the important role of human rights ideas and debates. Botswana’s acclaimed ‘success’ in human rights was an outstanding example of image-building in circumstances where survival was tied to international visibility.
title: Ergebnisse zu den Patient Reported Outcomes (PRO) in MIRAI: Einer Studie zur sequentiellen Therapie mit Tocilizumab (TCZ) und, im Falle eines anfänglich unzureichenden Ansprechens auf TCZ, einer Anschlussbehandlung mit Rituximab (RTX)
Creators: name: Iking-Konert, Christof
name: Burmester, Gerd-Rüdiger
name: Dörner, Thomas
name: Schulze-Koops, Hendrik
name: Rubbert-Roth, Andrea
name: Engel, Andreas
name: Peters, Marvin A.
name: Tony, Hans-Peter
Publisher: name: German Medical Science GMS Publishing House
Year: 2015
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: In der MIRAI-Studie (NCT01332994) wurde das frühe und das späte Ansprechen auf den IL-6R-Inibitor TCZ in einer homogenen Population Biologika-naïver Patienten mit mittelschwerer/ schwerer aktiver RA untersucht, die unzureichend auf konventionelle DMARDs ansprachen; Patienten[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 43. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 29. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 25. wissenschaftliche Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Vacuum radiation from massive scalar field
Creators: name: Cao, Yu-Song
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The vacuum radiation of a massive scalar field is studied by means of a single moving mirror. The field equation with an arbitrary-shaped mirror moving in $(d+1)$ dimensions is given perturbatively in the non-relativistic limit. Explicit results are obtained for a flat mirror moving in $(1+1)$ dimensions and $(3+1)$ dimensions. The vacuum radiation power and vacuum friction force on the mirror are given in $(1+1)$ dimensions. The intrinsic mass of the field is found to suppress the vacuum radiation. In $(3+1)$ dimensions, the modification of the frequency spectra and angular spectra of emitted particles due to the intrinsic mass are obtained. In the limit of $m\to 0$, we recover the results of the massless field.
description: 12 pages, 3 figures
Creación de un magicbook como apoyo de aprendizaje en la asignatura procesos de alimentos II del programa de Ingeniería de Alimentos
Creators: name: Coronel Cardona, Carlos G.
Publisher: name: Universidad de Cartagena
Year: 2016
Subjects: Realidad virtual
Realidad virtual - Enseñanza
Aprendizaje por máquina

description: Tesis (Ingeniero de Sistemas).--Universidad de Cartagena. Facultad de Ciencias E Ingenierías. Programa de Ingeniería de Sistemas, 2016
description: El proyecto titulado Creación de un magicbook como apoyo de aprendizaje en la asignatura procesos de alimentos II del Programa de Ingeniería de Alimentos se realizó con el objetivo de desarrollar una aplicación basada en realidad aumentada como apoyo a la enseñanza en la temática de la tecnología de carnes. A través de esta se le permitirá tanto a docentes como estudiantes del programa de ingeniería de alimentos de la Universidad de Cartagena contar con nuevas y didácticas herramientas tecnológicas con las que se espera hacer más ameno el proceso de aprendizaje.
Impact of Talent Management Practices on Employees' Turnover Intention in Ethiopian Management Institute
Creators: name: Kidanie, Andualem
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2017

description: The purpose of this study was to investigate the impact of talent management practice on employees' turnover intention in Ethiopian Management Institute. The study used quantitative research method and employed explanatory survey design to objectively answer the research questions. For achieving the study objective, 151 sample respondents were selected through simple random sampling technique. Accordingly, data were collected through self administered questionnaire from sample respondents. Out of 151 respondents, workable data were obtained from 146 respondents. Those data, then, analyzed through descriptive and inferential statistics, and also through independent samples T test. The finding of descriptive analysis revealed that the mean score for overall talent management practice is slightly below the average. From the seven components of talent management practices, strategy and talent engagement are the only items that fall slightly above the midpoint, whereas, the remaining facets fall slightly below the average. Talent retention is the least rated component of talent management, which scored far less from the midpoint. The correlation analysis result showed that there is a significant negative relationship exists between talent management practices and employees' turnover intention. Moreover, the regression analysis evidenced that talent management practice is predictor of employees' turnover intention. It is also noted that talent review process and talent deployment are found unique contributor for employees turnover intention. The study exhibited through independent samples T test that employees at core staff (consultants) evaluate TM practice lesser than the evaluation of support staff and they (consultants) also have higher turnover intention than employees at support staff. Furthermore, on the basis of the research findings, appropriate recommendations along with implications for further studies have been forwarded
Leveraging Union of Subspace Structure to Improve Constrained Clustering
Creators: name: Lipor, John
name: Balzano, Laura
Publisher: name: arXiv
Year: 2016
Subjects: subject: Machine Learning (cs.LG)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Many clustering problems in computer vision and other contexts are also classification problems, where each cluster shares a meaningful label. Subspace clustering algorithms in particular are often applied to problems that fit this description, for example with face images or handwritten digits. While it is straightforward to request human input on these datasets, our goal is to reduce this input as much as possible. We present a pairwise-constrained clustering algorithm that actively selects queries based on the union-of-subspaces model. The central step of the algorithm is in querying points of minimum margin between estimated subspaces; analogous to classifier margin, these lie near the decision boundary. We prove that points lying near the intersection of subspaces are points with low margin. Our procedure can be used after any subspace clustering algorithm that outputs an affinity matrix. We demonstrate on several datasets that our algorithm drives the clustering error down considerably faster than the state-of-the-art active query algorithms on datasets with subspace structure and is competitive on other datasets.
description: 11 pages, 8 figures
Investigation of the molecular mechanism of action of surface acting peptides on biomimetic membranes
Creators: name: Mahdi Shahmiri
Publisher: name: La Trobe
Year: 2023

description: Submission note: This thesis is submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the Department of Chemistry and Physics, School of Molecular Sciences, College of Science, Health and Engineering, La Trobe University, Melbourne.
Estudio de estrategias innovadoras en servicio de restauración. Caso restaurante Erre de Ramón Freixa en la ciudad de Cartagena
Creators: name: Martínez Salgado, Juan Camilo
name: Pérez Julio, Carlos Andrés
Publisher: name: Universidad de Cartagena
Year: 2015
Subjects: Planificación estratégica
Gerencia estratégica
Estrategias innovadoras - Restaurante Erre de Ramón Freixa - Cartagena, (Bolívar)

description: Tesis (Administrador de Empresas).--Universidad de Cartagena. Facultad de Ciencias Económicas. Programa de Administración de Empresas, 2015
description: En este trabajo de investigación se observa la necesidad de innovar como base importante dentro del proceso administrativo para toda empresa, para ello se busca documentar el caso en el Restaurante erre de RAMÓN FREIXA en la ciudad de Cartagena de Indias, Colombia, como uno de los restaurantes exitosos por su innovación en el servicio prestado a sus clientes
Merostachys Sprengel 1825
Creators: name: Ruiz-Sanchez, Eduardo
name: Clark, Lynn G.
name: Londoño, Ximena
name: Mejía-Saulés, Teresa
name: Rodríguez, Gilberto Cortés
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Poales
Poaceae
Merostachys

description: Merostachys Sprengel
Rhizomes pachymorph; culms hollow with thin walls, 3–6 m tall, 1.5–2 cm in diameter, scandent; internodes green with purple macules internodes green with purple spots, appressed tricomes below the nodes, internodes papillose-scabrose; culm leaf sheaths well developed, deciduous with fimbriae; culm leaf blade reflexed; branching intravaginal; node with one bud developing 25–30 branches in distinctly fan-shaped (apsidate) arrangement; foliage leaves pseudopetiolate and fimbriate; synflorescences racemose, Comb-like; fruit a nucoid caryopsis.”
 1 species in Mexico: Merostachys sp. Endemic to Mexico; Chiapas; 1900–2100 m (Fig. 2E–F).
description: Published as part of Ruiz-Sanchez, Eduardo, Clark, Lynn G., Londoño, Ximena, Mejía-Saulés, Teresa & Rodríguez, Gilberto Cortés, 2015, Morphological keys to the genera and species of bamboos (Poaceae: Bambusoideae) of Mexico, pp. 1-24 in Phytotaxa 236 (1) on page 17, DOI: 10.11646/phytotaxa.236.1.1, http://zenodo.org/record/13631250
title: Prediction of Remission and Low Disease Activity in DMARD-Refractory Patients with RA Treated with Golimumab
Creators: name: Vastesaeger, Nathan
name: Durez, Patrick
name: Dasgupta, Bhaskar
name: Combe, Bernard
name: Schulze-Koops, Hendrik
name: Louw, Ingrid
name: Wollenhaupt, Jürgen
name: Zerbini, Cristiano
name: Beaulieu, André
name: Pavelka, Karel
name: Lazaro, Maria
name: Garcia Kutzbach, Abraham
name: Moots, Robert J.
name: Amital, Howard
name: Huyck, Susan
name: Fu, B.
name: Govoni, Marinella
Publisher: name: German Medical Science GMS Publishing House
Year: 2015
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: EULAR recommendations for RA therapy suggest addition of a biologic only if poor prognostic factors such as high disease activity are present. However, low baseline disease activity is associated with better biologic treatment outcomes. Objective: To develop a tool to predict remission/low[for full text, please go to the a.m. URL]
description: 43. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 29. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 25. wissenschaftliche Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
title: Lebensqualität von Patienten mit RA, PsA und AS in einer nicht-interventionellen klinischen Erhebung unter Golimumab – GO-NICE 3. Interimsanalyse
Creators: name: Thomas, Matthias
name: Krüger, Klaus
name: Aries, Peer
name: Bohl-Bühler, Martin
name: Brandt-Jürgens, Jan
name: Rickert, Verena
Publisher: name: German Medical Science GMS Publishing House
Year: 2015
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: In einer nicht-interventionellen, prospektiven, multizentrischen Studie (GO-NICE-Studie) sollen neben der Wirksamkeit und Sicherheit der subkutanen Therapie mit Golimumab (GLM) 50 mg Angaben zur Lebensqualität unter Praxisbedingungen in Deutschland erhoben werden. Methoden: Es wurden[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 43. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 29. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 25. wissenschaftliche Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Witness for initial correlations among environments
Creators: name: Tabesh, F. T.
name: Salimi, S.
name: Khorashad, A. S.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: A quantum system inevitably interacts with its surroundings. In general, one does not have detailed information on an environment. Identifying the environmental features can help us to control the environment and its effects on the dynamics of an open system. Here, we consider a tripartite system and introduce a witness for the initial correlations among environments by means of the concept of the trace distance. Due to the existence of the initial environmental correlations, a tight upper bound is obtained for the growth of the trace distance of open quantum system states. Therefore, the initial correlations among the environments subject to particular conditions can be detected by measurements on the open system.
description: 11 pages, 7 figures
Olmeca Soderstrom 1982
Creators: name: Ruiz-Sanchez, Eduardo
name: Clark, Lynn G.
name: Londoño, Ximena
name: Mejía-Saulés, Teresa
name: Rodríguez, Gilberto Cortés
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Poales
Poaceae
Olmeca

description: Olmeca Soderstr.
Rhizomes pachymorph with culm necks short to elongated; culms hollow, erect, scandent and clambering, culm leaf sheaths well developed, auricles present or absent, fimbriae present, oral setae present, culm leaf blades erect or reflexed, deciduous; branching intravaginal; nodes with one primary bud, developing into 1 branch per node; synflorescences paniculate; spikelets linear-lanceolate; glumes 2, glabrous, awned or awnless; 2–12 florets; lemmas awned or mucronate, glabrous or hispid at the apex; lodicules 3, stamens 3; stigmas 2–3; fruit a basic or bacoid (fleshy) caryopsis. (Fig. 6A–F).
1. Rhizome necks 300–900 cm long; fruit a bacoid caryopsis; in tropical rain forests at low elevations from 0– 900 m......................2
1. Rhizome necks 4–30 cm long; fruit a basic caryopsis; in cloud forests at middle elevations, from 1500–2400 m...........................3
 2. Culms erect to apically arched, culm diameter 4.5–5 cm; culm leaf blades erect; rhizome necks up to 3 m long........ Olmeca recta Endemic to Mexico; Chiapas, Veracruz; 0– 900 m.
 2. Culms scandent, culm diameter ca. 2 cm; culm leaf blades reflexed; rhizome necks to 9 m long..................................... Ol. reflexa Endemic to Mexico; Chiapas, Oaxaca, Veracruz; 100– 900 m.
 3. Culms erect and arched for the upper third; culm diameter 1–2 cm; foliage leaf blades adaxially green........................ Ol. clarkiae Mexico and Honduras; Chiapas; 1600–1900 m.
3. Culms scandent and decumbent; culm diameter 0.5–1.0 cm; foliage leaf blades adaxially glaucous...............................................4
 4. Culms 5–6 m long; foliage leaves 4–6 per complement, the blades 18.5–26.5 cm long and 0.7–1.0 cm wide; foliage leaf oral setae 5–10 mm long and 0.2 mm wide.......................................................................................................................................... Ol. fulgor Endemic to Mexico; Oaxaca, Veracruz; 1600–2400 m.
 4. Culms 6.5–8.0 m long; foliage leaves 9–13 per complement, the blades 20–30 cm long and 1.5–2.5 cm wide; foliage leaf oral setae 12–22 mm long and 0.5–1.0 mm wide...................................................................................................................... Ol. zapotecorum Endemic to Mexico; Oaxaca (Cerro Chayotepec); 1470–1500 m.
description: Published as part of Ruiz-Sanchez, Eduardo, Clark, Lynn G., Londoño, Ximena, Mejía-Saulés, Teresa & Rodríguez, Gilberto Cortés, 2015, Morphological keys to the genera and species of bamboos (Poaceae: Bambusoideae) of Mexico, pp. 1-24 in Phytotaxa 236 (1) on pages 17-18, DOI: 10.11646/phytotaxa.236.1.1, http://zenodo.org/record/13631250