cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Project VERA - Replication
Creators: name: Luoma, Jason
name: Tittler, Meredith V.
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Social and Behavioral Sciences
subject: White racial affect; White guilt; White shame

description: In a previous study (Tittler et al., under review), we assessed the convergent, predictive, and incremental validity of the White Racial Affect Scale (WRAS; Grzanka et al., 2020) using a video stimulus meant to elicit the state version of the emotions (White guilt, shame, and negation/defensiveness) measured by the WRAS (WRAS, Grzanka et al., 2020). To assess convergent and divergent validity we looked at the correlations between the WRAS factors, trait guilt and shame, state White guilt, shame, defensiveness, and empathy, attitudes about affirmative action, and a desire to sign up for a study on racial dialogues. We investigated predictive validity of the WRAS by comparing the strength of the correlations between the WRAS factors and other outcome measures to assess whether the relative strength of the correlations aligned with theoretical predictions. Finally, we assessed incremental validity by assessing whether White guilt and White shame predicted state reactions to the video stimulus over and above trait guilt and trait shame. We also explored whether guilt and shame in reaction to the video could be separated into two factors at the state level. The purpose of the current study is to explore whether these results replicate in a White, non-Hispanic college student population at a PWI in the deep south of the United States. The original study was conducted on an adult, non-Hispanic, White population collected using an online data collection service. In this study, we will also address some of the limitations of the first study by omitting the behavioral proxy item that asked participants whether they would sign-up for future studies on racial dialogue, given the lack of any significant findings from this item and similar items across several studies (e.g., Tittler & Wade, 2019; Tittler et al., under review). To capture behavioral intentions, we will instead use the validated Social Justice Behavioral Intentions Scale (Torres-Harding et al., 2012). We have also added a scale to measure attitudes towards reparations, given the more significant salience reparations has in the current U.S. culture compared to affirmative action. We have retained the scale measuring attitudes towards affirmative action for the purpose of comparing results across the two studies.
Rapid Syphilis Testing Uptake for Female Sex Workers at Sex Venues in Southern China: Implications for Expanding Syphilis Screening
Creators: name: Peeling, Rosanna W.
name: Wei, Wan-Hui
name: Shen, Crystal
name: Liu, Guo-Gu
name: Zhu, Zheng-Jun
name: Chen, Xiang-Sheng
name: Huang, Shui-Jie
name: Tucker, Joseph D.
name: Wang, Hong-Chun
name: Mabey, David C.
name: Yin, Yue-Ping
name: Li, Jing
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Accessibility of syphilis testing services is critical in syphilis control programs for female sex workers (FSWs), but few FSWs attend public STI clinics or other testing sites. Introduction of free rapid syphilis testing (RST) into outreach programs for FSWs will help improve test uptake.
Survey # 71
Creators: name: Institut Für Demoskopie Allensbach
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Health (2); liability (5); satisfaction with Chancellor Adenauer’s policies (1); relations between West and East Germany (5); German participation in Western European defense pact (1); fragrance brands (2); clocks and watches (5); coffee brands (2); soup product brands (8); use of lie detectors (2); radio (2); political knowledge (4); mopeds (4); toothbrushes (14); skin care products (26).
RELIABILITY ANALYSIS OF AN ANTI-DRONE SYSTEM BY CONSIDERING RANDOM ENVIRONMENTAL FACTORS
Creators: name: Dharmaraja Selvamuthua
name: Badiyasara, Harshita
name: Smrati Tripathia
name: Kalitab, Priyanka
name: Rajc, Raina
Publisher: name: Reliability: Theory & Applications
Year: 2024
Subjects: Reliability Block Diagram
Laser Source Subsystem
Weibull Distribution
Mean Time to Failure (MTTF)
Rayleigh Distribution
Exponential Distribution
Environmental Factors

description: In today’s security landscape, the proliferation of unauthorized drones in restricted airspace has emerged as a significant threat. These drones pose various risks, from potential surveillance and espionage to more sinister possibilities such as physical attacks. Consequently, the development of effective anti-drone laser systems has become increasingly vital. Our study focuses on three main objectives: modeling internal reliability, identifying critical components, and studying the factors affecting the reliability of anti-drone systems. We aim to enhance the overall performance and effectiveness of anti-drone laser systems by analyzing the reliability of critical components and understanding how system parameters influence system reliability. To this end, reliability block diagram (RBD) methodology has been employed to compute the reliability of the laser subsystem in the anti-drone system. Additionally, we conduct a comprehensive review of component-wise reliability to identify vulnerable points within the system, thus enabling targeted improvements and optimizations. To capture the realistic scenario of system failure behavior, different distributions have been used to compute the reliability of the system, ensuring a thorough understanding of its operational reliability in diverse conditions. Finally, the energy values and probability of hitting are obtained for the anti-drone laser system to effectively mitigate environmental challenges.
Survey # 72
Creators: name: Institut Für Demoskopie Allensbach
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Hopes and fears (1); personal situation (1); consumption patterns (1); tax reform (3); satisfaction with Finance Minister Fritz Schäffer (1); Saar region (2); radio (3); magazines (4); satisfaction with Chancellor Adenauer’s policies (1); political knowledge (2); attitudes toward government ministries (1); relations between West and East Germany (2); European integration (2); soup product brands (8); seasoning brands (1); smoking habits (11); cigarette brands (8); magazines (1).
Resting-State Multi-Spectrum Functional Connectivity Networks for Identification of MCI Patients
Creators: name: Denny, Kevin
name: Yap, Pew-Thian
name: Potter, Guy G.
name: Shen, Dinggang
name: Welsh-Bohmer, Kathleen A.
name: Wang, Lihong
name: Wee, Chong-Yaw
name: Browndyke, Jeffrey N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: In this paper, a high-dimensional pattern classification framework, based on functional associations between brain regions during resting-state, is proposed to accurately identify MCI individuals from subjects who experience normal aging. The proposed technique employs multi-spectrum networks to characterize the complex yet subtle blood oxygenation level dependent (BOLD) signal changes caused by pathological attacks. The utilization of multi-spectrum networks in identifying MCI individuals is motivated by the inherent frequency-specific properties of BOLD spectrum. It is believed that frequency specific information extracted from different spectra may delineate the complex yet subtle variations of BOLD signals more effectively. In the proposed technique, regional mean time series of each region-of-interest (ROI) is band-pass filtered ( Hz) before it is decomposed into five frequency sub-bands. Five connectivity networks are constructed, one from each frequency sub-band. Clustering coefficient of each ROI in relation to the other ROIs are extracted as features for classification. Classification accuracy was evaluated via leave-one-out cross-validation to ensure generalization of performance. The classification accuracy obtained by this approach is 86.5%, which is an increase of at least 18.9% from the conventional full-spectrum methods. A cross-validation estimation of the generalization performance shows an area of 0.863 under the receiver operating characteristic (ROC) curve, indicating good diagnostic power. It was also found that, based on the selected features, portions of the prefrontal cortex, orbitofrontal cortex, temporal lobe, and parietal lobe regions provided the most discriminant information for classification, in line with results reported in previous studies. Analysis on individual frequency sub-bands demonstrated that different sub-bands contribute differently to classification, providing extra evidence regarding frequency-specific distribution of BOLD signals. Our MCI classification framework, which allows accurate early detection of functional brain abnormalities, makes an important positive contribution to the treatment management of potential AD patients.
$η$ Carinae Baby Homunculus Uncovered by ALMA
Creators: name: Abraham, Zulema
name: Falceta-Gonçalves, Diego
name: Beaklini, Pedro P. B.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We report observations of $η$ Carinae obtained with ALMA in the continuum of 100, 230, 280 and 660 GHz in 2012 November, with a resolution that varied from 2.88" to 0.45" for the lower and higher frequencies respectively. The source is not resolved, even at the highest frequency; its spectrum is characteristic of thermal bremsstrahlung of a compact source, but different from the spectrum of optically thin wind. The recombination lines H42$α$, He42$α$, H40$α$, He40$α$, H50$β$, H28$α$, He28$α$, H21$α$ and He21$α$ were also detected and their intensities reveal non local thermodynamic equilibrium (NLTE) effects. We found that the line profiles could only be fit by an expanding shell of dense and ionized gas, which produces a slow shock in the surroundings of $η$ Carinae. Combined with fittings to the continuum, we were able to constrain the shell size, radius, density, temperature and velocity. The detection of the He recombination lines is compatible with the high temperature gas and requires a high energy ionizing photon flux, which must be provided by the companion star. The mass loss rate and wind velocity, necessary to explain the formation of the shell, are compatible with a LBV eruption. The position, velocity and physical parameters of the shell coincide with those of the Weigelt blobs. The dynamics found for the expanding shell corresponds to matter ejected by $η$ Carinae in 1941, in an event similar to that which formed the Little Homunculus ; for that reason we called the new ejecta the "Baby Homunculus".
description: 15 pages, 10 figures, accepted, Astrophysical Journal
Quantum automorphism groups of finite quantum groups are classical
Creators: name: Kasprzak, Paweł
name: Sołtan, Piotr M.
name: Woronowicz, Stanisław L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Operator Algebras (math.OA)
subject: Quantum Algebra (math.QA)
subject: FOS: Mathematics
subject: 46L89, 16T99 (Primary), 20G42, 81R60 (Secondary)

description: In a recent paper of Bhowmick, Skalski and Sołtan the notion of a quantum group of automorphisms of a finite quantum group was introduced and, for a given finite quantum group G, existence of the universal quantum group acting on G by automorphisms was proved. We show that this universal quantum group is in fact a classical group. The key ingredient of the proof is the use of multiplicative unitary operators, and we include a thorough discussion of this notion in the context of finite quantum groups.
description: Minor typos fixed, reference list updated
Survey # 73
Creators: name: Institut Für Demoskopie Allensbach
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Fear of new war (1); US Foreign Minister (2); Indochina war (4); news consumption (3); attitudes toward politicians (14); satisfaction with Chancellor Adenauer’s policies (2); political knowledge (5); German flag (2); attitudes toward political parties (3); freedom of speech (1); personal situation (1); attitudes toward entrepreneurs (1); class struggle (1); laundry detergent brands (7); soup product brands (13); expensive cars (1); hair product brands (18).
Science PhD Career Preferences: Levels, Changes, and Advisor Encouragement
Creators: name: Roach, Michael
name: Sauermann, Henry
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Even though academic research is often viewed as the preferred career path for PhD trained scientists, most U.S. graduates enter careers in industry, government, or “alternative careers.” There has been a growing concern that these career patterns reflect fundamental imbalances between the supply of scientists seeking academic positions and the availability of such positions. However, while government statistics provide insights into realized career transitions, there is little systematic data on scientists' career preferences and thus on the degree to which there is a mismatch between observed career paths and scientists' preferences. Moreover, we lack systematic evidence whether career preferences adjust over the course of the PhD training and to what extent advisors exacerbate imbalances by encouraging their students to pursue academic positions. Based on a national survey of PhD students at tier-one U.S. institutions, we provide insights into the career preferences of junior scientists across the life sciences, physics, and chemistry. We also show that the attractiveness of academic careers decreases significantly over the course of the PhD program, despite the fact that advisors strongly encourage academic careers over non-academic careers. Our data provide an empirical basis for common concerns regarding labor market imbalances. Our results also suggest the need for mechanisms that provide PhD applicants with information that allows them to carefully weigh the costs and benefits of pursuing a PhD, as well as for mechanisms that complement the job market advice advisors give to their current students.
Degree of reductivity of a modular representation
Creators: name: Kohls, Martin
name: Sezer, Müfit
Publisher: name: arXiv
Year: 2014
Subjects: subject: Commutative Algebra (math.AC)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics
subject: 13A50

description: For a finite dimensional representation $V$ of a group $G$ over a field $F$, the degree of reductivity $δ(G,V)$ is the smallest degree $d$ such that every nonzero fixed point $v\in V^{G}\setminus\{0\}$ can be separated from zero by a homogeneous invariant of degree at most $d$. We compute $δ(G,V)$ explicitly for several classes of modular groups and representations. We also demonstrate that the maximal size of a cyclic subgroup is a sharp lower bound for this number in the case of modular abelian $p$-groups.
description: 10 pages
RELIABILITY ESTIMATION OF STRESS-STRENGTH MODEL USING FUZZY DISTORTION FUNCTION UNDER UNCERTAINTY IN ENVIRONMENTAL FACTORS
Creators: name: K. Sruthi
name:  M. Kumar
Publisher: name: Reliability: Theory & Applications
Year: 2024
Subjects: Reliability
Fuzzy reliability
Distortion function
Fuzzy triangular number

description: In the reliability estimation of stress-strength models, external factors such as temperature, humidity, etc. may influence the distribution of stress and strength random variables. In traditional reliability analysis, these external factors are accounted for by introducing a real-valued distortion function, which replaces the original distribution with a distorted one. However, it’s important to note that the effect of these external factors is not always adequately represented by a single real-valued function. To address this issue, we propose the use of fuzzy numbers within the distortion function. In this paper, we introduce the concept of a "fuzzy distortion function" to incorporate the uncertainty stemming from external factors when estimating the reliability of stress-strength relationships. We present a methodology for estimating fuzzy reliability by employing this fuzzy distortion function. Through an illustrative example, we demonstrate how this approach to estimating fuzzy reliability offers a wider range of possibilities for system reliability and provides more comprehensive insights into the system’s behaviour. Throughout our exploration, we have delved into the diverse properties inherent in fuzzy distortion functions. These properties highlight the versatility and adaptability of such functions in capturing uncertainty within data sets. Moreover, we have scrutinized several methods for constructing fuzzy distortion functions from pre-existing ones. By examining these methods, we gain valuable insights into how fuzzy distortion functions can be tailored to specific contexts and applications, thereby enhancing the accuracy and robustness of reliability analysis in complex systems. Additionally, in the conventional stress-strength model, reliability is determined without considering the uncertainty in the parameters of the distribution function. The drawback of existing methods in the literature is that they do not consider the uncertainty or fuzziness in the parameters of the distribution. Therefore, we estimate the system reliability in the presence of fuzzy parameters in the distribution function of corresponding random variables. The method we discuss in this paper provides a reliability estimate of the given system under realistic situations. A sensitivity analysis study is carried out to examine the behaviour of mean square errors (MSE) of estimated system reliability under various scenarios. It is observed that MSE can be significantly reduced by a suitable choice of parameters in the membership function of fuzzy parameters.
Secretion and N-Linked Glycosylation Are Required for Prostatic Acid Phosphatase Catalytic and Antinociceptive Activity
Creators: name: Hurt, Julie K.
name: Fitzpatrick, Brendan J.
name: Zylka, Mark J.
name: Norris-Drouin, Jacqueline
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Secretory human prostatic acid phosphatase (hPAP) is glycosylated at three asparagine residues (N62, N188, N301) and has potent antinociceptive effects when administered to mice. Currently, it is unknown if these N-linked residues are required for hPAP protein stability and activity in vitro or in animal models of chronic pain. Here, we expressed wild-type hPAP and a series of Asn to Gln point mutations in the yeast Pichia pastoris X33 then analyzed protein levels and enzyme activity in cell lysates and in conditioned media. Pichia secreted wild-type recombinant (r)-hPAP into the media (6–7 mg protein/L). This protein was as active as native hPAP in biochemical assays and in mouse models of inflammatory pain and neuropathic pain. In contrast, the N62Q and N188Q single mutants and the N62Q, N188Q double mutant were expressed at lower levels and were less active than wild-type r-hPAP. The purified N62Q, N188Q double mutant protein was also 1.9 fold less active in vivo. The N301Q mutant was not expressed, suggesting a critical role for this residue in protein stability. To explicitly test the importance of secretion, a construct lacking the signal peptide of hPAP was expressed in Pichia and assayed. This “cellular” construct was not expressed at levels detectable by western blotting. Taken together, these data indicate that secretion and post-translational carbohydrate modifications are required for PAP protein stability and catalytic activity. Moreover, our findings indicate that recombinant hPAP can be produced in Pichia—a yeast strain that is used to generate biologics for therapeutic purposes.
Reinforcement learning-informed queries guide behavioral change - updated
Creators: name: Brown, Vanessa
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Clinical Psychology
subject: Psychiatry and Psychology
subject: Medicine and Health Sciences
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: Updated registration for 'Reinforcement learning-informed queries guide behavioral change'. Updates made at request of editor to fulfill requirements for open data and open materials badges.
Survey # 74
Creators: name: Institut Für Demoskopie Allensbach
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Traffic accidents (2); space travel (1); astrology (1); nuclear weapons (3); extraterrestrials (3); satisfaction with government (4); relations between Germany and Eastern Europe (8); Germany’s position in the world (1); magazines (4); seasoning (18); political knowledge (4); European integration (2); internal conflict in governing coalition (3); German Communist Party (3); smoking habits (4); cigarette brands (2); stationary brands (9); hair product brands (2); floor polish brands (16); soup product brands (3).
RELIABILITY SAMPLING PLAN FOR GENERALIZED INVERTED EXPONENTIALLY DISTRIBUTED UNDER PROGRESSIVE TYPE-II CENSORED DATA
Creators: name: S. Singh
name: A. Kaushik
Publisher: name: Reliability: Theory & Applications
Year: 2024
Subjects: Generalized Inverted Exponential Distribution (GIED)
OC-Curve
Reliability Sampling Plan
Sinulation
Progressive Censoring

description: This article aims to explore a sampling strategy designed to assess the reliability of products that exhibit lifetimes following a GIED. Considered sampling approach has been specially constructed for a Type-II progressive censoring scheme, which includes binomial removals as part of its methodology. Its core objectives is to find out acceptance constant and the optimum sample size. To facilitate practical implementation, the article presents a tabulated form of the sampling plan for the selected specification, as per the considered censoring scheme. To validate the dependability and precision of the suggested sampling approach, we perform a Monte Carlo experiment under various scenarios.
Spatiotemporal Variation in Avian Migration Phenology: Citizen Science Reveals Effects of Climate Change
Creators: name: Hurlbert, Allen H.
name: Liang, Zhongfei
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: A growing number of studies have documented shifts in avian migratory phenology in response to climate change, and yet there is a large amount of unexplained variation in the magnitude of those responses across species and geographic regions. We use a database of citizen science bird observations to explore spatiotemporal variation in mean arrival dates across an unprecedented geographic extent for 18 common species in North America over the past decade, relating arrival dates to mean minimum spring temperature. Across all species and geographic locations, species shifted arrival dates 0.8 days earlier for every °C of warming of spring temperature, but it was common for some species in some locations to shift as much as 3–6 days earlier per °C. Species that advanced arrival dates the earliest in response to warming were those that migrate more slowly, short distance migrants, and species with broader climatic niches. These three variables explained 63% of the interspecific variation in phenological response. We also identify a latitudinal gradient in the average strength of phenological response, with species shifting arrival earlier at southern latitudes than northern latitudes for the same degree of warming. This observation is consistent with the idea that species must be more phenologically sensitive in less seasonal environments to maintain the same degree of precision in phenological timing.
Institut fuer Demoskopie Allensback
Creators: name: Institut Für Demoskopie Allensbach
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: French foreign legion (2); traffic (6); soccer (2); UFOs (2); satisfaction with government (3); German army (2); school curriculum (1); role of church (8); role of political parties (8); knowledge of geography (4); stamps (2); German railway company (2); magazines (3); authors (2); smoking habits (5); hair product brands (8); home spa (4); chocolate consumption (4); soup products (5); cigarette advertising (3); prescription glasses (18); attitudes to foreign countries (1); Germany’s position in the world (1).
Scattering of Line-Ring Vortices in a Superfluid
Creators: name: Villois, Alberto
name: Salman, Hayder
name: Proment, Davide
Publisher: name: arXiv
Year: 2014
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: We study the scattering of vortex rings by a superfluid line vortex using the Gross-Pitaevskii equation in a parameter regime where a hydrodynamic description based on a vortex filament approximation is applicable. By using a vortex extraction algorithm, we are able to track the location of the vortex ring as a function of time. Using this, we show that the scattering of the vortex ring in our Gross-Pitaevskii simulations is well captured by the local induction approximation of a vortex filament model for a wide range of impact parameters. The scattering of a vortex ring by a line vortex is characterised by the initial offset of the centre of the ring from the axis of the vortex. We find that a strong asymmetry exists in the scattering of a ring as a function of this initial scattering parameter.
description: 12 pages, 7 figures
Spontaneous Abortion and a Diet Drug Containing Caffeine and Ephedrine: A Study within the Danish National Birth Cohort
Creators: name: Andersen, Anne-Marie Nybo
name: Nohr, Ellen A.
name: Olsen, Jørn
name: Poole, Charles
name: Bech, Bodil H.
name: Howards, Penelope P.
name: Hertz-Picciotto, Irva
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: BackgroundMedications may be consumed periconceptionally before a woman knows she is pregnant. In this study, the authors evaluate the association of a prescription diet drug (Letigen) containing ephedrine (20 mg) and caffeine (200 mg) with spontaneous abortion (SAB) in the Danish National Birth Cohort.MethodsWomen were recruited during their first prenatal visit from 1996–2002. Pre-conception and early pregnancy medication use was reported on the enrollment form, and pregnancy outcome was determined by linking the mother's Civil Registration Number to the Medical Birth Registry and the National Hospital Discharge Register. Of 97,903 eligible pregnancies, 4,443 ended in SAB between 5 and 20 completed gestational weeks, inclusive. Letigen use was reported for 565 pregnancies. Cox regression models accounting for left truncation were fit to estimate the effect of pre-conception and early pregnancy Letigen use on SAB.Principal FindingsThe estimated maternal age-adjusted hazard ratio for SAB was 1.1 (95% confidence interval 0.8–1.6) for any periconceptional Letigen use compared to no periconceptional use.ConclusionsAlthough Letigen has high levels of caffeine (the recommended 3 pills/day are approximately equivalent to caffeine from 6 cups of coffee), periconceptional use does not appear to be associated with an appreciably increased hazard of clinically recognized SAB.
Single-molecule study for a graphene-based nano-position sensor
Creators: name: Mazzamuto, G.
name: Tabani, A.
name: Pazzagli, S.
name: Rizvi, S.
name: Reserbat-Plantey, A.
name: Schädler, K.
name: Navickaité, G.
name: Gaudreau, L.
name: Cataliotti, F. S.
name: Koppens, F.
name: Toninelli, C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Optics (physics.optics)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In this study we lay the groundwork for a graphene-based fundamental ruler at the nanoscale. It relies on the efficient energy-transfer mechanism between single quantum emitters and low-doped graphene monolayers. Our experiments, conducted with dibenzoterrylene (DBT) molecules, allow going beyond ensemble analysis due to the emitter photo-stability and brightness. A quantitative characterization of the fluorescence decay-rate modification is presented and compared to a simple model, showing agreement with the $d^{-4}$ dependence, a genuine manifestation of a dipole interacting with a 2D material. With DBT molecules, we can estimate a potential uncertainty in position measurements as low as 5nm in the range below 30nm.
ROLE OF AGEING METRICS TO ANALYSE THE SURVIVAL DATA OF TONGUE CANCER PATIENTS
Creators: name: B. Elina
name: Pulak Swain
name: Misra, Satya Kr.
name: Subarna Bhattacharjee
Publisher: name: Reliability: Theory & Applications
Year: 2024
Subjects: survival function
hazard rate
cumulative hazard rate
ageing intensity function. AMS 2020 Subject Classification: Primary 60E15
Secondary 62N05
60E05

description: The paper vividly describes the non-parametric estimation of basic quantities for right censored data of times to death for patients with tongue cancer. Here we compare patients with two different sets of DNA profile using several parameters like reliability function, cumulative hazard rate function, smoothed hazard rate function and ageing intensity function. With the help of graphical representations of these functions, we analyse which DNA profile patients have better prognosis.
Src Kinase Regulation in Progressively Invasive Cancer
Creators: name: Xu, Weichen
name: Allbritton, Nancy
name: Lawrence, David S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Metastatic progression is a multistep process that involves tumor growth and survival, motility and invasion, and subsequent proliferation in an inappropriate environment. The Src protein tyrosine kinase has been implicated in many of the biochemical pathways that drive these behaviors. Although Src itself is only rarely mutated in human tumors, its aberrant activity has been noted in various cancers and suggested to serve as a barometer of metastatic potential. With these features in mind, we examined Src kinase regulation at the structural, enzymatic, and expression levels as a function of progressively invasive prostate cancer cell lines. Surprisingly, both total Src content and kinase activity decrease with increasing cell line aggressiveness, an observation that appears to be inconsistent with the well-documented role of Src in the signaling pathways that drive growth and invasion. However, we do observe a direct correlation between Src kinase specific activity (total Src kinase activity/total Src content) and metastatic aggressiveness, possibly suggesting that in highly aggressive cell lines, key signaling enzymes are globally recruited to drive the cancerous phenotype. In addition, although the expected enhanced phosphorylation of Src at Tyr-416 (activation site) is present in the most aggressive prostate cancer cell lines, unexpectedly high phosphorylation levels at the Tyr-527 inhibitory site are observed as well. The latter, rather than representative of inhibited enzyme, is more indicative of primed Src responsive to local phosphorylated binding partners.
Water distribution in shocked regions of the NGC1333-IRAS4A protostellar outflow
Creators: name: Santangelo, G.
name: Nisini, B.
name: Codella, C.
name: Lorenzani, A.
name: Yildiz, U. A.
name: Antoniucci, S.
name: Bjerkeli, P.
name: Cabrit, S.
name: Giannini, T.
name: Kristensen, L.
name: Liseau, R.
name: Mottram, J. C.
name: Tafalla, M.
name: van Dishoeck, E. F.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present the study of the H2O spatial distribution at two bright shocked regions along IRAS4A, one of the strongest H2O emitters among the Class 0 outflows. We obtained Herschel-PACS maps of the IRAS4A outflow and HIFI observations of two shocked positions. The largest HIFI beam of 38 arcsec at 557 GHz was mapped in several key water lines with different upper energy levels, to reveal possible spatial variations of the line profiles. We detect four H2O lines and CO (16-15) at the two selected positions. In addition, transitions from related outflow and envelope tracers are detected. Different gas components associated with the shock are identified in the H2O emission. In particular, at the head of the red lobe of the outflow, two distinct gas components with different excitation conditions are distinguished in the HIFI emission maps: a compact component, detected in the ground-state water lines, and a more extended one. Assuming that these two components correspond to two different temperature components observed in previous H2O and CO studies, the excitation analysis of the H2O emission suggests that the compact (about 3 arcsec) component is associated with a hot (T~1000 K) gas with densities ~(1-4)x10^5 cm^{-3}, whereas the extended one (10-17 arcsec) traces a warm (T~300-500 K) and dense gas (~(3-5)x10^7 cm^{-3}). Finally, using the CO (16-15) emission observed at R2, we estimate the H2O/H2 abundance of the warm and hot components to be (7-10)x10^{-7} and (3-7)x10^{-5}. Our data allowed us, for the first time, to resolve spatially the two temperature components previously observed with HIFI and PACS. We propose that the compact hot component may be associated with the jet that impacts the surrounding material, whereas the warm, dense, and extended component originates from the compression of the ambient gas by the propagating flow.
description: 13 pages, 11 figures. Accepted for publication in Astronomy and Astrophysics
Statistical Inference for Valued-Edge Networks: The Generalized Exponential Random Graph Model
Creators: name: Cranmer, Skyler J.
name: Desmarais, Bruce A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Across the sciences, the statistical analysis of networks is central to the production of knowledge on relational phenomena. Because of their ability to model the structural generation of networks based on both endogenous and exogenous factors, exponential random graph models are a ubiquitous means of analysis. However, they are limited by an inability to model networks with valued edges. We address this problem by introducing a class of generalized exponential random graph models capable of modeling networks whose edges have continuous values (bounded or unbounded), thus greatly expanding the scope of networks applied researchers can subject to statistical analysis.
SINE-TOPP-LEONE EXPONENTIATED G FAMILY OF DISTRIBUTIONS: PROPERTIES, SURVIVAL REGRESSION AND APPLICATION
Creators: name: A.M. Isa
name: S.I. Doguwa
name: B.B. Alhaji
name: H.G. Dikko
Publisher: name: Reliability: Theory & Applications
Year: 2024
Subjects: Sine-G Family
Topp-Leone Exponentiated G
Survival Analysis
Survival Regression
Maximum Likelihood Estimate

description: In this research article, we have introduced a new class of continuous probability distributions known as the Sine Topp-Leone Exponentiated-G family of distributions. This newly proposed family exhibits a higher degree of flexibility compared to some of the established distribution families. The various models within this family find wide-ranging applications in fields such as physics, engineering, and medicine. Some statistical properties of the Sine Topp-Leone Exponentiated-G family of distributions such as moments, moment generating function, quantile function and order statistics are derived. Two special models were also presented and studies. Maximum likelihood estimation method was used to estimate parameters of the models. The consistency of the proposed family was determine using simulation studies. Two real life datasets were analyzed to show the flexibility of the proposed model and the results of the analysis showed that, the proposed model was more efficient and best fit the data sets than its competitors.
M W helps select Z ' models for b → s ℓ ℓ anomalies.
Creators: name: Allanach, Ben
name: Davighi, Joe
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Regular Article - Theoretical Physics

description: As shown in Allanach et al. (Global fits of third family hypercharge models to neutral current B-anomalies and electroweak precision observables. arXiv:2103.12056), the Third Family Hypercharge ( Y 3 ) Model changes the Standard Model prediction for M W whilst simultaneously explaining anomalies in b → s ℓ ℓ transitions via a heavy Z ' gauge boson which is spawned by a spontaneously broken gauged U ( 1 ) Y 3 symmetry. The 2022 CDF II measurement of M W , which is far from the Standard Model prediction in the statistical sense, somewhat disfavours the Y 3 model. Here, we generalise the gauge charge assignments to the anomaly-free combination s Y 3 + t ( B 3 - L 3 ) and show that incorporating the 2022 CDF II measurement of M W selects a viable domain of integers s and t. For example, s = 1 , t = - 3 yields a p value of .08 in a two-parameter global fit to 277 electroweak and flavour changing b data, much improving a SM p value of 1 × 10 - 6 .
Thermodynamic Casimir Effect in Films: the Exchange Cluster Algorithm
Creators: name: Hasenbusch, Martin
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We study the thermodynamic Casimir force for films with various types of boundary conditions and the bulk universality class of the three-dimensional Ising model. To this end we perform Monte Carlo simulations of the improved Blume-Capel model on the simple cubic lattice. In particular, we employ the exchange or geometric cluster cluster algorithm [J.R. Heringa and H. W. J. Blöte, Phys. Rev. E 57, 4976 (1998)]. In a previous work we demonstrated that this algorithm allows to compute the thermodynamic Casimir force for the plate-sphere geometry efficiently. It turns out that also for the film geometry a substantial reduction of the statistical error can achieved. Concerning physics, we focus on (O,O) boundary conditions, where O denotes the ordinary surface transition. These are implemented by free boundary conditions on both sides of the film. Films with such boundary conditions undergo a phase transition in the universality class of the two-dimensional Ising model. We determine the inverse transition temperature for a large range of thicknesses L_0 of the film and study the scaling of this temperature with L_0. In the neighborhood of the transition, the thermodynamic Casimir force is affected by finite size effects, where finite size refers to a finite transversal extension L of the film. We demonstrate that these finite size effects can be computed by using the universal finite size scaling function of the free energy of the two-dimensional Ising model.
description: 48 pages, 20 figures
Structural Dynamics of Troponin I during Ca2+-Activation of Cardiac Thin Filaments: A Multi-Site Förster Resonance Energy Transfer Study
Creators: name: Chalovich, Joseph M.
name: Wang, Hui
name: Marriott, Gerard
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: A multi-site, steady-state Förster resonance energy transfer (FRET) approach was used to quantify Ca2+-induced changes in proximity between donor loci on human cardiac troponin I (cTnI), and acceptor loci on human cardiac tropomyosin (cTm) and F-actin within functional thin filaments. A fluorescent donor probe was introduced to unique and key cysteine residues on the C- and N-termini of cTnI. A FRET acceptor probe was introduced to one of three sites located on the inner or outer domain of F-actin, namely Cys-374 and the phalloidin-binding site on F-actin, and Cys-190 of cTm. Unlike earlier FRET analyses of protein dynamics within the thin filament, this study considered the effects of non-random distribution of dipoles for the donor and acceptor probes. The major conclusion drawn from this study is that Ca2+ and myosin S1-binding to the thin filament results in movement of the C-terminal domain of cTnI from the outer domain of F-actin towards the inner domain, which is associated with the myosin-binding. A hinge-linkage model is used to best-describe the finding of a Ca2+-induced movement of the C-terminus of cTnI with a stationary N-terminus. This dynamic model of the activation of the thin filament is discussed in the context of other structural and biochemical studies on normal and mutant cTnI found in hypertrophic cardiomyopathies.
Structure and Dynamics of the G121V Dihydrofolate Reductase Mutant: Lessons from a Transition-State Inhibitor Complex
Creators: name: Petit, Chad M.
name: Sapienza, Paul J.
name: Mauldin, Randall V.
name: Lee, Andrew L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: It is well known that enzyme flexibility is critical for function. This is due to the observation that the rates of intramolecular enzyme motions are often matched to the rates of intermolecular events such as substrate binding and product release. Beyond this role in progression through the reaction cycle, it has been suggested that enzyme dynamics may also promote the chemical step itself. Dihydrofolate reductase (DHFR) is a model enzyme for which dynamics have been proposed to aid in both substrate flux and catalysis. The G121V mutant of DHFR is a well studied form that exhibits a severe reduction in the rate of hydride transfer yet there remains dispute as to whether this defect is caused by altered structure, dynamics, or both. Here we address this by presenting an NMR study of the G121V mutant bound to reduced cofactor and the transition state inhibitor, methotrexate. NMR chemical shift markers demonstrate that this form predominantly adopts the closed conformation thereby allowing us to provide the first glimpse into the dynamics of a catalytically relevant complex. Based on 15N and 2H NMR spin relaxation, we find that the mutant complex has modest changes in ps-ns flexibility with most affected residues residing in the distal adenosine binding domain rather than the active site. Thus, aberrant ps-ns dynamics are likely not the main contributor to the decreased catalytic rate. The most dramatic effect of the mutation involves changes in µs-ms dynamics of the F-G and Met20 loops. Whereas loop motion is quenched in the wild type transition state inhibitor complex, the F-G and Met20 loops undergo excursions from the closed conformation in the mutant complex. These excursions serve to decrease the population of conformers having the correct active site configuration, thus providing an explanation for the G121V catalytic defect.
title: Drivers of Turbidity and Its Seasonal Variability at Herschel Island Qikiqtaruk (Western Canadian Arctic)
Creators: name: Klein, Konstantin
name: Lantuit, Hugues
name: Rolph, Rebecca
Publisher: name: Universitätsverlag Potsdam
Year: 2022
Subjects: subject: 690 Hausbau, Bauhandwerk

description: The Arctic is greatly affected by climate change. Increasing air temperatures drive permafrost thaw and an increase in coastal erosion and river discharge. This results in a greater input of sediment and organic matter into nearshore waters, impacting ecosystems by reducing light transmission through the water column and altering biogeochemistry. This potentially results in impacts on the subsistence economy of local people as well as the climate due to the transformation of suspended organic matter into greenhouse gases. Even though the impacts of increased suspended sediment concentrations and turbidity in the Arctic nearshore zone are well-studied, the mechanisms underpinning this increase are largely unknown. Wave energy and tides drive the level of turbidity in the temperate and tropical parts of the world, and this is generally assumed to also be the case in the Arctic. However, the tidal range is considerably lower in the Arctic, and processes related to the occurrence of permafrost have the potential to greatly contribute to nearshore turbidity. In this study, we use high-resolution satellite imagery alongside in situ and ERA5 reanalysis data of ocean and climate variables in order to identify the drivers of nearshore turbidity, along with its seasonality in the nearshore waters of Herschel Island Qikiqtaruk, in the western Canadian Arctic. Nearshore turbidity correlates well to wind direction, wind speed, significant wave height, and wave period. Nearshore turbidity is superiorly correlated to wind speed at the Beaufort Shelf compared to in situ measurements at Herschel Island Qikiqtaruk, showing that nearshore turbidity, albeit being of limited spatial extent, is influenced by large-scale weather and ocean phenomenons. We show that, in contrast to the temperate and tropical ocean, freshly eroded material is the predominant driver of nearshore turbidity in the Arctic, rather than resuspension, which is caused by the vulnerability of permafrost coasts to thermo-erosion.
description: Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe; 1270
Survey # 2045(I), (II)
Creators: name: Institut Für Demoskopie Allensbach
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Personal financial situation (1); minimum required income (1); chocolate brands (2); celebrities (1); cigarette brands (6); satisfaction with Chancellor Kiesinger’s policies (1); vote choice (3); satisfaction with living in Germany (2); German constitution (1); international cooperation (1); mint brands (20); interest in politics (1); attitudes toward political parties (5); attitudes toward politicians (3); political messaging (2); prescription glasses (10); gas firms (2); journalists and commentators (2); traffic regulations (3); international intervention in Germany (2); development aid (6); banning NPD (2); hairpieces (9); satisfaction with Foreign Minister Brandt’s policies (1); most important issue for Germany today (1).
SINGLE AND DOUBLE ACCEPTANCE SAMPLING PLAN FOR TRUNCATED LIFE TESTS BASED ON GAMMA LINDLEY DISTRIBUTION
Creators: name: Sriramachandran, G.V.
Publisher: name: Reliability: Theory & Applications
Year: 2024
Subjects: Acceptance sampling plan
consumer’s risk
producer’s risk
time truncated life test
Gamma Lindley distribution

description: For time-truncated life tests, this work defines single acceptance and double acceptance sampling plans assuming that the product's lifespan follows the Gamma Lindley distribution. The minimum sample size needed in a single acceptance sampling plan for lot approval is calculated for a range of parameter combinations and a fixed test termination time. This ensures the given average product life and the corresponding number of failures. Operational characteristic and producer risk values are also tabulated for these parameter values. Using a double acceptance sampling plan, the best first and second samples are obtained to ensure that the products specified average with a certain level of customer trust. Finally, under the same conditions, the minimum sample size obtained using these strategies are compared with other acceptance sampling plans.
Survey # 2057
Creators: name: Institut Für Demoskopie Allensbach
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Inflation (3); drugs (2); drinking habits (1); celebrities (2); bitters brands (3); satisfaction with Chancellor Kiesinger’s policies (1); federal election outcome (4); attitudes toward new government (5); German firms (1); interior decorating (1); drinks brands (2); underwear (3); divorce law reforms (1); attitudes toward journalists and commentators (1); reading habits (2); personality traits (1); stainless steel artifacts (14); chocolate brands (8); school textbooks (4); gas stations (8); attitudes toward politicians (2); driving habits (5); news sources (1); local news on TV (1); women’s attire in the workplace (3); idioms (1).