cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Serine Protease-Mediated Cutaneous Inflammation
title: Characterization of an Ex Vivo Skin Model for the Assessment of Dexamethasone-Loaded Core Multishell-Nanocarriers
titleType: Subtitle
Creators: name: Frombach, Janna
name: Rancan, Fiorenza
name: Kübrich, Katharina
name: Schumacher, Fabian
name: Unbehauen, Michael
name: Blume-Peytavi, Ulrike
name: Haag, Rainer
name: Kleuser, Burkhard
name: Sabat, Robert
name: Wolk, Kerstin
name: Vogt, Annika
Publisher: name: Freie Universität Berlin
Year: 2020
Subjects: subject: skin barrier
subject: drug delivery
subject: nanotechnology
subject: core-multi shell nanostructure
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::547 Organische Chemie

description: Standard experimental set-ups for the assessment of skin penetration are typically performed on skin explants with an intact skin barrier or after a partial mechanical or chemical perturbation of the stratum corneum, but they do not take into account biochemical changes. Among the various pathological alterations in inflamed skin, aberrant serine protease (SP) activity directly affects the biochemical environment in the superficial compartments, which interact with topically applied formulations. It further impacts the skin barrier structure and is a key regulator of inflammatory mediators. Herein, we used short-term cultures of ex vivo human skin treated with trypsin and plasmin as inflammatory stimuli to assess the penetration and biological effects of the anti-inflammatory drug dexamethasone (DXM), encapsulated in core multishell-nanocarriers (CMS-NC), when compared to a standard cream formulation. Despite a high interindividual variability, the combined pretreatment of the skin resulted in an average 2.5-fold increase of the transepidermal water loss and swelling of the epidermis, as assessed by optical coherence tomography, as well as in a moderate increase of a broad spectrum of proinflammatory mediators of clinical relevance. The topical application of DXM-loaded CMS-NC or DXM standard cream revealed an increased penetration into SP-treated skin when compared to untreated control skin with an intact barrier. Both formulations, however, delivered sufficient amounts of DXM to effectively suppress the production of interleukin-6 (IL-6), interleukin-8 (IL-8) and Thymic Stromal Lymphopoietin (TSLP). In conclusion, we suggest that the herein presented ex vivo inflammatory skin model is functional and could improve the selection of promising drug delivery strategies for anti-inflammatory compounds at early stages of development. View Full-Text
Greening the Car? Conflict Dynamics within the German Platform for Electric Mobility
Creators: name: Richter, Ina
name: Haas, Tobias
Publisher: name: Freie Universität Berlin
Year: 2020
Subjects: subject: electric mobility
subject: Germany
subject: stakeholder participation
subject: sustainability
subject: transformation
subject: transport policy
subject: 600 Technik, Medizin, angewandte Wissenschaften::600 Technik::600 Technik, Technologie

description: The environmental crisis due to air pollution, high CO2 emissions, noise from traffic and soil ceiling requires profound changes to the car-dependent transport system. This article examines the political dynamics of German transport politics, focusing on the National Platform for Electric Mobility (NPE), a high-level political forum that aimed to accelerate the run-up of the electric mobility market in Germany. The NPE provides an interesting case to study the strategies of stakeholders in influencing policy-making and shaping alternative pathways to the car-centered transport system. The paper focusses on actor constellations and the conflicts that arise within the NPE, as well as the temporal dynamics within the electric mobility debate. The findings suggest that the NPE contributed to a narrow understanding of mobility transformation based on road transport and electric cars, but that it is better described as ecological modernization. Within this narrow framework, a fundamental conflict unfolds between strong advocates versus those slowing down the ecological modernization of the car. A third group demands at least a partial departure from the automobile-centered model but remains marginalized within the NPE. Aside from this core conflict, members of the NPE struggled over the location for battery cell production, the introduction of a purchase grant known as the environmental bonus, and the expansion of battery recharging infrastructure. These issues illustrate that discussions within the NPE relate to the political debates about the future of mobility, which have intensified in Germany in recent years. However, the case of the NPE shows that high-level stakeholder platforms are not an adequate forum to legitimately deliberate and to practically contribute to a wider and more fundamental rethink of future mobility concepts. View Full-Text
Matrimonio e famiglia tra laicità e libertà religiosa
Creators: name: Dalla Torre, Giuseppe
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2018

description: SOMMARIO: 1. Premessa: la necessaria precedenza della libertà religiosa sulla laicità - 2. Radici etico-religiose del matrimonio, libertà religiosa e origini del matrimonio civile - 3. Il matrimonio civile: tra neutralità e ideologia - 4. Ritorno del fenomeno religioso nell’età della secolarizzazione: ricadute in materia matrimoniale - 5. La restituzione di matrimonio e famiglia alla società civile e alla religione - 6. La (ri)conquista di spazi di “diritto personale” e ritorno alla disciplina religiosa del matrimonio - 7. Diritto alla tutela dell’identità e “princìpi non negoziabili” dello Stato democratico. Conclusioni. Marriage and family between secularism and religious freedom Abstract: Given that between secularism and religious freedom there is a relationship of instrumentality of the first compared to the second, in the essay there’s a recall to the ethical-religious roots of the marriage’s legislation, which, starting from the Protestant Reformation and then from the French Revolution has undergone a process of secularization and secularism with the birth of the civil marriage. It is a process that has been motivated (also) by reasons of religious freedom, but which has led, by the State, to the subtraction of the marriage’s subject from the society. Today there is a substantial return from the state to the society of the discipline about the various forms of life and family communions, and this, in a religiously pluralistic society, involves (also) the return of the marriage to the religion.
description: Stato, Chiese e pluralismo confessionale, 2018: 11 giugno
Volcanism from different eruption cycles during the Early Cretaceous in the Changling fault depression of the songliao basin, NE China, and their implications for timing of lithospheric thinning
Creators: name: Liu, Chaoyang
name: Shan, Xuanlong
name: Yi, Jian
name: Ren, Xianjun
name: Han, Jiaoyan
name: Niu, Penghui
name: Xing, Jian
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Late Mesozoic lithospheric extension in NE China resulted in the development of a large extensional province and widespread formation of volcanic-sedimentary basins. The Songliao Basin is the largest one and contains voluminous volcanic rocks composing the majority of the basin fill. This study focuses on two adjacent eruption cycles, the Huoshiling Formation (K1h) and the first member of the Yingcheng Formation (K1yc1), in the Changling fault depression of the Songliao basin, constrains their time ranges and compares the origins of volcanic rocks. Zircon populations from K1h yield U-Pb ages of 124–118 Ma; those from K1yc1 yield younger ones (115–106 Ma). Different volcanic rocks are identified in K1h (alkaline basic rocks, calc-alkaline intermediate-acid rocks) and K1yc1 (alkaline basic rocks, A-type rhyolites), and their geochemistry and isotope characteristics confirm their different origins. The alkaline basic rocks from K1h have the similar magma source as those from K1yc1; both formed under within-plate conditions from an ocean island basalt (OIB)-type mantle source, assumed to be the heterogeneous shallow asthenosphere. The calc-alkaline intermediate-acid volcanic rocks from K1h formed by fractional crystallization of magma, related to the enriched lithospheric mantle, whereas the A-type rhyolites from K1yc1 directly originated from the partial melting of crust newly formed from the depleted mantle. The development of alkaline basic rocks and A-type acid rocks, a typical bimodal volcanic assemblage in K1yc1, requires a relatively thin lithosphere and thus implies that lithospheric thinning reached its maximum during this time (115–106 Ma). However, the rare expression of alkaline basic rocks and the formation of acid rocks mainly by fractional crystallization in K1h indicate that the lithosphere was relatively thick; during this time (124–118 Ma), the lithosphere below the Songliao Basin had just begun thinning. These different stages of lithospheric extension may be due to the intermittent rollback of the Palaeo-Pacific Plate.
Crossing and Conversion among North Korean Refugee-Migrants
Creators: name: Jung, Jin-Heon
Publisher: name: Freie Universität Berlin
Year: 2020
Subjects: subject: North Korean refugee-migrants
subject: crossing
subject: religious conversion
subject: aspirations
subject: 200 Religion::200 Religion::200 Religion

description: While pivotal in the lives of North Korean refugee-migrants, the role of religion has been largely neglected in most studies. After being exposed to Protestant missionary networks, either while dwelling in Northeast China or en route to the South, about 80 percent of North Korean refugee-migrants arriving in South Korea affiliate themselves with Protestant churches. This implies that they are exposed to Protestant missionary networks either while dwelling in Northeast China or en route to the South. Some who leave South Korea for other countries or seek asylum in non-Korean societies develop their religiosity in various ways and for various reasons, as part of their aspirations, adjustment to new homes, and search for meaning. The present study aims to address this literature gap. Based on long-term ethnographic research with North Korean refugee-migrants living in South Korea, China, and Europe, the two ethnographic vignettes presented in this article represent those who are in Germany and the United Kingdom by discussing the religious encounters and conversions through which North Korean refugee-migrants make their lives and futures. It draws attention to religion as a lens through which the migrants’ negotiation of meanings, new selves and homelands, and hopes for the future can be better illuminated. The findings of this study suggest that when North Korean Christians experience religious conversion during their perilous journeys, it not only helps them to negotiate a new sense of belonging in their host societies, but it also mobilizes them to contest the existing order of things.
Un “modello Unesco” per la gestione, in chiave economica, dei beni culturali di interesse religioso?
Creators: name: Tigano, Marta
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2018

description: SOMMARIO: 1. Considerazioni introduttive - 2. Premesse a una ricostruzione dello statuto dei beni culturali - 3. Il passaggio da una tutela “statica” a una valorizzazione “in chiave dinamica” - 4. Inquadramento dell’attività di valorizzazione nell’ambito dei “servizi pubblici” - 5. La possibile estensione dei processi di gestione (e di valorizzazione) ideati per i beni culturali “laici” - e ispirati a criteri economici - anche ai beni culturali di interesse religioso: la necessità dell’accordo - 6. L’organizzazione di un “servizio alla cultura” ispirato a criteri di natura economica - 7. Tentativo di individuazione dei beni culturali di interesse religioso e possibile compatibilità della gestione secondo criteri economici con la natura di questi ultimi - 8. Beni culturali religiosi e “mistero” di salvezza - 9. La programmazione e la pianificazione delle attività relative ai beni culturali (di appartenenza pubblica e non) ed esempi di modelli “condivisi”. An "UNESCO model" for the economic management of cultural heritage of religious interest? ABSTRACT: The article is intended to verify if the "UNESCO" management model is applicable to the management of cultural heritage of religious interest, tout court, or if, otherwise, special arrangement are required. Indeed, the UNESCO one is a model not only of dualistic management, (which implies a bilateral agreement), but moreover is inspired by purely economic management criteria. The question is whether a model created for secular cultural heritage can be assumed as a management model also for cultural heritage of religious interest, whose purpose would seem to be incompatible with the characteristics of purely economic management. The author tries to give an answer identifying the common features between the two categories of heritage.
description: Stato, Chiese e pluralismo confessionale, 2018: 18 giugno
The Industrial Organism Corynebacterium glutamicum Requires Mycothiol as Antioxidant to Resist Against Oxidative Stress in Bioreactor Cultivations
Creators: name: Hartmann, Fabian Stefan Franz
name: Clermont, Lina
name: Tung, Quach Ngoc
name: Antelmann, Haike
name: Seibold, Gerd Michael
Publisher: name: Freie Universität Berlin
Year: 2020
Subjects: subject: Corynebacterium glutamicum
subject: oxidative stress
subject: mycothiol
subject: Mrx1-roGFP2
subject: redox potential
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: In aerobic environments, bacteria are exposed to reactive oxygen species (ROS). To avoid an excess of ROS, microorganisms are equipped with powerful enzymatic and non-enzymatic antioxidants. Corynebacterium glutamicum, a widely used industrial platform organism, uses mycothiol (MSH) as major low molecular weight (LMW) thiol and non-enzymatic antioxidant. In aerobic bioreactor cultivations, C. glutamicum becomes exposed to oxygen concentrations surpassing the air saturation, which are supposed to constitute a challenge for the intracellular MSH redox balance. In this study, the role of MSH was investigated at different oxygen levels (pO2) in bioreactor cultivations in C. glutamicum. Despite the presence of other highly efficient antioxidant systems, such as catalase, the MSH deficient ΔmshC mutant was impaired in growth in bioreactor experiments performed at pO2 values of 30%. At a pO2 level of 20%, this growth defect was abolished, indicating a high susceptibility of the MSH-deficient mutant towards elevated oxygen concentrations. Bioreactor experiments with C. glutamicum expressing the Mrx1-roGFP2 redox biosensor revealed a strong oxidative shift in the MSH redox potential (EMSH) at pO2 values above 20%. This indicates that the LMW thiol MSH is an essential antioxidant to maintain the robustness and industrial performance of C. glutamicum during aerobic fermentation processes. View Full-Text
Haemaphysalis shimoga Trapido and Hoogstraal 1964
Creators: name: Petney, Trevor N.
name: Boulanger, Nathalie
name: Saijuntha, Weerachai
name: Chitimia-Dobler, Lidia
name: Pfeffer, Martin
name: Eamudomkarn, Chatanun
name: Andrews, Ross H.
name: Ahamad, Mariana
name: Putthasorn, Noppadon
name: Muders, Senta V.
name: Petney, David A.
name: Robbins, Richard G.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Ixodida
Ixodidae
Haemaphysalis
Haemaphysalis shimoga

description: Haemaphysalis shimoga Trapido and Hoogstraal, 1964
 Haemaphysalis shimoga was described from Shimoga District of Mysore State in southern India (Trapido and Hoogstraal 1964). Since that time, it has also been reported from Cambodia, Myanmar, Thailand and Vietnam (Tanskul et al. 1983; Tanskul and Inlao 1989; Kolonin 1995). Adults are known to feed on sambar deer and gaur, although they have also been recorded from cattle, sheep, goats and humans (Rajagopalan et al. 1968; Bhat et al. 1974a; Tanskul et al. 1983; Geevarghese and Mishra 2011). Immatures are known from rodents (Kolonin 1995). The laboratory life cycle is given in Bhat et al. (1974a) and Geevarghese and Mishra (2011).
 All life history stages are described in Trapido and Hoogstraal (1964). Trapido et al. (1964b) illustrate the larval capitulum and the nymphal capitulum, coxae and trochanters.
description: Published as part of Petney, Trevor N., Boulanger, Nathalie, Saijuntha, Weerachai, Chitimia-Dobler, Lidia, Pfeffer, Martin, Eamudomkarn, Chatanun, Andrews, Ross H., Ahamad, Mariana, Putthasorn, Noppadon, Muders, Senta V., Petney, David A. & Robbins, Richard G., 2019, Ticks (Argasidae, Ixodidae) and tick-borne diseases of continental Southeast Asia, pp. 1-89 in Zootaxa 4558 (1) on pages 28-29, DOI: 10.11646/zootaxa.4558.1.1, http://zenodo.org/record/2613120
Definition of Core Bacterial Taxa in Different Root Compartments of Dactylis glomerata, Grown in Soil under Different Levels of Land Use Intensity
Creators: name: Estendorfer, Jennifer
name: Stempfhuber, Barbara
name: Vestergaard, Gisle
name: Schulz, Stefanie
name: Rillig, Matthias C.
name: Joshi, Jasmin
name: Schröder, Peter
name: Schloter, Michael
Publisher: name: Freie Universität Berlin
Year: 2020
Subjects: subject: land use intensity
subject: plant-associated microbiome
subject: endophytes
subject: rhizosphere
subject: biodiversity
subject: bacteria
subject: core microbiome
subject: Pseudomonas
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Plant-associated bacterial assemblages are critical for plant fitness. Thus, identifying a consistent plant-associated core microbiome is important for predicting community responses to environmental changes. Our target was to identify the core bacterial microbiome of orchard grass Dactylis glomerata L. and to assess the part that is most sensitive to land management. Dactylis glomerata L. samples were collected from grassland sites with contrasting land use intensities but comparable soil properties at three different timepoints. To assess the plant-associated bacterial community structure in the compartments rhizosphere, bulk soil and endosphere, a molecular barcoding approach based on high throughput 16S rRNA amplicon sequencing was used. A distinct composition of plant-associated core bacterial communities independent of land use intensity was identified. Pseudomonas, Rhizobium and Bradyrhizobium were ubiquitously found in the root bacterial core microbiome. In the rhizosphere, the majority of assigned genera were Rhodoplanes, Methylibium, Kaistobacter and Bradyrhizobium. Due to the frequent occurrence of plant-promoting abilities in the genera found in the plant-associated core bacterial communities, our study helps to identify “healthy” plant-associated bacterial core communities. The variable part of the plant-associated microbiome, represented by the fluctuation of taxa at the different sampling timepoints, was increased under low land use intensity. This higher compositional variation in samples from plots with low land use intensity indicates a more selective recruitment of bacteria with traits required at different timepoints of plant development compared to samples from plots with high land use intensity.
contenuti - di Giuseppe D'Angelo Tra libertà di religione e istanze di sicurezza: la prevenzione della radicalizzazione jihadista in fase di esecuzione della pena
Creators: name: Milani, Daniela
name: Negri, Alessandro
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2018

description: SOMMARIO: 1. Carcere e religione - 2. Pluralismo religioso e istanze di sicurezza - 3. Strategie di contrasto al proselitismo e alla radicalizzazione jihadista - 4. Gli ‘indicatori sulla radicalizzazione’ - 5. Le questioni aperte: prevenzione e de-radicalizzazione - 6. Cosa fare. Between religious freedom and security issues: the prevention of jihadist radicalisation in prison ABSTRACT: Faith constitutes an essential aspect of prison life. Its relevance has been emphasised in recent times because of the religious pluralism that characterises the current prison population. In this scenario, the rise of jihadist terrorism has shed light on the problem of radicalisation in prison, already known and studied by the experts, which poses new challenges for policymakers, prison staff, and detainees. Prison Administration has been focused on religious freedom, its boundaries and its relationship with religious extremism and has already adopted some measures to combat and monitor jihadist proselitism in Italian prisons. This paper provides an overview of these anti-radicalisation strategies in prisons, highlighting unresolved issues. These include the lack of an integrated plan with regards to prevention of radicalisation and de-radicalisation, not limited by the prison context. This paper further highlights the challenges in devising policies that address security concerns without sacrificing religious freedom and diversity, as provided for by the Constitution.
description: Stato, Chiese e pluralismo confessionale, 2018: 18 giugno
Tofacitinib Loaded Squalenyl Nanoparticles for Targeted Follicular Delivery in Inflammatory Skin Diseases
Creators: name: Christmann, Rebekka
name: Ho, Duy-Khiet
name: Wilzopolski, Jenny
name: Lee, Sangeun
name: Koch, Marcus
name: Loretz, Brigitta
name: Vogt, Thomas
name: Bäumer, Wolfgang
name: Schaefer, Ulrich F.
name: Lehr, Claus-Michael
Publisher: name: Freie Universität Berlin
Year: 2020
Subjects: subject: targeted drug delivery
subject: hair follicle
subject: in vivo allergic dermatitis mouse model
subject: follicular delivery
subject: interfollicular delivery
subject: nanoparticles
subject: squalene
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik

description: Tofacitinib (TFB), a Janus kinase inhibitor, has shown excellent success off-label in treating various dermatological diseases, especially alopecia areata (AA). However, TFB’s safe and targeted delivery into hair follicles (HFs) is highly desirable due to its systemic adverse effects. Nanoparticles (NPs) can enhance targeted follicular drug delivery and minimize interfollicular permeation and thereby reduce systemic drug exposure. In this study, we report a facile method to assemble the stable and uniform 240 nm TFB loaded squalenyl derivative (SqD) nanoparticles (TFB SqD NPs) in aqueous solution, which allowed an excellent loading capacity (LC) of 20%. The SqD NPs showed an enhanced TFB delivery into HFs compared to the aqueous formulations of plain drug in an ex vivo pig ear model. Furthermore, the therapeutic efficacy of the TFB SqD NPs was studied in a mouse model of allergic dermatitis by ear swelling reduction and compared to TFB dissolved in a non-aqueous mixture of acetone and DMSO (7:1 v/v). Whereas such formulation would not be acceptable for use in the clinic, the TFB SqD NPs dispersed in water illustrated a better reduction in inflammatory effects than plain TFB’s aqueous formulation, implying both encouraging good in vivo efficacy and safety. These findings support the potential of TFB SqD NPs for developing a long-term topical therapy of AA.
L’accesso dei ministri di culto islamici negli istituti di detenzione, tra antichi problemi e prospettive di riforma. L’esperienza del Protocollo tra Dipartimento dell’Amministrazione penitenziaria e UCOII
Creators: name: Angeletti, Silvia
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2018

description: SOMMARIO: 1. L’Islam tra le mura del carcere: le ragioni di un intervento, gli obiettivi del Protocollo - 2. Uno spiraglio di libertà: la fede in regime di detenzione, le garanzie normative e le risposte alla diversità religiosa - 3. Mediatori o ministri di culto? Un ruolo ‘sospeso’ tra definizioni giuridiche e prassi - 4. Visitate i detenuti: La questione dell’ingresso negli istituti detentivi, criticità applicative e novità del Protocollo - 5. Conclusioni. Granting Islamic religious ministers admission to prisons, amid long-lasting issues and reformation perspectives. The Agreement between the Prison Administration Department and the Islamic Communities Union. ABSTRACT: As religious diversity in Italian prisons grows, accommodating prisoners’ religious needs tries legal paradigms and instruments out. In 2015 the Prison Administration Department signed an agreement with UCOII, one of the largest Islamic associations in Italy, in order to grant admission in prisons to intercultural mediators and religious ministers. This article seeks to situate the covenant in the wider context of the Italian legal protection of religious freedom in prison, highlighting three main purposes of the agreement: providing Islamic prisoners with religious assistance, enforcing rehabilitative programs and combating violent radicalization in jail. After two years the experience has shown good evidences. Nonetheless, contended issues still remain unsettled. While evaluating feasible solutions, the article advocates a legislative intervention that could assess criteria and procedures for religious ministers’ access to prisons fulfilling the principle of equality and non-discrimination.
description: Stato, Chiese e pluralismo confessionale, 2018: 25 giugno
Poteri disciplinari della gerarchia ecclesiastica e diritto penale dello Stato (a proposito del rinvio a giudizio del Vescovo di Prato)
Creators: name: Bellini, Piero
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2018

description: SOMMARIO: I. Premessa. - 2, 3, 4, 5. Concorrenza del diritto dello Stato e della Chiesa a qualificare i medesimi comportamenti: possibili conflitti. - 6, 7, 8, 9. Valutazione canonistica del problema. Illiceità del matrimonio civile fra cattolici. Questione dei limiti concordatari ai poteri punitivi dei superiori ecclesiastici in Italia. Valutazione della questione sotto il profilo dell’opportunità canonica. - 10, 11, 12, 13. Sua valutazione statualistica. Posizione del diritto della Chiesa rispetto a quello dello Stato. Natura del rapporto fra fedele e superiore ecclesiastico pel nostro ordinamento. Conseguenze. - 14, 15, 16, 17. Delimitazione del jus libertatis Ecclesiae. Limiti funzionali. - 18. Limiti obiettivi. - 19. Conclusione.
description: Stato, Chiese e pluralismo confessionale, 2018: 25 giugno
“Rigore e curiosità. Scritti in memoria di Maria Cristina Folliero”. Motivazioni e contenuti
Creators: name: D'Angelo, Giuseppe
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2018

description: 1 - Avendo il compito di presentare gli Scritti, debbo provare ad andare oltre l’affetto, oltre la commozione. Anche perché proprio la professoressa Folliero non mi avrebbe certo perdonato smarginamenti. E allora, desidero anzitutto ringraziarvi, ringraziare questa Università, i Colleghi di questa Università e ringraziare in particolar modo l’ADEC nella persona del Presidente e dei componenti del Direttivo per avere pensato a questo Atto accademico in memoria della professoressa Folliero e avervi incluso, affidandomela, la presentazione degli Scritti a Lei dedicati. Ringrazio Gianni Cimbalo, per la ricostruzione puntuale e avvertita del profilo scientifico della studiosa, il toccante ricordo della persona e per le emozioni che ha rinnovato, credo non soltanto a me.
description: Stato, Chiese e pluralismo confessionale, 2018: 25 giugno
Resolved Influenza A Virus Infection Has Extended Effects on Lung Homeostasis and Attenuates Allergic Airway Inflammation in a Mouse Model
Creators: name: Wu, Qingyu
name: Jorde, Ilka
name: Kershaw, Olivia
name: Jeron, Andreas
name: Bruder, Dunja
name: Schreiber, Jens
name: Stegemann-Koniszewski, Sabine
Publisher: name: Freie Universität Berlin
Year: 2020
Subjects: subject: influenza A virus
subject: allergic asthma
subject: allergic airway inflammation
subject: respiratory immune regulation
subject: pro-inflammatory cytokines
subject: macrophages
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::632 Schäden, Krankheiten, Schädlinge an Pflanzen

description: Allergic airway inflammation (AAI) involves T helper cell type 2 (Th2) and pro-inflammatory responses to aeroallergens and many predisposing factors remain elusive. Influenza A virus (IAV) is a major human pathogen that causes acute respiratory infections and induces specific immune responses essential for viral clearance and resolution of the infection. Beyond acute infection, IAV has been shown to persistently affect lung homeostasis and respiratory immunity. Here we asked how resolved IAV infection affects subsequently induced AAI. Mice infected with a sublethal dose of IAV were sensitized and challenged in an ovalbumin mediated mouse model for AAI after resolution of the acute viral infection. Histological changes, respiratory leukocytes, cytokines and airway hyperreactivity were analyzed in resolved IAV infection alone and in AAI with and without previous IAV infection. More than five weeks after infection, we detected persistent pneumonia with increased activated CD4+ and CD8+ lymphocytes as well as dendritic cells and MHCII expressing macrophages in the lung. Resolved IAV infection significantly affected subsequently induced AAI on different levels including morphological changes, respiratory leukocytes and lymphocytes as well as the pro-inflammatory cytokine responses, which was clearly diminished. We conclude that IAV has exceptional persisting effects on respiratory immunity with substantial consequences for subsequently induced AAI.
Study on the Influence of Chirality in the Threading of Calix[6]arene Hosts with Dialkylammonium Axles
Creators: name: Talotta, Carmen
name: Concilio, Gerardo
name: Della Sala, Paolo
name: Gaeta, Carmine
name: Schalley, Christoph A.
name: Neri, Placido
Publisher: name: Freie Universität Berlin
Year: 2020
Subjects: subject: calixarenes
subject: threading
subject: chirality
subject: barfate salts
subject: pseudorotaxane
subject: chiral axles
subject: chiral wheels
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: The influence of chirality in calixarene threading has been studied by exploiting the “superweak anion approach”. In particular, the formation of chiral pseudo[2]rotaxanes bearing a classical stereogenic center in their axle and/or wheel components has been considered. Two kind of pseudo[2]rotaxane stereoadducts, the “endo-chiral” and “exo-chiral” ones, having the stereogenic center of a cationic axle inside or outside, respectively, the calix-cavity of a chiral calixarene were preferentially formed with specifically designed chiral axles by a fine exploitation of the so-called “endo-alkyl rule” and a newly defined “endo-α-methyl-benzyl rule” (threading of a hexaalkoxycalix[6]arene with a directional (α-methyl-benzyl)benzylammonium axle occurs with an endo-α-methyl-benzyl preference). The obtained pseudorotaxanes were studied in solution by 1D and 2D NMR, and in the gas-phase by means of the enantiomer-labeled (EL) mass spectrometry method, by combining enantiopure hosts with pseudoracemates of one deuterated and one unlabeled chiral axle enantiomer. In both instances, there was not a clear enantiodiscrimination in the threading process with the studied host/guest systems. Possible rationales are given to explain the scarce reciprocal influence between the guest and host chiral centers.
Acid Sphingomyelinase Impacts Canonical Transient Receptor Potential Channels 6 (TRPC6) Activity in Primary Neuronal Systems
Creators: name: Zeitler, Stefanie
name: Schumacher, Fabian
name: Monti, Juliana
name: Anni, Daniela
name: Guhathakurta, Debarpan
name: Kleuser, Burkhard
name: Friedland, Kristina
name: Fejtová, Anna
name: Kornhuber, Johannes
name: Rhein, Cosima
Publisher: name: Freie Universität Berlin
Year: 2020
Subjects: subject: acid sphingomyelinase
subject: sphingolipids
subject: trpc6
subject: major depressive disorder
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik

description: The acid sphingomyelinase (ASM)/ceramide system exhibits a crucial role in the pathology of major depressive disorder (MDD). ASM hydrolyzes the abundant membrane lipid sphingomyelin to ceramide that regulates the clustering of membrane proteins via microdomain and lipid raft organization. Several commonly used antidepressants, such as fluoxetine, rely on the functional inhibition of ASM in terms of their antidepressive pharmacological effects. Transient receptor potential canonical 6 (TRPC6) ion channels are located in the plasma membrane of neurons and serve as receptors for hyperforin, a phytochemical constituent of the antidepressive herbal remedy St. John’s wort. TRPC6 channels are involved in the regulation of neuronal plasticity, which likely contributes to their antidepressant effect. In this work, we investigated the impact of reduced ASM activity on the TRPC6 function in neurons. A lipidomic analysis of cortical brain tissue of ASM deficient mice revealed a decrease in ceramide/sphingomyelin molar ratio and an increase in sphingosine. In neurons with ASM deletion, hyperforin-mediated Ca2+-influx via TRPC6 was decreased. Consequently, downstream activation of nuclear phospho-cAMP response element-binding protein (pCREB) was changed, a transcriptional factor involved in neuronal plasticity. Our study underlines the importance of balanced ASM activity, as well as sphingolipidome composition for optimal TRPC6 function. A better understanding of the interaction of the ASM/ceramide and TRPC6 systems could help to draw conclusions about the pathology of MDD.
Canadian Gallup Poll # 1984-481-2: Government/Political Parties
Creators: name: Canadian Institute Of Public Opinion (Gallup)
Publisher: name: Roper Center for Public Opinion Research
Year: 2022

description: Federal election vote intent (1); past federal elections vote (1); parties and issues (4); Canada-US relations (1); confidence in US (1); pension plans (2); major political parties approval (3); Western nations to assist poor countries of the Third World (1); availability of health care in Canada (1); Prime Minister and the opposition leader job performance (3).
Riflessi canonistici della riforma del Terzo settore
Creators: name: Bettetini, Andrea
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2018

description: SOMMARIO: 1. Premessa. Specificità dell’ente ecclesiastico e diritto comune - 2. Lo scopo di religione o di culto. Finalità canoniche e finalità “pattuite”: antinomie e analogie - 3. Attività di interesse generale” di cui all’art. 5 d.lgs. n. 117 del 2017, missione caritativa e sociale della Chiesa e regolamentazione delle attività “diverse” da quelle di culto e religione - 4. Gli enti religiosi civilmente riconosciuti e la novella disciplina sugli enti del Terzo settore e dell’Impresa sociale: adempimenti canonici (regolamento, licenza scritta dell’ordinario e creazione di un patrimonio destinato) - 5. L’identificazione dei beni dell’ente canonico funzionali all’esercizio dell’attività di Terzo settore o di Impresa sociale: il bilancio separato. Conclusioni. Canonistic Reflections of the Reform of the Third Sector ABSTRACT: Third sector reform started with the delegation law n. 106 of 6 June 2016 undoubtedly involves canon law in its form and substance. The new legislation on the Third sector allows in a certain sense to "recover" many of the typically canonical activities of the religious entity within its "civil" structure in a way more coherent with the religious and canonical nature of the institution itself with respect to the law 222 of 1985. If we look at the activities that Legislative Decree 117 of 2017 calls (Article 5) "Activities of general interest", we highlight how many of them are specific and characterizing religious bodies of the Catholic tradition. The Author in particular highlights how the civilly recognized religious bodies, if they want to regulate some of their activities according to the new discipline on Third sector bodies and the Social enterprise, must undergo some canonical obligations (drafting of a regulation, written license of the Ordinary and creation of destined assets).
description: Stato, Chiese e pluralismo confessionale, 2018: 28 maggio
Additional file 1 of Perfluoroalkyl substances (PFASs) as risk factors for breast cancer: a case–control study in Chinese population
Creators: name: Li, Xuejun
name: Song, Fengju
name: Liu, Xiaotu
name: Shan, Anqi
name: Huang, Yubei
name: Yang, Zhengjun
name: Li, Haixin
name: Yang, Qiaoyun
name: Yu, Yue
name: Zheng, Hong
name: Cao, Xu-Chen
name: Chen, Da
name: Chen, Ke-Xin
name: Chen, Xi
name: Tang, Nai-jun
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology

description: Additional file 1.
Towards ultrafast single photon spectroscopy with trapped molecular ions
Creators: name: Zhenlin Wu
name: Walser, Stefan
name: Podlesnic, Verena
name: Schindler, Philipp
Publisher: name: Zenodo
Year: 2022

description: Poster given at : FRIAS Junior Researcher Conference - Cold and ultracold chemistry in Freiburg, 20.02.-22.02.2022
La tutela dell’identità delle minoranze religiose deve potersi avvalere di “un giudice e un giudizio” (ancora sulla sentenza della Corte costituzionale n. 52 del 2016)
Creators: name: Casuscelli, Giuseppe
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2018

description: SOMMARIO: 1- La qualificazione giuridica è attribuzione costituzionale esclusiva del potere giudiziario - 2. La qualificazione giuridica delle confessioni religiose … - 3. (segue) e il loro diritto all’identità - 4. L’espediente del “doppio binario” - 5. L’insopprimibile garanzia della tutela giurisdizionale dei diritti è (ancora) principio supremo dell’ordinamento costituzionale - 6. Il petitum del ricorso per conflitto di attribuzioni tra poteri dello Stato, e l’obbligo di attenersi al thema decidendum - 7. I poteri del Governo nell’esame dell’istanza di accesso all’intesa - 8. Le improvvide conseguenze dell’avere ritenuto il diniego governativo “atto politico”: dal “pluralismo aperto” al “pluralismo discrezionalmente regolamentato”. For the protection of their identity, religious minorities should have “a judge and a judgment” at their disposal (again on the judgment of the Constitutional Court no. 52 of 2016) ABSTRACT: The article links the theme of the legal qualification of an association that calls itself a “religious confession” in order to have relationships with the State, according to the provisions laid down in the third paragraph of art. 8 of the Constitution, with the theme of the right of religious minorities to have an identity. It intends to prove that the document that the government issues in order to deny such a qualification is not a “political action” exempt from the control of the judicial authority, contrary to ruling no. 52 of 2016 of the Constitutional Court. The identity of religious minorities is protected by the guarantees offered by art. 24 of the Constitution, from which the Constitutional Court draws the supreme principle of jurisdictional protection of rights, the foundation of any democratic system, that guarantees to all, for any dispute, “a judge and a judgment”.
description: Stato, Chiese e pluralismo confessionale, 2018: 4 giugno
Mediazione e Religioni: la sfida in una società complessa
Creators: name: Berlingò, Salvatore
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2018

description: SOMMARIO: 1. Annotazioni preliminari - 2. Complessità sociale e complessità giuridica - 3. Modalità alternative di composizione delle controversie - 4. Dal diritto imposto (Ge-setz) al diritto mediato e/o partecipativo - 5. Complementarità fra sostegno politico dei diritti e mediazione dialogica delle fedi - 6. Le (non facili) condizioni di praticabilità del modello di complementarità/distinzione - 7. L’irriducibilità della sfera religioso-fideistica alla sfera politica - 8. Alcune clausole di salvaguardia per le prospettive avvenire. Mediation and Religions: the challenge in a complex society ABSTRACT: Globalization makes social relations increasingly complex, because it favors the introduction and the spread in the same sphere of a plurality of cultures that are often difficult to combine. The proper task of law, that is the one of regulating the cohabitation of people in an equitable manner, is harder in this context, but it can be enhanced with the help of the mediation carried out by religious communities, though the criterion of complementarity/distinction between the order of political conventions and the order of religious convictions is respected.
description: Stato, Chiese e pluralismo confessionale, 2018: 11 giugno
Prevalence and Epidemiology of Multidrug-Resistant Pathogens in the Food Chain and the Urban Environment in Northwestern Germany
Creators: name: Klees, Sylvia
name: Effelsberg, Natalie
name: Stührenberg, Birgit
name: Mellmann, Alexander
name: Schwarz, Stefan
name: Köck, Robin
Publisher: name: Freie Universität Berlin
Year: 2020
Subjects: subject: antimicrobial resistance
subject: food safety
subject: one health
subject: zoonosis
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::636 Viehwirtschaft

description: The surveillance of antimicrobial resistance among humans and food-producing animals is important to monitor the zoonotic transmission of multidrug-resistant bacteria (MDRB). We assessed the prevalence of four MDRB within the meat production chain, including extended-spectrum β-lactamase (ESBL)-producing, carbapenemase-producing Enterobacterales (CPE) and colistin-resistant Enterobacterales (Col-E), as well as vancomycin-resistant enterococci (VRE). In total, 505 samples from four stages of meat production, i.e., slaughterhouses, meat-processing plants, fresh food products and the urban environment, were collected in northwestern Germany in 2018/2019 and screened for the presence of MDRB using both culture-based and PCR-based techniques. We detected genes encoding for carbapenemases in 9–56% (blaOXA-48, blaKPC, blaNDM, blaVIM) and colistin resistance-encoding mcr genes in 9–26% of the samples from all stages. Culture-based analysis found CPE and VRE only in environmental samples (11% and 7%, respectively), but Col-E and ESBL-producers in 1–7% and 12–46% of samples from all stages, respectively. Overall, our results showed that ESBL-producers and mcr-carrying Col-E were common in food-producing animals at slaughterhouses, in meat-processing plants and in food items at retail, while CPE and VRE were only found in the environment. The discrepancy between detected carbapenemase genes and isolated CPE emphasizes the need for more sensitive detection methods for CPE monitoring.
Enti ecclesiastici e riforma del Terzo settore. Profili canonistici
Creators: name: Cavana, Paolo
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2018

description: SOMMARIO: 1. Riforma del Terzo settore e servizio della carità nella Chiesa - 2. La riforma del Terzo settore e le nuove sfide per gli enti ecclesiastici - 3. Il Motu proprio “Intima Ecclesiae natura” e l’evoluzione dell’ordinamento canonico - 4. Il Codice del Terzo settore e la sua applicazione agli enti ecclesiastici - 5. Implicazioni per gli enti della Chiesa: l’esigenza di trasparenza - 6. Il principio della trasparenza nella dottrina canonistica - 7. Il “patrimonio destinato”: implicazioni nell’ordinamento canonico - 8. Attività diverse e controlli canonici: la sfida della governance e della gestione in un contesto concordatario - 9. Osservazioni conclusive. Catholic Church entities and the reform of the Third sector in Italian legislation. Canonical implications ABSTRACT: This paper deals with the canonical implications of Italy’s recent Third sector reform in Italian legislation (d. lgs n. 117/2017) for Catholic Church entities and/or agencies for charitable purposes. It starts with some preliminary remarks on the recent evolution of Canon Law concerning the discipline of charitable organizations and agencies that followed the Motu proprio Intima Ecclesiae natura, issued by Pope Benedict XVI in December 2012. It then examines the general framework of the new regulation of non profit organizations in Italian law, emphasizing the pros and cons (opportunities and risks) of its application to religious entities, particularly those connected to the Catholic Church, which in Italy traditionally enjoy a special discipline safeguarding their canonical structure and purposes. The paper then focuses on the impact of the new civil regulation that allows a wide range of charitable initiatives on behalf of religious organizations, on the governance of Catholic Church entities, which are submitted to the directives and authorizations of ecclesiastical authorities. Finally, it draws some conclusive remarks on the need to update and reform some administrative rules and praxis concerning the administration and finance of charitable institutions in Canon Law.
description: Stato, Chiese e pluralismo confessionale, 2018: 11 giugno
Enti ecclesiastici e Terzo settore. Annotazioni prospettiche
Creators: name: Dalla Torre, Giuseppe
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2018

description: SOMMARIO: 1. 1. Nuovi orizzonti - 2. Un caso positivo di secolarizzazione - 3. Codice del Terzo settore e iniziative caritative della comunità ecclesiale - 4. Opportunità aperte da un’alternativa - 5. L’azione caritativa tra diritto speciale e diritto comune. ABSTRACT: Except for the matter of the clergy sustenance, the current discipline of the Concordat on ecclesiastical institutions is still affected, in spite of everything, by the conditioning deriving from juridical schemes dating back in time, which sacrifice and make precarious their solidarity activities. The fall of the diffidence of the Italian legal system towards the initiatives between the State and the Market, and therefore the recent reform of the Third sector with the enhancement of the non-profit organization’s activities, represent a precious opportunity for the charitable initiatives of the ecclesial communities.
description: Stato, Chiese e pluralismo confessionale, 2018: 30 aprile