cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Dense outlier detection and open-set recognition based on training with noisy negative images
Creators: name: Bevandić, Petra
name: Krešo, Ivan
name: Oršić, Marin
name: Šegvić, Siniša
Publisher: name: arXiv
Year: 2021
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Deep convolutional models often produce inadequate predictions for inputs foreign to the training distribution. Consequently, the problem of detecting outlier images has recently been receiving a lot of attention. Unlike most previous work, we address this problem in the dense prediction context in order to be able to locate outlier objects in front of in-distribution background. Our approach is based on two reasonable assumptions. First, we assume that the inlier dataset is related to some narrow application field (e.g.~road driving). Second, we assume that there exists a general-purpose dataset which is much more diverse than the inlier dataset (e.g.~ImageNet-1k). We consider pixels from the general-purpose dataset as noisy negative training samples since most (but not all) of them are outliers. We encourage the model to recognize borders between known and unknown by pasting jittered negative patches over inlier training images. Our experiments target two dense open-set recognition benchmarks (WildDash 1 and Fishyscapes) and one dense open-set recognition dataset (StreetHazard). Extensive performance evaluation indicates competitive potential of the proposed approach.
description: Published in Image and Vision Computing
Investigation on Theileria lestoquardi infection among sheep and goats in Nyala, South Darfur State, Sudan
Creators: name: TM, Osman
name: AM, Ali
name: MO, Hussein
name: A, El Ghali
name: DA, Salih
Publisher: name: figshare
Year: 2017
Subjects: subject: 60801 Animal Behaviour
subject: FOS: Biological sciences
subject: 60802 Animal Cell and Molecular Biology
subject: 60803 Animal Developmental and Reproductive Biology
subject: 60804 Animal Immunology
subject: 60805 Animal Neurobiology
subject: 60806 Animal Physiological Ecology
subject: 60601 Animal Physiology - Biophysics
subject: 60602 Animal Physiology - Cell
subject: 60603 Animal Physiology - Systems
subject: 60807 Animal Structure and Function
subject: 60301 Animal Systematics and Taxonomy

description: This study was conducted in Nyala, South Darfur State, Sudan during August-September 2015 to study the seroprevalence of ovine and caprine theileriosis and to identify the tick infesting sheep and goats. For this purpose, total of 150 samples (ticks, blood smear and sera) were collected from sheep (n=61) and goats (n=89) of different age groups, breed and both sex. Three age groups were included: less than one-year-old, one-two years-old and more than two-year-old. Two diagnostic techniques were used, blood smears, and indirect fluorescent antibody test (IFAT). Out of 150 samples, 9 (6%) were positive for Theileria spp. piroplasms in blood smears, and 81 (54%) were positive for Theileria lestoquardi antibodies. Out of 61 sheep, 3 (4.9%) were positive for Theileria spp. piroplasms, and 25 (41%) were positive for T. lestoquardi antibodies. Out of 89 goats, 6 (6.7%) were positive for Theileria spp. piroplasms, and 56 (62.9%) were positive for T. lestoquardi antibodies. The highest prevalence of T. lestoquardi was recorded among sheep and goats more than two-year-old. Two genera and 4 species of ticks were infested sheep and goats. These included Rhipicephalus evertsi evertsi, R. s. sanguineus, Amblyomma variegatum and A. lepidum. The study concluded that the malignant ovine theileriosis is endemic in Nyala town.
Arvensic acids K and L, components of resin glycoside fraction from Convolvulus arvensis
Creators: name: Lu, Yun
name: He, Ye
name: Yang, Min
name: Fan, Bo-Yi
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Alkaline hydrolysis of the resin glycoside fraction of the whole plants of Convolvulus arvensis gave two new glycosidic acids, named arvensic acids K and L (1 and 2). Their structures were characterized on the basis of spectroscopic data as well as chemical evidence. They possessed a same pentasaccharide chain, composed of one D-fucose, three D-glucose and one L-rhamnose units. The aglycone of compound 1 was identified to be rarely existing 11S-hydroxyheptadecanoic acid, while compound 2 possessed 11S-hydroxyhexadecanoic acid as the aglycone. Their cytotoxic and anti-migration activities were also evaluated.
title: ADCO, Troisième cartulaire de Saint-Étienne de Dijon (XVIe), Cart. 23 (G 127), 310 folios, f. 00008
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2011
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Troisième cartulaire de Saint-Étienne de Dijon (XVIe), Archives départementales de la Côte-d'Or, Cart. 23 (G 127), 310 folios, f. 00008, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Troisième cartulaire de Saint-Étienne de Dijon (XVIe), Archives départementales de la Côte-d'Or, Cart. 23 (G 127), 310 folios, f. 00008, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
A comment on “Ab initio study: the potential energy curves and ro-vibrational spectrum of low-lying excited states of HCl+ cation”
Creators: name: Liu, Ya-Jun
name: Xin-Lu Cheng
name: Chen, Hua-Jun
name: Cheng, Jun-Xia
name: Song, Xiao-Shu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Inorganic Chemistry

description: Since the 2Π state in HCl+ is an inverted doublet, the energy of the 2Π1/2 state is higher than the 2Π3/2. Therefore, the larger value of intensity correspond to the transition of 2Π3/2. We calculated the Einstein A coefficients and radiation lifetimes for the A2Σ+-X2Π transition. Our results are in good agreement with the experimental data and theoretical values. Then the ro-vibrational line intensities of the 1-0 band were calculated for the 2Π3/2 and 2Π1/2 states of HCl+. Employing the RKR potential, the predicted band origins for Δν=1-0 are 2569.3 and 2568.55 cm-1 for 2Π3/2 and 2Π1/2, respectively.
Supplementary Material for: Sexually Dimorphic Epigenetic Regulation of Brain-Derived Neurotrophic Factor in Fetal Brain in the Valproic Acid Model of Autism Spectrum Disorder
Creators: name: Konopko, M.A.
name: Densmore, A.L.
name: Krueger, B.K.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Prenatal exposure to the antiepileptic, mood-stabilizing drug, valproic acid (VPA), increases the incidence of autism spectrum disorders (ASDs); in utero administration of VPA to pregnant rodents induces ASD-like behaviors such as repetitive, stereotyped activity, and decreased socialization. In both cases, males are more affected than females. We previously reported that VPA, administered to pregnant mice at gestational day 12.5, rapidly induces a transient, 6-fold increase in BDNF (brain-derived neurotrophic factor) protein and mRNA in the fetal brain. Here, we investigate sex differences in the induction of Bdnf expression by VPA as well as the underlying epigenetic mechanisms. We found no sex differences in the VPA stimulation of total brain Bdnf mRNA as indicated by probing for the BDNF protein coding sequence (exon 9); however, stimulation of individual transcripts containing two of the nine 5′-untranslated exons (5′UTEs) in Bdnf (exons 1 and 4) by VPA was greater in female fetal brains. These Bdnf transcripts have been associated with different cell types or subcellular compartments within neurons. Since VPA is a histone deacetylase inhibitor, covalent histone modifications at Bdnf 5′UTEs in the fetal brain were analyzed by chromatin immunoprecipitation. VPA increased the acetylation of multiple H3 and H4 lysine residues in the vicinity of exons 1, 2, 4, and 6; minimal differences between the sexes were observed. H3 lysine 4 trimethylation (H3K4me3) at those exons was also stimulated by VPA. Moreover, the VPA-induced increase in H3K4me3 at exons 1, 4, and 6 was significantly greater in females than in males, i.e., sexually dimorphic stimulation of H3K4me3 by VPA correlated with Bdnf transcripts containing exons 1 and 4, but not 6. Neither H3K27me3 nor cytosine methylation at any of the 117 CpGs in the vicinity of the transcription start sites of exons 1, 4, and 6 was affected by VPA. Thus, of the 6 epigenetic marks analyzed, only H3K4me3 can account for the sexually dimorphic expression of Bdnf transcripts induced by VPA in the fetal brain. Preferential expression of exon 1- and exon 4-Bdnf transcripts in females may contribute to sex differences in ASDs by protecting females from the adverse effects of genetic variants or environmental factors such as VPA on the developing brain.
Benford's law: what does it say on adversarial images?
Creators: name: Zago, João G.
name: Baldissera, Fabio L.
name: Antonelo, Eric A.
name: Saad, Rodrigo T.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Artificial Intelligence (cs.AI)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Convolutional neural networks (CNNs) are fragile to small perturbations in the input images. These networks are thus prone to malicious attacks that perturb the inputs to force a misclassification. Such slightly manipulated images aimed at deceiving the classifier are known as adversarial images. In this work, we investigate statistical differences between natural images and adversarial ones. More precisely, we show that employing a proper image transformation and for a class of adversarial attacks, the distribution of the leading digit of the pixels in adversarial images deviates from Benford's law. The stronger the attack, the more distant the resulting distribution is from Benford's law. Our analysis provides a detailed investigation of this new approach that can serve as a basis for alternative adversarial example detection methods that do not need to modify the original CNN classifier neither work on the raw high-dimensional pixels as features to defend against attacks.
Chemical diversity and anti-acne inducing bacterial potentials of essential oils from selected Elsholtzia species
Creators: name: Sopit Phetsang
name: Jukreera Panyakaew
name: Sunanta Wangkarn
name: Nopakarn Chandet
name: Angkhana Inta
name: Kittiwachana, Sila
name: Pyne, Stephen G.
name: Pitchaya Mungkornasawakul
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry

description: Essential oils from the aerial parts of four Elsholtzia species; Elsholtzia stachyodes, Elsholtzia communis, Elsholtzia griffithii and Elsholtzia beddomei were obtained by steam distillation and their chemical components were analysed by gas chromatography-mass spectrometry (GC-MS). Principle Component Analysis was used to identify the chemical variations in the essential oils from these plants, which could be categorised into two groups according to their main chemical components which are acylfuran derivatives and oxygenated monoterpenes. Additionally, the anti-acne inducing bacterial activity against Staphylococcus aureus and Staphylococcus epidermidis were evaluated. The oil from E. stachyodes was the most efficacious against the growth of S. aureus and S. epidermidis having MIC values of 0.78 and 1.56 μL/mL, respectively, and exhibited five times more effective than erythromycin (standard antibiotic).
Edge-state influence on high-order harmonic generation in topological nanoribbons
Creators: name: Jürß, Hannah
name: Bauer, Dieter
Publisher: name: arXiv
Year: 2021
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Atomic Physics (physics.atom-ph)
subject: Optics (physics.optics)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The high-order harmonic generation in finite topological nanoribbons is investigated using a tight-binding description. The ribbons consist of hexagons and are almost one-dimensional. Two edge states emerge at the short edges of the ribbon after a gap closure between valence and conduction band, indicating a topological phase transition. The energies of those edge states as functions of the tight-binding parameters display crossings and avoided crossings, which influence the high-harmonic spectra.
description: 8 pages, 7 figures
The complete mitochondrial genome of major malaria vector Anopheles anthropophagus (Diptera: Culicidae) in China
Creators: name: Liu, Wei-ping
name: Zhang, Pei-yi
name: Xu, Sui
name: Tang, Jian-xia
name: Zhou, Hua-yun
name: Li, Ju-lin
name: Wang, Dao-jin
name: Liu, Yuan-yuan
name: Fang, Qiang
name: Xia, Hui
name: Zhu, Guo-ding
name: Tao, Zhi-yong
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology
subject: Computational Biology

description: Anopheles anthropophagus (Xu and Feng 1975) is the major vector of malaria in Eastern and Southern China. The species An. anthropophagus is considered a synonym of An. lesteri (Baisas & Hu, 1936), although they differ in several key biological characteristics. Here, we report the complete mitochondrial genome of An. anthropophagus for the first time. The mitogenome of An. anthropophagus is a typical circular, double-stranded molecule with a total length of 15,413 base pairs, and contains 13 protein-coding genes, 22 transfer RNA genes, two ribosomal RNA genes, and an AT-rich control region. A phylogenetic analysis of the complete mitogenomes of 16 species of Anopheles (Culicidae) revealed that An. anthropophagus is closely related to An. sinensis (Wiedemann 1828), in the family Culicidae. The An. anthropophagus mitogenome provides new data for further taxonomic and phylogenetic studies of the genus Anopheles.
Benefits of time for self-repair in aphasia (Leaman & Archer, 2022)
Creators: name: Leaman, Marion C.
name: Archer, Brent
Publisher: name: ASHA journals
Year: 2022
Subjects: Neurology and neuromuscular diseases
Speech pathology
Speech production

description: Purpose: This study investigated the communicative benefits of self-repair during conversation for persons with aphasia (PWAs). Self-repair of trouble sources is an interactional priority that emphasizes autonomy and competence. Of equal importance, conversationalists desire to minimize silences and work together to ensure forward movement (progressivity) of conversation. Simultaneously achieving progressivity and self-repair is challenging in aphasia, and PWAs and their partners often make trade-off decisions between these two activities. Conversation-level aphasia interventions usually focus on supportive techniques that promote participation while maintaining progressivity, effectively favoring progressivity over self-repair. This study evaluates the benefits of an alternative approach that shifts the emphasis to self-repair, thereby highlighting potential trade-off costs of routinely forgoing self-repair to achieve progressivity.Method: Ten people with mild-to-moderate aphasia each held two conversations with two different partners. When trouble sources characterized by silent and/or filled pauses occurred, partners maintained a supportive and engaged stance, allowing PWAs time to self-repair. We analyzed language produced during these “edited turns” using three paradigms considering form, content, and use.Results: The data yielded 311 edited turns. For form, on average, each edited turn resulted in 3.72 words; for content, most edited turns contained autobiographical information; for use, approximately 40% of edited turns introduced new information, and 40% added to the ongoing topic. The remainder were either ambiguous or comments such as, “I can’t think of it.”Conclusions: When given engaged support and time to self-repair, PWAs contributed meaningful personal information to conversations for approximately 80% of edited turns. Importantly, self-repair often resulted in self-expression that directed the conversation, which is a communicative role critical for empowering agency and identity. This research opens a dialogue about benefits and limitations of approaches that prioritize either progressivity or self-repair and how to balance the two to optimize therapeutic benefits for each individual.
Supplemental Material S1. Collecting conversations post-training quiz for speech-language pathologist partners.
Supplemental Material S2. Partner session fidelity rating form.
Leaman, M. C., & Archer, B. (2022). “If you just stay with me and wait. . .you’ll get an idea of what I’m saying”: The communicative benefits of time for conversational self-repair for people with aphasia. American Journal of Speech-Language Pathology. Advance online publication. https://doi.org/10.1044/2022_AJSLP-21-00199
title: ADCO, Sixième cartulaire de Saint-Étienne de Dijon (1662), Cart. 30 (G 133), 441 folios, f. 591
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Sixième cartulaire de Saint-Étienne de Dijon (1662), Archives départementales de la Côte-d'Or, Cart. 30 (G 133), 441 folios, f. 591, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Sixième cartulaire de Saint-Étienne de Dijon (1662), Archives départementales de la Côte-d'Or, Cart. 30 (G 133), 441 folios, f. 591, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
CSC-Unet: A Novel Convolutional Sparse Coding Strategy Based Neural Network for Semantic Segmentation
Creators: name: Tang, Haitong
name: He, Shuang
name: Yang, Mengduo
name: Lu, Xia
name: Yu, Qin
name: Liu, Kaiyue
name: Yan, Hongjie
name: Wang, Nizhuan
Publisher: name: arXiv
Year: 2021
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Artificial Intelligence (cs.AI)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: It is a challenging task to accurately perform semantic segmentation due to the complexity of real picture scenes. Many semantic segmentation methods based on traditional deep learning insufficiently captured the semantic and appearance information of images, which put limit on their generality and robustness for various application scenes. In this paper, we proposed a novel strategy that reformulated the popularly-used convolution operation to multi-layer convolutional sparse coding block to ease the aforementioned deficiency. This strategy can be possibly used to significantly improve the segmentation performance of any semantic segmentation model that involves convolutional operations. To prove the effectiveness of our idea, we chose the widely-used U-Net model for the demonstration purpose, and we designed CSC-Unet model series based on U-Net. Through extensive analysis and experiments, we provided credible evidence showing that the multi-layer convolutional sparse coding block enables semantic segmentation model to converge faster, can extract finer semantic and appearance information of images, and improve the ability to recover spatial detail information. The best CSC-Unet model significantly outperforms the results of the original U-Net on three public datasets with different scenarios, i.e., 87.14% vs. 84.71% on DeepCrack dataset, 68.91% vs. 67.09% on Nuclei dataset, and 53.68% vs. 48.82% on CamVid dataset, respectively.
Mães Solo do Licuri: Resistência, Empoderamento e Emancipação?
Creators: name: Edmeire Oliveira Pires
name: De Faria Barbosa, Claudia
Publisher: name: Zenodo
Year: 2021
Subjects: mães solo- empoderamento- emancipação- resistência

description: Este artigo é parte de uma pesquisa mais ampla que objetiva analisar os processos sociais que envolvem a maternidade solo. Questiona-se: as mães solo de Souto Soares percebem as discriminações e opressões geradas pelos preconceitos decorrentes da estrutura patriarcal e machista em relação à maternagem sem o estabelecimento da relação conjugal? Ancorada na abordagem da história oral esta pesquisa encontra mulheres resilientes que perseguem suas emancipações, objetivando, acima de tudo, proporcionar uma vida segura e confortável para si e seus filhos. Mães Solo do Licuri: Resistência, Empoderamento e Emancipaçõ?
Salvia broussonetii Benth.: aroma profile and micromorphological analysis
Creators: name: Najar, Basma
name: Pistelli, Luisa
name: Cervelli, Claudio
name: Fico, Gelsomina
name: Giuliani, Claudia
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Hematology

description: The volatile profiles (VOC) and the essential oil (EO) composition from the aerial parts of Salvia broussonetii were analysed. Sesquiterpene hydrocarbons dominate the VOCs from leaves (95.7%) and flowers (67.6%), followed by monoterpene hydrocarbons (2.6 and 29.7%, respectively). The main common compounds are germacrene D, β-bourbonene, α-pinene, α-copaene and α-gurjunene, even if with divergent relative abundances. In the leaf EOs the sesquiterpenes prevail, even if not overwhelmingly (about 50.0%), followed by monoterpenes (23.0–35.0%) and by minor fractions of diterpene hydrocarbons and non-terpene derivates. The most abundant common compounds across the two sampling periods are α-pinene, β-pinene, isobornyl acetate, α-gurjenene, germacrene D and bifloratriene. A morphological characterisation of the trichomes responsible for the productivity in terpenes was also performed. Four different morphotypes were observed on the above ground organs of S. brussonetii: peltates and capitates of type II and III resulted the only producers of volatile substances.
Concurrent Active Learning in Autonomous Airborne Source Search: Dual Control for Exploration and Exploitation
Creators: name: Li, Zhongguo
name: Chen, Wen-Hua
name: Yang, Jun
Publisher: name: arXiv
Year: 2021
Subjects: subject: Systems and Control (eess.SY)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In this paper, a concurrent learning framework is developed for source search in an unknown environment using autonomous platforms equipped with onboard sensors. Distinct from the existing solutions that require significant computational power for Bayesian estimation and path planning, the proposed solution is computationally affordable for onboard processors. A new concept of concurrent learning using multiple parallel estimators is proposed to learn the operational environment and quantify estimation uncertainty. The search agent is empowered with dual capability of exploiting current estimated parameters to track the source and probing the environment to reduce the impacts of uncertainty, namely Concurrent Learning based Dual Control for Exploration and Exploitation (CL-DCEE). In this setting, the control action not only minimises the tracking error between future agent's position and estimated source location, but also the uncertainty of predicted estimation. More importantly, the rigorous proven properties such as the convergence of CL-DCEE algorithm are established under mild assumptions on noises, and the impact of noises on the search performance is examined. Simulation results are provided to validate the effectiveness of the proposed CL-DCEE algorithm. Compared with the information-theoretic approach, CL-DCEE not only guarantees convergence, but produces better search performance and consumes much less computational time.
Stevia rebaudiana targeting α-amylase: An in-vitro and in-silico mechanistic study
Creators: name: Ramit Singla
name: Singla, Navdeep
name: Jaitak, Vikas
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy

description: Diabetes mellitus (DM) is the fastest growing metabolic disorder in the world. Recently, more attention is paid to the study of natural products due to side effects of synthetic drugs. Stevia rebaudiana (Bertoni) is considered an encouraging starting point for the antidiabetic lead development. In the present study, the in vitro α-amylase inhibitory activity of the extracts of S. rebaudiana is investigated. In order to understand the molecular mechanism and future pharmacophore development, in silico study of secondary metabolites isolated from S. rebaudiana was carried out. Results indicated that water extract shows highest α-amylase inhibitory activity as compared to other extracts. Moreover, compound 20 (rebaudioside A) which has been previously reported and isolated from water extract showed the impressive binding profile with α-amylase. Therefore, our study suggests that S. rebaudiana could be used in the development of therapeutic drugs for the treatment of diabetes.
Brilliant blue R dye is capable of suppressing amyloid fibril formation of lysozyme
Creators: name: How, Su-Chun
name: Wei-Tse Hsu
name: Chia-Ping Tseng
name: Chun-Hsien Lo
name: Wei-Lung Chou
name: Wang, Steven S.-S.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Amyloid fibril formation is associated with an array of degenerative diseases. While no real cure is currently available, evidence suggests that suppression of amyloid fibrillogenesis is an effective strategy toward combating these diseases. Brilliant blue R (BBR), a disulfonated triphenylmethane compound, has been shown to interact with fibril-forming proteins but exert different effects on amyloid fibrillogenesis. These inconsistent findings prompted us to further evaluate BBR’s effect on the inhibition/suppresion of protein fibrillogenesis. Using 129-residue hen lysozyme, which shares high sequence homology to human lysozyme associated with hereditary non-neuropathic systemic amyloidosis, as a model, this study is aimed at thoroughly examining the influence of BBR on the in vitro protein fibrillogenesis. We first showed that BBR dose-dependently attenuated lysozyme fibril formation probably by affecting the fibril growth rate, with the value of IC50 determined to be ~4.39 μM. Next, we employed tryptophan fluorescence quenching method to determine the binding constant and number of binding site(s) associated with BBR-lysozyme binding. In addition, we further conducted molecular docking studies to gain a better understanding of the possible binding site(s) and interaction(s) between lysozyme and BBR. We believe some of the information and/or knowledge concerning the structure–function relationship associated with BBR’s suppressing activity obtained here can be applied for the future work in the subject matter related with the therapeutic strategies for amyloid diseases.
Additional file 1 of Relationship between gut microbiota dysbiosis and immune indicator in children with sepsis
Creators: name: Lin, Xia
name: Abdalla, Mohnad
name: Yang, Junjie
name: Liu, Lei
name: Fu, Yali
name: Zhang, Yanli
name: Yang, Shuchun
name: Yu, Han
name: Ge, Yongsheng
name: Zhang, Sufang
name: Kang, Guiyun
name: Dang, Wei
name: Jiang, Qin
name: Wang, Ying
name: Gai, Zhongtao
Publisher: name: figshare
Year: 2023
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1 Table 1: The damaged organs and bacterial isolation in the blood culture of all children with sepsis
Efficient GPU implementation of randomized SVD and its applications
Creators: name: Struski, Łukasz
name: Morkisz, Paweł
name: Spurek, Przemysław
name: Bernabeu, Samuel Rodriguez
name: Trzciński, Tomasz
Publisher: name: arXiv
Year: 2021
Subjects: subject: Machine Learning (cs.LG)
subject: Performance (cs.PF)
subject: FOS: Computer and information sciences

description: Matrix decompositions are ubiquitous in machine learning, including applications in dimensionality reduction, data compression and deep learning algorithms. Typical solutions for matrix decompositions have polynomial complexity which significantly increases their computational cost and time. In this work, we leverage efficient processing operations that can be run in parallel on modern Graphical Processing Units (GPUs), predominant computing architecture used e.g. in deep learning, to reduce the computational burden of computing matrix decompositions. More specifically, we reformulate the randomized decomposition problem to incorporate fast matrix multiplication operations (BLAS-3) as building blocks. We show that this formulation, combined with fast random number generators, allows to fully exploit the potential of parallel processing implemented in GPUs. Our extensive evaluation confirms the superiority of this approach over the competing methods and we release the results of this research as a part of the official CUDA implementation (https://docs.nvidia.com/cuda/cusolver/index.html).
Lettre de Antoine Gouan à Jean-François Séguier, 1783-08-16
Creators: name: Gouan, Antoine
name: Gouan, Antoine
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: Botanique

description: [fol. 208] Montpellier 16 août 1783.

Monsieur et cher ami,

Ne pouvant avoir le plaisir de vous voir, je m’en dédommage en partie en m’entretenant un instant avec vous et je crois que vous vous apercevrez comme moi que notre silence n’était déjà que trop long. M. Butini, médecin, fils du célèbre médecin de Genève, connu lui-même pour des ouvrages intéressants, membre de quelques académies, vous remettra cette lettre. Vous devez sentir le désir qu’il a de vous connaître par celui que vous avez inspiré à tant d’autres avant lui. Je souhaite qu’il vous trouve en bonne santé et que vous conserviez toujours un peu de part dans votre amitié à celui qui vous a voué toute la sienne.

 Gouan
Cité :
Pierre Butini, médecin de Genève. (1759-1807) Fils de Jean-Antoine Butini (1723-1810)
description: Source: [établissement de conservation] Nîmes, Bibliothèque Carré d'Art [cote] ms. 144, fol. 208
Anais do XV Encontro de Enfermeiros de Hospitais de Ensino do Estado de São Paulo - Tema Central: Protagonismo da Enfermagem no Enfrentamento da pandemia da Covid-19
Creators: name: Ieda Aparecida Carneiro
name: Balsanelli, Alexandre Pazetto
name: Blanes, Leila
name: De Macedo Motoyama, Caio Sussumu
Publisher: name: Zenodo
Year: 2022
Subjects: Enfermagem
Covid 19
Gerenciamento
Assistência
Ensino e pesquisa

description: Esta publicação possui os resumos dos trabalhos apresentados no XV Encontro de Enfermeiros de Hospitais de Ensino do Estado de São Paulo (ENFHESP). O ENFEHSP foi idealizado por profissionais da Universidade Estadual de Campinas - UNICAMP, a primeira edição ocorreu no ano de 1991. O evento é realizado a cada dois anos e tem como objetivo discutir temas de interesse dos hospitais de ensino, assim como estimular o desenvolvimento e divulgação de produções científicas, tecnológicas e culturais. Reúne e promove intercâmbio entre enfermeiros das áreas assistencial, de ensino, pesquisa, acadêmicos de enfermagem e representantes das instituições de Ensino da Saúde. Em 2021 a Diretoria de enfermagem do Hospital São Paulo (HU da Unifesp) e a Escola Paulista de Enfermagem da Unifesp foram os responsáveis pela promoção do XV ENFHESP. O tema central foi definido como “Protagonismo da Enfermagem no Enfrentamento da pandemia da Covid-19”. O evento foi 100% virtual, o que trouxe visibilidade nacional. As comissões trabalharam incansavelmente para garantir o sucesso do evento por meio do aprimoramento científico e a troca de experiências entre as instituições, fortalecendo sua relevância no cenário nacional.
Volumes of subset Minkowski sums and the Lyusternik region
Creators: name: Barthe, Franck
name: Madiman, Mokshay
Publisher: name: arXiv
Year: 2021
Subjects: subject: Combinatorics (math.CO)
subject: Metric Geometry (math.MG)
subject: FOS: Mathematics

description: We begin a systematic study of the region of possible values of the volumes of Minkowski subset sums of a collection of $M$ compact sets in $\mathbb{R}^d$, which we call the Lyusternik region, and make some first steps towards describing it. Our main result is that a fractional generalization of the Brunn-Minkowski-Lyusternik inequality conjectured by Bobkov et al. (2011) holds in dimension 1. Even though Fradelizi et al. (2016) showed that it fails in general dimension, we show that a variant does hold in any dimension.
Hydroxyethylamine derivatives as HIV-1 protease inhibitors: a predictive QSAR modelling study based on Monte Carlo optimization
Creators: name: S. Bhargava
name: N. Adhikari
name: S. A. Amin
name: K. Das
name: S. Gayen
name: T. Jha
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Application of HIV-1 protease inhibitors (as an anti-HIV regimen) may serve as an attractive strategy for anti-HIV drug development. Several investigations suggest that there is a crucial need to develop a novel protease inhibitor with higher potency and reduced toxicity. Monte Carlo optimized QSAR study was performed on 200 hydroxyethylamine derivatives with antiprotease activity. Twenty-one QSAR models with good statistical qualities were developed from three different splits with various combinations of SMILES and GRAPH based descriptors. The best models from different splits were selected on the basis of statistically validated characteristics of the test set and have the following statistical parameters: r2 = 0.806, Q2 = 0.788 (split 1); r2 = 0.842, Q2 = 0.826 (split 2); r2 = 0.774, Q2 = 0.755 (split 3). The structural attributes obtained from the best models were analysed to understand the structural requirements of the selected series for HIV-1 protease inhibitory activity. On the basis of obtained structural attributes, 11 new compounds were designed, out of which five compounds were found to have better activity than the best active compound in the series.
Additional file 2 of Relationship between gut microbiota dysbiosis and immune indicator in children with sepsis
Creators: name: Lin, Xia
name: Abdalla, Mohnad
name: Yang, Junjie
name: Liu, Lei
name: Fu, Yali
name: Zhang, Yanli
name: Yang, Shuchun
name: Yu, Han
name: Ge, Yongsheng
name: Zhang, Sufang
name: Kang, Guiyun
name: Dang, Wei
name: Jiang, Qin
name: Wang, Ying
name: Gai, Zhongtao
Publisher: name: figshare
Year: 2023
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 2 Table 2: Organ damage influencing the gut microbiome of children with sepsis
Digital Quantum Simulation of the Schwinger Model and Symmetry Protection with Trapped Ions
Creators: name: Nguyen, Nhung H.
name: Tran, Minh C.
name: Zhu, Yingyue
name: Green, Alaina M.
name: Alderete, C. Huerta
name: Davoudi, Zohreh
name: Linke, Norbert M.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Quantum Physics (quant-ph)
subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Tracking the dynamics of physical systems in real time is a prime application of digital quantum computers. Using a trapped-ion system with up to six qubits, we simulate the real-time dynamics of a lattice gauge theory in 1+1 dimensions, i.e., the lattice Schwinger model, and demonstrate non-perturbative effects such as pair creation for times much longer than previously accessible. We study the gate requirement of two formulations of the model using the Suzuki-Trotter product formula, as well as the trade-off between errors from the ordering of the Hamiltonian terms, the Trotter step size, and experimental imperfections. To mitigate experimental errors, a recent symmetry-protection protocol for suppressing coherent errors and a symmetry-inspired post-selection scheme are applied. This work demonstrates the integrated theoretical, algorithmic, and experimental approach that is essential for efficient simulation of lattice gauge theories and other complex physical systems.
The association between cement type and the subsequent risk of revision surgery in primary total hip replacement
Creators: name: Trela-Larsen, Lea
name: Sayers, Adrian
name: Blom, Ashley William
name: Webb, Jason Crispin John
name: Whitehouse, Michael Richard
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Background and purpose — To further improve the success of joint replacement surgery, attention needs to be paid to variations associated with improved or worsened outcomes. We investigated the association between the type of bone cement used and the risk of revision surgery after primary total hip replacement. Methods — We conducted a prospective study of data from the National Joint Registry for England and Wales between April 1, 2003 and December 31, 2013. 199,205 primary total hip replacements performed for osteoarthritis where bone cement was used were included. A multilevel over-dispersed piecewise Poisson model was used to estimate differences in the rate of revision by bone cement type adjusted for implant type, head size, age, sex, ASA grade, and surgical approach. Results — The rate of revision was higher in DePuy CMW3 medium viscosity with gentamicin (IRR 2.0, 95% CI 1.5–2.7) and DePuy SmartSet high viscosity plain (IRR 2.7, 95% CI 1.1–5.5), and lower in DePuy CMW1 high viscosity plain (IRR 0.44, 95% CI 0.19–0.89) bone cements compared with Heraeus Palacos high viscosity with gentamicin. Revision rates were similar between plain and antibiotic-loaded bone cement. Interpretation — The majority of bone cements performed similarly well, excluding DePuy SmartSet high viscosity and CMW3 high viscosity with gentamicin, which both had higher revision rates. We found no clear differences by viscosity or antibiotic content.
Resveratrol-based cinnamic ester hybrids: synthesis, characterization, and anti-inflammatory activity
Creators: name: Ban-Feng Ruan
name: Ge, Wei-Wei
name: Cheng, Hui-Jie
name: Xu, Hua-Jian
name: Li, Qing-Shan
name: Liu, Xin-Hua
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Twenty-three novel resveratrol-based cinnamic ester hybrids were designed and synthesized. All the compounds were evaluated for their anti-inflammatory activity using RAW264.7 cells. Among them, compound D15 was found to be the most potent one in inhibiting NO production in LPS-stimulated RAW264.7 cells. The further study indicated that compound D15 could suppress expression of proteins iNOS, COX-2, p-p65, and p-IκB LPS-induced. Immunofluorescence further revealed compound D15 could reduce activation p65 in nuclei. All the results indicated that the anti-inflammatory activity of title compound may partly due to its inhibitory effect on the NF-κB signaling pathway.
Electronic supplementary material for Biomechanical adaptations enable phoretic mite species to occupy distinct spatial niches on host burying beetles
Creators: name: Sun, Syuan-Jyun
name: Chen, Simon
name: Federle, Walter
name: Kilner, Rebecca M.
Publisher: name: The Royal Society
Year: 2024
Subjects: classificationCode: 310399
subject: Ecology not elsewhere classified
classificationCode: 310499
subject: Evolutionary biology not elsewhere classified
classificationCode: 320203
subject: Clinical microbiology

description: Niche theory predicts that ecologically similar species coexist by minimizing interspecific competition through niche partitioning. Therefore understanding the mechanisms of niche partitioning is essential for predicting interactions and coexistence between competing organisms. Here we study two phoretic mite species, Poecilochirus carabi and Macrocheles nataliae that coexist on the same host burying beetle Nicrophorus vespilloides and use it to ‘hitchhike’ between reproductive sites. Field observations revealed clear spatial partitioning between species in distinct host body parts. Poecilochirus carabi preferred the ventral side of the thorax, whereas M. nataliae were exclusively found ventrally at the hairy base of the abdomen. Experimental manipulations of mite density showed that each species preferred these body parts, largely regardless of the density of the other mite species on the host beetle. Force measurements indicated that this spatial distribution is mediated by biomechanical adaptations, because each mite species required more force to be removed from their preferred location on the beetle. While P. carabi attached with large adhesive pads to the smooth thorax cuticle, M. nataliae gripped abdominal setae with their chelicerae. Our results show that specialist biomechanical adaptations for attachment can mediate spatial niche partitioning among species sharing the same host.
Cross-Domain Deep Code Search with Meta Learning
Creators: name: Chai, Yitian
name: Zhang, Hongyu
name: Shen, Beijun
name: Gu, Xiaodong
Publisher: name: arXiv
Year: 2022
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: Recently, pre-trained programming language models such as CodeBERT have demonstrated substantial gains in code search. Despite showing great performance, they rely on the availability of large amounts of parallel data to fine-tune the semantic mappings between queries and code. This restricts their practicality in domain-specific languages with relatively scarce and expensive data. In this paper, we propose CroCS, a novel approach for domain-specific code search. CroCS employs a transfer learning framework where an initial program representation model is pre-trained on a large corpus of common programming languages (such as Java and Python) and is further adapted to domain-specific languages such as SQL and Solidity. Unlike cross-language CodeBERT, which is directly fine-tuned in the target language, CroCS adapts a few-shot meta-learning algorithm called MAML to learn the good initialization of model parameters, which can be best reused in a domain-specific language. We evaluate the proposed approach on two domain-specific languages, namely, SQL and Solidity, with model transferred from two widely used languages (Python and Java). Experimental results show that CDCS significantly outperforms conventional pre-trained code models that are directly fine-tuned in domain-specific languages, and it is particularly effective for scarce data.
description: Accepted by ICSE 2022 (The 44th International Conference on Software Engineering)
title: L'expérience du redoublement
title: enquête auprès d'une cohorte de jeunes concernés
titleType: Subtitle
title: L'expérience du redoublement
titleType: AlternativeTitle
Creators: name: Benghali Daeppen, Karine
Publisher: name: Unité de recherche pour le pilotage des systèmes pédagogiques
Year: 2011

description: Contient : partie 1 (74 p.) ; partie 2 (44 p.)
title: ADCO, Ordre cistercien : comptes (1403-1423) (11 H 1161), f. 00248
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: comptes
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Ordre cistercien : comptes (1403-1423), Archives départementales de la Côte-d'Or, (11 H 1161). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Ordre cistercien : comptes (1403-1423), Archives départementales de la Côte-d'Or, (11 H 1161), f. 00248, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/