cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: MRI-US Fusion Imaging In Rheumatoid Arthritis: Comparison Of Power Doppler With Contrast-Enhanced MRI.
Creators: name: Fischetti, Aldo
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Inflammation
subject: Arthritides
subject: Physics
subject: Experimental investigations
subject: Ultrasound-Power Doppler
subject: MR
subject: Ultrasound physics
subject: Musculoskeletal system
subject: MR physics

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: MRI with gadolinium is increasingly used to objectively evaluate disease activity and damage in patients with rheumatoid arthritis (RA), especially in clinical trials. The RAMRIS method is a standardized semi-quantitative score, which is used to...
Concomitant use of clopidogrel and statins and risk of major adverse cardiovascular events following coronary stent implantation: The clopidogrel-statin interaction
Creators: name: Schmidt, Morten
name: Bøtker, Hans E.
name: Kaltoft, Anne
name: Johansen, Martin B.
name: Maeng, Michael
name: Baron, John A.
name: Tilsted, Hans Henrik
name: Sørensen, Henrik Toft
name: Jensen, Lisette O.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: To examine whether CYP3A4-metabolizing statin use modified the association between clopidogrel use and major adverse cardiovascular events (MACE) after coronary stent implantation, using time-varying drug exposure ascertainment.
title: Lesions of the distal phalanx: Imaging overview
Creators: name: Vidoni , Alessandro
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Musculoskeletal bone
subject: Plain radiographic studies
subject: MR
subject: Education
subject: Education and training

description: Learning objectives Background Imaging findings OR Procedure Details Conclusion References Personal Information
description: Learning objectives: To review the radiological features of the different pathologies which may involve the distal phalanx of the...
Additional file 1 of Immunophenotyping of peripheral blood cells allows to discriminate MIS-C and Kawasaki disease
Creators: name: Castaldo, Alice
name: D’Anna, Carolina
name: Gelzo, Monica
name: Giannattasio, Antonietta
name: Maglione, Marco
name: Muzzica, Stefania
name: Raia, Maddalena
name: Scalia, Giulia
name: Tripodi, Lorella
name: Castaldo, Giuseppe
name: Tipo, Vincenzo
name: Grieco, Domenico
name: Grieco, Michela
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Figure S1. Gating strategy. A)Lymphocyte cells were gated by using CD45, and this gate was used to identifythe T helper (TH) cells (CD3+ and CD4+) and T cytotoxic (CD3+ and CD8+)lymphocytes. B) CD19 was used to identify B cells. Figure S2. Comparison of white blood cells (WBC) andplatelets number in controls (n=70), MIS-C (n=46) and KD (n=28) patients athospital admission. *p < 0.01; ***p < 0.0001. KD: Kawasaki disease;MIS-C: multisystem inflammatory syndrome in children. Figure S3. Comparison of granulocytes, lymphocytes andmonocytes, as percentage and absolute number, in controls (n=70), MIS-C (n=46)and KD (n=28) patients at hospital admission. *p < 0.01; **p < 0.001;***p < 0.0001. KD: Kawasaki disease; MIS-C: multisystem inflammatorysyndrome in children. Figure S4.Comparison of T, T helper and T cytotoxic lymphocytes, as percentage andabsolute number, in controls (n=70), MIS-C (n=46) and KD (n=28) patients at hospitaladmission. **p < 0.001; ***p < 0.0001. KD: Kawasaki disease; MIS-C:multisystem inflammatory syndrome in children. Figure S5. Comparison ofB lymphocytes, as percentage and absolute number, in controls (n=70), MIS-C(n=46) and KD (n=28) patients at hospital admission. ***p < 0.0001. KD:Kawasaki disease; MIS-C: multisystem inflammatory syndrome in children. Figure S6. PCA analysisdiscriminating KD and MIS-C groups. A: 2D score plot; B: 3D score plot; KD:Kawasaki disease; MIS-C: multisystem inflammatory syndrome in children; PC:principal component; PCA: principal component analysis. Figure S7.Predictive accuracies of models from 2 to 5 variables of multivariate ROC curvebased exploratory analysis. ROC: receiver operating characteristic.
title: Diagnostic approach to ultrasound of soft tissues masses in the hand and wrist
Creators: name: Png, Meng Ai
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Screening
subject: Ultrasound
subject: Extremities
subject: Musculoskeletal soft tissue
subject: Neoplasia

description: Learning objectives Background Imaging findings OR Procedure Details Conclusion References Personal Information
description: Learning objectives: 1. To illustrate the sonographic characteristics of soft tissue masses in the hand and wrist, and 2. Demonstrate the utility of ultrasonography in the diagnostic work-up of such masses In this pictorial review, we will outline a diagnostic approach...
Cyclophosphamide and 4-hydroxycyclophosphamide pharmacokinetics in patients with glomerulonephritis secondary to lupus and small vessel vasculitis
Creators: name: Brouwer, Kim L.R.
name: Goldstein, Joyce A.
name: La, Mary
name: Falk, Ronald J.
name: Frye, Reginald F.
name: Dooley, Mary Anne
name: Wang, Jinzhao
name: Bridges, Arlene S.
name: Blaisdell, Joyce
name: Joy, Melanie S.
name: Hogan, Susan L.
name: Hu, Yichun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Cyclophosphamide, the precursor to the active 4-hydroxycyclophosphamide, is used in active glomerulonephritis despite limited pharmacokinetics data. The pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide were evaluated. The influence of laboratory and pharmacogenomic covariates on pharmacokinetics was evaluated as a secondary aim.
Emergent Universe in the Braneworld Scenario
Creators: name: Heydarzade, Y.
name: Hadi, H.
name: Darabi, F.
name: Sheykhi, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: According to Padmanabhan's proposal, the difference between the surface degrees of freedom and the bulk degrees of freedom in a region of space may result in the acceleration of Universe expansion through the relation $ΔV/Δt = N_{\rm sur}-N_{\rm bulk}$ where $N_{\rm bulk}$ and $N_{\rm sur}$ are referred to the degrees of freedom related to the matter and energy content inside the bulk and surface area, respectively \cite{Pad1}. In this paper, we study the dynamical effect of the extrinsic geometrical embedding of an arbitrary four dimensional brane in a higher dimensional bulk space and investigate the corresponding degrees of freedom. Considering the modification of Friedmann equations arising from a general braneworld scenario, we obtain a correction term in Padmanabhan's relation, denoting the number of degrees of freedom related to the extrinsic geometry of the brane embedded in higher dimensional spacetime as $ΔV /Δt=N_{\rm sur}-N_{\rm bulk}-N_{\rm extr}$ where $N_{\rm extr}$ is referred to the degree of freedom related to the extrinsic geometry of the brane while $N_{\rm sur}$ and $N_{\rm bulk}$ are as well as before. Finally, we study the validity of the first and second laws of thermodynamics for this general braneworld scenario in the state of thermal equilibrium and in the presence of confined matter fields to the brane with the induced geometric matter fields.
description: 16 pages, Major revision
Pilot study of rosiglitazone as an in vivo probe of paclitaxel exposure: Short report
Creators: name: Hertz, Daniel L.
name: Rollins, Kristan
name: Walko, Christine M.
name: Herendeen, Jill
name: Hull, J. Heyward
name: Bridges, Arlene S.
name: Watkins, Paul B.
name: Dees, E. Claire
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: To evaluate the use of rosiglitazone and the erythromycin breath test (ERMBT), as probes of CYP2C8 and CYP3A4, respectively, to explain inter-individual variability in paclitaxel exposure.
title: CT-Perfusion (320-Detector Row Ct) of chondroid bone tumors: is it useful?
Creators: name: Hernandez, Javier
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Musculoskeletal bone
subject: Oncology
subject: CT-Quantitative
subject: Computer Applications-Detection, diagnosis
subject: Statistics
subject: Neoplasia

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: Benign and malignant cartilaginous tumors are very difficult to differentiate and represent a clinical, radiological and histological challenge. An accurate prediction of the grade ofchondrosarcoma before surgical removal could affect the type of...
title: Anfänger sind keine kleinen Experten
Creators: name: Hawelka, Birgit
Publisher: name: Zentrum für Hochschul- und Wissenschaftsdidaktik, Universität Regensburg
Year: 2023

description: Expert:innen und Noviz:innen denken anders. Der Beitrag beschreibt, worin sich die Denkweise unterscheidet und wie Studierende unterstützt werden können, Expertenwissen aufzubauen.
title: Application of Sonoelastography (SE) in the evaluation of various musculoskeletal pathologies.
Creators: name: Peter, Cynthia
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Athletic injuries
subject: Physics
subject: Ultrasound-Spectral Doppler
subject: Ultrasound
subject: Musculoskeletal soft tissue
subject: Musculoskeletal joint

description: Learning objectives Background Imaging findings OR Procedure Details Conclusion References Personal Information
description: Learning objectives: To appreciate the role of sonoelastography (SE) in the evaluation of various musculoskeletal...
title: Degenerative scoliosis imaging: Technic and key points
Creators: name: Felter, Adrien
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Education and training
subject: Myelography
subject: Imaging sequences
subject: Diagnostic procedure
subject: MR
subject: CT
subject: Conventional radiography
subject: Musculoskeletal spine

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: Degenerative scoliosis is a frequent spine disorder. It can be the evolution of an idiopathic adolescent scoliois or can appear in ederly age ( fig 1 ). It results from degeneration of disks, facet joints, ligaments and muscles. We present key...
Bollywoodboom in Deutschland
Creators: name: Welzk, Esther
Publisher: name: Südasien
Year: 2022

description: Nicht nur im politischen und im wirtschaftlichen Bereich erfährt Indien, zum neuen asiatischen Wirtschaftswunder hochstilisiert, immer mehr Beachtung. Auch die Bereiche Lifestyle und Unterhaltung stehen im Fokus der öffentlichen Faszination. Bollywood und Indien sind „in“. In europäischen und amerikanischen Tanzschulen lernt man zu tanzen wie die Stars des indischen Kinos. Die Mode hat einen indisch eingefärbten „Ethno-Stil“ für sich wiederentdeckt. Wellness-Angebote mit indischem Touch, Ayurveda und Yoga liegen voll im Trend. Im Internet sind eine Vielzahl von DVDs und CDs zu diesem Lebensbereich zu erstehen. Doch auch die vermehrt im deutschen Kino und Fernsehen laufenden indischen Filme rücken den Subkontinent zumindest stückweise in unser Blickfeld.
description: Südasien, Bd. 27/28 Nr. 4/1 2007/2008(2007): Theater und Film
title: Native anterior cruciate ligament (ACL) anatomy correlation with possible ACL grafts: Patellar tendon, quadriceps tendon, semitendinosus-gracilis
Creators: name: Augustinavicius, Vytautas
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Grafts
subject: Surgery
subject: MR
subject: Musculoskeletal joint

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: Anterior cruciate ligament reconstruction is one of the most common orthopaedic procedures with increasing frequency (1). The goal of anatomic anterior cruciate ligament reconstruction is to replicate native ACL anatomy as closely as possible...
title: Multimodality Imaging Approach to Hip Arthroplasty Complications
Creators: name: Naqvi, Syed
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Prostheses
subject: Complications
subject: MR
subject: CT
subject: Conventional radiography
subject: Musculoskeletal joint

description: Learning objectives Background Imaging findings OR Procedure Details Conclusion References Personal Information
description: Learning objectives: This pictorial essay will demonstrate the common complications post total hip arthroplasty. We broadly categorize them into Immediate post-operative complications. Medium to long term complications. The best imaging modality to assess the...
Implications of genome-wide association studies in cancer therapeutics
Creators: name: Mcleod, Howard L.
name: Patel, Jai N.
name: Innocenti, Federico
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Genome wide association studies (GWAS) provide an agnostic approach to identifying potential genetic variants associated with disease susceptibility, prognosis of survival and/or predictive of drug response. Although these techniques are costly and interpretation of study results is challenging, they do allow for a more unbiased interrogation of the entire genome, resulting in the discovery of novel genes and understanding of novel biological associations. This review will focus on the implications of GWAS in cancer therapy, in particular germ-line mutations, including findings from major GWAS which have identified predictive genetic loci for clinical outcome and/or toxicity. Lessons and challenges in cancer GWAS are also discussed, including the need for functional analysis and replication, as well as future perspectives for biological and clinical utility. Given the large heterogeneity in response to cancer therapeutics, novel methods of identifying mechanisms and biology of variable drug response and ultimately treatment individualization will be indispensable.
G2C2-III: Structural parameters for Galactic globular clusters in SDSS passbands
Creators: name: Vanderbeke, Joachim
name: De Propris, Roberto
name: De Rijcke, Sven
name: Baes, Maarten
name: West, Michael J.
name: Blakeslee, John P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We use our Galactic Globular Cluster Catalog (G2C2) photometry for 111 Galactic globular clusters (GC) in g and z, as well as r and i photometry for a subset of 60 GCs and u photometry for 22 GCs, to determine the structural parameters assuming King (1962) models. In general, the resulting core radii are in good comparison with the current literature values. However, our half-light radii are slightly lower than the literature. The concentrations (and therefore also the tidal radii) are poorly constrained mostly because of the limited radial extent of our imaging. Therefore, we extensively discuss the effects of a limited field-of-view on the derived parameters using mosaicked SDSS data, which do not suffer from this restriction. We also illustrate how red giant branch (RGB) stars in cluster cores can stochastically induce artificial peaks in the surface brightness profiles. The issues related to these bright stars are scrutinised based on both our photometry and simulated clusters. We also examine colour gradients and find that the strongest central colour gradients are caused by central RGB stars and thus not representative for the cluster light or colour distribution. We recover the known relation between the half-light radius and the Galactocentric distance in the g-band, but find a lower slope for redder filters. We did not find a correlation between the scatter on this relation and other cluster properties. We find tentative evidence for a correlation between the half-light radii and the [Fe/H], with metal-poor GCs being larger than metal-rich GCs. However, we conclude that this trend is caused by the position of the clusters in the Galaxy, with metal-rich clusters being more centrally located.
description: 17 pages, 23 figures, 3 tables. Accepted to MNRAS. The online appendix includes the structural parameters and the SB profile fits for all the sample clusters
In vivo assessment of the metabolic activity of CYP2D6 diplotypes and alleles
Creators: name: Corso, Steven
name: Olajide, Oludamilola
name: Irvin, William J.
name: Raab, Rachel
name: Snavely, Anna C.
name: Ibrahim, Joseph G.
name: Evans, James P.
name: McLeod, Howard L.
name: Schwartz, Garry
name: Desta, Zeruesenay
name: Peppercorn, Jeffrey M.
name: Hertz, Daniel L.
name: Walko, Christine M.
name: Weck, Karen E.
name: Flockhart, David A.
name: Carey, Lisa A.
name: Moore, Susan
name: Magrinat, Gustav
name: Carrizosa, Daniel R.
name: Anderson, Steven
name: Jones, David R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: A prospectively enrolled patient cohort was used to assess whether the prediction of CYP2D6 phenotype activity from genotype data could be improved by reclassification of diplotypes or alleles.
Additional file 1 of In silico designing of a novel epitope-based candidate vaccine against Streptococcus pneumoniae with introduction of a new domain of PepO as adjuvant
Creators: name: Bahadori, Zohreh
name: Shafaghi, Mona
name: Madanchi, Hamid
name: Ranjbar, Mohammad Mehdi
name: Shabani, Ali Akbar
name: Mousavi, Seyed Fazlollah
Publisher: name: figshare
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Fig. S1. TMHMM result for PhtD-C (A), PsaA (B), and PspC (C). The TMHMM plots (A, B, and C) show no existence of transmembrane helices. Fig. S2. SignalP 4.0 web-server output for the sequences of PsaA and PspC. The C-, S-, and Y-scores represent the predicted cleavage site value, the projected signal peptide value, and a combination of C-and S-scores, respectively. (A) The anticipated cleavage site of PsaA is located between positions 19 and 20. (B) In PspC, there is not any cleavage site. Fig. S3. Three-dimensional structures of proteins PhtD-C (A) and PspC (B). The structures were predicted by I-TASSER. Fig. S4. Validation of the refined tertiary structures. A and B show the results of ProSA web for PhtD-C and PspC, respectively. The a and b display Ramachandran plots of PhtD-C and PspC, respectively. Fig. S5. Three-dimensional structure of TLR agonist N-PepO. The structure of N-PepO was predicted and refined by I-TASSER and GalaxyRefine, respectively. Table S1. The results of validation before and after refinement. Ramachandran plot statistics from PROCHECK and Z-score from ProSA web server. Table S2. Prediction of linear B-cell epitopes from PhtD-C by LBTope, ABCpred, IEDB Emini tool, and Ellipro. Table S3. Prediction of linear B-cell epitopes from PsaA by LBTope, ABCpred, Emini, and Ellipro. Table S4. Prediction of linear B-cell epitopes from PspC by LBTope, ABCpred, Emini, and Ellipro. Table S5. Prediction of conformational epitopes from PhtD-C via Ellipro and Discotope. Table S6. Prediction of conformational epitopes from PsaA via Ellipro and Discotope. Table S7. Prediction of conformational epitopes from PspC via Ellipro and Discotope. Table S8. Prediction of MHCII epitopes from PhtD-C by IEDB and NetMHCIIpan. Table S9. Prediction of MHCII epitopes from PsaA by IEDB and NetMHCIIpan. Table S10. Prediction of MHCII epitopes from PspC by IEDB and NetMHCIIpan.
title: Neck muscle chart realized with fusion imaging technique (US-MRI) for botulinum - toxin treatment in cervical dystonia
Creators: name: De Marchi, Armanda
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Musculoskeletal system
subject: Head and neck
subject: Interventional non-vascular
subject: Ultrasound
subject: MR
subject: Experimental investigations
subject: Puncture
subject: Tissue characterisation
subject: Patterns of Care
subject: Motility

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: Primary cervical dystonia is the most common focal dystonia in adults [1] , characterized by sustained muscle contractions leading to repetitive involuntary stereotyped movement and/or abnormal posture. Botulinum toxin intramuscular injection is the...
The risk of cardiomyopathy in inherited epidermolysis bullosa
Creators: name: Fine, J. D.
name: Weiner, M.
name: Li, K. P.
name: Hall, M.
name: Suchindran, C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: BackgroundCase reports have suggested that cardiomyopathy may be a complication of recessive dystrophic epidermolysis bullosa (RDEB).ObjectiveTo determine the risk of congestive heart failure (CHF) or cardiomyopathy in each major EB subtype.MethodsThese data represent systematic case findings and data collection performed throughout the continental United States from 1986 through 2002, by the National Epidermolysis Bullosa Registry. Study design is cross-sectional (n = 3280) with a nested randomly sampled longitudinal subcohort (n = 450). Frequencies of CHF and cardiomyopathy were determined by patient self-reporting, medical histories and review of medical records. In those who died, death certificates were reviewed and histories obtained from surviving family. Cumulative risks were stratified by cause and EB subtype.ResultsCardiomyopathy was reported as early as within the first year of life. In patients having no other known risk factors for CHF or cardiomyopathy, the highest risk of cardiomyopathy was seen among patients with Hallopeau–Siemens RDEB (RDEB-HS), with a cumulative risk of 4·51% on or after age 20 years. The cumulative risk of cardiomyopathy was only 1·14% and 0·40% in non-Herlitz junctional EB (JEB) and non-Hallopeau–Siemens RDEB, respectively, and was not observed in any other EB subtype. When patients with coexistent chronic renal failure were included, the cumulative risk for RDEB-HS rose to 18·86% by age 35 years. About 30% of our patients affected with RDEB-HS died of CHF or cardiomyopathy, even those with no other known risk factors.ConclusionsCHF and cardiomyopathy are uncommon complications in both major RDEB subtypes and non-Herlitz JEB, and may be fatal.
メロディの覚えやすさに関する分析
Creators: name: 増田航
Publisher: name: Zenodo
Year: 2023
Subjects: 記憶課題
再認
メロディ記憶
catchy

description: メロディを形容する言葉に「キャッチー」がある.英英辞典には catchy は「a catchy tune or phrase is easy to remember」と説明されており、覚えやすさや思 い出しやすさに関する言葉であるとされている.しかし,どのようなメロディが 覚えやすい/思い出しやすいかは,明らかではない. 本研究では,メロディの「覚えやすさ」の定量化を目指し,メロディの特徴と 「覚えやすさ」の関係を明らかにすることを目的とする.我々は聴いたことのある 定型のパターンと,印象深さを生む定型外の要素のバランスがメロディの「覚え やすさ」には重要であり,前者に加えて後者が適度に入ることで,メロディの覚え やすさが向上するという仮説を立てた.後者の要素として裏拍,跳躍進行,ノン ダイアトニックに着目し,これらが含まれるメロディとこれらを意図的に削除し たメロディを両方聴いたときに,両者の覚えやすさに差が生まれるかを検証した. 実験は,記憶課題による再認実験として実施した.第一段階と第二段階にて構 成し,実験参加者は,第一段階はメロディの記憶段階として 12 個のメロディを聴 取し,第二段階を再認段階として ,12 個のメロディを聴取し,第一段階で聴いた かどうかを答えた. 実験結果より,裏拍からは,「符点八分音符+符点八分音符+八分音符」というリ ズムパターンを持つメロディは高い再認結果が得られ,このリズムパターンは「覚 えやすさ」に寄与していると考えられた.跳躍進行からは,5 度以上の上方向の 跳躍進行を持つメロディは,高い再認結果が得られたものが多く,我々の仮説を 支持する結果となった.また,跳躍進行の個数と加工前正答率に 0.61 の相関があり,これも我々の仮説を支持する結果と言えた.ノンダイアトニックからは,メ ロディのアクセントとしてよく用いられるブルーノートが,メロディの覚えやす さに寄与しているという検証結果が得られた.また,同音連打を多く用いたメロ ディは,いずれも高い再認結果が得られており,こちらもメロディの覚えやすさ に寄与していると言えた.
title: Rheumatoïd arthritis of the cervical spine
Creators: name: Chelli Bouaziz, Mouna
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Inflammation
subject: Technical aspects
subject: Plain radiographic studies
subject: MR
subject: CT
subject: Musculoskeletal spine

description: Learning objectives Background Imaging findings OR Procedure Details Conclusion References Personal Information
description: Learning objectives: Involvement of thecervicalspineinrheumatoid arthritiscan be essential regarding prognosis and mortality. Cervicalmyelopathy due to pannus formation and/or subluxation can be fatal. The aim of thisstudywas toillustrate the possible changes seen by...
Targeted inhibition of interleukin-6 with CNTO 328 sensitizes pre-clinical models of multiple myeloma to dexamethasone-mediated cell death
Creators: name: Hunsucker, Sally A.
name: Voorhees, Peter M.
name: Orlowski, Robert Z.
name: Kuhn, Deborah J.
name: Small, George W.
name: Nemeth, Jeffrey A.
name: Chen, Qing
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Interleukin (IL)-6-mediated signaling attenuates the anti-myeloma activity of glucocorticoids (GCs). We therefore sought to evaluate whether CNTO 328, an anti-IL-6 monoclonal antibody in clinical development, could enhance the apoptotic activity of dexamethasone (dex) in pre-clinical models of myeloma. CNTO 328 potently increased the cytotoxicity of dex in IL-6-dependent and –independent human myeloma cell lines (HMCLs), including a bortezomib-resistant HMCL. Isobologram analysis revealed that the CNTO 328/dex combination was highly synergistic. Addition of bortezomib to CNTO 328/dex further enhanced the cytotoxicity of the combination. Experiments with pharmacologic inhibitors revealed a role for the p44/42 mitogen-activated protein kinase pathway in IL-6-mediated GC resistance. Although CNTO 328 alone induced minimal cell death, it potentiated dex-mediated apoptosis, as evidenced by increased activation of caspases-8, -9, and -3, Annexin-V staining, and DNA fragmentation. The ability of CNTO 328 to sensitize HMCLs to dex-mediated apoptosis was preserved in the presence of human bone marrow stromal cells. Importantly, the increased activity of the combination was also seen in plasma cells from patients with GC-resistant myeloma. Taken together, our data provide a strong rationale for the clinical development of the CNTO 328/dex regimen for patients with myeloma.
Religionen in Südasien VIII: Purva-Mimamsa - wissenschaftlicher Diskurs zum vedischen Ritual
Creators: name: Lamers, Oliver
Publisher: name: Südasien
Year: 2022

description: Die Purva-Mimamsa („frühe“ Mimamsa, PM) zählt traditionell neben dem Vedanta, dem Samkhya, dem Yoga, dem Nyaya und dem Vaisheshika zu den sechs klassischen philosophischen Systemen des Hinduismus. Im Gegensatz zu diesen hat sie ihren Höhepunkt etliche Jahrhunderte früher erlebt, und ihre wahrnehmbaren Einflüsse auf das moderne religiöse Denken in Indien sind eher gering. Nichtsdestotrotz zählte und zählt sie in ihren verschiedenen Ausprägungen und historischen Epochen zu einem zentralen Übermittler und Verteidiger der vedischen Religiosität, die uns in den ältesten Schriften der Menschheit, dem Veda, überliefert ist.
description: Südasien, Bd. 27/28 Nr. 4/1 2007/2008(2007): Theater und Film
title:  Is the Word of God in ELF? New-Evangelization in Italian Immigration Contexts
Creators: name: Guido, Maria Grazia
Publisher: name: Roma TrE-Press
Year: 2016

description: Questo capitolo indaga i modi in cui il processo di “Nuova Evangelizzazione” (NE) nella Chiesa Cattolica si realizzi tramite ELF da parte del clero italiano, che offre assistenza spirituale e pratica agli immigrati. Uno studio di caso illustra come il discorso NE richieda agli immigrati di attivare la ‘sospensione del dubbio’, inducendoli in modo epistemico a credere che le rappresentazioni ‘metafisiche’ del mondo possano essere vere. Lo studio illustra anche la ‘flessibilità esperienziale’ che deonticamente costringe gli immigrati ad adattare la loro esperienza del mondo a tali costrutti controfattuali.
description: Intercultural Communication. New Perspectives from ELF
Exercise capacity and haemodynamics in patients with sickle cell disease with pulmonary hypertension treated with bosentan: results of the ASSET studies
Creators: name: Gladwin, Mark T.
name: Barst, Robyn J.
name: Swerdlow, Paul S.
name: Ataga, Kenneth I.
name: MacHado, Roberto F.
name: Mubarak, Kamal K.
name: Hildesheim, Mariana
name: Benza, Raymond L.
name: Naeije, Robert
name: Sood, Namita
name: Castro, Oswaldo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Doppler-defined pulmonary hypertension (PH) in sickle cell disease (SCD) is associated with 40% mortality at 40 months.
Large-N ground state of the Lieb-Liniger model and Yang-Mills theory on a two-sphere
Creators: name: Flassig, Daniel
name: Franca, Andre
name: Pritzel, Alexander
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We derive the large particle number limit of the Bethe equations for the ground state of the attractive one-dimensional Bose gas (Lieb-Liniger model) on a ring and solve it for arbitrary coupling. We show that the ground state of this system can be mapped to the large-N saddle point of Euclidean Yang-Mills theory on a two-sphere with a U(N) gauge group, and the phase transition that interpolates between the homogeneous and solitonic regime is dual to the Douglas-Kazakov confimenent-deconfinement phase transition.
description: 11 pages, 3 figures; added references
Additional file 1 of Assessing the impact of non-pharmaceutical interventions (NPIs) and BCG vaccine cross-protection in the transmission dynamics of SARS-CoV-2 in eastern Africa
Creators: name: Kilonzo, Chelsea Mbeke
name: Wamalwa, Mark
name: Whegang, Solange Youdom
name: Tonnang, Henri E. Z.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Table S1. Country-level percentage coverage of Bacillus Calmette–Guérin (BCG) vaccination in 2019, by age group. Table S2. Country-level dates of implementation of non-pharmaceutical interventions. Figure S1. Schematic overview of the Imperial College London (ICL) model adopted in this study [11]. Figure S2. Country-level estimates of infections, deaths and Rt in Ethiopia. Scenarios: A) The population is not BCG vaccinates, homogenous and not structured by age; B) BCG vaccinated population aged 39 years and below; C) BCG vaccinated population aged 40 years and above. Top: daily number of infections, brown bars are reported infections, blue bands are predicted infections, dark blue 50% credible interval (CI), light blue 95% CI. Bottom-left: daily number of deaths, brown bars are reported deaths, blue bands are predicted deaths. Bottom-right: time-varying reproduction number (Rt), dark-green 50% CI, light-green 95% CI. Figure S3. Country-level estimates of infections, deaths and Rt in Kenya. Scenarios: A) The population is not BCG vaccinates, homogenous and not structured by age; B) BCG vaccinated population aged 39 years and below; C) BCG vaccinated population aged 40 years and above. Top: daily number of infections, brown bars are reported infections, blue bands are predicted infections, dark blue 50% credible interval (CI), light blue 95% CI. Bottom-left: daily number of deaths, brown bars are reported deaths, blue bands are predicted deaths. Bottom-right: time-varying reproduction number (Rt), dark-green 50% CI, light-green 95% CI.
Epidemic Spreading in Random Rectangular Networks
Creators: name: Estrada, Ernesto
name: Meloni, Sandro
name: Sheerin, Matthew
name: Moreno, Yamir
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: The use of network theory to model disease propagation on populations introduces important elements of reality to the classical epidemiological models. The use of random geometric graphs (RGG) is one of such network models that allows for the consideration of spatial properties on disease propagation. In certain real-world scenarios -like in the analysis of a disease propagating through plants- the shape of the plots and fields where the host of the disease is located may play a fundamental role on the propagation dynamics. Here we consider a generalization of the RGG to account for the variation of the shape of the plots/fields where the hosts of a disease are allocated. We consider a disease propagation taking place on the nodes of a random rectangular graph (RRG) and we consider a lower bound for the epidemic threshold of a Susceptible-Infected-Susceptible (SIS) or Susceptible-Infected-Recovered (SIR) model on these networks. Using extensive numerical simulations and based on our analytical results we conclude that (ceteris paribus) the elongation of the plot/field in which the nodes are distributed makes the network more resilient to the propagation of a disease due to the fact that the epidemic threshold increases with the elongation of the rectangle. These results agree with accumulated empirical evidence and simulation results about the propagation of diseases on plants in plots/fields of the same area and different shapes.
description: Version 4, 13 pages, 6 figures, 44 refs
Reproductive history, hormone replacement, and incidence of venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology: Lifetime Oestrogen Exposure and Venous Thromboembolism
Creators: name: White, Richard H.
name: Cushman, Mary
name: Heckbert, Susan R.
name: Ohira, Tetsuya
name: Folsom, Aaron R.
name: Rosamond, Wayne D.
name: Hannan, Peter J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Numerous studies have established that hormone replacement therapy increases the risk of venous thromboembolism (VTE), but an association of endogenous estrogen exposure with the incidence of VTE is not fully established. Using a prospective design combining the Atherosclerosis Risk in Communities and the Cardiovascular Health Study cohort, we studied the 12-year risk of VTE in relation to hormone replacement therapy use, age at menopause, parity number, and type of menopause in 8,236 post-menopausal women. There were no significant associations of age at menopause, parity number, or type of menopause with incidence of VTE. Women currently using hormone replacement had a 1.6-times higher multivariate-adjusted rate ratio (RR) of VTE compared with those without hormone use in the time-dependent model (RR=1.60, 95% CI, 1.06-2.36; Population attributable fraction=6.7%, 95%CI, 1.0-10.3). When we excluded women with 1-year or more duration of hormone therapy at baseline, the associations was stronger (RR=2.02, 95%CI, 1.31-3.12). The multivariate-adjusted RRs of VTE for current users tended to be higher in those with idiopathic VTE (RR=2.40, 95%CI, 1.40-4.12) than those with secondary VTE (RR=1.08, 95%CI, 0.63-1.85). Hormone replacement therapy is associated with increased risk of VTE, but reproductive history markers of endogenous estrogen exposure were not associated with VTE.
title: Yes we can (perform these ct-guided procedures)
Creators: name: Diez Renovales, Fernando
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Neoplasia
subject: Infection
subject: Abscess
subject: Biopsy
subject: CT
subject: Musculoskeletal spine
subject: Musculoskeletal bone
subject: Interventional non-vascular

description: Learning objectives Background Imaging findings OR Procedure Details Conclusion References Personal Information
description: Learning objectives: To describe the appropriate indications, contraindications, and general technique to perform same basic interventional CT procedures in the skeletal system. To know the potential complications and how to avoid...
Südasienwissenschaften in Berlin
Creators: name: Framke, Maria
Publisher: name: Südasien
Year: 2022

description: Die Region Südasien erfuhr in den letzten Jahren seitens der deutschen Politik und Wirtschaft sowie in den Medien einen erheblichen Bedeutungszuwachs. Nicht erst seit dem Besuch der Bundeskanzlerin Angela Merkel im Oktober 2007 in Indien wird dem Subkontinent, und dabei insbesondere indien, eine Zukunft als neue Weltmacht des 21. Jahrhunderts attestiert. Forderungen wurden und werden laut, an diesem Aufstieg auch von deutscher Seite aus zu partizipieren. Im scharfen Gegensatz zu dieser Wahrnehmung der gestiegenen globalen Bedeutung Südasiens steht die gegenwärtige Hochschulpolitik. Sie nimmt diese Entwicklung kaum wahr und ist mancherorts verantwortlich für die Schließung südasienkundlicher Fächer. Jüngstes Beispiel hierfür ist Berlin.
description: Südasien, Bd. 27/28 Nr. 4/1 2007/2008(2007): Theater und Film
Kino als Agens sozialen Wandels
Creators: name: Hafner, Annemarie
Publisher: name: Südasien
Year: 2022

description: Als das Kino zu Beginn des 20. Jahrhunderts in Indien Fuß fasste, hatte die britische Kolonialherrschaft der einheimischen Kultur bereits eine neue Dimension verliehen. Das Kino fand eine Situation vor, die einerseits indische Intellektuelle veranlasste, sich westliche Denkweisen anzueignen, und sie andererseits dazu bewog, ihre eigene Identität zu behaupten. Filmemacher blieben davon nicht unberührt. Sie griffen mit ihren Werken in nicht zu unterschätzendem Maße in den Prozess des Kulturwandels und der Kultursynthese ein.
description: Südasien, Bd. 27/28 Nr. 4/1 2007/2008(2007): Theater und Film
Blockade of interleukin-6 signalling with siltuximab enhances melphalan cytotoxicity in preclinical models of multiple myeloma
Creators: name: Hunsucker, Sally A.
name: Kuhn, Deborah J.
name: Orlowski, Robert Z.
name: Magarotto, Valeria
name: Cornfeld, Mark
name: Wang, Michael
name: Weber, Donna M.
name: Kornblau, Steven M.
name: Nemeth, Jeffrey A.
name: Thomas, Sheeba K.
name: Shah, Jatin J.
name: Voorhees, Peter M.
name: Xie, Hong
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Signalling through the interleukin (IL)-6 pathway induces proliferation and drug resistance of multiple myeloma cells. We therefore sought to determine whether the IL-6-neutralizing monoclonal antibody siltuximab, formerly CNTO 328, could enhance the activity of melphalan, and to examine some of the mechanisms underlying this interaction. Siltuximab increased the cytotoxicity of melphalan in KAS-6/1, INA-6, ANBL-6, and RPMI 8226 human myeloma cell lines (HMCLs) in an additive-to-synergistic manner, and sensitized resistant RPMI 8226.LR5 cells to melphalan. These anti-proliferative effects were accompanied by enhanced activation of drug-specific apoptosis in HMCLs grown in suspension, and in HMCLs co-cultured with a human-derived stromal cell line. Siltuximab with melphalan enhanced activation of caspase-8, caspase-9, and the downstream effector caspase-3 compared with either of the single agents. This increased induction of cell death occurred in association with enhanced Bak activation. Neutralization of IL-6 also suppressed signalling through the phosphoinositide 3-kinase/Akt pathway, as evidenced by decreased phosphorylation of Akt, p70 S6 kinase and 4E-BP1. Importantly, the siltuximab/melphalan regimen demonstrated enhanced anti-proliferative effects against primary plasma cells derived from patients with myeloma, monoclonal gammopathy of undetermined significance, and amyloidosis. These studies provide a rationale for translation of siltuximab into the clinic in combination with melphalan-based therapies.
Merkels neuer Kurs in der Asienpolitik
Creators: name: Hansen, Sven
Publisher: name: Südasien
Year: 2022

description: Unmittelbar vor ihrer ersten Indien-Reise als Bundeskanzlerin hat Angela Merkel auf einem Asienkongress der CDU/CSU-Bundestagsfraktion einen politischen Spagat zwischen den asiatischen Riesen Indien und China gewagt. "Indien als Demokratie hat eine sehr gute Perspektive. Wir als Europäer haben alle Chancen dort. Wir müssen uns nur engagieren", sagte Merkel vor 600 Teilnehmern beim ersten Asienkongress der Unionsparteien am 26. Oktober in Berlin. Gleichzeitig lobte die Kanzlerin die Regierung in Peking: „Ohne Chinas Engagement wäre die Eindämmung des nordkoreanischen Atomprogramms nicht möglich gewesen. Das hatten wir so nicht erwartet.“ Merkels neuer Kurs wird von einem Asien-Strategiepapier der Unionsfraktion gestützt.
description: Südasien, Bd. 27/28 Nr. 4/1 2007/2008(2007): Theater und Film
Intravascular inhibition of factor VIIa and the analogue NN1731 by antithrombin
Creators: name: Pelzer, Hermann
name: Nichols, Timothy C.
name: Agersø, Henrik
name: Persson, Egon
name: Ezban, Mirella
name: Petersen, Lars C.
name: Karpf, Ditte M.
name: Hermit, Mette B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: N1731 is a recombinant activated factor VII (rFVIIa) analogue with increased intrinsic activity. This also applies to its reactivity towards antithrombin (AT), the role of which was investigated in a pharmacokinetic (PK) study. NN1731 or rFVIIa was administered to normal and haemophilia A dogs and elimination was measured by FVIIa clot activity, FVIIa- and FVIIa-AT antigen. In vitro AT complex formation was studied in canine plasma spiked with NN1731 or rFVIIa. Based on FVIIa antigen concentrations, PK profiles in normal and haemophilia A dogs were similar for NN1731 and rFVIIa with antigen half lives, t½ ≈ 1·8 h. In contrast, PK profiles based on activity measurements were distinctly different. NN1731 induced a strong, short lasting (t½ ≈ 0·5 h) pro-coagulant response, whereas rFVIIa induced a lower, longer lasting (t½ ≈ 1·1 h) response. Western Blot and FVIIa-AT antigen analysis demonstrated in vivo AT complex formation that accounted for these divergences. AT complex formation with FVIIa or NN1731 in vitro in canine plasma was considerably slower than the in vivo reaction. The results suggest that in vivo inhibition by AT contributes significantly to define drug duration in haemophilia treatment with rFVIIa and in particular with the NN1731 analogue.
MYH9 and APOL1 are both associated with sickle cell disease nephropathy
Creators: name: Ashley-Koch, Allison E.
name: Jonassaint, Jude C.
name: de Castro, Laura M.
name: Orringer, Eugene P.
name: Soldano, Karen
name: Telen, Marilyn J.
name: Okocha, Emmanuel C.
name: Eckman, James R.
name: Garrett, Melanie E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Renal failure occurs in 5–18% of sickle cell disease (SCD) patients and is associated with early mortality. At risk SCD patients cannot be identified prior to the appearance of proteinuria and the pathobiology is not well understood. The MYH9 and APOL1 genes have been associated with risk for focal segmental glomerulosclerosis and end-stage renal disease in African Americans.
Access Control for IoT: Problems and Solutions in the Smart Home
Creators: name: AHMAD, TAHIR
Publisher: name: Universit� degli studi di Genova
Year: 2020

description: The Internet of Things (IoT) is receiving considerable amount of attention from both industry and academia due to the business models that it enables and the radical changes it introduced in the way people interact with technology. The widespread adaption of IoT in our everyday life generates new security and privacy challenges. In this thesis, we focus on "access control in IoT": one of the key security services that ensures the correct functioning of the entire IoT system. We highlight the key differences with access control in traditional systems (such as databases, operating systems, or web services) and describe a set of requirements that any access control system for IoT should fulfill. We demonstrate that the requirements are adaptable to a wide range of IoT use case scenarios by validating the requirements for access control elicited when analyzing the smart lock system as sample use case from smart home scenario. We also utilize the CAP theorem for reasoning about access control systems designed for the IoT. We introduce MQTT Security Assistant (MQTTSA), a tool that automatically detects misconfigurations in MQTT-based IoT deployments. To assist IoT system developers, MQTTSA produces a report outlining detected vulnerabilities, together with (high level) hints and code snippets to implement adequate mitigations. The effectiveness of the tool is assessed by a thorough experimental evaluation. Then, we propose a lazy approach to Access Control as a Service (ACaaS) that allows the specification and management of policies independently of the Cloud Service Providers (CSPs) while leveraging its enforcement mechanisms. We demonstrate the approach by investigating (also experimentally) alternative deployments in the IoT platform offered by Amazon Web Services on a realistic smart lock solution.
Refining the value of secretory phospholipase A2 as a predictor of acute chest syndrome in sickle cell disease: results of a feasibility study (PROACTIVE)
Creators: name: Roseff, Susan D.
name: McMahon, Lillian E.C.
name: Iyer, Rathi V.
name: Onyekwere, Onyinye
name: Labotka, Richard J.
name: Ataga, Kenneth I.
name: Bellevue, Rita
name: Castro, Oswaldo L.
name: Wager, Carrie G.
name: Miller, Robin
name: Okam, Maureen
name: Miller, Scott T.
name: Smith-Whitley, Kim
name: Lane, Peter A.
name: Hsu, Lewis L.
name: Styles, Lori
name: Thompson, Alexis A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Acute chest syndrome (ACS) is defined as fever, respiratory symptoms and a new pulmonary infiltrate in an individual with sickle cell disease (SCD). Nearly half of ACS episodes occur in SCD patients already hospitalized, potentially permitting pre-emptive therapy in high-risk patients. Simple transfusion of red blood cells may abort ACS if given to patients hospitalized for pain who develop fever and elevated levels of secretory phospholipase A2 (sPLA2). In a feasibility study (PROACTIVE; ClinicalTrials.gov NCT00951808), patients hospitalized for pain who developed fever and elevated sPLA2 were eligible for randomization to transfusion or observation; all others were enrolled in an observational arm. Of 237 enrolled, only 10 were randomized; one of the four to receive transfusion had delayed treatment. Of 233 subjects receiving standard care, 22 developed ACS. A threshold level of sPLA2 ≥ 48 ng/ml gave optimal sensitivity (73%), specificity (71%) and accuracy (71%), but a positive predictive value of only 24%. The predictive value of sPLA2 was improved in adults and patients with chest or back pain, lower haemoglobin concentration and higher white blood cell counts; and those receiving less than two-thirds maintenance fluids. The hurdles identified in PROACTIVE should facilitate design of a larger, definitive, phase 3 randomized controlled trial.