cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Similarities and Differences in Correlates and Trends in Prescription Stimulant and Prescription Opioid Misuse Among College Students
Creators: name: Murray, Julie
Publisher: name: Utah State University
Year: 2023

description: When used as medically intended, prescription opioid and stimulant medications can have therapeutic benefits. Misuse of these medications, however, presents significant health risks, including increased risk of death and injury. Young adults, ages 18 to 25, have the highest rates of misuse of prescription opioids and stimulants nationally and within this age group, college students may be particularly at risk. This two-study dissertation explored factors related to prescription opioid and prescription stimulant misuse in college students in order to assess similarities and differences in correlates and trends.
Study #1 assessed for similarities and differences in correlates of prescription opioid misuse and prescription stimulant misuse, and built predictive models of prescription opioid misuse and prescription stimulant misuse. Study #2 examined the relationship between perceived risk of prescription misuse and engagement in misuse of each type of prescription. Additionally, study #2 examined initial motives for misuse and initial source of misused medication for prescription opioid and prescription stimulant misuse. Results from study #1 demonstrated some variation in predictors used for optimized prediction of prescription opioid and stimulant misuse. Results from study #2 revealed that higher perceived risk of prescription misuse is related to lower engagement in prescription opioid and prescription stimulant misuse. Additionally, there was a significant relationship between initial motive for misuse and initial source of misused medication for prescription opioids, such that participants who engaged in prescription opioid misuse for the first time in order to relieve physical pain were most likely to obtain the prescription opioid medication misused from their own prescription (i.e., leftover from an old prescription, taking prescription in a way other than how it was prescribed). Implications, limitations, and future directions of both studies were discussed.
Vanilloid receptor TRPV1-positive sensory afferents in the mouse ankle and knee joints
Creators: name: Cho, Won Gil
name: Valtschanoff, Juli G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: TRPV1, a cation channel on sensory nerves sensitive to heat and capsaicin, plays an important role in the transduction of noxious stimuli to the spinal cord. It is expressed by neurons in dorsal root ganglia (DRG) that may also express neuropeptides, which are important for the development of inflammation. Mice with genetic deletion of TRPV1 have been used to study the involvement of this receptor in the mediation of pain and inflammation in animal models of arthritis. However, the expression of TRPV1 in the mouse articular afferents has not been studied. We here provide numerical data on expression of TRPV1 in an identified population of sensory afferents to the mouse L3–L5 DRG that innervate joints, in comparison with that from bladder and skin. A combination of tracing and immunocytochemistry revealed that TRPV1-positive fibers innervate the mouse knee and ankle. At the level of DRG, ~40% of articular afferents from these joints express TRPV1 and the majority of them are peptidergic, as revealed by simultaneous immunostaining for the neuropeptide calcitonin gene-related peptide. These findings are consistent with the idea that activation of TRPV1 in peripheral axons of joint afferents may mediate the synovial release of neuropeptides in arthritis.
Neural activation deficits in a mouse genetic model of NMDA receptor hypofunction in tests of social aggression and swim stress
Creators: name: Koller, Beverly H.
name: Duncan, Gary E.
name: Farrington, Joseph S.
name: Inada, Ken
name: Moy, Sheryl S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Mice with reduced expression of the NR1 subunit of the NMDA receptor (NR1 hypomorphic mice) display altered behavioral phenotypes that may relate to behavioral characteristics of schizophrenia. Altered phenotypes in the NR1 hypomorphs include marked deficits in species-typical behavioral interactions in tests of social aggression and social affiliation. To gain insight into neuroanatomical circuits disrupted by reduced NMDA receptor function, the present work compared regional brain activation in NR1 hypomorphic mice and their wild type controls after a resident-intruder test. Induction of Fos protein was used as an index of neuronal activation. Wild type mice exhibited robust induction of Fos in select brain regions, including specific nuclei of the hypothalamus and amygdala, lateral septum, and widespread regions of the cerebral cortex. Although the behavioral patterns were different for male and female mice, neuroanatomical patterns of Fos induction were remarkably similar for the two sexes. To determine socially specific components of Fos induction by the resident-intruder test, responses were compared for mice assessed in a test of general arousal and stress involving forced swim. Some common brain regions were activated by both tests but regionally specific differences were also found. The NR1 hypomorphic mice tested in the resident-intruder procedure displayed distinctly different behavioral interactions compared to the wild type mice and exhibited a significantly blunted Fos response in almost all brain regions. The mutant mice also exhibited reduced Fos in response to swim stress in specific brain regions. These data suggest that the NR1 hypomorphic mice have functional activation deficits in response to social challenge and swim stress.
Development of novel bio-based building blocks and their application in organic synthesis and materials science
Creators: name: VITALI FORCONESI, GABRIELLA
Publisher: name: Universit� degli studi di Genova
Year: 2020

description: In the progression of modern society, the inevitable exhaustion of fossil resources becomes an increasingly concerning matter. These resources are not only the basis of the energy production of the world but also the precursor for many important platform chemicals. Therefore, development of green and renewable alternatives to the chemicals used in the current industry has become necessary. Within this context, the aim of the present thesis was the development of new efficient methodologies for obtaining high added-value products starting from biomass, a renewable source. The bio-based building blocks obtained were subsequently employed for the synthesis of polyfunctionalized chemicals and of polymers. The first part of the thesis focuses on the utilization of a bio-based meso diol for the synthesis of sugar derived structures, through the coupling of biocatalysis and multicomponent reaction (MCRs). These two different approaches are able to satisfy the requirements of an ideal approach, regarding selectivity (stereocontrol), efficiency and sustainability and their union with renewable feedstocks in a single integrated general strategy represents a powerful tool to achieve a sustainable synthesis. In particular, the work focused on the synthetic elaboration of the chiral molecules obtained through enzymatic desymmetrization to give enantiomerically pure building blocks to be used in diastereoselective Passerini reactions. In order to establish the synthetic usefulness of this new method, we demonstrated its application to the diversity-oriented synthesis of chiral, bio-based, oxygen heterocycles and to the target-oriented synthesis of Bengamides, a wide family of natural products of marine origin. The second part of the thesis is dedicated to the synthesis of a lactam- based monomer derived from bio-based starting materials and its subsequent polymerization. The project involved the synthesis and polymerization of 3-methylene-2-piperidone (3M2Pip) monomers, targeting the synthesis of well-defined hydroxyl end functional P(3M2Pip), i.e. HO-P(3M2Pip). Once obtained end-functionalized 3M2Pip-based polymers we will use them as a macro-initiator for the synthesis of degradable polyester second blocks, applicable in drug delivery polymer materials.
Combining models and observations for a more inclusive science with the Vera C. Rubin Observatory
Creators: name: Ustamujic, Sabina
name: Bonito, Rosaria
name: Venuti, Laura
Publisher: name: Zenodo
Year: 2022

description: The study of Young Stellar Objects (YSOs) and their variability (related to e.g. accretion, flares, rotation …) is one of the scientific topics that will take advantage of the Vera C. Rubin Observatory Legacy Survey of Space and Time (LSST) in the context of the Transients and Variable Stars (TVS) Science Collaboration (SC). In order to support a more inclusive participation to Rubin LSST activities, we aim to create a catalogue of publicly available interactive 3D graphics and 3D printed kits based on the modeling and interpretation of a number of physical processes causing photometric variability in YSOs that we plan to investigate with future Rubin LSST data. This action is in line with the Justice, Equity, Diversity & Inclusion (JEDI) group of the TVS SC, and will help to disseminate some of our results, and to adequately present Rubin/TVS science to visually impaired researchers and members of the community at large. Here we present the project and the first models of our catalogue.
title: Weinsberger Skalen zur Bewegungsbeobachtung (WSBB-1) – Standardisierte Bewegungsbeobachtung im forensischen Kontext
Creators: name: Adiarte, Sandra
name: Carbon, Claus-Christian
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: movement observation
subject: assessment
subject: movement therapy
subject: forensics
subject: 610 Medical sciences; Medicine

description: Ein Evaluationinstrument zu entwickeln, welches das Bewegungsverhalten von Patienten in therapeutischen Maßnahmen im klinischen Kontext dokumentiert, gestaltet sich bis dato als große Herausforderung. Aufwand und Nützlichkeit standardisierter Messmethodik halten den Anforderungen der [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Forschungstagung der Wissenschaftlichen Fachgesellschaft für Künstlerische Therapien (WFKT) 2019
title: Einzelfallstudie bei Bandscheibenprolaps und Tubertendinose
Creators: name: Berg, Sabine
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: In dieser Arbeit wird eine Einzelfallstudie über eine Patientin mit Bandscheibenprolaps und Sitzbeintendinose durchgeführt. Hierbei wird der Unterschied im therapeutischen Ansatz und der Wirkung auf die Patientin zwischen einer Eurythmietherapie-Behandlung und einer Physiotherapie-Behandlung[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Forschungstagung der Wissenschaftlichen Fachgesellschaft für Künstlerische Therapien (WFKT) 2019
Nilpotence and descent in equivariant stable homotopy theory
Creators: name: Mathew, Akhil
name: Naumann, Niko
name: Noel, Justin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Topology (math.AT)
subject: Category Theory (math.CT)
subject: FOS: Mathematics

description: Let $G$ be a finite group and let $\mathscr{F}$ be a family of subgroups of $G$. We introduce a class of $G$-equivariant spectra that we call $\mathscr{F}$-nilpotent. This definition fits into the general theory of torsion, complete, and nilpotent objects in a symmetric monoidal stable $\infty$-category, with which we begin. We then develop some of the basic properties of $\mathscr{F}$-nilpotent $G$-spectra, which are explored further in the sequel to this paper. In the rest of the paper, we prove several general structure theorems for $\infty$-categories of module spectra over objects such as equivariant real and complex $K$-theory and Borel-equivariant $MU$. Using these structure theorems and a technique with the flag variety dating back to Quillen, we then show that large classes of equivariant cohomology theories for which a type of complex-orientability holds are nilpotent for the family of abelian subgroups. In particular, we prove that equivariant real and complex $K$-theory, as well as the Borel-equivariant versions of complex-oriented theories, have this property.
description: 63 pages. Revised version, to appear in Advances in Mathematics
title: Mountain Lion (Puma concolor) and Feral Horse (Equus ferus) Interactions: Examining the Influence of a Non-Native Ungulate on Predator Behavior in a Semi-Arid Environment
Creators: name: Iacono, Peter C.
Publisher: name: Utah State University
Year: 2023

description: A non-native is a species that evolved in one ecosystem and has established within another. Non-native species can thrive in new ecosystems as they can spread quickly, outcompete and replace native species, and disrupt food webs. Domestic horses were brought to North America by Europeans in 1493. They are now found in 11 states across the western United States. Feral horses can negatively impact vegetation, endangered species habitat, compete with native species, and be important prey for mountain lions under certain conditions. But do feral horses affect the food web? Feral horses are managed by large removals to reduce the population, and therefore this food source can quickly decrease. I addressed two questions in Southeast, NV where, a horse removal occurred in December 2020 (455 horses; 45% of the population): (1) following removals, do mountain lions increase predation on native species, such as mule deer or bighorn sheep? and (2) Do mountain lions select feral horses over native species? I hypothesized: (1) horses will decrease from the diet and native prey will increase, and (2) mountain lions will select for native prey over feral horses. I deployed 49 cameras to determine prey availability and investigated 1,360 potential kill sites from 29 GPS-collared mountain lions. Prey was found at 1,056 sites. To test if mountain lions preyed more native species post-removal, I compared their diet in the years pre- and post-removal. I found that the diet did not change between years, indicating that they consumed horses and native prey similarly. To test if mountain lions were selecting for native prey, I compared each mountain lion's diet to their prey availability. The results showed mountain lions selected for horses during the growing season, while another two selected for deer during winter. Overall, feral horses made-up about 36% of the diet, with some individuals consuming horses more than others. In total, 342 horses were consumed by mountain lions during this study. I concluded that feral horse presence influences mountain lion predation behaviors, which is important for mountain lion and feral horse management in arid ecosystems that have many prey species
Increased sensitivity to kainic acid in a genetic model of reduced NMDA receptor function
Creators: name: Inada, Ken
name: Koller, Beverly H.
name: Duncan, Gary E.
name: Moy, Sheryl S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The pathophysiology of schizophrenia may involve reduced NMDA receptor function and experimental models of NMDA receptor hypofunction have proven useful for characterizing neurobiological abnormalities potentially relevant to schizophrenia. The present study assessed behavioral responses and induction of Fos after administration of kainic acid to wild type mice (NR1+/+) and mice with genetically reduced NMDA receptor expression (NR1neo/neo). At a dose of 20 mg/kg kainic acid induced lethal seizures in 100% of the NR1neo/neo mice tested but produced no lethal seizures in the wild type mice. The NR1neo/neo mice also exhibited enhanced behavioral responses to kainic acid at a dose of 15 mg/kg but no lethal seizures were produced by this dose. A greater induction of Fos was observed in neocortical and limbic cortical regions of the NR1neo/neo compared to NR1+/+ mice after administration of 15 mg/kg kainic acid. In contrast, there were no differences between the genotypes in kainic acid induced of Fos in the amygdala, hippocampus, lateral septum, and nucleus accumbens. In order to determine if altered behavioral phenotypes of the NR1neo/neo mice could be related to increased sensitivity of kainate receptors to endogenous glutamate, effects of the highly selective kainate antagonist LY382884 were examined. The kainate antagonist reduced the exaggerated acoustic startle responses, deficits in prepulse inhibition of acoustic startle, and motor hyperactivity in the NR1neo/neo mice. These findings suggest that selective kainate receptor antagonists could be novel therapeutic candidates for schizophrenia.
Barjols, place de la Rouguière, un homme alimente le foyer
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2024

Abstract
Effects of the selective kainate receptor antagonist ACET on altered sensorimotor gating in a genetic model of reduced NMDA receptor function
Creators: name: Moy, Sheryl S.
name: Duncan, Gary E.
name: Koller, Beverly H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The pathophysiology of schizophrenia may involve reduced NMDA receptor function. Accordingly, experimental models of NMDA receptor hypofunction may be useful for testing potential new antipsychotic agents and for characterizing neurobiological abnormalities relevant to schizophrenia. We demonstrated previously that mice under-expressing the NR1 subunit of the NMDA receptor show supersensitive behavioral responses to kainic acid and that a kainate receptor antagonist normalized altered behaviors in the mutant mice (NR1neo/neo). The present work examined effects of another selective kainate receptor antagonist, (S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxy-5-phenylthiophene-3-yl-methylpyrimidine-2,4-dione (ACET), on altered behavioral phenotypes in the genetic model of NMDA receptor hypofunction. ACET, at a dose of 15 mg/kg, partially reversed the deficits in prepulse inhibition produced by the mutation. The 15 mg/kg dose of ACET was also effective in reversing behavioral effects of the selective kainate agonist ATPA. However, ACET did not significantly reduce the increased locomotor activity and rearing behavior observed in the NR1neo/neo mice. These findings show that a highly selective kainate receptor antagonist can affect the deficits in sensorimotor gating in the NR1neo/neo mice. The results also provide further support for the idea that selective kainate receptor antagonists could be novel therapeutic candidates for schizophrenia.
title: Overcoming Barriers to Aquatic Plant Restoration: Addressing Gaps in Species Identification and Planting Techniques in the Intermountain West
Creators: name: Sinnott, Kate A.
Publisher: name: Utah State University
Year: 2023

description: Aquatic ecosystems provide many critical and economically valuable benefits, including drinking water, food, recreational opportunities, and water supply for irrigation and agriculture. However, the health of these systems has been severely impacted by human activities such as pollution, land conversion, and introductions of harmful species. Restoring native aquatic plants can help reverse this damage and reestablish benefits, though it is not a common practice. With an objective to increase capacity for aquatic plant restoration in the Intermountain West, I identified and addressed two major barriers: 1) a lack of confidence in aquatic species identification among wetland professionals, and 2) underdeveloped planting techniques that can be used over large scales and result in successful plant establishment. To address the first barrier, I produced the "Floating and Submerged Plants of Utah: Pocket Field Guide." The guide contains identification information, images, and interesting facts about 36 aquatic species, as well as a key to the Pondweed family. To address the second barrier, I conducted two field experiments to identify successful and scalable planting techniques in a river delta in the Intermountain West. In these experiments, I examined the performance of different planting methods (how plants are introduced to a site) and planting designs (how plants are arranged within a site; clumped and dispersed designs) for two types of plant materials (stem fragments and plugs—adult plants in soil). I found that planting methods had a significant effect on plant establishment across the plant material types for one of the native species tested, Ruppia cirrhosa, but not the other two species, Potamogeton nodosus and Stuckenia pectinata. I did not find significant effects of planting design. Based on these findings, I suggest that wetland professionals carefully pair different species with planting methods to balance scalability and plant establishment. I also suggest that logistical considerations (such as site accessibility), rather than potential ecological differences (such as species-specific traits that may affect plant establishment), can guide planting design choices. Addressing these barriers will increase the capacity for aquatic plant restoration in the Intermountain West and subsequently support the health of aquatic ecosystems.
Orexin-1 receptor antagonism does not reduce the rewarding potency of cocaine in Swiss–Webster mice
Creators: name: Jarrett, Thomas M.
name: Malanga, C. J.
name: McGuigan, Megan M.
name: Riday, Thorfinn T.
name: Fish, Eric W.
name: Robinson, J. Elliott
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The orexin family of hypothalamic neuropeptides has been implicated in reinforcement mechanisms relevant to both food and drug reward. Previous behavioral studies with antagonists at the orexin A-selective receptor, OX1, have demonstrated its involvement in behavioral sensitization, conditioned place-preference, and self-administration of drugs of abuse. Adult male Swiss-Webster mice were implanted with stimulating electrodes to the lateral hypothalamus and trained to perform intracranial self-stimulation (ICSS). The effects of the OX1-selective antagonist SB 334867 on brain stimulation-reward (BSR) and cocaine potentiation of BSR were measured. SB 334867 (10 – 30 mg/kg, i.p.) alone had no effect on ICSS performance or BSR threshold. Cocaine (1.0 – 30 mg/kg i.p.) dose-dependently potentiated BSR, measured as lowering of BSR threshold. This effect was not blocked by 30 mg/kg SB 334867 at any cocaine dose tested. In agreement with previous reports, SB 334867 resulted in a reduction of body weight 24 hours after acute administration. Based on these data, it is concluded that orexins acting at OX1 do not contribute to BSR; and are not involved in the reward-potentiating actions of cocaine on BSR. The data are discussed in the context of prior findings of SB 334867 effects on drug-seeking and drug-consuming behaviors.
title: Imagination und „Imaginatives Malen“ in der Kunsttherapie
Creators: name: Degen, Susanne
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: Kunsttherapie
subject: Imaginatives Malen
subject: Imagination
subject: Wohlbefinden
subject: Stimmung
subject: Affektivität
subject: Multiple Sklerose
subject: MBSR
subject: Coaching
subject: 610 Medical sciences; Medicine

description: Diese Einzelfallstudie untersucht, ob kreative Arbeit auch innerhalb der Vorstellung möglich ist und ob Vorstellungsbilder eine positive Auswirkung auf das Wohlbefinden, die Stimmung sowie die Affektivität haben – basierend auf der Intention, Menschen, die durch Erkrankungen in ihrer[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Forschungstagung der Wissenschaftlichen Fachgesellschaft für Künstlerische Therapien (WFKT) 2019
Barjols, place de la Rouguière, spectateurs et spectatrices de tous âges
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2024

Abstract
L'OEUVRE DES TRAVAILLEURS EUX-M�MES. IL SINDACALISMO D'AZIONE DIRETTA ITALIANO TRA ESILIO, CLANDESTINIT� E DIASPORA DEI MILITANTI
Creators: name: MASULLI, MARCO
Publisher: name: Universit� degli studi di Genova
Year: 2019

description: Starting from an historical reflection about internationalism and transnationalism, the research focuses on the reconstruction and analysis of the Italian syndicalism of direct action between 1910 and 1930, by facing the phases experienced between the illegality and the exile following the rise to power of the Italian Fascism. Intended as ? Collective Biography? of the movement, the thesis analyses political and existential itineraries made by some militants in France and in Spain, by connecting them to the political changes within the movement. Thanks to the study of the structure and transnational militants?action, as well as the totality of trade union practices and anti-capitalist and anti-fascist solidarity, the thesis wants to reconstruct the conditions that allow the movement spread on an international level although in the absence of stable coordination structures
Pharmacosynthetics: Reimagining the pharmacogenetic approach
Creators: name: Farrell, Martilias S.
name: Roth, Bryan L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Pharmacology, in its broadest interpretation, is defined as the study of the interaction between physiological entities and drugs. In modern neuropsychopharmacology, this interaction is viewed as the drug itself on one side and signal transducer (receptor), the signal transduction cascade (effector proteins, second messengers), the cellular response (transcriptional regulation, activity modulation), the organ response (brain circuitry modulation), and, finally, the whole organism response (behavior) on the other. In other words, pharmacology has structured itself around the idea that the exogenous molecule (the drug) encodes a “signal” leading to everything on the other side including, in extreme renditions, a physiological response. The inference is that engaging a particular signal transduction pathway in a defined cell type leads inexorably to a prototypic physiological response. Thus, for instance, serotonergic activation of 5-HT2A receptors in rat aortic smooth muscle cells leads to an increase in intracellular Ca++ (via IP3 release) and smooth muscle contraction (Roth et al., 1986). Here, we suggest that the invention of synthetic ligand – GPCR pairs (aka DREADDs, RASSLS, ‘pharmacogenetics’) permits the study of pharmacology using a shifted equation: more of the signal transduction elements moved to the left and, subsequently, under experimental control. For the purposes of disambiguation and to clarify this new interpretation as a creation of pharmacological manipulation, we present the term pharmacosynthetics to describe what has heretofore been called pharmacogenetics or chemicogenetics. This review discusses this new interpretation and reviews recent applications of the technology and considerations of the approach.
Proalgebraic crossed modules of quasirational presentations
Creators: name: Mikhovich, Andrey
Publisher: name: arXiv
Year: 2015
Subjects: subject: Group Theory (math.GR)
subject: Algebraic Geometry (math.AG)
subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics

description: We introduce the concept of quasirational relation modules for discrete and pro-$p$ presentations of discrete and pro-$p$ groups and show that aspherical presentations and their subpresentations are quasirational. In the pro-$p$-case quasirationality of pro-$p$-groups with a single defining relation holds. For every quasirational (pro-$p$)relation module we construct the so called $p$-adic rationalization, which is a pro-fd-module $\overline{R}\widehat{\otimes}\mathbb{Q}_p= \varprojlim R/[R,R\mathcal{M}_n]\otimes\mathbb{Q}_p$. We provide the isomorphisms $\overline{R^{\wedge}_w}(\mathbb{Q}_p)=\overline{R}\widehat{\otimes}\mathbb{Q}_p$ and $\overline{R_u}(\mathbb{Q}_p)=\mathcal{O}(G_u)^*$, where $R^{\wedge}_w$ and $R^{\wedge}_u$ stands for continuous prounipotent completions and corresponding prounipotent presentations correspondingly. We show how $\overline{R^{\wedge}_{w}}$ embeds into a sequence of abelian prounipotent groups. This sequence arises naturally from a certain prounipotent crossed module, the latter bring concrete examples of proalgebraic homotopy types. The old-standing open problem of Serre, slightly corrected by Gildenhuys, in its modern form states that pro-$p$-groups with a single defining relation are aspherical. Our results give a positive feedback to the question of Serre.
description: This is a corrected version of the paper which appeared in the Extended Abstracts Spring 2015, Interactions between Representation Theory, Algebraic Topology and Commutative Algebra, Research Perspectives CRM Barcelona, Vol.5, 2016
title: Quantifying the Impacts and Assessing the Permeability of a Divided Four-Lane Highway on Migratory Mule Deer
Creators: name: Taylor, Daniel P.
Publisher: name: Utah State University
Year: 2023

description: Increased human development and expansion has led to an ever-growing transportation network, which has both direct and indirect ecological impacts to local wildlife populations. In response, wildlife crossing structures have become an increasingly fundamental component of wildlife conservation throughout the United States. The focus of this study was a 13.5 km section of US Highway 395, Mono County, California. The California Department of Transportation recently identified this section of highway, hereafter known as the Mammoth Wildlife Crossing, as the highest priority location for wildlife crossing structures along US 395 within Mono County. The goal of this study was to use a multiple data source approach to identify successful and unsuccessful mule deer crossing locations within the project area and provide recommendations to Caltrans for crossing structure locations. To meet this goal, specific objectives included: (1) Conduct standardized roadside carcass counts that record the locations of mule deer involved in deer-vehicle-collision; (2) Create a heatmap of recorded locations that identifies segments of US 395 where collisions occur with the highest frequency; (3) Use GPS telemetry data from collared mule deer to model successful highway crossings in relation to surrounding environmental factors; (4) Evaluate the correspondents between outputs from the hot spot analysis results from our predictive model to examine the spatial relationship between successful and unsuccessful crossings. Results from our analysis identified three potential locations for wildlife crossings, that could be invaluable additions to US 395 to reduce wildlife mortality, restore and maintain necessary habitat connectivity for migratory mule deer, and most importantly, create a safer roadway for motorists.
title: Public Perceptions and Attitudes Toward Domestic Climate Migrants and Migration in the U.S.
Creators: name: Harris, Brittany Shae
Publisher: name: Utah State University
Year: 2023

description: Increasing frequency and intensity of extreme weather events due to global climate change have an important effect on human migration and relocation. Short-term extreme weather events like floods and wildfires are likely to continue to displace people. Long-term environmental changes like droughts and increasing temperatures may also contribute to increased human migration. This research aimed to better understand how people in the U.S. perceive domestic climate migrants, and what drives these perceptions. First, I investigated the relationship between public climate change risk perceptions and attitudes and perceptions about domestic climate migrants and migration. I found that people tend to rely on pre-existing climate change risk perceptions as they form attitudes toward domestic climate migrants and migration. Next, I examined the effects of spatial differences on perceptions and attitudes toward domestic climate migrants and migration. Across states, there was strong variation of these attitudes. I also found significant relationships between climate change risk perceptions and attitudes toward climate migrants at the state-level. Additionally, I identified states that converge and diverge from the relationship between climate change risk perceptions and attitudes toward climate migrants. Lastly, I evaluated the effects of climate migrant circumstances on perceived voluntariness (whether people think others are relocating voluntarily or involuntarily) and public support for relocation. The directness of climate change impacts and the extreme weather event incidence would occur were associated with perceived voluntariness of climate migrant relocation. Perceived voluntariness of relocation was a strong driver of public support for the development of climate migrant assistance programs in the U.S.
Changes in retinal and choroidal optical coherence tomography angiography indices among young adults and children over 1 year
Creators: name: Lal, Barsha
name: Alonso-Caneiro, David
name: Read, Scott A
name: Carkeet, Andrew
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Optical coherence tomography angiography (OCT-A) indices are likely to change across time and optometrists should be aware of the variability expected during childhood development and in healthy adults. Cross-sectional studies have shown that OCT-A indices are associated with age in adults and children. The aim of this study is to investigate longitudinal changes in retinal and choroidal OCT-A indices over 1 year among healthy children and young adults. This prospective longitudinal study captured macular OCT-A and OCT scans, and biometry measures at baseline and 1-year follow-up for 22 adults (18–30 years; −6.87 to +0.37 D) and 21 children (6–15 years; −5.75 to +0.25 D). Superficial and deep retinal layer, choriocapillaris and deep choroidal en face OCT-A images were analysed to extract magnification-corrected vascular indices in foveal, parafoveal and perifoveal regions. The retinal indices included foveal avascular zone metrics, perfusion, and vessel density. Flow deficit number, size, and density were extracted from choriocapillaris and perfusion density from deep choroid. Associations between annual changes in the OCT-A indices and axial length and baseline refraction were also studied. Among children, significant reductions were noted only in parafoveal superficial retinal and foveal and perifoveal deep retinal layer indices over 1 year (p < 0.05). Choroidal OCT-A indices in children and both retinal and choroidal OCT-A indices in adults did not show significant changes. Myopia was associated with a larger reduction in the perifoveal retinal OCT-A indices in children, and with increases in sub-foveal and sub-parafoveal choroidal indices in adults. There were associations between OCT-A indices and axial length changes but differently in adults and children. Significant changes were noted in retinal OCT-A indices over 1 year among children but not adults. In comparison, choroidal OCT-A indices in adults and children showed a stable morphology over this period of time.
title: Precise Determination of Charge Distributions in Electron Irradiated Polymers Via Pulsed Electroacoustic Measurements With Applications to Spacecraft Charging
Creators: name: Gibson, Zachary
Publisher: name: Utah State University
Year: 2023

description: Understanding how charge builds up and moves around in materials that are highly insulating, such as dielectrics, is important for many applications from power transmission to spacecraft charging. The leading cause of issues in spacecraft due to interactions with the space environment is spacecraft charging. That is, the accumulation of charge on insulating materials leads to arcing and sparking aboard the spacecraft. The most critical charging occurs due to electrons in a particular energy range of 10-50 keV. Electrons with these energies can travel 1’s to 10’s of microns into relevant materials. To measure where the charge is embedded and how it moves, the pulsed electroacoustic (PEA) method can be used. The PEA method allows for non-destructive measurements of embedded charge distributions in these dielectric materials. PEA instrumentation, test methods, and analysis were extensively characterized and improved. In this work, the PEA method was tested as to its relevance to spacecraft charging applications and the applicability was extended with a novel method for measuring shallowly deposited charge distributions in highly insulating materials. The PEA method is shown to be relevant and useful for understanding how charge builds up and moves inside dielectric materials in the context of spacecraft charging.
Combined treatment with acupuncture reduces effective dose and alleviates adverse effect of l-dopa by normalizing Parkinson's disease-induced neurochemical imbalance
Creators: name: Lee, Hyejung
name: Lee, Bena
name: Shim, Insop
name: Choo, Hyunwoo J.
name: Doo, Ah Reum
name: Chae, Younbyoung
name: Park, Jongbae J.
name: Kim, Seung Nam
name: Park, Ji Yeun
name: Park, Hi Joon
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: This study first showed the behavioural benefits of novel combination therapy of l-dopa with acupuncture on Parkinson’s disease, and its underlying mechanisms within basal ganglia. The previous study reported that acupuncture may improve the motor function of a Parkinson’s disease (PD) mouse model by increasing the dopamine efflux and turnover ratio of dopamine. Hence, we hypothesised that combining l-dopa with acupuncture would have a behavioural benefit for those with PD. We performed unilateral injections of 6-OHDA into the striatum of C57Bl/6 mice to model hemi-Parkinsonian attributes. To test motor function and dyskinetic anomalies, we examined cylinder behaviour and abnormal involuntary movement (AIM), respectively. We found that (1) a 50% reduced dose of l-dopa (7.5 mg/kg) combined with acupuncture showed an improvement in motor function that was comparable to mice given the standard dose of l-dopa treatment (15 mg/kg) only, and that (2) the combination treatment (l-dopa +acupuncture) was significantly superior in reducing AIM scores when equivalent doses of l-dopa were used. The combination treatment also significantly reduces the abnormal increase of GABA contents in the substantia nigra compared to the standard l-dopa treatment. Furthermore, abnormal expression of FosB, the immediate early gene of l-dopa induced dyskinesia (LID), was mitigated in the striatum by the combination treatment. All of these results indicate that acupuncture enhances the benefits of l-dopa on motor function with reduced dose of l-dopa and alleviating LID by normalising neurochemical imbalance within the basal ganglia.
Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders
Creators: name: Sagar, A.
name: Liu, W.
name: Levin-Decanini, T.
name: Jacob, S.
name: Carter, C. S.
name: Francis, S. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Oxytocin (OT) and arginine vasopressin (AVP) are two small, related neuropeptide hormones found in many mammalian species, including humans. Dysregulation of these neuropeptides have been associated with changes in behavior, especially social interactions. We review how the OT and AVP systems have been investigated in Autism Spectrum Disorder (ASD), Prader–Willi Syndrome (PWS), Williams Syndrome (WS) and Fragile X syndrome (FXS). All of these neurodevelopmental disorders (NDD) are marked by social deficits. While PWS, WS and FXS have identified genetic mutations, ASD stems from multiple genes with complex interactions. Animal models of NDD are invaluable for studying the role and relatedness of OT and AVP in the developing brain. We present data from a FXS mouse model affecting the fragile X mental retardation 1 (Fmr1) gene, resulting in decreased OT and AVP staining cells in some brain regions. Reviewing the research about OT and AVP in these NDD suggests that altered OT pathways may be downstream from different etiological factors and perturbations in development. This has implications for ongoing studies of the therapeutic application of OT in NDD.
title: Fragebogen zum Erleben der Kunsttherapiegruppe in der Psychosomatik aus Patientensicht (FEKTP)
Creators: name: Ganter-Argast, Christiane
name: Mander, Johannes
name: Zipfel, Stefan
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Die Kunsttherapie ist eine klinisch anerkannte Therapiemethode, jedoch gibt es immer noch wenige Studien, die sich mit der Wirksamkeit, Wirkfaktoren oder Wirkweisen der Kunsttherapie auseinandersetzen. Insbesondere fehlt bis zum heutigen Zeitpunkt ein speziell für die Kunsttherapie zugeschnittenes[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Forschungstagung der Wissenschaftlichen Fachgesellschaft für Künstlerische Therapien (WFKT) 2019
title: Physics-Guided Deep Learning for Solar Wind Modeling at L1 Point
Creators: name: Johnson, Robert M.
Publisher: name: Utah State University
Year: 2023

description: Neural networks are adept at finding patterns that are too long and too small for humans to find in data. Usually, this power is used to generate predictions with greater accuracy than most alternative models. However, we can also use this power to understand more about the data we train these networks on. We do this by changing the data that the networks train on and the data they are tested on. This allows us to both control the maximum length of a pattern and to compare data between different groups, in our case, different solar cycles. This thesis is our attempt to understand solar wind data better. We do this by proposing a physics based framework and comparing the results of different inputs and outputs through different networks. These results show three major things: 1, that training networks using the physical law of Ohm's law for an ideal plasma can improve network performance predictions; 2, that the specific characteristics of different solar cycles make them more suitable for training or testing; and 3, that while physics guided loss functions can be helpful in certain situations, they are no silver bullet to improved predictions.
title: Dissertationsprojekt: Evaluation musiktherapeutischer Methoden für die Kommunikationsanbahnung bei Kindern mit Mutismus
Creators: name: Künzel, Luisa
name: Sallat, Stephan
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Selektiver Mutismus ist eine Sprach- und Kommunikationsstörung, bei der Betroffene nicht mehr in der Lage sind, in allen Situationen oder mit allen Personen sprechen zu können. Selektiver Mutismus kann mit anderen Sprachstörungen einhergehen, ist häufig aber emotional bedingt [ref:5].[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Forschungstagung der Wissenschaftlichen Fachgesellschaft für Künstlerische Therapien (WFKT) 2019
Epidemiologia delle infezioni respiratorie acute nella popolazione assistita presso l?Ospedale Policlinico San Martino IRCCS di Genova nel periodo gennaio 2013 ? giugno 2019
Creators: name: GRAMMATICO, FEDERICO
Publisher: name: Universit� degli studi di Genova
Year: 2020

description: Acute Respiratory Infection (ARI) refers to a group of diseases characterized by symptoms of high or low respiratory tracts caused by different etiological agents. Such infections are one of the leading causes of morbidity and mortality worldwide. These are ubiquitous, highly contagious diseases that affect individuals of all ages, with greater severity in the child and elderly age groups. Samples for respiratory viruses research were received at the laboratory of Ospedale Policlinico San Martino, and analyzed between January 1, 2013 and June 31, 2019. Results from Multiplex Real Time PCR, were analysed. This method detects the main respiratory viruses (Adenovirus, Parainfluenza virus 1, Parainfluenza virus 2, Parainfluenza virus 3, Parainfluenza virus 4, Coronavirus 229E, Coronavirus NL63, Coronavirus OC43, RSV A, RSV B, Virus Influenza A, Influenza Virus B, Metapneumovirus, Rhinovirus, Enterovirus, Bocavirus). During study period, 16945 samples were received, of which 9158 were males. The data was stratified by gender, age, home department and virus detected. The departments most detected were those of hemato-oncology and medical area. The data will help to characterize the epidemiology of the viruses detected in the adult population, as a key element in the assessement of any preventive and therapeutic strategies
Prevalence of meibomian gland dysfunction at a tertiary centre in Taiwan
Creators: name: Chang, Yu-Min
name: Weng, Tzu-Heng
name: Chien, Chien-Cheng
name: Chen, Yi-Hao
name: Liang, Chang-Min
name: Tai, Ming-Cheng
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Space Science
Medicine
Cell Biology
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: Meibomian gland dysfunction and dry eye disease are closely related conditions that often coexist and can contribute to the development of each other. Understanding the similarities and differences between these diseases can assist clinicians in implementing effective treatments for both conditions in a clinical setting. Dry eye disease is a multifactorial disease of the tears and ocular surface. This study aimed to evaluate the demographic characteristics of patients with meibomian gland dysfunction in Taiwan, investigate the association between meibomian gland dysfunction and dry eye parameters, and estimate the prevalence of meibomian gland dysfunction among patients with dry eye symptoms at a tertiary referral centre. This cross-sectional study enrolled patients aged ≥20 years who complained of dry eye symptoms and visited a tertiary centre between September 2019 and March 2020. The patients completed the Ocular Surface Disease Index and Standard Patient Evaluation of Eye Dryness questionnaires before undergoing ocular examination. The lipid layer thickness and meiboscale scores were recorded. In addition, the study measured tear film break-up time, examined corneal staining, and evaluated the number of meibomian glands yielding liquid secretions using a slit lamp. The study evaluated 202 eyes of 202 patients with a mean age of 58.05 ± 13.34 years. The prevalence of meibomian gland dysfunction was 93%. Mean meiboscale score and age were negatively associated, and tear film break-up time was positively associated with the mean number of meibomian glands yielding liquid secretions. Hyperlipidaemia and smoking were the main risk factors for Meibomian gland dysfunction. The prevalence of meibomian gland dysfunction among patients with dry eye symptoms was extremely high at the tertiary centre, highlighting the strong relationship between Meibomian gland dysfunction and dry eye disease. Clinicians should consider meibomian gland dysfunction as a possible cause of dry eye.