cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Construire des espaces de voisinage. Institution, collectif de recherche et architectonique de la KBW
Creators: name: Despoix, Philippe
Publisher: name: La Rivista di Engramma
Year: 2023
Subjects: Aby Warburg
KBW
Warburg Library
Fritz Saxl
Gertrud Bing

description: This contribution, is an extract from Philippe Despoix, KBW – La Bibliothèque Warburg, laboratoire de pensée intermédiale (Presses du réel, Dijon 2023). The book reconstructs the original gestures that established the Warburg Library as a ‘laboratory’ for collective research into the ways in which images and knowledge have been transmitted since antiquity. Implemented by its founder Aby Warburg, with Fritz Saxl and Gertrud Bing, in the renowned setting that became the Kulturwissenschaftliche Bibliothek Warburg in the 1920s, these gestures are combined like so many technical mediations: photographing and collecting, cartographing and putting into series, constructing ‘neighbourhoods’, projecting, and finally exhibiting. Only these modes of arrangement and visualisation allowed for the specific concepts developed at the time, such as the “pathos formula” (Pathosformel), “posthumous life” (Nachleben) and “migration of images” (Bilderwanderung), “intermediate space” (Zwischenraum) and “space of thought” (Denkraum). It is the dynamic articulation of these operations, at the heart of which lies photographic reproduction, that distinguishes the Library and its image collection as an intermediary knowledge device. Its archaeology allows us to clarify the conditions of possibility of the space of thought opened up by the Warburgian instrument, the singularity of its visual anthropology, as well as its critical potential.
Role of Isoprenoid Lipids on the Heterotrimeric G Protein γ Subunit in Determining Effector Activation
Creators: name: Myung, Chang Seon
name: Liu, Wendy W.
name: Harden, T. Kendall
name: Garrison, James C.
name: Yasuda, Hiroshi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: Post-translational prenylation of heterotrimeric G protein gamma subunits is essential for high affinity alpha-beta gamma and alpha-beta gamma-receptor interactions, suggesting that the prenyl group is an important domain in the beta gamma dimer. To determine the role of the prenyl modification in the interaction of beta gamma dimers with effectors, the CAAX (where A indicates alipathic amino acid) motifs in the gamma1, gamma2, and gamma11 subunits were altered to direct modification with different prenyl groups. Six recombinant beta gamma dimers were overexpressed in baculovirus-infected Sf9 insect cells, purified, and examined for their ability to stimulate three phospholipase C-beta isozymes and type II adenylyl cyclase. The native beta1 gamma2 dimer (gamma subunit modified with geranylgeranyl) is more potent and effective in activating phospholipase C-beta than either the beta1 gamma1 (farnesyl) or the beta1 gamma11 (farnesyl) dimers. However, farnesyl modification of the gamma subunit in the beta1 gamma2 dimer (beta1 gamma2-L71S) caused a decrement in its ability to activate phospholipase C-beta. In contrast, both the beta1 gamma1-S74L (geranylgeranyl) and the beta1 gamma11-S73L (geranylgeranyl) dimers were more active than the native forms. The beta1 gamma2 dimer activates type II adenylyl cyclase about 12-fold; however, neither the beta1 gamma1 nor the beta1 gamma11 dimers activate the enzyme. As was the case with phospholipase C-beta, the beta1gamma2-L71S dimer was less able to activate adenylyl cyclase than the native beta1 gamma2 dimer. Interestingly, neither the beta1 gamma1-S74L nor the beta1 gamma11-S73L dimers stimulated adenylyl cyclase. The results suggest that both the amino acid sequence of the gamma subunit and its prenyl group play a role in determining the activity of the beta gamma-effector complex.
Additional details about numerical experiments from A topographic mechanism for arcing of dryland vegetation bands.
Creators: name: Gandhi, Punit
name: Werner, Lucien
name: Iams, Sarah
name: Gowda, Karna
name: Silber, Mary
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Environmental Science
subject: 60114 Systems Biology
subject: FOS: Biological sciences
subject: 60199 Biochemistry and Cell Biology not elsewhere classified
subject: 69999 Biological Sciences not elsewhere classified
subject: 10202 Biological Mathematics
subject: FOS: Mathematics

description: A description of additional numerical results for the topographically extended Klausmeier model and a simplified version of the Gilad model.
Supplementary methods and figures from Diversification dynamics of mammalian clades during the K–Pg mass extinction
Creators: name: Pires, Mathias M.
name: Rankin, Brian D.
name: Silvestro, Daniele
name: Quental, Tiago B.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences

description: Supplementary methods and figures
Ruthenium Red Modifies the Cardiac and Skeletal Muscle Ca 2+ Release Channels (Ryanodine Receptors) by Multiple Mechanisms
Creators: name: Tripathy, Ashutosh
name: Meissner, Gerhard
name: Xu, Le
name: Pasek, Daniel A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: The effects of ruthenium red (RR) on the skeletal and cardiac muscle ryanodine receptors (RyRs) were studied in vesicle-Ca(2+) flux, [(3)H]ryanodine binding, and single channel measurements. In vesicle-Ca(2+) flux measurements, RR was more effective in inhibiting RyRs at 0.2 microM than 20 microM free Ca(2+). [(3)H]Ryanodine binding measurements suggested noncompetitive interactions between RR inhibition and Ca(2+) regulatory sites of RyRs. In symmetric 0.25 M KCl with 10-20 microM cytosolic Ca(2+), cytosolic RR decreased single channel activities at positive and negative holding potentials. In close to fully activated skeletal (20 microM Ca(2+) + 2 mM ATP) and cardiac (200 microM Ca(2+)) RyRs, cytosolic RR induced a predominant subconductance at a positive but not negative holding potential. Lumenal RR induced a major subconductance in cardiac RyR at negative but not positive holding potentials and several subconductances in skeletal RyR. The RR-related subconductances of cardiac RyR showed a nonlinear voltage dependence, and more than one RR molecule appeared to be involved in their formation. Cytosolic and lumenal RR also induced subconductances in Ca(2+)-conducting skeletal and cardiac RyRs recorded at 0 mV holding potential. These results suggest that RR inhibits RyRs and induces subconductances by binding to cytosolic and lumenal sites of skeletal and cardiac RyRs.
Cosmological Signatures of Anisotropic Spatial Curvature
Creators: name: Pereira, Thiago S.
name: Marugán, Guillermo A. Mena
name: Carneiro, Saulo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: If one is willing to give up the cherished hypothesis of spatial isotropy, many interesting cosmological models can be developed beyond the simple anisotropically expanding scenarios. One interesting possibility is presented by shear-free models in which the anisotropy emerges at the level of the curvature of the homogeneous spatial sections, whereas the expansion is dictated by a single scale factor. We show that such models represent viable alternatives to describe the large-scale structure of the inflationary universe, leading to a kinematically equivalent Sachs-Wolfe effect. Through the definition of a complete set of spatial eigenfunctions we compute the two-point correlation function of scalar perturbations in these models. In addition, we show how such scenarios would modify the spectrum of the CMB assuming that the observations take place in a small patch of a universe with anisotropic curvature.
description: 21 pages, 1 figure. To appear in JCAP
Secretory Group IIA Phospholipase A 2 Generates Anti-apoptotic Survival Signals in Kidney Fibroblasts
Creators: name: Zhang, Yingpei
name: Lemasters, John
name: Herman, Brian
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: Mammalian group IIA phospholipase A(2) (PLA(2)) is believed to play important roles in inflammation, cell injury, and tumor resistance. However, the cellular site of action has not been clearly defined as it has long been recognized that group IIA PLA(2) is both a secretory and mitochondrial protein. The purpose of this study was to determine the subcellular target of the group IIA PLA(2) and its role in apoptosis stimulated by growth factor withdrawal. Cloning of the rat liver group IIA PLA(2) demonstrated a typical secretory signal and no alternative splicing of the primary transcript. When a sequence including the signal peptide and first 8 residues in the mature enzyme or the entire PLA(2) (including the signal peptide) was fused to enhanced green fluorescent protein, the fusion protein was directed to the secretory pathway rather than mitochondria in baby hamster kidney (BHK) cells. To examine the role of group IIA PLA(2) in cell injury, wild type (wt) rat group IIA PLA(2) and a mutant group IIA PLA(2) containing a His-47 --> Gln mutation (at the catalytic center) were transfected into BHK cells and cells stably expressing these constructs were isolated. After deprivation of growth factors, both normal BHK cells and BHK cells expressing mutant PLA(2) underwent massive apoptosis, while BHK cells expressing wt PLA(2) showed considerable resistance to growth factor withdrawal-induced apoptosis. The secretory PLA(2) inhibitors 12-epi-scalaradial and aristolochic acid abrogated resistance to apoptosis in the wt PLA(2) expressing cells. These two inhibitors did not induce cell death in the presence of fetal bovine serum, suggesting that they induce cell death by blocking PLA(2) generated survival signals. This study demonstrates that group IIA PLA(2) generates anti-apoptotic survival signals in BHK cells targeting the secretory pathway, and suggests that high levels of group IIA PLA(2) accumulated at inflammatory sites may not only regulate inflammation, but also may protect cells from unnecessary death induced by pro-inflammatory agents.
Mind, Memory and Museum. Warburg Renaissance Project. An interview with Bill Sherman
Creators: name: Bill Sherman, Ada Naval
Publisher: name: La Rivista di Engramma
Year: 2023
Subjects: Warburg Library
Warburg Institute
Renaissance Project

description: On the occasion of the development of the Warburg Renaissance project, in this contribution Bill Sherman, the Warburg Institute Director in charge responds to the reflections of Ada Naval and Giulia Zanon on the Institute’s past, present and future with special attention towards the Warburg Library.
Sphingolipid Activator Proteins Are Required for Epidermal Permeability Barrier Formation
Creators: name: Suzuki, Kunihiko
name: Sandhoff, Konrad
name: Doering, Thomas
name: Vielhaber, Gabriele
name: Holleran, Walter M.
name: Potratzt, Astrid
name: Elias, Peter M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: The epidermal permeability barrier is maintained by extracellular lipid membranes within the interstices of the stratum corneum. Ceramides, the major components of these multilayered membranes, derive in large part from hydrolysis of glucosylceramides mediated by stratum corneum beta-glucocerebrosidase (beta-GlcCerase). Prosaposin (pSAP) is a large precursor protein that is proteolytically cleaved to form four distinct sphingolipid activator proteins, which stimulate enzymatic hydrolysis of sphingolipids, including glucosylceramide. Recently, pSAP has been eliminated in a mouse model using targeted deletion and homologous recombination. In addition to the extracutaneous findings noted previously, our present data indicate that pSAP deficiency in the epidermis has significant consequences including: 1) an accumulation of epidermal glucosylceramides together with below normal levels of ceramides; 2) alterations in lipids that are bound by ester linkages to proteins of the cornified cell envelope; 3) a thickened stratum lucidum with evidence of scaling; and 4) a striking abnormality in lamellar membrane maturation within the interstices of the stratum corneum. Together, these results demonstrate that the production of pSAP, and presumably mature sphingolipid activator protein generation, is required for normal epidermal barrier formation and function. Moreover, detection of significant amounts of covalently bound omega-OH-GlcCer in pSAP-deficient epidermis suggests that deglucosylation to omega-OH-Cer is not a requisite step prior to covalent attachment of lipid to cornified envelope proteins.
D-brane on Deformed AdS_3 times S^3
Creators: name: Khouchen, Malak
name: Klusoň, Josef
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study D1-brane in AdS_3 times S^3 kappa-deformed background with non-trivial dilaton and Ramond-Ramond fields. We consider purely time-dependent and spatially-dependent ansatz where we study the solutions of the equations of motion for D1-brane in given background. We find that the behavior of these solutions crucially depends on the value of the parameter a that was introduced in [arXiv:1411.1066 [hep-th]].
description: Added References Minor changes were done where "D1 brane reaches the boundary" term was replaced by $D1 brane reaches \rho\rightarrow\infty$ We would like to express our special thanks to anonymous referee
The chemical composition of the aerial parts essential oil of Jacobaea delphiniifolia (Asteraceae) growing in Sicily (Italy)
Creators: name: Badalamenti, Natale
name: Merra, Rosalia
name: Schicchi, Rosario
name: Geraci, Anna
name: Sgadari, Francesco
name: Bruno, Maurizio
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified

description: Jacobaea is a small genus of plants belonging to Asteraceae family, formerly joint to Senecio genus, that includes more than 60 species and sub-species. Several taxa of this genus have been extensively studied both for their non-volatile and volatile metabolites. In the present study the chemical composition of the essential oil (EO) from aerial parts of Jacobaea delphiniifolia (Vahl) Pelser & Veldkamp, collected in Sicily, was analyzed by GC–MS. No one report has been previously published on the EO of this species. The result showed the presence of a large quantity of two metabolites, namely 1-undecene (63.57%) and thymol methyl ether (13.65%). Chemotaxonomic considerations were carried out by comparing the other oils of Jacobaea taxa studied so far.
(1912) Nathaniel Atkinson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Das Nachleben der Antike. Zur Einfühurung in die Bibliothek Warburg (1921)
Creators: name: Saxl, Fritz
Publisher: name: La Rivista di Engramma
Year: 2023
Subjects: Fritz Saxl
Aby Warburg
Warburg Library

description: Fritz Saxl’s first article on the Warburg Library, Das Nachleben der Antike. Zur Einführung in die Bibliothek Warburg, was written for the “Hamburger Universitäte Zeitunge”, W. Sem, 1920/21, n. 4 II Jahrgang, Heft 11. The article briefly summarises the salient aspects of the Warburg Library, highlighting a multidisciplinary approach to the study of Antiquity.
Probing neutrino magnetic moments at Spallation Neutron Source facilities
Creators: name: Kosmas, T. S.
name: Miranda, O. G.
name: Papoulias, D. K.
name: Tortola, M.
name: Valle, J. W. F.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Majorana neutrino electromagnetic properties are studied through neutral current coherent neutrino-nucleus scattering. We focus on the potential of the recently planned COHERENT experiment at the Spallation Neutron Source to probe muon-neutrino magnetic moments. The resulting sensitivities are determined on the basis of a chi^2 analysis employing realistic nuclear structure calculations in the context of the quasi-particle random phase approximation. We find that they can improve existing limits by half an order of magnitude. In addition, we show that these facilities allow for Standard Model precision tests in the low energy regime, with a competitive determination of the weak mixing angle. Finally, they also offer the capability to probe other electromagnetic neutrino properties, such as the neutrino charge-radius. We illustrate our results for various choices of experimental setup and target material.
description: 24 pages, 8 figures, to be published in PRD
Nebulose di pseudoscienza. Incertezza, pseudo-fatti e tensioni nella governance tecnoscientifica
Creators: name: Picardi, Ilenia
Publisher: name: Cambio. Rivista sulle Trasformazioni Sociali
Year: 2020

description: For some decades, science communication has been at the center of the academic reflection articulating the debate on the role of science in contemporary society and its renewing need for legitimacy. Today different strategies coexist in communication activities promoted by scientific institutions and researchers to communicate the results of their work. Such communication models seem to be overtaken by disintermediation processes and by new forms of mediation implemented by digital platforms. This paper reflects on the recent debate on pseudoscience. It analyses the phenomenon in connection to the more general transformation of technoscientific governance. Through complex mediation and negotiation activities, changes in scientific governance transform both scientific knowledge and practices and the processes through which policy is looking for technoscientific legitimation, while science itself is being continuously constrained to look for its own legitimacy in the public arena (through fund raising and trust seeking). The intersection between pseudoscience and tensions inside the governance of technoscience identifies three main issues: the role of scientific expertise in society, trust in technoscience, and the relationship between technoscience and democracy. These concerns define the main current challenges of technoscience communication.
description: Cambio. Rivista sulle Trasformazioni Sociali, Vol. 9 No. 18 (2019): Narrating Science: Risks and Opportunities in the Information Society
(1914) Gladys Zena [Mitchell]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional details about numerical experiments from A topographic mechanism for arcing of dryland vegetation bands
Creators: name: Gandhi, Punit
name: Werner, Lucien
name: Iams, Sarah
name: Gowda, Karna
name: Silber, Mary
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Environmental Science
subject: 60114 Systems Biology
subject: FOS: Biological sciences
subject: 60199 Biochemistry and Cell Biology not elsewhere classified
subject: 69999 Biological Sciences not elsewhere classified
subject: 10202 Biological Mathematics
subject: FOS: Mathematics

description: A description of additional numerical results for the topographically extended Klausmeier model and a simplified version of the Gilad model.
The Escherichia coli MutL Protein Physically Interacts with MutH and Stimulates the MutH-associated Endonuclease Activity
Creators: name: Hall, Mark C.
name: Matson, Steven W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: All possible pairwise combinations of UvrD, MutL, MutS, and MutH were tested using the yeast two-hybrid system to identify potential interactions involving mismatch repair proteins. A two-hybrid screen previously identified a physical interaction between MutL and UvrD. Although several other known interactions were not observed, a novel interaction between MutL and MutH was detected. A series of truncations from the NH2 and COOH termini of MutL demonstrated that the COOH-terminal 218 amino acids were sufficient for the two-hybrid interaction with MutH. Removal of a small number of residues from either the NH2 or COOH termini of MutH eliminated the two-hybrid interaction with MutL. Protein affinity chromatography experiments confirmed that MutL, but not MutS, physically associates with MutH. Furthermore, MutL greatly stimulated the d(GATC)-specific endonuclease activity of MutH in the absence of MutS and a mispaired base. Stimulation of the MutH-associated endonuclease activity by MutL was dependent on ATP binding but not ATP hydrolysis. Further stimulation of this reaction by MutS required the presence of a DNA mismatch and a hydrolyzable form of ATP. These results suggest that MutL activates the MutH-associated endonuclease activity through a physical interaction during methyl-directed mismatch repair in Escherichia coli.
title: The use of cationic surfactants in marine anti-fouling applications
Creators: name: Smith, Margaret J.
Publisher: name: University of Glasgow
Year: 1997
Subjects: subject: Ocean engineering.

description: The protection, from fouling, of marine sensors is at present one of the major problems facing those wishing to collect data from the world's oceans. Sensors, such as transmissometers, have their ability to monitor light levels reduced to practically zero within seven days during marine trials in Scottish coastal waters. In this study the use of cationic surface-active agents (surfactants), in particular quaternary ammonium compounds and biguanides, incorporated into hydrogels are investigated as possible anti-fouling protection for such sensors. In this research it has been shown that the dual chemical and physical properties of some quaternary ammonium compounds and biguanides prevent marine fouling, including microfouling, for up to 15 weeks. Due to the ability of these materials to form micelles their release is slowed down and they are able to remain bound to their polymeric substrate, hydrogel. The slow to zero release of these chemicals makes them attractive alternatives to the current toxic anti-fouling materials. The qualitative and quantitative analysis of the quaternary ammonium compounds and the biguanides are considered and successful, and robust, analytical methods are developed and used within this study. The principles behind the analytical methods are explained, as is the credibility of the chosen technique.
From holography towards real-world nuclear matter
Creators: name: Li, Si-wen
name: Schmitt, Andreas
name: Wang, Qun
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Quantum chromodynamics is notoriously difficult to solve at nonzero baryon density, and most models or effective theories of dense quark or nuclear matter are restricted to a particular density regime and/or a particular form of matter. Here we study dense (and mostly cold) matter within the holographic Sakai-Sugimoto model, aiming at a strong-coupling framework in the wide density range between nuclear saturation density and ultra-high quark matter densities. The model contains only three parameters, and we ask whether it fulfills two basic requirements of real-world cold and dense matter, a first-order onset of nuclear matter and a chiral phase transition at high density to quark matter. Such a model would be extremely useful for astrophysical applications because it would provide a single equation of state for all densities relevant in a compact star. Our calculations are based on two approximations for baryonic matter, firstly an instanton gas and secondly a homogeneous ansatz for the non-abelian gauge fields on the flavor branes of the model. While the instanton gas shows chiral restoration at high densities but an unrealistic second-order baryon onset, the homogeneous ansatz behaves exactly the other way around. Our study thus provides all ingredients that are necessary for a more realistic model and allows for systematic improvements of the applied approximations.
description: 31 pages, 7 figures, v2: references added, version to appear in Physical Review D
Towards 1 Gbps/UE in Cellular Systems: Understanding Ultra-Dense Small Cell Deployments
Creators: name: Lopez-Perez, David
name: Ding, Ming
name: Claussen, Holger
name: Jafari, Amir H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Todays heterogeneous networks comprised of mostly macrocells and indoor small cells will not be able to meet the upcoming traffic demands. Indeed, it is forecasted that at least a 100x network capacity increase will be required to meet the traffic demands in 2020. As a result, vendors and operators are now looking at using every tool at hand to improve network capacity. In this epic campaign, three paradigms are noteworthy, i.e., network densification, the use of higher frequency bands and spectral efficiency enhancement techniques. This paper aims at bringing further common understanding and analysing the potential gains and limitations of these three paradigms, together with the impact of idle mode capabilities at the small cells as well as the user equipment density and distribution in outdoor scenarios. Special attention is paid to network densification and its implications when transitioning to ultra-dense small cell deployments. Simulation results show that network densification with an average inter site distance of 35 m can increase the cell- edge UE throughput by up to 48x, while the use of the 10GHz band with a 500MHz bandwidth can increase the network capacity up to 5x. The use of beamforming with up to 4 antennas per small cell base station lacks behind with cell-edge throughput gains of up to 1.49x. Our study also shows how network densifications reduces multi-user diversity, and thus proportional fair alike schedulers start losing their advantages with respect to round robin ones. The energy efficiency of these ultra-dense small cell deployments is also analysed, indicating the need for energy harvesting approaches to make these deployments energy- efficient. Finally, the top ten challenges to be addressed to bring ultra-dense small cell deployments to reality are also discussed.
title: Role of the Duplex-Doppler Ultrasound in the Hepatosplenic schistosomiasis
Creators: name: Belfiore, Maria Paola
Publisher: name: European Congress of Radiology
Year: 2012
Subjects: subject: Obstruction / Occlusion
subject: Infection
subject: Haemodynamics / Flow dynamics
subject: Structured reporting
subject: Socio-economic issues
subject: Education
subject: Ultrasound
subject: MR
subject: CT
subject: Vascular
subject: Spleen

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal Information References
description: Learning objectives: The purpose of this study is to describe our experience concerning the Schistosomiasis disease studied with Duplex-Doppler-color ultrasound...
A new β-carboline-type alkaloid from the flowers of Calotropis gigantea (L.) W.T.Aiton
Creators: name: Dang, Phu H.
name: Tran, Tu H.
name: Le, Tho H.
name: V., Truong N.
name: Nguyen, Hai X.
name: Nguyen, Mai T. T.
name: Nguyen, Nhan T.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Cancer

description: In our antioxidant screening of some Vietnamese plant extracts, the CHCl3-soluble fraction from Calotropis gigantea (L.) W.T.Aiton flowers showed moderate DPPH free radical scavenging activity with an IC50 value of 55.8 μg/mL. Thus, a further phytochemical study was carried out to obtain five alkaloids, including a new β-carboline-type alkaloid, caloside H (1). These known compounds were identified as 5-hydroxy-(2-methoxymethyl)pyridine (2), nicotinic acid (3), p-(acetylamino)phenol (4), and thymine (5). These structures were determined based on the NMR spectroscopic analysis. In antioxidant assay, caloside H at concentration of 100 μM showed DPPH radical scavenging capacity with a percentage of inhibition of 40.2%. In addition, a plausible biosynthetic pathway for the formation of caloside H was proposed based on the Schiff base formation and Mannich-like reaction.
The Influence of Chromosomal Location on the Expression of Two Transgenes in Mice
Creators: name: Smithies, Oliver
name: Hatada, Seigo
name: Kuziel, William
name: Maeda, Nobuyo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: We have generated mice having a single copy of the human haptoglobin gene (Hp2), driven by its natural promoter, and a neomycin resistance gene (Neo), driven by a herpes simplex thymidine kinase promoter with polyoma enhancers, inserted into two defined chromosomal locations, the Hprt locus on the X-chromosome and the apolipoprotein (apo) AI-CIII gene cluster on chromosome 9. The haptoglobin promoter is highly specialized in its tissue of action; the viral promoter has few restrictions. The apoAI-CIII gene is naturally active in only two tissues, whereas the Hprt gene region is ubiquitously active. Expression of both transgenes at substantial levels was achieved only (a) when the transgenes were inserted into the genome close to a known tissue-specific enhancer/locus control region in the apoAI-CIII gene cluster, and (b) when known conditions for function of their promoters were met. The specificities of the two chromosomal regions and of the two promoters are preserved, but their interactions are not specific. We conclude that transgenes are affected by locus-related enhancers in the same manner as nearby endogenous genes. Our experiments reinforce the usefulness of using gene targeting to direct single-copy transgenes to appropriate chromosomal locations.
How an improved implementation of H2 self-shielding influences the formation of massive stars and black holes
Creators: name: Hartwig, Tilman
name: Glover, Simon C. O.
name: Klessen, Ralf S.
name: Latif, Muhammad A.
name: Volonteri, Marta
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: High redshift quasars at z>6 have masses up to ~$10^9$ M$_\odot$. One of the pathways to their formation includes direct collapse of gas, forming a supermassive star, precursor of the black hole seed. The conditions for direct collapse are more easily achievable in metal-free haloes, where atomic hydrogen cooling operates and molecular hydrogen (H2) formation is inhibited by a strong external UV flux. Above a certain value of UV flux (J_crit), the gas in a halo collapses isothermally at ~$10^4$ K and provides the conditions for supermassive star formation. However, H2 can self-shield, reducing the effect of photodissociation. So far, most numerical studies used the local Jeans length to calculate the column densities for self-shielding. We implement an improved method for the determination of column densities in 3D simulations and analyse its effect on the value of J_crit. This new method captures the gas geometry and velocity field and enables us to properly determine the direction-dependent self-shielding factor of H2 against photodissociating radiation. We find a value of J_crit that is a factor of two smaller than with the Jeans approach (~2000 J_21 vs. ~4000 J_21). The main reason for this difference is the strong directional dependence of the H2 column density. With this lower value of J_crit, the number of haloes exposed to a flux >J_crit is larger by more than an order of magnitude compared to previous studies. This may translate into a similar enhancement in the predicted number density of black hole seeds.
description: 14 pages, 12 figures, published in MNRAS
(1915) Edgar Mitchell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
MUHANDIS O'QITUVCHILARDA KASBIY KOMPETENTLIKNI RIVOJLANTIRISH USULLARI
Creators: name: Rahmatova, Barnogul
Publisher: name: Zenodo
Year: 2023

description: Shiddat bilan rivojlanayotgan bozor munosabatlari sharoitida mehnat bozorida yetakchi o'rin egallagan kuchli raqobatga chidamli bo'lish har bir soha vakilidan kasbiy kompetentlikka ega bo'lish, uni uzluksiz ravishda rivojlantirib borishni taqozo qilmoqda.
The Propeptides of the Vitamin K-dependent Proteins Possess Different Affinities for the Vitamin K-dependent Carboxylase
Creators: name: Lin, Pen Jen
name: Stanley, Thomas B.
name: Jin, Da Yun
name: Stafford, Darrel W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: The vitamin K-dependent gamma-glutamyl carboxylase catalyzes the modification of specific glutamates in a number of proteins required for blood coagulation and associated with bone and calcium homeostasis. All known vitamin K-dependent proteins possess a conserved eighteen-amino acid propeptide sequence that is the primary binding site for the carboxylase. We compared the relative affinities of synthetic propeptides of nine human vitamin K-dependent proteins by determining the inhibition constants (Ki) toward a factor IX propeptide/gamma-carboxyglutamic acid domain substrate. The Ki values for six of the propeptides (factor X, matrix Gla protein, factor VII, factor IX, PRGP1, and protein S) were between 2-35 nM, with the factor X propeptide having the tightest affinity. In contrast, the inhibition constants for the propeptides of prothrombin and protein C are approximately 100-fold weaker than the factor X propeptide. The propeptide of bone Gla protein demonstrates severely impaired carboxylase binding with an inhibition constant of at least 200,000-fold weaker than the factor X propeptide. This study demonstrates that the affinities of the propeptides of the vitamin K-dependent proteins vary over a considerable range; this may have important physiological consequences in the levels of vitamin K-dependent proteins and the biochemical mechanism by which these substrates are modified by the carboxylase.
Supplementary Tables S1-S6 from Ancient plants with ancient fungi: liverworts associate with early-diverging arbuscular mycorrhizal fungi.
Creators: name: Rimington, William R.
name: Pressel, Silvia
name: Duckett, Jeffrey G.
name: Field, Katie J.
name: Read, David J.
name: Bidartondo, Martin I.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Molecular Biology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Plant Biology

description: Full collection details, summary tables, comparisons to earlier studies and microscopy measurements
The Role of Focal Adhesion Kinase Binding in the Regulation of Tyrosine Phosphorylation of Paxillin
Creators: name: Broome, Jill M.
name: Thomas, Jeffrey W.
name: Schaller, Michael D.
name: Griffin, James D.
name: Lombardo, Christian R.
name: Salgia, Ravi
name: Cooley, Marion A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: Focal adhesion kinase (FAK) and paxillin are focal adhesion-associated, phosphotyrosine-containing proteins that physically interact. A previous study has demonstrated that paxillin contains two binding sites for FAK. We have further characterized these two binding sites and have demonstrated that the binding affinity of the carboxyl-terminal domain of FAK is the same for each of the two binding sites. The presence of both binding sites increases the affinity for FAK by 5-10-fold. A conserved paxillin sequence called the LD motif has been implicated in FAK binding. We show that mutations in the LD motifs in both FAK-binding sites are required to dramatically impair FAK binding in vitro. A paxillin mutant containing point mutations in both FAK-binding sites was characterized. The mutant exhibited reduced levels of phosphotyrosine relative to wild type paxillin in subconfluent cells growing in culture, following cell adhesion to fibronectin and in src-transformed fibroblasts. These results suggest that paxillin must bind FAK for maximal phosphorylation in response to cell adhesion and that FAK may function to direct tyrosine phosphorylation of paxillin in the process of transformation by the src oncogene.
Notes on the Warburg Library (1934)
Creators: name: Bing, Gertrud
Publisher: name: La Rivista di Engramma
Year: 2023
Subjects: The Warburg Institute
The Warburg Library
Gertrud Bing

description: In this text, written in the aftermath of the arrival of the Warburg Library in London, Assistant Director Gertrud Bing describes simply but fully the genesis, history, structure, mission, and meaning of the library conceived by Aby Warburg.
Habitats: Ecological and morphological considerations from Ancient plants with ancient fungi: liverworts associate with early-diverging arbuscular mycorrhizal fungi.
Creators: name: Rimington, William R.
name: Pressel, Silvia
name: Duckett, Jeffrey G.
name: Field, Katie J.
name: Read, David J.
name: Bidartondo, Martin I.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Molecular Biology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Plant Biology

description: Further detail on the impacts of habitat on fungal colonisation of liverworts
(1913) Elizabeth Pickard
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The Structural Basis for the Increased Immunogenicity of Two HIV-Reverse Transcriptase Peptide Variant/Class I Major Histocompatibility Complexes
Creators: name: Collins, Edward J.
name: Pogue-Caley, Rebecca R.
name: Kirksey, Timothy J.
name: Frelinger, Jeffrey A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: Designing altered peptide ligands to generate specific immunological reactivity when bound to class I major histocompatibility complexes is important for both therapeutic and prophylactic reasons. We have previously shown that two altered peptides, derived from human immunodeficiency virus (HIV)-reverse transcriptase (RT) residues 309-317, are more immunogenic in vitro than the wild-type peptide. One peptide variant, I1Y, was able to stimulate RT-specific cytotoxic T cells from the blood of three HIV-infected individuals better than the wild-type RT peptide. Both I1Y and I1F peptide variants increase the cell surface half-life of the peptide-class I complex approximately 3-fold over that of the RT peptide but have different immunological activities. These peptides are candidates for the design of vaccines for HIV due to their increased immunogenicity. To understand the basis for the increased cell surface stability compared with wild-type peptide and to understand the differences in T cell recognition between I1Y and I1F, we determined the x-ray crystal structures of the two class I MHC-peptide complexes. These structures indicate that the increased cell surface half-life is due to pi-pi stacking interactions between Trp-167 of HLA-A2.1 and the aromatic P1 residues of I1F and I1Y. Comparison of the structures and modeling potential T cell receptor (TCR) interactions suggests that T cell interactions and immunogenicity are different between I1Y and I1F for two reasons. First, subtle changes in the steric and polar properties of the I1Y peptide affect TCR engagement. Second, water-mediated hydrogen bond interactions between the P1-Tyr and the P4-Glu peptide residues increase peptide side chain rigidity of residues critical for TCR engagement.
Supplemental data_Urban Climate Adaptation and Mitigation Action Plans: A Critical Review
Creators: name: Dacosta Aboagye, Prince
name: Sharifi, Ayyoob
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 370201
subject: Climate change processes
classificationCode: 330413
subject: Urban planning and health

description: The supplemental data is a list of appendices in the manuscript titled "Urban Climate Adaptation and Mitigation Action Plans: A Critical Review".
Decoherence and Quantum Error Correction for Quantum Computing and Communications
Creators: name: Martinez, Josu Etxezarreta
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum technologies have shown immeasurable potential to effectively solve several information processing tasks such as prime number factorization, unstructured database search or complex macromolecule simulation. As a result of such capability to solve certain problems that are not classically tractable, quantum machines have the potential revolutionize the modern world via applications such as drug design, process optimization, unbreakable communications or machine learning. However, quantum information is prone to suffer from errors caused by the so-called decoherence, which describes the loss in coherence of quantum states associated to their interactions with the surrounding environment. This decoherence phenomenon is present in every quantum information task, be it transmission, processing or even storage of quantum information. Consequently, the protection of quantum information via quantum error correction codes (QECC) is of paramount importance to construct fully operational quantum computers. Understanding environmental decoherence processes and the way they are modeled is fundamental in order to construct effective error correction methods capable of protecting quantum information. In this thesis, the nature of decoherence is studied and mathematically modelled; and QECCs are designed and optimized so that they exhibit better error correction capabilities.
description: PhD dissertation by Josu Etxezarreta Martinez defended on 15th february 2022
Thermodynamics of the frustrated $J_1$-$J_2$ Heisenberg ferromagnet on the body-centered cubic lattice with arbitrary spin
Creators: name: Müller, P.
name: Richter, J.
name: Hauser, A.
name: Ihle, D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We use the spin-rotation-invariant Green's function method as well as the high-temperature expansion to discuss the thermodynamic properties of the frustrated spin-$S$ $J_{1}$-$J_{2}$ Heisenberg magnet on the body-centered cubic lattice. We consider ferromagnetic nearest-neighbor bonds $J_1 < 0$ and antiferromagnetic next-nearest-neighbor bonds $J_2 \ge 0$ and arbitrary spin $S$. We find that the transition point $J_2^c$ between the ferromagnetic ground state and the antiferromagnetic one is nearly independent of the spin $S$, i.e., it is very close to the classical transition point $J_2^{c,{\rm clas}}= \frac{2}{3}|J_1|$. At finite temperatures we focus on the parameter regime $J_2
description: 19 pages, 10 figures, version as in EPJB
Supplementary Figures S1-10 from Ancient plants with ancient fungi: liverworts associate with early-diverging arbuscular mycorrhizal fungi.
Creators: name: Rimington, William R.
name: Pressel, Silvia
name: Duckett, Jeffrey G.
name: Field, Katie J.
name: Read, David J.
name: Bidartondo, Martin I.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Molecular Biology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Plant Biology

description: Global map of collection sites, species accumulation curves, ancestral reconstruction and additional phylogenetic trees and microscopy images
Glyco-conjugation in 3-β-anhydroicaritine
Creators: name: Zhao, Zhao
name: Cui, Hanqi
name: Wang, Xianheng
name: Zhang, Jianyong
name: Zhao, Changkuo
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Cancer

description: A convenient method has been developed for the glycol-conjugation in 3-position of β-anhydroicaritine in a reasonable yield. The structure of the 3-glycosylated β-anhydroicaritine derivatives was confirmed to be correct by 1H NMR, 13C NMR and HRMS spectrum. These compounds are less soluble than icaritin, but more soluble than icariside II in CCl4. The screening results showed that compounds 12h, 12i and 12j had higher cytotoxicity to HepG2 and MCF-7 at a concentration of 50 μM.
О ЗАДАЧАХ ОРГАНОВ ВНУТРЕННИХ ДЕЛ И УГОЛОВНО-ИСПОЛНИТЕЛЬНОЙ СИСТЕМЫ ПО ПРОТИВОДЕЙСТВИЮ ЭКСТРЕМИСТСКОЙ И ТЕРРОРИСТИЧЕСКОЙ ДЕЯТЕЛЬНОСТИ: СОВРЕМЕННОЕ СОСТОЯНИЕ, МЕТОДЫ И ПРИЕМЫ ПРОФИЛАКТИКИ
Creators: name: Николай Викторович Румянцев
Publisher: name: Вестник Московского университета МВД России
Year: 2020
Subjects: экстремизм
терроризм
противодействие
уголовно-исполнительная система
учреждения

description: Рассмотрены некоторые вопросы профилактики противоправной экстремистской и террористической деятельности подразделениями органов внутренних дел и уголовно-исполнительной системы, а также факторы, препятствующие осуществлению противодействия, изучаемым преступным явлениям.