cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
D2.2 Financial Use Case: Requirements, Scenario Definitions and Initial Evaluation Report
Creators: name: Project Consortium Members
Publisher: name: Zenodo
Year: 2020

description: Deliverable D2.2 reports on the results of the requirements’ collection for INFORE’s Financial use case and INFORE’s user scenarios for forecasting price swings, systemic risk prediction and decision support for investment opportunities. In particular, extracting actionable insights from the markets’ behavior, spotting profitable investments based on trading instruments’ volatility and seasonal price patterns, as well as the in-depth analysis of market risk are the use case scenarios from the INFORE Description of Work (DoW - see WP2), which are studied at a deeper level through the expert user interviews. Derived from the expert interviews, this deliverable details the role of players who interact with the financial applications. Furthermore, individual user scenarios, namely Forecasting price swings (FPS), Systemic risk prediction and early warning (SRP) and Decision support for investment opportunities (DSI) and their specific requirements and interactions with INFORE are summarized. On top of this, the deliverable provides preconditions for the data streams to be processed by INFORE and the algorithms to be applied to price swing prediction, risk calculation, and detection of investment opportunities. Based on the findings described in D2.1 first prototypes were implemented. These implementations are the base of the evaluation in this deliverable. They have been provided to expert users to allow them to investigate on features and function based on the findings from D2.1. In addition, enhancements towards final prototypes have been identified through questionnaires and interviews. This deliverable updates and refines the scenario definition and the use case requirements of Deliverable D2.1 and presents an initial evaluation of the INFORE prototype on this use case.
Paediatric hospital admissions for psychiatric and psychosocial reasons during the first year of the COVID-19 pandemic
Creators: name: McDonnell, T.
name: Conlon, C.
name: McNicholas, F.
name: Barrett, E.
name: Barrett, M.
name: Cummins, F.
name: Hensey, C.
name: McAuliffe, E.
name: Nicholson, E.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Increases in youth psychiatric presentations to out-patient and emergency department settings during COVID-19 have been reported. This study, using data from five hospitals in Ireland, examines changes in the number and type of paediatric admissions during COVID-19 (March 2020 – February 2021) compared to the previous two years. ICD-10 classification was used to establish admissions with mental, behavioural, neuro-developmental disorders and psychosocial reasons (MBN-PS). Overall hospital admissions fell by 25.3%, while MBN-PS fell by only 2.6%, mostly during an initial lockdown. Admissions for MBN-PS increased in July-August (9.2%), increased further in September-December (28.3%), returning to pre-COVID-19 levels in January–February 2021. Significant increases were observed among youths with anorexia nervosa (47.8%), other eating disorders (42.9%), and admissions for anxiety (29.6%), with these effects relating to females only. Although admissions for self-harm increased (3%) and rates of ASD admissions reduced (17%), these were not statistically significant. The disproportionate increase in admissions for MBN-PS compared to medical admissions suggests an adverse effect of COVID-19 on youth mental health, for females in particular, and supports previous reports of a pandemic specific increase in eating psychopathology. Combined community and acute service delivery and capacity planning are urgently needed given the prior underfunding of services pre-pandemic.
The Broadbent Theatre Rebranding Community Project: Discover the community project in the village of Wickenby, Lincolnshire
Creators: name: Gatfield, Rowan
Publisher: name: University of Lincoln
Year: 2024
Subjects: W210 - Graphic design
W473 - Community theatre

description: This Google Arts and Culture Exhibition of typography and illustrated works tells the story of a community project, which took an iterative, consultative (ActionResearch) approach, starting in 2020 where the idea to rebrand and reinvigorate the theatre was pitched to the governing committee just, prior to the onset of the Covid 19 Pandemic.Under threat of closure, but also identifying the opportunity to use the time under lockdown to reimagine and renovate the theatres’ brand and space, the proposal was approved. What followed can best be described as deductive reinterpretation of the theatre's rich history.Working alongside artist Janis bowley, as a member of the Broadbent Committee this project served to unite and ignite a community into action resulting in a year long process of hands of renovation, rebranding , repositioning and illustratve illumination of the story of the Concientious oBJECTOR fram Training Scheme and the lindsey Rural Players
D2.1 Financial Use Case: Initial Requirements and Scenario Definitions
Creators: name: Project Consortium Members
Publisher: name: Zenodo
Year: 2019

description: Deliverable D2.1 reports on the results of the requirements’ collection for INFORE’s Financial use case and INFORE’s user scenarios for forecasting price swings, systemic risk prediction and decision support for investment opportunities. In particular, extracting actionable insights from the markets’ behavior, spotting profitable investments based on trading instruments’ volatility and seasonal price patterns, as well as the in-depth analysis of market risk are the use case scenarios from the INFORE Description of Work (DoW - see WP2), which are studied at a deeper level through the expert user interviews. Derived from the expert interviews, this deliverable details the role of players who interact with the financial applications. Furthermore, individual user scenarios and their specific requirements and interactions with INFORE are summarized. On top of this, the deliverable provides preconditions for the data streams to be processed by INFORE and the algorithms to be applied to price swing prediction, risk calculation, and detection of investment opportunities.
268. Central nervous system involvement in ANCA-associated vasculitis – a retrospective cohort study
Creators: name: Masiak1, Anna
name: Ziętkiewicz1, Marcin
name: Dębska-Ślizień2, Alicja
name: Zdrojewski1, Zbigniew
Publisher: name: Zenodo
Year: 2022
Subjects: Vasculitis
ANCA
Abstracts
Giant Cell Arthritis
MPA
GPA
EGPA
Takayasu
IgA vasculitis

description: Background: Both peripheral and central nervous system (CNS) may be involved in patients with ANCA-associated vasculitis (AAV), with peripheral symptoms predominating. CNS involvement is rare symptom of AAV with reported prevalence rate of 7% to 11%. Methods: The purpose of this study was to describe the clinical presentation of patients with ANCA-associated vasculitis (GPA - granulomatosis with polyangiitis and MPA - microscopic polyangiitis) presenting with CNS involvement treated in one academic center between 1988 and 2021. Medical database of 255 GPA and MPA vasculitis patients were retrospectively reviewed, and demographics, serological, and clinical features of the patients presenting CNS involvement throughout the disease course were recorded. Comparisons of disease characteristics and long-term outcomes were performed between patients with and without CNS involvement. Results: 27/255 patients (10.5%) had symptoms of CNS involvement associated with the disease. All but one patient had abnormalities confirmed in MRI or CT of the head. Headache (16/28) was the main clinical symptom, followed by vestibular syndrome (11/24), deafness (7/10), motor impairment (9/24) and seizures (4/10). Three patients had psychiatric symptoms and dementia. CNS involvement was characterized by cerebral ischaemic lesions in 19, pachymeningitis in 8, and haemorrhagic lesions in 1 patient. Three patients had thrombosis of brain sinuses and 1 patient had Posterior Reversible Encephalopathy Syndrome (PRES). In 5 of them CNS changes were secondary to infiltrations from skull base. None of our patients had pituitary gland involvement. Two patients had both cerebral and spinal cord pachymeningitis. Lumbar puncture was performed only in one patient. None of the patients had brain biopsy performed. When compared with group without CNS involvement we found only two statistically important differences: patients with CNS involvement were more often cANCA positive and they had more often eye involvement. Conclusions: CNS involvement is severe complication of AAV. Headaches, cANCA positivity and eye involvement are associated with this complication. Disclosures: All Authors declare no disclosures.
Eucera (Rhyteucera) caerulescens Friese 1899
Creators: name: Boustani, Mira
name: Rasmont, Pierre
name: Dathe, Holger H.
name: Ghisbain, Guillaume
name: Kasparek, Max
name: Michez, Denis
name: Müller, Andreas
name: Pauly, Alain
name: Risch, Stefan
name: Straka, Jakub
name: Terzo, Michael
name: Achter, Xavier Van
name: Wood, Thomas J.
name: Nemer, Nabil
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Apidae
Eucera
Eucera caerulescens

description: Eucera (Rhyteucera) caerulescens Friese, 1899
Distribution: EAST MEDITERRANEAN: Cyprus, Near East, Turkey, records from Libya to be confirmed (Risch, pers. comm, 2020)
Literature. Friese (1899): Mount Lebanon, Brumana (and from Mersina, Cyprus), 2–5.IV.1899, some males and females, det. Friese H., leg. Morice F.
Material examined. Bekaa: Kefraya, Horch El Kaser, 992 m, 9.IV.2019, 1♂, leg. Boustani M., coll. MBOU.
Mount Lebanon: Marj Barja, Terbe, 17.IV.2017, 2♀, leg. Boustani M.; Marej Barja, Kaleet El Besten, 358 m, 26.IV.2019, 1♀, 2♂, leg. Boustani M., all coll. MBOU.
N. Lebanon: Arz Tannourine, 1799 m, 6.V.2017, 1♀, leg. Boustani M.; 1800 m, 6.V.2017, 1♀, leg. Boustani M.; 1739 m, 7.VI.2017, 1♀, leg. Boustani M., all coll. MBOU.
Flower record. Fabaceae: Hymenocarpos circinnatus, Trifolium sp.; Geraniaceae: Geranium c. f. rotundifolium.
description: Published as part of Boustani, Mira, Rasmont, Pierre, Dathe, Holger H., Ghisbain, Guillaume, Kasparek, Max, Michez, Denis, Müller, Andreas, Pauly, Alain, Risch, Stefan, Straka, Jakub, Terzo, Michael, Achter, Xavier Van, Wood, Thomas J. & Nemer, Nabil, 2021, The bees of Lebanon (Hymenoptera: Apoidea: Anthophila), pp. 1-146 in Zootaxa 4976 (1) on page 90, DOI: 10.11646/zootaxa.4976.1.1, http://zenodo.org/record/4819018
Eucera (Agatheucera) cinnamomea Alfken 1935
Creators: name: Boustani, Mira
name: Rasmont, Pierre
name: Dathe, Holger H.
name: Ghisbain, Guillaume
name: Kasparek, Max
name: Michez, Denis
name: Müller, Andreas
name: Pauly, Alain
name: Risch, Stefan
name: Straka, Jakub
name: Terzo, Michael
name: Achter, Xavier Van
name: Wood, Thomas J.
name: Nemer, Nabil
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Apidae
Eucera
Eucera cinnamomea

description: Eucera (Agatheucera) cinnamomea Alfken, 1935 *
Distribution: LEVANT: Syria, Lebanon, Jordan, Israel.
Material examined. Mount Lebanon: Alay [Aley], 1.VI.1973, 1♀., coll. AUB.; Maaniye, Dhour El Maaniye, 324 m, 25.V.2019, 4♀; Maaser Al Chouf, 1143 m, 29.V.2019, 1♂, all leg. Boustani M., coll. MBOU.
S. Lebanon: Saidoun, El Mrouj, 29.IV.2017, 2♂, leg. Baghdadi A., coll. SOILS.
Flower records: Asteraceae: Anthemis pauciloba, Cirsium sp.
description: Published as part of Boustani, Mira, Rasmont, Pierre, Dathe, Holger H., Ghisbain, Guillaume, Kasparek, Max, Michez, Denis, Müller, Andreas, Pauly, Alain, Risch, Stefan, Straka, Jakub, Terzo, Michael, Achter, Xavier Van, Wood, Thomas J. & Nemer, Nabil, 2021, The bees of Lebanon (Hymenoptera: Apoidea: Anthophila), pp. 1-146 in Zootaxa 4976 (1) on page 90, DOI: 10.11646/zootaxa.4976.1.1, http://zenodo.org/record/4819018
D1.3 Life Sciences Use Case: Requirements, Scenario Definitions and Initial Evaluation Report
Creators: name: Project Consortium Members
Publisher: name: Zenodo
Year: 2020

description: This deliverable describes the requirements and scenario definitions of the Life Sciences use case. We introduce the requirements of the multiscale model framework, termed PhysiBoSSa, and justify our choice of selection of this framework. Later, we detail the framework’s components: the agent-based, the environment, the signalling network and the cell cycle components. Additionally, we explain how integrating these in a physics-based cell simulator allows us to study different aspects crucial for the development and growth of tumours and how, given the biophysical, biochemical, and biomechanical factors present, multiscale model can help identify the factors that drive a given treatment to be a success or a failure. The Life Sciences scenario includes the study of two drug resistance-related biological models with different cell signalling networks: the first one is a study of different drug regimes using TNF and the second is a study of drug combinations using the AGS gastric cancer cell line. Using these biological models and our PhysiBoSSa, we replicate experimental data of growth profiles of cancer cells treated with different drug regimes. The ultimate goal of this use case is to provide a “virtual laboratory” for studying cancer growth and evolution by using multiscale models of tumour systems. The development of such a framework facilitates the design, test, and optimisation of cancer treatments based on combinations of different drugs and dose scheduling strategies. These simulations are being scaled up by several orders of magnitude by parallelising the code in a hybrid OpenMP-MPI implementation, aiming to scale up simulations of cancer cell 3D spheroids up to a billion cells using high-performance computing. These scaled-up simulations using the Barcelona Supercomputing Center (BSC) MareNostrum4 will incorporate forecasting techniques for various events of interest, as well as techniques to reduce uninformative simulations. Moreover, we present a model exploration technique that allows us to study the structure and hierarchy of the model’s parameters and to evaluate its sensibility to the parameters’ perturbation. All these developments will facilitate the design of different set-ups that tally cancer tumour growth conditions with increased number of cells, altered microenvironmental physical properties, different cell types, as well as, study the interaction between cancer cells and the immune system. Lastly, we present the Initial Evaluation Report from expert users, including the results of INFORE prototype on the available data streams.
D1.2 Initial Agent-Based Model
Creators: name: Project Consortium Members
Publisher: name: Zenodo
Year: 2020

description: This deliverable describes the agent-based model currently used in the Life Science use case of INFORE, the parameters used in its simulation and its HPC implementation. Additionally, we present preliminary results of a model exploration framework that is extremely useful for the study of models’ parameters. The ultimate goal of this use case is to provide a “virtual laboratory” for studying cancer growth and evolution by using multiscale models of tumors. Thus, by integrating a center-based agent model into a multiscale model (MSM) allows us to study different aspects crucial for the development and growth of tumors. Indeed, given the biophysical, biochemical, and biomechanical factors present in these problems, MSM can help identify the factors that drive a given treatment to be a success or a failure. This MSM consists of several components and modules that are hereby detailed and that operate at very different time scales: environment, cells, signaling pathways, and cell cycle behavior. Furthermore, to scale our simulations we need to parallelize our MSM. With that in mind we have started by parallelizing the environment component, which has the smallest time scale. This successful parallelization enables us to address the parallelization of the cells component, a task that is currently ongoing. These scaled-up simulations using the Barcelona Supercomputing Center (BSC) MareNostrum4 will incorporate forecasting techniques for various events of interest. Lastly, we present a model exploration technique that allows us to define the structure and hierarchy of the model’s parameters and to evaluate its sensibility to the parameters’ perturbation. All these developments will facilitate the design of different set-ups that tally cancer tumor growth conditions with increased number of cells, altered microenvironmental physical properties, different cell types, as well as, study the interaction between cancer cells and the immune system.
138. Maladaptive activation of trained immunity in the pathogenesis of Giant Cell Arteritis
Creators: name: Cantoni1, Eleonora
Publisher: name: Zenodo
Year: 2022
Subjects: Vasculitis
ANCA
Abstracts
Giant Cell Arthritis
MPA
GPA
EGPA
Takayasu
IgA vasculitis

description: Background: Giant cell arteritis (GCA) is a large-vessel vasculitis characterized by inflammation of the aorta and cranial arteries, leading to rampant systemic inflammation and irreversible ischemic complications. Macrophage activation and excessive cytokine production are central to the pathogenesis of GCA, as confirmed by infiltration with myeloid cells at arterial biopsy and by the clinical efficacy of cytokine inhibitors (1). However, the mechanism responsible for this chronic inflammatory activation of monocyte/macrophages in GCA remains elusive. Trained immunity (TI) is a pro-inflammatory program induced in monocyte/macrophages upon sensing of some pathogens and characterized by immunometabolic and epigenetic changes, functionally resulting in enhanced cytokine production (2). In this study, we hypothesized that maladaptive activation of TI (i.e. in the absence of infection) may account for the development of detrimental inflammation in GCA. We specifically aimed at determining the mechanistic features of TI in GCA monocytes, and the therapeutic potential of targeting TI for the treatment of GCA. Methods: We adopted a polyfunctional approach (UHPLC-Mass Spectrometry, chromatin immunoprecipitation PCR, ATAC sequencing, RNA sequencing, ELISA assays) to compare monocytes from a large cohort clinically active GCA patients (i.e. at diagnosis or during flares) to age- and sex-matched healthy controls (HD). Results: Metabolomics studies revealed a profound immunometabolic rewiring in GCA monocytes, consistent with activation of TI (i.e. increased glycolysis, glutaminolysis through the TCA cycle, and cholesterol synthesis) (3). Epigenetic studies revealed changes in the epigenetic landscape, including H3K27Ac in enhancers of genes encoding cytokines (3), as well as increased accessibility of chromatin regions encoding for pro-inflammatory genes and effector immune mechanisRNA sequencing studies confirmed enhanced transcription of pro-inflammatory genes and pathways, both at baseline and following stimulation with LPS. ELISA assays revealed a significant increase in LPS-induced inflammatory cytokine production in GCA monocytes compared to HD, which represents the functional hallmark of TI. Furthermore, immunometabolic inhibition effectively dampened cytokine production by GCA monocytes (4). Conclusions: Altogether, our findings indicate that deregulated TI is involved in the pathogenesis of GCA and identify druggable targets for alternative and/or complementary pharmacological treatment of GCA. Disclosures: The authors declare no competing financial interests.
Eucera (Stilbeucera) clypeata Erichson 1835
Creators: name: Boustani, Mira
name: Rasmont, Pierre
name: Dathe, Holger H.
name: Ghisbain, Guillaume
name: Kasparek, Max
name: Michez, Denis
name: Müller, Andreas
name: Pauly, Alain
name: Risch, Stefan
name: Straka, Jakub
name: Terzo, Michael
name: Achter, Xavier Van
name: Wood, Thomas J.
name: Nemer, Nabil
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Apidae
Eucera
Eucera clypeata

description: Eucera (Stilbeucera) clypeata Erichson, 1835 *
Distribution: WEST PALAEARCTIC: North Africa, Europe to Central Asia.
Material examined. Mount Lebanon: Marj Barja, Terbe, 17.IV.2017, 1♂, leg. Boustani M., coll. MBOU.
N. Lebanon: South of Jairoun, 1648m, 23.V.2012, 2♀, leg. Kasparek M.; Donnieh, Sfiri, 245 m, 27.V.2012, 1♀, leg. Kasparek M.; Donnieh, Nemrud, 245 m, 28.V.2012, 1♀, leg. Kasparek M., all coll. OÖLM; Hadath El Jebbe, Wadi Al Fouar, 1553 m, 21.V.2018, 1♂, leg. Boustani M.; Hadath El Jebbe, Wadi Al Fouar, 1553 m, 6.VI.2018, 1♀, leg. Boustani M.; Tannourine El Tahta, Mar Boutrous, 1207 m, 31.V.2019, 1♀, leg. Boustani M.; Hadath El Jebbe, Al Fouar, 1529 m, 7.VI.2019, 2♀, leg. Boustani M., Mouawad G.; 27.VI.2019, 1♀, leg. Boustani M., Mouawad G., all coll. MBOU.
Flower records. Fabaceae: Lotus gebelia libanoticus, Vicia tenuifolia; Lamiaceae: Phlomis chrysophylla.; Malvaceae: Alcea apterocarpa.
description: Published as part of Boustani, Mira, Rasmont, Pierre, Dathe, Holger H., Ghisbain, Guillaume, Kasparek, Max, Michez, Denis, Müller, Andreas, Pauly, Alain, Risch, Stefan, Straka, Jakub, Terzo, Michael, Achter, Xavier Van, Wood, Thomas J. & Nemer, Nabil, 2021, The bees of Lebanon (Hymenoptera: Apoidea: Anthophila), pp. 1-146 in Zootaxa 4976 (1) on pages 90-91, DOI: 10.11646/zootaxa.4976.1.1, http://zenodo.org/record/4819018
D1.1 Life Sciences Use Case: Initial Requirements and Scenario Definitions
Creators: name: Project Consortium Members
Publisher: name: Zenodo
Year: 2019

description: This deliverable describes the requirements and scenario definitions of the biological use case in accordance with expert users’ questionnaires. By using a Boolean model of carcinoma cell lines (AGS) and a lattice-free physics-based cell simulator for 3D multicellular modelling, PhysiBoSS, we aim to replicate experimental data of growth profiles of cancer cells treated with different drug regimes. The ultimate goal of this use case is to provide a "virtual laboratory" for studying cancer growth and evolution by using multi-scale models of tumour systems. The development of such a framework will facilitate the design, test, and optimization of cancer treatments based on combinations of different drugs and dose scheduling strategies. In our simulations, we will explore two alternative geometries for cell arrangement: i) one-cell-thick 2D monolayers, representing cells growing in a plate such as those observed in in-vitro cell cultures; and ii) 3D spheroids, representing cells growing in three-dimensional space, an arrangement that resembles cancer cells growing in-vivo. These simulations will be scaled up by several orders of magnitude using the Barcelona Supercomputing Center (BSC) MareNostrum4 allowing the incorporation of forecasting techniques for various events of interest. Moreover, interactive learning techniques will be used to assist the calibration of such in-silico models. In particular, we aim to scale up simulations of cancer cell 3D spheroids from 5,000 up to 500,000 cells using high-performance computing. This scenario will allow the design of different set-ups that tally cancer tumour growth conditions with increased number of cells, altered microenvironmental physical properties, different cell types, as well as to study the interaction between cancer cells and the immune system. In addition, this will allow the consideration of different simulations’ set-ups beyond cancer tumour growth such as in-vitro streak experiments, microfluidic designs, among others.
Eucera (Eucera) cypria Alfken 1933
Creators: name: Boustani, Mira
name: Rasmont, Pierre
name: Dathe, Holger H.
name: Ghisbain, Guillaume
name: Kasparek, Max
name: Michez, Denis
name: Müller, Andreas
name: Pauly, Alain
name: Risch, Stefan
name: Straka, Jakub
name: Terzo, Michael
name: Achter, Xavier Van
name: Wood, Thomas J.
name: Nemer, Nabil
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Apidae
Eucera
Eucera cypria

description: Eucera (Eucera) cypria Alfken, 1933 * (fig. 22.2)
Distribution: EAST MEDITERRANEAN: Cyprus, East Aegean Island to Iran and Israel.
Local distribution fig. 15.15
Unpublished records. GBIF 2021, SEMC: Mount Lebanon: Monteverde, nr Mansourieh, 350 m, 28.IV.1996, 1♀, det. Baker D., leg. Roche C.G.
Material examined. Bekaa: Qaraoun, 792 m, 24. III.2013, 5♂, leg. Kasparek M., coll. OÖLM.
Mount Lebanon: Beit Meri, 19.IV.0000, 1♀, leg. Manassah R.; Fanar, 11.III.1965, 1♀, 2♂; Locality Unknown, 11.IV.1975, 2♀, 1♂., all coll. USEK; Daychounieh, Nahr Beirut Climbing Site, 133 m, 3.IV.2017, 6♀, 5♂, leg. Boustani M.; 27.IV.2017, 1♂, leg. Boustani M., all coll. MBOU; Falougha, 1478 m, 27.IV.2019, 2♂, leg. Boustani M., coll. PRAS.
N. Lebanon: Hadath El Jebbe, Wadi Al Fouar, 1553 m, 4.III.2018, 1♀, 1♂, leg. Boustani M., coll. MBOU.Additional 23♀ and 21♂, from 18 records, collected between 24.III.2017 and 11.V.2019, from Tannourine El Tahta, Arz Tannourine, Fehta, and Hadath El Jebbe.
S. Lebanon: Hlaliyeh, 11.IV.1975, 1♂; Saidoun, El Mrouj, 26. III.2017, 1♀, leg. Baghdadi A.; Saidoun, Lavender Garden, 4. III.2018, 2♂, leg. Baghdadi A.; Saidoun, 5. III.2018, 1♂, leg. Baghdadi A.; 24. III.2019, 1♂, leg. Baghdadi A., all coll. SOILS.
Flower records. Boraginaceae: Anchusa hybrida, Solenanthus stamineus; Fabaceae: Vicia narbonensis, Vicia sericocarpa; Lamiaceae: Lavandula x intermedia.
description: Published as part of Boustani, Mira, Rasmont, Pierre, Dathe, Holger H., Ghisbain, Guillaume, Kasparek, Max, Michez, Denis, Müller, Andreas, Pauly, Alain, Risch, Stefan, Straka, Jakub, Terzo, Michael, Achter, Xavier Van, Wood, Thomas J. & Nemer, Nabil, 2021, The bees of Lebanon (Hymenoptera: Apoidea: Anthophila), pp. 1-146 in Zootaxa 4976 (1) on page 91, DOI: 10.11646/zootaxa.4976.1.1, http://zenodo.org/record/4819018
Preregistration of replication and extension study
Creators: name: Stahl, Christoph
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences

description: In humans, attitudes can be learned when initially neutral stimuli (Conditioned Stimuli, CSs), such as faces of unfamiliar persons or brand names, are merely presented together (i.e., paired) with valent stimuli (Unconditioning Stimuli, USs), for example beautiful faces or pleasant scene images (Hofmann, De Houwer, Perugini, Baeyens, & Crombez, 2010). It is debated whether this phenomenon—evaluative conditioning (EC)—can occur unconsciously. While there is little evidence supporting EC in the absence of awareness during learning (for review, see Corneille & Stahl, 2019), some studies report EC in the absence of participants’ memory of the CS-US pairing at the time of retrieval (e.g., Hütter, Sweldens, Stahl, Unkelbach, & Klauer, 2012; Waroquier, Abadie, & Dienes, 2020). In a recent study, Stahl, Aust, Mierop, Béna, and Corneille (2020) used an improved assessment procedure and came to the opposite conclusion: In their study, whenever participants reported not remembering the valence of the US, they did not show EC effects. This finding suggests that EC and memory are strongly related, and that there is no EC in the absence of memory. Here we aim at replicating this finding with a larger sample. A second goal of this study is to extend the study of the EC-memory relation by asking, reversely, whether there is memory in the absence of attitudes towards the CS. If EC and memory are tightly related, then participants should always have acquired an attitude whenever they remember a CS-US pairing. If, on the other hand, CS-US pairing memory is merely a precondition for establishing an attitude, one would expect to find cases of memory without learned attitudes.
An investigation of the vocabulary representative of postgraduate International Law texts
Creators: name: Kemp, Jenny
Publisher: name: University of Leicester
Year: 2022
Subjects: Uncategorized

description: The reading requirements for postgraduate (LLM) International Law courses are challenging, particularly for second language students. As vocabulary is a key component in reading ability, this research aimed to help these students by identifying a discipline-specific vocabulary core of words essential for LLM reading. To this end, the 1.98-million word DSVC-IL corpus was compiled from 12 domains of International Law, comprised of 401 5000-word samples from 21 genres across three communicative functions (prescriptive, descriptive and hybrid). The DSVC-IL corpus is demonstrated to adequately represent the target domain of LLM reading, and this is confirmed by Law experts. A Single Word (SW) List was extracted on the basis of frequency, range, keyness and dispersion, with the BNC written academic component as a reference corpus, and using Kilgarriff’s (2009) Simple Math statistic for keyness, and Savický and Hlaváčová’s (2002) Average Reduced Frequency (ARF) to measure evenness of distribution. This study demonstrates that the SW List of 1026 flemmas is linguistically representative of the target domain. Moreover, a comparison of the ranked ARF scores of list items in two randomly-split halves showed items are evenly distributed (rs=.98, p<.000). The SW List provides 26.37% coverage of the DSVC-IL, and 23.87% coverage of other texts sampled from the domain. The study also demonstrates that while the list contains words classed elsewhere as general English or general academic, many are discipline-specific in their meaning, usage and/or lexical patterning. For instance, 15% of the items are shown to have a law-specific intra- or intertextual function, the knowledge of which would greatly benefit student readers. This research makes an important contribution to our understanding of International Law vocabulary, providing a sound foundation for the design of EALP teaching materials. Furthermore, it offers a new method for establishing and reporting representativeness, through the use of an innovative Representativeness Argument adapted from Toulmin (1958/2003).
355. Retrospective observational study on the long-term safety of Rituximab in ANCA associated Vasculitis (RIVAS)
Creators: name: King1, Maria
Publisher: name: Zenodo
Year: 2022
Subjects: Vasculitis
ANCA
Abstracts
Giant Cell Arthritis
MPA
GPA
EGPA
Takayasu
IgA vasculitis

description: Background/ Objectives: To assess the long-term safety of rituximab in a retrospective, secondary use-of-data study in patients with Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA) by (a) estimating the incidence of serious adverse events (SAEs) and (b) comparing those incidence rates between a rituximab-treated cohort and a control cohort treated with other available therapies. Methods: Patients in both cohorts were followed by review of their medical records from baseline to study end (30 Sept 2018): baseline was defined by the date of first rituximab treatment since 2003 (rituximab cohort) and time of first disease flare/diagnosis since 2003 (controls). Details of all documented SAEs and adverse events of specific interest including infusion related events, hypogammaglobulinemia or neutropenia were recorded every 12-18 months. Primary endpoint (time to first SAE) is presented along with composite endpoints and repeated event analysis using survival models and regression analyses. Results: Overall, 392 patients (77% with GPA and 23% with MPA) were included in the study (247 rituximab-exposed patients, 145 control patients) with a total of 2,217 patient years (PY, mean study duration 5.7 years). The study population was 52% female and 93% white-British, with a mean ± SD age of 60.9 ± 16.3 years. Rituximab patients received a mean of 7.2 infusion doses (ranging from 1 to 23). Significant baseline imbalances between the two cohorts were found. The rituximab cohort had greater levels of comorbidities, a more complex medication history and longer mean disease duration ± SD at baseline: 54.7 months ±70.9 compared to 33.2 months ± 63.8 (control). A total of 557 events occurred in 164 patients of the rituximab cohort (66.4%) and 185 events in 78 control patients (53.8%). Cohort imbalances will be accounted for by covariate analysis. Estimated incidence rates for infections, cardiovascular events and malignancies will be presented by cohort. Conclusions: With a long follow-up period and control cohort comparison, the findings of the RIVAS study will provide a good indication on long-term safety of Rituximab in patients with Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA). Disclosures: David Jayne’s disclosures of commercial conflicts for companies with marketed products for 2021 are: Astra-Zeneca, Aurinia, B, Boehringer-Ingelheim, GSK, Janssen, Novartis, Roche/Genentech, Takeda & Vifor.The RIVAS study was funded by Hoffmann la Roche. We also acknowledge Simon Bond & Marianna Nodale of Cambridge Clinical Trials Unit.
Eucera (Eucera) dalmatica Lepeletier 1841
Creators: name: Boustani, Mira
name: Rasmont, Pierre
name: Dathe, Holger H.
name: Ghisbain, Guillaume
name: Kasparek, Max
name: Michez, Denis
name: Müller, Andreas
name: Pauly, Alain
name: Risch, Stefan
name: Straka, Jakub
name: Terzo, Michael
name: Achter, Xavier Van
name: Wood, Thomas J.
name: Nemer, Nabil
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Apidae
Eucera
Eucera dalmatica

description: Eucera (Eucera) dalmatica Lepeletier, 1841 *
Distribution: WEST PALAEARCTIC: East Mediterranean, Near East, Turkey, SE Europe to SE France, S Spain.
Material examined. Bekaa: Der El Ahmar, 995 m, 3.VII.2019, 2♀, leg. Boustani M.
Mount Lebanon: Bhmadoun, 23.V.1981, 1♂, leg. Mireille K., coll. AUB.
N. Lebanon: Qanat, Qornet Dammouaa, 1231 m, 31.V.2017, 1♀, leg. Rasmont P., coll. PRAS.; Arz Bcharre, Reforestation Area, 1973 m, 2.VII.2019, 1♀, leg. Boustani M., coll. MBOU; Qanat, Qornet Dammouaa, 1197 m, 5.VII.2019, 1♀, leg. Van Achter X., coll. XVA.
Flower records. Boraginaceae: Echium italicum, Vicia tenuifolia.
description: Published as part of Boustani, Mira, Rasmont, Pierre, Dathe, Holger H., Ghisbain, Guillaume, Kasparek, Max, Michez, Denis, Müller, Andreas, Pauly, Alain, Risch, Stefan, Straka, Jakub, Terzo, Michael, Achter, Xavier Van, Wood, Thomas J. & Nemer, Nabil, 2021, The bees of Lebanon (Hymenoptera: Apoidea: Anthophila), pp. 1-146 in Zootaxa 4976 (1) on page 91, DOI: 10.11646/zootaxa.4976.1.1, http://zenodo.org/record/4819018
Prima traccia per una ricerca su “Dopo il Tardoantico: la voce dei giuristi nella costruzione dei codici e nella formazione dei giovani”. Giovanni Nomofilace
Creators: name: Biccari, Maria Luisa
Publisher: name: Studi Urbinati, A - Scienze giuridiche, politiche ed economiche
Year: 2018

description: Attraverso un’analisi delle voci dei giuristi che si leggono negli scholia ai Basilici, il presente lavoro si propone di considerare più attentamente l’opera legislativa dell’imperatore Basilio il Macedone e Leone VI il Saggio. In particolare l’esame degli scolii riferibili a Giovanni Nomofilace (variamente indicato come Giovanni, o Giovanni Nomofilace, o Nomofilace) consente di sviluppare una prima serie di considerazioni relative all’identità degli scoliasti, al loro pensiero e alle loro opere.

Through an analysis of the voices of jurists that appear in the scholia to the Basilica, this paper aims to examine the legislative work of the Macedonian emperors Basil I and Leo VI the Wise. In particular, the scholia of Giovanni Nomofilace (also referred as “Giovanni”, “Giovanni Nomofilace”, or “Nomofilace”) allows to develop some considerations concerning the identity of the scoliasts and their works.
description: Studi Urbinati, A - Scienze giuridiche, politiche ed economiche, V. 68, N. 3-4 (2017)
Mafia in Riviera. ‘Ndrangheta, Camorra, Cosa nostra: origine e radicamenti della mafia italiana
Creators: name: Bondi, Alessandro
Publisher: name: Studi Urbinati, A - Scienze giuridiche, politiche ed economiche
Year: 2018

description: ‘Ndrangheta, Camorra, Cosa nostra. Studio che parte da fatti, descrivendo fenomeni, valutando la risposta criminale vergata in norme. Mafie come imprese criminali di cui si mostrano definizioni, cause, difese che conservano le garanzie proprie di uno Stato di diritto. Non manca una ‘verifica sul campo’, cercando radicamenti lontani dai luoghi di origine di queste forme di criminalità organizzata.

‘Ndrangheta, Camorra, Cosa nostra. A study that starts from facts, describing phenomena, evaluating the criminal response framed in norms. Mafia as criminal enterprises whose definitions, causes, defenses preserve the guarantees of a rule of law. There is no lack of a ‘field check’, looking for roots far from the area of origin of these types of organized crime.
description: Studi Urbinati, A - Scienze giuridiche, politiche ed economiche, V. 68, N. 3-4 (2017)
Eucera (Hetereucera) ebmeri Risch 1999
Creators: name: Boustani, Mira
name: Rasmont, Pierre
name: Dathe, Holger H.
name: Ghisbain, Guillaume
name: Kasparek, Max
name: Michez, Denis
name: Müller, Andreas
name: Pauly, Alain
name: Risch, Stefan
name: Straka, Jakub
name: Terzo, Michael
name: Achter, Xavier Van
name: Wood, Thomas J.
name: Nemer, Nabil
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Apidae
Eucera
Eucera ebmeri

description: Eucera (Hetereucera) ebmeri Risch, 1999 *
Distribution: EAST MEDITERRANEAN: East Aegean Islands to Turkey, Jordan and Israel.
Material examined. Mount Lebanon: Marej Barja, Terbe, 442 m, 24. III.2019, 1♀, leg. Boustani M., coll. MBOU. N. Lebanon: Tannourine El Tahta, Wadi Ain El Raha, 900 m, 24. III.2017, 4♂; 18.IV.2017, 2♀; Tannourine El Tahta, Al Mahbase, 893 m, 12.IV.2019, 1♂, all leg. Boustani M., all coll. MBOU.
S. Lebanon: Saidoun, 3. III.2018, 1♂, leg. Baghdadi A., coll. SOILS.
Flower records. Fabaceae: Trifolium clypeatum, Vicia sericocarpa.
description: Published as part of Boustani, Mira, Rasmont, Pierre, Dathe, Holger H., Ghisbain, Guillaume, Kasparek, Max, Michez, Denis, Müller, Andreas, Pauly, Alain, Risch, Stefan, Straka, Jakub, Terzo, Michael, Achter, Xavier Van, Wood, Thomas J. & Nemer, Nabil, 2021, The bees of Lebanon (Hymenoptera: Apoidea: Anthophila), pp. 1-146 in Zootaxa 4976 (1) on page 91, DOI: 10.11646/zootaxa.4976.1.1, http://zenodo.org/record/4819018
La superación del indulto como mecanismo de individualización de la pena
Creators: name: Carracedo Carrasco, Eva
Publisher: name: Studi Urbinati, A - Scienze giuridiche, politiche ed economiche
Year: 2018

description: Nel corso della sua evoluzione, la grazia («indulto» in Spagna) ha svolto numerose funzioni. Di queste, si evidenzia il suo essere strumento che permette, nel caso vi siano caratteri di eccezionalità, la conciliazione tra esigenze di giustizia formale e materiale secondo il principio di proporzione. L’analisi valuta la necessità di mantenere l’istituto della grazia per rispondere a tale funzione. A tal fine, si sono individuate le ragioni storiche che giustificavano il suo utilizzo; le disfunzioni legate alla sua applicazione; i meccanismi alternativi offerti dal diritto penale moderno per realizzare la stessa funzione: individualizzazione della pena da parte dell’organo giudiziario; istituti di flessibilizzazione della esecuzione della pena; possibilità di modifica o deroga della legge o questioni di costituzionalità.

The uses assigned to the figure of pardon throughout its history have been diverse. Key amongst them is its conception as a mechanism for individualizing the punishment, its implementation as an instrument of proportionality that allows, in a case characterized by its exceptionality, the conciliation between formal and material justice. The article starts from this reality to call into question that the institution of pardon should be maintained to satisfy that end. In particular, it identifies the historical reason that justified its use, it warns of the dysfunctions that its role generates and it examines the different mechanisms available within a modern Criminal Law to perform that function (individualization of punishment by the judge, flexible institutions while executing the ruling, possibility of modification or repeal of the law or raising an unconstitutionality exception). From these reflections it is inferred, in conclusion, the overcoming of pardon as a mechanism for individualizing the punishment.
description: Studi Urbinati, A - Scienze giuridiche, politiche ed economiche, V. 68, N. 3-4 (2017)
A multi‐criteria decision‐making approach for assembling optimal powertrain technology portfolios in low GHG emission environments
Creators: name: Kellner, Florian
name: Lienland, Bernhard
name: Utz, Sebastian
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: automotive sector, decision-support system, industrial ecology, portfolio optimization, power-train technologies, technology selection
subject: 330 Wirtschaft

description: Environmental regulations force car manufacturers to renew the powertrain technology portfolio offered to the customer to comply with greenhouse gas (GHG) emission targets. In turn, automotive companies face the task of identifying the “right” powertrain technology portfolio consisting of, for example, internal combustion engines and electric vehicles, because the selection of a particular powertrain technology portfolio affects different company targets simultaneously. What makes this decision even more challenging is that future market shares of the different technologies are uncertain. Our research presents a new decision‐support approach for assembling optimal powertrain technology portfolios while making decision‐makers aware of the trade‐offs between the achievable profit, the achievable market share, the market share risk, and the GHG emissions generated by the selected vehicle fleet. The proposed approach combines “a posteriori” decision‐making with multi‐objective optimization. In an application case, we feed the outlooks of selected market studies into the proposed decision‐support system. The result is a visualization and analysis of the current real‐world decision‐making problem faced by many automotive companies. Our findings indicate that for the proposed GHG restriction at work in 2030 in the European Union, no optimal powertrain technology portfolio with less than 35% of vehicles equipped with an electric motor exists.
Chemoenzymatic Synthesis of a New Germacrene Derivative Named Germacrene F
Creators: name: Struwe, Henry
name: Droste, Jörn
name: Dhar, Dipendu
name: Davari, Mehdi D.
name: Kirschning, Andreas
Publisher: name: Weinheim : Wiley-VCH
Year: 2023
Subjects: subject: biotransformation
subject: enzyme promiscuity
subject: germacrene
subject: sesquiterpene cyclases
subject: sesquiterpenes
subject: Dewey Decimal Classification::500 | Naturwissenschaften::570 | Biowissenschaften, Biologie
subject: Dewey Decimal Classification::500 | Naturwissenschaften::540 | Chemie

description: The new farnesyl pyrophosphate (FPP) derivative with a shifted olefinic double bond from C6-C7 to C7-C8 is accepted and converted by the sesquiterpene cyclases protoilludene synthase (Omp7) as well as viridiflorene synthase (Tps32). In both cases, a so far unknown germacrene derivative was found to be formed, which we name “germacrene F”. Both cases are examples in which a modification around the central olefinic double bond in FPP leads to a change in the mode of initial cyclization (from 1→11 to 1→10). For Omp7 a rationale for this behaviour was found by carrying out molecular docking studies. Temperature-dependent NMR experiments, accompanied by NOE studies, show that germacrene F adopts a preferred mirror-symmetric conformation with both methyl groups oriented in the same directions in the cyclodecane ring.
Eucera (Pileteucera) fasciata Risch 1999
Creators: name: Boustani, Mira
name: Rasmont, Pierre
name: Dathe, Holger H.
name: Ghisbain, Guillaume
name: Kasparek, Max
name: Michez, Denis
name: Müller, Andreas
name: Pauly, Alain
name: Risch, Stefan
name: Straka, Jakub
name: Terzo, Michael
name: Achter, Xavier Van
name: Wood, Thomas J.
name: Nemer, Nabil
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Apidae
Eucera
Eucera fasciata

description: Eucera (Pileteucera) fasciata Risch, 1999 *
Distribution: WEST PALAEARCTIC: Eastern Mediterranean, SE Europe to Iran and Israel.
Material examined. Bekaa: Ainata, 1556 m, 30.V.2017, 2♂, leg. Boustani M., Rasmont P.
N. Lebanon: Hadath El Jebbe, Cedar Forest, 1639 m, 1♂, leg. Boustani M., all coll. MBOU.
Flower record. Asteraceae: Serratula pusilla.
description: Published as part of Boustani, Mira, Rasmont, Pierre, Dathe, Holger H., Ghisbain, Guillaume, Kasparek, Max, Michez, Denis, Müller, Andreas, Pauly, Alain, Risch, Stefan, Straka, Jakub, Terzo, Michael, Achter, Xavier Van, Wood, Thomas J. & Nemer, Nabil, 2021, The bees of Lebanon (Hymenoptera: Apoidea: Anthophila), pp. 1-146 in Zootaxa 4976 (1) on page 91, DOI: 10.11646/zootaxa.4976.1.1, http://zenodo.org/record/4819018
Eucera (Atopeucera) friesei Risch 2003
Creators: name: Boustani, Mira
name: Rasmont, Pierre
name: Dathe, Holger H.
name: Ghisbain, Guillaume
name: Kasparek, Max
name: Michez, Denis
name: Müller, Andreas
name: Pauly, Alain
name: Risch, Stefan
name: Straka, Jakub
name: Terzo, Michael
name: Achter, Xavier Van
name: Wood, Thomas J.
name: Nemer, Nabil
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Apidae
Eucera
Eucera friesei

description: Eucera (Atopeucera) friesei Risch, 2003 *
Distribution: EAST MEDITERRANEAN: south-eastern Turkey, Syria Jordan Israel.
Material examined. Bekaa: Qaraoun, 792 m, 24. III.2013, 1♂, leg. Kasparek M., coll. OÖLM.
S. Lebanon: Saidoun, 3. III.2018, 1♂, leg. Baghdadi A., coll. SOILS.
description: Published as part of Boustani, Mira, Rasmont, Pierre, Dathe, Holger H., Ghisbain, Guillaume, Kasparek, Max, Michez, Denis, Müller, Andreas, Pauly, Alain, Risch, Stefan, Straka, Jakub, Terzo, Michael, Achter, Xavier Van, Wood, Thomas J. & Nemer, Nabil, 2021, The bees of Lebanon (Hymenoptera: Apoidea: Anthophila), pp. 1-146 in Zootaxa 4976 (1) on page 91, DOI: 10.11646/zootaxa.4976.1.1, http://zenodo.org/record/4819018