cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Metadesmolaimus zhanggi sp. nov. (Nematoda: Xyalidae) from East China Sea, with a pictorial key to Metadesmolaimus species
Creators: name: GUO, Yu-Qing
name: CHEN, Yu-Zhen
name: LIU, Meng-Di
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2016

description: A new species of the nematode genus Metadesmolaimus Schuurmans Stekhoven, 1935 is described from intertidal sands in Zhangzhou City, Fujian province, East China Sea. Metadesmolaimus zhanggi sp. nov. is morphologically similar to M. gelana Warwick & Platt, 1973 and M. elegans Gagarin, 2013, but can be easily distinguished by six outer labial sensillae jointed and the whole region of pharynx with numerous somatic setae of various lengths. A pictorial key to the valid species of Metadesmolaimus Schuurmans Stekhoven, 1935 is given.
Conformation Changes, N-terminal Involvement, and cGMP Signal Relay in the Phosphodiesterase-5 GAF Domain
Creators: name: Robinson, Howard
name: Ke, Hengming
name: Wang, Huanchen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The activity of phosphodiesterase-5 (PDE5) is specific for cGMP and is regulated by cGMP binding to GAF-A in its regulatory domain. To better understand the regulatory mechanism, x-ray crystallographic and biochemical studies were performed on constructs of human PDE5A1 containing the N-terminal phosphorylation segment, GAF-A, and GAF-B. Superposition of this unliganded GAF-A with the previously reported NMR structure of cGMP-bound PDE5 revealed dramatic conformational differences and suggested that helix H4 and strand B3 probably serve as two lids to gate the cGMP-binding pocket in GAF-A. The structure also identified an interfacial region among GAF-A, GAF-B, and the N-terminal loop, which may serve as a relay of the cGMP signal from GAF-A to GAF-B. N-terminal loop 98–147 was physically associated with GAF-B domains of the dimer. Biochemical analyses showed an inhibitory effect of this loop on cGMP binding and its involvement in the cGMP-induced conformation changes.
First record from the Tunisian coast of the rare species, snake blenny Parophidion vassali (Osteichthyes: Ophidiidae)
Creators: name: CAPAPÉ, Christian
name: RAFRAFI-NOUIRA, Sihem
name: EL KAMEL-MOUTALIBI, Olfa
name: BOUMAÏZA, Moncef
name: CASADEVALL, Margarida
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2016

description: Parophidion vassali (Müller, 1810) is recorded for the first time in Tunisian waters. The specimen is shortly described including morphometric measurements and meristic counts. Its distribution in the area and in the Mediterranean Sea is commented and discussed.
title: Primary neuroendocrine carcinoma of the breast–a rare diagnosis in the breast. A review of imaging and histopathology findings of a patient
Creators: name: Kaur, Shaleen
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Breast
subject: Mammography
subject: CT
subject: Ultrasound
subject: Biopsy
subject: Cancer

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: Primary neuroendocrine carcinoma of the breast (NECB) is a very rare type of breast carcinoma whichtends to behave aggressively, andaccounts for approximately 1% of all breast carcinoma [1,2]. Definitive diagnosis of primary NECB is made by...
Dual Modes of Interaction between XRCC4 and Polynucleotide Kinase/Phosphatase: IMPLICATIONS FOR NONHOMOLOGOUS END JOINING
Creators: name: Ramsden, Dale A.
name: Fang, Shujuan
name: Fanta, Mesfin
name: Lu, Meiling
name: Zolner, Angela E.
name: Mani, Rajam S.
name: Tahbaz, Nasser
name: Litchfield, David W.
name: Weinfeld, Michael
name: Yu, Yaping
name: Lees-Miller, Susan P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: XRCC4 plays a crucial role in the nonhomologous end joining (NHEJ) pathway of DNA double-strand break repair acting as a scaffold protein that recruits other NHEJ proteins to double-strand breaks. Phosphorylation of XRCC4 by protein kinase CK2 promotes a high affinity interaction with the forkhead-associated domain of the end-processing enzyme polynucleotide kinase/phosphatase (PNKP). Here we reveal that unphosphorylated XRCC4 also interacts with PNKP through a lower affinity interaction site within the catalytic domain and that this interaction stimulates the turnover of PNKP. Unexpectedly, CK2-phosphorylated XRCC4 inhibited PNKP activity. Moreover, the XRCC4·DNA ligase IV complex also stimulated PNKP enzyme turnover, and this effect was independent of the phosphorylation of XRCC4 at threonine 233. Our results reveal that CK2-mediated phosphorylation of XRCC4 can have different effects on PNKP activity, with implications for the roles of XRCC4 and PNKP in NHEJ.
title: Hypotension and the abdominal CT
Creators: name: Delaney, Francis
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Abdomen
subject: Trauma
subject: CT
subject: CT-Angiography
subject: Contrast agent-intravenous
subject: Contrast agent-oral
subject: Embolisation
subject: Haemorrhage
subject: Trauma
subject: Ischaemia / Infarction

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: To explore the evolving role of abdominal computed tomography (CT) in the evaluation of hypotensive patients To recognize the features of hypotension on abdominal CT, and understand how their correlation with clinical hypoperfusion can predict...
title: A case series of primary thoracic cancers incidentally detected on CT attenuation correction images in myocardial perfusion scintigraphy
Creators: name: Delaney, Francis
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Nuclear medicine
subject: Lung
subject: Oncology
subject: SPECT-CT
subject: Diagnostic procedure
subject: Cancer

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: To describe the potential for incidental findings on CT attenuation correction (CTAC) images during myocardial perfusion scintigraphy (MPS) To illustrate a case series of primary thoracic malignancies first detected as an incidental finding on CTAC...
Additional file 5 of Revascularization outcomes in diabetic patients presenting with acute coronary syndrome with non-ST elevation
Creators: name: Ram, Eilon
name: Fisman, Enrique Z.
name: Tenenbaum, Alexander
name: Iakobishvili, Zaza
name: Peled, Yael
name: Raanani, Ehud
name: Sternik, Leonid
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology
subject: Science Policy
subject: Hematology
subject: 60506 Virology

description: Additional file 5: Figure S4. Overall 10-year survival curves by revascularization strategy among subgroup of male patients. CABG, Coronary artery bypass graft; PCI, Percutaneous coronary intervention.
Blue crab Callinectes sapidus Rathbun, 1896 continues invasion: first case of entering into freshwater ecosystem in the Mediterranean (Nature Park Vransko Lake, Adriatic Sea)
Creators: name: ŽUPAN, Ivan
name: KARAGA, Antonio
name: ŠARIĆ, Tomislav
name: KANSKI, Danijel
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2016

description: Three specimens of the adult blue crab (Callinectes sapidus) were caught inside the Nature Park Vransko Lake in May 2013, during a regular monitoring of ichtyofauna. All individuals were males and can be considered large. After the initial discovery, trap nets were placed on several locations within the lake, but no blue crabs were caught afterwards up to this date. Regardless, due to the invasive nature of this species and potential negative impact on indigenous species, further monitoring of the blue crab population in the Mediterranean and especially within the protected areas should gain more interest and support.
Effect of Vitamin K-dependent Protein Precursor Propeptide, Vitamin K Hydroquinone, and Glutamate Substrate Binding on the Structure and Function of γ-Glutamyl Carboxylase
Creators: name: Straight, David L.
name: Mutucumarana, Vasantha P.
name: Stafford, Darrel W.
name: Jorgenson, James W.
name: Higgins-Gruber, Shannon L.
name: Lin, Pen Jen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The γ-glutamyl carboxylase utilizes four substrates to catalyze carboxylation of certain glutamic acid residues in vitamin K-dependent proteins. How the enzyme brings the substrates together to promote catalysis is an important question in understanding the structure and function of this enzyme. The propeptide is the primary binding site of the vitamin K-dependent proteins to carboxylase. It is also an effector of carboxylase activity. We tested the hypothesis that binding of substrates causes changes to the carboxylase and in turn to the substrate-enzyme interactions. In addition we investigated how the sequences of the propeptides affected the substrate-enzyme interaction. To study these questions we employed fluorescently labeled propeptides to measure affinity for the carboxylase. We also measured the ability of several propeptides to increase carboxylase catalytic activity. Finally we determined the effect of substrates: vitamin K hydroquinone, the pentapeptide FLEEL, and NaHCO3, on the stability of the propeptide-carboxylase complexes. We found a wide variation in the propeptide affinities for carboxylase. In contrast, the propeptides tested had similar effects on carboxylase catalytic activity. FLEEL and vitamin K hydroquinone both stabilized the propeptide-carboxylase complex. The two together had a greater effect than either alone. We conclude that the effect of propeptide and substrates on carboxylase controls the order of substrate binding in such a way as to ensure efficient, specific carboxylation.
L'OVOGENÈSE CHEZ NEROPHIS LUMBRICIFORMIS (PENNANT, 1776). LE CYCLE SEXUEL
Creators: name: LAHAYE, Jacqueline
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1971

description: In Nerophis lumbriciformis, females have an active share in reproduction during a great part of the year from January to September. Throughout this period, each female is laying eggs successively several times and, in the ovary, oocytes are divided in so much stages of development. Before sexual rest, from May, not any new group of oocytes is growing.
On the other hand, from September-October, groups of small oocytes are beginning to ripen. Thus females will be ready to lay eggs in next January.
On dimension reduction in Gaussian filters
Creators: name: Solonen, Antti
name: Cui, Tiangang
name: Hakkarainen, Janne
name: Marzouk, Youssef
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computation (stat.CO)
subject: Probability (math.PR)
subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: A priori dimension reduction is a widely adopted technique for reducing the computational complexity of stationary inverse problems. In this setting, the solution of an inverse problem is parameterized by a low-dimensional basis that is often obtained from the truncated Karhunen-Loeve expansion of the prior distribution. For high-dimensional inverse problems equipped with smoothing priors, this technique can lead to drastic reductions in parameter dimension and significant computational savings. In this paper, we extend the concept of a priori dimension reduction to non-stationary inverse problems, in which the goal is to sequentially infer the state of a dynamical system. Our approach proceeds in an offline-online fashion. We first identify a low-dimensional subspace in the state space before solving the inverse problem (the offline phase), using either the method of "snapshots" or regularized covariance estimation. Then this subspace is used to reduce the computational complexity of various filtering algorithms - including the Kalman filter, extended Kalman filter, and ensemble Kalman filter - within a novel subspace-constrained Bayesian prediction-and-update procedure (the online phase). We demonstrate the performance of our new dimension reduction approach on various numerical examples. In some test cases, our approach reduces the dimensionality of the original problem by orders of magnitude and yields up to two orders of magnitude in computational savings.
title: Ultrasound assessment of thyroid nodules – review of the ACR Thyroid Imaging, Reporting and Data System (TI-RADS)
Creators: name: Dixon, Andrew
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Thyroid / Parathyroids
subject: Ultrasound
subject: Biopsy
subject: Neoplasia

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: To inform the reader of the American College of Radiology's Thyroid Imaging, Reporting and Data System (ACR TI-RADS) for the ultrasound assessment of thyroid nodules. Via a series of clinical scenarios, this educational poster will explore the...
title: CTCA vs Coronary Catheter Angiography in the diagnosis of coronary artery sarcoidosis: A pictorial case report
Creators: name: Govindasamy, Jayamanee
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Diagnostic procedure
subject: MR
subject: CT-Angiography
subject: Catheter arteriography
subject: Arteries / Aorta
subject: Cardiac
subject: Education and training

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: Sarcoidosis is an inflammatory disease characterised by non-caseating granulomas which may include multisystem involvement. Approximately 20-30% of patients with sarcoidosis were demonstrated in an autopsy study to have cardiac involvement. 1...
Balanced presentations of the trivial group and four-dimensional geometry
Creators: name: Lishak, Boris
name: Nabutovsky, Alexander
Publisher: name: arXiv
Year: 2015
Subjects: subject: Metric Geometry (math.MG)
subject: FOS: Mathematics

description: We prove that 1) There exist infinitely many non-trivial codimension one "thick" knots in $\mathbb{R}^5$; 2) For each closed four-dimensional smooth manifold $M$ and for each sufficiently small positive $ε$ the set of isometry classes of Riemannian metrics with volume equal to $1$ and injectivity radius greater than $ε$ is disconnected; 3) For each closed four-dimensional $PL$-manifold $M$ and any $m$ there exist arbitrarily large values of $N$ such that some two triangulations of $M$ with $
title: Mechanical thrombectomy for acute stroke with large vessel occlusion: A single centre audit
Creators: name: Nelles, Ricky
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Interventional vascular
subject: Neuroradiology brain
subject: CNS
subject: Catheter arteriography
subject: Audit and standards
subject: Thrombolysis
subject: Recanalisation
subject: Embolism / Thrombosis
subject: Ischaemia / Infarction

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Background Ischaemic stroke is the second largest cause of mortality in Australia. The incidence of stroke in Australia in 2017 was 226 per 100,000 people and 80% of these are ischaemic events.(1,2) Rapid revascularisation has become the primary...
Exposure to Hydrogen Peroxide Induces Oxidation and Activation of AMP-activated Protein Kinase
Creators: name: Abraham, Edward
name: Lazarowski, Eduardo R.
name: Zmijewski, Jaroslaw W.
name: Friggeri, Arnaud
name: Bae, Hongbeom
name: Banerjee, Sami
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Although metabolic conditions associated with an increased AMP/ATP ratio are primary factors in the activation of 5′-adenosine monophosphate-activated protein kinase (AMPK), a number of recent studies have shown that increased intracellular levels of reactive oxygen species can stimulate AMPK activity, even without a decrease in cellular levels of ATP. We found that exposure of recombinant AMPKαβγ complex or HEK 293 cells to H2O2 was associated with increased kinase activity and also resulted in oxidative modification of AMPK, including S-glutathionylation of the AMPKα and AMPKβ subunits. In experiments using C-terminal truncation mutants of AMPKα (amino acids 1–312), we found that mutation of cysteine 299 to alanine diminished the ability of H2O2 to induce kinase activation, and mutation of cysteine 304 to alanine totally abrogated the enhancing effect of H2O2 on kinase activity. Similar to the results obtained with H2O2-treated HEK 293 cells, activation and S-glutathionylation of the AMPKα subunit were present in the lungs of acatalasemic mice or mice treated with the catalase inhibitor aminotriazole, conditions in which intracellular steady state levels of H2O2 are increased. These results demonstrate that physiologically relevant concentrations of H2O2 can activate AMPK through oxidative modification of the AMPKα subunit. The present findings also imply that AMPK activation, in addition to being a response to alterations in intracellular metabolic pathways, is directly influenced by cellular redox status.
(4008) William [Alexander] Clark
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Glucocorticoids Modulate MicroRNA Expression and Processing during Lymphocyte Apoptosis
Creators: name: Cidlowski, John A.
name: Smith, Lindsay K.
name: Shah, Ruchir R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Glucocorticoids modulate immune development and function through the induction of lymphocyte apoptosis via mechanisms requiring alterations in gene expression. Recently, short, noncoding, microRNAs have been identified as key regulators of lymphocyte function; however, it is unknown whether glucocorticoids regulate noncoding microRNAs and whether this regulation contributes to lymphocyte apoptosis. We now show by both microarray and deep sequencing analysis that microRNAs are substantially repressed during glucocorticoid-induced apoptosis of primary rat thymocytes. Mechanistic studies revealed that primary microRNA transcripts were not repressed, whereas the expression of the key microRNA processing enzymes: Dicer, Drosha, and DGCR8/Pasha, were significantly reduced at both the mRNA and protein levels during glucocorticoid-induced apoptosis. To delineate the role of Dicer depletion and microRNA repression in apoptosis, we silenced Dicer expression in two human leukemic cell lines and demonstrated that Dicer depletion significantly enhanced glucocorticoid-induced apoptosis in both model systems. Finally, in vitro and in vivo overexpression of the conserved miR-17–92 polycistron, which was repressed significantly by dexamethasone treatment in both our microarray and deep sequencing studies, blunted glucocorticoid-induced apoptosis. These studies provide evidence of altered post-transcriptional microRNA expression and the repression of the microRNA bioprocessing pathway during glucocorticoid-induced apoptosis of lymphocytes, suggesting a role for microRNA processors and specific microRNAs in cell life/death decisions.
Additional file 6 of Revascularization outcomes in diabetic patients presenting with acute coronary syndrome with non-ST elevation
Creators: name: Ram, Eilon
name: Fisman, Enrique Z.
name: Tenenbaum, Alexander
name: Iakobishvili, Zaza
name: Peled, Yael
name: Raanani, Ehud
name: Sternik, Leonid
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology
subject: Science Policy
subject: Hematology
subject: 60506 Virology

description: Additional file 6: Figure S5. Overall 10-year survival curves by revascularization strategy among subgroup of female patients. CABG, Coronary artery bypass graft; PCI, Percutaneous coronary intervention.
Brachyuran diversity along Mediterranean Egypt, with the addition of a new introduced species
Creators: name: MOUSSA, Ragia
name: KAPIRIS, Kostas
name: ZENETOS, Argyro
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2016

description: An annotated check list of brachyuran decapods along the Egyptian Mediterranean coast includes 62 species, 16 of which are introduced in the area. This work reports the presence of the Indo-Pacific xanthoid crab Halimede ochtodes (Herbst, 1783) in Egyptian Mediterranean waters. Although ship transfer in ballast waters is possible, Lessepsian migration (progressive unaided transfer via the Suez Canal) appears to be the most plausible vector of its introduction. Its potential impact on the Mediterranean shrimp aquaculture is discussed.
title: Bladder dose reduction with hydrogel spacer in high dose rate cervix brachytherapy – a dosimetric planning study
Creators: name: Ong, Wee Loon
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Genital / Reproductive system female
subject: MR
subject: Brachytherapy
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Giventhe proximity of bladder to cervix, dosimetric constraints on bladder (organ at risk, OAR), as defined by GEC-ESTRO guidelines e.g. D2cc<90Gy (Potter R et al 2006) can often limit the total dose and dosimetric coverage to the cervix (high risk...
ÉTUDE SUR LES CORALLINACÉES. L CARACTÈRES GÉNÉRAUX DE LA CYTOLOGIE
Creators: name: CABIOCH, Jacqueline
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1971

description: The present work is the first part of a study on the morphogenesis of the Corallinaceae and it deals with the cellular peculiarities proper to that family of Algae.
The main cell-components are described in the first chapter of the paper. After a brief review of our knowledge on the cell-wall calcification phenomenon, the description of some structural transformations, related to the vegetative stage of the Alga, is given. Some features of the vacuolar system are described and also the synthesis of floridean starch, which seems to take place, in some cases, in a peculiar cytoplasmie amylogenetic area (Pseudolithophyllum expansum). The occurrence of two kinds of siderophilic inclusions is shown.
In the second chapter, some important cytological phenomena, from the point of view of systematics and phytogeny, are presented. Those are the formation of lateral connexions between neighbouring cells of adjacent filaments and the production, sometimes complicated, of trichocytes and megacells. A comparison is drawn with similar phenomena, observed in other Florideae. The lateral connexions seem to result from the senescence of the tissues; they arise, after dissolution of a cell-wall area, either as direct secondary pit connexions, without any nuclear correlated activity, or through a cell fusion, which involves the fusion of the cytoplasms and even sometimes of the nuclei. The question whether these phenomena are or not parasexual is discussed. As regards the haircells and trichocytes, a comparative example, chosen out of the Corallinaceae, is that of Dumontia incrassata: the formation of haircells is the result of a series of cell différenciations and dedifferenciations. In the Corallinaceae, it is accompanied with cell-wall transformations. Two - or three - celled trichocytes originate in perithallial initial cells and keep included in a single calcified cell-wall. Their top cells take the form of celluloso-pectic hairs, without any cell division. A series of stages of increasing complexity is described. In the sim
Phoronida from the Eastern Mediterranean and Black Sea
Creators: name: EMIG, Christian C.
name: ÇINAR, Melih Ertan
name: ERGEN, Zeki
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2003

description: Faunistic analysis of benthic materials collected in various habitats at different depths in the eastern
 Mediterranean and the Black Sea revealed two phoronid species, Phoronis muelleri and P. psammophila, which were also
 known in many localities in the western Mediterranean. The Black Sea material comprised only Phoronis psammophila
 whereas the Aegean Sea and Levant Sea materials contained both P. psammophila and P. muelleri. The diagnosis and the
 ecological and reproductive features of these species as well as their associated polychaete fauna are provided. Our present
 knowledge of the biodiversity and geographic distribution of the three phoronid species occurring in the studied area, the
 third being P. australis, is developed including unpublished data.
The optical torque on small bi-isotropic particles
Creators: name: Nieto-Vesperinas, Manuel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Most previous theoretical studies on the optical torque exerted by light on dipolar particles are incomplete. Here we establish the equations for the time-averaged optical torque on dipolar bi-isotropic particles. Due to the interference of scattered fields, it has a term additional to that commonly employed in theory and experiments. Its consequences for conservation of energy, angular momentum, and effects like negative torques, are discussed.
title: Assessing prostate volume: should MRI be the new gold standard?
Creators: name: McKenzie, Jemima
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Genital / Reproductive system male
subject: MR
subject: Ultrasound
subject: Diagnostic procedure
subject: Multidisciplinary cancer care
subject: Patterns of Care

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Background There is minimal literature examining the role of MRIin assessment of prostate volume. Transrectal ultrasound (TRUS) remains the gold standard. Multi-parametric MRI is now routinely used in clinical practice, resulting in MRI determined...
TFD Extension of Open String Field Theory
Creators: name: Cantcheff, M. Botta
name: Santos, R. J. Scherer
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the application of the rules of Thermo Field Dynamics (TFD) to the covariant formulation of Open String Field Theory (OSFT). We extend the states space and fields according to the duplication rules of TFD and construct the corresponding classical action. The result is interpreted as a theory whose fields would encode the statistical information of open strings. The physical spectrum of the free theory is studied through the cohomology of the extended BRST charge, and, as a result, we get new fields in the spectrum emerging by virtue of the quantum entanglement and, noticeably, it presents degrees of freedom that could be identified as those of closed strings. We also show, however, that their appearing in the action is directly related to the choice of the inner product in the extended algebra, so that different sectors of fields could be eliminated from the theory by choosing that product conveniently. Finally, we study the extension of the three-vertex interaction and provide a simple prescription for it whose results at tree-level agree with those of the conventional theory.
description: 25 pages, no figures. File format, typos, Abstract and references modified. New subsection and concluding comments were added. To appear in Phys. Rev. D
title: Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia: A Rare Subtype of Premalignant Pulmonary Carcinoid
Creators: name: Watkinson, Kim
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Lung
subject: Anatomy
subject: Respiratory system
subject: CT-High Resolution
subject: CT
subject: Plain radiographic studies
subject: Education
subject: Biopsy
subject: Cancer
subject: Hyperplasia / Hypertrophy
subject: Pathology

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: To describe and illustrate the differences between different types of carcinoids, as diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) may represent a rare subtype of premalignant pulmonary carcinoid. In the poster we will...
Human Alveolar Type II Cells Secrete and Absorb Liquid in Response to Local Nucleotide Signaling
Creators: name: Okada, Seiko F.
name: Grubb, Barbara R.
name: Boucher, Richard C.
name: Ribeiro, Carla M.P.
name: Randell, Scott H.
name: Rogers, Troy D.
name: Bove, Peter F.
name: O'Neal, Wanda K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: A balance sheet describing the integrated homeostasis of secretion, absorption, and surface movement of liquids on pulmonary surfaces has remained elusive. It remains unclear whether the alveolus exhibits an intra-alveolar ion/liquid transport physiology or whether it secretes ions/liquid that may communicate with airway surfaces. Studies employing isolated human alveolar type II (AT2) cells were utilized to investigate this question. Human AT2 cells exhibited both epithelial Na+ channel-mediated Na+ absorption and cystic fibrosis transmembrane conductance regulator-mediated Cl− secretion, both significantly regulated by extracellular nucleotides. In addition, we observed in normal AT2 cells an absence of cystic fibrosis transmembrane conductance regulator regulation of epithelial Na+ channel activity and an absence of expression/activity of reported calcium-activated chloride channels (TMEM16A, Bestrophin-1, ClC2, and SLC26A9), both features strikingly different from normal airway epithelial cells. Measurements of alveolar surface liquid volume revealed that normal AT2 cells: 1) achieved an extracellular nucleotide concentration-dependent steady state alveolar surface liquid height of ∼4 μm in vitro; 2) absorbed liquid when the lumen was flooded; and 3) secreted liquid when treated with UTP or forskolin or subjected to cyclic compressive stresses mimicking tidal breathing. Collectively, our studies suggest that human AT2 cells in vitro have the capacity to absorb or secrete liquid in response to local alveolar conditions.
title: Development and Validation of Knowledge Based Planning for SBRT Lung Radiotherapy
Creators: name: Podreka, Alexander
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Oncology
subject: Lung
subject: Computer applications
subject: CT
subject: Radiation therapy / Oncology
subject: Stereotactic radiotherapy
subject: Dosimetry
subject: Cancer
subject: Radiotherapy techniques
subject: Dosimetric comparison

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: The Northern Sydney Cancer Center (NSCC) has been treating lung stereotactic body radiation therapy (SBRT) since 2010. Local experience and externally published studies 1 have observed a variation in plan quality for this type of complex treatment...
(4009) Janet Hannah
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 7 of Revascularization outcomes in diabetic patients presenting with acute coronary syndrome with non-ST elevation
Creators: name: Ram, Eilon
name: Fisman, Enrique Z.
name: Tenenbaum, Alexander
name: Iakobishvili, Zaza
name: Peled, Yael
name: Raanani, Ehud
name: Sternik, Leonid
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology
subject: Science Policy
subject: Hematology
subject: 60506 Virology

description: Additional file 7: Figure S6. Overall 10-year survival curves by revascularization strategy of patients with non-ST elevation myocardial infarction *. *p-value is for the landmark analysis: 0–2 years; from 2 years and thereafter. CABG, Coronary artery bypass grafting; PCI, Percutaneous coronary intervention.
The role of the g9/2 orbital in the development of collectivity in the A = 60 region: The case of 61Co
Creators: name: Ayangeakaa, A. D.
name: Zhu, S.
name: Janssens, R. V. F.
name: Carpenter, M. P.
name: Albers, M.
name: Alcorta, M.
name: Baugher, T.
name: Bertone, P. F.
name: Chiara, C. J.
name: Chowdhury, P.
name: David, H. M.
name: Deacon, A. N.
name: DiGiovine, B.
name: Gade, A.
name: Hoffman, C. R.
name: Kondev, F. G.
name: Lauritsen, T.
name: Lister, C. J.
name: McCutchan, E. A.
name: Moerland, D. S.
name: Nair, C.
name: Rogers, A. M.
name: Seweryniak, D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: An extensive study of the level structure of 61Co has been performed following the complex 26Mg(48Ca, 2a4npg)61Co reaction at beam energies of 275, 290 and 320 MeV using Gammasphere and the Fragment Mass Analyzer (FMA). The low-spin structure is discussed within the framework of shell-model calculations using the GXPF1A effective interaction. Two quasi-rotational bands consisting of stretched-E2 transitions have been established up to spins I = 41/2 and (43/2), and excitation energies of 17 and 20 MeV, respectively. These are interpreted as signature partners built on a neutron ν(g9/2)2 configuration coupled to a proton πp3/2 state, based on Cranked Shell Model (CSM) calculations and comparisons with observations in neighboring nuclei. In addition, four I = 1 bands were populated to high spin, with the yrast dipole band interpreted as a possible candidate for the shears mechanism, a process seldom observed thus far in this mass region.
Identification of Protein-Protein and Protein-Ribosome Interacting Regions of the C-terminal Tail of Human Mitochondrial Inner Membrane Protein Oxa1L
Creators: name: Fecko, Christopher J.
name: Spremulli, Linda L.
name: Haque, Md Emdadul
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The mammalian mitochondrial inner membrane protein Oxa1L is involved in the insertion of a number of mitochondrial translation products into the inner membrane. During this process, the C-terminal tail of Oxa1L (Oxa1L-CTT) binds mitochondrial ribosomes and is believed to coordinate the synthesis and membrane insertion of the nascent chains into the membrane. The C-terminal tail of Oxa1L does not contain any Cys residues. Four variants of this protein with a specifically placed Cys residue at position 4, 39, 67, or 94 of Oxa1L-CTT have been prepared. These Cys residues have been derivatized with a fluorescent probe, tetramethylrhodamine-5-maleimide, for biophysical studies. Oxa1L-CTT forms oligomers cooperatively with a binding constant in the submicromolar range. Fluorescence anisotropy and fluorescence lifetime measurements indicate that contacts near a long helix close to position 39 of Oxa1L-CTT occur during oligomer formation. Fluorescence correlation spectroscopy measurements demonstrate that all of the Oxa1L-CTT derivatives bind to mammalian mitochondrial ribosomes. Steady-state fluorescence quenching and fluorescence lifetime data indicate that there are extensive contacts between Oxa1L-CTT and the ribosome-encompassing regions around positions 39, 67, and 94. The results of this study suggest that Oxa1L-CTT undergoes conformational changes and induced oligomer formation when it binds to the ribosome.
Efectos tóxicos en ecosistemas derivados de contaminación ambiental por fármacos. Revisión de alcance
Creators: name: Romero, Daniela Katherine Sedano
name: Bayona, David Andrés Combariza
name: Salazar, Catalina Montenegro
name: Ramírez, Juan Camilo Pinzón
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Pharmacology, Toxicology and Environmental Health
subject: Medicine and Health Sciences
subject: Other Pharmacology, Toxicology and Environmental Health
subject: Veterinary Toxicology and Pharmacology
subject: Veterinary Medicine
subject: Life Sciences
subject: Ecopharmacovigilance
subject: Pharmaceutical preparations
subject: Pharmaceutical pollution
subject: Toxic effects

description: Protocolo de la revisión de alcance sobre los efectos tóxicos en ecosistemas acuáticos asociados a la exposición ambiental a fármacos y sus metabolitos, tanto de uso humano como veterinario
Identification of Ror2 as a Hypoxia-inducible Factor Target in von Hippel-Lindau-associated Renal Cell Carcinoma
Creators: name: Rathmell, W. Kimryn
name: Wright, Tricia M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Ror2 is an orphan receptor tyrosine kinase with expression normally restricted to early stages of development. However, emerging evidence has placed aberrantly expressed Ror2, leading to an invasive phenotype, in several cancers including renal cell carcinoma (RCC). Although Ror2 is currently identified as up-regulated in an assortment of cancers, neither the regulatory role or mechanism of action have been delineated. We sought to place Ror2 in the most commonly mutated pathway of RCC, the loss of the tumor suppressor von Hippel-Lindau (VHL), which causes hypoxia-inducible factor (HIF)-1α and -2α stabilization and the transcriptional activation of a broad repertoire of response genes. We found that Ror2 was indeed associated with the pVHL loss in RCC as well as with VHL somatic mutations tightly coordinated with the induction of RCC. Additionally, knockdown and rescue analysis of HIF expression suggests that Ror2 is dependent on pathologic stabilization of either HIF-1α or HIF-2α. Subsequent evaluation of the ROR2 promoter suggests that HIF-2α and its dimerization partner, aryl hydrocarbon nuclear transferase localize to the ROR2 promoter via a cryptic transcriptional element. This data substantiates a unique regulation pattern for Ror2 in the VHL-HIF axis that has the potential to be applied to other cancer etiologies.
Resurrection of Galathowenia australis (Polychaeta, Oweniidae) based upon type material
Creators: name: PARAPAR, Julio
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2003

description: From the examination of the syntypes, Psammocollus australis (Polychaeta: Oweniidae), type locality Saint Paul Island
 (subantarctic region of the Indian Ocean), is considered valid and resurrected. The species is redescribed and a lectotype and
 paralectotypes are designated. The genus Psammocollus is removed from synonymy with Myriochele and is considered to be a senior
 subjective synonym of the genus Galathowenia. The species Galathowenia australis, characterized by the presence of notopodial short
 capillary chaetae, is compared with other eleven species of Galathowenia.
In Silico Docking and Electrophysiological Characterization of Lacosamide Binding Sites on Collapsin Response Mediator Protein-2 Identifies a Pocket Important in Modulating Sodium Channel Slow Inactivation
Creators: name: Wang, Yuying
name: Wilson, Sarah M.
name: Hale, Rachel
name: Wang, Bo
name: Cummins, Theodore R.
name: Brittain, Joel M.
name: Park, Ki Duk
name: Meroueh, Samy O.
name: Khanna, Rajesh
name: Jarecki, Brian W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The anti-epileptic drug (R)-lacosamide ((2R)-2-(acetylamino)-N-benzyl-3-methoxypropanamide (LCM)) modulates voltage-gated sodium channels (VGSCs) by preferentially interacting with slow inactivated sodium channels, but the observation that LCM binds to collapsin response mediator protein 2 (CRMP-2) suggests additional mechanisms of action for LCM. We postulated that CRMP-2 levels affects the actions of LCM on VGSCs. CRMP-2 labeling by LCM analogs was competitively displaced by excess LCM in rat brain lysates. Manipulation of CRMP-2 levels in the neuronal model system CAD cells affected slow inactivation of VGSCs without any effects on other voltage-dependent properties. In silico docking was performed to identify putative binding sites in CRMP-2 that may modulate the effects of LCM on VGSCs. These studies identified five cavities in CRMP-2 that can accommodate LCM. CRMP-2 alanine mutants of key residues within these cavities were functionally similar to wild-type CRMP-2 as assessed by similar levels of enhancement in dendritic complexity of cortical neurons. Next, we examined the effects of expression of wild-type and mutant CRMP-2 constructs on voltage-sensitive properties of VGSCs in CAD cells: 1) steady-state voltage-dependent activation and fast-inactivation properties were not affected by LCM, 2) CRMP-2 single alanine mutants reduced the LCM-mediated effects on the ability of endogenous Na+ channels to transition to a slow inactivated state, and 3) a quintuplicate CRMP-2 alanine mutant further decreased this slow inactivated fraction. Collectively, these results identify key CRMP-2 residues that can coordinate LCM binding thus making it more effective on its primary clinical target.
Two-dimensional electrophoresis analysis of proteins from epitokous forms of the polychaete Perinereis cultrifera from the English Channel and the Mediterranean Sea
Creators: name: ROUABAH, Abdelkader
name: SCAPS, Patrick
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2003

description: We compared the general protein patterns of different populations of the epitokous form of the polychaete
 Perinereis cultrifera from the English Channel (Normandy and the north coast of Brittany) and the Mediterranean Sea
 (Algerian coast near the Tunisian boarder) using high resolution two-dimensional gel electrophoresis (2-DGE). Data sets
 were converted to similarity coefficients using the Dice coefficient, based on more than 150 protein spots. UPGMA
 dendrogram reveals a clear distinction between the three populations, individuals from the same population clustering
 together. The genetic distances between populations from the English Channel and the Mediterranean are large compared to
 those within populations. As a consequence, our results indicate a restricted gene flow between our sampled populations. In
 addition, the general protein pattern of individuals from the Mediterranean contains 5 exclusive spots whereas no specific
 spots were detected between the two populations of the English Channel which share one exclusive spot by comparison to
 the mediterranean form.
Induction and Evasion of Innate Antiviral Responses by Hepatitis C Virus
Creators: name: Lemon, Stanley M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Persistent hepatitis C virus infection is associated with progressive hepatic fibrosis and liver cancer. Acute infection evokes several distinct innate immune responses, but these are partially or completely countered by the virus. Hepatitis C virus proteins serve dual functions in replication and immune evasion, acting to disrupt cellular signaling pathways leading to interferon synthesis, subvert Jak-STAT signaling to limit expression of interferon-stimulated genes, and block antiviral activities of interferon-stimulated genes. The net effect is a multilayered evasion of innate immunity, which negatively influences the subsequent development of antigen-specific adaptive immunity, thereby contributing to virus persistence and resistance to therapy.
Age, growth and mortality of the Red Sea invasive blotchfin dragonet, Callionymus filamentosus Valenciennes, 1837 from the Northeastern Mediterranean, Turkey
Creators: name: ERGUDEN, Deniz
name: ALAGOZ ERGUDEN, Sibel
name: OZDEMIR, Okan
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2016

description: The blotchfin dragonet Callionymus filamentosus Valenciennes, 1837 is a Red Sea immigrant that was first recorded from the Turkish coast in 1994. To date, there has been little or no information on the biological parameters of C. filamentosus in the Mediterranean Sea. The present study aims to first determine the age and growth parameters of blotchfin dragonet C. filamentosus established in the Iskenderun Bay, northeastern Mediterranean. A total of 341 C. filamentosus were caught by commercial vessels from Iskenderun Bay (northeastern Mediterraenan, Turkey) between October 2012 and September 2013. The maximum age was found to be 5+ years for both sexes combined, the 1+ age group comprised of 56.0% of samples. The total length distribution of C. filamentosus ranged from 7.2-17.5 cm, and the weight distribution from 3.24-41.89 g. Growth equations for females were calculated as W=0.0131xL2.820 (R2 = 0.985) for males as W = 0.0155xL2.757 (R2 = 0.989) and for all individuals as W= 0.0142xL2.792 (R2 = 0.987). Von Bertalonffy growth parameters were L∞ = 21.22 cm, K= 0.235 year-1, t0 = -2.101 years for females, L∞ = 22.24 cm, K = 0.215 year-1, t0 = -2.182 years for males, and as L∞ = 21.93 cm, K = 0.213 year-1, t0 = -2.150 years for combined sexes. Overall total mortality was estimated as 0.62 year-1, natural mortality was 0.41 year-1 and fishing mortality was 0.21 year-1.
(4010) [adwen] Howatson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.