cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Diffusion de la vapeur et condensation
Creators: name: Latta, J. K.
name: Beach, R. K.
Publisher: name: Conseil national de recherches du Canada. Division des recherches en construction
Year: 1967
Subjects: subject: Air and vapour barriers
valueUri: urn:ircsubjects:IRC0310
subject: Pare-vapeur et pare-air
valueUri: urn:ircsubjects:IRC0310
subject: vapour flow
subject: écoulement de la vapeur
subject: vapour pressure
subject: pression de vapeur
subject: water vapour
subject: vapeur d' eau
subject: surface condensation
subject: condensation superficielle
subject: vapour barriers
subject: pare vapeur
subject: external walls
subject: mur de façade

description: Le présent Digeste décrit une méthode à l'aide de laquelle l'architecte peut choisir la nature et l'emplacement des matériaux de telle facon que l'accumulation préjudiciable de l'humidité provenant de la diffusion de la vapeur puisse être évitée.
Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques
Creators: name: Festag, Marvin M.
name: Swanson, Tonya
name: Klug, Alex
name: Jacob, Thomas
name: Norris, Reed
name: Wu, Helen L.
name: Northrup, Mina
name: Burwitz, Benjamin J.
name: Hammond, Katherine B.
name: Asokan, Aravind
name: Legasse, Alfred W.
name: Esser, Knud
name: Wettengel, Jochen M.
name: Protzer, Ulrike
name: Ko, Chunkyu
name: Vu, Tania Q.
name: Moller-Tank, Sven
name: Reed, Jason S.
name: Sutton, William F.
name: Abdulhaqq, Shaheed
name: Haigwood, Nancy L.
name: Bimber, Benjamin N.
name: Sacha, Jonah B.
name: Webb, Gabriela
name: Park, Byung
name: Ringelhan, Marc
name: Greene, Justin M.
name: Mück-Häusl, Martin A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Hepatitis B virus (HBV) is a major global health concern, and the development of curative therapeutics is urgently needed. Such efforts are impeded by the lack of a physiologically relevant, pre-clinical animal model of HBV infection. Here, we report that expression of the HBV entry receptor, human sodium-taurocholate cotransporting polypeptide (hNTCP), on macaque primary hepatocytes facilitates HBV infection in vitro, where all replicative intermediates including covalently closed circular DNA (cccDNA) are present. Furthermore, viral vector-mediated expression of hNTCP on hepatocytes in vivo renders rhesus macaques permissive to HBV infection. These in vivo macaque HBV infections are characterized by longitudinal HBV DNA in serum, and detection of HBV DNA, RNA, and HBV core antigen (HBcAg) in hepatocytes. Together, these results show that expressing hNTCP on macaque hepatocytes renders them susceptible to HBV infection, thereby establishing a physiologically relevant model of HBV infection to study immune clearance and test therapeutic and curative approaches.
Density count of Leucadendron pubescens and Paranomus bracteolaris at site 3219AC/12
Creators: name: Jonkershoek Forestry Research Center
Publisher: name: South African Environmental Observation Network
Year: 2022
Subjects: Jonkershoek Forestry Research Centre
datasheet
density counts
Leucadendron pubescens
Paranomus bracteolaris

description: This is a scanned copy of a datasheet noting the density count of Leucadendron pubescens and Paranomus bracteolaris at site 3219AC/12. The Jonkershoek Forestry Research Center (part of the former South African Forestry Research Institute) was established in 1935 at Jonkershoek, near Stellenbosch, under the directorship of Dr C. L. Wicht. The initial aim was to determine how forestry activities in state plantations would affect climate, water conservation and erosion, and was later expanded to include studies of fynbos ecology, fire and alien species.    Studies from the 1930s to the early 1990s saw the accumulation of a large amount of data dealing with fire experiments, detailed vegetation plot surveys, rare plant surveys and ecological studies, hydrological studies and the development of management plans for catchments around the Western Cape.   SAEON now houses the archive of data collected by the Jonkershoek Forestry Research Center, which was originally held by the Council for Scientific and Industrial Research (CSIR).
title: Instructors as Orchestrators: A Qualitative Case Study that Explores the role of Instructors in an Adaptive Learning Classroom Environment
Creators: name: Rafhi, Ziad
Publisher: name: University of Liverpool Repository
Year: 2021

description: This qualitative case study highlights the vital role of the instructor and the importance of learning analytics (LA) in an adaptive learning (AL) classroom environment. Existing research does not consistently support a particular outcome for the use of the AL platform, ALEKS, as an instructional approach. An examination of the AL landscape has been characterized by inconsistent and inconclusive results. The persistent emphasis on students’ attitudes and performance in relation to ALEKS, along with the comparative approach to traditionally taught classes, have prevented us from understanding the complex and multifaceted ALEKS classroom environment. This study is novel because it distinguishes itself from previous research by providing the AL landscape with a supplementary lens – that of the instructors. By exploring how the instructors in this study used the LA from ALEKS to enrich the students’ learning experiences, we intended to gain a renewed understanding and a reconceptualization of the instructor’s role from a parameter that can be overlooked to an orchestrator whose presence is vital. This study draws on Laurillard’s Conversational Framework (CF) as a theoretical foundation, which promotes an education-driven approach where technology serves pedagogy, not the other way around. This allows for an evaluation that challenges ALEKS to deliver on what education requires of it, and makes visible the vital role that educators play in the classroom. In sharp contrast with the quantitative orientation that has dominated previous research studies, this study espouses a qualitative stance to inquiry using open-ended research questions. Therefore, this dissertation employs semi-structured interviews, classroom observations, and documentary evidence as data collection methods to paint a vibrant image of the case study under investigation. The findings demonstrate the multi-layered and intricate nature of an AL classroom environment. Evidence suggests that an AL approach to instruction depends on the active and engaged presence of instructors. Using the LA from the AL platform to cater to the individual needs of every student became an integral part of the instructor’s role in the ALEKS classes studied. Further evidence indicates that the LA in ALEKS contributes towards a positive classroom dynamic and enhanced learner-instructor interaction. The CF adds another dimension to the findings and leads to an improved articulation of how the different aspects of learning are enacted in an AL environment. The study concludes with an array of recommendations for implementers and decision-makers with regard to leading a successful AL experience.
title: Déformation des matériaux de construction par suite des variations thermiques et hygrométriques
Creators: name: Baker, M. C.
Publisher: name: Conseil national de recherches du Canada. Division des recherches en construction
Year: 1967
Subjects: subject: Hygrothermal properties
valueUri: urn:ircsubjects:IRC0760
subject: Propriétés hygrothermiques
valueUri: urn:ircsubjects:IRC0760
subject: crackings (breaking)
subject: fissuration
subject: spallings
subject: épaufrure
subject: glasses (materials)
subject: verre (matériau)
subject: joints (junctions)
subject: joint (liaison)
subject: thermal stresses
subject: contrainte thermique
subject: elastic deformation
subject: déformation élastique
subject: nonelastic deformation
subject: déformation non élastique
subject: swelling
subject: gonflement (altération)
subject: shrinkage
subject: retrait (altération)
subject: dimensional stability
subject: stabilité dimensionnelle

description: A peine terminés, un grand nombre de bâtiments sont déjà enlaidis par la fissuration du verre et des matériaux de finition, l'écaillage des revêtements, la désagrégation des joints de mastic et parfois par la dislocation d'un assemblage. Les mécanismes auxquelles on peut attribuer ces dégâts sont habituellement liés aux déformations des matériaux causées par les variations de leur température et de leur teneur en humidité ou par une réaction chimique. On tente de montrer dans le présent digeste la nécessité de mieux tenir compte, lors de la conception des bâtiments, des déformations et des contraintes qu'engendrent les variations de la température et de la teneur en humidité des matériaux assujettis.
Neural NILM: Deep Neural Networks Applied to Energy Disaggregation
Creators: name: Kelly, Jack
name: Knottenbelt, William
Publisher: name: arXiv
Year: 2015
Subjects: subject: Neural and Evolutionary Computing (cs.NE)
subject: FOS: Computer and information sciences
subject: I.2.6; I.5.2

description: Energy disaggregation estimates appliance-by-appliance electricity consumption from a single meter that measures the whole home's electricity demand. Recently, deep neural networks have driven remarkable improvements in classification performance in neighbouring machine learning fields such as image classification and automatic speech recognition. In this paper, we adapt three deep neural network architectures to energy disaggregation: 1) a form of recurrent neural network called `long short-term memory' (LSTM); 2) denoising autoencoders; and 3) a network which regresses the start time, end time and average power demand of each appliance activation. We use seven metrics to test the performance of these algorithms on real aggregate power data from five appliances. Tests are performed against a house not seen during training and against houses seen during training. We find that all three neural nets achieve better F1 scores (averaged over all five appliances) than either combinatorial optimisation or factorial hidden Markov models and that our neural net algorithms generalise well to an unseen house.
description: To appear in ACM BuildSys'15, November 4--5, 2015, Seoul
Soil moisture in Hottentots Holland, Jakkalsrivier Catchment, site 3419AA/1/M/8
Creators: name: Jonkershoek Forestry Research Center
Publisher: name: South African Environmental Observation Network
Year: 2022
Subjects: Jonkershoek Forestry Research Centre
Hottentots Holland
Jakkalsrivier Catchment
Soil moisture

description: This is a scanned copy of a document on the soil moisture in Hottentots Holland, Jakkalsrivier Catchment, site 3419AA/1/M/8. The Jonkershoek Forestry Research Center (part of the former South African Forestry Research Institute) was established in 1935 at Jonkershoek, near Stellenbosch, under the directorship of Dr C. L. Wicht. The initial aim was to determine how forestry activities in state plantations would affect climate, water conservation and erosion, and was later expanded to include studies of fynbos ecology, fire and alien species. Studies from the 1930s to the early 1990s saw the accumulation of a large amount of data dealing with fire experiments, detailed vegetation plot surveys, rare plant surveys and ecological studies, hydrological studies and the development of management plans for catchments around the Western Cape.  SAEON now houses the archive of data collected by the Jonkershoek Forestry Research Center, which was originally held by the Council for Scientific and Industrial Research (CSIR).
title: Use of sealants
Creators: name: Garden, G. K.
Publisher: name: National Research Council of Canada. Division of Building Research
Year: 1967
Subjects: subject: Buildings
valueUri: urn:ircsubjects:IRC0721
subject: Bâtiments
valueUri: urn:ircsubjects:IRC0721
subject: elastomeric sealants
subject: mastic à base d'elastomère
subject: waterproof joints
subject: joint d'assemblage étanche

description: Through discussion of the effects of dimension and shape of the sealant bead cross section, joint design principles and the factors influencing sealant durability, simple basic rules for the use of sealants are developed.
Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor
Creators: name: Huang, Julianne
name: Little, Michael S.
name: Tilley, Stephen L.
name: Alexis, Neil E.
name: Redinbo, Matthew R.
name: Walton, William G.
name: Moore, Patrick J.
name: Fellner, Robert C.
name: Wu, Tongde
name: Tarran, Robert
name: Peter Di,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Asthma is a chronic airway disease characterized by inflammation, mucus hypersecretion and abnormal airway smooth muscle (ASM) contraction. Bacterial permeability family member A1, BPIFA1, is a secreted innate defence protein. Here we show that BPIFA1 levels are reduced in sputum samples from asthmatic patients and that BPIFA1 is secreted basolaterally from healthy, but not asthmatic human bronchial epithelial cultures (HBECs), where it suppresses ASM contractility by binding to and inhibiting the Ca2+ influx channel Orai1. We have localized this effect to a specific, C-terminal α-helical region of BPIFA1. Furthermore, tracheas from Bpifa1−/− mice are hypercontractile, and this phenotype is reversed by the addition of recombinant BPIFA1. Our data suggest that BPIFA1 deficiency in asthmatic airways promotes Orai1 hyperactivity, increased ASM contraction and airway hyperresponsiveness. Strategies that target Orai1 or the BPIFA1 deficiency in asthma may lead to novel therapies to treat this disease.
Integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions
Creators: name: Sicherer,
name: Cohain,
name: Burks,
name: Sampson,
name: Bunyavanich,
name: Wood,
name: Schadt,
name: Chun,
name: Griffin,
name: Hacyznska,
name: Henning,
name: Dawson,
name: Grishin,
name: Watson,
name: Leung,
name: Sharp,
name: Jones,
name: Shah,
name: Beckmann,
name: Hoffman,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Mechanisms driving acute food allergic reactions have not been fully characterized. We profile the dynamic transcriptome of acute peanut allergic reactions using serial peripheral blood samples obtained from 19 children before, during, and after randomized, double-blind, placebo-controlled oral challenges to peanut. We identify genes with changes in expression triggered by peanut, but not placebo, during acute peanut allergic reactions. Network analysis reveals that these genes comprise coexpression networks for acute-phase response and pro-inflammatory processes. Key driver analysis identifies six genes (LTB4R, PADI4, IL1R2, PPP1R3D, KLHL2, and ECHDC3) predicted to causally modulate the state of coregulated networks in response to peanut. Leukocyte deconvolution analysis identifies changes in neutrophil, naive CD4+ T cell, and macrophage populations during peanut challenge. Analyses in 21 additional peanut allergic subjects replicate major findings. These results highlight key genes, biological processes, and cell types that can be targeted for mechanistic study and therapeutic targeting of peanut allergy.
title: MANAGED AQUIFER RECHARGE (MAR) AR AS A TOOL TO MITIGATE AQUIFER OVEREXPLOITATION: INSIGHTS FROM LOS ARENALES AQUIFER (SPAIN).
Creators: name:  Casas ,  Jose David Henao
name:  Escalante ,  Enrique Fernández
name:  Ayuga ,  Francisco
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: Irrigation agriculture in Los Arenales aquifer has resulted in staggering groundwater level declines in the last quarter of the XX century. The objective of this study is to assess the contribution of MAR to reverse such a problematic situation. To this end, we compare two neighbouring and analogous groundwater bodies within this aquifer, namely Los Arenales (LA) and Medina del Campo (MC). The primary difference between them is the presence of three large-scale MAR sites in LA. We employ the Mann-Kendall test and Theil-Sen estimator for slope analysis and an empirical approach to assess field significance. Additionally, we compute the average groundwater levels and explore agricultural and climatological information to complement the statistical analysis. The slope analysis reflects a dramatic drop in groundwater levels in LA and MC during 1985-2001 (~100% of trends are negative) with slope strengths in the order of -1.5 m/year. The subsequent analysis periods (2002-2011 and 2012-2020) show a substantial improvement of groundwater availability in LA (~75% of the trends are positive) and marginally in MC (~25% of the trends are positive). No field significance was detected in the area. The analysis of average groundwater levels against climatological and agricultural information depicts the socioeconomic similarities between both groundwater bodies and the pronounced recovery in LA (~10% higher than the lowest average level) when compared to MC (~4%). This study demonstrates that MAR very likely accounts for the difference in groundwater storage recovery between LA and MC and the suitability of this technique to counteract aquifer overexploitation.
Non-Markovian continuous-time quantum walks on lattices with dynamical noise
Creators: name: Benedetti, Claudia
name: Buscemi, Fabrizio
name: Bordone, Paolo
name: Paris, Matteo G. A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We address the dynamics of continuous-time quantum walks on one-dimensional disordered lattices inducing dynamical noise in the system. Noise is described as time-dependent fluctuations of the tunneling amplitudes between adjacent sites, and attention is focused on non-Gaussian telegraph noise, going beyond the usual assumption of fast Gaussian noise. We observe the emergence of two different dynamical behaviors for the walker, corresponding to two opposite noise regimes: slow noise (i.e. strong coupling with the environment) confines the walker into few lattice nodes, while fast noise (weak coupling) induces a transition between quantum and classical diffusion over the lattice. A phase transition between the two dynamical regimes may be observed by tuning the ratio between the autocorrelation time of the noise and the coupling between the walker and the external environment generating the noise. We also address the non-Markovianity of the quantum map by assessing its memory effects, as well as evaluating the information backflow to the system. Our results suggest that the non-Markovian character of the evolution is linked to the dynamical behavior in the slow noise regime, and that fast noise induces a Markovian dynamics for the walker.
description: 10 pages, 8 figures
Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2
Creators: name: Akbay, Esra A.
name: Herter-Sprie, Grit S.
name: Wang, Xiaoen
name: Wong, Kwok-Kin
name: Kim, Carla F.
name: Rustgi, Anil K.
name: Saur, DIeter
name: Kwiatkowski, David J.
name: Marsh, Bryan P.
name: Sholl, Lynette M.
name: Bardeesy, Nabeel
name: Dranoff, Glenn
name: Garcia-De-Alba, Carolina
name: Palakurthi, Sangeetha
name: Koyama, Shohei
name: Hammerman, Peter S.
name: Paschini, Margherita
name: Chen, Ting
name: Brainson, Christine Fillmore
name: Watanabe, Hideo
name: Gupta, Manav
name: Zhang, Haikuo
name: Chen, Zhao
name: Ji, Hongbin
name: Lu, Gang
name: Zhang, Xin
name: Tuminello, Stephanie J.
name: Li, Shuai
name: Redig, Amanda J.
name: Sharpless, Norman E.
name: Xu, Chunxiao
name: DIehl, J Alan
name: Bass, Adam J.
name: Zheng, Mei
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Adenosquamous lung tumours, which are extremely poor prognosis, may result from cellular plasticity. Here, we demonstrate lineage switching of KRAS+ lung adenocarcinomas (ADC) to squamous cell carcinoma (SCC) through deletion of Lkb1 (Stk11) in autochthonous and transplant models. Chromatin analysis reveals loss of H3K27me3 and gain of H3K27ac and H3K4me3 at squamous lineage genes, including Sox2, ΔNp63 and Ngfr. SCC lesions have higher levels of the H3K27 methyltransferase EZH2 than the ADC lesions, but there is a clear lack of the essential Polycomb Repressive Complex 2 (PRC2) subunit EED in the SCC lesions. The pattern of high EZH2, but low H3K27me3 mark, is also prevalent in human lung SCC and SCC regions within ADSCC tumours. Using FACS-isolated populations, we demonstrate that bronchioalveolar stem cells and club cells are the likely cells-of-origin for SCC transitioned tumours. These findings shed light on the epigenetics and cellular origins of lineage-specific lung tumours.
The Department of Agriculture and the Missouri River Basin
Creators: name: United States Department Of Agriculture
name: United States Department Of Agriculture
Publisher: name: Unknown
Year: 1946
Subjects: Agricultural and Food Policy
Community/Rural/Urban Development
Crop Production/Industries
Labor and Human Capital
Land Economics/Use
Livestock Production/Industries
Resource /Energy Economics and Policy

description: Excerpt from the report: This document has been prepared for the use of the Missouri Basin Inter-Agency Committee. It is primarily a summary of the interests and activities of Department programs affecting resource use and development in the Missouri River Basin. The document includes also a statement of what appear to be the more significant agricultural objectives and problems that need to be reached or solved as part of the comprehensive development of the Basin, not only in relation to the estimated 50,000 farms to be directly reached by the projected irrigation developments, but also in relation to the many millions of acres and half-million other farms and ranches in the Basin which these developments will reach less directly, some only remotely. It is hoped that the following information, although general in nature, will be helpful to the Committee in its important assignment of facilitating the coordinated development of the Basin.
Scrophularia chlorantha Kotschy & Boiss.
Creators: name: Uzunhisarcikli, M. Erkan
name: Güner, Ebru Doğan
name: Ekici, Murat
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Lamiales
Scrophulariaceae
Scrophularia
Scrophularia chlorantha

description: 18. Scrophularia chlorantha Kotschy & Boiss. in Boiss., Fl. Orient. 4: 399 (1879)
 Type: — [TURKEY. B 8 Muş] in arenosis ad fontes pagi Goschkar prov. Musch Armeniae Turcicae, 1525 m, [19 August 1859,] Kotschy 346 (holotype G, isotype K!).
 Specimens seen: — TURKEY. Erzurum: Palandöken Mountain, streamsides, 2100 m, 20 June 2014, M. E.Uzunhisarcıklı 2574 (GAZI); ibid., 2200 m, 20 July 2014, M. E. Uzunhisarcıklı 2624 (GAZI).
 Flowering time:— June–August.
 Habitat:— Streamsides. 1525‒2200 m elevation.
 Distribution:— Irano-Turanian element.
description: Published as part of Uzunhisarcikli, M. Erkan, Güner, Ebru Doğan & Ekici, Murat, 2018, Synopsis of the genus Scrophularia (Scrophulariaceae) in Turkey, pp. 151-187 in Phytotaxa 333 (2) on page 164, DOI: 10.11646/phytotaxa.333.2.1, http://zenodo.org/record/13721306
Supplementary documentation for SAEON's field instrument data collected at the Cathedral Peak Weir 03 ISCO station
Creators: name: South African Environmental Observation Network (SAEON) Grasslands-Forests-Wetlands Node
Publisher: name: South African Environmental Observation Network
Year: 2022
Subjects: SAEON field instruments
Standard Operating Procedures
Calibration
Cathedral Peak
Hydrological
ISCO Sampler
Water samples

description: This package contains supporting information for the hydrological data collected at Cathedral Peak's Weir 03 ISCO station, as part of the South African Environmental Observation Network's monitoring projects.
Anais do 2º Colóquio do Centro e Núcleos de Pesquisa da UNIESP S.A.
Creators: name: UNIESP.S.A.
Publisher: name: Zenodo
Year: 2022
Subjects: Centro de ensino
Extensão e publicações
. Pesquisa

description: Estes Anais reúnem algumas das produções acadêmicas e das reflexões críticas originadas do 2º Colóquio do Centro e Núcleos de Pesquisa da UNIESP S.A, que teve lugar em São Paulo no dia 17 de outubro de 2022, a partir das 19h. e cujo tema geral gravitou em torno de questões importantes sobre Saúde e Meio Ambiente na atualidade. O mencionado colóquio pretendeu proporcionar aos participantes atividades de formação continuada de alto nível acadêmico e de intensa relevância social na área de saúde, de direito e do meio ambiente, fomentado reflexões sobre possíveis articulações e interfaces em tais campos de conhecimento. Para tanto, o evento foi dividido em dois blocos complementares com exposições orais de professores mestres, ex-bolsistas do Programa de Titulação Docente (PTDO) da UNIESP S.A. No primeiro bloco, enfatizaram-se discussões atuais e polêmicas a propósito da saúde. Já no segundo, abordaram-se aspectos legais e sociais do meio ambiente.
MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma
Creators: name: Smith, Aleisha M.
name: Wobker, Sara E.
name: Manocha, Ujjawal
name: Leung, Janet Y.
name: Parker, Joel S.
name: Pan, Xinchao
name: Williams, Lindsay A.
name: Peters, Dorien J.
name: Saito, Ryoichi
name: Kim, William Y.
name: Moffitt, Richard A.
name: Eaton, Samuel C.
name: Lee, Hyo Jin
name: Felsher, Dean W.
name: Kardos, Jordan
name: Krishnan, Bhavani
name: Yeh, Jen Jen
name: Carroll, Thomas J.
name: Walter, Vonn
name: Zhang, Jing
name: Wilson, Harper L.
name: Zhang, Qing
name: Bailey, Sean T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Renal carcinoma is a common and aggressive malignancy whose histopathogenesis is incompletely understood and that is largely resistant to cytotoxic chemotherapy. We present two mouse models of kidney cancer that recapitulate the genomic alterations found in human papillary (pRCC) and clear cell RCC (ccRCC), the most common RCC subtypes. MYC activation results in highly penetrant pRCC tumours (MYC), while MYC activation, when combined with Vhl and Cdkn2a (Ink4a/Arf) deletion (VIM), produce kidney tumours that approximate human ccRCC. RNAseq of the mouse tumours demonstrate that MYC tumours resemble Type 2 pRCC, which are known to harbour MYC activation. Furthermore, VIM tumours more closely simulate human ccRCC. Based on their high penetrance, short latency, and histologic fidelity, these models of papillary and clear cell RCC should be significant contributions to the field of kidney cancer research.
Population dynamics of Protea nitida and repens in Hottentots Holland, Grabouw, site 3418BB/15
Creators: name: Jonkershoek Forestry Research Center
Publisher: name: South African Environmental Observation Network
Year: 2022
Subjects: Jonkershoek Forestry Research Centre
Hottentots Holland
Population dynamics
Protea nitida
Grabouw
Protea repens

description: This is a scanned copy of the population dynamics of Protea nitida and repens in Hottentots Holland, Grabouw, site 3418BB/15. The Jonkershoek Forestry Research Center (part of the former South African Forestry Research Institute) was established in 1935 at Jonkershoek, near Stellenbosch, under the directorship of Dr C. L. Wicht. The initial aim was to determine how forestry activities in state plantations would affect climate, water conservation and erosion, and was later expanded to include studies of fynbos ecology, fire and alien species. Studies from the 1930s to the early 1990s saw the accumulation of a large amount of data dealing with fire experiments, detailed vegetation plot surveys, rare plant surveys and ecological studies, hydrological studies and the development of management plans for catchments around the Western Cape.  SAEON now houses the archive of data collected by the Jonkershoek Forestry Research Center, which was originally held by the Council for Scientific and Industrial Research (CSIR).
Majorana dark matter through the Higgs portal under the vacuum stability lamppost
Creators: name: Anchordoqui, Luis A.
name: Barger, Vernon
name: Goldberg, Haim
name: Huang, Xing
name: Marfatia, Danny
name: da Silva, Luiz H. M.
name: Weiler, Thomas J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We study the vacuum stability of a minimal Higgs portal model in which the standard model (SM) particle spectrum is extended to include one complex scalar field and one Dirac fermion. These new fields are singlets under the SM gauge group and are charged under a global U(1) symmetry. Breaking of this U(1) symmetry results in a massless Goldstone boson, a massive CP-even scalar, and splits the Dirac fermion into two new mass-eigenstates, corresponding to Majorana fermions. The lightest Majorana fermion (w) is absolutely stable, providing a plausible dark matter (DM) candidate. We show that interactions between the Higgs sector and the lightest Majorana fermion which are strong enough to yield a thermal relic abundance consistent with observation can easily destabilize the electroweak vacuum or drive the theory into a non-perturbative regime at an energy scale well below the Planck mass. However, we also demonstrate that there is a region of the parameter space which develops a stable vacuum (up to the Planck scale), satisfies the relic abundance, and is in agreement with direct DM searches. Such an interesting region of the parameter space corresponds to DM masses 350 GeV \alt m_w \alt 1 TeV. The region of interest is within reach of second generation DM direct detection experiments.
description: To be published in PRD
Supplementary documentation for SAEON's field instrument data collected at the Jonkershoek Lambrechtsbos B station
Creators: name: South African Environmental Observation Network (SAEON) Fynbos Node
Publisher: name: South African Environmental Observation Network
Year: 2022
Subjects: SAEON field instruments
Standard Operating Procedures
Calibration
Jonkershoek
Hydrological
Weir
Water level
water temperature

description: This package contains supporting information for the hydrological data collected at Jonkershoek's Lambrechtsbos B station, as part of the South African Environmental Observation Network's monitoring projects.
Proteogenomic integration reveals therapeutic targets in breast cancer xenografts
Creators: name: Qiao, Jana W
name: McLellan, Michael D.
name: Erdmann-Gilmore, Petra
name: Ellis, Matthew J.
name: Snider, Jacqueline E.
name: Hoog, Jeremy
name: Sun, Sam Qiancheng
name: Fenyö, David
name: Mesri, Mehdi
name: Ma, Cynthia
name: Ding, Li
name: Kavuri, Shyam M.
name: Xie, Ling
name: Kawaler, Emily
name: Ruggles, Kelly V.
name: Usary, Jerry
name: Held, Jason M.
name: Kinsinger, Christopher R.
name: Yoon, Christopher
name: Davies, Sherri R.
name: Wyczalkowski, Matthew A.
name: Li, Shunqiang
name: Gunawardena, Harsha P.
name: Mertins, Philipp
name: Tanioka, Maki
name: Wang, Xuya
name: Clauser, Karl R.
name: Sanati, Souzan
name: Gillette, Michael A.
name: Wendl, Michael C.
name: Wrobel, John
name: Ye, Kai
name: Huang, Kuan-Lin
name: Niu, Beifung
name: Reid Townsend,
name: Perou, Charles M.
name: Scott, Adam
name: Carr, Steven A.
name: Chen, Xian
name: Malovannaya, Anna
name: Mani,
name: Cao, Song
name: Guo, Zhanfang
name: Singh, Purba
name: Rodriguez, Henry
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Recent advances in mass spectrometry (MS) have enabled extensive analysis of cancer proteomes. Here, we employed quantitative proteomics to profile protein expression across 24 breast cancer patient-derived xenograft (PDX) models. Integrated proteogenomic analysis shows positive correlation between expression measurements from transcriptomic and proteomic analyses; further, gene expression-based intrinsic subtypes are largely re-capitulated using non-stromal protein markers. Proteogenomic analysis also validates a number of predicted genomic targets in multiple receptor tyrosine kinases. However, several protein/phosphoprotein events such as overexpression of AKT proteins and ARAF, BRAF, HSP90AB1 phosphosites are not readily explainable by genomic analysis, suggesting that druggable translational and/or post-translational regulatory events may be uniquely diagnosed by MS. Drug treatment experiments targeting HER2 and components of the PI3K pathway supported proteogenomic response predictions in seven xenograft models. Our study demonstrates that MS-based proteomics can identify therapeutic targets and highlights the potential of PDX drug response evaluation to annotate MS-based pathway activities.
Scrophularia crenophila Boiss., Diagn. Pl. Orient.
Creators: name: Uzunhisarcikli, M. Erkan
name: Güner, Ebru Doğan
name: Ekici, Murat
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Lamiales
Scrophulariaceae
Scrophularia
Scrophularia crenophila

description: 20. Scrophularia crenophila Boiss., Diagn. Pl. Orient. ser. 1(7): 41 (1846)
 Type: — [IRAN] ad fontes alpis Kuh‒Diiena Persia australis, Kotschy 632 (holotype G, isotype E, M, W!).
 Specimens seen: — TURKEY. Van: 20 km W of Erciş, 1900‒2200 m, 06 July 1982, R. R. Mill (WU 82‒43 ‒ 162); Erciş, Hasanabdal Village, streamsides, 1997 m, 31 August 2014, M. E. Uzunhisarcıklı 2651 (GAZI); ibid., 03 June 2015, M. E. Uzunhisarcıklı 2668 (GAZI).
 Flowering time:— June–August.
 Habitat:— Volcanic rocky slopes, streamsides. 1900‒2200 m elevation.
 Distribution:— Irano-Turanian element.
description: Published as part of Uzunhisarcikli, M. Erkan, Güner, Ebru Doğan & Ekici, Murat, 2018, Synopsis of the genus Scrophularia (Scrophulariaceae) in Turkey, pp. 151-187 in Phytotaxa 333 (2) on page 164, DOI: 10.11646/phytotaxa.333.2.1, http://zenodo.org/record/13721306
Photo plot in Langeberg, Riviersonderend - Boskloof, site 3419AB/1
Creators: name: Jonkershoek Forestry Research Center
Publisher: name: South African Environmental Observation Network
Year: 2022
Subjects: Jonkershoek Forestry Research Centre
photo plot
Langeberg
Riviersonderend
Boskloof

description: This is a scanned copy of a photo plot in Langeberg, Riviersonderend - Boskloof, site 3419AB/1. The Jonkershoek Forestry Research Center (part of the former South African Forestry Research Institute) was established in 1935 at Jonkershoek, near Stellenbosch, under the directorship of Dr C. L. Wicht. The initial aim was to determine how forestry activities in state plantations would affect climate, water conservation and erosion, and was later expanded to include studies of fynbos ecology, fire and alien species. Studies from the 1930s to the early 1990s saw the accumulation of a large amount of data dealing with fire experiments, detailed vegetation plot surveys, rare plant surveys and ecological studies, hydrological studies and the development of management plans for catchments around the Western Cape. SAEON now houses the archive of data collected by the Jonkershoek Forestry Research Center, which was originally held by the Council for Scientific and Industrial Research (CSIR).
title: Developing a Framework to Shape the Strategic Management of Social Media Activities for an Online Magazine
Creators: name: Calise, Giovanni
Publisher: name: University of Liverpool Repository
Year: 2020

description: A common problem amongst non-profit organizations is a lack of procedures guiding social media activities, often resulting in underperforming engagement level. Developing procedures to guide social media actions to overcome low engagement is a managerial problem that needs to be addressed by marketing managers and CMO’s. This thesis applies the action research approach to develop a framework for a non-profit online magazine to shape the strategic management of the organization’s volunteers through the actions of content creation and promotion on social media; resulting in the desired level of engagements. The resulting framework, the Social Media Conversation framework (SMC) which is applicable to the platforms of Twitter and Instagram, can be utilized to alleviate a managerial problem of CMO’s who are failing to obtain adequate social media engagements by providing recommendations that will be useful to making optimal decisions and procedures in respect to digital marketing campaigns based on the analysis of actual data. The SMC has three parts based upon diffusion theories. The first part guides content creators through the content creation process through the stages of topic selection, social monitoring, content style, and content format. The second part of the SMC provides a guide to maximize the social media platform while publishing a post through the use of text, hashtags, content, and self- promotion. The third part of the SMC provides an effective option for marketing managers to advertise Twitter posts through the use of keyword targeting promoted tweets. The actionable knowledge developed from this study was utilized by the magazine to establish procedures to manage the organization’s social media activities.
Sample composition alters associations between age and brain structure
Creators: name: Keyes, Katherine M.
name: McLaughlin, Katie A.
name: Sheridan, Margaret A.
name: Lewinn, Kaja Z.
name: Hamilton, Ava
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Despite calls to incorporate population science into neuroimaging research, most studies recruit small, non-representative samples. Here, we examine whether sample composition influences age-related variation in global measurements of gray matter volume, thickness, and surface area. We apply sample weights to structural brain imaging data from a community-based sample of children aged 3-18 (N = 1162) to create a "weighted sample" that approximates the distribution of socioeconomic status, race/ethnicity, and sex in the U.S. Census. We compare associations between age and brain structure in this weighted sample to estimates from the original sample with no sample weights applied (i.e., unweighted). Compared to the unweighted sample, we observe earlier maturation of cortical and sub-cortical structures, and patterns of brain maturation that better reflect known developmental trajectories in the weighted sample. Our empirical demonstration of bias introduced by non-representative sampling in this neuroimaging cohort suggests that sample composition may influence understanding of fundamental neural processes.The influence of sample composition on human neuroimaging results is unknown. Here, the authors weight a large, community-based sample to better reflect the US population and describe how applying these sample weights changes conclusions about age-related variation in brain structure.
The Simultaneous Metric Dimension of Families Composed by Lexicographic Product Graphs
Creators: name: Ramirez-Cruz, Yunior
name: Estrada-Moreno, Alejandro
name: Rodriguez-Velazquez, Juan A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05C12, 05C76

description: Let ${\mathcal G}$ be a graph family defined on a common (labeled) vertex set $V$. A set $S\subseteq V$ is said to be a simultaneous metric generator for ${\cal G}$ if for every $G\in {\cal G}$ and every pair of different vertices $u,v\in V$ there exists $s\in S$ such that $d_{G}(s,u)\ne d_{G}(s,v)$, where $d_{G}$ denotes the geodesic distance. A simultaneous adjacency generator for ${\cal G}$ is a simultaneous metric generator under the metric $d_{G,2}(x,y)=\min\{d_{G}(x,y),2\}$. A minimum cardinality simultaneous metric (adjacency) generator for ${\cal G}$ is a simultaneous metric (adjacency) basis, and its cardinality the simultaneous metric (adjacency) dimension of ${\cal G}$. Based on the simultaneous adjacency dimension, we study the simultaneous metric dimension of families composed by lexicographic product graphs.
Spectroscopic detection of halogen bonding resolves dye regeneration in the dye-sensitized solar cell
Creators: name: Berlinguette, Curtis P.
name: Parlane, Fraser G. L.
name: Kellett, Cameron W.
name: Kennepohl, Pierre
name: Simon, Sarah J.
name: Meyer, Gerald J.
name: Mustoe, Chantal
name: Swords, Wesley B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: The interactions between a surface-adsorbed dye and a soluble redox-active electrolyte species in the dye-sensitized solar cell has a significant impact on the rate of regeneration of photo-oxidized dye molecules and open-circuit voltage of the device. Dyes must therefore be designed to encourage these interfacial interactions, but experimentally resolving how such weak interactions affect electron transfer is challenging. Herein, we use X-ray absorption spectroscopy to confirm halogen bonding can exist at the dye-electrolyte interface. Using a known series of triphenylamine-based dyes bearing halogen substituents geometrically positioned for reaction with halides in solution, halogen bonding was detected only in cases where brominated and iodinated dyes were photo-oxidized. This result implies that weak intermolecular interactions between photo-oxidized dyes and the electrolyte can impact device photovoltages. This result was unexpected considering the low concentration of oxidized dyes (less than 1 in 100,000) under full solar illumination.
Scrophularia scariosa Boiss., Diagn. Pl. Orient.
Creators: name: Uzunhisarcikli, M. Erkan
name: Güner, Ebru Doğan
name: Ekici, Murat
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Lamiales
Scrophulariaceae
Scrophularia
Scrophularia scariosa

description: 23. Scrophularia scariosa Boiss., Diagn. Pl. Orient. ser. 1(4): 67 (1844)
 Type: — [TURKEY. C 6 Gaziantep /Syria] in Syria prope Alep et Antab (Gaziantep), Aucher 1765 (holotype G, isotype K!).
 Specimens seen: — TURKEY. Adıyaman: Gölbaşı, around of İnekli Lake, damp disturbed areas, ca. 900 m, 13 May 2017, M. E. Uzunhisarcıklı 2716 (GAZI); ibid., 06 July 2017, M. E. Uzunhisarcıklı 2719 (GAZI); ibid., 05 April 2008, A. İlçim 1746 (VANF).
 Flowering time:— May–June.
 Habitat:— Damp degraded areas. c. 900 m elevation.
 Distribution:— Irano-Turanian element.
description: Published as part of Uzunhisarcikli, M. Erkan, Güner, Ebru Doğan & Ekici, Murat, 2018, Synopsis of the genus Scrophularia (Scrophulariaceae) in Turkey, pp. 151-187 in Phytotaxa 333 (2) on page 166, DOI: 10.11646/phytotaxa.333.2.1, http://zenodo.org/record/13721306
title: ACTION RESEARCH STUDY FOCUSED ON FRAMEWORK DEVELOPMENT FOR IMPLEMENTATION OF A REAL-TIME PERFORMANCE MANAGEMENT SYSTEM WITHIN A MANUFACTURING ENVIRONMENT
Creators: name: Vibhu Prakash, Vijayalakshmi
Publisher: name: University of Liverpool Repository
Year: 2026

description: Purpose – Performance management is a vital function that helps assess individual performance and strengthen job clarity and outcomes. Within the framework of performance management, human resources (HR) elements such as specific, measurable, actionable, realistic and timebound (SMART) goals setting, alignment of goals to strategy, vision and mission, collaborative shared goal setting, supportive leadership, simple transparent systems, engagement, frequent appraisal, and feedback, coaching and mentoring, training and development, communication, and HR System integration across units, all play a critical role and contribute to effective real-time performance management. Approach - Three cycles of action inquiry were used to understand the problem, identify 11 elements within a framework model to use in performance management through multi-stage data collection strategy, applying mixed methods. The triangulation of outcomes helped understand and examine alternatives for developing a framework that supported sequential implementation of performance management elements within a manufacturing setting. Outcomes and recommendations –The action inquiry established the necessity of the 11 elements, and study concluded that inter-dependence of the 11 elements necessitates a sequential framework for implementation to achieve real-time performance management objectives. Conclusion – The inter-dependence of the elements and their multi-dimensionality require that the elements be understood and structurally executed in sequence for successful implementation. Issues and suggestions detailed in the following chapters are not conclusive or exhaustive. Other dependent elements can be listed, but this project attributed its focus on the issues of performance management through the lens of the 11 elements. While attempting a futuristic implementation strategy, and the research sought to not repeat what has been researched earlier.
Tissue-specific expression patterns of resistance genes: A comparative study of legume NLR receptors
Creators: name: Marques, Rita Maravilha
name: Santos, Carmen
name: Pai, Hsuan
name: Patto, Carlota Vaz
name: Kamoun, Sophien
name: Kourelis, Jiorgos
Publisher: name: Zenodo
Year: 2023

description: Poster presented at the International Legume Society Conference (ILS Granada).
title: Les piscines intérieures
Creators: name: Garden, G. K.
Publisher: name: Conseil national de recherches du Canada. Division des recherches en construction
Year: 1967
Subjects: subject: indoor swimming pools
subject: piscine couverte
subject: temperature
subject: température
subject: humidity
subject: humidité
subject: surface condensation
subject: condensation superficielle
subject: air leakages
subject: penétration de l'air
subject: mechanical ventilation
subject: ventilation mécanique

description: L'auteur expose les conditions nécessaires au comfort des usagers des piscines intérieures; il définit la température et le degré hygrométrique qui devraient régner à l'intérieur de ces bâtiments. Il examine les mesures qu'il faudrait prendre à cette fin et l'effet qu'elles auraient sur les matériaux de construction; il propose ensuite certaines solutions qui permettraient de réaliser une enceinte concue de facon à éviter ces difficultés.
The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand
Creators: name: Stoltz, Kristen
name: Roth, Bryan L.
name: McCorvy, John D.
name: Marchant, Jonathan S.
name: Cupit, Pauline M.
name: Gunaratne, Gihan S.
name: Webb, Thomas R.
name: Abagyan, Ruben
name: Cunningham, Charles
name: Yang, Yang
name: Chan, John D.
name: Dosa, Peter I.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Schistosomiasis is a debilitating tropical disease caused by infection with parasitic blood flukes. Approximately 260 million people are infected worldwide, underscoring the clinical and socioeconomic impact of this chronic infection. Schistosomiasis is treated with the drug praziquantel (PZQ), which has proved the therapeutic mainstay for over three decades of clinical use. However, the molecular target(s) of PZQ remain undefined. Here we identify a molecular target for the antischistosomal eutomer - (R)-PZQ - which functions as a partial agonist of the human serotoninergic 5HT2B receptor. (R)-PZQ modulation of serotoninergic signaling occurs over a concentration range sufficient to regulate vascular tone of the mesenteric blood vessels where the adult parasites reside within their host. These data establish (R)-PZQ as a G-protein-coupled receptor ligand and suggest that the efficacy of this clinically important anthelmintic is supported by a broad, cross species polypharmacology with PZQ modulating signaling events in both host and parasite.