cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Genotype to phenotype mapping and the fitness landscape of the E. coli lac promoter
Creators: name: Otwinowski, Jakub
name: Nemenman, Ilya
Publisher: name: arXiv
Year: 2012
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: Genomics (q-bio.GN)
subject: FOS: Biological sciences

description: Genotype-to-phenotype maps and the related fitness landscapes that include epistatic interactions are difficult to measure because of their high dimensional structure. Here we construct such a map using the recently collected corpora of high-throughput sequence data from the 75 base pairs long mutagenized E. coli lac promoter region, where each sequence is associated with its phenotype, the induced transcriptional activity measured by a fluorescent reporter. We find that the additive (non-epistatic) contributions of individual mutations account for about two-thirds of the explainable phenotype variance, while pairwise epistasis explains about 7% of the variance for the full mutagenized sequence and about 15% for the subsequence associated with protein binding sites. Surprisingly, there is no evidence for third order epistatic contributions, and our inferred fitness landscape is essentially single peaked, with a small amount of antagonistic epistasis. There is a significant selective pressure on the wild type, which we deduce to be multi-objective optimal for gene expression in environments with different nutrient sources. We identify transcription factor (CRP) and RNA polymerase binding sites in the promotor region and their interactions without difficult optimization steps. In particular, we observe evidence for previously unexplored genetic regulatory mechanisms, possibly kinetic in nature. We conclude with a cautionary note that inferred properties of fitness landscapes may be severely influenced by biases in the sequence data.
Mass ratio of elementary excitations in frustrated antiferromagnetic chains with dimerization
Creators: name: Takayoshi, Shintaro
name: Oshikawa, Masaki
Publisher: name: arXiv
Year: 2012
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Excitation spectra of S=1/2 and S=1 frustrated Heisenberg antiferromagnetic chains with bond alternation (explicit dimerization) are studied using a combination of analytical and numerical methods. The system undergoes a dimerization transition at a critical bond alternation parameter $δ=δ_{\rm c}$, where $δ_{\rm c} = 0$ for the S=1/2 chain. The SU(2)-symmetric sine-Gordon theory is known to be an effective field theory of the system except at the transition point. The sine-Gordon theory has a SU(2)-triplet and a SU(2)-singlet of elementary excitation, and the mass ratio $r$ of the singlet to the triplet is $\sqrt{3}$. However, our numerical calculation with the infinite time-evolving block decimation method shows that $r$ depends on the frustration (next-nearest-neighbor coupling) and is generally different from $\sqrt{3}$. This can be understood as an effect of marginal perturbation to the sine-Gordon theory. In fact, at the critical frustration separating the second-order and first-order dimerization transitions, the marginal operator vanishes and $r=\sqrt{3}$ holds. We derive the mass ratio $r$ analytically using form-factor perturbation theory combined with a renormalization-group analysis. Our formula agrees well with the numerical results, confirming the theoretical picture. The present theory also implies that, even in the presence of a marginally irrelevant operator, the mass ratio approaches $\sqrt{3}$ in the very vicinity of the second-order dimerization critical point $δ\sim δ_c$. However, such a region is extremely small and would be difficult to observe numerically.
description: 7 pages, 5 figures
Longitudinal Relationships between Alzheimer Disease Progression and Psychosis, Depressed Mood, and Agitation/Aggression
Creators: name: Zahodne, Laura B.
name: Ornstein, Katherine
name: Cosentino, Stephanie
name: Devanand, Devangere P.
name: Stern, Yaakov
Publisher: name: Columbia University
Year: 2015
Subjects: Alzheimer's disease
Dementia
Depression, Mental
Psychosis
Geriatric psychiatry

description: OBJECTIVES: Behavioral and psychological symptoms of dementia (BPSD) are prevalent in Alzheimer disease (AD) and are related to poor outcomes such as nursing home placement. No study has examined the impact of individual BPSD on dependence, a clinically important feature that reflects changing patient needs and their effect on caregivers. The current study characterized independent cross-sectional and longitudinal relationships between three BPSD (psychosis, depressed mood, and agitation/aggression), cognition, and dependence to better understand the interplay between these symptoms over time. DESIGN: The Predictors Study measured changes in BPSD, cognition, and dependence every 6 months in patients with AD. Cross-sectional and longitudinal relationships between individual BPSD, cognition, and dependence over 6 years were characterized by using multivariate latent growth curve modeling. This approach characterizes independent changes in multiple outcome measures over time. SETTING: Four memory clinics in the United States and Europe. PARTICIPANTS: A total of 517 patients with probable AD. MEASUREMENTS: Columbia University Scale for Psychopathology, modified Mini-Mental State Examination, and Dependence Scale. RESULTS: Both psychosis and depressed mood at study entry were associated with worse subsequent cognitive decline. Independent of cognitive decline, initial psychosis was associated with worse subsequent increases in dependence. Rates of increase in agitation/aggression separately correlated with rates of declines in both cognition and independence. CONCLUSIONS: Although purely observational, our findings support the poor prognosis associated with psychosis and depression in AD. Results also show that agitation/aggression tracks declines in cognition and independence independently over time. Targeted intervention for individual BPSD, particularly psychosis, could have broad effects not only on patient well-being but also on care costs and family burden.
The 22nd Gerald Dunning Memorial Lecture: The Many Faces of Pottery: Finds of Mediterranean Ceramics and Sets of Drinking Vessels in Late Medieval Flanders (Belgium)
Creators: name: De Groote, Koen
Publisher: name: Archaeology Data Service
Year: 2023

description: Medieval Ceramics: Journal of the Medieval Ceramics Research Group, 41, 1-16
description: This paper focuses on two of the topics considered in the 2018 Gerald Dunning Memorial lecture on the composition of pottery assemblages as socio-economic indicators. One theme is religious, the other secular; both are illustrated using recent case studies from different Flemish sites. The main emphasis is on the significance of Mediterranean pottery in t'arious late medieval contexts in Flanders and the religious background to its circulation; building on an earlier paper (published in 2014), it considers new discoveries and how they contribute to the discussion of this subject. The second theme, by contrast, considers pottery from an urban site, discussing groups of drinking vessels (both pottery and glass) from three cesspits on the property of a crossbow maker and the communal context in which they may have been used.
The XMM Cluster Survey: Evidence for energy injection at high redshift from evolution of the X-ray luminosity-temperature relation
Creators: name: Hilton, Matt
name: Romer, A. Kathy
name: Kay, Scott T.
name: Mehrtens, Nicola
name: Lloyd-Davies, E. J.
name: Thomas, Peter A.
name: Short, Chris J.
name: Mayers, Julian A.
name: Rooney, Philip J.
name: Stott, John P.
name: Collins, Chris A.
name: Harrison, Craig D.
name: Hoyle, Ben
name: Liddle, Andrew R.
name: Mann, Robert G.
name: Miller, Christopher J.
name: Sahlen, Martin
name: Viana, Pedro T. P.
name: Davidson, Michael
name: Hosmer, Mark
name: Nichol, Robert C.
name: Sabirli, Kivanc
name: Stanford, S. A.
name: West, Michael J.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We measure the evolution of the X-ray luminosity-temperature (L_X-T) relation since z~1.5 using a sample of 211 serendipitously detected galaxy clusters with spectroscopic redshifts drawn from the XMM Cluster Survey first data release (XCS-DR1). This is the first study spanning this redshift range using a single, large, homogeneous cluster sample. Using an orthogonal regression technique, we find no evidence for evolution in the slope or intrinsic scatter of the relation since z~1.5, finding both to be consistent with previous measurements at z~0.1. However, the normalisation is seen to evolve negatively with respect to the self-similar expectation: we find E(z)^{-1} L_X = 10^{44.67 +/- 0.09} (T/5)^{3.04 +/- 0.16} (1+z)^{-1.5 +/- 0.5}, which is within 2 sigma of the zero evolution case. We see milder, but still negative, evolution with respect to self-similar when using a bisector regression technique. We compare our results to numerical simulations, where we fit simulated cluster samples using the same methods used on the XCS data. Our data favour models in which the majority of the excess entropy required to explain the slope of the L_X-T relation is injected at high redshift. Simulations in which AGN feedback is implemented using prescriptions from current semi-analytic galaxy formation models predict positive evolution of the normalisation, and differ from our data at more than 5 sigma. This suggests that more efficient feedback at high redshift may be needed in these models.
description: Accepted for publication in MNRAS; 12 pages, 6 figures; added references to match published version
Personal a/r/tographic narratives of cultural displacement : in Latino American immigrants living in Canada
Creators: name: Rodriguez Naranjo, Gloria Estella
Publisher: name: University of British Columbia
Year: 2012

description: Immigration is the act of moving to and settling into a new country. It means starting again while leaving many people and things behind. This phenomenon has been embraced, embodied, lived, celebrated and suffered by many people for various reasons throughout history. Factors such as war and political oppression, poor living conditions, economic opportunity and stability are explanations for why people decide to leave their native countries. Therefore, immigration embodies loss of one’s culture but at the same time embodies celebration for enhanced opportunities, when arriving and adjusting to the codes of a new system. Understanding cultural displacement as the sensation of being in a third space, of having to re-invent yourself again, adjusting day-by-day to a new culture, this study examines how Latin American immigrants to Canada confront cultural displacement. Applying a/r/tography and photo-elicitation as research methodologies the study sets up conditions for participants to engage and construct meaning together about being away from home. This research analyzes the extent to which Latin American immigrants to Canada negotiate being in-between these two spaces (their country of origin and Canada). It does this primarily through the creation of a series of photographs and conversations. Some of the findings reveal that indeed Latin American immigrants acknowledge that the process of settlement in a foreign land is complicated and it takes time to adjust and understand the culture. At the same time Latin American immigrants admit the importance of comprehending, cultivating and embracing Canadian culture, in order to merge easily in its communities. Similarly, the findings unfold the way participants created their own version of what it means to be Canadians rather than learning simply from others about its significance. As immigrants, the group I studied kept some features of Latin cultures alive in Canada, in this way, the study presents a new understanding of what is possible while dwelling in the in-between.
Medieval Face Jugs from Lodose, Sweden. Where Were They Made?
Creators: name: Brorsson, Torbj�Rn
name: Jeffery, Soma
Publisher: name: Archaeology Data Service
Year: 2023

description: Medieval Ceramics: Journal of the Medieval Ceramics Research Group, 41, 55-66
description: Ceramic jugs with anthropomorphic decoration can be found in almost every medieval town in Northern Europe and they are generally dated to around 1250-1350. Most examples found in Scandinavia seem to be of German origin, but English jugs also occur. This paper deals with sherds from 12 such jugs found in the medieval town of Lodose, West Sweden, which were analysed using ICP-MA/ES in order to establish their provenance and whether they might have been locally made. The results show that most came from the former Hanseatic city of Litbeck, but there are also jugs from other regions in Northern Europe. The study forms part of a major project dealing with over 43,000 potsherds from the town of Lodose.
Is a system's wave function in one-to-one correspondence with its elements of reality?
Creators: name: Colbeck, Roger
name: Renner, Renato
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Although quantum mechanics is one of our most successful physical theories, there has been a long-standing debate about the interpretation of the wave function---the central object of the theory. Two prominent views are that (i) it corresponds to an element of reality, i.e. an objective attribute that exists before measurement, and (ii) it is a subjective state of knowledge about some underlying reality. A recent result [Pusey et al. arXiv:1111.3328] has placed the subjective interpretation into doubt, showing that it would contradict certain physically plausible assumptions, in particular that multiple systems can be prepared such that their elements of reality are uncorrelated. Here we show, based only on the assumption that measurement settings can be chosen freely, that a system's wave function is in one-to-one correspondence with its elements of reality. This also eliminates the possibility that it can be interpreted subjectively.
description: 4 pages plus 2 of appendix
Entanglement in a three spin system controlled by electric and magnetic field
Creators: name: Luczak, Jukub
name: Bulka, Bogdan R.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We show influence of electric field and magnetic flux on spin entanglement in an artificial triangular molecule build of coherently coupled quantum dots. In a subspace of doublet states an explicit relation of concurrence with spin correlation functions and chirality is presented. The electric field modifies super-exchange correlations, shifts many-electron levels (the Stark effect) as well as changes spin correlations. For some specific orientation of the electric field one can observe monogamy, for which one of the spins is separated from two others. Moreover, the Stark effect manifests itself in different spin entanglement for small and strong electric fields. A role of magnetic flux is opposite, it leads to circulation of spin supercurrents and spin delocalization.
description: 7 pages, 8 figures
Longitudinal Medication Usage in Alzheimer Disease Patients
Creators: name: Zhu, Carolyn W.
name: Livote, Elayne E.
name: Kahle-Wrobleski, Kristin
name: Scarmeas, Nikolaos
name: Albert, Marilyn
name: Brandt, Jason
name: Blacker, Deborah
name: Sano, Mary
name: Stern, Yaakov
Publisher: name: Columbia University
Year: 2010
Subjects: Cholinesterase inhibitors
Alzheimer's disease--Treatment
Longitudinal studies
Medicine
Neurology

description: This study examined in detail patterns of cholinesterase inhibitors (ChEIs) and memantine use and explored the relationship between patient characteristics and such use. Patients with probable Alzheimer disease AD (n=201) were recruited from the Predictors Study in 3 academic AD centers and followed from early disease stages for up to 6 years. Random effects logistic regressions were used to examine effects of patient characteristics on ChEIs/memantine use over time. Independent variables included measures of function, cognition, comorbidities, the presence of extrapyramidal signs, psychotic symptoms, age, sex, and patient's living situation at each interval. Control variables included assessment interval, year of study entry, and site. During a 6-year study period, rate of ChEIs use decreased (80.6% to 73.0%) whereas memantine use increased (2.0% to 45.9%). Random effects logistic regression analyses showed that ChEI use was associated with better function, no psychotic symptoms, and younger age. Memantine use was associated with better function, poorer cognition, living at home, later assessment interval, and later year of study entry. Results suggest that high rate of ChEI use and increasing memantine use over time are consistent with current practice guidelines of initiation of ChEIs in mild-to-moderate AD patients and initiation of memantine in moderate-to-severe patients.
Effect of Piezoelectric Polarization on Phonon group velocity in Wurtzite Nitrides
Creators: name: Sahoo, Bijaya Kumar
Publisher: name: arXiv
Year: 2011
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We have investigated the effect of piezoelectric (PZ) polarization property on group velocity of phonons in binary as well as in ternary wurtzite nitrides. It is found that with the presence of PZ polarization property, the phonon group velocity is modified. The change in phonon group velocity due to PZ polarization effect directly depends on piezoelectric tensor value. Using different piezoelectric tensor values recommended by different workers in the literature, percent change in group velocities of phonons has been estimated. The Debye temperatures and frequencies of binary nitrides GaN, AlN and InN are also calculated using the modified group velocities. For ternary nitrides AlxGa(1-x)N, InxGa(1-x)N and InxAl(1-x)N, the phonon group velocities have been calculated as a functions of composition. A small positive bowing is observed in phonon group velocities of ternary alloys. Percent variations in phonon group velocities are also calculated for a straightforward comparison among ternary nitrides. The results are expected to show a change in phonon relaxation rates and thermal conductivity of III-nitrides when piezoelectric polarization property is taken into account.
description: 05 figures; Journal of Material science, 2011
Pseudopalaemon gouldingi Kensley & Walker 1982
Creators: name: Santos, Maria Aparecida Laurindo dos
name: Castro, Patrícia Madedo de
name: Magalhães, Célio
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Palaemonidae
Pseudopalaemon
Pseudopalaemon gouldingi

description: Pseudopalaemon gouldingi Kensley & Walker, 1982 (Figs 5D–F, 11) Identification characters (Fig. 5D–F). Rostrum short, arched over the eyes, as long as distal margin of scaphocerite; rostral formula: 8–13(2–3 post-orbital teeth)/1–3. Carapace smooth, with antennal and hepatic teeth present, branchiostegal suture indistinct; abdomen smooth, with pleura of second somite enlarged and overlapping pleuron of first and third somites. Telson with posterior margin triangular, ending in a distinct acute point, clearly overreached by inner pair of posterolateral spines. P2 similar in shape and size, chela as long as carpus. Material examined. 11 females, 1 immat. spec. (INPA 2320), Bonfim, BR 401 road, igarapé Arraia, tributary of rio Tacutu, 03°21ʹ05ʺ N, 059°54ʹ12ʺ W, 25-XI-1996, colls. V. Py-Daniel et al. Distribution. Brazil (Amazonas, Roraima [new record]) (Kensley and Walker, 1982; present study). The distribution in Roraima is depicted in Figure 11. Remarks. In general, the morphology of our specimens agrees well the description provided by Kensley and Walker (1992). However, the curvature of the rostrum over the eyes (Fig. 5D) seems to be a little less pronounced in the specimens from Roraima than those from the Negro River basin (see Kensley and Walker 1982: 18, fig. 20)
description: Published as part of Santos, Maria Aparecida Laurindo dos, Castro, Patrícia Madedo de & Magalhães, Célio, 2018, Freshwater shrimps (Crustacea, Decapoda, Caridea, Dendrobranchiata) from Roraima, Brazil: species composition, distribution, and new records, pp. 21-35 in Check List (Washington, D. C.: 1974) (Washington, D. C.: 1974) 14 (1) on page 31, DOI: 10.15560/14.1.21
description: {"references": ["Kensley B, Walker I (1982) Palaemonid shrimps from the Amazon basin, Brazil (Crustacea: Decapoda: Natantia). Smithsonian Contribution to Zoology 362: 1 - 28.", "Hansen HJ (1919) The Sergestidae of the Siboga Expedition. Siboga Expeditie 38: 1 - 65, pls. 1 - 5. Heller C (1862) Beitrage zur naheren Kenntniss der Macrouren. Sitzungsberichte der Mathematisch- Naturwissenschaftlichen Klasse der Kaiserlichen Akademie der Wissenschaften, Wien 45 (1): 389 - 426, pls 1 - 2.", "Calman WT (1907) On a freshwater decapod crustacean collected by W. J. Burchell at Para in 1829. The Annals and Magazine of Natural History (series 7) 19: 295 - 299."]}
Short Distance Freedom of Quantum Gravity
Creators: name: Narain, Gaurav
name: Anishetty, Ramesh
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Fourth order derivative gravity in 3+1-dimensions is perturbatively renormalizable and is shown to describe a unitary theory of gravitons in a limited coupling parameter space. The running gravitational constant which includes graviton contribution is computed. Generically, gravitational Newton's constant vanishes at short distances in this perturbatively renormalizable and unitary theory.
description: 8 pages, 2 figures, abstract modified, a paragraph added, new references added, typos corrected, version to appear in Physics Letter B
Dissipation effects in random transverse-field Ising chains
Creators: name: Hoyos, J. A.
name: Vojta, Thomas
Publisher: name: arXiv
Year: 2012
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We study the effects of Ohmic, super-Ohmic, and sub-Ohmic dissipation on the zero-temperature quantum phase transition in the random transverse-field Ising chain by means of an (asymptotically exact) analytical strong-disorder renormalization-group approach. We find that Ohmic damping destabilizes the infinite-randomness critical point and the associated quantum Griffiths singularities of the dissipationless system. The quantum dynamics of large magnetic clusters freezes completely which destroys the sharp phase transition by smearing. The effects of sub-Ohmic dissipation are similar and also lead to a smeared transition. In contrast, super-Ohmic damping is an irrelevant perturbation; the critical behavior is thus identical to that of the dissipationless system. We discuss the resulting phase diagrams, the behavior of various observables, and the implications to higher dimensions and experiments.
description: 18 pages, 3 figures; (v2) minor changes, published version
title: Learning Approach to the Active Compliance Control of Multi-Arm Robots Coupled through a Flexible Object
Creators: name: Albrichsfeld, Christian von
name: Svinin, Mikhail
name: Tolle, Henning
Publisher: name: UNSPECIFIED
Year: 2021

description: This paper presents a quasi-static model and a control strategy for N robot arms cooperating through a concerning its compliant behaviour partly unknown flexible object. The control strategy is based on the position/force decomposition of an extended 6N-dimensional space. The strategy includes feedforward and feedback levels. The Feedback level is organized in the form of an active compliance control law. An AMS-based learning approach is used to accommodate the compliance behaviour of the system and utilized as an additional feedforward loop in the control system. The applicability of the control strategy is verified by simulation.
Effect of Oestrogen During Menopause on Risk and Age at Onset of Alzheimer's Disease
Creators: name: Tang, Mingxin
name: Jacobs, Diane
name: Stern, Yaakov
name: Marder, Karen
name: Schofield, Peter R.
name: Gurland, Barry J.
name: Andrews, Howard F.
name: Mayeux, Richard Paul
Publisher: name: Columbia University
Year: 1996
Subjects: Neurology
Alzheimer's disease
Estrogen--Physiological effect
Menopause

description: Background Oestrogen use by postmenopausal women has many health benefits, but findings on the effect of oestrogen in Alzheimer's disease are conflicting. Oestrogen promotes the growth and survival of cholinergic neurons and could decrease cerebral amyloid deposition, both of which may delay the onset or prevent Alzheimer's disease. To investigate whether use of oestrogen during the postmenopausal period affects the risk of Alzheimer's disease, we studied 1124 elderly women who were initially free of Alzheimer's disease, Parkinson's disease, and stroke, and who were taking part in a longitudinal study of ageing and health in a New York City community. Methods Relative risks and age-at-onset distributions were calculated from simple and adjusted Cox proportional hazards models. Standard annual clinical assessments and criterion-based diagnoses were used in follow-up (range 1–5 years). Findings Overall, 156 (12·5%) women reported taking oestrogen after onset of menopause. The age at onset of Alzheimer's disease was significantly later in women who had taken oestrogen than in those who did not and the relative risk of the disease was significantly reduced (9/156 [5·8%] oestrogen users vs 158/968 [16·3%] non-users; 0·40 [95% CI 0·22–0·85], p<0 01), even after adjustment for differences in education, ethnic origin, and apolipoprotein-E genotype. Women who had used oestrogen for longer than 1 year had a greater reduction in risk; none of 23 women who were taking oestrogen at study enrolment has developed Alzheimer's disease. Interpretation Oestrogen use in postmenopausal women may delay the onset and decrease the risk of Alzheimer's disease. Prospective studies are needed to establish the dose and duration of oestrogen required to provide this benefit and to assess its safety in elderly postmenopausal women.
Bruhat graphs and pattern avoidance
Creators: name: Conklin, Christopher
name: Woo, Alexander
Publisher: name: arXiv
Year: 2011
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05C25, 05A05, 05E15

description: We characterize permutations whose Bruhat graphs can be drawn in the plane and those whose Bruhat graphs can be drawn in the torus. In particular, we show these properties are characterized by avoiding finitely many permutations.
description: 8 pages; new version adds torus characterization and deletes section on length whose results had previously appeared in literature
A Find of Medieval Pottery in Tresco Channel, Isles of Scilly
Creators: name: Allan, John
name: Brown, Duncan L
name: Camidge, Kevin
name: J Hughes, Michael
Publisher: name: Archaeology Data Service
Year: 2023

description: Medieval Ceramics: Journal of the Medieval Ceramics Research Group, 41, 17-54
description: The assemblage of pottery recovered from Tresco Channel, Isles of Scilly, is by far the largest underwater find of medieval ceramics ever made off British waters and is arguably one of the most important medieval pottery finds of recent years in the British Isles. The collection is dominated by Trench wares, with about half the sherds coming from the Saintonge, about 20% from the lower Seine Valley/Normandy, and a little from Brittany. English pottery makes up most of the other material, the principal sources being central southern England (probably representing trade with Southampton) and the Bristol area, but there are also finds from Cornwall, the Exeter area and other sites in south-west England. Current dating of some of the ware types represented is not entirely consistent; a case is made for dating most of the material to c 1250-80, with some earlier sherds. Programmes of ICP analysis have been carried out on the Saintonge and northern French wares - the former the most substantial programme of chemical analysis of such imports undertaken in the UK. Petrological and ICP analyses also throw light on a number of classes of southern English medieval pottery. The find offers dramatic physical evidence for the role of the Isles of Scilly in the medieval shipping routes between France, Britain, Ireland and Iberia, for which some documentary evidence also survives, while the associated wooden bale pins link the deposit to the wool trade. The pronounced concentration of sherds in a single place, and the fact that all the Saintonge wares which were sampled display a specific chemistry indicating that they come from the same group of kilns, favour the explanation that most of the ceramics represent a single event - either a shipwreck or the loss or disposal of a cargo. So far, however, only limited evidence for the presence of a ship has been found.
Plane waveguides with corners in the small angle limit
Creators: name: Dauge, Monique
name: Raymond, Nicolas
Publisher: name: arXiv
Year: 2012
Subjects: subject: Analysis of PDEs (math.AP)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: The plane waveguides with corners considered here are infinite V-shaped strips with constant thickness. They are parametrized by their sole opening angle. We study the eigenpairs of the Dirichlet Laplacian in such domains when this angle tends to 0. We provide multi-scale asymptotics for eigenpairs associated with the lowest eigenvalues. For this, we investigate the eigenpairs of a one-dimensional model which can be viewed as their Born-Oppenheimer approximation. We also investigate the Dirichlet Laplacian on triangles with sharp angles. The eigenvalue asymptotics involve powers of the cube root of the angle, while the eigenvector asymptotics include simultaneously two scales in the triangular part, and one scale in the straight part of the guides.
Effect of Age, Ethnicity, and Head Injury on the Association between APOE Genotypes and Alzheimer's Disease
Creators: name: Tang, Mingxin
name: Maestre, Gladys
name: Tsai, Wei-Yann
name: Liu, Xinhua
name: Feng, Lin
name: Chung, Wai-Yee
name: Chun, Michael
name: Schofield, Peter R.
name: Stern, Yaakov
name: Tycko, Benjamin
name: Mayeux, Richard Paul
Publisher: name: Columbia University
Year: 1996
Subjects: subject: Head--Wounds and injuries--Complications
subject: Apolipoprotein E
subject: Alzheimer's disease
subject: Neurosciences
subject: FOS: Clinical medicine

description: The apolipoprotein E (APOE)-e4 allele is neither necessary nor sufficient to cause Alzheimer's disease (AD) because it develops in the absence of APOE e4, and some persons escape the disease despite having an APOE €4 allele. Although the presence of the €4 allele of the APOE gene has been consistently associated with an increased risk of it is apparent that the degree of risk may be modified by age, gender, ethnic group, certain risk factors, and possibly other genes. Roses et al. proposed that APOE genotypes have a direct influence on the age at onset of disease. In both familial and sporadic AD, an earlier age at onset among APOE €4 homozygous and APOE €4 heterozygous cases than among those cases with other APOE genotypes. Thus, it is possible that APOE genotypes strongly influence age at onset and that certain factors, both genetic and nongenetic, modify this effect by shifting the distribution curves. In this review we will discuss demographic and putative risk factors that may modify (enhance or diminish) the association between APOE genotypes and AD.
vantVeld_SystematicEvaluation_Supplement.pdf
Creators: name: van 't Veld, Ronald
Publisher: name: figshare
Year: 2021
Subjects: subject: 90302 Biomechanical Engineering
subject: FOS: Medical engineering

description: Supplementary Tables: "Disentangling acceleration-, velocity- and duration-dependency of the short- and medium-latency stretch reflexes in the ankle plantarflexors"
YASHIL ENERGETIKA VA AQLLI TARMOQLARNI BOSHQARISHDA SUN'IY INTELLEKT ROLI
Creators: name: Qodirov, Farrux
name: Turayeva, Sabrina
Publisher: name: Zenodo
Year: 2025

description: Hozirgi davrda iqlim o'zgarishlari va energiya resurslarini tejash masalalari global muammolar qatoriga kiradi. Shu boisdan yashil energetika va aqlli tarmoqlar (smart grids) rivojlanishi zamonaviy texnologiyalar, xususan, sun’iy intellekt (SI) yordamida yanada samarali amalga oshirilmoqda. Ushbu maqolada sun’iy intellektning yashil energetika va aqlli tarmoqlarni boshqarishda tutgan o‘rni, afzalliklari va imkoniyatlari yoritib beriladi.
Dynamic Patterns of Brain Structure-Behavior Correlation across the Lifespan
Creators: name: Razlighi, Qolamreza R.
name: Oh, Hwamee
name: Habeck, Christian G.
name: O'Shea, Deirdre
name: Gazes, Elaine
name: Eich, Teal
name: Parker, David B.
name: Lee, Seonjoo
name: Stern, Yaakov
Publisher: name: Columbia University
Year: 2016
Subjects: subject: Neurology
subject: Aging
subject: Neurosciences
subject: FOS: Clinical medicine
subject: Cognitive neuroscience
subject: Brain--Aging

description: Although the brain/behavior correlation is one of the premises of cognitive neuroscience, there is still no consensus about the relationship between brain measures and cognitive function, and only little is known about the effect of age on this relationship. We investigated the age-associated variations on the spatial patterns of cortical thickness correlates of four cognitive domains. We showed that the spatial distribution of the cortical thickness correlates of each cognitive domain is distinctive and depicts varying age-association differences across the adult lifespan. Specifically, the present study provides evidence that distinct cognitive domains are associated with unique structural patterns in three adulthood periods: Early, middle, and late adulthood. These findings suggest a dynamic interaction between multiple neural substrates supporting each cognitive domain across the adult lifespan.
Markovian Dynamics on Complex Reaction Networks
Creators: name: Goutsias, John
name: Jenkinson, Garrett
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mathematical Physics (math-ph)
subject: Molecular Networks (q-bio.MN)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Complex networks, comprised of individual elements that interact with each other through reaction channels, are ubiquitous across many scientific and engineering disciplines. Examples include biochemical, pharmacokinetic, epidemiological, ecological, social, neural, and multi-agent networks. A common approach to modeling such networks is by a master equation that governs the dynamic evolution of the joint probability mass function of the underling population process and naturally leads to Markovian dynamics for such process. Due however to the nonlinear nature of most reactions, the computation and analysis of the resulting stochastic population dynamics is a difficult task. This review article provides a coherent and comprehensive coverage of recently developed approaches and methods to tackle this problem. After reviewing a general framework for modeling Markovian reaction networks and giving specific examples, the authors present numerical and computational techniques capable of evaluating or approximating the solution of the master equation, discuss a recently developed approach for studying the stationary behavior of Markovian reaction networks using a potential energy landscape perspective, and provide an introduction to the emerging theory of thermodynamic analysis of such networks. Three representative problems of opinion formation, transcription regulation, and neural network dynamics are used as illustrative examples.
description: 52 pages, 11 figures, for freely available MATLAB software, see http://www.cis.jhu.edu/~goutsias/CSS%20lab/software.html
A Ring-Handled Seal Jug from Old Bridge Street, Kingston Upon Thames
Creators: name: Nelson, Stephen
Publisher: name: Archaeology Data Service
Year: 2023

description: Medieval Ceramics: Journal of the Medieval Ceramics Research Group, 41, 83-88
description: This note records the presence of a medieval highly decorated jug of possibly unique design from Kingston upon Thames, London. It may be related to known medieval glazed grey and red ware wasters from the town. Chemical analysis (ICP-MS) carried out shows some affinity with at least one type of waster material from Kingston.
Effect of a preliminary test of homogeneity of stratum-specific odds ratios on their confidence intervals
Creators: name: Kabaila, Paul
name: Tissera, Dilshani
Publisher: name: arXiv
Year: 2011
Subjects: subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: Consider a case-control study in which the aim is to assess the effect of a factor on disease occurrence. We suppose that this factor is dichotomous. Also suppose that the data consists of two strata, each stratum summarized by a two-by-two table. A commonly-proposed two-stage analysis of this type of data is the following. We carry out a preliminary test of homogeneity of the stratum-specific odds ratios. If the null hypothesis of homogeneity is accepted then we find a confidence interval for the assumed common value (across strata) of the odds ratio. We examine the statistical properties of this two-stage analysis, based on the Woolf method, on confidence intervals constructed for the stratum-specific odds ratios, for large numbers of cases and controls for each stratum. We provide both a Monte Carlo simulation method and an elegant large-sample method for this examination. These methods are applied to obtain numerical results in the context of the large numbers of cases and controls for each stratum that arose in a real-life dataset. In this context, we find that the preliminary test of homogeneity of the stratum-specific odds ratios has a very harmful effect on the coverage probabilities of these confidence intervals.
description: The title has been shortened and the exposition has been improved
Evaluating the role of financial institutions in monetizing forest ecosystem values : existing arrangements and the viability of new arrangements
Creators: name: O'Loughnane, Guy
Publisher: name: University of British Columbia
Year: 2012

description: Forests contain a multitude of values, many of which are incorporated within the existing economic system, allowing us to create an economic value for forests. These values compete with alternative land uses to ascertain which is the most economically efficient. The continued process of forest land use conversion indicates that existing monetized forest values are insufficient to prevent global deforestation. Recognition of the importance of previously un-monetized forest values, such as forest carbon for climate regulation and species habitation for global biodiversity levels, has stimulated efforts to incorporate these values within the existing economic system. Previous efforts to ‘ring fence’ these assets by regulatory means has met with limited success. The creation of market based incentive systems to monetize these forest values has gained increasing support over the years as policy makers seek to build on earlier successes. Adaptations within and creation of new institutions has been required in order to establish these market based incentive systems. Ensuring that the correct institutional arrangements exist is vital for their institutional effectiveness. This is of particular importance with regards existing institutions as concerns abound about their governance, transparency and accountability arrangements. This thesis focuses on large scale publicly owned international banks and identifies various weaknesses in existing institutional arrangement and seeks to ascertain whether they have the adaptive capacity to address these shortfalls. The thesis also studies the creation of an entirely new institution, the International Forest Bank, as a viable alternative to adaptation processes. Despite the many shortfalls in existing institutional arrangements an International Forestry Bank was found to be too aspirational and of too great a scale. The research concludes that research into the creation of a smaller more regional International Forestry Bank would be warranted.
Two-color QCD via dimensional reduction
Creators: name: Zhang, Tian
name: Brauner, Tomáš
name: Kurkela, Aleksi
name: Vuorinen, Aleksi
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We study the thermodynamics of two-color QCD at high temperature and/or density using a dimensionally reduced superrenormalizable effective theory, formulated in terms of a coarse grained Wilson line. In the absence of quarks, the theory is required to respect the Z(2) center symmetry, while the effects of quarks of arbitrary masses and chemical potentials are introduced via soft Z(2) breaking operators. Perturbative matching of the effective theory parameters to the full theory is carried out explicitly, and it is argued how the new theory can be used to explore the phase diagram of two-color QCD.
description: 17 pages, 1 eps figure, jheppub style; v2: minor update, references added, published version
Double-Blind Parallel Design Pilot Study of Acetyl Levocarnitine in Patients with Alzheimer's Disease
Creators: name: Sano, Mary
name: Bell, Karen L.
name: Cote, Lucien J.
name: Dooneief, George
name: Lawton, Arlene
name: Legler, Louise
name: Marder, Karen
name: Naini, Ali B.
name: Stern, Yaakov
name: Mayeux, Richard Paul
Publisher: name: Columbia University
Year: 1992
Subjects: Neurology
Neuropsychological tests
Alzheimer's disease--Patients
Dementia--Treatment

description: Acetyl levocarnitine hydrochloride has been reported to retard dementia in patients with Alzheimer's disease. In a double-blind, parallel design, placebo-controlled pilot study of 30 mild to moderately demented patients with probable Alzheimer's disease, tests of memory, attention, language, visuospatial, and constructional abilities were administered, and the level of acetyl levocarnitine was measured in the cerebrospinal fluid. Patients were then randomly assigned to receive acetyl levocarnitine hydrochloride (2.5 g/d for 3 months followed by 3 g/d for 3 months) or placebo. After 6 months, the acetyl levocarnitine group demonstrated significantly less deterioration in timed cancellation tasks and Digit Span (forward) and a trend toward less deterioration in a timed verbal fluency task. No differences were found in any other neuropsychological test results. A subgroup with the lowest baseline scores, receiving acetyl levocarnitine, had significantly less deterioration on the verbal memory test and a significant increase in cerebrospinal fluid acetyl levocarnitine levels compared with those receiving placebo. These results suggest that acetyl levocarnitine may retard the deterioration in some cognitive areas in patients with Alzheimer's disease and stress the need for a larger study of this drug.
A study of topological insulators in three dimensions
Creators: name: Rosenberg, Gilad Amir
Publisher: name: University of British Columbia
Year: 2012

description: In this work we study four interesting effects in the field of topological insulators: the Witten effect, the Wormhole effect, topological Anderson insulators and the absence of bulk magnetic order in magnetically doped topological insulators. According to the Witten effect, a unit magnetic monopole placed inside a medium with non zero θ is predicted to bind a fractional electric charge. We conduct a first test of the Witten effect based on the recently established fact that the electromagnetic response of a topological insulator is given by the axion term θ(e²/2πh)B·E, and that θ=π for strong topological insulators. We establish the Wormhole effect, in which a strong topological insulator, with an infinitely thin solenoid of magnetic half flux quantum carries protected gapless and spin filtered one-dimensional fermionic modes, which represent a distinct bulk manifestation of the topologically non-trivial insulator. We demonstrate that not only are strong topological insulators robust to disorder but, remarkably, under certain conditions disorder can become fundamentally responsible for their existence. We show that disorder, when sufficiently strong, can transform an ordinary metal with strong spin-orbit coupling into a strong topological ‘Anderson’ insulator, a new topological phase of matter in three dimensions. Finally, we lay out the hypothesis that a temperature window exists in which the surface of magnetically doped topological insulators is magnetically ordered but the bulk is not. We present a simple and intuitive argument why this is so, and a mean-field calculation for two simple tight binding topological insulator models which shows that indeed a sizeable regime such as described above could exist. This indicates a possible physical explanation for the results seen in recent experiments.
Quantum limit for avian magnetoreception: How sensitive can a chemical compass be?
Creators: name: Cai, Jianming
name: Caruso, Filippo
name: Plenio, Martin B.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: The chemical compass model, based on radical pair reactions, is a fascinating idea to explain avian magnetoreception. At present, questions concerning the key ingredients responsible for the high sensitivity of a chemical compass and the possible role of quantum coherence and decoherence remain unsolved. Here, we investigate the optimized hyperfine coupling for a chemical compass in order to achieve the best magnetic field sensitivity. We show that its magnetic sensitivity limit can be further extended by simple quantum control and may benefit from additional decoherence. With this, we clearly demonstrate how quantum coherence can be exploited in the functioning of a chemical compass. The present results also provide new routes towards the design of a biomimetic weak magnetic field sensor.
description: 5 pages, 3 figures, comments are welcome,new references added