cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Provenance of mixed volcaniclastic-carbonaticlastic gravity-flow deposits: a case study from the Cretaceous of the southern Central Alborz (Iran)
Creators: name: Abbasian, Hedieh
name: Hosseini-Barzi, Mahboubeh
name: Sadeghi, Abbas
name: Amini, Abdolhossein
name: Garzanti, Eduardo
name: Ehteshami-Moinabadi, Mohsen
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Understanding the petrographic and geochemical characteristics of different tectonic settings is essential to improving traditional methods of identifying the provenance of palaeo-sedimentary environments. This research focuses on the K2b unit, which consists of mixed carbonate and volcanic lithic sandstones located in Iran with the age of the Turonian-Early Campanian period. Five sedimentary lithotypes with distinct petrographic and geochemical signatures were identified in the Turonian/Lower Campanian K2b unit, which consists of coarse-grained fan-delta strata. Carbonate and volcanic lithic fragments are the most characteristic components of mostly quartzo-lithic to felspatho-litho-quartzose sandstone layers, documenting a unidirectional paleocurrent pattern with the north-eastward direction. The original composition has undergone diagenesis, resulting in the precipitation of authigenic carbonates and depleting Rare Earth Elements (REE) except for Eu, which shows a positive anomaly. The K2b fan delta was situated on the margin of the proto-south Caspian back-arc basin, and the sediments were sourced from the undissected magmatic arc. The gravity flow deposits in the K2b unit were likely triggered by tectonic activity in the catchment area of the fan delta, leading to uplift and formation of relief associated with the regional Mosha Fault and, on a larger palaeogeographic scale, with subduction of the Arabian plate beneath the Iranian plate during Turonian-Early Campanian.
In eigener Sache: Es wird teurer
Creators: name: Busch, Saskia
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 24 Nr. 4 (2008): Bildet Banden! Kriminalität und Banden
Asienhaus-Bibliothek: Neueingänge
Creators: name: Redaktion, Die
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 24 Nr. 4 (2008): Bildet Banden! Kriminalität und Banden
Digitalt vejnet på vej
Creators: name: Larsen, Hans Jørgen
Publisher: name: Proceedings from the Annual Transport Conference at Aalborg University
Year: 2010

description: Vejdirektoratet har fået til opgave at gennemføre et forprojekt vedrørende etablering af et Digitalt Vejnet i Danmark. Det langsigtede mål er at tilvejebringe et landsdækkende, aktuelt og kvalitets- sikret vejnet, der er alment accepteret som datagrundlag for anvendelser, der bidrager til bedre miljø, fremkommelighed, trafiksikkerhed og services til transportbranche og trafikanter. Forprojek- tet skal levere beslutningsgrundlag for en eventuel landsdækkende udbredelse. Forprojektet planlægger allerede juni 2011 at udarbejde en indstilling om mulighederne for at etablere et landsdækkende vejnet og afsluttes ultimo 2011.
description: Proceedings from the Annual Transport Conference at Aalborg University, Vol. 1 No. 1 (2010): Proceedings from the Annual Transport Conference at Aalborg University
GPS realtidspilotprojekt – brug af GPS data til aktuel trafikinformation
Creators: name: Holm, Jan
Publisher: name: Proceedings from the Annual Transport Conference at Aalborg University
Year: 2010

description: Der beskrives et realtidssystem for hastighedsinformation baseret på GPS-data. Der gives demonstrationer af de implementerede systemer og de videre udbygningsplaner for GPS realtidsprojektet beskrives.
description: Proceedings from the Annual Transport Conference at Aalborg University, Vol. 1 No. 1 (2010): Proceedings from the Annual Transport Conference at Aalborg University
A methodology for inexpensive GPS data storage and analysis
Creators: name: Levin, Thomas
Publisher: name: Proceedings from the Annual Transport Conference at Aalborg University
Year: 2010

description: The increase in the use of tenders in Norwegian transportation research is forcing the research community to think in new ways. This paper looks into using open source software and consumer grade equipment for scientific purposes. The use of consumer grade data logger and open source hardware is a viable alternative. This paper documents the methods and the tools used for three research projects, 2 are close to finishing and one has just started. Vehicle speed and positional data was collected with inexpensive data loggers and data was stored and analyzed with open source tools. The tools proved to be more powerful, but they do not offer the same graphical user interfaces. The main way to analyze data is through the use of standard SQL. Both average speed calculations using a road network ana driver behavior analysis can be carried out we few lines of code for large amounts of data.
description: Proceedings from the Annual Transport Conference at Aalborg University, Vol. 1 No. 1 (2010): Proceedings from the Annual Transport Conference at Aalborg University
Vernissage und reichlich Information: »Politik und Kultur« zum Tag der offenen Tür im Asienhaus
Creators: name: Riehmer, Oda
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Zur Eröffnung vor zwölf Jahren lockte noch der Dalai Lama als Ehrengast ins Asienhaus. Heute herrschte beim Tag der Offenen Tür zeitweise so ein Andrang, dass sogar aufs Treppenhaus ausgewichen werden musste.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 24 Nr. 4 (2008): Bildet Banden! Kriminalität und Banden
The neuroprotective effects of Piracetam on cisplatin-induced cognitive decline
Creators: name: Elbeltagy, Maha
name: Khraisat, Bann
name: AlZoubi, Lujain
name: Hmoud, Leen
name: AlJeady, Ahmad
name: Yousef, Mohammed
name: Salman, Ahmed
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Medicine
Neuroscience
Pharmacology
Biotechnology
Mental Health

description: This work explores the effect of Cisplatin—a chemotherapeutic agent known to cause deterioration in cognitive function in cancer patients, and spatial memory in mice. It also investigates the potential neuroprotective effects of Piracetam, which is a nootropic drug recognized for improving cognitive ability. The study incorporates four groups of mice receiving varied medication regimens, with memory tested using the Novel Location Recognition (NLR) method. The findings from our study revealed that memory decline and a suppression of cellular proliferation were observed in adult male mice subjected to Cisplatin treatment; furthermore, a decline in antioxidant efficacy within the hippocampal dentate gyrus was evident. Moreover, analysis of treatment effects on the animals’ weight revealed that the Cisplatin and Piracetam group exhibited the most significant weight loss during drug administration. Despite the significant weight loss, the simultaneous use of Cisplatin and Piracetam demonstrated a notable improvement in memory and an augmentation of hippocampal proliferation and antioxidant effect. It is important to note that our study was hampered by budget limits, a lack of additional animals, and mice’s low tolerance for protracted treatment. Should the outcomes of Piracetam observed in this investigation be applicable to patients, it might offer a relatively straightforward approach to mitigate the cognitive impacts endured by cancer survivors following exposure to chemotherapy. Future research will be needed to study Piracetam’s effect on mice with brain cancer after Cisplatin treatment in order to extrapolate the results onto cancer patients.
Post-collisional calc alkaline-adakites from a metasomatized subcontinental lithospheric mantle: Sr-Nd isotopes and bulk-rock geochemistry of Miocene volcanic rocks from the Varzaghan area, NW Iran
Creators: name: Jahangiri, Ahmad
name: Farzaneh, Mostafa
name: Cousens, Brian
name: Moazzen, Mohssen
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Physiology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: The NW Iran is located at the western termination of the Alborz Mountain range and continuation of the Sanandaj-Sirjan magmatic-metamorphic zone at the NW. The volcanic rocks in the Varzaghan area are distributed over different compositional ranges from high-K basalt, andesite, dacite, and trachyandesite, dacite, to rhyolite with adakitic signatures. Chondrite-normalized REE diagrams show flat MREE and HREE patterns for calc-alkaline volcanic rocks and enrichment in LREE, indicating a garnet-free source. Adakitic rock sample chondrite-normalized REE patterns are relatively steep with significant enrichment in LREE and depletion in HREE, indicating a garnet-bearing source or garnet fractionation process. The arc trace element signatures, narrow range of initial87Sr/86Sr(i) = 0.70425–0.70487, different initial143Nd/144Nd(i) = 0.51264–0.51286 and the presence of adakitic rocks reveal that the volcanic rock sources were not the same and can be related to the partial melting of metasomatized mantle and lower continental crust sources. Slab break-off and upwelling of hot asthenosphere in a post-collisional tectonic regime resulted in the melting of the subcontinental lithosphere and lower continental crust which produced calc-alkaline-adakitic volcanic rocks in the Varzaghan area. The main petrological processes involved in the volcanic rocks petrogenesis were fractional crystallization and crustal assimilation.
Analytical approach to estimate SIF values for damaged steel plates repaired by CFRP laminate
Creators: name: Yu, Q. Q.
name: Zhao, X. L.
name: Xiao, Z. G.
name: Chen, T.
name: Gu, X. L.
Publisher: name: Swinburne
Year: 2024

description: Carbon fibre reinforced polymer (CFRP) composites have shown great promise in enhancing the fatigue life of metallic structures. Stress intensity factor (SIF) is a key parameter to analyze the progress of crack development using linear elastic fracture mechanics. Much research has been done focusing on the fatigue life and the SIF value of CFRP strengthened metallic elements. However, most of these studies relied on the experimental and numerical methods, which are expensive and time-consuming. This paper aims to develop an analytical approach to estimate the SIF value of CFRP repaired steel plate. The results from the analytical method compared well with these obtained using the finite element method, which demonstrated the analytical model was applicable in SIF prediction.
»Manchmal schämt man sich für seine Landsleute ...« Transnationale vietnamesische Verbrechensnetzwerke in Deutschland
Creators: name: Beuchling, Olaf
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Seit des Zusammenbruchs des Ostblocks und der deutschen Wiedervereinigung hat das organisierte Verbrechen aus Vietnam in Deutschland wie auch in anderen europäischen Staaten Fuß gefasst. In der öffentlichen Wahrnehmung ist der Handel mit unverzollten Zigaretten am stärksten präsent, doch stellt er nur eine Form der illegalen Aktivitäten vietnamesischer Migranten dar.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 24 Nr. 4 (2008): Bildet Banden! Kriminalität und Banden
Nachrichten
Creators: name: Reckordt, Michael
name: Bück, Philipp
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Nachrichten aus der Region.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 24 Nr. 4 (2008): Bildet Banden! Kriminalität und Banden
Klein-Manila in Mailand: Philippinische Migrant/innen in der lombardischen Domstadt
Creators: name: Agana, Rey
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Mailand wird normalerweise mit seinen touristischen Attraktionen - dem majestätischen Dom, dem Opernhaus und der Viktor-Emanuel- Galerie - in Verbindung gebracht. Erst während meiner letzten Reise nach Mailand entdeckte ich ein anderes Mailand als in meinem Reiseführer beschrieben: Ich fand Klein-Manila in Mailand.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 24 Nr. 4 (2008): Bildet Banden! Kriminalität und Banden
Testing the feasibility of a knowledge translation intervention designed to improve chiropractic care for adults with neck pain disorders: study protocol for a pilot cluster-randomized controlled trial
Creators: name: Dhopte, Prakash
name: Ahmed, Sara
name: Mayo, Nancy
name: French, Simon
name: Quon, Jeffrey A
name: Bussières, André
Publisher: name: BioMed Central
Year: 2017

description: Background: Neck pain in adults is common and a leading cause of physical disability. Recently, a guideline was developed for the management of non-specific neck pain (NSNP) with an aim to improve the quality of the delivery of chiropractic care. One key guideline recommendation is to undertake multimodal care for patients with NSNP. The aim of this pilot study is to determine the feasibility of implementing a multifaceted knowledge translation intervention by promoting the use of multimodal care by chiropractors managing patients with NSNP. Methods/design: The design is a cluster-randomized controlled pilot and feasibility trial. Chiropractors in private practice in Canada will be approached to participate in the study. Thirty consenting chiropractors will be randomized to receive either a theory-based educational intervention in the experimental group or simply a printed copy of the guideline in the control group. Each chiropractor will recruit five neck pain patients (a total of 150 patients) into the study. Development of the multifaceted intervention was informed by the results of a related qualitative study based on the Theoretical Domains Framework and consists of a series of three webinars, two online case scenarios, a self-management video on Brief Action Planning, and a printed copy of the practice guideline. Primary feasibility outcomes for both chiropractors and patients include rates of (1) recruitment, (2) retention, and (3) adherence to the intervention. A checklist of proxy measures embedded within patient encounter forms will be used to assess chiropractors’ compliance with guideline recommendations (e.g. exercise and self-care prescriptions) at study onset and at 3 months. Secondary outcomes include scores of behavioural constructs (level of knowledge and self-efficacy) for recommended multimodal care. Clinical outcomes include pain intensity and neck pain-specific disability. Analyses from this study will focus on generating point estimates and corresponding 95 % confidence intervals for parameters of a priori interest (recruitment, retention, adherence, pain intensity, Neck Disability Index). Discussion: Results of this study will inform the design of a larger cluster-randomized controlled trial aimed at evaluating the effectiveness of the theory-based tailored intervention and increasing the use of multimodal care by chiropractors managing patients with NSNP. Trial registration https://clinicaltrials.gov/ , NCT02483091
Trajectories of platelet indices and their association with mortality in the ICU—a longitudinal cohort study
Creators: name: Ali, Usman
name: Chopra, Mridula
name: Knight, Gavin
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: While thrombocytopenia’s link to mortality is known, the prognostic impact of longitudinal trajectories of platelet indices in combination with analysis of thrombocytopenia’s mediating role remains unexplored. This is the first study that addresses this significant gap by investigating the association between seven platelet indices trajectory subphenotypes and ICU mortality, considering thrombocytopenia’s mediating influence. Four hundred and twenty-one adult ICU patients were enrolled in this longitudinal cohort study. Three trajectories were identified for each platelet index, namely: descending, stable, and ascending, and using a regression, receiver-operating characteristic curve, and mediation analysis, their associations with 90-day mortality were evaluated with the mediating effect of thrombocytopenia. The findings were adjusted (prefixed ‘a’) for covariates. The heterogeneous trajectories significantly associated with 90-day mortality included: descending platelet count (PC) [aOR, 2.75 (CI, 1.56–4.85), p = 0.0005, aAUC, 0.783], descending plateletcrit (PCT) [aOR, 3.49 (CI, 1.88–6.46), p = 0.0001, aAUC, 0.802], ascending platelet distribution width (PDW) [aOR, 2.04 (CI, 1.13–3.71), p = 0.0188, aAUC, 0.776], and ascending percent-immature platelet fraction (%-IPF) [aOR, 2.25 (CI, 1.29–3.94), p = 0.0045, aAUC, 0.778], with 11.6% (p = 0.027), 12.0% (p = 0.019), 22.1% (p = 0.011), and 15.9% (p = 0.024) effects mediated by thrombocytopenia, respectively. In contrast, ascending mean platelet volume (MPV) was significantly and independently associated with mortality [aOR, 3.04 (CI, 1.45–6.39), p = 0.0033, aAUC, 0.781], without the effect mediated by thrombocytopenia (p = 0.056). The trajectories of platelet-large cell ratio (P-LCR) and absolute-immature platelet count (A-IPF) were not significantly associated with the risk of mortality (p > 0.05). This study demonstrated that descending PC and PCT and ascending PDW and %-IPF, mediated by thrombocytopenia, and ascending MPV, without mediation by thrombocytopenia, are useful longitudinal trajectories for predicting 90-day mortality in the ICU.
Investigating Electrophysiological Changes in Blood Cells Using Dielectrophoresis
Creators: name: KRUCHEK, EMILY JANE
Publisher: name: University of Surrey
Year: 2022

description: "The electrophysiological variation of RBCs and platelets is intriguing, as both are anucleate and lack traditional cellular apparatus; their behaviour is driven by the ion channels within the membrane. Assessment and characterisation of the electrophysiological rhythms of red blood cells (RBCs), and the observation of similar rhythms in platelets, is potentially of importance due to the temporal incidence of many diseases associated with these cell types. RBCs and platelets were examined using various methods including dielectrophoresis, flow cytometry, and zeta potential to assess for rhythmic properties.
description: This work demonstrates that casein kinase is involved in RBC electrophysiological rhythms. Inhibition of casein kinase in RBCs altered the observed rhythm, revealing its involvement in both RBC electrophysiological rhythms and temperature compensation. The possible roles of intrinsic and extrinsic factors in RBC electrophysiological rhythms were examined. Levels of haemoglobin, ionic abundance, and passive electrophysiology were found to show time of day variation. Furthermore, zeta potential was used as a novel method to examine rhythmic electrophysiology.
description: This thesis provides the first evidence of the presence of electrophysiological rhythms in platelets. Platelet electrophysiology was assessed in: platelet rich plasma immediately after venepuncture, stored platelet rich plasma, and stored resuspended platelets. Each condition exhibited a rhythm of differing period, suggesting the platelet entrainment mechanism involves at least three components: an intrinsic platelet component, entraining plasma component, and endogenous circulation component. Furthermore, activated platelets showed altered rhythms in each condition, suggesting the presence of an additional clock, functioning on platelet activation. The electrophysiological rhythm of a platelet precursor cell line was examined (in the assessment of the origin of platelet rhythms) and was found to be different to that of platelets."
Brüchiger Frieden im Süden der Philippinen: Durch die Nichtunterzeichnung eines Abkommens sind die Friedensgespräche erneut kollabiert
Creators: name: Bück, Philipp
name: Grigat, Sonja
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Der Friedensprozess in Mindanao liegt in Folge der Nichtunterzeichnung eines sogenannten Memorandum of Agreement on Ancestral Domain (MOA-AD) brach und es besteht die akute Gefahr einer Eskalation von Kampfhandlungen. Der Oberste Gerichtshof der Philippinen hatte im August 2008 die Unterzeichnung des Abkommens mit einer einstweiligen Verfügung verhindert; mittlerweile erklärte er das MOA-AD für verfassungswidrig.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 24 Nr. 4 (2008): Bildet Banden! Kriminalität und Banden
»Schwesternbande«: Mädchengangs in Davao City
Creators: name: Anson, Ryan
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Auf dem Maa-Friedhof von Davao City versammelt sich eine Bande von Mädchen, um einer der ihren zu gedenken. Es ist der 28. September 2003, der zweite Geburtstag der Warshock Gang. Nur wenige der traurigen Jugendlichen haben etwas zu sagen. Keine hat einen Grund zum Feiern.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 24 Nr. 4 (2008): Bildet Banden! Kriminalität und Banden
Circadian rhythm and the influence of light on parameters related to calcium metabolism in stroke patients admitted for rehabilitation
Creators: name: Qadir, Shanga Hassan
name: Iversen, Helle Klingenberg
name: Jørgensen, Niklas Rye
name: Jennum, Poul Jørgen
name: Sennels, Henriette Pia
name: West, Anders Sode
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Mental Health

description: Hospitalized stroke patients are at high risk of developing circadian disruption due to lack of natural sunlight. This may affect the circadian rhythm of the calcium metabolism. This study is a secondary explorative analysis from a Randomized Controlled Trial. Acute stroke patients requiring a minimum of two weeks of rehabilitation were randomized to an Intervention unit (IU) equipped with naturalistic light or a Control unit (CU) with standard indoor lighting. Blood was drawn across 24 h at inclusion and discharge in 45 patients, 25 from the IU and 20 from the CU. Calcium showed significant rhythmicity at inclusion and discharge in both groups. Alkaline phosphatase, parathyroid hormone (PTH), and Vitamin D exhibited no significant rhythmicity at inclusion or discharge in either group while phosphate exhibited rhythmicity at discharge in the CU. PTH levels were elevated in the CU group compared to the IU group at time of discharge. Of the measured parameters, only calcium exhibited circadian rhythmicity after stroke. Naturalistic light did not have any influence on the rhythmicity, indicating that light may not be the main circadian regulator of the circadian oscillations that regulate calcium metabolism. PTH seems to be decreased by naturalistic light.
Wenn die »Alarmglocken« schrillen: Mindanaos Mafia verfügt über beste Beziehungen in die philippinische Politik
Creators: name: Torres Jr., Jose
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Die Kuratong Baleleng (»Alarmglocke«) begann als antikommunistische Bürgerwehr und wurde mit der Zeit zu einem breit gefächerten Syndikat für Kidnapping, Schmuggel und Erpressung, mit engen Verbindungen zu Offiziellen in Nordwest-Mindanao und anderswo in den Philippinen.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 24 Nr. 4 (2008): Bildet Banden! Kriminalität und Banden
Design, Synthesis and Biological Evaluation of Azasugar Nucleoside Mimics for Glycosylase Inhibition
Creators: name: Hiles, Jacob
Publisher: name: University of Surrey
Year: 2024

description: In mice, the action of the DNA repair enzyme alkyladenine DNA glycosylase (AAG) has been found to cause cell death in different organs, including the retina, spleen, thymus, and cerebellum, in response to alkylation-induced DNA damage. Additionally, AAG has been associated with damage resulting from ischaemia/reperfusion (I/R) events in the liver, brain, and kidney. Consequently, there is a need to develop small molecule inhibitors of AAG to further investigate the biological mechanisms of cellular damage caused by AAG, as well as for potential drug leads for retinal degeneration, I/R-related tissue damage, or as protective agents for patients undergoing alkylative chemotherapy who display increased AAG activity. Such inhibitors could also serve the opposite effect by acting as an alkylating agent (TMZ) sensitiser in paediatric glioblastoma (GBM).

description:

description: Although two DNA oligomers containing etheno-cytidine or an abasic pyrrolidine have been found to effectively inhibit AAG in vitro, they are not viable drug leads in vivo due to their size and charged nature, which makes them poorly permeable to membranes and susceptible to degradation by nucleases. However, these oligomers' motifs and the examination of the enzyme active site led to the conception of two small drug-like pyrrolidine-based inhibitor candidates, 2-(hydroxymethyl)pyrrolidines and 4-(hydroxymethyl)pyrrolidines, which could be developed as drug leads. A hit compound discovered by previous research in the group served as the starting point for further optimisation.

description:

description: This study optimised the synthetic routes to these inhibitor candidates and developed a bioassay to evaluate their enzymatic activity, including the synthesis of abasic site binding probes and optimisation of a previously developed bound fluorophore assay. Although the synthetic route to the 2-(hydroxymethyl)pyrrolidines failed during the attachment of DNA base-mimicking aryl groups, three 4-(hydroxymethyl)pyrrolidines nucleoside mimetics were successfully synthesised, bearing bicyclic heteroaromatic groups to represent a DNA base. All inhibitor candidates were assessed for their bioactivities but showed no inhibitory activity, including the previously discovered hit compound when re-synthesised. Investigation into the cause of the hit compounds failure was also undertaken.

description:

description: Overall, this study represents progress in developing AAG inhibitors and provides a basis for further research into the biological effects of AAG and its potential as a drug target for various diseases.
AWA today and how it got here
Creators: name: Given, Jock
Publisher: name: Swinburne
Year: 2024

description: AWA today is an information technology services business. Its headquarters arc at Homebush West in Sydney and it has offices in the other four mainland state capitals and Newcastle. According to a director and large shareholder, John Dougall, the business turns over around $40 million in annual revenue, employs about 300 full-time staff and 700 agents in rural, regional and remote Australia, and averages about 1,000 field visits to customers each day. Dougall led a management buy-out of this business from Tabcorp in 2004. Tabcorp acquired it the previous year when it took over Jupiters, owner of AWA since 2000. The casino operator had acquired AWA for the gaming business built over the previous decade.
Die Herrschaft des (Ampatuan-)Klans in Maguindanao: Waffen und politische Seilschaften nach ganz oben sichern die Vorherrschaft der Familiendynastie
Creators: name: Jimeno, Jaileen F.
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Lautes Hupen eilt einem Konvoi von Geländewagen voraus. »Du musst ihnen ausweichen, andernfalls beschädigen sie deinen Wagen. Und dann lassen sie es schließlich so aussehen, als wärest du einer ihrer Feinde«, erklärt ein älterer Mann, der sich die Szenerie vom Straßenrand anschaut. Auf die Frage, wessen Konvoi aus schwarzen Wagen mit getönten Fensterscheiben da gerade vorbeiflitze, antwortet der Mann ohne Zögern: »Das ist der Gouverneur. So sehen dessen Fahrzeuge aus.«
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 24 Nr. 4 (2008): Bildet Banden! Kriminalität und Banden
title: Transcription de l'acte de la donation entre vifs
Creators: name: Trouvé, William
name: Trouvé, William
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2025
Subjects: subject: fondation
subject: bibliothèque
subject: règlement
subject: horaires

description: Acte de donation entre vifs, passé entre Nicolas Goutard et les Cordeliers de Vire (21 septembre 1731).
description: Source: Médiathèque de Vire Normandie, ms. A 204
title: Acte de donation entre vifs
Creators: name: Goutard, Nicolas
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2025
Subjects: subject: fondation
subject: bibliothèque
subject: règlement
subject: horaires

description: Acte de donation entre vifs, passé entre Nicolas Goutard et les Cordeliers de Vire (21 septembre 1731).
description: Source: Médiathèque de Vire Normandie
The relationship between hemolysis and I-index: investigating its use as a screening test in hyperbilirubinemia
Creators: name: Yavuz, Hatice Bozkurt
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Medicine
Cell Biology
Molecular Biology
Biological Sciences not elsewhere classified
Science Policy
Hematology

description: Hemolysis (H-index) and icteric indexes (I-index) are widely used in clinical laboratories to control interferences. Since I-index correlates with bilirubin, it can aid in deciding whether to analyze bilirubin levels. The study aims to evaluate I-index use for this purpose, considering H-index interference on I-index. This retrospective study included H-index, I-index and total bilirubin results, all analyzed using the Mindray BS800M. Total bilirubin was analyzed using the Vanadate oxidase method. Patients were categorized according to their H-index values in multiples of 0.5. Group-0 had the lowest hemolysis (<0.5 g/L), and Group-10 had the highest hemolysis (>5 g/L), with a total of 11 groups. ROC analysis determined optimal I-index cut-offs to differentiate normal and abnormal bilirubin levels, calculating PPV, NPV, specificity and sensitivity. Indexes of 55,306 patients and total bilirubin results of 26,781 patients were evaluated. There was no significant difference between the groups in pairwise comparison for bilirubin results but significant differences were observed in I-index values. When the I-index values were examined, there were significant differences between Group 0,1,2,3,4, and all groups from 0 to 10 (p < 0.001). As hemolysis increased, the I-index cutoff values decreased. While the cut-off values for Group-0 and Group-4 ranged from 16.70 to 14.15 μmol/L, in Group-5 (hemolysis 2.5-3 g/L), the cut-off was 6.50 μmol/L, in Group-6 and Group-7, it was −2.35 μmol/L. In Group-10, this value dropped to −42.55 μmol/L. Our findings suggest using the I-index to spot hyperbilirubinemia and save on testing. However, different cut-off values should be calculated according to the hemolysis value.
The role of diet and gut microbiota in lipid metabolism: implications for health outcomes using a mouse model.
Creators: name: Ampong, Isaac
Publisher: name: University of Surrey
Year: 2020

description: The prevalence of non-Alcoholic Fatty Liver Disease (NAFLD) has now reached epidemic proportions, but the role of gene-lifestyle interactions in its pathogenesis remains poorly understood. While evidence for an inverse association between odd-chain length fatty acids (OCFA) and cardiometabolic diseases, suggests a possible link between OCFAs and NAFLD, little is known about the impact of diet, gut microbiota and peroxisomal biogenesis on the metabolism of OCFAs. We hypothesized that suboptimal diet, altered gut microbiota and peroxisomal biogenesis could promote the development of NAFLD by impairing the metabolism of OCFAs. This thesis aimed to understand the effect of dietary fat/protein on the genetic and metabolic regulation of lipids and OCFAs in relation to NAFLD, using a high fat diet (HFD) model, well established in the literature for inducing obesity and insulin resistance in mice within 4 weeks, and a low protein diet (LPD) model, known to promote NAFLD. Under specific pathogen free or normal husbandry conditions, a HFD reduced serum OCFA in mice after 4 and 12 weeks of feeding, and down-regulated the activity of several key enzymes in fatty acid metabolism (desaturases, lyase, elongase). Liver histology also showed deposition of lipid droplets and higher expression of peroxin 14 protein in HFD fed mice (Chapter 3). The characterisation of gut microbiota revealed an alteration in propionate-producing bacteria, Lachnospiraceae and Clostridiales, in HFD fed mice (Chapter 4). Mice fed with carbohydrate rich-LPD for 7 weeks resulted in lower levels of serum OCFA, increased CD36 mRNA and peroxin 14 expressions. However, OCFA did not change in the reduced and quality carbohydrate-LPD after 8 weeks (Chapter 5). In conclusion, these findings provide evidence that HFD and carbohydrate rich-LPD reduced OCFA via changes in gut microbiota and peroxisomal biogenesis in the liver and increases our understanding of how suboptimal diets contributes to NAFLD.
Verbrechen lohnt sich doch: Syndikate in den Philippinen streichen Unmassen an Geld ein
Creators: name: Coronel, Sheila S.
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Wer auch immer behauptet Verbrechen lohne sich nicht, hat sicherlich unrecht. Organisiertes Verbrechen ist in den Philippinen eine Multimilliarden-Peso Industrie. Die Einnahmen entsprechen nach vorsichtigen Schätzungen zehn bis 20 Prozent des philippinischen Bruttoinlandsproduktes oder 300 bis 600 Milliarden Pesos pro Jahr.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 24 Nr. 4 (2008): Bildet Banden! Kriminalität und Banden
Responses to welfare-to-work reforms and superannuation issues for sole mothers
Creators: name: Wyatt, Sandra Lorraine
Publisher: name: Swinburne
Year: 2024

description: The aim of my exploratory study was to provide an explanation of how sole mothers have coped with the impact of the Welfare-to-Work Reforms introduced in the Australian Budget of 2005, as well as how they might plan for their future. I employed a mixed-methods approach, and using the principles and processes of a grounded theory approach the inductively derived theory of finessing emerged. This parsimonious theory of finessing is a unique conceptualisation which illustrates and conceptualises the strategies invoked by sole mothers when dealing with both these short term and long term issues. I trust that my study can provide sole mothers with some strategies to assist them to cope. It may also provide a useful tool to frame future policy implementations, as it provides the individual, or micro, perspective of how policies impact at the grass-roots level.
Nachrichten
Creators: name: Groß, Stefanie
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Nachrichten aus der Region.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 24 Nr. 4 (2008): Bildet Banden! Kriminalität und Banden
Nachrichten
Creators: name: Arnez, Monika
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Nachrichten aus der Region.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 24 Nr. 4 (2008): Bildet Banden! Kriminalität und Banden
Continuum elasticity models for tissue growth and mechanotransduction.
Creators: name: Littlejohns, Euan
Publisher: name: University of Surrey
Year: 2020
Subjects: Mechanotransduction
Tissue growth
Mechanics

description: We here consider modelling tissue growth and mechanotransduction, utilising a continuum approach based on the theory of elasticity. Our models are valid for both unhealthy and healthy tissues and assume a spherical symmetry is present. In principal, there are a number of tissue types which can be modelled using our framework, however, we choose to focus on three main tissue paradigms; epithelial cysts, ovarian follicles and avascular tumour spheroids, which all share common geometric features of a central core, surrounded by a proliferating rim of cells. In all cases, the tissues are embedded in a constraining outer gel. We show that growth within the tissue leads to the build-up of internal stress, and we find potential mechanotransductive mechanisms occurring as a result of this growth. These mechanisms are deemed switching points and we show that they can occur both as a result of the internal stress and of the associated strains. We also find that, for systems with a deformable central core, this core can expand and shrink passively as a result of growth within the surrounding material in parameter regimes that we identify. We also relax the assumption that the inner core is non-growing and consider that both phases of the tissue undergo growth. This leads to a competition of growth and we show that switching still occurs, but is now dependent upon the growth in both regions. This is considered specifically in the case of ovarian follicles, where we further observe that the cuboidalisation of cells can be produced as a consequence of the mechanics within the system. We next consider the addition of the effect of contractility upon the linear model using two techniques of implementation. The necessity of the use of nonlinear elasticity is then tested, from which we show that for most parameters within the realms of soft biological tissues, the linear approximation to the nonlinear model is of a sufficient likeness to warrant the use of the linear scheme. We find that the ratio of the Young's modulus of the tissue and the surrounding medium is key in determining the effectiveness of the linear model. These studies consistently highlight the importance of the mechanical properties of the tissue and surrounding extracellular matrix, specifically stressing the significance of the Young's modulus upon tissue growth dynamics.
Die Stimmen der Frauen
Creators: name: Prüller, Vanessa
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Buchbesprechung von: Monika Amez & Edwin Wieringa (Hrsg.), Duft der Asche. Literarische Stimmen indonesischer Frauen. Horlemann Verlag, 2008. ISBN 978-3895022692.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 24 Nr. 4 (2008): Bildet Banden! Kriminalität und Banden
OML-Highway – en ny brugervenlig GIS-baseret luftkvalitetsmodel for motorveje, landeveje og andre veje i åbent terræn
Creators: name: Jensen, Steen Solvang
name: Ketzel, Matthias
name: Becker, Thomas
name: Løfstrøm, Per
name: Olesen, Helge Rørdam
name: Lorentz, Helmut
name: Michelsen, Lene Nøhr
name: Fryd, Jacob
Publisher: name: Proceedings from the Annual Transport Conference at Aalborg University
Year: 2010

description: Der er udviklet en ny GIS-baseret brugervenlig brugerflade til luftkvalitetsmodellen OML-Highway, som muliggør beregning af luftkvaliteten langs motorveje, landeveje og øvrige veje i åbent terræn. Endvidere er identificeret potentielle anvendelsesmuligheder af OML-Highway, og illustreret to konkrete eksempler på anvendelser: kortlægning langs en motorvej og effekten af en støjskærm.
description: Proceedings from the Annual Transport Conference at Aalborg University, Vol. 1 No. 1 (2010): Proceedings from the Annual Transport Conference at Aalborg University
Geschenk für religiöse Hardliner: Zum Antipornografie-Gesetz
Creators: name: Keller, Anett
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Der 30. Oktober 2008 wird als immenser Rückschritt in die Geschichte der jungen Demokratie Indonesiens eingehen. Gegen den intensiven Widerstand breiter Teile der Bevölkerung boxte das Parlament ein Antipornografie-Gesetz durch.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 24 Nr. 4 (2008): Bildet Banden! Kriminalität und Banden
Udvikling af et SP-eksperiment vedrørende efterspørgslen efter elbiler
Creators: name: Jensen, Anders Fjendbo
Publisher: name: Proceedings from the Annual Transport Conference at Aalborg University
Year: 2010

description: Dette paper beskriver udviklingen af en internetapplikation, som kan benyttes til at indsamle viden om forbrugernes præferencer for elbiler. Dataindsamlingen baseres på Stated Preference metoder, hvor hver respondent i undersøgelsen bliver bedt om at foretage en række hypotetiske valg imellem en elbil og en benzin- eller dieselbil. De enkelte scenarier bliver opbygget ved systematisk at variere et antal attributter vha. eksperimentelt design. Et stort antal af disse attributter varierer ud fra referenceværdier, som er skræddersyet til den enkelte respondent ud fra indledende besvarelser i interviewet. På denne måde kommer de opbyggede scenarier til at fremstå så realistiske, som muligt for den enkelte respondent. Udover en række attributter, der beskriver bilernes pris og egenskaber, er der inkluderet et antal attributter, der beskriver tilgængeligheden til forskellige opladningsmuligheder for elbiler. Baseret på en indledende indsamling af data, er der estimeret en Logit model. Resultaterne indikerer, at især lavere købpris, lavere marginale omkostninger, større rækkevidde og større tophastighed er vigtige i forbindelse bilvalget. Forbrugerens præferencer for elbiler kan derudover fremmes med længere batterilevetid, flere lynladestationer, ligesom det er vigtigt, at der er en tilgængelig laderstander tæt på hjemmet til opladning af elbilen om natten. Resultaterne indikerer desuden, at kvinder har større præferencer for elbiler end mænd. Det var ikke muligt at få signifikante parametre på attributterne for CO2-udledning samt for mulighed for opladning på arbejdsplads.
description: Proceedings from the Annual Transport Conference at Aalborg University, Vol. 1 No. 1 (2010): Proceedings from the Annual Transport Conference at Aalborg University
Dental Disease Detection with Crowdsourced Radiograph Annotations
Creators: name: Yin, Ruoqing
Publisher: name: University of Surrey
Year: 2023

description: The interpretation of dental radiographs often varies due to the subjective nature of the
description: diagnostic process, leading to inconsistencies in diagnoses and treatments. To address
description: this challenge, this research focuses on the development of an advanced model for dental
description: disease detection. This model, utilising crowdsourced annotations from radiographic
description: images, aims to assist dental practitioners in identifying basic dental abnormalities from
description: radiographs.

description:

description: Introducing Crowd-YOLO, an innovative adaptation of the object detection model
description: YOLOv3, this approach incorporates Bayesian classifier combination to effectively measure
description: data uncertainty and enhance accuracy. Crowd-YOLO distinguishes itself by extracting
description: reliable information from the majority of non-expert annotations and very
description: limited annotation from the expert, employing a confusion matrix to evaluate each annotator’s
description: capability in diagnosing various diseases. This methodology presents a novel
description: approach to mitigating discrepancies among different annotators.
Fürchtet Euch nicht! Das Pornographie-Gesetz ist verabschiedet
Creators: name: Großmann, Kristina
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Kristina Großmann interviewte zum soeben verabschiedeten und heftig umstrittenen Pornographie-Gesetz Dewi Candraningrum, Dozentin an der Universität Muhammadiyah in Surakarta und Mitglied der Organisation Jurnal Perempuan, für die südostasien.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 24 Nr. 4 (2008): Bildet Banden! Kriminalität und Banden
Forsøgsordning med biodiesel
Creators: name: Frees, Niels
Publisher: name: Proceedings from the Annual Transport Conference at Aalborg University
Year: 2010

description: Færdselsstyrelsen fik i starten af 2007 bevilliget 60 mio. kr. til en forsøgsordning med anvendelse af biodiesel i køretøjer hvori afgrænsede flåder af køretøjer skulle anvende en vis mængde biodiesel under afprøvning af brændstofferne. Forsyning med biodiesel skulle også undersøges. I foråret 2008 iværksat fire projekter, der er afsluttet i foråret 2010: • Forsøg med forsyning (B5Next) med 5 pct. biodiesel til den almindelige forbruger fra ca. 70 tankstationer i Århus kommune – ved DAKA Biodiesel sammen med Region Midtjylland. Forsøget omfatter også bybusser, der tanker hjemme. • Forsøg med 10 – 30 pct. blandinger af animalsk biodiesel (AFME) i busser, lastbiler og varebiler– ved Teknologisk Institut • Forsøg med 10 – 100 pct. blandinger af vegetabilsk biodiesel (RME) i busser og lastbiler– ved Niras Rådgivende Ingeniører. • Forsøg med ren koldpresset rapsolie (KRO) i busser, lastbiler og varebiler – ved Odense kommune. Forsøget med forsyning har udført arbejdet med opblanding og lagring af en 5 % blanding af animalsk biodiesel, der opfylder standarden EN590 for salg fra tankstationer. Udfordringerne har især været kuldestabilitet om vinteren, men også opfyldelse af standardens massefyldekrav. En anden udfordring har været at kontrollere biologisk vækst i biodieselblandingen. Endelig er der gjort erfaring med myndighedsgodkendelse af blandings- og lagertanke. Erfaringerne er anvendt i Energistyrelsens udrulning af den tvungne iblanding af biodiesel, der implementeres fra 2010 – 2012. Erfaringerne med 10 – 30 % blandinger af animalsk biodiesel og 10 – 100 % vegetabilsk biodiesel viser, at køretøjerne kører problemfrit hvis man træffer enkelte forholdsregler omkring olieskift, evt. udskiftning af brændstofslanger mv. på nogle typer køretøjer samt vinterberedskab ved hård frost ved at gå ned i blandingsforhold afhængigt af frostgraderne for især den animalske biodiesel. Bilerne forurener som helhed ikke mere end med almindelig dieselolie, men forureningsmønsteret kan ændres noget (mere NOx, mindre CO og HC, partikeludslippets karakteristik kan ændres). Kørsel på koldpresset rapsolie kræver en mindre ombygning af køretøjets brændstoftilførsel da rapsolien er mere tyktflydende end dieselolie. Bilerne må derfor enten køre på almindelig diesel indtil motoren er driftsvarm og herefter slå om på rapsolie, eller rapsolien må forvarmes. Der har været forskellige udfordringer med ombygningsudstyret og dets funktion. Ved et driftsmønster med megen tomgangskørsel skal motorolien skiftes hyppigt hvis risiko for motorskader skal undgås. Forureningsmønsteret viser nogenlunde samme billede som for biodiesel.
description: Proceedings from the Annual Transport Conference at Aalborg University, Vol. 1 No. 1 (2010): Proceedings from the Annual Transport Conference at Aalborg University