A connectome and analysis of the adult Drosophila central brain
Creators: name: Scheffer, Louis K
name: Xu, C Shan
name: Januszewski, Michal
name: Lu, Zhiyuan
name: Takemura, Shin-Ya
name: Hayworth, Kenneth J
name: Huang, Gary B
name: Shinomiya, Kazunori
name: Maitlin-Shepard, Jeremy
name: Berg, Stuart
name: Clements, Jody
name: Hubbard, Philip M
name: Katz, William T
name: Umayam, Lowell
name: Zhao, Ting
name: Ackerman, David
name: Blakely, Tim
name: Bogovic, John
name: Dolafi, Tom
name: Kainmueller, Dagmar
name: Kawase, Takashi
name: Khairy, Khaled A
name: Leavitt, Laramie
name: Li, Peter H
name: Lindsey, Larry
name: Neubarth, Nicole
name: Olbris, Donald J
name: Otsuna, Hideo
name: Trautman, Eric T
name: Ito, Masayoshi
name: Bates, Alexander S
name: Goldammer, Jens
name: Wolff, Tanya
name: Svirskas, Robert
name: Schlegel, Philipp
name: Neace, Erika
name: Knecht, Christopher J
name: Alvarado, Chelsea X
name: Bailey, Dennis A
name: Ballinger, Samantha
name: Borycz, Jolanta A
name: Canino, Brandon S
name: Cheatham, Natasha
name: Cook, Michael
name: Dreher, Marisa
name: Duclos, Octave
name: Eubanks, Bryon
name: Fairbanks, Kelli
name: Finley, Samantha
name: Forknall, Nora
name: Francis, Audrey
name: Hopkins, Gary Patrick
name: Joyce, Emily M
name: Kim, SungJin
name: Kirk, Nicole A
name: Kovalyak, Julie
name: Lauchie, Shirley A
name: Lohff, Alanna
name: Maldonado, Charli
name: Manley, Emily A
name: McLin, Sari
name: Mooney, Caroline
name: Ndama, Miatta
name: Ogundeyi, Omotara
name: Okeoma, Nneoma
name: Ordish, Christopher
name: Padilla, Nicholas
name: Patrick, Christopher M
name: Paterson, Tyler
name: Phillips, Elliott E
name: Phillips, Emily M
name: Rampally, Neha
name: Ribeiro, Caitlin
name: Robertson, Madelaine K
name: Rymer, Jon Thomson
name: Ryan, Sean M
name: Sammons, Megan
name: Scott, Anne K
name: Scott, Ashley L
name: Shinomiya, Aya
name: Smith, Claire
name: Smith, Kelsey
name: Smith, Natalie L
name: Sobeski, Margaret A
name: Suleiman, Alia
name: Swift, Jackie
name: Takemura, Satoko
name: Talebi, Iris
name: Tarnogorska, Dorota
name: Tenshaw, Emily
name: Tokhi, Temour
name: Walsh, John J
name: Yang, Tansy
name: Horne, Jane Anne
name: Li, Feng
name: Parekh, Ruchi
name: Rivlin, Patricia K
name: Jayaraman, Vivek
name: Costa, Marta
name: Jefferis, Gregory SXE
name: Ito, Kei
name: Saalfeld, Stephan
name: George, Reed
name: Meinertzhagen, Ian A
name: Rubin, Gerald M
name: Hess, Harald F
name: Jain, Viren
name: Plaza, Stephen M
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Research Article
Computational and Systems Biology
Neuroscience
connectome
brain regions
cell types
graph properties
connectome reconstuction methods
synapse detecton
D. melanogaster

description: The neural circuits responsible for animal behavior remain largely unknown. We summarize new methods and present the circuitry of a large fraction of the brain of the fruit fly Drosophila melanogaster. Improved methods include new procedures to prepare, image, align, segment, find synapses in, and proofread such large data sets. We define cell types, refine computational compartments, and provide an exhaustive atlas of cell examples and types, many of them novel. We provide detailed circuits consisting of neurons and their chemical synapses for most of the central brain. We make the data public and simplify access, reducing the effort needed to answer circuit questions, and provide procedures linking the neurons defined by our analysis with genetic reagents. Biologically, we examine distributions of connection strengths, neural motifs on different scales, electrical consequences of compartmentalization, and evidence that maximizing packing density is an important criterion in the evolution of the fly’s brain.