cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Hur reduces radiation-induced DNA damage by enhancing expression of ARID1A
Creators: name: Gorospe, M.
name: Andrade, D.
name: Herman, T.
name: Aube, J.
name: De, S.
name: Mehta, M.
name: Babu, A.
name: Oh, S.
name: Zhao, Y.D.
name: Husain, S.
name: Xu, L.
name: Griffith, J.
name: Munshi, A.
name: Corbin, J.
name: Chen, A.
name: Roy, S.
name: Ramesh, R.
name: Janknecht, R.
Publisher: name: MDPI AG
Year: 2019

description: Tumor suppressor ARID1A, a subunit of the chromatin remodeling complex SWI/SNF, regulates cell cycle progression, interacts with the tumor suppressor TP53, and prevents genomic instability. In addition, ARID1A has been shown to foster resistance to cancer therapy. By promoting non-homologous end joining (NHEJ), ARID1A enhances DNA repair. Consequently, ARID1A has been proposed as a promising therapeutic target to sensitize cancer cells to chemotherapy and radiation. Here, we report that ARID1A is regulated by human antigen R (HuR), an RNA-binding protein that is highly expressed in a wide range of cancers and enables resistance to chemotherapy and radiation. Our results indicate that HuR binds ARID1A mRNA, thereby increasing its stability in breast cancer cells. We further find that ARID1A expression suppresses the accumulation of DNA double-strand breaks (DSBs) caused by radiation and can rescue the loss of radioresistance triggered by HuR inhibition, suggesting that ARID1A plays an important role in HuR-driven resistance to radiation. Taken together, our work shows that HuR and ARID1A form an important regulatory axis in radiation resistance that can be targeted to improve radiotherapy in breast cancer patients.
Additional file 2 of Opening the door to university health research: recommendations for increasing accessibility for individuals with intellectual disability
Creators: name: St. John, Brittany M.
name: Hickey, Emily
name: Kastern, Edward
name: Russell, Chad
name: Russell, Tina
name: Mathy, Ashley
name: Peterson, Brogan
name: Wigington, Don
name: Pellien, Casey
name: Caudill, Allison
name: Hladik, Libby
name: Ausderau, Karla K.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Science Policy

description: Additional file 2.
Additional file 1 of The validity of astrological predictions on marriage and divorce: a longitudinal analysis of Swedish register data
Creators: name: Helgertz, Jonas
name: Scott, Kirk
Publisher: name: figshare
Year: 2020
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1: Table A1: Variable means, analytical sample. Table A2: Cox proportional hazards regression hazard ratios. Complete models, with all sociodemographic characteristic. Table A3: Cox proportional hazards estimates. Hazard ratios. Sensitivity analysis adjusting for asymmetries in original sources. Table A4: Cox proportional hazards estimates. Hazard ratios. Sensitivity analysis on sample excluding cusp birth index individuals and spouse.
The impact of Covid-19 on the profitability of Islamic banks: Evidence from Islamic banks based in Bahrain
Creators: name: Alsaboodi, Mohamed
Publisher: name: American University of Bahrain
Year: 2023
Subjects: classificationCode: 3502
subject: Banking, finance and investment
classificationCode: 350204
subject: Financial institutions (incl. banking)

description: The pandemic has presented difficult challenges in the banking sector worldwide, in which the sector had to suffer from branches being shut down due to the widespread of the virus. Banks, and especially Islamic banks in Bahrain, had to revaluate their operations in order to adapt to the impact that COVID had on the Bahraini economy. In the case of Islamic banks worldwide, they had to rapidly change in terms of their business environment and operations in order to adapt to the situation they were in during the pandemic while also ensure the safety and wellbeing of both their staff and customers. Several studies have been made regarding the impact of COVID on the performance of Islamic banks, and the different financial indicators that determine the financial risks impacted as well. However, the studies were only limited to countries outside the GCC and focusing on comparing the impacts of COVID on both Islamic and Conventional banks. This study focuses on the impact that COVID had on the profitability of Islamic banks based in Bahrain by analysing Return on Assets (ROA) as a profitability measure and dependent variable. Independent variables that are used in the study are: capital adequacy ratio, current ratio as a liquidity risk measure, change in operating income as a growth measure. In addition, macro-economic factors are considered in the analysis such as GDP and inflation. Dummy variables for the study include the years 2020 and 2021 to indicate if there is an impact from COVID on the performance of Islamic banks. Correspondingly, the years 2008 and 2009 will also be included for the financial crisis dummy variable. The study is based on five different Islamic banks based in Bahrain, which are: Albaraka, Kuwait Financial House (KFH), Ithmaar bank, Bank ABC, and Alsalam bank. Data are extracted from annual reports published on the banks’ website` over a 14-year sample period to analyse the impacts that both the financial crises and COVID had on the performance of Islamic banks. Using quantitative panel data analysis, the study uses the random effects regression model and generalized least squares. By looking into the literature and results, the study concludes that COVID did not have a significant impact on the profitability of Islamic Banks in Bahrain.
Additional file 1 of Development and evaluation of the Singapore Caregiver Quality of Life Scale - Dementia
Creators: name: Cheung, Yin Bun
name: Teo, Irene
name: Wee Shiong Lim
name: Hum, Allyn
name: Shirlyn H. S. Neo
name: Yang, Grace M.
name: Geok Ling Lee
name: Tan, Gretchen
name: Seow, Dennis C. C.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Online Supplementary Material S1. Factor loadings in confirmatory factor analysis of a 5-factor model, with each item loaded on one factor.
Synthesis and Antibacterial Evaluation of Cephalosporin Isosteres
Creators: name: Somersan Karakaya, S.
name: Ling, Y.
name: Roberts, J.
name: Lopez Quezada, L.
name: Saito, K.
name: Abramyan, T.M.
name: Kireev, D.B.
name: Javidnia, P.E.
name: Zhang, D.
name: Cesta, D.J.
name: Gold, B.S.
name: Scarry, S.M.
name: Aubé, J.
Publisher: name: Wiley-VCH Verlag
Year: 2019

description: As part of a program to explore the chemistry of β-lactams and their derivatives, we prepared a focused set of benzazetidine, indoline, and indole heterocycles, as well as flexible unconstrained variations of the four-membered heterocyclic compounds. These analogues mimic the three-dimensional shape of cephalosporins but are not prone to covalent binding via ring opening. Although these analogues were inactive against the ESKAPE pathogens and Mtb, they represent unique and underexplored chemotypes for future biological screening.
(502543) Geoffrey Brereton
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Spectral statistics of nearly unidirectional quantum graphs
Creators: name: Akila, Maram
name: Gutkin, Boris
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: The energy levels of a quantum graph with time reversal symmetry and unidirectional classical dynamics are doubly degenerate and obey the spectral statistics of the Gaussian Unitary Ensemble. These degeneracies, however, are lifted when the unidirectionality is broken in one of the graph's vertices by a singular perturbation. Based on a Random Matrix model we derive an analytic expression for the nearest neighbour distribution between energy levels of such systems. As we demonstrate the result agrees excellently with the actual statistics for graphs with a uniform distribution of eigenfunctions. Yet, it exhibits quite substantial deviations for classes of graphs which show strong scarring.
description: 23 pages, 13 figures (changes: more details on the derivation of $F_{k,l}$ added, minor corrections)
Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis
Creators: name: Liang, H.-P.H.
name: Porras De Francisco, E.
name: Amieva, M.M.
name: Zhang, J.
name: Dartois, V.
name: Saito, K.
name: Nguyen, Q.
name: Javidnia, P.E.
name: Pharr, C.W.
name: Somersan Karakaya, S.
name: Zimmerman, M.
name: Roberts, J.
name: Goullieux, L.
name: Nathan, C.
name: Lagrange, S.
name: Lopez Quezada, L.
name: Aubé, J.
name: Mendoza Losana, A.
name: Gold, B.
name: Li, K.
name: Dĺaz, S.P.
name: Roubert, C.
name: McAulay, K.
name: Perkowski, A.J.
name: Sans, S.
name: McDonald, S.L.
Publisher: name: American Chemical Society
Year: 2019

description: The historical view of β-lactams as ineffective antimycobacterials has given way to growing interest in the activity of this class against Mycobacterium tuberculosis (Mtb) in the presence of a β-lactamase inhibitor. However, most antimycobacterial β-lactams kill Mtb only or best when the bacilli are replicating. Here, a screen of 1904 β-lactams led to the identification of cephalosporins substituted with a pyrithione moiety at C3′ that are active against Mtb under both replicating and nonreplicating conditions, neither activity requiring a β-lactamase inhibitor. Studies showed that activity against nonreplicating Mtb required the in situ release of the pyrithione, independent of the known class A β-lactamase, BlaC. In contrast, replicating Mtb could be killed both by released pyrithione and by the parent β-lactam. Thus, the antimycobacterial activity of pyrithione-containing cephalosporins arises from two mechanisms that kill mycobacteria in different metabolic states.
(502552) Henry George Calcraft
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 2 of Development and evaluation of the Singapore Caregiver Quality of Life Scale - Dementia
Creators: name: Cheung, Yin Bun
name: Teo, Irene
name: Wee Shiong Lim
name: Hum, Allyn
name: Shirlyn H. S. Neo
name: Yang, Grace M.
name: Geok Ling Lee
name: Tan, Gretchen
name: Seow, Dennis C. C.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2: Online Supplementary Material S2. Spearman’s correlation coefficients between each item and its belonging domain and other domains.
Additional file 3 of Opening the door to university health research: recommendations for increasing accessibility for individuals with intellectual disability
Creators: name: St. John, Brittany M.
name: Hickey, Emily
name: Kastern, Edward
name: Russell, Chad
name: Russell, Tina
name: Mathy, Ashley
name: Peterson, Brogan
name: Wigington, Don
name: Pellien, Casey
name: Caudill, Allison
name: Hladik, Libby
name: Ausderau, Karla K.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Science Policy

description: Additional file 3.
A magnetic thermal switch for heat management at the nanoscale
Creators: name: Bosisio, Riccardo
name: Valentini, Stefano
name: Mazza, Francesco
name: Benenti, Giuliano
name: Fazio, Rosario
name: Giovannetti, Vittorio
name: Taddei, Fabio
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In a multi-terminal setup, when time-reversal symmetry is broken by a magnetic field, the heat flows can be managed by designing a device with programmable Boolean behavior. We show that such device can be used to implement operations like on/off switching, reversal, selected splitting and swap of the heat currents. For each feature, the switching from one working condition to the other is obtained by inverting the magnetic field. This offers interesting opportunities of conceiving a programmable setup, whose operation is controlled by an external parameter (the magnetic field) without need to alter voltage and thermal biases applied to the system. Our results, generic within the framework of linear response, are illustrated by means of a three-terminal electronic interferometer model.
description: 7+ pages, 4 figures
Online Dating Offlineräume Cologne
Creators: name: Bothe, Andia Adèl
name: Nobarianasl, Negin
name: Holewa, Michelle
name: Reichstein, Annika
name: Algan, Anil
name: Gerges, Rani
name: Ziarkiewicz, Kevin
name: Turba, Lara
name: Däubner, Anna-Lena
name: Du, Minyue
name: Zhuqing, Luo
Publisher: name: RWTH Aachen University
Year: 2023
Subjects: Alltagslayer
Onlinedating
Post-Corona-Stadt Köln
Verräumlichung
digitale Vernetzung

description: Course work, RWTH Aachen, 2023; Aachen : RWTH Aachen University, Lehrstuhl für Städtebau und Entwerfen 37 Seiten : Illustrationen (2023). = Course work, RWTH Aachen, 2023
description: Published by RWTH Aachen University, Lehrstuhl für Städtebau und Entwerfen, Aachen
Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis
Creators: name: Rudloff, U.
name: Knotts, Z.
name: Long, C.
name: Bian, Y.
name: Teper, Y.
name: Lewandowska, M.A.
name: Griner, L.M.
name: Norton, J.
name: Aubé, J.
name: Schoenen, F.J.
name: Mazar, A.
name: Shilatifard, A.
name: Sun, W.
name: Kang, J.
name: Marugan, J.J.
name: Li, D.
name: Southall, N.
name: Huang, S.
name: Baserga, S.J.
name: Ferrer, M.
name: Powers, A.S.
name: Wang, C.
name: Quadri, H.S.
name: Frankowski, K.J.
name: Huang, H.
name: Chen, W.
name: Kim, H.R.
name: Chow, E.
name: Zheng, W.
name: Zhou, M.
name: Hu, D.
name: Titus, S.
name: Vilimas, T.
name: Wen, Y.
name: Dextras, C.
name: Nagashima, K.
name: Sultan, J.
name: Fang, M.
name: Kozlov, S.
name: Kandela, I.
name: Goldberg, E.
name: Khanolkar, O.
name: Patnaik, S.
name: Farley, K.I.
name: Feldman, C.
name: Meng, Z.
name: Xi, R.
name: Sahagian, G.
Publisher: name: American Association for the Advancement of Science
Year: 2018

description: Metastasis remains a leading cause of cancer mortality due to the lack of specific inhibitors against this complex process. To identify compounds selectively targeting the metastatic state, we used the perinuclear compartment (PNC), a complex nuclear structure associated with metastatic behaviors of cancer cells, as a phenotypic marker for a high-content screen of over 140,000 structurally diverse compounds. Metarrestin, obtained through optimization of a screening hit, disassembles PNCs in multiple cancer cell lines, inhibits invasion in vitro, suppresses metastatic development in three mouse models of human cancer, and extends survival of mice in a metastatic pancreatic cancer xenograft model with no organ toxicity or discernable adverse effects. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2. Thus, metarrestin represents a potential therapeutic approach for the treatment of metastatic cancer.
Abhängigkeiten zwischen Prognose und Therapie epileptischer Anfälle
Creators: name: Vorderwülbecke, Bernd
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2023
Subjects: subject: acute symptomatic seizure
subject: antiseizure medication
subject: long-term seizure outcome
subject: idiopathic generalised epilepsy
subject: genetic generalised epilepsy
subject: EEG source localisation
subject: presurgical epilepsy evaluation
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Bei epileptischen Anfällen müssen Therapieentscheidungen und individuelle Anfallsprognose konsequent zusammengedacht werden. In der Akutmedizin gibt es hierzu noch Optimierungsbedarf: Bei 50-75% derjenigen, die mit einer auf der Intensivstation initiierten anfallssupprimierenden Therapie von dort weiterverlegt werden, besteht wegen des geringen Risikos weiterer Anfälle keine Indikation für eine langfristige Behandlung. Arbeiten zum Langzeitverlauf idiopathischer generalisierter Epilepsien zeigen, dass sich die Anfallsprognose mit zunehmendem Lebensalter immer weiter bessert, sodass nach langjähriger Anfallsfreiheit ein Ende der Anfallsprophylaxe erwogen werden sollte. Auch ist die Langzeitprognose der vier idiopathischen generalisierten Epilepsien überraschend homogen, was die Hypothese stützt, dass es sich bei ihnen um unterschiedliche Ausprägungsarten ein und desselben neurobiologischen Kontinuums handelt. In der prächirurgischen Epilepsiediagnostik müssen die konkreten Herangehensweisen zur interiktalen EEG-Quellenlokalisation mit Bedacht ausgewählt werden, so u. a. die verwendeten Elektroden in Abhängigkeit vom genutzten Kopfmodell. Vermeintlich modernere Algorithmen bringen nicht zwangsläufig eine verbesserte Präzision mit sich, und das hochauflösende EEG mit mehr als 64 Elektroden ist dem konventionellen, niedrigauflösenden EEG für die interiktale EEG-Quellenlokalisation nicht zwangsläufig überlegen, wie die Validierung anhand der postoperativen Anfallssituation zeigt.
(502539) Francis Milburn Brereton
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 4 of Opening the door to university health research: recommendations for increasing accessibility for individuals with intellectual disability
Creators: name: St. John, Brittany M.
name: Hickey, Emily
name: Kastern, Edward
name: Russell, Chad
name: Russell, Tina
name: Mathy, Ashley
name: Peterson, Brogan
name: Wigington, Don
name: Pellien, Casey
name: Caudill, Allison
name: Hladik, Libby
name: Ausderau, Karla K.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Science Policy

description: Additional file 4.
Additional file 5 of Opening the door to university health research: recommendations for increasing accessibility for individuals with intellectual disability
Creators: name: St. John, Brittany M.
name: Hickey, Emily
name: Kastern, Edward
name: Russell, Chad
name: Russell, Tina
name: Mathy, Ashley
name: Peterson, Brogan
name: Wigington, Don
name: Pellien, Casey
name: Caudill, Allison
name: Hladik, Libby
name: Ausderau, Karla K.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Science Policy

description: Additional file 5.
Signals of Bose Einstein condensation and Fermi quenching in the decay of hot nuclear systems
Creators: name: Marini, P.
name: Zheng, H.
name: Boisjoli, M.
name: Verde, G.
name: Chbihi, A.
name: Ademard, G.
name: Auger, L.
name: Bhattacharya, C.
name: Borderie, B.
name: Bougault, R.
name: Frankland, J.
name: Galichet, E.
name: Gruyer, D.
name: Kundu, S.
name: La Commara, M.
name: Lombardo, I.
name: Lopez, O.
name: Mukherjee, G.
name: Napolitani, P.
name: Parlog, M.
name: Rivet, M. F.
name: Rosato, E.
name: Roy, R.
name: Spadaccini, G.
name: Vigilante, M.
name: Wigg, P. C.
name: Bonasera, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We report experimental signals of Bose-Einstein condensation in the decay of hot Ca projectile-like sources produced in mid-peripheral collisions at sub-Fermi energies. The experimental setup, constituted by the coupling of the INDRA 4$π$ detector array to the forward angle VAMOS magnetic spectrometer, allowed us to reconstruct the mass, charge and excitation energy of the decaying hot projectile-like sources. Furthermore, by means of quantum fluctuation analysis techniques, temperatures and mean volumes per particle "as seen by" bosons and fermions separately are correlated to the excitation energy of the reconstructed system. The obtained results are consistent with the production of dilute mixed (bosons/fermions) systems, where bosons experience a smaller volume as compared to the surrounding fermionic gas. Our findings recall similar phenomena observed in the study of boson condensates in atomic traps.
description: Submitted to Phys. Rev. Lett. (december 2014)
G protein signaling-biased agonism at the k-opioid receptor is maintained in striatal neurons
Creators: name: Stahl, E.L.
name: Ho, J.-H.
name: Bohn, L.M.
name: Scarry, S.M.
name: Aubé, J.
name: Schmid, C.L.
Publisher: name: American Association for the Advancement of Science
Year: 2018

description: Biased agonists of G protein-coupled receptors may present a means to refine receptor signaling in a way that separates side effects from therapeutic properties. Several studies have shown that agonists that activate the k-opioid receptor (KOR) in a manner that favors G protein coupling over b-Arrestin2 recruitment in cell culture may represent a means to treat pain and itch while avoiding sedation and dysphoria. Although it is attractive to speculate that the bias between G protein signaling and b-Arrestin2 recruitment is the reason for these divergent behaviors, little evidence has emerged to show that these signaling pathways diverge in the neuronal environment. We further explored the influence of cellular context on biased agonism at KOR ligand-directed signaling toward G protein pathways over b-Arrestin-dependent pathways and found that this bias persists in striatal neurons. These findings advance our understanding of how a G protein-biased agonist signal differs between cell lines and primary neurons, demonstrate that measuring [35S]GTPgS binding and the regulation of adenylyl cyclase activity are not necessarily orthogonal assays in cell lines, and emphasize the contributions of the environment to assessing biased agonism .
Inefficient star formation through turbulence, magnetic fields and feedback
Creators: name: Federrath, Christoph
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Star formation is inefficient. Only a few percent of the available gas in molecular clouds forms stars, leading to the observed low star formation rate (SFR). The same holds when averaged over many molecular clouds, such that the SFR of whole galaxies is again surprisingly low. Indeed, considering the low temperatures, molecular clouds should be highly gravitationally unstable and collapse on their global mean freefall timescale. And yet, they are observed to live about 10-100 times longer, i.e., the SFR per freefall time (SFR_ff) is only a few percent. Thus, other physical mechanisms must counteract the quick global collapse. Turbulence, magnetic fields and stellar feedback have been proposed as regulating agents, but it is still unclear which of these processes is the most important and what their relative contributions are. Here we run high-resolution simulations including gravity, turbulence, magnetic fields, and jet/outflow feedback. We confirm that clouds collapse on a mean freefall time, if only gravity is considered, producing stars at an unrealistic rate. In contrast, if turbulence, magnetic fields, and feedback are included step-by-step, the SFR is reduced by a factor of 2-3 with each additional physical ingredient. When they all act in concert, we find a constant SFR_ff = 0.04, currently the closest match to observations, but still about a factor of 2-4 higher than the average. A detailed comparison with other simulations and with observations leads us to conclude that only models with turbulence producing large virial parameters, and including magnetic fields and feedback can produce realistic SFRs.
description: 9 pages, 3 figures, MNRAS, in press, movies available: http://www.mso.anu.edu.au/~chfeder/pubs/ineff_sf/ineff_sf.html, see also astrobite article: http://astrobites.org/2015/04/28/why-is-star-formation-so-inefficient/
Additional file 1 of Positive and negative syndrome scale in forensic patients with schizophrenia spectrum disorders: a systematic review and meta-analysis
Creators: name: Buizza, Chiara
name: Strozza, Cosmo
name: Sbravati, Giulio
name: de Girolamo, Giovanni
name: Ferrari, Clarissa
name: Iozzino, Laura
name: Macis, Ambra
name: Kennedy, Harry G.
name: Candini, Valentina
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. Methodological quality assessment and risk of bias
Additional file 1 of Risk perception related to COVID-19 among the Iranian general population: an application of the extended parallel process model
Creators: name: Jahangiry, Leila
name: Bakhtari, Fatemeh
name: Sohrabi, Zahara
name: Reihani, Parvin
name: Sirous Samei
name: Ponnet, Koen
name: Montazeri, Ali
Publisher: name: figshare
Year: 2020
Subjects: subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Additional file 1. The Risk-Percept COVID-19 Questionnaire. The file contains a 29-items questionnaire which was specially developed for the study.
(502540) Hugh Brereton
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 2 of Positive and negative syndrome scale in forensic patients with schizophrenia spectrum disorders: a systematic review and meta-analysis
Creators: name: Buizza, Chiara
name: Strozza, Cosmo
name: Sbravati, Giulio
name: de Girolamo, Giovanni
name: Ferrari, Clarissa
name: Iozzino, Laura
name: Macis, Ambra
name: Kennedy, Harry G.
name: Candini, Valentina
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2: Table S1. Cochrane quality assessment tool.
Additional file 1 of Analysis of low-dose estrogen on callus BMD as measured by pQCT in postmenopausal women
Creators: name: K. Jäckle
name: J. P. Kolb
name: A. F. Schilling
name: C. Schlickewei
name: M. Amling
name: J. M. Rueger
name: W. Lehmann
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Hematology

description: Additional file 1. CONSORT guidelines. The study was performed according to the CONSORT guidelines. (DOC 220 kb)
Additional file 3 of Positive and negative syndrome scale in forensic patients with schizophrenia spectrum disorders: a systematic review and meta-analysis
Creators: name: Buizza, Chiara
name: Strozza, Cosmo
name: Sbravati, Giulio
name: de Girolamo, Giovanni
name: Ferrari, Clarissa
name: Iozzino, Laura
name: Macis, Ambra
name: Kennedy, Harry G.
name: Candini, Valentina
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 3: Table S2. NOS Scale for cohort and case-control studies.
(502541) Richard Augustus Brereton
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
NIHAO project I: Reproducing the inefficiency of galaxy formation across cosmic time with a large sample of cosmological hydrodynamical simulations
Creators: name: Wang, Liang
name: Dutton, Aaron A.
name: Stinson, Gregory S.
name: Macciò, Andrea V.
name: Penzo, Camilla
name: Kang, Xi
name: Keller, Ben W.
name: Wadsley, James
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We introduce project NIHAO (Numerical Investigation of a Hundred Astrophysical Objects), a set of 100 cosmological zoom-in hydrodynamical simulations performed using the gasoline code, with an improved implementation of the SPH algorithm. The haloes in our study range from dwarf to Milky Way masses, and represent an unbiased sampling of merger histories, concentrations and spin parameters. The particle masses and force softenings are chosen to resolve the mass profile to below 1% of the virial radius at all masses, ensuring that galaxy half-light radii are well resolved. Using the same treatment of star formation and stellar feedback for every object, the simulated galaxies reproduce the observed inefficiency of galaxy formation across cosmic time as expressed through the stellar mass vs halo mass relation, and the star formation rate vs stellar mass relation. We thus conclude that stellar feedback is the chief piece of physics required to limit the efficiency of star formation in galaxies less massive than the Milky Way.
description: 14 pages, 8 figures, accepted for publication in MNRAS
Supersymmetry for Products of Random Matrices
Creators: name: Kieburg, Mario
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We consider the singular value statistics of products of independent random matrices. In particular we compute the corresponding averages of products of characteristic polynomials. To this aim we apply the projection formula recently introduced for chiral random matrix ensembles which serves as a short cut of the supersymmetry method. The projection formula enables us to study the local statistics where free probability currently fails. To illustrate the projection formula and underlining the power of our approach we calculate the hard edge scaling limit of the Meijer G-ensembles comprising the Wishart-Laguerre (chiral Gaussian), the Jacobi (truncated orthogonal, unitary or unitray symplectic) and the Cauchy-Lorentz (heavy tail) random matrix ensembles. All calculations are done for real, complex, and quaternion matrices in a unifying way. In the case of real and quaternion matrices the results are completely new and point to the universality of the hard edge scaling limit for a product of these matrices, too. Moreover we identify the non-linear $σ$-models corresponding to product matrices.
description: content partially presented in a talk at "Random Matrix Theory: Foundations and Applications" in Cracow, July 1-6 2014,18 pages, PACS: 02.10.Yn, 02.50.Sk, 05.40.-a
Additional file 4 of Positive and negative syndrome scale in forensic patients with schizophrenia spectrum disorders: a systematic review and meta-analysis
Creators: name: Buizza, Chiara
name: Strozza, Cosmo
name: Sbravati, Giulio
name: de Girolamo, Giovanni
name: Ferrari, Clarissa
name: Iozzino, Laura
name: Macis, Ambra
name: Kennedy, Harry G.
name: Candini, Valentina
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 4: Table S3. NOS Scale for cross-sectional studies.
Additional file 5 of Positive and negative syndrome scale in forensic patients with schizophrenia spectrum disorders: a systematic review and meta-analysis
Creators: name: Buizza, Chiara
name: Strozza, Cosmo
name: Sbravati, Giulio
name: de Girolamo, Giovanni
name: Ferrari, Clarissa
name: Iozzino, Laura
name: Macis, Ambra
name: Kennedy, Harry G.
name: Candini, Valentina
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 5: Table S4. Comparison between PANSS total rating and CGI. ratings, and clinical meaning.
Synthesis, stabilization, and characterization of the MR1 ligand precursor 5-amino-6-D-ribitylaminouracil (5-A-RU)
Creators: name: Aubé, J.
name: Bell, D.L.
name: Li, K.
name: Altman, J.D.
name: Chaudhry, A.
name: Willis, R.A.
name: Glickman, M.S.
name: Rudensky, A.
name: Vorkas, C.K.
Publisher: name: Public Library of Science
Year: 2018

description: Mucosal-associated invariant T (MAIT) cells are an abundant class of innate T cells restricted by the MHC I-related molecule MR1. MAIT cells can recognize bacterially-derived metabolic intermediates from the riboflavin pathway presented by MR1 and are postulated to play a role in innate antibacterial immunity through production of cytokines and direct bacterial killing. MR1 tetramers, typically stabilized by the adduct of 5-amino-6-D-ribitylaminour-acil (5-A-RU) and methylglyoxal (MeG), are important tools for the study of MAIT cells. A long-standing problem with 5-A-RU is that it is unstable upon storage. Herein we report an efficient synthetic approach to the HCl salt of this ligand, which has improved stability during storage. We also show that synthetic 5-A-RU•HCl produced by this method may be used in protocols for the stimulation of human MAIT cells and production of both human and mouse MR1 tetramers for MAIT cell identification.
(502542) John Brereton
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Water Trapping on Tidally Locked Terrestrial Planets Requires Special Conditions
Creators: name: Yang, Jun
name: Liu, Yonggang
name: Hu, Yongyun
name: Abbot, Dorian S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Surface liquid water is essential for standard planetary habitability. Calculations of atmospheric circulation on tidally locked planets around M stars suggest that this peculiar orbital configuration lends itself to the trapping of large amounts of water in kilometers-thick ice on the night side, potentially removing all liquid water from the day side where photosynthesis is possible. We study this problem using a global climate model including coupled atmosphere, ocean, land, and sea-ice components as well as a continental ice sheet model driven by the climate model output. For a waterworld we find that surface winds transport sea ice toward the day side and the ocean carries heat toward the night side. As a result, night-side sea ice remains O(10 m) thick and night-side water trapping is insignificant. If a planet has large continents on its night side, they can grow ice sheets O(1000 m) thick if the geothermal heat flux is similar to Earth's or smaller. Planets with a water complement similar to Earth's would therefore experience a large decrease in sea level when plate tectonics drives their continents onto the night side, but would not experience complete day-side dessication. Only planets with a geothermal heat flux lower than Earth's, much of their surface covered by continents, and a surface water reservoir O(10 %) of Earth's would be susceptible to complete water trapping.
description: 9 pages, 5 figures, The Astrophysical Journal Letters (accepted)
Additional file 1 of The first consecutive 5000 patients with Coronavirus Disease 2019 from Qatar; a nation-wide cohort study
Creators: name: Omrani, Ali S.
name: Almaslamani, Muna A.
name: Daghfal, Joanne
name: Alattar, Rand A.
name: Elgara, Mohamed
name: Shahd H. Shaar
name: Tawheeda B. H. Ibrahim
name: Zaqout, Ahmed
name: Bakdach, Dana
name: Abdelrauof M. Akkari
name: Baiou, Anas
name: Alhariri, Bassem
name: Elajez, Reem
name: Husain, Ahmed A. M.
name: Badawi, Mohamed N.
name: Abid, Fatma Ben
name: Sulieman H. Abu Jarir
name: Shiema Abdalla
name: Kaleeckal, Anvar
name: Choda, Kris
name: Venkateswara R. Chinta
name: Sherbash, Mohamed A.
name: Al-Ismail, Khalil
name: Abukhattab, Mohammed
name: Hssain, Ali Ait
name: Coyle, Peter V.
name: Bertollini, Roberto
name: Frenneaux, Michael P.
name: Abdullatif Alkhal
name: Al-Kuwari, Hanan M.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Computational Biology

description: Additional file 1 Table S1. Baseline characteristics and outcomes of 5000 individuals with Coronavirus Disease 2019 in Qatar. Table S2. Coronavirus Disease 2019-associated deaths in Qatar. Table S3. Pregnant women with Coronavirus Disease 2019 in Qatar. Table S4. Healthcare Workers with Coronavirus Disease 2019 in Qatar. Table S5. Children with Coronavirus Disease 2019 in Qatar. Table S6. Qatar population and corresponding SARS-CoV-2 infection incidence per 100,000 population by sex and age group.
Hexafluoro-2-propanol-promoted intramolecular friedel-crafts acylation
Creators: name: Vekariya, R.H.
name: Horton, M.C.
name: Aubé, J.
Publisher: name: Wiley Blackwell
Year: 2018

description: A. 4-(3,4-Dimethoxyphenyl)butanoyl chloride (2). An oven-dried, 250-mL, three-necked, 14/20 round-bottomed flask is equipped with an egg-shaped magnetic stir bar (2 cm), a pressure-equalizing addition funnel (25 mL), a rubber septum, and an argon inlet (Figure 1). The flask is charged with 4- (3,4-dimethoxyphenyl)butanoic acid (1) (7.25 g, 32.3 mmol, 1.0 equiv) (Note 2), anhydrous DCM (40 mL) (Note 3) and DMF (50. μL, 0.65 mmol, 0.02 equiv) (Note 4). Oxalyl chloride (5.5 mL, 64 mmol, 2.0 equiv) (Note 5) is added via syringe to the addition funnel, and the stopcock is opened such that the oxalyl chloride is added over 4 min, resulting in effervescence. The reaction mixture is stirred at 23 °C for 30 min from the start of the addition of oxalyl chloride (Note 6). The argon inlet is replaced with a rubber septum, the addition funnel is removed, and the flask placed on a rotary evaporator. Concentration under reduced pressure (35 °C, 30 mm Hg) afforded 8.35 g of crude acid chloride (2) as a yellow oil (Note 7 and 8), which is used in the next step without purification.
The Relationship of Childhood Factors on the Development of Women Leadership: An Analysis of Developing and Developed Countries
Creators: name: Alhuwaider, Razan
Publisher: name: American University of Bahrain
Year: 2023
Subjects: classificationCode: 350707
subject: Leadership
classificationCode: 52
subject: Psychology
subject: FOS: Psychology

description: The study is focused on women leadership and the shortage of opportunities in society in developing and developed countries. The goal is to categorize and investigate common childhood experiences of women leaders through; intrapersonal factors (childhood vales) and external factors (Family and parents, education, economic status, religion) (Madsen, 2007; Toman, 2008; Bradley, 2011; Guerin, et al.,2011; Akstinaite, 2016). Providing information that may be used to make suggestions to schools about women leadership development, to generate a bigger pool and opportunities of future women leaders (Toman, 2008). The study uses data from the World Values Survey (WVS) to investigate the impact of childhood values, family environment, education, economic status, and religion on women's leadership. The study defines women's leadership as those in positions requiring leadership skills and qualities, such as managers, doctors, and business owners. A mixed methods approach was chosen to better support the research, analyzing both quantitate variables and qualitative variables. First descriptive analysis, about each question from the survey is conducted. In depth information about leaders’ childhood are provided by comparing the independent variables with the dependent variable. Additionally, the statistical quantitative section will investigate the hypotheses using models to further analyze the significance of the study. The results of the models revealed several common childhood experiences that affect women leadership (Madsen, 2007; Toman, 2008; Bradley, 2011; Akstinaite, 2016). Significant factors were found, where family environment had the highest positive correlation, education also had a positive relation, religion had the highest negative correlation, as for economic status it also had a significant negative correlation although it is weak it is supported by the literature. The findings of the study imply that certain experiences in childhood and adolescence may contribute to women’s potential to become a successful leader (Madsen, 2007; Adler & Management, 2008; Toman, 2008; Bradley, 2011; Guerin, et al., 2011; Akstinaite, 2016). These skills develop at a far younger age, than what most research papers about women leadership development target (Toman, 2008). Collecting information about successful women leaders in the MENA region for this research, fills that gap and benefits women leaders.
ChatGPT guidance for reproductive specialists: Dr. Jekyll or Mr. Hyde?
Creators: name: Sengupta, Pallav
name: Dutta, Sulagna
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2023
Subjects: Artificial Intelligence (AI)
ChatGPT
reproductive medicine

description: EXCLI Journal; 22:Doc911; ISSN 1611-2156
(502538) Mary Andrews
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.