cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Head and Arm Tremor in X-linked Spinal and Bulbar Muscular Atrophy
Creators: name: Aicua, Irene
name: Verhagen, Okker
name: Arenaza, Naroa
name: Cubo, Esther
Publisher: name: Columbia University
Year: 2014
Subjects: subject: Neurosciences
subject: FOS: Clinical medicine

description: Background: X-linked spinal and bulbar muscular atrophy (SBMA) is a rare adult-onset neuronopathy. Although tremor is known to occur in this disease, the number of reported cases of SBMA with tremor is rare, and the number with videotaped documentation is exceedingly rare. Our aim was to describe/document the characteristic signs of tremor in spinal and bulbar muscular atrophy.

Case Report: We report a case of a 58-year-old male with a positive family history of tremor. On examination, the patient had jaw and hand tremors but he also exhibited gynecomastia, progressive bulbar paresis, and wasting and weakness primarily in the proximal limb muscles. The laboratory tests revealed an elevated creatine phosphokinase. Genetic testing was positive for X-SBMA, with 42 CAG repeats.

Discussion: Essential tremor is one of the most common movement disorders, yet it is important for clinicians to be aware of the presence of other distinguishing features that point to alternative diagnoses. The presence of action tremor associated with muscle atrophy and gynecomastia should lead to a suspicion of SBMA.

Keywords: Tremor, Kennedy's disease, X-linked spinal and bulbar muscular atrophy, CAG repeats

Citation: Aicua I, Verhagen O, Arenaza N, et al. Head and arm tremor in X-linked spinal and bulbar muscular atrophy. Tremor Other Hyperkinet Mov. 2014; 4. doi: 10.7916/D8959FVJ
Partition Pooling for Convolutional Graph Network Applications in Particle Physics
Creators: name: Bachlechner, M.
name: Birkenfeld, T.
name: Soldin, P.
name: Stahl, A.
name: Wiebusch, C.
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: Machine Learning (cs.LG)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Convolutional graph networks are used in particle physics for effective event reconstructions and classifications. However, their performances can be limited by the considerable amount of sensors used in modern particle detectors if applied to sensor-level data. We present a pooling scheme that uses partitioning to create pooling kernels on graphs, similar to pooling on images. Partition pooling can be used to adopt successful image recognition architectures for graph neural network applications in particle physics. The reduced computational resources allow for deeper networks and more extensive hyperparameter optimizations. To show its applicability, we construct a convolutional graph network with partition pooling that reconstructs simulated interaction vertices for an idealized neutrino detector. The pooling network yields improved performance and is less susceptible to overfitting than a similar network without pooling. The lower resource requirements allow the construction of a deeper network with further improved performance.
Can a planet explain different cavity sizes for small and large dust grains in transition disks?
Creators: name: Garufi, Antonio
name: Avenhaus, Henning
name: Quanz, Sascha Patrick
Publisher: name: arXiv
Year: 2013
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Dissimilarities in the spatial distribution of small (micron-size) and large (millimeter-size) dust grains at the cavity edge of transition disks have been recently pointed out and are now under debate. We obtained VLT-NACO near-IR polarimetric observations of SAO 206462 (HD135344B). The disk around the star shows very complex structures, such as dips and spirals. We also find an inner cavity much smaller than what inferred from sub-mm images. The interaction between disk and orbiting companion(s) may explain this discrepancy.
description: 2 pages, 2 figures, proceedings IAU Symposium No. 299, 2013
Regarding the English: The Certificate in ELS Language Center Certified at Level 9. _(Siming Zheng) for HKU
Creators: name: Siming Zheng
Publisher: name: figshare
Year: 2020
Subjects: subject: 200303 English as a Second Language
subject: FOS: Languages and literature

description: Supporting English document:
The Certificate of Nine-level Certified Intensive Programme in English, ELS Language Center.
1. This ELS certificate is divided into the levels 5 to 9, and the highest level is 9.
2. I passed the final exam at level 9 and obtained the ELS certificate, which was certified at level 9.
Status: Passed and Awarded
Location: ELS Language Center, Kuala Lumpur City, Malaysia
Thank you for your reference.

Best regards,
Applicant: Siming Zheng
Sesquiterpenes rich essential oil from Garcinia celebica L. and its cytotoxic and antimicrobial activities
Creators: name: Wen-Nee Tan
name: Tan, Zi-Hui
name: Zulkifli, Nurul Izzati
name: Kamal, Nik Nur Syazni Nik Mohamed
name: Rozman, Nur Amiera Syuhada
name: Woei-Yenn Tong
name: Chean-Ring Leong
name: Lim, Jun-Wei
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified

description: Garcinia celebica L., locally known as “manggis hutan” in Malaysia is widely used in folkloric medicine to treat various diseases. The present study was aimed to examine the chemical composition of the essential oil from the leaves of G. celebica L. (EO-GC) and its cytotoxic and antimicrobial potential. EO-GC obtained by hydrodistillation was analysed using capillary GC and GC-MS. Twenty-two compounds were identified, dominated by α-copaene (61.25%), germacrene D (6.72%) and β-caryophyllene (5.85%). In the in vitro MTT assay, EO-GC exhibited significant anti-proliferative effects towards MCF-7 human breast cancer cells with IC50 value of 45.2 μg/mL. Regarding the antimicrobial activity, it showed better inhibitory effects on Gram-positive bacteria than Gram-negative bacteria and none on the fungi and yeasts tested.
Toxicity effects of Eriocephalus africanus L. leaf essential oil against some molecularly identified phytopathogenic bacterial strains
Creators: name: Behiry, Said I.
name: Mervat EL-Hefny
name: Salem, Mohamed Z. M.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Essential oil (EO) from Eriocephalus africanus L. leaves was evaluated against the growth of some phytopathogenic bacteria including Agrobacerium tumifaciens, Dickeya solani, Erwinia amylovora, Pseudomonas cichorii and Serratia pulmithica using the disc diffusion method and minimum inhibitory concentration (MIC) evaluation. Ten compounds in the EO with dominance of Artemisia ketone (2,5,5-trimethyl-2,6-heptadien-4-one) (77.92%) and ledol (19.92%) were revealed. The antibacterial activity indicated efficacy of essential oil against majority of strains isolated. The most effective action was recorded against D. solani, by 7.5 and 10 µL of oil, with 18.33 mm and 100 μg/mL as zone inhibition and MIC, respectively, whereas the lowest activity was exhibited against P. cichorii (diameter inhibition = 6.66 mm at 10 µL of oil, MIC = 100 μg/mL). The strain S. pulmithica appears to be resistant to the oil when the activity is measured by 10 µL of oil but its growth inhibition was reported with a MIC of 100 μg/mL.
Next-to-leading order electroweak corrections to pp -> W+W- -> 4 leptons at the LHC in double-pole approximation
Creators: name: Billoni, M.
name: Dittmaier, S.
name: Jager, B.
name: Speckner, C.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We present the calculation of next-to-leading-order electroweak corrections to W-boson pair production at the LHC, taking off-shell effects of the W bosons and their leptonic decays into account in the framework of the so-called double-pole approximation. In detail, the lowest-order cross section and the photonic bremsstrahlung are based on full matrix elements with four-fermion final states, but the virtual one-loop corrections are approximated by the leading contributions of a systematic expansion about the resonance poles of the two W bosons. This expansion classifies the virtual corrections into factorizable and non-factorizable corrections, the calculation of which is described in detail. Corrections induced by photons in the initial state, i.e. photon-photon and quark-photon collision channels, are included and based on complete matrix elements as well. Our numerical results, which are presented for realistic acceptance cuts applied to the W-boson decay products, qualitatively confirm recent results obtained for on-shell W bosons and reveal electroweak corrections of the size of tens of percent in the TeV range of transverse momenta and invariant masses. In general, photon-photon and quark-photon induced contributions amount to 5-10% of the full differential result. Compared to previous predictions based on stable W bosons electroweak corrections, however, can change by several percent because of realistic cuts on the W-boson decay products and corrections to the decays.
description: 35 pages, 10 figures
The Likoma network study: study context, data collection and survey instruments
Creators: name: Helleringer, Stephane
name: Chimbiri, Agnes
name: Mkandawire, James
name: Kohler, Hans-Peter
name: Chatonda, Praise
Publisher: name: Columbia University
Year: 2009
Subjects: Epidemiology
Medical sciences

description: The extent and structure of sexual networks have important consequences for the spread of sexually transmitted diseases such as HIV. However, very few datasets currently exist that allow a detailed investigation of sexual networks in sub-Saharan African settings where HIV epidemics have become generalized. In this paper, we describe the context and methods of the Likoma Network Study (LNS), one of the few studies that have collected extensive information on sexual networks in sub-Saharan Africa. We start by reviewing theoretical arguments and empirical studies emphasizing the importance of network structures in the epidemiology of HIV and other sexually transmitted infections (STI). The island setting of this study is described, and we argue that the choice of an island as a research site limited potential biases that may make the collection of sexual network data difficult. We then document our empirical strategy for the collection of sexual network data and the subsequent identification of sexual network partners. A description of the protocol for the collection of biomarker data (HIV infection) is provided. Finally, we present initial results relating to the socioeconomic context of the island, the size and composition of sexual networks, the quality of the sexual network data, the determinants of successful contact tracing during the LNS, and the prevalence of HIV in the study population.
First direct limit on the 334 keV resonance strength in the $^{22}$Ne(α,γ)$^{26}$Mg reaction
Creators: name: Piatti, D.
name: Masha, E.
name: Aliotta, M.
name: Balibrea-Correa, J.
name: Barile, F.
name: Bemmerer, D.
name: Best, A.
name: Boeltzig, A.
name: Broggini, C.
name: Bruno, C. G.
name: Caciolli, A.
name: Cavanna, F.
name: Chillery, T.
name: Ciani, G. F.
name: Compagnucci, A.
name: Corvisiero, P.
name: Csedreki, L.
name: Davinson, T.
name: Depalo, R.
name: di Leva, A.
name: Elekes, Z.
name: Ferraro, F.
name: Fiore, E. M.
name: Formicola, A.
name: Fülöp, Zs.
name: Gervino, G.
name: Guglielmetti, A.
name: Gustavino, C.
name: Gyürky, Gy.
name: Imbriani, G.
name: Junker, M.
name: Lugaro, M.
name: Marigo, P.
name: Menegazzo, R.
name: Mossa, V.
name: Pantaleo, F. R.
name: Paticchio, V.
name: Perrino, R.
name: Prati, P.
name: Rapagnani, D.
name: Schiavulli, L.
name: Skowronski, J.
name: Stöckel, K.
name: Straniero, O.
name: Szücs, T.
name: Takács, M. P.
name: Zavatarelli, S.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: In stars, the fusion of $^{22}$Ne and $^4$He may produce either $^{25}$Mg, with the emission of a neutron, or $^{26}$Mg and a $γ$ ray. At high temperature, the ($α,n$) channel dominates, while at low temperature, it is energetically hampered. The rate of its competitor, the $^{22}$Ne($α$,$γ$)$^{26}$Mg reaction, and, hence, the minimum temperature for the ($α,n$) dominance, are controlled by many nuclear resonances. The strengths of these resonances have hitherto been studied only indirectly. The present work aims to directly measure the total strength of the resonance at $E$_{r}$\,=\,$334$\,$keV (corresponding to $E$_{x}$\,=\,$10949$\,$keV in $^{26}$Mg). The data reported here have been obtained using high intensity $^4$He$^+$ beam from the INFN LUNA 400 kV underground accelerator, a windowless, recirculating, 99.9% isotopically enriched $^{22}$Ne gas target, and a 4$π$ bismuth germanate summing $γ$-ray detector. The ultra-low background rate of less than 0.5 counts/day was determined using 67 days of no-beam data and 7 days of $^4$He$^+$ beam on an inert argon target. The new high-sensitivity setup allowed to determine the first direct upper limit of 4.0$\,\times\,$10$^{-11}$ eV (at 90% confidence level) for the resonance strength. Finally, the sensitivity of this setup paves the way to study further $^{22}$Ne($α$,$γ$)$^{26}$Mg resonances at higher energy.
description: Submitted to Eur. Phys. J. A
Two new bioactive lignans from leaves and twigs of Cleistanthus concinnus Croizat
Creators: name: Fan, Shi-Rui
name: Guo, Jing-Jing
name: Wang, Yi-Ting
name: Yang, Bi-Juan
name: Duo-Zhi Chen
name: Hao, Xiao-Jiang
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: Two new lignans (1–2), along with five known compounds (3-7) with different structures were isolated from leaves and twigs of Cleistanthus concinnus Croizat. The new lignans were elucidated as (7′R,8′S)-3,3′,5′-trimethoxy-4,4′-dihydroxy-7-en-7′,9- epoxy-8,8′-lignan (1) and (7′R,8′S)-3,3′-dimethoxy-4,4′-dihydroxy-7-en-7′,9-epoxy-8, 8′-lignan (2) by comprehensive spectroscopic analysis including 1D and 2D NMR as well as HREIMS and comparing their NMR data with known compounds in the literature. Among these isolated compounds, compound 1, 2, 3, and 6 were tested for anti- inflammatory effects by inhibiting NO production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Compound 1, 2, and 6 exhibit NO inhibitory activity.
Assembly and Installation of the Daya Bay Antineutrino Detectors
Creators: name: Band, H. R.
name: Brown, R. L.
name: Carr, R.
name: Chen, X. C.
name: Chen, X. H.
name: Cherwinka, J. J.
name: Chu, M. C.
name: Draeger, E.
name: Dwyer, D. A.
name: Edwards, W. R.
name: Gill, R.
name: Goett, J.
name: Greenler, L. S.
name: Gu, W. Q.
name: He, W. S.
name: Heeger, K. M.
name: Heng, Y. K.
name: Hinrichs, P.
name: Ho, T. H.
name: Hoff, M.
name: Hsiung, Y. B.
name: Jin, Y.
name: Kang, L.
name: Kettell, S. H.
name: Kramer, M.
name: Kwan, K. K.
name: Kwok, M. W.
name: Lewis, C. A.
name: Li, G. S.
name: Li, N.
name: Li, S. F.
name: Li, X. N.
name: Lin, C. J.
name: Littlejohn, B. R.
name: Liu, J. L.
name: Luk, K. B.
name: Luo, X. L.
name: Ma, X. Y.
name: McFarlane, M. C.
name: McKeown, R. D.
name: Nakajima, Y.
name: Ochoa-Ricoux, J. P.
name: Pagac, A.
name: Qian, X.
name: Seilhan, B.
name: Shih, K.
name: Steiner, H.
name: Tang, X.
name: Themann, H.
name: Tsang, K. V.
name: Tsang, R. H. M.
name: Virostek, S.
name: Wang, L.
name: Wang, W.
name: Wang, Z. M.
name: Webber, D. M.
name: Wei, Y. D.
name: Wen, L. J.
name: Wenman, D. L.
name: Wilhelmi, J.
name: Wingert, M.
name: Wise, T.
name: Wong, H. L. H.
name: Wu, F. F.
name: Xiao, Q.
name: Yang, L.
name: Zhang, Z. J.
name: Zhong, W. L.
name: Zhuang, H. L.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The Daya Bay reactor antineutrino experiment is designed to make a precision measurement of the neutrino mixing angle theta13, and recently made the definitive discovery of its nonzero value. It utilizes a set of eight, functionally identical antineutrino detectors to measure the reactor flux and spectrum at baselines of 300 - 2000m from the Daya Bay and Ling Ao Nuclear Power Plants. The Daya Bay antineutrino detectors were built in an above-ground facility and deployed side-by-side at three underground experimental sites near and far from the nuclear reactors. This configuration allows the experiment to make a precision measurement of reactor antineutrino disappearance over km-long baselines and reduces relative systematic uncertainties between detectors and nuclear reactors. This paper describes the assembly and installation of the Daya Bay antineutrino detectors.
description: 31 pages, 19 figures
Violacein antimicrobial activity on Staphylococcus epidermidis biofilm
Creators: name: H. V. Dodou
name: A. H. M. Batista
name: S. C. Medeiros
name: G. W. P. Sales
name: M. L. Rodrigues
name: P. I. O. Pereira
name: P. C. N. Nogueira
name: E. R. Silveira
name: T. B. Grangeiro
name: N. A. P. Nogueira
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: The aim of this study was to evaluate the antimicrobial potential of violacein (VIO) on Staphylococcus epidermidis biofilm. The minimum biofilm inhibition concentration (MBIC) and minimum biofilm eradication concentration (MBEC) were determined, as well as the effect of VIO exposure time on microbial viability in mature biofilm. Violacein showed good antibiofilm action, inhibiting biofilm formation and eradicating mature biofilm of S. epidermidis at concentrations of 20 μg.mL−1 and 160 μg.mL−1, respectively. At concentrations equal to MBEC and 2x MBEC, the biofilm was eradicated in 3 h and 2h30min of incubation, respectively.When evaluating VIO modulating effect on the action of clinically-used drugs (vancomycin, cefepime, ciprofloxacin and meropenem), especial synergism was observed in the violacein-ciprofloxacin association, it can completely erradicated the mature biofilm at the concentration of 1/2xMBEC and 1/4xMBEC, respectively. VIO shows good antimicrobial action on S. epidermidis biofilm and has the potential to synergistically modulate the activity of clinically-used antimicrobials.
Powering Europe with North Sea Offshore Wind: The Impact of Hydrogen Investments on Grid Infrastructure and Power Prices
Creators: name: Durakovic, Goran
name: del Granado, Pedro Crespo
name: Tomasgard, Asgeir
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Economics (econ.GN)
subject: Optimization and Control (math.OC)
subject: FOS: Economics and business
subject: FOS: Mathematics

description: Hydrogen will be a central cross-sectoral energy carrier in the decarbonization of the European energy system. This paper investigates how a large-scale deployment of green hydrogen production affects the investments in transmission and generation towards 2060, analyzes the North Sea area with the main offshore wind projects, and assesses the development of an offshore energy hub. Results indicate that the hydrogen deployment has a tremendous impact on the grid development in Europe and in the North Sea. Findings indicate that total power generation capacity increases around 50%. The offshore energy hub acts mainly as a power transmission asset, leads to a reduction in total generation capacity, and is central to unlock the offshore wind potential in the North Sea. The effect of hydrogen deployment on power prices is multifaceted. In regions where power prices have typically been lower than elsewhere in Europe, it is observed that hydrogen increases the power price considerably. However, as hydrogen flexibility relieves stress in high-demand periods for the grid, power prices decrease in average for some countries. This suggests that while the deployment of green hydrogen will lead to a significant increase in power demand, power prices will not necessarily experience a large increase.
description: Submitted to Energy
title: Analyse de l'Utilisation des Outils de Gestion Comptable par les Entreprises du Secteur Informel au Congo
title: Analyse de l'Utilisation des Outils de Gestion Comptable par les Entreprises du Secteur Informel au Congo
titleType: Other
Creators: name: GNANGA, Gildas Walter
Publisher: name: Zenodo
Year: 2023

description: Le secteur informel au Congo joue un rôle important dans l'économie, contribuant à la création d'emplois et de revenus " (Yakoubou & al., 2021). Cependant, en raison de son caractère informel, Il fait face à des défis majeurs de gestion, notamment dans l'utilisation des outils de gestion comptables (Berrou & Eekhout, T .2019). Cette recherche vise à approfondir la compréhension de l'utilisation des outils de gestion comptable par les entreprises du secteur informel au Congo.
Further remarks on the "Smith is Huq" condition
Creators: name: Martins-Ferreira, Nelson
name: Van der Linden, Tim
Publisher: name: arXiv
Year: 2014
Subjects: subject: Category Theory (math.CT)
subject: FOS: Mathematics
subject: 18D35, 18E10, 08A30, 20J15

description: We compare the 'Smith is Huq' condition (SH) with three commutator conditions in semi-abelian categories: first an apparently weaker condition which arose in joint work with Bourn and turns out to be equivalent with (SH), then an apparently equivalent condition which takes commutation of non-normal subobjects into account and turns out to be stronger than (SH). This leads to the even stronger condition that weighted commutators (in the sense of Gran, Janelidze and Ursini) are independent of the chosen weight, which is known to be false for groups but turns out to be true in any two-nilpotent semi-abelian category.
description: 13 pages
Avoiding approximate repetitions with respect to the longest common subsequence distance
Creators: name: Camungol, Serina
name: Rampersad, Narad
Publisher: name: arXiv
Year: 2013
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 68R15

description: Ochem, Rampersad, and Shallit gave various examples of infinite words avoiding what they called approximate repetitions. An approximate repetition is a factor of the form xx', where x and x' are close to being identical. In their work, they measured the similarity of x and x' using either the Hamming distance or the edit distance. In this paper, we show the existence of words avoiding approximate repetitions, where the measure of similarity between adjacent factors is based on the length of the longest common subsequence. Our principal technique is the so-called "entropy compression" method, which has its origins in Moser and Tardos's algorithmic version of the Lovasz local lemma.
Spatio-temporal Keyframe Control of Traffic Simulation using Coarse-to-Fine Optimization
Creators: name: Han, Yi
name: Wang, He
name: Jin, Xiaogang
Publisher: name: arXiv
Year: 2022
Subjects: subject: Graphics (cs.GR)
subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: We present a novel traffic trajectory editing method which uses spatio-temporal keyframes to control vehicles during the simulation to generate desired traffic trajectories. By taking self-motivation, path following and collision avoidance into account, the proposed force-based traffic simulation framework updates vehicle's motions in both the Frenet coordinates and the Cartesian coordinates. With the way-points from users, lane-level navigation can be generated by reference path planning. With a given keyframe, the coarse-to-fine optimization is proposed to efficiently generate the plausible trajectory which can satisfy the spatio-temporal constraints. At first, a directed state-time graph constructed along the reference path is used to search for a coarse-grained trajectory by mapping the keyframe as the goal. Then, using the information extracted from the coarse trajectory as initialization, adjoint-based optimization is applied to generate a finer trajectory with smooth motions based on our force-based simulation. We validate our method with extensive experiments.
Syringic acid (4-hydroxy-3,5-dimethoxybenzoic acid) inhibits adipogenesis and promotes lipolysis in 3T3-L1 adipocytes
Creators: name: John, Cordelia Mano
name: Arockiasamy, Sumathy
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Increase in adiposity is associated with obesity and obesity-related complications. Syringic acid (SA), a phenolic acid facilitates oxidation, polymerization, and condensation reactions, may function as an effective anti-adipogenic agent. This study examined whether SA inhibits adipogenesis in 3T3-L1 preadipocytes by inhibiting differentiation and controlling lipid accumulation. Ten days of SA treatment suppressed differentiation of 3T3-L1 preadipocyte to mature adipocytes in a concentration-dependent manner as determined by Oil Red O staining. Suppression of adipogenic differentiation by SA was primarily from inhibition of mitotic clonal expansion during the early stages of differentiation. Treatment of adipocytes with SA reduced triglyceride production (lipogenesis) and increased glycerol release (lipolysis). The addition of SA to the adipocytes attenuated in vitro ROS production. These results indicate that SA inhibits the adipogenesis of 3T3-L1 preadipocytes, reduces lipid accumulation, and attenuates ROS accumulation, suggesting for the first time that SA has an anti-obesity effect in vitro.
α-Glucosidase and glycation inhibitory activities of Rumex lunaria leaf extract: a promising plant against hyperglycaemia-related damage
Creators: name: Froldi, Guglielmina
name: González, Diana Luján
name: Rosteghin, Francesca
name: Grison, Margherita
name: Sut, Stefania
name: Dall’Acqua, Stefano
name: Sánchez-Mateo, Candelaria Del Carmen
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Plant Biology

description: Rumex lunaria L. is a Canarian medicinal plant, belonging to Polygonaceae. The potential antidiabetic activity of the methanolic extract of the leaves was investigated. For this purpose, the inhibition of α-glucosidase and albumin glycation by the extract was studied. Further, the anti-radical activity and the phytochemical composition were detected. The reduction of α-glucosidase activity was significant from 3 µg/mL, while the BSA glycation inhibition started from 100 µg/mL. Moreover, the extract exhibited a significant free-radical scavenger activity. Its phytochemical characterization showed the presence of carotenoids, phenolic and flavonoid compounds, whereas anthraquinones were not detected. C-flavonoid glycosides were identified and quercetin-O-hexoside-O-deoxyhexoside was the most detected (22.67 ± 0.02 mg/g). The findings indicate that the methanolic R. lunaria leaf extract has significant anti-α-glucosidase, anti-radical and anti-glycation activities. This research is the first showing the potential antidiabetic activity of R. lunaria.
Lotka-Volterra Models for Extraterrestrial Self-Replicating Probes
Creators: name: Chen, Yifan
name: Ni, Jiayi
name: Ong, Yen Chin
Publisher: name: arXiv
Year: 2022
Subjects: subject: Dynamical Systems (math.DS)
subject: Popular Physics (physics.pop-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: A sufficiently advanced extraterrestrial civilization can send out a swarm of self-replicating probes for space exploration. Given the fast-growing number of such a probe, even if there is only one extraterrestrial civilization sending out such probes in the Milky Way galaxy, we should still expect to see them. The fact that we do not consists part of the Fermi paradox. The suggestion that self-replicating probes will eventually mutate to consume their progenitors and therefore significantly reduce the number of total probes has been investigated and dismissed in the literature. In this work, we re-visit this question with a more realistic Lotka-Volterra model, and show that mutated probes would drive the progenitor probes into "extinction", thereby replacing them to spread throughout the galaxy. Thus, the efficiency of mutated probes in reducing the total number of self-replicating probes is even less than previously thought. As part of the analysis, we also suggest that, somewhat counter-intuitively, in designing self-replicating probes, one should not program them to stop replicating when sufficient mutation causes the probes to fail to recognize the progenitor probes as "self".
description: Revised version to appear in EPJ Plus
In vitro bioassay guided anti-dermatophyte and cytotoxic activities from Piper umbellatum L. Miq. led to 4-nerolidylcatechol
Creators: name: Jolindo A. Freitas
name: Sorrechia, Rodrigo
name: Politi, Flávio A. S.
name: Santos, André G.
name: Edvânio R. Rodrigues
name: Santos, Lourdes C.
name: Fusco-Almeida, Ana M.
name: Oliveira, Andrew A.
name: Guido, Rafael V. C.
name: Rosemeire C. L. R. Pietro
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Dermatophytosis is a dermic disease caused by fungi. The aim of this study was to search anti-dermatophyte bioactive compounds in Piper umbellatum leaves. Cytotoxicity evaluation was performed against MRC-5 and HepG2 as a selectivity parameter. Crude ethanol extract presented MIC value of 39.1 μg/mL against M. canis and no cytotoxicity to Hep G2 (human liver cancer) and MRC-5 (normal lung fibroblast). 4-nerolydilcatechol was isolated from P. umbellatum ethanolic extract. MIC values for 4-NC were 7.6μM to M. canisand 15.6μM to Trichophyton rubrum. 4-NC presented activity against M. canis14 times lower than to MRC-5 (non-tumoral human cell line), which suggest selective activity for this fungus. Molecular modeling suggests 4-NC could bind to CYP51, present in lanosterol synthesis, blocking fungi development. In conclusion, P. umbellatum crude ethanol extract and 4-NC demonstrated high and selective in vitro antifungal activity.
Northern Nigeria Maternal, Newborn and Child Health Programme: Selected Analyses from Population-Based Baseline Survey
Creators: name: Helleringer, Stephane
name: Doctor, Henry V.
name: Bairagi, Radheshyam
name: Findley, Sally E.
name: Dahiru, Tukur
Publisher: name: Columbia University
Year: 2011
Subjects: Public health

description: Maternal mortality in Northern Nigeria is among the highest in the world. To guide programme planning we interviewed 7,442 women in April and May 2009 in three northern states (Katsina, Yobe, and Zamfara) to understand patterns of antenatal care and delivery. Here, we present findings from a population-based survey conducted under the PRRINN-MNCH Programme to provide evidence-base programmatic interventions aimed at improving maternal and child health indicators. In the paper, we outline the health challenges facing northern Nigeria, describe the PRRINN-MNCH Programme, describe the baseline survey design, implementation, and subsequent data. We provide a series of maternal and child health indicators in order to address two key important policy issues: (1) the importance of visits to health care facilities to enable women get proper maternal care, and (2) the importance of having access to skilled personnel at birth. We further describe how these data can be used to develop appropriate strategies for integrated programmes to increase awareness of pregnancy and delivery complications and to reduce the barriers to assessing risk and accessing the facilities in a timely manner. Appropriate strategies and interventions are necessary to address the existing health challenges. To a large extent, these data also provide an opportunity to measure the impact of the programme in assisting Nigeria attain the health Millennium Development Goals of maternal and child health.
Antibacterial activity of the lichens Usnea Florida and Flavoparmelia caperata (Parmeliaceae)
Creators: name: Dieu, Amandine
name: Lengo Mambu
name: Champavier, Yves
name: Chaleix, Vincent
name: Sol, Vincent
name: Gloaguen, Vincent
name: Millot, Marion
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Acetone extracts of the two common epiphytes lichens Usnea florida and Flavoparmelia caperata have been evaluated for their antimicrobial activities against Staphylococcus aureus, Candida albicans and Aspergillus brasiliensis. The dibenzofuran derivative (+)-usnic acid (1) was the main metabolite in these two species. Thamnolic (5), evernic (6), physodic (7) and 3-hydroxyphysodic acids (8) were isolated from U. florida, as well as 5,7-dihydroxy-6-methylphtalide (2) which was newly identified in this Genus. Protocetraric (3) and caperatic acids (4) and ergosterol peroxide (9) are usually biosynthezised by F. caperata. Antibacterial activity was determined for the four main compounds against Staphylococcus aureus using bioautography and broth dilution method. Minimal inhibitory concentrations of usnic acid, caperatic acid and protocetraric acid were comprised between 7.25 and 12.5 µg/mL.
GtoPdb Database Progress Report - April 2023
Creators: name: Simon D Harding
name: Elena Faccenda
name: Jane F Armstrong
Publisher: name: Zenodo
Year: 2023
Subjects: pharmacology
database

description: Presentation made at the NC-IUPHAR Database Meeting in Paris, 20th-21st April 2023. Giving an update on the Guide to Pharmacology database progress
Revisiting the composition dependence of the properties of water-dimethyl sulfoxide liquid mixtures. Molecular dynamics computer simulations
Creators: name: Aguilar, M.
name: Dominguez, H.
name: Pizio, O.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We have revisited the composition dependence of principal properties of liquid water-DMSO mixtures by using the isobaric-isothermal molecular dynamics computer simulations. A set of non-polarizable semi-flexible models for the DMSO molecule combined with the TIP4P-2005 and TIP4P/$\varepsilon$ water models is considered. We restrict calculations to atmospheric pressure, 0.1013 MPa, and room temperature, 298.15 K. Composition trends of density, excess mixing volume and excess mixing enthalpy, partial molar volumes and partial molar enthalpies of species, apparent molar volumes are reported. Besides, we explore composition trends of the self-diffusion of species, the static dielectric constant and the surface tension. Evolution of the microscopic structure of the mixture with composition is analyzed in terms of radial distributions functions, coordination numbers and the fractions of hydrogen-bonded molecules. We intend to capture the peculiarities of mixing the species in the mixture upon the DMSO molar fraction and the anomalous behaviors, if manifested in each of the properties under study. The quality of several combinations of the models for species is evaluated in detail to establish the possibility of necessary improvements.
description: 19 pages, 11 figures, 1 table
The active fraction from the tuber of Bolboschoenus yagara inhibits melanoma B16 cells metastasis LPS-induced in vitro and in vivo
Creators: name: Cao, Qing-Yun
name: Guo, Xing-Yu
name: Jin-Ao Duan
name: Liang, Qiao-Li
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: This study was to identify anti-metastatic active fractions and compounds of Bolboschoenus yagara (B. yagara). The results indicated that 50 µg/mL ethyl acetate fraction (Et) can dramatically inhibit mouse melanoma B16 cells migration and invasion in vitro. In B16 cells pulmonary and hepatic metastasis assays, 50 µg/mL Et alleviated mouse lung and liver weights, the number of metastatic nodules and the levels of TNF-α and IL-6 in mouse serum and organs. Histological studies showed that Et fraction was able to prevent liver and lung metastasis. And the inhibition of 50 µg/mL Et fraction against hepatic metastasis was almost equivalent to that of 1 µM TAK242. In addition, fourteen compounds of Et were quantified by HPLC analysis, in which, isocoumarins, stilbenes and xanthones obviously abated LPS-modulated B16 cells migration and invasion.
NGTS-21b: An Inflated Super-Jupiter Orbiting a Metal-poor K dwarf
Creators: name: Alves, Douglas R.
name: Jenkins, James S.
name: Vines, Jose I.
name: Nielsen, Louise D.
name: Gill, Samuel
name: Acton, Jack S.
name: Anderson, D. R.
name: Bayliss, Daniel
name: Bouchy, François
name: Breytenbach, Hannes
name: Bryant, Edward M.
name: Burleigh, Matthew R.
name: Casewell, Sarah L.
name: Eigmüller, Philipp
name: Gillen, Edward
name: Goad, Michael R.
name: Günther, Maximilian N.
name: Henderson, Beth A.
name: Kendall, Alicia
name: Lendl, Monika
name: Moyano, Maximiliano
name: Sefako, Ramotholo R.
name: Smith, Alexis M. S.
name: Costes, Jean C.
name: Tilbrook, Rosanne H.
name: Thomas, Jessymol K.
name: Udry, Stéphane
name: Watson, Christopher A.
name: West, Richard G.
name: Wheatley, Peter J.
name: Worters, Hannah L.
name: Osborn, Ares
Publisher: name: arXiv
Year: 2022
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We report the discovery of NGTS-21b, a massive hot Jupiter orbiting a low-mass star as part of the Next Generation Transit Survey (NGTS). The planet has a mass and radius of $2.36 \pm 0.21$ M$_{\rm J}$, and $1.33 \pm 0.03$ R$_{\rm J}$, and an orbital period of 1.543 days. The host is a K3V ($T_{\rm eff}=4660 \pm 41$, K) metal-poor (${\rm [Fe/H]}=-0.26 \pm 0.07$, dex) dwarf star with a mass and radius of $0.72 \pm 0.04$, M$_{\odot}$,and $0.86 \pm 0.04$, R$_{\odot}$. Its age and rotation period of $10.02^{+3.29}_{-7.30}$, Gyr and $17.88 \pm 0.08$, d respectively, are in accordance with the observed moderately low stellar activity level. When comparing NGTS-21b with currently known transiting hot Jupiters with similar equilibrium temperatures, it is found to have one of the largest measured radii despite its large mass. Inflation-free planetary structure models suggest the planet's atmosphere is inflated by $\sim21\%$, while inflationary models predict a radius consistent with observations, thus pointing to stellar irradiation as the probable origin of NGTS-21b's radius inflation. Additionally, NGTS-21b's bulk density ($1.25 \pm 0.15$, g/cm$^3$) is also amongst the largest within the population of metal-poor giant hosts ([Fe/H] < 0.0), helping to reveal a falling upper boundary in metallicity-planet density parameter space that is in concordance with core accretion formation models. The discovery of rare planetary systems such as NGTS-21 greatly contributes towards better constraints being placed on the formation and evolution mechanisms of massive planets orbiting low-mass stars.
description: 12 pages, 13 figures, accepted for publication in MNRAS
Electroweak phase transition in the reduced minimal 3-3-1 model
Creators: name: Phong, Vo Quoc
name: Long, Hoang Ngoc
name: Van, Vo Thanh
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The electroweak phase transition is considered in framework of the reduced minimal 3-3-1 model (RM331). Structure of phase transition in this model is divided into two periods. The first period is the phase transition SU(3) ---> SU(2) at TeV scale and the second one is SU(2)--> U(1), which is the like-Standard Model electroweak phase transition. When mass of the neutral Higgs boson (h_1) is taken to be equal to the LHC value: m_{h_1}=125 GeV, then these phase transitions are the first order phase transitions, the mass of Z_2 is about 4.8 TeV; and we find the region of parameter space with the first order phase transition at v_{ρ_0}=246 GeV scale, leading to an effective potential, where mass of the charged Higgs boson is in range of 4.154 TeV < m_{h_{++}} < 5.946 TeV. Therefore, with this approach, new bosons are the triggers of the first order electroweak phase transition with significant implications for the viability of electroweak baryogenesis scenarios.
description: 21 pages, 3 figures
Two new alkaloids from the tubers of Corydalis ambigua subsp. amurensis and their anti-proliferative activity
Creators: name: Zhihui Liu
name: Zhenru Mi
name: Panpan Wang
name: Chang, Sheng
name: Han, Na
name: Yin, Jun
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Two new alkaloids, including one benzophenanthridine type, dehydroambiguanine A (1) and one isoquinoline type, ambiguanine J (2) together with four (3–6) known alkaloids were isolated from the n-butanol fraction of Corydalis ambigua subsp. amurensis. Their structures were elucidated by comprehensive spectroscopic methods including HR-ESIMS and NMR, and the absolute configuration of compound 1 was further confirmed by the quantum ECD calculations. In addition, all isolated alkaloids (1–6) were determined their anti-proliferative effects of on A549 and HCT 116 cell by colorimetric MTT assay. Among them, Compounds 1 and 4 exhibited anti-proliferative activity on HCT 116 cell line with the IC50 value at 49.8 ± 4.79, and 89.2 ± 1.86 μM, respectively. Compounds 2 and 5 showed mild anti-proliferative activity against A549 cell with IC50 values at 60.2 ± 10.7, and 89.2 ± 12.9 μM, respectively. Their preliminary structure-activity relationship was also discussed.
Equalizing Credit Opportunity in Algorithms: Aligning Algorithmic Fairness Research with U.S. Fair Lending Regulation
Creators: name: Kumar, I. Elizabeth
name: Hines, Keegan E.
name: Dickerson, John P.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Machine Learning (cs.LG)
subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences

description: Credit is an essential component of financial wellbeing in America, and unequal access to it is a large factor in the economic disparities between demographic groups that exist today. Today, machine learning algorithms, sometimes trained on alternative data, are increasingly being used to determine access to credit, yet research has shown that machine learning can encode many different versions of "unfairness," thus raising the concern that banks and other financial institutions could -- potentially unwittingly -- engage in illegal discrimination through the use of this technology. In the US, there are laws in place to make sure discrimination does not happen in lending and agencies charged with enforcing them. However, conversations around fair credit models in computer science and in policy are often misaligned: fair machine learning research often lacks legal and practical considerations specific to existing fair lending policy, and regulators have yet to issue new guidance on how, if at all, credit risk models should be utilizing practices and techniques from the research community. This paper aims to better align these sides of the conversation. We describe the current state of credit discrimination regulation in the United States, contextualize results from fair ML research to identify the specific fairness concerns raised by the use of machine learning in lending, and discuss regulatory opportunities to address these concerns.