title: Ð¡ÑÐ¿ÑÐ°Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½ÑÐµ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÑ Ð°Ð½ÑÑÐ°ÑÐ¸ÐºÐ»Ð¸Ð½Ð¾Ð²Ð¾Ð³Ð¾ Ð°Ð½ÑÐ¸Ð±Ð¸Ð¾ÑÐ¸ÐºÐ° Ð´Ð¾ÐºÑÐ¾ÑÑÐ±Ð¸ÑÐ¸Ð½Ð° Ñ Ð¿Ð¾Ð»Ð¸Ð²Ð¸Ð½Ð¸Ð»Ð¿Ð¸ÑÑÐ¾Ð»Ð¸Ð´Ð¾Ð½Ð¾Ð¼ Ð¸ Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸ÑÐ°Ð¼Ð¸ ÑÐµÐ»ÐµÐ½Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Supramolecular complexes of the anthracycline antibiotic doxorubicin with polyvinylpyrrolidone and selenium nanoparticles
Creators: name: Ð¯ÐºÐ¾Ð²Ð»ÐµÐ², ÐÐ»ÑÑ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: Ð³Ð¸Ð±ÑÐ¸Ð´Ð½ÑÐµ Ð¾ÑÐ³Ð°Ð½Ð¾-Ð½ÐµÐ¾ÑÐ³Ð°Ð½Ð¸ÑÐµÑÐºÐ¸Ðµ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÑ
Ð¼ÐµÐ¶Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½ÑÐµ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ
Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸ÑÑ
ÑÐµÐ»ÐµÐ½
ÑÑÐ°Ð±Ð¸Ð»Ð¸Ð·Ð°ÑÐ¸Ñ Ð² Ð¼Ð½Ð¾Ð³Ð¾ÐºÐ¾Ð¼Ð¿Ð¾Ð½ÐµÐ½ÑÐ½Ð¾Ð¹ ÑÐ¼ÐµÑÐ¸
Ð°Ð½ÑÑÐ°ÑÐ¸ÐºÐ»Ð¸Ð½Ð¾Ð²ÑÐµ Ð°Ð½ÑÐ¸Ð±Ð¸Ð¾ÑÐ¸ÐºÐ¸
Ð¿Ð¾Ð»Ð¸Ð²Ð¸Ð½Ð¸Ð»Ð¿Ð¸ÑÑÐ¾Ð»Ð¸Ð´Ð¾Ð½
ÑÐ¿ÐµÐºÑÑÐ¾ÑÐ¾ÑÐ¾Ð¼ÐµÑÑÐ¸Ñ
ÑÐ¸ÑÑÐ¾Ð²Ð°ÐµÐ½Ð¸Ðµ
Ð¸Ð·Ð¾Ð¼Ð¾Ð»ÑÑÐ½ÑÐµ ÑÐµÑÐ¸Ð¸
Ð´Ð¸Ð½Ð°Ð¼Ð¸ÑÐµÑÐºÐ¾Ðµ ÑÐ²ÐµÑÐ¾ÑÐ°ÑÑÐµÑÐ½Ð¸Ðµ
hybrid organic-inorganic composites
intermolecular interactions
nanoparticles
selenium
stabilization in a multicomponent mixture
anthracycline antibiotics
polyvinylpyrrolidone
spectrophotometry
titration
isomolar series
dynamic light scattering

description: Ð ÑÐ°Ð±Ð¾ÑÐµ Ð±ÑÐ»Ð¸ Ð¸Ð·ÑÑÐµÐ½Ñ Ð¿ÑÐ¾ÑÐµÑÑÑ ÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¸ ÑÑÐ°Ð±Ð¸Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸Ñ ÑÐµÐ»ÐµÐ½Ð° Ð² Ð¿ÑÐ¸ÑÑÑÑÑÐ²Ð¸Ð¸ Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð¾Ð¿ÑÑÐ¾Ð»ÐµÐ²Ð¾Ð³Ð¾ Ð°Ð½ÑÐ¸Ð±Ð¸Ð¾ÑÐ¸ÐºÐ° Ð´Ð¾ÐºÑÐ¾ÑÑÐ±Ð¸ÑÐ¸Ð½Ð° Ð¸ Ð¿Ð¾Ð»Ð¸Ð²Ð¸Ð½Ð¸Ð»Ð¿Ð¸ÑÑÐ¾Ð»Ð¸Ð´Ð¾Ð½Ð°. ÐÑÐ»Ð¾ ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð¾, ÑÑÐ¾ Ð´Ð¾ÐºÑÐ¾ÑÑÐ±Ð¸ÑÐ¸Ð½ Ð½Ðµ ÑÑÐ°Ð±Ð¸Ð»Ð¸Ð·Ð¸ÑÑÐµÑ Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸ÑÑ ÑÐµÐ»ÐµÐ½Ð°. ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ° Ð´Ð¾ÐºÑÐ¾ÑÑÐ±Ð¸ÑÐ¸Ð½Ð° Ñ Ð¿Ð¾Ð»Ð¸Ð²Ð¸Ð½Ð¸Ð»Ð¿Ð¸ÑÑÐ¾Ð»Ð¸Ð´Ð¾Ð½Ð¾Ð¼ Ð¼ÐµÑÐ¾Ð´Ð¾Ð¼ ÑÐ¿ÐµÐºÑÑÐ¾ÑÐ¾ÑÐ¾Ð¼ÐµÑÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐ¸ÑÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¸ Ð¼ÐµÑÐ¾Ð´Ð¾Ð¼ Ð¼Ð¾Ð´Ð¸ÑÐ¸ÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÑ Ð¸Ð·Ð¾Ð¼Ð¾Ð»ÑÑÐ½ÑÑ ÑÐµÑÐ¸Ð¹, Ð¿Ð¾ÐºÐ°Ð·Ð°Ð»Ð¾, ÑÑÐ¾ Ð½Ð°Ð¸Ð±Ð¾Ð»ÐµÐµ Â«ÑÐ¸Ð»ÑÐ½ÑÐµÂ» Ð¼ÐµÐ¶Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½ÑÐµ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð¾ÑÑÑÐµÑÑÐ²Ð»ÑÑÑÑÑ Ð¿Ð¾ Ð³Ð¸Ð´ÑÐ¾ÑÐ¾Ð±Ð½Ð¾Ð¼Ñ ÑÑÐ°Ð³Ð¼ÐµÐ½ÑÑ Ð´Ð¾ÐºÑÐ¾ÑÑÐ±Ð¸ÑÐ¸Ð½Ð°. ÐÐ²ÑÐ¼Ñ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð½ÑÐ¼Ð¸ Ð¼ÐµÑÐ¾Ð´Ð°Ð¼Ð¸ Ð±ÑÐ»Ð¸ ÑÐ¸Ð½ÑÐµÐ·Ð¸ÑÐ¾Ð²Ð°Ð½Ñ ÑÑÐ¾Ð¹Ð½ÑÐµ Ð½Ð°Ð½Ð¾ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÑ Â«Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸ÑÑ ÑÐµÐ»ÐµÐ½Ð° â Ð¿Ð¾Ð»Ð¸Ð²Ð¸Ð½Ð¸Ð»Ð¿Ð¸ÑÑÐ¾Ð»Ð¸Ð´Ð¾Ð½ â Ð´Ð¾ÐºÑÐ¾ÑÑÐ±Ð¸ÑÐ¸Ð½Â». ÐÑÐ»Ð¾ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¾ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Ð¼ÐµÑÐ¾Ð´Ð° ÑÐ¸Ð½ÑÐµÐ·Ð° Ð½Ð° ÑÐ¿ÐµÐºÑÑÐ°Ð»ÑÐ½ÑÐµ Ð¸ ÑÐ°Ð·Ð¼ÐµÑÐ½ÑÐµ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸ÐºÐ¸ ÑÑÐ¾Ð¹Ð½ÑÑ Ð½Ð°Ð½Ð¾ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ¾Ð². ÐÐ¾ÐºÐ°Ð·Ð°Ð½Ð¾, ÑÑÐ¾ Ð¿ÑÐ¸Ð¼ÐµÐ½ÑÐµÐ¼ÑÐµ Ð¼ÐµÑÐ¾Ð´Ñ ÑÐ¸Ð½ÑÐµÐ·Ð° Ð¿Ð¾Ð·Ð²Ð¾Ð»ÑÑÑ Ð¿Ð¾Ð»ÑÑÐ°ÑÑ ÑÑÐ°Ð±Ð¸Ð»ÑÐ½ÑÐµ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÑ, ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸Ð·ÑÑÑÐ¸ÐµÑÑ ÑÐ½Ð¸Ð¼Ð¾Ð´Ð°Ð»ÑÐ½ÑÐ¼ ÑÐ°ÑÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸ÐµÐ¼ Ð¿Ð¾ ÑÐ°Ð·Ð¼ÐµÑÐ°Ð¼. Ð£ÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð¾, ÑÑÐ¾ Ð¼Ð¾Ð»ÐµÐºÑÐ»Ñ Ð´Ð¾ÐºÑÐ¾ÑÑÐ±Ð¸ÑÐ¸Ð½Ð° Ð¿ÑÐµÐ¶Ð´Ðµ Ð²ÑÐµÐ³Ð¾ Ð¾Ð±ÑÐ°Ð·ÑÑÑ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÑ Ñ Ð¿Ð¾Ð²ÐµÑÑÐ½Ð¾ÑÑÐ½ÑÐ¼Ð¸/Ð²Ð½ÐµÑÐ½Ð¸Ð¼Ð¸ Ð¼Ð¾Ð»ÐµÐºÑÐ»Ð°Ð¼Ð¸ Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ° Ð² ÑÑÐ¾Ð¹Ð½Ð¾Ð¼ Ð½Ð°Ð½Ð¾ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐµ. ÐÑÐ¸ ÑÑÐ¾Ð¼ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸Ñ ÑÐµÐ»ÐµÐ½Ð° Ñ Ð¿Ð¾Ð»Ð¸Ð²Ð¸Ð½Ð¸Ð»Ð¿Ð¸ÑÑÐ¾Ð»Ð¸Ð´Ð¾Ð½Ð¾Ð¼ Ð¿ÑÐ¾Ð¸ÑÑÐ¾Ð´Ð¸Ñ Ð·Ð° ÑÑÐµÑ Ð³Ð¸Ð´ÑÐ¾ÑÐ¾Ð±Ð½ÑÑ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ð¹, Ð° Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ Ð¼ÐµÐ¶Ð´Ñ Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ¾Ð¼ Ð¸ Ð´Ð¾ÐºÑÐ¾ÑÑÐ±Ð¸ÑÐ¸Ð½Ð¾Ð¼ Ð·Ð° ÑÑÐµÑ Ð³Ð¸Ð´ÑÐ¾ÑÐ¾Ð±Ð½ÑÑ Ð¸ Ð²Ð¾Ð´Ð¾ÑÐ¾Ð´Ð½ÑÑ ÑÐ²ÑÐ·ÐµÐ¹. Ð¡ÑÐ°Ð²Ð½ÐµÐ½Ð¸Ðµ ÑÐ¿ÐµÐºÑÑÐ°Ð»ÑÐ½ÑÑ Ð¸ ÑÐ°Ð·Ð¼ÐµÑÐ½ÑÑ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸Ðº ÑÑÐ¾Ð¹Ð½ÑÑ Ð½Ð°Ð½Ð¾ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ¾Ð² Ð´Ð°ÑÐ½Ð¾Ð¼Ð¸ÑÐ¸Ð½Ð° Ð¸ Ð´Ð¾ÐºÑÐ¾ÑÑÐ±Ð¸ÑÐ¸Ð½Ð° Ð¿Ð¾ÐºÐ°Ð·Ð°Ð»Ð¾, ÑÑÐ¾ Ð´Ð°ÑÐ½Ð¾Ð¼Ð¸ÑÐ¸Ð½ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²ÑÐµÑ Ñ ÐºÐ¾Ð¼Ð¿Ð¾Ð½ÐµÐ½ÑÐ°Ð¼Ð¸ Ð½Ð°Ð½Ð¾ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ° ÑÐ¾Ð»ÑÐºÐ¾ Ð·Ð° ÑÑÐµÑ Ð³Ð¸Ð´ÑÐ¾ÑÐ¾Ð±Ð½ÑÑ ÑÐ²ÑÐ·ÐµÐ¹, Ð° Ð´Ð¾ÐºÑÐ¾ÑÑÐ±Ð¸ÑÐ¸Ð½ Ð¾Ð±ÑÐ°Ð·ÑÐµÑ Ð³Ð¸Ð´ÑÐ¾ÑÐ¾Ð±Ð½ÑÐµ Ð¸ Ð²Ð¾Ð´Ð¾ÑÐ¾Ð´Ð½ÑÐµ ÑÐ²ÑÐ·Ð¸. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ ÑÐ²ÐµÐ´ÐµÐ½Ð¸Ñ Ð¼Ð¾Ð³ÑÑ Ð±ÑÑÑ Ð²Ð¾ÑÑÑÐµÐ±Ð¾Ð²Ð°Ð½Ñ Ð¿ÑÐ¸ ÑÑÐ°Ð²Ð½Ð¸ÑÐµÐ»ÑÐ½Ð¾Ð¹ Ð¾ÑÐµÐ½ÐºÐµ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ¾Ð² Ñ Ð¾Ð¿ÑÑÐ¾Ð»ÐµÐ²ÑÐ¼Ð¸ ÐºÐ»ÐµÑÐºÐ°Ð¼Ð¸ Ð² ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ð¸ Ñ Ð¾Ð´Ð¸Ð½Ð¾ÑÐ½ÑÐ¼ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸ÐµÐ¼ Ð°Ð½ÑÑÐ°ÑÐ¸ÐºÐ»Ð¸Ð½Ð¾Ð²ÑÑ Ð°Ð½ÑÐ¸Ð±Ð¸Ð¾ÑÐ¸ÐºÐ¾Ð².
description: In this work, the processes of formation and stabilization of selenium nanoparticles in the presence of the antitumor antibiotic doxorubicin and polyvinylpyrrolidone are studied. It is found that doxorubicin does not stabilize selenium nanoparticles. The study of the complex of doxorubicin with polyvinylpyrrolidone by methods of spectrophotometric titration and modified isomolar series showed that the âStrongest" intermolecular interactions are carried out on the hydrophobic fragment of doxorubicin. The two developed methods synthesized ternary nanocomplexes âselenium nanoparticles - polyvinylpyrrolidone - doxorubicinâ. The effects of the synthesis method on the spectral and dimensional characteristics of triple nanocomplexes are investigated. It is shown that the synthesis methods used in the work made it possible to obtain stable complexes characterized by a unimodal size distribution. It has been established that doxorubicin molecules primarily form complexes with surface / external polymer molecules in a ternary nanocomplex. In this case, the interaction of selenium nanoparticles with polyvinylpyrrolidone occurs due to hydrophobic interactions, and the interaction between the polymer and doxorubicin due to hydrophobic and hydrogen bonds. A comparison of the spectral and dimensional characteristics of ternary nanocomplexes of daunomycin and doxorubicin showed that daunomycin interacts with the components of the nanocomplex only due to hydrophobic bonds, and doxorubicin forms hydrophobic and hydrogen bonds. The information obtained can be used in a comparative assessment of the effectiveness of the interaction of complexes with tumor cells in comparison with the single use of anthracycline antibiotics.