cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of Integrating cfDNA liquid biopsy and organoid-based drug screening reveals PI3K signaling as a promising therapeutic target in colorectal cancer
Creators: name: Yang, Huan
name: Xiao, Xing
name: Zeng, Leli
name: Zeng, Haiteng
name: Zheng, Yueyuan
name: Wang, Jingshu
name: Li, Guanghua
name: Dai, Weigang
name: He, Yulong
name: Wang, Suihai
name: Peng, Jianjun
name: Chen, Wei
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Virology

description: Additional file 1. Figure S1. eEarly-stage tumors identified in a patient with P-J syndrome.. Colonoscopy diagnosis and HE staining of the tumors from a PJS patient. A and B, colonoscopy images showing the polyps (A) and the bulk tumor (B) detected in the ascending colon and sigmoid colon, respectively. C and D, HE staining of the biopsies from A and B at 40x magnification, respectively. E and F, HE staining of the biopsies from A and B at 100x magnification, respectively. The white circles in the plots indicate polys or tumors found under colonoscopy. The scale bars in the plots stand for 625 μm (C and D) or 200 μm (E and F). Figure S2. RNA sequencing analysis of organoid treated with Alpelisib. A, Volcano plot showing the differentially expressed genes comparing Alpelisib treated and control CRC-1 organoid. Genes upregulated in the treated group are depicted in orange, while those downregulated are shown in blue. B, Heatmap of top differentially expressed genes comparing Alpelisib treated and control CRC-1 organoid. C and D, GO analysis of up-regulated genes and down-regulated genes. E, F and G, Gene enrichment plots showing the PI3K_AKT_MTOR, APOPTOSIS, E2F_TARGETS pathways. Table S1. All mutations detected in the liquid biopsy of patients.
THE BRAZILIAN PARTY POLITICAL CRISIS: THE END OF THE COLLABORATIONS FOR PROPORTIONAL ELECTIONS, ADOPTION OF THE BARRIER CLAUSE AND THE ELIMINATION OF PROVISIONAL COMMITTEES, SUGGESTIONS FOR TRUE POLITICAL REFORM IN BRAZIL
Creators: name: HORÁCIO MONTESCHIO
name: FRANCISCO PEDRO JUCÁ
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: The Brazilian political framework needs urgent changes. The possibility of granting public "sponsorship" made by the party fund, without any specific rule of destination of these public resources, is open to question. In the same scenario the "electoral coalitions" end up creating an esdrúxula situation in the elect. The multiparty system was totally distorted by the indiscriminate creation of political parties. The parties began to constitute a patrimony of a certain politician. This seizure is possible only in view of the presence in the electoral system of "provisional commissions" that represent the most backward in the Brazilian political system.
Malfilanol C, a new sesquiterpenoid isolated from the deep-sea-derived Aspergillus puniceus A2 fungus
Creators: name: Niu, Siwen
name: Huang, Shuhuan
name: Wang, Juan
name: He, Jianlin
name: Chen, Meixiang
name: Zhang, Gaiyun
name: Hong, Bihong
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: The chemical examination of the rice solid fermentation products of the deep-sea-derived fungus Aspergillus puniceus A2 resulted in the isolation of one new sesquiterpenoid malfilanol C (1), together with a rare analogue malfilanol B (2). The planar structure of 1 was resolved on the basis of the extensive analyses of the spectroscopic data (HRESIMS and NMR spectra), and its absolute configuration was assigned by quantum chemical calculation of the ECD data. Compound 1, featuring a bicyclo[5.4.0]-undecane nucleus skeleton, was the third example of this subclass sesquiterpenoids found from nature. Additionally, the subclass sesquiterpenoids 1 and 2 were discovered from marine-derived-fungi for the first time. All the isolated metabolites were evaluated the antibacterial activities against Staphylococcus aureus ATCC 29213 and Escherichia coli ATCC 25922. Compound 1 exhibited weak antibacterial activity against S. aureus ATCC 29213.
New bisbenzylisoquinoline alkaloid, isolation and structure elucidation from Cocculus pendulus
Creators: name: Sultani, Shaikh Ziauddin
name: Anwar, Muhammad Aijaz
name: Alam, Muhammad Shahab
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biophysics
Biochemistry
Pharmacology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified

description: This paper describes phytochemical studies on aerial part of the Cocculus pendulus, which led to the identification of a new ingredient namely, 2 N-methylkohatine (1) along with four reported compounds Kohatine (2), 1,2-Dehydrokohatine (3) and 5′Hhydroxyapateline (4). Structures of the all Compounds were elucidated by using 1 D and 2 D NMR and mass spectroscopy furthermore the structure of new Compound 1 was also proved by synthesize from compound 2 (Kohatine).
Privacy in Open Search: A Review of Challenges and Solutions
Creators: name: Sousa, Samuel
name: Guetl, Christian
name: Kern, Roman
Publisher: name: arXiv
Year: 2021
Subjects: subject: Cryptography and Security (cs.CR)
subject: Artificial Intelligence (cs.AI)
subject: Information Retrieval (cs.IR)
subject: FOS: Computer and information sciences

description: Privacy is of worldwide concern regarding activities and processes that include sensitive data. For this reason, many countries and territories have been recently approving regulations controlling the extent to which organizations may exploit data provided by people. Artificial intelligence areas, such as machine learning and natural language processing, have already successfully employed privacy-preserving mechanisms in order to safeguard data privacy in a vast number of applications. Information retrieval (IR) is likewise prone to privacy threats, such as attacks and unintended disclosures of documents and search history, which may cripple the security of users and be penalized by data protection laws. This work aims at highlighting and discussing open challenges for privacy in the recent literature of IR, focusing on tasks featuring user-generated text data. Our contribution is threefold: firstly, we present an overview of privacy threats to IR tasks; secondly, we discuss applicable privacy-preserving mechanisms which may be employed in solutions to restrain privacy hazards; finally, we bring insights on the tradeoffs between privacy preservation and utility performance for IR tasks.
description: Paper accepted at OSSYM 2021 - Third International Open Search Symposium
Generații. Politici generaționale și relații intergeneraționale. Un compendiu multilingvistic
Creators: name: Klimczuk, Andrzej
name: Lüscher, Kurt
name: Hoff, Andreas
name: Lamura, Giovanni
name: Renzi, Marta
name: Oliveira, Paulo De Salles
name: Sánchez, Mariano
name: Viry, Gil
name: Widmer, Eric
name: Neményi, Ágnes
name: Enikő Veress
name: Bjursell, Cecilia
name: Ann-Kristin Boström
name: Gražina Rapolienė
name: Sarmitė Mikulionienė
name: Oğlak, Sema
name: Ayşe Canatan
Publisher: name: figshare
Year: 2017
Subjects: subject: Sociology
subject: FOS: Sociology

description: The members of the International Network for the Analysis of Intergenerational Relations (Generationes) proudly present the most recent issue of the jointly produced compendium "Generations, Intergenerational Relations and Generational Policy". This new version includes 12 languages: English, French, German, Italian, Spanish, Polish, Portuguese, Swedish (new), Hungarian (new), Turkish (new), Romanian (new), and Lithuanian (new). The layout of the compendium is designed for using it to translate the specific concepts and terminology of research into generations and intergenerational relations from one language into another.
Additional file 1 of The impact of COVID-19 on the number of active small primary care businesses by severity of the pandemic: evidence from South Korea
Creators: name: Son, Kyung-Bok
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology
subject: FOS: Biological sciences
subject: Computational Biology

description: Additional file 1: Supplement 1. Basic characteristics of three areas, including metropolitan, the most affected, and the remaining area.
Isocratic elution based analytical method for quantification of phytoconstituents in Hedychium spicatum and evaluation of their α-glucosidase inhibitory activity
Creators: name: Maurya, Antim K.
name: Kumar, Pawan
name: Agnihotri, Vijai K.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Plant Biology
subject: FOS: Biological sciences

description: An efficient, fast, selective and simple isocratic elution method has been established using ultra performance liquid chromatography coupled to photodiode array detection and electrospray ionisation mass spectrometry (UPLC-PDA-ESI-MS) techniques for the quantification of isolated molecules from Hedychium spicatum rhizomes and assess their α-glucosidase inhibitory activity. Developed analytical method was validated as per the regulatory guidelines such as linearity, selectivity, the limits of detection (LOD) and quantification (LOQ), repeatability and accuracy. Highest concentration of 7-hydroxy hedychenone (4) (76.7 mg/g of dried plant material) was detected in rhizomes. Present results demonstrated parent extract (ethanolic) had the greatest inhibitory effect on α-glucosidase with IC50 values of 4.0 µg/mL. Developed method can be used as a new analytical approach for quality assessment of H. spicatum based herbal formulations and other products. Furthermore, current findings showed that the extract, fraction and isolated metabolites may be a good natural antidiabetic.
Nemzedékek, nemzedékek közötti kapcsolatok, nemzedéki politika. Többnyelvű kompendium
Creators: name: Klimczuk, Andrzej
name: Lüscher, Kurt
name: Hoff, Andreas
name: Lamura, Giovanni
name: Renzi, Marta
name: Oliveira, Paulo De Salles
name: Sánchez, Mariano
name: Viry, Gil
name: Widmer, Eric
name: Neményi, Ágnes
name: Enikő Veress
name: Bjursell, Cecilia
name: Ann-Kristin Boström
name: Gražina Rapolienė
name: Sarmitė Mikulionienė
name: Oğlak, Sema
name: Ayşe Canatan
Publisher: name: figshare
Year: 2017
Subjects: subject: Sociology
subject: FOS: Sociology

description: The members of the International Network for the Analysis of Intergenerational Relations (Generationes) proudly present the most recent issue of the jointly produced compendium "Generations, Intergenerational Relations and Generational Policy". This new version includes 12 languages: English, French, German, Italian, Spanish, Polish, Portuguese, Swedish (new), Hungarian (new), Turkish (new), Romanian (new), and Lithuanian (new). The layout of the compendium is designed for using it to translate the specific concepts and terminology of research into generations and intergenerational relations from one language into another.
Additional file 1 of Bidirectional two-sample Mendelian randomization analysis identifies causal associations between cardiovascular diseases and frozen shoulder
Creators: name: Lu, WeiSong
name: Pu, Bin
name: Wang, Sen
name: Li, MengZe
name: An, Yue
name: Lian, Jie
name: Wang, YongQuan
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Additional file 1. Table S1. Characteristics of SNPs associated with cardiovascular disease. Table S2. Characteristics of SNPs associated with frozen shoulder. Table S3. Heterogeneity and pleiotropy analysis in reverse MR analysis. Fig S1. The forest plots for causal effect of cardiovascular disease on frozen shoulder. Fig S2. Leave-one-out sensitivity analysis for causal effect of cardiovascular disease on frozen shoulder. Fig S3. The funnel chart for causal effect of cardiovascular disease on frozen shoulder. Fig. S4. The scatter plots for causal effect of frozen shoulder on cardiovascular disease. Fig. S5. The forest plots for causal effect of frozen shoulder on cardiovascular disease. Fig. S6. Leave-one-out sensitivity analysis for causal effect of frozen shoulder on cardiovascular disease. Fig. S7. The funnel chart for causal effect of frozen shoulder on cardiovascular disease.
INFORMATION EXCHANGE AGAINST FISCAL FRAUD AND EVASION
Creators: name: LUCIANA GRASSANO MELO
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: The exchange of information is part of the more general theme of international tax cooperation. It is a very current issue both in the European Union and among OECD member countries, since obtaining information in the face of a globalized economy scenario through international cooperation is the only means of achieving the goal of combating financial erosion Budgets and fiscal systems of the most diverse sovereign States, and is an important tool to combat drug trafficking, weapons, terrorism, corruption, among others.
title: Lettre de Jacques Leibowitch au Docteur Paul Kelly (Hôpital Necker)
Creators: name: Leibowitch, Jacques
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Source: http://www.calames.abes.fr/pub/ms/Calames-20193111134190923
Synthesis, X-ray structure and anticancer activity evaluation of a binuclear La(III) complex with anthranilic acid
Creators: name: Zidan, Amna S. A.
name: Mosbah, Hanan K.
name: Aly, Aref A. M.
name: Ibrahim, Ahmed B. M.
name: Mayer, Peter
name: Saber, Saber H.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: A binuclear La(III) complex {[La2(HA)4(H2O)4(C2H5OH)2Cl2]Cl4 (C1)} with 2-aminobenzoic acid (HA) was prepared from the ligand and heptahydrated lanthanum chloride. The complex was characterised by X-ray crystallography that revealed anti-prismatic geometry around both of the lanthanum. In the complex, the four 2-aminobenzoic acid ligands are zwitter ionic and the two lanthanum(III) ions net charge is only counterbalanced by chloride ions. The complex cytotoxicity was determined against human breast (MDA-MB-231), prostate (PC-3) and bladder (T-24) cancer cells. This complex afforded cytotoxicity towards the T-24 bladder cancer cells with an IC50 value of 383.5 µg/mL (319 µM). In contrary, activities by the lanthanum complex with IC50 values of 1124 µg/mL (934 µM) and 739 µg/mL (614 µM) were, respectively, shown against the MDA-MB-231 and PC-3 cancer cells. This means the complex is more cytotoxic against the T-24 cells, despite that its activity is less compared with activities shown by classical drugs.
Two new rakicidin derivatives from marine Micromonospora chalcea FIM-R160609
Creators: name: Chen, Li
name: Xie, Lijun
name: Zhao, Wei
name: Zhou, Jian
name: Jiang, Honglei
name: Liu, Wei
name: Jiang, Hong
name: Lin, Feng
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: The establishment of structure activity relationship (SAR) for rakicidin derivatives is pretty vital to develop rakicidins as a new type of anti-cancer agents. Herein, two novel rakicidin derivatives, compounds B1-1 (1) and B1-2 (2), a cyclic depsipeptide and a chain lipopeptide, respectively, were isolated from culture broth of Micromonospora chalcea FIM-R160609, and their structures were elucidated clearly by extensive NMR and HR-ESI-MS analyses. Following, their cytotoxic activities were evaluated against HCT-8 and PANC-1 human cancer cell lines under hypoxic and normoxic conditions. Their activities were significantly decreased when compared with that of rakicidin B1. These results demonstrated that the double bond located on the position 9 and 10 of conjugated diene unit and cycle-type structure plays an important role in keeping the biological activity of rakicidins. Furthermore, the positive effect of double bond and cycle form on the anti-bacterial activities were also confirmed by testing their inhibitory activities against gram positive bacteria. This work will definitely diversify the SAR of rakicidins and provide the guidance for the design of new potent rakicidin analogues.
Additional file 1 of Routes of transmission of VIM-positive Pseudomonas aeruginosa in the adult intensive care unit-analysis of 9 years of surveillance at a university hospital using a mathematical model
Creators: name: Pham, Thi Mui
name: Büchler, Andrea C.
name: Voor in ‘t holt, Anne F.
name: Severin, Juliëtte A.
name: Bootsma, Martin C. J.
name: Gommers, Diederik
name: Kretzschmar, Mirjam E.
name: Vos, Margreet C.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Additional file 1. Supplement 1. Overview of infection prevention and control measures. Supplement 2. Genotyping results of patients. Supplement 3. overview of environmental screenings.
Malfilanol C, a new sesquiterpenoid isolated from the deep-sea-derived Aspergillus puniceus A2 fungus
Creators: name: Niu, Siwen
name: Huang, Shuhuan
name: Wang, Juan
name: He, Jianlin
name: Chen, Meixiang
name: Zhang, Gaiyun
name: Hong, Bihong
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: The chemical examination of the rice solid fermentation products of the deep-sea-derived fungus Aspergillus puniceus A2 resulted in the isolation of one new sesquiterpenoid malfilanol C (1), together with a rare analogue malfilanol B (2). The planar structure of 1 was resolved on the basis of the extensive analyses of the spectroscopic data (HRESIMS and NMR spectra), and its absolute configuration was assigned by quantum chemical calculation of the ECD data. Compound 1, featuring a bicyclo[5.4.0]-undecane nucleus skeleton, was the third example of this subclass sesquiterpenoids found from nature. Additionally, the subclass sesquiterpenoids 1 and 2 were discovered from marine-derived-fungi for the first time. All the isolated metabolites were evaluated the antibacterial activities against Staphylococcus aureus ATCC 29213 and Escherichia coli ATCC 25922. Compound 1 exhibited weak antibacterial activity against S. aureus ATCC 29213.
A simple synthesis of α-Costic acid analogue with antibacterial potential, DFT and molecular docking
Creators: name: Maaghloud, F. E.
name: Moukhfi, F.
name: Abdou, A.
name: Chadli, N.
name: Aboulmouhajir, A.
name: Elmakssoudi, H.
name: Hakmaoui, A. El
name: Eddine, J. Jamal
name: Akssira, M.
name: Dakir, M.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Natural products extracted from plants has been recognized as the most efficient starting materials to synthesize new derivatives of medicinal interest. Our research focuses on the isolation and characterization of sesquiterpene derivatives from Dittrichia Viscosa (L), as well as their hemisynthesis. To that end, a phytochemical study of Dittrichia viscosa leaves was conducted in order to obtain a sesquiterpenoid, α -Costic acid, which will be further transformed to γ -Costic acid with high yield using simple processes. Optimized molecular geometry and vibrational frequencies of both products were computed using the density functional theory. In addition, the antibacterial activity of isolated and hemisynthesized products were analyzed in vitro against Escherichia coli resistant to β-lactamase 616, Pseudomonas aeruginosa, and Staphylococcus aureus. The obtained compounds were investigated by in silico biological method to evaluate their potential inhibitory activity against same strains using FtsA, LasR proteins and DNA polymerase III enzyme.
title: 02_1219
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Additional file 1 of Lifetime impact of being underweight or overweight/obese during childhood in Vietnam
Creators: name: Baek, Yeji
name: Owen, Alice J.
name: Fisher, Jane
name: Tran, Thach
name: Ademi, Zanfina
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: Additional file 1: Table 1. Model inputs.
Additional file 2 of Lifetime impact of being underweight or overweight/obese during childhood in Vietnam
Creators: name: Baek, Yeji
name: Owen, Alice J.
name: Fisher, Jane
name: Tran, Thach
name: Ademi, Zanfina
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: Additional file 2:Supplementary Figure 1. Differences in study outcomes ((A) deaths, (B) years of life lived, (C) QALYs) between various scenarios and base-case results.
Catechins and other phenolic compounds in herb of eight Ephedra species in comparison to Camellia sinensis
Creators: name: Osmic, Nudjejma
name: Culum, Dusan
name: Ibragic, Saida
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: Using HPLC-DAD the presence of catechin, epicatechin, quercetin, kaempferol and protocatehuic acid was analysed in herb extracts of eight Ephedra species (Ephedra sinica, Ephedra major, Ephedra chilensis, Ephedra ciliata, Ephedra foeminea, Ephedra equisetina, Ephedra gerardiana and Ephedra distachya). For comparison purposes, the same phenolics were determined in Camellia sinensis herb, which is a common source of catechins and a medicinal plant with valuable antioxidant properties. The catechin content in Ephedra spp. ranged between 0.83 mg/g d.w.– 8.77 mg/g d.w., while the epicatechin content was between 0.11 mg/g d.w.– 3.38 mg/g d.w. In comparison to black tea, Ephedra major, Ephedra distachya and Ephedra equisetina had a higher catechin content. The selected Ephedra spp. are rich in catechins and the obtained results serve as the chemical rationale for the anti-inflammatory, antioxidant and anti-proliferative activities of Ephedra that are currently being investigated.
Additional file 1 of Effectiveness of CT radiomic features combined with clinical factors in predicting prognosis in patients with limited-stage small cell lung cancer
Creators: name: Wu, Jiehan
name: Zhou, Yuntao
name: Xu, Chang
name: Yang, Chengwen
name: Liu, Bingxin
name: Zhao, Lujun
name: Song, Jiawei
name: Wang, Wei
name: Yang, Yining
name: Liu, Ningbo
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Mathematical Sciences not elsewhere classified
Cancer
Hematology

description: Additional file 1: The formula for RadScore_OS and RadScore_PFS. Supplemental Figure 1. Heatmap of all features. Supplemental Figure 2. Comparison of cases with good and poor prediction results.
DFG Research Unit Magnetosphere, Ionosphere, Plasmasphere and Thermosphere, as a coupled system (MIPT)
Creators: name: Yuri Shprits
Publisher: name: Zenodo
Year: 2024

description: The overarching science objective of the research unit will be to better understand how the magnetosphere, ionosphere, plasmasphere, and thermosphere are coupled to each other. The complexity of this system which covers altitudes from tens to tens of thousands of km and over time scales from minutes to decades, requires an interdisciplinary team with experts in different domains, expertise in modeling and observations, as well as established collaborative ties to the international community. The work outlined in this proposal will advance our understanding of the coupled systems. The main overarching question is: how do the disturbances in the solar wind drive the coupled MIPT system and how do subsystems of MIPT influence each other on different time and spatial scales? The RU will consist of the following institutions:  The Deutsches Geodätisches Forschungsinstitut der Technischen Universität München (DGFI-TUM), Institute of Geodesy and Geoinformation (IGG) of the University of Bonn, Geophysics section at Ludwig Maximilian University (LMU), Munich, German Research Centre for Geosciences (GFZ), Potsdam,  DLR Institute for Solar-Terrestrial Physics, Institute for  Physics and Astronomy, University of Potsdam (UP), the Institute for Geosciences, and interdisciplinary collaborative research centers (SFB). Data assimilation will play a crucial part for this project. UP will consult and meet with astrophysicists, geoscientists, mathematicians, and computer scientists.The project consists of the following projects: Project code    Project title    Researchers    Research areas1    Observed change in the thermosphere and TI-coupling    J. Kusche    TI (PI)2    Modeling and forecasting of the Electron Density distribution within the IonoSphere     M. Schmidt, C. Borries, T. Gerzen    IP (MT)3    Coupled plasmasphere-ionosphere dynamics    Y. Shprits    PI (MT)4    Understanding the acceleration of the radiation belt electrons to ultra-relativistic energies and its dependence on the plasma density    Y. Shprits    MP (TI)5    Energy deposition from the magnetotail into the ionosphere/thermosphere    E. Kronberg    MIT (P)6    Electron Seed Population and its impact on Ring current, Ionosphere/Thermosphere dynamics    E. Kronberg , Y. Shprits    MIT (P)
New butanolide derivatives from the marine derived fungus Aspergillus terreus GZU-31-1 by chemical epigenetic manipulation
Creators: name: Zhou, Yuwei
name: Chen, Xiaocong
name: Tang, Yuqian
name: Liu, Yena
name: Zhao, Zhongxiang
name: Cui, Hui
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Neuroscience
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine

description: Chemical epigenetic manipulation of Aspergillus terreus GZU-31-1 led to the discovery of five butanolide derivatives (1–5), including two new ones (1 and 2), and four known diphenyl ether derivatives (6−9). Compound 1 featured a Z-configuration double bond in the isoprenyl group was a potential anti-inflammatory bioactive group. Compound 2 was a new natural product. Moreover, compound 3 with a deacetylated group at C-4 was rarely reported as a butanolide analogue, which was isolated from the liquid culture treated with polyketide pathway inhibitor sodium citrate dihydrate. All of the isolates (1−9) were tested for their anti-inflammatory effects on the production of nitric oxide in lipopolysaccharide-induced microglial cells (RAW 264.7 cells). Compounds 1, 7, 8 and 9 exhibited more potent anti-inflammatory activity with IC50 values of 16.31, 20.16, 9.53 and 21.64 μM than the positive control (indomethacin, IC50, 24.0 μM).
THE REFLECTIONS OF THE INSTITUTIONAL ENVIRONMENT IN ENTREPRENEURSHIP
Creators: name: RENATA ALBUQUERQUE LIMA
name: ALEXANDER PERAZO NUNES DE CARVALHO
name: ÁTILA DE ALENCAR ARARIPE MAGALHÃES
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: This article analyzes the influence of the institutional environment of entrepreneurship. Factors such as religion, form of colonization, rules and regulations, public policy, education, environmental culture, restrictions on behavior imposed by the rules of the state or society that shape economic interactions, and to the internationalization of the economy are studied in order to check if they somehow impact entrepreneurship. From another perspective, the institutions also influence the economy, specifically with their transaction costs and processing, which reverberate in the economic activity of a given environment. In this sense, the economic analysis of law provides tools to understand how entrepreneurship can be influenced by the economy. The research presents a qualitative approach to these influences on entrepreneurship and was carried out through literature based on books, national and international journals and magazines. The study noted the importance of entrepreneurship in the social and economic development of a nation
Secondary metabolites isolated from Penicillium christenseniae SD.84 and their antimicrobial resistance effects
Creators: name: Wang, Xinzhu
name: Meng, Qingzhou
name: Chen, Haiyan
name: Yin, Xin
name: Dai, Huanqin
name: Zhao, Peipei
name: Pan, Yang
name: Xia, Xuekui
name: Zhang, Lixin
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: A pair of new quinolone alkaloid enantiomers, (Ra)-(-)-viridicatol (1) and (Sa)-(+)-viridicatol (4), and seven known compounds, namely, 2, 3 and 5–9, were isolated from Penicillium christenseniae SD.84. The structures of 1 and 4 were determined using NMR and HRESIMS data. Theoretical calculations through CD and ECD confirmed 1 and 4 as a pair of enantiomers. The MIC values of 4 against Staphylococcus aureus and methicillin-resistant S. aureus were 12.4 and 24.7 μM, respectively, compound 1 had no inhibitory activity. Antimicrobial assays of 2, 3, and 5–7 showed a moderate activity against S. aureus and methicillin-resistant S. aureus. This study demonstrated the remarkable potential of Penicillium sp. to produce new drug-resistant leading compounds, thereby advancing the mining for new sources of antimicrobial agents.
Generation, relationer mellan generationer, generationspolicy. Ett mångspråkigt kompendium
Creators: name: Klimczuk, Andrzej
name: Lüscher, Kurt
name: Hoff, Andreas
name: Lamura, Giovanni
name: Renzi, Marta
name: Oliveira, Paulo De Salles
name: Sánchez, Mariano
name: Viry, Gil
name: Widmer, Eric
name: Neményi, Ágnes
name: Enikő Veress
name: Bjursell, Cecilia
name: Ann-Kristin Boström
name: Gražina Rapolienė
name: Sarmitė Mikulionienė
name: Oğlak, Sema
name: Ayşe Canatan
Publisher: name: figshare
Year: 2017
Subjects: subject: Sociology
subject: FOS: Sociology

description: The members of the International Network for the Analysis of Intergenerational Relations (Generationes) proudly present the most recent issue of the jointly produced compendium "Generations, Intergenerational Relations and Generational Policy". This new version includes 12 languages: English, French, German, Italian, Spanish, Polish, Portuguese, Swedish (new), Hungarian (new), Turkish (new), Romanian (new), and Lithuanian (new). The layout of the compendium is designed for using it to translate the specific concepts and terminology of research into generations and intergenerational relations from one language into another.
The Impact of the Coronavirus Pandemic on New York City Real Estate: First Evidence
Creators: name: Cohen, Jeffrey P.
name: Friedt, Felix L.
name: Lautier, Jackson P.
Publisher: name: arXiv
Year: 2021
Subjects: subject: General Economics (econ.GN)
subject: FOS: Economics and business

description: We investigate whether pandemic-induced contagion disamenities and income effects arising due to COVID-related unemployment adversely affected real estate prices of one- or two-family owner-occupied properties across New York City (NYC). First, OLS hedonic results indicate that greater COVID case numbers are concentrated in neighborhoods with lower-valued properties. Second, we use a repeat-sales approach for the period 2003 to 2020, and we find that both the possibility of contagion and pandemic-induced income effects adversely impacted home sale prices. Estimates suggest sale prices fell by roughly $60,000 or around 8% in response to both of the following: 1,000 additional infections per 100,000 residents; and a 10-percentage point increase in unemployment in a given Modified Zip Code Tabulation Area (MODZCTA). These price effects were more pronounced during the second wave of infections. Based on cumulative MODZCTA infection rates through 2020, the estimated COVID-19 price discount ranged from approximately 1% to 50% in the most affected neighborhoods, and averaged 14%. The contagion effect intensified in the more affluent, but less densely populated NYC neighborhoods, while the income effect was more pronounced in the most densely populated neighborhoods with more rental properties and greater population shares of foreign-born residents. This disparity implies the pandemic may have been correlated with a wider gap in housing wealth in NYC between homeowners in lower-priced and higher-priced neighborhoods.
description: 38 pages, 5 tables, 3 figures, Revised 1/27/2022
Pokolenia, relacje międzypokoleniowe, polityka relacji międzypokoleniowych. Wielojęzyczne kompendium
Creators: name: Klimczuk, Andrzej
name: Lüscher, Kurt
name: Hoff, Andreas
name: Lamura, Giovanni
name: Renzi, Marta
name: Oliveira, Paulo De Salles
name: Sánchez, Mariano
name: Viry, Gil
name: Widmer, Eric
name: Neményi, Ágnes
name: Enikő Veress
name: Bjursell, Cecilia
name: Ann-Kristin Boström
name: Gražina Rapolienė
name: Sarmitė Mikulionienė
name: Oğlak, Sema
name: Ayşe Canatan
Publisher: name: figshare
Year: 2017
Subjects: subject: Sociology
subject: FOS: Sociology

description: Członkowie Międzynarodowej Sieci Relacji Międzypokoleniowych (Generationes) z dumą prezentują najnowsze wydanie wspólnie opracowanego kompendium "Pokolenia, relacje międzypokoleniowe, polityka relacji międzypokoleniowych". Nowa wersja zawiera 12 języków: angielski, francuski, niemiecki, włoski, hiszpański, polski, portugalski, szwedzki (nowy), węgierski (nowy), turecki (nowy), rumuński (nowy) oraz litewski (nowy). Układ kompendium został zaprojektowany tak, aby możliwe było stosowanie go do tłumaczenia konkretnych pojęć i terminologii z zakresu badań nad pokoleniami i relacjami międzypokoleniowymi z jednego języka na inny.
Köthe's Problem, Kurosch-Levitzki Problem and Graded Rings
Creators: name: de França, Antonio
name: Sviridova, Irina
Publisher: name: arXiv
Year: 2021
Subjects: subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics
subject: 16W50 (Primary), 13A02, 16R10, 16W22 (Secondary)

description: Let $\mathfrak{R}$ be an associative ring graded by left cancellative monoid $\mathsf{S}$, and $e$ the neutral element of $\mathsf{S}$. We study the following problem: if $\mathfrak{R}_e$ is nil, then is $\mathfrak{R}$ nil/nilpotent? We have proved that if $\mathfrak{R}_e$ is nil (of bounded index) and $\mathsf{f}$- commutative, then $\mathfrak{R}$ is nil (of bounded index). Later, we have shown that $\mathfrak{R}_e$ being nilpotent implies $\mathfrak{R}$ is nilpotent. Consequently, we have exhibited a generalization of Dubnov-Ivanov-Nagata-Higman Theorem for the graded algebras case. Furthermore, we have exhibited relations between graded rings and the problems of Köthe and Kurosh-Levitzki. We have proved that graded rings and $\mathsf{f}$-commutative rings provide positive solutions to these problems.
Software
Creators: name: Searston, Rachel A.
name: Sullivan, Carly
Publisher: name: OSF Registries
Year: 2019

description: This component contains the full set of 24 pre-generated unique participant sequences (.txt) that are read into the open source experiment presentation software we developed for this project. The LiveCode source file (version 9.0.4) for presenting the sequences and materials to participants and collecting their responses is also included in the .zip files for each experiment, along with the instructional video participants view before completing each task. LiveCode’s Community Edition, is a free open source object-oriented, cross-platform, natural language rapid development environment that can be used for programming local (LiveCode) and web-based (HTML5) experiments. LiveCode is based on the Transcript programming language (a high-level xTalk scripting language like HyperCard’s HyperTalk), and is a great stepping stone to learning Javascript and Python. It is fit for developing experiments that require fine-grained control, complex sequencing, and heavy back-end processing. You can download LiveCode for PC, Linux or Mac at: https://downloads.livecode.com/livecode. You can run these experiments on your own computer (ours are running MacOS Mojave for this project) by installing the appropriate version of LiveCode Community, downloading the zip files, and loading the LC programs. The experiment folders can be stored anywhere on your machine but their file structure needs to be preserved for the experiments to run because the program is reading in the sequences, presenting the instructional videos, and showing and hiding the images on the fly.
Quantitative analysis of tiliroside and other flavonoid glycosides in Hippophae salicifolia D. Don leaves by HPLC-PDA
Creators: name: Ranjana, Soni
name: Srivastava, Amit
name: Goyal, Alok
name: Singh, Inder Pal
name: Jachak, Sanjay M.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: A new HPLC-PDA method was developed and validated for simultaneous determination of five phenolic compounds (trans-and cis- isomers of tiliroside, quercetin-3-O-β-D-glucoside, ellagic acid, kaempferol-3-O-β-D-glucoside and isorhamnetin-3-O-glucoside) in the leaves of Hippophae salicifolia D. Don. Of the five compounds, three (tiliroside, quercetin-3-O-β-D-glucoside and ellagic acid) were isolated and characterised by spectroscopy techniques. The developed HPLC method provided a selective, sensitive and rapid analysis with good linearity (r2> 0.999), accuracy and precision. Also, the leaves of H. salicifolia were extracted by three different extraction techniques viz. reflux, microwave and ultrasound. Methanolic extracts prepared by reflux method showed the highest content of all the five compounds.
Gerações, relações intergeracionais, política geracional. Um compêndio multilíngue
Creators: name: Klimczuk, Andrzej
name: Lüscher, Kurt
name: Hoff, Andreas
name: Lamura, Giovanni
name: Renzi, Marta
name: Oliveira, Paulo De Salles
name: Sánchez, Mariano
name: Viry, Gil
name: Widmer, Eric
name: Neményi, Ágnes
name: Enikő Veress
name: Bjursell, Cecilia
name: Ann-Kristin Boström
name: Gražina Rapolienė
name: Sarmitė Mikulionienė
name: Oğlak, Sema
name: Ayşe Canatan
Publisher: name: figshare
Year: 2017
Subjects: subject: Sociology
subject: FOS: Sociology

description: The members of the International Network for the Analysis of Intergenerational Relations (Generationes) proudly present the most recent issue of the jointly produced compendium "Generations, Intergenerational Relations and Generational Policy". This new version includes 12 languages: English, French, German, Italian, Spanish, Polish, Portuguese, Swedish (new), Hungarian (new), Turkish (new), Romanian (new), and Lithuanian (new). The layout of the compendium is designed for using it to translate the specific concepts and terminology of research into generations and intergenerational relations from one language into another.
Substrate rigidity-dependent positive feedback regulation between YAP and ROCK2
Creators: name: Sugimoto, Wataru
name: Itoh, Katsuhiko
name: Mitsui, Yasumasa
name: Ebata, Takahiro
name: Fujita, Hideaki
name: Hirata, Hiroaki
name: Kawauchi, Keiko
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Extracellular matrix (ECM) stiffness influences gene expression, leading to modulation of various cellular functions. While ROCK2 regulates actomyosin activity as well as cell migration and proliferation, expression of ROCK2 is increased in response to stiffening ECM. However, the mechanism underlying rigidity-dependent ROCK2 expression remains elusive. Here, we show that YAP, a mechanically regulated transcription coactivator, upregulates ROCK2 expression in an ECM rigidity-dependent manner. YAP interacted with the ROCK2 promoter region in an actomyosin activity-dependent manner. Knockdown of YAP decreased ROCK2 expression while activity of the ROCK2 promoter was upregulated by expressing constitutively active YAP. Furthermore, we found that ROCK2 expression promotes transcriptional activation by YAP. Our results reveal a novel positive feedback loop between YAP and ROCK2, which is modulated by ECM stiffness.
Linking theory and empirics: a general framework to model opinion formation processes
Creators: name: Kozitsin, Ivan V.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Social and Information Networks (cs.SI)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: We introduce a minimal opinion formation model, which is quite flexible and can reproduce a broad variety of the existing micro-influence assumptions and models. At the same time, the model can be easily calibrated on real data, upon which it imposes only a few requirements. From this perspective, our model can be considered as a bridge, connecting theoretical studies on opinion formation models and empirical research on social dynamics. We investigate the model analytically by using mean-field approximation and numerically. Our analysis is exemplified by recently reported empirical data drawn from an online social network. Employing these data for the model calibration, we demonstrate that the model may reproduce fragmented and polarizing social systems. Furthermore, we manage to generate an artificial society that features properties quantitatively and qualitatively similar to those observed empirically at the macro scale. This ability became possible after we had advanced the model with two important communication features: selectivity and personalization algorithms.
description: 59 pages, 8 figures, 6 tables
Simulations
Creators: name: Searston, Rachel A.
name: Sullivan, Carly
Publisher: name: OSF Registries
Year: 2019

description: This component contains all the raw data files (.txt) from our 24 simulated participants. These simulated participants are programmed to provide a random response on each trial in the experiment (at a random response time between 0 and 3000 milliseconds). We use the .txt files produced by these simulations to generate and test our data extraction tool, and our R Markdown analysis script for plotting and analysing the human data. These simulations also provide a handy model of chance performance, with built-in random variance rather than a constant.