cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Study on cutting performance of SiCp/Al composite using textured YG8 carbide tool
Creators: name: Wang, Xu
name: Popov, Valentin L.
name: Yu, Zhanjiang
name: Li, Yiquan
name: Xu, Jinkai
name: Yu, Huadong
Publisher: name: Technische Universität Berlin
Year: 2021
Subjects: subject: 670 Industrielle Fertigung
subject: SiCp/Al composite
subject: micro-textured tool
subject: secondary cutting

description: Precision machining of SiCp/Al composites is a challenge due to the existence of reinforcement phase in this material. This work focuses on the study of the textured tools’ cutting performance on SiCp/Al composite, as well as the comparison with non-textured tools. The results show that the micro-pit textured tool can reduce the cutting force by 5–13% and cutting length by 9–39%. Compared with non-textured tools, the cutting stability of the micro-pit textured tools is better. It is found that the surface roughness is the smallest (0.4 μm) when the texture spacing is 100 μm, and the residual stress can be minimized to around 15 MPa in the case of texture spacing 80 μm. In addition, the SiC particles with size of around 2–12 μm in the SiCp/Al composite may play a supporting role between the texture and the chips, which results in three-body friction, thereby reducing tool wear, sticking, and secondary cutting phenomenon. At the same time, some SiC particles enter into the micro-pit texture, so that the number of residual particles on the surface is reduced and the friction between the tool and the surface then decreases, which improves the surface roughness, and reduces the surface residual stress.
Complexes of DNA bases and Watson–Crick base pairs interaction with neutral silver Agn (n = 8, 10, 12) clusters: a DFT and TDDFT study
Creators: name: Srivastava, Ruby
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: We study the binding of the neutral Agn (n = 8, 10, 12) to the DNA base-adenine (A), guanine (G) and Watson–Crick –adenine-thymine, guanine-cytosine pairs. Geometries of complexes were optimized at the DFT level using the hybrid B3LYP functional. LANL2DZ effective core potential was used for silver and 6–31 + G** was used for all other atoms. NBO charges were analyzed using the Natural population analysis. The absorption properties of Agn–A,G/WC complexes were also studied using time-dependent density functional theory. The absorption spectra for these complexes show wavelength in the visible region. It was revealed that silver clusters interact more strongly with WC pairs than with isolated DNA complexes. Furthermore, it was found that the electronic charge transferred from silver to isolated DNA clusters are less than the electronic charge transferred from silver to the Agn–WC complexes. The vertical ionization potential, vertical electron affinity, hardness, and electrophilicity index of Agn–DNA/WC complexes have also been discussed.
New metabolites from the sponge-derived fungus Aspergillus sydowii J05B-7F-4
Creators: name: Liu, Sen
name: Wang, Haibo
name: Su, Mingzhi
name: Hwang, Gwi Ja
name: Hong, Jongki
name: Jung, Jee H.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Two new metabolites, diorcinolic acid (1) and β-d-glucopyranosyl aspergillusene A (8), together with six diphenylethers (2–7), a diketopiperazine (9), a chromone (10) and a xanthone (11) were isolated from the fungus Aspergillus sydowii derived from the marine sponge Stelletta sp. The planar structures and their relative configurations were elucidated by analysing 1D, 2D NMR and HRESIMS data. Compound 8 is the first glycoside of phenolic bisabolane sesquiterpenes. Compounds 1 and 8 exhibited mild cytotoxicity against KB (human nasopharyngeal carcinoma cells), HepG2 (human liver cancer cells) and HCT 116 (human colon cancer cells). All compounds were evaluated for antibacterial activity and their abilities to suppress LPS-induced nitric oxide (NO) production. Compounds 2 and 4–7 showed mild antibacterial activity against human pathogen Staphylococcus aureus and fish pathogens Streptococcus iniae and Vibrio ichthyoenteri, and compounds 4 and 7 weakly suppressed NO production.
title: 01_2861
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Regional tax evasion and audit enforcement
Creators: name: Carfora, Alfonso
name: Pansini, Rosaria Vega
name: Pisani, Stefano
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Regional tax evasion and audit enforcement. Regional Studies. Using an original panel dataset on tax gap and audits, this paper sheds light on the impact of audit and enforcement on the Italian regional tax evasion over the period 2001–11. Spatial econometric models were used to model regional tax gaps and to control for endogeneity issues and spatial patterns. Results provide evidence that greater enforcement increases tax compliance. A higher probability of targeted audits and additional schemes to increase the disclosure of declared income decrease the tax gap. The paper provides a general framework to study determinants of tax evasion at the regional level.
คุณค่าทางโภชนาการ สมบัติทางกายภาพ และการยอมรับทางประสาทสัมผัสของขนมขบเคี้ยวที่ได้รับผลจากอัตราส่วนของแป้งข้าวสินเหล็กต่อแป้งข้าวฟ่างดำที่แตกต่างกัน
Creators: name: นิภาพร กุลณา, ปาริสุทธิ์ เฉลิมชัยวัฒน์, น้องนุช ศิริวงศ์, วศะพร จันทร์พุฒ
Publisher: name: กองบริหารการวิจัย
Year: 2563
Subjects: คุณค่าทางโภชนาการ
แป้งข้าวสินเหล็ก
แป้งข้าวฟ่างดำ
ขนมขบเคี้ยว

description: วารสารวิทยาศาสตร์และเทคโนโลยี, 28, 3, 419-428
Determination of acidic herbicides in fruits and vegetables using liquid chromatography tandem mass spectrometry (LC-MS/MS)
Creators: name: Ghoniem, Islam R.
name: Attallah, Emad R.
name: Abo-Aly, Mohamed M.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: The use of quick, easy, cheap, effective, rugged and safe method followed by liquid chromatography tandem mass spectrometry (LC-MS/MS) was found to be the best combination for multiresidue determination of eight acidic herbicides in fruits and vegetables in terms of high recovery, short time of analysis, low cost and safety. Recent few articles were published for determination of different classes of acidic herbicides in single multiresidue method. In the present study, mass spectrophotometric conditions were individually optimised for eight acidic herbicides, namely 2,4-dichlorophenoxyacetic acid, bentazone, bromoxynil, fluazifop, fluroxypyr, imazethapyr, ioxynil and triclopyr to achieve maximum sensitivity and selectivity in multiple reaction monitoring (MRM) mode allowing simultaneous identification and quantification in a single run. Identity confirmation and quantitation were attained by using negative electrospray ionisation LC-MS/MS (ESI−) in MRM mode. Due to LC-MS/MS signal suppression, determination of pesticide residues was based on matrix-matched standard calculations. Most of the evaluated compounds showed a recovery ranging from 81% to 113% with relative standard deviations less than 16 % indicating acceptable precision. The precision and accuracy of the method were determined from recovery experiments on six replicates of spiked blank strawberry and green beans samples at 0.01, 0.05 and 0.1 mg/kg. The developed assay was linear over concentration range of 0.01–0.5 µg/mL, with correlation coefficient greater than 0.99 at the limit of quantitation 0.01 µg/mL. The proposed assay was successfully applied for the analysis of the studied acidic herbicides residues in two proficiency test samples. This wide scope assay protocol is applicable for monitoring acidic herbicides residues in fruits and vegetables by national regulatory authorities and accredited labs in order to help ensuring the safety of such widely used food products.
Anti-inflammatory neolignans from Epimedium pseudowushanese
Creators: name: Ti, Huihui
name: Wu, Ping
name: Xu, Liangxiong
name: Wei, Xiaoyi
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: One new 8-O-4′ neolignan has been isolated from Epimedium pseudowushanese B. L. Guo, together with nine other known neolignans. The structures of these neolignans were elucidated using spectroscopic and chemical techniques, and their anti-inflammatory activities were also evaluated. The results of these experiments revealed that compound 6 was the most potent of the 10 different compounds tested in the current study, with a maximal inhibitory ratio of 79% for its in vitro anti-inflammatory activity towards lipopolysaccharide-induced tumour necrosis factor alpha secretion in RAW264.7 cells. The other nine compounds exhibited only moderate inhibitory effects.
Food composition of the Near Eastern Fire Salamander, Salamandra infraimmaculata Martens, 1885 (Amphibia: Urodela: Salamandridae) from Eastern Anatolia
Creators: name: Çiçek, Kerim
name: Koyun, Mustafa
name: Tok, Cemal Varol
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology

description: This study presents data on the food composition of the Near Eastern Fire Salamander, Salamandra infraimmaculata, from Bingöl, eastern Turkey. A total of 139 prey items was determined in the food content of 28 individuals (14 juveniles, 7 males, and 7 females). Insecta (N%= 37.4), Gastropoda (27.3%), and Isopoda (25.9%) constitute together 91% of the food items. The most frequent prey groups in the diet are Coleoptera (F%=50.0%), Isopoda (57.1%), and Gastropoda (46.4%). Coleoptera (V%= 34.6%), Gastropoda (28.0%), and Isopoda (23.5%) had the highest prey volumes. No significant difference was found between the sexes in food composition. The species generally feeds upon poorly flying or slow-moving invertebrates, but is opportunistic in taking up more mobile prey species as well. Diptera, Odonata and Hemiptera were found in small numbers only.
IN03126 Eppāvaḷa Slab Inscription 2
Creators: name: Paranavitana, S.
Publisher: name: Zenodo
Year: 2020
Subjects: IN03126
Epigraphia Zeylanica
Eppāvaḷa
Eppawala

description: IN03126 Eppāvaḷa Slab Inscription 2 - Transcript and Translation Source: Paranavitana, S. (1928-33). ‘No. 18. Two Inscriptions from Eppāvaḷa,’ Epigraphia Zeylanica 3, pp. 188–194.
A new eremophilane glycoside from the fruits of Physalis pubescens and its cytotoxic activity
Creators: name: Xia, Guiyang
name: Huang, Yiyuan
name: Xia, Meijuan
name: Wang, Liqing
name: Kang, Ning
name: Ding, Liqin
name: Chen, Lixia
name: Qiu, Feng
Publisher: name: Taylor & Francis
Year: 2017
Subjects: Biochemistry
Medicine
Pharmacology
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Physalis pubescens L. has been used as a traditional folk medicine in China. Comprehensive studies aimed at identifying the bioactive constituents are still lacking. In the course of searching bioactive secondary metabolites from P. pubescens L., phytochemical investigation of the fruits of P. pubescens L. led to the isolation of one new eremophilane glycoside, 1β,3α-dihydroxy-7α-eremophila-911-dien-3-O-[α-L-arabinopyranosyl-(l→6)]-β-D-glucopyranoside (1), and six known glycosides (2–7). Their structures were established via extensive spectroscopic data including 1D and 2D NMR and HRESIMS. Cytotoxic effects against six human cancer cell lines (C4-2B, A375, A375-S2, 786-O, Caki-2, and ACHN) and one human normal hepatic cell line (L02) were evaluated and compounds 1 and 2 exhibited moderate cytotoxicity against C4-2B and A375 cell lines with IC50 values in the range of 6.78–28.3 μM. The study indicates that the fruits of P. pubescens L. have the potential to be used for drug discovery.
Mass spectrometry-guided isolation of two new dihydrobenzophenanthridine alkaloids from Macleaya cordata
Creators: name: Qing, Zhi-Xing
name: Yang, Peng
name: Yu, Kun
name: Yang, Xue-Yi
name: Liu, Jing-Hong
name: Xiang, Feng
name: Cao, Hua-Liang
name: Cheng, Pi
name: Zeng, Jian-Guo
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: Two new alkaloids 6-hydroxyethyldihydrochelerythrine (1) and 6-hydroxymethyl-7,8-demethylenedihydrochelerythrine (2) together with two analogues named maclekarpine E (3) and 6-hydroxymethyldihydrosanguinarine (4) were detected primarily from the leaves of Macleaya cordata by their characteristic mass spectrometry (MS) and tandem mass spectrometry (MS/MS). And then isolation of four targeted-compounds was performed by column chromatography and preparation HPLC under the guiding of MS. Finally, their structures were determined by spectrum analysis. Alkaloids 3 and 4 were isolated from this plant medicine for the first time.
Fractionation, amino acid profiles, antimicrobial and free radical scavenging activities of Citrullus lanatus seed protein
Creators: name: Dash, Priyanka
name: Goutam Ghosh
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified

description: In the present study, a modified Osborne fractionation method was followed to isolate albumin (Calb), globulin (Cglo), prolamin (Cpro) and glutelin (Cglu) successively from seeds of Citrullus lanatus (watermelon). This research work was undertaken to investigate the antimicrobial and antioxidant activities of isolated protein fractions of C. lanatus seed. Amino acid composition and molecular weight distribution were determined to establish their relationship with antimicrobial and antioxidant activity. Among all the fractions, Cpro was found to be most effective against A. baumannii followed by Calb and Cglo. The results showed that growth of inhibition of these protein fractions differ significantly from each other (p ≤ 0.05). In view of antioxidant potential, Cglo exhibited strongest antioxidant capacity while Cglu showed weakest antioxidant potential.
Hepatotoxicity of Eupatorium adenophorum extracts and the identification of major hepatotoxic components
Creators: name: Liu, Boyan
name: Cao, Lili
name: Zhang, Lijun
name: Yuan, Xiaofan
name: Zhao, Bing
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Eupatorium adenophorum can induce liver toxicity in animals. For the safe utilisation of the weed, the hepatotoxic components need to be discovered. In this study, in vitro hepatotoxicity of different extracts from E. adenophorum were determined on human hepatocyte cell line L02 and hepatocellular carcinoma cell line HepG2. The results showed that water extracts of E. adenophorum exhibited no hepatotoxicity in vitro while high concentrations of the organic solvent extracts had obvious hepatotoxicity. Sesquiterpenes may contribute to the toxicity based on the comparison of composition analysis. Three cadinene sesquiterpenes were purified and identified as 9-oxo-10,11-dehydroageraphorone, 10Hα-9-oxo-ageraphorone and 10Hβ-9-oxo-ageraphorone. In vitro hepatotoxic effects of these components were investigated, the IC50 of the three compounds were 122.53, 87.52, and 108.80 μM in L02 cells and 151.92, 104.48, and 138.08 μM in HepG2 cells by Cell Counting Kit-8 (CCK-8) assay. The three components were confirmed to be, at least partial, hepatotoxic components.
title: Insights into the application of chitosan as an anti-leishmanial compound.
Creators: name: Riezk, A
Publisher: name: London School of Hygiene & Tropical Medicine
Year: 2020

description: There is an urgent need for safe, efficacious, affordable and field-adapted drugs for the treatment of cutaneous leishmaniasis, a disease which affects around 1.5 million people worldwide every year. Chitosan, a biodegradable cationic polysaccharide, has previously been reported to have antimicrobial, anti-leishmanial and immunostimulatory activities. The work described here found that chitosan and its derivatives were approximately 7-20 times more active in vitro against Leishmania promastigotes and amastigotes at pH 6.5 than at pH 7.5, with high molecular weight chitosan being the most potent. Despite the in vitro activation of bone marrow macrophages by chitosan to produce nitric oxide and reactive oxygen species, this work showed that the anti-leishmanial activity of chitosan was not mediated by these metabolites. It was subsequently shown that rhodamine-labelled chitosan is taken up by pinocytosis and accumulates in the parasitophorous vacuole of Leishmania-infected macrophages. The application of chitosan in drug delivery systems was then studied by preparing two types of chitosan nanoparticles (positive (with tripolyphosphate sodium (TPP)) and negative (with dextran sulphate) surface charge with different sizes) and incorporation of amphotericin B within these nanoparticles. These amphotericin B-loaded nanoparticles demonstrated a good in vitro anti-leishmanial activity, similar to pure amphotericin B, and were also significantly less toxic than pure amphotericin B. The positive amphotericin B-loaded chitosan-TPP nanoparticles showed promising in vivo efficacy against cutaneous leishmaniasis caused by L. major in the BALB/c mouse model, via the intravenous route, and they were more active than AmBisome®. The impact of an in vitro media perfusion system on host cell phagocytosis and macropinocytosis was evaluated as well as the anti-leishmanial activity of chitosan solution and blank or amphotericin B-loaded chitosan-TPP nanoparticles. There was a significant difference between in vitro static and flow culture systems in the cell uptake and anti-leishmanial activity of the studied compounds.
Phytotoxic, antibacterial, and antioxidant activities of mycotoxins and other metabolites from Trichoderma sp.
Creators: name: Zhang, Ju-cheng
name: Chen, Guang-Yi
name: Li, Xiao-Zhan
name: Hu, Ming
name: Wang, Bang-Yan
name: Ruan, Bao-Hui
name: Zhou, Hao
name: Zhao, Li-Xing
name: Zhou, Jun
name: Ding, Zhong-Tao
name: Yang, Ya-Bin
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: A new natural mycotoxin was isolated from the fermentation broth of Trichoderma sp. Jing-8 and the structure was determined as alternariol 1′-hydroxy-9-methyl ether (1), together with twelve known compounds. The structures were elucidated on the basis of their 1D, 2D NMR spectra and mass spectrometric data. Compounds 1, 8 and 9 indicated inhibitions against germination of the seeds of cabbage with MICs < 3 μg/mL. The compound 1 showed the antibacterial activity against Bacillus subtilis and Staphylococcus aureus with MICs at 64 μg/mL. Compound 1 and 3 showed significant DPPH radical-scavenging activities with IC50 at 12 μg/mL, respectively. The OH at C-1′ in compound 1 decreased the cytotoxicity of these mycotoxins. A primary structure–activity relationship about the alternariol derivatives was discussed. Compounds 2–7 and 8 were the first time to be isolated from the Trichoderma.
Star-shaped discotic compounds with tetrazole and oxadiazole fragments
Creators: name: Usol'tseva, Nadezhda V.
name: Akopova, Olga B.
name: Smirnova, Antonina I.
name: Kovaleva, Maria I.
name: Bumbina, Natalia V.
name: Zharnikova, Nataliia V.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology

description: Two series of star-shaped discotic compounds (A and B) were studied to establish the relationship between their molecular structure and mesogenity. Series A included 19 three-arm compounds with known mesomorphism. Series B consisted of 132 new compounds with unknown mesomorphism: pyromellitic and cyanuric acid derivatives, 5,5′-azo-bis-isophthalic and 4,4′-azodiphthalic acids and triphenylene derivatives. The columnar mesomorphism prediction data for both series were obtained using the original program СМР ChemCard. The prediction data for series A are in good agreement with the experimental results and the reliability of the prediction was estimated to be 89.5%. The same method was applied for series B. The prediction results were approved by the synthesis of individual representatives of series B. A good correlation of the prediction with the experimental data was revealed.
O IMPACTO PSICOLÓGICO DE UMA FERIDA CRÔNICA EM PACIENTE COM PÉ DIABÉTICO: RELATO DE EXPERIÊNCIA
Creators: name: Bruna Sobral FERREIRA
name: Sara Bastos dos SANTOS
name: Glaucya Wanderley Santos MARKUS
Publisher: name: Zenodo
Year: 2024
Subjects: Diabetes Mellitus
Lesão Crônica
Emocional do paciente

description: RESUMO

 

O Diabete Mellitus (DM) é uma doença crônica não transmissível, caracterizada por hiperglicemia. Tem como sintomas: poliúria, polidipsia, perda de peso, polifagia e visão turva. O diabetes acomete muito o psicológico do paciente, principalmente em relação a se sentir excluído de tudo, devido às feridas crônicas. O estudo trata-se de relato de experiência desenvolvido por graduandas de enfermagem da IESC-FAG durante seus campos de estágio. Vê-se a necessidade de o enfermeiro realizar uma avaliação e cuidados específicos para o tratamento da ferida em pacientes com diabetes mellitus devido a sua dificuldade de cicatrização com a hiperglicemia.
A new sesquiterpene lactone from fungus Eutypella sp. D-1
Creators: name: Zhou, Yue
name: Zhang, Yi-Xin
name: Zhang, Jian-Peng
name: Yu, Hao-Bing
name: Liu, Xiao-Yu
name: Lu, Xiao-Ling
name: Jiao, Bing-Hua
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified

description: We isolated and identified a new sesquiterpene lactone which we named eut-Guaiane sesquiterpene (1), along with four cytochalasins from the fungus Eutypella sp. derived from the soil of high latitude of Arctic. The new structure was determined by spectroscopic studies such as 1D and 2D NMR and MS analyses, while the known compounds were identified by comparison of the NMR data with those in literatures. New compound 1 exhibited strong antibacterial activity against Escherichia coli, Bacillus subtilis and Staphylococcus aureus. Besides, it showed a little cytotoxicity against SGC7901 cell line.
Peniproline A, a new 1-phenylamino-2-pyrrolidone metabolite from the endophytic fungus Penicillium decumbens CP-4
Creators: name: Wang, Xiang
name: Li, Jun
name: Yu, Shui
name: Ye, Li
name: Feng, Meiqing
name: Li, Jiyang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: One new (named peniproline A, 1) and 11 known compounds were isolated from a culture of the endophytic fungus Penicillium decumbens CP-4. The structure of 1, featuring a phenylamine unit coupled with 2-pyrrolidone by forming a distinctive nitrogen-nitrogen bond, was elucidated based on extensive spectroscopic methods. Compound 1 was found to have cytotoxic effects against Bel-7402 and Hela cell lines with IC50 values of 8.1 and 15.5 μM, respectively.
ТУРЛ И ИҚЛИМ ШАРОИТЛАРИДА АТМОСФЕРА ҲАВОСИДАН ИЧИМЛИК ЁКИ ТЕХНИК СУВ ОЛИШ УСУЛЛАРИ
Creators: name: Максудов, Хусниддин
Publisher: name: Zenodo
Year: 2025

description: Турли иқлим шароитларида атмосфера ҳавосидан сув олиш учун бир нечта турдаги мосламалар ва технологиялар қўлланилади [1]. Бу мосламаларнинг ишлаш принципи ва самарадорлиги ҳавонинг намлиги, ҳарорати ва бошқа омилларга боғлиқ бўлади [2].
title: 01_1644
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Ultra high performance liquid chromatography with tandem mass spectrometry for rapid separation and identification of main constituents in Chinese herbal formula Xuan Hu Suo San
Creators: name: Tang, Huaqi
name: Zhang, Xinyue
name: Luo, Shilin
name: Shang, Fei
name: Chen, Jianping
name: Wang, Jinghong
name: Duan, Xiaojie
name: Gao, Xiaoyan
name: Sun, Yikun
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Xuan Hu Suo San (XHSS) is a traditional Chinese medicine that has been extensively applied in the treatment of osteoarthritis for many years, however, its chemical composition has not yet been elucidated. Thus, a rapid, efficient, and precise method based on ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was applied in both positive- and negative-ion modes to rapidly separate and identify the main chemical ingredients in XHSS for the first time. Finally, with the optimised separation and detection method, a total of 57 compounds were simultaneously separated within 13 min, among which 14 compounds were confirmed by comparing retention time and MS data with reference standards and others were tentatively identified by comparing with reference literatures. This rapid and sensitive approach is highly useful for the identification and characterisation of chemical constituents, and provides fundamental and extensive information supporting further metabolic and pharmacokinetic studies of XHSS.
Persistence with rapid-acting insulin and its association with A1C level and severe hypoglycemia among elderly patients with type 2 diabetes
Creators: name: Sambamoorthi, Usha
name: Garg, Rahul
name: Arijita Deb
name: Fan, Tao
name: Boss, Anders
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Neuroscience
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objective: To examine the persistence with rapid-acting insulin (RAI) and its association with clinical outcomes among elderly patients with type 2 diabetes (T2D). Methods: This observational, retrospective cohort study analyzed RAI persistence and its association with change in glycated hemoglobin A1c and risk of severe hypoglycemia among elderly (≥65 years) Medicare beneficiaries with T2D who added RAI to their basal insulin regimen. Results: Among T2D patients with >1 RAI prescriptions (n = 3927), only 21% were persistent. Baseline factors positively associated with RAI persistence (adjusted odds ratio [95% CI]) were: age ≥75 vs. 65–74 years: 1.20 (1.01–1.43); use of ≥3 oral antidiabetes drugs: 1.63 (1.16–2.28); cognitive impairment: 1.34 (1.03–1.73); and A1C >9.0%: 1.58 (1.15–2.17). Elderly T2D patients having emergency department visits (0.73 [0.59–0.91]) and higher RAI out-of-pocket costs (≥$75 vs. $0 – Conclusion: Among elderly T2D patients, persistence with RAI added to basal insulin was associated with improved glycemic control and lower risk of severe hypoglycemia. Despite treatment effectiveness, RAI persistence was poor and might be improved by reducing RAI out-of-pocket costs.
The GRASS GIS temporal framework
Creators: name: Gebbert, Sören
name: Edzer Pebesma
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: The availability of continental and global-scale spatio-temporal geographical data sets and the requirement to efficiently process, analyse and manage them led to the development of the temporally enabled Geographic Resources Analysis Support System (GRASS GIS). We present the temporal framework that extends GRASS GIS with spatio-temporal capabilities. The framework provides comprehensive functionality to implement a full-featured temporal geographic information system (GIS) based on a combined field and object-based approach. A significantly improved snapshot approach is used to manage spatial fields of raster, three-dimensional raster and vector type in time. The resulting timestamped spatial fields are organised in spatio-temporal fields referred to as space-time data sets. Both types of fields are handled as objects in our framework. The spatio-temporal extent of the objects and related metadata is stored in relational databases, thus providing additional functionalities to perform SQL-based analysis. We present our combined field and object-based approach in detail and show the management, analysis and processing of spatio-temporal data sets with complex spatio-temporal topologies. A key feature is the hierarchical processing of spatio-temporal data ranging from topological analysis of spatio-temporal fields over boolean operations on spatio-temporal extents, to single pixel, voxel and vector feature access. The linear scalability of our approach is demonstrated by handling up to 1,000,000 raster layers in a single space-time data set. We provide several code examples to show the capabilities of the GRASS GIS Temporal Framework and present the spatio-temporal intersection of trajectory data which demonstrates the object-based ability of our framework.
New adapiform primate fossils from the late Eocene of Egypt
Creators: name: Seiffert, Erik R.
name: Boyer, Doug M.
name: Fleagle, John G.
name: Gunnell, Gregg F.
name: Heesy, Christopher P.
name: Perry, Jonathan M. G.
name: Sallam, Hesham M.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Caenopithecine adapiform primates are currently represented by two genera from the late Eocene of Egypt (Afradapis and Aframonius) and one from the middle Eocene of Switzerland (Caenopithecus). All are somewhat anthropoid-like in several aspects of their dental and gnathic morphology, and are inferred to have been highly folivorous. Here we describe a new caenopithecine genus and species, Masradapis tahai, from the ~37 million-year-old Locality BQ-2 in Egypt, that is represented by mandibular and maxillary fragments and isolated teeth. Masradapis is approximately the same size as Aframonius but differs in having a more dramatic distal increase in molar size, more complex upper molar shearing crests, and an exceptionally deep mandibular corpus. We also describe additional mandibles and part of the orbit and rostrum of Aframonius which suggest that it was probably diurnal. Phylogenetic analyses place Masradapis either as the sister taxon of Aframonius (parsimony), or as the sister taxon of Afradapis and Caenopithecus (Bayesian methods). Bayesian tip-dating analysis, when combined with Bayesian biogeographic analysis, suggests that a common ancestor of known caenopithecines dispersed to Afro-Arabia from Europe between 49.4 and 47.4 Ma, and that a trans-Tethyan back-dispersal explains Caenopithecus’ later presence in Europe. For Masradapis: https://www.zoobank.org/urn:lsid:zoobank.org:act:41BC8459-7CCE-487F-BC59-1C34257D5C4E For Masradapis tahai: https://www.zoobank.org/urn:lsid:zoobank.org:act:C0A620AD-6FCA-4649-A980-FCA237AFE39D
A new azadirachta from the crude extracts of neem (Azadirachta Indica A. Juss) seeds
Creators: name: Gao, Quan
name: Sun, Jia
name: Xun, Hang
name: Yao, Xi
name: Wang, Jin
name: Tang, Feng
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: One new compound, 2H, 3H-cyclopent[b] furo [2′,3′:4,5] naphtho [2,4-d] heptlactone-[3,7] furan-6aceticacid, 3-(acetyloxy)-8-(3-furyl)-2a, 4a, 4b, 4c,5,5a, 6, 6a, 8, 9,9a, 10a,10b-13 hydrogen-2a,5a,6a,5-tetramethyl-3-[[(2E)-2-methyl-1-oxo-2-butenyl]oxy]-methyl ester, named azadirachta R (1), along with 10 known ones, Azadirachta A, AZ-B, AZ-D, AZ-H, AZ-I, nimbin, deacetylnimbin, salannin, deacetylsalannin and azadiradione were isolated from the crude extracts of neem (Azadirachta indica A. Juss) seeds, which were determined by UV, IR, HR-ESI–MS and NMR data analyses. According to the in vitro antibacterial activity experimental results, this compound showed good antibacterial activity to two bacteria, the minimum inhibitory concentration and the minimum bactericidal concentration of compound 1 to two kinds of bacteria are 50 and 25 mg/L, respectively, which were determined by resazurin colour-micro-dilution method. The experimental results provide a theoretical basis for the comprehensive utilisation of azadirachtin compounds in the future.
Genetic analysis of non-syndromic familial multiple supernumerary premolars
Creators: name: Bae, Doo Hwan
name: Lee, Ji Hyun
name: Song, Je Seon
name: Han-Sung Jung
name: Choi, Hyung Jun
name: Kim, Ji Hun
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 60506 Virology

description: Objective: Supernumerary teeth, a term describing a condition where patients have an abnormally large number of teeth, can be associated with non-syndromic or syndromic phenotypes. PDGFRs are cell surface tyrosine kinase receptors, and are involved in several aspects of tooth development. The purpose of this study was to identify causative genes of familial supernumerary teeth and the molecular pathogenesis of tooth number abnormalities through genetic analysis of a family that showed supernumerary premolars in two successive generations. Material and methods: We recruited a Korean family with supernumerary premolars and performed mutational analyses to identify the underlying molecular genetic aetiology. Results: Targeted exome sequencing identified a missense mutation in PDGFRB (c.C2053T, p.R685C). Sanger sequencing confirmed that three affected individuals in the patient’s family were heterozygous for the mutation. Conclusions: This is the first report of a Korean family that carries a PDGFRB mutation potentially responsible for supernumerary premolars. Our results demonstrate the power of next-generation sequencing in rapidly determining the genetic aetiology of numerical tooth abnormalities.
Persistence with rapid-acting insulin and its association with A1C level and severe hypoglycemia among elderly patients with type 2 diabetes
Creators: name: Sambamoorthi, Usha
name: Garg, Rahul
name: Arijita Deb
name: Fan, Tao
name: Boss, Anders
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Neuroscience
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objective: To examine the persistence with rapid-acting insulin (RAI) and its association with clinical outcomes among elderly patients with type 2 diabetes (T2D). Methods: This observational, retrospective cohort study analyzed RAI persistence and its association with change in A1C and risk of severe hypoglycemia among elderly (≥65 years) Medicare beneficiaries with T2D who added RAI to their basal insulin regimen. Results: Among T2D patients with >1 RAI prescriptions (n = 3,927), only 21% were persistent. Baseline factors positively associated with RAI persistence (Adjusted Odds Ratio [95% CI]) were: age ≥75 vs 65–74 years: 1.20 [1.01‒1.43]; use of ≥3 oral antidiabetes drugs: 1.63 [1.16‒2.28]; cognitive impairment: 1.34 [1.03‒1.73]; and A1C >9.0%: 1.58 [1.15‒2.17]. Elderly T2D patients having emergency department visits (0.73 [0.59‒0.91]) and higher RAI out-of-pocket costs (≥$75 vs $0 to Conclusion: Among elderly T2D patients, persistence with RAI added to basal insulin was associated with improved glycemic control, with lower risk of severe hypoglycemia. Despite treatment effectiveness, RAI persistence was poor and might be improved by reducing RAI out-of-pocket costs.
Investigating the chemical constituent and the suppressive effects of alliin hydrolysate on E.coli
Creators: name: Wu, Tao
name: Chen, Ning
name: Liu, Chang
name: Liu, Rui
name: Zhang, Jiaojiao
name: Xie, Xuan
name: Zhang, Min
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Virology

description: The present study investigates the antimicrobial activity of alliin degradation products by enzymatic and alkali-heat treatment. The results suggested that the suppressive effect of enzymatic degradation products (AE) on Escherichia coli was much higher than alkali-heat treatment products (AA). Both AE and AA seriously destroyed the integrity of E. coli cell membrane, decreased the utilisation of intracellular proteins and the absorption of extracellular phosphorus. Furthermore, GC-MS analysis preliminarily confirmed that alliin degradation products contained a variety of sulphur compounds, such as allyl disulphide and dithiene. The antibacterial activities exhibited by AE demonstrate their potential for use as E. coli inhibitor in food.
Supplementary figure and table from Diverse integrin adhesion stoichiometries caused by varied actomyosin activity
Creators: name: Bulgakova, Natalia A.
name: Wellmann, Jutta
name: Brown, Nicholas H.
Publisher: name: The Royal Society
Year: 2017
Subjects: Cell Biology
Developmental Biology

description: Cells in an organism are subjected to numerous sources of external and internal forces, and are able to sense and respond to these forces. Integrin-mediated adhesion links the extracellular matrix outside cells to the cytoskeleton inside, and participates in sensing, transmitting and responding to forces. While integrin adhesion rapidly adapts to changes in forces in isolated migrating cells, it is not known whether similar or more complex responses occur within intact, developing tissues. Here, we studied changes in integrin adhesion composition upon different contractility conditions in Drosophila embryonic muscles. We discovered that all integrin adhesion components tested were still present at muscle attachment sites (MASs) when either cytoplasmic or muscle myosin II was genetically removed, suggesting a primary role of a developmental programme in the initial assembly of integrin adhesions. Contractility does, however, increase the levels of integrin adhesion components, suggesting a mechanism to balance the strength of muscle attachment to the force of muscle contraction. Perturbing contractility in distinct ways, by genetic removal of either cytoplasmic or muscle myosin II or eliminating muscle innervation, each caused unique alterations to the stoichiometry at MASs. This suggests that different integrin-associated proteins are added to counteract different kinds of force increase.