cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Targeting invadopodia in head and neck cancer metastasis
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Tobacco use is a main rick factor for head and neck squamous cell carcinoma (HNSCC).

 While localized HNSCCs have 70-90% cure rates, the median survival for metastatic HNSCCs is only 5-9 months. Therefore, there are urgent unmet needs to provide better prognostic markers for metastatic disease stratification and to develop effective therapies to prevent HNSCC metastasis.

 Degradation of extracellular matrix (ECM) is essential for cancer cell invasion and metastasis. Proteolytic activity is associated with increased metastasis and poor clinical outcome in HNSCC. However, numerous MMP inhibitors have failed in clinical trials of HNSCC cancer partially due to the anti-tumorigenic roles of MMPs in immune cells. Recent research shows that instead of using secreted MMPs, HNSCC tumor cells concentrate various matrix proteases, including MMPs, at specialized membrane protrusions termed invadopodia to carry out focal ECM degradation. The ability to concentrate proteases at focal points for ECM degradation differentiates invadopodia from other actin-based protrusions. This unique character presents a regulatory program to target invadopodia for anti-metastatic HNSCC therapy without affecting actin dynamics in normal cells and causing overall toxicity. However, the molecular mechanism to recruit and activate proteases at invadopodia in metastatic HNSCC tumor cells remains largely unexplored.

 In this pilot project, we aim to use an innovative new technology to identify novel proteins that promote matrix degradation and HNSCC tumor metastasis. The ultimate goal of this pilot project is to understand how invadopodia are assembled and regulated to degrade matrix and drive HNSCC tumor metastasis.

 Our proposed research has direct therapeutic implication. First, our research could identify novel proteins that promote HNSCC tumor invasion and metastasis. These candidate could serve as prognosis markers for HNSCC metastasis and patient long-term survival. Given the essential role of invadopodia in HNSCC tumor metastasis, our research will also identify effective molecular targets for anti-metastasis therapy in HNSCC.
The role of PKDs in atherosclerosis & coronary heart disease
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cardiovascular disease (CVD) is the number one cause of human morbidity and mortality in the developed world. Overwhelming evidence has pointed to a direct causal role of tobacco use in CVD progression. Many reports convincingly demonstrate that CVD is the greatest cause of smoking-related premature death. Atherosclerosis can be considered to be a vascular disorder resulting from a response to injury initiated by circulating factors, including nicotine, and leads to CVD. It has been shown that cigarette smoking promotes endothelial dysfunction and accelerates atherosclerosis. Continuous smoking impairs flow-mediated dilatation (FMD) of the brachial artery in a dose-dependent manner in healthy young adults. Altered FMD is a well-defined early marker for endothelial dysfunction. Critically, reduction of endothelium-dependent dilatation caused by smoking is reversible.

 Vascular endothelial cells (ECs) line the entire circulatory system and play an essential role in health and disease. The endothelium not only provides a physical barrier to control vascular permeability, it also releases a large number of vasoactive substances to regulate vascular tone and vessel wall remodeling. Endothelial dysfunction, the initiating step of atherosclerosis, causes enhanced recruitment and retention of pro-inflammatory macrophages and T lymphocytes and diminishes production of Nitric oxide (NO). Protein kinase D (PKD) has recently emerged as a family of serine/threonine kinases with important cardiovascular actions. Several studies suggest a critical role for PKD in vascular biology and in cardiac ischemia. Our preliminary studies showed that PKD activity controls endothelial NO synthesis. However, there is a lack of in vivo evidence for the role of PKD in ECs, as well as a lack of insight into mechanisms by which PKD affects vascular biology. Our proposed studies are to test our hypothesis that endothelial PKDs play a protective role in the setting of cardiac ischemia, and in the progression of atherosclerosis, through the regulation of NO production. Results obtained from our proposed study will increase our knowledge of the specific roles of PKD in ECs during myocardial ischemia and atherosclerosis. An in depth understanding of pathways regulated by PKD in ECs is likely to yield new therapeutic targets for smoking-related vascular disorders.
PSILCA database for Social Life Cycle Assessment: Worker hours vs. raw values approach
Creators: name: Springer, Sally
name: Wulf, Christina
name: Zapp, Petra
Publisher: name: Forschungzentrum Jülich
Year: 2024

description: openLCA.conf – the open openLCA LCA conference 2024, Berlin, Germany, 15 Apr 2024 - 16 Apr 2024
description: Social Life Cycle Assessments (S-LCA´s) can either be conducted with a database or without. Available databases, e.g., the Product Social Impact Life Cycle Assessment database (PSILCA), use activity variables. Worker hours as an activity variable are used to reflect the relative significance of a process. Within the S-LCA community they are an established measure, but at the same time criticized, e.g., for their lack of correlation between the number of hours worked and the impact of a unit process. Besides that, the variable is related to working conditions and thus restricted to workers as a stakeholder group, even though it is common to use it also for other stakeholders, e.g., the local community or society. To address these issues, GreenDelta, the developers of PSILCA, invented, next to the established PSILCA database relying on worker hours, a new PSILCA database approach, which calculates with raw values instead of an activity variable. It is using a direct quantification approach, which calculates the weighted average of the indicator raw values. Both PSILCA database approaches rely on the same economic and social data, but their handling in openLCA differs. The goal of this work is to present these differences as well as advantages and shortcomings. Besides method specifications for openLCA and PSILCA, a case study is used to generate knowledge. The differences of the database approaches affect the way of modeling of the product system by the practitioner of the study, i.e., there are different modelling requirements to ensure a correct calculation of results in openLCA. This implicates a consequence for the interpretation. In addition, the mathematical logic inside the software as well as the expression of results are different. Three major differences are identified. E.g., for the calculation with raw values, the amount of the reference flow in the output always has to equal “1 USD”. Second, (the same) social indicator flows must be added to every unit process. Third, the number of unit processes has an influence on the results. Neither of these aspects are advantageous nor adverse, but the knowledge about their existence is key to conduct a correct calculation. When it comes to the results, impact category specific medium risk hours are the unit in the worker hours approach. As the raw value approach uses the raw values directly in the calculation, the results are expressed in the initial unit of the indicator, e.g., % or USD. This analysis will be continued and expanded.
Drosophila neocardini Streisinger 1946
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila neocardini

description: neocardini Streisinger, 1946: 111. Type locality: Brazil, Amazonas, Teffé. HT M (AMNH). NT Distr.: Brazil, Mexico to Peru. Colombia (Amazonas (Leticia)). Refs.: Heed & Russel, 1971: 98.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 729, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
An Optimality-Theoretic Analysis of Lachmann's Law
Creators: name: Roberts, Philip
Publisher: name: No Publisher Supplied
Year: 2009

description: This thesis examines the phenomenon in the morpho-phonology of Latin known as Lachmann's Law, whereby certain past participles display an etymologically unexpected long vowel.  Kiparsky (1965) proposed a rule-based account of the Law which involved the insertion of a rule elsewhere than at the end of the derivation, so that it interacts opaquely with another rule.  I re-formulate Kiparsky's original analysis within the framework of Stratal OT, proposing a new constraint and characterising the change giving rise to Lachmann's Law as a re-ranking of the constraint on the stem level.  A factorial typology of the new constraint is offered.
Some Aspects of Prominence in Assamese and Assamese English
Creators: name: Mahanta, Shakuntala
Publisher: name: No Publisher Supplied
Year: 2001

description: This dissertation establishes the pattern of prominence in Assamese and Assamese English. It shows for the first time that Assamese exemplifies a left-to-right trochaic system with an iterative binary rhythm. However, this rhythmic profile is disturbed by the occurrence of closed syllables deemed to be heavy. To support our intuitive judgments of prominence in Assamese with acoustic evidence, we conducted some experiments on PRAAT (a computer software for speech analysis). In chapter 3, we report the preliminary experiments which reveal that the acoustic correlate of primary prominence could very well be syllable duration and a low tone. Moreover, our intuitive judgments of prominence were vindicated by the surface phonetic realization of the F0 contours in our acoustic experiments. In a sequence of two light syllables, a distinct low tone on the first light syllable indicated primary prominence. In a light and heavy sequence, the F0 contour manifested as a plateau, instead of a falling trough, indicating the assignment of prominence to the following heavy syllable. In addition, the syllable duration of the prominent syllable was consistently longer than the other syllable. The fact that vowel duration was not found to be a significant correlate of prominence in the language is not surprising, as vowel length is not phonemic in the language. However, a clear picture of the correlate of secondary prominence did not emerge. Our tentative hypothesis regarding acoustic correlates for prominence is: 1) Syllable duration, computed after eliminating variability dependent on utterance length. 2) Low tone associated on non-final feet, as the right edge of the word is associated with a high tone. In chapter 4, the pattern of prominence is analyzed within the framework of Optimality Theory. We rank a set of universal constraints, to arrive at an optimality theoretic grammar of the language. These constraints also help us to establish the prosodic typology of the language. The language seems to allow only moraic trochees, which consists of two types of feet, LL (two light syllables) and H (a single heavy syllable). This is ensured by a high ranked FEET TYPE TROCHAIC and FEET BINARITY. While rhythmic prominence is accounted for by the domination of PARSE SYLLABLE over ALL FEET LEFT. Partial sensitivity to syllable weight is accounted for by the undominated *CLASH over WSP. Chapter 5 takes a brief look at Assamese English. It shows that theprominence pattern of Assamese English is identical with that of Assamese, and the English vowel system is re-interpreted by the Assamese speakers to fall in line with that of Assamese.
Morphologically Governed Accent in Optimality Theory
Creators: name: Alderete, John D.
Publisher: name: No Publisher Supplied
Year: 1999

description: This dissertation examines the influence of morphological factors on stress and pitch accent.  Two basic types are recognized.  In root-controlled accent, inherent accent in a root overrides inherent affix accent; as a result, affixal accent is only realized in words with unaccented roots.  In affix-controlled accent, the presence of a particular affix triggers one of several accentual mutations in the stem:  deletion of accent (or a 'dominance effect'),insertion of an accent (often known as pre- or post-accentuation), and accent shift or 'flop'.I argue that these two types of accentual behavior,despite important differences, are united under the rubric of faithfulness constraints in Optimality Theory.  Root-controlled accent is a consequence of the privileged faithfulness status of roots over affixes, as has been shown in other empirical domains such as vowel harmony.  Affix-controlled accent is due to a novel type of constraint, anti-faithfulness,which evaluates a pair of morphologically related words and requires an alternation in the shared stem.The principal case of root-controlled accent studied in this dissertation is the Uto-Aztecan language Cupeño.  In addition, I show how the accentual systems of Japanese and Russian fall within the scope of root faithfulness constraints.  The study of these cases leads to a substantive restriction on the range of edge effects in accent systems, and clarifies a role for root accentedness in blocking morpho-accentual processes.A number of properties of affix-controlled accentual processes are identified and shown to follow from the anti-faithfulness thesis.  Affix-controlled accent is (I) morphologically triggered, (II) stem-mutating, and (III) grammar dependent.  (I-II) follow from the assumption that anti-faithfulness operates on related words:  forcing an alternation in a pair of words ensures that affix-controlled accent is morphological because it contrasts two word classes.  Furthermore, as a relation between words, anti-faithfulness only affects the interval of a word which occurs throughout a paradigm, namely the stem (II).  Finally, anti-faithfulness does not fully specify how a pair of words should differ accentually; its specific effects therefore depend on the larger grammar in which it is embedded (III).  Affix-controlled accent in Russian, Japanese, Cupeño, Limburg Dutch, and Aguaruna (Jivaroan) is investigated in a series of case studies.  I argue that anti-faithfulness constitutes an integrated theory of the diverse morpho-accentual phenomena found in these languages, explains the important differences between the accentual properties of roots and affixes, and establishes parallels with non-accentual affix-controlled phenomena.
Reduplication as Affixation in Paiwan
Creators: name: Tseng, Meylysa
Publisher: name: No Publisher Supplied
Year: 2003

description: In this thesis I investigate the morphological structure of reduplication in Northern Paiwan, a Formosan language of Southern Taiwan.  The main objective is to use Optimality Theory (OT), as first formulated by Prince and Smolensky (1993), to show that reduplication can be considered the same as affixation.  This is in support of Marantz (1982).I do this by first classifying reduplication into two classes: prefixing (Ca reduplication or CaRED) and suffixing (root reduplication or RtRED).  Factors determining these classes are phonological structure and semantics.  Phonologically, RtRED is dimoraic and copies all of its segments from the stem.  CaRED, on the other hand, is monomoraic with the vowel invariably surfacing as a.  I find that the more prototypical and commonly used reduplication, RtRED, also has the more prototypical semantic functions of reduplication.  CaRED, on the contrary, has more specialized meanings with a narrower distribution.  Next, I show that reduplication and affixation follow the same constraints.  Thus, suffixal reduplicants follow the same constraints as suffixes and prefixal reduplicants follow the same constraints as prefixes.  In addition, suffixes and prefixes can also follow constraints previously restricted to the domain of reduplication. One of the conclusions that come forth from the analysis is that templates are needed to describe Paiwan root reduplication.  This is in opposition to recent efforts by McCarthy (1997), Gafos (1998) and Spaelti (1999) to eliminate template constraints.  My analysis also needs to consider the word-final coda to be extraprosodic.  To do so, following Harris and Gussmann (1998), word final codas are reanalyzed as onsets.  In this way, word-final codas will not violate No-Coda.  In addition, I look at Max-BR and how it has no important role in analyses that require templates.  I also choose to work in Spaelti's (1999) lexical-surface (LS) framework, as opposed to McCarthy and Prince's (1995a) input-base-reduplicant (IBR) framework.  I motivate this by showing that the LS interface will solve all of the problems created by the IBR interface.  With this analysis arises one complete OT grammar which can be used to analyze both reduplicants and affixes.  In addition, included in the Appendix is a successful application of this grammar to Thao, another Formosan language.  This analysis shows how the grammar can handle word-internal codas and consonant clusters, both of which are abundant in Thao and missing in Paiwan.
Drosophila neomorpha Heed & Wheeler 1957
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila neomorpha

description: neomorpha Heed & Wheeler, 1957: 33. Type locality: Panama, Canal Zone, Barro Colorado I. HT M (USNM). NT Distr.: Mexico to Colombia (Valle del Cauca (Rio Raposo)), Trinidad. Refs.: Heed & Russel, 1971: 99.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 729, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Rhinobatidae Muller & Henle 1837
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Rajiformes
Rhinobatidae

description: Family Rhinobatidae Müller & Henle, 1837
Guitarfishes
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 48, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Dipturus Rafinesque 1810
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Rajiformes
Rajidae
Dipturus

description: Dipturus sp. 1
Luanah’s Skate
Local synonymy: White et al., 2018: 218, figs (PNG).
PNG voucher material: (5 spec.) ASIZ P0080720, female 249 mm TL, Astrolabe Bay, Madang Province, 5°20.13’ S, 145°49.68’ E, 608–610 m depth, 5 Oct. 2010; ASIZ P0080721, juvenile male 314 mm TL, off Madang, 5°01.27’ S, 145°50.21’ E, 502–529 m depth, 2 Oct. 2010; NTUM 10327, juvenile male 342 mm TL, east of Cape Croisiles, Madang Province, 4°52’ S, 145°50’ E, 610–620 m depth, 16 Dec. 2012; NTUM 10328, female 350 mm TL, north of Taviltae, Madang Province, 4°29’ S, 145°31’ E, 500–510 m depth, 17 Dec. 2012; NTUM 10329, juvenile male 342 mm TL, Dogreto Bay, West Sepik, 3°18’ S, 143°02’ E, 440 m depth, 22 Dec. 2012.
Remarks: First record of this family and genus from PNG. A new species currently being described based on this material.
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 50, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Drosophila nigrasplendens Pipkin 1964
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila nigrasplendens

description: nigrasplendens Pipkin, 1964: 217. Type locality: Panama, Panama, Cerro Campana, 2500 ft. LT M (USNM). NT Distr.: Colombia (Amazonas (Leticia)), Panama, Peru, Trinidad. Refs.: Pipkin et al., 1966: 147.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 729, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Effects of nicotine e-cigarette self-administration on addiction-like behaviors in rats
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The electronic cigarette (e-cig) industry generated over $2.5 billion in revenue in the United States last year and is predicted to pass traditional cigarette sales by 2023 and reach $50 billion worldwide by 2030. In 2014 in California, for the first time ever, the teen use of e-cigs surpassed the use of traditional cigarettes. This is a major concern for communities, researchers, healthcare professionals, and law-makers because there is very little research on the long-term health effects of e-cig use to inform policy. Does chronic nicotine e-cig use produce nicotine dependence and addiction-like behaviors? Does it increase oxidative stress and histopathological changes in the cardiopulmonary system? Does it facilitate the development of cancer? Do flavoring chemicals have toxic effects, or do they facilitate the acquisition of e-cig use and the transition to nicotine addiction in adolescents? Does it produce changes the brain? A critical problem for researchers is the lack of relevant animal models of e-cig use, which prevents us from answering these questions. To addres this issue, we have recently developed a novel animal model of nicotine e-cig vapor self-administration. However, we do not know what is the impact of chronic nicotine e-cig vapor self-administration on key neurobehavioral measures of nicotine addiction, and we do not know the impact of the other ingredients of electronic cigarettes. The overall goal of this proposal is to address these gaps in the literature using chronic nicotine e-cig vapor self-administration in male and female adolescent rats. Results from these studies will provide a preclinical model to evaluate the addictive potential of flavorings and other ingredients of e-cigs to complement human studies and inform users and policymakers. It will also identify the causal effects of chronic extended access to nicotine e-cig self-administration on the development of addiction-like behaviors and its impact on the brain. Results from these studies have the potential to rapidly impact multiple fields of research, including the cardiopulmonary, neuroscience, and experimental psychology fields. This model may also be particularly useful for investigating the neurobiology of nicotine addiction and developing new medications that seek to reduce nicotine dependence.
Definition of Essential Geodetic Variables (EGV): Contribution of Geodesy to Earth Observation, White Paper
Creators: name: Gruber, Thomas
name: Angermann, Detlef
name: Sánchez, Laura
Publisher: name: Global Geodetic Observing System (GGOS)
Year: 2025
Subjects: EGV
Essential Geodetic Variables
GGOS
Geodesy
Earth Observation

description: This document describes the concept being developed by the Global Geodetic Observing System (GGOS) for the definition of Essential Geodetic Variables (EGVs). Following the same arrangement of the Global Climate Observing System (GCOS) and the Global Ocean Observing System (GOOS) for the definition of the Essential Climate Variables (ECVs) and the Essential Ocean Variables (EOVs), respectively, we present a catalogue of 18 EGVs based on 54 geodetic products. The first step in this process is to build consensus within the international geodetic community on this catalogue and then to define the requirements for the geodetic products supporting the EGVs. This effort will also include the identification of responsible stewards for each EGV.

Community involvement is being facilitated through review by or consultation with the GGOS Science Panel, the GGOS Governing Board, the IAG Executive Committee and the key IAG components (Services, Commissions, Inter-Commission Committees, Projects). Following their feedback, a wider public review will be initiated, taking into account relevant stakeholders and the global geodetic community, to balance collective interests and secure international and interdisciplinary recognition.
Anacanthobatidae von Bonde & Swart 1923
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Rajiformes
Anacanthobatidae

description: Family Anacanthobatidae von Bonde & Swart, 1923
Legskates
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 51, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Sinobatis Hulley 1973
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Rajiformes
Rajidae
Sinobatis

description: Genus Sinobatis Hulley, 1973
Legskates
Sinobatis (subgenus of Anacanthobatis) Hulley, 1973: 153. Type species: Anacanthobatis borneensis, Chan, 1965, by original designation (also monotypic).
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 51, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Drosophila nigricincta Frota-Pessoa 1954
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila nigricincta

description: nigricincta Frota-Pessoa, 1954: 289.Type locality: Brazil, São Paulo, Cantareira, near São Paulo. HT M (MNRJ). NT Distr.: Brazil, Colombia (Magdalena (Sierra Nevada de Santa Marta)), Panama, Venezuela. Refs.: Hoenigsberg, 1995a: 87, 1995b: 177.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 729, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Determinants of Successful Aging Among Older HIV+ Persons
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: It is projected that by 2015, more than half of all HIV-infected individuals in the U.S. will be over the age of 50. Yet, little is known about HIV in the latter half of life; in particular, what factors (such as the avoidance of mental and emotional decline) are associated with successfully living with HIV into older age. Among HIV-uninfected individuals, research on successful aging has shown protective effects resulting from behavioral and biologic factors affecting response to stress and motivation, lifestyle dependent behavioral and environmental influences such as social interaction, and the influence of brain resilience in maintaining a healthy, well-functioning brain. Because the interaction of these various influences may be unique to the context of HIV as compared to those without HIV, we believe that a study into this topic is important. Within this research project, we will determine both the number of older HIV+ persons who are successfully aging according to research established criteria as well as the factors that may help us to best predict (and ultimately prevent) mental and emotional decline among older HIV+ persons. These data may provide the necessary preliminary evidence to support future studies with larger groups of older HIV+ persons and to study HIV+ persons and their ability to age successfully with HIV over time. Specifically, we will recruit and test 100 HIV+ persons in regards to thinking skills, emotional health, and daily functioning. Additionally, we will examine a large set of variables to try to find predictors of successful aging with HIV. These data will then be compared to existing data of 100 HIV-uninfected persons who have completed similar assessments of successful aging. We hope to identify factors that could help us to prevent mental and emotional decline in the large and growing population of older HIV+ persons. Once these factors are identified, future studies can be conducted to create ways to intervene and prevent the poor outcomes that occur among some older HIV+ persons.
Drosophila nigricruria Patterson & Mainland, in Patterson 1943
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila nigricruria

description: nigricruria Patterson & Mainland, in Patterson, 1943: 136. Type locality: Mexico, Jalisco, El Medinena. T A (AMNH). NT Distr.: Mexico to Argentina. Refs.: Wasserman & Wilson, 1957: 146.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 729, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Sinobatis Hulley 1973
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Rajiformes
Rajidae
Sinobatis

description: Sinobatis sp. 1
Papuan Legskate
Local synonymy: White et al., 2018: 220, figs (PNG).
PNG voucher material: (1 spec.) NTUM 10326, female 196 mm TL, northwest of Maman Island, Madang Province, 4°0’ S, 144°54’ E, 800–860 m depth, 24 Dec. 2012.
Remarks: First record of this family and genus from PNG. Morphologically similar to Sinobatis bulbicauda Last & Séret, 2008 from northwestern Australia but differs in some characters and in structure of NADH2 gene (G. Naylor, unpubl. data); adult specimens required to confirm identity.
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 51, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Comparison between a dynamic assessment procedure and the WMLS-R in distinguishing language abilities among Hispanic children in first grade
Creators: name: Spero, Jill Marie
Publisher: name: No Publisher Supplied
Year: 2012

description: Historically, educators have had significant difficulty assessing the needs of culturally and linguistically diverse (CLD) learners, especially when determining special education classification. Hispanic students seem especially vulnerable to schools’ traditionally inadequate means of assessing language ability in CLD students. Dynamic assessment is one approach that has been identified as promising in the development of more culturally competent evaluation procedures. The purpose of this dissertation was to compare a traditional language assessment to a dynamic assessment procedure in regard to their utility for identifying students at-risk for Speech or Language Impairment (SLI). Twenty-five Hispanic, bilingual first graders from an urban school district were administered a standardized measure of language (Woodcock-Munoz Language Survey-Revised) as a traditional indicator of language ability. Students scoring one standard deviation below the mean were labeled at risk for SLI classification, while those scoring at the mean or higher were deemed typically developing. All children then underwent a dynamic assessment of language ability involving a pretest, two 30-minute mediated learning experiences, and a posttest. Following dynamic assessment, both groups made significant improvements in story complexity and completeness, and did so to a comparable degree. Furthermore, 100% of students classified at risk for SLI by the standardized measure were deemed typically developing according to dynamic assessment. Consistent with previous dynamic assessment studies, the results indicate that reliance on a traditional, standardized measure of language to assess Hispanic students for SLI may underestimate their language abilities and, thus, increase the risk for special education classification. Further, dynamic assessment appears to be a valuable tool for discerning language differences from true language disorders in Hispanic children.  Both dynamic assessment and standardized measures of language may assess different aspects of language ability, which together may comprise a more reliable assessment strategy for identifying SLI in Hispanic children. Implications for the use of dynamic assessment in SLI evaluation and intervention are discussed in light of concerns about misclassification of CLD students. Additionally, implications for the role of school psychologists related to dynamic assessment are addressed.
Examining metastatic potential in mammary stem cells
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: In breast cancer, metastasis research has largely overlooked the contribution of the cell-of-origin. In humans, pregnancy-associated breast cancers represent some of the most lethal mammary tumors due to frequent metastasis. Mammary stem cells (MaSCs) increase dramatically during pregnancy suggesting a link between MaSCs and pregnancy-associated tumors. In addition, these MaSCs represent unique targets of oncogenic transformation in the adult mammary gland, distinct from more differentiated epithelial cells, and may be directly related to cancer stem cells (CSCs), a highly aggressive sub-population of cells present in some breast tumors.

 In this project experiments will determine the relationship between mammary stem cells induced during pregnancy and cancer stem cells present in some of the most lethal breast tumors, including pregnancy-associated cancers. First, we will examine whether mammary stem cells from pregnant mice are more likely to form aggressive breast cancers and metastasize. This will be tested by adding a mutant protein to mammary stem cells that allows them to grow tumors in the mammary glands of mice. We will then determine whether these tumors grow larger or metastasize more frequently than other similar cell types in the mammary gland. Additionally, we will analyze these tumors for expression of biomarker proteins commonly associated with different breast cancer sub-types in people to determine any relationship between mammary stem cells and a particular type of breast cancer. Next, we will explore whether pregnancy regulates breast cancer stem cells and determine the molecular underpinnings of this association. This will be done by examining the behavior of breast cancer stem cells from mice genetically engineered to grow breast tumors. We will determine how these cancer stem cells behave in mice with at least one completed pregnancy compared to mice that have never been pregnant. Finally, we will test whether a molecule, called integrin alpha-v/beta-3, is required by cancer stem cells to grow tumors and metastasize.

 These studies have the potential to re-shape our current understanding of epithelial cancer biology by determining the potential of MaSCs to contribute to breast CSCs and metastatic tumor cells. Additionally, these experiments may implicate MaSCs and the integrin alpha-v/beta-3 as critical players in pregnancy-associated breast cancer. From a therapeutic perspective, our findings may suggest that targeting integrin alpha-v/beta-3 ligand-binding or signaling will benefit breast cancer patients with pregnancy-associated tumors. In the long-term, results from these studies will open the door to future examination of signaling pathways critical to MaSC function in order to identify new therapeutic targets for combating aggressive breast cancers.
Torpedinidae Bonaparte 1838
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Rajiformes
Torpedinidae

description: Family Torpedinidae Bonaparte, 1838
Torpedo rays
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 51, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Drosophila orkui Brncic & Koref-Santibanez 1957
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila orkui

description: orkui Brncic & Koref-Santibanez, 1957: 69. Type locality: Peru, Cuzco, Saczihuaman. ST B?. NT Distr.: Colombia, Peru. Refs.: Brncic, 1957a: 801.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 729, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Responding to bullies
Creators: name: Marszalowicz, Elena Marie
Publisher: name: No Publisher Supplied
Year: 2012

description: School administrators are responsible for identifying and enforcing consequences for students involved in bullying situations. Many principals and other school administrators provide input in policies delineating consequences in schools’ codes of conduct. Given these roles, it is important to understand how these decisions are made. This paper delineates the factors that have the greatest influence on administrator’s preferred methods of responding to bullying incidents. Subjects were recruited through New Jersey professional associations comprised of principals, vice principals, supervisors, directors, assistant superintendents, superintendents, and chief school administrators. An electronic survey link was distributed to approximately 9,000 administrators. A total of 165 completed surveys were submitted.  To analyze the quantitative survey data, a priori frequency counts, t-tests, and logistic regressions were performed. A posteriori tests were also performed including a one-way ANOVA, independent samples t-tests, and review of the qualitative data.  Findings indicated that counseling was the most popular consequence selected in response to bullying incidents (41%). Next most popular was detention (30%), followed closely by suspension (27%). Logistic regression results reveal that participants who were presented with a physical bullying vignette were significantly more likely to respond punitively than those presented with a verbal or social bullying vignette. Findings also indicate that participants who were socially ostracized as children were significantly less likely to respond punitively. Frequency of these types of events was also a significant predictor. Based upon these findings, the investigator made training and practice recommendations for New Jersey school administrators. Training recommendations included training in response to relational aggression and effective use of non-punitive consequences. Practice implications included administrators making their decisions based on best practice and in consideration of prevention of future events rather than avoiding conflict or minimally following the code of conduct. Implications for future research in this area included looking at the decision making process of those who are in responsible for developing district-wide codes of conduct and investigating how personality characteristics influence disciplinary decision making.
Tetronarce Gill 1862
Creators: name: White, William T.
name: Ko'Ou, Alfred
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Torpediniformes
Torpedinidae
Tetronarce

description: Genus Tetronarce Gill, 1862
Pelagic torpedoes
Tetronarce Gill, 1862. Type species: Torpedo occidentalis Storer, 1843, by monotypy and original designation.
description: Published as part of White, William T. & Ko'Ou, Alfred, 2018, An annotated checklist of the chondrichthyans of Papua New Guinea, pp. 1-82 in Zootaxa 4411 (1) on page 51, DOI: 10.11646/zootaxa.4411.1, http://zenodo.org/record/1221878
Sewer facilities final report
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1970

description: The purpose of this Study is to develop feasiblealternative solutions to provide adequate sewerage facilities for all the municipalities within Bergen County for the study period (to the year 2010) and to recommend the best and most economical one for adoption by the Board of Chosen Freeholders as a master sewerage plan.
Exploring the model minority
Creators: name: Wiltshire, Alexandra Thuy-Tran
Publisher: name: No Publisher Supplied
Year: 2012

description: When Asian students are seen as the model minority, pressures to conform and meet high expectations combined with discrimination and harassment may serve to negatively influence how Asians view their school climate. The current study seeks to examine views of the school climate by Asians as a function of their majority/minority status in their schools, as well as variability within Asian subgroups. By examining the students’ perceptions of overall school climate, student respect, student friendship and belonging, students’ shaping of their environment, and student support and care by staff, this study seeks to empirically examine the notions that have been demonstrated largely theoretically and anecdotally. In addition, this study seeks to examine the moderating effects of ethnic composition of the school on Asian students’ perception of school climate. Data were collected from completion of the Developing Safe and Civil Schools School Community Survey (Elias, 2009), a self-report questionnaire. Participants consist of 10,401 sixth to twelfth grade students from 25 New Jersey public schools who were enrolled in the Developing Safe and Civil Schools (DSACS) Project, directed by Maurice J. Elias, Ph.D., during the years 2006-2007. A series of ANCOVA analyses were used to examine differences on aspects of school climate based on ethnicity, Asian subgroup, and ethnic composition of the school, while controlling for the effects of DFG. Asians held higher views than Blacks and Latinos on overall school climate, student friendship and belonging, and student respect. Asians had higher perceptions of students’ shaping their environment than Whites, Blacks, and Latinos. Asians had lower perceptions of student support and care by staff than Whites. Southeast Asians held higher views than East Asians on student support and care by staff. With regard to ethnic composition of school, non-White dominant schools had higher perceptions of overall school climate than White dominant schools. Asian dominant schools had higher views of student respect than White dominant schools. In non-White dominant schools, Asians held higher views on overall school climate than Asians in White dominant schools. Relationship of findings to the literature, limitations, and implications of the current study for practice and research are discussed.
Therapist as mother, and mother as therapist
Creators: name: Robinson, Laura Carter
Publisher: name: No Publisher Supplied
Year: 2012

description: This qualitative study explored the relationship between the professional and mothering lives of female psychoanalytic (psychodynamic) psychotherapists. Nine participants completed semi-structured telephone interviews containing questions about the mutual influence of the roles of mother and therapist and the worldview of participants. Participants ranged in age from 36-57, had an average of between 1 and 2 children, were working from 6-35 hours per week at the time of the study, and were recruited nationally. Data were analyzed using interpretive phenomenological analysis, which focused on participants’ unique narratives as well as themes that were common across participants. The 14 themes that emerged from the data were compiled into four master themes: 1) Motherhood changes everything; 2) Insight changes everything; 3) Therapists’ experiences of motherhood are complex; and 4) Therapists have a worldview that encompasses their parenting and professional lives. Findings demonstrated that, in this sample, psychoanalytic therapist-mothers are influenced in their maternal roles by their roles as therapists and are influenced in their roles as therapists by their maternal roles.  Results also suggested that psychoanalytic therapists and mothers have several qualities in common, and that there is a way of being in the world that is inherently psychoanalytic for these participants. The study is situated within the following literatures: the subjective experience of mothers; the role of the maternal in psychoanalytic thinking; the influence of work on motherhood and motherhood on work; the personal life of the therapist; personal qualities of psychoanalytic therapists; and psychoanalytic parenting. Further, this study is the first to explore these particular ideas with a sample of psychoanalytic therapists.
The relationship between self-efficacy beliefs and social-emotional competence in at-risk girls
Creators: name: Hamed, Heather M.
Publisher: name: No Publisher Supplied
Year: 2012

description: Little is known about the relationship between self-efficacy beliefs and social-emotional competence in ethnic minority middle school girls. These children face a number of challenges related to their minority status, peer relationships, school transition, and entry into adolescence. School psychologists have attempted to increase the chances of success among this population by trying to build their resilience. Unfortunately, there is little prior research on the relationship between protective factors such as self-efficacy, optimism, social skills, and pro-social classroom behaviors for this unique population. A goal of this study was to generate data that would appropriately inform social and emotional interventions. This study examined the relationship between self-efficacy beliefs and social-emotional competence in 16 at-risk 7th and 8th grade students over the course of one school year. A cross-lagged panel design determined the trajectory of change among self-efficacy beliefs and social-emotional competence variables over time. Crosstab and chi-square analyses examined relationships among variables on an individual level. The strongest relationships were found among the same variables over time, indicating that interventions should focus on a single skill set of concern for the greatest improvement in that skill set over time. Some data suggest a relationship between optimism and social-emotional competence, which would indicate that optimism interventions may be helpful in improving social-emotional competence for this population. Optimism may be necessary but not sufficient for improvement in social-emotional competence. Future research may benefit from examining these relationships across a longer period of time and examining how different cultural variables may impact our understanding of the relationship between self-efficacy beliefs and social-emotional competence.