cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Towards a Formal Total Synthesis of Triptolide Via a Gold-catalyzed Cyclization Cascade
Creators: name: Schwantje, Travis R.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Chemistry
organic
synthesis
triptolide
tripterygium
wilfordii
total synthesis
gold catalysis
cyclization
thunder god vine
natural product
terpenoid
gold

description: This thesis discusses the progress made towards a formal total synthesis of triptolide, a naturally occurring diterpenoid triepoxide molecule. Isolated from a Chinese vine, triptolide features some interesting structural characteristics and has demonstrated a broad range of interesting medicinal effects. It has demonstrated remarkable cytotoxicity against a number of cancer cell lines, immunosuppressive activity, and reversible male sterility. This biological activity has made it a target of a number of total syntheses spanning from 1980 to 2010. Gold-catalyzed transformations are an emerging field in synthetic organic chemistry, but their efficacy and potential uses are gaining much recognition among the synthetic organic community. Our research group is extremely interested in the applications of such gold-catalyzed organic transformations in natural product synthesis. Here, we discuss our investigations towards accessing the tetracyclic core of triptolide using a gold-catalyzed cyclization cascade reaction. We explored a number of synthetic routes towards a common linear precursor, and our successes and failures are discussed herein. We also report numerous unsuccessful efforts towards an oxidative gold-catalyzed cyclization cascade to form the tetracyclic core of triptolide. Finally, we investigated the use of a photocatalytic radical cyclization cascade to access the desired core. We report some promising preliminary results, and this study is ongoing in the Barriault group.
An examination of business leadership in Sri Lanka: Cultural modelling of sustainability leadership
Creators: name: Sumanasiri, Erabaddage Ayoma Gayathri
Publisher: name: Swinburne
Year: 2024

description: This research investigated sustainability leadership of Sri Lankan managers. Sri Lanka is a developing nation that aspires to achieve sustainable economic development. Managerial perceptions for sustainability help to achieve sustainable economic development. The diversity of sustainability definitions, issues, significance, and strategies are found to be context-specific. The research tested and developed an integrated cultural model to explain what constitutes sustainability leadership among Sri Lankan managers. A cross-sectional survey was conducted among Sri Lankan managers, the data analysed and implications for practice and knowledge identified.
Automatic Goal Clone Detection in Rocq
Creators: name: Ghanbari, Ali
Publisher: name: arXiv
Year: 2025
Subjects: subject: Programming Languages (cs.PL)
subject: FOS: Computer and information sciences

description: Proof engineering in Rocq is a labor-intensive process, and as proof developments grow in size, redundancy and maintainability become challenges. One such redundancy is goal cloning, i.e., proving α-equivalent goals multiple times, leading to wasted effort and bloated proof scripts. In this paper, we introduce clone-finder, a novel technique for detecting goal clones in Rocq proofs. By leveraging the formal notion of α-equivalence for Gallina terms, clone-finder systematically identifies duplicated proof goals across large Rocq codebases. We evaluate clone-finder on 40 real-world Rocq projects from the CoqGym dataset. Our results reveal that each project contains an average of 27.73 instances of goal clone. We observed that the clones can be categorized as either exact goal duplication, generalization, or α-equivalent goals with different proofs, each signifying varying levels duplicate effort. Our findings highlight significant untapped potential for proof reuse in Rocq-based formal verification projects, paving the way for future improvements in automated proof engineering.
description: 39th European Conference on Object-Oriented Programming (ECOOP 2025)
GGTI-298 in Combination with EGFR Inhibitors: Evaluating a Novel Therapy in Head and Neck Squamous Cell Carcinomas
Creators: name: Zahr, Stephanie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: head and neck cancers
head and neck squamous cell carcinomas
receptor tyrosine kinases
epidermal growth factor receptor
tyrosine kinase inhibitors
mevalonate pathway
statins
protein prenylation
geranylgeranylation
GTPase inhibitors

description: Overall survival of the metastatic forms of epithelial derived cancers, especially head and neck squamous cell carcinomas (HNSCC), has not significantly improved even with the application of aggressive combined modality approaches incorporating radiation and chemotherapy. Cumulative evidence implicates the epidermal growth factor receptor (EGFR) as an important therapeutic target in HNSCC. We have previously demonstrated that the combination of lovastatin, a potent inhibitor of the mevalonate pathway, with EGFR tyrosine kinase inhibitors induced robust synergistic cytotoxicity. However, the use of high dose statins in our clinical trial was associated with significant toxicities including higher than anticipated rate of muscle pathologies. Our goal was to uncover novel downstream targets of the mevalonate pathway that may enhance the efficacy or limit toxicities of this novel combination therapeutic approach. In this study we have demonstrated that GGTI-298, an inhibitor of protein geranylgeranylation, through its ability to disrupt the actin cytoskeleton, inhibits EGFR dimerization and cellular trafficking. This novel mechanism targeting the EGFR has clinical implications as GGTI-298 in combination with tarceva, a clinically relevant EGFR inhibitor, showed enhanced cytotoxicity and inhibitory effects on EGFR activation and its downstream signaling.
How parents understand their daughters behaviour before they receive a diagnosis of an autism spectrum condition.
Creators: name: Kseib, Natalie
Publisher: name: University of Surrey
Year: 2020
Subjects: Autism
Diagnosis
Females
Gender
Girls
High Functioning

description: Introduction: Prevalence studies show that fewer girls are diagnosed with Autism Spectrum Conditions (ASCs) than boys. This difference is particularly marked where there is no cognitive impairment. Some suggest that ASCs present differently between males and females, perhaps leading to delayed diagnosis in girls. A review of the literature exploring sex/gender differences found that many studies have measured the severity of ASC symptoms rather than the quality of difference. Limited research has considered the perspectives of parents on the signs noticed in their daughters and the context in which difference is noticed. Objective: This study sought to explore how parents make sense of their daughters’ behaviours and the processes by which behaviours are perceived as requiring intervention or diagnosis. Participants: Five parents whose daughters (aged 9-12 years) had recently received a diagnosis of an Autism Spectrum Condition without cognitive impairment were invited to tell their stories of diagnosis. Design: Transcripts were analysed using a narrative approach, focusing on how stories were told. Findings: Narrative themes were identified across transcripts in relation to the process by which behaviours are made sense of. Themes included: daughters only showing their ‘real self’ in safety; their distress peaking; parents questioning normality; and parents feeling blamed and unheard. Conclusions: The findings are discussed in relation to existing research and theory. Implications are discussed in relation to education and health services and UK policies. Further research into parents’ experience of judgement in relation to their child’s behaviour, and exploration of interventions for masking in girls is needed.
IL-7 Responses In Th17 Cells Are Dysregulated During HIV Infection
Creators: name: Stilla, Alana
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Th17 cells
IL-7
HIV infection
HAART
proliferation
Bcl-2
pSTAT5
CD127
Alana
Stilla
Jonathan
Angel

description: In the gut-associated lymphoid tissues, Th17 cells mediate mucosal homeostasis and inflammation. During HIV infection, Th17 cells become depleted and functionally impaired, which is implicated in the pathogenesis of chronic inflammation in patients treated with highly active antiretroviral therapy. IL-7 is a cytokine that mediates homeostatic responses in T lymphocytes, such as proliferation and survival, which are dysregulated during HIV infection. Whether similar dysregulation occurs in Th17 cells has yet to be reported. IL-7 receptor α (CD127) expression and IL-7 responses were therefore measured in blood-derived Th17 cells from uninfected individuals and effectively treated, HIV-infected individuals by flow cytometry. Th17 cells from uninfected individuals expressed CD127 and, in response to IL-7, exhibited phosphorylation of STAT5, upregulation of Bcl-2, and proliferation. During HIV infection, expression of CD127 and pSTAT5 in Th17 cells was comparable to that observed in cells from uninfected individuals. Interestingly, expression of Bcl-2 was upregulated while proliferation was dramatically impaired. These findings may provide further insight into the mechanisms by which Th17 cells fail to become restored during HIV infection.
Un modello cognitivo delle emozioni estetiche
Creators: name: Consoli, Gianluca
Publisher: name: Lebenswelt. Aesthetics and philosophy of experience.
Year: 2012

description: This essay proposes a cognitive model of aesthetic emotions. Their nature, forms, functions are explained on the basis of empirical and theoretical results of neurocognitive sciences about ordinary emotions, integrated with concepts selected from aesthetics. The proposed explanation confirms the essential role of aesthetic emotions in cultural learning and creation, dissolving the paradox of fiction.
description: Lebenswelt. Aesthetics and philosophy of experience., N° 2 (2012)
title: Roots to Antithesis
title: Diversity and collaboration in contemporary guitar works
titleType: Subtitle
Creators: name: Soukaras, Dimitrios
Publisher: name: University of Surrey
Year: 2024
Subjects: Keywords: Guitarist performer, creative role, collaboration with non-guitarists composers.

description: This research project aims to discuss the interaction between my role as the guitarist per-former in the creative process while collaborating with non-guitarists composers. The mainquestion governing this research is to identify how collaboration between the composersand myself impacts the notation, interpretation and identity of the new musical work. Thisresearch approaches a rarely explored perspective: focusing on the collaboration betweencomposers that do not play the instrument they are writing for. It is equally important to benoted that the project involves a variety of musical genres, inviting composers from Brazil,Australia/Taiwan, and Greece. There are five case studies: four with non-guitarists compos-ers and one comparative case study with a guitarist composer. Composers involved in theproject are Sergio Assad (1952), Belle Chen (1988), Petros Klampanis (1981), Iason Marou-lis (1999), and John Panagiotou (1995). The findings are intended to broaden the under-standing of contemporary collaborative practices in the compositional process for the guitar.The research material (commissioned works) will not only extend the guitar repertoire intonew and exciting territories but will also test the technical possibilities of the instrument andoffer a range of solutions to problems. This project involves proactive collaboration at allstages of the creative process.This thesis documents, contextualises and illuminates the collaborative albums Roots(Naxos International Records, 2021) and Antithesis (pending publication). Roots is availableon all online music platforms as well as in the Naxos Records catalogue. A link to the CDis available in appendix 10. Antithesis is expected to be released by Naxos within 2025.
Kant on formative power
Creators: name: Goy, Ina
Publisher: name: Lebenswelt. Aesthetics and philosophy of experience.
Year: 2012

description: In this paper, I present a novel interpretation of the notion 'formative power' in Kant's "Critique of the Power of Judgment" (§65). I defend the view that for Kant the formative power is a fundamental, immaterial, intrinsic natural power in the organized being. It is a final cause that generates the purposive form of the materials of an organized being. Reading God's creation as the primary and nature's formative power as a secondary final cause of the purposive form of nature allows us to see the consistency of Kant’s theological and philosophical views in the field of biology.
description: Lebenswelt. Aesthetics and philosophy of experience., N° 2 (2012)
A thesis of clinical research: Part A: Understanding the Gaps in Provision of Support Provided by Secondary Schools in Addressing Disordered Eating and Body Image: A UK Perspective. Part B: Young people, Food and Bodies. What can Schools do to Develop Healthy Relationships? A Focus Group Study.
Creators: name: Bodrell, Elizabeth
Publisher: name: University of Surrey
Year: 2024
Subjects: Child or Adolescent Mental Health
Eating Disorders
Education
Mental Health
School Food Programs
Teacher Attitude
Teacher Education

description: Incidences of obesity and disordered eating are rising throughout the population. Adolescence is a period of considerable change, where many of this issues manifest. Meanwhile, Schools provide a prominent place of possible intervention, as is being increasingly recognised by the government and policy makers. Limited studies have aimed to understand the perspectives on support for disordered eating and body image issues in UK secondary schools, from either teachers or students. Part one of this portfolio delves into the perspectives of teachers. Through a cross-sectional study employing self-report questionnaires, data was gathered on school policies, teacher attitudes, knowledge, and motivation related to these critical issues. The findings underscore significant gaps in school policies, teacher training, and resources. While teachers expressed positive attitudes towards potential interventions, such as one-to-one support and staff training, they faced limitations in capability and opportunity to enact behavioural changes. The study emphasizes the necessity for targeted interventions in schools, advocating for increased staff training, clearer guidance, and the utilization of a whole-school approach to address disordered eating and body image concerns. Paper two investigates the perspectives of young people. Utilizing focus groups and reflexive thematic analysis, the study unveils four key themes: Breaking the silence, Going deeper, Diversity and balance, and More than a body. These themes illuminate the silencing experienced by young people, the impact of biased messages on food and bodies perpetuating societal norms, and the calls for more comprehensive conversations, media literacy, and self-esteem interventions. The study suggests interventions at various ecological levels, including targeting self-esteem, promoting healthier messages, combating stigma, and engaging in social activism. Implications for schools and broader social structures are discussed, emphasizing the importance of multifaceted approaches to support young people's mental health. Together, these studies underscore the urgency of addressing these critical issues within educational settings.
Le parole dell'arte. Ovvero quando l'opera, da sola, non basta
Creators: name: Rotili, Manrica
Publisher: name: Lebenswelt. Aesthetics and philosophy of experience.
Year: 2012

description: This paper moves from those works of art that include the killing, the ill-treatment and the use of dead animals and therefore it starts from the artifacts whose status of art is difficult to understand in order to discuss the role and power of the theory in the art world. It considers in particular the philosophy of art of Arthur Danto to reflect on the necessity of the relationship between work and interpretation in contemporary art. If the current art has earned (hardly) the freedom from formal constraints, from the ethical and aesthetic standards that until the avant-garde art have regulated the activity of the artist, this art turns out to be, at the same time, a kind of art even more dependent from an exegesis, from an explanation and an interpretation that have to shed light on its meaning, its purpose, its intention. Yet if it is true that what makes something a work of art is its relationship with the context formed by the history and by theory of art and if it is true that an interpretation that is based on this type of knowledge allows a physical object to be seen as a work of art, it is also true that the frames that appeal to history tend not to clearly define the "distinctive characteristics" of art, leaving unresolved, in essence, the question posed by the problem of the recognition criteria.
description: Lebenswelt. Aesthetics and philosophy of experience., N° 2 (2012)
La fenomenologia del volere: Husserl, Pfänder e Geiger
Creators: name: Ubiali, Marta
Publisher: name: Lebenswelt. Aesthetics and philosophy of experience.
Year: 2012

description: The will is one of the most consistent focuses of much of Husserl’s work beginning with the Logische Untersuchungen and continuing through his reflections in the 1930s. Any phenomenology of experience must account for the fact that every moment of our lives is marked by tension of will. Such a study, therefore, combines many important and interrelated issues, such as the problematic relationship between the voluntary and the involuntary sphere of the ego’s life. Over the history of the phenomenological movement, Husserl was not the only one to dedicate so much attention to the phenomenon of will. In addition to outlining Husserl’s phenomenology, this paper explores the phenomenological analyses of Alexander Pfänder and Moritz Geiger. In the wake of the traditional philosophical concept of the will, Pfänder considers the will as a dimension of pure activity and self-determination, whose peculiar trait is the so-called geistiger Schlag. Instead, Geiger points out the complexity of the voluntary dimension and advances the paradoxical hypothesis of the existence of a non-experienced will. Husserl moves deeper into this latter direction when he highlights the overall dimension of the will, which permeates the entire life of the ego even in the form of the Willenpassivität.
description: Lebenswelt. Aesthetics and philosophy of experience., N° 2 (2012)
Ultrafeine Partikel
Creators: name: Birmili, Wolfram
name: Elsasser, Michael
name: Gerwig, Holger
name: Hellack, Bryan
name: Juhrich, Kristina
name: Langner, Marcel
name: Liesegang, Christian
name: Nordmann, Stephan
name: Rüdiger, Julian
name: Straff, Wolfgang
name: Tobollik, Myriam
name: Vitzthum Von Eckstädt, Christiane
name: Wichmann-Fiebig, Marion
Publisher: name: Umweltbundesamt
Year: 2022
Subjects: subject: Ultrafeine Partikel
subject: UFP
subject: Quellen
subject: Partikelanzahl
subject: Partikelanzahlgrößenverteilung
subject: 10 nm
subject: 100 nm
subject: Luft
subject: Gesundheit

description: Dieser Text stellt den Stand und die Lücken des Wissens zu Ultrafeinen Partikeln aus regulatorischer Sicht dar. Obwohl bereits erste Schritte der Vereinheitlichung gemacht sind zeigt sich ein deutlicher Normungs-, Regelungs- und Untersuchungsbedarf. Quelle: Texte-Band
description: This text presents the state and gaps of knowledge on ultrafine particles from a regulatory perspective. Although the first steps towards standardisation have already been taken, there is a clear need for further standardisation, regulation and investigation. Quelle: Texte-Band
description: Dieser Text stellt den Stand und die Lücken des Wissens zu Ultrafeinen Partikeln aus regulatorischer Sicht dar. Obwohl bereits erste Schritte der Vereinheitlichung gemacht sind zeigt sich ein deutlicher Normungs-, Regelungs- und Untersuchungsbedarf.
Supplementary document for Optical memory effect in square multimode fibers - 5428072.pdf
Creators: name: Caravaca, Antonio
name: Carron, Adrien
name: Mezil, Sylvain
name: Wang, Irène
name: Bossy, Emmanuel
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Classical and Physical Optics

description: Supplemental document
Measuring powder flow at low stresses
Creators: name: Mahmoud, Azza Aly Mohamed
Publisher: name: University of Surrey
Year: 2024
Subjects: Powder flowability, Low-stress measurement techniques, Ball indentation, Shear cell

description: Powders are used in various industries, including paints, pharmaceuticals, and food, where their flow behaviour is crucial. It is vital to understand powder flow to avoid blockages and unreliable flow patterns out of hoppers. Shear cells are the most effective method for determining powder flowability under moderate stress, with applications in silos and hoppers. However, processes like powder dosing in capsules and dry powder inhalers involve low consolidation stresses (≤ 1 kPa), where shear testing for unconfined yield strength faces inconsistencies. Ball indentation (BI) has emerged as a solution for low-stress flowability assessment, estimating unconfined yield strength indirectly by measuring hardness. However, BI requires determining the powder's constraint factor, which represents the added resistance caused by the elastically deforming region surrounding the plastically deforming indentation zone. This work aims to optimise BI and validate shear cell testers under low-stress conditions. It explores various aspects of BI, including consolidation methods and bed preparation, with sieve-filling found to be the most effective. It investigates how indentation factors: position, indenter size, and penetration depth affect the powder constraint factor and yield stress. Flow properties of various powders were evaluated using various shear cell testers (FT4, RSTXS.s, RST-01.pc), with results varying based on material and stress conditions. Comparative analyses of these testers and BI, confirmed the effectiveness of both RST-XS.s and BI, under lowstress conditions. However, results from BI and RST-XS.s provided different flow functions for the same powder at similar stress levels. To validate these methods' applicability, two hoppers were designed, tailored to each method. The BI method successfully predicted the necessary outlet size to prevent arching, contingent on consistent filling methods (sieving) in both the hopper and indentation tests. While the RST-XS.s shear cell testing recommended larger outlet sizes which were effective irrespective of the filling method.
Distributed Representations Enable Robust Multi-Timescale Symbolic Computation in Neuromorphic Hardware
Creators: name: Cotteret, Madison
name: Greatorex, Hugh
name: Renner, Alpha
name: Chen, Junren
name: Neftci, Emre
name: Wu, Huaqiang
name: Indiveri, Giacomo
name: Ziegler, Martin
name: Chicca, Elisabetta
Publisher: name: ETH Zurich
Year: 2025
Subjects: Neural and Evolutionary Computing (cs.NE)
Artificial Intelligence (cs.AI)
FOS: Computer and information sciences

description: Programming recurrent spiking neural networks (RSNNs) to robustly perform multi-timescale computation remains a difficult challenge. To address this, we describe a single-shot weight learning scheme to embed robust multi-timescale dynamics into attractor-based RSNNs, by exploiting the properties of high-dimensional distributed representations. We embed finite state machines into the RSNN dynamics by superimposing a symmetric autoassociative weight matrix and asymmetric transition terms, which are each formed by the vector binding of an input and heteroassociative outer-products between states. Our approach is validated through simulations with highly nonideal weights; an experimental closed-loop memristive hardware setup; and on Loihi 2, where it scales seamlessly to large state machines. This work introduces a scalable approach to embed robust symbolic computation through recurrent dynamics into neuromorphic hardware, without requiring parameter fine-tuning or significant platform-specific optimisation. Moreover, it demonstrates that distributed symbolic representations serve as a highly capable representation-invariant language for cognitive algorithms in neuromorphic hardware.
description: arXiv
Rb-Sr Age Estimates of Pore Fluids in Sedimentary Rocks, DGR Site, Kincardine, Ontario
Creators: name: Bouchard, Laurianne
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Sedimentary rocks
Isotopes
Strontium
Rubidium
Porewater

description: This study is part of a project aiming for the long-term burying of nuclear wastes in Kincardine, Ontario. Bedrock formations as well as their associated waters were analyzed in drill cores from the Michigan sedimentary basin, southwest Ontario. This research utilizes geochemistry combined to strontium and rubidium isotope ratios in order to determine the origin of porewaters from Ordovician shales and limestones. It is demonstrated that these waters are the result of a mixing line between the Silurian (Guelph) and Cambrian groundwaters. This last end-member was also mixed with Precambrian brines to some extent. Strontium and rubidium isotopes also demonstrated rubidium in clays were leached by porewaters over time. Once in solution, radioactive rubidium decayed into strontium over time. This process explains the accumulation of radiogenic strontium observed in porewaters. An age estimate for the deposition of carbonates and other evaporates was calculated with the Rb-Sr isotope system. The calculated age is 453.7 million years before present for dolomites, which is consistent with the history of the site. It was possible to gen an approximate age of 339.7 million years for the formation of illites. This corresponds to the illitization process that occurred after the deposition of rocks, when the Silurian brines infiltrated the deeper Ordovician shale. It was also possible to estimate of porewaters ages.
Automated support for the elaboration and analysis of goal-use case integration models
Creators: name: Nguyen, Tuong Huan
Publisher: name: Swinburne
Year: 2024

description: Requirements engineering is the process of elaborating, analysing, and managing software requirements to ensure these requirements are of high quality (such as complete, consistent, correct). However, this goal is sometimes difficult to achieve in practice, causing project time and cost overrun, or even failure. This research is aimed at improving the quality of requirements and thereby, increase the chance of project success. Specifically, we target to provide an automated support for requirements engineers to elaborate and analyse requirements in a user-friendly manner. The proposed techniques allow requirements engineers to semi-automatically extract requirements models from natural languages documents, analyse such models for inconsistency, incompleteness, and incorrectness, and resolve detected problems if any.
Forum on John Hyman, "The objective eye"
Creators: name: Hyman, Ed. By S. Chiodo
name: Z. Adams, P. Spinicci, M. Budd, W. Davies,
Publisher: name: Lebenswelt. Aesthetics and philosophy of experience.
Year: 2012

description: ...
description: Lebenswelt. Aesthetics and philosophy of experience., N° 2 (2012)
Exploring the association between affective work-related rumination and cardiovascular risk factors
Creators: name: Steiner, Sarah
Publisher: name: University of Surrey
Year: 2020

description: Previous research has suggested that cardiovascular disease risk factors can be influenced by work-related stress, eliciting both psychological and physiological responses. These stress responses, and their subsequent effect on cardiovascular disease risk may be prolonged by an inability to adequately unwind from work. This thesis aims to explore the association between work-related rumination, focussing on affective rumination, and three modifiable cardiovascular risk factors: diet, blood lipids and blood pressure. Four studies were conducted. In study 1, findings from a four-day food diary study showed that affective rumination was significantly associated with emotional eating. Additionally, high affective ruminators (N = 18) consumed significantly more sugar, saturated and monounsaturated fats during weekdays relative to low affective ruminators (N = 16). In study 2, results from a cross-sectional designed study revealed a significant positive association between affective rumination and high-density lipoprotein (HDL) cholesterol. Moreover, high affective ruminators (N = 15) exhibited significantly higher levels of HDL cholesterol when compared to low affective ruminators (N = 14). Study 3 employed an explorative blood pressure diary design over four consecutive days (two workdays followed by two leisure days). Findings indicated significant negative associations between state affective rumination and systolic blood pressure and heart rate on workdays. There was no significant effect of trait rumination group (high [N = 32] vs. low [N = 30]) on blood pressure and heart rate. In study 4, results from a four-week randomised waitlist control study demonstrated that individuals assigned to the mindfulness meditation group (N = 28), reported significantly fewer somatic stress symptoms and higher levels of psychological detachment compared to controls (N = 33). Overall, findings propose that affective work-related rumination is associated with cardiovascular risk factors, namely diet, blood lipids and blood pressure. Mindfulness-based meditation provides an effective way to reduce somatic stress symptoms and improve psychological detachment.
Nonlinear longitudinal and transverse magnetoresistances due to current-induced magnon creation-annihilation processes
Creators: name: Noël, Paul
name: Schlitz, Richard
name: Karadža, Emir
name: Lambert, Charles-Henri
name: Nessi, Luca
name: Binda, Federico
name: Gambardella, Pietro
Publisher: name: ETH Zurich
Year: 2024

description: Charge-spin conversion phenomena such as the spin Hall effect allow for the excitation of magnons in a magnetic layer by passing an electric current in an adjacent nonmagnetic conductor. We demonstrate that this current-induced modification of the magnon density generates an additional nonlinear longitudinal and transverse magnetoresistance for every magnetoresistance that depends on the magnetization. Using harmonic measurements, we evidence that these magnon creation-annihilation magnetoresistances dominate the second harmonic longitudinal and transverse resistance of thin Y3Fe5O12/Pt bilayers. Our results apply to both insulating and metallic magnetic layers, elucidating the dependence of the magnetoresistance on applied current and magnetic field for a broad variety of systems excited by spin currents.
description: arXiv
Channel evolution in the lower reach of paleo Fen River: evidence from detrital apatite petrochronology and zircon geochronology
Creators: name: Wang, Zhongmei
name: He, Honglin
name: Shi, Feng
name: Zhuang, Qitian
Publisher: name: Geological Society of London
Year: 2024
Subjects: classificationCode: 3705
subject: Geology
subject: FOS: Earth and related environmental sciences

description: Supplementary Table 5.
Therapists' discursive constructions of shame : a story-completion task.
Creators: name: Drini, Eugenia
Publisher: name: University of Surrey
Year: 2020

description: This study aimed to explore the ways that shame is constructed by therapeutic practitioners. It utilised a novel method, called ‘story completion’ to analyse the stories completed by 45 therapists of various theoretical and professional backgrounds, using Foucauldian discourse analysis (FDA). The analysis highlighted some of the dominant ways that certain discourses about emotions and shame tend to be taken-for-granted within the therapeutic framework. In most stories shame was constructed around one’s private, ‘authentic’ self, which was 'hidden' behind shame related behaviours. It was argued that the discourse of shame as a problematic emotion is inextricably linked to the western values of autonomy and self-sufficiency, which are echoed in most forms of therapy. These concepts could be seen as detaching emotions from their context, and not paying sufficient attention to the wider socio-cultural framework. It was contended that clinicians need to be sceptical about taken-for-granted values of psychotherapy, including therapists’ ‘expertise’. They also need to be mindful of the ways that dominant psychological theories may conceal the power struggles in the therapy room and reflect on the ways they frame their clients’ emotions.
SPIHT-based Image Archiving Under Bit Budget Constraints
Creators: name: He, Yifeng
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Image Archving
SPIHT

description: Image archiving is important in various applications. In this work, we formulate the problem of compressing image archives as an optimization problem and present an efficient method for solving this problem. Our method is based on adapting SPIHT to image archiving where the total bit budget is distributed optimally across the images. We show experimentally that this method significantly outperforms its counter-part, namely, SPIHT with equal distribution of bit budget.
Reverse Engineering Behavioural Models by Filtering out Utilities from Execution Traces
Creators: name: Braun, Edna
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Reverse Engineering
Behavioural Models
Software Maintenance
Software Comprehension
Trace Compression
Trace Visualization
Feature Location

description: An important issue in software evolution is the time and effort needed to understand existing applications. Reverse engineering software to recover behavioural models is difficult and is complicated due to the lack of a standardized way of extracting and visualizing knowledge. In this thesis, we study a technique for automatically extracting static and dynamic data from software, filtering and analysing the data, and visualizing the behavioural model of a selected feature of a software application. We also investigate the usefulness of the generated diagrams as documentation for the software. We present a literature review of studies that have used static and dynamic data analysis for software comprehension. A set of criteria is created, and each approach, including this thesis’ technique, is compared using those criteria. We propose an approach to simplify lengthy traces by filtering out software components that are too low level to give a high-level picture of the selected feature. We use static information to identify and remove small and simple (or uncomplicated) software components from the trace. We define a utility method as any element of a program designed for the convenience of the designer and implementer and intended to be accessed from multiple places within a certain scope of the program. Utilityhood is defined as the extent to which a particular method can be considered a utility. Utilityhood is calculated using different combinations of selected dynamic and static variables. Methods with high utilityhood values are detected and removed iteratively. By eliminating utilities, we are left with a much smaller trace which is then visualized using the Use Case Map (UCM) notation. UCM is a scenario language used to specify and explain behaviour of complex systems. By doing so, we can identify the algorithm that generates a UCM closest to the mental model of the designers. Although when analysing our results we did not identify an algorithm that was best in all cases, there is a trend in that three of the best four algorithms (out of a total of eight algorithms investigated) used method complexity and method lines of code in their parameters. We also validated the algorithm results by doing a comparison with a list of methods given to us by the creators of the software and doing precision and recall calculations. Seven out of the eight participants agreed or strongly agreed that using UCM diagrams to visualize reduced traces is valid approach, with none who disagreed.
Channel evolution in the lower reach of paleo Fen River: evidence from detrital apatite petrochronology and zircon geochronology
Creators: name: Wang, Zhongmei
name: He, Honglin
name: Shi, Feng
name: Zhuang, Qitian
Publisher: name: Geological Society of London
Year: 2024
Subjects: classificationCode: 3705
subject: Geology
subject: FOS: Earth and related environmental sciences

description: Supplementary Table 1.
Generalized scheduling development environment
Creators: name: Fabens, William
name: Sterling, Leon
Publisher: name: Swinburne
Year: 2024

description: A generalized scheduling development environment allows a person who composes schedules to specify both an application and a methodology, in developing a scheduling program. The authors have designed such a system and have built a proof-of-concept prototype. The prototype has been tested on two fairly different application examples. It demonstrates the expressive capability of logic programming in representing the diversity of the two examples, and it exemplifies a method of achieving generality in the domain of scheduling.
Iconic turn. Alcune chiavi di svolta
Creators: name: Alloa, Emanuele
Publisher: name: Lebenswelt. Aesthetics and philosophy of experience.
Year: 2012

description: Two decades after the “iconic turn” has been proclaimed, it still remains uncertain whether that expression catches a paradigm shift which has actually taken place or whether it only yet calls forth for it to happen. The essay takes a look at the different ways in which the expression might be understood, referring either to a kind of visual thinking, a disciplinary self-reflection or a epistemic meta-discourse. The success of the expression goes hand in hand, so it seems, with the uncertainty of its status, as still today, it is by no means evident to question the evidence of the image. Against the verdict of the philologist Ernst Robert Curtius, still echoing today, who claimed that, in contrast with the science of text, “the science of images is easy”, the essay advocates for three ‘turns of the screw’ in order to make image theory ‘more difficult’: the turn from an iconology to a    symptomatology, from extensive to intensive and from indicative to conjunctive.
description: Lebenswelt. Aesthetics and philosophy of experience., N° 2 (2012)
Insights on mental health when living with rheumatoid arthritis: a descriptive qualitative study of threads on the Reddit website
Creators: name: Park, Jamie Y.
name: Howren, Alyssa
name: Davidson, Eileen
name: De Vera, Mary
Publisher: name: BioMed Central
Year: 2020

description: Background: Reddit is a highly visited social news and discussion website where individuals anonymously ask questions, post opinions and share experiences, which provide a valuable pool of publicly available data. Our objective was to systematically search and analyze threads on the social news website, Reddit, to understand experiences of individuals with rheumatoid arthritis (RA) regarding their mental health. Methods: We conducted a patient-oriented descriptive qualitative study. We identified threads from two subreddits, “r/Thritis” and “r/Rheumatoid”, using keywords such as “mood”, “mental health”, “stressed”, “depressed”, “anxious” over a 1-year period between June 2018 and June 2019. For included threads, we extracted the title, original post, and corresponding comments and responses. We applied thematic analysis using an inductive approach. Results: Of 81 threads identified, we included 27. We identified four themes: 1) Navigating the management of RA explores how the physical impacts of the disease, lack of health resources/support and the complexity of medications affect mental health; 2) Experiencing impact on relationships and social isolation includes experiencing misconceptions of RA, feeling misunderstood and feeling guilt; 3) Experiencing loss, touches on the helplessness brought by challenges with performing self-defining activities such as self-care, work, and childbearing/parenting; and finally, 4) Experiencing emotional struggles captures how tension between fighting through and despair has led some to suicide ideation and thoughts of death. Conclusions: Online forums and communities such as Reddit have created opportunities for individuals with RA to share experiences on mental health matters, which they may not necessarily be able to share with others.
Supplementary document for Optical memory effect in square multimode fibers - 5428072.pdf
Creators: name: Caravaca, Antonio
name: Carron, Adrien
name: Mezil, Sylvain
name: Wang, Irène
name: Bossy, Emmanuel
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Classical and Physical Optics

description: Supplemental document
Boehm, Mitchell e una storia ancora da scrivere
Creators: name: Vargiu, Luca
Publisher: name: Lebenswelt. Aesthetics and philosophy of experience.
Year: 2012

description: Following the correspondence between Boehm and Mitchell, the paper discusses some focal points related to the so-called iconic, or pictorial turn: the difficulty in writing a history of the Bildwissenschaft, the role of the medieval studies, affinities and differences between the European and the American approach to image (and between Boehm’s and Mitchell’s approach), the Italian and French reception, the meaning to attribute to the word ‘turn’, and the relationship among the iconic or pictorial turn, the visual studies and more traditional disciplines such as aesthetics and art history.
description: Lebenswelt. Aesthetics and philosophy of experience., N° 2 (2012)
The Essential Role of the Crtc2-CREB Pathway in β Cell Function and Survival
Creators: name: Eberhard, Chandra
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Diabetes
Insulin
Creb
Crtc2
Calcineurin
Phosphorylation
beta cell

description: Immunosuppressants that target the serine/threonine phosphatase calcineurin are commonly administered following organ transplantation. Their chronic use is associated with reduced insulin secretion and new onset diabetes in a subset of patients, suggestive of pancreatic β cell dysfunction. Calcineurin plays a critical role in the activation of CREB, a key transcription factor required for β cell function and survival. CREB activity in the islet is activated by glucose and cAMP, in large part due to activation of Crtc2, a critical coactivator for CREB. Previous studies have demonstrated that Crtc2 activation is dependent on dephosphorylation regulated by calcineurin. In this study, we sought to evaluate the impact of calcineurin-inhibiting immunosuppressants on Crtc2-CREB activation in the primary β cell. In addition, we further characterized the role and regulation of Crtc2 in the β cell. We demonstrate that Crtc2 is required for glucose dependent up-regulation of CREB target genes. The phosphatase calcineurin and kinase regulation by LKB1 contribute to the phosphorylation status of Crtc2 in the β cell. CsA and FK506 block glucose-dependent dephosphorylation and nuclear translocation of Crtc2. Overexpression of a constitutively active mutant of Crtc2 that cannot be phosphorylated at Ser171 and Ser275 enables CREB activity under conditions of calcineurin inhibition. Furthermore, β cells lacking Crtc2 display impaired glucose-stimulated insulin secretion and cell survival. Together, these results demonstrate that phosphorylation of Crtc2 plays a critical role in regulating CREB activity and contributes to β cell dysfunction and death caused by chronic immunosuppression.
Sound event detection with weakly labelled data
Creators: name: Kong, Qiuqiang
Publisher: name: University of Surrey
Year: 2020

description: Sound event detection (SED) is a problem to detect the onset and offset times of sound events in an audio recording. SED has many applications in both academia and industry, such as multimedia information retrieval and monitoring domestic and public security. However, compared to speech signal processing that have been researched for many years, the classification and detection of general sounds has not been researched much until recent years. One limitation of the study on audio classification and sound event detection is that there have been limited datasets public available until the release of the release of the detection and classification of acoustic scenes and events (DCASE) dataset. The DCASE dataset consists of data for acoustic scene classification (ASC), audio tagging (AT) and sound event detection. ASC and AT are tasks to design systems to predict pre-defined labels in an audio clip. SED is a task to design systems to predict both the presence or absence of sound events in an audio clip as well as the onset and offset times of the sound events. One difficulty of the audio classification and SED task is that many datasets such as the DCASE dataset are weakly labelled. That is, only the presence or absence of sound events in an audio clip is known, without knowing the onset and offset annotations of the sound events. This thesis focused on solving the audio tagging and sound event detection problem using only weakly labelled data. This thesis proposed attention neural networks to solve the general weakly labelled AT and SED problem. The attention neural networks can automatically learn to attend to important segments and ignore silence and irrelevant segments in an audio clip. We developed a set of weak learning methods for AT and SED using attention neu- Abstract 3 ral networks. The proposed methods have achieved a state-of-the-art performance in audio tagging and sound event detection.
As Canadian as Possible: The Canadian Broadcasting Corporation, 1936-1939
Creators: name: Graham, Sean
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Canadian Broadcasting Corporation

description: Since its inception in November 1936, the Canadian Broadcasting Corporation has been a constant presence in Canada’s cultural landscape. In its earliest days, however, that longevity was far from guaranteed as there were plenty of issues threatening the survival of the national broadcaster. Following the demise of the Canadian Radio Broadcasting Commission, Canada’s first public broadcaster, the CBC was given the responsibility of establishing and expanding Canada’s national radio network while also serving as the regulatory body for privately owned stations. In order to fulfill this mandate, the CBC’s first three years centred on building stations, expanding its programs, controlling its finances, and maintaining positive and productive relationships. This dissertation examines the CBC’s first three years and the corporation’s efforts to survive its tumultuous infancy while also establishing itself as an essential Canadian cultural institution. The CBC’s efforts during the Second World War have received plenty of scholarly attention, but a study of its formative period between 1936 and 1939 is essential to understanding the broadcaster’s role in Canadian life. The corporation’s handling of linguistic tensions, regional divides, and urban and rural separation were all critical to its early growth and played a significant role in providing the CBC the time to build its national network. Central to that plan was the corporation’s tacit policy of continental integration. Prior to the wide distribution of television in the 1950s, radio, which served as the primary source of mass entertainment in the home, was dominated in Canada by American stations and programs. Understanding the power and popularity of American radio, the CBC aired American programs and developed productive relationships with American radio networks in order to promote its place as Canada’s national broadcaster. Through these relationships, the CBC was able to reduce network interference while also using American content to reorient listeners towards Canadian stations. The CBC also sent Canadian programs to American networks, which it then used as proof that it was producing world-class programming. This study argues that the internal structure established between 1936 and 1939 allowed the corporation to position itself as a vibrant national broadcaster, an essential component of which was its successful integration into North America’s wider broadcasting system.