title: Ð¡ÑÑÑÐºÑÑÑÐ½Ð¾-ÑÑÐ½ÐºÑÐ¸Ð¾Ð½Ð°Ð»ÑÐ½ÑÐµ Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸ Ð¼ÐµÐ¼Ð±ÑÐ°Ð½Ñ ÑÑÐ¾Ð¼Ð±Ð¾ÑÐ¸ÑÐ¾Ð² Ð¿ÑÐ¸ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ð¸ Ð·Ð»Ð¾ÐºÐ°ÑÐµÑÑÐ²ÐµÐ½Ð½ÑÑ Ð½Ð¾Ð²Ð¾Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ð¹ ÑÐ°Ð·Ð»Ð¸ÑÐ½Ð¾Ð³Ð¾ Ð³Ð¸ÑÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐ¸Ð¿Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Structural and functional features of the platelet membrane in the development of malignant neoplasms of various histological types
Creators: name: ÐÑÑÐºÐ¸Ð½Ð°, ÐÐºÐ°ÑÐµÑÐ¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2021
Subjects: Ð Ð°Ð´Ð¸Ð¾Ð»Ð¾Ð³Ð¸Ñ
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description: The aim of the final qualification work: study of the structural features and functional activity of platelets in laboratory rodents during the development of tumors of various histological types and during antitumor therapy. 1. To reproduce malignant neoplasms of various histological types in laboratory animals - colon adenocarcinoma and primary brain tumor. 2. To investigate the dynamics of morphological and functional characteristics of platelets in the development of malignant neoplasms of various histological types. 3. To assess the structural and functional changes in platelets in animals with malignant neoplasms during experimental chemotherapy. The work was carried out on the basis of the the Center of Preclinical and Clinical Research of Molecular and Radiation Biophysics Division of the NRC âKurchatov Institute" â PNPI and on the basis of Department of Pathological Physiology with the course of immunopathology of the Federal State Budgetary Educational Institution of Higher Education, St. Petersburg State Medical University of the Ministry of Health of Russia. Two widely used models of malignant neoplasms were reproduced: adenocarcinoma of the colon (AKATOL) and C6 glioma that were transplanted by the ectopic (AKATOL) and organotopic (C6 glioma) methods. The success and rates of neoplasm development in both models were sufficient for the subsequent analysis of the treatment effectiveness and determination of the stage of tumor development. To study the dynamics of morphological and functional characteristics of platelets during the development of malignant neoplasms, samples of platelets from the blood of intact animals and animals with transplanted tumors were studied. Changes in the number of platelets and their mean volume were measured using a hematology analyzer, the adhesive activity of platelets was measured by their adhesion to glass, and the number of P-selectin positive platelets was estimated using a flow cytometer. The development of neoplasms in the models of the tumor process used was characterized by a high activation of the platelet component of the formed elements of the blood of animals. There was an increase in the total number of platelets in the blood, the average volume of these cells and their adhesive properties, which were also accompanied by a significant increase in the expression of P-selectin on the platelet membrane without significant differences in the direction and intensity of disturbances in the work of platelets in animals, which may indicate the universal nature of disorders that do not depend on the histology of neoplasms and their localization. The drugs Cyclophosphan and Cycloferon used in the study demonstrated, in general, comparable efficacy against the models of malignant neoplasms used, increasing the duration of the latent period of tumor development at the transplantation site and the overall life expectancy of animals. Both drugs used, within their therapeutic window, caused additional platelet activation. At the same time, the mechanisms of activation of these shaped elements were significantly different.