cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Économie Circulaire et conception d’Outil d’Optimisation de la stratégie de gestion des Déchets de Déconstruction (ECO2D2) – Présentation du projet et du contexte d’étude
Creators: name: Eva, QUEHEILLE
name: SAIYOURI, Nadia
name: TAILLANDIER, Franck
name: GUERLOU, Pierre
Publisher: name: Academic Journal of Civil Engineering
Year: 2020

description: Ce papier présente le contexte d’étude du projet ECO2D2 (Économie Circulaire et conception d’Outil d’Optimisation de la stratégie de gestion des Déchets de Déconstruction). Les réglementations environnementales européenne et française se sont associées pour proposer l’objectif d’une valorisation minimale à 70% pour les déchets issus des activités du bâtiment et des travaux publics en 2020. Les plus gros efforts seront à mener dans le secteur du bâtiment, où se côtoie une grande diversité de déchets. Les premières constatations chez le partenaire professionnel et les lectures bibliographiques ont montré que les pratiques peinent à inclure l’environnement : difficulté à estimer les déchets du futur chantier, tri non systématique, manque de traçabilité… De nouvelles stratégies sont prévues sur des chantiers-tests pour améliorer la gestion des déchets et se concrétiseront dans la conception d’un outil d’aide à la décision pour les entreprises de déconstruction
description: Academic Journal of Civil Engineering, Vol 35 No 1 (2017): Special Issue - RUGC 2017 Nantes
title: 02_1860
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Additional file 3: Figure S1. of Iatrogenic Creutzfeldt-Jakob disease with Amyloid-β pathology: an international study
Creators: name: Cali, Ignazio
name: Cohen, Mark
name: Haїk, Stéphane
name: Parchi, Piero
name: Giaccone, Giorgio
name: Collins, Steven
name: Kofskey, Diane
name: Wang, Han
name: McLean, Catriona
name: Brandel, Jean-Philippe
name: Privat, Nicolas
name: Sazdovitch, Véronique
name: Duyckaerts, Charles
name: Kitamoto, Tetsuyuki
name: Belay, Ermias
name: Maddox, Ryan
name: Tagliavini, Fabrizio
name: Pocchiari, Maurizio
name: Leschek, Ellen
name: Appleby, Brian
name: Safar, Jiri
name: Schonberger, Lawrence
name: Gambetti, Pierluigi
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Cell Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Cancer
subject: Science Policy

description: Kaplan–Meier estimates of iCJD and sCJD controls. A: survival graphs representing whole iCJD cohort and its GH- and DM-iCJD subsets as well as sCJD cases. B: survival graphs of 21 iCJD and all sCJD divided into two groups according to age: 54 years or younger (≤54y), and older than 54 years (> 54y). Median survivals are indicated on the X-axis in A and B (arrowheads). Significant differences in median survivals, determined by the log rank (Mantel-Cox), were found between GH-iCJD and sCJD (P=0.0017) (A) or DM-iCJD ≤ 54y and sCJD ≤ 54y (P=0.0027) (B). (PDF 2348 kb)
A genome-wide gene overexpression screen for mitophagy mutants in the yeast Saccharomyces cerevisiae
Creators: name: Lucarelli, Giuseppe Andrea
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Autophagy is a fundamental pathway conserved amongst all eukaryotic cells that is necessary for the degradation of intracellular structures, including organelles, to maintain cellular homeostasis. Being a fundamental process, autophagy is linked with many other intracellular pathways, and its dysfunction is associated with many human diseases. Mitochondria can be degraded by autophagy after delivery to the vacuole (in yeast) or lysosome (in mammalian cells) in a selective process termed mitophagy. Significant contribution to the understanding of mitophagy has come from research on the model organism Saccharomyces cerevisiae. Two non-essential gene deletion screens have identified two genes, ATG32 and ATG33, encoding components of the mitophagy pathway both localised at the outer mitochondrial membrane (OMM). Atg32p acts as the essential receptor activated by phosphorylation allowing interaction with core autophagy proteins resulting in mitophagy. However, our knowledge of mitophagy and its regulation in yeast is incomplete requiring further investigation. To this end, I developed a high-throughput imaging assay based on the use of a mitochondrially targeted fluorescent protein biosensor called mt-Rosella. The assay is performed using a 96-well format in a semi-automated fashion and allows the screening of different strain libraries under a range of different conditions. Using this assay I investigated the effects of gene overexpression on mitophagy using a library comprised of 1588 high-copy number plasmids that cover more than 95% of the yeast genome including essential genes (previously excluded from the deletion library). Each plasmid contains on average 5 contiguous genes each under the expression control of their endogenous promoter. The screen revealed that increased expression of a number of genes can affect mitophagy. Among such genes, I found that OM14 encoding the OMM protein Om14p confers a strong decrease in mitophagy when overexpressed in cells. Subsequently a similar phenotype was observed in cells in which the OM14 gene was deleted. Om14p is required for co-translational import of proteins into mitochondria and also forms a complex with the OMM proteins Por1p and Om45p. Preliminary results indicate that lack of Om14p leads to a significant reduction in amounts of Atg32p in cells suggesting the involvement of Om14p in the co-translational import of Atg32p in mitochondria. Another line of evidence indicates that the absence of Om14p causes a perturbation in the ultrastructure of mitochondria suggesting a role for Om14p in mitochondrial architecture, the alteration of which could indirectly affect proteins essential for mitophagy, including Atg32p. Further investigation is required to fully understand the role of Om14p in mitophagy.
Learning State Conditioned Linear Mappings for Low-Dimensional Control of Robotic Manipulators
Creators: name: Przystupa, Michael
name: Johnstonbaugh, Kerrick
name: Zhang, Zichen
name: Petrich, Laura
name: Dehghan, Masood
name: Haghverd, Faezeh
name: Jagersand, Martin
Publisher: name: arXiv
Year: 2024
Subjects: subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: Identifying an appropriate task space that simplifies control solutions is important for solving robotic manipulation problems. One approach to this problem is learning an appropriate low-dimensional action space. Linear and nonlinear action mapping methods have trade-offs between simplicity on the one hand and the ability to express motor commands outside of a single low-dimensional subspace on the other. We propose that learning local linear action representations that adapt based on the current configuration of the robot achieves both of these benefits. Our state-conditioned linear maps ensure that for any given state, the high-dimensional robotic actuations are linear in the low-dimensional action. As the robot state evolves, so do the action mappings, ensuring the ability to represent motions that are immediately necessary. These local linear representations guarantee desirable theoretical properties by design, and we validate these findings empirically through two user studies. Results suggest state-conditioned linear maps outperform conditional autoencoder and PCA baselines on a pick-and-place task and perform comparably to mode switching in a more complex pouring task.
description: 7 Pages, 8 Figures, Presented at the 2023 IEEE International Conference on Robotics and Automation (ICRA)
Stratégies d’optimisation des résistances mécaniques d’un matériau à base de terre crue
Creators: name: RANGEARD, Damien
name: PERROT, Arnaud
Publisher: name: Academic Journal of Civil Engineering
Year: 2020

description: La terre crue est traditionnellement renforcé avec des matériaux biosourcés comme la paille ou des biopolymères. Le but de cette étude est de trouver des renforts naturels capables d’améliorer réellement la résistance et la ductilité de terres crues. Nous essayons aussi de démontrer les mécanismes de renforcement mises en jeu. Dans un premier temps, nous montrons l’importance de la densité sèche du matériau sur la résistance mécanique à la compression de blocs de terre crue dont la fraction fine est composée de kaolinite. Nous montrons notamment que la résistance ne dépend pas du mode de mise en oeuvre à densité sèche égale. Dans un second temps, différents niveaux d’ajouts d’alginate, de fibres de lin et de tissés de lin sont testés pour renforcer la terre crue. Nous montrons que ces ajouts sont capables d’améliorer la résistance à la compression et la ductilité des matériaux à base de kaolinite contrairement à ce que l’on trouve sur la terre contenant de la smectite.
description: Academic Journal of Civil Engineering, Vol 35 No 1 (2017): Special Issue - RUGC 2017 Nantes
Additional file 4: Figure S2. of Iatrogenic Creutzfeldt-Jakob disease with Amyloid-β pathology: an international study
Creators: name: Cali, Ignazio
name: Cohen, Mark
name: Haїk, Stéphane
name: Parchi, Piero
name: Giaccone, Giorgio
name: Collins, Steven
name: Kofskey, Diane
name: Wang, Han
name: McLean, Catriona
name: Brandel, Jean-Philippe
name: Privat, Nicolas
name: Sazdovitch, Véronique
name: Duyckaerts, Charles
name: Kitamoto, Tetsuyuki
name: Belay, Ermias
name: Maddox, Ryan
name: Tagliavini, Fabrizio
name: Pocchiari, Maurizio
name: Leschek, Ellen
name: Appleby, Brian
name: Safar, Jiri
name: Schonberger, Lawrence
name: Gambetti, Pierluigi
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Developmental Biology

description: Histopathology of an atypical US iCJD (case 5, Table 1). A-C: HE staining. D and E: PrP immunohistochemistry. A: spongiform degeneration (SD) with large and confluent vacuoles typical of the sCJDMM2 subtype, but limited to layer II of the frontal cortex, and severe neuronal loss and gliosis affecting all layers. B: high magnification of the area highlighted in A showing SD with large vacuoles. C: severe loss of granule cells and gliosis of the cerebellum; Grl. L: granular layer; Mol. L: molecular layer. D and E: diffuse or “synaptic” PrP immunostaining in the frontal cortex (D), and molecular and granular layers of the cerebellum (E); A-C: HE staining. D and E: PrP immunohistochemistry with Ab 3F4. (PDF 30981 kb)
OLIY TA'LIMDA KOMPYUTER GRAFIKASI SAVODXONLIGINING O'RNI VA VAZIFALARI
Creators: name: Qobiljonova, Jasmina
Publisher: name: Zenodo
Year: 2024

description: Bugungi zamonaviy  texnik ishlab chiqarish ko‘p vaqt va og‘ir qo‘l mehnatini talab etuvchi loyihalash va konstruktsiyalash ishlarini Avtomatlashtirilgan Loyixalash Tizimi (ALT) zimmasiga yuklay oladigan bo‘lajak o‘qituvchilarni talab etmoqda. Shu sababli bugungi kunda biz talabalarga kompyuter grafikasidagi bilim  va malakalarni chuqur egallash asosiy vazifa bo’lib qolmoqda.
Chaotic advection in a three-dimensional volume-preserving potential flow
Creators: name: Smith, Lachlan Dean
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: While mixing and particle transport in 2D incompressible flows are well-understood, much less is known about 3D incompressible flows. This is because the addition of a third dimension adds to the topological complexity, and more importantly, the link between 2D incompressible flows and Hamiltonian systems that proved so fruitful breaks down for 3D flows. Therefore, there is a need for fundamental studies on 3D fluid transport and mixing, with applications in groundwater flows, micro-fluidics, industrial mixers and biological flows. Here fluid transport and mixing is studied using a model fluid flow, the 3D Reoriented Potential Mixing (3DRPM) flow, as a case study to reveal novel transport mechanisms and associated coherent structures that are generic to 3D volume-preserving flows. The 3DRPM flow consists of a periodically reoriented dipole flow, and is a 3D analogue of the 2D RPM flow that has been studied in the past. In the 3DRPM flow it is found that there are a number of competing transport mechanisms, that together drive a transition from 1D to 3D particle transport. Periodic points and lines play an important role for all volume-preserving flows, revealing regions of chaos and impenetrable barriers to transport. Here it is shown that degenerate/parabolic periodic points are particularly important, as they represent bifurcations in flow stability. Conversely, discontinuous deformations are an unexpected consequence of dipole reorientation, akin to slip deformations seen in shear-banding materials, and occur even though the steady dipole flow is smooth. This has a significant impact on the transport behaviour of particles, and can either enhance or impede the rate of mixing. The combination of smooth and discontinuous deformations is generic to a wide range of systems, including flows with extraction and reinjection of fluid, granular flows, and deformations of shear-banding materials. Here it is shown that discontinuous deformations can destroy impenetrable barriers to transport, allowing greater freedom for particle transport. In 3D systems they can create a novel mechanism for fully 3D transport that is similar in effect to Resonance Induced Dispersion.
Méta-modélisation basée sur le chaos polynomial d’un modèle multi-physique de chloration du béton pour estimer les effets du changement climatique
Creators: name: NGUYEN, Phu Tho
name: BASTIDAS-ARTEAGA, Emilio
name: EL SOUEIDY, Charbel-Pierre
name: AMIRI, Ouali
Publisher: name: Academic Journal of Civil Engineering
Year: 2020

description: La corrosion induite par les ions chlorure est l’une des principales causes de la dégradation précoce des constructions en béton armé. L’estimation du temps d’initiation de la corrosion dépend de la modélisation de la chloration qui demeure une tâche complexe. Notre travail consiste donc en une méta-modélisation du mécanisme de chloration pour prendre en compte des incertitudes des paramètres du matériau et climatiques, en vue d’une évaluation du risque de corrosion. Le méta-modèle se repose sur une approximation par polynômes de chaos qui se base sur la méthode de régression. Afin d’étudier l’efficacité du méta-modèle, deux structures exposées à deux types caractéristiques d’exposition et de climat (zone de marnage à Brest et zone continentale à Strasbourg) sont considérées. Les premiers résultats obtenus montrent que le méta-modèle permet de gagner beaucoup de temps de calcul par rapport au calcul classique tout en gardant la précision du modèle déterministe. L’analyse de sensibilité par indices de Sobol permet de relever l’importance de chaque paramètre pour le temps d’amorçage de la corrosion. De plus, différents scénarios climatiques sont également pris en compte afin d’évaluer l’effet du réchauffement climatique sur la probabilité d’initiation de la corrosion des structures en béton armé.
description: Academic Journal of Civil Engineering, Vol 35 No 1 (2017): Special Issue - RUGC 2017 Nantes
Cultural adjustment in the context of an aid-funded higher education sojourn: an exploratory case study that examines acculturation and re-acculturation challenges for Indonesian PhD Australian scholarship awardees
Creators: name: Medica, Karen Marie
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: In the context of rising global mobility, managers and policy makers need to understand the complexity of cultural adjustment issues experienced by educational and professional sojourners, taking into account the context-specific nature and purpose of sojourn and re-acculturation to the home country. The thesis examines the cultural adjustment challenges in the context of an Australian aid-funded PhD-level higher education program and relates these challenges to existing scholarly literature and conceptual models that seek to explain the nature of sojourner cultural adjustment, including inter-cultural relations and identity change. The study offers a new conceptual framework to understand issues of cultural adjustment, including reentry adjustment, which is under-researched in both the international student and expatriate management literature. The in-depth qualitative study investigates the lived experiences of 41 PhD Australian Development Scholarship awardees, including 27 returned Indonesian academics. The thesis contributes empirical and novel, context-specific findings to existing scholarly international management, international education and intercultural literature. The study extends existing conceptual frameworks to take into account the hybrid and specific nature of these sojourners as both international students and knowledge workers. The study builds on theoretical insights related to adjustment, including motivation, expectancy violations, culture-learning and inter-cultural identity. The findings provide insights that can assist foreign aid and higher education policy makers to enhance the development and educational effectiveness of international higher education programs.
Additional file 1: of Street-level workers’ inadequate knowledge and application of exemption policies in Burkina Faso jeopardize the achievement of universal health coverage: evidence from a cross-sectional survey
Creators: name: Ridde, Valéry
name: Leppert, Gerald
name: Hien, Hervé
name: Robyn, Paul
name: De Allegri, Manuela
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: International Standard Classification of Occupations in Burkina Faso. (DOCX 72 kb)
Unfolding X-ray Spectral Data: Conditions and Applications
Creators: name: Gunderson, Sean J.
name: Huenemoerder, David P.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present conditions for which X-ray spectra can be ``unfolded'' to present accurate representation of the true source spectra. The method we use to unfold the data is implemented in the \textit{Interactive Spectral Interpretation Software} \citep{Houck2000} and distinguishes itself as being model-independent. We find that this method of unfolding makes accurate representations of the true source spectra (1) The detector is high-resolution and (2) The spectrum is not steeply sloped. These criteria are not simple conditions that give concrete determinations; each detector and spectrum must be judged individually. We find that both grating and imaging detectors can be unfolded with minimal distortions as compared to both continuum and local spectral features; the latter CCD detectors being much more energy dependent. We also provide example use cases for unfolding in the context of current generation X-ray observatories and important caveats.
Impact of Human Development Index on Tribal Community in the Light of Educational Development Indicator
Creators: name: Gaurav Dhakad*
name: Meenu Jain
Publisher: name: Zenodo
Year: 2023
Subjects: Study of the impact of development on the tribal community of the Human Development Index in the field of education.

description: Abstract: Presented small research study "Efforts are being made to complete the small research study keeping in mind the study of the impact of development of human development index on the tribal community in the field of education.

Four important indicators have been determined by the Government of India to measure the level of some development to advance the tribal community, on the basis of which today every effort is being made to advance every person. These development parameters are as follows, which are 1. Per Capita Income 2. Physical Quality of Life Indicator 3. Human Development Index 4. Quality of Life Indicator.

Today, keeping this basis in mind, the level of the country, every person belonging to every person, community and religion has to work keeping in mind these four standards of development. Most of the people residing in the tribal community are those who do not work on these indexes at all, for this, today by the Government of India, many types of programs, seminars, economic basis, educational base and It is taking various steps to increase the per capita income, so that the people of the tribal community can develop.

Many types of schemes are being implemented by the Central and State Governments to advance the tribal community, so that today the people of the tribal community can achieve the index of development. Whether it is in the field of education, in the field of employment, or in the field of business, to progress day by day, this is the purpose of the government.
Portland cement replacement materials and their impact on the reduction of greenhouse gas emissions in the environment
Creators: name: jafari, ali
name: Taghizadeh, Saeed
name: moradian, Akbar
Publisher: name: figshare
Year: 2022
Subjects: subject: 90501 Civil Geotechnical Engineering
subject: FOS: Civil engineering

description: Portland cement has been used as a building mortar for many years And to make this buildingmortar, which is one of the two main compounds of lime and clay, requires a lot of energyconsumption. To produce cement, pollution and NOx, CO2, SO2 And industrial waste productionincreases. Increasing use of concrete in the world has increased the production of cement Thisnumber is close to 4.2 trillion tons of cement annuall, Which causes the increasing production ofcarbon dioxide Carbon dioxide is a harmful greenhouse gas, Which contributes to globalwarming and melting polar ice and other contaminants from the ground and tear the ozone layer.It is now very important to use cements or their substitutes, especially pozzolans, forconstruction, Using pozzolan can reduce both energy loss and pollution caused by cementproduction And increase the quality of concrete obtained from the use of pozzolans.Pozzolans are silica and aluminum materials that combine with lime in the presence of water atordinary temperatures to form stable and tensile materials and have the property of cementation,Due to its compounds, it reduces the carbon dioxide in its production compared to ordinarycements and Portland cement And its quality increases compared to other cements and Portlandcement.Due to its similar properties to cement, this material is economical, increases the resistance toacid and alkali attack of aggregates and prevents extensive cracking of concrete, a property that is associated with the sealing of water retaining structures and also in connection with Chemicalattacks are of interest And has a higher ultimate strength than Portland cement as well as lessexpansion and is used for bulk building and road concreting. No cracking and failure when one ofpozzolan cement is used.Contributing to nature due to reduced consumption of fuel and raw materials of cement andreduction of air pollution and fossil fuels and lower cost of cement production compared to othercements and Portland cement
 (PDF) Portland cement replacement materials and their impact on the reduction of greenhouse gas emissions in the environment. Available from: https://www.researchgate.net/publication/358595739_Portland_cement_replacement_materials_and_their_impact_on_the_reduction_of_greenhouse_gas_emissions_in_the_environment [accessed Apr 11 2022].
Additional file 1: Table S1. of Continuity of care is an important and distinct aspect of childbirth experience: findings of a survey evaluating experienced continuity of care, experienced quality of care and womenâ s perception of labor
Creators: name: Perdok, Hilde
name: Verhoeven, Corine J.
name: van Dillen, Jeroen
name: Schuitmaker, Tjerk
name: Hoogendoorn, Karla
name: Colli, Jolanda
name: Schellevis, FranĂ§ois
name: de Jonge, Ank
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Cross-boundry continuity. The mean score for cross-boundary continuity of care for women referred during pregnancy and women referred during labor. Table S2 Item means and total scale score of the Pregnancy and Childbirth Questionnaire. Table S3 Item means and total subscale score of the Childbirth Perception Scale. (DOCX 18Â kb)
Structure-based studies in the development of anti-cancer enzyme inhibitors
Creators: name: Sundaram, Krithika
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Cancer is one of the most prevalent causes of death worldwide. This thesis focuses on structural studies of two targets from the Aldo-Keto Reductase family (Section A) and Phosphoinositide 3-kinase family (Section B). The Aldo-Keto reductases are associated in the pathogenesis of various diseases including cancer. Section A of the thesis includes structural and functional studies of two aldo-keto reductases: AKR1B14 and AKR1C3. AKR1B14 is a recently identified member of AKR1B subfamily and previous crystallographic studies have revealed the importance of a non-conserved residue in coenzyme binding. The mutagenesis studies of this residue have confirmed the decrease in binding affinity of the coenzyme. The findings presented in this section examine the different AKR1B14 mutants to structurally understand and explain the loss of affinity of coenzyme associated with mutation of this residue using crystallography and molecular modelling. AKR1C3 is believed to be involved in the catalytic metabolism of various steroids. AKR1C3 has gained immense attention as a potential therapeutic target due to its upregulation in breast and prostate cancer. Molecular modelling was used to investigate the structure-activity relationships governing AKR1C3 with various inhibitors and have enabled us in the identification of the structural determinants of inhibition. This information may aid in future development of selective inhibitors for both the targets. The second section of this thesis focuses on Phosphoinositide 3-kinases which are critical regulators of intracellular signalling pathways and are involved in various cellular processes. The class II PI3Ks have gained attention recently as they are believed to be upregulated in certain types of cancers and hence present as a potential therapeutic target. Section B of this thesis investigates the structural features of class II PI3KC2β to identify key residues that could be targeted for inhibitor selectivity. Computational and inhibition studies of various inhibitors of PI3KC2β has presented information that may be useful in future development of class II selective inhibitors.
Etude expérimentale de l’adhérence acier-béton à l’aide de la technique d’émission acoustique
Creators: name: MEZHOUD, D.
name: SALIBA, J.
name: SBARTAI, Z. M.
name: SAAD, M.
Publisher: name: Academic Journal of Civil Engineering
Year: 2020

description: La fissuration du béton est principalement influencée par la répartition des contraintes le long de l'interface entre l'acier et le béton. Ainsi, une évaluation quantitative de l'influence de la liaison acier-béton sur les propriétés de rupture est importante. Une investigation expérimentale sur l’adhérence acier-béton est présentée dans cette étude. Des essais d’arrachement ont été réalisés sur des éprouvettes prismatiques avec des barres d’acier de diamètres différents avec, en parallèle, un suivi continu à l’aide de la technique d’émission acoustique (EA). Deux modes de ruptures ont été observés selon le diamètre des barres : rupture par traction du béton et une rupture par glissement de l’acier avec un endommagement localisé à l’interface acier-béton. Les résultats montrent une bonne corrélation entre la contrainte d’adhérence et l’activité acoustique. La localisation des évènements acoustiques reproduit bien la position réelle des fissures. Les paramètres des signaux d’EA (durée, amplitude, fréquence, etc.) montrent une relation directe avec les modes de rupture et permettent de distinguer les différentes phases caractérisant l’interaction entre le béton et l’acier.
description: Academic Journal of Civil Engineering, Vol 35 No 1 (2017): Special Issue - RUGC 2017 Nantes
Additional file 1: of Application of extracorporeal membrane oxygenation in patients with severe acute respiratory distress syndrome induced by avian influenza A (H7N9) viral pneumonia: national data from the Chinese multicentre collaboration
Creators: name: Huang, Linna
name: Zhang, Wei
name: Yang, Yi
name: Wu, Wenjuan
name: Lu, Weihua
name: Xue, Han
name: Zhao, Hongsheng
name: Wu, Yunfu
name: Shang, Jia
name: Cai, Lihua
name: Liu, Long
name: Liu, Donglin
name: Wang, Yeming
name: Cao, Bin
name: Zhan, Qingyuan
name: Wang, Chen
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Blood flow during ECMO, changes in IPPV parameters and physiological indicators pre-ECMO and during ECMO. (DOCX 107Â kb)
Modèle bielles-tirants pour le support d’une poutre transversale acier noyée dans une poutre principale béton
Creators: name: MARIE, Frédéric
name: SOMJA, Hugues
Publisher: name: Academic Journal of Civil Engineering
Year: 2020

description: Traditionnellement, les bâtiments en charpentes métalliques et en béton armé sont issus de deux filières séparées. La construction mixte acier-béton reste avant tout conçue comme une charpente métallique, tirant un avantage limité de la présence des planchers en béton. Cependant, depuis quelques années, de nouvelles conceptions plus intégrées entre les deux matériaux voient le jour, essayant de les marier pour tirer avantage de leurs qualités respectives : la grande résistance de l’acier d’une part et le faible coût et la résistance à l’incendie du béton d’autre part, par exemple. Dans de telles conceptions, le béton peut aussi faire prévaloir une certaine facilité dans la réalisation des assemblages, grâce au monolithisme du béton coulé en place, là où les assemblages métalliques par boulonnage ou soudure demandent plus de technicité, et représentent une part non négligeable du coût de la structure. Il est donc assez naturel, dans une conception hybride, d’essayer de tirer bénéfice de cet avantage du béton. Cet article s’intéresse en particulier au dimensionnement de l’appui d’une poutre secondaire en acier traversant une poutre transversale en béton, par simple contact direct. Sur base d’une campagne expérimentale composée de cinq essais, un modèle bielles-tirants spécifique est développé. Il met en évidence l’effet du niveau de l’appui dans la hauteur de la poutre béton sur la typologie du modèle treillis.
description: Academic Journal of Civil Engineering, Vol 35 No 1 (2017): Special Issue - RUGC 2017 Nantes
title: OFROM: interview avec unine15z09d
Creators: name: Delafontaine, François
name: Mung
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.de7a41hu.v2#22f9f55d8fe75bed3010436ee1875537cee11592
The social externalities of Australian bus and coach operators: how governance affects community prosperity
Creators: name: Lowe, Christopher James
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Governments determine public transport provision based on service provision costs, without attention to valuing social contributions. This thesis explores the social contribution of various governance models in the Australian bus and coach industry by identifying and valuing the ways in which family and non-family bus operators interact with their communities. It asks whether the family-based transport business is the best model for public transport outcomes and whether this model is sustainable. It addresses the role of the industry representative body for operators in promoting and maintaining the best outcomes for community prosperity and encouraging the most effective corporate governance model.
Additional file 5: Figure S3. of Iatrogenic Creutzfeldt-Jakob disease with Amyloid-β pathology: an international study
Creators: name: Cali, Ignazio
name: Cohen, Mark
name: Haїk, Stéphane
name: Parchi, Piero
name: Giaccone, Giorgio
name: Collins, Steven
name: Kofskey, Diane
name: Wang, Han
name: McLean, Catriona
name: Brandel, Jean-Philippe
name: Privat, Nicolas
name: Sazdovitch, Véronique
name: Duyckaerts, Charles
name: Kitamoto, Tetsuyuki
name: Belay, Ermias
name: Maddox, Ryan
name: Tagliavini, Fabrizio
name: Pocchiari, Maurizio
name: Leschek, Ellen
name: Appleby, Brian
name: Safar, Jiri
name: Schonberger, Lawrence
name: Gambetti, Pierluigi
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Neuroscience
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Plant Biology

description: WB profile of resPrPSc from iCJD and sCJD controls using different WB systems for PrP detection. BHs from the frontal cortex (lanes 8-10) and cerebellum (lanes 1-7) treated with 100 U/ml PK (~2000 μg/ml) were probed with indicated Abs. PrP bands were resolved in 15% Tris-HCl, 8.7 cm-long (A-C and E) and 20 cm-long (D) gels, and visualized with near-infrared LI-COR system (A-D and E(i)) or chemiluminescence (E(ii) and E(iii)). A: profiles of resPrPSc from CJD obtained with an 8.7 cm-long gel are similar to those obtained with the 20 cm-long gels in Fig. 2. The unglycosylated resPrPSc ~21 kDa of type 1 (21), ~20 kDa of type i (i), ~19 kDa of type 2 (2) and ~18 kDa (18) are indicated. B: the ~20 kDa of type i (i) and ~21 kDa of type 1 (21) (lanes 3-8), but not the ~19 kDa band of type 2, immunoreact with Ab 12B2. Profile of resPrPSc from iCJDMMi (lane 5) is indistinguishable from that of CJDMVi+2 (lanes 3 and 4), but differs from those of iCJDMM1 and sCJDMM1 (lanes 6-8), as the ~21 kDa band predominates in these three conditions. C: only ~19 kDa (type 2), but not ~21 kDa (type 1) and ~20 kDa (type i) immunoreacted with Tohoku-2 (To-2). An ~18 kDa (18) band in CJDVV2 and CJDMVi+2, and an unidentified lower size fragment (large arrow) in all cases harboring type 2 were also detected. A non-specific band (indicated by three asterisks) was present in all tested samples. D: high resolution gel electrophoresis in 20-cm long gel revealing ~21 kDa (21) and the ~20 kDa band (i and arrowhead). E(i): enhanced image of dashed area in A showing the bands ~21 kDa (21), ~20 kDa (i and arrowhead), and ~19 kDa (19; lane 4). The detection of the resPrPSc ~20 kDa band in addition to the prominent ~21 kDa fragment in CJDMM1 is most likely due to our use of a high resolution electrophoretic systems. E(ii): profiles of unglycosylated resPrPSc from the same cases in E(i) visualized on film by chemiluminescence. Note that the three CJDMM1 (lanes 6-8) show only ~21 kDa bands. E(iii): the ~20 kDa and ~21 kDa bands visible in B (lanes 3-5) resolve as a single band of ~21 kDa (lanes 4 and 5) when visualized on film by chemiluminescence. (PDF 6122 kb)
Comparison of FRP rebars and steel rebars in concrete structures, especially bridges built on the seas
Creators: name: Jafari Marbini, Ali
name: Jazi, Akbar Moradian
name: Taghizadeh, Saeed
Publisher: name: figshare
Year: 2022
Subjects: subject: 90501 Civil Geotechnical Engineering
subject: FOS: Civil engineering

description: FRP rebar is a composite product that replaces steel rebars Andsignificantly prevents damage from rebar corrosion in corrosive and acidicenvironments. Use FRP rebar in places where there is no need for problemswith proximity to electric and magnetic fields, It is the best option forreinforcing concrete. This product due to its good resistance to the attack ofsulfates and chlorides, as well as its good resistance to corrosion and rust, ithas been widely used. Therefore, in order to reduce the cost of repairingoffshore structures that are exposed to the corrosive environment of the seaand due to the gradual loss of concrete cover, steel bars are destroyed.Polymer reinforced fibers (frp) have very good strength and behavioralproperties for use in reinforcement and seismic design of structures. Theweight of these fibers is 20% by weight of steel, while they have more than10 times the tensile strength of steel.
 (PDF) Comparison of FRP rebars and steel rebars in concrete structures, especially bridges built on the seas. Available from: https://www.researchgate.net/publication/358595720_Comparison_of_FRP_rebars_and_steel_rebars_in_concrete_structures_especially_bridges_built_on_the_seas [accessed Apr 11 2022].
Additional file 6: Figure S4. of Iatrogenic Creutzfeldt-Jakob disease with Amyloid-β pathology: an international study
Creators: name: Cali, Ignazio
name: Cohen, Mark
name: Haїk, Stéphane
name: Parchi, Piero
name: Giaccone, Giorgio
name: Collins, Steven
name: Kofskey, Diane
name: Wang, Han
name: McLean, Catriona
name: Brandel, Jean-Philippe
name: Privat, Nicolas
name: Sazdovitch, Véronique
name: Duyckaerts, Charles
name: Kitamoto, Tetsuyuki
name: Belay, Ermias
name: Maddox, Ryan
name: Tagliavini, Fabrizio
name: Pocchiari, Maurizio
name: Leschek, Ellen
name: Appleby, Brian
name: Safar, Jiri
name: Schonberger, Lawrence
name: Gambetti, Pierluigi
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology

description: Quantitative estimates of Thioflavin S-positive Aβ CP affecting the cerebral cortex in subjects with iCJD and sporadic AD (sAD). A: the density of Aβ CP, expressed as the percentage of cerebral cortex area occupied, was 5 times greater in subjects with sAD than in iCJD. B: size of Aβ CP (N=500), expressed as diameter, was greater in patients with sAD than in those with iCJD. C and D: representative microscopic fields showing fewer and smaller CP (arrows) in iCJD (C) than sAD (D) where cluster of very large CP (dashed square) could be detected. Bar graphs are expressed as mean ± standard error of the mean (SEM) in A or as mean ± standard deviation in B. Student's t-test (two-tailed). (PDF 3338 kb)
Mesolia Ragonot 1889
Creators: name: Landry, Bernard
name: Léger, Théo
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Pyralidae
Mesolia

description: Mesolia Ragonot, in Joannis & Ragonot, 1889
Mesolia currently includes 20 species distributed in all biogeographical regions of the globe (Nuss et al., 2024). In the Neotropical region species have been described only from the northern fringe, i.e., Dominican Republic (one species), Jamaica (one species), and Mexico (one species from Guerrero and one from Presidio, state unknown). The placement of the new Galápagos species in Mesolia is based on the most recent diagnosis of the genus (Bassi, 2013). However, in the species described here as new, the female has a simple corpus bursae (Fig. 51), as opposed to a bilobed corpus bursae in other species. Mesolia was recently (Léger et al., 2019) returned to tribe Ancylolomiini, which includes the Prionypterygini (syn.) of Landry (1995).
description: Published as part of Landry, Bernard & Léger, Théo, 2024, Taxonomic revision of the Crambinae (Lepidoptera, Pyralidae sensu lato) of the Galápagos Islands, Ecuador, pp. 357-387 in Revue suisse de Zoologie 131 (2) on page 358, DOI: 10.35929/RSZ.0129, http://zenodo.org/record/15085298
Additional file 1: of A modified TNM staging system for non-metastatic colorectal cancer based on nomogram analysis of SEER database
Creators: name: Kong, Xiangxing
name: Li, Jun
name: Cai, Yibo
name: Tian, Yu
name: Chi, Shengqiang
name: Tong, Danyang
name: Hu, Yeting
name: Yang, Qi
name: Li, Jingsong
name: Poston, Graeme
name: Yuan, Ying
name: Ding, Kefeng
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer

description: Table S1. The Demographic Information of the Patients from SEER Database Enrolled in This Study [online only]. Table S2. The Demographic Information of the Patients from SAHZU Database Enrolled in This Study [online only]. Table S3. The Ranking of Average Nomo-score [online only]. Table S4. Comparison of the Predictive Performance of 2 Staging Systems for Overall Survival of SAHZU dataset [online only]. (DOCX 78Â kb)
title: OFROM: interview avec unine15z08m
Creators: name: Delafontaine, François
name: Mung
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.a0ab1kbk.v2#b685575ca0153090a52ff1732c9f5e1740fa51ef
title: 02_1413
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Risk-based techniques in construction management
Creators: name: Jafari Marbini, Ali
name: Jazi, Akbar Moradian
name: Taghizadeh, Saeed
Publisher: name: figshare
Year: 2022
Subjects: subject: 90501 Civil Geotechnical Engineering
subject: FOS: Civil engineering

description: Risk management is one of the relatively young branches of project management that does notyet have a clear mechanism in construction projects. Studies show that the implementation ofrisk management techniques in construction projects is very limited. While there is a closerelationship between the implementation of risk management and indicators of project success,including cost, quality, safety and time. Especially in construction projects that are known asrisky projects with many uncertainties. Construction projects are prone to a variety of risksdue to the complex interactions between the contractor, the employer, the suppliers, theconsulting engineers, the subcontractors and other project stakeholders. Even with theimplementation of risk management in many large projects, we still see an estimated budgetinadequacy or a significant increase in project duration.
 (PDF) Risk-based techniques in construction management. Available from: https://www.researchgate.net/publication/358595575_Risk-based_techniques_in_construction_management [accessed Apr 11 2022].