cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
14. ANCA-IIF technique improvement and its impact on the positivity rate of ANCA tests
Creators: name: Zarur1, Eduarda
name: Silvia Helena Rodrigues Dos Santos1, MD, PhD
name: Orlando  Ambrogini Junior2, MD, PhD
name: Maria Lucia  Cardoso Gomes Ferraz2, MD, PhD
name: Gianna Mastroiani Kirsztajn3, MD, PhD
name: Luiz Eduardo Coelho Andrade1, MD, PhD
name: De Souza1, Alexandre Wagner Silva
Publisher: name: Zenodo
Year: 2022
Subjects: Vasculitis
ANCA
Abstracts
Giant Cell Arthritis
MPA
GPA
EGPA
Takayasu
IgA vasculitis

description: Background: The detection of antineutrophil cytoplasmic antibodies (ANCA) by indirect immunofluorescence (IIF) with ethanol-fixed neutrophils is subject to substantial differences across laboratories. A low positivity rate of the IIF-ANCA test compared to the literature was observed at a reference laboratory and the test’s protocol needed to be revised. This study aims to assess the impact of improvements in the IIF-ANCA technique on the positivity rate of ANCA tests. Methods: A cross-sectional study with serum samples from patients with ANCA-associated vasculitis (AAV), autoimmune hepatitis (AIH) and ulcerative colitis (UC) was performed. A paired analysis was performed for IIF-ANCA results using the traditional method and a modified protocol after a series of specific adjustments in the technique based on the protocol of IIF-ANCA test performed at a national-wide private laboratory in Brazil (Fleury Laboratory). ANCA specificity was assessed by a third generation ELISA kit for anti-PR3 and anti-MPO antibodies. Results: At disease presentation, the positivity rate of IIF-ANCA tests performed at the reference Immunology laboratory in the Federal University of São Paulo, Brazil was 32.3% in AAV, AIH and UC patients. Meanwhile, sera from the same patients tested by other laboratories using IIF-ANCA and ELISA yielded a higher positivity rate of 75.0% and 72.7%, respectively. Modifications in the IIF-ANCA technique were performed and serum samples were tested in pairs for the traditional and modified IIF-ANCA technique. Patients were analyzed regardless of the disease activity status. A significantly increase in the positivity rate (14.8% vs. 34.3%; p=0.0002) and median ANCA titers [1/40 (1/30 – 1/160) vs. 1/80 (1/40-1/80); p=0.0003] were observed in AAV, AIH and UC patients. UC had the highest increment in positive IIF-ANCA results from 5.3% to 36.8%. The positivity rate of PR3-ANCA and MPO-ANCA was not associated with the positivity of the IIF-ANCA technique. Conclusions: Adjustments in the IIF-ANCA protocol led to a significant improvement in the positivity rate and on ANCA titers in AAV, AIH and UC patients. Nonetheless, there was poor agreement between MPO- or PR3-ANCA and both IIF-ANCA techniques. Disclosures: None.
Hidden Selectivity: Irregular Migrants and Access to Socio-Health Services in a Heated Local Context
Creators: name: Bracci, Fabio
name: Valzania, Andrea
Publisher: name: Cambio. Rivista sulle Trasformazioni Sociali
Year: 2016

description: Irregular migrations and access to social and health services by undocumented migrants has become a very relevant issue in the Italian public discussion about migration policies in the last years. On one hand, the criminalisation of irregular migration has been feeding xenophobic policies; on the other hand, the regional law on immigration in the Region of Tuscany has been trying to put forward an alternative model. By declaring the right of irregular migrants to access basic socio-health services, the Region of Tuscany enacted a radical opposition to the National Immigration Law. In such a context, what happens when irregular migrants meet public services, and in particular, social and health services, in a local area characterised by a significant number of migrants? The following reflections deal with the municipality of Prato: since the end of the 1980s, this city has become the settlement area of a high number of migrants coming from many different countries. The paper underlines both the lack of efficacy of policies merely inspired to repressive goals and the very influential role played by operators within the public sector and non-profit associations in dealing with ambiguous, informal, and unclear domains of intervention. In a context marked by a growing disengagement of the public sector toward marginal and vulnerable people (like, in many cases, irregular migrants), the time has come to impose a new commitment for the public sector and draw a different way of considering the needs of irregular migrants.
description: Cambio. Rivista sulle Trasformazioni Sociali, Vol. 5 No. 10 (2015)
Survival Benefit with Kidney Transplants from HLA-Incompatible Live Donors
Creators: name: Bozorgzadeh,
name: Segev,
name: Oberholzer,
name: Jordan,
name: Stegall,
name: Gaber,
name: Marsh,
name: Rees,
name: Posner,
name: Ratner,
name: El-Amm,
name: Van Arendonk,
name: Cooper,
name: Sankari,
name: Lonze,
name: Shapiro,
name: Dunn,
name: Luo,
name: Sudan,
name: Montgomery,
name: Ahmed,
name: Wellen,
name: Nelson,
name: Kapur,
name: Massie,
name: Melcher,
name: Gerber,
name: Orandi,
name: Singh,
name: Pelletier,
name: Garonzik-Wang,
name: Lipkowitz,
name: Roberts,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: A report from a high-volume single center indicated a survival benefit of receiving a kidney transplant from an HLA-incompatible live donor as compared with remaining on the waiting list, whether or not a kidney from a deceased donor was received. The generalizability of that finding is unclear.
13. Clustering of anti-neutrophil cytoplasmic antibody-associated vasculitis - using a pre-processed harmonised dataset
Creators: name: Gisslander1, Karl
name: White2, Arthur
name: Segelmark3, Mårten
name: Little4, Mark A.
name: Aladdin J. Mohammad1, 5
Publisher: name: Zenodo
Year: 2022
Subjects: Vasculitis
ANCA
Abstracts
Giant Cell Arthritis
MPA
GPA
EGPA
Takayasu
IgA vasculitis

description: Background: The sub-classification of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) has been a long-standing debate. Unsupervised learning has previously been used for partitioning of phenotypic groups, but as AAV is a rare disease, small sample sizes have been a limiting factor. Here we attempt clustering of a small dataset harmonised to the FAIRVASC ontology, allowing potential future inclusion of an additional 6000 AAV patients from the FAIRVASC collaboration registries to the cluster model. FAIRVASC is a research project seeking to federate AAV registries across Europe using semantic web technologies (https://fairvasc.eu). Methods: This study used a dataset of 292 patients from southern Sweden, classified as granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA), according to the European Medicines Agency algorithm. The dataset was pre-processed from a relational database format to a resource descriptive framework (RDF) graph-based data model, harmonising the dataset to a FAIRVASC standard. Factor analysis of mixed data (FAMD) and agglomerative hierarchical cluster analysis on principal components (HCPC) was used to develop a cluster model, including organ pattern, ANCA status, serum creatinine, C-reactive protein, gender, and age at diagnosis. The generated clusters were evaluated by baseline characteristics, mortality, and renal outcome. Results: The analyses involved data for 163 subjects with GPA and 129 with MPA. The clustering model resulted in two larger clusters and three smaller ones. The larger clusters were a predominantly anti-PR3 positive cluster of young (mean 57.5 years at diagnosis) patients with ear-nose-throat involvement and a favourable outcome (Cluster 1), and a predominantly anti-MPO positive cluster with severe kidney involvement and high rates of mortality and end-stage kidney disease (Cluster 5). The three smaller clusters differed in terms of organ involvement and ANCA status at diagnosis, one with severe lung and renal involvement and a poor outcome (Cluster 3) and two with similar outcome, one ANCA negative (Cluster 4), and one with peripheral nerve involvement (Cluster 2). The descriptive characteristics of the clusters are presented in table 1. Conclusions: Our analysis suggests five clusters of AAV patients based on baseline features, associated with different mortality and renal outcome. The investigation acts as a proof of concept of the FAIRVASC ontology and infrastructure for the harmonisation of heterogeneous AAV datasets. The cluster model may in the future readily include an unprecedented number of European AAV patients. Disclosures: None
Sisyrinchium sinuosum Ravenna, Onira
Creators: name: Chocarro, María Del Carmen Peña
name: Egea, Juana De
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Iridaceae
Sisyrinchium
Sisyrinchium sinuosum

description: Sisyrinchium sinuosum Ravenna, Onira 8: 49. 2003.
Herb.
 Vouchers: Caaguazú: (Zuloaga et al. 2015). Canindeyú: Schinini 36124, type (CTES).
description: Published as part of Chocarro, María Del Carmen Peña & Egea, Juana De, 2018, Checklist of the endemic vascular plants of Paraguay, pp. 448-450 in Phytotaxa 384 (1) on pages 448-450, DOI: 10.11646/phytotaxa.384.1.1, http://zenodo.org/record/13725946
Il castello di carte. La transizione all'età adulta dei giovani Neet a Roma
Creators: name: Nerli Ballati, Enrico
name: Köhler, Jan
Publisher: name: Cambio. Rivista sulle Trasformazioni Sociali
Year: 2016

description: The paper focuses on the transition to adulthood of young people not in education, employment or training (NEETs). In the Italian context, unemployment, inactivity and problematic transitions to work are strongly related to delayed transition to adulthood and patterns of dependency on family. Our study aims to identify pathways to adulthood of NEETs from a biographical perspective. We carry out a software-based qualitative content analysis on 32 in-depth interviews, which have been conducted with NEETs between 25 and 34 years old in Rome and its surroundings as a part of a research project founded by Sapienza University of Rome. An empirically grounded typology of transition to adulthood based on position in the household, biographical sequence of life events and subjective aspirations for autonomy is constructed and six types are presented and characterized regarding dependency patterns, expectations for the future and subjective strategies to leave NEET-condition.
description: Cambio. Rivista sulle Trasformazioni Sociali, Vol. 5 No. 10 (2015)
12. Negative vs. Positive Antineutrophil Cytoplasmic Antibody Granulomatosis with Polyangiitis: A Case-Control Study
Creators: name: Moura, Marta Casal
name: Falde, Samuel
name: Specks, Ulrich
name: Baqir, Misbah
Publisher: name: Zenodo
Year: 2022
Subjects: Vasculitis
ANCA
Abstracts
Giant Cell Arthritis
MPA
GPA
EGPA
Takayasu
IgA vasculitis

description: Objectives: To characterize clinical features, management and outcomes of ANCA-negative GPA patients in comparison to age and sex matched patients with ANCA-positive GPA, and to describe patients who seroconverted from ANCA-negative to ANCA-positive GPA. Methods: We conducted a single-center, sex and age matched case-control with ANCA-negative vs. ANCA-positive GPA evaluated at our institution from January 1, 1996, to December 31, 2015. We also performed a case crossover study of the seroconverts. Clinical data and outcomes were retrospectively abstracted from electronic medical records. Results: We identified 110 patients with ANCA-negative GPA, predominantly female (65%) with median age of 55 (IQR 39-65) years at time of diagnosis. Disease severity was milder in ANCA-negative GPA (BVAS/WG score = 2 vs. 6, p<0.0001). Mucous membranous/eye manifestations were more frequent in ANCA-negative GPA, whereas general symptoms (arthralgias, fever, weight loss, myalgias), pulmonary, and renal involvement were more frequent in ANCA-positive GPA. ANCA-positive GPA patients relapsed more at 60 months (21.8% vs. 9.1%, p=0.009) compared to ANCA-negative GPA and had a shorter time to event (p=0.043). Patients with general manifestations, BMI > 30 kg/m2 and necrotizing granulomatous inflammation were more likely to relapse. In 16 ANCA seroconverts, patients had higher mean BVAS/WG score (p<0.0001), and increased incidence of relapses (p=0.004) after the seroconversion. Necrotizing granulomatous inflammation on biopsy in ANCA-negative GPA patients was identified as a risk factor for ANCA-positive seroconversion. Conclusion:  ANCA-negative GPA patients have milder disease and decreased frequency of relapse. ANCA seroconversion portends higher disease severity and an increased frequency of relapses. Disclosures: U. Specks received consulting fees from AstraZeneca, ChemoCentryx and research grants from AstraZeneca, GSK, Bristol Myers Squibb, Genentech. Table 1. Clinical characteristics and outcomes of patients with ANCA negative Granulomatosis with Polyangiitis (GPA) who seroconverted into positive ANCA GPA (n=16).
Airway Mucin Concentration as a Marker of Chronic Bronchitis
Creators: name: Radicioni, Giorgia
name: Boucher, Richard C.
name: Kanner, Richard E.
name: Ceppe, Agathe
name: Doerschuk, Claire M.
name: Anderson, Wayne H.
name: Ford, Amina A.
name: Paine, Rober
name: Han, MeiLan K.
name: Cooper, Christopher B.
name: Hansel, Nadia N.
name: Kesimer, Mehmet
name: Hoffman, Eric A.
name: Martinez, Fernando
name: Alexis, Neil E.
name: Bleecker, Eugene R.
name: Christenson, Stephanie A.
name: Henderson, Ashley G.
name: O'Neal, Wanda K.
name: Barr, Graham R.
name: Hastie, Annette T.
name: Davis, C. William
name: Cao, Rui
name: Woodruff, Prescott G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Chronic obstructive pulmonary disease (COPD) is characterized by chronic bronchitic and emphysematous components. In one biophysical model, the concentration of mucin on the airway surfaces is hypothesized to be a key variable that controls mucus transport in healthy persons versus cessation of transport in persons with muco-obstructive lung diseases. Under this model, it is postulated that a high mucin concentration produces the sputum and disease progression that are characteristic of chronic bronchitis.
Associations between affect and alcohol consumption in adults: an ecological momentary assessment study
Creators: name: Duif, Mira
name: Thewissen, Viviane
name: Wouters, Saskia
name: Lechner, Lilian
name: Jacobs, Nele
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Mental Health

description: Background: Consuming alcohol for coping with negative affect (NA) or enhancing positive affect (PA) may lead to risky drinking patterns. Previous research has yielded mixed findings regarding these affective drinking associations. Objectives: To examine support for the self-medication and expectancy models of alcohol use in an adult community sample, by examining reciprocal associations between alcohol consumption and NA and PA within and between persons. Methods: During seven consecutive days, 162 adults from the community (109 female) reported their affective experiences and alcohol consumption, following a signal contingent ecological momentary assessment protocol on their smartphones. Results: Within-person daily NA preceding the first drinking event was associated with increased likelihood of same-day alcohol consumption. Within-person momentary NA was associated with a decrease in the amount of next-moment alcohol consumption. Within-person momentary PA was positively associated with likelihood of next-moment alcohol consumption. Between persons, levels of daily and momentary NA and PA were not associated with any index of alcohol consumption. The intercepts and slopes of NA were not significantly different before and after alcohol consumption. The intercept of PA was higher after alcohol consumption, whereas the slope of PA decreased after alcohol consumption. Conclusion: In the current sample affective drinking was a within-person process (i.e. persons were sensitive to their varying levels of affect). Some support was found for the self-medication and expectancy models. People may drink for coping with NA, but may also be at risk for developing affective drinking patterns in response to PA.
La crisi greca: un'insolita lettura. Intervista a Manos Matsaganis
Creators: name: Giovannini, Paolo
name: Perulli, Angela
Publisher: name: Cambio. Rivista sulle Trasformazioni Sociali
Year: 2016

description: Cambio. Rivista sulle Trasformazioni Sociali, Vol. 5 No. 10 (2015)
“Not shifting, but sharing”: stakeholders’ perspectives on mental health task-shifting in Indonesia
Creators: name: Efendi, Ferry
name: Aurizki, Gading Ekapuja
name: Yusuf, Ah.
name: McKenna, Lisa
Publisher: name: figshare
Year: 2022
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Background: Task-shifting, the distribution of tasks among health workers to address health workforce shortage, has been widely used to tackle mental health treatment gaps. However, its implementation in Indonesia has still been rarely explored. This study aimed to explore stakeholders’ perspectives on the implementation of mental health taskshifting to nurses in Indonesia’s primary health care. Methods: An exploratory descriptive approach using in-depth interviews and focused group discussions (FGDs) was used. The study involved 19 stakeholders from the government’s ministry directorates, professional organisations, and mental health practitioners. Thematic analysis was used to analyse the data. Results: Three themes emerged namely, task-shifting feasibility and acceptability, shared task implementation, and nurse role enhancement issues, with 14 sub-themes. Conclusions: Task-shifting on mental health issues in the eye of Indonesian stakeholders is viewed as a matter of sharing and collaboration. Implementation of task-shifting in Indonesia may require policies in place and political will across stakeholders. Further scrutiny on task-shifting implementation is needed by considering the local context and national environment.
11. Characteristics of Inflammatory Arthritis in Polyarteritis Nodosa
Creators: name: Sullivan, Megan
name: Abril, Andy
Publisher: name: Zenodo
Year: 2022
Subjects: Vasculitis
ANCA
Abstracts
Giant Cell Arthritis
MPA
GPA
EGPA
Takayasu
IgA vasculitis

description: Background: Polyarteritis nodosa is a small to medium vessel vasculitis that can be limited to cutaneous manifestations or occur as a systemic disorder. Arthralgia has widely been reported in polyarteritis nodosa, but true inflammatory arthritis is seemingly rare in the literature. When inflammatory arthritis does occur, it has been reported to have a predilection for the lower extremities and treatment options are unclear. We report on a case series of 22 patients with a co-diagnosis of cutaneous polyarteritis nodosa and inflammatory arthritis. Methods: Advanced Text Explorer software was utilized to identify chart notes that contained the phrases “cutaneous polyarteritis nodosa” and “inflammatory arthritis”. A thorough chart review was conducted on the 34 resulting patients. Twelve patients did not have a diagnosis of cutaneous polyarteritis nodosa and/or a diagnosis of inflammatory arthritis so were excluded. The charts were then reviewed for pertinent demographic information, clinical history, lab values, pathology, synovial fluid analysis, and imaging results. Results: Of the 22 patients included, 16 (72.7%) were female with an average age of 40 at diagnosis (18-78). The arthritis most often involved the ankles (91.3%), followed by feet (43%), hands and wrists (35% each), and sacroiliitis/low back (13%). Six of the patients (27%) had erosive disease. In 77.7% of the patients cutaneous PAN preceded the inflammatory arthritis or co-occurred. Average time between diagnoses was 4.25 years. C-reactive protein was elevated in 10 (45%) and ESR in 5 (23%). ANA was positive in 23% and ANCA in 14%. Treatments varied widely with success reported most often using methotrexate (positive response in 7 of 10 patients treated). The average number of treatments utilized at the time of last follow-up was 3.4. Conclusions: Inflammatory arthritis in association with polyarteritis nodosa has a predilection to begin in the ankles and progresses to an oligoarthritis that can be difficult to treat with current immunosuppressive medications. Further research into the pathophysiology and treatment options of this oligoarthritis are indicated.
A $\sim$32-70 K formation temperature range for the ice grains agglomerated by comet 67P/Churyumov-Gerasimenko
Creators: name: Lectez, S.
name: Simon, J. M.
name: Mousis, O.
name: Picaud, S.
name: Altwegg, K.
name: Rubin, M.
name: Salazar, J. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Grand Canonical Monte Carlo simulations are used to reproduce the N$_2$/CO ratio ranging between 1.7 $\times$ 10$^{-3}$ and 1.6 $\times$ 10$^{-2}$ observed {\it in situ} in the Jupiter family comet 67P/Churyumov-Gerasimenko by the ROSINA mass spectrometer aboard the Rosetta spacecraft, assuming that this body has been agglomerated from clathrates in the protosolar nebula. Simulations are done using an elaborated interatomic potentials for investigating the temperature dependence of the trapping within a multiple guest clathrate formed from a gas mixture of CO and N$_2$ in proportions corresponding to those expected for the protosolar nebula. By assuming that 67P/Churyumov-Gerasimenko agglomerated from clathrates, our calculations suggest the cometary grains must have been formed at temperatures ranging between $\sim$31.8 and 69.9 K in the protosolar nebula to match the N$_2$/CO ratio measured by the ROSINA mass spectrometer. The presence of clathrates in Jupiter family comets could then explain the potential N$_2$ depletion (factor up to $\sim$87 compared to the protosolar value) measured in 67P/Churyumov-Gerasimenko.
description: Accepted for publication in The Astrophysical Journal Letters
Dysregulation of Lipid Metabolism in Mkp-1 Deficient Mice during Gram-Negative Sepsis
Creators: name: Li, Jinhui
name: Wang, Xiantao
name: Ackerman, William
name: Batty, Abel J
name: Kirk, Sean G
name: White, William M
name: Wang, Xianxi
name: Anastasakis, Dimitrios
name: Samavati, Lobelia
name: Buhimschi, Irina
name: Nelin, Leif D
name: Hafner, Markus
name: Liu, Yusen
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Mitogen-activated protein kinase phosphatase (Mkp)-1 exerts its anti-inflammatory activities during Gram-negative sepsis by deactivating p38 and c-Jun N-terminal kinase (JNK). We have previously shown that Mkp-1+/+ mice, but not Mkp-1-/- mice, exhibit hypertriglyceridemia during severe sepsis. However, the regulation of hepatic lipid stores and the underlying mechanism of lipid dysregulation during sepsis remains an enigma. To understand the molecular mechanism underlying the sepsis-associated metabolic changes and the role of Mkp-1 in the process, we infected Mkp-1+/+ and Mkp-1-/- mice with Escherichia coli i.v., and assessed the effects of Mkp-1 deficiency on tissue lipid contents. We also examined the global gene expression profile in the livers via RNA-seq. We found that in the absence of E. coli infection, Mkp-1 deficiency decreased liver triglyceride levels. Upon E. coli infection, Mkp-1+/+ mice, but not Mkp-1-/- mice, developed hepatocyte ballooning and increased lipid deposition in the livers. E. coli infection caused profound changes in the gene expression profile of a large number of proteins that regulate lipid metabolism in wildtype mice, while these changes were substantially disrupted in Mkp-1-/- mice. Interestingly, in Mkp-1+/+ mice E. coli infection resulted in downregulation of genes that facilitate fatty acid synthesis but upregulation of Cd36 and Dgat2, whose protein products mediate fatty acid uptake and triglyceride synthesis, respectively. Taken together, our studies indicate that sepsis leads to a substantial change in triglyceride metabolic gene expression programs and Mkp-1 plays an important role in this process.
Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease
Creators: name: Alvarez, Ofelia A.
name: Gordeuk, Victor R.
name: Cancado, Rodolfo
name: Liles, Darla
name: Smith, Wally R.
name: Gualandro, Sandra
name: Kanter, Julie
name: Rollins, Scott A.
name: Guthrie, Troy H.
name: Stocker, Jonathan W.
name: Kutlar, Abdullah
name: Friedrisch, João
name: Ataga, Kenneth I.
name: Knight-Madden, Jennifer
name: Rother, Russell P.
name: Colella, Marina P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: The up-regulation of P-selectin in endothelial cells and platelets contributes to the cell–cell interactions that are involved in the pathogenesis of vaso-occlusion and sickle cell–related pain crises. The safety and efficacy of crizanlizumab, an antibody against the adhesion molecule P-selectin, were evaluated in patients with sickle cell disease.
Incentivizing university students to quit smoking: a randomized controlled trial of a contingency management intervention in a developing country
Creators: name: Hofmeyr, Andre
name: Kincaid, Harold
name: Rusch, Olivia
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Mental Health

description: Background: Contingency management (CM) is an empirically supported behavioral treatment for tobacco use, but its efficacy with university student smokers in a developing country is unknown. Objectives: We evaluate a randomized controlled trial of a CM smoking cessation program conducted on a sample of treatment-seeking student smokers at the University of Cape Town. Methods: The study included a recruitment period, a 6-week intervention period, and a 6-month follow-up period. Subjects in the control group (information and monitoring; n = 47, 76% male) were given information to help them quit smoking and had their quit attempt monitored, receiving R50 ($8) at each assessment. Subjects in the treatment group (information and monitoring, plus CM; n = 40, 80% male) could additionally earn R150 ($24) in abstinence-contingent incentives at each assessment. Outcome variables: 7-day point-prevalence abstinence at 6 months and at the end of the intervention period, and a repeated measure of smoking intensity of non-abstinent subjects. Results: CM had no long-term effect on abstinence at 6 months but had a marked and statistically significant effect on the likelihood of abstinence by the end of the intervention period (p < .001). In addition, while CM did not affect smoking intensity, participation in the program decreased the average number of cigarettes smoked per day by non-abstainers (p < .001). Conclusions: The CM program was efficacious in promoting abstinence amongst treatment-seeking university students in a developing country but only while incentives were in place. Future research should focus on promoting continuous abstinence with this target sample.
EQUILIBRI DIGITALI – Identità nel caos contemporaneo
Creators: name: Di Feo, Maurizio
Publisher: name: Zenodo
Year: 2025

description: EQUILIBRI DIGITALI – Identità nel caos contemporaneo 15 aprile 2025 – Giornata Mondiale dell'Arte

Un catalogo del corso di Computer Grafica dell'Accademia di Belle Arti di Bari, a cura di Maurizio Di Feo e Giuliana Schiavone, con il patrocinio dell'Accademia.

Lavori degli studenti del biennio che esplorano identità, caos e AI tra disegno analogico e grafica digitale.

Acquistabile anche con Carta Cultura Giovani, Carta del Merito e Carta del Docente.

Introduzione: Direttore Antonio Cicchelli Coordinamento: Maurizio Di Feo Curatela: Giuliana Schiavone

Con opere di: Keyu Chen · Alessandro Colangelo · Carmen Lauriola · Giusi Mascolo · Maria Francesca Ritella · Pia Francesca Varano · Gabriele Zanna · Qingyi Zhang

 

EQUILIBRI DIGITALI – Identità nel caos contemporaneo

Codice ISBN: 979-8317178871
Cranichis hassleri Cogn., Repert. 2018, Spec. Nov.
Creators: name: Chocarro, María Del Carmen Peña
name: Egea, Juana De
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Cranichis
Cranichis hassleri

description: Cranichis hassleri Cogn., Repert. Spec. Nov. Regni Veg. 7: 69. 1909.
Herb.
 Vouchers: Amambay: Hassler & Rojas 10304, type (AMES, BM, BR, G, K, MPU, NY, P): Hassler & Rojas 10304a (G).
description: Published as part of Chocarro, María Del Carmen Peña & Egea, Juana De, 2018, Checklist of the endemic vascular plants of Paraguay, pp. 448-450 in Phytotaxa 384 (1) on pages 448-450, DOI: 10.11646/phytotaxa.384.1.1, http://zenodo.org/record/13725946
Normal Extensions of Representations of Abelian Semigroups
Creators: name: Li, Boyu
Publisher: name: arXiv
Year: 2015
Subjects: subject: Functional Analysis (math.FA)
subject: Operator Algebras (math.OA)
subject: FOS: Mathematics
subject: 47B20, 47A20, 47D03

description: A commuting family of subnormal operators need not have a commuting normal extension. We study when a representation of an abelian semigroup can be extended to a normal representation, and show that it suffices to extend the set of generators to commuting normals. We also extended a result due to Athavale to representations on abelian lattice ordered semigroups.
description: 10 pages
Aspects of Non-commutative Function Theory
Creators: name: Agler, Jim
name: McCarthy, John E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 15A54

description: We discuss non commutative functions, which naturally arise when dealing with functions of more than one matrix variable.
"Newborn". Kosovos secession: sui generis case or new doctrine on self-determination?
Creators: name: Grayeb Munayer, Jorge Alberto
Publisher: name: My University
Year: 2009
Subjects: international status
Kosovo
state-building
self-determination

description: Second semester University: University of Deusto, Bilbao
description: Kosovo’s secession has been treated as a sui generis case by States and many scholars. This contribution argues that instead of an exception, Kosovo should be taken as the contemporary example to advance the legal and political understanding of selfdetermination and secession in the post-decolonisation era. For instance, the ICJ could positively contribute to the latter through a progressive interpretation on its advisory opinion on Kosovo’s unilateral declaration of independence. Even if the legal implications of Kosovo’s secession can be more easily limited by States, its political subjectivity might contain a spill over effect difficult to contain. In that sense, Kosovo has a precedent-setting potential that should not be neglected. Kosovo’s independence could push for the extension of the right to selfdetermination (with the possibility of secession) even for minority groups in democratic contexts. It has contributed to reopen the debate on secession particularly at European level. For countries like Spain, the precedent-setting potential of Kosovo’s secession could disentangle obsolete debates, for example, in the Basque context. It could favour the development of innovative strategies to address claims for self-determination from less dogmatised perspectives.
title: Industrie 4.0-Lösungen zur Sammlung und Analyse von Produktionsdaten
Creators: name: Goudz, Alexander
name: Sapel, Patrick
Publisher: name: DuEPublico: Duisburg-Essen Publications Online, University of Duisburg-Essen, Germany
Year: 2018
Subjects: subject: Cloud Computing
subject: Datenanalyse
subject: Datensammlung
subject: Edge Compu-ting
subject: IIoT
subject: Industrial Internet of Things
subject: Industrie 4.0
subject: Nachrich-tenprotokolle
subject: OPC UA
subject: Predictive Maintenance

description: Die vierte industrielle Revolution (Industrie 4.0) bietet Unterneh-men enorme Chancen, sowohl ihre Kosten zu senken als auch ihre Erlöse zu steigern. Dies ist realisierbar durch die Vernetzung sämtlicher Maschinen, Lagersysteme und Betriebsmittel zu einem Cyber-Physischen-System (CPS). Das CPS kommuniziert dabei autonom, dezentral, online und in Echtzeit. Voraussetzung, um die Potentiale von Industrie 4.0 nutzen zu können, ist die Verarbei-tung von Daten, aus denen Wissen generiert wird. Durch dieses Wissen lassen sich dann Maßnahmen einleiten, welche die Ferti-gung effizient gestalten.

Damit diese Wissensgenerierung aus den Daten stattfinden kann, sind im ersten Schritt diese Rohdaten zu sammeln, zu transportie-ren und zu analysieren. Für diese Zwecke existiert eine Vielzahl von Protokollen, die für die unterschiedlichsten Rahmenbedin-gungen konzipiert worden sind. Folglich ist nicht jedes Protokoll für jedes Szenario geeignet. Vielmehr ist im Vorfeld genauestens zu eruieren, welche Anforderungen an das anzutreffende Szenario bestehen, um diejenige Kombination aus Protokollen zu wählen, die am besten zu dem Szenario passt. Bei der Auswahl von Proto-kollen ist stets darauf zu achten, dass diese im Industrie 4.0-Um-feld standardisiert sind, um aufwendige Translationen oder gar Inkompatibilitäten zwischen den Kommunikationsteilnehmern zu vermeiden. Die Auswahl der Protokolle hat letztendlich einen gro-ßen Einfluss auf die Qualität des Industrie 4.0-Prozesses, weshalb in dieser Publikation ausgewählte Protokolle untersucht und be-wertet werden.

Im Anschluss daran findet die Demonstration zweier konkrete In-dustrie 4.0-Anwendungsfälle statt, die zeigen sollen, welchen Mehrwert die gewonnenen Maschinendaten bieten können. Dabei handelt es sich um die vorausschauende Wartung (Predictive Maintenance), welches eine Methode zur Prognostizierung von Maschinenausfällen darstellt. Weiterhin soll gezeigt werden, dass die autonome Aktualisierung von Stammdaten zu einer transpa-renteren Fertigung beiträgt.

Umgesetzt und geprüft wurden diese Erkenntnisse auf einer Fer-tigungslinie der thyssenkrupp AG, wobei sowohl die Methoden der Datenextraktion als auch die geschilderten Industrie 4.0-Anwen-dungsfälle unabhängig vom Unternehmen implementierbar sind.
How to calculate quantum quench distributions with a weighted Wang-Landau Monte Carlo
Creators: name: Ziraldo, Simone
name: Santoro, Giuseppe E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: We present here an extension of the Wang-Landau Monte Carlo method which allows us to get very accurate estimates of the full probability distributions of several observables after a quantum quench for large systems, whenever the relevant matrix elements are calculable, but the full exponential complexity of the Hilbert space would make an exhaustive enumeration impossible beyond very limited sizes. We apply this method to quenches of free-fermion models with disorder, further corroborating the fact that a generalized Gibbs ensemble fails to capture the long-time average of many-body operators when disorder is present.
description: 18 pages, 6 figures, accepted for publication in JSTAT
Holographic RG Flow in a New $SO(3)\times SO(3)$ Sector of $ω$-Deformed $SO(8)$ Gauged ${\cal N}=8$ Supergravity
Creators: name: Pang, Yi
name: Pope, C. N.
name: Rong, Junchen
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We consider a certain ${\cal N}=1$ supersymmetric, $SO(3)\times SO(3)$ invariant, subsector of the $ω$-deformed family of $SO(8)$-gauged ${\cal N}=8$ four-dimensional supergravities. The theory contains two scalar fields and two pseudoscalar fields. We look for stationary points of the scalar potential, corresponding to AdS vacua in the theory. One of these, which breaks all supersymmetries but is nonetheless stable, is new. It exists only when $ω\ne 0$. We construct supersymmetric domain wall solutions in the truncated theory, and we give a detailed analysis of their holographic dual interpretations using the AdS/CFT correspondence. Domain walls where the pseudoscalars vanish were studied previously, but those with non-vanishing pseudoscalars, which we analyse numerically, are new. The pseudoscalars are associated with supersymmetric mass deformations in the CFT duals. When $ω$ is zero, the solutions can be lifted to M-theory, where they approach the Coulomb-branch flows of dielectric M5-branes wrapped on $S^3$ in the deep IR.
description: 40 pages, 10 figures
Il riconoscimento delle nuove forme di famiglia. Una controversa posta in gioco nella recente politica familiare in Francia
Creators: name: Letablier, Marie-Thérèse
Publisher: name: Cambio. Rivista sulle Trasformazioni Sociali
Year: 2016

description: This paper explores how the new family forms have been taken into account in the reshaping of the French family policy. Three recent reforms are examined through the analytical frame of familialism which was one of three drivers of the family policy when it was set up in the mid-20th century. Familialism allows for a consideration of both moral, social and gender order that is on families. Firstly, change in the family law is explored in order to assess how new family life arrangements are institutionalized. Secondly, family policy responses to the new social risks resulting from change in the family life course are explored. Then policy responses to change in the gender order within the family are examined. Difficulties in implementing the policy change are discussed, highlighting the obstacles encountered by the current government as well as the gap between the objectives and their implementation.
description: Cambio. Rivista sulle Trasformazioni Sociali, Vol. 5 No. 9 (2015)
Childhood lost at sea : detention of irregular minors in the Mediterranean European Union
Creators: name: Borghi, Paola
Publisher: name: My University
Year: 2008
Subjects: children
Greece
Italy
migrants

description: Second semester University: Panteion University, Athens
description: Dealing with the immigration phenomenon in Europe, the particular question of foreign minors in detention constitutes a real challenge in the European effort to combine migration containment with human rights standards. This study elaborates on the law and the practices regulating administrative detention of irregular minors at the European Union Southern maritime borders. The European Union framework and the specific case of Italy and Greece are analysed in the light of the international human rights protection against minors’ detention. The study focuses on the whole range of children’s human rights involved: protection against arbitrary detention, procedural rights, right to family life, to health, education and leisure. The main intention is to evaluate the effective value according to the principle of the best interest of the child when it comes to migration control policies and practices. The following questions are addressed. Do international and regional human rights instruments offer a fully protective system against children’s detention? Do national legislations comply with international and regional human rights obligations? Do the real practices reflect the standards set in the law? Comparing the legal framework with its implementation in the reality foreign children face at the Mediterranean borders, it’s the means to identify the limits to be overstepped in order to control migration flows in the respect of the rights and dignity of all children.
Epidendrum hassleri Cogn., Repert. 2018, Spec. Nov.
Creators: name: Chocarro, María Del Carmen Peña
name: Egea, Juana De
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Epidendrum
Epidendrum hassleri

description: Epidendrum hassleri Cogn., Repert. Spec. Nov. Regni Veg. 7: 70. 1909.
Epiphyte.
 Vouchers: Alto Paraná: Stutz 509 (G). Amambay: Brunner et al. 957 (G); Hassler & Rojas 10339, type (AS, G).
description: Published as part of Chocarro, María Del Carmen Peña & Egea, Juana De, 2018, Checklist of the endemic vascular plants of Paraguay, pp. 448-450 in Phytotaxa 384 (1) on pages 448-450, DOI: 10.11646/phytotaxa.384.1.1, http://zenodo.org/record/13725946
Nel best interest dei bambini e delle madri surrogate
Creators: name: Casalini, Brunella
Publisher: name: Cambio. Rivista sulle Trasformazioni Sociali
Year: 2016

description: The aim of this article is to provide a short overview of some recent decisions of the EctHR regarding children born to surrogate mothers abroad. These decisions have to be celebrated as they recognize the best interest of the child. They seem to live the member states with few options to enforce their legislation against surrogate motherhood arrangements once a child is born. Things so standing, it is suggested that states should consider the possibility of legalizing surrogate motherhood to avoid being complicit with global and local inequalities.
description: Cambio. Rivista sulle Trasformazioni Sociali, Vol. 5 No. 9 (2015)
9. Characterization of patients with normal inflammatory markers in giant cell arteritis
Creators: name: Zeeman, Michael
name: Chauhan, Uday
name: Clifford, Alison
Publisher: name: Zenodo
Year: 2022
Subjects: Vasculitis
ANCA
Abstracts
Giant Cell Arthritis
MPA
GPA
EGPA
Takayasu
IgA vasculitis

description: Objectives: Giant cell arteritis (GCA) is the most common form of vasculitis in people over the age of 50 years old. Inflammatory markers, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), are typically elevated at the time of diagnosis and prompt suspicion for this disease. Given the severe potential consequences of a missed diagnosis, we aimed to study the frequency and clinical correlation of normal inflammatory markers in patients with confirmed GCA. Methods: Electronic medical records of patients diagnosed with GCA by rheumatologists at the University of Alberta between April 2012 and December 2017 were retrospectively reviewed. For inclusion, patients must have 1) met ACR 1990 classification criteria for GCA, 2) had confirmed disease by either temporal artery biopsy or advanced imaging (PET/CT, MRA, CTA) and 3) had either ESR and/or CRP prior to glucocorticoid administration available. Patients were grouped according to the presence of either normal or elevated ESR or CRP (normal ESR defined as ≤25mm/hr, normal CRP as ≤8mg/L.) Groups with elevated versus normal inflammatory markers were compared with respect to demographics, symptoms, comorbidities, medications, and clinical outcomes. Results: Of 81 total GCA patients, 42 met above study inclusion (38 with available ESR, 41 with available CRP, and 37 with both.) Among confirmed cases, 21.6% of patients had either a normal ESR or CRP pre-treatment (21.1% with normal ESR, and 9.8% with normal CRP,) while 5.4% of patients had both normal ESR and CRP. See Table 1 for distribution of inflammatory markers observed. Upon limiting the sample to the 34 patients with biopsy-confirmed disease, 20.0% had either normal ESR or CRP and 6.7% had both normal markers. No significant differences in age, sex, comorbidities, or symptoms were observed between patients with elevated versus normal inflammatory markers. Patients with normal ESR were less likely to receive steroid-sparing agents than patients with elevated ESR (0.0% vs 50.0%, p=0.013), however, and were less likely to relapse (12.5% vs 56.7%, p=0.045). Conclusion: Twenty percent of biopsy- or imaging-confirmed GCA patients have either a normal ESR or CRP at diagnosis, and both tests are normal in 5-7% of patients. No clinical features reliably distinguish cases with normal inflammatory markers, but normal ESR may predict a lower risk of future relapse. These findings highlight the importance of routinely checking both ESR and CRP in cases of suspected GCA and maintaining a high index of suspicion in those with typical symptoms or signs. Disclosures: None.
Effects of Sotagliflozin Added to Insulin in Patients with Type 1 Diabetes
Creators: name: Peters, Anne
name: Fulcher, Gregory R.
name: Danne, Thomas
name: Garg, Satish K.
name: Simó, Rafael
name: Davies, Melanie J.
name: McGuire, Darren K.
name: Strumph, Paul
name: Henry, Robert R.
name: Pozzilli, Paolo
name: Banks, Phillip
name: Buse, John B.
name: Lapuerta, Pablo
name: Gesty-Palmer, Diane
name: Kushner, Jake A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: BACKGROUND: In most patients with type 1 diabetes, adequate glycemic control is not achieved with insulin therapy alone. We evaluated the safety and efficacy of sotagliflozin, an oral inhibitor of sodium-glucose cotransporters 1 and 2, in combination with insulin treatment in patients with type 1 diabetes.

METHODS: In this phase 3, double-blind trial, which was conducted at 133 centers worldwide, we randomly assigned 1402 patients with type 1 diabetes who were receiving treatment with any insulin therapy (pump or injections) to receive sotagliflozin (400 mg per day) or placebo for 24 weeks. The primary end point was a glycated hemoglobin level lower than 7.0% at week 24, with no episodes of severe hypoglycemia or diabetic ketoacidosis after randomization. Secondary end points included the change from baseline in glycated hemoglobin level, weight, systolic blood pressure, and mean daily bolus dose of insulin.

RESULTS: A significantly larger proportion of patients in the sotagliflozin group than in the placebo group achieved the primary end point (200 of 699 patients [28.6%] vs. 107 of 703 [15.2%], P<0.001). The least-squares mean change from baseline was significantly greater in the sotagliflozin group than in the placebo group for glycated hemoglobin (difference, -0.46 percentage points), weight (-2.98 kg), systolic blood pressure (-3.5 mm Hg), and mean daily bolus dose of insulin (-2.8 units per day) (P≤0.002 for all comparisons). The rate of severe hypoglycemia was similar in the sotagliflozin group and the placebo group (3.0% [21 patients] and 2.4% [17], respectively). The rate of documented hypoglycemia with a blood glucose level of 55 mg per deciliter (3.1 mmol per liter) or below was significantly lower in the sotagliflozin group than in the placebo group. The rate of diabetic ketoacidosis was higher in the sotagliflozin group than in the placebo group (3.0% [21 patients] and 0.6% [4], respectively).

CONCLUSIONS: Among patients with type 1 diabetes who were receiving insulin, the proportion of patients who achieved a glycated hemoglobin level lower than 7.0% with no severe hypoglycemia or diabetic ketoacidosis was larger in the group that received sotagliflozin than in the placebo group. However, the rate of diabetic ketoacidosis was higher in the sotagliflozin group. (Funded by Lexicon Pharmaceuticals; inTandem3 ClinicalTrials.gov number, NCT02531035 .).