cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Comprehensive Time-Series Regression Models Using GRETL -- U.S. GDP and Government Consumption Expenditures & Gross Investment from 1980 to 2013
Creators: name: Shi, Juehui
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Economics (econ.GN)
subject: Applications (stat.AP)
subject: FOS: Economics and business
subject: FOS: Computer and information sciences

description: Using Gretl, I apply ARMA, Vector ARMA, VAR, state-space model with a Kalman filter, transfer-function and intervention models, unit root tests, cointegration test, volatility models (ARCH, GARCH, ARCH-M, GARCH-M, Taylor-Schwert GARCH, GJR, TARCH, NARCH, APARCH, EGARCH) to analyze quarterly time series of GDP and Government Consumption Expenditures & Gross Investment (GCEGI) from 1980 to 2013. The article is organized as: (I) Definition; (II) Regression Models; (III) Discussion. Additionally, I discovered a unique interaction between GDP and GCEGI in both the short-run and the long-run and provided policy makers with some suggestions. For example in the short run, GDP responded positively and very significantly (0.00248) to GCEGI, while GCEGI reacted positively but not too significantly (0.08051) to GDP. In the long run, current GDP responded negatively and permanently (0.09229) to a shock in past GCEGI, while current GCEGI reacted negatively yet temporarily (0.29821) to a shock in past GDP. Therefore, policy makers should not adjust current GCEGI based merely on the condition of current and past GDP. Although increasing GCEGI does help GDP in the short-term, significantly abrupt increase in GCEGI might not be good to the long-term health of GDP. Instead, a balanced, sustainable, and economically viable solution is recommended, so that the short-term benefits to the current economy from increasing GCEGI often largely secured by the long-term loan outweigh or at least equal to the negative effect to the future economy from the long-term debt incurred by the loan. Finally, I found that non-normally distributed volatility models generally perform better than normally distributed ones. More specifically, TARCH-GED performs the best in the group of non-normally distributed, while GARCH-M does the best in the group of normally distributed.
description: 82 Pages with Gretl codes included
Molecular approaches for manipulating astrocytic signaling in vivo
Creators: name: Petravicz, Jeremy
name: McCarthy, Ken D.
name: Xie, Alison X.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Astrocytes are the predominant glial type in the central nervous system and play important roles in assisting neuronal function and network activity. Astrocytes exhibit complex signaling systems that are essential for their normal function and the homeostasis of the neural network. Altered signaling in astrocytes is closely associated with neurological and psychiatric diseases, suggesting tremendous therapeutic potential of these cells. To further understand astrocyte function in health and disease, it is important to study astrocytic signaling in vivo. In this review, we discuss molecular tools that enable the selective manipulation of astrocytic signaling, including the tools to selectively activate and inactivate astrocyte signaling in vivo. Lastly, we highlight a few tools in development that present strong potential for advancing our understanding of the role of astrocytes in physiology, behavior, and pathology.
A facile synthesis of a novel family of heterotricyclic hybrids: Spiro-pyrrolopyridazines
Creators: name: Dundar, Buse Aysen
name: Zora, Metin
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: An efficient strategy for the synthesis of spiro-pyrrolopyridazines has been developed. When reacted with hydrazine monohydrate, spiro-2H-pyrroles with a 1,4-diketone functionality produced a novel family of heterotricyclic hybrids, spiro-pyrrolopyridazines, specifically spiro{cyclohexane-1,5'-pyrrolo[3,4-d]pyridazine} systems. The condensation reaction of spiro-2H-pyrroles with hydrazine monohydrate in refluxing 1-butanol proceeded well and afforded spiro-pyrrolopyridazines in good to high yields. The reaction was found to be general for variety of spiro-2H-pyrroles and demonstrated good tolerance to a variety of aromatic and heteroaromatic groups with electron-withdrawing and electron-donating substituents. The synthesis of heterotricyclic spiro-pyrrolopyridazine hybrids may exhibit potential to deliver diverse structural motifs that aid the drug discovery efforts.
Development of methods for cellobiose and mannitol in urine
Creators: name: Blood, Jane
Publisher: name: Loughborough University
Year: 2019
Subjects: subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Differential absorption of probe molecules, such as cellobiose and mannitol, has been used for the diagnosis and monitoring of patients with coeliac disease. After an oral dose of cellobiose and mannitol, the patient collects all urine passed for 5 hours. The urinary recoveries of cellobiose and mannitol are measured and expressed as a ratio which gives an indication of intestinal permeability. [Continues.]
การเล่นทางภาษาในบทสนทนามุกตลกชวนขัน
Creators: name: สุวรรณา งามเหลือ
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2021
Subjects: การเล่นทางภาษา
บทสนทนา
มุกตลกชวนขัน

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 21, 1, 440-458
A scattering model of 1D quantum wire regular polygons
Creators: name: Estarellas, Cristian
name: Serra, Llorenç
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We calculate the quantum states of regular polygons made of 1D quantum wires treating each polygon vertex as a scatterer. The vertex scattering matrix is analytically obtained from the model of a circular bend of a given angle of a 2D nanowire. In the single mode limit the spectrum is classified in doublets of vanishing circulation, twofold split by the small vertex reflection, and singlets with circulation degeneracy. Simple analytic expressions of the energy eigenvalues are given. It is shown how each polygon is characterized by a specific spectrum.
description: 8 pages, 5 figures
Stimulating somatosensory psychophysics: a double-blind, sham-controlled study of the neurobiological mechanisms of tDCS
Creators: name: Hanley, Claire J.
name: Tommerdahl, Mark
name: McGonigle, David J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The neuromodulation technique transcranial direct current stimulation (tDCS) is thought to produce its effects on behavior by altering cortical excitability. Although the mechanisms underlying the observed effects are thought to rely on the balance of excitatory and inhibitory neurotransmission, the physiological principles of the technique are not completely understood. In this study, we examine the influence of tDCS on vibrotactile adaptation, using a simple amplitude discrimination paradigm that has been shown to exhibit modifications in performance due to changes in inhibitory neurotransmission. Double-blind tDCS (Anodal/Sham) of 1 mA was delivered for 600 s to electrodes positioned in a somatosensory/contralateral orbit montage. Stimulation was applied as part of a pre/post design, between blocks of the behavioral tasks. In accordance with previous work, results obtained before the application of tDCS indicated that amplitude discrimination thresholds were significantly worsened during adaptation trials, compared to those achieved at baseline. However, tDCS failed to modify amplitude discrimination performance. Using a Bayesian approach, this finding was revealed to constitute substantial evidence for the null hypothesis. The failure of DC stimulation to alter vibrotactile adaptation thresholds is discussed in the context of several factors that may have confounded the induction of changes in cortical plasticity.
Synthesis of highly substituted pyrimidine fused uracils by PhI(OAc)2/TEMPO-catalyzed oxidative insertion of alcohols into N-uracil amidines
Creators: name: Debnath, Pradip
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology

description: An efficient and sustainable organocatalyst-catalyzed protocol for the synthesis of structurally diverse pyrimidine fused uracils via the oxidative insertion of alcohols into N-uracil amidines has been developed. With 1.2 equiv. of PhI(OAc)2 in combination with 10 mol% of TEMPO as the catalyst and Cs2CO3 as the base, this protocol has been applied to synthesize a small library of pyrimidine fused uracils in high yields. The PhI(OAc)2/TEMPO-catalyzed oxidation of alcohol in-situ generated an aldehyde intermediate, which is subsequently reacted with N-uracil amidine to provide the highly functionalized pyrimidine fused uracils. The protocol is operationally simple, and applicable to a broad range of alcoholic substrates, making it highly practical approach for the preparation of pyrimidine fused uracils of biological significance.
Decoupling the scholarly journal
Creators: name: Hemminger, Bradley M.
name: Priem, Jason
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Although many observers have advocated the reform of the scholarly publishing system, improvements to functions like peer review have been adopted sluggishly. We argue that this is due to the tight coupling of the journal system: the system's essential functions of archiving, registration, dissemination, and certification are bundled together and siloed into tens of thousands of individual journals. This tight coupling makes it difficult to change any one aspect of the system, choking out innovation. We suggest that the solution is the “decoupled journal (DcJ).” In this system, the functions are unbundled and performed as services, able to compete for patronage and evolve in response to the market. For instance, a scholar might deposit an article in her institutional repository, have it copyedited and typeset by one company, indexed for search by several others, self-marketed over her own social networks, and peer reviewed by one or more stamping agencies that connect her paper to external reviewers. The DcJ brings publishing out of its current seventeenth-century paradigm, and creates a Web-like environment of loosely joined pieces—a marketplace of tools that, like the Web, evolves quickly in response to new technologies and users' needs. Importantly, this system is able to evolve from the current one, requiring only the continued development of bolt-on services external to the journal, particularly for peer review.
N-tosylhydrazones as acceptors for nucleophilic alkyl radicals in photoredox catalysis: A short case study on possible side reactions
Creators: name: Kinsella, Anna G.
name: Tibbetts, Joshua D.
name: Stead, Darren
name: Cresswell, Alexander J.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: We report the attempted development of a photoredox-catalyzed α-C–H alkylation reaction of aliphatic amine derivatives, using N-tosylhydrazones as radical alkylating partners. The original intention was to intercept α-aminoalkyl radical intermediates with N-tosylhydrazones, followed by the expulsion of a sulfonyl radical by β-scission to generate N-H diazene species. Facile denitrogenation of these intermediates would remove all traces of the hydrazone moiety and provide a net C–H alkylation process. However, our plans were derailed by issues with the low reactivity of N-tosylhydrazones toward intermolecular capture by nucleophilic radicals, and several unexpected side reactions. Our findings, though unsuccessful, do serve to identify challenges for future researchers attempting to develop similar transformations.
Strong asymptotic arbitrage in the large fractional binary market
Creators: name: Cordero, Fernando
name: Perez-Ostafe, Lavinia
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60G22, 60G40, 60G50, 91B24, 91B26

description: We study, from the perspective of large financial markets, the asymptotic arbitrage opportunities in a sequence of binary markets approximating the fractional Black-Scholes model. This approximating sequence was introduced by Sottinen and named fractional binary market. The large financial market under consideration does not satisfy the standard assumptions of the theory of asymptotic arbitrage. For this reason, we follow a constructive approach to show first that a strong type of asymptotic arbitrage exists in the large market without transaction costs. Indeed, with the help of an appropriate version of the law of large numbers and a stopping time procedure, we construct a sequence of self-financing strategies, which leads to the desired result. Next, we introduce, in each small market, proportional transaction costs, and we construct, following a similar argument, a sequence of self-financing strategies providing a strong asymptotic arbitrage when the transaction costs converge fast enough to 0.
description: 21 pages
Environmental and Genetic Contributors to Salivary Testosterone Levels in Infants
Creators: name: Xia, Kai
name: Zhu, Hongtu
name: Gilmore, John H.
name: Yu, Yang
name: Ahn, Mihye
name: Zou, Fei
name: Knickmeyer, Rebecca C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Transient activation of the hypothalamic–pituitary–gonadal axis in early infancy plays an important role in male genital development and sexual differentiation of the brain, but factors contributing to individual variation in testosterone levels during this period are poorly understood. We measured salivary testosterone levels in 222 infants (119 males, 103 females, 108 singletons, 114 twins) between 2.70 and 4.80 months of age. We tested 16 major demographic and medical history variables for effects on inter-individual variation in salivary testosterone. Using the subset of twins, we estimated genetic and environmental contributions to salivary testosterone levels. Finally, we tested single nucleotide polymorphisms (SNPs) within ±5 kb of genes involved in testosterone synthesis, transport, signaling, and metabolism for associations with salivary testosterone using univariate tests and random forest (RF) analysis. We report an association between 5 min APGAR scores and salivary testosterone levels in males. Twin modeling indicated that individual variability in testosterone levels was primarily explained by environmental factors. Regarding genetic variation, univariate tests did not reveal any variants significantly associated with salivary testosterone after adjusting for false discovery rate. The top hit in males was rs10923844, an SNP of unknown function located downstream of HSD3B1 and HSD3B2. The top hits in females were two SNPs located upstream of ESR1 (rs3407085 and rs2295190). RF analysis, which reflects joint and conditional effects of multiple variants, indicated that genes involved in regulation of reproductive function, particularly LHCGR, are related to salivary testosterone levels in male infants, as are genes involved in cholesterol production, transport, and removal, while genes involved in estrogen signaling are related to salivary testosterone levels in female infants.
An improved procedure for the synthesis of fourteen 4-OH and 3-MeO-4OH metabolites of fentanyl analogues from two intermediates on multi-gram scale
Creators: name: Rautio, Tobias
name: Thornell, Jonathan
name: Gréen, Henrik
name: Konradsson, Peter
name: Dahlén, Johan
name: Wu, Xiongyu
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Fentanyl analogues have appeared on the recreational drug market during the last ten years and caused many fatal overdoses around the world due to their high potencies. Their metabolites are of great interest for toxicology, metabolism and identification studies. According to the literature, fentanyl analogues with similar structures have similar metabolism profile. Therefore, a synthetic route that enables synthesis of the corresponding metabolites for several fentanyl analogues would be valuable. Fentanyl analogue metabolites are often polar and tailing on silica gel. Hence, the purification of these substances could be challengeable. In this work, a general synthetic route was developed and described for the multi-gram scale synthesis of 14 potential metabolites of seven fentanyl analogues. The synthetic route is concise and optimized, does not require any use of silica gel purification and is therefore convenient for large-scale synthesis. The overall yields of the metabolites were in the range of 25–57%.
The Role of the Insulin/IGF System in Cancer: Lessons Learned from Clinical Trials and the Energy Balance-Cancer Link
Creators: name: Rossi, Emily L.
name: deGraffenried, Linda A.
name: Bowers, Laura W.
name: Hursting, Stephen D.
name: Oâ€™Flanagan, Ciara H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Numerous epidemiological and pre-clinical studies have demonstrated that the insulin/insulin-like growth factor (IGF) system plays a key role in the development and progression of several types of cancer. Insulin/IGF signaling, in cooperation with chronic low-grade inflammation, is also an important contributor to the cancer-promoting effects of obesity. However, clinical trials for drugs targeting different components of this system have produced largely disappointing results, possibly due to the lack of predictive biomarker use and problems with the design of combination therapy regimens. With careful attention to the identification of likely patient responders and optimal drug combinations, the outcome of future trials may be improved. Given that insulin/IGF signaling is known to contribute to obesity-associated cancer, further investigation regarding the efficacy of drugs targeting this system and its downstream effectors in the obese patient population is warranted.
การวิเคราะห์ข้อผิดในงานเขียนภาษาญี่ปุ่นของผู้เรียนชาวไทย ชั้นต้น
Creators: name: สุณีย์รัตน์ เนียรเจริญสุข
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2021
Subjects: ทักษะการเขียนภาษาญี่ปุ่น
การวิเคราะห์ข้อผิด
การถ่ายโอนเชิงลบ
การสรุปเกินการ

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 21, 2, 1-29
Smooth Bounce in Affine Quantization of Bianchi I
Creators: name: Bergeron, Herve
name: Dapor, Andrea
name: Gazeau, Jean-Pierre
name: Malkiewicz, Przemyslaw
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We present the affine coherent state quantization of the Bianchi I model. As in our previous paper on quantum theory of Friedmann models, we employ a variable associated with a perfect fluid to play a role of clock. Then we deparameterize the model. A distinctive feature, absent in isotropic models, is an extra non-holonomic constraint, which survives the deparameterization and constrains the range of physical variables. The appearance of the constraint reflects the `amplification' of singularity due to anisotropy. The quantization smoothes the extra constraint and allows quantum contracting trajectories to be smoothly transformed into expanding ones. Making use of affine coherent state we develop a semiclassical description. Figures are included to illustrate our result.
description: 21 pages, 4 figures
Cosmic Expansion in Extended Quasidilaton Massive Gravity
Creators: name: Kahniashvili, Tina
name: Kar, Arjun
name: Lavrelashvili, George
name: Agarwal, Nishant
name: Heisenberg, Lavinia
name: Kosowsky, Arthur
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Quasidilaton massive gravity offers a physically well-defined gravitational theory with non-zero graviton mass. We present the full set of dynamical equations governing the expansion history of the universe, valid during radiation domination, matter domination, and a late-time self-accelerating epoch related to the graviton mass. The existence of self-consistent solutions constrains the amplitude of the quasi-dilaton field and the graviton mass, as well as other model parameters. We point out that the effective mass of gravitational waves can be significantly larger than the graviton mass, opening the possibility that a single theory can explain both the late-time acceleration of the cosmic expansion and modifications of structure growth leading to the suppression of large-angle correlations observed in the cosmic microwave background.
description: 5 pages, 1 figure; eq. 7 corrected - conclusions have not changed
A cellular genetics approach identifies gene-drug interactions and pinpoints drug toxicity pathway nodes
Creators: name: Suzuki, Oscar T.
name: Healy, Eric
name: McQuaid, Patricia E.
name: Chan, Emmanuel
name: Scoville, David K.
name: Benton, Cristina
name: Steffy, Brian
name: Wiltshire, Tim
name: Butz, Natasha
name: Parks, Bethany B.
name: Frick, Amber
name: Thomas, Russell S.
name: Trask, O. Joseph
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: New approaches to toxicity testing have incorporated high-throughput screening across a broad-range of in vitro assays to identify potential key events in response to chemical or drug treatment. To date, these approaches have primarily utilized repurposed drug discovery assays. In this study, we describe an approach that combines in vitro screening with genetic approaches for the experimental identification of genes and pathways involved in chemical or drug toxicity. Primary embryonic fibroblasts isolated from 32 genetically-characterized inbred mouse strains were treated in concentration-response format with 65 compounds, including pharmaceutical drugs, environmental chemicals, and compounds with known modes-of-action. Integrated cellular responses were measured at 24 and 72 h using high-content imaging and included cell loss, membrane permeability, mitochondrial function, and apoptosis. Genetic association analysis of cross-strain differences in the cellular responses resulted in a collection of candidate loci potentially underlying the variable strain response to each chemical. As a demonstration of the approach, one candidate gene involved in rotenone sensitivity, Cybb, was experimentally validated in vitro and in vivo. Pathway analysis on the combined list of candidate loci across all chemicals identified a number of over-connected nodes that may serve as core regulatory points in toxicity pathways.
“เพื่อความก้าวหน้าของประมงไทย...เพื่อชีวิตคือความมีเงิน”: การเปลี่ยนแปลงเทคโนโลยีประมงทะเลไทย พ.ศ. 2489 - 2503
Creators: name: นิภาพร รัชตพัฒนากุล
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2021
Subjects: ไทย
อุตสาหกรรมประมง
ระบบเทคโนโลยี
การถ่ายทอดเทคโนโลยี

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 21, 2, 30-57
Incorporating epigenetic data into the risk assessment process for the toxic metals arsenic, cadmium, chromium, lead, and mercury: strategies and challenges
Creators: name: Ray, Paul D.
name: Fry, Rebecca C.
name: Yosim, Andrew
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Exposure to toxic metals poses a serious human health hazard based on ubiquitous environmental presence, the extent of exposure, and the toxicity and disease states associated with exposure. This global health issue warrants accurate and reliable models derived from the risk assessment process to predict disease risk in populations. There has been considerable interest recently in the impact of environmental toxicants such as toxic metals on the epigenome. Epigenetic modifications are alterations to an individual's genome without a change in the DNA sequence, and include, but are not limited to, three commonly studied alterations: DNA methylation, histone modification, and non-coding RNA expression. Given the role of epigenetic alterations in regulating gene and thus protein expression, there is the potential for the integration of toxic metal-induced epigenetic alterations as informative factors in the risk assessment process. In the present review, epigenetic alterations induced by five high priority toxic metals/metalloids are prioritized for analysis and their possible inclusion into the risk assessment process is discussed.
ที่มาของพระประคนธรรพ
Creators: name: นาวิน โบษกรนัฏ
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2021
Subjects: คนธรรพ์
เทพปกรณัมฮินดู
พิธีไหว้ครูดนตรีไทย

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 21, 2, 58-79
On the processes generating latitudinal richness gradients: identifying diagnostic patterns and predictions
Creators: name: Hurlbert, Allen H.
name: Stegen, James C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: We use a simulation model to examine four of the most common hypotheses for the latitudinal richness gradient and identify patterns that might be diagnostic of those four hypotheses. The hypotheses examined include (1) tropical niche conservatism, or the idea that the tropics are more diverse because a tropical clade origin has allowed more time for diversification in the tropics and has resulted in few species adapted to extra-tropical climates. (2) The ecological limits hypothesis suggests that species richness is limited by the amount of biologically available energy in a region. (3) The speciation rates hypothesis suggests that the latitudinal gradient arises from a gradient in speciation rates. (4) Finally, the tropical stability hypothesis argues that climatic fluctuations and glacial cycles in extratropical regions have led to greater extinction rates and less opportunity for specialization relative to the tropics. We found that tropical niche conservatism can be distinguished from the other three scenarios by phylogenies which are more balanced than expected, no relationship between mean root distance (MRD) and richness across regions, and a homogeneous rate of speciation across clades and through time. The energy gradient, speciation gradient, and disturbance gradient scenarios all produced phylogenies which were more imbalanced than expected, showed a negative relationship between MRD and richness, and diversity-dependence of speciation rate estimates through time. We found that the relationship between speciation rates and latitude could distinguish among these three scenarios, with no relation expected under the ecological limits hypothesis, a negative relationship expected under the speciation rates hypothesis, and a positive relationship expected under the tropical stability hypothesis. We emphasize the importance of considering multiple hypotheses and focusing on diagnostic predictions instead of predictions that are consistent with multiple hypotheses.
Replication of obesity and diabetes-related SNP associations in individuals from Yucatán, México
Creators: name: Bastarrachea, Raul A.
name: Hernandez-Escalante, Victor M.
name: Kent, Jack W.
name: Comuzzie, Anthony G.
name: Voruganti, V. Saroja
name: Laviada-Molina, Hugo A.
name: Gallegos-Cabriales, Esther C.
name: Molina-Segui, Fernanda
name: Mezzles, Marguerite J.
name: Cole, Shelley A.
name: Nava-Gonzalez, Edna J.
name: Haack, Karin
name: Lopez-Alvarenga, Juan Carlos
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The prevalence of type 2 diabetes (T2D) is rising rapidly and in Mexicans is ~19%. T2D is affected by both environmental and genetic factors. Although specific genes have been implicated in T2D risk few of these findings are confirmed in studies of Mexican subjects. Our aim was to replicate associations of 39 single nucleotide polymorphisms (SNPs) from 10 genes with T2D-related phenotypes in a community-based Mexican cohort. Unrelated individuals (n = 259) living in southeastern Mexico were enrolled in the study based at the University of Yucatan School of Medicine in Merida. Phenotypes measured included anthropometric measurements, circulating levels of adipose tissue endocrine factors (leptin, adiponectin, pro-inflammatory cytokines), and insulin, glucose, and blood pressure. Association analyses were conducted by measured genotype analysis implemented in SOLAR, adapted for unrelated individuals. SNP Minor allele frequencies ranged from 2.2 to 48.6%. Nominal associations were found for CNR1, SLC30A8, GCK, and PCSK1 SNPs with systolic blood pressure, insulin and glucose, and for CNR1, SLC30A8, KCNJ11, and PCSK1 SNPs with adiponectin and leptin (p < 0.05). P-values greater than 0.0014 were considered significant. Association of SNPs rs10485170 of CNR1 and rs5215 of KCNJ11 with adiponectin and leptin, respectively, reached near significance (p = 0.002). Significant association (p = 0.001) was observed between plasma leptin and rs5219 of KCNJ11.
พุทธศาสนากับการสังเคราะห์ตนเข้ากับพหุวัฒนธรรมในสังคมจีน ช่วงคริสต์ศตวรรษที่ 3-6
Creators: name: ปกรณ์ ลิมปนุสรณ์
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2021
Subjects: พุทธศาสนาในจีน
หมิงเจี้ยว
เสวียนเสวีย
ศาสนาเต๋า

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 21, 2, 80-116
La science pour renforcer les plaidoyers des organismes de la société civile
Creators: name: Hot, Aurélie
name: Dagenais, Christian
name: Bekelynck, Anne
Publisher: name: Revue francophone de recherche sur le transfert et l’utilisation des connaissances
Year: 2023

description: S’il existe de nombreuses définitions du terme plaidoyer, certaines prennent en compte explicitement l’apport des connaissances scientifiques, alors que la plupart n’en font pas mention. Alors quelle est la place des connaissances scientifiques dans une stratégie de plaidoyer ? Pourquoi, et surtout comment, appuyer les organismes de la société civile dans ce domaine ? L’inspiration pour cet éditorial provient d’une expérience de formation au plaidoyer scientifique offerte à la coalition des organismes de lutte contre le cancer du col en Côte d’Ivoire (COL-CC). Nous revenons d’abord sur différentes acceptions de ce terme. Nous réitérons ensuite, en présentant brièvement cette expérience concrète de formation, l’importance de créer un espace de délibération sur les connaissances scientifiques avec les organismes de la société civile. Multiplier les occasions de formation en plaidoyer scientifique constitue un levier pour que les OSC remplissent leur rôle légitime dans des changements de pratiques et de politiques complexes.
description: Revue francophone de recherche sur le transfert et l’utilisation des connaissances , Vol. 7 No 2 (2023): Volume 7 - Numéro 2
Addressing Bias in Small RNA Library Preparation for Sequencing: A New Protocol Recovers MicroRNAs that Evade Capture by Current Methods
Creators: name: Sison, Christina
name: Chines, Peter S.
name: Sethupathy, Praveen
name: Baran-Gale, Jeanette
name: Erdos, Michael R.
name: Kurtz, C. Lisa
name: Young, Alice
name: Fannin, Emily E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Recent advances in sequencing technology have helped unveil the unexpected complexity and diversity of small RNAs. A critical step in small RNA library preparation for sequencing is the ligation of adapter sequences to both the 5′ and 3′ ends of small RNAs. Studies have shown that adapter ligation introduces a significant but widely unappreciated bias in the results of high-throughput small RNA sequencing. We show that due to this bias the two widely used Illumina library preparation protocols produce strikingly different microRNA (miRNA) expression profiles in the same batch of cells. There are 102 highly expressed miRNAs that are >5-fold differentially detected and some miRNAs, such as miR-24-3p, are over 30-fold differentially detected. While some level of bias in library preparation is not surprising, the apparent massive differential bias between these two widely used adapter sets is not well appreciated. In an attempt to mitigate this bias, the new Bioo Scientific NEXTflex V2 protocol utilizes a pool of adapters with random nucleotides at the ligation boundary. We show that this protocol is able to detect robustly several miRNAs that evade capture by the Illumina-based methods. While these analyses do not indicate a definitive gold standard for small RNA library preparation, the results of the NEXTflex protocol do correlate best with RT-qPCR. As increasingly more laboratories seek to study small RNAs, researchers should be aware of the extent to which the results may differ with different protocols, and should make an informed decision about the protocol that best fits their study.
Genetics of kidney disease and related cardiometabolic phenotypes in Zuni Indians: the Zuni Kidney Project
Creators: name: Zager, Philip G.
name: Voruganti, V. Saroja
name: Cole, Shelley A.
name: MacCluer, Jean W.
name: Tentori, Francesca
name: Haack, Karin
name: Shah, Vallabh O.
name: Bobelu, Arlene
name: Paine, Susan S.
name: Comuzzie, Anthony G.
name: Ghahate, Donica
name: Bobelu, Jeanette
name: Laston, Sandra L.
name: Harford, Antonia M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The objective of this study is to identify genetic factors associated with chronic kidney disease (CKD) and related cardiometabolic phenotypes among participants of the Genetics of Kidney Disease in Zuni Indians study. The study was conducted as a community-based participatory research project in the Zuni Indians, a small endogamous tribe in rural New Mexico. We recruited 998 members from 28 extended multigenerational families, ascertained through probands with CKD who had at least one sibling with CKD. We used the Illumina Infinium Human1M-Duo version 3.0 BeadChips to type 1.1 million single nucleotide polymorphisms (SNPs). Prevalence estimates for CKD, hyperuricemia, diabetes, and hypertension were 24%, 30%, 17% and 34%, respectively. We found a significant (p < 1.58 × 10-7) association for a SNP in a novel gene for serum creatinine (PTPLAD2). We replicated significant associations for genes with serum uric acid (SLC2A9), triglyceride levels (APOA1, BUD13, ZNF259), and total cholesterol (PVRL2). We found novel suggestive associations (p < 1.58 × 10-6) for SNPs in genes with systolic (OLFML2B), and diastolic blood pressure (NFIA). We identified a series of genes associated with CKD and related cardiometabolic phenotypes among Zuni Indians, a population with a high prevalence of kidney disease. Illuminating genetic variations that modulate the risk for these disorders may ultimately provide a basis for novel preventive strategies and therapeutic interventions.
Synthesis and antibacterial activity in vitro of 2-benzylthioimidazo[1,2-a]pyridine derivatives against pathogenic bacterial
Creators: name: Ablo, Evrard
name: Coulibali, Siomenan
name: Touré, Daouda
name: Coulibaly, Souleymane
name: Kablan, Ahmont Landry Claude
name: Kouadio, Fernique Konan
name: Sissouma, Drissa
name: Kouadio, Nathalie Guessend
name: Ané, Adjou
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: To explore the antibacterial activity, a set of new 2-thiobenzyl-3-nitro-imidazo[1,2-a]pyridine derivatives were synthesized (9a–h) and characterized by NMR 1H, 13C and high-resolution mass (HRMS). These compounds were obtained by interaction between the 3-nitro-imidazo[1,2-a]pyridine isothiouronium salt (7) with benzyl chloride or bromide (8) in the presence of sodium hydroxide (NaOH). Eight (9a–h) of them were evaluated in vitro on the positive gram bacterium (S. aureus ATCC 29213) and two others negative gram bacteria (P. aeruginosa ATCC 27853 and P. aeruginosa 933 C/21) by methods diffusion in solid medium and liquid macrodilution. Five among the eight compounds (9a, 9d, 9h, 9f and 9g) showed significant antibacterial activity on P. aeruginosa ATCC 27853 and P. aeruginosa 933 C/21with MIC between 7.81 and 250 µg/mL. All compounds were inactive on S. aureus. The compounds 9a and 9g were more potent on the two strains of P. aeruginosa ATCC 27853.
Learning about the X from our parents
Creators: name: Wise, Alison S.
name: Weinberg, Clarice R.
name: Shi, Min
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The X chromosome is generally understudied in association studies, in part because the analyst has had limited methodological options. For nuclear-family-based association studies, most current methods extend the transmission disequilibrium test (TDT) to the X chromosome. We present a new method to study association in case-parent triads: the parent-informed likelihood ratio test for the X chromosome (PIX-LRT). Our method enables estimation of relative risks and takes advantage of parental genotype information and the sex of the affected offspring to increase statistical power to detect an effect. Under a parental exchangeability assumption for the X, if case-parent triads are complete, the parents of affected offspring provide an independent replication sample for estimates based on transmission distortion to their affected offspring. For each offspring sex we combine the parent-level and the offspring-level information to form a likelihood ratio test statistic; we then combine the two to form a combined test statistic. Our method can estimate relative risks under different modes of inheritance or a more general co-dominant model. In triads with missing parental genotypes, the method accounts for missingness with the Expectation-Maximization algorithm. We calculate non-centrality parameters to assess the power gain and robustness of our method compared to alternative methods. We apply PIX-LRT to publically available data from an international consortium of genotyped families affected by the birth defect oral cleft and find a strong, internally-replicated signal for a SNP marker related to cleft lip with or without cleft palate.
Mechanisms for Phase Shifting in Cortical Networks and their Role in Communication through Coherence
Creators: name: Tiesinga, Paul H.
name: Sejnowski, Terrence J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: In the primate visual cortex, the phase of spikes relative to oscillations in the local field potential (LFP) in the gamma frequency range (30–80 Hz) can be shifted by stimulus features such as orientation and thus the phase may carry information about stimulus identity. According to the principle of communication through coherence (CTC), the relative LFP phase between the LFPs in the sending and receiving circuits affects the effectiveness of the transmission. CTC predicts that phase shifting can be used for stimulus selection. We review and investigate phase shifting in models of periodically driven single neurons and compare it with phase shifting in models of cortical networks. In a single neuron, as the driving current is increased, the spike phase varies systematically while the firing rate remains constant. In a network model of reciprocally connected excitatory (E) and inhibitory (I) cells phase shifting occurs in response to both injection of constant depolarizing currents and to brief pulses to I cells. These simple models provide an account for phase-shifting observed experimentally and suggest a mechanism for implementing CTC. We discuss how this hypothesis can be tested experimentally using optogenetic techniques.
Rational design of transcranial current stimulation (TCS) through mechanistic insights into cortical network dynamics
Creators: name: Fröhlich, Flavio
name: Schmidt, Stephen L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Transcranial current stimulation (TCS) is a promising method of non-invasive brain stimulation to modulate cortical network dynamics. Preliminary studies have demonstrated the ability of TCS to enhance cognition and reduce symptoms in both neurological and psychiatric illnesses. Despite the encouraging results of these studies, the mechanisms by which TCS and endogenous network dynamics interact remain poorly understood. Here, we propose that the development of the next generation of TCS paradigms with increased efficacy requires such mechanistic understanding of how weak electric fields (EFs) imposed by TCS interact with the nonlinear dynamics of large-scale cortical networks. We highlight key recent advances in the study of the interaction dynamics between TCS and cortical network activity. In particular, we illustrate an interdisciplinary approach that bridges neurobiology and electrical engineering. We discuss the use of (1) hybrid biological-electronic experimental approaches to disentangle feedback interactions; (2) large-scale computer simulations for the study of weak global perturbations imposed by TCS; and (3) optogenetic manipulations informed by dynamic systems theory to probe network dynamics. Together, we here provide the foundation for the use of rational design for the development of the next generation of TCS neurotherapeutics.
Dimroth rearrangement to 2-N-alkylated amino pyridines: an unusual reaction of primary amines with ylidineketonitriles
Creators: name: Karuturi, Damodar
name: Kalbagh, Mahesh
name: Kamath, Prashantha
name: Montgomery, Mark
name: Shete, Shrikant Abhiman
name: Lal, Mukul
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Inorganic Chemistry
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Unusual reaction of Ylideneketonitrile with primary amine led to the formation of 2-N-alkylated-3,5-trisubstituted pyridines. Mechanistic aspect of the reaction path was mapped by isolation and characterization of crucial intermediates of the reaction. Dimroth rearrangement was key to the formation of diverse pyridine derivatives in good to excellent yield (50 − 90%).
“พุทธ” “เต๋า” “ขงจื่อ” เสมือนหนึ่งเดียว? ใน “ห้องสิน” วรรณกรรมเอกสมัยราชวงศ์หมิง
Creators: name: บุรินทร์ ศรีสมถวิล
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2021
Subjects: ห้องสิน
คติพุทธ
เต๋า
ขงจื่อ
กระบวนการประสมประสาน
กลมกลืน

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 21, 2, 117-156
การปะทะสังสรรค์ของคติขงจื๊อ เต๋า พุทธในตัวละครหงอคงในวรรณกรรมไซอิ๋ว
Creators: name: สุรสิทธิ์ อมรวณิชศักดิ์
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2021
Subjects: หงอคง
ไซอิ๋ว
พุทธ
เต๋า
ขงจื๊อ
การปะทะสังสรรค์

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 21, 2, 157-189
Ancient evolutionary origins of epigenetic regulation associated with posttraumatic stress disorder
Creators: name: Galea, Sandro
name: Hou, Zhou-Cheng
name: Sipahi, Levent
name: Uddin, Monica
name: Koenen, Karestan C.
name: Aiello, Allison E.
name: Wildman, Derek E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Epigenetic marks, including DNA methylation, are modifiable molecular factors that may underlie mental disorders, especially responses to trauma, including the development of and resilience to posttraumatic stress disorder (PTSD). Previous work has identified differential DNA methylation at CpG dinucleotide sites genomewide between trauma exposed individuals with and without PTSD, suggesting a role for epigenetic potential—the capacity to epigenetically regulate behavior and physiology in response to lived experiences. The human species is characterized by an increased period of adaptive plasticity during brain development. The evolutionary history of epigenetic potential in relation to adaptive plasticity is currently unknown. Using phylogenetic methods and functional annotation analyses, we trace the evolution of over 7000 CpG dinucleotides, including 203 associated with PTSD, during the descent of humans in during mammalian evolution and characterize the biological significance of this evolution. We demonstrate that few (7%) PTSD-associated CpG sites are unique to humans, while the vast majority of sites have deep evolutionary origins: 73 and 93% were unambiguously present in the last common ancestor of humans/orangutans and humans/chimpanzees, respectively. Genes proximal to evolved PTSD-associated CpG sites revealed significant enrichment for immune function during recent human evolution and regulation of gene expression during more ancient periods of human evolution. Additionally, 765 putative transcription factor binding motifs (TFBMs) were identified that overlap with PTSD-associated CpG sites. Elucidation of the evolutionary history of PTSD-associated CpG sites may provide insights into the function and origin of epigenetic potential in trauma responses, generally, and PTSD, specifically. The human capacity to respond to trauma with stable physiologic and behavioral changes may be due to epigenetic potentials that are shared among many mammalian species.