cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Flavobacterium psychrophilum Infections in Salmonid Broodstock and Hatchery-Propagated Stocks of the Great Lakes Basin
Creators: name: Vliet, Danielle Van
name: Loch, Thomas P.
name: Faisal, Mohamed
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Microbiology

description: Bacterial coldwater disease (BCWD), caused by Flavobacterium psychrophilum, threatens wild and propagated salmonids worldwide and leads to substantial economic losses. In addition to being horizontally transmitted, F. psychrophilum can be passed from infected parents to their progeny, furthering the negative impacts of this pathogen. In Michigan, both feral and captive salmonid broodstocks are the gamete sources used in fishery propagation efforts. A 5-year study was initiated to follow the prevalence of systemic F. psychrophilum infections in feral broodstocks of four species (steelhead Oncorhynchus mykiss [potadromous Rainbow Trout]; Coho Salmon O. kisutch; Chinook Salmon O. tshawytscha; and Atlantic Salmon Salmo salar) residing in three Great Lakes watersheds. Additionally, captive broodstocks of four species (Rainbow Trout, Brown Trout Salmo trutta, Lake Trout Salvelinus namaycush, and Brook Trout Salvelinus fontinalis) maintained at two facilities were assessed for the presence of F. psychrophilum. The resultant offspring from each broodstock population were sampled for F. psychrophilum infections multiple times throughout hatchery residency. Using selective flavobacterial culture and PCR confirmation, F. psychrophilum was detected in all broodstocks except the captive Lake Trout and Brook Trout. Logistic regression analysis demonstrated that among the infected feral broodstocks, Chinook Salmon from the Lake Michigan watershed had the highest prevalence of systemic F. psychrophilum infection (mean = 63.2%). Among the captive broodstocks, the Gilchrist Creek strain of Brown Trout had the highest infection prevalence (mean = 5%). Collectively, the captive broodstocks were found to have significantly lower infection prevalence than the feral broodstocks. Despite the high prevalence of systemic F. psychrophilum infections in many broodstock populations, the bacterium was rarely detected in their progeny during hatchery rearing. However, heavy losses associated with clinical BCWD outbreaks did occur. Collectively, our results reinforce that BCWD continues to threaten Great Lakes basin salmonids.Received April 6, 2015; accepted August 25, 2015
Quantification of Dry Matter Accumulation and Nutrient Uptake Pattern of Short Day Onion (Allium cepa L.)
Creators: name: Arunachalam Thangasamy
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: Earth and Environmental Sciences
subject: Pharmacology
subject: Cell Biology
subject: Medicine

description: Understanding the physiology of dry matter accumulation and nutrient uptake pattern of an onion crop is an essential criteria for optimizing fertilizer practices. An experiment was conducted to estimate the dry matter accumulation and nutrient uptake pattern of short day onion. The dry matter accumulation and nutrient uptake followed the sigmoid growth curve pattern. Nitrogen and potassium uptake was slow up to first 15 days followed by rapid uptake from 15 to 60 days after transplanting and accounted for 76.2–78.2% of total uptake. Whereas, phosphorus, sulfur, manganese, zinc and copper uptake were higher during 30 to 75 days after transplanting and accounted for 64.9–70.6% of total uptake. The deficiency of nutrients during these period reduces the crop yield significantly. The dry matter accumulation and nutrient uptake pattern reported in this study likely to provide an opportunity for optimizing quantity and timing of nutrient application through fertilizers for short day onions.
title: Les parlers du Croissant: Marcenat: Lexique fondamental - Divers
Creators: name: Deparis, Amélie
name: Guérin, Maximilien
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2025
Subjects: subject: Marcenatois
subject: oci

description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
title: Les parlers du Croissant: Marcenat: Lexique fondamental - Pronoms
Creators: name: Deparis, Amélie
name: Guérin, Maximilien
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2025
Subjects: subject: Marcenatois
subject: oci

description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
The Reciprocity Controversy
Creators: name: Carter, Gerald
Publisher: name: figshare
Year: 2015
Subjects: subject: Zoology
subject: FOS: Biological sciences
subject: Evolutionary Biology

description: This paper was originally published as Carter, G. 2014. The reciprocity controversy. Animal Behavior and Cognition. 1(3), 368-386. doi:10.12966/abc.08.11.2014
title: Философия
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2022

description: В учебнике представлена система философского знания, позволяющая студентам проникнуть в глубины духовного мира и приобрести компетенции, способствующие успешному решению профессиональных задач. В нём развёрнута система «мир ↔ человек», отражены концепции известных философов и философских школ, философские новеллы, способствующие формированию мировоззренческой культуры, диалектического мышления. Материал учебника отличается утончённостью изложения, энциклопедичностью, персонифицированностью. Он направлен на раскрытие творческого потенциала студентов, их духовное становление в динамично развивающемся высокотехнологичном обществе, в котором существенную роль играют информационно-коммуникационные технологии. Учебник подготовлен с учётом требований Федерального государственного образовательного стандарта высшего образования. Предназначен для студентов направления подготовки 47.03.01 «Философия», акцентирован на студентов естественно-научных и технических специальностей, изучающих дисциплину «Философия». Будет полезен всем, у кого существует потребность в системном философском знании.
title: Les parlers du Croissant: Marcenat: Conjugaison
Creators: name: Deparis, Amélie
name: Guérin, Maximilien
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2025
Subjects: subject: Marcenatois
subject: oci

description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
Large geometric polarization and magnetic behavior in the multiferroic quasi-2D SrNiF$_4$ fluoride
Creators: name: Ibarra-Hernández, W.
name: Bautista-Hernández, A.
name: Garcia-Castro, A. C.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: In the last decades, multifunctional single-crystals that show, for example, multiferroic and magnetoelectric responses have attracted considerable attention due to the potential applications and physical phenomena involved in the entanglement of the ferroic orders. This paper investigates the structural, ferroelectric, and magnetic properties of the unexplored layered SrNiF$_4$ fluoride compound. We show that, in terms of the vibrational phonon modes, this fluoride compound shows a tangible ferroelectric behavior with a spontaneous polarization as large as $P_s$ = 14.8 $μ$C$\cdot$cm$^{-2}$ standing as one of the largest among its family. Besides, based on our findings such ferroelectric polarization presents a geometric origin that is strongly entangled with the octahedral rotations within the $Γ_2^-$ phonon mode and enhanced by the structure's $Γ_1^+$ mode. We also observed that the spontaneous polarization is coupled to the noncollinear $G$-type antiferromagnetic ordering in the structure allowing a switching of the weak antiferromagnetic component when the polarization is reversed.
Phase dynamics of tunnel Al-based ferromagnetic Josephson junctions
Creators: name: Ahmad, Halima Giovanna
name: Satariano, Roberta
name: Ferraiuolo, Raffaella
name: Vettoliere, Antonio
name: Granata, Carmine
name: Montemurro, Domenico
name: Ausanio, Giovanni
name: Parlato, Loredana
name: Pepe, Giovanni Piero
name: Tafuri, Francesco
name: Massarotti, Davide
Publisher: name: arXiv
Year: 2024
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: By measuring the current-voltage characteristics and the switching current distributions as a function of temperature, we have investigated the phase dynamics of Al tunnel ferromagnetic Josephson junctions (JJs), designed to fall in the typical range of parameters of state-of-the-art transmons, providing evidence of phase diffusion processes. The comparison with the experimental outcomes on non-magnetic JJs with nominally the same electrodynamical parameters demonstrates that the introduction of ferromagnetic barriers does not cause any sizeable detrimental effect, and supports the notion of including tunnel ferromagnetic JJs in qubit architectures.
description: Accepted Manuscript Version. Please cite this article as DOI: 10.1063/5.0211006
Oscillatory responses to reward processing in borderline personality disorder
Creators: name: Andreou, Christina
name: Leicht, Gregor
name: Mulert, Christoph
name: Kleinert, Julia
name: Steinmann, Saskia
name: Fuger, Ulrike
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Science Policy
subject: Cancer
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Earth and Environmental Sciences
subject: Genetics
subject: FOS: Biological sciences

description: Objectives. Previous electrophysiological studies have confirmed impaired reward processing in patients with BPD. However, it is not clear which aspects of reward processing are affected and which brain regions are involved. The present study investigated both evoked and induced event-related oscillations (EROs) to feedback events (thought to represent different aspects of feedback processing), and used source localization (sLORETA) to assess activity in two areas known to contribute to reward processing, the dorsomedial prefrontal/anterior cingulate cortex (dmPFC/ACC) and the orbitofrontal cortex (OFC). Methods. Eighteen patients with BPD and 22 healthy controls performed a gambling task, while 64-channel electroencephalographic activity was recorded. Evoked and induced theta and high-beta band EROs as well as activity in the two regions of interest were investigated depending on the valence and magnitude of feedback events. Results. Theta-band responses to negative feedback were reduced in BPD, an effect that involved only evoked responses and the dmPFC/ ACC region, and was associated with trait impulsivity in patients. sLORETA analyses revealed disturbed evoked responses depending on feedback magnitude in the theta (OFC) and high-beta (dmPFC/ACC and OFC) frequency range. Conclusions. The results indicate multiple dysfunctions of feedback processing in patients with BPD, implicating several distinct subsets of reward-processing mechanisms.
Relación para alabar a los novios en cualquier boda: Digital edition
Creators: name: Betti Miguel
name: Leblanc Elina
Publisher: name: Zenodo
Year: 2024
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2024), led by professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Identification and functional characterisation of a novel dopamine beta hydroxylase gene variant associated with attention deficit hyperactivity disorder
Creators: name: Tong, Janette
name: Cummins, Tarrant D.R.
name: Matthews, Natasha
name: Vance, Alasdair
name: Gill, Michael
name: Kent, Lindsey
name: Bellgrove, Mark A.
name: Ziarih Hawi
name: Leigh-Anne McKinley
name: Johnson, Beth
name: Heussler, Helen
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Cancer
subject: Biological Sciences
subject: Physiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Molecular Biology
subject: Genetics
subject: Medicine

description: Objectives. Dysregulation in neurotransmitter signalling has been implicated in the aetiology of attention deficit hyperactivity disorder (ADHD). Polymorphisms of the gene encoding dopamine beta hydroxylase (DBH) have been reported to be associated with ADHD; however, small sample sizes have led to inconsistency. Methods. We conducted transmission disequilibrium test analysis in 794 nuclear families to examine the relationship between DBH and ADHD. The effects of the ADHD-associated polymorphisms on gene expression were assessed by luciferase reporter assays in a human neuroblastoma cell line, SH-SY5Y. Results. A SNP within the 3′ untranslated region of DBH rs129882 showed a significant association with ADHD (χ2 = 9.71, p = 0.0018, OR = 1.37). This association remained significant after Bonferroni correction for multiple testing (p = 0.02). Further, allelic variation in rs129882 significantly impacted luciferase expression. Specifically, the C allele of the ADHD-associated rs129882 SNP produced a 2-fold decrease (p < 0.001) in luciferase activity. Conclusions. These data demonstrate for the first time that a DBH gene variant, rs129882, which confers risk to ADHD is also associated with reduced in vitro gene expression. Reduced DBH expression would be consistent with decreased conversion of dopamine to noradrenaline and thus with a relative hypo-noradrenergic state in ADHD.
Suicidal behaviour and memory: A systematic review and meta-analysis
Creators: name: Berlim, Marcelo T.
name: Stephane Richard-Devantoy
name: Jollant, Fabrice
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Neuroscience

description: Objectives. Suicidal behaviour results from a complex interplay between stressful events and vulnerability factors, including cognitive deficits. It is not yet clear if memory impairment is part of this specific vulnerability. Therefore, the objective of this study was to examine the association between memory deficits and vulnerability to suicidal acts. Methods. A literature review was performed using Medline, Embase, and PsycInfo databases. Twenty-four studies (including 2,595 participants) met the selection criteria. Four different types of memory (i.e., working memory, short- and long-term memory, and autobiographical memory) were assessed in at least three different studies. Results. Autobiographical memory was significantly less specific and more general in patients with a history of suicide attempt relative to those without such a history (Hedges’ g = 0.8 and 0.9, respectively). Long-term memory and working memory were both more impaired in suicide attempters than in patient and healthy controls. Only short-term memory did not differentiate suicide attempters from patient controls. Conclusions. Memory may play a significant role in the risk of suicidal acts, perhaps by preventing these individuals from using past experiences to solve current problems and to envision the future, and by altering inhibitory processes. More studies are necessary to better clarify these relationships.
Relación para alabar a los novios en cualquier boda: Digital edition
Creators: name: Miguel, Betti
name: Leblanc Elina
Publisher: name: Zenodo
Year: 2021
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2022), led by the professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Enhanced Model-Free Dynamic State Estimation for a Soft Robot Finger Using an Embedded Optical Waveguide Sensor
Creators: name: Krauss, Henrik
name: Takemura, Kenjiro
Publisher: name: arXiv
Year: 2024
Subjects: subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: In this letter, an advanced stretchable optical waveguide sensor is implemented into a multidirectional PneuNet soft actuator to enhance dynamic state estimation through a NARX neural network. The stretchable waveguide featuring a semidivided core design from previous work is sensitive to multiple strain modes. It is integrated into a soft finger actuator with two pressure chambers that replicates human finger motions. The soft finger, designed for applications in soft robotic grippers or hands, is viewed in isolation under pneumatic actuation controlled by motorized linear stages. The research first characterizes the soft finger's workspace and sensor response. Subsequently, three dynamic state estimators are developed using NARX architecture, differing in the degree of incorporating the optical waveguide sensor response. Evaluation on a testing path reveals that the full sensor response significantly improves end effector position estimation, reducing mean error by 51\% from 5.70 mm to 2.80 mm, compared to only 21\% improvement to 4.53 mm using the estimator representing a single core waveguide design. The letter concludes by discussing the application of these estimators for (open-loop) model-predictive control and recommends future focus on advanced, structured soft (optical) sensors for model-free state estimation and control of soft robots.
description: Accepted for publication in IEEE Robotics and Automation Letters (RA-L) 2024
Relación para alabar a los novios en cualquier boda: Digital edition
Creators: name: Betti Miguel
name: Leblanc Elina
Publisher: name: Zenodo
Year: 2022
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2024), led by the professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Relationships of local lithium concentrations in drinking water to regional suicide rates in Italy
Creators: name: Dinelli, Enrico
name: Valera, Paolo
name: Fiorillo, Andrea
name: Amore, Mario
name: Girardi, Paolo
name: Baldessarini, Ross J.
name: Pompili, Maurizio
name: Vichi, Monica
name: Pycha, Roger
name: Albanese, Stefano
name: Lima, Annamaria
name: Vivo, Benedetto De
name: Cicchella, Domenico
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Earth and Environmental Sciences
Biophysics

description: Objectives. Higher natural concentrations of lithium in drinking water may be associated with lower local rates of suicide. Methods. Lithium concentrations in drinking water were assayed by mass spectrometry at 145 sites in Italy, and compared with reported local suicide rates for men and women between 1980 and 2011. Results. Lithium concentrations in drinking water averaged 5.28 [CI: 4.08–6.48] μg/L (0.761 [0.588–0.934] μEq/L) and ranged from 0.110 to 60.8 μg/L (1.58 to 8.76 μEq/L). Lithium concentrations and local suicide rates were not significantly inversely related, except in 1980–1989, particularly among women. Conclusions. A proposed association between trace lithium concentrations in drinking water and risk of suicide was only partially supported, and mechanisms for potential clinical effects of trace levels of lithium are unknown.
title: Understanding the College Experience of Students with Functional Gastrointestinal Disorders
Creators: name: Andrews, Molly Kiley
Publisher: name: University of Massachusetts Amherst
Year: 2024

description: Studies have shown undergraduate students with a functional gastrointestinal disorder (FGID) such as irritable
bowel syndrome (IBS), gastroesophageal reflux disease (GERD), functional dysplasia (FD), or other related
functional gastrointestinal disorders have a greater level of perceived stress and a greater difficulty during the
transition to college than their healthy peers. There is limited research on how undergraduate students with
FGIDs conceptualize their disease, cope mentally and physically, and manage symptoms during the college
experience. Because diet is essential in FGID symptom management, the current study aims to understand how
on-campus dining options impact the mental and physical health of students with FGIDs and how social,
emotional, and personal environments impact their disease management. For many first and multi-year
undergraduates, attending post-secondary education includes a dining plan managed and provided by the college
or university. Understanding how the foods and resources provided are inclusive to those with FGIDs could help
explore the importance of proper nutritional options and emotional support networks to provide insight into the
lived experience of undergraduates with FGIDs. This study utilized qualitative in-depth semistructured
interviews to better understand how functional gastrointestinal disorders shape the college social, personal, and
nutritional experience and to understand how on-campus dining services impact symptom and disease
management. The results may be valuable for campus administrators, health and dining service professionals,
and others who make decisions about campus resources and wellbeing.
Refactoring to Pythonic Idioms: A Hybrid Knowledge-Driven Approach Leveraging Large Language Models
Creators: name: Zhang, Zejun
name: Xing, Zhenchang
name: Ren, Xiaoxue
name: Lu, Qinghua
name: Xu, Xiwei
Publisher: name: arXiv
Year: 2024
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: Pythonic idioms are highly valued and widely used in the Python programming community. However, many Python users find it challenging to use Pythonic idioms. Adopting a rule-based approach or LLM-only approach is not sufficient to overcome three persistent challenges of code idiomatization including code miss, wrong detection and wrong refactoring. Motivated by the determinism of rules and adaptability of LLMs, we propose a hybrid approach consisting of three modules. We not only write prompts to instruct LLMs to complete tasks, but we also invoke Analytic Rule Interfaces (ARIs) to accomplish tasks. The ARIs are Python code generated by prompting LLMs to generate code. We first construct a knowledge module with three elements including ASTscenario, ASTcomponent and Condition, and prompt LLMs to generate Python code for incorporation into an ARI library for subsequent use. After that, for any syntax-error-free Python code, we invoke ARIs from the ARI library to extract ASTcomponent from the ASTscenario, and then filter out ASTcomponent that does not meet the condition. Finally, we design prompts to instruct LLMs to abstract and idiomatize code, and then invoke ARIs from the ARI library to rewrite non-idiomatic code into the idiomatic code. Next, we conduct a comprehensive evaluation of our approach, RIdiom, and Prompt-LLM on nine established Pythonic idioms in RIdiom. Our approach exhibits superior accuracy, F1-score, and recall, while maintaining precision levels comparable to RIdiom, all of which consistently exceed or come close to 90% for each metric of each idiom. Lastly, we extend our evaluation to encompass four new Pythonic idioms. Our approach consistently outperforms Prompt-LLM, achieving metrics with values consistently exceeding 90% for accuracy, F1-score, precision, and recall.
description: Accepted by FSE 2024,22 pages
Efficacy and tolerability of switching therapy to vortioxetine versus other antidepressants in patients with major depressive disorder
Creators: name: Brignone, Mélanie
name: Diamand, Françoise
name: Painchault, Caroline
name: Takyar, Shweta
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Science Policy
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biotechnology
subject: Pharmacology
subject: Medicine

description: Objectives: To assess relative efficacy and tolerability of vortioxetine against different antidepressant monotherapies in patients with major depressive disorder (MDD) with inadequate response to selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) therapy.Methods: A systematic search was conducted for monotherapy studies in patients with MDD with inadequate response to first-line therapy. Treatments included SSRIs, SNRIs, and other antidepressants. Identified studies underwent a three-stage screening/data extraction process and critical appraisal. Adjusted indirect treatment comparisons (ITC) on systematic literature review outputs were made using Bucher’s method, comparing remission rates and withdrawal rates due to adverse events (AEs).Results: Of 27 studies meeting the inclusion criteria, a few studies were of high quality according to the National Institute of Health and Care Excellence checklist. Three studies contributed to an evidence network for quantitative assessment comparing vortioxetine with agomelatine, sertraline, venlafaxine XR, and bupropion SR. Vortioxetine had a statistically significantly higher remission rate than agomelatine (risk difference [RD]: -11.0%, [95% CI: -19.4; -2.6]), and numerically higher remission rates than sertraline (RD: -14.4%, [95% CI: -29.9; 1.1]), venlafaxine (RD: -7.20%, [95% CI: -24.3; 9.9]), and bupropion (RD: -10.70%, [95% CI: -27.8; 6.4]). Withdrawal rates due to AEs were statistically significantly lower for vortioxetine than sertraline (RD: 12.1%, [95% CI: 3.1; 21.1]), venlafaxine XR (RD: 12.3%, [95% CI: 0.8; 23.8]), and bupropion SR (RD: 18.3%, [95% CI: 6.4; 30.1]).Conclusions: The current systematic literature review found a few high quality switch studies assessing monotherapies in patients with MDD with inadequate response to SSRI/SNRIs. ITCs indicated that switching to vortioxetine leads to numerically higher remission rates compared with other antidepressants. Vortioxetine is a well-tolerated treatment, showing statistically lower withdrawal rates due to AEs compared with other antidepressants. Vortioxetine is a relevant therapeutic alternative in patients experiencing inadequate response to prior SSRI or SNRI therapy.
title: Les parlers du Croissant: Naves: Lexique fondamental - Divers
Creators: name: Deparis, Amélie
name: Guérin, Maximilien
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2025
Subjects: subject: Navois
subject: oci

description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
Tube-enhanced multi-stage model predictive control for flexible robust control of constrained linear systems with additive and parametric uncertainties
Creators: name: Subramanian, Sankaranarayanan
name: Lucia, Sergio
name: Paulen, Radoslav
name: Engell, Sebastian
Publisher: name: TU Dortmund
Year: 2021
Subjects: subject: Constrained systems
subject: Predictive control
subject: Robust control
subject: Stability
subject: Uncertain systems
subject: 660

description: The trade-off between optimality and complexity has been one of the most important challenges in the field of robust model predictive control (MPC). To address the challenge, we propose a flexible robust MPC scheme by synergizing the multi-stage and tube-based MPC approaches. The key idea is to exploit the nonconservatism of the multi-stage MPC and the simplicity of the tube-based MPC. The proposed scheme provides two options for the user to determine the trade-off depending on the application: the choice of the robust horizon and the classification of the uncertainties. Beyond the robust horizon, the branching of the scenario-tree employed in multi-stage MPC is avoided with the help of tubes. The growth of the problem size with respect to the number of uncertainties is reduced by handling small uncertainties via an invariant tube that can be computed offline. This results in linear growth of the problem size beyond the robust horizon and no growth of the problem size concerning small magnitude uncertainties. The proposed approach helps to achieve a desired trade-off between optimality and complexity compared to existing robust MPC approaches. We show that the proposed approach is robustly asymptotically stable. Its advantages are demonstrated for a CSTR example.
description: International journal of robust and nonlinear control;31(9)
Application of polyimide-based microfluidic devices on acid-catalyzed hydrolysis of dimethoxypropane
Creators: name: Bobers, Jens
name: Forys, Elisabeth
name: Oldach, Bastian
name: Kockmann, Norbert
Publisher: name: TU Dortmund
Year: 2021
Subjects: subject: Acid-catalyzed hydrolysis
subject: Microreactor
subject: Mixing
subject: Polyimide foil
subject: 660

description: Microfluidic devices intensify transport phenomena and can improve chemical processes. New manufacturing processes and materials are perpetually developed due to constantly growing interest in process intensification. In this contribution, the authors present the design and application of polyimide-foil-based microfluidic mixing devices manufactured by reactive ion etching. As appropriate model reaction system, acid-catalyzed 2,2-dimethoxypropane (DMP) hydrolysis was chosen and investigated in three different mixing structure with varying flow rate. Energy dissipation rates were calculated to estimate mixing performances. The results show good mixing quality for Reynolds numbers between 10 and 100 and similar mixing times scales for all investigated microstructured mixers.
description: Chemie - Ingenieur - Technik;93(5)
CFD modeling of reactor concepts to avoid carbon deposition in pyrolysis reactions
Creators: name: Becker, Tobias
name: Keuchel, Florian
name: Agar, David W.
Publisher: name: TU Dortmund
Year: 2021
Subjects: subject: Carbon deposition
subject: Hydrogen
subject: Methane pyrolysis
subject: Reactor modeling
subject: 660

description: Methane pyrolysis in an externally heated tubular reactor inevitably ends with clogging of the reactor. Thin molten metal wall films protect the walls from carbon depositions. A falling film reactor and a rotating film reactor are investigated by CFD simulation. The results show the considerable advantages of a rotating film reactor compared to the vertical film reactor. An alternative route for carbon production from methane is the implementation of an exothermic chlorination reaction. The tubular reactor concept involves the inflow of inert gas at the reactant inlet and through porous walls to ensure that the reaction takes place in the center, thus, largely reducing carbon deposits.
description: Chemie - Ingenieur - Technik;93(5)
Evaluation of a short-term topical interferon α-2b treatment for histologically proven melanoma and primary acquired melanosis with atypia
Creators: name: Garip, Aylin
name: Schaumberger, Markus M.
name: Wolf, Armin
name: Herold, Tina R.
name: Miller, Christina V.
name: Klingenstein, Annemarie
name: Schebitz-Walter, Kirsten
name: Hintschich, Christoph R.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Biotechnology
subject: Cell Biology
subject: Microbiology
subject: FOS: Biological sciences
subject: Medicine

description: ABSTRACTObjective: To evaluate the efficiency of series of 6-week treatments with brief intervals (6-week = 1 cycle) of topical Interferon α-2b (IFNα-2b) treatment in primary acquired melanosis (PAM) with atypia and melanoma of the conjunctiva.Patients and Methods: Five patients with biopsy-proven PAM with atypia and seven patients with melanoma of the conjunctiva, treated with topical IFNα-2b (1 million units/ml, 5 times daily), were included in the study. All patients had colour photographs and the tumour area was measured manually for each patient before and after treatment.Results: The median age of 12 patients at initiation of treatment was 61.5 years (range 39–75 years). The mean therapy duration was 2.4 cycles (range 1-6 cycle).Compared to pretreatment lesion dimension, the mean decrease in tumour size were after the first cycle 66% (range 18–98%; p = 0.004; n = 10 patients), after the second cycle 55% (range 10–100%; p = 0.016; n = 7 patients), and after the third cycle 74% (range 23–100%; n = 3 patients). In one patient 6 cycles of topical IFNα-2b were needed. The decrease in size was 22% after the 4th cycle, 34% after the 5th cycle, and 98% after the 6th cycle.Conclusion: Our clinical experience demonstrates promising results of topical IFNα-2b treatment for PAM with atypia and melanoma of the conjunctiva without any local or systemic side effects. However, future multicenter prospective studies are recommended to confirm the efficiency and safety of topical IFNα-2b treatment.
IN03180 Veherakama Rock Inscription
Creators: name: Paranavitana, S.
Publisher: name: Zenodo
Year: 2020
Subjects: IN03180
Epigraphia Zeylanica
Veherakama

description: IN03180 Veherakama Rock Inscription - Transcript and Translation Source: Paranavitana, S. (1934–41). ‘No. 17. Seven Sinhalese Inscriptions of the Seventh and Eighth Centuries,’ Epigraphia Zeylanica 4, pp. 142–143, no. 17, I.
title: Les parlers du Croissant: Naves: Lexique fondamental - Pronoms
Creators: name: Deparis, Amélie
name: Guérin, Maximilien
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2025
Subjects: subject: Navois
subject: oci

description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
title: Les parlers du Croissant: Naves: Lexique fondamental - Noms
Creators: name: Deparis, Amélie
name: Guérin, Maximilien
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2025
Subjects: subject: Navois
subject: oci

description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
New insights from domain-averaged Fermi holes and bond order analysis into the bonding conundrum in C2
Creators: name: Cooper, David L.
name: Ponec, Robert
name: Kohout, Miroslav
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Biochemistry
subject: Biophysics

description: ABSTRACTThe bonding in the ground state of C2 is examined using a combined approach based on the analysis of domain-averaged Fermi holes and of the contributions to covalent bond orders that can be associated with individual localised natural orbitals. The σ system in this molecule turns out to be particularly sensitive, evolving from a description that includes a fairly traditional shared electron pair σ bond, for a range of intermediate nuclear separations, to a somewhat different situation near equilibrium geometry, where non-classical repulsive interactions are particularly important. The various results provide further support for the view that the electronic structure of this molecule sufficiently exceeds the scope of traditional bonding paradigms that attempts to classify the bonding in terms of a classical bond multiplicity are highly questionable.
Measurement properties of a patient-reported outcome measure assessing psoriasis severity: The psoriasis symptoms and signs diary
Creators: name: Feldman, Steven R.
name: Chenglong Han
name: Mathias, Susan D.
name: Crosby, Ross D.
name: Colwell, Hilary H.
name: McQuarrie, Kelly
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Science Policy
subject: Developmental Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biotechnology
subject: Medicine
subject: Engineering

description: Background: Collecting reliable and valid symptom information from patients is critical for assessing psoriasis severity in clinical research. Objective: To evaluate measurement properties of a new patient-reported outcome (PRO), the Psoriasis Symptoms and Signs Diary (PSSD). Methods: One hundred six US patients with moderate-to-severe plaque psoriasis completed two versions of the PSSD [a 24-hour recall (PSSD-24h) and 7-day recall (PSSD-7d)] using a 0–10 numerical rating scale. Reliability (test-retest and internal consistency), validity (convergent, divergent and known-groups), responsiveness, and version equivalence were evaluated. Minimally important difference was estimated. Results: Based on exploratory factor analysis and clinical input, symptom, sign, and total severity scores were established. Internal consistency (Cronbach’s alpha ≥ 0.944) and test-retest reliability (intraclass correlation coefficients ≥ 0.824) were acceptable. Correlations with Dermatology Life Quality Index (DLQI) (0.489 to 0.644) indicated convergent validity, while low correlations (Limitations: PSSD responsiveness should be evaluated in patients receiving treatment. Conclusion: The PSSD is reliable and valid in measuring symptoms/signs of patients with moderate-to-severe plaque psoriasis.
Provision of harm reduction and drug treatment services in custodial settings – Findings from the European ACCESS study
Creators: name: Zurhold, Heike
name: Stöver, Heino
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Sociology
subject: FOS: Sociology
subject: Chemistry
subject: Biotechnology
subject: Pharmacology
subject: Medicine

description: Aims: The aim of the study was to survey the availability, coverage and quality of harm reduction and drug treatment services delivered to drug users in prisons across Europe. Methods: A survey was conducted between 2012 and 2013 among the 29 European countries. An electronic semistructured questionnaire was sent to the national institutions responsible for prison services, and 27 countries responded. In addition, good practice interventions for drug offenders have been collated by 15 national experts covering 15 European countries. The interventions were described and assessed as to their quality through using European monitoring centre for drugs and drug addiction (EMCDDA) standard tools for reporting and quality assessment. Findings: Drug treatment including detoxification and opioid substitution treatment (OST) is available in prisons of most European countries. However, OST is unavailable in five countries. Almost all countries provide prison-based harm reduction measures to prevent and treat infectious diseases among prisoners. Especially, testing and treatment for HIV and tuberculosis are provided, while other measures, such as the distribution of condoms or bleach, and especially needle and syringe programmes are still rare. Conclusions: Access to and coverage of OST in prisons is higher in countries with a long history of OST provision, while in countries that introduced OST more recently the scale of OST is usually lower. Access to hepatitis C treatment is often limited in prisons due to the lack of drug abstinence or a health insurance.
title: Les parlers du Croissant: Naves: Conjugaison
Creators: name: Deparis, Amélie
name: Guérin, Maximilien
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2025
Subjects: subject: Navois
subject: oci

description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
Comparison of methods to quantify histone H2AX phosphorylation and its usefulness for prediction of radiosensitivity
Creators: name: Joan-Francesc Barquinero
name: Barrios, Leonardo
name: Borràs, Mireia
name: Armengol, Gemma
name: Martí De Cabo
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Cancer
Biological Sciences
Cell Biology
Medicine

description: Purpose: The number of radio-induced double-strand breaks is correlated with the number of histone gamma-H2AX (γ-H2AX) foci. For this reason, foci quantification is a useful tool to measure radiation-induced DNA damage and the number of foci has been suggested as a predictive biomarker of radiosensitivity. The aim of the present study was to evaluate the reproducibility of different microscopic methodologies and flow cytometry analysis to score γ-H2AX induction, and its suitability to distinguish a radiosensitive (RS) cell line from a radioresistant (RR) one.Materials and methods: γ-H2AX analyses were performed by semi-automated and automated microscopic methods and by flow cytometry before and after irradiation in two human lymphoblastoid cell lines and in lymphocytes from three healthy donors.Results: Reproducible results were obtained by all the methodologies tested, although not all showed the same sensitivity. The RS cell line always showed higher foci counts and higher levels of immunofluorescence intensity after irradiation than the RR cell line.Conclusions: Our results suggest that microscopic methodologies with z-stage capacity give the most accurate results after 1 Gy irradiation. However, for high doses of ionizing radiation, flow cytometry gives reliable results. Further studies will be necessary to determine the usefulness of γ-H2AX analysis to predict adverse side reactions in radiotherapy patients.
Size Dependent Deposition of Inhaled Nanoparticles in the Rat Respiratory Tract Using a New Nose-Only Exposure System
Creators: name: Buckley, Alison
name: Hodgson, Alan
name: Warren, James
name: Guo, Chang
name: Smith, Rachel
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Medicine
subject: Biophysics

description: ABSTRACTConcerns about the potential health effects of exposure to nanomaterials have led to a growing number of in vivo inhalation toxicity studies using nanoparticle aerosols. Estimates of aerosol deposition within the respiratory tract are important for these studies to enable: (a) the interpretation of the results, in particular, the evaluation of dose response relationships; (b) comparison with the results of other related studies; and (c) the extrapolation of results from animal models to human. Unfortunately only a limited number of studies have been undertaken to investigate respiratory tract deposition efficiencies for nano-sized aerosol particles. This is of particular importance as deposition efficiencies are predicted to vary significantly over the nano-size range for some elements of the respiratory tract. In this study female Wistar-Kyoto rats were exposed in a new design nose-only inhalation exposure system to spark generated radioactive iridium-192 nanoparticle aerosols of four particle sizes chosen to cover the majority of the nano-size range (nominal sizes: 10, 15, 35, and 75 nm). The content of iridium-192 in the lung, head, gastrointestinal tract and various other organs and tissues was measured. Aerosol deposition efficiencies in the whole respiratory tract and components (head airways, lung, alveolar region and tracheobronchial region) were estimated and compared with the predictions of the Multiple Path Particle Dosimetry (MPPD) model (v2.11). The experimentally derived deposition efficiencies were broadly consistent with, but typically higher than, model predictions and the results of comparable studies in the literature.
Eveningness relates to burnout and seasonal sleep and mood problems among young adults
Creators: name: Merikanto, Ilona
name: Suvisaari, Jaana
name: Lahti, Tuuli
name: Partonen, Timo
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Science Policy
subject: Cancer
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Earth and Environmental Sciences

description: Aims: Diurnal preference towards eveningness among adults has been associated with unhealthy habits and a range of health hazards, such as sleeping problems and higher odds for depression. We wanted to analyse whether diurnal preference towards eveningness is associated with more severe symptoms regarding sleep problems and mental disorders among young adults. Methods: Our sample consists of 469 young adults, aged 18–29 years, from the Mental Health in Early Adulthood Study in Finland (MEAF) conducted in 2003–2005. Chronotype was based on the assessment of one question that was asked first in 2000–2001 and the second time in 2003–2005. Those 73 participants who changed their chronotype were excluded from the main analysis, but separate analyses were performed with this group. Results: Concerning sleep, E-types reported higher dependency on alarm clocks (p < 0.001), and E-types and I-types had more problems in feeling refreshed after waking up (p < 0.0001 and p < 0.05 respectively) than M-types. Regarding mental health, E-types and I-types had lower odds for any lifetime DSM-IV Axis I disorder (p < 0.05 and p < 0.01 respectively) than M-types. Conclusions: Our results are in line with previous findings that those with the diurnal preference towards eveningness have more frequently three or more lifetime mental disorders, more sleeping problems, more seasonal variation in mood and behaviour, and more burnout compared with those with the diurnal preference towards morningness.