cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Use of a semi-physiological pharmacokinetic model to investigate the influence of itraconazole on tacrolimus absorption, distribution and metabolism in mice
Creators: name: Lu, Xue-Feng
name: Zhan, Jian
name: Zhou, Yang
name: Bi, Kai-Shun
name: Chen, Xiao-Hui
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health
subject: Virology
subject: Computational Biology

description: 1. The aim of this study was to investigate the influence of itraconazole (ITCZ) on tacrolimus absorption, distribution and metabolism by developing a semi-physiological pharmacokinetic model of tacrolimus in mice. 2. Mice were randomly divided into four groups, namely control group (CG, taking 3 mg kg−1 tacrolimus only), low-dose group (LDG, taking tacrolimus with 12.5 mg kg−1 ITCZ), medium-dose group (MDG, taking tacrolimus with 25 mg kg−1 ITCZ) and high-dose group (HDG, taking tacrolimus with 50 mg kg−1 ITCZ). 3. Liver clearance (CLli) decreased significantly (**p < 0.01) in LDG (35.3%), MDG (45.2%) and HDG (58.7%) mice compared to CG mice. With respect to gut clearance (CLgu), significant (**p < 0.01) decrease was also revealed in LDG (35.9%), MDG (50.2%) and HDG (64.6%) mice. A significant (**p < 0.01) higher tacrolimus brain-to-blood partition coefficient (Kt,br) was found in MDG (25.3%) and HDG (55.9%) mice than in CG mice. Moreover, a significant (*p < 0.05) increase (16.3%) was found in the absorption rate constant (Ka) in HDG mice compared to CG mice. There was a significant (**p < 0.01) association between ITCZ dose and the change in CLgu (ΔCLgu, r= −0.790), the change in CLli (ΔCLli, r= −0.787) and the change in Kt,br (ΔKt,br, r = 0.727), while the association between ITCZ dose and the change in Ka (ΔKa) was not significant (p > 0.05). 4. These findings could be useful in predicting the efficacy and toxicity of tacrolimus, and drug–drug interaction of ITCZ and tarcolimus in human.
The Role of Farmland in an Investment Portfolio: Analysis of Illinois Endowment Farms
Creators: name: Noland, Kevin
name: Norvell, Jonathan
name: Paulson, Nicholas D.
name: Schnitkey, Gary D.
name: Noland, Kevin
name: Norvell, Jonathan
name: Paulson, Nicholas D.
name: Schnitkey, Gary D.
Publisher: name: Unknown
Year: 2011
Subjects: Agricultural Finance

description: The recent financial crisis has renewed interest in alternative asset classes such as farmland. Previous work has shown that farmland may provide expected return premiums while adding little additional risk to a diversified portfolio. However, these studies have been based on relatively short time periods and aggregated data on farmland returns. This analysis contributes to this literature using farm-level data from the University of Illinois endowment farms, providing additional evidence that farmland could play a favorable role within an investment portfolio. The implications of these results extend to the use of farmland within general investment portfolios.
Nonlocality, Asymmetry, and Distinguishing Bipartite States
Creators: name: Walgate, Jonathan
name: Hardy, Lucien
Publisher: name: arXiv
Year: 2002
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Entanglement is an useful resource because some global operations cannot be locally implemented using classical communication. We prove a number of results about what is and is not locally possible. We focus on orthogonal states, which can always be globally distinguished. We establish the necessary and sufficient conditions for a general set of 2x2 quantum states to be locally distinguishable, and for a general set of 2xn quantum states to be distinguished given an initial measurement of the qubit. These results reveal a fundamental asymmetry to nonlocality, which is the origin of ``nonlocality without entanglement'', and we present a very simple proof of this phenomenon.
description: 5 pages, 1 figure. Improved in line with referees comments, references added, typo corrected. To appear in Phys. Rev. Lett
Additional file 9: of Contrast-induced acute kidney injury and adverse clinical outcomes risk in acute coronary syndrome patients undergoing percutaneous coronary intervention: a meta-analysis
Creators: name: Yang, Yi
name: George, Kaisha
name: Luo, Ran
name: Cheng, Yichun
name: Shang, Weifeng
name: Ge, Shuwang
name: Xu, Gang
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Hematology

description: Sensitivity analysis for stent restenosis. (PDF 92 kb)
Role of Single Defects in Electronic Transport through Carbon Nanotube Field-Effect Transistors
Creators: name: Freitag, Marcus
name: Kalinin, Sergei V.
name: Bonnell, Dawn A.
name: Johnson, A. T.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The influence of defects on electron transport in single-wall carbon nanotube field effect transistors (CNFETs) is probed by combined scanning gate microscopy (SGM) and scanning impedance microscopy (SIM). SGM reveals a localized field effect at discrete defects along the CNFET length. The depletion surface potential of individual defects is quantified from the SGM-imaged radius of the defect as a function of tip bias voltage. This provides a measure of the Fermi level at the defect with zero tip voltage, which is as small as 20 meV for the strongest defects. The effect of defects on transport is probed by SIM as a function of backgate and tip-gate voltage. When the backgate voltage is set so the CNFET is "on" (conducting), SIM reveals a uniform potential drop along its length, consistent with diffusive transport. In contrast, when the CNFET is "off", potential steps develop at the position of depleted defects. Finally, high-resolution imaging of a second set of weak defects is achieved in a new "tip-gated" SIM mode.
description: to appear in Physical Review Letters
The Medium of Visualization for Software Comprehension
Creators: name: Merino, Leonel
Publisher: name: Universität Bern
Year: 2018
Subjects: 000 Computer science, knowledge & systems
510 Mathematics

description: Although abundant studies have shown how visualization can help software developers to understand software systems, visualization is still not a common practice since developers (i) have little support to find a proper visualization for their needs, and once they find a suitable visualization tool, they (ii) are unsure of its effectiveness. We aim to offer support for identifying proper visualizations, and to increase the effectiveness of visualization techniques. In this dissertation, we characterize proposed software visualizations. To fill the gap between proposed visualizations and their practical application, we encapsulate such characteristics in an ontology, and propose a meta-visualization approach to find suitable visualizations. Amongst others characteristics of software visualizations, we identify that the medium used to display them can be a means to increase the effectiveness of visualization techniques for particular comprehension tasks.We implement visualization prototypes and validate our thesis via experiments. We found that even though developers using a physical 3D model medium required the least time to deal with tasks that involve identifying outliers, they perceived the least difficulty when visualizing systems based on the standard computer screen medium. Moreover, developers using immersive virtual reality obtained the highest recollection. We conclude that the effectiveness of software visualizations that use the city metaphor to support comprehension tasks can be increased when city visualizations are rendered in an appropriate medium. Furthermore, that visualization of software visualizations can be a suitable means for exploring their multiple characteristics that can be properly encapsulated in an ontology.
Chandra Spectral and Timing Analysis of Sgr A*'s Brightest X-ray Flares
Creators: name: Haggard, Daryl
name: Nynka, Melania
name: Mon, Brayden
name: Hernandez, Noelia de la Cruz
name: Nowak, Michael
name: Heinke, Craig
name: Neilsen, Joseph
name: Dexter, Jason
name: Fragile, P. Chris
name: Baganoff, Fred
name: Bower, Geoffrey C.
name: Corrales, Lia R.
name: Zelati, Francesco Coti
name: Degenaar, Nathalie
name: Markoff, Sera
name: Morris, Mark R.
name: Ponti, Gabriele
name: Rea, Nanda
name: Wilms, Joern
name: Yusef-Zadeh, Farhad
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We analyze the two brightest Chandra X-ray flares detected from Sagittarius A*, with peak luminosities more than 600 x and 245 x greater than the quiescent X-ray emission. The brightest flare has a distinctive double-peaked morphology --- it lasts 5.7 ksec ($\sim 2$ hours), with a rapid rise time of 1500 sec and a decay time of 2500 sec. The second flare lasts 3.4 ksec, with rise and decay times of 1700 sec and 1400 sec. These luminous flares are significantly harder than quiescence: the first has a power law spectral index $Γ= 2.06\pm 0.14$ and the second has $Γ= 2.03\pm 0.27$, compared to $Γ= 3.0\pm0.2$ for the quiescent accretion flow. These spectral indices (as well as the flare hardness ratios) are consistent with previously-detected Sgr A* flares, suggesting that bright and faint flares arise from similar physical processes. Leveraging the brightest flare's long duration and high signal-to-noise, we search for intraflare variability and detect excess X-ray power at a frequency of $ν\approx 3$ mHz, but show that it is an instrumental artifact and not of astrophysical origin. We find no other evidence (at the 95% confidence level) for periodic or quasi-periodic variability in either flares' time series. We also search for non-periodic excess power but do not find compelling evidence in the power spectrum. Bright flares like these remain our most promising avenue for identifying Sgr A*'s short timescale variability in the X-ray, which may probe the characteristic size scale for the X-ray emission region.
description: Updated to match published version; 19 pages, 7 figures, 3 tables
Table S3
Creators: name: Schneider, Dominik
Publisher: name: figshare
Year: 2021
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Detailed information of metagenome-assembled genome (MAG) bins extracted by MetaBAT2 from 17 co-assembled metagenome datasets (see Table S2).
MOESM8 of Promising prospects of nanopore sequencing for algal hologenomics and structural variation discovery
Creators: name: Sauvage, Thomas
name: Schmidt, William
name: Yoon, Hwan Su
name: Paul, Valerie
name: Fredericq, Suzanne
Publisher: name: figshare
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: Additional file 8: Figure S6. Bin reciprocity. Sankey plot depicting MyCC bin correspondence across Illumina and hybrid assembly files (Illumina PE + 1Df or 2D) and their taxonomy/origin in the Caulerpa ashmeadii holobiont based on COGs. Flow size linking bins represent the number of common scaffolds in the assembly files compared via reciprocal BLASTn. Numbers adjacent to bins represent the number of COGs reported by MyCC. Note the consistent delimitation of nuclear contigs but some instability in the binning of the Phyllobacteriaceae sp. and Rhodospirillaceae sp2. scaffolds. The Sankey diagram was built on the basis of html code available from Google Charts at https://developers.google.com/chart/interactive/docs/gallery/sankey. PE = Illumina Paired-Ends scaffolds, PE+1Df = hybrid 1Df scaffolds, PE+2D = hybrid 2D scaffolds.
Quadraceps anagrapsus
Creators: name: Ilieva, Mihaela
Publisher: name: Zenodo
Year: 2009
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Psocodea
Philopteridae
Quadraceps
Quadraceps anagrapsus

description: Quadraceps anagrapsus (Nitzsch, 1866)
 Report: [1] Touleshkov (1960a).
 Synonym: Quadraceps pagasti Eichler [1].
 Hosts: Chlidonias hybridus (Pallas) [1]; C. leucopterus (Temminck) [1].
 Distribution in Bulgaria: Popina (Silistra Region), Chelopechene (Sofia Region) [1].
description: Published as part of Ilieva, Mihaela, 2009, Checklist of the chewing lice (Insecta: Phthiraptera) from wild birds in Bulgaria, pp. 1-66 in Zootaxa 2138 (1) on page 40, DOI: 10.11646/zootaxa.2138.1.1, http://zenodo.org/record/5314302
Cluster of Dipolar Coupled Spins as a Quantum Memory Storage
Creators: name: Khitrin, A. K.
name: Ermakov, V. L.
name: Fung, B. M.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Spin dynamics of a cluster of coupled spins 1/2 can be manipulated to store and process a large amount of information. A new type of dynamic response makes it possible to excite coherent long-living signals, which can be used for exchanging information with a mesoscopic quantum system. An experimental demonstration is given for a system of 19 proton spins of a liquid crystal molecule.
description: 5 pages, 1 figure
Moldable tools
Creators: name: Chis, Vasile-Andrei
Publisher: name: Universität Bern
Year: 2016
Subjects: 000 Computer science, knowledge & systems
510 Mathematics

description: Development tools are a prerequisite for crafting software. They offer the lenses through which developers perceive and reason about their software systems. Generic development tools, while having a wide range of applicability, ignore the contextual nature of software systems and do not allow developers to directly reason in terms of domain abstractions. Domain-specific development tools, tailored to particular application domains, can address this problem. While it has clear advantages, incorporating domain abstractions into development tools is a challenging activity. The wide range of domains and contextual tasks that development tools need to support leads to costly or ad hoc mechanisms to incorporate and discover domain abstractions. Inherently, this limits developers from taking advantage of domain-specific information during the development and maintenance of their systems. To overcome this problem, we propose to embed domain abstractions into development tools through the design of moldable tools that support the inexpensive creation of domain-specific extensions capturing domain abstractions, and that automatically select extensions based on the domain model and the developer’s interaction with the domain model. This solution aims to reduce the cost of creating extensions. Towards this goal, it provides precise extension points together with internal DSLs for configuring common types of extensions. This solution facilitates automatic discovery by enabling extension creators to specify together with an extension an activation predicate that captures the context in which that extension is applicable. We validate the moldable tools approach by applying it, in the context of objectoriented applications, to improve three development activities, namely: reasoning about run-time objects, searching for domain-specific artifacts, and reasoning about run-time behavior. For each activity we identify limitations of current tools, show how redesigning those tools following the moldable tools approach addresses the identified limitations, and discuss the cost for creating domain-specific extensions. We demonstrate that moldable tools address an existing need by analyzing the increase in domain-specific extensions after we integrated the moldable tools solving the aforementioned tasks with an IDE. We also show what kinds of custom environments developers can create by continuously adapting their development tools.
EFFECTS OF CURING REGIMES ON MECHANICAL STRENGTH AND DURABILITY OF ALKALI-ACTIVATED LOW REACTIVE VOLCANIC ASHES
Creators: name: J. Baenla B. Djon
Publisher: name: Zenodo
Year: 2024

description: This study evaluated the effects of curing regime on mechanical strength and durability of synthesized products obtained from alkaline activation of two low reactive volcanic ashes. Thus, alkaline activation of volcanic ashes was performed according to three different curing regimes: sealing specimens in polyethylene bags at ambient temperature of the laboratory (SSP25), maintaining specimens in open atmospheric air of the laboratory (SOA25) and oven drying specimens at 60 °C (ODS60). Depending on the raw aluminosilicates and alkali activated products, chemical analysis, SEM (Scanning Electron Microscopy) and XRD (X-Ray Diffraction) were carried out. The SSP25 curing regime favoured high dissolution of phases in volcanic ash but led to low polycondensation due to high water retention, hence synthesized products with low mechanical strength and poor durability. Conversely, ODS60 and SOA25 curing regimes showed great degree of polycondensation which was highlighted respectively by synthesized products with high compressive strength and good stability in acid. Besides, the volcanic ash sample with lowest reactive phase content (18% by mass) demonstrated specimens with high durability in acid medium in terms of mass loss together with increase of residual compressive strength compared to volcanic ash with reactive phase content of 26% by mass. Hence, during alkaline activation of low reactive volcanic ashes, ODS60 or SOA25 were the effective curing regimes for the development of synthesized products with high mechanical strength and good durability.
Three Essays on Innovation and Precautionary Cash Holdings
Creators: name: Aebischer, Stefan
Publisher: name: Universität Bern
Year: 2016
Subjects: 650 Management & public relations

description: This thesis consists of three papers that investigate firms’ management of innovation and precautionary cash holdings. The first paper examines innovation efforts and abilities of firms at different stages in the lifecycle. The study exploits unique firm data on investments and sales related to innovation from six waves of the Swiss Innovation Survey between 1996 and 2011. Using firm age to identify established firms, I find that established firms, compared to young firms, invest less in innovation and are less efficient in producing innovation output within the firm. By contrast, established firms are more efficient in using knowledge from outside the firm (e.g., from suppliers, competitors, universities) to produce innovation output. These results largely do not depend on whether the innovation output is incremental or radical in nature. These findings suggest that young and established firms differ in the allocation and productivity of innovation resources. The second paper examines the importance of the precautionary motive relative to other motives as a determinant of corporate cash holdings. According to the precautionary motive, firms facing future financing constraints hold cash to ensure that they can make investments or meet obligations. I develop an index that includes the precautionary information of six popular firm-level measures: cash flows, cash flow volatility, R&D intensity, market-to-book, net working capital and product market competition. The index explains 32% of the variation in corporate cash holdings and increases to 41% when using the debt and equity constraint indices of Hoberg and Maksimovic (2015) as additional precautionary measures. As the predominant cash determinant, the precautionary motive is particularly strong for firms that face greater opportunity costs of disclosing proprietary information. This finding is consistent with the notion that these firms are more reliant on precautionary cash to protect proprietary information that they otherwise have to disclose to investors to reduce equity constraints. The third paper investigates whether the debt or equity capital supply shock of the recent financial crisis (2007-2009) caused firms to use precautionary cash holdings to mitigate underinvestment. I find that precautionary cash was used to substitute for the decline in net equity issuance but not net debt issuance. I also find that precautionary cash was used by equity- but not debt-constrained firms to mitigate underinvestment during the crisis. Consistently, precautionary cash was not used in the absence of the equity supply shock, i.e., during placebo crises or during the economy-wide demand shock following the financial crisis. This paper provides new evidence on the importance of corporate liquidity management for equity-constrained firms and identifies the crisis’ equity capital supply shock as a dominant first-order effect on corporate financial policies.
MOESM9 of Promising prospects of nanopore sequencing for algal hologenomics and structural variation discovery
Creators: name: Sauvage, Thomas
name: Schmidt, William
name: Yoon, Hwan Su
name: Paul, Valerie
name: Fredericq, Suzanne
Publisher: name: figshare
Year: 2019
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file 9: Figure S7. Metagenome binning. Comparison of delimited bins with MyCC (4mer) for three assemblies. (a) Experimental binning of Canu 1Df contigs. (b) Binning of Spades’ hybrid Illumina+1Df assembly. (c) Binning of Spades’ Illumina-only assembly. Bins containing nuclear and repeat contigs are emphasized with dashed circles. Remaining bins correspond to bacterial taxa. Note that printed bin numbers are unrelated between plots.
Entanglement sharing in one-particle states
Creators: name: Lakshminarayan, Arul
name: Subrahmanyam, V.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Quantum Physics (quant-ph)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: Entanglement sharing among sites of one-particle states is considered using the measure of concurrence. These are the simplest in an hierarchy of number-specific states of many qubits and corresponds to ``one-magnon'' states of spins. We study the effects of onsite potentials that are both integrable and nonintegrable. In the integrable case we point to a metal-insulator transition that reflects on the way entanglement is shared. In the nonintegrable case the average entanglement content increases and saturates along with a transition to classical chaos. Such quantum chaotic states are shown to have universal concurrence distributions that are modified Bessel functions derivable within random matrix theory. Time-reversal breaking and time evolving states are shown to possess significantly higher entanglement sharing capacity that eigenstates of time-reversal symmetric systems. We use the ordinary Harper and kicked Harper Hamiltonians as model systems.
description: 14 Pages, Revtex4. Corrected typos, enlarged content, bigger introduction and more discussions. Final version that will appear in Phys. Rev. A (May, 2003)
State-dependent optical lattices for the strontium optical qubit
Creators: name: Heinz, A.
name: Park, A. J.
name: Šantić, N.
name: Trautmann, J.
name: Porsev, S. G.
name: Safronova, M. S.
name: Bloch, I.
name: Blatt, S.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We demonstrate state-dependent optical lattices for the Sr optical qubit at the tune-out wavelength for its ground state. We tightly trap excited state atoms while suppressing the effect of the lattice on ground state atoms by more than four orders of magnitude. This highly independent control over the qubit states removes inelastic excited state collisions as the main obstacle for quantum simulation and computation schemes based on the Sr optical qubit. Our results also reveal large discrepancies in the atomic data used to calibrate the largest systematic effect of Sr optical lattice clocks.
description: 6 pages, 4 figures + 6 pages supplemental material
Minnesota Farm Management Service Notes No. 35
Creators: name: Hoverstad, Andrew T.
name: Pond, George A.
name: Hoverstad, Andrew T.
name: Pond, George A.
Publisher: name: Unknown
Year: 1925
Subjects: Livestock Production/Industries

description: Does the Farm Poultry Flock Pay?; How can the poultry profits be increased?; What is the outlook for egg and poultry prices?
Minnesota Farm Management Service Notes No. 36
Creators: name: Boss, Andrew
name: Pond, George A.
name: Cavert, W.L.
name: Boss, Andrew
name: Pond, George A.
name: Cavert, W.L.
Publisher: name: Unknown
Year: 1925
Subjects: Agricultural Finance
Farm Management

description: Why Keep Accounts?; What records should a farmer keep?; Assistance in farm accounting
Developing a Gaucher Disease Pharmacological Model of the Blood-Brain Barrier
Creators: name: Selvadoss, Andrew
Publisher: name: Digital Repository at the University of Maryland
Year: 2021
Subjects: Gaucher Disease
Drug Delivery
GCase
Lysosomal Storage Disease
Blood-Brain Barrier
Neurons
Astrocytes
Endothelial Cells
HBMEC
Fibroblasts

description: Gaucher disease is a genetic disorder that leads to the lysosomal enzyme glucocerebrosidase (GCase) being unable to function correctly. The enzyme breaks down glucocerebroside (GluCer) and in the case of Gaucher disease, a buildup of GluCer leads to various conditions which can often be neuropathic. A common treatment for Gaucher disease and other lysosomal storage diseases is enzyme replacement therapy, which consists of intravenously delivered recombinant enzymes. However, this treatment has an inability to treat the central nervous system (CNS) because of its inability to cross the blood-brain barrier (BBB). In vitro studies with Gaucher afflicted BBB cellular systems are needed to test the delivery of novel recombinant enzymes across the BBB. These experiments however are severely limited by the scarcity and expense of Gaucher endothelial cells, astrocytes, and neurons, which compose the BBB. This project's goal was to develop a pharmacological model of Gaucher disease using cellular systems involving treating healthy endothelial cells, astrocytes, to exhibit the Gaucher phenotype, and iPS service Gaucher neurons. First, cellular systems were treated with conduritol beta-epoxide (CBE), an inhibitor of GCase. Treatment with CBE lowered GCase activity and increased GluCer accumulation in both cell types, and to a similar extent as a genetic model- Gaucher skin fibroblasts. An in vitro model of the Gaucher BBB was created using a transwell system with CBE treated endothelial cells on the apical side, astrocytes on the basal side of the filter and iPS service Gaucher neurons in the basal well. Transport of GCase, modified to transcytose more efficiently was tested on the Gaucher BBB model, where more efficient transcytosis, lysosomal colocalization, and effects were observed when compared to control GCase. This model presents a promising step towards testing potential therapeutics for Gaucher disease.
MOESM10 of Immunogenicity of Del19 EGFR mutations in Chinese patients affected by lung adenocarcinoma
Creators: name: Pan, Deng
name: Dapeng Zhou
name: Weijing Cai
name: Weibo Wu
name: Tan, Wen
name: Caicun Zhou
name: Yanyan Lou
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Additional file 10. Predicted HLA binding epitopes for EGFR delL747_P753.
Investigation of robotics-assisted tilt table technology for cardiopulmonary exercise testing in stroke patients
Creators: name: Saengsuwan, Jittima
Publisher: name: Universität Bern
Year: 2016
Subjects: 570 Life sciences; biology
610 Medicine & health

description: Due to the lack of exercise testing devices that can be employed in stroke patients with severe disability, the aim of this PhD research was to investigate the clinical feasibility of using a robotics-assisted tilt table (RATT) as a method for cardiopulmonary exercise testing (CPET) and exercise training in stroke patients. For this purpose, the RATT was augmented with force sensors, a visual feedback system and a work rate calculation algorithm. As the RATT had not been used previously for CPET, the first phase of this project focused on a feasibility study in 11 healthy able-bodied subjects. The results demonstrated substantial cardiopulmonary responses, no complications were found, and the method was deemed feasible. The second phase was to analyse validity and test-retest reliability of the primary CPET parameters obtained from the RATT in 18 healthy able-bodied subjects and to compare the outcomes to those obtained from standard exercise testing devices (a cycle ergometer and a treadmill). The results demonstrated that peak oxygen uptake (V'O2peak) and oxygen uptake at the submaximal exercise thresholds on the RATT were ̴20% lower than for the cycle ergometer and ̴30% lower than on the treadmill. A very high correlation was found between the RATT vs the cycle ergometer V'O2peak and the RATT vs the treadmill V'O2peak. Test-retest reliability of CPET parameters obtained from the RATT were similarly high to those for standard exercise testing devices. These findings suggested that the RATT is a valid and reliable device for CPET and that it has potential to be used in severely impaired patients. Thus, the third phase was to investigate using the RATT for CPET and exercise training in 8 severely disabled stroke patients. The method was technically implementable, well tolerated by the patients, and substantial cardiopulmonary responses were observed. Additionally, all patients could exercise at the recommended training intensity for 10 min bouts. Finally, an investigation of test-retest reliability and four-week changes in cardiopulmonary fitness was carried out in 17 stroke patients with various degrees of disability. Good to excellent test-retest reliability and repeatability were found for the main CPET variables. There was no significant difference in most CPET parameters over four weeks. In conclusion, based on the demonstrated validity, reliability and repeatability, the RATT was found to be a feasible and appropriate alternative exercise testing and training device for patients who have limitations for use of standard devices.
When the Transition Temperature in Color Superconductors is Not Like in BCS Theory
Creators: name: Schmitt, Andreas
name: Wang, Qun
name: Rischke, Dirk H.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Nuclear Theory (nucl-th)
subject: Superconductivity (cond-mat.supr-con)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study color superconductivity with $N_f=1,2,$ and 3 massless flavors of quarks. We present a general formalism to derive and solve the gap equations for condensation in the even-parity channel. This formalism shows that the leading-order contribution to the gap equation is unique for all color superconductors studied here, and that differences arise solely at the subleading order. We discuss a simple method to compute subleading contributions from the integration over gluon momenta in the gap equation. Subleading contributions enter the prefactor of the color-superconducting gap parameter. In the case of color-flavor and color-spin locking we identify further corrections to this prefactor arising from the two-gap structure of the quasiparticle excitations. Computing the transition temperature, $T_c$, where the color-superconducting condensate melts, we find that these contributions lead to deviations from the BCS behavior $T_c\simeq 0.57 ϕ_0$, where $ϕ_0$ is the magnitude of the zero-temperature gap at the Fermi surface.
description: 22 pages, Revtex, no figures
Nonlinear superposition formula for N=1 supersymmetric KdV Equation
Creators: name: Liu, Q. P.
name: Xie, Y. F.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences

description: In this paper, we derive a Bäcklund transformation for the supersymmetric Kortweg-de Vries equation. We also construct a nonlinear superposition formula, which allows us to rebuild systematically for the supersymmetric KdV equation the soliton solutions of Carstea, Ramani and Grammaticos.
description: 6 pages, LaTeX, everthing is reformed into super fields
Constraints on the occurrence and distribution of 1--20 \mj\ companions to stars at separations of 5--5000\,au from a compilation of direct imaging surveys
Creators: name: Baron, Frédérique
name: Lafrenière, David
name: Artigau, Étienne
name: Gagné, Jonathan
name: Rameau, Julien
name: Delorme, Philippe
name: Naud, Marie-Eve
Publisher: name: arXiv
Year: 2019
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present the first statistical analysis of exoplanet direct imaging surveys combining adaptive optics imaging at small separations with deep seeing-limited observations at large separations allowing us to study the entire orbital separation domain from 5 to 5000~au simultaneously. Our sample of 344 stars includes only confirmed members of nearby young associations and is based on all AO direct-imaging detection limits readily available online, with addition of our own previous seeing limited surveys. Assuming that the companion distribution in mass and semi-major axis follows a power law distribution and adding a dependence on the mass of the host star, such as $d^2n\propto fM^αa^β (M_\star/M_{\odot})^γ$d$ M $d$a$, we constrain the parameters to obtained $α=-0.18^{+0.77}_{-0.65}$, $β=-1.43^{+0.23}_{-0.24}$, and $γ=0.62^{+0.56}_{-0.50}$,at a 68\% confidence level, and we obtain $f=0.11^{+0.11}_{-0.05}$, for the overall planet occurrence rate for companions with masses between 1 to 20~\mj\ in the range 5--5000~au. Thus, we find that occurrence of companions is negatively correlated with semi-major axis and companion mass (marginally) but is positively correlated with the stellar host mass. Our inferred mass distribution is in good agreement with other distributions found previously from direct imaging surveys for planets and brown dwarfs, but is shallower as a function of mass than the distributions inferred by radial velocity surveys of gas giants in the 1--3\,au range. This may suggest that planets at these wide and very-wide separations represent the low-mass tail of the brown dwarfs and stellar companion distribution rather than an extension of the distribution of the inner planets.
description: 26 pages, 8 figures Accepted to Astronomical Journal Updated Table 4
Oberflächenveränderung verschiedener zahnmedizinischer Werkstoffe nach in-vitro Alterung
Creators: name: Kuster, Daniela
Publisher: name: Universität Bern
Year: 2014
Subjects: 610 Medicine & health

description: Susceptibility of different restorative materials to toothbrush abrasion and coffee staining Objective: The aim of this study was to evaluate the susceptibility of different restorative materials to surface alterations after an aging simulation. Methods: Specimens (n=15 per material) of five different restorative materials (CER: ceramic/Vita Mark II; EMP: composite/Empress Direct; LAV: CAD/CAM composite/Lava Ultimate; COM: prefabricated composite/Componeer; VEN: prefabricated composite/Venear) were produced. Whereas CER was glazed, EMP and LAV were polished with silicon polishers, and COM and VEN were left untreated. Mean roughness (Ra and Rz) and colorimetric parameters (L*a*b*), expressed as colour change (E), were measured. The specimens underwent an artificial aging procedure. After baseline measurements (M1), the specimens were successively immersed for 24 hours in coffee (M2), abraded in a toothbrushing simulator (M3), immersed in coffee (M4), abraded (M5) and repeatedly abraded (M6). After each aging procedure (M2-M6), surface roughness and colorimetric parameters were recorded. Differences between the materials regarding Ra/Rz and E were analysed with a nonparametric ANOVA analysis. The level of significance was set at α=0.05. Results: The lowest roughness values were obtained for CER. A significant increase in Ra was detected for EMP, COM and VEN compared to CER. The Ra/Rz values were found to be highly significantly different for the materials and measuring times (M) (p<0.0001). Regarding E most alterations were found for EMP and COM, whereas CER and LAV remained mostly stable. The E values were significantly different for the materials and M (p<0.0001). Conclusion: The ceramic and the CAD/CAM composite were the most stable materials with regard to roughness and colour change and the only materials that resulted in Ra values below 0.2 μm (the clinically relevant threshold). Venears and Componeers were more inert than the direct composite material and thus might be an alternative for extensive restorations in the aesthetic zone.
Quadraceps auratus
Creators: name: Ilieva, Mihaela
Publisher: name: Zenodo
Year: 2009
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Psocodea
Philopteridae
Quadraceps
Quadraceps auratus

description: Quadraceps auratus (De Haan, 1829)
 Report: [1] Touleshkov (1964b).
 Host: Haematopus ostralegus L. [1].
 Distribution in Bulgaria: Stara Zagora, Chelopechene (Sofia Region) [1].
description: Published as part of Ilieva, Mihaela, 2009, Checklist of the chewing lice (Insecta: Phthiraptera) from wild birds in Bulgaria, pp. 1-66 in Zootaxa 2138 (1) on page 40, DOI: 10.11646/zootaxa.2138.1.1, http://zenodo.org/record/5314302
Search for t->ch at e+e- Linear Colliders
Creators: name: Han, Tao
name: Jiang, Jing
name: Sher, Marc
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the rare top-quark decay t->ch, where h is a generic Higgs boson, at a linear collider. If kinematically accessible, all models contain this decay at some level due to quark flavor mixing. Some models, such as Model III of the two-Higgs doublet model, have a tree-level top-charm-Higgs coupling, and the branching ratio is close to 0.5%. Others, such as the MSSM, have a coupling induced at one-loop, and can have a branching ratio in the range of 10^{-5} - 5x10^{-4}. We find that a linear collider of root(s) = 500 GeV and a luminosity of 500 fb^{-1} will begin to be sensitive to this range of the coupling.
description: 12 pages, 5 figures, 2 tables
Evidence for Unconventional Strong-coupling Superconductivity in PrOs_4Sb_12 : An Sb Nuclear Quadrupole Resonance (NQR) Study
Creators: name: Kotegawa, H.
name: Yogi, M.
name: Imamura, Y.
name: Kawasaki, Y.
name: Zheng, G. -q.
name: Kitaoka, Y.
name: Ohsaki, S.
name: Sugawara, H.
name: Aoki, Y.
name: Sato, H.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We report Sb-NQR results which evidence a heavy-fermion (HF) behavior and an unconventional superconducting (SC) property in the filled-skutterudite compound PrOs_4Sb_12 revealing a SC transition temperature T_c=1.85 K. The temperature (T) dependence of nuclear-spin-lattice-relaxation rate 1/T_1 and NQR frequency unravel a low-lying crystal-electric-field splitting below T_0~10 K, associated with Pr^3+ (4f^2)-derived ground state. The emergence of T_1T=const. behavior below T_F~4 K points to the formation of heavy-quasiparticle state. In the SC state, 1/T_1 shows neither a coherence peak nor a T^3like power-law behavior observed for HF superconductors to date. The isotropic energy-gap with a size of gap Delta/k_B=4.8 K begins to already open up at T^*~2.3 K without any coherence effect just below T_c=1.85 K. We highlight that the superconductivity in PrOs_4Sb_12, which is in an unconventional strong-coupling regime, differs from a conventional s-wave type and any unconventional ones with the line-node gap.
Bystander Responses to College Dating Violence: Can We Educate Undergraduate Students Using an Online Intervention?
Creators: name: Herman, Micah
Publisher: name: Digital Repository at the University of Maryland
Year: 2020
Subjects: dating violence
abuse
college students
online intervention
peer support

description: The purposes of this study were to improve an online bystander intervention educational program (STOP Dating Violence; O'Brien et al., 2019) and conduct a randomized controlled trial to test the effectiveness of this revised intervention. Specifically, the intervention was modified and converted into an engaging animated video and then tested for its effectiveness. College students (N=335) were randomly assigned to one of three conditions: (1) the STOP intervention, (2) a website containing information about dating violence, and (3) a control condition. Results indicated that students who viewed the STOP Dating Violence video intervention had the greatest knowledge of bystander interventions when compared to the website and control conditions. Thus, the STOP Dating Violence video has the potential to successfully educate undergraduates about appropriate bystander interventions for dating violence in a cost-effective manner.
MOESM4 of The Atlantis Bank Gabbro Massif, Southwest Indian Ridge
Creators: name: Dick, Henry
name: Kvassnes, Astri
name: Robinson, Paul
name: MacLeod, Christopher
name: Hajimu Kinoshita
Publisher: name: figshare
Year: 2019
Subjects: subject: Space Science
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Marine Biology
subject: Computational Biology

description: Additional file 4. Supplemental Table IV. Augite Trace Element Compositions.
Testing the Accuracy of Halo Occupation Distribution Modelling using Hydrodynamic Simulations
Creators: name: Beltz-Mohrmann, Gillian D.
name: Berlind, Andreas A.
name: Szewciw, Adam O.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Halo models provide a simple and computationally inexpensive way to investigate the connection between galaxies and their dark matter haloes. However, these models rely on the assumption that the role of baryons can be easily parametrized in the modelling procedure. We aim to examine the ability of halo occupation distribution (HOD) modelling to reproduce the galaxy clustering found in two different hydrodynamic simulations, Illustris and EAGLE. For each simulation, we measure several galaxy clustering statistics on two different luminosity threshold samples. We then apply a simple five parameter HOD, which was fit to each simulation separately, to the corresponding dark matter only simulations, and measure the same clustering statistics. We find that the halo mass function is shifted to lower masses in the hydrodynamic simulations, resulting in a galaxy number density that is too high when an HOD is applied to the dark matter only simulation. However, the exact way in which baryons alter the mass function is remarkably different in the two simulations. After applying a correction to the halo mass function in each simulation, the HOD is able to accurately reproduce all clustering statistics for the high luminosity sample of galaxies. For the low luminosity sample, we find evidence that in addition to correcting the halo mass function, including spatial, velocity, and assembly bias parameters in the HOD is necessary to accurately reproduce clustering statistics.
description: 20 pages, 9 figures, accepted by MNRAS
Quadraceps baliola
Creators: name: Ilieva, Mihaela
Publisher: name: Zenodo
Year: 2009
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Psocodea
Philopteridae
Quadraceps
Quadraceps baliola

description: Quadraceps baliola (Blagoveshtchensky, 1951)
 Report: [1] Touleshkov (1960a).
 Host: Sterna nilotica Gmelin [1].
 Distribution in Bulgaria: Burgas [1].
description: Published as part of Ilieva, Mihaela, 2009, Checklist of the chewing lice (Insecta: Phthiraptera) from wild birds in Bulgaria, pp. 1-66 in Zootaxa 2138 (1) on page 40, DOI: 10.11646/zootaxa.2138.1.1, http://zenodo.org/record/5314302
Deformation of CHS model
Creators: name: Suyama, Takao
Publisher: name: arXiv
Year: 2002
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We calculate mass spectrum of CHS model deformed by an exactly marginal operator, and find that there are tachyons which are not localized in the target space. Similar deformation is discussed in another CFT which corresponds to separated NS5-branes. A condensation of the tachyons is briefly argued.
description: 12 pages
Out-of-plane QCD radiation in hadronic Z0 production
Creators: name: Banfi, A.
name: Marchesini, G.
name: Smye, G.
name: Zanderighi, G.
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present the QCD analysis of the cumulative out-of-event-plane momentum distribution in the process proton-antiproton into Z0 and a hard jet (event plane defined by the proton, antiproton and Z0 momenta). Particular attention is placed on the near-to-planar events for which we derive the all-order resummed result to next-to-leading accuracy. We consider also the leading power correction originating from the fact that, even in hard processes, the resummed QCD coupling runs into the infrared region. We aim at the same level of accuracy which, in e+e- annihilation, seems to be sufficient for making predictions. Contributions from a ``soft underlying event'' due to beam remnant interactions are discussed. Experimental data (not yet available) are needed to cast light on the predictive level of standard QCD analysis in hard hadron-hadron collisions. We plot examples of the predicted distribution at Tevatron energies. The techniques here developed can be extended to other hard hadron-hadron and hadron-lepton processes.
description: 36 pages, 3 figures, JHEP class included
Accelerator modes of square well system
Creators: name: Sankaranarayanan, R.
name: Sheorey, V. B.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We study accelerator modes of a particle, confined in an one-dimensional infinite square well potential, subjected to a time-periodic pulsed field. Dynamics of such a particle can be described by one generalization of the kicked rotor. In comparison with the kicked rotor, this generalization is shown to have a much larger parametric space for existence of the modes. Using this freedom we provide evidence that accelerator mode assisted anomalous transport is greatly enhanced when low order resonances are exposed at the border of chaos. We also present signature of the enhanced transport in the quantum domain.
description: 7 pages, 5 figures, revtex4