cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Comparative phytochemical property and antioxidant activity of sixteen Mei (Prunus mume) fruit cultivars from six provinces in China
Creators: name: Liu, Zhihua
name: Yang, Yezi
name: Sun, Chongzhi
name: Wu, Yang
name: Li, Xiaobo
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: Mei (Prunus mume) is widely planted in Eastern Asian countries. To evaluate the effect of cultivar and producing origin on the quality of Mei fruit, we studied the phytochemical properties and antioxidant activities of the 16 Mei fruit cultivars from 6 provinces in China, as well as their profiles of 121 volatile compounds, 5 organic acids, 13 minerals, 24 amino acids and 3 active peptides. Multivariate analysis revealed that the four Mei fruit cultivars with a drier climate in Yunnan province had the characteristics of low water moistures and proteins contents, high total acids, soluble solids, flavones, and phenols contents, and high antioxidant activities, which could be distinguished from fruits of other producing areas. Further component analysis showed that Mei fruits were rich in volatile compounds, organic acids (such as citric acid and malic acid), minerals (such as K, Ca, Mg, P, and Fe), and amino acids (such as Orn, Asn, and Asp), and the nutrient composition ratio in different cultivars was different. In conclusion, Mei fruits can be used as nutritious health food and different cultivars focus on different nutritional compositions.
Evidence for The Early 16th-Century Surrey-Hampshire Border Ware Industry from the City of London
Creators: name: Pearce, Jacqueline
Publisher: name: Archaeology Data Service
Year: 2023

description: Medieval Ceramics: Journal of the Medieval Ceramics Research Group, 21, 43-60
description: An early 16th-century phase of redware production in the pottery industry of the Surrey-Hampshire borders is proposed on the basis of the unique find of a considerable quantity of fine, glazed redware cups from a single site at Cripplegate in the City of London. Following petrological examination and comparison with the products of various contemporaneous ceramic industries supplying London, the term Early Red Border ware is proposed for this previously unrecognised fabric, a typology is presented and reasons are suggested for the deposition of a single type of pottery in such large numbers in one area of the City alone. An early 16th-century phase of fine whiteware production in the Border industry is also proposed as intermediate between the manufacture of 'Tudor Green' ware and the introduction of Border ware proper in the mid 16th century.
Longitudinal Follow-up of Impedance Drift in Deep Brain Stimulation Cases
Creators: name: Wong, Joshua
name: Gunduz, Aysegul
name: Shute, Jonathan
name: Eisinger, Robert
name: Cernera, Stephanie
name: Ho, Kwo Wei David
name: Martinez-Ramirez, Daniel
name: Almeida, Leonardo
name: Wilson, Christina A.
name: Okun, Michael S.
name: Hess, Christopher W.
Publisher: name: Columbia University
Year: 2018
Subjects: subject: Brain stimulation
subject: Neurosciences
subject: FOS: Clinical medicine
subject: Impedance, Bioelectric
subject: Biomedical engineering
subject: Parkinson's disease

description: Background: Impedance is an integral property of neuromodulation devices that determines the current delivered to brain tissue. Long-term variability in therapeutic impedance following deep brain stimulation (DBS) has not been extensively investigated across different brain targets. The aim was to evaluate DBS impedance drift and variability over an extended postoperative period across common DBS targets.

Methods: Retrospective data from 1,764 electrode leads were included and drawn from 866 DBS patients enrolled in the University of Florida Institutional Review Board-approved INFORM database and analyzed up to 84 months post implantation. An exploratory analysis was conducted to identify trends in impedances using a Mann–Kendall test of trend.

Results: There were 866 patients and 1,764 leads available for analysis. The majority of subjects had Parkinson’s disease (60.7%). The mean age at implantation was 58.7 years old and the mean follow-up time was 36.8 months. There were significant fluctuations in the mean impedance of all electrodes analyzed that largely stabilized by 6 months except for the subthalamic nucleus (STN) target, in which fluctuations persisted throughout the duration of follow-up with a continued downward trend (p < 0.001).

Discussion: The drift in impedance observed primarily within the first 6 months is in keeping with prior studies and is likely due to surgical micro-lesioning effects and brain parenchyma remodeling at the electrode–tissue interface, typically at values approximating 1,000 Ω. The differences in impedance trends over time in the various DBS targets may be due to underlying differences in structure and tissue composition.
Imaging and Data Analysis as a Support for Diagnosis and Rehabilitation Practice
Creators: name: TROMBINI, MARCO
Publisher: name: Universit� degli studi di Genova
Year: 2022

description: In the last years, medical technologies have acquired a fundamental role in the clinical practice. Indeed, they are employed in all the stages of patients? treatment, ranging from diagnosis to rehabilitation.
Medical imaging is an umbrella term covering several medical technologies for diagnosis. Images and volumes are useful in the analysis of tissues and anatomical structures, enabling an accurate understanding of the phenomena and a quantitative dynamic anal- ysis associated with longitudinal studies.
In addition, Information and Communication Technologies (ICT) are a concrete answer to many needs in the healthcare framework since they enable remote support for patients, thus fostering conti- nuity of care and personalized rehabilitation plans.
The aim of the present work is the development and use of medical technologies that take into account the global patient?s medical journey. In particular, the focus is on both diagnosis and rehabili- tation, as indeed they are strictly connected procedures.
The two research themes are disclosed in parallel. After the technical disclosure, their deployment into real scenarios is described, by referring to particular diseases.
The integration of medical technologies for diagnosis and rehabilitation is straightforward, and thus a general pipeline combining them is proposed as future development of the present work.
Identification and validation of CDK13 interacting proteins
Creators: name: Chun, Stella Soyoung
Publisher: name: University of British Columbia
Year: 2012

description: Cyclin dependent kinases (CDKs) are components of signal transduction pathways that regulate cellular functions by phosphorylation of substrate proteins in response to upstream signals. The kinase domains of CDK12 and CDK13 are most similar to CDK9; CDK9 phosphorylates the C terminal domain (CTD) of RNA Polymerase II in order to stimulate processive transcription elongation. However, while most human CDKs consist of little more than a kinase domain, CDK12 and CDK13 are much larger and have several protein-protein interaction domains suggesting that they could participate within regulatory cascades. They also have a RS domain found in the SR protein family of splicing factors. Consistent with these features CDK12 and CDK13 co-localize with splicing factors and RNA Polymerase II in nuclear speckles. Based on these features CDK12 and CDK13 have been proposed to coordinately regulate splicing and transcription. Consistent with this hypothesis, both kinases phosphorylate the CTD of RNA polymerase II and regulate the alternative splicing of the Adenovirus E1a mini-gene model substrate. CDK12 has been found to interact with the splicing factors PRP19, CDC5L, RBM25, FBP11 and SRP55. Due to the similarity of CDK13 to CDK12, I investigated the interacting partners of CDK13 by immunoprecipitation and mass spectrometry and determined that CDK13 interacts with same splicing factors as CDK12. These interactions were validated by immunoprecipitation – western blot analysis. My results also indicated that PRP19 and CDC5L interact as a complex with CDK13. Therefore, the protein interaction partners of CDK13 and CDK12 suggest functional mechanisms for their ability to regulate splicing. In parallel projects, to begin investigating the functional roles of the kinase domain of CDK12 I constructed and expressed different CDK12 mutants in insect cells and in mammalian cells. Also to investigate the role of the CDK12 mutants and the protein-protein interactions of CDK13 in alternative splicing, I also developed a PCR based E1A mini-gene splicing assay.
Development of Harmaline-induced Tremor in a Swine Model
Creators: name: Lee, Jihyun
name: Kim, Inyong
name: Lee, Jeyeon
name: Knight, Emily
name: Cheng, Lei
name: Kang, Shin Il
name: Jang, Dong Pyo
name: Chang, Su-Youne
Publisher: name: Columbia University
Year: 2018
Subjects: subject: Tremor
subject: Accelerometers
subject: Diseases--Animal models
subject: Neurosciences
subject: FOS: Clinical medicine

description: Background: In the field of translational neuroscience research, it is critical to utilize a large animal model to test the feasibility, safety, and functionality of novel therapies. Here, we describe a protocol for the development of a large animal model of tremor.

Methods: In a pig model, tremor was induced with harmaline and measured with wireless accelerometers attached to the limbs. Three different doses of harmaline were tested and three repetitive injections were made at 72-hour intervals. To fully characterize the drug-induced tremor, onset time, tremor amplitude, maintained duration, and peak tremor frequency were analyzed.

Results: Harmaline-induced tremor appeared immediately following intravenous injection of harmaline. Tremor was maintained over 2 hours. Its frequency was 10–16 Hz, which was independent of doses. Dose-dependent responses were observed in tremor amplitude, triggering time, and tremor-maintained duration. Repetitive injection of harmaline desensitized the harmaline effect.

Discussion: We provide a detailed protocol for training, drug injection, device selection, and tremor recording optimized to create a swine model of tremor with harmaline. Our protocol provides reliable tremor in pigs and suggests pig as a valid translational large animal model of tremor.
Gauge Invariant Two-Photon-Exchange Contributions in $e^-π^+ \rightarrow e^-π^+$
Creators: name: Zhou, Hai Qing
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The gauge invariant two-photon exchange (TPE) contributions in $e^-π^+ \rightarrow e^-π^+$ are discussed at hadronic level. The contact term is added to keep the full amplitude gauge invariant by two methods: one is to multiply form factors with the point-like particles scattering amplitude and another is to construct a gauge invariant Lagangian. The practical calculations show the TPE corrections by these two methods are almost the same, while the later method is favored when extending the discussion to processes including two charged finite-size particles like $ep \rightarrow enπ^+$.
description: 5 pages, 2 fugures
Advances in Treatment of Wilson Disease
Creators: name: Aggarwal, Annu
name: Bhatt, Mohit
Publisher: name: Columbia University
Year: 2018
Subjects: subject: Hepatolenticular degeneration
subject: Neurosciences
subject: FOS: Clinical medicine
subject: Penicillamine
subject: Neurology
subject: Medicine

description: Background: Wilson disease (WD) is an inherited neurometabolic disorder that results in excessive copper deposition in the liver and the brain, affecting children and young adults. Without treatment the disease is invariably fatal. Though treatments for WD have been available since the 1950s, the disease continues to be associated with considerable morbidity and mortality because of missed diagnosis, and delayed or inadequate treatment. In this paper we survey WD-related literature in order to review recent advances in WD treatment.

Methods: We performed a literature search using the PubMed database for articles relating to WD and its medical treatment. We reviewed the articles, and cross-references of relevant articles, to summarize the current practices for treatment of WD.

Results: The survey shows that if WD is properly treated, in most patients the liver can be stabilized, even severe neurological disability reversed, and patients can resume normal lives.

Discussion: Medical treatment for WD includes use of copper chelators (penicillamine, trientine, dimercaprol, dimercaptopropane sulfonate, and ammonium tetrathiomolybdate) and drugs that decrease gastrointestinal copper absorption. Our knowledge of the treatment approaches has benefited from the large systematic clinical studies that have been conducted over the last decade. For each drug used to treat WD, we surveyed its development, indication for use, dosing, efficacy, and adverse effects.
Misplaced Faith? Medieval Pottery and Fieldwalking
Creators: name: Gerrard, Christopher M
Publisher: name: Archaeology Data Service
Year: 2023

description: Medieval Ceramics: Journal of the Medieval Ceramics Research Group, 21, 61-72
description: The Shapwick project, Somerset, began in 1989 as a ten-year, multi-disciplinary landscape investigation focused particularly upon the evolution of early and late medieval settlement patterns. One of the aims of the project is to examine appropriate methodologies for the investigation of rural historic landscapes. This paper considers the efficacy of fieldwalking as a means of identifying archaeological monuments and land-use for the medieval period.
Reactivity under cover in controlled Near Ambient Pressure conditions: CO on bare and graphene covered NI(111)
Creators: name: DAVI', ROCCO
Publisher: name: Universit� degli studi di Genova
Year: 2022

description: The graphene?metal interface, as an interesting graphene-based system, attracts much attention from both the application and the fundamental science points of view. One of the reasons is that Chemical Vapor Deposition (CVD) on metal surfaces is the most promising method to produce large area graphene sheets with nickel and copper as most frequently used substrates. However, Ni has a severe drawback due to the high solubility of carbon at the temperatures required for CVD (>800 K). Dissolved carbon atoms may segregate to the surface of the substrate while cooling down the system, producing unwanted graphene multilayer structures. Careful preparation protocols have therefore to be followed, which leave carbide traces on the surface which can absorb the segregating carbon atoms by transforming into graphene. Another reason is that the graphene properties may be strongly affected by the interaction with the substrate, thus yielding interesting catalytic properties. My thesis is focused on the interaction of CO with Ni(111) which I studied in operando conditions with Near Ambient Pressure by X-Ray Photoemission Spectroscopy (NAP-XPS) at ~ 3 mbar thus extending the so far explored pressure range by nearly one order of magnitude. Under these conditions I observed the detachment of the strongly interacting graphene and its conversion into weakly interacting graphene caused by CO intercalation under it already at 500 K. Intercalation of gases is important since it restores the Dirac cone and thus the exceptionally large carrier mobility of graphene and because chemical reactions may be favored under cover by the constrained volume. Indeed, above 600 K, formation of physisorbed CO2 is observed under the graphene cover, a process I ascribe to the onset of the Boudouard reaction. The latter leads to the formation of additional carbon atoms which transform the residual carbide, present at the surface, into graphene causing the expansion of the graphene islands. Furthermore, my data confirm that CO does not only intercalate, but adsorbs also above the strongly interacting graphene areas forming a weakly bonded species of possible catalytical relevance. The reaction has been observed also after drilling single and double vacancies into the graphene layer by ion bombardment. CO2 tends then to mend the vacancies forming a bridge over their borders.
Cheapish and Spanish: Meaning and Design on Imported Spanish Pottery
Creators: name: Guti�Rrez, Alejandra
Publisher: name: Archaeology Data Service
Year: 2023

description: Medieval Ceramics: Journal of the Medieval Ceramics Research Group, 21, 73-82
description: This paper considers the contention that the meaning of pottery is culturally specific and often transmutable. Taking the differing forms and decorative styles of imports of Spanish medieval pottery as an example, it is argued that the pots often had special meanings attached to them in the minds of the Mediterranean potters who originally produced them. This meaning was carried mainly in their specific colour and motifs of decoration and can only be explained by understanding the social setting of pottery production. Once imported into southern England these nuances were then lost on consumers of a different nationality and religion and the pots attained new significance, often said to relate to the reinforcement of social standing.
Ceramics and the History of Consumption: Pitfalls and Prospects
Creators: name: Courtney, Paul
Publisher: name: Archaeology Data Service
Year: 2023

description: Medieval Ceramics: Journal of the Medieval Ceramics Research Group, 21, 95-108
description: This article attempts to outline some of the main theoretical issues and practical achievements in the history of consumption. It does not attempt to offer a history of ceramic consumption but instead aims to raise a number of methodological and theoretical issues relevant to ceramic interpretation of the medieval and post-medieval periods.
Jan Emens Menneken Of Raeren: Auf der Pfau and Far Off?
Creators: name: Giertz, Wolfram
Publisher: name: Archaeology Data Service
Year: 2023

description: Medieval Ceramics: Journal of the Medieval Ceramics Research Group, 22-23, 113-123
description: In obscurity since its undocumented excavation from 1878-85, the probable workshop site of the master potter Jan Emens Menneken has recently been rediscovered at Raeren-Neudorf, Belgium. An assemblage of signed and dated waster sherds still remaining on site hints at Emens' activity there from at least 1566 until about 1586/87. The remarkable absence of any wasters assignable to his so-called late work of the period c1588-1593/94, the year of his alleged death at Raeren, is explained by Emens' possible emigration to the Westerwald region. Supported by archaeological data, art-historical and technological aspects and a reassessment of the archival records, it is suggested that Emens established several consecutive workshops in neighbouring Westerwald villages. Under the name of Johann Mennicken from Raeren, from 1588 until well into the 17th century, he hypothetically became influential in the development of Westerwald-style cobalt-blue stoneware.
Sustainable use of plants adapted to the Mediterranean climate as sources of bioactive compounds with health and environmental applications
Creators: name: BAZZICALUPO, MIRIAM
Publisher: name: Universit� degli studi di Genova
Year: 2021

description: This PhD project was focused on the identification of some species of Mediterranean climate to be used according to eco-sustainability criteria for the obtainment of bioactive compounds with health properties or with applications in the environmental field. Himantoglossum robertianum flowers and Carpobrotus edulis leaves were micromorphologically characterized and used to obtain an hydroalcoholic and an aqueous extract, respectively. These extracts were then analysed from the phytochemical point of view. In addition, antioxidant and anti-inflammatory properties, inhibitory activities against enzymes involved in the extracellular matrix degradation and in inflammations, and their cicatrizing abilities were evaluated. Tests were performed both by cell-free enzymatic techniques and using in vitro cell cultures. H. robertianum is a terrestrial epiphytic orchid that can reach up to 80 cm in height, commonly known as Giant orchid due to its showy inflorescence and its considerable dimensions. According to previous data, this species resulted rich orchicyanin I and II and serapianin, anthocyanins already used in cosmetic formulations. With this in mind and considering that the species is in progressive expansion along Mediterranean coasts, we used its flowers to obtain a hydro-alcoholic extract to be tested for biological properties. Since H. robertianum is a protected species, we also planned and optimized techniques for in vitro micropropagation of the plant. Concerning C. edulis, the Hottentot fig, it is highly cited in ethnobotanical surveys for the treatment of various ailments and skin affections. This plant is an alien invasive species now naturalized in the Mediterranean area to the detriment of indigenous flora, thus representing a serious environmental problem. The species is therefore subject to several and repeated eradication campaigns. In a perspective of circular economy and sustainable use of natural resources we decided to use the leaves material with the aim to evaluate the biological activity of an aqueous extract obtained from the leaves. Data collected support the use of C. edulis as a natural resource for skin care and confirm the advisability of using material removed from the natural environment for this purpose.
Finally, again concerning the sustainable use of resources, peels from three different species of Citrus spp, widely cultivated in Southern Italy, were employed for the obtainment of their essential oils. Peels nowadays represent a consistent by-product of the citrus industry. Sites of production of bioactive compounds were morphologically characterised and essential oils obtained were evaluated from the phytochemical point of view. Essential oils were then tested for their phytotoxic activity against weeds and for their potential use as bioherbicides
Reversal of Status Dystonicus after Relocation of Pallidal Electrodes in DYT6 Generalized Dystonia
Creators: name: Oterdoom, D. L. Marinus
name: Van Egmond, Martje E.
name: Ascencao, Luisa Cassini
name: Van Dijk, J. Marc C.
name: Saryyeva, Assel
name: Beudel, Martijn
name: Runge, Joachim
name: De Koning, Tom J.
name: Abdallat, Mahmoud
name: Eggink, Hendriekje
name: Tijssen, Marina A. J.
name: Krauss, Joachim K.
Publisher: name: Columbia University
Year: 2018
Subjects: subject: Brain stimulation
subject: Dystonia
subject: Neurology
subject: Neurosciences
subject: FOS: Clinical medicine

description: Background: DYT6 dystonia can have an unpredictable clinical course and the result of deep brain stimulation (DBS) of the internal part of the globus pallidus (GPi) is known to be less robust than in other forms of autosomal dominant dystonia. Patients who had previous stereotactic surgery with insufficient clinical benefit form a particular challenge with very limited other treatment options available.

Case Report: A pediatric DYT6 patient unexpectedly deteriorated to status dystonicus 1 year after GPi DBS implantation with good initial clinical response. After repositioning the DBS electrodes the status dystonicus resolved.

Discussion: This case study demonstrates that medication-resistant status dystonicus in DYT6 dystonia can be reversed by relocation of pallidal electrodes. This case highlights that repositioning of DBS electrodes may be considered in patients with status dystonicus, especially when the electrode position is not optimal, even after an initial clinical response to DBS.
A Late Saxon Pottery Industry in Staffordshire: A Review
Creators: name: Ford, Debbie D
Publisher: name: Archaeology Data Service
Year: 2023

description: Medieval Ceramics: Journal of the Medieval Ceramics Research Group, 22-23, 11-36
description: This paper is a review of pottery production in Staffordshire during the late 9th- to 11th-century. It is based on a lecture given at the Medieval Pottery Research Group conference in London in May 1998. Within Staffordshire the main type of pottery of the Late Saxon period is Stafford-type ware. Stafford is the only place where evidence for its production has been found - almost a metric tonne of pottery and the remains of four kilns and their associated pits and structures. However, Stafford-type ware was first characterised in Chester, and is known by other names: Chester ware, Chester-type ware, Stafford ware and West Midlands early medieval ware. The variety of names may cause confusion and it has never been confirmed that they all apply to pottery made at the same production source. These issues are not addressed here. Until the industry has been fully researched archaeologists should be wary of applying undue significance to the identification and dating of a Stafford-type/Chester-type/West Midlands early medieval sherd. The pottery produced in Stafford has a sandy, hard-fired fabric. Small jars and bowls with convex bases were the main forms. Large jars, pedestal cups, lamps and bowls with socketed handles also occur. The vessels show a range of techniques of manufacture and finish; some are decorated. Stafford-type ware was well-made, but there are variations in quality and finish.
Metaheuristic based Peer Rewiring for Semantic Overlay Networks
Creators: name: YANG, YULIAN
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: A Peer-to-Peer (P2P) platform is considered for collaborative Information Retrieval (IR). Each peer hosts a collection of text documents with subjects related to its owner's interests. Without a global indexing mechanism, peers locally index their documents, and provide the service to answer queries. A decentralized protocol is designed, enabling the peers to collaboratively forward queries from the initiator to the peers with relevant documents.

Semantic Overlay Network (SON) is one of the state-of-the-art solutions, where peers with semantically similar resources are clustered. IR can then be efficiently performed by forwarding queries to the relevant peer clusters in an informed way. SONs are built and maintained mainly via peer rewiring. Specifically, each peer periodically sends walkers to its neighborhood. The walkers walk along peer connections, aiming at discovering more similar peers to replace less similar neighbors of its initiator. The P2P network hence gradually evolves from a random overlay network to a SON.

Random and greedy walk can be applied individually or integrated in peer rewiring as a constant strategy during the progress of network evolution. However, the evolution of the network topology may affect their performance. For example, when peers are randomly connected with each other, random walk performs better than greedy walk for exploring similar peers. But as peer clusters gradually emerge in the network, a walker can explore more similar peers by following a greedy strategy. This thesis proposes an evolving walking strategy based on Simulated Annealing (SA), which evolves from a random walk to a greedy walk along the progress of network evolution. According to the simulation results, SA-based strategy outperforms current approaches, both in the efficiency to build a SON and the effectiveness of the subsequent IR.

This thesis contains several advancements with respect to the state-of-the-art in this field. First of all, we identify a generic peer rewiring pattern and formalize it as a three-step procedure. Our technique provides a consistent framework for peer rewiring, while allowing enough flexibility for the users/designers to specify its properties. Secondly, we formalize SON construction as a combinatorial optimization problem, with peer rewiring as its decentralized local search solution. Based on this model, we propose a novel SA-based approach to peer rewiring. Our approach is validated via an extensive experimental study on the effect of network rewiring on (i) SON building and (ii) IR in SONs.
Reduction and Oxidation in English Medieval Kiln Practice
Creators: name: Newell, RW
Publisher: name: Archaeology Data Service
Year: 2023

description: Medieval Ceramics: Journal of the Medieval Ceramics Research Group, 22-23, 124-134
description: Although the effects of reduction and oxidation on medieval pottery are easily recognized, the technical means of producing them are less well understood. The present paper will look at some aspects of body and glaze reduction and reduction firing in open-topped kilns. Grimston reduced glazed pottery, medieval unglazed greywares and Cheam whitewares will serve as illustrative examples.
The impact of CD45 on dendritic cell activation and tolerogenic response
Creators: name: Boyce, Guilaine
Publisher: name: University of British Columbia
Year: 2012

description: Dendritic cells (DCs) are potent antigen presenting cells that orchestrate the immune system to mediate either a pro- or anti-inflammatory response, by provision of critical instructive signals to T cells. The leukocyte-specific tyrosine phosphatase CD45 can influence the immune response by its ability to act as either a positive or negative regulator of DC pro-inflammatory cytokine production. This dissertation explores the effect of CD45 in mediating a tolerogenic response in DCs. The lack of CD45 in bone marrow derived dendritic cells (BMDCs) was found to cause a preferential production of IL-10 in response to LPS stimulation, despite the mature DC phenotype defined by elevated expression levels of MHCII and co-stimulatory molecules CD80 and CD86, and the unaffected ability of CD45 deficient BMDCs to drive naïve CD4⁺ T cells or CD4⁺ Foxp3⁺ regulatory T cell (Treg) proliferation in vitro. An important in vivo finding was that CD45 deficiency in RAG-/- mice provided greater protection against wasting disease in the Treg mediated prevention of experimental colitis. This survival advantage was found to correlate with an increased proportion of Tregs at the colonic lamina propria in CD45 deficient RAG-/- mice. Culture of BMDC precursors with the anti CD45RB antibody generated BMDCs with reduced LPS-induced IL-12 production and T cell stimulatory capacity implicating CD45RB expression in the promotion of tolerogenic responses in DCs. Rapamycin, a pharmacological inhibitor of the mTOR pathway, was found to have a minimal effect on inducing a tolerogenic DC from BMDCs generated by culture in GM-CSF alone. However rapamycin exhibited a more profound suppressive effect on the ability of CD45 deficient DCs to drive T cell proliferation in vitro. Overall this study suggests that the CD45RB isoform may specifically inhibit an inflammatory response in DCs but the loss of all CD45 isoforms in DCs may potentially mediate T tolerance through immune deviation, while the loss of CD45 in multiple innate immune cells may culminate in an environment that promotes Treg expansion or function in vivo.
Additional file 1 of A review on the application of the exposome paradigm to unveil the environmental determinants of age-related diseases
Creators: name: Ding, Enmin
name: Wang, Yu
name: Liu, Juan
name: Tang, Song
name: Shi, Xiaoming
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Computational Biology

description: Additional file 1. The search strategies and main results of epidemiologic studies reporting the association between environmentalrisk factors and age-related diseases.
Synthesis of novel quinolines, pyrrolo[2,3-b]indoles, and 1H-pyrimido[4,5-b]indole-2,4(3H,9H)-diones via palladium-catalyzed cross-coupling reactions
Creators: name: Cherevatenko, Maksym
Publisher: name: Universität Rostock
Year: 2017
Subjects: subject: 540 Chemistry & allied sciences

description: The present thesis is mainly dedicated to the study of the synthesis of quinolines, pyrolo[2,3-b]indoles and 1H-pyrimido[4,5-b]indole-2,4(3H,9H)-diones via palladium-catalyzed cross-coupling reactions. This includes arylation of quinolines via Suzuki-Miyaura and alkynylation of 4-trifluoromethylquinolines via Sonogashira reaction. Consequent synthesis of a wide range of fused pyridines and their further modifications were successfully performed. A number of pyrolo[2,3-b]indoles and pyrimido[4,5-b]indole-2,4(3H,9H)-diones were synthesized with the usage of Buchwald-Hartwig reaction.
Spinocerebellar Ataxia 27: A Review and Characterization of an Evolving Phenotype
Creators: name: Groth, Christopher L.
name: Berman, Brian D.
Publisher: name: Columbia University
Year: 2018
Subjects: Ataxia
Friedreich's ataxia
Movement disorders
Tremor
Neurology

description: Background: Spinocerebellar ataxia (SCA) is an uncommon form of progressive cerebellar ataxia with multiple genetic causes and marked variability in phenotypic expression even across patients with identical genetic abnormalities. SCA27 is a recently identified SCA caused by mutations in the Fibroblast Growth Factor 14 gene, with a phenotypic expression that is only beginning to be fully appreciated. We report here a case of a 70-year-old male who presented with slowly worsening tremor and gait instability that began in his early adulthood along with additional features of parkinsonism on examination. Work-up revealed a novel pathogenic mutation in the Fibroblast Growth Factor 14 gene, and symptoms improved with amantadine and levodopa. We also provide a review of the literature in order to better characterize the phenotypic expression of this uncommon condition.

Methods: Case report and review of the literature.

Results: Review of the literature revealed a total of 32 previously reported clinical cases of SCA27. Including our case, we found that early-onset tremor (12.1 ± 10.5 years) was present in 95.8%, while gait ataxia tended to present later in life (23.7 ± 16.7 years) and was accompanied by limb ataxia, dysarthria, and nystagmus. Other features of SCA27 that may distinguish it from other SCAs include the potential for episodic ataxia, accompanying psychiatric symptoms, and cognitive impairment.

Discussion: Testing for SCA27 should be considered in individuals with ataxia who report tremor as an initial or early symptom, as well as those with additional findings of episodic ataxia, neuropsychiatric symptoms, or parkinsonism.
Quantum Factum Number Transform (QFNT) – Spectral Semantics Framework
Creators: name: Bollwahn, Jörg
name: Bollwahn, Jörg
Publisher: name: Zenodo
Year: 2025
Subjects: qfnt, spectral semantics, zeta function, operator theory, subtext, resonance, emotion, truth, topos

description: QFNT – Quantum Factum Number Transform & Spectral Semantics Framework

The QFNT model treats statements not as binary true/false propositions but as spectral objects with their own operator structures. Using Zeta-functions, eigenvalue analyses, and semantic potential fields, it reveals a measurable landscape of truth and meaning. This ZIP includes the LaTeX source of the QFNT manifesto, Zeta resonance visualizations, and the formal discipline document Spectral Semantics.
Towards hydrodynamics without an entropy current
Creators: name: Jensen, Kristan
name: Kaminski, Matthias
name: Kovtun, Pavel
name: Meyer, Rene
name: Ritz, Adam
name: Yarom, Amos
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We present a generating functional which describes the equilibrium thermodynamic response of a relativistic system to external sources. A variational principle gives rise to constraints on the response parameters of relativistic hydrodynamics without making use of an entropy current. Our method reproduces and extends results available in the literature. It also provides a technique for efficiently computing n-point zero-frequency hydrodynamic correlation functions without the need to solve the equations of hydrodynamics.
description: 4+epsilon pages, v2: comments and references added
Minimum Standards: Sampling and Statistics
Creators: name: Orton, Clive
Publisher: name: Archaeology Data Service
Year: 2023

description: Medieval Ceramics: Journal of the Medieval Ceramics Research Group, 22-23, 135-138
description: The purpose of statistics is to detect and/or verify patterns in data, and to suggest possible sources of such patterns. Interpretation of patterns so revealed is a matter for archaeological theory. Standards are needed to ensure that interpretations are based on patterns that exist at the level at which the interpretation is to be made (for example, comparison of assemblages in use at a locus; or the effects of site formation processes). The purpose of sampling is to reduce the cost (time, money or opportunity cost) of detecting and/or verifying such patterns. Standards are needed to ensure that the process does not (a) reduce the evidence to a level at which it is not safe to interpret, (b) introduce spurious patterns, or (c) result in redundant effort.
Minimum Standards for Quantifying Pottery
Creators: name: Arecelin, Patrice
name: Tuffreau-Libre, Marie
Publisher: name: Archaeology Data Service
Year: 2023

description: Medieval Ceramics: Journal of the Medieval Ceramics Research Group, 22-23, 139-144
description: This paper presents a summary of the results recently published of a national conference which was held in France, in Mont-Beuvray, in April 1998. The aim of this conference was to discuss the different methods used for quantitative studies of pottery and to confront the methods used in contemporary studies. We needed a common method which would be accepted by most archaeologists, which was scientifically as sound as possible, and which would also be the simplest, the most efficient, and the least time-consuming. This approach is not new. It is simply the adoption of minimum common standards to permit relevant comparisons between different regions, periods and settlements.
Numerical simulation of time delay interferometry for eLISA/NGO
Creators: name: Wang, Gang
name: Ni, Wei-Tou
Publisher: name: arXiv
Year: 2012
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: eLISA/NGO is a new gravitational wave detection proposal with arm length of 10^6 km and one interferometer down-scaled from LISA. Just like LISA and ASTROD-GW, in order to attain the requisite sensitivity for eLISA/NGO, laser frequency noise must be suppressed to below the secondary noises such as the optical path noise, acceleration noise etc. In previous papers, we have performed the numerical simulation of the time delay interferometry (TDI) for LISA and ASTROD-GW with one arm dysfunctional by using the CGC 2.7 ephemeris. The results are well below their respective limits which the laser frequency noise is required to be suppressed. In this paper, we follow the same procedure to simulate the time delay interferometry numerically. To do this, we work out a set of 1000-day optimized mission orbits of the eLISA/NGO spacecraft starting at January 1st, 2021 using the CGC 2.7 ephemeris framework. We then use the numerical method to calculate the residual optical path differences in the second-generation TDI solutions as in our previous papers. The maximum path length difference, for all configurations calculated, is below 13 mm (43 ps). It is well below the limit which the laser frequency noise is required to be suppressed for eLISA/NGO. We compare and discuss the resulting differences due to the different arm lengths for various mission proposals -- eLISA/NGO, an NGO-LISA-type mission with a nominal arm length of 2 x 10^6 km, LISA and ASTROD-GW.
description: 17 pages, 13 figures, 3 tables, minor changes in description to match the accepted version of Classical and Quantum Gravity. arXiv admin note: text overlap with arXiv:1102.4965
Action diffusion and lifetimes of quasistationary states in the Hamiltonian Mean Field model
Creators: name: Ettoumi, Wahb
name: Firpo, Marie-Christine
Publisher: name: arXiv
Year: 2012
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: Out-of-equilibrium quasistationary states (QSSs) are one of the signatures of a broken ergodicity in long-range interacting systems. For the widely studied Hamiltonian Mean-Field model, the lifetime of some QSSs has been shown to diverge with the number N of degrees of freedom with a puzzling N^1.7 scaling law, contradicting the otherwise widespread N scaling law. It is shown here that this peculiar scaling arises from the locality properties of the dynamics captured through the computation of the diffusion coefficient in terms of the action variable. The use of a mean first passage time approach proves to be successful in explaining the non-trivial scaling at stake here, and sheds some light on another case, where lifetimes diverging as e^N above some critical energy have been reported.
The Development of a Glucose Enzyme Electrode
Creators: name: Roulston, Simon
Publisher: name: London South Bank University
Year: 1991

description: An investigation has been undertaken into the suitability of sulphanilic acid carbons as electrode materials and as enzyme electrode materials specifically. The carbons, prepared at a range of heat treatment temperatures between 700k and 1400K have been characterised for their physical and chemical characteristics, with particular emphasis on electrical and surface functional group phenomena. The work has lead to an understanding of the carbonisation behaviour of the sulphanilic acid carbons and to a partial structural elucidation. The carbons are shown to be amorphous semiconductors, incorporating carbon, hydrogen, nitrogen, sulphur and oxygen, the oxygen moiety being associated with acidic surface oxides. The electrical conductivity mechanisms of these carbons have been shown to be explained by the Mott and Davis model for semiconduction in amorphous materials. The overall structural data is consistent with the recently proposed spheroidal carbon networks (Kroto et al, 1986). The carbons have been incorporated into an electrode assembly and electrochemical investigations undertaken. Electrodes formed from sulphanilic acid carbons prepared at 1400K have beem shown to respond potentiometrically to solution pH with approximately Nernstian behaviour. Cyclic voltammetric studies have been performed in several solutions and in the presence of two redox couples. The Fe(CN)se-4/Fe(CN)e-3 couple has been shown to behave in accordance with the Erev mechanism for electron transfer, by both classical cyclic voltammetric interpretation and by convolution potential sweep voltammetry. This behaviour is of interest due to the lack of electrode surface preparation employed. The 1400K sulphanilic acid carbon electrode has also been used as the basis of an amperometric enzyme electrode. The electrodes, employing covalently immobilised glucose oxidase, have been shown to be capable of quantitative glucose measurement through monitoring electrochemical peroxide decomposition. Certain other parameters such as_ pH, temperature and mediator influences have also been studied.
Holographic baryonic matter in a background magnetic field
Creators: name: Preis, Florian
name: Rebhan, Anton
name: Schmitt, Andreas
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We discuss the effect of baryonic matter on the zero-temperature chiral phase transition at finite chemical potential in the presence of a background magnetic field. The main part of our study is done in the deconfined geometry of the Sakai-Sugimoto model, i.e., at large N_c and strong coupling, with non-antipodal separation of the flavor branes. We find that for not too large magnetic fields baryonic matter completely removes the chiral phase transition: chirally broken matter persists up to arbitrarily large chemical potential. At sufficiently large magnetic fields, baryonic matter becomes disfavored and mesonic matter is directly superseded by quark matter. In order to discuss the possible relevance of our results to QCD, we compute the baryon onset in a relativistic mean-field model including the anomalous magnetic moment and point out the differences to our holographic calculation.
description: 29 pages, 8 figures, v2: references added, minor reformulations in the text, version accepted for publication in Journal of Physics G
Fast chemical reaction in two-dimensional Navier-Stokes flow: Initial regime
Creators: name: Ait-Chaalal, Farid
name: Bourqui, Michel S.
name: Bartello, Peter
Publisher: name: arXiv
Year: 2011
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: Atmospheric and Oceanic Physics (physics.ao-ph)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: This paper studies an infinitely fast bimolecular chemical reaction in a two-dimensional bi-periodic Navier-Stokes flow. The reactants in stoichiometric quantities are initially segregated by infinite gradients. The focus is placed on the initial stage of the reaction characterized by a well-defined one dimensional material contact line between the reactants. Particular attention is given to the effect of the diffusion of the reactants. This study is an idealized framework for isentropic mixing in the lower stratosphere and is motivated by the need to better understand the effect of resolutionon stratospheric chemistry in Climate-Chemistry Models. Adopting a Lagrangian stretching theory approach, we relate theoretically the ensemble mean of the length of the contact line, of the gradients along it and of the modulus of the rate of decrease of the space averaged reactant concentrations (here called the chemical speed) to the joint statistics of the finite time Lyapunov exponent with two equivalent times. The inverse of the Lyapunov exponent measures the stretching time scale of a Lagrangian parcel on a chaotic orbit up to a finite time t, while the first equivalent time measures it in the recent past before t and the second equivalent time in the early part of the trajectory. We show that the chemical speed scales like the square root of the diffusion and that its time evolution is determined by rare large events in the finite time Lyapunov exponent distribution. The case of smooth initial gradients is also discussed. The theoretical results are tested with an ensemble of direct numerical simulations (DNS) using a pseudospectral model.
description: 15 pages, 10 figures. Accepted for publication in Physical Review E (http://pre.aps.org/accepted/E/4c07aRb7Sff16f0618ba7d2105ec643d3613ad040). High resolution figures available upon request
PartArt4OW Interactive Stakeholder Map
Creators: name: Hadjimichael, Maria
name: Filippou, Rena
Publisher: name: Zenodo
Year: 2025

description: The D4.1 Interactive Stakeholder Map describes the digital social mapping of existing research activities, projects, and initiatives in Europe, combining art, science, and participation for the Ocean and Water. This digital environment is created using FirstLife platform, a geolocated civic social network developed by the University of Turin, offering an open access and open-source digital space. This document describes the process that facilitated the creation of the Map. The actual map is available at the following link:

https://partart4ow.firstlife.org/

This deliverable is licensed under a Creative Commons Attribution 4.0 International License (CC BY NCSA 4.0). You are free to share and adapt this material, provided appropriate credit is given. For full details, visit https://creativecommons.org/licenses/by-nc-sa/4.0/.