cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Development of hybrid platforms for antibody manufacturing optimisation
Creators: name: Barbosa, Rodrigo
Publisher: name: Imperial College London
Year: 2021

description: The clinical and commercial success of cell-derived proteins has generated significant research interest in the optimisation of their manufacturing processes. A focal point has been the upstream cultivation of mammalian cells for recombinant glycoprotein production, such as monoclonal antibodies (mAbs) (Oliveira et al., 2015), with optimisation options involving genetic/host engineering, media/feed formulation, and operating strategy. At a cellular level, such optimisation is carried out by harnessing the understanding of the genomic-phenotypic relationship. Despite many decades of scientific development, such efforts can often be time-consuming and resourceful expensive. In response to the increased development of optimisation strategies and manufacturing control, in silico models have been developed in the form of mathematical representations of physiological processes, in a quantifiable extension of controlled experimental conditions. They are employed to facilitate in-depth understanding of the underlying cellular physiology, be it in organising generated information from omics analysis or gaining insight about component interactions in complex systems. Nevertheless, mechanistic models, such as kinetic cell culture models, are typically rigid in their structure and contain parameters with set values, such as Monod constants for growth rate calculation and yields of metabolic pathways. The present thesis aims to explore hybrid modelling formulations, involving stoichiometric and kinetic models to create an adaptive modelling framework for cell metabolism. The principal motivation for developing the methodology was to formulate a segregated model informed by the stoichiometric metabolic model that could be fitted to a particular dataset and validated on experimental datasets from a series of platform process combinations. Additionally, machine learning algorithms were integrated with metabolic data analysis using stoichiometric models to identify extracellular and intracellular metabolic patterns that could correlate with productivity and growth. These can, in turn, be used to support cell line screening and selection protocols. Finally, the hybrid methodology has also been used to define feature-class decision boundaries for the system at hand, which can guide future process optimisation research via the identification of cellular constraints.
Additional file 1 of IL-6 from cerebrospinal fluid causes widespread pain via STAT3-mediated astrocytosis in chronic constriction injury of the infraorbital nerve
Creators: name: Yu, Ning
name: Cui, Huan
name: Jin, Sixuan
name: Liu, Penghao
name: Fang, Yehong
name: Sun, Fengrun
name: Cao, Yan
name: Yuan, Bo
name: Xie, Yikuan
name: Duan, Wanru
name: Ma, Chao
Publisher: name: figshare
Year: 2024
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mental Health
subject: Plant Biology

description: Additional file 1: Fig. S1. I.c. injection of IL-6 induced orofacial pain and widespread pain. A The workflow for i.c. injection of IL-6 for naïve rats. B-D The mechanical escape withdrawal threshold of vibrissal pad (B), the paw thermal withdrawal latency (C), and the paw mechanical withdrawal threshold (D) in rats receiving IL-6 (1.0 μg), IL-6 (5.0 μg) or vehicle. Two-way ANOVA, *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001, n = 7/group. Fig. S2. Neutralizing IL-6 inhibited the acitvation and proliferation of astrocytes. Immunofluorescence staining of C3 (A-B), Ki67 (C-D), and p-STAT3 (E-F) in primary cultured astrocytes after incubation of CCI-ION's CSF with IL-6 antibody or isotype IgG, along with quantitative analysis. t test, ***p<0.001, ****p<0.0001, n = 9/group. Scale bar: 75 µm.
Anarchism (Elgar Encyclopedia of Political Sociology)
Creators: name: Williams, Dana
Publisher: name: Edward Elgar Publishing
Year: 2023
Subjects: subject: Anarchists
subject: Protest movements
subject: Political science
subject: FOS: Political science
subject: Anarchism

description: Anarchism is a set of ideas and practices focused upon the elimination of hierarchies (political, economic, social), and prioritizes creating horizontal, self-managing, cooperative, egalitarian, and empowered communities. Anarchist movements have been active since the mid-Nineteenth century and have pursued insurrectionary, mass-organizing, and cultural strategies. Anarchist analyses of power argue the state and other hierarchical institutions have a colonizing influence upon people's lives and communities. In their place, anarchist organizations affirm direct democracy and federated tactics in place of states. Political sociology has found ways to study anti-authoritarian movements like anarchism, but their uniqueness presents epistemological and theoretical challenges, since most sociological scholarship has focused upon non-radical movements. Finally, an inter-disciplinary field called anarchist studies has incorporated sociology and other disciplines, most notably with a hybrid approach to social analysis called anarchist sociology, that prioritizes an anarchist lens.
sj-docx-1-anp-10.1177_00048674211009608 – Supplemental material for Hospital-treated deliberate self-poisoning patients: Drug-induced delirium and clinical outcomes
Creators: name: Gale, Lindsay
name: McGill, Katie
name: Twaddell, Scott
name: Whyte, Ian M
name: Lewin, Terry J
name: Carter, Gregory L
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: Neuroscience

description: Supplemental material, sj-docx-1-anp-10.1177_00048674211009608 for Hospital-treated deliberate self-poisoning patients: Drug-induced delirium and clinical outcomes by Lindsay Gale, Katie McGill, Scott Twaddell, Ian M Whyte, Terry J Lewin and Gregory L Carter in Australian & New Zealand Journal of Psychiatry
Additional file 7 of Radiation dose is associated with improved local control for large, but not small, hepatocellular carcinomas
Creators: name: Amit, Uri
name: Mohiuddin, Jahan J
name: Wojcieszynski, Andrzej P
name: Harton, Joanna
name: Williams, Graeme
name: Manjunath, Shwetha
name: Grandhi, Nikhil
name: Doucette, Abigail
name: Plastaras, John P
name: Metz, James M
name: Ben-Josef, Edgar
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Cancer

description: Supplementary Material 7
Patient Academy: empowering patients to self-manage chronic respiratory diseases
Creators: name: Smalley, Katelyn
Publisher: name: Imperial College London
Year: 2021

description: As long-term, chronic conditions comprise an increasingly large share of illness in the UK and globally, healthcare providers and policymakers must rely more heavily on patients assuming a larger role in their own care through self-management. Self-management is critical both in terms of patient safety and patient experience. While self-management programs are common, there is a lack of clarity around several issues: • What should patients be expected to do for themselves? o Are they capable of doing these things? o If not, can they be taught? o Should all patients achieve the same level of self-management ability? o If not, how should variation be accounted for and/or addressed? • Do self-management programmes teach those skills? o What effects do they have? o Can they be used to promote self-management behaviours? o Which outcomes are of primary importance? • Which aspects of disease management should remain the purview of healthcare professionals? Have these been clearly communicated to all sides? Using chronic respiratory disease as a case study, this thesis addresses these gaps in understanding through a mixed-methods study of self-management capabilities and behaviours. Using secondary analysis of published literature and routine health record data, it conceptualises self-management ability as distinct from patient activation or engagement. It finds that specifying and measuring self-management is key to any attempt to ‘empower’ patients to change their behaviour, and also to adequately evaluate such an endeavour. It then turns to the question of specifying and measuring self-management ability in respiratory diseases. Views of patients, clinicians, and policymakers were solicited through semi-structured interviews and online Delphi questionnaires, to derive an assessment tool to measure self-management ability for bronchiectasis. This work culminates in a blueprint for a comprehensive self-management programme, called the Patient Academy, to deliver self-management education and skills training tailored to the needs and abilities of individual patients.
sj-docx-1-anp-10.1177_00048674211009603 – Supplemental material for Patterns and predictors of trajectories for subjective quality of life in patients with early psychosis: Three-year follow-up of the randomized controlled trial on extended early intervention
Creators: name: Kam, Candice Tze Kwan
name: Chang, Wing Chung
name: Kwong, Vivian Wing Yan
name: Lau, Emily Sin Ki
name: Chan, Gloria Hoi Kei
name: Jim, Olivia Tsz Ting
name: Hui, Christy Lai Ming
name: Chan, Sherry Kit Wa
name: Lee, Edwin Ho Ming
name: Chen, Eric Yu Hai
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: Neuroscience

description: Supplemental material, sj-docx-1-anp-10.1177_00048674211009603 for Patterns and predictors of trajectories for subjective quality of life in patients with early psychosis: Three-year follow-up of the randomized controlled trial on extended early intervention by Candice Tze Kwan Kam, Wing Chung Chang, Vivian Wing Yan Kwong, Emily Sin Ki Lau, Gloria Hoi Kei Chan, Olivia Tsz Ting Jim, Christy Lai Ming Hui, Sherry Kit Wa Chan, Edwin Ho Ming Lee and Eric Yu Hai Chen in Australian & New Zealand Journal of Psychiatry
Argumentation, Metaphor, and Analogy: It's Like Something Else
Creators: name: Kramer, Chris A.
Publisher: name: Humanities Commons
Year: 2024
Subjects: subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: Logic
subject: Critical thinking
subject: Humor

description: A "good" arguer is like an architect with a penchant for civil and civic engineering. Such an arguer can design and present their reasons artfully about a variety of topics, as good architects do with a plenitude of structures and in various environments. Failures in this are rarely hidden for long, as poor constructions reveal themselves, often spectacularly, so collaboration among civical engineers can be seen as a virtue. Our logical virtues should be analogous. When our arguments fail due to being uncivil and demagogic, since we inhabit the arguments we build, we are all crushed beneath our flawed reasoning. This mixed metaphor takes us to a self-referential analysis of argumentation, analogy, and humor. I argue that good argumentation strives to collaboratively convince rather than belligerently persuade. A convincing means toward this end is through humorous analogical arguments, whether the matter at hand is ethical, logical, theological, phenomenological, epistemological, metaphysical, political, or about baseball.
Iron buckle and copper-alloy? plate
Creators: name: Hamerow, Helena
Publisher: name: University of Oxford
Year: 2021
Subjects: Archaeology

description: Iron buckle loop partly restored with plaster, iron tongue, and rectangular silver plate folded over loop, cut for tongue and edges of loop and secured by three rivets along bottom. Only two rivets survive, and these have sprung away from the front-plate.Mayer card merely attributes it to Sibertswold. The descriptions of buckles given by Faussett makes it clear that he made special descriptions of anything out of the ordinary, but that the simple buckle with rectangular plate, which was the norm, tended to be dismissed on the 'as before' formula. There is only one iron buckle with 'bronze' loop - silver when taken out of the grave can look like bronze - described from Sibertswold, and only one survives.
New Populism, New Conspiracism, and the Old Rhetoric of Purity
Creators: name: Kramer, Chris A.
Publisher: name: Humanities Commons
Year: 2023
Subjects: subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: Political science--Philosophy
subject: Propaganda

description: This entry investigates the connections between neo-populism and neo-conspiracism in the USA. One central thread is the rhetoric of purity that fosters rigid dichotomies of thought about identities, contributing to both populism and conspiracism, eliciting a neologism: conspirapopulism.
sj-pdf-1-usj-10.1177_00420980211006030 – Supplemental material for Citizenship acquisition and spatial stratification: Analysing immigrant residential mobility in the Netherlands
Creators: name: Leclerc, Christophe
name: Vink, Maarten
name: Schmeets, Hans
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law
subject: Economics
subject: Geography
subject: 160607 International Relations
subject: FOS: Political science
subject: Sociology
subject: FOS: Sociology
subject: 120599 Urban and Regional Planning not elsewhere classified
subject: FOS: Social and economic geography

description: Supplemental material, sj-pdf-1-usj-10.1177_00420980211006030 for Citizenship acquisition and spatial stratification: Analysing immigrant residential mobility in the Netherlands by Christophe Leclerc, Maarten Vink and Hans Schmeets in Urban Studies
Additional file 6 of Contralateral grafts have comparable efficacy to ipsilateral grafts in anterior cruciate ligament reconstructions: a systematic review
Creators: name: Fan, DingYuan
name: Ma, Jia
name: Zhang, Lei
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 6: Appendix Fig. S5. Isokinetic peak flexion torque of the hamstring (donor site group versus nonoperative group). CI, confidence intervals; IV, inverse variance; SD, standard deviation.
Additional file 3 of Contralateral grafts have comparable efficacy to ipsilateral grafts in anterior cruciate ligament reconstructions: a systematic review
Creators: name: Fan, DingYuan
name: Ma, Jia
name: Zhang, Lei
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 3: Appendix Fig. S2A. Forest plot showing the isometric strength of the flexion hamstring muscles (contralateral group versus ipsilateral group). CI, confidence intervals; IV, inverse variance; SD, standard deviation. Appendix Fig. 2B. Forest plot showing the isometric strength of the flexion hamstring muscles (donor site group versus ipsilateral group). CI, confidence intervals; IV, inverse variance; SD, standard deviation. Appendix Fig. 2C. Forest plot showing the isometric strength of the flexion hamstring muscles (donor site group versus nonoperative group). CI, confidence intervals; IV, inverse variance; SD, standard deviation.
Supplemental Material, sj-pdf-1-jsr-10.1177_10946705211012475 - The Mode Heuristic in Service Consumers’ Interpretations of Online Rating Distributions
Creators: name: Köcher, Sarah
name: Köcher, Sören
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business
subject: 150402 Hospitality Management

description: Supplemental Material, sj-pdf-1-jsr-10.1177_10946705211012475 for The Mode Heuristic in Service Consumers’ Interpretations of Online Rating Distributions by Sarah Köcher and Sören Köcher in Journal of Service Research
Supplemental Material, sj-docx-1-ijq-10.1177_16094069211012217 - A Guide to Conducting Online Focus Groups via Reddit
Creators: name: Richard, Brendan
name: Sivo, Stephen A.
name: Ford, Robert C.
name: Murphy, Jamie
name: Boote, David N.
name: Witta, Eleanor
name: Orlowski, Marissa
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111099 Nursing not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental Material, sj-docx-1-ijq-10.1177_16094069211012217 for A Guide to Conducting Online Focus Groups via Reddit by Brendan Richard, Stephen A. Sivo, Robert C. Ford, Jamie Murphy, David N. Boote, Eleanor Witta and Marissa Orlowski in International Journal of Qualitative Methods
The effects of Melanocortin-4 receptor agonism and kisspeptin on sexual brain processing in women with hypoactive sexual desire disorder
Creators: name: Hunjan, Tia
Publisher: name: Imperial College London
Year: 2021

description: Hypoactive sexual desire disorder (HSDD) is characterised by a persistent lack of sexual desire and sexual fantasies, causing marked interpersonal distress. It is the most common global female sexual health problem, although the precise pathophysiology remains uncertain. Existing treatment options are limited by their efficacy and side effects. Melanocortin-4 receptor (MC4R) agonists and kisspeptin provide promising therapeutic avenues. The MC4Ra, Bremelanotide, is licensed for the treatment of HSDD in premenopausal women in the USA, although the mechanism of action remains unknown. Kisspeptin is known to play a key role in regulating the hypothalamic-pituitary-gonadal (HPG) axis and recently, evidence for a role in sexual behaviour has emerged. Investigating the effects of MC4Ra and kisspeptin in women with HSDD and the neural pathways involved will deepen our knowledge of normal and abnormal sexual behaviour and provide information which could contribute to the development of novel treatment strategies for this condition. Using a combination of psychometric, neuroimaging and hormonal analyses, the role of MC4Ra and kisspeptin on sexual brain processing in premenopausal women with HSDD was investigated in two randomized, double-blind, placebo-controlled crossover trials. Both MC4Ra and kisspeptin enhanced sexual psychometric parameters. MC4Ra led to modulation of brain activity and changes in functional connectivity in response to erotic stimuli. Similarly, kisspeptin also led to modulation of brain activity in response to erotic stimuli, as well as enhancement of the perception of facial attractiveness and reduced sexual aversion. The brain regions impacted, provide a basis for the observed changes in psychometric parameters. These studies provide novel mechanistic insight for MC4Ra’s and kisspeptin’s effects on sexual desire in HSDD. These data also enhance our understanding of neural dysregulation in HSDD and have important and exciting implications for the future development of therapeutics for the treatment of HSDD.
sj-docx-4-eji-10.1177_20587392211016117 – Supplemental material for Atopy, asthma, and risk of bladder cancer: Systematic review and meta-analysis of cohort studies
Creators: name: Suoyi Feng
name: Ziqi Shao
name: Longzhu Ju
name: Yiting Zhang
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Medicine
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 111702 Aged Health Care
subject: 111403 Paediatrics
subject: FOS: Clinical medicine
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 110203 Respiratory Diseases
subject: 70706 Veterinary Medicine
subject: FOS: Veterinary sciences
subject: Cell Biology
subject: Biochemistry
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Supplemental material, sj-docx-4-eji-10.1177_20587392211016117 for Atopy, asthma, and risk of bladder cancer: Systematic review and meta-analysis of cohort studies by Suoyi Feng, Ziqi Shao, Longzhu Ju and Yiting Zhang in European Journal of Inflammation
Supplemental Material, sj-docx-2-jcr-10.1177_00220027211014937 - Anger, Anxiety, and Selective Exposure to Terrorist Violence
Creators: name: Huddy, Leonie
name: Smirnov, Oleg
name: Snider, Keren L. G.
name: Perliger, Arie
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 220104 Human Rights and Justice Issues
subject: FOS: Philosophy, ethics and religion
subject: 160607 International Relations
subject: FOS: Political science

description: Supplemental Material, sj-docx-2-jcr-10.1177_00220027211014937 for Anger, Anxiety, and Selective Exposure to Terrorist Violence by Leonie Huddy, Oleg Smirnov, Keren L. G. Snider and Arie Perliger in Journal of Conflict Resolution
Additional file 2 of Contralateral grafts have comparable efficacy to ipsilateral grafts in anterior cruciate ligament reconstructions: a systematic review
Creators: name: Fan, DingYuan
name: Ma, Jia
name: Zhang, Lei
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 2: Appendix Fig. S1A. Forest plot showing the isometric strength of the quadriceps muscles (contralateral group versus ipsilateral group). CI, confidence intervals; IV, inverse variance; SD, standard deviation. Appendix Fig. 1B. Forest plot showing the isometric strength of the quadriceps muscles. (Donor site group versus ipsilateral group). CI, confidence intervals; IV, inverse variance; SD, standard deviation.
Glass bead
Creators: name: Hamerow, Helena
Publisher: name: University of Oxford
Year: 2021
Subjects: Archaeology

description: Pale blue-green translucent glass ring-bead, with marvered trails, diam. 2.1cm. The green glass is very bubbly like the glass of 7th century vessels. The trail appears to have been made by means of a spiral rod of translucent green and opaque white, now discoloured to a fawn colour, so perhaps yellow. Anyway the opaque glass has badly weathered, compared for example with that on the similar bead M 6631 where the yellow is still good. The resulting diagonally striped trails have been applied round the hole on either side, and from the centres outwards in loops which touch or overlap on the edge of the bead.
Additional file 2 of A deep learning framework for accurate reaction prediction and its application on high-throughput experimentation data
Creators: name: Li, Baiqing
name: Su, Shimin
name: Zhu, Chan
name: Lin, Jie
name: Hu, Xinyue
name: Su, Lebin
name: Yu, Zhunzhun
name: Liao, Kuangbiao
name: Chen, Hongming
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Additional file 2. The supporting materials. It contains the details about the in-house HTE experimental process, model hyperparameters and model porformance.
Sport in Central Asia under Gorbachev: Uzbekistan (1985 to 1991)
Creators: name: Akyildiz, Sevket
Publisher: name: Humanities Commons
Year: 2021
Subjects: subject: Sports
subject: History
subject: Soviet Union
subject: Turkey
subject: Physical education and training
subject: Communism

description: This paper assesses the modern and traditional sports of the Soviet Union shortly before its collapse in 1991. The case study is the Central Asian republic of Uzbekistan under the Communist Party of the Soviet Union (CPSU, established 1917). Central Asia is a crucial historical case because it was a Muslim-majority region that Moscow wished to transform. The study is interdisciplinary and contains primary and secondary sources from the Cold War era. The research question asks: What did the implementation and impact of Soviet sport look like in Uzbekistan under Mikhail Gorbachev (CPSU leader from March 1985 to December 1991). Uzbekistan’s sportspeople, facilities, Spartakiad ranking of 1983, Olympic athletes, and traditional sports are the topics examined.
Glass bead or spindle whorl
Creators: name: Hamerow, Helena
Publisher: name: University of Oxford
Year: 2021
Subjects: Archaeology

description: Opaque black glass spindle whorl, decorated with marvered white trails, diam. 4cm. Base flat, low curved dome, central perforation made by glass-maker. The inlay is very deteriorated and may have been yellow. It consists of a curvaceous zig-zag trail around max. circumference, with just above it a thin girth trail; then a gap, then a group of 3-4 thin trails, with starting blob visible in one case, and untidy ends where the thread of opaque glass has been cut off and has fallen still hot across the glass. A further thick opaque trail of congealed set of trails around the hole.Roach Smith attributes this object to grave 30, but the original label says \S.Would 1773\" and grave 30 was excavated in 1772. The whorl does not fit the description for grave 30 anyway. Roach Smith made a careless mistake. Only grave 172 qualifies and only grave 172 had large 'earthen' disci. N.B. he [Faussett] always calls opaque glass 'earthen'."
PROFILAKTIKA INSPEKTORINING YASHASH MANZILLARIDAN UZOQ MUDDATGA KETGAN SHAXSLAR BO'YICHA ISHLASH FAOLIYATINI HUQUQIY TA'MINLASH
Creators: name: Tashtemirov, Anvar
name: Usmonova, Yulduz
Publisher: name: Zenodo
Year: 2024

description: O’tgan yillar davomida fuqarolarimizning uzoq muddatga chet elga chiqishlari va qaytib kelishlarini tartibga solishga qaratilgan bir qator normativ-huquqiy hujjatlarda qabul qilinib , ularning talablari jamiyat hayotga tatbiq etib kelinmoqda. Doimiy yashash manzillaridan uzoq muddatga uzoq muddatga ketgan shaxslarni aniqlash va ularga nisbatan amalga oshirilayotgan tezkor- profilaktik ishlar samaradorligini oshirish maqsadida hududiy ichki ishlar organlariga bir qator sharx, ko’rsatma va tavsiyalar doimiy ravioshda yuborib kelinayotganligiga qaramasdan, aksariyat ichki ishlar organlarida ushbu yo’nalishdagi ishlar talab darajasida yo’lga qo’yilmasdan qolmoqda.
Additional file 3 of Heme biosensor-guided in vivo pathway optimization and directed evolution for efficient biosynthesis of heme
Creators: name: Zhang, Jian
name: Li, Qingbin
name: Wang, Qi
name: Zhao, Jingyu
name: Zhu, Yuan
name: Su, Tianyuan
name: Qi, Qingsheng
name: Wang, Qian
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Computational Biology

description: Additional file 3: Table S3. Primers used in this study.
Blue-Action Project: Summary
Creators: name: Miller, Raeanne
Publisher: name: Zenodo
Year: 2017
Subjects: Arctic
climate change
climate challenges
climate impact
societal challenge
hazardous weather system
extreme events
Blue-Action
climate modelling
forecasting
blue growth

description: PDF presentation on the Blue-Action project (H2020)

WHY BLUE-ACTION?

Faced with a changing climate, businesses, policymakers, and local communities need to access reliable weather and climate information to safeguard human health, wellbeing, economic growth, and environmental sustainability

PROJECT SUMMARY

In response, Blue-Action aims to:

•improve our understanding of the impact of a changing Arctic on Northern Hemisphere weather and climate;

•improve the safety & wellbeing of people in the Arctic and across the Northern Hemisphere;

•reduce the risks associated with Arctic operations and resource exploitation; and,

•support evidence-based decision-making by policymakers worldwide.
description: We support the Blue Growth!
Visit us on: www.blue-action.eu
Follow us on Twitter: @BG10Blueaction
Glass bead
Creators: name: Hamerow, Helena
Publisher: name: University of Oxford
Year: 2021
Subjects: Archaeology

description: Opaque black glass spindle whorl or bead, diam 3.3cm, with decayed yellow or white marvered trailing. Base flat, top a truncated shallow cone; hole made by glass maker. A marvered trail around the edge (around maximum circumference) then irregular zig-zag trailing around top. One side badly damaged.
Chalk? bead
Creators: name: Hamerow, Helena
Publisher: name: University of Oxford
Year: 2021
Subjects: Archaeology

description: Large discoidal bead, apparently of puddled chalk, diam. 3.1cm, thickness 1cm, with large central hole. It is very light in weight, and where broken in one place the interior shows crumbly textured. The surface is smooth, though porous, and is stained brown on one side.
METHODS OF WORKING WITH A CHILDREN'S CHOIR
Creators: name: Jalilova, Kamolakhan
Publisher: name: Zenodo
Year: 2024

description: Music is a form of education. That is why in many countries of the world, children are taught the art of music. Choral, vocal and musical lessons are conducted for children in schools and in various clubs. Psychologists of the world also approve of this and say that it increases the child's mental activity, self-awareness and curiosity.
Pretargeted PET imaging of atherosclerosis with monoclonal antibodies against modified forms of low-density lipoproteins
Creators: name: Marceddu, Cinzia
Publisher: name: Imperial College London
Year: 2021

description: Oxidation of low-density lipoproteins (LDL) within the sub-intimal space leads to plaque formation, the underpinning pathophysiological mechanism of atherosclerotic cardiovascular diseases. Currently available positron emission tomography (PET) tracers for atherosclerosis target inflammation and are not specific for plaque. LO1 and LO9 are laboratory-developed antibodies capable of recognising LDL. Despite their high specificity, the use of full antibodies as PET tracers is limited due to their long circulation time, which may be overcome by pretargeted labelling. This requires trans-cyclooctene (TCO) conjugation to the antibody, followed by reaction with a radiolabelled tetrazine (Tz) in vivo, which is injected after the conjugated antibody has accumulated on target. Accordingly, Tz-NODA-Al[18F]F and [18F]FpyTz, were synthesised and radiolabelled with fluorine-18 and tested against TCO. In addition, a near-infrared fluorescence (NIRF) emitting tetrazine, Tz-VT and biotinylated Tz-biotin, were synthesised to mimic the behavior of the radiolabelled analogues for in vitro and ex vivo tests. LO9 and LO1 were conjugated to TCO via lysine residues to yield LO9-TCO and LO1-TCO, respectively. Next, enzyme-linked immunosorbent assays were performed to confirm retained function. Aortic sections from high fat-fed LDL receptor deficient (Ldlr-/-) mice were coated with LO9-TCO, LO9, LO1-TCO or LO1 and then exposed to NIR-VT; demonstrating reactivity between TCO-conjugated antibody and Tz-VT and retained antibody targeting. Next, Ldlr-/- mice fed a high-fat diet for 22 weeks were injected with either TCO-conjugated antibodies followed by the radiolabelled Tz after 72 hours, or directly labelled LO1-89Zr and LO9-89Zr, and imaged with PET/CT. Ex vivo biodistribution via ɣ-counting highlighted fast clearance of the Tz. At 30 minutes post-injection, only 3% of the injected activity was circulating, whilst 20% of the directly labelled antibody remained after 72 hours. Mice injected with LO1-89Zr and LO9-89Zr or TCO-conjugated antibodies showed greater aortic uptake than controls ex vivo. Preliminary visual analysis of in vivo PET imaging of pretargeted antibodies showed co-localisation of LO9 and LO1 at bifurcations of the aorta. In this study, we have successfully developed novel constructs for the first in vivo detection of atherosclerosis with pretargeted antibodies for PET.
Supplemental Material, sj-pdf-1-spr-10.1177_02654075211011704 - The longitudinal association between marital and psychological functioning in socioeconomically disadvantaged relationships
Creators: name: Kanter, Jeremy B.
name: Proulx, Christine M.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental Material, sj-pdf-1-spr-10.1177_02654075211011704 for The longitudinal association between marital and psychological functioning in socioeconomically disadvantaged relationships by Jeremy B. Kanter and Christine M. Proulx in Journal of Social and Personal Relationships
Additional file 4 of Heme biosensor-guided in vivo pathway optimization and directed evolution for efficient biosynthesis of heme
Creators: name: Zhang, Jian
name: Li, Qingbin
name: Wang, Qi
name: Zhao, Jingyu
name: Zhu, Yuan
name: Su, Tianyuan
name: Qi, Qingsheng
name: Wang, Qian
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Computational Biology

description: Additional file 4: Table S4. SH1–SH20 mutation.
ПРОБЛЕМИ АТРИБУЦІЇ МОНУМЕНТАЛЬНОГО ЖИВОПИСУ ЦЕРКВИ СПАСА НА БЕРЕСТОВІ В ІСТОРІОГРАФІЇ ХІХ–ХХІ СТ. (ISSUES OF ATTRIBUTION OF THE MONUMENTAL PAINTING OF THE CHURCH OF THE SAVIOR AT BERSETOVE IN THE HISTORIOGRAPHY OF THE 19th-21st CENTURIES)
Creators: name: Kondratiuk, Alina
Publisher: name: Humanities Commons
Year: 2022

description: The article examines the peculiarities of solving the issue of the attribution of the monumental painting of the Church of the Savior at Berestove in the domestic and foreign historiography of the 19th-21st centuries. The mural painting of the Church of the Savior at Berestove of 1643–1644, made by the efforts of Metropolitan Peter Mohyla, is the only full-preserved monumental ensemble of the post-Byzantine tradition on the territory of Ukraine. Characteristic features and contradictions of Ukrainian art of the first part of the 17th century were revealed in this ensemble. This is a polystylistic monument, which testifies to good familiarity of its creators with both the Byzantine tradition and the Western European Art. The mural painting is marked by an extremely high artistic level and have no analogues among Ukrainian monuments of that time. However, despite the constant interest of researchers in this monument for more than a century and a half, a number of scientific questions related to the monumental painting remain unsolved. Analysis of the literature and the source base of the research showed that the presence of several hypotheses regarding the artists-performers of the temple paintings of the era of Peter Mohyla does not allow us to consider the problem of attribution as solved. This issue requires further thorough study and new non-traditional approaches.
Using routine data to evaluate real-world public health interventions – assessing the reach, impact, and fidelity of The Daily Mile
Creators: name: Venkatraman, Tishya
Publisher: name: Imperial College London
Year: 2021

description: Background Public health interventions are often promoted without strong evidence of effectiveness in real-world settings. In England there is a vast amount of routine data available that can be used to evaluate these interventions. Less than 50% of children in England meet the government’s physical activity guidelines, which is a major public health concern. Simple, effective interventions for all are required to tackle shortfalls in children’s physical activity. The Daily Mile (TDM) is a school-based active mile intervention that has been widely adopted to address this shortfall. This thesis aims to use routine data to evaluate a real-world public health intervention by assessing the reach, impact, and fidelity of TDM. Methods This thesis comprises four cross-sectional studies linking various health, education, and census data. In the first study, I created a database of all state-funded primary schools in England and used multilevel models to determine the association between school and local authority characteristics, and registration to TDM. In the second study, I conducted a hierarchical cluster analysis to group local authorities by ‘need’ and estimated the association between ‘need’ and registration to TDM. In the third study, I used self-reported physical activity data to compare minutes of MVPA, and the variety of activities reported per week between children attending TDM-registered and non-TDM registered schools. Finally, I assessed fidelity to TDM’s core running criteria among children registered using descriptive statistics and multilevel models. Results TDM is a wide-reaching intervention with one in five primary schools in England registered. Schools in urban areas and schools with a higher proportion of disadvantaged pupils were more likely to register. TDM appears to be an equitable intervention reaching schools in areas of highest need; registration ranged from one in five schools in low-need areas to one in four in high-need areas. Children attending schools registered to TDM reported a marginally greater variety of activity and 10 additional minutes of MVPA/week during school hours and 26 additional minutes of MVPA/week outside school hours compared to children in non-TDM schools. Fidelity of implementation to TDM remained low, where 30% of those registered reported adhering to TDM’s core running criteria. Conclusion This thesis demonstrates that routine data can effectively be used to evaluate real-world public health interventions. TDM is a wide-reaching intervention and appears to be equitable. However, it does not seem to impact children’s physical activity substantially, and implementation remains low. TDM must be embedded within a broader suite of interventions to increase children’s physical activity.
sj-pdf-1-ajs-10.1177_03635465211003342 – Supplemental material for Inconsistencies in Reporting Risk Factors for Medial Patellofemoral Ligament Reconstruction Failure: A Systematic Review
Creators: name: Cregar, William M.
name: Huddleston, Hailey P.
name: Wong, Stephanie E.
name: Farr, Jack
name: Yanke, Adam B.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences
subject: 110323 Surgery

description: Supplemental material, sj-pdf-1-ajs-10.1177_03635465211003342 for Inconsistencies in Reporting Risk Factors for Medial Patellofemoral Ligament Reconstruction Failure: A Systematic Review by William M. Cregar, Hailey P. Huddleston, Stephanie E. Wong, Jack Farr and Adam B. Yanke in The American Journal of Sports Medicine
Clinically and biologically inspired strategies to alleviate skin fibrosis
Creators: name: Plotczyk, Magdalena
Publisher: name: Imperial College London
Year: 2021

description: Fibrotic diseases constitute a major health problem worldwide owing to the large number of affected individuals and a lack of effective disease-modifying therapeutic solutions. It is therefore clear that new biological insights and engineering strategies are needed to address this daunting unmet medical need. In this PhD study, I present two novel approaches to alleviate fibrosis, focusing on skin scarring as a model tissue. The first approach is inspired by the laxity paradox, a clinical observation made in patients undergoing hair transplantation. This phenomenon describes formation of wide stretched scars in patients with very loose scalp skin and low skin tension, an observation that is in contrary to the previously established and generally accepted link between an increased skin tension and extensive scarring. I have decided to explore the mechanism of the low-tension scarring and identified downregulation of the expression of thrombospondin 1 and 2 in dermal fibroblasts isolated from the scar as a possible contributing factor. The second approach was inspired by how healthy hair-bearing skin undergoes physiological remodelling during the regular hair follicle cycle. In a pilot clinical study in collaboration with a hair transplantation clinic, we tested if anagen hair follicles transplanted into human scars can actively remodel fibrotic tissue, similar to how they remodel the healthy skin. I tested the fibrotic tissue before and after hair transplantation and found a shift in the morphology and transcriptional profile towards the healthy phenotype. I expect the results of this thesis to inspire further research into both the role of thrombospondins in low-tension scarring and the observation of hair follicle-induced scar remodelling. Long term, increased understanding of the mechanisms behind scar formation and complex interactions between cells in the fibrotic environment could contribute to the design of novel therapeutic strategies to achieve the holy grail of scarless skin regeneration.
Investigation of the evolutionary link between the enteric neuronal system and immune system using the early vertebrate species Danio rerio
Creators: name: Wenz, Ralf
Publisher: name: Imperial College London
Year: 2021

description: Neuroimmunology in healthy homeostasis has recently attracted attention, especially in the brain. The intestine, in contrast, and its neuroimmunological interactions are much overlooked. While models regarding how neuroimmune similarities have been put forward, there is a gap as to why and when neuroimmune interactions in the intestine might have arisen. To fill this gap, I herein put forward a theoretical framework postulating that intestinal neuroimmune interactions have arisen in early vertebrates, thus allowing the sensing and expelling of pathogens from the intestine via peristalsis. Immune cells, I postulate, sense the pathogens and signal to neurons to increase intestinal peristalsis, expelling pathogens from the intestine; thus leading to higher survival rates. Using the early vertebrate species Danio rerio (zebrafish), I show that there is tantalising but tentative evidence that exposure to lysed Mycobacterium marinum increases peristalsis of the intestinal bulb, hinting at the possibility of the existence of a mechanism that expels pathogens from the intestine via peristalsis. Besides this main finding, I also established new and needed baseline readings of intestinal peristalsis. These new readings show the vital importance of accurately controlling for ambient temperature and anaesthetic concentration during measurements. Moreover, I demonstrate that macrophages are important for regular homeostatic peristalsis of the intestine in the early vertebrate Danio rerio, like the mammalian counterpart, the mouse. In order to achieve the above results, several new pieces of equipment and methods had to be developed. Firstly, I developed the Multiscope, a system of multiple microscopes combined that allow the imaging of many specimens simultaneously at controlled temperatures for long periods of time in an affordable manner. By building four Multiscopes from simple and cheap components I was able to acquire in one month the data that would have, using conventional equipment, required an entire year. Further, I established a fast, easy and early procedure to identify transparent mutant zebrafish, by which an estimated 60,000 animals could be saved worldwide every year (Wenz et al., 2020).
Additional file 2 of Interaction models matter: an efficient, flexible computational framework for model-specific investigation of epistasis
Creators: name: Batista, Sandra
name: Madar, Vered Senderovich
name: Freda, Philip J.
name: Bhandary, Priyanka
name: Ghosh, Attri
name: Matsumoto, Nicholas
name: Chitre, Apurva S.
name: Palmer, Abraham A.
name: Moore, Jason H.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Additional file 2. S2 File. Penetrance Functions and Additional Experiments. This file contains examples of theoretical penetrance functions and the sample penetrance functions from loci in the mouse and rat data sets. In addition, this file contains results from correlation tests in rats between GWAS summary statistics and detected epistatic events in rats and GO-term enrichment dotplots for GWAS QTLs in rats and mice.
Exploring the effects of diet-induced obesity on the invasiveness of Drosophila tumours
Creators: name: Cabrera Diaz, Cecilia
Publisher: name: Imperial College London
Year: 2021

description: Epidemiological studies have shown that obesity promotes cancer development, but whether obesity affects cancer invasion is relatively not well understood. In addition, while cancer is a genetically heterogeneous disease, little is known about whether tumours of different genetic profiles respond differently to obesity. By leveraging the model organism Drosophila melanogaster, this thesis explores (i) whether obesity affects the invasiveness of tumours, and (ii) whether and how different tumours exhibit different invasiveness in response to obesity. By combining a series of Drosophila models of colorectal cancers with a Drosophila model of diet-induced obesity, I demonstrate that obesity modulates the invasiveness of different tumours to different degrees. Furthermore, I demonstrate that tumours of different genetic profiles respond to obesity with a different directionality depending on the tumour’s pten status; while obesity increased the invasiveness of pten-intact tumours, obesity did not promote the invasiveness of pten-deficient tumours. Surprisingly, obesity suppressed the invasiveness of rasG12V ptenRNAi tumours. In non-obese animals, rasG12V ptenRNAi tumours exhibited the strongest invasive phenotype; cellular and molecular characterisation revealed that rasG12V ptenRNAi tumours displayed multiple features of epithelial-mesenchymal transition and invaded a specific location in the colorectum. However, obesity reverted these phenotypes, suggesting that obesity significantly and specifically suppresses the invasive properties of rasG12V ptenRNAi tumours. RNA-Sequencing analysis of rasG12V ptenRNAi tumours revealed increased Reactive Oxygen Species (ROS) as a mediator of obesity-mediated suppression of invasion. I present functional data showing dietary and genetic manipulation to elevate systemic or tumour-specific ROS levels is sufficient to suppress the invasiveness of rasG12V ptenRNAi tumour cells. These results demonstrate an inhibitory role of ROS in the invasiveness of rasG12V ptenRNAi tumours in response to obesity. Overall, the work presented in this thesis highlights Drosophila as a model system to study the interactions between diet, obesity, and tumour heterogeneity in a whole-animal setting.