cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Evaluation of agonist and antagonist radioligands for somatostatin receptor imaging of breast cancer using positron emission tomography
Creators: name: Dude, Iulia
name: Zhang, Zhengxing
name: Rousseau, Julie
name: Hundal-Jabal, Navjit
name: Colpo, Nadine
name: Merkens, Helen
name: Lin, Kuo-Shyan
name: Bénard, François
Publisher: name: Springer International Publishing
Year: 2018

description: Background: The somatostatin receptor subtype 2 (sstr2) is expressed on a majority of luminal breast cancers, however SPECT and scintigraphy imaging with agonistic sstr2 probes has been sub-optimal. High affinity antagonists can access more binding sites on the cell surface, resulting in higher tumor uptake and improved sensitivity. We compared the tumor uptake and biodistribution of the antagonist 68Ga-NODAGA-JR11 with two agonists 68Ga-DOTA-Tyr3-octreotide (68Ga-DOTATOC) and 68Ga-DOTA-Tyr3-octreotate (68Ga-DOTATATE), in the human, sstr2-positive, luminal breast cancer model: ZR-75-1. Results: Peptides were assayed for binding affinity using a filtration-based competitive assay to sstr2. natGa-DOTATOC and natGa-DOTATATE had excellent affinity (inhibition constant Ki: 0.9 ± 0.1 nM and 1.4 ± 0.3 nM respectively) compared to natGa-NODAGA-JR11 (25.9 ± 0.2 nM). The number of binding sites on ZR-75-1 cells was determined in vitro by saturation assays. Agonist 67/natGa-DOTATOC bound to 6.64 ± 0.39 × 104 sites/cells, which was 1.5-fold higher than 67/natGa-NODAGA-JR11 and 2.3-fold higher than 67/natGa-DOTATATE. All three 68Ga-labeled peptides were obtained in good decay-corrected radiochemical yield (61-68%) and were purified by high performance liquid chromatography to ensure high specific activity (137 – 281 MBq/nmol at the end of synthesis). NOD scid gamma mice bearing ZR-75-1 tumors were injected intravenously with the labeled peptides and used for PET/CT imaging and biodistribution at 1 h post-injection. We found that 68Ga-DOTATOC had the highest tumor uptake (18.4 ± 2.9%ID/g), followed by 68Ga-DOTATATE (15.2 ± 2.2%ID/g) and 68Ga-NODAGA-JR11 (12.2 ± 0.8%ID/g). Tumor-to-blood and tumor-to-muscle ratios were also higher for the agonists (>40 and >150 respectively), compared to the antagonist (15.6 ± 2.2 and 45.2 ± 11.6 respectively). Conclusions: The antagonist 68Ga-NODAGA-JR11 had the lowest tumor uptake and contrast compared to agonists 68Ga-DOTATOC and 68Ga-DOTATATE in ZR-75-1 xenografts. The main contributing factor to this result could be the use of an endogenously expressing cell line, which may differ from previously published transfected models in the number of low-affinity, antagonist-specific binding sites. The relative merit of agonists versus antagonists for sstr2 breast cancer imaging warrants further investigation, first in preclinical models with other sstr2-positive breast cancer xenografts, and ultimately in luminal breast cancer patients.
Buchbesprechung: Rüdiger Machetzki, Die ASEAN-Länder. Leistungsprofile, Märkte, Kooperationsaussichten
Creators: name: Schmidt, Frithjof
Publisher: name: südostasien informationen
Year: 2018

description: südostasien informationen, Bd. 3 Nr. 3 (1987): südostasien informationen
The Universe, the Light, the Earth, the Life: the Reality is Greater than We Are
Creators: name: Balzani, Vincenzo
Publisher: name: Substantia
Year: 2020

description: The pandemic caused by Covid-19 locked us at home for several weeks. Some clever town councillors took this opportunity to offer their citizens cultural pills. In my little town I was asked to present a few short lectures on general scientific concepts. I tried to link together four entities of reality (Universe, Light, Earth and Life) showing that reality is much more complex than we think and much greater than us. E.g.: age of the Universe vs age of human civilization (~1.3x1010 vs ~ 1x104 years), size of universe vs human size (~1x1025 m vs ~1 m), velocity of light vs velocity of sound (3x108 vs 3.5x102 m/s), number of stars in the sky (~ 1x1023), number of molecule in a drop of water (~ 3x1021), number of atoms in a human body (~ 1x1027). Although we know reasonably well how Universe, Light, Earth and Life “work”, we are still surrounded by profound mysteries related to the why questions, i.e., the “questions of meaning”, that science cannot answer. Such questions, e.g., why is there the Universe? Why is there Life in this insignificant fragment of the Universe called Earth? Why did the evolution of Life lead to human? What's the meaning of my life? What is the meaning of the Covid-19 pandemic? The answers to the these “questions of meaning”, that cannot be given by science, are discussed in the enciclic Laudato si’ of pope Francis in relation to the ecological and social crisis we are going through.
description: Substantia, Vol 4 No 1 Suppl. 1 (2020) - Open Stream on Covid-19 Emergency
Additional file 16 of The Tug1 lncRNA locus is essential for male fertility
Creators: name: Lewandowski, Jordan P.
name: Dumbović, Gabrijela
name: Watson, Audrey R.
name: Taeyoung Hwang
name: Jacobs-Palmer, Emily
name: Chang, Nydia
name: Much, Christian
name: Turner, Kyle M.
name: Kirby, Christopher
name: Rubinstein, Nimrod D.
name: Groff, Abigail F.
name: Liapis, Steve C.
name: Gerhardinger, Chiara
name: Bester, Assaf
name: Pandolfi, Pier Paolo
name: Clohessy, John G.
name: Hopi E. Hoekstra
name: Sauvageau, Martin
name: Rinn, John L.
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 16: Fig. S11. Uncropped western blot images from Figure 5e. Original, uncropped images of western blots shown in Figure 5e. (A) Western blot of constructs overexpressed in 3T3 cells targeting the 3xFLAG tag (top). GAPDH is used as a loading control (bottom). (B) Western blot of constructs overexpressed in HeLa cells targeting the 3xFLAG tag (top). GAPDH is used as a loading control (bottom).
Additional file 4 of The Tug1 lncRNA locus is essential for male fertility
Creators: name: Lewandowski, Jordan P.
name: Dumbović, Gabrijela
name: Watson, Audrey R.
name: Taeyoung Hwang
name: Jacobs-Palmer, Emily
name: Chang, Nydia
name: Much, Christian
name: Turner, Kyle M.
name: Kirby, Christopher
name: Rubinstein, Nimrod D.
name: Groff, Abigail F.
name: Liapis, Steve C.
name: Gerhardinger, Chiara
name: Bester, Assaf
name: Pandolfi, Pier Paolo
name: Clohessy, John G.
name: Hopi E. Hoekstra
name: Sauvageau, Martin
name: Rinn, John L.
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 4: Fig. S4. Morphology analysis of Tug1-/- mice and sperm (A) Body mass (g) measurements over 11 weeks of male and female Tug1-/- mice compared to wild type littermates. Males: Tug1-/- (n = 7); WT (n = 8). Females: Tug1-/- (n = 3), WT (n = 7). Significant p values at specific time points are indicated (*). (B) Representative images from adult male mice (12 weeks old) show normal physiological appearance of external genitalia and reproductive tracks in Tug1-/- compared to WT. Seminal vesicles (SV), vas deferens (VD), bladder (B), testicle (T), epididymis (E), anterior prostate (AP). (C) Box plots of body mass (g) (left panel), relative testis mass (testis mass / body mass; middle panel) and total sperm count for wild type (n = 9) and Tug1-/- males. (D) Box plots of the percentage of different sperm morphological abnormalities for wild type (n = 9) and Tug1-/- (n = 8) males. Significant (*) p value (Wilcoxon rank sum test) is indicated.
Quantum Wave Function Collapse for Procedural Content Generation
Creators: name: Heese, Raoul
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: Graphics (cs.GR)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Quantum computers exhibit an inherent randomness, so it seems natural to consider them for procedural content generation. In this work, a quantum version of the famous (classical) wave function collapse algorithm is proposed. This quantum wave function collapse algorithm is based on the idea that a quantum circuit can be prepared in such a way that it acts as a special-purpose random generator for content of a desired form. The proposed method is presented theoretically and investigated experimentally on simulators and IBM Quantum devices.
description: 13 pages, 11 figures
Pramoedya Ananta Toer "Meine Schriften sind identisch mit mir selbst"
Creators: name: Hoff, Walter
Publisher: name: südostasien informationen
Year: 2018

description: Ein mittlerweile 60jähriger Mann - er sieht vital aus und ist doch gekennzeichnet von seiner jahrelangen Haftzeit, von seinem Veröffentlichungs- und Auftrittsverbot. Pram, wie er genannt wird, lebt zurückgezogen in Jakarta, der indonesischen Hauptstadt. Er hat sich ein tägliches Arbeitspensum auferlegt, schreibt an einem sozialgeografischen Handbuch; er hält seine Erinnerungen fest und arbeitet viele der Themen auf, die ihn jahrelang beschäftigt haben. Gegenwärtig lebt er de facto unter Stadtarrest. Pram ist der bekannteste indonesische Romancier und Erzähler ... doch das herrschende Regime untersagt ihm, seine Werke zu veröffentlichen. Nachdem er in der Folge des Staatsstreiches 1965 in Haft kam - und erst 1979 freigelassen wurde - ist ihm zwar das Schreiben nicht verboten worden, jedoch das Publizieren. In den letzten Monaten äußerte Pram sich in mehreren Gesprächen zu seinen Büchern, zum Veröffentlichungsverbot und zu seinen Lebensbedingungen.
description: südostasien informationen, Bd. 2 Nr. 4 (1986): südostasien informationen
Uncertainty-biased molecular dynamics for learning uniformly accurate interatomic potentials
Creators: name: Zaverkin, Viktor
name: Holzmüller, David
name: Christiansen, Henrik
name: Errica, Federico
name: Alesiani, Francesco
name: Takamoto, Makoto
name: Niepert, Mathias
name: Kästner, Johannes
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computational Physics (physics.comp-ph)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Machine Learning (stat.ML)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Efficiently creating a concise but comprehensive data set for training machine-learned interatomic potentials (MLIPs) is an under-explored problem. Active learning, which uses biased or unbiased molecular dynamics (MD) to generate candidate pools, aims to address this objective. Existing biased and unbiased MD-simulation methods, however, are prone to miss either rare events or extrapolative regions -- areas of the configurational space where unreliable predictions are made. This work demonstrates that MD, when biased by the MLIP's energy uncertainty, simultaneously captures extrapolative regions and rare events, which is crucial for developing uniformly accurate MLIPs. Furthermore, exploiting automatic differentiation, we enhance bias-forces-driven MD with the concept of bias stress. We employ calibrated gradient-based uncertainties to yield MLIPs with similar or, sometimes, better accuracy than ensemble-based methods at a lower computational cost. Finally, we apply uncertainty-biased MD to alanine dipeptide and MIL-53(Al), generating MLIPs that represent both configurational spaces more accurately than models trained with conventional MD.
Additional file 17 of The Tug1 lncRNA locus is essential for male fertility
Creators: name: Lewandowski, Jordan P.
name: Dumbović, Gabrijela
name: Watson, Audrey R.
name: Taeyoung Hwang
name: Jacobs-Palmer, Emily
name: Chang, Nydia
name: Much, Christian
name: Turner, Kyle M.
name: Kirby, Christopher
name: Rubinstein, Nimrod D.
name: Groff, Abigail F.
name: Liapis, Steve C.
name: Gerhardinger, Chiara
name: Bester, Assaf
name: Pandolfi, Pier Paolo
name: Clohessy, John G.
name: Hopi E. Hoekstra
name: Sauvageau, Martin
name: Rinn, John L.
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 17. Review history.
Indonesien: Islam, Krise und kulturelle Identität
Creators: name: Knoke, Dieter
name: Öttinger, Gernot
Publisher: name: südostasien informationen
Year: 2018

description: In den letzten Jahren kam es sowohl in Indonesien als auch in anderen Ländern zu einer verstärkten Revitalisierung der Islamischen Bewegung. Ein Indiz hierfür ist der Zwischenfall von Tanjung Priok 1984, bei dem es anläßlich einer Demonstration islamischer Aktivisten, die brutal zerschlagen wurde, zu einem Massaker kam. Seitens islamischer Aktivisten wurden auch mehrere Bombenanschläge auf Banken und andere Institutionen, die den Staat repräsentieren, verübt. (...)
description: südostasien informationen, Bd. 2 Nr. 4 (1986): südostasien informationen
A password you can swallow? Don't hold your breath
Creators: name: Hamlyn-Harris, James
Publisher: name: Swinburne
Year: 2024

description: Do you have trouble remembering all your passwords, PINs and identification codes? If you believe the hype, you could soon be swallowing away all your problems with a “password pill”. But don’t hold your breath for this technology – better alternatives are already available. News reports have suggested a swallowable device can beam user IDs and passwords to a smartphone or tablet. What they’re talking about is a component of Proteus Digital Health Feedback System, developed by Motorola.
Emergent half-metal with mixed structural order in (111)-oriented (LaMnO$_3$)$_{2n}$|(SrMnO$_3$)$_n$ superlattices
Creators: name: Cossu, Fabrizio
name: Nascimento, Jùlio Alves Do
name: Cavill, Stuart A.
name: Di Marco, Igor
name: Lazarov, Vlado K.
name: Kim, Heung-Sik
Publisher: name: arXiv
Year: 2023
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Using first-principles techniques, we study the structural, magnetic and electronic properties of (111)-oriented (LaMnO$_3$)$_{2n}$$\vert$(SrMnO$_3$)$_{n}$ superlattices of varying thickness ($n=2,4,6$). We find that the properties of the thinnest superlattice ($n=2$) are similar to the celebrated half-metallic ferromagnetic alloy La$_{2/3}$Sr$_{1/3}$MnO$_3$, with quenched Jahn-Teller distortions. At intermediate thickness ($n=4$), the $a^{-}a^{-}a^{-}$ tilting pattern transitions to the $a^{-}a^{-}c^{+}$ tilting pattern, driven by the lattice degrees of freedom in the LaMnO$_3$ region. The emergence of the Jahn-Teller modes and the spatial extent needed for their development play a key role in this structural transition. For the largest thickness considered ($n=6$), we unveil an emergent separation of Jahn-Teller and volume-breathing orders in the ground-state structure with the $a^{-}a^{-}c^{+}$ tilting pattern, whereas it vanishes in the antiferromagnetic configurations. The ground state of all superlattices is half-metallic ferromagnetic, not affected by the underlying series of structural transitions. Overall, these results outline a thickness-induced crossover between the physical properties of bulk La$_{2/3}$Sr$_{1/3}$MnO$_3$ and bulk LaMnO$_3$.
description: 7 pages excluding references, 8 figures
Additional file 2 of The Tug1 lncRNA locus is essential for male fertility
Creators: name: Lewandowski, Jordan P.
name: Dumbović, Gabrijela
name: Watson, Audrey R.
name: Taeyoung Hwang
name: Jacobs-Palmer, Emily
name: Chang, Nydia
name: Much, Christian
name: Turner, Kyle M.
name: Kirby, Christopher
name: Rubinstein, Nimrod D.
name: Groff, Abigail F.
name: Liapis, Steve C.
name: Gerhardinger, Chiara
name: Bester, Assaf
name: Pandolfi, Pier Paolo
name: Clohessy, John G.
name: Hopi E. Hoekstra
name: Sauvageau, Martin
name: Rinn, John L.
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Fig. S2. In vivo expression pattern of Tug1 during murine embryogenesis. RNA in situ hybridization of Tug1 RNA using a digoxigenin-labeled antisense RNA probe in mouse embryos at different developmental stages. Embryonic day (E)8.5, E9.5, E10.5, E11.5, and E12.5 are shown.
Singapur. Der Niedergang J. B. Jeyaretnams
Creators: name: Schneider, Larry
Publisher: name: südostasien informationen
Year: 2018

description: Am 10. Oktober verurteilte das Oberste Gericht Singapurs M.B. Jeyaretnam, Generalsekretär der Workers' Party und Parlamentsabgeordneter für den Wahlkreis Anson, zu einem Monat Gefängnis und $ 5000 Geldstrafe und änderte damit ein vorangegangenes Urteil von drei Monaten Gefängnis ohne Geldstrafe. Praktisch bedeutet dieses Urteil den Verlust seines Parlamentsmandates, denn nach § 45 der Verfassung von Singapur verliert ein Parlamentsmitglied sein Mandat, wenn es vom Gericht zu einer Geldstrafe von mindestens $ 2000 oder zu einer Gefängnisstrafe von nicht weniger als einem Jahr verurteilt wurde. (...)
description: südostasien informationen, Bd. 2 Nr. 4 (1986): südostasien informationen
Generating synthetic star catalogs from simulated data for next-gen observatories with py-ananke
Creators: name: Thob, Adrien C. R.
name: Sanderson, Robyn E.
name: Eden, Andrew P.
name: Nikakhtar, Farnik
name: Panithanpaisal, Nondh
name: Garavito-Camargo, Nicolás
name: Sharma, Sanjib
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: We find ourselves on the brink of an exciting era in observational astrophysics, driven by groundbreaking facilities like JWST, Euclid, Rubin, Roman, SKA, or ELT. Simultaneously, computational astrophysics has shown significant strides, yielding highly realistic galaxy formation simulations, thanks to both hardware and software enhancements. Bridging the gap between simulations and observations has become paramount for meaningful comparisons. We introduce py-ananke, a Python pipeline designed to generate synthetic resolved stellar surveys from cosmological simulations, adaptable to various instruments. Building upon its predecessor, ananke by Sanderson et al. 2020 (arXiv:1806.10564), which produced Gaia DR2 mock star surveys, the py-ananke package offers a user-friendly "plug & play" experience. The pipeline employs cutting-edge phase-space density estimation and initial mass function sampling to convert particle data into synthetic stars, while interpolating pre-computed stellar isochrone tracks for photometry. Additionally, it includes modules for estimating interstellar reddening, dust-induced extinctions, and for quantifying errors through dedicated modeling approaches. py-ananke promises to serve as a vital bridge between computational astrophysics and observational astronomy, facilitating preparations and making scientific predictions for the next generation of telescopes.
description: 12 pages (6 pages of bibliography) and 1 figure. Software repository at https://github.com/athob/py-ananke
Additional file 3 of The Tug1 lncRNA locus is essential for male fertility
Creators: name: Lewandowski, Jordan P.
name: Dumbović, Gabrijela
name: Watson, Audrey R.
name: Taeyoung Hwang
name: Jacobs-Palmer, Emily
name: Chang, Nydia
name: Much, Christian
name: Turner, Kyle M.
name: Kirby, Christopher
name: Rubinstein, Nimrod D.
name: Groff, Abigail F.
name: Liapis, Steve C.
name: Gerhardinger, Chiara
name: Bester, Assaf
name: Pandolfi, Pier Paolo
name: Clohessy, John G.
name: Hopi E. Hoekstra
name: Sauvageau, Martin
name: Rinn, John L.
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3: Fig. S3. Overview of the Tug1 locus in mouse. UCSC genome browser showing the murineTug1 locus. The three predominate Tug1 isoforms are depicted (black) and the Tug1 transgene (tg(Tug1)) is shown (blue). For Tug1 knockout, the longest annotated Tug1 isoform was replaced by a lacZ reporter cassette, leaving the promotor and first exon intact. The deleted region is indicated by red dashed lines. The open reading frame (ORF) encoding the TUG1-BOAT protein and PhyloCSF scores for the (-2) frame across the locus are depicted (grey). Chromosomal coordinates (mm10) are shown.
Plücker Coordinates and the Rosenfeld Planes
Creators: name: Qiu, Jian
Publisher: name: arXiv
Year: 2024
Subjects: subject: Algebraic Geometry (math.AG)
subject: High Energy Physics - Theory (hep-th)
subject: Differential Geometry (math.DG)
subject: Symplectic Geometry (math.SG)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 53A20, 17C40

description: The exceptional compact hermitian symmetric space EIII is the quotient $E_6/Spin(10)\times_{\mathbb{Z}_4}U(1)$. We introduce the Plücker coordinates which give an embedding of EIII into $\mathbb{C}P^{26}$ as a projective subvariety. The subvariety is cut out by 27 Plücker relations. We show that, using Clifford algebra, one can solve this over-determined system of relations, giving local coordinate charts to the space.
 Our motivation is to understand EIII as the complex projective octonion plane $(\mathbb{C}\otimes\mathbb{O})P^2$, whose construction is somewhat scattered across the literature. We will see that the EIII has an atlas whose transition functions have clear octonion interpretations, apart from those covering a sub-variety $X_{\infty}$ of dimension 10. This subvariety is itself a hermitian symmetric space known as DIII, with no apparent octonion interpretation. We give detailed analysis of the geometry in the neighbourhood of $X_{\infty}$.
 We further decompose $X={\rm EIII}$ into $F_4$-orbits: $X=Y_0\cup Y_{\infty}$, where $Y_0\sim(\mathbb{O}P^2)_{\mathbb{C}}$ is an open $F_4$-orbit and is the complexification of $\mathbb{O}P^2$, whereas $Y_{\infty}$ has co-dimension 1, thus EIII could be more appropriately denoted as $\overline{(\mathbb{O}P^2)_{\mathbb{C}}}$. This decomposition appears in the classification of equivariant completion of homogeneous algebraic varieties by Ahiezer \cite{Ahiezer}.
description: 44 pages, final version published in J.Geom.Phys
SimBoost: a read-across approach for predicting drug–target binding affinities using gradient boosting machines
Creators: name: He, Tong
name: Heidemeyer, Marten
name: Ban, Fuqiang
name: Cherkasov, Artem
name: Ester, Martin
Publisher: name: Springer International Publishing
Year: 2018

description: Computational prediction of the interaction between drugs and targets is a standing challenge in the field of drug discovery. A number of rather accurate predictions were reported for various binary drug–target benchmark datasets. However, a notable drawback of a binary representation of interaction data is that missing endpoints for non-interacting drug–target pairs are not differentiated from inactive cases, and that predicted levels of activity depend on pre-defined binarization thresholds. In this paper, we present a method called SimBoost that predicts continuous (non-binary) values of binding affinities of compounds and proteins and thus incorporates the whole interaction spectrum from true negative to true positive interactions. Additionally, we propose a version of the method called SimBoostQuant which computes a prediction interval in order to assess the confidence of the predicted affinity, thus defining the Applicability Domain metrics explicitly. We evaluate SimBoost and SimBoostQuant on two established drug–target interaction benchmark datasets and one new dataset that we propose to use as a benchmark for read-across cheminformatics applications. We demonstrate that our methods outperform the previously reported models across the studied datasets.
IntraSeismic: a coordinate-based learning approach to seismic inversion
Creators: name: Romero, Juan
name: Heidrich, Wolfgang
name: Luiken, Nick
name: Ravasi, Matteo
Publisher: name: arXiv
Year: 2023
Subjects: subject: Geophysics (physics.geo-ph)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Machine Learning (cs.LG)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Seismic imaging is the numerical process of creating a volumetric representation of the subsurface geological structures from elastic waves recorded at the surface of the Earth. As such, it is widely utilized in the energy and construction sectors for applications ranging from oil and gas prospection, to geothermal production and carbon capture and storage monitoring, to geotechnical assessment of infrastructures. Extracting quantitative information from seismic recordings, such as an acoustic impedance model, is however a highly ill-posed inverse problem, due to the band-limited and noisy nature of the data. This paper introduces IntraSeismic, a novel hybrid seismic inversion method that seamlessly combines coordinate-based learning with the physics of the post-stack modeling operator. Key features of IntraSeismic are i) unparalleled performance in 2D and 3D post-stack seismic inversion, ii) rapid convergence rates, iii) ability to seamlessly include hard constraints (i.e., well data) and perform uncertainty quantification, and iv) potential data compression and fast randomized access to portions of the inverted model. Synthetic and field data applications of IntraSeismic are presented to validate the effectiveness of the proposed method.
description: -
Outcomes following percutaneous coronary revascularization among South Asian and Chinese Canadians
Creators: name: Mackay, Martha
name: Singh, Robinder
name: Boone, Robert H.
name: Park, Julie E.
name: Humphries, Karin H.
Publisher: name: BioMed Central
Year: 2017

description: Background: Previous data suggest significant ethnic differences in outcomes following percutaneous coronary revascularization (PCI), though previous studies have focused on subgroups of PCI patients or used administrative data only. We sought to compare outcomes in a population-based cohort of men and women of South Asian (SA), Chinese and “Other” ethnicity. Methods: Using a population-based registry, we identified 41,792 patients who underwent first revascularization via PCI in British Columbia, Canada, between 2001 and 2010. We defined three ethnic groups (SA, 3904 [9.3%]; Chinese, 1345 [3.2%]; and all “Others” 36,543 [87.4%]). Differences in mortality, repeat revascularization (RRV) and target vessel revascularization (TVR), at 30 days and from 31 days to 2 years were examined. Results: Adjusted mortality from 31 days to 2 years was lower in Chinese patients than in “Others” (hazard ratio [HR] 0.72; 95% confidence interval [CI] 0.53-0.97), but not different between SAs and “Others”. SA patients had higher RRV at 30 days (adjusted odds ratio [OR] 1.30; 95% CI: 1.12-1.51) and from 31 days to 2 years (adjusted hazard ratio [HR] 1.17; 95% CI: 1.06-1.30) compared to “Others”. In contrast, Chinese patients had a lower rate of RRV from 31 days to 2 years (adjusted HR 0.79; 95% CI: 0.64-0.96) versus “Others”. SA patients also had higher rates of TVR at 30 days (adjusted OR 1.35; 95% CI: 1.10-1.66) and from 31 days to 2 years (adjusted HR 1.19; 95% CI: 1.06-1.34) compared to “Others”. Chinese patients had a lower rate of TVR from 31 days to 2 years (adjusted HR 0.76; 95% CI: 0.60-0.96). Conclusions: SA had higher RRV and TVR rates while Chinese Canadians had lower rates of long-term RRV, compared to those of “Other” ethnicity. Further research to elucidate the reasons for these differences could inform targeted strategies to improve outcomes.
Malaysias "nationale Kultur"
Creators: name: Prajs-Tio, M.
Publisher: name: südostasien informationen
Year: 2018

description: In kaum einem anderen Land ist das kulturelle und religiöse Leben von einer so großen Vielfalt geprägt wie in Malaysia. Islamische Malayen auf der malaiischen Halbinsel und die Ureinwohner Sarawaks und Sabahs erlebten während der britischen Kolonialherrschaft einen gewaltigen Zustrom von chinesischen und indischen Zuwanderern, so daß heute die 16 Millionen Bevölkerung zu 36% chinesischer und 10% indischer Abstammung sind. Die Briten hatten ihnen klare ökonomische Rollen in der Kolonialwirtschaft zugewiesen - Chinesen als Arbeiter in den Zinnminen und den Hafenstädten, Inder als Arbeiter/innen auf den großen Kautschukplantagen - um den Status der kleinbäuerlichen Malayen nicht zu verändern. (...)
description: südostasien informationen, Bd. 2 Nr. 4 (1986): südostasien informationen
AN EXAMINING CLUSTER BEHAVIOUR ANALYTICALLY USING K- MEANS, EM, AND K* MEANS ALGORITHM
Creators: name: Dr. MARRIAPPAN E
name: Dr. ANNA LAKSHMI A
name: AMALA PRINCETON X
name: VETRIVEL P
name: Dr. RAMASAMY S
name: ANGEL HEPHZIBAH R
name: Dr. KALIAPPAN M
name: RAMNATH M
Publisher: name: Zenodo
Year: 2024
Subjects: Cluster Analysis, Mean Value Analysis, EM, K- means, K*means, Purity, Entropy, Purity and Entropy.

description: Abstract

An essential component of an intelligent data analysis process is clustering, an unsupervised learning technique. By grouping the patterns into homogeneous clusters, it facilitates the investigation of the links between the patterns. In the realm of information retrieval(IR), clustering has been dynamically applied to arrange of applications. One of the most active areas of study and development nowadays is clustering. By using clustering, one can find the set of significant groups in which members are more linked to each other than to members of other groups. There salting groupings can offer a framework for arranging length by text sections to make browsing and searching easier. Numerous clustering techniques have been thoroughly examined in relation to the clustering problem. Expectation Maximization(EM) and its variations, as well as the well-known link-means algorithm, are examples of iterative optimization clustering algorithms that have been shown to perform rather well for clustering. These algorithms are still among the most popular and effective. In the heart spect dataset, which has the following features: purity, entropy, CPU time, cluster-wise analysis, mean value analysis, and inter-cluster distance, this study examines the partition method clustering approaches, EM, Kmeans and K*Means algorithm. In order to support the conclusion that the behaviour in clusters produced by the EM algorithm is of a higher calibre than that of the k-means and k*means algorithms, the research finally presents the experimental results from datasets for five clusters.
How will your energy get greener? Depends where you live
Creators: name: Newton, Peter
name: Newman, Peter
Publisher: name: Swinburne
Year: 2024

description: In Australia’s middle and outer suburbs, rooftop solar technology provides a clear way to reduce the emissions from the energy our houses use. But higher density housing types (apartments and medium density housing) do not lend themselves to rooftop solar at the scale needed to make a difference to household energy and carbon budgets. So how will those people living in inner suburbs make the change to lower-carbon energy?
Environment-stored memory in active nematics and extra-cellular matrix remodeling
Creators: name: Adar, Ram M.
name: Joanny, Jean-François
Publisher: name: arXiv
Year: 2024
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Many active systems display nematic order, while interacting with their environment. In this work, we show theoretically how environment-stored memory acts an effective external field that aligns active nematics. The coupling to the environment leads to substantial modifications of the known phase diagram and dynamics of active nematics, including nematic order at arbitrarily low densities and arrested domain coarsening. We are motivated mainly by cells that remodel fibers in their extra-cellular matrix (ECM), while being directed by the fibers during migration. Our predictions indicate that remodeling promotes cellular and ECM alignment, and possibly limits the range of ordered ECM domains, in accordance with recent experiments.
description: 5 pages main text + 9 pages supplemental material, 3 figures
Un-doing cycles of vengeance: Nelson Mandela, truth and reconciliation, and the design of social justice
Creators: name: Tunstall, Elizabeth Dori
Publisher: name: Swinburne
Year: 2024

description: In tribute to former South African President Nelson Mandela’s legacy, I devote this week’s column to understanding the values, design, and experiences of truth and reconciliation commissions and what it means to design processes for social justice.
Buchbesprechung: V. Zühlsdorf (Hrsg.): Wenn vom Tau der Reis erwacht. Eine Auswahl thailändischer Lyrik von früher Zeit bis heute
Creators: name: Schmidt, Einhard
Publisher: name: südostasien informationen
Year: 2018

description: südostasien informationen, Bd. 2 Nr. 4 (1986): südostasien informationen
Deep Learning model predicts the c-Kit-11 mutational status of canine cutaneous mast cell tumors by HE stained histological slides
Creators: name: Puget, Chloé
name: Ganz, Jonathan
name: Ostermaier, Julian
name: Konrad, Thomas
name: Parlak, Eda
name: Bertram, Christof Albert
name: Kiupel, Matti
name: Breininger, Katharina
name: Aubreville, Marc
name: Klopfleisch, Robert
Publisher: name: arXiv
Year: 2024
Subjects: subject: Biomolecules (q-bio.BM)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Machine Learning (cs.LG)
subject: FOS: Biological sciences
subject: FOS: Computer and information sciences
subject: J.3

description: Numerous prognostic factors are currently assessed histopathologically in biopsies of canine mast cell tumors to evaluate clinical behavior. In addition, PCR analysis of the c-Kit exon 11 mutational status is often performed to evaluate the potential success of a tyrosine kinase inhibitor therapy. This project aimed at training deep learning models (DLMs) to identify the c-Kit-11 mutational status of MCTs solely based on morphology without additional molecular analysis. HE slides of 195 mutated and 173 non-mutated tumors were stained consecutively in two different laboratories and scanned with three different slide scanners. This resulted in six different datasets (stain-scanner variations) of whole slide images. DLMs were trained with single and mixed datasets and their performances was assessed under scanner and staining domain shifts. The DLMs correctly classified HE slides according to their c-Kit 11 mutation status in, on average, 87% of cases for the best-suited stain-scanner variant. A relevant performance drop could be observed when the stain-scanner combination of the training and test dataset differed. Multi-variant datasets improved the average accuracy but did not reach the maximum accuracy of algorithms trained and tested on the same stain-scanner variant. In summary, DLM-assisted morphological examination of MCTs can predict c-Kit-exon 11 mutational status of MCTs with high accuracy. However, the recognition performance is impeded by a change of scanner or staining protocol. Larger data sets with higher numbers of scans originating from different laboratories and scanners may lead to more robust DLMs to identify c-Kit mutations in HE slides.
description: 17 pages, 3 figures, 4 tables
Additional file 1 of The Tug1 lncRNA locus is essential for male fertility
Creators: name: Lewandowski, Jordan P.
name: Dumbović, Gabrijela
name: Watson, Audrey R.
name: Taeyoung Hwang
name: Jacobs-Palmer, Emily
name: Chang, Nydia
name: Much, Christian
name: Turner, Kyle M.
name: Kirby, Christopher
name: Rubinstein, Nimrod D.
name: Groff, Abigail F.
name: Liapis, Steve C.
name: Gerhardinger, Chiara
name: Bester, Assaf
name: Pandolfi, Pier Paolo
name: Clohessy, John G.
name: Hopi E. Hoekstra
name: Sauvageau, Martin
name: Rinn, John L.
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Fig. S1. Mouse and human Tug1 locus and chromatin context in different cell types. (A) Tug1 mouse and (B) human genomic loci. Evolutionary nucleotide conservation (PhyloP) of the locus are presented along with the chromatin context (DNase I hypersensitive regions, histone modifications) and protein binding ChIP-seq peaks (Pol2, CTCF, SIN3A, COREST, SETDB1, HDAC2) from ENCODE (UCSC Genome Browser, mm9) datasets in the indicated cell types.
Heranführen an die Kultur Thailands
Creators: name: Nagavajara, Chetana
Publisher: name: südostasien informationen
Year: 2018

description: Im folgenden Artikel handelt es sich um eine Rede, die Chetana Nagavajara, Professor für Germanistik an der Universität Silpakorn in Nakorn Pathom, am 6. Dezember 1984 vor deutschen Besuchern im Rahmen des Thai-Deutschen Dialoges in Bangkok gehalten hat. Er begann mit einer Erklärung über Semiotik, der Lehre von den Zeichen, und Hermeneutik, der Kunst der Auslegung. In Thailand müsse man, wolle man kommunizieren und etwas verstehen, Zeichen setzen und auf Zeichen achten. (...)
description: südostasien informationen, Bd. 2 Nr. 4 (1986): südostasien informationen
Conductivity scaling and absence of localization in disordered nodal line semimetals
Creators: name: Paiva, Carolina
name: Behrends, Jan
Publisher: name: arXiv
Year: 2024
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Transport plays a key role in characterizing topological insulators and semimetals. Understanding the effect of disorder is crucial to assess the robustness of experimental signatures for topology. In this work, we find the absence of localization in nodal line semimetals for long-range scalar disorder and a large range of disorder strengths. Using a continuum transfer matrix approach, we find that the conductivity in the plane and out of the plane of the nodal line increases with system size and disorder strength. We substantiate these findings by a perturbative calculation and show that the conductivity increases with disorder strength using the Kubo formula in the self-consistent Born approximation. We also find that the system remains metallic for vector disorder and that vector disorder can drive a transition from an insulating to a metallic regime. Our results demonstrate the absence of localization in a three-dimensional bulk system.
description: 11 pages, 10 figures; v2:accepted manuscript
Additional file 1 of Disrespect and abuse of women during the process of childbirth at health facilities in sub-Saharan Africa: a systematic review and meta-analysis
Creators: name: Kassa, Zemenu Yohannes
name: Berhan Tsegaye
name: Abebaw Abeje
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Table S1. Quality assessment checklist disrespect and abuse during childbirth and maternity care in Sub-Saharan Africa.
A survey of national and multi-national registries and cohort studies in juvenile idiopathic arthritis: challenges and opportunities
Creators: name: Beukelman, Timothy
name: Anink, Janneke
name: Berntson, Lillemor
name: Duffy, Ciaran
name: Ellis, Justine A
name: Glerup, Mia
name: Guzman, Jaime
name: Horneff, Gerd
name: Kearsley-Fleet, Lianne
name: Klein, Ariane
name: Klotsche, Jens
name: Magnusson, Bo
name: Minden, Kirsten
name: Munro, Jane E
name: Niewerth, Martina
name: Nordal, Ellen
name: Ruperto, Nicolino
name: Santos, Maria J
name: Schanberg, Laura E
name: Thomson, Wendy
name: Van Suijlekom-Smit, Lisette
name: Wulffraat, Nico
name: Hyrich, Kimme
Publisher: name: BioMed Central
Year: 2018

description: Background: To characterize the existing national and multi-national registries and cohort studies in juvenile idiopathic arthritis (JIA) and identify differences as well as areas of potential future collaboration. Methods: We surveyed investigators from North America, Europe, and Australia about existing JIA cohort studies and registries. We excluded cross-sectional studies. We captured information about study design, duration, location, inclusion criteria, data elements and collection methods. Results: We received survey results from 18 studies, including 11 national and 7 multi-national studies representing 37 countries in total. Study designs included inception cohorts, prevalent disease cohorts, and new treatment cohorts (several of which contribute to pharmacosurveillance activities). Despite numerous differences, the data elements collected across the studies was quite similar, with most studies collecting at least 5 of the 6 American College of Rheumatology core set variables and the data needed to calculate the 3-variable clinical juvenile disease activity score. Most studies were collecting medication initiation and discontinuation dates and were attempting to capture serious adverse events. Conclusion: There is a wide-range of large, ongoing JIA registries and cohort studies around the world. Our survey results indicate significant potential for future collaborative work using data from different studies and both combined and comparative analyses.
Predicting cooked beef consumer liking and sensory freshness using rapid evaporative ion spectrometry
Creators: name: Samarakoon, Chathurika S.
name: Realini Cujo, Carolina
name: Hamid, Nazimah
name: Staincliffe, Maryann
name: Ross, Alastair
name: Deb Choudhury, Santanu
name: Subbaraj, Arvind
name: Farouk, Mustafa
Publisher: name: AgResearch
Year: 2024
Subjects: classificationCode: 300602
subject: Food chemistry and food sensory science

description: Meat plays an important role in ready meals; however, the quality of ready meals deteriorates with storage time, and food loses its freshness condition due to various biochemical changes. The freshness perception of cooked meat leads to a higher consumer acceptability which directly influences consumers’ food choice and define the purchase of chilled ready meals. Therefore, predicting the eating quality and freshness of cooked meat is important for the ready meals industry. The objective of this study is to evaluate the use of Rapid Evaporative Ionization Mass Spectrometry (REIMS) to predict consumer liking and freshness rating of cooked beef stored at 4oC for 9 days. REIMS enables real-time evaluation of several complex features from a single measurement [1].
Additional file 1 of MOWLAS: NIED observation network for earthquake, tsunami and volcano
Creators: name: Aoi, Shin
name: Asano, Youichi
name: Kunugi, Takashi
name: Kimura, Takeshi
name: Uehira, Kenji
name: Takahashi, Narumi
name: Ueda, Hideki
name: Shiomi, Katsuhiko
name: Matsumoto, Takumi
name: Fujiwara, Hiroyuki
Publisher: name: figshare
Year: 2020
Subjects: subject: Geophysics
subject: FOS: Earth and related environmental sciences
subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences

description: Additional file 1: Figure S1. Hi-net station distribution with the NIED DMC and the ETMC system in the Sagami Bay. Figure S2. K-NET and KiK-net station distribution with the NIED DMC, the sub DMC, and the ETMC system in the Sagami Bay. Figure S3. F-net station distribution with the NIED DMC. Figure S4. Offshore station distribution of S-net, DONET, and the ETMC system in the Sagami Bay with the NIED DMC and landing stations. Figure S5. V-net station distribution with the NIED DMC.
REGULACIÓN DEL SEGURO MARÍTIMO  Y EL SEGURO SOBRE  RESPONSABILIDAD POR DAÑOS AMBIENTALES  EN LA PROVINCIA GRANMA.
Creators: name: Jorge Manuel Martinez Cumbrera
name: Lainiep Irina Cabrera Guerrra
name: Annia Calás  Nuñez
Publisher: name: Zenodo
Year: 2012

description:  Resumen. Con el presente trabajo se pretende informar  acerca de la institución del seguro específicamente,  del seguro marítimo y el seguro de responsabilidad por daños ambientales, especialmente el tratamiento que se le da en la provincia Granma, país de Cuba. La  esencia del mismo consiste en que parar crear medios especiales de reserva, que puedan servir de fuente para cubrir el daño material, causado por fenómenos naturales y nocivos, las organizaciones y las personas particulares, por medios de descuentos sistemáticos de sus medios, crean fondos de reserva. El mismo cuenta con dos capítulos.  Un primer epígrafe donde se analizan las generalidades del seguro marítimo y luego específicamente se investiga qué  tratamiento se la da al mismo en la provincia Granma.  Y  en el segundo epígrafe se analiza la responsabilidad ambiental, así como si en la provincia Granma existe el seguro de responsabilidad por daños ambientales.
Kambodscha 85/86: Aspekte zu Religion und Politik
Creators: name: Aschmoneit, Walter
Publisher: name: südostasien informationen
Year: 2018

description: Die religiösen Entwicklungen in Kamboscha sind sicher nach allgemeinen religionssoziologischen Gesichtspunkten zu betrachten, wie sie für andere Länder Asiens auch gelten; sie sind aber auch sehr spezifisch, denn die jüngste Geschichte Kambodschas unterscheidet sich qualitativ von der anderer Länder der Region. (...)
description: südostasien informationen, Bd. 2 Nr. 4 (1986): südostasien informationen
Approximation of sea surface velocity field by fitting surrogate two-dimensional flow to scattered measurements
Creators: name: Jakac, Karlo
name: Lanča, Luka
name: Sikirica, Ante
name: Ivić, Stefan
Publisher: name: arXiv
Year: 2024
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Optimization and Control (math.OC)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: In this paper, a rapid approximation method is introduced to estimate the sea surface velocity field based on scattered measurements. The method uses a simplified two-dimensional flow model as a surrogate model, which mimics the real submesoscale flow. The proposed approach treats the interpolation of the flow velocities as an optimization problem, aiming to fit the flow model to the scattered measurements. To ensure consistency between the simulated velocity field and the measured values, the boundary conditions in the numerical simulations are adjusted during the optimization process. Additionally, the relevance of quantity and quality of the scattered measurements is assessed, emphasizing the importance of the measurement locations within the domain as well as explaining how these measurements contribute to the accuracy and reliability of the sea surface velocity field approximation. The proposed methodology has been successfully tested in both synthetic and real-world scenarios, leveraging measurements obtained from Global Positioning System (GPS) drifters and high-frequency (HF) radar systems. The adaptability of this approach for different domains, measurement types, and conditions implies that it is suitable for real-world submesoscale scenarios where only an approximation of the sea surface velocity field is sufficient.
description: Literature overview extended
Vietnamesen im deutschen Exil
Creators: name: Phuong, Doan Minh
Publisher: name: südostasien informationen
Year: 2018

description: "Doan Minh Phuong ist eine von 25.000 Vietnamesen im deutschen Exil. Wir freuen uns, daß sie unserer Bitte entsprochen hat, einen Artikel für diese Ausgabe unserer Zeitung zu schreiben. Wir sind der Meinung, daß ihr sehr persönlich geschriebener Beitrag zu ihrer eigenen Geschichte und ihrem jetzigen Leben im Exil repräsentativ ist für viele in der BRD lebende Vietnamesen. (...)"
description: südostasien informationen, Bd. 2 Nr. 4 (1986): südostasien informationen
Additional file 2 of Disrespect and abuse of women during the process of childbirth at health facilities in sub-Saharan Africa: a systematic review and meta-analysis
Creators: name: Kassa, Zemenu Yohannes
name: Berhan Tsegaye
name: Abebaw Abeje
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2: Figure S1. Subgroup based on study population during childbirth and maternity care in Sub-Saharan Africa. Figure S2. The forest plot Prevalence of physical abuse during childbirth and maternity care in Sub-Saharan Africa. Figure S3. The forest plot Prevalence of non-confidential care during childbirth and maternity care in Sub-Saharan Africa. Figure S4. The forest plot Prevalence of abandonment care during childbirth and maternity care in Sub-Saharan Africa. Figure S5. The forest plot Prevalence of detention during childbirth and maternity care in Sub-Saharan Africa.