cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Designing molecular hybrids as novel breast cancer therapeutics
Creators: name: Shagufta
name: Ahmad, Irshad
name: Nasar, Noora Ali
name: Zerin, Sayma
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology

description: Designing molecular hybrids as novel breast cancer therapeutics
Sentido y función de la educación patrimonial en la Institución Educativa La Merced
Creators: name: Ramírez Galán, Jeisson Bautista
Publisher: name: Universidad Externado de Colombia
Year: 2023
Subjects: subject: Pedagogía - Enseñanza
subject: Patrimonio cultural - Aspectos sociales
subject: Educación - Estudios de caso
subject: Patrimonio
subject: Educación patrimonial
subject: Municipio de Mosquera
subject: Territorio
subject: Apropiación territorial

description: La educación patrimonial es una estrategia que permite conocer y reconocer la historia de diferentes territorios, relegándose a una sencilla transmisión de datos históricos y anecdóticos. Por esta razón, en este proyecto de investigación se llevó a cabo un proceso de problematizar la educación patrimonial y analizar cómo ésta puede contribuir en la construcción de territorio desde la voz y la acción de estudiantes de educación media de la Institución Educativa La Merced del municipio de Mosquera, y para el desarrollo de esta de estudiantes de grado décimo. A partir de la investigación cualitativa, enfocada _desde la investigación acción llevada a cabo con un grupo de semilleros de vigías del patrimonio de La Merced, se utilizaron diferentes instrumentos como la cartografía social y el grupo focal, para hablar y discutir sobre el patrimonio, su abordaje en el municipio entorno a la difusión, protección y conservación de los bienes patrimoniales y de esta forma identificar las estrategias que en la educación patrimonial contribuyen en la apropiación del territorio. En este sentido, se logró identificar acciones puntuales que permiten consolidar procesos de apropiación y empoderamiento de las comunidades entorno al patrimonio y que permite integrar a la comunidad entorno al reconocimiento de lo local.
description: The heritage education it' s a strategy to know and recognize the history of diferent territories relegated toan a simple transmisión of historical facts. Therefore, this research Project has to tries to problematise the heritage education and analize how this can contribute to built this territory from the student's voice and action in tenth grade, inmiddle education. From then qualitative research, focus on action research developed from hothouses in Heritage Watchers in La Merced, were used diferent research instruments like social maps, focus group, to talk and discuss about heritage, how to abord this at the town and how it setting broadcast, conservation and safeguard about heritage godos and this arrangement identify the heritage education strategies to contribute to territorial appropiation.
sj-pdf-5-vas-10.1177_1708538120963914 - Supplemental material for The oral health status of patients with peripheral vascular disorders: A systematic review
Creators: name: Almoosawy, Sayed Abdulmotaleb
name: McGowan, Mhairi
name: Hijazi, Karolin
name: Patey, Rona
name: Bachoo, Paul
name: Cherukara, George
Publisher: name: SAGE Journals
Year: 2020
Subjects: Cardiology

description: Supplemental material, sj-pdf-5-vas-10.1177_1708538120963914 for The oral health status of patients with peripheral vascular disorders: A systematic review by Sayed Abdulmotaleb Almoosawy, Mhairi McGowan Karolin Hijazi Karolin Hijazi, Rona Patey, Paul Bachoo and George Cherukara in Vascular
Mapeando el territorio, una propuesta pedagógica por la comprensión socio espacial desde el aula
Creators: name: Castrillón Cárdenas, John Blake Alexander
Publisher: name: Universidad Externado de Colombia
Year: 2023
Subjects: subject: Aprendizaje - Casos de estudio
subject: Pedagogía - Enseñanza
subject: Educación - Aspectos sociales
subject: Espacio
subject: Significado
subject: Territorio
subject: Aprendizaje
subject: Transposición didáctica

description: En este trabajo de investigación pedagógica, se presenta una propuesta de intervención didáctica, cuyo propósito es analizar las prácticas educativas en las aulas de la Institución Educativa Departamental Integral de Cabrera, por medio de estrategias que fortalezcan el mejoramiento de los procesos de enseñanza y aprendizaje de las ciencias sociales como un saber esencial, ya que relaciona el tiempo y el espacio, dimensiones que se interrelacionan a través de situaciones complejas o problemáticas y que a su vez son el objeto de estudio de esta área del conocimiento. A lo anterior, se le denomina la realidad social, es allí, en donde la enseñanza de la geografía, como disciplina social, abre la posibilidad de reflexionar sobre la construcción de ambientes de aprendizaje para la vida, por medio de herramientas socio espaciales que son eficaces en la dinamización de los procesos educativos, tales como los mapas conceptuales y las cartografías sociales que permiten la construcción de identidad y sentido de pertenencia con su espacio geográfico.
Estrategias de comprensión lectora y lectura crítica
Creators: name: García Latorre, José Alexander
Publisher: name: Universidad Externado de Colombia
Year: 2023
Subjects: subject: Pedagogía - Enseñanza
subject: Educación - Estudios de caso
subject: Lectura - Educación
subject: Lectura crítica
subject: Comprensión lectora
subject: Estrategias de comprensión lectora
subject: Secuencia didáctica
subject: Textos auténticos

description: Implementar en el aula una intervención pedagógica sobre estrategias de comprensión que se llevan a cabo en los momentos antes, durante y después de la lectura, aplicadas en textos auténticos, permitió enriquecer la práctica docente, ya que a una serie de actividades planeadas y desarrolladas estratégicamente se vinculó una reflexión constante, en aras de identificar, atender a las necesidades de los estudiantes y fortalecer su competencia comunicativa lectora a nivel crítico intertextual. En este sentido, este proyecto surgió como resultado de las necesidades de implementar en el aula prácticas de lectura que vayan más allá del análisis lingüístico y de la recuperación de la información y que fortalezcan la lectura crítica. Por esta razón, se consideró pertinente llevar a cabo una secuencia didáctica que incluyera la lectura de textos auténticos, tales como artículos periodísticos sobre internet y redes sociales, identificando, siguiendo y apropiando estrategias para los momentos antes, durante y después de la lectura, a través de un trabajo flexible de acuerdo con los intereses y el ritmo de aprendizaje de los estudiantes del grado décimo de la I.E.D. San Gabriel del municipio de Viotá Cundinamarca.
description: To implement in the classroom a pedagogical intervention on comprehension strategies that are carried out in the moments before, during and after reading, applied to authentic texts, allowed enriching the teaching practice, since a series of strategically planned and developed activities were linked to a constant reflection, in order to identify, meet the needs of students and strengthen their communicative reading competence at a critical intertextual level. In this sense, this project arose as a result of the need to implement reading practices in the classroom that go beyond linguistic analysis and information retrieval and strengthen critical reading. For this reason, it was considered pertinent to carry out a didactic sequence that included the reading of authentic texts, such as journalistic articles on the Internet and social networks, identifying, following and appropriating strategies for the moments before, during and after reading, through a flexible work according to the interests and learning rhythm of the tenth grade students of the I.E.D. San Gabriel of the municipality of Viotá Cundinamarca.
The role of environmental and healthcare-associated infections in Asia: Lessons learned from the coronavirus disease 2019 (COVID-19) pandemic
Creators: name: Ling, Moi Lin
name: Weber, David J.
name: Apisarnthanarak, Anucha
Publisher: name: Cambridge University Press (CUP)
Year: 2023

description:
Environmental cleaning and disinfection practices have been shown to reduce microorganism bioburden in the healthcare environment. Due to the coadministration of high-dose steroids and the prolonged duration of mechanical ventilation, coinfection with multi-drug-resistant organisms (MDROs) among coronavirus disease 2019 (COVID-19) patients is common in critical care patients, with a prolonged length of stay in critical care units. Furthermore, the rush of creating of negative-pressure units during the COVID-19 pandemic may have resulted in some outbreaks associated with molds such as Aspergillus and Zygomyces. In countries where they are prevalent, emerging fungal outbreaks, such as Candida auris outbreaks, have been reported. The control of MDROs among COVID-19 patients is also difficult, given the requirement for airborne plus contact isolation among these patients and the difficulty in wearing and changing personal protective equipment (PPE) in a critical care unit. The control of invasive fungal infections (IFIs) also requires practice of proper infection prevention and control (IPC) during construction and renovation. In this commentary, we provide evidence of how environment contribute to HAIs in Asia. We discuss how to properly disinfect and decontaminate healthcare environment, and we provide suggestions on how to improve air quality and water quality during COVID-19 pandemics.
An introduction and overview to the new SPNHC publication 'Best Practices in the Preservation and Management of Fluid-Persevered Biological Collections'.
Creators: name: Carter, Julian
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference poster on An introduction and overview to the new SPNHC publication 'Best Practices in the Preservation and Management of Fluid-Persevered Biological Collections'. by Principal Conservator Natural Science Julian Carter of Principal Conservator Natural Science National Museum Wales (UK) Cardiff United Kingdom for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
Synthesis and antimicrobial evaluation of hybrids methoxynaphthalene-N-acylhydrazones/1,3,4-oxadiazoles
Creators: name: Rozada, Andrew Matheus Frederico
name: Maçon, Camila
name: Santos, Jonathan L. A.
name: Ferreira, Raquel Manzotti
name: da Motta Dacome, Maria Luiza Fróes
name: Mendes, Rinaldo Poncio
name: Seixas, Flávio Augusto Vicente
name: Caleffi, Katiany
name: Basso, Ernani Abicht
name: de Freitas Gauze Bandoch, Gisele
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Paracoccidioidomycosis is a neglected tropical disease caused by the fungi Paracoccidoides spp. In cases of clinical manifestations involving the lung, its symptoms can be confused with tuberculosis, in addition to the possibility of patients presenting a co-infection between the two. Considering previous studies by our research group evaluating N-acylhydrazones and 1,3,4-oxadiazoles containing the 4-methoxynaphthalene ring, this work proposed the synthesis of new N-acylhydrazones and new 1,3,4-oxadiazoles containing the 2-methoxynaphthalene ring. Starting from the precursor block 2-methoxy-1-naphthaldehyde, N-acylhydrazones and their respective 1,3,4-oxadiazoles containing the 2-methoxynaphthalene ring were synthesized. The antifungal activity was evaluated against P. brasiliensis (P.b.18) and antimycobacterial activity against M. tuberculosis (H37Rv). The antimicrobial activity was tested for nine N-acylhydrazones and four 1,3,4-oxadiazoles in which structures showing anti-P.b. activity, highlighting the N-acylhyadrazone 5f and 1,3,4-oxadiazole 6f with MIC of 0.48 ug mL−1 and 1.95 ug mL−1, respectively, and substances with anti-M.tb. activity with MIC between 7.8 and 15.6 ug mL−1 (6a and 6b, respectively). New structures containing methoxynaphalene rings and phenol or substituted phenol or pyridine groups can be added to the chemolibrary of candidates for prototypes of drugs with antimicrobial activity against P.b.18 and H37Rv.
MSJ963880_supplemental_material – Supplemental material for Effect of mood and anxiety disorders on health care utilization in multiple sclerosis
Creators: name: Marrie, Ruth Ann
name: Walld, Randy
name: Bolton, James M
name: Jitender Sareen
name: Patten, Scott B
name: Singer, Alexander
name: Lix, Lisa M
name: Hitchon, Carol A
name: El-Gabalawy, Renée
name: Katz, Alan
name: Fisk, John D
name: Marriott, James J
name: Bernstein, Charles N
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences

description: Supplemental material, MSJ963880_supplemental_material for Effect of mood and anxiety disorders on health care utilization in multiple sclerosis by Ruth Ann Marrie, Randy Walld, James M Bolton, Jitender Sareen, Scott B Patten, Alexander Singer, Lisa M Lix, Carol A Hitchon, Renée El-Gabalawy, Alan Katz, John D Fisk, James J Marriott and Charles N Bernstein in Multiple Sclerosis Journal
Competencias emocionales; una apuesta por la resignificación de las dimensiones de la práctica docente
Creators: name: Garzón Molina, Juan Carlos
Publisher: name: Universidad Externado de Colombia
Year: 2022
Subjects: subject: Pedagogía - Enseñanza
subject: Personal docente - Estudios de caso
subject: Aprendizaje - Educación
subject: Competencias emocionales
subject: Práctica docente
subject: Gestión emocional
subject: Relación pedagógica

description: La escuela no reflexiona sobre la emocionalidad de sus equipos de trabajo y el maestro dentro de su práctica se encuentra interconectado con una variedad de relaciones que son propias de su ejercicio profesional, las cuales en ocasiones irrumpen en otros escenarios fuera del aula y quedan excluidos de la reflexión de la escuela, La gestión emocional y el efecto de esta en el accionar pedagógico de los maestros, es uno de los factores que facilitan el aprendizaje colegiado, la convivencia, el desarrollo humano y el clima institucional. El maestro no puede ser visto, meramente como un sujeto conocedor de competencias disciplinares, sino por el contrario desde su carácter integrador y holístico de las diferentes dimensiones que permean la relación pedagógica, el presente trabajo da muestra de una serie de acciones que contribuyeron al desarrollo de la dimensión personal, interpersonal e institucional en el colegio Santo Tomás Chía.
description: The school does not reflect on the emotional well-being of its teaching staff, and the teacher, within their practice, is interconnected with a variety of relationships that are specific to their professional exercise, which sometimes spill over into other scenarios outside the classroom and are excluded from the school's reflection. Emotional management and its effect on the pedagogical actions of teachers are one of the factors that facilitate collaborative learning, coexistence, human development, and institutional climate. The teacher cannot be seen merely as a subject knowledgeable in disciplinary competencies, but rather from their integrative and holistic character of the different dimensions that permeate the pedagogical relationship. This work demonstrates a series of actions that contributed to the development of personal, interpersonal, and institutional dimensions at the Santo Tomás Chía school.
Christians, Jews, and Judaism in the Eastern Mediterranean and Near East, c. 150–400 CE
Creators: name: Jacobs, Andrew
Publisher: name: Cambridge University Press
Year: 2022
Subjects: subject: Jews
subject: Church history--Primitive and early church
subject: Christianity
subject: Religion
subject: Civilization, Classical
subject: Interfaith relations
subject: History, Ancient

description: The institutional, social, and theological rise of an imperial-episcopal orthodoxy in the 4th-century Roman Empire transformed the productive, if not always genial, scriptural and ritual interactions among Jews and Christians in previous centuries into a discourse of theological difference, enabling violence and exclusion.
Role of Ag addition on the microscopic material properties of (Ag,Cu)(In,Ga)Se2 absorbers and their effects on losses in the open-circuit voltage of corresponding devices
Creators: name: Thomas, Sinju
name: Witte, Wolfram
name: Hariskos, Dimitrios
name: Gutzler, Rico
name: Paetel, Stefan
name: Kempa, Heiko
name: Maiberg, Matthias
name: Abou-Ras, Daniel
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 530

description: Ag alloying of Cu(In,Ga)Se2 (CIGSe) absorbers in thin-film solar cells leads to improved crystallization of these absorber layers at lower substrate temperatures than for Ag-free CIGSe thin films as well as to enhanced cation interdiffusion, resulting in reduced Ga/In gradients. However, the role of Ag in the microscopic structure–property relationships in the (Ag,Cu)(In,Ga)Se2 thin-film solar cells as well as a correlation between the various microscopic properties of the polycrystalline ACIGSe absorber and open-circuit voltage of the corresponding solar cell device has not been reported earlier. In the present work, we study the effect of Ag addition by analyzing the differences in the various bulk, grain-boundary, optoelectronic, emission, and absorption-edge properties of ACIGSe absorbers with that of a reference CIGSe absorber. By comparing thin-film solar cells with similar band-gap energies ranging from about 1.1 to about 1.2 eV, we were able to correlate the differences in their absorber material properties with the differences in the device performance of the corresponding solar cells. Various microscopic origins of open-circuit voltage losses were identified, such as strong Ga/In gradients and local compositional variations within individual grains of ACIGSe layers, which are linked to absorption-edge broadening, lateral fluctuations in luminescence-energy distribution, and band tailing, thus contributing to radiative VOC losses. A correlation established between the effective electron lifetime, average grain size, and lifetime at the grain boundaries indicates that enhanced nonradiative recombination at grain boundaries is a major contributor to the overall VOC deficit in ACIGSe solar cells. Although the alloying with Ag has been effective in increasing the grain size and the effective electron lifetime, still, the Ga/In gradients and the grain-boundary recombination in the ACIGSe absorbers must be reduced further to improve the solar-cell performance.
Development of indole hybrids for potential lung cancer treatment - part II
Creators: name: Huang, Shanshan
name: Xu, Zhi
name: Zhuang, Yafei
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Lung cancer has become the most prevalent cancer for the past three decades, and the 5-years survival rate of lung cancer is only ~20% nowadays. Chemotherapy is the mainstay of lung cancer therapy, especially for non-small cell lung cancer. However, drug resistance represents a principal cause of therapeutic failure in non-small cell lung cancer leading to therapeutic insensitivity, tumor recurrence, and disease progression. Indole hybrids have the potential to conquer drug resistance, enhance efficacy, reduce adverse events, and improve pharmacokinetic properties due to their capacity to inhibit multiple targets simultaneously. Moreover, indole hybrids osimertinib, mobocertinib, cediranib, and vizimpro are currently applied in clinics for lung cancer therapy, demonstrating that indole hybrids are valuable scaffolds in the treatment and eradication of lung cancer. This review provides a comprehensive overview of the evolving landscape of indole hybrids with the in vitro and in vivo efficacy against lung cancer, and the structure–activity relationships as well as mechanisms of action are also discussed, covering articles published from 2021 onward.
¿Cómo implementar una clínica jurídica de interés público para la formación de abogados comprometidos con la defensa de los derechos humanos, la democracia y la paz en Colombia?
Creators: name: Pérez Montoya, Juan José
Publisher: name: Universidad Externado de Colombia
Year: 2023
Subjects: subject: Derechos humanos - Aspectos sociales
subject: Responsabilidad social - Educación
subject: Pedagogía - Enseñanza
subject: Clínica jurídica
subject: Método clínico jurídico
subject: Educación jurídica
subject: Litigio estratégico

description: Esta investigación pretende generar conciencia en las facultades de Derecho en Colombia sobre la necesidad de implementar clínicas jurídicas como estrategia pedagógica multifuncional puesto que, a pesar de la Constitución Política de 1991 cambió el paradigma del formalismo jurídico al centrarse en los valores y principios constitucionales, las facultades de Derecho siguen formando abogados que no están preparados para enfrentar los retos sociales de una sociedad moderna, digital y desigual. Estos abogados reciben una educación que se reduce al campo teórico, y por ende, en muchos no desarrollan las habilidades prácticas necesarias para el ejercicio profesional. Las clínicas jurídicas ofrecen una solución a este problema, ya que permiten a los estudiantes resolver casos reales que impactan en la sociedad mientras desarrollan competencias y cualidades integrales. Además de cumplir una función pedagógica, las clínicas jurídicas cumplen una función social al refrendar la democracia, la paz y los derechos humanos. Para el desarrollo de la investigación, este texto se compone, además de la introducción, de otras cinco partes, así: (i) planteamiento del problema, (ii) marco referencial y normativo, (iii) diseño metodológico, (iv) análisis de resultados y discusión, y (v) conclusiones y reflexiones finales.
description: This research aims to raise awareness in law schools in Colombia about the need to implement legal clinics as a multifunctional pedagogical strategy. Even though the Political Constitution adopted in 1991 changed the paradigm of legal formalism by focusing on constitutional values and principles, law schools continue to train lawyers who are not prepared to face up the social challenges of a modern, digital and unequal society. Legal education is reduced to theoretical field, and thus, many students do not develop the needed skills for professional practice. Legal clinic education offers a solution to this problem, as it allows students to solve real cases that impact society. It also allows them to develop comprehensive qualities. In addition to fulfilling a pedagogical function, legal clinics fulfill a social function by endorsing democracy, peace and human rights. To develop the research, this text is composed by an introduction and five other parts: (i) problem statement, (ii) theoretical framework, (iii) methodology (iv) results and discussion, and (v) conclusions and recommendations
Una aproximación a la educación financiera en los estudiantes de grado 605 JT de la Institución Educativa Compartir
Creators: name: Parra Rojas, Kevin Ulises
Publisher: name: Universidad Externado de Colombia
Year: 2023
Subjects: subject: Pedagogía - Enseñanza
subject: Finanzas - Educación
subject: Competencia en educación - Estudios de caso
subject: Educación financiera
subject: Competencias financieras
subject: Intervención pedagógica
subject: Investigación acción

description: El presente documento tiene como objetivo mostrar los resultados de una intervención pedagógica en torno, al fortalecimiento de las competencias financieras en los estudiantes de grado 605 de la jornada tarde de la Institución Educativa Compartir - Soacha. De ahí que, la intervención parte de reconocer en la población objeto de estudio, los preconceptos asociados a la educación financiera, y en ese sentido implementar una propuesta que potencie en los estudiantes dichas competencias acordes con su nivel preconceptual. En el desarrollo y creación de la intervención pedagógica se establecen cuatro fases: diagnóstico, diseño, intervención y evaluación, que permiten evidenciar la coherencia investigativa a partir del enfoque y tipo que se enmarcan en la investigación - acción y en el análisis cualitativo de los resultados obtenidos.
description: This document has like objective show the results about pedagogical intervention in the context To the strengthening to the financial competences in the students of grade 605 of the afternoon shift of the INSTITUCION EDUCATIVA COMPARTIR-SOACHA from there that the intervention starts from recognize in the population like study object, the associate pre -knowledge to the financial education, in that order implement a proposal that empower in the students those competitives according to their pre knowledge. In the develop and creation of the pedagogical intervention sets out four fases: diagnosis, design, intervention and evaluation. That allows prove the investigative coherence from the approach and kind that frames in the action – investigation in the qualitative analysis from the scores get.
Additional file 1 of MetaPro: a scalable and reproducible data processing and analysis pipeline for metatranscriptomic investigation of microbial communities
Creators: name: Taj, Billy
name: Adeolu, Mobolaji
name: Xiong, Xuejian
name: Ang, Jordan
name: Nursimulu, Nirvana
name: Parkinson, John
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: Additional file 1: Fig. S1. Read relationships of HUMAnN3 and SAMSA2 against The Gold standard. Chord diagrams showing the relationships of the gold-standard annotated reads of the NOD mouse gut (A) and kimchi datasets (B) as they are processed by the HUMAnN3 and SAMSA2 pipelines. Each arc of the diagram is a category of reads. Each band joining 2 arcs represents the proportion of reads that map between categories. Many of the unidentified mouse gut reads in HUMAnN3 were identified as Parabacteroides ASF519. Similar to MetaPro, SAMSA2 identified a portion of the Parabacteroides ASF519 gold-standard reads to be Parabacteroides goldsteinii.  In the kimchi set, HUMAnN3 has more branching chords than MetaPro. SAMSA2 has a larger proportion of reads in Other organisms compared to MetaPro. In an ideal scenario, there would be a 1:1 relationship between the Gold-standard and the pipelines.
Procesos de lectura a través del uso de medios audiovisuales en estudiantes con discapacidad intelectual
Creators: name: Sánchez Alfonso, Lady Carolina
Publisher: name: Universidad Externado de Colombia
Year: 2023
Subjects: subject: Pedagogía - Enseñanza
subject: Aprendizaje - Aspectos sociales
subject: Lectuta - Estudios de caso
subject: Discapacidad intelectual
subject: Dispositivos básicos de aprendizaje
subject: Lectura
subject: Medios audiovisuales

description: Este trabajo investigativo, realizado como tesis de Maestría en Educación bajo el énfasis de investigación de aprendizaje de la lectoescritura y las matemáticas, tiene como objetivo de investigación analizar los procesos de lectura, mediados por el uso de medios audiovisuales, de los niños y niñas con discapacidad intelectual leve del programa de inclusión del colegio León de Greiff IED. Para el desarrollo de esta tesis se abordaron cuatro grandes categorías: discapacidad intelectual, dispositivos básicos de aprendizaje, lectura y medios audiovisuales. En relación con la metodología de investigación, se lleva a cabo bajo el enfoque cualitativo y la investigación acción, a partir de la aplicación de instrumentos de recolección de información como diarios de campo, implementación de pruebas adaptadas a través de diferentes medios audiovisuales y matrices de análisis.
description: This research work, carried out as a Master’s thesis in Education under the emphasis of learning research of literacy and mathematics, aims to analyze the processes of reading, mediated by the use of audiovisual media, of children with mild intellectual disabilities from the León de Greiff IED inclusion program. For the development of this thesis four main categories were addressed: intellectual disability, basic learning devices, reading and audiovisual media. In relation to research methodology, it is carried out under the qualitative approach and action research, from the application of information gathering instruments such as field diaries, implementation of tests adapted through different audiovisual media and analysis matrices.
Adverse obstetric outcomes after breast cancer diagnosis : an observational database study in Germany
Creators: name: Scholz, Anna
name: Au, Alexandra
name: Gutsfeld, Raphael
name: Dijkstra, Tjeerd Maarten Hein
name: Dannehl, Dominik
name: Haßdenteufel, Kathrin
name: Hahn, Markus
name: Hawighorst-Knapstein, Sabine
name: Chaudhuri, Ariane
name: Bauer, Armin
name: Wallwiener, Markus
name: Brucker, Sara
name: Hartkopf, Andreas
name: Wallwiener, Stephanie
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 610

description: Background/Objectives: Breast cancer may negatively affect later pregnancy and childbirth. We aimed to analyze the impact of previous breast cancer on obstetric outcomes in postdiagnosis pregnancies. Methods: Insurance claims data in Southern Germany were used to identify breast cancer (BC) survivors with at least one subsequent delivery after cancer diagnosis between 2010 and 2020. In total, 74 BC survivors were compared to 222 age-matched controls with frequency matching on their age at their postdiagnosis delivery. Results: Endocrine therapy was associated with a significantly lower probability of birth compared to BC survivors without endocrine therapy (HR 0.36; 95% CI 0.18–0.53; p < 0.0001). The risks of preterm birth, low birth weight (LBW), gestational diabetes, hypertensive disorders, and cesarean section were not significantly increased among BC survivors compared to healthy controls. BC survivors were at an increased risk for a small-for-gestational-age (SGA) fetus (OR 3.24; 95% CI 1.17–8.97, p = 0.03). Delivery in less than 2 years after diagnosis increased the risk for SGA (OR 5.73; 95% CI 1.37–24.02, p = 0.03) and LBW (OR 4.57; 95% CI 1.32–15.87, p = 0.02). Conclusions: Our findings are encouraging regarding the risks of preterm delivery, gestational diabetes, hypertensive disorders, and cesarean section to women who consider pregnancy after BC. Delivery in less than 2 years after diagnosis was associated with an increased risk for SGA and LBW.
Creación de textos narrativos para fortalecer la producción escrita
Creators: name: Nieto Poveda, Leydi Constanza
Publisher: name: Universidad Externado de Colombia
Year: 2023
Subjects: subject: Educación - Investigación
subject: Escritura - Educación
subject: Pedagogía - Enseñanza
subject: Producción escrita
subject: Textos narrativos
subject: Secuencia didáctica
subject: Trabajo cooperativo

description: El trabajo de grado se enmarca en la implementación de una secuencia didáctica, cuya finalidad es fortalecer la producción escrita de los estudiantes de grado cuarto de la Institución Educativa Departamental San Gabriel, mediante la creación de textos narrativos a través del trabajo cooperativo. Dicha secuencia concibe la escritura como un proceso reflexivo, que se desarrolla mediante la planeación, escritura y reescritura, lo cual enriquece las producciones escritas de los estudiantes en las diversas fases. En este sentido, la construcción de textos narrativos favorece el conocimiento de sí mismo, las competencias lingüísticas, los fundamentos del lenguaje e incentiva el interés por la lectura, debido a que esta tipología textual hace parte de la cotidianidad de los estudiantes, siendo así un referente en cuanto a su estructura, contenido y propósito comunicativo.
description: The degree work is part of the implementation of a didactic sequence, which porpose is to strengthen the written production of fourth grade students of the Institución Educativa Departamental San Gabriel, through the creation of narrative texts through cooperative work. This sequence conceives writing as a reflective process, which is developed through planning, writing and rewriting, which enriches the written productions of students in various phases. In this sense, the construction of narrative texts favors self-knowledge, linguistic skills, language fundamentals and encourages interest in reading, because this textual typology is part of the daily life of students, thus being a reference in terms of its structure, content and communicative purpose.
Enseñanza de la escritura por medio de textos informativos : el monstruo de las emociones
Creators: name: (:Unkn) Unknown
Publisher: name: Universidad Externado de Colombia
Year: 2023
Subjects: subject: Pedagogía - Enseñanza
subject: Escritura - Metodología
subject: Educación - Aspectos sociales
subject: Escritura
subject: Composición escrita
subject: Fases de la escritura
subject: Textos informativos
subject: Formalización de la escritura

description: El presente trabajo, corresponde al proceso de investigación del trabajo de grado de la maestría en educación, en donde se propuso una estrategia didáctica cuyo objetivo fue implementar una secuencia didáctica que potenciara el proceso de enseñanza de la escritura de textos informativos de los estudiantes de primer grado del colegio INEM Francisco de Paula Santander, a través del tema de las emociones, en donde el acto comunicativo de la galería de las producciones escritas de los estudiantes fue el que jalonó estos procesos de composición escrita. La secuencia didáctica: “El monstruo de las emociones: Aprendizaje de la escritura”, cuyo propósito de aprendizaje fue que el estudiante realizara producciones escritas (de acuerdo con su fase de escritura) en donde identificara, expresara y manejara sus propias emociones, para una galería, la cual permitió socializar las producciones escritas del trabajo realizado. Como conclusión, se presenta el impacto de la intervención pedagógica al implementar una secuencia didáctica, la cual potenció el proceso de enseñanza de la escritura de textos informativos de los estudiantes del colegio, al producir textos escritos informativos; y se plantearon propuestas de sostenibilidad, para que el proceso de enseñanza y aprendizaje se continúe transformando y mejorando.
description: The present document is to process of the investigation for a Magister Education degree work, this one proposed a didactic strategy, the main goal was to implement a didactic sequence that would potentiate the teaching process of writing informative texts of the first grade students from the INEM Francisco de Paula Santander, through the topic of emotions, the communicative act of the gallery of the written productions of the students was the one that stimulated these processes of written composition. The didactic sequence: "The emotions monster. Learning to write", its learning purpose was for the student wrote productions (according to their writing phase) where they identified, expressed and managed their own emotions, for the gallery, this allowed to socialize the written productions of the work done. In conclusion, the impact of the pedagogical intervention is presented to implement a didactic sequence, this potentiated the teaching process of writing informative texts for school students, when they produced informative written texts; and sustainability proposals were that the teaching and learning process continues to transform and improve.
Unlocking the power of imidazoquinolines: recent advances in anticancer and immunotherapeutic strategies
Creators: name: R, Ranjini Jenifer
name: Choudhury, Badruzzaman
name: Alam, Mohammed Mujahid
name: Mm, Balamurali
name: Chanda, Kaushik
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Science Policy

description: The challenges in drug discovery aiming to mitigate cancer progression are the thrust area of scientific research for several decades. Since the advent of heterocyclic chemistry, drug discovery programs have made significant achievements that lead to the development of numerous drugs with broad spectrum of potencies, contributing to both diagnostic and therapeutic advancements. Till date, efforts to discover more potent and efficient drug candidates are underway to minimize adverse side effects of existing chemotherapeutics. In view of the above, small-molecule agonists that can interact with different immune modulators like toll like receptor-7 (TLR-7) and TLR-8 are being investigated and explored. These candidates are expected to display profound effect on anti-tumoral activity by enhancing the production of proinflammatory cytokines. Recently, numerous imidazoquinoline derivatives with proven TLR agonist activities have emerged as promising anticancer therapeutics. With advancements in technology and the evolution of new scopes in drug discovery, different strategies are being adopted, particularly with the help of nanotechnology, immune-technology, combination drug chemistry, etc., to curb the progression of various types of cancers. Herein, the novel strategies for cancer therapeutics with imidazoquinolines reported in the last 5 years, their structure-activity relationship along with important synthetic schemes for important TLR agonists, are discussed.
Design and synthesis of thiadiazoles as anticancer, apoptotic, and VEGFR-2 inhibitors
Creators: name: Elgammal, Walid E.
name: Elkady, Hazem
name: Dahab, Mohammed A.
name: Mahdy, Hazem A.
name: Hagras, Mohamed
name: Nofal, Ahmed
name: Alsfouk, Bshra A.
name: Elkaeed, Eslam B.
name: Eissa, Ibrahim H.
name: Metwaly, Ahmed M.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Biochemistry
Medicine
Cell Biology
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Developmental Biology
Cancer
Hematology

description: Vascular endothelial growth factor receptor (VEGFR-2) inhibitors are critical in cancer therapy due to their role in suppressing tumor angiogenesis. Herein, we report a new series of thiadiazole-based derivatives as potential VEGFR-2 inhibitors with promising anticancer activity. The synthesized compounds were evaluated for anti-proliferative activity against human cancer cell lines (HCT-116, MCF-7, and HepG-2), and WI-38 as normal cells. Sorafenib was used as a reference drug. VEGFR-2 inhibitory activity was determined, followed by cell cycle analysis, apoptosis assays, Q-RT-PCR analysis, and wound-healing assays. In silico molecular docking was conducted to explore binding interactions. Among the tested compounds, 13b exhibited potent anti-proliferative activity (IC50: 3.98–11.81 µM) and strong VEGFR-2 inhibition (IC50: 41.51 nM), surpassing sorafenib (IC50: 53.32 nM). Cell cycle analysis revealed that 13b induced G2/M phase arrest in MCF-7 cells. Apoptosis levels increased from 2% to 52%, accompanied by a > 12-fold rise in the Bax/Bcl-2 ratio and activation of caspase-8/9. Additionally, 13b significantly suppressed MCF-7 cell migration, with only 5.28% wound closure. In silico studies confirmed its strong VEGFR-2 binding interactions. Thiadiazole-based derivatives, particularly compound 13b, exhibit potent VEGFR-2 inhibition, anti-proliferative effects, apoptosis induction, and anti-migratory activity, supporting their potential as promising anticancer agents.
An introduction to the marine invertebrate wet collections at National Museums Scotland
Creators: name: Ware, Fiona
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference oral presentation on An introduction to the marine invertebrate wet collections at National Museums Scotland by Curator Of Invertebrate Biology Fiona Ware of Curator Of Invertebrate Biology National Museums Scotland Edinburgh United Kingdom for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
Morphologically and compositionally controlled Cs2SbBr6 by Bi and Ag substitution
Creators: name: Frebel, Alexander
name: Yoon, Songhak
name: Neguse, Samuel Meles
name: Jöckel, Dennis Michael
name: Widenmeyer, Marc
name: Ebbinghaus, Stefan
name: Balke-Grünewald, Benjamin
name: Weidenkaff, Anke
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 540

description: Morphology-controlled Cs2SbBr6 crystals are synthesized by Bi- and Ag-substitution of the precursor solution. X-ray diffraction (XRD) together with Raman spectroscopy confirms the lattice tilting and symmetry changes with the dominant appearance of higher index facets by Bi substitution. Ag substitution does not induce crystal symmetry changes in the Cs2BBr6 (B = Sb or Bi) phase, but results in highly defective structures hindering the formation of a smooth surface during the crystal growth. Successful substitution of Bi and limited substitution of Ag into Cs2SbBr6 is also confirmed by energy dispersive X-ray spectroscopy (EDX). This research provides design principles and practical examples of how to control the morphology of Cs2SbBr6 crystals with structural defects and multiphase formation.
Diethylzinc-Amylates – Selective Halogen-Zinc Exchange Reagents at Room-Temperature
Creators: name: Didier, Dorian
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 340503
subject: Organic chemical synthesis

description: Supporting information for manuscript entitled:Diethylzinc-Amylates – Selective Halogen-Zinc Exchange Reagents at Room-Temperature
title: Syntheses and structural confirmation of stereoisomers and various isotopologues of tetrahydromethyltestosterone
Creators: name: Steff, Jakob
name: Maria Kristina, Parr
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: anabolic androgenic steroid
subject: synthesis
subject: GC-MS
classificationCode: 543
subject: Analytische Chemie
classificationCode: 547
subject: Organische Chemie

description: This is an overview of the syntheses and structural conformation of in-house synthesized compounds. These compounds belong to the group of sereoisomers of metabolites of anabolic androgenic steroids and have been used in different studies in our working group.
supplementary_data – Supplemental material for 3D-printable zwitterionic nano-composite hydrogel system for biomedical applications
Creators: name: Sällström, Nathalie
name: Capel, Andrew
name: Lewis, Mark P
name: Engstrøm, Daniel S
name: Martin, Simon
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Supplemental material, supplementary_data for 3D-printable zwitterionic nano-composite hydrogel system for biomedical applications by Nathalie Sällström, Andrew Capel, Mark P Lewis, Daniel S Engstrøm and Simon Martin in Journal of Tissue Engineering
Use of complementary and alternative medicine in patients with chronic liver diseases in Germany : a multicentric observational study
Creators: name: Gittinger, Fleur Sophie
name: Rahnfeld, Anna
name: Lacruz, Elena
name: Zipprich, Alexander
name: Lammert, Frank
name: Ripoll, Cristina
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 610

description: Background: The use of Complementary and alternative medicine (CAM) in chronic liver disease (CLD) patients in Germany is unknown. This study investigated the frequency of CAM use and associated sociodemographic, clinical and personality factors in CLD patients in Germany. Methods: This is a cross-sectional multicenter study of CLD patients attending liver outpatient clinics of university hospitals in Halle(-Saale) and Homburg between 2015 and 2017. Dedicated questionnaires recorded CAM use, sociodemographic and personality factors (evaluated with the “Big five” model, “Hospital Anxiety and Depression”-, “Multidimensional Health Locus of Control”- score). Uni- and multivariate analyses assessed factors associated to CAM use. Results: Overall 378 patients were recruited, 92 (24.3%) reported to CAM use. On univariate analysis, female CAM users were older (p = 0.001) and more physically active (p = 0.002), male CAM users more often used homeopathy (p = 0.000), actively promoted their health (p = 0.010) or had UDC in their medication (p = 0.004). Logistic regression analysis adjusted for personality factors showed significant association of age, physical exercise (females) and satisfaction with alternative medicine (females, males) to CAM use. Conclusions: CAM use is prevalent among CLD patients in Germany and is significantly associated to satisfaction with alternative medicine (females, males), physical exercise and older age (females). Doctors should actively inquire CLD patients about CAM use, as hepatotoxicity or interaction with medication can occur.
MAHMUDXOʻJA BEHBUDIY VA UNING JADIDCHILIK G'OYALARI XUSUSIDA
Creators: name: Nizomiddinxoʻjayev, Otabek
Publisher: name: Zenodo
Year: 2024

description: Maqolada maʼrifatparvar ijodkor Mahmudxoʻja Behbudiy va uning jadidchilik qarashlari, ilgʻor gʻoyalari hamda jadidchilik harakatining ijtimoiy, maʼnaviy hayotdagi amaliy faoliyati, adabiy muhitga taʼsiri masalasi maʼlumotlar asosida ilmiy-amaliy jihatdan tahlilga tortilgan.
Exploring the metabolic profile of A. baumannii for antimicrobial development using genome-scale modeling
Creators: name: Leonidou, Nantia
name: Xia, Yufan
name: Friedrich, Lea
name: Schütz, Monika
name: Dräger, Andreas
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 570

description: With the emergence of multidrug-resistant bacteria, the World Health Organization published a catalog of microorganisms urgently needing new antibiotics, with the carbapenem-resistant Acinetobacter baumannii designated as “critical”. Such isolates, frequently detected in healthcare settings, pose a global pandemic threat. One way to facilitate a systemic view of bacterial metabolism and allow the development of new therapeutics is to apply constraint-based modeling. Here, we developed a versatile workflow to build high-quality and simulation-ready genome-scale metabolic models. We applied our workflow to create a metabolic model for A. baumannii and validated its predictive capabilities using experimental nutrient utilization and gene essentiality data. Our analysis showed that our model iACB23LX could recapitulate cellular metabolic phenotypes observed during in vitro experiments, while positive biomass production rates were observed and experimentally validated in various growth media. We further defined a minimal set of compounds that increase A. baumannii’s cellular biomass and identified putative essential genes with no human counterparts, offering new candidates for future antimicrobial development. Finally, we assembled and curated the first collection of metabolic reconstructions for distinct A. baumannii strains and analyzed their growth characteristics. The presented models are in a standardized and well-curated format, enhancing their usability for multi-strain network reconstruction.