cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A REVIEW ON ANALYTICAL METHODS FOR GLIBENCLAMIDE BY HPLC
Creators: name: Banothu Bhadru*, Tadikonda Rama Rao, Sappidi Harshitha
Publisher: name: Zenodo
Year: 2024

description: Glibenclamide, or glyburide, is a second-generation sulfonylurea that effectively lowers blood sugar in type-2 diabetes patients who do not require insulin. Symptoms of low blood sugar may include excessive thirst, fatigue, dizziness, increased hunger, and blurred vision. It should be used alongside a proper diet and exercise and can be combined with other diabetes treatments, but is not suitable for type-1 diabetes. Common side effects include nausea, heartburn, weight gain, and bloating, with a notable risk of hypoglycemia and angioedema. Its use is generally discouraged during pregnancy but may be acceptable while breastfeeding. Glibenclamide stimulates insulin secretion from the pancreas and is contraindicated in patients with sulfonamide allergies, type-1 diabetes, ketoacidosis, or severe renal or hepatic impairment. This article also discusses validated analytical techniques, particularly High Performance Liquid Chromatography (HPLC), for quantifying Glibenclamide in pharmaceutical formulations.

Key words: Glibenclamide, HPLC, Accuracy, Precision, ICH, Validation
Inhibition of soluble antigen-induced T cell proliferation by warm-reactive antibodies to activated T cells in systemic lupus erythematosus.
Creators: name: Yamada, A
name: Winfield, J B
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1984

description: Les observations concernant les effets suppresseurs des anticorps anti-blastes T du sérum des lupus érythémateux disséminé sur la réponse des cellules T à l'anatoxine tétanique devraient mieux faire comprendre les mécanismes du dysfonctionnement in vivo des cellules T dans cette affection et d'autres affections immunologiques.
Time Series Clustering with an EM algorithm for Mixtures of Linear Gaussian State Space Models
Creators: name: Umatani, Ryohei
name: Imai, Takashi
name: Kawamoto, Kaoru
name: Kunimasa, Shutaro
Publisher: name: arXiv
Year: 2022
Subjects: subject: Machine Learning (cs.LG)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Statistics Theory (math.ST)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: In this paper, we consider the task of clustering a set of individual time series while modeling each cluster, that is, model-based time series clustering. The task requires a parametric model with sufficient flexibility to describe the dynamics in various time series. To address this problem, we propose a novel model-based time series clustering method with mixtures of linear Gaussian state space models, which have high flexibility. The proposed method uses a new expectation-maximization algorithm for the mixture model to estimate the model parameters, and determines the number of clusters using the Bayesian information criterion. Experiments on a simulated dataset demonstrate the effectiveness of the method in clustering, parameter estimation, and model selection. The method is applied to real datasets commonly used to evaluate time series clustering methods. Results showed that the proposed method produces clustering results that are as accurate or more accurate than those obtained using previous methods.
Persistent Identifier (PID) role in supporting open research infrastructure
Creators: name: Gurdal, Gultekin
Publisher: name: Zenodo
Year: 2023
Subjects: DataCite
PID
DOI
OpenResearch
Türkiye
DataCiteGAP
webinar

description: Turkish research institutions produce various research outputs and resources such as datasets, theses and protocols. These outputs do not receive the best recognition and visibility they deserve. Adopting persistent identifiers (PIDs) can increase the discoverability of these outputs and promote reusability by sharing them with the broader research community.In his presentation, Gultekin Gurdal explains persistent identifier (PID) role in supporting open research infrastructure. 
A recording of the talk can be found here: https://www.youtube.com/watch?v=RvqKUFeypT0&t=98s
Magnetic signatures on mixed-mode frequencies. II. Period spacings as a probe of the internal magnetism of red giants
Creators: name: Bugnet, L.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Theoretical works have looked into the various topologies and amplitudes, as well as the stability of the magnetic field that is expected to be present in the radiative interior of stars evolving after the main sequence. Such internal magnetic fields have never been observed in evolved stars. As a result, there is a major piece missing from our global picture of stars as dynamical bodies. Asteroseismology opened a window onto stellar internal dynamics, as oscillation frequencies, amplitudes, and lifetimes are affected by processes that are taking place inside the star. In this scope, magnetic signatures on mixed-mode frequencies have recently been characterized, but the task of detection remains challenging as the mixed-mode frequency pattern is highly complex and affected by rotational effects, while modes of different radial orders are often intertwined. In this work, we aim to build a bridge between theoretical prescriptions and complex asteroseismic data analysis to facilitate a future search and characterization of internal magnetism with asteroseismology. We investigate the effect of magnetic fields inside evolved stars with solar-like oscillations on the estimation of the period spacing of gravity-mode components of simulated mixed gravito-acoustic modes. We derived a new corrected stretching function of the power spectrum density to account for the presence of magnetic signatures on their frequencies. We demonstrate that the strong dependency of the amplitude of the magnetic signature with mixed-mode frequencies leads to biased estimates of period spacings towards lower values. We also show that a careful analysis of the oscillation frequency pattern through various period spacing estimates and across a broad frequency range might lead to the first detection of magnetic fields inside red giants and at the same time, we adjust the measured value of gravity-mode period spacing.
description: 17 pages, 7 figures, 1 table, Accepted for publication in A&A
Spontaneous emission and quantum discord: comparison of Hilbert-Schmidt and trace distance discord
Creators: name: Jakobczyk, Lech
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Hilbert - Schmidt and trace norm geometric quantum discord are compared with regard to their behavior during local time evolution. We consider the system of independent two - level atoms with time evolution given by the dissipative process of spontaneous emission. It is explicitly shown that the Hilbert - Schmidt norm discord has nonphysical properties with respect to such local evolution and cannot serve as a reasonable measure of quantum correlations and the better choice is to use trace norm discord as such a measure.
Phase structure and real-time dynamics of the massive Thirring model in 1+1 dimensions using the tensor-network method
Creators: name: Bañuls, Mari Carmen
name: Cichy, Krzysztof
name: Hung, Hao-Ti
name: Kao, Ying-Jer
name: Lin, C. -J. David
name: Lin, Yu-Ping
name: Tan, David T. -L.
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We present concluding results from our study for zero-temperature phase structure of the massive Thirring model in 1+1 dimensions with staggered regularisation. Employing the method of matrix product states, several quantities, including two types of correlators, are investigated, leading to numerical evidence of a Berezinskii-Kosterlitz-Thouless phase transition. Exploratory results for real-time dynamics pertaining to this transition, obtained using the approaches of variational uniform matrix product state and time-dependent variational principle, are also discussed.
description: 7 pages, 4 figures, contribution to the 37th International Symposium on Lattice Field Theory (LATTICE2019), 16-22 June 2019, Wuhan, China
Aluminum doping improves the energetics of lithium, sodium, and magnesium storage in silicon
Creators: name: Legrain, Fleur
name: Manzhos, Sergei
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: While Si is an effective insertion type anode for Li-ion batteries, crystalline Si has been shown to be unsuitable for Na and Mg storage due, in particular, to insufficient binding strength. It has recently been reported that Si nanowires could be synthesized with high-concentration (several atomic %) and dispersed Al doping. Here we show based on density functional theory calculations that Al doping significantly improves the energetics for Na and Mg insertion, specifically, making it thermodynamically favored versus vacuum reference states. For high Al concentrations, the energy of Mg in Al-doped Si approaches the cohesive energy of Mg. However, the migration barriers for the diffusion of Li (0.57-0.70 eV), Na (1.07-1.19 eV) and Mg (0.97-1.18 eV) in Al-doped Si are found to remain about as high as in pure Si, likely preventing effective electrochemical sodiation and magnesiation.
Antarctic Time-Variable Regional Gravity Field Model Derived from Satellite Line-of-Sight Gravity Differences and Spherical Cap Harmonic Analysis
Creators: name: Feizi, Mohsen
name: Raoofian Naeeni, Mehdi
name: Flury, Jakob
Publisher: name: Basel : MDPI
Year: 2023
Subjects: subject: LGD
subject: SCHA
subject: time-variable gravity model
subject: GFO
subject: L2 JPL
subject: Dewey Decimal Classification::600 | Technik::620 | Ingenieurwissenschaften und Maschinenbau

description: This study focuses on the development of a time-variable regional geo-potential model for Antarctica using the spherical cap harmonic analysis (SCHA) basis functions. The model is derived from line-of-sight gravity difference (LGD) measurements obtained from the GRACE-Follow-On (GFO) mission. The solution of a Laplace equation for the boundary values over a spherical cap is used to expand the geo-potential coefficients in terms of Legendre functions with a real degree and integer order suitable for regional modelling, which is used to constrain the geo-potential coefficients using LGD measurements. To validate the performance of the SCHA, it is first utilized with LGD data derived from a L2 JPL (Level 2 product of the Jet Propulsion Laboratory). The obtained LGD data are used to compute the local geo-potential model up to Kmax = 20, corresponding to the SH degree and order up to 60. The comparison of the radial gravity on the Earth’s surface map across Antarctica with the corresponding radial gravity components of the L2 JPL is carried out using local geo-potential coefficients. The results of this comparison provide evidence that these basis functions for Kmax = 20 are valid across the entirety of Antarctica. Subsequently, the analysis proceeds using LGD data obtained from the Level 1B product of GFO by transforming these LGD data into the SCHA coordinate system and applying them to constrain the SCHA harmonic coefficients up to Kmax = 20. In this case, several independent LGD profiles along the trajectories of the satellites are devised to verify the accuracy of the local model. These LGD profiles are not employed in the inverse problem of determining harmonic coefficients. The results indicate that using regional harmonic basis functions, specifically spherical cap harmonic analysis (SCHA) functions, leads to a close estimation of LGD compared to the L2 JPL. The regional harmonic basis function exhibits a root mean square error (RMSE) of 3.71 × 10−4 mGal. This represents a substantial improvement over the RMSE of the L2 JPL, which is 6.36 × 10−4 mGal. Thus, it can be concluded that the use of local geo-potential coefficients obtained from SCHA is a reliable method for extracting nearly the full gravitational signal within a spherical cap region, after validation of this method. The SCHA model provides significant realistic information as it addresses the mass gain and loss across various regions in Antarctica.
Affinity-labeled plasma somatomedin-C/insulinlike growth factor I binding proteins. Evidence of growth hormone dependence and subunit structure.
Creators: name: D'Ercole, A J
name: Wilkins, J R
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1985

description: La protéine 12 liant à la somatomédine-C (In-C) dépendant de la STH, représentée par le complexe d'un PM de 100000 est composée d'espèces plus petites, comme par exemple les complexes d'un p.m. de 135000, 110000, 80000, 50000 et 28000, 24000. Chacun des complexes représenterait un oligomère composé de promoteurs d'un p.m. de 28000, 24000. L'espèce de p.m. 43000, 35000 ne dépend pas de la STH et semble représenter un type différent de protéine se liant à la somatomédine.
Spreading dynamics of a droplet impacting a sphere
Creators: name: Long, Ming
name: Hasanyan, Jalil
name: Jung, Sunghwan
Publisher: name: arXiv
Year: 2022
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: In nature, high-speed rain drops often impact and spread on curved surfaces e.g. tree leaves. Although a drop impact on a surface is a traditional topic for industrial applications, drop-impact dynamics on curved surfaces in natural situations are less known about. In the present study, we examine the time-dependent spreading dynamics of a drop onto a curved hydrophobic surface. We also observed that a drop on a curved surface is spreads farther than one on a flat surface. To understand the spreading dynamics, a new analytical model is developed based on volume conservation and temporal energy balance. This model converges to previous models at the early stage and in the final stage of droplet impact. We compared the new model with measured spreading lengths on various curved surfaces and impact speeds, which resulted in good agreement.
Non-Markovian dynamics of a single-mode cavity strongly coupled to an inhomogeneously broadened spin ensemble
Creators: name: Krimer, Dmitry O.
name: Putz, Stefan
name: Majer, Johannes
name: Rotter, Stefan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We study the dynamics of a spin ensemble strongly coupled to a single-mode resonator driven by external pulses. When the mean frequency of the spin ensemble is in resonance with the cavity mode, damped Rabi oscillations are found between the spin ensemble and the cavity mode which we describe very accurately, including the dephasing effect of the inhomogeneous spin broadening. We demonstrate that a precise knowledge of this broadening is crucial both for a qualitative and a quantitative understanding of the temporal spin-cavity dynamics. On this basis we show that coherent oscillations between the spin ensemble and the cavity can be enhanced by a few orders of magnitude, when driving the system with pulses that match special resonance conditions. Our theoretical approach is tested successfully with an experiment based on an ensemble of negatively charged nitrogen-vacancy (NV) centers in diamond strongly coupled to a superconducting coplanar single-mode waveguide resonator.
description: 15 pages, 13 figures
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 4 (37 a)]
Creators: name: Albertinus
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1308
Subjects: subject: Sonstige geistliche Aussteller
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Albertinus, Praepositus und Rector der Kirche St. Cataldi in Cremona, und weitere Geistliche dieser Kirche beschließen, zu dessen besserer Nutzung ein Stück Land, gelegen in Braida nahe der Kirche St. Simonis et Judae, zu verpachten.
Linear Response for a Family of Self-Consistent Transfer Operators
Creators: name: Sélley, Fanni M.
name: Tanzi, Matteo
Publisher: name: arXiv
Year: 2020
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: We study a system of all-to-all weakly coupled uniformly expanding circle maps in the thermodynamic limit. The state of the system is described by a probability measure and its evolution is given by the action of a nonlinear operator, also called a self-consistent transfer operator. We prove that when the coupling is sufficiently small, the system has a unique stable state that satisfies a linear response formula when varying the coupling strength.
description: Electronic copy of final peer-reviewed manuscript accepted for publication
Genesis and Coronal-jet-generating Eruption of a Solar Minifilament Captured by IRIS Slit-raster Spectra
Creators: name: Panesar, Navdeep K.
name: Tiwari, Sanjiv K.
name: Moore, Ronald L.
name: Sterling, Alphonse C.
name: De Pontieu, Bart
Publisher: name: arXiv
Year: 2022
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present the first IRIS Mg II slit-raster spectra that fully capture the genesis and coronal-jet-generating eruption of a central-disk solar minifilament. The minifilament arose in a negative-magnetic-polarity coronal hole. The Mg II spectroheliograms verify that the minifilament plasma temperature is chromospheric. The Mg II spectra show that the erupting minifilament's plasma has blueshifted upflow in the jet spire's onset and simultaneous redshifted downflow at the location of the compact jet bright point (JBP). From the Mg II spectra together with AIA EUV images and HMI magnetograms, we find: (i) the minifilament forms above a flux cancelation neutral line at an edge of a negative-polarity network flux clump; (ii) during the minifilament's fast-eruption onset and jet-spire onset, the JBP begins brightening over the flux-cancelation neutral line. From IRIS2 inversion of the Mg II spectra, the JBP's Mg II bright plasma has electron density, temperature, and downward (red-shift) Doppler speed of 1012 cm^-3, 6000 K, and 10 kms, respectively, and the growing spire shows clockwise spin. We speculate: (i) during the slow rise of the erupting minifilament-carrying twisted flux rope, the top of the erupting flux-rope loop, by writhing, makes its field direction opposite that of encountered ambient far-reaching field; (ii) the erupting kink then can reconnect with the far-reaching field to make the spire and reconnect internally to make the JBP. We conclude that this coronal jet is normal in that magnetic flux cancelation builds a minifilament-carrying twisted flux rope and triggers the JBP-generating and jet-spire-generating eruption of the flux rope.
description: 16 pages, 9 figures, 1 table, accepted for publication in ApJ
Probing Topological signatures in an optically driven $α$-${T_3}$ Lattice
Creators: name: Tamang, Lakpa
name: Biswas, Tutul
Publisher: name: arXiv
Year: 2022
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The $α$-$T_3$ lattice, an interpolation model between the honeycomb lattice of graphene($α=0$) and the dice lattice($α=1$), undergoes a topological phase transition across $α=1/\sqrt{2}$ when exposed to a circularly polarized off-resonant light. We study Berry phase mediated bulk magnetic and anomalous thermoelectric responses in order to capture the topological signatures of a driven $α$-$T_3$ lattice. It is revealed that both the Berry curvature and the orbital magnetic moment associated with the flat band change their respective signs across $α=1/\sqrt{2}$. The off-resonant light distorts the flat band near the Dirac points when $0<α<1$ which eventually introduces two distinct well separated forbidden gaps of equal width in the quasienergy spectrum. The orbital magnetization varies linearly with the chemical potential, in the forbidden gaps. The slopes of the linear regions in the orbital magnetization are closely related to the respective Chern numbers on either side of $α=1/\sqrt{2}$. We find that the slope for $α>1/\sqrt{2}$ is approximately two times of that for $α<1/\sqrt{2}$ which essentially indicates a topological phase transition across $α=1/\sqrt{2}$. However, the anomalous Nernst coefficient vanishes when the chemical potential is tuned in the forbidden gaps. The anomalous Hall conductivity in the forbidden gap(s) approaches different quantized values on either side of $α=1/\sqrt{2}$. All these topological signatures can be observed experimentally.
description: 12 pages, 15 figures
Scale-dependent Error Growth in Navier--Stokes Simulations
Creators: name: Budanur, Nazmi Burak
name: Kantz, Holger
Publisher: name: arXiv
Year: 2022
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: We estimate the maximal Lyapunov exponent at different resolutions and Reynolds numbers in large eddy (LES) and direct numerical simulations (DNS) of sinusoidally-driven Navier--Stokes equations in three dimensions. Independent of the Reynolds number when nondimensionalized by Kolmogorov units, the LES Lyapunov exponent diverges as an inverse power of the effective grid spacing showing that the fine scale structures exhibit much faster error growth rates than the larger ones. Effectively, i.e., ignoring the cut-off of this phenomenon at the Kolmogorov scale, this behavior introduces an upper bound to the prediction horizon that can be achieved by improving the precision of initial conditions through refining of the measurement grid.
description: 13 pages, 4 figures
Low-luminosity X-ray sources and the Galactic ridge X-ray emission
Creators: name: Warwick, R. S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Using the XMM-Newton Slew Survey, we construct a hard-band selected sample of low-luminosity Galactic X-ray sources. Two source populations are represented, namely coronally-active stars and binaries (ASBs) and cataclysmic variables (CVs), with X-ray luminosities collectively spanning the range 10^(28-34) erg/s (2-10 keV). We derive the 2-10 keV X-ray luminosity function (XLF) and volume emissivity of each population. Scaled to the local stellar mass density, the latter is found to be 1.08 +/- 0.16 x 10^28 erg/s/M and 2.5 +/- 0.6 x 10^27 erg/s/M, for the ASBs and CVs respectively, which in total is a factor 2 higher than previous estimates. We employ the new XLFs to predict the X-ray source counts on the Galactic plane at l = 28.5 deg and show that the result is consistent with current observational constraints. The X-ray emission of faint, unresolved ASBs and CVs can account for a substantial fraction of the Galactic ridge X-ray emission (GRXE). We discuss a model in which roughly 80 per cent of the 6-10 keV GRXE intensity is produced in this way, with the remainder attributable to X-ray scattering in the interstellar medium and/or young Galactic source populations. Much of the hard X-ray emission attributed to the ASBs is likely to be produced during flaring episodes.
Additive manufacturing of multi-material parts – Design guidelines for manufacturing of 316L/CuCrZr in laser powder bed fusion
Creators: name: Meyer, Ina
name: Oel, Marcus
name: Ehlers, Tobias
name: Lachmayer, Roland
Publisher: name: London [u.a.] : Elsevier
Year: 2023
Subjects: subject: Design guidelines
subject: Effect-engineering
subject: Laser powder bed fusion (PBF-LB)
subject: Multi-material additive manufacturing (MMAM)
subject: Process chain
subject: Dewey Decimal Classification::000 | Allgemeines, Wissenschaft::000 | Informatik, Wissen, Systeme::000 | Informatik, Informationswissenschaft, allgemeine Werke

description: Additive manufacturing (AM) can be used to produce multi-material parts in which the material can be varied voxel-wise in all three spatial directions. This means that the paradigm of the homogeneous material can be abandoned and local effects such as heat conduction or damping can be selectively adjusted in the part. Recently, continuous development of machine technology has allowed the production of multi-metal materials in laser powder bed fusion (PBF-LB/MM). Compared to other additive manufacturing processes for multi-material production, this allows greater design freedom and detail accuracy to be realized. However, due to the novel character of multi-material manufacturing in PBF-LB, the process knowledge for successful and reproducible fabrication is currently lacking. This paper focuses on establishing design guidelines for manufacturing the material pairing of stainless steel 316L (1.4404) and copper alloy CuCrZr (CW106C). The article is accompanied by the development of a specific process chain. As a result of this work, design guidelines for multi-material parts are available for the first time, in regard to arrangement, size, overhangs, economy, powder quality and laser scanning.
Searches and tests for lepton-flavour-violating processes at CMS
Creators: name: Marchese Luigi
Publisher: name: Zenodo
Year: 2023

description: New physics can manifest itself via lepton-flavour-violating processes in LHC proton-proton collisions. This paper summaries the most recent searches for lepton-flavour-violating processes and tests of lepton flavour universality with the CMS detector, using proton-proton collisions at a centre-of-mass energy of 13~TeV.
Quantum-Classical Hybrid Systems and their Quasifree Transformations
Creators: name: Dammeier, Lars
name: Werner, Reinhard F.
Publisher: name: Wien : Verein zur Förderung des Open Access Publizierens in den Quantenwissenschaften
Year: 2023
Subjects: subject: Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik

description: We study continuous variable systems, in which quantum and classical degrees of freedom are combined and treated on the same footing. Thus all systems, including the inputs or outputs to a channel, may be quantum-classical hybrids. This allows a unified treatment of a large variety of quantum operations involving measurements or dependence on classical parameters. The basic variables are given by canonical operators with scalar commutators. Some variables may commute with all others and hence generate a classical subsystem. We systematically study the class of "quasifree" operations, which are characterized equivalently either by an intertwining condition for phase-space translations or by the requirement that, in the Heisenberg picture, Weyl operators are mapped to multiples of Weyl operators. This includes the well-known Gaussian operations, evolutions with quadratic Hamiltonians, and "linear Bosonic channels", but allows for much more general kinds of noise. For example, all states are quasifree. We sketch the analysis of quasifree preparation, measurement, repeated observation, cloning, teleportation, dense coding, the setup for the classical limit, and some aspects of irreversible dynamics, together with the precise salient tradeoffs of uncertainty, error, and disturbance. Although the spaces of observables and states are infinite dimensional for every non-trivial system that we consider, we treat the technicalities related to this in a uniform and conclusive way, providing a calculus that is both easy to use and fully rigorous.
Aluminum deposition at the osteoid-bone interface. An epiphenomenon of the osteomalacic state in vitamin D-deficient dogs.
Creators: name: Quarles, L D
name: Dennis, V W
name: Harrelson, J M
name: Gitelman, H J
name: Drezner, M K
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1985

description: Although aluminum excess is an apparent pathogenetic factor underlying osteomalacia in dialysis-treated patients with chronic renal failure, the mechanism by which aluminum impairs bone mineralization is unclear. However, the observation that aluminum is present at osteoid-bone interfaces in bone biopsies of affected patients suggests that its presence at calcification fronts disturbs the cellular and/or physiochemical processes underlying normal mineralization. Alternatively, aluminum at osteoid-bone interfaces may reflect deposition in preexistent osteomalacic bone without direct effects on the mineralization process. We investigated whether aluminum accumulates preferentially in osteomalacic bone and, if so, whether deposition of aluminum occurs at calcification fronts and specifically inhibits mineralization. Aluminum chloride (1 mg/kg) was administered intravenously three times per week for 3 wk to five normal and five vitamin D-deficient osteomalacic dogs. Before administration of aluminum the vitamin D-deficient dogs had biochemical and bone biopsy evidence of osteomalacia. Bone aluminum content in the osteomalacic dogs (15.1 +/- 2.2 micrograms/g) and the plasma aluminum concentration (10.4 +/- 2.1 micrograms/liter) were no different than those of normal dogs (10.5 +/- 3.5 micrograms/g and 11.9 +/- 1.2 microgram/liter, respectively). After the 3 wk of aluminum administration the plasma phosphorus, parathyroid hormone, and 25-hydroxyvitamin D concentrations were unchanged in normal and vitamin D-deficient dogs. Similarly, no alteration in bone histology occurred in either group. In contrast, bone aluminum content increased to a greater extent in the vitamin D-deficient dogs (390.3 +/- 24.3 micrograms/g) than in the normal dogs (73.6 +/- 10.6 micrograms/g). Moreover, aluminum localized at the osteoid-bone interfaces of the osteomalacic bone in the vitamin D-deficient dogs, covering 42.9 +/- 9.2% of the osteoid-bone surface. Further, in spite of continued aluminum chloride administration (1 mg/kg two times per week), vitamin D repletion of the vitamin D-deficient dogs for 11 wk resulted in normalization of their biochemistries. In addition, while normal dogs maintained normal bone histology during the period of continued aluminum administration, vitamin D repletion of the vitamin D-deficient dogs induced healing of their bones. Indeed, the appearance of aluminum in the cement lines of the healed bones indicated that mineralization had occurred at sites of prior aluminum deposition. These observations illustrate that aluminum deposition in osteomalacic bone may be a secondary event that does not influence bone mineralization. Thus, although aluminum may cause osteomalacia in chronic renal failure, its presence at mineralization fronts may not be the mechanism underlying this derangement.
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 4 (39)]
Creators: name: Zanboninus Zognus
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1308
Subjects: subject: Sonstige weltliche Aussteller
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Zanboninus Zognus aus der Nachbarschaft von St. Lucae [in Cremona] versichert Beluexinus, frater der Kirche St. Cataldi in Cremona, dass er bis zum Michaelisfest einen Geldbetrag auszahlen werde, den er zuvor für diesen in Verwahrung genommen hatte.
Characterization of the clotting activities of structurally different forms of activated factor IX. Enzymatic properties of normal human factor IXa alpha, factor IXa beta, and activated factor IX Chapel Hill.
Creators: name: Roberts, H R
name: Lundblad, R L
name: Briet, E
name: Griffith, M J
name: Breitkreutz, L
name: Noyes, C M
name: Trapp, H
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1985

description: Two structurally different forms of activated human Factor IX (Factor IXa alpha and IXa beta) have been previously reported to have essentially identical clotting activity in vitro. Although it has been shown that activated Factor IX Chapel Hill, an abnormal Factor IX isolated from the plasma of a patient with mild hemophilia B, and normal Factor IXa alpha are structurally very similar, the clotting activity of activated Factor IX Chapel Hill is much lower (approximately fivefold) than that of normal Factor IXa beta. In the present study we have prepared activated Factor IX by incubating human Factor IX with calcium and Russell's viper venom covalently bound to agarose. Fractionation of the activated Factor IX by high-performance liquid chromatography demonstrated the presence of both Factors IXa alpha and IXa beta. On the basis of active site concentration, determined by titration with antithrombin III, the clotting activities of activated Factor IX Chapel Hill and IXa alpha were similar, but both activities were less than 20% of the clotting activity of Factor IXa beta. Activated Factor IX activity was also measured in the absence of calcium, phospholipid, and Factor VIII, by determination of the rate of Factor X activation in the presence of polylysine. In the presence of polylysine, the rates of Factor X activation by activated Factor IX Chapel Hill, Factor IXa alpha, and Factor IXa beta were essentially identical. We conclude that the clotting activity of activated Factor IX Chapel Hill is reduced when compared with that of Factor IXa beta but essentially normal when compared with that of Factor IXa alpha.
Hopf algebra of multi-decorated rooted forests, free matching Rota-Baxter algebras and Gröbner-Shirshov bases
Creators: name: Gao, Xing
name: Guo, Li
name: Zhang, Yi
Publisher: name: arXiv
Year: 2020
Subjects: subject: Rings and Algebras (math.RA)
subject: Combinatorics (math.CO)
subject: Quantum Algebra (math.QA)
subject: FOS: Mathematics
subject: 16T30, 17B38, 05E16, 16Z10, 05C05, 16W99, 16S10, 05A05

description: Recent advances in stochastic PDEs, Hopf algebras of typed trees and integral equations have inspired the study of algebraic structures with replicating operations. To understand their algebraic and combinatorial nature, we first use rooted forests with multiple decoration sets to construct free Hopf algebras with multiple Hochschild 1-cocycle conditions. Applying the universal property of the underlying operated algebras and the method of Gröbner-Shirshov bases, we then construct free objects in the category of matching Rota-Baxter algebras which is a generalization of Rota-Baxter algebras to allow multiple Rota-Baxter operators. Finally the free matching Rota-Baxter algebras are equipped with a cocycle Hopf algebra structure.
description: 27 pages
Chemo-mechanical characterization of hydrated Calcium-Hydrosilicates with coupled Raman and nanoindentation measurements
Creators: name: Stemmermann, P.
name: Garbev, K.
name: Gasharova, B.
name: Beuchle, G.
name: Haist, M.
name: Divoux, T.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: Celitement is a new type of cement that is based on hydraulic calcium-hydrosilicate (hCHS) that possesses a potential for minimizing the ratio C/S from above 3 in OPC down to 1, which significantly reduces the amount of CO$_2$ released during processing. The reaction kinetics of hCHS differs from that of classical clinker phases due to the presence of highly reactive silicate species, which involve silanol groups instead of pure calcium silicates and aluminates and aluminoferrites. In contrast to Portland cement, no calcium hydroxide is formed during hydration, which otherwise regulates the Ca concentration. Without the buffering role of Ca(OH)$_2$ the concentration of the dissolved species c(Ca$^{2+}$) and c(SiO$_4^{4-}$) and the corresponding pH must be controlled to ensure a reproducible reaction. Pure hCHS reacts isochemically with water, resulting in a C-S-H phase with the same chemical composition as a single hydration product, with a homogeneous distribution of the main elements Ca and Si throughout the sample. Here we study via nanoindentation the mechanical properties of two different types of hardened pastes made out of Celitement (C/S=1.28), with varying amounts of hCHS and variable water to cement ratio. We couple nanoindentation grids with Raman mappings to link the nanoscale mechanical properties to individual microstructural components, yielding in-depth insight into the mechanics of the mineralogical phases constituting the hardened cement paste. We show that we can identify in hardened Celitement paste both fresh C-S-H with varying density, and C-S-H from the raw material using their specific Raman spectra, while simultaneously measuring their mechanical properties. Albeit not suitable for phase identification, EDX measurements provide valuable information about the distribution of alkalis, thus further helping to understand the reaction pattern of hCHS.
description: 32 pages, 8 figures
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 6 (79)]
Creators: name: Eugen, IV.
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1433
Subjects: subject: Papsturkunde
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Papst Eugen IV. erteilt allen Gläubigen Ablass, die an der Eucharistiefeier teilnehmen.
Fermi motion effects in electroproduction of hypernuclei
Creators: name: Bydžovský, P.
name: Denisova, D.
name: Skoupil, D.
name: Veselý, P.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: In a previous analysis of electroproduction of hypernuclei the cross sections were calculated in distorted-wave impulse approximation where the momentum of the initial proton in the nucleus was set to zero (the frozen-proton approximation). In this paper we go beyond this approximation assuming a non zero effective proton momentum due to proton Fermi motion inside of the target nucleus discussing also other kinematical effects. To this end we have derived a more general form of the two-component elementary electroproduction amplitude (Chew-Goldberger-Low-Nambu like) which allows its use in a general reference frame moving with respect to the nucleus-rest frame. The effects of Fermi motion were found to depend on kinematics and elementary amplitudes. The largest effects were observed in the contributions from the longitudinal and interference parts of the cross sections. The extension of the calculations beyond the frozen-proton approximation improved the agreement of predicted theoretical cross sections with experimental data and once we assumed the optimum on-shell approximation, we were able to remove an inconsistency which was previously present in the calculations.
description: 20 pages, 7 figures, 5 tables
A Comparison of Jet Properties Between p+p, d+Au, and Au+Au Collisions at RHIC Using Gamma-Hadron Angular Correlation Measurement
Creators: name: Chiu, Mickey G.
Publisher: name: Zenodo
Year: 2004
Subjects: jet
angular correlations
photons
centrality
jet quenching

description: Photons at high-pT are primarily from the decays of fragmentation products of a jet, and thus the photon serves as a good proxy for the underlying jet axis, hence here we look at the angular correlations between associated charged hadrons and leading high-pT photons (pT > 2.25 GeV/c). Using p+p data as a baseline, we find no strong changes in the jet widths in both d+Au and Au+Au, pointing towards a scenario where outgoing partons leave the nuclear medium and then fragment in vacuum. In d+Au, we observe a 20% decrease with centrality in the yields of moderate pT (2.0-4.0 GeV/c) jet associated particles, pointing towards a cold nuclear effect on jets in d+Au collisions.
Gallium Anomaly: Critical View from the Global Picture of $ν_{e}$ and $\barν_{e}$ Disappearance
Creators: name: Giunti, C.
name: Li, Y. F.
name: Ternes, C. A.
name: Tyagi, O.
name: Xin, Z.
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The significance of the Gallium Anomaly, from the BEST, GALLEX, and SAGE radioactive source experiments, is quantified using different theoretical calculations of the neutrino detection cross section, and its explanation due to neutrino oscillations is compared with the bounds from the analyses of reactor rate and spectral ratio data, $β$-decay data, and solar neutrino data. In the 3+1 active-sterile neutrino mixing scheme, the Gallium Anomaly is in strong tension with the individual and combined bounds of these data sets. In the combined scenario with all available data, the parameter goodness of fit is below 0.042%, corresponding to a severe tension of 4-5$σ$, or stronger. Therefore, we conclude that one should pursue other possible solutions beyond short-baseline oscillations for the Gallium Anomaly. We also present a new global fit of $ν_e$ and $\barν_e$ disappearance data, showing that there is a 2.6-3.3$σ$ preference in favor of short-baseline oscillations, which is driven by an updated analysis of reactor spectral ratio data.
description: 20 pages, 10 figures. With more discussions, version accepted for publication at Journal of High Energy Physics
Evidence for a functional role of endogenously produced somatomedinlike peptides in the regulation of DNA synthesis in cultured human fibroblasts and porcine smooth muscle cells.
Creators: name: Van Wyk, J J
name: Clemmons, D R
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1985

description: Cultured porcine aortic smooth muscle cells and human fibroblasts produce somatomedinlike peptides and secrete them into the surrounding microenvironment. This production has been linked to their ability to replicate. The objective of this study was to determine if a specific anti-somatomedin-C (Sm-C) monoclonal antibody that binds the somatomedinlike peptides could inhibit replication by porcine aortic smooth muscle cells and human fibroblasts. To determine if the antibody could inhibit the effect of endogenously produced somatomedinlike peptide, increasing concentrations of antibody were co-incubated with platelet-derived growth factor, a known stimulant of somatomedinlike peptide secretion, and Sm-C-deficient platelet-poor plasma. Addition of the antibody reduced fibroblast [3H]thymidine incorporation from 35,100 +/- 500 to 10,600 +/- 700 cpm (P less than 0.001), and in smooth muscle cells from 29,600 +/- 1,800 to 10,800 +/- 1,100 cpm (P less than 0.001). Co-incubation of exogenously added Sm-C (20 ng/ml) with maximally inhibitory dilutions of antibody increased [3H]thymidine incorporation in fibroblasts from 7,800 +/- 1,000 to 18,900 +/- 800 cpm (P less than 0.01), and in smooth muscle cells from 9,800 +/- 1,200 to 17,200 +/- 1,100 cpm (P less than 0.01). Insulin, which can substitute for Sm-C as a mitogen and does not bind to the antibody, stimulated DNA synthesis when co-incubated with the antibody, thereby excluding the possibility of nonspecific cytotoxicity. These results strengthen the hypothesis that the rate of DNA synthesis of these two cell types in vitro is directly linked to their capacity to produce somatomedinlike peptides. They further support the cellular production of somatomedinlike peptides as examples of the autocrine model of growth regulation.
RVSPY -- Radial Velocity Survey for Planets around Young Stars. Target characterization and high-cadence survey
Creators: name: Zakhozhay, O.
name: Launhardt, R.
name: Mueller, A.
name: Brems, S.
name: Eigenthaler, P.
name: Gennaro, M.
name: Hempel, A.
name: Hempel, M.
name: Henning, Th.
name: Kennedy, G.
name: Kim, S.
name: Kuerster, M.
name: Lachaume, R.
name: Manerikar, Y.
name: Patel, J.
name: Pavlov, A.
name: Reffert, S.
name: Trifonov, T.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We introduce our Radial Velocity Survey for Planets around Young stars (RVSPY), characterise our target stars, and search for substellar companions at orbital separations smaller than a few au from the host star. We use the FEROS spectrograph to obtain high signal-to-noise spectra and time series of precise radial velocities (RVs) of 111 stars most of which are surrounded by debris discs. Our target stars have spectral types between early F and late K, a median age of 400 Myr, and a median distance of 45 pc. We determine for all target stars their basic stellar parameters and present the results of the high-cadence RV survey and activity characterization. We achieve a median single-measurement RV precision of 6 m/s and derive the short-term intrinsic RV scatter of our targets (median 22 m/s), which is mostly caused by stellar activity and decays with age from >100 m/s at <20 Myr to <20 m/s at >500 Myr. We discover six previously unknown close companions with orbital periods between 10 and 100 days, three of which are low-mass stars, and three are in the brown dwarf mass regime. We detect no hot companion with an orbital period <10 days down to a median mass limit of ~1 M_Jup for stars younger than 500 Myr, which is still compatible with the established occurrence rate of such companions around main-sequence stars. We find significant RV periodicities between 1.3 and 4.5 days for 14 stars, which are, however, all caused by rotational modulation due to starspots. We also analyse the TESS photometric time series data and find significant periodicities for most of the stars. For 11 stars, the photometric periods are also clearly detected in the RV data. We also derive stellar rotation periods ranging from 1 to 10 days for 91 stars, mostly from TESS data. From the intrinsic activity-related short-term RV jitter, we derive the expected mass-detection thresholds for longer-period companions.
description: 24 pages, 14 figures, 4 tables; Accepted for publication in A&A
Necked strawberries are especially susceptible to cracking
Creators: name: Hurtado, Grecia
name: Knoche, Moritz
Publisher: name: London [u.a.] : PeerJ, Inc.
Year: 2023
Subjects: subject: Fragaria × ananassa
subject: Splitting
subject: Rupture
subject: Microcrack
subject: Macrocrack
subject: Cuticle
subject: Dewey Decimal Classification::500 | Naturwissenschaften::570 | Biowissenschaften, Biologie
subject: Dewey Decimal Classification::600 | Technik::610 | Medizin, Gesundheit

description: Fruit cracking is a commercially important disorder that reduces both quantity and quality of strawberries (Fragaria × ananassa Duch.). The objective was to identify the physiological mechanism of cracking and the factors affecting cracking. Cracking is more common in necked than in normal-shaped fruit. Most macroscopic cracks (‘macrocracks’) occur in the seedless neck. Large fruit is more cracking susceptible than medium size or small fruit. Macrocrack orientation is predominantly latitudinal in the proximal region of the neck and longitudinal in the mid and distal regions of the neck. The neck region of necked fruit has a thicker cuticle than the body of necked or normal-shaped fruit. The vascular bundles in the neck (seedless) are orientated longitudinally, while those in the body (with seeds) are both longitudinal and radial. Epidermal cells in the neck region are elongated longitudinally, with those in the proximal region of the neck being more elongated than those in the mid or distal regions of the neck. Cuticular microcracking was more severe in necked fruit than in normal-shaped fruit. The orientations of the microcracks matched those of the macrocracks, i.e., latitudinal in the proximal neck and longitudinal in the mid and distal neck regions. Following artificial incisions (blade), gaping was significantly more pronounced in necked than in normal-shaped fruit. Incubation of fruit in deionized water induced macrocracks in about 75% of fruit. Necked fruit cracked more than normal-shaped fruit. Most macrocracks were oriented latitudinally in the proximal neck and longitudinally in the distal neck regions. The results indicate cracking results from excessive growth strains which are further increased by surface water uptake.