Additional file 1 of Single-cell transcriptome profiling of an adult human cell atlas of 15 major organs
Creators: name: He, Shuai
name: Wang, Lin-He
name: Liu, Yang
name: Li, Yi-Qi
name: Chen, Hai-Tian
name: Xu, Jing-Hong
name: Peng, Wan
name: Lin, Guo-Wang
name: Wei, Pan-Pan
name: Li, Bo
name: Xia, Xiaojun
name: Wang, Dan
name: Bei, Jin-Xin
name: He, Xiaoshun
name: Guo, Zhiyong
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Figure S1. Quality information of single-cell RNA sequencing, related to Fig. 1. Figure S2. Distribution of cell cluster in each organ tissue, related to Fig. 1. Figure S2. Distribution of cell cluster in each organ tissue (continued). Figure S3. The expression of marker genes and distribution of sweat gland epithelial cells and a novel fibroblast subtype, related to Fig. 1. Figure S4. Expression of DCD, SCGB2A2, PIP, KRT19, and MUCL1 genes in skin cells derived from public datasets, related to Fig. 1. Figure S5. Expression of COCH and MMP2 in cells from multiple human samples from public datasets, related to Fig. 1. Figure S6. Gene signature of COCH+ fibroblasts in skin, related to Fig. 1. Figure S7. Expression of marker genes in cells from bladder samples derived from public datasets, related to Fig. 1. Figure S8. Representative images of immunofluorescence staining of sweat gland epithelial cells in skin samples. Figure S9. Representative images of immunofluorescence staining of COCH+ fibroblasts in the skin and heart tissues. Figure S10. Representative images of immunofluorescence staining of FibSmo cells in the bladder, rectum, and heart tissues. Figure S11. Distribution of cell clusters in different organs, related to Fig. 1. Figure S12. Comparisons of cell-type determinations by whole single-cell transcriptome dataset and manual annotation of each organ, related to Fig. 1. Figure S13. The heterogeneity and developmental trajectory analysis of T cells, related to Fig. 2. Figure S14. The heterogeneity and clonalities of T cell clones in human body, related to Fig. 2. Figure S15. The heterogeneity and clonalities of T cell clones in the human body, related to Fig. 2. Figure S16. The heterogeneity of B and plasma cells, related to Fig. 3. Figure S17. Heterogeneity and trajectory analysis of macrophages, related to Fig. 4. Figure S18. The gene expression heterogeneity of epithelial cells among inter- and intra-organ tissues, related to Fig. 5. Figure S19. Expression profiles and altered pathways in digestive and non-digestive epithelial cell clusters. Figure S20. The antigen-presenting heterogeneity and regulons of epithelial cells among inter- and intra-organ tissues, related to Fig. 5. Figure S21. The heterogeneous expression pattern of endothelial cells. Figure S22. The similarity and heterogeneity of fibroblasts and smooth muscle cells. Figure S23. Gene expression and biological functions of fibroblasts, smooth muscle and FibSmo cells. Figure S24. Overview of the ligand-receptor interactions between different cell types, related to Fig. 6. Figure S25. Overview of the ligand-receptor interactions between epithelial and myeloid cells, related to Fig. 6. Figure S26. Overview of the ligand-receptor interactions between CD8+ T and myeloid cells, related to Fig. 6. Figure S27. Overview of the ligand-receptor interactions between CD8+ T and stromal cells (fibroblast, smooth muscle cell, and FibSmo cell), related to Fig. 6. Figure S28. Pseudotime trajectory analysis and gene expression profiles of TNF_TRM and STMN1_TCM. Figure S29. Overview of the ligand-receptor interactions within epithelial cells. Figure S30. Histogram plots of the density of dissociation scores for each organ. Figure S31. Representative images of immunofluorescence staining of FOS and CD8A human tissue samples.