cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Extravasation of Contrast Medium during CT Scanning – Tracking and Reduction of Rate of Extravasation
Creators: name: Teo, Michael
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Contrast agents
subject: Vascular
subject: Veins / Vena cava
subject: CT
subject: CT-Angiography
subject: Contrast agent-intravenous
subject: Diagnostic procedure
subject: Safety
subject: Outcomes
subject: Biological effects

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Contrast enhanced CT is performed by the intravenous injection of a large volume of contrast at a high rate by an electric power injector. Extravasation of contrast media is a recognized complication of intravenous administration of contrast. While...
Physical Implementation of a Majorana Fermion Surface Code for Fault-Tolerant Quantum Computation
Creators: name: Vijay, Sagar
name: Fu, Liang
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Superconductivity (cond-mat.supr-con)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We propose a physical realization of a commuting Hamiltonian of interacting Majorana fermions realizing $Z_{2}$ topological order, using an array of Josephson-coupled topological superconductor islands. The required multi-body interaction Hamiltonian is naturally generated by a combination of charging energy induced quantum phase-slips on the superconducting islands and electron tunneling. Our setup improves on a recent proposal for implementing a Majorana fermion surface code [1], a 'hybrid' approach to fault-tolerant quantum computation that combines (1) the engineering of a stabilizer Hamiltonian with a topologically ordered ground state with (2) projective stabilizer measurements to implement error correction and a universal set of logical gates. Our hybrid strategy has advantages over the traditional surface code architecture in error suppression and single-step stabilizer measurements, and is widely applicable to implementing stabilizer codes for quantum computation.
description: 7 pages, 5 figures
MPEC 2023-T30 : 2013 FC11
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Partisanship or Ethnic Ties What Matters Most for Service Delivery
Creators: name: Kroenke, Matthias
name: Lust, Ellen
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Comparative Politics
subject: Political Science
subject: FOS: Political science
subject: Social and Behavioral Sciences
subject: Bureaucracy
subject: Conjoint Experiment
subject: Ethnicity
subject: Malawi
subject: Partisanship

description: Our project builds upon the existing literature to consider the role of both partisan and ethnic ties in the relationship between bureaucrats and citizens. A survey experiment embedded in a survey of district level bureaucrats in Malawi, complemented by survey evidence from a public opinion survey from the same districts, allows us to gauge the relative importance of ethnicity and partisanship in basic service delivery, as well as the associated explanatory mechanisms. By combining these two data sources we can overcome a common shortcoming in the extant literature – a focus on a single actor.
Chemical Abundances in the PN Wray16-423 in the Sagittarius Dwarf Spheroidal Galaxy: Constraining the Dust Composition
Creators: name: Otsuka, Masaaki
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We performed a detailed analysis of elemental abundances, dust features, and polycyclic aromatic hydrocarbons (PAHs) in the C-rich planetary nebula (PN) Wray16-423 in the Sagittarius dwarf spheroidal galaxy, based on a unique dataset taken from the Subaru/HDS, MPG/ESO FEROS, HST/WFPC2, and Spitzer/IRS. We performed the first measurements of Kr, Fe, and recombination O abundance in this PN. The extremely small [Fe/H] implies that most Fe atoms are in the solid phase, considering into account the abundance of [Ar/H]. The Spitzer/IRS spectrum displays broad 16-24 um and 30 um features, as well as PAH bands at 6-9 um and 10-14 um. The unidentified broad 16-24 um feature may not be related to iron sulfide (FeS), amorphous silicate, or PAHs. Using the spectral energy distribution model, we derived the luminosity and effective temperature of the central star, and the gas and dust masses. The observed elemental abundances and derived gas mass are in good agreement with asymptotic giant branch nucleosynthesis models for an initial mass of 1.90 Msun and a metallicity of Z=0.004. We infer that respectively about 80 %, 50 %, and 90 % of the Mg, S, and Fe atoms are in the solid phase. We also assessed the maximum possible magnesium sulfide (MgS) and iron-rich sulfide (Fe50S) masses and tested whether these species can produce the band flux of the observed 30 um feature. Depending on what fraction of the sulfur is in sulfide molecules such as CS, we conclude that MgS and Fe50S could be possible carriers of the 30 um feature in this PN.
description: 25 pages, 17 figures, 16 tables, Accepted for publication by MNRAS
A comparison of sequencing platforms and bioinformatics pipelines for compositional analysis of the gut microbiome
Creators: name: Arnold, Jason W.
name: Cadenas, Maria B
name: Butz, Natasha
name: Azcarate-Peril, Andrea
name: Allali, Imane
Publisher: name: BioMed Central
Year: 2017

description: Abstract Background Advancements in Next Generation Sequencing (NGS) technologies regarding throughput, read length and accuracy had a major impact on microbiome research by significantly improving 16S rRNA amplicon sequencing. As rapid improvements in sequencing platforms and new data analysis pipelines are introduced, it is essential to evaluate their capabilities in specific applications. The aim of this study was to assess whether the same project-specific biological conclusions regarding microbiome composition could be reached using different sequencing platforms and bioinformatics pipelines. Results Chicken cecum microbiome was analyzed by 16S rRNA amplicon sequencing using Illumina MiSeq, Ion Torrent PGM, and Roche 454 GS FLX Titanium platforms, with standard and modified protocols for library preparation. We labeled the bioinformatics pipelines included in our analysis QIIME1 and QIIME2 (de novo OTU picking [not to be confused with QIIME version 2 commonly referred to as QIIME2]), QIIME3 and QIIME4 (open reference OTU picking), UPARSE1 and UPARSE2 (each pair differs only in the use of chimera depletion methods), and DADA2 (for Illumina data only). GS FLX+ yielded the longest reads and highest quality scores, while MiSeq generated the largest number of reads after quality filtering. Declines in quality scores were observed starting at bases 150–199 for GS FLX+ and bases 90–99 for MiSeq. Scores were stable for PGM-generated data. Overall microbiome compositional profiles were comparable between platforms; however, average relative abundance of specific taxa varied depending on sequencing platform, library preparation method, and bioinformatics analysis. Specifically, QIIME with de novo OTU picking yielded the highest number of unique species and alpha diversity was reduced with UPARSE and DADA2 compared to QIIME. Conclusions The three platforms compared in this study were capable of discriminating samples by treatment, despite differences in diversity and abundance, leading to similar biological conclusions. Our results demonstrate that while there were differences in depth of coverage and phylogenetic diversity, all workflows revealed comparable treatment effects on microbial diversity. To increase reproducibility and reliability and to retain consistency between similar studies, it is important to consider the impact on data quality and relative abundance of taxa when selecting NGS platforms and analysis tools for microbiome studies.
title: Development of new educational apparatus to visualize scattered X-rays
Creators: name: Hayashi, Hiroaki
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Radiation physics
subject: Radioprotection / Radiation dose
subject: Conventional radiography
subject: Digital radiography
subject: Experimental
subject: Education
subject: Safety
subject: Physics
subject: Education and training

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: At X-ray inspections, management of scattered X-ray is important for a reduction of unneeded exposure doses. For people such as medical staff, patients and assistants, inessential exposure doses caused by scattered X-rays should be reduced ( Fig.1...
title: Investigation of the frequency dispersion of wave on the vessel wall by the magnetic resonance angiography
Creators: name: Beraia, Merabi
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Cardiovascular system
subject: Neuroradiology brain
subject: MR physics
subject: MR
subject: CT
subject: Ultrasound
subject: Computer Applications-3D
subject: Blood
subject: Arteriosclerosis

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The development of atherosclerosis is complicated with the age and the primary event seems to be repeated, injury to the artery‘s inner lining by the various mechanisms. These mechanisms include physical stresses from turbulent blood flow at the...
MPEC 2023-T31 : 2015 VH66
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
title: Multifunctional hybrid anisotropic NanoStructures for multimodal cancer imaging and controlled therapy in vivo
Creators: name: Zhang, Ruiping
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Molecular imaging
subject: Abdomen
subject: CT
subject: MR-Functional imaging
subject: Computer Applications-General
subject: Molecular, genomics and proteomics

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Novel nanomaterials are the major driving force of nanomedicine. With the rapid development of nanotechnologies, increasing researches have been focused on combining two or more diagnosis and therapeutic functions into a nanoentity. Herein, we...
Call Graph Profiling for Multi Agent Systems
Creators: name: Van Bien, Dinh Doan
name: Lillis, David
name: Collier, Rem W.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Multiagent Systems (cs.MA)
subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: The design, implementation and testing of Multi Agent Systems is typically a very complex task. While a number of specialist agent programming languages and toolkits have been created to aid in the development of such systems, the provision of associated development tools still lags behind those available for other programming paradigms. This includes tools such as debuggers and profilers to help analyse system behaviour, performance and efficiency. AgentSpotter is a profiling tool designed specifically to operate on the concepts of agent-oriented programming. This paper extends previous work on AgentSpotter by discussing its Call Graph View, which presents system performance information, with reference to the communication between the agents in the system. This is aimed at aiding developers in examining the effect that agent communication has on the processing requirements of the system.
title: Questions to be answered by MRI in the planning and evaluation of fibroid embolization
Creators: name: Maciel, Cristina
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Ischaemia / Infarction
subject: Embolisation
subject: Diagnostic procedure
subject: MR-Angiography
subject: MR
subject: Interventional vascular
subject: Genital / Reproductive system female

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: -To review the MR imaging features of the most common coexisting conditionsand alternative diagnosis to uterine fibroids. -To discuss the relevant MR imaging findings that may influence the planning of uterine artery embolization (UAE), namely the...
Journal of Neurodevelopmental Disorders reviewer acknowledgement 2012
Creators: name: Piven, Joseph
Publisher: name: BioMed Central Ltd
Year: 2013

description: Contributing reviewers The editors of Journal of Neurodevelopmental Disorders would like to thank all of our reviewers who have contributed to the journal in volume 4 (2012). High quality and timely reviews are critical to the overall quality of the journal. We are committed to providing a unique and important outlet for scholarship regarding neurodevelopmental disorders and are indebted to the outstanding reviewers who have contributed their time over the last year in helping us to reach this goal.
A new effective-one-body Hamiltonian with next-to-leading order spin-spin coupling
Creators: name: Balmelli, Simone
name: Damour, Thibault
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We present a new effective-one-body (EOB) Hamiltonian with next-to-leading order (NLO) spin-spin coupling for black hole binaries endowed with arbitrarily oriented spins. The Hamiltonian is based on the model for parallel spins and equatorial orbits developed in [Physical Review D 90, 044018 (2014)], but differs from it in several ways. In particular, the NLO spin-spin coupling is not incorporated by a redefinition of the centrifugal radius $r_c$, but by separately modifying certain sectors of the Hamiltonian, which are identified according to their dependence on the momentum vector. The gauge-fixing procedure we follow allows us to reduce the 25 different terms of the NLO spin-spin Hamiltonian in Arnowitt-Deser-Misner coordinates to only 9 EOB terms. This is an improvement with respect to the EOB model recently proposed in [Physical Review D 91, 064011 (2015)], where 12 EOB terms were involved. Another important advantage is the remarkably simple momentum structure of the spin-spin terms in the effective Hamiltonian, which is simply quadratic up to an overall square root. Moreover, a Damour-Jaranowski-Schäfer-type gauge could be established, thus allowing one to concentrate, in the case of circular and equatorial orbits, the whole spin-spin interaction in a single radial potential.
description: 18 pages, 6 figures. Submitted to Physical Review D
title: DCE MRI and DWI in the assessment of neoadjuvant chemotherapy effect in breast cancer
Creators: name: Khadartseva, Madina
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Breast
subject: MR-Diffusion/Perfusion
subject: MR
subject: Diagnostic procedure
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Neoadjuvant chemotherapy (NACT) is a widely accepted therapeutic option for patients with breast cancer. Although NACT produces good results for breast cancer patients, it has the potential to delay effective treatment in patients with...
MPEC 2023-T32 : 2020 HV4
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Novel patterns of physical activity in a large sample of preschool-aged children
Creators: name: Evenson, Kelly
Publisher: name: BioMed Central
Year: 2018

description: Abstract Background Moderate-to-vigorous physical activity (MVPA), shown to be associated with health benefits, is not well-characterized in preschool-aged children. MVPA is commonly described as a threshold amount to achieve. We examined a novel way to characterize MVPA patterns in preschool-aged children by gender and age. Methods Preschool-aged children from Nashville, TN and Minneapolis, MN wore triaxial accelerometers. Four distinct MVPA patterns were identified: isolated spurt (IS), isolated sustained activity (ISA), clustered spurt (CS), and clustered sustained activity (CSA). Multivariable linear regression models were used to test associations of gender and age with each pattern. Results One thousand one hundred thirty-one children (3.9 years old, 51% girls, 30% overweight, 11% obese, and 76% Hispanic) wore accelerometers for 12.9 (SD = 1.4) hours/day for 6.7 (SD = 0.7) days. Children spent 53% of wear time in sedentary behavior and 13% in MVPA. On average, boys and girls achieved > 90 min/day of MVPA (98.2 min, SD = 32.3). Most MVPA (80%) was obtained in spurt-like (IS and CS) MVPA; however, girls spent a higher proportion of MVPA in IS and CS, and lower proportion of time in CSA (all p < 0.001). Controlling for gender, an increase of 1-year in age corresponded to a 1.5% increase in CSA (p < 0.05). Conclusions How MVPA was obtained varied depending on the gender and age of the child. On average, boys spent more time in sustained MVPA than girls and MVPA was more sustained in older children. Utilizing these patterns could inform PA practice and policy guidelines. Trial registration NCT01316653 , date of registration: March 3, 2011; NCT01606891, date of registration: May 23, 2012.
Holographic thermalization from non relativistic branes
Creators: name: Roychowdhury, Dibakar
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this paper, based on the fundamental principles of Gauge/gravity duality and considering a \textit{global quench}, we probe the physics of thermalization for a special class of strongly coupled non relativistic QFTs by computing the entanglement entropy of the plasma. The isometry group of such QFTs is comprised of the generators of the Schrödinger algebra which could be precisely realized as an isometry group of the killing generators of an asymptotically Schrödinger $ Dp $ brane space time. In our analysis, we note that during the pre local stages of the thermal equilibrium the entanglement entropy has a faster growth in time compared to its relativistic cousin. However, it shows a linear growth during the post local stages of thermal equilibrium where the so called tsunami velocity associated with the linear growth of the entanglement entropy saturates to that of its value corresponding to the relativistic scenario. Finally, we explore the saturation region and it turns out that one must constraint certain parameters of the theory in a specific way in order to have a discontinuous transitions at the point of saturation.
description: Revised version, To appear in Physical Review D (PRD)
title: Assessment of cytoreduction after radiofrequency ablation of unresectable pancreatic adenocarcinoma: correlation between variation of Ca 19.9 and dimension of necrosis at CT.
Creators: name: D'Onofrio, Mirko
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Abdomen
subject: Pancreas
subject: CT
subject: Ablation procedures
subject: Outcomes

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Radiofrequency ablation (RFA) of pancreatic neoplasmsis restricted to locally advanced, non-resectable but nonmetastatictumors. RFA of pancreatic tumors is nowadaysan ultrasound-guided procedure performed duringlaparotomy in open surgery. To...
Measuring ex vivo drug susceptibility in Plasmodium vivax isolates from Cambodia
Creators: name: Patel, Jaymin C
name: Lin, Jessica T
name: Juliano, Jonathan
Publisher: name: BioMed Central
Year: 2017

description: Abstract Background While intensive Plasmodium falciparum multidrug resistance surveillance continues in Cambodia, relatively little is known about Plasmodium vivax drug resistance in Cambodia or elsewhere. To investigate P. vivax anti-malarial susceptibility in Cambodia, 76 fresh P. vivax isolates collected from Oddar Meanchey (northern Cambodia) in 2013–2015 were assessed for ex vivo drug susceptibility using the microscopy-based schizont maturation test (SMT) and a Plasmodium pan-species lactate dehydrogenase (pLDH) ELISA. P. vivax multidrug resistance gene 1 (pvmdr1) mutations, and copy number were analysed in a subset of isolates. Results Ex vivo testing was interpretable in 80% of isolates using the pLDH-ELISA, but only 25% with the SMT. Plasmodium vivax drug susceptibility by pLDH-ELISA was directly compared with 58 P. falciparum isolates collected from the same locations in 2013–4, tested by histidine-rich protein-2 ELISA. Median pLDH-ELISA IC50 of P. vivax isolates was significantly lower for dihydroartemisinin (3.4 vs 6.3 nM), artesunate (3.2 vs 5.7 nM), and chloroquine (22.1 vs 103.8 nM) than P. falciparum but higher for mefloquine (92 vs 66 nM). There were not significant differences for lumefantrine or doxycycline. Both P. vivax and P. falciparum had comparable median piperaquine IC50 (106.5 vs 123.8 nM), but some P. falciparum isolates were able to grow in much higher concentrations above the normal standard range used, attaining up to 100-fold greater IC50s than P. vivax. A high percentage of P. vivax isolates had pvmdr1 Y976F (78%) and F1076L (83%) mutations but none had pvmdr1 amplification. Conclusion The findings of high P. vivax IC50 to mefloquine and piperaquine, but not chloroquine, suggest significant drug pressure from drugs used to treat multidrug resistant P. falciparum in Cambodia. Plasmodium vivax isolates are frequently exposed to mefloquine and piperaquine due to mixed infections and the long elimination half-life of these drugs. Difficulty distinguishing infection due to relapsing hypnozoites versus blood-stage recrudescence complicates clinical detection of P. vivax resistance, while well-validated molecular markers of chloroquine resistance remain elusive. The pLDH assay may be a useful adjunctive tool for monitoring for emerging drug resistance, though more thorough validation is needed. Given high grade clinical chloroquine resistance observed recently in neighbouring countries, low chloroquine IC50 values seen here should not be interpreted as susceptibility in the absence of clinical data. Incorporating pLDH monitoring with therapeutic efficacy studies for individuals with P. vivax will help to further validate this field-expedient method.
Magnesium-rich Ejecta in the SNR G284.3$-$1.8 Around the High-Mass Gamma-Ray Binary 1FGL J1018.6$-$5856
Creators: name: Williams, Brian J.
name: Rangelov, Blagoy
name: Kargaltsev, Oleg
name: Pavlov, George G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present results from two {\it Chandra} observations of the 16.6 d X-ray/$γ$-ray high-mass binary 1FGL J1018.6$-$5856 located at the center of the supernova remnant G284.3$-$1.8. The binary spectra, separated by 0.25 in binary phase, are fit with an absorbed power-law model with $Γ\approx1.7-1.8$ for both observations (the flux during the second observation is a factor of 1.7 smaller). In the high-resolution ACIS-I image we found a hint of extended emission $\approx2''$--$3''$ southeast of the binary, significant at the $3σ$ level. Binary evolution codes reproduce the system's observed properties with two massive stars with an initial 18-day period, undergoing mass transfer and leaving behind a heavy $\approx2$ $\msun$ neutron star. The initial mass of the progenitor star in this scenario is 27 $\pm 4$ $\msun$. \emph{Chandra} and {\it XMM-Newton} images of the remnant show it has a relatively low X-ray surface brightness. The two brightest regions of extended X-ray emission, with luminosities $\sim10^{33}$ erg s$^{-1}$ for $d=5$ kpc, lie in the northern and western portions and show significantly different spectra. The northern patch is consistent with shocked ISM, with a low temperature and long ionization timescale. However, the western patch is dominated by ejecta, and shows significantly enhanced Mg content relative to other ejecta products. The abundance ratios inferred resemble those from the Large Magellanic Cloud remnant N49B. To our knowledge, this is only the second case of such Mg-rich ejecta found in an SNR. Nucleosynthesis models for core-collapse SNe predict Mg-rich ejecta from very massive progenitors of $>25$ $\msun$.
description: Accepted for publication in ApJ Letters
Durable response rate as an endpoint in cancer immunotherapy: insights from oncolytic virus clinical trials
Creators: name: Puzanov, Igor
name: Andtbacka, Robert H I
name: Shilkrut, Mark
name: Kaufman, Howard L
name: Zhao, Zhongyun
name: Wolf, Michael
name: Ross, Merrick
name: Collichio, Frances A
Publisher: name: BioMed Central
Year: 2017

description: Abstract Background Traditional response criteria may be insufficient to characterize full clinical benefits of anticancer immunotherapies. Consequently, endpoints such as durable response rate (DRR; a continuous response [complete or partial objective response] beginning within 12 months of treatment and lasting ≥6 months) have been employed. There has not, however, been validation that DRR correlates with other more traditional endpoints of clinical benefit such as overall survival. Methods We evaluated whether DRR was associated with clinically meaningful measures of benefit (eg, overall survival [OS], quality of life [QoL], or treatment-free interval [TFI]) in a phase 3 clinical trial of an oncolytic virus for melanoma treatment. To evaluate the association between DRR and OS and to mitigate lead time bias, landmark analyses were used. QoL was evaluated using the FACT-BRM questionnaire (comprising the FACT-BRM Physical, Social/Family, Emotional, and Functional well-being domains, the Additional Concerns, Physical and Mental treatment-specific subscales, and the Trial Outcome Index [TOI]). TFI was defined as time from the last study therapy dose to first subsequent therapy dose (including any systemic anticancer therapy for melanoma after study therapy discontinuation). Results Four hundred thirty-six patients were included in the intent-to-treat population. Achieving DR was associated with a statistically significant improvement in OS in a landmark analysis at 9 months (HR = 0.07; P = 0.0003), 12 months (HR = 0.05, P < 0.0001), and 18 months (HR = 0.11; P = 0.0002) that persisted after adjusting for disease stage and line of therapy. Achieving a DR was associated with a longer median TFI (HR = 0.33; P = 0.0007) and a higher TOI improvement rate (58.1% versus 30.0%; P = 0.025). Conclusions Achieving a DR was associated with clinical benefits such as improved OS and QoL and prolonged TFI, thus supporting the usefulness of DR as a meaningful immunotherapy clinical trial endpoint. Trial registration ClinicalTrials.gov identifier, NCT00769704 ( https://clinicaltrials.gov/ct2/show/NCT00769704 ) October 7, 2008
Random noise can help to improve synchronisation of excimer laser pulses
Creators: name: Mingesz, Robert
name: Barna, Angela
name: Gingl, Zoltan
name: Mellar, Janos
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: Recently we have reported on a compact microcontroller-based unit developed to accurately synchronise excimer laser pulses (Robert Mingesz et al, Fluct. Noise Lett. 11, 1240007 (2012), DOI: 10.1142/S021947751240007X, arXiv:1109.2632). We have shown that dithering based on the random jitter noise plus pseudorandom numbers can be used in the digital control system to radically reduce the long-term drift of the laser pulse from the trigger and to improve the accuracy of the synchronisation. In this update paper we present our new experimental results obtained by the use of the delay controller unit to tune the timing of a KrF excimer laser as an addition to our previous numerical simulation results. The hardware was interfaced to the laser using optical signal paths in order to reduce sensitivity to electromagnetic interference and the control algorithm tested by simulations were applied in the experiments. We have found that the system is able to reduce the delay uncertainty very close to the theoretical limit and performs well in real applications. The simple, compact and flexible system is universal enough to be used in various multidisciplinary applications as well.
MPEC 2023-T33 : 2022 TD
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
EOSC service model
Creators: name: Tsiakaliaris, Christos
name: Papastefanatos, George
name: Sipos, Gergely
Publisher: name: Zenodo
Year: 2021
Subjects: EOSC
service
model
service management

description: This deliverable aims to introduce the NEANIAS service management system, i.e. the set of policies, objectives, processes, procedures and tools, etc., which will support the design, development and delivery of NEANIAS services. The establishment of the NEANIAS service management system will ensure that the entire lifecycle of NEANIAS services is governed by specific rules, which in turn will ensure that the services are developed and operated in a consistent manner. Apart from the service management system, this deliverable also presents the NEANIAS service model, which adopts and extends when needed the latest EOSC service model, called EOSC Profiles (v3.0)1. The use of the EOSC model and its basic concepts as the basis for modelling the NEANIAS service providers and service descriptions covers the modelling needs of NEANIAS service providers and aims to facilitate the on-boarding of the NEANIAS services to EOSC.
ASSESSMENT OF SPATIAL DEVELOPMENT OF THE VOLGA REGIONS
Creators: name: Leontieva Lidia, S.
name: Proskurnova Ksenia Yu.
Publisher: name: Государственное управление. Электронный вестник
Year: 2023
Subjects: REGION SPACE
DEVELOPMENT
TERRITORY
VOLGA
DYNAMICS OF SPATIAL DEVELOPMENT

description: The most common approaches to assessing the development of regions include socio-economic, investment and resource analysis. Less attention is paid to assessing the spatial structure and spatial organization of territories. The study of existing approaches to the analysis of the regions’ spatial development has shown that they focus on determining the level of the spatial structure (organization) development, rather than identifying the factors influencing the development of the region’s space. This fact determined the goal to develop an approach for assessing spatial development as a process, and not as a state. This paper presents a methodology for assessing the spatial development of the Volga regions in the medium and long term with the identification of adverse factors. The study was based on a content analysis of scientific literature, a comparative analysis of various approaches devoted to the spatial development of territories, an analysis of a set of statistical indicators of Russian regions that characterize their state. The result of the analysis is the proposed approach to assessing the spatial development of the region as a process, assessing the spatial development of thirteen Volga regions and identifying the factors that negatively affected the spatial development of the selected subjects of the Russian Federation.
title: Pilot study for the detection of simulated lesions at 2D resp. 3D and CAD in FFDM
Creators: name: Schulz-Wendtland, Rüdiger
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Breast
subject: Digital radiography
subject: CAD
subject: Pathology

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Experimental study at 2D resp. 3D Full - Field digital Mammography (FFDM) and...
Dynamic Sublimation Pressure and the Catastrophic Breakup of Comet ISON
Creators: name: Steckloff, Jordan K.
name: Johnson, Brandon C.
name: Bowling, Timothy
name: Melosh, H. Jay
name: Minton, David
name: Lisse, Carey M.
name: Battams, Karl
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Previously proposed mechanisms have difficulty explaining the disruption of Comet C/2012 S1 (ISON) as it approached the Sun. We describe a novel cometary disruption mechanism whereby comet nuclei fragment and disperse through dynamic sublimation pressure, which induces differential stresses within the interior of the nucleus. When these differential stresses exceed its material strength, the nucleus breaks into fragments. We model the sublimation process thermodynamically and propose that it is responsible for the disruption of Comet ISON. We estimate the bulk unconfined crushing strength of Comet ISON's nucleus and the resulting fragments to be 0.5 Pa and 1-9 Pa respectively, assuming typical Jupiter Family Comet (JFC) albedos. However, if Comet ISON has an albedo similar to Pluto, this strength estimate drops to 0.2 Pa for the intact nucleus and 0.6-4 Pa for its fragments. Regardless of assumed albedo, these are similar to previous strength estimates of JFCs. This suggests that, if Comet ISON is representative of dynamically new comets, then low bulk strength is a primordial property of some comet nuclei, and not due to thermal processing during migration into the Jupiter Family.
description: 37 pages, 4 figures
A method for exposing rodents to resuspended particles using whole-body plethysmography
Creators: name: Wichers, Lindsay B.
Publisher: name: BioMed Central Ltd
Year: 2006

description: Abstract Background Epidemiological studies have reported increased risks of cardiopulmonary-related hospitalization and death in association with exposure to elevated levels of particulate matter (PM) across a wide range of urban areas. In response to these findings, researchers have conducted animal inhalation exposures aimed at reproducing the observed toxicologic effects. However, it is technically difficult to quantitate the actual amount of PM delivered to the lung in such studies, and dose is frequently estimated using default respiration parameters. Consequently, the interpretation of PM-induced effects in rodents exposed via whole-body inhalation is often compromised by the inability to determine deposited dose. To address this problem, we have developed an exposure system that merges the generation of dry, aerosolized particles with whole-body plethysmography (WBP), thus permitting inhalation exposures in the unrestrained rat while simultaneously obtaining data on pulmonary function. Results This system was validated using an oil combustion-derived particle (HP12) at three nominal concentrations (3, 12, and 13 mg/m3) for four consecutive exposure days (6 hr/day); a single 6-hour exposure to 13 mg/m3 of HP12 was also conducted. These results demonstrated that the system was both reliable and consistent over these exposure protocols, achieving average concentrations that were within 10% of the targeted concentration. In-line filters located on the exhaust outlets of individual WBP chambers showed relative agreement in HP12 mass for each day and were not statistically different when compared to one another (p = 0.16). Temperatures and relative humidities were also similar between chambers during PM and air exposures. Finally, detailed composition analyses of both HP12 filter and bulk samples showed that grinding and aerosolization did not change particle chemistry. Conclusion The results of this study demonstrate that it is possible to expose rodents to resuspended, dry PM via whole-body inhalation while these animals are maintained in WBP chambers. This new methodology should significantly improve the ability to assess dosimetry under minimally stressful exposure conditions.
On Multistage Learning a Hidden Hypergraph
Creators: name: D'yachkov, A. G.
name: Vorobyev, I. V.
name: Polyanskii, N. A.
name: Shchukin, V. Yu.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: Learning a hidden hypergraph is a natural generalization of the classical group testing problem that consists in detecting unknown hypergraph $H_{un}=H(V,E)$ by carrying out edge-detecting tests. In the given paper we focus our attention only on a specific family $F(t,s,\ell)$ of localized hypergraphs for which the total number of vertices $|V| = t$, the number of edges $|E|\le s$, $s\ll t$, and the cardinality of any edge $|e|\le\ell$, $\ell\ll t$. Our goal is to identify all edges of $H_{un}\in F(t,s,\ell)$ by using the minimal number of tests. We develop an adaptive algorithm that matches the information theory bound, i.e., the total number of tests of the algorithm in the worst case is at most $s\ell\log_2 t(1+o(1))$. We also discuss a probabilistic generalization of the problem.
description: 5 pages, IEEE conference
The meaning and measurement of implementation climate
Creators: name: Johnston, Matthew
name: Weiner, Bryan
name: Bergmire, Dawn M
name: Belden, Charles M
Publisher: name: BioMed Central Ltd
Year: 2011

description: Abstract Background Climate has a long history in organizational studies, but few theoretical models integrate the complex effects of climate during innovation implementation. In 1996, a theoretical model was proposed that organizations could develop a positive climate for implementation by making use of various policies and practices that promote organizational members' means, motives, and opportunities for innovation use. The model proposes that implementation climate--or the extent to which organizational members perceive that innovation use is expected, supported, and rewarded--is positively associated with implementation effectiveness. The implementation climate construct holds significant promise for advancing scientific knowledge about the organizational determinants of innovation implementation. However, the construct has not received sufficient scholarly attention, despite numerous citations in the scientific literature. In this article, we clarify the meaning of implementation climate, discuss several measurement issues, and propose guidelines for empirical study. Discussion Implementation climate differs from constructs such as organizational climate, culture, or context in two important respects: first, it has a strategic focus (implementation), and second, it is innovation-specific. Measuring implementation climate is challenging because the construct operates at the organizational level, but requires the collection of multi-dimensional perceptual data from many expected innovation users within an organization. In order to avoid problems with construct validity, assessments of within-group agreement of implementation climate measures must be carefully considered. Implementation climate implies a high degree of within-group agreement in climate perceptions. However, researchers might find it useful to distinguish implementation climate level (the average of implementation climate perceptions) from implementation climate strength (the variability of implementation climate perceptions). It is important to recognize that the implementation climate construct applies most readily to innovations that require collective, coordinated behavior change by many organizational members both for successful implementation and for realization of anticipated benefits. For innovations that do not possess these attributes, individual-level theories of behavior change could be more useful in explaining implementation effectiveness. Summary This construct has considerable value in implementation science, however, further debate and development is necessary to refine and distinguish the construct for empirical use.
title: The Apparent Diffusion Coefficient in Invasive Breast Carcinoma: Correlation with the the Biological Markers and Enhancement Patterns on Dynamic MRI
Creators: name: Matsubayashi, Roka
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Diagnostic procedure
subject: MR
subject: Breast
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: In recent years, the treatment strategy for breast carcinoma has been evolving based on analysis of various biological features of each lesion. By performing a combined modality treatment including molecular targeting drug, hormonal therapies and...
Feasibility and initial efficacy of a culturally sensitive women-centered substance use intervention in Georgia: Sex risk outcomes
Creators: name: Jones, Hendrée E
name: Murphy, Keryn
Publisher: name: BioMed Central
Year: 2015

description: Abstract Background This paper reports on the feasibility and initial efficacy of a culturally sensitive, comprehensive women-centered substance use intervention for women who inject drugs in Georgia in terms of the primary and secondary sex risk outcomes. The hypothesis under examination was that, relative to case management participants, participants in a culturally sensitive, comprehensive women-specific and -centered intervention would, on average, show significant decreases in past-30-day frequency of unprotected sex, unprotected sex at the last sexual encounter, and increases in condom use and safer sex actions. Methods The study was a two-arm randomized trial, in which 173 potentially eligible women were screened, and those 128 women determined to be eligible were assigned at random to either Reinforcement-based Treatment plus Women’s Co-Op (RBT + WC) or case management (CM). RBT + WC participants received 12 sessions of a structured intervention with the goal of reducing risky sex and substance use and improving physical and mental health. CM participants received 12 sessions of case management and informational brochures that focused on the same issues on which RBT + WC focused. Participants were assessed at baseline, post-treatment, and 3 months following treatment enrollment. Results Analyses revealed case management having significantly overall higher Safer Sex action scores than RBT + WC, and a significant decrease over time for past 30-day number of unprotected sex acts. Unprotected sex at the last encounter and Condom Use action scores were nonsignificant. Conclusions Women who inject drugs in Georgia are engaging in risky sexual practices, and are in need of an intervention that addresses these risky behaviors. Reasons for the failure to find differences between a culturally sensitive, comprehensive women-centered intervention and case management tailored to the needs of women who inject drugs in Georgia may have been the result of inadequate power to detect an effect in a sample whose drug use was not as serious as warranted by the intervention. (ClinicalTrials.gov Identifier: NCT01331460 )
A Quantum Focussing Conjecture
Creators: name: Bousso, Raphael
name: Fisher, Zachary
name: Leichenauer, Stefan
name: Wall, and Aron C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We propose a universal inequality that unifies the Bousso bound with the classical focussing theorem. Given a surface $σ$ that need not lie on a horizon, we define a finite generalized entropy $S_\text{gen}$ as the area of $σ$ in Planck units, plus the von Neumann entropy of its exterior. Given a null congruence $N$ orthogonal to $σ$, the rate of change of $S_\text{gen}$ per unit area defines a quantum expansion. We conjecture that the quantum expansion cannot increase along $N$. This extends the notion of universal focussing to cases where quantum matter may violate the null energy condition. Integrating the conjecture yields a precise version of the Strominger-Thompson Quantum Bousso Bound. Applied to locally parallel light-rays, the conjecture implies a Quantum Null Energy Condition: a lower bound on the stress tensor in terms of the second derivative of the von Neumann entropy. We sketch a proof of this novel relation in quantum field theory.
description: 45 pages, 6 figures
title: Preoperative Embolisation of Pediatric Musculoskeletal Tumours
Creators: name: Mithra, Ashok
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Interventional vascular
subject: Musculoskeletal system
subject: Oncology
subject: Catheter arteriography
subject: Embolisation
subject: Cancer

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: 1. To understandthe principles of preoperative particle embolisation 2. To learn aboutthe associated risks and complications of this...