cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Generating Evidence for COPD Clinical Guidelines Using EHRs
Creators: name: Johnson, Amber M
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Applied computing not elsewhere classified

description: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelinesare used to guide clinical practices for treating Chronic Obstructive Pulmonary Disease (COPD). GOLD focuses heavily on stable COPD patients, limiting its use fornon-stable COPD patients such as those with severe, acute exacerbations of COPD (AECOPD) that require hospitalization. Although AECOPD can be heterogeneous, it can lead to deterioration of health and early death. Electronic health records (EHRs) can be used to analyze patient data for understanding disease progression and generating guideline evidence for AECOPD patients. However, because of its structure and representation, retrieving, analyzing, and properly interpreting EHR data can be challenging, and existing tools do not provide granular analytic capabil-ities for this data.
This dissertation presents, develops, and implements a novel approach that systematically captures the effect of interventions during patient medical encounters, and hence may support evidence generation for clinical guidelines in a systematic and principled way. A conceptual framework that structures components, such as data storage, aggregation, extraction, and visualization, to support EHR data analytics for granular analysis is introduced. We develop a software framework in Python based on these components to create longitudinal representations of raw medical data extracted from the Medical Information Mart for Intensive Care (MIMIC-III) clinical database. The software framework consists of two tools: Patient Aggregated Care Events (PACE), a novel tool for constructing and visualizing entire medical histories of both individual patients and patient cohorts, and Mark SIM, a Markov Chain Monte Carlo modeling and simulation tool for predicting clinical outcomes through probabilistic analysis that captures granular temporal aspects of aggregated, clinicaldata.

We assess the efficacy of antibiotic treatment and the optimal time of initiationfor in-hospitalized AECOPD patients as an application to probabilistic modeling. We identify 697 AECOPD patients of which 26.0% were administered antibiotics. Our model simulations show a 50% decrease in mortality rate as the number of patients administered antibiotics increase, and an estimated 5.5% mortality rate when antibiotics are initially administrated after 48 hours vs 1.8% when antibiotics are initially administrated between 24 and 48 hours. Our findings suggest that there may be amortality benefit in initiation of antibiotics early in patients with acute respiratory failure in ICU patients with severe AECOPD.

Thus, we show that it is feasible to enhance representation of EHRs to aggregate patients’ entire medical histories with temporal trends and support complex clinical questions to drive clinical guidelines for COPD.
Supplemental Material, sj-pdf-6-tva-10.1177_15248380211030502 - Population-Based Estimates of Associations Between Child Maltreatment Types: A Meta-Analysis
Creators: name: Matsumoto, Maya
name: Piersiak, Hannah A.
name: Letterie, Mia C.
name: Humphreys, Kathryn L.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law

description: Supplemental Material, sj-pdf-6-tva-10.1177_15248380211030502 for Population-Based Estimates of Associations Between Child Maltreatment Types: A Meta-Analysis by Maya Matsumoto, Hannah A. Piersiak, Mia C. Letterie and Kathryn L. Humphreys in Trauma, Violence, & Abuse
PROCESSING OF NANOCOMPOSITES AND THEIR THERMAL AND RHEOLOGICAL CHARACTERIZATION
Creators: name: Faulkner, Jacob M
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Nanomaterials
Mechanical engineering not elsewhere classified
Non-Newtonian fluid flows (incl. rheology)
Additive manufacturing

description: Polymer nanocomposites are a constantly evolving material category due to the ability to engineer the mechanical, thermal, and optical properties to enhance the efficiency of a variety of systems. While a vast amount of research has focused on the physical phenomena of nanoparticles and their contribution to the improvement of such properties, the ability to implement these materials into existing commercial or newly emerging processing methods has been studied much less extensively. The primary characteristic that determines which processing technique is the most viable is the rheology or viscosity of the material. In this work, we investigate the processing methods and properties of nanocomposites for thermal interface and radiative cooling applications. The first polymer nanocomposite examined here is a two-component PDMS with graphene filler for 3D printing via a direct ink writing approach. The composite acts as a thermal interface material which can enhance cooling between a microprocessor and a heat sink by increasing the thermal conductivity of the gap. Direct ink writing requires a shear thinning ink with specific viscoelastic properties that allow for the material to yield through a nozzle as well as retain its shape without a mold following deposition. No predictive models of viscosity for nanocomposites exist; therefore, several prominent models from literature are fit with experimental data to describe the change in viscosity with the addition of filler for several different PDMS ratios. The result is an understanding of the relationship between the PDMS component ratio and graphene filler concentration with respect to viscosity, with the goal of remaining within the acceptable limits for printing via direct ink writing. The second nanocomposite system whose processability is determined is paint consisting of acrylic filled with reflective nanoparticles for radiative cooling paint applications. The paint is tested with both inkjet and screen-printing procedures with the goal of producing a thermally invisible ink. Radiative cooling paint is successfully printed for the first time with solvent modification. This work evaluates the processability of polymer nanocomposites through rheological tailoring.
Methods of Handling Missing Data in One Shot Response Based Power System Control
Creators: name: Dahal, Niraj
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Electrical engineering not elsewhere classified

description: The thesis extends the work done in [1] [2] by Rovnyak, et al. where the authors have described about transient event prediction and response based one shot control using decision trees trained and tested in a 176 bus model of WECC power system network. This thesis contains results from rigorous simulations performed to measure robustness of the existing one shot control subjected to missing PMU's data ranging from 0-10%.
We can divide the thesis into two parts in which the first part includes understanding of the work done in [2] using another set of one-shot control combinations labelled as CC2 and the second part includes measuring their robustness while assuming missing PMU's data.
Previous work from [2] involves use of decision trees for event detection based on different indices to classify a contingency as a 'Fault' or 'No fault' and another set of decision trees that decides either to actuate 'Control' or 'No control'. The actuation of control here means application of one-shot control combination to possibly bring the system to a new equilibrium point which would otherwise attain loss of synchronism.
The work done in [2] also includes assessing performance of the one shot control without event detection.
The thesis is organized as follows:Chapter 1 of the thesis highlights the effect of missing PMUs' data in a power system network and the need to address them appropriately. It also provides a general idea of transient stability and response of a transient fault in a power system.
Chapter 2 forms the foundation of the thesis as it describes the work done in [1] [2] in detail. It describes the power system model used, contingencies set, and different indices used for decision trees. It also describes about the one shot control combination (CC1) deduced by Rovnyak, et.al. of which performance is later tested in this thesis assuming different missing data scenarios. In addition to CC1, the chapter also describes another set of control combination (CC2) whose performance is also tested assuming the same missing data scenarios. This chapter also explains about the control methodology used in [2]. Finally the performance metrics of the DTs are explained at the end of the chapter. These are the same performance metrics used in [2] to measure the robustness of the one shot control. Chapter 2 is thus more a literature review of previous work plus inclusion of few simulation results obtained from CC2 using exactly the same model and same control methodology.
Chapter 3 describes different techniques of handling missing data from PMUs most of which have been used in and referred from different previous papers. Finally Chapter 4 presents the results and analysis of the simulation. The thesis is wrapped up explaining future enhancements and room for improvements.
Additional file 5 of Extracellular vesicles-coupled miRNAs from oviduct and uterus modulate signaling pathways related to lipid metabolism and bovine early embryo development
Creators: name: Mazzarella, Rosane
name: Cañón-Beltrán, Karina
name: Cajas, Yulia N.
name: Hamdi, Meriem
name: González, Encina M.
name: da Silveira, Juliano C.
name: Leal, Claudia L. V.
name: Rizos, D.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Sociology
subject: FOS: Sociology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Computational Biology

description: Additional file 5. 100 top-level gene ontology biological processes.
Additional file 1 of Long-term multicenter comparison shows equivalent efficacy of monoclonal antibodies in severe asthma therapy
Creators: name: Kayser, Moritz Z.
name: Suhling, Hendrik
name: Fuge, Jan
name: Hinze, Christopher A.
name: Drick, Nora
name: Kneidinger, Nikolaus
name: Behr, Jürgen
name: Taube, Christian
name: Welte, Tobias
name: Haasler, Ina
name: Milger, Katrin
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Hematology

description: Supplementary material 1.
DESIGN SPACE EXPLORATION OF DNNS FOR AUTONOMOUS SYSTEMS
Creators: name: Duggal, Jayan Kant
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Digital processor architectures
Other information and computing sciences not elsewhere classified

description: Developing intelligent agents that can perceive and understand the rich visual world around us has been a long-standing goal in the field of AI. Recently, a significant progress has been made by the CNNs/ DNNs to the incredible advances & in a wide range of applications such as ADAS, intelligent cameras surveillance, autonomous systems, drones, & robots. Design space exploration (DSE) of NNs and other techniques have made CNN/ DNN memory & computationally efficient. But the major design hurdles for deployment are limited resources such as computation, memory, energy efficiency, and power budget. DSE of small DNN architectures for ADAS emerged with better and efficient architectures such as baseline SqueezeNet and SqueezeNext. These architectures are exclusively known for their small model size, good model speed & model accuracy. In this thesis study, two new DNN architectures are proposed. Before diving into the proposed architectures, DSE of DNNs explores the methods to improve DNNs/ CNNs. Further, understanding the different hyperparameters tuning & experimenting with various optimizers and newly introduced methodologies. First, High Performance SqueezeNext architecture ameliorate the performance of existing DNN architectures.The intuition behind this proposed architecture is to supplant convolution layers with a more sophisticated block module & to develop a compact and efficient architecture with a competitive accuracy. Second, Shallow SqueezeNext architecture is proposed which achieves better model size results in comparison to baseline SqueezeNet and SqueezeNext is presented. It illustrates the architecture is compact, efficient and flexible in terms of model size and accuracy. The state-of-the-art SqueezeNext baseline and SqueezeNext baseline are used as the foundation to recreate and propose the both DNN architectures in this study. Due to very small model size with competitive model accuracy and decent model testing speed it is expected to perform well on the ADAS systems. The proposed architectures are trained and tested from scratch on CIFAR-10 & CIFAR-100 datasets. All the training and testing results are visualized with live loss and accuracy graphs by using livelossplot. In the last, both of the proposed DNN architectures are deployed on BlueBox2.0 by NXP.
Intersection Collision Avoidance for Autonomous Vehicles Using Petri Nets
Creators: name: Kumar, Valli Sanghami Shankar
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Electrical engineering not elsewhere classified
Autonomous vehicle systems

description: Autonomous vehicles currently dominate the automobile ﬁeld for their impact on humanity and society. Connected and Automated Vehicles (CAV’s) are vehicles that use diﬀerent communication technologies to communicate with other vehicles, infrastructure, the cloud, etc. With the information received from the sensors present, the vehicles analyze and take necessary steps for smooth, collision-free driving. This thesis talks about the cruise control system along with the intersection collision avoidance system based on Petri net models. It consists of two internal controllers for velocity and distance control, respectively, and three external ones for collision avoidance. Fault-tolerant redundant controllers are designed to keep these three controllers in check. The model is built using a PN toolbox and tested for various scenarios. The model is also validated, and its distinct properties are analyzed.
Additional file 3 of Nanoparticles systemically biodistribute to regenerating skeletal muscle in DMD
Creators: name: Hicks, Michael R.
name: Liu, Xiangsheng
name: Young, Courtney S.
name: Saleh, Kholoud
name: Ji, Ying
name: Jiang, Jinhong
name: Emami, Michael R.
name: Mokhonova, Ekaterina
name: Spencer, Melissa J.
name: Meng, Huan
name: Pyle, April D.
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Computational Biology

description: Additional file 3: Figure S3. Time course of MSNP biodistribution to skeletal muscle. Images show skeletal muscle tissue at 1, 4, 24, and 48 hrs post MSNP systemic delivery (50 mg/kg). Tissue staining reveals that MSNPs exit the microvasculature at ~4 hrs and are within the interstitial space of skeletal muscle by 24 hrs. Staining shows MSNPs (white), myofibers (laminin, red), capillaries (Cd31, green), and nuclei (DAPI, blue). Scale bars represent 20 μm.
Sigismondo Malatesta, un criminale neoplatonico. Péladan lettore mistico del Palazzo Malatestiano
Creators: name: Verna, Marisa
Publisher: name: Humanities Commons
Year: 2019
Subjects: subject: Ideology

description: This paper aims to tackle the ambiguity of Péladan’s interpretation of the Malatesta Temple of Rimini, the prestige of which is related for him to the faith in the Absolute of Art. In effect, in Példan’s novel Le Vice Suprême, Sigismondo becomes a hero for both his criminal reputation and his artistic prestige. Furthermore, in his theoretical work L’Art Idéaliste et Mystique, Péladan states that Sigismondo was devoted to the perfect religion of Beauty and was, therefore, pure. His Neoplatonic faith, as it is expressed in the artistic masterpieces of the Temple, makes him a priest of the only true Religion of Arts. This apparently linear stance veils in fact an ambivalent ideological attitude, that Péladan shares with the Decadent generation as a whole. Although conservative he was, the French writer was not aware of the consequences of some of his aesthetical statements, that inspired the far-right political movements of the early Twentieth Century’s Europe. The intrinsic ambivalence of ideological interpretation of monuments is, therefore, exemplarily represented by Péladan’s work.
Additional file 1 of Developing generic templates to shape the future for conducting integrated research platform trials
Creators: name: Gidh-Jain, Madhavi
name: Parke, Tom
name: König, Franz
name: Spiertz, Cecile
name: Mesenbrink, Peter
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Science Policy

description: Additional file 1. EU-PEARL Master Protocol Template.
AN ITERATIVE METHOD OF SENTIMENT ANALYSIS FOR RELIABLE USER EVALUATION
Creators: name: Hui, Jingyi
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Applied computing not elsewhere classified

description: Benefited from the booming social network, reading posts from other users overinternet is becoming one of commonest ways for people to intake information. Onemay also have noticed that sometimes we tend to focus on users provide well-foundedanalysis, rather than those merely who vent their emotions. This thesis aims atfinding a simple and efficient way to recognize reliable information sources amongcountless internet users by examining the sentiments from their past posts.
To achieve this goal, the research utilized a dataset of tweets about Apples stockprice retrieved from Twitter. Key features we studied include post-date, user name,number of followers of that user, and the sentiment of that tweet. Prior to makingfurther use of the dataset, tweets from users who do not have sufficient posts arefiltered out. To compare user sentiments and the derivative of Apples stock price, weuse Pearson correlation between them for to describe how well each user performs.Then we iteratively increase the weight of reliable users and lower the weight ofuntrustworthy users, the correlation between overall sentiment and the derivative ofstock price will finally converge. The final correlations for individual users are theirperformance scores. Due to the chaos of real world data, manual segmentation viadata visualization is also proposed as a denoise method to improve performance.Besides our method, other metrics can also be considered as user trust index, suchas numbers of followers of each user. Experiments are conducted to prove that ourmethod out performs others. With simple input, this method can be applied on awide range of topics including election, economy, and job market.
Additional file 3 of Developing generic templates to shape the future for conducting integrated research platform trials
Creators: name: Gidh-Jain, Madhavi
name: Parke, Tom
name: König, Franz
name: Spiertz, Cecile
name: Mesenbrink, Peter
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Science Policy

description: Additional file 3. EU-PEARL Statistical Analysis Plan template.
Staphylococcus aureus Sequences from Osteomyelitic Specimens of a Pathological Bone Collection from Pre-Antibiotic Times
Creators: name: Flux, Anna Lena
name: Mazanec, Janine
name: Strommenger, Birgit
name: Hummel, Susanne
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2017
Subjects: subject: infectious diseases
subject: PCR
subject: Staphylococcus aureus
subject: osteomyelitis
subject: ancient DNA
subject: pathological bone collection
subject: skeletal material
subject: historical pathogens
subject: pre-antibiotic era
subject: 610 Medizin

description: Staphylococcus aureus is a major pathogen causing osteomyelitis, amongst other diseases, and its methicillin-resistant form (MRSA) in particular poses a huge threat to public health. To increase our knowledge of the origin and evolution of S. aureus, genetic studies of historical microorganisms may be beneficial. Thus, the aim of this study was to investigate whether osteomyelitic skeletal material (autopsy specimens collected from the mid 19th century until the 1920s) is suitable for detecting historical S. aureus DNA sequences. We established a PCR-based analysis system targeting two specific genes of S. aureus (nuc and fib). We successfully amplified the historical S. aureus nuc and fib sequences for six and seven pre-antibiotic, osteomyelitic bone specimens, respectively. These results encourage further investigations of historical S. aureus genomes that may increase our understanding of pathogen evolution in relation to anthropogenically introduced antibiotics.
Additional file 4 of Developing generic templates to shape the future for conducting integrated research platform trials
Creators: name: Gidh-Jain, Madhavi
name: Parke, Tom
name: König, Franz
name: Spiertz, Cecile
name: Mesenbrink, Peter
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Science Policy

description: Additional file 4. EU-PEARL Guidance to CTR Cover letter.
PHOTOGRAMMETRY FOR 3D RECONSTRUCTION IN SOLIDWORKS AND ITS APPLICATIONS IN INDUSTRY
Creators: name: Potabatti, Nikhil Satyanarrayan
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Mechanical engineering not elsewhere classified

description: Photogrammetry and laser scanning are two primary methods used for object reconstruction / reverse engineering. But Laser scanners have much higher initial investment compared to photogrammetry method.Currently, in the industry, researchers have been using 3 different softwares for reverse engineering purposes from photogrammetry/laser scanning.
This thesis is to showcase research work with following points:1. Comparison between laser scanner and photogrammetry tools.2. Application of photogrammetry in the industry.3. Evaluation of photogrammetry tools based on quality of mesh results and comparison with baseline standard of laser-scanner results.4. Proposed integrated methodology with photogrammetry tool for reverse engineering within single environment. 5. Validation of this integrated methodology with case studies.6. Parametric study of tool for accuracy and comparison with actual standard models.
The Montreal Cognitive Assessment (MoCA) in a population-based sample of Turkish migrants living in Germany
Creators: name: Krist, Lilian
name: Keller, Theresa
name: Sebald, Lisa
name: Yesil-Jürgens, Rahsan
name: Ellert, Ute
name: Reich, Andreas
name: Becher, Heiko
name: Heuschmann, Peter U.
name: Willich, Stefan N.
name: Keil, Thomas
name: Liman, Thomas G.
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2017
Subjects: subject: Mild cognitive impairment
subject: Turkish migrants
subject: population-based
subject: Montreal Cognitive Assessment (MoCA)
subject: 610 Medizin

description: Objectives: Data on cognitive testing in migrants in Germany are scarce. We aimed to evaluate the Montreal Cognitive Assessment (MoCA) in Turkish migrants in Berlin and its association with demographics and health-related variables. Method: For this cross-sectional study, a random sample of persons with Turkish names was drawn from the registration-office. Cognitive function was assessed using the MoCA; 0 = worst, 30 = best total score. Multivariable linear regression models were calculated to determine associated factors with the total MoCA-score. Results: In our analyses we included 282 participants (50% female), mean age 42.3 ± 11.9 years (mean ± standard deviation (SD)). The mean ± SD MoCA score was 23.3 ± 4.3. In the multivariable analysis, higher education (ß = 2.68; p < 0.001), and chosing the German version of the MoCA (ß = –1.13; p = 0.026), were associated with higher MoCA-scores, whereas higher age (ß = –0.08; p = 0.002) was associated with lower MoCA scores. Conclusion: In our study, a higher educational level, lower age, and German as the preferred test language (as compared to Turkish) were positively associated with the cognitive performance of Berliners with Turkish roots. To examine neurocognitive health of migrants, longitudinal population-based and clinical cohort studies that specifically compare migrants and their descendants with the original population of their home countries are required.
Supplemental material for this article is available online.
Creators: name: Martínez-Catena, Ana
name: Redondo, Santiago
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law

description: Supplemental Material for Treatment and Therapeutic Change of Individuals Imprisoned for Child Abuse in the Barcelona Study on Sex Offenders by Ana Martínez-Catena and Santiago Redondo, in Journal of Interpersonal Violence
VIM-1 carbapenemase-producing Escherichia coli isolated from retail seafood, Germany 2016
Creators: name: Roschanski, Nicole
name: Guenther, Sebastian
name: Vu, Thi Thu Tra
name: Fischer, Jennie
name: Semmler, Torsten
name: Huehn, Stephan
name: Alter, Thomas
name: Roesler, Uwe
Publisher: name: Robert Koch-Institut
Year: 2017
Subjects: subject: 610 Medizin

description: Carbapenems belong to the group of last resort antibiotics in human medicine. Therefore, the emergence of growing numbers of carbapenemase-producing bacteria in food-producing animals or the environment is worrying and an important concern for the public health sector. In the present study, a set of 45 Enterobacteriaceae isolated from German retail seafood (clams and shrimps), sampled in 2016, were investigated by real-time PCR for the presence of carbapenemase-producing bacteria. One Escherichia coli (ST10), isolated from a Venus clam (Ruditapes philippinarum) harvested in the Mediterranean Sea (Italy), contained the carbapenemase gene blaVIM-1 as part of the variable region of a class I integron. Wholegenome sequencing indicated that the integron was embedded in a Tn3-like transposon that also contained the fluoroquinolone resistance gene qnrS1. Additional resistance genes such as the extended-spectrum betalactamase blaSHV-12 and the AmpC gene blaACC-1 were also present in this isolate. Except blaACC-1, all resistance genes were located on an IncY plasmid. These results confirm previous observations that carbapenemase- producing bacteria have reached the food chain and are of increasing concern for public health.
Dietary Acid Load and Potassium Intake Associate with Blood Pressure and Hypertension Prevalence in a Representative Sample of the German Adult Population
Creators: name: Krupp, Danika
name: Esche, Jonas
name: Mensink, Gert
name: Klenow, Stefanie
name: Thamm, Michael
name: Remer, Thomas
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2018
Subjects: subject: DEGS1
subject: hypertension
subject: blood pressure
subject: dietary acid load
subject: PRAL
subject: potassium intake
subject: 610 Medizin

description: Diets rich in fruits and vegetables, like the Dietary Approaches to Stop Hypertension (DASH)-diet, are usually characterized by high potassium intake and reduced dietary acid load, and have been shown to reduce blood pressure (BP). However, the relevance of potential renal acid load (PRAL) for BP has not been compared with the relevance to BP of urinary biomarker (K-urine)- and dietary food frequency questionnaire (K-FFQ)-based estimates of potassium intake in a general adult population sample. For 6788 participants (aged 18–79 years) of the representative German Health-Interview and Examination Survey for Adults (DEGS1), associations of PRAL, K-urine, and K-FFQ with BP and hypertension prevalence were cross-sectionally examined in multivariable linear and logistic regression models. PRAL was significantly associated with higher systolic BP (p = 0.0002) and higher hypertension prevalence (Odds ratio [OR] high vs. low PRAL = 1.45, p = 0.0004) in models adjusted for age, sex, body mass index (BMI), estimated sodium intake, kidney function, relevant medication, and further important covariates. Higher estimates of K-FFQ and K-urine were related to lower systolic BP (p = 0.04 and p < 0.0001) and lower hypertension prevalence (OR = 0.82, p = 0.04 and OR = 0.77, p = 0.02) as well as a lower diastolic BP (p = 0.03 and p = 0.0003). Our results show, for the first time in a comparative analysis of a large representative population sample, significant relationships of BP and hypertension prevalence with questionnaire- and biomarker-based estimates of potassium intake and with an estimate of dietary acid load.
APPLYING DIFFERENT WIDE-AREA RESPONSE-BASED CONTROLS TO DIFFERENT CONTINGENCIES IN POWER SYSTEMS
Creators: name: Iranmanesh, Shahrzad
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Electrical engineering not elsewhere classified

description: The electrical disturbances in the power system have threaten the stability of the system. In the first step, it is necessary to detect these electrical disturbances or events. In the next step, a proper control should apply to the system to decrease the consequences of the disturbances. One-shot control is one of the effective methods for stabilizing the events. In this method, a proper amount of loads are increased or decreased to the electrical system. Determining the amounts of loads, and the location for shedding is crucial. Moreover, some control combinations are more effective for some events and less effective for some others. Therefore, this project is completed in two different sections. First, finding the effective control combinations, second, finding an algorithm for applying different control combinations to different contingencies in real time. To find the effective control combinations, sensitivity analysis is employed to locate the most effective loads in the system. Then in order to find the control combination commands, gradient descent and PSO algorithm are used in this project. In the next step, a pattern recognition method is used to apply the appropriate control combination for every event. The decision tree is selected as the pattern recognition method. The three most effective control combinations found by sensitivity analysis and PSO method are used in the remainder of this study. A decision tree is trained for each of the three control combinations, and their outputs are combined into an algorithm for selecting the best control in real time. Finally, the algorithm is evaluated using a test set of contingencies. The final results reveal a 30\% improvement in comparison to the previous studies.
Clinically Relevant ESBL-Producing K. pneumoniae ST307 and E. coli ST38 in an Urban West African Rat Population
Creators: name: Schaufler, Katharina
name: Nowak, Kathrin
name: Düx, Ariane
name: Semmler, Torsten
name: Villa, Laura
name: Kourouma, Laye
name: Bangoura, Karim
name: Wieler, Lothar H.
name: Leendertz, Fabian H.
name: Guenther, Sebastian
Publisher: name: Robert Koch-Institut
Year: 2018
Subjects: subject: 610 Medizin

description: High-risk ESBL-producing Enterobacteriaceae (ESBL-E) have been described in wild birds and rodents worldwide. Rats are of special interest not only due to their indicator role for environmental pollution with multi-resistant bacteria but also as possible infection source. Data on the presence of high-risk ESBL-E in urban wildlife from Africa remain scarce, however. Twenty-nine animals from three different rat (Rattus) species were captured in the city of Conakry (Guinea, West Africa) in 2015. Rectal swabs were analyzed for ESBL-E using selective media. Species typing and phenotypic antimicrobial resistance analysis to broad-spectrum beta-lactams and other classes of antimicrobials was performed for Enterobacteriaceae-like isolates using the VITEK®2 system (BioMérieux, Germany). Confirmed ESBL-producing E. coli and K. pneumoniae were whole-genome sequenced and resistance genes, phylogenetic background and genes related to bacterial fitness and virulence were analyzed. In total, six of twenty-nine rats (20%) carried ESBL-E (K. pneumoniae and E. coli). All ESBL-producers were multi-drug resistant with blaCTX−M−15 as the dominating ESBL-type. Interestingly, ESBL-associated clonal lineages E. coli ST38 and K. pneumoniae ST307 were found. The ESBL-plasmid in K. pneumoniae ST307 revealed high sequence similarities to pKPN3-307_TypeC, a >200 kbp IncFII plasmid originating from a human clinical ST307 isolate. This was in contrast to the core genome: the rat isolate was distantly related to the human clinical ST307 isolate (27 SNPs/Mbp). In addition, we identified π-fimbrial, capsule 2, and glycogen synthesis clusters in the rodent ST307 isolate, whose involvement in the adaptation to survival outside the host and in human urinary tracts has been suggested. Our results demonstrate the presence of clinically relevant, ESBL-producing K. pneumoniae ST307 and E. coli ST38 clonal lineages in an urban West African rat population. The human community is likely the initial source of ESBL-E however, rats might function as infection source and transmission hub, accelerated by frequent interactions at a human-wildlife interface.
EMERGING TOPICS IN SUPPLY CHAIN MANAGEMENT: PRODUCT SUBSTITUTION, DEMAND AMBIGUITY, AND ENVIRONMENTAL AND SOCIAL RESPONSIBILITY
Creators: name: Li, Chengzhang
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Logistics
Supply chains

description: This study examines several emerging topics in supply chain management including the dynamic product substitution, the joint optimization of price and order quantity with demand ambiguity, and the implementation of the environmental and social responsibility (ESR) programs.
The Health Care System in Zimbabwe
Creators: name: Nhapi, Tatenda
Publisher: name: Universität Bremen
Year: 2024
Subjects: subject: Zimbabwe
subject: health
subject: health care
subject: health care system
subject: 300

description: This country report provides a description of the emergence of a health care system under public responsibility in Zimbabwe. The inception of the health care system refers to the first legislation stipulating entitlements to medical care. The report also includes a brief description of major health care reforms, and the current organization of the health care system in Zimbabwe. This report is part of the CRC 1342 Social Policy Country Briefs Series.
Additional file 2 of Developing generic templates to shape the future for conducting integrated research platform trials
Creators: name: Gidh-Jain, Madhavi
name: Parke, Tom
name: König, Franz
name: Spiertz, Cecile
name: Mesenbrink, Peter
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Science Policy

description: Additional file 2. EU-PEARL Intervention Specific Appendix template.
„Theoretisch dachte ich, es funktioniert, und in der Praxis finde ich, funktioniert es nicht“: die Rolle der Lehrperson in Designexperimenten
Creators: name: Grünewald, Andreas
Publisher: name: Springer VS
Year: 2019
Subjects: subject: Designexperiment
subject: Französischunterricht
subject: Rolle Lehrkraft
subject: Umgang mit Innovation
subject: 400

description: Der Beitrag beruht auf zwei leitfadengestützten Interviews mit Lehrkräften und einem Interview mit einer Schulleiterin. Die Lehrpersonen waren an der Durchführung des Projekts zur Förderung des literarisch-ästhetischen Lernens im Französischunterricht beteiligt. Die Interviews werden entlang der Leitfragen des Gesamtprojekts (Umgang mit der Intervention durch das Design und Veränderung im Fachunterricht durch Oberschulreform) ausgewertet. Die Interviews geben einen Einblick zur Weiterentwicklung des erprobten Designs einerseits und in die Attribuierungen zu Wandel und Innnovationen andererseits. Dabei zeigen sich unterschiedliche Einstellungen und Zuschreibungen sowie Unsicherheiten im Umgang mit dem Design und unterschiedliche Deutungen der Rolle des Designs für den fachlichen Wandel. Abschließend werden die Befunde auf ein Modell zum professionellen Lehrerhandeln bezogen, das im Wesentlichen auf Devon Woods’ BAK-Modell (1996) zurückgeht.
Comparative phosphoproteomic analysis reveals signaling networks regulating monopolar and bipolar cytokinesis
Creators: name: Karayel, Özge
name: Şanal, Erdem
name: Giese, Sven H.
name: Kagıalı, Zeynep Cansu Üretmen
name: Polat, Ayşe Nur
name: Hu, Chi-Kuo
name: Renard, Bernhard Y.
name: Tuncbag, Nurcan
name: Özlü, Nurhan
Publisher: name: Robert Koch-Institut
Year: 2018
Subjects: subject: 610 Medizin

description: The successful completion of cytokinesis requires the coordinated activities of diverse cellular components including membranes, cytoskeletal elements and chromosomes that together form partly redundant pathways, depending on the cell type. The biochemical analysis of this process is challenging due to its dynamic and rapid nature. Here, we systematically compared monopolar and bipolar cytokinesis and demonstrated that monopolar cytokinesis is a good surrogate for cytokinesis and it is a well-suited system for global biochemical analysis in mammalian cells. Based on this, we established a phosphoproteomic signature of cytokinesis. More than 10,000 phosphorylation sites were systematically monitored; around 800 of those were up-regulated during cytokinesis. Reconstructing the kinase-substrate interaction network revealed 31 potentially active kinases during cytokinesis. The kinase-substrate network connects proteins between cytoskeleton, membrane and cell cycle machinery. We also found consensus motifs of phosphorylation sites that can serve as biochemical markers specific to cytokinesis. Beyond the kinase-substrate network, our reconstructed signaling network suggests that combination of sumoylation and phosphorylation may regulate monopolar cytokinesis specific signaling pathways. Our analysis provides a systematic approach to the comparison of different cytokinesis types to reveal alternative ways and a global overview, in which conserved genes work together and organize chromatin and cytoplasm during cytokinesis.
Hepatitis C virus: Morphogenesis, infection and therapy
Creators: name: Morozov, Vladimir Alexei
name: Lagaye, Sylvie
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2018
Subjects: subject: Transmission
subject: Pathogenesis
subject: Treatment
subject: Hepatitis C virus
subject: Molecular biology
subject: In vitro and ex vivo models of hepatitis C virus infection
subject: 610 Medizin

description: Hepatitis C virus (HCV) is a major cause of liver diseases including liver cirrhosis and hepatocellular carcinoma. Approximately 3% of the world population is infected with HCV. Thus, HCV infection is considered a public healthy challenge. It is worth mentioning, that the HCV prevalence is dependent on the countries with infection rates around 20% in high endemic countries. The review summarizes recent data on HCV molecular biology, the physiopathology of infection (immune-mediated liver damage, liver fibrosis and lipid metabolism), virus diagnostic and treatment. In addition, currently available in vitro, ex vivo and animal models to study the virus life cycle, virus pathogenesis and therapy are described. Understanding of both host and viral factors may in the future lead to creation of new approaches in generation of an efficient therapeutic vaccine.
Device-Circuit Co-Design Employing Phase Transition Materials for Low Power Electronics
Creators: name: Aziz, Ahmedullah
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Circuits and systems
Microelectronics
Nanoelectronics
Nanomaterials

description: Phase transition materials (PTM) have garnered immense interest in concurrent post-CMOS electronics, due to their unique properties such as - electrically driven abrupt resistance switching, hysteresis, and high selectivity. The phase transitions can be attributed to diverse material-specific phenomena, including- correlated electrons, filamentary ion diffusion, and dimerization. In this research, we explore the application space for these materials through extensive device-circuit co-design and propose new ideas harnessing their unique electrical properties. The abrupt transitions and high selectivity of PTMs enable steep (< 60 mV/decade) switching characteristics in Hyper-FET, a promising post-CMOS transistor. We explore device-circuit co-design methodology for Hyper-FET and identify the criterion for material down-selection. We evaluate the achievable voltage swing, energy-delay trade-off, and noise response for this novel device. In addition to the application in low power logic device, PTMs can actively facilitate non-volatile memory design. We propose a PTM augmented Spin Transfer Torque (STT) MRAM that utilizes selective phase transitions to boost the sense margin and stability of stored data, simultaneously. We show that such selective transitions can also be used to improve other MRAM designs with separate read/write paths, avoiding the possibility of read-write conflicts. Further, we analyze the application of PTMs as selectors in cross-point memories. We establish a general simulation framework for cross-point memory array with PTM based selector. We explore the biasing constraints, develop detailed design methodology, and deduce figures of merit for PTM selectors. We also develop a computationally efficient compact model to estimate the leakage through the sneak paths in a cross-point array. Subsequently, we present a new sense amplifier design utilizing PTM, which offers built-in tunable reference with low power and area demand. Finally, we show that the hysteretic characteristics of unipolar PTMs can be utilized to achieve highly efficient rectification. We validate the idea by demonstrating significant design improvements in a Cockcroft-Walton Multiplier, implemented with TS based rectifiers. We emphasize the need to explore other PTMs with high endurance, thermal stability, and faster switching to enable many more innovative applications in the future.
Instantaneous Antimicrobial Susceptibility Testing Using Piezoelectric Sensors
Creators: name: Elquist, Aline M
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Medical devices
Biomedical engineering not elsewhere classified

description: Rapid determination of drugs effective against bacterial strains is critically important to stopping further spread of an infection and reducing antibiotic resistance. Antimicrobial susceptibility testing (AST) is done to determine what type of antibiotic and what concentration will be effective in treating an infection. Current, growth-dependent, AST methods are reliant on the growth rate of the bacteria and can take several days to several weeks to get results. A piezoelectric plate sensor can be used to measure an instant change in the minute physiological stresses of the bacteria cells when they are exposed to an effective concentration of antibiotic. This work aims to investigate the feasibility of piezoelectric plate sensors used for instantaneous AST (iAST) results and develop a technological framework for scaling this technology to a clinical lab setting. Four Clinical and Laboratory Standards Institute (CLSI) quality control strains of bacteria were tested with a wide range of antibiotics from various drug classes using the piezoelectric sensor. Results were obtained within 30 minutes and compared to standard of care AST methods used in clinical labs, and CLSI prescribed ranges for each strain of bacteria. This thesis will also discuss a framework for developing more scalable sensors, and challenges associated with the different sensor designs.
Supplemental Material, sj-pdf-1-ppq-10.1177_13540688211032367 - What are we voting for? Opposition alliance joint campaigns in electoral autocracies
Creators: name: Ong, Elvin
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160607 International Relations
subject: FOS: Political science

description: Supplemental Material, sj-pdf-1-ppq-10.1177_13540688211032367 for What are we voting for? Opposition alliance joint campaigns in electoral autocracies by Elvin Ong in Party Politics
Additional file 1 of Stressors, emotions, and social support systems among respiratory nurses during the Omicron outbreak in China: a qualitative study
Creators: name: Yu, Wenzhen
name: Zhang, Ying
name: Xianyu, Yunyan
name: Cheng, Dan
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 1
Técnicas de análisis de ADN para reconocimiento post-mortem, una alternativa biotecnológica
Creators: name: Nicanor Gaspar, Abigail
Publisher: name: Benemérita Universidad Autónoma de Puebla
Year: 2024
Subjects: PCR
perfil
X-STR
marcadores
forense

description: Resumen

Existen múltiples investigaciones donde puede ser necesaria la aplicación de las ciencias forenses. Estas incluyen la participación de varias ramas científicas como son: la física, la química, la medicina, la biología, biotecnología, etc. Pero su principal objetivo es el reconocimiento, la identificación y la evaluación de pruebas físicas para procedimientos legales. La reacción en cadena de polimerasa (PCR) permite amplificar más de un millón de veces un ADN obtenido a partir de una región seleccionada del genoma, analizando un determinado número de regiones polimórficas, la probabilidad de que dos individuos sean genéticamente iguales es prácticamente nula. Por ello, puede utilizarse como prueba para ayudar a condenar a un sospechoso de un delito, o para absolver a una persona inocente. Se hace uso de muestras tomadas en el lugar del delito o de los sospechosos, que normalmente son sangre, pelo o fluidos corporales, así se obtiene un perfil de ADN que puede compararse con otros perfiles si es que se cuenta con una base de datos. De este modo, se pueden descubrir conexiones entre distintos lugares del delito, entre personas y lugares del delito. Además, el ADN puede utilizarse para identificar a víctimas de catástrofes, localizar a personas desaparecidas e incluso precisar la procedencia de mercancías objeto de tráfico como marfil o madera. Las repeticiones cortas en tándem del cromosoma X(X-STR) son utilizadas en la identificación forense y en pruebas de parentesco biológico. Actualmente existen varios estudios en los X-STR, sin embargo, el panel incluye varios marcadores del mismo grupo de ligamiento. Al incluir marcadores de diferente grupo de ligamiento la prueba es más eficiente. En el presente trabajo se presenta un estudio de cinco loci X-STR para su aplicación en estudios genéticos forenses en población mestiza del occidente de México. Se tipificaron cinco loci X-STR en 379 muestras de individuos del occidente de México mediante PCR, geles de poliacrilamida al 7% y tinción con plata. Se estimaron las frecuencias alélicas y haploticas, así como los parámetros forenses. En los resultados los datos combinados mostraron un poder de discriminación de 0.999389 y 0.99995 en hombres y mujeres respectivamente. La combinación de la probabilidad media de exclusión fue 0.9998797 para casos de tríos y 0.990701 para dúos. En el sistema Decaplex, sistema usado en diversos reportes, se pueden consultar valores de discriminación en mujeres de 99.9999% y en hombres de 99.9998%, los cuales son resultados muy cercanos al obtenido en el estudio, demostrando que con utilizar solo cinco loci se pueden obtener datos altamente informativos para uso en pruebas forenses.  Esta ponencia se basó en las referencias [1-9].