cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Multiple Ecological Drivers Determining Vegetation Attributes across Scales in a Mountainous Dry Valley, Southwest China
Creators: name: Yang, Jie
name: El-Kassaby, Yousry A.
name: Guan, Wenbin
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2020

description: Identifying the ecological processes determining spatial variation in community composition and structure is a central issue in arid areas, especially in the face of climate change. This study aims to estimate how environmental and spatial processes jointly determine vegetation attributes across scales in the Min dry valley, one of the dry valleys in Hengduan Mountainous region suffering severe ecological degradation. A total of 48 plots along slope transects were investigated at three sites along the dry valley, with vegetation and environmental information gathered. Distance-based Moran’s eigenvector maps (dbMEM) was used to extract local spatial variables, while geographic coordinates were used as regional spatial variables. We used redundancy analysis (RDA) and variation partitioning to detect the relative importance of environmental and spatial processes in influencing community composition and vegetation structure (including biomass, coverage, height, density, α and β diversity), and to identify the most determinant environmental variables at different spatial scales. Results showed that both environmental and spatial processes accounted for significant and comparable variations in both vegetation composition and structure. Local spatial variables provided significant and comparable contribution as regional spatial variables to vegetation composition, while provided more contribution than regional spatial variables to vegetation structure. Topography had an overriding effect relative to soil on both vegetation composition and structure. Multi-scale analyses showed elevation was the most important variable (associated with soil moisture and nutrient) at the regional scale; while microtopography, especially slope aspect and shape, dominated at the local scale. We also demonstrated how vegetation composition and structure varied along environmental gradients. The study revealed the overriding role of topography in determining vegetation attributes in this mountainous dry valley, highlighting the advantage of multi-scale spatial analysis for better understanding spatial variation in vegetation pattern and with their important implications for biodiversity conservation and ecological management in the arid mountain areas.
La réforme pénale de 1984 au Brésil : pourquoi est-il si difficile de réduire le recours à l'incarcération?
Creators: name: Mendonça Raupp, Mariana
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: réforme pénale
théories de la peine
punition
prison
réhabilitation
rationalité pénale moderne

description: Cette thèse s’interroge sur les possibilités et les difficultés de reconstruire le droit criminel moderne et a comme point d’observation empirique les travaux d’une Commission brésilienne de juristes qui élabora une proposition législative restée connue comme étant « la réforme pénale de 1984 ». Cette Commission, active entre 1980 et 1983, avait comme but d’étudier et de proposer des changements à la législation criminelle brésilienne en visant surtout la réduction du recours à la prison et la création de peines non carcérales. La thèse montre comment cette réforme, conçue par une Commission de juristes libéraux et progressistes, ne réussit pas à transformer une critique de la prison en changements législatifs innovateurs. À partir de la problématique de la (non) évolution du droit criminel moderne, formulée par la théorie de la rationalité pénale moderne d’Alvaro Pires, cette étude privilégie l’observation des propositions législatives de ladite réforme concernant la détermination de la peine et les normes de sanctions ainsi que les discours sous-jacents. Ainsi, la thèse identifie les obstacles cognitifs qui empêchèrent la réforme d’accomplir ses deux objectifs principaux. Le matériel empirique est composé majoritairement de documents et de quelques entretiens. Les documents comprennent les textes de réflexion sur les propositions de réforme élaborées par la Commission et les textes de propositions législatives. Nous avons également interviewé les juristes membres de la Commission de la réforme de 1984, lorsque c’était encore possible, de même que certains juristes qui suivaient à l’époque les travaux de la Commission et qui nous ont servi de personnes-ressources pour la composition de notre matériel empirique. L’analyse de ce matériel fait ressortir que le fort attachement de la commission aux théories de la peine du noyau dur de la rationalité pénale moderne (la rétribution, la dissuasion et la dénonciation) ainsi que la dévalorisation de la théorie de la réhabilitation dans la pratique de détermination de la peine réduisirent la portée des propositions quant aux objectifs de la Commission.
The Quest for Control in Canadian Defence Policy: The Evolution of Defence Management and Organization, 1963–1972
Creators: name: Thompson, Michael
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Defence
Policy
Management
Military
Armed Forces
Unification
Paul Hellyer

description: This study examines the evolution of Canadian defence organization and administration from the integration and unification of the Canadian Forces, starting with the arrival of Paul Hellyer as Minister of National Defence in 1963, to the full integration of military and civilian staffs at National Defence Headquarters in 1972. It seeks to understand the underlying defence management philosophy by explaining the evolving decision-making process and how and why certain management techniques and organizational concepts came to be embodied in the policy process. The goal of this work is to gain insight into not only the management of defence but its relationship to, and place within, general organization and management theory. The idea of rationalizing the business of defence lies at the heart of the history of the reorganizations in the 1960s and early 1970s. Management and organization were arranged to allow defence decision-making to become a more rational process, characterized by new degrees of control, in order to aid the overall effectiveness of the policy-making process. Overall, there existed a progression of administrative and management rationalization that had been occurring not only in the post-Second World War era, but since the turn of the century, both within and without the public sphere. While there was much to be critical about unification and the general defence policy vision of Hellyer, the evolution and development of modern management techniques in defence during the 1960s can largely be situated within an ongoing history of bureaucratization and management evolution of large scale organizations in general and military organizations in particular.
Long-range Communication Framework for Autonomous UAVs
Creators: name: Elchin, Mammadov
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Multiple UAV communication
DigiMesh
Long-range mesh network

description: The communication range between a civilian Unmanned Aerial Vehicle (UAV) and a Ground Control Station (GCS) is affected by the government regulations that determine the use of frequency bands and constrain the amount of power in those frequencies. The application of multiple UAVs in search and rescue operations for example demands a reliable, long-range inter-UAV communication. The inter-UAV communication is the ability of UAVs to exchange data among themselves, thus forming a network in the air. This ability could be used to extend the range of communication by using a decentralized routing technique in the network. To provide this ability to a fleet of autonomous dirigible UAVs being developed at the University of Ottawa, a new communication framework was introduced and implemented. Providing a true mesh networking based on a novel routing protocol, the framework combines long-range radios at 900 MHz Industrial, Scientific and Medical (ISM) band with the software integrated into the electronics platform of each dirigible. With one radio module per dirigible the implemented software provides core functionalities to each UAV, such as exchanging flight control commands, telemetry data, and photos with any other UAV in a decentralized network or with the GCS. We made use of the advanced networking tools of the radio modules to build capabilities into the software for route tracing, traffic prioritization, and minimizing self-interference. Initial test results showed that without acknowledgements, packets can be received in the wrong order and cause errors in the transmission of photos. In addition, a transmission in a presence of a third broadcasting node slows down by 4-6 times. Based on these results our software was improved to control to flow of transmit data making the fragmentation, packetization, and reassembly of photos more reliable. Currently, using radios with half-wavelength dipole antennas we can achieve a one-hop communication range of up to 5 km with the radio frequency line-of-sight (RF LOS). This can be extended further by adding as many radio nodes as needed to act as intermediate hops.
Enhancing the Use of Network Meta-analysis to Synthesize Information on Benefits and Harms of Drugs to Support Regulatory and Reimbursement Decisions in Canada
Creators: name: Cameron, Chris
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Network meta-analysis
Reimbursement
Regulatory
Health
Drugs
Pharmaceuticals

description: BACKGROUND AND OBJECTIVES: Standard meta-analysis compares two treatments whereas network meta-analysis compares multiple treatments. In light of the increasing number of treatments available, we have seen a shift from using standard meta-analysis towards using network meta-analyses to support regulatory and reimbursement decisions. This thesis (composed of nine separate papers) applied network meta-analysis to a series of real world problems which simultaneously addressed many of these methodological issues while also supporting healthcare decision making. METHODS: In the first chapter, background information on network meta-analysis and outline the rationale for each of the subsequent chapters is provided. In Chapter 2, an applied example is presented where we use FDA Public Summary documents to populate a network meta-analysis of antithrombotic therapies for atrial fibrillation. In Chapter 3, the advantages and disadvantages of rapid network meta-analysis using ClinicalTrials.gov are investigated by re-doing Chapter 3 but only using data available in ClinicalTrials.gov and examining concordance. In Chapter 4, the application of network meta-analysis when events are rare are investigated using an illustrative example investigating the risk of serious infection in biologics. In Chapter 5, the application of network meta-analysis to a complex network – triptans for migraine – are presented where there are a large number of studies and treatments. In Chapter 6 a network meta-analysis which assesses both a benefit and harm and integrates findings using a benefit harm methodology is presented. In Chapter 7, methods to incorporate non-randomized studies into network meta-analysis are investigated using data on riskof myocardial infarction derived from the Mini-Sentinel distributed data network. FINDINGS AND CONCLUSION: Pragmatic research around methodological areas in network meta-analysis were conducted to address real world problems for decision makers. It is my hope that this thesis and the approaches used in this thesis for the application of network meta-analysis will be disseminated to enhance research capacity in conducting network meta-analysis in Canada.
On the Conjugacy of Maximal Toral Subalgebras of Certain Infinite-Dimensional Lie Algebras
Creators: name: Gontcharov, Aleksandr
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Lie algebras
representation theory
Bezout domains
Bezout Rings
central extensions
conjugacy problem
direct limit lie algebras
maximal toral subalgebra
cartan subalgebra
finitely generated bezout domain

description: We will extend the conjugacy problem of maximal toral subalgebras for Lie algebras of the form $\g{g} \otimes_k R$ by considering $R=k[t,t^{-1}]$ and $R=k[t,t^{-1},(t-1)^{-1}]$, where $k$ is an algebraically closed field of characteristic zero and $\g{g}$ is a direct limit Lie algebra. In the process, we study properties of infinite matrices with entries in a B\'{e}zout domain and we also look at how our conjugacy results extend to universal central extensions of the suitable direct limit Lie algebras.
Longitudinal Links between Perfectionism and Depression in Children
Creators: name: Asseraf, Marielle
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Depression
Perfectionism
Children
Adolescent
Longitudinal

description: The temporal relationship between two types of perfectionism— self-oriented perfectionism (SOP) and socially prescribed perfectionism (SPP)— and depressive symptoms was examined in a sample of 653 children across Grades 6 (depressive symptoms only), 7, and 8. A vulnerability model, in which perfectionism affects depressive symptoms, was compared to a scar model, in which depressive symptoms affects perfectionism, and to a reciprocal-causality model, in which both constructs concurrently affect each other across time. Cross-lagged paths analyses using structural equation modeling supported a scar model where increases in depressive symptoms lead to increases in SPP, but not SOP. The findings applied to both boys and girls. Results suggest that in childhood, depressive symptoms increase the perception that others are expecting excessively high standards from oneself and the need to satisfy this perception.
Predicting Graft Loss Following Acute Kidney Injury in Patients With a Kidney Transplant
Creators: name: Molnar, Amber
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Acute kidney injury
kidney transplant
Healthcare databases
Risk score

description: Acute kidney injury (AKI), characterized by an abrupt loss of kidney function with retention of nitrogenous waste products, is common in the months to years following kidney transplantation and is associated with an increased risk of transplant failure (graft loss). Kidney transplant patients who experience graft loss and return to dialysis have an increased mortality risk and a lower quality of life. Research involving kidney transplant patients can prove challenging, as they are relatively small in number. To increase statistical power, researchers may utilize administrative databases. However, these databases are not designed primarily for research, and knowledge of their limitations is needed, as significant bias can occur. When using administrative databases to study AKI in kidney transplantation, the method used to define AKI should be carefully considered. The power of a study may be greatly increased if AKI can be accurately defined using administrative diagnostic codes because data on AKI will be universally available for all patients in the database. However, the methods by which diagnostic codes are assigned to a patient allow for error to be introduced. We confirmed that, when compared to the gold standard definition for AKI of a rise in serum creatinine, the diagnostic code for AKI has low sensitivity but high specificity in the kidney transplant population (the best performing coding algorithm had a sensitivity of 42.9% (95% CI 29.7, 56.8) and specificity of 89.3% (95% CI 86.2, 91.8) (Chapter 3). We therefore determined that for the study outlined in Chapter 4, defining AKI using diagnostic codes would significantly under-­capture AKI and misclassify patients. We decided to define AKI using only serum creatinine criteria even though this would limit our sample size (creatinine data was only available for a subset of patients in the administrative databases). In Chapter 4, we derived an index score to predict the risk of graft loss in kidney transplant patients following an admission to hospital with AKI. The index includes six readily available, objective clinical variables that increased the risk of graft loss: increasing age, increased severity of AKI (as defined by the AKIN staging system), failure to recover from AKI, lower baseline estimated glomerular filtration rate, increased time from kidney transplant to AKI admission, and deceased donor. The derived index requires validation in order to assess its utility in the clinical realm.
Australia's strengths and weaknesses in technology transfer and R&D exploitation: GEM survey 'experts' views compared with public policy and other published data
Creators: name: Yencken, John
name: Rushworth, Susan
name: Hindle, Kevin
Publisher: name: Swinburne
Year: 2024

description: There has been increasing public debate in Australia in recent years about research culture in universities and other publicly funded research agencies such as CSIRO and its impact on Australia’s performance in generating economic, social and environmental benefits to the Australian community from the large amount of public funding for R&D. This is the supply side issue. On the demand side there is equally concern about the technology absorptive capacity of Australian business as illustrated by the low proportion of gross business research expenditure (GERD) spent by business (BERD). Against this background, this paper has explored the views of abut 100 “experts” interviewed in the Australian Global Entrepreneurship Monitor (GEM) studies in the years 2000, 2001, 2002 and 2003 on the issues, strengths and weaknesses of Australia’s technology transfer performance as it applies to new technology small firms. The paper has also explored evidence for any longitudinal change over this period.
Le syncrétisme religieux en Égypte dans l'Antiquité tardive : l'apport des papyrus iatromagiques grecs
Creators: name: Bélanger Sarrazin, Roxanne
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Antiquité
Égypte
Religions

description: À une époque où le multiculturalisme est devenu un enjeu important pour les sociétés contemporaines, les historiens ont développé un nouvel intérêt par rapport aux phénomènes de contacts interculturels et de syncrétisme religieux dans l’Antiquité. Les papyrus magiques grecs, produits entre le 2e siècle avant notre ère et le 6e siècle de notre ère, représentent une source idéale pour qui désire étudier les interactions culturelles et le syncrétisme religieux en Égypte, en particulier dans l’Antiquité tardive (4e au 7e siècle de notre ère). Les papyrus iatromagiques plus précisément – des textes magiques ayant pour but de guérir ou prévenir des maladies – présentent un double intérêt puisqu’ils contiennent non seulement des éléments de différentes religions (égyptienne, grecque, romaine, judaïsme et christianisme), mais aussi les riches connaissances médicales des divers peuples qui se sont rencontrés en Égypte. En présentant un examen détaillé du vocabulaire et des connaissances médicales, ainsi que des études de cas de documents contenant divers éléments religieux, cette thèse démontre comment les papyrus iatromagiques grecs reflètent les différents types de syncrétisme religieux présents en Égypte dans l’Antiquité tardive.
Embedding based retrieval for long tail search queries in ecommerce
Creators: name: Kekuda, Akshay
name: Zhang, Yuyang
name: Udayashankar, Arun
Publisher: name: arXiv
Year: 2025
Subjects: subject: Information Retrieval (cs.IR)
subject: FOS: Computer and information sciences

description: In this abstract we present a series of optimizations we performed on the two-tower model architecture [14], training and evaluation datasets to implement semantic product search at Best Buy. Search queries on bestbuy.com follow the pareto distribution whereby a minority of them account for most searches. This leaves us with a long tail of search queries that have low frequency of issuance. The queries in the long tail suffer from very spare interaction signals. Our current work focuses on building a model to serve the long tail queries. We present a series of optimizations we have done to this model to maximize conversion for the purpose of retrieval from the catalog. The first optimization we present is using a large language model to improve the sparsity of conversion signals. The second optimization is pretraining an off-the-shelf transformer-based model on the Best Buy catalog data. The third optimization we present is on the finetuning front. We use query-to-query pairs in addition to query-to-product pairs and combining the above strategies for finetuning the model. We also demonstrate how merging the weights of these finetuned models improves the evaluation metrics. Finally, we provide a recipe for curating an evaluation dataset for continuous monitoring of model performance with human-in-the-loop evaluation. We found that adding this recall mechanism to our current term match-based recall improved conversion by 3% in an online A/B test.
description: Published at RecSys '24: Proceedings of the 18th ACM Conference on Recommender Systems
Asociation of PCSK9 with Low Density Lipoproteins (LDL) in the Regulation of LDL-Cholesterol Levels
Creators: name: Sarkar, Samantha Khadija
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: PCSK9
LDL
lipoprotein
cholesterol

description: Proprotein Convertase Subtilisin / Kexin Type-9 (PCSK9) has emerged as a major regulator of plasma cholesterol levels. PCSK9 is secreted mainly from the liver and circulates as a plasma protein. PCSK9 binds cell surface low-density lipoprotein (LDL) receptors and mediates their degradation upon endocytosis in the liver. This decreases the liver’s ability to clear LDL-cholesterol from the blood. PCSK9 is also capable of binding LDL particles themselves; this interaction inhibits the ability of PCSK9 to bind and mediate LDLR degradation in cultured hepatic cells, but its effect on PCSK9 function in vivo remains unknown. A disordered N-terminal region of the PCSK9 prodomain is necessary for binding to isolated LDL particles in vitro. This N-terminal region is also autoinhibitory to PCSK9-LDL receptor binding. We hypothesized that the N-terminal of the PCSK9 prodomain plays a role in an allosteric mechanism that regulates PCSK9 function. Through mutagenesis studies, we found that both a conserved stretch of acidic residues and an adjacent conserved stretch of hydrophobic residues are crucial for the PCSK9-LDL interaction; the hydrophobicity of the residue at position 38 (Tyr) within the conserved acidic stretch was also found to be important for this. Helical wheel modeling of the prodomain N-terminal sequence revealed the potential for a lipid-ordered amphipathic helix to form, which may aid PCSK9 docking onto LDL. Replacing residues A44 and L41 with helix-disrupting proline residues abolished LDL binding. Co-pelleting ultracentrifugation assays also show that wild-type PCSK9 is capable of associating with liposomes, while the A44P mutation disrupts this lipid association. The A44P-PCSK9 mutation, showing an 80-90% decrease in LDL association but with LDL receptor binding and degrading functions intact, may serve as an important tool in future studies investigating the PCSK9-LDL interaction in vivo. Elucidation of the mechanism by which LDL-binding naturally inhibits PCSK9 activity may also help to develop new anti-PCSK9 therapeutics in the future.
Multi-Scale Graph Learning for Anti-Sparse Downscaling
Creators: name: Fan, Yingda
name: Yu, Runlong
name: Barclay, Janet R.
name: Appling, Alison P.
name: Sun, Yiming
name: Xie, Yiqun
name: Jia, Xiaowei
Publisher: name: arXiv
Year: 2025
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences
subject: I.2.6; I.2.10
subject: 68T05, 68U05

description: Water temperature can vary substantially even across short distances within the same sub-watershed. Accurate prediction of stream water temperature at fine spatial resolutions (i.e., fine scales, $\leq$ 1 km) enables precise interventions to maintain water quality and protect aquatic habitats. Although spatiotemporal models have made substantial progress in spatially coarse time series modeling, challenges persist in predicting at fine spatial scales due to the lack of data at that scale.To address the problem of insufficient fine-scale data, we propose a Multi-Scale Graph Learning (MSGL) method. This method employs a multi-task learning framework where coarse-scale graph learning, bolstered by larger datasets, simultaneously enhances fine-scale graph learning. Although existing multi-scale or multi-resolution methods integrate data from different spatial scales, they often overlook the spatial correspondences across graph structures at various scales. To address this, our MSGL introduces an additional learning task, cross-scale interpolation learning, which leverages the hydrological connectedness of stream locations across coarse- and fine-scale graphs to establish cross-scale connections, thereby enhancing overall model performance. Furthermore, we have broken free from the mindset that multi-scale learning is limited to synchronous training by proposing an Asynchronous Multi-Scale Graph Learning method (ASYNC-MSGL). Extensive experiments demonstrate the state-of-the-art performance of our method for anti-sparse downscaling of daily stream temperatures in the Delaware River Basin, USA, highlighting its potential utility for water resources monitoring and management.
description: AAAI-25, Multi-scale deep learning approach for spatial downscaling of geospatial data with sparse observations
Supplementary document for Development and characterization of disposable sub-millimeter fiberoptic Raman needle probe for real-time in vivo deep tissue and biofluids Raman measurements - 5420481.pdf
Creators: name: Huang, Zhiwei
name: Shu, Chi
name: Zheng, Wei
name: Wang, Zhuo
name: Yu, Changyuan
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary
title: Integrative Krebsmedizin: das Klaus-Bahlsen-Zentrum der MHH
Creators: name: Zorn, Stefan
Publisher: name: Medizinische Hochschule Hannover Bibliothek
Year: 2023
Subjects: subject: 610

description: MHHinfo: Das Magazin der Medizinischen Hochschule Hannover, no. 5
Visual Recognition of a Dynamic Arm Gesture Language for Human-Robot and Inter-Robot Communication
Creators: name: Abid, Muhammad Rizwan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: dynamic arm gesture language
3D HOG descriptor
bag-of-feature (BOF)
local part model
formal language
linear formal grammar
stochastic linear formal grammar
human-robot communication
inter-robot communication

description: This thesis presents a novel Dynamic Gesture Language Recognition (DGLR) system for human-robot and inter-robot communication. We developed and implemented an experimental setup consisting of a humanoid robot/android able to recognize and execute in real time all the arm gestures of the Dynamic Gesture Language (DGL) in similar way as humans do. Our DGLR system comprises two main subsystems: an image processing (IP) module and a linguistic recognition system (LRS) module. The IP module enables recognizing individual DGL gestures. In this module, we use the bag-of-features (BOFs) and a local part model approach for dynamic gesture recognition from images. Dynamic gesture classification is conducted using the BOFs and nonlinear support-vector-machine (SVM) methods. The multiscale local part model preserves the temporal context. The IP module was tested using two databases, one consisting of images of a human performing a series of dynamic arm gestures under different environmental conditions and a second database consisting of images of an android performing the same series of arm gestures. The linguistic recognition system (LRS) module uses a novel formal grammar approach to accept DGL-wise valid sequences of dynamic gestures and reject invalid ones. LRS consists of two subsystems: one using a Linear Formal Grammar (LFG) to derive the valid sequence of dynamic gestures and another using a Stochastic Linear Formal Grammar (SLFG) to occasionally recover gestures that were unrecognized by the IP module. Experimental results have shown that the DGLR system had a slightly better overall performance when recognizing gestures made by a human subject (98.92% recognition rate) than those made by the android (97.42% recognition rate).
Effects of Social Isolation and Loneliness in Children with Neurodevelopmental Disabilities : A Scoping Review
Creators: name: Kwan, Celia
name: Gitimoghaddam, Mojgan
name: Collet, Jean-Paul
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2020

description: Loneliness and social isolation have negative consequences on physical and mental health in both adult and pediatric populations. Children with neurodevelopmental disabilities (NDD) are often excluded and experience more loneliness than their typically developing peers. This scoping review aims to identify the type of studies conducted in children with NDD to determine the effects of loneliness and/or social isolation. Three electronic databases (Ovid MEDLINE, EMBASE, PsychINFO) were searched from inception until 5 February 2019. Two independent reviewers screened the citations for inclusion and extracted data from the included articles. Quantitative (i.e., frequency analysis) and qualitative analyses (i.e., content analysis) were completed. From our search, 5768 citations were screened, 29 were read in full, and 12 were included. Ten were case-control comparisons with cross-sectional assessment of various outcomes, which limited inference. Autism spectrum disorder, attention-deficit/hyperactivity disorder, and learning disorder were the most commonly studied NDD. This review showed that loneliness among children with NDD was associated with negative consequences on mental health, behaviour, and psychosocial/emotional development, with a likely long-term impact in adulthood. Lack of research in this area suggests that loneliness is not yet considered a problem in children with NDD. More studies are warranted using prospective designs and a larger sample size with a focus on the dynamic aspect of loneliness development.
Novel SMAC Mimetics as Peptide-based Small Molecule Inhibitors of IAPs to Induce Apoptosis in Cancer Cells
Creators: name: McClymont, Kyle Stephen
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Medicinal Chemistry
Cancer
Peptide

description: SMAC (Secondary Mitochondria-derived Activator of Caspases) mimetics have generated significant interest as potential chemotherapeutic compounds via their ability to promote apoptosis in cancer cells. These molecules target several Inhibitor of Apoptosis Proteins (IAPs) whose elevated expression is ubiquitous with tumorigenesis. We report several novel SMAC based peptidomimetics which appear to mirror the anti-IAP activity of SMAC in vitro. Elements of reported SMAC mimetics were combined with unique structural features to design novel, efficacious IAP antagonists. Our approach included modifications to the 2nd and 4th residues of the AVPI peptide sequence, the motif responsible for SMAC 's interaction with IAPs. Cell-based compound testing against MDA-MB-231 breast cancer cells identified several promising leads possessing nanomolar cytotoxic effects. Apoptotic activity was confirmed via capsase-3/7 activation, a hallmark of regulated cell death. Our experimental data suggests we have developed selective, potent anti-cancer compounds to be further developed in the pursuit of new anti-cancer therapeutics.
title: "Legarsi" alla famiglia: Esiste un rischio di istituzionalizzazione attraverso lo IESA?
Creators: name: Elgeti, Hermann
Publisher: name: Medizinische Hochschule Hannover Bibliothek
Year: 2021
Subjects: subject: 610

description: Dymphna´s Family - Edizione italiana della revista europea sullo IESA, no. 4, p. 32
Impacts of the EU's common agricultural policy on biodiversity and ecosystem services
Creators: name: Lakner, Sebastian
name: Holst, Carsten
name: Hoyer, Christian
name: Dittrich, Andreas
Publisher: name: My University
Year: 2019
Subjects: EU-Agrarpolitik
Biologische Vielfalt

description: Over the past decades, the EU's Common Agricultural Policy has been supporting farmers. At the same time, one could observe a sharp decline in farmland-biodiversity. © Springer International Publishing AG, part of Springer Nature 2019
Generative AI in clinical practice: novel qualitative evidence of risk and responsible use of Google's NotebookLM
Creators: name: Reuter, Max
name: Philippone, Maura
name: Benton, Bond
name: Dilley, Laura
Publisher: name: arXiv
Year: 2025
Subjects: subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: The advent of generative artificial intelligence, especially large language models (LLMs), presents opportunities for innovation in research, clinical practice, and education. Recently, Dihan et al. lauded LLM tool NotebookLM's potential, including for generating AI-voiced podcasts to educate patients about treatment and rehabilitation, and for quickly synthesizing medical literature for professionals. We argue that NotebookLM presently poses clinical and technological risks that should be tested and considered prior to its implementation in clinical practice.
description: Eye (2025)
Étude des déterminants du savoir-faire physique chez l’enfant
Creators: name: Lizotte, Christian
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Activité physique
comportement quotidien
compétence physique
motivation
confiance
connaissances
compréhension

description: Différents facteurs sont associés avec l’activité physique et le comportement quotidien des enfants. Toutefois, si ces facteurs sont associés au savoir-faire physique (SFP) global de l’enfant est largement méconnu. De ce fait, l’objectif de cette thèse était d’investiguer des facteurs non documentés à ce jour qui ont le potentiel d’influencer le SFP de l’enfant en se servant de l’Évaluation canadienne du savoir-faire physique (ÉCSFP). Les résultats de cette thèse suggèrent que le temps de jeu passé à l’extérieur durant les fins de semaine ainsi que l’utilisation d’un mode de transport actif sont significativement associés au SFP des enfants. Bien que cette étude ne soit que de nature exploratoire et qu’elle ne peut pas démontrer de liens de cause à effet, elle suggère que le SFP de l’enfant peut être influencé par un ensemble de facteurs, certains n’étant pas encore documentés.
Ambush Marketing: A Chinese Perspective
Creators: name: Liu, Yuqi
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: sports sponsorship
China
ambush marketing
experts

description: As one of the top topics in both scholarly and practical fields of sport sponsorship, ambush marketing research usually focuses on protection of the sports sponsor’s rights. Since five years after the 2008 Games, how China performs sponsor protection record after the Olympics should be evaluated. In response to the question, the investigator conducted a qualitative study involving 11 semi-structured interviews of subject-matter experts from various types of organizations in China and an archive content analysis. The interviews aimed at revealing further insights into how ambush campaigns are perceived within China as well as to further its possible sociological and economical causes. Results revealed that although ambush marketing was regulated during the 2008 Olympics, it is still common in China. The current situation of ambush marketing in China is shaped by five factors including: (1) media, (2) legal system, (3) government relationships, (4) event organizers’ experience, and (5) contemporary culture.
Stress-Deformation Theories for the Analysis of Steel Beams Reinforced with GFRP Plates
Creators: name: Phe, Pham Van
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Stress
deformation
steel beam
wide flange beam
reinforced
FRP
plate
shear
non-shear
warping
global
local
closed form solution
finite difference
finite element
verification
strain

description: A theory is developed for the analysis of composite systems consisting of steel wide flange sections reinforced with GFRP plates connected to one of the flanges through a layer of adhesive. The theory is based on an extension of the Gjelsvik theory and thus incorporates local and global warping effects but omits shear deformation effects. The theory captures the longitudinal transverse response through a system of three coupled differential equations of equilibrium and the lateral-torsional response through another system of three coupled differential equations. Closed form solutions are developed and a super-convergent finite element is formulated based under the new theory. A comparison to 3D FEA results based on established solid elements in Abaqus demonstrates the validity of the theory when predicting the longitudinal-transverse response, but showcases its shortcomings in predicting the torsional response of the composite system. The comparison sheds valuable insight on means of improving the theory. A more advanced theory is subsequently developed based on enriched kinematics which incorporates shear deformation effects. The shear deformable theory captures the longitudinal-transverse response through a system of four coupled differential equations of equilibrium and the lateral-torsional response through another system of six coupled differential equations. A finite difference approximation is developed for the new theory and a new finite element formulation is subsequently to solve the new system of equations. A comparison to 3D FEA illustrates the validity of the shear deformable theory in predicting the longitudinal-transverse response as well as the lateral-torsional response. Both theories are shown to be computationally efficient and reduce the modelling and running time from several hours per run to a few minutes or seconds while capturing the essential features of the response of the composite system.
Interrupted Time Series Analysis Techniques in Pharmacovigilance
Creators: name: Prendergast, Tim
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Pharmacovigilance
Interrupted Time Series Analysis

description: This thesis considers an approach to evaluate the effectiveness of risk communications for prescription drugs by performing interrupted time series analysis of prescription drug volumes prior to and after the risk communication date. The paper presents methods for detecting change in the presence of autocorrelation and techniques to reduce bias in estimation. Statistical results and data plots are presented for 63 data series. Size and power of the statistical techniques are considered, and a correspondence analysis between these statistical techniques and a small group of physicians is performed. The methods considered in this thesis correspond weakly with physician sentiment, and exhibit inflated type I errors in the presence of significant autocorrelation.
The Generation and Characterization of the Nrl-/-;Ccdc136+/- Mouse Line to Investigate Cone Photoreceptor Transplantation in Adult Mouse Retinas
Creators: name: Smiley, Sheila
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014

description: Human vision is heavily dependent on cone photoreceptor function and irreversible loss of these cells, caused by retinal degenerative diseases, results in deterioration of central, high acuity vision. Here, I characterized coiled-coil domain containing 136 (Ccdc136) as a cone marker. Ccdc136-/- mice were generated and examined using immunohistochemical and electrophysiological analyses. To investigate cone transplantation, the mice were crossed onto a cone-only neural retina leucine zipper knockout (Nrl-/-) background generating Nrl-/-;Ccdc136+/- donor mice. Ccdc136-/- mice expressed GFP in cone but not rod photoreceptors. Nrl-/-;Ccdc136+/- donor mice had an enriched population of GFP+ cones and showed enhanced cone function, identical to Nrl- /- mice. After transplantation, Nrl-/-;Ccdc136+/- cells migrated successfully into adult recipient retinas. Morphology of integrated cells improved with younger donor age with some integrated cells expressing cone markers. In conclusion, the Nrl-/-;Ccdc136+/- mouse is an appropriate strain to investigate cone photoreceptor transplantation. Future studies aim to improve integration rates to assess vision rescue in degenerated retinas.
Coronavirus Disease-19 : An Interim Evidence Synthesis of the World Association for Infectious Diseases and Immunological Disorders (Waidid)
Creators: name: Abu-Raya, Bahaa
name: Migliori, Giovanni Battista
name: O'Ryan, Miguel
name: Edwards, Kathryn
name: Torres, Antoni
name: Alffenaar, Jan-Willem
name: Märtson, Anne-Grete
name: Centis, Rosella
name: D’Ambrosio, Lia
name: Flanagan, Katie
name: Hung, Ivan
name: Lauretani, Fulvio
name: Leung, Chi Chi
name: Leuridan, Elke
name: Maertens, Kirsten
name: Maggio, Marcello Giuseppe
name: Nadel, Simon
name: Hens, Niel
name: Niesters, Hubert
name: Osterhaus, Albert
name: Pontali, Emanuele
name: Principi, Nicola
name: Silva, Denise Rossato
name: Omer, Saad
name: Spanevello, Antonio
name: Sverzellati, Nicola
name: Tan, Tina
name: Torres-Torreti, Juan Pablo
name: Visca, Dina
name: Esposito, Susanna
Publisher: name: Frontiers in Medicine
Year: 2020

description: Coronavirus disease 2019 (COVID-19) is a rapidly evolving, highly transmissible, and potentially lethal pandemic caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of June 11 2020, more than 7,000,000 COVID-19 cases have been reported worldwide, and more than 400,000 patients have died, affecting at least 188 countries. While literature on the disease is rapidly accumulating, an integrated, multinational perspective on clinical manifestations, immunological effects, diagnosis, prevention, and treatment of COVID-19 can be of global benefit. We aimed to synthesize the most relevant literature and experiences in different parts of the world through our global consortium of experts to provide a consensus-based document at this early stage of the pandemic.
Describing the characteristics and healthcare use of high-cost acute care users at the end of life: a pan-Canadian population-based study
Creators: name: Qureshi, Danial
name: Isenberg, Sarina
name: Tanuseputro, Peter
name: Moineddin, Rahim
name: Quinn, Kieran
name: Meaney, Christopher
name: McGrail, Kimberlyn M.
name: Seow, Hsien
name: Webber, Colleen
name: Fowler, Robert
name: Hsu, Amy
Publisher: name: BioMed Central
Year: 2020

description: Background A minority of individuals use a large portion of health system resources, incurring considerable costs, especially in acute-care hospitals where a significant proportion of deaths occur. We sought to describe and contrast the characteristics, acute-care use and cost in the last year of life among high users and non-high users who died in hospitals across Canada. Methods We conducted a population-based retrospective-cohort study of Canadian adults aged ≥18 who died in hospitals across Canada between fiscal years 2011/12–2014/15. High users were defined as patients within the top 10% of highest cumulative acute-care costs in each fiscal year. Patients were categorized as: persistent high users (high-cost in death year and year prior), non-persistent high users (high-cost in death year only) and non-high users (never high-cost). Discharge abstracts were used to measure characteristics and acute-care use, including number of hospitalizations, admissions to intensive-care-unit (ICU), and alternate-level-of-care (ALC). Results We identified 191,310 decedents, among which 6% were persistent high users, 41% were non-persistent high users, and 46% were non-high users. A larger proportion of high users were male, younger, and had multimorbidity than non-high users. In the last year of life, persistent high users had multiple hospitalizations more often than other groups. Twenty-eight percent of persistent high users had ≥2 ICU admissions, compared to 8% of non-persistent high users and only 1% of non-high users. Eleven percent of persistent high users had ≥2 ALC admissions, compared to only 2% of non-persistent high users and < 1% of non-high users. High users received an in-hospital intervention more often than non-high users (36% vs. 19%). Despite representing only 47% of the cohort, persistent and non-persistent high users accounted for 83% of acute-care costs. Conclusions High users – persistent and non-persistent – are medically complex and use a disproportionate amount of acute-care resources at the end of life. A greater understanding of the characteristics and circumstances that lead to persistently high use of inpatient services may help inform strategies to prevent hospitalizations and off-set current healthcare costs while improving patient outcomes.
Photonic Integrated Circuit Architecture for Radio-over-Fibre Applications
Creators: name: Hasan, Mehedi
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Radio-over-Fibre
Photonic Integrated Circuit

description: The aim of the research presented in this thesis is to develop photonic integrated circuit (PIC) for Radio-over-Fiber (RoF) application. As such, at the beginning of the thesis, a dual-function photonic integrated circuit for microwave photonic applications is proposed. The photonic circuit is arranged to have two separate output ports, and depending upon the RF input signal strength, it provides either tunable millimeter wave carriers by frequency octo-tupling of the RF signal or frequency up-conversion of a microwave signal from the electrical to the optical domain. The circuit exploits the intrinsic relative phases between the ports of multi-mode interference couplers (MMI) to provide all the static optical phases needed, hence drift free. In the middle of thesis, a generalized architecture having N parallel phase modulators driven electrically with a progressive 2π⁄N phase shift is analyzed. The proposed design is justified by computer simulation for N=8 architecture with properly determined optical phase shifts to generate frequency multiplication of an electrical signal. The front- and back-end of the circuit comprises 4×4 MMI couplers enclosing an array of four pairs of phase modulators and 2×2 MMI couplers. The proposed design for frequency multiplication requires no optical or electrical filters; the operation is not limited to carefully adjusted modulation indexes. Later on, a generalized approach for achieving frequency multiplication using two cascades MZM is presented. The proposed design consists of a Mach-Zehnder interferometer with each arm containing a pair of Mach-Zehnder modulators (MZM) in series as a means of optoelectronic frequency multiplication (octo-tupling and quattourviginti-tupling). The circuit requires no electrical or optical filters. There is no requirement to carefully adjust the modulation index to achieve correct operation of the octo-tupler. A comparison is made with an alternative functionally equivalent single-stage parallel MZM circuit discussed herein the thesis. Finally, the thesis describes the generation of the same magnitude but opposite sign high order single optical side band from its output ports by using a RF source. A single stage parallel Mach-Zehnder Modulator (MZM) and a two-stage series parallel MZM architecture is described and their relative merits and demerits discussed. As an illustration of a prospective application it is shown how the circuit may be used to transport radio signals over fibre for wireless access; generating remotely a mm-wave carrier modulated by digital IQ data. A detail calculation of symbol error rate is presented to characterise the system performance. A mathematical analysis is provided to describe the principle of operation for all the proposed design and validated by commercially available industrial standard simulation tool.