cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
SUR UN SYLLIDIEN DES EAUX POLLUÉES DU PORT DE LIVOURNE : SYLLIDES EDENTULA CLAPARÈDE
Creators: name: COGNETTI-VARRIALE, Anna-Maria
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1971

description: A population of Syllides edentula is present in very polluted waters of the port of Leghorn. The individuals collected show some little differences with the individuals of the populations of sandy bottoms.
The complet reproductive cycle of some individuals was obtained in laboratory: the larval stages are absent.
Probably it deals with a subspecies differentiated in very polluted areas, so that this form can be included in the number of those polychetes indicators of marine pollution.
title: Emergency evaluation of suspected subarachnoid haemorrhage in a non-neurosurgical centre
Creators: name: Zhong, Edward
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Cerebrospinal fluid
subject: Aneurysms
subject: Acute
subject: Decision analysis
subject: Diagnostic procedure
subject: CT-Angiography
subject: CT
subject: Vascular
subject: Emergency
subject: CNS

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Subarachnoid haemorrhage (SAH) is associated with high morbidity and mortality and is considered one of the most concerning causes of an acute headache.[1,2] Non-contrast computed topography (NCCT) of the brain is the initial investigation of choice...
Nodal Signaling Regulates the Bone Morphogenic Protein Pluripotency Pathway in Mouse Embryonic Stem Cells
Creators: name: Vivian, Jay L.
name: Yee, Della
name: Magnuson, Terry
name: Travis, Emily D.
name: Galvin, Katherine E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Members of the transforming growth factor-β superfamily play essential roles in both the pluripotency and differentiation of embryonic stem (ES) cells. Although bone morphogenic proteins (BMPs) maintain pluripotency of undifferentiated mouse ES cells, the role of autocrine Nodal signaling is less clear. Pharmacological, molecular, and genetic methods were used to further understand the roles and potential interactions of these pathways. Treatment of undifferentiated ES cells with SB431542, a pharmacological inhibitor of Smad2 signaling, resulted in a rapid reduction of phosphorylated Smad2 and altered the expression of several putative downstream targets. Unexpectedly, inhibition of the Nodal signaling pathway resulted in enhanced BMP signaling, as assessed by Smad1/5 phosphorylation. SB431542-treated cells also demonstrated significant induction of the Id genes, which are known direct targets of BMP signaling and important factors in ES cell pluripotency. Inhibition of BMP signaling decreased the SB431542-mediated phosphorylation of Smad1/5 and induction of Id genes, suggesting that BMP signaling is necessary for some Smad2-mediated activity. Because Smad7, a known inhibitory factor to both Nodal and BMP signaling, was down-regulated following inhibition of Nodal-Smad2 signaling, the contribution of Smad7 to the cross-talk between the transforming growth factor-β pathways in ES cells was examined. Biochemical manipulation of Smad7 expression, through shRNA knockdown or inducible gene expression, significantly reduced the SB431542-mediated phosphorylation of Smad1/5 and induction of the Id genes. We conclude that autocrine Nodal signaling in undifferentiated mouse ES cells modulates the vital pluripotency pathway of BMP signaling.
Topological phase transition in wire medium enables high Purcell factor at infrared frequencies
Creators: name: Mirmoosa, M. S.
name: Kosulnikov, S. Yu.
name: Simovski, C. R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: In this paper, we study topological phase transition in a wire medium operating at infrared frequencies. This transition occurs in the reciprocal space between the indefinite (open-surface) regime of the metamaterial to its dielectric (closed-surface) regime. Due to the spatial dispersion inherent to wire medium, a hybrid regime turns out to be possible at the transition frequency. Both such surfaces exist at the same frequency and touch one another. At this frequency, all values of the axial wavevector correspond to propagating spatial harmonics. The implication of this regime is the overwhelming radiation enhancement. We numerically investigated the gain in radiated power for a sub-wavelength dipole source submerged into such the medium. In contrast to all previous works, this gain (called the Purcell factor) turns out to be higher for an axial dipole than for a transversal one.
Additional file 1 of A home-based, multidisciplinary liver optimisation programme for the first 28 days after an admission for acute-on-chronic liver failure (LivR well): a study protocol for a randomised controlled trial
Creators: name: Ngu, Natalie LY
name: Saxby, Edward
name: Worland, Thomas
name: Anderson, Patricia
name: Stothers, Lisa
name: Figredo, Anita
name: Hunter, Jo
name: Elford, Alexander
name: Ha, Phil
name: Hartley, Imogen
name: Roberts, Andrew
name: Seah, Dean
name: Tambakis, George
name: Liew, Danny
name: Rogers, Benjamin
name: Sievert, William
name: Bell, Sally
name: Le, Suong
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. WHO Trial Registration.
p38MAPK Signaling and Desmoglein-3 Internalization Are Linked Events in Pemphigus Acantholysis
Creators: name: Berkowitz, Paula
name: Lee, Hua En
name: Diazr, Luis A.
name: Jolly, Puneet S.
name: Bektas, Meryem
name: Rubenstein, David S.
name: Chua, Michael
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Pemphigus vulgaris (PV) is an autoimmune blistering disease in which antibodies against the desmosomal cadherin, DSG3 (desmoglein-3), cause acantholysis. It has become increasingly clear that loss of cell-cell adhesion in PV is a complex and active process involving multiple signaling events such as activation of p38MAPK. It has also been demonstrated that incubating keratinocytes with PV IgG causes a redistribution of DSG3 from the cell surface to endosomes, which target these proteins for degradation. This study was undertaken to determine the relationship between p38MAPK and DSG3 endocytosis in pemphigus. In this work, we confirm that PV IgG causes internalization of cell-surface DSG3 into endosomes (as early as 4 h), which are then depleted from both detergent-soluble and detergent-insoluble pools. Cell-surface DSG3 internalization and depletion from both the detergent-soluble and detergent-insoluble fractions were blocked by the p38MAPK inhibitor SB202190. These data suggest that p38MAPK is capable of regulating PV IgG-mediated DSG3 internalization and that previously isolated mechanistic observations may be linked to a common pathway by which pemphigus autoantibodies lead to acantholysis.
p66 shc Inhibits Insulin-like Growth Factor-I Signaling via Direct Binding to Src through Its Polyproline and Src Homology 2 Domains, Resulting in Impairment of Src Kinase Activation
Creators: name: Clemmons, David R.
name: Shen, Xinchun
name: Xi, Gang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: p66shc is increased in response to cell stress, and these increases regulate growth factor actions. These studies were conducted to determine how p66shc alters IGF-I-stimulated Src activation, leading to decreased IGF-I actions. Our results show that p66shc binds to Src through a polyproline sequence motif contained in the CH2 domain, a unique domain in p66shc, and IGF-I stimulates this interaction. Disruption of this interaction using a synthetic peptide containing the p66shc polyproline domain or expression of a p66shc mutant containing substitutions for the proline residues (P47A/P48A/P50A) resulted in enhanced Src kinase activity, p52shc phosphorylation, MAPK activation, and cell proliferation in response to IGF-I. To determine the mechanism of inhibition, the full-length CH2 domain and intact p66shc were tested for their ability to directly inhibit Src kinase activation in vitro. The CH2 domain peptide was clearly inhibitory, but full-length p66shc had a greater effect. Deletion of the C-terminal Src homology 2 domain in p66shc reduced its ability to inhibit Src kinase activation. These findings demonstrate that p66shc utilizes a novel mechanism for modulating Src kinase activation and that this interaction is mediated through both its collagen homologous region 2 and Src homology 2 domains.
PB1 Domain Interaction of p62/Sequestosome 1 and MEKK3 Regulates NF-κB Activation
Creators: name: Kimple, Adam J.
name: Siderovski, David P.
name: Johnson, Gary L.
name: Nakamura, Kazuhiro
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: p62/Sequestosome 1 is a scaffold protein involved in the regulation of autophagy, trafficking of proteins to the proteasome, and activation of NF-κB. p62 encodes an N-terminal PB1 domain in addition to the ZZ domain, TRAF6-binding domain, LC3 interaction region, and ubiquitin-associated domain, each critical for the physiological function of p62. PB1 domains have a β-grasp topology where the front end of one PB1 domain binds the back end of a second PB1 domain. The p62 PB1 domain homodimerizes as well as heterodimerizes with other PB1 domains. The front end of the PB1 domain in p62 binds the PB1 domain of atypical protein kinases C, the MAPK kinase, MEK5, and the NBR1 protein. Other than its role in homodimerization, the rear end acidic cluster region of the p62 PB1 domain had no previous defined binding partners. Herein, we demonstrate that the rear end acidic cluster region of the p62 PB1 domain binds the front end basic region of the MAPK kinase kinase, MEKK3. p62 and MEKK3 co-localize in speckles or aggregates that are centers for organizing TRAF6-regulated NF-κB signaling and the assembly of polyubiquinated proteins sorting to sequestosomes and proteasomes. The p62-MEKK3 complex binds TRAF6, which regulates the ubiquitination of the IKK complex and NF-κB activation. p62 is required for the association of MEKK3 with TRAF6 and short hairpin RNA knockdown of p62 inhibits IL-1 and MEKK3 activation of NF-κB. The rear end acidic cluster of the p62 PB1 domain is used to organize cytosolic aggregates or speckles-associated TRAF6-p62-MEKK3 complex for control of NF-κB activation.
Genetic and phenotypic identification of Tylosurus acus imperialis in Thermaikos Gulf, North Aegean Sea
Creators: name: IMSIRIDOU, Anastasia
name: MINOS, George
name: KOKOKIRIS, Lambros
name: ALEXANDROU, Maria
name: KYRIAKIDOU, Maria
name: KARIDAS, Theofanis
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2016

description: Genetic and phenotypic characters were used to identify large-sized needlefish harvested during summer at a fishing ground in Thermaikos Gulf, North Aegean Sea. A single haplotype was found among five individuals, using a 558 bp nucleotide sequence of the 16S rDNA gene of mtDNA. Results of a BLAST engine showed a 99% percentage of maximum identity with agujon needlefish, Tylosurus acus imperialis (Rafinesque, 1810). In the maximum likelihood topology, the sequence of the examined specimens was grouped with those of T. acus sequences, having a bootstrap value of 86%. Morphometric analysis on 112 individuals confirmed the species identity, and rejected several other possible Tylosurus congeners, specifically T. choram and T. crocodilus. Molecular, morphometric and meristic data confirmed the occurrence of T. acus imperialis in this northern location of the Mediterranean Sea.
¿Cómo procesar datos textuales? Introducción a los modelos de lenguaje basados en redes neuronales
Creators: name: Garzón, Andrea Morales
Publisher: name: Zenodo
Year: 2023
Subjects: NLP, transformers, python

description: Presentation of the Talk called "¿Cómo procesar datos textuales? Introducción a los modelos de lenguaje basados en redes neuronales" from the first edition of Pydata Granada
Fatty acid composition of the fillet of wild and farmed sea bream Sparus aurata Linnaeus, 1758 in Tunisian coasts: A comparative study
Creators: name: HAJJI, Tarek
name: RABEH, Imen
name: TELAHIGUE, Khaoula
name: EL CAFSI, MHamed
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2016

description: Gilthead sea bream Sparus aurata is one of the most commonly farmed marine species in the Mediterranean Sea. In Tunisia, this aquaculture product is economically affordable for the consumers; however its nutritional properties are not well documented. This study aims to establish a comparative analysis of the fatty acid profiles of the fillet of wild and farmed sea bream from Tunisian coast. Samples of wild and floating net cage farmed sea bream were obtained in the same season. Fatty acid composition and lipid quality indices were assessed. The obtained results show no significant difference in terms of total fatty acid composition between samples from intensive farming in floating net cages and wild fish. However, the samples from the farming net cages were characterized by significantly higher levels of docosahexaenoic acid (C22:6n-3) and linoleic acid (C18:2n-6) against high levels of arachidonic acid (C20:4n-6), eicosapentaenoic acid (C20:5n- 3) and α-linolenic acid (C18:3n-3) in wild specimens. From a nutritional point of view, the docosahexaenoic acid content and the values of some indicators of the nutritional quality of lipids such as the flesh lipid quality (FLQ) and the thrombogenic index (TI) show slightly higher nutritional value of farmed vs. wild gilthead.
title: Hypertrophic olivary degeneration: anatomy, aetiology and neuroimaging
Creators: name: Gaillard, Frank
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Anatomy
subject: Neuroradiology brain
subject: CNS
subject: MR
subject: Imaging sequences
subject: Education and training
subject: Haemorrhage

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: To discuss the radiological features of hypertrophic olivary degeneration (HOD), with emphasis on underlying neuroanatomy. In this poster, we review the relevant anatomy, pathophysiology, time-course and range of imaging...
Additional file 2 of A home-based, multidisciplinary liver optimisation programme for the first 28 days after an admission for acute-on-chronic liver failure (LivR well): a study protocol for a randomised controlled trial
Creators: name: Ngu, Natalie LY
name: Saxby, Edward
name: Worland, Thomas
name: Anderson, Patricia
name: Stothers, Lisa
name: Figredo, Anita
name: Hunter, Jo
name: Elford, Alexander
name: Ha, Phil
name: Hartley, Imogen
name: Roberts, Andrew
name: Seah, Dean
name: Tambakis, George
name: Liew, Danny
name: Rogers, Benjamin
name: Sievert, William
name: Bell, Sally
name: Le, Suong
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2. SPIRIT Checklist.
title: NFI (Non full-time interventionist) guide to musculoskeletal intervention
Creators: name: Croft, Michael
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Interventional non-vascular
subject: Musculoskeletal system
subject: Musculoskeletal joint
subject: Ultrasound
subject: CT
subject: Education
subject: Safety
subject: Education and training

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: This poster aims to provide education and instruction for commonly performed image guided musculoskeletal procedures for the general and trainee radiologist. Improve understanding of commonly performed interventional procedures. Improve confidence...
PDK1 Recruitment to the SHPS-1 Signaling Complex Enhances Insulin-like Growth Factor-I-stimulated AKT Activation and Vascular Smooth Muscle Cell Survival
Creators: name: Radhakrishnan, Yashwanth
name: Shen, Xinchun
name: Clemmons, David R.
name: Xi, Gang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: In vascular smooth muscle cells, exposed to hyperglycemia and insulin-like growth factor-I (IGF-I), SHPS-1 functions as a scaffold protein, and a signaling complex is assembled that leads to AKT activation. However, the underlying mechanism by which formation of this complex activates the kinase that phosphorylates AKT (Thr308) is unknown. Therefore, we investigated the mechanism of PDK1 recruitment to the SHPS-1 signaling complex and the consequences of disrupting PDK1 recruitment for downstream signaling. Our results show that following IGF-I stimulation, PDK1 is recruited to SHPS-1, and its recruitment is mediated by Grb2, which associates with SHPS-1 via its interaction with Pyk2, a component of the SHPS-1-associated complex. A proline-rich sequence in PDK1 bound to an Src homology 3 domain in Grb2 in response to IGF-I. Disruption of Grb2-PDK1 by expression of either a Grb2 Src homology 3 domain or a PDK1 proline to alanine mutant inhibited PDK1 recruitment to SHPS-1, leading to impaired IGF-I-stimulated AKT Thr308 phosphorylation. Following its recruitment to SHPS-1, PDK1 was further activated via Tyr373/376 phosphorylation, and this was required for a maximal increase in PDK1 kinase activity and AKT-mediated FOXO3a Thr32 phosphorylation. PDK1 recruitment was also required for IGF-I to prevent apoptosis that occurred in response to hyperglycemia. Assembly of the Grb2-PDK1 complex on SHPS-1 was specific for IGF-I signaling because inhibiting PDK1 recruitment to SHPS-1 had no effect on EGF-stimulated AKT Thr308 phosphorylation. These findings reveal a novel mechanism for recruitment of PDK1 to the SHPS-1 signaling complex, which is required for IGF-I-stimulated AKT Thr308 phosphorylation and inhibition of apoptosis.
title: 材料データプラットフォームDICE2.0 - データ創出−蓄積−利用−連携の基盤
Creators: name: tanifuji, mikiko
name: Matsuda, Asahiko
name: YOSHIKAWA, Hideki
Publisher: name: NIMS
Year: 2022
Subjects: 研究データ
データフロー
FAIR
DICE
マテリアル・インフォマティクス
語彙管理
データ構造化

description: 材料分野でのデータ駆動型の材料研究の進展のため、物質 ･ 材料研究機構（National Institute for Materials Science, NIMS）は材料データプラットフォームシステムの開発に 2017 年に着手し、2020年からサービス名 DICE として所内展開を開始した。この取り組みをさらに全国利用へ向けたデータ中核拠点へと推進していくDICE2.0構想を紹介し、データ連携へ向けての課題、要素技術として語彙管理MatVoc、データ活用のための可視化・構造化・モデル化について、事例紹介を交えて考察する。
Formation and Thermal Stability of Gold-Silica Nanohybrids: Insight into the Mechanism and Morphology by Electron Tomography
Creators: name: Kundu, Paromita
name: Heidari, Hamed
name: Bals, Sara
name: Ravishankar, N.
name: Van Tendeloo, Gustaaf
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Gold-silica hybrids are appealing in different fields of applications like catalysis, sensors, drug delivery, and biotechnology. In most cases, the morphology and distribution of the hetero-units play significant roles in their functional behavior. Methods of synthesizing these hybrids, with variable ordering of the hetero-units, are replete; however, a complete characterization in three dimensions could not be achieved yet. A simple route to the synthesis of Au-decorated SiO2 spheres is demonstrated and a study on the 3D ordering of the hetero-units by scanning transmission electron microscopy (STEM) tomography is presented at the final stage, intermediate stages of formation, and after heating the hybrid. The final hybrid evolves from a soft self-assembled structure of Au nano-particles. The hybrid shows good thermal stability up to 400 C, beyond which the Au particles start migrating inside the SiO2 matrix. This study provides an insight in the formation mechanism and thermal stability of the structures which are crucial factors for designing and applying such hybrids in fields of catalysis and biotechnology. As the method is general, it can be applied to make similar hybrids based on SiO2 by tuning the reaction chemistry as needed.
title: Radiology teaching for interns: current practice, self-reported confidence in interpretation of medical imaging and cohort needs analysis for radiology education
Creators: name: Glenn-Cox, Sophie
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Professional issues
subject: Plain radiographic studies
subject: CT
subject: Ultrasound
subject: Education
subject: eLearning
subject: Education and training

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: The importance of undergraduate radiology teaching has been highlighted in European studies. 1,2 This is supported by studies on undergraduates andjunior doctors which have found that radiology teaching they receive leaves them feeling unprepared...
Additional file 3 of A home-based, multidisciplinary liver optimisation programme for the first 28 days after an admission for acute-on-chronic liver failure (LivR well): a study protocol for a randomised controlled trial
Creators: name: Ngu, Natalie LY
name: Saxby, Edward
name: Worland, Thomas
name: Anderson, Patricia
name: Stothers, Lisa
name: Figredo, Anita
name: Hunter, Jo
name: Elford, Alexander
name: Ha, Phil
name: Hartley, Imogen
name: Roberts, Andrew
name: Seah, Dean
name: Tambakis, George
name: Liew, Danny
name: Rogers, Benjamin
name: Sievert, William
name: Bell, Sally
name: Le, Suong
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 3. LivR Well standardised admission checklist.
title: Review of CT Imaging features in renal trauma correlated to the American Association for the Surgery of Trauma (AAST) Organ Injury Scale
Creators: name: Brennan, Tommy
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Trauma
subject: Kidney
subject: Abdomen
subject: CT
subject: Staging
subject: Surgery
subject: Education
subject: Trauma
subject: Haemorrhage
subject: Education and training

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: To identify the imaging characteristics of renal trauma and correlate these findings with the American Association for the Surgery of Trauma (AAST) organ injury scale and thus improve the recognition of renal trauma, and to standardise the reporting...
Trigonometric time integrators for the Zakharov system
Creators: name: Herr, Sebastian
name: Schratz, Katharina
Publisher: name: arXiv
Year: 2015
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: The main challenge in the analysis of numerical schemes for the Zakharov system originates from the presence of derivatives in the nonlinearity. In this paper a new trigonometric time-integration scheme for the Zakharov system is constructed and convergence is proved. The time-step restriction is independent from a spatial discretization. Numerical experiments confirm the findings.
Preferential Selection of the 5′-Terminal Start Codon on Leaderless mRNAs by Mammalian Mitochondrial Ribosomes
Creators: name: Spremulli, Linda L.
name: Christian, Brooke E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Mammalian mitochondrial mRNAs are basically leaderless, having few or no untranslated nucleotides prior to the 5′-start codon. We demonstrate here that mammalian mitochondrial 55 S ribosomes preferentially form initiation complexes at a 5′-terminal AUG codon over an internal AUG. The preferential use of the 5′-start codon is also seen on mitochondrial 28 S small subunits, which suggests that mitochondrial translation initiation on leaderless mRNAs does not require the large ribosomal subunit. The selection of the 5′-AUG is dependent on the presence of fMet-tRNA and is enhanced by the presence of the mitochondrial initiation factor IF2mt. In prokaryotes, IF3 is believed to antagonize initiation on leaderless mRNAs. However, IF3mt stimulates initiation complex formation on leaderless mRNAs when tested with 55 S ribosomes. The addition of even a few nucleotides 5′ to the AUG codon significantly reduces the efficiency of initiation, highlighting the importance of the leaderless or nearly leaderless nature of mitochondrial mRNAs. In addition, very few initiation complexes could form on a hybrid mRNA construct consisting of tRNAMet attached at the 5′-end of a mitochondrial protein-coding sequence. This observation demonstrates that post-transcriptional processing must occur prior to translation in mammalian mitochondria.
title: Causes, pathology, radiological findings and clinical consequences of superficial siderosis
Creators: name: Fielder, Matthew
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Education
subject: MR
subject: CNS
subject: Neuroradiology spine
subject: Neuroradiology brain
subject: Haemorrhage

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: To improve knowledge of causes, pathology, diagnosis and clinical presentation of superficial siderosis. To outline the radiological findings of superficial siderosis using case...
CONTRIBUTION A L'ÉTUDE DES CTÉNOPHORES PLATYCTÉNIDES DE MADAGASCAR : CTENOPLANA (DIPLOCTENA N. S. GEN.) NERITICA N.SP. ET COELOPLANA (BENTHOPLANA N.S.GEN.) METEORIS (THIEL 1968)
Creators: name: H.W.FRICKE, H.W.Fricke
name: PLANTE, R.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1971

description: The authors give a discussion of the taxonomie position of two species of Platyctenid Ctenophores, collected near Nosy-Bé (Madgascar). Some important features of their behaviour are described.
ÉTUDE DU DÉVELOPPEMENT D'HALISTEMMA RUBRUM (VOGT, 1852) SIPHONOPHORE PHYSONECTE AGALMIDAE
Creators: name: CARRÉ, Daniele
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1971

description: Metschnikoff (1874) and Woltereck (1905) gave two contradictory descriptions of the morphology of the development of the Siphonophora Physonectae Halis- temma rubrum (Vogt, 1852). The author confirms the observations of Metchnikoff and studies the histology of the main larval stages. He shows that segmentation does not lead to a morula, contrary to general opinion, but to a blastula of a particular type which changes into a gastrula by a primary delamination. At the planula stage an ectodermal invagination gives the bud of pneumatophore which in the neighbourhood of this organ, a swimming bell develops from a medusal nodule, isolated by delamination of the ectoderm.
The author compares development of the pneumatophore with that of the nectophore and concludes that these two organs have different modes of differentiation which preclude any homology between them.
Nodal surfaces and interdimensional degeneracies
Creators: name: Loos, Pierre-François
name: Bressanini, Dario
Publisher: name: arXiv
Year: 2015
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Other Condensed Matter (cond-mat.other)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: The aim of this paper is to shed light on the topology and properties of the nodes (i.e. the zeros of the wave function) in electronic systems. Using the "electrons on a sphere" model, we study the nodes of two-, three- and four-electron systems in various ferromagnetic configurations ($sp$, $p^2$, $sd$, $pd$, $p^3$, $sp^2$ and $sp^3$). In some particular cases ($sp$, $p^2$, $sd$, $pd$ and $p^3$), we rigorously prove that the non-interacting wave function has the same nodes as the exact (yet unknown) wave function. The number of atomic and molecular systems for which the exact nodes are known analytically is very limited and we show here that this peculiar feature can be attributed to interdimensional degeneracies. Although we have not been able to prove it rigorously, we conjecture that the nodes of the non-interacting wave function for the $sp^3$ configuration are exact.
description: 7 pages, 3 figures, accepted for publication in the Journal of Chemical Physics
Properties of the C-terminal Tail of Human Mitochondrial Inner Membrane Protein Oxa1L and Its Interactions with Mammalian Mitochondrial Ribosomes
Creators: name: Koc, Emine C.
name: Spremulli, Linda L.
name: Tripathy, Ashutosh
name: Haque, Md Emdadul
name: Elmore, Kevin B.
name: Koc, Hasan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: In humans the mitochondrial inner membrane protein Oxa1L is involved in the biogenesis of membrane proteins and facilitates the insertion of both mitochondrial- and nuclear-encoded proteins from the mitochondrial matrix into the inner membrane. The C-terminal ∼100-amino acid tail of Oxa1L (Oxa1L-CTT) binds to mitochondrial ribosomes and plays a role in the co-translational insertion of mitochondria-synthesized proteins into the inner membrane. Contrary to suggestions made for yeast Oxa1p, our results indicate that the C-terminal tail of human Oxa1L does not form a coiled-coil helical structure in solution. The Oxa1L-CTT exists primarily as a monomer in solution but forms dimers and tetramers at high salt concentrations. The binding of Oxa1L-CTT to mitochondrial ribosomes is an enthalpy-driven process with a Kd of 0.3–0.8 μm and a stoichiometry of 2. Oxa1L-CTT cross-links to mammalian mitochondrial homologs of the bacterial ribosomal proteins L13, L20, and L28 and to mammalian mitochondrial specific ribosomal proteins MRPL48, MRPL49, and MRPL51. Oxa1L-CTT does not cross-link to proteins decorating the conventional exit tunnel of the bacterial large ribosomal subunit (L22, L23, L24, and L29).
ESTIMATING SECONDARY PRODUCTION FOR THE BRACKISH WESTERSCHELDE COPEPOD POPULATION EURYTEMORA-AFFINIS (POPPE) COMBINING EXPERIMENTAL-DATA AND FIELD OBSERVATIONS
Creators: name: Escaravage, V.
name: Soetaert, K.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1993

description: Eurytemora affinis (Poppe) (Copepoda : Calanoida) development is studied through cultures supplied with naturally occurring particulate matter (Western Schelde estuary) and kept at six constant temperatures in the range 2-20-degrees-C. At 2-degrees-C the copepods do not reach the copepodite stages and at 5-degrees-C, do not develop further than the fourth copepodite stage. A field production estimate is given combining the biomass present in the field and weight specific growth rates derived from the culture experiment. The P/B obtained are very close with those measured for the same species in other estuaries.
Linear forms of the telegraph random processes driven by partial differential equations
Creators: name: Kolesnik, Alexander D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60G50, 60J60, 35G10, 35G05, 35L55, 60E10

description: Consider $n$ independent Goldstein-Kac telegraph processes $X_1(t), \dots ,X_n(t), \; n\ge 2, \; t\ge 0,$ on the real line $\Bbb R$. Each the process $X_k(t), \; k=1,\dots,n,$ describes a stochastic motion at constant finite speed $c_k>0$ of a particle that, at the initial time instant $t=0$, starts from some initial point $x_k^0=X_k(0)\in\Bbb R$ and whose evolution is controlled by a homogeneous Poisson process $N_k(t)$ of rate $λ_k>0$. The governing Poisson processes $N_k(t), \; k=1,\dots,n,$ are supposed to be independent as well. Consider the linear form of the processes $X_1(t), \dots ,X_n(t), \; n\ge 2,$ defined by $$L(t) = \sum_{k=1}^n a_k X_k(t) ,$$ where $a_k, \; k=1,\dots,n,$ are arbitrary real non-zero constant coefficients. We obtain a hyperbolic system of first-order partial differential equations for the joint probability densities of the process $L(t)$ and of the directions of motions at arbitrary time $t>0$. From this system we derive a partial differential equation of order $2^n$ for the transition density of $L(t)$ in the form of a determinant of a block matrix whose elements are the differential operators with constant coefficients. The weak convergence of $L(t)$ to a homogeneous Wiener process, under Kac's scaling conditions, is proved. Initial-value problems for the transition densities of the sum and difference $S^{\pm}(t)=X_1(t) \pm X_2(t)$ of two independent telegraph processes with arbitrary parameters, are also posed.
description: 23 pages
Additional file 4 of A home-based, multidisciplinary liver optimisation programme for the first 28 days after an admission for acute-on-chronic liver failure (LivR well): a study protocol for a randomised controlled trial
Creators: name: Ngu, Natalie LY
name: Saxby, Edward
name: Worland, Thomas
name: Anderson, Patricia
name: Stothers, Lisa
name: Figredo, Anita
name: Hunter, Jo
name: Elford, Alexander
name: Ha, Phil
name: Hartley, Imogen
name: Roberts, Andrew
name: Seah, Dean
name: Tambakis, George
name: Liew, Danny
name: Rogers, Benjamin
name: Sievert, William
name: Bell, Sally
name: Le, Suong
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 4. PICF.
Proteolytic Cleavage of Human Acid-sensing Ion Channel 1 by the Serine Protease Matriptase
Creators: name: Jovov, Biljana
name: Clark, Edlira B.
name: Fuller, Catherine M.
name: Benos, Dale J.
name: Rooj, Arun K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Acid-sensing ion channel 1 (ASIC1) is a H+-gated channel of the amiloride-sensitive epithelial Na+ channel (ENaC)/degenerin family. ASIC1 is expressed mostly in the central and peripheral nervous system neurons. ENaC and ASIC function is regulated by several serine proteases. The type II transmembrane serine protease matriptase activates the prototypical αβγENaC channel, but we found that matriptase is expressed in glioma cells and its expression is higher in glioma compared with normal astrocytes. Therefore, the goal of this study was to test the hypothesis that matriptase regulates ASIC1 function. Matriptase decreased the acid-activated ASIC1 current as measured by two-electrode voltage clamp in Xenopus oocytes and cleaved ASIC1 expressed in oocytes or CHO K1 cells. Inactive S805A matriptase had no effect on either the current or the cleavage of ASIC1. The effect of matriptase on ASIC1 was specific, because it did not affect the function of ASIC2 and no matriptase-specific ASIC2 fragments were detected in oocytes or in CHO cells. Three matriptase recognition sites were identified in ASIC1 (Arg-145, Lys-185, and Lys-384). Site-directed mutagenesis of these sites prevented matriptase cleavage of ASIC1. Our results show that matriptase is expressed in glioma cells and that matriptase specifically cleaves ASIC1 in heterologous expression systems.
SUR LA RÉGULATION IONIQUE DU MILIEU INTÉRIEUR DE NEREIS DIVERSICOLOR O.F. MÜLLER
Creators: name: DE LEERSNYDER, Monique
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1971

description: Freezing-point, concentrations in Cl-, SO*—, Na+, K+, Ca++ and Mg++ electrolytes are determined on coelomic fluid of Nereis diversicolor O F. Müller placed in four different salinities. Osmotic regulation and ionic regulation are at work together inthecoelomic fluid of Nereis diversicolor. Ionic regulation is effective for all the ions.
(4001) Catherine Banks
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A cluster-based mean-field and perturbative description of strongly correlated fermion systems. Application to the 1D and 2D Hubbard model
Creators: name: Jiménez-Hoyos, Carlos A.
name: Scuseria, Gustavo E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We introduce a mean-field and perturbative approach, based on clusters, to describe the ground state of fermionic strongly-correlated systems. In cluster mean-field, the ground state wavefunction is written as a simple tensor product over optimized cluster states. The optimization of the single-particle basis where the cluster mean-field is expressed is crucial in order to obtain high-quality results. The mean-field nature of the ansatz allows us to formulate a perturbative approach to account for inter-cluster correlations; other traditional many-body strategies can be easily devised in terms of the cluster states. We present benchmark calculations on the half-filled 1D and (square) 2D Hubbard model, as well as the lightly-doped regime in 2D, using cluster mean-field and second-order perturbation theory. Our results indicate that, with sufficiently large clusters or to second-order in perturbation theory, a cluster-based approach can provide an accurate description of the Hubbard model in the considered regimes. Several avenues to improve upon the results presented in this work are discussed.
description: 22 pages, 21 figures
Rad18-mediated Translesion Synthesis of Bulky DNA Adducts Is Coupled to Activation of the Fanconi Anemia DNA Repair Pathway
Creators: name: Gurkar, Aditi
name: Song, Ihn Young
name: Palle, Komaraiah
name: Tateishi, Satoshi
name: Kupfer, Gary M.
name: Vaziri, Cyrus
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Fanconi anemia (FA) is a cancer susceptibility syndrome characterized by sensitivity to DNA-damaging agents. The FA proteins (FANCs) are implicated in DNA repair, although the precise mechanisms by which FANCs process DNA lesions are not fully understood. An epistatic relationship between the FA pathway and translesion synthesis (TLS, a post-replication DNA repair mechanism) has been suggested, but the basis for cross-talk between the FA and TLS pathways is poorly understood. We show here that ectopic overexpression of the E3 ubiquitin ligase Rad18 (a central regulator of TLS) induces DNA damage-independent mono-ubiquitination of proliferating cell nuclear antigen (PCNA) (a known Rad18 substrate) and FANCD2. Conversely, DNA damage-induced mono-ubiquitination of both PCNA and FANCD2 is attenuated in Rad18-deficient cells, demonstrating that Rad18 contributes to activation of the FA pathway. WT Rad18 but not an E3 ubiquitin ligase-deficient Rad18 C28F mutant fully complements both PCNA ubiquitination and FANCD2 activation in Rad18-depleted cells. Rad18-induced mono-ubiquitination of FANCD2 is not observed in FA core complex-deficient cells, demonstrating that Rad18 E3 ligase activity alone is insufficient for FANCD2 ubiquitylation. Instead, Rad18 promotes FA core complex-dependent FANCD2 ubiquitination in a manner that is secondary to PCNA mono-ubiquitination. Taken together, these results demonstrate a novel Rad18-dependent mechanism that couples activation of the FA pathway with TLS.
title: Midazolam for MRI? An evaluation of conscious sedation protocols in our department.
Creators: name: Tiong, Leonard
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Professional issues
subject: MR
subject: Audit and standards
subject: Sedation

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: MRI is a procedure in which some patients do not deal well with the length of scan or claustrophobic environment in which they are placed [1]. In our department, this has resulted in having a dedicated time slot reserved for those patients who will...
(4002) Janet McKenzie
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(4003) John Price
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Dorvilleidae (Polychaeta) from the Capbreton Canyon (Bay of Biscay, NE Atlantic) with the description of Pettiboneia sanmartini sp. nov.
Creators: name: AGUIRREZABALAGA, Florencio
name: CEBERIO, Argiloa
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2003

description: Three species of dorvilleid polychaetes are reported from bathyal depths of the Capbreton Canyon, Bay of Biscay.
 Pettiboneia sanmartini sp. nov. is described, Schistomeringos cf. anoculata is reported for the first time from the Eastern
 Atlantic and Protodorvillea kefersteini, reported for the first time from the bathyal étage.
Regulation of Human Cytidine Triphosphate Synthetase 2 by Phosphorylation
Creators: name: Hines, Maria
name: Graves, Lee M.
name: Higgins, Matthew J.
name: Kassel, Karen M.
name: Au, Da Ryung
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Cytidine triphosphate synthetase (CTPS) is the rate-limiting enzyme in de novo CTP synthesis and is required for the formation of RNA, DNA, and phospholipids. This study determined the kinetic properties of the individual human CTPS isozymes (hCTPS1 and hCTPS2) and regulation through substrate concentration, oligomerization, and phosphorylation. Kinetic analysis demonstrated that both hCTPS1 and hCTPS2 were maximally active at physiological concentrations of ATP, GTP, and glutamine, whereas the Km and IC50 values for the substrate UTP and the product CTP, respectively, were close to their physiological concentrations, indicating that the intracellular concentrations of UTP and CTP may precisely regulate hCTPS activity. Low serum treatment increased hCTPS2 phosphorylation, and five probable phosphorylation sites were identified in the hCTPS2 C-terminal domain. Metabolic labeling of hCTPS2 with [32P]H3PO4 demonstrated that Ser568 and Ser571 were two major phosphorylation sites, and additional studies demonstrated that Ser568 was phosphorylated by casein kinase 1 both in vitro and in vivo. Interestingly, mutation of Ser568 (S568A) but not Ser571 significantly increased hCTPS2 activity, demonstrating that Ser568 is a major inhibitory phosphorylation site. The S568A mutation had a greater effect on the glutamine than ammonia-dependent activity, indicating that phosphorylation of this site may influence the glutaminase domain of hCTPS2. Deletion of the C-terminal regulatory domain of hCTPS1 also greatly increased the Vmax of this enzyme. In summary, this is the first study to characterize the kinetic properties of hCTPS1 and hCTPS2 and to identify Ser568 as a major site of CTPS2 regulation by phosphorylation.
title: Detection of Pulmonary Nodules on Radiographs: ROC vs JAFROC Analyses of Radiologists Performance
Creators: name: Kohli, Akshay
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Thorax
subject: Lung
subject: Image manipulation / Reconstruction
subject: Digital radiography
subject: Plain radiographic studies
subject: Observer performance
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: • Lung cancer is the leading cause of cancer death worldwide and missing a nodule concerns every radiologist 1 . • Lung cancer was the 5th most commonly diagnosed cancer in Australia.In 2017, it is estimated that 12,434 new cases of lung cancer...
Attosecond photoionization dynamics with stimulated core-valence transitions
Creators: name: You, Jhih-An
name: Rohringer, Nina
name: Dahlström, Jan Marcus
Publisher: name: arXiv
Year: 2015
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We investigate ionization of neon atoms by an isolated attosecond pump pulse in the presence of two coherent extreme ultraviolet or x-ray probe fields. The probe fields are tuned to a core-valence transition in the residual ion and induce spectral shearing of the photoelectron distributions. We show that the photoelectron-ion coincidence signal contains an interference pattern that depends on the temporal structure of the attosecond pump pulse and the stimulated core-valence transition. Many-body perturbation theory is used to compute "atomic response times" for the processes and we find strikingly different behavior for stimulation to the outer-core hole (2p - 2s) and stimulation to the inner-core hole (2p - 1s). The response time of the inner-core transition is found to be comparable to that of state-of-the-art laser-based characterization techniques for attosecond pulses.
description: 12 pages, 5 figures
title: The Plu[e]cker letters fonds: 1824-1963
Creators: name: National Research Council Of Canada
Publisher: name: National Research Council of Canada
Year: 1963

description: The "The Plu[e]cker letters fonds: 1824-1963" collection is stored in the NRC Archives.
description: La collection "The Plu[e]cker letters fonds: 1824-1963" est conservée dans les Archives du CNRC.