cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 2 of Enhancing Mental and Physical Health of Women through Engagement and Retention (EMPOWER) 2.0 QUERI: study protocol for a cluster-randomized hybrid type 3 effectiveness-implementation trial
Creators: name: Hamilton, Alison B.
name: Finley, Erin P.
name: Bean-Mayberry, Bevanne
name: Lang, Ariel
name: Haskell, Sally G.
name: Moin, Tannaz
name: Farmer, Melissa M.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Mathematical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2. Sample Key Stakeholder Interview Guide.
APPLICATION OF TEMPERATURE-DEPENDENT THERMAL PROPERTIES IN FOOD THERMAL PROCESS SIMULATION AND SELECTION OF PRODUCT FORMULATION
Creators: name: Muniandy, Anbuhkani
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Food packaging, preservation and processing

description: Mathematical modeling of heat transfer is a common method utilized in designing thermal processes for food, modeling degradation kinetics of microorganisms and nutrients, designing food processing equipment as well as for process optimization and for ensuring scale-up feasibility of a product. It is essential to have all the necessary components for modeling including the geometry, boundary conditions, initial temperature, and the temperature-dependent thermal properties. Getting temperature-dependent thermal properties of food product is difficult due to the lack of effective and efficient devices or techniques. To show the influence of temperature-dependent thermal properties, retort processing of potato soup was simulated using both temperature-dependent (dynamic) and fixed thermal properties. Three methods, TPCell, Choi-Okos predictive model and KD2 Pro, were used to determine the thermal conductivity at 25°C and 120°C for comparison. The proximate composition of the sample was determined for prediction of thermal properties with the Choi-Okos model. The accuracy of simulation was evaluated based on the temperature at the cold spot and corresponding sterilization value. Results suggested that using temperature-dependent thermal properties in heat transfer modeling increased the accuracy of the simulation. Simulation performed with temperature-dependent properties obtained from TPCell matched very closely with experimental heat penetration data. Additionally, the sensitivity of temperature-dependent thermal properties obtained from TPCell in detecting variation in product formulation was evaluated. Four variations of potato soup were prepared to compare their respective lethality value. Thermal conductivity, specific heat capacity and density of the potato soups were measured, and simulation was performed using the measured thermal properties and a scheduled process as boundary conditions. Thermal properties of food product changed with the formulation which affected the processing time to achieve minimum lethality value. A significant difference in thermal conductivities was seen for these potato soups causing the scheduled process to be only suitable for thermal processing of some formulations while others would be undercooked that could lead to food safety risk. Since the thermal conductivity measurements were sensitive in detecting the difference in the formulation, it can be used as a tool to select a formulation that can best suit the processing conditions of the heat penetration tests. The technique described can be used for any thermal processes in the food industry including pasteurization, retort, and aseptic processing. This application will be beneficial for the industry to pre-screen the iterations and only select formulation that suits the scheduled process for successful heat penetration trials and reduce trial costs.
Fantasy and the Honour Code: Lope's "La viuda valenciana and "El cordobés valeroso Pedro Carbonero
Creators: name: Sawhney, Minni
Publisher: name: Humanities Commons
Year: 2011
Subjects: subject: Spanish drama
subject: Seventeenth century
subject: Vega, Lope de, 1562-1635
subject: Islam
subject: Inquisition

description: Portrayal of Otherness in Lope's dramas
Development of an immune-related prognostic biomarker for triple-negative breast cancer
Creators: name: Zhang, Yan
name: Wang, Quan
name: Yang, Wei-Kang
name: Wang, Yong-Si
name: Zhou, Qiao
name: Lin, Jie
name: Wei, Xu-Xuan
name: Liang, Tian
name: Liu, Tongtong
name: Fan, Wen-Tao
name: Liang, Li
name: Xu, You-Nian
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Purpose: Oncology studies employing digital dissection methodologies have provided some insight on the biological features of tumor microenvironment of Triple-negative breast cancer (TNBC), but molecular diagnostics rarely have therapeutic impact. We aimed to identify a novel prognostic biomarker to investigate immune characteristics of TNBC using transcriptomic features. Patients and Methods: We extracted whole transcriptome from breast cancer tissue of 30 TNBC patients and then used bioinformatics approaches to characterize the different immune cell contents in tumor tissue and para-cancerous tissue. We extract 2 indicators to describe the major differences in immune infiltration in the microenvironment between tumor tissue and para-cancerous tissue. We then combined the 2 indicators that represent the levels of increased and decreased infiltration in each sample to obtain the Immune Infiltration Score (IIS). Then we compared the tumor-infiltrating immune cell contents and immune infiltrating status in TNBC samples with CIBERSORT and ESTIMATE score to validate the IIS. Finally, 132 TNBC patients from the Cancer Genome Atlas program (TCGA) dataset was used to validate the predictive power of IIS. Results: 4 types of upregulated and 4 types of downregulated immune cells were identified in the tumor tissue samples of the TNBC patients. Then we developed a novel biomarker, IIS. Results showed that IIS score can clearly separate cancer and para-cancerous tissue. Using the same cutoff value of 0 in the TNBC-TCGA cohort, we show that those patients with a higher IIS had significantly higher PD-L1 expression and shorter progression-free survival time than those with a lower IIS value, indicating IIS score can be generalized to other TNBC datasets. Conclusion: we explored the immune infiltration landscape in 30 TNBC patients and provided IIS as a novel and reliable biomarker to evaluate the progression-free survival and prognosis of the TNBC patients.
Strukturen der Überwachung und des Managements von Infektionskrankheiten in der EU
Creators: name: Ammon, Andrea
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2005
Subjects: subject: ECDC
subject: Surveillance-Netzwerke
subject: Falldefinitionen
subject: EU
subject: Zoonosen-Richtlinie
subject: Case definitions
subject: Surveillance networks
subject: Zoonoses directive
subject: 610 Medizin

description: Im Jahr 1998 wurde von EU-Parlament und Ministerrat die Entscheidung zur Etablierung eines EU-weiten Netzwerks zur Überwachung von Infektionskrankheiten getroffen. Bei der Entwicklung dieses Netzwerks legten Netzwerk-Komitee (die Vertreter der Mitgliedsstaaten) und Kommission zunächst die in der Surveillance zu erfassenden Krankheiten fest. Als nächster Schritt wurden Falldefinitionen für die EU-weite Überwachung geschaffen. Zum schnellen Informationsaustausch über schwerwiegende Krankheiten, Ausbrüche und die im Zusammenhang damit getroffenen Maßnahmen gibt es ein Web-basiertes Frühwarnsystem mit Passwort-geschütztem Zugang. Parallel dazu etablierten sich zur vertieften Erfassung wichtiger Erkrankungen krankheitsspezifische Surveillance-Netzwerke, die unterschiedliche inhaltliche Schwerpunkte und Verfahrensweisen entwickelt haben. Ein Trainingsprogramm (EPIET) und das europäische Bulletin Eurosurveillance bilden krankheitsübergreifende Aspekte des Netzwerks. Im Rahmen der EU-Richtlinie zum Monitoring von Zoonosen werden Daten zu bestimmten zoonotischen Infektionskrankheiten aus dem Human-, Veterinär- und Lebensmittelbereich auf EU-Ebene zusammenfassend bewertet. Im Mai 2005 ist die Koordination und Weiterentwicklung des Netzwerks auf das Europäische Zentrum für die Prävention und die Kontrolle von Krankheiten (ECDC) übergegangen.
description: In 1998, the European Parliament and Council published the Decision on setting up a network for the epidemiological surveillance of communicable diseases in the Community. As a first step, the Network Committee (representatives of the Member States) and the Commission determined the diseases for European surveillance. Subsequently, case definitions were developed for these diseases. For rapid information exchange among Member States on serious diseases, outbreaks and the control measures taken, a web-based, password protected early warning system was established. In parallel disease-specific networks were developed for enhanced surveillance of important diseases. A training programme (EPIET) and a European bulletin (Eurosurveillance) complete the network. The directive on the monitoring of zoonoses constitutes the basis for the joint analysis and evaluation of data on human illnesses, animals and foods. Starting in May 2005, the coordination and further development of the Community Network will be carried out by the European Centre for Disease Prevention and Control (ECDC).
Un nuevo espacio en la literatura mexicana: La obra fronteriza de luís Humberto Crosthwaite y Gabriel Trujillo Muñoz
Creators: name: Sawhney, Minni
Publisher: name: Casa de los poetas editores
Year: 2012
Subjects: subject: Borderlands
subject: Frontier and pioneer life--Study and teaching

description: La literatura de la frontera norte
Additional file 1 of Structured interviews on self-regulated learning strategies of medical students in the final year of medical school
Creators: name: Corazza, Laura
name: Shirkhani, Sepide
name: Berberat, Pascal O
name: Wijnen-Meijer, Marjo
Publisher: name: figshare
Year: 2024
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 1
Person-centred care in individuals with stroke: a qualitative study using in-depth interviews
Creators: name: Martín-Sanz, María Belén
name: Salazar-de-la-Guerra, Rosa María
name: Cuenca-Zaldivar, Juan Nicolas
name: Salcedo-Perez-Juana, María
name: Garcia-Bravo, Cristina
name: Palacios-Ceña, Domingo
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Environmental Sciences not elsewhere classified
subject: Science Policy
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: Person-centred care (PCC) has considerable effects on the clinical practice of health professionals. The purpose of this study was to describe the perspectives and perceived barriers and enablers of individuals with stroke regarding the PCC model in stroke rehabilitation. A qualitative exploratory study was conducted based on an interpretive framework. Participants were recruited using non-probabilistic purposeful sampling and a snowball-technique strategy. The inclusion criteria consisted of: (a) individuals > 18 years, (b) diagnosed with moderate or severe stroke according to the National Institutes of Health Stroke Scale and (c) in the post-acute or chronic stage of the disease. In total, 31 individuals with stroke were included. In-depth interviews and researchers’ field notes were used to collect the data. A thematic analysis was performed. Also, credibility, transferability, dependability and confirmability techniques were followed to establish trustworthiness of the data. Thirty-one individuals with stroke (11 women) were included. Three main themes were identified: (a) The person behind the “patient” label, recognizing the person beyond their illness and valuing their identity and individual characteristics, (b) The person at the centre of care, considering themselves as an active agent in their own care and respecting their preferences and expectations for their care process and (c) Training for PCC, providing health professionals with tools to achieve professional skills for the implementation and development of the PCC model. This paper describes relevant aspects that health professionals should consider when providing PCC in the context of the rehabilitation of individuals with stroke.
Key messagesThe individuals’ perspective regarding person-centred care (PCC) has considerable effects on the clinical practice of health professionals.Individuals with stroke describe how there is a person behind the "patient" label, with identity, needs and desire to participate in decision making.Training in the PCC model helps healthcare professionals identify the needs of individuals with stroke during rehabilitation. The individuals’ perspective regarding person-centred care (PCC) has considerable effects on the clinical practice of health professionals. Individuals with stroke describe how there is a person behind the "patient" label, with identity, needs and desire to participate in decision making. Training in the PCC model helps healthcare professionals identify the needs of individuals with stroke during rehabilitation.
Miguel Hernández: convergencias simbólicas de una cosmovisión que actúa incesante sobre el mundo
Creators: name: Berroa, Rei
Publisher: name: Humanities Commons
Year: 2015

description: The two main symbols of Miguel Hernández’s work are the bull and the womb. The first appears in the initial stages of his brief but intense literary activity, while the second is linked to his experience as husband, father, and soldier. Both symbols merge and explain each other in the plurivalent triptych: life, love, and death. The bull represents the search for the experience of love and the struggles the lyric subject has to endure in order to attain it, while the womb, cosmic center of the gestation of life, coincides with the circumstance of paternity that the poet pursued since his wedding. Denied the latter by life (he was a father but could not perform as a father), his poetry is the epitome, still unmatched, of a much wider paternity: that of the poet-father of the Earth’s poetry.  Los dos símbolos centrales de la obra de Miguel Hernández son el toro y el vientre. El primero se manifi esta en la fase inicial de su breve e intensa vida literaria, mientras que el segundo está ligado a su etapa de esposo, padre y soldado. Ambos símbolos confl uyen y se explican en el plurivalente tríptico: vida, amor y muerte. El toro representa la búsqueda de la experiencia del amor y las luchas a las que se enfrenta el sujeto lírico para lograrlo, mientras el vientre, centro cósmico de la gestación de la vida, coincide con la circunstancia de la paternidad que el poeta persiguió desde su casamiento. Negada ésta por la vida (fue padre sin poder hacer de padre), su poesía es el eje, aún no repetido, de una paternidad aún más amplia: la del poeta-padre de la poesía de la Tierra.
Additional file 3 of Enhancing Mental and Physical Health of Women through Engagement and Retention (EMPOWER) 2.0 QUERI: study protocol for a cluster-randomized hybrid type 3 effectiveness-implementation trial
Creators: name: Hamilton, Alison B.
name: Finley, Erin P.
name: Bean-Mayberry, Bevanne
name: Lang, Ariel
name: Haskell, Sally G.
name: Moin, Tannaz
name: Farmer, Melissa M.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Mathematical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 3. EMPOWER 2.0 Periodic Reflections Template.
Real-time cytotoxicity assay for rapid and sensitive detection of ricin from complex matrices.
Creators: name: Pauly, Diana
name: Worbs, Sylvia
name: Kirchner, Sebastian
name: Shatohina, Olena
name: Dorner, Martin
name: Dorner, Brigitte
Publisher: name: Robert Koch-Institut, Biologische Sicherheit
Year: 2012
Subjects: subject: Animals
subject: Cercopithecus aethiops
subject: Sensitivity and Specificity
subject: Biological Assay/methods
subject: Ricin/analysis
subject: Toxicity Tests/methods
subject: Toxins Biological/analysis
subject: Vero Cells
subject: 610 Medizin

description: Background: In the context of a potential bioterrorist attack sensitive and fast detection of functionally active toxins such as ricin from complex matrices is necessary to be able to start timely countermeasures. One of the functional detection methods currently available for ricin is the endpoint cytotoxicity assay, which suffers from a number of technical deficits. Methodology/Findings: This work describes a novel online cytotoxicity assay for the detection of active ricin and Ricinus communis agglutinin, that is based on a real-time cell electronic sensing system and impedance measurement. Characteristic growth parameters of Vero cells were monitored online and used as standardized viability control. Upon incubation with toxin the cell status and the cytotoxic effect were visualized using a characteristic cell index–time profile. For ricin, tested in concentrations of 0.06 ng/mL or above, a concentration-dependent decrease of cell index correlating with cytotoxicity was recorded between 3.5 h and 60 h. For ricin, sensitive detection was determined after 24 h, with an IC50 of 0.4 ng/mL (for agglutinin, an IC50 of 30 ng/mL was observed). Using functionally blocking antibodies, the specificity for ricin and agglutinin was shown. For detection from complex matrices, ricin was spiked into several food matrices, and an IC50 ranging from 5.6 to 200 ng/mL was observed. Additionally, the assay proved to be useful in detecting active ricin in environmental sample materials, as shown for organic fertilizer containing R. communis material. Conclusions/Significance: The cell-electrode impedance measurement provides a sensitive online detection method for biologically active cytotoxins such as ricin. As the cell status is monitored online, the assay can be standardized more efficiently than previous approaches based on endpoint measurement. More importantly, the real-time cytotoxicity assay provides a fast and easy tool to detect active ricin in complex sample matrices.
Additional file 1 of Antimicrobial resistance markers distribution in Staphylococcus aureus from Nsukka, Nigeria
Creators: name: Agbo, Martina C.
name: Ezeonu, Ifeoma M.
name: Onodagu, Beatrice O.
name: Ezeh, Chukwuemeka C.
name: Ozioko, Chizoba A.
name: Emencheta, Stephen C.
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Supplementary Material 1
On Being One's Own Heir: British Portraiture, Metaphysical Inheritance,  and The Picture of Dorian Gray
Creators: name: Christensen, Andrew
Publisher: name: Humanities Commons
Year: 2019
Subjects: subject: Nineteenth century
subject: English literature
subject: British literature
subject: Art
subject: History
subject: Irish literature

description: Much scholarship on The Picture of Dorian Gray has focused on its possible textual sources and its place in literary traditions. This article demonstrates that by contextualizing the novel in the history of art and the tradition of British portraiture, we are able to answer significant yet overlooked questions such as why Wilde chose “picture” rather than “portrait” for his title and are better prepared to appreciate the serious themes underlying the fantastical tale. The magical portrait of Dorian is most readily identifiable as a literary gothic motif, yet, in developing his central plot device, Wilde also draws on metaphysical and mystical theories of portraiture current in the British tradition and from throughout the history of art. These, in turn, are rooted in wide-ranging superstitions and other cultural attitudes toward imagery that have proven both influential and enduring. The philosophical symbolism of Wilde’s portrait contributes to a narrative of metaphysical inheritance and an allegory of arrested development through which Wilde is also able to test certain aesthetic doctrines which, however cherished, are seen to fail in Dorian’s case.
History matching of surfactant-polymer flooding
Creators: name: Naik, Pratik Kiranrao
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Mechanical engineering not elsewhere classified

description: This thesis presents a framework for history matching and model calibration of surfactant-polymer (SP) flooding. At first, a high-fidelity mechanistic SP flood model is constructed by performing extensive lab-scale experiments on Berea cores. Then, incorporating Sobol based sensitivity analysis, polynomial chaos expansion based surrogate modelling (PCE-proxy) and Genetic algorithm based inverse optimization, an optimized model parameter set is determined by minimizing the miss-fit between PCE-proxy response and experimental observations for quantities of interests such as cumulative oil recovery and pressure profile. The epistemic uncertainty in PCE-proxy is quantified using a Gaussian regression process called Kriging. The framework is then extended to Bayesian calibration where the posterior of model parameters is inferred by directly sampling from it using Markov chain Monte Carlo (MCMC). Finally, a stochastic multi-objective optimization problem is posed under uncertainties in model parameters and oil price which is solved using a variant of Bayesian global optimization routine.
Everybody
Creators: name: E. Tavares, Elizabeth
Publisher: name: Humanities Commons
Year: 2019
Subjects: subject: Drama, Medieval
subject: England
subject: Middle Ages

description: How does one make a medieval English morality play relevant for 2018? By thematizing one of the oldest devices of actorly virtuosity, doubling, Branden Jacobs-Jenkins’s Pulitzer-nominated Everybody has found a way to access contemporary ideas about death in exploring the intersection with the identity politics of race. Advertising materials for the ninety-minute play promoted not its heritage, but the fact that every performance would be highly unique due to an embedded lottery device. As the Usher (Sarah Lucht) explained at the top of the show while doling out bingo balls from a cage, this was done in order to “thematize the randomness of death while also destabilizing your [the audience’s] preconceived notions about identity.”
Projection of global burden and risk factors for aortic aneurysm – timely warning for greater emphasis on managing blood pressure
Creators: name: Huang, Xuewei
name: Wang, Zhouxiang
name: Shen, Zhengjun
name: Lei, Fang
name: Liu, Ye-Mao
name: Chen, Ze
name: Qin, Juan-Juan
name: Liu, Hui
name: Ji, Yan-Xiao
name: Zhang, Peng
name: Zhang, Xiao-Jing
name: Yang, Juan
name: Cai, Jingjing
name: She, Zhi-Gang
name: Li, Hongliang
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Medicine
Cell Biology
Biotechnology
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Cancer
Science Policy

description: Aortic aneurysm (AA) is a serious condition that largely increases the risk of aortic dissection and sudden death. Exploring the global burden of disease and changes in risk factors for AA is essential for public health policy development. To project the death burden from AA and its attributable risk factors in the following decade based on the epidemiological data over the past 30 years. We analysed the death burden of AA and trends of four risk factors from 1990–2019 using the updated 2019 Global Burden of Disease study database by Joinpoint regression analysis. Furthermore, we project the AA-related death burden for the next decade using the Bayesian age-period-cohort model. This study discovered that the global burden of death attributable to AA began to increase after decreasing for two decades. This upward trend will continue in the subsequent decade (average annual percent change: 0.318%, 95% CI: 0.288 to 0.348). Meanwhile, the disease burdens in all economic regions except high-middle socio-demographic index (SDI) regions will continuously increase in the next decade, with the fastest acceleration in the low-middle SDI region (average annual percent change: 1.183%, 95% CI: 1.166 to 1.200). Notably, high systolic blood pressure will surpass the contribution of smoking to become the most important risk factor for mortality due to AA. This study discovered a rebounding trend in the aortic aneurysm-related death burden globally. High systolic blood pressure will be the top risk factor attributed to death from AA. Therefore, it should be considered as the first-degree risk factor in the guidance of AA management and criteria for population-based screening programs.Key messagesThe death burden of aortic aneurysms is beginning to rebound globally, and the trend will continue for the next decade.High systolic blood pressure will replace smoking as the most important risk factor associated with aortic aneurysm death. The death burden of aortic aneurysms is beginning to rebound globally, and the trend will continue for the next decade. High systolic blood pressure will replace smoking as the most important risk factor associated with aortic aneurysm death.
Navigation Based Path Planning by Optimal Control Theory
Creators: name: Nolan, Sean M.
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Aerospace engineering not elsewhere classified

description: Previous studies have shown that implementing trajectory optimization can reduce state estimations errors. These navigation based path planning problems are often diffcult to solve being computationally burdensome and exhibiting other numerical issues, so former studies have often used lower- delity methods or lacked explanatory power.
This work utilizes indirect optimization methods, particularly optimal control theory, to obtain high-quality solutions minimizing state estimation errors approximated by a continuous-time extended Kalman lter. Indirect methods are well-suited to this because necessary conditions of optimality are found prior to discretization and numerical computation. They are also highly parallelizable enabling application to increasingly larger problems.
A simple one dimensional problem shows some potential obstacles to solving problems of this type including regions of the trajectory where the control is unimportant. Indirect trajectory optimization is applied to a more complex scenario to minimize location estimation errors of a single cart traveling in a 2-D plane to a goal location and measuring range from a xed beacon. This resulted in a 96% reduction of the location error variance when compared to the minimum time solution. The single cart problem also highlights the importance of the matrix that encodes the linearization of the vehicle's measurement with respect to state. It is shown in this case that the vehicle roughly attempts to maximize the magnitude of its elements. Additionally, the cart problem further illustrates problematic regions of a design space where the objective is not signi cantly affected by the trajectory.
An aircraft descent problem demonstrates the applicability of these methods to aerospace problems. In this case, estimation error variance is reduced 28.6% relative to the maximum terminal energy trajectory. Results are shown from two formulations of this problem, one with control constraints and one with control energy cost, to show the bene ts and disadvantages of the two methods. Furthermore, the ability to perform trade studies on vehicle and trajectory parameters is shown with this problem by solving for di erent terminal velocities and different initial locations.
Additional file 1 of The good, the bad, and the blameless in parenting: a thematic analysis of discussions of childhood obesity on an internet forum
Creators: name: Koivumäki, Terhi
name: Jallinoja, Piia
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 1. Attachment 1. The list of discussion threads included in the data and number of parents (n = 56), their posts (n = 88), and commenters’ posts (n = 243) in the threads.
Additional file 2 of Effective contribution ratio of the molar during sequential distalization using clear aligners and micro-implant anchorage: a finite element study
Creators: name: Liu, Xulin
name: Wu, Junjie
name: Cheng, Yuxun
name: Gao, Jie
name: Wen, Yi
name: Zhang, Yubohan
name: Luo, Houzhuo
name: Jin, Zuolin
name: Ma, Yanning
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology

description: Additional file 2. Three-dimensional displacement values for the anterior teeth (mm).
Surveillance of tularaemia in Kosovo*, 2001 to 2010
Creators: name: Grunow, Roland
name: Kalaveshi, A.
name: Kühn, Andrea
name: Mulliqi-Osmani, G.
name: Ramadani, N.
Publisher: name: Robert Koch-Institut, Biologische Sicherheit
Year: 2012
Subjects: subject: Adolescent
subject: Humans
subject: Disease Outbreaks
subject: Middle Aged
subject: Incidence
subject: Population Surveillance
subject: Child
subject: Adult
subject: Aged
subject: Infant
subject: Age Distribution
subject: Enzyme-Linked Immunosorbent Assay
subject: Young Adult
subject: Child Preschool
subject: Sex Distribution
subject: Aged 80 and over
subject: Infant Newborn
subject: Blotting Western
subject: Follow-Up Studies
subject: Drinking Water/microbiology
subject: Francisella tularensis/isolation & purification
subject: Tularemia/diagnosis
subject: Tularemia/epidemiology
subject: Tularemia/microbiology
subject: Yugoslavia/epidemiology
subject: 610 Medizin

description: Tularaemia, caused by Francisella tularensis, had not been registered in Kosovo* before an outbreak in 1999 and 2000. A national surveillance system has been implemented in Kosovo* since 2000 to monitor a number of diseases, including tularaemia. Antibody detection in human sera was used for laboratory diagnosis of tularaemia and F. tularensis lipopolysaccharide antigen was used as a marker of infection. The purpose of this study is to describe the incidence of tularaemia in Kosovo* after the 1999–00 outbreak. In 2001 and 2002, a second outbreak occurred, with 327 serologically confirmed cases. From 2001 to 2010, 25–327 cases were registered per year, giving a mean annual incidence of 5.2 per 100,000 population. The most likely sources of infection were contaminated drinking water and food. The dominant clinical manifestations were the glandular (79%) and ulcero-glandular (21%) forms. By 2010, the disease had spread throughout Kosovo*. Presumably as a result of war and subsequent environmental disruption, mass population displacement and breakdown of sanitation and hygiene, the two major outbreaks of tularaemia resulted in the establishment of an active endemic area of tularaemia in Kosovo*.
RNA helicase retinoic acid-inducible gene I as a sensor of Hantaan virus replication
Creators: name: Lee, Min-Hi
name: Lalwani, Pritesh
name: Raftery, Martin J.
name: Matthaei, Markus
name: Lütteke, Nina
name: Kirsanovs, Sina
name: Binder, Marco
name: Ulrich, Rainer G.
name: Giese, Thomas
name: Wolff, Thorsten
name: Krüger, Detlev H.
name: Schönrich, Günther
Publisher: name: Robert Koch-Institut
Year: 2011
Subjects: subject: Cell Line
subject: Humans
subject: Virus Replication
subject: Host-Pathogen Interactions
subject: DEAD-box RNA Helicases/immunology
subject: DEAD-box RNA Helicases/metabolism
subject: Gene Knockdown Techniques
subject: Hantaan virus/immunology
subject: Hantaan virus/physiology*
subject: 610 Medizin

description: Hantaan virus (HTNV) causes severe human disease. The HTNV genome consists of three ssRNA segments of negative polarity that are complexed with viral nucleocapsid (N) protein. How the human innate immune system detects HTNV is unclear. RNA helicase retinoic acid-inducible gene I (RIG-I) does not sense genomic HTNV RNA. So far it has not been analysed whether pathogen-associated molecular patterns generated during the HTNV replication trigger RIG-I-mediated innate responses. Indeed, we found that knock-down of RIG-I in A549 cells, an alveolar epithelial cell line, increases HTNV replication and prevents induction of 2',5'-oligoadenylate synthetase, an interferon-stimulated gene. Moreover, overexpression of wild-type or constitutive active RIG-I in Huh7.5 cells lacking a functional RIG-I diminished HTNV virion production. Intriguingly, reporter assays revealed that in vitro-transcribed HTNV N RNA and expression of the HTNV N ORF triggers RIG-I signalling. This effect was completely blocked by the RNA-binding domain of vaccinia virus E3 protein, suggesting that dsRNA-like secondary structures of HTNV N RNA stimulate RIG-I. Finally, transfection of HTNV N RNA into A549 cells resulted in a 2 log-reduction of viral titres upon challenge with virus. Our study is the first demonstration that RIG-I mediates antiviral innate responses induced by HTNV N RNA during HTNV replication and interferes with HTNV growth.
Optimisation of expression and purification of the feline and primate foamy virus transmembrane envelope proteins using a 96 deep well screen
Creators: name: Mühle, Michael
name: Löchelt, Martin
name: Denner, Joachim
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2011
Subjects: subject: Transmembrane envelope protein
subject: Optimisation of protein expression
subject: High throughput screening
subject: Foamy viruses
subject: HIV-1
subject: 610 Medizin

description: The production of recombinant transmembrane proteins is due to their biochemical properties often troublesome and time consuming. Here the prokaryotic expression and purification of the transmembrane envelope proteins of the feline and primate foamy viruses using a screening assay for optimisation of expression in 96 deep well plates is described. Testing simultaneously various bacterial strains, media, temperatures, inducer concentrations and different transformants, conditions for an about twentyfold increased production were quickly determined. These small scale test conditions could be easily scaled up, allowing purification of milligram amounts of recombinant protein. Proteins with a purity of about 95% were produced using a new purification protocol, they were characterised by gel filtration and circular dichroism and successfully applied in immunological assays screening for foamy virus infection and in immunisation studies. Compared to the previously described protocol (M. Mühle, A. Bleiholder, S. Kolb, J. Hübner, M. Löchelt, J. Denner, Immunological properties of the transmembrane envelope protein of the feline foamy virus and its use for serological screening, Virology 412 (2011) 333–340), proteins with similar characteristics but about thirtyfold increased yields were obtained. The screening and production method presented here can also be applied for the production of transmembrane envelope proteins of other retroviruses, including HIV-1.
DEVELOPMENT OF A SWIRL-STABILIZED PLASMA-ASSISTED BURNER WITH A RING-PIN ELECTRODE CONFIGURATION
Creators: name: Numa, Nadia M.
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Aerospace engineering not elsewhere classified

description: A small plasma generation system was first developed using a ring-pin electrode configuration with the goal of producing a plasma disk at the burner outlet. Two distinct plasma regimes were identified: diffused and filamentary. Diffuse discharges were generated at low frequencies while filamentary discharges were generated at moderate to high frequencies. The induced flow fields generated by both diffuse and filamentary plasma discharges were investigated using high-speed schlieren visualization and particle image velocimetry. The rise in gas temperature was measured using optical emission spectroscopy. Lastly, the electrical properties for both types of plasma discharges was measured. The measurements provided a set of pulse parameters for the investigation of the plasma-flame interaction on the atmospheric pressure burner. An atmospheric pressure plasma-assisted burner with a ring-pin electrode geometry was designed and fabricated to investigate the effect of nanosecond repetitively pulsed discharges on methane-air flames. The burner can produce both Bunsen-type and swirl-stabilized flames (helical vane swirlers, swirl number of 0.62) with a modular design to allow for a removable block swirler component. Flame chemiluminescence and direct imaging of flame structure and dynamics was done to understand the burner’s operating limits. The burner can operate 6 – 13 kW flames, with flames stabilizing at approximately 2 inches above the burner exit. The effect of air flow rate on plasma formation was investigated and it was found that the high velocity of the incoming gas changes the plasma regime and electrical properties. Finally, the plasma discharge was applied on lifted, swirled flames and used for plasma-assisted ignition. For lifted swirled flames, we found that a minimum of 100 pulses is required to generate a filamentary discharge in the air stream. Higher number of pulses at high frequencies appeared to extinguish the primary flame. A minimum of 6000 was used for ignition. The plasma-assisted burner will allow for future studies to investigate the plasma flame coupling for various conditions using a wide variety of diagnostics.
UNRAVELING INSTABILITY: THE POLITICS BEHIND COUPS IN FRANCOPHONE AFRICA
Creators: name: João, Carlos Pereira dos Santos
name: Ana, Luiza Oliveira Almeida
Publisher: name: AYDEN JOURNAL
Year: 2025
Subjects: Francophone Africa, coups d'état, political unrest, democratic progress, socio-political dynamics

description: In recent years, Francophone Africa has experienced a surge in political unrest characterized by a series of coups d'état, disrupting the democratic progress achieved since the 1990s. This article delves into the underlying causes, implications, and international responses to these coups, particularly focusing on notable occurrences in Mali, Burkina Faso, and Niger. By employing a multidimensional analysis, encompassing political, economic, and social dynamics, the article aims to unravel the intricate factors that precipitated these coups. Understanding these complexities is imperative for devising effective strategies to address and mitigate the recurrence of such destabilizing events. Through a comprehensive examination of the region's socio-political landscape, this study endeavors to provide insights into the root causes of political upheaval, offering avenues for fostering stability and democratic resilience
Contingency, Staff, Anxious Pedagogy — and Love
Creators: name: Skallerup Bessette, Lee
Publisher: name: Humanities Commons
Year: 2019
Subjects: subject: Teaching
subject: Critical pedagogy
subject: Graduate students--Employment
subject: Career changes
subject: Affect (Psychology)
subject: Casual labor

description: This essay explores the role of love, as defined by bell hooks, in pedagogy as well as how it plays into anxiety in our current moment.
If Ophelia were Macro, not Micro
Creators: name: Iyengar, Sujata
Publisher: name: Humanities Commons
Year: 2011
Subjects: subject: Shakespeare, William, 1564-1616
subject: Popular culture
subject: Art
subject: History

description: Because of a series of miscommunications, I originally wrote a 6000-word essay for the Cambridge Guide to the Worlds of Shakespeare on Ophelia and Popular Culture rather than the 1500 words that it turned out they wanted. Bruce R. Smith graciously let me go up to 3000 words, and I republished some of my research in other articles, but some of this material never did find another home. In this version I schematize the history of Ophelia in popular culture in four categories: the "folk" Ophelia, the "pop" Ophelia, the "public" Ophelia, and the "global" Ophelia.
In-vivo Tracing of Vagal Projections in the Brain with Manganese Enhanced Magnetic Resonance Imaging
Creators: name: Oleson, Steven T.
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Biomechanical engineering

description: Current challenges in neuronal tract tracing include sacrificing the animal, detailed sectioning of the brain, and cumbersome reconstruction of slices to gather information, which are very tedious, time consuming, and have low-throughput. In this regard, Manganese-enhanced Magnetic Resonance Imaging (MEMRI) has been an emerging methodology for fiber tract tracing in vivo. The manganese ion (Mn2+) is paramagnetic and is analogous to calcium ions (Ca2+), which allows it to enter excitable cells through voltage-gated calcium channels, thereby reporting cellular activity in T1-weighted MR images. Moreover, once the Mn2+enters the cell, it will move along the axon by microtubules, release at the synapse, and then uptake by post-synaptic neurons, hence revealing the pathway of Mn2+ transportation. While most MEMRI neuronal tracing studies have focused on mapping circuitries within the brain, MEMRI has rarely been applied to trace peripheral nerve projections into the brain. In this thesis, I will propose the use of MEMRI to trace vagal nerve projections into the central nervous system by showing enhancement of neuronal pathways with an optimized protocol. This protocol demonstrates in vivo monitoring of manganese transport into the brain from the nodose ganglion and shows how the enhancement in MR images can be promoted with vagus nerve stimulation (VNS). Additionally, I will present preliminary findings, for the very first time, that show the downstream projection of the sympathetic pathway from the brainstem. In sum, the technique presented in this thesis will shed light on the use of MEMRI to study the functional results of using clinically-based VNS settings
Strangeness: Early Modern European Women and the Invention of Whiteness
Creators: name: Iyengar, Sujata
name: Iyengar, Sujata
name: Iyengar, Sujata
Publisher: name: Humanities Commons
Year: 2017
Subjects: subject: Europe
subject: History
subject: Drama
subject: Sixteenth century
subject: Seventeenth century
subject: Women
subject: Race
subject: Ethnicity
subject: Nationalism
subject: Feminism

description: The Afterword to this EMLS Special Issue “European Women in Early Modern English Drama" contextualizes this collection in light of our continued scholarly and social investigation into the invention of "whiteness" and of a pan-European identity. It argues that texturing the flat surface of "whiteness" and "Europeanness" can enable us to "estrange" -- that is, to critique and de-nature, existing stereotypes surrounding race, sexuality, and national origin. It concludes with a call to further research and writing about the material or phenomenological textures of individual women's lives, as we can imagine them through literature and history.
Infektionsepidemiologische Daten von Blutspendern 2005
Creators: name: Offergeld, Ruth
name: Ritter, Sabine
name: Hamouda, Osamah
Publisher: name: Robert Koch-Institut
Year: 2007
Subjects: subject: HIV
subject: Hepatitis C
subject: Blutspender
subject: Hepatitis B
subject: Infektionsmeldungen
subject: blood donor
subject: transfusion-relevant infections
subject: 610 Medizin

description: Die Erhebung infektionsepidemiologischer Daten zur Bestimmung der Prävalenz und Inzidenz von HIV-, Hepatitis-C-Virus-(HCV-), Hepatitis-B-Virus-(HBV-) und Syphilisinfektionen im Blut- und Plasmaspendewesen in Deutschland wird auf der Grundlage des § 22 Transfusionsgesetz vom Robert Koch-Institut durchgeführt. Die vierteljährlich erhobenen Daten erlauben eine Aussage über die Infektionshäufigkeit in den Spenderkollektiven und somit indirekt eine Beurteilung der Sicherheit der gewonnenen Spenden. Der vorliegende Bericht erstreckt sich auf das Jahr 2005 und beinhaltet die Daten aller Blutspendeeinrichtungen in Deutschland. Die Gesamtzahl infektionsserologischer Untersuchungen von Blutspenden und Voruntersuchungen von Spendewilligen betrug 6,26 Millionen. Die Prävalenz, bezogen auf 100.000 Spenden, lag für HIV bei 6,1, für HCV bei 81,2, für HBV bei 143,9 und für Syphilis bei 35,6. Der Anteil der Serokonversionen, bezogen auf 100.000 Spenden, lag für HIV bei 0,9, für HCV bei 1,4, für HBV bei 0,9 und für Syphilisinfektionen bei 2,3. Die Auswertung zeigt, bei insgesamt sehr niedrigen Infektionshäufigkeiten, weiterhin rückläufige HCV-Infektionszahlen unter Neuspendern und einen Anstieg der HIV- und Syphilis-Neuinfektionen seit 1999. Mögliche Ursachen für Letzteren müssen weiter untersucht werden.
description: The Robert Koch Institute collects and evaluates data on the prevalence and incidence of HIV, hepatitis C (HCV), hepatitis B (HBV) and syphilis infections among blood and plasma donors in Germany according to article 22 of the Transfusion Act. The surveillance data permit an assessment of the occurrence of infections in the blood donor population and consequently the safety of the collected donations. This report includes data from all blood donation services in Germany for 2005. In total, 6.26 million donations or blood samples from prospective donors were screened. The prevalence of the relevant infections was 6.1/100,000 for HIV, 81.2/100,000 for HCV, 143.9/100,000 for HBV and 35.6/100,000 donations for syphilis. The rate of seroconversions/100,000 donations was 0.9 for HIV, 1.4 for HCV, 0.9 for HBV and 2.3 for syphilis. The analysis showed a very low incidence of infections with a decreasing trend for HCV infections among first time donors and an increase in incident HIV and syphilis infections since 1999. The latter has to be monitored carefully and possible causes need to be evaluated.