cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The German Environmental Survey for Children (GerES IV): Reference values and distributions for time-location patterns of German children
Creators: name: Conrad, André
name: Seiwert, Margarete
name: Hünken, Andreas
name: Quarcoo, David
name: Schlaud, Martin
name: Groneberg, David
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2012
Subjects: subject: Children
subject: Time-location patterns
subject: Reference values
subject: Reference distributions
subject: Exposure assessment
subject: Body weight
subject: Physical activity
subject: 610 Medizin

description: Children's time-location patterns are important determinants of environmental exposure and other health-relevant factors. Building on data of the German Environmental Survey for Children (GerES IV), our study aimed at deriving reference values and distributions for time-location patterns of 3–14-year-old German children. We also investigated if GerES IV data are appropriate for evaluating associations with children's health determinants by linking them to data of the National Health Interview and Examination Survey for Children and Adolescents (KiGGS). Parents reported on the time their children usually spend at home, in other indoor environments, and outdoors. This information was characterized by statistical parameters, which were also calculated for different strata concerning socio-demography and the residential environment. Consequently, group differences were evaluated by t-tests and univariate ANOVA. Reference distributions were fitted to the time-location data by a Maximum Likelihood approach to make them also useable in probabilistic exposure modeling. Finally, associations between data on the children's physical activity as well as body weight and their outdoor time were investigated by bivariate correlation analysis and cross tabulation. On daily average, German children spend 15 h and 31 min at home, 4 h and 46 min in other indoor environments, and 3 h and 43 min outdoors. Time spent at home and outdoors decreases with age while time spent in other indoor environments increases. Differences in time-location patterns were also observed for the socio-economic status (SES) and immigration status. E.g., children with a high SES spend 24 min less outdoors than low SES children. Immigrants spend on daily average 20 min more at home and 15 min less outdoors than non-immigrant children. Outdoor time was associated with parameters of the residential environment like the building development. Children living in 1- or 2-family houses spend more time outdoors than children living in building blocks (3 h 48 min vs. 3 h 29 min). Physical activity correlates with outdoor time. For children with diminished age-specific outdoor time, a higher prevalence of obesity was observed (odds ratio: 3.2, 95% CI: 1.5–7.1). GerES IV provides a compilation of current time-location reference values and distributions on German children. This data hint to substantial differences in time-location patterns within the population to be considered in environmental health risk assessment.
A STUDY OF RULE-BASED CATEGORIZATION WITH REDUNDANCY
Creators: name: Shamloo, Farzin
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Cognitive and computational psychology not elsewhere classified

description: In tasks with more than one path to succeed, it is possible that participants’ strategies vary and therefore, participants should not be analyzed as a homogeneous group. This thesis investigates individual differences in a two-dimensional categorization task with redundancy (i.e., a task where any of the two dimensions by itself suffices for perfect performance). Individual differences in learned knowledge and used knowledge are considered and studied. Participants first performed a categorization task with redundancy (training phase), and afterward were asked to do categorizations in which the previously redundant knowledge becomes decisive (testing phase). Using the data from the testing phase, dimension(s) learned by each participant were determined and the response patterns of each participant in the training phase was used to determine which dimension(s) were used. The used knowledge was assessed using two separate analyses, both of which look at accuracy and response time patterns, but in different ways. Analysis 1 uses iterative decision bound modeling and RT-distance hypothesis and Analysis 2 uses the stochastic version of general recognition theory. In Analysis 1, more errors and slower response times close to a decision bound perpendicular to a dimension indicate that a participant is using that dimension. Analysis 2 goes a step further and in addition to determining which dimension(s) are used, specifies in what way they were used (i.e., identifying the strategy of each participant). Possible strategies are described heuristically (unidimensional, time efficient and conservative) and then each heuristic is translated into a drift diffusion model by the unique way that strategy is assumed to affect trial-by-trial difficulty of the task. Finally, a model selection criterion is used to pick the strategy that is used by each participant.
A real‑world pharmacovigilance study of raloxifene based on the FDA adverse event reporting system (FAERS)
Creators: name: Liu, Hao
name: Yan, Wei
name: Luo, Di
name: Li, Jinsong
name: Yan, Dezhi
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy

description: Raloxifene was approved for the treatment of postmenopausal osteoporosis; however, its safety profile remains inadequately understood. This study aimed to evaluate the safety signals associated with raloxifene. Adverse events (AEs) related to raloxifene, spanning from the first quarter of 2004 to the fourth quarter of 2023, were extracted from the FDA Adverse Event Reporting System (FAERS) database. A disproportionality analysis was conducted using several methods, including the reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), and Empirical Bayes Geometric Mean (EBGM). The analysis yielded 7 229 reports related to raloxifene across 19 277 AEs. A total of 217 significantly disproportionate signals were identified, including muscle spasms and hot flashes. Notably, the study also uncovered novel AEs, including eye conditions like cataracts and macular degeneration, as well as gynecological issues like uterine polyps and hemorrhage. Additionally, the analysis confirmed that pulmonary embolism and deep vein thrombosis were the two most prevalent thromboembolic AEs. Our study reaffirmed some existing safety information regarding raloxifene while also unveiling novel risk signals. The findings provided crucial insights to enhance the rational use of the drug and inform safety regulatory strategies.
The burden of extrapulmonary and meningitis tuberculosis: an investigation of national surveillance data, Germany, 2002 to 2009
Creators: name: Ducomble, Tanja
name: Tolksdorf, Kristin
name: Karagiannis, Ioannis
name: Hauer, Barbara
name: Brodhun, Bonita
name: Haas, Walter
name: Fiebig, Lena
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2013
Subjects: subject: Humans
subject: Annual Reports as Topic
subject: Bacterial Infections
subject: Europe
subject: Publications
subject: 610 Medizin

description: Tuberculosis (TB) surveillance commonly focuses on pulmonary (PTB) where the main organ affected is the lung. This might lead to underestimate extrapulmonary TB (EPTB) forms, where in addition to the lung other sites are affected by TB. In Germany, TB notification data provide the main site and the secondary site of disease. To gain an overview of all the different EPTB forms, we analysed German TB notification data between 2002 and 2009 using information on both main and secondary disease site to describe all individual EPTB forms. Further, we assessed factors associated with meningitis using multivariable logistic regression. Solely analysing the main site of disease, lead to one third of EPTB manifestations being overlooked. Case characteristics varied substantially across individual extrapulmonary forms. Of 46,349 TB patients, 422 (0.9%) had meningitis as main or secondary site. Of those, 105 (25%) of the 415 with available information had died. Multivariable analysis showed that meningitis was more likely in children younger than five years and between five and nine years-old (odds ratio (OR): 4.90; 95% confidence interval (CI): 3.40–7.07 and OR: 2.65; 95% CI: 1.40–5.00), in females (OR: 1.42; 95% CI: 1.17–1.73), and in those born in the World Health Organization (WHO) regions of south-east Asia (OR: 2.38; 95% CI: 1.66–3.43) and eastern Mediterranean (OR: 1.51; 95% CI: 1.02–2.23). Overall, EPTB manifestations, including meningitis, which is often fatal, were underestimated by routine analysis. We thus recommend using all information on disease manifestation generated by surveillance to monitor severe forms and to transfer the gained knowledge to TB case management where awareness of EPTB is most important.
Framing Entitlements, Framing Inequality: How State Policies on Food and Care Enable Women to Challenge or Adapt to Inequality
Creators: name: Krishnan, Preethi
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Sociology not elsewhere classified

description: This dissertation examines the role state-society dynamics play in influencing how people negotiate inequality. In particular, I analyze the interdependent relationship between state policies and the frames people use to interpret unequal access to food and care. While state policies shape people’s frames, people also negotiate with state policies to deploy frames that either challenge or adapt to inequality. Using in-depth observations, policy documents, and 50 semi-structured interviews with mothers, Anganwadi workers (childcare workers), union leaders, and state representatives associated with the Integrated Child Development Services (ICDS), a welfare program in India, I show that state-society dynamics are central to how inequality is sustained and challenged. When welfare policies encourage collectivization, disadvantaged groups appropriate policy frames to strengthen entitlement frames and in the process, challenge inequality. I refer to this mechanism as frame appropriation. In contrast, policies such as privatization encourage individualization, particularly in economically mobile groups, who then adopt neoliberal frames such as personal responsibility and choice, to weaken entitlement frames through a mechanism I call reactive adoption. Thus, alongside social movements that has made possible historically significant policy reforms, the path to social change also comes alive in daily interactions where policies mediate people’s everyday lives.
sj-pdf-2-ict-10.1177_15347354211031650 – Supplemental material for Traditional Chinese Medicine in Cancer Care: An Overview of 5834 Randomized Controlled Trials Published in Chinese
Creators: name: Lu, Chun-Li
name: Li, Xun
name: Zhou, Hong-Mei
name: Zhang, Chi
name: Yang, Ya-Yue
name: Feng, Ru-Li
name: Long, Chao-Jun
name: Deng, Fang-Yuan
name: Li, Jing-Chun
name: Cao, Ze-Ming
name: Mao, Qi-Yuan
name: Zhu, Jin-Pu
name: Hong, Yan-Fei
name: Huang, Shou-Yu
name: Qiu, Jia-Ying
name: Liu, Yi-Xiu
name: Wang, Ying
name: Yan, Yu-Qian
name: Dong, Jia-Min
name: Luo, Yu-Xin
name: Chen, Yun-Meng
name: Guan, Ying-Jie
name: Wieland, Lisa Susan
name: Robinson, Nicola
name: Liu, Jian-Ping
Publisher: name: SAGE Journals
Year: 2021
Subjects: Health and Community Services
Endocrinology
Oncology and Carcinogenesis not elsewhere classified
Aged Health Care

description: Supplemental material, sj-pdf-2-ict-10.1177_15347354211031650 for Traditional Chinese Medicine in Cancer Care: An Overview of 5834 Randomized Controlled Trials Published in Chinese by Chun-Li Lu, Xun Li, Hong-Mei Zhou, Chi Zhang, Ya-Yue Yang, Ru-Li Feng, Chao-Jun Long, Fang-Yuan Deng, Jing-Chun Li, Ze-Ming Cao, Qi-Yuan Mao, Jin-Pu Zhu, Yan-Fei Hong, Shou-Yu Huang, Jia-Ying Qiu, Yi-Xiu Liu, Ying Wang, Yu-Qian Yan, Jia-Min Dong, Yu-Xin Luo, Yun-Meng Chen, Ying-Jie Guan, Lisa Susan Wieland, Nicola Robinson and Jian-Ping Liu in Integrative Cancer Therapies
Additional file 1 of Effects of high-grain diet feeding on fatty acid profiles in milk, blood, muscle, and adipose tissue, and transcriptional expression of lipid-related genes in muscle and adipose tissue of dairy cows
Creators: name: Cui, Qiaorong
name: Lin, Limei
name: Lai, Zheng
name: Mao, Shengyong
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Computational Biology

description: Additional file 1: Table S1. Primer sequences are used for real-time PCR analysis. Fig. S1. Regulation of lipolysis in adipocytes signaling KEGG pathway in muscle tissue. Fig. S2. Biosynthesis of unsaturated fatty acids signaling KEGG pathway in muscle tissue. Fig. S3. PPAR signaling KEGG pathway in muscle tissue. Fig. S4. Fatty acid biosynthesis signaling KEGG pathway in adipose tissue. Fig. S5. Linoleic acid metabolism signaling KEGG pathway in adipose tissue. Fig. S6. PPAR signaling KEGG pathway in adipose tissue.
Additional file 3 of Supratentorial CNS-PNETs in children; a Swedish population-based study with molecular re-evaluation and long-term follow-up
Creators: name: Schepke, Elizabeth
name: Löfgren, Maja
name: Pietsch, Torsten
name: Kling, Teresia
name: Nordborg, Claes
name: Olsson Bontell, Thomas
name: Holm, Stefan
name: Öberg, Anders
name: Nyman, Per
name: Eliasson-Hofvander, Marie
name: Sabel, Magnus
name: Lannering, Birgitta
name: Carén, Helena
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Cell Biology
Neuroscience
Cancer

description: Additional file 3. Histopathological diagnoses and corresponding methylation class for the 13 tumour samples with a calibrated score < 0.9.
Prävalenz von Herzinfarkt und koronarer Herzkrankheit bei Erwachsenen im Alter von 40 bis 79 Jahren in Deutschland
Creators: name: Gößwald, Antje
name: Schienkiewitz, Anja
name: Nowossadeck, Enno
name: Busch, Markus
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2013
Subjects: subject: Gesundheitssurvey
subject: Prävalenz
subject: Koronare Herzkrankheit
subject: Herzinfarkt
subject: Prevalence
subject: Health survey
subject: Coronary heart disease
subject: Myocardial
subject: infarction
subject: 610 Medizin

description: In der Studie zur Gesundheit Erwachsener in Deutschland (DEGS1) wurden von 2008 bis 2011 in einer bevölkerungsrepräsentativen Stichprobe von 5901 Personen in der Altersgruppe von 40 bis 79 Jahren Daten zur Prävalenz von Herzinfarkt und koronarer Herzkrankheit erhoben. Die Ergebnisse von DEGS1 wurden mit denen aus dem Bundes-Gesundheitssurveys 1998 (BGS98) verglichen. Die Lebenszeitprävalenz des Herzinfarktes bei 40- bis 79-Jährigen in DEGS beträgt 4,7% (Frauen 2,5%; Männer 7%). Im Vergleich zum BGS98 zeigte sich ein geringer Anstieg bei Männern, nicht jedoch bei Frauen. Die Lebenszeitprävalenz der koronaren Herzkrankheit bei 40- bis 79-Jährigen beträgt in DEGS1 9,3% (Frauen 6,4%; Männer 12,3%). Im Vergleich zum BGS98 ergibt sich nur bei Frauen eine geringe Abnahme. Es besteht ein signifikanter inverser Zusammenhang zwischen Erkrankungshäufigkeit und Sozialstatus. Die Entwicklung der Prävalenzen der koronaren Herzkrankheit ist vergleichbar mit der in anderen industrialisierten Ländern. Bei sinkender Inzidenz des Herzinfarktes und einem Rückgang der Mortalitätsraten aufgrund koronarer Herzkrankheit spricht die im Wesentlichen gleichbleibende Prävalenz für eine positive Entwicklung im Bereich der kardiovaskulären Prävention und Therapie.
description: In the German Health Interview and Examination Survey for Adults (DEGS1), data on the prevalence of myocardial infarction and coronary heart disease were collected from 2008–2011 in a representative population-based sample of 5,901 adults aged 40–79 years. The results of DEGS1 were compared with the prevalence estimates from the German National Health Interview and Examination Survey 1998 (GNHIES98). The lifetime prevalence of myocardial infarction amongst 40–79 year olds in DEGS1 is 4.7% (women 2.5%; men 7%). In comparison with GNHIES98 a small increase was observed in men, but not in women. The lifetime prevalence of coronary heart disease in adults aged 40–79years in DEGS1 is 9.3% (women 6.4%; men 12.3%). In comparison to GNHIES98 there is a slight reduction only in women. There is a significant inverse relationship between disease prevalence and socioeconomic status. The trend in prevalence of coronary heart disease is comparable with that in other high-income countries. Given a falling incidence of myocardial infarction and a decrease in the mortality rates due to coronary heart disease, the basically stable prevalence rates indicate a positive development in the field of cardiovascular prevention and therapy. An English full-text version of this article is available at SpringerLink as supplemental.
sj-pdf-3-prf-10.1177_02676591211031095 – Supplemental material for Del Nido cardioplegia for myocardial protection in adult cardiac surgery: a systematic review and update meta-analysis
Creators: name: Zhai, Kerong
name: Cheng, Xingdong
name: Zhang, Pengbin
name: Wei, Shilin
name: Huang, Jian
name: Wu, Xiangyang
name: Gao, Bingren
name: Li, Yongnan
Publisher: name: SAGE Journals
Year: 2021
Subjects: Cardiology
Surgery

description: Supplemental material, sj-pdf-3-prf-10.1177_02676591211031095 for Del Nido cardioplegia for myocardial protection in adult cardiac surgery: a systematic review and update meta-analysis by Kerong Zhai, Xingdong Cheng, Pengbin Zhang, Shilin Wei, Jian Huang, Xiangyang Wu, Bingren Gao and Yongnan Li in Perfusion
"Performing Reparative Transgender Identities from Stage Beauty to The King and the Clown," Trans Historical: Gender Plurality before the Modern, ed. Greta LaFleur, Masha Raskolnikov, and Anna Klosowska (Cornell University Press, 2021), 322-349
Creators: name: Joubin, Alexa Alice
Publisher: name: Cornell University Press
Year: 2021
Subjects: subject: Shakespeare, William, 1564-1616
subject: Feminism
subject: Theater
subject: Renaissance
subject: Film criticism
subject: History

description: Analyzing trans narratives about the early moderns through the lenses of affective labor and social reparation, this chapter reclaims as trans the Shakespeare films that have been misinterpreted as homosexual. In doing so, this chapter builds a longer, more intersectional history of gendered embodiment. Reparative trans performances—works in which characters see their conditions improve—carry substantial affective rewards by offering optimism and emotional gratification, as exemplified by two recent films about early modern theatre making. The South Korean blockbuster The King and the Clown (dir. Lee Joon-ik, 2005) delineates the love triangle between a fifteenth-century king, a masculine jester, and a trans feminine character. Stage Beauty (dir. Richard Eyre, Lions Gate, 2004) chronicles the private life and stage career of the historical boy actor Edward Kynaston (1640–1712) who plays exclusively female roles before taking on male roles on stage. By reading these two films in the context of trans cinema, this chapter makes an intervention in both transgender and Shakespeare studies by demonstrating new ways to interpret gender variance beyond just a dramatic device. :::: https://www.cornellpress.cornell.edu/book/9781501759505/trans-historical/#bookTabs=1 ::::: ISBN: 978-1501759505
Privacy Protection and Mobility Enhancement in Internet
Creators: name: Zhang, Ping
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Networking and communications

description: The Internet has substantially embraced mobility since last decade. Cellular data network carries majority of Internet mobile access traffic and become the de facto solution of accessing Internet in mobile fashion, while many clean-slate Internet mobility solutions were proposed but none of them has been largely deployed. Internet mobile users increasingly concern more about their privacy as both researches and real-world incidents show leaking of communication and location privacy could lead to serious consequences. Just the communication itself between mobile user and their peer users or websites could leak considerable privacy of mobile user, such as location history, to other parties. Additionally, comparing to ordinary Internet access, connecting through cellular network yet provides equivalent connection stability or longevity.
In this research we proposed a novelty paradigm that leverages concurrent far-side proxies to maximize network location privacy protection and minimize interruption and performance penalty brought by mobility. To avoid the deployment feasibility hurdle we also investigated the root causes impeding popularity of existing Internet mobility proposals and proposed guidelines on how to create an economical feasible solution for this goal. Based on these findings we designed a mobility support system offered as a value-added service by mobility service providers and built on elastic infrastructure that leverages various cloud aided designs, to satisfy economic feasibility and explore the architectural trade-offs among service QoS, economic viability, security and privacy.
Gesundheitsbezogene Lebensqualität bei Erwachsenen in Deutschland
Creators: name: Ellert, Ute
name: Kurth, Bärbel-Maria
Publisher: name: Robert Koch-Institut
Year: 2013
Subjects: subject: Gesundheitssurvey
subject: Gesundheitsbezogene Lebensqualität
subject: Erwachsene
subject: SF-36V2
subject: Health survey
subject: Adults
subject: Health related quality of life
subject: 610 Medizin

description: Ziel der vorliegenden Arbeit ist es, die gesundheitsbezogene Lebensqualität der deutschen Erwachsenenbevölkerung darzustellen und aktuelle repräsentative Normdaten für die Version 2 des SF-36 (SF-36V2) in der deutschen Bevölkerung zu liefern. In der Studie zur Gesundheit Erwachsener in Deutschland (DEGS1) wurde der SF-36V2 zur Messung der gesundheitsbezogenen Lebensqualität eingesetzt. Männer berichten in allen Bereichen eine bessere gesundheitsbezogene Lebensqualität verglichen mit Frauen, ein niedrigerer sozialer Status geht mit geringeren Werten in der gesundheitsbezogenen Lebensqualität einher. Das Vorhandensein einer oder mehrerer chronischer Krankheiten bringt Einbußen in allen Bereichen der gesundheitsbezogenen Lebensqualität mit sich. Die Allgemeine Gesundheit bei den Frauen ab dem Alter von 40 bis 49 Jahren und bei den Männern ab 50 bis 59 Jahren wird deutlich besser eingeschätzt, als vor 10 Jahren. Die Version 2 des SF-36 erweist sich als robustes Messinstrument der gesundheitsbezogenen Lebensqualität, das in der Lage ist, Unterschiede bezüglich soziodemografischer und gesundheitsbezogener Merkmale plausibel abzubilden.
description: The aim of this study is to describe health-related quality of life (HRQoL) of the German adult population and provide current representative normative data for the version 2 of the SF-36 (SF-36V2) in the German population. In the German Health Interview and Examination Survey for Adults (DEGS1) the SF-36V2 was used to measure health-related quality of life. Men report in all areas better HRQoL compared to women; a lower social status is associated with lower HRQoL values. Having one or more chronic diseases is associated with lower values in all dimensions of HRQoL. Compared to 10 years ago, the general health seems to be much better in women aged 40–49 years and older and in men aged 50–59 years and older. Version 2 of the SF-36 has proved to be a robust instrument of health-related quality of life that is able to plausibly map differences regarding sociodemographic and health characteristics. An English full-text version of this article is available at SpringerLink as supplemental.
sj-pdf-3-tar-10.1177_17534666211028072 – Supplemental material for LncRNA CASC2 is involved in the development of chronic obstructive pulmonary disease via targeting miR-18a-5p/IGF1 axis
Creators: name: Liu, Panpan
name: Zhang, Huali
name: Zeng, Haizhu
name: Meng, Yingxia
name: Gao, Hongchang
name: Zhang, Meilan
name: Zhao, Lei
Publisher: name: SAGE Journals
Year: 2021
Subjects: Aged Health Care
Pharmacology and Pharmaceutical Sciences not elsewhere classified
Respiratory Diseases

description: Supplemental material, sj-pdf-3-tar-10.1177_17534666211028072 for LncRNA CASC2 is involved in the development of chronic obstructive pulmonary disease via targeting miR-18a-5p/IGF1 axis by Panpan Liu, Huali Zhang, Haizhu Zeng, Yingxia Meng, Hongchang Gao, Meilan Zhang and Lei Zhao in Therapeutic Advances in Respiratory Disease
Additional file 1 of The natural history and burden of illness of metachromatic leukodystrophy: a systematic literature review
Creators: name: Chang, Shun-Chiao
name: Eichinger, Christian Stefan
name: Field, Polly
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Mental Health
Computational Biology

description: Additional file 1. Search strings for Embase (1974–2021 [search run on June 23, 2021]).
External quality assurance of the first wave of the German Health Interview and Examination Survey for Adults (DEGS1)
Creators: name: Pelz, I.
name: Pohlabeln, H.
name: Reineke, A.
name: Ahrens, W.
Publisher: name: Robert Koch-Institut
Year: 2013
Subjects: subject: Health survey
subject: Quality assurance
subject: Response
subject: Fieldwork
subject: Data management
subject: 610 Medizin

description: The quality management concept for the first wave of the German Health Interview and Examination Survey for Adults (DEGS1) included in addition to conducting internal quality assurance (QS) also the supervision by an external independent institute. After a restricted tendering procedure, the Leibniz Institute for Prevention Research and Epidemiology–BIPS was commissioned to conduct the external quality assurance. The external quality control included the review of the operation manuals, the training of the field staff, the execution of field work (including measurements), and the monitoring of sampling, response and data management. For the realization of the controls in these areas, test criteria were developed to reveal shortcomings early and to give recommendations for the internal quality assurance. This paper briefly describes the concept and the execution of the accompanying external quality assurance with regard to the above mentioned areas.
ATR-FTIR spectroscopy reveals genomic loci regulating the tissue response in high fat diet fed BXD recombinant inbred mouse strains
Creators: name: Dogan, Ayca
name: Lasch, Peter
name: Neuschl, Christina
name: Millrose, Marion K.
name: Alberts, Rudi
name: Schughart, Klaus
name: Naumann, Dieter
name: Brockmann, Gudrun A.
Publisher: name: Robert Koch-Institut
Year: 2013
Subjects: subject: Apoptosis
subject: Collagen
subject: Endoplasmic reticulum
subject: Remodeling
subject: Liver steatosis
subject: Viperin
subject: Collectin-11
subject: 610 Medizin

description: Background: Obesity-associated organ-specific pathological states can be ensued from the dysregulation of the functions of the adipose tissues, liver and muscle. However, the influence of genetic differences underlying gross-compositional differences in these tissues is largely unknown. In the present study, the analytical method of ATR-FTIR spectroscopy has been combined with a genetic approach to identify genetic differences responsible for phenotypic alterations in adipose, liver and muscle tissues. Results: Mice from 29 BXD recombinant inbred mouse strains were put on high fat diet and gross-compositional changes in adipose, liver and muscle tissues were measured by ATR-FTIR spectroscopy. The analysis of genotype-phenotype correlations revealed significant quantitative trait loci (QTL) on chromosome 12 for the content of fat and collagen, collagen integrity, and the lipid to protein ratio in adipose tissue and on chromosome 17 for lipid to protein ratio in liver. Using gene expression and sequence information, we suggest Rsad2 (viperin) and Colec11 (collectin-11) on chromosome 12 as potential quantitative trait candidate genes. Rsad2 may act as a modulator of lipid droplet contents and lipid biosynthesis; Colec11 might play a role in apoptopic cell clearance and maintenance of adipose tissue. An increased level of Rsad2 transcripts in adipose tissue of DBA/2J compared to C57BL/6J mice suggests a cis-acting genetic variant leading to differential gene activation. Conclusion: The results demonstrate that the analytical method of ATR-FTIR spectroscopy effectively contributed to decompose the macromolecular composition of tissues that accumulate fat and to link this information with genetic determinants. The candidate genes in the QTL regions may contribute to obesity-related diseases in humans, in particular if the results can be verified in a bigger BXD cohort.
Hemorrhagic events associated with tacrolimus: a real-world pharmacovigilance study
Creators: name: Teng, Haolin
name: Zhou, Honglan
name: Li, Faping
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Cancer
subject: Science Policy
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Tacrolimus is a potent macrolide immunosuppressant frequently used to prevent graft rejection in organ transplantation. Despite the known side effect of hemorrhage, there are no extensive descriptive series of patients who experience hemorrhage events associated with tacrolimus. We sought to review and describe tacrolimus-related hemorrhage events reported by healthcare professionals to the United States Food and Drug Association Adverse Event Reporting System (FAERS) database. The FAERS database (2004q1-2022q4) was retrospectively analyzed to characterize reporting of hemorrhage adverse events (AEs) with tacrolimus. Subgroup analysis was completed on the hemorrhage. A total of 75,310 tacrolimus-associated AEs were identified, of which 1,511 cases met specific inclusion/exclusion criteria with most occurring in the gastrointestinal tract (422 cases, 27.93% of all included cases). Death was reported in 558 patients (36.93% of hemorrhage cases), the most of which occurred in cases of brain hemorrhage (219 cases, 39.25% of death cases). Among definitive organ transplants, renal transplant was the most common indication for tacrolimus (62 cases, 4.10%) followed by bone marrow transplant (44 cases, 2.91%) and liver transplant (30 cases, 1.99%). This study presents the largest collective description of tacrolimus-related hemorrhage events. We additionally described a number of previously unreported tacrolimus-related hemorrhage events.
Athlete Activism Online: An Examination of Subsequent Fan Engagement
Creators: name: Feder, Lillian B
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Communication and media studies not elsewhere classified
Communication studies

description: The impact of athlete activism online remains understudied in academic scholarship. To gain a better understanding for fan response to athlete activism online, this study examines the patterns in perception and response among sports fans with respect to politically-charged content posted online by professional athletes. The purpose of this study is to use this understanding of fan response to help athletes and their representatives manage fan reaction to athletes’ politically-charged content. By examining fan response to politically-charged content, this study suggests principles for eliciting positive impact, fostering open discourse, and promoting awareness through social media. Patterns in perception and response among sports fans with respect to politically-charged content posted online by professional athletes were examined through in-depth interviews conducted with sports fans between the ages of 18 and 30 who follow the profiles of professional athletes on social media. An understanding of the potential benefits and drawbacks of athletes’ use of social media for social movements has been gained through an analysis of the emergent themes among perception and response patterns revealed by study participants. The emergent themes of this study inform recommendations for professional athletes posting politically-charged content online. The findings of this study suggest that athletes who post politically-charged content online should do so with their goals and audience in mind. Knowing their goals as well as their audience grants athletes the ability to frame their content accordingly, rendering them more likely to receive positive responses to the politically-charged content they post. Based on the findings of this study, athletes who frame politically-charged content as a narrative highlighting their lived experience and employing appeals to emotion and humor yield the most positive responses from otherwise uninterested or hostile fans. The insights gained from this study stand to fill the gap in existing literature surrounding athlete activism online.
Additional file 2 of The natural history and burden of illness of metachromatic leukodystrophy: a systematic literature review
Creators: name: Chang, Shun-Chiao
name: Eichinger, Christian Stefan
name: Field, Polly
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Mental Health
Computational Biology

description: Additional file 2. Search strings for Ovid MEDLINE (1946–2021 [search run on June 23, 2021]).
sj-docx-1-pss-10.1177_0956797621994767 – Supplemental material for Global Variation in Subjective Well-Being Predicts Seven Forms of Altruism
Creators: name: Rhoads, Shawn A.
name: Gunter, Devon
name: Ryan, Rebecca M.
name: Marsh, Abigail A.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: Neuroscience

description: Supplemental material, sj-docx-1-pss-10.1177_0956797621994767 for Global Variation in Subjective Well-Being Predicts Seven Forms of Altruism by Shawn A. Rhoads, Devon Gunter, Rebecca M. Ryan and Abigail A. Marsh in Psychological Science
Vanishing Theorems for the logarithmic de Rham complex of unitary local system
Creators: name: Li, Hongshan
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Algebraic and differential geometry

description: This work includes various proofs of cohomology vanishing for logarithmic de Rham complex of unitary local system defined on an open algebraic complex manifold, which has a projective compactification by normal crossing divisor
Cyclin-dependent kinase 4/6 inhibitor-associated pulmonary toxicity: a disproportionality analysis from 2015 to 2023 based on the FAERS database
Creators: name: Cheng, Qian
name: Qi, JunSheng
name: Zou, Shupeng
name: Shi, Xuan
name: Zhao, Yazheng
name: Ouyang, Mengling
name: Sun, Minghui
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer
subject: Mental Health

description: This study aimed to describe the pulmonary toxicity of cyclin-dependent kinase 4/6 inhibitors (CDK 4/6 inhibitors) (palbociclib, ribociclib, and abemaciclib) in patients being treated for breast cancer using the Food and Drug Administration Adverse Event Reporting System (FAERS) database. Disproportionality analysis was performed to assess pulmonary toxicity associated with CDK 4/6 inhibitors. Clinical characteristics, onset time, sensitivity analysis, subgroup analyses, drug combinations, comorbidities, and co-reported events were performed. Out of 83,505 CDK 4/6 inhibitor-related adverse events (AEs) documented in the FAERS database during the study period, 437 cases of pneumonitis, 555 cases of pulmonary edema, and 181 cases of pulmonary thrombosis related to CDK 4/6 inhibitors were analyzed. Pneumonitis and pulmonary thrombosis had the strongest signal strength in abemaciclib; pulmonary edema had the strongest signal strength in ribociclib. The median latency for pneumonitis, pulmonary edema, and pulmonary thrombosis was 66–173.5 days, 27–131 days, and 68–279 days, respectively. Pulmonary toxicity is statistically significant disproportionality in females as well as in patients over 60 years old. Abemaciclib was most strongly associated with pneumonitis and pulmonary thrombosis. Ribociclib was most strongly associated with pulmonary edema. The correlation with pulmonary toxicity was, in descending order, abemaciclib, ribociclib, and palbociclib.
Rollback: Leaving Women to Demons in Gene Wolfe's Fiction
Creators: name: McEvoy-Halston, Patrick
Publisher: name: unknown
Year: 2021
Subjects: subject: Twentieth century
subject: Horror
subject: Psychoanalysis
subject: American literature

description: Gene Wolfe, living though Severian, re-experiences via Thecla's characterization of him as not being worth enough to value highly for being what he thought he could only amount to her when he first met her, that is, simply a boy at hand, his own once being lured into the attentions' of his mother and then dismissed by her when she was done using him as distraction and stimulant, i.e. Silk's own role with his habitually depressed mother. He repeats in fiction because he is drawn to repeat early traumas, but also because via fiction he can try and rework a remedy, a temporary remedy, to help him stabilize. As the psychohistorian Lloyd DeMause characterizes the functions of wars, fiction too can give the same feeling of being "'in control and triumphing over feelings of rejection and helplessness.'" What he does is ally himself with a venue, with an entity, that Thecla would have felt as her primary antagonist in life, her mother.
Rollback: Leaving Women to Demons in Gene Wolfe's Fiction
Creators: name: McEvoy-Halston, Patrick
Publisher: name: Humanities Commons
Year: 2021
Subjects: subject: American literature
subject: Twentieth century
subject: Horror
subject: Psychoanalysis

description: Gene Wolfe, living though Severian, re-experiences via Thecla’s characterization of him as not being worth enough to value highly for being what he thought he could only amount to her when he first met her, that is, simply a boy at hand, his own once being lured into the attentions’ of his mother and then dismissed by her when she was done using him as distraction and stimulant, i.e. Silk’s own role with his habitually depressed mother.  He repeats in fiction because he is drawn to repeat early traumas, but also because via fiction he can try and rework a remedy, a temporary remedy, to help him stabilize. As the psychohistorian Lloyd DeMause characterizes the functions of wars, fiction too can give the same feeling of being “‘in control and triumphing over feelings of rejection and helplessness.’” What he does is ally himself with a venue, with an entity, that Thecla would have felt as her primary antagonist in life, her mother.
Alarming Proportions of Methicillin-Resistant Staphylococcus aureus (MRSA) in Wound Samples from Companion Animals, Germany 2010–2012
Creators: name: Vincze, Szilvia
name: Stamm, Ivonne
name: Kopp, Peter A.
name: Hermes, Julia
name: Adlhoch, Cornelia
name: Semmler, Torsten
name: Wieler, Lothar H.
name: Lübke-Becker, Antina
name: Walther, Birgit
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2014
Subjects: subject: Germany
subject: Animals
subject: Staphylococcal Infections/diagnosis
subject: Incidence
subject: Staphylococcal Infections/epidemiology
subject: Dogs
subject: Methicillin-Resistant Staphylococcus aureus/isolation & purification
subject: Cats
subject: Horses
subject: Pets/microbiology
subject: Staphylococcal Infections/veterinary
subject: Wounds and Injuries/microbiology
subject: Wounds and Injuries/veterinary
subject: 610 Medizin

description: Staphylococcus (S.) aureus is an important cause of wound infections in companion animals, and infections with methicillin-resistant S. aureus (MRSA) are of particular concern due to limited treatment options and their zoonotic potential. However, comparable epidemiological data on MRSA infections in dogs, cats and horses is scarce, also limiting the knowledge about possible links to MRSA isolates from human populations. To gain more knowledge about the occurrence and genotypic variation of MRSA among wound swabs of companion animal origin in Germany we performed a survey (2010–2012) including 5,229 samples from 1,170 veterinary practices. S. aureus was identified in 201 (5.8%) canine, 140 (12.2%) feline and 138 (22.8%) equine swabs from a total of 3,479 canine, 1,146 feline and 604 equine wounds, respectively. High MRSA rates were identified with 62.7%, 46.4% and 41.3% in S. aureus of canine, feline and equine origin, respectively. Further genotyping including spa typing and multilocus sequence typing (MLST) revealed a comparable distribution of spa types among canine and feline MRSA with CC22 (47.6%; 49.2%) and CC5 (30.2%; 29.2%) as predominant lineages followed by CC398 (13.5%; 7.7%) and CC8 (4.0%; 9.2%). In contrast, the majority of equine MRSA belonged to CC398 (87.7%). Our data highlight the importance of S. aureus and MRSA as a cause of wound infections, particularly in cats and horses in Germany. While “human-associated” MRSA lineages were most common in dogs and cats, a remarkable number of CC398-MRSA was detected in horses, indicating a replacement of CC8-MRSA as the predominant lineage within horses in Germany. These data enforce further longitudinal epidemiological approaches to examine the diversity and temporal relatedness of MRSA populations in humans and animals to assess probable sources of MRSA infections. This would enable a sound risk assessment and establishment of intervention strategies to limit the additional spread of MRSA.
Reducing the barriers against analytical epidemiological studies in investigations of local foodborne disease outbreaks in Germany – a starter kit for local health authorities
Creators: name: Werber, Dirk
name: Bernard, Helen
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2014
Subjects: subject: Humans
subject: Female
subject: Germany/epidemiology
subject: Risk Factors
subject: Public Health
subject: Population Surveillance/methods
subject: Disease Outbreaks
subject: Foodborne Diseases/epidemiology
subject: Food Contamination/statistics & numerical data
subject: Foodborne Diseases/etiology
subject: Foodborne Diseases/microbiology
subject: Guidelines as Topic
subject: 610 Medizin

description: Thousands of infectious food-borne disease outbreaks (FBDO) are reported annually to the European Food Safety Authority within the framework of the zoonoses Directive (2003/99/EC). Most recognised FBDO occur locally following point source exposure, but only few are investigated using analytical epidemiological studies. In Germany, and probably also in other countries of the European Union, this seems to be particularly true for those investigated by local health authorities. Analytical studies, usually cohort studies or case–control studies, are a powerful tool to identify suspect food vehicles. Therefore, from a public health and food safety perspective, their more frequent usage is highly desirable. We have developed a small toolbox consisting of a strategic concept and a simple software tool for data entry and analysis, with the objective to increase the use of analytical studies in the investigation of local point source FBDO in Germany.
A real-world drug safety surveillance study of lenvatinib from the FAERS database
Creators: name: Yang, Yipin
name: Wang, Yafen
name: Chen, Bangjie
name: Liu, Yuchen
name: Gu, Kangsheng
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology

description: There is a need to determine lenvatinib-associated real-world adverse events (AEs) as its adverse effects may result in its discontinuation. Lenvatinib-associated AEs were analyzed and quantified and risk signals from the first quarter of 2015 to the fourth quarter of 2023 were detected through data mining. Potential targets for lenvatinib-associated cholecystitis, cholangitis, and hepatic encephalopathy were identified by data mining. 68 Preferred Terms (PTs) with an important imbalance were kept. Unexpected AEs, such as immune-mediated hepatitis, portal vein thrombosis and adrenal insufficiency were associated with the use of lenvatinib use. Lenvatinib alone was more strongly associated with adrenal insufficiency than lenvatinib and pembrolizumab combination. Hepatic encephalopathy was more strongly correlated with drug use when Lenvatinib was administered to male patients with hepatocellular carcinoma. Most AEs occurred during the first month after treatment, with a median onset time of 41 days. FGFR4, PDGFRA, and KIT (Lenvatinib targets) are potentially linked to cholecystitis, cholangitis, and hepatic encephalopathy. We identified Lenvatinib-associated AEs and discovered new AEs that will be useful for clinical monitoring and risk assessment.
Additional file 3 of The natural history and burden of illness of metachromatic leukodystrophy: a systematic literature review
Creators: name: Chang, Shun-Chiao
name: Eichinger, Christian Stefan
name: Field, Polly
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Mental Health
Computational Biology

description: Additional file 3. Search strings for Cochrane Library (search run on 23 June 2021).
sj-pdf-1-jcb-10.1177_0271678X211029197 - Supplemental material for MRI investigation of vascular remodeling for heterogeneous edema lesions in subacute ischemic stroke rat models: Correspondence between cerebral vessel structure and function
Creators: name: Kang, MungSoo
name: Jin, Seokha
name: Cho, HyungJoon
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110305 Emergency Medicine
subject: FOS: Clinical medicine
subject: 110306 Endocrinology
subject: Medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: 110320 Radiology and Organ Imaging
subject: Cell Biology
subject: Biochemistry
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Neuroscience

description: Supplemental material, sj-pdf-1-jcb-10.1177_0271678X211029197 for MRI investigation of vascular remodeling for heterogeneous edema lesions in subacute ischemic stroke rat models: Correspondence between cerebral vessel structure and function by MungSoo Kang, Seokha Jin and HyungJoon Cho in Journal of Cerebral Blood Flow & Metabolism