cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Different Adiabatic Quantum Optimization Algorithms for the NP-Complete Exact Cover and 3SAT Problems
Creators: name: Choi, Vicky
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: Computational Complexity (cs.CC)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: One of the most important questions in studying quantum computation is: whether a quantum computer can solve NP-complete problems more efficiently than a classical computer? In 2000, Farhi, et al. (Science, 292(5516):472--476, 2001) proposed the adiabatic quantum optimization (AQO), a paradigm that directly attacks NP-hard optimization problems. How powerful is AQO? Early on, van Dam and Vazirani claimed that AQO failed (i.e. would take exponential time) for a family of 3SAT instances they constructed. More recently, Altshuler, et al. (Proc Natl Acad Sci USA, 107(28): 12446--12450, 2010) claimed that AQO failed also for random instances of the NP-complete Exact Cover problem. In this paper, we make clear that all these negative results are only for a specific AQO algorithm. We do so by demonstrating different AQO algorithms for the same problem for which their arguments no longer hold. Whether AQO fails or succeeds for solving the NP-complete problems (either the worst case or the average case) requires further investigation. Our AQO algorithms for Exact Cover and 3SAT are based on the polynomial reductions to the NP-complete Maximum-weight Independent Set (MIS) problem.
description: This is the second part of article arXiv:quant-ph/1004.2226. References added
Infrastructures of vulnerability, or, how the Fraser Valley flooded twice
Creators: name: Gandolfo-Lucia, Nick
Publisher: name: University of British Columbia
Year: 2022

description: In November and December of 2021, major floods occurred in the Fraser Valley of British Columbia due to exceptional rainfall from an atmospheric river. As Justin Trudeau stoically informed the House of Commons, the unusual weather pattern that precipitated this event was likely an effect of anthropogenic climate change. However, the flooding of the Fraser Valley was not only due to new, more extreme weather patterns: for the last 150 years, flooding has been a persistent danger in this area. Drawing on a range of archival sources, I argue that the expansion and movement of the Fraser River was transformed into a hazard through the processes of colonial and capitalist development in the valley that followed the goldrush of 1858. These processes differentially rendered the inhabitants of the valley vulnerable to flooding. The introduction outlines this argument in the context of the floods of 2021. In Chapter 1, I provide a sympathetic critique of prevailing conceptions of vulnerability in geographic thought, arguing that vulnerability to flood hazards is not an inherent quality of individuals. Rather, individuals are produced as vulnerable through the socioecological relations in which they exist. Chapter 2 returns to the Fraser Valley. I show how the seasonal rhythms of the river, which had long been used by First Peoples for subsistence and cultural purposes, were rendered disastrous through the colonization of the valley and the imposition of European-style agriculture in the late 19th century. The vulnerability of settler-farmers to flooding led to the provincial state taking over the task of diking the valley in 1898. Significantly, however, the construction of this intervention introduced new vulnerabilities: the need to fund and maintain the dikes, dams, floodgates, and pumps on which agriculture in the valley depends. In Chapter 3, I show how these vulnerabilities were dramatically realized in the flood of 1948. After the flood, dikes and other infrastructures were rebuilt, ensuring that this vulnerability endured. Lastly, in the conclusion, I briefly highlight recent proposals from community groups around the Fraser Valley, particularly First Nations, to find alternative ways of managing flooding that do not rely on traditional dikes.
Additional file 3 of Outcomes of surgical treatment with patterns of bacterial culture and antimicrobial susceptibility testing in cases of cervical abscessation in dogs: 82 cases (2018–2021)
Creators: name: Walker, Alexandra
name: Amato, Nicole
name: Brisson, Jennifer
name: Stewart, Samuel
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Supplementary Fig. S3: A table showing dog breeds represented in this study.
QSOFEED: The relationship between star formation and AGN Feedback
Creators: name: Bessiere, Patricia S.
name: Almeida, Cristina Ramos
name: Holden, Luke R.
name: Tadhunter, Clive N.
name: Canalizo, Gabriela
Publisher: name: arXiv
Year: 2024
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Large-scale cosmological simulations suggest that feedback from active galactic nuclei (AGN) plays a crucial role in galaxy evolution. In this study, we directly test this hypothesis utilising SDSS spectra of a sample of 48 low redshift (z<0.14) type 2 quasars (QSO2s). We characterised the kinematics of the warm ionised gas by performing a non-parametric analysis of the [OIII]$λ5007$ emission line, as well as constrain the properties of the young stellar populations (YSP) of their host galaxies through spectral synthesis modelling. These analyses revealed that 85% of the QSO2s display gas velocity dispersions larger than that of the stellar component of their host galaxies, indicating the presence of AGN-driven outflows. Comparing the gas kinematics to the AGN properties, we found a positive correlation between gas velocity dispersion and 1.4 GHz radio luminosity but not with AGN bolometric luminosity or Eddington ratio, suggesting that, either the radio luminosity is the key factor in driving outflows or that the outflows themselves are shocking the ISM and producing synchrotron emission. We found that 98% of the sample host YSPs to varying degrees, with star formation rates (SFR) $0 \le SFR \le 92 \mbox{ M}_{\odot} \mbox{yr}^{-1}$, averaged over 100 Myr. We compared the gas kinematics and outflow properties to the SFRs to establish possible correlations which may suggest that the presence of the outflowing gas is impacting SF and find that none exists, leading to the conclusion that, on the scales probed by the SDSS fibre, AGN-driven outflows do not impact SF on the timescales probed in this study. However, we found a positive correlation between the light-weighted stellar ages of the QSO2s and the black hole mass, which may indicate that successive AGN episodes lead to the suppression of SF over the course of galaxy evolution.
description: 15 pages including 12 Figures. Three additional appendices including 2 long Figures and 4 Tables. Accepted for publication in Astronomy and Astrophysics (A&A)
Additional file 1 of Role of psychosocial factors on the effect of physical activity on physical function in patients after lumbar spine surgery
Creators: name: Master, Hiral
name: Castillo, Renan
name: Wegener, Stephen T.
name: Pennings, Jacquelyn S.
name: Coronado, Rogelio A.
name: Haug, Christine M.
name: Skolasky, Richard L.
name: Riley, Lee H.
name: Neuman, Brian J.
name: Cheng, Joseph S.
name: Aaronson, Oran S.
name: Devin, Clinton J.
name: Archer, Kristin R.
Publisher: name: figshare
Year: 2021
Subjects: subject: Biophysics
subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Supplementary Table 1. Standardized regression weights (SRW) and standard errors (SE) for SEM mediation models of physical activity, physical function, and pain self-efficacy from 6 weeks to 24 months after lumbar spine surgery (N=248). Supplementary Table 2. Standardized regression weights (SRW) and standard errors (SE) for SEM mediation models of physical activity, physical function, and depression from 6 weeks to 24 months after lumbar spine surgery (N=248). Supplementary Table 3. Standardized regression weights (SRW) and standard errors (SE) for SEM mediation models of physical activity, physical function, and fear of movement from 6 weeks to 24 months after lumbar spine surgery (N=248).
Additional file 1 of Internal and external aspects of freedom of choice in mental health: cultural and linguistic adaptation of the Hungarian version of the Oxford CAPabilities questionnaire—Mental Health (OxCAP-MH)
Creators: name: Helter, Timea Mariann
name: Kovacs, Ildiko
name: Kanka, Andor
name: Varga, Orsolya
name: Kalman, Janos
name: Simon, Judit
Publisher: name: figshare
Year: 2021
Subjects: subject: Linguistics
subject: FOS: Languages and literature

description: Additional file 1: Comparison of translation procedures in the German and Hungarian versions of OxCAP-MH.
Intermediate-pressure phases of cerium studied by an LDA + Gutzwiller method
Creators: name: Tian, Ming-Feng
name: Deng, Xiaoyu
name: Fang, Zhong
name: Dai, Xi
Publisher: name: arXiv
Year: 2011
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The thermodynamic stable phase of cerium metal in the intermediate pressure regime (5.0--13.0 GPa) is studied in detail by the newly developed local-density approximation (LDA)+ Gutzwiller method, which can include the strong correlation effect among the 4\textit{f} electrons in cerium metal properly. Our numerical results show that the $α"$ phase, which has the distorted body-centered-tetragonal structure, is the thermodynamic stable phase in the intermediate pressure regime and all the other phases including the $α'$ phase ($α$-U structure), $α$ phase (fcc structure), and bct phases are either metastable or unstable. Our results are quite consistent with the most recent experimental data.
description: 17 pages, 7 figures
Clinical characteristics and symptom burden of Thai myeloproliferative neoplasm patients
Creators: name: Cherdchoo, Naritsara
name: Polprasert, Chantana
name: Rojnuckarin, Ponlapat
name: Kongkiatkamon, Sunisa
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Hematology

description: Objective Patients living with myeloproliferative neoplasms (MPNs) suffer from symptom burden that affect quality of life. Due to the differences in cultures, climates, and genetic background, we aimed to investigate the symptom burden of Thai MPN patients Methods A comprehensive survey using the MPN-10 questionnaire was carried out between September 1, 2014, and September 30, 2017. The scores obtained were then correlated with clinical outcomes.. Results A total of 145 patients were enrolled. Nearly 90% of patients reported being symptomatic. The mean MPN-10 score was 13.6 (SD = 11). The mean MPN-10 score was highest in PMF, whereas the mean score and intensity of individual items were surprisingly low in ET and PV. Notably, the mean MPN-10 score was significantly higher in patients with documented splenomegaly compared to those with a normal-sized spleen. However, there were no correlations between MPN-10 scores and the mutation status, disease complications such as thrombosis and hemorrhage, progression to myelofibrosis or leukemia, and mortality. Patients who needed regular transfusions reported a higher MPN-10 score compared to those who did not. Conclusion The MPN-10 score did not predict survival outcomes among Thai MPN patients. Higher MPN-10 was associated with more transfusion. Thai MPN patients reported lower MPN-10 compared to western population especially PV and ET.
Additional file 1 of Chemotherapy-induced weight gain in early-stage breast cancer: a prospective matched cohort study reveals associations with inflammation and gut dysbiosis
Creators: name: Walker, John
name: Joy, Anil Abraham
name: Vos, Larissa J.
name: Stenson, Trevor H.
name: Mackey, John R.
name: Jovel, Juan
name: Kao, Dina
name: Madsen, Karen L.
name: Wong, Gane Ka-Shu
Publisher: name: figshare
Year: 2023
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Additional file 1: Supplementary Methods. Methodological detail on patient stool sample collection and proteomic analysis.
CMB-PAInT: An inpainting tool for the cosmic microwave background
Creators: name: Gimeno-Amo, C.
name: Martínez-González, E.
name: Barreiro, R. B.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The presence of astrophysical emissions in microwave observations forces us to perform component separation to extract the Cosmic Microwave Background (CMB) signal. However, even in the most optimistic cases, there are still strongly contaminated regions, such as the Galactic plane or those with emission from extragalactic point sources, which require the use of a mask. Since many CMB analyses, especially the ones working in harmonic space, need the whole sky map, it is crucial to develop a reliable inpainting algorithm that replaces the values of the excluded pixels by others statistically compatible with the rest of the sky. This is especially important when working with $Q$ and $U$ sky maps in order to obtain $E$- and $B$-mode maps which are free from $E$-to-$B$ leakage. In this work we study a method based on Gaussian Constrained Realizations (GCR), that can deal with both intensity and polarization. Several tests have been performed to asses the validation of the method, including the study of the one-dimensional probability distribution function (1-PDF), E- and B-mode map reconstruction, and power spectra estimation. We have considered two scenarios for the input simulation: one case with only CMB signal and a second one including also Planck PR4 semi-realistic noise. Even if we are limited to low resolution maps, $N_{\mathrm{side}} = $ 64 if $T$, $Q$ and $U$ are considered, we believe that this is a useful approach to be applied to future missions such as LiteBIRD, where the target are the largest scales.
description: 26 pages, 24 figures. Minor changes in the text. New Appendix B. Updated to match the final version published in JCAP
A cross-sectional survey of symptoms and daily living among patients with polycythemia vera and their treating physicians in Japan
Creators: name: Edahiro, Yoko
name: Kirito, Keita
name: Gotoh, Akihiko
name: Takenaka, Katsuto
name: Sugimoto, Yuka
name: Komatsu, Norio
name: Shimoda, Kazuya
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: This Japanese cross-sectional survey evaluated the symptoms, daily living activities, and treatment needs of patients with polycythemia vera (PV), as perceived by patients themselves and their physicians. The study was conducted at 112 centers (March to July 2022) and included PV patients aged ≥20 years (n = 265) and their attending physicians (n = 151). The patient and physician questionnaires included 34 and 29 questions, respectively, to assess daily living, PV symptoms, treatment goals, and physician-patient communication. Concerning daily living (primary endpoint), work (13.2%), leisure activities (11.3%), and family life (9.6%) were most affected by PV symptoms. Patients aged <60 years more frequently reported an impact on daily living than patients aged ≥60 years. Some patients (30%) reported anxiety about their future condition. The most common symptoms were pruritus (13.6%) and fatigue (10.9%). Pruritus was ranked as the first treatment need for patients, while physicians ranked it fourth. Concerning treatment goals, physicians prioritized thrombosis/vascular event prevention, while patients prioritized delaying PV progression. Physicians were less satisfied with physician-patient communication than patients. Patients’ daily living was largely affected by PV symptoms. There are differences in physician and patient perceptions of symptoms, daily living, and treatment needs in Japan. UMIN Japan identifier: UMIN000047047.
Additional file 1 of Psychometric evaluation of the Indolent Systemic Mastocytosis Symptom Assessment Form (ISM-SAF) in a phase 2 clinical study
Creators: name: Padilla, Brad
name: Shields, Alan L.
name: Taylor, Fiona
name: Li, Xiaoran
name: Mcdonald, Jeffrey
name: Green, Tanya
name: Boral, Anthony L.
name: Lin, Hui-Min
name: Akin, Cem
name: Siebenhaar, Frank
name: Mar, Brenton
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Hematology
subject: 60506 Virology
subject: FOS: Biological sciences

description: Additional file 1: Demographic information and sensitivity to change results. Table S1. Sample demographic information at Baseline (N = 38). Table S2. Sensitivity to change: Correlation between ISM-SAF biweekly domain and total change scores and change in concurrently administered measures from Baseline to C4D1 (N = 36).
''Presencia'' de Juan Carlos Onetti. Píldora audiovisual
Creators: name: Francisca Noguerol Jiménez
name: Borja Cano Vidal
name: José Antonio Paniagua García
name: Andrea Elvira-Navarro
name: Vega Sánchez-Aparicio
Publisher: name: Zenodo
Year: 2022

description: Material docente elaborado en el seno del proyecto de Innovación Docente «Elaboración de píldoras audiovisuales para la enseñanza de la literatura hispanoamericana» (ID2021/076) concedido en la Universidad de Salamanca durante el curso académico 2021/2022.
Cosmological Constraints on the DGP braneworld model with Gamma-ray bursts
Creators: name: Liang, Nan
name: Zhu, Zong-Hong
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We investigate observational constraints on the Dvali, Gabadadze and Porrati (DGP) model with Gamma-ray bursts (GRBs) at high redshift obtained directly from the Union2 Type Ia supernovae data (SNe Ia) set. With the cosmology-independent GRBs, the Union2 set, as well as the cosmic microwave background (CMB) observations from the WMAP7 result, the baryon acoustic oscillation, the baryon mass fraction in clusters and the observed $H(z)$ data, we obtain that the best-fit values of the DGP model are ${Ω_{M0}, Ω_{rc}} =\{0.235_{-0.014}^{+0.015},0.138_{-0.048}^{+0.051}\}$, which favor a flat universe; and the transition redshift of the DGP model is $z_T=0.67_{-0.04}^{+0.03}$. These results lead to more stringent constraints than the previous results for the DGP model.
description: 9 pages, 1 figure, 1 table; accepted for publication in Res. Astron. Astrophys
Hyaluronan mediated motility receptor regulates daughter cell size control pathways during mitosis
Creators: name: Mei, Lin
Publisher: name: University of British Columbia
Year: 2022

description: During cell division, one mitotic cell generates two daughter cells. Molecular pathways that build, stabilize and orient the mitotic spindle are critical during cell division as the mitotic spindle ensures equal segregation of chromosomes and controls the size of the daughter cells. During anaphase, the spindle mid-zone signals the cleavage site, a site that defines the separation of the daughter cells in most animal cells. Under normal conditions, the spindle is centred in the dividing cell, leading to equal-sized daughter cells. However, daughter cells with different physical sizes can be generated due to an off-centre spindle during anaphase. Unequal-sized daughter cells differ in their relative amounts of cytoplasmic content, such as organelles, which can affect their survival, growth, and behavior. Several mechanisms regulate daughter cell size in mitosis, including asymmetric cortical dynein pulling forces on the spindle and asymmetric membrane elongation at the cell surface. The Maxwell Lab revealed that the gene product hyaluronan mediated motility receptor (HMMR) plays an important role in the asymmetric cortical localization and activity of dynein, a pulling-force generating microtubule motor protein. Moreover, HMMR is a breast cancer susceptibility gene. My research now shows that HMMR also regulates asymmetric membrane elongation to control daughter cell size. My results reveal that HMMR-overexpressing cells display ectopic membrane elongation at anaphase as well as the ultimate loss of daughter cell size control; moreover, elevated HMMR expression correlates with activation of Aurora kinase A and mis-localization of components of the ARP2/3 complex, which potentially disrupts the stability of the cortex during mitosis. Collectively, my research identifies a new role for HMMR in the regulation of cortical integrity and daughter cell sizes potentially through an Aurora kinase A-dependent control of ARP2/3 complex localization to the mitotic spindle poles. The disruption of daughter cell size control mediated by elevated HMMR expression may contribute to heterogeneous cell size and genome instability that often occurs during tumorigenesis.
Additional file 1 of Improvement of glycemic control and reduction of major cardiovascular events in 18 cardiovascular outcome trials: an updated meta-regression
Creators: name: Maiorino, Maria Ida
name: Longo, Miriam
name: Scappaticcio, Lorenzo
name: Bellastella, Giuseppe
name: Chiodini, Paolo
name: Esposito, Katherine
name: Giugliano, Dario
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy

description: Additional file 1. Additional figure and table.
On Identifying Significant Edges in Graphical Models of Molecular Networks
Creators: name: Scutari, Marco
name: Nagarajan, Radhakrishnan
Publisher: name: arXiv
Year: 2011
Subjects: subject: Machine Learning (stat.ML)
subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: Objective: Modelling the associations from high-throughput experimental molecular data has provided unprecedented insights into biological pathways and signalling mechanisms. Graphical models and networks have especially proven to be useful abstractions in this regard. Ad-hoc thresholds are often used in conjunction with structure learning algorithms to determine significant associations. The present study overcomes this limitation by proposing a statistically-motivated approach for identifying significant associations in a network. Methods and Materials: A new method that identifies significant associations in graphical models by estimating the threshold minimising the $L_{\mathrm{1}}$ norm between the cumulative distribution function (CDF) of the observed edge confidences and those of its asymptotic counterpart is proposed. The effectiveness of the proposed method is demonstrated on popular synthetic data sets as well as publicly available experimental molecular data corresponding to gene and protein expression profiles. Results: The improved performance of the proposed approach is demonstrated across the synthetic data sets using sensitivity, specificity and accuracy as performance metrics. The results are also demonstrated across varying sample sizes and three different structure learning algorithms with widely varying assumptions. In all cases, the proposed approach has specificity and accuracy close to 1, while sensitivity increases linearly in the logarithm of the sample size. The estimated threshold systematically outperforms common ad-hoc ones in terms of sensitivity while maintaining comparable levels of specificity and accuracy. Networks from experimental data sets are reconstructed accurately with respect to the results from the original papers.
description: 21 pages, 9 figures. Presented at the Conference for Artificial Intelligence in Medicine (AIME '11), Workshop on Probabilistic Problem Solving in Biomedicine
Clinical and biological profile of Sickle Cell Anemia children in a rural area in Central Africa
Creators: name: Mbayabo, Gloire
name: Ngole, Mamy
name: Lumbala, Paul Kabuyi
name: Lumaka, Aimé
name: Race, Valerie
name: Matthijs, Gert
name: Mikobi, Tite Minga
name: Devriendt, Koenraad
name: Van Geet, Chris
name: Lukusa, Prosper Tshilobo
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Sickle Cell Anemia (SCA) is the most common genetic disease worldwide caused by a single mutation in the gene HBB. The disease severity is very variable and depends on many factors. We evaluated the clinical and biological profile of sickle cell anemia children in rural Central Africa. This cross-sectional study was conducted in the Hôpital Saint Luc de Kisantu, located 120 km away from Kinshasa-DR Congo in an area of 35 km around Kisantu with a population of roughly 80 000 individuals. We included SCA patients aged 6 months to 18 years. We collected clinical and hematological data. The SCA scoring system proposed by Adegoke et al. in 2013 was applied to determine the disease severity. We searched for factors associated to the disease severity. This study included 136 patients, 66 males and 70 females (sex-ratio M/F 0.94). The mean severity score was 8.21 ± 5.30 (ranges 0–23). Fifty-nine (43.4%) children had mild disease, 62 (45.6%) moderate and 15 (11%) severe disease. Girls had higher levels of HbF than boys (p = 0.003). An inverse correlation was observed between fetal hemoglobin and the disease severity (p = 0.005, r −0.239, IC95% −6.139; −1.469). Some factors such age influence the occurrence of certain chronic complications such as avascular bone necrosis. In conclusion, the disease severity of SCA depends on multiple factors. In this study, fetal hemoglobin was the main modulator of the disease severity. These data may also serve as a baseline to initiate HU treatment in this setting.
On the Effect of Coronal Rain on Decayless Kink Oscillations of Coronal Loops
Creators: name: Shrivastav, Arpit Kumar
name: Pant, Vaibhav
name: Antolin, Patrick
Publisher: name: arXiv
Year: 2024
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Decayless kink oscillations are ubiquitously observed in active region coronal loops with an almost constant amplitude for several cycles. Decayless kink oscillations of coronal loops triggered by coronal rain have been analysed, but the impact of coronal rain formation in an already oscillating loop is unclear. As kink oscillations can help diagnose the local plasma conditions, it is important to understand how these are affected by coronal rain phenomena. In this study, we present the analysis of an event of coronal rain that occurred on 25 April 2014 and was simultaneously observed by \textit{Slit-Jaw Imager} (SJI) onboard \textit{Interface Region Imaging Spectrograph} (IRIS) and \textit{Atmospheric Imaging Assembly} (AIA) onboard \textit{Solar Dynamic Observatory} (SDO). The oscillation properties of the coronal loop in AIA are investigated before and after the appearance of coronal rain in SJI. We find signatures of decayless oscillations before and after coronal rain at similar positions to those during coronal rain. The individual cases show a greater amplitude and period during coronal rain. The mean period is increased by 1.3 times during coronal rain, while the average amplitude is increased by 2 times during rain, in agreement with the expected density increase from coronal rain. The existence of the oscillations in the same loop at the time of no coronal rain indicates the presence of a footpoint driver. The properties of the observed oscillations during coronal rain can result from the combined contribution of coronal rain and a footpoint driver. The oscillation amplitude associated with coronal rain is approximated to be 0.14 Mm. The properties of decayless oscillations are considerably affected by coronal rain, and without prior knowledge of coronal rain in the loop, a significant discrepancy can arise from coronal seismology with respect to the true values.
description: 12 pages. Accepted for publication in Astronomy & Astrophysics
Massive gravity generalization of $T\overline{T}$ deformations
Creators: name: Tsolakidis, Evangelos
Publisher: name: arXiv
Year: 2024
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Motivated by the two-dimensional massive gravity description of $T\overline{T}$ deformations, we propose a direct generalization in $d$ dimensions. Our methodology indicates that all terms up to order $d$ are present in the deformation. In two dimensions, $T\overline{T}$ is enhanced by a linear and a constant term, and exhibits an interesting behaviour regarding the deformed spectrum and correlators. At certain limits, this deformation can reduce to $T\overline{T}$ or $T\overline{T}+Λ_{2}$ consistently. Using the massive gravity method, we obtain the classically deformed action of a sigma model of bosons and fermions interacting with an arbitrary potential, extending previous results. As a consequence, a proposal regarding the deformation of higher-derivative theories is made. Moreover, a standard dimensional reduction procedure is presented, with the resulting operator matching the form of prior findings under certain assumptions. In $d\geq2$, we provide the exact structure of the quadratic terms in agreement with previous approaches, as well as the structure of the linear and constant terms. All higher order contributions are not easily evaluated, yet we derive the complete answer for all cases up to seven dimensions. Under certain conditions, these terms vanish, resulting in a quadratic operator. The trace-flow equation for this family of deformations is also derived. Finally, we investigate the class of root-$T\overline{T}$ operators in various dimensions within the scope of this formalism.
description: 30 pages plus appendices, 1 figure, 1 table, typos corrected, references added, matches published version
Additional file 1 of Yeast extracts from different manufacturers and supplementation of amino acids and micro elements reveal a remarkable impact on alginate production by A. vinelandii ATCC9046
Creators: name: Sparviero, Sarah
name: Dicke, Max Daniel
name: Rosch, Tobias M.
name: Castillo, Tania
name: Salgado-Lugo, Holjes
name: Galindo, Enrique
name: Peña, Carlos
name: Büchs, Jochen
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Additional file 1: Table S1. Conditions to be selected to achieve desired final values for selected cultivation features. Figure S1. Oxygen transfer rates of microaerobic A. vinelandii ATCC9046 cultivations with two different yeast extracts. Figure S2. Effect of different yeast extracts on A. vinelandii ATCC9046 cultivations at sufficient oxygen supply. Figure S3. Acetylation degree and final broth viscosity of A. vinelandii ATCC9046 cultivations with different yeast extracts. Figure S4. Final broth viscosity of microaerobic A. vinelandii ATCC9046 cultivations with varying yeast extract concentrations. Figure S5. Further analytics of A. vinelandii ATCC9046 cultivations, supplemented with vitamins, micro elements and trace elements. Figure S6. Further analytics of A. vinelandii ATCC9046 cultivations with supplementation of copper, zinc and manganese sulfate. Figure S7. Further analytics of microaerobic A. vinelandii ATCC9046 cultivations with supplementation of different grouped amino acids. Figure S8. Further analytics of microaerobic A. vinelandii ATCC9046 cultivations with supplementation of single amino acids. Figure S9. Further analytics of A. vinelandii ATCC9046 cultivations with supplementation of micro elements and amino acids.
Swallow-tail dispersions of moving solitons in a two-dimensional fermionic superfluid
Creators: name: Major, Jan
name: Brand, Joachim
Publisher: name: arXiv
Year: 2024
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: Soliton-like localised wave solutions in a two-dimensional Fermi superfluid are studied by solving the Bogoliubov-de Gennes equations in the BCS regime of weak pairing interactions. The dispersion relations of these solitons are found to exhibit a peculiar swallow-tail shape, with cusps and multiple branches. The effective mass of the solitons is found to diverge and change sign at the cusp. This behavior is in contrast to the smooth dispersion relations and negative effective masses of solitons in the three-dimensional Fermi superfluid. The swallow-tail dispersion relations are shown to be a consequence of counterflow of the superfluid and sign-changing contributions to the superfluid current from different transverse momenta in the Bogoliubov-de Gennes formalism. The results are relevant for the understanding of solitonic excitations in two-dimensional Fermi superfluids, such as ultracold atomic gases and high-temperature superconductors.
description: (12 pages, 9 figures, version submitted for review in Phys. Rev. A)
Additional file 2 of Differential enrichment of H3K9me3 at annotated satellite DNA repeats in human cell lines and during fetal development in mouse
Creators: name: Vojvoda Zeljko, Tanja
name: Ugarković, Đurđica
name: Pezer, Željka
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Text S1. Justification of using genomic median for normalization of signal between samples. Table S2. A. Raw signal statistics based on all genomic regions. B. Raw signal statistics based only on regions outside of blocklist. Text S2. Fraction of zero mapping quality reads at satellite elements. Figure S1. Reads that can be aligned to multiple positions in the genome are assigned zero mapping quality. The fraction of such reads was calculated for each satellite element outside of (A—all satellite elements and B—elements with FC > = 2) and on the blocklist (C) for two biological replicates of Hmec and A549 cells. Such fractions per satellite element are shown as density plots. Table S3. Number of annotated instances of satellite families in hg19. Table S4. Number of annotated instances of satellite families in mm10. Figure S2. Density plot of calculated fold change (ChIP over input) for normal and cancer cell lines at 4,406 annotated satellite elements outside of the blocklist. Dashed vertical lines represent median values. Figure S3. Enrichment for H3K9m3 at elements of annotated satellite families in normal and cancer cell lines. Asterisks denote satellite families with significant differences in H3K9me3 enrichment between normal and cancer cells (Welch Two Sample t-test; p-value
Using machine learning to identify and map controls of growing-season carbon dioxide and methane fluxes in the Mackenzie Delta region
Creators: name: Skeeter, June
Publisher: name: University of British Columbia
Year: 2022

description: With climate change, this permafrost carbon pool is at risk of destabilization and emission to the atmosphere. Two field campaigns were conducted in the Mackenzie Delta Region to measure carbon dioxide and methane fluxes with eddy covariance and chamber methods. Illisarvik, a drained thermokarst lake, was studied during the peak growing season in 2016. Fish Island, a low center polygonal peatland, was studied over the 2017 growing season. Half-hourly fluxes were calculated and filtered with quality control tests. Flux footprints were calculated and overlaid on landscape classification maps to estimate the relative flux contributions from different vegetation types and microtopographic features. For both data sets, neural networks (NN) were trained to map flux responses to large sets of potential soil and weather drivers and flux contributions by landscape classification. The NN were pruned to identify the strongest drivers, which is a novel approach that has not been applied to eddy covariance data elsewhere. The pruned NN were used to gap-fill the flux time series to calculate net ecosystem exchange (NEE) and net methane exchange (NME). The functional relationships identified by the NNs were visualized by plotting model derivatives and projecting estimates across the observed ranges of drivers. Radiative input and soil temperature were the primary determinants of NEE, and the NN were able to closely map the functional relationships. Spatial heterogeneity had a significant influence on NME and the NN estimates could not map the relationships as accurately. Further analysis was conducted with the Fish Island data. A set of surface observations from a weather station at Fish Island was paired with reanalysis and satellite data. Regression models were trained on the 2017 field data to estimate a time series of flux drivers and NN were used to project NEE and NME over the 2009 to 2019 snow-free seasons. These estimates contextualize the 2017 flux observations. They indicate Fish Island was a net growing season CO2 sink and CH4 source from 2009 to 2019, but shoulder season CO2 emissions may have offset growing season uptake in some years. They also indicated climate warming may reduce carbon uptake at Fish Island.
Treatment regimens in patients over 64 years with acute myeloid leukaemia: a retrospective single-institution, multi-site analysis
Creators: name: Sutter, Tabea
name: Schittenhelm, Marcus
name: Volken, Thomas
name: Lehmann, Thomas
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Medicine
Biological Sciences not elsewhere classified
Cancer
Science Policy
Hematology
Virology
Computational Biology

description: The aim of this study is to investigate the effect of treatment choice on survival, transfusion needs and hospitalizations in patients > 64 years old with newly diagnosed acute myeloid leukaemia (AML). This study retrospectively analysed patients over 64 years with AML diagnosed at a regional healthcare network in Switzerland between 2017 and 2020. Patients underwent four therapy groups: intensive chemotherapy (IC), hypomethylating agent in combination with the BCL2-Inhibitor venetoclax (HMA + VEN), hypomethylating agents alone (HMA) or best supportive care (BSC). Of 54 patients 12 (22%) were selected for IC, 13 (24%) for HMA + VEN, 17 (32%) for HMA and 12 (22%) for BSC. The median overall survival of the patients was 76 days, with a significant difference in the four therapy groups (IC 119 days, HMA + VEN 732 days, HMA monotherapy 73 days and BSC 12 days Log-Rank Test Chi2(2): p < 0.001). Patients with HMA + VEN spent significantly less time in the hospital 6.8 days/month compared to IC (19.5 days/month), HMA (20.5 days/month) and BSC (10.5 days/month) (p = 0.005). Transfusion needs were the highest in IC (7.0 RBC/month, 8.0 PC/month) (p = 0.023), whereas there was no difference between HMA + VEN (2.5 RBC/month, 3.2 PC/month), HMA monotherapy (5.3 RBC/month, 6.2 PC/month) and BSC (3.0 RBC/month, 1.4 PC/month). Our real-world data demonstrate superior OS rates of HMA + VEN when compared to IC, HMC or BSC, with a favourable side effect profile with regard to transfusion needs or hospitalization days. Abbreviations: AML, acute myeloid leukaemia; BCL2, B-cell leukaemia/lymphoma-2; BSC, best supportive care; CR, complete response; Cri, complete response with incomplete haematologic regeneration; FLT3, Fms Related Receptor Tyrosine Kinase 3; EKOS, Ethikkomission Ostschweiz; ELN, European Leukaemia Net; HMA, hypomethylating agent; IC, intensive chemotherapy; IDH, Isocitratdehydrogenase; LDAC, low-dose Cytarabine; NCCN, National Comprehensive Cancer Network; OS, overall survival; PC, platelet concentrate; RBC, red blood cell; RCT, randomized controlled trials; t-AML, therapy relative acute myeloid leukaemia'; VEN, venetoclax
Quasinormal modes of charged black holes in Asymptotically Safe Gravity
Creators: name: Dubinsky, Alexey
Publisher: name: arXiv
Year: 2024
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences
subject: G.1.2; F.1.1; I.2.1
subject: 83C57, 81T, 87A30

description: We calculate quasinormal modes of scalar and neutrino perturbations around the charged black hole in Asymptotically Safe Gravity. We show that the charge and coupling constant change the quasinormal spectrum considerably. We show that previous calculations of scalar quasinormal modes in this background [F. Javed, Phys. Dark Univ., 44, 101450 (2024)] suffer from a large numerical error exceeding the effect, that is, the deviations of the frequencies from their Schwarzschild limits. In the high frequency (eikonal) limit an explicit analytic formula for quasinormal modes is derived, which confirms the correspondence between the null circular geodesics and eikonal quasinormal frequencies.
Extremal Quantum Correlations and Cryptographic Security
Creators: name: Franz, T.
name: Furrer, F.
name: Werner, R. F.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We investigate a fundamental property of device independent security in quantum cryptography by characterizing probability distributions which are necessarily independent of the measurement results of any eavesdropper. We show that probability distributions that are secure in this sense are exactly the extremal quantum probability distributions. This allows us to give a characterization of security in algebraic terms. We apply the method to common examples for two-party as well as multi-party setups and present a scheme for verifying security of probability distributions with two parties, two measurement settings, and two outcomes.
description: 7 pages, 2 figures, revised version, accepted for publication in Phys. Rev. Lett
Additional file 1 of Artificial intelligence-supported lung cancer detection by multi-institutional readers with multi-vendor chest radiographs: a retrospective clinical validation study
Creators: name: Ueda, Daiju
name: Yamamoto, Akira
name: Shimazaki, Akitoshi
name: Walston, Shannon Leigh
name: Matsumoto, Toshimasa
name: Izumi, Nobuhiro
name: Tsukioka, Takuma
name: Komatsu, Hiroaki
name: Inoue, Hidetoshi
name: Kabata, Daijiro
name: Nishiyama, Noritoshi
name: Miki, Yukio
Publisher: name: figshare
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Additional File 1. Supplementary Methods, Comments, Tables, and Supplementary Figure Legends
Additional file 1 of The association mental health of adolescents with economic impact during the COVID-19 pandemic: a 2020 Korean nationally representative survey
Creators: name: Park, Hanul
name: Lee, Kang-Sook
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Appendix 1. General characteristics by depression and suicide ideation in the KYRBS 2020 adolescents. Appendix 2. General characteristics by unhappiness, lonely and stress in the KYRBS 2020 adolescents.
Three-slit experiments and quantum nonlocality
Creators: name: Niestegge, Gerd
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: An interesting link between two very different physical aspects of quantum mechanics is revealed; these are the absence of third-order interference and Tsirelson's bound for the nonlocal correlations. Considering multiple-slit experiments - not only the traditional configuration with two slits, but also configurations with three and more slits - Sorkin detected that third-order (and higher-order) interference is not possible in quantum mechanics. The EPR experiments show that quantum mechanics involves nonlocal correlations which are demonstrated in a violation of the Bell or CHSH inequality, but are still limited by a bound discovered by Tsirelson. It now turns out that Tsirelson's bound holds in a broad class of probabilistic theories provided that they rule out third-order interference. A major characteristic of this class is the existence of a reasonable calculus of conditional probability or, phrased more physically, of a reasonable model for the quantum measurement process.
description: 9 pages, no figure
Growth Law and Superuniversality in the Coarsening of Disordered Ferromagnets
Creators: name: Corberi, F.
name: Lippiello, E.
name: Mukherjee, A.
name: Puri, S.
name: Zannetti, M.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: We present comprehensive numerical results for domain growth in the two-dimensional {\it Random Bond Ising Model} (RBIM) with nonconserved Glauber kinetics. We characterize the evolution via the {\it domain growth law}, and two-time quantities like the {\it autocorrelation function} and {\it autoresponse function}. Our results clearly establish that the growth law shows a crossover from a pre-asymptotic regime with "power-law growth with a disorder-dependent exponent" to an asymptotic regime with "logarithmic growth". We compare this behavior with previous results on one-dimensional disordered systems and we propose a unifying picture in a renormalization group framework. We also study the corresponding crossover in the scaling functions for the two-time quantities. Super-universality is found not to hold. Clear evidence supporting the dimensionality dependence of the scaling exponent of the autoresponse function is obtained.
description: Thoroughly revised manuscript. The Introduction, Section 2 and Section 4 have been largely rewritten. References added. Final version accepted for publication on Journal of Statistical Mechanics: Theory and Experiment