cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Spin relaxation anisotropy in a GaAs quantum dot
Creators: name: Scarlino, P.
name: Kawakami, E.
name: Stano, P.
name: Shafiei, M.
name: Reichl, C.
name: Wegscheider, W.
name: Vandersypen, L. M. K.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We report that the electron spin relaxation time, T1, in a GaAs quantum dot with a spin-1/2 ground state has a 180 degree periodicity in the orientation of the in-plane magnetic field. This periodicity has been predicted for circular dots as due to the interplay of Rashba and Dresselhaus spin orbit contributions. Different from this prediction, we find that the extrema in the T1 do not occur when the magnetic field is along the [110] and [1-10] crystallographic directions. This deviation is attributed to an elliptical dot confining potential. The T1 varies by more than an order of magnitude when rotating a 3 Tesla field, reaching about 80 ms for the magic angle. We infer from the data that in our device the sign of the Rashba and Dresselhaus constants are opposite.
description: 8 pages, 8 figures
VINTERGATAN IV: Cosmic phases of star formation in Milky Way-like galaxies
Creators: name: Otero, Álvaro Segovia
name: Renaud, Florent
name: Agertz, Oscar
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The star formation history of a galaxy is modulated by a plethora of internal processes and environmental conditions. The details of how these evolve and couple together is not fully understood yet. In this work, we study the effects that galaxy mergers and morphological transformations have on setting different modes of star formation at galactic scales and across cosmic time. We monitor the global properties of VINTERGATAN, a 20 pc resolution cosmological zoom-in simulation of a Milky Way-type galaxy. Between redshifts 1 and 5, we find that major mergers trigger multiple starburst episodes, corresponding to a tenfold drop of the gas depletion time down to 100 Myr. Bursty star formation is enabled by the emergence of a galactic disc, when the rotational velocity of gas starts to dominate over its velocity dispersion. Coherent motions of gas then outweigh disordered ones, such that the galaxy responds to merger-induced forcings by redistributing large amounts of gas towards high densities. As a result, the overall star formation rate is enhanced with an associated decrease in the depletion time. Before redshift 5, mergers are expected to be even more frequent. However, a more turbulent interstellar medium, is incapable of reacting in such a collective manner so as to spark rapid star formation. Thus, a constant long depletion time of 1 Gyr is kept, along with a low, but gradually increasing star formation rate. After the last major merger at redshift 1, VINTERGATAN spends the next 8 Gyr evolving secularly. It has a settled and adiabatically growing disc, and a constant star formation rate with gas depletion times of 1-2 Gyr. Our results are compatible with the observed rapid transition between different modes of star formation when galaxies leave the main sequence.
description: 8 pages, accepted by MNRAS
Antitumor Agents 252. Application of validated QSAR models to database mining: discovery of novel tylophorine derivatives as potential anticancer agents
Creators: name: Bastow, Ken
name: Brossi, Arnold
name: Wei, Linyi
name: Tropsha, Alexander
name: Lee, Kuo-Hsiung
name: Zhang, Shuxing
name: Zheng, Weifan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: A combined approach of validated QSAR modeling and virtual screening was successfully applied to the discovery of novel tylophrine derivatives as anticancer agents. QSAR models have been initially developed for 52 chemically diverse phenanthrine-based tylophrine derivatives (PBTs) with known experimental EC50 using chemical topological descriptors (calculated with the MolConnZ program) and variable selection k nearest neighbor (kNN) method. Several validation protocols have been applied to achieve robust QSAR models. The original dataset was divided into multiple training and test sets, and the models were considered acceptable only if the leave-one-out cross-validated R2 (q2) values were greater than 0.5 for the training sets and the correlation coefficient R2 values were greater than 0.6 for the test sets. Furthermore, the q2 values for the actual dataset were shown to be significantly higher than those obtained for the same dataset with randomized target properties (Y-randomization test), indicating that models were statistically significant. Ten best models were then employed to mine a commercially available ChemDiv Database (ca. 500K compounds) resulting in 34 consensus hits with moderate to high predicted activities. Ten structurally diverse hits were experimentally tested and eight were confirmed active with the highest experimental EC50 of 1.8µM implying an exceptionally high hit rate (80%). The same ten models were further applied to predict EC50 for four new PBTs, and the correlation coefficient (R2) between the experimental and predicted EC50 for these compounds plus eight active consensus hits was shown to be as high as 0.57. Our studies suggest that the approach combining validated QSAR modeling and virtual screening could be successfully used as a general tool for the discovery of novel biologically active compounds.
Ligand and structure-based methodologies for the prediction of the activity of G protein-coupled receptor ligands
Creators: name: Tikhonova, Irina G.
name: Jacobson, Kenneth A.
name: Costanzi, Stefano
name: Harden, T. Kendall
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Accurate in silico models for the quantitative prediction of the activity of G protein-coupled receptor (GPCR) ligands would greatly facilitate the process of drug discovery and development. Several methodologies have been developed based on the properties of the ligands, the direct study of the receptor-ligand interactions, or a combination of both approaches. Ligand-based three-dimensional quantitative structure-activity relationships (3D-QSAR) techniques, not requiring knowledge of the receptor structure, have been historically the first to be applied to the prediction of the activity of GPCR ligands. They are generally endowed with robustness and good ranking ability; however they are highly dependent on training sets. Structure-based techniques generally do not provide the level of accuracy necessary to yield meaningful rankings when applied to GPCR homology models. However, they are essentially independent from training sets and have a sufficient level of accuracy to allow an effective discrimination between binders and nonbinders, thus qualifying as viable lead discovery tools. The combination of ligand and structure-based methodologies in the form of receptor-based 3D-QSAR and ligand and structure-based consensus models results in robust and accurate quantitative predictions. The contribution of the structure-based component to these combined approaches is expected to become more substantial and effective in the future, as more sophisticated scoring functions are developed and more detailed structural information on GPCRs is gathered.
title: Tadeusz Bigo o administracji i prawie administracyjnym – refleksje wrocławskiej szkoły administratywistycznej
Creators: name: Kocowski, Tadeusz
name: Lisowski, Piotr
name: Paplicki, Mateusz
Publisher: name: E-Wydawnictwo. Prawnicza i Ekonomiczna Biblioteka Cyfrowa. Wydział Prawa, Administracji i Ekonomii Uniwersytetu Wrocławskiego
Year: 2020

description: Jubileuszowe konotacje (w 2019 r. minęło 50 lat od utworzenia na ówczesnym Wydziale Prawa Uniwersytetu Wrocławskiego Instytutu Nauk Administracyjnych, z kolei w 2020 r. wrocławski Wydział Prawa, Administracji i Ekonomii świętuje 75 lat istnienia) dały impuls do przygotowania publikacji analizującej ze współczesnej perspektywy poglądy doktrynalne ojca założyciela wrocławskiej szkoły administratywistycznej – zawarte w publikacji z 1948 r. pt.Prawo administracyjne. Część I. Instytucje ogólne (opracowanej przez dr. W. Kawkę na podstawie wykładów uniwersyteckich prof. dr. T. Bigo). Zasadniczą część tego jubileuszowo-rocznicowego wydawnictwa (w dniu 1 września 2020 r. minęła też 45. rocznica śmierci Profesora Tadeusza Bigo) stanowią refleksje pracowników Instytutu Nauk Administracyjnych Wydziału Prawa, Administracji i Ekonomii Uniwersytetu Wrocławskiego, dla których punkt wyjścia stanowiły poglądy Profesora przedstawione w opublikowanym 72 lata temu podręczniku.
title: Urban policy impact evaluation : towards a systematic approach.
Creators: name: H. Bakr, Ashraf
Publisher: name: University of Liverpool Repository
Year: 2023

description: The main objective of this research is to develop a systematic approach for comprehensive ex-post evaluation of urban policy. In broad terms, urban policies are central government initiatives applied in a spatially targeted manner within urban areas where specific needs have been identified. 'Comprehensive' is defined as the attempt to answer all the questions policy-makers and stakeholders are likely to raise at the various stages of the planning and implementation process. In moving towards the achievement of this objective a number of different, yet supplementary, sources of knowledge and experience are examined. Part 1 reviews the underlying assumptions and strengths and weaknesses of existing appraisal methods and examines their applicability in ex-post evaluation and the choice among them. It also examines the different views and models of both monitoring and implementation analysis and the role each can play within a comprehensive evaluation approach. Part 2 examines evaluation methods adopted in a number of case studies in various fields. It starts with the first hand experience in urban policy evaluation within a governmental context. Then, it critically reviews the methodology adopted for evaluation in a number of case studies in the field of urban policy. Evaluation traditions in the fields of regional (economic) policy in Britain and, trunk road and motorway schemes in the UK, USA and the Netherlands are also reviewed. These different strands are brought together in the form of a flexible systematic approach for comprehensive ex-post evaluation of urban policy. The choice of the 'components' of the approach is based, to a large extent, on the first part of the research. However, the organisation of the approach and the exact role each tool can play are greatly informed by the second part.
Sub-recoil clock-transition laser cooling enabling shallow optical lattice clocks
Creators: name: Zhang, X.
name: Beloy, K.
name: Hassan, Y. S.
name: McGrew, W. F.
name: Chen, C-C
name: Siegel, J. L.
name: Grogan, T.
name: Ludlow, A. D.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: Laser cooling is a key ingredient for quantum control of atomic systems in a variety of settings. In divalent atoms, two-stage Doppler cooling is typically used to bring atoms to the uK regime. Here, we implement a pulsed radial cooling scheme using the ultranarrow 1S0-3P0 clock transition in ytterbium to realize sub-recoil temperatures, down to tens of nK. Together with sideband cooling along the one-dimensional lattice axis, we efficiently prepare atoms in shallow lattices at an energy of 6 lattice recoils. Under these conditions key limits on lattice clock accuracy and instability are reduced, opening the door to dramatic improvements. Furthermore, tunneling shifts in the shallow lattice do not compromise clock accuracy at the 10-19 level.
Probing Strange Stars with Advanced Gravitational Wave Detectors
Creators: name: Moraes, P. H. R. S.
name: Miranda, O. D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: When a neutron star is compressed to huge densities, it may be converted to a strange star. In property of the event/year rate of a neutron star - strange star binary system, we show that the operational phase of advanced gravitational wave detectors may bring up some evidences that such strange stars do exist. Moreover we argue that such a system could be a plausible progenitor to GRB 051103 and GRB 070201, whose non-detection by LIGO last run awaits convincing explanation.
description: Accepted for publication in MNRAS Letters
Lattice Monte Carlo Simulations with Two Impurity Worldlines
Creators: name: Hildenbrand, Fabian
name: Elhatisari, Serdar
name: Lähde, Timo A.
name: Lee, Dean
name: Meißner, Ulf-G.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: We develop the impurity lattice Monte Carlo formalism, for the case of two distinguishable impurities in a bath of polarized fermions. The majority particles are treated as explicit degrees of freedom, while the impurities are described by worldlines. The latter serve as localized auxiliary fields, which affect the majority particles. We apply the method to non-relativistic three-dimensional systems of two impurities and a number of majority particles where both the impurity-impurity interaction and the impurity-majority interaction have zero range. We consider the case of an attractive impurity-majority interaction, and we study the formation and disintegration of bound states as a function of the impurity-impurity interaction strength. We also discuss the potential applications of this formalism to other quantum many-body systems.
description: 7 pages, 4 figures
Transgenerationale Traumatisierung in der Sozialen Arbeit: Eine Forschungsarbeit zu Handlungsweisen von Kindesbeistandspersonen bei Kindern und Jugendlichen in Familiensystemen
Creators: name: Walz, Laura
Publisher: name: Hochschule Luzern – Soziale Arbeit
Year: 2024

description: Die transgenerationale Traumatisierung gewinnt in der Sozialen Arbeit zunehmend an Bedeutung. Sie beschreibt die Übertragung von Traumata und belastenden Erfahrungen von einer Generation auf die nächste innerhalb von Familien, was das Wohlbefinden von Kindern und Jugendlichen beeinflussen kann. Kindesbeistandspersonen spielen eine wichtige Rolle im Schutz und der Unterstützung von Kindern und Jugendlichen in familiären Krisensituationen. Sie sind verantwortlich für die Beurteilung möglicher Kindeswohlgefährdung, die Entwicklung von Interventionsplänen und die Sicherstellung, dass die Bedürfnisse der betroffenen Kinder und Jugendlichen angemessen berücksichtigt werden.

Diese Bachelorarbeit untersucht das Thema «Soziale Arbeit und transgenerationale Traumatisierung» mit dem Schwerpunkt auf dem Umgang von Kindesbeistandspersonen mit betroffenen Kindern, Jugendlichen und deren Familien. Ziel ist es, zu verstehen, wie sie Familien unterstützen können, in denen dieses Phänomen eine Rolle spielt, und praktische Einblicke sowie Empfehlungen für ihre Arbeit zu entwickeln. Es wird ein qualitatives Forschungsdesign angewendet, welches leitfadengestützte Expert:inneninterviews zur Datenerhebung verwendet. Die Datenauswertung orientiert sich am pragmatischen Auswertungsverfahren nach Mühlfeld et al. (1981). 

Die Erkenntnisse dieser Arbeit sollen die Bedeutung transgenerationaler Traumatisierung für Sozialarbeitende im Kontext der Kindesbeistandschaft aufzeigen und die Qualität der Unterstützung und Interventionen für betroffene Kinder und Jugendliche verbessern.
description: + Code Diss LU: hslusa basa be + Fussnote: Bachelor-Arbeit, Hochschule Luzern – Soziale Arbeit, Studienrichtung Sozialarbeit, 2024 + NL-Code: NLLUHSA202409
Inverted level populations of hydrogen atoms in ionized gas
Creators: name: Zhu, Feng-Yao
name: Wang, Junzhi
name: Zhu, Qing-Feng
name: Zhang, Jiang-Shui
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Context. Level population inversion of hydrogen atoms in ionized gas may lead to stimulated emission of hydrogen recombination lines, and the level populations can in turn be affected by powerful stimulated emissions. Aims. In this work the interaction of the radiation fields and the level population inversion of hydrogen atoms is studied. The effect of the stimulated emissions on the line profiles is also investigated. Methods. Our previous nl-model for calculating level populations of hydrogen atoms and hydrogen recombination lines is improved. The effects of line and continuum radiation fields on the level populations are considered in the improved model. By using this method the properties of simulated hydrogen recombination lines and level populations are used in analyses. Results. The simulations show that hydrogen radio recombination lines are often emitted from the energy level with an inverted population. The widths of Hn$α$ lines can be significantly narrowed by strong stimulated emissions to be even less than 10 km s$^{-1}$. The amplification of hydrogen recombination lines is more affected by the line optical depth than by the total optical depth. The influence of stimulated emission on the estimates of electron temperature and density of ionized gas is evaluated. We find that comparing multiple line-to-continuum ratios is a reliable method for estimating the electron temperature, while the effectiveness of the estimation of electron density is determined by the relative significance of stimulated emission.
description: Accepted for published in A&A. 25 pages, 13 figures
title: Rural South West Lancashire in the eighteenth century : the land and the people
Creators: name: Malcolm. Virgoe, John
Publisher: name: University of Liverpool Repository
Year: 2023

description: This thesis sets out to examine the rural communities of south west Lancashire in the eighteenth century, and their response to the important changes taking place at that time in the surrounding area. Rural south west Lancashire in the eighteenth century was an area of small farms and conservative farmers who made a satisfactory living from a few acres by production of niche products such as vegetables, potatoes and cheese for the increasing markets of the nearby growing towns. Most farms also produced small amounts of cereals, predominantly oats, probably for domestic consumption on the farm by the family, and livestock. Such farms required little capital investment, and in terms of their overall wealth their farmers were poorer than their contemporaries in the com-growing areas, but in terms of savings and investment in household goods ( indicative of lifestyle), they could not be considered impoverished. Farm labour was mainly provided by the family, supplemented by casual labour supplied by neighbours. There were a number of important, eighteenth century local landowners who were far-sighted in appreciating the importance of growing markets and made considerable financial investments in land reclamation, and establishing a progressive attitude to agricultural change. Eighteenth century farming in the area was not backward, but was different from that in the areas usually considered progressive, such as East Anglia, and had more in common with the reclaimed lands of the Low Countries. The eighteenth century laid the foundations for south west Lancashire to become an important vegetable-growing area in the twentieth century. Eighteenth century society in the area was remarkably stable, a situation sustained by the persistence of leasing for lives until the end of the century, and a form of partible inheritance. Community life was only partly based upon the township, and many people lived their lives within the ambit of the district and could be considered to form a south west Lancashire community. The late eighteenth century landscape was a landscape in transition. It comprised a mixture of old, small enclosures, and new, reclaimed, mosslands with larger fields bounded not by hedges but by ditches; a mixture of dilapidated, timberframed thatched buildings, and new, mainly stone-built and flag-roofed yeomen's houses. The thesis shows eighteenth century south west Lancashire to be an area which, whilst influenced by the economic and social changes in the surrounding county, yet retained its distinctive character.
Design, synthesis and experimental validation of novel potential chemopreventive agents using random forest and support vector machine binary classifiers
Creators: name: Sedykh, Alexander
name: Zhu, Hao
name: Zhang, Liying
name: Lee, Kuo-Hsiung
name: Tokuda, Harukuni
name: Kim, Marlene T.
name: Sprague, Brienne
name: Ichiishi, Eiichiro
name: Shi, Qian
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Compared to the current knowledge on cancer chemotherapeutic agents, only limited information is available on the ability of organic compounds, such as drugs and/or natural products, to prevent or delay the onset of cancer. In order to evaluate chemical chemopreventive potentials and design novel chemopreventive agents with low to no toxicity, we developed predictive computational models for chemopreventive agents in this study. First, we curated a database containing over 400 organic compounds with known chemoprevention activities. Based on this database, various random forest and support vector machine binary classifiers were developed. All of the resulting models were validated by cross validation procedures. Then, the validated models were applied to virtually screen a chemical library containing around 23,000 natural products and derivatives. We selected a list of 148 novel chemopreventive compounds based on the consensus prediction of all validated models. We further analyzed the predicted active compounds by their ease of organic synthesis. Finally, 18 compounds were synthesized and experimentally validated for their chemopreventive activity. The experimental validation results paralleled the cross validation results, demonstrating the utility of the developed models. The predictive models developed in this study can be applied to virtually screen other chemical libraries to identify novel lead compounds for the chemo-prevention of cancers.
Dense non-aqueous phase liquids at former manufactured gas plants: Challenges to modeling and remediation
Creators: name: Miller, C.T.
name: Birak, P.S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The remediation of dense non-aqueous phase liquids (DNAPLs) in porous media continues to be one of the most challenging problems facing environmental scientists and engineers. Of all the environmentally relevant DNAPLs, tars in the subsurface at former manufactured gas plants (FMGP’s) pose one of the biggest challenges due to their complex chemical composition and tendency to alter wettability. To further our understanding of these complex materials, we consulted historic documentation to evaluate the impact of gas manufacturing on the composition and physicochemical nature of the resulting tars. In the recent literature, most work to date has been focused in a relatively narrow portion of the expected range of tar materials, which has yielded a bias toward samples of relatively low viscosity and density. In this work, we consider the dissolution and movement of tars in the subsurface, models used to predict these phenomena, and approaches used for remediation. We also explore the open issues and detail important gaps in our fundamental understanding of these extraordinarily complex systems that must be resolved to reach a mature level of understanding.
Detailed analysis of the curvature bounce: background dynamics and imprints in the CMB
Creators: name: Renevey, Cyril
name: Barrau, Aurélien
name: Martineau, Killian
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: If the spatial sections of the Universe are positively curved, extrapolating the inflationary stage backward in time inevitably leads to a classical bounce. This simple scenario, non-singular and free of exotic physics, deserves to be investigated in details. The background dynamics exhibits interesting features and is shown to be mostly insensitive to initial conditions as long as observational consequences are considered. The primordial scalar power spectrum is explicitly computed, for different inflaton potentials, and the subsequent CMB temperature anisotropies are calculated. The results are compatible with current measurements. Some deviations with respect to the standard paradigm can however appear at large scales and we carefully disentangle what is associated with the vacuum choice with what is more fundamentally due to the bounce itself.
Co-existing structures in 105Ru
Creators: name: Lalkovski, S.
name: Ivanova, D.
name: Stefanova, E. A.
name: Korichi, A.
name: Petkov, P.
name: Kownacki, J.
name: Kutsarova, T.
name: Minkova, A.
name: Bazzacco, D.
name: Bergstrom, M.
name: Gorgen, A.
name: Herskind, B.
name: Hubel, H.
name: Jansen, A.
name: Kisyov, S.
name: Khoo, T. L.
name: Kondev, F. G.
name: Lopez-Martens, A.
name: Podolyak, Zs.
name: Schonwasser, G.
name: Yordanov, O.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: New positive-parity states, having a band-like structure, were observed in 105Ru. The nucleus was produced in induced fission reaction and the prompt gamma-rays, emitted from the fragments, were detected by the EUROBALL III multi-detector array. The partial scheme of excited 105Ru levels is analyzed within the Triaxial-Rotor-plus-Particle approach.
Circle-invariant fat bundles and symplectic Fano 6-manifolds
Creators: name: Fine, Joel
name: Panov, Dmitri
Publisher: name: arXiv
Year: 2014
Subjects: subject: Differential Geometry (math.DG)
subject: Symplectic Geometry (math.SG)
subject: FOS: Mathematics

description: We prove that a compact 4-manifold which supports a circle-invariant fat SO(3)-bundle is diffeomorphic to either S^4 or CP^2-bar. The proof involves studying the resulting Hamiltonian circle action on an associated symplectic 6-manifold. Applying our result to the twistor bundle of Riemannian 4-manifolds shows that S^4 and CP^2-bar are the only 4-manifolds admitting circle-invariant metrics solving a certain curvature inequality. This can be seen as an analogue of Hsiang-Kliener's theorem that only S^4 and CP^2 admit circle-invariant metrics of positive sectional curvature.
description: 26 pages
Schutzkonzepte in Pflegefamilien: Potentiale und Herausforderungen einer konzeptuellen Verankerung des Schutzes von Pflegekindern und Schlussfolgerungen für die Soziale Arbeit
Creators: name: Sutter, Rahel
Publisher: name: Hochschule Luzern – Soziale Arbeit
Year: 2024

description: In der vorliegenden Bachelorarbeit befasst sich die Autorin Rahel Sutter mit der Frage, warum es in Pflegefamilien Schutzkonzepte braucht und welche Anforderungen diese erfüllen sollen. Mithilfe von Werken aus der Fachliteratur werden die Herausforderungen im Pflegekinderwesen, aufgrund derer der Schutz von Pflegekindern gefährdet werden kann, sowie der Nutzen von Schutzkonzepten im Hinblick auf diese Herausforderungen aufgezeigt. Zudem wurde mit leitfadengestützten Interviews untersucht, welche Bedeutung Schutzkonzepte für die Akteur*innen im Pflegekinderwesen haben und welche Anforderungen diese Akteur*innen an die Schutzkonzepte in Pflegefamilien stellen.

Anhand der Ergebnisse aus der Fachliteraturrecherche und der empirischen Untersuchung wird aufgezeigt, dass sich die Schutzkonzepte in Pflegefamilien nicht nur auf den Schutz der Pflegekinder beziehen, sondern auch Pflegeeltern Sicherheit bieten können. Die Konzeption von unterschiedlichen Massnahmen zur Erkennung, Prävention und Intervention von Gefährdungssituationen der Pflegekinder, zur Unterstützung von Pflegeeltern in Belastungssituationen sowie abgestimmte Verfahren bei Grenzverletzungen an Pflegekindern zählen zu den Anforderungen an ein Schutzkonzept in Pflegefamilien. Die Ergebnisse aus den Befragungen von Akteur*innen des Pflegekinderwesens zeigen auf, dass sie Schutzkonzepte in Pflegefamilien befürworten. Die Umsetzung von Schutzkonzepten kann jedoch aufgrund der Privatheit, welche Pflegefamilien aufweisen, zur Herausforderung werden. Zudem bedarf die Umsetzung von Schutzkonzepten einer professionellen Begleitung, welche in unbegleiteten Pflegeverhältnissen nur erschwert geleistet werden kann.
description: + Code Diss LU: hslusa basp be + Fussnote: Bachelor-Arbeit, Hochschule Luzern – Soziale Arbeit, Studienrichtung Sozialpädagogik, 2024 + NL-Code: NLLUHSA202409
Dense, viscous brine behavior in heterogeneous porous medium systems
Creators: name: Gasda, S.E.
name: Farthing, M.W.
name: Knight, S.R.
name: Wright, D. Johnson
name: Brubaker, G.R.
name: Miller, C.T.
name: Pedit, J.A.
name: Murphy, L.L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The behavior of dense, viscous calcium bromide brine solutions used to remediate systems contaminated with dense nonaqueous phase liquids (DNAPLs) is considered in laboratory and field porous medium systems. The density and viscosity of brine solutions are experimentally investigated and functional forms fit over a wide range of mass fractions. A density of 1.7 times, and a corresponding viscosity of 6.3 times, that of water is obtained at a calcium bromide mass fraction of 0.53. A three-dimensional laboratory cell is used to investigate the establishment, persistence, and rate of removal of a stratified dense brine layer in a controlled system. Results from a field-scale experiment performed at the Dover National Test Site are used to investigate the ability to establish and maintain a dense brine layer as a component of a DNAPL recovery strategy, and to recover the brine at sufficiently high mass fractions to support the economical reuse of the brine. The results of both laboratory and field experiments show that a dense brine layer can be established, maintained, and recovered to a significant extent. Regions of unstable density profiles are shown to develop and persist in the field-scale experiment, which we attribute to regions of low hydraulic conductivity. The saturated-unsaturated, variable-density ground-water flow simulation code SUTRA is modified to describe the system of interest, and used to compare simulations to experimental observations and to investigate certain unobserved aspects of these complex systems. The model results show that the standard model formulation is not appropriate for capturing the behavior of sharp density gradients observed during the dense brine experiments.
Cosolvent flushing for the remediation of PAHs from former manufactured gas plants
Creators: name: Aitken, M.D.
name: Hauswirth, S.C.
name: Schultz Birak, P.
name: Pedit, J.A.
name: Newman, A.P.
name: Richardson, S.D.
name: Miller, C.T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Cosolvent flushing is a technique that has been proposed for the removal of hydrophobic organic contaminants in the subsurface. Cosolvents have been shown to dramatically increase the solubility of such compounds compared to the aqueous solubility; however, limited data are available on the effectiveness of cosolvents for field-contaminated media. In this work, we examine cosolvent flushing for the removal of polycyclic aromatic hydrocarbons (PAHs) in soil from a former manufactured gas plant (FMGP). Batch studies confirmed that the relationship between the soil-cosolvent partitioning coefficient (Ki) and the volume fraction of cosolvent (fc) followed a standard log-linear equation. Using methanol at an fc of 0.95, column studies were conducted at varying length scales, ranging from 11.9 to 110 cm. Removal of PAH compounds was determined as a function of pore volumes (PVs) of cosolvent flushed. Despite using a high fc, rate and chromatographic effects were observed in all the columns. PAH effluent concentrations were modeled using a common two-site sorption model. Model fits were improved by using MeOH breakthrough curves to determine fitted dispersion coefficients. Fitted mass-transfer rates were two to three orders of magnitude lower than predicted values based on published data using artificially contaminated sands.
Distributions of gas and small and large grains in the LkH$α\,330$ disk trace a young planetary system
Creators: name: Pinilla, P.
name: Benisty, M.
name: Kurtovic, N. T.
name: Bae, J.
name: Dong, R.
name: Zhu, Z.
name: Andrews, S.
name: Carpenter, J.
name: Ginski, C.
name: Huang, J.
name: Isella, A.
name: Pérez, L.
name: Ricci, L.
name: Rosotti, G.
name: Villenave, M.
name: Wilner, D.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: [abridged] We present new scattered light and millimeter observations of the protoplanetary disk around LkH$α\,330$, using SPHERE/VLT and ALMA, respectively. The scattered-light SPHERE observations reveal an asymmetric ring at around 45au from the star in addition to two spiral arms with similar radial launching points at around 90au. The millimeter observations from ALMA (resolution of 0.06''$\times$0.04'') mainly show an asymmetric ring located at 110au from the star. In addition to this asymmetry, there are two faint symmetric rings at 60au and 200au. The $^{12}$CO, $^{13}$CO, and C$^{18}$O lines seem to be less abundant in the inner disk (these observations have a resolution of 0.16''$\times$0.11''). The $^{13}$CO peaks at a location similar to the inner ring observed with SPHERE, suggesting that this line is optically thick and traces variations of disk temperature instead of gas surface-density variations, while the C$^{18}$O peaks slightly further away at around 60au. We compare our observations with hydrodynamical simulations that include gas and dust evolution, and conclude that a 10$M_{\rm{Jup}}$ mass planet at 60au and in an eccentric orbit ($e=0.1$) can qualitatively explain most of the observed structures. A planet in a circular orbit leads to a much narrower concentration in the millimeter emission, while a planet in a more eccentric orbit leads to a very eccentric cavity as well. In addition, the outer spiral arm launched by the planet changes its pitch angle along the spiral due to the eccentricity and when it interacts with the vortex, potentially appearing in observations as two distinct spirals. Our observations and models show that LkH$α\,330$ is an interesting target to search for (eccentric-) planets while they are still embedded in their parental disk, making it an excellent candidate for studies on planet-disk interaction.
description: Accepted for publication in A&A, minor changes after language edition
Improved systemic pharmacokinetics, biodistribution, and antitumor activity of CpG oligodeoxynucleotides complexed to endogenous antibodies in vivo
Creators: name: Palma, Enzo
name: Cho, Moo J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: CpG oligodeoxynucleotides (CpG-ODNs) fail to elicit antitumor immunity after intravenous administration presumably due to their rapid renal clearance and low tumor accumulation. To address this issue, we tested the hypothesis that endogenous IgG can be used as systemic drug carriers to improve the pharmacokinetics, tumor accumulation, and antitumor activity of intravenously administered CpG-ODNs. To this end, tritium-labeled CpG-ODNs conjugated with one or two dinitrophenyl (DNP) haptens (DNP- and DNP2-[3H]-CpG-ODN) were intravenously dosed into DNP-immunized Balb/c mice bearing subcutaneous CT26 colorectal tumors. Serum and tissue samples for pharmacokinetic and biodistribution profiling were collected at predetermined timepoints and analyzed by liquid scintillation. In antitumor efficacy studies, DNP-immunized, CT26 tumor-bearing mice were intravenously dosed with PBS, CpG-ODN, or DNP-CpG-ODN every five days. Tumor volumes and macroscopic and histological examination of resected solid tumors were used to quantitatively and qualitatively assess tumor growth inhibition. Relative to [3H]-CpG-ODN, dinitrophenylated [3H]-CpG-ODNs displayed substantial increases in systemic exposure (900–1650 fold) and half-life (100–300 fold), marked decreases in systemic clearance (750–1500 fold) and volume of tissue distribution (13–37 fold), as well as substantial and sustained tumor accumulation (~30% vs. <2% injected dose/g). Antitumor efficacy studies demonstrated that DNP-CpG-ODN inhibited tumor growth by up to 60% relative to PBS control whereas CpG-ODN treatment had no apparent effect. Macroscopic and histological examination of harvested tumors at various timepoints revealed the presence of regions of necrotic tissue only in tumors from mice treated with DNP-CpG-ODN. Collectively, these results show the potential of endogenous IgG to mediate the systemic delivery of CpG-ODN to solid tumors and to enhance their antitumor activity following intravenous administration.
Accretion and outflow in the proplyd-like objects near Cygnus OB2
Creators: name: Guarcello, M. G.
name: Drake, J. J.
name: Wright, N. J.
name: Garcìa-Alvarez, D.
name: Kraemer, K. E.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Cygnus OB2 is the most massive association within 2kpc from the Sun, hosting hundreds of massive stars, thousands of young low mass members, and some sights of active star formation in the surrounding cloud. Recently, 10 photoevaporating proplyd-like objects with tadpole-shaped morphology were discovered in the outskirts of the OB association, approximately 6-14pc away from its center. The classification of these objects is ambiguous, being either evaporating residuals of the parental cloud which are hosting a protostar inside, or disk-bearing stars with an evaporating disk, such as the evaporating proplyds observed in the Trapezium Cluster in Orion. In this paper we present a study based on low resolution optical spectroscopic observations made with the Optical System for Imaging and low Resolution Integrated Spectroscopy (OSIRIS), mounted on the 10.4m Gran Telescopio CANARIAS (GTC), of two of these protostars. The spectrum of one of the objects shows evidence of accretion but not of outflows. In the latter object, the spectra show several emission lines indicating the presence of an actively accreting disk with outflow. We present estimates of the mass loss rate and the accretion rate from the disk, showing that the former exceeds the latter as observed in other known objects with evaporating disks. We also show evidence of a strong variability in the integrated flux observed in these objects, as well as in the accretion and outflow diagnostics.
description: Accepted in ApJ
An efficient and low immunostimulatory nanoparticle formulation for systemic siRNA delivery to the tumor
Creators: name: Li, Shyh-Dar
name: Huang, Leaf
name: Conwell, Christine C.
name: Chono, Sumio
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: We have developed a nanoparticle formulation [liposomes-protamine-hyaluronic acid nanoparticle (LPH-NP)] for systemically delivering siRNA into the tumor. The LPH-NP was prepared in a self-assembling process. Briefly, protamine and a mixture of siRNA and hyaluronic acid were mixed to prepare a negatively charged complex. Then, cationic liposomes were added to coat the complex with lipids via charge-charge interaction to prepare the LPH-NP. The LPH-NP was further modified by DSPE-PEG or DSPE-PEG-anisamide by the post-insertion method. Anisamide is a targeting ligand for the sigma receptor over-expressed in the B16F10 melanoma cells. The particle size, zeta potential and siRNA encapsulation efficiency of the formulation were approximately 115 nm, +25 mV and 90%, respectively. Luciferase siRNA was used to evaluate the gene silencing activity in the B16F10 cells, which were stably transduced with a luciferase gene. The targeted LPH-NP (PEGylated with ligand) silenced 80% of luciferase activity in the metastatic B16F10 tumor in the lung after a single i.v. injection (0.15 mg siRNA/kg). The targeted LPH-NP also showed very little immunotoxicity in a wide dose range (0.15 – 1.2 mg siRNA/kg), while the previously published formulation, LPD-NP (liposome-protamine-DNA nanoparticle), had a much narrow therapeutic window (0.15–0.45 mg/kg).
Obsesif Kompulsif Bozukluk ve Kabul ve Kararlılık Terapisi Üzerine Sistematik Derleme
Creators: name: KAYMAKLILI, Sunagül
name: KARAAZİZ, Meryem
Publisher: name: Zenodo
Year: 2024

description: Bu derleme çalışmasının amacı Obsesif Kompulsif Bozukluk yaşayan bireylerde Kabul ve Kararlılık Terapisinin kullanımını incelemektir. Yapılan bu çalışmada sistematik derleme yöntemi kullanılmış olup saha çalışması ya da herhangi bir ölçek kullanılmamıştır. Sadece İngilizce dilinde ele alınan çalışmalar 2010-2023 yılları arasındadır. Bu çalışmalar randomize kontrollü çalışmalardan oluşmaktadır. Bu derleme çalışması Şubat 2024 ve Mayıs 2024 olmak üzere iki aşamada gerçekleşmiştir. Yapılan literatür taraması sonucunda altı çalışma ele alınmıştır. Ele alınan bu altı çalışma sonucunda Kabul ve Kararlılık Terapisinin Obsesif Kompulsif Bozukluğu olan kişilerde belirtileri azalttığı, yaşam kalitesini arttırdığı ve önemli derecede iyileştirmeler yaptığı görülmektedir.
Methods and algorithms for behavioral modeling of ferrite power inductors
Creators: name: Stoyka, Kateryna
Publisher: name: Universita degli studi di Salerno
Year: 2019
Subjects: subject: ING-INF/04 AUTOMATICA
subject: Inductors
subject: Modeling
subject: Algorithms

description: 2017 - 2018
description: Information technology allows solving numerous problems regarding all the aspects of everyday life, including technical activities related to the design of devices and systems. In the electronic eld, di erent types of softwares are widely used to support designers in solving the problems of electronic cir- cuit design, at device level and system level. Power electronics is one of the most important modern technologies, since power supply systems are used to feed any electric and electronic device and system in manifold applications (e.g. computers, automotive, aerospace, consumer electronics, etc). Switch- ing power supply design is mostly driven by high e ciency and high reliability requirements. The strong non linearity of switching power supplies and the di culty of application of advanced design methodologies often push design- ers to adopt a conservative approach, based on simpli ed robust and reliable methods. This mostly result in sub-optimal design solutions characterized by components oversizing. This dissertation discusses innovative applications of enhanced numerical techniques and intelligent algorithms to power supplies optimization and design. The impact of innovative modeling and computing techniques in the discovery of novel advanced solutions outperforming the traditional conservative designs is emphasized. Power electronics is ever moving towards higher e ciency and higher power density. Magnetic components | inductors and transformers | oc- cupy a signi cant amount of space in today's Switch-Mode Power Supplies (SMPSs), and furthermore, considerable losses occur in these components. In order to achieve a higher level of miniaturization, reduction in the size of these components is crucial. Ferrite Power Inductors (FPIs) are usually the rst choice for high-e ciency designs of SMPS, thanks to their resulting low losses. However, FPIs su er of a pretty sharp inductance drop when their current exceeds a certain threshold, occurring due to the saturation of their magnetic 2 core. In SMPS design, it is commonly considered a good practice to select FPIs operating in the region of weak saturation (within about 20% inductance drop). This limitation is due to the lack of methods for quick prediction of real impact of FPIs saturation in SPMS applications. The consequence of the adoption of such conventional design approach is that inductors are often oversized. … [edited by Author]
The New Perspectives of Motherhood Advances In India: Maternity Benefit Act
Creators: name: Disha S Tiwari
name: Adv Dr Mannalal Pandiya
Publisher: name: Zenodo
Year: 2022

description: Abstract In the patriarchal society women is said to be the multi tasker in all the field there are many right and fundamental duties that is given to them. In a reformist civilization , it has been gradually realized that women end to end with the men play a protagonist performance in making the nation flourish and as well as raising the financial economic of country . There has been a substantiation of tremendous revolution in the status of women with increasing their engagement in labour market, even though the leaning towards their social protection and social security is still under the certainty and disappointing. The usual occurrence behind this mentality of the society is the opinion of women as housewives, caregivers, mothers, and secondary sources of household activities. But now the time has come to change this traditional perception of the society. The government of India, to ensure gender impartiality has passed number of legislations which provide employment benefits such as wage benefits, better working conditions, maternity benefits and social security. Maternity benefits act as organizer which believed to create an environment that assist and improve a women worker’s capability to maintain balance in work and family engagements
High-accuracy Rb$_{2}^+$ interaction potentials based on coupled cluster calculations
Creators: name: Schnabel, Jan
name: Cheng, Lan
name: Köhn, Andreas
Publisher: name: arXiv
Year: 2022
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: This work discusses a protocol for constructing highly accurate potential energy curves (PECs) for the lowest two states of Rb$_{2}^+$, i.e. $X\,{}^2Σ{_g^+}$ and $(1) {}^2Σ{_u^+}$, using an additivity scheme based on coupled-cluster theory. The approach exploits the findings of our previous work [J. Schnabel, L. Cheng and A. Köhn, J. Chem. Phys. 155, 124101 (2021)] to avoid the unphysical repulsive long-range barrier occurring for symmetric molecular ions when perturbative estimates of higher-order cluster operators are employed. Furthermore, care was taken to reproduce the physically correct exchange splitting of the $X {}^2Σ{_g^+}$ and $(1) {}^2Σ{_u^+}$ PECs. The accuracy of our computational approach is benchmarked for ionization energies of Rb and for spectroscopic constants as well as vibrational levels of the $a {}^3Σ{_u^+}$ triplet state of Rb\textsubscript{2}. We study high-level correlation contributions, high-level relativistic effects and inner-shell correlation contributions and find very good agreement with experimental reference values for the atomic ionization potential and the binding energy of Rb$_{2}$ in the $a\,{}^3Σ{_u^+}$ triplet state. Our final best estimate for the binding energy of the Rb$_{2}^+$ $X {}^2Σ{_g^+}$ state including zero-point vibrational contributions is $D_0 = 6179\,\mathrm{cm}^{-1}$ with an estimated error bound of $\mathcal{O}(\pm 30\,\mathrm{cm}^{-1})$. This value is smaller than the experimentally inferred lower bond of $D_0\ge 6307.5\,\mathrm{cm}^{-1}$ [Bellos et al., Phys. Rev. A 87, 012508 (2013)] and will require further investigation. For the $(1) {}^2Σ{_u^+}$ state a shallow potential with $D_0 = 78.4\,\mathrm{cm}^{-1}$ and an error bound of $\pm 9\,\mathrm{cm}^{-1}$ is computed.