cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Biorecognizable polymer conjugates containing 5-fluorouracil for the treatment of colon cancer
Creators: name: Putnam, David Aaron
Publisher: name: University of Utah
Year: 2012
Subjects: Cancer
Chemotherapy

description: Biorecognizable polymer conjugates containing the anticancer compound, 5-fluorouracil, have the potential to increase the anticancer activity and decrease the non-specific toxicity of the parent drug. This research was conducted to evaluate the anticancer activity of biorecognizable polymer conjugates containing 5-fluorouracil based on N-(2-hydroxypropyl)methacrylamide (HPMA) toward colon cancer. The term 'biorecognizable' means that entities present either on the cell surface, such as receptors, or intracellularly, such as enzymes, can interact with the polymer conjugate to impart targetability to the conjugate or to control the intracellular release of the drug from the conjugate. The first half of the research was designed to evaluate the intracellular biorecognition of polymer conjugates containing various oligopeptide side chains terminated with a derivative of 5-fluorouracil. Polymer conjugates possessing 5-fluorouracil terminated oligopeptide side chains of varying lengths and compositions were synthesized and incubated with lysosomal enzymes to determine the effect of chain length and composition upon the enzymatically catalyzed release of 5-fluorouracil. The results of these studies revealed that longer oligopeptide side chains (hexapeptides) terminated with a derivative of 5-fluorouracil could be cleaved by the enzymes whereas the shorter oligopeptide side chains (tetrapeptides) terminated with a derivative of 5-fluorouracil could not. In addition, the compositions of the side chains directly influenced the release of 5-fluorouracil from conjugates. The more hydrophobic the residue next to the 5-fluorouracil derivative the greater the release of the free drug. The second half of the research was designed to evaluate the cell surface biorecognition of polymer glycoconjugates containing different carbohydrate moieties (galactosamine, glucosamine or fucosylamine) and to evaluate the in vitro and in vivo anticancer activity of these glycoconjugates containing 5-fluorouracil toward colon cancer cells. The glycoconjugates bound to and were endocytosed into the cancer cells. The in vitro activity of the glycoconjugates containing 5-fluorouracil was dependent on the carbohydrate moiety (galactosamine>glucosamine>fucosylamine). The in vivo anticancer studies demonstrated that the 5-fluorouracil-containing glycoconjugates indeed had anticancer activity, and the activity depended on the carbohydrate moiety, the route of administration, and the length of treatment.
[Porträt des Ehepaars Emanuel und Mathilde Probst-Schmidt]
Creators: name: Höflinger, Albert
name: Höflinger Photoatelier
Publisher: name: Photo Höflinger
Year: 1920
Subjects: Porträtfotografie
Probst, Emanuel1849-1929

description: [Albert Höflinger]
description: Es handelt sich beim Abzug um eine Reproaufnahme des Fotografen; Datierung gemäss Entwicklung der Reproduktion
description: Namen der abgelichteten Personen gemäss handschriftlicher Notiz auf der Rückseite des Abzugs
Norm-referenced language test selection (Ogiela & Montzka, 2020)
Creators: name: Ogiela, Diane A.
name: Montzka, Jennifer L.
Publisher: name: ASHA journals
Year: 2020
Subjects: Language
Education

description: Purpose: Standardized norm-referenced tests are an important aspect of language assessment for school-age children. This study explored the language test selection practices of school-based speech-language pathologists (SLPs) working with elementary school children suspected of having developmental language disorder. Specifically, we investigated which tests were most commonly selected as clinicians’ first-choice and follow-up tests, which factors impacted their test selection decisions, and what sources of information they used to determine the psychometric quality of tests.Method: School-based SLPs completed a web-based questionnaire regarding their use of norm-referenced language tests. A total of 370 elementary school SLPs completed the questionnaire.Results: The vast majority of participants indicated that omnibus language tests are their first choice of test. For follow-up tests, participants selected semantics tests, especially single-word vocabulary tests, significantly more often than tests of pragmatics, processing skills, and morphology/syntax. Participants identified multiple factors as affecting test selection, including availability, familiarity, psychometric features, and others. Although more SLPs reported using data-based than subjective sources of information to judge the psychometric quality of tests, a substantial proportion reported that they relied on subjective sources.Conclusions: Clinicians have a strong preference for using omnibus language tests. Follow-up test selection does not appear to align with the language difficulties most associated with developmental language disorder. The substantial use of subjective information about psychometric qualities of tests suggests that many SLPs may not attend to the technical meanings of terms such as validity, reliability, and diagnostic accuracy. These results indicate a need for improvement in evidence-based language assessment practices.
Supplemental Material S1. Invitation to participate.
Supplemental Material S2. Questions presented to participants completing the elementary grades portion of the survey.
Ogiela, D. A., & Montzka, J. L. (2020). Norm-referenced language test selection practices for elementary school children with suspected developmental language disorder. Language, Speech, and Hearing Services in Schools. Advance online publication. https://doi.org/10.1044/2020_LSHSS-19-00067
Discrepancies of normal varieties
Creators: name: Urbinati, Stefano
Publisher: name: University of Utah
Year: 2012
Subjects: Algebraic geometry
Canonical
Finite generation
Klt
Non-Q-Gorenstein
Singularities

description: We give an example of a non Q-Gorenstein variety whose canonical divisor has an irrational valuation and an example of a non Q-Gorenstein variety which is canonical but not klt. We also give an example of an irrational jumping number and we prove that there are no accumulation points for the jumping numbers of normal non-Q-Gorenstein varieties with isolated singularities. We prove that the canonical ring of a canonical variety in the sense of [dFH09] is finitely generated. We prove that canonical varieties are klt if and only if R(−KX) is finitely gener-ated. We introduce a notion of nefness for non-Q-Gorenstein varieties and study some of its properties. We then focus on the properties of non-Q-Gorenstein toric varieties, with particular attention to minimal log discrepancies.
[Porträt des Ehepaars Markus und Emilia Lina Guggenheim
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968
Subjects: Porträtfotografie
Guggenheim, Markus1885-1970

description: Unbekannte/r Fotograf/in
description: Name der abgelichteten Personen sowie Datiernug gemäss handschriftlicher Notiz auf der Rückseite des Abzugs
Development of 3-methyl/3-(morpholinomethyl)benzofuran derivatives as novel antitumor agents towards non-small cell lung cancer cells
Creators: name: Al-Sanea, Mohammad M.
name: Al-Ansary, Ghada H.
name: Elsayed, Zainab M.
name: Maklad, Raed M.
name: Elkaeed, Eslam B.
name: Abdelgawad, Mohamed A.
name: Bukhari, Syed Nasir Abbas
name: Abdel-Aziz, Marwa M.
name: Suliman, Howayda
name: Eldehna, Wagdy M.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: As one of the most lethal malignancies, lung cancer is considered to account for approximately one-fifth of all malignant tumours-related deaths worldwide. This study reports the synthesis and in vitro biological assessment of two sets of 3-methylbenzofurans (4a–d, 6a–c, 8a–c and 11) and 3-(morpholinomethyl)benzofurans (15a–c, 16a–b, 17a–b and 18) as potential anticancer agents towards non-small cell lung carcinoma A549 and NCI-H23 cell lines, with VEGFR-2 inhibitory activity. The target benzofuran-based derivatives efficiently inhibited the growth of both A549 and NCI-H23 cell lines with IC50 spanning in ranges 1.48–47.02 and 0.49–68.9 µM, respectively. The three most active benzofurans (4b, 15a and 16a) were further investigated for their effects on the cell cycle progression and apoptosis in A549 (for 4b) and NCI-H23 (for 15a and 16a) cell lines. Furthermore, benzofurans 4b, 15a and 16a displayed good VEGFR-2 inhibitory activity with IC50 equal 77.97, 132.5 and 45.4 nM, respectively.
Nonlinear optical study of metallic subwavelength hole arrays
Creators: name: Xu, Tingjun
Publisher: name: University of Utah
Year: 2012
Subjects: Electron beam lithography
Metallic hole arrays
Nanofabrication
Nonlinear optics
Second harmonic generation
Third harmonic generation

description: Light transmission through small apertures has attracted a lot of attention. Only with the advance of nanofabrication techniques does the study of light transmission through subwavelength apertures and hole arrays in the visible region becomes possible. Although there are numerous studies on the extraordinary optical transmission through hole arrays and potential applications, not much work had been done for the study of the nonlinear phenomena generated from these subwavelength hole arrays. In this thesis, advanced nanofabrication techniques, such as electron beam lithography, have been utilized to fabricate nanometer scaled hole arrays on very thin metal films. Hole arrays with different lattice arrangements, lattice constants and shapes have been fabricated for measurement. Ultrafast laser pulses generated from a Ti:Sapphire oscillator and a regenerative amplifier, which is capable of generating extremely high power laser pulses, are used as the light source for the nonlinear optical study. Nonlinear measurements, including second harmonic generation and third harmonic generation from the fabricated hole arrays, have been performed. Second harmonic generation studies had been focused on how symmetry plays a role in the process of generating second harmonic signal. Results show that upon breaking symmetry by either the illumination or detection angle, or the symmetry of the aperture itself, very strong nonlinear signals from the nanohole arrays can be generated. For third harmonic generation, the symmetry requirement is less restrictive, but follows the same principle: the highest harmonic signals are produced upon the extraordinary transmission of the fundamental light. The effects of the adhesion layer, the lattice arrangements, lattice constant, aperture shape and nonlinear filling material inside the apertures have been studied for both second harmonic generation and third harmonic generation. As preliminary efforts towards generating supercontinuum from these hole arrays, luminescence from Au has been studied.
Profile of the competency requirements for effective job performance in the head nurse role
Creators: name: Russon, Alene M.
Publisher: name: University of Utah
Year: 2012
Subjects: Performance Characteristics Inventory
Job Perceptions

description: The purpose of this research was to produce a profile of the competencies which are most important to effective performance in the head nurse role.  The population included 61 head nurses in Salt Lake City, Utah who have been in that position for at least 6 months, and who work in major acute care hospitals in the area.  The research design employed was a survey and data were obtained by use of the Performance Characteristics Inventory (PCI) designed by McBer and Company, Boston, Massachusetts.  The results of this research raise questions for both nursing educators and administrators:  a) Do educational programs appropriately prepare nurses to be managers?  b) Do head nurses and their supervisors have the same perceptions of the job and job expectations? c) Do hospital and nursing systems, policies and procedures allow head nurses to manage" in an effective manner?
Cyclocephala meinanderi Endrodi 1964
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala meinanderi

description: Cyclocephala meinanderi Endrödi, 1964
Cyclocephala meinanderi Endrödi 1964: 457 (Mexico)
Distribution. French Guiana: Dechambre 1979c: 164; Duranton 2011: 13; Ponchel 2011: 60; Dupuis 2016b: 109. Brazil: Endrödi 1964: 457, 1966a: 254; Dechambre 1979c: 164. Other: Endrödi 1964: 457 (Mexico), 1966a: 254 (Bolivia, Mexico, Paraguay), 1985a: 88 (treated as an aberration of C. gravis); Dechambre 1979c: 164 (Bolivia, Mexico, Paraguay).
Note 1. Endrödi (1964: 457) describes Cyclocephala meinanderi. The species is reduced to an aberration of C. gravis in Endrödi (1967b: 90), and this is upheld in Endrödi (1985a: 88). Dechambre (1979c: 164) reinstates it as a valid species and explains this decision. Ratcliffe (B. Ratcliffe, pers. comm. 2014) and Moore et al. (2018b: 181) still consider it a form of C. gravis.
Note 2. Despite the fact that the, possibly incorrect, type locality of Cyclocephala meinanderi is Mexico, this species is not mentioned in the treatment of the Dynastinae of Mexico, Guatemala and Belize by Ratcliffe et al. (2013).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 174, DOI: 10.5281/zenodo.3678492
Phenyl-substituted aminomethylene-bisphosphonates inhibit human P5C reductase and show antiproliferative activity against proline-hyperproducing tumour cells
Creators: name: Forlani, Giuseppe
name: Sabbioni, Giuseppe
name: Ragno, Daniele
name: Petrollino, Davide
name: Borgatti, Monica
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: In certain cancers, such as breast, prostate and some lung and skin cancers, the gene for the enzyme catalysing the second and last step in proline synthesis, δ1-pyrroline-5-carboxylate (P5C) reductase, has been found upregulated. This leads to a higher proline content that exacerbates the effects of the so-called proline-P5C cycle, with tumour cells effectively using this method to increase cell survival. If a method of reducing or inhibiting P5C reductase could be discovered, it would provide new means of treating cancer. To address this point, the effect of some phenyl-substituted derivatives of aminomethylene-bisphosphonic acid, previously found to interfere with the catalytic activity of plant and bacterial P5C reductases, was evaluated in vitro on the human isoform 1 (PYCR1), expressed in E. coli and affinity purified. The 3.5-dibromophenyl- and 3.5-dichlorophenyl-derivatives showed a remarkable effectiveness, with IC50 values lower than 1 µM and a mechanism of competitive type against both P5C and NADPH. The actual occurrence in vivo of enzyme inhibition was assessed on myelogenous erythroleukemic K562 and epithelial breast cancer MDA-MB-231 cell lines, whose growth was progressively impaired by concentrations of the dibromo derivative ranging from 10−6 to 10−4 M. Interestingly, growth inhibition was not relieved by the exogenous supply of proline, suggesting that the effect relies on the interference with the proline-P5C cycle, and not on proline starvation.
[Zug einer Basler Kompagnie]
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1865
Subjects: Porträtfotografie
Zug

description: Zug einer Basler Militärkompagnie mit Fritz Preiswerk in der hinteren Reihe, dritter von rechts
description: J. Jungmann Fotografie
description: Name des Fotografen gemäss Prägedruck am unteren Rand des Passepartouts
description: Abzug inPassepartout
Uhrumstellung in Basel 1779
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1779
Subjects: Druckgrafik
Bernoulli, Daniel1700-1782

description: Karikatur des Daniel Bernoulli, der die Uhr eine Stunde angehalten hatte und vom Schneider Rudolf Langmesser übergangen wird und die Uhr wiederum einen Stunde vorstellt
description: D. de Rutte fec.
description: Datierung sowie Titel gemäss handschriftlicher Notiz auf der Rückseite der Druckgrafik
Middle-aged caregivers: an exploratory study of three cohorts
Creators: name: Sobczak, Margaret
Publisher: name: University of Utah
Year: 2012
Subjects: Middle Age

description: A large, cross-sectional survey of caregivers to dementia patients provided the data base to study the effects of caregivers' age on the dependent variables of caregiver income, marital and employment statuses, their depression level, perceptions of burden, life satisfaction, number of persons in the support system, and the functional level of the dementia patient. The sample consisted of 180 female caregivers between 35 and 64 years of age who were identified from support groups located in the Western half of the United States. Using the Pearson r correlation coefficient as a statistical measure of the variables under study, an inverse relationship was demonstrated between caregiver age, income, and employment. No significant correlations existed between caregiver age and the other variables under study. After dividing the sample into their age cohorts (35-44, 45-54, and 55-64 years of age), further data analyses using ANOVA failed to reveal significant age-related group differences based on the major dependent variables under study. With the small number of dependent variables used to study age, the results of this study are inconclusive.
[Porträt der Anna Riggenbach-Oser mit Ihrer Tochter Marianne]
Creators: name: Kling-Jenny, Carl
Publisher: name: [s.n.]
Year: 1901
Subjects: Porträtfotografie
Riggenbach-Oser, Anna1852-1933
Riggenbach, Marianne1894-1971

description: C. Kling-Jenny
description: Abzug auf eine Kabinettkarte montiert
description: Namen der abgelichteten Personen gemäss handschriftlicher Notiz auf der Rückseite der Kabinettkarte
description: Datierung gemäss Prägestempel an der unteren rechten Ecke des Abzugs
[Porträt des Traugott und der Marianne Riggenbach]
Creators: name: Höflinger, Jakob
name: Höflinger Photoatelier
Publisher: name: J. Höflinger und Sohn
Year: 1896
Subjects: Porträtfotografie

description: [Höflinger, Jakob]
description: Abzug auf eine Kabinettkarte montiert
description: Namen der abgelichteten Personen gemäss handschriftlicher Notiz auf der Rückseite der Kabinettkarte
Dimension results for two random fractals
Creators: name: Zhang, Liang
Publisher: name: University of Utah
Year: 2012
Subjects: Additive Levy processes
Fractal percolation
Hausdorff dimension
Limsup random fractals
Packing dimension

description: Random fractals are sets generated by random processes that exhibit fractal properties. These properties can be described by proper fractal dimensions. Hausdor dimension and packing dimension are two fractal dimensions that are of most interest. In this thesis two different random fractals are investigated and their fractal dimensions are computed. The first random fractal studied is the image of an additive Levy process. Let X = {X (t) : t ϵ RN +} denote an additive Levy process and F Ϲ RN + a Borel set. We define a new packing dimension profile Dim and show that the packing dimension of the image set X (F) is equal to Dim (F) almost surely. Moreover we show that our packing dimension profile gives probabilistic interpretations to the packing dimension profiles defined by Falconer and Howroyd in their study of orthogonal projection. The second random fractal studied is the limsup random fractal. A limsup random fractal is generated by limsup operations and is a model for many other random sets including fast points and thick points of a Brownian motion. We study limsup random fractals defined on the boundary of a spherically symmetric tree and estimate the probability that a limsup random fractal hits an independent fractal percolation set. By a codimension argument, we compute the Hausdor dimension of limsup random fractals and packing dimension of fractal percolation sets. This solves in part a problem introduced by Khoshnevisan, Peres, and Xiao.
Different roles for the acyl chain and the amine leaving group in the substrate selectivity of N-Acylethanolamine acid amidase
Creators: name: Ghidini, Andrea
name: Scalvini, Laura
name: Palese, Francesca
name: Lodola, Alessio
name: Mor, Marco
name: Piomelli, Daniele
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: N-acylethanolamine acid amidase (NAAA) is an N-terminal nucleophile (Ntn) hydrolase that catalyses the intracellular deactivation of the endogenous analgesic and anti-inflammatory agent palmitoylethanolamide (PEA). NAAA inhibitors counteract this process and exert marked therapeutic effects in animal models of pain, inflammation and neurodegeneration. While it is known that NAAA preferentially hydrolyses saturated fatty acid ethanolamides (FAEs), a detailed profile of the relationship between catalytic efficiency and fatty acid-chain length is still lacking. In this report, we combined enzymatic and molecular modelling approaches to determine the effects of acyl chain and polar head modifications on substrate recognition and hydrolysis by NAAA. The results show that, in both saturated and monounsaturated FAEs, the catalytic efficiency is strictly dependent upon fatty acyl chain length, whereas there is a wider tolerance for modifications of the polar heads. This relationship reflects the relative stability of enzyme-substrate complexes in molecular dynamics simulations.
title: Memoria 2013
Creators: name: Universidad Especializada de las Américas, UDELAS
Publisher: name: Universidad Especializadas de las Américas
Year: 2019
Subjects: subject: FOS: Educational sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: El documento hace mención de la labor efectuada por la Universidad Especializada de las Américas durante el año 2013, con pasos firmes hacia la excelencia académica.
Brief an [Johann Bernoulli]
Creators: name: Lengnich, Karl Benjamin
Publisher: name: [s.n.]
Year: 1785

description: von [Carl Benjamin] Lengnich
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
description: Bl. 233: Notiz
description: Basel UB, L Ia 728:Bl.198-201
Cyclocephala melanocephala
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala melanocephala

description: Cyclocephala melanocephala (Fabricius, 1775)
Melolontha melanocephala Fabricius 1775: 36 (Brazil)
= Cyclocephala dimidiata Burmeister 1847: 57 (Mexico)
= Cyclocephala rubiginosa Burmeister 1847: 59 (Martinique) - Ratcliffe and Cave 2015: 99 (syn. nov.)
Distribution. Guyana: Bodkin 1919: 215 (as C. dimidiata); Endrödi 1966a: 256; Moore et al. 2018b: 211. Suriname: Endrödi 1966a: 256; Moore et al. 2018b: 211; MHCN, NZCS. French Guiana: Duranton 2011: 13; Dupuis 2016b: 109; Moore et al. 2018b: 211. Brazil (NA): Fabricius 1775: 36 (as Melolontha melanocephala); Burmeister 1847: 56; Arrow 1937b: 13; Blackwelder 1944: 252; Endrödi 1966a: 256; Moore et al. 2018b: 211 (NA). Venezuela (EO): Endrödi 1966a: 256 (EO); Moore et al. 2018b: 211 (EO). Other: Burmeister 1847: 57, 59 (Mexico - as C. dimidiata; Martinique - as C. rubiginosa); Arrow 1937b: 10, 15 (Mexico, U.S.A. - as C. dimidiata; Martinique - as C. rubiginosa); Blackwelder 1944: 251, 252 (Costa Rica, Grenada, Guatemala, Mexico, Nicaragua, Panama, U.S.A. - as C. dimidiata; Argentina - as C. melanocephala; Martinique - as C. rubiginosa); Endrödi 1966a: 256, 297 (Argentina, Bolivia, Colombia, Costa Rica, Ecuador, Guatemala, Honduras, Nicaragua, Mexico, Panama, Paraguay, Peru, Trinidad and Tobago, U.S.A., West Indies - as C. melanocephala; Martinique - as C. rubiginosa), 1985a: 103, 141 (Argentina–U.S.A. - as C. melanocephala melanocephala; Guadeloupe - as C. melanocephala rubiginosa); Lachaume 1992: 15 (Argentina–U.S.A.); Ratcliffe 2003: 162 (Argentina/Paraguay–U.S.A.); Ponchel 2011 (not mentioned); Ratcliffe and Cave 2015: 99 (Argentina–U.S.A., Lesser Antilles); Moore et al. 2018b: 211 (Argentina, Belize, Bolivia, Colombia, Costa Rica, Ecuador, El Salvador, Guatemala, Honduras, Mexico, Nicaragua, Panama, Paraguay, Peru, Trinidad and Tobago, U.S.A., West Indies).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 174, DOI: 10.5281/zenodo.3678492
Transferability of medical knowledge-base: a case study between INTERNIST-1 and HELP
Creators: name: Nguyen, Long Thanh
Publisher: name: University of Utah
Year: 2012

description: Transfer of a knowledge-base between systems is necessitated by the great difficulties encountered in acquiring human expert knowledge for computer expert system utilization. Moreover, testing the robustness of the original knowledge-base in a new environment and expanding the domain of the receiving systems are also additional Incentives for performing a knowledge transfer. This project investigated the transfer of the medical knowledge-base embedded in the INTERNIST-1, a medical diagnostic expert system, onto the HELP, a total hospital information system. Analyses of the structures as well as the algorithms used in both systems were used as the basis for finding a suitable transferring scheme. In the empirical transfer of diseases that involve the gastrointestinal tract, the main behavioral features of the INTERNIST-1 as well as the modularity inherent In the HELP system are preserved. An attempt to reduce the information used In making the diagnosis was carried out by assuming that some information is in the noise level and, therefore, expendable. A different, but equivalent, disease scoring algorithm prompted a new look Into the role of the IMPORTANCE concept as it plays in the scoring process of the INTERNIST-1. A more comprehensive index was developed to control the ASKING process. The success of the transfer was measured by the ease of the transfer and by comparing the performance of the hybrid prototype, i.e., the HELP version of the INTERNIST-1, to that of the INTERNIST-1 itself.
ICHKI TURIZMNI RIVOJLANTIRISH UCHUN FOYDALANILAYOTGAN MAHALLIY ILOVALAR VA ULARNI YARATISH TEXNOLOGIYALARI
Creators: name: Musirmanov, Shohboz
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqola ichki turizmni rivojlantirish uchun mahalliy ilovalardan foydalanish va ularni yaratishda ishtirok etadigan texnologiyalarni o'rganadi. Unda mahalliy turizmni rivojlantirish, tashrif buyuruvchilar tajribasini oshirish va barqaror turizm amaliyotlarini qo‘llab-quvvatlash uchun bunday ilovalardan foydalanishning afzalliklari muhokama qilinadi. Maqolada, shuningdek, ichki turizm uchun mahalliy ilovalarni ishlab chiqish va amalga oshirishdagi asosiy texnologiyalar, muammolar va imkoniyatlar yoritilgan.
Brief an Johann Bernoulli
Creators: name: Lengnich, Karl Benjamin
Publisher: name: [s.n.]
Year: 1785

description: von [Carl Benjamin] Lengnich
description: Mit Oblate
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Relationship between selected personality variables measured by the patterns of social adaptation scale and the sixteen personality factor questionnaire
Creators: name: Christensen, Joyce Clara
Publisher: name: University of Utah
Year: 2012
Subjects: Nusring Students
Traits

description: The problem of this investigation was to examine the validity of the Patterns of Social Adaptation (PSA) Assertion Scale.  The instrument was administered concurrently with the Sixteen Personality Factor Questionnaire (16PF), to 10 8 undergraduate nursing students.  All of the subjects were women; the mean age was 23.6.  Significant correlations were found between the PSA self-report measure of assertiveness and four source traits of the 16PF: outgoing, assertive, venturesome and self assured.  A multiple regression analysis suggested that self-report of assertiveness may be partially explained by these four 2 16PF source traits (R =.252).  The results are consistent with a general hypothesis that the PSA has some validity as a measure of assertion.  The nature of the relationships between the PSA Assertive Scale and the 16PF source traits also correspond with prior descriptive and empirical discussions of assertiveness.
Plasminogen activator from cultured baby hamster kidney cells
Creators: name: Snyder, Robert Wickert
Publisher: name: University of Utah
Year: 2012
Subjects: Biochemistry
Proteases

description: A large number of cell clones were isolated which produced different amount of extracellular plasminogen activator.  These clones were identified and selected by use of an overlay medium containing casein and plasminogen.  All cells obtained by this method arose from a high passage cell line (BHK-21/N) which had been originally cloned from BKH-21/C13 cells.  These cloned isolated from BHK-21/N were characterized with respect to their growth rates and efficiencies of plating in soft agar and on plastic surfaces.  No correlations were found between any of these growth properties and the amounts of extracellular plasminogen activator as detected in serum-free cell culture media.  A plasminogen activator which was produced by a high passage hamster kidney cell (Hpa-6) was characterized biochemically.  The enzyme was found to be inhibited by diisopropylfluorophosphate and therefore was considered serine protease.  Hpa-6 antivator was also found to react with plasminogen in a manner which was indistinguishable from the action of urokinase on the proenzyme.  Evidence was obtained which suggests that the activator can hydrolyze either of the two molecular forms of plasminogen, i.e., plasminogen with glutamic acid amino terminus or plasminogen with lysine amino terminus at a single position to yield active plasmin.  The cellular localization of the Hpa-6 cell plasminogen activator was examined and the results obtained indicate that this activity was largely associated with the plasma membrane.
Brief an Joh[ann] Bernoulli
Creators: name: Lengnich, Karl Benjamin
Publisher: name: [s.n.]
Year: 1785

description: von [Carl Benjamin] Lengnich
description: Mit Oblate
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Why arts and humanities publications get retracted: a topic modeling analysis of the retraction notices
Creators: name: Heibi, Ivan
name: Peroni, Silvio
Publisher: name: Zenodo
Year: 2022
Subjects: topic modeling
humanities
retraction

description: The slides used in the presentation held by Ivan Heibi in the context of the Digital Humanities 2022 (DH2022) Conference. Abstract Considering the less attention that has been given to the study of the retraction phenomenon and, to the reasons for retraction in the arts and humanities domain, the aim of this work is to investigate the reasons for retraction in the arts and humanities through automatic textual analysis of the retraction notices and a comparison of these results with the data provided by other services which have worked on labeling such reasons such as Retraction Watch.
New azolyl-derivatives as multitargeting agents against breast cancer and fungal infections: synthesis, biological evaluation and docking study
Creators: name: Maccallini, Cristina
name: Gallorini, Marialucia
name: Sisto, Francesca
name: Akdemir, Atilla
name: Ammazzalorso, Alessandra
name: De Filippis, Barbara
name: Fantacuzzi, Marialuigia
name: Giampietro, Letizia
name: Carradori, Simone
name: Cataldi, Amelia
name: Amoroso, Rosa
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Nonsteroidal aromatase inhibitors (NSAIs) are well-established drugs for the therapy of breast cancer. However, they display some serious side effects, and their efficacy can be compromised by the development of chemoresistance. Previously, we have reported different indazole-based carbamates and piperidine-sulphonamides as potent aromatase inhibitors. Starting from the most promising compounds, here we have synthesised new indazole and triazole derivatives and evaluated their biological activity as potential dual agents, targeting both the aromatase and the inducible nitric oxide synthase, being this last dysregulated in breast cancer. Furthermore, selected compounds were evaluated as antiproliferative and cytotoxic agents in the MCF-7 cell line. Moreover, considering the therapeutic diversity of azole-based compounds, all the synthesized compounds were also evaluated as antifungals on different Candida strains. A docking study, as well as molecular dynamics simulation, were carried out to shed light on the binding mode of the most interesting compound into the different target enzymes catalytic sites.
Brief an [Johann] Bernoulli
Creators: name: Lengnich, Karl Benjamin
Publisher: name: [s.n.]
Year: 1785

description: von [Carl Benjamin] Lengnich
description: Mit Oblate
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Cyclocephala minuta Burmeister 1847
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala minuta

description: Cyclocephala minuta Burmeister, 1847
Cyclocephala minuta Burmeister 1847: 59 (French Guiana - LECTOTYPE)
Distribution. Guyana: Endrödi 1966a: 259, 1985a: 102, 146; Lachaume 1992: 15; Moore et al. 2018b: 215. Suriname: Endrödi 1966a: 259, 1985a: 102, 146; Lachaume 1992: 15; Moore et al. 2018b: 215; MHCN; NZCS. French Guiana: Burmeister 1847: 59; Arrow 1937b: 13; Blackwelder 1944: 252; Endrödi 1966a: 259 (designation LECTOTYPE Cyclocephala minuta), 1985a: 102, 146; Lachaume 1992: 15; Duranton 2011: 14; Ponchel 2011: 60; Dupuis 2016b: 109; Moore et al. 2018b: 215. Venezuela (EO): Endrödi 1966a: 259, 1985a: 102, 146; Lachaume 1992: 15; Moore et al. 2018b: 215; Kirmse and Ratcliffe 2019: 153 (EO). Other: Endrödi 1966a: 259 (Paraguay); Moore et al. 2018b: 215 (Paraguay).
Note. Endrödi (1966a: 259) records Cyclocephala minuta for Paraguay, and this record is repeated in Moore et al. (2018b: 215), although the district name Sapucay is here exchanged for the departmental name Paraguarí. Given the distance of over 3,000 km between the location in Paraguay and the rest of the distributional area, and because the species has never again been reported for Paraguay, we believe this record is based on a mislabeled or misidentified specimen.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 175, DOI: 10.5281/zenodo.3678492
Role for RNA association in the function of the nuclear pore protein Nup153
Creators: name: Dimaano, Christian
Publisher: name: University of Utah
Year: 2012
Subjects: Nucleoporin
RNA Binding

description: Communication between the nucleus and the cytoplasm is dependent upon transport across the double membrane of the nuclear envelope. All traffic between the nucleus and cytoplasm occurs at large proteinacious structures embedded within the nuclear envelope called nuclear pore complexes (NPCs). Trafficking of a wide array of cargo necessitates that individual pore proteins coordinately function with localization signals, receptors, and accessory factors to mediate propel-transport events. Although much is known about the soluble machinery that is required for nucleocytoplasmic transport, little is known about how individual nucleoporins contribute to this process. One nucleoporin, Nup153, is a central regulator of transport. Overexpression of a C-terminal fragment of Nup153 in cultured cells causes the accumulation of poly(A)+ RNA in the nucleus, suggesting a role for Nup153 in mRNA export. Moreover, specific perturbation of Nup153 in vivo results in the prevention of several classes of RNA, including mRNA, from being exported. The goal of this dissertation is to define how the property of RNA association contributes to the function of this pore protein. I have examined the interaction of Nup153 with RNA and identified a novel RNA binding domain within this pore protein that is sufficient to mediate this property. My studies indicate an important functional attribute of RNA association, as this domain is functionally conserved through evolution. I have also assisted in further characterizing Nup153's RNA binding properties and we have found that Nup153 shows a preference for single-stranded RNAs that lack structure. Unstructured stretches of single-stranded RNA are defined to be mRNA identity elements and raise the possibility that the RNA binding domain of Nup153 acts as an interface with mRNA. To better define the RNA determinants that mediate Nup153 recognition, we have established minimal length and base composition requirements. Our findings show for the first time that binding of RNA substrates by a nucleoporin can be correlated with nuclear export. In addition, I contributed to a project focused on Nup153 nuclear mobility and we found that dynamics of this pore protein in the nucleus is dependent upon on-going transcription, supporting a connection between Nup153 function and mRNA production.
Tuning the activity of iminosugars: novel N-alkylated deoxynojirimycin derivatives as strong BuChE inhibitors
Creators: name: Ahuja-Casarín, Ana I.
name: Merino-Montiel, Penélope
name: Vega-Baez, José Luis
name: Montiel-Smith, Sara
name: Fernandes, Miguel X.
name: Lagunes, Irene
name: Maya, Inés
name: Padrón, José M.
name: López, Óscar
name: Fernández-Bolaños, José G.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Neuroscience
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: We have designed unprecedented cholinesterase inhibitors based on 1-deoxynojirimycin as potential anti-Alzheimer’s agents. Compounds are comprised of three key structural motifs: the iminosugar, for interaction with cholinesterase catalytic anionic site (CAS); a hydrocarbon tether with variable lengths, and a fragment derived from 2-phenylethanol for promoting interactions with peripheral anionic site (PAS). Title compounds exhibited good selectivity towards BuChE, strongly depending on the substitution pattern and the length of the tether. The lead compounds were found to be strong mixed inhibitors of BuChE (IC50 = 1.8 and 1.9 µM). The presumptive binding mode of the lead compound was analysed using molecular docking simulations, revealing H-bond interactions with the catalytic subsite (His438) and CAS (Trp82 and Glu197) and van der Waals interactions with PAS (Thr284, Pro285, Asn289). They also lacked significant antiproliferative activity against tumour and non-tumour cells at 100 µM, making them promising new agents for tackling Alzheimer’s disease through the cholinergic approach.
Case study approach to health science: design and implementation of an online course
Creators: name: Newton, Kathryn Turner
Publisher: name: University of Utah
Year: 2012
Subjects: Online Courses
Implementation
Technology

description: Distance education has evolved from traditional correspondence courses by mail to courses utilizing the latest developments in technology. With the advent of the Internet, distance education has grown exponentially.  Internet-based courses add to the traditional advantages of distance education of eliminating barriers of time and space. They allow for enhanced communication, collaboration, and community.  The design and implementation of an Internet-based course, A Case Study Approach to Health Science,"" forms the basis of this thesis. This course was developed through Weber State University (WSU), by Roger C. Nichols, Professor of Clinical Laboratory Science and Assistant Dean of the Allied College of Health Sciences, and Kathryn T. Newton, adjunct professor of Clinical Laboratory Science, and author of this thesis. The course was designed for concurrent enrollment students, secondary students participating in college courses offered at their respective high schools. This is the first attempt through WSU to introduce an Internet-based course to concurrent students. The course was also developed to generate exposure and recruit students to various health professions.  This thesis will discuss the background of distance education, effective design strategies of an online course, and the design of the ""Case Study"" course. It will conclude with a discussion of beta and pilot testing in select secondary schools.""
Brief an [Johann Bernoulli]
Creators: name: Lengnich, Karl Benjamin
Publisher: name: [s.n.]
Year: 1785

description: von [Carl Benjamin] Lengnich
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
REHABILITATION AND RETURN TO PLAY AFTER SINGLE-STAGE BILATERAL ACL RECONSTRUCTION: A REVIEW & CASE SERIES
Creators: name: Sambhav Sharma
name: Sai Aditya Raman
name: Dr. Suresh Perumal
name: Parthiban VJ
name: Arumugam S
Publisher: name: Zenodo
Year: 2024
Subjects: Bilateral ACL tear, Bilateral ACL reconstruction, Return to sport, Rehabilitation.

description: Abstract

Background & Aim: Anterior cruciate ligament (ACL) injuries are common among athletes and require surgical intervention to restore knee stability and function. Successful rehabilitation is crucial in facilitating safe and efficient return to sport. Bilateral ACL injuries, though rare, can result in significant career time loss in professional athletes. Single-stage bilateral ACL reconstruction (SBACLR) could be an efficient approach in such cases but poses unique challenges for rehabilitation. Outcomes of SBACLR and rehabilitation factors to be considered in the preoperative & postoperative phases have been inadequately researched and is the focus of the present study. Methods: Ten athletes with bilateral ACL injuries underwent SBACLR using hamstring (STG) or bone-patellar tendon-bone (BTB) autografts, depending on individual factors. A criteria-based postoperative rehabilitation protocol emphasising early mobilisation, progressive weight-bearing, muscle strengthening and proprioceptive exercises was administered under supervision until 18 months post-surgery. Results: At 18 months post-surgery, improvement in knee stability, range of motion and self-reported functional outcomes were observed in all athletes. The rehabilitation protocol facilitated gradual return to sport in less than 15 months in all athletes. Conclusions: SBACLR coupled with a rehabilitation protocol emphasising early mobilisation and criteria-based progression is a successful treatment option for athletes ensuring safe and efficient return to sport, with optimal outcomes in knee function, stability, and athlete satisfaction.
Structural and functional studies of ALIX in retroviral budding
Creators: name: Zhai, Qianting
Publisher: name: University of Utah
Year: 2012
Subjects: ALIX
ESCRT machinery
retroviral budding
SAXS
Tetherin/BST2/CD317
X-ray crystallography

description: The cellular protein ALIX and other ESCRT proteins facilitate topologically equivalent membrane abscission events, including viral envelope separation from host membranes, biogenesis of multi-vesicular bodies, and midbody scission at the late stage of cytokinesis. Late domain motifs displayed by retroviral Gag polyproteins are responsible for recruiting ESCRT proteins. The three best-characterized classes of late domains are:  the "P(S/T)AP" late domains that bind TSG101 of the ESCRT-I complex, the "PPXY" late domains that bind NEDD4 family ubiquitin E3 ligases, and the  "YPXnL" late domains that bind ALIX. ALIX also binds the ESCRT-III protein CHMP4, which recruits other ESCRT-III subunits and VPS4 complexes to carry out membrane fission.  My work in this dissertation is centered on how ALIX is recruited by various retroviruses and how ALIX function is regulated in viral budding. We first determined crystal structures of ALIXBro1, ALIXV and ALIXBro1-V. Second,  in order to understand how the viral Gag proteins hijack ALIX, we determined the structure of ALIXBro1-V in complex with HIV and EIAV YPXnL late motifs. Third, we used surface plasmon resonance (SPR) to map a new  type of ALIX-binding elements from certain SIV strains, which do not contain the canonical YPXnL late domains and still package ALIX in the virions.  Furthermore, the new ALIX-binding motifs were crystallized with ALIXBro1-V. All these late-domain ligands adopt different conformations of backbones to  interact with the equivalent interface on the ALIX V domain. Based on sequence analysis, nearly every known primate lentiviruses contains an ALIX-binding site, suggesting that the ability to recruit ALIX provide a  strong selective advantage for viruses. Fourth, we discovered that the fulllength ALIX is autoinhibited by its C-terminal proline-rich region (PRR), which blocks the interaction of viral late domains based on the results of  isothermal titration calorimetry (ITC), SPR and small-angle X-ray scattering (SAXS). The mutation that opens the closed conformation of the V domain  partitioned ALIX into membrane-containing fractions and enhanced virus budding. These observations suggest that the function of ALIX is highly regulated, and ALIX activation requires dissociation of the autoinhibitory  PRR, opening of the V domain, and probably protein dimerization.