cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Neoadjuvant Sequential Docetaxel Followed by High-Dose Epirubicin in Combination With Cyclophosphamide Administered Concurrently With Trastuzumab. The DECT Trial
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2016
Subjects: Adult
Aged
Antineoplastic Combined Chemotherapy Protocols
Body Mass Index
Breast Neoplasms
Cyclophosphamide
Docetaxel
Dose-Response Relationship, Drug
Epirubicin
Female
Humans
Middle Aged
Neoadjuvant Therapy
Neoplasm Staging
Taxoids
Trastuzumab

description: © 2016 The Authors. Journal of Cellular Physiology Published by Wiley Periodicals, Inc. To report the results of the DECT trial, a phase II study of locally advanced or operable HER2-positive breast cancer (BC) treated with taxanes and concurrent anthracyclines and trastuzumab. Eligible patients (stage IIA-IIIB HER2-positive BC, 18–75 years, normal organ functions, ECOG ≤1, and left ventricular ejection fraction (LVEF) ≥55%) received four cycles of neoadjuvant docetaxel, 100 mg/m2 intravenously, plus trastuzumab 6 mg/kg (loading dose 8 mg/kg) every 3 weeks, followed by four 3-weekly cycles of epirubicin 120 mg/m2 and cyclophosphamide, 600 mg/m2, plus trastuzumab. Primary objective was pathologic complete response (pCR) rate, defined as ypT0/is ypN0 at definitive surgery. We enrolled 45 consecutive patients. All but six patients (13.3%) completed chemotherapy and all underwent surgery. pCR was observed in 28 patients (62.2%) overall and in 6 (66.7%) from the inflammatory subgroup. The classification and regression tree analysis showed a 100% pCR rate in patients with BMI ≥25 and with hormone negative disease. The median follow up was 46 months (8–78). Four-year recurrence-free survival was 74.7% (95%CI, 58.2–91.2). Seven patients (15.6%) recurred and one died. Treatment was well tolerated, with limiting toxicity being neutropenia. No clinical cardiotoxicity was observed. Six patients (13.4%) showed a transient LVEF decrease (<10%). In one patient we observed a ≥10% asymptomatic LVEF decrease persisting after surgery. Notwithstanding their limited applicability due to the current guidelines, our findings support the efficacy of the regimen of interest in the neoadjuvant setting along with a fairly acceptable toxicity profile, including cardiotoxicity. Results on BMI may invite further assessment in future studies. J. Cell. Physiol. 231: 2541–2547, 2016. © 2016 The Authors. Journal of Cellular Physiology Published by Wiley Periodicals, Inc.
Supplementary document for Tripling the spatial resolution of light field displays without losing angular resolution by computational subpixel realignment - 6725368.pdf
Creators: name: Yang, Wenchao
name: Cheng, Yunfan
name: Zou, Guowei
name: Yang, Bo-Ru
name: Qin, Zong
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: Uncategorized

description: Supplemental document
Understanding help-seeking intentions in male military cadets: An application of perceptual mapping
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2016
Subjects: Perceptual Mapping
Males
Help-seeking
Communication
Perceived Control

description: © 2016 Bass et al. Background: Research suggests that men are less likely to seek help for depression, substance abuse, and stressful life events due to negative perceptions of asking for and receiving help. This may be exacerbated in male military cadets who exhibit higher levels of gender role conflict because of military culture. Methods: This exploratory study examined the perceptions of 78 male military cadets toward help-seeking behaviors. Cadets completed the 31-item Barriers to Help Seeking Scale (BHSS) and a component factor analysis was used to generate five composite variables and compare to validated factors. Perceptual mapping and vector modeling, which produce 3-dimensional models of a group's perceptions, were then used to model how they conceptualize help-seeking. Results: Factor analysis showed slightly different groupings than the BHSS, perhaps attributed to different characteristics of respondents, who are situated in a military school compared to general university males. Perceptual maps show that cadets perceive trust of doctors closest to them and help-seeking farthest, supporting the concept that these males have rigid beliefs about having control and its relationship to health seeking. Differences were seen when comparing maps of White and non-White cadets. White cadets positioned themselves far away from all variables, while non-White cadets were closest to "emotional control". Conclusion: To move these cadets toward help-seeking, vector modeling suggests that interventions should focus on their general trust of doctors, accepting lack of control, and decreasing feelings of weakness when asking for help. For non-White cadets a focus on self-reliance may also need to be emphasized. Use of these unique methods resulted in articulation of specific barriers that if addressed early, may have lasting effects on help-seeking behavior as these young men become adults. Future studies are needed to develop and test specific interventions to promote help-seeking among military cadets.
Blurred maximal cyclically monotone sets and bipotentials
Creators: name: Buliga, Marius
name: de Saxce, Gery
name: Vallee, Claude
Publisher: name: arXiv
Year: 2009
Subjects: subject: Functional Analysis (math.FA)
subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 49J53, 49J52, 26B25

description: Let X be a reflexive Banach space and Y its dual. In this paper we find necessary and sufficient conditions for the existence of a bipotential for a blurred maximal cyclically monotone graph. Equivalently, we find a necessary and sufficient condition on $ϕ\in Γ_{0}(X)$ for that the differential inclusion $y \in \bar{B}(ε) + \partial ϕ(x)$ can be put in the form $y \in \partial b(\cdot, y)(x)$, with $b$ a bipotential.
description: Revised version, corrections in theorem 6.2
Probing the primordial power spectra with inflationary priors
Creators: name: Kawasaki, Masahiro
name: Sekiguchi, Toyokazu
Publisher: name: arXiv
Year: 2009
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We investigate constraints on power spectra of the primordial curvature and tensor perturbations with priors based on single-field slow-roll inflation models. We stochastically draw the Hubble slow-roll parameters and generate the primordial power spectra using the inflationary flow equations. Using data from recent observations of CMB and several measurements of geometrical distances in the late Universe, Bayesian parameter estimation and model selection are performed for models that have separate priors on the slow-roll parameters. The same analysis is also performed adopting the standard parameterization of the primordial power spectra. We confirmed that the scale-invariant Harrison-Zel'dovich spectrum is disfavored with increased significance from previous studies. While current observations appear to be optimally modeled with some simple models of single-field slow-roll inflation, data is not enough constraining to distinguish these models.
description: 23 pages, 3 figures, 7 tables, accepted for publication in JCAP
Muscle moment arms and sensitivity analysis of a mouse hindlimb musculoskeletal model
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2016
Subjects: biomechanics
muscle architecture
muscle force
musculoskeletal anatomy
rodent

description: © 2016 The Authors. Journal of Anatomy published by John Wiley & Sons Ltd on behalf of Anatomical Society. Musculoskeletal modelling has become a valuable tool with which to understand how neural, muscular, skeletal and other tissues are integrated to produce movement. Most musculoskeletal modelling work has to date focused on humans or their close relatives, with few examples of quadrupedal animal limb models. A musculoskeletal model of the mouse hindlimb could have broad utility for questions in medicine, genetics, locomotion and neuroscience. This is due to this species’ position as a premier model of human disease, having an array of genetic tools for manipulation of the animal in vivo, and being a small quadruped, a category for which few models exist. Here, the methods used to develop the first three-dimensional (3D) model of a mouse hindlimb and pelvis are described. The model, which represents bones, joints and 39 musculotendon units, was created through a combination of previously gathered muscle architecture data from microdissections, contrast-enhanced micro-computed tomography (CT) scanning and digital segmentation. The model allowed muscle moment arms as well as muscle forces to be estimated for each musculotendon unit throughout a range of joint rotations. Moment arm analysis supported the reliability of musculotendon unit placement within the model, and comparison to a previously published rat hindlimb model further supported the model's reliability. A sensitivity analysis performed on both the force-generating parameters and muscle's attachment points of the model indicated that the maximal isometric muscle moment is generally most sensitive to changes in either tendon slack length or the coordinates of insertion, although the degree to which the moment is affected depends on several factors. This model represents the first step in the creation of a fully dynamic 3D computer model of the mouse hindlimb and pelvis that has application to neuromuscular disease, comparative biomechanics and the neuromechanical basis of movement. Capturing the morphology and dynamics of the limb, it enables future dissection of the complex interactions between the nervous and musculoskeletal systems as well as the environment.
Anharmonic oscillation effect on the Davydov-Scott monomer in thermal bath
Creators: name: Sulaiman, A.
name: Zen, F. P.
name: Alatas, H.
name: Handoko, L. T.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The dynamics of Davydov-Scott monomer in a thermal bath with higher order amide-site's displacement leads to anharmonic oscillation effect is investigated using full-quantum approach and the Lindblad formulation of master equation. The specific heat is calculated based on the thermodynamic partition function using the path integral method. The temperature dependence of the specific heat is studied. In the model the specific heat anomaly as pointed out in recent works by Ingold et.al is also observed. However it is found that the anomaly occurs at high temperature region, and the anharmonic oscillation restores the positivity of specific heat.
description: 11 pages, 5 figures
Returning to place : the return migration of young adults to Tasmania
Creators: name: Easthope, H
Publisher: name: University Of Tasmania
Year: 2023

description: Traditionally migration scholarship has been concerned with the question of why people migrate. This has lead many migration researchers to search for lists of causal factors understood to influence migration decisions. More recent migration research has come to recognize that to understand why people migrate, it is important to look beyond such lists and attempt to provide a more complex and nuanced account of the migration process. This thesis draws upon these more recent studies and begins with the premise that to begin to answer the question of why people migrate, one must first try to comprehend how people negotiate, experience and understand their migrations. Through a study of the return migration of young adults to the state of Tasmania in Australia, this thesis discusses the utility of the concepts of 'mobility' and 'place' for exploring the complexities of people's negotiations, experiences and understandings of migration. Interviews and focus groups were conducted with thirty young adults (aged between twenty and thirty-eight) who had left Tasmania and subsequently returned. The thesis speaks to discussions surrounding the emigration of young adults and concerns about 'brain drain' occurring in many regions in Australia as well as internationally. The choice of Tasmania as a case study for this research is highly appropriate, as concerns surrounding the out-migration of young people from the state have influenced the State's social, economic and political life since the early 1900s. By examining return migration, the focus is shifted away from discourses that bemoan the negative effects of the emigration of young adults, instead recognising that migration can also bring benefits to both young migrants themselves and to the places they move between. The research found that people's experiences of migration were intricately tied to their negotiations and understandings of places. Through a complex analysis of constructions of mobility, place and belonging, the thesis reveals that young Tasmanians retain deep emotional and social connections to Tasmania at all stages of the migration process. These connections are influenced by constructions of Tasmania as a place that is understood simultaneously as 'bounded and insular' and as 'networked'. The thesis concludes by pointing to the implications of both mobility and place construction for the politics and economies of the places migrants move between, as well as for the practical considerations and identity constructions of the migrants themselves, and reasserts the importance of these concepts for studies of migration.
The mass ratio and the orbital parameters of the sdOB binary AA Doradus
Creators: name: Rucinski, Slavek M.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The time sequence of 105 spectra covering one full orbital period of AA Dor has been analyzed. Direct determination of Vsini for the sdOB component from 97 spectra outside of the eclipse for the lines MgII 4481 A and SiIV 4089 A clearly indicated a substantially smaller value than estimated before. Detailed modelling of line profile variations for 8 spectra during the eclipse for the MgII 4481 A line, combined with the out-of-eclipse fits, gave Vsini = 31.8+/-1.8 km/s. The previous determinations of Vsini, based on the HeII 4686 A line, appear to be invalid because of the large natural broadening of the line. With the assumption of the solid-body, synchronous rotation of the sdOB primary, the measured values of the semi-amplitude K1 and Vsini lead to the mass ratio q = 0.213+/-0.013 which in turn gives K2 and thus the masses and radii of both components. The sdOB component appears to be less massive than assumed before, M1 = 0.25+/-0.05 Msol, but the secondary has its mass-radius parameters close to theoretically predicted for a brown dwarf, M2 = 0.054+/-0.010 Msol and R2 = 0.089+/-0.005 Rsol. Our results do not agree with the recent determination of Vuckovic et al. 2008 based on a K2 estimate from line-profile asymmetries.
description: Accepted by MNRAS
The fast Newtonian limit for perfect fluids
Creators: name: Oliynyk, Todd A.
Publisher: name: arXiv
Year: 2009
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We prove the existence of a large class of dynamical solutions to the Einstein-Euler equations for which the fluid density and spatial three-velocity converge to a solution of the Poisson-Euler equations of Newtonian gravity. The results presented here generalize those of \cite{Oli06} to allow for a larger class of initial data. As in \cite{Oli06}, the proof is based on a non-local symmetric hyperbolic formulation of the Einstein-Euler equations which contain a singular parameter $\ep=v_T/c$ with $v_T$ a characteristic speed associated to the fluid and $c$ the speed of light. Energy and dispersive estimates on weighted Sobolev spaces are the main technical tools used to analyze the solutions in the singular limit $\ep\searrow 0$.
description: Typos corrected. Style file changed to ATMP
Parallelization of the AAE algorithm
Creators: name: Hameed, A
Publisher: name: University Of Tasmania
Year: 2023

description: The exact algorithm formulated by Kececioglu and Starrett (2004) provides a solution to the NP-complete problem of aligning alignments in most biological cases. This work investigates potential speedups that may be gained through the parallelization of the dynamic programming phase of this particular algorithm. Results indicate it is possible to improve the run time performance of the algorithm over non-trivial alignments that compose to a matrix of greater than 10^5 cells.
Probing the ATIC peak in the cosmic-ray electron spectrum with H.E.S.S
Creators: name: Collaboration, H. E. S. S.
name: :
name: Aharonian, F.
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The measurement of an excess in the cosmic-ray electron spectrum between 300 and 800 GeV by the ATIC experiment has - together with the PAMELA detection of a rise in the positron fraction up to 100 GeV - motivated many interpretations in terms of dark matter scenarios; alternative explanations assume a nearby electron source like a pulsar or supernova remnant. Here we present a measurement of the cosmic-ray electron spectrum with H.E.S.S. starting at 340 GeV. While the overall electron flux measured by H.E.S.S. is consistent with the ATIC data within statistical and systematic errors, the H.E.S.S. data exclude a pronounced peak in the electron spectrum as suggested for interpretation by ATIC. The H.E.S.S. data follow a power-law spectrum with spectral index of 3.0 +- 0.1 (stat.) +- 0.3 (syst.), which steepens at about 1 TeV.
description: 4 pages, 3 figures, Fermi data included, explanation added
Extracting functional trends from whole genome duplication events using comparative genomics
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2016
Subjects: subject: 0604 Genetics
subject: Biotechnology
subject: Genetics
subject: FOS: Biological sciences
subject: Human Genome
subject: Generic Health Relevance

description: © 2016 Hermansen et al. Background: The number of species with completed genomes, including those with evidence for recent whole genome duplication events has exploded. The recently sequenced Atlantic salmon genome has been through two rounds of whole genome duplication since the divergence of teleost fish from the lineage that led to amniotes. This quadrupoling of the number of potential genes has led to complex patterns of retention and loss among gene families. Results: Methods have been developed to characterize the interplay of duplicate gene retention processes across both whole genome duplication events and additional smaller scale duplication events. Further, gene expression divergence data has become available as well for Atlantic salmon and the closely related, pre-whole genome duplication pike and methods to describe expression divergence are also presented. These methods for the characterization of duplicate gene retention and gene expression divergence that have been applied to salmon are described. Conclusions: With the growth in available genomic and functional data, the opportunities to extract functional inference from large scale duplicates using comparative methods have expanded dramatically. Recently developed methods that further this inference for duplicated genes have been described.
Targeting immune response with therapeutic vaccines in premalignant lesions and cervical cancer: hope or reality from clinical studies
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2016
Subjects: Human papillomavirus
cervical cancer
cervical intraepithelial neoplasia
therapeutic vaccines
immunotherapy

description: © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Human papillomavirus (HPV) is widely known as a cause of cervical cancer (CC) and cervical intraepithelial neoplasia (CIN). HPVs related to cancer express two main oncogenes, i.e. E6 and E7, considered as tumorigenic genes; their integration into the host genome results in the abnormal regulation of cell cycle control. Due to their peculiarities, these oncogenes represent an excellent target for cancer immunotherapy. In this work the authors highlight the potential use of therapeutic vaccines as safe and effective pharmacological tools in cervical disease, focusing on vaccines that have reached the clinical trial phase. Many therapeutic HPV vaccines have been tested in clinical trials with promising results. Adoptive T-cell therapy showed clinical activity in a phase II trial involving advanced CC patients. A phase II randomized trial showed clinical activity of a nucleic acid-based vaccine in HPV16 or HPV18 positive CIN. Several trials involving peptide-protein-based vaccines and live-vector based vaccines demonstrated that these approaches are effective in CIN as well as in advanced CC patients. HPV therapeutic vaccines must be regarded as a therapeutic option in cervical disease. The synergic combination of HPV therapeutic vaccines with radiotherapy, chemotherapy, immunomodulators or immune checkpoint inhibitors opens a new and interesting scenario in this disease.
Robotic Vision By Using Bee Algorithm
Creators: name: Zhou, L
Publisher: name: University Of Tasmania
Year: 2023

description: With the development of technologies, robots have played an important role in many fields of the society. They help people to deal with a large amount of work, especially operate in the extremely dangerous environment instead of people. For a robot, effective obstacle avoidance is still a challenge in the development of robot. The existing systems sometimes combine with multi-devices to conquer this challenge so that the expensive cost has been as a negative factor that cumbers the application of robot. For this purpose, find a way with the low equipment requirement but still having the high accuracy is essential. Optic flow as another algorithm coming from bee vision has been used to help robots avoid obstacles for many years. And it owns many advantages. This study presents a system based on the optic flow is developed to avoid obstacle in the view-field of the robot. The main point in this thesis is to show how the system works under an assumed environment for robot navigation, and compare the results to Thomas' to see whether the low equipment requirement can also achieve the purpose of avoiding obstacles.
Primordial Non-Gaussianities from Inflation Models
Creators: name: Chen, Xingang
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: This is a pedagogical review on primordial non-Gaussianities from inflation models. We introduce formalisms and techniques that are used to compute such quantities. We review different mechanisms which can generate observable large non-Gaussianities during inflation, and distinctive signatures they leave on the non-Gaussian profiles. They are potentially powerful probes to the dynamics of inflation. We also provide a non-technical and qualitative summary of the main results and underlying physics.
description: 84 pages, invited review for special issue of Advances in Astronomy on "Testing the Gaussianity and Statistical Isotropy of the Universe"; v3, various improvement and corrections, especially in Sec.6.4, 8.1 & 9.2
Supplementary document for Imaging objects hidden inside the strong scattering media based on bidirectional ghost imaging - 6745731.pdf
Creators: name: zhang, dejin
name: Sheng, Wei
name: Shi, Yaoyao
name: Liu, Youwen
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: Uncategorized

description: Deconvolttion by the modeled PSF
Fitting the dielectric response of collisionless plasmas by continued fractions
Creators: name: Wierling, August
Publisher: name: arXiv
Year: 2009
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: We present an approximation scheme for the dielectric response of thermal collisionless plasmas at arbitrary degeneracy. A T-fraction representation is obtained from the known expansions of the real part of the dielectric function for small and large arguments. The partial numerators and denominators of the continued fraction are generated by a modified Q-D algorithm. For several typical values of the degeneracy parameter $θ$, extensive tables for the expansion coefficients and the partial numerators and denominations are given allowing for an easy implementation of the fitting function. Also, an error analysis is performed.
Force generation by membrane-associated myosin-I
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2016
Subjects: Actin Cytoskeleton
Actins
Animals
Biomechanical Phenomena
Cell Membrane
Computer Simulation
Diffusion
Lipids
Mice
Models, Molecular
Myosin Type I
Optical Tweezers
Protein Transport

description: Vertebrate myosin-IC (Myo1c) is a type-1 myosin that links cell membranes to the cytoskeleton via its actin-binding motor domain and its phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P 2)-binding tail domain. While it is known that Myo1c bound to PtdIns(4,5)P 2 in fluid-lipid bilayers can propel actin filaments in an unloaded motility assay, its ability to develop forces against external load on actin while bound to fluid bilayers has not been explored. Using optical tweezers, we measured the diffusion coefficient of single membrane-bound Myo1c molecules by force-relaxation experiments, and the ability of ensembles of membrane-bound Myo1c molecules to develop and sustain forces. To interpret our results, we developed a computational model that recapitulates the basic features of our experimental ensemble data and suggests that Myo1c ensembles can generate forces parallel to lipid bilayers, with larger forces achieved when the myosin works away from the plane of the membrane or when anchored to slowly diffusing regions.
A queueing theory description of fat-tailed price returns in imperfect financial markets
Creators: name: Lamba, H.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Trading and Market Microstructure (q-fin.TR)
subject: FOS: Economics and business

description: In a financial market, for agents with long investment horizons or at times of severe market stress, it is often changes in the asset price that act as the trigger for transactions or shifts in investment position. This suggests the use of price thresholds to simulate agent behavior over much longer timescales than are currently used in models of order-books. We show that many phenomena, routinely ignored in efficient market theory, can be systematically introduced into an otherwise efficient market, resulting in models that robustly replicate the most important stylized facts. We then demonstrate a close link between such threshold models and queueing theory, with large price changes corresponding to the busy periods of a single-server queue. The distribution of the busy periods is known to have excess kurtosis and non-exponential decay under various assumptions on the queue parameters. Such an approach may prove useful in the development of mathematical models for rapid deleveraging and panics in financial markets, and the stress-testing of financial institutions.
Mechanism of Ribonuclease III Catalytic Regulation by Serine Phosphorylation
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2016
Subjects: Bacteriophage T7
Escherichia coli
Escherichia coli Proteins
Hydrolysis
Kinetics
Molecular Dynamics Simulation
Phosphorylation
Protein Kinases
Protein Processing, Post-Translational
RNA
Ribonuclease III
Serine

description: Ribonuclease III (RNase III) is a conserved, gene-regulatory bacterial endonuclease that cleaves double-helical structures in diverse coding and noncoding RNAs. RNase III is subject to multiple levels of control, reflective of its global regulatory functions. Escherichia coli (Ec) RNase III catalytic activity is known to increase during bacteriophage T7 infection, reflecting the expression of the phage-encoded protein kinase, T7PK. However, the mechanism of catalytic enhancement is unknown. This study shows that Ec-RNase III is phosphorylated on serine in vitro by purified T7PK, and identifies the targets as Ser33 and Ser34 in the N-terminal catalytic domain. Kinetic experiments reveal a 5-fold increase in k cat and a 1.4-fold decrease in Km following phosphorylation, providing a 7.4-fold increase in catalytic efficiency. Phosphorylation does not change the rate of substrate cleavage under single-turnover conditions, indicating that phosphorylation enhances product release, which also is the rate-limiting step in the steady-state. Molecular dynamics simulations provide a mechanism for facilitated product release, in which the Ser33 phosphomonoester forms a salt bridge with the Arg95 guanidinium group, thereby weakening RNase III engagement of product. The simulations also show why glutamic acid substitution at either serine does not confer enhancement, thus underscoring the specific requirement for a phosphomonoester.
The Need for Bridging the Gaps Between Theory and Practice: An Authority's Perspective in Some Identified Areas
Creators: name: Cromnier, Nina
name: Almén, Anja
name: Cederlund, Torsten
name: Hofvander, Peter
name: Johansson, Jan
name: Wiklund, Åsa
Publisher: name: Zenodo
Year: 2021
Subjects: medical applications
emergency preparedness
concept of risk
protection of the environment

description: The paper ”Keeping the ICRP recommendations fit for purpose” contains a wide variety of issues which ICRP believes merit attention in the up-coming revision process. The Swedish Radiation Safety Authority (SSM) supports ICRP on a number of issues mentioned in the article and believes it to be a valuable starting point for the international discussion. SSM considers the present system of radiological protection to be robust and in most cases fit for purpose. However, based on experience gained from implementing and using the recommendations in regulatory work, SSM has identified a need for clarifications and possible adjustments. SSM finds the fundamentals of the ICRP recommendation elaborated and clarified in a number of exposure situations, but to a lesser extent in medical exposure situations. The ICRP recommendations published for specific medical practices are many and valuable for practical use, but there is a gap between practice and theory. It is important to close this gap and fully integrate medical exposures into the system in order to remain relevant in this area. The ICRP recommendations for nuclear or radiological emergencies could benefit from further review and guidance, in particular concerning exposure situations, reference levels, informed consent for emergency workers, and categorization of workers involved in recovery activities. In recent years, SSM has developed new regulations on the design and operation of nuclear power reactors, which also include a co-regulation of nuclear safety and radiation protection. One of the challenges in this work has been to establish specific criteria of acceptability on radiation risk for workers (potential exposure), and how these criteria should be related to requirements on optimization of radiation protection and safety and dose limitation in normal operation. SSM believes that there is a need for further guidance from ICRP on how to apply risk constraints for workers, and especially in situations involving both nuclear safety and radiation protection. The health and status of the ecosystem should be protected while the system for protection today only applies to reference organisms, SSM therefore thinks there may be a need to further develop the system for environmental protection in order to also reflect the protection of ecosystem services. SSM would also like to address the issue of veterinary patients (animals), where SSM calls for a more in-depth discussion of the ethical and scientific background to include veterinary patients.
description: License: Creative Commons Attribution Non Commercial No Derivatives 2.5 Generic Grants: I would like to leave it blank.
Photoproduction of pions and properties of baryon resonances from a Bonn-Gatchina partial wave analysis
Creators: name: Anisovich, A. V.
name: Klempt, E.
name: Nikonov, V. A.
name: Matveev, M. A.
name: Sarantsev, A. V.
name: Thoma, U.
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Masses, widths and photocouplings of baryon resonances are determined in a coupled-channel partial wave analysis of a large variety of data. The Bonn-Gatchina partial wave formalism is extended to include a decomposition of t- and u-exchange amplitudes into individual partial waves. The multipole transition amplitudes for $γp\to pπ^0$ and $γp\to nπ^+$ are given and compared to results from other analyses.
description: 18 pages, 14 figures
Additional file 1 of CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in huntington’s disease
Creators: name: Yu, Dahyun
name: Zarate, Nicole
name: White, Angel
name: Coates, De’jah
name: Tsai, Wei
name: Nanclares, Carmen
name: Cuccu, Francesco
name: Yue, Johnny S.
name: Brown, Taylor G.
name: Mansky, Rachel H.
name: Jiang, Kevin
name: Kim, Hyuck
name: Nichols-Meade, Tessa
name: Larson, Sarah N.
name: Gundry, Katherine
name: Zhang, Ying
name: Tomas-Zapico, Cristina
name: Lucas, Jose J.
name: Benneyworth, Michael
name: Öz, Gülin
name: Cvetanovic, Marija
name: Araque, Alfonso
name: Gomez-Pastor, Rocio
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1. Depletion of MSN marker expression does not reflect neuronal loss in zQ175 mice. a, Representative images of EM48 immunostaining in the dorsal striatum and cortex of zQ175 at 3, 6, 12 and 22 months (n=6 mice/genotype, 6-9 images averaged/mouse). b, Quantification of the number of EM48 aggregates in the cortex of zQ175 and its comparison with striatum. c, Representative images of NeuN immunostaining in the dorsal striatum of WT and zQ175 at 3, 6, 12 and 22 months (n=3 mice/genotype). d, e, Representative images of Ctip2 immunostaining in the dorsal striatum of 12 months old WT and zQ175 and quantitative analysis of Ctip2+ cells (n = 3 WT; 3 zQ175, 9 images averaged/mouse). Scale bar, 50 µm. DAPI is used for nuclear staining. f, Cresyl violet staining in the dorsal striatum of 22 months old WT and zQ175 mice. Magnified image represents neurons (white arrow) and glial (black arrow) cells. g, Quantification of neurons from cresyl violet analyses at 12 and h, 22 months old WT and zQ175 mice (3 mice/genotype, 3 images averaged/mouse). i, Dotted line on magnetic resonance images displays the manually traced striatum region of representative mice of each genotype at 22 months of age. j, Striatum volume analyzed in 22-month-old mice from images in G (n=4 mice/genotype, at least 3 images averaged/mouse). Error bars denote mean ± SD. Student’s t-test, p-values <0.05 are indicated. n.s = not significant.
Shipbuilding as Romantic Abstraction
Creators: name: Bissland, JM
Publisher: name: University Of Tasmania
Year: 2023

description: The object and primary aim of this MFA project was to create a body of photographic images that combine the notion of maritime romance with the practicalities of shipbuilding. The images are visual evidence relating to personal experience and as such are reflective in content. As a photographic artist my intention and motivation was to gain a thorough and intense command and understanding of my chosen medium in terms of theory, concept, practice and skill. My investigation process is informed by years of experience in both shipbuilding and photography. It involved experimentation into processes and materials in order that the viewer is informed of an aesthetic notion through visual stimuli. In order that I engage with the broader photographic history by means of abstraction, highlighting the aesthetic and that I gain insight into a broaden aesthetic, I studied extracts from the works of philosophers such as Russell, Heidegger, Merleau-Ponty and artist such as Motherwell and Rothko. Conceptually, the body of work, resulting from my examination, is a combination of photographic images that are indicative of the shipbuilding environment. My intention is to draw the viewer into the world of the shipbuilder; to question the very notion of romance when related to shipbuilding. From a practical standpoint I have explored new territories in film and paper development, and revisited some old ones in order that the images attain their optimum potential within the confines of practicality. My intention was to show that romance may exist in shipbuilding but it is romance built around hard work on hard materials in a hard environment and as such is not for the faint hearted.
More than meets the eye: The merging of perceptual and conceptual knowledge in the anterior temporal face area
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2016
Subjects: face processing
anterior temporal lobes
semantic memory
perception
multivoxel pattern analysis

description: © 2016 Collins, Koski and Olson. An emerging body of research has supported the existence of a small face sensitive region in the ventral anterior temporal lobe (ATL), referred to here as the “anterior temporal face area”. The contribution of this region in the greater face-processing network remains poorly understood. The goal of the present study was to test the relative sensitivity of this region to perceptual as well as conceptual information about people and objects. We contrasted the sensitivity of this region to that of two highlystudied face-sensitive regions, the fusiform face area (FFA) and the occipital face area (OFA), as well as a control region in early visual cortex (EVC). Our findings revealed that multivoxel activity patterns in the anterior temporal face area contain information about facial identity, as well as conceptual attributes such as one’s occupation. The sensitivity of this region to the conceptual attributes of people was greater than that of posterior face processing regions. In addition, the anterior temporal face area overlaps with voxels that contain information about the conceptual attributes of concrete objects, supporting a generalized role of the ventral ATLs in the identification and conceptual processing of multiple stimulus classes.
Finding critical points using improved scaling Ansaetze
Creators: name: Roncaglia, M.
name: Venuti, L. Campos
name: Boschi, C. Degli Esposti
Publisher: name: arXiv
Year: 2008
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Theory (hep-th)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Analyzing in detail the first corrections to the scaling hypothesis, we develop accelerated methods for the determination of critical points from finite size data. The output of these procedures are sequences of pseudo-critical points which rapidly converge towards the true critical points. In fact more rapidly than previously existing methods like the Phenomenological Renormalization Group approach. Our methods are valid in any spatial dimensionality and both for quantum or classical statistical systems. Having at disposal fast converging sequences, allows to draw conclusions on the basis of shorter system sizes, and can be extremely important in particularly hard cases like two-dimensional quantum systems with frustrations or when the sign problem occurs. We test the effectiveness of our methods both analytically on the basis of the one-dimensional XY model, and numerically at phase transitions occurring in non integrable spin models. In particular, we show how a new Homogeneity Condition Method is able to locate the onset of the Berezinskii-Kosterlitz-Thouless transition making only use of ground-state quantities on relatively small systems.
description: 16 pages, 4 figures. New version including more general Ansaetze basically applicable to all cases
Deconfinement Phase Transition in Compact Stars : Maxwell vs. Gibbs Construction of the Mixed Phase
Creators: name: Bhattacharyya, Abhijit
name: Mishustin, Igor N.
name: Greiner, Walter
Publisher: name: arXiv
Year: 2009
Subjects: subject: Nuclear Theory (nucl-th)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study different realisations of the first order deconfinement phase transition inside a compact star by comparing the Gibbs and Maxwell construction for the mixed phase. The hadronic sector is described within the relativistic mean field model including hyperons. The quark sector is described by the MIT Bag model. We find that these two realisations lead to very different star properties, in particular, the composition of the stellar matter. We also find that for the Maxwell construction there is a sharp discontinuity in the baryon density and the electron chemical potential. We argue that a sharp jump in the elctron chemical potential should lead to the redistribution of electrons and formation of strong electric fields around the discontinuity surface.
description: 10 pages
EVIDENCIA SOBRE LOS HÁBITOS DEL SUEÑO PREDOMINANTES Y FACTORES QUE AFECTAN LA HIGIENE DEL SUEÑO EN NIÑOS PREESCOLARES/ESCOLARES.
Creators: name: Salazar Peña, Constanza Andrea
name: Parra, Roberto
name: Sepulveda Jimenez, Karla Constanza
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 420599
subject: Nursing not elsewhere classified

description: El sueño es fundamental para el bienestar general de los niños y el desarrollo cognitivo, emocional y físico. Al conocer los hábitos de sueño predominantes, se puede determinar si estos niños están obteniendo la cantidad adecuada de sueño y si existe algún factor que pueda afectar su sueño. Por otro lado, los hábitos de sueño pueden tener un impacto significativo en el bienestar general de los niños.
Superfluidity of Interacting Bosonic Mixtures in Optical Lattices
Creators: name: Gadway, Bryce
name: Pertot, Daniel
name: Reimann, René
name: Schneble, Dominik
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We report the observation of many-body interaction effects for a homonuclear bosonic mixture in a three-dimensional optical lattice with variable state dependence along one axis. Near the superfluid-to-Mott insulator transition for one component, we find that the presence of a second component can reduce the apparent superfluid coherence, most significantly when it either experiences a strongly localizing lattice potential or none at all. We examine this effect by varying the relative populations and lattice depths, and discuss the observed behavior in view of recent proposals for scattering from impurities and of atom-phonon coupling for atoms immersed in a superfluid.
description: 4 pages, 3 figures
The case of the three paintings by Wang Meng
Creators: name: Griffin, Helen Wodehouse
Publisher: name: University of British Columbia
Year: 2011

description: The problem in this thesis is to find out which of three of (the Chinese fourteenth Century painter) Wang Meng's paintings in the Palace Collection in Taiwan, is the original or "least-corrupted" and which the copies. They are hanging scrolls, ink and slight colour on paper, approximately four feet by two feet titled Hua-ch'i yü-yin. The aim is to show that by using Western scientific art history analysis some advance is possible; and the results may help in establishing pivot points, called here "prime objects", necessary for establishing a history of styles for Chinese painting. Materials used were photographs taken by the University of Michigan, Department of History of Art in 1965-6 in Taipei, Taiwan. Methods used were those standard for western art historians, adapted for Chinese paintings and now being put into practice by Professor Wen Fong of Princeton. Data was gathered from translations of ancient critics in China by 0. Siren and discussions of these by Sherman Lee, James Cahill, Richard Edwards and others. But most important was a detailed, energetic and time consuming study of the reproductions of the three paintings, and the application of Professor Wen Fong's reasoning to this study. It was found that internal, painting-style, analysis was supported by external, colophon-seal findings, to give a more convincing result. Results showed that A is most likely to be the original while B is probably a forgery of A and C a "free" copy of B.
Multiple vortex-antivortex pair generation in magnetic nanodots
Creators: name: Gaididei, Yuri
name: Kravchuk, Volodymyr P.
name: Sheka, Denis D.
name: Mertens, Franz G.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The interaction of a magnetic vortex with a rotating magnetic field causes the nucleation of a vortex--antivortex pair leading to a vortex polarity switching. The key point of this process is the creation of a dip, which can be interpreted as a nonlinear resonance in the system of certain magnon modes with nonlinear coupling. The usually observed single-dip structure is a particular case of a multidip structure. The dynamics of the structure with $n$ dips is described as the dynamics of nonlinearly coupled modes with azimuthal numbers $m=0,\pm n,\pm 2n$. The multidip structure with arbitrary number of vortex antivortex pairs can be obtained in vortex-state nanodisk using a space- and time-varying magnetic field. A scheme of a possible experimental setup for multidip structure generation is proposed.
description: 12 pages, 7 figures
Automorphisms of cotangent bundles of Lie groups
Creators: name: Diatta, Andre
name: Manga, Bakary
Publisher: name: arXiv
Year: 2008
Subjects: subject: Differential Geometry (math.DG)
subject: Group Theory (math.GR)
subject: FOS: Mathematics
subject: 22C05, 22E60, 22E15, 22E10

description: Let G be a Lie group, $T^*G$ its cotangent bundle with its natural Lie group structure obtained by performing a left trivialization of T^*G and endowing the resulting trivial bundle with the semi-direct product, using the coadjoint action of G on the dual space of its Lie algebra. We investigate the group of automorphisms of the Lie algebra of $T^*G$. More precisely, amongst other results, we fully characterize the space of all derivations of the Lie algebra of $T^*G$. As a byproduct, we also characterize some spaces of operators on G amongst which, the space J of bi-invariant tensors on G and prove that if G has a bi-invariant Riemannian or pseudo-Riemannian metric, then J is isomorphic to the space of linear maps from the Lie algebra of G to its dual space which are equivariant with respect to the adjoint and coadjoint actions, as well as that of bi-invariant bilinear forms on G. We discuss some open problems and possible applications.
description: V2: 27 pages, Latex, a few minor results added and the paper layout reorganised. The last version appeared at Afr. Diaspora J. Math