cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Management of Acute Non-Infectious Anterior Uveitis in Adults – Practice Patterns Among Uveitis Specialists in North America
Creators: name: Zhang, Howard
name: Nicholson, Crystal M.
name: Kempen, John H.
name: Ying, Gui-Shuang
name: Gangaputra, Sapna S.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: This study aims to understand the practice patterns among ophthalmologists in North America who manage patients with acute, non-infectious anterior uveitis. An eight-question survey was designed to elucidate the practice patterns of ophthalmologists across various geographic locations and practice settings regarding the management of anterior uveitis. This survey was distributed via the American Uveitis Society and Young Uveitis Specialists email listserv to ophthalmologists who self-identify as uveitis specialists and have a patient population that is at least 30% uveitis. A total of 102 responses were received and analyzed (37% response rate). Respondents practiced predominantly in North America, and 40% had received subspecialty training in uveitis. All respondents chose topical corticosteroid therapy as first-line treatment for acute, unilateral, or bilateral non-infectious idiopathic anterior uveitis. The most common initial frequency for prednisolone acetate administration was six times/day while the patient was awake (29.7%) and patients are typically seen in follow-up within a week (75% of respondents). If there is a lack of treatment response within 2–3 weeks with the initial topical treatment, 42 respondents (41.2%) chose to switch to difluprednate eye drops and 29 (28.4%) recommended switching to oral prednisone. Our results show that topical corticosteroid, most frequently prednisolone acetate 1%, is the treatment of choice for patients with acute noninfectious anterior uveitis. Reported initial medication dosing and follow-up care approaches are highly variable, which suggests heterogeneity in practice patterns. Further research on the optimal initial dosing is needed.
Effect of heavy metal exposures on hearing loss among shipyard personnel
Creators: name: Schaal, Nicholas
name: Slagley, Jeremy
name: Zreiqat, Majed
name: Paschold, Helmut
name: T. Cekada
Publisher: name: F1000Research
Year: 2017

description: Objectives: Evaluate the association between exposures to metals on hearing loss in Shipyard personnel while controlling for noise, organic solvents, and other major risk factors.

Methods: Data for 1,546 personnel aged 18-77 from the years 2004-2015 were analyzed. Hearing threshold changes were analyzed across the 500-6000 Hertz (Hz) frequencies to identify development of a Permanent Threshold Shift (PTS). Hearing change was assessed by subtracting each subject’s initial hearing threshold at the beginning of the 11 year time frame from subject’s final hearing threshold at the end of the timeframe. Noise and chemical exposure records were used to assign personnel into one of five exposure groups based on level of concentration: high noise, high metals/solvents, high metals/noise, high metals/solvents/noise, and low metals/solvents/noise. Specific chemicals targeted for analysis included lead, cadmium, arsenic, toluene and xylene. Personal protective equipment (PPE) use information was not collected but personnel were expected to be compliant with PPE requirements implemented by the organization.

Results: Logistic regression indicated high concentrations of metals and solvents had an Odds Ratio (OR) = 2.4 and 95% Confidence Interval (CI) 1.02, 2.85. The metals, solvents, and noise group had an OR=1.7; 95% CI 1.46, 3.94. Both groups were significantly associated with development of a PTS while controlling for the effects of age, gender and exposure duration.

Conclusions: Personnel with simultaneous exposures to high concentrations of metals such as lead, cadmium, and arsenic and solvents such as toluene and xylene beginning at concentrations less than OSHA’s Permissible Exposure limits may damage hearing. Results suggest the need to consider expanding hearing conservation programs beyond just noise exposed workers by considering combinations of exposures to metals, solvents, and noise.
Risk Factors for Progression of Graft Rejection to Graft Failure Following Penetrating Keratoplasty
Creators: name: Shalaby, Wesam Shamseldin
name: Shiuey, Eric J.
name: Patel, Tejal M.
name: Rapuano, Christopher J.
name: Syed, Zeba A.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Marine Biology
subject: Science Policy
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: To analyze the risk factors for graft failure in eyes with endothelial graft rejection following penetrating keratoplasty (PK). Single-center, retrospective study that included patients who underwent PK at Wills Eye Hospital (2007–2018) who later presented with endothelial graft rejection, defined as clinical appearance of keratic precipitates or anterior chamber reaction. Among patients with rejection across multiple grafts, only the first PK of the first eye with documented rejection was included. The primary outcome measures were progression to graft failure, defined as irreversible and visually significant stromal edema, haze, or scarring, and acute graft failure, defined as failure within 6 months of rejection. 296 eyes from 296 patients were included with mean age of 54.4 ± 21.3 years. Average follow-up duration was 4.5 ± 2.9 years and rejection occurred 16.2 ± 18.7 months after transplantation. The rate of graft failure was 45.9% and the rate of acute failure was 31.4%. Predictors of failure after rejection included history of systemic autoimmune disorders (OR = 8.99, 95% CI = 2.03–39.77, p = 0.004), prior glaucoma surgery (OR = 2.73, 95% CI = 1.05–7.11, p = 0.039), and postoperative lens status as aphakia (OR = 7.59, 95% CI = 1.00–57.52, p = 0.0497). Predictors of acute graft failure after rejection included history of systemic autoimmune disorders (OR = 4.69, 95% CI = 1.20–18.33, p = 0.026), active microbial infection (OR = 3.52, 95% CI = 1.69–7.31, p = 0.001), and prior glaucoma surgery (OR = 3.50, 95% CI = 1.42–8.62, p = 0.006). Systemic autoimmune disorders and prior glaucoma surgery predicted both overall and acute graft failure, suggesting more aggressive rejection episodes in these cohorts.
Dual targeting of FGFR3 and ERBB3 enhances the efficacy of FGFR inhibitors in FGFR3 fusion-driven bladder cancer
Creators: name: Weickhardt, Andrew
name: Lau, David Kar Wah
name: Hodgson-Garms, Margeaux
name: Lavis, Austin
name: Jenkins, Laura
name: Vukelic, Natalia
name: Ioannidis, P
name: Luk, Ian
name: Mariadason, John
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 321199
subject: Oncology and carcinogenesis not elsewhere classified

description: BACKGROUND: Mutations and fusions in Fibroblast Growth Factor Receptor 3 (FGFR3) occur in 10-20% of metastatic urothelial carcinomas and confer sensitivity to FGFR inhibitors. However, responses to these agents are often short-lived due to the development of acquired resistance. The objective of this study was to identify mechanisms of resistance to FGFR inhibitors in two previously uncharacterised bladder cancer cell lines harbouring FGFR3 fusions and assess rational combination therapies to enhance sensitivity to these agents. METHODS: Acquired resistance to FGFR inhibitors was generated in two FGFR3 fusion harbouring cell lines, SW780 (FGFR3-BAIAP2L1 fusion) and RT4 (FGFR3-TACC3 fusion), by long-term exposure to the FGFR inhibitor BGJ398. Changes in levels of receptor tyrosine kinases were assessed by phospho-RTK arrays and immunoblotting. Changes in cell viability and proliferation were assessed by the Cell-Titre Glo assay and by propidium iodide staining and FACS analysis. RESULTS: Long term treatment of FGFR3-fusion harbouring SW780 and RT4 bladder cancer cell lines with the FGFR inhibitor BGJ398 resulted in the establishment of resistant clones. These clones were cross-resistant to the clinically approved FGFR inhibitor erdafitinib and the covalently binding irreversible FGFR inhibitor TAS-120, but remained sensitive to the MEK inhibitor trametinib, indicating resistance is mediated by alternate activation of MAPK signalling. The FGFR inhibitor-resistant SW780 and RT4 lines displayed increased expression of pERBB3, and strikingly, combination treatment with an FGFR inhibitor and the ATP-competitive pan-ERBB inhibitor AZD8931 overcame this resistance. Notably, rapid induction of pERBB3 and reactivation of pERK also occurred in parental FGFR3 fusion-driven lines within 24 h of FGFR inhibitor treatment, and combination treatment with an FGFR inhibitor and AZD8931 delayed the reactivation of pERBB3 and pERK and synergistically inhibited cell proliferation. CONCLUSIONS: We demonstrate that increased expression of pERBB3 is a key mechanism of adaptive resistance to FGFR inhibitors in FGFR3-fusion driven bladder cancers, and that this also occurs rapidly following FGFR inhibitor treatment. Our findings demonstrate that resistance can be overcome by combination treatment with a pan-ERBB inhibitor and suggest that upfront combination treatment with FGFR and pan-ERBB inhibitors warrants further investigation for FGFR3-fusion harbouring bladder cancers.
Combined metal, solvent, and noise exposure effects on permanent threshold shifts
Creators: name: Schaal, Nicholas Cody
name: Slagley, Jeremy
name: Majad Zreiqat
name: Paschold, Helmut
Publisher: name: F1000Research
Year: 2017

description: Objectives: Evaluate the association between exposures to metals on hearing loss in Shipyard personnel while controlling for noise, organic solvents, and other major risk factors.

Methods: Data for 1,546 personnel aged 18-77 from the years 2004-2015 were analyzed. Hearing threshold changes were analyzed across the 500-6000 Hertz (Hz) frequencies to identify development of a Permanent Threshold Shift (PTS). Hearing change was assessed by subtracting each subject’s initial hearing threshold at the beginning of the 11 year time frame from subject’s final hearing threshold at the end of the timeframe. Noise and chemical exposure records were used to assign personnel into one of five exposure groups based on level of concentration: high noise, high metals/solvents, high metals/noise, high metals/solvents/noise, and low metals/solvents/noise. Specific chemicals targeted for analysis included lead, cadmium, arsenic, toluene and xylene. Personal protective equipment (PPE) use information was not collected but personnel were expected to be compliant with PPE requirements implemented by the organization.

Results: Logistic regression indicated high concentrations of metals and solvents had an Odds Ratio (OR) = 2.4 and 95% Confidence Interval (CI) 1.02, 2.85. The metals, solvents, and noise group had an OR=1.7; 95% CI 1.46, 3.94. Both groups were significantly associated with development of a PTS while controlling for the effects of age, gender and exposure duration.

Conclusions: Personnel with simultaneous exposures to high concentrations of metals such as lead, cadmium, and arsenic and solvents such as toluene and xylene beginning at concentrations less than OSHA’s Permissible Exposure limits may damage hearing. Results suggest the need to consider expanding hearing conservation programs beyond just noise exposed workers by considering combinations of exposures to metals, solvents, and noise.
Survival and growth of a high-mountain daisy transplanted outside its local range, and implications for climate-induced distribution shifts
Creators: name: Sumner, Emma E
name: Morgan, John
name: Venn, Susanna E
name: Camac, James S
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 310399
subject: Ecology not elsewhere classified
classificationCode: 310899
subject: Plant biology not elsewhere classified

description: Field transplant experiments can improve our understanding of the effects of climate on distributions of plants versus a milieu of biotic factors which may be mediated by climate. We use a transplant experiment to test how survival and growth of a mountain-top daisy (Podolepis robusta), when planted within and outside its current local range, varies as a function of individual plant size, elevation, aspect and the presence of other vegetation. We expected a home-site advantage for the species, with highest survival and growth within the species' current elevational limits, and a decline in vital rates above (due to physiological limitations) and below (due to competition with near-neighbours) these limits. Transplant survival during the beginning of the census was high (89 %), though by the third growing season, 36 % of initial transplants were remaining. Elevation had a significant negative effect on individual mortality rates; plants growing at higher elevations had a lower estimated hazard rate and thus, higher survival relative to those planted at elevations below the current lower limit of the distribution. By contrast, we detected no significant effect of elevation on growth rates. Small vegetation gaps had no effect on growth rates, though we found a negative, but non-significant, effect on mortality rates. Aspect had a very strong impact on growth. Plants transplanted to cool aspects had a significantly lower growth rate relative to transplants growing on a warm aspect. Conversely, aspect was not a significant predictor of individual mortality rates. Restrictions on the local distribution of P. robusta appear to be governed by mortality drivers at lower elevation and by growth drivers associated with aspect. We highlight that our ability to understand the drivers of distributions in current and future climates will be limited if contextual- and individual-level plant responses remain understudied.
Assessment of Syphilitic Optic Neuropathy: A Prospective Cross-Sectional Study
Creators: name: Du, Kui-Fang
name: Li, Hai-Yan
name: Wang, Xiao-Dan
name: Li, Xiao-Na
name: Kong, Wen-Jun
name: Xie, Lian-Yong
name: Zhang, Ming
name: Yan, Zhen-Zhen
name: Weng, Wen-Jia
name: Dong, Hong-Wei
name: Gao, Yan-Qing
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Cell Biology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: To evaluate the clinical features of syphilis optic neuropathy (SON) and explore its underlying pathogenesis by measuring the peripapillary retinal nerve fiber layer (pRNFL). This was a prospective cross-sectional study. Syphilitics, regardless of ocular complaints, in the ophthalmology department in 2020 were screened for SON, which was defined as isolated optic neuropathy without overt signs of syphilitic uveitis. We analyzed the demographic and clinical information, including ultra-wide-field fundus photographs, fundus fluorescein angiography (FFA), and pRNFL thickness measured by spectral-domain-OCT (SD-OCT). Of 577 cases with syphilis, 25 patients (4.3% ± 0.8%) presented with optic disc edema and 7 patients (1.2% ± 0.5%) with optic atrophy. Of the eyes with optic disc edema, (35 eyes, 40% biocular), 40% had no ocular symptoms, and 45.7% had visual acuity (VA) better than 20/25, whereas 100% showed optic disc leakage in FFA. Of the eyes with optic atrophy (14 eyes, 100% biocular), 100% were male and presented severe vision impairment (VA worse than 20/70), but no optic disc leakage in FFA. A higher rapid plasma reagin (RPR) level was more frequently observed in patients with SON (p = 0.009). Additionally, the pRNFL thickness in non-ocular syphilis was not related to the RPR level or the syphilis duration (all p > 0.05). The SONs could manifest as asymptomatic optic disc edema or blinding optic atrophy, which were independent episodic reactions from ocular or cerebral syphilis, respectively. Our data highlighted the need for ophthalmic screening and prompt neurosyphilis treatment.
Do P2Y12 receptor inhibitors prescribed poststroke modify the risk of cognitive disorder or dementia? Protocol for a target trial using multiple national Swedish registries
Creators: name: Hinwood, M
name: Nyberg, J
name: Leigh, L
name: Gustavsson, S
name: Attia, J
name: Oldmeadow, C
name: Ilicic, M
name: Linden, T
name: Åberg, ND
name: Levi, C
name: Spratt, N
name: Carey, Leeanne
name: Pollack, M
name: Johnson, SJ
name: Kuhn, GH
name: Walker, FR
name: Nilsson, M
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 420699
subject: Public health not elsewhere classified

description: INTRODUCTION: The target of a class of antiplatelet medicines, P2Y12R inhibitors, exists both on platelets and on brain immune cells (microglia). This protocol aims to describe a causal (based on a counterfactual model) approach for analysing whether P2Y12R inhibitors prescribed for secondary prevention poststroke may increase the risk of cognitive disorder or dementia via their actions on microglia, using real-world evidence. METHODS AND ANALYSIS: This will be a cohort study nested within the Swedish National Health and Medical Registers, including all people with incident stroke from 2006 to 2016. We developed directed acyclic graphs to operationalise the causal research question considering potential time-independent and time-dependent confounding, using input from several experts. We developed a study protocol following the components of the target trial approach described by Hernan et al and describe the data structure that would be required in order to make a causal inference. We also describe the statistical approach required to derive the causal estimand associated with this important clinical question; that is, a time-to-event analysis for the development of cognitive disorder or dementia at 1, 2 and 5-year follow-up, based on approaches for competing events to account for the risk of all-cause mortality. Causal effect estimates and the precision in these estimates will be quantified. ETHICS AND DISSEMINATION: This study has been approved by the Ethics Committee of the University of Gothenburg and Confidentiality Clearance at Statistics Sweden with Dnr 937-18, and an approved addendum with Dnr 2019-0157. The analysis and interpretation of the results will be heavily reliant on the structure, quality and potential for bias of the databases used. When we implement the protocol, we will consider and document any biases specific to the dataset and conduct appropriate sensitivity analyses. Findings will be disseminated to local stakeholders via conferences, and published in appropriate scientific journals.
Preserflo MicroShunt Implantation for Glaucoma Secondary to Viral and Juvenile Idiopathic Arthritis-Related Anterior Uveitis
Creators: name: Nasyrov, Emil
name: Seppelfricke, Clara
name: Doycheva, Deshka
name: Gassel, Caroline J.
name: Merle, David A.
name: Voykov, Bogomil
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: To investigate the efficacy and safety of the Preserflo MicroShunt (PMS) in treating glaucoma secondary to different uveitic glaucoma (UG) types in a European population. This study evaluated consecutive eyes with UG that received the PMS. The primary outcome measure was 12-month surgical success (≥20% IOP reduction, target IOP of 6–21 mmHg). Complete success was considered without IOP-lowering medication or additional surgery other than needling. Qualified success A was considered regardless of medication use, and qualified success B regardless of medication and/or incisional bleb revision. The secondary outcome measures included revision and complication rates. Twenty-five eyes (viral group: 10 with Fuchs uveitis syndrome and six with herpetic uveitis; juvenile idiopathic arthritis (JIA) group: nine with JIA-related uveitis) were included. The 12-month complete success rate was significantly higher in the viral group than in the JIA group (69% vs 11%; p = 0.0059, log-rank test). The qualified success rates in the viral and JIA groups were 75% and 22% for category A (p = 0.029) and 94% and 56% for category B (p = 0.0237), respectively. Among the viral and JIA groups, 13% and 11% required medication, respectively. Incisional bleb revisions were conducted within 12 months in 25% and 78%, respectively (p = 0.0131, log-rank test). Complications were self-limiting, with no uveitic activity observed. The PMS is safe and effective for glaucoma secondary to viral anterior uveitis. Conversely, it is moderately effective in eyes with JIA-related UG, with a high probability of bleb fibrosis development.
Association of IL-23/IL-17 Pathway-Related Gene Polymorphisms with Idiopathic Scleritis in Chinese Han Population
Creators: name: Jing, Shixiang
name: Du, Liping
name: Su, Guannan
name: Cao, Qingfeng
name: Li, Lin
name: Li, Fangfang
name: Li, Na
name: Li, Fuzhen
name: Yang, Peizeng
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Cancer
subject: Mental Health

description: To examine the relationship between IL-23/IL-17 pathway gene polymorphisms and scleritis susceptibility in the Chinese Han population. We assessed IL-23/IL-17 pathway-related SNPs in 898 scleritis cases and 1,573 controls, employing stratified analysis to evaluate subtype-specific impacts and a discovery-validation cohort strategy to ensure genetic association reliability. IL-23 R/rs10789229 TC genotype and C allele, and the IL-21/rs2221903 TT genotype and T allele were more frequent in scleritis patients (Pc = 2.07 × 10−3-2.77 × 10−6, OR = 1.497–2.327, 95% CI = 1.216–3.219), particularly anterior scleritis (Pc = 3.88 × 10−3-2.95 × 10−6, OR = 1.507–2.378, 95% CI = 1.209–3.321). The IL-23 R/rs10789229 TT genotype and T allele, and the IL-21/rs2221903 TC genotype and C allele were found less common among scleritis patients overall (Pc = 2.07 × 10−3-4.18 × 10−6, OR = 0.436–0.668, 95% CI = 0.316–0.822) and in the anterior scleritis subgroups (Pc = 3.88 × 10−3-4.43 × 10−6, OR = 0.427–0.664, 95% CI = 0.306–0.827). The analysis of haplotypes showed a noteworthy surge of IL-23 R CCCG haplotype in both scleritis patients in general (Pc = 1.91 × 10−4) and those with anterior scleritis (Pc = 1.15 × 10−4). Conversely, the frequency of the IL-17A GAA haplotype was significantly lower among scleritis patients overall (Pc = 4.17 × 10−12) and in the anterior or posterior scleritis subgroups (Pc = 7.41 × 10−11; Pc = 0.021). Only the IL-23 R/rs10789229 variant demonstrated consistent replication in the validation cohort. The findings suggest that specific polymorphisms of IL-23/IL-17 pathway-related genes could confer risk to the development of scleritis in the Chinese Han population. Patients with varying subtypes of scleritis exhibit somewhat similar genetic profiles.
Increasing harms for bingo players: digitisation, commercialisation and regulatory inadequacy: a multi-site case study
Creators: name: Maltzahn, Kathleen
name: Whiteside, Mary
name: Lee, Helen
name: Cox, John
name: MacLean, Sarah
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 420699
subject: Public health not elsewhere classified

description: Background: Bingo is often understood as a low-harm form of gambling. This view has been challenged by a growing body of literature identifying gambling harm to bingo players in a range of countries. In this study, we aimed to identify which conditions enabled, facilitated, intensified or mitigated gambling harm for bingo players in three populations in Victoria in the context of corporate, technological and regulatory changes. Methods: Our qualitative study investigated experiences of bingo-related gambling harm in three populations in Victoria, Australia where bingo was popular and structural disadvantage common: Indigenous people in the east, Pacific people in the state’s north and older people on low or fixed incomes in the capital. Data was generated through interviews with 53 bingo players and 13 stakeholders as well as 12 participant observations of bingo sessions. Results: We found that while bingo is overwhelmingly positive for many players, a minority of bingo players and their families experience notable harm. Harm was generated through traditional paper-based bingo games, new technologies such as tablet-based bingo and by the widespread tactic of placing bingo sessions in close proximity to harmful electronic gambling machines. Overall, the risk of harm to bingo players appears to be escalating due to commercial, technological and regulatory changes. Conclusions: These changes can be better managed by regulators: reforms are needed to safeguard bingo’s distinct character as a lower-risk form of gambling at a time when it, and its players, are under threat. Significantly, we found that harm to bingo players is intensified by factors external to gambling such as racialised poverty and adverse life events. Strategies that recognise these factors and grapple with gambling harm to bingo players are needed.
Exploring Brazilian Consumer’s Profile and Perceived Innovations Toward Sustainable Cues on Chocolate Front-Of-Package Labeling
Creators: name: Kamphorst, Raquel Carvalho Machado
name: de Moraes, K.
name: Cemin, P.
name: Borges, B.K.M.
name: Anna, V. Sant’
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Plant Biology

description: A survey of 695 consumers was conducted to explore attitudes toward sustainable cues on chocolate labels. Results indicate that consumers in southernmost states preferred an organic certification seal. Those with higher education placed greater importance on cocoa origin and the presence of a producer image on the label, while higher-income consumers valued both cocoa origin and organic certification. High cocoa percentages and organic certification were frequently cited as innovations in chocolate by consumers who valued the producer’s image on the label. Meanwhile, consumers who prioritized cocoa origin most often identified vegan chocolates as innovative.
Heidegger and derrida: The conflict between hermeneutics and deconstruction in the context of rhetorical and communication theory
Creators: name: Desilet, Gregory
Publisher: name: Humanities Commons
Year: 2009
Subjects: subject: Communication
subject: Rhetoric
subject: Hermeneutics

description: Jacques Derrida's deconstructive analyses expose the sense in which hermeneutic strategies fall prey to the “metaphysical exigency”: an unargued and concealed choice significant to the exposition of a philosophical position. The roots of this choice come most fully to light in the context of Derrida's differentiation of his views from those of Martin Heidegger. These differences contain two issues crucial to an understanding of the relationship between language, rhetoric, and communication: intersubjectivity and disclosure of being. The confrontation between deconstruction and hermeneutics on these issues brings into question the possibilities for and the valuation of communication while offering the basis for a thoroughly rhetorical understanding of language‐using.
Is Spain's Hebrew Literature 'Spanish'?
Creators: name: Wacks, David
Publisher: name: Juan de la Cuesta Hispanic Monographs
Year: 2008
Subjects: subject: Spanish language
subject: Hebrew literature
subject: Literature, Medieval

description: The author surveys Spanish and Hebrew literary criticism to determine to what extent the Hebrew language production of medieval Iberian authors have been reflected or omitted from Spanish literary history and draws some conclusions as to the reasons why or why not.
Water Quality Improvement through Rainwater Tanks: A Review and Simulation Study
Creators: name: Imteaz, MA
name: Boulomytis, VTG
name: Yilmaz, Abdullah
name: Shanableh, A
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 401199
subject: Environmental engineering not elsewhere classified

description: First, this paper presents a thorough review of water quality data using a rainwater tank, categorizing the data as with and without sedimentation. Data are presented showing minimum, maximum, and mean values for the different parameters. The data measured from several sources reveal that water collected from the tank is much better than the water directly collected from the roof. In addition, to analyse the phenomena through a mathematical model, a hypothetical 5 kL rainwater tank with a 200 m2 roof was modelled with the MUSIC model. The simulations were compared with the measured water quality data from a rainwater tank in Melbourne. In general, we found that MUSIC’s simulations on the mean daily concentrations of total suspended solids (TSS) and total phosphorus (TP) are slight underestimations compared to the measured data from Melbourne. Further MUSIC simulations reveal that significant reductions in the daily maximum concentrations of TSS, TP, and total nitrogen (TN) are expected through a rainwater tank.
Effects of Innovative Cooking Techniques on the Physico-Chemical, Color, Structural and Sensory Properties of the Rainbow Trout (O. mykiss)
Creators: name: Kocatepe, Demet
name: Turan, Hülya
name: Gulgun, Unal Sengor F.
name: Corapcı, Bengunur
name: Altan, Can Okan
name: Kostekli, Bayram
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Neuroscience
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: In this study, the effects of different cooking techniques on some physicochemical, color, texture and sensory properties of rainbow trout farmed in net cage systems were investigated. The greatest water loss was found in the deep-fried group and the least water loss in sous vide group. The pH of the groups increased with cooking, but lowest pH was fish cooked sous vide. The highest L* value was determined from the group cooked under pressure of 70KPa (p < 0.05), while the lowest L* value was observed in the deep-fried group (p < 0.05). The maximum hardness (N) was found in the group cooked under pressure of 10KPa (p < 0.05). Pressure cooking techniques in automatic cookers for cooking trout cubes can be said to be one of the most suitable innovative cooking methods when color, textural characteristics and sensory juiciness values are taken into account in meat texture. Fish meat is a valuable food. Suitable for both home and restaurant consumption, delicious, aromatic, healthy, perishable, and suitable for various cooking methods. In addition, it is a product with high sales value. Large rainbow trout (over kilograms) grown in the Black Sea has a high yield of meat and is sold for $13–14 per kg on both the domestic and foreign markets. Although all frying methods are applicable to this fish. This study examined whether the products prepared in new generation auto cooker and sous vide cookers are preferred by the consumers. The main criteria for buying raw fish are firmness to the touch, structure of the eye, redness of the gills, etc. such factors. What is desired in the end product that comes from the the sea to plate is a fish meat that is visually appealing in color and texture and leaves a unique taste and aroma on the palate when consumed. From this point of view, it was found that the color, uniformity and sensory characteristics of large rainbow trout cooked with automatic cookers used in both domestic and industrial kitchens are better.
K_Chen_supplemental_material – Supplemental material for How deliberative designs empower citizens’ voices: A case study on Ghana’s deliberative poll on agriculture and the environment
Creators: name: Kaiping Chen
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications
subject: Science Policy

description: Supplemental material, K_Chen_supplemental_material for How deliberative designs empower citizens’ voices: A case study on Ghana’s deliberative poll on agriculture and the environment by Kaiping Chen in Public Understanding of Science
Carstensen_Supplemental_Material_rev – Supplemental material for Age Advantages in Emotional Experience Persist Even Under Threat From the COVID-19 Pandemic
Creators: name: Carstensen, Laura L.
name: Shavit, Yochai Z.
name: Barnes, Jessica T.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: Neuroscience

description: Supplemental material, Carstensen_Supplemental_Material_rev for Age Advantages in Emotional Experience Persist Even Under Threat From the COVID-19 Pandemic by Laura L. Carstensen, Yochai Z. Shavit and Jessica T. Barnes in Psychological Science
Supplemental Material, Supp_1_All_87_cases - Anomalous Origin of the Circumflex or Left Anterior Descending Artery From the Pulmonary Artery
Creators: name: Guenther, Timothy M.
name: Sherazee, Elan A.
name: Gustafson, Joshua D.
name: Wozniak, Curtis J.
name: Brothers, Julie
name: Raff, Gary
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: Cardiology
subject: 111403 Paediatrics
subject: FOS: Clinical medicine
subject: 110323 Surgery

description: Supplemental Material, Supp_1_All_87_cases for Anomalous Origin of the Circumflex or Left Anterior Descending Artery From the Pulmonary Artery by Timothy M. Guenther, Elan A. Sherazee, Joshua D. Gustafson, Curtis J. Wozniak, Julie Brothers and Gary Raff in World Journal for Pediatric and Congenital Heart Surgery
SupplementaryFiles – Supplemental material for Comprehensive proteomic atlas of skin biomatrix scaffolds reveals a supportive microenvironment for epidermal development
Creators: name: Leng, Ling
name: Ma, Jie
name: Sun, Xuer
name: Guo, Baolin
name: Li, Fanlu
name: Zhang, Wei
name: Chang, Mingyang
name: Diao, Jinmei
name: Wang, Yi
name: Wang, Wenjuan
name: Wang, Shuyong
name: Zhu, Yunping
name: He, Fuchu
name: Reid, Lola M
name: Wang, Yunfang
Publisher: name: SAGE Journals
Year: 2020
Subjects: Dentistry not elsewhere classified
Biological Sciences not elsewhere classified

description: Supplemental material, SupplementaryFiles for Comprehensive proteomic atlas of skin biomatrix scaffolds reveals a supportive microenvironment for epidermal development by Ling Leng, Jie Ma, Xuer Sun, Baolin Guo, Fanlu Li, Wei Zhang, Mingyang Chang, Jinmei Diao, Yi Wang, Wenjuan Wang, Shuyong Wang, Yunping Zhu, Fuchu He, Lola M Reid and Yunfang Wang in Journal of Tissue Engineering
Workplace violence against emergency health care workers: What Strategies do Workers use?
Creators: name: Spelten, Evelien
name: Van-Vuuren, Julia
name: O’Meara, P
name: Thomas, Brodie
name: Grenier, M
name: Ferron, R
name: Helmer, J
name: Agarwal, G
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 420699
subject: Public health not elsewhere classified

description: Background: Workplace violence by patients and bystanders against health care workers, is a major problem, for workers, organizations, patients, and society. It is estimated to affect up to 95% of health care workers. Emergency health care workers experience very high levels of workplace violence, with one study finding that paramedics had nearly triple the odds of experiencing physical and verbal violence. Many interventions have been developed, ranging from zero-tolerance approaches to engaging with the violent perpetrator. Unfortunately, as a recent Cochrane review showed, there is no evidence that any of these interventions work in reducing or minimizing violence. To design better interventions to prevent and minimize workplace violence, more information is needed on those strategies emergency health care workers currently use to prevent or minimize violence. The objective of the study was to identify and discuss strategies used by prehospital emergency health care workers, in response to violence and aggression from patients and bystanders. Mapping the strategies used and their perceived usefulness will inform the development of tailored interventions to reduce the risk of serious harm to health care workers. In this study the following research questions were addressed: (1) What strategies do prehospital emergency health care workers utilize against workplace violence from patients or bystanders? (2) What is their experience with these strategies? Methods: Five focus groups with paramedics and dispatchers were held at different urban and rural locations in Canada. The focus group responses were transcribed verbatim and analyzed using thematic analysis. Results: It became apparent that emergency healthcare workers use a variety of strategies when dealing with violent patients or bystanders. Most strategies, other than generic de-escalation techniques, reflect a reliance on the systems the workers work with and within. Conclusion: The study results support the move away from focusing on the individual worker, who is the victim, to a systems-based approach to help reduce and minimize violence against health care workers. For this to be effective, system-based strategies need to be implemented and supported in healthcare organizations and legitimized through professional bodies, unions, public policies, and regulations.
Assessment of Phenolic Compound Bioaccessibility in Yerba Mate-Supplemented Bread via in vitro Gastrointestinal Simulation
Creators: name: Santetti, Gabriela Soster
name: Dacoreggio, Marina Volpato
name: Inácio, Heloísa Patricio
name: da Silva Monteiro Wanderley, Bruna Rafaela
name: da Silva Haas, Isabel Cristina
name: Biduski, Barbara
name: Hoff, Rodrigo Barcellos
name: Bertolin, Telma Elita
name: Freire, Carlise Beddin Fritzen
name: Gutkoski, Luiz Carlos
name: de Mello Castanho Amboni, Renata Dias
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified

description: This research investigated how incorporating yerba mate (YM) affects whole grain bread’s phenolic profile and in vitro antioxidant activity following simulated gastrointestinal conditions. Three samples were prepared: BWWF (control), B1, and B2 (2.5 and 4.5% YM, respectively). Some phenolic compounds in breads, such as chlorogenic, benzoic, syringic, p-coumaric, and syringaldehyde acid, showed bioaccessible potential since they appeared during the three phases of gastrointestinal digestion. In the gastric phase the compounds present, ferulic acid (bread WWF) was the major compound with 6960 µg/g, for bread with 2.5% YM and bread with 4.5% YM was rutin and chlorogenic acid with 14,945 µg/g and 7881 µg/g, respectively. In the intestinal phase, there was a significant reduction in the levels of phenolic compounds. Bioaccessibility was influenced by the addition of YM, indicating that including this plant in food could add value to this regional product.
A phase 1b open-label study of sodium selenate as a disease-modifying treatment for possible behavioral variant frontotemporal dementia
Creators: name: Vivash, Lucy
name: Malpas, Charles B
name: Meletis, Christian
name: Gollant, Meghan
name: Eratne, Dhamidhu
name: Li, Qiao-Xin
name: McDonald, Stuart
name: O'Brien, William T
name: Brodtmann, Amy
name: Darby, David
name: Kyndt, Christopher
name: Walterfang, Mark
name: Hovens, Christopher M
name: Velakoulis, Dennis
name: O'Brien, Terence J
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 320299
subject: Clinical sciences not elsewhere classified
classificationCode: 320999
subject: Neurosciences not elsewhere classified

description: Introduction: Sodium selenate increases tau dephosphorylation through protein phosphatase 2 activation. Here we report an open-label Phase 1b study of sodium selenate as a disease-modifying treatment for behavioral variant frontotemporal dementia (bvFTD). Methods: Twelve participants with bvFTD received sodium selenate (15 mg, three times a day) for 52 weeks. Safety assessments were carried out throughout the trial. Primary outcomes were frequency of adverse events (AEs), serious adverse events (SAEs), and discontinuations. Secondary outcomes of potential efficacy included cognitive and behavioral assessments, magnetic resonance imaging (MRI) whole brain volume, and cerebrospinal fluid (CSF) and blood total tau (t-tau), phosphorylated tau (p-tau), and neurofilament light (NfL) levels, which were measured at baseline and at week 52. Results: Sodium selenate was safe and well tolerated. All participants completed the study, and the majority (64.7%) of reported AEs were mild. One SAE occurred, which was not treatment related. Small declines in MRI and cognitive and behavioral measures were observed over the treatment period. There was no evidence for change in CSF protein levels (t-tau, p-tau, or NfL). Further analysis showed two distinct groups when measuring disease progression markers over the course of the study-one (n = 4) with substantial brain atrophy (2.5% to 6.5% reduction) and cognitive and behavioral decline over the 12-month treatment period, and the second group (n = 7) with no detectable change in cognitive and behavioral measures and less brain atrophy (0.3% to 1.7% reduction). Conclusion: Sodium selenate is safe and well tolerated in patients with bvFTD. Randomized-controlled trials are warranted to investigate potential efficacy.
Physics and language—science and rhetoric: Reviewing the parallel evolution of theory on motion and meaning in the aftermath of the Sokal Hoax
Creators: name: Desilet, Gregory
Publisher: name: Humanities Commons
Year: 2009
Subjects: subject: Communication
subject: Rhetoric
subject: Science--Philosophy

description: Alan Sokal's concern about a decline in intellectual standards includes an indictment of what he calls current “subjectivist” trends accompanying a general erosion of “objectivity “ stemming from postmodern views such as deconstruction. This erosion is identified most importantly in postmodern claims about the instability of rigorous distinctions between opposites. This study argues that the deconstructive practice of disturbing the status quo between opposites extends as far back as Newton and constitutes one of the central themes of physics since the Enlightenment. Parallel developments in physics and language studies are summarized from Aristotle to Einstein and quantum theory‐all in support of the contention that to question postmodern language theory exemplified in deconstruction necessitates questioning also the parallel developments in physics from Newton to the present time. Both physics and language theory make rigorous distinctions between opposites a thing of the past. This circumstance necessitates, contrary to what Sokal argues and consistent with current themes in the rhetoric of science, a construction of reality in language and experience which is nevertheless not essentially subjectivist, objectivist, nor relativist.
Supplementary_Material_Post_Training_Questions – Supplemental material for A Music-Based Digital Therapeutic: Proof-of-Concept Automation of a Progressive and Individualized Rhythm-Based Walking Training Program After Stroke
Creators: name: Hutchinson, Karen
name: Sloutsky, Regina
name: Collimore, Ashley
name: Adams, Benjamin
name: Harris, Brian
name: Ellis, Terry D.
name: Awad, Louis N.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: Neuroscience

description: Supplemental material, Supplementary_Material_Post_Training_Questions for A Music-Based Digital Therapeutic: Proof-of-Concept Automation of a Progressive and Individualized Rhythm-Based Walking Training Program After Stroke by Karen Hutchinson, Regina Sloutsky, Ashley Collimore, Benjamin Adams, Brian Harris, Terry D. Ellis and Louis N. Awad in Neurorehabilitation and Neural Repair
Assessing the impact of gestational age of donors on the efficacy of amniotic epithelial cell-derived extracellular vesicles in experimental bronchopulmonary dysplasia
Creators: name: Zhu, Dandan
name: Krause, Mirja
name: Yawno, Tamara
name: Kusuma, Gina D
name: Schwab, Renate
name: Barabadi, Mehri
name: Maleken, Amina S
name: Chan, Siow T
name: Rod, Hunt
name: Greening, David
name: Wallace, Euan M
name: Lim, Rebecca
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 320299
subject: Clinical sciences not elsewhere classified
classificationCode: 321599
subject: Reproductive medicine not elsewhere classified

description: BACKGROUND AND RATIONALE: Extracellular vesicles (EVs) are a potential cell-free regenerative medicine. Human amniotic epithelial cells (hAECs) are a viable source of cell therapy for diseases like bronchopulmonary dysplasia (BPD). However, little is known about the impact of gestational age of the donor on the quality of hAEC-derived EVs. AIMS: To determine the impact of gestational age on hAEC-derived EVs in experimental BPD. RESULTS: Term hAEC-derived EVs displayed a significantly higher density of surface epitopes (CD142 and CD133) and induced greater macrophage phagocytosis compared to preterm hAEC-EVs. However, T cell proliferation was more significantly suppressed by preterm hAEC-EVs. Using a model of experimental BPD, we observed that term but not preterm hAEC-EVs improved tissue-to-airspace ratio and septal crest density. While both term and preterm hAEC-EVs reduced the levels of inflammatory cytokines on postnatal day 7, the improvement in lung injury was associated with increased type II alveolar cells which was only observed in term hAEC-EV treatment group. Furthermore, only neonatal term hAEC-EVs reduced airway hyper-responsiveness, mitigated pulmonary hypertension and protected against right ventricular hypertrophy at 6 weeks of age. CONCLUSION: Term hAEC-EVs, but not preterm hAEC-EVs, have therapeutic efficacy in a mouse model of BPD-like lung injury. Therefore, the impact of donor criteria should be considered when applying perinatal cells-derived EV therapy for clinical use.
Additional file 1 of Characterization of the intestinal fungal microbiome in patients with hepatocellular carcinoma
Creators: name: Zhang, Lilong
name: Chen, Chen
name: Chai, Dongqi
name: Li, Chunlei
name: Qiu, Zhendong
name: Kuang, Tianrui
name: Liu, Li
name: Deng, Wenhong
name: Wang, Weixing
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified

description: Additional file 1. Additional detailed experimental methodology.
How To See Palestine: An ABC of Occupation
Creators: name: Mirzoeff, Nick
Publisher: name: unknown
Year: 2016
Subjects: subject: History
subject: Mass media--Study and teaching
subject: Culture--Study and teaching
subject: Middle East

description: This is a print version of a Scalar-based website at http://scalar.usc.edu/nehvectors/how-to-see-palestine/index.
It is Creative Commons free/libre/open. Use as you will.
description: This is a print version of a Scalar-based website at http://scalar.usc.edu/nehvectors/how-to-see-palestine/index. It is Creative Commons free/libre/open. Use as you will.