cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
And She Called His Name Seth . . . (Gen 4:25): The Birth of Critical Knowledge and the Unread End of Eve's Story
Creators: name: Kahl, Brigitte W.
Publisher: name: Columbia University
Year: 1999
Subjects: subject: Religion
subject: Spirituality
subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: Theology
subject: Life of Adam and Eve
subject: Women
subject: Idols and images--Biblical teaching
subject: Patriarchy

description: Eve. For how many centuries now has she been frozen under the tree of knowledge with the deadly, sinful apple in her hand? We have seen the paintings, we know the quotations, some of them, like Timothy 2:8-15, in the New Testament, and many more in the church fathers and other texts and traditions. Throughout the ages the patriarchal Christian dis-course has bound her to the nakedness of her ageless body and to never-ending debates about femininity, sexuality, and sin. Turned into a pillar of salt she had to stand there under the tree, testifying that womanhood equals guilt, incapacity to think, fallibility—and the need of infallible male guidance. Since ever and forever. In the meantime, we have started in manifold ways and voices to deconstruct this image of Eve as a male idol. The pressing question for a biblical scholar, however, is: To what extent is the biblical text itself involved in this kind of patriarchal idolatry—and/or resistant to it? What I want to share with you right here is a tiny piece of "resistant text" and a kind of discovery: the suppressed end of Eve's story. How it continued with her after—unnoticed by the dogmatic debates—she finally got rid of the tree and started to grow: to grow adult, to grow old, to grow wise. Not that I have dug a new extracanonical document out of the sand—digging in the text can be at least as much exciting. And it has been there in the text all the time: two little verses at the end of Genesis 4, which rarely have been really read. Under the censorship of the dominant reading interests they were just seen as a more or less disconnected appendix, perhaps related to chapter 5. In fact, these two verses, as I read them, contain the very climax and reversal of the whole story of Eve.
A Poststructuralist Liberation Theology?: Queer Theory and Apophaticism
Creators: name: Daniels, Brandy
Publisher: name: Columbia University
Year: 2013
Subjects: subject: Religion
subject: Spirituality
subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: Theology

description: From an early emphasis on "the preferential option for the poor" and roots in the plight of the economically downtrodden in South America, to a call for the recognition of the "blackness of God," to gendered justice and language for God, liberation theology has foregrounded interpreting Christianity from the lens of the marginalized and stressed a telos of justice and freedom from systemic oppression. While not precluding these laudable values, poststructural theory has raised questions of the viability and efficacy of liberationist aims and methodologies. In this paper, I will examine some key critiques proffered by poststructuralism and gesture toward a potential constructive response that attends to these concerns while remaining firmly within a liberationist paradigm.
Pollination of Rubus arcticus L. in Alberta: microclimate effects on pollinator availability and the role of pollen limitation on fruit set
Creators: name: Burns, Cole
Publisher: name: Graduate Studies
Year: 2018
Subjects: subject: Pollen Limitation
subject: Microclimate
subject: Pollen Quantity
subject: Pollen Quality
subject: Fruit set
subject: Pollen Supplementation
subject: Pollinator Diversity
subject: Foraging Duration
subject: Visitation
subject: Rubus arcticus
subject: Arctic Raspberry
subject: Hemispherical Photography
subject: Time-lapse Photography
subject: Pollinator Surveys
subject: Biology
subject: Botany
subject: Ecology
subject: FOS: Biological sciences
subject: Plant Physiology

description: Rubus arcticus Linnaeus is a widespread plant species that likely experiences changes in pollinator visitation and fruit production with microclimate. A pollen supplementation experiment with open controls, pure-selfed and outcross supplemented treatments was used to determine if R. arcticus fruit production is limited in the quantity of pollen deposited. This experiment was then complemented by a pollen tube analysis to determine the importance of pollen quality. To determine the effects of microclimate on R. arcticus pollinator availability and foraging behavior, pollinator surveys were conducted using time-lapse photography which was accompanied by micrometeorological monitoring with measurements from humidity/temperature loggers, an anemometer for wind speed, and hemispherical photography for solar irradiance. The results provide evidence that fruit production in R. arcticus can be extremely low in regions that are at the southern parts of its range, but this low fruit production does not necessarily reflect pollen limitation. The dominant pollinators of the study population were syrphid flies, which exhibited visitation frequencies that were influenced by temperature and humidity
A Tribute to John A. McGuckin
Creators: name: Lasser, Justin M.
Publisher: name: Columbia University
Year: 2012
Subjects: subject: Religion
subject: Spirituality
subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: Theology

description: Dr. McGuckin is one of those rare figures in the history of Christian theology that can distill the historical contours of the ancient world and its ancient faith while also gleaning the more potent aspects that continue to influence the lives of both countless Christians around the world and those who know him most intimately. He has the exceptional talent of both preserving and communicating an ancient faith, rather than an ancient mind. This ability to communicate the beauties and mysteries of the ancient faith of Orthodox Christianity for a new generation, without requiring the adoption of an ancient mind, is what makes him so accessible to both students and friends alike. For those who frequent the halls of Union Theological Seminary, it is not uncommon to find students hurrying behind Dr. McGuckin trying to catch up with him, just to hear another word of witty wisdom. Indeed, I too, as a student of Dr. Mc- Guckin, found myself on numerous occasions trying to have yet another word with him as he left the lecture hall. While I’m sure he would have preferred to go home for lunch, he always took the time to listen to his students and entertain their ideas and further inquiries. This inability to ‘just leave’ the lecture-hall after class was, of course, Dr. McGuckin’s own fault, for it was his uncanny ability to deliver wisdom with great wit that drew students like myself to ask him further questions.
Consequence Delimiting: A Grounded Theory of Healthcare Leader Decision Making in the Context of Adverse Events
Creators: name: McRae, Leonard Glenn
Publisher: name: Graduate Studies
Year: 2018
Subjects: subject: adverse events
subject: healthcare leader
subject: accountable leader
subject: Classic Grounded Theory
subject: consequence delimiting
subject: determining accountability
subject: Health Care Management
subject: Nursing
subject: FOS: Health sciences

description: Adverse events (AEs) remain a central focus of North American healthcare leaders (HLs) since the release of the Institute of Medicine’s (IOM) report: “To Err is Human” in 1999 (Institute of Medicine, 1999). The IOM reported that as many as 98,000 people died from preventable deaths every year in the United States as a result of errors in the delivery of healthcare. Studies in other healthcare systems report comparable rates of harm (Baker et al., 2004; Thomas et al., 2000; Vincent, Neale, & Woloshynowych, 2001). The high incidence of AEs coupled with healthcare leaders’ fiduciary and regulatory responsibilities to manage these events result in its central import for healthcare leaders. The aim of this study was to discover a general substantive theory on how HLs approach accountability in the context of adverse events (AEs). The research findings were that the main concern of HLs was determining how to respond to each AE. Consequence Delimiting emerged as the core category of this classic grounded theory (CGT). The theory was conceptualized as a stage theory where multiple phases proceed sequentially and each produces a product that is built upon by subsequent stages to ultimately produce an outcome. Consequence Delimiting begins at the time that the HL accountable for managing the AE; the accountable leader (AL) becomes aware of the AE and proceeds through the interrelated categories of apprehending, story constructing, expectation navigating and truth promoting to an event disposition. The emergent theory takes particular cognizance of the role that context and discretion play in determining the disposition of an AE. It highlights the influence of organizational and leadership culture, constraints and the role of pathways in influencing the disposition. Consequence Delimiting has implications for regulators and healthcare leaders interested in better understanding and improving patient safety in their organizations.
Extract to unravel: Left branch extraction in Romanian/Serbian code-switching
Creators: name: Petroj, Vanessa
Publisher: name: Zenodo
Year: 2019
Subjects: left branch extraction
code-switching
Romanian
Serbian

description: Bošković (2008; 2012) argues that languages with and without articles differ con-

siderably with respect to the structure of the nominal domain (among other dif-

ferences), leading to a distinction between DP (languages with articles) and NP

(article-less) languages. Namely, DP languages are proposed to have a functional

layer (DP) above the NP where articles are presumed to be positioned, while lack-

ing definite articles indicates the absence of this functional layer in a language,

allowing for bare NPs. This structural difference has semantic and syntactic conse-

quences, one of which is the (im)possibility of left branch extraction (LBE) of ad-

jectives and adjective-like elements out of the nominal domain. Specifically, while

LBE is allowed in NP languages, is it disallowed in DP languages (Bošković 2008;

2012). While (dis)allowing LBE is fairly straightforward in languages in isolation,

here, I extend this test to mixed DP/NP structures resulting from Romanian/Serbian

code-switching (CS). Following the DP/NP language distinction, I consider Roma-

nian to be a DP language, disallowing LBE, and Serbian an NP language, allowing

LBE. Consequentially, I apply the LBE of adjectives from internal and external ar-

guments of the verb, with switches at various points in the derivation. I show that

LBE is reliable in determining the points where CS occurs, whether we are dealing

with an NP or a DP projection, but also in showing that mixing two languages may

not necessarily result in a uniform system. In other words, through LBE, the struc-

tural flexibility resulting from different points of CS indicates that CS, like LBE, is

highly contextual and sensitive to phases and phasal domains.
Beyond Consolation: The Significance of Failure for Faith
Creators: name: Wise, Heather
Publisher: name: Columbia University
Year: 2014
Subjects: subject: Religion
subject: Spirituality
subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: Theology

description: Christopher Morse, the Dietrich Bonhoeffer Professor Emeritus of Theology and Ethics at Union Theological Seminary, teaches how to "test the spirits," not only of the tradition, but also of we ourselves, as theology witnesses our transformation into who God made us to be. The following presentation, which I gave on April 25, 2013 at Columbia University’s Teacher’s College for non-theologians engaged in an interdisciplinary seminar series, shows how Morse’s work influences theology and theology’s engagement with other disciplines, so we can best find what it means to be human, or, as Bonhoeffer emphasized, following the apostle Paul, that "God is for us." In gratitude for all Morse has taught me about doing dogmatics as a "theology of freedom" —each one of us invited to test the evidence presented because God, as "the One who loves in freedom," can be trusted to con- firm or convict what we conclude—I write as a witness to what God is doing and the difference it makes in our lives and communities as my mentor has so faithfully done for decades.
Beholding Beauty In Nicetas Stethatos’ Contemplation of Paradise
Creators: name: Pereira, Matthew J.
Publisher: name: Columbia University
Year: 2012
Subjects: subject: Religion
subject: Spirituality
subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: Theology

description: In Standing in God’s Holy Fire, a jewel of an introduction to the rich heritage of Byzantine spirituality, John Anthony McGuckin rightly affirms the centrality of beauty within the eastern Christian tradition. There is no other concept, McGuckin asserts, that "so summates the ethos or guiding cultural spirit of eastern Christianity as much as that perennial search for beauty which inspired and organised the Byzantine mystical quest." The search for beauty, according to McGuckin, provides the vital organizing principle within the Byzantine tradition. The eastern Christian tradition in all its complexity and continuity, beginning with the likes of Origen of Alexandria, followed by the Cappadocian Fathers ( Basil of Caesarea, Gregory of Nazianzus, and Gregory of Nyssa ), and up through Maximus the Confessor and Symeon the New Theologian, boasts of numerous mystical theologians who have composed writings filled with vivid descriptions of the soul’s ascent toward the beautiful. Beyond the above-mentioned bright luminaries and other notables of the eastern mystical tradition loom numerous lesser-known Byzantine theologians, who in consonance with their more highly touted counterparts, have consistently reflected upon the ultimate reality and importance of divine beauty.
$W_H/Z_H$ production associated with a T-odd (anti)quark at the LHC in NLO QCD
Creators: name: Ren-You, Zhang
name: Han, Yan
name: Wen-Gan, Ma
name: Shao-Ming, Wang
name: Lei, Guo
name: Liang, Han
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: In the framework of the littlest Higgs model with T parity, we study the $W_H/Z_H$ production in association with a T-odd (anti)quark of the first two generations at the CERN Large Hadron Collider up to the QCD next-to-leading order. The kinematic distributions of final decay products and the theoretical dependence of the cross section on the factorization/renormalization scale are discussed. We apply three schemes in considering the QCD NLO contributions and find that the QCD NLO corrections by adopting the (II) and (III) subtraction schemes can keep the convergence of the perturbative QCD description and reduce the scale uncertainty of the leading order cross section. By using these two subtraction schemes, the QCD NLO corrections to the $W_H(Z_H) q_-$ production process enhance the leading order cross section with a K-factor in the range of $1.00 \sim 1.43$.
description: 31 pages, 12 figures, accepted by Phys. Rev. D
Catalytic Upgrading Process of Ligno-cellulose Derived Heavy Crude Oil
Creators: name: Trujillo Vaccari, Marianna Isabel
Publisher: name: Graduate Studies
Year: 2018
Subjects: subject: Catalysis
subject: Upgrading
subject: Lignocellulose
subject: Biomass
subject: Heavy Crude Oil
subject: Hydrotreating
subject: Steam Cracking
subject: Bio-oil
subject: Bio-crude
subject: Hydrogen
subject: Catalytic
subject: Process
subject: Lignocellulosic Biomass
subject: Engineering
subject: Engineering--Chemical

description: The high oxygen content of lignocellulose-derived bio-crudes results in thermal instability, corrosiveness, and low energy density in comparison to petroleum fuels. A pioneer Catalytic Upgrading Process is investigated in this thesis through a first-of-a-kind combination of two hydrogen addition processes, namely a first hydrogenation step and a second steam-cracking step producing lighter fractions and hydrogen. The preliminary effect of operating conditions was evaluated for each process using a fixed-bed reactor configuration. First, a Hydrotreating process at 320oC, 0.20h-1, and 1400-psig that achieved 59% hydro-deoxygenation, and >98% total acid number reduction was implemented. Complementarily, Catalytic Steam Cracking as secondary process completed desired conversion to petroleum equivalents of 5.6% Naphtha (IBP-190oC), 12.8% Jet-fuel (190-260oC) and 25.6% Diesel (260-343oC) range hydrocarbons, supplying hydrogen by the catalytic splitting of water, thus omitting the requirements for costly hydrogen sources or high-pressure equipment as in Hydrocracking processes. One novelty relies on the recycle of unconsumed hydrogen, at least partially sourcing the hydrotreater’s hydrogen consumption.
title: Issuance of Permits for RESTORE Act research on Gulf of Mexico Bryde's Whale
titleType: AlternativeTitle
title: National Marine Fisheries Service Endangered Species Act Section 7 Biological And Conference Opinion Biological and Conference Opinion on the Issuance of Permit Nos. 14550, 14856, 16239, 17312, and 18636, for Research on Gulf of Mexico Bryde’s whales, and Activities to be Conducted under the Resources and Ecosystems Sustainability, Tourist Opportunities, and Revived Economies (RESTORE) Act Grant
Creators: name: United States. National Marine Fisheries Service. Office of Protected Resources
Publisher: name: United States. National Marine Fisheries Service. Office of Protected Resources
Year: 2018

description: OPR-2017-00033
Horizontal and temporal variability of transport processes in lakes
Creators: name: Forrest, Alexander LeBaron
Publisher: name: University of British Columbia
Year: 2011

description: This work examines the three dimensional nature of three important physical transport processes in lakes: (1) convection generated from a negative surface buoyancy flux; (2) transport resulting from rotational adjustment; and, (3) underflow fate during episodic wind stirring. Vertical and horizontal temperature gradients were characterized using a combination of traditional (moorings and vertical profilers) and novel techniques (an Autonomous Underwater Vehicle) at two sites; Pavilion Lake, British Columbia, Canada and Lake Thingvallavatn, Iceland. The former site is a relatively small (5 km²), temperate lake, with comparatively low snow cover that allows solar radiation to be the dominant energy flux to the system during late winter months. Analysis of water temperature distribution in surface waters during summer and winter enabled convective patterns resulting from a negative surface buoyancy flux to be inferred. In addition to previously studied physical transport phenomena, this work has revealed the existence of a cyclonic eddy under winter ice cover in Pavilion Lake, consistent with the internal Rossby radius of deformation, extending down to ~ 14 m below the ice surface and rotating with an azimuthal speed of ~ 3 cm s⁻¹ (as predicted by equations of cyclogeostrophic flow). Horizontal temperature transects beneath the eddy revealed temperature fluctuations associated with 1 – 2 m vertical displacements in the region 5 m directly below the eddy and are thought to be an undocumented source of mass transport. The latter field site was an embayment of a larger (88 km²) subarctic lake with a groundwater inflow that propagates through the embayment as a negatively buoyant underflow. Surface wind shear events entrain the underflow into the overlying lake water. This entrainment alters the characteristics and the ultimate fate of the underflow in the lake. Calculated entrainment of the underflow and entrainment calculated from the bulk Richardson number are in close agreement. Measurements made during these studies not only elucidated details of the three dimensional nature of known transport mechanisms but also revealed previously undiscovered modes of mass transport associated with wintertime lake hydrodynamics.
The responsibility to protect in Congo: the failure of grassroots prevention
Creators: name: Autesserre, Severine
Publisher: name: Columbia University
Year: 2015
Subjects: Peace-building
Peacekeeping forces
War--Causes

description: Prevention was the most important dimension of the Responsibility to Protect’s foundational documents and subsequent advocacy efforts. However, the actual implementation of protection on the ground has focused on reacting to crises. This article develops a case study of war resumption in Congo in 2008 to understand why and how this happened. International peacebuilders took preventive action in Congo, but not as part of the protection efforts. Peacebuilders focused on preventing renewed national and regional wars, and they ignored the local conflicts that fueled these broader tensions. The reason for this lies in a dominant culture of international peacebuilding. This culture shaped international efforts in such a way that the three essential conditions for effective prevention – political will, early warning, and the preventive toolbox – were present for the prevention of renewed national and regional fighting but absent for the prevention of local violence. The resulting strategy allowed a crisis localized in the province of North Kivu to escalate into a full-scale war. The same type of effect appears generalizable across several recent interventions.
CCR2 receptor ligands inhibit Cav3.2 T-type calcium channels
Creators: name: You, Haitao
name: Altier, Christophe
name: Zamponi, Gerald W.
Publisher: name: The American Society for Pharmacology and Experimental Therapeutics
Year: 2010

description: Monocyte chemoattractant protein-1 (MCP-1) is a cytokine known to be involved in the recruitment of monocytes to sites of injury. MCP-1 activates the chemokine (C-C motif) receptor 2 (CCR2), a seven-transmembrane helix G protein-coupled receptor that has been implicated in inflammatory pain responses. Here we show that MCP-1 mediates activation of the CCR2 receptor and inhibits coexpressed N-type calcium channels in tsA-201 cells via a voltage-dependent pathway. Moreover, MCP-1 inhibits Ca(v)3.2 calcium channels, but not other members of the Cav3 calcium channel family, with nanomolar affinity. Unlike in N-type channels, this modulation does not require CCR2 receptor activation and seems to involve a direct action of the ligand on the channel. Whole-cell T-type calcium currents in acutely dissociated dorsal root ganglia neurons are effectively inhibited by MCP-1, consistent with the notion that these cells express Ca(v)3.2. The effects of MCP-1 were eliminated by heat denaturation. Furthermore, they were sensitive to the application of the divalent metal ion chelator diethylenetriaminepentaacetic acid, suggesting the possibility that metal ions may act as a cofactor. Finally, small organic CCR2 receptor antagonists inhibit Ca(v)3.2 and other members of the T-type channel family with micromolar affinity. Our findings provide novel avenues for the design of small organic inhibitors of T-type calcium channels for the treatment of pain and other T-type channel linked disorders.
Role of voltage-gated calcium channels in epilepsy
Creators: name: Lory, Philippe
name: Perez-Reyes, Edward
name: Zamponi, Gerald W.
Publisher: name: Springer-Verlag
Year: 2010

description: It is well established that idiopathic generalized epilepsies (IGEs) show a polygenic origin and may arise from dysfunction of various types of voltage- and ligand-gated ion channels. There is an increasing body of literature implicating both high- and low-voltage-activated (HVA and LVA) calcium channels and their ancillary subunits in IGEs. Cav2.1 (P/Q-type) calcium channels control synaptic transmission at presynaptic nerve terminals, and mutations in the gene encoding the Cav2.1 alpha1 subunit (CACNA1A) have been linked to absence seizures in both humans and rodents. Similarly, mutations and loss of function mutations in ancillary HVA calcium channel subunits known to co-assemble with Cav2.1 result in IGE phenotypes in mice. It is important to note that in all these mouse models with mutations in HVA subunits, there is a compensatory increase in thalamic LVA currents which likely leads to the seizure phenotype. In fact, gain-of-function mutations have been identified in Cav3.2 (an LVA or T-type calcium channel encoded by the CACNA1H gene) in patients with congenital forms of IGEs, consistent with increased excitability of neurons as a result of enhanced T-type channel function. In this paper, we provide a broad overview of the roles of voltage-gated calcium channels, their mutations, and how they might contribute to the river that terminates in epilepsy.
Cosmological perturbations in Massive Gravity and the Higuchi bound
Creators: name: Fasiello, Matteo
name: Tolley, Andrew J.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In de Sitter spacetime there exists an absolute minimum for the mass of a spin-2 field set by the Higuchi bound m^2 \geq 2H^2. We generalize this bound to arbitrary spatially flat FRW geometries in the context of the recently proposed ghost-free models of Massive Gravity with an FRW reference metric, by performing a Hamiltonian analysis for cosmological perturbations. We find that the bound generically indicates that spatially flat FRW solutions in FRW massive gravity, which exhibit a Vainshtein mechanism in the background as required by consistency with observations, imply that the helicity zero mode is a ghost. In contradistinction to previous works, the tension between the Higuchi bound and the Vainshtein mechanism is equally strong regardless of the equation of state for matter.
description: 24 pages, typos and conventions corrected
A North African Quartet
Creators: name: Phelps, Edmund S.
name: Ammous, Saifedean H.
Publisher: name: Columbia University
Year: 2011
Subjects: Economics
Corporate state
Economic development
Economic development--Political aspects
Arab Spring (2010-)
Economic assistance

description: Four essays on addressing the demands of Arab Spring protestors for economic freedoms and opportunities: "Tunisians set off on the road from serfdom"; "Now for an Arab economic revolution"; "The corporatist threat to the Arab Spring"; and "Too much aid will hobble Arab Spring."
A Study on the Solar Illumination Provided by a Water Bottle
Creators: name: Pabari, Tejit V.
Publisher: name: Columbia University
Year: 2017
Subjects: Slums
Water bottles
Engineering
Skylights
Light

description: This paper provides experimental evidence to show that the “Litre of Light” (LOL) bottle is a better option than a glass plate covering the hole in the ceiling for providing sufficient illumination during daytime in congested settlements with insufficient illumination (slums). To model the room, a 70cm x 70 cm x 70 cm wooden box was constructed, and a 2liter coke bottle filled with drinking water was fixed to the roof of the box with 1/3rd of the bottle outside the box. The illuminance profile of the box floor was measured using a light sensor for different positions of the Sun in the sky from sunrise to sunset (by covering the roof hole first with LOL bottle, and then with glass plate). It was found that less than 0.7% of incident illuminance reaches the box floor after passing through the LOL bottle and less than 1.2% after passing through the glass plate. The LOL bottle was found to provide sufficient illumination for reading over a larger area of the room for a longer part of the day than a glass plate, in spite of the fact that the loss in illuminance when direct sunlight passes through a glass plate or a LOL bottle is very high. The peak intensity region was found to lie on diametrically opposite corners of the floor as compared to that found with a glass plate. This indicates the possibility of total internal reflection happening inside the LOL bottle.
Heterodimerization of ORL1 and opioid receptors and its consequences for N-type calcium channel regulation
Creators: name: You, Haitao
name: Hameed, Shahid
name: Altier, Christophe
name: Mezghrani, Alexandre
name: Bourinet, Emmanuel
name: Evans, Rhian M.
name: Zamponi, Gerald W.
Publisher: name: The American Society for Biochemistry and Molecular Biology, Inc.
Year: 2010

description: We have investigated the heterodimerization of ORL1 receptors and classical members of the opioid receptor family. All three classes of opioid receptors could be co-immunoprecipitated with ORL1 receptors from both transfected tsA-201 cell lysate and rat dorsal root ganglia lysate, suggesting that these receptors can form heterodimers. Consistent with this hypothesis, in cells expressing either one of the opioid receptors together with ORL1, prolonged ORL1 receptor activation via nociceptin application resulted in internalization of the opioid receptors. Conversely, mu-, delta-, and kappa-opioid receptor activation with the appropriate ligands triggered the internalization of ORL1. The mu-opioid receptor/ORL1 receptor heterodimers were shown to associate with N-type calcium channels, with activation of mu-opioid receptors triggering N-type channel internalization, but only in the presence of ORL1. Furthermore, the formation of opioid receptor/ORL1 receptor heterodimers attenuated the ORL1 receptor-mediated inhibition of N-type channels, in part because of constitutive opioid receptor activity. Collectively, our data support the existence of heterodimers between ORL1 and classical opioid receptors, with profound implications for effectors such as N-type calcium channels.
title: Vineyard Wind 1 (reinitiation to consider issuance of new MMPA IHA)
titleType: AlternativeTitle
title: National Marine Fisheries Service Endangered Species Act Section 7 Consultation Biological Opinion Construction, Operation, Maintenance, and Decommissioning of the Vineyard Wind 1 Offshore Energy Project (Lease OCS-A 0501) – Reinitiation
Creators: name: United States. National Marine Fisheries Service. Greater Atlantic Regional Fisheries Office
Publisher: name: United States. National Marine Fisheries Service. Greater Atlantic Regional Fisheries Office
Year: 2024

description: GARFO-2024-01318
Virtual Reference Assessment @ Columbia
Creators: name: Bielskas, Amanda S.
Publisher: name: Columbia University
Year: 2013
Subjects: Library science

description: The Columbia University Library has been offering the Ask-A-Librarian virtual reference service for many years. This poster analyzed the Ask-A-Librarian instant messaging (and text) use stats over the history of the service at Columbia University. In addition, for more recent years statistics collected with the LibraryH3lp native interface and those manually collected with Desk Tracker were also compared. The poster also illustrates how some of these use stats have been put to use in past assessment projects, and how some of this data could be used for future planning.
Analgesic effect of a mixed T-type channel inhibitor/CB2 receptor agonist
Creators: name: You, Haitao
name: Gadotti, Vinícius Maria
name: Petrov, Ravil R.
name: Berger, N. Daniel
name: Diaz, Philippe J.
name: Zamponi, Gerald W.
Publisher: name: BioMed Central Ltd.
Year: 2013

description: Cannabinoid receptors and T-type calcium channels are potential targets for treating pain. Here we report on the design, synthesis and analgesic properties of a new mixed cannabinoid/T-type channel ligand, NMP-181.
Common mechanisms of drug interactions with sodium and T-type calcium channels
Creators: name: Bladen, Chris
name: Zamponi, Gerald W.
Publisher: name: The American Society for Pharmacology and Experimental Therapeutics
Year: 2012

description: Voltage-gated sodium (Na(v)) and calcium (Ca(v)) channels play important roles in physiological processes, including neuronal and cardiac pacemaker activity, vascular smooth muscle contraction, and nociception. They are thought to share a common ancestry, and, in particular, T-type calcium (T-type) channels share structural similarities with Na(v) channels, both with regard to membrane topology and with regard to gating kinetics, including rapid inactivation. We thus reasoned that certain drugs acting on Na(v) channels may also modulate the activities of T-type channels. Here we show that the specific Na(v)1.8 blocker 5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide (A803467) tonically blocks T-type channels in the low micromolar range. Similarly to Na(v)1.8, this compound causes a significant hyperpolarizing shift in the voltage dependence of inactivation and seems to promote a slow inactivation-like phenotype. We further hypothesized that the structural similarity between T-type and Na(v) channels may extend to structurally similar drug-binding sites. Sequence alignment revealed several highly conserved regions between T-type and Na(v) channels that corresponded to drug-binding sites known to alter voltage-dependent gating kinetics. Mutation of amino acid residues in this regions within human Ca(v)3.2 T-type channels altered A803467 blocking affinity severalfold, suggesting that these sites may be exploited for the design of mixed T-type and Na(v) channel blockers that could potentially act synergistically to normalize aberrant neuronal activity.
On the BPS Spectrum at the Root of the Higgs Branch
Creators: name: Dorey, Nick
name: Petunin, Kirill
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the BPS spectrum and walls of marginal stability of the $\mathcal{N}=2$ supersymmetric theory in four dimensions with gauge group SU(n) and $n\le N_{f}<2n$ fundamental flavours at the root of the Higgs branch. The strong-coupling spectrum of this theory was conjectured in hep-th/9902134 to coincide with that of the two-dimensional supersymmetric $\mathbb{CP}^{2n-N_{f}-1}$ sigma model. Using the Kontsevich--Soibelman wall-crossing formula, we start with the conjectured strong-coupling spectrum and extrapolate it to all other regions of the moduli space. In the weak-coupling regime, our results precisely agree with the semiclassical analysis of hep-th/9902134: in addition to the usual dyons, quarks, and $W$ bosons, if the complex masses obey a particular inequality, the resulting weak-coupling spectrum includes a tower of bound states consisting of a dyon and one or more quarks. In the special case of $\mathbb{Z}_{n}$-symmetric masses, there are bound states with one quark for odd $n$ and no bound states for even $n$.
description: 11 pages, 4 figures
Supplementary material from Episodic, compression-driven fluid venting in layered sedimentary basins
Creators: name: Kearney, Luke M.
name: MacMinn, Christopher W.
name: Katz, Richard F.
name: Kirkham, Chris
name: Cartwright, Joe
Publisher: name: The Royal Society
Year: 2023
Subjects: subject: Geophysics
subject: FOS: Earth and related environmental sciences

description: Fluid venting phenomena are prevalent in sedimentary basins globally. Offshore, these localized fluid-expulsion events are archived in the geologic record by the resulting pockmarks at the sea-floor. Venting is widely interpreted to occur via hydraulic fracturing, which requires near-lithostatic pore pressures for initiation. One common driver for these extreme pressures is horizontal tectonic compression, which pressurizes the entire sedimentary column over a wide region. Fluid expulsion leads to a sudden, local relief of this pressure, which then gradually recharges through continued compression, leading to episodic venting. Pressure recharge will also occur through pressure diffusion from neighbouring regions that remain pressurized, but the combined role of compression and pressure diffusion in episodic venting has not previously been considered. Here, we develop a novel poroelastic model for episodic, compression-driven venting. We show that compression and pressure diffusion together set the resulting venting period. We derive a simple analytical expression for this venting period, demonstrating that pressure diffusion can significantly reduce the venting period associated with a given rate of compression. Our expression allows this rate of compression to be inferred from observations of episodic venting. We conclude that pressure diffusion is a major contributor to episodic fluid venting in mudstone-dominated basins.
Modelling and Design Methodology of High-Efficiency Harmonic Tuned Power Amplifiers for 5G Applications
Creators: name: Sharma, Tushar
Publisher: name: Graduate Studies
Year: 2018
Subjects: subject: Radio Frequency
subject: power amplifiers
subject: 5G
subject: Harmonic Tuned
subject: Active Load Pull
subject: Gallium Nitride
subject: Waveform Engineering
subject: Class F
subject: Inverse Class F
subject: Broadband
subject: Education--Sciences
subject: Engineering

description: Radio Frequency (RF) base station unit moves toward qualification of next generation gallium nitride devices to meet the expectation of fifth generation (5G) wireless communication transmitters. Critical to the enablement and the fulfilment of next-generation network energy efficiency, Power amplifiers (PAs) remain a centre of focus to RF power base station markets. With an immense increase in cellular traffic, the performance of PAs should be constantly improved in terms of power efficiency, linearity, and bandwidth. This thesis focuses on several aspects for enabling high efficiency and bandwidth for small cell PAs for 5G applications. A variety of PA design methodologies have been proposed and implemented to achieve state of the art performance. Innovative input and output controlled harmonic tuned PAs have been presented to enable application of advanced waveform engineering in RF base station products. Harmonic optimization techniques have been proposed for efficiency and bandwidth enhancement of the PA performance. For experimental validation, various prototypes for different peripheries, RF specifications, and targeted performance are fabricated using different technologies. The issues related to bandwidth extension, device reliability, and miniaturization of PA base unit are studied and mitigated. This thesis proposes a novel comprehensive analysis of harmonically tuned amplifiers with respect to input harmonic sensitivity, highlighting the significance of input and output controlled amplifiers and their impact on the linearity of gallium nitride (GaN) based high efficiency PAs. For the first time, this thesis presents class GF and GF-1 amplifiers which have demonstrated outstanding performance by simultaneously tackling both input and output harmonic. In particular, this work demonstrated methods for effective on wafer active load pull that minimizes the amount of time required on the measurement system, and how to directly achieve maximum efficiencies by a combination of fundamental, second, and third harmonic at load and source of the active device. The conventional problem of so-called 2nd harmonic efficiency “null”, has been addressed in this thesis. The study reveals new directions for harmonic load pull and design procedure for high-efficiency PAs, which enables PAs in context of wide bandwidth, high efficiency without compromising the quality of service.
DEVELOPMENT AND APPLICATION OF ARTIFICIALINTELLIGENCE, ROBOTICS AND VIRTUAL REALITY FOR ENHANCED CONDITION ASSESSMENT OFINFRASTRUCTURE IN SMART CITIES
Creators: name: Huang, Yu Ting
Publisher: name: Purdue University Graduate School
Year: 2023
Subjects: classificationCode: 400510
subject: Structural engineering

description: The roads in the US received a "D" grade on the 2021 report card for America's infrastructure by the American Society of Civil Engineers (ASCE). Poor road conditions generally translate into traffic accidents and vehicle damage, which result in additional expenses for drivers in terms of vehicle repairs and operating costs. To maintain a satisfactory pavement condition over an extended period of time, frequent inspections should be conducted, and any existing and imminent defects should be promptly addressed through corrective and preventive maintenance. However, the current practices are hindered by issues of inspectors' subjectivity, delayed responsiveness, and high costs. This study aims to develop innovative solutions that harness Artificial Intelligence (AI), robotics, and virtual reality (VR) to enhance pavement quality in smart cities.The study developed an autonomous system that relies on crowdsourced RGB and depth (RGB-D) data to assess road conditions. A cost-effective data acquisition system that can be mounted on multiple vehicles, was developed. Armed with a substantial dataset of RGB-D pavement surface data, this study explores the effectiveness of various depth-encoding techniques and RGB-D data fusion methods, using pothole detection as a case study. Comprehensive experiments were conducted to evaluate the effectiveness of defect detection using deep convolutional neural networks (DCNN). This study considered all major types of pavement defects in order to comprehensively evaluate pavement conditions. The Pavement Surface Evaluation Rating (PASER) for asphalt pavement is used as a case study. The establishment of an expert system for pavement condition evaluation involves the classification and quantification of pavement data. The system also facilitates the tracking of identified defects and repair work, providing up-to-date information on pavement deterioration and maintenance.Another aspect of this study is the improvement of pavement maintenance quality. To enhance the assessment of the effectiveness of pavement maintenance, this study developed immersive VR modules that provide technical staff with a supplementary platform for training. The training materials focus on two common types of pavement maintenance operations: crack sealing and patching. These modules include an interactive decision-making module for evaluating the quality of operations, as well as a hands-on task-performing module for crack sealing machinery preparation and the procedure of full-depth patching. This dissertation has revealed innovative approaches for integrating cutting-edge technologies into the assessment of pavement conditions. The proposed research aims to improve the safety,
Effect of biological activated carbon (BAC) filtration on the removal and biodegradation of natural organic matter (NOM)
Creators: name: Black, Kerry Elizabeth
Publisher: name: University of British Columbia
Year: 2011

description: Natural organic matter is a complex mixture of various organics including humic substances, carbohydrates, amino acids and carboxylic acids that exist in natural waters. Integrated treatment processes that combine oxidation processes and activated carbon biofilters have been shown to be effective at reducing natural organic matter (NOM) levels. The current research project investigated the effect of ozone and advanced oxidation at various doses on specific parameters including: biodegradability of NOM, formation of disinfection by-products (DBPs), change in apparent molecular weight (AMW) of NOM and dissolved organic carbon content (DOC). Overall, ozonation of the raw water at 2mg O₃/mg DOC resulted in significant reductions in aromatic material, resulting in lowered DBPFP. In addition, ozonation was successful at transforming NOM from high AMW to low AMW, rendering the organic material more biodegradable and preferentially removed during biofiltration. While the high-dose oxidants (ozonation at 25mg O₃/mg DOC and AOP treatment at 4000mJ/cm² and 10mg/L H₂0₂) were successful at reducing DOC, UVA, AMW and DBPFP, the elevated dose required make these options less realistic. Ozonation at 2mg O₃/mg DOC and AOP treatment at 2000mJ/cm² and 10mg/L H₂O₂ provide good reduction of UVA, AMW and DBPFP. The high dose oxidants are unsuitable as pre-treatment options for biofiltration given that they result in highly oxidized NOM that exhibited very little biodegradation during biofiltration. The lower dose oxidants are suitable pre-treatment options for biofiltration given the high reductions in UVA, AMW and DBPFP exhibited, and the similar biodegradation kinetics observed. Pre-oxidation prior to biofiltration is essential for removal of non-biodegradable DOC. The rate kinetics governing biodegradation were not sensitive to oxidant type or dose. Overall, this project provided beneficial insight into the operation of integrated treatment processes and the effect of these on several NOM characteristics including biodegradation.
Unifying structural and lexical case assignment in Dependent Case Theory
Creators: name: Puškar, Zorica
name: Müller, Gereon
Publisher: name: Zenodo
Year: 2019
Subjects: dependent case
Agree
dative

description: Dependent Case Theory argues against case assignment via a functional head (cf.

Chomsky 2000; 2001) and proposes instead that case is a result of a structural rela-

tion between two DPs (Marantz 1991; McFadden 2004; Baker & Vinokurova 2010;

Baker 2015). However, Dependent Case Theory cannot completely abandon case as-

signment via a syntactic head, as this mechanism accounts for lexical case (e.g. lex-

ical dative). Furthermore, structural and lexical datives are morphologically identi-

cal and often behave similarly, and ‘just where the line should be drawn between

the two is a theoretical matter’ (Baker 2015: 13). We argue for a unified approach

to lexical and structural dative case assignment under Dependent Case Theory, im-

plemented in a derivational fashion, via the operation Agree. While structural dat

is assigned as a high dependent case in the VP in the presence of a lower (later acc)

DP, lexical dat is assigned in the same configuration, in the VP, in the presence of

another silent or overt co-argument DP.
Disruption of NMDAR-CRMP-2 signaling protects against focal cerebral ischemic damage in the rat middle cerebral artery occlusion model
Creators: name: Pan, Rui
name: You, Haitao
name: Brustovetsky, Tatiana
name: Khanna, Rajesh
name: Brittain, Joel M.
name: Brustovetsky, Nickolay N.
name: Zamponi, Gerald W.
name: Lee, Weihua
Publisher: name: Landes Bioscience
Year: 2012

description: Collapsin response mediator protein 2 (CRMP-2), traditionally viewed as an axon/dendrite specification and axonal growth protein, has emerged as nidus in regulation of both pre- and post-synaptic Ca ( 2+) channels. Building on our discovery of the interaction and regulation of Ca ( 2+) channels by CRMP-2, we recently identified a short sequence in CRMP-2 which, when appended to the transduction domain of HIV TAT protein, suppressed acute, inflammatory and neuropathic pain in vivo by functionally uncoupling CRMP-2 from the Ca ( 2+) channel. Remarkably, we also found that this region attenuated Ca ( 2+) influx via N-methylD-Aspartate receptors (NMDARs) and reduced neuronal death in a moderate controlled cortical impact model of traumatic brain injury (TBI). Here, we sought to extend these findings by examining additional neuroprotective effects of this peptide (TAT-CBD3) and exploring the biochemical mechanisms by which TAT-CBD3 targets NMDARs. We observed that an intraperitoneal injection of TAT-CBD3 peptide significantly reduced infarct volume in an animal model of focal cerebral ischemia. Neuroprotection was observed when TAT-CBD3 peptide was given either prior to or after occlusion but just prior to reperfusion. Surprisingly, a direct biochemical complex was not resolvable between the NMDAR subunit NR2B and CRMP-2. Intracellular application of TAT-CBD3 failed to inhibit NMDAR current. NR2B interactions with the post synaptic density protein 95 (PSD-95) remained intact and were not disrupted by TAT-CBD3. Peptide tiling of intracellular regions of NR2B revealed two 15-mer sequences, in the carboxyl-terminus of NR2B, that may confer binding between NR2B and CRMP-2 which supports CRMP-2's role in excitotoxicity and neuroprotection.