title: ÐÐ·Ð¼ÐµÑÑÐµÐ¼ÑÐ¹ ÐºÐ¾ÑÑÑÐ¸ÑÐ¸ÐµÐ½Ñ Ð´Ð¸ÑÑÑÐ·Ð¸Ð¸ ÐºÐ°Ðº Ð¿Ð¾ÑÐµÐ½ÑÐ¸Ð°Ð»ÑÐ½ÑÐ¹ Ð±Ð¸Ð¾Ð¼Ð°ÑÐºÐµÑ Ð¾ÑÐ²ÐµÑÐ° Ð¾Ð¿ÑÑ Ð¾Ð»Ð¸ Ð½Ð° ÑÐ°Ð´Ð¸Ð¾Ñ Ð¸ÑÑÑÐ³Ð¸ÑÐµÑÐºÐ¾Ðµ Ð»ÐµÑÐµÐ½Ð¸Ðµ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Apparent diffusion coefficient as a potential biomarker for tumor response to radiosurgical treatment
Creators: name: ÐÐµÐ²Ð¾Ð¹Ñ, ÐÐ°ÑÐ¸Ð»Ð¸ÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: ÐÐ¸ÑÑÑÐ·Ð¸Ñ
ÐÐ¸Ð¾ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸Ñ
Ð¸Ð·Ð¼ÐµÑÑÐµÐ¼ÑÐ¹ ÐºÐ¾ÑÑÑÐ¸ÑÐ¸ÐµÐ½Ñ Ð´Ð¸ÑÑÑÐ·Ð¸Ð¸
Ð´Ð¸ÑÑÑÐ·Ð¸Ð¾Ð½Ð½Ð¾-Ð²Ð·Ð²ÐµÑÐµÐ½Ð½Ð°Ñ Ð¼ÑÑ
Ð¼ÐµÑÐ°ÑÑÐ°Ð·Ñ Ð² Ð³Ð¾Ð»Ð¾Ð²Ð½Ð¾Ð¹ Ð¼Ð¾Ð·Ð³
ÑÐ°Ð´Ð¸Ð¾Ñ Ð¸ÑÑÑÐ³Ð¸Ñ
Ð³Ð¸Ð¿Ð¾ÑÑÐ°ÐºÑÐ¸Ð¾Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
Ð¾ÑÐ²ÐµÑ Ð¾Ð¿ÑÑ Ð¾Ð»Ð¸ Ð½Ð° Ð»ÐµÑÐµÐ½Ð¸Ðµ
apparent diffusion coefficient
diffusion-weighed mri
brain metastases
radiosurgery
hypofractionation
tumor response

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð²Ð»Ð¸ÑÐ½Ð¸Ñ Ð´Ð¸ÑÑÑÐ·Ð¸Ð¾Ð½Ð½ÑÑ Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÐ¾Ð² Ð¼ÐµÑÐ°ÑÑÐ°ÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¾ÑÐ°Ð³Ð¾Ð² Ð² Ð³Ð¾Ð»Ð¾Ð²Ð½Ð¾Ð¼ Ð¼Ð¾Ð·Ð³Ðµ Ð´Ð¾ Ð¸ Ð¿Ð¾ÑÐ»Ðµ ÑÐ°Ð´Ð¸Ð¾ÑÐ¸ÑÑÑÐ³Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð»ÐµÑÐµÐ½Ð¸Ñ Ð² ÑÐµÐ¶Ð¸Ð¼Ðµ Ð³Ð¸Ð¿Ð¾ÑÑÐ°ÐºÑÐ¸Ð¾Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð½Ð° Ð¾ÑÐ²ÐµÑ Ð¾Ð¿ÑÑÐ¾Ð»Ð¸. ÐÑÐ» Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½ ÑÐµÑÑÐ¾ÑÐ¿ÐµÐºÑÐ¸Ð²Ð½ÑÐ¹ Ð°Ð½Ð°Ð»Ð¸Ð· ÐÐ -Ð¸Ð·Ð¾Ð±ÑÐ°Ð¶ÐµÐ½Ð¸Ð¹ Ð¸ Ð»ÐµÑÐµÐ±Ð½ÑÑ Ð¿Ð»Ð°Ð½Ð¾Ð² Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð², ÐºÐ¾ÑÐ¾ÑÑÐ¼ Ð±ÑÐ»Ð¾ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¾ ÑÐ°Ð´Ð¸Ð¾ÑÐ¸ÑÑÑÐ³Ð¸ÑÐµÑÐºÐ¾Ðµ Ð»ÐµÑÐµÐ½Ð¸Ðµ Ð² ÑÐµÐ¶Ð¸Ð¼Ðµ Ð³Ð¸Ð¿Ð¾ÑÑÐ°ÐºÑÐ¸Ð¾Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ. ÐÐ½Ð°ÑÐµÐ½Ð¸Ñ Ð¸Ð·Ð¼ÐµÑÑÐµÐ¼Ð¾Ð³Ð¾ ÐºÐ¾ÑÑÑÐ¸ÑÐ¸ÐµÐ½ÑÐ° Ð´Ð¸ÑÑÑÐ·Ð¸Ð¸ Ð¼ÐµÑÐ°ÑÑÐ°ÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¾ÑÐ°Ð³Ð¾Ð² Ð±ÑÐ»Ð¸ Ð¿Ð¾Ð»ÑÑÐµÐ½Ñ Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ ÑÐ²Ð¾Ð±Ð¾Ð´Ð½Ð¾ ÑÐ°ÑÐ¿ÑÐ¾ÑÑÑÐ°Ð½ÑÐµÐ¼Ð¾Ð³Ð¾ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð¾Ð³Ð¾ Ð¾Ð±ÐµÑÐ¿ÐµÑÐµÐ½Ð¸Ñ 3D Slicer. ÐÑÐ» Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½ ÑÑÐ°ÑÐ¸ÑÑÐ¸ÑÐµÑÐºÐ¸Ð¹ Ð°Ð½Ð°Ð»Ð¸Ð· Ð´Ð»Ñ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐ»ÐµÐ´ÑÑÑÐ¸Ñ Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÐ¾Ð²: ÑÐ²ÑÐ·Ð¸ Ð¸Ð·Ð¼ÐµÑÑÐµÐ¼Ð¾Ð³Ð¾ ÐºÐ¾ÑÑÑÐ¸ÑÐ¸ÐµÐ½ÑÐ° Ð´Ð¸ÑÑÑÐ·Ð¸Ð¸ Ñ ÐºÐ»Ð¸Ð½Ð¸ÑÐµÑÐºÐ¸Ð¼Ð¸ Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÐ°Ð¼Ð¸ Ð¾ÑÐ°Ð³Ð¾Ð² Ð¸ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸ÐºÐ°Ð¼Ð¸ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð², Ð´Ð¸Ð½Ð°Ð¼Ð¸ÐºÐ¸ Ð¸Ð·Ð¼ÐµÑÑÐµÐ¼Ð¾Ð³Ð¾ ÐºÐ¾ÑÑÑÐ¸ÑÐ¸ÐµÐ½ÑÐ° Ð´Ð¸ÑÑÑÐ·Ð¸Ð¸ Ð¿Ð¾ÑÐ»Ðµ Ð²ÑÑÐ¾ÐºÐ¾Ð´Ð¾Ð·Ð½Ð¾Ð³Ð¾ ÑÑÐµÑÐµÐ¾ÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¾Ð±Ð»ÑÑÐµÐ½Ð¸Ñ Ð² ÐºÑÐ°ÑÐºÐ¾ÑÑÐ¾ÑÐ½Ð¾Ð¼ Ð¿ÐµÑÐ¸Ð¾Ð´Ðµ Ð¸ ÐµÐµ Ð²Ð·Ð°Ð¸Ð¼Ð¾ÑÐ²ÑÐ·Ñ Ñ Ð´Ð¸Ð½Ð°Ð¼Ð¸ÐºÐ¾Ð¹ Ð¾Ð±ÑÐµÐ¼Ð° Ð¾Ð¿ÑÑÐ¾Ð»Ð¸, Ð¿ÑÐ¾Ð³Ð½Ð¾ÑÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð·Ð½Ð°ÑÐ¸Ð¼Ð¾ÑÑÐ¸ Ð¸Ð·Ð¼ÐµÑÑÐµÐ¼Ð¾Ð³Ð¾ ÐºÐ¾ÑÑÑÐ¸ÑÐ¸ÐµÐ½ÑÐ° Ð´Ð¸ÑÑÑÐ·Ð¸Ð¸ Ð² Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ð¸ Ð²Ð¾Ð»ÑÐ¼ÐµÑÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¾ÑÐ²ÐµÑÐ° Ð¾Ð¿ÑÑÐ¾Ð»Ð¸, Ð»Ð¾ÐºÐ°Ð»ÑÐ½Ð¾Ð³Ð¾ ÐºÐ¾Ð½ÑÑÐ¾Ð»Ñ Ð¸ Ð¾ÑÐ´Ð°Ð»ÐµÐ½Ð½ÑÑ Ð»ÑÑÐµÐ²ÑÑ ÑÐµÐ°ÐºÑÐ¸Ð¹. Ð ÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð»Ð¸, ÑÑÐ¾ Ð¸Ð·Ð¼ÐµÑÑÐµÐ¼ÑÐ¹ ÐºÐ¾ÑÑÑÐ¸ÑÐ¸ÐµÐ½Ñ Ð´Ð¸ÑÑÑÐ·Ð¸Ð¸ Ð¼Ð¾Ð¶ÐµÑ ÑÐ»ÑÐ¶Ð¸ÑÑ Ð´Ð¾Ð¿Ð¾Ð»Ð½Ð¸ÑÐµÐ»ÑÐ½Ð¾Ð¹ ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²ÐµÐ½Ð½Ð¾Ð¹ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸ÐºÐ¾Ð¹ Ð¼ÐµÑÐ°ÑÑÐ°ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð¾Ð¿ÑÑÐ¾Ð»Ð¸ Ð¸ Ð´Ð°ÐµÑ Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½Ð¾ÑÑÑ Ð¿ÑÐµÐ´ÑÐºÐ°Ð·ÑÐ²Ð°ÑÑ Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½ÑÐ¹ Ð¾ÑÐ²ÐµÑ Ð¾Ð¿ÑÑÐ¾Ð»Ð¸ Ð½Ð° Ð¾Ð±Ð»ÑÑÐµÐ½Ð¸Ðµ.Â 
description: The given work is devoted to the study of the diffusion parameters of brain metastases before and after hypofractionated radiosurgery on the tumor response. A retrospective analysis of MR images and treatment plans of patients who underwent radiosurgical treatment in hypofractionation mode was made. The values ââof the apparent diffusion coefficient of metastatic tumors were measured using 3D Slicer. Statistical analysis was made to study the following parameters: the relationship of the apparent diffusion coefficient with the clinical parameters of lesions and patient characteristics, the dynamics of the apparent diffusion coefficient after high-dose stereotactic irradiation in the short term and its relationship with the tumor volume dynamics, the prognostic significance of the apparent diffusion coefficient in relation to the volumetric tumor response, local control and long-term complications of radiotherapy. The results showed that the apparent diffusion coefficient can serve as an additional quantitative parameter of a metastatic tumor and possibly can predict the tumor response to high-dose radiation therapy.