cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Orally delivered rutin in lipid-based nano-formulation exerts strong antithrombotic effects by protein disulfide isomerase inhibition
Creators: name: Chen, Dan
name: Liu, Yurong
name: Liu, Peiwen
name: Zhou, Yang
name: Jiang, Longguang
name: Yuan, Cai
name: Huang, Mingdong
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biochemistry
Medicine
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Hematology

description: Thrombosis occurs in both macrovasculature and microvasculature, causing various cardio-cerebral vascular diseases. The lack of effective and safe antithrombotic drugs leads to a public health crisis. Mounting evidence suggests that protein disulfide isomerase (PDI) plays a critical role in the initial stage of thrombus formation, motivating the research of the feasibility of PDI inhibitors as novel anti-thrombotics. Rutin, one of the most potent PDI inhibitors, was reported to suppress platelet aggregation and thrombosis in animal models, but further studies and clinical translation were restricted due to its low aqueous solubility and oral bioavailability. In this work, we fabricated rutin-loaded lipid-based nano-formulation (NanoR) and characterized their physical–chemical properties, release profiles, pharmacokinetic process, and pharmacodynamic function against thrombosis in macrovessels and microvessels. NanoR provided increased solubility and dissolution of rutin to achieve earlier Tmax and higher Cmax than the sodium salt of rutin (NaR) after oral gavage. Ex vivo studies demonstrated that NanoR significantly inhibited thrombin generation and clot formation in the plasma of mice. Importantly, such effect was reversed by exogenous recombinant PDI, demonstrating the specificity of the NanoR. In direct current-induced arterial thrombosis model and ferric chloride-induced microvascular thrombosis model, NanoR exhibited greatly enhanced antithrombotic activity compared with NaR. NanoR also showed good safety performance according to tail bleeding assay, global coagulation tests, and histological analysis. Overall, our current results indicated that NanoR offers a promising antithrombotic treatment with potential for clinical translation.
TALABA-YOSHLARNI YETUKLIKKA YO'NALTIRISHDA SO'FI OLLOYOR TALQININING XUSUSIYATLARI
Creators: name: Kotibov, Rustamxon
Publisher: name: Zenodo
Year: 2025

description: Ushbu maqolada talaba-yoshlarni har tomonlama yetuklikka yo‘naltirishda So‘fi Olloyorning ijodiy merosi va uning dunyoqarashi qanday xususiyatlarga ega ekani tahlil etiladi. Maqolada bir tomondan So‘fi Olloyorning she’rlari va pand-nasihatlaridagi ma’naviy-axloqiy g‘oyalar yoritilsa, ikkinchi tomondan ularni zamonaviy talaba-yoshlar tarbiyasiga tadbiq etish imkoniyatlariga e’tibor qaratiladi. Shoir asarlarining xalqchil uslubda yozilgani, tarbiyaviy mazmuni chuqurligi hamda yoshlarni yetuk shaxs sifatida shakllantirishda taklif qilgan ta’limiy yondashuvi talqin qilinadi. Bunda So‘fi Olloyorning xoksorlik, adolat, halollik, ilm-ma’rifatga intilish kabi fazilatlarni targ‘ib etishi, zamonaviy ma’naviy-ma’rifiy jarayonda ayniqsa dolzarb ekani ilmiy dalillar bilan asoslab beriladi.
Chitosan-modified hollow manganese dioxide nanoparticles loaded with resveratrol for the treatment of spinal cord injury
Creators: name: Li, Yingqiao
name: Zou, Zhiru
name: An, Jinyu
name: Wu, Qian
name: Tong, Le
name: Mei, Xifan
name: Tian, He
name: Wu, Chao
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biochemistry
Medicine
Cell Biology
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Science Policy

description: Spinal cord injury (SCI) is a serious central nervous system disease, and secondary injury, including oxidative stress, the inflammatory response and accompanying neuronal apoptosis, will aggravate the condition. Due to the existence of the blood–spinal cord barrier (BSCB), the existing drugs for SCI treatment are difficulty to reach the injury site and thus their efficacy is limited. In this study, we designed chitosan-modified hollow manganese dioxide nanoparticles (CM) for the delivery of resveratrol to help it pass through the BSCB. Resveratrol (Res), a poorly soluble drug, was adsorbed into CM with a particle size of approximately 130 nm via the adsorption method, and the drug loading reached 21.39 ± 2.53%. In vitro dissolution experiment, the Res release of the loaded sample (CMR) showed slowly release behavior and reached about 87% at 36 h. In vitro at the cellular level and in vivo at the animal level experiments demonstrated that CMR could alleviate significantly oxidative stress by reducing level of reactive oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD), and increasing glutathione peroxidase (GSH) level. Additionally, immunofluorescence (iNOS, IL-1β, and Cl caspase-3) and western blot (iNOS, cox-2, IL-1β, IL-10, Cl caspase-3, bax, and bcl-2) were used to detect the expression of related factors, which verified that CMR could also reduce inflammation and neuronal apoptosis. These results indicated that CM, as a potential central nervous system drug delivery material, was suitable for SCI treatment.
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VIII, Cart. 192 (11 H 77), 295 folios, f. 0127v
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VIII, Archives départementales de la Côte-d'Or, Cart. 192 (11 H 77), 295 folios, f. 0127v, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VIII, Archives départementales de la Côte-d'Or, Cart. 192 (11 H 77), 295 folios, f. 0127v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Instanton effects in correlation functions on the light-cone
Creators: name: Korchemsky, G. P.
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study instanton corrections to four-point correlation correlation function of half-BPS operators in $\mathcal N=4$ SYM in the light-cone limit when operators become null separated in a sequential manner. We exploit the relation between the correlation function in this limit and light-like rectangular Wilson loop to determine the leading instanton contribution to the former from the semiclassical result for the latter. We verify that the light-like rectangular Wilson loop satisfies anomalous conformal Ward identities nonperturbatively, in the presence of instantons. We then use these identities to compute the leading instanton contribution to the light-like cusp anomalous dimension and to anomalous dimension of twist-two operators with large spin.
description: 27 pages
Functionalized chitosan nanoparticles for cutaneous delivery of a skin whitening agent: an approach to clinically augment the therapeutic efficacy for melasma treatment
Creators: name: Hatem, Shymaa
name: Elkheshen, Seham A.
name: Kamel, Amany O.
name: Nasr, Maha
name: Moftah, Noha H.
name: Ragai, Maha H
name: Elezaby, Reham S.
name: Hoffy, Nada M. El
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Space Science
Medicine
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Developmental Biology
Cancer

description: The increase in the production of melanin level inside the skin prompts a patient-inconvenient skin color disorder namely; melasma. This arouses the need to develop efficacious treatment modalities, among which are topical nano-delivery systems. This study aimed to formulate functionalized chitosan nanoparticles (CSNPs) in gel form for enhanced topical delivery of alpha-arbutin as a skin whitening agent to treat melasma. Ionic gelation method was employed to prepare α-arbutin-CSNPs utilizing a 24 full factorial design followed by In vitro, Ex vivo and clinical evaluation of the nano-dispersions and their gel forms. Results revealed that the obtained CSNPs were in the nanometer range with positive zeta potential, high entrapment efficiency, good stability characteristics and exhibited sustained release of α-arbutin over 24 h. Ex vivo deposition of CSNPs proved their superiority in accumulating the drug in deep skin layers with no transdermal delivery. DSC and FTIR studies revealed the successful amorphization of α-arbutin into the nanoparticulate system with no interaction between the drug and the carrier system. The comparative split-face clinical study revealed that α-arbutin loaded CSNPs hydrogels showed better therapeutic efficacy compared to the free drug hydrogel in melasma patients, as displayed by the decrease in: modified melasma area and severity index (mMASI) scores, epidermal melanin particle size surface area (MPSA) and the number of epidermal monoclonal mouse anti–melanoma antigen recognized by T cells-1 (MART-1) positive cells which proved that the aforementioned system is a promising modality for melasma treatment.
Additional file 1 of Survival past five years with advanced, EGFR-mutated or ALK-rearranged non-small cell lung cancer—is there a “tail plateau” in the survival curve of these patients?
Creators: name: Shimamura, Shoko Sonobe
name: Shukuya, Takehito
name: Asao, Tetsuhiko
name: Hayakawa, Daisuke
name: Kurokawa, Kana
name: Xu, Shiting
name: Miura, Keita
name: Mitsuishi, Yoichiro
name: Tajima, Ken
name: Shibayama, Rina
name: Shimada, Naoko
name: Takahashi, Fumiyuki
name: Takahashi, Kazuhisa
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1:Supplemental Table 1. Distribution of EGFR mutation.
Additional file 10: of The microRNA-15a-PAI-2 axis in cholangiocarcinoma-associated fibroblasts promotes migration of cancer cells
Creators: name: Penkhae Utaijaratrasmi
name: Kulthida Vaeteewoottacharn
name: Tsunematsu, Takaaki
name: Pranisa Jamjantra
name: Sopit Wongkham
name: Chawalit Pairojkul
name: Narong Khuntikeo
name: Naozumi Ishimaru
name: Yongyut Sirivatanauksorn
name: Ananya Pongpaibul
name: Thuwajit, Peti
name: Chanitra Thuwajit
name: Yasusei Kudo
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Supplementary information of the invasion assay method. (DOCX 12Â kb)
Additional file 1: of Does different information disclosure on placebo control affect blinding and trial outcomes? A case study of participant information leaflets of randomized placebo-controlled trials of acupuncture
Creators: name: Soyeon Cheon
name: Hi-Joon Park
name: Younbyoung Chae
name: Hyangsook Lee
Publisher: name: figshare
Year: 2018
Subjects: Medicine
Science Policy
Computational Biology

description: Appendix 1. Demographics of collected PILs. Appendix 2. Placebo control groups in the included studies. Appendix 3. Characteristics of the included studies. Appendix 4. Description of placebo acupunctures in PILs. Appendix 5. How different regions describe placebo acupuncture differently. Appendix 6. A post-hoc subgroup analysis between studies from Asian and non-Asian countries. (DOCX 3144Â kb)
Additional file 1 of WD40 repeat 43 mediates cell survival, proliferation, migration and invasion via vimentin in colorectal cancer
Creators: name: Li, Zijian
name: Feng, Min
name: Zhang, Jie
name: Wang, Xingzhou
name: Xu, En
name: Wang, Chao
name: Lin, Fengcen
name: Yang, Zhi
name: Yu, Heng
name: Guan, Wenxian
name: Wang, Hao
Publisher: name: figshare
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1. The sequence of VIM overexpression.
Docetaxel prodrug and hematoporphyrin co-assembled nanoparticles for anti-tumor combination of chemotherapy and photodynamic therapy
Creators: name: Ren, Guolian
name: Li, Yujie
name: Ping, Canqi
name: Duan, Danyu
name: Li, Ning
name: Tang, Jiaqi
name: Wang, Rongrong
name: Guo, Wenju
name: Niu, Xiaomin
name: Ji, Qiuyue
name: Zhang, Guoshun
name: Wang, Ruili
name: Zhang, Shuqiu
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: To realize the synergistic anti-tumor effect of chemotherapy and photodynamic therapy, the mono sulfide-modified docetaxel (DTX) prodrugs (DSD) provided by our laboratory and hematoporphyrin (HP) were used to physically prepare co-assembled nanoparticles (DSD/HP NPs) by nano-precipitation. For the first time, this study showed its characteristics, in vitro anti-tumor activity, pharmacokinetic behavior in rats, in vivo distribution, and pharmacodynamic effects on 4T1 tumor-bearing Bal b/c mice. DSD/HP NPs optimized by single-factor and response surface optimization had several distinct characteristics. First, it had dark purple appearance with particle size of 105.16 ± 1.24 nm, PDI of 0.168 ± 0.15, entrapment efficiency and drug loading of DSD and HP in DSD/HP NPs of 96.27 ± 1.03% and 97.70 ± 0.20%, 69.22 ± 1.03% and 20.03 ± 3.12%, respectively. Second, it had good stability and could release DTX and HP slowly in the media of pH 7.4 PBS with 10 mM DTT (H2O2). Moreover, DSD/HP NPs along with NiR treatment significantly inhibited 4T1 cells proliferation, and induced more reactive oxygen species and cells apoptosis. In vivo pharmacokinetic and pharmacodynamic studies showed that DSD/HP NPs could prolong the drug circulation time in rats, increase drug distribution in tumor site, obviously inhibit tumor growth, and decrease the exposure of drug to normal tissues. Therefore, DSD/HP NPs as a promising co-assembled nano-drug delivery system could potentially improve the therapeutic efficiency of chemotherapeutic drug and achieve better anti-tumor effects due to the combination of chemotherapy and photodynamic therapy.
Distant total irregularity strength of graphs via random vertex ordering
Creators: name: Przybyło, Jakub
Publisher: name: arXiv
Year: 2017
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: Let $c:V\cup E\to\{1,2,\ldots,k\}$ be a (not necessarily proper) total colouring of a graph $G=(V,E)$ with maximum degree $Δ$. Two vertices $u,v\in V$ are sum distinguished if they differ with respect to sums of their incident colours, i.e. $c(u)+\sum_{e\ni u}c(e)\neq c(v)+\sum_{e\ni v}c(e)$. The least integer $k$ admitting such colouring $c$ under which every $u,v\in V$ at distance $1\leq d(u,v)\leq r$ in $G$ are sum distinguished is denoted by ${\rm ts}_r(G)$. Such graph invariants link the concept of the total vertex irregularity strength of graphs with so called 1-2-Conjecture, whose concern is the case of $r=1$. Within this paper we combine probabilistic approach with purely combinatorial one in order to prove that ${\rm ts}_r(G)\leq (2+o(1))Δ^{r-1}$ for every integer $r\geq 2$ and each graph $G$, thus improving the previously best result: ${\rm ts}_r(G)\leq 3Δ^{r-1}$.
description: 8 pages
Additional file 2 of Survival past five years with advanced, EGFR-mutated or ALK-rearranged non-small cell lung cancer—is there a “tail plateau” in the survival curve of these patients?
Creators: name: Shimamura, Shoko Sonobe
name: Shukuya, Takehito
name: Asao, Tetsuhiko
name: Hayakawa, Daisuke
name: Kurokawa, Kana
name: Xu, Shiting
name: Miura, Keita
name: Mitsuishi, Yoichiro
name: Tajima, Ken
name: Shibayama, Rina
name: Shimada, Naoko
name: Takahashi, Fumiyuki
name: Takahashi, Kazuhisa
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2.
Additional file 1: Dataset 1. of A reverse vaccinology approach to the identification and characterization of Ctenocephalides felis candidate protective antigens for the control of cat flea infestations
Creators: name: Contreras, Marinela
name: Villar, Margarita
name: Artigas-Jerónimo, Sara
name: Lidiia Kornieieva
name: Sergіі Mуtrofanov
name: Fuente, José De La
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Sequences of predicted transmembrane and secreted proteins encoded in the transcriptome and used for PIT. (PDF 303 kb)
The large-scale nebular pattern of a superwind binary in an eccentric orbit
Creators: name: Kim, Hyosun
name: Trejo, Alfonso
name: Liu, Sheng-Yuan
name: Sahai, Raghvendra
name: Taam, Ronald E.
name: Morris, Mark R.
name: Hirano, Naomi
name: Hsieh, I-Ta
Publisher: name: arXiv
Year: 2017
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Preplanetary nebulae and planetary nebulae are evolved, mass-losing stellar objects that show a wide variety of morphologies. Many of these nebulae consist of outer structures that are nearly spherical (spiral/shell/arc/halo) and inner structures that are highly asymmetric (bipolar/multipolar). The coexistence of such geometrically distinct structures is enigmatic because it hints at the simultaneous presence of both wide and close binary interactions, a phenomenon that has been attributed to stellar binary systems with eccentric orbits. Here we report new high-resolution molecular-line observations of the circumstellar spiral-shell pattern of AFGL 3068, an asymptotic giant branch star transitioning to the preplanetary nebula phase. The observations clearly reveal that the dynamics of the mass loss is influenced by the presence of an eccentric-orbit binary. This quintessential object opens a new window on the nature of deeply embedded binary stars through the circumstellar spiral-shell patterns that reside at distances of several thousand Astronomical Units from the stars.
description: Published in Nature Astronomy (cover story of the March issue, 2017), Authors' edited version (17 pages, 3 main figures, 4 supplementary figures, and 1 supplementary video)
title: ADCO, Deuxième cartulaire ou Grand cartulaire de l'abbaye de Molesme, Cart. 143 (7 H 7), 153 fol, f. 0004v
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: Petot, Frédéric
name: CG21/F.PETOT/2009
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Deuxième cartulaire ou Grand cartulaire de l'abbaye de Molesme, Archives départementales de la Côte-d'Or, Cart. 143 (7 H 7), 153 fol, f. 0004v, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Deuxième cartulaire ou Grand cartulaire de l'abbaye de Molesme, Archives départementales de la Côte-d'Or, Cart. 143 (7 H 7), 153 fol, f. 0004v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb137389344
description: Provenance: abbaye de Molesme
description: Provenance: http://www.wikidata.org/entity/Q334044
Additional file 1: of Causes of death in hospitalized children younger than 12Â years of age in a Chinese hospital: a 10Â year study
Creators: name: Yueniu Zhu
name: Xiaodong Zhu
name: Mengyan Deng
name: Hongxia Wei
name: Mingjun Zhang
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology
subject: Science Policy
subject: 60506 Virology
subject: Computational Biology

description: Disease category. (DOC 36Â kb)
Perturbative Thermodynamic Geometry of Nonextensive Ideal Classical, Bose and Fermi Gases
Creators: name: Mohammadzadeh, Hosein
name: Adli, Fereshteh
name: Nouri, Sahereh
Publisher: name: arXiv
Year: 2017
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We investigate perturbative thermodynamic geometry of nonextensive ideal Classical, Bose and Fermi gases.We show that the intrinsic statistical interaction of nonextensive Bose (Fermi) gas is attractive (repulsive) similar to the extensive case but the value of thermodynamic curvature is changed by nonextensive parameter. In contrary to the extensive ideal classical gas, the nonextensive one may be divided to two different regimes. According to deviation parameter of the system to the nonextensive case, one can find a special value of fugacity, $z^{*}$, where the sign of thermodynamic curvature is changed. Therefore, we argue that the nonextensive parameter induces an attractive (repulsive) statistical interaction for $zz^{*}$) for an ideal classical gas. Also, according to the singular point of thermodynamic curvature, we consider the condensation of nonextensive Boson gas.
description: 8 pages, 5 figures, Phys. Rev. E (2016)
Anomalous diffusion on a fractal mesh
Creators: name: Sandev, Trifce
name: Iomin, Alexander
name: Kantz, Holger
Publisher: name: arXiv
Year: 2016
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: An exact analytical analysis of anomalous diffusion on a fractal mesh is presented. The fractal mesh structure is a direct product of two fractal sets which belong to a main branch of backbones and side branch of fingers. The fractal sets of both backbones and fingers are constructed on the entire (infinite) $y$ and $x$ axises. To this end we suggested a special algorithm of this special construction. The transport properties of the fractal mesh is studied, in particular, subdiffusion along the backbones is obtained with the dispersion relation $\langle x^2(t)\rangle\sim t^β$, where the transport exponent $β<1$ is determined by the fractal dimensions of both backbone and fingers. Superdiffusion with $β>1$ has been observed as well when the environment is controlled by means of a memory kernel.
Icaritin-loaded PLGA nanoparticles activate immunogenic cell death and facilitate tumor recruitment in mice with gastric cancer
Creators: name: Xiao, Yao
name: Yao, Wenxia
name: Lin, Mingzhen
name: Huang, Wei
name: Li, Ben
name: Peng, Bin
name: Ma, Qinhai
name: Zhou, Xinke
name: Liang, Min
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: This study aimed to explore the anti-tumor effect of icaritin loading poly (lactic-co-glycolic acid) nanoparticles (refer to PLGA@Icaritin NPs) on gastric cancer (GC) cells. Transmission Electron Microscope (TEM), size distribution, zeta potential, drug-loading capability, and other physicochemical characteristics of PLGA@Icaritin NPs were carried out. Furthermore, flow cytometry, confocal laser scanning microscope (CLSM), Cell Counting Kit-8 (CCK-8), Transwell, Elisa assay and Balb/c mice were applied to explore the cellular uptake, anti-proliferation, anti-metastasis, immune response activation effects, and related anti-tumor mechanism of PLGA@Icaritin NPs in vitro and in vivo. PLGA@Icaritin NPs showed spherical shape, with appropriate particle sizes and well drug loading and releasing capacities. Flow cytometry and CLSM results indicated that PLGA@Icaritin could efficiently enter into GC cells. CCK-8 proved that PLGA@Icaritin NPs dramatically suppressed cell growth, induced Lactic dehydrogenase (LDH) leakage, arrested more GC cells at G2 phase, and inhibited the invasion and metastasis of GC cells, compared to free icaritin. In addition, PLGA@Icaritin could help generate dozens of reactive oxygen species (ROS) within GC cells, following by significant mitochondrial membrane potentials (MMPs) loss and excessive production of oxidative-mitochondrial DNA (Ox-mitoDNA). Since that, Ox-mitoDNA further activated the releasing of damage associated molecular pattern molecules (DAMPs), and finally led to immunogenic cell death (ICD). Our in vivo data also elaborated that PLGA@Icaritin exerted a powerful inhibitory effect (∼80%), compared to free icaritin (∼60%). Most importantly, our results demonstrated that PLGA@Icaritin could activate the anti-tumor immunity via recruitment of infiltrating CD4+ cells, CD8+ T cells and increased secretion of cytokine immune factors, including interferon-γ (IFN-γ) tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1).++ Our findings validate that the successful design of PLGA@Icaritin, which can effectively active ICD and facilitate tumor recruitment in GC through inducing mitoDNA oxidative damage.
Additional file 2: of Effects of Asymmetric Local Joule Heating on Silicon Nanowire-Based Devices Formed by Dielectrophoresis Alignment Across Pt Electrodes
Creators: name: Hsiang-Hsi Ho
name: Chun-Lung Lin
name: Wei-Che Tsai
name: Liang-Zheng Hong
name: Cheng-Han Lyu
name: Hsun-Feng Hsu
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Plant Biology
subject: FOS: Biological sciences

description: Figure S2. Electrical properties of the parallel Si NWs across Pt electrodes in reducing atmosphere (H2/Ar). (PDF 219Â kb)
Old and new approaches to the Sorites paradox
Creators: name: Dinis, Bruno
Publisher: name: arXiv
Year: 2017
Subjects: subject: History and Overview (math.HO)
subject: Logic (math.LO)
subject: FOS: Mathematics

description: The Sorites paradox is the name of a class of paradoxes that arise when vague predicates are considered. Vague predicates lack sharp boundaries in extension and is therefore not clear exactly when such predicates apply. Several approaches to this class of paradoxes have been made since its first formulation by Eubulides of Miletus in the IV century BCE. In this paper I survey some of these approaches and point out some of the criticism that these approaches have received. A new approach that uses tools from nonstandard analysis to model the paradox is proposed.
description: 17 pages
Additional file 1 of Changes in gene body methylation do not correlate with changes in gene expression in Anthozoa or Hexapoda
Creators: name: Dixon, Groves
name: Matz, Mikhail
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Table S1: Reference genomes used in this study.
Additional file 3: Table S2. of Emergency department hyperoxia is associated with increased mortality in mechanically ventilated patients: a cohort study
Creators: name: Page, David
name: Enyo Ablordeppey
name: Wessman, Brian
name: Mohr, Nicholas
name: Trzeciak, Stephen
name: Kollef, Marin
name: Roberts, Brian
name: Fuller, Brian
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: Multivariable logistic regression model with in-hospital mortality as the dependent variable. (DOCX 15 kb)
MPEC 2024-U188 : 2022 UV21
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Statistical link between the structure of molecular clouds and their density distribution
Creators: name: Donkov, Sava
name: Veltchev, Todor V.
name: Klessen, Ralf S.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We introduce the concept of a class of equivalence of molecular clouds represented by an abstract spherically symmetric, isotropic object. This object is described by use of abstract scales in respect to a given mass density distribution. Mass and average density are ascribed to each scale and thus are linked to the density distribution: a power-law type and an arbitrary continuous one. In the latter case, we derive a differential relationship between the mean density at a given scale and the structure parameter which defines the mass-density relationship. The two-dimensional (2D) projection of the cloud along the line of sight is also investigated. Scaling relations of mass and mean density are derived in the considered cases of power-law and arbitrary continuous distributions. We obtain relations between scaling exponents in the 2D and 3D cases. The proposed classes of equivalence are representative for the general structure of real clouds with various types of column-density distributions: power law, lognormal or combination of both.
description: 8 pages, 1 figure; accepted for publication in MNRAS
Interlayer exciton dynamics in a dichalcogenide monolayer heterostructure
Creators: name: Nagler, Philipp
name: Plechinger, Gerd
name: Ballottin, Mariana V.
name: Mitioglu, Anatolie
name: Meier, Sebastian
name: Paradiso, Nicola
name: Strunk, Christoph
name: Chernikov, Alexey
name: Christianen, Peter C. M.
name: Schüller, Christian
name: Korn, Tobias
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: In heterostructures consisting of different transition-metal dichalcogenide monolayers, a staggered band alignment can occur, leading to rapid charge separation of optically generated electron-hole pairs into opposite monolayers. These spatially separated electron-hole pairs are Coulomb-coupled and form interlayer excitons. Here, we study these interlayer excitons in a heterostructure consisting of MoSe$_2$ and WSe$_2$ monolayers using photoluminescence spectroscopy. We observe a non-trivial temperature dependence of the linewidth and the peak energy of the interlayer exciton, including an unusually strong initial redshift of the transition with temperature, as well as a pronounced blueshift of the emission energy with increasing excitation power. By combining these observations with time-resolved photoluminescence measurements, we are able to explain the observed behavior as a combination of interlayer exciton diffusion and dipolar, repulsive exciton-exciton interaction.
Additional file 1 of Hearing loss and depressive symptoms in older Chinese: whether social isolation plays a role
Creators: name: Huang, Hao
name: Wang, Jiao
name: Jiang, Chao Qiang
name: Zhu, Feng
name: Jin, Ya Li
name: Zhu, Tong
name: Zhang, Wei Sen
name: Xu, Lin
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Mental Health

description: Additional file 1: Supplementary Table 1. The four types of social isolation question and thescoring criteria for the composite social isolation score. Supplementary Table2. The Chinese version of four types of social isolation question and thescoring criteria for the composite social isolation score. Supplementary Table3. Associationof hearing loss with depressive symptoms (GDS-15 score ≥8). Supplementary Table4. Association of hearingloss with depressive symptoms after excluding participants with hearing aids (n=20).
title: ADCO, Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Cart. 32 (G 136), 745 folios, f. 1226
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédéric
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 1226, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 1226, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Additional file 1 of Sex-based differences in left ventricular remodeling in patients with chronic aortic regurgitation: a multi-modality study
Creators: name: Tower-Rader, Albree
name: Mathias, Isadora Sande
name: Obuchowski, Nancy A.
name: Kocyigit, Duygu
name: Kumar, Yash
name: Donnellan, Eoin
name: Bolen, Michael
name: Phelan, Dermot
name: Flamm, Scott
name: Griffin, Brian
name: Cho, Leslie
name: Svensson, Lars G.
name: Pettersson, Gosta
name: Popovic, Zoran
name: Kwon, Deborah
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 1: Table S1. Echocardiographic and CMR Data Indexed by BSA and Stratified Based on Aortic Valve Morphology Table S2. Echocardiographic and CMR Data Indexed by Height and Stratified Based on Aortic Valve Morphology
Bars as seen by Herschel & Sloan
Creators: name: Consolandi, Guido
name: Dotti, Massimo
name: Boselli, Alessandro
name: Gavazzi, Giuseppe
name: Gargiulo, Fabio
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present an observational study of the effect of bars on the gas component and on the star formation properties of their host galaxies in a statistically significant sample of resolved objects, the $Herschel$ Reference Sample. The analysis of optical and far--infrared images allows us to identify a clear spatial correlation between stellar bars and the cold-gas distribution mapped by the warm dust emission. We find that the infrared counterparts of optically identified bars are either bar--like structures or dead central regions in which star formation is strongly suppressed. Similar morphologies are found in the distribution of star formation directly traced by H$α$ maps. The sizes of such optical and infrared structures correlate remarkably well, hinting at a causal connection. In the light of previous observations and of theoretical investigations in the literature, we interpret our findings as further evidence of the scenario in which bars drive strong inflows toward their host nuclei: young bars are still in the process of perturbing the gas and star formation clearly delineates the shape of the bars; old bars on the contrary already removed any gas within their extents, carving a dead region of negligible star formation.
description: Accepted for publication in Astronomy and Astrophysics
Anti-photoaging effects of flexible nanoliposomes encapsulated Moringa oleifera Lam. isothiocyanate in UVB-induced cell damage in HaCaT cells
Creators: name: Wang, Yijin
name: Ouyang, Qianqian
name: Chang, Xuefei
name: Yang, Min
name: He, Junpeng
name: Tian, Yang
name: Sheng, Jun
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Skin photoaging is premature skin aging damage that occurs after repeated exposure to ultraviolet (UV) radiation. Although isothiocyanates extracted from the moringa tree (Moringa oleifera Lam.) (MITC) exhibit excellent effects against skin photoaging, its application is restricted because of its characteristics, such as extremely low water solubility, bioavailability, and easy degradation. Currently, flexible nanoliposomes have gained increasing interest as a biocompatible polymer for applications such as transdermal drug delivery. We prepare amphiphilic hyaluronic acid (HA) conjugated with ceramide (CE) to modify nanoliposomes for MITC (HACE/MITC NPs) delivery. The HACE/MITC nanoparticles (NPs) are prepared and characterized for entrapment efficiency, particle size, polydispersity index, zeta potential, in vitro release, in vivo skin permeation, and in vitro protective effect of photoaging. The zeta potential of MITC NPs and HACE/MITC NPs is −24.46 mV and −24.93 mV, respectively. After modification of HACE, the entrapment efficient of MITC liposome increased from 62.54% to 70.67%, and the particle size decreased from 266.1 nm to 192.8 nm. In vivo skin permeation, permeated drug increased from 49.42 to 71.40%. Moreover, the results showed that the entrapment of MITC in nanoliposomes improves its stability, efficacy, and skin permeation. Further, HACE/MITC NPs are favorable for uptake by HaCaT cells without requiring changes in cell morphology, which significantly improves the activities of antioxidant enzymes, scavenges UVB-induced reactive oxygen species, protects skin from damage, and reduces MMP-1, MMP-3, and MMP-9 expression caused by radiation-induced photoaging. Our results strongly suggest that flexible nanoliposomes successfully improved the cell membrane permeation of MITC, and that anti-photoaging and HACE/MITC NPs can potentially be used as candidates for photoaging therapy.
Additional file 1: of Getting messier with TIDieR: embracing context and complexity in intervention reporting
Creators: name: Cotterill, Sarah
name: Knowles, Sarah
name: Martindale, Anne-Marie
name: Elvey, Rebecca
name: Howard, Susan
name: Coupe, Nia
name: Wilson, Paul
name: Spence, Michael
Publisher: name: figshare
Year: 2018
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology

description: Appendix 1: Completed TIDieR templates. (DOCX 58Â kb)
Atmospheric Retrieval for Direct Imaging Spectroscopy of Gas Giants In Reflected Light II: Orbital Phase and Planetary Radius
Creators: name: Nayak, Michael
name: Lupu, Roxana
name: Marley, Mark
name: Fortney, Jonathan
name: Robinson, Tyler
name: Lewis, Nikole
Publisher: name: arXiv
Year: 2016
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Future space-based telescopes, such as the Wide-Field Infrared Survey Telescope (WFIRST), will observe the reflected-light spectra of directly imaged extrasolar planets. Interpretation of such data presents a number of novel challenges, including accounting for unknown planet radius and uncertain stellar illumination phase angle. Here we report on our continued development of Markov Chain Monte Carlo retrieval methods for addressing these issues in the interpretation of such data. Specifically we explore how the unknown planet radius and potentially poorly known observer-planet-star phase angle impacts retrievals of parameters of interest such as atmospheric methane abundance, cloud properties and surface gravity. As expected, the uncertainty in retrieved values is a strong function of signal-to-noise ratio (SNR) of the observed spectra, particularly for low metallicity atmospheres, which lack deep absorption signatures. Meaningful results may only be possible above certain SNR thresholds; for cases across a metallicity range of 1-50 times solar, we find that only an SNR of 20 systematically reproduces close to the correct methane abundance at all phase angles. However, even in cases where the phase angle is poorly known we find that the planet radius can be constrained to within a factor of two. We find that uncertainty in planet radius decreases at phase angles past quadrature, as the highly forward scattering nature of the atmosphere at these geometries limits the possible volume of phase space that relevant parameters can occupy. Finally, we present an estimation of possible improvement that can result from combining retrievals against observations at multiple phase angles.
description: Accepted to PASP
title: Rouelle (Inv. 2004.32.1192.1)
Creators: name: Aitchison, Kenneth
name: -
name: -
name: -
Publisher: name: Conservatoire National des Données 3D (CND3D)
Year: 2024
Subjects: subject: parure
subject: Artefact
subject: ACQUISITION

description: Modèle 3D
Navier-Stokes flow past a rigid body: attainability of steady solutions as limits of unsteady weak solutions, starting and landing cases
Creators: name: Hishida, Toshiaki
name: Maremonti, Paolo
Publisher: name: arXiv
Year: 2017
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35Q30, 76D05

description: Consider the Navier-Stokes flow in 3-dimensional exterior domains, where a rigid body is translating with prescribed translational velocity $-h(t)u_\infty$ with constant vector $u_\infty\in \mathbb R^3\setminus\{0\}$. Finn raised the question whether his steady slutions are attainable as limits for $t\to\infty$ of unsteady solutions starting from motionless state when $h(t)=1$ after some finite time and $h(0)=0$ (starting problem). This was affirmatively solved by Galdi, Heywood and Shibata for small $u_\infty$. We study some generalized situation in which unsteady solutions start from large motions being in $L^3$. We then conclude that the steady solutions for small $u_\infty$ are still attainable as limits of evolution of those fluid motions which are found as a sort of weak solutions. The opposite situation, in which $h(t)=0$ after some finite time and $h(0)=1$ (landing problem), is also discussed. In this latter case, the rest state is attainable no matter how large $u_\infty$ is.
The color-magnitude distribution of Hilda asteroids: Comparison with Jupiter Trojans
Creators: name: Wong, Ian
name: Brown, Michael E.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Current models of Solar System evolution posit that the asteroid populations in resonance with Jupiter are comprised of objects scattered inward from the outer Solar System during a period of dynamical instability. In this paper, we present a new analysis of the absolute magnitude and optical color distribution of Hilda asteroids, which lie in the 3:2 mean motion resonance with Jupiter, with the goal of comparing the bulk properties with previously published results from an analogous study of Jupiter Trojans. We report an updated power law fit of the Hilda magnitude distribution through H=14. Using photometric data listed in the Sloan Moving Object Catalog, we confirm the previously-reported strong bimodality in visible spectral slope distribution, indicative of two sub-populations with differing surface compositions. When considering collisional families separately, we find that collisional fragments follow a unimodal color distribution with spectral slope values consistent with the bluer of the two sub-populations. The color distributions of Hildas and Trojans are comparable and consistent with a scenario in which the color bimodality in both populations developed prior to emplacement into their present-day locations. We propose that the shallower magnitude distribution of the Hildas is a result of an initially much larger Hilda population, which was subsequently depleted as smaller bodies were preferentially ejected from the narrow 3:2 resonance via collisions. Altogether, these observations provide a strong case supporting a common origin for Hildas and Trojans as predicted by current dynamical instability theories of Solar System evolution.
description: 7 pages, 6 figures, accepted for publication in AJ