cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Association between oestrogen receptors and female temporomandibular disorders
Creators: name: Küchler, Erika Calvano
name: Meger, Michelle Nascimento
name: Omori, Marjorie Ayumi
name: Gerber, Jennifer Tsi
name: Neto, Evandro Carneiro Martins
name: Nilza Cristina Da Silva Machado
name: Cavalcante, Rafael Corrêa
name: Teixeira, Lucas Ribeiro
name: Stuani, Maria Bernadete
name: Filho, Paulo Nelson
name: Delson João Da Costa
name: Souza, Juliana Feltrin De
name: Brancher, João Armando
name: León, Jorge Esquiche
name: Scariot, Rafaela
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objective: To evaluate if temporomandibular disorders (TMDs) are associated with genetic polymorphisms in ESR1 and ESR2, which are genes encoding oestrogen receptor alpha (ERα) and beta (ERβ). Also, we included an animal model to check if ERα and ERβ are expressed in the temporomandibular joint (TMJ) during adolescence. Materials and methods: A total of 139 teenagers and 93 adults were diagnosed according to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMDs). The DNA was collected and the markers ESR1 and ERS2 were genotyped. Additionally, immunohistochemistry was performed in TMJ tissues from female Wistar rats during puberty. All data were submitted to statistical analysis with confidence interval of 95%. Results: Teenagers presented more disc displacement and arthralgia than adults (p rs1256049 in ESR2 was associated with disc displacement (p = .040; OR = 10.50/95%CI 1.17–98.74) and arthralgia (p = .036; OR = 7.20/95%CI 1.10–46.88) in adults. The ERα and ERβ are expressed in rat TMJ tissues. Conclusions: We provide evidence that ESR2 is associated with TMD and could be a genetic marker for this condition in adult women. Furthermore, oestrogens receptors are presented in TMJ of adolescent female rats.
Stiff polymer in monomer ensemble
Creators: name: Muller-Nedebock, K. K.
name: Frisch, H. L.
name: Percus, J. K.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We make use of the previously developed formalism for a monomer ensemble and include angular dependence of the segments of the polymer chains thus described. In particular we show how to deal with stiffness when the polymer chain is confined to certain regions. We investigate the stiffness from the perspectives of a differential equation, integral equations, or recursive relations for both continuum and lattice models. Exact analytical solutions are presented for two cases, whereas numerical results are shown for a third case.
description: 10 pages, including 6 figures
Data of strain analysis in MEMIN A37 and A38.xlsx
Creators: name: Agarwal, Amar
name: Kenkmann, Thomas
name: Poelchau, Michael
Publisher: name: figshare
Year: 2019
Subjects: subject: 40312 Structural Geology
subject: FOS: Earth and related environmental sciences
subject: Planetary Geology

description: The data is linked to a paper in JGR:solid earth titled Impact experiment on gneiss: The effects of foliation on cratering process
The Role of Affectionate Caregiver Touch in Early Neurodevelopment and Parent–Infant Interactional Synchrony
Creators: name: Carozza, Sofia
name: Leong, Victoria
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Neuroscience
touch
synchrony
social interaction
oxytocin
neurodevelopment
parent–infant

description: Though rarely included in studies of parent–infant interactions, affectionate touch plays a unique and vital role in infant development. Previous studies in human and rodent models have established that early and consistent affectionate touch from a caregiver confers wide-ranging and holistic benefits for infant psychosocial and neurophysiological development. We begin with an introduction to the neurophysiological pathways for the positive effects of touch. Then, we provide a brief review of how affectionate touch tunes the development of infant somatosensory, autonomic (stress regulation), and immune systems. Affective touch also plays a foundational role in the establishment of social affiliative bonds and early psychosocial behavior. These touch-related bonding effects are known to be mediated primarily by the oxytocin system, but touch also activates mesocorticolimbic dopamine and endogenous opioid systems which aid the development of social cognitive processes such as social learning and reward processing. We conclude by proposing a unique role for affectionate touch as an essential pathway to establishing and maintaining parent-infant interactional synchrony at behavioral and neural levels. The limitations of the current understanding of affectionate touch in infant development point to fruitful avenues for future research.
title: Основы судебного и общественно-политического красноречия
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2021

description: Издание включает в себя выдержки из теоретических работ по основам красноречия и тексты речей выдающихся судебных и общественно-политических ораторов разных исторических периодов, а также дидактические материалы для развития дикции, формирования логического мышления и навыков публичного выступления. Хрестоматия будет полезна студентам укрупненной группы специальностей и направлений подготовки 40.00.00 «Юриспруденция» при изучении дисциплин «Юридическая риторика», «Профессиональная риторика для юристов», «Риторика для юристов», «Риторика и судебная речь», «Судебная речь», а также при освоении курсов «Риторика», «Политическая риторика» по укрупненной группе 41.00.00 «Политические науки и регионоведение». Издание может быть использовано на курсах повышения квалификации для специалистов, деятельность которых связана с публичными выступлениями.
The placenta protects the fetal circulation from anxiety-driven elevations in maternal serum levels of brain-derived neurotrophic factor
Creators: name: Dingsdale, Hayley
name: Nan, Xinsheng
name: Garay, Samantha M.
name: Mueller, Annett
name: Sumption, Lorna A.
name: Chacón-Fernández, Pedro
name: Martinez-Garay, Isabel
name: Ghevaert, Cedric
name: Barde, Yves-Alain
name: John, Rosalind M.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Article
/692/699/476/1414
/631/477
/64/60
/82/80
/38/1
/38
/64
article

description: Funder: European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie Grant Agreement 663830
description: Funder: Welsh Government’s Sêr Cymru programme
description: Funder: NHS Blood and Transplant
description: Abstract: Brain-derived neurotrophic factor (BDNF) plays crucial roles in brain function. Numerous studies report alterations in BDNF levels in human serum in various neurological conditions, including mood disorders such as depression. However, little is known about BDNF levels in the blood during pregnancy. We asked whether maternal depression and/or anxiety during pregnancy were associated with altered serum BDNF levels in mothers (n = 251) and their new-born infants (n = 212). As prenatal exposure to maternal mood disorders significantly increases the risk of neurological conditions in later life, we also examined the possibility of placental BDNF transfer by developing a new mouse model. We found no association between maternal symptoms of depression and either maternal or infant cord blood serum BDNF. However, maternal symptoms of anxiety correlated with significantly raised maternal serum BDNF exclusively in mothers of boys (r = 0.281; P = 0.005; n = 99). Serum BDNF was significantly lower in male infants than female infants but neither correlated with maternal anxiety symptoms. Consistent with this observation, we found no evidence for BDNF transfer across the placenta. We conclude that the placenta protects the developing fetus from maternal changes in serum BDNF that could otherwise have adverse consequences for fetal development.
Oscillations of a solid sphere falling through a wormlike micellar fluid
Creators: name: Jayaraman, Anandhan
name: Belmonte, Andrew
Publisher: name: arXiv
Year: 2002
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We present an experimental study of the motion of a solid sphere falling through a wormlike micellar fluid. While smaller or lighter spheres quickly reach a terminal velocity, larger or heavier spheres are found to oscillate in the direction of their falling motion. The onset of this instability correlates with a critical value of the velocity gradient scale $Γ_{c}\sim 1$ s$^{-1}$. We relate this condition to the known complex rheology of wormlike micellar fluids, and suggest that the unsteady motion of the sphere is caused by the formation and breaking of flow-induced structures.
description: 4 pages, 4 figures
Willingness to Pay for Crop Insurance Premium-A Study on Maize Farmers in India
Creators: name: Kiran, Shashi
name: Umesh, K.B.
name: Kiran, Shashi
name: Umesh, K.B.
Publisher: name: Unknown
Year: 2015
Subjects: subject: Agricultural Finance
subject: Crop Production/Industries
subject: Risk
subject: Crop insurance
subject: Premium
subject: Willingness to pay

description: Agricultural activity is subject to a wide range of risks due to the variable economic and biophysical environment in which farming operates. Agriculture risks arise due to uncertainty over factors determining returns to agricultural production. Crop insurance is one of the risk mitigating strategies for farmers. The objective of the study was to estimate WTP by the rainfed maize farmres to crop insurance premium and also factors influencing their WTP. The study revealed that farmers were willing to pay 0.34 percent more premium than the prevailing rate to insure their crop. The average probability of WTP of farmers for crop insurance premium was 0.53. Age was the important factor influencing their WTP. It was observed that farmers' awareness about the products and procedures of crop insurance was poor. Hence, efforts should be made to increase the awareness and help farmers to take advantage of crop insurance.
Childhood Shocks, Safety nets and Cognitive Skills: Panel Data Evidence from Rural Ethiopia
Creators: name: Berhane, Guush
name: Abay, Mehari
name: Woldehanna, Tassew
name: Berhane, Guush
name: Abay, Mehari
name: Woldehanna, Tassew
Publisher: name: Unknown
Year: 2015
Subjects: subject: Labor and Human Capital
subject: Risk and Uncertainty
subject: Shock
subject: safety nets
subject: cognitive skill
subject: children
subject: Ethiopia

description: A growing body of evidence emphasizes that shocks in early childhood can have irreversible effects on long-term child welfare and poverty. However, evidence on effects of shocks in early childhood on child cognition, particularly when measured after early childhood window during preschool and beyond, is scarce. Using child-level panel data from rural areas of Ethiopia, this paper analyzes effects of both economic and non-economic shocks on child cognition skills measured after early childhood age window. We find that exposure to these shocks significantly decreased child cognitive skills. On the other hand, safety net program put in place in 2005 to protect households from the economic effects of such shocks mitigated the reduction in cognitive skills. Results suggest that social safety nets, if well designed and implemented, can help check the long-lasting detrimental effects of shocks experienced during early childhood. This is crucial for child welfare and future human capital development.
Information paradox and corrected thermodynamics for black holes
Creators: name: Zhang, Ming
Publisher: name: arXiv
Year: 2019
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We generally consider that entropy and temperature of a spherically symmetric black hole are corrected by quantum effect. We calculate interior entropy variation of massless scalar field and compare it with corrected Bekenstein-Hawking entropy variation for the evaporating black hole. We find that the corrected ratio between them is greater than the uncorrected one. The information paradox is then discussed.
description: 7 pages
The Role of the Internal Auditor in Preventing Fraud and Errors in Nigerian Firms
Creators: name: Ndukwu, Valentine
Publisher: name: figshare
Year: 2019
Subjects: subject: 150102 Auditing and Accountability
subject: FOS: Economics and business

description: This study examines the role of the internal auditor in preventing fraud and errors in Nigerian firms. Data used for the study were obtained from both primary and secondary source. Questionnaires were issued to 41 staff of UBA Plc and 48 staff of First Bank Plc, Calabar branch. Secondary source of data were obtained through the Nigerian Deposit Insurance Corporation (NDIC) annual reports, journals, textbooks, and online materials. Responses were selected using Random Sampling technique. Responses were tested using Pearson chi-square test of goodness-of-fit. Some existing literature on fraud were reviewed and recommendations based on the findings were highlighted. It was observed that staffs got involve in the increasing number of fraudulent and erroneous activities in the banking sector due to the lack of integrity, competence, and independence of the internal auditor in the discharge of his duties.
Social Networks and Factor Markets: Panel Data Evidence from Ethiopia
Creators: name: Abay, Kibrom
name: Kahsay, Goytom
name: Berhane, Guush
name: Abay, Kibrom
name: Kahsay, Goytom
name: Berhane, Guush
Publisher: name: Unknown
Year: 2015
Subjects: subject: Marketing
subject: FOS: Economics and business
subject: Public Economics
subject: Social networks
subject: iddir networks
subject: factor market imperfections
subject: factor market transactions
subject: crowding-out

description: In the absence of well-established factor markets, the role of indigenous institutions and social networks can be substantial for mobilizing factors for agricultural production. We investigate the role of an indigenous social network in Ethiopia, the iddir, in facilitating factor market transactions among smallholder farmers. Using detailed longitudinal household survey data and employing a difference-in-differences approach, we find that iddir membership improves households’ access to factor markets. Specifically, we find that joining an iddir network improves households’ access to land, labor and credit transactions between 7 and 11 percentage points. Furthermore, our findings also indicate that iddir networks crowd-out borrowing from local moneylenders (locally referred as Arata Abedari), a relatively expensive credit source, virtually without affecting borrowing from formal credit sources. These results point out the roles non-market arrangements, such as social networks, can play in mitigating market inefficiencies in poor rural markets.
Ranatra (Ranatra) linearis ET AT
Creators: name: Fent, Meral
name: Kment, Petr
name: Çamur-Elipek, Belgin
name: Kirgiz, Timur
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Nepidae
Ranatra
Ranatra linearis

description: Ranatra (Ranatra) linearis (Linnaeus, 1758)
 Material examined. EUROPEAN TURKEY: Edirne province: Süleoğlu (loc. 8), 1 ♀; Enez—Gala Gölü [lake] (loc. 10), 1 ♀; Güllapoğlu Deresi [stream] (loc. 11), 1 ♀, M. Fent det. (TUET). Kırklareli province: Babaeski— Lahana village (loc. 9), 3 ♂♂ 1 ♀, M. Fent det. (TUET). İstanbul province: Büyükçekmece (Tepecik) Gölü [lake] (loc. 25), 1 ♀, M. Fent det. (TUET).
 European Turkey. Josifov (1986a), Polhemus (1995a), Aukema (2009); this paper. First exact records from Turkish Thrace.
 Asian Turkey. Lindberg (1922b), Hoberlandt (1952a, revised!), Özesmi & Önder (1988), Polhemus (1995a), Bat et al. (2000), Kıyak et al. (2004), Önder et al. (2006), Kıyak et al. (2007a), Topkara et al. (2009), Dursun (2011).
 Turkey (not distinguished). Stichel (1955), Nieser & Moubayed (1985), Kıyak & Özsaraç (2001).
 General distribution. Palaearctic Region, reaching from Great Britain and Morocco to Iran, Central Asia, northwestern China (Xinjiang), and East Siberia (east to Altai Mts. and Yenisey river) (Polhemus 1995 a, Protić 1998, Linnavuori & Hosseini 2000, Chen et al. 2004, Coulianos 2005, Kanyukova 2006).
 Identification. Stichel (1955), Poisson (1957), Nieser (1972), Tamanini (1979), Kanyukova (1989, 2006), Nieser et al. (1994), Linnavuori & Hosseini (2000).
description: Published as part of Fent, Meral, Kment, Petr, Çamur-Elipek, Belgin & Kirgiz, Timur, 2011, Annotated catalogue of Enicocephalomorpha, Dipsocoromorpha, Nepomorpha, Gerromorpha, and Leptopodomorpha (Hemiptera: Heteroptera) of Turkey, with new records 2856, pp. 1-84 in Zootaxa 2856 (1) on page 11, DOI: 10.11646/zootaxa.2856.1.1, http://zenodo.org/record/5286719
Detection of Genuine Multipartite Entanglement in Multipartite Systems
Creators: name: Zhao, Jing Yun
name: Zhao, Hui
name: Jing, Naihuan
name: Fei, Shao-Ming
Publisher: name: arXiv
Year: 2019
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We investigate genuine multipartite entanglement in general multipartite systems. Based on the norms of the correlation tensors of a multipartite state under various partitions, we present an analytical sufficient criterion for detecting the genuine four-partite entanglement. The results are generalized to arbitrary multipartite systems.
Significance of the physician’s and the patient’s sex in hospitalized patients with community-acquired pneumonia
Creators: name: Dwyer, Richard
name: Kalin, Mats
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Numerous studies have revealed that the sex of the patient or of the attending physician have impact on patient care, treatment, morbidity and mortality. Community-acquired pneumonia (CAP) is a common cause of hospitalization, antibiotic treatment and intensive care unit (ICU) admission. The purpose of this study was to examine if the patient’s or the attending physicians’ sex may influence the management of hospitalized patients with CAP. Our study included 826 consecutive inpatients with CAP (404 females, and 422 male patients, 429 patients initially treated by a female physician and 397 patients initially treated by a male physician). We examined if the patient’s, or the initial attending physician’s sex, affected treatment and outcome in patients with CAP. Patients mean age was 69 years, 30-day mortality 9%. By use of the pneumonia severity index, male patients were found to be more severely ill at admission (p = .0008). Fewer female physicians’ patients were admitted from the emergency department (ED) to the ICU when compared to male physicians’ patients, 5% versus 10% (p = .006), and female physicians’ patients received their first intravenous (IV) antibiotic dose later than male physicians’ patients in the ED (p = .003). Our study indicates that the sex of the attending physician may affect the chosen level of care and antibiotic treatment, and that admitted male patients with CAP were more seriously ill than admitted female patients with CAP.
Two-dimensional projections of an hypercube
Creators: name: Abramson, Guillermo
name: Zanette, Damian H.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: We present a method to project a hypercube of arbitrary dimension on the plane, in such a way as to preserve, as well as possible, the distribution of distances between vertices. The method relies on a Montecarlo optimization procedure that minimizes the squared difference between distances in the plane and in the hypercube, appropriately weighted. The plane projections provide a convenient way of visualization for dynamical processes taking place on the hypercube.
description: 4 pages, 3 figures, Revtex 4
The Policy Analysis Matrix of Profitability and Competitiveness of Rice Farming in Malaysia
Creators: name: Fazleen, Abdul
name: Stephan, Von Cramon
name: Fazleen, Abdul
name: Stephan, Von Cramon
Publisher: name: Unknown
Year: 2015
Subjects: subject: Agribusiness
subject: Agricultural and Food Policy
subject: Crop Production/Industries
subject: policy analysis matrix
subject: comparative advantage
subject: rice production
subject: Malaysia

description: In recent years, the Malaysian rice sector has experienced structural changes to increase its competitiveness within a dynamic environment that is influenced by political, technical, economic and international trade challenges. Using a Policy Analysis Matrix, this paper examines whether Malaysia would have the comparative advantage in rice production under different scenarios of existing policies and economic reforms. The empirical results show that the rice farming is marginally competitive and generates relatively low social profits. Other empirical results show that three out of four states have comparative advantages in producing rice with Domestic Resource Cost values or DRCs less than one. Conversely, the results indicate no comparative advantage for rice production in the KETARA granary area, as DRC is greater than one.
Data of strain analysis in MEMIN A37 and A38.xlsx
Creators: name: Agarwal, Amar
Publisher: name: figshare
Year: 2019
Subjects: subject: 40312 Structural Geology
subject: FOS: Earth and related environmental sciences
subject: Planetary Geology

description: The data is linked to a paper in JGR:solid earth titled Impact experiment on gneiss: The effects of foliation on cratering process
Impact of Improved cassava varieties' adoption on farmers' incomes in Rural Ghana
Creators: name: Acheampong, Patricia
name: Owusu, Victor
name: Acheampong, Patricia
name: Owusu, Victor
Publisher: name: Unknown
Year: 2015
Subjects: subject: Consumer/Household Economics
subject: Crop Production/Industries
subject: Improved cassava variety
subject: impact
subject: income
subject: women
subject: propensity score matching
subject: Ghana

description: Using data from 450 cassava farmers from three districts, the paper uses a non-parametric propensity score matching (PSM) technique to investigate the impact on men and women farmers’ incomes by adopting improved cassava varieties. The Average treatment effect (ATT) estimates suggested that participation in improved cassava varieties increased total crop incomes of women by ₵3173 (USD 1823) whilst that of men was increased by ₵149 (USD 86) per hectare. The findings offer justification for sustained public investment in cassava research and dissemination in Ghana.
HIV infection and multidrug resistant tuberculosis: a systematic review and meta-analysis
Creators: name: Sultana, Zeeba Zahra
name: Hoque, Farhana Ul
name: Beyene, Joseph
name: Akhlak-Ul-Islam, Md.
name: Khan, Md Hasinur Rahman
name: Ahmed, Shakil
name: Hawlader, Delwer Hossain
name: Hossain, Ahmed
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Research Article
HIV and co-infections
Multidrug resistant
Drug-resistant
Tuberculosis
MDR-TB
HIV
Meta-analysis

description: Funder: North South University Internal Research Grant
description: Abstract: Background: Multidrug-resistant tuberculosis (MDR-TB) in HIV infected individuals is a serious threat to global efforts to combat tuberculosis. Inconsistent findings on the association between HIV infection and MDR-TB were present in many studies. We aimed to review existing data on the relationship between HIV infection and MDR-TB systematically to assess the contribution of HIV on MDR-TB worldwide. We also investigated the patterns of MDR-TB by age, country-wise income, study designs, and global regions. Methods: We utilized PubMed, Google Scholar, and ScienceDirect databases to select eligible studies for meta-analysis that were published between January 1, 2010, and July 30, 2020. The random-effects model was used to obtain the pooled odds ratio of the crude association between HIV and MDR-TB with a 95% confidence interval. We investigated the potential publication-bias by checking funnel plot asymmetry and using the Egger’s test. Moreover, we assessed the heterogeneity using the I2 statistic. Sensitivity analysis was performed based on sample size and adjustment factors. The protocol was registered with PROSPERO-CRD42019132752. Results: We identified 1603 studies through a database search, and after subsequent eliminations we selected 54 studies including 430,534 TB patients. The pooled odds of MDR-TB was 1.42 times higher in HIV-positive patients than HIV-negative patients (OR=1.42,CI=1.17–1.71, I2=75.8%). Subgroup analysis revealed that the estimated pooled odds for South-East Asian countries was 1.86, which is the highest in WHO regions (OR=1.86,CI=1.30–2.67, I2=0.00%), followed by Europe and Africa. The effect estimate was found to be higher for primary MDR-TB (OR=2.76,CI=1.70–4.46, I2=0.00%). There was also a trend towards increased odds of MDR-TB for HIV patients older than 40 years (OR=1.56,CI=1.17–2.06). The association was found to be significant in high-burden TB countries (OR=1.75, CI=1.39–2.19) and in high-income countries (OR=1.55, CI=1.06–2.27). Conclusion: Such findings indicate that HIV infection raises the risk of MDR-TB, and after contrasting it with the results of the earlier pooled study, it appeared to be an upward risk trend. Moreover, we found that the risk is the highest in the South-East Asian region. A balanced allocation of resources is needed to halt both primary and secondary MDR-TB, particularly in HIV infected people with 40 years of age and older.
Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure
Creators: name: Liu, Anika
name: Walter, Moritz
name: Wright, Peter
name: Bartosik, Aleksandra
name: Dolciami, Daniela
name: Elbasir, Abdurrahman
name: Yang, Hongbin
name: Bender, Andreas
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: subject: Research
subject: Bioinformatics
subject: FOS: Computer and information sciences
subject: Proceedings of the Critical Assessment of Massive Data Analysis (CAMDA) Satellite Meeting to ISMB 2019
subject: Drug-induced liver injury (DILI)
subject: Mechanistic models
subject: Structural alerts
subject: Protein target

description: Funder: GlaxoSmithKline (GB)
description: Abstract: Background: Drug-induced liver injury (DILI) is a major safety concern characterized by a complex and diverse pathogenesis. In order to identify DILI early in drug development, a better understanding of the injury and models with better predictivity are urgently needed. One approach in this regard are in silico models which aim at predicting the risk of DILI based on the compound structure. However, these models do not yet show sufficient predictive performance or interpretability to be useful for decision making by themselves, the former partially stemming from the underlying problem of labeling the in vivo DILI risk of compounds in a meaningful way for generating machine learning models. Results: As part of the Critical Assessment of Massive Data Analysis (CAMDA) “CMap Drug Safety Challenge” 2019 (http://camda2019.bioinf.jku.at), chemical structure-based models were generated using the binarized DILIrank annotations. Support Vector Machine (SVM) and Random Forest (RF) classifiers showed comparable performance to previously published models with a mean balanced accuracy over models generated using 5-fold LOCO-CV inside a 10-fold training scheme of 0.759 ± 0.027 when predicting an external test set. In the models which used predicted protein targets as compound descriptors, we identified the most information-rich proteins which agreed with the mechanisms of action and toxicity of nonsteroidal anti-inflammatory drugs (NSAIDs), one of the most important drug classes causing DILI, stress response via TP53 and biotransformation. In addition, we identified multiple proteins involved in xenobiotic metabolism which could be novel DILI-related off-targets, such as CLK1 and DYRK2. Moreover, we derived potential structural alerts for DILI with high precision, including furan and hydrazine derivatives; however, all derived alerts were present in approved drugs and were over specific indicating the need to consider quantitative variables such as dose. Conclusion: Using chemical structure-based descriptors such as structural fingerprints and predicted protein targets, DILI prediction models were built with a predictive performance comparable to previous literature. In addition, we derived insights on proteins and pathways statistically (and potentially causally) linked to DILI from these models and inferred new structural alerts related to this adverse endpoint.
Global baryon number conservation encoded in net-proton fluctuations measured in Pb-Pb collisions at $\sqrt{s_{\rm NN}}$ = 2.76 TeV
Creators: name: ALICE Collaboration
Publisher: name: arXiv
Year: 2019
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Experimental results are presented on event-by-event net-proton fluctuation measurements in Pb-Pb collisions at $\sqrt{s_{\rm NN}}$ = 2.76 TeV, recorded by the ALICE detector at the CERN LHC. These measurements have as their ultimate goal an experimental test of Lattice QCD (LQCD) predictions on second and higher order cumulants of net-baryon distributions to search for critical behavior near the QCD phase boundary. Before confronting them with LQCD predictions, account has to be taken of correlations stemming from baryon number conservation as well as fluctuations of participating nucleons. Both effects influence the experimental measurements and are usually not considered in theoretical calculations. For the first time, it is shown that event-by-event baryon number conservation leads to subtle long-range correlations arising from very early interactions in the collisions.
description: 16 pages, 2 captioned figures, authors from page 11, published version, figures at http://alice-publications.web.cern.ch/node/5645
Hubble Space Telescope Evidence for an Intermediate-Mass Black Hole in the Globular Cluster M15: I. STIS Spectroscopy and WFPC2 Photometry
Creators: name: van der Marel, Roeland P.
name: Gerssen, Joris
name: Guhathakurta, Puragra
name: Peterson, Ruth
name: Gebhardt, Karl
Publisher: name: arXiv
Year: 2002
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: In this series of two papers we describe a project with STIS on HST to measure the line-of-sight velocities of stars in the central few arcsec of the dense globular cluster M15. This first paper focuses on the observations and reduction of the data. We `scanned' the central region of M15 spectroscopically by consecutively placing an 0.1 arcsec slit at 18 adjacent positions. Careful and complicated data reduction and analysis were required. The spectral pixel size exceeds the velocity dispersion of M15, which puts the project at the limit of what is feasible with STIS. We applied corrections for the following effects: drifts in the STIS wavelength scale during an HST orbit; the orbital velocity component of HST along the line-of-sight to the cluster, and its variations during the HST orbit; and the apparent wavelength shift that is perceived for a star that is not centered in the slit. To make these corrections we present a detailed study of the HST/STIS point-spread function and line-spread function. We also present a catalog with positions and U, B and V magnitudes of 31,983 stars in M15, created from existing HST/WFPC2 data. We extract 19,200 one-dimensional spectra from the STIS data, each for a different position in M15, and each with a velocity scale accurate to better than 2.5 km/s. We develop an algorithm that co-adds the spectra for individual apertures and use it to extract spectra of individual stars with minimum blending and maximum S/N. In Paper II we use these spectra to extract the line-of-sight velocities of individual stars. The velocities constrain the central structure, dynamics and mass distribution of the cluster, and provide evidence for the existence of an intermediate-mass black hole in the center of the cluster.[ABRIDGED]
description: 38 pages, LaTeX, with 12 PostScript figures. Astronomical Journal, in press (Dec 2002)
Sources of technical inefficiency of smallholder farmers in milk production in Ethiopia
Creators: name: Adane, Zewdie
name: Shiferaw, Kaleb
name: Gebremedhin, Berhanu
name: Adane, Zewdie
name: Shiferaw, Kaleb
name: Gebremedhin, Berhanu
Publisher: name: Unknown
Year: 2015
Subjects: Agribusiness
Agricultural Finance

description: This paper estimates technical inefficiency in milk production of smallholder dairy farmers in the highlands of Ethiopia and identifies factors associated with the observed inefficiency using a stochastic frontier production function approach. The analysis utilizes cross-section data collected from 1277 farmers. The result indicates a mean technical efficiency of 55%, suggesting sizeable technical inefficiency in milk production. The results further show that household wealth, education level and access to markets and institutions are the main drivers of technical efficiency in dairy production. Evidently by improving smallholder access to market and institutions as well as investing on adult education, it is possible to bring considerable gain in milk production.
A transition in the Dutch wastewater system? The struggle between discourses and with lock-ins
Creators: name: Ampe, Kasper
name: Paredis, Erik
name: Asveld, Lotte
name: Osseweijer, Patricia
name: Block, Thomas
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Recently, calls have increased for a paradigm shift or transition towards resource recovery and a circular economy in the Dutch wastewater system. However, we have observed diverging interpretations on the nature of the transition. This reflects the political environment of sustainability transitions: political struggle emerges over the definition of problems, futures and strategies to be used. In order to help clarify the emerging debate and identify political choices, we conducted a discourse analysis. We identified three discourses that reveal some of the political choices to be made. One discourse is becoming dominant and focusses on optimising the large-scale infrastructure, market development and legislative changes. The discourse draws on the existing infrastructure and current political-economic institutions, which gives it an advantage in becoming dominant. Our findings also suggest that this discourse shapes a transition pathway that is characterised by lock-in effects and, at most, incremental changes instead of a fundamental shift in the established Dutch wastewater system.
A Gender Gap in Agricultural Productivity? Evidence from the Dairy Sector in India
Creators: name: Sneyers, Astrid
name: Vandeplas, Anneleen
name: Sneyers, Astrid
name: Vandeplas, Anneleen
Publisher: name: Unknown
Year: 2015
Subjects: subject: Agribusiness
subject: Livestock Production/Industries
subject: agricultural productivity
subject: dairy sector
subject: gender
subject: female decision-making power

description: In agriculture, women have been found to be less productive than men for a variety of reasons. Most of the studies in this domain focus on crop production, and so far there has been little evidence on the impact of gender on productivity in dairy. This paper provides empirical evidence of the impact of female decision-making power on dairy productivity in India, based on a unique household-level dataset collected in 2010 in 50 villages in Andhra Pradesh, a state in the South of India. Our analysis suggests that higher productivity is achieved in households where women take dairy production-related decisions. While caution is due in drawing overly strong conclusions, our results provide a more nuanced view on the impact of gender on agricultural productivity than the one usually put forward in the literature.
Lethocerus Mayr 1853
Creators: name: Fent, Meral
name: Kment, Petr
name: Çamur-Elipek, Belgin
name: Kirgiz, Timur
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Belostomatidae
Lethocerus

description: Lethocerus Mayr, 1853
 Comment. Perez Goodwyn (2006) raised the Nearctic subgenus Benacus Stål, 1861 and resurrected the synonym Kirkaldyia Montandon, 1909, both as valid genera. Therefore, Lethocerus Mayr, 1853 includes now only the nominotypical subgenus.
description: Published as part of Fent, Meral, Kment, Petr, Çamur-Elipek, Belgin & Kirgiz, Timur, 2011, Annotated catalogue of Enicocephalomorpha, Dipsocoromorpha, Nepomorpha, Gerromorpha, and Leptopodomorpha (Hemiptera: Heteroptera) of Turkey, with new records 2856, pp. 1-84 in Zootaxa 2856 (1) on page 12, DOI: 10.11646/zootaxa.2856.1.1, http://zenodo.org/record/5286719
Ochterus (Ochterus) marginatus subsp. marginatus marginatus (Latreille 1804
Creators: name: Fent, Meral
name: Kment, Petr
name: Çamur-Elipek, Belgin
name: Kirgiz, Timur
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Ochteridae
Ochterus
Ochterus marginatus
Ochterus (ochterus) marginatus marginatus (latreille, 1804)

description: Ochterus (Ochterus) marginatus marginatus (Latreille, 1804)
 Material examined. ASIAN TURKEY: Antalya province: 80 km NE of Antalya, BeŞkonak, Köprülü canyon, 7.ix.1992, 2 ♀♀ 1 larva (instar 5), Z. Jindra lgt., P. Kment det. (ZJPC).
 European Turkey. Polhemus (1995c), Aukema (2009).
 Asian Turkey. Horváth (1883, as Pelegonus [sic !] marginatus), Lindberg (1922b), Hoberlandt (1952a, revised!), Linnavuori (1965), Polhemus (1995c), Önder et al. (2006), Kıyak et al. (2007a), Şerban (2010); this paper.
 Turkey (not distinguished). Stichel (1955), Nieser & Moubayed (1985), Önder & Lodos (1988), Kıyak & Özsaraç (2001), Kanyukova (2006).
 General distribution. Southern Europe, northern and tropical Africa, Cyprus, Anatolia, Transcaucasia, Daghestan, Lebanon, Syria, Jordan, Saudia Arabia, the United Arab Emirates, Iran, Afghanistan, Turkmenistan, Afghanistan, China, Taiwan, Korea, Russian Far East (Kunashir Island), Japan, and tropical Asia (Polhemus 1995c, Protić 1998, Katbeh et al. 2000, Kanyukova 2006, Linnavuori et al. 2011).
 Identification. Stichel (1955), Poisson (1957), Nieser (1972), Tamanini (1979), Nieser et al. (1994), Linnavuori & Hosseini (2000), Kanyukova (2006).
description: Published as part of Fent, Meral, Kment, Petr, Çamur-Elipek, Belgin & Kirgiz, Timur, 2011, Annotated catalogue of Enicocephalomorpha, Dipsocoromorpha, Nepomorpha, Gerromorpha, and Leptopodomorpha (Hemiptera: Heteroptera) of Turkey, with new records 2856, pp. 1-84 in Zootaxa 2856 (1) on page 12, DOI: 10.11646/zootaxa.2856.1.1, http://zenodo.org/record/5286719
Evaluating and Comparing Behavioural and Electrophysiological Estimates of Neural Health in Cochlear Implant Users
Creators: name: Brochier, Tim
name: Guérit, François
name: Deeks, John M.
name: Garcia, Charlotte
name: Bance, Manohar
name: Carlyon, Robert P.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Research Article
cochlear implants
neural health
neural survival
ECAP
psychophysics
inter-phase gap
polarity effect
multi-pulse integration
computational modelling

description: Abstract: Variations in neural health along the cochlea can degrade the spectral and temporal representation of sounds conveyed by cochlear implants (CIs). We evaluated and compared one electrophysiological measure and two behavioural measures that have been proposed as estimates of neural health patterns, in order to explore the extent to which the different measures provide converging and consistent neural health estimates. All measures were obtained from the same 11 users of the Cochlear Corporation CI. The two behavioural measures were multipulse integration (MPI) and the polarity effect (PE), both measured on each of seven electrodes per subject. MPI was measured as the difference between thresholds at 80 pps and 1000 pps, and PE as the difference in thresholds between cathodic- and anodic-centred quadraphasic (QP) 80-pps pulse trains. It has been proposed that good neural health corresponds to a large MPI and to a large negative PE (lower thresholds for cathodic than anodic pulses). The electrophysiological measure was the effect of interphase gap (IPG) on the offset of the ECAP amplitude growth function (AGF), which has been correlated with spiral ganglion neuron density in guinea pigs. This ‘IPG offset’ was obtained on the same subset of electrodes used for the behavioural measures. Despite high test–retest reliability, there were no significant correlations between the neural health estimates for either within-subject comparisons across the electrode array, or between-subject comparisons of the means. A phenomenological model of a population of spiral ganglion neurons was then used to investigate physiological mechanisms that might underlie the different neural health estimates. The combined experimental and modelling results provide evidence that PE, MPI and IPG offset may reflect different characteristics of the electrode-neural interface.
Electronic structure of rare-earth infinite-layer ReNiO2 (Re=La, Nd)
Creators: name: Jiang, Peiheng
name: Si, Liang
name: Liao, Zhaoliang
name: Zhong, Zhicheng
Publisher: name: arXiv
Year: 2019
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: The discovery of infinite layer nickelate superconductor marks the new era in the field of superconductivity. In the rare-earth (Re) nickelates ReNiO2, although the Ni is also of d9 electronic configuration, analogous to Cu d9 in cuprates, whether electronic structures in infinite-layer nickelate are the same as cuprate and possess the single band feature as well are still open questions. To illustrate the electronic structure of rare-earth infinite-layer nickelate, we perform first principle calculations of LaNiO2 and NdNiO2 compounds and compare them with that of CaCuO2 using hybrid functional method together with Wannier projection and group symmetry analysis. Our results indicate that the Ni-dx2-y2 in the LaNiO2 has weak hybridization with other orbitals and exhibits characteristic single band feature, whereas in NdNiO2, the Nd-f orbital hybridizes with Ni-dx2-y2 and is a non-negligible ingredient for transport and even high-temperature superconductivity. Given that the Cu-dx2-y2 in cuprate strongly hybridizes with O-2p, the calculated band structures of nickelate imply some new band characters which is worth to gain more attentions.
Super-slippery Carbon Nanotubes: Symmetry Breaking breaks friction
Creators: name: Damnjanovic, M.
name: Vukovic, T.
name: Milosevic, I.
Publisher: name: arXiv
Year: 2001
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The friction between the walls of multi-wall carbon nanotubes is shown to be extremely low in general, with important details related to the specific choice of the walls. This is governed by a simple expression revealing that the phenomenon is a profound consequence of the specific symmetry breaking: super-slippery sliding of the incommensurate walls is a Goldstone mode. Three universal principles of tribology, offering a recipe for the lubricant selection are emphasized.
description: 4 pages, 2 figures, 1 table; pdf available from: http://www.ff.bg.ac.yu/qmf/qsg_e.htm
A convenient route to synthesize N2-(isobutyryl)-9-(carboxymethyl)guanine for aeg-PNA backbone
Creators: name: Dhrubajyoti Datta
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified

description: Synthesis of exclusive N2-(isobutyryl)-9-(carboxymethyl)guanine, an important moiety for peptide nucleic acid synthesis has been reported through a high-yielding reaction scheme starting from 6-chloro-2-amino purine. Crystal structures of two intermediates confirmed the formation of N9-regioisomer. This new synthetic route can potentially replace the conventional tedious method with moderate overall yield.
Studies of the Temperature-Driven Flow Lines and Phase Transitions in a Two-Dimensional Si/SiGe Hole System
Creators: name: Liang, C. T.
name: Huang, C. F.
name: Cheng, Yu-Ming
name: Huang, Tsai-Yu
name: Chang, Y. H.
name: Chen, Y. F.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We have performed low-temperature transport experiments on a Si/SiGe hole system. The measured transverse and longitudinal condductivities $σ_{xx}$ and $σ_{xy}$ allow us to study the magnetic-field-induced transitions in the system. In particular, we present the first study of the temperature-driven flow lines in the "anomalous Hall insulator" regime near a Landau level filling factor $ν=1.5$. The "anomalous" temperature-driven flow lines could be due to the unusual energy level scheme in a Si/SiGe hole system. Moreover, for $3
description: We correct the errors about the formats for figures in the PDF file
Phenomenology of scotogenic scalar dark matter
Creators: name: Ávila, Ivania M.
name: De Romeri, Valentina
name: Duarte, Laura
name: Valle, José W. F.
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We reexamine the minimal Singlet + Triplet Scotogenic Model, where dark matter is the mediator of neutrino mass generation. We assume it to be a scalar WIMP, whose stability follows from the same $\mathbb{Z} _{2}$ symmetry that leads to the radiative origin of neutrino masses. The scheme is the minimal one that allows for solar and atmospheric mass scales to be generated. We perform a full numerical analysis of the signatures expected at dark matter as well as collider experiments. We identify parameter regions where dark matter predictions agree with theoretical and experimental constraints, such as neutrino oscillations, Higgs data, dark matter relic abundance and direct detection searches. We also present forecasts for near future direct and indirect detection experiments. These will further probe the parameter space. Finally, we explore collider signatures associated with the mono-jet channel at the LHC, highlighting the existence of a viable light dark matter mass range.
description: 25 pages, 13 figures, 4 tables, 2 appendices