Additional file 1 of Regional-based within-year seasonal variations in influenza-related health outcomes across mainland China: a systematic review and spatio-temporal analysis
Creators: name: Diamond, Charlie
name: Gong, Hui
name: Sun, Fiona Yueqian
name: Liu, Yang
name: Quilty, Billy J.
name: Jit, Mark
name: Yang, Juan
name: Yu, Hongjie
name: Edmunds, W. John
name: Baguelin, Marc
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Appendix 1. Database search terms. Appendix 2. Inclusion and exclusion criteria. Appendix 3. Data cleaning and formatting. Appendix 4. Calculating mean monthly rate. Appendix 5. Calculating epidemic duration and onset. Appendix 6. Calculating epidemic intensity. Appendix 7. Calculating long-term trends. Appendix 8. Additional figures and tables. Figure S1. Estimating Beijing province monthly all strain influenza test positivity rate amongst ILI outpatients time-series from multiple eligible studies. Figure S2. Number of studies included in quantitative synthesis by publication year and language. Figure S3. Hierarchical map displaying the number of studies identified reporting suitable time-series data in each administrative region for each influenza health outcome. Figure S4. Comparison between distribution of administrative regions represented by review and mainland China overall, by A) GDP per capita (USD) &amp; B) Total population. Figure S5. Monthly ILI consultation rate among all outpatients, grouped and sorted by province-level latitude. Figure S6. Monthly all-strain influenza test positivity rate amongst ILI outpatients, grouped and sorted by province-level latitude. Figure S7. Monthly strain specific influenza test positivity rates amongst ILI outpatients, grouped and sorted by province-level latitude. Figure S8. Monthly rates of influenza associated health outcomes. A) Influenza test positivity rate among SARI inpatients. B) Influenza-associated excess mortality rate among respiratory mortality (per 100 000 person-years). C) Influenza-associated excess mortality rate among all-cause mortality (per 100 000 person-years). Figure S9. Comparison of province-level pre and post 2009/10 influenza pandemic mean monthly rate (MMR) of all influenza strain test positivity, among ILI outpatient consultations. Figure S10. Mean monthly rate (MMR) of ILI consultation rate among all outpatient consultations. Only post 09/10 pandemic years included. Figure S11. Mean monthly rate (MMR) of all influenza strain test positivity, among ILI outpatient consultations. Only post 09/10 pandemic years included. Figure S12. Mean monthly rate (MMR) of strain specific influenza test positivity, among ILI outpatient consultations. Only post 09/10 pandemic years included. Figure S13. Mean monthly rate (MMR) of multiple influenza associated health outcomes. A) Influenza test positivity rate among SARI inpatients. B) Influenza-associated excess mortality rate among respiratory mortality (per 100 000 person-years). C) Influenza-associated excess mortality rate among all-cause mortality (per 100 000 person-years). Figure S14. Provincial and sub-provincial administrative regions mean monthly rates (MMR) of all-strain influenza test positivity among ILI outpatients, arranged as an approximate geographical representation of mainland China. Figure S15. Mean monthly rate (MMR) cross outcome comparison. Figure S16. Influenza A/H3N2 estimated average epidemic months across mainland China. Figure S17. Influenza A/H1N1pdm09 estimated average epidemic months across mainland China. Figure S18. Influenza B estimated average epidemic months across mainland China. Figure S19. Seasonal decomposition of province-level all-strain influenza test positivity among ILI outpatients. Figure S20. Province-level map of China. Table S1. Final studies included in quantitative synthesis after title, abstract and full text screening.