cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Complex regulations of swarming and surfing motilities in pseudomonas aeruginosa
Creators: name: Yeung, Amy Tsz Yan
Publisher: name: University of British Columbia
Year: 2012

description: To investigate how the complex adaptation process of swarming is regulated, a P. aeruginosa PA14 transposon mutant library was screened for mutants defective in swarming. As a result, 233 mutants exhibiting alterations in swarming phenotypes were identified and 35 of these genes encoded for regulators. Only a few of these regulatory mutants showed significant defects in the production of type IV pili, flagella, or rhamnolipid, each of which is known to be involved in swarming, suggesting that the majority of these regulators control other factors important in swarming. One regulatory mutant with a mutation in the cbrA gene was chosen to be investigated in detail. In addition to swarming motility and carbon source utilization, the sensor kinase CbrA was shown to play regulatory roles in other virulence and virulence-related processes of Pseudomonas, including biofilm formation, cytotoxicity, and antibiotic resistance. Microarray analysis revealed hundreds of dysregulated genes in the cbrA mutant that might contribute to the virulence and virulence-related phenotypes observed in the mutant. Phenotypic and genetic analyses of a cbrB mutant suggested that CbrA modulated swarming, biofilm formation, and cytotoxicity via the CbrB response regulator and that the CrcZ small RNA and the Crc protein are likely downstream of this two-component regulator. Little was known about the mode of motility P. aeruginosa uses to colonize the lungs of patients with cystic fibrosis (CF) since the viscous lung environment in vivo is influenced by mucin in the mucous. To investigate this, the nutritional composition of the CF sputum was mimicked using plates containing synthetic CF medium (SCFM) with mucin. Addition of small amounts (0.05%) of mucin to SCFM-swimming agar led P. aeruginosa to undergo accelerated motility on the surface of the agar. The surface motility colonies in the presence of mucin were circular with a green center surrounded by a thicker white edge. In contrast to swarming, bacterial cells at the edge of the mucin-promoted motility zone appeared piled up and lacked flagella. Using genetic and microscopic methods, it was demonstrated that mucin might be promoting a modified form of swarming or likely a new form of surface motility, termed “surfing”.
Inflation in general covariant theory of gravity
Creators: name: Huang, Yongqing
name: Wang, Anzhong
name: Wu, Qiang
Publisher: name: arXiv
Year: 2012
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this paper, we study inflation in the framework of the nonrelativistic general covariant theory of the Hořava-Lifshitz gravity with the projectability condition and an arbitrary coupling constant $λ$. We find that the Friedmann-Robterson-Walker (FRW) universe is necessarily flat in such a setup. We work out explicitly the linear perturbations of the flat FRW universe without specifying to a particular gauge, and find that the perturbations are different from those obtained in general relativity, because of the presence of the high-order spatial derivative terms. Applied the general formulas to a single scalar field, we show that in the sub-horizon regions, the metric and scalar field are tightly coupled and have the same oscillating frequencies. In the super-horizon regions, the perturbations become adiabatic, and the comoving curvature perturbation is constant. We also calculate the power spectra and indices of both the scalar and tensor perturbations, and express them explicitly in terms of the slow roll parameters and the coupling constants of the high-order spatial derivative terms. In particular, we find that the perturbations, of both scalar and tensor, are almost scale-invariant, and the spectrum indices are the same as those given in GR, but the ratio of the scalar and tensor power spectra depends on the high-order spatial derivative terms, and can be different from that of GR significantly.
description: 19 pages, 0 figures. Version published in JCAP, 10 (2012) 010
Inhibitory Selection Mechanisms in Clinically Healthy Older and Younger Adults
Creators: name: Eich, Teal S.
name: Goncalves, Beatriz M. M.
name: Nee, Derek E.
name: Razlighi, Qolamreza R.
name: Jonides, John
name: Stern, Yaakov
Publisher: name: Columbia University
Year: 2016
Subjects: Neurology
Short-term memory
Cognition
Gerontology

description: OBJECTIVE: Declines in working memory are a ubiquitous finding within the cognitive-aging literature. A unitary inhibitory selection mechanism that serves to guide attention toward task-relevant information and resolve interference from task-irrelevant information has been proposed to underlie such deficits. However, inhibition can occur at multiple time points in the memory-processing stream. Here, we tested whether the time point at which inhibition occurs in the memory-processing stream affects age-related memory decline. METHOD: Clinically healthy younger (n = 23) and older (n = 22) adults performed two similar item-recognition working memory tasks. In one task, participants received an instruction cue telling them which words to attend to followed by a memory set, promoting perceptual inhibition at the time of encoding. In the other task, participants received the instruction cue after they received the memory set, fostering inhibition of items already in memory. RESULTS: We found that older and younger adults differed in their ability to inhibit items both during encoding and when items had to be inhibited in memory but that these age differences were exaggerated when irrelevant information had to be inhibited from memory. These results provide insights into the mechanisms that support cognitive changes to memory processes in healthy aging.
TEACHING STUDENTS FOREIGN LANGUAGES: GAMING ACTIVITY AS THE MAIN FORM OF WORK
Creators: name: Ishonkulov, Sherzod
Publisher: name: Zenodo
Year: 2023

description: The use of gaming activities in foreign language teaching has gained significant traction in recent years. This article explores the potential of gaming as the main form of work in foreign language classrooms. It discusses the theoretical underpinnings of gamification, highlighting its effectiveness in fostering motivation, engagement, and active learning. The article also presents empirical evidence from various studies that demonstrate the positive impact of gaming on foreign language acquisition. It concludes by advocating for the integration of gaming activities into mainstream foreign language teaching methodologies.
On the uniform asymptotic validity of subsampling and the bootstrap
Creators: name: Romano, Joseph P.
name: Shaikh, Azeem M.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Statistics Theory (math.ST)
subject: Methodology (stat.ME)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences

description: This paper provides conditions under which subsampling and the bootstrap can be used to construct estimators of the quantiles of the distribution of a root that behave well uniformly over a large class of distributions $\mathbf{P}$. These results are then applied (i) to construct confidence regions that behave well uniformly over $\mathbf{P}$ in the sense that the coverage probability tends to at least the nominal level uniformly over $\mathbf{P}$ and (ii) to construct tests that behave well uniformly over $\mathbf{P}$ in the sense that the size tends to no greater than the nominal level uniformly over $\mathbf{P}$. Without these stronger notions of convergence, the asymptotic approximations to the coverage probability or size may be poor, even in very large samples. Specific applications include the multivariate mean, testing moment inequalities, multiple testing, the empirical process and U-statistics.
description: Published in at http://dx.doi.org/10.1214/12-AOS1051 the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Coherence and Josephson oscillations between two tunnel-coupled one-dimensional atomic quasicondensates at finite temperature
Creators: name: Grisins, Pjotrs
name: Mazets, Igor E.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We revisit the theory of tunnel-coupled atomic quasicondensates in double-well elongated traps at finite temperatures. Using the functional-integral approach, we calculate the relative-phase correlation function beyond the harmonic limit of small fluctuations of the relative phase and its conjugate relative-density variable. We show that the thermal fluctuations of the relative phase between the two quasicondensates decrease the frequency of Josephson oscillations and even wash out these oscillations for small values of the tunnel coupling.
description: revtex4, 4 figures (.eps)
Inter- and Intraindividual Variability in Recognition Memory: Effects of Aging and Estrogen Use
Creators: name: Wegesin, Domonick
name: Stern, Yaakov
Publisher: name: Columbia University
Year: 2004
Subjects: Neuropsychology
Memory--Age factors
Cognition--Age factors
Estrogen--Therapeutic use

description: Traditionally, studies of cognitive aging have focused on comparing the average performance of younger and older adults, whereas variability around the mean has been attributed to task-irrelevant noise. The present study examined the hypothesis that variability in memory performance increases with age and that estrogen helps temper age-related increases in variability. Postmenopausal estrogen users, estrogen and progestin (est + prog) users, and nonusers, as well as younger women, completed 16 blocks of an item-source memory task. Older women showed greater variability than younger women on measures of dispersion and consistency. Estrogen users, but not est + prog users, performed more consistently than nonusers. Overall, age-related increases in variability differed with the type of variability measured, and estrogen use, but not est + prog use, appeared to reduce age-related increases in at least 1 form of variability.
Canadian clinical nurse specialists : understanding their role in policy within a British Columbian context
Creators: name: Rourke, Sarah Nicole
Publisher: name: University of British Columbia
Year: 2012

description: Clinical Nurses Specialists (CNSs) are in a unique position to respond to the evolution of health care delivery for specialized populations with complex health care needs. Specifically, it has been suggested that CNSs engage with policy at different levels of health care as one way of advancing the nursing profession, improving patient outcomes, and contributing to the provision of effective, sustainable health care. Nevertheless, little is known in regards to CNSs’ experience of policy within their practice, particularly within a Canadian context. Therefore the purpose of this qualitative research study was to explore CNSs’ experience of policy at the clinical, institutional and system levels of the health care system, to further enhance our understanding of CNSs’ practice in Canada, and more specifically British Columbia. Interpretive description was used as the research method for this study. 11 semi-structured interviews were conducted. Through an inductive approach to data analysis involving constant comparison four major themes emerged representing the common reality of the participant’s experience: 1) The Perplexities of Policy; 2) CNSs and Policy: A Perfect Match; 3) CNSs’ Influence: Policy as a Vehicle; and 4) Mechanisms that Challenge and Facilitate CNSs’ Policy Work. Findings of this study confirm and extend what is already known about CNSs’ involvement in policy within a Canadian context. These findings have potential application to practice, education, research and more broadly, the health care system.
Time-reversal symmetric hierarchy of fractional incompressible liquids
Creators: name: Santos, Luiz
name: Neupert, Titus
name: Ryu, Shinsei
name: Chamon, Claudio
name: Mudry, Christopher
Publisher: name: arXiv
Year: 2011
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We provide an effective description of fractional topological insulators that include the fractional quantum spin Hall effect by considering the time-reversal symmetric pendant to the topological quantum field theories that encode the Abelian fractional quantum Hall liquids. We explain the hierarchical construction of such a theory and establish for it a bulk-edge correspondence by deriving the equivalent edge theory for chiral bosonic fields. Further, we compute the Fermi-Bose correlation functions of the edge theory and provide representative ground state wave functions for systems described by the bulk theory.
description: 14 pages
Influence of Education and Occupation on the Incidence of Alzheimer's Disease
Creators: name: Stern, Yaakov
name: Gurland, Barry J.
name: Tatemichi, Thomas K.
name: Tang, Mingxin
name: Wilder, David
name: Mayeux, Richard Paul
Publisher: name: Columbia University
Year: 1994
Subjects: Neurology
Epidemiology
Alzheimer's disease
Education
Occupations

description: Objective. —Several cross-sectional studies have found an association between Alzheimer's disease (AD) and limited educational experience. It has been difficult to establish whether educational experience is a risk factor for AD because educational attainment can influence performance on diagnostic tests. This study was designed to determine whether limited educational level and occupational attainment are risk factors for incident dementia. Design. —Cohort incidence study. Setting. —General community. Participants. —A total of 593 nondemented individuals aged 60 years or older who were listed in a registry of individuals at risk for dementia in North Manhattan, NY, were identified and followed up. Interventions. —We reexamined subjects 1 to 4 years later with the identical standardized neurological and neuropsychological measures. Main Outcome Measure. —Incident dementia. Results. —We used Cox proportional hazards models, adjusting for age and gender, to estimate the relative risk (RR) of incident dementia associated with low educational and occupational attainment. Of the 593 subjects, 106 became demented; all but five of these met research criteria for AD. The risk of dementia was increased in subjects with either low education (RR, 2.02; 95% confidence interval [CI], 1.33 to 3.06) or low lifetime occupational attainment (RR, 2.25; 95% CI, 1.32 to 3.84). Risk was greatest for subjects with both low education and low life-time occupational attainment (RR, 2.87; 95% CI, 1.32 to 3.84). Conclusions. —The data suggest that increased educational and occupational attainment may reduce the risk of incident AD, either by decreasing ease of clinical detection of AD or by imparting a reserve that delays the onset of clinical manifestations.
Limnesia (Limnesia) pseudozelandica Smit & Pešić 2020, n. sp.
Creators: name: Smit, Harry
name: Pešić, Vladimir
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Limnesiidae
Limnesia
Limnesia pseudozelandica

description: Limnesia (Limnesia) pseudozelandica n. sp. Zoobank: 5D994176-715A-4CEE-ACA4-614B050A85D8 (Figures 3 A­D) Material examined. Holotype male, Hapiata Stream, interstitial, Okiwi Bay, South Island, New Zealand, 41°06.167 ′ S 173°40.763 ′ E, alt. ± 50 m asl, 28­ii­2020 (NMNZ). Diagnosis. Dorsum with eight pairs of glandularia, six of these on the dorsal shield. Cx­III with a relatively long, straight medial margin. Gnathosoma attached to a protrusible tube. Acetabula of separate genital plates. Description. Male: Idiosoma dorsally 571 long and 389 wide, ventrally 591 long. Integument lineated, eyes and integument without pigment. Dorsal shield with six pairs of glandularia and the postocularia, dorsal furrow with two pairs of glandularia. Gnathosomal bay pointed posteriorly, Cx­I fused medially. Cxgl­4 on Cx­III, near suture line of Cx­III/IV. No ridge present anterior to insertion of fourth legs. Genital field 118 wide, gonopore 34 long, with three pairs of glandularia, these lying on curved, indistinct genital plates. Gnathosoma elongated, attached to a protrusible tube. Length of P1­5: 20, 64, 60, 90, 40. Palp segments dorsal without stout setae, P2 ventrally with a short, relatively stout seta. Length of I­leg­4­6: 76, 98, 131. Length of IV­leg­4­6: 84, 90, 92; IV­leg­6 with a terminal seta, 62 long. Excretory pore incorporated in ventral shield. Etymology. Named for its superficial resemblance to L. zelandica Cook, 1983. Remarks. With the key of Cook (1983) the new species keys out as L. testacea Hopkins, 1969. Differences with the latter species (in brackets) are the long medial margin of Cx­III (short), no ridge anterior to insertion of fourth legs (with ridge) and the gonopore is shorter. A second species with the dorsal shield with six pairs of glandularia is L. zelandica Cook, 1983. This species has the gnathosoma attached to a protrusible tube too. Differences with the new species (in brackets) are the presence of three pairs of glandularia in the dorsal furrow (two pairs), the presence of a ridge anterior to the insertions of the legs (no ridge), rounded medial margins of Cx­III (straight), and the integument is pigmented (not pigmented).
description: Published as part of Smit, Harry & Pešić, Vladimir, 2020, New records of water mites from New Zealand, with the description of three new genera and ten new species (Acari: Hydrachnidia), pp. 903-950 in Acarologia 60 (4) on page 908, DOI: 10.24349/acarologia/20204410, http://zenodo.org/record/5401542
description: {"references": ["Cook, D. R. 1983. Rheophilic and hyporheic water mites of New Zealand. Contr. Amer. Ent. Inst., 21: 1 - 224.", "Hopkins, C. L. 1969. New species of Limnesia and Tryssaturus (Acari, Hydrachnellae) from New Zealand. Trans. R. Soc. N. Z., Biol. Sci., 11: 89 - 92."]}
A way to deal with the fringe-like pattern in VIMOS-IFU data
Creators: name: Lagerholm, Carina
name: Kuntschner, Harald
name: Cappellari, Michele
name: Krajnovic, Davor
name: McDermid, Richard
name: Rejkuba, Marina
Publisher: name: arXiv
Year: 2012
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The use of integral field units is now commonplace at all major observatories offering efficient means of obtaining spectral as well as imaging information at the same time. IFU instrument designs are complex and spectral images have typically highly condensed formats, therefore presenting challenges for the IFU data reduction pipelines. In the case of the VLT VIMOS-IFU, a fringe-like pattern affecting the spectra well into the optical and blue wavelength regime as well as artificial intensity variations, require additional reduction steps beyond standard pipeline processing. In this research note we propose an empirical method for the removal of the fringe-like pattern in the spectral domain and the intensity variations in the imaging domain. We also demonstrate the potential consequences for data analysis if the effects are not corrected. Here we use the example of deriving stellar velocity, velocity dispersion and absorption line-strength maps for early-type galaxies. We derive for each spectrum, reduced by the ESO standard VIMOS pipeline, a correction-spectrum by using the median of the eight surrounding spectra as a proxy for the unaffected, underlying spectrum. This method relies on the fact that our science targets (nearby ETGs) cover the complete FoV of the VIMOS-IFU with slowly varying spectral properties and that the exact shape of the fringe-like pattern is nearly independent and highly variable between neighboring spatial positions. We find that the proposed correction methods for the removal of the fringe-like pattern and the intensity variations in VIMOS-IFU data-cubes are suitable to allow for meaningful data analysis in our sample of nearby early-type galaxies. Since the method relies on the scientific target properties it is not suitable for general implementation in the pipeline software for VIMOS.
description: 7 pages, 10 figures, accepted for publication in A&A, new version after comments from language editor
The evolution of pebble size and shape in space and time
Creators: name: Domokos, G.
name: Gibbons, G. W.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Geophysics (physics.geo-ph)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We propose a mathematical model which suggests that the two main geological observations about shingle beaches, i.e. the emergence of predominant pebble size ratios and strong segregation by size are interrelated. Our model is a based on a system of ODEs called the box equations, describing the evolution of pebble ratios. We derive these ODEs as a heuristic approximation of Bloore's PDE describing collisional abrasion. While representing a radical simplification of the latter, our system admits the inclusion of additional terms related to frictional abrasion. We show that nontrivial attractors (corresponding to predominant pebble size ratios) only exist in the presence of friction. By interpreting our equations as a Markov process, we illustrate by direct simulation that these attractors may only stabilized by the ongoing segregation process.
description: 22 pages, 8 figures
Influence of Leisure Activity on the Incidence of Alzheimer's Disease
Creators: name: Scarmeas, Nikolaos
name: Levy, Gilberto
name: Tang, Mingxin
name: Manly, Jennifer J.
name: Stern, Yaakov
Publisher: name: Columbia University
Year: 2001
Subjects: Neurology
Alzheimer's disease--Patients--Recreation
Alzheimer's disease
Dementia

description: OBJECTIVE: To determine whether leisure activities modify the risk for incident dementia. BACKGROUND: Although high educational and occupational attainments have been associated with reduced risk of incident dementia, the relation between leisure activities and dementia risk has not been adequately investigated. METHODS: A total of 1,772 nondemented individuals aged 65 years or older, living in northern Manhattan, New York, were identified and followed longitudinally in a community-based cohort incidence study. Subjects' leisure activities at baseline were assessed, annual examinations with the same standardized neurologic and neuropsychological measures were performed for up to 7 years (mean 2.9 years), and incident dementia was assessed as the main outcome measure. Cox proportional hazards models, adjusting for age, ethnic group, education, and occupation, were used to estimate the relative risk (RR) of incident dementia associated with high leisure activities. RESULTS: Of the 1,772 subjects, 207 became demented. The risk of dementia was decreased in subjects with high leisure activities (RR, 0.62; 95% CI 0.46 to 0.83). The association of high leisure with decreased RR of incident dementia was present even when baseline cognitive performance, health limitations interfering with desired leisure activities, cerebrovascular disease, and depression were considered. CONCLUSIONS: The data suggest that engagement in leisure activities may reduce the risk of incident dementia, possibly by providing a reserve that delays the onset of clinical manifestations of the disease
Elliptic flow at varying energy heavy ion collisions: Partonic vs hadronic dynamics
Creators: name: Greco, Vincenzo
name: Mitrovski, Michael
name: Torrieri, Giorgio
Publisher: name: arXiv
Year: 2012
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We examine whether the breakdown in elliptic flow quark number scaling observed at the Relativistic Heavy Ion Collider (RHIC) energy scan is related to the turning off of deconfinement by testing the hypothesis that hydrodynamics and parton coalescence always apply, but are obscured, at lower energies, by variations in the widths of quark and anti-quark rapidity distribution. We find that this effect is enough to spoil quark number scaling in elliptic flow. A lack of scaling in data therefore does not signal the absence of partonic degrees of freedom and hadronization by coalescence. In a coalescing partonic fluid, however, elliptic flow of anti-baryons should be the greater than that of baryons, since antibaryons contain a greater admixture of partons from the highly flowing midrapidity region. Intriguingly, purely hadronic dynamics has a similar dependence of baryon-anti-baryons $v_2$ as purely partonic dynamics, again because antibaryons tend to come from regions where the deviation of the system from hydrodynamic behavior is at its smallest. The opposite trend observed in experiment is therefore an indication that we might be misunderstanding the origin of $v_2$. We finish by discussing possible explanations of this, and suggest experimental measurements capable of clarifying the situation.
description: Final version, to be published by PRC Some clarification and correction in the discussion, typos in equations fixed
Increased Risk of Mortality in Alzheimer's Disease Patients with More Advanced Educational and Occupational Attainment
Creators: name: Stern, Yaakov
name: Tang, Mingxin
name: Denaro, Jean
name: Mayeux, Richard Paul
Publisher: name: Columbia University
Year: 1995
Subjects: Neurology
Alzheimer's disease--Patients
Mortality
Dementia
Education

description: A reserve hypothesis suggests that clinical symptoms of Alzheimer's disease (AD) begin earlier in individuals with less education. Therefore, patients with less education might survive longer after diagnosis than those with more education. Two hundred forty-six subjects with probable AD were following for 1 to 4 years. There were 78 deaths; 30 deaths occurred in the 127 patients whose education was ≤8 years, while 48 deaths occured in the 119 patients with <8 years of education. Cox proportional hazards models adjusted for age, gender, and clinical dementia rating (CDR) showed that patients with more education had increased mortality (continuous variable: RR = 1.06 for each years of education; 95% confidence interval {CI}, 1.01-1.11; dichotomous variable at 8 yr: RR = 1.76; CI, 1.11-2.77). This observation might at first seem counterintuitve, since groups with lower socioeconomic status are often at greater mortality risk. It implies that at any level of assessed clinical severity, the underlying pathology of AD is more advanced in patients with more education, resulting in shorter duration of diagnosed disease before death. These findings suggest either that education systematically influences global ratings of disease severity or that education provides a reserve against the clinical manifestation of AD pathology.
D5.6 - symbIoTe Trials, Deployments & Assessment
Creators: name: Garcia, João
name: Pardi, Matteo
name: Ventura Miravet, Raquel
name: De Santis, Luca
name: Neri, Lorenzo
name: Herzog, Reinhard
name: Jacoby, Michael
name: Mueller, Szymon
name: Kreiner, Karl
name: Antonić, Aleksandar
name: Marjanović, Martina
name: Schroeder, Svenja
name: Drobics, Mario
name: Paradell, Antonio
Publisher: name: Zenodo
Year: 2018
Subjects: IoT
trials
use cases

description: This deliverable provides an overview on how the various trials were designed and evaluated and explains the deployment of the symbIoTe components needed for the various different trials, as well as the specific components used in each use case, and assess the results of the performed trials.
Noninvasive assessment of embryo quality in human in vitro fertilization : metabolomic profiling of embryo culture media with Raman spectroscopy
Creators: name: Asghari Roodsari, Alaleh
Publisher: name: University of British Columbia
Year: 2012

description: Introduction: Light microscopy has remained the primary tool for the assessment of embryo quality and the selection of embryos for transfer in clinical IVF practice. Recent studies have suggested that metabolomic profiling of embryo culture media can distinguish human embryos with better implantation potential. We therefore undertook the following study to further assess the usefulness of metabolomic profiling “spent” embryo culture medium using Raman spectroscopy. Methods: Patients undergoing IVF+/-ICSI treatment from the UBC Centre for Reproductive Health were recruited for study. Demographic and clinical information was collected. As part of routine clinical procedures, embryos were individually cultured in G1 media from Day 1-3 and in G2 media from Day 4-6. G1 and G2 culture medium (vitrolife, Englewood, CO) introduced specifically for cleavage embryo and blastocyst culture respectively. Embryo-free G1 and G2 droplets were placed alongside the embryo-containing ones as controls. For the study, fresh droplets of spent and control culture media were individually collected on Day 3 and 6 and prepared for assessment by Raman spectroscopy. The assessment score under light microscopy of the corresponding embryo and its fate were recorded for comparison and correlation. To validate the detection limits of Raman spectroscopy a wide range of glucose and glycine concentrations between 0 and 500 mM in distilled water were analyzed. Results: A total of 300 embryos/spent media droplets from 54 patients aged 27-43 years (mean age ± SD: 36.33 ± 3.26) were evaluated. Of 111 embryos transferred, 19 implanted and led to a pregnancy: 7 (12.96%) single and 6 (11.1%) twin pregnancies. Irrespective of pregnancy, there were no systematic differences between the Raman spectra generated from spent media of Day 3 and Day 6 embryos, or between spent media and control media. Conclusions: In contrast to published reports, our study does not show that metabolomic profiling of spent embryo culture media by Raman spectroscopy can differentiate embryos with better implantation potential or add value to light microscopic assessment as in clinical practice.
title: How does exploitation of prey fish affect population growth rate in changing seas?
Creators: name: Durant, Joël M.
name: Hidalgo, Manuel
name: Ciannelli, Lorenzo
Publisher: name: ASC 2010 - Theme session R
Year: 2024
Subjects: Pressures, impacts, conservation, and management

description: No abstracts are to be cited without prior reference to the author.Population growth, hence the population’s persistence, is affected by several factors such as climate, species interaction, and harvesting pressure the last having been shown to make the marine populations more sensitive to climate forcing. The age truncated or juvenescent populations are a worldwide consequence of the protracted size-selective mortality of commercial fishing on the older and larger individuals. This process also increases a populations’ ability to directly respond to environmental fluctuations, emphasizing the importance of the interaction between fisheries, environment and internal dynamics that produces complex synergic effects on the population dynamics of marine species. We used a comparative approach investigating commercially fished species on different systems: the Norwegian sea-Barents Sea (Northeast Arctic cod), the Atlantic Ocean (European hake), the Mediterranean Sea (European hake), and the Bering Sea (Pollock). Our objective was to address in a comparative way the ecological consequences of fisheries effect on population properties (e.g., intrinsic growth rate) in relation to different external conditions (fishing intensity or climate). For this, we have applied techniques based upon age-structured population matrices to analyze estimated stock sizes. By combining all sources of information, we investigated differences in the coupling between life history traits and population dynamics for all stocks that display different level of juvenescence. This study will advance our understanding of the underlying mechanisms behind the transitory relationships between climate and fish populations.
Diagnosis of Dementia in a Heterogeneous Population: Development of a Neuropsychological Paradigm-Based Diagnosis of Dementia and Quantified Correction for the Effects of Education
Creators: name: Stern, Yaakov
name: Andrews, Howard F.
name: Pittman, John
name: Sano, Mary
name: Tatemichi, Thomas
name: Lantigua, Rafael Antonio
name: Mayeux, Richard Paul
Publisher: name: Columbia University
Year: 1992
Subjects: Neurology
Diagnosis
Dementia
Neuropsychological tests
Education

description: A brief diagnostic battery of neuropsychological tests was developed for a large-scale epidemiological study of dementia. We operationally defined dementia as defective memory and defective performance in at least two other areas, including orientation, abstract reasoning, construction, and language. Criterion scores for defining defective performance on each test were developed. In a pilot study that used 51 different subjects with a working diagnosis based on physicians' assessment (ie, 32 demented and 29 nondemented subjects), the test-based diagnosis agreed with the working diagnosis in all but two cases. The test battery was then applied to 430 healthy elderly subjects. Eighteen percent of those with 8 or less years of education met criteria for dementia compared with 5% of those with more than 8 years of education. We computed educationcorrected scores for each test with the use of residuals from the regression of each test score on education. Based on corrected scores, 12 subjects were reclassified as nondemented and 11 as demented. Subjects who were reclassified as demented were significantly more impaired in activities of daily living than nondemented subjects who were not reclassified. Activities of daily living in subjects who were reclassified as nondemented did not differ from those in demented subjects who were not reclassified. These findings suggest that the neuropsychological battery may have utility in the diagnosis of dementia. However, neuropsychological performance may be influenced by education, and some form of adjustment, such as correction for activities of daily living, may be required in epidemiological studies.
Pure O-sequences: known results, applications, and open problems
Creators: name: Migliore, Juan
name: Nagel, Uwe
name: Zanello, Fabrizio
Publisher: name: arXiv
Year: 2012
Subjects: subject: Commutative Algebra (math.AC)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: Primary: 05E40. Secondary: 13E10, 13D40, 13H10, 05A16, 06A07

description: This note presents a discussion of the algebraic and combinatorial aspects of the theory of pure O-sequences. Various instances where pure O-sequences appear are described. Several open problems that deserve further investigation are also presented.
description: Some minor revisions with respect to the previous version. 20 pages. To appear in a Springer volume edited by Irena Peeva and dedicated to David Eisenbud on the occasion of his 65th birthday
A diagrammatic description of the equations of motion, current, and noise within the second-order von Neumann approach
Creators: name: Karlström, O.
name: Emary, C.
name: Zedler, P.
name: Pedersen, J. N.
name: Bergenfeldt, C.
name: Samuelsson, P.
name: Brandes, T.
name: Wacker, A.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We investigate the second-order von Neumann approach from a diagrammatic point-of-view and demonstrate its equivalence with the resonant tunneling approximation. Investigation of higher-order diagrams shows that the method correctly reproduces the equation of motion for the single-particle reduced density matrix of an arbitrary non-interacting many-body system. This explains why the method reproduces the current exactly for such systems. We go on to show, however, that diagrams not included in the method are needed to calculate exactly higher cumulants of the charge transport. This thorough comparison sheds light on the validity of all these self consistent second-order approaches. We analyze the discrepancy between the noise calculated by our method and the exact Levitov formula for a simple non-interacting quantum dot model. Furthermore we study the noise of the canyon of current suppression in a two-level dot, a phenomenon that requires the inclusion of electron-electron interaction as well as higher-order tunneling processes.
description: 27 pages, 14 figures
VERITAS observations of the Segue 1 dwarf spheroidal galaxy
Creators: name: Vivier, Matthieu
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: In the cosmological paradigm, cold dark matter dominates the mass content of the Universe and is present at every scale. Candidates for dark mater include many extensions of the standard model, with a Weakly Interacting Massive Particle (WIMP) in the mass range from 50 GeV to greater than 10 TeV. The self-annihilation of WIMPs in astrophysical regions of high dark matter density can produce secondary particles including Very High Energy (VHE) gamma rays with energies up to the dark matter particle mass. The VERITAS array of Cherenkov telescopes, designed for the detection of VHE gamma rays in the 100 GeV-10 TeV energy range, is an appropriate instrument for the detection of dark matter. Among the possible astrophysical targets, dwarf spheroidal galaxies (dSphs) of the Local Group are promising targets to search for the annihilation signature of dark matter due to their proximity and large dark matter content. We report here on extensive observations conducted by VERITAS on the nearby Segue 1 satellite galaxy, which is currently considered as one of the best dSphs for dark matter studies. The results are discussed in the framework of WIMP models, with a special emphasis on leptophilic DM models invoked to explain the recent cosmic ray lepton anomalies.
description: 4 pages, 3 figures, Proceeding of the 32nd International Cosmic Ray Conference (Beijing 2011). Reference list updated in v3
Incidence of AD in African-Americans, Caribbean Hispanics, and Caucasians in Northern Manhattan
Creators: name: Tang, Mingxin
name: Cross, Peter
name: Andrews, Howard F.
name: Jacobs, Diane
name: Small, Scott A.
name: Bell, Karen L.
name: Merchant, Carol
name: Lantigua, Rafael Antonio
name: Costa, Rosanne
name: Stern, Yaakov
name: Mayeux, Richard Paul
Publisher: name: Columbia University
Year: 2001
Subjects: Neurology
Alzheimer's disease
Cerebrovascular disease
Epidemiology

description: Objective: To compare the incidence rates for AD among elderly African-American, Caribbean Hispanic, and white individuals and to determine whether coincident cerebrovascular disease contributes to the inconsistency in reported differences among ethnic groups. Methods: This was a population-based, longitudinal study over a 7-year period in the Washington Heights and Inwood communities of New York City. Annual incidence rates for AD were calculated and compared by ethnic group, and cumulative incidence adjusted for differences in education, diabetes, cardiovascular risk factors, and stroke was calculated. Results: The age-specific incidence rate for probable and possible AD was 1.3% (95% CI, 0.8 to 1.7) per person-year between the ages of 65 and 74 years, 4.0% (95% CI, 3.2 to 4.8) per person-year between ages 75 and 84 years, and 7.9% (95% CI, 5.5 to 10.5) per person-year for ages 85 and older. Compared to white individuals, the cumulative incidence of AD to age 90 years was increased twofold among African-American and Caribbean Hispanic individuals. Adjustment for differences in number of years of education, illiteracy, or a history of stroke, hypertension, heart disease, or diabetes did not change the disproportionate risks among the three ethnic groups. Conclusion: The incidence rate for AD was significantly higher among African-American and Caribbean Hispanic elderly individuals compared white individuals. The presence of clinically apparent cardiovascular or cerebrovascular disease did not contribute to the increased risk of disease. Because the proportion of African-American and Caribbean Hispanic individuals reaching ages 65 and older in the United States is increasing more rapidly than the proportion of white individuals, it is imperative that this disparity in health among the elderly be understood.
On the internal distance in the interlacement set
Creators: name: Černý, Jiří
name: Popov, Serguei
Publisher: name: arXiv
Year: 2011
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60K35, 82B43

description: We prove a shape theorem for the internal (graph) distance on the interlacement set $\mathcal{I}^u$ of the random interlacement model on $\mathbb Z^d$, $d\ge 3$. We provide large deviation estimates for the internal distance of distant points in this set, and use these estimates to study the internal distance on the range of a simple random walk on a discrete torus.
description: 26 pages, 3 figures
Asperaturus petiolatus Smit & Pešić 2020, n. sp.
Creators: name: Smit, Harry
name: Pešić, Vladimir
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Aturidae
Asperaturus
Asperaturus petiolatus

description: Asperaturus petiolatus n. sp. Zoobank: 10B3979D-A5B4-481C-A52A-1E79B7682351 (Figures 15 A­B, 16A­E) Material examined. Holotype male, Deep Creek at crossing with Bell Hill Road, Moana, South Island, New Zealand, 42°33.071 ′ S 171°36.014 ′ E, alt. 245 m asl, 4­iv­2020 (NMNZ). Description. Male: Idiosoma dorsally 486 long and 365 wide, ventrally 543 long. Integument rugose, frontal margin of dorsum concave, posterolaterally with two large triangular tubercles. Dorsal shield 365 long and 324 wide, with unpaired antero­ and posteromedial plates and two pairs of lateral platelets, anterolateral platelets with a pair of glandularia, posterolateral platelets without glandularia. Anteromedial plate with a pair of postocularia, 154 long and 219 wide. A pair of “free” glandularia located between lateral platelets and posteromedial plate, the latter with two pairs of glandularia. Dorsum posteriorly with a petiolus­like elongated extension. Suture lines of coxae incomplete, Cxgl­2 near suture line of Cx­III and Cx­IV. Posterior margin of Cx­IV indistinct and partly obsolete. Projections associated with insertions of fourth legs truncate. Gonopore 42 long, relatively wide, genital field with 10­12 pairs of acetabula lateral to the gonopore. Posterior margin of venter with a triangular, somewhat hyaline extension. Excretory pore dorsally, posterior to the dorsal shield. Length of P1­5: 30, 53, 31, 61, 28. P2 anteroventrally with a number of teeth, P4 ventrally somewhat bulging and a ridge in anterior half of segment. Length of I­leg­4­6: 68, 70, 68. I­leg­6 with a long ventral seta. Length of IV­leg: 109, 77, 59, 73, 84, 73. IV­L­2 with a distoanterior extension. Female: Unknown. Etymology. Named for the presence of a petiole­like structure.
description: Published as part of Smit, Harry & Pešić, Vladimir, 2020, New records of water mites from New Zealand, with the description of three new genera and ten new species (Acari: Hydrachnidia), pp. 903-950 in Acarologia 60 (4) on page 928, DOI: 10.24349/acarologia/20204410, http://zenodo.org/record/5401542
Strings from geometric tachyon in Rindler space and black hole thermodynamics
Creators: name: Li, Huiquan
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The dynamics of a probe particle or wrapped brane moving in the two-dimensional Rindler space can be described by a time-dependent tachyon field theory. Using knowledge of tachyon condensation, we learn that the infalling brane gets thermalised and produces open string pairs at the Hagedorn temperature when entering into the near-horizon Rindler wedge. It is shown that the Hagedorn temperature of the infalling brane is equal to the Hawking temperature of the host black hole detected in the same time coordinate. The infalling brane will decay completely into closed strings, mainly massive modes, when it reaches the horizon in infinitely long time as observed by observers at spatial infinity. Preliminary estimates indicate that the degeneracy of states of the closed strings emitted from the infalling brane should be responsible for the increased entropy in the host black hole due to absorption of the brane.
description: 12 pages
White Matter Hyperintensities and Cognition: Testing the Reserve Hypothesis
Creators: name: Brickman, Adam M.
name: Siedlecki, Karen L.
name: Muraskin, Jordan Scott
name: Manly, Jennifer J.
name: Luchsinger, Jose A.
name: Yeung, Lok-Kin
name: Brown, Truman R.
name: DeCarli, Charles
name: Stern, Yaakov
Publisher: name: Columbia University
Year: 2011
Subjects: Neurobiology
Aging
Cognition
Magnetic resonance imaging

description: OBJECTIVE: White matter hyperintensities (WMH), visualized on T2-weighted MRI, are thought to reflect small-vessel vascular disease. Much like other markers of brain disease, the association between WMH and cognition is imperfect. The concept of reserve may account for this imperfect relationship. The purpose of this study was to test the reserve hypothesis in the association between WMH severity and cognition. We hypothesized that individuals with higher amounts of reserve would be able to tolerate greater amounts of pathology than those with lower reserve. METHODS: Neurologically healthy older adults (n=717) from a community-based study received structural MRI, neuropsychological assessment, and evaluation of reserve. WMH volume was quantified algorithmically. We derived latent constructs representing four neuropsychological domains, a measure of cognitive reserve, and a measure of brain reserve. Measures of cognitive and brain reserve consisted of psychosocial (e.g., education) and anthropometric (e.g., craniometry) variables, respectively. RESULTS: Increased WMH volume was associated with poorer cognition and higher cognitive and brain reserve were associated with better cognition. Controlling for speed/executive function or for language function, those with higher estimates of cognitive reserve had significantly greater degrees of WMH volume, particularly among women. Controlling for cognitive functioning across all domains, individuals with higher estimates of brain reserve had significantly greater WMH volume. CONCLUSIONS: For any given level of cognitive function, those with higher reserve had more pathology in the form of WMH, suggesting that they are better able to cope with pathology than those with lower reserve. Both brain reserve and cognitive reserve appear to mitigate the impact of pathology on cognition.
Documentary Evidence and its Potential for Understanding the Inland Movement of Medieval Pottery
Creators: name: Moorhouse, Stephen A
Publisher: name: Archaeology Data Service
Year: 2023

description: Medieval Ceramics: Journal of the Medieval Ceramics Research Group, 7, 45-88
description: Documentary evidence offers numerous suggestions for the understanding of the movement of pottery. Insights can be gained into pottery distributions by considering, for example, the location of medieval roads, towns, markets and fairs, and by studying manorial and epicopal accounts. As historical documents are open to many different interpretations, the key to understanding the significance of these pottery distributions must come from a close working relationship between archaeologists and historians.