cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Ahp-enhanced swot matrix teaching strategy / Estrategia de enseñanza de la matriz foda extendida con Ahp
Creators: name: Repositorio Academico UPC
name: Quevedo, Mario Chipoco
Publisher: name: figshare
Year: 2016
Subjects: Education

description: The SWOT matrix is the quintessential analysis tool for business purposes, and is taught both in undergraduate and postgraduate courses. However, it is widely understood that the selection of the critical success factors (CSFs) that are included for analysis in the matrix is a very subjective and unstructured process, leaving room for bias and arbitrariness. One way to give a better foundation and support to the analysis results is by utilizing Analytic Hierarchical Process (AHP) in order to weigh the importance of CSFs in the SWOT matrix and increase reliability of the output. This paper contains the design of a strategy to teach this topic in a marketing planning course, with the addition of a useful technique to overcome the limitations of the tool.
La matriz FODA es la herramienta de análisis por excelencia para fines de negocios, y se enseña en cursos de pregrado y postgrado. Sin embargo, se entiende que la elección de los factores críticos de éxito (FCEs) que se incluyen en la matriz para el análisis es un proceso muy subjetivo y no estructurado, que da cabida a sesgos y arbitrariedad. Una forma de dar una mejor base y respaldo a los resultados del análisis es mediante la utilización del Proceso Jerárquico Analítico (AHP) con el fin de ponderar la importancia de los FCEs en la matriz FODA y aumentar la fiabilidad de los resultados. Este documento contiene el diseño de una estrategia para enseñar este tema en un curso de planificación de marketing, con la adición de una técnica útil para superar las limitaciones de la herramienta.
AUTOR: Chipoco Quevedo, MarioEDITORIAL: UniversidadPeruana de Ciencias Aplicadas (UPC)REVISTA: Revista Digital deInvestigación en Docencia Universitaria (RIDU)FECHA DE PUBLICACIÓN: Diciembre 2015URL: http://hdl.handle.net/10757/604959ENLACES ADICIONALES: http://revistas.upc.edu.pe/index.php/docencia/article/view/445
PDF: Texto completo / Full text
Additional file 2 of Time-varying intensity of oxygen exposure is associated with mortality in critically ill patients with mechanical ventilation
Creators: name: Zhu, Zhu
name: Zhou, Mingqin
name: Wei, Yao
name: Chen, Hui
Publisher: name: figshare
Year: 2022
Subjects: Biophysics
Medicine
Cell Biology
Biotechnology
Biological Sciences not elsewhere classified
Science Policy
Computational Biology

description: Additional file 2. Table S1: Baseline characteristics and outcomes of patients stratified by TWA-PaO2 on Day 1; Table S2: Baseline characteristics and outcomes of patients stratified by TWA-FiO2 on Day 1; Table S3: Effect of time-varying TWA-PaO2 and TWA-FiO2 on 28-day mortality of 7784 patients with mechanical ventilation; Table S4: Effect of time spent with hyperoxemia and high FiO2 on 28-day mortality of 7784 patients with mechanical ventilation; Table S5: Effect of cumulative exposure of hyperoxemia and high FiO2 on 28-day mortality of 7784 patients with mechanical ventilation; Table S6: Effect of time-varying hyperoxemia and high FiO2 on 28-day mortality after excluding missing data of daily TWA-PaO2 or TWA-FiO2; Table S7: Effect of time-varying hyperoxemia and high FiO2 on 28-day mortality in patients with mechanical ventilation, patients were followed up from inclusion until death, liberated from mechanical ventilation, ICU discharge, or 28 days in the ICU, whichever occurred first; Figure S1: Study flow diagram in present study. Figure S2: Time-varying effect of TWA-PaO2 (A) or TWA-FiO2 (B) on 28-day mortality
Referências Poster ER2LS-Efeito de microplásticos de filme mulching de diferentes formulações sobre o tomate (Solanum lycopersicum)
Creators: name: Sebastião, Glaucia Isabel de Andrade
name: Barbosa, Alice Pita
name: Waldman, Walter Ruggeri
Publisher: name: Zenodo
Year: 2024

description: Referências do poster apresentado na 7ª edição da Escola Ricardo Rodrigues de Luz Síncrotron (ER2LS).
Study of dose-dependent combination immunotherapy using engineered T cells and IL-2 in cervical cancer
Creators: name: Cho, Heyrim
name: Wang, Zuping
name: Levy, Doron
Publisher: name: arXiv
Year: 2020
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: Tissues and Organs (q-bio.TO)
subject: FOS: Biological sciences
subject: 92B05

description: Adoptive T cell based immunotherapy is gaining significant traction in cancer treatment. Despite its limited success, so far, in treating solid cancers, it is increasingly successful, demonstrating to have a broader therapeutic potential. In this paper we develop a mathematical model to study the efficacy of engineered T cell receptor (TCR) T cell therapy targeting the E7 antigen in cervical cancer cell lines. We consider a dynamical system that follows the population of cancer cells, TCR T cells, and IL-2. We demonstrate that there exists a TCR T cell dosage window for a successful cancer elimination that can be expressed in terms of the initial tumor size. We obtain the TCR T cell dose for two cervical cancer cell lines: 4050 and CaSki. Finally, a combination therapy of TCR T cell and IL-2 treatment is studied. We show that certain treatment protocols can improve therapy responses in the 4050 cell line, but not in the CaSki cell line.
description: 8 pages, 7 figures
Additional file 1 of Time-varying intensity of oxygen exposure is associated with mortality in critically ill patients with mechanical ventilation
Creators: name: Zhu, Zhu
name: Zhou, Mingqin
name: Wei, Yao
name: Chen, Hui
Publisher: name: figshare
Year: 2022
Subjects: Biophysics
Medicine
Cell Biology
Biotechnology
Biological Sciences not elsewhere classified
Science Policy
Computational Biology

description: Additional file 1. : Codes for piece-wise exponential additive mixed models
Convergence of a Fully Discrete and Energy-Dissipating Finite-Volume Scheme for Aggregation-Diffusion Equations
Creators: name: Bailo, Rafael
name: Carrillo, Jose A.
name: Murakawa, Hideki
name: Schmidtchen, Markus
Publisher: name: arXiv
Year: 2020
Subjects: subject: Numerical Analysis (math.NA)
subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: We study an implicit finite-volume scheme for non-linear, non-local aggregation-diffusion equations which exhibit a gradient-flow structure, recently introduced by Bailo, Carrillo, and Hu (2020). Crucially, this scheme keeps the dissipation property of an associated fully discrete energy, and does so unconditionally with respect to the time step. Our main contribution in this work is to show the convergence of the method under suitable assumptions on the diffusion functions and potentials involved.
Study on synthesis, characterizations, and properties of pyridinol-blocked isocyanates and waterborne polyurethane
Creators: name: Guo, Sen
name: Yongkun Zou
name: Jingwei He
name: Liu, Fang
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: A series of pyridinol-blocked isophorone isocyanates were synthesized through esterification reaction, Fries rearrangement, and blocking reaction and characterized by 1H-NMR, 13C-NMR, and Fourier transform infrared spectra. Based on the synthesized blocked isocyanates, the blocked waterborne polyurethane (BWPU) was prepared by the self-emulsification method. The deblocking studies revealed that the deblocking temperature reduces with electron-withdrawing and steric hindrance substituents on the ortho position of pyridinol. The stability, molecular weight (Mw), particle size, viscosity, and hydrophilicity of BWPU were studied and compared. The results showed that with an increased amount of blocking agents, molecular weight, particle size, and viscosity decrease and the hydrophilicity increases.
Some multivariate master polynomials for permutations, set partitions, and perfect matchings, and their continued fractions
Creators: name: Sokal, Alan D.
name: Zeng, Jiang
Publisher: name: arXiv
Year: 2020
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05A19 (Primary), 05A05, 05A10, 05A15, 05A18, 05A30, 30B70, 33C45, 33D45 (Secondary)

description: We find Stieltjes-type and Jacobi-type continued fractions for some "master polynomials" that enumerate permutations, set partitions or perfect matchings with a large (sometimes infinite) number of simultaneous statistics. Our results contain many previously obtained identities as special cases, providing a common refinement of all of them.
description: LaTeX2e, 122 pages, includes 9 tikz figures. Version 2 includes a new footnote 27 on page 81. To be published in Advances in Applied Mathematics
Additional file 1 of Dietary inflammatory potential and the incidence of depression and anxiety: a meta-analysis
Creators: name: Li, Xiaoling
name: Chen, Meicui
name: Yao, Zhicui
name: Zhang, Tianfeng
name: Li, Zengning
Publisher: name: figshare
Year: 2022
Subjects: subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health
subject: Hematology

description: Additional file1: PRISMA checklist.
Bardeen Black Holes in the Regularized $4D$ Einstein--Gauss--Bonnet Gravity
Creators: name: Kumar, Arun
name: Walia, Rahul Kumar
name: Ghosh, Sushant G.
Publisher: name: arXiv
Year: 2020
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We obtain exact Bardeen black holes to the regularized $4D$ Einstein--Gauss--Bonnet (EGB) gravity minimally coupled with the nonlinear electrodynamics (NED). In turn, we analyze the horizon structure to determine the effect of GB parameter $α$ on the minimum cutoff values of mass, $M_0$, and magnetic monopole charge, $g_0$, for the existence of a black hole horizon. We obtain an exact expression for thermodynamic quantities, namely, Hawking temperature $T_+$, entropy $S_+$, Helmholtz free energy $F_+$, and specific heat $C_+$ associated with the black hole horizon, and they show significant deviations from the $4D$ EGB case owing to NED. Interestingly, there exists a critical value of horizon radius, $r_+^{c}$, corresponding to the local maximum of Hawking temperature, at which heat capacity diverges, confirming the second-order phase transition. A discussion on the black holes of alternate regularized $4D$ EGB gravity belonging to the scalar-tensor theory is appended.
description: 15 pages and 4 figures. This was an invited manuscript published in the special issue "Dark Matter and Dark Energy: Particle Physics, Cosmology, and Experimental Searches"
Additional file 2 of Dietary inflammatory potential and the incidence of depression and anxiety: a meta-analysis
Creators: name: Li, Xiaoling
name: Chen, Meicui
name: Yao, Zhicui
name: Zhang, Tianfeng
name: Li, Zengning
Publisher: name: figshare
Year: 2022
Subjects: subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health
subject: Hematology

description: Additional file 2: References of studies excluded in the meta-analysis.
Nonsingular Black Holes in $4D$ Einstein--Gauss--Bonnet Gravity
Creators: name: Kumar, Arun
name: Baboolal, Dharmanand
name: Ghosh, Sushant G.
Publisher: name: arXiv
Year: 2020
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Recently, several methods have been proposed to regularize a $D \to 4$ limit of Einstein-Gauss-Bonnet (EGB), leading to nontrivial gravitational dynamics in $4D$. We present an exact nonsingular black hole solution in the $4D$ EGB gravity coupled to non-linear electrodynamics and analyze their thermodynamic properties to calculate precise expressions for the black hole mass, temperature, and entropy. Because of the magnetic charge, the thermodynamic quantities are corrected, and the Hawking--Page phase transition is achievable with diverges of the heat capacity at a larger critical radius $r=r_{+}^{C}$ in comparison to the $5D$ counterpart where the temperature is maximum. Thus, we have a black hole with Cauchy and event horizons, and its evaporation leads to a thermodynamically stable extremal black hole remnant with vanishing temperature, and its size is larger than the $5D$ counterpart. The entropy does not satisfy the usual exact horizon Bekenstein--Hawking area law of general relativity with a logarithmic area correction term.
description: 5 figures, 3 tables. This was an invited manuscript published in the special issue "Dark Matter and Dark Energy: Particle Physics, Cosmology, and Experimental Searches". Matched to published version
Additional file 3 of Dietary inflammatory potential and the incidence of depression and anxiety: a meta-analysis
Creators: name: Li, Xiaoling
name: Chen, Meicui
name: Yao, Zhicui
name: Zhang, Tianfeng
name: Li, Zengning
Publisher: name: figshare
Year: 2022
Subjects: subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health
subject: Hematology

description: Additional file 3: Methodological quality of the included studies.
Study on Synthesis, Characterizations and Properties of Pyridinol Blocked Isocyanates and Waterborne Polyurethane
Creators: name: Guo, Sen
name: Yongkun Zou
name: Jingwei He
name: Liu, Fang
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 60506 Virology
subject: FOS: Biological sciences

description: A series of pyridinol blocked isophorone isocyanates was synthesized through esterification reaction, Fries rearrangement and blocking reaction, and characterized by 1H-NMR, 13C-NMR and FTIR spectra. Based on the synthesized blocked isocyanates, the blocked waterborne polyurethane was prepared by the self-emulsification method. The deblocking studies revealed that the deblocking temperature reduces with electron-withdrawing and steric hindrance substituents on the ortho-position of pyridinol. The stability, molecular weight, particle size, viscosity, and hydrophilicity of blocked waterborne polyurethane were studied and compared. The results showed that with increased amount of blocking agents, molecular weight, particle size and viscosity reduces and the hydrophilicity enhances.
Making the Case for Investing in Adolescent Reproductive Health
Creators: name: Merrick, Tom
Publisher: name: figshare
Year: 2016
Subjects: Uncategorized

description: Solid evidence on the links between preventing adolescent childbearing and alleviating poverty can motivate policymakers and donors to invest in reproductive health and family planning programs for youth. Research that documents the clear cause-and-effect relationship between program interventions and outcomes, such as better health and delayed childbearing among teens, can guide decisions about investments in research or programs.
This report examines the evidence for investing in adolescent reproductive health and family planning programs from the perspective of making an evidence-based argument to guide the investment or spending decisions of public or private organizations. Key steps in developing such an argument—a business case—include:1. The consequences of relevant trends.2. Evidence on the potential of particular actions or interventions to change the status quo.3. The costs associated with different actions.
Communicating Research: Policymakers' Perspective
Creators: name: Lee, Marlene
Publisher: name: figshare
Year: 2016
Subjects: Uncategorized

description: This policy brief summarizes policymakers’ perspectives on what constitutes barriers to evidence-informed policymaking. It also presents strategies for making research results more accessible to high-level policymakers at the country level, based on what they say they want as well as evidence about what information policymakers can and do use in policymaking. Finally, the brief includes examples of how PopPov-supported researchers addressed policy-relevant questions and applied some of the outreach strategies that policymakers suggest.
Metathesis and unmetathesis in Amarasi
Creators: name: Edwards, Owen
Publisher: name: Freie Universität Berlin
Year: 2020
Subjects: subject: Amaras
subject: Methathesis
subject: language of western Timor
subject: 400 Sprache::410 Linguistik::410 Linguistik

description: This book provides a complete analysis of synchronic CV -> VC metathesis in Amarasi, a language of western Timor. Metathesis and unmetathesis realise a paradigm of parallel forms, pairs of which occur to complement each other throughout the language. Metathesis in Amarasi is superficially associated with a bewildering array of disparate phonological processes including: vowel deletion, consonant deletion, consonant insertion and multiple kinds of vowel assimilation, any of which can (and do) vary by lect in their realisation. By proposing that Amarasi has an obligatory CVCVC foot in which C-slots can be empty, all these phonological processes can be straightforwardly derived from a single rule of metathesis and two associated phonological rules. Three kinds of metathesis can be identified in Amarasi: (i) Before vowel initial enclitics, roots must undergo metathesis, responding to the need to create a phonological boundary between a clitic host and enclitic. Such metathesis is phonologically conditioned. (ii) Metathesis occurs within the syntax to signal attributive modification. Such a metathesised form cannot occur at the end of a phrase and thus requires the presence of an unmetathesised form to complete it syntactically. (iii) In the discourse an unmetathesised form marks an unresolved event or situation. Such an unmetathesised form cannot occur in isolation and requires a metathesised form to achieve resolution. Metathesis in Amarasi is the central linguistic process around which linguistic structures are organised. Amarasi metatheses also reflect fundamental Timorese notions of societal and cosmic organisation. Alongside weaving and other performed activities, metathesis is an important linguistic marker of identity in a region obsessed with similarities and differences between different groups. The complementarity of Amarasi metathesis and unmetathesis within the syntax and within discourse reflects the Timorese division of the world into a series of mutually dependent binary and complementary pairs. As well as being the key which unlocks the structure of the language, metathesis is also a reflection of the structure of Amarasi society and culture. This book is complemented by a dataset available at https://doi.org/10.18710/IORWF6
Minority Oversampling for Imbalanced Time Series Classification
Creators: name: Zhu, Tuanfei
name: Luo, Cheng
name: Li, Jing
name: Ren, Siqi
name: Zhang, Zhihong
Publisher: name: arXiv
Year: 2020
Subjects: subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: Many important real-world applications involve time-series data with skewed distribution. Compared to conventional imbalance learning problems, the classification of imbalanced time-series data is more challenging due to high dimensionality and high inter-variable correlation. This paper proposes a structure preserving Oversampling method to combat the High-dimensional Imbalanced Time-series classification (OHIT). OHIT first leverages a density-ratio based shared nearest neighbor clustering algorithm to capture the modes of minority class in high-dimensional space. It then for each mode applies the shrinkage technique of large-dimensional covariance matrix to obtain accurate and reliable covariance structure. Finally, OHIT generates the structure-preserving synthetic samples based on multivariate Gaussian distribution by using the estimated covariance matrices. Experimental results on several publicly available time-series datasets (including unimodal and multimodal) demonstrate the superiority of OHIT against the state-of-the-art oversampling algorithms in terms of F1, G-mean, and AUC.
Additional file 1 of Collagen-induced assembly of adenosine monophosphate-modified gold nanoparticles for photothermal cancer therapy
Creators: name: Qu, Xinyu
name: Chen, Yixing
name: Cai, Zhuyun
name: Zhao, Xinyu
name: Zeng, Hua
name: Liu, Xiaohao
name: Tan, Shuo
name: Lu, Bingqiang
name: Gao, Rui
name: Chen, Feng
Publisher: name: figshare
Year: 2022
Subjects: Space Science
Physical Sciences not elsewhere classified
Medicine
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Cancer

description: Additional file 1: Figure S1. Zeta potential of AAu sample. Figure S2. Photothermal conversion efficiency of the AAu sample at different laser powers and different AAu concentrations. Figure S3. Temperature changes of CAAu NPs suspensions upon multiple laser on/off cycles (808 nm, 1.5 W). Figure S4. (A) The TEM image and (B) absorption spectrum of the CAAu after irradiation with 808 laser for 10 min. Figure S5. Snap photos of B16-F10 cells after co-incubation with AAu NPs for 24 h at different time intervals: (A) 0 s; (B) 1 s; (C) 2 s; and (D) 3 s, showing that the cell can actively grasp the AAu material, which indicates that the AAu NPs has good biocompatibility. Figure S6. The cytotoxicity of AAu to B16-F10 cells under near-infrared radiation was evaluated. (A) Fluorescent images of B16-F10 cells co-incubated with AAu NPs at the concentration of 20 μg/mL for 2 h with or without irradiation of an 808 nm NIR laser at various power densities (power: 0, 0.5, 1.5 and 2.5 W; spot size: 0.785 cm2). (B) Fluorescent images of B16-F10 cells co-incubated with AAu NPs at various concentrations (i.e., 0, 5, 10, 20 and 40 μg/mL) for 2 h with or without laser irradiation (power: 1.5 W; spot size: 0.785 cm2). (C) Fluorescent images of B16-F10 cells co-incubated with AAu NPs at the concentration of 20 μg/mL for 2 h with or without laser irradiation (power: 1.5 W; spot size: 0.785 cm2) for various time (i.e., 0, 0.5, 1, 2, 5, 10 min). The cells were stained to show living (green) and dead cells (red) under fluorescence microscope. Figure S7. Fluorescent images of live (green) and dead cells (red) after co-incubation with AAu nanoparticles with various concentrations (i.e., 0, 5, 10, 20 and 40 μg/mL) for different time: (A) 24 h or (B) 48 h. Scale bar: 200 μm. Figure S8. Schematic illustration of the animal experimental design of the photothermal therapy for melanoma. Figure S9. The Au elemental concentration normalized to mass of different organs taken from one mouse on the day 10 (i.e., one day after the last treatment). The relatively high Au amount in kidney indicates that the AAu NPs can be excreted from the body through kidney due to its small size. Table S1. The calculated extinction coefficients (L·mmol–1·cm–1) of AAu and CAAu [1].
Nash Equilibrium Seeking Over Directed Graphs
Creators: name: Tang, Yutao
name: Yi, Peng
name: Zhang, Yanqiong
name: Liu, Dawei
Publisher: name: arXiv
Year: 2020
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics

description: In this paper, we aim to develop distributed continuous-time algorithms over directed graphs to seek the Nash equilibrium in a noncooperative game. Motivated by the recent consensus-based designs, we present a distributed algorithm with a proportional gain for weight-balanced directed graphs. By further embedding a distributed estimator of the left eigenvector associated with zero eigenvalue of the graph Laplacian, we extend it to the case with arbitrary strongly connected directed graphs having possible unbalanced weights. In both cases, the Nash equilibrium is proven to be exactly reached with an exponential convergence rate. An example is given to illustrate the validity of the theoretical results.
description: 13 pages
Anyon Quantum Transport and Noise away from Equilibrium
Creators: name: Mintchev, Mihail
name: Sorba, Paul
Publisher: name: arXiv
Year: 2020
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mathematical Physics (math-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We investigate the quantum transport of anyons in one space dimension. After establishing some universal features of non-equilibrium systems in contact with two heat reservoirs in a generalised Gibbs state, we focus on the abelian anyon solution of the Tomonaga-Luttinger model possessing axial-vector duality. In this context a non-equilibrium representation of the physical observables is constructed, which is the basic tool for a systematic study of the anyon particle and heat transport. We determine the associated Lorentz number and describe explicitly the deviation from the standard Wiedemann-Franz law induced by the interaction and the anyon statistics. The quantum fluctuations generated by the electric and helical currents are investigated and the dependence of the relative noise power on the statistical parameter is established.
description: LaTex, 10 pages, 6 figures
ADAR1 deletion induces NFκB and interferon signaling dependent liver inflammation and fibrosis
Creators: name: Ben-Shoshan, Shirley Oren
name: Kagan, Polina
name: Sultan, Maya
name: Barabash, Zohar
name: Dor, Chen
name: Jacob-Hirsch, Jasmine
name: Harmelin, Alon
name: Pappo, Orit
name: Marcu-Malina, Victoria
name: Ben-Ari, Ziv
name: Amariglio, Ninette
name: Rechavi, Gideon
name: Goldstein, Itamar
name: Safran, Michal
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Adenosine deaminase acting on RNA (ADAR) 1 binds and edits double-stranded (ds) RNA secondary structures found mainly within untranslated regions of many transcripts. In the current research, our aim was to study the role of ADAR1 in liver homeostasis. As previous studies show a conserved immunoregulatory function for ADAR1 in mammalians, we focused on its role in preventing chronic hepatic inflammation and the associated activation of hepatic stellate cells to produce extracellular matrix and promote fibrosis. We show that hepatocytes specific ADAR1 knock out (KO) mice display massive liver damage with multifocal inflammation and fibrogenesis. The bioinformatics analysis of the microarray gene-expression datasets of ADAR1 KO livers reveled a type-I interferons signature and an enrichment for immune response genes compared to control littermate livers. Furthermore, we found that in vitro silencing of ADAR1 expression in HepG2 cells leads to enhanced transcription of NFκB target genes, foremost of the pro-inflammatory cytokines IL6 and IL8. We also discovered immune cell-independent paracrine signaling among ADAR1-depleted HepG2 cells and hepatic stellate cells, leading to the activation of the latter cell type to adopt a profibrogenic phenotype. This paracrine communication dependent mainly on the production and secretion of the cytokine IL6 induced by ADAR1 silencing in hepatocytes. Thus, our findings shed a new light on the vital regulatory role of ADAR1 in hepatic immune homeostasis, chiefly its inhibitory function on the crosstalk between the NFκB and type-I interferons signaling cascades, restraining the development of liver inflammation and fibrosis.
ADAR1 deletion induces NFκB and interferon signaling dependent liver inflammation and fibrosis
Creators: name: Ben-Shoshan, Shirley Oren
name: Kagan, Polina
name: Sultan, Maya
name: Barabash, Zohar
name: Dor, Chen
name: Jacob-Hirsch, Jasmine
name: Harmelin, Alon
name: Pappo, Orit
name: Marcu-Malina, Victoria
name: Ben-Ari, Ziv
name: Amariglio, Ninette
name: Rechavi, Gideon
name: Goldstein, Itamar
name: Safran, Michal
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Adenosine deaminase acting on RNA (ADAR) 1 binds and edits double-stranded (ds) RNA secondary structures found mainly within untranslated regions of many transcripts. In the current research, our aim was to study the role of ADAR1 in liver homeostasis. As previous studies show a conserved immunoregulatory function for ADAR1 in mammalians, we focused on its role in preventing chronic hepatic inflammation and the associated activation of hepatic stellate cells to produce extracellular matrix and promote fibrosis. We show that hepatocytes specific ADAR1 knock out (KO) mice display massive liver damage with multifocal inflammation and fibrogenesis. The bioinformatics analysis of the microarray gene-expression datasets of ADAR1 KO livers reveled a type-I interferons signature and an enrichment for immune response genes compared to control littermate livers. Furthermore, we found that in vitro silencing of ADAR1 expression in HepG2 cells leads to enhanced transcription of NFκB target genes, foremost of the pro-inflammatory cytokines IL6 and IL8. We also discovered immune cell-independent paracrine signaling among ADAR1-depleted HepG2 cells and hepatic stellate cells, leading to the activation of the latter cell type to adopt a profibrogenic phenotype. This paracrine communication dependent mainly on the production and secretion of the cytokine IL6 induced by ADAR1 silencing in hepatocytes. Thus, our findings shed a new light on the vital regulatory role of ADAR1 in hepatic immune homeostasis, chiefly its inhibitory function on the crosstalk between the NFκB and type-I interferons signaling cascades, restraining the development of liver inflammation and fibrosis.
Anatomy of molecular properties evaluated with explicitly correlated electronic wave functions
Creators: name: Jinmei Zhang
name: Calvin, Justus A.
name: Valeev, Edward F.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Plant Biology

description: Static electric dipole and quadrupole moments were evaluated at the explicitly correlated second-order Møller–Plesset (MP2-F12) level for BH, CO, H2O, and HF molecules. The electron correlation contributions to the multipole moments were further decomposed into the direct (unrelaxed) and indirect (orbital response) components; we found that both components are equally important for the conventional (MP2) contribution, whereas the F12 correction to these properties originates primarily from the orbital response effects. Finally, the direct contribution dominates in the perturbative Hartree–Fock basis set incompleteness (CABS singles) correction. Two basis set families were employed: the standard aug-cc-pVXZ series and the cc-pVXZ-F12 series designed specifically for the F12 methods. The aug-cc-pVXZ MP2-F12 multipole moments usually have smaller basis set errors than the cc-pVXZ-F12 counterparts, albeit their differences are small at the triple (X = T) and quadruple (X = Q) zeta level. With the MP2-F12 calculations, the basis set errors of dipole and quadrupole moments can be reduced to ∼0.001 a.u., or roughly 0.1%, at the aug-cc-pVDZ and aug-cc-pVTZ levels, respectively.
Impact of hypoglycemic events and HbA1c level on sulfonylurea discontinuation and down-titration
Creators: name: Laires, Pedro A.
name: Tang, Jackson
name: Fan, Chun Po Steve
name: Zhiyi Li
name: Qiu, Ying
name: Iglay, Kristy
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: Plant Biology
subject: 60506 Virology

description: Background: A retrospective cohort study using GE Centricity electronic medical records assessed the association between post-index hypoglycemia and HbA1c with discontinuation and down-titration of sulfonylureas among patients with Type 2 diabetes mellitus. Methods: Adult patients with an index prescription for a sulfonylurea and ≥12 months’ continuous records pre- and post-index were eligible. Sulfonylurea discontinuation and down-titration was assessed 1-year post-index. Discontinuation occurred if the date of a prescription was >90 days from the preceding prescription plus days of supply. Down-titration occurred when a subsequent prescription was lower than the index dose. Cox regression assessed the association between post-index hypoglycemia and HbA1c with time to sulfonylurea discontinuation and down-titration, as well as other factors. Results: 28,371 participants were included in the study; 13,459 (47.4%) were discontinuers, 717 (2.5%) were down-titraters, and 14,195 (50.0%) were continuers. 0.6% of continuers experienced hypoglycemia 1-year post-index, compared with 3.1% of down-titraters and 0.8% of discontinuers (p nd generation sulfonylureas had an increased rate of discontinuation (HR = 1.05, 95% CI: 1.04–1.06; HR = 1.19, 95% CI: 1.14–1.24, respectively). Conclusion: Approximately half of participants who initiated sulfonylureas discontinued or down-titrated therapy within one year. Both post-index hypoglycemia and higher HbA1c were significant risk factors for sulfonylurea treatment change.
Additional file 1 of Significance of levothyroxine treatment on serum lipid in pregnant women with subclinical hypothyroidism
Creators: name: Yang, Yuxi
name: Yuan, Huabing
name: Wang, Xueran
name: Zhang, Zheng
name: Liu, Ruixia
name: Yin, Chenghong
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Hematology

description: Additional file 1: Table S1. Multivariate logistic regression among different BMI groups.
Distribution properties for t-hooks in partitions
Creators: name: Craig, William
name: Pun, Anna
Publisher: name: arXiv
Year: 2020
Subjects: subject: Number Theory (math.NT)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: Partitions, the partition function $p(n)$, and the hook lengths of their Ferrers-Young diagrams are important objects in combinatorics, number theory and representation theory. For positive integers $n$ and $t$, we study $p_t^e(n)$ (resp. $p_t^o(n)$), the number of partitions of $n$ with an even (resp. odd) number of $t$-hooks. We study the limiting behavior of the ratio $p_t^e(n)/p(n)$, which also gives $p_t^o(n)/p(n)$ since $p_t^e(n) + p_t^0(n) = p(n)$. For even $t$, we show that $$\lim\limits_{n \to \infty} \dfrac{p_t^e(n)}{p(n)} = \dfrac{1}{2},$$ and for odd $t$ we establish the non-uniform distribution $$\lim\limits_{n \to \infty} \dfrac{p^e_t(n)}{p(n)} = \begin{cases} \dfrac{1}{2} + \dfrac{1}{2^{(t+1)/2}} & \text{if } 2 \mid n, \\ \\ \dfrac{1}{2} - \dfrac{1}{2^{(t+1)/2}} & \text{otherwise.} \end{cases}$$ Using the Rademacher circle method, we find an exact formula for $p_t^e(n)$ and $p_t^o(n)$, and this exact formula yields these distribution properties for large $n$. We also show that for sufficiently large $n$, the signs of $p_t^e(n) - p_t^o(n)$ are periodic.
Social Welfare in Search Games with Asymmetric Information
Creators: name: Bavly, Gilad
name: Heller, Yuval
name: Schreiber, Amnon
Publisher: name: arXiv
Year: 2020
Subjects: subject: Theoretical Economics (econ.TH)
subject: FOS: Economics and business

description: We consider games in which players search for a hidden prize, and they have asymmetric information about the prize location. We study the social payoff in equilibria of these games. We present sufficient conditions for the existence of an equilibrium that yields the first-best payoff (i.e., the highest social payoff under any strategy profile), and we characterize the first-best payoff. The results have interesting implications for innovation contests and R&D races.
description: 34 pages main text (including 9 figures) + 14 pages of appendices + bibliography
Additional file 1 of Regeneration of meniscal avascular zone using autogenous meniscal fragments in a rabbit model
Creators: name: Deng, Yan
name: Tong, Zuo-Ming
name: Dai, Zhu
name: Chen, Zhi-Wei
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: Developmental Biology
subject: Cancer

description: Additional file 1: Figure S1. The details of the defect model.
Regio- and stereoselective co-iodination of olefins using NH4I and Oxone
Creators: name: Chevella Durgaiah
name: Mameda Naresh
name: Macharla Arun Kumar
name: Peraka Swamy
name: Marri Mahender Reddy
name: Kodumuri Srujana
name: Nama Narender
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: A simple, efficient, and environmentally benign protocol for the synthesis of vicinal iodohydrins and iodoesters from olefins using NH4I and Oxone in CH3CN/H2O (1:1) and dimethylformamide (DMF) / dimethylacetamide (DMA), respectively, without employing a catalyst at room temperature is described. Regio- and stereoselective iodohydroxylation and iodoesterification of various olefins with anti fashion, following Markonikov’s rule, was achieved and the corresponding products were obtained in good to excellent yields. In addition, 1,2-disubstituted olefins afforded excellent diastereoselectivity.
Arrêt du parlement, qui permet aux Avocats résidents à Douay de se former en Communauté et qui en règle les conditions
Creators: name: Plouvain, Pierre-Antoine-Samuel-Joseph (1754-1832)
name: Six, Philippe-Josse-Auguste-Joseph (1732-1793)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2019
Subjects: Organisation professionnelle
Avocat

description: Source: http://nordnum.univ-lille.fr/ark:/72505/a0115224001360im5Ol/from/a011522400136ypxWl2
description: Source: NAKALONA
description: Coverage: Parlement de Flandre
description: issued: 14/02/2019
Linker flexibility of IVS3-S4 loops modulates voltage-dependent activation of L-type Ca2+ channels
Creators: name: Liu, Nan
name: Yuxia Liu
name: Yaxiong Yang
name: Xiaodong Liu
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Extracellular S3-S4 linkers of domain IV (IVS3-S4) of L-type Ca2+ channels (CaV1) are subject to alternative splicing, resulting into distinct gating profiles serving for diverse physiological roles. However, it has remained elusive what would be the determining factor of IVS3-S4 effects on CaV1 channels. In this study, we systematically compared IVS3-S4 variants from CaV1.1-1.4, and discover that the flexibility of the linker plays a prominent role in gating characteristics. Chimeric analysis and mutagenesis demonstrated that changes in half activation voltage (V1/2) or activation time constant (τ) are positively correlated with the numbers of flexible glycine residues within the linker. Moreover, antibodies that reduce IVS3-S4 flexibility negatively shifted V1/2, emerging as a new category of CaV1 enhancers. In summary, our results suggest that the flexibility or rigidity of IVS3-S4 linker underlies its modulations on CaV1 activation (V1/2 and τ), paving the way to dissect the core mechanisms and to develop innovative perturbations pertaining to voltage-sensing S4 and its vicinities.
Effects of focal brain damage on political behaviour across different political ideologies
Creators: name: Siddiqi, Shan
Publisher: name: Zenodo
Year: 2025

description: This MATLAB function performs leave-one-out cross-validation (LOOCV) for a lesion network mapping analysis. It assesses whether each subject’s lesion connectivity map aligns with the group-level lesion-behavior association, predicting behavioral outcomes such as political involvement.
Unraveling the topology of dissipative quantum systems
Creators: name: Gneiting, Clemens
name: Koottandavida, Akshay
name: Rozhkov, Alexander V.
name: Nori, Franco
Publisher: name: arXiv
Year: 2020
Subjects: subject: Quantum Physics (quant-ph)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: We discuss topology in dissipative quantum systems from the perspective of quantum trajectories. The latter emerge in the unraveling of Markovian quantum master equations and/or in continuous quantum measurements. Ensemble-averaging quantum trajectories at the occurrence of quantum jumps, i.e., the jump times, gives rise to a discrete, deterministic evolution which is highly sensitive to the presence of dark states. We show for a broad family of translation-invariant collapse models that the set of dark state-inducing Hamiltonians imposes a nontrivial topological structure on the space of Hamiltonians, which is also reflected by the corresponding jumptime dynamics. The topological character of the latter can then be observed, for instance, in the transport behavior, exposing an infinite hierarchy of topological phase transitions. We develop our theory for one- and two-dimensional two-band Hamiltonians and show that the topological behavior is directly manifest for chiral, PT, or time reversal-symmetric Hamiltonians.
description: Corresponds to published version. 15 pages
MHSA-Net: Multi-Head Self-Attention Network for Occluded Person Re-Identification
Creators: name: Tan, Hongchen
name: Liu, Xiuping
name: Yin, Baocai
name: Li, Xin
Publisher: name: arXiv
Year: 2020
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: This paper presents a novel person re-identification model, named Multi-Head Self-Attention Network (MHSA-Net), to prune unimportant information and capture key local information from person images. MHSA-Net contains two main novel components: Multi-Head Self-Attention Branch (MHSAB) and Attention Competition Mechanism (ACM). The MHSAB adaptively captures key local person information, and then produces effective diversity embeddings of an image for the person matching. The ACM further helps filter out attention noise and non-key information. Through extensive ablation studies, we verified that the Multi-Head Self-Attention Branch (MHSAB) and Attention Competition Mechanism (ACM) both contribute to the performance improvement of the MHSA-Net. Our MHSA-Net achieves competitive performance in the standard and occluded person Re-ID tasks.
description: Accepted by TNNLS
Synthesis and spectral properties of novel iminophosphoranes
Creators: name: Fang, Jing-Kun
name: Zhimin Xu
name: Tengxiao Sun
name: Fang, Yu
name: Zhengxi Yin
name: Shijun Wang
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: Inorganic Chemistry

description: Three new iminophosphoranes coded as FPZ1 (Ph–C≡C–C6H4–N = PPh3), FPZ2 (Ph–N = P(C6H4–C≡C–Ph)3) and FPZ3 (Ph–C≡C–C6H4–N = P(C6H4–C≡C–Ph)3) were designed and synthesized by introducing different numbers of phenylene acetylene units to FPZ0 (Ph–N = PPh3). The effect of structural modification was studied in detail analyzing the absorption spectra, the emission spectra, and the distributions of the electron density. The absorption spectra of the new iminophosphoranes are shown to be a linear combination of the spectra of each part by the artificial combinatorial absorption spectrum, which coincides with the real one. Most probably the individual parts can’t conjugate due to the tetrahedral structure. The probably formed excimer of FPZ0 and FPZ1 causes in their solid emission spectra an obvious bathochromic shift as compared to that of FPZ2 and FPZ3. The melting point data also showed that long branches of FPZ2 and FPZ3 will attenuate the interactions between the molecules. The results of quantum chemical calculations show that the electronic density in the HOMO of FPZ1, FPZ2, and FPZ3 is delocalized over the iminoaryl moieties. The electron density in the LUMO is delocalized over the triaryl phosphine moieties, but only concentrated on two branches, which directly determines the main direction of intramolecular charge transfer.
Cultural Heritage Pilot (E-RIHS): Immersive Spatial Environment and Illuminated Manuscripts HUB - H2IOSC General Meeting
Creators: name: Zecca, Davide
Publisher: name: Zenodo
Year: 2024

description: The presentation describes the progress about the activity 7.5 "Cultural Heritage Pilot (E-RIHS): Immersive Spatial Environment and Illuminated Manuscripts HUB" (WP7) whithin the Humanities and cultural Heritage italian Open Science Cloud (H2IOSC) a PNRR project funded by the European Union under the NextGenerationEU.
Additional file 2 of Procedural analgesic interventions in China: a national survey of 2198 hospitals
Creators: name: Wang, Yafeng
name: Xu, Feng
name: Zhao, Shuai
name: Han, Linlin
name: Huang, Shiqian
name: Zhu, Hongyu
name: Ding, Yuanyuan
name: Ma, Lulin
name: Zhao, Wenjing
name: Zhang, Tianhao
name: Chen, Xiangdong
Publisher: name: figshare
Year: 2022
Subjects: Medicine
Science Policy

description: Additional file 2.