title: Ð­ÐºÑÐ¿ÑÐµÑÑÐ¸Ñ Ð³ÐµÐ½Ð¾Ð² Ð¾Ð¼ÐµÐ½ÑÐ¸Ð½Ð°-1 Ð¸ ÑÑÐ°Ð½ÑÐºÑÐ¸Ð¿ÑÐ¸Ð¾Ð½Ð½Ð¾Ð³Ð¾ ÑÐ°ÐºÑÐ¾ÑÐ° PPARÎ³ Ð² ÑÐ¿Ð¸ÐºÐ°ÑÐ´Ð¸Ð°Ð»ÑÐ½Ð¾Ð¹ Ð¸ Ð¿Ð¾Ð´ÐºÐ¾Ð¶Ð½Ð¾Ð¹ Ð¶Ð¸ÑÐ¾Ð²Ð¾Ð¹ ÑÐºÐ°Ð½Ð¸ Ñ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ñ Ð¸ÑÐµÐ¼Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð±Ð¾Ð»ÐµÐ·Ð½ÑÑ ÑÐµÑÐ´ÑÐ°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Gene expression of omentin-1 and transcription factor PPARÎ³ in epicardial and subcutaneous adipose tissue in patients with coronary artery disease
Creators: name: ÐÑÐ°ÑÐµÐ²Ð°, ÐÑÐµÐ½Ð¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: Ð°Ð±Ð´Ð¾Ð¼Ð¸Ð½Ð°Ð»ÑÐ½Ð¾Ðµ Ð¾Ð¶Ð¸ÑÐµÐ½Ð¸Ðµ
Ð°Ð´Ð¸Ð¿Ð¾ÐºÐ¸Ð½Ñ
Ð¸ÑÐµÐ¼Ð¸ÑÐµÑÐºÐ°Ñ Ð±Ð¾Ð»ÐµÐ·Ð½Ñ ÑÐµÑÐ´ÑÐ°
Ð¾Ð¼ÐµÐ½ÑÐ¸Ð½-1
Ð¿Ð¾Ð´ÐºÐ¾Ð¶Ð½Ð°Ñ Ð¶Ð¸ÑÐ¾Ð²Ð°Ñ ÑÐºÐ°Ð½Ñ (ÐÐÐ¢)
ÑÐ¿Ð¸ÐºÐ°ÑÐ´Ð¸Ð°Ð»ÑÐ½Ð°Ñ Ð¶Ð¸ÑÐ¾Ð²Ð°Ñ ÑÐºÐ°Ð½Ñ (Ð­ÐÐ¢)
PPARÎ³
abdominal obesity
adipokines
coronary artery disease
epicardial adipose tissue (EAT)
omentin-1
subcutaneous adipose tissue (SAT)

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±ÑÐ»Ð° Ð²ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð° Ð½Ð° Ð±Ð°Ð·Ðµ Ð»Ð°Ð±Ð¾ÑÐ°ÑÐ¾ÑÐ¸Ð¸ Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½Ð¾Ð¹ Ð³ÐµÐ½ÐµÑÐ¸ÐºÐ¸ ÑÐµÐ»Ð¾Ð²ÐµÐºÐ° ÐÐÐ¦ Â«ÐÑÑÑÐ°ÑÐ¾Ð²ÑÐºÐ¸Ð¹ Ð¸Ð½ÑÑÐ¸ÑÑÑÂ» - ÐÐÐ¯Ð¤ Ð¸ Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ Ð°ÑÑÐ¾ÑÐ¸Ð°ÑÐ¸Ð¸ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð³ÐµÐ½Ð¾Ð² Ð¾Ð¼ÐµÐ½ÑÐ¸Ð½Ð°-1 (ITLN1) Ð¸ ÑÑÐ°Ð½ÑÐºÑÐ¸Ð¿ÑÐ¸Ð¾Ð½Ð½Ð¾Ð³Ð¾ ÑÐ°ÐºÑÐ¾ÑÐ° PPARÎ³ (PPARG) Ð² Ð­ÐÐ¢ Ð¸ ÐÐÐ¢ Ñ ÑÐ°Ð·Ð²Ð¸ÑÐ¸ÐµÐ¼ Ð¸ÑÐµÐ¼Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð±Ð¾Ð»ÐµÐ·Ð½Ð¸ ÑÐµÑÐ´ÑÐ° (ÐÐÐ¡), Ð² ÑÐ¾Ð¼ ÑÐ¸ÑÐ»Ðµ Ð¿ÑÐ¸ Ð¾Ð¶Ð¸ÑÐµÐ½Ð¸Ð¸. ÐÑÐ»Ð¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ñ Ð¾Ð±ÑÐ°Ð·ÑÑ Ð­ÐÐ¢, ÐÐÐ¢ 74 Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ñ ÐÐÐ¡ Ð¸ 16 Ð»Ð¸Ñ Ð³ÑÑÐ¿Ð¿Ñ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ñ. OÑeÐ½Ðºa ÑÑoÐ²Ð½Ñ Ð¼Ð ÐÐ Ð¿ÑoÐ²oÐ´Ð¸Ð»aÑÑ Ð¼eÑoÐ´oÐ¼ ÐÐ¦Ð  Ð² peÐ¶Ð¸Ð¼e peÐ°Ð»ÑÐ½oÐ³o Ð²ÑÐµÐ¼ÐµÐ½Ð¸. OÐ¿ÑeÐ´eÐ»eÐ½Ð¸e ÑÑoÐ²Ð½Ñ Ð±eÐ»Ðºa Ð²ÑÐ¿oÐ»Ð½ÑÐ»oÑÑ Ð¼eÑoÐ´oÐ¼ Ð²eÑÑepÐ½-Ð±Ð»oÑ. ÐÐ»Ñ ÑÐ¸Ð¿Ð¸ÑoÐ²Ð°Ð½Ð¸Ñ Ð¿oÐ»Ð¸Ð¼oÑÑÐ½ÑÑ Ð²aÑÐ¸aÐ½ÑoÐ² Pro12Ala Ð³ÐµÐ½Ð° PPARG Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½ Ð¼ÐµÑÐ¾Ð´ ÐÐ¦Ð  Ñ Ð¿Ð¾ÑÐ»ÐµÐ´ÑÑÑÐ¸Ð¼ ÑÐµÑÑÑÐ¸ÐºÑÐ¸Ð¾Ð½Ð½ÑÐ¼ Ð°Ð½Ð°Ð»Ð¸Ð·Ð¾Ð¼. Ð£ÑoÐ²eÐ½Ñ Ð¼Ð ÐÐ Ð³eÐ½Ð° PPARG Ð² ÐÐÐ¢ Ð±ÑÐ» Ð½Ð¸Ð¶Ðµ Ñ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ñ ÐÐÐ¡, Ð¸ Ð¾ÑÑÐ¸ÑÐ°ÑÐµÐ»ÑÐ½Ð¾ ÐºÐ¾ÑÑÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð» Ñ Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÐ°Ð¼Ð¸ Ð¾ÐºÑÑÐ¶Ð½Ð¾ÑÑÐ¸ ÑÐ°Ð»Ð¸Ð¸ Ð¸ Ð¸Ð½Ð´ÐµÐºÑÐ° Ð¼Ð°ÑÑÑ ÑÐµÐ»Ð° (ÐÐÐ¢), Ð¿Ð¾Ð»Ð¾Ð¶Ð¸ÑÐµÐ»ÑÐ½Ð¾ â Ñ ÐºÐ¾Ð½ÑÐµÐ½ÑÑÐ°ÑÐ¸ÐµÐ¹ Ð¾Ð¼ÐµÐ½ÑÐ¸Ð½Ð°-1 Ð² ÑÑÐ²Ð¾ÑÐ¾ÑÐºÐµ ÐºÑÐ¾Ð²Ð¸. ÐÑÐ»Ð° Ð²ÑÑÐ²Ð»ÐµÐ½Ð° Ð¾ÑÑÐ¸ÑÐ°ÑÐµÐ»ÑÐ½Ð°Ñ ÐºÐ¾ÑÑÐµÐ»ÑÑÐ¸Ñ ÑÑÐ¾Ð²Ð½Ñ Ð¼Ð ÐÐ Ð³ÐµÐ½Ð° PPARG Ñ ÑÑÐ¾Ð²Ð½ÐµÐ¼ Ð¼Ð ÐÐ Ð³ÐµÐ½Ð° ITLN1 Ð¸ Ð±ÐµÐ»ÐºÐ° Ð¾Ð¼ÐµÐ½ÑÐ¸Ð½Ð°-1 Ð² ÐÐÐ¢. ÐÑÐ½Ð¾ÑÐ¸ÑÐµÐ»ÑÐ½ÑÐ¹ ÑÑÐ¾Ð²ÐµÐ½Ñ Ð±ÐµÐ»ÐºÐ° Ð¾Ð¼ÐµÐ½ÑÐ¸Ð½Ð°-1 Ð² ÐÐÐ¢ Ð±ÑÐ» ÑÐ½Ð¸Ð¶ÐµÐ½ Ð² Ð¿Ð¾Ð´Ð³ÑÑÐ¿Ð¿Ðµ Ð»Ð¸Ñ Ð¸Ð· Ð³ÑÑÐ¿Ð¿Ñ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ñ, ÑÑÑÐ°Ð´Ð°ÑÑÐ¸Ñ Ð°Ð±Ð´Ð¾Ð¼Ð¸Ð½Ð°Ð»ÑÐ½ÑÐ¼ Ð¾Ð¶Ð¸ÑÐµÐ½Ð¸ÐµÐ¼. ÐÑÐ½Ð¾ÑÐ¸ÑÐµÐ»ÑÐ½ÑÐ¹ ÑÑÐ¾Ð²ÐµÐ½Ñ Ð±ÐµÐ»ÐºÐ° Ð¾Ð¼ÐµÐ½ÑÐ¸Ð½Ð°-1 Ð² Ð­ÐÐ¢ Ð±ÑÐ» Ð²ÑÑÐµ Ñ Ð¾Ð±ÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð½ÑÑ Ð»Ð¸Ñ Ñ Ð½Ð¾ÑÐ¼Ð°Ð»ÑÐ½Ð¾Ð¹ Ð¼Ð°ÑÑÐ¾Ð¹ ÑÐµÐ»Ð° (ÐÐÐ¢ &lt; 25) Ð½ÐµÐ·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ Ð¾Ñ Ð½Ð°Ð»Ð¸ÑÐ¸Ñ Ñ Ð½Ð¸Ñ ÐÐÐ¡.
description: This work had been carried out on the basis of the Laboratory of Human Molecular Genetics of NRC Â«Kurchatov InstituteÂ» - PNPI and concentrated on the study of the association of the expression of the omentin-1 (ITLN1) and the transcription factor PPARÎ³ (PPARG) genes in EÐÐ¢ and SAT with the development of coronary artery disease (CAD) and concomitant obesity. EAT and SAT samples were studied in 74 patients with CAD and 16 individuals in the control group. The mRNA level was estimated by real-time PCR. Protein level determination was performed using the Western blot. The PCR followed with restriction analysis was used for identification of polymorphic variants Pro12Ala in PPARG gene. The SAT PPARG mRNA level was reduced in patients with CAD, and negatively correlated with waist circumference and body mass index, positively â with serum omentin-1 level. A negative correlation was identified between the PPARG gene mRNA level and omentin-1 mRNA and protein levels in SAT. Omentin-1 protein level in SAT was reduced in a subgroup of control subjects suffering from abdominal obesity. Omentin-1 protein level in EAT was increased in individuals with normal body weight (body mass index &lt; 25) regardless of the presence of CAD.