cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Loss of transferrin receptor activity in Neisseria meningitidis correlates with inability to use transferrin as an iron source.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1988

description: Although Neisseria meningitidis does not produce siderophores, it is able to obtain iron from human transferrin. We observed saturable specific binding of 125I-labeled human transferrin to meningococci. Human lactoferrin and mouse transferrin did not compete with human transferrin for binding, whereas human apotransferrin and 100% iron-saturated transferrin competed equally well. Meningococci thus have a specific receptor for human transferrin. Scatchard analysis yielded a relatively low Kd of 0.7 microM and an apparent copy number of 2,900 receptors per CFU. Receptor activity was iron-regulated. A meningococcal transformant specifically unable to utilize transferrin as an iron source had decreased transferrin receptor activity. These data are consistent with the hypothesis that receptor-mediated binding of transferrin is a rate-limiting step in meningococcal iron uptake from transferrin.
Mouse genetic locus Lps influences susceptibility to Neisseria meningitidis infection.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1988

description: We surveyed a number of inbred mouse strains for susceptibility to meningococcemia. Mice of all strains became bacteremic after intraperitoneal injection of a serogroup C, serotype 2a human disease isolate, but the strains differed in levels of bacteremia, indicating influences of the host genome on susceptibility. There was no significant correlation between level of bacteremia and differences at major histocompatibility or immunoglobulin loci; the Salmonella susceptibility locus, Ity; the complement C5 locus, Hc; the antibody response locus, xid; or the transferrin locus, Trf. However, the Lps locus, which influences a range of host cellular responses to endotoxin and affects susceptibility to Salmonella typhimurium, did influence susceptibility to meningococcemia. There were significant differences in levels of bacteremia between C3H/HeJ (Lpsd) mice and each of the other strains (all Lpsn). We confirmed the association of the Lpsd genotype with susceptibility by using coisogenic strains from two widely separated mouse lineages: C3H and B10. Lpsd mice experienced a 1,000-fold proliferation of bacteria and were bacteremic for days before clearing the infection. In contrast, Lpsn mice cleared the bacteremia in less than 1 day. There was no difference in meningococcal growth in vitro in serum from C3H/HeJ and coisogenic C3H/HeN (Lpsn) mice, suggesting that the Lps-related difference in susceptibility may involve a cellular response.
Extensions of the Duflo map and Chern-Simons expectation values
Creators: name: Sahlmann, Hanno
name: Zilker, Thomas
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The Duflo map is a valuable tool for operator ordering in contexts in which Kirillov-Kostant brackets and their quantizations play a role. A priori, the Duflo map is only defined on the subspace of the symmetric algebra over a Lie algebra consisting of elements invariant under the adjoint action. Here we discuss extensions to the whole symmetric algebra, as well as their application to the calculation of Chern-Simons theory expectation values.
description: 22 pages, 2 figures, matches published version
Reversible phase variation of expression of Neisseria meningitidis class 5 outer membrane proteins and their relationship to gonococcal proteins II.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1988

description: Neisseria meningitidis class 5 proteins are major outer membrane proteins that share many properties with the proteins II (P.II) of Neisseria gonorrhoeae. We generated two bactericidal monoclonal antibodies, each of which bound specifically to one of the two identified class 5 proteins produced by N. meningitidis FAM18. The monoclonal antibodies also bound to class 5 proteins of a limited number of other meningococcal strains. Using the bactericidal activity of the monoclonal antibodies, we demonstrated that expression of both class 5 proteins was subject to reversible phase variation in vitro. The N-terminal amino acid sequence of a purified class 5 protein revealed striking similarity to the N-terminal amino acid sequence of gonococcal P.II proteins. Using a cloned class 5 gene, we identified three potential class 5 gene loci in N. meningitidis FAM18. These class 5 sequences also had homology with gonococcal P.II gene sequences and contained the CTCTT repeat sequence believed to be important in the regulation of gonococcal P.II expression.
On the generalized Nash problem for smooth germs and adjacencies of curve singularities
Creators: name: de Bobadilla, Javier Fernandez
name: Pereira, Maria Pe
name: Popescu-Pampu, Patrick
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Geometry (math.AG)
subject: Complex Variables (math.CV)
subject: FOS: Mathematics

description: In this paper we explore the generalized Nash problem for arcs on a germ of smooth surface: given two prime divisors above its special point, to determine whether the arc space of one of them is included in the arc space of the other one. We prove that this problem is combinatorial and we explore its relation with several notions of adjacency of plane curve singularities.
description: Final version
Three-dimensional purely quasi-monomial actions
Creators: name: Hoshi, Akinari
name: Kitayama, Hidetaka
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Geometry (math.AG)
subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 12F20, 13A50, 14E08

description: Let $G$ be a finite subgroup of $\mathrm{Aut}_k(K(x_1, \ldots, x_n))$ where $K/k$ is a finite field extension and $K(x_1,\ldots,x_n)$ is the rational function field with $n$ variables over $K$. The action of $G$ on $K(x_1, \ldots, x_n)$ is called quasi-monomial if it satisfies the following three conditions (i) $σ(K)\subset K$ for any $σ\in G$; (ii) $K^G=k$ where $K^G$ is the fixed field under the action of $G$; (iii) for any $σ\in G$ and $1 \leq j \leq n$, $σ(x_j)=c_j(σ)\prod_{i=1}^n x_i^{a_{ij}}$ where $c_j(σ)\in K^\times$ and $[a_{i,j}]_{1\le i,j \le n} \in GL_n(\mathbb{Z})$. A quasi-monomial action is called purely quasi-monomial if $c_j(σ)=1$ for any $σ\in G$, any $1\le j\le n$. When $k=K$, a quasi-monomial action is called monomial. The main problem is that, under what situations, $K(x_1,\ldots,x_n)^G$ is rational (= purely transcendental) over $k$. For $n=1$, the rationality problem was solved by Hoshi, Kang and Kitayama. For $n=2$, the problem was solved by Hajja when the action is monomial, by Voskresenskii when the action is faithful on $K$ and purely quasi-monomial, which is equivalent to the rationality problem of $n$-dimensional algebraic $k$-tori which split over $K$, and by Hoshi, Kang and Kitayama when the action is purely quasi-monomial. For $n=3$, the problem was solved by Hajja, Kang, Hoshi and Rikuna when the action is purely monomial, by Hoshi, Kitayama and Yamasaki when the action is monomial except for one case and by Kunyavskii when the action is faithful on $K$ and purely quasi-monomial. In this paper, we determine the rationality when $n=3$ and the action is purely quasi-monomial except for few cases. As an application, we will show the rationality of some $5$-dimensional purely monomial actions which are decomposable.
description: To appear in Kyoto J. Math., 34 pages. arXiv admin note: text overlap with arXiv:1201.1332
A hierarchical cluster analysis of the psycological impact of the COVID-19 pandemic on Italian severe asthma patients
Creators: name: Guarnieri, G.
name: Chiurato, L.
name: Baiardini, I.
name: Caminati, M.
name: Senna, G.
name: Scarpa, B.
name: Vianello, A.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: In the context of COVID-19 pandemic, a consistent medical concern raised among severe asthma patients, though the studies excluded an increased risk of severe disease as well as an increased susceptibility. The aim of the study was to apply the Psychological General Well-Being Index (PGWBI) questionnaire to severe asthmatics during the COVID-19 pandemic and to evaluate the data with a hierarchical cluster analysis. 114 severe asthmatics were asked to respond anonymously to the PGWBI questionnaire. The patients underwent a lung functional test, fractional exhaled nitric oxide (FeNO) measurement, Asthma Control Test (ACT), and Asthma Control Questionnaire (ACQ6). A hierarchical cluster analysis was performed using an agglomerative approach and complete linkage to evaluate the results. The study population predominantly included female (60%), middle-aged patients, with normal lung function parameters, mild signs of airway, and satisfactory asthma control. The PGWBI score (82.46 ± 16.53) of the study population showed a good state of psychological well-being and was similar to that of a representative sample of healthy adult Italian subjects. Thus, Hierarchical cluster analysis identified 3 groups of patients: Cluster 1 (32%), Cluster 2 (64%), and Cluster 3 (4%). Whilst the Cluster 2 patients’ PGWBI score fell within the normal range, the Cluster 1 patients had a significantly lower total score (68.57 ± 7.2; p < 0.05), suggesting moderate distress. The Cluster 3 patients presented a total score markedly low. Although the majority of the severe asthma patients studied demonstrated good mental well-being during the COVID-19 pandemic, some did indeed show moderate to severe psychological distress.
Systemic uptake and intestinal inflammatory effects of luminal bacterial cell wall polymers in rats with acute colonic injury.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1988

description: The systemic uptake and local intestinal inflammatory potential of luminal bacterial cell wall polymers in rats with normal and acutely inflamed colons were measured. Rats were injected intracecally with either 125I-labeled group A streptococcal peptidoglycan-polysaccharide complexes or equal amounts of Na125I, after either nonspecific colonic injury with 4% acetic acid or injection with buffer. The colons of rats injected with peptidoglycan-polysaccharide had higher inflammatory scores than Na125I-injected rats, a greater incidence of mucosal ulceration and transmural inflammation after acetic acid injury, and an increased frequency of focal accumulations of inflammatory cells in the lamina propria and submucosa after buffer injection. Radioactivity in the liver, spleen, and mesenteric lymph nodes was higher in the colon-injured rats that received peptidoglycan-polysaccharide 48 h before tissue collection than in the noninjured rats (P less than 0.002). Group A streptococcal polysaccharide antigen concentration within the liver, spleen, and mesenteric lymph nodes, measured by enzyme-linked immunosorbent assay, was significantly higher in the colon-injured rats that received cell wall polymers than in noninjured rats. These results indicate that luminal bacterial cell wall polymers with well-described inflammatory and immunoregulatory potential can cross injured colonic epithelia and are capable of initiating and potentiating intestinal inflammation.
Which geodesic flows are left-handed ?
Creators: name: Dehornoy, Pierre
Publisher: name: arXiv
Year: 2015
Subjects: subject: Geometric Topology (math.GT)
subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: We prove that the geodesic flow on the unit tangent bundle to a hyperbolic 2-orbifold is left-handed if and only if the orbifold is a sphere with three conic points. As a consequence, on the unit tangent bundle to a 3-conic sphere, the lift of every finite collection of closed geodesics that is zero in integral homology is the binding of an open book decomposition.
Homogeneous quasi-translations in dimension 5
Creators: name: de Bondt, Michiel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14R05, 14R10, 14R20

description: We give a proof in modern language of the following result by Paul Gordan and Max Nöther: a homogeneous quasi-translation in dimension $5$ without linear invariants would be linearly conjugate to another such quasi-translation $x + H$, for which $H_5$ is algebraically independent over $\mathbb C$ of $H_1, H_2, H_3, H_4$. Just like Gordan and Nöther, we apply this result to classify all homogeneous polynomials $h$ in $5$ indeterminates from which the Hessian determinant is zero. Others claim to have reproved 'the result of Gordan and Nöther in $\mathbb P^4$' as well, but some of them assume that $h$ is irreducible, which Gordan and Nöther did not. Furthermore, they do not use the above result about homogeneous quasi-translations in dimension $5$ for their classifications. (There is however one paper which could use this result very well, to fix a gap caused by an error.) We derive some other properties which $H$ would have. One of them is that ${\rm deg}\, H \ge 15$, for which we give a proof which is less computational than another proof of it by Dayan Liu. Furthermore, we show that the Zariski closure of the image of $H$ would be an irreducible component of $V(H)$, and prove that every other irreducible component of $V(H)$ would be a $3$-dimensional linear subspace of $\mathbb C^5$ which contains the fifth standard basis unit vector.
description: 34 pages
Ultrastructural study of endocytosis of Chlamydia trachomatis by McCoy cells.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1988

description: The entry of Chlamydia trachomatis into McCoy cells (fibroblasts) was studied by transmission electron microscopy. On adsorption of elementary bodies (EBs) to host cells at 37 degrees C, the EBs were bound primarily to preexisting cell-surface microvilli. They were also observed in coated pits located at the bases of the microvilli and along smooth surfaces of the host cells and were internalized within coated vesicles at this temperature. Postembedding immunogold labeling on Lowicryl thin sections with anti-clathrin antibody as the primary reagent revealed the gold marker localized in pits and vesicles containing chlamydiae. Some EBs were present in smooth-surfaced invaginations at or near the bases of microvilli and in vesicles devoid of distinguishable coat material. A similar entry process was observed with centrifugation-assisted inoculation of EBs onto the McCoy cells. Individual EBs were initially internalized into tightly bound endocytic vesicles. However, within 1 to 3 h postinfection, multiple C. trachomatis EBs were observed in large, loosely bound vesicles. Evidence suggests that vesicles containing C. trachomatis may have fused with one another early in the infectious process. These results indicate that chlamydiae can exploit the specific process of adsorptive endocytosis for entry into host cells and for translocation to a given intracellular destination, which may be different for each species.
Additional file 5 of Patterns of change in obesity indices and other cardiometabolic risk factors before the diagnosis of type 2 diabetes: two decades follow-up of the Tehran lipid and glucose study
Creators: name: Koohi, Fatemeh
name: Ahmadi, Nooshin
name: Azizi, Fereidoun
name: Khalili, Davood
name: Valizadeh, Majid
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Computational Biology

description: Additional file 5: FigureS3. Trajectories of totalcholesterol (A), low-density lipoprotein cholesterol (B), high-densitylipoprotein cholesterol (C), and the logarithm of triglycerides (D)concentrations for women of 53 years of age at time 0 and not on lipid-lowering treatment from 15 years before the diagnosis of type 2 diabetes or last examination. Lines are the estimated trajectories, and shadows are 95% CIs.
Binding sites of attachment-inhibiting monoclonal antibodies and antibodies from patients on peptide fragments of the Mycoplasma pneumoniae adhesin.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1989

description: The adherence protein (P1 protein) of Mycoplasma pneumoniae was purified by electroelution and cleaved with cyanogen bromide. The resulting peptides were separated by two-dimensional electrophoresis. Spots reacting in Western immunoblots with two attachment-inhibiting monoclonal antibodies were isolated, and the amino-terminal ends of these peptides were microsequenced. The two monoclonal antibodies had different binding sites. One was associated with the amino-terminal region of the whole P1 protein beginning at amino acid position 237, and the other was associated with amino acid position 702, which was localized approximately in the middle of the P1 amino acid sequence. Serum samples from three M. pneumoniae-infected patients were tested by Western blotting against the cyanogen bromide peptide pattern. All three serum samples reacted with peptide fragments beginning at amino acid position 702, but the serum of only one patient also had antibodies against the oligopeptides beginning at amino acid position 237. These results indicate that the corresponding epitopes of the P1 protein are also immunogenic if they are presented at the surface of the infecting organism.
Outcomes of children with life-threatening status asthmaticus requiring isoflurane therapy and extracorporeal life support
Creators: name: Kolli, Sneha
name: Opolka, Cydney
name: Westbrook, Adrianna
name: Gillespie, Scott
name: Mason, Carrie
name: Truitt, Brittany
name: Kamat, Pradip
name: Fitzpatrick, Anne
name: Grunwell, Jocelyn R.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Severe, refractory asthma is a life-threatening emergency that may be treated with isoflurane and extracorporeal life support. The objective of this study was to describe the clinical response to isoflurane and outcomes after discharge of children who received isoflurane and/or extracorporeal life-support for near-fatal asthma. This was a retrospective descriptive study using electronic medical record data from two pediatric intensive care units within a single healthcare system in Atlanta, GA. Forty-five children received isoflurane, and 14 children received extracorporeal life support, 9 without a trial of isoflurane. Hypercarbia and acidosis improved within four hours of starting isoflurane. Four children died during the index admission for asthma. Twenty-seven percent had a change in Functional Status Score of three or more points from baseline to PICU discharge. Patients had median percent predicted FEV1 and FEV1/FVC ratios pre- and post-bronchodilator values below normal pediatric values. Children who received isoflurane and/or ECLS had a high frequency of previous PICU admission and intubation. Improvement in ventilation and acidosis occurred within the first four hours of starting isoflurane. Children who required isoflurane or ECLS may develop long-lasting deficits in their functional status. Children with near-fatal asthma are a high-risk group and require improved follow-up in the year following PICU discharge.
How can we reach consensus The answer from the micro-con¯gurations of a 2-D Ising model.pdf
Creators: name: Wang, Peng
name: Ai, Hui
name: Wang, Xu-Ming
Publisher: name: figshare
Year: 2022
Subjects: subject: Applied Physics
subject: 29902 Complex Physical Systems
subject: FOS: Physical sciences

description: We study opinion formation by uncovering the relevant aspects hiding in the distribution of micro-configurations in a 2-D Ising model. The external field denotes the external inffuence such as guiding viewpoint, and temperature represents randomness of the agents. The full-positive configuration or the full-negative con figuration means consensus. We find that the probability of the full-positive configuration and the full-negative configuration can reach 0.5 (which implies the equal splitting of a group) if the interaction is strong enough and the system is free from external field; the probability of the full-positive con figuration can reach 1 (which means consensus) if the positive external field is strong enough under condition of given interaction and temperature. These phenomena are regarded as the reversing mechanism of the full-negative configuration induced by the external field ?and opinion reversal. The equal splitting and consensus can be broken down as temperature rises. We discuss the dependence of interaction strength Jc (with which the equal splitting occurs) on temperature T, the dependence of external field strength Bc (with which the consensus occurs) on interaction strength J at a certain temperature, as well as the scaling relations responsible for the probability of the full-negative configuration varying with temperature under different conditions. The findings provide us with a good description to understand opinion formation.
Energy is required for maximal adherence of Neisseria gonorrhoeae to phagocytic and nonphagocytic cells.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1989

description: Des inhibiteurs de la chaîne respiratoire comme le cyanure de potassium et l'amobacbitae réduisent la fixation des gonocoque sur des neutrophiles humains, des cellules Hela et des cellules HL-60. Le cyanure de potassium a peu d'effet sur l'association de Aphylicoccus avérés qui requiert des opsonines. L'énergie serait donc nécessaire pour une association maximale, indépendante de l'opsonine, avec des cellules mammaires.
A hierarchical cluster analysis of the psycological impact of the COVID-19 pandemic on Italian severe asthma patients
Creators: name: Guarnieri, G.
name: Chiurato, L.
name: Baiardini, I.
name: Caminati, M.
name: Senna, G
name: Scarpa, B.
name: Vianello, A.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Mental Health

description: In the context of COVID-19 pandemic a consistent medical concern raised among severe asthma patients though the studies excluded an increased risk of severe disease as well as an increased susceptibility. The aim of the study was to apply the Psychological General Well-Being Index (PGWBI) questionnaire to severe asthmatics during the COVID-19 pandemic and to evaluate data with a hierarchical cluster analysis. 114 severe asthmatics were asked to respond anonymously to the PGWBI questionnaire. The patients underwent lung functional test, fractional exhaled nitric oxide (FeNO) measurement, Asthma Control Test (ACT) and Asthma Control Questionnaire (ACQ6). A hierarchical cluster analysis was performed using an agglomerative approach and complete linkage to evaluate the results. The study population predominantly included female (60%), middle-aged patients, with normal lung function parameters, mild signs of airway and satisfactory asthma control. The PGWBI score (82.46 ± 16.53) of the study population showed a good state of psychological well-being and was similar to that of a representative sample of healthy adult Italian subjects. Thus Hierarchical cluster analysis identified 3 groups of patients: Cluster 1 (32%), Cluster 2 (64%), and Cluster 3 (4%). Whilst the Cluster 2 patients’ PGWBI score fell within the normal range, the Cluster 1 patients had a significantly lower total score (68.57 ± 7.2; p < 0.05), suggesting moderate distress. The Cluster 3 patients presented a total score markedly low. Conclusion Although the majority of the severe asthma patients studied demonstrated good mental well-being during the COVID-19 pandemic, some did indeed show moderate to severe psychological distress.
Non-reduction of relations in the Gromov space to Polish actions
Creators: name: López, Jesús A. Álvarez
name: Candel, Alberto
Publisher: name: arXiv
Year: 2015
Subjects: subject: Geometric Topology (math.GT)
subject: General Topology (math.GN)
subject: Metric Geometry (math.MG)
subject: FOS: Mathematics
subject: 3E15, 54H05, 54H20, 54E50

description: It is shown that, in the Gromov space of isometry classes of pointed proper metric spaces, the equivalence relations defined by existence of coarse quasi-isometries or being at finite Gromov-Hausdorff distance, cannot be reduced to the equivalence relation defined by any Polish action.
description: 9 pages. To appear in Notre Dame J. Form. Log. A small correction was made. arXiv admin note: text overlap with arXiv:1209.0307
Entry of genital Chlamydia trachomatis into polarized human epithelial cells.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1989

description: To study the initial invasion process(es) of genital chlamydiae, a model system consisting of hormonally maintained primary cultures of human endometrial gland epithelial cells (HEGEC), grown in a polarized orientation on collagen-coated filters, was utilized. After Chlamydia trachomatis inoculation of the apical surface of polarized HEGEC, chlamydiae were readily visualized, by transmission electron microscopy, in coated pits and coated vesicles. This was true for HEGEC maintained in physiologic concentrations of estrogen (proliferative phase) and of estrogen plus progesterone (secretory phase), despite the finding that association of chlamydiae with secretory-phase HEGEC is significantly reduced (P = 0.025; A.S. Maslow, C.H. Davis, J. Choong, and P.B. Wyrick, Am. J. Obstet. Gynecol. 159:1006-1014, 1988). In contrast, chlamydiae were rarely observed in the clathrin-associated structures if the HEGEC were cultured on plastic surfaces. The same pattern of coated pit versus noncoated pit entry was reproducible in HeLa cells. The quantity of coated pits associated with isolated membrane sheets derived from HeLa cells, grown on poly-L-lysine-coated cover slips in medium containing the female hormones, was not significantly different as monitored by radiolabeling studies and by laser scanning microscopy. These data suggest that culture conditions which mimic in vivo cellular organization may enhance entry into coated pits for some obligate intracellular pathogens.
MOIST Source code
Creators: name: Fu, Han
name: Si, Bingcheng
Publisher: name: Zenodo
Year: 2024
Subjects: MOIST
Fully coupled solution

description: This is a step-by-step illustration on how to run source code from version 1.0.

If you find codes cannot run on your end, you are welcome to share error details on https://github.com/HAN-2/MOIST_ERRORs/issues or send an email to haf033@usask.ca (Han).

I will help to debug and thank you for your interest!

Any new updates will be availble on this page.
Lower bound of multipartite concurrence based on sub-multipartite quantum systems
Creators: name: Chen, Wei
name: Zhu, Xue-Na
name: Fei, Shao-Min
name: Zheng, Zhu-Jun
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We study the concurrence of arbitrary dimensional multipartite quantum systems. An explicit analytical lower bound of concurrence for four-partite mixed states is obtained in terms of the concurrences of tripartite mixed states. Detailed examples are given to show that our lower bounds improve the existing lower bounds of concurrence. The approach is generalized to five-partite quantum systems.
description: 9 pages,2 figures, correct some errors
Femizid
Creators: name: Stauffer, Mina
name: Lörtscher, Clara
Publisher: name: Berner Fachhochschule - Soziale Arbeit
Year: 2022
Subjects: Femizid

description: In der Schweiz stellen Tötungsdelikte an Frauen keine Einzelfälle dar: Alle zwei Wochen wird eine Frau durch einen männlichen Täter getötet. Diese von Männern ausgehende tödliche Gewalt gegen Frauen aufgrund des Geschlechts wird Femizid genannt. Die vorliegende Bachelor-Thesis beschäftigt sich mit folgender Forschungsfrage: Was ist Femizid, worin liegt die Verbindung zu häuslicher Gewalt und welche Rolle kann die Soziale Arbeit bei Schutz- und Präventionsmassnahmen einnehmen? Der erste Teil widmet sich dem Phänomen «Femizid», den unterschiedlichen Definitionen und Erscheinungsformen sowie der Ursachenfindung. Femizide stellen ein globales und gesellschaftliches Problem dar, welches politischer Aufmerksamkeit bedarf und mit allen Mitteln bekämpft werden muss. Je nachdem, vor welchem politischen und kulturellen Kontext Femizide untersucht werden, ergeben sich Unterschiede in den Begrifflichkeiten, Definitionen, Ursachen und im Auftreten verschiedener Erscheinungsformen. Im Fokus des zweiten Kapitels steht die Situation in der Schweiz. Auf der Grundlage von vorhandenen Studien und Statistiken werden Femizide in der Schweiz analysiert. Besonderer Fokus liegt auf der Wahrnehmung und der Berichterstattung betreffend Femizid in den Medien und der Öffentlichkeit. Problematisch ist, dass die Schweiz Femizide in keiner offiziellen Statistik erfasst, oft «nur» von Tötungsdelikten an Frauen spricht, ohne dabei die Tatperson als männlich zu identifizieren, und dass Medien verharmlosend und täterfokussiert berichten. Daher werden Vorschläge formuliert, wie mediale Berichte achtsamer gestaltet werden können. Der Frage, inwiefern eine Verbindung zwischen häuslicher Gewalt und Femizid besteht, wird im dritten Teil nachgegangen. Häusliche Gewalt stellt ein erheblicher Risikofaktor für Femizide dar. Sie macht zudem einen grossen Anteil aller registrierten Straftaten in der Schweiz aus. In diesem Zusammenhang werden Modelle zur Beschreibung von Gewaltdynamiken sowie unterschiedliche Täterprofile untersucht, die Früherkennung ermöglichen und zur Interventionsplanung genutzt werden können. In einem nächsten Schritt werden häusliche Gewalt und Femizid als Handlungsfelder der Sozialen Arbeit ausgewiesen. In der Schweiz gibt es bereits eine grosse Auswahl an Präventions- und Schutzmassnahmen gegen Gewalt an Frauen und häusliche Gewalt. Gemäss Definition und dem Berufskodex kommt der Sozialen Arbeit eine aktive Rolle und Verantwortung bei der Bekämpfung häuslicher Gewalt (bzw. Femizid) zu. Es werden Empfehlungen für eine verstärkte Verhinderung von Femiziden durch die Soziale Arbeit abgegeben, die namentlich in den Bereichen Jugend-, Schul-, Opfer- sowie Täterarbeit angegliedert sind und die primäre, sekundäre sowie tertiäre Ebene der Gewaltprävention abdecken.
Additional file 1 of Cladribine treatment improves cortical network functionality in a mouse model of autoimmune encephalomyelitis
Creators: name: Schroeter, Christina B.
name: Rolfes, Leoni
name: Gothan, K. S. Sophie
name: Gruchot, Joel
name: Herrmann, Alexander M.
name: Bock, Stefanie
name: Fazio, Luca
name: Henes, Antonia
name: Narayanan, Venu
name: Pfeuffer, Steffen
name: Nelke, Christopher
name: Räuber, Saskia
name: Huntemann, Niklas
name: Duarte-Silva, Eduardo
name: Dobelmann, Vera
name: Hundehege, Petra
name: Wiendl, Heinz
name: Raba, Katharina
name: Küry, Patrick
name: Kremer, David
name: Ruck, Tobias
name: Müntefering, Thomas
name: Budde, Thomas
name: Cerina, Manuela
name: Meuth, Sven G.
Publisher: name: figshare
Year: 2022
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1: Figure S1. Experimental scheme. Active MOG EAE was induced as previously described by immunization (day 0) of C57BL/6J mice with MOG35–55 peptide, followed by pertussis toxin (PTX) injections (day 0 and day 2) (15). Mice were divided into two experimental groups: Group 1 received cladribine via oral gavage (10 mg/kg from day 5 to day 9), while group 2 received only the vehicle for the same period of time. On day 10 post-EAE induction, focal EAE lesions were generated by stereotactic injection of proinflammatory cytokines (interferon gamma (INF-γ) and tumor necrosis factor alpha (TNF-α) into the auditory cortex to induce cortical grey matter lesions. Experimental read-out (electrophysiological recordings, flow cytometric immunophenotyping, histology) was performed either on dmax (defining the day of maximal clinical deterioration) or on day 27 post-EAE induction (to assess the chronical EAE state).
Anti-IL-5/5Ra biologics improve work productivity and activity in severe asthma: a RAPSODI registry-based cohort study
Creators: name: van der Valk, J. P. M.
name: Hekking, P. P.
name: Rauh, S. P.
name: Patberg, K. W.
name: van Veen, I. A.
name: Van Huisstede, A.
name: Smeenk, F. W. J. M.
name: van de Ven, M. J. T.
name: Broeders, M. E. A. C.
name: Hilvering, B.
name: van Exsel, J.
name: Oud, K. T. M.
name: Langeveld, B.
name: Fieten, K. B.
name: van Veen, A.
name: Hashimoto, S.
name: Sont, J. K.
name: Brinke, A. ten
name: Braunstahl, G. J.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy

description: Severe asthma is associated with a serious disease burden, partially caused by limitations in activity and work impairment. This study aims to relate treatment with biologics targeting IL-5/5Ra to work productivity and activity in the long term in a real-world context. This is a registry-based multi-center cohort study evaluating data from adults with severe eosinophilic asthma included in the Dutch Register of Adult Patients with Severe Asthma for Optimal DIsease management (RAPSODI). Patients that started with anti-IL-5/5Ra biologics and completed the work productivity and activity improvement questionnaire, were included. Study and patient characteristics were compared between the employed and unemployed patients. Work productivity and activity impairment are related to accompanying improvements in clinical outcomes. At baseline, 91 of 137 patients (66%) were employed which remained stable throughout the follow-up period. Patients in the working age category were younger and had significantly better asthma control (p = 0.02). Mean overall work impairment due to health decreased significantly from 25.5% (SD2.6) to 17.6% (SD 2.8) during 12 months anti-IL-5/5Ra biologics treatment (P = 0.010). There was a significant association between ACQ6 and overall work improvement after targeted therapy (β = 8.7, CI 2.1–15.4, P = 0.01). The improvement of asthma control of 0.5 points on the asthma Control Questionnaire was associated with an overall work impairment of −9%. Work productivity and activity in severe eosinophilic asthma improved after starting anti-IL-5/5Ra biologics. Clinically relevant improvement in asthma control was associated with an overall work impairment score of −9% in this study.
Fusion of inclusions following superinfection of HeLa cells by two serovars of Chlamydia trachomatis.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1989

description: We employed serogroup-specific monoclonal antibodies with double-label immunofluorescence microscopy to study the intracellular development of superinfected HeLa 229 cells. We found that prior infection does not influence superinfection with another serovar of C. trachomatis during the first 24 h following the initial infection and that fusion of chlamydial phagosomes occurs throughout the intracellular developmental cycle.
Better together?
Creators: name: Bohren, Nora
name: Spahr, Vanessa Janine
Publisher: name: Berner Fachhochschule - Soziale Arbeit
Year: 2022
Subjects: Internationale Soziale Arbeit

description: Soziale Arbeit in Moshi, Tansania, ist durch die koloniale Vergangenheit und bis heute durch den Einfluss von fremden Menschen geprägt. «Fremd» bezeichnet hierbei den Gegenbegriff von «lokal». In allen Bereichen der Sozialen Arbeit ist die Frage der Legitimation bedeutsam. Im vorliegenden Papier wird eine kritische Auseinandersetzung bezüglich der Legitimation von fremden Sozialarbeiter*innen in Moshi vorgenommen. Diese wird unter anderem vor dem Hintergrund der daraus folgenden positiven sowie negativen Auswirkungen diskutiert. Die Thematik ist von Wichtigkeit, da in Moshi eine starke internationale Involvierung innerhalb des sozialen Sektors festzustellen ist. Daher erfordert es eine professionsrelevante Reflexion und Sensibilität seitens der fremden Sozialarbeiter*innen. Es stellt sich die Frage, inwiefern die Arbeit von fremden Sozialarbeitenden in Moshi legitimiert werden kann. Um diese Fragestellung anzugehen wird methodisch auf die Literatur wie auch auf den aktuellen Forschungsstand zurückgegriffen. Weiter wird eine qualitative Studie in Moshi durchgeführt, um die Sicht der Lokalen, mithilfe von semistrukturierten Interviews, zu ermitteln. Die Ergebnisse zeigen, dass die Frage der Legitimation komplex und nicht einfach zu beantworten ist. Allgemein gibt es erforschte Voraussetzungen für eine legitime Involvierung der fremden Sozialarbeitenden, welche eine Orientierung geben können. Die Landessprache Swahili zu sprechen, sowie über einen längeren Zeitraum in Moshi tätig zu sein, gilt gemäss den Interviewergebnissen als Voraussetzung. Über interkulturelle Kompetenzen zu verfügen, sowie eine Haltung des Interesses und der Neugierde einzunehmen, bilden die Grundlage der sozialarbeiterischen Tätigkeiten. Damit der Reproduktion von kolonialistischen Strukturen entgegengewirkt wird, ist ein selbstreflektierender Prozess unabdingbar. Den eigenen Normalitätsvorstellungen, wie auch den persönlichen Motivationen und Beweggründen bewusst zu sein, ist zentral für die internationale Tätigkeit. Diese werden durch individuelle Prägungen, sowie vorgängige Sozialisationsprozesse gebildet. Im Kontext Moshi sind die internationalen Sozialarbeitenden fremd und es ist zentral, sich dieser eigenen Fremdheit bewusst zu sein. Die Ergebnisse zeigen, dass die Interessen und Ideen der Lokalen priorisiert werden müssen und bei der Durchführung die Leitung bei ihnen liegen soll. Als Schlussfolgerung für die Soziale Arbeit zeigt sich, dass die Frage der Legitimation kontextabhängig ist. Es muss beachtet werden, wer sich in der Autoritätsposition befindet und bestimmt, wann etwas legitimiert werden kann. Der Kontext der Legitimationsfrage ist geprägt von Dilemmata. Diesen ausreichend Bedeutung zukommen zu lassen, ergibt sich nicht lediglich mit dem Abschluss des Studiums, sondern fordert von den Fachpersonen der Sozialen Arbeit eine ständige Wissenserweiterung und wiederholte Reflexionsprozesse.
Additional file 2 of Cladribine treatment improves cortical network functionality in a mouse model of autoimmune encephalomyelitis
Creators: name: Schroeter, Christina B.
name: Rolfes, Leoni
name: Gothan, K. S. Sophie
name: Gruchot, Joel
name: Herrmann, Alexander M.
name: Bock, Stefanie
name: Fazio, Luca
name: Henes, Antonia
name: Narayanan, Venu
name: Pfeuffer, Steffen
name: Nelke, Christopher
name: Räuber, Saskia
name: Huntemann, Niklas
name: Duarte-Silva, Eduardo
name: Dobelmann, Vera
name: Hundehege, Petra
name: Wiendl, Heinz
name: Raba, Katharina
name: Küry, Patrick
name: Kremer, David
name: Ruck, Tobias
name: Müntefering, Thomas
name: Budde, Thomas
name: Cerina, Manuela
name: Meuth, Sven G.
Publisher: name: figshare
Year: 2022
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 2: Figure S2. Titration curves of oral cladribine treatment in mice. In preliminary experiments, we analyzed the plasma [ng/ml] and brain concentrations [ng/g] of oral cladribine treatment with different doses (3.25, 5 and 10 mg/kg bodyweight) over a time period of 2.5 h. Every 30 min blood was drawn and a proportion of animals was killed to obtain brain tissue for titration analyses. Curves show the maximal concentration of cladribine in blood and brain tissue (Cmax [ng/ml or ng/g]), the time to maximal concentration (tmax [hours]) and the area under the curve (AUC [ng*h/ml or ng*h/g]).
Oxidant stress in Neisseria gonorrhoeae: adaptation and effects on L-(+)-lactate dehydrogenase activity.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1989

description: In this study, exposure of gonococci to sublethal concentrations of superoxide and hydrogen peroxide (and related O-centered radicals) resulted in phenotypic resistance to oxidant stress. Adaptation required new protein formation but was not related to increases in superoxide dismutase or catalase. Oxidant stress of greater magnitude than that required for adaptation led to a generalized increase in bacterial metabolism, particularly in L-(+)- and D-(―)-lactate utilization and lactate dehydrogenase activity.
Protracted anemia associated with chronic, relapsing systemic inflammation induced by arthropathic peptidoglycan-polysaccharide polymers in rats.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1989

description: Des déterminations d'hématocrite sont faites chez des rats auxquels des fragments de Streptocoques de groupe A du peptidoglycane-polysaccharide (PG-APS) sont injectés. Le PG-APS provoque une anémie récidivante chronique qui persiste pendant dix mois et qui se produit parallèlement à une arthrite périphérique. La survie des érythrocytes, qui sont microcytiques, est réduite. Le peptidoglycane purifié provoque une anémie aiguë alors que le polysaccharide n'affecte pas l'hématocrite. Les niveaux de Fer et de transferrine du sérum sont diminués dans des rats traités par la paroi cellulaire et sont corrélés aux valeurs d'hématocrite.
Optimierung Arbeitsintegration im Kanton Bern
Creators: name: Studer, Joel
name: Zeller, Kevin Jonas
Publisher: name: Berner Fachhochschule - Soziale Arbeit
Year: 2022
Subjects: Arbeitsintegration

description: Das Handlungsfeld der Arbeitsintegration im Kanton Bern soll ab 2025 mit dem Projekt «Optimierung Arbeitsintegration (AI-BE)» neu organisiert werden. Die vorliegende Arbeit untersucht mögliche Entwicklungen und Herausforderungen dieses Systemwechsels aus einer sozialarbeiterischen Perspektive. Daraus ergibt sich eine Diskussion um konkrete Handlungsoptionen für die Soziale Arbeit. Entlang von Spannungsfeldern gesellschaftlicher Verhältnisse und Entwicklungen werden die Begriffe Arbeit und Arbeitsintegration geklärt und diskutiert. Zudem wird die geplante Neuausrichtung der Arbeitsintegration im Kanton Bern beleuchtet. Diese theoretische Annäherung bildet den Ausgangspunkt für den Hauptteil der vorliegenden Arbeit. Dieser besteht aus einer inhaltlich strukturierenden qualitativen Inhaltsanalyse des Dokuments «Detailkonzept Projekt Optimierung Arbeitsintegration AI-BE», womit mögliche Entwicklungen, Herausforderungen und Handlungsoptionen aus sozialarbeitereischer Perspektive ausgearbeitet sowie beurteilt werden. Die Analyse hat gezeigt, dass der Kanton Bern mit der Optimierung der Arbeitsintegration den Weg in Richtung Sparmassnahmen, Deregulierung und Privatisierung einschlägt. Diese Entwicklungen haben für die Soziale Arbeit und ihre Klientel erhebliche Auswirkungen. Beispielsweise zeichnen sich im geplanten Systemwechsel normative Ausrichtungen hinsichtlich Eigenverantwortung und Aktivierung ab, während arbeitsmarktliche Realitäten und Chancen überwiegend unberücksichtigt bleiben. Weiter eröffnet die Neuausrichtung auf Ebene der Zielsetzung von Integrationsprozessen ein Spannungsfeld zwischen Effizienz und Nachhaltigkeit. Aus dieser Ausgangslage resultiert für Fachpersonen Sozialer Arbeit das zentrale Problem, die Qualität ihrer Unterstützungsleistungen weiterhin zu gewährleisten. Dies, weil Integrationsprozesse im Rahmen von AI-BE beispielsweise nicht auf die Herstellung von Kommunikation ausgerichtet sind und der Erfolg nicht entlang persönlicher Ermächtigung gemessen wird. Vielmehr richten sich diese an beschleunigten Vorgängen, die mitunter Vertrauensverhältnisse zwischen der Klientel und den Fachpersonen erschweren und dazu führen können, dass Unterstützungsleistungen zunehmend ins Leere laufen. Deshalb folgt als zentraler Handlungsbedarf, die berufsethischen Überzeugungen der Sozialen Arbeit in Erinnerung zu rufen. Darin führen Fachpersonen nicht nur aus, sondern sind gegenüber der eigenen Professionslogik Rechenschaft schuldig. Darüber hinaus zeigt sich die Wichtigkeit für die Soziale Arbeit, in diesem Rahmen danach bestrebt zu sein, über den Diskurs sowie über politische Prozesse ihre Verhältnisse zu verbessern und damit auch für die Anliegen der Klientel einzustehen.
Additional file 3 of Cladribine treatment improves cortical network functionality in a mouse model of autoimmune encephalomyelitis
Creators: name: Schroeter, Christina B.
name: Rolfes, Leoni
name: Gothan, K. S. Sophie
name: Gruchot, Joel
name: Herrmann, Alexander M.
name: Bock, Stefanie
name: Fazio, Luca
name: Henes, Antonia
name: Narayanan, Venu
name: Pfeuffer, Steffen
name: Nelke, Christopher
name: Räuber, Saskia
name: Huntemann, Niklas
name: Duarte-Silva, Eduardo
name: Dobelmann, Vera
name: Hundehege, Petra
name: Wiendl, Heinz
name: Raba, Katharina
name: Küry, Patrick
name: Kremer, David
name: Ruck, Tobias
name: Müntefering, Thomas
name: Budde, Thomas
name: Cerina, Manuela
name: Meuth, Sven G.
Publisher: name: figshare
Year: 2022
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 3: Figure S3. Gating strategy for flow cytometry. Single immune cells from the periphery (A, here exemplary shown with spleen tissue) and the central nervous system (CNS; B, here exemplary shown with spinal cord tissue) were simultaneously analyzed by flow cytometry. Total leukocytes were identified by forward scatter (FSC) and sideward scatter (SSC) and cell-doublets were removed by FSC width and FSC height gating. From these cells, we identified leukocytes subsets based on their surface marker expression: CD45R+ B cells; CD3+CD4+ T-helper cells, CD3+CD8+ cytotoxic T cells and CD4+CD8+ double positive T cells; CD3−NK1.1+ natural killer (NK) cells; CD11b+CD11c− monocytes and macrophages (M/M) and CD11b+CD11c+ dendritic cells. Regarding the CNS tissue, prior to discrimination of leukocyte subsets, we differentiated microglia cells (CD45med) from infiltrated leukocytes (CD45high).