cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Serotonergic antidepressant effects on aggressive, self-injurious and destructive/disruptive behaviours in intellectually disabled adults: a retrospective, open-label, naturalistic trial
Creators: name: Janowsky, David S.
name: Elamir, Belal
name: Davis, John M.
name: Barnhill, Jarrett
name: Shetty, Mahesh
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: There is a growing body of evidence that serotonergic antidepressants are useful in the treatment of maladaptive behaviours in the intellectually disabled. However, not all studies have shown positive results due to lack of efficacy, tolerance development, and troublesome side-effects. The current study consisted of a review of the treatment response to a variety of serotonergic antidepressants, consisting of selective serotonin reuptake inhibitors (SSRIs ) (
(2053) Michael Thomas Greenland
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 1 of The application of a surgical face mask over different oxygen delivery devices; a crossover study of measured end-tidal oxygen concentrations
Creators: name: Brown-Beresford, Kate
name: Currie, John
name: Thiruvenkatarajan, Venkatesan
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Figure 4. Demonstration of oxygen sampling tube attached below the subject’s nares, with either nasal cannula (4a) or Hudson Mask (4b) overlying. Figure 5. Demonstration of placement of overlying surgical mask, with either nasal cannula (5a) or Hudson Mask (5b) underneath.
Percolation in suspensions of hard nanoparticles: From spheres to needles
Creators: name: Schilling, Tanja
name: Miller, Mark
name: van der Schoot, Paul
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We investigate geometric percolation and scaling relations in suspensions of nanorods, covering the entire range of aspect ratios from spheres to extremely slender needles. A new version of connectedness percolation theory is introduced and tested against specialized Monte Carlo simulations. The theory accurately predicts percolation thresholds for aspect ratios as low as 10. The percolation threshold for rod-like particles of aspect ratios below 1000 deviates significantly from the inverse aspect ratio scaling prediction, thought to be valid in the limit of infinitely slender rods and often used as a rule of thumb for nano-fibers in composite materials. Hence, most fibers that are currently used as fillers in composite materials cannot be regarded as practically infinitely slender for the purposes of percolation theory. Comparing percolation thresholds of hard rods and new benchmark results for ideal rods, we find that (i) for large aspect ratios, they differ by a factor that is inversely proportional to the connectivity distance between the hard cores, and (ii) they approach the slender rod limit differently.
Low temperature equilibria in binary systems, including the solid phase
Creators: name: Moran, David William
Publisher: name: Imperial College London
Year: 2024

description: The vapour-liquid equilibrium behaviour of the three systems methane-cthane, methane-ethylene, and ethaneethylene has been investigated over a range of 0 to 2 atmospheres, using a dew-point, bubble-point type of apparatus. The data obtained for the ethane-cthylene system were tested for thermodynamic consistency. A limited amount of liquid phase density data was also obtained for the three systems. An apparatus was developed to investigate the solid-liquid phase diagrams for the systems methane-ethane, nethane-ethylene , ethane-ethylene , ethane-propane, nethane- propane, methane-nitrogen, and propylene-ethylene, using the method of thermal analysis. A review of the methods of correlating and predicting vapour-liquid equilibria was made and an equation was developed to cover the thermodynamic relationships in solid-liquid equilibria. All the systems investigated formed solid solutions and the deviation from ideal solid-solution behaviour was considerable.
Expert-Guided Symmetry Detection in Markov Decision Processes
Creators: name: Angelotti, Giorgio
name: Drougard, Nicolas
name: Chanel, Caroline P. C.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Learning a Markov Decision Process (MDP) from a fixed batch of trajectories is a non-trivial task whose outcome's quality depends on both the amount and the diversity of the sampled regions of the state-action space. Yet, many MDPs are endowed with invariant reward and transition functions with respect to some transformations of the current state and action. Being able to detect and exploit these structures could benefit not only the learning of the MDP but also the computation of its subsequent optimal control policy. In this work we propose a paradigm, based on Density Estimation methods, that aims to detect the presence of some already supposed transformations of the state-action space for which the MDP dynamics is invariant. We tested the proposed approach in a discrete toroidal grid environment and in two notorious environments of OpenAI's Gym Learning Suite. The results demonstrate that the model distributional shift is reduced when the dataset is augmented with the data obtained by using the detected symmetries, allowing for a more thorough and data-efficient learning of the transition functions.
description: Accepted to the 14th International Conference on Agents and Artificial Intelligence - ICAART 2022
Carbonatation accélérée de granulats de béton recyclé – Évolution des propriétés selon leur classe granulaire
Creators: name: Braymand, Sandrine
name: Roux, Sébastien
name: Schlupp, Florian
name: Mercado Mendoza, Hugo
Publisher: name: Academic Journal of Civil Engineering
Year: 2022

description: Les granulats de béton recyclé (GBR) sont aujourd’hui couramment utilisés dans les bétons. Cependant, certaines de leurs propriétés amoindries et leur variabilité sont un facteur limitant pour une large mise en œuvre. En obstruant les accès au réseau poreux, le traitement des GBR par carbonatation accélérée, réduit la porosité accessible qui affecte l'absorption d'eau. Cette problématique est étudiée dans le cadre du projet national FastCarb. Ce travail analyse l'influence de la carbonatation accélérée sur l'évolution des propriétés des GBR et leur variabilité en fonction des classes granulaires. Il est montré que, pour les petites classes granulaires, l’absorption et la teneur en CaCO3 évoluent de façon plus marquée et la variabilité sur l’essai d’absorption est plus nettement réduite à l’issue du traitement.
description: Academic Journal of Civil Engineering, Vol 40 No 1 (2022): Special Issue - RUGC 2022
Chameleon JupyterHub Appliance
Creators: name: Anderson, Jason
Publisher: name: Zenodo
Year: 2019
Subjects: chameleon
jupyter
jupyterhub

description: [JupyterHub](https://jupyter.org/hub) is a multi-user Jupyter Notebook environment that allows easy management of multiple Notebook servers. You can install this application on a node reserved by Chameleon to allow you to take advantage of additional resources, e.g. a private experiment network you provide or accelerator devices such as GPUs. This appliance is exposed over the public internet via a TLS-secured endpoint and supports other users logging in with their Chameleon credentials, so you can choose to share the server with other collaborators if you wish.
(2055) Eliza Greenland
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The big bang of halide perovskites: The starting point of crystallization
Creators: name: Saura, Ana Palacios
name: Breternitz, Joachim
name: Hoell, Armin
name: Schorr, Susan
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Colloid
subject: Core/shell
subject: Crystal growth
subject: Liquid
subject: Organometallic
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::550 Geowissenschaften

description: Hybrid halide perovskites (HHPs) are very promising absorber materials for solar cells due to their high power conversion efficiency and the low-cost solution-based processing methods. We applied small angle X-ray scattering to MAPbI3, FAPbI3 and MAPbBr3 precursor solutions in different solvents (GBL, DMF, and mixtures) to gain a deeper understanding of the building blocks during the early stage of HHP formation. We present a core–shell model where the core is formed by [PbX6] octahedra surrounded by a shell of solvent molecules, which explains the arrangement of the precursors in solution and how the solvent and the halide influence such arrangement.
Record breaking bursts in a fiber bundle model of creep rupture
Creators: name: Danku, Zsuzsa
name: Kun, Ferenc
Publisher: name: arXiv
Year: 2015
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: We investigate the statistics of record breaking events in the time series of crackling bursts in a fiber bundle model of the creep rupture of heterogeneous materials. In the model fibers break due to two mechanisms: slowly accumulating damage triggers bursts of immediate breakings analogous to acoustic emissions in experiments. The rupture process accelerates such that the size of breaking avalanches increases while the waiting time between consecutive events decreases towards failure. Record events are defined as bursts which have a larger size than all previous events in the time series. We analyze the statistics of records focusing on the limit of equal load sharing (ELS) of the model and compare the results to the record statistics of sequences of independent identically distributed random variables. Computer simulations revealed that the number of records grows with the logarithm of the event number except for the close vicinity of macroscopic failure where an exponential dependence is evidenced. The two regimes can be attributed to the dominance of disorder with small burst sizes and to stress enhancements giving rise efficient triggering of extended bursts, respectively. Both the size of records and the increments between consecutive record events are characterized by power law distributions with a common exponent 1.33 significantly different from the usual ELS burst size exponents of fiber bundles. The distribution of waiting times follows the same behavior, however, with two distinct exponents for low and high loads. Studying the evolution of records we identify a load dependent characteristic scale of the system which separates slow down and acceleration of record breaking as failure is approached.
description: 12 pages, 6 figures
(2056) Lucy Greenland
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Machine learning methods for compound annotation in non-targeted mass spectrometry—A brief overview of fingerprinting, in silico fragmentation and de novo methods
Creators: name: Russo, Francesco F.
name: Nowatzky, Yannek
name: Jaeger, Carsten
name: Parr, Maria K.
name: Benner, Phillipp
name: Muth, Thilo
name: Lisec, Jan
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: non-targeted screenings
subject: non-targeted mass spectrometry
subject: machine learning
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Non-targeted screenings (NTS) are essential tools in different fields, such as forensics, health and environmental sciences. NTSs often employ mass spectrometry (MS) methods due to their high throughput and sensitivity in comparison to, for example, nuclear magnetic resonance–based methods. As the identification of mass spectral signals, called annotation, is labour intensive, it has been used for developing supporting tools based on machine learning (ML). However, both the diversity of mass spectral signals and the sheer quantity of different ML tools developed for compound annotation present a challenge for researchers in maintaining a comprehensive overview of the field. In this work, we illustrate which ML-based methods are available for compound annotation in non-targeted MS experiments and provide a nuanced comparison of the ML models used in MS data analysis, unravelling their unique features and performance metrics. Through this overview we support researchers to judiciously apply these tools in their daily research. This review also offers a detailed exploration of methods and datasets to show gaps in current methods, and promising target areas, offering a starting point for developers intending to improve existing methodologies.
humm3: a flexible, precise heat solution for rapid, controllable and safe layup of thermoplastics
Creators: name: Kolbe, Andreas
Publisher: name: Zenodo
Year: 2019
Subjects: Xenon heating, thermoplastics manufacturing, automated fibre lay-upd

description: Flyer presented at the JEC 2019. It describes the developments of a Xenon flash lamp for manufacturing of thermoplastic carbon fibre reinforced plastics.
description: Acknowledgement: This project has received funding from the Clean Sky 2 Joint Undertaking (JU) under grant agreement No 807097. The JU receives support from the European Union's Horizon 2020 research and innovation programme and the Clean Sky 2 JU members other than the Union. Disclaimer: The results, opinions, conclusions, etc. presented in this work are those of the author(s) only and do not necessarily represent the position of the JU; the JU is not responsible for any use made of the information contained herein.
Effect of saturation degree on the behaviour of clear sand in very dense state
Creators: name: TRAN, Khai Hoan
name: Imanzadeh, Saber
name: Taibi, Said
name: Souli, Hanène
name: Fleureau, Jean-Marie
name: Hattab, Mahdia
Publisher: name: Academic Journal of Civil Engineering
Year: 2022

description: In this paper, a series of tests were carried out to investigate the effect of saturation degree on the liquefaction behaviour of Hostun sand in a very dense state. All the samples were reconstituted by the wet tamping method at a high relative density of 83%. After sample wetting and sample consolidation, the samples having different saturation degrees have been subjected to cyclic loading to study the liquefaction behaviour. The Cyclic Stress Ratio (CSR) of the cyclic loading increased after a given number of cycles until the liquefaction of material. The results show that even though the samples were in a very dense state and not fully saturated, they were liquefied under cyclic loading with increasing CSR. The saturation degree or Skempton's coefficient B affects significantly the liquefaction potential of samples. A decrease of B value from 0.97 to 0.7 results in the increase of CSR needed to liquefy the samples from 0.25 to 0.35. However, the effect of this parameter on the friction angle seems not to be clear.
description: Academic Journal of Civil Engineering, Vol 40 No 1 (2022): Special Issue - RUGC 2022
A pilot effectiveness study: placebo-controlled trial of adjunctive L-triiodothyronine (T3) used to accelerate and potentiate the antidepressant response
Creators: name: Hennessey, James
name: Joffe, Russell
name: Posternak, Michael
name: Stern, Robert
name: Prange Jr., Arthur
name: Zimmerman, Mark
name: Novak, Scott
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The aim was to evaluate whether adjunctive T3 can help accelerate the antidepressant response and improve overall outcomes when used under naturalistic conditions. Fifty consecutive psychiatric outpatients diagnosed with major depressive disorder who were initiated on antidepressant therapy were randomized to receive adjunctive T3 or placebo in a double-blind manner over the course of 6 wk. There were no restrictions placed on the selection of antidepressant agent, dosing, ancillary medications, or psychotherapy, and there were few exclusion criteria. A positive response was defined as a > or = 50% reduction in Montgomery-Asberg Depression Rating Scale scores. Response rates were higher for the adjunctive T3 cohort compared to the adjunctive placebo cohort after 1 wk (45% vs. 24%) and 2 wk (57% vs. 33%) of treatment. The likelihood of experiencing a positive response at any point over the 6-wk trial was 4.5 times greater in the adjunctive T3 cohort (95% CI 1.3-15.7). The study provides preliminary evidence that T3 can successfully be used in clinical practice to accelerate the antidepressant response and improve overall outcomes. The effectiveness model may be an untapped mechanism for evaluating the value of psychopharmacological agents.
(2052) Eliza [Greenland]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Planar Hall effect induced spin rectification effect and its strong impact on spin pumping measurements
Creators: name: He, Kang
name: Cheng, Jun
name: Yang, Man
name: Zhang, Yihui
name: Yu, Longqian
name: Liu, Qi
name: Sun, Liang
name: Miao, Bingfeng
name: Hu, Canming
name: Ding, Haifeng
Publisher: name: arXiv
Year: 2021
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: Spin pumping is a technique widely used to generate the pure spin current and characterize the spin-charge conversion in various systems. The reversing sign of the symmetric Lorentzian charge current with respect to opposite magnetic field is generally accepted as the key criterion to identify its pure spin current origin. However, we herein find that the rectified voltage due to the planar Hall effect can exhibit similar spurious signal, complicating and even misleading the analysis. The distribution of microwave magnetic field and induction current has strong influence on the magnetic field symmetry and lineshape of the obtained signal. We further demonstrate a geometry where the spin-charge conversion and the rectified voltage can be readily distinguished with a straightforward symmetry analysis.
Rotating spintronic terahertz emitter optimized for microjoule pump-pulse energies and megahertz repetition rates
Creators: name: Vaitsi, Alkisti
name: Sleziona, Vivien
name: Parra López, Luis E.
name: Behovits, Yannic
name: Schulz, Fabian
name: Martín Sabanés, Natalia
name: Kampfrath, Tobias
name: Wolf, Martin
name: Seifert, Tom S.
name: Müller, Melanie
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: spintronic terahertz emitters
subject: microjoule pump-pulse energies
subject: megahertz repetition rates
subject: 500 Naturwissenschaften und Mathematik::530 Physik::530 Physik

description: Spintronic terahertz emitters (STEs) are powerful sources of ultra-broadband single-cycle terahertz (THz) field transients. They work with any pump wavelength, and their polarity and polarization direction are easily adjustable. However, at high pump powers and high repetition rates, STE operation is hampered by a significant increase in the local temperature. Here, we resolve this issue by rotating the STE at a few 100 Hz, thereby distributing the absorbed pump power over a larger area. Our approach permits stable STE operation at a fluence of ∼1 mJ/cm2 with up to 18 W pump power at megahertz repetition rates, corresponding to pump-pulse energies of a few 10 μJ and pump power densities approaching 1 kW/cm2. The rotating STE is of interest for all ultra-broadband high-power terahertz applications requiring high repetition rates. As an example, we show that terahertz pulses with peak fields of 10 kV/cm can be coupled to a terahertz-light wave-driven scanning tunneling microscope at 1 MHz repetition rate, demonstrating that the rotating STE can compete with standard terahertz sources such as LiNbO3.
(2054) Sydney Greenland
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Increased stress-evoked nitric oxide signalling in the Flinders sensitive line (FSL) rat: a genetic animal model of depression
Creators: name: Harvey, Brian H.
name: Müller, Heidi K.
name: Bonefeld, Birgit
name: Volke, Vallo
name: Elfving, Betina
name: Overstreet, David H.
name: Wegener, Gregers
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Stress engenders the precipitation and progression of affective disorders, while stress-related release of excitatory mediators is implicated in the degenerative pathology observed especially in the hippocampus of patients with severe depression. Nitric oxide (NO) release following stress-evoked
Dataset 3 key from Phylogenetic and functional evidence suggests that deep-ocean ecosystems are highly sensitive to environmental change and direct human disturbance.
Creators: name: Ashford, Oliver S.
name: Kenny, Andrew J.
name: Froján, Christopher R. S. Barrio
name: Bonsall, Michael B.
name: Horton, Tammy
name: Brandt, Angelika
name: Bird, Graham J.
name: Gerken, Sarah
name: Rogers, Alex D.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Environmental Science
subject: Ecology
subject: FOS: Biological sciences

description: Key to references cited in Dataset 3.
Path release among practices in the process of path constitution: How the MP3-path appeared in the field of recorded music
Creators: name: Sminia, Harry
name: Bohn, Stephan
name: Sydow, Jörg
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: path constitution
subject: path release
subject: MP3-path
subject: 300 Sozialwissenschaften::330 Wirtschaft::330 Wirtschaft

description: Adopting a practice-based approach informed by structuration theory, we report on the establishment of the MP3-path from 1997 to 2004 as a process of path constitution that introduced a new path-dependent patterning among the practices in the field of recorded music. This case helps us elaborate a practice-based and more integrated theory of path constitution that incorporates both the production of path dependence and the release from the limitations that path dependence imposes on choice. The empirical investigation rests on a mixed-methods approach combining topic modeling with longitudinal historical research. By distinguishing between practices and entrepreneurial initiatives, we explain how a critical path-release juncture emancipated practices from existing path dependence (the CD-path), which was followed by a path-creation juncture that triggered the production of a new MP3-path. We synthesize the concepts and findings to develop an integrated model of path constitution and thereby contribute to the literature on path dependence.
(2050) Adeline Bates
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Evaluation of sensor-based health monitoring in dairy cows: Exploiting rumination times for health alerts around parturition
Creators: name: Simoni, A.
name: König, F.
name: Weimar, K.
name: Hancock, A.
name: Wunderlich, C.
name: Klawitter, M.
name: Breuer, T.
name: Drillich, Marc
name: Iwersen, M.
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: health alert
subject: accelerometer
subject: herd health management
subject: rumination time
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

description: The use of sensor-based measures of rumination time as a parameter for early disease detection has received a lot of attention in scientific research. This study aimed to assess the accuracy of health alerts triggered by a sensor-based accelerometer system within 2 different management strategies on a commercial dairy farm. Multiparous Holstein cows were enrolled during the dry-off period and randomly allocated to conventional (CON) or sensor-based (SEN) management groups at calving. All cows were monitored for disorders for a minimum of 10 DIM following standardized operating procedures (SOP). The CON group (n = 199) followed an established monitoring protocol on the farm. The health alerts of this group were not available during the study but were later included in the analysis. The SEN group (n = 197) was only investigated when the sensor system triggered a health alert, and a more intensive monitoring approach was implemented according to the SOP. To analyze the efficiency of the health alerts in detecting disorders, the sensitivity (SE) and specificity (SP) of health alerts were determined for the CON group. In addition, all cows were divided into 3 subgroups based on their health status and the status of the health alerts in order to retrospectively compare the course of rumination time. Most health alerts (87%, n = 217) occurred on DIM 1. For the confirmation of diagnoses, health alerts showed SE and SP levels of 71% and 47% for CON cows. In SEN cows, SE of 71% and 75% and SP of 48% and 43% were found for the detection of ketosis and hypocalcemia, respectively. The rumination time of the subgroups was affected by DIM and the interaction between DIM and the status of health alert and health condition.
Correlates and outcomes of depressed out-patients with greater and fewer anxious symptoms: a CO-MED report
Creators: name: Morris, David
name: Balasubramani, G. K.
name: John Rush, A.
name: Wisniewski, Stephen R.
name: Trivedi, Madhukar
name: Nierenberg, Andrew A.
name: Davis, Lori
name: Friedman, Edward S.
name: Chan, Herng Nieng
name: Fava, Maurizio
name: Gaynes, Bradley N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The objective of this paper was to determine whether the presence of more
Phonon-thermoelectric transistors and rectifiers
Creators: name: Jiang, Jian-Hua
name: Kulkarni, Manas
name: Segal, Dvira
name: Imry, Yoseph
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We describe nonlinear phonon-thermoelectric devices where charge current and electronic and phononic heat currents are coupled, driven by voltage and temperature biases, when phonon-assisted inelastic processes dominate the transport. Our thermoelectric transistors and rectifiers can be realized in a gate-tunable double quantum-dot system embedded in a nanowire which is realizable within current technology. The inelastic electron-phonon scattering processes are found to induce pronounced charge, heat, and cross rectification effects, as well as a thermal transistor effect that, remarkably, can appear in the present model even in the linear-response regime without relying on negative differential thermal conductance.
(2051) Alfred Greenland
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Auf der Suche nach einem Platz an der Sonne
title: Politische Strategien deutscher Einwanderer in Rio Grande do Sul, Brasilien, im 19. Jahrhundert
titleType: Subtitle
Creators: name: Witt, Marcos Antônio
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Deutsche Auswanderung
subject: Politische Beiteiligung
subject: Rio Grande do Sul
subject: 19. Jahrhundert
subject: Einwandererliteratur
subject: Wahlen
subject: Öffentliche Ämter
subject: Brasilien
subject: Mikrogeschichte
subject: Konflikte
subject: 900 Geschichte und Geografie::980 Geschichte Südamerikas::980 Geschichte Südamerikas

description: Die Studie zum 19. Jahrhundert untersucht, wie sich deutsche Einwanderer und ihre Nachkommen in der brasilianischen Provinz Rio Grande do Sul politisch organisierten und einbrachten. Im Mittelpunkt stehen die sogenannten „exponentiellen“ deutschen Siedler und ihre Strategien, um in die Politik zu gelangen und politische Räume wie öffentliche Ämter zu besetzen, die Ausländern eigentlich nicht offenstanden.
Koala retrovirus and neoplasia: correlation and underlying mechanisms
Creators: name: Tarlinton, Rachael
name: Greenwood, Alex D.
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Koala retrovirus
subject: neoplasia
subject: correlation
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

description: The koala retrovirus, KoRV, is one of the few models for understanding the health consequences of retroviral colonization of the germline. Such colonization events transition exogenous infectious retroviruses to Mendelian traits or endogenous retroviruses (ERVs). KoRV is currently in a transitional state from exogenous retrovirus to ERV, which in koalas (Phascolarctos cinereus) has been associated with strongly elevated levels of neoplasia. In this review, we describe what is currently known about the associations and underlying mechanisms of KoRV-induced neoplasia.
Digital topographic analysis and lineament interpretation south of the Lena Delta, North Siberia: Landscape expression of its tectonic activity
Creators: name: Hamann, Jakob S.
name: Baranskaya, Alisa V.
name: Geissler, Wolfram H.
name: Baranov, Boris V.
name: Tsukanov, Nikolay V.
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Tectonic Geomorphology
subject: Lineament Identification
subject: Topographic Analysis
subject: Hypsometry
subject: Arctic Landscapes
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::550 Geowissenschaften

description: This study applies semi-automated techniques to analyze the landforms, morphostructure, and geology of the Kharaulakh and Chekanovsky sectors, south of the Lena Delta, northern Siberia. High-resolution data, including TanDEM-X 30 m spatial resolution Digital Elevation Models (DEM), 2 m spatial resolution ArcticDEM Digital Surface Models (DSM), and Sentinel-2 satellite imagery, serve as the basis for the analysis. Digital terrain classification and identification of tectonic lineaments are performed using the Benthic Terrain Modeler (BTM) and Linear Extraction (LINE) algorithm, respectively. Additionally, a hypsometric analysis is conducted to assess areas of potential neotectonic activity. 873 lineaments are identified, primarily in NE-SW and E-W orientations. NW-SE lineaments perpendicular to the lithological and fold belt strikes in the Kharaulakh Ridge suggest inheritance from original depositional settings or later compressional tectonics, now appearing as valleys and weak zones facilitating erosion and river incision. Longer N-S or NNW-SSE lineaments in the Kharaulakh Sector are associated with thrust sheets of the Verkhoyansk fold-and-thrust belt and Cenozoic graben structures linked to the formation of the Laptev Sea Rift System and ongoing regional deformation. The Chekanovsky Sector, marked by epiplatform blocks and hills, presents a dissected plateau with steep valleys. Here, high hypsometric integral values are attributed to compression and uplift near the southwestern boundary of the Laptev Sea Microplate.
title: The impact which social networks have upon the development of small professional business service firms
Creators: name: Shaw, Eleanor
Publisher: name: University of Glasgow
Year: 1997
Subjects: subject: Business administration.

description: The purpose of this thesis is to acquire an understanding of the impact which the micro environment in which a purposive sample of small graphic design agencies are embedded has upon their development which will offer practical recommendations to the owner-managers of small professional business service firms as well as make suggestions for policy and future research. For the purposes of acquiring such an understanding the concept of a social network (Mitchell 1969) is used to guide the collection of data about participants' perceptions of the impact which the relationships in which small graphic design agencies are embedded has had upon their development. The findings to emerge from inductive analysis of this data suggest that one factor contributing to the development of a purposive sample of small graphic design agencies were the social networks in which they were embedded. Particularly this analysis identifies the multiplex relationships which case-firms shared within individuals holding 'broker' positions within these networks as having had an important impact on their development. Further, this analysis suggests that participants involvement in 'networking' activities and owner- managers' control of these were also important in the development of case-firms, This analysis also identifies a number of influencing factors which suggest that certain findings may be specific to small graphic design agencies. The thesis concludes that the social network concept was a useful construct for conceiving of the relationships in which case-firms were embedded and identifies a number of recommendations for the owner-managers of small professional business service firms as well as for research and policy.
Additional file 1 of Alternative medicine: therapeutic effects on gastric original signet ring carcinoma via ascorbate and combination with sodium alpha lipoate
Creators: name: Chen, Weiyu
name: Xu, Lingyun
name: Chang, Edwin
name: Gowrishankar, Gayatri
name: Ferrara, Katherine W.
name: Gambhir, Sanjiv Sam
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Additional file 1.
A Kinase-deficient Splice Variant of the Human JAK3 Is Expressed in Hematopoietic and Epithelial Cancer Cells
Creators: name: Jin, Y.
name: Graham, D. K.
name: Koon Siew Lai,
name: Witthuhn, B. A.
name: Ihle, J. N.
name: Liu, E. T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: Signal transduction of cytokine receptors is mediated by the JAK family of tyrosine kinases. Recently, the kinase partners for the interleukin (IL)-2 receptor have been identified as JAK1 and JAK3. In this study, we report the identification of splice variants that may modulate JAK3 signaling. Three splice variants were isolated from different mRNA sources: breast (B), spleen (S), and activated monocytes (M). Sequence analysis revealed that the splice variants contain identical NH2-terminal regions but diverge at the COOH termini. Analyses of expression of the JAK3 splice isoforms by reverse transcriptase-polymerase chain reaction on a panel of cell lines show splice preferences in different cell lines: the S-form is more commonly seen in hematopoietic lines, whereas the B- and M-forms are detected in cells both of hematopoietic and epithelial origins. Antibodies raised against peptides to the B-form splice variant confirmed that the 125-kDa JAK3B protein product is found abundantly in hematopoietic as well as epithelial cells, including primary breast cancers. The lack of subdomain XI in the tyrosine kinase core of the B-form JAK3 protein suggests that it is a defective kinase. This is supported by the lack of detected autokinase activity of the B-form JAK3. Intriguingly, both the S and B splice isoforms of JAK3 appear to co-immunoprecipitate with the IL-2 receptor from HUT-78 cell lysates. This and the presence of multiple COOH-terminal splice variants coexpressed in the same cells suggest that the JAK3 splice isoforms are functional in JAK3 signaling and may enrich the complexity of the intracellular responses functional in IL-2 or cytokine signaling.
Angiotensin II activates at least two tyrosine kinases in rat liver epithelial cells. Separation of the major calcium-regulated tyrosine kinase from p125(FAK)
Creators: name: Graves, L. M.
name: Earp, H. S.
name: Dy, R.
name: Li, X.
name: Huckle, W. R.
name: Dawson, T. L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: In rat liver epithelial cell lines (WB or GN4), angiotensin II (Ang II) stimulates cytosolic tyrosine kinase activity, in part, through a calcium-dependent mechanism. In other cell types, selected hormones that activate Gi- or Gq-coupled receptors stimulate the soluble tyrosine kinase, p125FAK. Immunoprecipitation of p125FAK from Ang II-activated GN4 cells demonstrated a doubling of p125FAK kinase activity. However, an additional Ang II-activated tyrosine kinase (or kinases) representing the majority of the total activity was detected when the remaining cell lysate, immunodepleted of p125FAK, was reimmunoprecipitated with an anti-phosphotyrosine antibody. Cytochalasin D pretreatment blocks G-protein receptor-dependent tyrosine phosphorylation in Swiss 3T3 cells. While cytochalasin D decreased the Tyr(P) content of 65-75-kDa substrates in Ang II-treated GN4 cells, it did not diminish tyrosine phosphorylation of 115-130-kDa substrates, again suggesting activation of at least two tyrosine kinase pathways in GN4 cells. To search for additional Ang II-activated enzymes, we used molecular techniques to identify 20 tyrosine kinase sequences in these cell lines. None was the major cytosolic enzyme activated by Ang II. Specifically, JAK2, which had been shown by others to be stimulated by Ang II in smooth muscle cells, was not activated by Ang II in GN4 cells. Finally, we purified Tyr(P)-containing tyrosine kinases from Ang II-treated cells, using anti-Tyr(P) and ATP affinity resins; 80% of the tyrosine kinase activity migrated as a single 115-120-kDa tyrosine-phosphorylated protein immunologically distinct from p125FAK. In summary, Ang II activates at least two separate tyrosine kinases in rat liver epithelial cells; p125FAK and a presumably novel, cytosolic 115-120-kDa protein referred to as the calcium-dependent tyrosine kinase.
Association of Aciculin with Dystrophin and Utrophin
Creators: name: Belkin, A. M.
name: Burridge, K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: Aciculin is a recently identified 60-kDa cytoskeletal protein, highly homologous to the glycolytic enzyme phosphoglucomutase type 1, (Belkin, A. M., Klimanskaya, I. V., Lukashev, M. E., Lilley, K., Critchley, D., and Koteliansky, V. E. (1994) J. Cell Sci. 107, 159-173). Aciculin expression in skeletal muscle is developmentally regulated, and this protein is particularly enriched at cell-matrix adherens junctions of muscle cells (Belkin, A. M., and Burridge, K. (1994) J. Cell Sci. 107, 1993-2003). The purpose of our study was to identify cytoskeletal protein(s) interacting with aciculin in various cell types. Using immunoprecipitation from cell lysates of metabolically labeled differentiating C2C12 muscle cells with anti-aciculin-specific antibodies, we detected a high molecular weight band (M(r) approximately 400,000), consistently coprecipitating with aciculin. We showed that this 400 kDa band comigrated with dystrophin and immunoblotted with anti-dystrophin antibodies. The association between aciculin and dystrophin in C2C12 cells was shown to resist Triton X-100 extraction and the majority of the complex could be extracted only in the presence of ionic detergents. In the reverse immunoprecipitation experiments, aciculin was detected in the precipitates with different anti-dystrophin antibodies. Immunodepletion experiments with lysates of metabolically labeled C2C12 myotubes showed that aciculin is a major dystrophin-associated protein in cultured skeletal muscle cells. Double immunostaining of differentiating and mature C2C12 myotubes with antibodies against aciculin and dystrophin revealed precise colocalization of these two cytoskeletal proteins throughout the process of myodifferentiation in culture. In skeletal muscle tissue, both proteins are concentrated at the sarcolemma and at myotendinous junctions. In contrast, utrophin, an autosomal homologue of dystrophin, was not codistributed with aciculin in muscle cell cultures and in skeletal muscle tissues. Analytical gel filtration experiments with purified aciculin and dystrophin showed interaction of these proteins in vitro, indicating that their association in skeletal muscle is due to direct binding. Whereas dystrophin was shown to be a major aciculin-associated protein in skeletal muscle, immunoblotting of anti-aciculin immunoprecipitates with antibodies against utrophin showed that aciculin is associated with utrophin in cultured A7r5 smooth muscle cells and REF52 fibroblasts. Immunodepletion experiments performed with lysates of metabolically labeled A7r5 cells demonstrated that aciculin is a major utrophin-binding protein in this cell type. Taken together, our data show that aciculin is a novel dystrophin- and utrophin-binding protein. Association of aciculin with dystrophin (utrophin) in various cell types might provide an additional cytoskeletal-matrix transmembrane link at sites where actin filaments terminate at the plasma membrane.
(2046) Elizabeth Clark Bates
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.