cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Dissemination of Evidence-based Atypical Antipsychotic Information to Nursing Homes
Creators: name: Lemay, Celeste A.
name: Tjia, Jennifer
name: Mazor, Kathleen M.
name: Field, Terry S.
name: Kanaan, Abir O.
name: Donovan, Jennifer L.
name: Gurwitz, Jerry H.
Publisher: name: eScholarship@UMMS
Year: 2013

description: Background: Accumulating evidence demonstrates minimal benefit and increased risk of off-label use of atypical antipsychotic medications for dementia-related behaviors. Optimal strategy for disseminating evidence-based guides to nursing home (NH) stakeholders is unclear. Our objective is to describe the impact of differing dissemination efforts in Connecticut NHs.

Methods: Forty-three Connecticut NHs were randomized to one of 3 arms receiving incrementally intensive dissemination strategies of the Agency for Healthcare Research and Quality Comparative Effectiveness Review Summary Guide on the off-label use of atypical antipsychotic drugs, which was included in a toolkit informed by a needs assessment of NHs. All NHs received the paper-based toolkit and notifications regarding the online toolkit. Additionally, Arm 2 received individualized quarterly audit and feedback reports with atypical antipsychotic prescribing rates; Arm 3 received in-person educational visits and audit and feedback reports. Toolkit reach was assessed using interviews with NH leadership and staff. Online toolkit use was assessed using Google analytics.

Results: Eighty leaders and 222 direct care staff were interviewed. Leadership and direct care staff in Arm 3 NHs were more likely to be familiar with the toolkit that those in Arm 1 (p=0.008) and Arm 2 (p

Conclusions: Intensive dissemination, using multi-pronged approach including academic detailing and direct care staff trainings, appeared to be associated with higher familiarity with paper-based toolkit, but not Internet-based use of the toolkit in the NH setting.
Boosting the 3D thermal-aware floorplanning problem through a master-worker parallel MOEA
Creators: name: Arnaldo, Ignacio
name: Cuesta-Infante, Alfredo
name: Colmenar, J. Manuel
name: Risco-Martín, José L.
name: Ayala, José L.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Hardware Architecture (cs.AR)
subject: FOS: Computer and information sciences

description: The increasing transistor scale integration poses, among others, the thermal-aware floorplanning problem; consisting of how to place the hardware components in order to reduce overheating by dissipation. Due to the huge amount of feasible floorplans, most of the solutions found in the literature include an evolutionary algorithm for, either partially or completely, carrying out the task of floorplanning. Evolutionary algorithms usually have a bottleneck in the fitness evaluation. In the problem of thermal-aware floorplanning, the layout evaluation by the thermal model takes 99.5\% of the computational time for the best floorplanning algorithm proposed so far.The contribution of this paper is to present a parallelization of this evaluation phase in a master$-$worker model to achieve a dramatic speed-up of the thermal-aware floorplanning process. Exhaustive experimentation was done over three dimensional integrated circuits, with 48 and 128 cores, outperforming previous published works.
On the contribution of plasminos to the shear viscosity of a hot and dense Yukawa-Fermi gas
Creators: name: Sadooghi, N.
name: Taghinavaz, F.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We determine the shear viscosity of a hot and dense Yukawa-Fermi gas, using the standard Green-Kubo relation, according to which the shear viscosity is given by the retarded correlator of the traceless part of viscous energy-momentum tensor. We approximate this retarded correlator using a one-loop skeleton expansion, and express the bosonic and fermionic shear viscosities, $η_{b}$ and $η_{f}$, in terms of bosonic and fermionic spectral widths, $Γ_{b}$ and $Γ_{\pm}$. Here, the subscripts $\pm$ correspond to normal and collective (plasmino) excitations of fermions. We study, in particular, the effect of these excitations on thermal properties of $η_{f}[Γ_{\pm}]$. To do this, we determine first the dependence of $Γ_{b}$ and $Γ_{\pm}$ on momentum $p$, temperature $T$, chemical potential $μ$ and $ξ_{0}\equiv m_{b}^{0}/m_{f}^{0}$, in a one-loop perturbative expansion in the orders of the Yukawa coupling. Here, $m_{b}^{0}$ and $m_{f}^{0}$ are $T$ and $μ$ independent bosonic and fermionic masses, respectively. We then numerically determine $η_{b}[Γ_{b}]$ and $η_{f}[Γ_{\pm}]$, and study their thermal properties. It turns out that whereas $Γ_{b}$ and $Γ_{+}$ decrease with increasing $T$ or $μ$, $Γ_{-}$ increases with increasing $T$ or $μ$. This behavior qualitatively changes by adding thermal corrections to $m_{b}^{0}$ and $m_{f}^{0}$, while the difference between $Γ_{+}$ and $Γ_{-}$ keeps increasing with increasing $T$ or $μ$. Moreover, $η_{b}$ ($η_{f}$) increases (decreases) with increasing $T$ or $μ$. We show that the effect of plasminos on $η_{f}$ becomes negligible with increasing (decreasing) $T$ ($μ$).
description: V1: 25 pages, 18 figures; V2: 26 pages, 18 figures. Discussions improved, references added. Version accepted for publication in PRD
City of L'Acide Remediation Case
Publisher: name: Online Ethics Center
Year: 2010
Subjects: Catastrophes, Hazards, Disasters
Corporate Social Responsibility
Environmental Justice
Ethics and Society
Public Health and Safety
Public Well-being
Safety
Social Responsibility
Sustainability

description: This case includes handouts for 4 teams, each with hidden agendas, to be used in class discussion. It is also accompanied by a companion presentation on "The Environmental Implications of Biotechnology." The case concerns the City of L'Acide that has contracted with an engineering firm to remediate a 3 hectare hazardous waste site from an old firing range.
Refined enumeration of noncrossing chains and hook formulas
Creators: name: Josuat-Vergès, Matthieu
Publisher: name: arXiv
Year: 2014
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: In the combinatorics of finite finite Coxeter groups, there is a simple formula giving the number of maximal chains of noncrossing partitions. It is a reinterpretation of a result by Deligne which is due to Chapoton, and the goal of this article is to refine the formula. First, we prove a one-parameter generalization, by the considering enumeration of noncrossing chains where we put a weight on some relations. Second, we consider an equivalence relation on noncrossing chains coming from the natural action of the group on set partitions, and we show that each equivalence class has a simple generating function. Using this we recover Postnikov's hook length formula in type A and obtain a variant in type B.
description: 18 pages. arXiv admin note: substantial text overlap with arXiv:1304.0902
Masses, Decay Constants and Electromagnetic Form-factors with Twisted Boundary Conditions
Creators: name: Bijnens, Johan
name: Relefors, Johan
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Using Chiral Perturbation Theory at one-loop we analyze the consequences of twisted boundary conditions. We point out that due to the broken Lorentz and reflection symmetry a number of unexpected terms show up in the expressions. We explicitly discuss the pseudo-scalar octet masses, axial-vector and pseudo-scalar decay constants and electromagnetic form-factors. We show how the Ward identities are satisfied using the momentum dependent masses and the non-zero vacuum-expectation-values values for the electromagnetic (vector) currents. Explicit expressions at one-loop are provided and an appendix discusses the needed one-loop twisted finite volume integrals.
description: 23 pages, Main changes: New references [6,16] with overlap in results and conclusions added, and a new section describing the interpretation of our results and the relation with earlier results in detail. Other changes: figures changed to be more readable and minor misprints corrected
L'Acide Case Scenario 1: Consulting Firm Engineer
Publisher: name: Online Ethics Center
Year: 2010
Subjects: Catastrophes, Hazards, Disasters
Corporate Social Responsibility
Environmental Justice
Ethics and Society
Public Health and Safety
Safety
Social Responsibility
Sustainability

description: This case includes the point of view of Team 1, the consulting firm engineers, for the L'Acide cleanup case. This case includes handouts for 4 teams, each with hidden agendas, to be used in class discussion.
Using rotation, magnetic activity and lithium to estimate the ages of low mass stars
Creators: name: Jeffries, R. D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The rotation rate, level of magnetic activity and surface lithium abundance are age-dependent quantities in stars of about a solar mass and below. The physical reasons for the evolution of these phenomena are qualitatively understood, but accurate quantitative models remain dependent on empirical calibration using the Sun and stars of known age, chiefly in clusters. In this work I review the status of these "empirical age indicators", outlining the astrophysics of their time dependence, describing the measurements, assessing the precision (and accuracy) of age estimates when applied to individual stars, and identifying their principle limitations in terms of the mass and age ranges over which they are useful. Finally, I discuss the "lithium depletion boundary" technique which, in contrast to the empirical methods, appears to provide robust, almost model-independent ages that are both precise and accurate, but which is only applicable to coeval groups of stars.
description: 38 pages; contribution to the proceedings of the 23rd Evry Schatzman School on Stellar Astrophysics, "The Ages of Stars", Roscoff 2013, EAS Publications Series, eds. C. Charbonnel et al. This version has minor corrections/additions to the bibliography
L'Acide Case Scenario 2: Concerned Citizen
Publisher: name: Online Ethics Center
Year: 2010
Subjects: Catastrophes, Hazards, Disasters
Corporate Social Responsibility
Environmental Justice
Ethics and Society
Public Health and Safety
Safety
Social Responsibility
Sustainability

description: This case includes the point of view of Team 2, the concerned citizens, for the L'Acide cleanup case. This case includes handouts for 4 teams, each with hidden agendas, to be used in class discussion.
Essays in macroeconomic forecasting and model evaluation
Creators: name: Lee, Sungkyung
Publisher: name: No Publisher Supplied
Year: 2018

description: This dissertation studies forecasting model specification, estimation, prediction,and evaluation in big data environments. In an effort to contributeto the discussions of macroeconomic forecasting, I examine the studies offorecasting model specification and forecast accuracy testings and introducenew methodologies in empirical frameworks. The whole set-up of forecastingmodel specification and forecasting evaluation framework is a continuum ofdecisions, which can lead to different forecasting results. In closely-connectedtwo papers, I attempt to empirically evaluate the implications of using differentmethodologies throughout all stages of macro forecasting and provideinsightful conclusions for future researches in the literature.Chapter 2 revisits the question of predictive accuracy testing and modelselection, and asks the question: does the loss function really matter, and if so,what can be gained when utilizing loss function-free model comparison andselection tests? So far in forecasting literature, forecasting results have beencompared based on moment-based approaches which mostly concern aboutonly first and second moment of forecasting errors and require to choose a lossfunction to begin with, which is an additional decisional problem. In Chapter2, I compare forecasting results based on a distributional comparison approachsuggested by Jin et al. (2016), which is technically based on the stochastic dominance principles and loss-function robust. A series of empirical experimentsare carried out using macroeconomic time series data modeled using big datamethods, including a large number of dimension reduction, shrinkage, andmachine learning methods. Analysis and ranking of these methods is foundto depend crucially on whether loss function dependent evaluation of theiraccuracy is carried out, or not.Chapter 3 builds on my first chapter by focusing on the usefulness of so called“supervised” approaches to forecast model selection in big-data environments.When constructing forecasting models using latent factor variablesthat are designed to condense information from large datasets into a small setof useful explanatory variables, standard approaches involve extracting informationrelevant to the entire dataset, and not targeted to a particular variablebeing forecasted. Supervised approaches to model specification do not do this,but instead penalize model specifications according to metrics designed to focuson the particular target variable(s) of interest. In order to evaluate theefficacy of supervised approaches, I carry out Monte Carlo simulations andempirical exercises and empirical results suggest that supervised approachesthat are geared for the purpose of forecasting do serve its own purpose.
L'Acide Case Scenario 3: Environmental Advocate
Publisher: name: Online Ethics Center
Year: 2010
Subjects: Safety
Public Health and Safety
Corporate Social Responsibility
Catastrophes, Hazards, Disasters
Environmental Justice

description: This case includes the point of view of Team 3, the environmental advocacy group, for the L'Acide cleanup case. This case includes handouts for 4 teams, each with hidden agendas, to be used in class discussion.
L'Acide Case Scenario 4: Elected Official
Publisher: name: Online Ethics Center
Year: 2010
Subjects: Safety
Public Health and Safety
Catastrophes, Hazards, Disasters
Corporate Social Responsibility
Environmental Justice
Social Responsibility
Sustainability

description: This case includes the point of view of Team 4, the city council, for the L'Acide cleanup case. This case includes handouts for 4 teams, each with hidden agendas, to be used in class discussion.
Social and Cultural Impact of a Proposed Reservoir on a Rural Kentucky School District
Creators: name: Smith, Charles R.
name: Drucker, Philip
Publisher: name: Kentucky Water Resources Research Institute, University of Kentucky
Year: 1973

description: Abstract:
This study utilizes anthropological concepts and research methods to study the educational system of a Central Kentucky school district with the goal of predicting the impact on it of a proposed multi-purpose (flood control, recreation, etc.) reservoir, and proposing options for forestalling dysfunctional aspects of that impact. The impact will result from the fact that although the county is now rurally oriented, the proposed reservoir will attract (has already begun to attract) urbanite residents from nearby Louisville, Kentucky's largest urban center, who can be expected to bring urban values concerning education, as well as other areas. To assess probable directions of change, a school in an upper middle class suburb of Louisville, the sort of milieu from which most new residents will come, was also studied. This research is another step in the program "Anthropological analysis of sociocultural benefits and costs of stream-control devices."
Funding information: The work on which this report is based was supported in part by funds provided by the Office of Water Resources Research, United States Department of the Interior, as authorized under the Water Resources Research Act of 1964.
Kernel interpolation of acoustic transfer functions with adaptive kernel for directed and residual reverberations
Creators: name: Ribeiro, Juliano G. C.
name: Koyama, Shoichi
name: Saruwatari, Hiroshi
Publisher: name: arXiv
Year: 2023
Subjects: subject: Audio and Speech Processing (eess.AS)
subject: Sound (cs.SD)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: An interpolation method for region-to-region acoustic transfer functions (ATFs) based on kernel ridge regression with an adaptive kernel is proposed. Most current ATF interpolation methods do not incorporate the acoustic properties for which measurements are performed. Our proposed method is based on a separate adaptation of directional weighting functions to directed and residual reverberations, which are used for adapting kernel functions. Thus, the proposed method can not only impose constraints on fundamental acoustic properties, but can also adapt to the acoustic environment. Numerical experimental results indicated that our proposed method outperforms the current methods in terms of interpolation accuracy, especially at high frequencies.
description: To appear in ICASSP 2023
So, have you heard about this thing called ChatGPT? A Data Science point of view
Creators: name: Handcock, Rebecca N
Publisher: name: Zenodo
Year: 2023
Subjects: Data Science
Generative AI
ChatGPT

description: This presentation and a following panel were part of the event: "So, have you heard about this thing called ChatGPT?" Thursday, 30th March 2023 Locations: University of Sydney Business School and online via Zoom Description "You are invited to an open, provocative, and interactive forum about ChatGPT, the issues and myths around it-and how it might become a part of all our teaching and learning future (and present). The forum is presented by the University of Sydney Business School This thought-provoking panel of leading experts and practitioners will discuss and debate the influence ChatGPT and other types of generative AI on how we teach and learn at the Business School, and how AI may shape your future career. The session will be highly interactive and will make you think about your own higher education learning experience inside and outside the classroom and what the skills of using AI might mean for your future career."
Lipid Organization by the Caveolin-1 complex
Creators: name: Liebl
Publisher: name: Zenodo
Year: 2024

description: PLUM.dat is input file for Metadynamics simulations.

 

cav1_cg_now.gro is Martini output structure

 

step6.1_min_now.gro is atomistic structure backmapped from coarse-grained.
title: Using an Evidence Based Practice Informatics Safety Intervention to Improve Medication Safety among Community Dwelling Older Adults
Creators: name: LeBlanc, Raeann Genevieve
Publisher: name: eScholarship@UMMS
Year: 2013

description: Medication safety and prevention of medication related problems are important issues in promoting and maintaining health and safety in one’s home for community dwelling older adults. Assessment of medications and management of a medication schedule are essential elements of medication safety, medication review, and medication care coordination. The Framework for Geriatric Homecare Excellence (Collaboration for Home Care Advances and Practices, 2009) is used as the foundation of this project to improve medication management, and promote and maintain health and safety at home. An in-home medication assessment was completed, using a medication management software informatics system to review medications, identify medication related problems, and convey this information to the Primary Care Provider, case manager, and client. Evidence based patient-centered educational interventions on management and understanding of medications were provided to participants to emphasize the correct use of medications and use of a personal medication record. The goal of this health promotion and health maintenance project was to improve medication safety through focused assessment and medication related education interventions for community dwelling older adults. This informatics based medication safety intervention showed considerable strength in completing and sharing medication home assessments enhanced by the software abilities. Significant outcome improvements were associated with the pre-post test comparison in provision of an up-to-date medication list and comprehension by clients of specific medication safety education.
Optimal scheduling of park-level integrated energy system considering ladder-type carbon trading mechanism and flexible load
Creators: name: Sun, Hongbin
name: Sun, Xinmei
name: Kou, Lei
name: Zhang, Benfa
name: Zhu, Xiaodan
Publisher: name: arXiv
Year: 2023
Subjects: subject: Systems and Control (eess.SY)
subject: Computational Engineering, Finance, and Science (cs.CE)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences
subject: K.1
subject: 68T30

description: In an attempt to improve the utilization efficiency of multi-energy coupling in park-level integrated energy system (PIES), promote wind power consumption and reduce carbon emissions, a low-carbon economic operation optimization model of PIES integrating flexible load and carbon trading mechanism is constructed. Firstly, according to the characteristics of load response, the demand response is divided into four types: which can be shifted, transferred, reduced and replaced. Secondly, the PIES basic architecture is given by considering the combined heat and power generation coupling equipment, new energy and flexible load in the park. Finally, introducing the ladder-type carbon trading mechanism into the system and minimize the total operating cost, the low-carbon economic operation optimization model of PIES is established. The YALMIP toolbox and CPLEX solver are used to solve the example, the simulation results show that the participation of electrical and thermal coupled scheduling and flexible electric or thermal loads can significantly reduce the system operating cost, reduce the load peak-to-valley difference and relieve peak power consumption pressure.
description: accepted by Energy Reports
title: Expression of the Integrin Beta 8 Gene (ITGB8) in Epicardial Adipose Tissue is Highly and Directly Correlated with the Degree of Coronary Atherosclerosis
Creators: name: Lee, Nancy
name: Nicoloro, Sarah M.
name: Straubhaar, Juerg R.
name: Darrigo, Melinda
name: Tam, Stanley
name: Czech, Michael P.
name: Fitzgibbons, Timothy P.
Publisher: name: eScholarship@UMMS
Year: 2013

description: Background: In patients with coronary artery disease (CAD), epicardial adipose tissue (EAT) expression of inflammatory genes is high while expression of anti-inflammatory genes is low. We hypothesized that expression of certain genes in EAT would correlate directly with the degree of adjacent CAD.

Methods: EAT and paired subcutaneous adipose tissue (SAT) samples were collected from cardiac surgery patients (n=9) with and without CAD. RNA was isolated and hybridized to Affymetrix 1.0 ST chips. Genes differentially expressed in EAT vs. SAT were identified. Probe intensities were correlated with the severity of CAD in each patient using the Gensini score.

Results: 35 genes were differentially expressed in EAT at >3.0 fold change (p

Conclusions: Expression of ITGB8 is directly correlated with CAD severity. ITGB8 has been previously shown to be expressed by fibroblasts and functions to activate TGFβ. TGFβ signaling has also been correlated with advanced atherosclerosis. We speculate that EAT expression of ITGB8 may have pro-inflammatory effects, possibly by activating TGFβ, and stimulating recruitment of dendritic cells or T cells to secondary lymphoid organs in EAT. Whether or not this is the case is a goal of future studies.
Total variation regularization for manifold-valued data
Creators: name: Weinmann, Andreas
name: Demaret, Laurent
name: Storath, Martin
Publisher: name: arXiv
Year: 2013
Subjects: subject: Optimization and Control (math.OC)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Medical Physics (physics.med-ph)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences
subject: 65K05, 65K10, 68U10, 94A08

description: We consider total variation minimization for manifold valued data. We propose a cyclic proximal point algorithm and a parallel proximal point algorithm to minimize TV functionals with $\ell^p$-type data terms in the manifold case. These algorithms are based on iterative geodesic averaging which makes them easily applicable to a large class of data manifolds. As an application, we consider denoising images which take their values in a manifold. We apply our algorithms to diffusion tensor images, interferometric SAR images as well as sphere and cylinder valued images. For the class of Cartan-Hadamard manifolds (which includes the data space in diffusion tensor imaging) we show the convergence of the proposed TV minimizing algorithms to a global minimizer.
Spontaneous symmetry breaking in dual-core baby-Skyrmion systems
Creators: name: Malomed, Boris A.
name: Shnir, Yakov
name: Zhilin, Gleb
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We introduce a system composed of two (2+1)-dimensional baby-skyrmion models (BSMs) set on parallel planes and linearly coupled by tunneling of fields. This system can be realized in a dual-layer ferromagnetic medium. Unlike dual-core models previously studied\ in nonlinear optics and BEC, here the symmetry-breaking bifurcation (SBB) in solitons (baby skyrmions) occurs with the increase of the inter-core coupling ($κ$), rather than with its decrease, due to the fact that even in the uncoupled system neither core may be empty. Prior to the onset of the symmetry breaking between the two components of the solitons, they gradually separate in the lateral direction, due to the increase of $κ$, which is explained in an analytical form by means of an effective interaction potential. Such evolution scenario are produced for the originally symmetric states with topological charges in the two cores $\left(B^{(1)},B^{(2)}\right)$, with $% B^{(1)}=B^{(2)}=1,2,3,4$. The evolution of mixed states, of the $\left(1,2\right)$ and $\left(2,4\right)$ types, with the variation of $κ$ is studied too.
description: 17 pages, 18 figures, clarifications and a reference added; final version appearing in PRD
title: Three Measures of Tobacco Dependence Independently Predict Changes in Neural Structure
Creators: name: King, Jean A.
name: Ursprung, W. W. Sanouri A.
name: DiFranza, Joseph R.
name: Huang, Wei
name: Zhang, Nanyin
name: Kennedy, David N.
name: Ziedonis, Douglas M.
Publisher: name: eScholarship@UMMS
Year: 2013

description: Studies have demonstrated moderate correlations between fractional anisotropy (FA, a measure of white matter organization), and Fagerström Test for Nicotine Dependence (FTND) scores in various white matter brain structures (r=-.52 to -.64). FA increases with smoking in adolescents, but in adult smokers FA declines with the progression of physical dependence. We examined correlations between FA and 3 measures of tobacco dependence: the FTND, Levels of Physical Dependence (PD), and the Hooked on Nicotine Checklist (HONC). The latter 2 measures assess only symptoms rather than behaviors, based on an assumption that a direct assessment of subjective symptoms will better reflect underlying biological conditions than behaviors that might be constrained by sociocultural factors.We compared white matter FA in 8 smokers and 10 nonsmokers and plotted the location of maximal correlation between FA and each dependence measure. FA trended higher in smokers than nonsmokers in the anterior cingulum bundle (ACb) (p=0.05). Among smokers, plots of the maximal correlation for all 3 measures fell within a circumscribed area of the left ACb, showing excellent concordance of results across measures. The maximal correlation with FA was r= -.78 for the FTND, -.85 for Levels of PD, and -.96 for the HONC (p<0.05). These data suggest that subjective symptoms reflect the underlying biology better than behavior does. The reliability and validity of the HONC measure is supported by its excellent correlation with FA. The rapid development of HONC symptoms implies that changes in neural density begin with the first cigarettes. This conclusion is supported by other studies showing a significant increase in tissue density in the cingulate cortex; a trend in the same direction in the nucleus accumbens and prefrontal cortex in rats that had received 4 doses of nicotine; and dendritic proliferation among rats in the latter two structures.
On Binary Driven Hypernovae and their nested late X-ray emission
Creators: name: Ruffini, R.
name: Muccino, M.
name: Bianco, C. L.
name: Enderli, M.
name: Izzo, L.
name: Kovacevic, M.
name: Penacchioni, A. V.
name: Pisani, G. B.
name: Rueda, J. A.
name: Wang, Y.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Context: The induced gravitational collapse (IGC) paradigm addresses the very energetic (10^{52}-10^{54}erg) long gamma-ray bursts (GRBs) associated to supernovae (SNe). Unlike the traditional "collapsar" model, an evolved FeCO core with a companion neutron star (NS) in a tight binary system is considered as the progenitor. This special class of sources, here named "binary driven hypernovae" (BdHNe), presents a composite sequence composed of four different episodes [...]. Aims: We first compare and contrast the steep decay, the plateau and the power-law decay of the X-ray luminosities of three selected BdHNe [...]. Second, to explain the different sizes and Lorentz factors of the emitting regions of the four Episodes, [...]. Finally, we show the possible role of r-process, which originates in the binary system of the progenitor.. Methods: We compare and contrast the late X-ray luminosity of the above three BdHNe. We examine correlations between the time at the starting point of the constant late power-law decay, t^*_a, the average prompt luminosity, , and the luminosity at the end of the plateau, L_a. We analyze a thermal emission (~0.97-0.29 keV), observed during the X-ray steep decay phase of GRB 090618. Results: The late X-ray luminosities of the three BdHNe [...] show a precisely constrained "nested" structure [...]. Conclusions: We confirm a constant slope power-law behavior for the late X-ray luminosity in the source rest-frame, which may lead to a new distance indicator for BdHNe. These results, as well as the emitter size and Lorentz factor, appear to be inconsistent with the traditional afterglow model based on synchrotron emission from an ultra-relativistic [...] collimated jet outflow. We argue, instead, for the possible role of r-process, originating in the binary system, to power the mildly relativistic X-ray source.
description: 4 pages, 4 figures, to appear on A&A. New version slightly modified to match the one in press
title: Cluster Randomized Trials and Statistical Power
Creators: name: Lauer, Stephen A.
name: Reich, Nicholas G.
Publisher: name: eScholarship@UMMS
Year: 2013

description: The cluster-randomized trial (CRT) is a common study design in public health research. In situations where dividing a group of individuals into treatment and controls is unethical or impossible, a CRT design maintains the strengths of a randomized study design. By comparing the outcomes of small populations (clusters), we can observe the impacts of interventions on the community as a whole. Public health researchers around the world have utilized CRTs to measure the effect of, for example, de-worming medication on school attendance, financial incentives on doctor absenteeism, and providing chlorine to waterholes.

The CRT can be a potent tool, however it is not without flaws. As with an individually randomized trial, it often requires a large sample size (i.e. many clusters) to achieve adequate levels of power for its results. Existing formulas to estimate power for a study design frequently rely on simplifications of the study design. Addressing common challenges that researchers face when calculating power – such as variability in cluster sizes and uncertainty in between-cluster variability – we illustrate how these features affect power and demonstrate the utility of a simulation-based power calculation methodology.

Using R and the clusterPower package, we conducted a simulation study to quantify how variability in cluster size can influence the statistical power of a study. From this study, we provide concrete guidelines that can assist in the design phase of future CRTs, whether for testing a vaccine in Thailand or legislation in America.
A ballistic two-dimensional-electron-gas Andreev interferometer
Creators: name: Amado, M.
name: Fornieri, A.
name: Biasiol, G.
name: Sorba, L.
name: Giazotto, F.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We report the realization and investigation of a ballistic Andreev interferometer based on an InAs two dimensional electron gas coupled to a superconducting Nb loop. We observe strong magnetic modulations in the voltage drop across the device due to quasiparticle interference within the weak-link. The interferometer exhibits flux noise down to $\sim 80\, μΦ_0/\sqrt{\textrm{Hz}}$, and a robust behavior in temperature with voltage oscillations surviving up to $\sim7\,$K. Besides this remarkable performance, the device represents a crucial first step for the realization of a fully-tunable ballistic superconducting magnetometer and embodies a potential new platform for the investigation of Majorana bound states as well as non-local entanglement of Cooper pairs.
description: 4+ pages, 4 color figures
title: Regulation of Androgen Receptor Co-Regulators by Activation of the CXCL12/CXCR4 Axis: A Microarray and Proteomics Approach
Creators: name: Kasina, Sathish
name: Begley, Lesa
name: Remmer, Henriette
name: Macoska, Jill A.
Publisher: name: eScholarship@UMMS
Year: 2013

description: Background: Activation of the CXCL12/CXCR4 axis is known to stimulate androgen-independent activation of the androgen receptor (AR) in the LNCaP prostate cancer cell line. In the present study, the CXCL12-stimulated expression profile of androgen responsive genes (ARGs) and AR:co-regulator protein:protein interactions has been identified by microarray and proteomic analysis, respectively.

Methods: To directly identify proteins that interacted with the AR in response to CXCL12 stimulation, LNCaP cells treated with CXCL12 were subjected to a total proteomics analysis after co-immunoprecipitation (co-IP) with anti-AR antibody. AR- interacting proteins from co-IP were pre-fractionated by SDS-PAGE, in-gel trypsin digested, and analyzed by liquid chromatography coupled to MS (nanoLC-MS/MS). Acquired MS2 data was searched using MASCOT against a SWISSProt human database. Detected proteins were analyzed by spectral counting to qualitatively determine significant changes in protein expression.

Results: Gene expression profiling and proteomics analysis of CXCL12-treated LNCaP cells indicated a robust regulation of ARGs, including known AR co-regulators and/or AR-interacting proteins. All known AR co-regulators were extracted and segregated according to their molecular function. GTF2 (Transcription factor), ARID1A (Chromatin Remodeling complex component) and PRDX1 (other function) are the AR co-regulators which showed greater than two fold more interaction with AR in response to CXCL12 treatment, and HNRNPD (Splicing and RNA metabolism) is the protein which is commonly differentially regulated in both microarray and proteomic analysis in response to CXCL12 treatment. The potential role of the above AR co-regulators in promoting the CXCL12- mediated and androgen-independent AR activation and hence the prostate cancer is yet to be elucidated.

Conclusions: These data shed new light into the role of ARGs and/or AR Co-regulators in CXCL12- mediated androgen independent activation of AR and suggests new therapeutic targets for the treatment of castration-resistant prostate cancers.
Resting-state functional connectivity and depression
Creators: name: Lesnewich, Laura Marie
Publisher: name: No Publisher Supplied
Year: 2018

description: Depressive disorders are heterogeneous and their diagnoses have poor reliability. There is a need to understand the biological mechanisms of depression to improve assessment, diagnosis, and treatment. The default mode network (DMN), central executive network (CEN), and salience network (SN) are large-scale neural networks that have been implicated in depression. The present study examined how resting-state functional connectivity within and between these three networks is associated with individual differences in depression severity as well as rumination and emotion dysregulation, two transdiagnostic features associated with depression. Data were collected via functional magnetic resonance imaging (fMRI) using a standard resting- state paradigm. Resting-state data for n = 59 participants were analyzed using independent component analysis. Functional connectivity values between core nodes of the DMN, CEN, and SN were calculated using Pearson correlation, and these connectivity values were correlated to continuous measures of depression severity, rumination, and emotion dysregulation across the whole sample. Functional connectivity between the right dorsolateral prefrontal cortex (CEN) and paracingulate gyrus (CEN) was positively correlated (p < 0.05) to depression severity. Functional connectivity between the left dorsolateral prefrontal cortex (CEN) and left inferior parietal lobule (DMN) was negatively correlated (p < 0.05) to depression severity. These associations were no longer significant after correction for multiple comparisons. Each pair of brain regions was additionally correlated to a distinct pattern of rumination and emotion dysregulation scores. If replicated, the present findings could add knowledge about how resting-state functional connectivity varies with individual differences in depression severity and related constructs.
title: A Pilot Study of a Modified Acceptance and Commitment Therapy Smoking Cessation Treatment for Veterans with PTSD
Creators: name: Kelly, Megan M.
name: Forsyth, John
name: Ziedonis, Douglas M.
name: Kalman, David
name: Cooney, Judith
Publisher: name: eScholarship@UMMS
Year: 2013

description: Veterans with posttraumatic stress disorder (PTSD) have high rates of smoking and significant difficulties with quitting. Acceptance and mindfulness-based techniques may enhance smoking cessation approaches for veterans with PTSD as they are designed to improve emotion regulation skills related to coping with elevated negative affect and withdrawal symptoms associated with quit attempts. Veterans with current PTSD and smoking ≥ 15 cigarettes/day (N=19) participated in an open trial of Acceptance and Commitment Therapy for Veterans with PTSD and Tobacco Use (ACT-PT). Participants attended nine weekly individual counseling sessions and received eight weeks of the nicotine patch. Primary outcomes included expired-air carbon monoxide confirmed seven-day point prevalence abstinence, number of cigarettes/day at the end of treatment, and PTSD symptoms on the PTSD Checklist (PCL). Intent-to-treat analyses examined pre-treatment to post-treatment scores on the PCL. At the end of treatment (one month after targeted quit date), 37% (7/19) of participants were abstinent from smoking, 37% (7/19) were abstinent from smoking at the one month follow-up, and 16% (3/19) were abstinent at the three month follow-up. Subjects reduced from 26 cigarettes/day at baseline to 10 cigarettes/day at the end of treatment (p<.001), and 15 cigarettes/day at the 3-month follow-up (p=.002). PTSD symptoms significantly decreased from baseline to the end of treatment (p<.001), and continued to remain significantly decreased at the 3-month follow-up (p=.011). The retention rate (74%), client satisfaction ratings and qualitative feedback from subjects indicated that the treatment was acceptable. Although preliminary, these results suggest that ACT-PT is a promising smoking cessation treatment for veterans with PTSD. Longer follow-up and randomized controlled studies are needed.
A Prospect of Earthquake Prediction Research
Creators: name: Ogata, Yosihiko
Publisher: name: arXiv
Year: 2013
Subjects: subject: Methodology (stat.ME)
subject: Geophysics (physics.geo-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: Earthquakes occur because of abrupt slips on faults due to accumulated stress in the Earth's crust. Because most of these faults and their mechanisms are not readily apparent, deterministic earthquake prediction is difficult. For effective prediction, complex conditions and uncertain elements must be considered, which necessitates stochastic prediction. In particular, a large amount of uncertainty lies in identifying whether abnormal phenomena are precursors to large earthquakes, as well as in assigning urgency to the earthquake. Any discovery of potentially useful information for earthquake prediction is incomplete unless quantitative modeling of risk is considered. Therefore, this manuscript describes the prospect of earthquake predictability research to realize practical operational forecasting in the near future.
description: Published in at http://dx.doi.org/10.1214/13-STS439 the Statistical Science (http://www.imstat.org/sts/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Data for "Chromosome-scale genome assembly of the freshwater snail Semisulcospira habei from the Lake Biwa drainage system"
Creators: name: Miura, Osamu
name: Toyoda, Atsushi,
name: Sakurai, Tetsuya
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 310405
subject: Evolutionary ecology

description: Genome sequence assembly dataset of Semisulcospira habei with the list of protein-coding genes determined by the software Braker2.
Influence of the substrate on the diffusion coefficient and the momentum relaxation in graphene: the role of surface polar phonons
Creators: name: Rengel, Raúl
name: Pascual, Elena
name: Martin, María J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Knowing the influence of the substrate type on the diffusion coefficient and the momentum relaxation in graphene is of great importance for the development of new device models specifically adapted to the peculiarities of this material. In this work, the influence of surface polar phonons at low and high electric fields is evaluated by means of ensemble Monte Carlo simulations for several types of substrates. The results show that at low fields surface polar phonons have a major role on reducing the scattering time, breaking the correlation of velocity fluctuations and degrading the diffusion coefficient. At high fields the differences with regard to suspended samples in terms of diffusivity and momentum relaxation tend to reduce, providing at the same time larger saturation velocities, particularly for h-BN.
description: 10 pages, 5 figures Typographical errors corrected; journal reference included
Fred Cuny (1944-1995) -- Disaster Relief Innovator
Publisher: name: Online Ethics Center
Year: 2006
Subjects: Human Rights
Catastrophes, Hazards, Disasters
Sustainable Development

description: Fred Cuny was a disaster relief specialist who used his training in engineering to do humanitarian work. He worked in countries such as Biafra, Guatemala, Ethiopia, Iraq, Somalia, and Bosnia. In March 1995, he disappeared in Chechnya and was never found. The story of his work is told in 8 sections and includes supplementary materials and pictures.
Unification and Logarithmic Space
Creators: name: Aubert, Clément
name: Bagnol, Marc
Publisher: name: arXiv
Year: 2014
Subjects: subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences

description: We present an algebraic characterization of the complexity classes Logspace and NLogspace, using an algebra with a composition law based on unification. This new bridge between unification and complexity classes is inspired from proof theory and more specifically linear logic and Geometry of Interaction. We show how unification can be used to build a model of computation by means of specific subalgebras associated to finite permutations groups. We then prove that whether an observation (the algebraic counterpart of a program) accepts a word can be decided within logarithmic space. We also show that the construction can naturally represent pointer machines, an intuitive way of understanding logarithmic space computing.
Working Ethics into The Conversation: Professional Responsibility in Engineering
Publisher: name: Online Ethics Center
Year: 2019
Subjects: Pedagogical Approaches

description: Dr. Michael Loui, professor emeritus of electrical and computer engineering, University of Illinois at Urbana-Champaign, talked on the subject of "What Is Professional Responsibility in Engineering?" He was joined by discussant Dr. Jeff Brown, associate professor of civil engineering at Embry-Riddle Aeronautical University and Dr. Rosalyn Berne, Director of the NAE's Center for Engineering Ethics and Society.
title: Maltoheptaose Promotes Nanoparticle Internalization by Escherichia coli
Creators: name: Jayawardena, H. Surangi N.
name: Jayawardana, Kalana W.
name: Chen, Xuan
name: Yan, Mingdi
Publisher: name: eScholarship@UMMS
Year: 2013

description: Nanoparticles conjugated with D-maltoheptaose (G7) showed a striking increase in the surface adherence and internalization by E. coli. This applies to silica nanoparticles (SNP), magnetic nanoparticles (MNP), silica-coated magnetic nanoparticles (SMNP) and silica-coated quantum dots (SQDs) ranging from a few to over a hundred nanometers in size, as well as wild type E. coli ATCC 33456, ORN 178, ORN 208 with the maltodextrin transport channel and the LamB mutant JW 3392-1 (Fig. 1). TEM images including the thin section samples revealed the uptake of nanoparticles in cell walls and inside the cytoplasm (Fig. 2). Unfunctionalized nanoparticles and nanoparticles functionalized with β-cyclodextrin (CD) showed little or no binding to the E. coli cell surface, and no obvious internalization of the nanoparticles was observed. D-Mannose-functionalized nanoparticles bound to the pili of E. coli ORN 178 through the well-known Man-binding lectin (FimH) rather than cell internalization. Surface ligands that can improve the uptake of nanomaterials to bacterial cells should provide a powerful means of targeting a payload delivery to a potential disease causing strain. Work is underway to develop nanomaterial delivery systems for multidrug resistance bacteria.
Final Report on Citizen Science at School
Creators: name: Cigarini, Anna
name: Bonhoure, Isabelle
name: Vicens, Julian
name: Perelló, Josep
Publisher: name: Zenodo
Year: 2019
Subjects: Citizen Science
Education
School
Co-creation
Social Sciences
Game Theory

description: In this final report on Citizen Science at School, we have summarized the main outcomes of

the introduction of Citizen Science in the classroom in the frame of the H2020 project STEMForYouth.

While analyzing the results of this 30 months process to introduce Citizen Science at school in a

radical and completely new manner, the goal of this report is to provide short and concise bullet

points, so that the report can have a practical use for teachers and scientists willing to follow the same methodology and replicate the

process. For this reason, we privileged short texts and graphic visualizations of the contents in order to foster a wider dissemination.