cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1
Creators: name: Huang, Xi Ping
name: Liu, Feng
name: Vedadi, Masoud
name: Konze, Kyle D.
name: Arrowsmith, Cheryl H.
name: Wang, Gang Greg
name: James, Lindsey I.
name: Jiang, Alice
name: Jin, Jian
name: Brown, Peter J.
name: Ma, Anqi
name: Rougie, Marie
name: Kuznetsova, Ekaterina
name: MacNevin, Christopher J.
name: Parton, Trevor
name: Roth, Bryan L.
name: Gao, Cen
name: Norris, Jacqueline L.
name: Li, Fengling
name: Pattenden, Samantha G.
name: Hahn, Klaus M.
name: Frye, Stephen V.
name: Barsyte-Lovejoy, Dalia
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: EZH2 or EZH1 is the catalytic subunit of the polycomb repressive complex 2 that catalyzes methylation of histone H3 lysine 27 (H3K27). The trimethylation of H3K27 (H3K27me3) is a transcriptionally repressive post-translational modification. Overexpression of EZH2 and hypertrimethylation of H3K27 have been implicated in a number of cancers. Several selective inhibitors of EZH2 have been reported recently. Herein we disclose UNC1999, the first orally bioavailable inhibitor that has high in vitro potency for wild-type and mutant EZH2 as well as EZH1, a closely related H3K27 methyltransferase that shares 96% sequence identity with EZH2 in their respective catalytic domains. UNC1999 was highly selective for EZH2 and EZH1 over a broad range of epigenetic and non-epigenetic targets, competitive with the cofactor SAM, and non-competitive with the peptide substrate. This inhibitor potently reduced H3K27me3 levels in cells and selectively killed diffused large B cell lymphoma cell lines harboring the EZH2Y641N mutant. Importantly, UNC1999 was orally bioavailable in mice, making this inhibitor a valuable tool for investigating the role of EZH2 and EZH1 in chronic animal studies. We also designed and synthesized UNC2400, a close analog of UNC1999 with >1,000-fold lower potency than UNC1999 as a negative control for cell-based studies. Finally, we created a biotin-tagged UNC1999 (UNC2399) which enriched EZH2 in pull-down studies, and a UNC1999 – dye conjugate (UNC2239) for co-localization studies with EZH2 in live cells. Taken together, these compounds represent a set of useful tools for the biomedical community to investigate the role of EZH2 and EZH1 in health and disease.
title: Calcified desmoplastic fibroblastoma of the foot: imaging findings
Creators: name: Urigo, Carlo
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cancer
subject: Education
subject: Ultrasound-Colour Doppler
subject: MR
subject: Conventional radiography
subject: Musculoskeletal soft tissue

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Discuss the appearance of the desmoplastic fiboblastoma (DF) at standard radiographs, ultrasound (US) and magnetic resonance imaging...
On the Feasibility of Wireless Energy Transfer Using Massive Antenna Arrays
Creators: name: Kashyap, Salil
name: Björnson, Emil
name: Larsson, Erik G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: We illustrate potential benefits of using massive antenna arrays for wireless energy transfer (WET). Specifically, we analyze probability of outage in WET over fading channels when a base station (BS) with multiple antennas beamforms energy to a wireless sensor node (WSN). Our analytical results show that by using massive antenna arrays, the range of WET can be increased for a given target outage probability. We prove that by using multiple-antenna arrays at the BS, a lower downlink energy is required to get the same outage performance, resulting into savings of radiated energy. We show that for energy levels used in WET, the outage performance with least-squares or minimum mean-square error channel estimates is same as that obtained based on perfect channel estimates. We observe that a strong line-of-sight component between the BS and WSN lowers outage probability. Furthermore, by deploying more antennas at the BS, a larger energy can be transferred reliably to the WSN at a given target outage performance for the sensor to be able to perform its main tasks. In our numerical examples, the RF power received at the input of the sensor is assumed to be on the order of a mW, such that the rectenna operates at an efficiency in the order of 50 %.
description: To appear in IEEE Trans. Wireless Communication, 2016 (14 pages, 10 figures)
Identification and ranking of key factors influencing the effectiveness of information systems in State-Owned Organizations
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2017

description: Nowadays, information systems organizations can help in gaining competitive advantage, because the quality of the output of these systems play an important role in improving the performance of the organization. The main objective of this study is Identification and ranking of key factors influencing the effectiveness of information systems in State-Owned Organizations. For this purpose, the role of variables such as organizational factors, human factors and technical factors have been examined.The Statistical Population of this research is IT experts one of the organizers of public sector. In this study, data were analyzed with using SPSS and  fuzzy analytic hierarchy process. The results suggest that organizational, human and technical factors in order of priority  are influential on effectiveness of information systems. Senior management support, security, Adoption of Information Technology and knowledge management, are indicators that affect the effectiveness of information systems.
MPEC 2024-R181 : COMET C/2024 Q3 (PANSTARRS)
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: COMET C/2024 Q3 (PANSTARRS)

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Conformation Guides Molecular Efficacy in Docking Screens of Activated β-2 Adrenergic G Protein Coupled Receptor
Creators: name: Weiss, Dahlia R.
name: Kleist, Andrew
name: Zhu, Xiao
name: Roth, Bryan L.
name: Shoichet, Brian K.
name: Ahn, Seungkirl
name: Lefkowitz, Robert J.
name: Strachan, Ryan
name: Sassano, Maria F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: A prospective, large library virtual screen against an activated β2-adrenergic receptor (β2AR) structure returned potent agonists to the exclusion of inverse-agonists, providing the first complement to the previous virtual screening campaigns against inverse-agonist-bound G protein coupled receptor (GPCR) structures, which predicted only inverse-agonists. In addition, two hits recapitulated the signaling profile of the co-crystal ligand with respect to the G protein and arrestin mediated signaling. This functional fidelity has important implications in drug design, as the ability to predict ligands with predefined signaling properties is highly desirable. However, the agonist-bound state provides an uncertain template for modeling the activated conformation of other GPCRs, as a dopamine D2 receptor (DRD2) activated model templated on the activated β2AR structure returned few hits of only marginal potency.
title: Imaging modalities before ESWL and the treatment's efficacy in pediatric patients with upper urinary tract stone disease
Creators: name: Potcoava, Dalma
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Paediatric
subject: Kidney
subject: Ultrasound
subject: Conventional radiography
subject: Lithotripsy
subject: Efficacy studies
subject: Calcifications / Calculi

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Living in a consumer society urolithiasis is showing an increase incidence among adults and in children too, due to lifestyle- associated factors and different eating habits. ESWL is the least- invasive procedure for stone management in...
(101235) Frederick Monkman Driver
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Prevalence, management and clinical relevance of intra and extracranial cystic lesions from a radiologist’s perspective.
Creators: name: Ezhapilli, Sajeev
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cysts
subject: Education
subject: MR
subject: CT
subject: Neuroradiology spine
subject: Neuroradiology brain

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Cystic lesions are frequently encountered by neuroradiologists. Recognizing these entities based on imaging findings and clinical presentation is essential for the appropriate diagnosis and treatment considerations. Here we hope to provide...
(101236) Charles Edward Tricks
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Exploring a 2-Naphthoic Acid Template for the Structure-Based Design of P2Y 14 Receptor Antagonist Molecular Probes
Creators: name: Weitzer, Clarissa D.
name: Harden, T. Kendall
name: Brown, Kyle A.
name: Stevens, Raymond C.
name: Jacobson, Kenneth A.
name: Barrett, Matthew O.
name: Zhao, Qiang
name: Katritch, Vsevolod
name: Paoletta, Silvia
name: Yin, Andrew L.
name: Hammes, Eva
name: Kiselev, Evgeny
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The P2Y14 receptor (P2Y14R), one of eight P2Y G protein-coupled receptors (GPCR), is involved in inflammatory, endocrine, and hypoxic processes and is an attractive pharmaceutical target. The goal of this research is to develop high-affinity P2Y14R fluorescent probes based on the potent and highly selective antagonist 4-(4-(piperidin-4-yl)-phenyl)-7-(4-(trifluoromethyl)-phenyl)-2-naphthoic acid (6, PPTN). A model of hP2Y14R based on recent hP2Y12R X-ray structures together with simulated antagonist docking suggested that the piperidine ring is suitable for fluorophore conjugation while preserving affinity. Chain-elongated alkynyl or amino derivatives of 6 for click or amide coupling were synthesized, and their antagonist activities were measured in hP2Y14R-expressing CHO cells. Moreover, a new Alexa Fluor 488 (AF488) containing derivative 30 (MRS4174, Ki = 80 pM) exhibited exceptionally high affinity, as compared to 13 nM for the alkyne precursor 22. A flow cytometry assay employing 30 as a fluorescent probe was used to quantify specific binding to P2Y14R. Known P2Y receptor ligands inhibited binding of 30 with properties consistent with their previously established receptor selectivities and affinities. These results illustrate that potency in this series of 2-naphthoic acid derivatives can be preserved by chain functionalization, leading to highly potent fluorescent molecular probes for P2Y14R. Such conjugates will be useful tools in expanding the SAR of this receptor, which still lacks chemical diversity in its collective ligands. This approach demonstrates the predictive power of GPCR homology modeling and the relevance of newly determined X-ray structures to GPCR medicinal chemistry.
Identification of a Fragment-like Small Molecule Ligand for the Methyl-lysine Binding Protein, 53BP1
Creators: name: Cui, Gaofeng
name: Frye, Stephen V.
name: Janzen, William P.
name: Perfetti, Michael T.
name: James, Lindsey I.
name: Rothbart, Scott B.
name: Dickson, Bradley M.
name: Mader, Pavel
name: Dong, Aiping
name: McBride, Kevin M.
name: Mer, Georges
name: Mu, Yunxiang
name: Strahl, Brian D.
name: Norris, Jacqueline L.
name: Baughman, Brandi M.
name: Arrowsmith, Cheryl H.
name: Brown, Peter J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Improving our understanding of the role of chromatin regulators in the initiation, development, and suppression of cancer and other devastating diseases is critical, as they are integral players in regulating DNA integrity and gene expression. Developing small molecule inhibitors for this target class with cellular activity is a crucial step toward elucidating their specific functions. We specifically targeted the DNA damage response protein, 53BP1, which uses its tandem tudor domain to recognize histone H4 dimethylated on lysine 20 (H4K20me2), a modification induced by double-strand DNA breaks. Through a cross-screening approach we identified UNC2170 (1) as a micromolar ligand of 53BP1, which demonstrates at least 17-fold selectivity for 53BP1 as compared to other methyl-lysine (Kme) binding proteins tested. Structural studies revealed that the tert-butyl amine of UNC2170 anchors the compound in the methyl-lysine (Kme) binding pocket of 53BP1, making it competitive with endogenous Kme substrates. X-ray crystallography also demonstrated that UNC2170 binds at the interface of two tudor domains of a 53BP1 dimer. Importantly, this compound functions as a 53BP1 antagonist in cellular lysates and shows cellular activity by suppressing class switch recombination, a process which requires a functional 53BP1 tudor domain. These results demonstrate that UNC2170 is a functionally active, fragment-like ligand for 53BP1.
Additional file 3 of A comparative analysis of histologic types of thyroid cancer between career firefighters and other occupational groups in Florida
Creators: name: Ogunsina, Kemi
name: Koru-Sengul, Tulay
name: Rodriguez, Valentina
name: Caban-Martinez, Alberto J.
name: Schaefer-Solle, Natasha
name: Ahn, Soyeon
name: Kobetz, Erin N.
name: Hernandez, Monique N.
name: Lee, David J.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 3: Supplemental table 3. Adjusted multinomial logistic regression showing the odds of histologic types, age, and stage at diagnosis of thyroid cancer among white men in the FCDS 1981-2014; Thyroid tumor analytic dataset.
Model of the Belousov-Zhabotinsky reaction
Creators: name: Stys, Dalibor
name: Nahlik, Tomas
name: Zhyrova, Anna
name: Rychtarikova, Renata
name: Papacek, Stepan
name: Cisar, Petr
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cellular Automata and Lattice Gases (nlin.CG)
subject: FOS: Physical sciences

description: The article describes results of the modified model of the Belousov-Zhabotinsky reaction, which resembles rather well the limit set observed upon experimental performance of the reaction in the Petri dish. We discuss the concept of the ignition of circular waves and show that only the asymmetrical ignition leads to the formation of spiral structures. From the qualitative assumptions on the behavior of dynamic systems, we conclude that the Belousov-Zhabotinsky reaction likely forms a regular grid.
description: 17 pages, 12 figures
The effect of knowledge sharing behavior on organizational performance (Case Study: Iranian Space Agency)
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2017

description: Purpose: One of the main activities in the field of knowledge management, is knowledge sharing, because employees can play an important role in organizational competitive advantages. Effective knowledge sharing  can improve the quality of R&D activities. On the other hand it seems that, knowledge sharing behavior improvs organizational performances and competitive advantages for the organization. The aim of this study is to investigate the effects of knowledge sharing (with regards to attitude, intention and behavior) on organizational performances.\n\nMethodology: The research method is based on descriptive - survey and questionnaire methods that uses partial least squares by “SMARTPLS” software.\n\nResult and findings: Studying of 85 collected  questionnaire  showed that " attitude "  has positive and significant effect on " intention " and  " intention "has  a significant positive impact on "behavior". Also the knowledge sharing affects strongly on the performance of the Iranian Space Agency. Remarkably, the results indicate that all financial performance, processes performance and internal performance have positive impact on Iranian Space Agency performance.
title: Dangerous CT brain findings in head trauma warranting urgent intervention
Creators: name: Mohamed Abouelhoda, Pasant
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Trauma
subject: Neuroradiology brain
subject: CT
subject: MR
subject: VMAT and Tomotherapy
subject: Trauma

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To review the basic anatomy of CT brain. To recognize different patterns of head trauma on CT brain. To highlight the dangerous signs on CT brain requiringurgent intervention. To recognize when to ask for other radiological...
Multicolor Monitoring of the Proteasome’s Catalytic Signature
Creators: name: Lawrence, David S.
name: Schmidt, Marion
name: Wang, Qunzhao
name: Chowdhury, Ruma
name: Jernigan, Finith E.
name: Priestman, Melanie A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The proteasome, a validated anticancer target, participates in an array of biochemical activities, which range from the proteolysis of defective proteins to antigen presentation. We report the preparation of biochemically and photophysically distinct green, red, and far-red real-time sensors designed to simultaneously monitor the proteasome’s chymotrypsin-, trypsin-, and caspase-like activities, respectively. These sensors were employed to assess the effect of simultaneous multiple active site catalysis on the kinetic properties of the individual subunits. Furthermore, we have found that the catalytic signature of the proteasome varies depending on the source, cell type, and disease state. Trypsin-like activity is more pronounced in yeast than in mammals, whereas chymotrypsin-like activity is the only activity detectable in B-cells (unlike other mammalian cells). Furthermore, chymotrypsin-like activity is more prominent in transformed B cells relative to their counterparts from healthy donors.
(101232) Frank Wood Tricks
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
New economy: from crisis of dot-coms to virtual business
Creators: name: Kaluzhsky, Mikhail
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences

description: Article about objective regularity and mechanisms of formation of network economy in the conditions of crisis of «new economy». The network economy is considered as a basis of a following business cycle. The author analyzes features of institutional transformation of economic relations under the influence of development of cloudy technologies and the virtual organizations.
description: 13 pages, in Russian. ISSN 0204-3653
Neuropeptide Release Is Impaired in a Mouse Model of Fragile X Mental Retardation Syndrome
Creators: name: Wightman, R. Mark
name: Thornley, Keith T.
name: Annangudi, Suresh P.
name: Kile, Brian M.
name: Ren, Shifang
name: Hatcher, Nathan G.
name: Kim, Soong Ho
name: Sweedler, Jonathan V.
name: Weiler, Ivan Jeanne
name: Greenough, William T.
name: Luszpak, Agatha E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Fragile X syndrome (FXS), an inherited disorder characterized by mental retardation and autism-like behaviors, is caused by the failure to transcribe the gene for fragile X mental retardation protein (FMRP), a translational regulator and transporter of select mRNAs. FXS model mice (Fmr1 KO mice) exhibit impaired neuropeptide release. Release of biogenic amines does not differ between wild-type (WT) and Fmr1 KO mice. Rab3A, an mRNA cargo of FMRP involved in the recruitment of vesicles, is decreased by ∼50% in synaptoneurosomes of Fmr1 KO mice; however, the number of dense-core vesicles (DCVs) does not differ between WT and Fmr1 KO mice. Therefore, deficits associated with FXS may reflect this aberrant vesicle release, specifically involving docking and fusion of peptidergic DCVs, and may lead to defective maturation and maintenance of synaptic connections.
Assessing the effect of knowledge sharing on Employees' Psychological Empowerment by Clarifying Mediating Role of organizational memory and learning collaborative electronic in National Library and Archives of I.R of Iran
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2017

description: Nowadays knowledge has been enumerated as a valuable and important source in libraries. Knowledge sharing among employees is necessary for libraries’ survive and goal achievement. On the other hand, empowerment people with high moral are an important factor in the libraries’ survival and life. In other words, the importance of human resources is far from the new technology and material and financial resources. As a result, this study aimed at evaluating the effect of knowledge sharing on psychological empowerment with regard to organizational memory and learning electronic participation the role of the mediator. The research data were gathered from four areas named at organizing; communicating; education and logistic by questioner. Construct validity and cronbach's alpha coefficient were used for assessing the validity and reliability respectively. To hypotheses test, structural equation modeling and Lisrel software were used. The results show that knowledge sharing has a directly significant impact on psychological empowerment. While knowledge sharing has an indirect impact on psychological empowerment, this impact via organizational memory and electronic participation learning is far greater than its direct impact. The results also show that organizational memory has not any effect on the psychological empowerment.
Finite Volume for Three-Flavour Partially Quenched Chiral Perturbation Theory through NNLO in the Meson Sector
Creators: name: Bijnens, Johan
name: Rössler, Thomas
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present a calculation of the finite volume corrections to meson masses and decay constants in three flavour Partially Quenched Chiral Perturbation Theory (PQChPT) through two-loop order in the chiral expansion for the flavour-charged (or off-diagonal) pseudoscalar mesons. The analytical results are obtained for three sea quark flavours with one, two or three different masses. We reproduce the known infinite volume results and the finite volume results in the unquenched case. The calculation has been performed using the supersymmetric formulation of PQChPT as well as with a quark-flow technique. Partial analytical results can be found in the appendices. Some examples of cases relevant to lattice QCD are studied numerically. Numerical programs for all results are available as part of the CHIRON package.
description: 29 pages
Probing Presynaptic Regulation of Extracellular Dopamine with Iontophoresis
Creators: name: Belle, Anna M.
name: Wightman, R. Mark
name: Daniel, Kevin B.
name: Carelli, Regina M.
name: Herr, Natalie R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Iontophoresis allows for localized drug ejections directly into brain regions of interest driven by the application of current. Our lab has previously adapted a method to quantitatively monitor iontophoretic ejections. Here those principles have been applied in vivo to modulate electrically evoked release of dopamine in anesthetized rats. A neutral, electroactive marker molecule that is ejected purely by electroosmotic flow (EOF) was used to monitor indirectly the ejection of electroinactive dopaminergic drugs (raclopride, quinpirole, and nomifensine). Electrode placements were marked with an iontophoretically ejected dye, pontamine sky blue. We show that EOF marker molecules, acetaminophen (AP) and 2-(4-nitrophenoxy) ethanol (NPE), have no effect on electrically evoked dopamine release in the striatum or the sensitivity of electrode. Additionally, we establish that a short, 30 s ejection of raclopride, quinpirole, or nomifensine with iontophoresis is sufficient to affect autoreceptor regulation and the reuptake of dopamine. These effects vary in lifetime, indicating that this technique can be used to study receptor kinetics.
title: Sarcomas head and neck in pediatric patients: know them can save lives
Creators: name: Perez, Marcela
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Head and neck
subject: Paediatric
subject: Oncology
subject: CT
subject: MR
subject: Abscess delineation
subject: Biopsy
subject: Chemotherapy
subject: Pathology
subject: Cancer

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: CT and MRI are the imaging modalities of choice for the investigation of tumors in childrens, specially the sarcomas head and neck. The correct diagnosis include an understanding of the symptoms, anatomy, histology and treatment of sarcomas, in...
Using Fuzzy DEMATEL Technique to Ranking Knowledge Management Strategies
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2017

description: Knowledge is one of the most important resources of every company that must be effectively managed like any other resources. In addition to inter-organizational reasons, most of companies consider knowledge management and its effective usage as a leverage to be able to compete in their field. Although a lot of research has been conducted in this area, company's manager and decision makers fail in choosing the suitable knowledge management strategy which is the basis and initial step in their field of work. Therefore this research has been done with the goal of selecting the appropriate strategy for project oriented companies. Proposal of this research is to consider the main success factors of knowledge management, besides of its individual properties for each project, and also achievement of their reciprocal relationship through fuzzy DEMATEL method. For this purpose, according to previous studies, 6 main successful factors of knowledge management and 10 important properties of enterprise resource planning implementation project as secondary factors have been identified. Aforementioned project is related to one of the biggest distribution industry companies in Iran. Selected factors serve as assessment criterion for 3 Human-oriented strategy, system-oriented strategy, and dynamic strategy. Finally, by using fuzzy DEMATEL method, importance and efficacy of each strategy according to criteria has been identified.
title: Art and neuroradiology
Creators: name: Nieto, Karen
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Perception image
subject: Diagnostic procedure
subject: Computer Applications-General
subject: MR-Angiography
subject: MR
subject: CT
subject: Neuroradiology brain
subject: CNS
subject: Acute

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Art and science have always been related. From the Greek sculptures that represent the beautiful anatomy of the human body to the amazing illustrations of the brain made by Leonardo da Vinci there are many examples throughout the ages. Art and...
Designing a model of electronic human resource managementâs implementation at the Ministry of Communications and Information Technology
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2017

description: In the first phase of this study a model for electronic human resource management in government agencies based on new public services was explored by using software MAXQDA, then in the second phase, relationship between the elements of the theory were tested using software Smart PLS2. So the aim of this study is to design a model of electronic human resource management’s implementation at the Ministry of Communications and Information Technology. In this regard, according to Strauss and Corbin’s structured plan, five hypotheses were tested. Quantitative data analysis indicates that the pressures of the policies and global perspectives cause to move toward e-HRM. Among the contextual conditions macro structural mechanisms, considerations of actors, governance considerations have a significant impact on the strategy of new public services and therefore lead to the consequences of its implementation in public organizations. The findings suggest that e-HRM does not have a positive and meaningful impact on new public services, and in our country, although the recent political developments have somehow removed the gap between public policy makers, administrators, and the public, but there is still a long way to go.
(101233) George Snow Tricks
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Assessing Principal Component Regression Prediction of Neurochemicals Detected with Fast-Scan Cyclic Voltammetry
Creators: name: Wightman, R. Mark
name: Keithley, Richard B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Principal component regression is a multivariate data analysis approach routinely used to predict neurochemical concentrations from in vivo fast-scan cyclic voltammetry measurements. This mathematical procedure can rapidly be employed with present day computer programming languages. Here, we evaluate several methods that can be used to evaluate and improve multivariate concentration determination. The cyclic voltammetric representation of the calculated regression vector is shown to be a valuable tool in determining whether the calculated multivariate model is chemically appropriate. The use of Cook’s distance successfully identified outliers contained within in vivo fast-scan cyclic voltammetry training sets. This work also presents the first direct interpretation of a residual color plot and demonstrated the effect of peak shifts on predicted dopamine concentrations. Finally, separate analyses of smaller increments of a single continuous measurement could not be concatenated without substantial error in the predicted neurochemical concentrations due to electrode drift. Taken together, these tools allow for the construction of more robust multivariate calibration models and provide the first approach to assess the predictive ability of a procedure that is inherently impossible to validate because of the lack of in vivo standards.
title: Congenital cardiac anomalies with a nomal four chamber veiw
Creators: name: Sachdev, Lekha
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Congenital
subject: Screening
subject: Ultrasound
subject: Ultrasound-Colour Doppler
subject: Echocardiography
subject: Arteries / Aorta
subject: Foetal imaging
subject: Cardiac

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Cardiovascular anomlaies are very frequently encountered on an antenatal scan between the age of 18 to 22 weeks. The aim of the study is to diagnose a spectrum of fetal cardiac anomalies using cardiac scanning views apart from the routine four...
Chronically Implanted, Nafion-Coated Ag/AgCl Reference Electrodes for Neurochemical Applications
Creators: name: Takmakov, Pavel
name: Walsh, Paul L.
name: Crews, Fulton T.
name: Guillot, Thomas S.
name: Gras-Najjar, Julie
name: Wightman, R. Mark
name: Hashemi, Parastoo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Fast-scan cyclic voltammetry at carbon-fiber microelectrodes can be used to measure behaviorally correlated dopamine changes in the extracellular fluid of the brain of freely moving rats. These experiments employ a chronically implanted Ag/AgCl reference electrode. When dopamine measurements are taken 4 days after implantation, there is often a potential shift, typically greater than +0.2 V, in the anodic and cathodic peaks in the cyclic voltammogram for dopamine. In this work, we optimized a method to coat sintered Ag/AgCl reference electrodes with the perfluorinated polymer, Nafion, to prevent this shift. We find that we can stabilize reference electrodes for up to 28 days. Immunohistochemistry of the tissue around the implant site shows extensive glial encapsulation around both bare and Nafion-coated devices. However, the lesion around bare electrodes has a rough texture implying that these cells are strongly adsorbed onto the bare reference electrode, while the lesion around a Nafion-coated electrode shows that cells are more intact implying that they adsorb less strongly. Energy dispersive X-ray spectroscopy and scanning electron microscopy analysis of the surface of the electrodes confirms this by visualizing a heavy buildup of plaques, organic in nature, only on bare electrodes. Impedance spectroscopy indicates no difference between the impedance of bare and Nafion-coated Ag/AgCl electrodes, indicating that glial encapsulation does not lead to an increase in uncompensated resistance between the working and reference electrodes. The electrochemical shift therefore must be due to the unique chemical microenvironment around the reference electrode that alters the chloride equilibrium, a process that the Nafion coating prevents.
Development and Characterization of Novel Derivatives of the Antiepileptic Drug Lacosamide That Exhibit Far Greater Enhancement in Slow Inactivation of Voltage-Gated Sodium Channels
Creators: name: Khanna, Rajesh
name: Wilson, Sarah M.
name: Park, Ki Duk
name: Wang, Yuying
name: Liu, Rihe
name: Kohn, Harold
name: Stables, James P.
name: Salomé, Christophe
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The novel antiepileptic drug (R)-N-benzyl 2-acetamido-3-methoxypropionamide ((R)-lacosamide, Vimpat ((R)-1)) was recently approved in the United States and Europe for adjuvant treatment of partial-onset seizures in adults. (R)-1 preferentially enhances slow inactivation of voltage-gated Na+ currents, a pharmacological process relevant in the hyperexcitable neuron. We have advanced a strategy to identify lacosamide binding partners by attaching affinity bait (AB) and chemical reporter (CR) groups to (R)-1 to aid receptor detection and isolation. We showed that select lacosamide AB and AB&CR derivatives exhibited excellent activities similar to (R)-1 in the maximal electroshock seizure model in rodents. Here, we examined the effect of these lacosamide AB and AB&CR derivatives and compared them with (R)-1 on Na+ channel function in central nervous system (CNS) catecholaminergic (CAD) cells. Using whole-cell patch clamp electrophysiology, we demonstrated that the test compounds do not affect the Na+ channel fast inactivation process, that they were far better modulators of slow inactivation than (R)-1, and that modulation of the slow inactivation process was stereospecific. The lacosamide AB agents that contained either an electrophilic isothiocyanate ((R)-5) or a photolabile azide ((R)-8) unit upon AB activation gave modest levels of permanent Na+ channel slow inactivation, providing initial evidence that these compounds may have covalently reacted with their cognate receptor(s). Our findings support the further use of these agents to delineate the (R)-1-mediated Na+ channel slow inactivation process.
What are the aims of managers in developing digital libraries?
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2017

description: The aim of this study is to identify the goals of governmental organizations in developing digital libraries. The used methodology is Grounded Theory. This study used three step systematic method of the mentioned research method. Interview with 11 digital library managers help us to collect data. The collected data filtered by coding steps and demonstrated by Paradigm model. Results showed that settling users’ information needs, usage of digital library technology capability, presenting simple access to information resources and productivity promotion are the main purposes of developing digital libraries in governmental organizations. Also paradigm model showed that terms of intervention in developing digital libraries are research and education system, economic issues, and organizational limitations. Also underlying conditions are mechanism of organizations’ culture promotion. Outcomes are resolving user’s information needs, promoting user satisfaction, audience engagement, competition with search engines and big databases, information economy, cultural, societal and economic development, and organizational Excellence.
Additional file 1 of Attitudes toward preimplantation genetic testing and quality of life among individuals with hereditary diffuse gastric cancer syndrome
Creators: name: Shah, Ibrahim H.
name: Salo-Mullen, Erin E.
name: Amoroso, Kimberly A.
name: Kelsen, David
name: Stadler, Zsofia K.
name: Hamilton, Jada G.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Computational Biology

description: Additional file 1. Survey Items.
title: Spine Trauma and Major Complications
Creators: name: Tufik, Sergio Brasil
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Musculoskeletal spine
subject: Musculoskeletal system
subject: Neuroradiology spine
subject: CT
subject: MR
subject: Education
subject: Trauma

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Brief review of the mechanisms of spine trauma. To point the role of imaging methods on evaluation of spine trauma, discussing the image characteristics and the advantages and disadvantages of each imaging modality, besides outlining the main...
(101234) William Tricks
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A basis for designing digital library maturity model: Meta-synthesis method application
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2017

description: Digital Library (DL) development is faced with many challenges which cannot be overcome all at once. In such cases which are so complex, maturity models are utilized. In a maturity model, features of a phenomenon are classified into few levels so that improving or realizing the features of each level is the prerequisite of going to the next level. DL can also be approached by maturity model more efficiently and effectively. Since the maturity model for DL has not been designed yet, first, a literature review of the DL and maturity models using a qualitative approach and meta-synthesis method was done. According to the findings of the literature review, the maturity characteristics of DL are proposed to be a basis for designing DL maturity model. Since the concept of maturity and DL is extensive and has several dimensions, meta-synthesis has been found as a suitable method for comprehensive integration of the models offered in other areas with the existing literature in the field of DL based on their interpretation. To do so, 68 papers (38 in the field of DL and 30 in the field of maturity models in various fields) were selected from the available resources. By analyzing these papers, three categories, seven concepts, and 35 codes obtained as DL maturity features. Among these findings, the focuses of previous studies have been on the use of software/ hardware systems as supporter and enabler of DL and the DL content. The found features, in addition to be a basis for designing of digital library model, can be a tool in the hands of project managers of DL for assessing the status of their projects and planning to achieve higher levels of maturity.
Investigating the Application of Semantic Technology to Organize Information in Digital Library Software Systems
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2017

description: The present study was an attempt to investigate the use of semantic technologies to organize information in digital library software systems.\nThe present study was a practical one which employed a descriptive survey method. The study sample consisted of three digital library software systems entitled Pars Azarakhsh, Parvan Pajoh, and Payam Mashregh. Data were collected through a checklist including three sections: semantic technology architecture, tools and levels of implementation, and the types of information sources and their levels of use. The validity of the checklist was confirmed by experts. Cronbach’s alpha was also used to estimate the reliability of the checklist and the index turned out to be 0.94. Data were analyzed by the descriptive statistics such as frequency, percentage, and analysis of variance.\nThe results indicated that digital libraries with respect to the application of semantic technology were not in good condition; therefore, they need to take all the weaknesses identified in this study into consideration. Software for IT architecture requires layers of meaning beyond their original design. In addition, regarding the languages implemented, semantic technology had very poor performance and none of the tools had this new technology to develop and implement. The majority of the tools employed were also in the initial stage of recognition. In many cases, information sources were kept outside of the databases and they had only text files for full-text search. On the whole, the software systems studied here were at the same level although they sometimes surpassed each other.\nThe present study not only developed a checklist of the application of semantic technologies to organize information software digital library based on relevant literature and the experts, but also can make digital library software developers aware of their strengths and weaknesses, and the criteria and factors existing in this area in addition to the importance of each of them to help them in their own design and production in the future.
Quantum nonlocality via local contextuality with qubit-qubit entanglement
Creators: name: Saha, Debashis
name: Cabello, Adán
name: Choudhary, Sujit K.
name: Pawłowski, Marcin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum nonlocality can be revealed "via local contextuality" in qudit-qudit entangled systems with $d > 2$, that is, through the violation of inequalities containing Alice-Bob correlations that admit a local description, and Alice-Alice correlations (between the results of sequences of measurements on Alice's subsystem) that admit a local (but contextual) description. A fundamental question to understand the respective roles of entanglement and local contextuality is whether nonlocality via local contextuality exists when the parties have only qubit-qubit entanglement. Here we respond affirmatively to this question. This result further clarifies the connection between contextuality and nonlocality and opens the door for observing nonlocality via local contextuality in actual experiments.