Additional file 1 of A case for improved assessment of gut permeability: a meta-analysis quantifying the lactulose:mannitol ratio in coeliac and Crohn’s disease
Creators: name: Gan, Jonathan
name: Nazarian, Scarlet
name: Teare, Julian
name: Darzi, Ara
name: Ashrafian, Hutan
name: Thompson, Alex J.
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1: Appendix 1: Search Strategy for gut permeability and lactulose mannitol test in disease in Medline. Appendix 2: Search Strategy for gut permeability and lactulose mannitol test in disease in Embase. Appendix 3: Search Strategy for gut permeability and lactulose mannitol test in disease in Cochrane. Figure S1: PRISMA 2009 Flow diagram for coeliac disease. Figure S2: PRISMA 2009 Flow diagram for Crohn’s disease. Figure S3A: Standard Mean Difference (SMD) in LMR between treated coeliac disease and healthy controls. Figure S3B: Weighted Mean Difference (WMD) in LMR between treated coeliac disease and healthy controls. Figure S3C: Standard Mean Difference (SMD) in LMR between untreated coeliac disease and healthy controls. Figure S3D: Weighted Mean Difference (WMD) in LMR between untreated coeliac disease and healthy controls. Figure S3E: Standard Mean Difference (SMD) in LMR between untreated and treated coeliac disease. Figure S3F: Weighted Mean Difference (WMD) in LMR between untreated and treated coeliac disease. Figure S4A: Standard Mean Difference (SMD) in LMR between healthy controls and inactive Crohn's disease. Figure S4B: Weighted Mean Difference (WMD) in LMR between healthy controls and inactive Crohn's disease. Figure S4C: Standard Mean Difference (SMD) in LMR between active Crohn's disease and healthy controls. Figure S4D: Weighted Mean Difference (WMD) in LMR between active Crohn's disease and healthy controls. Figure S4E: Standard Mean Difference (SMD) in LMR between active and inactive Crohn's disease. Figure S4F: Weighted Mean Difference (WMD) in LMR between active and inactive Crohn's disease. Figure S5: Sensitivity and specificity of the L:M test in coeliac disease. Figure S6: Risk of bias for each risk of bias item in RCT studies. Figure S7: Risk of bias assessments presented per risk of bias domain in RCT studies. Figure S8: Risk of bias for each risk of bias item in non-randomised and cohort studies. Figure S9: Risk of bias assessments presented per risk of bias domain in non-randomised and cohort studies. Table S1: Summary of studies of gut permeability in Crohn’s disease. Table S2: Summary of studies of gut permeability in coeliac disease. Table S3: Sources of variability for the studies included in the meta-analysis. Table S4: Studies depicting sensitivity and specificity of LMR in screening for coeliac disease. Table B1: Newcastle Ottawa Score Assessing Risk of Bias for Case Control Studies. Table B2: Newcastle Ottawa Score Assessing Risk of Bias for Cross Sectional Studies. Table B3: Risk of Bias for Randomised Control Trials (RCT) using the Cochrane Risk of Bias Tool. Table B4: Risk of Bias in non-randomised trials and cohort studies using the ROBINS-I score.