title: Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð°Ð»ÑÑÐµÑÐ½Ð°ÑÐ¸Ð²Ð½Ð¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ Ð´Ð¾ÑÑÐ°Ð²ÐºÐ¸ ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ð° Ð Ð°Ð´Ð¸Ñ-223 Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ ÑÐ°ÑÑÐ¸Ñ ÐºÐ°ÑÐ±Ð¾Ð½Ð°ÑÐ° ÐºÐ°Ð»ÑÑÐ¸Ñ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Development of an alternative delivery system for the radionuclide Radium-223 based on calcium carbonate particles
Creators: name: ÐÑÐ¼ÐµÑÐ¾Ð²Ð°, ÐÐ°ÑÑÑ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2023
Subjects: ÑÐ°Ð´Ð¸Ð¾ÑÐµÑÐ°Ð¿Ð¸Ñ
Ð¼Ð¸ÐºÑÐ¾ÑÐ°ÑÑÐ¸ÑÑ
ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ñ
Ð°Ð»ÑÑÐ°-Ð¸Ð·Ð»ÑÑÐµÐ½Ð¸Ðµ
ÐºÐ°ÑÐ±Ð¾Ð½Ð°Ñ ÐºÐ°Ð»ÑÑÐ¸Ñ
ÑÐ°Ð´Ð¸Ð¹-223
radiotherapy
microparticles
radio nuclides
alpha radiation
calcium carbonate
radium-223

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐµ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ð¸ ÑÐ¸Ð½ÑÐµÐ·Ð° Ð¼Ð¸ÐºÑÐ¾ÑÐ°ÑÑÐ¸Ñ ÐºÐ°ÑÐ±Ð¾Ð½Ð°ÑÐ° ÐºÐ°Ð»ÑÑÐ¸Ñ Ñ Ð¿Ð¾ÑÐ»ÐµÐ´ÑÑÑÐ¸Ð¼ ÑÑÑÐµÐºÑÐ¸Ð²Ð½ÑÐ¼ Ð²ÐºÐ»ÑÑÐµÐ½Ð¸ÐµÐ¼ Ð² ÑÑÑÑÐºÑÑÑÑ ÑÐ°ÑÑÐ¸Ñ ÑÐµÑÐ°Ð¿ÐµÐ²ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¸Ð·Ð¾ÑÐ¾Ð¿Ð° ÑÐ°Ð´Ð¸Ñ-223 Ð¸ ÐµÐ³Ð¾ ÑÐ´ÐµÑÐ¶Ð°Ð½Ð¸ÐµÐ¼, Ð° ÑÐ°ÐºÐ¶Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð½Ð¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ Ð´Ð¾ÑÑÐ°Ð²ÐºÐ¸ Ð² ÑÐµÑÐ°Ð¿Ð¸Ð¸ Ð·Ð»Ð¾ÐºÐ°ÑÐµÑÑÐ²ÐµÐ½Ð½ÑÑ Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ð¹ in vitro Ð¸ in vivo. Ð ÑÐ¾Ð´Ðµ ÑÐ°Ð±Ð¾ÑÑ Ð±ÑÐ»Ð¸ Ð¿Ð¾ÑÑÐ°Ð²Ð»ÐµÐ½Ñ Ð¸ ÑÐµÑÐµÐ½Ñ ÑÐ»ÐµÐ´ÑÑÑÐ¸Ðµ Ð·Ð°Ð´Ð°ÑÐ¸: 1) Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð° ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ñ ÑÐ¸Ð½ÑÐµÐ·Ð° ÑÑÐµÑÐ¸ÑÐµÑÐºÐ¸Ñ ÐÐ§ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ ÐºÐ°ÑÐ±Ð¾Ð½Ð°ÑÐ° ÐºÐ°Ð»ÑÑÐ¸Ñ; 2) Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½ Ð¿ÑÐ¾ÑÐ¾ÐºÐ¾Ð» ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð²ÐºÐ»ÑÑÐµÐ½Ð¸Ñ Ð¸Ð·Ð¾ÑÐ¾Ð¿Ð° ÑÐ°Ð´Ð¸Ñ-223 Ð² ÑÑÑÑÐºÑÑÑÑ ÐÐ§ ÐºÐ°ÑÐ±Ð¾Ð½Ð°ÑÐ° ÐºÐ°Ð»ÑÑÐ¸Ñ; 3) ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð° Ð¿Ð¾Ð»Ð½Ð°Ñ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸Ð·Ð°ÑÐ¸Ñ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ Ð½Ð¾ÑÐ¸ÑÐµÐ»ÐµÐ¹ Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ ÑÐ¸Ð·Ð¸ÐºÐ¾-ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ¸Ñ Ð¼ÐµÑÐ¾Ð´Ð¾Ð²; 4) ÐÐ°Ð½Ð° ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²ÐµÐ½Ð½Ð°Ñ Ð¾ÑÐµÐ½ÐºÐ° ÑÐ°Ð´Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ Ð½Ð¾ÑÐ¸ÑÐµÐ»ÐµÐ¹ ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ð¾Ð² Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð´Ð¾Ð·Ð¸Ð¼ÐµÑÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¸ Ð°Ð½Ð°Ð»Ð¸ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¾Ð±Ð¾ÑÑÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ; 5) ÐÐ·ÑÑÐµÐ½Ð¾ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ Ð½Ð¾ÑÐ¸ÑÐµÐ»ÐµÐ¹ Ð½Ð° Ð¾Ð¿ÑÑÐ¾Ð»ÐµÐ²ÑÑ ÑÐºÐ°Ð½Ñ Ð² in vitro Ð¸ in vivo Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸ÑÑ. Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð±ÑÐ»Ð° ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð° ÑÐ¸ÑÑÐµÐ¼Ð° Ð´Ð¾ÑÑÐ°Ð²ÐºÐ¸ ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ð° ÑÐ°Ð´Ð¸Ñ-223 Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ ÑÑÐµÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¼Ð¸ÐºÑÐ¾ÑÐ°ÑÑÐ¸Ñ ÐºÐ°ÑÐ±Ð¾Ð½Ð°ÑÐ° ÐºÐ°Ð»ÑÑÐ¸Ñ, ÐºÐ¾ÑÐ¾ÑÐ°Ñ, Ð¿Ð¾ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐ°Ð¼ in vitro Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¹, ÑÐ²Ð»ÑÐµÑÑÑ Ð±Ð¸Ð¾ÑÐ¾Ð²Ð¼ÐµÑÑÐ¸Ð¼Ð¾Ð¹ Ð¸ Ð¾Ð±Ð»Ð°Ð´Ð°ÐµÑ Ð½Ð¸Ð·ÐºÐ¸Ð¼ Ð¿ÑÐ¾ÑÐ¸Ð»ÐµÐ¼ ÑÐ¾ÐºÑÐ¸ÑÐ½Ð¾ÑÑÐ¸. Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð½Ð°Ñ Ð¼ÐµÑÐ¾Ð´Ð¸ÐºÐ° ÑÐ°Ð´Ð¸Ð¾Ð¼ÐµÑÐµÐ½Ð¸Ñ Ð¼Ð¸ÐºÑÐ¾ÑÐ°ÑÑÐ¸Ñ ÐºÐ°ÑÐ±Ð¾Ð½Ð°ÑÐ° ÐºÐ°Ð»ÑÑÐ¸Ñ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð»Ð° Ð²ÑÑÐ¾ÐºÑÑ ÑÑÐµÐ¿ÐµÐ½Ñ ÑÐ´ÐµÑÐ¶Ð°Ð½Ð¸Ñ Ð¸Ð·Ð¾ÑÐ¾Ð¿Ð° Ð¿ÑÐ¸ ÐºÐ¾Ð½ÑÐ°ÐºÑÐµ Ñ ÑÐ¸Ð·Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ð¼Ð¸ Ð¶Ð¸Ð´ÐºÐ¾ÑÑÑÐ¼Ð¸. ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ in vivo Ð´Ð¾ÐºÐ°Ð·Ð°Ð»Ð¸ ÑÐµÑÐ°Ð¿ÐµÐ²ÑÐ¸ÑÐµÑÐºÑÑ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ ÑÐ¸ÑÑÐµÐ¼Ñ Ð´Ð¾ÑÑÐ°Ð²ÐºÐ¸ Ð² ÐºÐ°ÑÐµÑÑÐ²Ðµ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ° Ð´Ð»Ñ Ð»ÐµÑÐµÐ½Ð¸Ñ Ð·Ð»Ð¾ÐºÐ°ÑÐµÑÑÐ²ÐµÐ½Ð½ÑÑ Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ð¹.
description: This work is devoted to the development of a technology for the synthesis of calcium carbonate microparticles with subsequent effective inclusion of the therapeutic isotope of radium-223 into the particle structure and its retention, as well as to the study of the effectiveness of the developed delivery system in the treatment of malignant tumors in vitro and in vivo. In the course of the work, the following tasks were set and solved: 1) A technology for the synthesis of spherical MPs based on calcium carbonate has been developed; 2) A protocol for the efficient incorporation of the radium-223 isotope into the structure of calcium carbonate MPs has been developed; 3) A complete characterization of the obtained carriers was carried out using physicochemical methods; 4) A quantitative assessment of the radiological activity of the obtained carriers of radionuclides using dosimetric and analytical equipment was given; 5) The effect of carriers on tumor tissue in vitro and in vivo was studied. As a result, a radium-223 radionuclide delivery system based on spherical calcium carbonate microparticles was developed, which, according to the results of in vitro studies, is biocompatible and has a low toxicity profile. The developed technique for radiolabeling calcium carbonate microparticles showed a high degree of isotope retention upon contact with physiological fluids. In vivo studies have proven the therapeutic efficacy of the delivery system as a drug for the treatment of malignancies.