cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A comparative analysis of daunorubicin and its metabolite daunorubicinol interaction with apoptotic and drug resistance proteins using in silico approach
Creators: name: Kumar, Ajit
name: Satija, Neeraj Kumar
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Daunorubicin (DNR) is a chemotherapeutic drug associated with multiple side effects, including drug resistance. As the molecular mechanism related to these side effects remain unclear and mostly hypothesized, this study addresses and compares the role of DNR and its metabolite Daunorubicinol (DAUNol) to induce apoptosis and drug resistance using molecular docking, Molecular Dynamics (MD) simulation, MM-PBSA and chemical pathway analysis. The results showed that DNR's interaction was stronger with Bax protein, Mcl-1:mNoxaB and Mcl-1:Bim protein complexes than DAUNol. On the other hand, contrasting results were obtained for drug resistance proteins where stronger interaction was obtained with DAUNol compared to DNR. Further, MD simulation performed for 100 ns provided the details of protein-ligand interaction. Most notable was the interaction of Bax protein with DNR, resulting in conformational changes at α-helices 5, 6 and 9, leading to Bax activation. Finally, the chemical signalling pathway analysis also revealed the regulation of different signalling pathways by DNR and DAUNol. It was observed that DNR majorly impacted the signalling associated with apoptosis while DAUNol mainly targeted pathways related to multidrug resistance and cardiotoxicity. Overall, the results highlight that DNR biotransformation reduces its capability to induce apoptosis while enhancing its ability to induce drug resistance and off-target toxicity. Communicated by Ramaswamy H. Sarma
title: Wernervs Martyr; 1630
title: Das ist, Ein Lust- vnnd Trawriges Schawspil, welches die grössere Academische Congregation vnser lieben Frawen, zu Ingolstatt, Dem Hoch vnd Wolgebornen Grauen vnnd Herrn Herrn Werner Tserclaes, Grauen von Tilli, ... vnd jetziger zeit, eben derselbigen Academischen Congregation Hochansehlichen Praefecto, zu Ehren angestellet. Vnnd halten wirdt zum theyl den 15. zum theyl den 16. Tag Octobris. Anno 1630
titleType: Subtitle
Creators: name: (:Unav)
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2012

description: Perioche
Additional file 4 of Surface and deep learning: a blended learning approach in preclinical years of medical school
Creators: name: Khong, Mei Li
name: Tanner, Julian Alexander
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Astronomical and Space Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Supplementary Material 4. Additional file 4: Participants’ characteristics according to SAL theory.
title: Thomas Morvs, Das ist: Tragoedia Von Thoma Moro, Dem, vor Gott und der Welt berümbten, Engeländischen ReichsCantzler; 1631
title: Wellicher vor 96 Jahren, von dem Gottlosen Wieterich Henrico, der Engelländischen König, wegen Verfechtung wahren Glaubens, vnd H. Römischen Stuelß, Tyrannischer weiß hingerichtet worden. Gehalten in dem Churfürstlichen Academischen Gymnasio der Societet Iesv zu Ingolstatt. Den 15. Octobris, Anno M. DC. XXXI
titleType: Subtitle
Creators: name: (:Unav)
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2012

description: Perioche. - Zusatz zum Sacht.: Druckfehler (Zeilenumbruch)
Patent, Warumb Ihr F. D. zu Lothringen den 25. Febr. dieses Jahrs, von der Spanischen Regierung in Flandern in Arrest genommen, vnd nach Antorff vff das Castell geführt worden; 1654
Creators: name: (:Unav)
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2012

description: Nicht identisch mit VD17 12:187899M
Physical foundations of biological complexity
Creators: name: Wolf, Yuri I.
name: Katsnelson, Mikhail I.
name: Koonin, Eugene V.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Populations and Evolution (q-bio.PE)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Biological systems reach hierarchical complexity that has no counterpart outside the realm of biology. Undoubtedly, biological entities obey the fundamental physical laws. Can today's physics provide an explanatory framework for understanding the evolution of biological complexity? We argue here that the physical foundation for understanding the origin and evolution of complexity can be envisaged at the interface between the theory of frustrated states resulting in pattern formation in glass-like media and the theory of self-organized criticality (SOC). On the one hand, SOC has been shown to emerge in spin glass systems of high dimensionality. On the other hand, SOC is often viewed as the most appropriate physical description of evolutionary transitions in biology. We unify these two faces of SOC by showing that emergence of complex features in biological evolution typically if not always is triggered by frustration that is caused by competing interactions at different organizational levels. Competing interactions and frustrated states permeate biology at all organizational levels and are tightly linked to the ubiquitous competition for limiting resources. This perspective extends from the comparatively simple phenomena occurring in glasses to large-scale events of biological evolution, such as major evolutionary transitions. We therefore submit that frustration caused by competing interactions in multidimensional systems is the general driving force behind the emergence of complexity, within and beyond the domain of biology.
description: 27 pages, 2 figures
Additional file 1 of Key stakeholders’ perspectives of illicit drug use and associated harms in the Northern Territory of Australia
Creators: name: Brickley, Bryce
name: Moore, Samuel
name: Tari-Keresztes, Noemi
name: Brand, Anthea
name: Bower, Madeleine
name: Bonson, Jason G.
name: McEntee, Alice
name: Bartram, Ashlea J.
name: Bovopoulos, Nataly
name: McPhie, Skye
name: Martin, Craig
name: Wright, Cassandra
name: Bowden, Jacqueline
name: Smith, James A.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1
Practice Abstracts BRANCHES PROJECT H2020 - PA1
Creators: name: Matteo Monni (ITABIA), Raffele Spinelli (CNR-IBE)
Publisher: name: Zenodo
Year: 2022
Subjects: Bioenergy, rural areas, biomass, prunings, olive tree, circular bioeconomy, management, technological innovations, environmental benefits

description: BRANCHES will produce and share more than 50 case studies, considered Best Practices. The selected case studies will be summarized in Practice Abstracts (PAs), documents tailored for practitioners, shared through the project media and collected on this webpage. The numbering of the PAs only refers to chronological order of uploading.Enjoy your reading!
Sejong Open Cluster Survey (SOS). II. IC 1848 Cluster in the H II Region W5 West
Creators: name: Lim, Beomdu
name: Sung, Hwankyung
name: Kim, Jinyoung S.
name: Bessell, Michael S.
name: Karimov, Rivkat
Publisher: name: arXiv
Year: 2013
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: IC 1848 is one of the young open clusters in the giant star forming Cas OB6 association. Several interesting aspects relating to star formation processes in giant star forming regions attracted us to study the initial mass function (IMF), star formation mode, and properties of pre-main sequence stars (PMS). A UBVI and H alpha photometric study of the young open cluster IC 1848 was conducted as part of the "Sejong Open cluster Survey" (SOS). We have selected 105 early-type members from photometric diagrams. Their mean reddening is = 0.660 +/- 0.054 mag. Using the published photometric data with near- and mid-infrared archival data we confirmed the normal reddening law (R_V = 3.1) toward the cluster (IC 1848). A careful zero-age main sequence fitting gives a distance modulus of V_0 - M_V = 11.7 +/- 0.2 mag, equivalent to 2.2 +/- 0.2 kpc. H alpha photometry and the list of young stellar objects identified by Koenig et al. permitted us to select a large number of PMS stars comprising 196 H alpha emission stars, 35 H alpha emission candidates, 5 Class I, 368 Class II, and 24 transition disk candidates. From the Hertzsprung-Russell diagram using stellar evolution models, we estimate an age of 5 Myr from several evolved stars and 3 Myr from the PMS stars. The IMF was derived from stars with mass larger than 3 M_sun, and the slope is slightly steeper (Gamma = -1.6 +/- 0.2) than the Salpeter/Kroupa IMF. Finally, we estimated the mass accretion rate of PMS stars with a UV excess. The mean mass accretion rate is about 1.4 x 10^-8 M_sun yr^-1 in the mass range of 0.5 M_sun to 2 M_sun, whereas intermediate-mass stars (>= 2.5 M_sun) exhibit a much higher accretion rate of dM/dt > 10^-6 M_sun yr^-1.
description: 17 pages, 13 figures, 3 tables, accepted for publication in MNRAS
Quantum Algorithm Implementations for Beginners
Creators: name: J., Abhijith
name: Adedoyin, Adetokunbo
name: Ambrosiano, John
name: Anisimov, Petr
name: Casper, William
name: Chennupati, Gopinath
name: Coffrin, Carleton
name: Djidjev, Hristo
name: Gunter, David
name: Karra, Satish
name: Lemons, Nathan
name: Lin, Shizeng
name: Malyzhenkov, Alexander
name: Mascarenas, David
name: Mniszewski, Susan
name: Nadiga, Balu
name: O'Malley, Daniel
name: Oyen, Diane
name: Pakin, Scott
name: Prasad, Lakshman
name: Roberts, Randy
name: Romero, Phillip
name: Santhi, Nandakishore
name: Sinitsyn, Nikolai
name: Swart, Pieter J.
name: Wendelberger, James G.
name: Yoon, Boram
name: Zamora, Richard
name: Zhu, Wei
name: Eidenbenz, Stephan
name: Bärtschi, Andreas
name: Coles, Patrick J.
name: Vuffray, Marc
name: Lokhov, Andrey Y.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Emerging Technologies (cs.ET)
subject: Quantum Physics (quant-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: As quantum computers become available to the general public, the need has arisen to train a cohort of quantum programmers, many of whom have been developing classical computer programs for most of their careers. While currently available quantum computers have less than 100 qubits, quantum computing hardware is widely expected to grow in terms of qubit count, quality, and connectivity. This review aims to explain the principles of quantum programming, which are quite different from classical programming, with straightforward algebra that makes understanding of the underlying fascinating quantum mechanical principles optional. We give an introduction to quantum computing algorithms and their implementation on real quantum hardware. We survey 20 different quantum algorithms, attempting to describe each in a succinct and self-contained fashion. We show how these algorithms can be implemented on IBM's quantum computer, and in each case, we discuss the results of the implementation with respect to differences between the simulator and the actual hardware runs. This article introduces computer scientists, physicists, and engineers to quantum algorithms and provides a blueprint for their implementations.
description: ACM Transactions on Quantum Computing
Additional file 1 of Comparative study of the growth, stress status and reproductive capabilities of four wild-type zebrafish (Danio rerio) lines
Creators: name: Chevalier, Céline
name: Denis, Clémence
name: Nedjar, Sid-Ahmed
name: Ledoré, Yannick
name: Silvestre, Frédéric
name: Schaerlinger, Bérénice
name: Milla, Sylvain
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1. Traits measured during growth control from 10 dpf to 150 dpf.Total length;Snout-Operculum distance;Height at nape;Snout-Vent distance;Eye diameter. All the traits are in mm. Data are presented as mean ± standard deviation. Significant differences are represented by: p < 0.05; p < 0.01; p < 0.001
Projective representations and spin characters of complex reflection groups $G(m, p, n)$ and $G(m, p, \infty)$, III
Creators: name: Hirai, Takeshi
name: Hora, Akihito
Publisher: name: arXiv
Year: 2018
Subjects: subject: Representation Theory (math.RT)
subject: FOS: Mathematics
subject: 20C25, 20F55

description: This paper is a continuation of two previous papers in MSJ Memoirs, Vol.\,29 (Math. Soc. Japan, 2013) with the same title and numbered as I and II. Based on the hereditary property given there, from mother groups $G(m,1,n)$, the generalized symmetric groups, to child groups $G(m,p,n)$, the complex reflection groups, we study in detail classification and construction of irreducible projective representations (= spin representations) and their characters of $G(m,1,n)$ for $n$ finite. Then, taking limits as $n$ tends to infinity, we obtain spin characters of the inductive limit groups $G(m,1,\infty)$. By the heredity studied further, this gives the main kernel of the results for $G(m,p,\infty)$ with $p|m, p>1$.
description: 88 pages, typos corrected, references corrected
Stephen Hawking (1942-2018), Towards a Complete Understanding of the Universe
Creators: name: Hartle, James
Publisher: name: arXiv
Year: 2018
Subjects: subject: History and Philosophy of Physics (physics.hist-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Two of the major achievements of Stephen Hawking are described in elementary terms. They are his work on the beginning of the universe and his work on the end of black holes. These are perhaps the scientific achievements for which he is best known. Some of the qualities that enabled his great achievements are also described. The article is a slightly edited version of one solicited by the Proceedings of the (US) National Academy of Sciences for their Retrospectives section and will appear there.
description: 4 pages
Individuality and slow dynamics in bacterial growth homeostasis
Creators: name: Susman, Lee
name: Kohram, Maryam
name: Vashistha, Harsh
name: Nechleba, Jeffrey T.
name: Salman, Hanna
name: Brenner, Naama
Publisher: name: arXiv
Year: 2018
Subjects: subject: Cell Behavior (q-bio.CB)
subject: FOS: Biological sciences

description: Microbial growth and division are fundamental processes relevant to many areas of life science. Of particular interest are homeostasis mechanisms, which buffer growth and division from accumulating fluctuations over multiple cycles. These mechanisms operate within single cells, possibly extending over several division cycles. However, all experimental studies to date have relied on measurements pooled from many distinct cells. Here, we disentangle long-term measured traces of individual cells from one another, revealing subtle differences between temporal and pooled statistics. By analyzing correlations along up to hundreds of generations, we find that the parameter describing effective cell-size homeostasis strength varies significantly among cells. At the same time, we find an invariant cell size which acts as an attractor to all individual traces, albeit with different effective attractive forces. Despite the common attractor, each cell maintains a distinct average size over its finite lifetime with suppressed temporal fluctuations around it, and equilibration to the global average size is surprisingly slow (> 150 cell cycles). To demonstrate a possible source of variable homeostasis strength, we construct a mathematical model relying on intracellular interactions, which integrates measured properties of cell size with those of highly expressed proteins. Effective homeostasis strength is then influenced by interactions and by noise levels, and generally varies among cells. A predictable and measurable consequence of variable homeostasis strength appears as distinct oscillatory patterns in cell size and protein content over many generations. We discuss the implications of our results to understanding mechanisms controlling division in single cells and their characteristic timescales
description: In press with PNAS. 50 pages, including supplementary information
Sylvisorex morio
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Insectivora
Soricidae
Sylvisorex
Sylvisorex morio

description: Sylvisorex morio (Gray, 1862). Proc. Zool. Soc. Lond., 1862:180. TYPE LOCALITY: Cameroun, Mt. Cameroun. DISTRIBUTION: Cameroun; Bioko, perhaps Nigeria. COMMENT: Includes isabellae; see Heim de Balsac and Meester, 1977, Part 1:8. ISIS NUMBER: 5301403007022005001.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Insectivora, pp. 58-106 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 101, DOI: 10.5281/zenodo.7353001
description: {"references": ["Heim de Balsac, H., and J. Meester. 1977. Order Insectivora. Part 1. Pp. 1 - 29, in The mammals of Africa: An identification manual (J. Meester and H. W. Setzer, eds.). [issued 22 Aug 1977]. Smithsonian Institution Press, Washington, D. C., not continuously paginated."]}
Optimized simulated annealing for Ising spin glasses
Creators: name: Isakov, S. V.
name: Zintchenko, I. N.
name: Rønnow, T. F.
name: Troyer, M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: We present several efficient implementations of the simulated annealing algorithm for Ising spin glasses on sparse graphs. In particular, we provide a generic code for any choice of couplings, an optimized code for bipartite graphs, and highly optimized implementations using multi-spin coding for graphs with small maximum degree and discrete couplings with a finite range. The latter codes achieve up to 50 spin flips per nanosecond on modern Intel CPUs. We also compare the performance of the codes to that of the special purpose D-Wave devices built for solving such Ising spin glass problems.
description: 11 pages, includes C++11 codes. Minor updates
Practice Abstracts BRANCHES PROJECT H2020 - PA2
Creators: name: Raffaele Spinelli (CNR- IBE), Team ITABIA
Publisher: name: Zenodo
Year: 2022
Subjects: Microchips Local economy Agroforestry Business

description: Microchip, locally-made replacement for industrial chips
description: BRANCHES will produce and share more than 50 case studies, considered Best Practices. The selected case studies will be summarized in Practice Abstracts (PAs), documents tailored for practitioners, shared through the project media and collected on this webpage. The numbering of the PAs only refers to chronological order of uploading. Enjoy your reading!
Imaging the Renner-Teller effect using laser-induced electron diffraction
Creators: name: Amini, Kasra
name: Sclafani, Michele
name: Steinle, Tobias
name: Le, Anh-Thu
name: Sanchez, Aurelien
name: Müller, Carolin
name: Steinmetzer, Johannes
name: Yue, Lun
name: Saavedra, José Ramón Martínez
name: Hemmer, Michäel
name: Lewenstein, Maciej
name: Moshammer, Robert
name: Pfeifer, Thomas
name: Pullen, Michael G.
name: Ullrich, Joachim
name: Wolter, Benjamin
name: Moszynski, Robert
name: de Abajo, F. Javier García
name: Lin, C. D.
name: Gräfe, Stefanie
name: Biegert, Jens
Publisher: name: arXiv
Year: 2018
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Structural information on electronically excited neutral molecules can be indirectly retrieved, largely through pump-probe and rotational spectroscopy measurements with the aid of calculations. Here, we demonstrate the direct structural retrieval of neutral carbonyl disulfide (CS$_2$) in the B$^1$B$_2$ excited electronic state using laser-induced electron diffraction (LIED). We unambiguously identify the ultrafast symmetric stretching and bending of the field-dressed neutral CS$_2$ molecule with combined picometer and attosecond resolution using intrapulse pump-probe excitation and measurement. We invoke the Renner-Teller effect to populate the B$^1$B$_2$ excited state in neutral CS$_2$, leading to bending and stretching of the molecule. Our results demonstrate the sensitivity of LIED in retrieving the geometric structure of CS$_2$, which is known to appear as a two-center scatterer.
Sylvisorex ollula Thomas 1913
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Insectivora
Soricidae
Sylvisorex
Sylvisorex ollula

description: Sylvisorex ollula Thomas, 1913. Ann. Mag. Nat. Hist., ser. 8, 11: 321. TYPE LOCALITY: Cameroun, Bitye, Ja River, 2000 ft. (610 m). DISTRIBUTION: S. Cameroun; W. Zaire; Gabon. COMMENT: Possibly only subspecifically distinct from suncoides; see Heim de Balsac and Meester, 1977, Part 1:8. ISIS NUMBER: 5301403007020011001 as Suncus ollula.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Insectivora, pp. 58-106 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on pages 101-102, DOI: 10.5281/zenodo.7353001
description: {"references": ["Heim de Balsac, H., and J. Meester. 1977. Order Insectivora. Part 1. Pp. 1 - 29, in The mammals of Africa: An identification manual (J. Meester and H. W. Setzer, eds.). [issued 22 Aug 1977]. Smithsonian Institution Press, Washington, D. C., not continuously paginated."]}
Identification of novel natural product inhibitors of BRD4 using high throughput virtual screening and MD simulation
Creators: name: Barman, Soumen
name: Sahoo, Snehasudha Subhadarsini
name: Padhan, Jyotirmayee
name: Sudhamalla, Babu
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Hematology

description: Bromodomains are evolutionarily conserved structural motifs that recognize acetylated lysine residues on histone tails. They play a crucial role in shaping chromatin architecture and regulating gene expression in various biological processes. Mutations in bromodomains containing proteins lead to multiple human diseases, which makes them attractive target for therapeutic intervention. Extensive studies have been done on BRD4 as a target for several cancers, such as Acute Myeloid Leukemia (AML) and Burkitt Lymphoma. Several potential inhibitors have been identified against the BRD4 bromodomain. However, most of these inhibitors have drawbacks such as non-specificity and toxicity, decreasing their appeal and necessitating the search for novel non-toxic inhibitors. This study aims to address this need by virtually screening natural compounds from the NPASS database against the Kac binding site of BRD4-BD1 using high throughput molecular docking followed by similarity clustering, pharmacokinetic screening, MD simulation and MM-PBSA binding free energy calculations. Using this approach, we identified five natural product inhibitors having a similar or better binding affinity to the BRD4 bromodomain compared to JQ1 (previously reported inhibitor of BRD4). Further systematic analysis of these inhibitors resulted in the top three hits: NPC268484 (Palodesangren-B), NPC295021 (Candidine) and NPC313112 (Buxifoliadine-D). Collectively, our in silico results identified some promising natural products that have the potential to act as potent BRD4-BD1 inhibitors and can be considered for further validation through future in vitro and in vivo studies. Communicated by Ramaswamy H. Sarma
A Monte Carlo density functional theory for the competition between inter and intramolecular association in inhomogeneous fluids
Creators: name: Marshall, B. D.
name: Garcia-Cuellar, A. J.
name: Chapman, W. G.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: A monte carlo density functional theory is developed for chain molecules which both intra and intermolecularly associate. The approach can be applied over a range of chain lengths. The theory is validated for the case of an associating 4-mer fluid in a planar hard slit pore. Once validated the new theory is used to study the effect of chain length and temperature on the competition between intra and intermolecular association near a hard wall. We show that this competition enhances intramolecular association near wall contact and inverts the chain length dependence of the fraction bonded intermolecularly in the inhomogeneous region.
Multiple-object tracking in cluttered and crowded public spaces
Creators: name: Martin, Rhys
name: Arandjelović, Ognjen
Publisher: name: arXiv
Year: 2013
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: This paper addresses the problem of tracking moving objects of variable appearance in challenging scenes rich with features and texture. Reliable tracking is of pivotal importance in surveillance applications. It is made particularly difficult by the nature of objects encountered in such scenes: these too change in appearance and scale, and are often articulated (e.g. humans). We propose a method which uses fast motion detection and segmentation as a constraint for both building appearance models and their robust propagation (matching) in time. The appearance model is based on sets of local appearances automatically clustered using spatio-kinetic similarity, and is updated with each new appearance seen. This integration of all seen appearances of a tracked object makes it extremely resilient to errors caused by occlusion and the lack of permanence of due to low data quality, appearance change or background clutter. These theoretical strengths of our algorithm are empirically demonstrated on two hour long video footage of a busy city marketplace.
Sylvisorex suncoides Osgood 1936
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Insectivora
Soricidae
Sylvisorex
Sylvisorex suncoides

description: Sylvisorex suncoides Osgood, 1936. Field Mus. Nat. Hist. Publ. Ser. Zool., 20:217. TYPE LOCALITY: Zaire, W. slope Mt. Ruwenzori, Kalongi. DISTRIBUTION: E. Zaire; Uganda; perhaps Rwanda. COMMENT: Probably a subspecies of ollula; see Heim de Balsac and Meester, 1977, Part 1:8. ISIS NUMBER: 5301403007022008001.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Insectivora, pp. 58-106 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 102, DOI: 10.5281/zenodo.7353001
description: {"references": ["Heim de Balsac, H., and J. Meester. 1977. Order Insectivora. Part 1. Pp. 1 - 29, in The mammals of Africa: An identification manual (J. Meester and H. W. Setzer, eds.). [issued 22 Aug 1977]. Smithsonian Institution Press, Washington, D. C., not continuously paginated."]}
Broadcast Classical-Quantum Capacity Region of Two-Phase Bidirectional Relaying Channel
Creators: name: Boche, Holger
name: Cai, Minglai
name: Deppe, Christian
Publisher: name: arXiv
Year: 2014
Subjects: subject: Information Theory (cs.IT)
subject: Quantum Algebra (math.QA)
subject: Quantum Physics (quant-ph)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We study a three-node quantum network which enables bidirectional communication between two nodes with a half-duplex relay node. A decode-and-forward protocol is used to perform the communication in two phases. In the first phase, the messages of two nodes are transmitted to the relay node. In the second phase, the relay node broadcasts a re-encoded composition to the two nodes. We determine the capacity region of the broadcast phase.
Acts of Translation: Organized Networks as Algorithmic Technologies of the Common
Creators: name: Rossiter, Ned
name: Zehle, Soenke
Publisher: name: Zenodo
Year: 2012

description: Defined by the informatization of life and labor, the networked condition is characterized by the comprehensive connection of users to circuits of capital via predominantly corporate communication and information infrastructures. The economic value of these engines of entry into a world of communicative commerce is largely determined by the very acts of communication they elicit, structure, and sustain. And as the proliferation of proprietary mobile devices separates a new generation of users from previous, more localized generations of personal computing, the corresponding establishment of cloud computing as the primary infrastructural paradigm of storage and service delivery aimed at efficient data-mining establishes a new technocentralism that should give the evangelists of decentralization-as-democratization pause for thought. At stake is, once again, the “authority to act” and, with it, the question of action itself.
Online Learning with an Almost Perfect Expert
Creators: name: Brânzei, Simina
name: Peres, Yuval
Publisher: name: arXiv
Year: 2018
Subjects: subject: Machine Learning (cs.LG)
subject: Data Structures and Algorithms (cs.DS)
subject: Computer Science and Game Theory (cs.GT)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: We study the multiclass online learning problem where a forecaster makes a sequence of predictions using the advice of $n$ experts. Our main contribution is to analyze the regime where the best expert makes at most $b$ mistakes and to show that when $b = o(\log_4{n})$, the expected number of mistakes made by the optimal forecaster is at most $\log_4{n} + o(\log_4{n})$. We also describe an adversary strategy showing that this bound is tight and that the worst case is attained for binary prediction.
Design, synthesis, biological evaluation and molecular docking of cyclic biguanidine compounds as cholinesterase inhibitors
Creators: name: Gungor, Ozge
name: Kose, Muhammet
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biochemistry
Neuroscience
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified

description: A series of cyclic biguanidine derivatives (E01–E16) was designed, synthesized, characterized by FTIR, NMR, elemental analysis and evaluated as cholinesterase [acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE)] inhibitory effects for the treatment of Alzheimer’s disease (AD). The cyclic biguanidine derivatives (E01–E16) were obtained as hydrochloride salt from one-pot reaction of 2-cyanoguanidine, p-substitute aniline derivatives and cyclohexanone/4-ethylcyclohexanone in the acidic medium. The crystal structures of compounds E13 and E16 were determined by XRD studies. The in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory assessment of the compounds revealed that compounds showed considerable inhibitory activity. The substitute groups on the phenyl rings have an impact on the inhibitory activity of the compounds. Compound E08, containing an ester group on the phenyl ring, showed the highest inhibitory activity against BuChE (IC50: 97.97 ± 0.13 µM) compared to other compounds. According to the docking result, compound E08 exhibited higher binding affinity (−10.17 kcal/mol) against BuChE than the standard drug tacrine (−7.02 kcal/mol). Compound E08 was orientated towards the active site of the enzyme BuChE. Communicated by Ramaswamy H. Sarma
Introducing the SPIN visualization tool
Creators: name: Nieuwenhuis, R.
name: Nelson, K.
name: Fredriksson, D.
Publisher: name: Zenodo
Year: 2020

description: The social policy indicator database (SPIN) provides social policy data across various areas of social policy, for over 40 countries and with trends sometimes going back to 1930 (Nelson et al., 2020). These data are primarily used in academic research, but are also of relevance to a wider audience. To open up the data for this audience, and thus increase the outreach of the data collection efforts, an online visualization tool is developed. The SPIN visualization tool is now available, and will be the foundation to a publicly available visualization tool for anyone interested to access SPIN data. This document outlines the background rationale behind the chosen approach, describes some alternatives, and shows what the SPIN visualization tool looks like.
Practice Abstracts BRANCHES PROJECT H2020 - PA3
Creators: name: Raffaele Spinelli (CNR- IBE), Team ITABIA
Publisher: name: Zenodo
Year: 2022
Subjects: Bioenergy Pellet production Local economy

description: Small-scale Pellet Production - Vertical Integration in the Forest-Wood Chain
description: BRANCHES will produce and share more than 50 case studies, considered Best Practices. The selected case studies will be summarized in Practice Abstracts (PAs), documents tailored for practitioners, shared through the project media and collected on this webpage. The numbering of the PAs only refers to chronological order of uploading. Enjoy your reading!
Evidence for a receding dust sublimation region around a supermassive black hole
Creators: name: Kishimoto, Makoto
name: Hoenig, Sebastian F.
name: Antonucci, Robert
name: Millan-Gabet, Rafael
name: Barvainis, Richard
name: Millour, Florentin
name: Kotani, Takayuki
name: Tristram, Konrad R. W.
name: Weigelt, Gerd
Publisher: name: arXiv
Year: 2013
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The near-IR emission in Type 1 AGNs is thought to be dominated by the thermal radiation from dust grains that are heated by the central engine in the UV/optical and are almost at the sublimation temperature. A brightening of the central source can thus further sublimate the innermost dust, leading to an increase in the radius of the near-IR emitting region. Such changes in radius have been indirectly probed by the measurements of the changes in the time lag between the near-IR and UV/optical light variation. Here we report direct evidence for such a receding sublimation region through the near-IR interferometry of the brightest Type 1 AGN in NGC4151. The increase in radius follows a significant brightening of the central engine with a delay of at least a few years, which is thus the implied destruction timescale of the innermost dust distribution. Compiling historic flux variations and radius measurements, we also infer the reformation timescale for the inner dust distribution to be several years in this galactic nucleus. More specifically and quantitatively, we find that the radius at a given time seems to be correlated with a long-term average of the flux over the previous several (~6) years, instead of the instantaneous flux. Finally, we also report measurements of three more Type 1 AGNs newly observed with the Keck interferometer, as well as the second epoch measurements for three other AGNs.
description: 6 pages, 4 figures, accepted for publication in ApJ Letter
MPEC 2025-C71 : 2022 BV6
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2025
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
N=1 Supersymmetric Non-Abelian Compensator Mechanism for Extra Vector Multiplet
Creators: name: Nishino, Hitoshi
name: Rajpoot, Subhash
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We present a variant formulation of N=1 supersymmetric compensator mechanism for an arbitrary non-Abelian group in four dimensions. This formulation resembles our previous variant supersymmetric compensator mechanism in 4D. Our field content consists of the three multiplets: (i) A Non-Abelian Yang-Mills multiplet (A_μ^I, λ^I, C_{μνρ}^I), (ii) a tensor multiplet (B_{μν}^I, χ^I, φ^I) and an extra vector multiplet (K_μ^I, ρ^I, C_{μνρ}^I) with the index I for the adjoint representation of a non-Abelian gauge group. The C_{μνρ}^I is originally an auxiliary field dual to the conventional auxiliary field D^I for the extra vector multiplet. The vector K_μ^I and the tensor C_{μνρ}^I get massive, after absorbing respectively the scalar φ^I and the tensor B_{μν}^I. The superpartner fermion ρ^I acquires a Dirac mass shared with χ^I. We fix all non-trivial cubic interactions in the total lagrangian, all quadratic terms in supersymmetry transformations, and all quadratic interactions in field equations. The action invariance and the super-covariance of all field equations are confirmed up to the corresponding orders.
description: 11 pages, no figures
Additional file 3 of Surface and deep learning: a blended learning approach in preclinical years of medical school
Creators: name: Khong, Mei Li
name: Tanner, Julian Alexander
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Astronomical and Space Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Supplementary Material 3. Additional file 3: Interview guide.
Quantitative and functional post-translational modification proteomics reveals that TREPH1 plays a role in plant thigmomorphogenesis
Creators: name: Wang, Kai
name: Yang, Zhu
name: Qing, Dongjin
name: Ren, Feng
name: Liu, Shichang
name: Zheng, Qingsong
name: Liu, Jun
name: Zhang, Weiping
name: Dai, Chen
name: Wu, Madeline
name: Chehab, E. Wassim
name: Braam, Janet
name: Li, Ning
Publisher: name: arXiv
Year: 2018
Subjects: subject: Genomics (q-bio.GN)
subject: FOS: Biological sciences

description: Plants can sense both intracellular and extracellular mechanical forces and can respond through morphological changes. The signaling components responsible for mechanotransduction of the touch response are largely unknown. Here, we performed a high-throughput SILIA (stable isotope labeling in Arabidopsis)-based quantitative phosphoproteomics analysis to profile changes in protein phosphorylation resulting from 40 seconds of force stimulation in Arabidopsis thaliana. Of the 24 touch-responsive phosphopeptides identified, many were derived from kinases, phosphatases, cytoskeleton proteins, membrane proteins and ion transporters. TOUCH-REGULATED PHOSPHOPROTEIN1 (TREPH1) and MAP KINASE KINASE 2 (MKK2) and/or MKK1 became rapidly phosphorylated in touch-stimulated plants. Both TREPH1 and MKK2 are required for touch-induced delayed flowering, a major component of thigmomorphogenesis. The treph1-1 and mkk2 mutants also exhibited defects in touch-inducible gene expression. A non-phosphorylatable site-specific isoform of TREPH1 (S625A) failed to restore touch-induced flowering delay of treph1-1, indicating the necessity of S625 for TREPH1 function and providing evidence consistent with the possible functional relevance of the touch-regulated TREPH1 phosphorylation. Bioinformatic analysis and biochemical subcellular fractionation of TREPH1 protein indicate that it is a soluble protein. Altogether, these findings identify new protein players in Arabidopsis thigmomorphogenesis regulation, suggesting that protein phosphorylation may play a critical role in plant force responses.
Spontaneous and Directed Symmetry Breaking in the Formation of Chiral Nanocrystals
Creators: name: Hananel, Uri
name: Ben-Moshe, Assaf
name: Diamant, Haim
name: Markovich, Gil
Publisher: name: arXiv
Year: 2018
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Biological Physics (physics.bio-ph)
subject: Biomolecules (q-bio.BM)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: The homochirality of biomolecules remains one of the outstanding puzzles concerning the beginning of life. Chiral amplification of a randomly perturbed racemic mixture of chiral molecules is a well-accepted prerequisite for all routes to biological homochirality. Some models have suggested that such amplification occurred due to asymmetric discrimination of chiral biotic or prebiotic molecules when they adsorbed onto crystalline surfaces. While chiral amplification has been demonstrated on surfaces of both chiral and achiral crystals, the mechanism that would produce an enantiomeric imbalance in the chiral surfaces themselves has not been addressed. Here we report strong chiral amplification in the colloidal synthesis of intrinsically chiral lanthanide phosphate nanocrystals, quantitatively measured via the circularly polarized luminescence of the lanthanide ions within the nanocrystals. The amplification involves spontaneous symmetry breaking into either left- or right-handed nanocrystals below a critical temperature. Furthermore, chiral tartaric acid molecules in the solution act as an external chiral field, sensitively directing the amplified nanocrystal handedness through a discontinuous transition between left- and right-handed excess. These characteristics suggest a conceptual framework for chiral amplification, based on the statistical thermodynamics of critical phenomena, which we use to quantitatively account for the observations. Our results demonstrate how chiral minerals with high enantiomeric excess could have grown locally in a primordial racemic aqueous environment.
description: 9 pages, 4 figures
Interaction models between peptide substrate and Alphavirus Protease nsP2 of Chikungunya and Mayaro and implications to the mechanism of action
Creators: name: Lima, Jônatas Cunha Barbosa
name: Barbosa, João Alexandre Ribeiro Gonçalves
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: The Arbovirus (Arthropod-borne virus) is a group which comprises viruses whose transmission is carried out by arthropod vectors infecting vertebrates. Some arboviruses related to human diseases have been given considerable relevance as Chikungunya and Mayaro of the family Togaviridae, genus Alphavirus. The lack of proper specific treatment has prompted the requirement for deeper structural studies that could unveil leads to new drugs. Among possible targets, viral proteases are recognized as proteins with big potential. These proteins, termed nsP2 in Alphavirus, have the function of cleaving certain regions of the viral polyprotein, being vital to the viral cycle. In this research, we used docking and molecular dynamics to analyze the contact between the protease nsP2 of Alphavirus Chikungunya and Mayaro and substrates formed by peptides with ten amino acid residues. A model of the Mayaro nsP2 was constructed based on homologous proteases. Our study suggests that the glycine specificity motif, a region where a highly conserved glycine residue in position P2 of the protease substrate is positioned, facilitates the nucleophilic attack by assisting in placing the P1 carbonyl group carbon. Stabilization of different substrate regions maybe explained by relevant contacts with the enzyme. Besides that, the phi and psi angles in the outlier region of the Ramachandran plot found for the P2 glycine of the Chikungunya substrate seems to indicate the necessity of this residue that can accommodate angles not allowed to other residues. Communicated by Ramaswamy H. Sarma
On the feasibility of saltational evolution
Creators: name: Katsnelson, Mikhail I.
name: Wolf, Yuri I.
name: Koonin, Eugene V.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: FOS: Biological sciences

description: Is evolution always gradual or can it make leaps? We examine a mathematical model of an evolutionary process on a fitness landscape and obtain analytic solutions for the probability of multi-mutation leaps, that is, several mutations occurring simultaneously, within a single generation in one genome, and being fixed all together in the evolving population. The results indicate that, for typical, empirically observed combinations of the parameters of the evolutionary process, namely, effective population size, mutation rate, and distribution of selection coefficients of mutations, the probability of a multi-mutation leap is low, and accordingly, the contribution of such leaps is minor at best. However, we show that, taking sign epistasis into account, leaps could become an important factor of evolution in cases of substantially elevated mutation rates, such as stress-induced mutagenesis in microbes. We hypothesize that stress-induced mutagenesis is an evolvable adaptive strategy.
description: Extended version, in particular, the section is added on non-equilibrium model of stress-induced mutagenesis
Talpidae G. Fischer 1814
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Insectivora
Talpidae

description: Family Talpidae REVIEWED BY: O. L. Rossolimo (OLR)(U.S. S.R.); R. G. Van Gelder (RGVG); S. Wang (SW)(China). COMMENT: Revised by Gureev, 1979. Desmana and Galemys are sometimes placed in a separate family, Desmanidae; see Bobrinskii, et al., 1965:43; Flint et al., 1965:27. ISIS NUMBER: 5301403006000000000.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Insectivora, pp. 58-106 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 102, DOI: 10.5281/zenodo.7353001
description: {"references": ["Gureev, A. A. 1979. Fauna SSSR, Mlekopitayutschie, tom. 4, vyp. 2. Nasekomoyadnye ... [Fauna of the USSR, Mammals, vol. 4, pt. 2. Insectivores (Mammalia, Insectivora)]. Nauka, Leningrad, 501 pp. (in Russian)."]}
Additional file 2 of Surface and deep learning: a blended learning approach in preclinical years of medical school
Creators: name: Khong, Mei Li
name: Tanner, Julian Alexander
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Astronomical and Space Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Supplementary Material 2. Additional file 2: LE questionnaire.