cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Zwischen digitalisierter Freiheit und Kontrolle
Creators: name: Bai, Yuqi
Year: 2024

description: Welchen Einfluss haben das Internet und die Sozialen Medien auf die politische Einstellung und die politische Partizipation der Chines:innen auf Festlandchina? Im Zuge der Digitalisierung sind über die Internetsphäre und die Plattformen der Sozialen Medien Räume geschaffen worden, in denen sich die chinesischen Internetnutzer:innen politisch untereinander sowie mit staatlichen Akteur:innen austauschen können. Des Weiteren können über die Internetsphäre kollektive Aktionen (z.B. Proteste) organisiert werden. Dadurch eignet sich die chinesische Internetbevölkerung Mitspracherecht in politischen Themen an und kann Veränderungen im politischen Handeln des Staates erreichen. Gleichzeitig hält der chinesische Staat die Zügel über Kontrolle und Überwachung der Internetsphäre und der chinesischen Bevölkerung und versucht, mit „harten“ und „soften“ Maßnahmen die öffentliche Meinung zu regulieren und ihre eigene Legitimität aufrechtzuerhalten. Mit dem Konzept der „flüchtigen Moderne“ (engl. „liquid modernity“) von Zygmunt Bauman als theoretischer Rahmen wird die Veränderungen der Beziehung zwischen dem chinesischen Staat und seine Bürger:innen untersucht und erklärt.
description: What influence do the internet and social media have on the political attitudes and political participation of Chinese in mainland China? In the course of digitalisation, the internet sphere and social media platforms have opened up spaces in which Chinese internet users can exchange political views with each other and with state actors. Furthermore, collective actions (e.g. protests) can be organised via the internet sphere. In this way, the Chinese internet population acquires a voice in political issues and can achieve changes in the political actions of the state. At the same time, the Chinese state holds the reins over control and surveillance of the internet sphere and the Chinese population and tries to regulate public opinion and maintain its legitimacy with "hard" and "soft" measures. Using Zygmunt Bauman's concept of "liquid modernity" as a theoretical framework, the changes in the relationship between the Chinese state and its citizens are examined and explained.
T-system and thermodynamic Bethe ansatz equations for solvable lattice models associated with superalgebras
Creators: name: Tsuboi, Zengo
Publisher: name: arXiv
Year: 2009
Subjects: subject: Mathematical Physics (math-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: High Energy Physics - Theory (hep-th)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences

description: An analytic Bethe ansatz is carried out related to the Lie superalgebra osp(1|2s). We present an eigenvalue formula of a transfer matrix in dressed vacuum form (DVF) labeled by a Young (super) diagram. Remarkable duality among DVFs is found. A complete set of transfer matrix functional relations (T-system) is proposed as a reduction of a Hirota-Miwa equation. We also derive a thermodynamic Bethe ansatz (TBA) equation from this T-system and the quantum transfer matrix method. This TBA equation is identical to the one from the string hypothesis.
description: 16 pages; submitted to the proceedings of the workshop: `Bilinear Method in the Study of Integrable Systems and Related Topics', RIMS, Kyoto, July, 2001; v2: a reference added
Estimation of cosmological parameters using adaptive importance sampling
Creators: name: Wraith, Darren
name: Kilbinger, Martin
name: Benabed, Karim
name: Cappé, Olivier
name: Cardoso, Jean-François
name: Fort, Gersende
name: Prunet, Simon
name: Robert, Christian P.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Computation (stat.CO)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: We present a Bayesian sampling algorithm called adaptive importance sampling or Population Monte Carlo (PMC), whose computational workload is easily parallelizable and thus has the potential to considerably reduce the wall-clock time required for sampling, along with providing other benefits. To assess the performance of the approach for cosmological problems, we use simulated and actual data consisting of CMB anisotropies, supernovae of type Ia, and weak cosmological lensing, and provide a comparison of results to those obtained using state-of-the-art Markov Chain Monte Carlo (MCMC). For both types of data sets, we find comparable parameter estimates for PMC and MCMC, with the advantage of a significantly lower computational time for PMC. In the case of WMAP5 data, for example, the wall-clock time reduces from several days for MCMC to a few hours using PMC on a cluster of processors. Other benefits of the PMC approach, along with potential difficulties in using the approach, are analysed and discussed.
description: 17 pages, 11 figures
Facile one-pot hydrothermal synthesis of a zinc oxide/curcumin nanocomposite with enhanced toxic activity against breast cancer cells
Creators: name: Madeo, Lorenzo Francesco
name: Schirmer, Christine
name: Cirillo, Giuseppe
name: Froeschke, Samuel
name: Hantusch, Martin
name: Curcio, Manuela
name: Nicoletta, Fiore Pasquale
name: Büchner, Bernd
name: Mertig, Michael
name: Hampel, Silke
Publisher: name: London : RSC Publishing
Year: 2023
Subjects: subject: Cancer cells
subject: Cells
subject: Diseases
subject: Hydrothermal synthesis
subject: II-VI semiconductors
subject: Particle size analysis
subject: Scanning electron microscopy
subject: Thermogravimetric analysis
subject: X ray photoelectron spectroscopy
subject: 540

description: Zinc oxide/Curcumin (Zn(CUR)O) nanocomposites were prepared via hydrothermal treatment of Zn(NO3)2 in the presence of hexamethylenetetramine as a stabilizing agent and CUR as a bioactive element. Three ZnO : CUR ratios were investigated, namely 57 : 43 (Zn(CUR)O-A), 60 : 40 (Zn(CUR)O-B) and 81 : 19 (Zn(CUR)O-C), as assessed by thermogravimetric analyses, with an average hydrodynamic diameter of nanoaggregates in the range of 223 to 361 nm. The interaction of CUR with ZnO via hydroxyl and ketoenol groups (as proved by X-ray photoelectron spectroscopy analyses) was found to significantly modify the key properties of ZnO nanoparticles with the obtainment of a bilobed shape (as shown by scanning electron microscopy), and influenced the growth process of the composite nanoparticles as indicated by the varying particle sizes determined by powder X-ray diffraction. The efficacy of Zn(CUR)O as anticancer agents was evaluated on MCF-7 and MDA-MB-231 cancer cells, obtaining a synergistic activity with a cell viability depending on the CUR amount within the nanocomposite. Finally, the determination of reactive oxygen species production in the presence of Zn(CUR)O was used as a preliminary evaluation of the mechanism of action of the nanocomposites.
FUNCTIONAL AND STRUCTURAL CHARACTERIZATION OF MYOSIN VI ISOFORMS
Creators: name: BIANCOSPINO, MATTEO
Publisher: name: Universit� degli Studi di Milano
Year: 2016

description: Myosin VI is unique among the many members of the myosin superfamily. The peculiarities of this motor protein reside on its ability to travel along actin microfilaments towards their pointed- end, as well as its capacity to act either as anchor or as processive motor. As a consequence, myosin VI has been implicated in clathrin-mediated endocytosis, vesicle trafficking, autophagy, cell migration and tumorigenesis. The current understanding of the myosin VI protein does not explain how it carries out these diverse processes, as functional mechanistic studies are lacking. Alternative splicing in the tail region generates myosin VI molecules with different features (myosin VIshort and myosin VIlong) but little is known about the impact of the variable region on physiological and pathological functions of myosin VI. In this study, we have analysed the myosin VI isoforms from a molecular and a functional perspective. Using quantitative mass spectrometry approach and modern NMR we identified and structurally characterized clathrin light chain as novel and isoform-specific interactor. Within the novel clathrin-binding domain that is unique to myosin VIlong, an isoform-specific regulatory helix, named ?2-linker, defines a specific myosin VIlong conformation. Its presence or absence determines the target selectivity of myosin VIshort and myosin VIlong isoforms, acting like a molecular switch that regulates their functional involvement in migratory or endocytic pathways, respectively. The adaptor-binding RRL motif is embedded in the clathrin-binding domain and is masked in the structural configuration adopted by the myosin VIlong. Consequently, the previously identified RRL interactors show selective binding to myosin VIshort. Thus, we can provide for the first time a mechanistic explanation of why the various isoforms show different localization and function (i.e. myosin VIlong selectively involved in clathrin-mediated endocytosis). We also found that alternative myosin VI splicing is aberrantly regulated in ovarian cancers, where exon skipping dictates myosin VIshort-only expression. Importantly, cancer cell lines selectively expressing the myosin VIshort isoform exhibit severe migration defects when myosin VI is knocked down.
�SYNTHETIC STUDIES TOWARDS BIOACTIVE FUNGAL METABOLITES�
Creators: name: LAHORE, SANTOSH
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: The problem of the development of new pesticides is very urgent, mainly because of the appearance of pest forms resistant to permitted pesticides and for the strict requirements in terms of their safety for people and the environment. Small molecules produced in biological contexts have been, and still are, a large reservoir of new biologically active substances, which can become scaffolds for the discovery of new agrochemicals. The aim of this PhD work was to synthesize naturally occurring potentially antifungal and herbicidal compounds and to test their biological activity. Efforts mainly focused towards the total synthesis of Bulgarein, a fungal metabolite produced by the fungus Bulgaria inquinans. Bulgarein possesses a benzo[j]fluoranthene skeleton, that can be found in a number of polyketide-derived fungal metabolites endowed with significant biological activity, in particular inhibition of Topoisomerase I. As no attempt to synthesize any of these compounds has been reported in literature so far, a synthetic sequence to the benzo[j]fluoranthene nucleus has been developed. Crucial steps for our strategy include a Suzuki coupling followed by a McMurry ring closure. The approach is modular and rapid and can be utilized to synthesize natural products, biologically active analogues or building blocks for the preparation of materials. Following this strategy, the first total synthesis of the recently isolated natural product benzo[j]fluoranthene-4,9-diol was carried out. Efforts were made to adapt the sequence for the synthesis of Bulgarein and other variously substituted compounds with this skeleton. As a second topic in this research, attention was dedicated to another natural compound, Farinomalein A, a structurally rather simple maleimide isolated in 2009 from the entomopathogenic fungus Paecilomyces farinosus. Farinomalein shows potent inhibition of Phytophthora sojae, a plant pathogen that every year causes enormous damage to soybean crops. Recently, three new farinomalein derivatives (Farinomalein C, D & E) were isolated from an endophyte from the mangrove plant Avicennia marina, growing in Oman. Due to the interesting antifungal activity of this class of compounds, a practical synthesis of farinomalein A was developed, which may have value in the large-scale preparation of the natural compound. Starting from farinomalein A, all the three derivatives were successfully synthesized . The antifungal activity of the derivatives was evaluated against Cladosporium cladosporioides and other pathogenic fungi. An approach to the synthesis of Ascaulitoxin, a phytotoxic metabolite produced by the fungus Ascochyta caulina, was also developed.
Dyonic AdS black holes from magnetohydrodynamics
Creators: name: Caldarelli, Marco M.
name: Dias, Oscar J. C.
name: Klemm, Dietmar
Publisher: name: arXiv
Year: 2008
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We use the AdS/CFT correspondence to argue that large dyonic black holes in anti-de Sitter spacetime are dual to stationary solutions of the equations of relativistic magnetohydrodynamics on the conformal boundary of AdS. The dyonic Kerr-Newman-AdS_4 solution corresponds to a charged diamagnetic fluid not subject to any net Lorentz force, due to orthogonal magnetic and electric fields compensating each other. The conserved charges, stress tensor and R-current of the fluid are shown to be in exact agreement with the corresponding quantities of the black hole. Furthermore, we obtain stationary solutions of the Navier-Stokes equations in four dimensions, which yield predictions for (yet to be constructed) charged rotating black strings in AdS_5 carrying nonvanishing momentum along the string. Finally, we consider Scherk-Schwarz reduced AdS gravity on a circle. In this theory, large black holes and black strings are dual to lumps of deconfined plasma of the associated CFT. We analyze the effects that a magnetic field introduces in the Rayleigh-Plateau instability of a plasma tube, which is holographically dual to the Gregory-Laflamme instability of a magnetically charged black string.
description: 38 pages, 1 figure. Refs. added
RNA DEPENDENT RNA POLYMERASE: A VALUABLE TARGET TO BLOCK VIRAL REPLICATION IN SINGLE-STRANDED (+)SENSE RNA VIRUSES.
Creators: name: CROCI, ROMINA
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: The (+)strand RNA viruses include a very large group of viruses that cause epidemic diseases in humans, including dengue fever and gastroenteritis. The human (+)RNA viruses include Flaviviruses (FV) and Norovirus (NV). Both encode for proteins essential for viral replication, such as the RNA dependent RNA polymerase (RdRp). Since human cells lack RdRp, it appears as one of the most promising targets for antivirals development. I worked on the identification of new non-nucleotide inhibitors against FV and NV, using RdRp as the main target. In this context, suramin and NF023 have been identified in my lab as NV RdRp inhibitors that, however both are hampered in their application by pharmacokinetics problems. To overcome such problems, I analyzed the potential inhibitory role of Naf2, a fragment derived from these two molecules. Although Naf2 showed a low inhibitory activity, the crystal structures of NV RdRp/Naf2 complex revealed a new binding site. To further map this new site, I tested a Naf2 related molecule, PPNDS. The crystal structures of the RdRp/PPNDS complex revealed interesting features about the new binding site. I also focused on structurally related molecules synthesized following structure-driven information. NV RdRp crystal structures in complex with one of these compounds (Cpd6) were analyzed, providing new knowledge on the interactions between a small fragment and NV RdRps, establishing a platform for structure-guided drug optimization. In parallel to the NV work, I screened in silico a library of compounds against FV RdRp. One of the best compounds identified (HeE1-2Tyr) was able to inhibit the RdRp activity and several FVs in cell-based assays. Although the crystallographic analyses don't reveal clear enough electron density for the inhibitor, indirect evidence suggests that HeE1-2Tyr interferes with the RdRp priming loop that appears disordered.
Report on the database and the methodology of the OSH policy indicators
Creators: name: Guisset, Anne
name: Lenaerts, Karolien
Publisher: name: Zenodo
Year: 2021

description: This report looks into the methodology of compiling occupational safety and health (OSH) policy indicators to be found in a selection of relevant databases. This study has to be situated as part of the InGRID-2 project and specifically of the work package 13, whose purpose is to develop indicators and valorisation tools for research infrastructures. It builds on work delivered in the first InGRID project, which prepared inventories of comparative policy databases. These inventories showed that comparative text bases exist on OSH policies, but the development of policy indicators, based on this information, is a ‘black box’. This report in particular aims to develop OSH policy indicators on basis of existing international text databases which can be linked to existing working conditions databases.
ASSICURAZIONE DEI RISCHI DA CATASTROFE NATURALE: SCENARIO ITALIANO E REALT� STRANIERE
Creators: name: MEMOLA, ANNA TERESA
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: THE THESIS, WITH A COMPARATIVE APPROACH, EXAMINES THE ISSUE OF THE INSURANCE OF NATURAL CATASTROPHES IN ITALIAN LAW AND DOCTRINE.THE AUTHOR DEALS WITH THE MAIN SOLUTIONS AVAILABLE ON THE INSURANCE MARKET AND EXPOSES THE MAIN DIFFICULTIES OF THE STATE TOWARDS NATURAL CATASTROPHES DAMAGES.
Direct evidence of dust growth in L183 from MIR light scattering
Creators: name: Steinacker, J.
name: Pagani, L.
name: Bacmann, A.
name: Guieu, S.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Theoretical arguments suggest that dust grains should grow in the dense cold parts of molecular clouds. Evidence of larger grains has so far been gathered in near/mid infrared extinction and millimeter observations. Interpreting the data is, however, aggravated by the complex interplay of density and dust properties (as well as temperature for thermal emission). We present new Spitzer data of L183 in bands that are sensitive and insensitive to PAHs. The visual extinction AV map derived in a former paper was fitted by a series of 3D Gaussian distributions. For different dust models, we calculate the scattered MIR radiation images of structures that agree agree with the AV map and compare them to the Spitzer data. The Spitzer data of L183 show emission in the 3.6 and 4.5 micron bands, while the 5.8 micron band shows slight absorption. The emission layer of stochastically heated particles should coincide with the layer of strongest scattering of optical interstellar radiation, which is seen as an outer surface on I band images different from the emission region seen in the Spitzer images. Moreover, PAH emission is expected to strongly increase from 4.5 to 5.8 micron, which is not seen. Hence, we interpret this emission to be MIR cloudshine. Scattered light modeling when assuming interstellar medium dust grains without growth does not reproduce flux measurable by Spitzer. In contrast, models with grains growing with density yield images with a flux and pattern comparable to the Spitzer images in the bands 3.6, 4.5, and 8.0 micron.
description: 13 pages, 11 figures, accepted for publication in Astronomy and Astrophysics
Presentazione del volume
Creators: name: Rozo Acuña, Eduardo
Publisher: name: Studi Urbinati, A - Scienze giuridiche, politiche ed economiche
Year: 2013

description: Da sempre la cultura sollecita e richiama la scuola al compito più alto della divulgazione scientifica, ad ogni livello, con particolare attenzione a quello universitario, cui spetta di diffondere la conoscenza dei momenti del nostro tempo ed a cui insigni studiosi hanno dedicato gran parte della loro vita. Uno di questi fu il professor Giovanni Gualandi, docente dell’ateneo Urbinate dal 1965 al 1996, uno dei miei predecessori, quale Preside della Facoltà di Giurisprudenza, per ben 14 anni, prima di passare all’Università di Bologna dove concluse la sua carriera.
description: Studi Urbinati, A - Scienze giuridiche, politiche ed economiche, V. 60, N. 1 (2009): I libri di Giovanni Gualandi
Highly structured wind in Vela X-1
Creators: name: Kreykenbohm, I.
name: Wilms, J.
name: Kretschmar, P.
name: Torrejon, J. M.
name: Pottschmidt, K.
name: Hanke, M.
name: Santangelo, A.
name: Ferrigno, C.
name: Staubert, R.
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present an in-depth analysis of the spectral and temporal behavior of a long almost uninterrupted INTEGRAL observation of Vela X-1 in Nov/Dec 2003. In addition to an already high activity level, Vela X-1 exhibited several very intense flares with a maximum intensity of more than 5 Crab in the 20-40 keV band. Furthermore Vela X-1 exhibited several off states where the source became undetectable with ISGRI. We interpret flares and off states as being due to the strongly structured wind of the optical companion: when Vela X-1 encounters a cavity in the wind with strongly reduced density, the flux drops, thus potentially triggering the onset of the propeller effect which inhibits further accretion, thus giving rise to the off states. The required drop in density to trigger the propeller effect in Vela X-1 is of the same order as predicted by theoretical papers for the densities in the OB star winds. The same structured wind can give rise to the giant flares when Vela X-1 encounters a dense blob in the wind. Further temporal analysis reveals that a short lived QPO with a period of ~6800 sec is present. The part of the light curve during which the QPO is present is very close to the off states and just following a high intensity state, thus showing that all these phenomena are related.
description: Accepted for publication in the proceedings of the "7th INTEGRAL Workshop - An INTEGRAL View of Compact Objects", Copenhagen, Denmark, 8-11 September 2008
Comparison of Perron and Floquet eigenvalues in age structured cell division cycle models
Creators: name: Clairambault, Jean
name: Gaubert, Stéphane
name: Lepoutre, Thomas
Publisher: name: arXiv
Year: 2008
Subjects: subject: Analysis of PDEs (math.AP)
subject: Dynamical Systems (math.DS)
subject: Spectral Theory (math.SP)
subject: FOS: Mathematics
subject: 35F05, 35P05, 35P15, 92B05, 92D25

description: We study the growth rate of a cell population that follows an age-structured PDE with time-periodic coefficients. Our motivation comes from the comparison between experimental tumor growth curves in mice endowed with intact or disrupted circadian clocks, known to exert their influence on the cell division cycle. We compare the growth rate of the model controlled by a time-periodic control on its coefficients with the growth rate of stationary models of the same nature, but with averaged coefficients. We firstly derive a delay differential equation which allows us to prove several inequalities and equalities on the growth rates. We also discuss about the necessity to take into account the structure of the cell division cycle for chronotherapy modeling. Numerical simulations illustrate the results.
description: 26 pages
title: Die Rekonstruktion der Pädagogik von Badr ad-Dīn Ibn Ǧamāʿa al-Kinānī
Creators: name: Cancetin, Ömer
Year: 2024

description: Diese Masterarbeit widmet sich der Rekonstruktion der Pädagogik von Badr ad-Dīn ibn Muḥammad ibn Ǧamāʿa al-Kinānī, einem bedeutenden islamischen Gelehrten des Spätmittelalters. Durch die eingehende Analyse seines Werkes Taḏkirat as-sāmiʿ w-al-mutakallim fī adab al-ʿālim w-al-mutaʿllim (Die Erinnerung des Hörenden und Sprechenden an die guten Verhaltensformen des Gelehrten und Lernenden) bietet die vorliegende Arbeit einen kritischen Einblick in die klassischen pädagogischen Ansätze und Erziehungspraktiken im islamischen Bildungswesen. Das historische Bildungskonzept Ibn Ǧamāʿas wird mittels herme-neutischer Methoden auf seine Relevanz für aktuelle pädagogische Diskurse geprüft. Die Arbeit beleuchtet die Eigenschaften und didaktischen Methoden, die von Ibn Ǧamāʿa für Lehrer und Schüler empfohlen wurden, und diskutiert deren Bedeutung für die Bildungsethik und -praxis.
description: This master's thesis is dedicated to reconstructing the pedagogy of Badr ad-Dīn ibn Muḥammad ibn Ǧamāʿa al-Kinānī, a prominent Islamic scholar of the late Middle Ages. Through an in-depth analysis of his work Taḏkirat as-sāmiʿ w-al-mutakallim fī adab al-ʿālim w-al-mutaʿllim (The Memorandum of the Listener and the Speaker on the Etiquette of the Scholar and the Learner) the study provides a critical insight into the classical pedagogical approaches and educational practices in Islamic education. Employing hermeneutic meth-ods, Ibn Ǧamāʿa's historical educational concept is contextualized and examined for its rele-vance to current pedagogical discourses. The thesis highlights the characteristics and di-dactic methods recommended by Ibn Ǧamāʿa for teachers and students, discussing their sig-nificance for educational ethics and practice.
Establishing the kinetics of Escherichia bacteriophage T4 and its target bacterium within the intestinal mucosa of a gnotobiotic mouse model
Creators: name: Pett, Nicola Jacqueline
Publisher: name: University of British Columbia
Year: 2024

description: Bacteriophages (phages) are viruses that infect bacteria with species- and strain-level specificity and are the most abundant biological entities across all known ecosystems. Within bacterial communities, such as those found in the gut microbiota, phages are implicated in regulating microbiota population dynamics and driving bacterial evolution. The specificity of phage-bacterial interactions has generated renewed interest in phage research as a potential alternative strategy to counter the increasing threat of antimicrobial resistant bacteria. While there has been some success in using phage therapy to combat bacterial septic infections, we still do not have the foundational understanding of phage-bacteria-host dynamics within our gut ecosystems that is needed for their safe development. Recent studies demonstrating that phages adhere to intestinal mucus through specific capsid proteins (Hoc) have suggested that phages may protect the underlying epithelium from bacterial invasion, providing a host-extrinsic mechanism to maintain intestinal homeostasis. Here, I build upon these findings to investigate the kinetics between Escherichia bacteriophage T4 (containing a Hoc domain) and its target bacterium, Escherichia coli, within the intestinal tract of a gnotobiotic mouse model. I determined that T4 phage and E. coli can stably coexist within the murine gastrointestinal tract in the absence of other microbes, despite continual phage predation. However, I was unable to conclude that T4 phage retention within the murine gut requires Hoc protein-mediated mucus adhesion. Further, my data suggest that gut-colonising T4 phage elicit a type 1 immune response in the gut-draining lymph nodes, without causing inflammatory disease. Together, these results suggest that T4 phage is well tolerated in the gastrointestinal tract of gnotobiotic mice by the bacterial and metazoan hosts and may contribute to immune system priming.
Resistivity of Graphene Nanoribbon Interconnects
Creators: name: Murali, Raghunath
name: Brenner, Kevin
name: Yang, Yinxiao
name: Beck, Thomas
name: Meindl, James D.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Graphene nanoribbon interconnects are fabricated, and the extracted resistivity is compared to that of Cu. It is found that the average resistivity at a given line-width (18nm
description: 10 pages, 3 figures, to be published in IEEE Electron Device Letters
CHOLESTEROL HOMEOSTASIS: INVOLVEMENT OF HISTONE DEACETYLASES IN THE MOLECULAR REGULATORY PATHWAY OF CHOLESTEROL7ALPHA-HYDROXYLASE
Creators: name: FIORINO, ERIKA
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: Cholesterol Homeostasis: involvement of histone deacetylases in the molecular regulatory pathway of Cholesterol 7?-hydroxylase Cholesterol 7?-Hydroxylase (CYP7A1) is the major check-point of bile acid (BA) biosynthesis, quantitatively the most important route of cholesterol disposal in mammals. BA returning to the liver via enterohepatic circulation repress CYP7A1 expression. BA induce histone deacetylase 7 (HDAC7) translocation to nucleus and the sequential recruitment of HDAC7, 3, 1 and of the corepressor SMRT? creates a repressor complex on the nuclear receptor HNF-4 bound to CYP7A1 promoter in a human hepatoma cell line. Previous results showed that non-selective HDAC inhibitors increase CYP7A1 expression in vitro and in vivo by preventing the negative feedback exerted by BA and reduce serum cholesterol in mice. Based on these seminal findings, our aim was to define the role of specific HDACs and corepressors in the regulation of CYP7A1. To this end, we tested class selective HDAC inhibitors in vitro and in vivo. By using a reporter cell line containing CYP7A1 promoter upstream of luciferase gene, we demonstrated that the class I selective HDAC inhibitor MS275 totally prevented the repressive effect of BA on CYP7A1; class II selective inhibitor MC1568 only elicited a partial recovery of CYP7A1 promoter driven transcription. In addition, MS275 significantly increased liver Cyp7a1 expression in C57Bl/6J mice. A mild induction, albeit not statistically significant, was observed even after SAHA and MS275 treatment. HDAC1, 3 and 7 silencing in the same reporter cell line pointed out the importance of HDAC1 and 7 in the regulation of CYP7A1 transcription To unravel the role of specific HDACs and corepressors we cloned shRNA against Hdac1, 3, 4, 5, 7 and Smrt in adenovectors and we tested them in primary hepatocytes. Hdac1, 7 and Smrt silencing significantly increased Cyp7a1 transcription, highlighting their involvement in the regulation of this gene. Adenoviral infection of C57BL/6J mice confirmed Hdac7 and Smrt as crucial players in the regulation of BA metabolism in vivo. Generation of HDAC7 liver-specific KO mice fed western diet allowed to investigate the role of HDAC7 in vivo: we observed body weight and LDL-cholesterol reduction, increased liver BA consistent with increased Cyp7A1 expression, lower liver lipid accumulation and a major fraction of lipid poor pre-beta HDL profile compared to wild type mice. The results obtained with the investigations performed during my doctorate training show that specific HDACs affect CYP7A1 transcription highlighting their role in the regulation of cholesterol and lipid homeostasis and represent a step forward contributing to shed light on the mechanisms of CYP7A1 regulation and their impact in lipid homeostasis.
Presentazione del Fondo "Giovanni Gualandi"
Creators: name: Mari, Luigi
Publisher: name: Studi Urbinati, A - Scienze giuridiche, politiche ed economiche
Year: 2013

description: Indirizzo di saluto del Preside della Facoltà di Giurisprudenza prof. Luigi Mari in occasione della cerimonia per la donazione della Biblioteca Giovanni Gualandi alla Facoltà di Giurisprudenza di Urbino, il 19 settembre 2006.
description: Studi Urbinati, A - Scienze giuridiche, politiche ed economiche, V. 60, N. 1 (2009): I libri di Giovanni Gualandi
Wall-crossing of D4-branes using flow trees
Creators: name: Manschot, Jan
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The moduli dependence of D4-branes on a Calabi-Yau manifold is studied using attractor flow trees, in the large volume limit of the Kahler cone. One of the moduli dependent existence criteria of flow trees is the positivity of the flow parameters along its edges. It is shown that the sign of the flow parameters can be determined iteratively as function of the initial moduli, without explicit calculation of the flow of the moduli in the tree. Using this result, an indefinite quadratic form, which appears in the expression for the D4-D2-D0 BPS mass in the large volume limit, is proven to be positive definite for flow trees with 3 or less endpoints. The contribution of these flow trees to the BPS partition function is therefore convergent. From non-primitive wall-crossing is deduced that the S-duality invariant partition function must be a generating function of rational, multi-covering invariants instead of integer invariants.
description: 41 pages, 3 figures
TARGETING NOTCH TRAFFICKING IN HUMAN CANCER CELLS: A. PHARMACOLOGIC INHIBITION OF THE VACUOLAR H+ ATPASE REDUCES PHYSIOLOGIC AND ONCOGENIC NOTCH SIGNALING. B. HIGH CONTENT SCREEN FOR NOVEL MODULATORS OF THE NOTCH PATHWAY.
Creators: name: KOBIA, FRANCIS MUNGATHIA
Publisher: name: Universit� degli Studi di Milano
Year: 2016

description: Abstract: Notch signaling is prominently involved in cell fate decision and growth regulation in metazoan tissues. Because of this, Notch is often upregulated in cancer and current efforts point to developing drugs that block its activation. Notch receptor endocytosis towards acidic compartments is a recently appreciated determinant of signaling activation. The Vacuolar H+ ATPase (V-ATPase) is responsible for acidification of endocytic organelles and recently it has been shown that mutants in V-ATPase subunit encoding genes in model organisms display loss of Notch signaling phenotypes. In the first part of my graduate studies, we aimed at discovering whether pharmacologic reduction of V-ATPase activity affected Notch signaling. We found that administration of BafilomycinA1 (BafA1), a highly specific V-ATPase inhibitor decreases Notch signaling during Drosophila and Zebrafish development, and in human cells in culture. In normal breast cells, we have found that BafA1 treatment leads to accumulation of Notch in the endo-lysosomal system, and reduces its processing and signaling activity. In Notch-addicted breast cancer cells, BafA1 treatment reduces growth in cells expressing membrane tethered forms of Notch, while sparing cells expressing cytoplasmic forms. In contrast, V-ATPase inhibition reduces growth of leukemia cells, without affecting Notch activating cleavage. However, consistent with the emerging roles of V-ATPase in controlling multiple signaling pathways, in these cells Akt activation is reduced, as it is also the case in BafA1-treated breast cancer cells. Our data support V-ATPase inhibition as a novel therapeutic approach to counteract tumor growth sustained by signaling pathways regulated at the endo-lysosomal level. The functions of Notch throughout the life of an individual are varied and complex. This complexity is not sufficiently accounted for by the limited core of known Notch signaling components and a growing body of evidence attributes it to additional factors that determine whether, when and how Notch functions within a given context. Considering this, in the second part of my graduate work, we sought to identify novel genes that might influence Notch. Thus, we performed a high content immunofluorescence-based RNA interference screen of a pharmacologically-relevant subset of the human genome. To this end, we monitored how knockdown of specific genes perturbs the localization of the Notch-1 receptor in human breast cells under resting and signaling conditions. Here we present the screen setup, the primary screen results and the candidate follow-up strategy.
title: Forage fish as a predator: summer and fall diet of Atlantic herring in Trinity Bay, Newfoundland
Creators: name: Randall, Jessica R.
Publisher: name: Memorial University of Newfoundland
Year: 2020

description: Atlantic herring (Clupea harengus) is an important forage fish in the Northwest Atlantic. However, the diet of herring in eastern Newfoundland is unknown. I compared plankton assemblages to stomach content and stable isotope analyses of Trinity Bay adult herring collected in the late summer and fall (2017-2019) to characterize diet and selectivity. Amphipods (Themisto spp.) contributed most to herring diets in 2017 and August 2018, while calanoid copepods dominated the diet in late 2018 and 2019. Fish eggs and larvae were consistently observed in stomach contents and were most prevalent in the diet when peak larval densities were observed. Stable isotope analyses found that herring fed on prey at a higher trophic level than zooplankton, supporting the importance of piscivory in adult herring diets. As an adaptive predator, Newfoundland herring are resilient to bottom-up changes and may also exert top-down pressure on the early life stages of other fishes.
Topological optimization of quantum key distribution networks
Creators: name: Alleaume, Romain
name: Roueff, Francois
name: Diamanti, Eleni
name: Lutkenhaus, Norbert
Publisher: name: arXiv
Year: 2009
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: A Quantum Key Distribution (QKD) network is an infrastructure that allows the realization of the key distribution cryptographic primitive over long distances and at high rates with information-theoretic security. In this work, we consider QKD networks based on trusted repeaters from a topology viewpoint, and present a set of analytical models that can be used to optimize the spatial distribution of QKD devices and nodes in specific network configurations in order to guarantee a certain level of service to network users, at a minimum cost. We give details on new methods and original results regarding such cost minimization arguments applied to QKD networks. These results are likely to become of high importance when the deployment of QKD networks will be addressed by future quantum telecommunication operators. They will therefore have a strong impact on the design and requirements of the next generation of QKD devices.
description: 25 pages, 4 figures
BIOMARKERS OF OXIDATIVE STRESS, INFLAMMATION AND ENDOTHELIAL FUNCTION TO STUDY THE ROLE OF BLUEBERRY BIOACTIVE COMPOUNDS IN VITRO AND IN VIVO.
Creators: name: DEL BO', CRISTIAN
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: The objective of the PhD thesis was to study the effect of blueberry and its bioactives in the modulation of biomarkers of oxidative stress, inflammation and endothelial function through in vitro and in vivo approaches. In particular, acute and chronic interventions were exploited in subjects with risk factors for cardiovascular disease to investigate the role of blueberry consumption in the modulation of DNA damage, pro-inflammatory cytokines, reactive hyperemia index, arterial stiffness, nitric oxide. At the same time, anthocyanin and phenolic blueberry fractions were used to explore their ability to reduce lipid accumulation in THP-1 macrophages, and to counteract THP-1 attachment to endothelial cells (HUVEC cell line) following stimulation with pro-inflammatory cytokines. The main results obtained in vivo showed that blueberry intake increased cell resistance against DNA damage and improved endothelial function; on the contrary, no effect was observed on markers of inflammation. The in vitro studies showed the capacity of blueberry bioactives to affect lipid accumulation and THP-1 adhesion to endothelial cells. In conclusion, the studies developed documented the beneficial role of blueberry in the modulation of biomarkers of oxidative stress and endothelial function in subjects exposed to risk factors. In addition, the potential antiatherogenic and antiatherosclerotic effect of blueberry bioactives was supported by the exploited in vitro approach.
Poisson boundary of the discrete quantum group A_u(F)^
Creators: name: Vaes, Stefaan
name: Vennet, Nikolas Vander
Publisher: name: arXiv
Year: 2008
Subjects: subject: Operator Algebras (math.OA)
subject: Probability (math.PR)
subject: FOS: Mathematics

description: We identify the Poisson boundary of the dual of the universal compact quantum group A_u(F) with a measurable field of ITPFI factors.
La formazione. Gli anni romani. (Ricordo di Giovanni Gualandi)
Creators: name: Talamanca, Mario
Publisher: name: Studi Urbinati, A - Scienze giuridiche, politiche ed economiche
Year: 2013

description: È con profonda commozione che, quasi a due anni dalla scomparsa, prendo qui la parola per ricordare Giovanni Gualandi, un amico veramente fraterno, e dell’onore che mi è stato così fatto sono particolarmente grato alla Facoltà di Urbino ed alla collega Anna Maria Giomaro che si è tanto prodigata per organizzare il nostro incontro e, ancor più, per dare vita alla struttura che con tale incontro siamo venuti ad inaugurare. ...
description: Studi Urbinati, A - Scienze giuridiche, politiche ed economiche, V. 60, N. 1 (2009): I libri di Giovanni Gualandi
MULTIDIMENSIONAL POVERTY: THEORY AND EMPIRICS
Creators: name: MEKONNEN, ANDUALEM GOSHU
Publisher: name: Universit� degli Studi di Milano
Year: 2015

description: Paper 2: Individual Specific Weighting Scheme to a Multidimensional Poverty Measure Abstract Weights in the estimation of multidimensional poverty have a central role by showing the relative importance of dimensions. This paper proposed two differentweighting schemes: endowment and distributional based weighting schemes.The later weighting scheme gives more weight to the dimension with small number of deprived individuals. On the other hand, the endowment based weighting scheme gives more weight to the dimension with large number of deprived individuals. The proposed weighting schemes considerboth distributional equity and simultaneous deprivations of indicators. Using the Ethiopian rural household survey (ERHS) data for the year 2004, the paper compared the proposed weighting schemes with the equal weighting scheme approach. The empirical result showed that, the multidimensional poverty index (MPI) estimation using endowment based equity weight has a lower estimate than the equal weighting approach. This happened because the indicators that have a small number of deprived individuals have got a higher weight under the equal weighting approach.
Quantum mechanics in phase space: First order comparison between the Wigner and the Fermi function
Creators: name: Benenti, G.
name: Strini, G.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The Fermi g_F(x,p) function provides a phase space description of quantum mechanics conceptually different from that based on the the Wigner function W(x,p). In this paper, we show that for a peaked wave packet the g_F(x,p)=0 curve approximately corresponds to a phase space contour level of the Wigner function and provides a satisfactory description of the wave packet's size and shape. Our results show that the Fermi function is an interesting tool to investigate quantum fluctuations in the semiclassical regime.
description: 5 pages, 3 figures, added new data and discussion
title: Examining diets, identities, and entanglements of Coast Salish dogs
Creators: name: Sparrow, Anna
Publisher: name: Memorial University of Newfoundland
Year: 2020

description: The Coast Salish of southern Vancouver Island maintained domestic dog populations for over 6000 years. Using a multi-scalar approach, including oral tradition, isotopic dietary analysis of dog remains from six archaeological sites (DiSe-7, DcRu-12, DiSc-1, DjSf-13, DjSf-14, & DjSe-6) and radiocarbon dating, this project addresses the agency of dogs and their unique entanglement and relationships with humans. Through multiple lines of evidence, the interwoven relationships between dogs and their humans are explored and the following questions addressed: 1) what foods were dogs eating? 2) What is the dietary variability on the Pacific Northwest Coast over time and space? 3) How can these data, combined with ancillary lines of archaeological evidence, be used to interpret human-canine entanglement through relational approaches? Stable carbon and nitrogen isotope ratio analyses of 60 samples indicates that dogs were consuming mainly high-trophic marine-based proteins, consistent with previous palaeodietary research in coastal British Columbia, which indicates a primarily high-trophic marine diet for both humans and dogs along the coast. New radiocarbon dates are produced for six sites (two previously undated) indicating long-term associations between species over time and space within the region. The presence and personalities of dog characters from Coast Salish traditional narratives in conjunction with dietary stable isotope data and radiocarbon dates provides us with insights into human-dog relationships in this region.
Additional file 1: of HDAC6 is associated with the formation of aortic dissection in human
Creators: name: Guo, Xian
name: Fang, Ze-Min
name: Wei, Xiang
name: Huo, Bo
name: Yi, Xin
name: Cheng, Cai
name: Chen, Jun
name: Zhu, Xue-Hai
name: Bokha, Anas
name: Jiang, Ding-Sheng
Publisher: name: figshare
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Cancer

description: Table S1. Primers for ChIP-PCR of H3K23ac. (DOCX 14 kb)
Spotlight report on reference budgets, Special Interest Group – EU platform on reference budgets
Creators: name: Penne, T.
name: Goedemé, Tim
Publisher: name: Zenodo
Year: 2021

description: Abstract InGRID-2 supported the establishment of a Special Interest Group on reference budgets. Reference budgets are illustrative priced baskets of goods and services that represent a given living standard. In the context of this Special Interest Group, the EU platform on reference budgets was launched, which brings together producers of reference budgets from European countries. This document describes the vision and mission of the platform, the platform activities that were funded by InGRID-2, the strengths, weaknesses, opportunities and threats of reference budgets research and the platform, as well as a first look at future activities. Members of the platform have decided to install a rotating chair of the platform, while ensuring continuation in the future.
Giovanni Gualandi "accademico" ma non solo
Creators: name: Martini, Remo
Publisher: name: Studi Urbinati, A - Scienze giuridiche, politiche ed economiche
Year: 2013

description: Ho conosciuto Giovanni Gualandi nel 1964, quando mi fu dato un incarico romanistico ad Urbino, dove lui era straordinario già da un anno (incaricato dal 1961) e con il collega Guido Rossi di Storia del diritto italiano dava corpo ad una dura opposizione bolognese nel consiglio di Facoltà, dominato dalla successione di presidi milanesi Pastori, Bognetti e Migliazza, che si erano passati il potere l’un l’altro. ...
description: Studi Urbinati, A - Scienze giuridiche, politiche ed economiche, V. 60, N. 1 (2009): I libri di Giovanni Gualandi