cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Cooling, AGN Feedback and Star Formation in Simulated Cool-Core Galaxy Clusters
Creators: name: Li, Yuan
name: Bryan, Greg L.
name: Ruszkowski, Mateusz
name: Voit, G. Mark
name: O'Shea, Brian W.
name: Donahue, Megan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Numerical simulations of active galactic nuclei (AGN) feedback in cool-core galaxy clusters have successfully avoided classical cooling flows, but often produce too much cold gas. We perform adaptive mesh simulations that include momentum-driven AGN feedback, self-gravity, star formation and stellar feedback, focusing on the interplay between cooling, AGN heating and star formation in an isolated cool-core cluster. Cold clumps triggered by AGN jets and turbulence form filamentary structures tens of kpc long. This cold gas feeds both star formation and the supermassive black hole (SMBH), triggering an AGN outburst that increases the entropy of the ICM and reduces its cooling rate. Within 1-2 Gyr, star formation completely consumes the cold gas, leading to a brief shutoff of the AGN. The ICM quickly cools and redevelops multiphase gas, followed by another cycle of star formation/AGN outburst. Within 6.5 Gyr, we observe three such cycles. There is good agreement between our simulated cluster and the observations of cool-core clusters. ICM cooling is dynamically balanced by AGN heating, and a cool-core appearance is preserved. The minimum cooling time to free-fall time ratio typically varies between a few and $\gtrsim 20$. The star formation rate (SFR) covers a wide range, from 0 to a few hundred $\rm M_{\odot}\, yr^{-1}$, with an average of $\sim 40 \,\rm M_{\odot}\, yr^{-1}$. The instantaneous SMBH accretion rate shows large variations on short timescales, but the average value correlates well with the SFR. Simulations without stellar feedback or self-gravity produce qualitatively similar results, but a lower SMBH feedback efficiency (0.1% compared to 1%) results in too many stars.
description: 16 pages, 13 figures, submitted to ApJ
Supplementary material and methods from Using Captain Scott's Discovery specimens to unlock the past: has Antarctic cyanobacterial diversity changed over the last 100 years?
Creators: name: Jungblut, Anne D.
name: Hawes, Ian
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Ecology

description: Supplementary material and methods
Normal-mode driven exploration of protein domain motions
Creators: name: Sanejouand, Yves-Henri
Publisher: name: arXiv
Year: 2021
Subjects: subject: Biomolecules (q-bio.BM)
subject: FOS: Biological sciences

description: Domain motions involved in the function of proteins can often be well described as a combination of motions along a handfull of low-frequency modes, that is, with the values of a few normal coordinates. This means that, when the functional motion of a protein is unknown, it should prove possible to predict it, since it amounts to guess a few values. However, without the help of additional experimental data, using normal coordinates for generating accurate conformers far away from the initial one is not so straightforward. To do so, a new approach is proposed: instead of building conformers directly with the values of a subset of normal coordinates, they are built in two steps, the conformer built with normal coordinates being just used for defining a set of distance constraints, the final conformer being built so as to match them. Note that this approach amounts to transform the problem of generating accurate protein conformers using normal coordinates into a better known one: the distance-geometry problem, which is herein solved with the help of the ROSETTA software. In the present study, this approach allowed to rebuild accurately six large amplitude conformational changes, using at most six low-frequency normal coordinates. As a consequence of the low-dimensionality of the corresponding subspace, random exploration also proved enough for generating low-energy conformers close to the known end-point of the conformational change of the LAO binding protein, lysozyme T4 and adenylate kinase.
description: 11 pages, 5 figures
BLOOD TRANSFUSION-RELATED PATIENT SAFETY ISSUES
Creators: name: Allouzi, Safa Mousa A
name: Allouzi, Mintallah Mousa A
name: Kim, Wee Boon
name: Chung, Joyce Ling Fun
name: Chin, Wang Xin
name: Teng, Meng Li
name: Oon, Muhammad Haziq Bin
name: Yeong, Kah Hing
name: Chit, Chindy A/P Som
name: Azmani, Muhammad Shirazie Bin
Publisher: name: Zenodo
Year: 2023

description: This research article titled "Blood Transfusion-Related Patient Safety Issues" focuses on the risks associated with blood transfusions, including adverse reactions such as hemolytic transfusion reaction and transfusion-transmitted infections. The study emphasizes the importance of following Malaysia Transfusion Practice Guidelines, patient identification, and labeling procedures to prevent errors and ensure patient safety. The study also highlights that most of the risks associated with blood transfusions are avoidable, and healthcare staff's education on blood transfusion safety and adherence to existing guidelines are imperative to minimize near-miss events. The study concludes by suggesting the need for continuous medical education and routine assessments to maintain patient blood transfusion safety. The study used a literature review of 21 research papers and data from the Patient Safety Council of Malaysia's official report and emphasizes the importance of mandatory reporting and Root Cause Analysis (RCA) for any incident of incorrect blood component transfused (IBCT) or near miss.
Descargar PDF FARMACOLOGIA PARA LICENCIADOS EN ENFERMERIA
Creators: name: Johnson
Publisher: name: Zenodo
Year: 2024

description: FARMACOLOGIA PARA LICENCIADOS EN ENFERMERIA de TERJE SIMONSEN

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FARMACOLOGIA PARA LICENCIADOS EN ENFERMERIA

TERJE SIMONSEN

Número de páginas: 603

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9789707293762

Editorial: MANUAL MODERNO

Año de edición: 2009

 

 

 

 

 

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Overview

Este nuevo ejemplar es una obra completa y muy bien ilustrada que contiene los principios esenciales, tanto teóricos como clínicos, de la farmacología. El entendimientos de cómo funcionan los fármacos y su aplicación en el tratamiento de los pacientes es un conocimiento esencial al ejercer la profesión de enfermería Este libro ofrece de forma clara y actualizada el mecanismo de acción, y efectos de los medicamentos. Incluye también la farmacocinética, efectos secundarios y medidas de precaución en situaciones generales y específicas, desglosando además los aspectos clínicas. El lector encontrara que la obra está ilustrada de forma didáctica, lo que hace un invaluable recurso de aprendizaje, reafirmación de conocimientos y fuente de consulta - Contiene 300 figuras que fortalecen el entendimiento del texto - La obra está integrada de forma concisa y clara - Los conceptos complejos los encontrara de manera clara y fácil - Cada capítulo contiene un resumen de gran utilidad Contiene además un CD con la descripción de medicamentos que forman parte del Cuadro Básico del Sector Salud, del primer nivel de atención para su consulta.
Compression of Correlation Matrices and an Efficient Method for Forming Matrix Product States of Fermionic Gaussian States
Creators: name: Fishman, Matthew T.
name: White, Steven R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Here we present an efficient and numerically stable procedure for compressing a correlation matrix into a set of local unitary single-particle gates, which leads to a very efficient way of forming the matrix product state (MPS) approximation of a pure fermionic Gaussian state, such as the ground state of a quadratic Hamiltonian. The procedure involves successively diagonalizing subblocks of the correlation matrix to isolate local states which are purely occupied or unoccupied. A small number of nearest neighbor unitary gates isolates each local state. The MPS of this state is formed by applying the many-body version of these gates to a product state. We treat the simple case of compressing the correlation matrix of spinless free fermions with definite particle number in detail, though the procedure is easily extended to fermions with spin and more general BCS states (utilizing the formalism of Majorana modes). We also present a DMRG-like algorithm to obtain the compressed correlation matrix directly from a hopping Hamiltonian. In addition, we discuss a slight variation of the procedure which leads to a simple construction of the multiscale entanglement renormalization ansatz (MERA) of a fermionic Gaussian state, and present a simple picture of orthogonal wavelet transforms in terms of the gate structure we present in this paper. As a simple demonstration we analyze the Su-Schrieffer-Heeger model (free fermions on a 1D lattice with staggered hopping amplitudes).
description: 15 pages, 17 figures
Effects of select pharmaceuticals and personal care products (PPCPs) on aquatic organisms and ecosystems
Creators: name: PHUNG, KHANH CHUYEN
Publisher: name: Monash University
Year: 2023
Subjects: Bioavailability and ecotoxicology
Other environmental sciences not elsewhere classified

description: The increasing use of pharmaceuticals and personal care products (PPCPs) worldwide leads to their ubiquitous and continuous presence in the environment, especially in aquatic environments, posing potential risk to the biota and ecosystems. PPCPs occur at very low concentrations and often in mixtures of multi PPCPs. This research aims to examine the ecological effects of selected PPCPs on the green alga Scenedesmus abundans (at individual level), using bioassays in the laboratory and biofilms (at community level), using the pharmaceutical diffusing substrates (PhADS). The results show that the antibiotic ciprofloxacin and the antihistamin diphenhydramine induce chronic effects on the alga, such as suppressed algal respiration, primary production and biomass. Selected PPCPs in both individual and binary mixture forms strongly affects biofilms, presented by negative changes in community respiration and production, biomass and possible structure shifts in autotrophic community.
Measurement of the charge asymmetry in top quark pair production in pp collisions at sqrt(s) = 8 TeV using a template method
Creators: name: CMS Collaboration
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The charge asymmetry in the production of top quark and antiquark pairs is measured in proton-proton collisions at a center-of-mass energy of 8 TeV. The data, corresponding to an integrated luminosity of 19.6 inverse femtobarns, were collected by the CMS experiment at the LHC. Events with a single isolated electron or muon, and four or more jets, at least one of which is likely to have originated from hadronization of a bottom quark, are selected. A template technique is used to measure the asymmetry in the distribution of differences in the top quark and antiquark absolute rapidities. The measured asymmetry is A[c,y] = [0.33 +/- 0.26 (stat) +/- 0.33 (syst)]%, which is the most precise result to date. The results are compared to calculations based on the standard model and on several beyond-the-standard-model scenarios.
description: Replaced with the published version. All of the figures and tables can be found at http://cms-results.web.cern.ch/cms-results/public-results/publications/TOP-13-013/index.html (CMS Public Pages)
The SINFONI Nearby Elliptical Lens Locator Survey: Discovery of two new low-redshift strong lenses and implications for the initial mass function in giant early-type galaxies
Creators: name: Smith, Russell J.
name: Lucey, John R.
name: Conroy, Charlie
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present results from a blind survey to identify strong gravitational lenses among the population of low-redshift early-type galaxies. The SINFONI Nearby Elliptical Lens Locator Survey (SNELLS) uses integral-field infrared spectroscopy to search for lensed emission line sources behind massive lens candidates at $z$<0.055. From 27 galaxies observed, we have recovered one previously-known lens (ESO325-G004) at $z$=0.034, and discovered two new systems, at $z$=0.031 and $z$=0.052. All three lens galaxies have high velocity dispersions (σ>300 km/s) and α-element abundances ([Mg/Fe]>0.3). From the lensing configurations we derive total J-band mass-to-light ratios of 1.8$\pm$0.1, 2.1$\pm$0.1 and 1.9$\pm$0.2 within the $\sim$2 kpc Einstein radius. Correcting for estimated dark-matter contributions, and comparing to stellar population models with a Milky Way (Kroupa) initial mass function (IMF), we determine the "mass excess factor", α. Assuming the lens galaxies have "old" stellar populations (10$\pm$1 Gyr), the average IMF mass factor is $\langleα\rangle$=1.10$\pm$0.08$\pm$0.10, where the first error is random and the second is systematic. If we instead fit the stellar populations from 6dF optical survey spectra, all three galaxies are consistent with being old, but the age errors are 3-4 Gyr, due to limited signal-to-noise. The IMF constraints are therefore looser in this case, with $\langleα\rangle$ = $1.23^{+0.16}_{-0.13}\pm{0.10}$. Our results are thus consistent with a Kroupa IMF (α=1.00) on average, and strongly reject very heavy IMFs with α>2. A Salpeter IMF (α=1.55) is inconsistent at the 3.5$σ$ level if the galaxies are old, but cannot be excluded using age constraints derived from the currently-available optical spectra.
description: Accepted for publication in MNRAS
Table S1 from Using Captain Scott's Discovery specimens to unlock the past: has Antarctic cyanobacterial diversity changed over the last 100 years?.
Creators: name: Jungblut, Anne D.
name: Hawes, Ian
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Ecology

description: Location, description, date and accession numbers of cyanobacteria-based microbial mat samples collected during Captain Scott's Discovery expedition to Antarctica.; Table S2: Location, date of collection, latitude-longitude and properties of cyanobacteria-base microbial mats and properties such as conductivity, temperature and pH; Table S3: Highest uncultured and cultured BLAST similarity match of the 10 most abundant cyanobacterial 16S rRNA genotypes in the historic and modern Antarctic cyanobacterial mat communities; Table S4. Cyanobacterial 16S rRNA genotypes that contribute up to 25% of cumulative dissimilarity based on SIMPER analysis
Download Pdf Sister and Giant: A Young Lady Is Reborn in Another World, Vol. 1 by Be-con, John Thomas Neal
Creators: name: Ross
Publisher: name: Zenodo
Year: 2024

description: Sister and Giant: A Young Lady Is Reborn in Another World, Vol. 1 by Be-con, John Thomas Neal

 

 

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Sister and Giant: A Young Lady Is Reborn in Another World, Vol. 1

Be-con, John Thomas Neal

Page: 208

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ISBN: 9781975378660

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{epub download} Erik Vogler Y Los Crimenes Del Rey Blanco #1 by Beatriz Oses
Creators: name: Alder
Publisher: name: Zenodo
Year: 2024

description: Erik Vogler Y Los Crimenes Del Rey Blanco #1 by Beatriz Oses

 

 

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Erik Vogler Y Los Crimenes Del Rey Blanco #1

Beatriz Oses

Page: 144

Format: pdf, ePub, mobi, fb2

ISBN: 9788468312842

Publisher: Lectorum Publications, Inc.

 

Epub books free download for ipad Erik Vogler Y Los Crimenes Del Rey Blanco #1 (English literature) ePub

 

La ventana de los libros: AfterAnterior 1 2 3 4 5 6 7 8 9 10 Siguiente » Desde que leí la historia del vampiro Edward y la humana Bella, muchas historias han Erik Vogler y los crímenes del rey blanco · Bajo el azul (Saga Waterfire) · Wabi-Sabi, 43 Eltemplo Shelf - GoodreadsErik Vogler y los crímenes del rey blanco · El chico de las manos azules · La puerta (Los señores de los Siete Tronos, #1) · Enciclopedia de Idhún · Famous in  Happiness life: ~ Reseña #130 = Erik Vogler: los crímenes del reyTítulo español: Erik Vogler y los crímenes del rey blanco Libro: 1/ ? El libro se centra en la investigación de el pobre y joven Erik sobre Un escritor dice: Erik Vogler y los crímenes del Rey blancoPara el estrafalario Erik Vogler, maniático del orden y la pulcritud, las cosas no podían empezar peor aquellas vacaciones de Semana Santa: Cuentos similares a ERIK VOGLER 1: LOS CRÍMENES DELlectura infantil. Los libros más vendidos, ebooks y apps, cuentos clásicos, álbum ilustrado. Portada de ERIK VOGLER 1: LOS CRÍMENES DEL BLANCO No en vano, las pesadillas con el "rey blanco" le asediaban casi todas las noches.El Templo's bookshelf: finalista (showing 1-30 of 73) (sorted by: dateposition. cover. El Oráculo de Estépal (La Horda del Diablo, #5) La última cazadora (The Falconer, #1). title Erik Vogler y los crímenes del rey blanco. title .
The Role of Particulate Matter-Associated Zinc in Cardiac Injury in Rats
Creators: name: Thomas, Ronald
name: Runge, Marschall S.
name: Ledbetter, Allen D.
name: Nyska, Abraham
name: Christiani, David C.
name: Jaskot, Richard
name: Schladweiler, Mette C.
name: Kodavanti, Urmila P.
name: Karoly, Edward D.
name: Costa, Daniel L.
name: Peddada, Shyamal
name: Richards, Judy H.
name: Wallenborn, J. Grace
name: Mandavilli, Bhaskar S.
name: Gilmour, Peter S.
name: Madamanchi, Nageswara R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: BackgroundExposure to particulate matter (PM) has been associated with increased cardiovascular morbidity; however, causative components are unknown. Zinc is a major element detected at high levels in urban air.ObjectiveWe investigated the role of PM-associated zinc in cardiac injury.MethodsWe repeatedly exposed 12- to 14-week-old male Wistar Kyoto rats intratracheally (1×/week for 8 or16 weeks) to a) saline (control); b) PM having no soluble zinc (Mount St. Helens ash, MSH); or c) whole-combustion PM suspension containing 14.5 μg/mg of water-soluble zinc at high dose (PM-HD) and d ) low dose (PM-LD), e) the aqueous fraction of this suspension (14.5 μg/mg of soluble zinc) (PM-L), or f ) zinc sulfate (rats exposed for 8 weeks received double the concentration of all PM components of rats exposed for 16 weeks).ResultsPulmonary inflammation was apparent in all exposure groups when compared with saline (8 weeks > 16 weeks). PM with or without zinc, or with zinc alone caused small increases in focal subepicardial inflammation, degeneration, and fibrosis. Lesions were not detected in controls at 8 weeks but were noted at 16 weeks. We analyzed mitochondrial DNA damage using quantitative polymerase chain reaction and found that all groups except MSH caused varying degrees of damage relative to control. Total cardiac aconitase activity was inhibited in rats receiving soluble zinc. Expression array analysis of heart tissue revealed modest changes in mRNA for genes involved in signaling, ion channels function, oxidative stress, mitochondrial fatty acid metabolism, and cell cycle regulation in zinc but not in MSH-exposed rats.ConclusionThese results suggest that water-soluble PM-associated zinc may be one of the causal components involved in PM cardiac effects.
Elevated Human Telomerase Reverse Transcriptase Gene Expression in Blood Cells Associated with Chronic Arsenic Exposure in Inner Mongolia, China
Creators: name: Mo, Jinyao
name: Mumford, Judy L.
name: Wade, Timothy J.
name: Xia, Yajuan
name: Ning, Zhixiong
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Background Arsenic exposure is associated with human cancer. Telomerase-containing human telomerase reverse transcriptase (hTERT) can extend telomeres of chromosomes, delay senescence, and promote cell proliferation leading to tumorigenesis.ObjectiveThe goal of this study was to investigate the effects of As on hTERT mRNA expression in humans and in vitro. Method A total of 324 Inner Mongolia residents who have been exposed to As via drinking water participated in this study. Water and toenail samples were collected and analyzed for As. Blood samples were quantified for hTERT mRNA expression using real-time polymerase chain reaction. The hTERT mRNA levels were linked to water and nail As concentrations and skin hyperkeratosis. Human epidermal keratinocytes were treated with arsenite to assess effects on cell viability and hTERT expression in vitro.ResultshTERT mRNA expression levels were significantly associated with As concentrations of water (p < 0.0001) and nails (p = 0.002) and also associated with severity of skin hyperkeratosis (p < 0.05), adjusting for age, sex, smoking, and pesticide use. Females showed a higher slope than males (females: 0.126, p = 0.0005; males: 0.079, p = 0.017). In addition to water and nail As concentrations, age (p < 0.0001) and pesticide use (p = 0.025) also showed significant associations with hTERT expression. The hTERT expression levels decreased with age. Tobacco smoking did not affect hTERT expression (p = 0.13). hTERT expression was significantly correlated with OGG1 and ERCC1 expression. The in vitro results also showed a dose–response relationship between arsenite concentrations and hTERT expression and reached the peak at 1 μM. Conclusion shTERT expression was associated with As exposure in vivo and in vitro. The increased hTERT expression may be a cellular response to genomic insults by As and may also indicate that As may function as a tumor promoter in carcinogenesis in humans.
Future projections on the anomalous $WWγγ$ couplings in hadron-hadron interactions at the FCC-hh
Creators: name: Gutiérrez-Rodríguez, A.
name: Ari, V.
name: Gurkanli, E.
name: Köksal, M.
name: Hernández-Ruíz, M. A.
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We carry out a study in the approach of a dimension-8 effective field theory on the anomalous quartic $WWγγ$ couplings that arise from the process $pp \to Wγγ$ at the Future Circular Collider-hadron hadron (FCC-hh). The process is sensitive to the $WWγγ$ vertex, and future projections on the anomalous $f_ {M,i}/Λ^4$ and $ f_ {T,j}/Λ^4$ couplings can be put by measurements of $Wγγ$ production. We illustrate the physics opportunities and reach of the FCC-hh operating for a high integrated luminosity scenario of ${\cal L}=1, 5, 10, 30$ ${\rm ab}^{-1}$ of proton-proton collisions at a center-of-mass energy of $\sqrt{s}=100$ TeV and systematic uncertainties of $δ_{sys}=0\%, 3\%, 5\%, 10\%$. Production cross-sections of the signal and the sensitivity constraints on the anomalous $f_ {M,i}/Λ^4$ and $ f_ {T,j}/Λ^4$ couplings at $95\%$ C.L. are identified through the leptonic and hadronic decay modes of the $W$-boson. The FCC-hh sensitivity on these anomalous couplings is expected might reach up to the order of magnitude ${\cal O}(10^{-4}-10^1)$. These sensitivity perspectives indicate that the $pp \to Wγγ$ channel at the FCC-hh has a greater potential to search for the anomalous quartic $WWγγ$ couplings and to search for new physics than present colliders.
description: 29 pages, 8 figures
Table S1 from Using Captain Scott's Discovery specimens to unlock the past: has Antarctic cyanobacterial diversity changed over the last 100 years?
Creators: name: Jungblut, Anne D.
name: Hawes, Ian
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Ecology

description: Location, description, date and accession numbers of cyanobacteria-based microbial mat samples collected during Captain Scott's Discovery expedition to Antarctica’ * Ponds half-way between Black Island and Brown Peninsula; Location, date of collection, latitude-longitude and properties of cyanobacteria-base microbial mats and properties such as conductivity, temperature and pH. Legend: *unofficial names; Highest uncultured and cultured BLAST similarity match of the 10 most abundant cyanobacterial 16S rRNA genotypes in the historic and modern Antarctic cyanobacterial mat communities.; Cyanobacterial 16S rRNA genotypes that contribute up to 25% of cumulative dissimilarity based on SIMPER analysis; OTUs only present in modern samples are marked in bold. Any OTUS present in historic samples only contributed < 25%
Exposure to Concentrated Coarse Air Pollution Particles Causes Mild Cardiopulmonary Effects in Healthy Young Adults
Creators: name: Cascio, Wayne E.
name: Rappold, Ana
name: Huang, Yuh Chin T.
name: Graff, Donald W.
name: Zhou, Haibo
name: Devlin, Robert B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: BackgroundThere is ample epidemiologic and toxicologic evidence that exposure to fine particulate matter (PM) air pollution [aerodynamic diameter ≤ 2.5 μm (PM2.5)], which derives primarily from combustion processes, can result in increased mortality and morbidity. There is less certainty as to the contribution of coarse PM (PM2.5–10), which derives from crustal materials and from mechanical processes, to mortality and morbidity.ObjectiveTo determine whether coarse PM causes cardiopulmonary effects, we exposed 14 healthy young volunteers to coarse concentrated ambient particles (CAPs) and filtered air. Coarse PM concentration averaged 89.0 μg/m3 (range, 23.7–159.6 μg/m3). Volunteers were exposed to coarse CAPs and filtered air for 2 hr while they underwent intermittent exercise in a single-blind, crossover study. We measured pulmonary, cardiac, and hematologic end points before exposure, immediately after exposure, and again 20 hr after exposure.ResultsCompared with filtered air exposure, coarse CAP exposure produced a small increase in polymorphonuclear neutrophils in the bronchoalveolar lavage fluid 20 hr postexposure, indicating mild pulmonary inflammation. We observed no changes in pulmonary function. Blood tissue plasminogen activator, which is involved in fibrinolysis, was decreased 20 hr after exposure. The standard deviation of normal-to-normal intervals (SDNN), a measure of overall heart rate variability, also decreased 20 hr after exposure to CAPs.ConclusionsCoarse CAP exposure produces a mild physiologic response in healthy young volunteers approximately 20 hr postexposure. These changes are similar in scope and magnitude to changes we and others have previously reported for volunteers exposed to fine CAPs, suggesting that both size fractions are comparable at inducing cardiopulmonary changes in acute exposure settings.
The relationship between economic globalization and ecological footprint: empirical evidence for developed and developing countries
Creators: name: Çeliköz, Yıldız Sağlam
name: Yildiz, Tuba
name: Arslan, Ünal
name: Kirmizioğlu, Hale
name: Çeliköz, Yıldız Sağlam
name: Yildiz, Tuba
name: Arslan, Ünal
name: Kirmizioğlu, Hale
Publisher: name: Unknown
Year: 2022
Subjects: subject: Environmental Economics and Policy
subject: ecological footprint
subject: economic globalization
subject: environment
subject: panel analysis

description: Purpose. The aim of this study is to examine the relationship between economic globalization and the ecological footprint in countries with different levels of development using a Feasible Generalized Least Squares (FGLS) analysis. Methodology / approach. The study covers the years 1970 to 2017 for 65 developed and developing countries. The ecological footprint is the dependent variable in the study’s model, and the GDP and KOF Globalization Index (KOF) index are the independent variables. The CADF panel unit root test, which takes into account cross-sectional dependence, was used to choose the appropriate test method for the analysis. Feasible Generalised Least Square and Westerlund ECM panel cointegration analyses were performed for model estimation. Results. Economic globalization and ecological footprint have a considerable relationship, according to the results of FGLS and Westerlund cointegration analysis. Economic globalization has a long-run negative impact on the ecological footprint. Environmental problems are being addressed as a result of more economic globalization, faster technology development, and consequently decreased usage of natural resources. Furthermore, as globalization and communication technologies develop, societies will have more information on the importance of the environment. As a result, they can show more eco-friendly behavior. Originality / scientific novelty. Several studies in the literature include the cointegration relationship between economic globalization and ecological footprint. Although there are few studies on this topic in the literature, one aspect that distinguishes this study is the use of an estimation method that takes into account the cross-sectional dependent, second-generation unit root tests, FGLS cointegration analysis, and Westerlund ECM analysis. Practical value / implications. The importance of the findings is that increased economic globalization has a negative effect on the ecological footprint. As economic globalization increases, so does communication technology, as well as international trade. Individuals become more environmentally conscious as a result of communication, which generally reduces ecological footprint.
Density-tuned isotherms and dynamic change at phase transition in a gate-controlled superconducting system
Creators: name: Sengupta, Shamashis
name: Monteverde, Miguel
name: Murani, Anil
name: Marrache-Kikuchi, Claire
name: Santander-Syro, Andres F.
name: Fortuna, Franck
Publisher: name: arXiv
Year: 2021
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Two-dimensional electron gases in SrTiO3-based heterostructures provide a platform to study the real-time evolution of the macroscopic state with a variation of the carrier density, and the impact of structural properties on the emergence of the superconducting state. We have explored the isothermal evolution of the electron gas in AlOx/SrTiO3 by measuring the variation of resistance with continuous gate-voltage-controlled tuning of its carrier density. It is seen that condensation of the ordered phase leads to non-monotonic isotherms within the superconducting dome. The timescale for dynamic change following changes in gate voltage is measured across the phase transition. It is found to be tens of seconds near the onset of superconductivity, significantly larger compared to the normal state. Such a large timescale governing the kinetics of the phase transition presumably arises from the strong impact of structural defects and distortions of the substrate on the development of superconducting islands.
Sugar and Stops in Drivers with Insulin-Dependent Type 1 Diabetes
Creators: name: Barnwal, Ashirwad
name: Chakraborty, Pranamesh
name: Sharma, Anuj
name: Riera-Garcia, Luis
name: Ozcan, Koray
name: Davami, Sayedomidreza
name: Sarkar, Soumik
name: Rizzo, Matthew
name: Merickel, Jennifer
Publisher: name: arXiv
Year: 2021
Subjects: subject: Applications (stat.AP)
subject: Other Statistics (stat.OT)
subject: FOS: Computer and information sciences

description: Diabetes is a major public health challenge worldwide. Abnormal physiology in diabetes, particularly hypoglycemia, can cause driver impairments that affect safe driving. While diabetes driver safety has been previously researched, few studies link real-time physiologic changes in drivers with diabetes to objective real-world driver safety, particularly at high-risk areas like intersections. To address this, we investigated the role of acute physiologic changes in drivers with type 1 diabetes mellitus (T1DM) on safe stopping at stop intersections. 18 T1DM drivers (21-52 years, mean = 31.2 years) and 14 controls (21-55 years, mean = 33.4 years) participated in a 4-week naturalistic driving study. At induction, each participant's vehicle was fitted with a camera and sensor system to collect driving data. Video was processed with computer vision algorithms detecting traffic elements. Stop intersections were geolocated with clustering methods, state intersection databases, and manual review. Videos showing driver stop intersection approaches were extracted and manually reviewed to classify stopping behavior (full, rolling, and no stop) and intersection traffic characteristics. Mixed-effects logistic regression models determined how diabetes driver stopping safety (safe vs. unsafe stop) was affected by 1) disease and 2) at-risk, acute physiology (hypo- and hyperglycemia). Diabetes drivers who were acutely hyperglycemic had 2.37 increased odds of unsafe stopping (95% CI: 1.26-4.47, p = 0.008) compared to those with normal physiology. Acute hypoglycemia did not associate with unsafe stopping (p = 0.537), however the lower frequency of hypoglycemia (vs. hyperglycemia) warrants a larger sample of drivers to investigate this effect. Critically, presence of diabetes alone did not associate with unsafe stopping, underscoring the need to evaluate driver physiology in licensing guidelines.
description: 18 pages, 3 figures, 8 tables
The 106Cd(alpha,alpha)106Cd elastic scattering in a wide energy range for gamma-process studies
Creators: name: Ornelas, A.
name: Kiss, G. G.
name: Mohr, P.
name: Galaviz, D.
name: Fülöp, Zs.
name: Gyürky, Gy.
name: Máté, Z.
name: Rauscher, T.
name: Somorjai, E.
name: Sonnabend, K.
name: Zilges, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Alpha elastic scattering angular distributions of the 106Cd(alpha,alpha)106Cd reaction were measured at three energies around the Coulomb barrier to provide a sensitive test for the alpha + nucleus optical potential parameter sets. Furthermore, the new high precision angular distributions, together with the data available from the literature were used to study the energy dependence of the locally optimized α+nucleus optical potential in a wide energy region ranging from E_Lab = 27.0 MeV down to 16.1 MeV. The potentials under study are a basic prerequisite for the prediction of alpha-induced reaction cross sections and thus, for the calculation of stellar reaction rates used for the astrophysical gamma process. Therefore, statistical model predictions using as input the optical potentials discussed in the present work are compared to the available 106Cd + alpha cross section data.
Scalar curvature and Futaki invariant of Kähler metrics with cone singularities along a divisor
Creators: name: Hashimoto, Yoshinori
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 53C55

description: We study the scalar curvature of Kähler metrics that have cone singularities along a divisor, with a particular focus on certain specific classes of such metrics that enjoy some curvature estimates. Our main result is that, on the projective completion of a pluricanonical bundle over a product of Kähler--Einstein Fano manifolds with the second Betti number 1, momentum-constructed constant scalar curvature Kähler metrics with cone singularities along the $\infty$-section exist if and only if the log Futaki invariant vanishes on the fibrewise $\mathbb{C}^*$-action, giving a supporting evidence to the log version of the Yau--Tian--Donaldson conjecture for general polarisations. We also show that, for these classes of conically singular metrics, the scalar curvature can be defined on the whole manifold as a current, so that we can compute the log Futaki invariant with respect to them. Finally, we prove some partial invariance results for them.
description: 47 pages, 2 figures. To appear in Ann. Inst. Fourier
Desorption and Bioavailability of PAHs in Contaminated Soil Subjected to Long-Term In Situ Biostimulation
Creators: name: Richardson, Stephen D.
name: Aitken, Michael D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The distribution and potential bioavailability of polycyclic aromatic hydrocarbons (PAHs) in soil from a former manufactured-gas plant (MGP) site were examined before and after long-term biostimulation under simulated in situ conditions. Treated soil was collected from the oxygenated zones of two continuous-flow columns, one subjected to biostimulation and the other serving as a control, and separated into low- and high-density fractions. In the original soil, over 50% of the total PAH mass was associated with lower-density particles, which comprised < 2% of the total soil mass. However, desorbable fractions of PAHs were much lower in the low-density material than in the high-density material. After over 500 d of biostimulation, significant removal of total PAHs occurred in both the high- and low-density materials (77% and 53%, respectively), with three- and four-ring PAHs accounting for the majority of the observed mass loss. Total PAHs that desorbed over a 28-d period were substantially lower in treated soil from the biostimulated column than in the original soil for both the high-density material (23 versus 63%) and low-density material (5 versus 20%). The fast-desorbing fractions quantified by a two-site desorption model ranged from 0.1 to 0.5 for most PAHs in the original soil but were essentially zero in the biostimulated soil. The fast-desorbing fractions in the original soil underestimated the extent of PAH biodegradation observed in the biostimulated column, and thus was not a good predictor of PAH bioavailability after long-term, simulated in situ biostimulation.
The Importance and Role of Intracluster Correlations in Planning Cluster Trials
Creators: name: Song, Eun Young
name: Reboussin, Beth A.
name: Wolfson, Mark
name: Preisser, John S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: There is increasing recognition of the critical role of intracluster correlations of health behavior outcomes in cluster intervention trials. This study examines the estimation, reporting, and use of intracluster correlations in planning cluster trials. We use an estimating equations approach to estimate the intracluster correlations corresponding to the multiple-time-point nested cross-sectional design. Sample size formulae incorporating 2 types of intracluster correlations are examined for the purpose of planning future trials. The traditional intracluster correlation is the correlation among individuals within the same community at a specific time point. A second type is the correlation among individuals within the same community at different time points. For a “time × condition” analysis of a pretest–posttest nested cross-sectional trial design, we show that statistical power considerations based upon a posttest-only design generally are not an adequate substitute for sample size calculations that incorporate both types of intracluster correlations. Estimation, reporting, and use of intracluster correlations are illustrated for several dichotomous measures related to underage drinking collected as part of a large nonrandomized trial to enforce underage drinking laws in the United States from 1998 to 2004.
Parallel Computation of Piecewise Linear Morse-Smale Segmentations
Creators: name: Maack, Robin G. C.
name: Lukasczyk, Jonas
name: Tierny, Julien
name: Hagen, Hans
name: Maciejewski, Ross
name: Garth, Christoph
Publisher: name: arXiv
Year: 2023
Subjects: subject: Graphics (cs.GR)
subject: FOS: Computer and information sciences

description: This paper presents a well-scaling parallel algorithm for the computation of Morse-Smale (MS) segmentations, including the region separators and region boundaries. The segmentation of the domain into ascending and descending manifolds, solely defined on the vertices, improves the computational time using path compression and fully segments the border region. Region boundaries and region separators are generated using a multi-label marching tetrahedra algorithm. This enables a fast and simple solution to find optimal parameter settings in preliminary exploration steps by generating an MS complex preview. It also poses a rapid option to generate a fast visual representation of the region geometries for immediate utilization. Two experiments demonstrate the performance of our approach with speedups of over an order of magnitude in comparison to two publicly available implementations. The example section shows the similarity to the MS complex, the useability of the approach, and the benefits of this method with respect to the presented datasets. We provide our implementation with the paper.
description: Journal: IEEE Transactions on Visualization and Computer Graphics / Submitted: 22-Jun-2022 / Accepted: 13-Mar-2023
A systematic assessment of normalization approaches for the Infinium 450K methylation platform
Creators: name: Joubert, Bonnie R.
name: Kuan, Pei Fen
name: Peddada, Shyamal D.
name: Nystad, Wenche
name: London, Stephanie J.
name: Wu, Michael C.
name: Håberg, Siri E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The Illumina Infinium HumanMethylation450 BeadChip has emerged as one of the most popular platforms for genome wide profiling of DNA methylation. While the technology is wide-spread, systematic technical biases are believed to be present in the data. For example, this array incorporates two different chemical assays, i.e., Type I and Type II probes, which exhibit different technical characteristics and potentially complicate the computational and statistical analysis. Several normalization methods have been introduced recently to adjust for possible biases. However, there is considerable debate within the field on which normalization procedure should be used and indeed whether normalization is even necessary. Yet despite the importance of the question, there has been little comprehensive comparison of normalization methods. We sought to systematically compare several popular normalization approaches using the Norwegian Mother and Child Cohort Study (MoBa) methylation data set and the technical replicates analyzed with it as a case study. We assessed both the reproducibility between technical replicates following normalization and the effect of normalization on association analysis. Results indicate that the raw data are already highly reproducible, some normalization approaches can slightly improve reproducibility, but other normalization approaches may introduce more variability into the data. Results also suggest that differences in association analysis after applying different normalizations are not large when the signal is strong, but when the signal is more modest, different normalizations can yield very different numbers of findings that meet a weaker statistical significance threshold. Overall, our work provides useful, objective assessment of the effectiveness of key normalization methods.
[Pdf/ePub] The Grimrose Girls by Laura Pohl download ebook
Creators: name: Baker
Publisher: name: Zenodo
Year: 2024

description: The Grimrose Girls by Laura Pohl

 

 

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The Grimrose Girls

Laura Pohl

Page: 400

Format: pdf, ePub, mobi, fb2

ISBN: 9781728228877

Publisher: Sourcebooks

 

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