cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Owning China: the material life of London tradesmen 1700-1750
Creators: name: Hsiao, Chihyin
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: Chinese ceramics, eighteenth-century London, material culture.

description: This PhD project seeks to understand how chinaware was used and appreciated in London tradesmen’s homes between 1700 and 1750. Statistical evidence from London Court of Orphan Inventories reveals the consumption of key household items in London tradesmen’s homes. Chinaware, a synonym for Chinese porcelain, was one such commodity which enjoyed a surging popularity during the first half of the eighteenth century. Records show that the ownership of Chinese porcelain fluctuated amongst London tradesmen’s households, indicating potential competition between chinaware, silver, pewter and delftware. This thesis thus argues that local metal and ceramic productions could no longer support the lifestyle required for polite living in eighteenth-century England while chinaware successfully established itself as a luxurious item for tea and dinner services. The change of household fashion not only highlights the increasing number of emerging consumers but also celebrates their desire to upgrade their material life. The dynamic cultural imaginary of exotic goods gave emerging consumers an opportunity to purchase a new social identity which had not been available in the previous century. Ultimately, the want for a better material life changed the hierarchy of things at home and the social behaviour of people. Gender representation, family alliance and business partnership are exemplified through surviving ceramic objects.
The optics of anatomy and light: a studio-based investigation of the construction of anatomical images
Creators: name: Sellars, Nina Victoria
Publisher: name: Monash University
Year: 2019
Subjects: Uncategorized

description: As anatomical images of the human body increasingly circulate in the current visual and media culture, they belong not only within the domain of scientific enquiry but also exist in a creative field that helps to further define our human identity. Images that expose the inner materiality of the body are becoming naturalized in our everyday lives, as a result of the increased proliferation of medical imagery in various media. The context for this research project is provided by a contemporary investment in what we may term ‘the anatomical gaze’; one that reaches beyond the strictly defined discipline of anatomy. However, this work considers anatomical images at their inception to explore the role light plays in defining the anatomical gaze. Here, light is presented as an instigator rather than a passive illuminator of anatomical knowledge. The studio-based investigation poetically engages with some of the ways in which light impacts upon our negotiations and clarifies our imaginings of the human anatomical body. It also discusses how these experiences are articulated through images. The visual part of the research is comprised of a series of installations that hybridize old and new optical technologies, in ways that expose slippages and meeting points between different ways of visualizing anatomy. The magnification of sight and intensification of light enabled by various technological advancements have allowed us to see what previously remained invisible in the anatomical body. But, more importantly, these technical developments have also provided us with some new ways of conceptualizing these recently discovered bodily structures and their representations. For this reason anatomy is positioned in this research project as a topic that should not be, and in reality cannot be, insulated from cultural concerns. Indeed, anatomy underpins Western ideas of the body, identity and subjectivity, and it is important that it should remain open to critical investigation.
Effect of semiconductor laser noise on coherent optical OFDM systems
Creators: name: Al-Aubaidy, Zaid
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Orthogonal frequency division multiplexing (OFDM) is a modulation/multiplexing method that has many advantageous when it is employed in optical fiber communications. However, the OFDM signal is very sensitive to semiconductor laser’s phase noise that requires either to use a very stable semiconductor laser with a narrow linewidth, or to equalize the phase noise effect before or after demodulation. This thesis presents an in-depth analysis of the long-haul coherent optical OFDM (CO-OFDM) link with pilot-aided feedforward loop (PA-FFL), which is used for pre-demodulation phase noise compensation. The thesis examines effect of large semiconductor laser noise on the OFDM’s performance yielding a new homodyne OFDM design, and showing the feasibility of this technique comparing with the conventional coherent OFDM system.
Patenting activity and financial performance at the Malaysian firm level: an empirical study (1994 – 2008)
Creators: name: Abdol Ghapar, Farha
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: While patenting activity is common in advanced economies, this is not the case in emerging economies. However, there is reason to be optimistic that patenting activity benefits an emerging economy such as Malaysia. This study analyzes the relationship between the patenting activity and financial performance at the Malaysian firm level for firms that have been granted patents in Malaysia and the United States of America. While previous empirical studies adopted the market valuation model, we use the profit maximization model as our theoretical underpinning for this study. Hence, the financial performance variables are measured based on the accounting information – the sales, profits and profit margin. While previous empirical studies measured the patenting activity from an invention based on a simple patent count, we measure from within the patent system. Hence the patenting activity variables are measured based on the patent renewal/ application and quality measures. The sample study has also been divided into manufacturing firms and technology fields – human necessities/ performing operations and mechanicals/ electronics. We applied a panel dataset from 1994 to 2008 and the model is estimated using panel least square, fixed effects model, random effects model and generalized method of moments with various types of effects specifications and transformations. The key finding from the hypotheses testing is that there is a significant relationship between patenting activity and financial performance at the Malaysian firm level, but that the impact is rather small and the signs are mixed. This situation may due to the competitive condition that the firms faced, even though patenting is well known for its monopoly power.
title: Structural and biochemical characterisation of p14ARF – E3 ubiquitin ligase complexes
Creators: name: Kowalczyk, Dominika
Publisher: name: University of Glasgow
Year: 2019

description: Post-translational modifications are a common mechanism in defining proteins role, fate and engagement in different intracellular processes. One of such modifications is ubiquitination – attachment of a small ubiquitin polypeptide to the target’s lysine residue. This process involves a complex enzymatic cascade, consisting of three enzymes – E1, E2 and E3. As a result, ubiquitin is activated, conjugated and ligated to the target in a well-controlled but poorly understood manner. Ubiquitination can designate proteins for proteasomal degradation, endocytosis or alter their interaction with other partners. Any disorganisation and misregulation of that process can lead to severe disruption of cellular processes, resulting in the development of serious diseases, such as cancer or neurodegenerative disorders. MDM2 is a RING-E3 ubiquitin ligase, mainly known for its ability to ubiquitinate tumour suppressor p53 and is overexpressed in different types of cancer. MDM2 can act either as a homodimer or a heterodimer, when it’s bound with its homolog – MDM4. Interestingly, despite the high sequence homology, the two proteins behave differently, depending on the dimerisation state. HUWE1 is a HECT-E3 ubiquitin ligase, which has been shown to influence the activity of a range of pro- and anti-apoptotic proteins, such as p53, MCL1 and c-MYC. Both MDM2 and HUWE1 have been reported to be inhibited by p14ARF protein, which has a prominent effect on cell survival and homeostasis. This thesis presents my work on deciphering how p14ARF influences the activity of MDM2 and HUWE1. I have focused my work on recombinant proteins grown in bacterial expression system, which were further analysed with an implementation of a range of biochemical and structural techniques. Defining an exact mechanism of p14ARF-driven inhibition of MDM2 and HUWE1 could provide long awaited knowledge, relevant for the design of new anti-cancer therapeutics.
Additional file 7: of Spatiotemporal patterns and environmental drivers of human echinococcoses over a twenty-year period in Ningxia Hui Autonomous Region, China
Creators: name: Cadavid Restrepo, Angela
name: Yang, Yu
name: McManus, Donald
name: Gray, Darren
name: Barnes, Tamsin
name: Williams, Gail
name: Soares MagalhĂŁes, Ricardo
name: Hamm, Nicholas
name: Clements, Archie
Publisher: name: figshare
Year: 2018
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Astronomical and Space Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Number of observed and expected number of CE cases by year (1994â 2013) in NHAR for the period 1 January 1994 to 31 December 2013. (DOCX 78 kb)
title: A study of using REITs as an alternative way of financing affordable housing in Chinese major cities, based on the context of Nanjing
Creators: name: Huang, Jie
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: Affordable housing, REITs, China.

description: This thesis examines the possibility of establishing an affordable housing Real Estate Investment Trust (REIT) in major Chinese cities in order to address the financial problem faced by the country’s affordable housing sector. This thesis builds, for the first time, a robust link between the affordable housing sector and REITs in China based on real world scenarios. The link is supported by real data from the affordable housing sector of Nanjing, as well as well-established international practices from Hong Kong and the United States. In order to establish the link between the affordable housing sector and REITs in China, this thesis uses qualitative methods to address three guiding questions: 1) how affordable housing is financed in Nanjing, what the current problems are in this financing system, and why REITs might be useful; 2) if REITs are useful and necessary in China, what insights can be learned from overseas affordable housing REITs and 3) how an affordable housing REIT can be established in Nanjing based on the Hong Kong and US models and experiences, and what barriers currently exist that prevent Chinese REITs from being created in the affordable housing sector. This thesis finds that current affordable housing finance in China heavily relies on government borrowings, and public rental housing serves as a source of governmental financial burden as this form of housing cannot be sold to repay the debt. Thus, the Chinese government has considered the vehicle of REITs as the best option to liquidate the existing stock and free resources to fund further investment and repay the debt. In addition, overseas insights suggest that the Hong Kong model could provide the strategic framework, while the US model can provide specific tactics to be adopted in the proposed Chinese REIT in order to avoid some of the difficulties experienced in Hong Kong. This thesis ultimately suggests that a purely affordable housing REIT (containing housing only) would be impossible to establish in Nanjing, or in similar major cities, under current conditions. However, an REIT holding commercial real estate within affordable housing estates would be a workable solution to the affordable housing sector, although it would face barriers of law, taxation and a lack of skilled workers.
Functional characterisation of the drosophila protein tyrosine phosphatase dPTP61F
Creators: name: Buszard, Bree Jamie
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: The insulin signalling pathway serves an important role in many biological processes, including the maintenance of glucose homeostasis, protein synthesis, cell growth, and proliferation. The negative regulation of insulin signalling is mediated to a large extent by protein tyrosine phosphatases, including the homologous proteins T cell protein tyrosine phosphatase (TCPTP) and protein tyrosine phosphatase-1B (PTP1B). As deregulation of insulin signalling is involved in the pathogenesis of many diseases, in particular type 2 diabetes, it is important to improve understanding of the regulation of insulin signalling by PTP1B and TCPTP. To this end, the function of the Drosophila melanogaster homolog of PTP1B and TCPTP, dPTP61F, is studied. This thesis describes the characterisation of dPTP61F in the regulation of Drosophila insulin signalling. Using RNA interference against dPTP61F in S2 cells it was demonstrated that dPTP61F is a negative regulator of InR phosphorylation in vitro. Co-overexpression experiments with the Drosophila InR confirmed that dPTP61F is capable of negatively regulating insulin signalling in vivo. Furthermore, an association of dPTP61F with the adaptor protein Dock was shown to improve the efficiency of dPTP61F-mediated InR dephosphorylation. The involvement of dPTP61F in the regulation of insulin signalling may influence growth as overexpression of dPTP61F reduces both cell size and proliferation. Imprecise P-element excision was undertaken to generate a loss-of-function allele of dPTP61F. A partial mutant allele lacking two of four dPTP61F isoforms was generated and displays phenotypes including decreased median lifespan and reduced female fecundity, identifying novel roles of dPTP61F. Increased apoptosis and a reduction in the number of vitellogenic egg chambers is a likely cause of the reduced fecundity. This thesis investigated the involvement of several biological pathways, including insulin signalling, in mediating the decrease in fecundity. This thesis also examined whether human PTP1B and TCPTP can function in Drosophila. Misexpression studies confirmed that PTP1B and TCPTP can negatively regulate Drosophila insulin signalling. In addition, the nuclear localised isoform of TCPTP, TC45, can rescue the fecundity defect of the dPTP61F partial loss-of-function mutant. These studies describe the role of dPTP61F in the regulation of insulin signalling and additional biological processes and give insight into the importance of subcellular localisation in mediating substrate specificity and selectivity of PTPs.
Additional file 8: of Spatiotemporal patterns and environmental drivers of human echinococcoses over a twenty-year period in Ningxia Hui Autonomous Region, China
Creators: name: Cadavid Restrepo, Angela
name: Yang, Yu
name: McManus, Donald
name: Gray, Darren
name: Barnes, Tamsin
name: Williams, Gail
name: Soares MagalhĂŁes, Ricardo
name: Hamm, Nicholas
name: Clements, Archie
Publisher: name: figshare
Year: 2018
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Astronomical and Space Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Number of observed and expected number of AE cases by year (1994â 2013) in NHAR for the period 1 January 1994 to 31 December 2013. (DOCX 72 kb)
title: 03_0232
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Additional file 9: of Spatiotemporal patterns and environmental drivers of human echinococcoses over a twenty-year period in Ningxia Hui Autonomous Region, China
Creators: name: Cadavid Restrepo, Angela
name: Yang, Yu
name: McManus, Donald
name: Gray, Darren
name: Barnes, Tamsin
name: Williams, Gail
name: Soares MagalhĂŁes, Ricardo
name: Hamm, Nicholas
name: Clements, Archie
Publisher: name: figshare
Year: 2018
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Astronomical and Space Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Annual temperature in NHAR for the period 1 January 1980 to 31 December 2013 and number of cases of CE and AE for the period 1 January 1994 to 31 December 2013. (DOCX 98 kb)
¡El asombro es el principio de la sabiduría! - Sócrates - Albert Einstein, Carl Sagan, así como el teólogo Abraham Heschel, San Gregorio de Nisa y el poeta y teólogo irlandés John O'Donohue, y un prefacio con la "belleza" de Kant como génesis de la moral + la "belleza de la voluntad" filipina para comparar.
Creators: name: Peck Jr, Charles E
Publisher: name: Knowledge Commons
Year: 2025
Subjects: subject: Royal Institute of Philosophy
subject: International Association for Philosophy of Law and Social Philosophy
subject: Philosophy of Science Association
subject: British Society for the Philosophy of Science
subject: Truth Consciousness, Inc. (USA)
subject: Society for the Anthropology of Consciousness (U.S.)
subject: Consciousness--Research
subject: Consciousness--Social aspects
subject: Seven pillars of wisdom (Lawrence, T. E.)
subject: Wisdom--Biblical teaching
subject: Wisdom (Gnosticism)
subject: Socrates
subject: Irish studies
subject: Irish literature--Middle Irish
subject: Irish--Religion
subject: Einstein, Albert, 1879-1955
subject: Saint Gregory's University
subject: Spirituality in art
subject: Spirituality--Social aspects
subject: Spirituality--Psychology

description: Sócrates observó que "¡El asombro es el principio de la sabiduría!" - "Donde la imaginación está viva, el asombro está completamente vivo. Cuando la imaginación está viva, la posibilidad despierta porque la imaginación es la gran amiga de la posibilidad. Las posibilidades siempre son más interesantes que los hechos. No deberíamos desaprobar los hechos, pero nuestro mundo está repleto de ellos". John O'Donohue
Hace dos mil años, Aristóteles destacó el afán de comprensión y conocimiento cuando afirmó: "¡Todos los hombres desean conocimiento!" - el deseo de significado impulsado por un profundo sentido de asombro y maravilla por el "Todo", el mundo y el universo. El argumento tácito de Sócrates es que el asombro, la curiosidad y la imaginación están íntimamente conectados con la sabiduría. Einstein observó que la imaginación fue absolutamente crucial para todos sus descubrimientos.
title: Essays in bank dividend signaling, smoothing and risk shifting under information asymmetry and agency conflict
Creators: name: Patra, Sudip
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: dividend signalling, dividend smoothing, risk shifting, partial adjustment model, GMM, LOGIT, TOBIT.

description: The current thesis is a collection of essays on costly signaling, smoothing (partial adjustment), and risk shifting through various pay outs by bank holding firms. The thesis is based on three chapters, or sections, which are through econometric investigations on the above mentioned topics. The major findings of the investigations are, one, a detailed firm level information content analysis of costly signaling by banks via different pay out methods, two, that partial adjustment or smoothing via pay outs can also be perceived as costly signals which is based on the information content of allied measures like bank specific speed of adjustments, and half-life periods, three, that rather than dividend pay outs share repurchases play relatively significant role in risk shifting exhibited by banking firms. Chapter 1 is devoted to the analysis of different types of dividend and other pay out signaling under information asymmetry (between the outsider shareholders of banks and the insider managers), and impact of various bank specific variables on the levels of pay outs/ signaling, thus revealing the information content of such signaling. Both panel data analysis and vector auto regression analysis have been conducted to achieve these findings. Another finding in this section is a comparative analysis between share repurchases and dividend pay outs by bank holding firms. Chapter2 is devoted to the investigation of bank specific partial adjustments of dividends, a modified partial adjustment model is used which is capable of investigating bank specific speeds of adjustments and half-life periods which may vary over periods. Such a model is an improvement over basic smoothing models in the standard literature which have mainly investigated the industry average speed of adjustment, and hence less efficient in investigating the bank specific information content of such measures. Chapter 3 provides analysis based on a system of equations model on, one, whether risk shifting has been exhibited by the bank holding firms for a comprehensive period between 1990-2015, and two, which are the specific pay out channels through which such risk shifting or wealth transfers have taken place.
A studio research project: Malay celebration as a cultural expression in creating sculpture utilizing an up-cycle approach.
Creators: name: Khairi, Hanif Bin
Publisher: name: Monash University
Year: 2019
Subjects: Uncategorized

description: The basis of this thesis is to examine particular Malay cultural objects that are used in celebratory ceremonies as a foundation to advance studio research. Specifically, the Malay wedding ceremony is embraced because of its cultural significance – providing meaning and insights into a society; a country of my origins. In this context, the aim of this research study is to signify and to promote cultural expression and exchange through the creation of sculptural objects. This research also questions why and how sustainable-related art practices can be incorporated to produce sustainable and meaningful art-forms in the studio and discusses such implications and impacts as a result. In conducting this research, a practice-based research methodology has been implemented. As this research deals about sustainable art that are pertinent with up-cycling discarded materials, I began the creative process with collecting discarded household and industrial objects. From these materials, I created several series of sculptures and wall installations that illustrate the harmonious factor of up-cycle, materials, culture and nature. An up-cycle approach is used in order to transform those mundane objects into a new value and characteristics form of sculptures. This research paper also attempts to highlight the work of a number of contemporary visual artists who have been chosen for examination because of issues or subjects that have been brought up, the choice of materials, and their approaches or methods in creating artworks. Their approaches vary from one another, but the common thread that informs and confronts my research project is to address the idea of sustainability, signifying cultural expressions, materiality, as well as to emphasise the use of elements and principals of art in creating sculpture such as colour, texture, material, shape and form. Primarily, almost all the art objects that I have created used lamination and compression techniques, as well as employing the concept of `addition and subtraction’ – a sculptural term associated with adding and removing materials during the process of making to the desired form. The studio-based research consists of two sections: Part One contains the written exegesis, while Part Two contains original work exemplifying and locating the ideas developed in conjunction with the written exegesis.
Modular stereo vision - theory, implementation, and application
Creators: name: Ng, Oon-Ee
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Just like the biological eye, human visual depth perception is extremely complex. Part of this complexity is that it is multi-modal. One of the primary modes is that of stereo vision. Computational stereo vision aims to replicate this mode of depth perception. The research in this thesis is focused on improving computational stereo vision. The stereo vision problem is primarily a search/matching problem. Many stereo vision algorithms have been proposed to solve the stereo matching problem. Several paradigms are available to make sense of and differentiate between these algorithms. This thesis considers the relative merits and utility of the current paradigms. The component analysis paradigm is selected as being best suited to both classify and improve on current stereo vision algorithms. The Modular Stereo Vision Model (MSVM) is presented. This model is based on the component analysis paradigm. The MSVM provides a single set of classification rules which enables accurate segmentation of current and future stereo vision algorithms. A programmatic implementation of the MSVM, called Anystereo, is also presented. Anystereo is a complete system which allows arbitrary stereo vision methods to be combined to form an entire stereo vision algorithm. The Anystereo system is used to implement three novel stereo vision methods. The Intrinsic Images method deals with illumination variation between the images of the input stereo pair. This method is based on identifying and isolating the intrinsic components of the input images which do not depend on illumination. The results of applying this method in the presence of illumination variation are presented. The Quartile Matching method deals with exposure variation between the images of the input stereo pair. This method is based on the observation that the relative ordering of intensities does not change when exposure varies. A non-parametric ranking is used to measure matching cost between the input images. The results of applying this method in the presence of exposure variation are presented. The Connected Component Aggregation method deals with the boundary problem. The boundary problem arises at disparity boundaries when one surface is more highly textured than the other surface. This method aggregates over disparity-slices rather than over the pixels of the input images to prevent aggregation from crossing disparity boundaries. The results of applying this method are presented. The work presented here is targeted at improving the stereo vision field of research. This is accomplished practically through various stereo vision methods and philosophically by the introduction of the MSVM and the Anystereo system.
title: Molecular construction of sulfonamide oligonucleotides
Creators: name: Korotkovs, Valerijs
Publisher: name: University of Glasgow
Year: 2019

description: Antisense oligonucleotides (ASO's) are a class of therapeutics that target RNA. Advancements in chemical modifications of oligonucleotides culminated in recent FDA approvals of three ASO's for the treatment of homozygous familial hypercholesterolemia (Kynamro), Duchenne muscular dystrophy (Eteplirsen), and spinal muscular atrophy (Spinraza). In this work, efforts towards an efficient and scalable synthesis of sulfonamide oligonucleotide monomers were developed for replacement of the phosphodiester linker of RNA by a sulfonamide-containing linker to allow construction of sulfonamide oligonucleotides. The synthesis of monomers is described through Chapters 2 to 4. Using the described monomers, it was possible to synthesise sulfonamide oligonucleotides in solution phase and some crucial properties of the resulting oligonucleotides like cell permeability were studied in Chapter 5.A sulfonamide-phosphodiester oligonucleotide chimera (SaDNA) was prepared by synthesising a sulfonamide Thymine-Thymine dimer compatible with phosphoramidite chemistry and incorporating it into a DNA sequence in Chapter 6. The resulting SaDNA was used in a thermal stability experiment to study SaRNA double-strand complexes with DNA and RNA. Although sulfonamide modification caused a decrease in melting temperature (Tm) the incorporated sulfonamide monomer displayed selectivity in binding to RNA. A preliminary experiment was performed using the prepared sulfonamide monomers to synthesise oligonucleotides on solid phase using a Rink amide-polystyrene resin in Chapter 7.
title: The discovery of phage-inducible chromosomal islands (PICIs) in Gram-negative bacteria
Creators: name: Fillol Salom, Alfred
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: SaPIs, PICIs, MGEs, HGT, cos, lambda.

description: Staphylococcus aureus pathogenicity islands (SaPIs) are highly mobile phage satellites that are intimately related to certain helper phages, whose life cycle they parasitise for their transfer to another bacterial hosts. As they encode virulence and fitness factors, this dissemination contributes to bacterial evolution, host adaptation and pathogenesis. During the last two decades, the relationship between SaPIs and helper phages has been studied, being the SaPIs one of the best characterised phage satellites. Recently, SaPI-like elements have been characterised in other Gram-positive species, constituting a new family of mobile genetic elements (MGEs): the phage inducible chromosomal islands (PICIs). PICIs are defined by the following features: exclusive attachment sites, unique genetic organisation, exclusive PICI genes, unique replicon, helper phage dependant induction and convergent mechanisms of phage interference. Based on the high prevalence of PICIs in Gram-positive bacteria, the presence of these MGEs in Gram-negative bacteria was studied. This study expands the PICI family to englobe, for the first time, members of Gram-negative bacteria. Using Escherichia coli and Pasteurella multocida as models, PICI elements present in these bacteria were characterised. During this study, a convergent mechanism of interference was perceived, the production of PICI-sized capsids. Furthermore, the prototypicle E. coli PICI, EcCICFT073, was identified as a cos PICI. This result, along with the recently characterised cos SaPIs, represents a paradigm shift involving cos phage in gene transfer. Additionally, a novel example of molecular parasitism was established, by which cos PICI elements encode a protein with a dual role, to block phage reproduction and to redirect phage packaging to promote their own transfer. Indeed, this is a one-shot strategy, highlighting PICIs as one of the most sophisticated parasites in nature. Overall, these results highlight the pervasive presence of PICI elements in Gram-negative bacteria, deciphering different strategies employed by these elements to achieve promiscuity in nature.
title: Results of a Colony Feeding Test to Evaluate the Efficacy of Vadescana for Control of Varroa Mites in Honeybees (Apis mellifera L.)
Creators: name: Portail, Béatrice
name: Knaebe, Silvio
name: Bargen, Holger
name: Janke, Martina
name: Manley, Brian
Publisher: name: Bundesbehörden und Einrichtungen im Geschäftsbereich des Bundesministeriums für Ernährung und Landwirtschaft (BMEL)
Year: 2025
Subjects: subject: 630

description: Julius-Kühn-Archiv, vol. 481Hazards of pesticides to bees, 16th International Symposium of the ICP-PR Bee Protection Group, - Proceedings -; 15th - 17th October, 2024; Sevilla (Spain), p. 34
Environmental education in a climate of reform: understanding teacher educators’ experiences
Creators: name: Almeida, Sylvia Christine
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: In a climate of national and international policy reform in environmental education this study is designed to examine the ways in which environmental education is implemented by teacher educators (n=11) in a particular teacher education institution in India. The rapid economic progression particularly over the last decade has led to environmental problems of an unprecedented level. India has struggled to keep pace with these problems resulting in the judiciary stepping in and ordering mandatory Environmental Education in the curricula for all schools and undergraduate programs. This study shows that while there has been development of policies, their impact on teacher educators’ practice, and therefore student teachers’ learning about Environmental Education is limited. This thesis is an ethnographic study of a Teacher Education institution in India. The data included public and private policy documents, semi-structured interviews and classroom observations. These data sets helped to shed light on the work and lives of the participating teacher educators and how they understood, negotiated, determined and implemented Environmental Education. The study showed that while these teacher educators had a clear understanding of the environment and saw the need/importance of incorporating Environmental Education in their daily practices they had very little scope to do so. There were numerous factors that constrained implementation. This thesis argues that while policy reforms are a step in the right direction they need to be backed up with strong implementation systems in order to be successful.
title: Homeland variations: a response to the anxieties of self-identification in the context of displacement
Creators: name: Maslowska, Agata
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: Exophony, language, identity, displacement, migration.

description: My PhD thesis addresses the question of how multilingual and exophonic writers used ‘other’ languages to express distinct cultural and identity concerns. I argue that writers have used languages in their fiction to negotiate the new voice of a migrant/minority community with the dominant culture and to challenge the mainstream reader to find new ways of reading the migrant/minority experience. In the critical thesis I explore such themes as writing in exile, narrative fugues, rhizomatic writing as they weave into my writing poetics. I use the concepts of a musical fugue and a rhizome to explore the politics of identity and language in the context of migration and displacement. These concepts offer a new way of reading the migrant experience by reframing it as the polyphony of multiplicity rather than the monophony of difference. Through my essayistic exploration, the critical thesis becomes a commentary on the novel and my manifesto as an exophonic writer who has chosen English rather than Polish as the main literary language. I have used the results of my research to write Homeland Variations, a novel merging the interweaving stories of various migrants (Jan, Janine, her parents, Małgosia, Uncle Jurek, Maria, and Sophie in Amsterdam) into one fugal narrative and exploring the questions of language, identity, and place. The novel consists of two parts: Jan’s and Janine’s stories which stand in a counterpoint relation to each other and exist independently, just like two melodies in a fugue, connected through themes, languages, a character Maria, and a place – Edinburgh where both stories end. The two stories stand independently also with regards to the narrative style, as Jan’s narrative is surrealist, while Janine’s is realist. Homeland Variations portrays the loss of the mother tongue, the loss of social environment, and all the connections that make us feel that we belong. Through the voices of migrating characters, it looks at interactions within linguistic landscapes, at the distance and separation from everything anyone who lives ‘in exile’ desires to call home. In the novel I merge languages on the page to show the multiple, centri-fugal, rhizomatic nature of being a migrant and writing in a foreign language. My creative vision goes against the monolithic “one nation-one state-one language” approach to both writing and migration. Both the critical thesis and the novel are my attempts to find language to talk about language in the acceptance of our state of being unsettled.
The aftermath of provocation: homicide law reform in Victoria, New South Wales and England.
Creators: name: Fitz-Gibbon, Kate Esther
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Over the past decade, homicide law reform surrounding the partial defences to murder has animated debate among criminological scholars and legal stakeholders in Australia and the United Kingdom. In response to these debates, criminal jurisdictions have conducted reviews of the partial defences to murder and implemented reforms targeted at reducing gender bias in the law which has played out through the operation of the partial defence of provocation. This research examines the different approaches taken to addressing the problem posed by provocation in Victoria, New South Wales and England. In doing so, it explores questions around the need for reform to the law of homicide, the effects of these reforms in practice, and the influential role of sentencing in questions surrounding homicide law reform. Throughout the analysis key frameworks of criminological thought in relation to feminist engagements with the law, the conceptualisation of denial and the influence of law and order politics upon the development of criminal justice policy are applied. By drawing on 81 in-depth interviews conducted with legal stakeholders across the three jurisdictions under study, and an analysis of relevant case law, this research concludes that reforms implemented to counter gender bias in the operation of homicide law have produced mixed results in practice, particularly in connection to the law’s response to three key categories of person in the courtroom: the jealous man, the female victim of homicide, and the battered woman.
title: Elucidating the role of mTOR kinase in chronic lymphocytic leukaemia cell migration
Creators: name: Holroyd, Ailsa
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: chronic lymphocytic leukaemia, AZD8055, rapamycin, mTOR kinase inhibition, B cell receptor signalling, chemokine signalling, lymphocyte migration.

description: Chronic lymphocytic leukaemia is a mature B cell neoplasm which, despite recent focused research attention, remains incurable. It is the commonest leukaemia in the Western world and affects around 3,500 patients per annum in the UK and with the median age of those diagnosed at around 70 years it poses a specific challenge in disease management with standard chemoimmunotherapy being potentially too toxic for many patients. Treatments targeting the B cell receptor (BCR)-mediated signals including ibrutinib and idelalisib which target BTK and PI3K respectively, have pronounced clinical effects with improvement in progression-free and overall survival for significant patient numbers and are becoming more widely available. However, issues of disease resistance mutations and clonal evolution leave scope for novel targets of BCR and related signalling pathways. My hypothesis is that the serine/threonine protein kinase mechanistic target of rapamycin (mTOR) signalling which is located downstream of BTK and PI3K and downstream of BCR signalling offers a promising therapeutic target in CLL and may complement existing therapies that have proven clinical efficacy. Furthermore, dual mTORC1/2 inhibition offers a potential mechanism for overcoming the negative feedback loop which internally regulates mTOR kinase thus may offer potential for an improvement on the mTORC1 inhibitors already tested in clinical trial.
The synthesis method and sequence of the peptide used in this study from Investigation of the antibiofilm capacity of peptide-modified stainless steel
Creators: name: Cao, Pan
name: Li, Wen-Wu
name: R. Morris, Andrew
name: Horrocks, Paul D.
name: Yuan, Cheng-Qing
name: Yang, Ying
Publisher: name: The Royal Society
Year: 2018

description: Figure 2 The sequence and spatial structure of peptide 2 (P2). The sequence of the peptide is ACTFFAFFFYLPFTCFT (disulfide 2-15) with purity of 95%.
An archaeobotanical analysis of Late Palaeolithic, Peiligang and Yangshao sites in Henan and Shanxi Provinces, North China
Creators: name: Bestel, Sheahan Velma Margaret
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: This thesis examines plant based subsistence across the ‘agricultural transition’ in North China. The study was based around the Middle Yellow River region and included the Yiluo Basin in Henan Province, other sites in Henan and the Late Palaeolithic site of Shizitan in Shanxi Province. The study time period covered from c. 20,000 cal BP until the end of the Yangshao period c. 5,000 cal BP, with a focus on the transition period between c.13,800 cal BP – 5,000 cal BP. Plant remains examined included charred macrobotanical remains from the Late Palaeolithic, Peiligang and Yangshao periods. Microfossil remains from Peiligang artefacts included both starch and phytolith residues from grinding implements and denticulate stone sickles. The first macrobotanical evidence for the use of millet tribe grasses in North China was presented, with these occurring at the Shizitan site during the Late Palaeolithic period. Millet tribe grasses were subsequently domesticated during the Peiligang period and occur in the study region in the form of small numbers of foxtail and broomcorn millet grains. Domesticated cereal seeds accounted for less than 30 percent of seed taxa in the Peiligang period and less than 12 percent of seed taxa in the Yangshao period. During the Late Palaeolithic and Peiligang periods evidence for experimentation with other grasses was present in the form of panicoid and pooid (cf. Triticeae) starch remains on grinding implements. Residues recovered from Peiligang grinding implements suggest that acorns were an important aspect of subsistence. Macrobotanical evidence for acorns is recorded in the study region at sites such as Jiahu. Macrobotanical evidence for acorns was not present at Tieshenggou, where many of the analysed grinding implements were recovered. In addition to both Lithocarpus sp. and Quercus sp. acorns, Peiligang grinding implements preserved underground storage organ starch from the Cucurbitaceae or Dioscoreaceae families. Starch similar to that from the Phaseoloeae tribe of the bean family was also recovered. Denticulate stone sickles preserved evidence of both grass and eudicotyledonous residues from both the Shigu site and the Jiahu site. These residues do not rule out the possibility that these sickles were used to harvest grasses including millets (Shigu) and rice (Jiahu) but further evidence is needed to support this. The agricultural transition occurred later than expected in the study region, with domesticated cereals only accounting for a small proportion of seed-based subsistence in both the Peiligang and Yangshao periods. This is consistent with ‘middle ground’ subsistence (Smith, B. D., 2001) located between the two extremes of agriculture and hunting-gathering communities on a food production continuum scale.
title: Surface acoustic waves nebulisation for pulmonary drug delivery
Creators: name: King, Xi
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: Surface acoustic waves, pulmonary drug delivery, liposomes, gene therapy.

description: Surface acoustic waves (SAWs) devices for droplets manipulation have become widespread in the last twenty years for their ability to work at the microscale, focusing their energy on small targets. SAWs, combined with vesicles-based drug carrier systems such as liposomes, offer the opportunity of efficient drug delivery to the lungs. Liposomes are important drug delivery systems due to their structure, able to retain either a hydrophilic drug within their aqueous core, behind a phospholipid barrier, or a hydrophobic drug associated with the membrane's hydrophobic core. They are capable of releasing the drugs in a controlled manner in conjunction with pH or temperature changes, which is a fundamental feature for the treatment of many diseases such as cancer. SAW devices are ideal platforms for liquid manipulation at the micro-scale, due to their low fabrication cost and low power consumption. The main advantage as a nebuliser, for pulmonary drug delivery, lies with their ability to provide control of the aerosolized droplet size. Another advantage, compared to a commercially available nebuliser, is given by the high frequencies (>1MHz) employed during the nebulisation, which avoids denaturation of the delivered molecules by cavitation. The aim of this PhD is the development of a SAW nebulisation device, capable of delivering drug-loaded liposomes in a targeted manner to the deep lung tissues. The creation of a novel SAW nebulisation platform, where liposomes can be formed in-situ and drugs (or complex molecules) can be loaded in one single step, will avoid drugs side effects and wastage of expensive drugs.