cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
PYCASO cruise,Thalia R/V
Creators: name: DREVES Luc
Publisher: name: Sismer
Year: 2000

description: PYCASO (PY pour PenlY, CA pour pays de CAux, SO pour baie de SOmme). Dans le cadre du programme de Surveillance écologique et halieutique du site électronucléaire de Penly (Seine-Maritime), l'étude du domaine benthique fait l'objet d'une prospection biomorphosédimentaire quadriennale depuis 1988 (Penly-1988, SONPEN-1992, PYCAUX-1996). Cette étude doit permettre de mettre en évidence d'éventuelles modifications des fonds sublittoraux aux alentours de la centrale.Les études biomorphosédimentaires subtidales réalisées en 1988 et 1992 ont permis de dresser une image fiable de la morphologie, de la sédimentologie et de la biologie des fonds. L'étude analogue menée en 1996 a permis de préciser l'évolution des fonds observée en 1992, et de mieux cerner la répartition de l'espèce Lanice conchilega. Elle permit également un examen des rejets de dragage effectués devant Dieppe et une prospection vers l'ouest jusqu'au cap d'Ailly. La campagne 2000 comprendra : une couverture morphosédimentaire par sonar latéral et sondeur multifaisceaux de part et d'autre de la centrale (entre Dieppe et Le Tréport) jusqu'à 2 milles nautiques au large ; des échantillons biologique et granulométrique, en des points choisis d'après les résultats des études antérieures et la couverture morphosédimentaire précitée. La campagne 2000 aura, par ailleurs, comme particularité une extension de la couverture morphosédimentaire entre Le Tréport et la Baie de Somme.
Involvement of iron ions in 6-hydroxydopamine-induced disruption of intracellular copper metabolism
Creators: name: Kato, Ami
name: Tani, Ayano
name: Kamijo, Fuka
name: Otsuka, Tomohiro
name: Kamiya, Tetsuro
name: Hara, Hirokazu
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified

description: Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra. Recently, disorders in metabolism of metals, including copper (Cu) and iron (Fe), have been reported to be linked to the pathogenesis of PD. We previously demonstrated that 6-hydoroxydopamine (6-OHDA), a neurotoxin used for the production of PD model animals, decreases Atox1, a Cu chaperone, and ATP7A, a Cu transporter, and disrupts intracellular Cu metabolism in human neuroblastoma SH-SY5Y cells. However, the exact mechanisms remain unclear. Meanwhile, intracellular Fe modulates 6-OHDA-induced cellular responses. In this study, we investigated whether Fe participates in 6-OHDA-induced abnormality in Cu metabolism. 6-OHDA-induced reactive oxygen species (ROS) production and cellular injury were suppressed by Fe chelators, deferoxamine and 2,2′-bipyridyl (BIP). These chelators also restored 6-OHDA-induced degradation of Atox1 and ATP7A proteins and subsequent Cu accumulation, indicating that intracellular Fe is involved in the disruption of Cu homeostasis associated with 6-OHDA. Atox1 has redox-sensitive cysteine (Cys) residues in its Cu-binding site. The Cys residues of Atox1 were oxidized by 6-OHDA, and BIP suppressed their oxidation. Moreover, the replacement of Cys with histidine in the Cu-binding site conferred resistance to 6-OHDA-induced Atox1 degradation. These results suggest that oxidized modification of Atox1 by 6-OHDA is likely to accelerate its degradation. Thus, we conclude that Fe and Cu metabolisms are closely related to each other in the pathogenesis of PD.
PYCAUX cruise,Thalia R/V
Creators: name: DREVES Luc
Publisher: name: Sismer
Year: 1996

description: Objectif contractuel :-Dans le cadre du contrat de surveillance de la centrale électronucléaire de Penly, préciser les éventuelles modifications des fonds sub-littoraux côtiers aux alentours de la zone de Dieppe-Le Tréport, comparativement aux études biomorpho-sédimentaires similaires réalisées en 1988 (Penly) et 1992 (Sonpen).Objectifs scientifiques :-étude de la répartition des annélides polychètes Lamice conchilega.-étude des transits sédimentaires à l'Ouest de Dieppe, et préciser le rôle joué par la Pointe d'Ailly dans le transit côtier.Le projet de rattachement est IGA (Impact de Grands Amenagements).ENGLISH - Study the change of costal sea floor around Dieppe, the distribution of the annelida Lamice conchilega and the sédimentary movement at the West of Dieppe.
title:  Inattentional Blindness in a Simulated Driving Task
Creators: name: Kennedy, Kellie D'Hanis
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 2012

description: The visual attention failure of inattentional blindness (IB) frequently occurs for visual information that is relevant and detectable, regardless of whether the unexpected event is congruent or incongruent within the task context. In the context of driving, an occurrence of IB has been associated with deadly collisions as well as significant property damage. For example, in 2008, drivers traveling the wrong way on clearly marked one-way roads caused 747 fatal traffic crashes. Many of these were directly attributable to inattentional blindness. Previous research focused on IB using secondary tasks such as billboards, signage, or bicyclists. The current study explored IB occurrence with stimuli that were directly relevant and critical to primary task performance. The goal of this research study was to investigate variation of inattentional blindness occurrences for a task-relevant stimulus through the manipulation of cognitive load using traffic density. The experimental task required participants to follow a series of auditory directives in a simulated driving environment to reach a destination. The final directive instructed participants to turn left at an intersection clearly marked with a "no left turn" sign. Although the cognitive load manipulation was not successful, 77.6% (59 of 76) of the total number of participants in this study failed to detect the "no-left turn" road sign. This was a significantly stronger IB effect in comparison to similar prior research. These results suggest the need for further investigation on the role of IB on task relevant stimuli.
Emotion Tracking – Heilung und Wachstum der verletzten Seele
Creators: name: Sulz, Serge K. D.
name: Schreiner, Maria
Publisher: name: EUPEHS Research Centre
Year: 2024
Subjects: subject: Emotion Tracking
subject: Antidot
subject: somatischer Marker
subject: Körpersignale
subject: Metakognition
subject: Theory of Mind
subject: Mentalisierungsfördernde Verhaltenstherapie MVT
subject: Wut-Exposition
subject: Bedürfnisbefriedigung
subject: ideale Eltern
subject: 150

description: Deutsche Übersetzung des Artikels: Sulz, S. K. D., & Schreiner, M. (2024). Emotion Tracking - Healing and Growth of the Wounded Soul. European Psychotherapy: Scientific Journal for Psychotherapeutic Research and Practice, 15, 94-113. Der Original-Artikel hat ein Peer Review erhalten.
description: Die meisten Psychotherapien sind zumindest in der Gesprächsführung viel zu kopflastig und rational. Die optimale Mischung von metakognitiver Reflexion und emotivem Dialog herzustellen, ist wohl ein Kunst. Wir wollen zeigen, dass es um professionelles Therapeutenverhalten geht, das geschult werden kann. Allerdings ist es nicht so leicht erlernbar wie die meisten psychotherapeutischen Interventionen. Zu diesem Zweck haben wir Albert Pessos Microtracking (Pesso 2008a,b, siehe Bachg & Sulz 2022) adaptiert – so dass es immer wieder in kognitiv-behavioralen und psychodynamischen Therapien eingesetzt werden kann. Bei der Mentalisierungsfördernden Verhaltenstherapie MVT ist es eines von sieben Therapiemodulen. So wie vor Jahrzehnten die klientenzentrierte Gesprächsführung von Carl Rogers (19XXX) zuehmend Eingang in die psychotherapeutischen Basiskompetenzen gefunden hat, sollte unseres Erachtens Emotion Tracking zu einer Grundkompetenz jeglicher Psychotherapie werden – neben den verfahrensspezifischen Interventionen.
QIMCouf cruise,Côtes De La Manche R/V
Creators: name: Emmanuel, POIZOT
Publisher: name: Sismer
Year: 2024

description: Cette demande de Mission "QIMCouf" s'inscrit dans le cadre de la thèse "QIMCot" (Quantification et réduction des Incertitudes dans les Modèles d'écoulements côtiers : Application à la presqu'île du Cotentin) de Anju Sebastian (2023-2026 ; direction J. Thiébot et encadrement G. Gregoire ; financement Normandie Université). Notre objectif est d'estimer et de réduire, lorsque cela sera possible, les incertitudes des modèles numériques d'écoulements côtiers. Nous nous focalisons sur le lien entre les incertitudes des données environnementales (les inputs du modèle) et les incertitudes sur les résultats du modèle (prédictions de vitesses de courant et de hauteurs d'eau). Après avoir identifier et estimer les incertitudes sur les données d'entrée (principalement de bathymétrie et de rugosité de fond) du modèle, elles seront testées afin d'identifier d'une part celles qui ont la plus forte influence sur les résultats du modèle et d'autre part celles qui donnent le meilleur accord avec les données terrain (des mesures de vitesses de courant ou de hauteurs d'eau par exemple). La validation s'appuiera sur une comparaison entre les résultats de modèle et les indices de transport sur le fond établis à partir de l'interprétation des données géophysiques (bathymétrie) et sédimentaires (nature des fonds) acquises dans le cadre de la mission "QIMCouf". Enfin, l'estimation des incertitudes sera calculée et une distribution de probabilité des valeurs prédites pourra être établie.
title: Strengthening Forest Landscape Restoration through Understanding Land Use Dynamics: Case Study of Tchamba Prefecture (Togo)
Creators: name: Hounkpati, Kossi
name: Adjonou, Kossi
name: Moluh Njoya, Hamza
name: Hlovor, Atsu K. Dogbeda
name: Kipkulei, Harison Kiplagat
name: Sieber, Stefan
name: Löhr, Katharina
name: Kokou, Kouami
Publisher: name: Humboldt-Universität zu Berlin
Year: 2024
Subjects: subject: Remote sensing
subject: Land use
subject: Land change prediction
subject: Key restoration model
subject: Forest landscape restoration
subject: 550 Geowissenschaften

description: Land use and land cover (LULC) change remains a major concern in many countries. To examine how land is used for increased actions on forest landscape restoration (FLR) issues, this study analyses LULC changes from 1991 to 2022 and predict future patterns for the years 2050 in Tchamba Prefecture, Togo, using remote sensing and the Cellular Automata-Markov modelling technique. Results show that dense forests and gallery forests (18.85%), open forest/woodland (20.17%), and tree and shrub savannah (50.04%) were the predominant classes of the landscape in 1991. However, by 2022, most tree and shrub savannah had been converted to mosaic crop/fallow land (52.27%), open forest/woodland (19.32%), and plantation (7.09%). Thus, between 1991 and 2022, forest area decreased from 89.87% to 48.96%; a 45.52% reduction in coverage. Predictions are that open forest/woodland, tree and shrub savannah will decline, while mosaic crop/fallow land will increase (51.66%). However, slight increases were recorded in plantation (9.43%) and a slight balance in dense forests/gallery forests (16.17%). Consequently, forest area will slightly change between 2022 (48.96%) and 2050 (47.41%). These changes in LULC are associated to socio-economic pressures and political instability in the 1990s. So, the return to stability, the promotion of community forests as a key restoration model, and the valorisation of agroforestry species allows for the stabilisation of dense forests/gallery forests areas and an increase in plantation. Thus, it is therefore for all stakeholders involved in restoration processes to consider this information when planning FLR activities.
Carboxymethylnaringenin: a promising antioxidant in the aqueous physiological environment
Creators: name: Vo, Quan V.
name: Hoa, Nguyen Thi
name: Mechler, Adam
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified

description: The synthetic naringenin derivative (2S)-8-carboxymethylnaringenin (CMN) was developed for the treatment of bacterial and viral respiratory infections. There are indications that CMN may act as an antioxidant, however, no studies have been conducted in this regard. This work is aimed at assessing the antiradical capacity of CMN against various physiologically relevant species in physiological environments by using thermodynamic and kinetic calculations. According to the results, CMN only exhibits modest HOO• antiradical activity in lipid medium, modeled here as pentyl ethanoate solvent, with an overall rate constant (koverall) of 2.01 × 102 M−1 s−1. However, significant antiradical activity is predicted for the aqueous medium (koverall = 2.60 × 105 M−1s−1) that is equivalent to the activity of the reference antioxidant Trolox. In a screen performed on a range of radicals, HO•, NO2, SO4•−, N3•, CH3O•, CCl3O•, CH3OO•, and CCl3OO• were also successfully scavenged by CMN in water at physiological pH. Therefore, other than a potent drug, CMN is also a good antioxidant in polar environments.
QUALISED cruise,Catherine Laurence R/V
Creators: name: FERNEX François
Publisher: name: Sismer
Year: 1986

description: Définition de la qualité des sédiments marins (pédologie sous-marine), de leur état de santé. Comparaison des propriétés géochimiques et biogéochimiques des sédiments devant l'embouchure d'un fleuve et devant un émissaire d'eaux urbaines usées (sans traitement avant le rejet). Le rattachement au projet national est QUALISED + CNRS ATP Géologie-Géophysique des Océans. Le projet international de rattachement est Commission des Communautés Européennes, Environmental Research Programme. La mission QUALISED est effectuée en mars, août et novembre 1986.
Me mam, digaset er gouleu
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2024

Abstract
DEP Bulletin - 2023 - Volume 47 Issue 15
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 2023

description: The DEP bulletin is a semi-monthly publication of the New Jersey Department of Environmental Protection. It contains a list of construction permit applications recently filed or acted upon by the Department along with a calendar of events of interest, a schedule of public hearings, and Environmental Impact Statements acted upon during the period.
Was ist Mentalisierungsfördernde Verhaltenstherapie MVT? Ein metakognitiv-therapeutischer Beitrag zur dritten Welle
Creators: name: Theßen, Lars
name: Sulz, Serge K. D.
Publisher: name: EUPEHS Research Centre
Year: 2024
Subjects: subject: Mentalisierungsförderung
subject: Emotion Tracking
subject: Kognitive Verhaltenstherapie
subject: Strategisch-Behaviorale Therapie SBT
subject: Überlebensregel
subject: Bindungssicherheit
subject: Achtsamkeit
subject: Akzeptanz
subject: Entwicklung
subject: Theory of Mind TOM
subject: 150

description: Deutsche Übersetzung des Artikels: Theßen, L., & Sulz, S. K. D. (2024). What is mentalization supporting therapy (MST)? A metacognitve-psychotherapeutic approach based on developmental psychology. European Psychotherapy: Scientific Journal for Psychotherapeutic Research and Practice, 15, 31-64. Der Original-Artikel hat ein Peer Review erhalten.
description: Mentalisierungsfördernde Verhaltenstherapie (MVT) ist eine Weiterentwicklung der Strategisch-Behavioralen Therapie SBT. Zu deren Therapiemodulen werden zwei neue Module hinzugefügt: Emotion Tracking – eine Adaption von Albert Pessos Microtracking zur Anwendung in der Kognitiven Verhaltenstherapie (KVT) – und Mentalisierungsförderung – eine Adaption der MBT-Fragetechnik. Während die Mentalisierungsbasierte Therapie MBT ein psychoanalytisch begrundete Therapiemethode innerhalb der Psychodynamischen Therapie ist, ist das Mentalisierungsmodul der MVT ein kognitiv-behaviorales Instrument zum Aufbau einer realitätsgerechetn Theory of Mind (TOM). Diese beiden Module sind zum Kern der MVT geworden und sind damit eine allgemeine psychotherapeutische Basiskompetenz, die u.E. in keiner Therapie fehlen darf. Die Behandlung schreitet vom 1. Modul: sichere Bindung in der therapeutischen Beziehung herstellen zum 2. Modul: die dysfunktionale Überlebensregel aus den Verletzungen der Kindheit extrahieren und in eine Erlaubnis gebende Lebensregel verwandeln, weiter zum 3. Modul: durch Achtsamkeit Gefühle wahrnehmen und akzeptieren: Dann kommen die beiden genannten neuen Module (Emotion Tracking und Mentalisierungsförderung), gefolgt von den beiden Entwicklungsmodulen (6. Entwicklung von der Affekt- auf die Denken-Stufe und 7. Entwicklung von der Denken- auf die Empathiestufe, deren Ziel funktionale Affektregulierung und Beziehungsfähigkeit im Sinne von Empathie und Mitgefühl ist.).
Flying under the radar? Education for sustainable development in private pilot training
Creators: name: Stiebe, Michael
Publisher: name: Zenodo
Year: 2023
Subjects: Private Pilot Training
Sustainable Aviation
General Aviation
Transformative Learning
Education for Sustainable Development

description: Aim: Private pilot (PPL(A)) training has hardly received any scholarly attention from educational and sustainability science perspectives. Through an Education for Sustainable Development (ESD) perspective, the study aimed at 1) answering how sustainability and sustainable development (SD) are taught in pertinent PPL(A) theory learning material, theory lessons and practical training, 2) identifying gaps pertaining to sustainability and SD in those three components, and lastly 3) explore if and how certificated flight instructors, theory instructors and student pilots experience transformative learning during PPL(A) training, as well as what possibilities these stakeholders see in supporting transformative learning in PPL(A) training.
Theory: This study was framed in the research paradigm of pragmatism. The theoretical lens through which the research problem was investigated was on a general level ESD. Within the context of ESD, the research used the perspective of Mezirowian Transformative Learning Theory.
Method: Focusing on Switzerland, this multi-methods study combined secondary and empirical methods. Firstly, a thematic document analysis (following Braun and Clarke) was applied to the two main PPL(A) learning materials. Secondly, semi-structured interviews with three certificated flight instructors (CFIs), one current student pilot, and two recently certificated private pilots were conducted. The interview analysis was conducted analogously to the document analysis. The results from both analyses were triangulated to answer the research questions.
Results: The study found that sustainability and SD were not adequately addressed in PPL(A) learning material and theory lessons, and only slightly more in practical training. This highlights the need to include sustainability and SD in all aspects of PPL(A) training, including the practical training syllabus to induce disorienting dilemmas in students. The study also suggests transforming the role of the CFI to become an educator that serves as a facilitator and provocateur in the Mezirowian sense of transformative learning. Applying a transformative ESD approach has the potential to catalyze sustainability in PPL(A) training, GA, and even the commercial aviation sector due to potential spillover effects.
description: + ID der Publikation: hslu_100949 + Art des Beitrages: Master-/Lizentiats-/Diplomarbeit + Name der Universität / Institution inkl. Ort: Göteborgs Universitet + Land der Universität / Institution: Schweden + Sprache: Englisch + Letzte Aktualisierung: 2024-07-30 13:12:32
Nitric oxide is an irreversible human diamine oxidase inhibitor
Creators: name: Kosta, Felix
name: Gludovacz, Elisabeth
name: Figl, Rudolf
name: Borth, Nicole
name: Jilma, Bernd
name: Boehm, Thomas
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Marine Biology
subject: Cancer
subject: Hematology

description: Diamine oxidase (DAO) histamine-degradation rates are compromised in plasma of mastocytosis patients during severe mast cell activation events. Mast cell-liberated histamine induces the release of nitric oxide (NO) close to DAO extracellular storage sites. We hypothesized that NO inhibits DAO activity. Recombinant human DAO activity was measured after incubation with NO-releasing NONOates (R1R2N−(NO−)−N = O). Topaquinone reactivity was quantified by absorption measurements and by mass spectrometry. Several murine models of NO-production were assessed for DAO activity inhibition in vivo. Nitric oxide released from NONOates dose dependently and irreversibly inhibited DAO activity. The NO scavengers Trolox (Vitamin E derivative) and 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (C-PTIO), the reversible DAO inhibitors diminazene and ciproxifan, the substrates histamine (EC50 = 32 µM) and putrescine (EC50 = 39 µM), heparin whole blood and plasma protected DAO from inhibition. Nitric oxide reduced the reactivity of topaquinone to phenylhydrazine by 90%. None of the NO producing in vivo models showed DAO inhibition in plasma or tissue. Nitric oxide is a potent irreversible DAO inhibitor in vitro representing the first discovered natural inhibitor for this enzyme. Endogenous mouse DAO inhibition in vivo could not be demonstrated. The true nature of human DAO activity inhibition during severe mastocytosis events remains unknown.
Intervención psicopedagógica para la asignatura de instrumento. Alumno con TEA en conservatorio de música.
Creators: name: Ana Herráiz Alijas
Publisher: name: Zenodo
Year: 2024

description:    Ejemplo de intervención psicopedagógica en el ámbito de las enseñanzas formales de música para un alumno con trastorno del espectro del autismo (TEA) dirigida a la clase de instrumento.
QUALOP 1 cruise,L'Europe R/V
Creators: name: OPDERBECKE Jan
Publisher: name: Sismer
Year: 2007

description: La campagne QUALOP1 s'inscrit dans le transfert de l'AUV2 de l'IFREMER à GENAVIR. Les essais techniques réalisés lors de la campagne permettent de qualifier le fonctionnement, les performances et les modes opératoires du système. Le deuxième objectif est la formation des équipes opérationnelles à l'opération de l'AUV. Le programme de rattachement est AUV's côtiers (Phase 1) PJA0103.La campagne s'est déroulée dans 2 zones:Zone 1 : Cap Lardier (43 deg 14' N ; 6 deg 43' E // 43 deg 09' N ; 6 deg 50' E) ; Zone 2 : Cavalaire (43 deg 11' N ; 6 deg 36' E // 43 deg 09' N ; 6 deg 34' E).
OXIPRO's 7th Newsletter
Creators: name: Tobin de Fuentes, Lesley
Publisher: name: Zenodo
Year: 2025

description: As OXIPRO nears its formal conclusion this May, the project’s spirit of innovation shows no signs of slowing down. Our four-year journey has delivered tangible scientific breakthroughs — like a cuttingedge enzyme screening platform, cleaner cotton bleaching, and enzyme-powered laundry disinfection alternatives, and characterized a novelbacterial lactoperoxidase with potential in food preservation and personal care products. Beyond the lab, our engagement with European stakeholders has brought forward two new policy briefs on emerging frameworks that could shape the enzyme field. Through three events in Madrid, we closed ranks with sister projects to reflect on shared messages: stakeholder inclusion, sustainability through action, and the cultural shifts needed to unlock the biotech potential. Biotechnology can’t solve everything, but it can do more than we often imagine. Researchers, industry, and policymakers alike must continue to build alliances, lead change, and raise awareness. OXIPRO has shown what’s possible when knowledge meets purpose. We hope you enjoy exploring this issue and find it of interest.
Involvement of iron ions in 6-hydroxydopamine-induced disruption of intracellular copper metabolism
Creators: name: Kato, Ami
name: Tani, Ayano
name: Kamijo, Fuka
name: Otsuka, Tomohiro
name: Kamiya, Tetsuro
name: Hara, Hirokazu
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified

description: Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra. Recently, disorders in metabolism of metals, including copper (Cu) and iron (Fe), have been reported to be linked to the pathogenesis of PD. We previously demonstrated that 6-hydoroxydopamine (6-OHDA), a neurotoxin used for the production of PD model animals, decreases Atox1, a Cu chaperone, and ATP7A, a Cu transporter, and disrupts intracellular Cu metabolism in human neuroblastoma SH-SY5Y cells. However, the exact mechanisms remain unclear. Meanwhile, intracellular Fe modulates 6-OHDA-induced cellular responses. In this study, we investigated whether Fe participates in 6-OHDA-induced abnormality in Cu metabolism. 6-OHDA-induced reactive oxygen species (ROS) production and cellular injury were suppressed by Fe chelators, deferoxamine and 2,2’-bipyridyl (BIP). These chelators also restored 6-OHDA-induced degradation of Atox1 and ATP7A proteins and subsequent Cu accumulation, indicating that intracellular Fe is involved in the disruption of Cu homeostasis associated with 6-OHDA. Atox1 has redox-sensitive cysteine (Cys) residues in its Cu-binding site. The Cys residues of Atox1 were oxidized by 6-OHDA, and BIP suppressed their oxidation. Moreover, the replacement of Cys with histidine in the Cu-binding site conferred resistance to 6-OHDA-induced Atox1 degradation. These results suggest that oxidized modification of Atox1 by 6-OHDA is likely to accelerate its degradation. Thus, we conclude that Fe and Cu metabolisms are closely related to each other in the pathogenesis of PD.
ResearchBox 488, 'GE Germany', https://researchbox.org/488
Creators: name: Yoel Inbar
name: Gabi Waldhof
Publisher: name: Zenodo
Year: 2025

description: Box title: 'GE Germany'   Reference: Yoel Inbar; Gabriela Waldhof, 'Mitigating Consequence Insensitivity for Genetically Engineered Crops', Journal of Experimental Psychology: AppliedNote: this backup was created automatically by a ResearchBox bot
QUICKSEINE 98 cruise,Thalia R/V
Creators: name: AMINOT Alain
name: MENESGUEN Alain
name: GUILLAUD Jean-François
Publisher: name: Sismer
Year: 1998

description: Les campagnes Quickseine sont prévues pour étudier le cycle des nutriments, du phytoplancton et du zooplancton dans trois masses d'eau types dont les salinités de surface sont de 27-29, 31-32 et 34-35. Dans ces campagnes, il n'y a donc pas de station fixe.Les dates, navires et chefs de mission des campagnes QUICKSEINE sont respectivement : 1: du 04 au 05 mars (CÔTES DE LA MANCHE) - Alain Menesguen;2: du 02 au 03 avril (THALIA) - Alain Aminot;3: du 05 au 06 mai;3TER: du 17 au 18 mai;4: du 31 mai au 01 juin (THALIA) - Alain Menesguen; 5: du 08 au 09 juillet (THALIA) - Jean-François GUILLAUD;6: du 17 au 19 août;7: du 22 au 24 septembre;Le projet de rattachement est PNEC.
Representation of modelling and simulation driven research workflows as cognitive processes for ontology-based knowledge and data management in the engineering sciences
Creators: name: Horsch, Martin Thomas
Publisher: name: Zenodo
Year: 2022
Subjects: interoperability
digitalization
simulation workflows
applied ontology
process data technology

description: This position paper argues that FAIR research data management and semantically interoperable knowledge representation in computational engineering are best advanced by a system of semantic artefacts and tools that are based on a formal model of cognitive processes and the main outcome of cognitive processes: Knowledge claims. Such an approach emphasizes what modelling and simulation have in common with other practices and processes, in scientific research and beyond, and will therefore be particularly amenable to ontology alignment and the integration of data from heterogeneous sources within data infrastructures.
R.V VEMA LEG I CH77 cruise,Jean Charcot R/V
Creators: name: NEEDHAM Hubert David
Publisher: name: Sismer
Year: 1977

description: La campagne BIOVEMA avait un double objectif : de déterminer le rôle de la fracture VEMA (11N, Océan Atlantique) dans les échanges faunistiques Ouest-Est au niveau des communautés abyssales de l'Atlantique tropical, de préciser la répartition spatiale des organismes de profondeur sur une échelle réduite (modèle de micro-distribution) à l'aide de prélèvements répétés.
VDIS: A System for Morphological Detection & Identification of Vehicles in RGB images
Creators: name: Mahabir, Ron
name: Gonzales, Kevin
name: Silk, Jared
Publisher: name: George Mason University
Year: 2015
Subjects: Vehicle detection; vehicle identification, traffic, image spectra

description: With the growth of urban centers worldwide, the number of vehicles in and around these areas has also increased. Traffic-related data plays an important role in spatial planning, for example, optimizing road networks and in the estimation or simulation of air and noise pollution. This information is important as it reflects the changes taking place around us. Additionally, data collected can be used for a wide array of applications including law enforcement, fleet management, and supporting other analyses at varying scales. In this paper, we present a method for the detection and identification of vehicles from low altitude, high spatial resolution Red Blue Green (RGB) images, utilizing both object spectra and image morphology. Results show an identification performance upwards of 62% with false positives occurring from the use of images with sun glare and vehicles with similar spectra values.
description: Journal of Mason Graduate Research, Vol 2, No 2 (2015): Scholarly Innovation
Na cheleuet, kompagnuneh
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2024

Abstract
title: The Role of Campus Surroundings in Student Retention: A Confirmatory Factor Analysis of the Campus Surroundings Construct
Creators: name: Kellard, Laura E.
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 2000

description: The present study developed and examined a new construct, Campus Surroundings, in the college student retention process. Based on previous research, it was hypothesized that different aspects of the campus environment might affect student retention. The three major aspects analyzed in the questionnaire included the students' satisfaction with (1) the appearance or impression of the campus, (2) the safety of the campus, and (3) specific aspects of campus life. The twenty-nine-item scale was administered by mail to 1,195 traditional freshmen at a large urban institution. Results from the 307 respondents were examined using confirmatory factor analysis and measurement model assessment. Analysis of the final measurement model revealed relatively strong support for the Campus Surroundings construct and evidence for the three hypothesized aspects. Suggestions for future development and research of the construct were made based on the results of the study.
Shi'i Resistance — Contextual Activism
Creators: name: Ludt, Thomas
Publisher: name: George Mason University
Year: 2015

description: The notion of Shi’ism as a sect characterized by activism and resistance is incomplete. Throughout the course of Shi’i history, there have been a variety of circumstances, which require a muted understanding of activism and resistance. Born out of persecution and pragmatism, the Shi’a have incorporated a variety of doctrines that allow for the expression of resistance in a variety of overt and covert contexts. This “contextual activism” has not only resulted in the survival of the Shi’i sect, but has also provided for the lasting integrity of the Shi’i community.
description: Journal of Mason Graduate Research, Vol 2, No 2 (2015): Scholarly Innovation
R.V VEMA LEG II CH78 cruise,Jean Charcot R/V
Creators: name: NEEDHAM Hubert David
Publisher: name: Sismer
Year: 1977

description: La campagne BIOVEMA avait un double objectif : déterminer le rôle de la fracture VEMA dans les échanges faunistiques Ouest-Est au niveau des communautés abyssales de l'Atlantique tropical, préciser la répartition spatiale des organismes de profondeur sur une échelle réduite (modèle de micro-distribution) à l'aide de prélèvements répétés.
Main Supplementary File from Termite dispersal is influenced by their diet
Creators: name: Hellemans, Simon
name: Sobotnik, Jan
name: Lepoint, Gilles
name: Mihaljevic, Martin
name: Roisin, Yves
name: Bourguignon, Thomas
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology

description: Centralizes all supplementary files, data, figures, tables and references.
R.V VEMA LEG III CH79 cruise,Jean Charcot R/V
Creators: name: CHARDY Pierre
Publisher: name: Sismer
Year: 1977

description: Etude de la composition et de la structure de la croute océanique durant les quelques derniers millions d'années de son évolution, y compris les thèmes : structure, pétrologie et géochimie des grandes zones de fracture, des rides transversales et de la dorsale à l'âge zéro ; déformation des sédiments et courants de fond. Cette opération se situe dans le cadre de l'opération du CNEXO "Croute océanique".
ResearchBox 501, 'Source Memory', https://researchbox.org/501
Creators: name: Daniel Mirny
name: Stephen Spiller
Publisher: name: Zenodo
Year: 2025

description: Box title: 'Source Memory'   Reference: Daniel J Mirny, Stephen A Spiller, 'Source Memory Is More Accurate for Opinions Than for Facts', Journal of Consumer ResearchNote: this backup was created automatically by a ResearchBox bot
Here and Nowhere: A Critical Analysis of Geomusicology
Creators: name: Purdy, Britnae A.
Publisher: name: George Mason University
Year: 2015
Subjects: Geomusicology, geopolitics, Wallerstein, O’Tuathhail, music, geography

description: Geomusicology, the study of the geography of music, encompasses themes such as patriotism, politics, sense of identity, history, ethnicity, and more, making it a crucial, if often overlooked component of geopolitics. As a relatively new field of research, geomusicology warrants more attention to determine its ability to contribute to geopolitics. However, the major themes of the field are at times contradictory and abstract, calling for a subtle and nuanced understanding of research in the field. This paper provides an overview of some major literature in geomusicology and concludes that most researchers in the field believe that music is both anchored by place and universal at the same time. Using a critical approach to geopolitics, this paper thus debates the strengths and weakness of geomusicology with recommendations on how to further evolve the field to contribute to a fuller understanding of geopolitics as a whole.
description: Journal of Mason Graduate Research, Vol 2, No 2 (2015): Scholarly Innovation
CRAFT-OA Tech Event 2024
Creators: name: Bargheer, Margo
name: Varachkina, Hanna
name: Gomola, Radek
name: Dvořáková, Martina
name: Jertec Musap, Ljiljana
name: Celjak, Draženko
name: Gingold, Arnaud
name: Cuel Oller, Nathan
name: Růžička, Michal
name: Pispiringas, Leonidas
name: Fenner, Jorina
name: Rosiński, Cezary
name: Umerle, Tomasz
name: Kupreyev, Maxim
name: Meinecke, Isabella
Publisher: name: Zenodo
Year: 2024

description: These presentations were given at the CRAFT-OA Tech Event, which took place from 10-11 October 2024.
RADE 3D cruise,Thalia R/V
Creators: name: MARSSET Bruno
Publisher: name: Sismer
Year: 1996

description: Mise au point des méthodes d'acquisition de sismique Très Haute résolution tridimensionnelle de manière à fournir un premier jeu de données nécessaire à la validation de la méthode.Le projet de rattachement est Sismique THR 3D.
Genome-wide studies reveal factors associated with circulating uromodulin and its relations with complex diseases
Creators: name: Li, Yong
name: Cheng, Yurong
name: Consolato, Francesco
name: Schiano, Guglielmo
name: Chong, Michael R.
name: Pietzner, Maik
name: Nguyen, Ngoc Quynh H.
name: Scherer, Nora
name: Biggs, Mary L.
name: Kleber, Marcus E.
name: Haug, Stefan
name: Göçmen, Burulça
name: Pigeyre, Marie
name: Sekula, Peggy
name: Steinbrenner, Inga
name: Schlosser, Pascal
name: Joseph, Christina B.
name: Brody, Jennifer A.
name: Grams, Morgan E.
name: Hayward, Caroline
name: Schultheiss, Ulla T.
name: Krämer, Bernhard K.
name: Kronenberg, Florian
name: Peters, Annette
name: Seissler, Jochen
name: Steubl, Dominik
name: Then, Cornelia
name: Wuttke, Matthias
name: März, Winfried
name: Eckardt, Kai-Uwe
name: Gieger, Christian
name: Boerwinkle, Eric
name: Psaty, Bruce M.
name: Coresh, Josef
name: Oefner, Peter J.
name: Pare, Guillaume
name: Langenberg, Claudia
name: Scherberich, Jürgen E.
name: Yu, Bing
name: Akilesh, Shreeram
name: Devuyst, Olivier
name: Rampoldi, Luca
name: Köttgen, Anna
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: Chronic kidney disease; Genetics; Nephrology; Population genetics
subject: 610 Medizin

description: UMOD is a major risk gene for monogenic and complex forms of kidney disease. The encoded kidney-specific protein uromodulin is highly abundant in urine and related to chronic kidney disease, hypertension, and pathogen defense. To gain insights into potential systemic roles, we performed genome-wide screens of circulating uromodulin using complementary antibody-based (N=13,985) and aptamer-based (N=18,070) assays. We detected 3 and 10 distinct significant (p<5e-8) loci, respectively. Integration of antibody-based results at the UMOD locus with functional genomics data (RNA-seq, ATAC-seq, Hi-C) of primary human kidney tissue highlights an upstream variant with differential accessibility and transcription in uromodulin-synthesizing kidney cells as underlying the observed cis effect. Shared association patterns with complex traits, including chronic kidney disease and blood pressure, place the PRKAG2 locus in the same pathway as UMOD. Experimental validation of the third antibody-based locus, B4GALNT2, shows that the p.Cys466Arg variant of the encoded N-acetylgalactosaminyltransferase has a loss-of-function effect leading to higher serum uromodulin levels. Aptamer-based results point to enzymes writing glycan marks present on uromodulin and to their receptors in the circulation, suggesting that this assay permits investigating uromodulin's complex glycosylation rather than its quantitative levels. Overall, our study provides new insights into circulating uromodulin and its emerging functions.
title: Understanding the Organizational Nature of Student Persistence: Empirically-Based Recommendations for Practice
Creators: name: Berger, Joseph B
Publisher: name: University of Massachusetts Amherst
Year: 2001
Subjects: subject: Equity and Access
subject: Educational Assessment, Evaluation, and Research
subject: Higher Education

description: This article builds on the assumption that colleges and universities are organizations and subsequently that the organizational perspective provides important insights for improving retention on college and university campuses. A review of existing organizational studies of undergraduate persistence serves as the basis for ten empirically-based recommendations for practice that are designed to help campus leaders improve the effectiveness of retention efforts on campus.
Mason Interdisciplinary Graduate Conference Abstracts
Creators: name: GAPSA, JMGR
Publisher: name: George Mason University
Year: 2015

description: The abstracts contained in this issue were presented at the 2015 Mason Interdisciplinary Graduate Conference hosted by the George Mason University’s Graduate and Professional Student Association (GAPSA). The conference was held March 20, 2015 at the Mason Global Center and was open to the entire George Mason community with pre-conference workshops held on March 19th.
description: Journal of Mason Graduate Research, 2015: Mason Interdisciplinary Graduate Conference
ResearchBox 505, 'Methodological issues with VBDM tasks', https://researchbox.org/505
Creators: name: Amber Copeland
name: Tom Stafford
name: Matt Field
Publisher: name: Zenodo
Year: 2025

description: Box title: 'Methodological issues with VBDM tasks'   Reference: Tom Stafford, Matt Field, 'Methodological issues with value-based decision-making (VBDM) tasks: the effect of trial wording on evidence accumulation outputs from the EZ drift-diffusion model ', Cogent Psychologyhttps://psyarxiv.com/va2znNote: this backup was created automatically by a ResearchBox bot
En estig hag en ulir
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2024

Abstract
Obesity and C-Reactive Protein, Immunoglobulins, and Lipids
Creators: name: Alsufyani, Amal Abdulaziz
Publisher: name: George Mason University
Year: 2016
Subjects: Obesity, C-Reactive Protein, Immunoglobulins, Lipids, Body Mass Index, Waist to Hip Ratio.

description: Obesity has been increasing in rich oil producing countries, such as Saudi Arabia, for the last few decades. Weight above the healthy level is suggested to interfere with normal immune function, affecting both innate and acquired immune responses. This study aimed to determine the relationship between increased weight and serum concentrations of C-reactive protein (CRP), Immunoglobulin (Ig)G, IgM, IgA, and the lipid profile. One hundred and nineteen randomly chosen Saudi female college students were assessed for their weight status using the body mass index (BMI) and the waist-to-hip ratio (WHR). Findings show that as the BMI and WHR increase, the CRP levels increase highly significantly compared to the controls. IgA levels also increase significantly as the BMI and WHR increase. Conversely, both IgG and IgM levels are not affected by the BMI or WHR. As for the lipid profile, cholesterol concentrations rise highly significantly as the WHR increases, but it is not affected by the BMI. Triacylglycerols and LDL levels increase highly significantly, while HDL decreases highly significantly in association with BMI and WHR increase. Multiple comparisons between the BMI and WHR groups were also investigated. In conclusion, increasing weight and obesity is correlated with an increase in CRP concentration, suggesting the presence of a state of harmful unspecific inflammation. The observed increase in IgA with the increase of weight and obesity agrees with findings by other researchers of increased respiratory infections in obese individuals. Finally, it is also concluded that overweight and obesity are associated with an unfavorable lipid profile, which is known to be detrimental to health and the immune system.
description: Journal of Mason Graduate Research, Vol 3, No 1 (2016): Addressing Complex Global Issues
Cost-effectiveness analysis of sintilimab + chemotherapy versus camrelizumab + chemotherapy for the treatment of first-line locally advanced or metastatic nonsquamous NSCLC in China
Creators: name: Rui, Mingjun
name: Fei, Zhengyang
name: Wang, Yingcheng
name: Zhang, Xueke
name: Ma, Aixia
name: Sun, Haikui
name: Li, Hongchao
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Sintilimab is a selective PD-1 inhibitor with efficacy in advanced or metastatic nonsquamous non-small-cell lung cancer (NSCLC) patients. This study evaluated the cost-effectiveness of sintilimab + chemotherapy versus camrelizumab + chemotherapy as the first-line treatment for locally advanced or metastatic nonsquamous NSCLC in Chinese patients. In addition, this study aimed to reveal the impact of the reference treatment choice on the incremental cost-effectiveness ratio (ICER) results. A partitioned survival model (PSM) with three health states was constructed in a 3-week cycle with a lifetime horizon from the Chinese healthcare system perspective. Anchored matching adjusted indirect comparison was used for survival analyses based on individual patient data from Orient-11. Sintilimab + chemotherapy was chosen as the reference treatments in scenarios 1 and 2, while the camrelizumab + chemotherapy was chosen as the reference treatments in scenario 3. The utility values of different health states were derived from the patient-level European Organization for Research and Treatment Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) scores by mapping to the EQ-5D-5L, and QALYs were calculated as the health outcomes. One-way deterministic sensitivity analysis (DSA) and probability sensitivity analysis (PSA) were performed to explore model uncertainty. Compared to camrelizumab + chemotherapy, sintilimab + chemotherapy was associated with higher effectiveness (incremental QALYs ranged from 0.13–0.62) and lower total costs (incremental costs ranged from $1,099–$5,201), resulting in an ICER ranging from $6,440–$8,454/QALY. Sintilimab + chemotherapy is a cost-effective option compared with camrelizumab + chemotherapy as the first-line treatment for locally advanced or metastatic nonsquamous NSCLC in China.
Saving Face or Saving Society?
Creators: name: Bradley, Shelley Elizabeth
Publisher: name: George Mason University
Year: 2015
Subjects: Nonprofit; Nonprofit Management; Nonprofit Marketing; Strategic Fundraising; Charitable Contributions; Public Relations

description: This paper examines private sector models imported to the public sector in the context of nonprofit fundraising. A review of current literature finds “bottomline” approaches to management ineffective in nonprofit organizations, but indicates prescriptive benefits of public relations/marketing strategies. Research cautions that nonprofits must not conduct excessive fundraising and should carefully manage donor-fundraiser relationships. Future studies are needed to explore fundraising and should carefully manage donor-fundraiser relationships.
description: Journal of Mason Graduate Research, Vol 2, No 1 (2015): Scholarly Innovation
ResearchBox 506, 'Tracing-Technology Adoption ', https://researchbox.org/506
Creators: name: Sarah Geber
name: Thomas Friemel
Publisher: name: Zenodo
Year: 2025

description: Box title: 'Tracing-Technology Adoption '   Reference: Sarah Geber ; Thomas Friemel , 'Tracing-Technology Adoption During the COVID-19 Pandemic: The Multifaceted Role of Social Norms', International Journal of CommunicationNote: this backup was created automatically by a ResearchBox bot