title: ÐÐ¸ÑÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ°Ñ ÐºÐ°ÑÑÐ¸Ð½Ð° Ð¾ÑÐ³Ð°Ð½Ð¾Ð² Ð¸ ÑÐºÐ°Ð½ÐµÐ¹ ÐºÑÑÑ Ð¿ÑÐ¸ Ð´Ð»Ð¸ÑÐµÐ»ÑÐ½Ð¾Ð¹ Ð¸Ð¼Ð¿Ð»Ð°Ð½ÑÐ°ÑÐ¸Ð¸ Ð¼ÐµÑÑÐ½Ð¾Ð³Ð¾ Ð³ÐµÐ¼Ð¾ÑÑÐ°ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÑÐµÐ´ÑÑÐ²Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Histological picture of rat organs and tissues during prolonged implantation of a local hemostatic agent
Creators: name: ÐÑÐ¾ÑÐºÑÑÑÐºÐ¾Ð²Ð°, ÐÐ»ÐµÐºÑÐ°Ð½Ð´ÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: Ð¼ÐµÑÑÐ½Ð¾Ðµ Ð³ÐµÐ¼Ð¾ÑÑÐ°ÑÐ¸ÑÐµÑÐºÐ¾Ðµ ÑÑÐµÐ´ÑÑÐ²Ð¾
Ð±ÐµÐ·Ð¾Ð¿Ð°ÑÐ½Ð¾ÑÑÑ
Ð´Ð¾ÐºÐ»Ð¸Ð½Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ
Ð¸Ð¼Ð¿Ð»Ð°Ð½ÑÐ°ÑÐ¸Ñ
local hemostatic agent
safety
preclinical studies
implantation

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ Ð¾Ð±ÑÐµÑÐ¾ÐºÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¸ Ð¼ÐµÑÑÐ½Ð¾Ð³Ð¾ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð¿Ð¾ÑÐ»Ðµ Ð¸Ð¼Ð¿Ð»Ð°Ð½ÑÐ°ÑÐ¸Ð¸ Ð¼ÐµÑÑÐ½Ð¾Ð³Ð¾ Ð³ÐµÐ¼Ð¾ÑÑÐ°ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÑÐµÐ´ÑÑÐ²Ð° (ÐÐÐ¡) Ð´Ð»Ñ Ð²Ð½ÑÑÑÐ¸Ð¿Ð¾Ð»Ð¾ÑÑÐ½Ð¾Ð³Ð¾ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð½Ð° Ð¿Ð¾Ð»Ð¾Ð²Ð¾Ð·ÑÐµÐ»ÑÑ ÐºÑÑÑÐ°Ñ. Ð ÐºÐ°ÑÐµÑÑÐ²Ðµ ÑÐµÑÑ-ÑÐ¸ÑÑÐµÐ¼Ñ Ð±ÑÐ»Ð¸ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ñ Ð±ÐµÑÐ¿Ð¾ÑÐ¾Ð´Ð½ÑÐµ ÐºÑÑÑÑ ÑÐ°Ð¼ÑÑ Ð¸ ÑÐ°Ð¼ÐºÐ¸, Ð²Ð¾Ð·ÑÐ°ÑÑÐ¾Ð¼ 3 Ð¼ÐµÑÑÑÐ°. ÐÐ¼Ð¿Ð»Ð°Ð½ÑÐ°ÑÐ¸Ñ ÐÐÐ¡ Ð² Ð±ÑÑÑÐ½ÑÑ Ð¿Ð¾Ð»Ð¾ÑÑÑ Ð¾ÑÑÑÐµÑÑÐ²Ð»ÑÐ»Ð°ÑÑ Ð¾Ð´Ð½Ð¾ÐºÑÐ°ÑÐ½Ð¾. Ð ÑÐ¾Ð´Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¾ÑÐµÐ½Ð¸Ð²Ð°Ð»Ð¸ Ð²ÑÐ¶Ð¸Ð²Ð°ÐµÐ¼Ð¾ÑÑÑ, ÐºÐ»Ð¸Ð½Ð¸ÑÐµÑÐºÑÑ ÐºÐ°ÑÑÐ¸Ð½Ñ Ð¸Ð½ÑÐ¾ÐºÑÐ¸ÐºÐ°ÑÐ¸Ð¸, Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Ð½Ð° Ð¼Ð°ÑÑÑ ÑÐµÐ»Ð°, Ð²Ð¾Ð´Ð¾- Ð¸ ÐºÐ¾ÑÐ¼Ð¾Ð¿Ð¾ÑÑÐµÐ±Ð»ÐµÐ½Ð¸Ðµ; Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸Ð»Ð¸ Ð¸Ð·ÑÑÐµÐ½Ð¸Ðµ Ð²Ð½ÑÑÑÐµÐ½Ð½Ð¸Ñ Ð¾ÑÐ³Ð°Ð½Ð¾Ð² Ð¼Ð°ÐºÑÐ¾- Ð¸ Ð¼Ð¸ÐºÑÐ¾ÑÐºÐ¾Ð¿Ð¸ÑÐµÑÐºÐ¸Ð¼Ð¸ Ð¼ÐµÑÐ¾Ð´Ð°Ð¼Ð¸, ÑÑÐ°Ð²Ð½Ð¸Ð²Ð°Ð»Ð¸ Ð¼Ð°ÑÑÐ¾Ð²ÑÐµ ÐºÐ¾ÑÑÑÐ¸ÑÐ¸ÐµÐ½ÑÑ Ð¾ÑÐ³Ð°Ð½Ð¾Ð² Ð¸ Ð¾ÑÐµÐ½Ð¸Ð²Ð°Ð»Ð¸ Ð¼ÐµÑÑÐ½Ð¾Ðµ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ Ð¿Ð¾ÑÐ»Ðµ Ð¸Ð¼Ð¿Ð»Ð°Ð½ÑÐ°ÑÐ¸Ð¸. Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð±ÑÐ»Ð¾ ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð¾, ÑÑÐ¾ Ð¿Ð¾ÑÐ»Ðµ Ð¸Ð¼Ð¿Ð»Ð°Ð½ÑÐ°ÑÐ¸Ð¸ Ð¸ÑÑÐ»ÐµÐ´ÑÐµÐ¼Ð¾Ð³Ð¾ Ð¾Ð±ÑÐ°Ð·ÑÐ° Ð² Ð±ÑÑÑÐ½ÑÑ Ð¿Ð¾Ð»Ð¾ÑÑÑ Ð² Ð´Ð¾Ð·Ðµ 512 Ð¼Ð³/ÐºÐ³ Ð½Ðµ Ð±ÑÐ»Ð¾ Ð·Ð°ÑÐµÐ³Ð¸ÑÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¾: Ð³Ð¸Ð±ÐµÐ»Ð¸ Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑ, ÑÐ¿ÐµÑÐ¸ÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¿ÑÐ¸Ð·Ð½Ð°ÐºÐ¾Ð² Ð¸Ð½ÑÐ¾ÐºÑÐ¸ÐºÐ°ÑÐ¸Ð¸, Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ð¹ ÑÑÑÑÐºÑÑÑÑ Ð²Ð½ÑÑÑÐµÐ½Ð½Ð¸Ñ Ð¾ÑÐ³Ð°Ð½Ð¾Ð², Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ð¹ Ð·Ð½Ð°ÑÐµÐ½Ð¸Ñ Ð¼Ð°ÑÑÐ¾Ð²ÑÑ ÐºÐ¾ÑÑÑÐ¸ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ð¿Ð¾ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ñ Ñ ÐºÐ¾Ð½ÑÑÐ¾Ð»ÐµÐ¼. ÐÑÐ¸ Ð³Ð¸ÑÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð¼ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¸ Ð±ÑÑÑÐ¸Ð½Ñ Ð²ÑÑÐ²Ð»ÐµÐ½Ñ Ð¿ÑÐ¸Ð·Ð½Ð°ÐºÐ¸ Ð¼ÐµÑÑÐ½Ð¾ÑÐ°Ð·Ð´ÑÐ°Ð¶Ð°ÑÑÐµÐ³Ð¾ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð¿Ð¾ÑÐ»Ðµ Ð¸Ð¼Ð¿Ð»Ð°Ð½ÑÐ°ÑÐ¸Ð¸ Ð¸ÑÑÐ»ÐµÐ´ÑÐµÐ¼Ð¾Ð³Ð¾ Ð¾Ð±ÑÐ°Ð·ÑÐ°. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ Ð´Ð°Ð½Ð½ÑÐµ ÑÐ²Ð¸Ð´ÐµÑÐµÐ»ÑÑÑÐ²ÑÑÑ Ð¾ Ð½Ð¾ÑÐ¼Ð°Ð»ÑÐ½Ð¾Ð¹ Ð¿ÐµÑÐµÐ½Ð¾ÑÐ¸Ð¼Ð¾ÑÑÐ¸ Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÐ¼Ð¸ Ð¸Ð¼Ð¿Ð»Ð°Ð½ÑÐ°ÑÐ¸Ð¸ ÐÐÐ¡ Ð² Ð±ÑÑÑÐ½ÑÑ Ð¿Ð¾Ð»Ð¾ÑÑÑ Ð² Ð´Ð¾Ð·Ðµ 512 Ð¼Ð³/ÐºÐ³.
description: This work is devoted to the study of general toxic and local action after implantation of local hemostatic agent (LHA) for intracavitary application in sexually mature rats. Mute male and female rats, 3 months old, were used as a test system. Implantation of MGS into the abdominal cavity was performed once. During the study, survival rate, clinical picture of intoxication, effect on body weight, water and feed consumption were evaluated; internal organs were examined by macro- and microscopic methods, mass ratios of organs were compared and local effects after implantation were assessed. As a result of the study it was found that after implantation of the studied sample in the abdominal cavity at a dose of 512 mg/kg there were no: animal death, specific signs of intoxication, changes in the structure of internal organs, changes in the value of mass ratios compared to the control. The histological study of the peritoneum revealed signs of local irritating effect after implantation of the investigated sample. The obtained data indicate normal tolerance of animals to implantation of MGS in the abdominal cavity at a dose of 512 mg/kg.