cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Leucadendron xanthoconus thinning experiment in Hottentots Holland, Jakkalsrivier, site 3419AA/1/38
Creators: name: Jonkershoek Forestry Research Center
Publisher: name: South African Environmental Observation Network
Year: 2022
Subjects: Jonkershoek Forestry Research Centre
Hottentots Holland
Jakkalsrivier
Leucadendron xanthoconus

description: This is a scanned copy of a document on a Leucadendron xanthoconus thinning experiment in Hottentots Holland, Jakkalsrivier, site 3419AA/1/38. The Jonkershoek Forestry Research Center (part of the former South African Forestry Research Institute) was established in 1935 at Jonkershoek, near Stellenbosch, under the directorship of Dr C. L. Wicht. The initial aim was to determine how forestry activities in state plantations would affect climate, water conservation and erosion, and was later expanded to include studies of fynbos ecology, fire and alien species. Studies from the 1930s to the early 1990s saw the accumulation of a large amount of data dealing with fire experiments, detailed vegetation plot surveys, rare plant surveys and ecological studies, hydrological studies and the development of management plans for catchments around the Western Cape. SAEON now houses the archive of data collected by the Jonkershoek Forestry Research Center, which was originally held by the Council for Scientific and Industrial Research (CSIR).
Alsophila mostellaria Lehnert, Amer. Fern J.
Creators: name: Lehnert, Marcus
name: Kessler, Michael
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Cyatheales
Cyatheaceae
Alsophila
Alsophila mostellaria

description: Alsophila mostellaria Lehnert, Amer. Fern J. 93(4): 171. 2003.
 Range: — Ecuador to Bolivia (CO, LP).
 Ecology: —Widespread, rare but locally common, usually in small colonies in the understory of cloud forests; 1385–1450 m.
 Notes: — Alsophila mostellaria is superficially similar to A. setosa Kaulf. from southeastern Brazil and adjacent areas. Both species have relatively thin trunks, skeletonized pinnae at the petiole base and may form colonies in the forest understory by means of subterranean stolons. Alsophila mostellaria is most common in the Amtotape-Huancabamba region of southern Ecuador and northern Peru, and occurs only sporadically in Bolivia. The two neotropical species of the Gymnosphaera clade (A. capensis (L.f.) Sw., A. salvinii Hook.) also have skeletonized pinnae and may occur in Bolivia as well. They are recognized by the lack of prickles, and should be sought where the microclimate provides constant cool temperatures and regular daily mists.
description: Published as part of Lehnert, Marcus & Kessler, Michael, 2018, Prodromus of a fern flora for Bolivia. XX. Cyatheaceae, pp. 118-134 in Phytotaxa 334 (2) on page 121, DOI: 10.11646/phytotaxa.334.2.2, http://zenodo.org/record/13721436
title: TRANSLATING CITIES urban spaces in contemporary art mapping practices
Creators: name: Lanci da Silva, Maria da Gloria
Publisher: name: University of Liverpool Repository
Year: 2525

description: This project aims to investigate how cities are perceived, represented and enacted in contemporary art maps, analysing their aesthetic, informative and cultural meanings. The research approaches the diversity of contemporary mapping practices through a series of semi-structured interviews with artists, enquiring how they apprehend, process and re-create urban spaces in artworks. The focus of analysis is on the performative dimensions of art maps rather than on their representational aspects; performance being conceived as the capacity to re-imagine territories and incorporate imagined geographies in relation to physical reality. I discuss the idea of the art map as an open-ended practice that can unfold collective endeavour, personal narratives, contestation and protest, embodiment and play, and where knowledge is culturally produced. This discussion draws on academic debates that have been challenging traditional notions of maps as scientific artefacts for information and way finding, representing a neutral knowledge produced through accurate measurement and surveying. The research applies qualitative methods - interviews with artists and a case study in Liverpool, which illustrate our discussion of how contemporary art works can be related to traditional and non-traditional cartographies and how they promote new ways of understanding, experiencing and imagining urban spaces. I argue that art maps are work-in-progress and they are continuously performing. As cities are transformed through urban planning, political ideologies and socio-economic forces, art maps not only reflect these processes, but they embed knowledge to reinterpret and understand the very nature of urban spaces. The aim of this project is to interrogate how and why artistic production can shed some light in the comprehension of cities, approaching them as creative responses to the perception and understanding of the urban environment. Rather than debating intrinsic aesthetic qualities of artworks I am considering them as translations, or modes of interpretation and investigation of cities.
Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6
Creators: name: Citrin, Kathryn M.
name: Kushner, Erich J.
name: Barber, Andrew T.
name: Park, Youngsook
name: Kim, Jongmin
name: Chong, Diana C.
name: Liu, Jiandong
name: Wylie, Lyndsay A.
name: Mouillesseaux, Kevin P.
name: Jin, Suk-Won
name: Bautch, Victoria L.
name: Saunders, Lauren M.
name: Samsa, Leigh Ann
name: Wiley, David S.
name: Kim, Jun-Dae
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Functional blood vessel growth depends on generation of distinct but coordinated responses from endothelial cells. Bone morphogenetic proteins (BMP), part of the TGFβ superfamily, bind receptors to induce phosphorylation and nuclear translocation of SMAD transcription factors (R-SMAD1/5/8) and regulate vessel growth. However, SMAD1/5/8 signalling results in both pro- and anti-angiogenic outputs, highlighting a poor understanding of the complexities of BMP signalling in the vasculature. Here we show that BMP6 and BMP2 ligands are pro-angiogenic in vitro and in vivo, and that lateral vessel branching requires threshold levels of R-SMAD phosphorylation. Endothelial cell responsiveness to these pro-angiogenic BMP ligands is regulated by Notch status and Notch sets responsiveness by regulating a cell-intrinsic BMP inhibitor, SMAD6, which affects BMP responses upstream of target gene expression. Thus, we reveal a paradigm for Notch-dependent regulation of angiogenesis: Notch regulates SMAD6 expression to affect BMP responsiveness of endothelial cells and new vessel branch formation.
title: A convenient category of locally stratified spaces
Creators: name: Nicotra, Stefano
Publisher: name: University of Liverpool Repository
Year: 2020

description: In this thesis we define the notion of a locally stratified space. Locally stratified spaces are particular kinds of streams and d-spaces which are locally modelled on stratified spaces. We construct a locally presentable and cartesian closed category of locally stratified spaces that admits an adjunction with the category of simplicial sets. Moreover, we show that the full subcategory spanned by locally stratified spaces whose associated simplicial set is an ∞-category has the structure of a category with fibrant objects. We define the fundamental category of a locally stratified space and show that the canonical functor θ_A from the fundamental category of a simplicial set A to the fundamental category of its realisation is essentially surjective. We show that the functor θ_A sends split monomorphisms to isomorphisms, in particular we show that θ_A is not necessarily an equivalence of categories. On the other hand, we show that the fundamental category of the realisation of the simplicial circle is equivalent to the monoid of the natural numbers. To conclude, we define left covers of locally stratified spaces and we show that, under suitable assumptions, the category of representations of the fundamental category of a simplicial set is equivalent to the category of left covers over its realisation.
Chaotic Information Processing by Extremal Black Holes
Creators: name: Axenides, Minos
name: Floratos, Emmanuel
name: Nicolis, Stam
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We review an explicit regularization of the AdS$_2$/CFT$_1$ correspondence, that preserves all isometries of bulk and boundary degrees of freedom. This scheme is useful to characterize the space of the unitary evolution operators that describe the dynamics of the microstates of extremal black holes in four spacetime dimensions. Using techniques from algebraic number theory to evaluate the transition amplitudes, we remark that the regularization scheme expresses the fast quantum computation capability of black holes as well as its chaotic nature.
description: 8 pages, 2 JPEG figues. Contribution to the VII Black Holes Workshop, Aveiro PT, Decemeber 2014
title: DIGIS: Digital Geochemistry Infrastructure for GEOROC 2.0
Creators: name:  Klöcking ,  Marthe
name:  Sarbas ,  Bärbel
name:  Horstmann ,  Wolfram
name:  Möller-McNett ,  Stefan
name:  Nieschulze ,  Jens
name:  Sporleder ,  Caroline
name:  Willbold ,  Matthias
name:  Wörner ,  Gerhard
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: GEOROC is a leading open-access source of geochemical and isotopic datasets and has facilitated thousands of peer-reviewed publications and new avenues of geochemical research. The new Digital Geochemistry Infrastructure (DIGIS) concept of GEOROC 2.0, an integral part of the NFDI4Earth initiative, will continue and enhance the existing data collection by generating a connected platform that meets future challenges of digital data-based research and provides advanced service to the community. Our approach is to (1) realign GEOROC with current and future demands in digital geochemical research, especially regarding FAIR (findable, accessible, interoperable, reusable) principles; (2) provide this service with future-ready, adaptable IT infrastructure; and (3) identify, develop and recommend good-practice rules for the curation of physical samples linked to the GEOROC 2.0 platform. DIGIS will implement an interoperable metadata model as well as data and metadata exchange via standardised application interfaces (APIs). The scientific development of GEOROC 2.0 and the re-organisation of its IT infrastructure will enable a more diverse range of geochemical data, improving integration in other research disciplines such as soil science, remote sensing, and archaeometry. The DIGIS concept for GEOROC 2.0 includes open access to end-to-end text and data mining, integration of IGSNs and data DOIs, multi-way data harvesting capabilities, and state-of-the-art connectivity to other databases. By ensuring continued open access to a FAIR database, DIGIS aims to facilitate sustainability in future Environmental and Earth Science research.
Cyathea andina Domin, Pteridophyta
Creators: name: Lehnert, Marcus
name: Kessler, Michael
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Cyatheales
Cyatheaceae
Cyathea
Cyathea andina

description: Cyathea andina (H.Karst.) Domin, Pteridophyta 263. 1929.
 Range: —Greater Antilles; Andes from Colombia to Bolivia (CO, LP).
 Ecology: —Uncommon in the understory of lower montane rainforests; 1150–1650 m.
 Notes:— Often confused with other species but easily recognized by the convex contour of the sides of pinnules and segments, the subentire to bluntly crenulate margins, and the concolorous petiole scales. Most similar in pinnule outline are C. cyatheoides (Desv.) K.U.Kramer and C. surinamensis Domin, both from the Guayana Shield and Amazonia mostly north of the Amazonas-Salimoes-river; a sterile and juvenile specimen from Bolivia (Cardenas 3002, F) may represent the latter species. See Lehnert (2011b) for a key to the species of this alliance.
description: Published as part of Lehnert, Marcus & Kessler, Michael, 2018, Prodromus of a fern flora for Bolivia. XX. Cyatheaceae, pp. 118-134 in Phytotaxa 334 (2) on page 125, DOI: 10.11646/phytotaxa.334.2.2, http://zenodo.org/record/13721436
Trend Assessment, Paardeberg, site 3419AC/2
Creators: name: Jonkershoek Forestry Research Center
Publisher: name: South African Environmental Observation Network
Year: 2022
Subjects: Jonkershoek Forestry Research Centre
Trend Assessment
Paardeberg

description: This is a scanned copy of a trend assessment, Paardeberg, site 3419AC/2, with photographs. The Jonkershoek Forestry Research Center (part of the former South African Forestry Research Institute) was established in 1935 at Jonkershoek, near Stellenbosch, under the directorship of Dr C. L. Wicht. The initial aim was to determine how forestry activities in state plantations would affect climate, water conservation and erosion, and was later expanded to include studies of fynbos ecology, fire and alien species. Studies from the 1930s to the early 1990s saw the accumulation of a large amount of data dealing with fire experiments, detailed vegetation plot surveys, rare plant surveys and ecological studies, hydrological studies and the development of management plans for catchments around the Western Cape. SAEON now houses the archive of data collected by the Jonkershoek Forestry Research Center, which was originally held by the Council for Scientific and Industrial Research (CSIR).
Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor
Creators: name: Di Paola, Jorge
name: Chen, Wenchun
name: Dragovich, Matthew A.
name: Syed, Anum K.
name: Doering, Christopher B.
name: Liang, Xin
name: Paul, David S.
name: Zakas, Philip
name: Ware, Jerry
name: Lanza, Francois
name: Xu, Yan
name: Berndt, Michael C.
name: Zhang, X. Frank
name: Li, Renhao
name: Bergmeier, Wolfgang
name: Deng, Wei
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Mechanisms by which blood cells sense shear stress are poorly characterized. In platelets, glycoprotein (GP)Ib–IX receptor complex has been long suggested to be a shear sensor and receptor. Recently, a relatively unstable and mechanosensitive domain in the GPIbα subunit of GPIb–IX was identified. Here we show that binding of its ligand, von Willebrand factor, under physiological shear stress induces unfolding of this mechanosensory domain (MSD) on the platelet surface. The unfolded MSD, particularly the juxtamembrane ‘Trigger' sequence therein, leads to intracellular signalling and rapid platelet clearance. These results illustrate the initial molecular event underlying platelet shear sensing and provide a mechanism linking GPIb–IX to platelet clearance. Our results have implications on the mechanism of platelet activation, and on the pathophysiology of von Willebrand disease and related thrombocytopenic disorders. The mechanosensation via receptor unfolding may be applicable for many other cell adhesion receptors.
Municipio di Firenze. Il Sindaco Ubaldino Peruzzi a Luigi Ridolfi (12 giugno 1872)
Creators: name: Peruzzi, Ubaldino
name: Ridolfi, Luigi
Publisher: name: Zenodo
Year: 2023
Subjects: Accademia dei Georgofili
Peruzzi, Ubaldino
Ridolfi, Luigi
Lettera
Letter
Carteggio
Correspondence
1872

description: Lettera di Ubaldino Peruzzi a Luigi Ridolfi del 12 giugno 1872. Segnatura dell’unità documentale: Archivio storico dell’Accademia dei Georgofili, Carteggio, Busta 36, 4725. Natura: manoscritto. Consistenza: cc. 2
description: Digitalizzato come parte della Mostra virtuale: Ubaldino Peruzzi : un percorso in rete : in occasione del bicentenario della nascita https://www.georgofili.it/contenuti/ubaldino-peruzzi-un-percorso-in-rete/17485
Non-linear energy conservation theorem in the framework of Special Relativity
Creators: name: Teruel, Ginés R. Pérez
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this work we revisit the study of the gravitational interaction in the context of the Special Theory of Relativity. It is found that, as long as the equivalence principle is respected, a relativistic non-linear energy conservation theorem arises in a natural way. We interpret that this non-linear conservation law stresses the non-linear character of the gravitational interaction.The theorem reproduces the energy conservation theorem of Newtonian mechanics in the corresponding low energy limit, but also allows to derive some standard results of post-Newtonian gravity, such as the formula of the gravitational redshift. Guided by this conservation law, we develop a Lagrangian formalism for a particle in a gravitational field. We realize that the Lagrangian can be written in an explicit covariant fashion, and turns out to be the geodesic Lagrangian of a curved Lorentzian manifold. Therefore, any attempt to describe gravity within the Special Theory, leads outside their own domains towards a curved space-time. Thus, the pedagogical content of the paper may be useful as a starting point to discuss the problem of Gravitation in the context of the Special Theory, as a preliminary step before introducing General Relativity.
PolyMetformin combines carrier and anticancer activities for in vivo siRNA delivery
Creators: name: Xiong, Yang
name: Huang, Leaf
name: Zhao, Yi
name: Wang, Yuhua
name: Guo, Shutao
name: Wang, Wei
name: Miao, Lei
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Metformin, a widely implemented anti-diabetic drug, exhibits potent anticancer efficacies. Herein a polymeric construction of Metformin, PolyMetformin (PolyMet) is successfully synthesized through conjugation of linear polyethylenimine (PEI) with dicyandiamide. The delocalization of cationic charges in the biguanide groups of PolyMet reduces the toxicity of PEI both in vitro and in vivo. Furthermore, the polycationic properties of PolyMet permits capture of siRNA into a core-membrane structured lipid-polycation-hyaluronic acid (LPH) nanoparticle for systemic gene delivery. Advances herein permit LPH-PolyMet nanoparticles to facilitate VEGF siRNA delivery for VEGF knockdown in a human lung cancer xenograft, leading to enhanced tumour suppressive efficacy. Even in the absence of RNAi, LPH-PolyMet nanoparticles act similarly to Metformin and induce antitumour efficacy through activation of the AMPK and inhibition of the mTOR. In essence, PolyMet successfully combines the intrinsic anticancer efficacy of Metformin with the capacity to carry siRNA to enhance the therapeutic activity of an anticancer gene therapy.
The centralized originality check of the doctoral dissertations at the University of Belgrade: a model of a controlled and transparent procedure
Creators: name: Stolic, Dragana
name: Markovic, Vladimir
Publisher: name: Zenodo
Year: 2022

description: The procedure of originality check of the doctoral dissertations at the University in Belgrade, established in 2018 is presented in this paper. Since that year, at the University of Belgrade, the service Ithenticate (Turnitin) is used systematically for originality checks for all Ph.D. thesis that are in the process of evaluation. This presentation intends to explain how the procedure can be maximally controlled on one side but also transparent enough on the other.
Triangular Alignment (TAME): A Tensor-based Approach for Higher-order Network Alignment
Creators: name: Mohammadi, Shahin
name: Gleich, David
name: Kolda, Tamara
name: Grama, Ananth
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computational Engineering, Finance, and Science (cs.CE)
subject: FOS: Computer and information sciences

description: Network alignment has extensive applications in comparative interactomics. Traditional approaches aim to simultaneously maximize the number of conserved edges and the underlying similarity of aligned entities. We propose a novel formulation of the network alignment problem that extends topological similarity to higher-order structures and provides a new objective function that maximizes the number of aligned substructures. This objective function corresponds to an integer programming problem, which is NP-hard. Consequently, we identify a closely related surrogate function whose maximization results in a tensor eigenvector problem. Based on this formulation, we present an algorithm called Triangular AlignMEnt (TAME), which attempts to maximize the number of aligned triangles across networks. Using a case study on the NAPAbench dataset, we show that triangular alignment is capable of producing mappings with high node correctness. We further evaluate our method by aligning yeast and human interactomes. Our results indicate that TAME outperforms the state-of-art alignment methods in terms of conserved triangles. In addition, we show that the number of conserved triangles is more significantly correlated, compared to the conserved edge, with node correctness and co-expression of edges. Our formulation and resulting algorithms can be easily extended to arbitrary motifs.
description: Submitted to the IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB) for review
Programming temporal shapeshifting
Creators: name: Hu, Xiaobo
name: Sheiko, Sergei S.
name: Daniel, William F. M.
name: Dobrynin, Andrey V.
name: Li, Qiaoxi
name: Zhushma, Aleksandr P.
name: Vatankhah-Varnosfaderani, Mohammad
name: Zhou, Jing
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Shapeshifting enables a wide range of engineering and biomedical applications, but until now transformations have required external triggers. This prerequisite limits viability in closed or inert systems and puts forward the challenge of developing materials with intrinsically encoded shape evolution. Herein we demonstrate programmable shape-memory materials that perform a sequence of encoded actuations under constant environment conditions without using an external trigger. We employ dual network hydrogels: in the first network, covalent crosslinks are introduced for elastic energy storage, and in the second one, temporary hydrogen-bonds regulate the energy release rate. Through strain-induced and time-dependent reorganization of the reversible hydrogen-bonds, this dual network allows for encoding both the rate and pathway of shape transformations on timescales from seconds to hours. This generic mechanism for programming trigger-free shapeshifting opens new ways to design autonomous actuators, drug-release systems and active implants.
Trend Assessment of Marloth Nature Reserve, Swellendam, Langeberg, site 3320CD/1
Creators: name: Jonkershoek Forestry Research Center
Publisher: name: South African Environmental Observation Network
Year: 2022
Subjects: Jonkershoek Forestry Research Centre
trend assessment
map
Marloth Nature Reserve
Langeberg
Swellendam

description: This is a scanned copy of a trend assessment with a map, diagram and photographs, of Marloth Nature Reserve, Swellendam, Langeberg, site 3320CD/1. The Jonkershoek Forestry Research Center (part of the former South African Forestry Research Institute) was established in 1935 at Jonkershoek, near Stellenbosch, under the directorship of Dr C. L. Wicht. The initial aim was to determine how forestry activities in state plantations would affect climate, water conservation and erosion, and was later expanded to include studies of fynbos ecology, fire and alien species. Studies from the 1930s to the early 1990s saw the accumulation of a large amount of data dealing with fire experiments, detailed vegetation plot surveys, rare plant surveys and ecological studies, hydrological studies and the development of management plans for catchments around the Western Cape. SAEON now houses the archive of data collected by the Jonkershoek Forestry Research Center, which was originally held by the Council for Scientific and Industrial Research (CSIR).
Cyathea arnecornelii Lehnert, Amer. Fern J.
Creators: name: Lehnert, Marcus
name: Kessler, Michael
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Cyatheales
Cyatheaceae
Cyathea
Cyathea arnecornelii

description: Cyathea arnecornelii Lehnert, Amer. Fern J. 93(4): 178. 2003.
 Range: — Peru, Bolivia (LP).
 Ecology: —Uncommon in ridge top vegetation and open spots in elfin forests with daily mists, relatively rare; 2580–3000 m.
 Notes: —Easily recognized in the field by the protruding trunk apex covered in grayish scales.
description: Published as part of Lehnert, Marcus & Kessler, Michael, 2018, Prodromus of a fern flora for Bolivia. XX. Cyatheaceae, pp. 118-134 in Phytotaxa 334 (2) on page 125, DOI: 10.11646/phytotaxa.334.2.2, http://zenodo.org/record/13721436
Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable
Creators: name: Butler, Thomas C.
name: Walker, Bruce D.
name: Goonetilleke, Nilu
name: Chakraborty, Arup K.
name: McMichael, Andrew J.
name: Barton, John P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Human immunodeficiency virus (HIV) evolves within infected persons to escape being destroyed by the host immune system, thereby preventing effective immune control of infection. Here, we combine methods from evolutionary dynamics and statistical physics to simulate in vivo HIV sequence evolution, predicting the relative rate of escape and the location of escape mutations in response to T-cell-mediated immune pressure in a cohort of 17 persons with acute HIV infection. Predicted and clinically observed times to escape immune responses agree well, and we show that the mutational pathways to escape depend on the viral sequence background due to epistatic interactions. The ability to predict escape pathways and the duration over which control is maintained by specific immune responses open the door to rational design of immunotherapeutic strategies that might enable long-term control of HIV infection. Our approach enables intra-host evolution of a human pathogen to be predicted in a probabilistic framework.
Strings of droplets propelled by coherent waves
Creators: name: Filoux, B.
name: Hubert, M.
name: Vandewalle, N.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Bouncing walking droplets possess fascinating properties due to their peculiar wave/particule interaction. In order to study such walkers in a 1d system, we considered the case of one or more droplets in an annular cavity. We show that, in this geometry, walking droplets form a string of synchronized bouncing droplets that share a common coherent wave propelling the group at a speed faster than single walkers. The formation of this coherent wave and the collective behavior of droplets is captured by a model.
description: 5 Pages, 5 Figures, 2 supplementary movies (identical), supplementary .pdf file
Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator
Creators: name: Starmer, Joshua
name: Conley, Bridget
name: Martin, Aaron
name: Wilson, Elizabeth M.
name: Free, Meghan
name: Bakhru, Pearl
name: Su, Maureen A.
name: Nelson, Jennifer S.
name: Zhu, Meng-Lei
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Male gender is protective against multiple sclerosis and other T-cell-mediated autoimmune diseases. This protection may be due, in part, to higher androgen levels in males. Androgen binds to the androgen receptor (AR) to regulate gene expression, but how androgen protects against autoimmunity is not well understood. Autoimmune regulator (Aire) prevents autoimmunity by promoting self-antigen expression in medullary thymic epithelial cells, such that developing T cells that recognize these self-antigens within the thymus undergo clonal deletion. Here we show that androgen upregulates Aire-mediated thymic tolerance to protect against autoimmunity. Androgen recruits AR to Aire promoter regions, with consequent enhancement of Aire transcription. In mice and humans, thymic Aire expression is higher in males compared with females. Androgen administration and male gender protect against autoimmunity in a multiple sclerosis mouse model in an Aire-dependent manner. Thus, androgen control of an intrathymic Aire-mediated tolerance mechanism contributes to gender differences in autoimmunity.
Prototype Substation Design: A Thesis Report on Designing a Low Budget Substation in Bangladesh
Creators: name: Sharif, Md Maskat
name: Chowdhury, Avijit
name: Zaman, Mostafa Ibna
name: Uddin, Md. Sharfag
name: Hosen, Shakhawat
name: Jabed, Abdullah Al
name: Hossain, Mohammad Shahadat
Publisher: name: Zenodo
Year: 2022
Subjects: General arrangement, Microcontroller, Controlling device, Electrical Protective devices, Arduino UNO, Programming

description: The electrical power system used today is a.c. i.e. alternating current is used to produce, transmit, and distribute electricity. Through a vast network of transmission and distribution, the electric power is at convenient locations, typically far away.
 It may be essential and desired to alter certain electric supply properties (such as voltage, AC to DC conversion, frequency, and power factor, among others) at various points along the power system's line. A suitable piece of equipment called a substation carries out this function. The substation is the collection of equipment utilized for this. Similar to this, the voltage may need to be stepped down to the utilization level close to the consumer's locations. Once more, a suited tool called a substation handles this task. Designing a substation and demonstrating the functionality of the major and secondary distribution systems are the primary goals of this project. Step up and step down, substation metering, load balancing, safety, and power quality were the main areas of concentration. We used an Arduino Board, a flame sensor, transformers, various sorts of sensors, an LED bulb as a load, electronic switches, an LCD display, a potentiometer, and other things in this project. We used the C++ programming language to carry out this project and simulated it on Proteus. This prototype substation has the capacity to alter the voltage and other properties of the electrical energy passing through it, as well as to interrupt or create an electrical circuit. This project will describe the various equipment used in substations as well as their uses and functions. A system based on hardware has been created, and it has proven that the system is effective.
description: {"references": ["Di Jasio, Willmshurst, Ibrahim, Morton, Bates, J. Smith, D.W. Smith, Hellebuyck, \"PIC Microcontrollers- Know it all \"(2nd Edition), NEWSEN Publication (Page12-23)"]}
Cyathea bettinae Lehnert, Brittonia
Creators: name: Lehnert, Marcus
name: Kessler, Michael
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Cyatheales
Cyatheaceae
Cyathea
Cyathea bettinae

description: Cyathea bettinae Lehnert, Brittonia 56: 210. 2004
 Range: —Endemic to Bolivia (LP).
 Ecology: —Rare on ridges and secondary vegetation in cloud forests; 2950 m.
 Notes: —This species has been collected only twice at the same location.
description: Published as part of Lehnert, Marcus & Kessler, Michael, 2018, Prodromus of a fern flora for Bolivia. XX. Cyatheaceae, pp. 118-134 in Phytotaxa 334 (2) on page 125, DOI: 10.11646/phytotaxa.334.2.2, http://zenodo.org/record/13721436
Small nucleoli are a cellular hallmark of longevity
Creators: name: Partridge, Linda
name: Antebi, Adam
name: Späth, Martin
name: Slagboom, P. Eline
name: Liu, Wei
name: Jain, Chirag
name: Nakamura, Shuhei
name: Raz, Yotam
name: Müller, Roman-Ulrich
name: Heestand, Bree
name: Tiku, Varnesh
name: Suchiman, H. Eka. D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Animal lifespan is regulated by conserved metabolic signalling pathways and specific transcription factors, but whether these pathways affect common downstream mechanisms remains largely elusive. Here we show that NCL-1/TRIM2/Brat tumour suppressor extends lifespan and limits nucleolar size in the major C. elegans longevity pathways, as part of a convergent mechanism focused on the nucleolus. Long-lived animals representing distinct longevity pathways exhibit small nucleoli, and decreased expression of rRNA, ribosomal proteins, and the nucleolar protein fibrillarin, dependent on NCL-1. Knockdown of fibrillarin also reduces nucleolar size and extends lifespan. Among wildtype C. elegans, individual nucleolar size varies, but is highly predictive for longevity. Long-lived dietary restricted fruit flies and insulin-like-peptide mutants exhibit small nucleoli and fibrillarin expression, as do long-lived dietary restricted and IRS1 knockout mice. Furthermore, human muscle biopsies from individuals who underwent modest dietary restriction coupled with exercise also display small nucleoli. We suggest that small nucleoli are a cellular hallmark of longevity and metabolic health conserved across taxa.
Seed collection/germination of Leucadendron pubescens and Paranomus bracteolaris at site 3219AC/gen
Creators: name: Jonkershoek Forestry Research Center
Publisher: name: South African Environmental Observation Network
Year: 2022
Subjects: Jonkershoek Forestry Research Centre
seed collection
seed germination
Leucadendron pubescens
Paranomus bracteolaris

description: This is a scanned copy of a document noting the seed collection/germination of Leucadendron pubescens and Paranomus bracteolaris at site 3219AC/gen. The Jonkershoek Forestry Research Center (part of the former South African Forestry Research Institute) was established in 1935 at Jonkershoek, near Stellenbosch, under the directorship of Dr C. L. Wicht. The initial aim was to determine how forestry activities in state plantations would affect climate, water conservation and erosion, and was later expanded to include studies of fynbos ecology, fire and alien species. Studies from the 1930s to the early 1990s saw the accumulation of a large amount of data dealing with fire experiments, detailed vegetation plot surveys, rare plant surveys and ecological studies, hydrological studies and the development of management plans for catchments around the Western Cape. SAEON now houses the archive of data collected by the Jonkershoek Forestry Research Center, which was originally held by the Council for Scientific and Industrial Research (CSIR).
SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding
Creators: name: Lee, Jae Ho
name: Kim, Jae Bum
name: Lee, Gha Young
name: Titchenell, Paul
name: Birnbaum, Morris J.
name: Xu, Aimin
name: Jang, Hagoon
name: Cheng, Kenneth King Yip
name: Selby, Christopher P.
name: Lee, Gung
name: Sancar, Aziz
name: Jeon, Yong Geun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: SREBP1c is a key lipogenic transcription factor activated by insulin in the postprandial state. Although SREBP1c appears to be involved in suppression of hepatic gluconeogenesis, the molecular mechanism is not thoroughly understood. Here we show that CRY1 is activated by insulin-induced SREBP1c and decreases hepatic gluconeogenesis through FOXO1 degradation, at least, at specific circadian time points. SREBP1c−/− and CRY1−/− mice show higher blood glucose than wild-type (WT) mice in pyruvate tolerance tests, accompanied with enhanced expression of PEPCK and G6Pase genes. CRY1 promotes degradation of nuclear FOXO1 by promoting its binding to the ubiquitin E3 ligase MDM2. Although SREBP1c fails to upregulate CRY1 expression in db/db mice, overexpression of CRY1 attenuates hyperglycaemia through reduction of hepatic FOXO1 protein and gluconeogenic gene expression. These data suggest that insulin-activated SREBP1c downregulates gluconeogenesis through CRY1-mediated FOXO1 degradation and that dysregulation of hepatic SREBP1c-CRY1 signalling may contribute to hyperglycaemia in diabetic animals.
Cyathea carolihenrici Lehnert, Amer. Fern J.
Creators: name: Lehnert, Marcus
name: Kessler, Michael
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Cyatheales
Cyatheaceae
Cyathea
Cyathea carolihenrici

description: Cyathea carolihenrici Lehnert, Amer. Fern J. 93: 180. 2003.
 Range: — Peru, Bolivia (LP).
 Ecology: —Rare in cloud forest and elfin forests, mature plants often part of the canopy; 2750–3100 m.
 Notes: —Similar and undoubtedly most closely related to C. meridensis H.Karst. from the northern Andes. On average, Cyathea carolihenrici has thicker trunks with fronds scars arranged in clear horizontal bands (less obviously so or spirally in C. meridensis) and has darker laminar squamules (dark brown to castaneous vs. yellowish). Also similar is C. lindeniana C.Presl, but that species has sparser yet more clearly recognizable scurf squamellae (erect, flat, small lanceolate squamules, dark orange-brown vs. dense pulverulent scurf of appressed, dissected castaneous squamellae in C. carolihenrici and C. meridensis). The ranges of these species all overlap in Peru, and they may all be present in Bolivia. See Lehnert (2009a) for further discussion.
description: Published as part of Lehnert, Marcus & Kessler, Michael, 2018, Prodromus of a fern flora for Bolivia. XX. Cyatheaceae, pp. 118-134 in Phytotaxa 334 (2) on pages 125-126, DOI: 10.11646/phytotaxa.334.2.2, http://zenodo.org/record/13721436
Trend Assessment of Marloth Nature Reserve, Swellendam, Langeberg, site 3320CD/1
Creators: name: Jonkershoek Forestry Research Center
Publisher: name: South African Environmental Observation Network
Year: 2022
Subjects: Jonkershoek Forestry Research Centre
trend assessment
map
Langeberg
Swellendam
Marloth Nature Reserve

description: This is a scanned copy of a trend assessment with a map, diagrams and photographs of Marloth Nature Reserve, Swellendam, Langeberg, site 3320CD/1. The Jonkershoek Forestry Research Center (part of the former South African Forestry Research Institute) was established in 1935 at Jonkershoek, near Stellenbosch, under the directorship of Dr C. L. Wicht. The initial aim was to determine how forestry activities in state plantations would affect climate, water conservation and erosion, and was later expanded to include studies of fynbos ecology, fire and alien species. Studies from the 1930s to the early 1990s saw the accumulation of a large amount of data dealing with fire experiments, detailed vegetation plot surveys, rare plant surveys and ecological studies, hydrological studies and the development of management plans for catchments around the Western Cape. SAEON now houses the archive of data collected by the Jonkershoek Forestry Research Center, which was originally held by the Council for Scientific and Industrial Research (CSIR).
Structural characterization of antibiotic self-immunity tRNA synthetase in plant tumour biocontrol agent
Creators: name: Temple, Brenda R.
name: Palencia, Andrés
name: Chopra, Shaileja
name: Reader, John
name: Cusack, Stephen
name: Virus, Cornelia
name: Schulwitz, Sarah
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Antibiotic-producing microbes evolved self-resistance mechanisms to avoid suicide. The biocontrol Agrobacterium radiobacter K84 secretes the Trojan Horse antibiotic agrocin 84 that is selectively transported into the plant pathogen A. tumefaciens and processed into the toxin TM84. We previously showed that TM84 employs a unique tRNA-dependent mechanism to inhibit leucyl-tRNA synthetase (LeuRS), while the TM84-producer prevents self-poisoning by expressing a resistant LeuRS AgnB2. We now identify a mechanism by which the antibiotic-producing microbe resists its own toxin. Using a combination of structural, biochemical and biophysical approaches, we show that AgnB2 evolved structural changes so as to resist the antibiotic by eliminating the tRNA-dependence of TM84 binding. Mutagenesis of key resistance determinants results in mutants adopting an antibiotic-sensitive phenotype. This study illuminates the evolution of resistance in self-immunity genes and provides mechanistic insights into a fascinating tRNA-dependent antibiotic with applications for the development of anti-infectives and the prevention of biocontrol emasculation.
The genetic regulatory signature of type 2 diabetes in human skeletal muscle
Creators: name: Chines, Peter S.
name: Vadlamudi, Swarooparani
name: Didion, John P.
name: Crawford, Gregory E.
name: Parker, Stephen C. J.
name: Welch, Ryan P.
name: Tuomilehto, Jaakko
name: Lakka, Timo A.
name: Wen, Xiaoquan
name: Scott, Laura J.
name: Sundvall, Jouko
name: Collins, Francis S.
name: Kiseleva, Anna
name: Narisu, Narisu
name: Laakso, Markku
name: Koistinen, Heikki A.
name: Wolford, Brooke N.
name: Jiang, Hui
name: Huyghe, Jeroen R.
name: Albanus, Ricardo D'Oliveira
name: Beck, Andrew T.
name: Kinnunen, Leena
name: Erdos, Michael R.
name: Boehnke, Michael
name: Mohlke, Karen L.
name: Bonnycastle, Lori L.
name: Stringham, Heather M.
name: Watanabe, Richard M.
name: Saramies, Jouko
name: Jackson, Anne U.
name: Taylor, D. Leland
name: Hensley, John
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Type 2 diabetes (T2D) results from the combined effects of genetic and environmental factors on multiple tissues over time. Of the >100 variants associated with T2D and related traits in genome-wide association studies (GWAS), >90% occur in non-coding regions, suggesting a strong regulatory component to T2D risk. Here to understand how T2D status, metabolic traits and genetic variation influence gene expression, we analyse skeletal muscle biopsies from 271 well-phenotyped Finnish participants with glucose tolerance ranging from normal to newly diagnosed T2D. We perform high-depth strand-specific mRNA-sequencing and dense genotyping. Computational integration of these data with epigenome data, including ATAC-seq on skeletal muscle, and transcriptome data across diverse tissues reveals that the tissue-specific genetic regulatory architecture of skeletal muscle is highly enriched in muscle stretch/super enhancers, including some that overlap T2D GWAS variants. In one such example, T2D risk alleles residing in a muscle stretch/super enhancer are linked to increased expression and alternative splicing of muscle-specific isoforms of ANK1.
The radial profile and flattening of the Milky Way's stellar halo to $\rm 80~$kpc from the SEGUE K-giant Survey
Creators: name: Xue, Xiang-Xiang
name: Rix, Hans-Walter
name: Ma, Zhibo
name: Morrison, Heather
name: Bovy, Jo
name: Sesar, Branimir
name: Janesh, William
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We characterise the radial density, metallicity and flattening profile of the Milky Way's stellar halo, based on the large sample of 1757 spectroscopically confirmed giant stars from SDSS/SEGUE-2 after excising stars that were algorithmically attributed to apparent halo substructure (including the Sagittarius stream). Compared to BHB stars or RR Lyrae, giants are more readily understood tracers of the overall halo star population, with less bias in age or metallicity. The well-characterized selection function of the sample enables forward modelling of those data, based on ellipsoidal stellar density models, $ν_* (R,z)$, with Einasto profiles and (broken) power laws for their radial dependence, combined with a model for the metallicity gradient and the flattening profile. Among models with constant flattening, these data are reasonably well fit by an Einasto profile of $n=3.1\pm 0.5$ with an effective radius $\rm r_{eff} = 15\pm2~$kpc and a flattening of $q=0.7\pm 0.02$; or comparably well by an equally flattened broken power-law, with radial slopes of $α_{in}=2.1\pm 0.3$ and $α_{out}=3.8\pm 0.1$, with a break-radius of $r_{break}=18\pm1$~kpc; this is largely consistent with earlier work. We find a modest, but significant metallicity gradient within the "outer" stellar halo, $\rm [Fe/H]$ decreasing outward. If we allow for a variable flattening $q = f(r_{GC} )$, we find the distribution of halo giants to be considerably more flattened at small radii, $q({\rm 10~kpc})\sim 0.57$, compared to $q(>30{\rm kpc})\sim 0.8$. Remarkably, the data are then very well fit by a single power-law of index $\rm \sim 4.2\pm0.1$ of the variable $r_q\equiv\sqrt{R^2+(z/q(r))^2}$. In this simple and better fitting model, there is a break in flattening at $\sim 20$~kpc, instead of a break in the radial density function.
description: accepted by ApJ. Final version
Cyathea catacampta Alston, J. Wash. Acad. Sci.
Creators: name: Lehnert, Marcus
name: Kessler, Michael
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Cyatheales
Cyatheaceae
Cyathea
Cyathea catacampta

description: Cyathea catacampta Alston, J. Wash. Acad. Sci. 48: 231. 1958.
 Range: —Andes from Colombia to Bolivia (LP).
 Ecology: —Rare at higher elevations in montane rainforests; 2400–2850 m.
 Notes: —Similar and closely related to C. squamipes H.Karst. Both species often grow together; in direct comparison C. catacampta can be distinguished by having relatively long and wide, downwardly curved fronds on short petioles with ± sessile pinnae while the fronds of C. squamipes are held patent-arching, with the lower pinnae visibly stalked. Cyathea frondosa H.Karst., a regular species of high elevations in the northern Andes, may also occur scatteredly in Peru and Bolivia. It differs from C. catacampta in denser, finer scurf of pale brown to rarely whitish color, ± concolorous brown petiole scales that have a twisted apex, and presence of remote basal pinnae. See Lehnert (2009a) for further discussion of these species.
description: Published as part of Lehnert, Marcus & Kessler, Michael, 2018, Prodromus of a fern flora for Bolivia. XX. Cyatheaceae, pp. 118-134 in Phytotaxa 334 (2) on page 126, DOI: 10.11646/phytotaxa.334.2.2, http://zenodo.org/record/13721436
Therapeutically engineered induced neural stem cells are tumour-homing and inhibit progression of glioblastoma
Creators: name: Hingtgen, Shawn D.
name: Baldwin, Albert S.
name: Magness, Scott T.
name: Miller, C. Ryan
name: Bagó, Juli R.
name: Okolie, Onyi
name: Alfonso-Pecchio, Adolfo
name: Dumitru, Raluca
name: Rinkenbaugh, Amanda
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Transdifferentiation (TD) is a recent advancement in somatic cell reprogramming. The direct conversion of TD eliminates the pluripotent intermediate state to create cells that are ideal for personalized cell therapy. Here we provide evidence that TD-derived induced neural stem cells (iNSCs) are an efficacious therapeutic strategy for brain cancer. We find that iNSCs genetically engineered with optical reporters and tumouricidal gene products retain the capacity to differentiate and induced apoptosis in co-cultured human glioblastoma cells. Time-lapse imaging shows that iNSCs are tumouritropic, homing rapidly to co-cultured glioblastoma cells and migrating extensively to distant tumour foci in the murine brain. Multimodality imaging reveals that iNSC delivery of the anticancer molecule TRAIL decreases the growth of established solid and diffuse patient-derived orthotopic glioblastoma xenografts 230- and 20-fold, respectively, while significantly prolonging the median mouse survival. These findings establish a strategy for creating autologous cell-based therapies to treat patients with aggressive forms of brain cancer.