title: Ð Ð¾Ð»Ñ WNT ÑÐ¸Ð³Ð½Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ ÐºÐ°ÑÐºÐ°Ð´Ð° Ð¸ PKA Ð² ÑÐµÐ³ÑÐ»ÑÑÐ¸Ð¸ Ð°Ð±ÐµÑÑÐ°Ð½ÑÐ½Ð¾Ð³Ð¾ Ð½ÐµÐ¹ÑÐ¾Ð³ÐµÐ½ÐµÐ·Ð° Ñ ÐºÑÑÑ Ð»Ð¸Ð½Ð¸Ð¸ ÐÑÑÑÐ¸Ð½ÑÐºÐ¾Ð³Ð¾-ÐÐ¾Ð»Ð¾Ð´ÐºÐ¸Ð½Ð¾Ð¹
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: The role of the WNT signaling cascade and PKA in the regulation of aberrant neurogenesis in Krushinsky-Molodkina rats
Creators: name: ÐÐ¸ÑÐ°Ð¹Ð»Ð¾Ð²Ð°, ÐÐ»Ð¸Ð·Ð°Ð²ÐµÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: Ð°Ð±ÐµÑÑÐ°Ð½ÑÐ½ÑÐ¹ Ð½ÐµÐ¹ÑÐ¾Ð³ÐµÐ½ÐµÐ·
ÑÐ¸Ð³Ð½Ð°Ð»ÑÐ½ÑÐ¹ Ð¿ÑÑÑ
ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ñ
Ð¼Ð¾Ð´ÐµÐ»Ñ Ð°ÑÐ´Ð¸Ð¾Ð³ÐµÐ½Ð½Ð¾Ð³Ð¾ ÐºÐ¸Ð½Ð´Ð»Ð¸Ð½Ð³Ð°
ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ñ Ð±ÐµÐ»ÐºÐ¾Ð²
aberrant neurogenesis
signaling pathway
epilepsy
audiogenic kindling model
protein expression

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ ÑÐ¸Ð³Ð½Ð°Ð»ÑÐ½ÑÑ ÐºÐ°ÑÐºÐ°Ð´Ð¾Ð² Ð½Ð° Ð¼Ð¾Ð´ÐµÐ»Ð¸ ÐºÐ¸Ð½Ð´Ð»Ð¸Ð½Ð³Ð°, ÐºÐ¾ÑÐ¾ÑÑÐµ ÑÐµÐ³ÑÐ»Ð¸ÑÑÑÑ Ð½ÐµÐ¹ÑÐ¾Ð³ÐµÐ½ÐµÐ· Ð¸ Ð¼Ð¾Ð³ÑÑ Ð¿ÑÐ¸Ð²ÐµÑÑÐ¸ Ðº ÑÑÐ¸Ð»ÐµÐ½Ð¸Ñ ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¸ Ð°Ð±ÐµÑÑÐ°Ð½ÑÐ½Ð¾Ð¼Ñ Ð½ÐµÐ¹ÑÐ¾Ð³ÐµÐ½ÐµÐ·Ñ. ÐÐ»Ñ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ñ ÑÑÐ¾Ð²Ð½Ñ ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸Ñ Ð¸Ð½ÑÐµÑÐµÑÑÐµÐ¼ÑÑ Ð±ÐµÐ»ÐºÐ¾Ð² Ð² WNT Ð¸ PKA ÑÐ¸Ð³Ð½Ð°Ð»ÑÐ½ÑÑ Ð¿ÑÑÑÑ Ð±ÑÐ»Ð¾ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¾ Ð´Ð²Ð° Ð¼ÐµÑÐ¾Ð´Ð°: Ð²ÐµÑÑÐµÑÐ½-Ð±Ð»Ð¾Ñ Ð¸ Ð¸Ð¼Ð¼ÑÐ½Ð¾Ð³Ð¸ÑÑÐ¾ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ¸Ð¹ Ð°Ð½Ð°Ð»Ð¸Ð·. Ð ÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐ²Ð¸Ð´ÐµÑÐµÐ»ÑÑÑÐ²ÑÑÑ Ð¾ ÑÐ¾Ð¼, ÑÑÐ¾ ÑÑÐ´Ð¾ÑÐ¾Ð¶Ð½Ð°Ñ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ Ð¿ÑÐ¸Ð²Ð¾Ð´Ð¸Ñ Ðº Ð°ÐºÑÐ¸Ð²Ð°ÑÐ¸Ð¸ ÐºÐ°Ðº WNT ÑÐ¸Ð³Ð½Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ ÐºÐ°ÑÐºÐ°Ð´Ð°, ÑÐ°Ðº Ð¸ PKA. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ Ð´Ð°Ð½Ð½ÑÐµ Ð¼Ð¾Ð³ÑÑ Ð±ÑÑÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ñ Ð² Ð´Ð°Ð»ÑÐ½ÐµÐ¹ÑÐµÐ¼ Ð°Ð½Ð°Ð»Ð¸Ð·Ðµ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ Ð±ÐµÐ»ÐºÐ¾Ð², ÑÑÐ°ÑÑÐ²ÑÑÑÐ¸Ñ Ð² ÑÐ¸Ð³Ð½Ð°Ð»ÑÐ½ÑÑ Ð¿ÑÑÑÑ, ÑÑÐ¾ Ð¿Ð¾Ð¼Ð¾Ð¶ÐµÑ Ð²ÑÑÑÐ½Ð¸ÑÑ Ð¼ÐµÑÐ°Ð½Ð¸Ð·Ð¼Ñ Ð°Ð±ÐµÑÑÐ°Ð½ÑÐ½Ð¾Ð³Ð¾ Ð½ÐµÐ¹ÑÐ¾Ð³ÐµÐ½ÐµÐ·Ð°. ÐÐ·ÑÑÐµÐ½Ð¸Ðµ Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½ÑÑ Ð¼ÐµÑÐ°Ð½Ð¸Ð·Ð¼Ð¾Ð² Ð¿ÑÐ¸Ð¿Ð°Ð´ÐºÐ¾Ð² Ð¼Ð¾Ð¶ÐµÑ Ð´Ð°ÑÑ Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ð¸Ðµ Ð¾Ð± Ð¾Ð±ÑÐ¸Ñ ÑÑÐ½ÐºÑÐ¸ÑÑ Ð¼Ð¾Ð·Ð³Ð°, Ð° Ð¼Ð¾Ð´ÐµÐ»Ð¸ ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ð¸ Ð½Ð° Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑ Ð±ÑÐ´ÑÑ Ð¿ÑÐ¾Ð´Ð¾Ð»Ð¶Ð°ÑÑ ÑÐ¿Ð¾ÑÐ¾Ð±ÑÑÐ²Ð¾Ð²Ð°ÑÑ Ð¿ÑÐ¾Ð³ÑÐµÑÑÑ ÐºÐ°Ðº Ð² Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸ÑÑ ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ð¸, ÑÐ°Ðº Ð¸ Ð² Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸ÑÑ Ð½ÐµÐ¹ÑÐ¾ÑÐ¸Ð·Ð¸Ð¾Ð»Ð¾Ð³Ð¸Ð¸, ÑÑÐ¾ Ð¿Ð¾Ð·Ð²Ð¾Ð»Ð¸Ñ Ð½Ð°Ð¹ÑÐ¸ Ð½Ð¾Ð²ÑÐµ Ð¿Ð¾Ð´ÑÐ¾Ð´Ñ Ð² Ð»ÐµÑÐµÐ½Ð¸Ðµ ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ð¸ Ð¸ Ð² Ð±ÑÐ´ÑÑÐµÐ¼ ÐºÑÐ¿Ð¸ÑÐ¾Ð²Ð°ÑÑ Ð°Ð±ÐµÑÑÐ°Ð½ÑÐ½ÑÐ¹ Ð½ÐµÐ¹ÑÐ¾Ð³ÐµÐ½ÐµÐ·.
description: The given work is devoted to the study of various signaling on the kindling model, which regulate neurogenesis and can lead to increased epileptic activity and aberrant neurogenesis. Two methods were used to determine the level of the proteins of interest in the WNT and PKA signaling pathways: Western blot and immunohistochemical analysis. The results of the study indicate that convulsive activity leads to activation of both the WNT signaling cascade and the PKA. The data obtained can be used in further analysis of various proteins involved in signaling pathways, which will help to clarify the mechanisms of aberrant neurogenesis. The study of the molecular mechanisms of seizures can provide insight into the general functions of the brain, and animal models of epilepsy will continue to contribute to progress in both epilepsy research and neurophysiology research, this will allow new approaches to the treatment of epilepsy and in the future to stop aberrant neurogenesis.