title: Ð¤Ð¸Ð»Ð¾Ð³ÐµÐ½ÐµÑÐ¸ÑÐµÑÐºÐ¸Ð¹ Ð°Ð½Ð°Ð»Ð¸Ð· Ð¸ Ð°Ð½Ð°Ð»Ð¸Ð· ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ ÑÐ½Ð´Ð¾Ð³ÐµÐ½Ð½ÑÑ ÑÐµÑÑÐ¾Ð²Ð¸ÑÑÑÐ¾Ð² ÑÐµÐ¼ÐµÐ¹ÑÑÐ²Ð° HERV-K HML-10 Ð² Ð¶Ð¸ÑÐ¾Ð²Ð¾Ð¹ ÑÐºÐ°Ð½Ð¸ Ñ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ñ Ð¾Ð¶Ð¸ÑÐµÐ½Ð¸ÐµÐ¼ (ÐÐÐ10 Ð66)
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Phylogenetic analysis and analysis of the expression of endogenous retroviruses of the HERV-K HML-10 family in adipose tissue in obese patients (ICD10 E66)
Creators: name: ÐÐ¸Ð½Ð¸ÑÐµÐ½ÐºÐ¾, ÐÐµÑÐ¾Ð½Ð¸ÐºÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: ÑÐ¸Ð»Ð¾Ð³ÐµÐ½ÐµÑÐ¸ÑÐµÑÐºÐ¸Ð¹ Ð°Ð½Ð°Ð»Ð¸Ð·
ÑÐµÑÑÐ¾Ð²Ð¸ÑÑÑ
Ð¿ÑÐ¾Ð²Ð¸ÑÑÑ
ÑÐ½Ð´Ð¾Ð³ÐµÐ½Ð½ÑÐµ ÑÐµÑÑÐ¾Ð²Ð¸ÑÑÑÑ ÑÐµÐ»Ð¾Ð²ÐµÐºÐ°
Ð³ÐµÐ½Ð¾Ð¼
Ð¾Ð±ÑÐ°ÑÐ½Ð°Ñ ÑÑÐ°Ð½ÑÐºÑÐ¸Ð¿ÑÐ¸Ñ
Ð¸Ð½ÑÐµÐ³ÑÐ°ÑÐ¸Ñ Ð² Ð³ÐµÐ½Ð¾Ð¼
Ð±ÐµÐ»ÐºÐ¸ Ð¾Ð±Ð¾Ð»Ð¾ÑÐºÐ¸
Ð¿Ð°ÑÐ¾Ð³ÐµÐ½Ð½ÑÐµ ÑÐ²Ð¾Ð¹ÑÑÐ²Ð°
Ð³ÐµÐ½Ð½Ð°Ñ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ
ÑÐ²Ð¾Ð»ÑÑÐ¸Ñ
ÑÐ²Ð¾Ð»ÑÑÐ¸Ð¾Ð½Ð½ÑÐµ Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ñ
Ð³ÐµÐ½Ð¾Ð¼Ð½ÑÐµ Ð¿Ð¾ÑÐ»ÐµÐ´Ð¾Ð²Ð°ÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸
ÑÐµÑÑÐ¾Ð²Ð¸ÑÑÑÐ½ÑÐµ Ð³ÐµÐ½Ñ
Ð¾Ð¶Ð¸ÑÐµÐ½Ð¸Ðµ
ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ñ
phylogenetic analysis
retrovirus
provirus
endogenous human retroviruses
genome
reverse transcription
integration into the genome
environment proteins
pathogenic properties
gene act internity
evolution
evolutionary relationships
genomic sequences
retroviral genes
obesity
expression

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð°Ð½Ð°Ð»Ð¸Ð·Ñ ÑÐµÑÑÐ¾Ð²Ð¸ÑÑÑÐ¾Ð² ÑÐµÐ¼ÐµÐ¹ÑÑÐ²Ð° HERV-K HML10. Ð ÐµÑÑÐ¾Ð²Ð¸ÑÑÑÑ Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÑÑÑ Ð¾ÑÐ¾Ð±ÑÐ¹ Ð¸Ð½ÑÐµÑÐµÑ Ð´Ð»Ñ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ, Ð¿Ð¾ÑÐºÐ¾Ð»ÑÐºÑ Ð¾Ð½Ð¸ Ð¾ÐºÐ°Ð·ÑÐ²Ð°ÑÑ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Ð½Ð° ÑÑÑÑÐºÑÑÑÑ Ð³ÐµÐ½Ð¾Ð¼Ð° Ð½Ðµ ÑÐ¾Ð»ÑÐºÐ¾ ÑÐµÐ»Ð¾Ð²ÐµÐºÐ°, Ð½Ð¾ Ð¸ Ð´ÑÑÐ³Ð¸Ñ Ð¼Ð»ÐµÐºÐ¾Ð¿Ð¸ÑÐ°ÑÑÐ¸Ñ. Ð Ð°Ð±Ð¾ÑÐ° Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð° Ð½Ð° Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð´ÐµÑÑÐ°Ð±Ð¸Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð³ÐµÐ½Ð¾Ð¼Ð°, ÑÑÐ¾ ÑÐ²Ð»ÑÐµÑÑÑ ÐºÐ»ÑÑÐµÐ²ÑÐ¼ ÑÐ°ÐºÑÐ¾ÑÐ¾Ð¼ Ð² Ð²Ð¾Ð·Ð½Ð¸ÐºÐ½Ð¾Ð²ÐµÐ½Ð¸Ð¸ ÑÑÐ´Ð° Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ð¹, Ð²ÐºÐ»ÑÑÐ°Ñ Ð¾Ð¶Ð¸ÑÐµÐ½Ð¸Ðµ. ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¾ Ð½Ð° Ð°Ð½Ð°Ð»Ð¸Ð· ÑÐ²Ð¾Ð»ÑÑÐ¸Ð¾Ð½Ð½ÑÑ Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ð¹ ÑÐµÑÑÐ¾Ð²Ð¸ÑÑÑÐ¾Ð² Ð³ÑÑÐ¿Ð¿Ñ HERV-K HML10 Ð² Ð³ÐµÐ½Ð¾Ð¼Ðµ ÑÐµÐ»Ð¾Ð²ÐµÐºÐ° Ð¸ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ñ Ð¸Ñ ÑÑÐ¾Ð²Ð½Ñ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð² Ð¶Ð¸ÑÐ¾Ð²Ð¾Ð¹ ÑÐºÐ°Ð½Ð¸ Ñ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ñ Ð¾Ð¶Ð¸ÑÐµÐ½Ð¸ÐµÐ¼ Ð¸ Ð±ÐµÐ·. ÐÑÐ»Ð¾ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¾ Ð´Ð²Ð° Ð¼ÐµÑÐ¾Ð´Ð°: ÑÐ¸Ð»Ð¾Ð³ÐµÐ½ÐµÑÐ¸ÑÐµÑÐºÐ¸Ð¹ Ð°Ð½Ð°Ð»Ð¸Ð·, ÐºÐ¾ÑÐ¾ÑÑÐ¹ Ð¿Ð¾Ð·Ð²Ð¾Ð»ÑÐµÑ Ð¾ÑÐµÐ½Ð¸ÑÑ Ð¸ Ð¿ÑÐ¾Ð¸Ð»Ð»ÑÑÑÑÐ¸ÑÐ¾Ð²Ð°ÑÑ ÑÐ²ÑÐ·Ð¸ Ð¼ÐµÐ¶Ð´Ñ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÐ¼Ð¸ Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ð¼Ð¸ Ð¾Ð±ÑÐµÐºÑÐ°Ð¼Ð¸, Ð¸ Ð°Ð½Ð°Ð»Ð¸Ð· ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð³ÐµÐ½Ð¾Ð² Ð´Ð»Ñ Ð¸Ð·Ð¼ÐµÑÐµÐ½Ð¸Ñ Ð¿ÑÐ¾Ð»Ð¸ÑÐ¸ÑÐ°ÑÐ¸Ð¸ ÑÑÐ°Ð½ÑÐºÑÐ¸Ð¿ÑÐ¾Ð¼Ð° Ð¶Ð¸ÑÐ¾Ð²Ð¾Ð¹ ÑÐºÐ°Ð½Ð¸ ÑÐµÐ»Ð¾Ð²ÐµÐºÐ°. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ Ð´Ð°Ð½Ð½ÑÐµ Ð°ÐºÑÑÐ°Ð»ÑÐ½Ñ Ð´Ð»Ñ Ð¿Ð¾Ð½Ð¸Ð¼Ð°Ð½Ð¸Ñ ÑÐ²Ð¾Ð»ÑÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ Ð¸ ÑÑÐ½ÐºÑÐ¸Ð¾Ð½Ð°Ð»ÑÐ½Ð¾Ð¹ ÑÐ¾Ð»Ð¸ ÑÐµÑÑÐ¾Ð²Ð¸ÑÑÑÐ¾Ð² Ð² Ð³ÐµÐ½Ð¾Ð¼Ðµ ÑÐµÐ»Ð¾Ð²ÐµÐºÐ° Ð¸ Ð´ÑÑÐ³Ð¸Ñ Ð¼Ð»ÐµÐºÐ¾Ð¿Ð¸ÑÐ°ÑÑÐ¸Ñ. ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¾Ð±Ð»Ð°Ð´Ð°ÐµÑ Ð½Ð°ÑÑÐ½Ð¾Ð¹ Ð½Ð¾Ð²Ð¸Ð·Ð½Ð¾Ð¹, Ð¿Ð¾ÑÐºÐ¾Ð»ÑÐºÑ Ð´Ð¾ ÑÐ¸Ñ Ð¿Ð¾Ñ Ð½Ðµ Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸Ð»Ð¾ÑÑ Ð½Ð¸ÐºÐ°ÐºÐ¸Ñ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¹ Ð¿Ð¾ Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ ÑÑÐ¾Ð²Ð½Ñ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ ÑÐ½Ð´Ð¾Ð³ÐµÐ½Ð½ÑÑ ÑÐµÑÑÐ¾Ð²Ð¸ÑÑÑÐ¾Ð² Ð¿ÑÐ¸ Ð¾Ð¶Ð¸ÑÐµÐ½Ð¸Ð¸.
description: The given work is devoted to the analysis of retroviruses of the HERV-K HML10 family. Retroviruses are of particular interest for research because they influence the structure of the genome not only of humans, but also of other mammals. The work is aimed at studying genome destabilization, which is a key factor in the occurrence of a number of diseases, including obesity. The study is aimed at analyzing the evolutionary relationships of retroviruses of the HERV-K HML10 group in the human genome and determining their expression level in adipose tissue in obese and non-obese patients. Two methods were used: phylogenetic analysis, which allows us to evaluate and illustrate the relationships between different biological entities, and gene expression analysis to measure the proliferation of the human adipose tissue transcriptome. The data obtained are relevant for understanding the evolutionary and functional role of retroviruses in the genome of humans and other mammals. This work has scientific novelty, since so far no studies have been conducted to study the level of expression of endogenous retroviruses in obesity.