cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Supporting Computational Biologists at EMBL through open-source tools and four pillars: Training, community, infrastructure and information
Creators: name: Lisanna Paladin
name: Alves, Renato
Publisher: name: F1000 Research Limited
Year: 2023

description: Especially in the interdisciplinary field of computational biology, collaboration is crucial. The Bio-IT project at the European Molecular Biology Laboratory (EMBL) established a community of bioinformaticians through training, community building, infrastructure, and information support. The project is managed by staff, providing a model for how institutional support can empower community-driven initiatives in science.
 Training is an essential component of the Bio-IT project. Researchers learn from their peers through open-source materials and practical workshops, run in a hybrid format to allow participation across all six EMBL sites in Europe. But training alone doesn’t change the culture.It is coupled by community building initiatives such as meetups, coding clubs, an internal Mattermost chat, and a "grassroots table" of internal experts. Infrastructure support includes coding tools and a GitLab server. The project provides newcomers guides, intranet links and a blog to ensure access to comprehensive information.
 The Bio-IT project provides a model for research institutes looking to develop similar programs to support internal field-specific communities. We will highlight the benefits and challenges of implementing this model, and we hope to spark a little revolution in the way scientists approach community and in the way institutions recognise the value of professionals contributing to it.
The Neural Cell Adhesion Molecule L1 Potentiates Integrin-Dependent Cell Migration to Extracellular Matrix Proteins
Creators: name: Midkiff, Bentley R.
name: Panicker, Anitha K.
name: Maness, Patricia F.
name: Thelen, Karsten
name: Schmid, Ralf Steffen
name: Kedar, Vishram
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: The L1 adhesion molecule regulates axon growth and is mutated in the X-linked mental retardation syndrome CRASH (acronym for corpus callosum agenesis, retardation, aphasia, spastic paraplegia, hydrocephalus). A novel role for L1 as a potentiator of neuronal cell migration to extracellular matrix proteins through beta1 integrins and intracellular signaling to mitogen-activated protein (MAP) kinase was identified. L1 potentiated haptotactic migration of B35 neuroblastoma cells toward fibronectin, vitronectin, and laminin through the signaling intermediates c-Src, phosphatidylinositol-3 kinase, and MAP kinase. L1 potentiated migration toward fibronectin through alpha5beta1 integrin in human embryonic kidney 293 cells and depended on determinants of L1 endocytosis: dynamin I, c-Src, and the AP2/clathrin binding site (Arg-Ser-Leu-Glu) in the neuronal splice form of L1. L1 clustering on the cell surface enhanced the internalization of activated beta1 integrins and L1 into distinct endocytic vesicles. L1-potentiated migration, enhancement of beta1 integrin endocytosis, and activation of MAP kinase were coordinately inhibited by mutation of an RGD sequence in the sixth immunoglobulin-like domain of L1. Moreover, three CRASH mutations in the L1 cytoplasmic domain (1194L, S1224L, Y1229H), two of which interfere with ankyrin association, inhibited L1-potentiated migration and MAP kinase activation. Function-blocking antibodies to L1 and beta1 integrin retarded the migration of 5-bromo-2'-deoxyuridine-labeled mouse cerebellar granule cells in slice cultures, underscoring the potential physiological relevance of these findings. These studies suggest that L1 functionally interacts with beta1 integrins to potentiate neuronal migration toward extracellular matrix proteins through endocytosis and MAP kinase signaling, and that impairment of this function by L1 cytoplasmic domain mutations may contribute to neurological deficits in CRASH.
(1333) Agnes [Mayall]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A Specific Inhibitory Pathway between Substantia Gelatinosa Neurons Receiving Direct C-Fiber Input
Creators: name: Lu, Yan
name: Perl, Edward R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: The spinal substantia gelatinosa (SG) is a major termination region for unmyelinated (C) primary afferent fibers; however, how the input it receives from these sensory fibers is processed by SG neurons remains primarily a matter of conjecture. To gain insight on connections and functional interactions between intrinsic SG neurons, simultaneous tight-seal, whole-cell recordings were made from pairs of neurons in rat spinal cord slices to examine whether impulses in one cell generated synaptic activity in the other. Most SG neuron pairs sampled lacked synaptic interaction. Those showing a linkage included a recurring pattern consisting of a monosynaptic, bicuculline-sensitive inhibitory connection from an islet cell to a transient central neuron, each of which received direct excitatory input from different afferent C-fibers. This newly defined inhibitory circuit is postulated to represent a SG neural module by which a nociceptive C-fiber input to transient central cells is modified by other C-fiber messages.
A rotating hairy AdS3 black hole with the metric having only one Killing vector field
Creators: name: Iizuka, Norihiro
name: Ishibashi, Akihiro
name: Maeda, Kengo
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We perturbatively construct a three-dimensional rotating AdS black hole with a real scalar hair. We choose the mass of a scalar field slightly above the Breitenlohner-Freedman bound and impose a more general boundary condition for the bulk scalar field at AdS infinity. We first show that rotating BTZ black holes are unstable against superradiant modes under our more general boundary condition. Next we construct a rotating hairy black hole perturbatively with respect to a small amplitude $ε$ of the scalar field, up to $O(ε^4)$. The lumps of non-linearly perturbed geometry admit only one Killing vector field and co-rotate with the black hole, and it shows no dissipation. We numerically show that the entropy of our hairy black hole is larger than that of the BTZ black hole with the same energy and the angular momentum. This indicates, at least in the perturbative level, that our rotating hairy black hole in lumpy geometry can be the endpoint of the superradiant instability.
description: 6 pages, 2 figures. v2: minor improvements, references and appendix A added
(1334) John Mayhall
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Superconducting gap evolution in overdoped BaFe$_{2}$(As$_{1-x}$P$_x$)$_2$ single crystals through nanocalorimetry
Creators: name: Campanini, D.
name: Diao, Z.
name: Fang, L.
name: Kwok, W-K.
name: Welp, U.
name: Rydh, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We report on specific heat measurements on clean overdoped $\mathrm{BaFe_{2}(As_{1-x}P_x)_2}$ single crystals performed with a high resolution membrane-based nanocalorimeter. A nonzero residual electronic specific heat coefficient at zero temperature $γ_\mathrm{r}={C/T}|_{T \to 0}$ is seen for all doping compositions, indicating a considerable fraction of the Fermi surface ungapped or having very deep minima. The remaining superconducting electronic specific heat is analyzed through a two-band s-wave $α$ model in order to investigate the gap structure. Close to optimal doping we detect a single zero-temperature gap of $Δ_0 \sim 5.3\,\mathrm{meV}$, corresponding to $Δ_0 / k_\mathrm{B} T_\mathrm{c} \sim 2.2$. Increasing the phosphorus concentration $x$, the main gap reduces till a value of $Δ_0 \sim 1.9\,\mathrm{meV}$ for $x = 0.55$ and a second weaker gap becomes evident. From the magnetic field effect on $γ_\mathrm{r}$, all samples however show similar behavior [$γ_\mathrm{r}(H) - γ_\mathrm{r}(H=0) \propto H^n$, with $n$ between 0.6 and 0.7]. This indicates that, despite a considerable redistribution of the gap weights, the total degree of gap anisotropy does not change drastically with doping.
description: 5 pages, 3 figures
(1332) Maria [Clark]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Basolateral Amygdala Neurons Encode Cocaine Self-Administration and Cocaine-Associated Cues
Creators: name: Williams, Jefferson G.
name: Hollander, Jonathan A.
name: Carelli, Regina M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Electrophysiological recording procedures were used to examine basolateral amygdala (BLA) cell firing during cocaine self-administration and relative to response-independent presentations of cocaine-associated stimuli. Of 72 neurons (
Percolation in real interdependent networks
Creators: name: Radicchi, Filippo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: The function of a real network depends not only on the reliability of its own components, but is affected also by the simultaneous operation of other real networks coupled with it. Robustness of systems composed of interdependent network layers has been extensively studied in recent years. However, the theoretical frameworks developed so far apply only to special models in the limit of infinite sizes. These methods are therefore of little help in practical contexts, given that real interconnected networks have finite size and their structures are generally not compatible with those of graph toy models. Here, we introduce a theoretical method that takes as inputs the adjacency matrices of the layers to draw the entire phase diagram for the interconnected network, without the need of actually simulating any percolation process. We demonstrate that percolation transitions in arbitrary interdependent networks can be understood by decomposing these system into uncoupled graphs: the intersection among the layers, and the remainders of the layers. When the intersection dominates the remainders, an interconnected network undergoes a continuous percolation transition. Conversely, if the intersection is dominated by the contribution of the remainders, the transition becomes abrupt even in systems of finite size. We provide examples of real systems that have developed interdependent networks sharing a core of "high quality" edges to prevent catastrophic failures.
description: 7 pages, 4 figures
Aufgaben und Tools für den digitalen FDM-Assistenten "Jarves" – Joint Assistant for Research in Versatile Engineering Services
Creators: name: Robrecht, Michèle
Publisher: name: Zenodo
Year: 2023
Subjects: Forschungsdatenmanagement
FDM
Jarves
TA Frank
FDM-Assistent
FDM-Tools

description: Jarves (Joint Assistant for Research in Versatile Engineering Sciences) soll Forschende durch das gesamte Forschungsdatenmanagement im Rahmen eines Projekts führen [1]. Die folgenden Folien enthalten die Aufgaben, die Jarves abbilden sollte, sowie Tools und Hilfestellungen, die für eine Nachnutzung in diesem FDM-Assistenten in Frage kommen. The authors would like to thank the Federal Government and the Heads of Government of the Länder, as well as the Joint Science Conference (GWK), for their funding and support within the framework of the NFDI4Ing consortium. Funded by the German Research Foundation (DFG) - project number 442146713. Sofern für einzelne Inhalte nicht anders angegeben, steht dieses Werk unter einer Creative Commons Attribution 4.0 International License.
description: {"references": ["Hammann, T. (2023): Jarves: The digital RDM assistant. Joint Assistant for Research in Versatile Engineering Sciences. https://doi.org/10.5281/zenodo.7715684"]}
FAIRsharing – A curated resource on data and metadata standards, with a spotlight on Africa
Creators: name: Lister, Allyson
Publisher: name: Zenodo
Year: 2023

description: FAIRsharing is a curated, informative, and educational resource on data and metadata standards, interrelated to databases and data policies, across all disciplines. This presentation is about the documentation FAIRsharing holds and the services it provides for African research standards, databases, and more.
Learn more about FAIRsharing at https://fairsharing.org. 
Allyson Lister is the FAIRsharing Content & Community Lead at the University of Oxford. With a background in data standardisation, ontologies, semantic data and integration, she is responsible for FAIRsharing content, as well as for collaborations with users and outreach across all research domains. Allyson is also an EOSC Future / RDA Domain Ambassador (for standards, databases and policies), and is a co-chair of two RDA working groups.
Watch the recording of this presentation at https://africarxiv.pubpub.org/pub/rnyoeatk/ 
This webinar session is part of the AfricArXiv Open Science Webinar Series on the Discoverability of African Research, co-organized by UbuntuNet Alliance: https://ubuntunet.net/ and Access 2 Perspectives: https://access2perspectives.org/ as part of the ORCID Global Participation Fund: https://info.orcid.org/global-participation-program/.View all sessions of this webinar series at https://africarxiv.pubpub.org/webinars 
Learn more about ORCID: https://orcid.org/
A critical discourse analysis of a Queensland Coronial Investigation Report
Creators: name: Serginson, Samantha Jane
Publisher: name: University of Southern Queensland
Year: 2021
Subjects: Critical Discourse Analysis, Patient Safety, Coronial investigation, Coroners court, Health care, critical incident, human factors, harm in health care

description: Patient safety is an important issue for hospitals. However, despite efforts to reduce patient harm, adverse events continue to occur. Sudden or unexplained death, the most serious outcome of patient harm, requires mandatory reporting to the coroner. This study set out to examine the language used in coronial investigation reports, as a way of exploring a new perspective of patient safety. Using critical discourse analysis, the study has examined a coronial investigation report published in May 2020 and relating to a March 2018 death in a health care facility. Using Fairclough's (1989) model and method of critical discourse analysis (CDA), the thesis examined the ways in which language is used in the coronial investigation report that frames patient safety. The analysis of the language indicated three discourses: legal, medical, and patient safety/harm. It identified the de-personalised nature of the interactional context of the report and the narrow focus that excluded many aspects of the broader sociocultural context. The findings suggest that hospitals should use proactive strategies with reactive investigations and that is important to think about a wider range of perspectives than those presented in the coronial investigation report.
Supplemental methods and results from Reciprocal abundance shifts of the intertidal sea stars, Evasterias troschelii and Pisaster ochraceus, following sea star wasting disease.
Creators: name: Kay, Sharon W. C.
name: Alyssa-Lois M. Gehman
name: Harley, Christopher D. G.
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: Supplemental methods and results.
Interactive Scalar Quantization for Distributed Resource Allocation
Creators: name: Boyle, Bradford D.
name: Ren, Jie
name: Walsh, John MacLaren
name: Weber, Steven
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: In many resource allocation problems, a centralized controller needs to award some resource to a user selected from a collection of distributed users with the goal of maximizing the utility the user would receive from the resource. This can be modeled as the controller computing an extremum of the distributed users' utilities. The overhead rate necessary to enable the controller to reproduce the users' local state can be prohibitively high. An approach to reduce this overhead is interactive communication wherein rate savings are achieved by tolerating an increase in delay. In this paper, we consider the design of a simple achievable scheme based on successive refinements of scalar quantization at each user. The optimal quantization policy is computed via a dynamic program and we demonstrate that tolerating a small increase in delay can yield significant rate savings. We then consider two simpler quantization policies to investigate the scaling properties of the rate-delay trade-offs. Using a combination of these simpler policies, the performance of the optimal policy can be closely approximated with lower computational costs.
description: 31 pages, 9 figures. Submitted on 2015-05-15 to IEEE Transactions on Signal Processing. Revised 2015-09-06
First measurements of the flux integral with the NIST-4 watt balance
Creators: name: Haddad, D.
name: Seifert, F.
name: Chao, L. S.
name: Cao, A.
name: Sineriz, G.
name: Pratt, J. R.
name: Newell, D. B.
name: Schlamminger, S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: In early 2014, construction of a new watt balance, named NIST-4, has started at the National Institute of Standards and Technology (NIST). In a watt balance, the gravitational force of an unknown mass is compensated by an electromagnetic force produced by a coil in a magnet system. The electromagnetic force depends on the current in the coil and the magnetic flux integral. Most watt balances feature an additional calibration mode, referred to as velocity mode, which allows one to measure the magnetic flux integral to high precision. In this article we describe first measurements of the flux integral in the new watt balance. We introduce measurement and data analysis techniques to assess the quality of the measurements and the adverse effects of vibrations on the instrument.
description: 7 pages, 8 figures, accepted for publication in IEEE Trans. Instrum. Meas. This Journal can be found online at http://ieeexplore.ieee.org/xpl/RecentIssue.jsp?punumber=19
(1330) Jenny Eliza Clark
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Compressed Nonnegative Matrix Factorization is Fast and Accurate
Creators: name: Tepper, Mariano
name: Sapiro, Guillermo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: Nonnegative matrix factorization (NMF) has an established reputation as a useful data analysis technique in numerous applications. However, its usage in practical situations is undergoing challenges in recent years. The fundamental factor to this is the increasingly growing size of the datasets available and needed in the information sciences. To address this, in this work we propose to use structured random compression, that is, random projections that exploit the data structure, for two NMF variants: classical and separable. In separable NMF (SNMF) the left factors are a subset of the columns of the input matrix. We present suitable formulations for each problem, dealing with different representative algorithms within each one. We show that the resulting compressed techniques are faster than their uncompressed variants, vastly reduce memory demands, and do not encompass any significant deterioration in performance. The proposed structured random projections for SNMF allow to deal with arbitrarily shaped large matrices, beyond the standard limit of tall-and-skinny matrices, granting access to very efficient computations in this general setting. We accompany the algorithmic presentation with theoretical foundations and numerous and diverse examples, showing the suitability of the proposed approaches.
A new method for computing the quark-gluon vertex
Creators: name: Aguilar, A. C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this talk we present a new method for determining the nonperturbative quark-gluon vertex, which constitutes a crucial ingredient for a variety of theoretical and phenomenological studies. This new method relies heavily on the exact all-order relation connecting the conventional quark-gluon vertex with the corresponding vertex of the background field method, which is Abelian-like. The longitudinal part of this latter quantity is fixed using the standard gauge technique, whereas the transverse is estimated with the help of the so-called transverse Ward identities. This method allows the approximate determination of the nonperturbative behavior of all twelve form factors comprising the quark-gluon vertex, for arbitrary values of the momenta. Numerical results are presented for the form factors in three special kinematical configurations (soft gluon and quark symmetric limit, zero quark momentum), and compared with the corresponding lattice data.
description: 14 pages, 14 figures. Talk presented at Discrete 2014: Fourth Symposium on Prospects in the Physics of Discrete Symmetries, December 2-6 2014, King's College, London, England
(1331) Matthew Clark
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Brain Activity Evoked by the Perception of Human Walking: Controlling for Meaningful Coherent Motion
Creators: name: Allison, Truett
name: McCarthy, Gregory
name: McKeown, Martin J.
name: Goldstein, Jeremy
name: Pelphrey, Kevin A.
name: Mitchell, Teresa V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Many functional neuroimaging studies of biological motion have used as stimuli point-light displays of walking figures and compared the resulting activations with those evoked by the same display elements moving in a random or noncoherent manner. Although these studies have established that biological motion activates the superior temporal sulcus (STS), the use of random motion controls has left open the possibility that coordinated and meaningful nonbiological motion might activate these same brain regions and thus call into question their specificity for processing biological motion. Here we used functional magnetic resonance imaging and an anatomical region-of-interest approach to test a hierarchy of three questions regarding activity within the STS. First, by comparing responses in the STS with animations of human and robot walking figures, we determined (1) that the STS is sensitive to biological motion itself, not merely to the superficial characteristics of the stimulus. Then we determined that the STS responds more strongly to biological motion (as conveyed by the walking robot) than to (2) a nonmeaningful but complex nonbiological motion (a disjointed mechanical figure) and (3) a complex and meaningful nonbiological motion (the movements of a grandfather clock). In subsequent whole-brain voxel-based analyses, we confirmed robust STS activity that was strongly right lateralized. In addition, we observed significant deactivations in the STS that differentiated biological and nonbiological motion. These voxel-based analyses also revealed regions of motion-related positive activity in other brain regions, including MT or V5, fusiform gyri, right premotor cortex, and the intraparietal sulci.
Supplemental methods and results from Reciprocal abundance shifts of the intertidal sea stars, Evasterias troschelii and Pisaster ochraceus, following sea star wasting disease
Creators: name: Kay, Sharon W. C.
name: Alyssa-Lois M. Gehman
name: Harley, Christopher D. G.
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: Supplemental methods and results.
The Yoneda isomorphism commutes with homology
Creators: name: Peschke, George
name: Van der Linden, Tim
Publisher: name: arXiv
Year: 2015
Subjects: subject: K-Theory and Homology (math.KT)
subject: FOS: Mathematics
subject: Primary: 18E99, 18G50, Secondary: 18E25, 18E40

description: We show that, for a right exact functor from an abelian category to abelian groups, Yoneda's isomorphism commutes with homology and, hence, with functor derivation. Then we extend this result to semiabelian domains. An interpretation in terms of satellites and higher central extensions follows. As an application, we develop semiabelian (higher) torsion theories and the associated theory of (higher) universal (central) extensions.
description: Fixed an inaccuracy in (3.6)
Appendix B: Epidemiological Modelling Tool from Forecasting and control of emerging infectious forest disease through participatory modelling.
Creators: name: Gaydos, Devon A.
name: Petrasova, Anna
name: Cobb, Richard C.
name: Meentemeyer, Ross K.
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: Epidemiological models are powerful tools for evaluating scenarios and visualizing patterns of disease spread, especially when comparing intervention strategies. However, the technical skill required to synthesize and operate computational models frequently renders them beyond the command of the stakeholders who are most impacted by the results. Participatory modelling (PM) strives to restructure the power relationship between modellers and the stakeholders who rely on model insights by involving these stakeholders directly in model development and application; yet, a systematic literature review indicates little adoption of these techniques in epidemiology, especially plant epidemiology. We investigate the potential for PM to integrate stakeholder and researcher knowledge, using Phytophthora ramorum and the resulting sudden oak death disease as a case study. Recent introduction of a novel strain (European 1 or EU1) in southwestern Oregon has prompted significant concern and presents an opportunity for coordinated management to minimize regional pathogen impacts. Using a PM framework, we worked with local stakeholders to develop an interactive forecasting tool for evaluating landscape-scale control strategies. We find that model co-development has great potential to empower stakeholders in the design, development and application of epidemiological models for disease control.This article is part of the theme issue ‘Detection, forecasting and control of infectious disease epidemics: modelling outbreaks in humans, animals and plants Part 2’.
Enhanced Rewarding Properties of Morphine, but not Cocaine, in βarrestin-2 Knock-Out Mice
Creators: name: Bohn, Laura M.
name: Lefkowitz, Robert J.
name: Dykstra, Linda A.
name: Caron, Marc G.
name: Gainetdinov, Raul R.
name: Sotnikova, Tatyana D.
name: Medvedev, Ivan O.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: The reinforcing and psychomotor effects of morphine involve opiate stimulation of the dopaminergic system via activation of mu-opioid receptors (muOR). Both mu-opioid and dopamine receptors are members of the G-protein-coupled receptor (GPCR) family of proteins. GPCRs are known to undergo desensitization involving phosphorylation of the receptor and the subsequent binding of beta(arrestins), which prevents further receptor-G-protein coupling. Mice lacking beta(arrestin)-2 (beta(arr2)) display enhanced sensitivity to morphine in tests of pain perception attributable to impaired desensitization of muOR. However, whether abrogating muOR desensitization affects the reinforcing and psychomotor properties of morphine has remained unexplored. In the present study, we examined this question by assessing the effects of morphine and cocaine on locomotor activity, behavioral sensitization, conditioned place preference, and striatal dopamine release in beta(arr2) knock-out (beta(arr2)-KO) mice and their wild-type (WT) controls. Cocaine treatment resulted in very similar neurochemical and behavioral responses between the genotypes. However, in the beta(arr2)-KO mice, morphine induced more pronounced increases in striatal extracellular dopamine than in WT mice. Moreover, the rewarding properties of morphine in the conditioned place preference test were greater in the beta(arr2)-KO mice when compared with the WT mice. Thus, beta(arr2) appears to play a more important role in the dopaminergic effects mediated by morphine than those induced by cocaine.
(1328) Richard Care
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Circumnuclear Media of Quiescent Supermassive Black Holes
Creators: name: Generozov, Aleksey
name: Stone, Nicholas C.
name: Metzger, Brian D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We calculate steady-state, one-dimensional hydrodynamic profiles of hot gas in slowly accreting ("quiescent") galactic nuclei for a range of central black hole masses $M_{\bullet}$, parametrized gas heating rates, and observationally-motivated stellar density profiles. Mass is supplied to the circumnuclear medium by stellar winds, while energy is injected primarily by stellar winds, supernovae, and black hole feedback. Analytic estimates are derived for the stagnation radius (where the radial velocity of the gas passes through zero) and the large scale gas inflow rate, $\dot{M}$, as a function of $M_{\bullet}$ and the gas heating efficiency, the latter being related to the star-formation history. We assess the conditions under which radiative instabilities develop in the hydrostatic region near the stagnation radius, both in the case of a single burst of star formation and for the average star formation history predicted by cosmological simulations. By combining a sample of measured nuclear X-ray luminosities, $L_x$, of nearby quiescent galactic nuclei with our results for $\dot{M}(M_{\bullet})$ we address whether the nuclei are consistent with accreting in a steady-state, thermally-stable manner for radiative efficiencies predicted for radiatively inefficiency accretion flows. We find thermally-stable accretion cannot explain the short average growth times of low mass black holes in the local Universe, which must instead result from gas being fed in from large radii, due either to gas inflows or thermal instabilities acting on larger, galactic scales. Our results have implications for attempts to constrain the occupation fraction of SMBHs in low mass galaxies using the mean $L_x-M_{\bullet}$ correlation, as well as the predicted diversity of the circumnuclear densities encountered by relativistic outflows from tidal disruption events.
description: 24 pages, 11 figures, 2 tables. Published in MNRAS
Infrastructure Policy Trends: The Digital Divide and the Lack of Broadband Access During COVID-19
Creators: name: Koch, Katharina
Publisher: name: The School of Public Policy Publications
Year: 2020

description: Across Canada, the large number of people working and studying from home require reliable and fast internet access. The COVID-19 pandemic demonstrates the urgency of diminishing the ‘digital divide’ in Canada.
description: The School of Public Policy Publications, Vol. 13 (2020)
Angular Momentum Role in the Hypercritical Accretion of Binary-Driven Hypernovae
Creators: name: Becerra, L.
name: Cipolletta, F.
name: Fryer, C. L.
name: Rueda, Jorge A.
name: Ruffini, R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The induced gravitational collapse (IGC) paradigm explains a class of energetic, $E_{\rm iso}\gtrsim 10^{52}$~erg, long-duration gamma-ray bursts (GRBs) associated with Ic supernovae, recently named binary-driven hypernovae (BdHNe). The progenitor is a tight binary system formed of a carbon-oxygen (CO) core and a neutron star companion. The supernova ejecta of the exploding CO core triggers a hypercritical accretion process onto the neutron star, which reaches in a few seconds the critical mass, and gravitationally collapses to a black hole emitting a GRB. In our previous simulations of this process we adopted a spherically symmetric approximation to compute the features of the hypercritical accretion process. We here present the first estimates of the angular momentum transported by the supernova ejecta, $L_{\rm acc}$, and perform numerical simulations of the angular momentum transfer to the neutron star during the hyperaccretion process in full general relativity. We show that the neutron star: i) reaches in a few seconds either mass-shedding limit or the secular axisymmetric instability depending on its initial mass; ii) reaches a maximum dimensionless angular momentum value, $[c J/(G M^2)]_{\rm max}\approx 0.7$; iii) can support less angular momentum than the one transported by supernova ejecta, $L_{\rm acc} > J_{\rm NS,max}$, hence there is an angular momentum excess which necessarily leads to jetted emission.
description: Accepted for publication in Astrophysical Journal
(1329) William Charles Burras
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Transformando a Sala de Aula: A Eficácia do Aprendizado Híbrido Baseado em Equipe e da Gamificação
Creators: name: Pereira Moreira, Franciely
name: Araújo Lima, Danielli
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 390201
subject: Education policy

description: Este estudo investigou a eficácia do Aprendizado Híbrido Baseado em Equipe em aulas de Ensino Religioso para alunos do 8º e 9º anos do ensino fundamental. A pesquisa, fundamentada em uma revisão sistemática da literatura sobre diferentes abordagens híbridas, adotou o modelo Aprendizado Híbrido Baseado em Equipe em um projeto pedagógico de quatro semanas. Os resultados indicaram que o Aprendizado Híbrido Baseado em Equipe promoveu um alto nível de engajamento dos alunos, contribuindo para o desenvolvimento de habilidades como colaboração, criatividade e pensamento crítico. A análise das autoavaliações revelou a satisfação dos estudantes com a metodologia, destacando a importância da flexibilidade e da personalização do ensino.
Appendix C: Participatory Modelling Workshop from Forecasting and control of emerging infectious forest disease through participatory modelling.
Creators: name: Gaydos, Devon A.
name: Petrasova, Anna
name: Cobb, Richard C.
name: Meentemeyer, Ross K.
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: Epidemiological models are powerful tools for evaluating scenarios and visualizing patterns of disease spread, especially when comparing intervention strategies. However, the technical skill required to synthesize and operate computational models frequently renders them beyond the command of the stakeholders who are most impacted by the results. Participatory modelling (PM) strives to restructure the power relationship between modellers and the stakeholders who rely on model insights by involving these stakeholders directly in model development and application; yet, a systematic literature review indicates little adoption of these techniques in epidemiology, especially plant epidemiology. We investigate the potential for PM to integrate stakeholder and researcher knowledge, using Phytophthora ramorum and the resulting sudden oak death disease as a case study. Recent introduction of a novel strain (European 1 or EU1) in southwestern Oregon has prompted significant concern and presents an opportunity for coordinated management to minimize regional pathogen impacts. Using a PM framework, we worked with local stakeholders to develop an interactive forecasting tool for evaluating landscape-scale control strategies. We find that model co-development has great potential to empower stakeholders in the design, development and application of epidemiological models for disease control.This article is part of the theme issue ‘Detection, forecasting and control of infectious disease epidemics: modelling outbreaks in humans, animals and plants Part 2’.
Uncovering the Structure of Psychopathology Symptoms in Pregnancy and Postpartum
Creators: name: Elysia Davis
name: Demers, Catherine
name: Brandes, Cassandra M
name: Clark, Hannah
name: Hankin, Benjamin
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Clinical Psychology
subject: Developmental Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: In the present study, we aim to examine the measurement of psychopathology in the perinatal to postpartum period vis-à-vis a dimensional and hierarchical structural model. We plan to examine this structure exploratorily, or from the “bottom up” using factor analyses of symptoms ranging from depression to substance use and personality pathology. We will also test the degree to which this structure is similar (i.e., invariant) for distressed and non-distressed individuals and between the prenatal and postpartum periods.
The Evolution of Critical Theory: An Analysis of Dialogue in Pedagogy of the Oppressed
Creators: Priscilla Luu
Publisher: name: University of Alberta Library
Year: 2022

Many theorists disagree on the correct interpretation of Marxism and Critical theory as it has evolved and developed throughout the progression of history. Some claim that Critical theory lacks incorporating diverse perspectives and individual agency while others claim that this is not the original intention of the Scholar. Although the changes seem miniscule, they have grave implications on whether Critical theory is appropriate to how a community can mobilize against Social Justice issues. Is it possible for individuals to unite despite the perpetual differences in ontologies and epistemologies? This research paper uses Sandoval’s Methodology of the Oppressed to compare with Paulo Freire’s Pedagogy of the Oppressed to understand how communities can potentially navigate around individual conceptual differences and generate an ethical commitment for change appropriate to their context.
Noise Based Detection and Segmentation of Nebulous Objects
Creators: name: Akhlaghi, Mohammad
name: Ichikawa, Takashi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: A noise-based non-parametric technique for detecting nebulous objects, for example, irregular or clumpy galaxies, and their structure in noise is introduced. "Noise-based" and "non-parametric" imply that this technique imposes negligible constraints on the properties of the targets and that it employs no regression analysis or fittings. The sub-sky detection threshold is defined and initial detections are found, independently of the sky value. False detections are then estimated and removed using the ambient noise as a reference. This results in a purity level of 0.89 for the final detections as compared to 0.29 for SExtractor when a completeness of 1 is desired for a sample of extremely faint and diffuse mock galaxy profiles. The difference in the mean of the undetected pixels with the known background of mock images is decreased by 4.6 times depending on the diffuseness of the test profiles, quantifying the success in their detection. A non-parametric approach to defining substructure over a detected region is also introduced. NoiseChisel is our software implementation of this new technique. Contrary to the existing signal-based approach to detection, in its various implementations, signal-related parameters such as the image point spread function or known object shapes and models are irrelevant here. Such features make this technique very useful in astrophysical applications such as detection, photometry, or morphological analysis of nebulous objects buried in noise, for example, galaxies that do not generically have a known shape when imaged.
description: NoiseChisel is part of GNU Astronomy Utilities (see https://www.gnu.org/software/gnuastro/ ). All the data-generated numbers and figures in this paper are now exactly reproducible with a `make' command. See `reproduce/README' in the arXiv source files for details and http://astr.tohoku.ac.jp/~akhlaghi/reproduce/1505.01664/ for up-to-date information. All results generated by free software
Functional Genomic Analysis of Remyelination Reveals Importance of Inflammation in Oligodendrocyte Regeneration
Creators: name: Suzuki, Kinuko
name: Ting, Jenny P.Y.
name: Arnett, Heather A.
name: Matsushima, Glenn K.
name: Wang, Ying
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Tumor necrosis factor alpha (TNFalpha), a proinflammatory cytokine, was shown previously to promote remyelination and oligodendrocyte precursor proliferation in a murine model for demyelination and remyelination. We used Affymetrix microarrays in this study to identify (1) changes in gene expression that accompany demyelination versus remyelination and (2) changes in gene expression during the successful remyelination of wild-type mice versus the unsuccessful attempts in mice lacking TNFalpha. Alterations in inflammatory genes represented the most prominent changes, with major histocompatibility complex (MHC) genes dramatically enhanced in microglia and astrocytes during demyelination, remyelination, and as a consequence of TNFalpha stimulation. Studies to examine the roles of these genes in remyelination were then performed using mice lacking specific genes identified by the microarray. Analysis of MHC-II-null mice showed delayed remyelination and regeneration of oligodendrocytes, whereas removal of MHC-I had little effect. These data point to the induction of MHC-II by TNFalpha as an important regulatory event in remyelination and emphasize the active inflammatory response in regeneration after pathology in the brain.