cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Aetiology and Potential Animal Exposure in Central Nervous System Infections in Vietnam.
Creators: name: Brindle, Hannah E
name: Nadjm, Behzad
name: Choisy, Marc
name: Christley, Rob
name: Griffiths, Michael
name: Baker, Stephen
name: Bryant, Juliet E
name: Campbell, James I
name: Nguyen, Van Vinh Chau
name: Nguyen, Thi Ngoc Diep
name: Vu, Ty Thi Hang
name: Nguyen, Van Hung
name: Hoang, Bao Long
name: Le, Xuan Luat
name: Pham, Ha My
name: Ta, Thi Dieu Ngan
name: Ho, Dang Trung Nghia
name: Tran, Thua Nguyen
name: Nguyen, Thi Han Ny
name: Tran, My Phuc
name: Pham, Thi Hong Phuong
name: Le, Van Tan
name: Nguyen, Dac Thuan
name: Hau, Thi Thu Trang
name: Nguyen, Ngoc Vinh
name: Wertheim, Heiman FL
name: Thwaites, Guy E
name: Van Doorn, H Rogier
name: VIZIONS Consortium
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Vietnam
Zoonosis
Central Nervous System Infections
Emerging Infections
Disease Of Unknown Aetiology

description: An estimated 73% of emerging infections are zoonotic in origin, with animal contact and encroachment on their habitats increasing the risk of spill-over events. In Vietnam, close exposure to a wide range of animals and animal products can lead to acquisition of zoonotic pathogens, a number of which cause central nervous system (CNS) infections. However, studies show the aetiology of CNS infections remains unknown in around half of cases. We used samples and data from hospitalised patients with CNS infections, enrolled into the Vietnam Initiative on Zoonotic Infections multicentre study, to determine the association between aetiology and animal contact including those in whom the cause was unknown. Among 933 patients, a pathogen or an antibody response to it was identified in 291 (31.2%, 95% CI 28.3-34.3%). The most common pathogens were Streptococcus suis (n = 91 (9.8%, 8.0-11.9%)) and Japanese encephalitis virus (JEV) (n = 72 (7.7%, 6.1-9.7%)). Commonly reported animal contact included keeping, raising or handling (n = 364 (39.0%, 35.9-42.2%)) and handling, cooking or consuming raw meat, blood or viscera in the 2 weeks prior to symptom onset (n = 371 (39.8%, 36.6-43.0%)), with the latter most commonly from pigs (n = 343 (36.9%, 33.8-40.1%). There was no association between an unknown aetiology and exposure to animals in a multivariate logistic regression. Further testing for unknown or undetected pathogens may increase diagnostic yield, however, given the high proportion of zoonotic pathogens and the presence of risk factors, increasing public awareness about zoonoses and preventive measures can be considered.
Molecular organization of autonomic, respiratory, and spinally-projecting neurons in the mouse ventrolateral medulla
Creators: name: Schwalbe, Dana
Publisher: name: Zenodo
Year: 2023

description: The ventrolateral medulla (VLM) is a crucial region in the brain for visceral and somatic control. It also serves as a significant source of synaptic input to the spinal cord. Experimental studies have shown that gene expression in individual VLM neurons is predictive of their function. However, the organizing principles of the VLM have remained uncertain. This study aimed to create a comprehensive dataset of VLM cells using single-cell RNA sequencing. The dataset was enriched with targeted sequencing of spinally-projecting and adrenergic/noradrenergic VLM neurons. Based on differentially expressed genes, the resulting dataset of 114,805 VLM cells identifies 23 subtypes of neurons, excluding those in the inferior olive, and 5 subtypes of astrocytes. Spinally-projecting neurons were found to be abundant in 7 subtypes of neurons, which were validated through in-situ hybridization. These subtypes included adrenergic/noradrenergic neurons, serotonergic neurons, and neurons expressing gene markers associated with pre-motor neurons in the ventromedial medulla. Further analysis of adrenergic/noradrenergic neurons and serotonergic neurons identified 9 and 6 subtypes, respectively, within each class of monoaminergic neurons. Marker genes that identify the neural network responsible for breathing were concentrated in 2 subtypes of neurons, delineated from each other by markers for excitatory and inhibitory neurons.  These datasets are available for public download and for analysis with a user-friendly interface. Collectively, this study provides a fine-scale molecular identification of cells in the VLM, forming the foundation for a better understanding of the VLM's role in vital functions and motor control.
The deposited file contains the R code used to process, cluster, and visualize the clustered data with Seurat software package for R.
Non-cancellation of electroweak logarithms in high-energy scattering
Creators: name: Manohar, Aneesh V.
name: Shotwell, Brian
name: Bauer, Christian W.
name: Turczyk, Sascha
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study electroweak Sudakov corrections in high energy scattering, and the cancellation between real and virtual Sudakov corrections. Numerical results are given for the case of heavy quark production by gluon collisions involving the rates $gg \to t \bar t, b \bar b, t \bar b W, t \bar t Z, b \bar b Z, t \bar t H, b \bar b H$. Gauge boson virtual corrections are related to real transverse gauge boson emission, and Higgs virtual corrections to Higgs and longitudinal gauge boson emission. At the LHC, electroweak corrections become important in the TeV regime. At the proposed 100 TeV collider, electroweak interactions enter a new regime, where the corrections are very large and need to be resummed.
description: 11 pages, 12 figures, 1 table. v2: Journal version
First Principles Prediction of the Landau Parameter for Fermi Liquids near the Unitarity Limit
Creators: name: Pavaskar, Shashin
name: Rothstein, Ira Z.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: This paper explores the behavior of systems of cold fermions as they approach unitarity above the critical temperature. As we move away from unitarity, by decreasing the scattering length, the dilaton, the Goldstone boson resulting from the spontaneous breaking of Schrodinger symmetry by the Fermi sea, becomes gapped. At energies below this gap, the interaction between quasi-particles will be dominated by local interactions generated by off-shell dilaton exchange. The dilaton mass can, in turn, be related via anomaly matching, to the scattering length and contact parameter within the confines of a systematic expansion. We use this relation to predict the s-wave Landau parameter to be $f=\frac{4πa (2ε(p_F)-p_F^2/m_\star)^2 m}{3p_F^4 \tilde{C}(a)}$ where $a$ is the scattering length, $m$ the atomic mass, $m_\star$, the effective mass which can be extracted from heat capacity, and $\tilde {C}(a)$ is the dimensionless contact parameter. The range of validity of this prediction (given in eq.(21)) is determined by the value of contact parameter and Fermi velocity, which depend upon the scattering length. It is expected to be valid in a range above $k_F a \sim 1$, but the actual window will depend upon the values of aforementioned parameters. Given this result for $f$, we predict the compressibility, spin susceptibility and the quasi-particle life-time.
description: This replacement contains an improved discussion of the range of validity of the EFT and includes a prediction for the spin susceptibility of the Fermi gas. It also fixes an error in the prediction for the Landau parameter and the compressibility in the earlier version
Generalized Location-Scale Mixtures of Elliptical Distributions: Definitions and Stochastic Comparisons
Creators: name: Pu, Tong
name: Zhang, Yiying
name: Yin, Chuancun
Publisher: name: arXiv
Year: 2021
Subjects: subject: Statistics Theory (math.ST)
subject: Probability (math.PR)
subject: FOS: Mathematics

description: This paper proposes a unified class of generalized location-scale mixture of multivariate elliptical distributions and studies integral stochastic orderings of random vectors following such distributions. Given a random vector $\boldsymbol{Z}$, independent of $\boldsymbol{X}$ and $\boldsymbol{Y}$, the scale parameter of this class of distributions is mixed with a function $α(\boldsymbol{Z})$ and its skew parameter is mixed with another function $β(\boldsymbol{Z})$. Sufficient (and necessary) conditions are established for stochastically comparing different random vectors stemming from this class of distributions by means of several stochastic orders including the usual stochastic order, convex order, increasing convex order, supermodular order, and some related linear orders. Two insightful assumptions for the density generators of elliptical distributions, aiming to control the generators' tail, are provided to make stochastic comparisons among mixed-elliptical vectors. Some applications in applied probability and actuarial science are also provided as illustrations on the main findings.
Recopilación Iniciativa Popular de Normas (Chile) - Migración
Creators: name: Esnouf, Sophie
name: Cabieses, Báltica
Publisher: name: figshare
Year: 2022
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Data extracted from the Iniciativa Popular de Normas platform.
Accurate Born-Oppenheimer potentials for excited $Σ^{+}$ states of the hydrogen molecule
Creators: name: Siłkowski, Michał
name: Zientkiewicz, Magdalena
name: Pachucki, Krzysztof
Publisher: name: arXiv
Year: 2021
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We report on highly accurate calculations of Born-Oppenheimer potentials for excited $n\,Σ^{+}$ states of the hydrogen molecule for all possible combinations of singlet/triplet and gerade/ungerade symmetries up to $n=7$. A relative accuracy of $10^{-10}$ (0.00002 cm$^{-1}$) or better is achieved for all the internuclear distances and all the excited states under consideration -- an improvement with respect to the best results available in the literature by at least 6 orders of magnitude. Presented variational calculations rely on efficient evaluation of molecular integrals with the explicitly correlated exponential basis in arbitrary precision arithmetics.
Towards Crowd-aware Indoor Path Planning (Extended Version)
Creators: name: Liu, Tiantian
name: Li, Huan
name: Lu, Hua
name: Cheema, Muhammad Aamir
name: Shou, Lidan
Publisher: name: arXiv
Year: 2021
Subjects: subject: Databases (cs.DB)
subject: Data Structures and Algorithms (cs.DS)
subject: FOS: Computer and information sciences

description: Indoor venues accommodate many people who collectively form crowds. Such crowds in turn influence people's routing choices, e.g., people may prefer to avoid crowded rooms when walking from A to B. This paper studies two types of crowd-aware indoor path planning queries. The Indoor Crowd-Aware Fastest Path Query (FPQ) finds a path with the shortest travel time in the presence of crowds, whereas the Indoor Least Crowded Path Query (LCPQ) finds a path encountering the least objects en route. To process the queries, we design a unified framework with three major components. First, an indoor crowd model organizes indoor topology and captures object flows between rooms. Second, a time-evolving population estimator derives room populations for a future timestamp to support crowd-aware routing cost computations in query processing. Third, two exact and two approximate query processing algorithms process each type of query. All algorithms are based on graph traversal over the indoor crowd model and use the same search framework with different strategies of updating the populations during the search process. All proposals are evaluated experimentally on synthetic and real data. The experimental results demonstrate the efficiency and scalability of our framework and query processing algorithms.
description: The extension of a VLDB'21 paper "Towards Crowd-aware Indoor Path Planning"
DEVELOPMENT AND VALIDATION OF A REVERSE PHASE HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF CARBIDOPA AND LEVODOPA IN PHARMACEUTICAL DOSAGE FORMS
Creators: name: Kethavath Sujatha*, Dr.Nihar Ranjan Das, Dr.K.Balaji
Publisher: name: Zenodo
Year: 2023

description: A new, simple, Accurate, precise, robust and rugged reverse phase-HPLC method was developed for the simultaneous estimation of the Levodopa and Carbidopa in pure and pharmaceutical dosage forms. Chromatogram was run through Hypersil C18 (250 mm×4.6 mm, 5μm) particle size. Mobile phase containing Potassium dihydrogen phosphate (0.03M) (pH-2.8): Methanol (75:25%) was pumped through column at a flow rate of 1.0ml/min. Temperature was maintained at Ambient. Optimized wavelength selected was 226 nm. Retention time of Levodopa and Carbidopa were found to be 1.693min and 3.235min ± 0.02 respectively. The precision %RSD of the Levodopa and Carbidopa were and found to be 0.435 and 0.039 respectively. %Recovery was obtained as 100.06% and 100.083% for Levodopa and Carbidopa respectively. Regression equation of Levodopa is y = 48138x + 5396.0., and y = 71.91x + 42.07 of Carbidopa. The LOD and LOQ values were found to be for the Levodopa and Carbidopa are 1.27µg/ml, 1.16 µg/ml 3.81µg/ml, 3.48µg/ml and the proposed method was found to be simple, precise, accurate, rapid, economic and reproducible for the estimation of Levodopa and Carbidopa in pure form and pharmaceutical marketed formulation.
Keywords: Levodopa and Carbidopa, HPLC, Method Development, Validation.
Rotation of optically bound particle assembly due to scattering induced spin-orbit coupling of light
Creators: name: Tao, Yukihiro
name: Yokoyama, Tomohiro
name: Ishihara, Hajime
Publisher: name: arXiv
Year: 2021
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The optical binding of many particles has great potential to achieve the wide-area formation of a "crystal" of small materials. Unlike conventional optical binding, where the whole assembly of targeted particles is irradiated with light, if one can indirectly manipulate remote particles using a single trapped particle through optical binding, the degrees of freedom to create ordered structures will be greatly enhanced. In this Letter, we theoretically investigate the dynamics of the assembly of gold nanoparticles that is manipulated using a single particle trapped by a focused laser. As a result, we demonstrate that the spin--orbit coupling and angular momentum generation of light via scattering induce the assembly and rotational motion of particles through indirect optical force. This result opens the possibility of creating ordered structures with a wide area and manipulating them, controlling local properties using scanning laser beams.
description: 12 pages with 9 figures
Intersubband optical absorption in InSb stepped quantum wells. Effect of spin sublevels crossing
Creators: name: Hernandez-Cabrera, A.
name: Aceituno, P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study linear and non-linear coefficients of the intersubband absorption in InSb-based stepped quantum wells subjected to an in-plane magnetic field. We consider also a transverse electric field to achieve near resonance conditions. Taking into account the two deepest conduction levels and their corresponding Zeeman spin splitting sublevels, we calculate dispersion relations by means of an improved version of Kane model. Besides the known anti-crossing between down and up spin split sublevels, we obtain an extra spin level crossing for some determined parameters. This crossing clearly modifies the absorption spectrum for transitions among the four sublevels considered. We study a low electron density case, when only the first deepest sublevel is occupied, and a high density case with only the highest sublevel empty. We find a similar behavior of the absorption spectrum in both cases.
description: 15 pages, 11 figures
Multiple Soft Limits of Cosmological Correlation Functions
Creators: name: Joyce, Austin
name: Khoury, Justin
name: Simonović, Marko
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We derive novel identities satisfied by inflationary correlation functions in the limit where two external momenta are taken to be small. We derive these statements in two ways: using background-wave arguments and as Ward identities following from the fixed-time path integral. Interestingly, these identities allow us to constrain some of the O(q^2) components of the soft limit, in contrast to their single-soft analogues. We provide several nontrivial checks of our identities both in the context of resonant non-Gaussianities and in small sound speed models. Additionally, we extend the relation at lowest order in external momenta to arbitrarily many soft legs, and comment on the many-soft extension at higher orders in the soft momentum. Finally, we consider how higher soft limits lead to identities satisfied by correlation functions in large-scale structure.
description: 39 pages, 2 figures. v2: minor corrections, added references. Version to appear in JCAP
Actions of some pointed Hopf algebras on path algebras of quivers
Creators: name: Kinser, Ryan
name: Walton, Chelsea
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Algebra (math.QA)
subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics
subject: 0520, 16S99, 16T05

description: We classify Hopf actions of Taft algebras T(n) on path algebras of quivers, in the setting where the quiver is loopless, finite, and Schurian. As a corollary, we see that every quiver admitting a faithful Z_n-action (by directed graph automorphisms) also admits inner faithful actions of a Taft algebra. Several examples for actions of the Sweedler algebra T(2) and for actions of T(3) are presented in detail. We then extend the results on Taft algebra actions on path algebras to actions of the Frobenius-Lusztig kernel u_q(sl_2), and to actions of the Drinfeld double of T(n).
description: 29 pages. v3: Title changed, and Section 8 is new
Minimal unitary representations from supersymmetry
Creators: name: Bossard, Guillaume
name: Verschinin, Valentin
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We compute the supersymmetry constraints on the R^4 type corrections in maximal supergravity in dimension 8, 6, 4 and 3, and determine the tensorial differential equations satisfied by the function of the scalar fields multiplying the R^4 term in the corresponding invariants. The second order derivative of this function restricted to the Joseph ideal vanishes in dimension lower than six. These results are extended to the d^4 R^4 and the d^6 R^4 corrections, based on the harmonic superspace construction of these invariants in the linearised approximation. We discuss the solutions of these differential equations and analysis the consequences on the non-perturbative type II low energy string theory effective action.
description: 84 pages, Corrected version for publication in JHEP, additional comment on d^6 R^4 in four dimensions
Estimating Redundancy in Clinical Text
Creators: name: Searle, Thomas
name: Ibrahim, Zina
name: Teo, James
name: Dobson, Richard JB
Publisher: name: arXiv
Year: 2021
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences

description: The current mode of use of Electronic Health Record (EHR) elicits text redundancy. Clinicians often populate new documents by duplicating existing notes, then updating accordingly. Data duplication can lead to a propagation of errors, inconsistencies and misreporting of care. Therefore, quantifying information redundancy can play an essential role in evaluating innovations that operate on clinical narratives. This work is a quantitative examination of information redundancy in EHR notes. We present and evaluate two strategies to measure redundancy: an information-theoretic approach and a lexicosyntactic and semantic model. We evaluate the measures by training large Transformer-based language models using clinical text from a large openly available US-based ICU dataset and a large multi-site UK based Trust. By comparing the information-theoretic content of the trained models with open-domain language models, the language models trained using clinical text have shown ~1.5x to ~3x less efficient than open-domain corpora. Manual evaluation shows a high correlation with lexicosyntactic and semantic redundancy, with averages ~43 to ~65%.
Power spectrum tomography of dark matter annihilation with local galaxy distribution
Creators: name: Ando, Shin'ichiro
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Cross-correlating the gamma-ray background with local galaxy catalogs potentially gives stringent constraints on dark matter annihilation. We provide updated theoretical estimates of sensitivities to the annihilation cross section from gamma-ray data with Fermi telescope and 2MASS galaxy catalogs, by elaborating the galaxy power spectrum and astrophysical backgrounds, and adopting the Markov-Chain Monte Carlo simulations. In particular, we show that taking tomographic approach by dividing the galaxy catalogs into more than one redshift slice will improve the sensitivity by a factor of a few to several. If dark matter halos contain lots of bright substructures, yielding a large annihilation boost (e.g., a factor of $\sim$100 for galaxy-size halos), then one may be able to probe the canonical annihilation cross section for thermal production mechanism up to masses of $\sim$700 GeV. Even with modest substructure boost (e.g., a factor of $\sim$10 for galaxy-size halos), on the other hand, the sensitivities could still reach a factor of three larger than the canonical cross section for dark matter masses of tens to a few hundreds of GeV.
description: 28 pages, 14 figures. Accepted by JCAP
Stability and Performance Limits of Adaptive Primal-Dual Networks
Creators: name: Towfic, Zaid J.
name: Sayed, Ali H.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optimization and Control (math.OC)
subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: Machine Learning (cs.LG)
subject: Multiagent Systems (cs.MA)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences

description: This work studies distributed primal-dual strategies for adaptation and learning over networks from streaming data. Two first-order methods are considered based on the Arrow-Hurwicz (AH) and augmented Lagrangian (AL) techniques. Several revealing results are discovered in relation to the performance and stability of these strategies when employed over adaptive networks. The conclusions establish that the advantages that these methods have for deterministic optimization problems do not necessarily carry over to stochastic optimization problems. It is found that they have narrower stability ranges and worse steady-state mean-square-error performance than primal methods of the consensus and diffusion type. It is also found that the AH technique can become unstable under a partial observation model, while the other techniques are able to recover the unknown under this scenario. A method to enhance the performance of AL strategies is proposed by tying the selection of the step-size to their regularization parameter. It is shown that this method allows the AL algorithm to approach the performance of consensus and diffusion strategies but that it remains less stable than these other strategies.
description: 16 pages, 9 figures
DNA in the deep : comparative molecular ecology for the conservation of beaked whales
Creators: name: Onoufriou, Aubrie Booth
Publisher: name: The University of St Andrews
Year: 2023
Subjects: subject: Beaked whales
subject: Molecular ecology
subject: Genomics
subject: ddRAD
subject: Mitogenome
subject: Ziphius cavirostris
subject: Mesoplodon densirostris
subject: Mesoplodon bidens
subject: Hyperoodon ampullatus
subject: Population structure
subject: Genetic diversity
subject: Inbreeding
subject: Demographic history
subject: Anthropogenic noise
subject: QL737.C438O6
subject: Beaked whales--Conservation
subject: Molecular ecology
subject: Genomics

description: Beaked whales (Ziphiidae) are an incredibly diverse and elusive family, and behavioural responses linked to certain anthropogenic sounds have resulted in mass stranding events. The substantial knowledge gaps regarding abundance and population structure for most ziphiids highlight that more information is required for their effective management and conservation. To this end, next-generation DNA sequencing was used to investigate beaked whale ecology and evolution, showcasing the utility of reduced representation sequencing in non-model organisms. Single nucleotide polymorphisms (SNPs) were derived using double-digest restriction site associated DNA sequencing (ddRAD) from a newly established international beaked whale tissue and DNA archive. Globally, hierarchical genetic structure and diversity of cosmopolitan Cuvier’s and Blainville’s beaked whales (Ziphius cavirostris and Mesoplodon densirostris, “Cuvier’s” and “Blainville’s”) were investigated. Biogeographic barriers and differing life and evolutionary histories have contributed to the observed patterns, and the findings are evaluated in the context of management units for conservation. Regionally, population structure and demographic history were characterised for four North Atlantic beaked whales: Cuvier’s, Blainville’s, Sowerby’s beaked whales (M. bidens) and northern bottlenose whales (Hyperoodon ampullatus). Fluctuations in effective population size (Ne) were likely responses to climatic change. With these findings, potential responses of beaked whale populations to future climate change are discussed. Locally, genetic Essential Biodiversity Variables (EBVs) were calculated for paired ‘disturbed’ and ‘semi-pristine’ populations of Cuvier’s and Blainville’s in three well studied populations: the Bahamas, Canary Islands and Mediterranean Sea (Cuvier’s only). At least one ‘disturbed’ site was found in each region with reduced genetic variation and at risk of genetic erosion. In summary, genetic population structure has been identified in many ziphiids. These populations have different levels of genetic diversity, different demographic responses to historic climatic change and it is likely that they have different abilities to adapt to future anthropogenic and climate impacts and should be managed on a population level.
DEVELOPMENT OF NEW ANALYTICAL METHOD AND VALIDATION OF ANTI-NEOPLASTIC AGENTS NETUPITANT AND PALONOSETRON IN PURE AND PHARMACEUTICAL FORMULATION BY RP-HPLC
Creators: name: G.Sadhana*, Dr.K.Balaji
Publisher: name: Zenodo
Year: 2023

description: A novel, precise, accurate, rapid and cost effective isocratic reverse phase high performance liquid chromatographic (RP-HPLC) method was developed, optimized and validated for the estimation of Netupitant (NET) and Palonosetron (PAL) in bulk and pharmaceutical dosage forms. The drugs were estimated using Phenomenex Gemini C18 (4.6mm×150mm, 5µm) particle size column. A mobile phase composed of tri ethylamine buffer and methanol in proportion of 32:68 v/v, at a flow rate of 1.0 ml/min was used for the separation. Detection was carried out at 248nm. The linearity range obtained was 30-70µg/ml for Netupitant and 10-50µg/ml for Palonosetron with retention times (Rt) of 3.297min and 5.405min for Netupitant and Palonosetron respectively. The correlation coefficient values were found to be 0.999 & 0.999. Precession studies showed % RSD values less than 2 % for both the drugs in all the selected concentrations. The percentage recoveries of Netupitant (NET) and Palonosetron (PAL) were found to be 100.1873% for Netupitant and 100.748% for Palonosetron respectively. The assay results of Netupitant (NET) and Palonosetron (PAL) were found to be 99.82%. The limit of detection (LOD) and limit of quantification (LOQ) were 2.6µg/ml and 7.8µg/ml for Netupitant and 3.4µg/ml 10.2µg/ml for Palonosetron respectively. The proposed method was validated as per the International Conference on Harmonization (ICH) guidelines. The proposed validated method was successfully used for the quantitative analysis of commercially available dosage form.
Keywords: Netupitant and Palonosetron, RP-HPLC, ICH Guidelines, Validation.
title: Beyond the pale horse : animals, substitution, and the cost of romance in the 'Orlando furioso'
Creators: name: Grogan, Tess
Publisher: name: University of St Andrews
Year: 2018

description: This study responds to Patricia Parker's landmark account of endlessly expansive romance, suggesting that the genre's structural deferrals and excesses come at a steep hidden price. Like other early modern discourses—rhetoric, economics, empiricism—romance produces a fiction of unmitigated progress which assiduously obscures losses sustained along the way. Ludovico Ariosto's ‘Orlando furioso’ is distinct from later romance epics because it refuses to conceal its own logic, instead staging scenes of cost openly and conspicuously. I suggest that the brutal subroutines sustaining romance's narrative profusion are visible in the poem's exceptionally strange and vital animal figures, which deviate sharply from more conventional images deployed by Ariosto's successors. The first chapter considers the figure of the mother predator, whose irate defense of her abducted offspring serves to augment the wrath of the Furioso's male paladins. These indecorous comparisons destabilize the poem's justifications for violence; by contrast, similar figures in Edmund Spenser's ‘The Faerie Queene’ and Torquato Tasso's ‘Gerusalemme liberata’ reinforce normative hierarchies and place romance's violence beyond question. The second chapter addresses Orlando's savage killing of a female packhorse while in the nadir of his madness. With reference to the poem's other scenes of sexualized violence, I respond to readings that situate Ariosto's mare as a symbol of humanist dialectic advancement, suggesting that the mare's adamant suffering instead exposes the costs exacted by that romance of progress, a disclosure which disappears in the later poems. The stakes of this project are urgent: by attending to the ways in which romance linchpins arme and amori are mapped onto women and female animals, it is possible to trace how sexual violence was understood by a poem with a broad and enduring legacy, and to approach its disclosures as a radical act.
Elements of spin Hurwitz theory: closed algebraic formulas, blobbed topological recursion, and a proof of the Giacchetto-Kramer-Lewanski conjecture
Creators: name: Alexandrov, Alexander
name: Shadrin, Sergey
Publisher: name: arXiv
Year: 2021
Subjects: subject: Mathematical Physics (math-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Algebraic Geometry (math.AG)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 37K10, 14N10, 81R10, 33C80

description: In this paper, we discuss the properties of the generating functions of spin Hurwitz numbers. In particular, for spin Hurwitz numbers with arbitrary ramification profiles, we construct the weighed sums which are given by Orlov's hypergeometric solutions of the 2-component BKP hierarchy. We derive the closed algebraic formulas for the correlation functions associated with these tau-functions, and under reasonable analytical assumptions we prove the loop equations (the blobbed topological recursion). Finally, we prove a version of topological recursion for the spin Hurwitz numbers with the spin completed cycles (a generalized version of the Giacchetto--Kramer--Lewański conjecture).
description: 31 pages, minor corrections
Maximally predictive states: from partial observations to long timescales
Creators: name: Costa, Antonio Carlos
name: Ahamed, Tosif
name: Jordan, David
name: Stephens, Greg
Publisher: name: arXiv
Year: 2021
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Quantitative Methods (q-bio.QM)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Isolating slower dynamics from fast fluctuations has proven remarkably powerful, but how do we proceed from partial observations of dynamical systems for which we lack underlying equations? Here, we construct maximally-predictive states by concatenating measurements in time, partitioning the resulting sequences using maximum entropy, and choosing the sequence length to maximize short-time predictive information. Transitions between these states yield a simple approximation of the transfer operator, which we use to reveal timescale separation and long-lived collective modes through the operator spectrum. Applicable to both deterministic and stochastic processes, we illustrate our approach through partial observations of the Lorenz system and the stochastic dynamics of a particle in a double-well potential. We use our transfer operator approach to provide a new estimator of the Kolmogorov-Sinai entropy, which we demonstrate in discrete and continuous-time systems, as well as the movement behavior of the nematode worm $C. elegans$.
description: 22 pages, 14 figures
Gene annotation for the Aldabra giant tortoise genome assembly, AldGig_1.0
Creators: name: Çilingir, F. Gözde
name: A'Bear, Luke
name: Hansen, Dennis
name: Davis, Leyla R.
name: Bunbury, Nancy
name: Ozgul, Arpat
name: Croll, Daniel
name: Grossen, Christine
Publisher: name: Zenodo
Year: 2022
Subjects: Aldabra giant tortoise, Aldabrachelys gigantea, genome assembly, gene annotation

description: We produced a 2.37 Gbp assembly (AldGig_1.0) with a scaffold N50 of 148.6 Mbp and a resolution into 26 chromosomes for Aldabra giant tortoise (Aldabrachelys gigantea). RNAseq-assisted gene model prediction identified 23,953 protein-coding genes and 1.1 Gbp of repetitive sequences.
Deep Neural Network-Based Blind Multiple User Detection for Grant-free Multi-User Shared Access
Creators: name: Sivalingam, Thushan
name: Ali, Samad
name: Mahmood, Nurul Huda
name: Rajatheva, Nandana
name: Latva-Aho, Matti
Publisher: name: arXiv
Year: 2021
Subjects: subject: Information Theory (cs.IT)
subject: Signal Processing (eess.SP)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Multi-user shared access (MUSA) is introduced as advanced code domain non-orthogonal complex spreading sequences to support a massive number of machine-type communications (MTC) devices. In this paper, we propose a novel deep neural network (DNN)-based multiple user detection (MUD) for grant-free MUSA systems. The DNN-based MUD model determines the structure of the sensing matrix, randomly distributed noise, and inter-device interference during the training phase of the model by several hidden nodes, neuron activation units, and a fit loss function. The thoroughly learned DNN model is capable of distinguishing the active devices of the received signal without any a priori knowledge of the device sparsity level and the channel state information. Our numerical evaluation shows that with a higher percentage of active devices, the DNN-MUD achieves a significantly increased probability of detection compared to the conventional approaches.
description: Accepted for 2021 IEEE 32nd Annual International Symposium on Personal, Indoor and Mobile Radio Communications (PIMRC)-Workshop
Chiral Anomaly and Diffusive Magnetotransport in Weyl Metals
Creators: name: Burkov, A. A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We present a microscopic theory of diffusive magnetotransport in Weyl metals and clarify its relation to chiral anomaly. We derive coupled diffusion equations for the total and axial charge densities and show that chiral anomaly manifests as a magnetic-field-induced coupling between them. We demonstrate that a universal experimentally-observable consequence of this coupling in magnetotransport in Weyl metals is a quadratic negative magnetoresistance, which will dominate all other contributions to magnetoresistance under certain conditions.
description: 5 pages, no figures, published version
Measurement of prompt J/psi pair production in pp collisions at sqrt(s) = 7 TeV
Creators: name: CMS Collaboration
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Production of prompt J/psi meson pairs in proton-proton collisions at sqrt(s) = 7 TeV is measured with the CMS experiment at the LHC in a data sample corresponding to an integrated luminosity of about 4.7 inverse femtobarns. The two J/psi mesons are fully reconstructed via their decays into muon pairs. This observation provides for the first time access to the high-transverse-momentum region of J/psi pair production where model predictions are not yet established. The total and differential cross sections are measured in a phase space defined by the individual J/psi transverse momentum pt[J/psi] and rapidity abs(y[J/psi]): abs(y[J/psi]) < 1.2 for pt[J/psi] > 6.5 GeV; 1.2 < abs(y[J/psi]) < 1.43 for a pt threshold that scales linearly with abs(y[J/psi]) from 6.5 to 4.5 GeV; and 1.43 < abs(y[J/psi]) < 2.2 for pt[J/psi] > 4.5 GeV. The total cross section, assuming unpolarized prompt J/psi pair production is 1.49 +/- 0.07 (stat.) +/- 0.13 (syst.) nb. Different assumptions about the J/psi polarization imply modifications to the cross section ranging from -31% to +27%.
description: Replaced with published version. Added journal reference and DOI
Key-Sparse Transformer for Multimodal Speech Emotion Recognition
Creators: name: Chen, Weidong
name: Xing, Xiaofeng
name: Xu, Xiangmin
name: Yang, Jichen
name: Pang, Jianxin
Publisher: name: arXiv
Year: 2021
Subjects: subject: Sound (cs.SD)
subject: Audio and Speech Processing (eess.AS)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Speech emotion recognition is a challenging research topic that plays a critical role in human-computer interaction. Multimodal inputs further improve the performance as more emotional information is used. However, existing studies learn all the information in the sample while only a small portion of it is about emotion. The redundant information will become noises and limit the system performance. In this paper, a key-sparse Transformer is proposed for efficient emotion recognition by focusing more on emotion related information. The proposed method is evaluated on the IEMOCAP and LSSED. Experimental results show that the proposed method achieves better performance than the state-of-the-art approaches.
description: This paper was accepted by ICASSP 2022
Stability of Topological Insulators with Non-Abelian Edge Excitations
Creators: name: Cappelli, Andrea
name: Randellini, Enrico
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Chiral-antichiral pairs of non-Abelian Hall states, like the Pfaffian, Read-Rezayi and NASS states, can be used to model two-dimensional time-reversal invariant topological insulators. Their stability was shown to be associated to the presence of a Z_2 anomaly and characterized by the same Z_2 index introduced for free fermion and Abelian systems. In this work, we continue the stability analysis by providing the form of time-reversal invariant interactions that gap the non-Abelian edge excitations. Our approach is based on the description of non-Abelian states as projections of corresponding "parent" Abelian states.
description: 33 pages, 1 figure; updated discussion of interactions
Evidence for spin-triplet odd-parity superconductivity close to type-II van Hove singularities
Creators: name: Meng, Zi Yang
name: Yang, Fan
name: Chen, Kuang-Shing
name: Yao, Hong
name: Kee, Hae-Young
Publisher: name: arXiv
Year: 2014
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Searching for unconventional Cooper pairing states has been at the heart of superconductivity research since the discovery of BCS superconductors. In particular, spin-triplet odd-parity pairing states were recently revisited due to the possibility of tuning towards topological superconductors. In this context, it is interesting to note a recent proposal that such a spin-triplet pairing instability occurs when the band filling is near van Hove singularities (vHS) associated with momenta away from time-reversal invariant momenta named type-II vHS. However, this result was obtained within a weak coupling renormalization group with Fermi surface patch approximation. To explore superconducting instabilities beyond this weak coupling Fermi surface patch approximation, we perform systematic study on Hubbard model in a two-dimensional square lattice using three different methods: random phase approximation, large-scale dynamical mean field theory simulations with continuous time quantum Monte Carlo (CTQMC) impurity solver, and large-scale dynamical cluster simulations with CTQMC cluster solver. We find, in a wide doping range centered around the type-II van Hove filling, a two-fold degenerate, spin-triplet, odd-parity $p$-wave pairing state emerges due to repulsive interaction, when the Fermi surface is not sufficiently nested. Possible relevance of our findings to the recently discovered superconductors LaO$_{1-x}$F$_{x}$BiS$_{2}$, Ir$_{1-x}$Pt$_{x}$Te$_{2}$ and proposed doped BC$_{3}$ are also discussed.
description: 9 pages, 9 figures
Nonlocal Gravity: The General Linear Approximation
Creators: name: Mashhoon, B.
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The recent classical nonlocal generalization of Einstein's theory of gravitation is presented within the framework of general relativity via the introduction of a preferred frame field. The nonlocal generalization of Einstein's field equations is derived. The linear approximation of nonlocal gravity (NLG) is thoroughly examined and the solutions of the corresponding field equations are discussed. It is shown that nonlocality, with a characteristic length scale of order 1 kpc, simulates dark matter in the linear regime while preserving causality. Light deflection in linearized nonlocal gravity is studied in connection with gravitational lensing; in particular, the propagation of light in the weak gravitational field of a uniformly moving source is investigated. The astrophysical implications of the results are briefly mentioned.
description: 51 pages; v2: Ref. [23] updated
Maximally twisted eleven-dimensional supergravity
Creators: name: Eager, Richard
name: Hahner, Fabian
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: Algebraic Geometry (math.AG)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We perform the maximal twist of eleven-dimensional supergravity. This twist is partially topological and exists on manifolds of $G_2 \times SU(2)$ holonomy. Our derivation starts with an explicit description of the Batalin-Vilkovisky complex associated to the three-form multiplet in the pure spinor superfield formalism. We then determine the $L_\infty$ module structure of the supersymmetry algebra on the component fields. We twist the theory by modifying the differential of the Batalin-Vilkovisky complex to incorporate the action of a scalar supercharge. We find that the resulting free twisted theory is given by the tensor product of the de Rham and Dolbeault complexes of the respective $G_2$ and $SU(2)$ holonomy manifolds as conjectured by Costello.
description: 40 pages, 10 tables
title: NOAA Science Advisory Board Report on the Review of the Cooperative Institute for the North Atlantic Region (CINAR)
title: NOAA SAB Report on the Review of the Cooperative Institute for the North Atlantic Region (CINAR);External review of the Cooperative Institute for the North Atlantic Region (CINAR)
titleType: AlternativeTitle
Creators: name: NOAA Science Advisory Board
Publisher: name: NOAA Science Advisory Board
Year: 2023
Subjects: Coperative Institute

description: Review of the Cooperative Institute for the North Atlantic Region (CINAR) by the NOAA Science Advisory Board (SAB). CINAR is a consortium of eight academic institutions formed to promote research, training, and outreach through collaborative research aligning with NOAA’s mission. This report was presented to and endorsed by the SAB at its meeting on July 27, 2023
Dispatchable Region for Active Distribution Networks Using Approximate Second-Order Cone Relaxation
Creators: name: Li, Zhigang
name: Huang, Wenjing
name: Zheng, J. H.
name: Wu, Q. H.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Systems and Control (eess.SY)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Uncertainty in distributed renewable generation threatens the security of power distribution systems. The concept of the dispatchable region was developed to assess the ability of power systems to accommodate renewable generation at a given operating point. Although DC and linearized AC power flow equations are typically used to model dispatchable regions for transmission systems, these equations are rarely suitable for distribution networks. To achieve a suitable trade-off between accuracy and efficiency, this paper proposes a dispatchable region formulation for distribution networks using tight convex relaxation. Second-order cone relaxation is adopted to reformulate the AC power flow equations, which are then approximated by a polyhedron to improve tractability. Further, an efficient adaptive constraint generation algorithm is employed to construct the proposed dispatchable region. Case studies on distribution systems of various scales validate the computational efficiency and accuracy of the proposed method.
description: 10 pages, 10 figures
Moderating effect of Social Networks on the relationship between Adverse Childhood Experiences and Suicide Outcomes
Creators: name: Cero, Ian
name: Oumou Toure
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Medicine and Health Sciences
subject: Social and Behavioral Sciences
subject: ACEs
subject: Social Network
subject: Suicide

description: Do basic social network characteristics in adolescence weaken the association between the ACEs experienced in youth and adult suicidal ideation and attempts?