cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Infant Visual Brain Development and Inherited Genetic Liability in Autism
Creators: name: Botteron, K.N
name: Hazlett, H.C
name: Shen, M.D
name: Gerig, G
name: Styner, M
name: Pandey, J
name: Kim, S.H
name: Wolff, J.J
name: Snyder, A.Z
name: Talovic, M
name: Hawks, Z
name: McKinstry, R
name: Davis, S
name: Nishino, T
name: Estes, A.M
name: Schultz, R.T
name: Elison, J.T
name: Forsen, E
name: Piven, J
name: Girault, J.B
name: Pruett, Jr., J.R
name: John, T.S
name: Truong, Y
name: Swanson, M.R
name: Dager, S.R
name: Donovan, K
name: Todorov, A
name: Zwaigenbaum, L.
name: Constantino, J.N
Publisher: name: American Psychiatric Association
Year: 2022

description: Objective: Autism spectrum disorder (ASD) is heritable, and younger siblings of ASD probands are at higher likelihood of developing ASD themselves. Prospective MRI studies of siblings report that atypical brain development precedes ASD diagnosis, although the link between brain maturation and genetic factors is unclear.Given that familial recurrence of ASD is predicted by higher levels of ASD traits in the proband, the authors investigated associations between proband ASD traits and brain development among younger siblings. Methods: In a sample of 384 proband-sibling pairs (89 pairs concordant for ASD), the authors examined associations between proband ASD traits and sibling brain development at 6, 12, and 24 months in key MRI phenotypes: total cerebral volume, cortical surface area, extra-axial cerebrospinal fluid, occipital cortical surface area, and splenium white matter microstructure. Results from primary analyses led the authors to implement a data-driven approach using functional connectivity MRI at 6 months. Results: Greater levels of proband ASD traits were associated with larger total cerebral volume and surface area and larger surfaceareaandreducedwhitematter integrityincomponents ofthevisual systeminsiblingswhodevelopedASD.Thisaligned withweaker functional connectivitybetween several networks and the visual system among all siblings during infancy. Conclusions: The findings provide evidence that specific early brain MRI phenotypes of ASD reflect quantitative variation in familial ASD traits. Multimodal anatomical and functional convergence on cortical regions, fiber pathways, and functional networks involved in visual processing suggest that inherited liability has a role in shaping the prodromal development of visual circuitry in ASD.
Infantile Iron Deficiency Affects Brain Development in Monkeys Even After Treatment of Anemia
Creators: name: Styner, M.A
name: Coe, C.L
name: Kling, P.J
name: Wang, Q
name: Lubach, G.R
name: Vlasova, R.M
name: Rao, R.B
name: Willette, A
name: Georgieff, M.K
Publisher: name: Frontiers Media S.A.
Year: 2021

description: A high percent of oxidative energy metabolism is needed to support brain growth during infancy. Unhealthy diets and limited nutrition, as well as other environmental insults, can compromise these essential developmental processes. In particular, iron deficiency anemia (IDA) has been found to undermine both normal brain growth and neurobehavioral development. Even moderate ID may affect neural maturation because when iron is limited, it is prioritized first to red blood cells over the brain. A primate model was used to investigate the neural effects of a transient ID and if deficits would persist after iron treatment. The large size and postnatal growth of the monkey brain makes the findings relevant to the metabolic and iron needs of human infants, and initiating treatment upon diagnosis of anemia reflects clinical practice. Specifically, this analysis determined whether brain maturation would still be compromised at 1 year of age if an anemic infant was treated promptly once diagnosed. The hematology and iron status of 41 infant rhesus monkeys was screened at 2-month intervals. Fifteen became ID; 12 met clinical criteria for anemia and were administered iron dextran and B vitamins for 1–2 months. MRI scans were acquired at 1 year. The volumetric and diffusion tensor imaging (DTI) measures from the ID infants were compared with monkeys who remained continuously iron sufficient (IS). A prior history of ID was associated with smaller total brain volumes, driven primarily by significantly less total gray matter (GM) and smaller GM volumes in several cortical regions. At the macrostructual level, the effect on white matter volumes (WM) was not as overt. However, DTI analyses of WM microstructure indicated two later-maturating anterior tracts were negatively affected. The findings reaffirm the importance of iron for normal brain development. Given that brain differences were still evident even after iron treatment and following recovery of iron-dependent hematological indices, the results highlight the importance of early detection and preemptive supplementation to limit the neural consequences of ID.
title: Konstruktion und Validierung einer Vorrichtung zur Gasaufbereitung für die sauerstofffreie Produktion
Creators: name: Zimmermann, S.
name: Gustus, R.
name: Maus-Friedrichs, W.
Publisher: name: TU Clausthal
Year: 2025
Subjects: subject: 620

description: Durch die Verwendung des Gasgemisches Argon/Silan innerhalb einer Handschuhbox können sauerstofffreie Atmosphären geschaffen werden. Dies eröffnet der Industrie weitreichende Möglichkeiten, Bauteile mit innovativen Materialeigenschaften herzustellen, indem die Oxidbildung auf Metalloberflächen verhindert wird. Solch eine Atmosphäre kann besonders beim Walzplattieren oder beim Lichtbogenspritzverfahren für eine bessere Anbindung der Metalle sorgen. Es hat sich jedoch gezeigt, dass die Reaktion von Silan mit Wasser kinetisch gehemmt ist und die verbleibende Restfeuchtigkeit in der Atmosphäre zur Oxidbildung führen kann. Zusätzlich kann sich der entstandene SiO2-Staub durch die Reaktion von Silan mit Sauerstoff an den Oberflächen ablagern und somit die Materialeigenschaften negativ beeinflussen. Daher ist eine Vorrichtung zur Gasaufbereitung erforderlich, die sowohl die SiO2-Partikel als auch die verbleibende Restfeuchtigkeit herausfiltert und gleichzeitig die Konzentrationen der Gase Sauerstoff, Wasserstoff und Restwasser überwacht. In diesem Zusammenhang wird die Adsorptionseffizienz des Molekuarsiebs für Wasser untersucht. Zusätzlich werden verschiedene Filterbauelemente verwendet, welche den SiO2-Staub aus der Atmosphäre filtern und die empfindlichen Sensoren schützen. Das Projekt zur sauerstofffreien Produktion wird in einem interdisziplinären Sonderforschungsbereich (SFB) in Kooperation mit der Leibniz Universität Hannover und dem Laser-Zentrum Hannover e.V. durchgeführt.
description: Tagungsband 6. Symposium Materialtechnik: 20. bis 21. Februar 2025
Interaction of in-plane magnetic skyrmions with 90$^\circ$ magnetic domain walls: micromagnetic simulations
Creators: name: Baláž, Pavel
Publisher: name: arXiv
Year: 2022
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: $90^\circ$ pinned magnetic domain walls can be observed in thin magnetic layers attached to a ferroelectric substrate. The main stabilization mechanism of the noncollinear magnetic texture is the strain transfer which is responsible for imprinting of the ferroelectic domains into the uniaxial anisotropy of the ferromagnet. Here, we investigate by means of micromagnetic simulations how the interfacial Dzyaloshinkii-Moriya interaction influences the $90^\circ$ domain wall structure. It is shown that Dzyaloshinskii-Moriya interaction induces a large out-of-plane magnetization component, strongly dependent on the domain wall type. In particular, it is shown that this out-of-plane magnetization component is crucial for the transport of the in-plane magnetic skyrmions, also known as bimerons, through the magnetic domain walls. Based on the results of micromagnetic simulations, a concept of in-plane magnetic skyrmion valve based on two $90^\circ$ pinned magnetic domain walls is introduced.
Infection and inflammation: New perspectives on Alzheimer's disease
Creators: name: Goate A
name: Spudich S.S
name: Sisodia S
name: Stevens B
name: Symposium Planning Committee Members
name: Ting J.P
name: Colton C
name: Heneka M.T
name: Garden G
name: Whitson H.E
name: Kaddurah-Daouk R
name: Tanzi R
name: Shinohara M.L
name: Klein R.S
name: Gate D
name: El Khoury J
Publisher: name: Elsevier Inc.
Year: 2022

description: Neuroinflammation has been recognized as a component of Alzheimer's Disease (AD) pathology since the original descriptions by Alois Alzheimer and a role for infections in AD pathogenesis has long been hypothesized. More recently, this hypothesis has gained strength as human genetics and experimental data suggest key roles for inflammatory cells in AD pathogenesis. To review this topic, Duke/University of North Carolina (Duke/UNC) Alzheimer's Disease Research Center hosted a virtual symposium: “Infection and Inflammation: New Perspectives on Alzheimer's Disease (AD).” Participants considered current evidence for and against the hypothesis that AD could be caused or exacerbated by infection or commensal microbes. Discussion focused on connecting microglial transcriptional states to functional states, mouse models that better mimic human immunity, the potential involvement of inflammasome signaling, metabolic alterations, self-reactive T cells, gut microbes and fungal infections, and lessons learned from Covid-19 patients with neurologic symptoms. The content presented in the symposium, and major topics raised in discussions are reviewed in this summary of the proceedings.
Mitochondrial Isolevuglandins Contribute to Vascular Oxidative Stress and Mitochondria-Targeted Scavenger of Isolevuglandins Reduces Mitochondrial Dysfunction and Hypertension
Creators: name: Dikalov, Sergey
name: Dikalova, Anna
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 310103
subject: Cell metabolism

description: Hypertension remains a major health problem in Western Societies, and blood pressure is poorly controlled in a third of patients despite use of multiple drugs. Mitochondrial dysfunction contributes to hypertension and mitochondria-targeted agents can potentially improve treatment of hypertension. We have proposed that mitochondrial oxidative stress produces reactive dicarbonyl lipid peroxidation products isolevuglandins (isoLGs) and that scavenging of mitochondrial isoLG improves vascular function and reduces hypertension. To test this hypothesis, we have studied the accumulation of mitochondrial isoLGs-protein adducts in patients with essential hypertension and angiotensin II model of hypertension using mass spectrometry and Western blot analysis. The therapeutic potential of targeting mitochondrial isoLG was tested by the novel mitochondria-targeted isoLG scavenger, mito2HOBA. Mitochondrial isoLGs in arterioles from hypertensive patients were 250% greater than in arterioles from normotensive subjects, and ex vivo mito2HOBA treatment of arterioles from hypertensive subjects increased deacetylation of a key mitochondrial antioxidant, superoxide dismutase 2 (SOD2). In human aortic endothelial cells stimulated with angiotensin II plus TNFα, mito2HOBA reduced mitochondrial superoxide and cardiolipin oxidation, a specific marker of mitochondrial oxidative stress. In angiotensin II-infused mice, mito2HOBA diminished mitochondrial isoLGs-protein adducts, raised Sirt3 mitochondrial deacetylase activity, reduced vascular superoxide, increased endothelial nitric oxide, improved endothelium-dependent relaxation, and attenuated hypertension. Mito2HOBA preserved mitochondrial respiration, protected ATP production, and reduced mitochondrial permeability pore opening in angiotensin II-infused mice. These data support the role of mitochondrial isoLGs in endothelial dysfunction and hypertension. We conclude that scavenging of mitochondrial isoLGs may have therapeutic potential in treatment of vascular dysfunction and hypertension.
Influence of gonadal steroids on cortical surface area in infancy
Creators: name: Alex, A.M
name: Wang, L
name: Li, G
name: Xia, K
name: Jha, S.C
name: Girault, J.B
name: Ruvio, T
name: Gilmore, J.H
name: Knickmeyer, R.C
name: Shen, D
name: Cornea, E
name: Styner, M.A
Publisher: name: Oxford University Press
Year: 2022

description: Sex differences in the human brain emerge as early as mid-gestation and have been linked to sex hormones, particularly testosterone. Here, we analyzed the influence of markers of early sex hormone exposure (polygenic risk score (PRS) for testosterone, salivary testosterone, number of CAG repeats, digit ratios, and PRS for estradiol) on the growth pattern of cortical surface area in a longitudinal cohort of 722 infants. We found PRS for testosterone and right-hand digit ratio to be significantly associated with surface area, but only in females. PRS for testosterone at the most stringent P value threshold was positively associated with surface area development over time. Higher right-hand digit ratio, which is indicative of low prenatal testosterone levels, was negatively related to surface area in females. The current work suggests that variation in testosterone levels during both the prenatal and postnatal period may contribute to cortical surface area development in female infants.
Resolving the Multiplicity of Exoplanet Host Stars in Gemini/NIRI Data
Creators: name: Miskovetz, Kim
name: Dupuy, Trent J.
name: Schonhut-Stasik, Jessica
name: Stassun, Keivan G.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The majority of stars have one or more stellar companions. As exoplanets continue to be discovered, it is crucial to examine planetary systems to identify their stellar companions. By observing a change in proper motion, companions can be detected by the acceleration they induce on their host stars. We selected 701 stars from the Hipparcos-Gaia Catalog of Accelerations (HGCA) that have existing adaptive optics imaging data gathered with Gemini/NIRI. Of these, we examined 21 stars known to host planet candidates and reduced their archival NIRI data with Gemini's DRAGONS software. We assessed these systems for companions using the NIRI images as well as Renormalized Unit Weight Error values in Gaia and accelerations in the HGCA. We detected three known visible companions and found two more systems with no visible companions but astrometric measurements indicating likely unresolved companions.
description: 4 pages, 1 table
Influence of voids on the thermal and light stability of perovskite solar cells
Creators: name: Huang J
name: Wang M
name: Fei C
name: Uddin M.A
Publisher: name: American Association for the Advancement of Science
Year: 2022

description: The formation of voids in perovskite films close to the buried interface has been reported during film deposition. These voids are thought to limits the efficiency and stability of perovskite solar cells (PSCs). Here, we studied the voids formed during operation in perovskite films that were optimized during the solution deposition process to avoid voids. New voids formed during operation are found to assemble along grain boundaries at the bottom interface, caused by the loss of residual solvent and conversion of amorphous phase to crystalline phase. Unexpectedly, the formation of these voids did not negatively affect the stability of PSCs. Decreasing the amorphous region in perovskites by thermal annealing decreased the positive iodide interstitial density, and improved the light stability of PSCs. The annealed devices maintained 90% of their initial efficiency and light soaking for 1900 hours at open circuit condition under 1-sun illumination at 50°C.
Inhibiting PI3 kinase-γ in both myeloid and plasma cells remodels the suppressive tumor microenvironment in desmoplastic tumors
Creators: name: Shen, L
name: Huang, L
name: Zhang, X
name: Liu, Q
name: Hou, L
Publisher: name: Elsevier B.V.
Year: 2019

description: Phosphoinositide-3-kinases (PI3Ks) are part of signal transducing enzymes that mediate key cellular functions in cancer and immunity. PI3K-γ is crucial for cellular activation and migration in response to certain chemokines. PI3K-γ is highly expressed in myeloid cells and promotes their migration and the production of inflammatory mediators. We found that PI3K-γ was also highly expressed in tumor-associated B cells. IPI-549, the only PI3K-γ inhibitor in clinical development, offers a unique approach to enhance the anti-tumor immune response. We encapsulated IPI-549 in targeted polymeric nanoparticles (NP) and tested its activity in both murine pancreatic cancer and melanoma models. IPI-549 NP significantly decreased tumor growth and prolonged host survival in both models. Importantly, IPI-549 NP treatment reduced the suppressive tumor microenvironment by decreasing both suppressive myeloid and plasma cells in the tumor. We concluded that IPI-549 NP delivery could be a promising method for treating pancreatic cancer and other immune-suppressive tumors.
Producción científica en Colombia relacionada con ciencia abierta, métricas de nueva generación y métricas responsables en el contexto de Publindex y SCIENTI
Creators: name: Información, conocimiento y sociedad, Grupo de investigación
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 461005
subject: Informetrics
classificationCode: 461007
subject: Open access
classificationCode: 461003
subject: Human information interaction and retrieval
classificationCode: 461002
subject: Human information behaviour

description: Abstract: This article presents a topic review on the publications by Colombian authors in recent years with regard to open science, new-generation metrics (altmetrics), and responsible metrics, in contextual interrelation with the country’s practices for evaluating and measuring scientific journals (Publindex) and research groups and researchers (SCIENTI), considering the changes implied by the recently approved National Open Science Policy. The list of texts, selected via qualitative analysis, is an important input in the discussions and new constructions around said National Policy, in order for the assessment, recognition, and evaluation of activities involving science, technology, and innovation in the country to include responsible metrics and alternative open science indicators aimed at assessing the diversity of the products and processes carried out, as well as the different economic, social, and territorial impacts caused by these practices.

Resumen: Este artículo presenta una revisión del tema sobre la publicación de autores colombianos durante los últimos años (2000-2020) en relación con la ciencia abierta, las métricas de nueva generación (altmetrics) y las métricas responsables, en interrelación contextual con las prácticas de evaluación y medición de revistas científicas (Publindex) y de grupos de investigación e investigadores (SCIENTI) en el país, considerando los cambios que implica la reciente aprobación de la Política Nacional de Ciencia Abierta. El listado de textos, seleccionados mediante un análisis cualitativo, es un insumo importante en las discusiones y nuevas construcciones en torno a dicha Política Nacional, para que la valoración, el reconocimiento y la evaluación de las actividades de ciencia, tecnología e innovación del país incluyan métricas responsables e indicadores alternativos de ciencia abierta centrados en valorar la diversidad de los productos y los procesos adelantados, así como los diferentes impactos económicos, sociales y territoriales generados por estas prácticas.
A Tale of Two Flows: Cooperative Learning of Langevin Flow and Normalizing Flow Toward Energy-Based Model
Creators: name: Xie, Jianwen
name: Zhu, Yaxuan
name: Li, Jun
name: Li, Ping
Publisher: name: arXiv
Year: 2022
Subjects: subject: Machine Learning (stat.ML)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: This paper studies the cooperative learning of two generative flow models, in which the two models are iteratively updated based on the jointly synthesized examples. The first flow model is a normalizing flow that transforms an initial simple density to a target density by applying a sequence of invertible transformations. The second flow model is a Langevin flow that runs finite steps of gradient-based MCMC toward an energy-based model. We start from proposing a generative framework that trains an energy-based model with a normalizing flow as an amortized sampler to initialize the MCMC chains of the energy-based model. In each learning iteration, we generate synthesized examples by using a normalizing flow initialization followed by a short-run Langevin flow revision toward the current energy-based model. Then we treat the synthesized examples as fair samples from the energy-based model and update the model parameters with the maximum likelihood learning gradient, while the normalizing flow directly learns from the synthesized examples by maximizing the tractable likelihood. Under the short-run non-mixing MCMC scenario, the estimation of the energy-based model is shown to follow the perturbation of maximum likelihood, and the short-run Langevin flow and the normalizing flow form a two-flow generator that we call CoopFlow. We provide an understating of the CoopFlow algorithm by information geometry and show that it is a valid generator as it converges to a moment matching estimator. We demonstrate that the trained CoopFlow is capable of synthesizing realistic images, reconstructing images, and interpolating between images.
description: 23 pages
ImageSig: A signature transform for ultra-lightweight image recognition
Creators: name: Ibrahim, Mohamed R.
name: Lyons, Terry
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: This paper introduces a new lightweight method for image recognition. ImageSig is based on computing signatures and does not require a convolutional structure or an attention-based encoder. It is striking to the authors that it achieves: a) an accuracy for 64 X 64 RGB images that exceeds many of the state-of-the-art methods and simultaneously b) requires orders of magnitude less FLOPS, power and memory footprint. The pretrained model can be as small as 44.2 KB in size. ImageSig shows unprecedented performance on hardware such as Raspberry Pi and Jetson-nano. ImageSig treats images as streams with multiple channels. These streams are parameterized by spatial directions. We contribute to the functionality of signature and rough path theory to stream-like data and vision tasks on static images beyond temporal streams. With very few parameters and small size models, the key advantage is that one could have many of these "detectors" assembled on the same chip; moreover, the feature acquisition can be performed once and shared between different models of different tasks - further accelerating the process. This contributes to energy efficiency and the advancements of embedded AI at the edge.
Information leakage resistant quantum dialogue with single photons in both polarization and spatial-mode degrees of freedom
Creators: name: Ye, Tian-Yu
name: Li, Hong-Kun
name: Hu, Jia-Li
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In this paper, a novel quantum dialogue (QD) protocol is proposed based on single photons in both polarization and spatial-mode degrees of freedom. In the proposed QD protocol, the initial states of single photons in both polarization and spatial-mode degrees of freedom used for encoding are privately shared between two communicants through the direct transmissions of their auxiliary counterparts from one communicant to another. As a result, the information leakage problem is avoided. Moreover, the detailed security analysis also shows that the proposed QD protocol can resist Eve's several famous active attacks, such as the Trojan horse attack, the intercept-resend attack, the measure-resend attack and the entangle-measure attack. The proposed QD protocol only needs single photons in both polarization and spatial-mode degrees of freedom as quantum resource and adopts single-photon measurements. As a result, it is feasible in practice as the preparation and the measurement of a single photon in both polarization and spatial-mode degrees of freedom can be accomplished with current experimental techniques.
description: 9 pages, 1 figure, 4 tables
Inhibition of estrogen signaling in myeloid cells increases tumor immunity in melanoma
Creators: name: Chang, C.-Y
name: Mukherjee, D
name: Brueckner, O
name: Lim, F
name: Perou, C.M
name: Bae, Y
name: Artham, S
name: Tavares, K
name: Hanks, B.A
name: Chakraborty, B
name: Wardell, S.E
name: Haines, C.N
name: Gong, W
name: Baldi, R
name: Shepherd, J
name: Liu, W
name: Byemerwa, J
name: McDonnell, D.P
Publisher: name: American Society for Clinical Investigation
Year: 2021

description: Immune checkpoint blockade (ICB) therapies have significantly prolonged patient survival across multiple tumor types, particularly in melanoma. Interestingly, sex-specific differences in response to ICB have been observed, with males receiving a greater benefit from ICB than females, although the mechanism or mechanisms underlying this difference are unknown. Mining published transcriptomic data sets, we determined that the response to ICBs is influenced by the functionality of intratumoral macrophages. This puts into context our observation that estrogens (E2) working through the estrogen receptor α (ERα) stimulated melanoma growth in murine models by skewing macrophage polarization toward an immune-suppressive state that promoted CD8+ T cell dysfunction and exhaustion and ICB resistance. This activity was not evident in mice harboring macrophage-specific depletion of ERα, confirming a direct role for estrogen signaling within myeloid cells in establishing an immunosuppressed state. Inhibition of ERα using fulvestrant, a selective estrogen receptor downregulator (SERD), decreased tumor growth, stimulated adaptive immunity, and increased the antitumor efficacy of ICBs. Further, a gene signature that determines ER activity in macrophages predicted survival in patients with melanoma treated with ICB. These results highlight the importance of E2/ER signaling as a regulator of intratumoral macrophage polarization, an activity that can be therapeutically targeted to reverse immune suppression and increase ICB efficacy.
Supplementary document for Chemical bath synthesis of Ag₂S, CuS, and CdS nanoparticle-polymer nanocomposites: structural, linear, and nonlinear optical characteristics - 5883868.pdf
Creators: name: Fatemi, Ali
name: Rasouli, Milad
name: Ghoranneviss, Mahmood
name: Dorranian, D.
name: Ostrikov, Ken
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized
Nonlinear Optics and Spectroscopy

description: SEM analyses
title: ÐÑÐ½Ð¾ÑÐµÐ½Ð¸Ðµ Ðº ÑÐ¸ÑÑÐ¾Ð²ÑÐ¼ ÑÐ¾ÑÐ¼Ð°ÑÐ°Ð¼ Ð¿ÑÐ¾ÑÐµÑÑÐ¸Ð¾Ð½Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÑÑÐ´ÐµÐ½ÑÐ¾Ð² Ð²ÑÐ·Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Attitudes towards digital formats of professional education of university students
Creators: name: ÐÐ°ÑÐ¸Ð»ÐµÐ½ÐºÐ¾, ÐÐ»ÐµÐºÑÐ°Ð½Ð´ÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: ÑÐ¸ÑÑÐ¾Ð²ÑÐµ ÑÐ¾ÑÐ¼Ð°ÑÑ
ÑÐ¸ÑÑÐ¾Ð²Ð°Ñ Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°ÑÐµÐ»ÑÐ½Ð°Ñ ÑÑÐµÐ´Ð°
ÑÐ¸ÑÑÐ¾Ð²Ð¸Ð·Ð°ÑÐ¸Ñ
Ð¿ÑÐ¾ÑÐµÑÑÐ¸Ð¾Ð½Ð°Ð»ÑÐ½Ð¾Ðµ Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ðµ
digital formats
digital educational environment
digitalization
professional education

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ñ Ðº ÑÐ¸ÑÑÐ¾Ð²ÑÐ¼ ÑÐ¾ÑÐ¼Ð°ÑÐ°Ð¼ Ð¿ÑÐ¾ÑÐµÑÑÐ¸Ð¾Ð½Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÑÑÐ´ÐµÐ½ÑÐ¾Ð² Ð³ÑÐ¼Ð°Ð½Ð¸ÑÐ°ÑÐ½ÑÑ Ð¸ ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ñ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ð¹ Ð¿Ð¾Ð´Ð³Ð¾ÑÐ¾Ð²ÐºÐ¸, Ð¼ÑÐ¶ÑÐ¸Ð½ Ð¸ Ð¶ÐµÐ½ÑÐ¸Ð½. ÐÑÐ» Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½ ÑÐµÐ¾ÑÐµÑÐ¸ÑÐµÑÐºÐ¸Ð¹ Ð°Ð½Ð°Ð»Ð¸Ð· Ð¿ÑÐ¸ÑÐ¾Ð»Ð¾Ð³Ð¾-Ð¿ÐµÐ´Ð°Ð³Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð»Ð¸ÑÐµÑÐ°ÑÑÑÑ Ð¿Ð¾ Ð¿ÑÐ¾Ð±Ð»ÐµÐ¼Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ. ÐÑÑÐ²Ð»ÐµÐ½Ñ Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸ Ð² Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ð¸ Ðº ÑÐ¸ÑÑÐ¾Ð²ÑÐ¼ ÑÐ¾ÑÐ¼Ð°ÑÐ°Ð¼ Ð¸ Ð¸Ñ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð² ÑÑÐµÐ±Ð½Ð¾Ð¹, Ð¿ÑÐ¾ÐµÐºÑÐ½Ð¾Ð¹, Ð½Ð°ÑÑÐ½Ð¾-Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°ÑÐµÐ»ÑÑÐºÐ¾Ð¹ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ Ð¿Ð¾ ÑÐ°ÐºÑÐ¾ÑÑ Ð¿Ð¾Ð»Ð° Ð¸ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ Ð¿Ð¾Ð´Ð³Ð¾ÑÐ¾Ð²ÐºÐ¸. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ Ð´Ð°Ð½Ð½ÑÐµ Ð±ÑÐ»Ð¸ Ð¾Ð±ÑÐ°Ð±Ð¾ÑÐ°Ð½Ñ Ð¼ÐµÑÐ¾Ð´Ð°Ð¼Ð¸ Ð¼Ð°ÑÐµÐ¼Ð°ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÑÐ°ÑÐ¸ÑÑÐ¸ÐºÐ¸.
description: This work is devoted to the study of attitudes to digital formats of professional education of students of humanitarian and technical areas of training, men and women. The theoretical analysis of psychological and pedagogical literature on the research problem was carried out. The peculiarities in the attitude to digital formats and their application in educational, project, research activities by gender and training direction were revealed. The obtained data were processed by methods of mathematical statistics.
Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets
Creators: name: Dukhovlinova E
name: Ahn S
name: Hu Q
name: Wen D
name: Archibong E
name: Gu Z
name: Kang Y
name: Li H
name: Dotti G
name: Ruan H
name: Chen Q
Publisher: name: Nature Research
Year: 2021

description: The immunosuppressive microenvironment of solid tumours reduces the antitumour activity of chimeric antigen receptor T cells (CAR-T cells). Here, we show that the release—through the implantation of a hyaluronic acid hydrogel—of CAR-T cells targeting the human chondroitin sulfate proteoglycan 4, polymer nanoparticles encapsulating the cytokine interleukin-15 and platelets conjugated with the checkpoint inhibitor programmed death-ligand 1 into the tumour cavity of mice with a resected subcutaneous melanoma tumour inhibits the local recurrence of the tumour as well as the growth of distant tumours, through the abscopal effect. The hydrogel, which functions as a reservoir, facilitates the enhanced distribution of the CAR-T cells within the surgical bed, and the inflammatory microenvironment triggers platelet activation and the subsequent release of platelet-derived microparticles. The post-surgery local delivery of combination immunotherapy through a biocompatible hydrogel reservoir could represent a translational route for preventing the recurrence of cancers with resectable tumours.
¿Qué sabemos y qué hemos hecho sobre creatividad en educación superior?
Creators: name: Andrea, Sanchez Vallejo
Publisher: name: Zenodo
Year: 2022
Subjects: creatividad, educación superior, fomento de la creatividad, inhibición de la creatividad, percepciones sobre creatividad.
creativity, higher education, creativity promotion, creativity inhibition, perceptions of creativity.

description: This document presents the result of a systematic retrieval of 86 articles that explore the topic of creativity in higher education. From the selection of the 50 most relevant articles, it is possible to show that it is possible to promote creativity in higher education through different strategies; it is also found that there is an interest in investigating the perceptions of teachers and students about creativity regarding the elements that may inhibit its expression and enhancement. Another group of articles offers some guidelines for its promotion in universities. A following group of articles presents the main conceptualizations of the construct. To conclude, the predominant topic of the reviewed studies is oriented to the development and promotion of creativity.
description: Documento no arbitrado.
Use of sick pens in turkey farming
Creators: name: EURCAW-Poultry-SFA
Publisher: name: Zenodo
Year: 2025
Subjects: subject: Turkeys
subject: Sick pen
subject: Injured animals

description: According to Directive 98/58/EC, sick or injured poultry must receive immediate care, including isolation in suitable accommodation. A sick pen is a designated area for temporarily housing birds requiring special attention, reducing competition, stress, and disease spread while promoting recovery. It must be easily accessible, well-lit, and physically separated from healthy birds. Proper bedding, lower stocking density (≥50% lower than the main group), and access to feed and water are essential. Daily monitoring helps identify birds needing treatment or humane euthanasia (Regulation 1099/2009). Sick pens should be modular for adaptability, particularly during critical periods (e.g., early brooding or pre-slaughter). Effective management, including proper use of hides, minimizes aggression and supports rehabilitation, ensuring compliance with animal welfare regulations.
Injectable Biodegradable Polymeric Complex for Glucose-Responsive Insulin Delivery
Creators: name: Wang Z
name: Wang J
name: Liu X
name: Li H
name: Buse J.B
name: Zhou D
name: Chen G
name: Meng H
name: Kahkoska A.R
name: Wang Y
name: Zhou Z
name: Ci T
name: Gu Z
Publisher: name: American Chemical Society
Year: 2021

description: Insulin therapy is the central component of treatment for type 1 and advanced type 2 diabetes; however, its narrow therapeutic window is associated with a risk of severe hypoglycemia. A glucose-responsive carrier that demonstrates consistent and slow basal insulin release under a normoglycemic condition and accelerated insulin release in response to hyperglycemia in real-time could offer effective blood glucose regulation with reduced risk of hypoglycemia. Here, we describe a poly(l-lysine)-derived biodegradable glucose-responsive cationic polymer for constructing polymer-insulin complexes for glucose-stimulated insulin delivery. The effects of the modification degree of arylboronic acid in the synthesized cationic polymer and polymer-to-insulin ratio on the glucose-dependent equilibrated free insulin level and the associated insulin release kinetics have been studied. In addition, the blood glucose regulation ability of these complexes and the associated glucose challenge-triggered insulin release are evaluated in type 1 diabetic mice.
Integrated DNA and RNA Sequencing Reveals Drivers of Endocrine Resistance in Estrogen Receptor–Positive Breast Cancer
Creators: name: He, X
name: Martinez-Perez, C
name: Dixon, J.M
name: Renshaw, L
name: Xia, Y
name: Kay, C
name: Turnbull, A
name: Parker, J.S
name: Carey, L.A
name: Gray, M
name: Perou, C.M
name: Meehan, J
Publisher: name: American Association for Cancer Research Inc.
Year: 2022

description: Purpose: Endocrine therapy resistance (ETR) remains the greatest challenge in treating patients with hormone receptor–positive breast cancer. We set out to identify molecular mechanisms underlying ETR through in-depth genomic analysis of breast tumors. Experimental Design: We collected pre-treatment and sequential on-treatment tumor samples from 35 patients with estrogen receptor–positive breast cancer treated with neoadjuvant then adjuvant endocrine therapy; 3 had intrinsic resistance, 19 acquired resistance, and 13 remained sensitive. Response was determined by changes in tumor volume neoadjuvantly and by monitoring for adjuvant recurrence. Twelve patients received two or more lines of endocrine therapy, with subsequent treatment lines being initiated at the time of development of resistance to the previous endocrine therapy. DNA whole-exome sequencing and RNA sequencing were performed on all samples, totalling 169 unique specimens. DNA mutations, copy-number alterations, and gene expression data were analyzed through unsupervised and supervised analyses to identify molecular features related to ETR. Results: Mutations enriched in ETR included ESR1 and GATA3. The known ESR1 D538G variant conferring ETR was identified, as was a rarer E380Q variant that confers endocrine hypersensitivity. Resistant tumors which acquired resistance had distinct gene expression profiles compared with paired sensitive tumors, showing elevated pathways including ER, HER2, GATA3, AKT, RAS, and p63 signaling. Integrated analysis in individual patients highlighted the diversity of ETR mechanisms. Conclusions: The mechanisms underlying ETR are multiple and characterized by diverse changes in both somatic genetic and transcriptomic profiles; to overcome resistance will require an individualized approach utilizing genomic and genetic biomarkers and drugs tailored to each patient.
Multi-party quantum private comparison based on entanglement swapping of Bell entangled states within d-level quantum system
Creators: name: Ye, Tian-Yu
name: Hu, Jia-Li
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In this paper, a multi-party quantum private comparison (MQPC) scheme is suggested based on entanglement swapping of Bell entangled states within d-level quantum system, which can accomplish the equality comparison of secret binary sequences from n users via one execution of scheme. Detailed security analysis shows that both the outside attack and the participant attack are ineffective. The suggested scheme needn't establish a private key among n users beforehand through the quantum key distribution (QKD) method to encrypt the secret binary sequences. Compared with previous MQPC scheme based on d-level Cat states and d-level Bell entangled states, the suggested scheme has distinct advantages on quantum resource, quantum measurement of third party (TP) and qubit efficiency.
description: 8 pages, 1 figure, 1 table
Supplementary document for Chemical bath synthesis of Ag₂S, CuS, and CdS nanoparticle-polymer nanocomposites: structural, linear, and nonlinear optical characteristics - 5883868.pdf
Creators: name: Fatemi, Ali
name: Rasouli, Milad
name: Ghoranneviss, Mahmood
name: Dorranian, D.
name: Ostrikov, Ken
Publisher: name: Optica Publishing Group
Year: 2022
Subjects: Uncategorized
Nonlinear Optics and Spectroscopy

description: SEM analyses
Supplementary files for "Metagenomic Data Integration for Microbial Oceanography". Werneck Salazar, Vinícius. Doctoral dissertation, The University of Melbourne, 2025.
Creators: name: Salazar, Vinicius
Publisher: name: The University of Melbourne
Year: 2025
Subjects: classificationCode: 310509
subject: Genomics
classificationCode: 370801
subject: Biological oceanography
classificationCode: 310201
subject: Bioinformatic methods development

description: Supplementary files for "Metagenomic Data Integration for Microbial Oceanography", doctoral dissertation by Vinícius Werneck Salazar, The University of Melbourne, 2025.For enquiries, please email vinicius.salazar [ at ] unimelb.edu.au.Description:UGCMP_Struo2_db_metadata.txt.gz: Metadata for reference sequences in the UGCMP Struo2 database.
title: Culturally responsive self-efficacy and self-perceptions of native English speaker teachers (NEST) and non-native English speaker teachers (NNEST)
Creators: name: Borji Mashhadi, Saeideh
Publisher: name: Memorial University of Newfoundland
publisherIdentifier: https://ror.org/04haebc03
publisherIdentifierScheme: ROR
Year: 2024

description: This study investigates the culturally responsive self-efficacy and self-perceptions of Native English Speaker Teachers (NESTs) and Non-native English Speaker Teachers (NNESTs) in K-12 schools in Newfoundland and Labrador, Canada. The study aims to compare the culturally responsive teaching self-efficacy beliefs and self-perceptions between these two groups of teachers within linguistically and culturally diverse classrooms. A qualitative research design was employed, utilizing semi-structured interviews and non-participant classroom observations to collect data. Eight ESL teachers were interviewed, and two were observed to gain insights into their teaching strategies, interactions with students, and classroom management techniques. The study's thematic analysis reveals that both NESTs and NNESTs demonstrate a commitment to fostering inclusive classrooms. However, they differ in their levels of self-efficacy and self-perception, influenced by their linguistic backgrounds, professional training, and experiences. Key findings reveal variances in self-efficacy and self-perception between NESTs and NNESTs, shaped by linguistic backgrounds, training, and experiences. Interactions with diverse students bolstered self-efficacy, while gaps in training and institutional support hindered the implementation of culturally responsive practices. The study underscores the need for inclusive, fair, and culturally responsive environments in education, emphasizing the importance of training and hiring practices that reflect student diversities. It advocates for an educational setting that mirrors the multicultural and multilingual realities of students, urging stakeholders to recognize the unique challenges and strengths of both NESTs and NNESTs in fostering a globally representative educational landscape.
Insights into distinct signaling profiles of the µOR activated by diverse agonists
Creators: name: Che T
name: Seven A.B
name: Huang W
name: Aydin D
name: Skiniotis G
name: Robertson M.J
name: Inoue A
name: Chakraborty S
name: DiBerto J.F
name: Majumdar S
name: Qu Q
name: Wang H
name: Kobilka B.K
name: Paggi J.M
name: Dror R.O
name: Suomivuori C.-M
name: Roth B.L
Publisher: name: Nature Research
Year: 2023

description: Drugs targeting the μ-opioid receptor (μOR) are the most effective analgesics available but are also associated with fatal respiratory depression through a pathway that remains unclear. Here we investigated the mechanistic basis of action of lofentanil (LFT) and mitragynine pseudoindoxyl (MP), two μOR agonists with different safety profiles. LFT, one of the most lethal opioids, and MP, a kratom plant derivative with reduced respiratory depression in animal studies, exhibited markedly different efficacy profiles for G protein subtype activation and β-arrestin recruitment. Cryo-EM structures of μOR-Gi1 complex with MP (2.5 Å) and LFT (3.2 Å) revealed that the two ligands engage distinct subpockets, and molecular dynamics simulations showed additional differences in the binding site that promote distinct active-state conformations on the intracellular side of the receptor where G proteins and β-arrestins bind. These observations highlight how drugs engaging different parts of the μOR orthosteric pocket can lead to distinct signaling outcomes.
NODES_Inndiana_Z17_Low Concentration of Butyrate Reverts PA-Induced Atrophic Conditon on C2C12 Myotubes
Creators: name: University of Eastern Piedmont Amadeo Avogadro
Publisher: name: Zenodo
Year: 2024
Subjects: Spoke 5 - Industry for Health and Silver Economy
INNDIANA Project
Eco healthcare
ECS00000036

description: ENDO2023 congress, Chicago
Enhanced spectral broadening via self-phase modulation with femtosecond optical pulses in silicon nanowires integrated with 2D graphene oxide films
Creators: name: Zhang, Yuning
name: Wu, Jiayang
name: Yang, Yunyi
name: Qu, Yang
name: Jia, Linnan
name: Jia, Baohua
name: Moss, David J.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We experimentally demonstrate enhanced spectral broadening of femtosecond optical pulses af-ter propagation through silicon-on-insulator (SOI) nanowire waveguides integrated with two-dimensional (2D) graphene oxide (GO) films. Owing to the strong mode overlap between the SOI nanowires and the GO films with a high Kerr nonlinearity, the self-phase modulation (SPM) process in the hybrid waveguides is significantly enhanced, resulting in greatly improved spectral broadening of the femtosecond optical pulses. A solution-based, transfer-free coating method is used to integrate GO films onto the SOI nanowires with precise control of the film thickness. Detailed SPM measurements using femtosecond optical pulses are carried out, achieving a broadening factor of up to ~4.3 for a device with 0.4-mm-long, 2 layers of GO. By fit-ting the experimental results with theory, we obtain an improvement in the waveguide nonlin-ear parameter by a factor of ~3.5 and the effective nonlinear figure of merit (FOM) by a factor of ~3.8, relative to the uncoated waveguide. Finally, we discuss the influence of GO film length on the spectral broadening and compare the nonlinear optical performance of different integrated waveguides coated with GO films. These results confirm the improved nonlinear optical per-formance for silicon devices integrated with 2D GO films.
description: 16 pages, 6 figures, 53 references, 1 table
title: ÐÑÐ½Ð¾ÑÐµÐ½Ð¸Ðµ Ðº ÐºÐ¸Ð±ÐµÑÐ±ÑÐ»Ð»Ð¸Ð½Ð³Ñ Ð¸ Ð¸Ð½Ð´Ð¸Ð²Ð¸Ð´ÑÐ°Ð»ÑÐ½Ð¾-Ð¿ÑÐ¸Ñ Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸ ÑÑÑÐ´ÐµÐ½ÑÐ¾Ð²
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Attitude to cyberbullying and individual psychological characteristics of students
Creators: name: ÐÐ²Ð°Ð½Ð¾Ð²Ð°, ÐÑÐ¸ÑÑÐ¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: ÐºÐ¸Ð±ÐµÑÐ±ÑÐ»Ð»Ð¸Ð½Ð³
ÑÐ¸ÑÑÐ¾Ð²Ð°Ñ ÑÑÐµÐ´Ð°
Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ðµ ÑÑÑÐ´ÐµÐ½ÑÐ¾Ð²
ÑÑÐ°Ð²Ð»Ñ Ð² Ð¸Ð½ÑÐµÑÐ½ÐµÑÐµ
cyberbullying
digital environment
student attitude
internet bullying

description: ÐÐºÑÑÐ°Ð»ÑÐ½Ð¾ÑÑÑ ÑÐ°Ð±Ð¾ÑÑ Ð·Ð°ÐºÐ»ÑÑÐ°ÐµÑÑÑ Ð² ÑÐ¾Ð¼, ÑÑÐ¾ Ð¾Ð½Ð° Ð¿Ð¾Ð·Ð²Ð¾Ð»ÑÐµÑ Ð³Ð»ÑÐ±Ð¶Ðµ Ð¿Ð¾Ð½ÑÑÑ Ð¿ÑÐ¾Ð±Ð»ÐµÐ¼Ñ Ð¸ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ ÐºÐ¸Ð±ÐµÑÐ±ÑÐ»Ð»Ð¸Ð½Ð³Ð° Ð½Ð° ÑÑÑÐ´ÐµÐ½ÑÐ¾Ð². Ð ÑÐ°Ð±Ð¾ÑÐµ Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ñ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ, Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð¼ÐµÑÐ¾Ð´Ð¸Ðº Ð. Ð. ÐÐ¾ÑÐºÐ¸Ð½Ð¾Ð¹ Â«ÐÑÐ»Ð»Ð¸Ð½Ð³âÑÑÑÑÐºÑÑÑÑÂ» Ð¸ Ð. Ð. Ð¡Ð¾Ð»Ð¾Ð¼Ð¸Ð½Ð° Â«Ð¦Ð²ÐµÑÐ¾Ð²ÑÐµ Ð¼ÐµÑÐ°ÑÐ¾ÑÑÂ», Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð° Ð¾Ð¿ÑÑÐ½Ð¾- ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ°, ÑÐ²ÑÐ·Ð°Ð½Ð½Ð°Ñ Ñ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ¾Ð¹ Ð°Ð½ÐºÐµÑÑ Â«ÐÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð»ÑÐ´ÐµÐ¹ Ð² Ð¸Ð½ÑÐµÑÐ½ÐµÑÐµÂ», Ð° ÑÐ°ÐºÐ¶Ðµ ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ñ Ð¾Ð½Ð»Ð°Ð¹Ð½ â ÐºÑÑÑÐ° Ð¿Ð¾ Ð¿ÑÐ¾ÑÐ¸Ð»Ð°ÐºÑÐ¸ÐºÐµ ÑÑÐ°Ð²Ð»Ð¸ Ð² Ð¸Ð½ÑÐµÑÐ½ÐµÑÐµ. ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð° Ð¾Ð¿ÑÑÐ½Ð¾ â ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ°, ÑÐ²ÑÐ·Ð°Ð½Ð½Ð°Ñ Ñ Ð°Ð¿ÑÐ¾Ð±Ð°ÑÐ¸ÐµÐ¹ ÐºÑÑÑÐ° Ð¿Ð¾ Ð¿ÑÐ¾ÑÐ¸Ð»Ð°ÐºÑÐ¸ÐºÐµ ÐºÐ¸Ð±ÐµÑÐ±ÑÐ»Ð»Ð¸Ð½Ð³Ð°. Ð­ÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ñ Ð¸ Ð¾Ð½Ð»Ð°Ð¹Ð½ â ÐºÑÑÑÐ° Ð¿Ð¾Ð´ÑÐ²ÐµÑÐ¶Ð´ÐµÐ½Ð° Ð¿Ð¾Ð»Ð¾Ð¶Ð¸ÑÐµÐ»ÑÐ½ÑÐ¼Ð¸ Ð¾ÑÐ·ÑÐ²Ð°Ð¼Ð¸, Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÐ¼Ð¸ Ð½Ð° Ð²ÑÑÐ¾Ð´Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¸ ÑÐºÑÐ¿ÐµÑÑÐ½Ð¾Ð¹ Ð¾ÑÐµÐ½ÐºÐ¾Ð¹.
description: The relevance of the work lies in the fact that it allows us to better understand the problem and the impact of cyberbullying on students. This work is devoted to the problem of the development of digital competence of teachers of a teacher training college. The paper presents the results of the study, based on the methods of E. G. Norkina âBullying structuresâ and I. L. Solomin âColor metaphorsâ, experimental work was carried out related to the development of the questionnaire âFeatures of interaction of people on the Internetâ, as well as creating an online course on the prevention of bullying on the Internet. Experimental work was carried out related to the testing of a course on the prevention of cyberbullying. The effectiveness of the program and online course is confirmed by positive feedback received from the study and expert assessment.