Gene polymorphism associated with <i>FOXP3</i>, <i>CTLA-4</i> and susceptibility to pre-eclampsia: a meta-analysis and trial sequential analysis
Creators: name: Liu, Jing
name: Song, Guang
name: Zhao, Ge
name: Meng, Tao
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Previous studies have detected the correlation of polymorphisms in regulatory T cells associated genes <i>FOXP3</i> and <i>CTLA-4</i> with pre-eclampsia (PE) risk, but the results are inconsistent among studies. Eligible studies were retrieved in several database. Odds ratios (ORs) with 95% confidence intervals (CIs) were utilised to evaluate the relationship between <i>FOXP3</i> rs3761548, <i>FOXP3</i> rs2232365, <i>CTLA-4</i> rs231775 polymorphisms, and PE susceptibility in the genetic models. The subgroup analysis and trial sequential analysis were performed. Twelve studies with a total of 4658 participants were included. There was a statistically significant association between <i>FOXP3</i> rs3761548 polymorphism and PE within the recessive model in Asian (OR = 0.54, 95% CI = 0.34–0.86<b>)</b>. Trial sequential analysis indicated sufficient proof of such association in the Asian population. This meta-analysis provides sufficient statistical evidence indicating an association between <i>FOXP3</i> rs3761548 polymorphism and PE risk in Asian.IMPACT STATEMENT<b>What is already known on this subject?</b><i>FOXP3</i> and <i>CTLA4</i> are markers of regulatory T cells which play a crucial role during a preeclamptic pregnancy.<b>What do the results of this study add?</b> Eleven studies with a total of 4658 participants were included. There was a statistically significant association between <i>FOXP3</i> rs3761548 polymorphism and pre-eclampsia (PE) within the recessive model in Asian (OR = 0.54, 95% CI = 0.34–0.86<b>)</b>. Trial sequential analysis indicated sufficient proof of such association in the Asian population. However, there was no enough evidence could proof significant association between <i>FOXP3</i> rs2232365 or <i>CTLA-4</i> rs231775 polymorphism and PE.<b>What are the implications of these findings for clinical practice and/or further research?</b> This meta-analysis provides sufficient statistical evidence indicating an association between <i>FOXP3</i> rs3761548 polymorphism and PE risk in Asian. The findings in this study may provide a basis for the further study on <i>FOXP3</i> rs3761548 polymorphism in future research. <b>What is already known on this subject?</b><i>FOXP3</i> and <i>CTLA4</i> are markers of regulatory T cells which play a crucial role during a preeclamptic pregnancy. <b>What do the results of this study add?</b> Eleven studies with a total of 4658 participants were included. There was a statistically significant association between <i>FOXP3</i> rs3761548 polymorphism and pre-eclampsia (PE) within the recessive model in Asian (OR = 0.54, 95% CI = 0.34–0.86<b>)</b>. Trial sequential analysis indicated sufficient proof of such association in the Asian population. However, there was no enough evidence could proof significant association between <i>FOXP3</i> rs2232365 or <i>CTLA-4</i> rs231775 polymorphism and PE. <b>What are the implications of these findings for clinical practice and/or further research?</b> This meta-analysis provides sufficient statistical evidence indicating an association between <i>FOXP3</i> rs3761548 polymorphism and PE risk in Asian. The findings in this study may provide a basis for the further study on <i>FOXP3</i> rs3761548 polymorphism in future research.