cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The digital spotlight: Applying a connective action framework of political protest to global watchdog reporting
Creators: name: Carson, Andrea
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Online First - as at 07/01/2021
© The Author(s) 2020. Digital technologies have transformed advertising markets causing disruption to the funding of traditional media. Yet, paradoxically, the digital age also provides new opportunities for journalism, enabling innovations in investigative reporting on a global scale. However, the transition of investigative journalism from a single newsroom to a multi-newsroom model—involving large-scale transnational collaboration, use of social media networks to extend audience reach and impact, and data journalism to analyze mass data leaks—is understudied. This paper adapts a conceptual framework usually applied to large-scale political protest movements to large-scale collaborative investigative journalism. It aims to show how Lance Bennett and Alexandra Segerberg’s “logic of connective action” can be adapted to understand different forms of networked action such as global collaborative watchdog reporting. Bennett and Segerberg identify three distinct types of large-scale protest formations and this paper contends that these can be approximated to fit different types of large-scale transnational collaborative investigative journalism. Using a case study methodology and interviews with investigative journalists, the article develops a framework to differentiate between types of large-scale investigative collaborations. The framework helps to understand differences between the collaborative investigative reporting efforts of the International Consortium of Investigative Journalists (ICIJ), WikiLeaks, and Edward Snowden’s National Security Agency (NSA) leaks. Taking an interdisciplinary approach, this article seeks to advance theoretical understandings of global watchdog reporting in the digital age.
SupplementalFile1 – Supplemental material for S-plot2: Rapid Visual and Statistical Analysis of Genomic Sequences
Creators: name: Kalesinskas, Laurynas
name: Cudone, Evan
name: Fofanov, Yuriy
name: Putonti, Catherine
Publisher: name: SAGE Journals
Year: 2018
Subjects: Cell Biology

description: Supplemental material, SupplementalFile1 for S-plot2: Rapid Visual and Statistical Analysis of Genomic Sequences by Laurynas Kalesinskas, Evan Cudone, Yuriy Fofanov and Catherine Putonti in Evolutionary Bioinformatics
appendix_r2_(1) – Supplemental material for Identity Sorting and Political Compromise
Creators: name: Davis, Nicholas T.
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 160607 International Relations
subject: FOS: Political science

description: Supplemental material, appendix_r2_(1) for Identity Sorting and Political Compromise by Nicholas T. Davis in American Politics Research
Supplementary Material from Integral equation methods for acoustic scattering by fractals
Creators: name: Caetano, António
name: Chandler-Wilde, Simon
name: Claeys, Xavier
name: Gibbs, Andrew
name: Hewett, David Peter
name: Moiola, Andrea
Publisher: name: The Royal Society
Year: 2024
Subjects: classificationCode: 490199
subject: Applied mathematics not elsewhere classified

description: Supplementary Materials to Integral Equation Methods for Acoustic Scattering by Fractals_final.pdf
Sustained subcutaneous delivery of secretome of human cardiac stem cells promotes cardiac repair following myocardial infarction
Creators: name: Kompa, Andrew R
name: Greening, David
name: Kong, Anne M
name: McMillan, Paul J
name: Fang, Hoayun
name: Saxena, Ritika
name: Wong, Raymond CB
name: Lees, Jarmon G
name: Sivakumaran, Priyadharshini
name: Newcomb, Andrew E
name: Tannous, Bakhos A
name: Kos, Cameron
name: Mariana, Lina
name: Loudovaris, Thomas
name: Hausenloy, Derek J
name: Lim, Shiang Y
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3201
subject: Cardiovascular medicine and haematology

description: Abstract: Aims - To establish pre-clinical proof of concept that sustained subcutaneous delivery of the secretome of human cardiac stem cells (CSCs) can be achieved in vivo to produce significant cardioreparative outcomes in the setting of myocardial infarction.
Methods and results - Rats were subjected to permanent ligation of left anterior descending coronary artery and randomized to receive subcutaneous implantation of TheraCyte devices containing either culture media as control or 1 × 106 human W8B2+ CSCs, immediately following myocardial ischaemia. At 4 weeks following myocardial infarction, rats treated with W8B2+ CSCs encapsulated within the TheraCyte device showed preserved left ventricular ejection fraction. The preservation of cardiac function was accompanied by reduced fibrotic scar tissue, interstitial fibrosis, cardiomyocyte hypertrophy, as well as increased myocardial vascular density. Histological analysis of the TheraCyte devices harvested at 4 weeks post-implantation demonstrated survival of human W8B2+ CSCs within the devices, and the outer membrane was highly vascularized by host blood vessels. Using CSCs expressing plasma membrane reporters, extracellular vesicles of W8B2+ CSCs were found to be transferred to the heart and other organs at 4 weeks post-implantation. Furthermore, mass spectrometry-based proteomic profiling of extracellular vesicles of W8B2+ CSCs identified proteins implicated in inflammation, immunoregulation, cell survival, angiogenesis, as well as tissue remodelling and fibrosis that could mediate the cardioreparative effects of secretome of human W8B2+ CSCs.
Conclusions - Subcutaneous implantation of TheraCyte devices encapsulating human W8B2+ CSCs attenuated adverse cardiac remodelling and preserved cardiac function following myocardial infarction. The TheraCyte device can be employed to deliver stem cells in a minimally invasive manner for effective secretome-based cardiac therapy.
BrethelHaurwitzSupplementalMaterial – Supplemental material for Extraordinary Altruists Exhibit Enhanced Self–Other Overlap in Neural Responses to Distress
Creators: name: Brethel-Haurwitz, Kristin M.
name: Cardinale, Elise M.
name: Kruti M. Vekaria
name: Robertson, Emily L.
name: Walitt, Brian
name: VanMeter, John W.
name: Marsh, Abigail A.
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: Neuroscience

description: Supplemental material, BrethelHaurwitzSupplementalMaterial for Extraordinary Altruists Exhibit Enhanced Self–Other Overlap in Neural Responses to Distress by Kristin M. Brethel-Haurwitz, Elise M. Cardinale, Kruti M. Vekaria, Emily L. Robertson, Brian Walitt, John W. VanMeter and Abigail A. Marsh in Psychological Science
Short-term environmental enrichment is a stronger modulator of brain glial cells and cervical lymph node t cell subtypes than exercise or combined exercise and enrichment
Creators: name: G Singhal
name: Morgan, Julie
name: F Corrigan
name: C Toben
name: MC Jawahar
name: Jaehne, Emily
name: J Manavis
name: AJ Hannan
name: BT Baune
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Physical exercise (PE) and environmental enrichment (EE) can modulate immunity. However, the differential effects of short-term PE, EE, and PE + EE on neuroimmune mechanisms during normal aging has not been elucidated. Hence, a cohort of 3-, 8-, and 13-month-old immunologically unchallenged C57BL/6 wild-type mice were randomly assigned to either Control, PE, EE, or PE + EE groups and provided with either no treatment, a running wheel, a variety of plastic and wooden objects alone or in combination with a running wheel for seven weeks, respectively. Immunohistochemistry and 8-color flow cytometry were used to determine the numbers of dentate gyrus glial cells, and the proportions of CD4 and CD8 T cell numbers and their subsets from cervical lymph nodes, respectively. An increase in the number of IBA1 microglia in the dentate gyrus at 5 and 10 months was observed after EE, while PE and PE + EE increased it only at 10 months. No change in astroglia number in comparison to controls were observed in any of the treatment groups. Also, all treatments induced significant differences in the proportion of specific T cell subsets, i.e., CD4 and CD8 T naïve (T ), central memory (T ), and effector memory (T ) cells. Our results suggest that in the short-term, EE is a stronger modulator of microglial and peripheral T cell subset numbers than PE and PE + EE, and the combination of short-term PE and EE has no additive effects. + + + + + N CM EM
Supplementary_material - Identification of aldo-keto reductase (AKR7A1) and glutathione S-transferase pi (GSTP1) as novel renal damage biomarkers following exposure to mercury
Creators: name: Y-J Shin
name: K-A Kim
name: E-S Kim
name: J-H Kim
name: H-S Kim
name: M Ha
name: O-N Bae
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine

description: Supplementary_material for Identification of aldo-keto reductase (AKR7A1) and glutathione S-transferase pi (GSTP1) as novel renal damage biomarkers following exposure to mercury by Y-J Shin, K-A Kim, E-S Kim, J-H Kim, H-S Kim, M Ha, and O-N Bae in Human & Experimental Toxicology
Additional file 8 of Methods and tools for handling, transportation, weighing, and pelletization applied to the initial analysis of volatile components in the Hayabusa2 samples
Creators: name: Okazaki, Ryuji
name: Yamanouchi, Shinji
name: Shimada, Kazuhiko
name: Baba, Atsushi
name: Kitajima, Fumio
name: Yada, Toru
Publisher: name: figshare
Year: 2024
Subjects: subject: Geochemistry
subject: FOS: Earth and related environmental sciences

description: Additional file 8: Fig. S8 Draws of the metal holder for the sapphire container.
The long and winding road: archiving and re-using qualitative data from 12 research projects spanning 16 years
Creators: name: Dodds, Catherine
name: Keogh, Peter
name: Bourne, Adam
name: McDaid, Lisa
name: Squire, Corinne
name: Weatherburn, Peter
name: Young, Ingrid
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: We describe a pilot project designed to assess the feasibility of re-use across 12 diverse qualitative datasets related to Human Immunodeficiency Virus (HIV) in the UK, from research projects undertaken between 1997 and 2013 – an approach which is chronically underused. First, we consider the sweeping biomedical changes and imperatives relating to HIV in this time frame, offering a rationale for data re-use at this point in the epidemic. We then reflexively situate the processes and procedures we devised for this study with reference to relevant methodological literature. Hammersley’s and Leonelli’s contributions have been particularly instructive through this process, and following their lead, we conclude with further considerations for those undertaking qualitative data re-use, reflecting on the extent to which qualitative data re-use as a practice requires attention to both the given and the constructed aspects of data when assembled as evidence.
Exploring a potential Achilles heel of Mycobacterium tuberculosis: defining the ClpC1 interactome
Creators: name: Dougan, David
name: Alver, Regina
name: Kuersad Turgay
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Protein degradation plays a vital role in the correct maintenance of a cell, not only under normal physiological conditions but also in response to stress. In the human pathogen Mtb, this crucial cellular task is performed by several ATPase associated with diverse cellular activities proteases including ClpC1P. Ziemski et al. performed a bacterial adenylate cyclase two-hybrid screen to identify ClpC1 substrates and showed the Type II TA systems represent a major group of ClpC1-interacting proteins. Comment on: https://doi.org/10.1111/febs.15335.
Supplementary Materials from The effects of isolated game elements on adherence rates in food-based response inhibition training
Creators: name: MacLellan, Alexander
name: Pennington, Charlotte Rebecca
name: Lawrence, Natalia Sophie
name: Westwood, Sam
name: Jones, Andrew
name: Slegrova, Anna
name: Sung, Beatrice
name: Parker, Louise
name: Relph, Luke
name: Miranda, Jessica Oliveira
name: Shakeel, Maryam
name: Mouka, Elizavet
name: Lovejoy, Charlotte
name: Chung, Chaebin
name: Lash, Sabela
name: Suhail, Yusra
name: Nag, Mehr
name: Button, Katherine
Publisher: name: The Royal Society
Year: 2024
Subjects: classificationCode: 529999
subject: Other psychology not elsewhere classified

description: Supplementary_Materials.pdf
INNOVATIVE APPROACHES TO INCLUSIVE TEACHING IN AFFORDABLE EDUCATION SYSTEMS
Creators: name: Olivia, Maria De Santis
Publisher: name: AYDEN JOURNAL
Year: 2025
Subjects: Educational context; Academic achievement; Special pedagogy

description: Even if the term accessibility declined on schools can make us think mainly of infrastructures, accessibility in its most proper sense, as a characteristic of being easily usable by any type of user, fully involves teaching, methodologies and materials that it uses. Practicing inclusive teaching means adopting a real educational orientation, a teaching style that was created to identify and guarantee beneficiaries the optimal learning conditions to smooth out difficulties and differences. The goal is, therefore, to be able to put each student in a position to discover, enhance and express their potential to the fullest, helping to increase school well-being
Alleviation of salinity stress in plants by endophytic plant-fungal symbiosis: Current knowledge, perspectives and future directions
Creators: name: Gupta, S
name: Schillaci, M
name: Walker, R
name: Smith, Penelope
name: Watt, M
name: Roessner, U
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Salinization of soil with sodium chloride ions inhibits plant functions, causing reduction of yield of crops. Salt tolerant microorganisms have been studied to enhance crop growth under salinity. This review describes the performance of endophytic fungi applied to crops as a supplement to plant genetics or soil management to alleviate salt stress in crops. This is achieved via inducing systemic resistance, increasing the levels of beneficial metabolites, activating antioxidant systems to scavenge ROS, and modulating plant growth phytohormones. Colonization by endophytic fungi improves nutrient uptake and maintains ionic homeostasis by modulating ion accumulation, thereby restricting the transport of Na+ to leaves and ensuring a low cytosolic Na+:K+ ratio in plants. Participating endophytic fungi enhance transcripts of genes encoding the high Affinity Potassium Transporter 1 (HKT1) and the inward-rectifying K+ channels KAT1 and KAT2, which play key roles in regulating Na+ and K+ homeostasis. Endophytic-induced interplay of strigolactones play regulatory roles in salt tolerance by interacting with phytohormones. Future research requires further attention on the biochemical, molecular and genetic mechanisms crucial for salt stress resistance requires further attention for future research. Furthermore, to design strategies for sustained plant health with endophytic fungi, a new wave of exploration of plant-endophyte responses to combinations of stresses is mandatory.
Supplemental_Material – Supplemental material for Sexual Sadism Among Sex Offenders in Switzerland
Creators: name: Gonçalves, Leonel C.
name: Rossegger, Astrid
name: Gerth, Juliane
name: Singh, Jay P.
name: Endrass, Jérôme
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, Supplemental_Material for Sexual Sadism Among Sex Offenders in Switzerland by Leonel C. Gonçalves, Astrid Rossegger, Juliane Gerth, Jay P. Singh and Jérôme Endrass in Sexual Abuse: A Journal of Research and Treatment
instructions – Supplemental material for Reconsidering economic leverage and vulnerability: Trade ties, sanction threats, and the success of economic coercion
Creators: name: Peterson, Timothy M
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 220104 Human Rights and Justice Issues
subject: FOS: Philosophy, ethics and religion
subject: 160607 International Relations
subject: FOS: Political science

description: Supplemental material, instructions for Reconsidering economic leverage and vulnerability: Trade ties, sanction threats, and the success of economic coercion by Timothy M Peterson in Conflict Management and Peace Science
Additional file 1 of The effectiveness of e-mental health interventions on stress, anxiety, and depression among healthcare professionals: a systematic review and meta-analysis
Creators: name: Zhang, Zemiao
name: Hu, Yinhuan
name: Liu, Sha
name: Feng, Xiandong
name: Yang, Jinhong
name: Cheng, Ling Jie
name: Ramazanu, Sheena
name: Wu, Xi Vivien
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Additional file 1: Supplementary Table S1. PRISMA checklist. Supplementary Table S2. Search terms of databases. Supplementary Table S3. Eligibility criteria. Supplementary Table S4. Data extraction table. Supplementary Table S5. Characteristics of included studies. Supplementary Table S6. Description of e-mental health intervention. Supplementary Table S7. Summary of Findings table. Supplementary Figure S1. Risk of bias within studies summary. Supplementary Figure S2. Funnel plot of stress. Supplementary Figure S3. Funnel plot of anxiety.
Supplementary_Material_R2.2 – Supplemental material for Improved Wald Statistics for Item-Level Model Comparison in Diagnostic Classification Models
Creators: name: Liu, Yanlou
name: Andersson, Björn
name: Xin, Tao
name: Zhang, Haiyan
name: Wang, Lingling
Publisher: name: SAGE Journals
Year: 2018
Subjects: Sociological Methodology and Research Methods
Psychology not elsewhere classified

description: Supplemental material, Supplementary_Material_R2.2 for Improved Wald Statistics for Item-Level Model Comparison in Diagnostic Classification Models by Yanlou Liu, Björn Andersson, Tao Xin, Haiyan Zhang and Lingling Wang in Applied Psychological Measurement
Running after cycling induces inter-limb differences in muscle activation but not in kinetics or kinematics
Creators: name: Jacques, Tiago
name: Rico-Bini, Rodrigo
name: Arndt, Anton
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Overuse injuries are a common problem to triathletes’ population. Overuse injuries may arise from inter-limb biomechanical differences during running, but the literature lacks information regarding inter-limb differences in triathletes. In this study inter-limb differences were investigated in injury-free triathletes during the running portion of a simulated cycle-run transition. Thirteen triathletes performed a 5 km run preceded by a 20 min cycling trial at 70% of maximal power output. During the Start, Mid and End stages of running, kinetic, kinematic and muscle activation variables were compared between the preferred and non-preferred limbs across the stance phase. A statistical parametric mapping analysis showed no differences between limbs when considering kinetic and kinematic variables (p > 0.05, ES<0.60). A lower soleus activation was observed in the preferred limb (p 0.60) from 53.40–75.9% of the stance phase at the End stage of running. In conclusion, inter-limb differences in kinetic or kinematic variables may not represent a risk for overloading in triathletes. However, inter-limb differences in triceps surae activation during running after cycling may represent one potential factor leading to overuse injuries in triathletes and should be further investigated.
La castanicoltura nelle valli superiori del Ticino tra il tardo medioevo e l?inizio dell?epoca contemporanea
Creators: name: LAURIANTI, FEDERICO
Publisher: name: Universit� degli studi di Genova
Year: 2019

description: This thesis analyses the chestnut cultivation and its importance in the Alpine valleys in the current Swiss region of Tessin. The research has a historical and comparative perspective to reconstruct the geographical, social and economic role of chestnuts as a resource for the inhabitants of this region during a period starting from the Middle Ages to the first half of the XX century, when the ?chestnut civilization? came to an end. The approach to these topics has been conducted with a methodology mainly based on historical geography and local history. In this work the reference to different sources took on particular importance. Most of these are not published and stem mostly from local archives, as the old descriptive cadastres, jus plantandi registers, notarial acts and local statutes. The sources on the lands and their inspections, both considered very important and useful, completed in a less systemic way the range of the sources of reference. All these references are linked and crossed as in a network, while trying to understand the multiple influences that affected the regional chestnut growing, as a part of an open and unsteady system. Analysing in this way the sources, comparing them and referring to other regions? similar studies, it has been possible to qualify and quantify the role of the chestnut between the XIV and the XX centuries and recognise its strong importance, although it is possible to claim that to the life of the inhabitants of the southern Swiss Alps the chestnut was probably less crucial than it was to the people living in the Italian mountain regions of the Apennines in the same periods.
In silico comparison of SARS‑CoV‑2 spike protein‑ACE2 binding affinities across species and implications for virus origin
Creators: name: Piplani, Sakshi
name: Singh, Puneet
name: Winkler, David
name: Petrovsky, Nikolai
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: The devastating impact of the COVID-19 pandemic caused by SARS–coronavirus 2 (SARS-CoV-2) has raised important questions about its origins and the mechanism of its transfer to humans. A further question was whether companion or commercial animals could act as SARS-CoV-2 vectors, with early data suggesting susceptibility is species specific. To better understand SARS-CoV-2 species susceptibility, we undertook an in silico structural homology modelling, protein–protein docking, and molecular dynamics simulation study of SARS-CoV-2 spike protein’s ability to bind angiotensin converting enzyme 2 (ACE2) from relevant species. Spike protein exhibited the highest binding to human (h)ACE2 of all the species tested, forming the highest number of hydrogen bonds with hACE2. Interestingly, pangolin ACE2 showed the next highest binding affinity despite having a relatively low sequence homology, whereas the affinity of monkey ACE2 was much lower despite its high sequence similarity to hACE2. These differences highlight the power of a structural versus a sequence-based approach to cross-species analyses. ACE2 species in the upper half of the predicted affinity range (monkey, hamster, dog, ferret, cat) have been shown to be permissive to SARS-CoV-2 infection, supporting a correlation between binding affinity and infection susceptibility. These findings show that the earliest known SARS-CoV-2 isolates were surprisingly well adapted to bind strongly to human ACE2, helping explain its efficient human to human respiratory transmission. This study highlights how in silico structural modelling methods can be used to rapidly generate information on novel viruses to help predict their behaviour and aid in countermeasure development.
Supplemental Material, DS1_VET_10.1177_0300985818794262 - Sarcocystis calchasi Outbreak in Feral Rock Pigeons (Columba livia) in California
Creators: name: Aslı Mete
name: Rogers, Krysta H.
name: Wolking, Rebecca
name: Bradway, Daniel S.
name: Kelly, Terra
name: Piazza, Melanie
name: Crossley, Beate
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine
subject: 70706 Veterinary Medicine
subject: FOS: Veterinary sciences

description: Supplemental Material, DS1_VET_10.1177_0300985818794262 for Sarcocystis calchasi Outbreak in Feral Rock Pigeons (Columba livia) in California by Aslı Mete, Krysta H. Rogers, Rebecca Wolking, Daniel S. Bradway, Terra Kelly, Melanie Piazza, and Beate Crossley in Veterinary Pathology
PTHD_Descriptive – Supplemental material for Selective or collective? Palestinian perceptions of targeting in house demolition
Creators: name: Hatz, Sophia
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 220104 Human Rights and Justice Issues
subject: FOS: Philosophy, ethics and religion
subject: 160607 International Relations
subject: FOS: Political science

description: Supplemental material, PTHD_Descriptive for Selective or collective? Palestinian perceptions of targeting in house demolition by Sophia Hatz in Conflict Management and Peace Science
OnlineAppendix_CD-CAT_MCDINA_R2 – Supplemental material for Computerized Adaptive Testing for Cognitively Based Multiple-Choice Data
Creators: name: Hulya D. Yigit
name: Sorrel, Miguel A.
name: Torre, Jimmy De La
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, OnlineAppendix_CD-CAT_MCDINA_R2 for Computerized Adaptive Testing for Cognitively Based Multiple-Choice Data by Hulya D. Yigit, Miguel A. Sorrel and Jimmy de la Torre in Applied Psychological Measurement
LNG as the future marine fuel, Waste Heat Recovery Systems & Cold Ironing solutions for eco-friendly maritime transport
Creators: name: LAVIOLA, MICHELE
Publisher: name: Universit� degli studi di Genova
Year: 2018

description: Nowadays a regulatory framework regarding the pollutant emissions abatement, both at international
and local level, significantly interests the maritime sector. To comply with the latest environmental
rules, a new approach to ship design and a renewed way to operate the ship are need both in
navigation and in harbour. This PhD Thesis aims to investigate on the positive features offered by the
LNG fuel, more eco-friendly than the traditional marine fuel oils. In the first part of the research, the
performance comparison between two marine engines, fuelled by natural gas and diesel oil
respectively is reported. Two different simulation codes, one for each engine, validated by means of
geometrical and performance data provided by the manufacturer have been developed to extend the
comparison to the whole working area of the examined engines. In the second part of the research, a
LNG-repowering study of a cruise ferry is presented. The study is enhanced by the investigation on
possible Waste Heat Recovery (WHR) systems aiming at the reduction of Green House Gas (GHG),
pollution, and money saving. A computational code has been developed to carry out the sizing and to
analyse the energetic performance and economical aspects of the several examined WHR layout
systems. The more eco-friendly layout for the considered ship is proposed to comply with in force
rules. The third part of the PhD Thesis is focused on studying some maritime technical solutions for
the electric energy generation and delivery to ships moored in port, by means of LNG fuelled
generators installed on board a floating unit. Two different scenarios, regarding the LNG supply
chain, are considered and some options for producing cleaner electric energy are then investigated.
The reference area examined in this study is the old port of Genoa, where the traffic of both
passenger and cargo ships takes place. The analysis is carried out by means of a MATLAB numerical
code to calculate the most important features of the floating unit, as dimensions and weights and the
most significant characteristics of the electric generation equipment, as the average load factor, fuel
consumption and energy cost. From an economical point of view, the externalities costs abatement,
thanks to the technical solution proposed are investigated. The study also focuses on the estimation of
governmental incentives to promote and sustain the use of the proposed power supply barge, resulting
into a fully positive technical solution.
Supplemental material for Chitosan enhances gene delivery of oligonucleotide complexes with magnetic nanoparticles–cell-penetrating peptide
Creators: name: Moataz Dowaidar
name: Abdelhamid, Hani Nasser
name: Hällbrink, Mattias
name: Langel, Ülo
name: Xiaodong Zou
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental Material for Chitosan enhances gene delivery of oligonucleotide complexes with magnetic nanoparticles–cell-penetrating peptide by Moataz Dowaidar, Hani Nasser Abdelhamid, Mattias Hällbrink, Ülo Langel and Xiaodong Zou in Journal of Biomaterials Applications
Additional file 1 of Exploring the tradeoff between data privacy and utility with a clinical data analysis use case
Creators: name: Im, Eunyoung
name: Kim, Hyeoneui
name: Lee, Hyungbok
name: Jiang, Xiaoqian
name: Kim, Ju Han
Publisher: name: figshare
Year: 2024
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Supplementary Material 1
Supplemental material for Carrageenan hydrogel as a scaffold for skin-derived multipotent stromal cells delivery
Creators: name: Rode, Michele Patricia
name: Addeli Bez Batti Angulski
name: Gomes, Felipe Azevedo
name: Maiara Marques Da Silva
name: Talita Da Silva Jeremias
name: Carvalho, Rafael Guzella De
name: Vieira, Daniel Gonçalves Iucif
name: Luiz Fernando Cappa Oliveira
name: Lenize Fernandes Maia
name: Trentin, Andrea Gonçalves
name: Hayashi, Leila
name: Kildare Rocha De Miranda
name: Aguiar, Adriano Kopke De
name: Rosa, Rafael Diego
name: Calloni, Giordano Wosgrau
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental Material for Carrageenan hydrogel as a scaffold for skin-derived multipotent stromal cells delivery by Michele Patricia Rode, Addeli Bez Batti Angulski, Felipe Azevedo Gomes, Maiara Marques da Silva, Talita da Silva Jeremias, Rafael Guzella de Carvalho, Daniel Gonçalves Iucif Vieira, Luiz Fernando Cappa Oliveira, Lenize Fernandes Maia, Andrea Gonçalves Trentin, Leila Hayashi, Kildare Rocha de Miranda, Adriano Kopke de Aguiar, Rafael Diego Rosa and Giordano Wosgrau Calloni in Journal of Biomaterials Applications
Development of discoidal polymeric nanoconstructs for the treatment of cancer disease
Creators: name: FELICI, ALESSIA
Publisher: name: Universit� degli studi di Genova
Year: 2021

description: High loading and specific release of therapeutic agents within the tumor microenvironment are key factors in the development of novel nano-based therapeutic systems against cancer. Although drug availability and preferential tumor accumulation improved with advanced drug delivery system for cancer therapy, they still faces challenge in drug encapsulation and retention. Here, Discoidal Polymeric Nanoconstructs (DPNs) were employed to load and systemically deliver both hydrophilic and hydrophobic therapeutic molecules. DPNs appear as disks, with a diameter of about 1 �m and a height of 400 nm, designed for vascular adhesion in a tortuous and low perfused vasculature as in the case of tumor. Moreover, soft DPNs presenting a stiffness of about few kPa, were shown to circulate longer, more effectively avoid the sequestration by hepatic and splenic immune cells and accumulate at higher doses in the tumor vasculature as compared to rigid DPNs. DPNs were synthetized by mixing together hydrophobic ? poly(lactic-co-glycolic acid) (PLGA) and hydrophilic ? polyethylene glycol diacrylate (PEG-diacrylate) using a top-down, template-based fabrication process. Improved performance in terms of encapsulation efficiency and drug retention have been achieved following two approaches; first, improving the fabrication process with a multi-passage strategy over the hydrophilic PVA template used for DPN production; Second, modulating the chemical proprieties of the selected drug Docetaxel by lipid or polymeric chains conjugation. In particular, two different prodrugs were realized, namely oleic-Docetaxel (O-DTXL) and PEG-Docetaxel (PEG-DTXL) incorporated in DPN via direct and absorption loading. On one side, the conjugation of Dtxl with PEG chains ensures an improved loading efficiency and retention capability of the drug within the soft polymeric net respect to the Docetaxel alone. In cell-line orthotopic brain cancer model, with only 1 mg/kg of drug administered intravenously every other days for 20 days post resection of the primary mass, DTXL-PEG550-DPNs increase the median overall survival (?30 days) as compared also to 10 chemotherapeutic cycles with temozolomide administered at a dose three times higher (3mg/Kg) (27 days).On the other side, multi-passage DTXL-DPNs efficiently accumulated in In orthotopic murine models of Triple negative breast cancer masses with a tumor-to-abdomen ratio of 1.3. With only 2 mg/kg of DTXL, intravenously administered every other day for 13 times, DTXL-DPNs induced tumor regression returning an 80% survival rate at 120 days as compared to 30% with free DTXL. Collectively, these results demonstrate that vascular targeting nanoconstructs with tunable pharmacological properties can be exploited to effectively treat multiples type of tumors.
Additional file 1 of Integrating network pharmacology, bioinformatics, and experimental validation to unveil the molecular targets and mechanisms of galangin for treating hepatocellular carcinoma
Creators: name: Li, Xiaoliang
name: Zhou, Mingyan
name: Chen, Weijia
name: Sun, Jiangbo
name: Zhao, Yihang
name: Wang, Gaoan
name: Wang, Bingshu
name: Pan, Yipeng
name: Zhang, Junqing
name: Xu, Jian
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Supplementary Material 1
Exploring the Structure-Property Relationship of Magnesium Dissolution Modulators
Creators: name: Winkler, David
name: Würger, Tim
name: D Mei
name: B Vaghefinazari
name: Lamaka, Sviatlana
name: M Zheludkevich
name: R Meißner
name: Feiler, Christian
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: https://www.nature.com/articles/s41529-020-00148-zAbstract: Small organic molecules that modulate the degradation behavior of Mg constitute benign and useful materials to modify the service environment of light metal materials for specific applications. The vast chemical space of potentially effective compounds can be explored by machine learning-based quantitative structure-property relationship models, accelerating the discovery of potent dissolution modulators. Here, we demonstrate how unsupervised clustering of a large number of potential Mg dissolution modulators by structural similarities and sketch-maps can predict their experimental performance using a kernel ridge regression model. We compare the prediction accuracy of this approach to that of a prior artificial neural networks study. We confirm the robustness of our data-driven model by blind prediction of the dissolution modulating performance of 10 untested compounds. Finally, a workflow is presented that facilitates the automated discovery of chemicals with desired dissolution modulating properties from a commercial database. We subsequently prove this concept by blind validation of five chemicals.
Parent engagement in perinatal mortality reviews: an online survey of clinicians from six high-income countries
Creators: name: Boyle, FM
name: Horey, Dell
name: Siassakos, D
name: Burden, C
name: Bakhbakhi, D
name: Silver, RM
name: Flenady, V
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: No description supplied
Characterization of the Kidins220 CaMKIICre conditional KO mouse line
Creators: name: ALMACELLAS BARBANOJ, AMANDA
Publisher: name: Universit� degli studi di Genova
Year: 2019

description: Kidins220 (Kinase-D interacting substrate of 220 kDa) is a scaffold transmembrane
protein abundantly expressed in the nervous system. Mutations in the KIDINS220
gene have been correlated with psychiatric disorders and with the recently described
SINO syndrome, characterized by spastic paraplegia, intellectual disability, syntagmus
and obesity. Kidins220 is involved in several neuronal functions regulated by
neurotrophic factors, including neuronal survival, differentiation and synaptic plasticity.
Previous work with the complete KO mouse model for Kidins220 evidenced
the crucial role of this protein in neuronal and cardiovascular development since its
embryonic ablation is lethal. Thus to gain a comprehensive understanding of the
role of Kidins220 in the adult mouse, a Cre/loxP based conditional KO (cKO) mouse
model was generated, in which the Ca2+/ Calmodulin-dependent kinase-II (CaMKII)
promoter drives Cre expression, and consequently protein deletion specifically in the
postnatal forebrain. The characterization of the Kidins220 cKO model has been accomplished
through diverse approaches: behavioural experiments, brain and neuron
morphological analysis, molecular signalling from brain slices and cultures, protein
and gene expression assessment. cKO mice display alterations in anxiety levels and
social behaviour, with a clear impairment in social memory. At the morphological
level, data show reduced dendritic branching in cortical and hippocampal neurons,
while at the molecular level, neuronal response to brain-derived neurotrophic factor
(BDNF) stimulation is blunted, as well as the mitogen-activated protein kinase
(MAPK) pathway activation. The behavioural profile of these animals provides useful
knowledge about the pathophysiology of Kidins220, indicating that alterations of
this protein expression may have important consequences on human pathologies
of the cognitive and social sphere. Some psychiatric diseases are highly inheritable,
and their causes have been traced back to genetic alterations such as point
mutations and epigenetic modifications. A better understanding of such inheritable
traits will provide us with a better knowledge of the cellular and physiological alterations
underlying the behavioural and cognitive symptomatology of patients. In this
respect, the knowledge of Kidins220 function will contribute to further elucidate the
neuropathological mechanisms underlying some psychiatric diseases.
Global intergovernmental initiatives to minimise alcohol problems: Some good intentions, but little action
Creators: name: Room, Robin
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: While, historically, alcohol production and sale were local matters, commercialised and industrialised alcohol has supervened, globalised initially through European empires, transforming alcohol's place in everyday life. But alcohol was not included in the current international drug control system, initiated in 1912. In the current UN system of 35 intergovernmental agencies, alcohol has been a recurrent concern in the work only of the World Health Organization (WHO). Examples are given of the sporadic involvement in alcohol issues of other agencies, and the history of WHO's involvement between 1950 and early 2020 is briefly described. At WHO, the place of alcohol programming in its structure and which other topics it is linked with have been recurrent issues. Civil society support for alcohol initiatives has been comparatively weak, and alcohol industry counter-pressure has been strong. Alcohol issues have thus received less attention at the intergovernmental level than the harm would justify. Constraining factors have included not only lobbying by industry interests, but also the multi-sectoral nature of alcohol problems and the international cultural position of alcohol as a luxury good served at gatherings of political and media elites.
supplementary_Material – Supplemental material for How is sexuality after stroke experienced by stroke survivors and partners of stroke survivors? A systematic review of qualitative studies
Creators: name: McGrath, Margaret
name: Lever, Sandra
name: McCluskey, Annie
name: Power, Emma
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 110314 Orthopaedics
subject: 110604 Sports Medicine
subject: FOS: Health sciences

description: Supplemental material, supplementary_Material for How is sexuality after stroke experienced by stroke survivors and partners of stroke survivors? A systematic review of qualitative studies by Margaret McGrath, Sandra Lever, Annie McCluskey and Emma Power in Clinical Rehabilitation
Accounting and work in charities: the case of an Italian institution in the 19th century
Creators: name: Nicoliello, Mario
name: Jalali Aliabadi, Farzaneh
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 35
subject: Commerce, management, tourism and services
classificationCode: 3501
subject: Accounting, auditing and accountability
classificationCode: 3503
subject: Business systems in context
classificationCode: 350304
subject: Business systems in context
classificationCode: 3505
subject: Human resources and industrial relations
classificationCode: 3507
subject: Strategy, management and organisational behaviour

description: This research examines the processes of transformation of accounting systems as well as the activity and work of an ancient Italian charity titled the Congrega of the Apostolic Charity (the Congrega) from 1860 to 1886. During this period, various events occurred, such as changes in institutional activities as well as changes in the actors and accounting practices. The results of this study highlight the transition in accounting practices and reports caused by changes in the business of charities, and also how new rules and routines are institutionalised. We show that the changes in the composition of human resource – and the associated costs and reporting – are institutionalised following the changes in activities of the Congrega. We argue that the accounting transition in the Congrega, led by social and political changes, can be explained using an institutional framework, by the changes that occurred in the context.
Supplemental Material, SPPS722834_suppl_mat - Wanting to Stay and Wanting to Go: Unpacking the Content and Structure of Relationship Stay/Leave Decision Processes
Creators: name: Joel, Samantha
name: MacDonald, Geoff
name: Page-Gould, Elizabeth
Publisher: name: SAGE Journals
Year: 2017
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental Material, SPPS722834_suppl_mat for Wanting to Stay and Wanting to Go: Unpacking the Content and Structure of Relationship Stay/Leave Decision Processes by Samantha Joel, Geoff MacDonald, and Elizabeth Page-Gould in Social Psychological and Personality Science
MOLECULAR HETEROGENEITY AND PROGNOSTIC IMPLICATIONS OF SYNCHRONOUS ADVANCED COLORECTAL NEOPLASIA
Creators: name: BASSO, GIANLUCA
Publisher: name: Universit� degli Studi di Milano
Year: 2013

description: Introduzione e scopo. In letteratura molte ipotesi sono state formulate sull?insorgenza dei tumori sincroni del colon retto (S-CRC). Infatti, non � ancora del tutto chiaro se questo tipo di malattia sviluppa attraverso un particolare pathway molecolare legato ad una elevata suscettibilit� della mucosa colica a divenire neoplastica e se a livello clinico evidenzia una prognosi peggiore. Dal momento che i tumori con instabilit� dei microsatelliti (MSI) possono costituire un bias nel valutare la presenza di metilazione e l?andamento clinico dei S-CRC, abbiamo analizzato per neoplasia sincrona e per disease-specific survival (DSS), una ampia casistica di CRC caratterizzata per la mutazione di BRAF e per lo stato dei microsatelliti. Pazienti e Metodi. Nello studio sono stati arruolati 881 pazienti consecutivi, i quali sono stati sottoposti a resezione del cancro del colon e hanno eseguito a livello perioperatorio una colonscopia completa. Per ogni paziente, i dati demografici e clinico-patologici sono stati recuperati e il DSS � stato valutato in modo retrospettivo. Tutti i tumori sono stati sottoposti a screening per MSI, per identificare pazienti con HNPCC, mediante l?analisi di marcatori mononucleotidici come BAT 26 e BAT25. Nei tumori con instabilit� dei microsatelliti, il difetto proteico � stato individuato mediante immunoistochimica (IHC) e successivamente sono stati testati per la mutazione germinale del gene corrispondente. Inoltre, tutti i tumori sono stati anche analizzati per la mutazione di BRAF c.1799T> A. Risultati. Il S-CRC � stato associato con lo stadio IV (p = 0.01) e con l?HNPCC (p <0.001), ma solo i casi MSS S-CRC sono pi� frequentemente metastatici (p = 0.001). La mutazione di BRAF c.1799T> A era associata con gli MSI CRC sporadici (p <0.001), ma non con i S-CRC (p = 0.96). I cancri sincroni non cambiano il miglior DSS dei pazienti con MSI CRC (HR 0.74, 95% CI 0.09-5.75, p = 0.77). Viceversa, i MSS S-CRC (HR 1.82, 95% CI 1.15-2.87, p = 0.01), cos� come un tumore MSS e la presenza di un adenoma avanzato (sincrono adenoma avanzato) (HR 1.81, 95% CI 1.27-2.58, p = 0.001), e la mutazione di BRAF c.1799T> A (HR 2.16, 95% CI 1.25-3.73, p = 0.01) risultano essere variabili predittori di un aumentato rischio di morte indipendenti dallo stadio di malattia. Conclusioni. I MSS S-CRC evidenziano una prognosi peggiore, e lo stesso vale per la presenza di un sincrono adenoma avanzato. Dallo studio emerge che n� la presenza di multiple avanzate neoplasie in tumori MSS n� la loro maggiore aggressivit� sono mediati da un effetto epigenetico. Per cui la sorveglianza e i protocolli terapeutici per i pazienti con un MSS CRC dovrebbero tener conto del peso prognostico dato dalla presenza di neoplasie sincrone avanzate del colon-retto.
Supplemental Material, SPPS720273_suppl_mat - Comparing a Variable-Centered and a Person-Centered Approach to the Structure of Prejudice
Creators: name: Meeusen, Cecil
name: Meuleman, Bart
name: Abts, Koen
name: Bergh, Robin
Publisher: name: SAGE Journals
Year: 2017
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental Material, SPPS720273_suppl_mat for Comparing a Variable-Centered and a Person-Centered Approach to the Structure of Prejudice by Cecil Meeusen, Bart Meuleman, Koen Abts, and Robin Bergh in Social Psychological and Personality Science
Supplemental Material, Appendix_(1) - How to Sell a Coup: Elections as Coup Legitimation
Creators: name: Grewal, Sharan
name: Kureshi, Yasser
Publisher: name: SAGE Journals
Year: 2018
Subjects: subject: 220104 Human Rights and Justice Issues
subject: FOS: Philosophy, ethics and religion
subject: 160607 International Relations
subject: FOS: Political science

description: Supplemental Material, Appendix_(1) for How to Sell a Coup: Elections as Coup Legitimation by Sharan Grewal, and Yasser Kureshi in Journal of Conflict Resolution