title: ÐÐ½ÑÐ¾Ð³ÐµÐ½ÐµÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð°ÑÐ¿ÐµÐºÑÑ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ ÐºÑÑÑ Ñ Ð³ÐµÐ½ÐµÑÐ¸ÑÐµÑÐºÐ¸ Ð´ÐµÑÐµÑÐ¼Ð¸Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐ¼ Ð½Ð°ÑÑÑÐµÐ½Ð¸ÐµÐ¼ Ð¾Ð±Ð¼ÐµÐ½Ð° Ð´Ð¾ÑÐ°Ð¼Ð¸Ð½Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Ontogenetic aspects of the development of rats with a genetically determined disorder of dopamine metabolism
Creators: name: ÐÐ°Ð·Ð°ÑÐ¾Ð², ÐÐ»ÑÑ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: Ð´Ð¾ÑÐ°Ð¼Ð¸Ð½
ÑÐ´Ð²Ð³
dat-ko
Ð¾Ð½ÑÐ¾Ð³ÐµÐ½ÐµÐ·
ÑÐ½Ñ
dopamine
adhd
ontogenesis
cns

description: Ð¡Ð¸Ð½Ð´ÑÐ¾Ð¼ Ð´ÐµÑÐ¸ÑÐ¸ÑÐ° Ð²Ð½Ð¸Ð¼Ð°Ð½Ð¸Ñ Ð¸ Ð³Ð¸Ð¿ÐµÑÐ°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ (Ð¡ÐÐÐ) â ÑÐ»Ð¾Ð¶Ð½Ð¾Ðµ Ð³ÐµÑÐµÑÐ¾Ð³ÐµÐ½Ð½Ð¾Ðµ ÑÐ°ÑÑÑÑÐ¾Ð¹ÑÑÐ²Ð¾, Ð¿ÑÐ¾ÑÐ²Ð»ÑÑÑÐµÐµÑÑ Ð² Ð´ÐµÑÑÑÐ²Ðµ. Ð Ð°Ð½ÐµÐµ Ð² Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸ÑÑ Ð±ÑÐ»Ð° Ð¿Ð¾ÐºÐ°Ð·Ð°Ð½Ð° ÑÐ²ÑÐ·Ñ Ð¼ÐµÐ¶Ð´Ñ Ð¡ÐÐÐ Ð¸ Ð³ÐµÐ½Ð¾Ð¼, ÐºÐ¾Ð´Ð¸ÑÑÑÑÐ¸Ð¼ Ð±ÐµÐ»Ð¾Ðº Ð´Ð¾ÑÐ°Ð¼Ð¸Ð½Ð¾Ð²Ð¾Ð³Ð¾ ÑÑÐ°Ð½ÑÐ¿Ð¾ÑÑÐµÑÐ° DAT. ÐÐ¾ÑÑÐ¾Ð¼Ñ Ð² ÐºÐ°ÑÐµÑÑÐ²Ðµ Ð¼Ð¾Ð´ÐµÐ»ÑÐ½ÑÑ Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑ Ð¿ÑÐ¸ Ð¸Ð·ÑÑÐµÐ½Ð¸Ð¸ Ð¡ÐÐÐ Ð²ÑÑÑÑÐ¿Ð°ÑÑ ÐºÑÑÑÑ DAT-KO, Ð¸Ð¼ÐµÑÑÐ¸Ðµ Ð½Ð¾ÐºÐ°ÑÑ Ð´Ð¾ÑÐ°Ð¼Ð¸Ð½Ð¾Ð²Ð¾Ð³Ð¾ ÑÑÐ°Ð½ÑÐ¿Ð¾ÑÑÐµÑÐ°. ÐÐ½Ð¸Â  Ð¿ÑÐ¾ÑÐ²Ð»ÑÑÑ Ð³Ð¸Ð¿ÐµÑÐ°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ, Ð´ÐµÑÐ¸ÑÐ¸Ñ Ð²Ð½Ð¸Ð¼Ð°Ð½Ð¸Ñ Ð¸ Ð¸Ð¼Ð¿ÑÐ»ÑÑÐ¸Ð²Ð½Ð¾Ðµ Ð¿Ð¾Ð²ÐµÐ´ÐµÐ½Ð¸Ðµ. ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð´Ð¸Ð½Ð°Ð¼Ð¸ÐºÐ¸ ÑÐ¾Ð·ÑÐµÐ²Ð°Ð½Ð¸Ñ Ð½ÐµÑÐ²Ð½Ð¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ Ñ Ð¿Ð¾ÑÐ¾Ð¼ÑÑÐ²Ð° ÐºÑÑÑ Ð»Ð¸Ð½Ð¸Ð¸ DAT-KO Ð¿ÑÐ¸ Ð¸Ñ ÐµÑÑÐµÑÑÐ²ÐµÐ½Ð½Ð¾Ð¼ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ð¸. ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸Ð»Ð¾ÑÑ Ð½Ð° ÐºÑÑÑÑÑÐ°Ñ Ñ Ð³ÐµÐ½Ð¾ÑÐ¸Ð¿Ð°Ð¼Ð¸ DAT-KO, HET (Ð³ÐµÑÐµÑÐ¾Ð·Ð¸Ð³Ð¾ÑÐ° Ð¿Ð¾ Ð½Ð¾ÐºÐ°ÑÑÑ Ð³ÐµÐ½Ð° DAT) Ð¸ WT (Ð´Ð¸ÐºÐ¸Ð¹ ÑÐ¸Ð¿). ÐÐ° Ð¿ÐµÑÐ²Ð¾Ð¹ Ð½ÐµÐ´ÐµÐ»Ðµ Ð¶Ð¸Ð·Ð½Ð¸ ÐºÑÑÑÑÑÐ° DAT-KO Ð¿ÑÐ¾ÑÐ²Ð»ÑÐ»Ð¸ Ð¿Ð¾Ð²ÑÑÐµÐ½Ð½ÑÑ Ð»Ð¾ÐºÐ¾Ð¼Ð¾ÑÐ¾ÑÐ½ÑÑ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ, ÑÑÐ¾ Ð±ÑÐ»Ð¾ Ð½Ð°Ð¼Ð¸ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð½Ð¾ Ð² ÑÐµÑÑÐµ Â«Ð¼Ð°ÑÑÐ½Ð¸ÐºÐ¾Ð²ÑÐ¹ ÑÐµÑÐ»ÐµÐºÑÂ». ÐÐ¾ÑÐ»Ðµ Ð²ÑÐ¾ÑÐ¾Ð¹ Ð½ÐµÐ´ÐµÐ»Ð¸ Ð¶Ð¸Ð·Ð½Ð¸ ÑÐµÑÑÑ, Ð¾ÑÐµÐ½Ð¸Ð²Ð°ÑÑÐ¸Ðµ ÑÐµÐ½ÑÐ¾ÑÐ½Ð¾-Ð¼Ð¾ÑÐ¾ÑÐ½ÑÐµ ÑÐµÑÐ»ÐµÐºÑÑ, Ð½Ðµ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð»Ð¸ Ð·Ð½Ð°ÑÐ¸Ð¼ÑÑ Ð¾ÑÐ»Ð¸ÑÐ¸Ð¹. ÐÑÐ»Ð¾ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð½Ð¾, ÑÑÐ¾ ÐºÑÑÑÑÑÐ° DAT-KO Ð¸ HET Ð±ÑÑÑÑÐµÐµ Ð½Ð°Ð±Ð¸ÑÐ°ÑÑ Ð²ÐµÑ Ð² ÑÐµÑÐµÐ½Ð¸Ðµ Ð¿ÐµÑÐ²ÑÑ Ð´Ð²ÑÑ Ð½ÐµÐ´ÐµÐ»Ñ Ð¶Ð¸Ð·Ð½Ð¸. ÐÐ° 30 Ð´ÐµÐ½Ñ ÑÐ°Ð·Ð»Ð¸ÑÐ¸Ð¹ Ð½Ðµ Ð½Ð°Ð±Ð»ÑÐ´Ð°Ð»Ð¾ÑÑ Ð½Ð¸ Ð² ÑÐ¸Ð·Ð¸ÑÐµÑÐºÐ¾Ð¼ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ð¸, Ð½Ð¸ Ð² Ð¿Ð¾Ð²ÐµÐ´ÐµÐ½Ð¸Ð¸ (ÑÐµÑÑ Â«Ð¾ÑÐºÑÑÑÐ¾Ðµ Ð¿Ð¾Ð»ÐµÂ»). Ð¡Ð¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸Ðµ Ð±Ð¸Ð¾Ð³ÐµÐ½Ð½ÑÑ Ð¼Ð¾Ð½Ð¾Ð°Ð¼Ð¸Ð½Ð¾Ð² Ð² ÑÐ°ÐºÐ¸Ñ ÑÑÑÑÐºÑÑÑÐ°Ñ ÐºÐ°Ðº ÑÑÑÐ¸Ð°ÑÑÐ¼, Ð¿ÑÐµÑÑÐ¾Ð½ÑÐ°Ð»ÑÐ½Ð°Ñ, ÑÐ½ÑÐ¾ÑÐ¸Ð½Ð°Ð»ÑÐ½Ð°Ñ, Ð¼Ð¾ÑÐ¾ÑÐ½Ð°Ñ ÐºÐ¾ÑÐ°, Ð³Ð¸Ð¿Ð¿Ð¾ÐºÐ°Ð¼Ð¿ Ð¸ Ð¼Ð¾Ð·Ð¶ÐµÑÐ¾Ðº Ð² ÑÐ°Ð½Ð½ÐµÐ¼ Ð¿Ð¾Ð´ÑÐ¾ÑÑÐºÐ¾Ð²Ð¾Ð¼ Ð¿ÐµÑÐ¸Ð¾Ð´Ðµ Ñ ÐºÑÑÑÑÑ DAT-KO Ð¸ HET Ð½Ðµ Ð¾ÑÐ»Ð¸ÑÐ°ÐµÑÑÑ Ð¾Ñ WT, ÑÑÐ¾ Ð¼Ð¾Ð¶ÐµÑ Ð³Ð¾Ð²Ð¾ÑÐ¸ÑÑ Ð¾ Ð½Ð¾ÑÐ¼Ð°Ð»ÑÐ½Ð¾Ð¼ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ð¸ ÑÑÐ¸Ñ Ð¾Ð±Ð»Ð°ÑÑÐµÐ¹. Ð ÐµÐ·ÑÐ»ÑÑÐ°ÑÑ, Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÐµ Ð² ÑÐ¾Ð´Ðµ ÑÑÐ¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ, Ð¼Ð¾Ð³ÑÑ Ð±ÑÑÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ñ Ð´Ð»Ñ ÐºÐ¾ÑÑÐµÐºÑÐ¸Ð¸ ÑÑÐµÐ¼Ñ Ð»ÐµÑÐµÐ½Ð¸Ñ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ð¹, ÑÐ²ÑÐ·Ð°Ð½Ð½ÑÑ Ñ Ð´Ð¸Ð·ÑÐµÐ³ÑÐ»ÑÑÐ¸ÐµÐ¹ Ð´Ð¾ÑÐ°Ð¼Ð¸Ð½ÐµÑÐ³Ð¸ÑÐµÑÐºÐ¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ, ÑÐ°Ðº ÐºÐ°Ðº Ð¾Ð½Ð¸ Ð¿Ð¾ÐºÐ°Ð·ÑÐ²Ð°ÑÑ ÑÑÑÑÐºÑÑÑÑ Ð¦ÐÐ¡, Ð½Ð°Ð¸Ð±Ð¾Ð»ÐµÐµ Ð½ÑÐ¶Ð´Ð°ÑÑÐ¸ÐµÑÑ Ð² ÑÐµÑÐ°Ð¿Ð¸Ð¸.
description: Attention deficit/hyperactivity disorder (ADHD) is a complex neurogenic disorder that manifests itself in childhood. Earlier studies have shown a link between ADHD and the gene encoding the dopamine transporter DAT. Therefore, rats with a dopamine transporter knockout (DAT-KO) represent an optimal model for investigating ADHD. DAT-KO rats demonstrate hyperactivity, cognitive deficits, attention deficit, and impulsive behavior. The given work is devoted to the study of the dynamics of maturation of the nervous system in the offspring of rats of the DAT-KO line with their natural development. The study was conducted on rats with the genotypes DAT-KO, HET (heterozygote by knockout of the DAT gene), and WT (wild type). In the first week of life, increased locomotor activity was shown by the DAT-KO rats in the pivoting locomotion test. After the second week of life, tests evaluating sensory-motor reflexes showed no significant differences. It has been shown that DAT-KO and HET rat pups gain weight faster during the first two weeks of life. On day 30, there were no differences in either physical development or behavior (open field test). The content of biogenic monoamines in such structures as the striatum, prefrontal, entorhinal and motor cortexes, hippocampus, and cerebellum in the preadolescent period in DAT-KO and HET rats does not differ from WT, which may indicate the normal development of these areas. The results obtained in the course of this work can be used to correct the treatment regimen of diseases associated with dysregulation of the dopaminergic system, as they show the structures of the central nervous system that are most in need of therapy.