cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
USER-FRIENDLY TOOLS FOR QUANTIFYING THE DYNAMICS OF CELLULAR MORPHOLOGY AND INTRACELLULAR PROTEIN CLUSTERS
Creators: name: Elston, Timothy C.
name: Tsygankov, Denis
name: Hahn, Klaus M.
name: Chu, Pei-Hsuan
name: Chen, Hsin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Understanding the heterogeneous dynamics of cellular processes requires not only tools to visualize molecular behavior, but also versatile approaches to extract and analyze the information contained in live-cell movies of many cells. Automated identification and tracking of cellular features enables thorough and consistent comparative analyses in a high-throughput manner. Here we present tools for two challenging problems in computational image analysis: 1) classification of motion for cells with complex shapes and dynamics, and 2) segmentation of clustered cells and quantification of intracellular protein distributions based on a single fluorescence channel. We describe these methods, and user-friendly software* (MATLAB applications with Graphical User Interfaces) so these tools can be readily applied without an extensive knowledge of computational techniques.
Additional file 1 of Growth pattern in children with X-linked hypophosphatemia treated with burosumab and growth hormone
Creators: name: Ertl, Diana-Alexandra
name: Le Lorier, Justin
name: Gleiss, Andreas
name: Trabado, Séverine
name: Bensignor, Candace
name: Audrain, Christelle
name: Zhukouskaya, Volha
name: Coutant, Régis
name: Berkenou, Jugurtha
name: Rothenbuhler, Anya
name: Haeusler, Gabriele
name: Linglart, Agnès
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences
subject: Computational Biology

description: Additional file 1: Table S1. Demographic, clinical and biochemical characteristics for group 1 (burosumab only). Median, minimum and maximum for demographic and biochemical parameters.
Wireless Mobility Management with Prediction, Delay Reduction and Resource Management in 802.11 Networks
Creators: name: Issac, B.
name: Hamid, K.
name: Tan, C. E.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: In 802.11 wireless infrastructure networks, as the mobile node moves from one access point to another, the active connections will not be badly dropped if the handoff is smooth and if there are sufficient resources reserved in the target access point. In a 5x5 grid of access points, within a 6x6 grid of regions, by location tracking and data mining, we predict the mobility pattern of mobile node with good accuracy. The pre-scanning of mobile nodes, along with pre-authenticating neighbouring access points and pre-reassociation is used to reduce the scan delay, authentication delay and re-association delay respectively. The model implements first stage reservation by using prediction results and does second stage reservation based on the packet content type, so that sufficient resources can be reserved when the mobile node does the handoff to the next access point. The overall mobility management scheme thus reduces the handoff delay. The performance simulations are done to verify the proposed model.
description: 16 pages
Cultural Resource Survey of Five Acres for a Proposed Dumping Area, Kirtland Air Force Base
Creators: name: Poague, Wendy J.
Publisher: name: Mariah Associates, Inc.
Year: 1993
Subjects: subject: Bernalillo (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/3646/bernalillo-county
subject: Albuquerque, New Mexico
valueUri: https://core.tdar.org/browse/geographic-keyword/84765/albuquerque-new-mexico
subject: Kirtland Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/17943/kirtland-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/temporal-keyword/5728/historic
subject: Prehistoric
valueUri: https://core.tdar.org/browse/temporal-keyword/53/prehistoric
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Modern Trash
valueUri: https://core.tdar.org/browse/material-type/3362/modern-trash
subject: Negative Result
valueUri: https://core.tdar.org/browse/other-keyword/76495/negative-result
subject: Dump Area
valueUri: https://core.tdar.org/browse/other-keyword/42839/dump-area
subject: Pedestrian Survey
valueUri: https://core.tdar.org/browse/other-keyword/9852/pedestrian-survey
subject: Cultural Resources Clearance
valueUri: https://core.tdar.org/browse/other-keyword/168090/cultural-resources-clearance
subject: Reconnaissance / Survey
valueUri: https://core.tdar.org/browse/investigation-type/7/reconnaissance-survey

description: Mariah Associates, Inc. completed a Class III Cultural Resource Inventory for a proposed dumping area and access route related to Albuquerque International Airport construction, on Kirtland Air Force Base, Bernalillo County, New Mexico. The survey was requested by Wayne Frasier of Mountain States Constructors, Inc. The project encompassed a five acre area for the dump. Clean cement and other construction materials will be deposited by truck and will be covered over with clean fill. Survey took place on May 5, 1993 by Wendy Jones Poague and Grace Hawkins of Mariah Associates, Inc. No cultural resources were observed during the survey. As a result, cultural resource clearance for the proposed undertaking is recommended.
Archaeological Site Evaluation of an Historic Dump, LA 71432, in the Vicinity of Albuquerque, New Mexico
Creators: name: Cushman, David
Publisher: name: Mariah Associates, Inc.
Year: 1989
Subjects: subject: Bernalillo (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/3646/bernalillo-county
subject: Albuquerque, New Mexico
valueUri: https://core.tdar.org/browse/geographic-keyword/84765/albuquerque-new-mexico
subject: Kirtland Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/17943/kirtland-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/temporal-keyword/5728/historic
subject: Prehistoric
valueUri: https://core.tdar.org/browse/temporal-keyword/53/prehistoric
subject: World War II
valueUri: https://core.tdar.org/browse/temporal-keyword/3992/world-war-ii
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: LA 3842
valueUri: https://core.tdar.org/browse/site-name/130102/la-3842
subject: LA 3840
valueUri: https://core.tdar.org/browse/site-name/130104/la-3840
subject: LA 3841
valueUri: https://core.tdar.org/browse/site-name/130103/la-3841
subject: LA 71432
valueUri: https://core.tdar.org/browse/site-name/130105/la-71432
subject: Trash Midden
valueUri: https://core.tdar.org/browse/site-type/351/trash-midden
subject: Artifact Scatter
valueUri: https://core.tdar.org/browse/site-type/340/artifact-scatter
subject: Modern Dumpsite
valueUri: https://core.tdar.org/browse/site-type/4646/modern-dumpsite
subject: Textile
valueUri: https://core.tdar.org/browse/material-type/16/textile
subject: Chipped Stone
valueUri: https://core.tdar.org/browse/material-type/2/chipped-stone
subject: Building Materials
valueUri: https://core.tdar.org/browse/material-type/8/building-materials
subject: Metal
valueUri: https://core.tdar.org/browse/material-type/11/metal
subject: Powerline
valueUri: https://core.tdar.org/browse/other-keyword/115361/powerline
subject: Easement
valueUri: https://core.tdar.org/browse/other-keyword/7048/easement
subject: Radar Facility
valueUri: https://core.tdar.org/browse/other-keyword/168058/radar-facility
subject: Cultural Resources Clearance
valueUri: https://core.tdar.org/browse/other-keyword/168090/cultural-resources-clearance
subject: Site Evaluation / Testing
valueUri: https://core.tdar.org/browse/investigation-type/10/site-evaluation-testing

description: This report presents the results of a site evaluation of a large historic refuse deposit in support of an electrical project for a new radar facility. A 20th Century trash dump site was discovered, LA 71432. However, archaeological clearance for the proposed undertaking is recommended.
Cultural Resources Survey for a Proposed Fire Extinguisher Training Site, Area IV, Sandia National Laboratories, Kirtland Air Force Base, New Mexico
Creators: name: Hoagland, Steven R.
Publisher: name: Chambers Group, Inc.
Year: 1990
Subjects: subject: Bernalillo (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/3646/bernalillo-county
subject: Albuquerque, New Mexico
valueUri: https://core.tdar.org/browse/geographic-keyword/84765/albuquerque-new-mexico
subject: Kirtland Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/17943/kirtland-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/temporal-keyword/5728/historic
subject: Prehistoric
valueUri: https://core.tdar.org/browse/temporal-keyword/53/prehistoric
subject: LA 69739
valueUri: https://core.tdar.org/browse/site-name/129982/la-69739
subject: LA 38139
valueUri: https://core.tdar.org/browse/site-name/126605/la-38139
subject: LA 69738
valueUri: https://core.tdar.org/browse/site-name/129983/la-69738
subject: SNL Area IV
valueUri: https://core.tdar.org/browse/site-name/130516/snl-area-iv
subject: Building 980
valueUri: https://core.tdar.org/browse/site-name/119075/building-980
subject: Facility 980
valueUri: https://core.tdar.org/browse/site-name/130519/facility-980
subject: KAFB Management Area A
valueUri: https://core.tdar.org/browse/site-name/130520/kafb-management-area-a
subject: NM I:14:4:9
valueUri: https://core.tdar.org/browse/site-name/130517/nm-i1449
subject: Area IV
valueUri: https://core.tdar.org/browse/site-name/130518/area-iv
subject: Artifact Scatter
valueUri: https://core.tdar.org/browse/site-type/340/artifact-scatter
subject: Fire Extinguisher Training Site
valueUri: https://core.tdar.org/browse/site-type/4679/fire-extinguisher-training-site
subject: Rock Alignment
valueUri: https://core.tdar.org/browse/site-type/360/rock-alignment
subject: Negative Result
valueUri: https://core.tdar.org/browse/other-keyword/76495/negative-result
subject: Construction
valueUri: https://core.tdar.org/browse/other-keyword/78740/construction
subject: Cultural Resources Clearance
valueUri: https://core.tdar.org/browse/other-keyword/168090/cultural-resources-clearance
subject: Reconnaissance / Survey
valueUri: https://core.tdar.org/browse/investigation-type/7/reconnaissance-survey

description: An archaeological survey of approximately 0.44 acres of property scheduled for construction of a proposed fire extinguisher training site in Area IV, Sandia National Laboratories, Kirtland Air Force Base, Bernalillo County, New Mexico, yielded no cultural resources. The survey included a 0.23 acre area proposed for construction of the training site and a 0. 21 acre area located directly to the east. The additional area was inventoried, as at the time the fieldwork was conducted, it was unknown whether the training-site would have be moved out of an existing firing area which included the western portion of the proposed area. Since no significant cultural resources will be effected by the proposed undertaking, cultural resource clearance is recommended for construction of a 0.23 acre area for use as a fire extinguisher training site.
High-Throughput SHAPE and Hydroxyl Radical Analysis of RNA Structure and Ribonucleoprotein Assembly
Creators: name: McGinnis, Jennifer L.
name: Weeks, Kevin M.
name: Duncan, Caia D.S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: RNA folds to form complex structures vital to many cellular functions. Proteins facilitate RNA folding at both the secondary and tertiary structure levels. An absolute prerequisite for understanding RNA folding and ribonucleoprotein (RNP) assembly reactions is a complete understanding of the RNA structure at each stage of the folding or assembly process. Here we provide a guide for comprehensive and high-throughput analysis of RNA secondary and tertiary structure using SHAPE and hydroxyl radical footprinting. As an example of the strong and sometimes surprising conclusions that can emerge from high-throughput analysis of RNA folding and RNP assembly, we summarize the structure of the bI3 group I intron RNA in four distinct states. Dramatic structural rearrangements occur in both secondary and tertiary structure as the RNA folds from the free state to the active, six-component, RNP complex. As high-throughput and high-resolution approaches are applied broadly to large protein-RNA complexes, other proteins previously viewed as making simple contributions to RNA folding are also likely to be found to exert multifaceted, long-range, cooperative, and nonadditive effects on RNA folding. These protein-induced contributions add another level of control, and potential regulatory function, in RNP complexes.
Fluctuation analysis of activity biosensor images for the study of information flow in signaling pathways
Creators: name: Hahn, Klaus
name: Danuser, Gaudenz
name: Tytell, Jessica
name: Halidi, Nadia
name: Elliott, Hunter
name: Besson, Sebastien
name: Vilela, Marco
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Comprehensive understanding of cellular signal transduction requires accurate measurement of the information flow in molecular pathways. In the past, information flow has been inferred primarily from genetic or protein-protein interactions. Although useful for overall signaling, these approaches are limited in that they typically average over populations of cells. Single cell data of signaling states are emerging, but these data are usually snapshots of a particular time point or limited to averaging over a whole cell. However, many signaling pathways are activated only transiently in specific subcellular regions. Protein activity biosensors allow measurement of the spatiotemporal activation of signaling molecules in living cells. These data contain highly complex, dynamic information that can be parsed out in time and space and compared with other signaling events as well as changes in cell structure and morphology. We describe in this chapter the use of computational tools to correct, extract, and process information from timelapse images of biosensors. These computational tools allow one to explore the biosensor signals in a multiplexed approach in order to reconstruct the sequence of signaling events and consequently the topology of the underlying pathway. The extraction of this information, dynamics and topology, provides insight into how the inputs of a signaling network are translated into its biochemical or mechanical outputs.
Resonant atom-dimer collisions in cesium: Testing universality at positive scattering lengths
Creators: name: Zenesini, Alessandro
name: Huang, Bo
name: Berninger, Martin
name: Nägerl, Hanns-Christoph
name: Ferlaino, Francesca
name: Grimm, Rudolf
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We study the collisional properties of an ultracold mixture of cesium atoms and dimers close to a Feshbach resonance near 550G in the regime of positive $s$-wave scattering lengths. We observe an atom-dimer loss resonance that is related to Efimov's scenario of trimer states. The resonance is found at a value of the scattering length that is different from a previous observation at low magnetic fields. This indicates non-universal behavior of the Efimov spectrum for positive scattering lengths. We compare our observations with predictions from effective field theory and with a recent model based on the van der Waals interaction. We present additional measurements on pure atomic samples in order to check for the presence of a resonant loss feature related to an avalanche effect as suggested by observations in other atomic species. We could not confirm the presence of such a feature.
RNA SHAPE Analysis of Small RNAs and Riboswitches
Creators: name: Favorov, Oleg V.
name: Busan, Steven
name: Rice, Greggory M.
name: Weeks, Kevin M.
name: Karabiber, Fethullah
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: We describe structural analysis of RNAs by SHAPE chemical probing. RNAs are treated with 1-methyl-7-nitroisatoic anhydride (1M7), a reagent that detects local nucleotides flexibility, and N-methylisatoic anhydride (NMIA) and 1-methyl-6-nitroisatoic anhydride (1M6), reagents which together detect higher-order and non-canonical interactions. Chemical adducts are detected as stops during reverse transcriptase-mediated primer extension. Probing information can be used to infer conformational changes and ligand binding, and to develop highly accurate models of RNA secondary structures.
Additional file 1 of Companion animals and child development outcomes: longitudinal and cross-sectional analysis of a UK birth cohort study
Creators: name: Purewal, Rebecca
name: Christley, Robert
name: Kordas, Katarzyna
name: Joinson, Carol
name: Meints, Kerstin
name: Gee, Nancy
name: Westgarth, Carri
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1
Additional file 2 of Growth pattern in children with X-linked hypophosphatemia treated with burosumab and growth hormone
Creators: name: Ertl, Diana-Alexandra
name: Le Lorier, Justin
name: Gleiss, Andreas
name: Trabado, Séverine
name: Bensignor, Candace
name: Audrain, Christelle
name: Zhukouskaya, Volha
name: Coutant, Régis
name: Berkenou, Jugurtha
name: Rothenbuhler, Anya
name: Haeusler, Gabriele
name: Linglart, Agnès
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences
subject: Computational Biology

description: Additional file 2: Table S2 Demographic, clinical and biochemical characteristics for group 2 (burosumab and rhGH). Median, minimum and maximum for demographic and biochemical parameters
COEL: A Web-based Chemistry Simulation Framework
Creators: name: Banda, Peter
name: Blount, Drew
name: Teuscher, Christof
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computational Engineering, Finance, and Science (cs.CE)
subject: Chemical Physics (physics.chem-ph)
subject: Molecular Networks (q-bio.MN)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: The chemical reaction network (CRN) is a widely used formalism to describe macroscopic behavior of chemical systems. Available tools for CRN modelling and simulation require local access, installation, and often involve local file storage, which is susceptible to loss, lacks searchable structure, and does not support concurrency. Furthermore, simulations are often single-threaded, and user interfaces are non-trivial to use. Therefore there are significant hurdles to conducting efficient and collaborative chemical research. In this paper, we introduce a new enterprise chemistry simulation framework, COEL, which addresses these issues. COEL is the first web-based framework of its kind. A visually pleasing and intuitive user interface, simulations that run on a large computational grid, reliable database storage, and transactional services make COEL ideal for collaborative research and education. COEL's most prominent features include ODE-based simulations of chemical reaction networks and multicompartment reaction networks, with rich options for user interactions with those networks. COEL provides DNA-strand displacement transformations and visualization (and is to our knowledge the first CRN framework to do so), GA optimization of rate constants, expression validation, an application-wide plotting engine, and SBML/Octave/Matlab export. We also present an overview of the underlying software and technologies employed and describe the main architectural decisions driving our development. COEL is available at http://coel-sim.org for selected research teams only. We plan to provide a part of COEL's functionality to the general public in the near future.
description: 23 pages, 12 figures, 1 table
GRB 140206A: the most distant polarized Gamma-Ray Burst
Creators: name: Gotz, D.
name: Laurent, P.
name: Antier, S.
name: Covino, S.
name: D'Avanzo, P.
name: D'Elia, V.
name: Melandri, A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The nature of the prompt gamma-ray emission of Gamma-Ray Bursts (GRBs) is still far from being completely elucidated. The measure of linear polarization is a powerful tool that can be used to put further constraints on the content and magnetization of the GRB relativistic outflows, as well as on the radiation processes at work. To date only a handful of polarization measurements are available for the prompt emission of GRBs. Here we present the analysis of the prompt emission of GRB 140206A, obtained with INTEGRAL/IBIS, Swift/BAT, and Fermi/GBM. Using INTEGRAL/IBIS as a Compton polarimeter we were able to constrain the linear polarization level of the second peak of this GRB as being larger than 28% at 90% c.l. We also present the GRB afterglow optical spectroscopy obtained at the Telescopio Nazionale Galileo (TNG), which allowed us the measure the distance of this GRB, z=2.739. This distance value together with the polarization measure obtained with IBIS, allowed us to derive the deepest and most reliable limit to date (xi <1x10-16) on the possibility of Lorentz Invariance Violation, measured through the vacuum birefringence effect on a cosmological source.
description: 9 pages, 5 figures, 3 tables, accepted for publication in MNRAS. arXiv admin note: text overlap with arXiv:1303.4186
Comparative Genome Analysis of Ciprofloxacin-Resistant Pseudomonas aeruginosa Reveals Genes Within Newly Identified High Variability Regions Associated With Drug Resistance Development
Creators: name: Su, Hsun-Cheng
name: Kanavy, Dona M.
name: Khatun, Jainab
name: Giddings, Morgan C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The alarming rise of ciprofloxacin-resistant Pseudomonas aeruginosa has been reported in several clinical studies. Though the mutation of resistance genes and their role in drug resistance has been researched, the process by which the bacterium acquires high-level resistance is still not well understood. How does the genomic evolution of P. aeruginosa affect resistance development? Could the exposure of antibiotics to the bacteria enrich genomic variants that lead to the development of resistance, and if so, how are these variants distributed through the genome? To answer these questions, we performed 454 pyrosequencing and a whole genome analysis both before and after exposure to ciprofloxacin. The comparative sequence data revealed 93 unique resistance strain variation sites, which included a mutation in the DNA gyrase subunit A gene. We generated variation-distribution maps comparing the wild and resistant types, and isolated 19 candidates from three discrete resistance-associated high variability regions that had available transposon mutants, to perform a ciprofloxacin exposure assay. Of these region candidates with transposon disruptions, 79% (15/19) showed a reduction in the ability to gain high-level resistance, suggesting that genes within these high variability regions might enrich for certain functions associated with resistance development.
Department of Energy, Transportation Safeguard Academy Expansion, A Cultural Resources Survey: Sandia Ranger District, Cibola National Forest, Bernalillo County, New Mexico
Creators: name: Marsh, Neel
name: Wandsnider, LuAnn
Year: 1988
Subjects: subject: Bernalillo (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/3646/bernalillo-county
subject: Albuquerque, New Mexico
valueUri: https://core.tdar.org/browse/geographic-keyword/84765/albuquerque-new-mexico
subject: Kirtland Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/17943/kirtland-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/temporal-keyword/5728/historic
subject: Prehistoric
valueUri: https://core.tdar.org/browse/temporal-keyword/53/prehistoric
subject: Isolated Artifact
valueUri: https://core.tdar.org/browse/site-type/344/isolated-artifact
subject: Ceramic
valueUri: https://core.tdar.org/browse/material-type/1/ceramic
subject: Negative Result
valueUri: https://core.tdar.org/browse/other-keyword/76495/negative-result
subject: Transportation Safeguard Academy
valueUri: https://core.tdar.org/browse/other-keyword/168092/transportation-safeguard-academy
subject: Cultural Resources Clearance
valueUri: https://core.tdar.org/browse/other-keyword/168090/cultural-resources-clearance
subject: Reconnaissance / Survey
valueUri: https://core.tdar.org/browse/investigation-type/7/reconnaissance-survey

description: This report documents the performance and findings of a cultural resource survey for a project involving expansion of the Transportation Safeguard Academy located on withdrawn National Forest land. One isolated artifact was found. No other cultural remains were located. Cultural resources clearance is recommended.
Aquaserv_D5.1_TrainingGuidelinesandCourseTemplates_28Oct2024
Creators: name: Delgado, Claudia
Publisher: name: Zenodo
Year: 2024

description: This document describes the rationale and the approach for training delivery in AQUASERV, including some best practices. It also includes the course templates necessary to design pedagogically sound courses and the templates for online and/or blended delivery modes.
Analysis of corporate environmental reports using statistical techniques and data mining
Creators: name: Modapothala, J. R.
name: Issac, B.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Measuring the effectiveness of corporate environmental reports, it being highly qualitative and less regulated, is often considered as a daunting task. The task becomes more complex if comparisons are to be performed. This study is undertaken to overcome the physical verification problems by implementing data mining technique. It further explores on the effectiveness by performing exploratory analysis and structural equation model to bring out the significant linkages between the selected 10 variables. Samples of five hundred and thirty nine reports across various countries are used from an international directory to perform the statistical analysis like: One way ANOVA (Analysis of Variance), MDA (Multivariate Discriminant Analysis) and SEM (Structural Equation Modeling). The results indicate the significant differences among the various types of industries in their environmental reporting, and the exploratory factors like stakeholder, organization strategy and industrial oriented factors, proved significant. The major accomplishment is that the findings correlate with the conceptual frame work of GRI.
description: 8 pages
Cultural Resources Survey of 13.1 Acres Slated for Construction of the Deployable Seismic Verification System Site II for Sandia National Laboratories, Kirtland Air Force Base, New Mexico
Creators: name: Hoagland, Steven R.
Publisher: name: Chambers Group, Inc.
Year: 1989
Subjects: subject: Bernalillo (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/3646/bernalillo-county
subject: Albuquerque, New Mexico
valueUri: https://core.tdar.org/browse/geographic-keyword/84765/albuquerque-new-mexico
subject: Kirtland Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/17943/kirtland-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/temporal-keyword/5728/historic
subject: Prehistoric
valueUri: https://core.tdar.org/browse/temporal-keyword/53/prehistoric
subject: LA 47904
valueUri: https://core.tdar.org/browse/site-name/129950/la-47904
subject: KAFB Management Area I West
valueUri: https://core.tdar.org/browse/site-name/130560/kafb-management-area-i-west
subject: LA 47906
valueUri: https://core.tdar.org/browse/site-name/129951/la-47906
subject: NM 0:3:1:38
valueUri: https://core.tdar.org/browse/site-name/126648/nm-03138
subject: NM 0:2:2:5
valueUri: https://core.tdar.org/browse/site-name/126647/nm-0225
subject: LA 47905
valueUri: https://core.tdar.org/browse/site-name/129290/la-47905
subject: NM 0:3:1:37
valueUri: https://core.tdar.org/browse/site-name/126651/nm-03137
subject: Isolated Artifact
valueUri: https://core.tdar.org/browse/site-type/344/isolated-artifact
subject: Chipped Stone
valueUri: https://core.tdar.org/browse/material-type/2/chipped-stone
subject: Limestone
valueUri: https://core.tdar.org/browse/material-type/324/limestone
subject: Seismic Verification System Site II
valueUri: https://core.tdar.org/browse/other-keyword/168133/seismic-verification-system-site-ii
subject: Reconnaissance / Survey
valueUri: https://core.tdar.org/browse/investigation-type/7/reconnaissance-survey

description: An archaeological survey has recently been completed by Chambers Group, Inc. for 13.1 acres of land leased by Sandia National Laboratories from Kirtland Air Force Base, Bernalillo County, New Mexico. The survey was performed prior to construction on a 10.6 acre building site of a facility to serve as the Deployable Seismic Verification System Site II, and on a 2.5 acre alignment scheduled for construction as an access road. One isolated occurrence (IO) was located within the proposed facility construction site. Due to the assumed lack of subsurface deposits and to the recordation of the observed artifact, it is the opinion of the author that cultural resource clearance should be granted for construction of the Deployable Seismic Verification System Site II and for its associated access road.
beta-Lactamase can function as a reporter of bacterial protein export during Mycobacterium tuberculosis infection of host cells
Creators: name: McDonough, J. A.
name: McCann, J. R.
name: Pavelka, M. S.
name: Braunstein, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Mycobacterium tuberculosis is an intracellular pathogen that is able to avoid destruction by host immune defenses. Exported proteins of M. tuberculosis, which include proteins localized to the bacterial surface or secreted into the extracellular environment, are ideally situated to interact with host factors. As a result, these proteins are attractive candidates for virulence factors, drug targets, and vaccine components. Here we describe a new β-lactamase reporter system capable of identifying exported proteins of M. tuberculosis during growth in host cells. Because β-lactams target bacterial cell wall synthesis, β-lactamases must be exported beyond the cytoplasm to protect against these drugs. When used in protein fusions, β-lactamase can report on the subcellular location of another protein as measured by protection from β-lactam antibiotics. Here we demonstrate that a truncated TEM-1 β-lactamase lacking a signal sequence for export (‘BlaTEM-1) can be used in this manner directly in a mutant strain of M. tuberculosis lacking the major β-lactamase, BlaC. The ‘BlaTEM-1 reporter conferred β-lactam resistance when fused to both Sec and Tat export signal sequences. We further demonstrate that β-lactamase fusion proteins report on protein export while M. tuberculosis is growing in THP-1 macrophage-like cells. This genetic system should facilitate the study of proteins exclusively exported in the host environment by intracellular M. tuberculosis.
Effect of dopants on thermal stability and self-diffusion in iron nitride thin films
Creators: name: Tayal, Akhil
name: Gupta, Mukul
name: Gupta, Ajay
name: Horisberger, M.
name: Stahn, Jochen
name: Schlage, Kai
name: Wille, H. -C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We studied the effect of dopants (Al, Ti, Zr) on the thermal stability of iron nitride thin films prepared using a dc magnetron sputtering technique. Structure and magnetic characterization of deposited samples reveal that the thermal stability together with soft magnetic properties of iron nitride thin films get significantly improved with doping. To understand the observed results, detailed Fe and N self-diffusion measurements were performed. It was observed that N self-diffusion gets suppressed with Al doping whereas Ti or Zr doping results in somewhat faster N diffusion. On the other hand Fe self-diffusion seems to get suppressed with any dopant of which heat of nitride formation is significantly smaller than that of iron nitride. Importantly, it was observed that N self-diffusion plays only a trivial role, as compared to Fe self-diffusion, in affecting the thermal stability of iron nitride thin films. Based on the obtained results effect of dopants on self-diffusion process is discussed.
description: 10 pages, 9 figs
Additional file 1 of Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer
Creators: name: Shozu, Kanto
name: Kaneko, Syuzo
name: Shinkai, Norio
name: Dozen, Ai
name: Kosuge, Hirofumi
name: Nakakido, Makoto
name: Machino, Hidenori
name: Takasawa, Ken
name: Asada, Ken
name: Komatsu, Masaaki
name: Tsumoto, Kouhei
name: Ohnuma, Shin-Ichi
name: Hamamoto, Ryuji
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 1: It includes supplementary Figs. 1–8 and supplementary raw data 1–3
Identification of the Staphylococcus aureus MSCRAMM clumping factor B (ClfB) binding site in the  C-domain of human fibrinogen
Creators: name: Miajlovic, H.
name: Gorkun, O. V.
name: Foster, T. J.
name: Walsh, E. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Clumping factor B (ClfB) of Staphylococcus aureus binds to cytokeratin 10 and to fibrinogen. In this study the binding site in human fibrinogen was localized to a short region within the C terminus of the Aα-chain. ClfB only bound to the Aα-chain of fibrinogen in a ligand-affinity blot and in solid-phase assays with purified recombinant fibrinogen chains. A variant of fibrinogen with wild-type Bβ- and γ-chains but with a deletion that lacked the C-terminal residues from 252–610 of the Aα-chain did not support adherence of S. aureus Newman expressing ClfB. A series of truncated mutants of the recombinant Aα-chain were tested for their ability to support adherence of S. aureus Newman ClfB+, which allowed the binding site to be localized to a short segment of the unfolded flexible repeated sequence within the C terminus of the Aα-chain. This was confirmed by two amino acid substititions within repeat 5 of the recombinant Aα-chain which did not support adherence of Newman ClfB+. Lactococcus lactis expressing ClfB mutants with amino acid substitutions (N256 and Q235) located in the putative ligand-binding trench between domains N2 and N3 of the A-domain were defective in adherence to immobilized fibrinogen and cytokeratin 10, suggesting that both ligands bind to the same or overlapping regions.
Orlando, P., II tomismo a Napoli nel sec. XIX. La Scuola del Sanseverino. I. Fonti e documenti. Ed. delia Pont. Un. Lateran. Vol. de 294 ps. 170x240. Roma 1968
Creators: name: Arieiro, José
Publisher: name: Theologica
Year: 1969

description: Theologica, v. 4 n. 2-3 (1969)
Waveguides with asymptotically diverging twisting
Creators: name: Krejcirik, David
Publisher: name: arXiv
Year: 2014
Subjects: subject: Spectral Theory (math.SP)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We provide a class of unbounded three-dimensional domains of infinite volume for which the spectrum of the associated Dirichlet Laplacian is purely discrete. The construction is based on considering tubes with asymptotically diverging twisting angle.
description: 6 pages, 2 figures
Cultural Resources Clearance Survey Tank Arena 5/8 Inch Cable Site
Creators: name: Hayden, John S.
Year: 1985
Subjects: subject: Bernalillo (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/3646/bernalillo-county
subject: Albuquerque, New Mexico
valueUri: https://core.tdar.org/browse/geographic-keyword/84765/albuquerque-new-mexico
subject: Kirtland Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/17943/kirtland-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/temporal-keyword/5728/historic
subject: Prehistoric
valueUri: https://core.tdar.org/browse/temporal-keyword/53/prehistoric
subject: Negative Result
valueUri: https://core.tdar.org/browse/other-keyword/76495/negative-result
subject: Clearance
valueUri: https://core.tdar.org/browse/other-keyword/154162/clearance
subject: Reconnaissance / Survey
valueUri: https://core.tdar.org/browse/investigation-type/7/reconnaissance-survey

description: This report documents the performance and findings of a Cultural Resource Survey for a proposed widening of a circular test area.
Fisher information of Markovian decay modes - Nonequilibrium equivalence principle, dynamical phase transitions and coarse graining
Creators: name: Polettini, Matteo
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We introduce the Fisher information in the basis of decay modes of Markovian dynamics, arguing that it encodes important information about the behavior of nonequilibrium systems. In particular we generalize an orthonormality relation between decay eigenmodes of detailed balanced systems to normal generators that commute with their time-reversal. Viewing such modes as tangent vectors to the manifold of statistical distributions, we relate the result to the choice of a coordinate patch that makes the Fisher-Rao metric Euclidean at the steady distribution, realizing a sort of statistical equivalence principle. We then classify nonequilibrium systems according to their spectrum, showing that a degenerate Fisher matrix is the signature of the insurgence of a class of dynamical phase transitions between nonequilibrium regimes, characterized by level crossing and power-law decay in time of suitable order parameters. An important consequence is that normal systems cannot manifest critical behavior. Finally, we study the Fisher matrix of systems with time-scale separation.
description: 9 pages, 1 figure. Edited version of arXiv:1105.4134
USDA Forest Service Inventory Standards and Accounting Form: Department of Energy (DOE) Foxholes 11/92
Creators: name: Hayden, John S.
Year: 1992
Subjects: subject: Bernalillo (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/3646/bernalillo-county
subject: Albuquerque, New Mexico
valueUri: https://core.tdar.org/browse/geographic-keyword/84765/albuquerque-new-mexico
subject: Kirtland Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/17943/kirtland-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/temporal-keyword/5728/historic
subject: Prehistoric
valueUri: https://core.tdar.org/browse/temporal-keyword/53/prehistoric
subject: Negative Result
valueUri: https://core.tdar.org/browse/other-keyword/76495/negative-result
subject: Foxholes
valueUri: https://core.tdar.org/browse/other-keyword/163731/foxholes
subject: Cultural Resources Clearance
valueUri: https://core.tdar.org/browse/other-keyword/168090/cultural-resources-clearance
subject: Reconnaissance / Survey
valueUri: https://core.tdar.org/browse/investigation-type/7/reconnaissance-survey

description: A cultural resources survey was done on approximately 6.7 acres on the Sandia Ranger District of the Cibola National Forest on the Department of Energy (DOE) Withdrawal for a project involving digging fox holes for military maneuvers. The area was part of two previous surveys and nothing was found. This survey also found no cultural remains. No cultural resource will be effected.
Arbuscular Mycorrhizal Fungi-Assisted Phytoextraction of Toxic Metals by Zea mays L. From Tannery Sludge
Creators: name: Singh, Geetu
name: Pankaj, Umesh
name: Chand, Sukhmal
name: Verma, Rajesh Kumar
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: In present study, arbuscular mycorrhizal fungi (AMF) were used for growth promotion of Zea mays L. in heavy metal rich tannery sludge (HMRTS). In order to identify suitable AMF species, a pot experiment was conducted using Rhizophagus fasciculatus, Rhizophagus intraradices, Funneliformis mosseae and Glomus aggregatum for cultivation of Zea mays L. under HMRTS. The plant growth and phytoremediation potential were significantly influenced by AMF treatments. The shoot weight and root length of F. mosseae treated Z. mays plants were significantly increased by 113 and 49%, respectively as compared to control. Likewise, maximum level of proline accumulation, chlorophyll content of leaves and, phosphorous content of shoot and root were recorded 55, 43, 57, and 64%, respectively in F. mosseae treatment. Interestingly, F. mosseae act as a bio-filter in the roots and modulate direct translocation of heavy metals (Cd, Cr, Ni, Pb) and micronutrients from soil to shoot (Bioaccumulation factor) as well roots to shoots (Translocation factor) of plant. In HMRTS, AMF inoculation were also found to significantly improve the soil enzymes activity like dehydrogenase, β-Glucosidase, acid and alkaline phosphatase. The finding of this study suggests that AMF-assisted cultivation of Zea mays is a promising approach for the phytoremediation of HMRTS.
Oliveira, J. de, O. P., Testemunhas de Jeová e seus enganos. Ed. Pax. Vol. de 196 ps. 145x210. Braga 1969
Creators: name: Pinto, José Barbosa
Publisher: name: Theologica
Year: 1969

description: Theologica, v. 4 n. 2-3 (1969)
In vitro and in cell functional proteomics on natural compounds
Creators: name: Cassiano, Chiara
Publisher: name: Universita degli studi di Salerno
Year: 2014
Subjects: subject: CHIM/06 CHIMICA ORGANICA
subject: Chemical proteomics
subject: Mass spectrometry
subject: Natural compounds

description: 2012 - 2013
description: Chemical proteomics has acquired a pivotal role in chemical biology because of its peculiar capability to deeply analyze the proteome from many points of view. Proteins identification, characterization and quantification provide a detailed portrait of a biological system. In particular, pharmaceutical research is looking with interest at chemical proteomics because the mechanism of action of bioactive molecules remains one of the main challenge. Particularly, the identification of target proteins and investigation of ligand-receptor interactions are today considered essential steps in the drug discovery and development process. Affinity purification-based mass spectrometry approaches (AP-MS) have emerged as a valuable mean to link bioactive compounds to their cellular targets. In recent years, the application of such techniques led to successful results in determining the macromolecular partners of many interesting bioactive molecules. These techniques require the chemical modifications of the molecule of interest onto a solid matrix, in order to allow the bioactive compound to “fish out” its specific interactors from a cell lysate or a tissue extract. Once eluted, these cellular targets are identified by MS and bioinformatics analysis. Later on, the biological profile of the selected compound toward its cellular interactors is investigated by in vitro and/or in vivo assays.
Reversible acetylation regulates acetate and propionate metabolism in Mycobacterium smegmatis
Creators: name: Braunstein, M.
name: Hayden, J. D.
name: Chen, X.
name: Gunawardena, H. P.
name: Brown, L. R.
name: Perkowski, E. F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Carbon metabolic pathways are important to the pathogenesis of Mycobacterium tuberculosis, the causative agent of tuberculosis. However, extremely little is known about metabolic regulation in mycobacteria. There is growing evidence for lysine acetylation being a mechanism of regulating bacterial metabolism. Lysine acetylation is a post-translational modification in which an acetyl group is covalently attached to the side chain of a lysine residue. This modification is mediated by acetyltransferases, which add acetyl groups, and deacetylases, which remove the acetyl groups. Here we set out to test whether lysine acetylation and deacetylation impact acetate metabolism in the model mycobacteria Mycobacterium smegmatis, which possesses 25 candidate acetyltransferases and 3 putative lysine deacetylases. Using mutants lacking predicted acetyltransferases and deacetylases we showed that acetate metabolism in M. smegmatis is regulated by reversible acetylation of acetyl-CoA synthetase (Ms-Acs) through the action of a single pair of enzymes: the acetyltransferase Ms-PatA and the sirtuin deacetylase Ms-SrtN. We also confirmed that the role of Ms-PatA in regulating Ms-Acs regulation depends on cAMP binding. We additionally demonstrated a role for Ms-Acs, Ms-PatA and Ms-SrtN in regulating the metabolism of propionate in M. smegmatis. Finally, along with Ms-Acs, we identified a candidate propionyl-CoA synthetase, Ms5404, as acetylated in whole-cell lysates. This work lays the foundation for studying the regulatory circuit of acetylation and deacetylation in the cellular context of mycobacteria.
Interpreting high [O III]/Hbeta ratios with maturing starbursts
Creators: name: Stanway, E. R.
name: Eldridge, J. J.
name: Greis, S. M. L.
name: Davies, L. J. M.
name: Wilkins, S. M.
name: Bremer, M. N.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Star forming galaxies at high redshift show ubiquitously high ionization parameters, as measured by the ratio of optical emission lines. We demonstrate that local (z < 0.2) sources selected as Lyman break analogues also manifest high line ratios with a typical [O III]/H beta = 3.36(+0.14,-0.04) - comparable to all but the highest ratios seen in star forming galaxies at z ~ 2-4. We argue that the stellar population synthesis code BPASS can explain the high ionization parameters required through the ageing of rapidly formed star populations, without invoking any AGN contribution. Binary stellar evolution pathways prolong the age interval over which a starburst is likely to show elevated line ratios, relative to those predicted by single stellar evolution codes. As a result, model galaxies at near-Solar metallicities and with ages of up to ~100 Myr after a starburst typically have a line ratio [O III]/H beta~3, consistent with those seen in Lyman break galaxies and local sources with similar star formation densities. This emphasises the importance of including binary evolution pathways when simulating the nebular line emission of young or bursty stellar populations.
description: 8 pages. MNRAS accepted