cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Regulation of basal cell plasticity : implications for airway epithelial remodeling in asthma
Creators: name: Warner, Stephanie Mary Beth
Publisher: name: University of British Columbia
Year: 2014

description: Asthma is characterized by reversible airflow limitation, airway inflammation and remodeling, which includes increased smooth muscle mass, sub-epithelial fibrosis, goblet cell metaplasia and loss of columnar epithelial cells. Basal cells are progenitor cells of the pseudostratified airway epithelium that undergo distinct phenotypic transitions to maintain epithelial homeostasis following damage. We hypothesized that differentiation of epithelial basal cells is defective in asthma, leading to impaired repair. We used three distinct in vitro models of human airway epithelial basal cell plasticity – epithelial-mesenchymal transition (EMT), repair of mechanical scratch wounds, and differentiation at air-liquid interface – which together provide a complete overview of basal cell function in epithelial repair. In Chapter 3 we assessed the ability of transforming growth factor (TGF)-β₁ to induce molecular reprogramming indicative of EMT and found that basal cells from asthmatic and non-asthmatic patients undergo TGFβ₁-induced EMT. However, an expanded population of basal cells in differentiated epithelial cultures from asthmatic donors led to an increased EMT response. In Chapter 4 we found that inhibition of ΔNp63α impaired restitution of scratch wounds in monolayer culture, due to decreased proliferation. Additionally, ΔNp63α regulated several genes known to be involved in epithelial repair, including β-catenin, epidermal growth factor receptor, and jagged1. In Chapter 5 we found that basal epithelial cells from asthmatic donors with (+) and without (-) exercise-induced bronchoconstriction (EIB) were impaired in the transition to a ciliated but not goblet cell phenotype in an air-liquid interface (ALI) model of mucociliary differentiation. EIB(-) asthmatics also had an expansion of the basal cell population and shorter cilia. In Chapter 6, we used an unbiased RNA sequencing approach to identify aberrant expression of pathways involved in actin cytoskeleton dynamics and cellular metabolism that were distinctly different in EIB(-) and EIB(+) asthma during mucociliary differentiation. We also identified a miRNA-mRNA network that regulates the epithelial transition from proliferation to differentiation. This thesis provides compelling evidence that lineage commitment and molecular reprogramming in basal cells are skewed in asthma to favour epithelial plasticity in response to TGFβ₁, rather than mucociliary differentiation, and that epithelial remodeling is more pronounced in the EIB(-) phenotype of asthma.
Additional file 1 of Incidence of stroke in patients with atrial fibrillation undergoing surgical treatment: a meta-analysis
Creators: name: Lin, Deqing
name: Cheng, Yongbo
name: Yu, Sanjiu
name: Liu, Xin
name: Yan, Chaojun
name: Cheng, Wei
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Science Policy

description: Supplementary Material 1
Role of high-spin hyperon resonances in the reaction of $γp \to K^+ K^+ Ξ^-$
Creators: name: Man, J. Ka Shing
name: Oh, Yongseok
name: Nakayama, K.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The recent data taken by the CLAS Collaboration at the Thomas Jefferson National Accelerator Facility for the reaction of $γp \to K^+ K^+ Ξ^-$ are reanalyzed within a relativistic meson-exchange model of hadronic interactions. The present model is an extension of the one developed in an earlier work by Nakayama, Oh, and Haberzettl [Phys. Rev. C 74, 035205 (2006)]. In particular, the role of the spin-5/2 and -7/2 hyperon resonances, which were not included in the previous model, is investigated in the present study. It is shown that the contribution of the $Σ(2030)$ hyperon having spin-7/2 and positive parity has a key role to bring the model predictions into a fair agreement with the measured data for the $K^+Ξ^-$ invariant mass distribution.
description: 8 pages, 3 figures, REVTeX
The Environmental Resource Management Paradox in an Impoverished Urban Population: A Case Study from Malaysia
Creators: name: Murad, Md. Wahid
name: Alam, Md. Mahmudul
Publisher: name: figshare
Year: 2022
Subjects: Economics

description: The extent and scope of understanding the nexus between poverty and environment are so extensive as well as complex that existing studies do not provide a concrete answer to the paradox. In the same vein, this study aims to contribute further to extent literature by assessing the attitude and behavior of the urban impoverished population concerning their management of solid wastes at household level. It also determines the factors that could potentially affect their willingness to pay for an improved access to solid waste collection and disposal services in their residential areas. The empirical findings obtained through some statistical and econometric analyses do not actually support the widely voiced assertion that the poor populations degrade the environment. But the findings strongly support the fact that urban impoverished populations do not actually degrade but they protect the environment by undertaking some environment-friendly waste management practices and contributing monetarily for an improvement in the environmental quality.
Additional file 1 of Effect of maternal separation and transportation stress on the bovine upper respiratory tract microbiome and the immune response to resident opportunistic pathogens
Creators: name: Malmuthuge, Nilusha
name: Howell, Angela
name: Arsic, Natasa
name: Prysliak, Tracy
name: Perez-Casal, Jose
name: Griebel, Philip
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology
subject: Computational Biology

description: Additional file 1. Microbial profiles, taxonomic composition and functional profiles of URT microbiome.
Presenting Women as Sexual Objects in Marketing Communications: Perspective of Morality, Ethics and Religion
Creators: name: Alam, Md. Mahmudul
name: Aliyu, Ahmed
name: Shahriar, Shawon Muhammad
Publisher: name: figshare
Year: 2022
Subjects: subject: 150502 Marketing Communications
subject: FOS: Economics and business

description: Purpose: In the current information age, when the attention spans of most people have become very short, marketers are facings serious challenges to grab the attention of their target audience effectively and fruitfully. From street corner to bedroom, virtually every perceivable location of human traces are littered with activity of marketers, whether they are small or large in scale, or the recipients of their information understand the message properly or not. Studying consumers’ acceptance of the main ethical issues in communication, mainly in advertising has recently been receiving much attention from scholars. Therefore, in order to grab the attention of people in the increasing competitive environment, advertisers have resorted to using what they feel can quickly attract the audience. For example, the attachment of attractive women with their physical natural endowments presented in explicit sexually appealing postures to products/services that have no linkage with women. These practices have raised some moral and ethical questions within the society. Therefore, the scope of this study focuses on discussing marketing communication through presenting women as a sexual object from the morality, ethics, and religious perspectives.Design/methodology/approach: This is a descriptive study based on the systematic literature review. Initially, this paper discusses the ethical issues of using women and sexual appeals in the process of marketing communication as well as the current level of practices in the industry. Then, it discusses the consequences and dimensions of the issues from different types of ethical grounds. Finally, it provides recommendations with the objective of finding a common ground from business and social perspectives. It also mentions the scopes of further research, which could lead the secular world to modify their moral values and come closer to the norms of other civilized societies.Findings: The position of the paper takes is that considering the negative effects of the prevalent advertising in society, the practice falls short of human moral values; as a result, it is considered unethical.Originality/value: This review paper examines the ethical implication of using women as marketing tools from the perspectives of morality, business, and Islamic principles that will help business groups as well as the whole religious community, especially Muslims.
Spectroscopy of dipolar fermions in 2D pancakes and 3D lattices
Creators: name: Hazzard, Kaden R. A.
name: Gorshkov, Alexey V.
name: Rey, Ana Maria
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Other Condensed Matter (cond-mat.other)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Motivated by ongoing measurements at JILA, we calculate the recoil-free spectra of dipolar interacting fermions, for example ultracold heteronuclear molecules, in a one-dimensional lattice of two-dimensional pancakes, spectroscopically probing transitions between different internal (e.g., rotational) states. We additionally incorporate p-wave interactions and losses, which are important for reactive molecules such as KRb. Moreover, we consider other sources of spectral broadening: interaction-induced quasiparticle lifetimes and the different polarizabilities of the different rotational states used for the spectroscopy. Although our main focus is molecules, some of the calculations are also useful for optical lattice atomic clocks. For example, understanding the p-wave shifts between identical fermions and small dipolar interactions coming from the excited clock state are necessary to reach future precision goals. Finally, we consider the spectra in a deep 3D lattice and show how they give a great deal of information about static correlation functions, including \textit{all} the moments of the density correlations between nearby sites. The range of correlations measurable depends on spectroscopic resolution and the dipole moment.
description: 14 pages, 6 figures
Phantom dosimetry of i-CAT CBCT and i-CAT panoramic radiographs in pediatric patients
Creators: name: Choi, Ella
Publisher: name: University of British Columbia
Year: 2014

description: Objectives: To obtain head dimensions from patients who received dental CBCT at BC Children’s Hospital (BCCH), to apply this information to design and construct small child and adolescent head phantoms, and to measure and compare the absorbed radiation doses from CBCT and panoramic radiographs using small child, adolescent and adult head phantoms. Materials and Methods: Patients who received dental CBCT at BCCH were surveyed. Head dimensions from each subject’s image were measured to develop adolescent and small child head phantoms. The most commonly used dental CBCT imaging protocols were examined. Absorbed doses were measured for small child, adolescent and adult head phantoms with i-CAT CBCT and Planmeca panoramic radiograph machines. Results: In the patient survey, 32 patients met the inclusion criteria. The most common indications for CBCT referral were for orthodontic treatment, followed by craniofacial abnormality and cleft lip and palate. A small child phantom was developed to represent the child patients with craniofacial abnormality and an adolescent phantom was developed to represent healthy orthodontic patients. Absorbed radiation doses varied depending on machine, imaging protocol, size of phantom and location of the ion chamber in the phantoms. For CBCT images, the highest radiation was measured in the small child phantom while the lowest radiation was measured in the adult phantom. For panoramic radiographs, the i-CAT CBCT panoramic option was compared to the Planmeca panoramic radiograph machine. For both machines, the small child phantom measured the highest while the adult phantom measured the lowest radiation. For the adolescent phantom, lower values were measured with the Planmeca machine while lower values were measured with i-CAT CBCT panoramic option for the small child phantom. Conclusion: Two groups of pediatric patients were referred for dental CBCT at BCCH: young patients with craniofacial abnormality and healthy adolescent patients for orthodontic assessment. A consistent trend was observed for both CBCT and panoramic radiographs: the highest dose was measured in the smallest phantom while the lowest dose was measured in the largest phantom. Radiation in pediatric population is more detrimental than in adult population and it is important to child size the dose and protocol.
Role of Integrity System, Internal Control System, and Leadership Practices on the Accountability Practices in the Public Sectors of Malaysia
Creators: name: Alam, Md. Mahmudul
name: Said, Jamaliah
name: Aziz, Mohamad Azizal bin Abd
Publisher: name: figshare
Year: 2022
Subjects: Economics

description: Purpose - This study assesses the status of current practices of accountability and its relationship with the practices of integrity system, internal control system, and leadership qualities in the public sector of Malaysia.Design/methodology/approach – This study collected primary data from 109 departments and agencies under 24 federal ministries in Malaysia. The data were analysed under descriptive statistics, ordinal regression, and structural equation modelling (SEM). Several diagnostic tests were conducted to check the validity and reliability of data and models, such as Cronbach alpha test, Kaiser-Meyer Olkin test, Shapiro Wilk test, Internal Consistency Reliability, Indicator Reliability, Convergent Validity, and Discriminant Validity, etc.Findings - The regression and SEM results show that the practices of integrity system and leadership quality had statistically significant positive relationship, but the practice of internal control system showed mixed relationship with the practices of accountability.Practical implications - The findings of the study will help the policy makers to ensure better accountability in the public sector in Malaysia and other countries.Originality/value – This is an original study based on primary data to examine the current practices of accountability and its relationship with the practices of integrity system, internal control system, and leadership qualities in the public sector of Malaysia.
Programming of stress regulation in 5 - 7 year old children by maternal gestational mood and antidepressant use
Creators: name: Hookenson, Kaia Vivian
Publisher: name: University of British Columbia
Year: 2014

description: Of particular importance to mental health across the life span is our capacity to regulate neuroendocrine responses to stressful events via the hypothalamic pituitary adrenal (HPA) axis. Prenatal exposure to maternal depression/anxiety may be among the earliest adverse experiences shown to influence the developing HPA system, possibly via changes in fetal serotonergic signaling. In addition, the developmental impact of prenatal exposure to serotonin reuptake inhibitor (SRI) antidepressants is often undistinguishable from prenatal maternal mood. The molecular mechanisms underlying how serotonin (5-HT) influences the development of the HPA stress system remain unclear, but may involve epigenetic mechanisms such as DNA methylation. This thesis explored whether prenatal exposure to SRIs and maternal depressed/anxious mood are associated with altered HPA stress reactivity, characterized by variable basal and stress-induced cortisol concentrations in 5 - 7 year-old children. Furthermore, the methylation status in promoter regions of NR3C1 1F (encodes the glucocorticoid receptor) and SLC6A4 (encodes the serotonin transporter) at birth and at 5 - 7 years of age was evaluated and the relationship to children’s cortisol patterns was assessed. Prenatal exposure to SRIs and higher 3rd trimester maternal depressed/anxious mood were associated with reduced cortisol stress responses at 5 - 7 years. Higher NR3C1 1F methylation at 5 - 7 years was associated with higher diurnal cortisol concentrations and a reduced cortisol stress response. Children exposed to mothers with higher 3rd trimester and concurrent anxious mood exhibited lower SLC6A4 methylation, compared to children exposed to higher 3rd trimester maternal anxious mood alone. Furthermore, children with higher SLC6A4 methylation at birth exhibited a reduced cortisol stress response. These findings suggest that the relationship between early life experiences and altered stress responses in early childhood may be moderated by epigenetic mechanisms involving the serotonergic and HPA regulatory systems. In addition, an interactive relationship between pre- and postnatal maternal mood with cortisol stress responses and methylation status at 5 - 7 years suggests that an early adverse environment may confer sensitivity toward altered HPA activity and regulation, and that the postnatal environment may shift the HPA stress response towards vulnerability or resilience to stress-related disorders across the lifespan.
Design of 2-amino-6-methyl-pyrimidine benzoic acids as ATP competitive casein kinase-2 (CK2) inhibitors using structure- and fragment-based design, docking and molecular dynamic simulation studies
Creators: name: Patel, S.
name: Tulsian, K.
name: Kumar, P.
name: Vyas, V.K.
name: Ghate, M.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Overexpression of casein kinase-2 (CK2) has been implicated in several carcinomas, mainly lung, prostate and acute myeloid leukaemia. The smaller nucleotide pocket compared to related kinases provides a great opportunity to discover newer ATP-competitive CK2 inhibitors. In this study, we have employed an integrated structure- and fragment-based design strategy to design 2-amino-6-methyl-pyrimidine benzoic acids as ATP-competitive CK2 inhibitors. A statistically significant four features-based E-pharmacophore (ARRR) model was used to screen 780,092 molecules. Further, the retrieved hits were considered for molecular docking study to identify essential binding interactions. At the same time, fragment-based virtual screening was performed using a dataset of 1,542,397 fragments. The identified hits and fragments were used as structure templates to rationalize the design of 2-amino-6-methyl-pyrimidine benzoic acids as newer CK2 inhibitors. Finally, the binding interactions of the designed hits were identified using an induced fit docking (IFD) study, and their stability was estimated by a molecular dynamics (MD) simulation study of 100 ns.
Search for H alpha emitters in Galaxy Clusters with Tunable Filters
Creators: name: Perez-Martinez, Ricardo
name: Sanchez-Portal, Miguel
name: Cepa, Jordi
name: Bongiovanni, Angel
name: Garcia, Ana Perez
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The studies of the evolution of galaxies in Galaxy Clusters have as a traditional complication the difficulty in establishing cluster membership of those sources detected in the field of view. The determination of spectroscopic redshifts involves long exposure times when it is needed to reach the cluster peripherical regions of/or clusters at moderately large redshifts, while photometric redshifts often present uncertainties too large to offer significant conclusions. The mapping of the cluster of galaxies with narrow band tunable filters makes it possible to reach large redshifts intervals with an accuracy high enough to establish the source membership of those presenting emission/absorption lines easily identifiable, as H alpha. Moreover, the wavelength scan can include other lines as [NII], [OIII] or $H_β$ allowing to distinguish those sources with strong stellar formation activity and those with an active galactic nuclei. All this makes it possible to estimate the stellar formation rate of the galaxies observed. This, together with ancillary data in other wavelengths may lead to a good estimation of the stellar formation histories. It will shed new light over the galaxy evolution in clusters and will improve our understanding of galaxy evolution, especially in the outer cluster regions, usually less studied and with significant unexploited data that can not be correctly interpreted without redshift determination.
description: 4 pages, 2 figures. "Highlights of Spanish Astrophysics V", Proceedings of the VIII Scientific Meeting of the Spanish Astronomical Society (SEA) held in Santander, 7-11 July, 2008
The Performance of Islamic Banks during the 2008 Global Financial Crisis: Evidence from the Gulf Cooperation Council Countries
Creators: name: Hussien, Mohammed Ebrahim
name: Alam, Md. Mahmudul
name: Murad, Md. Wahid
name: Wahid, Abu N. M.
Publisher: name: figshare
Year: 2022
Subjects: Economics

description: Purpose – The purpose of this study is to analyze the profitability performance of Islamic banks of the Gulf Cooperation Council (GCC) region during 2008 global financial crisis.Design/methodology/approach – Bank specific data are taken from the Bank Scope database and macroeconomic data are collected from International Financial Statistics. Using a panel data series of 30 banks for the period of 2005 to 2011, the study shows the evidence of structural break for the crisis year as well as the factors that impact the profitability of Islamic banks.Findings – The performance of GCC Islamic banks was significantly influenced during the crisis period by capital adequacy, credit risk, financial risk, operational efficiency, liquidity, bank size, gross domestic product, growth rate of money supply, bank sector development and inflation rate. The study also finds that there is a structural change before and after the global financial crisis.Originality/value – This is an original study that shows that the shariah compliant banks have performed better during the crisis and are not affected based on their internal performance records; rather, they have been affected indirectly from the macro shock due to the overall economic crisis.
Additional file 1 of Co-expression of auxiliary genes enhances the activity of a heterologous O2-tolerant hydrogenase in the cyanobacterium Synechocystis sp. PCC 6803
Creators: name: Lupacchini, Sara
name: Stauder, Ron
name: Opel, Franz
name: Klähn, Stephan
name: Schmid, Andreas
name: Bühler, Bruno
name: Toepel, Jörg
Publisher: name: figshare
Year: 2025
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Computational Biology

description: Supplementary Material 1: Fig. S1. Overview of the cloning strategy. Fig. S2. PCR to confirm the correct generation of Syn_PnrsBReSHp strain. Fig. S3. SDS-PAGE loading control for Western blot analysis of expression levels with different inducer concentrations. Fig. S4. SDS-PAGE as loading control for Western Blot analysis of expression levels at different time points after induction. Fig. S5. Soluble cell-free extract from Syn_∆hox used as negative control. Fig. S6. (RT)-PCR targeting hypX. Fig. S7. Growth curves of not induced and induced strains expressing C. necator hydrogenase and maturases. Fig. S8. Characterization of Syn_PnsrBCnSHg containing pPnrsBCnHypX or pPrhaBADCnHypX. Table S1. Protocol for plasmid generation and propagation in E. coli DH5α. Table S2. Sequences of primers used in this study and of basal genetic elements implemented in our MoClo system. Table S3. List of plasmids generated in this work. Table S4. Strains used in this study. Table S5. Gas concentrations during in vivo H2 consumption assay. Table S6. H2 uptake rate during H2 consumption assay.
Fusion Hindrance in the Heavy Ion Reactions -- Border Between the Normal and Hindered Fusions
Creators: name: Shen, Caiwan
name: Boilley, David
name: Li, Qingfeng
name: Shen, Junjie
name: Abe, Yasuhisa
Publisher: name: arXiv
Year: 2011
Subjects: subject: Nuclear Theory (nucl-th)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The fusion hindrance in heavy ion collisions is studied in the framework of the two-center liquid drop model. It appears that the neck and the radial degrees of freedom might both be hampered by an inner potential barrier on their path between the contact configuration to the compound nucleus. Heavy ion reactions with and without the two kinds of fusion hindrance are classified through systematic calculations. It is found that the number of reactions without radial fusion hindrance is much smaller than that without neck fusion hindrance, and for both kinds of fusion hindrance the number of reactions without fusion hindrance at small mass-asymmetry parameter $α$ is smaller than that at large $α$. In the formation of a given compound nucleus, if a reaction with $α_c$ is not hindered, then other reactions with $α> α_c$ are also not hindered as it is well known experimentally.
description: 14 pages, 7 figures
The Impacts of Climate Change on Road Traffic Accidents in Saudi Arabia
Creators: name: Islam, Md. Mazharul
name: Alharthi, Majed
name: Alam, Md. Mahmudul
Publisher: name: figshare
Year: 2022
Subjects: Economics

description: The potential costs of road traffic accidents (RTAs) to society are immense. Yet, no study has attempted to examine the impact of climate change on RTAs in Saudi Arabia, though RTA-leading deaths are very high, and the occurrence of climatic events is very frequent. Therefore, this study aims to assess the impact of climate change on RTAs in Saudi Arabia and to recommend some climate change mitigation and adaptation policies to make roads safe for all. This study employed annual data from 13 regions of Saudi Arabia, from 2003 to 2013. The data were analyzed on the basis of panel regression models—fixed effect, random effect, and the pooled ordinary least square. The findings show that temperature, rainfall, sandstorms, and number of vehicles were statistically and significantly responsible for RTAs in Saudi Arabia in the study period. This study also found that RTAs both inside and outside cities significantly caused injuries, but only RTAs inside cities significantly caused death. Furthermore, the death from RTAs injuries was found to be statistically significant only for motor vehicle accidents. The findings will assist policymakers in taking the right courses of action to mitigate the negative impacts of climate change through understanding climate influence on RTAs.
Sustainable rosin acid ester as internal electron donors in Ziegler-Natta catalysts for synthesis of isotactic polypropylene with high melt flow rate
Creators: name: Zhang, Jiaojiao
name: Yu, Hongchao
name: Xia, Xiaoqi
name: Zhang, Shaomeng
name: Huang, Qigu
name: Li, Chunman
name: Miao, Qing
name: Zhu, Feng
name: Yi, Jianjun
name: Zhao, Zhong
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: In this contribution, novel bio-derived rosin acid ester compounds have been developed and used as internal electron donors to prepare MgCl2 supported titanium catalysts for propylene polymerization. The results of the polymerization showed that tri-n-amyl maleate, triiso-amyl maleate and tri-n-heptyl maleate as internal electron donors in Ziegler-Natta catalysts all have high polymerization activity and stereoregularity. In particular, the Ziegler-Natta catalyst with tri-n-amyl maleate as the internal electron donor has the highest activity (up to 33.4 kgPP·gCat−1·h−1) for propylene polymerization and the isotacticity of polypropylene is as high as 96.8% determined by 13C NMR. Simultaneously, the obtained polypropylene with a relatively broad molecular weight distribution of 9.0 and melt flow rate of 160.3 g/10 min, which is beneficial to processing and has practical industrial application value when used as the basic material of melt blown cloth for medical mask.
A QSAR study to predict the survival motor neuron promoter activity of candidate diaminoquinazoline derivatives for the potential treatment of spinal muscular atrophy
Creators: name: Gürses, G. Sabuncu
name: Erdem, S.S.
name: Saçan, M.T.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified

description: Spinal Muscular Atrophy is a genetic neuromuscular disease that leads to muscle weakness and atrophy and it is characterized by the loss of α-motor neurons in the spinal cord’s anterior horn cells. The disease appears due to low levels of the survival motor neuron protein. There are continuing clinical trials for the treatment of Spinal Muscular Atrophy. Quinazoline–based compounds are promising since they were tested on fibroblasts derived from the patients and found to increase the survival motor neuron protein levels. In this study, using multiple linear regression, we generated robust and valid quantitative structure- activity relationship models to predict the survival motor neuron–2 promoter activity of the new candidate compounds using the experimental survival motor neuron–2 promoter activity values of 2,4–diaminoquinazoline derivatives taken from the literature. The novel compounds designed by combining the pyrido[1,2–α]pyrimidin–4–one moeity of the known drug Risdiplam with that of 2,4 – diaminoquinazoline scaffold were predicted to exhibit strong promoter activities.
The Inert Doublet Model and its Phenomenology
Creators: name: Gustafsson, Michael
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The single Higgs doublet in the standard model (SM) may be the simplest way of introducing electroweak symmetry breaking, but SM extensions with more scalar doublets are not excluded. A special case of the two Higgs doublet models is the inert doublet model - a minimalistic version with interesting phenomenology. These proceedings reviews the inert doublet model's theoretical setup, constraints, collider prospects and its dark matter phenomenology.
description: Conference proceedings from Third International Workshop on Prospects for Charged Higgs Discovery at Colliders - CHARGED2010, September 27-30, 2010, Uppsala Sweden. Minor updates to published version. 10 pages, 1 figure
Additional file 6 of DNA 5-hydroxymethylcytosine in pediatric central nervous system tumors may impact tumor classification and is a positive prognostic marker
Creators: name: Azizgolshani, Nasim
name: Petersen, Curtis L.
name: Chen, Youdinghuan
name: Levy, Joshua J.
name: Salas, Lucas A.
name: Perreard, Laurent
name: Nguyen, Lananh N.
name: Christensen, Brock C.
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 6. Supplemental Figures and Tables.
Ground-state ammonia and water in absorption towards Sgr B2
Creators: name: Wirström, E. S.
name: Bergman, P.
name: Black, J. H.
name: Hjalmarson, Å.
name: Larsson, B.
name: Olofsson, A. O. H.
name: Encrenaz, P. J.
name: Falgarone, E.
name: Frisk, U.
name: Olberg, M.
name: Sandqvist, Aa.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We have used the Odin submillimetre-wave satellite telescope to observe the ground state transitions of ortho-ammonia and ortho-water, including their 15N, 18O, and 17O isotopologues, towards Sgr B2. The extensive simultaneous velocity coverage of the observations, >500 km/s, ensures that we can probe the conditions of both the warm, dense gas of the molecular cloud Sgr B2 near the Galactic centre, and the more diffuse gas in the Galactic disk clouds along the line-of-sight. We present ground-state NH3 absorption in seven distinct velocity features along the line-of-sight towards Sgr B2. We find a nearly linear correlation between the column densities of NH3 and CS, and a square-root relation to N2H+. The ammonia abundance in these diffuse Galactic disk clouds is estimated to be about (0.5-1)e-8, similar to that observed for diffuse clouds in the outer Galaxy. On the basis of the detection of H218O absorption in the 3 kpc arm, and the absence of such a feature in the H217O spectrum, we conclude that the water abundance is around 1e-7, compared to ~1e-8 for NH3. The Sgr B2 molecular cloud itself is seen in absorption in NH3, 15NH3, H2O, H218O, and H217O, with emission superimposed on the absorption in the main isotopologues. The non-LTE excitation of NH3 in the environment of Sgr B2 can be explained without invoking an unusually hot (500 K) molecular layer. A hot layer is similarly not required to explain the line profiles of the 1_{1,0}-1_{0,1} transition from H2O and its isotopologues. The relatively weak 15NH3 absorption in the Sgr B2 molecular cloud indicates a high [14N/15N] isotopic ratio >600. The abundance ratio of H218O and H217O is found to be relatively low, 2.5--3. These results together indicate that the dominant nucleosynthesis process in the Galactic centre is CNO hydrogen burning.
description: 10 pages, 5 figures
Additional file 1 of Collaboration on evidence synthesis in Africa: a network study of growing research capacity
Creators: name: Pan, Jiayi
name: Zhong, Yongqi
name: Young, Sarah
name: Niezink, Nynke M. D.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 1. Additional figure and tables.
Additional file 1 of Pericoronary adipose tissue attenuation predicts compositional plaque changes: a 12-month longitudinal study in individuals with type 2 diabetes without symptoms or known coronary artery disease
Creators: name: Overgaard, Katrine Schultz
name: Andersen, Thomas Rueskov
name: Heinsen, Laurits Juhl
name: Pararajasingam, Gokulan
name: Mohamed, Roda Abdulkadir
name: Madsen, Freja Sønder
name: Biesenbach, Irmelin Irene Aagaard
name: Højlund, Kurt
name: Lambrechtsen, Jess
name: Auscher, Søren
name: Egstrup, Kenneth
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Hematology

description: Supplementary Material 1
Exotics from Heavy Ion Collisions
Creators: name: ExHIC Collaboration
name: Ohnishi, Akira
name: Cho, Sungtae
name: Furumoto, Takenori
name: Hyodo, Tetsuo
name: Jido, Daisuke
name: Ko, Che Ming
name: Lee, Su Houng
name: Nielsen, Marina
name: Sekihara, Takayasu
name: Yasui, Shigehiro
name: Yazaki, Koichi
Publisher: name: arXiv
Year: 2011
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Discriminating hadronic molecular and multi-quark states is a long standing problem in hadronic physics. We propose here to utilize relativistic heavy ion collisions to resolve this problem, as exotic hadron yields are expected to be strongly affected by their structures. Using the coalescence model, we find that the exotic hadron yield relative to the statistical model result is typically an order of magnitude smaller for a compact multi-quark state, and larger by a factor of two or more for a loosely bound hadronic molecule. We further find that some of the newly proposed heavy exotic states could be produced and realistically measured at RHIC and LHC.
description: Presented at International Conference on the Structure of Baryons (Baryons '10), Osaka, Japan, Dec.7-11, 2010
Additional file 1 of ACTION-1: study protocol for a randomised controlled trial on ACT-guided heparinization during open abdominal aortic aneurysm repair
Creators: name: Wiersema, Arno M.
name: Roosendaal, Liliane C.
name: Koelemaij, Mark J. W.
name: Tijssen, Jan G. P.
name: van Dieren, Susan
name: Blankensteijn, Jan D.
name: Debus, E. Sebastian
name: Middeldorp, Saskia
name: Heyligers, Jan M. M.
name: Fokma, Ymke S.
name: Reijnen, Michel M. P. J.
name: Jongkind, Vincent
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1:. Ethical approval document, official English summary included.
Additional file 2 of ACTION-1: study protocol for a randomised controlled trial on ACT-guided heparinization during open abdominal aortic aneurysm repair
Creators: name: Wiersema, Arno M.
name: Roosendaal, Liliane C.
name: Koelemaij, Mark J. W.
name: Tijssen, Jan G. P.
name: van Dieren, Susan
name: Blankensteijn, Jan D.
name: Debus, E. Sebastian
name: Middeldorp, Saskia
name: Heyligers, Jan M. M.
name: Fokma, Ymke S.
name: Reijnen, Michel M. P. J.
name: Jongkind, Vincent
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2:. Original funding documentation.
The Deterministic Dendritic Cell Algorithm
Creators: name: Greensmith, Julie
name: Aickelin, Uwe
Publisher: name: arXiv
Year: 2010
Subjects: subject: Artificial Intelligence (cs.AI)
subject: Neural and Evolutionary Computing (cs.NE)
subject: FOS: Computer and information sciences

description: The Dendritic Cell Algorithm is an immune-inspired algorithm orig- inally based on the function of natural dendritic cells. The original instantiation of the algorithm is a highly stochastic algorithm. While the performance of the algorithm is good when applied to large real-time datasets, it is difficult to anal- yse due to the number of random-based elements. In this paper a deterministic version of the algorithm is proposed, implemented and tested using a port scan dataset to provide a controllable system. This version consists of a controllable amount of parameters, which are experimented with in this paper. In addition the effects are examined of the use of time windows and variation on the number of cells, both which are shown to influence the algorithm. Finally a novel metric for the assessment of the algorithms output is introduced and proves to be a more sensitive metric than the metric used with the original Dendritic Cell Algorithm.
description: 12 pages, 1 algorithm, 1 figure, 2 tables, 7th International Conference on Artificial Immune Systems (ICARIS 2008)
Additional file 1 of Getting ON-TRAC, a team-centred design study of a reflexivity aid to support resuscitation teams’ information sharing
Creators: name: Mommers, Lars
name: Wulterkens, Dennie
name: Winkel, Steven
name: van den Bogaard, Bas
name: Eppich, Walter J.
name: van Mook, Walther N. K. A.
Publisher: name: figshare
Year: 2025
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences

description: Supplementary material 1. Overview cognitive aids used during cardiopulmonary resuscitation [128–176]
F. W. De KIerk, The Last White President of South Africa, and the Logic of Apartheid. Text of a podcast.
Creators: name: Stockton, Ronald R.
Publisher: name: My University
Year: 2022
Subjects: subject: South Africa, apartheid, ANC, De Klerk, Mandela, Afrikaaners, broederbund, Stellenbosch, verligte, verkrampte, Nelson Mandela, P. W. Botha, Homelands, Transkei, Zululand, ethnic conflict,
subject: Social Sciences
subject: Political Science
subject: FOS: Political science

description: A discussion of how F. W. De Klerk, the last white president of South Africa, evolved in his thinking to realize that he could accept majority rule, work with Nelson Mandela, and still protect the rights of the white minority.
Revisiting Langer-Ambegaokar-McCumber-Halperin theory of resistive transitions in one-dimensional superconductors with exact solutions
Creators: name: Joshi, Darshan G.
name: Bhattacharyay, A.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We present an important correction to the Langer-Ambegaokar-McCumber-Halperin theory for the resistive state of a 1D superconductor. We establish that the identification of the saddle on the free energy surface over which Langer and Ambegaokar had claimed the system to move in order to form thermally excited phase slip centres is wrong. With the help of an exact solution we show that the system has to overcome a similar free energy barrier but can actually have vanishing amplitude of superconducting phase at a point unlike the Langer-Ambegaokar solution.
MOESM1 of The Core-Shell Heterostructure CNT@Li2FeSiO4@C as a Highly Stable Cathode Material for Lithium-Ion Batteries
Creators: name: Peng, Tao
name: Guo, Wei
name: Zhang, Yingge
name: Wang, Yangbo
name: Zhu, Kejia
name: Guo, Yan
name: Wang, Yinghui
name: Lu, Yang
name: Yan, Hailong
Publisher: name: figshare
Year: 2019
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Figure S1. (a) SEM image of CNT, (b) SEM of CNT@SiO2. Figure S2. Thermogravimetry of CNT@Li2FeSiO4 and CNT@Li2FeSiO4@C. Figure S3. The dQ/dV vs. voltage plots of CNT@Li2FeSiO4@C at 0.2 C. Figure S4. The Nyquist plot of CNT@Li2FeSiO4 and CNT@Li2FeSiO4@C electrode and the equivalent circuit for electrodes.
Transverse Spin Physics at COMPASS
Creators: name: Schill, Christian
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The investigation of transverse spin and transverse momentum effects in deep inelastic scattering is one of the key physics programs of the COMPASS collaboration. Three channels have been analyzed at COMPASS to access the transversity distribution function: The azimuthal distribution of single hadrons, involving the Collins fragmentation function, the azimuthal dependence of the plane containing hadron pairs, involving the two-hadron interference fragmentation function, and the measurement of the transverse polarization of Lambda hyperons in the final state. Azimuthal asymmetries in unpolarized semi-inclusive deep-inelastic scattering give important information on the inner structure of the nucleon as well, and can be used to estimate both the quark transverse momentum k_T in an unpolarized nucleon and to access the so-far unmeasured Boer-Mulders function. COMPASS has measured these asymmetries using spin-averaged 6LiD data.
description: Proceedings of QCD10 conference, Montpellier
First Nations children are still being removed at disproportionate rates. Cultural assumptions about parenting need to change
Creators: name: Krakouer, Jacynta
name: Bhathal, Alexandra
name: Chamberlain, Catherine
name: Beaufils, James C
name: Gray, Paul
name: Corrales, Tatiana
Publisher: name: La Trobe
Year: 2022

description: No description supplied
Large Transport Critical Current Densities of Ag Sheathed (Ba,K)Fe2As2+Ag Superconducting Wires Fabricated by an ex-situ Powder-in-Tube (PIT) Process
Creators: name: Togano, Kazumasa
name: Matsumoto, Akiyoshi
name: Kumakura, Hiroaki
Publisher: name: arXiv
Year: 2011
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We report large transport critical current densities observed in Ag-added (Ba,K)Fe2As2 superconducting wires prepared by an ex-situ powder-in-tube (PIT) process. The wire has a simple composite structure sheathed only by Ag. A precursor bulk material prepared by a melting process was ground into powder and put into a Ag tube. The composite was then cold worked into a wire and heat treated at 850$^\circ$C for sintering. Transport critical current densities, Jc, at 4.2 K are 1.0\times104 A/cm2 (Ic = 60.7 A) in self field and 1.1\times103 A/cm2 (Ic = 6.6 A) in 10 T. These are the highest values reported so far for the Fe-based superconducting wires.
description: in press for Appl. Phys. Express
Additional file 2 of Getting ON-TRAC, a team-centred design study of a reflexivity aid to support resuscitation teams’ information sharing
Creators: name: Mommers, Lars
name: Wulterkens, Dennie
name: Winkel, Steven
name: van den Bogaard, Bas
name: Eppich, Walter J.
name: van Mook, Walther N. K. A.
Publisher: name: figshare
Year: 2025
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences

description: Supplementary material 2. Iterative TRAC design over time
Additional file 3 of ACTION-1: study protocol for a randomised controlled trial on ACT-guided heparinization during open abdominal aortic aneurysm repair
Creators: name: Wiersema, Arno M.
name: Roosendaal, Liliane C.
name: Koelemaij, Mark J. W.
name: Tijssen, Jan G. P.
name: van Dieren, Susan
name: Blankensteijn, Jan D.
name: Debus, E. Sebastian
name: Middeldorp, Saskia
name: Heyligers, Jan M. M.
name: Fokma, Ymke S.
name: Reijnen, Michel M. P. J.
name: Jongkind, Vincent
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 3:. English translation of original funding documentation.