cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Statewide mental health training for probation officers: improving knowledge and decreasing stigma
Creators: name: Ghezzi, Marilyn A
name: Wilson, Amy
name: Cuddeback, Gary
name: Burgin, Stacey
name: Van Deinse, Tonya B
name: Tomar, Nikhil
name: Brinkley-Rubinstein, Lauren
Publisher: name: Springer Berlin Heidelberg
Year: 2017

description: Abstract Background The large and growing number of probationers with mental illnesses pose significant challenges to the probationer officers who supervise them. Stigma towards mental illnesses among probation officers is largely unstudied and the effectiveness of training initiatives designed to educate probation officers about mental illness is unknown. To address these gaps in the literature, we report findings from a statewide mental health training initiative designed to improve probation officers’ knowledge of mental illnesses. A single-group pretest posttest design was used and data about stigma towards mental illnesses and knowledge of mental illnesses were collected from 316 probation officers. Data were collected prior to and shortly after officers viewed a series of educational training modules about mental illnesses. Results Officers’ knowledge of mental illnesses increased and officers demonstrated lower levels of stigma towards persons with mental illnesses as evidenced by scores on a standardized scale. Conclusion Mental health education can help decrease stigma and increase knowledge of mental illnesses among probation officers. More research is needed to assess the impact of these trainings on probationers’ mental health and criminal justice outcomes.
The genome assembly of sweet corn RC
Creators: name: 李坤(Kun Li)
Publisher: name: CNGB
Year: 2023
Subjects: Genome sequencing and assembly
Raw sequence reads
Assembly
Monoisolate
Agricultural

description: Using Nanopore long reads, Illumina short reads to assemble the genome of sweet corn inbred line, RC. The genome assembly of sweet corn RC with HI-C data.
Contraceptive use and pregnancy rates among women receiving antiretroviral therapy in Malawi: a retrospective cohort study
Creators: name: Phiri, Sam
Publisher: name: BioMed Central
Year: 2018

description: Abstract Background In 2011, family planning (FP) services were integrated at Martin Preuss Centre (MPC), in urban Lilongwe, Malawi. To date, no previous study evaluated pregnancy rates among HIV-positive women after the integration of FP services into HIV care at the facility. In this study, we investigated whether integration of FP services into HIV clinical care led to increased use of contraceptives and decreased pregnancy rates. Methods This was a retrospective cohort analysis of HIV-positive women from 15 to 49 years of age who accessed antiretroviral therapy (ART) services at MPC. Ascertainment of FP needs, contraceptive methods and pregnancy status were done at ART initiation, and at each ART follow-up visit. Women were offered a wide range of contraceptive methods. Outcomes of interest were contraceptive use and rate of pregnancy. Incident pregnancy was ascertained through patient self-reports during clinic consultation. Trends of contraceptive use and pregnancy rates were analyzed using chi-square (χ2). Results A total of 10,472 women were included in the analysis and contributed 15,700 person-years of observation. Contraceptive use among all women receiving ART increased from 28% in 2012 to 62% in 2016 (p < 0.001). A total of 501 pregnancies occurred, including 13 multiple pregnancies, resulting in an overall pregnancy rates of 3.2 per 100 person-years. Rates of pregnancy decreased from 6.8 per 100 person-years in 2012 to 1.3 per 100 person-years in 2016 (p < 0.001). Conclusion Integration of FP services into HIV care resulted in increased contraceptive use and, subsequently, decreased pregnancy rates in women receiving ART. HIV programs should consider offering FP services to women who are receiving ART.
France new regions planning? Better order or more disorder ?
Creators: name: Ausloos, Marcel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: Applications (stat.AP)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: This paper grounds the critique of the 'reduction of regions in a country' not only in its geographical and social context but also in its entropic space. The various recent plans leading to the reduction of the number of regions in metropolitan France are discussed, based on the mere distribution in the number of cities in the plans and analyzed according to various distribution laws. Each case, except the present distribution with 22 regions, on the mainland, does not seem to fit presently used theoretical models. Beside, the number of inhabitants is examined in each plan. The same conclusion holds. Therefore a theoretical argument based on entropy considerations is proposed, thereby pointing to whether more order or less disorder is the key question, - discounting political considerations.
description: 13 pages; 5 Tables; 8 figures; 28 references; prepared for and to be published in Entropy
Turkiya, Suriya va Iroq munosabatlarida suv resurslari muammosi
Creators: name: Abdujabborov, Akmal
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 380110
subject: International economics
classificationCode: 400513
subject: Water resources engineering

description: The article in Uzbek in analyzes the importance of water resources, a source of conflict in Turkey, Syria and Iraq. The role of of the Euphrates and Tigris in the Middle East is highlighted. The causes of conflicts in international relations arising from the improper management of water resources are analyzed.
Maximum mass, moment of inertia and compactness of relativistic stars
Creators: name: Breu, Cosima
name: Rezzolla, Luciano
Publisher: name: arXiv
Year: 2016
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: A number of recent works have highlighted that it is possible to express the properties of general-relativistic stellar equilibrium configurations in terms of functions that do not depend on the specific equation of state employed to describe matter at nuclear densities. These functions are normally referred to as "universal relations" and have been found to apply, within limits, both to static or stationary isolated stars, as well as to fully dynamical and merging binary systems. Further extending the idea that universal relations can be valid also away from stability, we show that a universal relation is exhibited also by equilibrium solutions that are not stable. In particular, the mass of rotating configurations on the turning-point line shows a universal behaviour when expressed in terms of the normalised Keplerian angular momentum. In turn, this allows us to compute the maximum mass allowed by uniform rotation, M_{max}, simply in terms of the maximum mass of the nonrotating configuration, M_{TOV}, finding that M_{max} ~ (1.203 +- 0.022) M_{TOV} for all the equations of state we have considered. We further show that a universal relation can be found between the dimensionless moment of inertia and the stellar compactness. Although this relation is not surprising as it involves two quantities that have been shown to exhibit universal behaviour with other stellar properties, our parameterisation represents a refinement over a similar relation by Lattimer and Schutz (2005), where a different normalisation was used, and could provide an accurate tool to constrain the equation of state of nuclear matter when measurements of the moment of inertia become available.
description: v2 matches version published on MNRAS
Indoor air pollution exposure from use of indoor stoves and fireplaces in association with breast cancer: a case-control study
Creators: name: Gammon, Marilie D.
name: White, Alexandra J
name: McCarty, Kathleen M
Publisher: name: BioMed Central
Year: 2014

description: Abstract Background Previous studies suggest that polycyclic aromatic hydrocarbons (PAHs) may adversely affect breast cancer risk. Indoor air pollution from use of indoor stoves and/or fireplaces is an important source of ambient PAH exposure. However, the association between indoor stove/fireplace use and breast cancer risk is unknown. We hypothesized that indoor stove/fireplace use in a Long Island, New York study population would be positively associated with breast cancer and differ by material burned, and the duration and timing of exposure. We also hypothesized that the association would vary by breast cancer subtype defined by p53 mutation status, and interact with glutathione S-transferases GSTM1, T1, A1 and P1 polymorphisms. Methods Population-based, case-control resources (1,508 cases/1,556 controls) were used to conduct unconditional logistic regression to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI). Results Breast cancer risk was increased among women reporting ever burning synthetic logs (which may also contain wood) in their homes (OR = 1.42, 95% CI 1.11, 1.84), but not for ever burning wood alone (OR = 0.93, 95% CI 0.77, 1.12). For synthetic log use, longer duration >7 years, older age at exposure (>20 years; OR = 1.65, 95% CI 1.02, 2.67) and 2 or more variants in GSTM1, T1, A1 or P1 (OR = 1.71, 95% CI 1.09, 2.69) were associated with increased risk. Conclusions Burning wood or synthetic logs are both indoor PAH exposure sources; however, positive associations were only observed for burning synthetic logs, which was stronger for longer exposures, adult exposures, and those with multiple GST variant genotypes. Therefore, our results should be interpreted with care and require replication.
Plasmon dissipation in gapped-graphene open systems at finite temperature
Creators: name: Iurov, Andrii
name: Gumbs, Godfrey
name: Huang, Danhong
name: Silkin, V. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Numerical and closed-form analytic expressions for plasmon dispersion relations and rates of dissipation are first obtained at finite-temperatures for free-standing gapped graphene. These closed-system results are generalized to an open system with Coulomb coupling of graphene electrons to an external electron reservoir. New plasmon modes, as well as new plasmon dissipation channels, are found in this open system, including significant modifications arising from the combined effect of thermal excitation of electrons and an energy bandgap in gapped graphene. Moreover, the characteristics of the new plasmon mode and the additional plasmon dissipation may be fully controlled by adjusting the separation between the graphene layer from the surface of a thick conductor. Numerical results for the thermal shift of plasmon frequency in a doped gapped graphene layer, along with its sensitivity to the local environment, are demonstrated and analyzed. Such phenomenon associated with the frequency shift of plasmons may be applied to direct optical measurement of local electron temperature in transistors and nanoplasmonic structures.
description: 16 pages, 7 figures
Mechanical properties of hoof horn, sole haemorrhage and lameness in dairy cattle
Creators: name: Winkler, Betina
Publisher: name: University of Plymouth
Year: 2005

description: Merged with duplicate record 10026.1/859 on 27.03.2017 by CS (TIS)
description: The present study aimed to develop a method to measure changes in the mechanical properties of the sole and white line hoof horn that should be used in vivo and to examine the hypothesis that the presence of haemorrhages in the horn would represent a weakening of the structural strength of the horn. Hoof horn samples were collected from the sole and white line areas of the hoof horn of dairy cattle. The maximum punch force, work to fracture, elastic modulus and membrane stress were measured through the use of a punch test and the elastic modulus was measured through the use of a tension test. The elastic modulus of the diaphragm, membrane stress and elastic modulus measured through tension test of the sole and white line areas were found to increase significantly and exponentially (P<0.01, R²adj. = 0.39 to 0.81) and the punch force and work to fracture increased significantly and linearly (P<0.01, R²adj. = 0.37 to 0.89) in relation to the dry matter content of the hoof horn. Sample thickness accounted for 30 to 40 % of the variation of the punch force and work to fracture results, therefore the thickness of the tested area was measured and included as a covariant in the statistical analysis of those tests. Punch force of the sole area of the claw horn decreased significantly (P<0.001) (8.72, 8.53, 8.06, 7.75, 6.08, 4.99 N, sem 0.078 to 0.460) when haemorrhage levels of the tested area increased (0 to 5). In multiparous cows that had higher scores for lesions of the claw horn when compared to the heifers the punch force decreased at day 160 postpartum when the cows had greater lesion scores and was lower in hind claws that had higher lesion scores when compared to the front claws. Lower punch force and elastic modulus were found in heifers with less straight rear legs, lower foot angle, poor HUKI locomotion score, lower scores for the composite trait legs and feet and a higher HUKI final total score. The measurement of the mechanical properties of the hoof horn has contributed to the understanding of the changes occurring during the peripartum period that predispose dairy cows to acquire horn lesions and suffer from lameness and has proven to be a good method for measuring the influence of housing systems and cow conformation on the strength and elasticity of the horn.
Primordial Power Spectra of EiBI Inflation in Strong Gravity Limit
Creators: name: Cho, Inyong
name: Singh, Naveen K.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We investigate the scalar and the tensor perturbations of the $φ^2$ inflation model in the strong-gravity limit of Eddington-inspired Born-Infeld (EiBI) theory. In order to consider the strong EiBI-gravity effect, we take the value of $κ$ large, where $κ$ is the EiBI theory parameter. The energy density of the Universe at the early stage is very high, and the Universe is in a strong-gravity regime. Therefore, the perturbation feature is not altered from what was investigated earlier. At the attractor inflationary stage, however, the feature is changed in the strong EiBI-gravity limit. The correction to the scalar perturbation in this limit comes mainly via the background matter field, while that to the tensor perturbation comes directly from the gravity ($κ$) effect. The change in the value of the scalar spectrum is little compared with that in the weak EiBI-gravity limit, or in GR. The form of the tensor spectrum is the same with that in the weak limit, but the value of the spectrum can be suppressed down to zero in the strong limit. Therefore, the resulting tensor-to-scalar ratio can also be suppressed in the same way, which makes $φ^2$ model in EiBI theory viable.
description: 10 pages, 1 figure
title: Proclamation speech to City Council, no.2
Creators: name: Schoen, Tina
name: Stebner, Brenda
Publisher: name: Electronic version published by Vancouver Island University
Year: 2003
Subjects: subject: Speeches, addresses, etc.

description: A speech to proclaim Gay Pride Week by Tina Schoen and Brenda Stebner made to Nanaimo City Council.
Efficiency clustering for low-density microarrays and its application to QPCR
Creators: name: Lock, Eric F
name: Marron, JS
name: Ziemiecki, Ryan
name: Dittmer, Dirk
Publisher: name: BioMed Central Ltd
Year: 2010

description: Abstract Background Pathway-targeted or low-density arrays are used more and more frequently in biomedical research, particularly those arrays that are based on quantitative real-time PCR. Typical QPCR arrays contain 96-1024 primer pairs or probes, and they bring with it the promise of being able to reliably measure differences in target levels without the need to establish absolute standard curves for each and every target. To achieve reliable quantification all primer pairs or array probes must perform with the same efficiency. Results Our results indicate that QPCR primer-pairs differ significantly both in reliability and efficiency. They can only be used in an array format if the raw data (so called CT values for real-time QPCR) are transformed to take these differences into account. We developed a novel method to obtain efficiency-adjusted CT values. We introduce transformed confidence intervals as a novel measure to identify unreliable primers. We introduce a robust clustering algorithm to combine efficiencies of groups of probes, and our results indicate that using n < 10 cluster-based mean efficiencies is comparable to using individually determined efficiency adjustments for each primer pair (N = 96-1024). Conclusions Careful estimation of primer efficiency is necessary to avoid significant measurement inaccuracies. Transformed confidence intervals are a novel method to assess and interprete the reliability of an efficiency estimate in a high throughput format. Efficiency clustering as developed here serves as a compromise between the imprecision in assuming uniform efficiency, and the computational complexity and danger of over-fitting when using individually determined efficiencies.
Half vortex and fractional electrical charge in two dimensions
Creators: name: Roy, Bitan
name: Herbut, Igor F.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Despite fermion doubling, a two-dimensional quasi-relativistic spin-1/2 system can still lead to true fractionalization of electrical charge, when a massive ordered phase supports a "half-vortex". Such topological defect is possible when the order parameter in form of Dirac mass is described by two $U(1)$ angles, and each of them winds by an angle $π$ around a point. We demonstrate that such a mass configuration in an eight-dimensional Dirac Hamiltonian exhibits only a single bound zero mode, and therefore binds the charge of $e/2$. In graphene, for example, such an ordered phase is provided by the easy-plane spin-triplet Kekule valence bond solid. We argue that an application of an in-plane magnetic field can cause an excitonic instability toward such ordered phase, even for weak repulsion, when the on-site, nearest-neighbor and second neighbor components of it are of comparable strengths.
description: 4 Pages, No figure; Published version
title: 	Interdyscyplinarne analizy przedmiotu ekspozycji jako czynnik wpływający na koncepcję ekspozycji w edukacji wystawienniczej
Creators: name: Gyurkovich, Magdalena
Publisher: name: Publishing House of Poznan University of Technology
Year: 2023

description: Zeszyty Naukowe Politechniki Poznańskiej. Architektura, Urbanistyka, Architektura Wnętrz, 13, 23-35
title: Οι διαστάσεις του αντικειμένου σχεδιασμού: σημασιολογικά συστήματα και διαδικασίες στη δυνητικοποίηση του εκθεσιακού χώρου
titleType: AlternativeTitle
title: The dimensions of the design object: semantic systems and processes in the virtualization of the exhibition space
Creators: name: Kiourti, Christina
Publisher: name: National Technological University of Athens
Year: 2025
Subjects: Δυνητικό - ενεργό
Δίκτυο
Διαδικασία - σύστημα
Hjelmslev
Deleuze
Virtual - actual
Process - system
Network

description: Διατμηματικό Πρόγραμμα Μεταπτυχιακών Σπουδών “Έρευνα στην Αρχιτεκτονική: Σχεδιασμός - Χώρος – Πολιτισμός” - Κατ. Α: Γνωσιολογία της Αρχιτεκτονικής
Beyond Endoscopy via the Trace Formula-I: Poisson Summation and Contributions of Special Representations
Creators: name: Altug, Salim Ali
Publisher: name: arXiv
Year: 2015
Subjects: subject: Number Theory (math.NT)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics

description: With analytic applications in mind, in particular Beyond Endoscopy ([13]), we initiate the study of the elliptic part of the trace formula. Incorporating the approximate functional equation to the elliptic part we control the analytic behavior of the volumes of tori that appear in the elliptic part. Furthermore by carefully choosing the truncation parameter in the approximate functional equation we smooth-out the singularities of orbital integrals. Finally by an application of Poisson summation we rewrite the elliptic part so that it is ready to be used in analytic applications, and in particular in Beyond Endoscopy. As a by product we also isolate the contributions of special representations as pointed out in [13].
ZNF280BY and ZNF280AY: autosome derived Y-chromosome gene families in Bovidae
Creators: name: Yang, Yang
Publisher: name: BioMed Central Ltd
Year: 2011

description: Abstract Background Recent progress in exploring the Y-chromosome gene content in humans, mice and cats have suggested that "autosome-to-Y" transposition of the male fertility genes is a recurrent theme during the mammalian Y-chromosome evolution. These transpositions are lineage-dependent. The purpose of this study is to investigate the lineage-specific Y-chromosome genes in bovid. Results We took a direct testis cDNA selection strategy and discovered two novel gene families, ZNF280BY and ZNF280AY, on the bovine (Bos taurus) Y-chromosome (BTAY), which originated from the transposition of a gene block on the bovine chromosome 17 (BTA17) and subsequently amplified. Approximately 130 active ZNF280BY loci (and ~240 pseudogenes) and ~130 pseudogenized ZNF280AY copies are present over the majority of the male-specific region (MSY). Phylogenetic analysis indicated that both gene families fit with the "birth-and-death" model of evolution. The active ZNF280BY loci share high sequence similarity and comprise three major genomic structures, resulted from insertions/deletions (indels). Assembly of a 1.2 Mb BTAY sequence in the MSY ampliconic region demonstrated that ZNF280BY and ZNF280AY, together with HSFY and TSPY families, constitute the major elements within the repeat units. The ZNF280BY gene family was found to express in different developmental stages of testis with sense RNA detected in all cell types of the seminiferous tubules while the antisense RNA detected only in the spermatids. Deep sequencing of the selected cDNAs revealed that different loci of ZNF280BY were differentially expressed up to 60-fold. Interestingly, different copies of the ZNF280AY pseudogenes were also found to differentially express up to 10-fold. However, expression level of the ZNF280AY pseudogenes was almost 6-fold lower than that of the ZNF280BY genes. ZNF280BY and ZNF280AY gene families are present in bovid, but absent in other mammalian lineages. Conclusions ZNF280BY and ZNF280AY are lineage-specific, multi-copy Y-gene families specific to Bovidae, and are derived from the transposition of an autosomal gene block. The temporal and spatial expression patterns of ZNF280BYs in testis suggest a role in spermatogenesis. This study offers insights into the genomic organization of the bovine MSY and gene regulation in spermatogenesis, and provides a model for studying evolution of multi-copy gene families in mammals.
Learning Path and Training Materials on "Open Science and Research Data Management in Solid Earth Sciences" - Training Facilitator Guide
Creators: name: Cocco, Massimo
name: Michalek, Jan
name: Nedrebø, Harald
name: Stuebe, Karl Christian
name: Tanlongo, Federica
Publisher: name: Zenodo
Year: 2024
Subjects: subject: Open Science
subject: Research Data Management
subject: FAIR principles
subject: Data science
subject: European Plate Observing System
subject: EPOS Data Portal
subject: Solid Earth Sciences
subject: Solid Earth Science
subject: Training
subject: OER
subject: Geosciences

description: The purpose of this document is to include all the necessary information regarding the preparation and planning of the training in Open Science and Research Data Management in Solid Earth Sciences. This document is part of the D5.3: Learning Path and Training Materials on "Open Science Research Data Management in Solid Earth Sciences" package
title: Disputed Territory
title: Feminist Studies in Germany and Its Queer Discontents
titleType: Subtitle
Creators: name: Hark, Sabine
Publisher: name: Humboldt-Universität zu Berlin
Year: 2001
Subjects: subject: Queer
subject: Dichotomie
subject: Feminismus
subject: Wissenschaft
subject: Gender
subject: 303 Gesellschaftliche Prozesse

description: When Judith Butler's Gender Trouble appeared in German translation in 1991, the book launched a heated debate among German academic feminists about the status of gender as a category of analysis, and about the future of feminist theory. Tue anxieties were quite fundamental. Is "gender" a category of "nature" or "culture"? And if its "nature" is entirely cultural, a social construction, how can we then speak and act in the name of a gender, i.e., in the name of women? Much of this debate was coded as a conflict between different feminist generations. This trope of "generation" served as a strategy of displacement: "queer issues" figured as a kind of absent/present threat haunting the coherence of Gender Studies as a legitimate field of knowledge, but they were hardly made an explicit subject of discussion. This essay will look at the conscious and unconscious levels of discourse: What is the "positive unconscious" of the socalled "Butler debate"? Who gets to say what and how? What defines an "intelligible" object of study? Who gets to define it? In short, what is the "order of things" that frames discourse? Even if queer theory has had no manifest impact on the definition of Women's and Gender Studies, how did the specter of "queer" structure feminist theory on an unconscious level? And above all, what does all this mean for the future of German academic feminism(s)?
title: Από τα μοναστικά κοινόβια στο χώρο κίνησης: μια ιστορία για την αρχιτεκτονική και την τεχνολογία
titleType: AlternativeTitle
title: From monastery to modern corridor: a tale about architecture and technology
titleType: AlternativeTitle
Creators: name: Efstathiou, Konstantinos
Publisher: name: National Technological University of Athens
Year: 2025
Subjects: Διάδρομος
Hospital
Τεχνολογία
Υγεία
Νοσοκομείο
Μοναστήρι
Schmarsow
Monastery
Loos, Adolf
Technology
Corridor

description: Διατμηματικό Πρόγραμμα Μεταπτυχιακών Σπουδών “Έρευνα στην Αρχιτεκτονική: Σχεδιασμός - Χώρος – Πολιτισμός” - Κατ. Α: Γνωσιολογία της Αρχιτεκτονικής
Identification of Jun loss promotes resistance to histone deacetylase inhibitor entinostat through Myc signaling in luminal breast cancer
Creators: name: Fan, Cheng
name: Mott, Kevin R
name: Hollern, Daniel P
name: Perou, Charles M
name: Tanioka, Maki
name: Darr, David B
Publisher: name: BioMed Central
Year: 2018

description: Abstract
                Background
                Based on promising phase II data, the histone deacetylase inhibitor entinostat is in phase III trials for patients with metastatic estrogen receptor-positive breast cancer. Predictors of sensitivity and resistance, however, remain unknown.
                Methods
                A total of eight cell lines and nine mouse models of breast cancer were treated with entinostat. Luminal cell lines were treated with or without entinostat at their IC50 doses, and MMTV/Neu luminal mouse tumors were untreated or treated with entinostat until progression. We investigated these models using their gene expression profiling by microarray and copy number by arrayCGH. We also utilized the network-based DawnRank algorithm that integrates DNA and RNA data to identify driver genes of resistance. The impact of candidate drivers was investigated in The Cancer Genome Atlas and METABRIC breast cancer datasets.
                Results
                Luminal models displayed enhanced sensitivity to entinostat as compared to basal-like or claudin-low models. Both in vitro and in vivo luminal models showed significant downregulation of Myc gene signatures following entinostat treatment. Myc gene signatures became upregulated on tumor progression in vivo and overexpression of Myc conferred resistance to entinostat in vitro. Further examination of resistance mechanisms in MMTV/Neu tumors identified a portion of mouse chromosome 4 that had DNA copy number loss and low gene expression. Within this region, Jun was computationally identified to be a driver gene of resistance. Jun knockdown in cell lines resulted in upregulation of Myc signatures and made these lines more resistant to entinostat. Jun-deleted samples, found in 17–23% of luminal patients, had significantly higher Myc signature scores that predicted worse survival.
                Conclusions
                Entinostat inhibited luminal breast cancer through Myc signaling, which was upregulated by Jun DNA loss to promote resistance to entinostat in our models. Jun DNA copy number loss, and/or high MYC signatures, might represent biomarkers for entinostat responsiveness in luminal breast cancer.
Dynamics of cinacalcet use and biochemical control in hemodialysis patients: a retrospective New-user cohort design
Creators: name: Kshirsagar, Abhijit
name: Brookhart, M. Alan
name: Reams, B. D
Publisher: name: BioMed Central
Year: 2015

description: Abstract Background Cinacalcet is used to treat secondary hyperparathyroidism among hemodialysis patients. Large-scale epidemiologic studies describing patterns of cinacalcet use, effects on parathyroid hormone (PTH), calcium, and phosphorous levels, and predictors of discontinuation have not been previously reported. Methods This retrospective cohort study used a clinical database of a large U.S. dialysis provider (2007–2010) merged with administrative data from the United States Renal Data System. Among new users of cinacalcet with Medicare coverage, trends in PTH, calcium, and phosphorus were measured in 30-day intervals following cinacalcet initiation. Results Seventeen thousand seven hundred sixty-three eligible initiators contributed 111,047 30-day follow-up intervals. Of these, 56 % discontinued cinacalcet by month 4. Of those discontinuing, 76.3 % reinitiated. Mean values of PTH, calcium, and phosphorus decreased to recommended levels within 4 months following initiation. Proximal PTH levels <150 pg/mL were associated with discontinuation: HR = 1.23 (95 % CI: 1.12, 1.36), whereas low calcium (<7.5 mg/dL) was suggestive of an association, HR = 1.09 (95 % CI 0.91, 1.32). Being in the Part D gap period increased discontinuation risk: HR = 1.09 (95 % CI: 1.03, 1.16). Low-income subsidy status decreased discontinuation risk: HR = 0.77 (95 % CI 0.69, 0.86). Predictors of reinitiation included low-income subsidy, HR = 1.32 (95 % CI 1.22, 1.43); higher albumin level, HR = 1.23 (95 % CI 1.10, 1.36) and higher calcium level, HR = 1.26 (95 % CI 1.19, 1.33). Conclusions Substantial and expected declines in laboratory values occurred following cinacalcet initiation. Early discontinuation and reinitiation of cinacalcet were common and may have occurred for clinical and economic reasons.
National Trust Arts, Buildings & Collections Bulletin, Summer 2009
Creators: name: National Trust
Publisher: name: National Trust
Year: 2009
Subjects: subject: Garden history
subject: Plant collections
subject: Collections
subject: Architectural history
subject: Arts
subject: Curation
subject: Historic families
subject: Curation & Experience
subject: Books and libraries
subject: Conservation
subject: Architecture
subject: FOS: Civil engineering

description: The Arts, Buildings & Collections (ABC) Bulletin was published between 2006 and 2022, aimed at external readers with an interest in conservation and curatorial work. ABC was distributed in PDF format as an email attachment to direct subscribers, relevant National Trust staff and volunteers, and was available to download from the Trust website. Each issue was around 35 pages, colour-illustrated, with around five scholarly articles and three shorter features covering NT exhibitions and events, new publications, conservation news, acquisitions, loans, etc. Publication continued until 2022, when the Bulletin was replaced by the Cultural Heritage Magazine.
description: Swindon, UK
Constraining conformal field theories with a higher spin symmetry in d> 3 dimensions
Creators: name: Alba, Vasyl
name: Diab, Kenan
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We study unitary conformal field theories with a unique stress tensor and at least one higher-spin conserved current in d>3 dimensions. We prove that every such theory contains an infinite number of higher-spin conserved currents of arbitrarily high spin, and that Ward identities generated by the conserved charges of these currents imply that the correlators of the stress tensor and the conserved currents of the theory must coincide with one of the following three possibilities: a) a theory of n free bosons (for some integer n), b) a theory of n free fermions, or c) a theory of n (d-2)/2-forms. For d even, all three structures exist, but for d odd, it may be the case that the third structure (c) does not; if it does exist, it is unclear what theory, if any, realizes it. This is a generalization of the result proved in three dimensions by Maldacena and Zhiboedov [arXiv:1112.1016]. This paper supersedes the previous paper by the authors [arXiv:1307.8092]
description: 40 pages, This paper supersedes the previous paper arXiv:1307.8092 by the authors
Well-posedness for compressible MHD system with highly oscillating initial data
Creators: name: Jia, Junxiong
name: Peng, Jigen
name: Gao, Jinghuai
Publisher: name: arXiv
Year: 2015
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: In this paper, we transform compressible MHD system written in Euler coordinate to Lagrange coordinate in critical Besov space. Then we construct unique local solutions for compressible MHD system. Our results improve the range of Lebesgue exponent in Besov space from $[2, N)$ to $[2, 2N)$ with $N$ stands for dimension. In addition, we give a lower bound for the maximal existence time which is important for our construction of global solutions. Based on the local solution, we obtain a unique global solution with high oscillating initial velocity and density by using effective viscous flux and Hoff's energy methods to explore the structure of compressible MHD system.
description: 44 pages
Analysis of nuclear fiber cell compaction in transparent and cataractous diabetic human lenses by scanning electron microscopy
Creators: name: Freel, Christopher D
name: Costello, Joeseph
Publisher: name: BioMed Central Ltd
Year: 2003

description: Abstract: Background: Compaction of human ocular lens fiber cells as a function of both aging and cataractogenesis has been demonstrated previously using scanning electron microscopy. The purpose of this investigation is to quantify morphological differences in the inner nuclear regions of cataractous and non-cataractous human lenses from individuals with diabetes. The hypothesis is that, even in the presence of the osmotic stress caused by diabetes, compaction rather than swelling occurs in the nucleus of diabetic lenses. Methods: Transparent and nuclear cataractous lenses from diabetic patients were examined by scanning electron microscopy (SEM). Measurements of the fetal nuclear (FN) elliptical angles (anterior and posterior), embryonic nuclear (EN) anterior-posterior (A-P) axial thickness, and the number of EN fiber cell membrane folds over 20 μm were compared. Results: Diabetic lenses with nuclear cataract exhibited smaller FN elliptical angles, smaller EN axial thicknesses, and larger numbers of EN compaction folds than their non-cataractous diabetic counterparts. Conclusion: As in non-diabetic lenses, the inner nuclei of cataractous lenses from diabetics were significantly more compacted than those of non-cataractous diabetics. Little difference between diabetic and non-diabetic compaction levels was found, suggesting that diabetes does not affect the degree of compaction. However, consistent with previous proposals, diabetes does appear to accelerate the formation of cataracts that are similar to age-related nuclear cataracts in nondiabetics. We conclude that as scattering increases in the diabetic lens with cataract formation, fiber cell compaction is significant.
Energies for cyclic and acyclic aggregations of adamantane and diamantane units sharing vertices, edges, or six-membered rings
Creators: name: Balaban, Alexandru T.
name: Bhattacharya, Debojit
name: Klein, Douglas J.
name: Ortiz, Yenni P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Diamondoids are hydrocarbons having a carbon scaffold comprised from polymer-like composites of adamantane cages. The present paper describes computed total energies and "SWB-tension" energies (often referred to as "strain" energies) for species having $n$ adamantane or diamantane units sharing pairwise: one carbon atom (spiro-[n]adamantane or spiro-[$n$]diamantane); one C-C bond (one-bond-sharing-[$n$]adamantane or one-bond-sharing-[$n$]diamantane); or one chair-shaped hexagon of carbon atoms (1234-helical-cata-[$n$]diamantanes). Each of the five investigated polymer-like types is considered either as an acyclic or a cyclic chain of adamantane- or diamantane-unit cages. With increasing $n$ values, SWB-tension energies for acyclic aggregates are found to increase linearly, while the net SWB-tension energies of cyclic aggregates often go thru a minimum at a suitable value of $n$. In all five cases, a limiting common energy per unit ($E/n$ ) is found to be approached by both cyclic and acyclic chains as $n\to \infty $, as revealed from plots of $E/n$ versus $1/n$ for acyclic chains and of $E/n$ versus $1/n^2$ for cyclic chains.
description: submitted to Int J. Quantum Chemistry
Effects of trauma-focused psychotherapies for PTSD on interpersonal functioning: A systematic review and meta-analysis of randomized clinical trials
Creators: name: Swerdlow, Benjamin
name: Baker, Shelby
name: Straud, Casey
name: Rozek, David
name: Sippel, Lauren
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences
subject: Interpersonal functioning
subject: Meta-analysis
subject: Post-traumatic stress disorder
subject: PTSD

description: A systematic review and meta-analysis of the effects of first-line, trauma-focused psychotherapies on interpersonal functioning.
Reconciling transport models across scales: the role of volume exclusion
Creators: name: Taylor, Paul R.
name: Yates, Christian A.
name: Simpson, Matthew J.
name: Baker, Ruth E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantitative Methods (q-bio.QM)
subject: FOS: Biological sciences

description: Diffusive transport is a universal phenomenon, throughout both biological and physical sciences, and models of diffusion are routinely used to interrogate diffusion-driven processes. However, most models neglect to take into account the role of volume exclusion, which can significantly alter diffusive transport, particularly within biological systems where the diffusing particles might occupy a significant fraction of the available space. In this work we use a random walk approach to provide a means to reconcile models that incorporate crowding effects on different spatial scales. Our work demonstrates that coarse-grained models incorporating simplified descriptions of excluded volume can be used in many circumstances, but that care must be taken in pushing the coarse-graining process too far.
Vaccine Communication Relating to Safety and Efficacy of Vaccine to Pregnant and Breastfeeding Mothers in the Philippines
Creators: name: Alub, Karen
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: Medical Education
subject: Health and Medical Administration
subject: Breastfeeding
subject: COVID-19
subject: Medical Education
subject: Pregnancy
subject: Vaccination

description: A review on how online and on-site public platforms in the Philippines share information regarding COVID-19 vaccination for pregnant and breastfeeding mothers.
ОБЗОР СОЦИАЛЬНО-ЭКОНОМИЧЕСКИХ МОДЕЛЕЙ МНОГОУРОВНЕВОГО УПРАВЛЕНИЯ И ФИНАНСИРОВАНИЯ ДЕЦЕНТРАЛИЗОВАННЫХ МЕРОПРИЯТИЙ ПО СОТРУДНИЧЕСТВУ В ОБЛАСТИ РАЗВИТИЯ
Creators: name: Abdujabborov, Akmal
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 380118
subject: Urban and regional economics
classificationCode: 330406
subject: Regional analysis and development

description: This research paper examines several aspects of multi-level governance and financing for decentralised development cooperation activities. In order to ensure informativeness, the presented synopses employ cause-and-effect relationships between assertions.
The Product Manager’s Role & Responsibility in the Context of Social Values
Creators: name: Ari, Eilat
name: Toch, Eran
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Operational Research
subject: Work, Economy and Organizations
subject: Operations Research, Systems Engineering and Industrial Engineering
subject: Engineering Education
subject: Industrial Engineering
subject: Quantitative, Qualitative, Comparative, and Historical Methodologies
subject: Social and Behavioral Sciences
subject: Sociology
subject: FOS: Sociology
subject: Engineering
subject: Product Management

description: Online survey to investigate whether product manager’s decision-making is shaped by ethical factors on a larger scale.
Computational Thinking in Early Childhood Education: Protocol for a Systematic Review on its Components and Operationalizations
Creators: name: Hao, LI
name: Jie, Liu
name: Xiao, Zhang
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Education
subject: Early Childhood Education
subject: Computational Thinking
subject: Early Childhood Education
subject: Systematic Review

description: This systematic review project aims to identify what computational thinking components have been incorporated and explore how they have been operationalized in the curriculums, interventions, and assessments for preschoolers. The manuscript of the systematic review protocol can be found in the preregistration folder.
Measuring decision quality: psychometric evaluation of a new instrument for breast cancer chemotherapy
Creators: name: Lee, Clara N
Publisher: name: BioMed Central Ltd
Year: 2014

description: Abstract Background Women diagnosed with early stage (I or II) breast cancer face a highly challenging decision – whether or not to undergo adjuvant chemotherapy. We developed a decision quality instrument for chemotherapy for early stage breast cancer and sought to evaluate its performance. Methods Cross-sectional, mailed survey of recent breast cancer survivors, providers, and healthy controls and a retest survey of survivors. The decision quality instrument includes questions on knowledge and personal goals. It results in a knowledge score and concordance score, which reflects the percentage of patients who received treatments that match their goals. Hypotheses related to acceptability, feasibility, validity, and reliability of the survey instrument were examined. Results Responses were received from 352 patients, 89 providers and 35 healthy controls. The decision quality instrument was feasible to implement with few missing data. The knowledge scores had good retest reliability (intraclass correlation coefficient (ICC) =0.75). Knowledge scores discriminated between providers and patients (mean difference 31.1%, 95% CI 26.9, 35.3) and between patients and healthy controls (mean difference 11.2, 95% CI 5.4, 17.1). Most providers reported that the knowledge items covered essential content. Two of the five goal items had a ceiling effect, and one goal had low content validity. The goal items had moderate retest reliability (ICC’s 0.57 to 0.78). In the multivariable model of treatment, none of the patient goals was associated with receipt of chemotherapy. Age and hormone receptor status were the only variables independently associated with chemotherapy. Most patients (77.6%) had treatment concordant with that predicted by the model. Patients who had concordant treatment had similar levels of confidence and regret as those who did not. Conclusions The Decision Quality Instrument is a reliable and valid measure of patient knowledge about chemotherapy, but its ability to measure concordance with patient goals is limited. In this sample, patient goals were not associated with treatment, and most patients reported they were not asked their preference, suggesting that goals were not adequately considered in decision making.
Social Media and Well-being
Creators: name: Rose, Hope
name: King, Laura
name: Sanders, Christopher
name: Wang, Irene
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: This study is intended to study how social media use is related to well-being. We predict that those who are higher in psychological richness, and who prefer to lead a psychologically rich life, will follow more diverse social media accounts. Additionally, we predict that those who are higher in subjective well-being, and who prefer to lead a happy, will follow accounts that are more narrowed in interest, and closely align with their own values.
title: Family Allotment Gardens in the Structure of Poznan City and Their Role in Adaptation to Climate Change
Creators: name: Januchta-Szostak, Anna
name: Zieleniewska, Julia
name: Kubacka, Monika
Publisher: name: Publishing House of Poznan University of Technology
Year: 2023

description: Zeszyty Naukowe Politechniki Poznańskiej. Architektura, Urbanistyka, Architektura Wnętrz, 13, 37-58
Heading Down the Wrong Pathway: on the Influence of Correlation within Gene Sets
Creators: name: Gatti, Daniel M
name: Wright, Fred A.
name: Nobel, Andrew
name: Rusyn, Ivan
Publisher: name: BioMed Central Ltd
Year: 2010

description: Abstract Background Analysis of microarray experiments often involves testing for the overrepresentation of pre-defined sets of genes among lists of genes deemed individually significant. Most popular gene set testing methods assume the independence of genes within each set, an assumption that is seriously violated, as extensive correlation between genes is a well-documented phenomenon. Results We conducted a meta-analysis of over 200 datasets from the Gene Expression Omnibus in order to demonstrate the practical impact of strong gene correlation patterns that are highly consistent across experiments. We show that a common independence assumption-based gene set testing procedure produces very high false positive rates when applied to data sets for which treatment groups have been randomized, and that gene sets with high internal correlation are more likely to be declared significant. A reanalysis of the same datasets using an array resampling approach properly controls false positive rates, leading to more parsimonious and high-confidence gene set findings, which should facilitate pathway-based interpretation of the microarray data. Conclusions These findings call into question many of the gene set testing results in the literature and argue strongly for the adoption of resampling based gene set testing criteria in the peer reviewed biomedical literature.