cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Gamified Learning Application for Students with ADHD in Pakistan: A Learning-Based Experiment
Creators: name: Ali, Muhammad
name: Azeem, Saleha
Publisher: name: GI
Year: 2023

description: This paper explores the use of gamification to improve learning outcomes for students with ADHD in Pakistan. The authors developed a gamified learning app prototype and tested it with 146 students aged 13-17. The results showed that the app was effective in improving students’ concentration, motivation, and learning outcomes. The authors conclude that gamification is a promising approach for improving learning outcomes for students with ADHD in Pakistan and other developing countries. Key findings from the study: (1) Students who used the gamified learning app showed significant improvements in concentration, motivation, and learning outcomes compared to a control group who did not use the app. (2) The app was particularly effective for students who had difficulty staying focused and motivated in traditional learning environments. (3) Thematic analysis of patient’s and their parent’s interviews identified useful app feedback and a range of perceptions.
title: Study of usefulness of the single phase three dimensional multi-detector-row CT angiography imaging using a low tube voltage for hepatectomy preoperative planning in the colorectal cancer liver metastases
Creators: name: Inokuchi, Yasuhiro
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Liver
subject: Vascular
subject: CT-Angiography
subject: CT
subject: Imaging sequences
subject: Surgery
subject: Cancer
subject: Kv imaging

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Nowadays, the treatment of the colorectal cancer liver metastases has been useful hepatectomy, (1, 2) and three dimensionalmulti-detector-row CT angiography (3D-MDCTA) images of the liver by multiphasic imaging is useful to hepatectomypreoperative...
The employment environment for youth in rural South Africa: A mixed-methods study
Creators: name: Thirumurthy, Harsha
name: Halpern, Carolyn T
name: Pettifor, Audrey
name: Wilkinson, Andra
name: Kahn, Kathleen
name: Collinson, Mark A
name: Rosenberg, Molly
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: South Africa has high youth unemployment. This paper examines the predictors of youth employment in rural Agincourt, Mpumalanga Province. A survey of 187 out-of-school 18–24 year olds found only 12% of women and 38% of men were currently employed. Men with skills/training were significantly more likely to report employment, mostly physical labour (aOR: 4.5; CI: 1.3, 15.3). In-depth interviews with 14 of the youth revealed women are perceived more suitable for formal employment, which is scarce informing why women were more likely to pursue further education and yet less likely to be employed. Ten key informants from local organisations highlighted numerous local youth employment resources while, in contrast, all youth in the sample said no resources were available, highlighting a need for the organisations to extend their services into rural areas. As these services are focused on entrepreneurship, programs to increase financial literacy and formal employment opportunities are also needed.
A Case Study of the Sensitivity to LFV Operators with Precision Measurements and the LHC
Creators: name: Cai, Yi
name: Schmidt, Michael A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We compare the sensitivity of precision measurements of lepton flavour observables to the reach of the LHC in a case study of lepton-flavour violating operators of dimension six with two leptons and two quarks. For light quarks precision measurements always yield the more stringent constraints. The LHC complements precision measurements for operators with heavier quarks. Competitive limits can already be set on the cutoff scale $Λ$ > 600 - 800 GeV for operators with right-handed $τ$ leptons using the LHC run 1 data.
description: 22 pages, 2 figures, changed from general effective four fermion interactions to gauge invariant operators, matches published version
Neural crest requires Impdh 2 for development of the enteric nervous system, great vessels, and craniofacial skeleton
Creators: name: Zimmermann, Albert G.
name: Lake, Jonathan I.
name: Heuckeroth, Robert O.
name: Avetisyan, Marina
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Mutations that impair the proliferation of enteric neural crest-derived cells (ENCDC) cause Hirschsprung disease, a potentially lethal birth defect where the enteric nervous system (ENS) is absent from distal bowel. Inosine 5′ monophosphate dehydrogenase (IMPDH) activity is essential for de novo GMP synthesis, and chemical inhibition of IMPDH induces Hirschsprung disease-like pathology in mouse models by reducing ENCDC proliferation. Two IMPDH isoforms are ubiquitously expressed in the embryo, but only IMPDH2 is required for life. To further understand the role of IMPDH2 in ENS and neural crest development, we characterized a conditional Impdh2 mutant mouse. Deletion of Impdh2 in the early neural crest using the Wnt1-Cre transgene produced defects in multiple neural crest derivatives including highly penetrant intestinal aganglionosis, agenesis of the craniofacial skeleton, and cardiac outflow tract and great vessel malformations. Analysis using a Rosa26 reporter mouse suggested that some or all of the remaining ENS in Impdh2 conditional-knockout animals was derived from cells that escaped Wnt1-Cre mediated DNA recombination. These data suggest that IMPDH2 mediated guanine nucleotide synthesis is essential for normal development of the ENS and other neural crest derivatives.
title: Effectiveness of combinated mechanic trombectomy and angioplasty in the treatment of Thrombosed Arteriovenous Grafts (AVg) for hemodialysis. Our Experience
Creators: name: Paúl Ferrer, Laura
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Grafts
subject: Embolism / Thrombosis
subject: Recanalisation
subject: Angioplasty
subject: Thrombolysis
subject: Percutaneous
subject: Catheter venography
subject: Veins / Vena cava
subject: Vascular
subject: Interventional vascular

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Thrombosis is the main cause of AVFg disfunction. Percutaneous thrombolysis has become an accepted treatment of thrombosed haemodialysis. Nowadaysthere are several devices developed for mechanical thrombolysis that allow to macerate the clot using...
Studying the impact of electron bunch characteristics on plasma wakefield performance using particle-in-cell simulations
Creators: name: Wrobel, Nico
Publisher: name: Rodare
Year: 2023
Subjects: PWFA, PIConGPU, Plasma Accelerator

description: The submitted version of my bachelor thesis. Abstract The accessibility of plasma-based accelerators was greatly expanded by the realization of laser wakefield accelerator (LWFA)-driven plasma wakefield accelerators (PWFA). This development speeds up research on PWFA significantly. In this thesis, 3D particle-in-cell-simulations were used to analyze driver parameters for a PWFA to achieve maximal energy gain for a hypothetical witness beam. Only small increases in witness energy were found when drivers with high kinetic energy were compared. In contrast, great witness energy increases result when the divergence of the driver gets reduced. The transformation of a driver in plasma is analyzed, and the influence of the wakefield on it is discussed. Additionally, evidence for non-constant peak energy is presented, with energy losses in the MeV scale independent from driver characteristics. This could require adjustments to the charge reconstruction of the LWFA bunch after the PWFA stage.
Molecular line formation in the extremely metal-poor star BD+44 493
Creators: name: Aoki, Wako
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Molecular absorption lines of OH (99 lines) and CH (105 lines) are measured for the carbon-enhanced metal-poor star BD+44 493 with [Fe/H]=-3.8. The abundances of oxygen and carbon determined from individual lines based on an 1D-LTE analysis exhibit significant dependence on excitation potentials of the lines; d log e/d chi ~ -0.15 - -0.2 dex/eV, where e and chi are elemental abundances from individual spectral lines and their excitation potentials, respectively. The dependence is not explained by the uncertainties of stellar parameters, but suggests that the atmosphere of this object possesses a cool layer that is not reproduced by the 1D model atmosphere. This result agrees with the predictions by 3D model calculations. Although absorption lines of neutral iron exhibit similar trend, it is much weaker than found in molecular lines and that predicted by 3D LTE models.
description: 7 figures, 2 tables, to appear in ApJ
title: Ultrasound elastography; can replace transrectal prostatic biopsy in detection of prostatic cancer
Creators: name: Abd-Elfattah, Amr
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Oncology
subject: Ultrasound
subject: Diagnostic procedure
subject: Multidisciplinary cancer care

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To detect the impact of ultrasound elastography in diagnosis of prostatic cancer, and to evaluate its capability in differentiating benign from malignant...
RNA helicase Belle/DDX3 regulates transgene expression in  Drosophila
Creators: name: Xie, Gengqiang
name: Lo, Pang-Kuo
name: Klusza, Stephen
name: Deng, Wu-Min
name: Palmer, William H.
name: Poulton, John S.
name: Leake, Nicholas
name: Vera, Daniel
name: Huang, Yi-Chun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Belle (Bel), the Drosophila homolog of the yeast DEAD-box RNA helicase DED1 and human DDX3, has been shown to be required for oogenesis and female fertility. Here we report a novel role of Bel in regulating the expression of transgenes. Abrogation of Bel by mutations or RNAi induces silencing of a variety of P-element-derived transgenes. This silencing effect depends on downregulation of their RNA levels. Our genetic studies have revealed that the RNA helicase Spindle-E (Spn-E), a nuage RNA helicase that plays a crucial role in regulating RNA processing and PIWI-interacting RNA (piRNA) biogenesis in germline cells, is required for loss-of-bel-induced transgene silencing. Conversely, Bel abrogation alleviates the nuage-protein mislocalization phenotype in spn-E mutants, suggesting a competitive relationship between these two RNA helicases. Additionally, disruption of the chromatin remodeling factor Mod(mdg4) or the microRNA biogenesis enzyme Dcr-1 also rescued the transgene-silencing phenotypes in bel mutants, suggesting the involvement of chromatin remodeling and microRNA biogenesis in loss-of-bel-induced transgene silencing. Finally we showed that genetic inhibition of Bel function led to the de novo generation of piRNAs from the transgene region inserted in the genome, suggesting a potential piRNA-dependent mechanism that may mediate transgene silencing as Bel function is inhibited. Our findings have demonstrated a novel involvement of Bel in regulating transgene expression and its loss triggers a transgene silencing mechanism mediated by protein regulators implicated in RNA processing, piRNA biogenesis, chromatin remodeling and the microRNA pathway.
title: CT coronary angiogram (CTCA) oral beta-blocker premedication: effect of medication dose on heart rate and blood pressure
Creators: name: Wong, Cheuk Kei Kathy
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Cardiac
subject: CT
subject: Education
subject: Artifacts

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To evaluate the effect of single or additional doses of oral beta-blocker protocol in heart rate control and blood...
Rust Vulnerability Analysis and Maturity Challenges
Creators: name: Wassermann, Garret
name: Svoboda, David
Publisher: name: Carnegie Mellon University
Year: 2023
Subjects: subject: 80309 Software Engineering
subject: FOS: Computer and information sciences

description: While the memory safety and security features of the Rust programming language can be effective in many situations, Rust’s compiler is very particular on what constitutes good software design practices. Whenever design assumptions disagree with real-world data and assumptions, there is the possibility of security vulnerabilities–and malicious software that can take advantage of those vulnerabilities. In this post, we will focus on users of Rust programs, rather than Rust developers. We will explore some tools for understanding vulnerabilities whether the original source code is available or not. These tools are important for understanding malicious software where source code is often unavailable, as well as commenting on possible directions in which tools and automated code analysis can improve. We also comment on the maturity of the Rust software ecosystem as a whole and how that might impact future security responses, including via the coordinated vulnerability disclosure methods advocated by the SEI’s CERT Coordination Center (CERT/CC). This post is the second in a series exploring the Rust programming language. The first post explored security issues with Rust.
title: MRI in osteoregeneration process assessment of children long tubular bones fractures
Creators: name: Tarasenko, Lyubov
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Bones
subject: Paediatric
subject: Musculoskeletal joint
subject: MR
subject: Imaging sequences
subject: Trauma

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The goal is to examine the role of MRI in the healing process in fractures of long tubular bones in children, comparing the dynamics of the IR-signal with the stage of reparative osteogenesis and the expression of the development of granulation...
Towards integrated urban agriculture systems: economic and valuation aspects
Creators: name: Miccoli, Saverio
name: Finucci, Fabrizio
name: Murro, Rocco
Publisher: name: Aestimum
Year: 2016

description: The Paper defines an integrated urban agriculture system (A-URBIS), outlining the complications associated with its launching and implementation, and a methodological guidelines for the valuation of an A-URBIS, taking into account the inclusive and qualitative impacts on the community. Finally the Paper proposes a Direct Deliberative Monetary Valuation procedure which derives from the combination of a participatory deliberative process, which is necessary to develop instruments of direct democracy, and Stated Preference Techniques, which are essential to capture the value related to inclusive use.
description: Aestimum, Atti del XLIII Incontro di Studio (Verona)
How to assess the compensations for home relocation: the case of the Malpensa airport
Creators: name: Oppio, Alessandra
name: Mattia, Sergio
Publisher: name: Aestimum
Year: 2016

description: The development of the Malpensa airport into a Hub for the Central and South Europe has produced on one side relevant economic impacts, on the other one considerable environmental problems, due to the noise and atmospheric pollution, especially for the inhabitants who live within a distance of 400 meters from the airport. In the face of this difficult situation, the Lombardy Region has endorsed an agreement for relocating and compensating households affected by the environmental negative externalities. In this context the paper introduces the appraisal procedure used for estimating compensations and discusses the results, mostly in terms of deviation from the expected values and effectiveness of the model.
description: Aestimum, Atti del XLIII Incontro di Studio (Verona)
The stress statistics of the first pop-in or intermittent plastic event in cyrstal plasticity
Creators: name: Derlet, Peter
name: Maaß, Robert
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The first plastic event occurring in discrete intermittent plasticity, as for example a pop-in seen in nano-indentation, is evaluated with extreme value statistics. It is found that when the same deformation is repeated many times, the average of the stress at this first event is related to the deforming volume via an exponentially truncated power-law. The present work demonstrates this trend and the expected Weibull fluctuation around it. The statistical formalism is shown to apply to the nano-indentation data of Morris {\em et al}, Phys. Rev. Lett. 106, 165502 (2011), as well as to dislocation dynamics simulations, which suggests a general phenomenon is at play. The truncated power law is found to uniquely determine an underlying critical stress master probability density function in terms of the Lambert-W function and the density of discrete plastic events available to the crystal. Thus the developed procedure allows for a quantitative characterization of a bulk material's initial microstructure via a deformation experiment that probes discrete intermittent plasticity.
description: 25 pages, 5 figures, under review
The SWI/SNF BAF-A complex is essential for neural crest development
Creators: name: Magnuson, Terry
name: Chandler, Ronald L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Growing evidence indicates that chromatin remodeler mutations underlie the pathogenesis of human neurocristopathies or disorders that affect neural crest cells (NCCs). However, causal relationships among chromatin remodeler subunit mutations and NCC defects remain poorly understood. Here we show that homozygous loss of ARID1A-containing, SWI/SNF chromatin remodeling complexes (BAF-A) in NCCs results in embryonic lethality in mice, with mutant embryos succumbing to heart defects. Strikingly, monoallelic loss of ARID1A in NCCs led to craniofacial defects in adult mice, including shortened snouts and low set ears, and these defects were more pronounced following homozygous loss of ARID1A, with the ventral cranial bones being greatly reduced in size. Early NCC specification and expression of the BRG1 NCC target gene, PLEXINA2, occurred normally in the absence of ARID1A. Nonetheless, mutant embryos displayed incomplete conotruncal septation of the cardiac outflow tract and defects in the posterior pharyngeal arteries, culminating in persistent truncus arteriosus and agenesis of the ductus arteriosus. Consistent with this, migrating cardiac NCCs underwent apoptosis within the circumpharyngeal ridge. Our data support the notion that multiple, distinct chromatin remodeling complexes govern genetically separable events in NCC development and highlight a potential pathogenic role for NCCs in the human BAF complex disorder, Coffin-Siris Syndrome.
Report on the ETHNA System Implementation Analysis - ETHNA System Project – Deliverable 5.4
Creators: name: Alves, Elsa
Publisher: name: Zenodo
Year: 2022
Subjects: ETHNA System
RRI
Ethical Governance
Open Access
Research Integrity
Gender
Research centres
Higher Education
Research Funding

description: This report is an account and short analysis of the status of the ETHNA System pilots, based on the two participatory evaluation workshops with the ETHNA System implementing partners held online on 15 and 16 September 2022. The main aim of this report is to structure quotes by the partners as a supplement to the further data gathered in the evaluative activities of tasks 4.4 and 6.1. The overall objective of task 4.4 is to create a blueprint for institutional change to bring to life an effective RRI governance. The objective of T6.1 is to evaluate the implementation of the ETHNA System, critically examining the findings and outcomes from the WP5 implementation process.
 In particular, this report is focused on the progress update following the initial implementation scope1, as well as indicates some early positive impact, institutional changes, and constraints. The implementers have followed the ETHNA guide for the system implementation, issued as D4.2: A Guide to the Ethical Governance of RRI in Innovation and Research in Research Performing Organisations and Research Funding Organisations2. For a detailed account on the challenges faced by the pilots, refer to D5.5: Report collecting the difficulties found in the implementation processes. Furthermore, this report also indicates some reflections regarding the ETHNA legacy and the outlook for its future at the implementing organisations.
A tribute to Giovanni Anania: Scholar, Mentor, Friend
Creators: name:  ,
Publisher: name: Bio-based and Applied Economics
Year: 2015

description: This section collects several contributions intended to offer a tribute to Giovanni Anania. Giovanni suddenly and unexpectedly passed away on 15 July 2015. This section is based on the contributions to the special session chaired by Jo Swinnen - held at the 29th International Conference of Agricultural Economics, Milan, 9-14 August 2015 - to honor the memory and contribution of Giovanni Anania.
description: Bio-based and Applied Economics, Vol 4 No 3 (2015): Innovation, productivity and growth: towards sustainable agri-food production
Research and innovation in agriculture: beyond productivity?
Creators: name: Viaggi, Davide
Publisher: name: Bio-based and Applied Economics
Year: 2015

description: Studies on the effects of research and innovation in agriculture have been largely characterised by efforts to make a connection between expenditure and productivity. A number of issues have challenged the ability of productivity to measure the effects of research, namely, in recent years, increasing efforts towards improving the environmental performance of the farming sector. Besides environmental concerns, however, a number of recent concepts have emerged that are shaping the current research and policy agenda and which could result in a revision of the productivity concepts used to evaluate research impacts. The objective of this paper is to discuss these issues and their implications for studies on the impact of research and innovation. We address, in particular, the following issues: a) the development of the of bioeconomy and related concepts such as the circular economy, resource efficiency and bio-refinery; b) the connection with entrepreneurship and eco-innovation; c) changing tools in research assessment, in particular the widespread use of Life Cycle Assessment (LCA); and d) the evolving concepts of sustainability and ecosystem services. We argue that while the traditional notion of productivity, intended as output/input ratio, maintains (and may be strengthens) its role on the aggregate, a more analytical interpretation of the pathways towards research impacts is needed, as well as a broadened view of productivity and its determinants.
description: Bio-based and Applied Economics, Vol 4 No 3 (2015): Innovation, productivity and growth: towards sustainable agri-food production
Vascular development in the vertebrate pancreas
Creators: name: Azizoglu, D. Berfin
name: Magenheim, Judith
name: Cleaver, Ondine
name: Villasenor, Alethia
name: Barry, David M.
name: Lee, Simon
name: Marty-Santos, Leilani
name: Dor, Yuval
name: Fu, Stephen
name: Chong, Diana C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The vertebrate pancreas is comprised of a highly branched tubular epithelium, which is intimately associated with an extensive and specialized vasculature. While we know a great deal about basic vascular anatomy of the adult pancreas, as well as islet capillaries, surprisingly little is known about the ontogeny of its blood vessels. Here, we analyze development of the pancreatic vasculature in the mouse embryo. We show that pancreatic epithelial branches intercalate with the fine capillary plexus of the surrounding pancreatic mesenchyme. Endothelial cells (ECs) within this mesenchyme are heterogeneous from the onset of organogenesis. Pancreatic arteries take shape before veins, in a manner analogous to early embryonic vessels. The main central artery forms during mid-gestation, as a result of vessel coalescence and remodeling of a vascular plexus. In addition, we show that vessels in the forming pancreas display a predictable architecture that is dependent on VEGF signaling. Over-expression of VEGF disrupts vascular patterning and arteriovenous differentiation within the developing pancreas. This study constitutes a first-time cellular and molecular characterization of pancreatic blood vessels, as they coordinately grow along with the pancreatic epithelium.
Multi-scale structure and topological anomaly detection via a new network statistic: The onion decomposition
Creators: name: Hébert-Dufresne, Laurent
name: Grochow, Joshua A.
name: Allard, Antoine
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Discrete Mathematics (cs.DM)
subject: Social and Information Networks (cs.SI)
subject: Combinatorics (math.CO)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: We introduce a new network statistic that measures diverse structural properties at the micro-, meso-, and macroscopic scales, while still being easy to compute and easy to interpret at a glance. Our statistic, the onion spectrum, is based on the onion decomposition, which refines the k-core decomposition, a standard network fingerprinting method. The onion spectrum is exactly as easy to compute as the k-cores: It is based on the stages at which each vertex gets removed from a graph in the standard algorithm for computing the k-cores. But the onion spectrum reveals much more information about a network, and at multiple scales; for example, it can be used to quantify node heterogeneity, degree correlations, centrality, and tree- or lattice-likeness of the whole network as well as of each k-core. Furthermore, unlike the k-core decomposition, the combined degree-onion spectrum immediately gives a clear local picture of the network around each node which allows the detection of interesting subgraphs whose topological structure differs from the global network organization. This local description can also be leveraged to easily generate samples from the ensemble of networks with a given joint degree-onion distribution. We demonstrate the utility of the onion spectrum for understanding both static and dynamic properties on several standard graph models and on many real-world networks.
description: 8 pages manuscript, 6 figures
Application of covariant analytic mechanics with differential forms to gravity with Dirac field
Creators: name: Nakajima, Satoshi
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We apply the covariant analytic mechanics with the differential forms to the Dirac field and the gravity with the Dirac field. The covariant analytic mechanics treats space and time on an equal footing regarding the differential forms as the basic variables. A significant feature of the covariant analytic mechanics is that the canonical equations, in addition to the Euler-Lagrange equation, are not only manifestly general coordinate covariant but also gauge covariant. Combining our study and the previous works (the scalar field, the abelian and non-abelian gauge fields and the gravity without the Dirac field), the applicability of the covariant analytic mechanics is checked for all fundamental fields. We study both the first and second order formalism of the gravitational field coupled with matters including the Dirac field. It is suggested that gravitation theories including higher order curvatures cannot be treated by the second order formalism in the covariant analytic mechanics.
description: 14 pages, no figure
Electronic tuneability of a structurally rigid surface intermetallic and Kondo lattice: CePt$_5$ / Pt(111)
Creators: name: Praetorius, C.
name: Zinner, M.
name: Köhl, A.
name: Kießling, H.
name: Brück, S.
name: Muenzing, B.
name: Kamp, M.
name: Kachel, T.
name: Choueikani, F.
name: Ohresser, P.
name: Wilhelm, F.
name: Rogalev, A.
name: Fauth, K.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We present an extensive study of structure, composition, electronic and magnetic properties of Ce--Pt surface intermetallic phases on Pt(111) as a function of their thickness. The sequence of structural phases appearing in low energy electron diffraction (LEED) may invariably be attributed to a single underlying intermetallic atomic lattice. Findings from both microscopic and spectroscopic methods, respectively, prove compatible with CePt$_5$ formation when their characteristic probing depth is adequately taken into account. The intermetallic film thickness serves as an effective tuning parameter which brings about characteristic variations of the Cerium valence and related properties. Soft x-ray absorption (XAS) and magnetic circular dichroism (XMCD) prove well suited to trace the changing Ce valence and to assess relevant aspects of Kondo physics in the CePt$_5$ surface intermetallic. We find characteristic Kondo scales of the order of 10$^2$ K and evidence for considerable magnetic Kondo screening of the local Ce $4f$ moments. CePt$_5$/Pt(111) and related systems therefore appear to be promising candidates for further studies of low-dimensional Kondo lattices at surfaces.
description: 14 pages, 11 figures
Expanding the genetic toolkit in  Xenopus : Approaches and opportunities for human disease modeling
Creators: name: Conlon, Frank
name: Horb, Marko E.
name: Furlow, J. David
name: Tandon, Panna
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: The amphibian model Xenopus, has been used extensively over the past century to study multiple aspects of cell and developmental biology. Xenopus offers advantages of a non-mammalian system, including high fecundity, external development, and simple housing requirements, with additional advantages of large embryos, highly conserved developmental processes, and close evolutionary relationship to higher vertebrates. There are two main species of Xenopus used in biomedical research, Xenopus laevis and Xenopus tropicalis; the common perception is that both species are excellent models for embryological and cell biological studies, but only Xenopus tropicalis is useful as a genetic model. The recent completion of the Xenopus laevis genome sequence combined with implementation of genome editing tools, such as TALENs (transcription activator-like effector nucleases) and CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR associated nucleases), greatly facilitates the use of both Xenopus laevis and Xenopus tropicalis for understanding gene function in development and disease. In this paper, we review recent advances made in Xenopus laevis and Xenopus tropicalis with TALENs and CRISPR-Cas and discuss the various approaches that have been used to generate knockout and knock-in animals in both species. These advances show that both Xenopus species are useful for genetic approaches and in particular counters the notion that Xenopus laevis is not amenable to genetic manipulations.
The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation
Creators: name: Dorr, Kerry M.
name: Cristea, Ileana M.
name: Conlon, Frank L.
name: Yang, Xinan Holly
name: Temple, Brenda
name: Moskowitz, Ivan P.
name: Waldron, Lauren
name: Wilczewski, Caralynn M.
name: Greco, Todd M.
name: Davis, Ian J.
name: Kweon, Junghun
name: Steimle, Jeffrey D.
name: Gomez, Nicholas C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Human mutations in the cardiac transcription factor gene TBX5 cause Congenital Heart Disease (CHD), however the underlying mechanism is unknown. We report characterization of the endogenous TBX5 cardiac interactome and demonstrate that TBX5, long considered a transcriptional activator, interacts biochemically and genetically with the Nucleosome Remodeling and Deacetylase (NuRD) repressor complex. Incompatible gene programs are repressed by TBX5 in the developing heart. CHD missense mutations that disrupt the TBX5-NuRD interaction cause depression of a subset of repressed genes. Furthermore, the TBX5-NuRD interaction is required for heart development. Phylogenetic analysis showed that the TBX5-NuRD interaction domain evolved during early diversification of vertebrates, simultaneous with the evolution of cardiac septation. Collectively, this work defines a TBX5-NuRD interaction essential to cardiac development and the evolution of the mammalian heart, and when altered may contribute to human CHD.
Diffraction limited focusing and routing of gap plasmons by a metal-dielectric-metal lens
Creators: name: Dennis, Brian S.
name: Czaplewski, David A.
name: Haftel, Michael I.
name: Lopez, Daniel
name: Blumberg, Girsh
name: Aksyuk, Vladimir
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Passive optical elements can play key roles in photonic applications such as plasmonic integrated circuits. Here we experimentally demonstrate passive gap-plasmon focusing and routing in two-dimensions. This is accomplished using a high numerical-aperture metal-dielectric-metal lens incorporated into a planar-waveguide device. Fabrication via metal sputtering, oxide deposition, electron- and focused-ion- beam lithography, and argon ion-milling is reported on in detail. Diffraction-limited focusing is optically characterized by sampling out-coupled light with a microscope. The measured focal distance and full-width-half-maximum spot size agree well with the calculated lens performance. The surface plasmon polariton propagation length is measured by sampling light from multiple out-coupler slits.
Nonclassicality versus entanglement in a noncommutative space
Creators: name: Dey, Sanjib
name: Fring, Andreas
name: Hussin, Véronique
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: In a setting of noncommutative space with minimal length we confirm the general assertion that the more nonclassical an input state for a beam splitter is, the more entangled its output state becomes. By analysing various nonclassical properties we find that the odd Schrödinger cat states are more nonclassical than the even Schrödinger cat states, hence producing more entanglement, which in turn are more nonclassical than coherent states. Both the nonclassicality and the entanglement can be enhanced by increasing the noncommutativity of the underlying space. In addition we find as a by-product some rare explicit minimum uncertainty quadrature and number squeezed states, i.e. ideal squeezed states.
description: 15 pages, 7 figures
Implications of newborn amygdala connectivity for fear and cognitive development at 6-months-of-age
Creators: name: Styner, Martin
name: Fair, Damien A.
name: Graham, Alice M.
name: Entringer, Sonja
name: Gilmore, John H.
name: Buss, Claudia
name: Rudolph, Marc D.
name: Wadhwa, Pathik D.
name: Demeter, Damion V.
name: Rasmussen, Jerod M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The first year of life is an important period for emergence of fear in humans. While animal models have revealed developmental changes in amygdala circuitry accompanying emerging fear, human neural systems involved in early fear development remain poorly understood. To increase understanding of the neural foundations of human fear, it is important to consider parallel cognitive development, which may modulate associations between typical development of early fear and subsequent risk for fear-related psychopathology. We, therefore, examined amygdala functional connectivity with rs-fcMRI in 48 neonates (M=3.65 weeks, SD=1.72), and measured fear and cognitive development at 6-months-of-age. Stronger, positive neonatal amygdala connectivity to several regions, including bilateral anterior insula and ventral striatum, was prospectively associated with higher fear at 6-months. Stronger amygdala connectivity to ventral anterior cingulate/anterior medial prefrontal cortex predicted a specific phenotype of higher fear combined with more advanced cognitive development. Overall, findings demonstrate unique profiles of neonatal amygdala functional connectivity related to emerging fear and cognitive development, which may have implications for normative and pathological fear in later years. Consideration of infant fear in the context of cognitive development will likely contribute to a more nuanced understanding of fear, its neural bases, and its implications for future mental health.
Light-matter micro-macro entanglement
Creators: name: Tiranov, Alexey
name: Lavoie, Jonathan
name: Strassmann, Peter C.
name: Sangouard, Nicolas
name: Afzelius, Mikael
name: Bussières, Félix
name: Gisin, Nicolas
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum mechanics predicts microscopic phenomena with undeniable success. Nevertheless, current theoretical and experimental efforts still do not yield conclusive evidence that there is, or not, a fundamental limitation on the possibility to observe quantum phenomena at the macroscopic scale. This question prompted several experimental efforts producing quantum superpositions of large quantum states in light or matter. Here we report on the observation of entanglement between a single photon and an atomic ensemble. The certified entanglement stems from a light-matter micro-macro entangled state that involves the superposition of two macroscopically distinguishable solid-state components composed of several tens of atomic excitations. Our approach leverages from quantum memory techniques and could be used in other systems to expand the size of quantum superpositions in matter.
Working memory filtering continues to develop into late adolescence
Creators: name: McLaughlin, Katie A.
name: Finn, Amy S.
name: Peverill, Matthew
name: Sheridan, Margaret A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: While most measures of working memory (WM) performance have been shown to plateau by mid-adolescence and developmental changes in fronto-parietal regions supporting WM encoding and maintenance have been well characterized, little is known about developmental variation in WM filtering. We investigated the possibility that the neural underpinnings of filtering in WM reach maturity later in life than WM function without filtering. Using a cued WM filtering task (McNab and Klingberg, 2008), we investigated neural activity during WM filtering in a sample of 64 adults and adolescents. Regardless of age, increases in WM activity with load were concentrated in the expected fronto-parietal network. For adults, but not adolescents, recruitment of the basal ganglia during presentation of a filtering cue was associated with neural and behavioral indices of successful filtering, suggesting that WM filtering and related basal ganglia function may still be maturing throughout adolescence and into adulthood.
Report on the Developed and Validated Underwater Thematic Services #1
Creators: name: Quintana, Josep
name: Campos, Ricard
name: Nomikou, Paraskevi
name: Karantzalos, Konstantinos
name: Baika, Kalliopi
name: Anbar, Jafar
name: Sourisseau, Jean-Christophe
name: Lampridou, Danai
name: Ntouskos, Makis
name: Tsironis, Vasilios
name: Mertikas, Panagiotis
name: Foskolos, Nikolaos
name: Wintersteller, Paul
Publisher: name: Zenodo
Year: 2020
Subjects: EOSC
Services
Cloud Computing
Underwater Research

description: This document reports on the 1st release of the underwater services and the software underlying each service. This report, NEANIAS deliverable 2.4, is published right after the first thematic underwater services release, i.e., deliverable D2.3 and the initial validation phase based on mostly internal end-users.
 The U1 [UW_BAT] “Bathymetry mapping from acoustic data service implementation” provides an advanced user-friendly, cloud-based version of the popular MB-System software, for processing bathymetric data through Jupyter Notebooks. The U2 [UW_MOS] service “Seafloor Mosaicking from Optical Data” delivers 2D/3D mosaics produced by a set of images and navigational data. The expected output is achieved by a processing pipeline based on in-house solutions and open-source libraries. Finally, the U3 [UW_MAP] service “Seabed Classification from Multispectral, Multibeam Data” provides an easy-to-use, cloud-based solution incorporating machine learning frameworks in order to identify different seabed classes.
 For each released service a point-of-access is provided, as well as the relevant documentation, which is organized under NEANIAS docs service at https://docs.neanias.eu/en/latest.
 Services reported here have gone through the first release round, most services have been integrated to NEANIAS authentication system service, the documentation workflow, and integrated with GARR infrastructure services. As expected, this first services milestone uncovered some gaps in the services deployment stack and integration with other core and delivery services will be addressed for the next milestones and releases.
Effects of prior testing lasting a full year in NCANDA adolescents: Contributions from age, sex, socioeconomic status, ethnicity, site, family history of alcohol or drug abuse, and baseline performance
Creators: name: Pfefferbaum, Adolf
name: Prouty, Devin
name: Hooper, Stephen R.
name: Tapert, Susan F.
name: Brown, Sandra A.
name: De Bellis, Michael D.
name: Pohl, Kilian M.
name: Clark, Duncan B.
name: Baker, Fiona C.
name: Nichols, B. Nolan
name: Nagel, Bonnie J.
name: Sullivan, Edith V.
name: Fama, Rosemary
name: Brumback, Ty
name: Chu, Weiwei
name: Kwon, Dongjin
name: Cummins, Kevin
name: Colrain, Ian M.
name: Chung, Tammy
name: Thompson, Wesley K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Author(s): Sullivan, EV; Brumback, T; Tapert, SF; Prouty, D; Fama, R; Thompson, WK; Brown, SA; Cummins, K; Colrain, IM; Baker, FC; Clark, DB; Chung, T; De Bellis, MD; Hooper, SR; Nagel, BJ; Nichols, BN; Chu, W; Kwon, D; Pohl, KM; Pfefferbaum, A | Abstract: © 2017 The Authors Longitudinal study provides a robust method for tracking developmental trajectories. Yet inherent problems of retesting pose challenges in distinguishing biological developmental change from prior testing experience. We examined factors potentially influencing change scores on 16 neuropsychological test composites over 1 year in 568 adolescents in the National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) project. The twice-minus-once-tested method revealed that performance gain was mainly attributable to testing experience (practice) with little contribution from predicted developmental effects. Group mean practice slopes for 13 composites indicated that 60% to ∼100% variance was attributable to test experience; General Ability accuracy showed the least practice effect (29%). Lower baseline performance, especially in younger participants, was a strong predictor of greater gain. Contributions from age, sex, ethnicity, examination site, socioeconomic status, or family history of alcohol/substance abuse were nil to small, even where statistically significant. Recognizing that a substantial proportion of change in longitudinal testing, even over 1-year, is attributable to testing experience indicates caution against assuming that performance gain observed during periods of maturation necessarily reflects development. Estimates of testing experience, a form of learning, may be a relevant metric for detecting interim influences, such as alcohol use or traumatic episodes, on behavior.
The deconfining phase transition of SO(N) gauge theories in 2+1 dimensions
Creators: name: Lau, Richard
name: Teper, Michael
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We calculate the deconfining temperature of SO(N) gauge theories in 2+1 dimensions, and determine the order of the phase transition as a function of N, for various values of N in the range [4,16]. We do so by extrapolating our lattice results to the infinite volume limit, and then to the continuum limit, for each value of N. We then extrapolate to the N=infinity limit and observe that the SO(N) and SU(N) deconfining temperatures agree in that limit. We find that the the deconfining temperatures of all the SO(N) gauge theories appear to follow a single smooth function of N, despite the lack of a non-trivial centre for odd N. We also compare the deconfining temperatures of SO(6) with SU(4), and of SO(4) with SU(2)xSU(2), motivated by the fact that these pairs of gauge theories share the same Lie algebras.
description: 52 pages, 20 figures. Some introductory material removed. Improved discussion of odd N, the centre and confinement
Anomalous metallic state in quasi-two-dimensional BaNiS$_{2}$
Creators: name: Santos-Cottin, David
name: Gauzzi, Andrea
name: Verseils, Marine
name: Baptiste, Benoit
name: Feve, Gwendal
name: Freulon, Vincent
name: Placais, Bernard
name: Casula, Michele
name: Klein, Yannick
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We report on a systematic study of the thermodynamic, electronic and charge transport properties of high-quality single crystals of BaNiS$_2$, the metallic end-member of the quasi-twodimensional BaCo$_{1-x}$Ni$_x$S$_2$ system characterized by a metal-insulator transition at $x_{cr}=0.22$. Our analysis of magnetoresistivity and specific heat data consistently suggests a picture of compensated semimetal with two hole- and one electron-bands, where electron-phonon scattering dominates charge transport and the minority holes exhibit, below $\sim$100 K, a very large mobility, $μ_h\sim$ 15000 cm$^2$V$^{-1}$s$^{-1}$, which is explained by a Dirac-like band. Evidence of unconventional metallic properties is given by an intriguing crossover of the resistivity from a Bloch-Grüneisen regime to a linear$-T$ regime occurring at 2 K and by a strong linear term in the paramagnetic susceptibility above 100 K. We discuss the possibility that these anomalies reflect a departure from conventional Fermi-liquid properties in presence of short-range AF fluctuations and of a large Hund coupling.
description: 21 pages 9 figures (colors)
T1.1 Portuguese Spatial Planning Instruments for assessing Transformative Change
Creators: name: Batista e Silva, Jorge
name: David, Nuno
name: Loupa Ramos, Isabel
name: Hoyos Rojas, Lina
Publisher: name: Zenodo
Year: 2023

description: List of legal documents and spatial planning from different scales based on the example of Setúbal Municipality.