cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
MD investigation on the differences in the dynamic interactions between the specific ligand azamulin and two CYP3A isoforms, 3A4 and 3A5
Creators: name: Liu, Shuhui
name: Jing, Tao
name: Jia, Ran
name: Zhang, Ji-Long
name: Bai, Fu-Quan
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biophysics
Biochemistry
Physical Sciences not elsewhere classified
Molecular Biology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified

description: The unmarked potential drug molecule azamulin has been found to be a specific inhibitor of CYP3A4 and CYP3A5 in recent years, but this molecule also shows different binding ability and affinity to the two CYP3A isoforms. In order to explore the microscopic mechanism, conventional molecular dynamics (MD) simulation methods were performed to study the dynamic interactions between two isoforms and azamulin. The simulation results show that the binding of the ligand leads to different structural properties of two CYP3A proteins. First of all, compared with apo-CYP3A4, the binding of the ligand azamulin can lead to changes in the structural flexibility of CYP3A4, i.e., holo-CYP3A4 is more flexible than apo-CYP3A4. The structural changes of CYP3A5 are just the opposite. The ligand binding increases the rigidity of CYP3A5. Furthermore, the representative structures of the production phase in the MD simulation were in details analyzed to obtain the microscopic interactions between the ligand azamulin and two CYP3A isoforms at the atomic level. It is speculated that the difference of composition and interaction of the active sites is the fundamental cause of the change of structural properties of the two proteins.
title: ÐÐ¾Ð¿Ð¾Ð»Ð½Ð¸ÑÐµÐ»ÑÐ½ÑÐµ Ð³Ð»Ð°Ð²Ñ ÑÐµÐ¾ÑÐµÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÐ¸Ð·Ð¸ÐºÐ¸. ÐÐµÐ¹Ð²Ð»ÐµÑÑ
title: ÑÑÐµÐ±Ð½Ð¾Ðµ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ðµ
titleType: Subtitle
Creators: name: ÐÐ¾Ð¶Ð¾ÐºÐ¸Ð½, Ð¡ÐµÑÐ³ÐµÐ¹
name: ÐÑÐºÐ¾Ð², Ð¡ÐµÑÐ³ÐµÐ¹
Publisher: name: ÐÐ·Ð´-Ð²Ð¾ ÐÐ¾Ð»Ð¸ÑÐµÑÐ½. ÑÐ½-ÑÐ°
Year: 2007
Subjects: ÐÐ°ÑÐµÐ¼Ð°ÑÐ¸ÑÐµÑÐºÐ°Ñ ÑÐ¸Ð·Ð¸ÐºÐ°
ÐÐµÐ¹Ð²Ð»ÐµÑÐ¾Ð² ÑÐµÐ¾ÑÐ¸Ñ

description: ÐÐ¾ÑÐ¾Ð±Ð¸Ðµ Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÑÐµÑ ÑÐ¾Ð±Ð¾Ð¹ Ð²Ð²Ð¾Ð´Ð½ÑÐ¹ ÐºÑÑÑ Ð² ÑÐµÐ¾ÑÐ¸Ñ Ð²ÐµÐ¹Ð²Ð»ÐµÑÐ¾Ð², ÑÑÐµÑÐ° Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ ÐºÐ¾ÑÐ¾ÑÐ¾Ð¹ Ð² Ð½Ð°ÑÑÐ¾ÑÑÐµÐµ Ð²ÑÐµÐ¼Ñ Ð±ÑÑÑÑÐ¾ ÑÐ°ÑÑÐ¸ÑÑÐµÑÑÑ Ð¸ Ð¾ÑÐ²Ð°ÑÑÐ²Ð°ÐµÑ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÐµ Ð¾Ð±Ð»Ð°ÑÑÐ¸ Ð¼Ð°ÑÐµÐ¼Ð°ÑÐ¸ÐºÐ¸, ÑÐ¸Ð·Ð¸ÐºÐ¸, Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸Ð¸, Ð¼ÐµÐ´Ð¸ÑÐ¸Ð½Ñ. Ð Ð¿Ð¾ÑÐ¾Ð±Ð¸Ð¸ Ð¸Ð·Ð»Ð¾Ð¶ÐµÐ½Ð¸Ðµ ÑÐµÐ¾ÑÐ¸Ð¸ Ð²ÐµÐ¹Ð²Ð»ÐµÑÐ¾Ð² Ð²ÐµÐ´ÐµÑÑÑ ÑÐ¾Ð²Ð¼ÐµÑÑÐ½Ð¾ Ñ ÑÐ°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ð¸ÐµÐ¼ Ð¿ÑÐµÐ¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¤ÑÑÑÐµ.
Ð£ÑÐµÐ±Ð½ÑÐ¹ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð» Ð¿Ð¾ÑÐ¾Ð±Ð¸Ñ ÑÐ°ÑÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½ Ð¿Ð¾ ÑÑÐµÐ¼ Ð³Ð»Ð°Ð²Ð°Ð¼. Ð Ð¿ÐµÑÐ²Ð¾Ð¹ Ð³Ð»Ð°Ð²Ðµ ÐºÑÐ°ÑÐºÐ¾ Ð¾Ð±ÑÑÐ¶Ð´Ð°ÑÑÑÑ Ð³ÐµÐ¾Ð¼ÐµÑÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ Ð¾ Ð±Ð°Ð·Ð¸ÑÐ°Ñ ÑÑÐ½ÐºÑÐ¸Ð¹, ÑÑÐ¾ Ð¿Ð¾Ð·Ð²Ð¾Ð»ÑÐµÑ Ð·Ð°ÑÐµÐ¼ Ð¿Ð¾ÑÐ»ÐµÐ´Ð¾Ð²Ð°ÑÐµÐ»ÑÐ½Ð¾ ÑÐ°ÑÑÐ¼Ð¾ÑÑÐµÑÑ Ð¼ÐµÑÐ¾Ð´Ñ Ð´Ð¸ÑÐºÑÐµÑÐ½Ð¾Ð³Ð¾ Ð¸ Ð½ÐµÐ¿ÑÐµÑÑÐ²Ð½Ð¾Ð³Ð¾ Ð¿ÑÐµÐ¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ð¹ Ð¤ÑÑÑÐµ. ÐÐ¾ Ð²ÑÐ¾ÑÐ¾Ð¹ Ð³Ð»Ð°Ð²Ðµ Ð²Ð²Ð¾Ð´Ð¸ÑÑÑ Ð¸Ð½ÑÐµÐ³ÑÐ°Ð»ÑÐ½Ð¾Ðµ Ð²ÐµÐ¹Ð²Ð»ÐµÑ-Ð¿ÑÐµÐ¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ðµ, Ð² ÑÑÐµÑÑÐµÐ¹ Ð³Ð»Ð°Ð²Ðµ ÑÐ°ÑÑÐ¼Ð°ÑÑÐ¸Ð²Ð°ÑÑÑÑ Ð¿Ð¾Ð½ÑÑÐ¸Ñ ÐºÑÐ°ÑÐ½Ð¾- Ð¼Ð°ÑÑÑÐ°Ð±Ð½Ð¾Ð³Ð¾ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð¸ Ð´Ð¸ÑÐºÑÐµÑÐ½Ð¾Ð³Ð¾ (Ð±ÑÑÑÑÐ¾Ð³Ð¾) Ð²ÐµÐ¹Ð²Ð»ÐµÑ- Ð¿ÑÐµÐ¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ñ. Ð¢ÐµÐ¾ÑÐµÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð¿Ð¾ÑÑÑÐ¾ÐµÐ½Ð¸Ñ Ð¿ÑÐ¾Ð¸Ð»Ð»ÑÑÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ñ Ð¿ÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ¸Ð¼Ð¸ Ð¿ÑÐ¸Ð¼ÐµÑÐ°Ð¼Ð¸, Ð´ÐµÐ¼Ð¾Ð½ÑÑÑÐ¸ÑÑÑÑÐ¸Ð¼Ð¸ Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½Ð¾ÑÑÐ¸ ÑÐ°ÑÑÐ¼Ð°ÑÑÐ¸Ð²Ð°ÐµÐ¼ÑÑ Ð¼ÐµÑÐ¾Ð´Ð¾Ð² Ð² Ð·Ð°Ð´Ð°ÑÐ°Ñ ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° ÑÑÐ°ÑÐ¸Ð¾Ð½Ð°ÑÐ½ÑÑ Ð¸ Ð½ÐµÑÑÐ°ÑÐ¸Ð¾Ð½Ð°ÑÐ½ÑÑ Ð¿ÑÐ¾ÑÐµÑÑÐ¾Ð². Ð Ð¿ÑÐ¸Ð»Ð¾Ð¶ÐµÐ½Ð¸Ð¸ Ð´Ð°Ð½Ñ Ð¾Ð¿Ð¸ÑÐ°Ð½Ð¸Ñ ÑÐ¿ÑÐ¾ÑÐµÐ½Ð½ÑÑ Ð°Ð»Ð³Ð¾ÑÐ¸ÑÐ¼Ð¾Ð², Ð¿ÑÐµÐ´Ð½Ð°Ð·Ð½Ð°ÑÐµÐ½Ð½ÑÐµ Ð´Ð»Ñ ÑÐ°Ð¼Ð¾ÑÑÐ¾ÑÑÐµÐ»ÑÐ½ÑÑ ÑÐ¿ÑÐ°Ð¶Ð½ÐµÐ½Ð¸Ð¹ Ð¿ÑÐ¸ Ð¿ÐµÑÐ²Ð¾Ð¼ Ð·Ð½Ð°ÐºÐ¾Ð¼ÑÑÐ²Ðµ Ñ Ð²ÐµÐ¹Ð²Ð»ÐµÑÐ°Ð¼Ð¸. ÐÐ¾ÑÐ¾Ð±Ð¸Ðµ Ð¼Ð¾Ð¶ÐµÑ Ð±ÑÑÑ Ð¿Ð¾Ð»ÐµÐ·Ð½Ð¾ ÑÑÑÐ´ÐµÐ½ÑÐ°Ð¼ Ð¸ Ð°ÑÐ¿Ð¸ÑÐ°Ð½ÑÐ°Ð¼ ÑÐ¸Ð·Ð¸ÑÐµÑÐºÐ¸Ñ ÑÐ¿ÐµÑÐ¸Ð°Ð»ÑÐ½Ð¾ÑÑÐµÐ¹, Ð¿ÑÐ¸ÑÑÑÐ¿Ð°ÑÑÐ¸Ð¼ Ðº Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ ÑÐ¾Ð²ÑÐµÐ¼ÐµÐ½Ð½ÑÑ Ð¼ÐµÑÐ¾Ð´Ð¾Ð² Ð¾Ð±ÑÐ°Ð±Ð¾ÑÐºÐ¸ ÑÐ¸Ð³Ð½Ð°Ð»Ð¾Ð².
description: ÐÐµÑÐ°ÑÐ°ÐµÑÑÑ Ð¿Ð¾ ÑÐµÑÐµÐ½Ð¸Ñ ÑÐµÐ´Ð°ÐºÑÐ¸Ð¾Ð½Ð½Ð¾-Ð¸Ð·Ð´Ð°ÑÐµÐ»ÑÑÐºÐ¾Ð³Ð¾ ÑÐ¾Ð²ÐµÑÐ° Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¾Ð³Ð¾ Ð³Ð¾ÑÑÐ´Ð°ÑÑÑÐ²ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑÐ°.
CONOSCENZA USABILE? LA VALUTAZIONE DELLE POLITICHE PUBBLICHE NEI PROCESSI DECISIONALI DELLA REGIONE LOMBARDIA
Creators: name: GENTILI, GIOVANNI
Publisher: name: Universit� degli Studi di Milano
Year: 2019

description: La valutazione delle politiche pubbliche � uno strumento sempre pi� importante per lo sviluppo delle stesse e per svolgere al meglio la funzione di controllo in capo ai legislativi. Per rispondere ad un problema collettivo i decisionmaker hanno bisogno di capire se una politica, pensata e attuata negli anni precedenti, ha prodotto gli effetti sperati. Il problema � che il personale politico spesso dimostra uno scarso interesse verso la valutazione e i suoi risultati perch� maggiormente propenso alla ricerca del consenso piuttosto che allo sviluppo di buone politiche o al raggiungimento di effettivi risultati. In alcuni contesti, tuttavia, i risultati della valutazione hanno un peso maggiore che in altri nell?indirizzare il disegno delle nuove policy. L?obiettivo di questa ricerca � quello di osservare queste differenze e capire quali fattori incidano su un effettivo uso della valutazione. Il tutto sar� effettuato tramite uno studio qualitativo con analisi documentale e interviste a valutatori e consiglieri regionali nel contesto di Regione Lombardia. Lo studio apre un interessante dibattito sull?uso della valutazione nelle regioni italiane, tema ancora poco approfondito in termini di ricerca empirica.
Influence of the Nd $4f$ states on the magnetic behavior and the electric field gradient of the oxypnictides superconductors NdFeAsO$_{1-x}$F$_x$
Creators: name: Jeglic, P.
name: Bos, J. -W. G.
name: Zorko, A.
name: Brunelli, M.
name: Koch, K.
name: Rosner, H.
name: Margadonna, S.
name: Arcon, D.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The structural, electronic, and magnetic properties of the superconducting NdFeAsO$_{1-x}$F$_{x}$ phases ($T_C=43 {\rm K}$ for $x=0.15$) have been investigated experimentally by high-resolution synchrotron x-ray powder diffraction, magnetization and $^{75}$As NMR measurements. Density-functional calculations were performed to calculate and analyze the electric field gradient and the density of states. Compared to LaFeAsO family, the NdFeAsO family shows a contraction of the lattice parameters with shorter rare-earth (RE)-As bond distances, an increased thickness of the As-Fe$_2$-As layer, and less distorted Fe-As$_4$ tetrahedra. The $^{75}$As quadrupole frequencies are enhanced with respect to the La analogs. This is due to a more prolate As $4p$ electron distribution mainly caused by the reduced lattice parameters and not by the presence of Nd $4f$ electrons. A non-negligible hyperfine coupling between the $^{75}$As nuclei and the Nd $4f$ states indicates a weak coupling between the REO and FeAs layer and possibly opens the channel for a Ruderman-Kittel-Kasuya-Yosida (RKKY)-type interaction between localized Nd $4f$ moments mediated by itinerant Fe 3d and/or Nd $5d$ states.
description: 7 pages, 6 figures, replaces 0806.1450
title: ÐÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð°Ñ ÑÐµÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ñ ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸Ð¸ ÐÐ½ÑÐµÑÐ½ÐµÑÐ° Ð²ÐµÑÐµÐ¹
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
Creators: name: ÐÐµÐ´Ð½Ð¸ÐºÐ¾Ð², ÐÐ¸ÐºÐ¸ÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2018
Subjects: ÐÐ½ÑÐµÑÐ½ÐµÑ
Ð Ð°ÑÐ¿Ð¾Ð·Ð½Ð°ÑÑÐ¸Ðµ ÑÐ¸ÑÑÐµÐ¼Ñ Ð¸ ÑÑÑÑÐ¾Ð¹ÑÑÐ²Ð°

description: ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¾ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¸Ð½ÐµÑÑÐ¸Ð°Ð»ÑÐ½ÑÑ Ð¸Ð·Ð¼ÐµÑÐ¸ÑÐµÐ»ÑÐ½ÑÑ Ð¼Ð¾Ð´ÑÐ»ÐµÐ¹. ÐÑÐ¿Ð¾Ð»Ð½ÐµÐ½ Ð°Ð½Ð°Ð»Ð¸Ð· ÑÑÑÐµÑÑÐ²ÑÑÑÐ¸Ñ ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ñ ÑÐµÑÐµÐ½Ð¸Ð¹ Ð² Ð¾Ð±Ð»Ð°ÑÑÐ¸ ÑÐµÐ³Ð¸ÑÑÑÐ°ÑÐ¸Ð¸, Ð²Ð¸Ð·ÑÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¸ ÐºÐ»Ð°ÑÑÐ¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¸ Ð´Ð²Ð¸Ð¶ÐµÐ½Ð¸Ð¹ Ð² ÑÐ¿Ð¾ÑÑÐ¸Ð²Ð½Ð¾Ð¹ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸, Ð²ÑÑÐ²Ð»ÐµÐ½Ñ Ð¸Ñ Ð´Ð¾ÑÑÐ¾Ð¸Ð½ÑÑÐ²Ð° Ð¸ Ð½ÐµÐ´Ð¾ÑÑÐ°ÑÐºÐ¸. Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð° ÑÐ¸ÑÑÐµÐ¼Ð° ÑÐµÐ³Ð¸ÑÑÑÐ°ÑÐ¸Ð¸, Ð²Ð¸Ð·ÑÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¸ ÑÐ°ÑÐ¿Ð¾Ð·Ð½Ð°Ð²Ð°Ð½Ð¸Ñ ÑÑÑÐºÐ¾Ð² Ð² ÑÐºÐµÐ¹ÑÐ±Ð¾ÑÐ´Ð¸Ð½Ð³Ðµ.
Supermassive Black Hole Formation by Direct Collapse: Keeping Protogalactic Gas H_2--Free in Dark Matter Halos with Virial Temperatures T_vir >~ 10^4 K
Creators: name: Shang, Cien
name: Bryan, Greg
name: Haiman, Zoltan
Publisher: name: arXiv
Year: 2009
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: In the absence of H_2 molecules, the primordial gas in early dark matter halos with virial temperatures just above T_vir >~ 10^4 K cools by collisional excitation of atomic H. Although it cools efficiently, this gas remains relatively hot, at a temperature near T ~ 8000 K, and consequently might be able to avoid fragmentation and collapse directly into a supermassive black hole (SMBH). In order for H_2--formation and cooling to be strongly suppressed, the gas must be irradiated by a sufficiently intense ultraviolet (UV) flux. We performed a suite of three--dimensional hydrodynamical adaptive mesh refinement (AMR) simulations of gas collapse in three different protogalactic halos with T_vir >~ 10^4 K, irradiated by a UV flux with various intensities and spectra. We determined the critical specific intensity, Jcrit, required to suppress H_2 cooling in each of the three halos. For a hard spectrum representative of metal--free stars, we find (in units of 10^{-21} erg s^{-1} Hz^{-1} sr^{-1} cm^{-2}) 10^4
description: 15 pages, 13 figures, submitted to MNRAS
Equation of state and QCD transition at finite temperature
Creators: name: Bazavov, A.
name: Bhattacharya, T.
name: Cheng, M.
name: Christ, N. H.
name: DeTar, C.
name: Ejiri, S.
name: Gottlieb, Steven
name: Gupta, R.
name: Heller, U. M.
name: Huebner, K.
name: Jung, C.
name: Karsch, F.
name: Laermann, E.
name: Levkova, L.
name: Miao, C.
name: Mawhinney, R. D.
name: Petreczky, P.
name: Schmidt, C.
name: Soltz, R. A.
name: Soeldner, W.
name: Sugar, R.
name: Toussaint, D.
name: Vranas, P.
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We calculate the equation of state in 2+1 flavor QCD at finite temperature with physical strange quark mass and almost physical light quark masses using lattices with temporal extent Nt=8. Calculations have been performed with two different improved staggered fermion actions, the asqtad and p4 actions. Overall, we find good agreement between results obtained with these two O(a^2) improved staggered fermion discretization schemes. A comparison with earlier calculations on coarser lattices is performed to quantify systematic errors in current studies of the equation of state. We also present results for observables that are sensitive to deconfining and chiral aspects of the QCD transition on Nt=6 and 8 lattices. We find that deconfinement and chiral symmetry restoration happen in the same narrow temperature interval. In an Appendix we present a simple parametrization of the equation of state that can easily be used in hydrodynamic model calculations. In this parametrization we also incorporated an estimate of current uncertainties in the lattice calculations which arise from cutoff and quark mass effects. We estimate these systematic effects to be about 10 MeV
description: 31 pages, 24 EPS-figures
Identification of novel peptide inhibitors of Plasmodium falciparum dihydrofolate reductase (PfDHFR): molecular docking and MD simulation studies
Creators: name: Devi, Kanika
name: Chandra, Anshuman
name: Kumar, Virender
name: Othayoth, Jithesh
name: Rathi, Brijesh
name: Goel, Vijay Kumar
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: The presence of drug-resistant variants of Plasmodium parasites within the population has presented a substantial obstacle to the eradication of Malaria. As a result, numerous research groups have directed their efforts towards creating new medication candidates that specifically target parasites. In this study, our main objective was to identify tri-peptide inhibitors for Plasmodium falciparum Dihydrofolate Reductase (PfDHFR) with the aim of finding a new peptide that exhibits superior binding properties compared to the current inhibitor, WR99210. In order to achieve this objective, a virtual library consisting of 8000 tripeptides was generated and subjected to computational screening against wild-type PfDHFR. The purpose of this screening was to discover the most effective binders at the active site. The four most optimal tripeptides identified (Trp-Trp-Glu, Trp-Phe-Tyr, Phe-Trp-Trp, Tyr-Trp-Trp) exhibited significant non-covalent interactions inside the active site of PfDHFR and had binding energies ranging from −9.5 to −9.0 kcal/mol and WR99210 had a binding energy of −6.2 kcal/mol. A 250 ns Molecular Dynamics (MD) simulation was performed to investigate the kinetic and thermodynamic characteristics of the protein-ligand complexes. The Root Mean Square Deviation (RMSD) values for the optimal tripeptides fell within the allowed range, indicating the stability of the ligands inside the protein complex. The Ki value for the most effective tripeptide was 0.3482 µM, whereas WR99210 had a Ki value of 1.02 µM. This article presents the initial discovery of peptide inhibitors targeting PfDHFR. In this text, we provide a comprehensive explanation of the interactions that occur between peptides and the enzyme.
title: ÐÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ñ Ð¸ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¸Ðµ ÑÐ¿ÐµÑÐ¸Ð°Ð»ÑÐ½ÑÑ Ð¼ÐµÑÐ¾Ð¿ÑÐ¸ÑÑÐ¸Ð¹ ÐºÐ°Ðº ÑÑÐµÐ´ÑÑÐ²Ð° Ð¿ÑÐ¾Ð´Ð²Ð¸Ð¶ÐµÐ½Ð¸Ñ ÐºÐ¾Ð¼Ð¿Ð°Ð½Ð¸Ð¸ Ð½Ð° ÑÑÐ½Ð¾Ðº (Ð½Ð° Ð¿ÑÐ¸Ð¼ÐµÑÐµ ÐºÐ¾Ð¼Ð¿Ð°Ð½Ð¸Ð¸ BTG Event Solutions)
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: Ð§ÑÐ³ÑÐ½Ð¾Ð²Ð°, ÐÐ°Ð´ÐµÐ¶Ð´Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: ÑÐ¿ÐµÑÐ¸Ð°Ð»ÑÐ½ÑÐµ Ð¼ÐµÑÐ¾Ð¿ÑÐ¸ÑÑÐ¸Ñ
Ð¿ÑÐ¾Ð´Ð²Ð¸Ð¶ÐµÐ½Ð¸Ðµ ÐºÐ¾Ð¼Ð¿Ð°Ð½Ð¸Ð¸
Ð°Ð½Ð°Ð»Ð¸Ð· Ð¼ÐµÑÐ¾Ð¿ÑÐ¸ÑÑÐ¸Ð¹
Event Ð¸Ð½Ð´ÑÑÑÑÐ¸Ñ

description: Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð¸Ð·Ð»Ð¾Ð¶ÐµÐ½Ð° ÑÑÑÐ½Ð¾ÑÑÑ Ð¿Ð¾Ð´ÑÐ¾Ð´Ð° Ðº ÑÑÐ°Ð¿Ð°Ð¼ Ð¿Ð¾Ð´Ð³Ð¾ÑÐ¾Ð²ÐºÐ¸ Ð¸ ÑÐµÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ ÑÐ¿ÐµÑÐ¸Ð°Ð»ÑÐ½ÑÑ Ð¼ÐµÑÐ¾Ð¿ÑÐ¸ÑÑÐ¸Ð¹. ÐÐ°Ð½Ñ Ð¾Ð±ÑÐ¸Ðµ Ð¿Ð¾Ð½ÑÑÐ¸Ñ Ð¸ ÐºÐ»Ð°ÑÑÐ¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¸ ÑÐ¿ÐµÑÐ¸Ð°Ð»ÑÐ½ÑÑ Ð¼ÐµÑÐ¾Ð¿ÑÐ¸ÑÑÐ¸Ð¹ Ð¸ Ð¸Ñ Ð¿ÑÐ¾Ð´Ð²Ð¸Ð¶ÐµÐ½Ð¸Ñ. ÐÐ·ÑÑÐµÐ½Ð° Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÑ event Ð¸Ð½Ð´ÑÑÑÑÐ¸Ð¸ Ð½Ð° Ð¿ÑÐ¸Ð¼ÐµÑÐµ BtG Event Solutions, Ð±ÑÐ»Ð¸ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ñ SWOT Ð¸ STEP Ð°Ð½Ð°Ð»Ð¸Ð·Ñ. Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ñ ÑÐµÐºÐ¾Ð¼ÐµÐ½Ð´Ð°ÑÐ¸Ð¸ Ð¿Ð¾ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾Ð¼Ñ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¸Ñ Ð¸ Ð¿ÑÐ¾Ð´Ð²Ð¸Ð¶ÐµÐ½Ð¸Ñ ÐºÐ¾Ð¼Ð¿Ð°Ð½Ð¸Ð¸ Ð½Ð° ÑÑÐ½Ð¾Ðº.
CP-phase effects on the effective neutrino mass $m_{ee}$ in the case of quasi-degenerate neutrinos
Creators: name: Maalampi, J.
name: Riittinen, J.
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the possibility that the three mass states of the ordinary active neutrinos actually split into pairs of quasi-degenerate states, with $Δm^2_{kk'} \sim 10^{-12}$ eV$^2$ or less, as a result of mixing of active neutrinos with sterile neutrinos. Although these quasi-degenerate pairs will look in laboratory experiment identical to single active states, the CP phase factors associated with active-sterile mixing might cause cancellations in the effective electron neutrino mass $m_{ee}$ measured in the neutrinoless double beta decay experiments thereby revealing the split nature of states.
description: 6 pages, 1 figure
Breaking Halo Occupation Degeneracies with Marked Statistics
Creators: name: White, Martin
name: Padmanabhan, Nikhil
Publisher: name: arXiv
Year: 2008
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We show that a suitably defined marked correlation function can be used to break degeneracies in halo-occupation distribution modeling. The statistic can be computed on both 3D and 2D data sets, and should be applicable to all upcoming galaxy surveys. A proof of principle, using mock catalogs created from N-body simulations, is given.
description: 4 pages, 3 figures, minor revisions to match version accepted by MNRAS
Peroneus quartus tendon and complete rupture of peroneus brevis tendon
Creators: name: Savastano, Sergio
Publisher: name: EURORAD
Year: 2014
Subjects: subject: Musculoskeletal joint
subject: Musculoskeletal system
subject: MR
subject: Plain radiographic studies
subject: Diagnostic procedure
subject: Trauma

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: male, 50 years
description: Clinical History: The patient complained a lateral retromalleolar pain after inversion sprain of the left ankle. Perimalleolar edema, tenderness of the lateral aspect of the ankle and difficulty walking were evident on physical examination. A fluoroquinolone antibiotic was... Final Diagnosis: Complete rupture of peroneal brevis tendon; peroneus quartus tendon
title: ÐÐ²ÑÐ¾Ð¼Ð°ÑÐ¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð°Ñ ÑÐ¸ÑÑÐµÐ¼Ð° Ð°Ð½Ð°Ð»Ð¸Ð·Ð° ÐºÐ¸Ð±ÐµÑÑÐ³ÑÐ¾Ð· Ð² ÐºÑÐ¸ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ Ð¸Ð½ÑÑÐ°ÑÑÑÑÐºÑÑÑÐµ
title: ÑÐ¿ÐµÑÐ¸Ð°Ð»ÑÐ½Ð¾ÑÑÑ 05.13.19 "ÐÐµÑÐ¾Ð´Ñ Ð¸ ÑÐ¸ÑÑÐµÐ¼Ñ Ð·Ð°ÑÐ¸ÑÑ Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¸, Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ Ð±ÐµÐ·Ð¾Ð¿Ð°ÑÐ½Ð¾ÑÑÑ"
titleType: Subtitle
Creators: name: ÐÑÑÐ½Ð´ÑÑÐµÐ², ÐÐ°ÑÐ¸Ð»Ð¸Ð¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2021
Subjects: ÐÐ½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½ÑÐµ ÑÐ¸ÑÑÐµÐ¼Ñ
ÐÐ½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ñ
ÐÐ¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
Ð°Ð½Ð°Ð»Ð¸Ð· ÐºÐ¸Ð±ÐµÑÑÐ³ÑÐ¾Ð·
ÐºÑÐ¸ÑÐ¸ÑÐµÑÐºÐ°Ñ Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ Ð¸Ð½ÑÑÐ°ÑÑÑÑÐºÑÑÑÐ°
Ð¼ÐµÑÐ¾Ð´Ð¸ÐºÐ° Ð¾ÑÐµÐ½ÐºÐ¸ ÑÐ½Ð¸Ð¶ÐµÐ½Ð¸Ñ ÑÐ¸ÑÐºÐ°
Ð¼Ð¾Ð´ÐµÐ»Ñ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ ÐºÐ¾Ð¼Ð¿ÑÑÑÐµÑÐ½ÑÑ Ð°ÑÐ°Ðº
Ð½ÐµÐ¹ÑÐ¾-Ð½ÐµÑÐµÑÐºÐ°Ñ ÑÐ¸ÑÑÐµÐ¼Ð°

description: ÐÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½ Ð½Ð¾Ð²ÑÐ¹ Ð¿Ð¾Ð´ÑÐ¾Ð´ Ðº ÑÐ½Ð¸Ð¶ÐµÐ½Ð¸Ñ ÑÐ¸ÑÐºÐ° ÑÐµÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ ÐºÐ¸Ð±ÐµÑÑÐ³ÑÐ¾Ð· Ð² ÐºÑÐ¸ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ Ð¸Ð½ÑÑÐ°ÑÑÑÑÐºÑÑÑÐµ (ÐÐÐ), Ð·Ð°ÐºÐ»ÑÑÐ°ÑÑÐ¸Ð¹ÑÑ Ð² Ð°Ð´Ð°Ð¿ÑÐ¸Ð²Ð½Ð¾Ð¼ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ð¸ Ð¾Ð±Ð½Ð°ÑÑÐ¶ÐµÐ½Ð¸ÐµÐ¼ ÐºÐ¾Ð¼Ð¿ÑÑÑÐµÑÐ½ÑÑ Ð°ÑÐ°Ðº Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð½ÐµÐ¿ÑÐµÑÑÐ²Ð½Ð¾Ð³Ð¾ Ð²ÑÐ±Ð¾ÑÐ° Ð¿ÑÐ¸Ð¼ÐµÐ½ÑÐµÐ¼ÑÑ Ð¼ÐµÑÐ¾Ð´Ð¾Ð² Ð¾Ð±Ð½Ð°ÑÑÐ¶ÐµÐ½Ð¸Ñ Ð°ÑÐ°Ðº, Ð¼Ð°ÐºÑÐ¸Ð¼Ð°Ð»ÑÐ½Ð¾ ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²ÑÑÑÐ¸Ñ ÑÐ¸Ð¿Ð°Ð¼ Ð´ÐµÐ¹ÑÑÐ²ÑÑÑÐ¸Ñ ÐºÐ¸Ð±ÐµÑÑÐ³ÑÐ¾Ð· Ð¸ Ð¸Ð·Ð¼ÐµÐ½ÑÑÑÐ¸Ð¼ÑÑ ÑÑÐ»Ð¾Ð²Ð¸ÑÐ¼ ÑÑÐ½ÐºÑÐ¸Ð¾Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÐÐÐ. Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð° Ð¼Ð°ÑÐµÐ¼Ð°ÑÐ¸ÑÐµÑÐºÐ°Ñ Ð¼Ð¾Ð´ÐµÐ»Ñ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ ÐºÐ¾Ð¼Ð¿ÑÑÑÐµÑÐ½ÑÑ Ð°ÑÐ°Ðº Ð½Ð° ÐÐÐ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ ÑÐ°ÑÑÐ¸ÑÐµÐ½Ð¸Ñ Ð±Ð°Ð·Ð¾Ð²Ð¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸ ÐÐ¾ÑÐºÐ¸-ÐÐ¾Ð»ÑÑÐµÑÑÑ. ÐÐ¾ÑÑÑÐ¾ÐµÐ½Ð° Ð°Ð´Ð°Ð¿ÑÐ¸Ð²Ð½Ð°Ñ ÑÐ¸ÑÑÐµÐ¼Ð° ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ Ð¾Ð±Ð½Ð°ÑÑÐ¶ÐµÐ½Ð¸ÐµÐ¼ ÐºÐ¾Ð¼Ð¿ÑÑÑÐµÑÐ½ÑÑ Ð°ÑÐ°Ðº Ð² ÐÐÐ, Ð¿Ð¾Ð´Ð´ÐµÑÐ¶Ð¸Ð²Ð°ÑÑÐ°Ñ Ð²ÑÑÐ¾ÐºÑÑ ÑÐ¾ÑÐ½Ð¾ÑÑÑ Ð¾Ð±Ð½Ð°ÑÑÐ¶ÐµÐ½Ð¸Ñ Ð°ÑÐ°Ðº Ð² Ð¸Ð·Ð¼ÐµÐ½ÑÑÑÐ¸ÑÑÑ ÑÑÐ»Ð¾Ð²Ð¸ÑÑ Ð¿ÑÐ¸Ð½ÑÑÐ¸Ñ ÑÐµÑÐµÐ½Ð¸Ñ Ð·Ð° ÑÑÐµÑ Ð½ÐµÐ¿ÑÐµÑÑÐ²Ð½Ð¾Ð³Ð¾ Ð½ÐµÐ¹ÑÐ¾-Ð½ÐµÑÐµÑÐºÐ¾Ð³Ð¾ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° ÐºÐ¸Ð±ÐµÑÑÐ³ÑÐ¾Ð· Ð¸ Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÐ¾Ð² Ð¾Ð±ÑÐµÐºÑÐ° Ð·Ð°ÑÐ¸ÑÑ.ÐÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ð° Ð¼ÐµÑÐ¾Ð´Ð¸ÐºÐ° Ð¾ÑÐµÐ½ÐºÐ¸ ÑÐ½Ð¸Ð¶ÐµÐ½Ð¸Ñ ÑÐ¸ÑÐºÐ° ÑÐµÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ ÐºÐ¸Ð±ÐµÑÑÐ³ÑÐ¾Ð· Ð² ÐÐÐ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²ÐµÐ½Ð½Ð¾Ð¹ Ð°Ð´Ð°Ð¿ÑÐ¸Ð²Ð½Ð¾Ð¹ Ð¾ÑÐµÐ½ÐºÐ¸ ÑÐ¸ÑÐºÐ°, ÑÑÐ¸ÑÑÐ²Ð°ÑÑÐµÐ¹ ÑÐ¸Ð¿Ð¸Ð·Ð°ÑÐ¸Ñ Ð¸ ÑÐ°Ð¼Ð¾Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ñ ÑÐµÑÐµÐ²ÑÑ ÑÑÑÑÐºÑÑÑ Ð¸ Ð¿Ð¾Ð´ÑÐ¸ÑÑÐµÐ¼ ÐÐÐ.
Measurement of the K+ -> pi0 mu+ nu_mu gamma Branching Ratio
Creators: name: The E787 Collaboration
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: A measurement of the decay K+ -> pi0 mu+ nu_mu gamma has been performed with the E787 detector at Brookhaven National Laboratory. Forty events were observed in the signal region with the background expectation of (16.5 +- 2.7) events. The branching ratio was measured to be (1.58 +- 0.46(stat.) +- 0.08(syst.)) x 10^{-5}} in the kinematic region Eg >30 MeV and theta_{mu gamma} > 20degree, where Eg is the energy of the emitted photon and theta_{mu gamma} is the angle between the muon and the photon in the K+ rest frame. The results were consistent with theoretical predictions.
description: 11 pages, 10 figures; revised manuscript, no change in the results, accepted for publication as a Regular Article in Physical Review D
Phenomenological Consequences of the Constrained Exceptional Supersymmetric Standard Model
Creators: name: Athron, P.
name: King, S. F.
name: Miller, D. J.
name: Moretti, S.
name: Nevzorov, R.
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The Exceptional Supersymmetric Standard Model (E$_6$SSM) provides a low energy alternative to the MSSM, with an extra gauged U(1)$_N$ symmetry, solving the $μ$-problem of the MSSM. Inspired by the possible embedding into an E$_6$ GUT, the matter content fills three generations of E$_6$ multiplets, thus predicting exciting exotic matter such as diquarks or leptoquarks. We present predictions from a constrained version of the model (cE$_6$SSM), with a universal scalar mass $m_0$, trilinear mass $A$ and gaugino mass $M_{1/2}$. We reveal a large volume of the cE$_6$SSM parameter space where the correct breakdown of the gauge symmetry is achieved and all experimental constraints satisfied. We predict a hierarchical particle spectrum with heavy scalars and light gauginos, while the new exotic matter can be light or heavy depending on parameters. We present representative cE$_6$SSM scenarios, demonstrating that there could be light exotic particles, like leptoquarks and a U(1)$_N$ Z' boson, with spectacular signals at the LHC.
description: Contribution to the proceedings of SUSY 09, Boston, USA, June 2009, 4 pages
RECOMMENDATION SYSTEMS IN SOCIAL NETWORKS
Creators: name: Jafari, Behafarid Mohammad
Publisher: name: Purdue University Graduate School
Year: 2023
Subjects: Natural language processing
Knowledge representation and reasoning
Data mining and knowledge discovery
Graph, social and multimedia data
Recommender systems

description: The dramatic improvement in information and communication technology (ICT) has made an evolution in learning management systems (LMS). The rapid growth in LMSs has caused users to demand more advanced, automated, and intelligent services. CourseNetworking is a next-generation LMS adopting machine learning to add personalization, gamification, and more dynamics to the system. This work tries to come up with two recommender systems that can help improve CourseNetworking services. The first one is a social recommender system helping CourseNetworking to track user interests and give more relevant recommendations. Recently, graph neural network (GNN) techniques have been employed in social recommender systems due to their high success in graph representation learning, including social network graphs. Despite the rapid advances in recommender systems performance, dealing with the dynamic property of the social network data is one of the key challenges that is remained to be addressed. In this research, a novel method is presented that provides social recommendations by incorporating the dynamic property of social network data in a heterogeneous graph by supplementing the graph with time span nodes that are used to define users long-term and short-term preferences over time. The second service that is proposed to add to Rumi services is a hashtag recommendation system that can help users label their posts quickly resulting in improved searchability of content. In recent years, several hashtag recommendation methods are proposed and developed to speed up processing of the texts and quickly find out the critical phrases. The methods use different approaches and techniques to obtain critical information from a large amount of data. This work investigates the efficiency of unsupervised keyword extraction methods for hashtag recommendation and recommends the one with the best performance to use in a hashtag recommender system.
title: ÐÐ½Ð°Ð»Ð¸Ð· ÑÐ¸Ð½Ð°Ð½ÑÐ¾Ð²Ð¾Ð³Ð¾ ÑÐ¾ÑÑÐ¾ÑÐ½Ð¸Ñ Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ ÑÐ¾ÑÐ³Ð¾Ð²Ð»Ð¸
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ¾Ð»ÐºÐ¾Ð²Ð°, ÐÐ°Ð´ÐµÐ¶Ð´Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2018
Subjects: Ð°Ð½Ð°Ð»Ð¸Ð·
ÑÐ¸Ð½Ð°Ð½ÑÐ¾Ð²Ð°Ñ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÑ
Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ðµ
ÑÐ¸Ð½Ð°Ð½ÑÐ¾Ð²Ð¾Ðµ Ð¿Ð»Ð°Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
ÐÐÐ Â«ÐÐÐÐÐ ÐÐ Ð£ÐÐ"

description: Ð¦ÐµÐ»ÑÑ Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ ÑÐ²Ð»ÑÐµÑÑÑ Ð°Ð½Ð°Ð»Ð¸Ð· ÑÐ¸Ð½Ð°Ð½ÑÐ¾Ð²Ð¾Ð³Ð¾ ÑÐ¾ÑÑÐ¾ÑÐ½Ð¸Ñ Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ ÑÐ¾ÑÐ³Ð¾Ð²Ð»Ð¸ Ð½Ð° Ð¿ÑÐ¸Ð¼ÐµÑÐµ Ð¾Ð±ÑÐµÑÑÐ²Ð° Ñ Ð¾Ð³ÑÐ°Ð½Ð¸ÑÐµÐ½Ð½Ð¾Ð¹ Ð¾ÑÐ²ÐµÑÑÑÐ²ÐµÐ½Ð½Ð¾ÑÑÑÑ Â«ÐÐ´ÐµÐ°Ð» ÐÑÑÐ¿Ð¿Â» Ð¸ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¼ÐµÑÐ¾Ð¿ÑÐ¸ÑÑÐ¸Ð¹, Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð½ÑÑ Ð½Ð° ÑÐ»ÑÑÑÐµÐ½Ð¸Ðµ ÑÐ¸Ð½Ð°Ð½ÑÐ¾Ð²Ð¾Ð³Ð¾ ÑÐ¾ÑÑÐ¾ÑÐ½Ð¸Ñ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¸.
ÐÐ»Ñ Ð´Ð¾ÑÑÐ¸Ð¶ÐµÐ½Ð¸Ñ Ð¿Ð¾ÑÑÐ°Ð²Ð»ÐµÐ½Ð½Ð¾Ð¹ ÑÐµÐ»Ð¸ Ð¸Ð·ÑÑÐµÐ½Ñ ÑÐµÐ¾ÑÐµÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð¾ÑÐ½Ð¾Ð²Ñ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð¸ Ð¿ÑÐ¾Ð³Ð½Ð¾Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÑÐ¸Ð½Ð°Ð½ÑÐ¾Ð²Ð¾Ð³Ð¾ ÑÐ¾ÑÑÐ¾ÑÐ½Ð¸Ñ Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ, Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ð° ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ°Ñ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸ÐºÐ° Ð¾Ð±ÑÐµÑÑÐ²Ð° Ñ Ð¾Ð³ÑÐ°Ð½Ð¸ÑÐµÐ½Ð½Ð¾Ð¹ Ð¾ÑÐ²ÐµÑÑÑÐ²ÐµÐ½Ð½Ð¾ÑÑÑÑ Â«ÐÐ´ÐµÐ°Ð» ÐÑÑÐ¿Ð¿Â», Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½ Ð°Ð½Ð°Ð»Ð¸Ð· ÑÐ¸Ð½Ð°Ð½ÑÐ¾Ð²Ð¾Ð¹ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ ÐºÐ¾Ð¼Ð¿Ð°Ð½Ð¸Ð¸ Ð¸ Ð¿ÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ñ ÑÐµÐºÐ¾Ð¼ÐµÐ½Ð´Ð°ÑÐ¸Ð¸ Ð¿Ð¾ ÑÐ»ÑÑÑÐµÐ½Ð¸Ñ ÑÐ¸Ð½Ð°Ð½ÑÐ¾Ð²Ð¾Ð³Ð¾ ÑÐ¾ÑÑÐ¾ÑÐ½Ð¸Ñ.
The GALEX View of Supernova Hosts
Creators: name: Neill, James D.
name: Sullivan, Mark
name: Seibert, Mark
Publisher: name: arXiv
Year: 2008
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We exploit the accumulating, high-quality, multi-wavelength imaging data of nearby supernova (SN) hosts to explore the relationship between SN production and host galaxy evolution. The Galaxy Evolution Explorer (GALEX, Martin et al., 2005) provides ultraviolet (UV) imaging in two bands, complementing data in the optical and infra-red (IR). We compare host properties, derived from spectral energy distribution (SED) fitting, with nearby, well-observed SN Ia light curve properties. We also explore where the hosts of different types of SNe fall relative to the red and blue sequences on the galaxy UV-optical color-magnitude diagram (CMD, Wyder et al., 2007). We conclude that further exploration and larger samples will provide useful results for constraining the progenitors of SNe.
description: 4 pages, 3 figures, to appear in 'Probing Stellar Populations out to the Distant Universe', proceedings of a conference in Cefalu' Sicily (Italy) held September 7-19, 2008
First lensing measurements of SZ-discovered clusters
Creators: name: McInnes, Rachel N.
name: Menanteau, Felipe
name: Heavens, Alan F.
name: Hughes, John P.
name: Jimenez, Raul
name: Massey, Richard
name: Simon, Patrick
name: Taylor, Andy N.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present the first lensing mass measurements of Sunyaev-Zel'dovich (SZ) selected clusters. Using optical imaging from the Southern Cosmology Survey (SCS), we present weak lensing masses for three clusters selected by their SZ emission in the South Pole Telescope survey (SPT). We confirm that the SZ selection procedure is successful in detecting mass concentrations. We also study the weak lensing signals from 38 optically-selected clusters in ~8 square degrees of the SCS survey. We fit Navarro, Frenk and White (NFW) profiles and find that the SZ clusters have amongst the largest masses, as high as 5x10^14 Msun. Using the best fit masses for all the clusters, we analytically calculate the expected SZ integrated Y parameter, which we find to be consistent with the SPT observations.
description: Minor changes to match accepted version, 5 pages, 3 figures
title: ÐÐ¾Ð²ÑÑÐµÐ½Ð¸Ðµ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð·Ð°ÐºÑÐ¿Ð¾ÑÐ½Ð¾Ð¹ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: ÐÑÐ´Ð°ÑÐµÐ²Ð°, ÐÐ¾Ð»Ð¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: ÑÐ¾ÑÐ³Ð¾Ð²ÑÐµ Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ
Ð·Ð°ÐºÑÐ¿Ð¾ÑÐ½Ð°Ñ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÑ
ÑÑÑÐ´Ð¾Ð²ÑÐµ ÑÐµÑÑÑÑÑ
Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»ÑÐ½ÑÐµ ÑÐµÑÑÑÑÑ

description: ÐÑÐ¿Ð¾Ð»Ð½ÐµÐ½ Ð°Ð½Ð°Ð»Ð¸Ð· ÑÐµÐºÑÑÐµÐ³Ð¾ ÑÐ¾ÑÑÐ¾ÑÐ½Ð¸Ñ ÑÐ¾ÑÐ³Ð¾Ð²Ð¾Ð¹ Ð¾ÑÑÐ°ÑÐ»Ð¸ Ð² Ð Ð¾ÑÑÐ¸Ð¹ÑÐºÐ¾Ð¹ Ð¤ÐµÐ´ÐµÑÐ°ÑÐ¸Ð¸, Ð¿ÑÐ¾Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½ ÑÑÐ¾Ð²ÐµÐ½Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐµÑÑÑÑÐ½Ð¾Ð³Ð¾ Ð¿Ð¾ÑÐµÐ½ÑÐ¸Ð°Ð»Ð° ÑÐ¾Ð·Ð½Ð¸ÑÐ½Ð¾Ð³Ð¾ ÑÐ¾ÑÐ³Ð¾Ð²Ð¾Ð³Ð¾ Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ, Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¾ ÑÐ¾ÑÑÐ¾ÑÐ½Ð¸Ðµ ÑÑÑÐ´Ð¾Ð²ÑÑ, Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»ÑÐ½ÑÑ Ð¸ ÑÐ¸Ð½Ð°Ð½ÑÐ¾Ð²ÑÑ ÑÐµÑÑÑÑÐ¾Ð² ÐÐÐ Â«ALBA CORPORATION LTDÂ», Ð²ÑÑÐ²Ð»ÐµÐ½Ñ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ Ð¿Ð¾Ð²ÑÑÐµÐ½Ð¸Ñ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð·Ð°ÐºÑÐ¿Ð¾ÑÐ½Ð¾Ð¹ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ ÑÐ¾ÑÐ³Ð¾Ð²Ð¾Ð³Ð¾ Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ, Ð¿ÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ñ Ð¿ÑÑÐ¸ Ð¿Ð¾Ð²ÑÑÐµÐ½Ð¸Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÑÑÐ´Ð¾Ð²ÑÑ, Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»ÑÐ½ÑÑ Ð¸ ÑÐ¸Ð½Ð°Ð½ÑÐ¾Ð²ÑÑ ÑÐµÑÑÑÑÐ¾Ð².
Evaluation of the efficacy of marine natural products against PARP-1/2 proteins in high-grade serous ovarian cancer: insights into MD and SMD simulations
Creators: name: Priyankha, Sridhar
name: Prakash, Muthuramalingam
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: High-grade serous ovarian cancer (HGSOC) is the most malignant and ubiquitous phenotype of epithelial ovarian cancer. Originating in the fallopian tubes and rapidly spreading to the ovaries, this highly heterogeneous disease is a result of serous tubal intraepithelial carcinoma. The proteins known as poly(ADP-ribose) polymerase (PARP) aid in the development of HGSOC by repairing the cancer cells that proliferate and spread metastatically. By using molecular docking to screen 1100 marine natural products (MNPs) from different marine environments against PARP-1/2 proteins, prominent PARP inhibitors (PARPi) were identified. Four compounds, alisiaquinone A, alisiaquinone C, ascomindone D and (+)-zampanolide referred to as MNP-1, MNP-2, MNP-3 and MNP-4, respectively, were chosen based on their binding affinity towards PARP-1/2 proteins, and their bioavailability and drug-like qualities were accessed using ADMET analysis. To investigate the structural stability and dynamics of these complexes, molecular dynamics simulations were performed for 200 ns. These results were compared with the complexes of olaparib (OLA), a PARPi that has been approved by the FDA for the treatment of advanced ovarian cancer. We determined that MNP-4 exhibited stronger binding energies with PARP-1/2 proteins than OLA by using MM/PBSA calculations. Hotspot residues from PARP-1 (E883, M890, Y896, D899 and Y907) and PARP-2 (Y449, F450, A451, S457 and Y460) showed strong interactions with the compounds. To comprehend the unbinding mechanism of MNP-4 complexed with PARP-1/2, steered molecular dynamics (SMD) simulations were performed. We concluded from the free energy landscape (FEL) map that PARP-1/2 are well-stabilised when the compound MNP-4 is bound rather than being pulled away from its binding pockets. This finding provides significant evidence regarding PARPi, which could potentially be employed in the therapeutic treatment of HGSOC.
Low Q2 Measurement of g2p and the LT Spin Polarizability
Creators: name: Slifer, K.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: JLab has been at the forefront of a program to measure the nucleon spin-dependent structure functions over a wide kinematic range, and data of unprecedented quality has been extracted in all three experimental halls. Moments of these quantities have proven to be powerful tools to test QCD sum rules and provide benchmark tests of Lattice QCD and Chiral Perturbation Theory. Precision measurements of $g_{1,2}^n$ and $g_1^p$ have been performed as part of the highly successful `extended GDH program', but data on the $g_2^p$ structure function remain scarce. We discuss here JLab experiment E08-027, which will measure quantity $g_2^p$ in the resonance region at low $Q^2$. These data will be used to test the Burkhardt-Cottingham sum rule and to extract the higher moments $δ_{LT}^p(Q^2)$ and $\overline{d}_2^p(Q^2)$. Data in the $Q^2$ range $0.02
description: Proceedings of the Spin Structure at Long Distance Workshop
title: Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¼ÐµÑÐ¾Ð´Ð¸ÐºÐ¸ ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ñ Ð¸Ð³ÑÐ¾Ð²Ð¾Ð³Ð¾ Ð¿ÐµÑÑÐ¾Ð½Ð°Ð¶Ð° World of Warcraft Ð½Ð° Ð¸Ð³ÑÐ¾Ð²Ð¾Ð¼ Ð´Ð²Ð¸Ð¶ÐºÐµ Unreal Engine 4
title: Ð¼Ð°Ð³Ð¸ÑÑÐµÑÑÐºÐ°Ñ Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ñ
titleType: Subtitle
Creators: name: ÐÐµÐ´Ð²ÐµÐ´ÐµÐ², ÐÐ°Ð²ÐµÐ»
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: ÐÐ°ÑÐ¸Ð½Ð½Ð°Ñ Ð³ÑÐ°ÑÐ¸ÐºÐ°
ÐÐ¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
Ð¸Ð³ÑÐ¾Ð²Ð¾Ð¹ Ð´Ð²Ð¸Ð¶Ð¾Ðº
ÑÐºÑÐ»ÑÐ¿ÑÐ¸Ð½Ð³
Ð¿Ð¾Ð»Ð¸Ð³Ð¾Ð½Ð°Ð»ÑÐ½Ð¾Ðµ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ

description: ÐÐ±ÑÐµÐºÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ - Ð¸Ð³ÑÐ¾Ð²Ð°Ñ Ð²ÑÐµÐ»ÐµÐ½Ð½Ð°Ñ World of WarCraft. ÐÑÐµÐ´Ð¼ÐµÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ - Ð¼ÐµÑÐ¾Ð´Ð¸ÐºÐ° ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ñ Ð¿Ð¾Ð»Ð¸Ð³Ð¾Ð½Ð°Ð»ÑÐ½Ð¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð¸Ð³ÑÐ¾Ð²Ð¾Ð³Ð¾ Ð¿ÐµÑÑÐ¾Ð½Ð°Ð¶Ð°. Ð¦ÐµÐ»Ñ ÑÐ°Ð±Ð¾ÑÑ - Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ðµ Ð½Ð°Ð¸Ð»ÑÑÑÐµÐ¹ Ð¼ÐµÑÐ¾Ð´Ð¸ÐºÐ¸ ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ñ Ð¸Ð³ÑÐ¾Ð²Ð¾Ð³Ð¾ Ð¿ÐµÑÑÐ¾Ð½Ð°Ð¶Ð° Ð¸ ÐµÑ Ð´Ð°Ð»ÑÐ½ÐµÐ¹ÑÐ°Ñ ÑÐµÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ñ Ð½Ð° Ð¸Ð³ÑÐ¾Ð²Ð¾Ð¼ Ð´Ð²Ð¸Ð¶ÐºÐµ. Ð ÑÐµÐ¾ÑÐµÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÐ°ÑÑÐ¸ ÑÐ°Ð±Ð¾ÑÑ Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸Ð»Ð¸ÑÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¼ÐµÑÐ¾Ð´Ð¾Ð² ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ñ Ð¿Ð¾Ð»Ð¸Ð³Ð¾Ð½Ð°Ð»ÑÐ½ÑÑ Ð¼Ð¾Ð´ÐµÐ»ÐµÐ¹ Ð¸ Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½ÑÐµ Ð²Ð°ÑÐ¸Ð°Ð½ÑÑ Ð¸Ñ ÑÐµÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸. Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð±ÑÐ»Ð¸ Ð²ÑÑÐ²Ð»ÐµÐ½Ñ Ð½Ð°Ð¸Ð»ÑÑÑÐ¸Ðµ Ð¼ÐµÑÐ¾Ð´Ñ Ð´Ð»Ñ ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ñ Ð¼Ð¾Ð´ÐµÐ»ÐµÐ¹ Ð¸Ð³ÑÐ¾Ð²ÑÑ Ð¿ÐµÑÑÐ¾Ð½Ð°Ð¶ÐµÐ¹, Ð° ÑÐ°ÐºÐ¶Ðµ ÑÐµÐºÐ¾Ð¼ÐµÐ½Ð´Ð°ÑÐ¸Ð¸ Ð¿Ð¾ ÑÐ°Ð¼Ð¾Ð¼Ñ Ð¾Ð¿ÑÐ¸Ð¼Ð°Ð»ÑÐ½Ð¾Ð¼Ñ Ð²Ð°ÑÐ¸Ð°Ð½ÑÑ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÑÑÐµÑÐ¼ÐµÑÐ½Ð¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð´Ð»Ñ Ð¿Ð¾ÑÐ»ÐµÐ´ÑÑÑÐµÐ¹ ÑÐµÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð±ÑÐ»Ð¸ Ð² Ð´Ð°Ð»ÑÐ½ÐµÐ¹ÑÐµÐ¼ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ñ Ð² Ð¿ÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÐ°ÑÑÐ¸ ÑÐ°Ð±Ð¾ÑÑ. ÐÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ°Ñ ÑÐ°ÑÑÑ ÑÐ°Ð±Ð¾ÑÑ Ð²ÐºÐ»ÑÑÐ°ÐµÑ Ð² ÑÐµÐ±Ñ Ð´Ð²Ðµ Ð³Ð»Ð°Ð²Ñ: Ð½ÐµÐ¿Ð¾ÑÑÐµÐ´ÑÑÐ²ÐµÐ½Ð½Ð¾ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÑ Ð¼ÐµÑÐ¾Ð´Ð¸ÐºÐ¸ Ð¸ Ð¾Ð±Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð¸Ðµ ÐµÑ Ð¿ÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð·Ð½Ð°ÑÐ¸Ð¼Ð¾ÑÑÐ¸. Ð Ð·Ð°ÐºÐ»ÑÑÐµÐ½Ð¸Ð¸ ÑÐ²ÐµÐ´ÐµÐ½Ñ Ð²Ð¾ÐµÐ´Ð¸Ð½Ð¾ Ð²ÑÐ²Ð¾Ð´Ñ ÑÐµÐ¾ÑÐµÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð¸ Ð¿ÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÐ°ÑÑÐµÐ¹ ÑÐ°Ð±Ð¾ÑÑ.
Dynamical horizon entropy and equilibrium thermodynamics of generalized gravity theories
Creators: name: Wu, Shao-Feng
name: Ge, Xian-Hui
name: Zhang, Peng-Ming
name: Yang, Guo-Hong
Publisher: name: arXiv
Year: 2009
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We study the relation between the thermodynamics and field equations of generalized gravity theories on the dynamical trapping horizon with sphere symmetry. We assume the entropy of dynamical horizon as the Noether charge associated with the Kodama vector and point out that it satisfies the second law when a Gibbs equation holds. We generalize two kinds of Gibbs equations to Gauss-Bonnet gravity on any trapping horizon. Based on the quasi-local gravitational energy found recently for $f(R)$ gravity and scalar-tensor gravity in some special cases, we also build up the Gibbs equations, where the nonequilibrium entropy production, which is usually invoked to balance the energy conservation, is just absorbed into the modified Wald entropy in the FRW spacetime with slowly varying horizon. Moreover, the equilibrium thermodynamic identity remains valid for $f(R)$ gravity in a static spacetime. Our work provides an alternative treatment to reinterpret the nonequilibrium correction and supports the idea that the horizon thermodynamics is universal for generalized gravity theories.
description: 23 pages, no figure, minor changes, accepted for publication in Phys. Rev. D
title: ÐÐ¸ÐºÑÐ¾-ÐÐ­Ð¡ â Ð°Ð²ÑÐ¾Ð½Ð¾Ð¼Ð½ÑÐ¹ Ð¸ÑÑÐ¾ÑÐ½Ð¸Ðº ÑÐ½ÐµÑÐ³Ð¸Ð¸
title: Micro HPP â autonomous energy source
Creators: name: ÐÐ¸Ð¼Ð½Ð¸ÑÐºÐ¸Ð¹, ÐÐ»Ð°Ð´Ð¸Ð¼Ð¸Ñ
name: ÐÐ¸Ð¼Ð½Ð¸ÑÐºÐ¸Ð¹, ÐÐ»ÐµÐºÑÐµÐ¹
name: ÐÐ¸Ð¼Ð½Ð¸ÑÐºÐ°Ñ, ÐÐ¾Ñ
name: "ÐÐ¸Ð´ÑÐ°Ð²Ð»Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¼Ð°ÑÐ¸Ð½Ñ, Ð³Ð¸Ð´ÑÐ¾Ð¿ÑÐ¸Ð²Ð¾Ð´Ñ Ð¸ Ð³Ð¸Ð´ÑÐ¾Ð¿Ð½ÐµÐ²Ð¼Ð¾Ð°Ð²ÑÐ¾Ð¼Ð°ÑÐ¸ÐºÐ°. Ð¡Ð¾Ð²ÑÐµÐ¼ÐµÐ½Ð½Ð¾Ðµ ÑÐ¾ÑÑÐ¾ÑÐ½Ð¸Ðµ Ð¸ Ð¿ÐµÑÑÐ¿ÐµÐºÑÐ¸Ð²Ñ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ", Ð¼ÐµÐ¶Ð´ÑÐ½Ð°ÑÐ¾Ð´Ð½Ð°Ñ Ð½Ð°ÑÑÐ½Ð¾-ÑÐµÑ Ð½Ð¸ÑÐµÑÐºÐ°Ñ ÐºÐ¾Ð½ÑÐµÑÐµÐ½ÑÐ¸Ñ (2020; Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³)
Publisher: name: ÐÐÐÐÐ¢ÐÐ¥-ÐÐ ÐÐ¡Ð¡
Year: 2020
Subjects: Ð­Ð»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ°Ñ ÑÐ½ÐµÑÐ³Ð¸Ñ
ÐÐ¸Ð´ÑÐ¾ÑÑÑÐ±Ð¸Ð½Ñ

description: Ð ÑÑÐ°ÑÑÐµ Ð¿ÑÐ¸Ð²ÐµÐ´ÐµÐ½Ñ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ¾Ðº Ð¸ Ð¸ÑÐ¿ÑÑÐ°Ð½Ð¸Ð¹ Ð²Ð°ÑÐ¸Ð°Ð½ÑÐ° Ð³Ð¸Ð´ÑÐ¾ÑÐ½ÐµÑÐ³ÐµÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÑÑÐ°Ð½Ð¾Ð²ÐºÐ¸ (ÐÐ¸ÐºÑÐ¾ ÐÐ­Ð¡) Ð¼Ð¾ÑÐ½Ð¾ÑÑÑÑ 1 ÐºÐÑ. ÐÑÐ¸Ð²ÐµÐ´ÐµÐ½Ñ ÑÐµÐºÐ¾Ð¼ÐµÐ½Ð´Ð°ÑÐ¸Ð¸ Ð¿Ð¾ ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ñ ÐÐÐ­Ð¡ Ð¼Ð¾ÑÐ½Ð¾ÑÑÑÑ 1â5 ÐºÐÑ.
description: The paper presents the results of development and testing of the hydropower plant variant (Micro HPP) with the capacity of 1 kW. Recommendations on creation of MHPP with capacity of 1â5 kW are given.
Orbital migration of low-mass planets in evolutionary radiative models: Avoiding catastrophic infall
Creators: name: Lyra, W.
name: Paardekooper, S. -J.
name: Mac Low, M. -M.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Outward migration of low-mass planets has recently been shown to be a possibility in non-barotropic disks. We examine the consequences of this result in evolutionary models of protoplanetary disks. Planet migration occurs towards equilibrium radii with zero torque. These radii themselves migrate inwards because of viscous accretion and photoevaporation. We show that as the surface density and temperature fall, the planet orbital migration and disk depletion timescales eventually become comparable, with the precise timing depending on the mass of the planet. When this occurs, the planet decouples from the equilibrium radius. At this time, however, the gas surface density is already too low to drive substantial further migration. A higher mass planet, of 10 Earth masses, can open a gap during the late evolution of the disk, and stops migrating. Low mass planets, with 1 or 0.1 Earth masses, released beyond 1 AU in our models, avoid migrating into the star. Our results provide support for the reduced migration rates adopted in recent planet population synthesis models.
description: 6 pages, 4 figures. Accepted by ApJ. In press.
title: ÐÐ°ÑÐºÐ°ÑÐ½Ð¾Ðµ Ð·Ð´Ð°Ð½Ð¸Ðµ Ñ Ð¼Ð½Ð¾Ð³Ð¾ÑÐ»Ð¾Ð¹Ð½ÑÐ¼ ÑÑÐµÐ½Ð¾Ð²ÑÐ¼ Ð¾Ð³ÑÐ°Ð¶Ð´ÐµÐ½Ð¸ÐµÐ¼
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
Creators: name: Ð¡ÑÑÐºÐ¾Ð², ÐÐ¸ÐºÐ¸ÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2018
Subjects: Ð¾Ð±ÑÐµÑÑÐ²ÐµÐ½Ð½Ð¾Ðµ Ð·Ð´Ð°Ð½Ð¸Ðµ
Ð¼Ð½Ð¾Ð³Ð¾ÑÐ»Ð¾Ð¹Ð½Ð¾Ðµ Ð¾Ð³ÑÐ°Ð¶Ð´ÐµÐ½Ð¸Ðµ
ÐºÐ¸ÑÐ¿Ð¸ÑÐ½Ð°Ñ ÐºÐ»Ð°Ð´ÐºÐ°

description: Ð¡Ð¸ÑÑÐµÐ¼Ñ ÑÐ»Ð¾Ð¸ÑÑÐ¾Ð¹ ÐºÐ»Ð°Ð´ÐºÐ¸ Ð²ÐµÐ½ÑÐ¸Ð»Ð¸ÑÑÐµÐ¼ÑÑ ÑÐ°ÑÐ°Ð´Ð¾Ð² Ð² Ð½Ð°ÑÑÐ¾ÑÑÐµÐµ Ð²ÑÐµÐ¼Ñ Ð½Ð°ÑÐ¾Ð´ÑÑ ÑÐ¸ÑÐ¾ÐºÐ¾Ðµ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ðµ Ð² ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÐ½Ð¾Ð¹ Ð¾ÑÑÐ¾ÑÐ»Ð¸. Ð¢Ð°ÐºÐ¸Ðµ ÑÐ¸ÑÑÐµÐ¼Ñ Ð¿ÑÐ¸Ð¼ÐµÐ½ÑÑÑÑÑ Ð´Ð»Ñ Ð½Ð¾Ð²Ð¾Ð³Ð¾ ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÑÑÐ²Ð° Ð¶Ð¸Ð»ÑÑ, Ð¾Ð±ÑÐµÑÑÐ²ÐµÐ½Ð½ÑÑ Ð¸ Ð°Ð´Ð¼Ð¸Ð½Ð¸ÑÑÑÐ°ÑÐ¸Ð²Ð½ÑÑ Ð·Ð´Ð°Ð½Ð¸Ð¹. ÐÐ¾ÑÑÑÐµÐ±Ð¾Ð²Ð°Ð½Ð½Ð¾ÑÑÑ Ð´Ð°Ð½Ð½ÑÑ ÑÐ¸ÑÑÐµÐ¼ Ð¾Ð±ÑÑÑÐ½ÑÐµÑÑÑ Ð¸Ñ Ð¼Ð½Ð¾Ð³Ð¾ÑÑÐ½ÐºÑÐ¸Ð¾Ð½Ð°Ð»ÑÐ½Ð¾ÑÑÑÑ: ÑÐ¸ÑÑÐµÐ¼Ñ ÑÐ»Ð¾Ð¸ÑÑÐ¾Ð¹ ÐºÐ»Ð°Ð´ÐºÐ¸ Ð²ÐµÐ½ÑÐ¸Ð»Ð¸ÑÑÐµÐ¼ÑÑ ÑÐ°ÑÐ°Ð´Ð¾Ð² Ð½Ðµ ÑÐ¾Ð»ÑÐºÐ¾ Ð¿ÑÐ¸Ð´Ð°ÑÑ Ð·Ð´Ð°Ð½Ð¸Ñ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð½ÑÐ¹ Ð°ÑÑÐ¸ÑÐµÐºÑÑÑÐ½ÑÐ¹ Ð¾Ð±Ð»Ð¸Ðº, Ð½Ð¾ Ð¸ Ð²ÑÐ¿Ð¾Ð»Ð½ÑÑÑ ÑÐµÐ¿Ð»Ð¾Ð·Ð°ÑÐ¸ÑÐ½ÑÐµ ÑÑÐ½ÐºÑÐ¸Ð¸, ÑÐ¿Ð¾ÑÐ¾Ð±ÑÑÐ²ÑÑÑ Ð½Ð¾ÑÐ¼Ð°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ ÑÐµÐ¿Ð»Ð¾Ð²Ð»Ð°Ð¶Ð½Ð¾ÑÑÐ½Ð¾Ð³Ð¾ ÑÐµÐ¶Ð¸Ð¼Ð° Ð·Ð´Ð°Ð½Ð¸Ñ, ÑÑÐ¾ Ð´Ð¾ÑÑÐ¸Ð³Ð°ÐµÑÑÑ Ð±Ð»Ð°Ð³Ð¾Ð´Ð°ÑÑ ÐºÐ¾Ð½ÑÑÑÑÐºÑÐ¸Ð¸ Ð´Ð°Ð½Ð½ÑÑ ÑÐ¸ÑÑÐµÐ¼.
Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ Ð²ÑÐ¿ÑÑÐºÐ½Ð¾Ð¹ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð¾Ð±Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ñ Ð´Ð¾Ð¿ÑÑÑÐ¸Ð¼ÑÐµ ÑÐ°ÑÑÑÐ¾ÑÐ½Ð¸Ñ Ð¼ÐµÐ¶Ð´Ñ ÑÐµÐ¼Ð¿ÐµÑÐ°ÑÑÑÐ½Ð¾-Ð´ÐµÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½ÑÐ¼Ð¸ ÑÐ²Ð°Ð¼Ð¸ Ð² Ð»Ð¸ÑÐµÐ²Ð¾Ð¼ ÑÐ»Ð¾Ðµ Ð¼Ð½Ð¾Ð³Ð¾ÑÐ»Ð¾Ð¹Ð½Ð¾Ð¹ Ð¾Ð³ÑÐ°Ð¶Ð´Ð°ÑÑÐµÐ¹ ÐºÐ¾Ð½ÑÑÑÑÐºÑÐ¸Ð¸.
High Albedos of Low Inclination Classical Kuiper Belt Objects
Creators: name: Brucker, M. J.
name: Grundy, W. M.
name: Stansberry, J. A.
name: Spencer, J. R.
name: Sheppard, S. S.
name: Chiang, E. I.
name: Buie, M. W.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present observations of thermal emission from fifteen transneptunian objects (TNOs) made using the Spitzer Space Telescope. Thirteen of the targets are members of the Classical population: six dynamically hot Classicals, five dynamically cold Classicals, and two dynamically cold inner Classical Kuiper Belt Objects (KBOs). We fit our observations using thermal models to determine the sizes and albedos of our targets finding that the cold Classical TNOs have distinctly higher visual albedos than the hot Classicals and other TNO dynamical classes. The cold Classicals are known to be distinct from other TNOs in terms of their color distribution, size distribution, and binarity fraction. The Classical objects in our sample all have red colors yet they show a diversity of albedos which suggests that there is not a simple relationship between albedo and color. As a consequence of high albedos, the mass estimate of the cold Classical Kuiper Belt is reduced from approximately 0.01 Earth masses to approximately 0.001 Earth masses. Our results also increase significantly the sample of small Classical KBOs with known albedos and sizes from 21 to 32 such objects.
description: In press, Icarus 26 pages, 4 figures, 6 tables Replaced Fig. 4 with correct axis labels
Vainu Bappu Memorial Lecture: What is a sunspot?
Creators: name: Gough, D. O.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Sunspots have been known in the West since Galileo Galilei and Thomas Harriot first used telescopes to observe the Sun nearly four centuries ago; they have been known to the Chinese for more than two thousand years. They appear as relatively dark patches on the surface of the Sun, and are caused by concentrations of magnetism which impede the flow of heat from deep inside the Sun up to its othewise brilliant surface. The spots are not permanent: the total number of spots on the Sun varies cyclically in time, with a period of about eleven years, associated with which there appear to be variations in our climate. When there are many spots, it is more dangerous for spacecraft to operate. The cause of the spots is not well understood; nor is it known for sure how they die. Their structure beneath the surface of the Sun is in some dispute, although much is known about their properties at the surface, including an outward material flow which was discovered by John Evershed observing the Sun from Kodaikanal a hundred years ago. I shall give you a glimpse of how we are striving to deepen our understanding of these fascinating features, and of some of the phenomena that appear to be associated with them.
description: Lecture delivered at the Indian Institute of Astrophysics, December 2008 Typing errors corrected To appear in Magnetic Coupling between the Interior and the Atmosphere of the Sun, ed. S.S. Hasan & R.J. Rutten, Astr. Sp. Sci. Proc
Mobility induces global synchronization of oscillators in periodic extended systems
Creators: name: Peruani, Fernando
name: Nicola, Ernesto M.
name: Morelli, Luis G.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: We study synchronization of locally coupled noisy phase oscillators which move diffusively in a one-dimensional ring. Together with the disordered and the globally synchronized states, the system also exhibits several wave-like states which display local order. We use a statistical description valid for a large number of oscillators to show that for any finite system there is a critical spatial diffusion above which all wave-like solutions become unstable. Through Langevin simulations, we show that the transition to global synchronization is mediated by the relative size of attractor basins associated to wave-like states. Spatial diffusion disrupts these states and paves the way for the system to attain global synchronization.
title: Electroceramics XVII - The 2020 virtual conference experience at TU Darmstadt
Creators: name: Koruza, Jurij
name: Klein, Andreas
name: Huart, Véronique
name: Bagnoli, Jessica
Publisher: name: Elsevier
Year: 2021

description: The Electroceramics XVII conference, held August 24–28, 2020, was the first fully online conference in the biannual Electroceramics conference series. This communication provides a summary of the experiences gathered during the organization and execution of the meeting. Besides discussing the various pros and cons, we also aim to provide basic guidelines for scientific online conferencing, which will hopefully encourage individual readers to consider virtual meetings as an alternative or a supplement to in-person events, even after the COVID-19 pandemic.