Interethnic analyses of blood pressure loci in populations of East Asian and European descent
Creators: name: Saw, Woei-Yuh
name: Huo, Shaofeng
name: Isono, Masato
name: Li, Huaixing
name: Sabanayagam, Charumathi
name: He, Jiang
name: Huang, Wei
name: Narita, Akira
name: Hwang, Mi Yeong
name: Chambers, John C.
name: Sun, Liang
name: Nakatochi, Masahiro
name: Kelly, Tanika N.
name: Tai, E-Shyong
name: Momozawa, Yukihide
name: Adair, Linda S.
name: Miki, Tetsuro
name: Spracklen, Cassandra N.
name: Clarke, Robert
name: Han, Sohee
name: Wu, Jer-Yuarn
name: Lin, Xu
name: Chang, Li-Ching
name: Wong, Tien Yin
name: Wang, Chaolong
name: Kooner, Jaspal S.
name: Nakashima, Eitaro
name: Zhang, Liang
name: Koh, Woon-Puay
name: Dorajoo, Rajkumar
name: Hozawa, Atsushi
name: Matsubara, Tatsuaki
name: Li, Liming
name: van der Harst, Pim
name: Kim, Bong-Jo
name: Matsuda, Koichi
name: Chen, Chien-Hsiun
name: Li, Honglan
name: Friedlander, Yechiel
name: Nierenberg, Jovia L.
name: Kubo, Michiaki
name: Ichihara, Sahoko
name: Kohara, Katsuhiko
name: Cheng, Ching-Yu
name: Mohlke, Karen L.
name: Shirota, Matsuyuki
name: Chen, Yuan-Tsong
name: Yuan, Jian-Min
name: Chen, Zhengming
name: Rakugi, Hiromi
name: He, Jing
name: Lin, Kuang
name: Kamatani, Yoichiro
name: Yamamoto, Ken
name: Sasaki, Makoto
name: Elliott, Paul
name: Igase, Michiya
name: Nabika, Toru
name: Hirata, Makoto
name: Walters, Robin G.
name: Akiyama, Masato
name: Yamamoto, Masayuki
name: Zheng, Wei
name: Xiang, Yong-Bing
name: Katsuya, Tomohiro
name: Bennett, Derrick A.
name: Xu, Liang
name: Edwards, Todd L.
name: Shu, Xiao-Ou
name: Moon, Sanghoon
name: Zhao, Wanting
name: Heng, Chew-Kiat
name: Lee, Juyoung
name: Millwood, Iona Y.
name: Wang, Ya Xing
name: Yokota, Mitsuhiro
name: Bin Wei, Wen
name: Jonas, Jost B.
name: Takeuchi, Fumihiko
name: Tabara, Yasuharu
name: Gordon-Larsen, Penny
name: Kato, Norihiro
name: Kim, Young-Jin
name: Long, Jirong
name: Reilly, Dermot F.
name: Chai, Jin-Fang
name: Liu, Jianjun
name: Cai, Hui
name: Matoba, Nana
name: Teo, Yik-Ying
name: Sim, Xueling
name: Takahashi, Atsushi
name: Chee, Miao Li
name: Lee, Nanette R.
Publisher: name: Springer Nature
Year: 2018

description: <p>Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N&thinsp;=&thinsp;289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.</p>