cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
BENEFITSIAR MULKNING SAMARALI BOSHQARILISHIDA FIDUSIAR MAJBURIYATLARNING AHAMIYATI
Creators: name: Raximova, Dilorom
Publisher: name: Zenodo
Year: 2025

description: Fidusiar majburiyatlar asosan halollik, sodiqlik, g‘amxo‘rlik va oqilona boshqaruv tamoyillari asosida benefitsiar mulkdor manfaatlarini himoya qilishga qaratiladi. Mazkur maqolada zamonaviy huquq tizimlarida Benefitsiar mulkni boshqarishda fidusiar munosabatlarning ahamiyati, fidusiar majburiyatlarning shakllanishi va ularning huquqiy munosabatlarni ta’minlashdagi ahamiyati hamda milliy qonunchilikdagi holati tahlil etilib, ushbu sohadagi huquqiy bo‘shliqlar va ularni bartaraf etish zarurati asoslab berilgan. Shu bilan birga milliy qonunchilikda fidusiar va benefitsiar o‘rtasidagi huquq va majburiyatlarni aniq belgilovchi normativ-huquqiy asoslarning yo‘qligi tanqidiy ko‘rib chiqilib, milliy qonunchilikni takomillashtirish yuzasidan takliflarni ishlab chiqilgan. Bundan tashqari, xalqaro tajribadan kelib chiqib, fidusiar munosabatlarni huquqiy jihatdan mustahkamlash orqali benefitsiar mulkning samarali boshqarilishini ta’minlashning huquqiy asoslari shakllantirilishi lozimligi ta’kidlangan.
Labour inclusion of LGBTI people in Spain: Ethics and conduct codes
Creators: name: Rivera Martín, Beatriz
name: Martínez De Bartolomé, Ireide
Publisher: name: Ramon Llull Journal of Applied Ethics
Year: 2022

description: Abstract: The company is a social agent that contributes to the integration of people in their working and social environment. Through codes of conduct, companies set out their values and ethics with the aim of guiding coexistence among the members of the corporation and, at the same time, projecting a certain external image. As argued, LGBTI people continue to suffer discrimination at work in Spain, and a high percentage of them decide to hide their sexual orientation or gender identity to avoid being excluded, which means that they do not find in their workplaces the ideal environment to feel integrated. As discussed in the theoretical framework, the willingness of governments to establish a regulatory framework for the protection of LGBTI people is not enough. Although governments are the main guarantors of the enforcement of human rights, companies have an ethical responsibility to ensure the protection of their workers in the workplace, as stated in the Universal Declaration of Human Rights, as well as contributing to social change. In short, companies should promote working conditions that avoid discrimination on the grounds of sexual orientation and gender identity and/or expression, and at the same time they should establish specific procedures for its prevention and for dealing with complaints that may be made by those who have been subjected to it. To this end, measures such as codes of conduct can be put in place. The codes of conduct of the Ibex35 companies have been analysed to reveal whether they recognise LGBTI people and in which terms. Without wishing to anticipate the final conclusions, readers are warned that they will find relevant data, and that there is still a long way to achieve the effective inclusion of LGBTI people and their different forms.
description: Ramon Llull Journal of Applied Ethics, Vol. 1, Núm. 13 (2022): Issue 13
Measuring Engagement in Strategic Clinical Networks in Alberta: A Theory of Planned Behaviour Study
Creators: name: Rabatach, Leora
Publisher: name: Graduate Studies
Year: 2017
Subjects: subject: Health Care Management
subject: Statistics
subject: FOS: Mathematics
subject: Psychology--Behavioral
subject: Psychometrics
subject: Theory of Planned Behaviour
subject: Engagement
subject: Organizational Change
subject: Behavioural theory
subject: Health Systems
subject: Clinical Networks
subject: Quality Improvement

description: Worldwide, Strategic Clinical Networks (SCNs) are primary structures to improve patient safety, quality of care, and evidence-based healthcare practices. Stakeholder engagement plays a key role in quality improvement (QI) initiatives within SCNs. However, little is known about what factors affect engagement within SCNs. Using the Theory of Planned Behaviour (TPB) as a framework, this study aimed to assess factors that predict stakeholders’ intent to engage in SCN QI projects. Survey questions were developed using the TPB constructs intention, attitude, subjective norms, descriptive norms, and perceived behavioural control. Nine SCNs participated in the study (23% - response rate). Score validity evidence was established through content, internal structure (reliability), and relationships between variables (exploratory factor analysis and multiple regression). Results provide preliminary evidence for the utility of the tool to measure engagement. Additionally, interventions targeted at enhancing stakeholder attitudes and subjective norms could increase engagement in SCN project work in the future.
What Drives Task Performance During Animal Fluency in People With Alzheimer’s Disease?
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2020
Subjects: fluency
category
animal
switches
clusters
age of acquisition

description: © Copyright © 2020 Rofes, de Aguiar, Jonkers, Oh, DeDe and Sung. Background: Animal fluency is a widely used task to assess people with Alzheimer’s disease (AD) and other neurological disorders. The mechanisms that drive performance in this task are argued to rely on language and executive functions. However, there is little information regarding what specific aspects of these cognitive processes drive performance on this task. Objective: To understand which aspects of language (i.e., semantics, phonological output lexicon, phonological assembly) and executive function (i.e., mental set shifting; information updating and monitoring; inhibition of possible responses) are involved in the performance of animal fluency in people with AD. Methods: Animal fluency data from 58 people with probable AD from the DementiaBank Pittsburgh Corpus were analyzed. Number of clusters and switches were measured and nine word properties (e.g., frequency, familiarity) for each of the correct words (i.e., each word counting toward the total score, disregarding non-animals and repetitions) were determined. Random forests were used to understand which variables predicted the total number of correct words, and conditional inference trees were used to search for interactions between the variables. Finally, Wilcoxon tests were implemented to cross-validate the results, by comparing the performance of participants with scores below the norm in animal fluency against participants with scores within the norm based on a large normative sample. Results: Switches and age of acquisition emerged as the most important variables to predict total number of correct words in animal fluency in people with AD. Cross-validating the results, people with AD whose animal fluency scores fell below the norm produced fewer switches and words with lower age of acquisition than people with AD with scores in the normal range. Conclusion: The results indicate that people with AD rely on executive functioning (information updating and monitoring) and language (phonological output lexicon, not necessarily semantics) to produce words on animal fluency.
The SDSS-II Supernova Survey: Parameterizing the Type Ia Supernova Rate as a Function of Host Galaxy Properties
Creators: name: Smith, Mathew
name: Nichol, Robert C
name: Dilday, Benjamin
name: Marriner, John
name: Kessler, Richard
name: Bassett, Bruce
name: Cinabro, David
name: Frieman, Joshua
name: Garnavich, Peter
name: Jha, Saurabh W
name: Lampeitl, Hubert
name: Sako, Masao
name: Schneider, Donald P
name: Sollerman, Jesper
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Using data from the Sloan Digital Sky Supernova Survey-II, we measure the rate of Type Ia Supernovae (SNe Ia) as a function of galaxy properties at intermediate redshift. A sample of 342 SNe Ia with 0.05
description: 46 pages, submitted to ApJ
The Free2B Multi-Media Bullying Prevention Experience: An Exemplar of Scientific Edutainment
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2020
Subjects: bullying
community-based participatory research
edutainment
prevention
school-based
scientific edutainment

description: © Copyright © 2020 Leff, Waasdorp, Paskewich, Bevans and Winston. Objective: The objective of the current article is to highlight an example of a new paradigm, Scientific Edutainment. The manuscript describes how educational researchers and technologists worked together to develop a multi-media bullying prevention experience, called Free2B for middle school students paying particular attention to ensure that the programming was not only relevant to all students but also was appealing and responsive to the needs of urban youth. Bullying is the most common form of aggression experienced among school-aged youth, which impairs students’ learning and social-emotional functioning and has financial costs to society. Given that the prevalence of bullying is highest in middle school, finding brief and feasible methods for motivating and sustaining change at this age is critically important, especially in the case of urban, under-resourced schools. Method: In response to this challenge, multidisciplinary bullying prevention researchers collaborated with international technologists to develop the Free2B multi-media bullying prevention experience through an iterative Community-Based Participatory Research (CBPR) approach. In addition, the research team conducted a series of pilot studies to iteratively develop and initially evaluate the multi-media program, helping to ensure relevance specifically for urban middle school youth. Results: Results from the pilot studies indicated that the vast majority of middle school students found the Free2B multi-media bullying prevention experience to be enjoyable, relevant to their needs, and addressed important strategies to handle peer bullying and victimization. In addition, the brief prevention experience was associated with increases in problem-solving knowledge, prosocial attitudes about bullying, increased sympathy, and confidence in handling peer conflicts. Conclusion: The current paper illustrates the use of a new paradigm, termed Scientific Edutainment, as a way to combine evidenced-based developmental science with the latest in entertainment technology to provide innovative, engaging, and technologically-sophisticated educational programming.
Design and analysis of capacitive micromachined ultrasound transducer
Creators: name: Motieian Najar, Mohammad Hadi
Publisher: name: University of British Columbia
Year: 2010

description: Capacitive Micromachined Ultrasound Transducers (CMUTs) have been recently introduced as a viable substitute to piezoelectric transducers in medical ultrasound imaging. CMUT possesses advantages such as allowing high frequency, having wide bandwidth, high sensitivity, low cost, CMOS compatibility and being easy to fabricate. This thesis is motivated by movement towards a better detection of breast tumors using ultrasound imaging techniques, which CMUTs have promised to achieve. Therefore, CMUTs were designed to fulfill requirements of this application in terms of resonant frequency, pull-in voltage and geometrical dimensions. The entire design and analysis were performed considering that the CMUTs are to be fabricated using PolyMUMPs technology, for this technology being precise, accurate and well established in the micro-electromechanical systems (MEMS) community. CMUTs were first analytically modeled and designed by exploiting the parallel-plate capacitor equations. A behavioral model was developed in VHDL-AMS, which, unlike previous models, incorporates the non-linear electromechanical relations of the CMUT. The behavioral model has the advantage of being more time efficient than finite element models (FEM) and more accurate than analytical models. Prior to fabrication, a 3D FEM was developed in COMSOL Multiphysics® software. Resonant frequency analysis determined the frequency response and eigenfrequencies of the CMUT, which could not be determined using previous models. Parametric analysis determined the pull-in voltage, the spring constant and spring softening effect, the variation in capacitance and the electromechanical efficiency of the CMUT. The CMUT resonated at 5.868MHz frequency and the collapse voltage was determined at 275V using FEM results, which were close to analytical modeling results and in excellent agreement with behavioral modeling results. The thickness and the radius of the circular CMUT membrane were found to be 1.5μm and 32μm, respectively. The air/vacuum gap distance was 0.75μm and the insulation layer was 0.6μm. The CMUTs were fabricated in cell and array form. An array of 128 elements each containing 118 cells were fabricated to be compatible with existing ultrasound probes. Unfortunately, due to mal-fabrication by the company, which was experimentally proved, the experimental results were not as successful.
Open-Ended Explorations in Exhibition Spaces: A Case for Information Visualization and Large Direct-Touch Displays
Creators: name: Hinrichs, Uta
Publisher: name: Graduate Studies
Year: 2013
Subjects: subject: Computer Science
subject: Large Interactive Displays
subject: information visualization
subject: Art Installation
subject: Museum Exhibits
subject: Field Studies
subject: Direct-touch Interaction
subject: Multi-touch Gestures

description: Large interactive displays have become more commonplace in museums, libraries, and art galleries. Their interactive capabilities and size offer opportunities to present information to visitors in an engaging yet informative way. However, the characteristics of exhibition spaces, such as diverse audiences, brief interaction times, and self-guided exploration styles present challenges to the design of such exhibits. In this doctoral thesis, I present four case studies that investigate how open-ended exploration can be promoted using visualization-based large display exhibits, how shared interactions with such exhibits can be characterized, and how multi-touch capabilities influence interactions in exhibition spaces. Case Study I, memory [en]code, touches upon the concepts of serendipity and participation as different ways to promote engagement with information via direct-touch displays. Case Study II, EMDialog, investigates how museum visitors experience interactive information visualizations as part of an exhibition of traditional paintings. Case Study III, the Bohemian Bookshelf, explores how serendipitous discoveries can be promoted by combining information visualization with large display exhibits in the context of library book collections. In Case Study IV, I investigate visitor interactions with two multi-touch tabletop exhibits. I focus on how the interface design influences individual and collaborative exploration strategies, and I explore the role of multi-touch gestures as part in open-ended exploration. My research contributes to the areas of information visualization, museum studies, and interactive surfaces on a design and empirical level. I introduce the idea of promoting open-ended exploration in exhibition spaces by combining information visualization with large display technology. I provide a new perspective on serendipity, as one important aspect of open-ended information exploration. I show how visitors experience and interact with large display exhibits. In particular, I contribute a detailed characterization of collaborative activities that evolve around visualization-based exhibits. Furthermore, I provide insights on how multi-touch gestures are applied around large display exhibits. On a methodological level, my field studies expand on qualitative methods in the context of real-world study settings. The four case studies as a whole show how visitor expectations toward large display exhibits have changed across the years and provide a glimpse into future research directions.
Where Did SARS-CoV-2 Come From?
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2020
Subjects: origins
evolution
pandemic
SARS-CoV-2

description: © The Author(s) 2020. Identifying the origin of SARS-CoV-2, the etiological agent of the current COVID-19 pandemic, may help us to avoid future epidemics of coronavirus and other zoonoses. Several theories about the zoonotic origin of SARS-CoV-2 have recently been proposed. Although Betacoronavirus found in Rhinolophus bats from China have been broadly implicated, their genetic dissimilarity to SARS-CoV-2 is so high that they are highly unlikely to be its direct ancestors. Thus, an intermediary host is suspected to link bat to human coronaviruses. Based on genomic CpG dinucleotide patterns in different coronaviruses from different hosts, it was suggested that SARS-CoV-2 might have evolved in a canid gastrointestinal tract prior to transmission to humans. However, similar CpG patterns are now reported in coronaviruses from other hosts, including bats themselves and pangolins. Therefore, reduced genomic CpG alone is not a highly predictive biomarker, suggesting a need for additional biomarkers to reveal intermediate hosts or tissues. The hunt for the zoonotic origin of SARS-CoV-2 continues.
Unproductive effects of alk gene amplification and copy number gain in non-small-cell lung cancer. Alk gene amplification and copy gain in nsclc
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2020
Subjects: ALK
amplification
copy number gain
non-small-cell lung cancer

description: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Background: The Anaplastic Lymphoma Kinase (ALK) gene is known to be affected by several genetic alterations, such as rearrangement, amplification and point mutation. The main goal of this study was to comprehensively analyze ALK amplification (ALK-A) and ALK gene copy number gain (ALK-CNG) in a large cohort of non-small-cell lung cancer (NSCLC) patients in order to evaluate the effects on mRNA and protein expression. Methods: ALK locus number status was evaluated in 578 NSCLC cases by fluorescence in situ hybridization (FISH). In addition, ALK immunohistochemistry and ALK mRNA in situ hybridization were performed. Results: Out of 578 cases, 17 cases showed ALK-A. In addition, 14 cases presented ALK-CNG and 72 cases presented chromosome 2 polyploidy. None of those carrying ALK-A and-CNG showed either ALK immunohistochemical expression or ALK mRNA expression through in situ hybridization. We observed a high frequency of extra copies of the ALK gene. Conclusions: Our findings demonstrated that ALK-A is not involved in mRNA production and consequently is not involved in protein production; these findings support the hypothesis that ALK-A might not play a role in the pathogenesis of NSCLC, underlining the absence of a specific clinical application.
Full counting statistics of Kondo-type tunneling in a quantum dot: the fluctuation effect of Slave-Boson field
Creators: name: Dong, Bing
name: Ding, G. H.
name: Lei, X. L.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study the full counting statistics (FCS) of electron tunneling through a multi-terminal quantum dot in the Kondo regime within the slave-boson mean field theory. By employing the A.O. Gogolin and A. Komnik's method of calculating the FCS generating function based on the nonequilibrium Green's function [Phys. Rev. B {\bf 73}, 195301 (2006)], we obtain the counting field $λ$-dependent self-consistent equations for the mean values of the slave-boson fields and the explicit expression for the derivative of the adiabatic potential of the system with respect to the counting fields. Performing perturbative expansion to the first order of $λ$, we find an extra contribution to the shot noise due to the bias-induced Bose field fluctuation, and then confirm that the nonequilibrium particle number fluctuation plays an important role in the current noise of the Kondo dot: enhancement of the current auto-correlation and a positive current cross-correlation.
description: 11 pages, 3 figures, to be published
A Study in Hybrid Monte Carlo Methods in Computing Derivative Prices
Creators: name: Wang, Binbin
Publisher: name: Graduate Studies
Year: 2012
Subjects: subject: Economics--Finance
subject: Mathematics
subject: FOS: Mathematics
subject: Hybrid Monte Carlo
subject: Financial derivatives
subject: Monte Carlo
subject: Efficiency
subject: Variance Reduction
subject: Basket options

description: Hybrid Monte Carlo (HMC) method is defined in this thesis as Monte Carlo method that utilizes conditional expectation so that the regular Monte Carlo method and other computational methods can be combined to price financial derivatives. This thesis introduces several hybrid Monte Carlo methods and studies the algorithm and efficiency of these methods, which include three methods combining Monte Carlo with fast Fourier transform, cosine series, and Black-Scholes formula respectively. These methods can be considered as ways of variance reduction. The thesis also introduces a new variance reduction method using orthogonal transformation which further reduces the variance. It is shown in this thesis that the HMC methods can significantly improve the efficiency when compared to the regular Monte Carlo method. A basket option example is used throughout this thesis for implementation and efficiency comparison.
Large rare fluctuations in systems with delayed dissipation
Creators: name: Dykman, M. I.
name: Schwartz, I. B.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study the probability distribution and the escape rate in systems with delayed dissipation that comes from the coupling to a thermal bath. To logarithmic accuracy in the fluctuation intensity, the problem is reduced to a variational problem. It describes the most probable fluctuational paths, which are given by acausal equations due to the delay. In thermal equilibrium, the most probable path passing through a remote state has time reversal symmetry, even though one cannot uniquely define a path that starts from a state with given system coordinate and momentum. The corrections to the distribution and the escape activation energy for small delay and small noise correlation time are obtained in the explicit form.
description: 9 pages
Past buoy lines : an arts-based inquiry into living and knowing giftedness
Creators: name: Richardson, Pamela
Publisher: name: University of British Columbia
Year: 2010

description: In this dissertation, I articulate an approach to knowing and living giftedness based in arts-based educational inquiry practices (Barone & Eisner, 1997; Knowles & Cole, 2008; Springgay, Irwin, Leggo & Gouzouasis, 2009). This work represents aspects of a four-year inquiry based in poetic and narrative writing (Leggo, 2005; 2008), during which I facilitated community development projects with radically early entrants to university (adolescents who entered university at 14 or 15). Here I expand upon methodological approaches to research in the field of Gifted Education and challenge categorical definitions of giftedness. Through a series of artful inquiries, including poetry, narrative, autobiography, biography, literary analysis, digital storytelling and field research, I model intrinsically relational, emotional and situated ways of relating to gifts as a researcher and educator. Woven through these inquiries are the themes of poetry, polyphony, fluidity and freedom. These are explored as aesthetic practices underlying an arts-based understanding of giftedness.
Eif4g1 and ran as possible drivers for malignant pleural mesothelioma
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2020
Subjects: cancer driving gene
MPM
RAN
siRNA
importazole

description: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. For malignant pleural mesothelioma (MPM) novel therapeutic strategies are urgently needed. In a previous study, we identiﬁed 51 putative cancer genes over-expressed in MPM tissues andcelllines. Here,wedeepenedthestudyonnineofthem(ASS1,EIF4G1,GALNT7,GLUT1,IGF2BP3 (IMP3),ITGA4,RAN,SOD1,andTHBS2)to ascertain whether they are truly mesothelial cancer driver genes(CDGs) or genes overexpressed in an adaptive response to the tumoral progression(“passenger genes”). Through a fast siRNA-based screening, we evaluated the consequences of gene depletion on migration, proliferation, colony formation capabilities, and caspase activities of four MPM (Mero-14, Mero-25, IST-Mes2, and NCI-H28) and one SV40-immortalized mesothelial cell line (MeT-5A) as a non-malignant model. The depletion of EIF4G1 and RAN signiﬁcantly reduced cell proliferation and colony formation and increased caspase activity. In particular, the ﬁndings for RAN resemble those observed for other types of cancer. Thus, we evaluated the in vitro eﬀects of importazole (IPZ), a small molecule inhibitor of the interaction between RAN and importin-β. We showed that IPZ could have eﬀects similar to those observed following RAN gene silencing. We also found that primary cell lines from one out of three MPM patients were sensitive to IPZ. As EIF4G1 and RAN deserve further investigation with additional in vitro and in vivo studies, they emerged as promising CDGs, suggesting that their upregulation could play a role in mesothelial tumorigenesis and aggressiveness. Furthermore, present data propose the molecular pathways dependent on RAN as a putative pharmacological target for MPM patients in the view of a future personalized medicine.
Analytic Detection Thresholds for Measurements of Linearly Polarized Intensity Using Rotation Measure Synthesis
Creators: name: Hales, Christopher A.
name: Gaensler, Bryan M.
name: Norris, Ray P.
name: Middelberg, Enno
Publisher: name: arXiv
Year: 2012
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: A fully analytic statistical formalism does not yet exist to describe radio-wavelength measurements of linearly polarized intensity that are produced using rotation measure synthesis. In this work we extend the analytic formalism for standard linear polarization, namely that describing measurements of the quadrature sum of Stokes Q and U intensities, to the rotation measure synthesis environment. We derive the probability density function and expectation value for Faraday-space polarization measurements for both the case where true underlying polarized emission is present within unresolved Faraday components, and for the limiting case where no such emission is present. We then derive relationships to quantify the statistical significance of linear polarization measurements in terms of standard Gaussian statistics. The formalism developed in this work will be useful for setting signal-to-noise ratio detection thresholds for measurements of linear polarization, for the analysis of polarized sources potentially exhibiting multiple Faraday components, and for the development of polarization debiasing schemes.
description: 14 pages, 6 figures, accepted for publication in MNRAS
Targeting SRC family kinases in mesothelioma: Time to upgrade
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2020
Subjects: SRC family kinases
malignant mesothelioma
receptor tyrosine kinases
p27
AKT
invasion
dasatinib
treatment resistance
predictive signature
drug combination

description: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Malignant mesothelioma (MM) is a deadly tumor mainly caused by exposure to asbestos. Unfortunately, no current treatment is able to change significantly the natural history of the disease, which has a poor prognosis in the majority of patients. The non-receptor tyrosine kinase SRC and other SRC family kinase (SFK) members are frequently hyperactivated in many cancer types, including MM. Several works have indeed suggested that SFKs underlie MM cell proliferation, survival, motility, and invasion, overall affecting multiple oncogenic pathways. Consistently, SFK inhibitors effectively counteracted MM cancerous features at the preclinical level. Dasatinib, a multi-kinase inhibitor targeting SFKs, was also assessed in clinical trials either as second-line treatment for patients with unresectable MM or, more recently, as a neoadjuvant agent in patients with resectable MM. Here, we provide an overview of the molecular mechanisms implicating SFKs in MM progression and discuss possible strategies for a more successful clinical application of SFK inhibitors. Our aim is to stimulate discussion and further consideration of these agents in better designed preclinical and clinical studies to make the most of another class of powerful antitumoral drugs, which too often are lost in translation when applied to MM.
Shear Stress Modulates Gene Expression in Normal Human Dermal Fibroblasts
Creators: name: Zabinyakov, Nikita
Publisher: name: Graduate Studies
Year: 2017
Subjects: subject: Engineering--Biomedical
subject: shear stress
subject: Fibroblasts
subject: flow chamber
subject: microarray
subject: pluripotency
subject: trans-differentiation

description: Applied mechanical forces, such as those resulting from fluid flow, trigger cells to change their functional behavior or phenotype. However, there is little known about how fluid flow affects fibroblasts. The hypothesis of this thesis is that dermal fibroblasts undergo significant changes of expression of differentiation genes after exposure to fluid flow (or shear stress). To test the hypothesis, human dermal fibroblasts were exposed to laminar steady fluid flow for 20 and 40 hours and RNA was collected for microarray analysis. Gene expression data was processed using gene network analysis, pathway analysis, and gene functional analysis with comparison to data from publicly available data sets. Additional treatment with PI3K/mTOR pathway inhibitor, PI-103, was performed to evaluate pathway involvement in flow modulation of gene expression. Results from overall transcription analysis demonstrated that fluid flow modulated many genes in fibroblasts including those related to differentiation, development and TGF-β pathway regulation.
Condyle modeling stability, craniofacial asymmetry and ACTN3 genotypes: Contribution to TMD prevalence in a cohort of dentofacial deformities
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2020
Subjects: Actinin
Adult
Chin
Dental Models
Dentofacial Deformities
Face
Female
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Jaw
Male
Malocclusion
Mandibular Condyle
Orthognathic Surgical Procedures
Phosphoric Diester Hydrolases
Polymorphism, Single Nucleotide
Pyrophosphatases
Temporomandibular Joint Disorders

description: © This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. Craniofacial asymmetry, mandibular condylar modeling and temporomandibular joint disorders are common comorbidities of skeletally disproportionate malocclusions, but etiology of occurrence together is poorly understood. We compared asymmetry, condyle modeling stability and temporomandibular health in a cohort of 128 patients having orthodontics and orthognathic surgery to correct dentofacial deformity malocclusions. We also compared ACTN3 and ENPP1 genotypes for association to clinical conditions. Pre-surgical posterior-anterior cephalometric and panometric radiographic analyses; jaw pain and function questionnaire and clinical examination of TMD; and SNP-genotype analysis from saliva samples were compared to assess interrelationships. Almost half had asymmetries in need of surgical correction, which could be subdivided into four distinct morphological patterns. Asymmetric condyle modeling between sides was significantly greater in craniofacial asymmetry, but most commonly had an unanticipated pattern. Often, longer or larger condyles occurred on the shorter mandibular ramus side. Subjects with longer ramus but dimensionally smaller condyles were more likely to have self-reported TMD symptoms (p = 0.023) and significantly greater clinical diagnosis of TMD (p = 0.000001), with masticatory myalgia most prominent. Genotyping found two significant genotype associations for ACTN3 rs1671064 (Q523R missense) p = 0.02; rs678397 (intronic SNP) p = 0.04 and one significant allele association rs1815739 (R577X nonsense) p = 0.00. Skeletal asymmetry, unusual condyle modeling and TMD are common and interrelated components of many dentofacial deformities. Imbalanced musculoskeletal functional adaptations and genetic or epigenetic influences contribute to the etiology, and require further investigation.
Enhanced Oil Recovery from a Low Pressure Tight Oil Reservoir in Ordos Basin
Creators: name: Han, Jiabei
Publisher: name: Graduate Studies
Year: 2016
Subjects: subject: Engineering--Petroleum
subject: Tight Oil
subject: EOR
subject: Gas Injection

description: As one of the biggest sedimentary basins in China, abundant oil reserves exist in the Ordos Basin. Compared with Bakken formation, the pressure of the study area is quite low, which may results in inefficient primary recovery. The primary recovery in the study area has been studied through simulation. The results indicate that primary recovery is not efficient in such a low pressure reservoir. Water or gas should be injected to enhance the oil recovery. Compared with water, gas is more suitable for improving the oil recovery from the study area. Among all gases investigated, CH4 and separator gas are a better choice. The effects of heterogeneity have also been studied by reservoir simulation. As reservoir heterogeneity increases, oil recovery will decrease. However, gas injection can still highly improve the oil recovery. A geological model has been built to predict the gas injection performance in case studies.
COMPARATIVE STUDY OF STUDENT ATTITUDES TOWARDS LGBTQ+ INDIVIDUALS ACROSS ACADEMIC DISCIPLINES
Creators: name: Selin, Yılmaz
Publisher: name: Zap journals
Year: 2023
Subjects: Gender identity
Sexual orientation
Transsexuality
Gender dysphoria
Social role behaviors

description: Gender identity and sexual orientation are complex aspects of human identity. This study explores the intricate interplay between sexual identity, sexual orientation, and social role behaviors, with a focus on the transgender experience. It delves into how an individual's perception and acknowledgment of their body and gender may lead to discomfort and gender dysphoria when it does not align with societal expectations and their own self-awareness. The study examines the journey of transsexual individuals who identify with a gender different from the one assigned at birth and their desire to have primary and secondary characteristics of the opposite gender
Text Classification: A Sequential Reading Approach
Creators: name: Dulac-Arnold, Gabriel
name: Denoyer, Ludovic
name: Gallinari, Patrick
Publisher: name: arXiv
Year: 2011
Subjects: subject: Artificial Intelligence (cs.AI)
subject: Information Retrieval (cs.IR)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: We propose to model the text classification process as a sequential decision process. In this process, an agent learns to classify documents into topics while reading the document sentences sequentially and learns to stop as soon as enough information was read for deciding. The proposed algorithm is based on a modelisation of Text Classification as a Markov Decision Process and learns by using Reinforcement Learning. Experiments on four different classical mono-label corpora show that the proposed approach performs comparably to classical SVM approaches for large training sets, and better for small training sets. In addition, the model automatically adapts its reading process to the quantity of training information provided.
description: ECIR2011
Automated medical abbreviation detection
Creators: name: Ismat, MOHD SULAIMAN
name: Sameem, ABDUL KAREEM
name: Awang, BULGIBA
Publisher: name: Zenodo
Year: 2021
Subjects: medical abbreviation
FastText
electronic medical record
machine learning
automated abbreviation detection

description: Introduction:
 Misinterpreted medical abbreviations has been shown to cause patient harm. Abbreviations in electronic clinical notes are pervasive and ambiguous. The use of abbreviations and misinterpretation will only lead to inaccurate decisions as electronic clinical notes are being reused for research and policy-making. Using Malaysian Cardiology discharge summaries written in English, we compared the results of machine learning approaches to detect abbreviations using rule-based features versus state-of-the-art word embeddings. Method:
 Three datasets were created, each containing 178,451 word-tokens where 23,539 (13.2%) were abbreviations. The first dataset used rule-based features based on word morphology; the second uses FastText vectors as features, and the third uses word embeddings self-trained from Malaysian discharge summaries. The detection model was trained and tested using the decision tree and support vector machine. Results:
 The domain-specific word embedding gave the best result compared to the FastText and rule-base. Conclusion:
 Despite FastText containing more vocabulary and dimensions, the discharge summary embedding with domain-specific vocabulary and smaller dimensions is adequate to detect abbreviations in a semi-supervised machine learning approach. An automated abbreviation detection can alert healthcare providers to improve the quality of clinical documentation, prevent patient harm, and allow a more accurate information extraction for research and policy-making. Disclaimer: Abstract text might vary slightly from what is displayed in the e-poster.
description: This poster was submitted to the 14th National Conference for Clinical Research (NCCR) in August 18-20, 2021. https://nccrconference.com.my/
Density Visualization Pipeline: A Tool for Cellular and Network Density Visualization and Analysis
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2020
Subjects: GABAergic
barrel cortex
density visualization
visual programming
neuronal morphology
synaptogenesis
density maps
interactive data analysis

description: © Copyright © 2020 Grein, Qi and Queisser. Neuron classification is an important component in analyzing network structure and quantifying the effect of neuron topology on signal processing. Current quantification and classification approaches rely on morphology projection onto lower-dimensional spaces. In this paper a 3D visualization and quantification tool is presented. The Density Visualization Pipeline (DVP) computes, visualizes and quantifies the density distribution, i.e., the “mass” of interneurons. We use the DVP to characterize and classify a set of GABAergic interneurons. Classification of GABAergic interneurons is of crucial importance to understand on the one hand their various functions and on the other hand their ubiquitous appearance in the neocortex. 3D density map visualization and projection to the one-dimensional x, y, z subspaces show a clear distinction between the studied cells, based on these metrics. The DVP can be coupled to computational studies of the behavior of neurons and networks, in which network topology information is derived from DVP information. The DVP reads common neuromorphological file formats, e.g., Neurolucida XML files, NeuroMorpho.org SWC files and plain ASCII files. Full 3D visualization and projections of the density to 1D and 2D manifolds are supported by the DVP. All routines are embedded within the visual programming IDE VRL-Studio for Java which allows the definition and rapid modification of analysis workflows.
Quantifying forest fire variability using tree rings Nelson, British Columbia 1700–present
Creators: name: Nesbitt, John Harnisch
Publisher: name: University of British Columbia
Year: 2010

description: This study uses dendroecology to provide direct evidence of historic forest fires and their effects on stand structure and dynamics at a local scale in the montane forests in southeastern British Columbia (BC). Using tree ages and fire-scarred trees, I determined the historic variability of fires by quantifying stand dynamics in relation to past fires in the mixed-conifer forests surrounding Nelson, a wildland-urban interface community in southeastern BC. I built fire records that extended from 1642–2009 across 18 sites in the ~160,000 hectare study area. Although a watershed-level fire signal is evident, site-to-site differences in fire-scar records and stand dynamics suggest that topography and land use caused variability in the fire histories of the individual sites. Numbers of fire-scarred trees and importance values of fire-tolerant trees decreased significantly with elevation. Fire-intolerant trees were most abundant in the subcanopy across all elevations. Most strikingly, no fires were recorded since 1932 across all sites, suggesting that fire exclusion has been effective and that future stands will likely continue to diverge from historic stands by becoming more dense, more homogenous in species composition, and, as a result, more susceptible to high-severity fires.
International connectedness and local disconnectedness: MNE strategy, city-regions and disruption
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2020
Subjects: MNE strategy
global cities
city-regions
disruption
global value chains
off shoring
MNE geography
knowledge transfer

description: © 2020, Academy of International Business. Much of the rising international connectedness of city-regions has developed from MNEs replacing local connections with (superior) international ones. This often creates local disconnectedness that energizes the current populist backlash against MNE activities. We develop approaches to new IB theory, addressing the interdependencies of MNEs and city-regions that we propose as a crucial avenue for future research. We contrast two generic MNE strategies. The first is the traditional one: the ‘global orchestration’ of resources and markets. We argue that it exacerbates local disconnectedness. The second, that we call ‘local spawning,’ involves engaging with the local entrepreneurial eco-system to create and renew local connectedness, diffusing populist responses. Some MNEs are better able to implement a local spawning strategy, due to industry factors like innovation clock-speed, and firm characteristics like organizational path dependency. Finally, we distinguish between disconnection, which is an outcome of MNE strategy, and global disruptions, like the coronavirus (COVID-19) pandemic, which are primarily stochastic events. Addressing disconnections requires MNEs to re-orient their strategies while dealing with disruptions requires undertaking risk mitigation. We present empirical evidence from city-regions around the world to illustrate our theory.
Gröbner bases for the Hilbert ideal and coinvariants of the Dihedral group $D_{2p}$}
Creators: name: Kohls, Martin
name: Sezer, Mufit
Publisher: name: arXiv
Year: 2011
Subjects: subject: Commutative Algebra (math.AC)
subject: FOS: Mathematics
subject: 13A50

description: We consider a finite dimensional representation of the dihedral group $D_{2p}$ over a field of characteristic two where $p$ is an odd prime and study the corresponding Hilbert ideal $I_H$. We show that $I_H$ has a universal Gr\" {o}bner basis consisting of invariants and monomials only. We provide sharp bounds for the degree of an element in this basis and in a minimal generating set for $I_H$. We also compute the top degree of coinvariants.
description: 8 pages
SERRANO DAURA, Josep. Història del dret hispànic i de les seves institucions. Dux, Barcelona, 2021.
Creators: name: Baró Queralt, Xavier
Publisher: name: Revista d'Humanitats
Year: 2023

description: Per a un profà en la matèria, la història del dret esdevé una disciplina tan important com poc fàcil d’assimilar. L’historiador ha de tenir un mínim coneixement, és clar, del conjunt de lleis i institucions jurídiques que s’han anat generant al llarg dels segles en un determinat territori, però tot sovint li manquen eines clares, concises i precises que l’ajudin a destriar el gra de la palla, l’anècdota d’allò que és essencial.
description: Revista d'Humanitats, Núm. 6 (2022)
ИСТОЧНИКИ АЛЬТЕРНАТИВНОЙ ЭНЕРГИИ НА ОСНОВЕ ОРГАНИКИ
Creators: name: Маматов Нурбек Зиёдуллаевич Каршинский инженерно-экономический институт
Publisher: name: Zenodo
Year: 2024

description: Цивилизованный мир давно пришел к пониманию широкой интеграции в области развития возобновляемых источников энергии (ВИЭ), что связано, прежде всего, с истощением углеводородных энергоресурсов, глобальным изменением климата и экологическим ущербом, нанесенным их использованием
The Endurance of the Frankenstein Myth:A History of Ideas
Creators: name: Prescod, Ronald
Publisher: name: Graduate Studies
Year: 2017
Subjects: subject: Mass Communications
subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: Anthropology--Cultural
subject: Frankenstein
subject: Myth
subject: Endurance
subject: Frankenstein foods
subject: biotechnology

description: The term “Frankenstein foods” is an interesting and unique phenomenon. The term represents ideas and themes transported over two hundred years from the novel Frankenstein (Shelley, 1818) to contemporary critical discourse about biotechnology. Most studies of Frankenstein’s endurance have focused on the novel’s intrinsic literary form, that is, its reception history, adaptations, interpretations, its publication, or its canonical status as a classic. However, this thesis is a history of ideas that offers a unique examination of Frankenstein’s endurance in mythical form as the Frankenstein myth. A thematic network reveals a chain of ideologies that connects the original Frankenstein myth to contemporary discourse about biotechnology.
Gravitational Lensing with Three-Dimensional Ray Tracing
Creators: name: Killedar, Madhura
name: Lasky, Paul D.
name: Lewis, Geraint F.
name: Fluke, Chris J.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: High redshift sources suffer from magnification or demagnification due to weak gravitational lensing by large scale structure. One consequence of this is that the distance-redshift relation, in wide use for cosmological tests, suffers lensing-induced scatter which can be quantified by the magnification probability distribution. Predicting this distribution generally requires a method for ray-tracing through cosmological N-body simulations. However, standard methods tend to apply the multiple thin-lens approximation. In an effort to quantify the accuracy of these methods, we develop an innovative code that performs ray-tracing without the use of this approximation. The efficiency and accuracy of this computationally challenging approach can be improved by careful choices of numerical parameters; therefore, the results are analysed for the behaviour of the ray-tracing code in the vicinity of Schwarzschild and Navarro-Frenk-White lenses. Preliminary comparisons are drawn with the multiple lens-plane ray-bundle method in the context of cosmological mass distributions for a source redshift of $z_{s}=0.5$.
description: 17 pages, 10 figures, 0 tables; Accepted for publication in MNRAS