cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
2024 OpenFF Vignettes Mini-workshop
Creators: name: Mitchell, Josh A.
name: Wagner, Jeffrey R
Publisher: name: Zenodo
Year: 2024

description:  The "Things to Make and Do with OpenFF" Mini-workshop, presented by Josh Mitchell of OpenFF.

The OpenFF software ecosystem is a flexible and highly programmable collection of tools that is easy to interface with both cheminformatics suites and MD engines. At the same time, it is oriented towards detecting and rejecting molecular systems that don’t make chemical sense, or that are ambiguous in the chemistry they represent. This makes it quite powerful and pleasant to use for a wide range of biomolecular simulation tasks.

This workshop will display this flexibility by demonstrating a variety of unusual uses of the OpenFF ecosystem and its software neighbors. These “vignettes” will run the gamut from useful to cute, robust to experimental, and simple to complex. Rather than focus on the details of how each is accomplished, vignettes will each be demonstrated quickly alongside a brief highlight of the relevant part of the ecosystem.

You can install the software to run this example and execute the notebook on your own linux or mac computer. This requires an installation of Mamba, Micromamba, or similar conda-forge compatible package manager (see https://docs.openforcefield.org/en/latest/install.html).

First, download the workshop zip file from the zenodo data below, extract the zip file and open a terminal in the extracted directory. Then, create the environment:

mamba env create -n vignettes-workshop -f examples_env.yml

And run Jupyter Lab in the new environment:

mamba run -n vignettes-workshop jupyter lab

Open Force Field examples page: https://docs.openforcefield.org/examples

Open Force Field documentation: https://docs.openforcefield.org

Open Force Field technical support: support@openforcefield.org

Twitter: https://twitter.com/openforcefield

GitHub: https://github.com/openforcefield
Mergers in Seeds and Agricultural Chemicals: What Happened?
Creators: name: MacDonald, James M.
name: MacDonald, James M.
Publisher: name: Unknown
Year: 2019
Subjects: subject: Agricultural and Food Policy
subject: Environmental Economics and Policy
subject: Farm Management
subject: Research and Development/Tech Change/Emerging Technologies
subject: agricultural productivity
subject: agricultural chemicals
subject: pesticides
subject: global seed

description: Six large firms dominated the sale of seeds and agricultural chemicals in 2015 in the United States and around the world: BASF, Bayer, Dow Chemical, DuPont, Monsanto, and Syngenta. The “Big Six” produced and sold crop-protection products such as pesticides, herbicides, and seed treatments. Each firm supported its products with major investments in research and development, leading to improvements that have been an important source of growth in agricultural productivity. In 2015 and 2016, three mergers were announced, encompassing five of the six firms. These mergers led to extensive antitrust reviews by enforcement agencies in the U.S., the European Union, and other countries, with adjustments to the mergers before they were approved.
A study on the solid state characteristics of spray-congealed glyceryl dibehenate solid lipid microparticles containing ibuprofen
Creators: name: Wong, Priscilla Chui Hong
name: Heng, Paul Wan Sia
name: Chan, Lai Wah
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: 60506 Virology

description: Objective: To study the solid state modifications of ibuprofen (IBU)-loaded spray-congealed glyceryl dibehenate (GB) solid lipid microparticles (SLMs) and the influence of polymeric additives using a combination of calorimetric and spectroscopic techniques. Materials and methods: IBU-loaded SLMs were produced by spray congealing with GB as the matrix material. Polyvinyl-2-pyrrolidone-vinyl-acetate (PVP/VA) and ethylcellulose (EC) were employed as additives. Of particular interest in this study were the solid state modifications of the drug and GB matrix induced by spray congealing and the effects of aging, as well as drug–matrix interactions. Fourier transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, differential scanning calorimetry, hot stage microscopy and powder X-ray diffraction provided complementary analyses in understanding drug and lipid matrix polymorphism and interaction. The yield, morphology, drug content and encapsulation efficiencies of SLMs were also investigated. Results and discussion: Drug encapsulation efficiencies and yields of spray congealed SLMs were consistently high for all formulations. GB congealed as an unstable α-polymorph which reverted to the stable β′-polymorph within a few weeks. PVP/VA accelerated the polymorphic conversion in less than a week, while EC took about a year. IBU formed a solid solution with GB regardless of the GB polymorphic form. Conclusions: Spray congealing is efficient for producing drug-loaded SLMs. It induces polymorphic changes in GB. The latter incorporated 20%, w/w IBU as a solid solution and polymeric additives exerted contrasting effects on the GB polymorphic conversion.
Knowledge, attitudes, behaviors, and noise exposure of baristas
Creators: name: Pursley, Alyssa J.
name: Saunders, Gabrielle H.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Objective: To examine the daily noise exposure of baristas working in cafés, and to measure their knowledge, attitudes, and behaviors regarding hearing conservation and perceptions of noise in their work environment. Design: Fifteen baristas from six cafés in Portland completed the Knowledge, Attitudes and Behaviors questionnaire, a sound disturbance survey, and a structured interview to document perceptions of noise in the work environment. To measure daily noise exposure, a subset of eight participants wore a personal dosimeter for three different work shifts. Study sample: A total of 11 females and four males, aged between 19 and 36 years old (mean: 26.3, SD: 4.6) recruited from independently owned cafés in the Portland metro area. Results: Dosimetry measurements revealed Leq measurements between 71 and 83 dBA, with noise doses ranging from 4% to 74%, indicating that baristas are not exposed to sound levels above the regulatory criterion. Questionnaire results indicated that baristas have low awareness about the hazards of noise, are not opposed to hearing conservation, and rarely use hearing protection when engaged in noisy activities. Conclusions: Baristas here lacked the pertinent education and motivation to commit to invaluable hearing conservation practices.
title: 01_0070
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Patogenicidade e efeito comportamental de Photorhabdus temperata K122 nas formigas cortadeiras Acromyrmex subterraneus subterraneus e Atta laevigata (Hymenoptera: Formicidae).
Creators: name: Wesley, D.
Publisher: name: figshare
Year: 2016
Subjects: subject: Zoology
subject: FOS: Biological sciences

description: This study investigated the pathogenicity and virulence of Photorhabdus temperata K122 against leaf-cutting ants Atta laevigata and Acromyrmex subterraneus subterraneus. Three concentrations (1.7 x 101, 1.7 x 102 and 1.7 x 103 bacterias/μL) were tested and the mortality of workers was evaluated at 6-hour intervals during 4 days of experimental period. A concentration of 1.7 x 103 bacteria/μL provoked a high mortality of the two ants species in 24 hours. A. subterraneus subterraneus workers died quicker than A. laevigata at the 3 bacterial concentrations tested. These experiments demonstrated the low susceptibility of these 2 ant species to the entomopathogen P. temperata, indicating a presence of avoidance mechanisms of these insects. In a second experiment we investigated the behavior of moribund ants that frequently died close to cotton balls soaked with 10% honey. To test the hypothesis of a possible attraction to humidity or food, ants were infected with 1.7 x 103 bacteria/μL and introduced into a 10 x 10 x 5 cm plate, with a fungus garden and water-soaked cotton balls at opposite ends. Results showed high LT50 values in these conditions, probably due to the presence of the fungus garden, which guarantees good nutrition condition for ants and produce antibacterial substances. A. subterraneus subterraneus moribund ants frequently died close to the fungus garden, but these patterns were not observed for A. laevigata workers. In relationship to another insects, this work shows the high tolerance of these two leaf-cutting species to P. temperata, with more sensitivity for A. subterraneus subterraneus. A soil habit of the ants suggests the presence of evolution mechanisms against nematode penetration and the toxic effects of symbiotic bacteria.
Sobrevivência de operárias da formiga cortadeira Acromyrmex subterraneus subterraneus (Hymenoptera: Formicidae) quando supridas com diferentes dietas e inibidores enzimáticos.
Creators: name: Wesley, D.
Publisher: name: figshare
Year: 2016
Subjects: subject: Zoology
subject: FOS: Biological sciences

description: Dietas artificiais foram oferecidas para operárias de Acromyrmex subterraneus subterraneus para avaliar a sobrevivência das formigas. TLCK e Triz, inibidores de tripsinas e a-glicosidases, respectivamente, foram oferecidos às operárias para avaliar a sobrevivência e a capacidade inibitória in vitro. Onze tipos de dietas, compostas por ágar, dextrose, flocos de cereais, amidalina, vermiculita e suco de laranja, oferecidas na forma líquida ou sólida (1,5% de ágar) foram avaliadas para testar a sobrevivência das forrageadoras. A sobrevivência também foi avaliada em dieta de dextrose com ágar e 30 μL de uma solução de TLCK ou Triz nas concentrações de 0,1, 0,5 e 1%. Cada tratamento foi composto de 42 formigas avaliadas durante 10 dias. Os tempos letais médios foram calculados pela análise de regressão. Após homogenização e centrifugação, 3 lotes de amostra do intestino médio e 3 do reto foram ensaiados in vitro contra o substrato p-nitrofenil α-D-glicopiranosídeo (NPαGlu), com a presença ou não de Triz para avaliar a porcentagem inibitória de a-glicosidases. A dieta 10% de dextrose em 1,5% de ágar foi a que proporcionou a maior longevidade das operárias, com 8% de mortalidade em 10 dias. TCLK 1% e TRIZ 1% reduziram o tempo de sobrevivência das formigas com um TL50 de 12.3 e 14.1 dias respectivamente (TL50 controle de 16 dias). Nos experimentos in vitro utilizando TRIZ, houve uma inibição de á-glicosidase de 72,5% no intestino médio e de 78,92% no reto. Similarmente a Atta, as operárias de A. subterraneus subterraneus também sobrevivem mais quando com dieta sólida. Tanto TLCK quanto TRIZ causaram mortalidade e inibiram a atividade enzimática podendo ser utilizados como controle ou repelentes de operárias de A.subterraneus subterraneus.
title: 02_0181
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Diferenciación florística a lo largo de un gradiente de perturbación antrópica en un paisaje tropical fragmentado
Creators: name: Gómez-Ruiz, Pilar A.
name: Abril Tapia-Sedeño
name: Ramírez-García, Brenda
name: Pinho, Bruno X.
name: Arroyo-Rodríguez, Víctor
Publisher: name: figshare
Year: 2016
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 50104 Landscape Ecology
subject: FOS: Earth and related environmental sciences

description: El cambio de uso de suelo altera la composición y estructura de las comunidades biológicas, pero su influencia sobre el recambio de especies (diversidad beta) es poco conocida. Ambientes con niveles intermedios de disturbio pueden tener mayor diversidad local y recambio de especies debido al incremento en la heterogeneidad ambiental y dinámica temporal. En este estudio ponemos a prueba la hipótesis de la perturbación intermedia, evaluando la diversidad alfa, beta y gamma de una comunidad de plántulas leñosas dentro de cuatro ambientes (bosque maduro, bosque secundario, cerca viva y milpa) que representan un gradiente de perturbación antrópica en un paisaje tropical fragmentado del sureste mexicano. En ambientes conservados las diversidades alfa y gamma fueron mayores que en los ambientes más perturbado, pero contrario a lo esperado en estos últimos la diversidad beta fue mayor que en los ambientes más conservados. Este hallazgo sugiere que en ecosistemas perturbados se incrementa la diferenciación composicional, probablemente debido a la limitación en la dispersión de semillas y el incremento en la heterogeneidad de las condiciones ambientales. Por tanto, la conservación de diferentes coberturas vegetales en estos paisajes puede contribuir al mantenimiento de la diversidad de plantas en paisajes tropicales fragmentados.
Teofrasto. História das Plantas. Tradução portuguesa, com Introdução e Anotação de Maria de Fátima Sousa e Silva & Jorge Paiva, Coimbra: Imprensa da Universidade de Coimbra/ Annablume, Série “Diaita: Scripta & Realia”. 2016. 459 pp.
Creators: name: Brasete, Maria Fernanda
Publisher: name: Ágora. Estudos Clássicos em Debate
Year: 2019

description: Esta obra, que apresenta a primeira tradução portuguesa da História das plantas, de Teofrasto (c.371-286 a.C.), resulta da colaboração de dois Professores da Universidade de Coimbra, uma helenista e um botânico, por forma a garantir uma tradução rigorosa do original grego, anotações de cariz científico fidedignas e índices precisos dos nomes (gregos e latinos, acom-panhados da respetiva tradução) das plantas, de animais e vegetais, e ainda de topónimos.
description: Ágora. Estudos Clássicos em Debate, n.º 19 (2017)
RODERICK W. HOME, ISABEL M. MALAQUIAS & MANUEL F. THOMAZ (eds.), For the Love of Science. The Correspondence of J. H. de Magellan (1722–1790). Bern, Bruxelles, Frankfurt am Main, New York, Oxford, Warszawa, Wien, Peter Lang, 2017, 2 vols., 2002 pp.
Creators: name: Andrade, António
Publisher: name: Ágora. Estudos Clássicos em Debate
Year: 2019

description: A recente publicação da monumental obra em epígrafe, resultado de dezenas de anos de aturada investigação e labor da parte dos seus três edi-tores, representa um contributo da maior valia para o conhecimento de João Jacinto de Magalhães, uma figura ímpar da cultura portuguesa e europeia do século XVIII. De facto, encontra-se pela primeira vez reunida e disponível nestes dois grossos volumes a abundante correspondência que este aveirense ilustre trocou com inúmeros indivíduos, tanto portugueses como estran-geiros, desde amigos ou simples conhecidos até nobres ou diplomatas de vários países. Contam-se entre os seus inúmeros correspondentes algumas das figuras mais proeminentes da Europa das Luzes, nomeadamente no campo da História da Ciência e da Técnica. Na verdade, Jacinto de Magalhães trocava informações muito diversas, nomeadamente sobre os avanços em várias áreas do saber ou sobre instrumentação científica, tendo estabelecido uma rede de contactos alargada com alguns dos filósofos e cientistas mais destacados da época, entre os quais se contam, entre muitos outros, Antoine-Laurent Lavoisier, Johann Albrecht Euler, Alessandro Volta, Benjamin Franklin, Charles Messier, Jérôme Lalande, Thomas Hornsby, Johann III Bernoulli ou James Watt. Entre os correspondentes portugueses, sublinha-se a importância das inúmeras cartas trocadas entre João Jacinto de Magalhães e o seu grande amigo Ribeiro Sanches, fonte privilegiada para o conheci-mento de múltiplos aspetos do Portugal de Setecentos, apesar de ambos terem vivido grande parte das suas vidas fora do país.
description: Ágora. Estudos Clássicos em Debate, n.º 19 (2017)
Influencia de la disponibilidad de luz sobre el área foliar de la comunidad de plantas leñosas en un bosque tropical húmedo
Creators: name: Muñoz, Marilyn Castillo
name: Salcedo, Citlali Aguirre
name: Siunelly Sarai Landero Lozada
name: Melo, Felipe P. L.
Publisher: name: figshare
Year: 2016
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: En bosques tropicales, la disponibilidad de recursos actúa como un filtro ecológico seleccionando especies de acuerdo a sus atributos funcionales. En ambientes con baja disponibilidad de luz resulta costoso reponer el tejido foliar, por lo que las plantas presentan una disyuntiva funcional entre asignar recursos a la defensa o al crecimiento. En este trabajo evaluamos la influencia de la disponibilidad de luz sobre la diversidad funcional del área foliar de la comunidad de plantas leñosas. Seleccionamos tres sitios con diferente disponibilidad de luz: (1) bosque secundario temprano (alta disponibilidad), (2) bosque secundario intermedio (disponibilidad intermedia) y (3) bosque maduro (baja disponibilidad). Obtuvimos la media ponderada de la comunidad (CWM) y calculamos los índices de equitatividad (FEve) y dispersión funcional (FDis). Encontramos mayor variación en bosque secundario temprano (FDis = 0.16) e intermedio (FDis = 0.14), que en el bosque maduro (FDis = 0.01). La equitatividad fue mayor en el bosque maduro (FEve = 0.75) que en etapas temprana (FEve = 046) e intermedia (FEve = 0.49) de regeneración. Estos resultados sugieren una complementariedad y redundancia funcional en el bosque temprano y maduro, respectivamente. Este conocimiento podría contribuir al mejoramiento de prácticas de restauración mediante la selección de especies con elevada tasa de crecimiento, eficiencia fotosintética o resistencia a la herbivoría.
Effects of nano-TiO2 on perfluorooctanesulfonate bioaccumulation in fishes living in different water layers: Implications for enhanced risk of perfluorooctanesulfonate
Creators: name: Liwen Qiang
name: Xiaoyu Pan
name: Lingyan Zhu
name: Shuhong Fang
name: Shengyan Tian
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Cancer
subject: Inorganic Chemistry

description: Nano-titanium dioxide (nano-TiO2) is one of the most universal engineered nano-materials while perfluorooctanesulfonate (PFOS) is a typical new persistent organic pollutant. They are widely used and present in aquatic environment. In this study, a novel semi-static multilayer microcosm was setup to investigate the impacts of nano-TiO2 on PFOS bioaccumulation in fish species [Danio rerio (D. rerio), Ctenopharyngodon idella (C. idella), Hypostomus plecostomus (H. plecostomus)] living in different vertical layers. As a result of aggregation and deposition, the concentration of TiO2 increased from upper to bottom layers in the water column. Concomitantly, due to adsorption of PFOS on the nano-TiO2 particles, PFOS also displayed an increasing trend from upper to bottom layer. Owing to ingestion of the TiO2–PFOS complexes, more PFOS was taken-up by fish. With the aid of intestinal fluid, PFOS was readily released from TiO2 particles and absorbed by fish. As a result, accumulation of PFOS in whole fish was facilitated and the bioaccumulation factors of PFOS in D. rerio, C. idella and H. plecostomus were 3.01, 2.42 and 1.11 times of that in the groups without TiO2. However, TiO2 aggregates were too large to penetrate biological membranes to participate body circulation, and no significant accumulation of TiO2 was observed in fish muscle. The results suggested that the ecological risk of PFOS could be enhanced due to the presence of nano-TiO2 in water.
title: Hacking Art Education. Arte Útil as an educational methodology to foster change for curriculum planning
Creators: name: Saviotti, A
Publisher: name: Liverpool John Moores University
Year: 2024

description: This thesis examines the principles of Arte Útil and their application in art education to formulate a new methodology for the composition of the curriculum as a tool for change in both museums and universities. I contend that, previous attempts to apply a change in curriculum planning that emerged in the context of socially engaged art avoided outlining a methodology to be employed in educational institutions. Therefore, this thesis’ overarching aim is to demonstrate how Arte Útil, in applying both art-based methods in tandem with educational methodologies - proposed by socially engaged art, feminist-engaged pedagogy and the undercommons – for the conception of the curriculum furthers institutional change on many levels. What emerged from applying a qualitative method during action research and from the case studies analysed for this thesis, is that artists often infiltrate the institution of education through their artworks. The institution typically welcomes their intervention as if it was ‘just’ art when, in fact, the implementation of curriculum changes. Hence, I argue how unconventional education models, framed as Arte Útil, could be successfully implemented within schools, universities and museums. The result is the development of long-term pedagogic sustainability through processes of participatory institutional hacking. Undertaken with multiple cohorts of students and communities of practice, this thesis situates across museum studies and education. It concludes in the production of a curriculum-as-a-toolkit – such as Hacking (Art) Education, available as a website - that includes a series of resources in the form of syllabi, scores for workshops, and exercises, a glossary and a timeline that can be used to infiltrate schools, universities, and museums through the application of the principles of Arte Útil that constitute a new educational methodology.
Invisible Power Players in Climate Change
Creators: name: Looby, Caitlin
name: Treseder, Kathleen
Publisher: name: figshare
Year: 2016
Subjects: subject: Environmental Science
subject: 50101 Ecological Impacts of Climate Change
subject: FOS: Earth and related environmental sciences
subject: 40104 Climate Change Processes
subject: Microbiology
subject: FOS: Biological sciences

description: This article was published in the Climate Change issue of Cultures Magazine published by the American Society for Microbiology.
Survival of Burgess Shale-type animals in a Middle Ordovician deep-water setting
Creators: name: Hearing, Thomas W.
name: Legg, David A.
name: Botting, Joseph P.
name: Muir, Lucy A.
name: McDermott, Patrick
name: Faulkner, Stephanie
name: Taylor, Adam C.
name: Brasier, Martin D.
Publisher: name: Geological Society of London
Year: 2016
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: Appendix 2: Sedimentological Examples
Survival of Burgess Shale-type animals in a Middle Ordovician deep-water setting
Creators: name: Hearing, Thomas W.
name: Legg, David A.
name: Botting, Joseph P.
name: Muir, Lucy A.
name: McDermott, Patrick
name: Faulkner, Stephanie
name: Taylor, Adam C.
name: Brasier, Martin D.
Publisher: name: Geological Society of London
Year: 2016
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: Appendix 1: Assemblage Composition
Leiden Manifesto: a brief translation in Persian
Creators: name: Zahedi, Zohreh
Publisher: name: figshare
Year: 2016
Subjects: subject: Library and Information Studies
subject: FOS: Media and communications

description: a brief translation of Leiden manifesto in Persian language
http://www.leidenmanifesto.org/
http://goo.gl/ryi16B
PAC-Australia (2023): Recording with TR, "A Christmas interview"
Creators: name: Mas, Erwanne
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Australian English
subject: eng

description: PAC-LVTI Reading Task
description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
Therapeutic effect for liver-metastasized tumor by sequential intravenous injection of anionic polymer and cationic lipoplex of siRNA
Creators: name: Hattori, Yoshiyuki
name: Arai, Shohei
name: Kikuchi, Takuto
name: Kei-Ichi Ozaki
name: Kawano, Kumi
name: Yonemochi, Etsuo
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Previously, we developed a novel siRNA transfer method to the liver by sequential intravenous injection of anionic polymer and cationic liposome/siRNA complex (cationic lipoplex). In this study, we investigated whether siRNA delivered by this sequential injection could significantly suppress mRNA expression of the targeted gene in liver metastasis and inhibit tumor growth. When cationic lipoplex was intravenously injected into mice bearing liver metastasis of human breast tumor MCF-7 at 1 min after intravenous injection of chondroitin sulfate C (CS) or poly-l-glutamic acid (PGA), siRNA was accumulated in tumor-metastasized liver. In terms of a gene silencing effect, sequential injections of CS or PGA plus cationic lipoplex of luciferase siRNA could reduce luciferase activity in liver MCF-7-Luc metastasis. Regarding the side effects, sequential injections of CS plus cationic lipoplex did not exhibit hepatic damage or induction of inflammatory cytokines in serum after repeated injections, but sequential injections of PGA plus cationic lipoplex did. Finally, sequential injections of CS plus cationic lipoplex of protein kinase N3 siRNA could suppress tumor growth in the mice bearing liver metastasis. From these findings, sequential injection of CS and cationic lipoplex of siRNA might be a novel systemic method of delivering siRNA to liver metastasis.
Plan de cuidados para el lactante en barrio de acción preferente
Creators: name: Cortés, Javier
Publisher: name: Zenodo
Year: 2020
Subjects: PAE
Cuidados
Enfermería
Lactante
Barrio
Acción Preferente

description: Propuesta de Plan de cuidados (PAE) para el lactante en barrio de acción preferente.
description: TFG
title: PAC-Australia (2023): Recording with TR, word list n°1
title: 2019 - post PSS2
titleType: AlternativeTitle
Creators: name: Mas, Erwanne
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Australian English
subject: eng

description: PAC word list n°1
description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
Johanna Hanink (2017), The Classical Debt. Greek Antiquity in an Era of Austerity. Cambridge (MA) & London, Harvard University Press, 338 pp.
Creators: name: González Vaquerizo, Helena
Publisher: name: Ágora. Estudos Clássicos em Debate
Year: 2019

description: En su reciente monografía Johanna Hanink, profesora titular de Clásicas en la Universidad de Brown, aborda la cuestión de la “deuda griega” no desde el punto de vista de lo que Grecia debe a sus acreedores financieros, sino desde el de la deuda que la civilización occidental tiene contraída con la Antigüedad clásica. Esta “deuda clásica” se compone del legado inmaterial que conformarían principios como la democracia, la filosofía, las matemáticas o el arte, y de los restos materiales de una cultura en la que ha querido verse el origen de la civilización occidental. Hanink estudia el papel de la Antigüedad griega en el periodo de austeridad propiciado por la crisis económica aplicando conceptos bien asentados sobre la idealización del pasado griego desde la propia Atenas clásica, pasando por los siglos XVIII y XIX y hasta nuestros días. El interés fundamental del estudio radica, por un lado, en la constatación de los efectos del “cripto‐colonialismo” (Michael Hertzfeld) o “colonización de la mente” (Artemis Leontis) sobre Grecia y en especial en el contexto de la crisis. Por otro, en la paradoja, implícita en el título y presente a lo largo del trabajo, de que el país más endeudado de Europa sea aquél al que nuestras sociedades reconocen deber más en el plano intelectual. (...)
description: Ágora. Estudos Clássicos em Debate, n.º 20 (2018)
Evaluation of a short-term topical interferon α-2b treatment for histologically proven melanoma and primary acquired melanosis with atypia
Creators: name: Garip, Aylin
name: Schaumberger, Markus M.
name: Wolf, Armin
name: Herold, Tina R.
name: Miller, Christina V.
name: Klingenstein, Annemarie
name: Schebitz-Walter, Kirsten
name: Hintschich, Christoph R.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Objective: To evaluate the efficiency of series of 6-week treatments with brief intervals (6-week = 1 cycle) of topical Interferon α-2b (IFNα-2b) treatment in primary acquired melanosis (PAM) with atypia and melanoma of the conjunctiva. Patients and Methods: Five patients with biopsy-proven PAM with atypia and seven patients with melanoma of the conjunctiva, treated with topical IFNα-2b (1 million units/ml, 5 times daily), were included in the study. All patients had colour photographs and the tumour area was measured manually for each patient before and after treatment. Results: The median age of 12 patients at initiation of treatment was 61.5 years (range 39–75 years). The mean therapy duration was 2.4 cycles (range 1-6 cycle). Compared to pretreatment lesion dimension, the mean decrease in tumour size were after the first cycle 66% (range 18–98%; p = 0.004; n = 10 patients), after the second cycle 55% (range 10–100%; p = 0.016; n = 7 patients), and after the third cycle 74% (range 23–100%; n = 3 patients). In one patient 6 cycles of topical IFNα-2b were needed. The decrease in size was 22% after the 4th cycle, 34% after the 5th cycle, and 98% after the 6th cycle. Conclusion: Our clinical experience demonstrates promising results of topical IFNα-2b treatment for PAM with atypia and melanoma of the conjunctiva without any local or systemic side effects. However, future multicenter prospective studies are recommended to confirm the efficiency and safety of topical IFNα-2b treatment.
A novel role for the deubiquitinase USP1 in the control of centrosome duplication
Creators: name: Jung, Jin Ki
name: Seok-Won Jang
name: Kim, Jung Min
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Defects in the regulation of centrosome duplication lead to tumorigenesis through abnormal cell division and resulting chromosome missegregation. Therefore, maintenance of accurate centrosome number is critical for cell fate. The deubiquitinating enzyme USP1 plays important roles in DNA repair and cell differentiation. Importantly, increased levels of USP1 are detected in certain types of human cancer, but little is known about the significance of USP1 overexpression in cancer development. Here we show that Usp1 plays a novel role in regulating centrosome duplication. The ectopic expression of wild-type Usp1, but not C90S Usp1 (catalytically inactive mutant form), induced centrosome amplification. Conversely, ablation of Usp1 in mouse embryonic fibroblasts (MEFs) showed a significant delay in centrosome duplication. Moreover, Usp1-induced centrosome amplification caused abnormal mitotic spindles, chromosome missegregation and aneuploidy. Interestingly, loss of inhibitor of DNA binding protein 1 (ID1) suppressed Usp1-induced centrosome amplification. Taken together, our results strongly suggest that Usp1 is involved in the regulation of centrosome duplication, at least in part via ID1, and Usp1 may exert its oncogenic activity, partially through inducing centrosome abnormality.
Françoise Frazier & Olivier Guerrier (coords.), Plutarque. Éditions, Traductions, Paratextes. Coimbra e São Paulo, Imprensa da Universidade de Coimbra e Annablume, 2016. 229 pp.
Creators: name: Pinheiro, Joaquim
Publisher: name: Ágora. Estudos Clássicos em Debate
Year: 2019

description: Reúne este volume trabalhos que foram apresentados no Réseau Thématique Plutarque Européen, na Universidade de Toulouse, que decorreu em Setembro de 2014. Coincidiu, infelizmente, a sua publicação com o falecimento da Professora Françoise Frazier, ilustre classicista e uma das principais investigadoras, nas duas últimas decádas, da obra de Plutarco. Com toda a justiça, o livro abre com uma nota prévia, em que, de forma breve, são realçados os valores da mulher e o saber da professora, com especial ênfase no seu extraordinário trabalho científico, filológico e pedagógico. Os caminhos de análise filológica, de grande profundidade filosófica, que foi abrindo são a maior herança que Françoise Frazier nos deixa, sobretudo para aqueles que de forma mais próxima foram ouvindo as suas lições e reflexões. (...)
description: Ágora. Estudos Clássicos em Debate, n.º 20 (2018)
Dealing with discordance: a novel approach for analysing U–Pb detrital zircon datasets
Creators: name: Reimink, Jesse R.
name: Davies, Joshua H.F.L.
name: Waldron, John W.F.
name: Rojas, Xavier
Publisher: name: Geological Society of London
Year: 2016
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: The code used for writing the model, along with an instruction guide
Ana María S. Tarrío, Leitores dos Clássicos. Portugal e Itália, séculos XV e XVI: uma geografia do primeiro humanismo em Portugal. Nota de Vincenzo Fera. Lisboa, Biblioteca Nacional de Portugal – Centro de Estudos Clássicos, 2015, 127 pp.
Creators: name: Van Binnebeke, Xavier
Publisher: name: Ágora. Estudos Clássicos em Debate
Year: 2019

description: The publication under review documents the exhibition Leitores dos Clássicos. Edições italianas na transição do século XV para o século XVI, held from 6 November 2015 to 30 January 2016 in the Biblioteca Nacional de Portugal (BNP). Twenty items from the library were on show: sixteen Italian incunabula, three Spanish ones, and a book issued in Basle in the 16th century9. The catalogue, authored by Ana Tarrío of the Centro de Estudos Clássicos in Lisbon, opens with a prologue that positions Portugal during the reigns of João II and Manuel I on the fringes of the Europe‐wide intellectual, educational, and literary culture and practice of humanism. Three exhibition items — Inc. 523, 832, and 462 — are explicitly singled out on the basis of their provenance and contemporary marginalia. They embody the import of humanist editions of the Classics from Italy to Portugal, the development of education and literary composition at the Portuguese court, and the philological preparation of Portuguese students in Italy. The other exhibits are similarly presented as witnesses to these developments, though signs of their use in Portugal during the late 15th and early 16th centuries are said to be less evident. Tarrío underscores, in addition, the need for further investigations into the Italian incunabula of the BNP and other Portuguese collections, and announces that the materials on show will be relevant for her thematic epilogue dealing with the chronology and definition of Portuguese humanism, a difficult field of research « inteiramente dependente da elucidação da cronologia e modalidades de receção dos modelos humanísticos oriundos da Península Itálica.» (11). (...)
description: Ágora. Estudos Clássicos em Debate, n.º 20 (2018)
Dealing with discordance: a novel approach for analysing U–Pb detrital zircon datasets
Creators: name: Reimink, Jesse R.
name: Davies, Joshua H.F.L.
name: Waldron, John W.F.
name: Rojas, Xavier
Publisher: name: Geological Society of London
Year: 2016
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: R code in a .doc file. Copy and paste into R code
Competence Modeling for Human-Robot Cooperation
Creators: name: Limberg, Christian
Publisher: name: Universität Bielefeld
Year: 2022
Subjects: subject: 000

description: Autonomous robots are going to become an increasingly important part of humans' everyday life. Currently, not many tasks could be automated completely, so it is still necessary, and sometimes even preferable, to take the human in the loop. There is a wide range of unsolved challenges in such a Human Robot Cooperation. One of them is the modeling of competence, which concerns the estimation of the capabilities of both interaction partners towards a common goal. From a robot's point of view, this does not only mean awareness of its own but also of human capabilities.

 The thesis focuses on competence modeling regarding active and incremental classification. Within a generic scenario where the human uses his world knowledge about the environment for teaching the robot, we have identified three different areas where competence modeling is elementary:

 First, the robot should be able to assess its own capabilities. We show that it is possible to estimate classification accuracy in a semi-supervised manner using a static regression model trained on histograms of confidences computed on unlabeled samples in active learning.

 Second, the robot should assess its teacher's capabilities because sometimes the human teacher does not have perfect domain knowledge. We propose an additional model that is, by excluding ambiguous areas in feature space, capable of increasing training speed by showing uncertain but valuable samples to the user for labeling.

 Finally, bringing the two complementary partners together is the last cornerstone of this thesis. We introduce an active learning querying technique utilizing dimension-reduction approaches for realizing a visualization of deep image feature spaces for the human. Non-expert humans can label robot object recordings faster and more qualitatively using this new teaching interface. That was revealed by a user study we conducted. However, the proposed method adds specific demands to the Machine Learning model for handling non-i.i.d. training data. Therefore, we investigate several approaches enabling instance-based classifier for compensating these conditions.
Protein cofactor competition regulates the action of a multifunctional RNA helicase in different pathways
Creators: name: Heininger, Annika U.
name: Hackert, Philipp
name: Andreou, Alexandra Z.
name: Kum-Loong Boon
name: Memet, Indira
name: Prior, Mira
name: Clancy, Anne
name: Schmidt, Bernhard
name: Urlaub, Henning
name: Schleiff, Enrico
name: Sloan, Katherine E.
name: Deckers, Markus
name: Lührmann, Reinhard
name: Enderlein, Jörg
name: Klostermeier, Dagmar
name: Rehling, Peter
name: Bohnsack, Markus T.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine

description: A rapidly increasing number of RNA helicases are implicated in several distinct cellular processes, however, the modes of regulation of multifunctional RNA helicases and their recruitment to different target complexes have remained unknown. Here, we show that the distribution of the multifunctional DEAH-box RNA helicase Prp43 between its diverse cellular functions can be regulated by the interplay of its G-patch protein cofactors. We identify the orphan G-patch protein Cmg1 (YLR271W) as a novel cofactor of Prp43 and show that it stimulates the RNA binding and ATPase activity of the helicase. Interestingly, Cmg1 localizes to the cytoplasm and to the intermembrane space of mitochondria and its overexpression promotes apoptosis. Furthermore, our data reveal that different G-patch protein cofactors compete for interaction with Prp43. Changes in the expression levels of Prp43-interacting G-patch proteins modulate the cellular localization of Prp43 and G-patch protein overexpression causes accumulation of the helicase in the cytoplasm or nucleoplasm. Overexpression of several G-patch proteins also leads to defects in ribosome biogenesis that are consistent with withdrawal of the helicase from this pathway. Together, these findings suggest that the availability of cofactors and the sequestering of the helicase are means to regulate the activity of multifunctional RNA helicases and their distribution between different cellular processes.
C. Morais, L. Hardwick, and M. de F. Silva, (Eds.). (2017). Portrayals of Antigone in Portugal 20th and 21st Century Rewritings of the Antigone Myth. Leiden: Brill Academic Pub., Series: Metaforms, Studies in the Reception of Classical Antiquity, Vol 9.
Creators: name: Brasete, Maria Fernanda
Publisher: name: Ágora. Estudos Clássicos em Debate
Year: 2019

description: Sob a chancela da prestigiada editora Brill Academic Pub., o volume em epígrafe representa o culminar de uma longa e aturada investigação empreendida por académicos de várias instituições universitárias, nacionais e internacionais, sobre as denominadas Antígonas portuguesas. É inegável o valor científico e a importância da presente obra, centrada na receção do mito de Antígona na dramaturgia portuguesa dos séculos XX e XXI, com o mérito acrescido de se tratar de uma publicação em língua inglesa, acessível, por isso, a um público leitor muito dilatado. (...)
description: Ágora. Estudos Clássicos em Debate, n.º 20 (2018)
Influence of inoculum and climatic factors on the severity of Fusarium head blight in German spring and winter barley
Creators: name: Linkmeyer, Andrea
name: Hofer, Katharina
name: Rychlik, Michael
name: Herz, Markus
name: Hausladen, Hans
name: Hückelhoven, Ralph
name: Hess, Michael
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology
subject: 60506 Virology

description: Fusarium head blight (FHB) of small cereals is a disease of global importance with regard to economic losses and mycotoxin contamination harmful to human and animal health. In Germany, FHB is predominantly associated with wheat and F. graminearum is recognised as the major causal agent of the disease, but little is known about FHB of barley. Monitoring of the natural occurrence of FHB on Bavarian barley revealed differences for individual Fusarium spp. in incidence and severity of grain infection between years and between spring and winter barley. Parallel measurement of fungal DNA content in grain and mycotoxin content suggested the importance of F. graminearum in winter barley and of F. langsethiae in spring barley for FHB. The infection success of these two species was associated with certain weather conditions and barley flowering time. Inoculation experiments in the field revealed different effects of five Fusarium spp. on symptom formation, grain yield and mycotoxin production. A significant association between fungal infection of grain and mycotoxin content was observed following natural or artificial infection with the type B trichothecene producer F. culmorum, but not with the type A trichothecene-producing species F. langsethiae and F. sporotrichioides. Trichothecene type A toxin contamination also occurred in the absence of significant damage to grain and did not necessarily promote fungal colonisation.