cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Cost-effectiveness of targeted screening for non-valvular atrial fibrillation in the United Kingdom in older patients using digital approaches
Creators: name: Patel, Shreeya
name: Kongnakorn, Thitima
name: Nikolaou, Andreas
name: Javaid, Yassir
name: Mokgokong, Ruth
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Screening for non-valvular atrial fibrillation (NVAF) is key in identifying patients with undiagnosed disease who may be eligible for anticoagulation therapy. Understanding the economic value of screening is necessary to assess optimal strategies for payers and healthcare systems. We evaluated the cost effectiveness of opportunistic screening with handheld digital devices and pulse palpation, as well as targeted screening predictive algorithms for UK patients ≥75 years of age. A previously developed Markov cohort model was adapted to evaluate clinical and economic outcomes of opportunistic screening including pulse palpation, Zenicor (extended 14 days), KardiaMobile (extended), and two algorithms compared to no screening. Key model inputs including epidemiology estimates, screening effectiveness, and risks for medical events were derived from the STROKESTOP, ARISTOTLE studies, and published literature, and cost inputs were obtained from a UK national cost database. Health and cost outcomes, annually discounted at 3.5%, were reported for a cohort of 10,000 patients vs. no screening over a time horizon equivalent to a patient’s lifetime, Analyses were performed from a UK National Health Services and personal social services perspective. Zenicor, pulse palpation, and KardiaMobile were dominant (providing better health outcomes at lower costs) vs. no screening; both algorithms were cost-effective vs. no screening, with incremental cost-effectiveness ratios per quality-adjusted life-year (QALY) of £1,040 and £1,166. Zenicor, pulse palpation, and KardiaMobile remained dominant options vs. no screening in all scenarios explored. Deterministic sensitivity analyses indicated long-term stroke care costs, prevalence of undiagnosed NVAF in patients 75–79 years of age, and clinical efficacy of anticoagulant on stroke prevention were the main drivers of the cost-effectiveness results. Screening for NVAF at ≥75 years of age could result in fewer NVAF-related strokes. NVAF screening is cost-effective and may be cost-saving depending on the program chosen.
Photon-added coherent states for shape invariant systems
Creators: name: Sodoga, Komi
name: Hounkonnou, Mahouton Norbert
name: Aremua, Isiaka
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: This paper addresses a full characterization of photon-added coherent states for shape-invariant potentials. Main properties are investigated and discussed. A statistical computation of relevant physical quantities is performed, emphasizing the importance of using generalized hypergeometric functions $_pF_q$ and Meijer's $G$-functions for such a study.
Additional file 1: of Combined Cognitive-Behavioural and Physiotherapeutic Therapy for Patients with Chronic Pelvic Pain Syndrome (COMBI-CPPS): study protocol for a controlled feasibility trial
Creators: name: Brünahl, Christian
name: Klotz, Susanne
name: Dybowski, Christoph
name: Riegel, Björn
name: Gregorzik, Sonja
name: Tripp, Dean
name: Ketels, Gesche
name: Löwe, Bernd
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) checklist (DOC 120 kb)
Mechanisms for tuning clustering and degree-correlations in directed networks
Creators: name: Kashyap, G.
name: Ambika, G.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Social and Information Networks (cs.SI)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: With complex networks emerging as an effective tool to tackle multidisciplinary problems, models of network generation have gained an importance of their own. These models allow us to extensively analyze the data obtained from real-world networks, study their relevance and corroborate theoretical results. In this work, we introduce methods, based on degree preserving rewiring, that can be used to tune the clustering and degree-correlations in directed networks with random and scale-free topologies. They provide null-models to investigate the role of the mentioned properties along with their strengths and limitations. We find that in the case of clustering, structural relationships, that are independent of topology and rewiring schemes are revealed, while in the case of degree-correlations, the network topology is found to play an important role in the working of the mechanisms. We also study the effects of link-density on the efficiency of these rewiring mechanisms and find that in the case of clustering, the topology of the network plays an important role in determining how link-density affects the rewiring process, while in the case of degree-correlations, the link-density and topology, play no role for sufficiently large number of rewiring steps. Besides the intended purpose of tuning network properties, the proposed mechanisms can also be used as a tool to reveal structural relationships and topological constraints.
description: 8 pages, 11 figures, submitted to Physical Review E
Cost-effectiveness of alternative first- and second-line treatments for benign prostatic hyperplasia in Singapore
Creators: name: Chay, Junxing
name: Tung, Joshua Yi Min
name: Su, Rebecca Jade
name: Aslim, Edwin Jonathan
name: Wong, Callix
name: Swan, Georgia
name: Chua, Wei Jin
name: Ho, Henry Sun Sien
name: Finkelstein, Eric Andrew
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Cancer
subject: Science Policy

description: Minimally invasive surgical therapies, such as water vapor thermal therapy (WVTT) and prostatic urethral lift (PUL), are typically second-line options for patients in whom medical management (MM) failed but who are unwilling or unsuitable to undergo invasive transurethral resection of the prostate (TURP). However, the incremental cost-effectiveness of WVTT or PUL as first- or second-line therapy is unknown. We evaluated the incremental cost-effectiveness of alternative first- and second-line treatments for patients with moderate-to-severe benign prostatic hyperplasia (BPH) in Singapore to help policymakers make subsidy decisions based on value for money. We considered six stepped-up treatment strategies, beginning with MM, WVTT, PUL or TURP. In each strategy, patients requiring retreatment advance to a more invasive treatment until TURP, which may be undergone twice. A Markov cohort model was used to simulate transitions between BPH severity states and retreatment, accruing costs and quality-adjusted life-years (QALYs) over a lifetime horizon. In moderate patients, strategies beginning with MM had similar cost and effectiveness, and first-line WVTT was incrementally cost-effective to first-line MM (33,307 SGD/QALY). First-line TURP was not incrementally cost-effective to first-line WVTT (159,361 SGD/QALY). For severe patients, WVTT was incrementally cost-effective to MM as a first-line treatment (30,133 SGD/QALY) and to TURP as a second-line treatment following MM (6,877 SGD/QALY). TURP was incrementally cost-effective to WVTT as a first-line treatment (48,209 SGD/QALY) in severe patients only. All pathways involving PUL were dominated (higher costs and lower QALYs). Based on the common willingness-to-pay threshold of SGD 50,000/QALY, this study demonstrates the cost-effectiveness of WVTT over MM as first-line treatment for patients with moderate or severe BPH, suggesting it represents good value for money and should be considered for subsidy. PUL is not cost-effective as first- nor second-line treatment. For patients with severe BPH, TURP as first-line is also cost-effective.
Electromagnetic form factors at large momenta from lattice QCD
Creators: name: Chambers, A. J.
name: Dragos, J.
name: Horsley, R.
name: Nakamura, Y.
name: Perlt, H.
name: Pleiter, D.
name: Rakow, P. E. L.
name: Schierholz, G.
name: Schiller, A.
name: Somfleth, K.
name: Stüben, H.
name: Young, R. D.
name: Zanotti, J.
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: Accessing hadronic form factors at large momentum transfers has traditionally presented a challenge for lattice QCD simulations. Here we demonstrate how a novel implementation of the Feynman-Hellmann method can be employed to calculate hadronic form factors in lattice QCD at momenta much higher than previously accessible. Our simulations are performed on a single set of gauge configurations with three flavours of degenerate mass quarks corresponding to $m_π\approx 470 \text{ MeV}$. We are able to determine the electromagnetic form factors of the pion and nucleon up to approximately $6 \text{ GeV}^2$, with results for $G_E/G_M$ in the proton agreeing well with experimental results.
TranslationSpecification_ICOADS-DOMS_v9.pdf
Creators: name: Cram, Thomas
name: Ji, Zaihua
name: Worley, Steven J.
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 370803
subject: Physical oceanography

description: The document outlines the standardization of ICOADS Release 3.0 in-situ data to support the DOMS and CDMS software. To make the DOMS matchup output meaningful and easy to use the collaborating partners must standardize their data within the DOMS prototype. This document defines the translation of ICOADS data from the ICOADS Value-Added Database (IVADDB), a PostgreSQL database, into a JSON exchange format suitable for ingestion into Apache Solr or ElasticSearch.
title: ADCO, Sixième cartulaire de Saint-Étienne de Dijon (1662), Cart. 30 (G 133), 441 folios, f. 397
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi

description: Sixième cartulaire de Saint-Étienne de Dijon (1662), Archives départementales de la Côte-d'Or, Cart. 30 (G 133), 441 folios, f. 397, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Sixième cartulaire de Saint-Étienne de Dijon (1662), Archives départementales de la Côte-d'Or, Cart. 30 (G 133), 441 folios, f. 397, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Engineering biosensors for the detection of unfolded protein response in saccharomyces cerevisiae
Creators: name: Peng, Kai
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: The unfolded protein response (UPR) is activated when the protein folding capacity of the endoplasmic reticulum (ER) is overwhelmed by the accumulation of unfolded proteins inside the ER lumen. In S. cerevisiae, the UPR facilitates the up-and down-regulations of a collection of UPR target genes via the IRE1/HAC1 dependent signalling pathway to bring the ER back to homeostasis. In the application of S. cerevisiae as a cell factory for producing heterologous proteins,low levels of target protein secretion are often associated with the up-regulation of UPR. In this study we constructed nine UPR biosensors using the putative promoter sequences of nine UPR genes including DER1, ERO1, EUG1, HAC1, KAR2, PDI1, PMT2, SEC12 andOST2as sensors, and green fluorescent protein as reporter. We have evaluated these biosensors in their capacities to detect the activation and different levels of UPR, and found that the sensors incorporating the DER1and ERO1 putative promoter sequences gave the best responses across a range of UPR induction levels. This study highlighted the prospect of providing a real-time and high-throughput detection of unfolded protein induced stress and its concomitant influences on protein secretion.
Generalized quasi-topological gravity
Creators: name: Hennigar, Robie A.
name: Kubiznak, David
name: Mann, Robert B.
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We construct the most general, to cubic order in curvature, theory of gravity whose (most general) static spherically symmetric vacuum solutions are fully described by a single field equation. The theory possess the following remarkable properties: i) it has a well-defined Einstein gravity limit ii) it admits `Schwarzschild-like' solutions characterized by a single metric function iii) on maximally symmetric backgrounds it propagates the same degrees of freedom as Einstein's gravity iv) Lovelock and quasi-topological gravities, as well as the recently developed Einsteinian cubic gravity [ArXiv:1607.06463] in four dimensions, are recovered as special cases. We perform a brief analysis of asymptotically flat black holes in this theory and study their thermodynamics.
description: 19 pages, 1 figure
Additional file 1: of Influence of demographic changes on the impact of vaccination against varicella and herpes zoster in Germany â a mathematical modelling study
Creators: name: Horn, Johannes
name: Damm, Oliver
name: Greiner, Wolfgang
name: Hengel, Hartmut
name: Kretzschmar, Mirjam
name: Siedler, Anette
name: Ultsch, Bernhard
name: Weidemann, Felix
name: Wichmann, Ole
name: AndrĂŠ Karch
name: Mikolajczyk, Rafael
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Influence of demographic changes on the impact of vaccination against varicella and herpes zoster in Germany â a mathematical modelling study (technical appendix). (DOCX 1750 kb)
Additional file 8 of Genome-wide association study of the candidate genes for grape berry shape-related traits
Creators: name: Zhang, Chuan
name: Cui, Liwen
name: Fang, Jinggui
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 8: Table S4. Total variance explained.
Geostatistical methods for modelling spatially aggregated data
Creators: name: Johnson, Olatunji
Publisher: name: Lancaster University
Year: 2020

description: Spatially aggregated epidemiological data is nowadays increasingly common because of ethical concern of data use as well as preservation of patient confidentiality. They are typically presented either as the count of disease cases or as an average measurement from districts partitioning a study region. In most cases, the partitioning is based on administrative convenience rather than information about the aetiology of any disease or public health problem. While inference for spatially aggregated data commonly make use of model that assumes a spatially discrete variation, we argue that a spatially continuous model should be considered when there is a scientific justification for its use, especially when the underlying generating process of the disease outcome is hypothesised to behave in a spatially continuous manner. In this thesis, we consider geostatistical methods as a framework that can be used to analyse spatially aggregated data. This thesis is a series of papers, two methodological and one public health application. In the first methodological paper, we developed a computationally efficient discrete approximation to log-Gaussian Cox process (LGCP) models for the analysis of spatially aggregated disease count data. We compare the predictive performance of our modelling approach with LGCP through a simulation study and an application to primary biliary cirrhosis incidence data in Newcastle-Upon-Tyne, UK. Our results suggest that when disease risk is assumed to be a spatially continuous process, the proposed approximation to LGCP provides reliable estimates of disease risk both on spatially continuous and aggregated scales. In the second methodological paper, We developed a model-based geostatistical approach that allows us to model the relationship between the Life expectancy at birth (LEB) and the index of multiple deprivation (IMD), when these are available over different partitions of the study region. We found that the effect of IMD on LEB is higher for males than for females. We show that our proposed model-based geostatistical approach does not only provide solution to any form of misalignment problem but also allows for spatially continuous inferences. In the third application paper, we developed a spatio-temporal model for monthly Chronic Obstructive Pulmonary Disease (COPD) emergency admissions data in South Cumbria and North Lancashire, UK, 2012-2018. We assess the relative contribution of socio-economic and environmental variables for forecasting COPD emergency admissions. In addition, we develop an early warning system that triggers an alarm whenever COPD emergency admissions exceeds a predefined incidence thresholds. The result of our analysis can potentially help NHS Morecambe Bay Clinical Commissioning Group stakeholders to define areas to target early intervention as well as inform resource allocation for healthcare system so that its limited resources can be used to maximum effect.
Estimation of the utilities of attributes of intravenous iron infusion treatment for patients with iron-deficiency anemia: a conjoint analysis in Japan
Creators: name: Takeshima, Tomomi
name: Ha, Chise
name: Iwasaki, Kosuke
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: This study aimed to estimate the utility values of the factors associated with intravenous (IV) iron infusion treatment in Japanese patients with iron-deficiency anemia (IDA) from the patient’s perspective. A conjoint analysis based on online survey data was conducted in May 2022 (registration number: UMIN000047756). Respondents in the main group were selected from the general population (20–69 years). Seven attributes were included in this analysis: waiting time before receiving an IV infusion, pain due to IV infusion, time required for IV infusion, number of IV infusions required to achieve treatment effect, frequency of hypophosphatemia as a side effect of IV infusion, frequency of skin discoloration by the drug solution, and out-of-pocket cost for one IV infusion visit. The utility of each level for each attribute was estimated using a logistic regression model as the difference from non-treatment. The responses were collected from 1,026 people. The utilities decreased with higher pain (−0.189 for pain level of 3.05), longer time for the IV infusion (−0.145 or −0.212 for 5 or 15 min), greater number of required IV infusions (−0.773 or −1.899 for 3 or 25 times), and higher frequency of adverse events (−0.373 or −0.385 for 13.0% or 14.2% of hypophosphatemia incidences; −0.502 for 2.3% of skin discoloration per one infusion). Since this study was based on an online survey, the reliability of the results depends on whether the respondents understood the questions accurately. Further, the respondents were selected from an online panel, potentially affecting finding generalizability. The results indicate that utilities differ depending on the factors associated with IV iron infusion treatment. The findings of this study may be useful for informing future treatments or improving current treatment regimes, supporting the achievement of complete iron repletion for Japanese patients with IDA.
Environmental correlates of temporal variation in the diet of Australian fur seals
Creators: name: Kliska, Kimberley
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Long term systematic monitoring of the diet of large marine predators can be an effective approach to detect and understand changes in ecosystems vulnerable to environmental change. This study quantified seasonal and annual changes in the frequency of occurrence (%FO) of prey items in the diet of Australian fur seals (Arctocephalus pusillus doriferus) in Bass Strait from 1998 to 2014. Using hard part analysis, 71 prey species were identified, with combinations of 8 main species found in more than 70% of the samples. Otolith measurements suggest Australian fur seals consumed predominantly juvenile fishes. I investigated correlations between environmental variables and %FO using generalised additive models. Southern Oscillation Index (SOI) correlated with the %FO of red cod Pseudophycis bachus, pilchard Sardinops sagax and jack mackerel Trachurus declivis. Positive correlations relating to El Niño conditions were found for both red cod and pilchard and correlation with neutral SOI was found for jack mackerel. Correlations identified between long-term environmental change and prey of marine predators suggests large-scale processes can influence prey assemblages at various trophic levels in Bass Strait.
Multi-Personality Partitioning for Heterogeneous Systems
Creators: name: Gregerson, Anthony
name: Chadha, Aman
name: Morrow, Katherine
Publisher: name: arXiv
Year: 2017
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: Data Structures and Algorithms (cs.DS)
subject: FOS: Computer and information sciences

description: Design flows use graph partitioning both as a precursor to place and route for single devices, and to divide netlists or task graphs among multiple devices. Partitioners have accommodated FPGA heterogeneity via multi-resource constraints, but have not yet exploited the corresponding ability to implement some computations in multiple ways (e.g., LUTs vs. DSP blocks), which could enable a superior solution. This paper introduces multi-personality graph partitioning, which incorporates aspects of resource mapping into partitioning. We present a modified multi-level KLFM partitioning algorithm that also performs heterogeneous resource mapping for nodes with multiple potential implementations (multiple personalities). We evaluate several variants of our multi-personality FPGA circuit partitioner using 21 circuits and benchmark graphs, and show that dynamic resource mapping improves cut size on average by 27% over static mapping for these circuits. We further show that it improves deviation from target resource utilizations by 50% over post-partitioning resource mapping.
description: International Conference on Field-Programmable Technology (ICFPT), Kyoto Research Park, Japan, Dec. 9-11, 2013. hardware design; hardware architecture; cad; computer aided design; IC design; integrated circuit design; partitioning algorithms; field programmable gate arrays; benchmark testing; heuristic algorithms; resource management; dynamic scheduling; digital signal processing
MOESM1 of Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative
Creators: name: Scott, Jan
name: Hidalgo-Mazzei, Diego
name: Strawbridge, Rebecca
name: Young, Allan
name: Resche-Rigon, Matthieu
name: Etain, Bruno
name: Andreassen, Ole
name: Bauer, Michael
name: Bennabi, Djamila
name: Blamire, Andrew
name: Boumezbeur, Fawzi
name: Brambilla, Paolo
name: Cattane, Nadia
name: Cattaneo, Annamaria
name: Chupin, Marie
name: Coello, Klara
name: Cointepas, Yann
name: Colom, Francesc
name: Cousins, David
name: Dubertret, Caroline
name: Duchesnay, Edouard
name: Ferro, Adele
name: Garcia-Estela, Aitana
name: Goikolea, Jose
name: Grigis, Antoine
name: Haffen, Emmanuel
name: HĂ¸egh, Margrethe
name: Jakobsen, Petter
name: Kalman, Janos
name: Kessing, Lars
name: Klohn-Saghatolislam, Farah
name: Lagerberg, Trine
name: LandĂŠn, Mikael
name: Lewitzka, Ute
name: Lutticke, Ashley
name: Mazer, Nicolas
name: Mazzelli, Monica
name: Mora, Cristina
name: Muller, Thorsten
name: Mur-Mila, Estanislao
name: Oedegaard, Ketil
name: Oltedal, Leif
name: PĂĽlsson, Erik
name: Papadopoulos Orfanos, Dimitri
name: Papiol, Sergi
name: Perez-Sola, Victor
name: Reif, Andreas
name: Ritter, Philipp
name: Rossi, Roberto
name: Schulze, Thomas
name: Senner, Fanny
name: Smith, Fiona
name: Squarcina, Letizia
name: Steen, Nils
name: Thelwall, Pete
name: Varo, Cristina
name: Vieta, Eduard
name: Vinberg, Maj
name: Wessa, Michele
name: Westlye, Lars
name: Bellivier, Frank
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Mental Health

description: Additional file 1: Appendix S1. Country and location of centres involved in R-LiNK.
MOESM4 of Hiss and snort call types of wild-living giraffes Giraffa camelopardalis: acoustic structure and context
Creators: name: Volodina, Elena
name: Volodin, Ilya
name: Chelysheva, Elena
name: Frey, Roland
Publisher: name: figshare
Year: 2018
Subjects: subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 4: Table S2. Indicating call type, nasal/oral vocal emission and acoustic characteristics of vigilance-related vocalizations across Ruminantia.
Head mounted display architectures for 3D augmented reality
Creators: name: Pryn, Matthew James
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Augmented reality
AR
3D display
Head mounted display
HMD

description: Augmented reality (AR) is the enhancement of our perception of the world around us. It promises the ability to simultaneously interact with a virtual environment and real objects, providing an intuitive method to interact with data. However, AR displays must be lightweight and compact, and be able to display bright, high-resolution 3D images. Current AR displays are limited by bulky-form factors with a limited field of view (FOV), and the inability to display high quality 3D images without introducing side effects such as nausea and eyestrain. In the first part of this thesis an afocal Maxwellian display is analysed and modelled, the small eyebox limitation examined and a solution proposed. A prototype head mounted display unit was constructed as a demonstration. The display performance was analysed objectively and subjectively, and found to perform well over a wide accommodation range. However, the system is mechanically complicated to provide for a large IPD demographic, and the implementation of the eyebox expansion is too limited. An alternative curved reflector system was proposed to reduce weight, increase FOV, and increase the eyebox. The final part of this research examines waveguides as an AR display technology. The limitations of current systems are evaluated, and a novel switchable waveguide architecture proposed where light can be selectively directed towards the eye to form an image time sequentially. This enables higher quality images, with a wider FOV and increased efficiency, from a more transparent waveguide. A liquid crystal diffraction grating is developed as a switching element with a simulated diffraction efficiency of 20% and a geometry optimised for easy industrial manufacture. The possibility for such a system to include an integrated lens function is also considered, and an 80° FOV design presented.
description: Head mounted display work performed in partnership with Huawei Technologies GmbH
Crafting soft power in Thailand
Creators: name: Praditsilp, Wasin
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Despite international scholars’ pervasive research on national soft power, scant attention has been given to Thai soft power. Existing Thai research examines impact of foreign countries' soft power diplomacy toward Thai society when only one thesis in 2015 studies the Thai government’s soft power development role on Thai film industry. The government draws on intangible (processes and values) and tangible (products) cultural heritage outputs of creative industries to enhance national development and national image through its cultural export policies. This study elucidates soft power intentions incorporated in Thai cultural export and reflects on future soft power potential. The research objectives are (1 ) to identify the soft power intentions incorporated in cultural export policy; (2) to identify civic motivations of Thai stakeholders; (3) to examine the soft power dimensions of “Thainess” in cultural products and (4) to find out the future soft power potential of Thai cultural export. The study draws on the literatures of creative industries and International Communication. Thai silk industry was selected as a case study. A mixed-methods approach was adopted with in-depth interviews and Delphi technique with silk industry-related intermediate experts from government, business and civil society sectors. Fifteen intermediate experts from the government, silk-related businesses and think tanks were interviewed on soft power intentions in cultural export policy. Five Jim Thompson employees were interviewed on soft power intentions in creative industries management. Five weavers were interviewed on soft power intentions in the silk industry and products. Five foreign visitors were interviewed on views about Thai silk products. Deductively and inductively derived individual frames were reported. Nine Thai heterogenous experts forecasted cultural export’s future potential in the Delphi technique – round one was inductive. Analysis of the interviews revealed frames of virtuosity of craftsmanship and beautiful culture for national economic and image enhancement when the visitors reflected on soft power dimensions. The stakeholders’ gratefulness of their nation as a value-based civic virtue played roles in cultural export policy and practice. The Delphi technique reaffirmed the emphasis of traditional cultural products as cultural export drivers when the experts concerned its limitations on international stages and recommended that stakeholders draw on the use of pop/contemporary culture. This study is part of growing soft power research in Asia using largely untapped Thai cultural data. It will contribute to creative industries policy making, support Thai soft power operation and act as a bridge to future research on topics of creative industries and soft power for Thai and international scholarship.
Additional file 2: of The function of tcf3 in medaka embryos: efficient knockdown with pePNAs
Creators: name: Doenz, Gerlinde
name: Dorn, Sebastian
name: Aghaallaei, Narges
name: Baubak Bajoghli
name: Riegel, Elisabeth
name: Aigner, Michaela
name: Bock, Holger
name: Werner, Birgit
name: Lindhorst, Thomas
name: Czerny, Thomas
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Developmental Biology

description: Gro/Tle dependence of 1 tcf3 in gain-of-function experiments. Embryos at the 1-2 cell stage were co-injected with 40 ng/μl of the indicated gfp:HSE:Tcf3 constructs. Heat treatment (10 min, 43.5 °C) was applied at stage 14. (A) Statistical overview of the phenotype distribution. Whole mount in situ hybridization experiments for rx2 were performed on embryos at stage 21. (B) dorsal view of a stage 31 embryo with anterior at the top, (C) lateral view with anterior at the left. Arrowheads indicate ectopic otic vesicles, the arrow points to the endogenous otic vesicle. Scale bar 100 μm; B and C. (PDF 10028 kb)
Design and applications of multi-channel directional couplers
Creators: name: McCosker, Ravi James
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: The research in this thesis presents the analysis and design of multi-channel directional coupler structures for applications in optical sensing and electro-optic devices. The structures are analysed using supermodes and a potential limitation is identified with the discovery of the phenomenon of partial image revivals. A detailed analysis is presented along with one possible exploitation of this phenomenon with the design of a compact wavelength division multiplexer. The outcomes of the research include: i) an evanescent field optical sensor is designed using the multi-channel directional coupler structure; the design is based on the idea that the analyte to be measured infiltrates the spacing between the coupled waveguides so that the sensor can exploit the exponential dependence of the coupling on the analyte refractive index; ii) an optical chemical sensor is designed that uses silicon slot waveguides; the sensor exploits the high confinement of light in the slots, whilst retaining the exponential dependence of the coupling on the analyte refractive index; iii) discovery of the differential multi-channel directional coupler structure; and the design of a more efficient optical chemical sensor using this structure; iv) a multichannel directional coupler refractive index sensor is design in fiber, i.e. as a dual-core microstructured optical fiber; v) a compact wavelength division multiplexer for fluorescence sensing is designed; vi) electro-optic devices including an optical electric field sensor, switch and modulators are design using the multi-channel directional coupler structure and recent electro-optic materials.
Monodromy of the $SL(n)$ and $GL(n)$ Hitchin fibrations
Creators: name: Baraglia, David
Publisher: name: arXiv
Year: 2016
Subjects: subject: Algebraic Geometry (math.AG)
subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: Primary 14H60, 53C07, Secondary 14H70, 14D05

description: We compute the monodromy of the Hitchin fibration for the moduli space of $L$-twisted $SL(n,\mathbb{C})$ and $GL(n,\mathbb{C})$-Higgs bundles for any $n$, on a compact Riemann surface of genus $g>1$. We require the line bundle $L$ to either be the canonical bundle or satisfy $deg(L) > 2g-2$. The monodromy group is generated by Picard-Lefschetz transformations associated to vanishing cycles of singular spectral curves. We construct such vanishing cycles explicitly and use this to show that the $SL(n,\mathbb{C})$ monodromy group is a {\em skew-symmetric vanishing lattice} in the sense of Janssen. Using the classification of vanishing lattices over $\mathbb{Z}$, we completely determine the structure of the monodromy groups of the $SL(n,\mathbb{C})$ and $GL(n,\mathbb{C})$ Hitchin fibrations. As an application we determine the image of the restriction map from the cohomology of the moduli space of Higgs bundles to the cohomology of a non-singular fibre of the Hitchin fibration.
description: 32 pages
The ATLASGAL survey: The sample of young massive cluster progenitors
Creators: name: Csengeri, T.
name: Bontemps, S.
name: Wyrowski, F.
name: Megeath, S. T.
name: Motte, F.
name: Sanna, A.
name: Wienen, M.
name: Menten, K. M.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The progenitors of high-mass stars and clusters are still challenging to recognise. Only unbiased surveys, sensitive to compact regions of high dust column density, can unambiguously reveal such a small population of particularly massive and cold clumps. Here we study a flux limited sample of compact sources from the ATLASGAL survey to identify a sample of candidate progenitors of massive clusters in the inner Galaxy. Sensitive mid-infrared data at 21-24 $μ$m from the WISE and MIPSGAL surveys were explored to search for embedded objects, and complementary spectroscopic data were used to investigate their stability and star formation activity. Based on such ancillary data we identify an unbiased sample of infrared-quiet massive clumps in the Galaxy that potentially represent the earliest stages of massive cluster formation. An important fraction of this sample consists of sources that have not been studied in detail before. Comparing their properties to clumps hosting more evolved embedded objects, we find that they exhibit similar physical properties in terms of mass and size, suggesting that infrared-quiet massive clumps are not only capable of forming high-mass stars, but likely also follow a single evolutionary track leading to the formation of massive clusters. The majority of the sources are not in virial-equilibrium, suggesting collapse on the clump scale. This is in line with the low number of infrared-quiet massive clumps and earlier findings that star formation, in particular for high-mass objects is a fast, dynamic process. We propose a scenario in which massive clumps start to fragment and collapse before their final mass is accumulated indicating that strong self-gravity and global collapse is needed to build up rich clusters and the most massive stars.
description: Accepted by A&A (version after language editing). The abstract is shortened to fit the ArXiv format, and the figure quality is strongly degraded due to the size limitations
The budget impact of utilizing the Oncotype DX Breast Recurrence Score test from a US healthcare payer perspective
Creators: name: Berdunov, Vladislav
name: Laws, Ewan
name: Carter, Gebra Cuyun
name: Luo, Roger
name: Russell, Christy
name: Campbell, Sara
name: Force, Jeremy
name: Abdou, Yara
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Science Policy

description: The Oncotype DX Breast Recurrence Score test is used to estimate distant recurrence risk of hormone receptor-positive (HR+) and human epidermal growth factor receptor 2-negative (HER2–) early-stage breast cancer and inform decisions on the use of adjuvant chemotherapy. A model-based budget impact analysis compared the Oncotype DX test in combination with clinical–pathological risk against using clinical–pathological risk alone for HR+/HER2– node-negative (N0) and node-positive (N1; 1–3 axillary lymph nodes) early-stage breast cancer patients. Test and medical costs associated with treatment of breast cancer were assessed through a US healthcare payer perspective. Distributions of patients by Recurrence Score result and distant recurrence probabilities with chemo-endocrine and endocrine therapy were derived from the TAILORx (N0) and RxPONDER (N1) trials. Changes in budget impact were evaluated over a 5-year horizon for a 1,000,000-member hypothetical health plan. With the Oncotype DX test, there was an incremental budget impact of $261,067 (per member per month (PMPM): $0.004), in the N0 population, and $56,143 (PMPM: $0.001) in the N1 population over the 5-year period. The largest budget impact reduction in the N0 population was attributed to reduced breast cancer recurrence costs (incremental: −$633,457, PMPM: −$0.011), while chemotherapy sparing reduced costs in the N1 population (incremental: −$94,884, PMPM: −$0.002). The clinical benefit of using the Oncotype DX test to inform adjuvant chemotherapy decisions has been shown in multiple randomized controlled trials. This analysis demonstrated that while using the Oncotype DX test to inform adjuvant chemotherapy decisions may slightly increase US healthcare costs over an initial 5-year time horizon (driven by a cost increase in the first year with cost savings reflected in remaining 4 years), there is significant scope for cost savings when assessing beyond this period due to avoided downstream costs of distant recurrence and long-term chemotherapy adverse events. PMPM costs also remain low across all populations examined, demonstrating a close-to-neutral budget impact.
Sparse Reduced Rank Huber Regression in High Dimensions
Creators: name: Tan, Kean Ming
name: Sun, Qiang
name: Witten, Daniela
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Cell Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer

description: We propose a sparse reduced rank Huber regression for analyzing large and complex high-dimensional data with heavy-tailed random noise. The proposed method is based on a convex relaxation of a rank- and sparsity-constrained nonconvex optimization problem, which is then solved using a block coordinate descent and an alternating direction method of multipliers algorithm. We establish nonasymptotic estimation error bounds under both Frobenius and nuclear norms in the high-dimensional setting. This is a major contribution over existing results in reduced rank regression, which mainly focus on rank selection and prediction consistency. Our theoretical results quantify the tradeoff between heavy-tailedness of the random noise and statistical bias. For random noise with bounded (1+δ)th moment with δ∈(0,1), the rate of convergence is a function of δ, and is slower than the sub-Gaussian-type deviation bounds; for random noise with bounded second moment, we obtain a rate of convergence as if sub-Gaussian noise were assumed. We illustrate the performance of the proposed method via extensive numerical studies and a data application. Supplementary materials for this article are available online.
A One-Field Monolithic Fictitious Domain Method for Fluid-Structure Interactions
Creators: name: Wang, Yongxing
name: Jimack, Peter
name: Walkley, Mark
Publisher: name: arXiv
Year: 2016
Subjects: subject: Computational Engineering, Finance, and Science (cs.CE)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: In this article, we present a one-field monolithic fictitious domain (FD) method for simulation of general fluid-structure interactions (FSI). One-field means only one velocity field is solved in the whole domain, based upon the use of an appropriate L2 projection. Monolithic means the fluid and solid equations are solved synchronously (rather than sequentially). We argue that the proposed method has the same generality and robustness as FD methods with distributed Lagrange multiplier (DLM) but is significantly more computationally efficient (because of one-field) whilst being very straightforward to implement. The method is described in detail, followed by the presentation of multiple computational examples in order to validate it across a wide range of fluid and solid parameters and interactions.
description: arXiv admin note: substantial text overlap with arXiv:1608.04998
Hairy black holes in cubic quasi-topological gravity
Creators: name: Dykaar, Hannah
name: Hennigar, Robie A.
name: Mann, Robert B.
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We construct a class of five dimensional black hole solutions to cubic quasi-topological gravity with conformal scalar hair and study their thermodynamics. We find these black holes provide the second example of black hole $λ$-lines: a line of second order (continuous) phase transitions, akin to the fluid/superfluid transition of $^4$He. Examples of isolated critical points are found for spherical black holes, marking the first in the literature to date. We also find various novel and interesting phase structures, including an isolated critical point occurring in conjunction with a double reentrant phase transition. The AdS vacua of the theory are studied, finding ghost-free configurations where the scalar field takes on a non-zero constant value, in notable contrast to the five dimensional Lovelock case.
description: 29 pages, 12 figures
title: ADCO, Ordre cistercien et abbaye de Cîteaux : comptes pour l'ordre (1337-1347), comptes du boursier (1377-1402) (11 H 1160), f. 00045
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2017
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: comptes
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Ordre cistercien et abbaye de Cîteaux : comptes pour l'ordre (1337-1347), comptes du boursier (1377-1402), Archives départementales de la Côte-d'Or, (11 H 1160). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Ordre cistercien et abbaye de Cîteaux : comptes pour l'ordre (1337-1347), comptes du boursier (1377-1402), Archives départementales de la Côte-d'Or, (11 H 1160), f. 00045, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Additional file 1: of Substitution of care for chronic heart failure from the hospital to the general practice: patientsâ perspectives
Creators: name: J. Wildeboer
name: A. Van De Ven
name: D. De Boer
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Topic list that was used during the semi-structured interviews. (DOCX 14Â kb)