title: ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð½Ð¾Ð²ÑÑ ÑÑÐ½ÐºÑÐ¸Ð¾Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÑ Ð² Ð¿Ð¾Ð»Ð¾Ð¶ÐµÐ½Ð¸Ð¸ Ð¡-30 ÑÐµÑÐ¿ÐµÐ½Ð¾Ð¸Ð´Ð¾Ð² Ð»ÑÐ¿Ð°Ð½Ð¾Ð²Ð¾Ð³Ð¾ ÑÑÐ´Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: The study of the biological activity of new functionalized in the position of c-30 terpenoids of the lupan series
Creators: name: Ð¡ÑÑÐºÐ°Ð»Ð¾Ð²Ð°, ÐÐ°ÑÐ¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: ÐÐ¸Ð¾ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸Ñ
Ñ Ð¸Ð¼ÐµÑÐ½ÑÐµ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ñ
Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ°Ñ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ
ÑÐ¾Ð½ÐºÐ¸Ð¹ Ð¾ÑÐ³Ð°Ð½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ¸Ð½ÑÐµÐ·
Ð·Ð°ÑÐ¸ÑÐ° ÑÐ°ÑÑÐµÐ½Ð¸Ð¹
chimeric compounds
biological activity
synthesis
plants protection

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description: The subject of graduate qualification work is: "The study of the biological activity of new functionalized in the position of c-30 terpenoids of the lupan series". This work is devoted to the study of the biological activity of new functionalized terpenoids of the lupan series obtained by modifying betulin at the position of C30 fragments of eugenol and phenylisoxazoline nucleus.Â Tasks that were solved during the research: 1. Isolate betulin from natural raw materials, synthesize new chimeric derivatives containing fragments of eugenol and phenyloxazoline by its chemical modification; 2. To investigate the available set of substances for antibacterial, antiradical, attrative/antifidant, growth-stimulating activity and acute toxicity; 3. To carry out a comparative analysis of the biological activity profiles of the initial compounds and their derivatives. The work was carried out based on the Laboratory of phytotoxicology and biotechnology of the FGBNU VISR, where a significant part of the factual material was collected. Based on the products of plant biosynthesis â betulin triterpenoid and eugenol phenol, methods for obtaining new chimeric compounds with an isoxazoline fragment in their composition have been developed. With the help of a wide range of bioassays for the available starting compounds and products of their chemical modification, profiles of their biological activity were collected and analyzed. A comparative analysis of the results of bioassays showed significant differences between the selectivity of the action of these compounds in relation to several test objects used.