cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses
Creators: name: Ye, Zhengmao
name: Iocca, Heather A.
name: Ting, Jenny P.Y.
name: Miller, Stephen D.
name: Huang, Max
name: Schneider, Monika
name: Gris, Denis
name: Wen, Haitao
name: Craven, Robin R.
name: Gris, Pavel
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The interplay between innate and adaptive immunity is important in multiple sclerosis (MS). The inflammasome complex, which activates caspase-1 to process pro–IL-1β and pro–IL-18, is rapidly emerging as a pivotal regulator of innate immunity, with nucleotide-binding domain, leucine-rich repeat containing protein family, pyrin domain containing 3 (NLRP3) (cryopyrin or NALP3) as a prominent player. Although the role of NLRP3 in host response to pathogen associated molecular patterns and danger associated molecular patterns is well documented, its role in autoimmune diseases is less well studied. To investigate the role of NLRP3 protein in MS, we used a mouse model of MS, experimental autoimmune encephalomyelitis (EAE). Nlrp3 expression was elevated in the spinal cords during EAE, and Nlrp3−/− mice had a dramatically delayed course and reduced severity of disease. This was accompanied by a significant reduction of the inflammatory infiltrate including macrophages, dendritic cells, CD4, and CD8+ T cells in the spinal cords of the Nlrp3−/− mice, whereas microglial accumulation remained the same. Nlrp3−/− mice also displayed improved histology in the spinal cords with reduced destruction of myelin and astrogliosis. Nlrp3−/− mice with EAE produced less IL-18, and the disease course was similar to Il18−/− mice. Furthermore, Nlrp3−/− and Il18−/− mice had similarly reduced IFN-γ and IL-17 production. Thus, NLRP3 plays a critical role in the induction of the EAE, likely through effects on capase-1–dependent cytokines which then influence Th1 and Th17.
Low-frequency internal friction (LFIF) as express-method for identification of cryocrystals in pores of the solids
Creators: name: Erenburg, A. I.
name: Zakharov, A. Yu.
name: Leont'eva, A. V.
name: Prokhorov, A. Yu.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences
subject: 82B30, 82D25

description: We show that studying of low-frequency internal friction (LFIF) of solid samples at low temperatures allows determining the presence of various gases absorbed, for some reasons, in pores and caverns of the solids. The gases come over to a solid state (cryocrystals) and exist in the pores under corresponding thermodynamic conditions giving an additional contribution to the LFIF spectra. The spectra reflect the special points of the gases (temperatures of melting or phase transitions). This information gives a real opportunity for identification of gas in the matrix, i.e. the studied solids. This may be of great importance for investigations of cosmic or geological samples, for instance, asteroids, meteorites, rock formations, etc. The LFIF method allows identification of gas media surrounding the studied sample.
description: 14 pages, 8 figures, 39 refs
What works best? A comparative analysis of nudges, boosts, thinks and nudge pluses in sustainably altering dietary choices
Creators: name: Banerjee, Sanchayan
name: John, Peter
name: Galizzi, Matteo
name: Mourato, Susana
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Public Affairs, Public Policy and Public Administration
subject: Economics
subject: Environmental Studies
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: Other Social and Behavioral Sciences

description: The project involves an online experiment testing twelve treatments (variants of nudges, thinks, boosts and nudge pluses) in promoting the uptake of environmentally sustainable diets.
What works best? A comparative analysis of nudges, boosts, thinks and nudge pluses in sustainably altering dietary choices
Creators: name: Banerjee, Sanchayan
name: John, Peter
name: Galizzi, Matteo
name: Mourato, Susana
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Economics
subject: Environmental Studies
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: The project involves an online experiment testing twelve treatments (variants of nudges, thinks, boosts and nudge pluses) in promoting the uptake of environmentally sustainable diets.
EXISTENCE D'ARTHROTARDIGRADES SEMI-BENTHIQUES DE GENRES NOUVEAUX DE LA SOUS-FAMILLE DES STYRACONYXINAE SU BEAM. NOV.
Creators: name: KRISTENSEN, Reinhardt Mobjerg
name: RENAUD-MORNANT, Jeanne
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1983

Abstract
Protective Endogenous Cyclic Adenosine 5'-Monophosphate Signaling Triggered by Pemphigus Autoantibodies
Creators: name: Waschke, Jens
name: Rubenstein, David S.
name: Schmidt, Enno
name: Vielmuth, Franziska
name: Spindler, Volker
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Pemphigus vulgaris (PV) is an autoimmune skin disease mediated by autoantibodies directed against the cadherin-type cell adhesion molecules desmoglein (Dsg) 3 and Dsg1 and is characterized by loss of keratinocyte cohesion and epidermal blistering. Several intracellular signaling pathways, such as p38MAPK activation and RhoA inhibition, have been demonstrated to be altered following autoantibody binding and to be causally involved in loss of keratinocyte cohesion. In this paper, we demonstrate that cAMP-mediated signaling completely prevented blister formation in a neonatal pemphigus mouse model. Furthermore, elevation of cellular cAMP levels by forskolin/rolipram or β receptor agonist isoproterenol blocked loss of intercellular adhesion, depletion of cellular Dsg3, and morphologic changes induced by Ab fractions of PV patients (PV-IgG) in cultured keratinocytes. Incubation with PV-IgG alone increased cAMP levels, indicating that cAMP elevation may be a cellular response pathway to strengthen intercellular adhesion. Our data furthermore demonstrate that this protective pathway may involve protein kinase A signaling because protein kinase A inhibition attenuated recovery from PV-IgG–induced cell dissociation. Finally, cAMP increase interfered with PV-IgG–induced signaling by preventing p38MAPK activation both in vitro and in vivo. Taken together, our data provide insights into the cellular response mechanisms following pemphigus autoantibody binding and point to a possible novel and more specific therapeutic approach in pemphigus.
Thermodynamics of sustaining gases in the roughness of submerged superhydrophobic surfaces
Creators: name: Patankar, Neelesh A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Rough surfaces submerged in a liquid can remain almost dry if the liquid does not fully wet the roughness and gases are sustained in roughness grooves. Such partially dry surfaces can help reduce drag or enhance boiling. Gases sustained in roughness grooves would be composed of air and the vapor phase of the liquid itself. The thermodynamics of sustaining vapor was considered in a prior work [Patankar, Soft Matter, 2010, 6:1613]. Here, the thermodynamics of sustaining gases (e.g. air) is considered. Governing equations are presented along with a solution methodology to determine a critical condition to sustain gases. The critical roughness scale to sustain gases is estimated for different degrees of saturation of gases dissolved in the liquid. It is shown that roughness spacings of less than a micron are essential to sustain gases on surfaces submerged in water at atmospheric pressure. This is consistent with prior empirical data.
description: 15 pages, 6 figures
Feeding habits of Sparus aurata (Sparidae) from the Gulf of Gabes (central Mediterranean)
Creators: name: HADJ TAIEB, Aymen
name: SLEY, Ayda
name: GHORBEL, Mohamed
name: JARBOUI, Othman
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2013

description: The dietary habits of Sparus aurata (Sparidae) ranging from 10.1 to 35 cm in total length were studied in the Gulf of Gabes (South of the Tunisia, Center of the Mediterranean), with respect to sex, fish size and season, using the index of relative importance (IRI). On 1065 stomachs examined, 605 were empty, which corresponds to a vacuity index (%VI) of 56.81%. This index differed significantly across time. Sparus aurata eats mainly arthropods (%IRI = 51.71%) and molluscs (%IRI = 43.74%). This species is carnivorous and opportunistic. The qualitative and quantitative analysis of the diet allowed significant differences between males and females, through the various size-classes and among the seasons.
(1830) Ann Kean
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Toxin-Coupled MHC Class I Tetramers Can Specifically Ablate Autoreactive CD8+ T Cells and Delay Diabetes in Nonobese Diabetic Mice
Creators: name: Young, Ellen F.
name: Kepler, Thomas B.
name: Tisch, Roland M.
name: Stevens, Rosemary
name: Frelinger, Jeffrey A.
name: Buntzman, Adam S.
name: Vincent, Benjamin G.
name: Hess, Paul R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: There is compelling evidence that self reactive CD8+ T cells are a major factor in development and progression of Type 1 diabetes in animals and humans. Hence, great effort has been expended to define the specificity of autoimmune CD8+ T cells, and to alter their responses. Much work has focused on tolerization of T cells using proteins or peptides. A weakness in this approach is residual autoreactive T cells may be activated and exacerbate disease.
An Anti-Inflammatory Role for Carbon Monoxide and Heme Oxygenase-1 in Chronic Th2-Mediated Murine Colitis
Creators: name: Otterbein, Leo E.
name: Kobayashi, Taku
name: Russo, Steven M.
name: Plevy, Scott E.
name: Matsuoka, Katsuyoshi
name: Hegazi, Refaat A.
name: Li, Fengling
name: Sheikh, Shehzad Z.
name: Onyiah, Joseph C.
name: Sepulveda, Antonia R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Cigarette smoking is a significant environmental factor in the human inflammatory bowel diseases, remarkably, conferring protection in ulcerative colitis. We previously demonstrated that a prominent component of cigarette smoke, CO, suppresses Th17-mediated experimental colitis in IL-10−/− mice through a heme oxygenase (HO)-1–dependent pathway. In this study, homeostatic and therapeutic effects of CO and HO-1 were determined in chronic colonic inflammation in TCR-α–deficient (−/−) mice, in which colitis is mediated by Th2 cytokines, similar to the cytokine milieu described in human ulcerative colitis. TCRα−/− mice exposed to CO or treated with the pharmacologic HO-1 inducer cobalt protoporphyrin demonstrated amelioration of active colitis. CO and cobalt protoporphyrin suppressed colonic IL-1β, TNF, and IL-4 production, whereas IL-10 protein secretion was increased. CO induced IL-10 expression in macrophages and in vivo through an HO-1–dependent pathway. Bacterial products regulate HO-1 expression in macrophages through MyD88- and IL-10–dependent pathways. CO exposure and pharmacologic HO-1 induction in vivo resulted in increased expression of HO-1 and IL-10 in CD11b+ lamina propria mononuclear cells. Moreover, induction of the IL-10 family member IL-22 was demonstrated in CD11b− lamina propria mononuclear cells. In conclusion, CO and HO-1 induction ameliorated active colitis in TCRα−/− mice, and therapeutic effects correlated with induction of IL-10. This study provides further evidence that HO-1 mediates an important homeostatic pathway with pleiotropic anti-inflammatory effects in different experimental models of colitis and that targeting HO-1, therefore, is a potential therapeutic strategy in human inflammatory bowel diseases.
Cutting Edge: NLRC5-Dependent Activation of the Inflammasome
Creators: name: Huang, Max T.
name: Ting, Jenny P.Y.
name: Willingham, Stephen B.
name: Duncan, Joseph A.
name: Conti, Brian J.
name: Taxman, Debra J.
name: Davis, Beckley K.
name: Barker, Brianne R.
name: Kwan, Mildred
name: Brickey, W. June
name: Roberts, Reid A.
name: Accavitti-Loper, Mary Ann
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The nucleotide-binding domain (NBD) leucine rich repeat (LRR) containing proteins, NLRs, are intracellular sensors of PAMPs and DAMPs. A subgroup of NLRs can form inflammasome complexes, which facilitate the maturation of pro-caspase-1 to caspase-1, leading to IL-1β and IL-18 cleavage and secretion. NLRC5 is predominantly expressed in hematopoetic cells and has not been studied for inflammasome function. RNAi-mediated knockdown of NLRC5 nearly eliminated caspase-1, IL-1β and IL-18 processing in response to bacterial infection, PAMPs and DAMPs. This was confirmed in primary human monocytic cells. NLRC5 together with procaspase-1, pro-IL-1β and the inflammasome adaptor, ASC, reconstituted inflammasome activity which showed cooperativity with NLPR3. The range of pathogens that activate NLRC5 inflammasome overlaps with those that activate NLRP3. Furthermore, NLRC5 biochemically associates with NLRP3 in an NBD-dependent but LRR-inhibitory fashion. These results invoke a model where NLRC5 interacts with NLRP3 to cooperatively activate the inflammasome.
Configuration Interaction with Antisymmetrized Geminal Powers
Creators: name: Uemura, Wataru
name: Kasamatsu, Shusuke
name: Sugino, Osamu
Publisher: name: arXiv
Year: 2015
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: To avoid the combinatorial computational cost of configuration interaction (CI), we have previously introduced the symmetric tensor decomposition CI (STD-CI) method, where we take advantage of the antisymmetric nature of the electronic wave function and express the CI coefficients compactly as a series of Kronecker product states (STD series) [W. Uemura and O. Sugino, Phys. Rev. Lett. 109, 253001 (2012)]. Here we extend the variational degrees of freedom by using different molecular orbitals for different terms in the STD series. This scheme is equivalent to the linear combination of the Hartree-Fock-Bogoliubov state or the antisymmetrized geminal powers (AGP). The total energy converges very rapidly within 0.72 $μ$Hartree taking only 10 terms for the water molecule, and the convergence is likewise fast for Hubbard tetramers. The computational cost scales as the fifth power of the number of electrons and the square of the number of terms in the STD series, indicating the promise of this AGP-based scheme for highly accurate and efficient computation of quantum systems.
description: 14 pages, 5 figures
Symbiotic polychaetes from Papua New Guinea associated with echinoderms, with descriptions of three new species
Creators: name: BRITAYEV, Temir A.
name: DOIGNON, Gilles
name: EECKHAUT, Igor
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1999

description: Six species of symbiotic polychaetes, three of them new to Science, were found in association with echinoderms
 collected in Papua New Guinea. More than 500 echinoderms were sampled, on (or in) which occurred ca.185 polychaetes.
 About 25% of the echinoderms were infested. The number of polychaetes per host infested was from one to four. Crinoids
 were the most infested, then ophiuroids, asteroids, and holothuroids. No polychaetes were observed on echinoids. The
 polynoid scaleworm Gastrolepidia clavigera, a well known symbiont with a wide Indo-Pacific distribution, was found on
 four species of holothurians. The polynoid Hololepidella millari sp. nov. infested species of two asteroids and one crinoid;
 the polynoids Paradyte crinoidicola and Hololepidella laingensis sp. nov. both occurred on 24 species of crinoids.
 Hololepidella nigropunctata and the phyllodocid Eumida ophiuricola sp. nov. were associated with two ophiuroid species.
 E. ophiuricola was found in the ophiuroid bursae while the five former species were ectosymbionts. E. ophiuricola is the
 second registered symbiotic species among the phyllodocids. The polychaetes are described and notes on their taxonomy and
 ecology are given, together with a list of the host species.
(1825) Frances Kean
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
SUR LES VARIATIONS DE LITTORINA SAXATILIS. VII. DES POPULATIONS CHANGENT ACTUELLEMENT D'ASPECT
Creators: name: FISCHER-PIETTE, E.
name: GAILLARD, J.-M.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1966

description: The authors, who for many years have regularly visited stations of Littorina saxatilis along the French and Iberian coasts, have noticed that the populations of many of these stations have, from one year to the other, acquired a darker colouring.  They suppose that an explanation would imply an indirect action on man’s part rather than some natural causes. Besides, they do not perceive in what it would consist, but think it may be interesting to briefly indicate the changes observed by them, so that others beside should be able to contribute their own attestation and investigate the causes.
title: The Market for Organic Oranges in Germany and the United States
Creators: name: Alexander, Jeremy
name: Engel, Connor
name: Hummel, Julia
name: Raffel, Fabienne
name: Stepanek, Hanna
name: Serikova, Tetiana
name: Williams, Jordan
Year: 2022
Subjects: subject: 300 Sozialwissenschaften

description: This market research paper has been prepared under the supervision of Prof. Dr. Agnieszka Gehringer of TH Köln and Prof. Dr. Carol Scovotti of University of Wisconsin-Whitewater in the course of the inter-university cross-border collaboration student research project “Export Opportunity Surveys (EOS)”. This study explores organic oranges export opportunities to the German and US markets.
description: EOS Series; 1/2022
Additional file 8 of Cross-protection against homo and heterologous influenza viruses via intranasal administration of an HA chimeric multiepitope nanoparticle vaccine
Creators: name: Zhao, Yongqiang
name: Liu, Jia
name: Peng, Chun
name: Guo, Shuangshuang
name: Wang, Bo
name: Chen, Longping
name: Wang, Yating
name: Tang, Haiwen
name: Liu, Liming
name: Pan, Qi
name: Li, Shiren
name: Wang, Jingyu
name: Yang, Dongni
name: Du, Enqi
Publisher: name: figshare
Year: 2025
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Supplementary Material 8: Additional file 8: table S2 Evaluation of the HA- and M2e-specific IgG endpoint titres in mice.
Insights into HLA-Restricted T Cell Responses in a Novel Mouse Model of Dengue Virus Infection Point toward New Implications for Vaccine Design
Creators: name: Peters, Bjoern
name: De Silva, Aruna D.
name: De Silva, Aravinda M.
name: Kolla, Ravi V.
name: Sette, Alessandro
name: Angelo, Michael A.
name: John, Daisy V.
name: Grey, Howard
name: Yauch, Lauren E.
name: Sidney, John
name: Weiskopf, Daniela
name: Shresta, Sujan
name: Greenbaum, Jason A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The frequency of dengue virus (DENV) infection has increased dramatically in the last few decades, and the lack of a vaccine has led to significant morbidity and mortality worldwide. To date, a convenient murine system to study human T cell responses to DENV has not been available. Mice transgenic for human leukocyte antigens (HLA) are widely used to model human immune responses and it has been shown that mouse-passaged DENV is able to replicate to significant levels in IFN-α/βR−/− mice. To cover a wide range of HLA phenotypes, we backcrossed IFN-α/βR−/− mice with HLA A*0201, A*0101, A*1101, B*0702 and DRB1*0101 transgenic mice. A DENV proteome-wide screen identified a total of 42 epitopes across all HLA-transgenic IFN-α/βR−/− strains tested. In contrast only 8 of these elicited responses in the corresponding IFN-α/βR+/+ mice. We were able to identify T cell epitopes from 9 out of the 10 DENV proteins. However, the majority of responses were derived from the highly conserved nonstructural proteins NS3 and NS5. The relevance of this model is further demonstrated by the fact that most of the epitopes identified in our murine system are also recognized by PBMC from DENV exposed human donors, and a dominance of HLA B*0702 restricted responses has been detected in both systems. Our results provide new insights into HLA-restricted T cell responses against DENV, and we herein describe a novel murine model, which allows the investigation of T cell-mediated immune mechanisms relevant to vaccine design.
title: Use of three-dimensional implicit geological modeling to assist groundwater management of a karst aquifer
Creators: name:  D'Affonseca , Fernando Mazo
name:  Cirpka , Olaf
name:  Finkel , Michael
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: Although 3-D geological modeling has been mostly employed in the prospection and exploitation of ores, oil and gas, its importance in the field of groundwater resources management is considerably increasing. Traditional 3-D geological modeling schemes are based on explicit digitization of geological units and structures. Progresses in 3-D interpolation techniques have favored the emergence of implicit modeling, in which geological surfaces are automatically created from hard data and interpretation. The major benefit of implicit modeling relies on its speed. In this work the implicit modeling approach was applied to conceptualize and model a karst aquifer in southwest Germany, using digital elevation data, geological maps, borehole logs, and geological interpretation. Dip and strike measurements as well as soil-gas surveys of mantel-borne CO2 were conducted to verify the existence of a postulated fault. The geological model was automatically translated into a numerical groundwater flow model that was calibrated to match measured hydraulic heads, spring discharge rates, and flow directions observed in tracer tests. Refinements of the numerical model’s spatial parametrization was iteratively conducted, using the geological model for visualization of interim simulations. As the results of numerical modeling may support or contradict the 3-D geological model, additional geological insights can be eventually gained in this way. The geological model allowed the proper assessment of the system geometry and the definition of boundary conditions. The numerical groundwater flow model was applied to evaluate the potential risks from limestone quarries to local water supply wells.
NFIL3 Is a Regulator of IL-12 p40 in Macrophages and Mucosal Immunity
Creators: name: Sheikh, Shehzad Z.
name: Hisamatsu, Tadakazu
name: Kamada, Nobuhiko
name: Pope, Scott D.
name: Rothman, Paul B.
name: Matsuoka, Katsuyoshi
name: Kobayashi, Taku
name: Hansen, Jonathan J.
name: Hibi, Toshifumi
name: Doty, Kevin R.
name: Kashiwada, Masaki
name: Plevy, Scott E.
name: Smale, Stephen T.
name: Elloumi, Houda Z.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Regulation of innate inflammatory responses against the enteric microbiota is essential for the maintenance of intestinal homeostasis. Key participants in innate defenses are macrophages. In these studies, the basic leucine zipper protein, NFIL3, is identified as a regulatory transcription factor in macrophages, controlling IL-12 p40 production induced by bacterial products and the enteric microbiota. Exposure to commensal bacteria and bacterial products induced NFIL3 in cultured macrophages and in vivo. The Il12b promoter has a putative DNA-binding element for NFIL3. Basal and LPS-activated NFIL3 binding to this site was confirmed by chromatin immunoprecipitation. LPS-induced Il12b promoter activity was inhibited by NFIL3 expression and augmented by NFIL3-short hairpin RNA in an Il12b-bacterial artificial chromosome-GFP reporter macrophage line. Il12b inhibition by NFIL3 does not require IL-10 expression, but a C-terminal minimal repression domain is necessary. Furthermore, colonic CD11b+ lamina propria mononuclear cells from Nfil3−/− mice spontaneously expressed Il12b mRNA. Importantly, lower expression of NFIL3 was observed in CD14+ lamina propria mononuclear cells from Crohn’s disease and ulcerative colitis patients compared with control subjects. Likewise, no induction of Nfil3 was observed in colons of colitis-prone Il10−/− mice transitioned from germ-free to a conventional microbiota. In conclusion, these experiments characterize NFIL3 as an Il12b transcriptional inhibitor. Interactions of macrophages with the enteric microbiota induce NFIL3 to limit their inflammatory capacity. Furthermore, altered intestinal NFIL3 expression may have implications for the pathogenesis of experimental and human inflammatory bowel diseases.
(1822) William Gordon
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
LEAP (Low Emissions Analysis Platform), como herramienta de prospectiva energética y ambiental y elaboración de NDCs
Creators: name: Di Sbroiavacca, Nicolás
name: Heaps, Charles
Publisher: name: Zenodo
Year: 2023
Subjects: LEAP

description: Taller Virtual en el uso del LEAP (Low Emissions Analysis Platform), como herramienta de prospectiva energética y ambiental y elaboración de NDCs.
Know the Star, Know the Planet. III. Discovery of Late-Type Companions to Two Exoplanet Host Stars
Creators: name: Roberts,, Lewis C.
name: Tokovinin, Andrei
name: Mason, Brian D.
name: Riddle, Reed L.
name: Hartkopf, William I.
name: Law, Nicholas M.
name: Baranec, Christoph
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We discuss two multiple star systems that host known exoplanets: HD 2638 and 30 Ari B. Adaptive optics imagery revealed an additional stellar companion to both stars. We collected multi-epoch images of the systems with Robo-AO and the PALM-3000 adaptive optics systems at Palomar Observatory and provide relative photometry and astrometry. The astrometry indicates that the companions share common proper motion with their respective primaries. Both of the new companions have projected separations less than 30 AU from the exoplanet host star. Using the projected separations to compute orbital periods of the new stellar companions, HD 2638 has a period of 130 yrs and 30 Ari B has a period of 80 years. Previous studies have shown that the true period is most likely within a factor of three of these estimated values. The additional component to the 30 Ari makes it the second confirmed quadruple system known to host an exoplanet. HD 2638 hosts a hot Jupiter and the discovery of a new companion strengthens the connection between hot Jupiters and binary stars. We place the systems on a color-magnitude diagram and derive masses for the companions which turn out to be roughly 0.5 solar mass stars.
description: Accepted to Astronomical Journal, 16 pages, 5 Figures
(1823) Michael Condon
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Diet of common torpedo Torpedo torpedo (Chondrichthyes: Torpedinidae) from the Lagoon of Bizerte (northeastern Tunisia, central Mediterranean)
Creators: name: EL KAMEL-MOUTALIBI, Olfa
name: MNASRI, Néjia
name: BOUMAÏZA, Moncef
name: REYNAUD, Christian
name: CAPAPÉ, Christian
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2013

description: Diet of common torpedo, Torpedo torpedo (Linnaeus, 1758) was studied in relation to sex, size and seasons from specimens collected in the Lagoon of Bizerte, a brackish area located in northeastern Tunisia (central Mediterranean). Of the 565 stomach contents examined between May 2010 and April 2011, 425 were empty, with vacuity index (VI) = 75.22%, percentage that significantly changed with sex. Only fourteen different taxa were recorded: 7 were osteichthyans, while crustaceans, annelids, cephalopods, and gasteropods were only represented each one by a single taxon. The dominant preys were osteichthyans, with %IRI = 41.74, among them gobiids were mainly found, as a consequence of feeding strategies observed in common torpedos. The trophic level (Troph) of 3.78 calculated for T. torpedo was high and pointed out that the species is a top carnivorous predator; additionally, no significant changes were recorded in Troph values related to sex, size and seasons.
Обоснование видов разрешенного использования земель сельскохозяйственного назначения
Creators: name: Волков Сергей
name: Вершинин Валентин
name: Черкашина Елена
name: Черкашин Кирилл
Publisher: name: Международный сельскохозяйственный журнал
Year: 2014
Subjects: ЗЕМЛИ СЕЛЬСКОХОЗЯЙСТВЕННОГО НАЗНАЧЕНИЯ
АGRICULTURAL LAND
СЕЛЬСКОХОЗЯЙСТВЕННЫЕ УГОДЬЯ
РАЦИОНАЛЬНОЕ ИСПОЛЬЗОВАНИЕ И ОХРАНА ЗЕМЕЛЬ
RATIONAL USE AND PROTECTION OF LAND
КАТЕГОРИИ И КЛАССЫ ЗЕМЕЛЬ
CATEGORIES AND CLASSES OF LAND
ЗЕРНОВОЙ ЭКВИВАЛЕНТ
GRAIN EQUIVALENT
ВИДЫ РАЗРЕШЕННОГО ИСПОЛЬЗОВАНИЯ
PERMITTED USE
AGRICULTURAL LAND ESTATES

description: Негативная ситуация с использованием и охраной земель сельскохозяйственного назначения требует ускоренного проведения мер по их защите в нормативном правовом, экономическом, социальном и экологическом отношениях. Установление видов разрешенного использования земель сельскохозяйственного назначения позволит сохранить земельно-ресурсный потенциал страны и обеспечить продовольственную безопасность Российской Федерации.Negative situation with the use and protection of agricultural land requires speeding up the measures for their protection in the normative legal, economic, social and environmental relations. Establishment of permitted uses of agricultural land will preserve the land and resource potential of the country and will ensure food security of the Russian Federation.
Phospholipase C- 3 Is a Key Modulator of IL-8 Expression in Cystic Fibrosis Bronchial Epithelial Cells
Creators: name: Crovella, Sergio
name: Rimessi, Alessandro
name: Pinton, Paolo
name: D'Adamo, Pio
name: Bisoffi, Giulia
name: Knowles, Michael R.
name: Bezzerri, Valentino
name: Lanzara, Carmen
name: Tamanini, Anna
name: Athanasakis, Emmanouil
name: Drumm, Mitchell L.
name: Tebon, Maela
name: Berton, Giorgio
name: Nicolis, Elena
name: Cabrini, Giulio
name: Gasparini, Paolo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Respiratory insufficiency is the major cause of morbidity and mortality in patients affected by cystic fibrosis. An excessive neutrophilic inflammation, mainly orchestrated by the release of IL-8 from bronchial epithelial cells and amplified by chronic bacterial infection with Pseudomonas aeruginosa, leads to progressive tissue destruction. The anti-inflammatory drugs presently utilized in cystic fibrosis patients have several limitations, indicating the need for identifying novel molecular targets. To address this issue, we preliminarily studied the association of 721 single-nucleotide polymorphisms from 135 genes potentially involved in signal transduction implicated in neutrophil recruitment in a cohort of F508del homozygous cystic fibrosis patients with either severe or mild progression of lung disease. The top ranking association was found for a nonsynonymous polymorphism of the phospholipase C beta 3 (PLCB3) gene. Studies in bronchial epithelial cells exposed to P.aeruginosa revealed that PLCB3 is implicated in extra cellular nucleotide–dependent intracellular calcium signaling, leading to activation of the protein kinase C alpha and beta and of the nuclear transcription factor NF-κB p65. The pro-inflammatory pathway regulated by PLCB3 acts by potentiating the Toll-like Receptors’ signaling cascade and represents an interesting molecular target to attenuate the excessive recruitment of neutrophils without completely abolishing the inflammatory response.
LA REPRODUCTION DES POISSONS PLATS (TELÉOSTÉENS - PLEURONECTIFORMES) EN BAIE DE DOUARNENEZ. I. - CYCLES SEXUELS ET FÉCONDITÉ DES ARNOGLOSSES ARNOGLOSSUS THORI, A. LATERNA, A. IMPERIALIS (BOTHIDAE)
Creators: name: DÉNIEL, Christian
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1983

Abstract
О разработке профессионального стандарта «Юрист по земельному праву»
Creators: name: Липски Станислав
name: Широкорад Ирина
Publisher: name: Международный сельскохозяйственный журнал
Year: 2016
Subjects: ПРОФЕССИОНАЛЬНЫЙ СТАНДАРТ
ЮРИСПРУДЕНЦИЯ
ЗЕМЕЛЬНЫЕ ОТНОШЕНИЯ
УРОВНИ ОБРАЗОВАНИЯ
PROFESSIONAL STANDARDS
LAW
LAND RELATIONS
LEVELS OF EDUCATION

description: В статье рассмотрены различные аспекты разработки профессионального стандарта «Юрист по земельному праву». Основное внимание уделено произошедшим изменениям в системе земельного законодательства и организации образовательного процесса, как факторам, обусловившим разработку такого стандарта.The article discusses various aspects examines the development of professional standard «Lawyer by land law». The focus is on occurred changes in the system of land legislation and the organization of educational process, as the factors behind the development of such a standard.
Repeated quantum error correction on a continuously encoded qubit by real-time feedback
Creators: name: Cramer, Julia
name: Kalb, Norbert
name: Rol, M. Adriaan
name: Hensen, Bas
name: Blok, Machiel S.
name: Markham, Matthew
name: Twitchen, Daniel J.
name: Hanson, Ronald
name: Taminiau, Tim H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Reliable quantum information processing in the face of errors is a major fundamental and technological challenge. Quantum error correction protects quantum states by encoding a logical quantum bit (qubit) in multiple physical qubits. To be compatible with universal fault-tolerant computations, it is essential that the states remain encoded at all times and that errors are actively corrected. Here we demonstrate such active error correction on a continuously protected qubit using a diamond quantum processor. We encode a logical qubit in three long-lived nuclear spins, repeatedly detect phase errors by non-destructive measurements using an ancilla electron spin, and apply corrections on the encoded state by real-time feedback. The actively error-corrected qubit is robust against errors and multiple rounds of error correction prevent errors from accumulating. Moreover, by correcting correlated phase errors naturally induced by the environment, we demonstrate that encoded quantum superposition states are preserved beyond the dephasing time of the best physical qubit used in the encoding. These results establish a powerful platform for the fundamental investigation of error correction under different types of noise and mark an important step towards fault-tolerant quantum information processing.
Effect of turbulent velocity on the \HI intensity fluctuation power spectrum from spiral galaxies
Creators: name: Dutta, Prasun
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We use numerical simulations to investigate effect of turbulent velocity on the power spectrum of \HI intensity from external galaxies when (a) all emission is considered, (b) emission with velocity range smaller than the turbulent velocity dispersion is considered. We found that for case (a) the intensity fluctuation depends directly only on the power spectrum of the column density, whereas for case (b) it depends only on the turbulent velocity fluctuation. We discuss the implications of this result in real observations of \HI fluctuations.
description: 13 pages, 4 figures, Submitted to MNRAS Letters
Практика проведения государственной кадастровой оценки земель населенных пунктов
Creators: name: Жданова Руслана
Publisher: name: Международный сельскохозяйственный журнал
Year: 2014
Subjects: ЗЕМЛИ НАСЕЛЕННЫХ ПУНКТОВ
LAND PLOT CADASTRE ASSESSMENT
ЗЕМЕЛЬНЫЙ УЧАСТОК
КАДАСТРОВАЯ ОЦЕНКА
АКТУАЛИЗАЦИЯ
ФАКТОРЫ СТОИМОСТИ
AND COST FACTORS
EARTH SETTLEMENTS
UPDATING

description: Рассмотрены проблемы при актуализации государственной кадастровой оценки земель населенных пунктов и причины их возникновения.The considered problem when updating cadastral valuation of lands of settlements and their causes.
Additional file 1 of Perspectives of substance use disorder counselors on the benefits and drawbacks of medications for opioid use disorder
Creators: name: Cardamone, Nicholas C.
name: Stewart, Rebecca E.
name: Kampman, Kyle M.
name: Marcus, Steven C.
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Supplementary Material 1
Рынок биопродуктов
Creators: name: Рубанов Иван
name: Фомин Александр
Publisher: name: Международный сельскохозяйственный журнал
Year: 2016
Subjects: БИОПРОДУКТЫ
БИОУДОБРЕНИЯ
БИОПЕСТИЦИДЫ
РЫНОК
СЕЛЬСКОЕ ХОЗЯЙСТВО
РАСТЕНИЕВОДСТВО
ЗЕМЛЕДЕЛИЕ
БИОТЕК
ОРГАНИЧЕСКИЙ
ПРОИЗВОДСТВО
ПРОДАЖИ
ТЕХНОЛОГИЯ
BIOLOGICALS
BIOFERTILISER
BIOPESTICIDE
AGRICULTURE
CROPPING
BIOTECH
ORGANIC
PRODUCTION
SALES
MARKET
TECHNOLOGY

description: Биопродукты товары, изготавливаемые на органической основе в заводских условиях для продажи и использования в сельском хозяйстве в дополнение или вместо синтетических химикатов. С 1990-х годов их выпуск и разработка превратилась в одно из быстрорастущих направлений биотехнологий. Стоимостной объем рынка превысил 3 млрд. долл. в год и увеличивается на 10-15% ежегодно. Биопродукты признаются лучшей с экологической точки зрения альтернативой и эффективным дополнением по отношению к искусственным химикатам удобрениям и пестицидам. Они особенно широко используются в растениеводстве, при фертигации, в декоративном садоводстве и в газонно-парковом хозяйстве, а в органическом сельском хозяйстве заменяют традиционные химические препараты. По функциональному назначению, составу и тоннажу биопродукты разделяют на четыре основных класса биоудобрения, биопестициды, биостимулянты и субстраты/кондиционеры. Ключевая группа производителей частные компании среднего размера. Старейший и наиболее крупный кластер таких компаний находится на севере Италии.Biologicals are goods, which manufactured from organics for consumption in agriculture instead or in addition to synthetic chemicals. Since 1990-s it has been rapidly growing segment of biotech industry. Worldwide sales of biologicals has exceed 3 billion dollars and growing 10-15% year-to-year. Biologicals considered as better alternative to chemicals fertilisers and pesticides. They used especially intensive in fertigation systems, on organic farms, for gardening and lawns. Biologicals subdivide in for classes according functionality, composition and tonnage, they are biofertilisers, biopesticides, biostimulants and substrates/soil conditioners. Key producers of biologicals are medium-sized private companies. The biggest cluster of them is situated in Northern Italy.
(1824) John Thomson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Plexin-D1 Is a Novel Regulator of Germinal Centers and Humoral Immune Responses
Creators: name: Jha, Sushmita
name: Zimmermann, Albert G.
name: Holl, Eda K.
name: Ting, Jenny P.Y.
name: O'Connor, Brian P.
name: Kelsoe, Garnett
name: Holl, T. Matt
name: Roney, Kelly E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Long-lived humoral immune responses depend upon the generation of memory B cells and long-lived plasma cells during the germinal center (GC) reaction. These memory compartments, characterized by class-switched IgG and high-affinity Abs, are the basis for successful vaccination. We report that a new member of the plexin family of molecules, plexin-D1, controls the GC reaction and is required for secondary humoral immune responses. Plexin-D1 was not required for B cell maturation, marginal zone precursor development, dark and light zone formation, Igλ+ and Igκ+ B cell skewing, B1/B2 development, and the initial extrafollicular response. Plexin-D1 expression was increased following B cell activation, and PlxnD1−/− mice exhibited defective GC reactions during T-dependent immune activation. PlxnD1−/− B cells showed a defect in migration toward the GC chemokines, CXCL12, CXCL13, and CCL19. Accordingly, PlxnD1−/− mice exhibited defective production of IgG1 and IgG2b, but not IgG3 serum Ab, accompanied by reductions in long-lived bone marrow plasmacytes and recall humoral memory responses. These data show a new role for immune plexins in the GC reaction and generation of immunologic memory.
A new species of Amphicorina (Polychaeta: Sabellidae:Sabellinae) from the Chafarinas Islands (Western Mediterranean)
Creators: name: LÓPEZ, Eduardo
name: TENA, José
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1999

description: A new species of Sabellinae (Sabellidae), Amphicorina triangulata, is described. This species is characterized by
 the shape of the collar (triangular and strongly reduced), by having four pair of radioles and one pair of ventral filaments in
 the branchial crown, six abdominal segments in adult specimens, and by the shape of ventral thoracic notochaetae and
 abdominal uncini. The material was collected from different substrata on rocky bottoms in the Chafarinas Islands (SW
 Mediterranean).
(1821) John MacGregor
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
К вопросу повышения эффективности и доступности полевых опрыскивателей Ростсельмаш на основе оценки информации об изменениях модельного ряда и локализации части производства на территории России
Creators: name: Фомин Александр
Publisher: name: Международный сельскохозяйственный журнал
Year: 2016
Subjects: CАМОХОДНЫЙ ОПРЫСКИВАТЕЛЬ
ПРИЦЕПНОЙ ОПРЫСКИВАТЕЛЬ

description: Рассматриваются вопросы рациональности изменения модельного ряда полевых самоходных и прицепных опрыскивателей РОСТСЕЛЬМАШ в плане их оптимизации в рамках отечественных условий, а также возможность локализации производства прицепных агрегатов в России в плане повышения их доступности для сельхозпроизводителей.Рассматриваются вопросы рациональности изменения модельного ряда полевых самоходных и прицепных опрыскивателей РОСТСЕЛЬМАШ в плане их оптимизации в рамках отечественных условий, а также возможность локализации производства прицепных агрегатов в России в плане повышения их доступности для сельхозпроизводителей.