cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Targeting Metabolism to Sensitise High-grade Gliomas to Current Standard Treatments
Creators: name: Cox, Thomas James Robert
Publisher: name: University of Surrey
Year: 2025
Subjects: Glioma
Radiosensitisation
NUDT5
IDH1
Glioblastoma
Metabolism
Nucleotide Metabolism
Radiotherapy

description: High-grade gliomas (HGG) are aggressive brain cancers treated with surgical resection
description: and the Stupp Protocol, comprising concurrent chemoradiotherapy and adjuvant
description: chemotherapy. However, since the Stupp Protocol, no significant therapeutic advances
description: have translated clinically, halting improvements in patient survival. Therefore, identifying
description: novel drug targets that enhance the Stupp Protocol’s therapeutic benefit is paramount.
description: A promising avenue is targeting somatic gain-of-function mutations in isocitrate
description: dehydrogenase (IDH) 1/2 genes. IDH-mutant HGG accumulate the oncometabolite D-2-
description: Hydroxyglutarate, depleting the essential metabolites; nicotinamide adenine dinucleotide
description: (NAD+) and nucleotides. This impairs metabolic pathways and DNA damage responses,
description: sensitising HGG to chemoradiotherapy and targeted therapies.
description: We investigated if targeting metabolic vulnerabilities within NAD+ and nucleotide
description: biosynthetic pathways could enhance chemoradiotherapy by screening a HGG panel,
description: including an isogenic IDH1-mutant, for sensitivity to metabolic inhibitors combined with
description: chemo- and radiotherapy. Identifying NUDT5, a Nudix hydrolase that catabolises
description: ADP-Ribose to replenish NAD+ pools, and synthesises nuclear ATP for chromatin remodelling,
description: as crucial for HGG survival.
description: Cell viability assays determined NUDT5 inhibition (NUDT5i) sensitised IDH1-wildtype
description: HGG to X-rays and α-particle radiotherapy modalities, whereas IDH1-mutant HGG were
description: sensitive to NUDT5i monotherapy. Subsequent live-cell imaging analysis indicated
description: NUDT5i induced cytostasis then cytotoxicity in IDH1-mutant HGG, suggesting IDH1-
description: mutations confer exploitable dependencies on NUDT5 for proliferation and survival.
description: NUDT5i did not significantly deplete NAD+ levels and NAD+ precursor supplementation
description: failed to rescue cell survival and proliferation, indicating NUDT5i effects are NAD+
description: independent. However, preliminary investigations into nucleoside supplementation
description: partially rescued NUDT5i effects on viability and preliminary γ-H2AX measurements
description: suggest NUDT5i induces DNA damage and impairs post-irradiation DNA repair in IDH1-
description: wildtype HGG, while IDH1-mutant HGG exhibit impaired damage recognition. Implying
description: NUDT5i may deplete nucleotide pools, inducing different radiosensitisation or
description: cytostasis/toxicity mechanisms dependent on IDH1 status.
description: This study identified NUDT5i as a promising HGG therapy, potentially enhancing Stupp
description: Protocol effectiveness regardless of IDH status and radiotherapy modality.
The D2 Susy Zoo
Creators: name: Bak, Dongsu
name: Ohta, Nobuyoshi
name: Townsend, Paul K.
Publisher: name: arXiv
Year: 2006
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We present new supersymmetric solutions of the Dirac-Born-Infeld equations for time-independent D2-branes, including a 1/2 supersymmetric `dyonic' D2-brane and various 1/4 supersymmetric configurations that include `twisted' supertubes, superfunnels with arbitrary planar cross-section, asymptotically planar D2-branes, and non-singular intersections of `magnetic' D2-branes. Our analysis is exhaustive for D2-branes in three space dimensions.
description: 28 pages, 1 figure; v2: minor corrections
Simulation of Returning Electrons from a Klystron Collector
Creators: name: Fang, Z.
name: Fukuda, S.
name: Yamaguchi, S.
name: Anami, S.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: Spurious oscillations in klystrons due to returning electrons from the collector into the drift tube were observed and studied at KEK. Simulations of returning electrons using EGS4 Monte Carlo method have been performed. And the oscillation conditions are described in this paper.
description: 3 pages, 6 figures, LINAC2000 conference
Case Study: Genetic Variation and Speciation in the Black Tailed Rattlesnake complex (Crotalus molossus)
Creators: name: Schlichte, Julie
name: Greenbaum, Eli
name: Zhuang, Vicky
Publisher: name: QUBES Educational Resources
Year: 2024

description: It is important for biology students to understand how genetic variation is related to the formation of species in nature. This module is intended for students to obtain first hand experience with a real world case study of how researchers working with a widely distributed species of snake detected that two different species were present. Through a video lecture featuring researchers, some of whom were involved in the black-tailed rattlesnake split, students explore the rationale for the taxonomic decisions outlined in the project. Subsequently, students are guided through a series of analytical processes working with the data from the 2012 study that are derived from genetic, morphological, and geographical information.
Una storia per colore: la riscrittura come modalità di apprendimento della struttura narrativa
Creators: name: Chioni, Melora
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2023
Subjects: struttura narrativa
riscrittura
albo illustrato
scrittura
testo narrativo

description: La ricerca di tesi è stata condotta in una pluriclasse di prima e seconda elementare composta da quattordici allievi e segue un approccio applicativo di tipo qualitativo. Il percorso proposto verte su una modalità di apprendimento delle sequenze del testo narrativo, ovvero la riscrittura, attraverso la quale i bambini possono interiorizzare e imparare a utilizzare nelle loro produzioni scritte tali sequenze in maniera sempre più efficace. Attraverso la proposta e l’analisi di alcuni testi narrativi e successivamente la riscrittura degli stessi gli alunni interiorizzano la struttura narrativa in modo da riuscire ad attingere alla stessa nel momento in cui sono chiamati a dover scrivere un testo narrativo. Il percorso è stato accompagnato in particolar modo dalla riscrittura dell’albo illustrato Un colore tutto mio di Leo Lionni e dalla creazione di un albo illustrato da parte degli allievi, che ha costituito un aspetto motivazionale. L’albo illustrato, infatti, rappresenta un ottimo punto di partenza per proporre attività legate alla scrittura in quanto risulta essere vicino al vissuto del bambino. Grazie all’analisi dei testi prodotti dai bambini si può osservare come la struttura del testo narrativo sia stata compresa e successivamente adottata nella scrittura di testi narrativi dalla maggior parte degli allievi. Relatore: Simone Fornara.
Fiber II, displaced abomasum as a herd problem
Creators: name: Olson, William G.
name: Stevens, J. B.
Publisher: name: The Bovine Practitioner
Year: 1984

description: Displaced abomasums (DA’s) can be a serious herd problem. Often DA’s may be preceded by other metabolic diseases at parturition such as milk fever or fatty liver syndrome. Various authors have described a variety of possible causes. Today we hear of DA’s occurring pre- or post-partum most often in the first 2 months of lactation. It is not uncommon for DA’s to occur at any time of the lactation cycle. As a part of the metabolic profile test design project and our field services program, a standard approach was used to study these herd problems.
description: The Bovine Practitioner, No. 19 (1984 November)
Investigating the interstellar dust through the Fe K-edge
Creators: name: Rogantini, D.
name: Costantini, E.
name: Zeegers, S. T.
name: de Vries, C. P.
name: Bras, W.
name: de Groot, F.
name: Mutschke, H.
name: Waters, L. B. F. M.
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The chemical and physical properties of interstellar dust in the densest regions of the Galaxy are still not well understood. X-rays provide a powerful probe since they can penetrate gas and dust over a wide range of column densities (up to $10^{24}\ \rm{cm}^{-2}$). The interaction (scattering and absorption) with the medium imprints spectral signatures that reflect the individual atoms which constitute the gas, molecule, or solid. In this work we investigate the ability of high resolution X-ray spectroscopy to probe the properties of cosmic grains containing iron. Although iron is heavily depleted into interstellar dust, the nature of the Fe-bearing grains is still largely uncertain. In our analysis we use iron K-edge synchrotron data of minerals likely present in the ISM dust taken at the European Synchrotron Radiation Facility. We explore the prospects of determining the chemical composition and the size of astrophysical dust in the Galactic centre and in molecular clouds with future X-ray missions. The energy resolution and the effective area of the present X-ray telescopes are not sufficient to detect and study the Fe K-edge, even for bright X-ray sources. From the analysis of the extinction cross sections of our dust models implemented in the spectral fitting program SPEX, the Fe K-edge is promising for investigating both the chemistry and the size distribution of the interstellar dust. We find that the chemical composition regulates the X-ray absorption fine structures in the post edge region, whereas the scattering feature in the pre-edge is sensitive to the mean grain size. Finally, we note that the Fe K-edge is insensitive to other dust properties, such as the porosity and the geometry of the dust.
description: 11 pages, 10 figures. Accepted for publication in Astronomy and Astrophysics
Milk fever prevention update and vitamin D3 toxicity
Creators: name: Olson, William G.
Publisher: name: The Bovine Practitioner
Year: 1984

description: Discussing problems of milk fever with practicing veterinarians today reveals that in some herds there are occasionally epidemics that occur for a variable period of time in some herds. The overall incidence in the U.S. is apparently down from the 8-9% of the 1960’s to about 6-7%. However, sales of milk fever treatments may be rather stable. This may also mean that the average milk fever cow may get 2 bottles per treatment. Today, in the large herds, where caloric and calcium intake are very closely regulated to minimize overfeeding of energy and calcium, the herd incidence of milk fever may be below 1%. The major question for the medium size farm is whether or not it is worthwhile to prevent milk fever if the management upset is too great. This is a real problem for dairymen on all legume forages.
description: The Bovine Practitioner, No. 19 (1984 November)
Additional file 3 of Characterization of distinct circular RNA signatures in solid tumors
Creators: name: Wang, Chengdi
name: Liu, Wen-Rong
name: Tan, Shuangyan
name: Zhou, Jian-Kang
name: Xu, Xiaomin
name: Ming, Yue
name: Cheng, Jian
name: Li, Jiao
name: Zeng, Zhen
name: Zuo, Yuanli
name: He, Juan
name: Peng, Yong
name: Li, Weimin
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 3: Table S3. Information of primers and probes used in this study. Table S4. The distribution of putative spliced length of exonic circRNAs. Table S5. Exon numbers of identified exonic circRNAs. Table S6. The circRNAs expressed higher than its host genes. Table S7. The number of circRNAs produced from one gene. Table S12. Information of tissue-specific RBPs.
The Effect of Gas Loss on the Formation of Bound Stellar Clusters
Creators: name: Geyer, Michael P.
name: Burkert, Andreas
Publisher: name: arXiv
Year: 2000
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The effect of gas ejection on the structure and binding energy of newly formed stellar clusters is investigated. The star formation efficiency (SFE), necessary for forming a gravitationally bound stellar cluster, is determined. Two sets of numerical N-body simulations are presented: As a first simplified approach we treat the residual gas as an external potential. The gas expulsion is approximated by reducing the gas mass to zero on a given timescale, which is treated as a free parameter. In a second set of simulations we use smoothed particle hydrodynamics (SPH) to follow the dynamics of the outflowing residual gas self-consistently. We investigate cases where gas outflow is induced by an outwards propagating shock front and where the whole gas cloud is heated homogeneously, leading to ejection. If the stars are in virial equilibrium with the gaseous environment initially, bound clusters only form in regions where the local SFE is larger than 50% or where the gas expulsion timescale is long compared to the dynamical timescale. A small initial velocity dispersion of the stars leads to a compaction of the cluster during the expulsion phase and reduces the SFE needed to form bound clusters to less than 10%.
description: 6 pages, 7 figures, submitted to MNRAS
Long-term scheduling of a single-stage multi-product continuous process to manufacture high performance glass
Creators: name: Lima, Ricardo M.
name: Grossmann, Ignacio E.
name: Jiao, Yu
Publisher: name: Carnegie Mellon University
Year: 2009
Subjects: subject: 90499 Chemical Engineering not elsewhere classified
subject: FOS: Chemical engineering

description: In this paper the long-term scheduling of a real world multi-product single stage continuous process for manufacturing glass is studied. This process features long minimum run lengths, and sequence dependent changeovers of the order of days, with high transition costs. The long-term scheduling involves extended time horizons that lead to large scale mixed integer linear programming (MILP) scheduling models. In order to address the difficulties posed by the size of the models, three different rolling horizon algorithms based on different models and time aggregation techniques are studied. The models used are based on the continuous time slot MILP model, and on the traveling salesman model proposed by Erdirik-Dogan and Grossmann (2008). Due to the particular characteristics of the process under study, several new features are proposed, which include: a) carry-over changeovers across the due dates; b) minimum run lengths across the due dates; c) a rigorous aggregation of the products based on the type of changeovers; d) definition of minimum inventory levels at the end of the time horizon. Several case studies are formulated in order to compare different scenarios, and assess the proposed rolling horizon algorithms.
Femtoscopy via Levy sources with PHENIX at RHIC
Creators: name: Csanad, Mate
Publisher: name: arXiv
Year: 2017
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Charged pion two-particle correlation functions were measured in 0-30% centrality 200 GeV Au+Au collisions with the PHENIX experiment at RHIC. The measured correlation functions can be statistically well described based on the assumption of Levy-shaped source distributions. In this proceedings paper we present the Levy parameters of the measured correlation functions: correlation strength parameter lambda, Levy index alpha and Levy scale parameter R as a function of pair transverse mass mT, in 31 bins from 228 to 871 MeV, separately for positive and negative pion pairs. We discuss the physical interpretation of the mT dependence of the parameters.
description: Write-up of a poster presented at the XXXVII International Symposium on Physics in Collision
Salt deficiency, iodine toxicity and when you say "It must be the feed" you may have to say it in court
Creators: name: Olson, William G.
Publisher: name: The Bovine Practitioner
Year: 1984

description: We have encountered several herd complaints which have had salt deficiency as the primary cause of production decline or loss.
description: The Bovine Practitioner, No. 19 (1984 November)
Déclaration européenne des droits de l'animal
Creators: name: A group of French jurists identified in the document
Publisher: name: Zenodo
Year: 2025
Subjects: subject: Animal Rights
subject: Animal Rights/history
subject: Animal Rights/trends

description: The Déclaration européenne des droits de l’animal (DEDA, European Declaration of Animal Rights). This document was published in January 2025 by a group of French jurists and endorsed by a considerable number of European animal advocacy associations and foundations. The GISI reproduces it here in the original French redaction in connection to a Call for Papers for a Special Issue of the Journal of Interdisciplinary History of Ideas.

The authors of the Déclaration are listed in the document.
A proof of Jarzynski's non-equilibrium work theorem for dynamical systems that conserve the canonical distribution
Creators: name: Scholl-Paschinger, Elisabeth
name: Dellago, Christoph
Publisher: name: arXiv
Year: 2006
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We present a derivation of the Jarzynski identity and the Crooks fluctuation theorem for systems governed by deterministic dynamics that conserves the canonical distribution such as Hamiltonian dynamics, Nose-Hoover dynamics, Nose-Hoover chains and Gaussian isokinetic dynamics. The proof is based on a relation between the heat absorbed by the system during the non-equilibrium process and the Jacobian of the phase flow generated by the dynamics.
description: 12 pages
LOGMIP : a discrete continuous nonlinear optimizer
Creators: name: Vecchietti, Aldo
name: Grossmann, Ignacio E.
Publisher: name: Carnegie Mellon University
Year: 1996
Subjects: subject: 90499 Chemical Engineering not elsewhere classified
subject: FOS: Chemical engineering

description: Abstract: "Discrete-continuous non-linear optimization models are frequently used to formulate problems in Process System Engineering. Major modeling alternatives and solution algorithms include generalized disjunctive programming and MINLP. Both have advantages and drawbacks depending on the problem they are dealing with. In this work, we describe the theory behind LOGMIP, a new computer code for disjunctive programming and MINLP. We discuss a hybrid modeling framework which combines both approaches, allowing binary variables and disjunctions for expressing discrete choices. An extension of the Logic-Based OA algorithm has been implemented to solve the proposed hybrid model. Computational experience is reported on several examples, which are solved within disjunctive, MINLP and hybrid approaches."
Simulation of an Intra-Pulse Interaction Point Feedback for Future Linear Colliders
Creators: name: Schulte, D.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: In future normal-conducting linear colliders, the beams will be delivered in short bursts with a length of the order of 100 ns. The pulses will be separated by several ms. In order to maintain high luminosity, feedback is necessary on a pulse-to-pulse basis. In addition, intra-pulse feedback that can correct beam positions and angles within one pulse seem technically feasible. The likely performances of different feedback options are simulated for the NLC (Next Linear Collider) and CLIC (Compact Linear Collider).
description: LINAC2000 Conference, Paper ID MOA02
Retrieving the Aerosol Complex Refractive Index using PyMieScatt: A Mie Computational Package with Visualization Capabilities
Creators: name: Sumlin, Benjamin J.
name: Heinson, William R.
name: Chakrabarty, Rajan K.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences
subject: 78-04

description: The complex refractive index m=n+ik of a particle is an intrinsic property which cannot be directly measured, it must be inferred from its extrinsic properties such as the scattering and absorption cross-sections. Bohren and Huffman called this approach describing the dragon from its tracks, since the inversion of Lorenz-Mie theory equations is intractable without the use of computers. This article describes PyMieScatt, an open-source module for Python that contains functionality for solving the inverse problem for complex m using extensive optical and physical properties as input, and calculating regions where valid solutions may exist within the error bounds of laboratory measurements. Additionally, the module has comprehensive capabilities for studying homogeneous and coated single spheres, as well as ensembles of homogeneous spheres with user-defined size distributions, making it a complete tool for studying the optical behavior of spherical particles.
description: Includes main text and supplementary material, Journal of Quantitative Spectroscopy and Radiative Transfer, 2017
A REVIEW ARTICLE ON OVER-THE-COUNTER DRUGS
Creators: name: C.Venkatesh, Dr.M.sphurthy Mitra,
Publisher: name: Zenodo
Year: 2024

description: Over-the-counter (OTC) drug is a medicine that is available without a prescription, and hence also referred to as “non-prescription drug.” The sale of OTC medicines from pharmacies can help individual’s self-manage symptoms. However, some OTC medicines may be abused, with addiction and harms being increasingly recognized and found to be more common in more people.

Shall mostly refer to medicines that are only available in pharmacies, rather than those on the General Sales List, which are available through supermarkets and other outlets without the supervision of a pharmacist. I shall also assume that pharmacists are alive to the problems of self-medication by patients and will take steps to advise them about seeking medical advice when appropriate. This is not true in all countries, and I shall therefore mostly restrict my comments to the UK, where it is. Self-care and self-medication are common practices in any health care system.

Abuse is characterized as over-consumption beyond the approved medical practice or medical norms when the hazards and unfavourable consequences outweigh the advantages. These include self-medicating at higher quantities and for longer periods of time than recommended. Improved knowledge, understanding about self-medication result in rationale self-medication procedure includes the usage of Over-the-counter or non-prescription drugs which are obtained by individuals without a prescription from a physician for the treatment of common ailments. Lower costs, convenience, availability, and the ability to control one’s own illness are the potential benefits of over-the-counter- drugs. The risk of drug misuse, dependence, and adverse drug events is increased when the drugs are used inappropriately. Misuse and use. There is an urgent need to implement legislation to promote judicious and rational use of over-the-counter drugs The sale of over-the-counter (OTC) medicines from pharmacies can help individuals self-manage symptoms.

OTC medicine abuse was identified in many countries and although implicated products varied, five key groups emerged: codeine-based (especially compound analgesic) medicines, cough products (particularly dextromethorphan), sedative antihistamines, decongestants and laxatives.. Associated harms included direct physiological or psychological harm (e.g. opiate addiction), harm from another ingredient (e.g. ibuprofen-related gastric bleeding) and associated social and economic problems. Strategies and interventions included limiting supplies, raising public and professional awareness and using existing services and Internet The public generally believes OTC medicines to be helpful for treating minor ailments.
การวางแผนกลยุทธ์เพื่อพัฒนาการท่องเที่ยวบนรากฐานเศรษฐกิจชีวภาพ ฝ่าวิกฤตการระบาดของโรคติดเชื้อไวรัสโคโรนา 2019 (COVID-19)
Creators: name: นงคราญ ไชยเมือง
name: สุตาภัทร คงเกิด
name: จงรักษ์ ศรีคำหน้อย
Publisher: name: วารสารมหาวิทยาลัยพายัพ
Year: 2021
Subjects: การพัฒนาการท่องเที่ยวบนรากฐานเศรษฐกิจชีวภาพ
การวางแผนกลยุทธ์
วิกฤตการระบาดของโรคติดเชื้อไวรัสโคโรนา 2019 (COVID-19)

description: วารสารมหาวิทยาลัยพายัพ, 31, 1, 134
Spacetimes with Longitudinal and Angular Magnetic Fields in Third Order Lovelock Gravity
Creators: name: Dehghani, M. H.
name: Bostani, N.
Publisher: name: arXiv
Year: 2006
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We obtain two new classes of magnetic brane solutions in third order Lovelock gravity. The first class of solutions yields an $(n+1)$-dimensional spacetime with a longitudinal magnetic field generated by a static source. We generalize this class of solutions to the case of spinning magnetic branes with one or more rotation parameters. These solutions have no curvature singularity and no horizons, but have a conic geometry. For the spinning brane, when one or more rotation parameters are nonzero, the brane has a net electric charge which is proportional to the magnitude of the rotation parameters, while the static brane has no net electric charge. The second class of solutions yields a pacetime with an angular magnetic field. These solutions have no curvature singularity, no horizon, and no conical singularity. Although the second class of solutions may be made electrically charged by a boost transformation, the transformed solutions do not present new spacetimes. Finally, we use the counterterm method in third order Lovelock gravity and compute the conserved quantities of these spacetimes.
description: 15 pages, no figure
Supervised and Unsupervised Speech Enhancement Using Nonnegative Matrix Factorization
Creators: name: Mohammadiha, Nasser
name: Smaragdis, Paris
name: Leijon, Arne
Publisher: name: arXiv
Year: 2017
Subjects: subject: Sound (cs.SD)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Reducing the interference noise in a monaural noisy speech signal has been a challenging task for many years. Compared to traditional unsupervised speech enhancement methods, e.g., Wiener filtering, supervised approaches, such as algorithms based on hidden Markov models (HMM), lead to higher-quality enhanced speech signals. However, the main practical difficulty of these approaches is that for each noise type a model is required to be trained a priori. In this paper, we investigate a new class of supervised speech denoising algorithms using nonnegative matrix factorization (NMF). We propose a novel speech enhancement method that is based on a Bayesian formulation of NMF (BNMF). To circumvent the mismatch problem between the training and testing stages, we propose two solutions. First, we use an HMM in combination with BNMF (BNMF-HMM) to derive a minimum mean square error (MMSE) estimator for the speech signal with no information about the underlying noise type. Second, we suggest a scheme to learn the required noise BNMF model online, which is then used to develop an unsupervised speech enhancement system. Extensive experiments are carried out to investigate the performance of the proposed methods under different conditions. Moreover, we compare the performance of the developed algorithms with state-of-the-art speech enhancement schemes using various objective measures. Our simulations show that the proposed BNMF-based methods outperform the competing algorithms substantially.
Chemical profiling of DNA G-quadruplex-interacting proteins in live cells.
Creators: name: Zhang, Xiaoyun
name: Spiegel, Jochen
name: Martínez Cuesta, Sergio
name: Adhikari, Santosh
name: Balasubramanian, Shankar
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021

description: DNA-protein interactions regulate critical biological processes. Identifying proteins that bind to specific, functional genomic loci is essential to understand the underlying regulatory mechanisms on a molecular level. Here we describe a co-binding-mediated protein profiling (CMPP) strategy to investigate the interactome of DNA G-quadruplexes (G4s) in native chromatin. CMPP involves cell-permeable, functionalized G4-ligand probes that bind endogenous G4s and subsequently crosslink to co-binding G4-interacting proteins in situ. We first showed the robustness of CMPP by proximity labelling of a G4 binding protein in vitro. Employing this approach in live cells, we then identified hundreds of putative G4-interacting proteins from various functional classes. Next, we confirmed a high G4-binding affinity and selectivity for several newly discovered G4 interactors in vitro, and we validated direct G4 interactions for a functionally important candidate in cellular chromatin using an independent approach. Our studies provide a chemical strategy to map protein interactions of specific nucleic acid features in living cells.
Defect modes of a Bose-Einstein condensate in an optical lattice with a localized impurity
Creators: name: Brazhnyi, V. A.
name: Konotop, V. V.
name: Pérez-García, V. M.
Publisher: name: arXiv
Year: 2006
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Pattern Formation and Solitons (nlin.PS)
subject: FOS: Physical sciences

description: We study defect modes of a Bose-Einstein condensate in an optical lattice with a localized defect within the framework of the one-dimensional Gross-Pitaevskii equation. It is shown that for a significant range of parameters the defect modes can be accurately described by an expansion over Wannier functions, whose envelope is governed by the coupled nonlinear Schrödinger equation with a delta-impurity. The stability of the defect modes is verified by direct numerical simulations of the underlying Gross-Pitaevskii equation with a periodic plus defect potentials. We also discuss possibilities of driving defect modes through the lattice and suggest ideas for their experimental generation.
description: 14 pages, 9 Figures, 1 Table
Problem solving session II
Creators: name: Miller, Rick
name: Doig, Paul
name: Hanson, Lyle
name: Ball, Les
name: Manspeaker, Joe
Publisher: name: The Bovine Practitioner
Year: 1984

description: Transcription of a meeting between the authors to discuss reproductive management and answer various questions.
description: The Bovine Practitioner, No. 19 (1984 November)
Decentralized stabilization of large-scale linear parameter varying systems
Creators: name: Dehghani, Maryam
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 400705
subject: Control engineering

description: In stabilization of a Large-Scale System (LSS), the decentralized nature of the controller is a significant issue, because centralized controllers are difficult and impractical for real-time implementation. The designing procedure for decentralized controllers should guarantee the stability of the overall LSS and at the same time, allow limited information exchange in the LSS. In this paper, a decentralized controller for a nonlinear LSS modeled by a Linear Parameter Varying (LPV) model is designed. The controller design procedure is formulated as a convex feasibility problem which can be solved by finding a feasible answer to some Linear Matrix Inequalities (LMIs). The solution to this feasibility problem assures a fully decentralized controller where information exchange among local controllers is forbidden and only the transfer of data among each controller and its corresponding subsystem is allowed. In the proposed approach, the Lyapunov function of the LSS equipped with local controllers is considered as the summation of the Lyapunov functions of all subsystems. Then, the stability conditions are derived to assure the stability of the LSS. After designing a decentralized controller to assure LSS stability, the same approach is exploited for Hinf and H2 performance improvement of the LSS in presence of disturbances. To verify the efficacy of the designed controller, large-scale power system is considered as a practical examples and the proposed approach is applied on it. The simulation results prove the appropriateness of the designed local controllers.The results of this research is published in the following paper:Dehghani, M., 2024. Decentralized stabilization of large-scale linear parameter varying systems. ISA Transactions.The source codes of the paper simulations are available in the attachment. Please refer to the above paper when you use the attached files.
title: New anti HIV Drug Dolutegravir is Effective at Low Doses and in the Search for a HIV Cure
Creators: name: Leibowitch, Jacques
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Lafeuillade, Alain (1961-...)

description: Article sur les recherches d'Alain Lafeuillade, extrait du site http://www.mmdnewswire.com ; suivi de la traduction française sur un fichier texte.
description: Source: http://www.calames.abes.fr/pub/ms/Calames-201931112328303134
description: Relation: http://www.mmdnewswire.com
description: created: start=1975;end=2018
The Disinhibited Brain: Combinatorial Coding & Disinhibition at Axon Hillocks for Human Intelligence and Memory Formation
Creators: name: Thomas, Abraham
Publisher: name: Zenodo
Year: 2024

description: The human brain's incredible memory and pattern recognition capabilities remain a mystery. This paper explores an algorithmic mechanism, the Axon Disinhibition Mechanism (ADM), to explain how billions of neurons achieve these feats. ADM proposes that combinatorial responses to dendritic inputs occur at the axon hillock, where disinhibition triggers action potentials. This model suggests a simple binary logic governing complex behavior, ignoring subthreshold potentials and focusing on the "on/off" states of axon hillocks. Unlike other models, ADM offers potentially scalable information storage and retrieval through its combinatorial coding capacity. The paper starts with a hypothetical "zero active state" where GABA inhibits all axon hillocks and progresses to an active state representing complex emotions. While acknowledging the limitations of simplifying a complex system, ADM aims to bridge disciplines and contribute to understanding the brain's computational core. Compared to existing theories like LTP, ADM specifically addresses the ability to remember and recall vast amounts of information. While the terminology reflects the author's engineering background, the core findings transcend disciplines, seeking to spark further discussion on the interplay between technology and biological systems.
Large-scale decomposition for successive quadratic programming
Creators: name: S  Vasantharajan
name: Biegler, Lorenz T.
name: Carnegie Mellon University.Engineering Design Research Center.
Publisher: name: Carnegie Mellon University
Year: 1987
Subjects: subject: 90499 Chemical Engineering not elsewhere classified
subject: FOS: Chemical engineering

description: Successive Quadratic Programming (SQP) has emerged as the algorithm of choice for solving moderately-sized nonlinear process optimization problems. However, as the nonlinear programming problem becomes large (over 100 varialbes, say) storage requirements for the Hessian Matrix and the computational expense of solving large quadratic programs can become prohibitive. To overcome this problem, Westerberg and coworkers proposed two SQP decomposition strategies in 1980 and 1983. The first strategy overcomes this problems but is difficult to implement, while the second has been observed to give inconsistent results.The strategy in this papaer used range and null space projections to develop a decompositiion algorithm that is both easy to implement and performs as well as the full SQP algorithm on small problems. This range and null space decomposition (RND) allows for sparse implementations and thus solves large problems easily and reliabley. Theoretical development of the RND method is presented as well as a geometric interpretation of this approach compared to others. Finally, a thorough numerical comparison of SQP strategies is presented on a battery of nonlinear programming and process optimization test problems.
Towards Reliable Acceleration of High-energy and High-intensity Electron Beams
Creators: name: Furukawa, K.
name: Group, Linac Commissioning
Publisher: name: arXiv
Year: 2000
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: KEK electron linac was upgraded to 8 GeV for the KEK B-Factory (KEKB) project. During the commissioning of the upgraded linac, even continuing SOR ring injections, we had achieved a primary electron beam with 10-nC (6.24 x 10^10) per bunch up to 3.7-GeV for positron generation. This could be classified as one of the brightest S-band linac's. Since the KEKB rings were completed in December 1998, those 3.5-GeV position and 8-GeV electron beams have been injected with an excellent performance. Moreover, we have succeeded in switching among the high-intensity beams for KEKB and beams for two SOR rings with sufficient reproducibility. After the commissioning of the KEKB ring started, we have launched a project to stabilize the intensity and quality of the high-current beams furthermore, and have accomplished it investigating every conceivable aspect.
description: 3pages, LaTeX, LINAC2000, TUE09, english correction
Fiber I - milk fat depression
Creators: name: Olson, William G.
Publisher: name: The Bovine Practitioner
Year: 1984

description: Milk fat depression is a sporadic problem usually encountered when the crude fiber in the total ration declines below 17% on a dry matter basis. The following discussion of fiber and its analysis is presented as a basis for several succeeding papers here today.
description: The Bovine Practitioner, No. 19 (1984 November)
Gravitating multidefects from higher dimensions
Creators: name: Giovannini, Massimo
Publisher: name: arXiv
Year: 2006
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Warped configurations admitting pairs of gravitating defects are analyzed. After devising a general method for the construction of multidefects, specific examples are presented in the case of higher-dimensional Einstein-Hilbert gravity. The obtained profiles describe diverse physical situations such as (topological) kink-antikink systems, pairs of non-topological solitons and bound configurations of a kink and of a non-topological soliton. In all the mentioned cases the geometry is always well behaved (all relevant curvature invariants are regular) and tends to five-dimensional anti-de Sitter space-time for large asymptotic values of the bulk coordinate. Particular classes of solutions can be generalized to the framework where the gravity part of the action includes, as a correction, the Euler-Gauss-Bonnet combination. After scrutinizing the structure of the zero modes, the obtained results are compared with conventional gravitating configurations containing a single topological defect.
description: 27 pages, 5 included figures
title: ADCO, Grènetier de Cîteaux : comptes (1497-1504) (11 H 1172), f. 00454
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: comptes
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172), f. 00454, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
title: Fare musica nel primo ciclo
title: Un percorso di educazione musicale integrata, tra narrazione e creatività
titleType: AlternativeTitle
Creators: name: Galassetti, Anna
name: Piricò, Matteo Luigi
Publisher: name: SUPSI, Dipartimento formazione e apprendimento / Alta scuola pedagogica
Year: 2024

description: Il quaderno didattico "Fare musica nel primo ciclo. Un percorso di educazione musicale integrata, tra narrazione e creatività", mira a proporre un approccio dinamico all'educazione musicale attraverso un concetto di “educazione musicale integrata”, enfatizzando la forza propulsiva della narrazione, lo sviluppo creativo e la compenetrazione tra più codici espressivi. Con un focus particolare sul primo ciclo scolastico, propone un percorso che arricchisce l'apprendimento attraverso la musica, guidato dalle idee creative di Anna Galassetti, che presenta un file rouge narrativo che collega le diverse canzoni, e sostenuto dalla teoria dell'embodied cognition, che coniuga corpo e apprendimento. Le attività, variamente adattabili, mirano a una costruzione condivisa di esperienze significative, promuovendo l'interazione sociale e la collaborazione, essenziali nell'educazione musicale. Il contributo di Jessica Gallarate nella grafica e di Marina Pettignano nella creazione dei testi sottolinea l'importanza di un approccio multidisciplinare, che integra arte, musica e poesia. La raccolta, arricchita anche da brani di docenti del territorio, mostra il valore della collaborazione educativa per creare materiali didattici innovativi, stimolando un insegnamento musicale flessibile e coinvolgente.
Negative magnetocaloric effect from highly sensitive metamagnetism in CoMnSi_{1-x}Ge_{x}
Creators: name: Sandeman, K. G.
name: Daou, R.
name: Ozcan, S.
name: Durrell, J. H.
name: Mathur, N. D.
name: Fray, D. J.
Publisher: name: arXiv
Year: 2006
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We report a novel negative magnetocaloric effect in CoMnSi_{1-x}Ge_{x} arising from a metamagnetic magnetoelastic transition. The effect is of relevance to magnetic refrigeration over a wide range of temperature, including room temperature. In addition we report a very high shift in the metamagnetic transition temperature with applied magnetic field. This is driven by competition between antiferromagnetic and ferromagnetic order which can be readily tuned by applied pressure and compositional changes.
description: 5 pages, 5 figures, REVTeX, submitted to Physical Review
An improvement of D-MORPH method for finding quantum optimal control
Creators: name: Zhdanov, Konstantin
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The paper examines the prominent algorithm D-MORPH to search for the optimal control of a quantum system in order to implement desired unitary evolution of the quantum system at the final time, and reveals new mathematical expressions for various orders' corrections to the algorithm, that include information about the commutators of the system's Hamiltonian. Inclusion of such corrections results in faster optimal quantum control's search with high precision, i.e. allows saving of computational resources.
description: This is an English translation of the article originally published in Russian
A Low Charge Demonstration of Electron Pulse Compression for the CLIC RF Power Source
Creators: name: Corsini, R.
name: Ferrari, A.
name: Potier, J. P.
name: Rinolfi, L.
name: Risselada, T.
name: Royer, P.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: The CLIC (Compact Linear Collider) RF power source is based on a new scheme of electron pulse compression and bunch frequency multiplication using injection by transverse RF deflectors into an isochronous ring. In this paper, we describe the modifications needed in the present LEP Pre-Injector (LPI) complex at CERN in order to perform a low-charge test of the scheme. The design of the injector (including the new thermionic gun), of the modified linac, of the matched injection line, and of the isochronous ring lattice, are presented. The results of preliminary isochronicity measurements made on the present installation are also discussed.
description: 3 pages, 5 figures, submitted to the LINAC 2000 Conference
A relativistic quantum theory of dyons wave propagation
Creators: name: Chanyal, B. C.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Beginning with the quaternionic generalization of the quantum wave equation, we construct a simple model of relativistic quantum electrodynamics for massive dyons. A new quaternionic form of unified relativistic wave equation consisting of vector and scalar functions is obtained, and also satisfy the quaternionic momentum eigenvalue equation. Keeping in mind the importance of quantum field theory, we investigate the relativistic quantum structure of electromagnetic wave propagation of dyons. The present quantum theory of electromagnetism leads to generalized Lorentz gauge conditions for the electric and magnetic charge of dyons. We also demonstrate the universal quantum wave equations for two four-potentials as well as two four-currents of dyons. The generalized continuity equations for massive dyons in case of quantum fields are expressed. Furthermore, we concluded that the quantum generalization of electromagnetic field equations of dyons can be related to analogous London field equations (i.e., current to electromagnetic fields in and around a superconductor).
description: 8 pages. arXiv admin note: text overlap with arXiv:hep-th/0608164 by other authors
Ground state cooling of atoms in optical lattices
Creators: name: Popp, M.
name: Garcia-Ripoll, J. J.
name: Vollbrecht, K. G. H.
name: Cirac, J. I.
Publisher: name: arXiv
Year: 2006
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We propose two schemes for cooling bosonic and fermionic atoms that are trapped in a deep optical lattice. The first scheme is a quantum algorithm based on particle number filtering and state dependent lattice shifts. The second protocol alternates filtering with a redistribution of particles by means of quantum tunnelling. We provide a complete theoretical analysis of both schemes and characterize the cooling efficiency in terms of the entropy. Our schemes do not require addressing of single lattice sites and use a novel method, which is based on coherent laser control, to perform very fast filtering.
description: 12 pages, 7 figures