cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Synaptojanin Forms Two Separate Complexes in the Nerve Terminal: INTERACTIONS WITH ENDOPHILIN AND AMPHIPHYSIN
Creators: name: Micheva, Kristina D.
name: Kay, Brian K.
name: McPherson, Peter S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: Endophilin is a recently discovered src homology 3 domain-containing protein that is a major in vitro binding partner for synaptojanin. To further characterize endophilin, we generated an antipeptide antibody. Endophilin is enriched in the brain, and immunofluorescence analysis reveals a high concentration of the protein in synaptic terminals, where it colocalizes with synaptojanin. In vitro binding assays demonstrate that endophilin binds through its src homology 3 domain to synaptojanin, and immunoprecipitation analysis with the antiendophilin antibody reveals that endophilin is stably associated with synaptojanin in the nerve terminal. Immunoprecipitation with an antibody against amphiphysin I and II, which interact through their src homology 3 domains with dynamin and synaptojanin at sites distinct from those for endophilin, reveals a second stable complex, which includes dynamin and synaptojanin but excludes endophilin. These data demonstrate that synaptojanin is present in two separate complexes in the nerve terminal and support an important role for endophilin in the regulation of synaptojanin function.
Information needs of young adults with cancer in Germany
Creators: name: Bressel, Paulina
Publisher: name: Humboldt-Universität zu Berlin
Year: 2022
Subjects: subject: health information
subject: information needs
subject: young adults
subject: cancer
subject: Information Behavior
subject: 020 Bibliotheks- und Informationswissenschaften

description: In Germany, approximately 500.000 people are newly diagnosed with cancer every year, of which only 3,3% are young adults between 18 and 39 years of age. Despite age-specific characteristics in terms of care and treatment, they receive little attention in the health infrastructure. The aim of this study is therefore to investigate information needs of young adults with cancer in Germany.Methods. Semi-structured guided online interviews were conducted with 14 young adults at the end of their treatment or in aftercare. The qualitative analysis was carried out inductively, using thematic analysis. In addition, the identified topics were analysed using the concept of the cancer patient journey. Ten themes were identified which are divided into information, service and care needs. While needs of the three identified medical themes are, for the most part, adequately answered, this does not apply to needs of the remaining seven themes. The findings clearly demonstrate that the German health infrastructure still holds a lot of potential for improvement regarding answering information, service and care needs for young adults with cancer.
(1961) Francis Watts Sharpe
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Multi-objective optimization of bio-based thermal insulation materials in building modeling
Creators: name: Torres, A.
name: Palumbo, M.
name: Jiménez, L.
name: Naked Haddad, A.
name: Boer, D.
Publisher: name: Academic Journal of Civil Engineering
Year: 2017

description: Energy efficiency in buildings is a key objective of nowadays policies. To achieve this goal, three main strategies can be implemented: modify users’ behavior, implement passive measures and implement active measures. Those strategies and the reduction of the energy consumption during the use phase imply both, an initial investment and an environmental impact. The equilibrium between them and their efficiency benefits should be evaluated in advance to any intervention. The present work implements a passive measure, an insulation layer in the building envelope, as example. Mathematical programming and multi-objective optimization methodology is used on a building-like cubicle, which energy consumption has been evaluated combining EneryPlus and JEPlus software. Polyurethane and seven commercial and experimental biobased thermal insulation materials are compared. The cost and the environmental impact associated to each solution have been quantified using the life cycle assessment methodology. The results show that bio-based materials can reduce the cost and the environmental impact compared to conventional insulating materials. In our study, hemp offered the most balanced solution, achieving a reduction of 14% and 36% in cost and environmental impact respectively for the climate in Lleida.
description: Academic Journal of Civil Engineering, Vol 35 No 2 (2017): Special Issue - ICBBM 2017
Information needs on research data creation
Creators: name: Börjesson, Lisa
name: Huvila, Isto
name: Sköld, Olle
Publisher: name: Humboldt-Universität zu Berlin
Year: 2022
Subjects: subject: Research data
subject: Data management
subject: Data reuse
subject: Information needs
subject: Paradata
subject: 020 Bibliotheks- und Informationswissenschaften

description: Researchers’ data related information needs are growing. This paper reports the findings of a study with archaeologists and cultural heritage professionals focussing on data reuse related meta-information needs. Interviews with (N=)10 archaeologists and cultural heritage professionals. Qualitative coding and content analysis. Four types of paradata needs (data on processes, e.g. data creation) are identified, including 1) scope, 2) provenance, 3) methods and 4) knowledge organisation and representation paradata. Knowledge organisation and representation paradata has been least explored both in research and practises so far. The findings point to a need to develop the understanding of the needs and means of documentation of knowledge organisation and representation. The findings contribute to the data literacy of researchers producing and using data descriptions, and to the study of how paradata can be created and used. Further, the findings indicate that distance-to-data is a significant parameter in determining whether information needs are continuous or discrete. Further, the most likely type of reuse should guide the level and type of paradata. Finally, the findings underline that in spite of the comprehensiveness of available meta-information, it will be incomplete. Complementary means — including collaboration with data creators and meta-information extraction approaches — are needed to increase information reusability.
(1962) Mary Eagle
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Targeted Replacement of the Mouse Apolipoprotein E Gene with the Common Human APOE3 Allele Enhances Diet-induced Hypercholesterolemia and Atherosclerosis
Creators: name: Knouff, Chris
name: Reddick, Robert L.
name: Quarfordt, Steven H.
name: Mezdour, Hafid
name: Najib, Jamila
name: Maeda, Nobuyo
name: Sullivan, Patrick M.
name: Aratani, Yasuaki
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: Apolipoprotein (apo) E, a constituent of several lipoproteins, is a ligand for the low density lipoprotein receptor, and this interaction is important for maintaining cholesterol and triglyceride homeostasis. We have used a gene replacement strategy to generate mice that express the human apoE3 isoform in place of the mouse protein. The levels of apoE mRNA in various tissues are virtually the same in the human apoE3 homozygous (3/3) mice and their littermates having the wild type mouse allele (+/+). Total cholesterol and triglyceride levels in fasted plasma from the 3/3 mice were not different from those in the +/+ mice, when maintained on a normal (low fat) chow diet. We found, however, notable differences in the distribution of plasma lipoproteins and apolipoprotein E between the two groups: beta-migrating lipoproteins and plasma apoB100 levels are decreased in the 3/3 mice, and the apoE distribution is shifted from high density lipoproteins to larger lipoprotein particles. In addition, the fractional catabolic rate of exogenously administered remnant particles without apoE was 6-fold slower in the 3/3 mice compared with the +/+ mice. When the 3/3 and +/+ animals were fed a high fat/high cholesterol diet, the 3/3 animals responded with a dramatic increase (5-fold) in total cholesterol compared with the +/+ mice (1.5-fold), and after 12 weeks on this same diet the 3/3 animals developed significantly (at least 13-fold) larger atherosclerotic plaques in the aortic sinus area than the +/+ animals. Thus the structural differences between human APOE3 and mouse ApoE proteins are sufficient to cause an increased susceptibility to dietary-induced hypercholesterolemia and atherosclerosis in the 3/3 mice.
Supplementary Material_Methods from Middle Holocene plant cultivation on the Atlantic Forest coast of Brazil?
Creators: name: Pezo-Lanfranco, Luis
name: Eggers, Sabine
name: Petronilho, Cecilia
name: Toso, Alice
name: Dione Da Rocha
name: Tersch, Matthew Von
name: Santos, Adriana M. P. Dos
name: Costa, Beatriz Ramos Da
name: Meyer, Roberta
name: Colonese, André Carlo
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Geochemistry
subject: FOS: Earth and related environmental sciences
subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: Description of analytical methods
Dynamic reorganization of vortex matter into partially disordered lattices
Creators: name: Bermúdez, M. Marziali
name: Eskildsen, M. R.
name: Bartkowiak, M.
name: Nagy, G.
name: Bekeris, V.
name: Pasquini, G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We report structural evidence of dynamic reorganization in vortex matter in clean NbSe$_2$ by joint small angle neutron scattering and ac-susceptibility measurements. The application of oscillatory forces in a transitional region near the order-disorder transition results in robust bulk vortex lattice configurations with an intermediate degree of disorder. These dynamically-originated configurations correlate with intermediate pinning responses previously observed, resolving a long standing debate regarding the origin of such responses.
description: 9 pages, 7 figures. To be published in Physical Review Letters
(1955) Allon Sharp
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The Propeptide Binding Site of the Bovine γ-Glutamyl Carboxylase
Creators: name: Wu, Sheue Mei
name: Geromanos, Scott
name: Stafford, Darrel W.
name: Mutucumarana, Vasantha P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: gamma-Glutamyl carboxylase is an integral membrane protein required for the posttranslational modification of vitamin K-dependent proteins. The main recognition between the enzyme and its substrates is through an 18-amino acid propeptide. It has been reported that this binding site resides in the amino-terminal third of the gamma-glutamyl carboxylase molecule (Yamada, M., Kuliopulos, A., Nelson, N. P., Roth, D. A., Furie, B., Furie, B. C., and Walsh, C. T. (1995) Biochemistry 34, 481-489). In contrast, we found the binding site in the carboxyl half of the gamma-glutamyl carboxylase. We show that the carboxylase may be cleaved by trypsin into an amino-terminal 30-kDa and a carboxyl-terminal 60-kDa fragment joined by a disulfide bond(s), and the propeptide binds to the 60-kDa fragment. The sequence of the amino terminus of the 60-kDa fragment reveals that the primary trypsin-sensitive sites are at residues 349 and 351. Furthermore, the tryptic fragment that cross-links to the propeptide also reacts with an antibody specific to the carboxyl portion of the gamma-glutamyl carboxylase. In addition, cyanogen bromide cleavage of bovine gamma-glutamyl carboxylase cross-linked to the peptide comprising residues TVFLDHENANKILNRPKRY of human factor IX yields a cross-linked fragment of 16 kDa from the carboxyl half of the molecule, the amino-terminal sequence of which begins at residue 438. Thus, the propeptide binding site lies carboxyl-terminal to residue 438 and is predicted to be in the lumen of the endoplasmic reticulum.
(1956) Sarah Aspin
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: On the Trace Product and Some Families of Languages Closed Under Partial Commutations
Creators: name: Guaiana, Giovanna
name: Restivo, Antonio
name: Salemi, Sergio
Publisher: name: Institut für Informatik, Justus-Liebig-Universität Giessen
Year: 2004

description: New automata-theoretic constructions for the product of recognizable trace languages
are given. This study leads to investigate the effect of partial (and total) commutations
on some families of recognizable languages (the Straubing-Th{\'{e}}rien's hierarchy of starfree
languages).
description: Journal of Automata, Languages and Combinatorics, Volume 9, Number 1, 2004, 61-79
Anomalous phonon redshift in K-doped BaFe2As2 iron pnictides
Creators: name: Xu, B.
name: Dai, Y. M.
name: Shen, B.
name: Xiao, H.
name: Ye, Z. R.
name: Forget, A.
name: Colson, D.
name: Feng, D. L.
name: Wen, H. H.
name: Homes, C. C.
name: Qiu, X. G.
name: Lobo, R. P. S. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: The effect of K, Co and P dopings on the lattice dynamics in the BaFe$_2$As$_2$ system is studied by infrared spectroscopy. We focus on the phonon at $\sim$ 253 cm$^{-1}$, the highest energy in-plane infrared-active Fe-As mode in BaFe$_2$As$_2$. Our studies show that the Co and P dopings lead to a blue shift of this phonon in frequency, which can be simply interpreted by the change of lattice parameters induced by doping. In sharp contrast, an unusual red shift of the same mode was observed in the K-doped compound, at odds with the above explanation. This anomalous behavior in K-doped BaFe$_2$As$_2$ is more likely associated with the coupling between lattice vibrations and other channels, such as charge or spin. This coupling scenario is also supported by the asymmetric line shape and intensity growth of the phonon in the K-doped compound.
description: 5 pages, 4 figures
Effective factors influencing individual’s shared health decision making
Creators: name: Ghorbanian Zolbin, Maedeh
name: Han, Shengnan
name: Nikou, Shahrokh
Publisher: name: Humboldt-Universität zu Berlin
Year: 2022
Subjects: subject: information avoidance
subject: information overload
subject: health literacy,
subject: shared decision-making
subject: 020 Bibliotheks- und Informationswissenschaften

description: This paper investigates the effects of information avoidance, information overload, health literacy on individuals’ shared health decision making. A research model is proposed based on sound theoretical background. Data from 155 respondents was collected via an online survey. Partial Least Squares Structural Equation Modelling (PLS-SEM) was applied to analyse the data. The findings suggest that information overload and information avoidance both exhibit negative effects on an individual’s shared health decision making behaviour, while health literary possess positive effects. We also find that information avoidance has a positive impact on information avoidance. Moreover, health literacy is negatively related to both information overload and information avoidance. The paper enhances both theoretical and empirical understanding of the effects of individuals’ health literacy, information overload and information avoidance on their shared health decision making behaviour. The results indicate that sufficient health literacy enables individuals to engage in their health decision making process and sharing their concerns with their physicians. However, information overload and information avoidance trigger negative effects which lead to individuals less involved in shared health decision making. Our results advocate more efforts to improve individual health literary as the means to mitigate the negative effects of information overload and information avoidance towards shared health decision making.
'I’m just not sure': the persistence of uncertainty in the information seeking of undergraduate students with dyslexia
Creators: name: Beveridge, Lynne
name: MacFarlane, Andrew
name: Makri, Stephann
Publisher: name: Humboldt-Universität zu Berlin
Year: 2022
Subjects: subject: University students
subject: Dyslexia
subject: Uncertainty
subject: Self-Efficacy
subject: 020 Bibliotheks- und Informationswissenschaften

description: As information seeking progresses, it is expected feelings of uncertainty surrounding, for example, the information need, what information will be useful to satisfy the need and how well the need has been satisfied will shift towards confidence and clarity. The six corollaries offered by Kuhlthau outline and explain areas where this shift can happen. However, does it happen for all groups of information-seekers? Undergraduate students with dyslexia often have lower information seeking-related self-efficacy than their peers and this can result in uncertainty persisting throughout information seeking. Retrospective naturalistic think aloud observations were held with 20 undergraduate students with dyslexia. After looking for information for one of their (self-chosen) assignments, participants were invited to explore their thoughts, feelings and actions with the researcher while watching a screen recording of their information seeking session. First, an inductive reflexive Thematic Analysis was conducted which revealed self-efficacy to be a key influence in the information seeking behaviour of undergraduate students with dyslexia. To investigate this further, a dedicated deductive analysis was conducted leveraging Kuhlthau’s six corollaries. The expected shift away from uncertainty towards clarity and confidence was found to be either delayed, disrupted or prevented by participants’ low self-efficacy surrounding selecting and spelling keywords and reading, interpreting and evaluating information online. Uncertainty persisted throughout information seeking and was rarely reduced or resolved. Key areas for additional support during information seeking for this user group are identified, including keyword selection and spelling, accurate reading and interpretation and confident evaluation of online information.
β-Dystrobrevin, a New Member of the Dystrophin Family: IDENTIFICATION, CLONING, AND PROTEIN ASSOCIATIONS
Creators: name: Peters, Matthew F.
name: Sadoulet-Puccio, Hélène M.
name: Kunkel, Louis M.
name: Froehner, Stanley C.
name: O'Brien, Kristine F.
name: Adams, Marvin E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: Dystrophin, the protein disrupted in Duchenne muscular dystrophy, is one of several related proteins that are key components of the submembrane cytoskeleton. Three dystrophin-related proteins (utrophin, dystrophin-related protein-2 (DRP2), and dystrobrevin) have been described. Here, we identify a human gene on chromosome 2p22-23 that encodes a novel protein, beta-dystrobrevin, with significant homology to the other known dystrobrevin (now termed alpha-dystrobrevin). Sequence alignments including this second dystrobrevin strongly support the concept that two distinct subfamilies exist within the dystrophin family, one composed of dystrophin, utrophin, and DRP2 and the other composed of alpha- and beta-dystrobrevin. The possibility that members of each subfamily form distinct protein complexes was examined by immunopurifying dystrobrevins and dystrophin. A beta-dystrobrevin antibody recognized a protein of the predicted size (71 kDa) that copurified with the dystrophin short form, Dp71. Thus, like alpha-dystrobrevin, beta-dystrobrevin is likely to associate directly with dystrophin. alpha- and beta-dystrobrevins failed to copurify with each other, however. These results suggest that members of the dystrobrevin subfamily form heterotypic associations with dystrophin and raise the possibility that pairing of a particular dystrobrevin with dystrophin may be regulated, thereby providing a mechanism for assembly of distinct submembrane protein complexes.
Information behaviour videos on YouTube: an exploratory content analysis, case study of INFIDEOS, and call to action
Creators: name: Hartel, Jenna
Publisher: name: Humboldt-Universität zu Berlin
Year: 2022
Subjects: subject: Dissemination of information behavior
subject: information behavior pedagogy
subject: multimedia education
subject: YouTube
subject: INFIDEOS
subject: 020 Bibliotheks- und Informationswissenschaften

description: How do landmark concepts of information behaviour appear as videos on YouTube? What do these multimedia artifacts, altogether, suggest about the information behaviour specialty? What might ideal versions of such videos be like? To create an empirical starting point for answering these timely questions, an exploratory content analysis was performed on a sample of 20 educational videos found on YouTube, focusing upon three big ideas of information behaviour: the Information Search Process (Kuhlthau, 1991), Sense-Making (Dervin, 1983) and Berrypicking (Bates, 1989). A coding frame was created with 23 categories and associated subcategories. SurveyMonkey was used to capture, tabulate and present the data. Due to space limitations, not all categories are included in the findings, which are reported as themes with commentary. YouTube’s information behaviour offerings are: cluttered by look-alike videos; uneven in coverage; dominated by librarians and students; and short on scholarly authority. Though singular, featured concepts can be treated thoroughly, most videos have a narrow focus; no scholarly apparatus; and disregard information behaviour’s legacy and culture. Following the content analysis, the author’s YouTube channel of Information Science videos, INFIDEOS, is profiled with attention to its information behaviour resources. Throughout, general video-making strategies are provided.
A Calcium-dependent Tyrosine Kinase Splice Variant in Human Monocytes: ACTIVATION BY A TWO-STAGE PROCESS INVOLVING ADHERENCE AND A SUBSEQUENT INTRACELLULAR SIGNAL
Creators: name: Hunter, Deborah
name: Li, Xiong
name: Haskill, J. Stephen
name: Morris, John
name: Earp, H. Shelton
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Freshly isolated human monocytes do not express p125(FAK) but upon adherence to substrata activate the highly related calcium-dependent tyrosine kinase (CADTK), also known as Pyk2, CAKbeta, RAFTK, and FAK2. The monocyte CADTK was 5 kDa smaller than protein from epithelial cells; isolation and sequencing of the monocyte CADTK cDNA revealed a predicted 42-amino acid deletion between the two proline-rich domains of the enzyme. The nucleic acid sequence suggests that the deletion is caused by alternative RNA splicing. This species was also found in T and B lymphocytes and appears to be the predominant form of cytoskeletal associated tyrosine kinase in non-neoplastic, circulating, hematopoietic cells. CADTK was not activated when monocytes maintained in suspension were treated with agents that produce an intracellular calcium (thapsigargin) or protein kinase C (phorbol 12-myristate 13-acetate) signal including a chemokine, RANTES, that binds to the HIV co-receptor, CCK5. In contrast, monocyte adherence to tissue culture plastic-stimulated CADTK tyrosine phosphorylation, a process that was enhanced by thapsigargin, phorbol 12-myristate 13-acetate, and RANTES but that was completely blocked by preincubation with cytochalasin D. When compared with plastic, adherence to fibronectin- or collagen-coated surfaces produced only minimal CADTK activation but permitted significant stimulation by added thapsigargin. These data suggest that in a cell type that lacks p125(FAK), CADTK plays an early role in post-adherence signaling. Its activation involves two stages, cytoskeletal engagement, which is permissive, and co-stimulatory signals (calcium or protein kinase C) generated by extensive cell surface engagement, agonists, or inflammatory chemokines.
(1957) Charlotte Booth
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Supplementary Material_Tables from Middle Holocene plant cultivation on the Atlantic Forest coast of Brazil?
Creators: name: Pezo-Lanfranco, Luis
name: Eggers, Sabine
name: Petronilho, Cecilia
name: Toso, Alice
name: Dione Da Rocha
name: Tersch, Matthew Von
name: Santos, Adriana M. P. Dos
name: Costa, Beatriz Ramos Da
name: Meyer, Roberta
name: Colonese, André Carlo
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Geochemistry
subject: FOS: Earth and related environmental sciences
subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: Results Tables
Diffuse flux of PeV neutrinos from centrifugally accelerated protons in active galactic nuclei
Creators: name: Dey, Rajat K.
name: Basak, Animesh
name: Ray, Sabyasachi
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Evidence for high-energy astrophysical PeV neutrinos has been found in the IceCube experiment from an analysis with a 7.5 year (2010 - 2017) data. Active galactic nuclei (AGN) are among the most prominent objects in the universe, and are widely speculated to be emitters of ultra-high-energy (UHE) cosmic rays with proton domination. Based on the standard two-step LLCD mechanism of particle acceleration, a transformation of energy occurs from AGN's central super-massive black hole (SMBH) rotation to high-energy protons. Protons can be accelerated up to $\sim 0.1$ EeV energies and above, and might generate PeV neutrinos in the energy range $1$--$10$~ PeV through plausible hadronic interactions. The theoretically estimated revised extragalactic diffuse muon neutrino flux employing the "luminosity-dependent density evolution (LDDE)" model for the AGN luminosity function (LF) is found consistent with the IceCube level if only a fraction, $6.56\%$ of the total bolometric luminosity (BL) of AGN is being realizable to power the PeV neutrinos. In the $Λ$~CDM cosmological framework with the LDDE modeled LF and photon index distribution, about $5.18\%$ of the total BL is enough to power the IceCube neutrinos.
description: 8 pages, 0 figures, Accepted for publication in Europhys. Letts
La Kulturwissenschaftliche Bibliothek Warburg in Amburgo (1930)
Creators: name: Fritz Saxl, Michela Maguolo
Publisher: name: La Rivista di Engramma
Year: 2023
Subjects: Fritz Saxl
Aby Warburg
Warburg Library of Cultural Sciences

description: Fritz Saxl’s article Die Kulturwissenschaftliche Bibliothek Warburg in Hamburg was published in Forschungsinstitute, ihre Geschichte, Organisation un Ziele, edited by L. Brauer, A. Mendelssohn Bartholdy und A. Meyer, (Band II, Hamburg 1930, 355-358), is here translated for the first time into Italian by Michela Maguolo.
Informational balance
Creators: name: Samson, Hugh Kevin
Publisher: name: Humboldt-Universität zu Berlin
Year: 2022
Subjects: subject: informational balance
subject: Information Behavior
subject: slow movement
subject: slow perspective
subject: 020 Bibliotheks- und Informationswissenschaften

description: Evoking both activity and stillness, balance has been a concept of interest within academic research for centuries. In recent decades, the concept of balance has also garnered attention within information science. This conceptual paper is based upon a synthesis of selected articles and themes concerning the subject of balance as well as an analysis of recent writings from the field of information science. It draws in particular from work regarding the construct of informational balance. Information scientists have analysed the shifting balance of scientific information flows between nations as well as the balance of intellectual trade between information science and its cognate disciplines. Studies have also examined strategies to identify and implement balanced, scalable and sustainable online instruction within information institutions, and investigated issues of work-life balance among information professionals and scientists. The construct of informational balance has emerged as a particularly noteworthy application of the concept of balance, and subsequent to its origin it has been taken up by a number of additional information scientists. In shining a light on informational balance this paper aspires to lay the groundwork for fresh elaboration of the construct and for future innovative research in this area.
A Model for Ku Heterodimer Assembly and Interaction with DNA: IMPLICATIONS FOR THE FUNCTION OF Ku ANTIGEN
Creators: name: Reeves, Westley H.
name: Wang, Jingsong
name: Dong, Xingwen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Ku autoantigen, a heterodimer of 70- and 80-kDa subunits, is a DNA end-binding factor critical for DNA repair. Two domains of p70 mediate DNA binding, one on the C-terminal and one on the N-terminal portion. The latter must dimerize with p80 in order to bind DNA, whereas the former is p80-independent. Both must be intact for end binding activity in gel shift assays. To evaluate the role of p80 in DNA binding, deletion mutants were co-expressed with full-length p70 using recombinant baculoviruses. We show by several criteria that amino acids 371-510 of p80 interact with p70. Both of the p70 dimerization domains bind to the same region of p80, but apparently to separate sites within that region. In DNA immunoprecipitation assays, amino acids 179-510 of p80 were required for p80-dependent DNA binding of p70, whereas in gel shift assays, amino acids 179-732 were necessary. Interestingly, both the p80-dependent and the p80-independent DNA binding sites preferentially bound to DNA ends, suggesting a model in which a single Ku heterodimer may juxtapose two broken DNA ends physically, facilitating their rejoining by DNA ligases.
(1959) Mary [Booth]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Soft Matter Perspective on Protein Crystal Assembly
Creators: name: Fusco, Diana
name: Charbonneau, Patrick
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Biomolecules (q-bio.BM)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Crystallography may be the gold standard of protein structure determination, but obtaining the necessary high-quality crystals is also in some ways akin to prospecting for the precious metal. The tools and models developed in soft matter physics to understand colloidal assembly offer some insights into the problem of crystallizing proteins. This topical review describes the various analogies that have been made between proteins and colloids in that context. We highlight the explanatory power of patchy particle models, but also the challenges of providing guidance for crystallizing specific proteins. We conclude with a presentation of possible future research directions. This article is intended for soft matter scientists interested in protein crystallization as a self-assembly problem, and as an introduction to the pertinent physics literature for protein scientists more generally.
description: 11 pages, 3 figures, 2 table. Accepted for publication in Colloids and Surfaces B: Biointerfaces
(1953) Susan A [Buchanan]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(1951) Ann Buchanan
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Student experience of digital learning tools: information literacy training in higher education
Creators: name: Skov, Mette
name: Svarre, Tanja
name: Lykke, Marianne
Publisher: name: Humboldt-Universität zu Berlin
Year: 2022
Subjects: subject: Information literacy
subject: Information seeking
subject: Higher education
subject: Academic libraries
subject: 020 Bibliotheks- und Informationswissenschaften

description: The paper presents a qualitative study of how students in higher education experience the use of digital learning objects as part of information literacy training. The study is inspired by the phenomenographical method and take a second-order perspective asking how students experience information literacy training and digital learning tools. The study builds on seven focus-group interviews with a total of 29 students from law, engineering, and nursing. The first part of the analysis presents results on students’ experience of the digital learning tools across the cases with focus on student motivation. The second part of the analysis focuses on the roles of the different actors in information literacy building. The analysis illustrates how the use of digital learning tools and face-to-face information literacy training is deeply related to the roles of the different actors taking part in the information literacy practice. The academic librarian is almost invisible to the students in two of the three cases, but student interaction with the digital learning tools promote visibility. The findings confirm related research on the importance of integrating information literacy training into curriculum and nuances our understanding of how students experience information literacy training and digital learning tools.
Is anybody in there?: Towards a model of affect and trust in human – AI information interactions
Creators: name: Pawlick-Potts, Danica
Publisher: name: Humboldt-Universität zu Berlin
Year: 2022
Subjects: subject: trust
subject: human-computer interaction
subject: information interactions
subject: conceptual models
subject: 020 Bibliotheks- und Informationswissenschaften

description: Advancements in search engines that utilize machine learning increase the likelihood that users will perceive these systems as worthy of trust. The nature and implications of trust in the context of algorithmic systems that utilize machine learning is examined and the resulting conception of trust is modelled. While current artificial intelligence does not meet the requirements of moral autonomy necessary to be considered trustworthy, people may still engage in misplaced trust based on the perception of moral autonomy. Users who place their trust in algorithmic systems limit their critical engagement with, and assessment of, the information interaction. A preliminary high-level model of trust’s role in information interactions adapting Ingwersen and Jarvelin’s Integrative Model for Interactive Information Seeking and Retrieval is proposed using the Google search engine as an example. We need to recognize that is it possible for users to react to information systems in a social manner that may lead to the formation of trust attitudes. As information professionals we want to develop interventions that will encourage users to stay critically engaged with their interactions with information systems, even when they perceive them to be autonomous.
A Single Cysteine, Cys-64, Is Essential for Assembly of Tenascin-C Hexabrachions
Creators: name: Luczak, Jennifer A.
name: Schwarzbauer, Jean E.
name: Redick, Sambra D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Tenascin-C is a large, multimeric extracellular matrix protein that is found in a variety of tissues and can have profound effects on cell adhesion. It is secreted from cells as a hexamer of six identical chains called a hexabrachion. Disulfide bonding among tenascin subunits mediates intracellular assembly into hexamers. The amino-terminal assembly domain consists of heptad repeats and at least six cysteine residues (Cys-64, -111, -113, -140, -146, -147) that could be involved in multimerization. We have now determined the requirements for these cysteine residues during hexamer assembly. Our results show that only Cys-64 is required to form the hexameric structure. Mutation of Cys-64 to glycine resulted in release of trimer intermediates, which probably form via the heptad repeats, but no hexamers were secreted. In contrast, individual or pairs of mutations of each of the other cysteines had no effect on tenascin hexamer formation, and inclusion of any other cysteine mutations along with C64G did not further disrupt the multimer pattern. However, when all six cysteines were mutated, monomers were the major extracellular form. Together, these results show that trimers are an intermediate of tenascin-C assembly and that Cys-64 is essential for formation of hexabrachions.
(1952) John Buchanan
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Simulation techniques for the study of the manoeuvring of advanced rotorcraft configurations
Creators: name: Rutherford, Stephen
Publisher: name: University of Glasgow
Year: 1997

description: Inverse simulation is a technique by which the necessary control actions can be calculated for a vehicle to perform a particular manoeuvre. The manoeuvre definition is thus the input to the problem, and the output is a time history of the control motions. The realism of a result is clearly dependent on the fidelity and sophistication of the vehicle mathematical model. Present inverse simulation algorithms are limited by being model specific and only able to accommodate models of restricted complexity. For helicopters specifically the models used in inverse simulation are, in general, rudimentary in nature. The existing inverse simulation algorithm at Glasgow University, "Helinv" is specific to the helicopter model, "HGS". Though HGS is very advanced by comparison with other inverse simulation helicopter models, it lags far behind the state of the art in conventional simulation. The principal aims of this research were therefore twofold: to develop a robust, generic inverse simulation algorithm, "Genisa"; and to develop a state of the art individual blade helicopter rotor model, "Hibrom". Naturally verification and validation were integral to these aims. These objectives having been achieved the intention was to demonstrate the flexibility of Genisa and the value of Hibrom by performing inverse simulations of various rotorcraft configurations. As well as representing a novel tool in rotorcraft simulation, the development of a flexible inverse simulation algorithm which can accommodate complex models extends the boundaries of inverse problems in general. Genisa has proven to be both flexible and robust. Hibrom has been verified, validated and - using Genisa - successfully used in inverse simulation. The advantages of an individual blade model in inverse simulation have been demonstrated by comparing results with the disc model, HGS. Inverse simulations have been performed for various rotorcraft configurations identifying the respective benefits of the different vehicles. In all respects the aims identified above have been met in full.
An Apical PDZ Protein Anchors the Cystic Fibrosis Transmembrane Conductance Regulator to the Cytoskeleton
Creators: name: Short, Douglas B.
name: Kreda, Silvia M.
name: Bretscher, Anthony
name: Stutts, M. Jackson
name: Boucher, Richard C.
name: Milgram, Sharon L.
name: Trotter, Kevin W.
name: Reczek, David
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: The function of the cystic fibrosis transmembrane conductance regulator (CFTR) as a Cl- channel in the apical membrane of epithelial cells is extensively documented. However, less is known about the molecular determinants of CFTR residence in the apical membrane, basal regulation of its Cl- channel activity, and its reported effects on the function of other transporters. These aspects of CFTR function likely require specific interactions between CFTR and unknown proteins in the apical compartment of epithelial cells. Here we report that CFTR interacts with the recently discovered protein, EBP50 (ERM-binding phosphoprotein 50). EBP50 is concentrated at the apical membrane in human airway epithelial cells, in vivo, and CFTR and EBP50 associate in in vitro binding assays. The CFTR-EBP50 interaction requires the COOH-terminal DTRL sequence of CFTR and utilizes either PDZ1 or PDZ2 of EBP50, although binding to PDZ1 is of greater affinity. Through formation of a complex, the interaction between CFTR and EBP50 may influence the stability and/or regulation of CFTR Cl- channel function in the cell membrane and provides a potential mechanism through which CFTR can affect the activity of other apical membrane proteins.
Binding of Endonuclease VII to Cruciform DNA: VISUALIZATION IN THE ELECTRON MICROSCOPE
Creators: name: Kupfer, Christian
name: Kemper, Börries
name: Lee, Suman
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: The binding of Holliday structure resolving endonuclease VII to cruciform DNA was studied in the electron microscope. The protein was found to bind either to the junction or to one of the arms or an end of one of the arms of the construct. The amount of bound protein was determined by measuring the size of the complexes. On average, one complex containing three dimers was found per one molecule of cruciform DNA.