cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: „mit gebundene Hände kann man nicht schwimmen, oder?“ – Die Rolle der Vorstellungsbilder für die Bedeutungsaushandlung wahrnehmungsbasierter Redewendungen bei Lernenden mit der Erstsprache Farsi
Creators: name: Schmorré, Madeleine
Publisher: name: UNSPECIFIED
Year: 2024

description: Die vorliegende Arbeit beschäftigt sich mit der Verstehbarkeit idiomatischer Redewendungen in der Fremdsprache Deutsch. Sie zeigt auf, wie Deutschlernende mit der Erstsprache Farsi die in den Redewendungen ausgedrückten phraseologischen Bilder bei der Bedeutungsaushandlung einbeziehen. Hierfür wird eine besondere Gruppe innerhalb der Redewendungen in den Blick genommen, die aus kognitionslinguistischer Perspektive als ohne spezifisches Vorwissen verstehbar gilt. Ihre semantische Besonderheit besteht darin, dass die darin enthaltenen Bilder wahrnehmungsbasierte bzw. die sensomotorische Ebene betreffende Erfahrungen aufgreifen und somit Vorstellungen hervorrufen, aus denen sich die Bedeutungen der Redewendungen ableiten lassen. Für die qualitative Untersuchung wurden mittels Fragebogen und Gruppeninterviews Daten erhoben bzw. Antworten und Gespräche von Deutschlernenden mit Erstsprache Farsi gesammelt. Die gewonnenen Daten wurden inhaltsanalytisch hinsichtlich der Vorstellungsbilder und ihrer Rolle, die sie beim Aushandeln der Bedeutungen verschiedener deutscher Redewendungen spielen, untersucht. Die Ergebnisse bestätigen die prinzipielle Verstehbarkeit wahrnehmungsbasierter Redewendungen und zeigen zudem, dass sowohl die Bilder der präsentierten deutschen Redewendungen als auch bildäquivalente, persische Redewendungen die Bedeutungsannahmen beeinflussen. Für das Sprachenpaar Deutsch-Farsi wurden außerdem Redewendungspaare ermittelt und vor dem Hintergrund der Zuschreibung der Bildäquivalenz diskutiert, was zu einem besseren Verständnis des Verstehensprozesses bei idiomatischen Redewendungen beiträgt. Die Ergebnisse belegen somit nicht nur die große Beteiligung der Vorstellungsbilder bei der Bedeutungsaushandlung, sondern offenbaren auch das Spektrum an bildäquivalenten Ausdrücken, das beim Verstehen von fremdsprachlichen Redewendungen hinzugezogen werden kann.
title: Einführung in die Wissenschaften
title: Wissenschaftstypen - Deutungskämpfe - Interdisziplinäre Kooperation
titleType: Subtitle
Creators: name: Kogge, Werner
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: Pluralistische Wissenschaftstheorie
subject: Wissenschaftstypen
subject: interdisziplinäre Kooperation
subject: 100 Philosophie und Psychologie::100 Philosophie::100 Philosophie und Psychologie

description: Pluralistische Wissenschaftstheorie ist kein etabliertes Format. Herkömmliche Darstellungen nehmen meist die Perspektive einer einzelnen Ausprägung von Wissenschaft ein, verbunden mit impliziten Wertungen und unbefragten Präferenzen. So belasten Kämpfe um Deutungshoheit notorisch die kooperative Forschung. Werner Kogge entfaltet demgegenüber einen neuen Ansatz: Er zeichnet nach, wie sich aus mehreren historischen Quellen verschiedene Typen wissenschaftlicher Forschung ausprägten, und wie diese Typen heute praktiziert werden. So entsteht ein Bild unterschiedlicher, aber gleichberechtigter Formen wissenschaftlicher Forschungspraxis, ohne hierarchische Staffelung oder eine evolutionäre Entwicklungslinie. Mit dieser Pluralität kommt auch eine neue Form von Interdisziplinarität in den Blick: strukturell, modular und praxisbezogen.
title: Kontaktlinsen-assoziierte Keratitis: Fusarium solani als tückische Ursache
Creators: name: Armeni, Zaira Eleni
name: Kohlhaas, M.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Eine Fusarium-Keratitis ist eine schwerwiegende HH-Entzündung durch Fadenpilze. In den Tropen stellt dies eine häufige Ursache für einen Visusverlust dar, in gemäßigten Klimazonen ist diese dagegen sehr selten. Hauptrisikofaktoren sind das Tragen von Kontaktlinsen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 182. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte
Beyond size: exploring the origins of anti-fat attitudes and paving the way away from them
Creators: name: Jovančević, Ana
name: Assche, Jasper Van
Publisher: name: University of Limerick
Year: 2025
Subjects: classificationCode: 52
subject: Psychology
subject: FOS: Psychology

description: This article presents a review of the complex web of factors driving anti-fat attitudes and offers a roadmap for targeted interventions. We delve into the impact of early family influences on the formation of anti-fat biases, revealing how biases often take root in childhood. The scope of our review then broadens to examine how intersections of gender, sexuality, race, and age intensify anti-fat stigma, with added layers of socioeconomic disparities, pervasive media portrayals and culture providing further vectors of interaction. We also analyze the psychological dimensions of belief within perceivers, such as internalized ideals and broader social worldviews, that reinforce these biases. Our synthesis highlights the importance of a holistic approach in future research, urging attention to intersecting influences and the cumulative impact of these factors from an early age. By addressing these dimensions and promoting diverse intervention strategies, we aim to provide actionable insights to reduce anti-fat biases across varied populations.
title: Kontaktlinsen als Risikofaktor einer Pilzkeratitis – Ergebnisse aus dem Deutschen Pilz-Keratitis-Register
Creators: name: Roth, Mathias
name: Geerling, G.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Die mykotische Keratitis ist ein sehr ernst zu nehmendes ophthalmologisches Krankheitsbild mit potentiell visusbedrohendem Verlauf. Bislang ist die Erkrankung in Deutschland verhältnismäßig selten, weltweit nimmt die Inzidenz jedoch zu, wahrscheinlich aufgrund der steigenden[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 182. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte
Eleodes loretensis Blaisdell 1923
Creators: name: Pérez-Hernández, Cisteil Xinum
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Tenebrionidae
Eleodes
Eleodes loretensis

description: - Eleodes loretensis Blaisdell, 1923
Paratype: 1 [unknown sex]. MEXICO: Baja California, Loreto, 20/V/1921. Col. E. P. Vanduzee. Conservation status: Complete, well-preserved.
description: Published as part of Pérez-Hernández, Cisteil Xinum, 2017, An annotated catalogue of the Coleoptera types deposited in the National Insect Collection (CNIN) of the National Autonomous University of Mexico, pp. 1-128 in Zootaxa 4288 (1) on page 114, DOI: 10.11646/zootaxa.4288.1.1, http://zenodo.org/record/1010410
title: Customized-Crosslinking bei Keratokonus
Creators: name: Elling, Matthias
name: Pradel, L.
name: Dick, H.B.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Methoden: Bei diesem Patienten wird das Customized-Crosslinking mit dem Mosaic-System der Fa. Avedro ohne Epithelabrasio und Sauerstoffzugabe über eine Spezialmaske im März 2019 durchgeführt. Hierbei wird ein individuelles Energieprofil verwendet. Dabei wird der Mittelpunkt der Ektasie[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 182. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte
title: Bei welcher Keratektasie ist ein corneales Crosslinking effizienter?
Creators: name: Gökel, Gürol
name: Kohlhaas, M.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Das corneale Crosslinking ist eine etablierte und effektive Therapie eines progredienten Keratektasie. Das Ziel dieser retrospektiven Studie ist die Effizient des Crosslinking bei verschiedenen Formen der Keratektasie zu untersuchen. Methoden: Insgesamt werden in dieser Studie die Daten[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 182. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte
title: Multimodale Bildgebung des vorderen Augenabschnitts
Creators: name: Bachmann, Björn
name: Siebelmann, S.
name: Matthaei, M.
name: Zwingelberg, S.
name: Cursiefen, C.
name: Wiedemann, J.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Aufnahmen der Hornhaut mit neuen Swept-source-basierten OCT-Geräten bieten neue Möglichkeiten der cornealen Morphometrie und Tomographie. Methoden: Einführung in das Thema und Präsentation klinischer Beispiele, bei denen die neue Technik diagnostische Vorteile bringt.[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 182. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte
title: Partielle oder komplette Bindehautdeckung – Indikation und operatives Vorgehen
Creators: name: Kohlhaas, Markus
name: Perdikakis, G.
name: Fili, S.
name: Vastardis, I.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Bindehautdeckungen werden heutzutage nur noch selten praktiziert. Sie haben ihre Indikation fast nur noch bei chronischen Oberflächenproblemen, die dauerhaft gelöst werden müssen und bei denen Verbands-Kontaktlinsen, Amnionaufnähungen und Keratoplastiken ausscheiden.[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 182. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte
title: Tageszeitliche Schwankungen von Hornhautdicke, Refraktion und Glare-Visus bei der fortgeschrittenen Fuchs-Endotheldystrophie
Creators: name: Matthaei, Mario
name: Loreck, N.
name: Adler, W.
name: Siebelmann, S.
name: Rokohl, A. C.
name: Heindl, L.M.
name: Cursiefen, C.
name: Bachmann, B.O.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Im fortgeschrittenen Stadium der Fuchs-Endotheldystrophie (FED) kommt es zur subjektiven Sehverschlechterung insbesondere in den Morgenstunden. Ziel der vorliegenden prospektiven Studie war die Evaluation der tageszeitlichen Schwankungen von Hornhautdicke, Refraktion und (Glare-)Visus bei[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 182. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte
title: Die unbedachte Gefahr: der schmerzlose Fremdkörper
Creators: name: Zwingelberg, Sarah Barbara
name: Hamrah, P.
name: Hamprecht, A.
name: Walker, S.
name: Bachmann, B.
name: Cursiefen, C.
name: Roters, S.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Notfallmäßige Vorstellung von einem neun Jahre alten Patienten, der sich mit schmerzlosem Fremdkörper und Visusminderung vorstellte. Es zeigte sich ein Infiltrat am linken Auge unklarer Genese. Daraufhin wurde eine Breitspektrum-Antibiose als topische Therapie eingeleitet. Es erfolgten[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 182. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte
title: Kanalikulitis als Ursache einer chronischen Keratitis mit konsekutiver Keratoplastik à chaud?
Creators: name: Stirbu, Madalina
name: Wölfelschneider, P.
name: Kohlhaas, M.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Die Kanalikulitis ist eine seltene Infektion des Tränenkanälchen (2-4% der Krankheitsbilder der Tränenwege= TW), die meist unilateral und an einem Kanalikulus auftritt. Symptome wie Epiphora, Bindehautrötung, eitriges/nicht eitriges Sekret, Verhärtung[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 182. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte
Clostridium botulinum NEUROTOXIN TYPE E BINDING DOMAIN FROM Pichia pastoris AS A RECOMBINANT VACCINE CANDIDATE
Creators: name: Loveless, Bonnie McNabb
Publisher: name: Maryland Shared Open Access Repository
Year: 2003

description: Botulinum toxin, one of the deadliest substances known to exist, is a complex protein produced by the bacterium Clostridium botulinum. The toxin prevents the release of acetylcholine from nerve terminals resulting in a severe and potentially fatal muscular paralysis. This occurs as the result of a series of molecular events orchestrated individually by each of the three toxin subunits: binding to the nerve cell, internalization into the cytoplasm, and catalysis of one of the key components of the exocytic fusion complex. Prevention of any step in the process of intoxication could prevent the onset of the disease. A pentavalent vaccine with Investigational New Drug (IND) status is currently available to protect individuals considered to be "at-risk" for toxin exposure. This group includes laboratory workers who handle the bacteria and military personnel on the battlefield who may face a threat with the toxin as a bio-weapon. The vaccine is a formalin-fixed toxoid produced from crude culture supernatants of five of the seven known serotypes of C. botulinum. Shortcomings associated with this vaccine include a limited supply, expensive cost of production, and undesirable side effects upon administration. The Department of Immunology and Molecular Biology, Division of Toxinology at the United States Army Medical Research Institute of Infectious Diseases (USAIVIRIED) has focused on a toxin subunit in an effort to produce a new-generation vaccine. Synthetic genes encoding non-toxic, carboxy—terminal fragments of the C botulinum neurotoxins (rBoNT/(Hc) A, B, C₁, and F have been expressed in Pichia pastoris and administration of these fragments have protected mice from challenge of the respective serotype. A synthetic gene encoding the fragment C of C. botulinum serotype E was transformed into P. pastoris. The expressed rBoNT/E(Hc) was purified and used to immunize three groups of mice once, twice, or three times respectively. Each vaccination group was subsequently subjected to 1000, 10,000, or 100,000 times the 50% mouse lethal dose (MLD₅₀) of C. botulinum type E toxin. Mice that were vaccinated three times with 1μg of rBoNT/E(Hc) survived the highest level of toxin challenge of 100,000 times the MLD₅₀. Pooled sera from the same vaccination group produced neutralizing antibodies of 48.2 IU/mL in mice. In a separate potency assay to determine the ability to elicit protective immunity, mice challenged with 1000 MLD₅₀ of BoNT/E toxin had an ED₅₀ of 193 ng with rBoNT/E(Hc) while 1.61 μg of the pentavalent toxoid vaccine was required for the same level of protection.
Visualiztionf of Feminism
Creators: name: Changhao Ying
Publisher: name: Zenodo
Year: 2020
Subjects: visualization

description: This is an individual project about analysis feminism by visualizing the data in html. The webpage can be entered through file:///C:/Users/KJ/Desktop/DATS%206401%20-%20Final%20Project%20-%20Changhao%20Ying/index.html.
Crustose Corallinales (Melobesiodeae) of the Caribbean Sea and West Indies
Creators: name: Lutz, Susan M.
Publisher: name: Maryland Shared Open Access Repository
Year: 2005

description: The suborder Melobesiodeae of the Corallinales (Rhodophyta) from the Caribbean Sea and West Indies has been studied and analyzed for morphological descriptions as well as anatomical and cytological differentiation between the three genera, Sporolithon, Lithothamnion and Mesophyllum typically found in tropical seas. A full taxonomic analysis for this group in this geographic area has not previously been published. The added facet of scanning electron microscopy (SEM) and its potential application as a tool for future research in this sometimes difficult group is also presented. It is tentatively concluded that SEM examination provides strong supporting information to the basic paraffin slide preparation technique, especially with regard to cell and filament growth and dimension. The SEM measurement methods used in this study should undergo further investigation in a second group of the Corallinales. A comparison between the two groups will provide further validity to the method. It is also likely that continuing work will provide valuable insight into coralline carbonate structure.
Helops noguerai Doyen 1988
Creators: name: Pérez-Hernández, Cisteil Xinum
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Tenebrionidae
Helops
Helops noguerai

description: - Helops noguerai Doyen, 1988
Paratype: 1 [unknown sex]. MEXICO: Jalisco, 5 km NO de El Tuito, 10/IX/1987. Col. F. A. Noguera, Golpeando Quercus sp.; FANM 6820.
Conservation status: Complete, well-preserved.
description: Published as part of Pérez-Hernández, Cisteil Xinum, 2017, An annotated catalogue of the Coleoptera types deposited in the National Insect Collection (CNIN) of the National Autonomous University of Mexico, pp. 1-128 in Zootaxa 4288 (1) on page 114, DOI: 10.11646/zootaxa.4288.1.1, http://zenodo.org/record/1010410
Development of 5-hydroxybenzothiophene derivatives as multi-kinase inhibitors with potential anti-cancer activity
Creators: name: El-Rahman, Yara A Abd
name: Chen, Po-Jen
name: ElHady, Ahmed K
name: Chen, Shun-Hua
name: Lin, Hsin-Chieh
name: El-Gamil, Dalia S
name: Aboushady, Youssef
name: Abadi, Ashraf H
name: Engel, Matthias
name: Abdel-Halim, Mohammad
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Aim: Chemoresistance in cancer challenges the classical therapeutic strategy of ‘one molecule-one target’. To combat this, multi-target therapies that inhibit various cancer-relevant targets simultaneously are proposed. Methods & results: We introduce 5-hydroxybenzothiophene derivatives as effective multi-target kinase inhibitors, showing notable growth inhibitory activity across different cancer cell lines. Specifically, compound 16b, featuring a 5-hydroxybenzothiophene hydrazide scaffold, emerged as a potent inhibitor, displaying low IC50 values against key kinases and demonstrating significant anti-cancer effects, particularly against U87MG glioblastoma cells. It induced G2/M cell cycle arrest, apoptosis and inhibited cell migration by modulating apoptotic markers. Conclusion: 16b represents a promising lead for developing new anti-cancer agents targeting multiple kinases with affinity to the hydroxybenzothiophene core. Several 5-hydroxybenzothiophene derivatives were synthesized and assessed as multi-target kinase inhibitors. The 5-hydroxybenzothiophene amide derivatives 4, 6, 7 and 10 displayed selective inhibition toward haspin. The hydrazide derivative 16b displayed the most potent multi-target kinase inhibition, with IC50 values of 11, 87, 125.7, 163, 284 and 353.3 nM against Clk4, DRAK1, haspin, Clk1, Dyrk1B and Dyrk1A respectively. 16b displayed broad spectrum anticancer activity, as it could inhibit the growth of HCT-116, A549, U87MG and Hela cells, with the highest growth inhibition observed in the U87MG cells (IC50 = 7.2 μM). 16b induces G2/M cell cycle arrest, apoptosis and inhibits migration in U87MG cells.
title: Was ist schief gegangen? Gründe für das Scheitern bisheriger Retina-Implant-Systeme
Creators: name: Walter, Peter
name: Schaffrath, K.
name: Lohmann, T.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Die beiden kommerziellen Retina-Implant-Systeme Argus II und Alpha-AMS sind nicht mehr erhältlich. Second-Sight konzentriert sich ganz auf ein kortikales Implantat, die Retina Implant AG hat ihren Betrieb eingestellt. Es sollen hier die Ergebnisse der Systeme kurz zusammengefasst werden[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 182. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte
DIRECTED EVOLUTION OF A THERMOSTABLE PECTIN METHYLESTERASE FOR USE IN A SUGAR BEET BIOREFINARY
Creators: name: Lyons, Margaret J.
Publisher: name: Maryland Shared Open Access Repository
Year: 2013

description: Worldwide demand for biofuel is increasing. Agricultural waste like sugar beet pulp is a sustainable, abundant, inexpensive, and readily saccharificable biomass feedstock. Pectin is a complex polymer abundant in plant cell walls. Pectin methylesterase (PME) catalyzes the hydrolysis of pectin methylester groups into methanol. Application of PME to sugar beet pectin yields biomethanol and enables further enzymatic conversion into other biofuels. The optimal temperature of PME is 50°C, yet sugar beet pulp exits processing at 60°C. To utilize this latent heat PME must be active at 60°C. This study uses directed evolution methods (site-directed mutagenesis and error-prone PCR) to combine known thermostable mutations to create one multiplymutant thermostable PME. The final clone, JL25, exhibited 100% activity at 65°C and enhanced activity on sugar beet pulp. These results confirm past research suggesting the additive effects of multiple mutations, and provide an example of an amino acid substitution with background-dependent phenotypic effects.
title: Akute Visusminderung bei einer 62-jährigen Patientin afrikanischer Herkunft
Creators: name: Dliga, Mariem
name: Kohlhaas, M.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Die Sichelzellanämie stellt in Mitteleuropa eine seltene Ursache einer proliferativen Retinopathie dar. Da die Sichelzellanämie jedoch gehäuft bei Patienten aus Schwarzafrika, Mittelamerika, dem Mittelmeerraum und dem Mittleren Osten auftritt, ist mit einer erhöhten [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 182. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte
STRUCTURE AND THERMODYNAMICS OF ADENINE BINDING TO THE RICIN A-CHAIN
Creators: name: Machiesky, LeeAnn M.
Publisher: name: Maryland Shared Open Access Repository
Year: 2006

description: Ricin is a type II ribosome inactivating protein from the castor bean that presents a significant bioterrorism threat. Due to its high availability and toxicity, there is a need for the development of therapeutics against the toxin. The ricin A-chain (RTA) is an N- glycosidase that cleaves a specific adenine base from a conserved loop in 28S rRNA. Free adenine is an uncompetitive inhibitor of this reaction. Using a combination of fluorescence and X-ray crystallography, I investigated the energetics and active site conformational changes that occur with adenine binding to RTA. I solved an improved RTA-adenine co-crystal structure diffracting to a resolution of 1.94 A, which shows different molecular interactions than previous structures. I also examined the effects of temperature 5-30°C and pH 4-8 on purine binding to RTA. The Kᴅ for adenine binding to RTA was 7.0 x 10ˉ⁴ M at pH 7.4, 25 °C.
title: Warum scheitern Ablatiooperationen?
Creators: name: Koutsonas, Antonios
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Es sind mittlerweile über 90 Jahre vergangen, als der Schweizer Ophthalmologe Gonin als Erster erkannte, dass ein Netzhautloch die Ursache der Netzhautablösung darstellt. Trotz der ständigen Weiterentwicklung der operativen Verfahren, liegt die primäre anatomische Erfolgsrate [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 182. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte
title: Resultate der Pars-plana-Vitrektomie mit ILM-Peeling und ILM-Flap-Technik in der Behandlung durchgreifender idiopathischer Makulaforamina
Creators: name: Hermel, Martin
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Das durchgreifende idiopathische Makulaforamen hat oft erhebliche funktionelle Einbußen zu Folge. Die Pars-plana-Vitrektomie stellt eine effektive Behandlungsmodalität dar, wobei ein Peeling der Inneren Limitierenden Membran der Netzhaut mit besseren Verschlußraten bis 90%[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 182. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte
Helops scintillatus Doyen 1988
Creators: name: Pérez-Hernández, Cisteil Xinum
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Tenebrionidae
Helops
Helops scintillatus

description: - Helops scintillatus Doyen, 1988
Paratype: 1 [unknown sex]. MEXICO: Jalisco, El Tuito, 27/VIII/1986. Col. M. Sánchez. Conservation status: Complete, well-preserved.
description: Published as part of Pérez-Hernández, Cisteil Xinum, 2017, An annotated catalogue of the Coleoptera types deposited in the National Insect Collection (CNIN) of the National Autonomous University of Mexico, pp. 1-128 in Zootaxa 4288 (1) on page 114, DOI: 10.11646/zootaxa.4288.1.1, http://zenodo.org/record/1010410
title: Veränderungen der vitreoretinalen Grenzfläche der Partneraugen bei Patienten mit idiopathischem Makulaforamen
Creators: name: Schick, Tina
name: Schaub, F.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Veränderungen der vitreoretinalen Grenzfläche (VRGF) wie die epiretinale Gliose (EG), vitreomakuläre Tranktion (VMT) bis zum Makulaforamen (MF) stellen ein hohes Risiko für eine Visusminderung dar. Bei Patienten mit MF am ersten Auge ist die Einschätzung eines möglichen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 182. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte
title: Früherkennung und Verlaufskontrolle diabetischer Augenveränderungen – aktueller Stand und Perspektiven
Creators: name: Guthoff, Rainer
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Die Prävalenz der diabetischen Retinopathie liegt bei 35,4% weltweit. Demographisch bedingt wird sowohl weltweit, wie auch in Deutschland mit einem Anstieg der Prävalenz in der kommenden Dekade gerechnet. In den ersten beiden Jahrzehnten der Erkrankung entwickeln die meisten Patienten[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 182. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte
DEVELOPMENT AND APPLICATION OF AN IN VITRO PHARMACODYNAMIC MODEL FOR USE IN EXAMINING NOVEL DOSING STRATEGIES FOR AMOXICILLIN VS. BETA-LACTAMASE NEGATIVE AMPICILL1N RESISTANT HAEMOPIHLUS INFLUENZAE
Creators: name: Maland, Matthew C.
Publisher: name: Maryland Shared Open Access Repository
Year: 2006

description: An in vitro pharmacodynamic model was designed to investigate the pharmacokinetic/pharmacodynamic (PK/PD) relationships of pulsatile, continuous infusion and traditional divided dose regimens of amoxicillin versus two strains of beta- lactamase-negative ampicillin-resistant (BLNAR) Haemophilus influenzae. Initial PK/PD model validation studies were conducted using the well characterized beta-lactam drug/organism combination of cephalexin and Staphylococcus aureus. This model generally reports a direct relationship between bactericidal activity and percent time above the minimum inhibitory concentration (%T>MIC) during a 24 h dosing interval which is independent of drug concentration, as expected for a beta-lactam. However, the relationship between bactericidal activity and %T>MIC is dependent on flow rate in this PD model. Continuous infusion regimens of amoxicillin demonstrated significantly greater bactericidal effects, measured by the area between the antibiotic time-kill curve and untreated growth control curve (ABBC integral), as compared to traditional divided dosing or pulsatile regimens achieving equivalent or greater %T>MIC. Thus, continuous infusion dosing regimens of amoxicillin represent effective and novel dosing strategies for infections caused by BLNAR H. influenzae.
Micrasida obrienorum Smith 2013
Creators: name: Pérez-Hernández, Cisteil Xinum
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Tenebrionidae
Micrasida
Micrasida obrienorum

description: - Micrasida obrienorum Smith, 2013
Paratypes: 2 [unknown sex]. MEXICO: Nuevo León 3 mi. E Jcn. 57 & 60, 23/VI/1971. Colls. L. & C.W. O’Brien. Labeled: Tenebrionid base Aaron D. Smith Catalog # 78026, 0 7842. Conservation status: Complete, well-preserved.
description: Published as part of Pérez-Hernández, Cisteil Xinum, 2017, An annotated catalogue of the Coleoptera types deposited in the National Insect Collection (CNIN) of the National Autonomous University of Mexico, pp. 1-128 in Zootaxa 4288 (1) on page 114, DOI: 10.11646/zootaxa.4288.1.1, http://zenodo.org/record/1010410
Design, synthesis and biological evaluation of sulfamethazine derivatives as potent neuraminidase inhibitors
Creators: name: Cheng, Li Ping
name: Zhang, Xing Yong
name: Pang, Wan
name: Xiao, Xiu Zhen
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Hematology

description: Aim: The purpose of this study is to design and synthesize a new series of sulfamethazine derivatives as potent neuraminidase inhibitors. Materials & methods: A sulfamethazine lead compound, ZINC670537, was first identified by structure-based virtual screening technique, then some novel inhibitors X1–X10 based on ZINC670537 were designed and synthesized. Results: Compound X3 exerts the most good potency in inhibiting the wild-type H5N1 NA (IC50 = 6.74 μM) and the H274Y mutant NA (IC50 = 21.09 μM). 150-cavity occupation is very important in determining activities of these inhibitors. The sulfamethazine moiety also plays an important role. Conclusion: Compound X3 maybe regard as a good anti-influenza candidate to preform further study. A series of novel sulfamethazine neuraminidase inhibitors were designed and synthesized. A novel lead compound ZINC670537 was screened out by means of structure-based virtual screening, molecular dynamic simulation and bioactivity test. A series of novel sulfamethazine neuraminidase inhibitors were designed and synthesized. Compound X3 has the best inhibitory activity, and its activity inhibiting the H274Y mutant NA is comparable to that of OSC. Molecular docking studies have shown that the 150-cavity plays an important role in discovery of novel sulfamethazine NA inhibitors. The sulfamethazine moiety interacts tightly with three key residues (Arg118, Arg292, Arg371) by forming hydrogen bondings, which is beneficial to improve activity of compound. The results of this work provide new insights into the design of more potent NA inhibitors.
Expression of concern: dabigatran and other “target-specific oral anticoagulants"
Creators: name: Ramirez, Jorge H
Publisher: name: figshare
Year: 2014
Subjects: Medicine
Pharmacology

description: XVI Research Symposium at Valle University, Cali, Colombia. October 22-23 -- Definitive poster: pending ABSTRACT Introduction Dabigatran (Pradaxa, Boehringer Ingelheim) was the first approval of a novel class of drugs named “target-specific oral anticoagulants" because of a different mechanism of action to traditional oral anticoagulants (i.e., warfarin). Other drugs belonging to the same pharmacological class of dabigatran, but produced by different pharmaceutical companies (i.e., apixaban and rivaroxaban), were also approved by drug regulatory agencies around the world (EMA: Mar 2008 & FDA: Oct 2010). Pharmaceutical companies owners of patents on “target-specific oral anticoagulants" claimed that monitoring of coagulation was not required with these drugs. Shortly after the approval of these novel anticoagulants several concerns were about their safety were published by independent sources (e.g., Prescrire,Therapeutics Initiative, and responses to RE-LY dabigatran clinical trial in the NEJM). Recently, a series of articles were published by The BMJ (Jul 2014) discussing serious safety concerns with dabigatran due to cases of severe bleeding in patients medicated with this drug. Methods Analysis of dabigatran clinical trial registries ClinicalTrials.gov and EudraCT Results - Over 80% of dabigatran clinical trials remain unpublished - There are several concerns expressed by different sources about dabigatran key trial (RE-LY clinical trial which recruited over 18000 patients). Conclusions - Dabigatran data is being withheld by Boehringer. - FDA & EMA have regulatory roles with faculties to approve or deny the entry of drugs to the market, as well as their availability to prescribers and patients. However, the dabigatran story is also another example of how these agencies could act more as facilitators than regulators of active pharmacological principles.
title: Hat das Ausmaß des Papillenödems nach Zentralvenenverschluss Einfluss auf die Entwicklung eines Makulaödems?
Creators: name: Schröder, Katharina
name: Alder, J.
name: Geerling, G.
name: Guthoff, R.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Ein Zentralvenenverschlus (ZVV) kann durch die Ischämie, das sekundäre Makulaödem (MÖ) und die Folgen von sekundärer proliferativer Retinopathie zu permanentem Funktionsverlust führen. Das MÖ ist meist pharmakologisch behandelbar. Die Obstruktion der Zentralvene[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 182. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte
Microschatia planata Doyen & Brown in Brown & Doyen 1991
Creators: name: Pérez-Hernández, Cisteil Xinum
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Tenebrionidae
Microschatia
Microschatia planata

description: - Microschatia planata Doyen & Brown in Brown & Doyen, 1991
Paratypes: 2 [unknown sex]. MEXICO: Baja Cal. Norte Miller’s landing, 6/IV/1976, on sand dunes, at night, Doyen. Collection of Kirby W. Brown. Labeled: Tenebrionid base Aaron D. Smith Catalog # 78026, 0 4107. Conservation status: Complete, well-preserved.
description: Published as part of Pérez-Hernández, Cisteil Xinum, 2017, An annotated catalogue of the Coleoptera types deposited in the National Insect Collection (CNIN) of the National Autonomous University of Mexico, pp. 1-128 in Zootaxa 4288 (1) on page 114, DOI: 10.11646/zootaxa.4288.1.1, http://zenodo.org/record/1010410
State Bans on Affirmative Action and Talent Loss Among Blacks and Latinos in the United States
Creators: name: Lutz, Amy
name: Bennett, Pamela R.
name: Wang, Rebecca
Publisher: name: University of California Press
Year: 2020

description: Although affirmative action in college admissions is constitutionally permissible, several states prohibit it. We investigate whether bans push black and Latino students from in-state public selective colleges to other types of postsecondary institutions, thus contributing to talent loss among these groups. Unlike most other studies, we analyze national data (the High School Longitudinal Study of 2009) so that we can follow students across state lines. We find no evidence that students from ban states shift from one type of selective college to another; that is, from in-state public flagships to in-state private ones or selective colleges in other states. However, the odds of attending a nonselective college, instead of an in-state public selective college, are almost three times higher among blacks and Latinos in ban states compared with their counterparts in states without bans. We argue that bans on affirmative action may contribute to talent loss among black and Latino students.
title: Quel est l'impact des troubles d'apprentissage et des difficultés comportementales sur les caractéristiques motivationnelles des élèves au primaire ?
title: Quel est l'impact des troubles d'apprentissage et des difficultés comportementales sur les caractéristiques motivationnelles des élèves au primaire ?
titleType: AlternativeTitle
Creators: name: Andrey, Lionel
Publisher: name: Unknown
Year: 0
Subjects: subject: caractéristiques motivationnelles
subject: concept de soi
subject: attitude envers l’école
subject: difficultés de comportement
subject: troubles d’apprentissage

description: Chaque enfant, est singulier dans la manière qu’il a de percevoir et d’interpréter ce à quoi il est confronté dans son quotidien. Cette autoévaluation amène l’élève à se construire une représentation cognitive de ses propres caractéristiques. Il est possible d’évaluer et de quantifier, à l’aide de questionnaires, ce qu’on appelle ici les caractéristiques motivationnelles d’un élève. Celles-ci se déclinent en plusieurs concepts observables : le concept de soi (CS), la motivation et l’attitude envers l’école. Ces différentes dimensions sont soumises à plusieurs influences, dont les caractéristiques des élèves font partie. Parmi elles, cette recherche a pour objectif d’évaluer l’impact des troubles d’apprentissage et des difficultés de comportement sur les caractéristiques motivationnelles des élèves au primaire. Pour ce faire, un questionnaire (COSOI) a été soumis à l’effectif de deux classes de 5-6H dans le but de permettre aux élèves de s’évaluer au regard des différentes dimensions pertinentes : CS académique, CS mathématiques, CS social, attitude envers l’école et motivation. La sélection des élèves considérés comme ayant des troubles d’apprentissage a été basée sur les diagnostiques de ceux-ci. Les élèves ont été décrétés comme ayant des difficultés de comportement sur la base des fréquences des comportements perturbateurs ou agressifs de chaque élève, évaluées par l’enseignante. L’échantillon comprend 44 élèves. Au final, 27 élèves n’ont aucun trouble ou difficulté ; 11 n’ont pas de trouble d’apprentissage mais des difficultés comportementales ; 5 ont des troubles d’apprentissage sans difficulté de comportement ; 1 seul élève combine trouble d’apprentissage et difficulté de comportement. Les résultats montrent que la présence de difficultés de comportement ou de troubles d’apprentissage seuls ne semble pas lié à un concept de soi académique ou social diminué. Par contre l’attitude envers l’école (et le plaisir de venir à l’école) semble impactée négativement pour les deux catégories d’élèves. Enfin, la motivation perçue par l’enseignante est plus basse dans le groupe des élèves avec des troubles d’apprentissage. Les recherches sur ce thème n’étant pas nombreuses, celle-ci apporte donc un aperçu restreint mais pertinent de l’influence possible de troubles d’apprentissage ou de difficultés comportementales sur les caractéristiques motivationnelles des élèves en primaire.
Orthostibia frontalis Blaisdell 1923
Creators: name: Pérez-Hernández, Cisteil Xinum
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Tenebrionidae
Orthostibia
Orthostibia frontalis

description: - Orthostibia frontalis Blaisdell, 1923
Paratypes: 2 [unknown sex]. MEXICO: Baja California Sur, Espitiru Santo I., Gulf of California, 09/VI/1921. Col. J. C. Chamberlin; Ballena Isd. Labeled: “ Spec. No. 1064”.
Conservation status: Complete, well-preserved.
description: Published as part of Pérez-Hernández, Cisteil Xinum, 2017, An annotated catalogue of the Coleoptera types deposited in the National Insect Collection (CNIN) of the National Autonomous University of Mexico, pp. 1-128 in Zootaxa 4288 (1) on page 114, DOI: 10.11646/zootaxa.4288.1.1, http://zenodo.org/record/1010410
Establishment of embryogenic cultures in several cultivars of Vitis vinifera and V. x labruscana
Creators: name: Nakano, M.
name: Sakakibara, T.
name: Watanabe, Y.
name: Mıı, M.
Publisher: name: VITIS - Journal of Grapevine Research
Year: 2015

description: Establishment of embryoenic cultures was examined for different tissue explants in 23 cultivars of grapevine (Vitis spp.). The explants were initially cultured on callus induction media (C media) for 2 months; and those producing calli were then transferred to an embryogenesis induction medium (E medium) containing 1 µM 2,4-dichlorophenoxyacetic acid (2,4-D), on which adventitious embryos or embryogenic calli were induced 4 to 6 months after transfer. C media containing 10 µM 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) in combination with 10 µM N-(2-chloro-4-pyridyl)-N'-phenylurea (CPPU) or N-(1,2,3-thiadiazol-5-yl)-N'-phenylurea (TDZ) were suitable for inducing subsequent adventitious embryogenesis from leaf explants of V. vinifera Koshusanjaku. Adventitious embryogenesis was more efficiently induced from immature ovary explants than leaf and anther ones. Among 23 cultivars examined, embryogenic cultures, such as embryogenic calli or adventitious embryos proliferating via secondary embryogenesis, were established in 10 cultivars including V. vinifera Sekirei, Rosario Bianco, Semillon and Merlot, and V. x labruscana Delaware. These embryogenic cultures could be maintained without loosing a high regeneration capacity for over 20 months by subculturing onto fresh E medium. They could be useful as a target material for Agrobacterium- or particle gun-mediated genetic transformation.
description: VITIS - Journal of Grapevine Research, Vol. 36 No. 3 (1997): Vitis
Genomic organization and expression of an osmotin-like gene in Vitis vinifera L.
Creators: name: Loulakakis, K. A.
Publisher: name: VITIS - Journal of Grapevine Research
Year: 2015

description: Southern analysis of genomic DNA indicated the presence of a multigene osmotin-like family in the grapevine genome. The expression of one of these genes that corresponds to the previously isolated pVVOSM1 cDNA is developmentally regulated showing high transcript levels in root, stem and leaf tissues of in vitro-grown plants, intermediate in calluses and berries and low in cell suspensions. Treatment of cell suspension cultures with abscisic acid (ABA), ethylene or NaCl resulted in high levels of expression of the pVVOSM1 gene suggesting regulation of the osmotin-like gene by the abiotic signals mentioned above.
description: VITIS - Journal of Grapevine Research, Vol. 36 No. 3 (1997): Vitis
Isolation of 2-ethyl-3-methylmaleimide N-β-D-glucopyranoside from Riesling wine
Creators: name: Baderschneider, B.
name: Messerer, M.
name: Winterhalter, P.
Publisher: name: VITIS - Journal of Grapevine Research
Year: 2015

description: A glycosidic isolate of Riesling urine was separated with multilayer coil countercurrent chromatography (MLCCC). After acetylation and subsequent purification by high performance liquid chromatography (HPLC), the N-beta-D-glucopyranoside of 2-ethyl-3-methylmaleimide (3-ethyl-4-methyl-1H-pyrrole-2,5-dione) 2 was identified for the first time as natural wine constituent. The identification was carried out by mass spectrometry (EI-MS, DCI-MS) as well as nuclear magnetic resonance spectroscopy (H-1 NMR, 13C NMR, COSY, HMBC).
description: VITIS - Journal of Grapevine Research, Vol. 36 No. 3 (1997): Vitis
Reifying the Reflectogram Towards Explicit Control for Implicit Reflection
Creators: name: Papoulias, Nikolaos
Publisher: name: figshare
Year: 2015
Subjects: subject: 80309 Software Engineering
subject: FOS: Computer and information sciences
subject: Computer Software
subject: Applied Computer Science

description: Reflective facilities in OO languages are used both for implementing language extensions (such as AOP frameworks) and for supporting new programming tools and methodologies (such as object-centric debugging and message-based profiling). Yet controlling the run-time behavior of these reflective facilities introduces several challenges, such as computational overhead, the possibility of meta-recursion and an unclean separation of concerns between base and meta-level. In this paper we present five dimensions of meta-level control from related literature that try to remedy these problems. These dimensions are namely: temporal and spatial control, placement control, level control and identity control. We argue that the reification of the descriptive notion of the reflectogram, can unify the control of meta-level execution in all these five dimensions. We present a model for the reification of the reflectogram and validate our approach through a prototype implementation in the Pharo programming environment. Finally we detail a case-study on run-time tracing illustrating our approach.
Mercury: Properties and Design of a Remote Debugging Solution using Reflection
Creators: name: Papoulias, Nikolaos
Publisher: name: figshare
Year: 2015
Subjects: subject: 80309 Software Engineering
subject: FOS: Computer and information sciences
subject: Computer Software
subject: Applied Computer Science

description: Remote debugging facilities are a technical necessity for devices that have limited computing power to run an IDE (e.g., smartphones), lack appropriate input/output interfaces (display, keyboard, mouse) for programming (e.g mobile robots) or are simply unreachable for local development (e.g cloud-servers). Yet remote debugging solutions can prove awkward to use due to their distributed nature. Empirical studies show us that on average 10.5 minutes per coding hour (over five 40-hour work weeks per year) are spend for re-deploying applications while fixing bugs or improving functionality. Moreover current solutions lack facilities that would otherwise be available in a local setting because its difficult to reproduce them remotely. Our work identifies three desirable properties that an ideal solution for remote debugging should exhibit, namely: run-time evolution, semantic instrumentation and adaptable distribution. Given these properties we propose and validate Mercury, a live remote debugging model and architecture for reflective OO languages.
Otocerus chamelensis Doyen 1988
Creators: name: Pérez-Hernández, Cisteil Xinum
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Tenebrionidae
Otocerus
Otocerus chamelensis

description: - Otocerus chamelensis Doyen, 1988
Paratype: 1 [unknown sex]. MEXICO: Jalisco, Estación de Biología Chamela, UNAM, 07–15/VII/1987. Col. J. Chemsak, E. G. y J. M. Linsley, at light.
Conservation status: Complete, well-preserved.
description: Published as part of Pérez-Hernández, Cisteil Xinum, 2017, An annotated catalogue of the Coleoptera types deposited in the National Insect Collection (CNIN) of the National Autonomous University of Mexico, pp. 1-128 in Zootaxa 4288 (1) on page 114, DOI: 10.11646/zootaxa.4288.1.1, http://zenodo.org/record/1010410